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<projects><project>
<id>1321</id><title_hr><![CDATA[Metode slabih convergencija i primjene]]></title_hr><title_en><![CDATA[Weak convergence methods and applications]]></title_en><user_id>58</user_id><user_firstLast_name>Nenad Antonić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-9780</code><acronim><![CDATA[WeConMApp]]></acronim><duration>01.07.2014 - 30.06.2018</duration><status>Završio</status><financ_value>114.136,16 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>349, 72, 637, 866, 3374, 86, 1460, 628, 19188, 23449, </team_members_id><team_members_names><![CDATA[Krešimir Burazin, Marko Erceg, Ivan Ivec, Martin Lazar, Nedžad Limić, Marin Mišur, Darko Mitrovic, Marko Vrdoljak, Boris Pawilowski, Ivana Vojnović, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[weak convergences, partial differential equation, homogenisation, optimal design, H-measures, semiclassical measures, transport problems]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Weak convergences are the foundation of most successful methods in the investigation of partial differential equations today. The approach known as Tartar&#39;s programme proved particularly convenient for partial differential equations modelling physical laws; the basic assumption being that weak convergences of sequences of solutions model the transition from microscale to macroscale. Of importance are also mathematical objects being, in a generalised sense, accumulation points of weakly convergent sequences, such as defect measures or H-measures. The research will be directed towards improving the existing weak convergence methods, designing new mathematical objects for that purpose, as well as developing new methods, with particular attention paid to their applications to practical problems.Problems known as homogenisation are tied to properties of mixtures of materials, with important applications in optimal design. Problems related to evolutionary equations and their admissibility conditions mainly concern transport problems in free and porous media, where it is sometimes natural to include continuous time random walk variables in the model. Such problems sometimes also lead to fractional derivative equations. Some problems are related to hyperbolic conservation laws and the propagation and interaction of singularities. High-frequency waves corresponding to solutions of hyperbolic systems are governed by ODEs, allowing for final interpretation as particles. Particularly interesting are situations where the equation changes its type (like transonic fluid flow), motivating our interest in Friedrichs systems. Further results for semilinear systems could open a new approach to the Maxwell-Dirac system, with potential applications in quantum field theory. Practical computation of coefficients in specific applications is also important; as the unknown functions have the domain in multidimensional space, quite often more efficient numerical methods have to be developed.]]></summary_en></project><project>
<id>1326</id><title_hr><![CDATA[Konceptualiziranje nacije i kolektivnih identiteta u Hrvatskoj: Politički rituali i kulturalna memorija trauma 20. stoljeća]]></title_hr><title_en><![CDATA[Framing the Nation and Collective Identity in Croatia: Political Rituals and the Cultural Memory of Twentieth Century Traumas]]></title_en><user_id>2671</user_id><user_firstLast_name>Vjeran Pavlaković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-3782</code><acronim><![CDATA[FRAMNAT]]></acronim><duration>10.06.2014 - 09.06.2018</duration><status>Završio</status><financ_value>68.541,97 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Povijest, </scie_field_hr><scie_field_en>History, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Filozofski fakultet u Rijeci]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>6622, 4388, 7594, 17786, 7594, </team_members_id><team_members_names><![CDATA[DAVOR PAUKOVIĆ, Benedikt Perak, Tamara Banjeglav, Renato Stanković, Tamara Banjeglav, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Cultural memory, war, discourse analysis, collective identity, media]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Commemorations and other political rituals are key components of a nation’s cultural memory, crucial for the construction and reinforcement of ideological, ethnic, economic, gender, and other identities. FRAMNAT will involve a dynamic team of young scholars and develop innovative methodologies for cultural memory research and cognitive linguistics analysis relevant for Croatia’s academic and policy-making community, as well as a much broader transnational audience. Croatia’s commemorative culture regarding the wars of the 20th century serves as a platform for politicians to operate within the nation-building narratives. Our project will analyze both top-down and bottom-up strategies of framing the nation and collective identities through commemorative practices of World War Two and the Homeland War in Croatia.  These discourses will be analyzed at three levels: top-down political discourse (elites), media representation and transmission, and the reception of the narratives in Croatian society (bottom-up reactions). Seven commemorations related to World War 2 and the Homeland War will be observed and analyzed using corpus-based linguistic analysis and frame analysis. The media representations of the commemorative events and opinion poll data will likewise be analyzed in order to map how these discourses are transmitted and received in Croatian society. The project results will be disseminated via a regularly updated website (which includes a database of the collected research materials), journal articles, an edited volume, and papers presented at international conferences. Students and other members of the scholarly community will be encouraged to participate in the project through a variety of workshops to be held at the University of Rijeka. The long-term goal is to develop a Cultural Memory Research Center with scientific methods which can be applied to other regional and international case studies.    ]]></summary_en></project><project>
<id>1327</id><title_hr><![CDATA[Pravni aspekti korporativnih akvizicija i restrukturiranje trgovačkih društava utemeljeno na znanju ]]></title_hr><title_en><![CDATA[Legal Aspects of Corporate Acquisitions and Knowledge Driven Companies&#39; Restructuring]]></title_en><user_id>345</user_id><user_firstLast_name>Edita Čulinović-Herc</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-9366</code><acronim><![CDATA[LACAKDCR]]></acronim><duration>01.02.2015 - 31.01.2019</duration><status>Završio</status><financ_value>78.145,60 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Pravo, </scie_field_hr><scie_field_en>Law, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Pravni fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Law]]></institution_en><team_members_id>3403, 3741, 618, 2793, 3020, 3047, 2685, 626, 4067, </team_members_id><team_members_names><![CDATA[Nataša Žunić Kovačević, Dionis Jurić, Ivana Kunda, Vlatka Butorac Malnar, Antonija Zubović, Mihaela Braut Filipović, Stjepan Gadžo, Danijela Vrbljanac, Nikolina Grković, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[corporate acquisitions, mergers, takeovers, concentrations, taxation of corporate acquisitions,  knowledge based restructuring ]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[In the EU post-accession era, Croatian companies are facing the challenges of corporate acquisitions and restructurings. The latter is an inevitable result of new EU competitors entering the Croatian market. Cross-border and/or domestic corporate regrouping may take different forms depending on the chosen legal model. While being multi-layered phenomena, corporate acquisitions and restructurings are covered by several specialized legal disciplines which the contemporary legal doctrine does not observe as a whole. The aim of this research is to combine the various legal aspects of corporate acquisitions focusing on knowledge driven companies’ restructuring as the most beneficial model. Accordingly, the proposed research will analyze legal models of corporate acquisitions, financing techniques, taxation issues, intellectual property and related competition law concerns, covering thus the topic from the point of company law, capital market law, tax law, competition law and intellectual property law. The research will combine the legislative, judicial and theoretical analysis with the relevant empirical analysis. Cross-referenced results in the respective fields and their systemization will enable the creation of scientifically founded and empirically tested legislative proposals in one single-package. The aim is to enhance the level of protection of all interested parties of corporate acquisitions and knowledge driven restructurings either via strengthening ex ante and/ or ex post control. The results will be disseminated to the legislator, regulators, judiciary and companies as ultimate beneficiaries. What more, project results will enable companies to optimize their choices of restructuring and their position on the market. The dissemination of the project results will ultimately promote and develop knowledge driven restructuring that should in turn increase the competitiveness of the Croatian companies and stimulate the overall economic growth. ]]></summary_en></project><project>
<id>1329</id><title_hr><![CDATA[Fizika Standardnog modela i njena proširenja]]></title_hr><title_en><![CDATA[Physics of the Standard Model and Beyond]]></title_en><user_id>2665</user_id><user_firstLast_name>Blazenka Melic</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-5169</code><acronim><![CDATA[PhySMaB]]></acronim><duration>01.10.2014 - 30.09.2018</duration><status>Završio</status><financ_value>96.064,69 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>5180, 4709, 5888, 17814, 21412, </team_members_id><team_members_names><![CDATA[Goran Duplančić, Fabrizio Nesti, Kornelija Passek-Kumerički, Goran Popara, Domagoj Leljak, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[theoretical particle physics,  Standard Model, perturbative calculations, physics beyond Standard Model, neutrinos]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[In high energy particle physics it is widely believed that the energy frontier experiments at LHC and the planned linear colliders, ILC and/or CLIC, together with ongoing and new experiments in neutrino and flavour physics will unravel fundamental problems in particle and astroparticle physics. A prerequisite for this progress is the complete understanding of the Standard model (SM) predictions. One of the triumphs of SM physics has been the extent to which QCD successfully describes strong interaction processes observed at colliders. More accurate QCD calculations are nowadays essential in understanding the enormous amount of available high-precision data, particularly since new physics effects are obscured by standard QCD processes. Our focus in that area will be to improve the description of hard exclusive processes by including higher-order contributions and by further developing the corresponding methods for automatic QCD calculations. Furthermore, we plan to do precision studies of top-quark production and decay observables which provide a unique view to the mechanism of electroweak symmetry breaking, important for understanding of particle mass generation. In the top-quark decay the information about its spin polarization imprinted by the production process is preserved, and can be calculated and measured in angular distributions of decay products providing other way to search for deviations from the SM expectations. Regarding new physics, the fact that neutrinos have a mass already requires an extension of the SM and calls for an understanding of the origin of neutrino masses. The seesaw mechanism, included in a theory as the one where left-right symmetry (parity) is restored at accessible LHC energies, stands out as a prominent theoretical candidate, and this theory links the origin of neutrino masses to new interactions at high energies and to the restoration of parity. A phenomenological investigation of these predictions is thus compelling and timely.]]></summary_en></project><project>
<id>1338</id><title_hr><![CDATA[Uloga signalnog puta Wnt u epitelno-mezenhimskoj tranziciji]]></title_hr><title_en><![CDATA[The Role of Wnt signaling in Epithelial to Mesenchymal Transition]]></title_en><user_id>139</user_id><user_firstLast_name>Nives Pećina-Šlaus</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-6625</code><acronim><![CDATA[WNT4EMT]]></acronim><duration>01.09.2014 - 31.08.2018</duration><status>Završio</status><financ_value>106.178,25 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>2813, 1169, 2587, 441, 354, 445, 1170, 3553, 4751, 4287, 4859, 19002, </team_members_id><team_members_names><![CDATA[Davor Tomas, Tomislav Vladušić, Hrvoje Ivan Pećina, Tamara Nikuševa Martić, Anja Kafka, Ljiljana  Šerman, Reno Hrašćan, vili beroš, Martina Zeljko, Goran Mrak, Denys Neville  WHEATLEY, Anja Bukovac, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Wnt signaling, EMT, brain tumors, invasion, dishevelled, TCF/LEF]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[In the proposed research project we aim to determine the involvement of Dishevelled and TCF/LEF families of human genes in the process of Epithelial-to-Mesenchymal Transition (EMT) in brain tumors. We believe that the changes of structure and expression of the selected genes correlate with the phenotypic changes of tumor cells. EMT is a process very much involved in invasion and progression of tumors. Many oncogenic signaling pathways can induce EMT. The classical Wnt pathway has a particularly tight link with EMT and it has been shown that nuclear translocation of beta-catenin can induce EMT. Wnt pathway is one of the basic cellular pathways whose misregulation plays important roles in tumorigenesis and whose mediators of transcription are members of TCF/LEF family. Another important protein family is the Dishevelled considered to be the central hub of Wnt signaling since it interacts with Wnt receptors and recruits the multiprotein beta-catenin destruction complex. The experiments of the proposed research will use modern methods of molecular biology for the analyses of brain tumor samples of different malignancy grades. The genetic changes will be tracked by PCR/loss of heterozygosity, heteroduplex and Spreadex electorphoresis (Elchrom Scientific, Switzerland) methods. Expression of selected proteins will be studied by immunohistochemistry demonstrating their location in tumor cells. Besides its scientific value, results from the proposed project will have an application in medical diagnostics. Identifying changes in molecules responsible for control of cell motility will give us the preconditions for understanding the invasiveness of brain tumors and offer new disease progression markers. Our experimental evidence would also encourage the development of therapies that specifically interfere with Wnt signaling in cancer. ]]></summary_en></project><project>
<id>1340</id><title_hr><![CDATA[Algebarske i kombinatorne metode u teoriji verteks algebri]]></title_hr><title_en><![CDATA[Algebraic and combinatorial methods in vertex algebra theory]]></title_en><user_id>92</user_id><user_firstLast_name>Dražen Adamović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-2634</code><acronim><![CDATA[ACMVAT]]></acronim><duration>01.07.2014 - 30.06.2018</duration><status>Završio</status><financ_value>70.677,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>1285, 1098, 746, 1252, 631, 636, 632, 687, 1138, 638, 4027, 17775, </team_members_id><team_members_names><![CDATA[Goran Trupčević, Marijan Polić, Josip Vujčić, Tomislav Šikić, Gordan Radobolja, Slaven Kožić, Ozren Perše, Marijana Butorac, Miroslav Jerković, Mirko Primc, Boris Širola, Ana Kontrec, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[vertex algebras, W-algebras,  affine  Lie algebras, logarithmic  CFT, combinatorial bases,  Zhu&#39;s algebras, C2 cofiniteness,]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[In the proposed project we shall study the representation theory of important classes of vertex algebras with particular emphasis on the theory of vertex algebras with origins  in physics. We shall also study the affine vertex algebras and their connections with W-algebras. Based on previous research of D. Adamović and O. Perše from the papers J. Algebra 319 (2008); SIGMA 8 (2012); Algebras and Representation Theory 16 (2013) we shall apply the representation theory of vertex algebras of affine type   to the structure and representation theory of W-algebras. In the last few years, C2-cofinite, irrational vertex algebras with non-semisimple representation categories attracted a lot of interest. Such vertex algebras also appear in the logarithmic conformal field theory. By using methods developed in the papers by  D. Adamović and  A. Milas: Adv. Math. 217 (2008), Comm. Math. Phys. 288 (2009),  Adv. Math. 227 (2011)  and  J. Math. Phys. 73511 (2012) we shall study the representation theory of certain irrational, C2-cofinite vertex algebras and their connections with the theory of quantum groups. An emphasis will be put on the tensor categories of modules of C2-cofinite vertex algebras, the determination of fusion rules, orbifold vertex subalgebras and the explicit realization of logarithmic representations.  A part of the research will be devoted to some combinatorial aspects of the  representation theory of affine Kac-Moody Lie algebras. We will study  the application of intertwining operators   on the determination of   combinatorial bases of Feigin-Stoyanovsky type subspace and the associated fermionic character formulas developed by M. Primc and  collaborators. We also plan to apply the above methods on the combinatorial structures related to triplet vertex algebras and logarithmic CFT.]]></summary_en></project><project>
<id>1341</id><title_hr><![CDATA[Otvaranje obrazovanja kroz učenje unutar i izvan škola i kolaboraciju na mobilnim tablet računalima]]></title_hr><title_en><![CDATA[Opening up education through Seamless and COLLAborative Mobile learning on tablet computers]]></title_en><user_id>151</user_id><user_firstLast_name>Ivica Botički</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2013-11</proposal_call><code>UIP-2013-11-7908</code><acronim><![CDATA[SCOLLAm]]></acronim><duration>01.09.2014 - 31.08.2017</duration><status>Završio</status><financ_value>102.115,27 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>2986, 2994, 3154, 3186, 6008, 3612, </team_members_id><team_members_names><![CDATA[Neven Drljevic, Vedran Mornar, Igor Mekterovic, Natasa Hoic-Bozic, Peter Seow, Tomislav Jagušt, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[seamless learning, mobile learning, technology enhanced learning, collaborative learning, informal learning, educational technology]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[This project explores the potential of using mobile technology for seamless and mobile learning in Croatia and proposes a technologically innovative mobile learning platform named SCOLLAm. Being one of the first scientific mobile learning projects in Croatian schools, it explores both technology and pedagogies through two studies leveraging tablet computers in Croatian classrooms. In the first study, SCOLLAm will be deployed in a primary school to support new seamless and collaborative lessons in and across the existing subjects. In the second study, augmented mobile learning technology and the accompanying digital lessons will be used as a tool to support seamless and collaborative learning in a vocational school. These studies seek to stimulate and explore the effectiveness of mobile learning in Croatian schools in a strictly scientific manner, by engaging in digital mobile lesson co-design with the school teachers. The project will leverage experience from mobile learning research groups from Singapore, Sweden and USA in order to develop a new set of tools and lessons suitable for Croatian educational system. In order to move away from the tools typically targeting one platform and providing only limited adaptation mechanisms with virtually no learning analytics, one of the project objectives is the design, development and deployment of a scalable, adaptive and analytics driven platform SCOLLAm. Through the designed studies, produced open localizable educational resources and the SCOLLAm platform, we expect to see that the participants benefit from the introduction and use of mobile technology and applications through increased learning, collaboration skills and self-directedness, and acquire 21st century skills needed in their further education and life.]]></summary_en></project><project>
<id>1350</id><title_hr><![CDATA[Uvjeti, resursi, neprijatelji i bioraznolikost: Sile koje oblikuju morske zajednice u plitkom Jadranskom moru]]></title_hr><title_en><![CDATA[Conditions, Resources, Enemies, and Biodiversity: Forces structuring marine communities of the shallow Adriatic Sea]]></title_en><user_id>1269</user_id><user_firstLast_name>Stewart Schultz</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-3107</code><acronim><![CDATA[COREBIO]]></acronim><duration>01.10.2014 - 30.09.2018</duration><status>Prekinut</status><financ_value>97.694,66 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zadru]]></institution_hr><institution_en><![CDATA[University of Zadar]]></institution_en><team_members_id>3702, 5004, 4486, 6648, 17825, </team_members_id><team_members_names><![CDATA[Tatjana Bakran-Petricioli, Claudia Kruschel, Donat Petricioli, Alen Soldo, Dubravko Pejdo, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[community ecology, fish, Posidonia, habitat, monitoring]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[This project is an investigation of the major drivers of fish community structure in the shallow Adriatic Sea of Croatia.  This information is crucial for the sustainable, scientific management of coastal ecosystems, as required by EU instruments such as the Habitats Directive, Marine Strategy Framework Directive, Water Framework Directive, and the Common Fisheries Policy.   The major questions asked are 1) What are the ecological baselines in Croatia in community structure?  2) How does anthropogenic activity (harvesting, coastal development) shift community structure from baseline?  3) How do marine protected areas maintain functional communities?  4) How is community structure changing over time?   We will investigate these questions using innovative, non-destructive techniques for quantifying fish abundance and size distribution, and benthic habitat quality.  These techniques include lure-assisted, underwater visual census which was originally developed in the Schultz laboratory; baited, underwater video; and DGPS-assisted, towed underwater video.  EU policies require that non-destructive methods for assessment and monitoring replace destructive harvest-based methods currently in widespread use, and these methods are among the most scientifically supported non-destructive methods currently available.  These methods will be used to quantify fish community structure and benthic habitat at all major MPAs and former MPAs in Croatia, to compare communities within MPAs to matched locations outside MPAs.   Matched locations will be chosen to test for specific anthropogenic drivers of community structure, such as high fishing pressure, coastal development, marine tourism, aquaculture, and terrestrial runoff.  These results will advance our basic understanding of coastal ecosystems, and will be crucial for satisfying Croatia&#39;s responsibilities as an EU citizen in MPA construction, management, and monitoring of marine resources.]]></summary_en></project><project>
<id>1352</id><title_hr><![CDATA[Hrvatska u 20. stoljeću: modernizacija u uvjetima pluralizma i monizma]]></title_hr><title_en><![CDATA[Croatia in the 20th century: modernization in the context of pluralism and monism]]></title_en><user_id>515</user_id><user_firstLast_name>Zdenko Radelić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-3481</code><acronim><![CDATA[Croatia20thcentury]]></acronim><duration>01.07.2014 - 30.06.2018</duration><status>Završio</status><financ_value>27.367,44 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Povijest, </scie_field_hr><scie_field_en>History, </scie_field_en><institution_hr><![CDATA[Hrvatski institut za povijest]]></institution_hr><institution_en><![CDATA[Croatian Institute of History]]></institution_en><team_members_id>1344, 1060, 1350, 1375, 1361, 2545, 1357, 1345, 286, 2834, 2933, </team_members_id><team_members_names><![CDATA[Miroslav Akmadža, Nikica Barić, Davor  Kovačić, Zdravka Jelaska Marijan, Hrvoje Čapo, Josip Kajinić, Josip Mihaljević, Ivana Šubic Kovačević, Marko Zubak, Stipe Kljajić, Mario Jareb, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Croatia, Kingdom of Yugoslavia, Independent State of Croatia, Socialist Federative Republic of Yugoslavia, democracy, dictatorship, totalitarianism]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The aim of the project is to research the political, economical, social and cultural developments in Croatia from 1918 when Austro-Hungarian Empire collapsed, to 1991 when socialist Yugoslavia disintegrated. Thus the project covers the period of about 70 years, from 1914/1918 to 1991. The project will cover complete present day Croatian territory as well as neighbouring areas where necessary. The project will include various topic – ideologies and politics, national and religious questions, as well as culture, especially the role of media and sport in the social life. Research will cover a wide range of events and historical processes: formation and spreading of national and political ideas and their realization through the activities of political parties and movements; organization of state security and police; reconstruction of everyday life; the question of identity of various groups of Croatian society. The project will also cover the biographies of certain persons and how certain regimes treated them. More specifically the project will research the consequences of World War I on the population; the activities of state authorities of Kingdom of Serbs, Croats and Slovenes/Yugoslavia, Independent State of Croatia, Federal People&#39;s Republic of Yugoslavia/Socialist Federative Republic of Yugoslavia and to the present day Republic of Croatia. The research will concentrate on the question of freedom of nations and individuals and the influence of external political forces.]]></summary_en></project><project>
<id>1358</id><title_hr><![CDATA[Računalna rješenja u bioznanostima: Značaj savitljivosti molekula]]></title_hr><title_en><![CDATA[Computational Solutions in the Life Sciences: The Importance of Molecular Flexibility]]></title_en><user_id>326</user_id><user_firstLast_name>David Smith</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-8238</code><acronim><![CDATA[CompSoLS-MolFlex]]></acronim><duration>15.07.2014 - 14.12.2018</duration><status>Završio</status><financ_value>119.450,53 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>2848, 854, 56, 3235, 2682, 3093, 2666, 2736, 3618, 5501, 18936, </team_members_id><team_members_names><![CDATA[Nadja Doslic, Darko Babić, Borislav Kovačević, Danijela  Barić, Ana-Sunčana Smith, Karmen Čondić-Jurkić, Momir Mališ, Jurica Novak, Zlatko Brkljača, Ivan DRAGIČEVIĆ, Marko Hanževački, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Molecular Flexibility, Computational Chemistry, Peptides, Proteins, Enzyme Catalysis]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Molecular flexibility controls a number of key processes ranging from protein folding to the design of advanced materials. However, the detailed understanding of its impact on a given process is poorly understood. Direct investigation of this phenomenon by experimental means, is a challenging endeavour, as the microscopic details are frequently hidden from macroscopic observations. Computational simulations, on the other hand, provide detailed information regarding molecular dynamics and flexibility. The theoretical approach is thus crucial in both understanding the experimental results and in expanding the underlying conceptual framework.The present project proposes to utilize state-of-the-art computational techniques to address the importance of molecular flexibility across a range of carefully selected examples from the life sciences. The examples, which can be classified under the headings: (i) peptides and spectroscopy, (ii) protein flexibility, and (iii) enzyme related transformations, have been chosen to span multiple time and length scales and thus to highlight the diverse and wide-reaching nature of molecular flexibility. The selected examples exhibit a significant degree complementarity and synergy with one another and are all associated with their own applicative importance in different areas of (bio)chemistry.In addition to the scientific research proposed, the project aims to consolidate a highly successful and competitive platform in computational life sciences that has been established at the RBI. This platform was already recognized through the granting of an EU-FP6 project (2007-2010). The current project team is thus well equipped for the proposed work and exhibits a good balance between senior researchers, with excellent track records, and junior scientists with outstanding potential. The support of the project team by HrZZ is crucial for maintaining their competitiveness in the international scientific environment of computational life sciences.]]></summary_en></project><project>
<id>1366</id><title_hr><![CDATA[SINTEZA I CITOSTATSKA ISPITIVANJA  BIBLIOTEKE NOVIH DUŠIKOVIH HETEROCIKLA]]></title_hr><title_en><![CDATA[SYNTHESIS AND CYTOSTATIC EVALUATIONS OF NOVEL NITROGEN HETEROCYCLES LIBRARY]]></title_en><user_id>76</user_id><user_firstLast_name>Silvana Raić-Malić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-5596</code><acronim><![CDATA[SCIENcENTRY]]></acronim><duration>02.06.2014 - 31.05.2018</duration><status>Završio</status><financ_value>123.967,88 eur</financ_value><scie_area_hr>Prirodne znanosti, Biomedicina i zdravstvo, </scie_area_hr><scie_area_en>Natural sciences, Biomedicine and health sciences, </scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet kemijskog inženjerstva i tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Chemical Engineering and Technology]]></institution_en><team_members_id>3924, 2914, 2865, 2847, 2768, 2769, 1135, 3913, 1219, 2835, 2767, 3261, 2811, 17839, </team_members_id><team_members_names><![CDATA[Tatjana Gazivoda Kraljević, Marijana Hranjec, Livio Racané, Irena Sović, Maja Aleksić, Nataša Perin, Andrijana Meščić, Silvija Maračić, Maja Stipković Babić, Višnja Stepanić, Krešimir Pavelić, Mirela Sedić, Grace Karminski-Zamola, Andrea Bistrović, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[1,2,3-triazole-heterocycles hybrids, benzimidazoles, benzothiazoles, synthesis, cytostatic activity, in silico and docking analysis, DNA binding]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Cancer is one of the most serious health problems of a worldwide dimension. One in three of the population develops cancer at some time in their lives and one in four dies from this disease. The main problems in antitumor chemotherapy are drug resistance and side effects on normal tissues. In the recent years a tremendous growth was witnessed in synthesis and development of vast number and types of new heterocyclic antitumor agents, with an emphasis on creation of new drugs with better selectivity or activity. The latter are indeed major requirements in development of novel anticancer drugs. The proposed scientific project is highly interdisciplinary and objective-oriented with the principal aim to develop the novel lead compounds with pronounced and selective anticancer activity that would be used for further phases of drug development.To achieve the principal aim following specific tasks are foreseen. The goal of the first one is to synthesize small-compound library (Classes A–H) comprising new conjugates of pseudopurines, coumarines and quinolines with 1,2,3-triazole scaffold, N-acyclic 5-unsaturated pyrimidine derivatives, amino-, amido- and amidino substituted benzimidazole, benzothiazole and benzo[b]thieno-2-carboxamide derivatives. Molecule library will be synthesized using modern synthetic approaches such as click chemistry, palladium mediated cross-coupling, eco-friendly microwave assisted and photochemical reactions as well as classical organic synthetic methods. The aim of the second task is to predict plausible biological targets and pharmacological activities using cheminformatics/in silico analysis. The third task is to perform cytostatic evaluations based on which hit molecules with desired biological effect will be selected for structure optimization that will be subsequently carried out. Finally, the molecular mechanism studies are anticipated for the most effective compounds from synthesized N-heterocycles library.]]></summary_en></project><project>
<id>1367</id><title_hr><![CDATA[Periodički npregnuti grfen; strukturna i elektroska svojstva]]></title_hr><title_en><![CDATA[Periodically strained graphene; structural and electronic properties]]></title_en><user_id>105</user_id><user_firstLast_name>Petar Pervan</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-2727</code><acronim><![CDATA[PerStaGra]]></acronim><duration>01.07.2014 - 31.08.2016</duration><status>Prekinut</status><financ_value>46.851,15 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut za fiziku]]></institution_hr><institution_en><![CDATA[Institute of Physics in Zagreb]]></institution_en><team_members_id>3486, 3090, 3104, 6373, 6283, </team_members_id><team_members_names><![CDATA[Vesna Mikšić Trontl, Iva Šrut Rakić, Ivo Pletikosić , Tonica Valla, Asensio Maria Carmen, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[graphene, strain, vicinal surface, fermi velocity, spin-orbit coupling, STM, ARPES]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[A strained graphene offers a valuable avenue for the manipulation in altering its electronic structure. Graphene can withstand rather large elastic deformation and it appears that within the elastic response there is a range of different modifications in graphene’s electronic structure. This is a basis of what is called “strain engineering”. Recent theoretical calculations suggest that uniaxial strain or shear deformations can induce opening of the electron band gap, anisotropic modification of the Fermi velocity, spin-orbit interaction  and consequently alter the transport properties. However, there is still no consensus on the mechanical conditions required to obtain a particular electronic modification. In this project we propose a systematic study of structural and electronic properties of periodically rippled graphene. We have already demonstrated that graphene conforms to the stepped (vicinal) iridium surface – Ir(332) creating periodic structure at nanometer scale. It is aim of this project to experimentally explore the dependence of the electronic structure of graphene with respect to periodicity of the graphene corrugation, orientation of the graphene with respect to the shear deformation (zig-zag with respect to armchair direction). By intercalation of different elements we will alter the graphene substrate interaction with the aim to control the structure of the underlying surface and consequently valence band structure of graphene. We shall investigate structural properties of graphene on Ir(332) by Scanning Tunneling Microscope (STM) and Atomic Force Microscope (AFM). The focus in the investigation of electronic properties will be on the ARPES study of anisotropic distortion of the Dirac cone, relation with the direction of the graphene modulation, spin-orbit interaction and on the possibility to induce electron band gap. ]]></summary_en></project><project>
<id>1371</id><title_hr><![CDATA[Procjena i predviđanje produktivnosti šumskog ekosustava objedinjavanjem terenskih izmjera, daljinskih istraživanja i modeliranja]]></title_hr><title_en><![CDATA[Estimating and Forecasting Forest Ecosystem Productivity by Integrating Field Measurements, Remote Sensing and Modelling]]></title_en><user_id>360</user_id><user_firstLast_name>Hrvoje Marjanović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2013-11</proposal_call><code>UIP-2013-11-2492</code><acronim><![CDATA[EFFEctivity]]></acronim><duration>01.07.2014 - 30.06.2017</duration><status>Završio</status><financ_value>80.084,94 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Šumarstvo, </scie_field_hr><scie_field_en>Forestry, </scie_field_en><institution_hr><![CDATA[Hrvatski šumarski institut]]></institution_hr><institution_en><![CDATA[Croatian Forest Research Institute]]></institution_en><team_members_id>819, 1275, 843, 6352, 7033, 18937, 17816, </team_members_id><team_members_names><![CDATA[Maša Zorana Ostrogović, Ivan  Balenović, Elvis Paladinić, Krunoslav Indir, Zoltan Barcza, Anikó Kern, Mislav Anić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[forest productivity, Quercus robur, GPP, NPP, eddy covariance, MODIS, Biome-BGC, photogrammetry, dendrometers, soil respiration]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Forest play important role in climate regulation and secure resources vital for local economy,  but the imminent climate change will affect their productivity, and for some tree species possibly even their sustainability. Thus, monitoring forest productivity and understanding effects of key environmental drivers becomes essential for forest management. This is a challenging task, particularly due to great costs related to it. Hereby we propose a research, aimed at addressing this issue, with a novel approach that could facilitate fast and cost-effective assessments of forest productivity. The research would be conducted on pedunculate oak forests (Quercus robur L.) which are economically, and ecologically, one of the most important in Croatia.  Main objective of the proposed research is to develop and test methods and workflows for the estimation of annual productivity of forests at the local scale by using existing research infrastructure for measurement of carbon fluxes (EC monitoring system), freely available high temporal resolution data from remote sensing (MODIS) and state of the art process model (Biome-BGC). The proposed research will provide the first evaluation on the quality of MODIS GPP and NPP estimates for Central-European lowland forests. Field measurement campaigns combined with state of the art digital photogrammetry will be performed to parameterise Biome-BGC model, and validate data from MODIS and model simulations. Using available data on future climate scenarion, productivity of oak forests for the future 30-50 years will be simulated with Biome-BGC model.   The proposed research is in line with the objectives of the EU Forest Action Plan which, among others proposes to encourage adaptation to the effects of climate change (key action 6), and to work toward a European Forest Monitoring System (key action 8).]]></summary_en></project><project>
<id>1381</id><title_hr><![CDATA[PRIMJENA PLAZME STVORENE VISOKONAPONSKIM ELEKTRIČNIM PRAŽNJENJEM  PRI KONZERVIRANJU TEKUĆE HRANE ]]></title_hr><title_en><![CDATA[APPLICATION OF ELECTRICAL DISCHARGE PLASMA FOR PRESERVATION OF LIQUID FOODS]]></title_en><user_id>206</user_id><user_firstLast_name>Zoran Herceg</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-6248</code><acronim><![CDATA[NTP01]]></acronim><duration>15.09.2014 - 14.09.2018</duration><status>Završio</status><financ_value>112.814,39 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Prehrambena tehnologija, </scie_field_hr><scie_field_en>Food technology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Food Technology and Biotechnology]]></institution_en><team_members_id>526, 1307, 453, 448, 707, 493, 591, 590, 1002, 2653, 3170, 2917, 2609, 4033, </team_members_id><team_members_names><![CDATA[Selma Mededovic Thagard, Damir Stanzer, Jasna Mrvčić, Suzana Rimac Brnčić, Hrvoje Juretić, Tomislava  Vukušić, Marija  Badanjak Sabolović, Višnja Stulić, Ivona Elez Garofulić, Stela Križanović, Mara Banović, Ivančica Delaš, Zlatko Kregar, Vlasta Horvatić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Electrical discharge plasma, liquid-phase plasma reactor, liquid food, physico-chemical properties, nutritional and sensory properties]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[With the growing knowledge of the importance of food in maintaining the human health, the food industry is faced with increasing challenges to develop new non-thermal food treatment technologies that would prevent and mitigate food contamination while retaining nutritional and functional properties of the treated food. Electrical discharge plasma is one of these more promising techniques. Plasmas formed directly in liquid inactivate microorganisms and without significant increase in temperature during the treatment. However, knowledge gaps regarding the nature of sterilization, inactivation mechanism and the plasma reactor design have been identified as major constraints for the applicability of this technology in food industry. Thus the main goal of the proposed project is to design and develop a non-thermal plasma reactor for the treatment of fruit juices and milk and optimize it to maximize the utilization of UV light and chemical species produced by plasma.  To achieve this goal, we propose to address the following research objectives (R):R1     Develop and optimize a liquid-phase plasma reactor for treatment of fruit juices and milk.R2       Characterize the chemical and electrical properties of the liquid plasmas. R3  Evaluate the ability of the liquid-phase plasma to inactivate pathogenic microorganisms in suspensions of pure culture microorganisms and suspended in fruit juices and milk respectively. R4       Determine inactivation mechanism of the plasma treatments on microorganisms R5      Determine the effect of the plasma treatments on the physico-chemical, nutritional and sensory properties of juices and milk.The significance of the proposed research lies in the development of a novel plasma reactor as well as acquires new knowledge regarding the science behind the forthcoming plasma technology which can then be applied towards introducing and potentially replacing current processing technologies with plasma.]]></summary_en></project><project>
<id>1382</id><title_hr><![CDATA[Uloga receptora autofagije u selektivnom uklanjanju mitohondrija]]></title_hr><title_en><![CDATA[The role of autophagy receptors in selective removal of mitochondria]]></title_en><user_id>62</user_id><user_firstLast_name>Ivana Novak Nakir</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2013-11</proposal_call><code>UIP-2013-11-5246</code><acronim><![CDATA[AutoMito]]></acronim><duration>01.03.2015 - 30.09.2018</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Split School of Medicine]]></institution_en><team_members_id>3657, 6096, 17855, </team_members_id><team_members_names><![CDATA[Brady Nathan, Ivan Đikić, Mija Marinković, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[autophagy, mitochondria, mitophagy, receptor, neurodegeneration, cancer]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Autophagy is cellular degradation pathway essential for cell survival, development and differentiation. Its digestive property has been shown important in different pathologies including cancer, neurodegeneration and pathogen removal. Discoveries of specific autophagy receptors have opened a new chapter in the autophagy field. Of great interest is the removal of damaged or excess mitochondria through specialized autophagy- mitophagy. Together with colleagues, I have identified and characterized mitochondrial proteins Nix/Bnip3L and Bnip3 as a mitophagy receptors for recruiting the autophagic machinery to damaged mitochondria and help their elimination (Novak et al, 2010; Zhu et al, 2013). We demonstrated that receptors mediate mitochondrial clearance during reticulocyte differentiation. Our goal is to further study autophagy receptors and proteins associated with mitochondrial clearance to better understand the role of mitophagy and its mechanism. We will study: (1) phosphorylation and dimerization of receptors and the consequences of this events on mitophagy progression; (2)factors that regulate tight connection of apoptosis and mitophagy; (3)potential interplay between mitophagy receptors and other mitophagy-related proteins, like  E3-ligase Parkin and kinase PINK1; (4)the effects of mitophagy on cancer development. To reach our goals we will use established methodology in our laboratories including protein identification and interaction techniques (Western blot, IP, GST-pull down, RNAi), immunofluorescent microscopy, mass spectrometry, ITC and NMR. All experiments will be performed using cultured cells. This project proposal has a high capacity to generate very interesting data with high possibility for publications in top scientific journals. Fundamentally, generated data will help to understand the physiological and pathological conditions, such as neurodegeneration and cancer and allow us to manipulate mitophagy to fight diseases.]]></summary_en></project><project>
<id>1386</id><title_hr><![CDATA[Notch u diferencijaciji hematopoetskih stanica matica i u razvoju leukemija]]></title_hr><title_en><![CDATA[Notch in hematopoietic stem cell differentiation and leukaemia development ]]></title_en><user_id>498</user_id><user_firstLast_name>Mariastefania Antica</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-7140</code><acronim><![CDATA[NOBLE]]></acronim><duration>10.09.2014 - 09.02.2019</duration><status>Završio</status><financ_value>116.132,46 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>3776, 3576, 559, 3672, 6232, 17773, </team_members_id><team_members_names><![CDATA[Ivan Bilić, Maja Matulić, Isidoro Feliciello, Li Wu, Mladen Paradzik, Luka Horvat, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[ hematopoietic stem cells, leukemia, Notch, Ikaros, non-coding RNA,differentiation, ]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The relevance of adult (somatic) stem cell research is increasing steeply with a growing number of human diseases shown to be curable by stem cell therapy. The present study plan aims the research towards the gene regulatory mechanisms that control hematopoietic stem cell (HSCs) homeostasis and differentiation, which is tightly regulated by an interplay of a number of transcription factors and environmental signals mediated by a Notch signaling pathway. Our group designed an experimental approach for studying the interaction of Notch signaling pathway with transcription factor genes associated with hematopoiesis with focus on Ikaros gene family. Our laboratory has established a diagnostic technique for quick and sensitive detection of aberrant Notch and Ikaros forms by single cell multiplex qRT-PCR, which is a unique tool enabling us to dissect the contribution of different members of the Ikaros and Notch families on differentiation and survival of hematopoietic cells in a context of regulation of expression of target genes as well as non-coding RNAs, since they maintain the spatial organization of chromosome structure and regulate cell commitment. Our results will improve diagnosis and risk stratification for leukaemia patients which will be an important aid in informed clinical decisions. Therefore the proposed project will substantially advance the field towards better therapeutic options and contribute significantly to the field of stem cell medicine. ]]></summary_en></project><project>
<id>1387</id><title_hr><![CDATA[Bioindikatori vodenih masa u Jadranu]]></title_hr><title_en><![CDATA[Bio-tracing Adriatic water masses (BIOTA)]]></title_en><user_id>2829</user_id><user_firstLast_name>Zrinka Ljubešić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2013-11</proposal_call><code>UIP-2013-11-6433</code><acronim><![CDATA[BIOTA]]></acronim><duration>01.10.2014 - 30.09.2017</duration><status>Završio</status><financ_value>124.597,26 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>2843, 4351, 4337, 451, 1519, 17842, 1305, </team_members_id><team_members_names><![CDATA[Damir Viličić, Petar Kružić, Sunčica Bosak, Jelena Godrijan, Marijana Miloslavić, Maja Mejdandžić, Ivana Bosnjak, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Adriatic Sea, climate changes, water mass tracers, cyanobacteria, coccolithophorids]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Interannual changes in the circulation patterns and water mass dynamics highly influence biogeochemical processes in the Adriatic Sea, consequently impacting the functioning of the Adriatic ecosystem. Specific phytoplankton ecological preferences drive their temporal and spatial distribution, reflecting their dependence on specific temperature ranges, light levels, nutrient availability and other environmental gradients. Hence, some phytoplankton taxa can be used as water mass tracers (biotracers). We hypothesize that picophytoplanktonic prokaryote Prochlorococcus and nanophytoplanktonic eukaryotes coccolithophores: Emiliania huxleyi and/or Gephyrocapsa oceanic are such organisms, and can be used for tracing water masses in the Adriatic. Here, we propose interdisciplinary study where oceanography, taxonomy of phytoplankton and molecular recognition are combined to detect and follow water masses. Two winter cruises in the southern Adriatic will be conducted with station positions and sampling depths defined in situ. Water mass detection will be based on pre-defined physical characteristics; however, we also plan to use optical measurements in conjunction with the proposed sampling to develop an optical based criterion for definition of the targeted water masses. Phytoplankton community will be assessed using multiple tools to confirm the presence and to determine distribution, abundance and diversity of the proposed biotracers in sampled water masses. With the variability and trends of the Adriatic circulation as well as the water mass characteristics brought on by changing climate, we believe that proposed study is timely and needed as it is offering a holistic and integrated approach to oceanography of the Adriatic. Most importantly, this study is proposing to develop a new set of interdisciplinary tools that will be essential for future research activities.]]></summary_en></project><project>
<id>1400</id><title_hr><![CDATA[Dijagnostika Interakcije lasera i hladne plazme]]></title_hr><title_en><![CDATA[Laser - Cold Plasma Interaction and Diagnostics]]></title_en><user_id>140</user_id><user_firstLast_name>Slobodan Milošević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-2753</code><acronim><![CDATA[LaCPID]]></acronim><duration>01.06.2014 - 31.05.2018</duration><status>Završio</status><financ_value>112.984,74 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut za fiziku]]></institution_hr><institution_en><![CDATA[Institute of Physics in Zagreb]]></institution_en><team_members_id>2611, 2867, 1500, 3306, 4041, 4033, 1271, 17797, </team_members_id><team_members_names><![CDATA[Marijan Bišćan, Robert Beuc, Damir Veža, Mladen Movre, Čedomil Vadla, Vlasta Horvatić, Nikša Krstulović, Dean Popović, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[low temperature plasmas, laser produced plasmas, cold plasmas, atmospherics plasmas, laser spectroscopy]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Cold and low-density plasmas are currently in focus of basic research worldwide due to many open questions regarding their complex nature and simultaneously due to their high potential for applications in various fields of research and technology. Plasmas can be produced by bombarding matter either with energetic electrons or with energetic photons. The first kind is related to use of various discharges and the second to use of powerful lasers. Our interest is in plasmas produced in vacuum, under low-pressure gas environment, at atmospheric air or on/within liquids. Discharges which we use range from electrodeless, single electrode to various designs of two electrode systems. Lasers we use are cw or pulsed nanosecond.  In our research special care will be devoted to tailoring the electron energy distribution functions as a key factor influencing plasma content and features. This is usually done by changing macroscopic plasma parameters - gas pressure, electrical fields and geometry of discharges. In this project we shall combine laser produced plasmas with discharge plasmas to achieve that goal. To understand the complex nature of plasma or processes of plasma interaction with other matter phases (gases, liquids and solids) basic approach is to perform plasma diagnostics by various types of optical and laser spectroscopies. To interpret findings we study basic atomic collision processes in plasmas and structure and spectra of various complexes formed within plasma (dimers, radicals etc). Modeling of various processes within cold plasmas and laser produced plasmas is performed in addition. In various applications in which plasma treatment of matter is used there is a need for in situ monitoring of processes both in plasma and at interfaces and therefore both spatial and temporal spectral resolution of applied detection techniques are important. We use classical emission and absorption laser spectroscopies and modern techniques such as a cavity ring-down spectroscopy.]]></summary_en></project><project>
<id>1402</id><title_hr><![CDATA[Utjecaj endemskog ratovanja na zdravlje kasnosrednjovjekovnih i ranonovovjekovnih populacija Hrvatske]]></title_hr><title_en><![CDATA[The effects of endemic warfare on the health of historic period populations from Croatia]]></title_en><user_id>2788</user_id><user_firstLast_name>Mario Šlaus</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-8100</code><acronim><![CDATA[Warandhealth]]></acronim><duration>30.06.2014 - 29.06.2018</duration><status>Završio</status><financ_value>79.615,20 eur</financ_value><scie_area_hr>Humanističke znanosti, Biomedicina i zdravstvo, Prirodne znanosti, </scie_area_hr><scie_area_en>Humanities, Biomedicine and health sciences, Natural sciences, </scie_area_en><scie_field_hr>Etnologija i antropologija, </scie_field_hr><scie_field_en>Ethnology and anthropology, </scie_field_en><institution_hr><![CDATA[Hrvatska akademija znanosti i umjetnosti]]></institution_hr><institution_en><![CDATA[Croatian Academy of Sciences and Arts]]></institution_en><team_members_id>2670, 567, 596, 2583, 2919, 3780, 1439, 19012, </team_members_id><team_members_names><![CDATA[Mario Novak, Željka Bedić, Vlasta Vyroubal, Marin Vodanović, Emma Lightfoot, Hrvoje Brkić, Mislav Čavka, Anita Adamić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[physical anthropology, bioarchaeology, paleopathology, health, war, osteological analyses, medieval period, Croatia]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Warfare has afflicted humankind throughout its history, and is a phenomenon that still fundamentally affects the modern world. Despite the fact that violence -related mortality is profoundly undercounted, violent conflict represents the third most important source of mortality around the world. Analyzing the effects that war had on health through the deep time perspective that archaeological investigations afford can provide unique data on the interactions between warfare, health and the environment and provided conclusions that are particularly relevant to disadvantaged communities throughout the developing world where most wars are currently being fought. This project assembles an international and multidisciplinary team of collaborators to conduct bioarchaeological investigations on two large composite skeletal samples from Croatia. The two composite series represent individuals who inhabited Croatia throughout: a) the Late Medieval period (1100-1400 AD) a period of relative prosperity and peace prior to the arrival of Ottoman Turks, and b) individuals who inhabited Croatia in the Historic period (1400-1700 AD) during which time the Ottoman Empire gradually expanded into East and Central Europe. The research will reconstruct Historic period health, diet, weaning practices, and disease and trauma patterns by comparing them with data from the Late Medieval period using bioarchaeological, paleopathological and stable isotope analyses of human burials from Croatia. The project is a collaboration between researchers and postgraduate students who specialize in bioarchaeology, paleopathology, paleodemography, paleodontology, radiology and stable isotope analyses from four institutions: the Croatian Academy of Sciences and Arts, the School of Dental Medicine of the University of Zagreb, the Department of Diagnostic and Interventional Radiology of the University Hospital Dubrava, and the McDonald Institute for Archaeological Research of the University of Cambridge. ]]></summary_en></project><project>
<id>1404</id><title_hr><![CDATA[Istraživanje dinamike Jadrana pomoću naprednih mjerenja i metode asimilacije podataka]]></title_hr><title_en><![CDATA[Exploring the Adriatic Sea Dynamics using Advanced Data Assimilation Methods and Measurements]]></title_en><user_id>357</user_id><user_firstLast_name>Ivica Janeković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-5928</code><acronim><![CDATA[ADAM-ADRIA]]></acronim><duration>01.08.2014 - 31.07.2018</duration><status>Završio</status><financ_value>64.803,54 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Geofizika, </scie_field_hr><scie_field_en>Geophysics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>1044, 1020, 1417, 2898, 3461, 3525, </team_members_id><team_members_names><![CDATA[Milivoj Kuzmić, Mathieu Dutour Sikirić, Zoran Pasarić, Miroslava Pasarić, Stjepan Ivatek-Šahdan, Hrvoje Mihanović, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Physical Oceanography, Data Assimilation, 4D-Var, ADCP, CTD profiler, Po river dynamics, Dense Water Dynamics, Adriatic Sea]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Using advanced numerical techniques and data assimilation (ROMS 4D-Var) at the same time with modern observations in a dynamically consistent way we aim to improve knowledge of the Adriatic Sea dynamics. During the project we will explore open questions in the field of physical oceanography of the Adriatic Sea: (I) dynamics of the dense water (DW), especially flow at the eastern side of the Adriatic Sea, (II) dynamics of the Po river outflow during stratified and vertically homogeneous conditions, as well as  (III) generation and dynamics of the sharp Istrian temperature and salinity front. In order to capture those phenomena  we plan to use advanced field observations (ADCPs, CTDs, towed CTD profiler, underway ship CTD), as well as high resolution nested numerical models. This type of measurements could arguably prove hypothesis on the importance of the East Adriatic DW contribution to the overall northern Adriatic DW budget. Measuring synchronously at all important entrances of the Kvarner Bay, we can determine time-evolving dynamics of this socio-economically important region. ROMS 4D-Var system is a powerful tool capable to provide insight into a optimal observation setup, predictability and limits of the linearized adjoint techniques for a shelf sea as the Adriatic. Results from the project could serve as basis for other research fields like ocean biology (DW bringing O2 at the bottom), chemistry or geology, or even applied like oil spills, integrated environmental planning where correct dynamics is of a crucial importance. The project team members come from the four institutions: Ruđer Bošković Institute, Faculty of Science, Croatian Meteorological and Hydrological Service, and Hydrographic Institute bringing unique competences for the proposed project to succeed.Last but not least, it is important to emphasize that after the project completion, all the insitu collected and model data will be made available to the scientific and applied research community.]]></summary_en></project><project>
<id>1406</id><title_hr><![CDATA[Uloga biotičkih čimbenika na vitalnost poljskoga jasena (Fraxinus angustifolia Vahl.) u poplavnim šumama Hrvatske]]></title_hr><title_en><![CDATA[The role of biotic agents on vitality of narrow-leafed ash (Fraxinus angustifolia Vahl.) in Croatian floodplain forests]]></title_en><user_id>2886</user_id><user_firstLast_name>Josip Margaletić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-4250</code><acronim><![CDATA[FRAXINPRO]]></acronim><duration>13.06.2014 - 12.06.2018</duration><status>Završio</status><financ_value>124.759,44 eur</financ_value><scie_area_hr>Biotehničke znanosti, Prirodne znanosti, Biomedicina i zdravstvo, </scie_area_hr><scie_area_en>Biotechnical sciences, Natural sciences, Biomedicine and health sciences, </scie_area_en><scie_field_hr>Šumarstvo, </scie_field_hr><scie_field_en>Forestry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet šumarstva i drvne tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Forestry and Wood Technology]]></institution_en><team_members_id>5650, 5656, 3892, 4036, 3748, 727, 4230, 3731, 3754, 5989, 6347, 5242, 5801, 5291, 5641, 6605, 4731, 3730, 5905, 3750, 6189, 1128, 17430, 19025, </team_members_id><team_members_names><![CDATA[Ante Tadin, Dario Baričević, Marko Vucelja, Linda  Bjedov, Milivoj Franjevic, Boris Hrašovec, Kristijan Tomljanović, Marijan Grubešić, Stjepan Mikac, Daniela Pilarska, Renata Pernar, Zrinka Štritof Majetić, Nenad Turk, Josipa Habuš, Petra Svoboda, Mario Ančić, Chandelier Anne, Danko Diminić, LUCIO MONTECCHIO, Marno Milotić, Thomas Cech, Davorin Kajba, Ivan Andrić, Jelena Kranjec, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Fraxinus angustifolia, vitality, biotic agents, floodplain forests, modelling]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Close to half of the Croatian flood plain forests (67 470 ha) are represented by narrow-leaf ash (Fraxinus angustifolia), covering 29 748 ha in major river basins. Respective welfare value of these forests amount to 6,4 billion €, 2,8 billion € being attributed exclusively to ash forests. Growing stock in narrow-leafed ash forests reaches 4,3 million m3, binding 11,8 million tons of carbon dioxide acting as an important carbon sink depository. Natural and artificial regeneration of ash stands is under direct impact of numerous biotic and abiotic factors, many of which seriously hamper the viability of ash. Insect pests, pathogenic fungi, large game ungulates and ruminantes and small rodent populations play dominant role in the complex processes of tree decline and stand deterioration. Additionally, in the course of recent Europe-wide dramatic spread of newly identified lethal disease on ashes (Chalara fraxinea), introduction of a highly damaging Emerald Ash Borer (Agrilus planipennis) on the eastern borders of Europe, and increased frequency of climatic extremes urge the need to intensify the research of this phenomena. Through an integrated, multidisciplinary approach, in the course of 4 years, the proposed research project targets on several critical aspects of aforementioned biotic detrimental factors analyzing them in the given area and time and aiming to provide a multitude of new details on the mechanisms of their impact. Modern methodological approach covers the following major research topics: presence, local impact and ash disease spread and host resistance tests; additive impact of ash defoliators in the course of recent decline and possibility to manage their populations via entomopathogenic organisms; the impact of small rodents on tree regeneration, acting also as an important human diseases reservoir; negative impact of large game in ash regeneration; geospatial and temporal analysis of major biotic influences in given forest communities. ]]></summary_en></project><project>
<id>1407</id><title_hr><![CDATA[Stohastičke metode u analitičkim i primijenjenim problemima]]></title_hr><title_en><![CDATA[Stochastic Methods in Analytical and Applied Problems]]></title_en><user_id>145</user_id><user_firstLast_name>Zoran Vondraček</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-3526</code><acronim><![CDATA[SMAAP]]></acronim><duration>01.09.2014 - 31.08.2018</duration><status>Završio</status><financ_value>58.289,35 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>522, 790, 570, 740, 781, 987, 793, 760, 1087, 853, 635, 1447, 999, 577, 19109, 19068, </team_members_id><team_members_names><![CDATA[Hrvoje Šikić, Bojan Basrak, Miljenko Huzak, Vjekoslav Kovač, Ante Mimica, Nikola Sandrić, Danijel Krizmanić, Ivana Geček Tuđen, Azra Tafro, Drago Špoljarić, Vanja Wagner, Tvrtko Tadić, Kristina Ana Škreb, Snježana Lubura, Hrvoje Planinić, Stjepan Šebek, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[stochastic methods, stochastic processes, Markov processes, martingales, heavy tails, point processes, branching processes]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[In this project we apply modern stochastic methods to study a number of analytical and applied problems. Many phenomena in science and everyday life exhibit inherent uncertainty. We commonly use stochastic models to describe such behaviour and rely on stochastic methods to gain insights, make forecasts or inference about them. Various stochastic methods have appeared over the years in biology, medicine, biomedicine, geology, climatology, social sciences, finance and insurance, and many other scientific fields. The area of mathematics that lies in the background is probability theory, in particular, theory of stochastic processes. It is a rich mathematical theory with proven potential to solve not only applied problems, but also some quite theoretical problems coming from other areas of mathematics.The problems that we plan to study can be broadly divided into four groups: 1. Analysis and potential theory of Markov processes, 2. Stochastic methods in modelling heavy tailed phenomena, 3. Stochastic methods in harmonic analysis, and 4. Stochastic methods in biomedical and social sciences problems. This choice of problems is influenced by importance in the current international research as well as the background and expertise of members of our team. The goal of the project is to advance understanding of the role of randomness in each of these four settings. The unifying feature behind our approach to these problems is common stochastic methods in their analysis. These methods include, but are not limited to, martingale methods, point processes and random measure methods, potential-theoretic methods (both probabilistic and analytic), Markov processes methods, methods from the Dirichlet form theory, stochastic integrals, diffusion processes, branching processes and measure-valued processes methods, time-series methods, wavelets and methods for statistical inference.]]></summary_en></project><project>
<id>1415</id><title_hr><![CDATA[Dizajn, sinteza i evaluacija novih protuotrova kod trovanja živčanim bojnim otrovima i pesticidima]]></title_hr><title_en><![CDATA[Design, synthesis and evaluation of new antidotes in nerve agent and pesticide poisoning]]></title_en><user_id>872</user_id><user_firstLast_name>Zrinka Kovarik</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-4307</code><acronim><![CDATA[CHOLINESTERASE]]></acronim><duration>01.09.2014 - 31.08.2018</duration><status>Završio</status><financ_value>132.715,75 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut za medicinska istraživanja i medicinu rada]]></institution_hr><institution_en><![CDATA[Institute for Medical Research and Occupational Health]]></institution_en><team_members_id>982, 991, 489, 1224, 601, 411, 657, 3033, 3076, 5926, 17747, </team_members_id><team_members_names><![CDATA[Maja Katalinić, Anita Bosak, Goran Šinko, Gordana Mendaš Starčević, Vladimir Vinković, Nikolina  Maček Hrvat, Nikola Maraković, Suzana Žunec, Ana Lucić Vrdoljak, Zoran Radić, Tamara Zorbaz, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[acetylcholinesterase, butyrylcholinesterase, bioscavengers, prophylaxis, in silico drug-design, oximes, bronchodilatators]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Our main goal is to develop new compounds to serve as more efficient antidotes and improve the treatment of highly toxic organophosphorus (OP) compound poisoning. OP compounds used as pesticides account for over 3,000,000 registered accidental or deliberate cases of poisoning per year worldwide. Furthermore, OPs known as nerve agents (soman, sarin, tabun, VX) present a threat in terrorist attacks and conflicts, as was the case recently in Syria. The main targets of OP compounds are cholinesterases: acetylcholinesterase (AChE), the essential enzyme in neurotransmission, and butyrylcholinesterase (BChE), its back-up enzyme. However, the antidotes currently in use, which act as reactivators of inhibited AChE, were empirically synthesized before the two enzyme’s crystal structures were resolved. Due to structural requirements, their binding affinity and reactivation rate have not been well-balanced. This project utilizes new compounds to gain a better understanding of the mechanistic basis of the limitations of reactivation and find new effective leads for further in vivo study. We will combine several approaches, including: a study of the finely tuned interplay between these two sister enzymes, computational and experimental studies of cholinesterase interactions with a wide range of ligands defining favourable characteristic for potential new antidotes, in silico design of novel compounds that will direct the subsequent synthesis of selected leads, and thorough in vitro and in vivo experimental evaluation guided by strict cost-benefit criteria. Such a comprehensive approach will enable us to test a wide selection of candidates in a more reliable manner and obtain unambiguous data for further enhancements of the antidotal treatment. This will also enable us to explore other possible OP treatments such as highly-effective bioscavengers. Many of the findings that would arise from this project should have an impact that reaches far beyond the level of cholinesterases.]]></summary_en></project><project>
<id>1417</id><title_hr><![CDATA[MOLEKULARNI MEHANIZMI POVEĆANJA OSJETLJIVOSTI NA PROTUTUMORSKE LIJEKOVE STANICA KARCINOMA DOJKE I MELANOMA ČOVJEKA UTIŠAVANJEM INTEGRINA]]></title_hr><title_en><![CDATA[MOLECULAR MECHANISMS OF CHEMOSENSITISATION OF HUMAN BREAST CARCINOMA AND MELANOMA CELL LINES BY SILENCING OF INTEGRINS]]></title_en><user_id>1211</user_id><user_firstLast_name>Andreja Ambriović Ristov</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-2465</code><acronim><![CDATA[INSILCELL]]></acronim><duration>01.09.2014 - 31.08.2018</duration><status>Završio</status><financ_value>132.533,26 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>1380, 3536, 3899, 2888, 3147, 420, 6232, </team_members_id><team_members_names><![CDATA[Maja Osmak, Mario Cindrić, Sanjica Rak, Nikolina Stojanović, Tihana De Zan, Ana Dekanić, Mladen Paradzik, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[breast cancer, melanoma, signalling pathways, anticancer drug resistance, focal adhesion, migration, invasion]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The recognition of molecular mechanisms involved in drug resistance may improve basic knowledge of signalling pathways involved in resistance to anticancer drugs and also improve outcomes in patients with drug-resistant cancers that have poor prognosis, such as triple negative breast cancer (TNBC) and metastatic melanoma. Integrins are cell surface molecules that mediate sensitivity to anticancer drugs, migration and invasion, and therefore represent a suitable target for therapy. This proposal investigates the molecular mechanism behind knockdown of integrins alpha v beta 3, alpha v beta 5, alpha v beta 6, alpha 3 beta 1, alpha 4 beta 1 and alpha 5 beta 1 using integrin subunit specific siRNAs (beta 3, beta 5, beta 6, alpha v, alpha 3, alpha 4 or alpha 5) and the ability of such a treatment to sensitise TNBC and melanoma cell lines to anticancer drugs paclitaxel, vincristine and cisplatin. Our next goal is to identify how specific integrin knockdown influences cell migration and invasion. The focal adhesions (FA) are sites of attachment between cells and extracellular matrix which may mediate differential cell responses by variation of FA protein composition. Therefore, the FA protein composition will be investigated before and upon integrin silencing using proteomics methodology. We will monitor formation and temporal evolution of FA in living cells during spreading or migration using reflection interference contrast microscopy (RICM). On the basis of these data, several signalling pathways will be proposed and their involvement in sensitivity to anticancer drugs, migration and invasion will be experimentally verified. Our data will contribute to the knowledge on integrin signalling pathways, structure and function of focal adhesions. The understanding of integrin pathways involved in sensitivity to anticancer drugs, migration and invasion processes may provide novel insights into biology of these cancer cells and identify new target molecules in TNBC or melanoma.]]></summary_en></project><project>
<id>1421</id><title_hr><![CDATA[Transformacije kolektivnih i individualnih identiteta u Dubrovačkoj Republici od kasnog srednjeg vijeka do 19. stoljeća]]></title_hr><title_en><![CDATA[Transformations of the Collective and Individual Identities in the Dubrovnik Republic from the Late Middle Ages until the Nineteenth Century]]></title_en><user_id>393</user_id><user_firstLast_name>Nenad Vekarić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-5106</code><acronim><![CDATA[COLINDA]]></acronim><duration>01.07.2014 - 30.06.2018</duration><status>Završio</status><financ_value>78.306,46 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Povijest, </scie_field_hr><scie_field_en>History, </scie_field_en><institution_hr><![CDATA[Hrvatska akademija znanosti i umjetnosti]]></institution_hr><institution_en><![CDATA[Croatian Academy of Sciences and Arts]]></institution_en><team_members_id>384, 386, 389, 398, 481, 458, 726, 739, 430, 1091, 1097, 1115, 1112, 1254, 330, </team_members_id><team_members_names><![CDATA[Ivana Lazarević, Nella Lonza, Rina Kralj-Brassard, Relja Seferović, Vesna Miović, Stanislava (Slavica) Stojan, Lovro  Kunčević, Zdenka Janeković Roemer, Irena Ipšić, Antun Koncul, Kristina Puljizević, Marija Gjurašić, Marinko Marić, Štefica Curić Lenert, Zrinka Pešorda Vardić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Dubrovnik, Identity, Middle Ages, Early Modern Period, cultural history]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The proposed project is an interdisciplinary study of various forms of identity in the Republic of Dubrovnik during almost half a millennium of its independent statehood (mid 14th – early 19th century). Adopting a broad perspective it will take into account most diverse aspects of identity, such as social, political, religious, ethnic, or individual, as well as their interactions. This requires investigation of diverse historical sources which range from texts (e.g. historiography, diplomatic correspondence, notary records), to social practices (e.g. ritual) or urban topography and visual arts. Besides such comprehensiveness, another important novelty of the project is its chronological scope. It takes into account long period of almost half a millennium, thereby disregarding the conventional divide between the Middle Ages and the Early Modern Period, which will enable valuable insights into long term (dis)continuities. Yet another important novelty is that the project focuses on a premodern city-state, a type of community relatively neglected in the field of identity studies mostly focused on modern period and national states. Finally, the project will also adopt a strongly comparative perspective, investigating the (dis)similarities between Dubrovnik and other Mediterranean cities.Since the enterprise of this scope necessarily involves specialists in different fields and methodologies, the project assembles an interdisciplinary team led by the Academician Nenad Vekarić. It consists of ten scientists, two postdoctoral researchers and four doctoral students. The project proposes to publish more than 10 scientific books, numerous articles, and organize four workshops. Besides offering the answer to an important scientific problem, the main objective of the project is to present to the international audiences the less known but important case of Dubrovnik, thus contributing to the visibility and networks of Croatian scholars. ]]></summary_en></project><project>
<id>1422</id><title_hr><![CDATA[Aproksimacija ovisna o konfiguraciji u nelinearnoj analizi konstrukcija metodom konačnih elemenata]]></title_hr><title_en><![CDATA[Configuration-dependent Approximation in Non-linear Finite-element Analysis of Structures]]></title_en><user_id>527</user_id><user_firstLast_name>Gordan Jelenić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-1631</code><acronim><![CDATA[CANFAS]]></acronim><duration>01.09.2014 - 31.08.2018</duration><status>Završio</status><financ_value>124.557,44 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Temeljne tehničke znanosti, </scie_field_hr><scie_field_en>Basic engineering sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Građevinski fakultet u Rijeci]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Civil Engineering]]></institution_en><team_members_id>1064, 1014, 906, 856, 3167, 19011, 17756, 22702, </team_members_id><team_members_names><![CDATA[Paulo Šćulac, Dragan Ribarić, Leo Škec, Maja Gaćeša, Edita Papa Dukić, Nina Čeh, Sara Grbčić, Miran Tuhtan, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[non-linear structural analysis, finite-element method, configuration-dependent approximation, beams, shells, dynamics]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[This proposal explores the configuration-dependent interpolation as a novel, unorthodox and remarkably promising expansion of the framework within which the non-linear finite-element method has been traditionally contained. The basic idea underlying the project stems from an apparent disparity between the rather advanced extensions of the traditional linear finite-element principles to non-linear problems and the fact that the key finite-element concept – that of interpolation of the unknown functions – is surprisingly kept mostly constant, i.e. configuration-independent. Enabling the finite-element approximation to become configuration-dependent is motivated by the existing need to improve the current non-linear finite-element procedures, in particular for mechanical problems defined on non-linear manifolds. This principle is presented as the general concept providing viable novel development paradigm with obvious benefits for a wider class of mechanical problems. The configuration-dependent approximation to be designed shall obey the essential convergence requirements, with its extra flexibility (arising from the potential of the new approximation to vary with the configuration) employed to improve the solution in some clearly defined manner. In particular, during the design process, the following two basic principles will be consistently adhered to:(i) In the limiting case where the non-linear mechanical problem becomes linear, the configuration-dependent approximation sought must coincide with a known reference interpolation for linear analysis.(ii) In a general non-linear situation, the configuration-dependent approximation should preserve a set of selected mechanical or mathematical properties of equilibrium or motion defined beforehand.In this way, a variety of finite-elements for static and dynamic analysis will be derived.]]></summary_en></project><project>
<id>1423</id><title_hr><![CDATA[Inovativno pametno poduzeće]]></title_hr><title_en><![CDATA[Innovative Smart Enterprise]]></title_en><user_id>2921</user_id><user_firstLast_name>Ivica Veža</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-1353</code><acronim><![CDATA[INSENT]]></acronim><duration>01.09.2014 - 31.08.2018</duration><status>Završio</status><financ_value>95.825,87 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, </scie_field_hr><scie_field_en>Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Fakultet elektrotehnike, strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Electrical Engineering, Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>3561, 5080, 4743, 5276, 5799, 5752, 18966, 18965, 18956, 17852, </team_members_id><team_members_names><![CDATA[Marko Mladineo, Željko Stojkić, Zoran Babić, Nikola Gjeldum, Stipe Čelar, Boženko Bilić, Nikola Banduka, Igor Bošnjak, Mii Turić, Ivan Peko, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[innovation, smart enterprise, learning factory, production systems, business model]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The introduction of the Internet of Things and Services into the manufacturing environment is ushering in a fourth industrial revolution: Industry 4.0. This new type of industry is based on Smart Factory model or Smart Enterprise. The main features of Smart Enterprise can be summarized into the following: smart personalized product, product and service provider, and high level of collaboration.Manufacturing is today, as it always has been, a cornerstone of the economy of developed nations. An important advantage of manufacturing is that it calls on the skills of everyone from entry-level factory workers to scientists, engineers, and business professionals. Hence, main focus of this project will be Manufacturing Enterprises. Vision of Innovative Smart Enterprise for next generation manufacturing can be summarized into following features: Lean, Flexible, Agile, Efficient, Responsive, Information Enabled, Predictive, and Safe. All these features result with long term sustainability.The main objective of this project is to develop Croatian model of Innovative Smart Enterprise (HR-ISE model). Hence, a profound research will be performed to describe current state of Croatian manufacturing enterprise. It will be the answer on the question: “Where are we?”Furthermore, a synthesis of analysis of Croatian manufacturing enterprises will be done through development of HR-ISE model. It will be the answer on the question: “Where we want to be?”Finally, a special learning environment will be established: Learning Factory. It will be a place in which transfer of developed HR-ISE model to the economy subjects will be achieved. It will be the answer on the question: “How can we get there?”Results of this project will be of the highest value for “fallen” Croatian industry. The development of HR-ISE model and its transfer to economy can have strong impact on recovery of Croatian industry, and it can significantly improve competencies and capabilities of Croatian enterprises.]]></summary_en></project><project>
<id>1427</id><title_hr><![CDATA[Kompetencijski profil akademske profesije: između novih zahtjeva i mogućnosti]]></title_hr><title_en><![CDATA[Academic Profession Competence Framework: Between New Requirements and Possibilities]]></title_en><user_id>380</user_id><user_firstLast_name>Jasminka Ledić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-2004</code><acronim><![CDATA[APROFRAME]]></acronim><duration>01.06.2014 - 31.05.2017</duration><status>Završio</status><financ_value>38.783,57 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Pedagogija, </scie_field_hr><scie_field_en>Pedagogy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Filozofski fakultet u Rijeci]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>2588, 500, 18914, 18911, </team_members_id><team_members_names><![CDATA[Bojana Ćulum, Marko Turk, Marija Brajdić Vuković, Bojana Vignjevic, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[higher education, academic profession, competence framework, academic roles, higher education policy]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Changes in social environment indicate the need for a redefinition of the academic profession’ traditional role and for its more comprehensive understanding, which leads to the requirements for the development of new competences. Research results indicate the increased scope of workload and demands for new approaches to teaching, disharmony between teaching and research, increasing administrative duties, and the insistence on a stronger connection between the academic community and social environment.This project aims to determine how academics in Croatia assess the relevance of various competences, and how they assess, perceive and interpret possession of various competences that shape contemporary academic profession. It is expected that the research results in a proposal of the academic profession’ competence framework.In the research quantitative and qualitative methodological approach (survey and semi-structured interview) will be used. The survey consists of the competence framework elements which are to be evaluated by the participants in terms of the assessment of their (1) relevance and (2) possession. The interviews will explore the deeper perception of academics and challenging issues within the framework, and gain a ‘holistic’ (comprehensive, systemic, integrated) understanding of context, while capturing data on the participants perceptions ‘from the inside’.The final definition of an integrated competence framework which includes different dimensions of the academic profession is an original research contribution. Bearing in mind that the research of the academic profession is neglected in the national research discourse, the results of this study will also be a starting point for defining recommendations for (national) educational policies. This will particularly apply to profiling the academic profession in the context of recent strategic directions in Croatia, in accordance with the requirements of the international scientific community.]]></summary_en></project><project>
<id>1431</id><title_hr><![CDATA[Anaerobni kapaciteti  u udaračkim borilačkim sportovima]]></title_hr><title_en><![CDATA[Anaerobic capacities in kicking combat sports]]></title_en><user_id>784</user_id><user_firstLast_name>Dražen Čular</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2013-11</proposal_call><code>UIP-2013-11-6524</code><acronim><![CDATA[ACIKCS]]></acronim><duration>15.06.2014 - 14.03.2018</duration><status>Završio</status><financ_value>52.659,13 eur</financ_value><scie_area_hr>Društvene znanosti, Biomedicina i zdravstvo, Tehničke znanosti, </scie_area_hr><scie_area_en>Social sciences, Biomedicine and health sciences, Technological sciences, </scie_area_en><scie_field_hr>Kineziologija, </scie_field_hr><scie_field_en>Kinesiology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Kineziološki fakultet]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Kinesiology]]></institution_en><team_members_id>3449, 1463, 3312, 4560, 3813, 4737, 17896, 18978, </team_members_id><team_members_names><![CDATA[Alen Miletić, mirjana milić, Goran Kuvačić, Vladimir Ivancev, TEA BEŠLIJA, Damir Zubac, Luka Pezelj, Johnny Padulo, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[anaerobic capacity, combat sport, test construction, taekwondo, karate, kickboxing, fitness  tests,  ]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The main aim of the project is to construct and validate a measuring instrument of good metric characteristics and with high applicability that will, in a quality way, describe the level of specific anaerobic capacities in kicking combat sports (taekwondo, karate, kickboxing). Due to the complexity of the problems regarding the object of research, and in case the newly constructed test does not show satisfactory metric characteristics, a secondary aim is set which entails revalidation and selection of one or more existing “non-specific” tests which will be proven appropriate for each sport after testing the metric characteristics. The project is designed as a research in duration of 36 months. For the purposes of realization of the aims set, the research will be conducted on a sample of 300 subjects minimum, divided into subsamples according to sport, gender and age category (cadets, juniors, seniors). The project consists of three phases. In the first phase a Web page and computer application will be created for: input, storage, reviewing and monitoring of subjects and results, and, based on a pilot study and previous findings, a certain number of the existing “non-specific” measuring instruments will be selected. In the second phase of the project data will be collected on anthropometric characteristics and the level of anaerobic capacities of the subjects will be measured by field tests with confirmed metric characteristics. At the same time, the construction of a new specific measuring instrument will begin during the second phase. The third phase of the project includes the testing of metric characteristics of the newly constructed specific field test for assessing anaerobic capacities in kicking combat sports, as well as the selection of the existing tests appropriate for practical application on a specific sample. After the project is finished, selection normative according to sport, gender and age category will be created based on the obtained results.]]></summary_en></project><project>
<id>1440</id><title_hr><![CDATA[Dokumentiranje i interpretiranje najstarijih razdoblja hrvatskoga jezika]]></title_hr><title_en><![CDATA[Documentation and Interpretation of the Earliest Croatian]]></title_en><user_id>995</user_id><user_firstLast_name>Amir Kapetanović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-2698</code><acronim><![CDATA[DOCINEC]]></acronim><duration>01.07.2014 - 30.06.2018</duration><status>Završio</status><financ_value>56.539,25 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filologija, </scie_field_hr><scie_field_en>Philology, </scie_field_en><institution_hr><![CDATA[Institut za hrvatski jezik]]></institution_hr><institution_en><![CDATA[Institute of Croatian Language]]></institution_en><team_members_id>3723, 5648, 5864, 5965, 3726, 6131, 5332, </team_members_id><team_members_names><![CDATA[Dunja Brozović Rončević, Željka Brlobaš, Vuk-Tadija Barbarić, Saskia Elisabeth Pronk-Tiethoff, Tijmen Pronk, Dubravka Ivšić, Branimir Brgles, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Old Croatian, Proto-Slavic, onomastics, earliest linguistic attestations, loanwords, issogloses]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The oldest Slavic language attestations on Croatian territory date from two periods - the first which saw the disintegration of Common Slavic (9th-11th c.), and the second which saw the beginnings of the Croatian language (12th-13th c.). This Slavic vernacular, which was the direct predecessor of present-day Croatian, coexisted with the liturgical Croatian Church Slavic, whose oldest written texts can be dated to the 11th c. The earliest attestations of the Croatian language are scattered throughout written sources of various nature, from individual words found in Latin and Church Slavic texts, glosses, and notes in the margins of medieval codices to Glagolitic epigraphs. This language has not yet been analyzed in its entirety.The backbone of the project will be formed by a corpus of the earliest attested Croatian lexical data. Such a corpus does not yet exist. This early Croatian corpus will reflect the development of the languages between the 9th and 13th centuries, some of the earliest isoglosses between Croatian and other Slavic languages, as well as some of the earliest Croatian dialectal isoglosses and interaction with western European – especially Romance and Germanic – and eastern European cultural and linguistic entities. The earliest onomastic data of Slavic origin plays an important role in this research.The research will be conducted using the traditional methods and tools of historical linguistics, such as text analysis and interpretation and the comparative method. The research team consists of four researchers and five junior researchers from a number of academic institutions (Zagreb, Zadar, Leiden).The aims of the proposed project are: (1) to create a complete collection of the oldest attestations of the Croatian language; (2) to improve our understanding of the structural changes in early Croatian and the rise of the earliest isoglosses within Croatian; (3) to place the beginnings of the Croatian language in a wider Slavic and non-Slavic context.]]></summary_en></project><project>
<id>1442</id><title_hr><![CDATA[Mulitidisciplinarni pristup otkriću lijekova s ciljanim djelovanjem na matične stanice tumora – uloga transporta kalija ]]></title_hr><title_en><![CDATA[A multidisciplinary approach to discover selective drugs targeting cancer stem cells: The role of potassium transport ]]></title_en><user_id>613</user_id><user_firstLast_name>Marijeta Kralj</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-5660</code><acronim><![CDATA[MultiCaST]]></acronim><duration>01.10.2014 - 28.02.2019</duration><status>Završio</status><financ_value>131.589,36 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo, Prirodne znanosti, Biotehničke znanosti, </scie_area_hr><scie_area_en>Biomedicine and health sciences, Natural sciences, Biotechnical sciences, </scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>629, 859, 2607, 3445, 647, 3806, 1421, 698, 17804, 21401, </team_members_id><team_members_names><![CDATA[Marko Marjanović, Katja Ester, Irena Martin-Kleiner, Ana-Matea Mikecin, Lidija Uzelac, Tomislav Šmuc, Fran Supek, Kata Majerski, Iva Guberović, Marija Ćosić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[cancer stem cells, potassium transport, salinomycin, crown ethers, ion channels, ABC transporters, predictive QSAR modeling, drug discovery, therapy]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Targeting cancer stem cells (CSC), rather than cancer cells in general, is a novel and highly promising strategy for cancer treatment. The defining characteristics of CSC are self-renewal, propagation into heterogeneous lineages of cancer cells, and increased resistance to chemotherapy, thus, attacking the CSC should abolish a tumor&#39;s ability to recur or metastasize. Recently, a natural potassium ionophore salinomycin was identified as one of a few available CSC-selective substances, but the precise mechanism of its selectivity remains elusive. Based on hypothesis that the potassium transport is an important process of CSC biology, the objective of the proposed research is to understand fundamental processes of CSC-resistance to therapy and to discover novel compounds with ion homeostasis-modulating properties to selectively target CSC. Project methodology orchestrates research in three principle areas and their close interactions, covering synthesis and characterization of molecules (chemistry), assessment of their activity in biological models (biology, medicine) and computer-aided drug design (computational sciences). We’ll focus on salinomycin and a series of proprietary crown ether compounds, which will be optimized and developed. Their efficacy/selectivity and influence on drug transporters P-gp- and/or ABCG2-mediated efflux of chemoterapeutics will be assessed, as well as the toxicity and in vivo activity of the most promising compound. Deploying cutting-edge techniques in cell and molecular biology, bioimaging, molecular electrophysiology and transgenic cell lines (e.g. a unique CSC model - HMLEshEcad cells) we will strive to recognize novel biomarkers for identification and enrichment of CSC, related to abnormal potassium transport regulation that promote acquisition of CSC phenotype and/or influence their proliferation, death and migratory potential. The ultimate aim is to translate this knowledge into innovative mechanism-based therapeutic approaches. ]]></summary_en></project><project>
<id>1445</id><title_hr><![CDATA[Kateterska denervacija pulmonalnih arterija u liječenju primarne i sekundarne plućne hipertenzije]]></title_hr><title_en><![CDATA[CATHETER DENERVATION OF PULMONARY ARTERIES IN THE TREATMENT OF PRIMARY AND SECONDARY PULMONARY HYPERTENSION]]></title_en><user_id>315</user_id><user_firstLast_name>Aleksander Ernst</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-2505</code><acronim><![CDATA[CADOPA]]></acronim><duration>01.07.2014 - 30.06.2018</duration><status>Prekinut</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Clinical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>1334, 1092, 1021, 985, 3393, 3452, </team_members_id><team_members_names><![CDATA[Jadranka Šeparović Hanževački, Mladen Vidovich, Boško Skorić, Joško Bulum, Maja Strozzi, Miroslav Samarzija, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[idiopathic pulmonary hypertension, secondary pulmonary hypertension, radiofrequency denervation, cryodenervation, pulmonary arteries]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The role of neural reflexes in the mediation and development of idiopathic pulmonary artery hypertension (IPAH) and secondary pulmonary artery hypertension (SPAH) has not been adequately investigated. The existence of a pulmopulmonary baroreceptor reflex that originates in the large pulmonary branches, unrelated to the vagus nerve has been reported (1,2,3).Very recently, experimentally induced acute pulmonary hypertension in 10 Mongolian dogs was completely abolished by radiofrequency pulmonary artery denervation at the main bifurcation area of the left pulmonary artery (4). Also,the effect of radiofrequency pulmonary artery denervation on functional capacity and hemodynamics showed significant reduction of mean pulmonary artery pressure (PAP) in 13 patients with IPAH not responding optimally to medical therapy(5).The aim of research proposal is to assess and compare the safety and efficacy of radiofrequency and cryodenervation of pulmonary arteries on decrease in pulmonary vascular resistance in 20 patients with IPAH (mean pulmonary artery pressure >25 mmHg) and in 20 patients with secondary pulmonary hypertension due to pulmonary disease or due to left heart disease not responding optimally to medical therapy.Already well established and aproved radifrequency and cryo ablation technology modified for pulmonary artery denervation will be utilized in proposed clinical trial of new indication. All procedures will be performed in the Clinical Hospital Center Catheterization laboratory. Proposed duration of the trial is 4 years. Expected scientific contribution of this clinical trial might provide invaluable impact on improvement of quality of life and possibly on a deacrease in mortality of patients with pulmonary hypertension. Positive results of proposed study might generate several scientific publications, doctoral theses and above all would strengthen the international scientist collaboration and reputation of Medical Faculty of University of Zagreb.]]></summary_en></project><project>
<id>1447</id><title_hr><![CDATA[Otkrivanje novih genetskih lokusa uključenih u regulaciju funkcije štitne i doštitne žlijezde]]></title_hr><title_en><![CDATA[Identification of new genetic loci implicated in regulation of thyroid and parathyroid function]]></title_en><user_id>118</user_id><user_firstLast_name>Tatijana Zemunik</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-1498</code><acronim><![CDATA[THYPARATHYFUNCTION]]></acronim><duration>15.09.2014 - 31.12.2018</duration><status>Završio</status><financ_value>112.814,39 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Split School of Medicine]]></institution_en><team_members_id>137, 588, 611, 262, 3571, 4137, 17479, 19036, 23035, </team_members_id><team_members_names><![CDATA[Maja Barbalić, Dubravka Brdar, Vesela Torlak, Bernarda Lozić, Ante Punda, Caroline Hayward, Antonela Boljat, Ivana Gunjača, Marijana Popović, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[thyroid function, parathyroid function, genetic variants, polymorphisms, genome-wide study, gene-environmental interaction, complex phenotypes]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Thyroid diseases affect up to 10% of the general population creating an important public health problem. Parathyroid diseases are less frequent but not insignificant. Thyroid hormones act on every tissue regulating cellular development, differentiation and metabolism. Parathyroid hormones control the amount of calcium in the blood. The expression of thyroid and parathyroid hormones/antibodies is under polygenic control and influenced by environmental factors. The aim of this study is to identify genetic loci that are associated with levels of thyroid/parathyroid hormones and antibodies that will advance our understanding of the genetic basis of their function and thus provide additional knowledge relevant to clinical outcomes.  We will perform genome-wide association analysis of thyroid and parathyroid hormones/antibodies on 1,000 individuals from Split region (participants from the 10,001 Dalmatians project). The thyroid and parathyroid hormones/antibodies that are planned to be analysed are: free triiodothyronine, free thyroxine, thyroid-stimulating hormone, thyroglobulin, thyroid microsomal antibody titer, thyroglobulin antibody titer and parathiroid hormone. In addition, detailed anamnestic data and phenotype measurements already taken from study participants will be used in realization of second and third project objectives: investigation of relevant gene-environment interactions and determination of phenotype-phenotype correlation. We plan to follow-up interesting findings in additional 2,000 individuals and in datasets sought through international collaboration.Outcomes of such comprehensive approach will be generation of a new knowledge of genetic background, gene-environment interaction and phenotype-phenotype correlation associated with thyroid and parathyroid function that will lead to better understanding of biological pathways and clinically relevant disorders related to their function. The obtained results will promote excellence of Croatian research.]]></summary_en></project><project>
<id>1451</id><title_hr><![CDATA[Otkrivanje novih proteinskih interakcija kao podloga za nove pristupe liječenju melanoma čovjeka]]></title_hr><title_en><![CDATA[New protein networks for novel therapeutic avenues in human melanoma]]></title_en><user_id>649</user_id><user_firstLast_name>Neda Slade</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-1615</code><acronim><![CDATA[ProNetMel]]></acronim><duration>01.09.2014 - 31.01.2019</duration><status>Završio</status><financ_value>120.558,76 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>1107, 3089, 942, 3401, 1322, 712, 1033, 2812, 1470, 17835, 15915, </team_members_id><team_members_names><![CDATA[Maja Herak Bosnar, Sonja Levanat, Vesna Musani, Mladen Jokić, Anđela Horvat, Petar Ozretić, Diana Car, Božena Šarčević, Ivan Milas, Nikolina Hanžić, Vjekoslav Tomaić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[melanoma, protein interactions, p53, p73, nm23, Gli]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Metastatic melanoma represents a major clinical problem due to rising incidence and resistance to available therapies. Therefore, there is a necessity for developing novel molecular approaches to treat this disease. Unlike other tumors, in melanoma p53 is relatively rarely mutated. However, overexpressed p53 fails to function as a tumor suppressor and tumor cells continue to proliferate and spread. This suggests that regulation of p53 activity depends on the interplay between p53 and its binding partners. Based on current state of knowledge, we hypothesize that p53 function in malignant melanoma might be altered through the interactions with p53 small molecular weight and p73 isoforms, nm23/NDPK and Gli families of proteins. Thus we will search for p53 protein binding partners in melanoma. The interactions identified by mass spectrometry will be further confirmed using microarray-based approaches and co-immunoprecipitation techniques. Furthermore, the expression profile of genes/proteins of interest in panel of melanoma cell lines and melanoma tissue samples will be investigated. The potential impact of the identified p53 interacting partners on its transcriptional activity and the stimulation of apoptosis will be determined. The depletion of partners using siRNA technology would confirm the involvement of selected proteins on p53 activity. The subcellular localization of the proteins in complex will be revealed by advanced fluorescent microscopy methods on state-of-the-art instrumentation what would give us the insight on dynamics of their interactions. The proposed research could provide a possible explanation why p53 function in melanoma is abrogated. The aim of this project is to determine the complexity of p53 interactions and their role in the onset and progression of human melanoma and offer new, innovative solutions in diagnosis, prognosis and therapy.]]></summary_en></project><project>
<id>1456</id><title_hr><![CDATA[Automorfne forme, reprezentacije i primjene]]></title_hr><title_en><![CDATA[Automorphic forms, representations, and applications]]></title_en><user_id>820</user_id><user_firstLast_name>Goran Muić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-9364</code><acronim><![CDATA[Automorphic forms]]></acronim><duration>01.07.2014 - 30.06.2018</duration><status>Završio</status><financ_value>50.169,22 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>863, 831, 850, 890, 1154, 1000, 1079, 901, 17779, </team_members_id><team_members_names><![CDATA[Darija Brajković, Iva Kodrnja, Ivan Matić, Neven Grbac, Marko Tadić, Igor Ciganović, Marcela Hanzer, Nevena Jurčević Peček, Sonja Žunar, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[automorphic forms, representations, Eisenstein series, cuspidal forms, theta correspondence]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Recent and major breakthrough in the Langlands programme is a proof of existence endoscopic transfer of representations both local and global automorphic from split classical groups to GL(n) proved mainly by Arthur. Our research proposal  fits very well with this recent development. First of all, the work of Arthur has its local application in  the classification of representations of discrete series that was done by Moeglin and Tadić. Based on those results we plan to pursue the following investigations in the representation theory of p-adic groups.  We would like to compute the Jacquet modules of discrete series representations completely.This will help us understand representations parabolically induced from those discrete series (generalized principal series) completely. This will have consequence on the problems of determination of complementary series for classical groups a problem related to the classification of unitary representations. Results of Gan, Savin and Ichino will help us extend some of those results to metaplectic groups. This will have important consequence on the determination of theta correspondence for dual pairs consisting of odd orthogonal and metaplectic groups such as explicit determination of all theta lifts. In the theory of automorphic forms, we would like to understand the construction of Arthur and Moeglin more explicitly. This will construct new series of square integrable representations; some special cases were obtained earlier by Muić, and Muić and Hanzer.This will give locally many interesting unitary representations which are more complicated than that has appeared in earlier works of Speh, Rogawski, Tadić, Muić, Savin, and Hanzer. We will apply those methods to study cohomology and poles of automorphic L-functions. ]]></summary_en></project><project>
<id>1458</id><title_hr><![CDATA[Razvoj voltametrijskih metoda za karakterizaciju prirodnih antioksidansa]]></title_hr><title_en><![CDATA[Development of voltammetric methods for the characterisation of natural antioxidants]]></title_en><user_id>442</user_id><user_firstLast_name>Šebojka  Komorsky-Lovrić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-2072</code><acronim><![CDATA[DVMCNA]]></acronim><duration>01.07.2014 - 30.06.2017</duration><status>Završio</status><financ_value>14.599,51 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>1099, 595, 438, 17762, </team_members_id><team_members_names><![CDATA[Ivana Novak Jovanović, Dijana Jadreško, Milivoj Lovrić, Lara Čižmek, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[voltammetry, antioksidans, radicals, squave wave, simulations]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Oxidant is an ion or a compound that reacts with a certain component of a living cell and oxidizes it. The reactive oxygen species produced in cells include hydrogen peroxide, hypochlorous acid, hydroxyl radical and superoxide anion. Antioxidant is a foreign substance that reacts with the oxidant faster than the components of the cell. An imbalance between oxidants and antioxidants in favour of the oxidants is termed oxidative stress. Antioxidants act as free radical scavengers and therefore can lower the risk of numerous degenerative diseases by preventing damages caused by free radicals. Fruits and vegetables are the major sources of antioxidants in human diet. Several natural compounds found in food, such as polyphenols, vitamins A and E, and some carotenoids, have been found to show excellent antioxidant activity. Chlorophylls and their derivatives have also been reported to possess this activity. However, literature is still scarce regarding their antioxidant properties. It is known that the amount of each antioxidant in fruits, vegetables and their derivatives is strongly influenced by numerous factors such as agro-technical processes, environmental conditions, processing factors and storage conditions. Continuous monitoring of antioxidant capacity of plant-based foods through different phases, from cultivation to storage, is needed to maintain or even improve the beneficial properties of food. The goal of this project is to develop several cyclic multi-pulse voltammetric techniques for the characterization of natural antioxidants and to apply them in routine analysis of food quality. Experimental results will be explained by the comparison with the theoretical simulation of responses of various electrode mechanisms of independent and conjugated multiple redox centers.]]></summary_en></project><project>
<id>1459</id><title_hr><![CDATA[Istraživanje utjecaja na okoliš primjene nanomaterijala u pročišćavanju voda]]></title_hr><title_en><![CDATA[Environmental Implications of the Application of Nanomaterials in Water Purification Technologies]]></title_en><user_id>984</user_id><user_firstLast_name>Hrvoje Kušić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2013-11</proposal_call><code>UIP-2013-11-7900</code><acronim><![CDATA[NanoWaP]]></acronim><duration>20.07.2014 - 19.07.2017</duration><status>Završio</status><financ_value>125.949,23 eur</financ_value><scie_area_hr>Tehničke znanosti, Prirodne znanosti, </scie_area_hr><scie_area_en>Technological sciences, Natural sciences, </scie_area_en><scie_field_hr>Kemijsko inženjerstvo, </scie_field_hr><scie_field_en>Chemical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet kemijskog inženjerstva i tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Chemical Engineering and Technology]]></institution_en><team_members_id>1122, 1123, 3191, 3845, 3168, 17765, </team_members_id><team_members_names><![CDATA[Ana Lončarić Božić, Daria Juretić, Dionysios Dionysiou, Urska Lavrencic Stangar, Panaghiotis Karamanis, Marin Kovačić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Water treatment, Advanced oxidation technologies, Photocatalysis, Pharmaceuticals degradation, Nanocomposites, Toxicity]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The water resources globally are facing tremendous pressures due to increased consumption and pollution caused by growing population and industrialization. Thus, the development of advanced treatment technologies is highly required. Technologies using nanomaterials are one of the fast-growing fields creating variety of new commercial nanoparticles. One of the innovative applications of nanomaterials with a great potential involve their usage as water treatment tools. The photocatalytic treatment using nano-TiO2 as a destructive and “zero” waste method for water purification provides a synergy of advanced oxidation technologies and nanomaterials application with a great potential to be commercialized. However, some features of TiO2 photocatalysis, its mechanical and chemical stability, have to be improved to minimize the potential negative implications.The main goal of NanoWaP project is to develop the sustainable photo-AOT with nanocomposite photocatalysts for the purification of water containing pharmaceuticals. In order to overcome the limitations of nano-TiO2 technologies: agglomeration tendency, post-separation, low activation potential under the sunlight, novel nano-TiO2-based composites with iron-exchanged zeolites and SnS2 will be investigated for degradation of pharmaceuticals in water. The efficiency will be evaluated using an innovative integral approach including: (i) pharmaceuticals removal expressed in a terms of common ecological parameters, (ii) energy consumption per decreased concentration of chosen ecological parameter for one order of magnitude, and (iii) the assessment of adverse environmental effects. Besides, the photocatalysts characterization prior and after the treatment would provide an additional insight in its stability which will be also examined through consecutive runs.]]></summary_en></project><project>
<id>1465</id><title_hr><![CDATA[Lokalna proba i mezoskopska dinamika u novim fazama jako koreliranih elektronskih sustava]]></title_hr><title_en><![CDATA[Local Probe and Mesoscopic Dynamics of New Phases in Strongly Correlated Electron Systems]]></title_en><user_id>50</user_id><user_firstLast_name>Miroslav Požek</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-2729</code><acronim><![CDATA[LOMEDY]]></acronim><duration>01.09.2014 - 31.08.2018</duration><status>Završio</status><financ_value>125.427,28 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>3145, 3099, 3159, 3165, 3109, 3116, 17735, 23833, </team_members_id><team_members_names><![CDATA[Antonije Dulčić, Dalibor Paar, Mihael Srđan Grbić, Marko Bosiočić, Damjan Pelc, Tonči Cvitanić, Marija Došlić, Ana Najev, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[nuclear magnetic resonance, microwaves, cuprates, pnictides, frustrated spin systems, charge order]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Investigations of strongly correlated electron systems (SCES) attract an ever-growing scientific community, not only because of high potential for new technological applications, but also as a virtually unfailing source of new basic phenomena and theoretical concepts. The properties of such systems can be described only by taking into account collective phenomena governed by strong and competing interactions, often leading to frustrations. The subtle interplay of interactions is, in turn, a key ingredient for extraordinary complex phase diagrams exhibited by SCES. Even more interesting are regions of instabilities away from stable phases.The way a new phase emerges close to a phase boundary reveals hidden properties of the studied system. It is extremely important to understand how symmetry breaks in the transition itself and identify the space and time-scales relevant for the changes of order parameter within the transition. Sometimes an intermediate state emerges between two stable phases, bringing new physics to light. This project aims to study some of these new, mostly unexplored states that emerge between well explored stable phases in SCES, or as a consequence of some kind of frustration. In order to obtain a complete picture of new states of matter we will combine several advanced experimental methods: nuclear magnetic and quadrupolar resonance (NMR and NQR) as an atomic-scale, local probe, and nonlinear conductivity as a mesoscopic probe of electronic physics. We will be able to systematically study the many phases and transitions in SCES, provide answers to some currently burning questions, and significantly advance our knowledge about them. In particular, we will study charge order in novel superconductors, and spin liquid and spin nematic states in frustrated quantum spin systems.The project will fully employ the new broadband NMR laboratory in Zagreb, strengthen its visibility and international collaborations, and enable finishing of three PhD theses.]]></summary_en></project><project>
<id>1473</id><title_hr><![CDATA[Defolijatori kao invazivni šumski štetnici u uvjetima klimatskih promjena ]]></title_hr><title_en><![CDATA[Defoliators as invasive forest pests in changing climate conditions]]></title_en><user_id>3209</user_id><user_firstLast_name>Milan Pernek</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-7616</code><acronim><![CDATA[DIFPEST]]></acronim><duration>16.06.2014 - 15.06.2017</duration><status>Završio</status><financ_value>52.292,79 eur</financ_value><scie_area_hr>Biotehničke znanosti, Prirodne znanosti, </scie_area_hr><scie_area_en>Biotechnical sciences, Natural sciences, </scie_area_en><scie_field_hr>Šumarstvo, </scie_field_hr><scie_field_en>Forestry, </scie_field_en><institution_hr><![CDATA[Hrvatski šumarski institut]]></institution_hr><institution_en><![CDATA[Croatian Forest Research Institute]]></institution_en><team_members_id>868, 2968, 4683, 6691, 6721, 6774, 6993, 17805, </team_members_id><team_members_names><![CDATA[Dinka Matošević, Nikola Lacković, Andreas Linde, Christa Schafellner, Leellen Solter, George Melika, Christian STAUFFER, Ivan Lukić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[invasive forest pests, climate change, biodiversity, insect pathology, Lymantria dispar, Abraxas pantaria,Cydalima perspectalis]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Climate change, particularly extreme weather events, can directly affect forest pests and the damage they cause by influencing the pests’ development, survival, reproduction and spread and by altering host defences and susceptibility. Basic knowledge of the identity, origin, pathway, and time of introduction of invasive species is essential for assessing the threats. Warming is expected to force species to shift their distributions by expanding into new climatic areas. Several projects have shown that genotypes have increasingly migrated to the north in the last decade, mainly caused by climate change. Records of changes as a result of pest-host-climate change interaction, including possible reasons for changes, are a crucial point of forest monitoring which forms the basis for control strategies and forest management decisions. We will build case studies to represent a specific pest-host-climate change interaction model: native and potentially invasive: i) from one isolated population to other population, (Gypsy Moth); ii) from one climate/geographic region to another (Abraxas pantaria) and non-native potentially invasive in a new climate/geographic region (Cydalima perspectalis). The study presents an extensive research on targeted insect pests in Croatia, taking into account the biology of the pest and host plants and all aspects of the bioecology of the species like genetic constitution and origin, thermal requirements, possible host plants, palatability, influence of antagonists etc.) that influence its spread in a novel environment influenced by climate change and possible serious damage. All the gained data could be used for predictive pest risk analysis models for the researched species, as well as for other native and non-native invasive species that could become a serious threat to Croatian forest ecosystems in changed climate conditions in the near future. ]]></summary_en></project><project>
<id>1478</id><title_hr><![CDATA[GENOMIKA I MOLEKULARNA EPIDEMIOLOGIJA HUMANIH PARAMIKSOVIRUSA U HRVATSKOJ]]></title_hr><title_en><![CDATA[GENOMICS AND MOLECULAR EPIDEMIOLOGY OF HUMAN PARAMYXOVIRUSES IN CROATIA]]></title_en><user_id>936</user_id><user_firstLast_name>DUBRAVKO FORČIĆ</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-6255</code><acronim><![CDATA[ParamyxoCro]]></acronim><duration>01.09.2014 - 31.08.2018</duration><status>Završio</status><financ_value>127.015,73 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu]]></institution_hr><institution_en><![CDATA[University of Zagreb]]></institution_en><team_members_id>2510, 3085, 2521, 4279, 4779, 2562, 3357, 3005, 3622, 17817, 23373, </team_members_id><team_members_names><![CDATA[Maja Šantak, Jelena Ivančić Jelečki, Tanja Košutić Gulija, Krešo Bendelja, Goran Tešović, Sunčanica Ljubin-Sternak, Maja Markušić, Ana  Savić Mlakar, Mladen Jergović, Anamarija Slović, Nataša Bauk, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Paramyxoviruses, molecular evolution, genomics, virus genotype, molecular epidemiology]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The family Paramyxoviridae harbors a broad spectrum of serious virus pathogens that are of importance to human health and global economics. Paramyxoviruses are RNA viruses with a single-stranded negative sense genome. They have been isolated from a wide variety of species, demonstrating a vast host range and great viral genetic diversity. These ubiquitous pathogens are among the most common causatives of respiratory tract infections and are responsible for a high degree of morbidity and mortality worldwide. The biology of RNA viruses is influenced by their high potential of continuous evolution. Because of the error-prone nature of their RNA-dependent RNA polymerases and large population sizes, RNA viruses show high levels of genetic diversity. Mutations can significantly influence virus biological properties and lead to appearance of new strains. The knowledge of viral evolution depends on the amount of genomic data available for analysis.We propose the research of viral genomics of wild type paramyxoviruses currently circulating in Croatia. It is our goal to increase the number of genetically well characterized paramyxoviral wild-type strains. The proposed work will add to knowledge about paramyxoviral ecology, variability and evolutionary capacities. As molecular epidemiologic monitoring of circulating wild type viruses enables analysis of current relations between existing viral genotypes, it is an invaluable part of virus surveillance and control, facilitating the detection of endemic areas, estimations of vaccine efficacies and predications of possible outbreaks.]]></summary_en></project><project>
<id>1479</id><title_hr><![CDATA[Nano-mreže kvantnih točaka u staklima: Od samouređenja do pretvorbe energije i pohrane vodika]]></title_hr><title_en><![CDATA[Nano-networks of Quantum Dots in Glasses: From Self-assembly to Energy Conversion and Hydrogen Storage]]></title_en><user_id>1362</user_id><user_firstLast_name>Maja Buljan</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2013-11</proposal_call><code>UIP-2013-11-2334</code><acronim><![CDATA[NanoDeSign]]></acronim><duration>01.06.2014 - 31.05.2017</duration><status>Završio</status><financ_value>97.349,99 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>2755, 3498, 3526, 3509, 3556, 19015, 17815, 21151, </team_members_id><team_members_names><![CDATA[Ivančica Bogdanović Radović, Marko Karlušić, Tihomir Car, Marko Jerčinović, Nikola Radić, Davor Galonja, Nikolina Nekić, Stefano (Antonio) Mezzasalma, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Quantum dots, Self-assembly, Magnetron sputtering, Quantum dot crystal, Hydrogen storage, Energy conversion, Solar cell, Ion-beam irradiation]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The main goal of the project is to investigate the capabilities of the recently developed materials based on self-assembled quantum dots organized as nano-networks in glass matrices for application in energy-conversion and Hydrogen-storage devices. Two new self-assembly processes of Ge quantum dots in dielectric amorphous matrices and consequently novel material types have been discovered recently by our group.  We have performed intensive investigation of their structural properties since then, and we had found that they appear in many different shapes, internal structures and ordering types. One material can store large amounts of Hydrogen. However, only properties of Ge and SiGe quantum dots have been investigated, while all other materials and their properties are completely unknown. These materials are theoretically very suitable for applications, especially in photo-electric conversion and energy storage, so the investigations of their properties related to the applications are also very important.We intend to form a group which will be excellent in production, characterization and application of these materials. Precisely, we intend to (i) further investigate the observed self-assembly processes and develop new material types with interesting or extraordinary structural properties; (ii) determine the basic optical and electrical properties of these materials and (iii) produce simple devices based on these materials for energy conversion and storage.We expect preparation of new, applicative materials with exceptional properties, observation of unusual effects caused by specific structure, and preparation of efficient thin-film coatings for conversion and storage of Sun energy. These results could be of great relevance for the production of super-efficient energy-converting window glasses, as the method that we use for the preparation (magnetron sputtering deposition), is a standard technique for production of window coatings and low-emissivity glasses.]]></summary_en></project><project>
<id>1483</id><title_hr><![CDATA[Postupci strojnog učenja za dubinsku analizu složenih struktura podataka]]></title_hr><title_en><![CDATA[Machine learning algorithms for insightful analysis of complex data structures]]></title_en><user_id>4140</user_id><user_firstLast_name>Strahil Ristov</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-9623</code><acronim><![CDATA[DescriptiveInduction]]></acronim><duration>16.08.2014 - 15.08.2017</duration><status>Završio</status><financ_value>45.391,20 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>3806, 3548, 3945, 3822, 4312, 4568, 4718, 17767, 1483, </team_members_id><team_members_names><![CDATA[Tomislav Šmuc, Ivan Michieli, Peter Škoda, Branka Medved Rogina, Nino Antulov-Fantulin, Matija Piškorec, Damir Korenčić, Maria Brbic, Dragan Gamberger, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[machine learning, knowledge discovery, structured data, rule learning, FPGA]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[ Induction is a process of knowledge extraction from information contained in data. In our work we will concentrate on descriptive induction whose goal is to construct knowledge that enables human understanding of the data. Included are techniques for construction of user-interpretable models, segmentation of the corpus of examples, and detection of outliers. The methodology is relevant for the computer science fields known as intelligent data analysis, knowledge discovery from data, and data mining. At Rudjer Boskovic Institute we are developing machine learning algorithms for more than 15 years and we have successfully applied them in various domains including chemistry, biology, medicine, social sciences, economics, and manufacturing. With this project we want to extend the existing methodology and to implement novel techniques able to cope with data contained in complex structures. The main topic will be spatio-temporal structures but we will work also with networks of data, relational databases, and data contained in ontologies. Previous experience clearly demonstrates that complete transformation of information contained in structured data into a form that may enter the induction process is not a simple task. Our goal is to develop and implement systematic and general approaches for this conversion. The consequence will be explosion of generated data that must enter into the process of induction. Therefore, the second goal will be implementation of efficient algorithms for descriptive induction. The work includes development of novel algorithms for clustering and outlier detection in sets of unclassified examples and implementation of hardware for fast execution of rule learning algorithms. The third goal is application and evaluation of implemented algorithms in various real-life domains. The success of the complete project will be measured by the quality and usefulness of knowledge obtained in these applications.]]></summary_en></project><project>
<id>1484</id><title_hr><![CDATA[Bioinspirirani materijali - mehanizmi nastajanja i interakcija]]></title_hr><title_en><![CDATA[Bioinspired Materials - Formation Mechanisms and Interactions]]></title_en><user_id>922</user_id><user_firstLast_name>Damir Kralj</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-5055</code><acronim><![CDATA[Bio-Mat-Form]]></acronim><duration>01.10.2014 - 31.01.2019</duration><status>Završio</status><financ_value>118.587,83 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>224, 339, 340, 336, 3922, 3932, 220, 425, 406, 297, 4209, 404, 17878, </team_members_id><team_members_names><![CDATA[Maja Dutour Sikirić, Darija Jurašin, Vlasta Tomašić, Tea Mihelj, Andreja Gajović, Milivoj Plodinec, Jasminka Kontrec, Branka Njegić Džakula, Marko Ukrainczyk, Iva Buljan, Nadica Maltar Strmečki, Vida Čadež, Lara Štajner, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Biomineralization, Calcium Phosphates, Calcium Carbonates, Precipitation, Model organic molecules]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Prosperity of modern society at large extent relies on the design of new and advanced materials. Many classes of organic, inorganic or hybrid materials are produced by process of precipitation (crystallization) in which the size, morphology, chemical and structural composition could be tuned by the strict control of formation conditions. Process by which living organisms produce hard tissues is known as biomineralization and such tissues are, actually, the organic-inorganic composites. In comparison to their geological analogues, biominerals have the superior mechanical and chemical properties that are a consequence of just a minor presence of extracellular matrix proteins or polysaccharides, as well as of the specific confined environment in which the process occur. In addition, such materials are produced from aqueous systems, chemically neutral precursors, at low temperature and pressure, thus inspiring the scientists investigating the biomimetic syntheses routes for design of functional materials for advanced application.In order to contribute to the understanding of basic interactions between the mineral phases and complex macromolecules, underlying biomineralization, we propose the investigations in which the representative inorganic salts (calcium carbonates & phosphates) will be precipitated in a presence of simple and representative organic molecules (acidic and hydrogen bonding amino acids and custom-designed small peptides) while the complexity of systems will be systematic increased by confining the precipitation in polysaccharide hydrogel or synthetic vesicular microenvironment. Particular attention will be paid on a role of the amorphous and other precursor phases on formation of stable modifications relevant for biomineralization. Besides the precipitation kinetic analyses, the advanced characterization techniques (HR-TEM, EPR, confocal microscopy) will be applied in order to reveal the mechanisms of organic molecules – mineral surface interactions.]]></summary_en></project><project>
<id>1487</id><title_hr><![CDATA[Procjena ponašanja konstrukcija u graničnim uvjetima rada]]></title_hr><title_en><![CDATA[Assessment of structural  behaviour in limit state operating conditions]]></title_en><user_id>3256</user_id><user_firstLast_name>Josip Brnić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-6876</code><acronim><![CDATA[STRUBECON]]></acronim><duration>21.07.2014 - 20.07.2018</duration><status>Završio</status><financ_value>128.727,85 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, </scie_field_hr><scie_field_en>Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Tehnički fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Engineering]]></institution_en><team_members_id>3309, 3419, 3329, 3323, 3325, 3328, 3332, 3330, 3318, 17760, </team_members_id><team_members_names><![CDATA[Goran Turkalj, Marko Čanađija, Domagoj Lanc, Marino Brčić, Goran Vukelić, Igor Pešić, Sanjin Kršćanski, Neven Munjas, Edin Merdanović, Damjan Banić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[structures, material properties, experimental investigations, numerical investigations, limit state, assessment of structural behaviour]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Structures are designed according to their purpose taking into account all relevant service life requirements, which are usually related to a factor of safety, material properties, service life conditions and of course service life prediction. Structure may be sometimes exposed to unexpected conditions, let say adverse or hazard conditions. These conditions may cause failures making structure incapable to perform the function for which it has been designed. The task is to make an assessment of the structure behaviour at mentioned conditions and decide if the structure is capable for further operation. This means the assessment should provide an answer if the structure has sustained irreparable damage. Therefore, the main objective is to provide an assessment of structure behaviour, by comparing of the parameters like stress, strain, crack occurring, etc., caused by certain load level and temperature at this unexpected limit state with those allowed by material properties. To assess structural behaviour in operation at limit state, the following research sub-objectives should be accomplished: testing of material properties for the different environmental conditions; definition of impact energy as well as the determination of the crack driving force and life assessment of structural elements; evaluation of the semi-rigid structural joints/connections behaviour; development of a numerical algorithm for optimization of semi-rigid framed structures; creep buckling simulations of composite beam-type structures; proper constitutive modelling at limit operating conditions (i.e. plasticity, damage, thermomechanical coupling); application of new materials to be used at limit state – nanocomposites. Targeted structures are single and multi storey steel buildings, rigs, high-power electrical transmission towers, ship structures, etc.]]></summary_en></project><project>
<id>1493</id><title_hr><![CDATA[Višeskalno numeričko modeliranje deformiranja materijala od makro do nanorazine]]></title_hr><title_en><![CDATA[Multiscale Numerical Modeling of Material Deformation Responses from Macro- to Nanolevel]]></title_en><user_id>927</user_id><user_firstLast_name>Jurica Sorić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-2516</code><acronim><![CDATA[MNumMacroNano]]></acronim><duration>15.07.2014 - 14.07.2018</duration><status>Završio</status><financ_value>127.376,63 eur</financ_value><scie_area_hr>Tehničke znanosti, Biotehničke znanosti, Prirodne znanosti, </scie_area_hr><scie_area_en>Technological sciences, Biotechnical sciences, Natural sciences, </scie_area_en><scie_field_hr>Temeljne tehničke znanosti, </scie_field_hr><scie_field_en>Basic engineering sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>1010, 1039, 1028, 2803, 1012, 3311, 285, 17578, 17579, 21241, 21256, 21254, </team_members_id><team_members_names><![CDATA[Igor Karšaj, Ivica Skozrit, Boris Jalušić, Tomislav Lesičar, Lana Virag, Zdenko Tonković, Robert Pezer, Filip Putar, Ivan Trapić, Karlo Seleš, Christian Weißenfels, Joško Frančeski, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Engineering materials, bilogical tissues, multiscale modeling, finite element  method, meshless method, damage modeling, molecular dynamics]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Many engineering materials as well as biological tissues have a heterogeneous structure particularly when they are observed at microlevel. In order to assess structural integrity as well as to predict structural lifetime, an analysis at microlevel is required. In recent years, a special attention has been directed to the investigation of relations between macroscopic properties of materials and their microstructure as well as to perform a link to atomistic scale. Since classical continuum mechanics cannot consider structural effects in the material at the micro- and nanolevel, multiscale techniques are developed that model material deformation responses at multiple levels using appropriate numerical procedures. Deformation responses of arteries will be considered by using multiscale computational strategy too. A special attention will be directed toward the mathematical modeling of arterial growth and remodeling, which could help physicians to track certain cardiovascular diseases and predict their development. For modeling of engineering materials, a new micro-macro numerical procedure based on the second-order computational homogenization approach employing nonlocal continuum theory will be proposed. Both finite element and meshless spatial discretization will be applied. The damage evaluation at the microlevel which may lead to macroscopic fracture will be modeled. Here the damage evaluation law based on the computational averaging procedure will be used and the modeling at atomistic scale will be performed in the very narrow domain of localization. In the atomistic modeling using molecular dynamics, a special attention will be directed to the coupling of atomistic domain with the discretized continuum domain. An approach inspired by the quasicontinuum and bridging domain will be proposed. All results of the research will be tested by the modeling deformation responses of realistic materials.]]></summary_en></project><project>
<id>1497</id><title_hr><![CDATA[Djelovanje progesterona u reproduktivnim i ne-reproduktivnim tkivima]]></title_hr><title_en><![CDATA[Progesterone action in reproductive and non-reproductive tissues]]></title_en><user_id>1286</user_id><user_firstLast_name>Biserka Mulac-Jeričević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-3432</code><acronim><![CDATA[reproduction2013]]></acronim><duration>01.09.2014 - 30.11.2018</duration><status>Završio</status><financ_value>132.191,92 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Javno zdravstvo i zdravstvena zaštita, </scie_field_hr><scie_field_en>Public health and health services, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Medicine]]></institution_en><team_members_id>3456, 3448, 3361, 3467, 5756, 4733, 5775, </team_members_id><team_members_names><![CDATA[Sandra Šućurović, Zdravko Jotanović, Jagoda Ravlić-Gulan, Gordan Gulan, Jan Brosens, Neda Smiljan Severinski, Hrvoje Jakovac, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Progesterone, progesterone receptors, uterus, bone, physiology, pathophysiology, animal model, human]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Progesterone (P) is an indispensable regulator of female reproductive function, but also has an important role in non-reproductive tissues. Aberrant P signaling has been associated with reproductive conditions, cancer, metabolic disorders, cardiovascular defects, and neurological defects. In humans and mice the physiological effects of P are mediated by two intracellular receptors, termed PR-A and PR-B, expressed in subset of cells in target tissues. PR-A and PR-B isoforms are transcribed from a single gene by alternative promoter usage. PR-A (94 kD) isoform differ from PR-B (120 kD) by lacking 164 amino acids at the N terminus . Analyses to date have shown that PR-A and PR-B mediate mostly distinct but partially overlapping reproductive tissue selective physiological responses to P. The overall objective of this research is to establish the selective physiological roles of each of the individual PR isoforms in their natural physiological context. For this research we will use a genetically modified mouse in which gene targeting was used to knockout expression of either the PR-A or PR-B isoform in mice. The specific aims of this application are as follows: 1. To examine the isoform-selective molecular mechanisms by which PR-A and PR-B differentially regulate uterine epithelial proliferation, uterine receptivity and stromal decidualization. 2. To examine the selective contributions of the PR-A and PR-B isoforms to the P dependent immunomodulatory activity during early pregnancy. 3. To identify progesterone-regulated genes in musculoskeletal tissue using a genetically altered mouse models lacking progesterone receptors. 4. To determine whether differential signaling pathways of PR isoforms are conserved from rodent to human. It is expected that this research will contribute to understanding the molecular mechanisms of P in reproductive tissues and musculoskeletal and could lead to new strategies for disease prevention and treatment.]]></summary_en></project><project>
<id>1503</id><title_hr><![CDATA[Genetika i fiziologija tolerancije na višestruki stres kod kukuruza]]></title_hr><title_en><![CDATA[Genetics and physiology of multiple stress tolerance in maize]]></title_en><user_id>3305</user_id><user_firstLast_name>Domagoj Šimić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-5707</code><acronim><![CDATA[MUST-MAIZE]]></acronim><duration>16.06.2014 - 15.06.2018</duration><status>Završio</status><financ_value>107.505,47 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Poljoprivredni institut Osijek]]></institution_hr><institution_en><![CDATA[Agricultural Institute Osijek]]></institution_en><team_members_id>4241, 4812, 5221, 5133, 3283, 6391, 4899, 6193, 4907, 3281, 2824, 6447, 17788, </team_members_id><team_members_names><![CDATA[Mario Franić, Antun Jambrović, Tatjana Ledenčan, Luka Andrić, Maja Mazur, Vera  Cesar, Josip B rkić, Lidija Begović, Zvonimir Zdunić, Andrija Brkić, Jasenka Antunović, Ivan Brkić, Vlatko Galić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[drought, diabrotica, plant density, cadmium excess, genomic selection]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Plant responses to different stresses are highly complex and involve changes at the genetic and physiological levels. Maize as a major crop worldwide is essential for industry and is cultivated mostly in rain-fed cropping systems where changes in climate or diminishing water supply take place. Grain yield, the most important trait in maize as a composite trait is influenced by many stress-related traits. The main goal of this project is to elucidate and integrate common genetic and physiological mechanisms underlying the multiple-stress tolerance in maize. The specific aims are to detect genetic and physiological factors responsible for plant response to high plant density, drought, Diabrotica and Fusarium attacks as well as cadmium excess in soil in testcrosses of two maize populations (reference IBM population and a doubled haploid population) and their respective parents. By investigating root and leaf characteristics including chlorophyll fluorescence and other stress parameters as reliable indicators of stress in four-year field and pot experiments conducted in Croatia and Turkey, DNA marker-assisted selection and genomic selection could accelerate maize breeding for yield, abiotic and biotic stress tolerance. A multidisciplinary approach, which ties together breeding, physiology and molecular genetics, can bring a synergistic understanding to the response of maize to multiple stresses.]]></summary_en></project><project>
<id>1513</id><title_hr><![CDATA[Povijesne perspektive transnacionalne prakse i međukulturnog dijaloga u Austro-Ugarskoj monarhiji]]></title_hr><title_en><![CDATA[Historical Perspectives on Transnationalism and Intercultural Dialogue in the  Austro-Hungarian Empire]]></title_en><user_id>1018</user_id><user_firstLast_name>Anita Sujoldžić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-3914</code><acronim><![CDATA[TIDA]]></acronim><duration>01.09.2014 - 31.08.2018</duration><status>Završio</status><financ_value>73.608,07 eur</financ_value><scie_area_hr>Humanističke znanosti, Društvene znanosti, </scie_area_hr><scie_area_en>Humanities, Social sciences, </scie_area_en><scie_field_hr>Etnologija i antropologija, </scie_field_hr><scie_field_en>Ethnology and anthropology, </scie_field_en><institution_hr><![CDATA[Institut za antropologiju]]></institution_hr><institution_en><![CDATA[Institute for Anthropological Research]]></institution_en><team_members_id>2965, 3447, 1284, 4784, 1524, 3749, 2753, 20152, 3395, </team_members_id><team_members_names><![CDATA[Zrinjka Glovacki-Bernardi, Gottsmann Andreas, Olga Orlić, Stefan Wedrac, Mirna Jernej Pulić, Anja Ivekovic Martinis, Marina Rončević, Duga Mavrinac, Krešimir Sučević-Međeral, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[multilingualism, transnational, intercultural, communication, hybridity, legacy]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[This interdisciplinary project aims to provide a new way of learning from the past about strategies used in the South-Eastern part of the Austro-Hungarian Empire to overcome social tensions as a potential legacy of intercultural dialogue in the present European context. It will explore how in  the multilingual imperial space of intensive cultural exchange and economic mobility the interethnic and social tensions were shaped by (trans)-intercultural communication and practices, both from above and from below. It focuses on accounts of plural belongings and hybrid identities that are geographically grounded, socio-economically situated and embedded in cultural and linguistic practices manifested by multilingualism  and intercultural competence of social scripts and behaviour.The project will cover spatially and regionally confined patterns of interaction in the Croatian part of Istria, and the cities of Pula and Zadar under direct Habsburg influence and in the cities of Rijeka and Zagreb, politically bound to the Hungarian part of the Empire during the period 1870-1918. The main strains of research will focus on uncovering discourses produced through three social spaces, those of institutions (administration and education), associations (cultural, sport), and those visible in everyday life, through consumption practices and tourism. The analyses will encompass social practices in different domains of life, symbolic system (focusing on language) and the use of artifacts, or material life. The specific objective is to provide a contrastive reading of Austro-German, Italian and Slavic sources illuminating both the established discourses of knowledge production, emanating from imperial centres of Vienna and Budapest, and the counter-discourses, and their reception by common people in the periphery.]]></summary_en></project><project>
<id>1516</id><title_hr><![CDATA[Pravni status i stvarni položaj osoba s duševnim smentnjama - interdisciplinarni pristup i europske perspektive]]></title_hr><title_en><![CDATA[Legal Status and Real Position of People with Mental Difficulties – Interdisciplinary Approach and European Perspectives]]></title_en><user_id>597</user_id><user_firstLast_name>Velinka Grozdanić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-2287</code><acronim><![CDATA[LSRPPMDIAEP]]></acronim><duration>01.03.2015 - 28.02.2018</duration><status>Završio</status><financ_value>19.389,77 eur</financ_value><scie_area_hr>Društvene znanosti, Biomedicina i zdravstvo, </scie_area_hr><scie_area_en>Social sciences, Biomedicine and health sciences, </scie_area_en><scie_field_hr>Pravo, </scie_field_hr><scie_field_en>Law, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Pravni fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Law]]></institution_en><team_members_id>3337, 2985, 7306, 2901, 4639, 2875, 3315, 19033, </team_members_id><team_members_names><![CDATA[Miroslav Goreta, Vesna  Šendula Jengić, Zoran Kanduč, Kristijan  Grđan, Marissabell Škorić, Dalida Rittossa, Igor Martinović, Dražen Tripalo, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[people with mental disorders, legal status, actual position, interdisciplinary perspective, European standards  ]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[In last two years the European Court for Human Rights assessed three major cases involving rights of persons with mental disorders in the Republic of Croatia (Đorđević v. Croatia, M.S. v. Croatia and A.K. and L. v. Croatia). The Court concluded that current legal regulations and practice governing the prevention of violence against mentally disabled persons, their power to instigate criminal proceedings without explicit guardian&#39;s consent and divestment of parental rights have violated the Article 3 and 8 of the Convention of Human Rights and Fundamental Freedoms. Court decisions present a clear warning that rights of people with mental difficulties have not been adequately protected in Croatia and that there is a need for substantial reform of the laws regulating their legal status. Bearing this in mind, the Project is designed to critically analyse current legal regulations in the light of already accepted high international standards and to conduct empirical research at four county courts with the widest jurisdiction in order to evaluate whether the regulations are adequately applied in practice. Analytical and empirical results will be used as a valid basis to create a new Bill on Protection of Persons with Mental Difficulties as the main legal instrument to regulating the legal status of this especially vulnerable group. In order to facilitate application of the new Law in practice and to make a concrete impact on real position of people with mental health issues, the project will seek to organise seminars, round table discussions and workshops for mental health lawyers and psychiatrists. By its in-depth research approach in interdisciplinary settings, the ultimate Project goal is to improve and promote rights of people with mental disability and increase their empowerment, enabling them to enjoy full citizenship on an equal basis with other members of Croatian society.]]></summary_en></project><project>
<id>1518</id><title_hr><![CDATA[Standardizacija i primjenjena istraživanja kvartarnih sedimenata Hrvatske]]></title_hr><title_en><![CDATA[STANDARDISATION AND APPLYED INVESTIGATION OF QUATERNARY SEDIMENTS IN CROATIA]]></title_en><user_id>3320</user_id><user_firstLast_name>Lidija Galović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2013-11</proposal_call><code>UIP-2013-11-4425</code><acronim><![CDATA[SAPIQ]]></acronim><duration>01.09.2014 - 31.12.2017</duration><status>Završio</status><financ_value>129.811,14 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Geologija, </scie_field_hr><scie_field_en>Geology, </scie_field_en><institution_hr><![CDATA[Hrvatski geološki institut]]></institution_hr><institution_en><![CDATA[Croatian Geological Survey]]></institution_en><team_members_id>3963, 4030, 4262, 3950, 3511, 3956, 165, 4536, 7107, 20279, 20272, 20205, </team_members_id><team_members_names><![CDATA[Lara Wacha, Adriano Banak, Anita Grizelj, Hrvoje Posilović, Koraljka Bakrač, Danijel Ivanišević, Jadranka Mauch Lenardić, Manfred Frechen, Petar Stejic, Rodoljub Gajić, Mihajlo Pandurov, MARSCHE INGEBORG Soulie-Marsche , ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Quaternary, litostratigraphical unites, Croatia, spatial distribution, climate proxies]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Quaternary sediments in Croatia cover about 40% of the surface and have hence an important role in the economy of the country. Achieved models and tools for investigation enable wider application of results in economy. Furthermore, Quaternary deposits are direct results of ancient climatic conditions and hence understanding them can help interpreting and predicting actual events. The goal of this Installation Research Project is to establish a group of researchers in the Croatian Geological Survey (CGS), Department of Geology, to additionally equip and train them, so they could standardise and carry out their research of Quaternary sediments of Croatia applying new analytical techniques and new scientific findings. Those new compositional data will enable correlating our results with the EU, especially for the middle and south Europe. In this project we would like to deal with Quaternary sediments on the both regions: Pannonian and Dinaric. During the first year we plan to get know new equipment, methodology and to investigate all the different types of Quaternary sediments in Croatia. In the second and third year plan is to scrutinize the sediments in selected area in the each region (Pannonian and Dinaric).The strategic importance of Quaternary sediments for Croatia is based partly on the agricultural utilization of the Holocene soils developed on these deposits and partly as a collector of drinking water, reflecting to the whole biosphere. Furthermore, the hydrogeological properties of separate horizons of Quaternary sediments are different, so, insight in the structures of sediment layers could lead to finding new water resources.]]></summary_en></project><project>
<id>1526</id><title_hr><![CDATA[Razvoj višenamjenskog sustava upravljanja zemljištem]]></title_hr><title_en><![CDATA[Development of Multipurpose Land Administration System]]></title_en><user_id>426</user_id><user_firstLast_name>Miodrag Roić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-7714</code><acronim><![CDATA[DEMLAS]]></acronim><duration>01.09.2014 - 31.08.2018</duration><status>Završio</status><financ_value>122.469,97 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Geodezija, </scie_field_hr><scie_field_en>Geodesy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Geodetski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Geodesy]]></institution_en><team_members_id>5698, 3172, 3563, 3628, 3704, 3304, 3205, 837, 3180, 3060, 4353, 3245, 3065, 3889, 4200, 4197, 3758, 3356, 3629, 3725, 4349, 4189, 5610, 6782, 21294, 21295, </team_members_id><team_members_names><![CDATA[Siniša Mastelić Ivić, Vlado Cetl, Rinaldo Paar, Dražen Tutić, Hrvoje Matijević, Ante Marendić, Loris Redovniković, Hrvoje Tomić, Mario Mađer, Baldo Stančić, Iva Ališić, Goran Jurakić, Saša Vranić, Boris Blagonić, Irena Benasić, Veljko Flego, Blaženka Mičević, Nikola Vučić, Darko Šiško, Jelena Jurišić, Tiana Pribanić, Marijan Ratkajec, Frančesko Duboković, Miroslav Kuburić, Dragan Divjak, Igor Grgac, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Land Administration System, Land Registers, Land Management, Sustainable Development, Geoinformation]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The primary purpose of a land administration system (LAS) is the registration of legal or other formal relations of persons to land. Besides its primary purpose, land administration system can and should also serve as a basis for land management. Different to the land administration, land management is a set of processes ensuring that the land is used in an efficient and sustainable manner. Unfortunately, land administration systems are rarely able to fulfill such additional requirements, even in the developed countries.This project aims at finding what needs to be done in order to transform a traditional land administration system into a modern multipurpose land administration system (MLAS), which can efficiently support land management. Our hypothesis says that such a transformation can be done by improving two aspects of a LAS, its efficiency and its usability.Under efficiency we consider the ability of a LAS to update its data quickly whilst ensuring the consistency and correctness thereof. Within the project we will investigate options for outsourcing the preparation of transactions to private sector and the possibilities to more efficiently collect field data within the improved process of updating LAS data.Even more important that its efficiency, is the usability of a LAS. This is the second aspect that we try to improve within the project. Besides the mere registration of the land, MLAS must be able to efficiently support processes of land valuation, urban planning and various rearrangements aiming to increase agricultural productivity of the land. Within the project we will investigate which additional data needs to be collected, processed and stored within the LAS in order to enable efficient support to land management processes.As a starting point for the research we use our previous research closely related to the topics of land administration and land management, and the Land Administration Domain Model (LADM), which recently became the ISO standard.]]></summary_en></project><project>
<id>1528</id><title_hr><![CDATA[Repozitorij metafora hrvatskoga jezika]]></title_hr><title_en><![CDATA[Croatian Metaphor Repository]]></title_en><user_id>3388</user_id><user_firstLast_name>Kristina Štrkalj Despot</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2013-11</proposal_call><code>UIP-2013-11-3624</code><acronim><![CDATA[Meta4Cro]]></acronim><duration>01.09.2014 - 31.08.2017</duration><status>Završio</status><financ_value>74.324,77 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filologija, </scie_field_hr><scie_field_en>Philology, </scie_field_en><institution_hr><![CDATA[Institut za hrvatski jezik]]></institution_hr><institution_en><![CDATA[Institute of Croatian Language]]></institution_en><team_members_id>4388, 4516, 2966, 4665, 5556, </team_members_id><team_members_names><![CDATA[Benedikt Perak, Mirjana Tonković, Bruno Nahod, Mario Essert, Mario Brdar, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[conceptual metaphor, image schemas, frames, metonymy, metaphor in natural language processing and artificial intelligence]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The Croatian Metaphor Repository project will involve: theoretical research of conceptual metaphor, metonymy, image schemas and frames in the Croatian language from a synchronic and diachronic perspective; computational linguistic research on metaphor in natural language processing and artificial intelligence involving developing tools for semi-automatic metaphor detection and semi-automatic extraction of linguistic metaphors; psychological experiments to further explain the nature of the links between concept meaning and perception as manifested through primary metaphors. The applied goal of the project is to create a metaphorical language database ? the Croatian Metaphor Repository. The database will be available on the Internet. It will include the following levels: conceptual metaphors, linguistic metaphors, image schemas, cogs and frames. Metaphors will be divided by type (primary, complex and entailed metaphors), by level (general, specific), and by family (Event Structure Metaphors, Mind Metaphors, Morality Metaphors, Scalar Metaphors, Time Metaphors, Emotion Metaphors, Economics Metaphors, Governance Metaphors, Cascade Metaphors, Well-being Metaphors etc.). The theoretical background for the linguistic analysis of conceptual metaphors is the Neural Theory of Language and Thought and the Neural Theory of Metaphor. Formal annotation tools are taken from embodied construction grammar. Both theoretical research and the creation of the repository will significantly advance Croatian cognitive and computational linguistics, artificial intelligence studies and the research of language and learning processes. The database will allow for generalizations and will become a very useful tool for cross-linguistic and cross-cultural research of metaphor and thought leading to further development of the theory and the field and to understanding how people learn, understand, and use language. The project has significant potential for further international development.]]></summary_en></project><project>
<id>1531</id><title_hr><![CDATA[Kodovi i s njima povezane kombinatoričke strukture]]></title_hr><title_en><![CDATA[Codes and Related Combinatorial Structures]]></title_en><user_id>885</user_id><user_firstLast_name>Dean Crnković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-1637</code><acronim><![CDATA[CoCoS]]></acronim><duration>01.07.2014 - 30.06.2018</duration><status>Završio</status><financ_value>114.972,04 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Fakultet za matematiku]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Mathematics]]></institution_en><team_members_id>919, 907, 5381, 5935, 4515, 4484, 4992, 841, 1089, 3161, 3906, 3468, 3226, 5384, 17780, 20561, </team_members_id><team_members_names><![CDATA[Sanja Rukavina, Vedrana Mikulić Crnković, Mario Osvin Pavčević, Vedran Krčadinac, Andrea Švob, Anamari Nakić, Kristijan Tabak, Loredana Simčić, Doris Dumičić, Marija Maksimović, Ana Grbac, Nina Mostarac, Marina Šimac, Sanja Vranić, Renata Vlahović, Ronan Egan, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[code, network coding, t-design, q-ary design, graph, strongly regular graph, finite group]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The project will deal with construction of codes and combinatorial structures, such as combinatorial designs, designs over finite fields (q-ary designs), difference sets and various types of graphs, for example strongly regular graphs and divisible design graphs. Beside linear codes over finite fields and finite rings, we will also investigate quantum codes and network codes. In fact, the links and connections between codes and combinatorial structures are the main focus and emphasis of the proposed project. For constructions of the combinatorial structures and codes we will mainly use algebraic, geometric and enumerative techniques, as well as computational methods. When dealing with combinatorial structures, these include in particular constructions from finite groups and constructions using orbit matrices. The very general Kramer-Mesner method will be implemented and combined with other methods like that of tactical decompositions. Codes will be constructed directly from the obtained combinatorial structures, and vice versa. Our research in scope of this project will also include constructions of Hadamard matrices and related designs and codes. All gotten structures will be analyzed in terms of their automorphism groups and other structural (geometric, algebraic) properties. Obtained codes, designs and graphs will be compared with the previously known structures. As a result of the proposed research, we expect constructions of codes with good properties, possibly better than the presently known codes, and constructions and classifications of various combinatorial structures.]]></summary_en></project><project>
<id>1535</id><title_hr><![CDATA[Upravljanje vodom i toplinom i trajnost membranskih gorivnih članaka]]></title_hr><title_en><![CDATA[Water and Heat Management and Durability of PEM Fuel Cells]]></title_en><user_id>1118</user_id><user_firstLast_name>Frano Barbir</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-8700</code><acronim><![CDATA[PEMFUELCELL]]></acronim><duration>01.01.2015 - 30.06.2018</duration><status>Završio</status><financ_value>106.427,77 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, </scie_field_hr><scie_field_en>Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Fakultet elektrotehnike, strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Electrical Engineering, Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>3668, 4330, 3698, 4347, 4058, 97, 4479, 17740, 18920, </team_members_id><team_members_names><![CDATA[Ivan Tolj, Dario Bezmalinović, Gojmir Radica, Gojko Magazinović, Jagoda Radošević, Ante Bilušić, Paško Županović, Ivan Pivac, Željko Penga, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[PEM fuel cell,  temperature control, humidity of reactant gases, durability stressors, decay mechanisms]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The subject of the proposed research and development are the fuel cells – devices for direct electrochemical conversion of fuel (usually hydrogen) into electricity, with many potential applications, from propulsion of vehicles to mobile and stationary power generation at different scales (from mW to MW). This project will investigate a possibility to design and operate a Polymer Electrolyte Membrane (PEM) fuel cell with ambient air without external humidification using water and heat produced inside the fuel cell. This may be accomplished with adequate temperature distribution along the cathode channel, which would require a specific design of the fuel cell in terms of spatially variable heat transfer rates, and corresponding control of the cooling subsystem. In order to determine whether the proposed concept would result in longer life of fuel cell, some basic understanding of causes of fuel cell degradation is needed, particularly related to water and heat management. Particularly, it is proposed to investigate heat transfer in nano-structured catalyst layer because inadequate heat removal from the electrochemical reaction sites may be one of the causes for fuel cell degradation. Other stressors will be studied as well, and procedures for accelerated durability testing will be established, in order to confirm that the proposed concept of  water and heat management is beneficial to fuel cell durability.The proposed research is expected to improve understanding of water and heat transfer in PEM fuel cell, including the effects that dry conditions and inadequate heat removal from the catalyst sites may have on fuel cell durability. This novel concept of variable temperature along the cathode channel would result in simplification of the fuel cell support system by eliminating the devices needed for external humidification, without affecting fuel cell performance and durability in various applications.]]></summary_en></project><project>
<id>1540</id><title_hr><![CDATA[Hrvatska i Srednja Europa: umjetnost i politika u razdoblju moderne (1780. - 1945.)]]></title_hr><title_en><![CDATA[Croatia and Central Europe: Art and Politics in the Late Modern Period (1780-1945)]]></title_en><user_id>3499</user_id><user_firstLast_name>Dragan Damjanović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2013-11</proposal_call><code>UIP-2013-11-4153</code><acronim><![CDATA[CroCE-ArtPolitics]]></acronim><duration>15.06.2014 - 14.06.2017</duration><status>Završio</status><financ_value>74.590,22 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Povijest umjetnosti, </scie_field_hr><scie_field_en>Art history, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>4143, 4151, 4195, 4206, 4237, 4446, 4475, 4459, 4416, 4794, 4554, </team_members_id><team_members_names><![CDATA[Željka Miklošević, Nadežda Čačinovič, Zvonko Maković, Sandi Bulimbašić, Daniel Zec, Lovorka Magaš Bilandžić, Sanja  Zadro, Iskra Iveljić, Silvija Lučevnjak, Frano Dulibić, Jasminka Najcer Sabljak, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Croatia, Central Europe, 19th Century Art, 20th Century Art, Modernism, Sociopolitical Context, Art Discourses, Visual Communication, Popular Culture]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The main aim of the project Croatia and Central Europe: Art and Politics in the Late Modern Period (1780-1945), is to get a comprehensive insight on the basis of fundamental research into relationships between art and political regimes seen from various perspectives and based on different discourses (governmental, social, economic, religious, gender, ethnic and the like) in the given area which has a common political and sociocultural background. The project spans the period from the 1780s, which was marked by great changes in the Hapsburg Monarchy during the reign of Joseph II, to the end of the Second World War when political circumstances brought an end to the integrity of Central Europe. The project has been conceived as a broad-based research of fine and applied arts (painting, sculpture, architecture, graphic arts, photography, comics, cartoons, etc.) through multidisciplinary and interdisciplinary approaches using methods pertaining to humanities and social sciences. Research will comprise topics relating to (mis)use of art for or against political regimes, artistic heritage of marginalized groups, the concept of unwanted heritage and institutional construction of art discourses and their reception. Understanding sociopolitical background can contribute to greater understanding of heritage-based conflicts, while indications of the transnational nature of Central European art can encourage its protection and ensure its sustainability. The research team, headed by an assistant professor from the Faculty of Humanities and Social Sciences, University of Zagreb, consists of academic researchers, doctoral candidates, and professionals from museums and monument protection institutes. Expected results and outcomes of the project include publications on the given topics, a more profound scientific knowledge about art developments within sociopolitical contexts and future collaboration with foreign researchers.]]></summary_en></project><project>
<id>1543</id><title_hr><![CDATA[Utjecaj okolišnog stresa na pojavnost i međudjelovanje biološki važnih organskih molekula i mikronutrijenata u morskom ekosustavu]]></title_hr><title_en><![CDATA[Appearance and interaction of biologically important organic molecules and micronutrient metals in marine ecosystem under environmental stress]]></title_en><user_id>81</user_id><user_firstLast_name>Blaženka Gašparović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-8607</code><acronim><![CDATA[AMBIOMERES]]></acronim><duration>01.10.2014 - 31.01.2019</duration><status>Završio</status><financ_value>110.292,65 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>101, 75, 120, 84, 362, 106, 691, 85, 17849, </team_members_id><team_members_names><![CDATA[Marina  Mlakar, Marta Plavšić, Vlado Cuculić, Sanja Frka Milosavljević, Snježana Kazazić, Slađana Strmečki Kos, Petra Vukosav, Abra Penezić, Tihana Sesar, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[organic matter, lipids, acidic polysaccharides, micronutrient metals, oligotrophy, eutrophy, monocultures, field work]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Recently documented oligotrophication of the Adriatic Sea caused by global changes opened questions how this reflects on the quality and quantity of organic matter (OM) produced by the phytoplankton and on the consequent influence on the micronutrient metals availability and cycling. Within the project, a progressive (model and in-situ) approach will be accomplished to reveal crucial alterations in the marine ecosystem. Initial investigations will imply model experiments on the interaction of selected OM (polysaccharides, lipids, polymeric organic matter containing N catalytic atoms) with micronutrient metals (Fe, Co, Cu, Zn and Cd). Additionally, phytoplankton monoculture incubation under various growth conditions (nutrient concentrations and temperature variations) will be included in order to comprehend multiple impacts on the phytoplankton OM production and micronutrients metals distribution. Model experiments will be followed by in-situ investigations at the selected oligotrophic and eutrophic areas of the Adriatic Sea. This will give holistic informations on the natural marine biochemical cycles and linkage between OM and micronutrient metals. In-situ investigations will be focused on the seasonal variations of the OM and micronutrient appearance and concentrations in combination with physico-chemical parameters (temperature, salinity, pH, O2), and dissolved and particulate organic carbon content, surface-active organic substances and macronutrients (PO4, NO3, NO2, NH4). These investigations will be assessed by intercomparable and multimethodological approaches using various chromatographic to electrochemical techniques. Finally, taking into account all obtained results an important part of the natural marine ecosystem processes will be characterized in the prospective of climate changes.]]></summary_en></project><project>
<id>1551</id><title_hr><![CDATA[Što se zbiva u sjevernom Jadranu? - Klimatske promjene, acidifikacija, bioraznolokost, eutrofikacija. - Nove tehnologije]]></title_hr><title_en><![CDATA[What Works Within northern Adriatic? – Climatic changes, Acidification, Biodiversity, Eutrophication. - New Enhanced Technology]]></title_en><user_id>3596</user_id><user_firstLast_name>Robert Precali</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-8541</code><acronim><![CDATA[www.NA-CABE.net]]></acronim><duration>01.10.2014 - 30.09.2018</duration><status>Prekinut</status><financ_value>0,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>429, 318, 465, 467, 468, 451, 473, 4424, 3992, </team_members_id><team_members_names><![CDATA[Romina Kraus, Tina Šilović, Ingrid Ivančić, Tamara Đakovac, Nastenjka Supić, Jelena Godrijan, Paolo Paliaga, Daniela Maric Pfannkuchen, Jakica Njire, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[northern Adriatic, climatic changes, acidification, biodiversity, eutrophication]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The northern Adriatic (NA) seems to be strongly influenced by the anthropogenic drivers - climatic changes, acidification and eutrophication. Its semi-enclosed nature, characterised by smaller inertia - due to the relative short residence time of its water masses, makes it highly reactive to the external forcing, in particular to the variations of the water, energy and matter fluxes at the interfaces. The NA, identified as a Mediterranean&#39;s climatic change „hotspot“, is expected to withstand environmental impacts that are considerably greater than in many other places worldwide. Such a uniquely dynamic system allows as to investigate the biological capacity and ecosystem elasticity in relation to these forcings. This project, at this state of knowledge, will be the first one that tries addressing the impact of the aforementioned anthropogenic drivers on the ecosystem behaviour (changes in water chemistry, metabolic activity and biodiversity). It will also advance the international state of the art in the following aspects: temporal resolution of the in situ acidification and phytoplankton physiology analysis, taxonomic resolution, combined taxonomic and metabolic analyses and molecular biodiversity.A buoy positioned at a point that integrates the most of the NA dynamics will serve as a hub for the continuous acquisition of the oceanographic and biological parameters. Together with the largest historical data set in the wider area and the most advanced approaches (in situ pH and phytoplankton physiology, taxonomy and analyses of metabolic activities), it will allow us an exhaustive insight in these interactions. At the end, this research will enable us to build scenarios of possible ecosystem reactions to predicted environmental changes in the NA and, in a wider sense, to all marine systems.]]></summary_en></project><project>
<id>1557</id><title_hr><![CDATA[Cjelogenomska analiza povezanosti Hashimotovog tiroiditisa]]></title_hr><title_en><![CDATA[Genome-wide association analysis of Hashimoto thyroiditis]]></title_en><user_id>63</user_id><user_firstLast_name>Vesna Boraska</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2013-11</proposal_call><code>UIP-2013-11-4950</code><acronim><![CDATA[HashimotoGWAS]]></acronim><duration>15.09.2014 - 14.01.2018</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Split School of Medicine]]></institution_en><team_members_id>118, 137, 3571, 388, 260, 611, 4749, 1067, 17744, 19036, 1113, </team_members_id><team_members_names><![CDATA[Tatijana Zemunik, Maja Barbalić, Ante Punda, Sanda Gračan, ANA BARIĆ, Vesela Torlak, Stana Tokić, Eleftheria Zeggini, Luka Brčić, Ivana Gunjača, Veselin Škrabić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Hashimoto thyroiditis, thyroid gland, genome-wide association analysis (GWAS), statistical genetics, single nucleotide polymorphism (SNP), biobank]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Autoimmune thyroid diseases (AITD) are very common and affect 2-5% of the general population. The most frequent form of AITD is Hashimoto thyroiditis (HT) that is characterised by progressive destruction of thyroid tissue. Many studies tried to unravel genetic contribution to HT development in the past few decades but with low success. The breakthrough of the genome-wide association studies (GWAS) tremendously increased the rate of detecting novel associations. However, HT has been unrepresented in the GWAS mostly because of the lack of large cohorts of HT patients and the performance of such study is a matter of urgency. We plan to recruit 500 HT patients and to create a DNA/serum/plasma biobank of deeply phenotyped HT patients that will serve as a powerful resource for current and future investigations. The aim of this study is to identify genetic variants underlying HT by performing the first GWAS focusing on HT exclusively. We will use newly recruited HT patients and 500 existing controls (from the “10,000 Dalmatians” study) in case-control GWAS and validate observed associations in an independent replication cohort. To further help in elucidating genetic contribution to HT we will perform pathway analysis and gene-interaction analysis using variety of environmental factors and medical records that will be collected from HT patients. We will also perform deep phenotype characterisation of HT patients that may provide additional clues about HT aetiology. This is timely planned study that aims to generate new knowledge that will advance our understanding of the genetic basis and underlying biological mechanisms of HT. This knowledge will be crucial in guiding the development of new prevention, diagnostic and therapeutic methods. Other benefits of this project include promotion of collaboration, transfer of knowledge, building of infrastructure and it will help in establishment of independent research carrier of principal investigator.]]></summary_en></project><project>
<id>1559</id><title_hr><![CDATA[Ultrazvučni sustav za određivanje parametara kompleksnih materijala u nelinearnim uvjetima rada]]></title_hr><title_en><![CDATA[Ultrasound system for  complex material parameters determination in the nonlinear working conditions]]></title_en><user_id>146</user_id><user_firstLast_name>Antonio Petošić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2013-11</proposal_call><code>UIP-2013-11-4996</code><acronim><![CDATA[ULTRASNON]]></acronim><duration>01.09.2014 - 31.12.2017</duration><status>Završio</status><financ_value>130.094,90 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>962, 1392, 1379, 3153, 284, 682, </team_members_id><team_members_names><![CDATA[Ivan Đurek, Nazenin Bassiri Gharb, Marko Budimir, Dražan Skelin, Dragan Damjanovic, Marijan Klarica, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[material parameters, ultrasound, modular measurement system, nonlinear effects, effciency factor]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The main objective of this project is to develop a new measurement procedure and to construct a modular measurement system for determination of complex material parameters that are used in ultrasound (US) systems  which are working in the nonlinear conditions. The materials&#39; parameters in existing US systems used in biomedicine and industry are determined at low excitation levels assuming linear physical principles and consistent thermodynamical conditions. This is different from real operating conditions where range of applied powers and types of excitation signals is various and very often far away from linear. The neglect of these nonlinearities in active and passive materials, used in the complete US system construction process, leads to the problem of the US systems’ efficiency factor in the nonlinear driving conditions. The construction of modular measurement system with included and modified interferometry and time of flight principle with added new measurement procedure is crucial for developing novel US systems with higher electroacoustic efficiency factors. The new method is based on tracking the resonant frequency changes of the nonlinear electro-mechanical-acoustical system for determination complex material parameters. The new modular measurement system will enable exposure of materials to the US fields with various driving conditions. Tracking the resonant frequency changes of excitated loading medium sample (active piezoceramic or passive construction elements or different types of loading mediums) is novel method for determination of material parameters when nonlinear effects appear in the loading mediums. As a result of more precise constructive material parameters determination, three prototypes of US systems with probes and electronic excitation circuits for applications in biomedicine and industry, with obtained higher electroacoustic efficiency factors will be developed, constructed and tested during this project.]]></summary_en></project><project>
<id>1560</id><title_hr><![CDATA[Održivost ekonomske politike i razvoja u Hrvatskoj]]></title_hr><title_en><![CDATA[Sustainability of Croatian Economic Policy and Development]]></title_en><user_id>503</user_id><user_firstLast_name>Jurica Šimurina</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-7031</code><acronim><![CDATA[SCrEPoDe]]></acronim><duration>01.10.2014 - 30.09.2018</duration><status>Završio</status><financ_value>50.913,27 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, </scie_field_hr><scie_field_en>Economy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Ekonomski fakultet u Zagrebu]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Economics and Business]]></institution_en><team_members_id>3966, 3909, 3635, 3957, 4150, 3729, 3747, 4093, 3801, 4626, 3914, 3874, </team_members_id><team_members_names><![CDATA[Alka Obadić, Irena Raguž Krištić, Tomislav Globan, Tomislav Sekur, Josip Tica, Ozana Nadoveza, Vladimir Arčabić, Šime Smolić, Tamara Boras, Tomislav Gelo, Marija Penava, Ana Andabaka Badurina, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[sustainability, economic structure, resources, public sector economics, spatial economics]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[RESEARCH QUESTION: Do Croatian economic policies lead to sustainability with respect to scarce resources, demographic changes, spatial effects and economic structure?Long term Croatian economic policy and development stem from both short term policies and long term sustainability. By combining macroeconomic and development policies, the long term objectives of sustainability of natural resources, public sector economics, demographic changes, spatial economics and overall economic structure may be achieved. Thus, the goals of this research stem from the above stand point, and include:•	Establish development policies for Croatia based on sustainable use of natural resources•	Show how change of age structure in Croatia affects fiscal sustainability and short and long run economic development•	Explore how three way interaction among increasing returns, transportation costs, and movement of factors of production affect international, regional and urban development•	Analyze structure of Croatian economy suitable for sustainable and deeper integration into the EU•	Define integrative policies which lead to sustainable development of Croatian economyFor achieving above mentioned goals, the project team is separated into four equally contributing groups and is structured as follows:1. Sustainability of economic development within the context of scarce natural resources.2. Sustainability of public sector economics and the labor market in the context of demographic changes in Croatia.3. Sustainability of the degree of centralization in the context of spatial (international, urban and regional) economics.4. Sustainability of current economic structure within the context of the EU integrationOutcomes of the research will be innovative approach to controversy of long vs. short term development and stability, as well as integrative approach to different, and thus far, insufficiently interconnected fields of economic research.]]></summary_en></project><project>
<id>1563</id><title_hr><![CDATA[Primjena frazeološke teorije u frazeografiji ]]></title_hr><title_en><![CDATA[Application of phraseological theory in phraseography ]]></title_en><user_id>3653</user_id><user_firstLast_name>Željka Fink-Arsovski</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-4054</code><acronim><![CDATA[FRAZLOGGRAF]]></acronim><duration>01.07.2014 - 30.06.2018</duration><status>Završio</status><financ_value>18.461,74 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filologija, </scie_field_hr><scie_field_en>Philology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>3577, 1477, 1516, </team_members_id><team_members_names><![CDATA[Branka Barčot, Anita Hrnjak, Antica Menac, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[phraseme, phraseology, phraseography, dictionaries, contrastive linguistics, Croatian, Slavic languages, non-Slavic languages]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The active development of phraseology as an independent linguistic discipline began in the former USSR in the 1950s. Phraseology is primarily a linguistic and culturally multi-layered discipline. The basic unit of phraseology is a phraseme (idiom). It consists of at least two components. Its characteristic is that it is not created in the process of speaking, but is included in discourse as an already known whole. Its main features are continuity of use, integrity and a solid structure, higher or lower degree of desemanticization, a colourful nature, expressiveness and connotative meaning. The project will primarily include theoretical work on analyzing Croatian phrasemes from various aspects. Furthermore, with the application of the method of contrastive analysis, structural, semantic, etymological, motivational and cultural similarities and differences between Croatian idioms and idioms of other Slavic and non-Slavic languages will be examined. We consider the latter to be extremely important because in this way Croatian idioms would be placed in the context of European idioms. The second part of the project proposal relates to phraseographical work. Phraseography is an area that deals with the issue of compiling phraseological dictionaries. The publication of several phraseological dictionaries is planned. Particularly important will be the two phraseological dictionaries which will be completely new in a conceptual sense (a trilingual dictionary of associations and a dictionary of gender-marked phrasemes). All dictionaries will be compiled according to the latest phraseographical methodology. In addition, we should mention the work on the updated edition of the Bibliography of Croatian phraseology. We believe both of these aspects to be very important for the recognition of Croatian phraseology and phraseography within European phraseology, phraseography, Slavic studies and philology.]]></summary_en></project><project>
<id>1578</id><title_hr><![CDATA[Multidisciplinarni klaster za istraživanje tranzicijskog kriminaliteta - trgovanje ljudima, korupcija i gospodarski kriminalitet]]></title_hr><title_en><![CDATA[Multidisciplinary Research Cluster on Crime in Transition - Trafficking in Human Beings, Corruption and Economic Crime]]></title_en><user_id>125</user_id><user_firstLast_name>Davor Derenčinović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-1949</code><acronim><![CDATA[Trans.Crim.]]></acronim><duration>01.01.2015 - 31.12.2018</duration><status>Završio</status><financ_value>59.893,95 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Pravo, </scie_field_hr><scie_field_en>Law, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Pravni fakultet u Zagrebu]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Law]]></institution_en><team_members_id>3828, 4083, 4111, 4199, 4292, 4357, 4492, 4457, 229, 3052, 4535, 580, 4165, 4158, 4222, 2814, 2928, 4522, 4297, 4187, 4274, 4763, 4774, 4955, 4467, 5073, 5549, </team_members_id><team_members_names><![CDATA[Maja  Munivrana Vajda, Anna-Maria Getoš, Aleksandar Maršavelski, Marta Dragičević Prtenjača, Vanja-Ivan Savić, Davorin  Lapaš, Peter Henning, Vanda Božić, Jasenko Marin, Iva  Savić, Dražen Dragičević, Hrvoje Lisičar, Nina Gumzej, Tihomir Katulić, Marko Jurić, Nikoleta Radionov, Mišo Mudrić, Richard Farkas, Marko Šikić, Lana Ofak, Frane  Staničić, Marko Turudić, Mateja Crnković, Ivana  Jaramaz Reskušić, Sanja Milivojevic, Suncana Roksandic Vidlicka, Leo Cvitanović, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[crime, transition,research cluster, trafficking in human beings, corruption, economic crime]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The first project research focus is human trafficking, modern age slavery that has been condemned by the ECHR as a gross human rights violation. The number of those identified as victims in Croatia remains low. However, there is no dispute that the dark number in this field is significant. This could be explained by the structural deficiencies of national anti-trafficking policies and disregard of research and multidisciplinary approach in addressing three key priority areas – that of prevention, protection of victims, and prosecution of perpetrators. The need for the research based policies is indispensible for Croatia as a new EU member state that has been under the risk of turning into a country of destination for victims from the Western Balkan countries as well as from the countries either affected from internal instabilities and conflicts (e.g. Syria) or from the African countries (e.g. Nigeria). Therefore, the aim of this project is to contribute, through establishment of fully operational informal network of experts from different disciplines, in promoting research based policies and to provide support for establishment of National Rapporteur on THB (this is an obligation under the Directive 2011/36/EU that still has not been fully implemented by Croatia). The second research focus is corruption and economic crime, major obstacles for further development of society stretched between systemic dysfunctions characteristic for transition period and the rule of law standards formally accepted through the process of European integration. Informal network of experts will address the issues of liability of legal persons for corruption and economic criminal offences, shortcomings in legislation and case law, legislation that regulate access to information etc.]]></summary_en></project><project>
<id>1579</id><title_hr><![CDATA[Diofantove m-torke, eliptičke krivulje, Thueove i indeksne jednadžbe]]></title_hr><title_en><![CDATA[Diophantine m-tuples, elliptic curves, Thue and index form equations]]></title_en><user_id>95</user_id><user_firstLast_name>Andrej Dujella</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-6422</code><acronim><![CDATA[DIOPHANTINE]]></acronim><duration>01.07.2014 - 30.06.2018</duration><status>Završio</status><financ_value>101.962,27 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>1267, 1262, 1282, 2600, 3264, 1264, 2990, 1348, 1251, 1312, 4086, 17746, 23281, </team_members_id><team_members_names><![CDATA[Ivica Gusić, Alan Filipin, Borka Jadrijević, Zrinka Franušić, Mirela Jukić Bokun, Ana Jurasić, Tomislav Pejković, Ivan Soldo, Petra Tadic, Sanda Bujačić, Nikola Adžaga, Marija Bliznac, Vinko Petričević, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Diophantine equations, elliptic curves, Diophantine approximations, polynomials, cryptography]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The proposed project will coordinate and support research activities of Croatian number theory group. One of the main topics of research in this project will be Diophantine m-tuples (sets with the property that the product of its any two distinct elements increased by 1 is a perfect square) and their generalizations. The first Diophantine quadruple {1,3,8,120} was found by Fermat. Baker and Davenport proved that Fermat&#39;s set cannot be extended to a quintuple. This result motivated the famous conjecture that there does not exist a Diophantine quintuple. Dujella proved that there does not exist a Diophantine sextuple and that there are only finitely many Diophantine quintuples. Recently, Filipin, Fujita and Elsholtz significantly improved previously known upper bounds for the number of Diophantine quintuples, but the main conjecture still remains open. Various generalizations of Diophantine m-tuples will be studied, in particular, considering the problem in the rings of integers of number fields of small degree.  Diophantine triples were used by Dujella in construction of high-rank elliptic curves over Q and Q(T) and new results in that direction are expected. In determining exactly the Mordell-Weil group of several elliptic curves over Q(T), an important tool is recent algorithm by Gusić and Tadić for finding rationals at which the specialization map is injective. We plan to improve and extend this algorithm for elliptic curves over K(T) for general number fields K. Members of the group will also work on Thue, Thue-Mahler and index forms equations, problems related to sums of divisors, polynomial root separation and applications of Diophantine approximations to cryptanalysis. The results of the research will be published in respectable journals and presented on international conferences. Through this project we will intensify our scientific connections with international number-theorists and qualify young researchers for scientific research in number theory.]]></summary_en></project><project>
<id>1585</id><title_hr><![CDATA[Primjena metode scenarija u planiranju i razvoju ruralnih područja Hrvatske]]></title_hr><title_en><![CDATA[Croatian Rural Areas: Scenario-based Approach to Discuss Planning and Development]]></title_en><user_id>3724</user_id><user_firstLast_name>Aleksandar Lukić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2013-11</proposal_call><code>UIP-2013-11-4513</code><acronim><![CDATA[Croruris]]></acronim><duration>01.10.2014 - 30.09.2017</duration><status>Završio</status><financ_value>67.370,48 eur</financ_value><scie_area_hr>Društvene znanosti, Biotehničke znanosti, Prirodne znanosti, </scie_area_hr><scie_area_en>Social sciences, Biotechnical sciences, Natural sciences, </scie_area_en><scie_field_hr>Ekonomija, </scie_field_hr><scie_field_en>Economy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>6156, 6662, 4934, 4600, 4881, 6407, 5671, 5139, 4846, 6137, </team_members_id><team_members_names><![CDATA[Dane Pejnović, Maja Štambuk, Anica Čuka, Ornella Mikuš, Ivan Zupanc, Ivana Lučev, Ivan Čanjevac, Petra Radeljak, Luka Valožić, Marin Cvitanović, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[scenario, rural areas, typology, planning, modelling, Delphi, Croatia]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The main anticipated result of the interdisciplinary CRORURIS study is the production of a set of alternative future scenarios for Croatian rural areas in 2030 with the goal of encouraging informed and evidence-based public debate on rural futures. Rural areas account for almost 90% of the land and are home to almost half of the population, both in Croatia and the EU. They are still the most important food production zones in Europe, although this primary function has been challenged by numerous modernization and globalization processes and complemented by other economic, social, cultural, and environmental functions. As a result, we have witnessed the (re)emergence of heterogeneous and diversified rural areas, juxtaposing depopulation and land abandonment in some regions, and tourist development or agricultural intensification in others. Given their size, population number, functions and variety of challenges they face, the question of future of rural areas is one of the most pressing issues in Europe today. This is evident from recent scenario-based approaches to study future trends and driving forces for rural Europe, both in academic and political discourse, on national and EU level (e.g. SCENAR 2020, EURURALIS etc.). On the other hand, although the majority of rural areas in Croatia face tremendous demographic and economic challenges, to our knowledge no scenario-based research has been done and only a few partial impact analyses have been conducted in recent Croatian agricultural policy. Therefore, the main objectives of the CRORURIS study are as follows: 1. to develop a conceptual framework for understanding recent change in rural Croatia; 2. to develop methodological framework for identifying predominant trends and key uncertainties, differentiating them geographically and projecting them forward using statistical modelling and Delphi method; 3. to construct alternative future scenarios and relate them to the context of rural Europe.]]></summary_en></project><project>
<id>1588</id><title_hr><![CDATA[Istraživaje prirodnih spojeva i aroma: kemijsko profiliranje i otkrivanje potecijala]]></title_hr><title_en><![CDATA[Research of natural products and flavours: chemical fingerprinting and unlocking the potential]]></title_en><user_id>367</user_id><user_firstLast_name>Igor Jerković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-8547</code><acronim><![CDATA[NaPro-Flav]]></acronim><duration>01.06.2014 - 31.05.2018</duration><status>Završio</status><financ_value>87.563,15 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Kemijsko-tehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Chemistry and Technology]]></institution_en><team_members_id>664, 666, 3752, 1139, 1133, 507, 1520, 4186, 4185, 771, </team_members_id><team_members_names><![CDATA[Ani Radonić, Marina Zekić, Marina Kranjac, Maja Kliškić, Senka Gudić, Carlo Ignazio Giovanni Tuberoso, Zvonimir Marijanović, Dragan Bubalo, Lidija Svečnjak, Goran Baranović, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[natural products, flavours, preparative techniques, chromatography, spectroscopy, antioxidant assays, corrosion inhibition assays]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The proposed project develops up-to date topic in the subject area, offers high-quality research of natural products (NPs) and flavours (FLs) and tends to impact the biodiversity, traceability and authentication issues of targeted samples (major EU concerns), as well as to unlock the potential (useful activities of the samples/NPs). Targeted samples are unexplored or insufficiently investigated honeys, honeydews, bee-products, wines, cheese, others. While characteristic NPs (secondary metabolites) already possess flavours, other flavour compounds can derive from precursors during processing, fermentation, dry-curing, heating, others (e.g. Maillard reactions, Strecker degradations, retro-aldol reactions, Amadori rearrangements, heterocyclizations, lipid oxidations and others). NPs/FLs isolation involves application of selective preparative procedures followed by the organic analysis applying modern chromatographic and spectroscopic techniques. Specific project goal is to determine reliable chemical fingerprints of targeted samples depending on biodiversity of natural sources in different regions. Varieties of acetate, shikimate, mevalonate and/or deoxyxylulose biosynthetic pathway derivatives are expected to be found. Among them, it can be possible to find specific or nonspecific chemical biomarkers characterizing certain sources. In addition, the obtained NPs or selected samples will be evaluated in order to unlock their potential, particularly antioxidant activity by different assays and corrosion inhibition potential with in-situ and ex-situ electrochemical/non-electrochemical techniques. Project work plan includes: 1) the samples selection and preliminary characterisation; 2) set-up of preparative/chromatographic/spectroscopic methods followed by elaboration of the obtained chemical fingerprints); 3) set-up of antioxidant/corrosion inhibition assays followed by unlocking the samples/NPs potential; 4) training of young researchers/cooperation.]]></summary_en></project><project>
<id>1590</id><title_hr><![CDATA[Taksonomija, Ekologija i Uporaba rogača (Ceratonia siliqua L.) i lovora (Laurus nobilis L.) u Hrvatskoj]]></title_hr><title_en><![CDATA[Taxonomy, Ecology and Utilization of Carob Tree (Ceratonia siliqua L.) and Bay Laurel (Laurus nobilis L.) in Croatia]]></title_en><user_id>372</user_id><user_firstLast_name>Siniša Srečec</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-3304</code><acronim><![CDATA[TEUCLIC]]></acronim><duration>07.07.2014 - 06.10.2018</duration><status>Završio</status><financ_value>95.553,20 eur</financ_value><scie_area_hr>Biotehničke znanosti, Prirodne znanosti, Biomedicina i zdravstvo, </scie_area_hr><scie_area_en>Biotechnical sciences, Natural sciences, Biomedicine and health sciences, </scie_area_en><scie_field_hr>Biotehnologija, </scie_field_hr><scie_field_en>Biotechnology, </scie_field_en><institution_hr><![CDATA[Veleučilište u Križevcima]]></institution_hr><institution_en><![CDATA[Križevci University of Applied Sciences]]></institution_en><team_members_id>4381, 4864, 5669, 5474, 6201, 313, 6170, 6304, 6326, 5692, 4916, 5084, 6046, 5510, 5662, 5690, 5630, 6097, 6236, 5853, 5364, 6184, 1317, </team_members_id><team_members_names><![CDATA[Dario Kremer, Snježana Bolarić, Nada  Bezić, Dubravka Dujmović Purgar, Irena Vedrina-Dragojević, Maja Popović, Ingrid Bauman, Marija Vukobratović, ŽELIMIR VUKOBRATOVIĆ, Ivka Kvaternjak, Ksenija Karlović, Renata Jurišić Grubešić, Nives Marušić, Gordan Mršić, Daniel Špoljarić, Zvjezdana Augustinović, Dejan Marenčić, Ivna Dragojević Müller, Maja Benković, Tomislava Peremin Volf, Renata Erhatić, Marinko Petrović, Valerija Dunkić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[carob tree, Ceratonia siliqua L., bay laurel, Laurus nobilis L., biodiversity, utilization]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Carob tree (Ceratonia siliqua L.) is nutritionally and protectively very valuable plant, especially seeds which are widely used in the food industry. Carob pods and juice has a very important role in diet of Mediterranean countries. Bay laurel (Laurus nobilis L.) is also nutritionally and protectively very valuable plant overspread on the Mediterranean basin. The most important parts of the bay laurel plant are leaves which are used in traditional medicine, and in the food, pharmaceutical and cosmetic industries. Both species are also an important component of the Mediterranean vegetation and grows in marginal and prevailing calcareous soils. Since there is limited knowledge about Croatian populations of carob tree and bay laurel this studies will be conducted to determine morphological, genetic, phytochemical and ecological traits of Croatian populations of these species. Morphometric investigations will be made on leaves and fruits (carob tree) samples gathered in situ, while the genetic variability will be determined using AFLP analysis of genomic DNA isolated from the leaves. The content of polyphenolic compounds, antioxidant activity in vitro with the use of UV-Vis spectrophotometer, and the share of macro and microelements using emission spectrometry (AES) will be determined in the leaves and fruits samples. Carob based soft drinks and pastry fillings will be developed as new products on Croatian market. Additionally, possible positive effects of addition supplement of carob tree in standard food for animals on health and production parameters in weaned pigs as the natural replacement of antibiotic growth promoters will be investigated.]]></summary_en></project><project>
<id>1596</id><title_hr><![CDATA[Pouzdanost konstrukcije oštećenog naftnog tankera u Jadranskom moru]]></title_hr><title_en><![CDATA[Structural reliability of damaged oil tanker in the Adriatic Sea]]></title_en><user_id>810</user_id><user_firstLast_name>Joško Parunov</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-8658</code><acronim><![CDATA[DATAS]]></acronim><duration>01.09.2014 - 31.08.2018</duration><status>Završio</status><financ_value>126.973,39 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Brodogradnja, </scie_field_hr><scie_field_en>Naval architecture, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>6629, 6823, 6385, 6793, 6254, 6626, 6227, 5584, 6309, 6166, 6437, 6414, 6209, 6640, 5212, 6271, 6483, 17869, 17868, 17787, </team_members_id><team_members_names><![CDATA[Vedran Žanić, Većeslav Čorić, Andreja Werner, Nastia Degiuli, Smiljko Rudan, Vedran Slapničar, Jerolim Andrić, Ivan Ćatipović, Stanislav Kitarović, Pero Prebeg, marko tomić, Karlo Pirić, Maro Ćorak, Jadranka Radanović, Branka Bužančić Primorac, Luka Mudronja, Ivan Munić, Marko Katalinic, Ivana Martić, Ivana Gledić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[oil tanker, Adriatic sea, damaged ship, structural reliability, risk assessment]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The aim of the project is to propose methodology of structural safety assessment of the damaged oil tanker in the Adriatic Sea and to set-up procedure for rational decision making of ship in the situations requiring emergency response actions. This can also be used to develop more rational rules and regulations related to the traffic of large ships operating in the Adriatic and to investigate possibilities of a ship structural design improvement with respect to the most dangerous incident types. Despite advancements in navigation systems, ship accidents continue to occur, the most recent one being the grounding of a cruise ship Costa Concordia. These accidents have resulted in the loss of cargo, pollution of environment, and most unfavorable the loss of life. Accidental damages of ships can occur in any number of ways. The two cases which exhibit most concerns are the collision between ships and hard grounding on seabed. When a ship is damaged, the operators need to decide on immediate repair actions by evaluating the effects of the damage on safety of the ship by considering simultaneously effects of the damage in the hull girder ultimate bending moment and in the applied loads (wave and still-water induced bending moments). In general, as the consequence of an accident still water loads on ship will considerably increase, while the ship strength will decrease. Disaster of the tanker Prestige in 2002 clearly showed that the ship in damaged condition can be broken due to the above mentioned phenomenon and sink as the most unfavorable outcome of such an accident with likely spillage of a large amount of pollutant oil on board.Since the Adriatic is an enclosed sea basin, with the low level of the activity of the sea waves and current, an accident of the oil tanker with significant oil spill would make irreversible ecological disaster with enormous economic losses. Therefore, safety of oil transportation in the Adriatic is a major concern of the whole society.]]></summary_en></project><project>
<id>1598</id><title_hr><![CDATA[Elektrokemijski superkondenzator visoke snage i velikog sadržaja energije za primjenu u električnim vozilima]]></title_hr><title_en><![CDATA[High power-high energy electrochemical supercapacitor for hybrid electric vehicles]]></title_en><user_id>961</user_id><user_firstLast_name>Zoran Mandić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-8825</code><acronim><![CDATA[ESUP-CAP]]></acronim><duration>03.11.2014 - 02.11.2018</duration><status>Završio</status><financ_value>126.856,46 eur</financ_value><scie_area_hr>Tehničke znanosti, Prirodne znanosti, </scie_area_hr><scie_area_en>Technological sciences, Natural sciences, </scie_area_en><scie_field_hr>Kemijsko inženjerstvo, </scie_field_hr><scie_field_en>Chemical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet kemijskog inženjerstva i tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Chemical Engineering and Technology]]></institution_en><team_members_id>3029, 3035, 3651, 4131, 5278, 6109, 17810, 19020, 21370, </team_members_id><team_members_names><![CDATA[Višnja Horvat-Radošević, Katja Magdić, Marijana Kraljić Roković, Suzana Sopčić, Gabrijela Slavić, Željko Ban, Denis Sačer, Davor Antonić, Antonio Ivanković , ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Supercapacitors, electrochemical energy sources, electric vehicles, renewable energy, carbon electrodes, conducting polymers]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[In the context of renewable and “clean” energy sources, the main aim of the present project is to provide a technology output for the novel, high power-high energy electrochemical supercapacitor device that could be implemented in hybrid electric vehicles. The project addresses an interdisciplinary research and combines fundamental and applied research activities in chemical, electrical and environmental engineering fields. The highest possible scientific and technological impact of the project is supposed to be ensured by joining of the human and experimental resources of several different Croatian’s groups. The novel, high power-high energy electrochemical supercapacitor device will be based on hybridization of two different types of electrodes (double-layer and pseudo-capacitive) in a respective electrolyte. Various forms of carbon and carbon based binary and ternary composites with transition metal oxides and/or conducting polymers will be tested as negative and positive electrodes, respectively. For being competitive in the area of energy storage, the tested electrodes should fulfil the requirements of high specific capacitance, long cycle-life, good charge/discharge efficiency, low self discharge and adequate operating voltage. The project is planned to be realized mostly on the basis of fundamental experimental research directed towards increasing of the basic knowledge comprising choice of material, proper design of electrodes and careful elucidation of all underlying physical and chemical processes at active electrode/electrolyte interfaces. The results of fundamental experimental research will be utilized for selection of proper electrodes, their arrangement into electrochemical supercapacitor device, optimization of device to the energy content and power ability, testing of device in practical environment and implementation of device into hybrid electrical vehicle. ]]></summary_en></project><project>
<id>1603</id><title_hr><![CDATA[Karakterizacija niskotemperaturne molekulske dinamike sustava s neuređenom rešetkom metodom ESR]]></title_hr><title_en><![CDATA[Low-temperature molecular dynamics of systems exhibiting lattice disorder probed by ESR]]></title_en><user_id>510</user_id><user_firstLast_name>Marina Ilakovac Kveder</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-1108</code><acronim><![CDATA[DESiRe]]></acronim><duration>01.09.2014 - 31.08.2018</duration><status>Završio</status><financ_value>105.096,96 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>3280, 3546, 3545, 1213, 4209, 2647, 17790, </team_members_id><team_members_names><![CDATA[Boris Rakvin, Mladen Andreis, Srećko Valić, Dalibor Merunka, Nadica Maltar Strmečki, Dijana Žilić, Jurica Jurec, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[ESR, disorder, boson peak, spin relaxation, spin frustration]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Systems exhibiting geometrical frustration challenge contemporary condensed-matter physics due to the fact that they exhibit strange dynamical properties such as boson peak excitations, which strongly deviate from the standard Debye model. Therefore, the quest for a self-consistent theory applicable for description of systems with lattice disorder is a fundamental issue. Despite the efforts put into investigation of vibrational excitations in disordered systems at low temperatures, the consensus about their physical origin is still lacking. This project aims to address the subject by fully exploiting the advantage of embedded paramagnetic centres through focusing on their relaxation behaviour, which bears the information about the local frustration of the environment. The energy exchange within the spin system and between the spin system and the lattice will be detected by electron spin resonance spectroscopy (ESR) as a function of disorder in the vicinity of the paramagnetic centre. This we can control by preparing the host matrix in the glassy, supercooled or crystalline state. We propose to investigate the specific molecular dynamics due to the presence of disorder in the system while switching the very same compound doped with paramagnetic centres from disordered to more ordered state, such as from glassy to crystalline state. Additionally, the microscopic picture of local disordered sites will be examined in other systems doped with paramagnetic centres such as various polymer matrices or hydrogen-bonded crystals. The origin of local disorder will be correlated with the influence of different numbers of hydrogen bonds in the vicinity of paramagnetic site as well as with the degree of local spin frustration. We expect that this comparative study will enlighten the peculiarities of vibrational density of states of amorphous materials and contribute towards development of the unique model of low-temperature molecular dynamics of disordered systems in general.]]></summary_en></project><project>
<id>1617</id><title_hr><![CDATA[Modeliranje ekonomskog rasta - napredno sekvenciranje i algoritam predviđanja]]></title_hr><title_en><![CDATA[Modelling Economic Growth - Advanced Sequencing and Forecasting Algorithm]]></title_en><user_id>3894</user_id><user_firstLast_name>Marinko Škare</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-9481</code><acronim><![CDATA[MEGASFORA]]></acronim><duration>16.06.2014 - 15.06.2018</duration><status>Završio</status><financ_value>73.571,48 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, </scie_field_hr><scie_field_en>Economy, </scie_field_en><institution_hr><![CDATA[Sveučilište Jurja Dobrile u Puli]]></institution_hr><institution_en><![CDATA[Juraj Dobrila University of Pula]]></institution_en><team_members_id>1166, 2963, 1268, 1331, 4628, 1094, 1055, 6579, 6549, 5351, 5675, 5391, 5396, 5635, 5036, 4659, 4863, 5062, 6832, 19122, </team_members_id><team_members_names><![CDATA[Steve Keen, Guglielmo Maria Caporale, Roman Semko, Daniel Tomić, Saša Stjepanović, Hazbo Skoko, Sanja Blažević, Tea Hasić, Sabina Lacmanović, Katarina Kostelić, Nawazish Mirza, Danijela Rabar, Soumitra Sharma, TOMASZ WOLOWIEC, Manuel Benazić, ROMINA  PRŽIKLAS DRUŽETA, Tea  Golja, Dean Sinković, Valter Boljunčić, Mieta Bobanović, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Growth, forecasting, algorithm, dynamic models, golden triangle model]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The main objective of the project is to give a final and scientifically based answer to the question whether economic growth can be forecasted and business cycles predicted? A practical objective of the proposed research project is to build an optimal economic growth/cycle model for Croatia using Advanced Growth Sequencing and Forecasting Algorithm (AGSIFAL) that we plan to build. In order to do so, an algorithm (selected from the best of artificial neural network model, structural econometric model, dynamic general equilibrium model, nonlinear econometric model, golden triangle model) for cycle/growth sequencing and forecasting will be developed. Sequencing of the economic growth on a international scale (119 countries) will be performed using business cycle tracer methods and novel golden triangle model developed by Škare (2010). For this purpose, advanced cycle/growth algorithm will be created. Using individual country data as primer, we plan to isolate growth determinants using three dimensional golden triangle model and spectral analysis techniques.  Output, inflation and employment form the three dimension of the cycle/growth triangle that will be used for sequencing growth. After a growth sequencing is finished, a best forecasting algorithm is built from the derived growth sequencing bases. Pairing isolated growth determinants help us to rebuild a growth sequence. Using different algorithm models, reconstructed economic growth series is compared to the actual growth series (observed data). Algorithm resulting in the smallest forecast error (RMSE) is selected as optimal to explain economic growth and predict business cycles. EThis conclusion will have important theoretical and policy implications both for the science of economics and economic agents on the market. ]]></summary_en></project><project>
<id>1619</id><title_hr><![CDATA[Razvoj i upotreba modela za procjenu potencijala za rast za mala i srednja poduzeća u Hrvatskoj]]></title_hr><title_en><![CDATA[Development and application of growth potential prediction models for small and medium enterprises in Croatia]]></title_en><user_id>2825</user_id><user_firstLast_name>Nataša Šarlija</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-3933</code><acronim><![CDATA[CROSMEGROWTH]]></acronim><duration>01.07.2014 - 30.06.2018</duration><status>Završio</status><financ_value>60.817,57 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, </scie_field_hr><scie_field_en>Economy, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Ekonomski fakultet u Osijeku]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Economics]]></institution_en><team_members_id>4247, 6530, 5265, 305, 5065, 4797, 17875, </team_members_id><team_members_names><![CDATA[Sanja Pfeifer, Slavica (Vjekoslava) Singer, Marina Jeger, Danijel Grahovac, Anamarija Delić, Sunčica  Oberman Peterka, Ana Bilandžić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[prediction of growth potential, high-growth SMEs, creative industry, policy recommendation for high growth SMEs, access to finance for high-growth SME]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The importance of high-growth enterprises for job creation has been widely substantiated by economic research in recent years. The number and share of high-growth enterprises is relatively small, but the number and share of jobs they create is disproportionally large. The small and medium enterprises with the potential of growth are in the focus of this project. Two overarching goals of this project are:1.	Development of growth potential prediction models for SMEs in CroatiaThe main activities leading up to this goal are: (i) to analyse previous studies relevant for the topic of SMEs&#39; growth potential; (ii) to develop growth potential prediction models for SMEs in Croatia; (iii) to make the models for assessing growth potential available to SMEs to use for purposes of assessing and improving their businesses; (iv) to compare differences in growth potential among SMEs from main industries; (v) to analyse growth potential of SMEs within creative industries and within manufacturing industries.  2.	Providing recommendations to policy makers, recommendation for development of educational programs for SME owners and managers, and recommendations related to sources of finance available to SMEsBased on the research results and models created as part of this project, the main recommendations related to growth potential of SMEs will cover areas of: (i) policy making; (ii) education; and (iii) sources of finance. In recent years policy makers have shown increased interest in fostering fast growing enterprises as they are seen as a key driver of economic growth and employment. Studies conducted in listed companies have showed that two key aspects in supporting high-growth companies are education and access to finance. To allow for comparison of other countries with Croatia, results of this project will be published in relevant scientific journals. To help boost Croatian economy, the results will be presented to all stakeholders interested in this topic.]]></summary_en></project><project>
<id>1630</id><title_hr><![CDATA[Molekularna epidemiologija nekih invazijskih oboljenja divljih životinja]]></title_hr><title_en><![CDATA[Molecular epidemiology of selected parasitic diseases of wildlife]]></title_en><user_id>3919</user_id><user_firstLast_name>Dean Konjević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2013-11</proposal_call><code>UIP-2013-11-3421</code><acronim><![CDATA[EpiMol]]></acronim><duration>01.09.2014 - 31.08.2017</duration><status>Završio</status><financ_value>128.342,96 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo, Prirodne znanosti, Biotehničke znanosti, </scie_area_hr><scie_area_en>Biomedicine and health sciences, Natural sciences, Biotechnical sciences, </scie_area_en><scie_field_hr>Veterinarska medicina, </scie_field_hr><scie_field_en>Veterinary medicine, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Veterinarski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Veterinary Medicine]]></institution_en><team_members_id>6172, 6141, 5928, 6315, 5763, 6460, 6444, 6598, 4742, 17766, </team_members_id><team_members_names><![CDATA[Ana Galov, Haidi Arbanasić, Krešimir Krapinec, Julian Drewe, Marina Pavlak, Magda Sindičić, Franjo Martinković, Živičnjak Tatjana, Krešimir Severin, Miljenko Bujanić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[molecular epidemiology, wildlife, parasitology, MHC genes, GIS modelling]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Wildlife diseases are increasingly important field of veterinary medicine, conservation medicine, and protection of human health. Of all wildlife diseases parasitic diseases participate with 75%. In this project, selection of diseases encompasses potentially fatal diseases with high economic impact, frequently present disease with mainly subclinical course, and potential zoonotic diseases. Main objectives of the project are to: 1) determine the occurrence of selected parasitic diseases of gastrointestinal and respiratory system in red deer, roe deer, wild boar and jackal, 2) determine environmental factors that contribute disease occurrence, 3) determine the epidemiology of selected parasitic disease of wildlife, 4) analyse MHC genes expression in animals with different health status, and 5) analyse obtained results with molecular epidemiology tools. This will be achieved by interdisciplinary research team (composed of veterinarians, biologists and forester) divided in four main topics: parasitology, environmental conditions and GIS modelling, MHC genes polymorphism in wildlife and epidemiology and molecular epidemiology. Other objectives of the project are to facilitate establishment of internationally competent multidisciplinary research team through research, cooperation and continuing professional development and to enhance development of molecular epidemiology in Croatia. With such comprehensive approach proposed project offers for the first time in Croatia creation of multidisciplinary team that will analyse all aspects of wildlife diseases and important environmental factors. Furthermore, molecular epidemiology will provide insights into susceptibility to disease and potential survival rate that is dependent on major histocompatibility complex variations.]]></summary_en></project><project>
<id>1641</id><title_hr><![CDATA[Liječenje neuropatske boli stimulacijom spinalnog ganglija]]></title_hr><title_en><![CDATA[Treating neuropathic pain with dorsal root ganglion stimulation]]></title_en><user_id>4000</user_id><user_firstLast_name>Damir Sapunar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-4126</code><acronim><![CDATA[NeuroMod]]></acronim><duration>15.12.2014 - 14.12.2019</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Split School of Medicine]]></institution_en><team_members_id>768, 4233, 4510, 4384, 4379, 4511, 4417, 4561, 3385, 6089, 6077, 17768, 21335, </team_members_id><team_members_names><![CDATA[Adriana Banozic, Antonia Jeličić Kadić, Livia Puljak, Marta Balog, Senka Blažetić, Vedrana Ivić, Robert Blažeković, Ozana Katarina Tot, Ivica Grković, Danijel Nejašmić, Damir Kovačić, Tihana Repić, Ivana Vuka, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[neuropathic pain, nerve injury, neuromodulation, dorsal root ganglion, ganglionic field stimulation, T-junction, microelectrode arrays]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Neuropathic pain is a debilitating disease of the somatosensory system that has a huge socio-economic impact. Numerous studies, including those from our laboratory have established that the injured dorsal root ganglion (DRG) is the important site for pathophysiologic changes that lead to development of neuropathic pain. Although DRG neurons are critical for the onset of neuropathic pain, there are no relevant clinical treatments for neuropathic pain that target this organ. With this proposal we aim to prove that neurostimulation techniques can be successfully used to manipulate neuronal function at the level of experimentally injured DRGs. In order to test this hypothesis we will construct a fully implantable neuronal stimulator for freely moving rats, devise an implantation technique and define stimulation protocols. This stimulator will be tested in rats with two types of experimentally induced nerve injury; spinal nerve ligation and carrageenan-induced inflammation model. Since this invasive procedure bears substantial risk of inflammation and other adverse neural tissue response, which can induce pain per se, we will also investigate connective tissue fibrosis and neuroinflammatory response in neural tissue of DRG and dorsal horn. The effect of the stimulation on excitability of injured DRG neurons will also be tested in vitro. Our last aim builds on our previous study in which we showed that neuronal injury may disable T-junction filtering and thereby increase the net conduction of afferent traffic. With this proposal we will test whether stimulation can modulate filtering properties of DRG T-junction. This will be addressed using recordings from injured sensory neurons of dorsal root ganglia excised from adult rats, and recently developed methodology that will allow us to electrically visualize action potential propagation in DRG neurons grown over custom microelectrode arrays.]]></summary_en></project><project>
<id>1643</id><title_hr><![CDATA[Uokvireno ziđe - kompozitni nosivi sustav kod armirano-betonskih zgrada]]></title_hr><title_en><![CDATA[Frame - masonry composites for modelling and standardization]]></title_en><user_id>3000</user_id><user_firstLast_name>IVICA GULJAŠ</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-3013</code><acronim><![CDATA[FRAmed-MAsonry]]></acronim><duration>01.09.2014 - 31.08.2017</duration><status>Završio</status><financ_value>96.068,75 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Građevinarstvo, </scie_field_hr><scie_field_en>Civil engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Građevinski i arhitektonski fakultet Osijek]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Civil Engineering and Architecture Osijek]]></institution_en><team_members_id>3693, 2730, 3637, 3000, 4956, 3178, 3560, 3043, 3049, 3699, 2971, 1408, 7253, 3063, 765, 6190, 6177, 4046, 7284, 4805, 5368, 7288, 7309, 7489, 7389, </team_members_id><team_members_names><![CDATA[Damir Markulak, Damir Varevac, Petar Brana, IVICA GULJAŠ, MIRJANA BOŠNJAK-KLEČINA, JURKO ZOVKIĆ, Đurđica Matošević, Tanja Kalman Šipoš, Marin Grubišić, Goran Gazić, Mario Galić, Ivan Kraus, Damir Džakić, Davorin Penava, Mehmed Čaušević, Tatjana Isaković, Matej Fischinger, Veronika  Shendova, Golubka Nechevska-Cvetanovska, Đorđe Lađinović, Mustafa Hrasnica, Santiago Pujol, Schwarz Jochen Bernhard Rudolf, Christoph Butenweg, Mete Sozen, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[r/c frames, masonry infill, behavior, safety, modelling, standardization, framed-masonry]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[In r-c frames infilled with masonry (framed-masonry) the infill walls stiffen the frame and reduce the first-mode period leading to a reduction in drift response to strong ground motion. At the same time, the addition of the masonry wall to the frame tends to increase the base-shear response and reduce the drift capacity of the structure. The increase of lateral force and reduction of drift capacity leads to serious vulnerabilities unless proper proportioning is exercised. For frames with competent walls, the challenge for safe and economical design is to be able to take advantage of the stiffening but to make certain that the increase in lateral forces and reduction in drift capacity do not handicap performance. Available evidence has pointed out that shear strength of the confining column is the &#39;&#39;Achiless&#39;s heel&#39;&#39; of the system. Solution of the problem requires understanding the behavior of masonry and concrete subjected to dynamic and random loading reversals, a challenge that demands testing under reasonably realistic conditions for confident analysis of the problem and its generalization.This is a proposal to investigate the safety and behavior of buildings with masonry-infilled r-c frames through near full-scale dynamic earthquake-simulation tests accompanied by supporting pseudo-dynamic tests of structural assemblies and components and by calibrated analytical solutions. The overall goal is to develop pragmatic methods, by cooperative efforts of team members and co-working international body, for design, safety evaluation and standardization. Because framed-masonry serve both architectural and structural demands efficiently, people in seismic regions live and will continue to live in buildings of this type. An organized solution of the safety of such construction is essential. This proposal intends to put the &#39;&#39;framed-masonry&#39;&#39; composite up as a full-fledged building type, it is &#39;&#39;transformative&#39;&#39; and will change design practice.]]></summary_en></project><project>
<id>1650</id><title_hr><![CDATA[Stvaranje pšenice za budućnost-potraga za novim genima iz postojećih izvora]]></title_hr><title_en><![CDATA[Creating wheat for the future–quest for the new genes in the old gene pool ]]></title_en><user_id>3812</user_id><user_firstLast_name>Sonja Petrović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2013-11</proposal_call><code>UIP-2013-11-2000</code><acronim><![CDATA[PHENOWHEAT]]></acronim><duration>16.06.2014 - 15.07.2017</duration><status>Završio</status><financ_value>110.558,10 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Fakultet agrobiotehničkih znanosti Osijek]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Agrobiotechnical Sciences in Osijek]]></institution_en><team_members_id>381, 5094, 4574, 4054, 5925, </team_members_id><team_members_names><![CDATA[Sonja Marić, Tihomir Čupić, Andrijana Rebekić, Ivana Rukavina , Luka Drenjančević, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[wheat, adaptability, phenotyping, SSR, DArT, association mapping, candidate genes]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Around 20% of human food productions relays on wheat. Climate change evokes new demands for successful wheat breeding such as adaptability to various abiotic stress factors. The most important traits that are affected with climate changes such as drought are yield and quality. Drought tolerance in wheat is quantitative trait with very complex phenotype and genetic control. Significant number of wheat traits has different influence level on drought tolerance. Current global research trend is directed toward development of functional markers linked with wheat adaptability traits. Functional markers are derived from polymorphic sites within the gene that are directly associated with phenotypic variation. Proposed project includes total of 364 wheat accessions originated from five continents. Aims of the project are: assessment of phenotypic and molecular genetic diversity of wheat breeding germplasm; identification of existing functional markers for agronomical important traits in tested germplasm; identification of marker-trait associations; outlining the most suitable parents for future crossing and breeding programs. Project will include phenotyping of traits that are linked with wheat adaptability to drought. This project will contribute to improvement of knowledge of wheat genome research and detection of candidate genes for major marker-traits associations. Knowledge gained through this project will be helpful to better understand genetic control of wheat traits important for adaptation to climate change and drought tolerance. Project will bring out new skills to research group and to research institutions in Croatia by utilisation of DArT markers on wheat for the first time in Croatia. Project will also contribute to wheat selection – research will point out best parents for crossing and it will enable development of new wheat breeding population for further selection and research.]]></summary_en></project><project>
<id>1651</id><title_hr><![CDATA[Mjerenje svojstava Higgsovog bozona i potraga za novom fizikom detektorom CMS]]></title_hr><title_en><![CDATA[The Higgs boson properties measurements and search for new physics with the CMS detector]]></title_en><user_id>4052</user_id><user_firstLast_name>Ivica Puljak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-7118</code><acronim><![CDATA[HIGGSPRO]]></acronim><duration>01.10.2014 - 30.09.2018</duration><status>Završio</status><financ_value>123.129,83 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Fakultet elektrotehnike, strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Electrical Engineering, Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>6750, 6374, 6738, 6471, 7133, 7481, 7488, 7495, 7563, 19069, 19070, </team_members_id><team_members_names><![CDATA[Damir Lelas, Nikola Godinović, Ilja Doršner, Željko Antunović, Charlot Claude, Marko Kovač, Roberto Salerno, Ochando Christophe, Sirois Yves, Pedro Miguel Ribeiro Cipriano, Toni Šćulac, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[CMS detector, LHC, Higgs boson, leptoquarks, electron reconstruction]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The discovery of a Higgs boson by the ATLAS and CMS experiments at the LHC has opened a new era for particle physics, namely precision consistency tests of the SM Higgs boson. The proposed project has two main goals: measurement of the SM Higgs boson properties, as the window for the search for new physics beyond the Standard model, and a direct search for new physical phenomena looking for hypothetical particles called leptoquarks. In the first year of project we will explore the data collected by the CMS experiment during 2011 and 2012, while preparing for the LHC Run II, which is expected to start in 2015. Preparation consists of developing and implementing new electron reconstruction, identification and isolation algorithms, which will be used by the whole collaboration when the new data taking starts.  During the second year of the project we will commission and maintain electron reconstruction algorithms, start collecting the data and make first analysis at new energy. During third and fourth year we will explore the data and concentrate to the two main goals of the project: SM Higgs boson properties measurements and search for new physics. ]]></summary_en></project><project>
<id>1667</id><title_hr><![CDATA[Poluvodičke kvantne strukture za napredne sklopove]]></title_hr><title_en><![CDATA[Quantum semiconductor structures for the next generation devices]]></title_en><user_id>627</user_id><user_firstLast_name>Branko Pivac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-6135</code><acronim><![CDATA[QD STRUCTURES]]></acronim><duration>01.06.2014 - 31.05.2018</duration><status>Završio</status><financ_value>88.269,62 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>2639, 1240, 2934, </team_members_id><team_members_names><![CDATA[Pavo Dubček, Goran Kovačević, Jasna Dasović, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[nanoscience, quantum dots, percolation conductivity, tunneling, photoluminescence, scanning probe microscopy, small angle x-ray scattering, modeling,]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The fundamental properties of matter are drastically changed due to quantum effects in nanoscopically confined particles. It presents the essence of nanoscience and hence is a cornerstone for the production of advanced materials and devices. The scope of this project is to explore semiconductor nanoparticles in 0-dim, so called quantum dots (QDs), which are the building blocks for advanced materials. We shall study QDs made of different semiconductors embedded in various dielectric materials. The main intention is to explore many of basic physical properties of such systems which are not clear yet and hence prevent their successful development and application. The several key issues that we shall explore are: a) the process of nucleation and growth of QDs, their self-assembly and self-organization. We shall study experimentally and theoretically nucleation growth and crystallinity of different QDs in various dielectrics, and possibility of superstructures formation. Once formed QDs present several serious challenges. The interface QD/dielectric and/or the structure of dielectric layers close to QDs as well as its impact on optical and electrical properties is still completely obscured. In this respect we shall study radiative and nonradiative recombinations of carriers in this region by PL and TRPL. A special effort will be given to theoretical modelling of interfaces, defect formation on such interfaces modeled with molecular dynamics and attempts to describe the transport properties with such modelling. Finally, electronic properties of such composite material will be explored by transport measurements and compared to several simulation models. Several models of unbiased and biased percolation will be explored and applied to this problem. Finally, formation of metal nanoparticles and their plasmonic effect will be explored and analyzed as a special approach to the light management. ]]></summary_en></project><project>
<id>1669</id><title_hr><![CDATA[Matematičko modeliranje i numeričke simulacije procesa u tankim i poroznim sredinama]]></title_hr><title_en><![CDATA[Mathematical modeling and numerical simulations of processes in thin or porous domains]]></title_en><user_id>1462</user_id><user_firstLast_name>Eduard Marušić-Paloka</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-3955</code><acronim><![CDATA[MaSiMo]]></acronim><duration>01.07.2014 - 30.06.2018</duration><status>Završio</status><financ_value>68.996,45 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>3164, 3683, 3254, 3179, 817, 3663, 3424, 5900, </team_members_id><team_members_names><![CDATA[Mladen Jurak, Josipa Pina Milišić, Ana Žgaljić Keko, Anja Vrbaški, Igor Pažanin, Maja Starčević, Andrijana Ćurković, Marija Prša, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Mathematical modelling,Asymptotic analysis,Numerical simulations,Fluid flow,Homogenization, Boundary layer,Lubrication,Complex fluids,Porous medium]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[We frequently deal with systems described by the differential equations coming from conservation laws that are too complicated to be solved and are of limited use in practice. In many such situations the original physical laws can be replaced by empirical laws or other approximations derived on engineering level of rigor. Mathematical point of view requires justification of those models to see their validity, applicability and accuracy. That can be achieved theoretically by investigating the deviation from the original model, or numerically by comparing simulations with experimental data. Each approach, has its advantages and disadvantages and are, frequently, complementary. In the frame of MaSiMo project we will consider fluid flow through thin domains like pipes and fractures, as well as low permeability domains as porous media.The fluids are either Newtonian or micropolar, monophase or multiphase.  Physical processes in those fluids are convective, diffusive, dispersive or conductive, isothermal  or nonisothermal. Theoretical analysis is based on a priori estimates for governing differential equations, different notions of convergence and compactness. In particular asymptotic analysis and homogenization will be used.  For derivation of a priori estimates a powerful tool is the entropy dissipation method that is considered in this project in the context of nonlinear diffusion and population dynamics problems with a perspective of extension to other considered models. Proposed research is connected to many engineering disciplines, such as mechanical and petroleum engineering, hydrogeology etc. Expected results could improve engineering practice. In Croatian mathematical community  there is a significant  research in this field with several trained scientists. However,  they are dispersed in smaller groups. One of the aims of this project is formation of larger research group with focused scientific interests more competitive in a search for European grants.  ]]></summary_en></project><project>
<id>1672</id><title_hr><![CDATA[Općeslavenski lingvistički atlas (OLA) i Europski lingvistički atlas (ALE)]]></title_hr><title_en><![CDATA[General Slavic Linguistic Atlas (OLA) and European Linguistic Atlas (ALE)]]></title_en><user_id>18899</user_id><user_firstLast_name>Ranko Matasović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-8706</code><acronim><![CDATA[OLAALE]]></acronim><duration>01.09.2014 - 31.10.2018</duration><status>Završio</status><financ_value>72.864,82 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filologija, </scie_field_hr><scie_field_en>Philology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>751, 3723, 818, 787, 3726, 2596, 886, 869, 933, 3624, 2984, 3755, 2997, 3415, 3473, 3583, 3659, 5981, 5988, 6131, 5593, 17864, </team_members_id><team_members_names><![CDATA[Mira Menac-Mihalić, Dunja Brozović Rončević, Anđela Frančić, Anita Celinić, Tijmen Pronk, Silvana Vranić, Boris Kuzmić, Mijo Lončarić, Vesna Zečević, Sonja Wölke, Martina Ireinová, Jadwiga Waniakowa, Walentina Rusak, Pavlo Hrytsenko, Gabriela Núcsková, Petra Pradkova, Jana Villnow Komárková, Goran Filipi, Carmen Kenda-Jež, Dubravka Ivšić, Jožica Škofic, Ivana  Štokov, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[dialectology, linguistic atlas, linguistic maps, slavic languages, european languages]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The “General Slavic Linguistic Atlas” (OLA) and the “European Linguistic Atlas” (ALE) are long-term international linguistic projects. The OLA project involved research material derived from a special survey carried out in 853 settlements, the result of which was an extremely rich dialectological registry. The material collected does not confirm the traditional view of the disintegration of the Proto-Slavic language, instead showing that the disintegration process of the Slavic whole was much more complex. This is seen in isoglosses that cut Slavic territory into the most highly differing directions. This is proof that particular Slavic groups in various historical periods found themselves in complex relationships amongst themselves and that were constantly changing for economic, political, or cultural reasons. Linguistic material for ALE was collected using a special survey carried out in a majority of European countries, including 15 Croatian survey points. The project also involves the etymological and onomasiological interpretation of linguistic material from all European survey points.This project of linguistic atlases provides world dialectology with organised data on the phonetic, phonological, morphological and lexical systems of a large number of languages and dialects, and enables the well-founded study of the linguistic development of European languages. Croatian material is presented and interpreted, and the linguistic relationships between data from the dialects researched is confirmed. Conclusions are drawn on the history and development of languages, on the relationships between them, and thus on the relationships of the Croatian language towards neighbouring and distant dialects. This will provide material for comparative genetic and typological research of linguistic systems in the Slavic and non-Slavic world. These synchronic and diachronic relationships will be presented in the OLA and ALE books and atlases in the form of maps and commentary.]]></summary_en></project><project>
<id>1673</id><title_hr><![CDATA[Pleitropija, genske mreže i putevi u izoliranim ljudskim populacijama: 10.001 Dalmatinac]]></title_hr><title_en><![CDATA[Pleitropy, gene networks and gene pathways in isolated human populations: the 10,001 Dalmatians biobank]]></title_en><user_id>4228</user_id><user_firstLast_name>Ozren Polašek</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-8875</code><acronim><![CDATA[10,001 Dalmatians]]></acronim><duration>01.07.2014 - 30.06.2018</duration><status>Završio</status><financ_value>127.599,71 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Javno zdravstvo i zdravstvena zaštita, </scie_field_hr><scie_field_en>Public health and health services, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Split School of Medicine]]></institution_en><team_members_id>5251, 5405, 5407, 1358, 19117, 17833, </team_members_id><team_members_names><![CDATA[Ana Miljković, Mirna Kirin, Igor Rudan, Ivana Kolčić, Ajka Relja, Andrea Gelemanović, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Genomics, anthropometrics, 3 dimensional, exome, analysis]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[This project will investigate how pleitropy (the effect of one gene on multiple phenotypic traits), gene networks and gene pathways are determining a number of clinically relevant quantitative traits. Primary research focus is on the genetic basis of body shape and facial features, based on an innovative approach to produce large number of measurements from the 3-dimensional body and face scanning. In order to achieve this aim, we will perform 3D scanning of 2,000 healthy subjects from the island of Korcula, within one of the largest biomedical research resources in Croatia – the 10,001 Dalmatians biobank. Besides excellent genotyping and sequencing opportunities, the inclusion of subjects from the isolated island populations facilitates gene discovery and enables the search for the rare genetic variants. After completion of genome-wide association and exome analysis, we will also use gene networking and pathway analysis tools, as well as the advanced analytic tools, such as random forest, lasso regression and partial least squares regression in order to produce results that can be translated to clinical medicine, fitness and beauty, as well as legal medicine and forensics. Progress over the existing research designs will also be achieved by inclusion of extensive confounding information and family structure into analysis. All these findings will also be investigated in follow-up measurements and linked with the morbidity and mortality information in the future, thus further developing a coherent resource capable of producing highly competitive research results. With the excellent track record of the principal investigator, outstanding institutional support and well-established research team experienced in computational genomics and field work, this project will provide a substantial step forward over the existing state-of-the-art studies that rely on simple genomic associations, yet manage to publish their results in the top-end journals. ]]></summary_en></project><project>
<id>1674</id><title_hr><![CDATA[Starosno-ovisna ekspresija membranskih prijenosnika u štakora]]></title_hr><title_en><![CDATA[Aging-related expression of membrane transporters in rat]]></title_en><user_id>179</user_id><user_firstLast_name>Davorka Breljak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-1481</code><acronim><![CDATA[AGEMETAR]]></acronim><duration>01.10.2014 - 31.03.2019</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Institut za medicinska istraživanja i medicinu rada]]></institution_hr><institution_en><![CDATA[Institute for Medical Research and Occupational Health]]></institution_en><team_members_id>200, 226, 951, 221, 128, 216, 201, 343, 1099, 87, 171, 1396, 19039, 126, </team_members_id><team_members_names><![CDATA[Marija Ljubojević, Ivana Vrhovac, Dean Karaica, Vedran Micek, Jasna Jurasović, Tatjana Orct, Maja Peraica, Dubravka Rašić, Ivana Novak Jovanović, Goran Gajski, Marko Gerić, Ivica Rubelj, Lucia Nanić, Ivan Sabolić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[aging, antioxidants, drug transporters, hepatotoxicity, liver, kidney, Klotho, membrane transporters, nephrotoxicity, oxidative stress,  telomeres ]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Aging is a physiological process characterized by a gradual decline in physical fitness and other functional capabilities. The mechanisms of aging and possible actions of slowing down or ameliorating aging-related processes are poorly understood. In humans, one of the characteristics of old age is polypharmacy, which elevates risks of drug-drug interactions and drug-induced adverse reactions and organ toxicity, such as hepatotoxicity and nephrotoxicity. These reactions may partially result from diminished drug metabolism and/or mainly from impaired activity/expression of various membrane transporters that are responsible for drug excretion in liver and kidneys. These both mechanisms have been poorly studied in senescent organs. Here we promote a hypothesis that the aging-induced oxidative stress, known to downregulate the activity/expression of the aging suppressor gene (Klotho) and to shorten the length of telomeres, also diminishes the activity/expression of various membrane transporters in liver and kidneys, and that these changes can be ameliorated by treating animals with antioxidants resveratrol and melatonin. The extent and the intensity of aging-related changes, and the beneficial effects of antioxidants may be sex-related. To test this hypothesis, we propose various biochemical and cell- and molecular-biological studies of aging parameters and aging-dependent expression of various membrane transporters in the mammalian liver and kidneys using a rat model of experimental aging. Possible aging-related decline in the expression of these transporters may explain a higher incidence (women > man) of drug interactions and toxicity in old people. The studies will define the underlying cellular mechanisms that contribute to generation of the aging-related pathophysiological conditions in the liver and kidneys, and will indicate possible ways of their amelioration. Positive results may point to remedies to be used for improving the health of elderly people.]]></summary_en></project><project>
<id>1680</id><title_hr><![CDATA[Ekološki pristup projektiranju broda i optimalnom planiranju rute]]></title_hr><title_en><![CDATA[Greener Approach to Ship Design and Optimal Route Planning]]></title_en><user_id>4256</user_id><user_firstLast_name>Jasna Prpić-Oršić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-8722</code><acronim><![CDATA[GASDORP]]></acronim><duration>20.07.2014 - 19.07.2018</duration><status>Završio</status><financ_value>131.926,47 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Brodogradnja, </scie_field_hr><scie_field_en>Naval architecture, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Tehnički fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Engineering]]></institution_en><team_members_id>4179, 3868, 2951, 4580, 4658, 4890, 5599, 5931, 5403, 19041, </team_members_id><team_members_names><![CDATA[Duško Pavletić, Tomislav Mrakovčić, Marko Valčić, Roko Dejhalla, Dunja Matulja, Odd Magnus Faltinsen, Ozren Bukovac, Nikola Račić, Igor Rudan, Natalija Vitali, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[seakeeping, ship speed, ship resistance, ship propulsion, fuel consumption, GHG emission, weather routing]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The accurate calculation of attainable ship speed at actual sea is essential from economical and also environmental aspects. Reliable ship speed loss estimation under real environmental conditions allows a more accurate prediction of the power increase and fuel consumption as well as gas emissions from ships. Nowadays this second issue becomes very important because of the problem of global warming. Following the increasing awareness of the environmental and human health concerns of shipping, legislative actions have been taken on global and national levels making mandatory (from January 1st 2013) that new ships over 400 gross tonnage, to comply with the regulations, should have emissions of CO2 under limiting value. Technological enhancement to ships like improved hull designs as well as improvement in power and propulsion systems could potentially reduce CO2 emission up to 35 %. These measures could effectively be combined with several other operational measures, such as weather routing and voyage planning, in order to ensure that fuel consumption and CO2 emissions from ships are minimized on every voyage.The proposed research will be conducted in three main areas: 1. Improvement of the methodology of ship speed, fuel consumption and greenhouse gases (GHG) emissions (especially CO2) calculation on actual weather conditions, 2. Optimization of the ship hull (bow and stern) and ship propulsion system operating in actual weather condition, 3. Optimization of ship route by taking into account all relevant parameters: weather prediction, attainable ship speed on waves, main engine performance and navigation constrains. The objective is to improve ship design and performance taking into accounts the environmental issue, creating a so called eco-efficient or “green” ship design. The project team consists of the scientists who are experts in the naval architecture, mechanical engineering and marine engineering field which allow solving this problem multidisciplinary. ]]></summary_en></project><project>
<id>1682</id><title_hr><![CDATA[Genetska osnova količne bioaktivnih hranivih tvari hrvatskih populacija graha]]></title_hr><title_en><![CDATA[Genetic basis of bioactive nutrient content in Croatian common bean landraces]]></title_en><user_id>1294</user_id><user_firstLast_name>Klaudija Carović-Stanko</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2013-11</proposal_call><code>UIP-2013-11-3290</code><acronim><![CDATA[BeanQual]]></acronim><duration>16.06.2014 - 15.06.2017</duration><status>Završio</status><financ_value>121.674,44 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Agronomski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Agriculture]]></institution_en><team_members_id>770, 6287, 3338, 4953, 5513, 5829, 4927, 4954, 3037, 17838, 12601, </team_members_id><team_members_names><![CDATA[Zlatko Liber, Jerko Gunjača, Mirjana Herak Ćustić, Marko Petek, Martina Grdiša, Ivan Radosavljević, Tomislav  Karažija, Boris Lazarević, Igor Palčić, Monika Vidak, Ana Barešić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Phaseolus vulgaris L., nutrients, bioactive substances, molecular markers, genetic diversity, association mapping]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Common bean is a valuable legume for human consumption worldwide, being an important source of proteins, vitamins and minerals with considerable potential as a functional food. However, the increased mineral content in the diet does not guarantee increased mineral status for consumers and consequently mineral malnutrition is one of the global health concerns. Phytic acid (PA) acts as antinutritive compound by binding mineral cations and forming mixed salts. PA is also the main storage molecule for phosphorus and it is essential for normal seed development and germination. Seed mineral and PA content varies widely among bean genotypes. In Croatia bean is traditionally grown in low input production systems. The production is based on landraces which are adapted to local environments and display high levels of morphological diversity. A broad variability is also expected in seed bioactive nutrient content as well as on genetic level. Through international collaboration on Phaseolus genomics, a lot of information has become available including genetic linkage maps, microsatellite databases and a massive number of single nucleotide polymorphisms (SNP) sequences. In proposed project an integrated approach will be used to characterize bioactive nutrient variability and the inherent genetic diversity. In conjunction with a detailed data on bioactive nutrient content, a whole genome association mapping analysis will be carried out in order to identify quantitative trait loci (QTLs) related to bioactive nutrient content. Success in bean breeding for higher quality relies on the availability of information on bioactive nutrient content and the knowledge of genetic bases of quality trait variability. The integration of fundamental (molecular genetics) and applied (plant nutrition, plant breeding) sciences will facilitate the management of traditional landraces as sources of bioactive nutrients in future breeding programs based on marker-assisted selection (MAS).]]></summary_en></project><project>
<id>1683</id><title_hr><![CDATA[Rekonstrukcija okoliša u Hrvatskoj tijekom kvartara primjenom izotopnih metoda]]></title_hr><title_en><![CDATA[Reconstruction of the Quaternary environment in Croatia using isotope methods]]></title_en><user_id>1168</user_id><user_firstLast_name>Ines KRAJCAR BRONIĆ</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-1623</code><acronim><![CDATA[REQUENCRIM]]></acronim><duration>01.09.2014 - 30.11.2018</duration><status>Završio</status><financ_value>132.676,06 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Geologija, </scie_field_hr><scie_field_en>Geology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>353, 3702, 3367, 1159, 1343, 1413, 3789, 1324, 3115, 3097, 4142, </team_members_id><team_members_names><![CDATA[Nada Horvatinčić, Tatjana Bakran-Petricioli, Sanja Faivre, Jadranka Barešić, Maša Surić, Neven  Bočić, Andreja Sironić, Robert Lončarić, Nenad Buzjak, Nina Lončar, Iva Babić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[paleoclimate, paleoenvironment, Quaternary, speleothem, algal rim, tufa, lake sediment, stable isotopes, 14C dating, U-Th series dating]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Interdisciplinary scientific study of paleoclimate and paleoenvironment is of the great importance for prediction of future climate and environmental changes. Croatia occupies a key position between eastern and western Mediterranean basins and delimits central European and the Mediterranean regions influenced by different climates. Dinaric karst, covering half of the Croatian territory, offers exquisite potential for such a research, having the wide range of karstic forms already proven as good (paleo)environmental archives, such as terrestrial and submerged speleothems, tufa deposits and lake sediments in karstic lakes and marine algal rims in the coastal area. Within this research various carbonate sediments from different climate zones will be studied: speleothems from 3 locations in littoral Croatia, mountainous Gorski Kotar region and central Croatia, lake sediments from Plitvice Lakes, tufa deposits from Zrmanja River, and marine algal rims from ~8 locations along the eastern Adriatic coast. Research will be based on isotopic methods that include analyses of stable isotope ratios 13C/12C and 18O/16O in carbonate deposits, 2H/1H and 18O/16O in water, and radioactive isotopes 14C and U-Th series for dating. Stable isotopes in carbonates will provide information about past environmental conditions, temperature variations, lake evaporation, bioactivity and productivity, and indicate the origin of carbon and mechanisms of calcite precipitation. Algal rims serve as good and precise sea-level indicators and additionally their morphology, age and stable isotope composition could be directly linked to climate changes.The expected outcome is the estimation of regional response of the environment in Croatia to global changes during the Quaternary, and of differences in response of various carbonates to paleoenvironmental changes and their correlations.The project combines groups from Ruđer Bošković Institute, Faculty of Science (Univ. of Zagreb), and University of Zadar.]]></summary_en></project><project>
<id>1687</id><title_hr><![CDATA[Zaštita privatnosti deidentifikacijom u nadzornim sustavima ]]></title_hr><title_en><![CDATA[De-identification for Privacy Protection in Surveillance Systems  ]]></title_en><user_id>4290</user_id><user_firstLast_name>Slobodan Ribarić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-6733</code><acronim><![CDATA[DePPSS]]></acronim><duration>01.10.2014 - 30.09.2018</duration><status>Završio</status><financ_value>81.633,69 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>4689, 4593, 20381, 20383, 4584, </team_members_id><team_members_names><![CDATA[Branko Samaržija, Marijo Maračić, Vitomir  Štruc, Darko Mihalić, Darijan Marčetić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[privacy protection, biometric identification, de-identification, surveillance systems, video ]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Owing to advances of video surveillance systems it is possible, besides detection of people&#39;s behavioural anomalies, by using of reliable recognition software to perform identification and simultaneously trace people in the real time. Whilst it is recognized that there are justified reasons for acquisition and sharing videos in manners such as security, bio-terrorism surveillance applications, low enforcement and forensics, there is also a strong need for protecting the privacy of the guiltless individuals who are inevitably captured in the recordings. Video surveillance is privacy intrusive because it allows the observation of certain information that is considered privacy intrusive. Face has central role in the process of human recognition and identification in videos, thus the special attention has to be devoted to the face de-identification methods for privacy protection. De-identification addresses, in context of our project, the automated methods of concealing or/and removing face identifiers of individuals captured in videos. The importance of privacy protection is mirrored in documents such as UN Universal Declaration of Human Rights, and EU’s Data Protection Directive (95/46/EC) as well as commissioned review of the Data Protection Directive (95/46/EC) by the EU Information Commissioner’s Office from July 2008. The general public has become increasingly aware of the potential danger for their personal data to be abused.Beside scientific objectives and goals (robust face localization, novel methods for face de-identification in videos, preserving data utility and naturalness in de-identification videos, privacy protection), the main objectives of the proposed project are human resources (early stage researchers and PhD students) development by transfer of knowledge in the fields of advanced technologies to carry out problem-oriented research, and increasing a competitiveness level of the research team for Horizon 2020 project applications. ]]></summary_en></project><project>
<id>1690</id><title_hr><![CDATA[Klasifikacija i objašnjenja antisocijalnog poremećaja osobnosti i moralna i kaznena odgovornost u kontekstu Hrvatskog zakona o mentalnom zdravlju i skrbi]]></title_hr><title_en><![CDATA[Classification and explanations of antisocial personality disorders and moral and criminal liability within the context of Croatian mental health law and care]]></title_en><user_id>4121</user_id><user_firstLast_name>Luca Malatesti</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-8071</code><acronim><![CDATA[CEASCRO]]></acronim><duration>01.09.2014 - 31.08.2018</duration><status>Završio</status><financ_value>42.232,40 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filozofija, </scie_field_hr><scie_field_en>Philosophy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Filozofski fakultet u Rijeci]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>2985, 4704, 4172, 3788, 4815, 6425, 7394, 7077, 4401, 2875, 22814, </team_members_id><team_members_names><![CDATA[Vesna  Šendula Jengić, Predrag Šustar, Marko Jurjako, Zdenka Brzović, John McMillan, Filip Čeč, Mariastella  Pulvirenti, Vanni D&amp;#39;Alessio, Jelena Hodak, Dalida Rittossa, Karge Heike, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[antisocial personality disorders, psychiatric classification,  psychiatric explanation, moral responsibility,  Croatian mental health law and care]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[This interdisciplinary project investigates the problem of the social response in Croatia to a class of offenders classified as having antisocial personality disorders. The core methodology consists in  conducting philosophical investigations that are aimed at offering practical recommendations and that are constrained by knowledge of the practical setting of Croatian mental health law and care.  Two central philosophical issues appear to be relevant to the philosophical investigation and, thus, addressing them  is the aim of the project. First, a significant part of the contemporary debate on the social response to antisocial personality disorder centers on this notion. Some have argued that this notion involves normative preconceptions  against the liberties of certain individuals. Others have questioned the accuracy and scientific robustness of the diagnosis of antisocial personality disorders and its precision of related risk predictions.  Second, the justification for choosing the appropriate treatment for people with antisocial personality disorder must also be a moral one. In particular, a relevant type of moral justification has to be grounded in principles that correlate psychological descriptions and explanations of a person’s behavior with his or her degree of responsibility.  Similarly, compulsory treatment appears to be conditional upon a person’s diminished responsibility or capacity to act accordingly to a treatment decision, together with the existence of a risk to themselves or to others.The philosophical investigation of the project will be integrated with the contributions of  a leading forensic psychiatrist in Croatia, a sociological qualitative analysis of the practices and challenges that are encountered by institutional representatives in the forensic department of the Rab psychiatric hospital and an historical investigation of the institutional response to antisocial personality disorder in the region in the period 1918-1980.]]></summary_en></project><project>
<id>1697</id><title_hr><![CDATA[Održiva proizvodnja bioetanola i biokemikalija iz otpadnih poljoprivrednih lignoceluloznih sirovina]]></title_hr><title_en><![CDATA[Sustainable production of bioethanol and biochemicals from agricultural waste lignocellulosic raw materials ]]></title_en><user_id>4332</user_id><user_firstLast_name>Božidar Šantek</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-9158</code><acronim><![CDATA[SPECH-LRM]]></acronim><duration>01.09.2014 - 31.08.2018</duration><status>Završio</status><financ_value>127.413,90 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Biotehnologija, </scie_field_hr><scie_field_en>Biotechnology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Food Technology and Biotechnology]]></institution_en><team_members_id>5761, 5778, 5039, 4314, 3709, 4912, 6032, 450, 4102, 4098, 4100, 4321, 4324, 5414, 4450, 4544, 4437, 4438, 4430, 17840, 23620, </team_members_id><team_members_names><![CDATA[Predrag Horvat, Srđan Novak, Vesna  Zechner-Krpan, Anita Slavica, Vlatka Petravić Tominac, Sunčica Beluhan, Mirela Ivančić Šantek, Tonči Rezić, Mladen Pavlečić, Antonija Trontel, Mario Novak, Ivan-Krešimir Svetec, Anamarija Štafa, Marina Miklenić, Bojan Žunar, Draženka Komes, Ana Belščak-Cvitanović, Aleksandra  Vojvodić, Arijana Bušić, Martina Andlar, Nenad Marđetko, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[bioetahnol, lactic acid, physiological active oligosaccharides, lignocellulosic raw materials, integrated bioprocess, mathematical modeling, LCA]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The aim of this project proposal is the development of sustainable bioprocesses for the production of bioethanol and biochemicals [lactic acid (LA) and physiologically active oligosaccharides (PAO)] from agricultural waste lignocellulosic raw materials (e.g. wheat straw, corn stover and cob, onion peels, cocoa husks, pea pods, walnut shells and sugar beet pulp). All these agricultural byproducts are abundant, cheap, non-food competing and renewable polysaccharide-based feedstocks.  In this project, agricultural waste lignocellulosic raw materials will be hydrolyzed by thermal, chemical or enzymatic methods or their combinations in order to obtain adequate disintegration of raw materials. Studies of bioethanol and LA production will be performed by the semi-solid or solid state fermentation in the new constructed horizontal rotating tubular bioreactor (HRTB). The most suitable microorganisms for bioetahnol and LA production will be identified and improved by genetic methods. Studies regarding suitable purification methods for all three bio-products will be performed in order to obtain pure compounds for theirs further practical use. Integration between production and separation bioprocess stages will be also examined in order to improve ecological and economical aspects of these bioprocesses. The sustainability of bioethanol and LA production will be evaluated through the realization of Life Cycle Assessment (LCA). The most efficient and sustainable bioprocess configuration will be determined and consequently scale-up procedure will be proposed. The scale-up procedure will be based on the developed integral bioprocess mathematical model and other scale-up criteria. Project outcomes will be new integrated bioprocesses for the transformation of agricultural waste lignocellulosic raw materials into high added value products.]]></summary_en></project><project>
<id>1699</id><title_hr><![CDATA[Klima jadranske regije u njenom globalnom kontekstu]]></title_hr><title_en><![CDATA[Climate of the Adriatic REgion in its global context]]></title_en><user_id>3375</user_id><user_firstLast_name>Mirko Orlić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-2831</code><acronim><![CDATA[CARE]]></acronim><duration>01.07.2014 - 30.06.2018</duration><status>Završio</status><financ_value>116.291,72 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Geofizika, </scie_field_hr><scie_field_en>Geophysics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>4069, 2552, 2840, 1265, 2650, 1315, 2898, 1417, 2655, 2635, 1121, 3146, 2839, </team_members_id><team_members_names><![CDATA[Čedomir Branković, Ksenija Cindrić, Marjana Gajić-Čapka, Ivan Güttler, Ivana Herceg Bulić, Iva Međugorac, Miroslava Pasarić, Zoran Pasarić, Mirta Patarčić, Melita Perčec Tadić, Renata Sokol Jurković, Lidija Srnec, Ksenija Zaninović, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Adriatic, climate change, extremes, climate models, downscaling, spatial interpolation, sea-level trend, coastal flooding, sea-level projections]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Temporal and spatial statistical analysis of climatological variables will be performed, with the emphasis on the multidecadal changes in temperature and precipitation indices of extremes in the Adriatic region. Particular attention will be paid to the analysis of drought, floods and heat waves. Possible change in climate suitability for tourism will be investigated. The obtained gridded fields will become a reference data for the validation of climate models and an input into the flash-flood warning systems. Current and future climate of the Mediterranean area will be examined by analyzing the results of global-model simulations and by using the statistical and dynamical downscaling approach. Simulations by RegCM4.2 regional climate model will be performed at the horizontal resolution of 12.5 km. Also planned is to utilize results from experiments based on coupled atmosphere-ocean models from the currently running Med-CORDEX project with a purpose of analyzing the contribution of oceanic component in the simulations over the Adriatic Sea and the surrounding land area. Trends and interdecadal variability of sea level in the Mediterranean sub-basins will be identified and contributions of the governing processes will be assessed. Coastal flooding in the Northern Adriatic and time evolution in occurrence of extreme sea levels in the context of mean-sea-level rise will be considered. Finally, older variants of semi-empirical method of projecting global sea level will be compared with the more general method recently developed. It is expected that the project thus considered will meet the three important criteria (relevance, reliability, feasibility), by addressing one of the few priorities put forward by the European Union in its growth strategy Europe 2020, by relying on the state-of-the-art methods of data analysis and modeling, and by involving a majority of researchers engaged in the study of climate-related physical processes in Croatia.]]></summary_en></project><project>
<id>1703</id><title_hr><![CDATA[Jako korelirani elektroni u slojnim organskim materijalima i manganitima: niskofrekventna pobuđenja i nelinearna dinamika]]></title_hr><title_en><![CDATA[Strongly  Correlated Electrons in Layered Organics and Manganites: Low Frequency Excitations and Non-linear Dynamics]]></title_en><user_id>2680</user_id><user_firstLast_name>Silvia Tomić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-1011</code><acronim><![CDATA[SCEinLOM]]></acronim><duration>01.06.2014 - 31.07.2018</duration><status>Završio</status><financ_value>128.316,98 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut za fiziku]]></institution_hr><institution_en><![CDATA[Institute of Physics in Zagreb]]></institution_en><team_members_id>1433, 2708, 2752, 3073, 3184, 2842, 3352, 17776, 21185, </team_members_id><team_members_names><![CDATA[Amir Hamzić, Mario Basletić, Emil Tafra, Bojana Hamzić, Tomislav Ivek, Matija Čulo, Marko Pinterić, Branimir Mihaljević, David Rivas Góngra, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[correlated electrons, unconventional superconductivity, colossal magnetoresistance, charge and spin orderings, quantum spin liquids, nonlinear effects]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Strongly correlated electrons in solids generate broken symmetry phases and collective excitations that are fundamental to our understanding of the most intriguing properties of quantum matter. Phase diagrams of layered cuprate, organic superconductors and manganites, as well as some other transition-metal systems, famous for the phenomena of unconventional superconductivity (SC) and colossal magnetoresistance (CMR), respectively feature an extraordinary complexity of electronic phases, which can be tuned by chemical composition, magnetic field and pressure. A prominent place among these phases is held by stripes, patterns of charge order (CO), which are thought to be linked to SC and CMR, as well as by CO phases with ferroelectric signatures due to a rich variety of nonlinear properties and complex dynamics. Despite intense research efforts, these basic issues in condensed matter physics bear many open questions. We propose to investigate the nature of charge/spin-ordered phases and their motion developed in series of organic and transition metal solids applying modern experimental tools available at the Institute of Physics, Zagreb and at the Department of Physics, Faculty of Science, University of Zagreb (dielectric spectroscopy, pulsed nonlinear conductivity, ac/dc resistance, magnetoresistance and Hall effect).  Our overall contributions to the field and our expertise in condensed matter physics have been internationally recognized. Together with the available experimental means, this positions us as researchers fully suitable and competent for the proposed task. Our international partners will give an added value with samples, experiments and expertise in the terahertz and infrared spectroscopy. Integrated students and postdocs are going to acquire advanced skills in the materials science and learn to solve complex problems in a collaborative environment. Results will be published in international scientific journals and presented at international conferences.]]></summary_en></project><project>
<id>1706</id><title_hr><![CDATA[Kruženje sumpora i ugljika u morskom i slatkovodnom okolišu]]></title_hr><title_en><![CDATA[The Sulphur and Carbon Dynamics in the Sea- and Fresh-Water Environment]]></title_en><user_id>287</user_id><user_firstLast_name>Irena  Ciglenečki-Jušić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-1205</code><acronim><![CDATA[SPHERE]]></acronim><duration>01.09.2014 - 31.08.2018</duration><status>Završio</status><financ_value>128.920,89 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>561, 989, 454, 290, 278, 1155, 84, 17873, </team_members_id><team_members_names><![CDATA[Elvira Bura-Nakić, Nevenka Mikac, Palma  Orlović-Leko, Marija Marguš, Milan Čanković, Jelena Dautović, sanja frka milosavljević, Ana  Cvitešić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[sulphur speciation, organic matter properties, nanoparticles in water environment, aerosols, global climate changes, extreme events, euxinia  ]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The SPHERE aims to study sulphur (S) and carbon (C) dynamics between different environmental compartments (atmosphere, water, sediment, biota) of the sea- and fresh-water environment including distribution between organic, inorganic, dissolved, colloidal and nanoparticulate fractions. S and C cycles in the aqueous environment are recognized as important factors for regulating global climate. Nowadays, human activities have vastly affected the S and C cycles. The aquatic ecosystem responses to likely changes in physical, chemical and socio-economic forcing induced by global climate changes, including warming, acidification, biodiversity modifications as well changes in frequency of extreme events (flooding, dust input, hypoxia-anoxia appearance) and by growing anthropogenic pressures will be considered under SPHERE. Effects of the main natural and anthropogenic forcing (extreme events, eutrophication, global changes) related with S and C dynamics will be studied.The SPHERE objectives are: 1) testing and improving existing methods and development of new methods essential for S and organic matter (OM) characterization in water and atmospheric environment; 2) to estimate exchanges and interactions of S and C with other natural and potentially toxic trace elements within and between the major environmental compartments; 3) to monitor and couple S and C dynamics under extreme events (stratification-destratification, hypoxia-anoxia, extreme atmospheric inputs); 4) to synthesize all obtained data for assessment of ecosystem vulnerability and ecological status, in line with water framework directive and national strategy. The SPHERE will be implemented in the period of 4 years through 5 workpackages: 1) OM properties and dynamics; 2) S speciation and dynamic; 3) S, C interaction with trace metals and importance of chalcogenide nanoparticles; 4) thermodynamic predictions for S and C distribution and dynamics; 5) project management.]]></summary_en></project><project>
<id>1715</id><title_hr><![CDATA[Primjena matematičkog modeliranja i inteligentnih algoritama pri konstrukciji odjeće]]></title_hr><title_en><![CDATA[Application of mathematical modelling and intelligent algorithms in clothing construction]]></title_en><user_id>42</user_id><user_firstLast_name>Tomislav Rolich</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-3011</code><acronim><![CDATA[AMMIACC]]></acronim><duration>01.10.2014 - 30.09.2018</duration><status>Završio</status><financ_value>54.801,25 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Tekstilno-tehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Textile Technology]]></institution_en><team_members_id>4302, 1095, 5086, 7420, 4325, </team_members_id><team_members_names><![CDATA[Slavica  Bogović, Daniel Domović, Jacqueline Domjanic, Zoran Stjepanovič, Slavenka Petrak, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[intelligent algorithms, mathematical modelling, packaging, optimization, automatic marker-making, clothing construction, geometric morphometry]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[In the project it is intended to develop new computer programs based on mathematical modelling and intelligent algorithms. Scope of computer programs is an area of clothing construction, and therefore data from measurements and scanning using 3D body scanners will be collected. For the analysis of digitized data of human body, data acquisition of static and dynamic anthropometry will be collected and then processed with geometric morphometry and PCA methods. In that way data of shapes and sizes that cannot be acquired with the usual methods of measurement and data processing will be obtained. Based on these data new methods of construction will be developed, for which the most applicable methods of mathematical modelling will be defined. Intelligent algorithms will be used for solving problems related to the automatic marker making, where solutions to specific problems and conditions that must be met for that purpose will be found.Using distinctive interdisciplinary approach computer programs will be developed for the purpose of construction of specific garment that is not common in our market such as overalls for professional sports, diving suits or clothes that is used for medical purposes (compression garments, etc.), and protective clothing. The development of software applications will be based on scientific knowledge, and it also can have its practical application in the manufacture of clothing. In cooperation with industry, garments could be developed that are not in everyday use and for which there is a need in the domestic and foreign markets.]]></summary_en></project><project>
<id>1716</id><title_hr><![CDATA[Nekovalentne interakcije u dizajnu novih fotoosjetljivih molekula]]></title_hr><title_en><![CDATA[Non-covalent interactions in design of novel photosensitive molecules ]]></title_en><user_id>243</user_id><user_firstLast_name>Davor Margetić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-9310</code><acronim><![CDATA[NoncoPhoto]]></acronim><duration>01.09.2014 - 31.08.2018</duration><status>Završio</status><financ_value>122.863,28 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>3939, 368, 4851, 566, 963, 17759, </team_members_id><team_members_names><![CDATA[Vjekoslav Štrukil, Zoran Glasovac, Anamarija Briš, Ivana Antol, Tomislav Portada, Mateja Đud, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[physical-organic chemistry, green chemistry, synthesis, computational chemistry, organic materials]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Project addresses two key research objectives in the European Union: energy and environment conservation. The scientific approach is based on a combination of theoretical and experimental knowledge and experience of collaborators, and includes quantum-chemical calculations and molecular modelling in the molecular design, chemical synthesis and physico-chemical characterisation of molecules.The aim of project is to study fundamental physico-chemical properties of supramolecular systems built by non-covalent interactions (NC) - hydrogen bonding and metal-ligand coordination. The objectives are: a) Synthesis and structural characterization of functionalized bis-chromophoric molecular systems possessing guanidine, (thio)urea and carboxylate functionalities by employment of novel environmentally friendly synthetic methods; b) Detailed insight into the fundamental mechanisms how NC bonds mediate excited energy-transfer processes from one chromophore to another within assemblies; c) Analysis of influence of guanidine and (thio)urea functionalities and their anion complexation on the spectroscopic properties; d) Study of novel assemblies based on NC interactions and influence of different media; e) Development of model heterogeneous photo-responsive catalysis materials; f) Construction of complex multichromophoric supramolecular assemblies.Results of fundamental studies carried out within this project will enrich the understanding of physico-chemical factors in electron transfer processes in supramolecular systems constructed of chromophoric pairs employing the non-covalent bonding. Expected results will enable design of novel photoactive systems which could be applied in the technological development including sensors, fluorescent probes in biomedicine, organic photovoltaics, molecular electronics and heterogeneous catalysis.]]></summary_en></project><project>
<id>1718</id><title_hr><![CDATA[Nuklearna struktura i reakcije: eksperimentima prema neutronskoj liniji kapanja]]></title_hr><title_en><![CDATA[Nuclear structure and reactions – experiments towards the neutron drip line ]]></title_en><user_id>166</user_id><user_firstLast_name>Suzana Szilner</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-7194</code><acronim><![CDATA[SR-ETNo]]></acronim><duration>01.09.2014 - 31.10.2018</duration><status>Završio</status><financ_value>126.651,11 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>193, 257, 4019, 414, 185, 255, 163, 24613, </team_members_id><team_members_names><![CDATA[Deša Jelavić Malenica, Tea Mijatović, Matko Milin, Neven Soić, Milivoj Uroić, Mile Zadro, Igor Gašparić, Romana Popočovski, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[nuclear structure, nuclear reactions, neutron-rich nuclei, nucleon-nucleon correlations, nuclear pairing, nuclear clustering]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Understanding of atomic nuclei relies on knowledge about interaction between their components and details of their relationship. Recent advent of detector arrays allows systematic studies of nuclei away from the region of nuclear stability. With the proper selection of colliding systems and reaction energies, the exchange of nucleons can lead to the population of neutron-rich nuclei, peculiar systems having challenging aspects in their nuclear structure behaviour. The main objective of this research project is to advance understanding of the nuclear reactions and structure in the vicinity of the neutron drip line. By the use of the new generation instrumentation, we will experimentally study three different neutron-rich groups of nuclei: very heavy nuclei (difficult to access experimentally with other methods), medium-mass nuclei (where well known magic numbers disappear), and finally, lower mass nuclei (were the neutron drip line has already been experimentally reached). The major part of the proposed experimental work will be performed at the top international accelerator facilities, but in the well suited cases, the measurements will be performed at the RBI accelerator. The new experimental data will significantly improve our understanding of nuclei far from the stability line and will have a considerable impact on the reaction measurements at next generation of the radioactive beam facilities. Scientists involved in this project are active members of a number of  leading international collaborations in the field, with large experience in experimental research and considerable international reputation. Project PI has remarkable research track record and has led a successful project before. Senior scientists on the project have led a number of competitive projects (funded by MSES, FP7, ESF and Croatian SF). Finally, this project is well integrated with the strategic community document Long Range Plan of the Nuclear Physics European Collaboration Committee.]]></summary_en></project><project>
<id>1721</id><title_hr><![CDATA[Poslovna i osobna insolventnost - putevi izlaska iz prezaduženosti]]></title_hr><title_en><![CDATA[Business and Personal Insolvency - the Ways to Overcome Excessive Indebtedness]]></title_en><user_id>4238</user_id><user_firstLast_name>Mira Dimitrić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-6558</code><acronim><![CDATA[BPII]]></acronim><duration>01.07.2014 - 30.06.2018</duration><status>Završio</status><financ_value>39.576,61 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, </scie_field_hr><scie_field_en>Economy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Ekonomski fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Economics and Business]]></institution_en><team_members_id>4370, 6745, 5495, 5884, 2915, 5117, 5618, 5867, 6706, 5536, 17867, </team_members_id><team_members_names><![CDATA[Ivana Tomas Žiković, Dunja Škalamera-Alilović, Andrea Arbula Blecich, Tomislav Ćorić, Saša Žiković, Dejan Bodul, Branka Crnković-Stumpf, Predrag Bejaković, Jana Katunar, Nikolina Dukić, Sonja Brlečić Valčić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Business Insolvency, Personal Insolvency, Indebtedness, Bankruptcy Law, Restructuring]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Project proposal targets the vital problem of contemporary economic reality and science: insolvency and excessive indebtedness. The goal is to shed light and to interconnect different views of the problem, therefore deepening the understanding of the subject area, and offer preventive and curative solutions. This is necessary because insolvency, on business level, disables development and adequate business and financial restructuring, on personal level it destroys an individual and a family, whereas at social level it creates poverty and enhances negative economic trends. Goals are aimed at: different levels of the principal groups of insolvency and over-indebtedness actors, which are: business, personal and public level, and at business environment as a platform for finding better indebtedness management possibilities. The results of the business level research should significantly improve the prediction possibilities of financial distress and enable larger time-opportunity-window to exploit different restructuring options. Also, the results should provide the scientific knowledge of such financial management that would encourage business development by financial leverage and not threaten the survival of business entities because of the inadequate capital structure. The results of the personal level research should make way to the widespread alteration of approach to new debt. New personal finance culture pattern is expected to be backed by these results and should emerge both among individuals (as demand force of debt), and financial institutions (as supply force of debt). Project proposal is directed toward the research of four distinctive segments of business environment, predominantly of political – legal or economic origin: personal insolvency regulation, business insolvency regulation, monetary and fiscal possibilities in overcoming excessive indebtedness, and banks and financial industry in generating anticipative consumption causing excessive indebtedness.]]></summary_en></project><project>
<id>1722</id><title_hr><![CDATA[Modeli i metode upravljanja inovacijama u razvoju kompleksnih inženjerskih sustava]]></title_hr><title_en><![CDATA[Models and Methods of Innovation Management in Complex Engineering Systems Development]]></title_en><user_id>4471</user_id><user_firstLast_name>Mario Štorga</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-6430</code><acronim><![CDATA[MInMED]]></acronim><duration>01.10.2014 - 30.09.2018</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, </scie_field_hr><scie_field_en>Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>6397, 6393, 19022, 17795, 20038, 19667, </team_members_id><team_members_names><![CDATA[Stanko Škec, Dorian Marjanović, Tomislav Martinec, Marija Majda Perišić, Vladimir Smojver, Jasmin Juranić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[innovation dynamics, knowledge management , socio-technical systems, complex networks, engineering systems development]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The goal of the proposed research project is to develop a set of fundamental models and methods for innovation management within and across hierarchical social networks exiting in contemporary private and public R&D organisations, and to explore and develop analyse and simulation tools for quantifying knowledge and information dynamics as a mean for prediction of the future trends in organisational innovation. The context of the socio-technological framework that transcends the organisational innovation dynamics within contemporary engineering systems and services life-cycle requires the research overriding commitment to methodological pluralism. The integrated analyse – evaluate - create – refine - validate approach will be used as research methodology.The research will build on state of the art developments in the exploration of principles of knowledge management for R&D organisations and will go further; in that it will seek to incorporate the insights from modelling, simulation and visualisation of the complex social, natural and technical systems to the knowledge and information dynamics that encompass the generation, storage, dissemination, filtering, and reprocessing of innovation across hierarchical socio-technological networks. The research effort will entail the development of concepts, theories, metrics and case studies related to the R&D organisational innovation management. The controlled experiments in real-world private and public R&D organisations will be used in research to gain valuable insights across different sectors (automotive, aerospace, energy, transportation, healthcare, public administration, etc.).It is expected that the results of the proposed research will provide valuable interdisciplinary contributions and improve overall understanding respective to the organisational innovation.]]></summary_en></project><project>
<id>1738</id><title_hr><![CDATA[Promjene u kristaliničnim materijalima izazvane ionskim snopovima MeV-skih energija]]></title_hr><title_en><![CDATA[MeV Ion Beam Induced Changes in Crystaline Materials]]></title_en><user_id>4589</user_id><user_firstLast_name>Stjepko Fazinić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-8127</code><acronim><![CDATA[MIOBICC]]></acronim><duration>15.06.2014 - 14.11.2018</duration><status>Završio</status><financ_value>107.588,26 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>4629, 5437, 4893, 4670, 5686, 5793, 4976, 5947, 21267, 19583, 24631, </team_members_id><team_members_names><![CDATA[Milko Jakšić, Ettore Vittone, Tonči Tadić, Zdravko Siketić, Natko Skukan, Veljko Grilj, Iva Božičević Mihalić, Donny Domagoj Cosic, Kristina Tomić, Ivana Zamboni, Marin Vukšić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[MeV Ion Beams, Stopping Power, Ion Beam Modification of Materials, Ion Beam Analysis, Ion Beam Channeling, IBIC, RBS, PIXE, PIGE]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[In the recent years MeV ions have been extensively utilized as indispensable powerful tool in a wide range of materials science research. Ions are very efficient in creating numerous ionizations on their path through the material by ejecting/exciting electrons (electron stopping) and in creating vacancies by recoiling the whole atoms (nuclei) from their lattice sites (nuclear stopping). Therefore, irradiation of materials with energetic ion beams is considered as a) an efficient tool to alter materials physical, chemical, electrical and optical properties and b) a sensitive probe that can be used to characterise materials using some of the Ion Beam Analysis (IBA) methods. Understanding of complicated dynamical processes that lead to structural modifications of materials requires the knowledge of experimental data related to kinematics of defects during and after irradiation. Therefore the goal of the present proposal is experimental study of the time evolution of radiation induced changes induced by energetic (MeV) ion beams and their characterization using the RBI Tandem Accelerator Facility. The focus will be on studying: (i) influence of electronic stopping and related nanostructuring of materials by ion track methodology; (ii) influence of nuclear stopping to radiation damage and amorphization in crystals, including crystalline and functional materials of interest for future fusion reactors; (iii) charge transport properties in crystalline materials, focusing on novel semiconductor materials for radiation detection.  Experimental methodology relies mostly on the unique RBI dual-beam end station that will be used for ion beam irradiations and simultaneous characterization of induced changes using IBA methods like RBS and PIXE in channelling mode, ERDA, NRA and PIGE, as well as IBIC (Ion Beam Induced Charge).]]></summary_en></project><project>
<id>1741</id><title_hr><![CDATA[Razvoj suvremenog pravnog i osigurateljnog režima za hrvatske marine - unapređenje konkurentnosti, sigurnosti, sigurnosne zaštite i zaštite morskog okoliša]]></title_hr><title_en><![CDATA[Developing a Modern Legal and Insurance Regime for Croatian Marinas - Enhancing Competitiveness, Safety, Security and Marine Environmental Standards ]]></title_en><user_id>4076</user_id><user_firstLast_name>Adriana Vincenca Padovan</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2013-11</proposal_call><code>UIP-2013-11-3061</code><acronim><![CDATA[DELICROMAR]]></acronim><duration>01.03.2016 - 28.02.2019</duration><status>Završio</status><financ_value>52.442,52 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Pravo, </scie_field_hr><scie_field_en>Law, </scie_field_en><institution_hr><![CDATA[Hrvatska akademija znanosti i umjetnosti]]></institution_hr><institution_en><![CDATA[Croatian Academy of Sciences and Arts]]></institution_en><team_members_id>4077, 2814, 4464, 4201, 4194, 3984, 18987, 4386, 4187, </team_members_id><team_members_names><![CDATA[Vesna Skorupan Wolff, Nikoleta Radionov, Dorotea  Ćorić, Ranka Petrinović, Nikola Mandić, Božena Bulum, Iva Tuhtan Grgić, Marija Pijaca, Lana Ofak, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[marina, nautical tourism, transport law , marine insurance, liability, safety, security, marine environment]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The proposed research project shall consist of an examination of the existing legal regime governing the establishment, management and the activities of the nautical tourism ports in Croatia, with a special focus on marina operator’s liabilities, insurance arrangements, standards of maritime safety and security and marine environmental protection; comparative analysis of the respective legislation, insurance arrangements and court practice in the European countries; analysis of the European marina operators’ common practices, general terms and conditions, their experiences in the combat against and dealing with the adverse events such as vessel thefts, fire, unauthorised entry, marine accidents within the port, marine pollution, etc; proposing improvements in the legal framework relating to the regime of liability and insurance of the Croatian marina operators, with a view of enhancing their competitiveness, safety, security and environmental protection standards; in particular, a recommended model of general terms and conditions would be created as an innovative business solution for marina operators and a possible reform of the respective positive legislation would be proposed, paying due respect to the necessary compliance with the relevant EU legislation. The proposed project is aimed at consolidating the relevant national legislation and clarifying the related legal concepts through the currently lacking doctrine, with a view of unifying the domestic court practice and contributing to legal certainty in the interest of all parties involved. This should lead to a progress and further sustainable development of the nautical tourism sector in Croatia subject to the requirements of the marine environmental protection, maritime safety and security, particularly considering the country’s strategic orientation to that sector of economy and the planned substantial increase of the nautical tourism ports’ berthing capacities in the following years.]]></summary_en></project><project>
<id>1742</id><title_hr><![CDATA[Sloboda volje, uzročnost i slučaj]]></title_hr><title_en><![CDATA[Free Will, Causality and Luck]]></title_en><user_id>242</user_id><user_firstLast_name>Filip Grgić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-5343</code><acronim><![CDATA[FreeWilL]]></acronim><duration>01.07.2014 - 30.06.2018</duration><status>Završio</status><financ_value>42.471,30 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filozofija, </scie_field_hr><scie_field_en>Philosophy, </scie_field_en><institution_hr><![CDATA[Institut za filozofiju]]></institution_hr><institution_en><![CDATA[Institute for Philosophy in Zagreb]]></institution_en><team_members_id>1441, 3206, 2690, 3485, 3345, 2634, 4359, 4870, 1381, 17854, </team_members_id><team_members_names><![CDATA[Pavel Gregorić, Boris Kožnjak, Tvrtko Jolić, Ljudevit Hanžek, Dario Škarica, Ivana Skuhala Karasman, Marijan Palmovic, Tomislav Janović, Davor Pećnjak, Anna Kocsis, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[free will, causality, luck, determinism, compatibilism, moral responsibility, consciousness]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The overall goal of our research is to contribute to our deeper understanding of what is involved in having and experiencing free will by offering some new insights and arguments in the pertaining areas. The more specific goal of our project is to produce original contributions in some central areas of research into free will, in the following disciplines: metaphysics, philosophy of mind, ethics, history of philosophy, philosophy of physics, as well in philosophical interpretations of relevant results of psychology and neuroscience. The most specific goals of the research are the following. First, we plan to show that deterministic threats to free will are surmountable. Second, we plan to show that indeterministic threats (i.e. those based on randomness and luck) are also surmountable. Third, we will argue that some problems with compatibilistic accounts are more serious than has hitherto been recognized. This is due, first, to the fact that, in our opinion, compatibilism is also susceptible to a specific luck objection, and second, to the fact that it is sometimes based on insufficiently clear notions of causality, determinism and natural laws. Fourth, we will argue that Aristotelian version of compatibilism can bring some fresh light to contemporary discussions, but that it is also susceptible to a specific luck objection.Research activities can be grouped under five main headings: 1. Causality, laws of nature and luck (1.1. Causality, laws of nature and action; 1.2. Indeterminism and luck; 1.3. The varieties of determinism), 2. Brain, mind and agency (2.1. Freedom and consciousness, 2.2. Mental causation and ascriptions of intentionality, 2.3. Some perspectives from neuroscience), 3. Moral responsibility (3.1. Principle of Alternative Possibilities, 3.2. Bioenhancement and responsibility), 4. Aristotelian perspective (4.1. Aristotle’s compatibilism, 4.2. Aristotle on moral responsibility and luck), 5. Free will, determinism and the quantum rescue.]]></summary_en></project><project>
<id>1743</id><title_hr><![CDATA[Nejednakosti i primjene]]></title_hr><title_en><![CDATA[Inequalities and Applications]]></title_en><user_id>3427</user_id><user_firstLast_name>Josip Pečarić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-5435</code><acronim><![CDATA[INEQUALITIES]]></acronim><duration>01.06.2014 - 30.05.2018</duration><status>Prekinut</status><financ_value>72.616,68 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Tekstilno-tehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Textile Technology]]></institution_en><team_members_id>1499, 3770, 4166, 3837, 3777, 4003, 3774, 630, 524, 3034, 3820, 4020, 3074, 3745, 3852, 3541, 3503, 3423, 857, 3762, 3736, 592, 3861, 3040, 3744, 4178, 3869, 3818, 795, 3484, 1149, 3389, 584, 3707, 2673, </team_members_id><team_members_names><![CDATA[Andrea Aglić Aljinović, Maja Andrić, Senka Banić, Ana Barbir, Josipa Barić, ILKO BRNETIĆ, Tomislav Burić, Vera Čuljak, Neven Elezović, Iva Franjić, Božidar Ivanković, Slavica Ivelić Bradanović, Julije Jakšetić, Rozarija Jakšić, Dragana Jankov Maširević, Milica Klaričić Bakula, Sanja Kovač, Mario Krnić, Kristina Krulić Himmelreich, Neda Lovričević, Anita Matković, Jadranka Mićić Hot, Zlatko Pavić, Ivan Perić, Jurica Peric, Tibor Poganj, Dora Pokaz, Marjan Praljak, Mihaela Ribičić Penava, Mirna Rodić Lipanović, Ksenija Smoljak, Sanja Varošanec, Ana Vukelić, Predrag Vuković, Lenka Vukšić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[inequalities, convexity, operators, asymptotic expansions, series of special functions]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The proposed research project belongs to the category of theoretical research in fundamental sciences, with the main purpose to stimulate gaining new knowledge. The general purpose of this project is to contribute to the systematic development of the theory of inequalities and to its integration in the current trends in mathematics, especially in the fields of real, functional and numerical analysis. Our aim is also to create and maintain a competent team of researchers whose relevant results and cooperation with other field experts from all over the world will contribute to the promotion of Croatian mathematics worldwide.Specific objectives are:-to improve, refine, interpolate, generalize Jensen’s type inequalities and related inequalities such as Jensen-Steffensen, Hermite-Hadamard, Jensen-Mercer etc.-to prove some generalizations, improvements and refinements of some classical inequalities (Holder, Minkowski, Hilbert, Hardy, Ostrowski, Gruss, Opial, Chebyshev etc.) in various settings-better understanding of different kinds of convexities (higher convexities, s-convexity and h-convexity, exponential convexity, local convexities, Schur-convexity, superquadracity etc.) with applications in inequalities;-to give further extensions and applications of the Mond-Pečarić method in operator theory, especially in obtaining reverse type operator inequalities;-to develop methods and applications of asymptotic expansions and series of special functions (asymptotic expansion and comparison of bivariate and multivariate means; research in series of Bessel and Bessel-like functions, integral expressions and summation formulae for Neumann and Kapteyn series, establishing sharp truncation error estimates occuring in sampling series approximations etc.).We expect to publish more than one hundred papers in this project period. One of our aims is to give overviews of the obtained research results. We plan to publish at least five monographs on these topics.]]></summary_en></project><project>
<id>1747</id><title_hr><![CDATA[Supramolekulska sinteza samo-organizirajućih funkcionalnih nanomaterijala i kompleksnih kemijskih sustava]]></title_hr><title_en><![CDATA[Supramolecular Synthesis of Self-Assembled Functional Nanomaterials and Complex Chemical Systems]]></title_en><user_id>348</user_id><user_firstLast_name>Leo Frkanec</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-7387</code><acronim><![CDATA[SInFONIA]]></acronim><duration>01.09.2014 - 30.09.2018</duration><status>Završio</status><financ_value>84.809,87 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>689, 4307, 963, 959, 1104, 4852, </team_members_id><team_members_names><![CDATA[JANJA MAKAREVIĆ, Milan Jokić, Tomislav Portada, Tihomir Pospišil, Ruža Frkanec, Adela Štimac, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Supramolecular Chemistry, Self-Assembly, Gels, Hydrogels, Functional Materials, Nanomaterials, Molecular Surface Recognition, Complex Chemical Systems]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The aim of this project proposal is supramolecular synthesis of self-assembled functional materials and study thus created complex chemical systems. Such systems exhibit a complex array of morphologies and dynamics and have a huge potential for new applications in areas ranging from materials science to medicine. The bottom–up synthesis of highly complex functional materials from simple modular blocks is an intriguing area of research. These hierarchically assembled systems extend beyond the individual molecule and rely on non-covalent interactions in a directed self-assembly process. Intrinsic properties of the materials can be modified by exploiting dynamic and specific uni-directional interactions among building blocks, thus allowing construction of novel supramolecular structures. These supramolecular networks belong to a novel category of soft biomaterials exhibiting attractive properties. Research in this project will include the formation of dynamic polymeric networks through molecular recognition and complex assembly formation. Self-assembly of small organic molecules is a suitable method for synthesis of organic nano-structured materials. LWM organo- and hydro-gels with oxalamide units represent construction units with high H-bonding potential; they are self-complementary, capable of unidirectional H-bonding suited for construction of self-assembled with fibrous morphology. In continuation of our previous research the attention will be focused on two main areas of research 1. nanofabrication; preparation of new materials by polymerization through cross linking the gel network or transcript to the TEOS and development of new organic materials that incorporate photoactive functional groups, and 2. bioinspired supramolecular systems for detection and degradation of fibrous supramolecular aggregates, such as Aß-protein and amyloid plaques (that are a major cause of Alzheimer’s disease) and vesicles functionalization for  surface molecular recognition studies. ]]></summary_en></project><project>
<id>1751</id><title_hr><![CDATA[Translacijsko istraživanje neuroplastičnosti disanja i učinka intermitentne hipoksije u anesteziji i spavanju]]></title_hr><title_en><![CDATA[Translational research on neuroplasticity of breathing and effect of intermittent hypoxia in anesthesia and sleep]]></title_en><user_id>4553</user_id><user_firstLast_name>Zoran Đogaš</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-5935</code><acronim><![CDATA[TIHO2_SLEEP_BREATH]]></acronim><duration>01.09.2014 - 31.08.2020</duration><status>Završio</status><financ_value>131.395,58 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Clinical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Split School of Medicine]]></institution_en><team_members_id>4542, 83, 4547, 4549, 4543, 3359, 4635, 182, 65, 6675, 6725, 6329, 7034, 6899, 7175, 19211, </team_members_id><team_members_names><![CDATA[Ivana Pavlinac Dodig, Maja Rogić, Renata Pecotić, Maja Valić, Linda Lušić, Sunčana Kukolja Taradi, Mladen Carev, Tina Tičinović Kurir, Joško Božić, Mario Mihalj, Goran  Račić, Nenad Karanović, Toni Brešković, Marin Šimunić, Dušan Šuput, Tea Galić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[intermittent hypoxia, phrenic long term facilitation, respiratory neuroplasticity, sleep apnea, neurophysiology, polysomnography]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Our understanding of the brain control of breathing and awareness of the widespread prevalence of obstructive sleep apnea syndrome (OSAS) have both increased in the last decade or two. The link between the two is poorly understood. There is growing evidence that OSAS contributes to the initiation and progression of hypertension, heart failure, cardiac ischemia, stroke and cognitive decline. Chronic sympathetic activation resulting in elevated sympathetic nerve activity and cardio-respiratory sensitivity to hypoxia appears to be important. Still, the exact mechanisms underlying the link between OSA and cardiovascular and neurophysiologic disturbances are not completely known. Intermittent hypoxia (IH) in experimental animals can mimic periods of repeated apneas seen in OSAS patients. Exposure to repeated bouts of hypoxia in human leads to increased sympathetic activity, whilst intermittent hypoxia in experimental animals evokes increases in phrenic and sympathetic nerve activities. The proposed study will examine the role of neurotransmitters/neuromodulators (e.g. serotonin and opioids) in evoking sympathetic long-term facilitation using anesthetized animal model of IH.The only way to understand complex pathophysiological interactions in OSAS patients is to use translational and multidisciplinary approach, as proposed in this project. Our focus in the human studies is to study neurophysiologic (brain motor control, control of breathing, neurographic features of peripheral nerves, and muscle sympathetic activity) function in OSAS patients and the links to metabolic, stress, and cognitive parameters. Preliminary data from pilot studies suggest it is possible to achieve the new findings using this novel approach. We will also study longitudinal therapeutic effects of the gold standard therapy in OSAS such as the overnight use of continuous positive airway pressure (CPAP) devices in Split Sleep Cohort of patients, which we plan to form during the work on this project.]]></summary_en></project><project>
<id>1755</id><title_hr><![CDATA[Uloga inozitolskih fosfata i inozitolskih pirofosfata u regulaciji staničnog ciklusa]]></title_hr><title_en><![CDATA[The role of inositol phosphates and inositol pyrophosphates in the regulation of cell cycle]]></title_en><user_id>4650</user_id><user_firstLast_name>Hrvoje Banfic</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-4597</code><acronim><![CDATA[Inopyrocycle]]></acronim><duration>01.07.2014 - 30.06.2018</duration><status>Prekinut</status><financ_value>130.731,97 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>4936, 4921, 6302, 4677, 4676, 4837, </team_members_id><team_members_names><![CDATA[Vesna Lukinović-Škudar, Vladiana Crljen, John York, Dora Višnjić, Hrvoje Lalić, Vilma Dembitz, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[inositol phosphates, inositol pyrophosphates, cell cycle, matabolism, protein pyrophosphorylation]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Inositol phosphates and pyrophosphates are second messengers generated by the sequential phosphorylation of inositol 1,4,5,-trisphosphate (InsP3). Several recent studies pointed to their role in the regulation of different cellular processes in eukaryotes, yet in many instances direct mechanistic roles remain elusive. Our recent study provided genetic, metabolic and biochemical evidence that synthesis of inositol pyrophosphates through activation of Plc1 and Kcs1 play an important role in the signalling response required for cell cycle progression after mating pheromone arrest in Saccharomyces cerevisiae (Banfic et al. J. Biol. Chem. 288: 1717-1725, 2013). However, it is still uncertain which of the pyrophosphates increased is/are responsible for Kcs1-mediated effects, and it is unclear what might be the possible link between the Kcs1-mediated increase in the level of pyrophosphates and the progression of yeast cells through the S phase of the cell cycle. This is a proposal that aims to define the mechanism of pyrophosphates-mediated regulation of cell cycle progression. We will use a set of yeasts deletion mutants to define a) the particular pyrophosphate responsible for S phase-associated effects, b) to test for the possibility that inositol pyrophosphates generated during S phase progression regulate telomere length, c) to test the possibility that the increase in the level of pyrophosphates in alpha-factor synchronized cells is associated with an increase in pyrophosphorylation of the proteins and/or protein expression or modification, and d) to determine the changes in metabolism in alpha-factor synchronized cells and to correlate them with the changes in the level of inositol pyrophosphates. Overall, this proposal seeks to elucidate lipid-derived inositol phosphate signal transduction pathways in the regulation of cell cycle and metabolism. ]]></summary_en></project><project>
<id>1762</id><title_hr><![CDATA[Prirodni zeoliti kao reaktivne barijere za obradu procjednih otpadnih voda odlagališta otpada]]></title_hr><title_en><![CDATA[Natural zeolites as a reactive barrier for landfill leachate treatment]]></title_en><user_id>639</user_id><user_firstLast_name>Marina Trgo</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-4981</code><acronim><![CDATA[NAZELLT]]></acronim><duration>20.07.2014 - 19.07.2018</duration><status>Završio</status><financ_value>89.269,36 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Kemijsko inženjerstvo, </scie_field_hr><scie_field_en>Chemical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Kemijsko-tehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Chemistry and Technology]]></institution_en><team_members_id>4361, 3947, 917, 3380, 4454, 4501, </team_members_id><team_members_names><![CDATA[Nediljka Vukojević Medvidović, Jelena Perić, Ivona Nuić, Marin Ugrina, G. Diego Gatta, Sanja Slavica Matešić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[natural zeolites, landfill leachate, column method, heavy metals, reactive barrier]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Limited reserves of fresh water are a serious global problem. For that reason the main objective is to preserve the quality of all available sources of drinking water. Among all the threats to water in nature, leachate landfills are most dangerous because of their complex chemical composition and continuous uncontrolled pollution of groundwater. Processes and methods of preventing the spread of pollution into groundwater and leachate treatment are a challenge for many researchers. This proposal should be a contribution to the landfill leachate treatment using natural zeolite as a reactive barrier. This material is available in nature, environmentally compatible, thermally and chemically stable, and possesses adsorption and ion exchange properties. Depending of the surface charge, zeolites can uptake organic and inorganic positive and negative species. The desired surface charge can be achieved by chemical modification using different methods at a controlled pH value. Modified zeolites should have significantly higher removal capacities and selectivity towards pollutants contained in the landfill leachate. These wastewaters are highly concentrated, have the most complex possible composition, contain low biodegradable organic matter (halogenated hydrocarbons, aromatic hydrocarbons and phenols), inorganic ions (Cl-, NH4+, SO42-,NO3-, NO2-,PO43-), and heavy metals (Cd, Cr, Cu, Ni, Pb, Zn, Mn). Many of these components have shown excellent removal from modal solutions onto zeolite; therefore investigations will start with batch studies, continue in lab-scale fixed bed columns, and finally in scale-up and multi stage columns filled with different modified zeolites. The multi stage column performance should be carried out with real leachate collected from the regulated landfills in the Dalmatian region. The exhausted zeolite, saturated with organic and inorganic pollutants, can be thermally treated and disposed of in nature, or solidified into the cement matrix.]]></summary_en></project><project>
<id>1793</id><title_hr><![CDATA[Evocirani potencijali moždanog debla i testiranje autonomnog živčanog sustava kao metode procijene progresije bolesti u bolesnika s klinički izoliranim sindromom]]></title_hr><title_en><![CDATA[Brainstem Evoked Potentials Score and Composite Autonomic Scoring Scale as a Predictors of Disease Progression in Clinically Isolated Syndrome]]></title_en><user_id>1081</user_id><user_firstLast_name>Mario Habek</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2013-11</proposal_call><code>UIP-2013-11-2622</code><acronim><![CDATA[BACIS]]></acronim><duration>01.09.2014 - 31.08.2017</duration><status>Završio</status><financ_value>98.573,23 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Clinical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>5732, 4744, 4530, 3050, 5730, 4606, 5787, 4721, 4564, 4746, 5637, 5051, 17860, </team_members_id><team_members_names><![CDATA[Barbara Barun, Tereza  Gabelic, Ivan Adamec, Magdalena Krbot Skoric, Damir Petravić, Darija Mahović Lakušić, Branko Malojčić, Mila Lovrić, ivana zadro, Ivo Lušić, Silva Butković-Soldo, Marijana Lisak, Luka Crnošija, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[clinically isolated syndrome, multiple sclerosis, evoked potentials, autonomic nervous system testing, brainstem]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[About 85% of patients have onset of MS with a relapse, which is known as a clinically isolated syndrome (CIS). Several studies have shown that infratentorial lesions are related to conversion rate and long-term prognosis for patients with CIS and thus may help to identify patients at high risk for earlier occurrence of clinically relevant disability. Bearing in mind the poor correlation between clinical symptoms and MRI findings there is a need for ancillary tools in the evaluation of brainstem pathology in MS. The aim of the current study is to evaluate the role of the brainstem evoked potentials score (bilateral AEP, bilateral ocular and cervical VEMP and bilateral tongue SSEP), the modified evoked potentials score (combination of brainstem evoked potentials score and VEP and SSEP of the median and tibial nerve) and standardized autonomic nervous system testing (Composite Autonomic Severity Score (CASS)) in the prediction of conversion from CIS to MS and accumulation of future disability. After 24 months of follow-up, this study could reveal the prognostic value of the brainstem EP score, modified EP score and CASS in patients with CIS on a number of parameters including: time until second relapse, accumulation of disability, accumulation of MRI lesions in the first 6 months, time to conversion from CIS to MS according to the 2010 revision of the McDonald criteria, number of relapses in the first 2 years of follow up. It can be presumed that the brainstem EP score and CASS score as direct and indirect measures of brainstem dysfunction, respectively will prove as reliable markers of future disability of CIS and MS patients. As a consequence, this would allow us to start more appropriate treatment in a subset of patients with higher probability of worse outcome.]]></summary_en></project><project>
<id>1806</id><title_hr><![CDATA[Rimska ekonomija u Dalmaciji: proizvodnja, distribucija i potražnja u svijetlu keramičarskih radionica]]></title_hr><title_en><![CDATA[Roman Economy in Dalmatia: production, distribution and demand in the light of pottery workshops]]></title_en><user_id>3064</user_id><user_firstLast_name>Goranka Lipovac Vrkljan</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-3973</code><acronim><![CDATA[RED]]></acronim><duration>01.07.2014 - 30.06.2018</duration><status>Završio</status><financ_value>53.089,12 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Arheologija, </scie_field_hr><scie_field_en>Archeology, </scie_field_en><institution_hr><![CDATA[Institut za arheologiju]]></institution_hr><institution_en><![CDATA[Institute of Archaeology in Zagreb]]></institution_en><team_members_id>2786, 3216, 7577, 21192, 5318, 21199, 22964, </team_members_id><team_members_names><![CDATA[Ivana Ožanić Roguljić, Ana Konestra, Bartul Šiljeg, Marina Ugarković, Mato  Ilkić, Nera Šegvić, Fabian  Welc, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Roman economy, Dalmatia, pottery, landscape archaeology, archaeometry]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Main goal of the RED project is to found out as much as possible about production, distribution and demand of goods in Roman Dalmatia through most common material found in arhaeological excavations – ceramics. From Late Hellenistic period when Central Dalmatia was enrolled in vivid Mediterranean trade, not only as a receiver of everything that comes from the larger centre, but also as a driving force of social and economic changes establishing pottery manufactures. This social transformation was enhanced by Romans. Trade of ceramic objects  is one of the main starting points for understanding the history of the Roman economy and society. For such scientific research it is necessary to establish a project using archaeometric analysis and archaeological research and a database of ceramics. Landscape archaeology methods such as field surveys, GIS, sampling patterns and statistical analysis will be used to analyse and interpret the wealth of data. RED project will include the development of an online database of documentary, archaeological material and archaeometric samples. Aim of this project will also be to establish relations between local production to the imports and to what extent was production in province Dalmatia driven by consumer demand and involvement of provincial communities within the Late Hellenistic/Republican and Imperial Roman economy.]]></summary_en></project><project>
<id>1807</id><title_hr><![CDATA[Primjena inovativnih tehnologija u proizvodnji biljnih ekstrakata kao sastojaka funkcionalne hrane]]></title_hr><title_en><![CDATA[Application of innovative technologies for production of plant extracts as ingredients for functional food]]></title_en><user_id>1243</user_id><user_firstLast_name>Verica Dragović-Uzelac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-3035</code><acronim><![CDATA[IT-PE-FF]]></acronim><duration>01.09.2014 - 31.08.2018</duration><status>Završio</status><financ_value>128.475,68 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Prehrambena tehnologija, </scie_field_hr><scie_field_en>Food technology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Food Technology and Biotechnology]]></institution_en><team_members_id>2657, 2702, 2644, 223, 2509, 2593, 2615, 2512, 2830, 1062, 1002, 1330, 1056, 2663, 2558, 3057, 3314, 5708, 17829, 24300, 25335, </team_members_id><team_members_names><![CDATA[Damir Jezek, Mladen Brnčić, Branka Levaj, IRENA LANDEKA JURČEVIĆ, Senka Djaković, Marijana Jukić, Danijela Bursać Kovačević, Jasmina Lapić, Ivana Kmetič, Sandra Pedisić, Ivona Elez Garofulić, Maja Repajić, Zoran Zorić, Sven Karlović, Marina Tranfić Bakić, Teuta Murati, Domagoj Đikić, Ivanka Žutić, Vanja Plazibat, Predrag Putnik, Domagoj Gabrić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[medicinal and aromatic plants, innovative technologies, plant extracts, bioactive compounds, bioavailability, antioxidant properties ]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Medicinal and aromatic plants (MAPs) contain numerous bioactive compounds (BACs) (e.g. polyphenols, carotenoids, organosulphur compounds) that can affect the nutritive, chemical, microbiological, and sensory quality of food products. Additionally, they may provide numerous positive effects to the human health (such as risk reduction for: cardiovascular disease, diabetes, obesity, hypertension etc.). Due to large structural diversity among different groups of BACs and their physical/chemical properties it is important to identify/optimize the most effective extraction methods required to isolate and/or separate them from other plant components. Hence, various innovative extraction techniques (e.g. microwave-, ultrasound- and high-pressure- assisted extraction) will be tested for plant extracts production with high BACs content from selected MAPs grown in Croatia. Each applied extraction technique will be optimized with regards to particular MAP, increasing extraction yield, enhancing quality of extract, shortening extraction time, and decreasing solvent consumption. MAPs extracts and/or BACs will be analyzed for antioxidant properties with application of various assays (e.g. total antioxidant, hydrogen peroxide scavenging, and free radical scavenging, metal chelating activities). Antiproliferative effects against tumor cells and possible protective role from lipid oxidation (including antioxidant activity) will be tested in appropriate cell line model system. The MAP extracts (dried/liquid) and BACs (extracted and/or purified separately or in mixtures) will be studied in animal models for bioavailability; absorption; antioxidant activity; as ingredient for functional food products (fortified beverages and snack bars based on Mediterranean fruits), and for possible use in diabetic/hypercholesteremic management. The obtained results may provide novel opportunities for functional product categories that are likely to have positive benefits on human health.]]></summary_en></project><project>
<id>1808</id><title_hr><![CDATA[Promjenjivost Sunca i zvijezda]]></title_hr><title_en><![CDATA[Solar and Stellar Variability]]></title_en><user_id>4850</user_id><user_firstLast_name>Bojan Vršnak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-6212</code><acronim><![CDATA[SOLSTEL]]></acronim><duration>01.09.2014 - 31.08.2018</duration><status>Završio</status><financ_value>131.715,83 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Geodetski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Geodesy]]></institution_en><team_members_id>6306, 6078, 6028, 4326, 5550, 5899, 6152, 6121, 6181, 19711, </team_members_id><team_members_names><![CDATA[Hrvoje Božić , Roman Brajša, Davor Sudar, Domagoj Ruždjak, Tomislav Žic, Jaša Čalogović, Mateja Dumbović, Rajka Jurdana-Šepić, Ivana Poljančić Beljan, Ivica Skokić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[solar activity, space weather, climate, heliosphere, sun-like stars, variable stars, binary stars, accretion discs, exoplanets, substellar companions]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The proposed four-year project connects solar physics, solar-terrestrial physics, heliospheric physics, space weather & climate, geophysics, and stellar physics. It is based on empirical/interpretative, theoretical/analytical, and theoretical/numerical approach, and concerns all astrophysical problems currently in focus of the research at the Hvar Observatory (HO) of the Faculty of Geodesy of the University of Zagreb. Thus, the proposed program is in a great deal determined by, and directed towards, effective exploitation of the observational capacities and manpower of HO. The project is divided into five thematic topics: 1) solar activity and eruptive phenomena in the solar atmosphere; 2) solar-activity impact on the Earth; 3) stellar eruptive activity; 4) radiation processes in solar and stellar atmospheres; 5) exoplanets and substellar companions. In the first topic special attention is devoted to the research of the physics of coronal mass ejections and solar flares, since they drive the most intense geomagnetic storms, as well as changes of radiation belts and ionosphere. The central issue of the second topic is the influence of the solar variability on the Earth climate. The third topic is devoted to stellar eruptive magnetic-field activity, aiming to provide a better understanding of the long-term evolutionary aspect of the solar activity. The fourth topic is an important subject not only for astrophysics, but also for plasma physics in general, since it provides an alternative view on plasma instabilities and emission processes. The fifth topic is a timely astrophysical theme, since it provides new insights into physics of planetary systems, and is very important subject for understanding of the solar-system formation and evolution.]]></summary_en></project><project>
<id>1837</id><title_hr><![CDATA[Urbanizam naslijeđa - Urbanistički i prostorni modeli za oživljavanje i unaprjeđenje kulturnoga naslijeđa]]></title_hr><title_en><![CDATA[Heritage Urbanism - Urban and Spatial Planning Models for Revival and Enhancement of Cultural Heritage]]></title_en><user_id>1458</user_id><user_firstLast_name>Mladen Obad Šćitaroci</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-2032</code><acronim><![CDATA[HERU]]></acronim><duration>01.09.2014 - 31.08.2018</duration><status>Završio</status><financ_value>110.757,18 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Arhitektura i urbanizam, </scie_field_hr><scie_field_en>Architecture and Urban Environment, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Arhitektonski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Architecture]]></institution_en><team_members_id>1459, 3550, 3010, 3625, 3024, 4796, 2560, 3157, 3056, 3015, 3190, 4392, 3174, 1319, 1194, 3469, 1196, 3084, 3098, 3917, 2936, 3480, 3407, 4778, 3208, 3027, 3220, 3213, </team_members_id><team_members_names><![CDATA[Bojana Bojanic Obad Šćitaroci, Alenka Delić, Sanja Gašparović, Jesenko Horvat, Vedran Ivanković, Tihomir Jukić, Damir Krajnik, Nenad Lipovac, Ivan Mlinar, Lea Petrović Krajnik, Biserka Dumbović Bilušić, Jasenka Kranjčević, Tamara Marić, Ana Mrđa, Tin Oberman, Boško Opalić, Marko Rukavina, Igor Gojnik, Irma Huić, Marina Pavković, Ksenija  Petrić, Dario Sironić, MARIJANA SIRONIĆ, Nikša Božić, Boris Dundović, Mirna Meštrović, Ksenija Radić, Ana Sopina, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Cultural Heritage, Urban Planning, Spatial Planning, Heritage Enhancement, Heritage Revival]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Croatia’s urban heritage is at least 25 centuries old. Examples of cultural/architectural and landscape heritage in Croatia are numerous, valuable and diverse. Part of this heritage is recognised worldwide and is protected by UNESCO. Croatia’s most valuable heritage is protected at a national level, although a part of it has, as yet, not been recognised. For various reasons the numerous examples of Croatian heritage are in a poor condition and decaying because they don’t have a permanent use and are not included in the life of cities and towns, despite being formally protected.In former research project, Urban and Landscape Heritage of Croatia as Part of European Culture, cultural heritage was researched in an attempt to present its values and traits as part of Croatia’s national identity and culture. The new project proposal partly supplements previous project thematically and uses results of this research, but the focus of research is on the creative, sustainable and responsible usage of urban, architectural and landscape heritage, which is a non-renewable resource. Contemporary attitudes of conservationists on the holistic protection based on international conservation documents connect protection with urban and regional planning through the concept of sustainable development. The aim of proposed research is to affirm heritage as an active space and spatial resource, to include it in future life and to allow it to be the initiator and active participant in sustainable spatial, social and cultural, economic and touristic development.The research will be based on the selected case studies for each type of cultural heritage. The aim is to define spatial criteria, methods and models for revitalisation and for the implementation of new projects within cultural heritage which may contribute to their enhancement. The project results (criteria, methods, models) will be applied in spatial and urban planning and conservation practices, and will be of far-reaching impact.]]></summary_en></project><project>
<id>1839</id><title_hr><![CDATA[Procjena prihvatnog kapaciteta za turiste u zaštićenim područjima prirode]]></title_hr><title_en><![CDATA[Assessment of Carrying Capacity for Tourists in Nature Protected Areas]]></title_en><user_id>2551</user_id><user_firstLast_name>Jadranka Pečar Ilić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-2202</code><acronim><![CDATA[ACCTA]]></acronim><duration>01.07.2014 - 30.06.2017</duration><status>Završio</status><financ_value>92.729,14 eur</financ_value><scie_area_hr>Prirodne znanosti, Tehničke znanosti, Društvene znanosti, </scie_area_hr><scie_area_en>Natural sciences, Technological sciences, Social sciences, </scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>2551, 5520, 5519, 5710, 4006, 3321, 5922, 17593, 13114, 4898, </team_members_id><team_members_names><![CDATA[Jadranka Pečar-Ilić, Tin Klanjšček, Sunčana Geček, Zdenko Tkalčec, Hrvoje Carić, Jasminka Klanjšček, Drago Marguš, Nina Marn, Ivana Kušan, Tarzan Legović, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[carrying capacity, nature protected area management methods, conservation, environmental modeling, calculation, GIS,  tourism, NP Krka, PP Telašćica]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Natural protected areas (NPAs) are a crucial part of nature conservation; many of them are tourist hotspots. Managers of NPAs have to balance environmental protection and tourism to maximize socio-economic benefits while avoiding irreparable environmental consequences. Since 1978, carrying capacity for tourists (CCT) has been recognized and legislated as a crucial tool in finding the balance. CCT is traditionally defined as the maximum number of people concurrently visiting an area without irreversibly damaging physical, economic, and/or socio-cultural environment. In practice, managers determine acceptable level of environmental damage, and then use adaptive management to achieve and maintain that damage level. We propose a more conservation-oriented approach of estimating CCT that maximizes nature protection. Although every tourist damages the environment, he/she also contributes to protection by providing financial assets. Without revenues from tourism, protection is significantly underfunded because meeting protection and educational goals of NPAs requires costly activities such as research, oversight, mitigation, and management. We propose to estimate CCT as the maximum number of visitors for which the marginal contribution to nature protection is positive, with the requirement that visitor satisfaction not be compromised. We will first formalize the estimation procedure, then identify tourist activities with their consequences on the environment and socio-economic parameters, develop general models for common factors affecting environmental quality of the NPAs, and integrate the models into a GIS-based framework. Finally, we will demonstrate the approach by estimating CCT for two very different protected areas crucial for Croatian tourism and the local economy: NP Krka and PP Telašćica. While the new way of estimating CCT will initiate a paradigm shift in NPA management, the two applications will contribute to Croatia&#39;s nature conservation and economy.]]></summary_en></project><project>
<id>1844</id><title_hr><![CDATA[Enzimi purinskog reciklirajućeg ciklusa iz Helicobacter pylori i Escherichie coli ]]></title_hr><title_en><![CDATA[Purine salvage pathway enzymes from Helicobacter pylori and Escherichia coli ]]></title_en><user_id>302</user_id><user_firstLast_name>Marija  Luić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-7423</code><acronim><![CDATA[PSPE]]></acronim><duration>01.09.2014 - 30.11.2018</duration><status>Završio</status><financ_value>121.883,02 eur</financ_value><scie_area_hr>Prirodne znanosti, Biomedicina i zdravstvo, </scie_area_hr><scie_area_en>Natural sciences, Biomedicine and health sciences, </scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>690, 424, 3310, 3300, 3781, 3687, 2999, 23182, 4270, 23168, </team_members_id><team_members_names><![CDATA[Ivana Leščić Ašler, Zoran Štefanić, Saša Kazazić, Biserka Kojić-Prodić, Biserka Žinić, Vanda Plečko,  Agnieszka  Bzowska, Ante Bubić, Branimir Bertoša, Petar Knezevic, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Purine metabolism, enzyme inhibiton, drug design, H. pylori, E. coli, crystal structure, analytical biochemistry, H/D exchange, susceptibility testing]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The main goal of the proposed project is to identify new drug targets and accordingly design, prepare and characterise new drugs for Helicobacter pylori eradication. Helicobacter pylori is a bacterium that colonizes one half of the world population and it is regarded as one of the most invasive human pathogens responsible for development of many diseases. There are two possible pathways that organisms can use to synthesize purines as indispensable building blocks for DNA and RNA synthesis. However, bacterium H. pylori  uses the salvage pathway, only. Therefore, we plan to disable H. pylori growth and replication by inhibiting the key enzymes, purine nucleoside phosphorylase and adenylosuccinate synthetase, on this pathway.The proposed project includes the interdisciplinary team with expertise in the research areas of molecular biology and genetics, biochemistry and biophysics, macromolecular crystallography, biological mass spectrometry, molecular modelling, organic synthesis, analytical ultracentrifugation methods, susceptibility testing, and managing ‘big data’ through data integration (extracted from various databases). All equipment necessary to accomplish the proposed research is available in the host institution (Rudjer Bošković Institute) except for analytical ultracentrifuge available by foreign co-worker A. Bzowska (Warsaw, Poland).]]></summary_en></project><project>
<id>1845</id><title_hr><![CDATA[INTEGRATIVNI PRISTUP PROUČAVANJU TRANFORMACIJSKE ULOGE TURIZMA U 21. STOLJEĆU]]></title_hr><title_en><![CDATA[AN INTEGRATED APPROACH FOR THE STUDY OF TRANSFORMATIVE ROLE OF TOURISM IN 21ST CENTURY]]></title_en><user_id>5000</user_id><user_firstLast_name>RENATA TOMLJENOVIĆ</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-6164</code><acronim><![CDATA[TRANS-TOURISM ]]></acronim><duration>01.09.2014 - 31.03.2019</duration><status>Završio</status><financ_value>77.259,63 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, </scie_field_hr><scie_field_en>Economy, </scie_field_en><institution_hr><![CDATA[Institut za turizam]]></institution_hr><institution_en><![CDATA[Institute for Tourism in Zagreb]]></institution_en><team_members_id>5782, 7029, 1004, 3669, 5707, 5245, 5228, 5218, 7502, </team_members_id><team_members_names><![CDATA[Sanda Čorak, Daniela Angelina Jelinčić, Snježana  Boranić Živoder, ZRINKA MARUŠIĆ, Neda Telišman-Košuta, NEVEN IVANDIĆ, Nikola Ćelić, Ivan Sever, IRENA ATELJEVIC, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[culture, tourism, transformation, values, behaviour, change]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The overall objective of TRANS-TOURISM is to critically investigate the role of tourism in attaining the vision for sustainable world of peace and harmony, and to develop tools and options in order to provide practical models to harness the transformative power of tourism. The main proposition is that tourism, as an enormous economic and social force, can be a significant contributor to the vision for sustainable world. The vision for personal is an urgency today and already the new group of culture creatives is identified spearheading this movement. This vision is also embedded in the overall vision of Europe 2020 for creation of more just and inclusive societies and provision of greater quality of lives for all citizens. This proposition will be analysed from three aspects: by capturing the transformative power of past and present travel experience of the culture creatives, motivations and practises of pioneering change-makers who create transformational travel products and tourism stakeholders’ receptiveness to integrate transformational view of tourism into design of their products. The research will employ mixed-method approach, involving quantitative (surveys) and qualitative (in-depth interviews, focus groups, workshops, diary) methods. The research on the theme is in infancy and the project builds the existing research in three ways. In contrast to the existing studies, the research will focus on those whose values are transformed and will seek to capture the role of travel experience in that process, on the long term behavioural change following the travel in contrast to the existing focus on immediate post-trip attitude change. The research will also overcome the existing host – industry – guest divide, as it will include entrepreneurial perspective of transformative travel providers, mainstream industry players and host communities in the process of fostering activities which can facilitate societal transformation through tourism.  ]]></summary_en></project><project>
<id>1846</id><title_hr><![CDATA[Neuralna osnova viših spoznajnih funkcija]]></title_hr><title_en><![CDATA[Microcircuitry of higher cognitive functions]]></title_en><user_id>2567</user_id><user_firstLast_name>Zdravko Petanjek</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-5943</code><acronim><![CDATA[COGNITIVECIRCUIT]]></acronim><duration>01.07.2014 - 30.11.2018</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>3907, 4699, 5085, 3483, 4770, 2549, 2646, 2632, 5063, 4972, 18991, 12673, </team_members_id><team_members_names><![CDATA[Dubravko Jalšovec, Davor Mayer, Mislav Stjepan Žebec, Sanja Darmopil, Marija Baković, Ana Hladnik, Domagoj Džaja, Ivana Bičanić, Ivana Miler, Fadi Almahariq, Branka Hrvoj Mihic, Dora Mandić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[pyramidal neurons, interneurons, glutamate, GABA, synaptic transmission, cortical connectivity, evolution, cognition, schizophrenia, autism, layer III]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Most of our knowledge about organization of cortical circuitry comes from studies in rodents, but those results have not lead to major breakthrough for the treatment of human brain disorders. Despite common principles in connectivity, human cerebral cortex contains specific neuron types like associative layer III pyramidal neurons and subtypes of calretinin expressing GABA-interneurons. They are key elements of human microcircuitry which molecular specificity and neuronal interaction between and inside columns needs to be determined in order to assess how human cerebral cortex processes information. The aim of this project is to study organization and molecular properties of microcircuitry in the human frontal cortex that is believed to have unique features being the biological substrate for the most complex cognitive functions. The emphasis is to use histo-molecular techniques to dissect connectivity at cellular level and to establish a experimental monkey model to study microcircuitry in collaboration with Brain Dynamic Institute Marseille (http://ins.medecine.univmed.fr/) and Max Planck Institute for Evolutionary Anthropology Leipzig (http://www.eva.mpg.de/). This will enable formation of unique database providing structural, physiological, molecular and genetic fingerprint of identified neurons as well as their connectivity within the entire cortical network in primates. Such database will be extremely valuable to create a simulation model of the human brain and to understand neuronal network alterations in various brain disorders. Studying cortical circuitry in the human is in the focus of current neuroscience research. Proposed project has potential to overcome gap in knowledge at cellular level, providing information gainful for more comprehensive interpretation of data obtained by imaging studies. Through the project Croatian researchers will be trained in experimental techniques that will be implemented into Croatian research and medical institutions.]]></summary_en></project><project>
<id>1848</id><title_hr><![CDATA[Kulturna povijest kapitalizma: Britanija, Amerika, Hrvatska]]></title_hr><title_en><![CDATA[A Cultural History of Capitalism: Britain, America, Croatia]]></title_en><user_id>4485</user_id><user_firstLast_name>Tatjana  Jukić Gregurić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-1543</code><acronim><![CDATA[CHCBAC]]></acronim><duration>01.07.2014 - 30.06.2018</duration><status>Završio</status><financ_value>78.901,06 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filologija, </scie_field_hr><scie_field_en>Philology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>3808, 4823, 5020, 4315, 4929, 5089, 5189, 5401, 5527, 5906, 6602, 23126, </team_members_id><team_members_names><![CDATA[Jelena  Šesnić, Borislav Knežević, Martina Domines Veliki, Sven Cvek, Stipe  Grgas Mufa, Tihana Klepač, Vladimir Brljak, Iva Polak, Vanja Polić Jurković, Grant Farred, Kimberly Engber, Hrvoje Tutek, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[cultural history, economy, capitalism, Britain, America, Croatia]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Our claim is that a detailed analysis of what constitutes a cultural history of capitalism is indispensable for a grasp of recent Croatian cultural and political history, and of the current positioning of Croatia in Europe and the world. We start from the observation that the scholarly discourses in Croatia have so far not sufficiently acknowledged the cultural complexity of the economic sphere, especially the seminal significance of histories of Britain and America in that regard. Our methodological point of departure is therefore the assertion that the economic sphere can be understood only in reference to the entirety of culture. We intend to explore the complexity of this totality as refracted through cultural histories of Britain and America, as a horizon necessary for understanding Croatian cultural history. Our intent is to investigate complex interrelations of the sophisticated Victorian variant of capitalism and its American mutations, in the 19th and the 20th centuries. This applies primarily to Cold-War America, when capitalism contrasted to socialism becomes a totalizing formula to regulate various economic and political structures, but also the sphere of culture where public vs private is defined. Thus caught in relation to socialism, capitalism is definitive to life in the former Yugoslavia as well; this then sediments into a difficult genealogy which burdens capitalism when, after the fall of the Berlin Wall, it enters formerly socialist countries, now as a platform for understanding and regulating postsocialism. Our approach is anchored in the assumption that research based only in economy or political theory fails to shed light on the logic of capitalism. This defines our methodology: we maintain that a truly functional analysis of the impact of capitalism demands a confluence of literary history, film studies, psychoanalysis, philosophy, cultural theory and, especially, the knowledge specific to English and American Studies. ]]></summary_en></project><project>
<id>1850</id><title_hr><![CDATA[Transporna, magnetska i termodinamička svojstva odabranih anorganskih i organskih materijala]]></title_hr><title_en><![CDATA[Transport, magnetic and thermodynamic properties of selected inorganic and organic materials]]></title_en><user_id>5009</user_id><user_firstLast_name>Ivan Kokanović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-6216</code><acronim><![CDATA[TRANMAGTHERPROMAT]]></acronim><duration>01.09.2014 - 31.08.2018</duration><status>Završio</status><financ_value>98.841,88 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>1173, 5781, 5722, 3227, 6713, 17743, </team_members_id><team_members_names><![CDATA[Mario Novak, Boran Leontić, Sanda Pleslić, Mirko Baćani, Cooper John Robert, Filip Orbanić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Superconductivity, topological insulators,  metallic glasses,  nanocrystalline alloys, conducting polymers, ]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[This Project is centred on the physics of selected YBCO single crystals, HTSC, topological insulators, TI, metallic glasses, MG, nanocrystalline alloys, NCA, and conducting polymers, CP, and investigation of their transport, thermodynamic, thermoelectric, magnetic, superconducting and structural properties. The primary issue addressed in the field of HTSC is the existence of electron pockets in low magnetic fields   caused by charge density waves, CDW, in pure YBa2Cu3O6+x single crystals. We propose to measure the magnetisation and specific heat in the whole doping range  to extract the total density of states at the Fermi level and thereby determine the number of pockets.  At the same time we will look for thermodynamic signatures of the CDW phase transitions.  Other unresolved controversies which will be investigated include the doping evolution of the mean-field upper critical field and whether Gaussian superconducting fluctuations can account for the magnetisation and specific heat of both underdoped and overdoped YBa2Cu3O6+x single crystals at T>Tc. In the field of TI, we will investigate the thermoelectric properties of bismuth based chalcogenide (BiSbTeSe2) and 3D Dirac semimetals and to find the evidence of the linear dispersion and nontrivial topology of these materials. Our next aim is to achieve ferromagnetism in selected TIs; TlBi(S0.5Se0.5)2, PbSnTe and PbSnSe by doping with Mn or Fe and gain understanding of the mechanism responsible for the ferromagnetic ordering.   In the field of MG and NCA   the goal is to gain some insight into the glassy structure and mechanism involved in its crystallisation. In the field of organic conductors we intend to investigate PANI-DBSA (DBSA-dodecylbenzenesulfonic acid) thin film samples. A particular emphasis of the research will be the further development of novel apparatus to measure the magnetisation and specific heat of small single crystals which are often of the highest quality.  ]]></summary_en></project><project>
<id>1853</id><title_hr><![CDATA[Transport i kemodinamika elemenata u tragovima u slatkovodnim i priobalnim sedimentacijskim sustavima]]></title_hr><title_en><![CDATA[Transport and Chemodynamics of Trace Elements in Freshwater and Coastal Sedimentary Systems]]></title_en><user_id>60</user_id><user_firstLast_name>Goran Kniewald</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-7555</code><acronim><![CDATA[TRACESS]]></acronim><duration>01.09.2014 - 31.08.2017</duration><status>Završio</status><financ_value>93.793,66 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Geologija, </scie_field_hr><scie_field_en>Geology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>989, 624, 4900, 2726, 3584, 544, 399, 614, 5147, 5151, </team_members_id><team_members_names><![CDATA[Nevenka Mikac, Neda Vdović, Goran Mihelčić, Željka Fiket, Martina Furdek, Julijan Dobrinić, Tadej Dolenec, Irena Jurina Tokić, Niko Bačić, Mavro Lučić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[trace elements, chemodynamics, sediments, freshwater systems, coastal systems]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The aim of the proposed project entitled &#39;&#39;Transport and Chemodynamics of Trace Elements in Freshwater and Coastal Sedimentary Systems&#39;&#39;  (TRACESS) is to increase our understanding of the biogeochemical cycles that are important forfreshwater and coastal sedimentary systems in karstic areas, using specific groups of elements i.e. anthropogenic and bioactive (Cd, Co, Cr, Cu, Mn, Ni, V, Zn), rare earth elements (REE), toxic elements and compounds (organotin compounds) which were chosen to represent different biogeochemical environments where a suite of geochemical processes can be traced. ]]></summary_en></project><project>
<id>1855</id><title_hr><![CDATA[Organska zagađivala u okolišu - markeri i biomarkeri toksičnosti]]></title_hr><title_en><![CDATA[Organic Pollutants in Environment - Markers and Biomarkers of Toxicity]]></title_en><user_id>5026</user_id><user_firstLast_name>Davor Želježić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-8366</code><acronim><![CDATA[OPENTOX]]></acronim><duration>01.09.2014 - 31.08.2018</duration><status>Završio</status><financ_value>132.044,86 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Javno zdravstvo i zdravstvena zaštita, </scie_field_hr><scie_field_en>Public health and health services, </scie_field_en><institution_hr><![CDATA[Institut za medicinska istraživanja i medicinu rada]]></institution_hr><institution_en><![CDATA[Institute for Medical Research and Occupational Health]]></institution_en><team_members_id>4035, 4034, 2516, 3033, 221, 555, 549, 1390, 3076, 5303, 331, 2513, 1490, 323, 1224, 1212, 1384, 1376, 198, 4161, 4156, 2633, 341, 1223, 12850, 2649, </team_members_id><team_members_names><![CDATA[Vilena Kašuba, Ružica Rozgaj, Nevenka Kopjar, Suzana Žunec, Vedran Micek, Ivančica Trošić, Ivan  Pavičić, Ana Marija Marjanović, Ana Lucić Vrdoljak, Radovan Fuchs, Vlasta Drevenkar, Sanja Fingler Nuskern, Marija Dvoršćak, Želimira Vasilić, Gordana Mendaš Starčević, Sanja Stipičević, Snježana Herceg Romanić, Darija Klinčić, Zorana Kljaković-Gašpić, Irena Brčić Karačonji, Nataša Brajenović, Tanja Živković, Alica Pizent, Mirta Milic, Anja Mikolić, Blanka Tariba Lovaković, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[pesticides, organochlorine pollutants, genotoxicity, endocrine disruption, oxidative stress, cytoskeleton, environmental distribution, risk assessment]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The proposed project is based on Directive 2009/128/EC, the EU Thematic Strategy for Pesticides, and the Collegium Ramazzini Statement concerning control over pesticides and their impact on human health and the environment. The project will focus on studying two major pesticide classes with three subgroups per each: (A) insecticides (organophosphates, neonicotinoids, and pyrethroids), (B) herbicides (triazines, organophosphates, allelopathic), and persistent organochlorine pollutants under the Stockholm convention. Low concentrations corresponding to real-life exposures will be evaluated based on residential exposure levels, occupational exposure limits, acceptable daily intakes, and reference doses in appropriate cell lines and animal models. The malsegregation of chromosomes (X, Y, 9), integrity of gatekeeping genes (TP53, c-Myc), and protein structures (cytoskeleton components) will be studied within the transplacental genotoxic evaluation of selected pesticide groups. Among these, some are suspected to be endocrine disruptors. Potential effects on sex hormone levels will be assessed in neonatal rats and transfer via mother’s milk in pubertal rats. Oxidative stress will be estimated by measuring lipid peroxidation and activity of antioxidative enzymes in vitro and in vivo. We will study the processes affecting the distribution of pesticides in water/soil systems as well as the genotoxicity of their residues in soil and water. Results for low levels of pollutant exposure will serve to significantly extend the knowledge on their genotoxicity, cytotoxicity, sex endocrine disruption, mechanisms of oxidative stress, and distribution in the environment. Also, they will be used as a base for amending and adopting the Croatian National Action Plan for sustainable use of pesticides in accordance with demands postulated in Directive 2009/128/EC and the EU Thematic Strategy for Pesticides.]]></summary_en></project><project>
<id>1857</id><title_hr><![CDATA[Dijagnostika autizma s robotskim evaluatorom]]></title_hr><title_en><![CDATA[Autism Diagnostic Observation with Robot Evaluator]]></title_en><user_id>5054</user_id><user_firstLast_name>Zdenko Kovačić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-1024</code><acronim><![CDATA[ADORE]]></acronim><duration>01.09.2014 - 31.01.2019</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>5295, 5272, 5058, 3759, 5090, 5244, </team_members_id><team_members_names><![CDATA[Jasmina Stošić, Damjan Miklic, Frano Petric, Sanja  Šimleša, Maja Cepanec, Stjepan Bogdan, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[social robotics, humanoid robots, autism, small children, diagnostics, rehabilitation]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Autism spectrum disorder (ASD) is a developmental disorder characterized by impairment in social interaction, verbal and nonverbal communication and by repetitive behaviors and interests. The diagnosis, which is usually given during the preschool period, depends on the education and experience of human evaluators, which can be susceptible to personal bias. The ongoing collaboration between the researchers from the Faculty of Electrical Engineering and Computing (FER) and Faculty of Education and Rehabilitation Sciences (ERF) initiated the use of humanoid robots in the process of ASD diagnostic procedures in preschool children. The goal of the project is the development of a robot-based diagnostic protocol and testing of its verification in clinical settings. The robots will be used as ASD co-evaluators to help a human evaluator to assess the child behavior objectively. To the best of our knowledge, such a robot-based ASD diagnostics system will be the first of its kind. Technically, this means developing specific robot skills and behaviors to be deployed within the standard clinical diagnostic procedure of ASD. The robots will have two functions: observation and quantitative measurement of child’s social responses; and performance of standardized social presses designed to provoke child response. This involves actions such as analyses of the audio signal and differentiation of vocalizations and speech, detection of eye-gaze direction, performance of different actions and gestures and utilization of human-robot and robot-robot interaction to attract child attention. Our interdisciplinary approach includes ERF&#39;s development of diagnostic protocol and its testing on children with and without ASD and FER&#39;s realization of needed robot behaviors using methods and algorithms from social signal processing, computer vision, machine learning and cognitive reasoning. This involves work on cooperation, cognition and human-robot interaction, focusing on multimodal communication.]]></summary_en></project><project>
<id>1858</id><title_hr><![CDATA[Višenamjensko očitavanje DNA / RNA sekundarne strukture molekularnim kemijskim senzorima]]></title_hr><title_en><![CDATA[Multifunctional molecular sensing of DNA/RNA secondary structure by chemical sensors]]></title_en><user_id>480</user_id><user_firstLast_name>Ivo Piantanida</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-1477</code><acronim><![CDATA[DNA/RNA-MolSense]]></acronim><duration>01.09.2014 - 31.10.2018</duration><status>Završio</status><financ_value>131.119,86 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>1214, 2953, 1232, 3781, 3684, 1476, 444, 2648, 5802, 17784, </team_members_id><team_members_names><![CDATA[Marijana Radić Stojković, Lidija-Marija Tumir, Ivo Crnolatac, Biserka Žinić, Dijana Saftić, Željka Ban, Vilko Smrečki, Aleksandar Višnjevac, Carsten Schmuck, Prof. Dr., Tamara Šmidlehner, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Molecular sensing, DNA/RNA, fluorescence, oligopeptide, nucleobase]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Molecular recognition of DNA/RNA is of fundamental importance e.g. for gene transcription and regulation, protein synthesis or cell-division. Small molecules selectively targeting specific DNAs or RNAs are therefore highly interesting not only to understand such processes in more detail but also for potential medicinal applications, as sensors or probes for fluorescence based bioimaging as well as for analytical purposes in isolated biosamples. Proposal is based on the collaboration between I. Piantanida and Prof. Dr. C. Schmuck (Germany), joined results in leading chemistry journals (Chemistry, Eur. J; 2010 and 2012, J. Am. Chem. Soc. 2012; Org. Biomol. Chem. 2011, Bioorg. Med. Chem. Lett. 2008). We want to design, synthesize and study highly selective probes for the sensing of DNA/RNA with emphasis on the multi-purpose probes: single molecules able to simultaneously differentiate by several highly sensitive spectrometric methods between the most common secondary structures of ds- DNA/RNA. For increased affinity and selectivity, we plan to test new, more efficient fluorophores (cyanine, phenanthridine, fluorescent nucleobases-Piantanida group) combined with pyrrole-guanidinium cations (Schmuck group) and explore structural diversity of the compounds, by combinatorial approach (solid phase synthesis) based on peptide backbone carrying recognition units/fluorophores. The interaction with DNA/RNA will be studied by Piantanida group (UV/Vis, fluorescence, CD/LD spectroscopy, DSC/ITC microcalorimetry), screening of oligopeptide libraries by IRORI method and atomic force microscopy by Schmuck group. Proposal addresses CSF goals: a) support the collaboration with well-established international leaders, b) foster training of young researchers by work on the INTERNATIONAL research; c) expected results with commercializing potential (novel biochemical probes and/or drugs). The latter feature (c) will be studied within FP7-REGPOT “Innomol” Project at Ruđer Bošković Institute.]]></summary_en></project><project>
<id>1862</id><title_hr><![CDATA[Između Dunava i Mediterana. Uloga rimske vojske u mobilnosti ljudi i roba na tlu Hrvatske u antici. ]]></title_hr><title_en><![CDATA[Between the Danube and the Mediterranean. Exploring the role of Roman military in the mobility of people and goods in Croatia during the Roman Era]]></title_en><user_id>4028</user_id><user_firstLast_name>Mirjana Sanader</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-6505</code><acronim><![CDATA[RoMiCRO]]></acronim><duration>15.06.2014 - 14.06.2018</duration><status>Završio</status><financ_value>78.832,04 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Arheologija, </scie_field_hr><scie_field_en>Archeology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>7522, 7512, 7519, 7513, 7516, 7534, 7526, 7532, 7537, 7545, 7547, 7536, 7551, 7548, 17731, </team_members_id><team_members_names><![CDATA[Marina Milićević Bradač, Domagoj Tončinić, Ina Miloglav, Iva Kaić, Vinka Matijević, Domagoj Perkić, Igor Vukmanić, Sanja Ivčević, Ana Pavlović, Saša Denegri, Tatjana Lolić, Zrinka Buljević, Zrinka Šimić-Kanaet, Tomislav Šeparović, Mirna Vukov, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Roman Empire, Danube, Mediterranean, mobility, economy, Roman military, local elite.]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The objective of the project is to investigate and extend scientific information to aid in solving as yet unanswered questions about the significance of the Roman military in changes that occurred on the territory of Republic of Croatia in the period from the first contacts with Rome (229 BC) to the end of the Marcomannic Wars (180 AD). The geopolitical strategy of Rome in conquered regions was to encourage the integration process, where the Roman army gave its contribution. Archaeological data testify that the indigenous communities of Illyricum reacted differently to this process. Some were willing to accept the Roman heritage (e.g. Liburnians), while the others (e.g. Delmatae) were providing resistance. Given previous research today we have a number of valuable studies about certain aspects of Roman domination. However, they are primarily focused either on the ancient written sources or the archaeological material from Dalmatia and Pannonia. This research of the integration would cover for the first time the Roman military presence on the area of Croatia. The main focus is on the Roman military sites along the Dalmataean and the the Danube limes. New data will be derived using the methodology purposely created for this project and includes archaeological survey, classification, comparison and evaluation of all available data both archaeological and ancient sources with the application of the variable of geographic origin. Such research has never been undertaken in Croatia. The results would fill the informational gaps that exist for this part of the Empire through the analysis of the largest possible amount of information about the Roman army activities and the integration of indigenous people. The project leader’s research has focused so far on the problems of Roman provincial archaeology. Many years of her successful research of and of all the collaborators guarantee the sustainability of the approach and the successful implementation of the project objectives.]]></summary_en></project><project>
<id>1865</id><title_hr><![CDATA[Hrvatska filozofija i znanost u europskom kontekstu od 12.-20. stoljeća]]></title_hr><title_en><![CDATA[Croatian philosophy and science in the European context between the 12th and 20th century]]></title_en><user_id>1321</user_id><user_firstLast_name>Pavo Barišić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-3524</code><acronim><![CDATA[HRFIZ]]></acronim><duration>01.06.2014 - 31.05.2018</duration><status>Završio</status><financ_value>53.752,74 eur</financ_value><scie_area_hr>Humanističke znanosti, Prirodne znanosti, </scie_area_hr><scie_area_en>Humanities, Natural sciences, </scie_area_en><scie_field_hr>Filozofija, </scie_field_hr><scie_field_en>Philosophy, </scie_field_en><institution_hr><![CDATA[Institut za filozofiju]]></institution_hr><institution_en><![CDATA[Institute for Philosophy in Zagreb]]></institution_en><team_members_id>1321, 1442, 748, 307, 505, 808, 811, </team_members_id><team_members_names><![CDATA[Pavo Barišić, Bruno Ćurko, Mihaela Girardi-Karšulin, Željka Metesi Deronjić, Snježana Paušek-Baždar, Nenad Trinajstić, Vanja Flegar, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Croatian philosophy, history of philosophy, history of science, natural sciences,aesthetics, Neo-Platonism, Aristotelianism, alchemy, postmodern]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[We hereby submit to the HRZZ the project “Croatian philosophy and science in the European context between the 12th and 20th century” for financial support. Due to the integrative nature of the modern world, the primary issue for each member of the European and global community is the preservation of its identity, which implies cherishing national culture and the inherent philosophical and scientific tradition. Croatia’s accession to the EU has imposed an even stronger need for preservation. Research into Croatian philosophy and science started at the turn of the 20th century, but to re-examine national identity each generation inevitably has to revert to tradition, which is why studies of the works of Croatian philosophers and scientists should be our permanent mission. Continuing the work of previous researchers, our desire is to analyse the still unexplored aspects of Croatian philosophy and science in order to gain better insight into their contribution to European philosophy and science. That is why this project plans to tackle the following topics: “Reception of Plato’s philosophy in the works of Croatian philosophers between the 12th and 16th century”; “The development and shifts in Aristotelianism during the 16th and 17th century”; “The philosophy of Juraj Dragišić”; “Croatian aesthetics and poetics in the European context between the 16th and 18th century”; “The relationship between natural philosophy and alchemy in the works of Croatian authors Andrija Dudić, Pavle Skalić, and Frane Petrić”; “The alchemy in Croatia from 14th to 18th”century; “The history of Croatian chemistry during the development of natural sciences in the 19th and 20th century”; “A review of the history of Croatian philosophy in the 19th and 20th century”. The aim of this project is an anthology that would present the results of four years of research and serve as the basis for creating a comprehensive overview of the entire history of Croatian philosophy and science.]]></summary_en></project><project>
<id>1875</id><title_hr><![CDATA[Kromatografsko pročišćavanje biomolekula i njihova karakterizacija]]></title_hr><title_en><![CDATA[Chromatographic purification of biomolecules and their characterization]]></title_en><user_id>111</user_id><user_firstLast_name>Marija Brgles</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2013-11</proposal_call><code>UIP-2013-11-8193</code><acronim><![CDATA[CHROBIO]]></acronim><duration>15.09.2014 - 14.09.2017</duration><status>Završio</status><financ_value>89.765,81 eur</financ_value><scie_area_hr>Prirodne znanosti, Biomedicina i zdravstvo, Biotehničke znanosti, </scie_area_hr><scie_area_en>Natural sciences, Biomedicine and health sciences, Biotechnical sciences, </scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu]]></institution_hr><institution_en><![CDATA[University of Zagreb]]></institution_en><team_members_id>3085, 1144, 3357, 102, 936, 17755, </team_members_id><team_members_names><![CDATA[Jelena Ivančić Jelečki, Tihana Kurtović, Maja Markušić, Beata Halassy, DUBRAVKO FORČIĆ, Dora Sviben, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[chromatography, viruses, plasma proteins, snake venom, monoliths, bioanalytics, aggregation]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Aim of the proposed research is the design of non-invasive chromatographic methods suitable for purification and concentration of biomolecules (viruses and proteins) and their characterization. Purification and analysis methods will be focused on measles virus, snake venom and antivenom proteins, and human plasma proteins. Measles virus is used as a vaccine and is found very suitable as a gene vector and as an oncolytic virotherapeutic, with the last two applications requiring large amounts of the virus. Venom is an antigen for antivenom production and both require careful analysis in order to obtain the final product of high quality. Proteins from plasma, namely albumin and immunoglobulin, are of great medical importance and their purification and stability are of utmost significance. All these biomolecules are important as biotechnological products and are subjected to rigorous quality requirements to ensure their safe usage. Therefore, non-invasive purification methods upgrading their quality and sustainable production and ensuring stability of these fragile biomolecules are essential. This project will base purification on chromatography using monolith stationary phases which are featured by their suitability for biomolecules due to high porosity, high binding capacity and convective based transport. Ion-exchange and affinity chromatography will be employed and various conditions tested for obtaining target material with high purity and yield. Also, various formulation conditions enabling preservation of virus viability and protein functionality and stability throughout the process will be tested. The analysis of the virus infectivity and protein functionality, removal of contaminants and the overall procedure effectiveness will be done by classical biochemical and virological methods as well as by some novel methods such as nanoparticle analysis that enables detection of virus and protein aggregates (NanoSight).]]></summary_en></project><project>
<id>1879</id><title_hr><![CDATA[Povezanost fleksibilnosti, aktivnosti i strukture u porodici dipeptidil-peptidaza III]]></title_hr><title_en><![CDATA[Flexibility, activity and structure correlations in the dipeptidyl peptidase III family]]></title_en><user_id>2974</user_id><user_firstLast_name>Sanja Tomić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-7235</code><acronim><![CDATA[FlAcS]]></acronim><duration>01.07.2014 - 31.10.2017</duration><status>Završio</status><financ_value>86.741,12 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>5071, 2975, 56, 3310, 2700, 2638, 1522, 1429, 4619, 17832, </team_members_id><team_members_names><![CDATA[Marija Abramić, Antonija Tomić, Borislav Kovačević, Saša Kazazić, Dejan Agić, Igor Sabljić, Zrinka Karačić, Nina Jajčanin Jozić, Mihaela Matovina, Marko Tomin, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[dipeptidyl peptidase III, metallopeptidase, catalytic activity, protein flexibility, MD simulations, QM/MM, H/D exchange, protein interactions]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Within the project frame we intend to investigate diversity in evolutionary conserved metallopeptidase family M49 (DPP III family) through characterization of catalytic, structural and dynamical properties of its members. The project would encompass five dipeptidyl peptidases III (DPP III): human, yeast, two bacterial orthologs, from thermophile Caldithrix abyssi and oral pathogen Porphyromonas gingivalis, and a DPP III from plant Physcomitrella patens. The DPP III cleaves dipeptides from the N-terminus of many oligopeptides and contributes to the intracellular protein metabolism as well as to endogenous defense against oxidative stress. Human DPP III (h.DPP III) is also related to pathological processes of cataractogenesis, tumor growth and influenza virus infection. The project research should elucidate whether the large flexibility determined for h.DPP III is conserved within DPP IIIs, and how it correlates with the protein function. It would reveal submolecular details important for substrate stabilization and, in the case of h.DPP III, the enzymatic mechanism. Elucidation of the key interactions between h.DPP III and Keap1 protein (Nrf2-Keap1 signalling pathway is major regulator of cytoprotective responses to oxidative and electrophilic stress), and possible correlation of DPP III flexibility with the complex stability, should aid in clarification of its cellular roles. Plant DPP III, differently from DPP IIIs in other organisms possesses a NUDIX box. The project should elucidate its potential dual activity (peptidase and NUDIX). Study of DPP III from thermophile should improve our knowledge on thermophile proteins, potentially useful in biotechnology. In order to fulfill the outlined goals a finely tuned multidisciplinary approach would be used in which molecular biology, biochemistry and mass spectrometry methods would be complemented with bioinformatics, multiscale molecular modeling (coarse grained/all atom MD, QM/MM) and macromolecular crystallography.]]></summary_en></project><project>
<id>1880</id><title_hr><![CDATA[Proteomski pristup otkrivanju biomarkera ranog oštećenja bubrega i srca u pasa]]></title_hr><title_en><![CDATA[Proteomic approach in the discovery of early-stage biomarkers in kidney and cardiac disease of dog]]></title_en><user_id>801</user_id><user_firstLast_name>Vladimir Mrljak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-4135</code><acronim><![CDATA[BioDog]]></acronim><duration>01.07.2014 - 30.06.2018</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Veterinarska medicina, </scie_field_hr><scie_field_en>Veterinary medicine, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Veterinarski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Veterinary Medicine]]></institution_en><team_members_id>3369, 6678, 4117, 6240, 4115, 6598, 6734, 2720, 6965, 6338, 5882, 2601, 6943, 6501, 17792, 19055, 2779, 19049, 19047, </team_members_id><team_members_names><![CDATA[Vesna Matijatko, Martina Crnogaj, Mirna Brkljačić, Jelena Selanec, Marin Torti, Živičnjak Tatjana, Josipa Kuleš, Blanka  Beer Ljubić, Renata Barić Rafaj, Jose Ceron, Alan Kovacevic, Srđan Vučinić, Carlos de Torre, Mazzucchelli Gabriel, Petra Nižić, Mangesh Bhide, Anita  Horvatić, Asier Galan, Guillemin Nicolas, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[biomarkers, dog, proteomics, kidney, heart, babesiosis, idiopathic dilated cardiomyopathy, chronic valvular disease]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Proteins play essential roles in every cellular process. Biomarkers have the potential to identify key disease indicators at the individualised level, as well as to detect a disease at the early-stages before the development/advance of a serious illness. The emergence of innovative, post-genomic technology, like proteomics, led to the development of strategies aimed at identifying altered, sensitive biomarkers specific to the disease among thousands of molecules present in biological samples. Blood and urine contains multitude, unstudied, and unknown biomarkers, particularly in low-molecular region of blood and urine proteome. Babesiosis, idiopathic dilated cardiomyopathy (iDCM), and chronic valvular disease (CVD-MV) in dogs are common and serious disease. The aims of the project is: to discover novel, early-stage biomarkers of kidney and cardiac disease in dogs which could lead toward more precise and adequate diagnose, prognosis, and monitoring of these diseases; to perform a proteomic analysis on the sera and urine of dogs with uncomplicated and complicated form of babesiosis, as well as dogs with diagnosed iDCM and CVD-MV in order to identify novel, early-stage diagnostic and prognostic biomarkers; to expand the pathway signalling research in order to improve the understanding of pathogenesis for studied disease; to validate new biomarkers for studied diseases.  Tthese expected scientific outcomes will contribute in practice: (a) in a short term view, to detect individualised molecular fingerprints; to improve the diagnosis and prognosis of iDCM, CVD-MV, and babesiosis, as well as potential targets for novel approaches to monitor the therapies of these diseases; to enable the ability to personalise the treatment of individual patients resulting in enhanced patient care; and (b) in a long-term view, to allow entry of proteomics in clinical veterinary medicine in Croatia and transfer of knowledge in –omics- technologies in other parts of veterinary medicine.]]></summary_en></project><project>
<id>1884</id><title_hr><![CDATA[Jadranske geopolitike u modernosti, 1493.-1914.]]></title_hr><title_en><![CDATA[The Modern Geopolitics of the Adriatic Sea, 1493-1914]]></title_en><user_id>5171</user_id><user_firstLast_name>Josip Vrandečić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-8469</code><acronim><![CDATA[Megas]]></acronim><duration>01.07.2014 - 30.06.2018</duration><status>Završio</status><financ_value>17.373,42 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Povijest, </scie_field_hr><scie_field_en>History, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>5524, 6986, 2763, 5570, </team_members_id><team_members_names><![CDATA[Nikša Varezić, Edi Miloš, Marko Trogrlić, Marko Rimac, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Imperio Maris Adriatici, Heartland, Venice, Austria, Ottoman Empire, Napoleon, Irredentism]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The project aims to draw attention to the foreign politics and the military build-up of the great and middle powers at the Adriatic during the both early modern period and the 19th century. The starting point of the study is the Ottoman occupation of Bosnia in 1463 confirmed by defeat of Croatian army in the Battle of Krbava in 1493. The main allies of anti-Ottoman resistance Habsburgs, Venice and the popes sought to prevent the Ottoman penetration to the Adriatic and in the West. In their long term efforts they used tools of military revolution that has prevailed on their side. However, the early modern alliance is marked by a profound Habsburg-Venetian rivalry on the Adriatic which was ended by the fall of Venice in 1797 year. A new contender at the Adriatic, the revolutionary France, sought to repel Russians and Britons, and to provide a springboard to the East. After the fall of Napoleon, Austria secured supremacy on the sea, but the newly proclaimed Kingdom of Italy continued the centuries-long conflict over the Adriatic. In addressing the historical prospective, the project focuses on publishing five books which will present each phase of the competition and the main protagonists in this conflict.     1. Josip Vrandečić, The Adriatic Mission Zadar of Minuccio Minucci, the Archbishop of Zadar, 1596-1604. 2. Nikša Varezić, Republic of Dubrovnik and the Holy See, 1645-1699. 3. Marko Rimac, The Cetina region between Ottoman and Venetian rule (1683-1730). 4. Marko Trogrlić-Josip Vrandečić, Reports of Dalmatian Governor Vincenzo Dandolo to Emperor Napoleon, 1806-1809. 5. Marko Trogrlić, Memoirs of the Dalmatian Governor General Gabriel Rodić, 1812-1890. ]]></summary_en></project><project>
<id>1895</id><title_hr><![CDATA[Raznolikost i interakcije kestena, patogene gljive koja izaziva rak kestena i virusa koji inficira gljivu: učinak na oporavak kestena]]></title_hr><title_en><![CDATA[Diversity and interactions of chestnut, chestnut blight fungus and biocontrol agent – virus: implications on chestnut recovery]]></title_en><user_id>761</user_id><user_firstLast_name>Mirna  Ćurković Perica</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-5381</code><acronim><![CDATA[Chestnut]]></acronim><duration>30.06.2014 - 29.06.2017</duration><status>Završio</status><financ_value>98.944,85 eur</financ_value><scie_area_hr>Biotehničke znanosti, Prirodne znanosti, </scie_area_hr><scie_area_en>Biotechnical sciences, Natural sciences, </scie_area_en><scie_field_hr>Šumarstvo, </scie_field_hr><scie_field_en>Forestry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>975, 4710, 1532, 1336, 2565, 757, 2506, 1456, 17770, 19883, </team_members_id><team_members_names><![CDATA[Marilena Idžojtić, Mirta Tkalec, Ljiljana Krstin, Daniel Rigling, Rosemary Vuković, Igor Poljak, Marin Ježić, Zorana Katanić, Lucija Nuskern, Jelena Mlinarec Novosel, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[biological control, chestnut disease, epigenetics, hypovirulence, molecular ecology]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[European sweet chestnut is an important multipurpose tree species. For decades, chestnut blight, a disease caused by one of the world´s most aggressive invasive pathogens Cryphonectria parasitica has been causing high mortality in chestnut forest populations and orchards. However, the fungus can be controlled by the naturally-occurring virus Cryphonectria hypovirus 1 (CHV1) which causes a reduction in fungal virulence and sporulation (a phenomenon called hypovirulence), which in turn enables infected trees to recover. Hypovirulence is the most efficient way to successfully control chestnut blight in Europe, but unfortunately the spread of CHV-1 is limited by the fungal diversity and its sexual reproduction. This project aims at revealing individual and joint aspects of the dynamic three-lateral interaction between chestnut, its fungal pathogen and the pathogen-biocontrol agent-virus. The proposed study will: (1) reveal the diversity of natural chestnut populations in south-eastern Europe, (2) connect the sequences and 3-D structures of CHV1 subtype I proteins with the level of fungal hypovirulence, (3) reveal the role of epigenetic changes of fungal genome in respect to hypovirus infection and geographical spread of the fungus (4) assess the efficiency of naturally-occurring virus isolates to induce chestnut recovery in natural conditions. The results will also contribute to the combat efforts against chestnut blight in the field conditions, by enabling production of therapeutic paste for induction of recovery in a valuable chestnut cultivar.]]></summary_en></project><project>
<id>1901</id><title_hr><![CDATA[Očuvanje genofonda šumskog drveća u svjetlu klimatskih promjena]]></title_hr><title_en><![CDATA[Conservation of genetic resources of forest trees in light of climate changes]]></title_en><user_id>5275</user_id><user_firstLast_name>Mladen Ivanković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-8131</code><acronim><![CDATA[ConForClim]]></acronim><duration>01.09.2014 - 31.08.2018</duration><status>Završio</status><financ_value>111.487,16 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Šumarstvo, </scie_field_hr><scie_field_en>Forestry, </scie_field_en><institution_hr><![CDATA[Hrvatski šumarski institut]]></institution_hr><institution_en><![CDATA[Croatian Forest Research Institute]]></institution_en><team_members_id>5744, 5235, 5716, 5607, 17850, 12638, 44, 20996, 21001, 13263, </team_members_id><team_members_names><![CDATA[Sanja Novak Agbaba, Nevenka Ćelepirović, Marija Gradečki-Poštenjak, Maja Popović, Sanja Mrmić, Ivica Čehulić, Saša Bogdan, Netzer Florian, Anđelina Gavranović, Aikaterini Dounavi, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Genetic conservation, Climate changes, Forest , provenance trials, variability, Quercus robur, Fagus sylvatica ]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The preserving of the genetic diversity of the forest types is the basis for sustainable management and conservation of the natural composition of the forests. Natural forests make up 95% of the total forests in Croatia and in its wealth geographic region contains different ecological types and a large number of the forest tree species. Global climate changes, rising temperatures, falling rainfall, occurrence of the extreme weather events directly affect on genetic diversity. The main objective of the proposed project is to make recommendations for the conservation of the genetic diversity of the forest trees. Precondition for achieving the goal is the identification and understanding of the genetic variability of the individual tree species. The research to be carried out by the project would be based on the common oak and beech. On existing genetic tests that were established at different sites, data on the survival and growth of plants, phenology, silvicultural properties, plant resistance to pests, etc should be collect. The stem forest stands from which the seed was taken will be used for collecting the data of health condition, fruiting and climatic parameters. The genetic diversity of the provenance will be analyzed by DNA markers. This project should be continued and expanded research on the identification of proven European beech resistant to drought, which are conducted in the framework of a bilateral cooperation with Germany (MSES-DAAD 2013/14) and the preservation of the gene pool and study of the variability of our most important tree species which are conducted as part of the project “Breeding and forest seed” supported by MSES of Croatia. From the economic point of view, the project aims is to raise the category of the forest reproductive material (FRM) in a higher category according to the Law of FRM (Official Gazette 75/2009, 61 /2011 - EU directive EC/105/99). Higher category guarantees a higher quality, and thus a higher price in the market.]]></summary_en></project><project>
<id>1911</id><title_hr><![CDATA[Rekombinacija, popravak DNA i očuvanje integriteta genoma: novi putevi]]></title_hr><title_en><![CDATA[DNA recombination, repair and maintenance of genome integrity: new pathways]]></title_en><user_id>5202</user_id><user_firstLast_name>Davor Zahradka</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-2978</code><acronim><![CDATA[RECNEWPATH]]></acronim><duration>01.09.2014 - 31.12.2018</duration><status>Završio</status><financ_value>131.125,64 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>5240, 5308, 5923, 5816, 5340, 5343, 5910, </team_members_id><team_members_names><![CDATA[Ksenija Zahradka, Damir Đermić, Dušica Vujaklija, Miroslav Radman, Jelena Repar, Svjetlana  Cvjetan, Tina  Paradžik, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[hommologous recombination, DNA repair, genome stability, Escherichia coli, Deinococcus radiodurans, RecA protein, gross chromosomal rearrangements]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Homologous recombination is an essential biological process that is involved in DNA repair and in the maintenance of genome integrity. The RecA protein is a key component of recombinational systems in bacteria. Its homologs are also present in higher organisms including humans. RecA functions in the form of nucleoprotein filaments that are assembled on single-stranded DNA, and which catalyze pairing and strand exchange between two homologous DNA duplexes. In Escherichia coli, the RecBCD and RecFOR protein complexes mediate RecA filament assembly, and consequently, play an important role in recombination. We have recently discovered that some E. coli mutants recombine quite efficiently in the absence of both RecBCD and RecFOR complexes. This recombination is RecA-dependent suggesting the existence of an alternative RecA loading activity. The aim of the project is to genetically characterize this RecBCD- RecFOR-independent (RecBFI) recombination pathway, and gain insight into this novel mechanism of RecA filament assembly. Although RecA is crucial for efficient recombination in bacteria, the recA mutants of radiation-resistant bacterium Deinococcus radiodurans display a significant residual ability to repair double-strand DNA breaks. Recent results from our group have shown that this RecA-independent repair is quite inaccurate leading to gross chromosome rearrangements. Our project is to identify the key genes/proteins involved in this RecA-independent repair, and to characterize, at the sequence level, gross genome rearrangements in D. radiodurans. Given that recombination is a fundamental process largely conserved during evolution, our research on bacteria may reveal molecular mechanisms that are applicable to eukaryotic recombination systems. Thus, the results of our project could be instructive for research on cancer and other human hereditary diseases related to defects in DNA recombination functions. ]]></summary_en></project><project>
<id>1912</id><title_hr><![CDATA[Detekcija objekata više razreda za pametna vozila i sigurnije ceste]]></title_hr><title_en><![CDATA[Multi-class object detection for smart vehicles and safer roads]]></title_en><user_id>361</user_id><user_firstLast_name>Siniša Šegvić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-1395</code><acronim><![CDATA[MULTICLOD]]></acronim><duration>01.10.2014 - 30.09.2017</duration><status>Završio</status><financ_value>93.538,64 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>6558, 6564, 6565, 6914, 6351, 6700, 6984, 7053, 7393, </team_members_id><team_members_names><![CDATA[Josip Krapac, Zoran Kalafatić, Ivan Krešo, Axel Pinz, Marko Ševrović, Valentina Zadrija, Domagoj Jakobović, Ivan Sikirić, Albert  Diosi, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Computer vision, structure from motion, object detection, image categorization, multi-body structure from motion]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Throughout the last decades we witness persistent improvement in understanding ways to make machines see. Consequently, opportunities for computer vision applications are becoming more and more abundant. Understanding dynamic traffic scenes is especially interesting due to exciting applications in the fields of smart vehicles (driver assistance, autonomous cars) and intelligent transportation systems (road safety inspection, adaptive traffic control). Nevertheless, many of these applications are out of reach since the computers are still unable to match human perception. We believe that this gap would be reduced by improving our understanding of scalable detection of multiple object classes in dynamic scenes.The task of object detection is to localize objects of interest in input images. We address detection in the most general case where the objects of interest exhibit large appearance variation. In this case the problem is often referred to as multi-class object detection. Our proposal focuses on dynamic traffic scenes acquired by a calibrated stereo rig from the driver&#39;s perspective. We propose to develop detection approaches which would combine estimated camera motion and scene structure with learned appearance features, and to experimentally compare them with the state of the art. We shall employ advanced methodologies such as SfM, dense stereo, variational optimization, scene flow, spatio-temporal descriptors, latent SVM and Fisher vectors. These methodologies shall enable us to achieve improvements upon the state of the art in terms of scalability and detection performance. This will open way to exciting applications capable of reducing traffic accidents, improving efficiency and decreasing traffic congestion. Some of these applications shall be demonstrated by experiments on a real autonomous car. The proposed research would also contribute to a future unified theory of computer vision which would encompass detection, reconstruction and categorization.]]></summary_en></project><project>
<id>1915</id><title_hr><![CDATA[Biološki učinci vina: utjecaj vinifikacijske tehnologije, dealkoholizacije i starenja vina]]></title_hr><title_en><![CDATA[Biological effects of wine: the influence of vinification technology, dealcoholization and aging of wine]]></title_en><user_id>2679</user_id><user_firstLast_name>Mladen Boban</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-8652</code><acronim><![CDATA[BioWine]]></acronim><duration>01.09.2014 - 31.08.2019</duration><status>Završio</status><financ_value>132.466,75 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo, Biotehničke znanosti, </scie_area_hr><scie_area_en>Biomedicine and health sciences, Biotechnical sciences, </scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Split School of Medicine]]></institution_en><team_members_id>3385, 4348, 3112, 5297, 3823, 3690, 2542, 809, 3346, 3068, 3048, 21325, 12573, 24315, </team_members_id><team_members_names><![CDATA[Ivica Grković, Natalija Filipović, Jungbauer Alois, Višnja Katalinić, Danijela Skroza, Vlado Krauthaker, Ivana Mudnić, Nikolina Režić Mužinić, Ana Šešelja Perišin, Nataša Boban, Josip Volarević, Ana Marija Milat, Benjamin Benzon, Danica Ivanković, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[wine, wine technology, cardiovascular, antimicrobial, anti-inflammatory, antioxidant]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Grape production technology and procedures in wine making and processing significantly affect biochemical composition and organoleptic properties of wine. However, the effects of different enological procedures on biological activity of wine are poorly investigated.The overall aim of this project, which represents an interdisciplinary research effort of experts from fields of biotechnology and biomedicine, is to investigate how different enological procedures in wine making (changes of maceration time, partial/complete dealcoholization, aging of wine) may affect its biological activity. This also includes investigation of potential differences in distinctive biological effects between wines obtained by the technology of white and red wine production.In contrast to the process of red wine production, in the white wine production there is no maceration in contact with grape seeds and skins, and only fermentation of immediately separated grape juice occurs. So, biological potentials of white wines may considerably differ from that of red wines. Conversely, if even short maceration is allowed in the process of white wine making, polyphenolic content and antioxidant potential of such wines is significantly enhanced. There are several studies demonstrating superior effects of red versus white wine on certain cardiovascular parameters. However, epidemiological evidence demonstrating specific benefits of red over white wine is poor and conclusive studies comparing the two are missing.Detailed biochemical analyses of all test wines will be performed and their biochemical properties will be correlated with their biological activity.Among numerous biological effects of wine and its constituents, this project focuses on cardiovascular, antioxidative, anti-inflammatory and antibacterial effects of wine that will be examined on a spectrum of in vitro and in vivo biological systems including small laboratory animals and human volunteers.]]></summary_en></project><project>
<id>1924</id><title_hr><![CDATA[Numeričko modeliranje složenih elektromagnetskih pojava u transformatorima]]></title_hr><title_en><![CDATA[Numerical Modelling of Complex Electromagnetic Phenomena in Transformers]]></title_en><user_id>312</user_id><user_firstLast_name>Željko Štih</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-1118</code><acronim><![CDATA[NM_TRAF]]></acronim><duration>01.08.2014 - 31.07.2018</duration><status>Završio</status><financ_value>122.273,20 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>314, 2877, 328, 319, 1117, 1373, 324, 2797, 2823, 2777, 2712, 2792, 4947, 4355, </team_members_id><team_members_names><![CDATA[Sead Berberović, Livio Šušnjić, Martin Dadić, Bojan Trkulja, Žarko Janić, Dalibor Filipović-Grčić, Tomislav Župan, Robert Sitar, Mladen Marković, Kosjenka Capuder, Franjo Kelemen, Igor Žiger, Goran Plišić, Ivan Šulc, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[numerical methods, transformers, insulation systems, lossess, high frequency modelling]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Transformers are crucial devices in efficient and reliable transmission and distribution of electricity. Croatian transformer manufacturers are among a top few in the world, and their annual production is worth about €300 million, what is about 2% of the world production. It is possible to keep this position on the world market only if there is a close collaboration between the academic community and transformer manufacturers. Notable progress in technology of transformers is based on utilization of new materials and application of advanced design methodologies, which incorporate sophisticated numerical methods for modelling of processes in transformers. This project is focused on research and development of advanced numerical techniques for solving various electromagnetic phenomena in transformers and their application in design. Crucial subjects in transformer design are: insulation system, electromagnetic losses and windings. Consequently, researches within this project are organized in three subprojects:1.	New methods for design of insulating systems. The aim of this subproject is to develop new comprehensive numerical method for computation of electric fields within the insulating system.2.	Computation of electromagnetic losses with the aim to develop a new method of estimation of stray losses level of power transformer, as well as the methodology of simultaneous modelling of electromagnetic field, thermal field and fluid dynamics field in transformers.3.	High frequency modelling of windings. The objective of this subproject is to develop fast and accurate procedures for the determination of capacitances, inductances and resistances in high-frequency range. These elements will be used for creating an equivalent lumped-element circuit for determination of voltage stresses along a winding.The overall goal is to reduce dimensions of transformers and to increase their reliability by application of new methods and procedures. ]]></summary_en></project><project>
<id>1942</id><title_hr><![CDATA[Matematičko modeliranje, analiza i računanje s primjenama na kompleksne mehaničke sustave]]></title_hr><title_en><![CDATA[Mathematical modelling, analysis and computing with applications to complex mechanical systems]]></title_en><user_id>2945</user_id><user_firstLast_name>Zlatko Drmač</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-9345</code><acronim><![CDATA[MMACACMS]]></acronim><duration>01.09.2014 - 31.08.2018</duration><status>Završio</status><financ_value>77.606,72 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>4557, 5056, 4816, 5431, 4757, 17823, </team_members_id><team_members_names><![CDATA[Luka Grubišić, Zvonimir Bujanović, Josip Tambača, Ivica Nakić, Nela Bosner, Ivana Šain, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[scientific computing, complex mechanical systems, eigenvalue problems, model reduction, distributed control, high perfomance scientif computing]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[This proposal is focused on functional and numerical analysis of mathematical models of selected complex mechanical systems from mathematical physics and engineering, with particular emphasis on the development of numerical methods and robust algorithms for computing. Such operator theoretic models are particularly amenable to be treated algebraically in the context of efficient and robust computational procedures of modern numerical linear algebra. The themes include adaptive (interior penalty) discontinuous Galerkin method in the penalty based formulation of the model for the complex mechanical system (e.g. stent), and vibration analysis for powertrains (car industry).  In a related topic of vibration control, we study distributed control using dynamic multipliers from the dissipativity theory.  In the frequency domain, we consider the problems of system identification and model order reduction posed as problems of rational approximation in the Hardy space H2. For all considered problems, we devise numerical algorithms and identify core numerical linear algebra computational tasks for which we plan to develop robust algorithms. These include Arnoldi-type eigensolver for both linear and quadratic large scale eigenvalue problems, and high accuracy algorithms for structured matrices of paired Cauchy structure. All developed algorithms will be delivered also as high performance mathematical software.]]></summary_en></project><project>
<id>1945</id><title_hr><![CDATA[Epigenetička regulacija glikozilacije immunoglobulina G]]></title_hr><title_en><![CDATA[Epigenetic regulation of IgG glycosylation]]></title_en><user_id>5416</user_id><user_firstLast_name>Vlatka Zoldoš</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-3361</code><acronim><![CDATA[EpiGlycoIgG]]></acronim><duration>01.10.2014 - 30.09.2018</duration><status>Završio</status><financ_value>132.034,67 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>5420, 5620, 5359, 5449, 5468, 5425, 5596, 5428, 5952, 17847, 1497, </team_members_id><team_members_names><![CDATA[Gordan Lauc, Aleksandar Vojta, Ivana Samarzija, Paula Dobrinić, Marija Klasić, Dora Markulin, Vedrana Vičić Bočkor, Genadij Razdorov, Toma Keser, Vanja Tadić, Petra Korać, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[DNA methylation, Epigenetics, Histone modifications, IgG, Protein glycosylation, TALENS]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[IgG is one of the main effectors of the immune system. Contrary to antigen binding properties which are defined by nucleotide sequence for its Fab part, effector functions of IgG are mostly regulated by Fc glycosylation, which is regulated by complex interplay of dozens of genes in the IgG glycosylation pathway and different environmental factors. Different clones of B lymphocytes have defined patterns of glycosylation, indicating temporal stability in the glycosylation pathway. DNA CpG methylation is the most stable epigenetic modification and is thus the most prominent candidate for “fixation” of the IgG glycosylation profile in different clones. Our past and current genome wide association studies (GWAS) are identifying complex genetic network which regulates IgG glycosylation. In this project we will use several complementary experimental approaches to identify genes and epigenetic regulatory mechanisms which regulate IgG glycosylation. IgG glycosylation is relevant in numerous diseases, including autoimmune diseases, inflammatory diseases and cancer. Several epigenetic drugs are already used to treat cancer, and many others are developing. Understanding of the role of the epigenetic regulation in IgG glycosylation will provide new targets for the development of new epigenetic drugs and new biomarkers for patient stratification. ]]></summary_en></project><project>
<id>1950</id><title_hr><![CDATA[Pogrebni običaji i društvo kasnog brončanog doba na jugu Karpatske kotline]]></title_hr><title_en><![CDATA[Late Bronze Age mortuary practices and society in southern Carpathian Basin]]></title_en><user_id>3646</user_id><user_firstLast_name>Daria Ložnjak Dizdar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2013-11</proposal_call><code>UIP-2013-11-5327</code><acronim><![CDATA[BAMPICa]]></acronim><duration>01.07.2014 - 30.06.2017</duration><status>Završio</status><financ_value>77.908,29 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Arheologija, </scie_field_hr><scie_field_en>Archeology, </scie_field_en><institution_hr><![CDATA[Institut za arheologiju]]></institution_hr><institution_en><![CDATA[Institute of Archaeology in Zagreb]]></institution_en><team_members_id>5790, 7071, 7061, 1371, 7110, 7022, 7601, </team_members_id><team_members_names><![CDATA[Petra Rajić Šikanjić, Marko Dizdar, Stašo  Forenbaher, Zrinka Premužić, Boris Kavur, Carola Metzner-Nebelsick, Marie Louise Stig Sorensen, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Late Bronze Age, mortuary practices, society,  archaeology, anthropology, southern Carpathian Basin]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[This project proposes to combine archaeology and physical anthropology in order to expand the current knowledge of Late Bronze Age (LBA) mortuary practices and society in Carpathian Basin. It will integrate analyses of burial features and associated artifacts with analyses of cremated human remains from at least seven urnfield cemeteries in northern Croatia, dated between 13th and 9th century BC. We shall seek correlations between skeletal and artifactual evidence, which should allow us to recognize regularities and possible discrepancies linked to a specific gender or age group. Our primary aim is to investigate the variability of mortuary practices as reflected in modes of corpse treatment and disposal. At a more general level, we shall combine our data in order to investigate LBA social identities in southern Carpathian Basin. Our second aim is to investigate whether the traditionally perceived difference between &#39;Urnfield culture&#39; and &#39;Belegiš II group&#39; can be detected in mortuary evidence other than urns. Our sample of 120 burials covers a time span of six centuries, which will allow us to monitor the diversity of mortuary practices during the entire LBA and also contribute to the resolution of regional chronology. In order to archive the data, as well as to distribute and promote our findings, we shall design a public-access data base, organize a round table with experts from region and publish our results in a monograph.]]></summary_en></project><project>
<id>1955</id><title_hr><![CDATA[Formacija i destrukcija domena u vodenim otopinama]]></title_hr><title_en><![CDATA[Multi-scale description of meso-scale domain formation and destruction]]></title_en><user_id>5374</user_id><user_firstLast_name>Larisa Zoranić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2013-11</proposal_call><code>UIP-2013-11-4514</code><acronim><![CDATA[MS-FORMDES]]></acronim><duration>15.09.2014 - 14.12.2017</duration><status>Završio</status><financ_value>75.375,93 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Science]]></institution_en><team_members_id>5591, 5569, 6896, 1469, 3589, 6868, 19038, 19062, </team_members_id><team_members_names><![CDATA[Bernarda Lovrinčević, Martina Požar, Marijana  Mijaković, Franjo Sokolić, Nada Ilić, Aurelien Perera, Yogesh Sonavane, Tomislav Primorac, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[associated liquids, micro-heterogeneity, molecular dynamics, integral equation theory, antimicrobial peptides]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The physics of associated liquids, amphiphilic solutions and lipids in water is determined by competing hydrophobic and hydrophilic interactions between various molecular groups. By exploring assemblies ranging from molecular to cellular sizes we are aiming at  building a unified view of the principal mechanisms responsible for domain formation and destruction. This new approach hasn&#39;t been explored as such in similar research projects. In the project&#39;s first year, by molecular dynamic simulations, we will quantify micro-heterogeneity in liquids as a structural order that exists on the local scale and doesn&#39;t propagate on the global scale. As a continuation of the first-year results, we will study how the structure of the above mentioned liquids changes when dissolving molecules that promote or destroy domains defined by the local ordering. The used methods will be simulations and integral equation theory. In parallel with the molecular scale studies, the cellular membranes will be probed by means of experimental measurements and simulations. The aim will be to describe the mechanism of destruction of lipid bilayers induced by antimicrobial peptides. Principal investigator Larisa Zoranić has competencies to establish a new research group with an interdisciplinary subject and members of diverse fields because of her scientific background in physics, biology and biophysics. She has experience working in both international and Croatian groups, thus obtaining the required managing skills. The group&#39;s acquired knowledge and expertize will ensure a good quality start towards more demanding issues that stem from the project. The aims and methods of this research are competitive internationally in the area of molecular physics and biophysics. This kind of innovative project, built around an interdisciplinary group and having strong connections with the diploma and doctorate studies, will strengthen the Croatian scientific network.]]></summary_en></project><project>
<id>1982</id><title_hr><![CDATA[Napredni tekstilni materijali dobiveni ciljanom modifikacijom površine]]></title_hr><title_en><![CDATA[Advanced textile materials by targeted surface modifications]]></title_en><user_id>747</user_id><user_firstLast_name>Sandra Bischof</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-9967</code><acronim><![CDATA[ADVANCETEX]]></acronim><duration>01.09.2014 - 31.01.2019</duration><status>Završio</status><financ_value>131.289,40 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Tekstilna tehnologija, </scie_field_hr><scie_field_en>Textile technology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Tekstilno-tehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Textile Technology]]></institution_en><team_members_id>3887, 3088, 1464, 4810, 5211, 5841, 1504, 1494, 1466, 1481, 7190, 17700, 15905, 17701, 17882, 17882, </team_members_id><team_members_names><![CDATA[Edita Vujasinović, Anita Tarbuk, Ružica Brunšek (Šurina), Tihana Dekanić, Sandra Flinčec Grgac, Tanja Pušić, Marijana Pavunc, Zorana Kovačević, Ana Budimir, Branka Vojnović, Branka Marinovic, Iva Matijević, Eva Magovac, Ana Sutlović, Suzana Kutnjak-Mravlinčić, Suzana Kutnjak-Mravlinčić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[advanced materials, textiles, surface modification, fibre reinforced composites, nano-metal particles, LCA, ]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The demand for advanced textile materials has dramatically increased during the last few decades, in particular for engineering, medical and technical applications. A new sight proposed by this project is in the merging of so far separate research teams involved in the development of advanced textile materials, through targeted eco-driven surface modifications. Surface pre-treatments and modification will be carried out on selected sustainable textile materials, using environmentally friendly substances and processes, in order to attain antimicrobial, flame retardant, oil/hydrophobic, wellness or medical properties obtaining high added value textiles. Different environmentally friendly methods of microwave, ultrasound or plasma modification processes will be used to enhance targeted functionalities as well as to increase interfacial adhesion between fibres and polymer matrix in fibre reinforced composites. The other approach of the production of highly active surfaces which will have capability to block UV and microwave radiation, enhance oil and water repellence, antimicrobial, self-cleaning, and flame retardant properties is in the application of micro/nano-particles such as TiO2, ZnO, Cu, Ag and Au. These particles can be applied on the surface of fibers, textiles, clothing or inlayers for footwear. Detailed characterization of each treatment effectiveness, so as their effect on humans and the environment will be investigated. Laundering durability and maintenance properties are equally important as the effectiveness of developed advanced material. Introduction of novel eco-driven surface modification processes in textile production will be complemented by the risk analysis and sustainability issues, focusing onto production and product safety, usage and recyclability of newly developed product without significant environmental burden. Innovative textile products will be directed towards the needs of the textile, chemical, pharmaceutical or medical industries. ]]></summary_en></project><project>
<id>1984</id><title_hr><![CDATA[Diracovi operatori i teorija reprezentacija]]></title_hr><title_en><![CDATA[Dirac operators and representation theory]]></title_en><user_id>5573</user_id><user_firstLast_name>Pavle Pandzic</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-4176</code><acronim><![CDATA[representations]]></acronim><duration>01.06.2014 - 31.05.2018</duration><status>Završio</status><financ_value>82.462,99 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>5930, 5518, 6295, 5512, 5479, 5954, 17808, </team_members_id><team_members_names><![CDATA[Mladen Božičević, Hrvoje Kraljevic, Matija Bašić, Ksenija Kitanov, Rafael Mrđen, Ana Prlić, Karmen Grizelj, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Harish-Chandra modules, Dirac operators, cohomology, Dirac induction, branching problems]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Dirac operators were introduced into representation theory by Parthasarathy in the 1970s. In the 1990s, Vogan conjectured a strengthening of Parthasarathy&#39;s Dirac inequality, which relates the cohomology of the Dirac operator to the infinitesimal character of the representation. This conjecture was proved in a joint paper with Huang . In further research, in part joint with various collaborators (Barbasch, Huang, Kang, Mehdi, Protsak, Renard, Somberg, Zhu) , we related Dirac cohomology to other kinds of cohomology, calculated it explicitly for many interesting representations, and studied algebraic Dirac induction, a construction of representations with given Dirac cohomology. The proposed project will continue this research in several directions: 1) the study of representations obtained by Dirac induction, in particular the discrete series representations (doctoral research of Ana Prlić). 2) applying Dirac cohomology to problems of restricting representations. Some instances of this have been studied with Huang-Zhu and with Somberg. 3) trying to strengthen the Dirac inequality, which should have implications for the study of unitary representations. Some preliminary work on  the convex hull conjecture of Salamanca-Vogan has been done with Renard. 4) calculating the Dirac cohomology of  unipotent representations. Some cases of this have been obtained jointly with Barbasch. This could lead to better understanding of characters of unipotent representations, which is related to the Assem conjecture. It would also be interesting to calculate the Dirac cohomology of unitary highest weight modules. Other topics we plan to cover include studying translation principle for Dirac index (joint with Mehdi and Vogan); studying n-cohomology and BGG resolutions using Penrose transforms (joint with Soucek);  studying some abstract homotopy and homology theory, with applications to tensor categories of representations (doctoral research of Matija Bašić).]]></summary_en></project><project>
<id>1987</id><title_hr><![CDATA[Nastava i škola za net-generacije: unutarnja reforma nastave u osnovnim i srednjim školama]]></title_hr><title_en><![CDATA[School for Net-generation: Internal Reform of Primary and Secondary School Education]]></title_en><user_id>814</user_id><user_firstLast_name>Milan Matijević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-3814</code><acronim><![CDATA[SCHOOL 4 NET-GEN]]></acronim><duration>01.09.2014 - 31.08.2017</duration><status>Završio</status><financ_value>52.460,88 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Pedagogija, </scie_field_hr><scie_field_en>Pedagogy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Učiteljski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Teacher Education]]></institution_en><team_members_id>4771, 4809, 4729, 4127, 4126, 4874, 834, 3753, 3382, 18932, 18933, 18938, 18934, </team_members_id><team_members_names><![CDATA[Dubravka Miljković, Višnja Rajić, Mario Dumančić, Damir Velički, Vladimira Velički, Goran Lapat, Tomislav Topolovčan, Siniša Opić, Nevenka Maras, Lidija Eret, Željka Dijanić, Ivana Medica Ružić, Davorka Bačeković-Mitrović, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[digital media, internal reform, net-generation, parents, primary school, principals, secondary school, student centred education, teachers]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[In the last few years, research has shown that the teachers and methodologies in schools today are far from the expectations and needs of students belonging to the Net- Generation. The advantages offered by new digital and communication media are not sufficiently exploited to enhance communication in the classroom, and the course books available to students of elementary and secondary schools are not appropriate to the students&#39; needs and expectations. The main aim of the planned research is to explore the attitudes and (self-)evaluation of teachers, school principals (managers), parents and students about the specific traits of the existing didactical paradigm (teacher-centred education) that still dominates in Croatian schools, and to explore the possible didactical solutions for internal reform that focuses on student-centred education based on contemporary theories of teaching and learning and the possibility to enrich education with ICT.Empirical non-experimental, quasi-experimental, and action research is planned. The following methods of data collection will be used during the research: questionnaires, interviews, focus groups, systematic observation, case studies, and content analysis. A number of stratified student samples (N=3000), teacher samples (N=600) and school principals (N=300) from different counties in the Republic Croatia will be used for data collection. According to the general aim of the research and research problems, a number of research instruments (either constructed by the researchers or already verified) will be employed. In order to apply a holistic approach to the research area, qualitative and quantitative methodology will be used and triangulation will be applied for the purpose of ensuring quality in the data analysis. 	]]></summary_en></project><project>
<id>1991</id><title_hr><![CDATA[Implicitna ličnost i radno ponašanje]]></title_hr><title_en><![CDATA[Implicit personality and work behavior]]></title_en><user_id>3974</user_id><user_firstLast_name>Zvonimir Galic</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2013-11</proposal_call><code>UIP-2013-11-6719</code><acronim><![CDATA[IPAWB]]></acronim><duration>01.10.2014 - 30.09.2017</duration><status>Završio</status><financ_value>48.149,94 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Psihologija, </scie_field_hr><scie_field_en>Psychology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>4943, 4502, 5480, 5745, 6601, 6848, 4979, </team_members_id><team_members_names><![CDATA[Minja Birimiša Komazec, James LeBreton, Andreja Bubić, Maša Tonković Grabovac, Maja Parmač Kovačić, Željko Jerneić, Nataša Trojak, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[implicit personality, work behavior, conditional reasoning, aggressiveness, power motive.]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Recent developments in implicit personality conceptualization and measurement could shed a new light on the relationship between personality and work behavior and help us explain, predict, and even control important aspects of work behavior. In the focus of this project are conditional reasoning measures of implicit personality that represent “a model for psychometric, conceptual, and theory based implicit association measurement” (Landy, 2008, p. 390). This measurement system is called conditional reasoning because it is based on the assumption that an individual’s reasoning is conditional on his/her personality and that these differences in reasoning can be measured with inductive reasoning tasks capturing unconscious cognitive biases that stem from individuals’ personality motives.The project aims to further advance the knowledge about the conditional reasoning method of personality measurement, and the relationship between (implicit) personality and work behavior by exploring implicit aggression and power motive. We plan to (1) test the implicit nature of conditional reasoning tests and the strength of their relationship with other implicit personality measures intended to assess similar constructs; (2) further explore the relationship between the conditional reasoning tests and work behavior by testing mediators and moderators of that relationship; (3) study how different measures of implicit and explicit personality assessing the same construct (i.e., aggressiveness and power motive) interact in explaining work behaviors. We plan to focus on aggressiveness and power motive because they have the pivotal role in explaining very important aspects of work behavior such as counterproductive work behavior and leadership.]]></summary_en></project><project>
<id>1993</id><title_hr><![CDATA[Razvoj fotokatalitičkih polimernih nanokompozita za obradu otpadnih voda]]></title_hr><title_en><![CDATA[Development of Photocatalytic Polymer Nanocomposites for Wastewater Treatment]]></title_en><user_id>913</user_id><user_firstLast_name>Zlata Hrnjak-Murgić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-5092</code><acronim><![CDATA[DePoNPhoto]]></acronim><duration>01.09.2014 - 31.08.2018</duration><status>Završio</status><financ_value>121.481,19 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Kemijsko inženjerstvo, </scie_field_hr><scie_field_en>Chemical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet kemijskog inženjerstva i tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Chemical Engineering and Technology]]></institution_en><team_members_id>973, 1437, 1407, 3470, 5174, 17771, </team_members_id><team_members_names><![CDATA[Zvonimir Katančić, Ljerka Kratofil Krehula, Igor Peternel, Jadranka Travas-Sejdic, Mark Žic, Vanja Gilja, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[conducting polymers,  metal oxide nanoparticles, polymer nanocomposites, structure-properties relations, wastewater treatment]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Environmental problems associated with water pollution are an important issue correlated negatively with the health and ecosystem. The main goal of this proposal is to develop novel polymer nanocomposites of extending photoactivity toward visible region under UV/VIS light irradiation and to introduce an innovative technology for water purification. The conducting polymers (CPs) are known as good hole conducting materials1 and are combined with semiconductor nanoparticles to produce a synergistic effect and complementary properties. Due to that Polyaniline (PANI), polypyrrole (PPy) and poly(3,4-ethylene-dioxythiophene) (PEDOT) conducting polymers will be studied with metal oxides (TiO2, ZnO) nanoparticles to develop polymer nanocomposite photocatalysts (CPNPs) with enhanced photocatalytic properties. The optimal structure-properties relationships are crucial for efficient degradation of organic contaminants in water to convert them into harmless chemicals. Novel CPNPs will be applied in photocatalytic degradation of organic azo dyes (reactive red 45 and methyl orange) chosen as targeted wastewater pollutants. The utilization of waste material, fly ash, as a catalyst support will be explored to provide the additional environmental benefit. The proposed integral approach that will be used in the evaluation of the process efficiency will scrutinize any negative implications of CPNPs application. The project will contribute to the development and modernization of science and technology in Croatia, advancing toward the knowledge-based society within the European research area.Project includes a multidisciplinary effort, ranging from polymer science and technology, chemistry and environmental chemistry to electrochemical engineering, in order to meet challenging project tasks and propose an efficient photocatalytic polymer nanocomposite for sustainable water treatment technology. 1. M.R. Karim, C.J. Lee, Y.T. Park, M.S. Lee, J. Polym. Chem. 14 (2006) 5283–5290.]]></summary_en></project><project>
<id>2002</id><title_hr><![CDATA[Perspektive održivosti socijalne države: prema transformaciji sustava socijalne sigurnosti za pojedince u personaliziranoj medicini]]></title_hr><title_en><![CDATA[Perspectives of maintaining the social state: towards the transformation of social security systems for individuals in personalized medicine]]></title_en><user_id>5231</user_id><user_firstLast_name>Nada Bodiroga-Vukobrat</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-5709</code><acronim><![CDATA[POMTS]]></acronim><duration>29.12.2014 - 28.12.2018</duration><status>Završio</status><financ_value>76.016,25 eur</financ_value><scie_area_hr>Društvene znanosti, Biomedicina i zdravstvo, Biotehničke znanosti, </scie_area_hr><scie_area_en>Social sciences, Biomedicine and health sciences, Biotechnical sciences, </scie_area_en><scie_field_hr>Pravo, </scie_field_hr><scie_field_en>Law, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Pravni fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Law]]></institution_en><team_members_id>5119, 5585, 5367, 413, 5762, 6526, 6344, 6701, 6584, 6921, 6165, 2767, 3540, 7358, 7422, 6583, </team_members_id><team_members_names><![CDATA[Matija Miloš, Ana Pošćić, Sanja Barić, Vanja Smokvina, Adrijana Martinović, Dario Đerđa, Jelena Jardas Antonić, Nenad Vretenar, Marija Kaštelan Mrak, Marko Boban, Viktor Peršić, Krešimir Pavelić, Sandra Kraljević Pavelić, Jasmina Mutabžija, Martina Bajcic, Danijela Sokolić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[transition, social security system, biotechnologies, personalized medicine, reform of the social state]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Knowledge economy and high-end services have a distinct role in the economic system and in transformation of the social state in the context of globalisation. This project will submit the current situation to an interdisciplinary analysis and provide a suggestion of a future scaffolding that will be possible both in legal and in economic terms, at the same time grant the end-user benefits of personalized medicine, biotechnology and cutting-edge research. New biotechnologies are the source of challenges on different levels. In the widest perspective, they promise to bring about the clash of globalization, Europeanization and transition. Focusing on the EU in particular, they may bring about changes in the open methods of coordination and shake up the European social model. The national social state is also likely to be affected.The project will therefore gather biotech, legal and economic experts to deliver a platform for identification of challenges posed by development of new technologies in the field of medicine to the society in general; the way the new technological advances may affect the development of a constitutional democracy and the way the mechanisms of this democracy may affect the new technologies.Important social, regulatory, legal, ethical and moral issues will be analysed within this Project. A central issue to be covered is therefore finding adequate ways for a proper communication between scientists, health care providers, patients and health insurance providers, who all need to understand what they are dealing with in order to define their roles and responsibilities. The objectives of the project address scientific, policy, infrastructure and education issues.  Specific recommendations include: road mapping (defining research agendas); funding (define future Joint programming projects); education; synergies (creation of inter-disciplinary networks); knowledge transfer and communication; impact (through wide dissemination in journals, books, etc.).]]></summary_en></project><project>
<id>2003</id><title_hr><![CDATA[Epigenetičke promjene karcinoma pločastih stanica glave i vrata]]></title_hr><title_en><![CDATA[Epigenetic changes in head and neck squamous cell carcinoma]]></title_en><user_id>572</user_id><user_firstLast_name>Magdalena Grce </user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-4758</code><acronim><![CDATA[EpiC-HNSCC]]></acronim><duration>18.06.2014 - 17.10.2018</duration><status>Završio</status><financ_value>99.542,11 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>3294, 898, 4023, 5477, 2696, 2507, 2728, 3949, 17822, </team_members_id><team_members_names><![CDATA[Nina  Milutin Gašperov, Ivan Sabol, Marinka  Mravak-Stipetić, Drago Prgomet, Zoran Rakušić, Antonia Jakovčević, Spomenka Manojlović, Emil Dediol, Ksenija Božinović, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[methylation, microRNA, HPV, head and neck cancer, biomarker]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Head and neck squamous cell carcinoma (HNSCC) is the sixth most common malignancy worldwide. Despite aggressive treatment of HNSCC patients, which entails surgery, chemo- and radio-therapy, the five-year survival is only 40-50%. Tobacco, alcohol, microbial factors (high-risk human papillomaviruses, hrHPVs), systemic factors (immunosuppression, micronutrient deficiency) and UV-radiation are common risk factors for development of HNSCC. HNSCC patients with HPV infection were found to have better prognosis and treatment response. Besides the HPV status, no adequate biomarkers have been found so far to predict the poor/good clinical outcome nor is the mechanism of how HPV modulates therapy response fully understood. Epigenetic changes such as DNA methylation of specific gene promoters and posttranscriptional modification of gene expression by specific microRNA (miRNA) seems to be promising biomarkers of disease occurrence and progression. Therefore, the primary objective of this project is to identify novel specific epigenetic biomarkers to predict early-stage of HNSCC, notably oral and oropharyngeal cancer, patients at greater risk for developing invasive cancer, and finally understand treatment response in patient with HPV-associated cancers. State-of-the-art technologies, wide-genome microarray assay and types-specific validation of DNA methylation and miRNA profiles (methylome and mirome, respectively) will be used on subsets of healthy tissue, HPV-related and HPV-unrelated precancerous oral lesions, oral and oropharyngeal cancer, and metastasis. The integration of all findings should yield ideal epigenetic biomarkers. This project is a comprehensive interdisciplinary research, which includes basic and clinical research, and will enable the improvement of existing knowledge, development of new technological approaches in diagnostics and prognostics, and possible new treatment approach for oral and oropharyngeal cancer.]]></summary_en></project><project>
<id>2017</id><title_hr><![CDATA[Identifikacija i funkcionalna karakterizacija (eko)toksikološki važnih polispecifičnih membranskih transportnih proteina u zebrici (Danio rerio)]]></title_hr><title_en><![CDATA[Identification and functional characterization of (eco)toxicologically relevant polyspecific membrane transport proteins in zebrafish (Danio rerio) ]]></title_en><user_id>986</user_id><user_firstLast_name>Tvrtko Smital</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-4806</code><acronim><![CDATA[TRANS-ZEBRATOX]]></acronim><duration>01.10.2014 - 30.04.2018</duration><status>Završio</status><financ_value>108.979,67 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>4504, 4272, 1050, 1063, 3923, 17738, </team_members_id><team_members_names><![CDATA[Roko Zaja, Marta Popović, Ivan Mihaljević, Petra Marić, Jovica Lončar, Jelena Dragojević, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[polyspecific uptake and efflux transporters, zebrafish, identification, functional characterization, knockout studies, (eco)toxicological relevance ]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[A coordinated system of transport proteins, channels, receptors and enzymes act as cellular gatekeepers to foreign molecules, critically determining the so-called ADME-Tox (absorption, distribution, metabolism, excretion – toxicity) properties of a molecule. The polyspecific uptake and efflux transmembrane proteins are essential components of this complex cellular defense and detoxification/xenobiotic processing machinery in mammals, highly important and widely recognized in the context of pharmacology and human toxicology. However, they are scarcely investigated in non-mammalian species, and not adequately addressed in the field of environmental toxicology. Consequently, the major goal of the proposed project is identification and detailed functional characterization of new, potentially (eco)toxicologically relevant uptake and efflux transport proteins not addressed so far in the context of environmental toxicology, or in non-mammalian species in general. Our research will be focused on selected polyspecific uptake transport proteins from the SLC21 and SLC22 (Solute Carriers) proteins families, the efflux transporters from the MATE (multidrug and toxic compound extrusion proteins) family, and finally the RLIP76 as the most recently discovered stress-responsive, multi-functional membrane protein. We will use zebrafish (Danio rerio) as a highly relevant vertebrate research model, and our methodological approach will be based on several subsequent research phases: phylogenetic and gene expression analyses; transfection studies in appropriate heterologous expression system(s); transport-activity assays; analyses of the transport mechanism and structural properties; high-throughput-screening identification of chemical interactors of selected transporters among environmental contaminants; and finally in vivo evaluation of the (eco)toxicological relevance of selected transporters using the zebrafish functional genomics tools.]]></summary_en></project><project>
<id>2026</id><title_hr><![CDATA[Mreže javnog komuniciranja u Hrvatskoj: medijatizacija javne sfere i izazovi novih medija]]></title_hr><title_en><![CDATA[Networks of public communication in Croatia: mediatisation of the public sphere and the challenges of new media]]></title_en><user_id>3039</user_id><user_firstLast_name>Nada Švob-Đokić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-4014</code><acronim><![CDATA[NETCOMM]]></acronim><duration>01.09.2014 - 31.03.2016</duration><status>Prekinut</status><financ_value>14.424,96 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Sociologija, </scie_field_hr><scie_field_en>Sociology, </scie_field_en><institution_hr><![CDATA[Institut za razvoj i međunarodne odnose]]></institution_hr><institution_en><![CDATA[Institute for Development and International Relations]]></institution_en><team_members_id>1329, 190, 4507, </team_members_id><team_members_names><![CDATA[Paško Bilić, Ivan Balabanić, Nina Obuljen Koržinek, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Networks, public communication, public sphere, mediatisation, new media, Croatia]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The media and society are tightly intertwined in a close and dynamic relationship. Shaped by societies, the media also shape societies. This relationship engenders social change that is at the core of the current mediatisation process and theory debates (Schulz, 2004; Krotz, 2007; Hjarvard, 2008; Hepp, 2011). Networked communication technologies reshape the equilibrium of the media/society relationship and extend the mediatisation process to new directions. The process is not a straightforward technological impact, but a complex accommodation process. In this research we study how the public sphere (Habermas, 1991) has been reshaped through networked communication (Cardoso 2008). We focus on four aspects of mediatisation: extension, substitution, amalgamation and accommodation (Schulz, 2004) to study organizational changes in the process of media production; and media use and practices among internet users. The main objective is to understand processes of media production, consumption and their interrelations, with regard to public communication through new, online and networked media. Specific goals include contributions to development of the mediatisation theory; establishment of a classification of online media in Croatia; development of mixed methods research designs and providing impetus to related public policies. We employ a sequential, explorative research strategy (Creswell, 2009). In the first stage, we conduct multiple, qualitative case studies of the processes of organizational change in different online media. In the second, intermediary stage we construct survey questionnaires based on previous qualitative work. In the third stage, we use a survey on a national representative sample and provide further analytical conclusions derived from the research. The potential users of our research results include: scientific research communities, media industry, media organizations, policy decision-makers, regulatory institutions, and various NGOs.]]></summary_en></project><project>
<id>2027</id><title_hr><![CDATA[Upravljanje povjerenjem i koordinacija interakcija u pametnim mrežama ljudi, strojeva i organizacija]]></title_hr><title_en><![CDATA[Managing Trust and Coordinating Interactions in Smart Networks of People, Machines and Organizations]]></title_en><user_id>2602</user_id><user_firstLast_name>Vedran Podobnik</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2013-11</proposal_call><code>UIP-2013-11-8813</code><acronim><![CDATA[SmartPMONetworks]]></acronim><duration>01.07.2014 - 30.06.2017</duration><status>Prekinut</status><financ_value>109.262,06 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>2989, 2612, 5883, 2717, 6404, 6415, 4894, 6453, 20486, 20516, </team_members_id><team_members_names><![CDATA[Iva Bojić, Gordan Ježić, Darko Štriga, Ignac Lovrek, Luka Vrdoljak, Jurica Babić, Marina Bagić Babac, Vanja Smailovic, Goran Jelen, Ivana Rašan, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[social networks, machine-to-machine communication, networked organizations, networked society, trust, coordination, context-awareness, big data]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[We live in a networked society where everything is connected. By 2020 there will be 8 billion people and 50 billion machines in the world and almost all of them will be connected through some kind of network. Furthermore, people and machines that share a certain collective goal will be grouped into some kind of organization, which again will be connected with other organizations and/or people/machines. In order to maintain sustainability of the networked society we need a framework and algorithms which will enable us to i) manage trust; and ii) coordinate interactions in such a complex eco-system consisting of thousands, millions or even billions of interconnected entities. Both the framework and algorithms should be scalable and robust (from the perspective of a network size and heterogeneity), support real-time dynamics (from the perspective of network interactions) as well as be applicable and analyzable at different levels of granularity (at a micro, mezzo and macro network levels). A possible solution for the framework is the “Smart Network”, where people/machines/organizations are represented as nodes which are described by profiles and build a network of connections. The “smartness” of “Smart Networks” stems from profiling nodes and realizing connections using automated computational methods, what is enabled by latest enhancements in information systems and state-of-the-art solutions in communication technologies. The “Smart Network” framework enables design of scalable, robust and real-time algorithms for managing trust and coordinating interactions because it can be i) formally operationalized as a graph where edges represent nodes and vertices represent connections; ii) functionally modeled as a multi-agent system where agents embody edges and relationships embody vertices; and iii) analyzed through complexity theory where sustainable solutions emerge as a result of a bottom-up modeling principle.]]></summary_en></project><project>
<id>2031</id><title_hr><![CDATA[Primjena nanomaterijala u izradi potenciometrijskih tenzidnih senzora za primjenu u industriji i zaštiti okoliša]]></title_hr><title_en><![CDATA[The use of nanomaterials in the construction of potentiometric surfactant sensors for industrial and environmental applications]]></title_en><user_id>4824</user_id><user_firstLast_name>Milan Sak-Bosnar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-9060</code><acronim><![CDATA[NANOSENS]]></acronim><duration>01.07.2014 - 30.06.2017</duration><status>Završio</status><financ_value>72.433,72 eur</financ_value><scie_area_hr>Prirodne znanosti, Tehničke znanosti, </scie_area_hr><scie_area_en>Natural sciences, Technological sciences, </scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Odjel za kemiju]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Department of Chemistry]]></institution_en><team_members_id>3613, 4188, 3597, 4397, 4128, 3616, 4919, 3531, 6981, 6620, 7300, 17818, </team_members_id><team_members_names><![CDATA[Mirela Samardžić, Nikola Sakač, Olivera Galović, Marija Jozanović, Sanja Petrušić, Martina Medvidović-Kosanović, Martina Šrajer Gajdošik, Tomislav Balić, Sanja Martinez, Lidija Valek Žulj, Dubravka Madunić-Čačić, MATEJA HAJDUKOVIĆ, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[surfactant, analysis, sensor, potentiometry, nanomaterial, environment, industry]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The project comprises development and construction of a nanomaterials-based potentiometric surfactant sensor, that will be used for measurement of ionic surfactants concentration in surfactant raw materials, consumer products, pharmaceutical and cosmetic products, environmental materials etc. The new sensor should eliminate the drawbacks of the standard time-consuming extraction-spectrophotometric procedures and classical polymer liquid membrane based sensors. It can be used as an end-point detector by potentiometric titration of ionic surfactants or by their direct potentiometric determination.The new sensor can be also used as a specific detector in microfluidic techniques such as Flow Injection Analysis (FIA), Sequential Injection Analysis (SIA), as well as in the separation techniques (HPLC), substituting in this way more expensive, larger nonspecific detectors such as optical and conductivity detectors etc.]]></summary_en></project><project>
<id>2032</id><title_hr><![CDATA[Tvar i međudjelovanja na ubrzivačima  i u svemiru]]></title_hr><title_en><![CDATA[Matter and Interactions at Accelerators and in Universe]]></title_en><user_id>335</user_id><user_firstLast_name>Krešimir Kumerički</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-8799</code><acronim><![CDATA[MIAU]]></acronim><duration>01.06.2014 - 30.09.2018</duration><status>Završio</status><financ_value>105.236,84 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>5932, 5292, 3358, 3140, 3059, 3183, 5958, 3243, 3129, 3602, 17794, </team_members_id><team_members_names><![CDATA[Sanjin Benić, Ivan Dadić, Davor Horvatić, Amon Ilakovac, Dalibor Kekez, Dubravko  Klabučar, Dieter Mueller, Ivica Picek, Luka Popov, Branimir Radovčić, Petar Čuljak, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[quantum chromodynamics, hadrons, quarks and gluons, quark matter, leptons, neutrino mass, new particles at LHC, dark matter]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[     Hadrons, such as proton or pion, are particles composed ofquarks and gluons which interact through fundamental strongforce. Objective of MIAU project is to contribute to ourunderstanding of this strong force as described by thetheory of quantum chromodynamics (QCD). Additionally, we aimto study physical processes happening at hadronaccelerators, including electroweak production ofas-yet-unseen particles at the large hadron collider (LHC).Thereby, we will investigate models of new physics in whichsuch new particles are introduced in attempts to explainneutrino masses and abundance of dark matter in theuniverse.     To achieve these objectives we will study specific hadronicprocesses, both in the high-energy regime where strong forceis weak enough for perturbative approach, as well as inregimes where non-perturbative features of QCD, such asconfinement and chiral symmetry breaking come to the fore.Our focus will be on processes measured by the range ofexperimental collaborations which will facilitate closecontact with reality and immediate testing of our resultsand ideas.     As outcome, we expect to be able to significantly improvethe knowledge of the quark-gluon structure of the proton, asencoded by the so-called generalized parton distributions,to improve the description of various meson properties invacuum and at finite densities and temperatures, toelucidate QCD phase diagram in model frameworks, and to setbounds to the parameter space of several models of newphysics.]]></summary_en></project><project>
<id>2050</id><title_hr><![CDATA[Utvrđivanje sastava crijevne mikrobiote, upalnih markera, prehrambenog i endokrinog statusa u pacijenata s upalnom bolesti crijeva]]></title_hr><title_en><![CDATA[Assessment of Microbiota, Inflammatory Markers, Nutritional and Endocrinological Status in IBD Patients]]></title_en><user_id>5552</user_id><user_firstLast_name>Donatella Verbanac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-5467</code><acronim><![CDATA[MINUTE for IBD]]></acronim><duration>01.09.2014 - 31.08.2018</duration><status>Završio</status><financ_value>132.510,45 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>4214, 5577, 4152, 967, 965, 1278, 6237, 1398, 6406, 5897, 5241, 4012, 1369, 4183, 6297, 4249, 5562, 6316, 13628, 3288, 12582, 13684, </team_members_id><team_members_names><![CDATA[Željko Krznarić, Silvija Čuković-Čavka, Marko  Brinar, Mihaela Perić, Hana Čipčić Paljetak, Mario Matijašić, Vera Kufner, Darija  Vranešić Bender, Nikša Turk, Marija Crnčević Urek, Mirjana Kalauz, Karmen Brajša, Gabrijela Ergović, Anja Barešić, Ivana Kraljević, Dina Ljubas Kelečić, Dora Grgić, Ana Kunovic, Marina Panek, Dunja Rogić, Tomislav Meštrović, Marko Banic, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[IBD, microbiota, blood biomarker, tissue, translational research, clinical research]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Inflammatory bowel disease (IBD) is a chronic gastrointestinal disorder with increase in incidence that severely deteriorates patients’ quality of life. The onset of the disease is mainly associated with the immune status, gut microbiota and food intake. The current scientific knowledge of specific triggers and diagnostic markers is limited; therefore, new data on gut microbiota, inflammatory, endocrine and nutritional status are required to better understand the IBD pathophysiology.It this study we will thoroughly explore host-gut microbiota interactions in order to define novel strategies for management of IBD.We will collect intestine biopsies, stool and blood samples from 40 newly diagnosed IBD patients and 20 non-IBD control individuals, as well as record their nutritional status. Since majority of the gut microorganisms are not culturable, we will use the in house available next-generation sequencing to characterize the composition of the microbiota in collected samples. Moreover, specific blood biomarkers, including cytokines, growth factors and hormones, will be determined using novel and highly sensitive proximity extension assays, recently developed in our laboratories. Collectively, these results will support better stratification of patients and initiate an appropriate therapy.]]></summary_en></project><project>
<id>2054</id><title_hr><![CDATA[Epistemološki modeli hrvatske književne historiografije (1913-1980)]]></title_hr><title_en><![CDATA[Epistemological Models of Croatian Literary Historiography (1913-1980)]]></title_en><user_id>5895</user_id><user_firstLast_name>Leo Rafolt</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2013-11</proposal_call><code>UIP-2013-11-2242</code><acronim><![CDATA[EPISTEMLITHIST]]></acronim><duration>02.06.2014 - 01.06.2017</duration><status>Prekinut</status><financ_value>50.660,30 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filologija, </scie_field_hr><scie_field_en>Philology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>5066, 2947, 6647, </team_members_id><team_members_names><![CDATA[Dolores Grmača, Milovan Tatarin, Julijana Matanović, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[epistemology, literary history, theory of literary historiography, Marxist literary history, philological approach, textology, stylistic criticism]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The project covers one of the most interesting periods of development of the Croatian literary studies. It analyzes it regarding the systems  of knowledge or epistemological matrixes and predominant hermeneutic paradigms in the context of European and Anglo-American literary historiography. Research period is delimited by the year 1913, when one of the first overall synthesis of the Croatian literature was published (B. Vodnik, Povijest hrvatske književnosti), and the year 1980, when the first anthropologically implemented theories of literature occur in our academic context. These two extremes, in the periodical sense, are thus interconnected, primarily because of the hermeneutic concepts announced by the early Croatian literary historians, s.a. Vodnik, Prohaska, Hergešić. The goals of this continuous research activity is to analyze: (1) dominant systems of knowledge significant for the development of Croatian literary historiography, s.a. positivism, folk-psychology, psychoanalysis in its Freudian sense, aestheticism, first phase of the responsive theories, applied sociology of literature, early Marxism, formalist, structuralist, stylistic criticism, early poststructuralism, anthropological tendencies; (2) dominant figures of Croatian literary historiography and their methods, derived from their published works, starting from B. Vodnik, D. Prohaska, T. Matić etc., all the way to I. Slamnig, Ž. Jeličić, M. Vaupotić, I. Frangeš, S. Lasić; (3) dominant figures of our literary historiography and their unpublished oeuvres (s.a. Vodnik, Kombol, Prohaska, Matković), which will be published in a critical form; (4) comparative context of this literary historiography, regarding dominant circles in the 20th century (s.a. Czech and Polish circle, Ljubljana school of literary history, German and Italian academic milieu and its influence on the Zagreb stylistics, French structuralism in Croatian milieu).]]></summary_en></project><project>
<id>2058</id><title_hr><![CDATA[RIMSKODOBNA PREOBRAZBA I UPORABA PRAPOVIJESNIH GRADINA U ISTRI - ANALIZA I STUDIJA SLUČAJA]]></title_hr><title_en><![CDATA[ROMAN AGE TRANSFORMATION AND REUSE OF PREHISTORIC HILLFORTS IN ISTRIA – ANALYSIS AND CASE STUDY]]></title_en><user_id>3231</user_id><user_firstLast_name>Klara Buršić-Matijašić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-2370</code><acronim><![CDATA[RAT-ROPH]]></acronim><duration>01.07.2014 - 30.06.2018</duration><status>Završio</status><financ_value>62.081,09 eur</financ_value><scie_area_hr>Humanističke znanosti, Prirodne znanosti, </scie_area_hr><scie_area_en>Humanities, Natural sciences, </scie_area_en><scie_field_hr>Arheologija, </scie_field_hr><scie_field_en>Archeology, </scie_field_en><institution_hr><![CDATA[Sveučilište Jurja Dobrile u Puli]]></institution_hr><institution_en><![CDATA[Juraj Dobrila University of Pula]]></institution_en><team_members_id>5386, 4408, 5306, 5525, 5481, 3440, 823, </team_members_id><team_members_names><![CDATA[Giovanni Boschian, Davor Bulić, Maša Sakara Sučević, Jana Škrgulja, Sandra Šoštarić, Katarina Gerometta, Robert Matijašić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Istria, prehistoric hillfort, ancient landscape, roman villa, geoarchaeology, GIS, spatial analysis]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Prehistoric hillforts are characterised by their position on heights with excellent strategic and defensive traits. An impressive number of settlements of this type can be found in Istria, representing an interesting scientific and important cultural phenomenon. Most of the hillforts were established during the Bronze Age, and due to population increase and social stratification they were transformed from simple settlements into pre- and proto-urban centres. While the ethnic identity of the Bronze Age population is still unknown, the ethnically uniform population of the Histri inhabited these settlements during the Iron Age. After the Roman conquest of Istria most hillforts were abandoned; some of them remained in use, but under different circumstances and conditions which led to their substantial modification. Despite the large number of these sites (240 confirmed, 200 hypothetical), few of them were systematically excavated. Previous research was limited to intra-site interpretation and to targeted field survey. The main goals of this project are to identify anthropogenic landscape change at the time of the conversion of site function, and to obtain new insights on the spatial organisation of settlements and their relationships with the surrounding environment. Landscape studies, geoarchaeology, topography and archaeology will be integrated under interdisciplinary GIS environment, providing a new holistic interpretation of past landscape dynamics. This research will fill the gap in the understanding of human-landscape interaction and of anthropic transformation of land from Late Prehistory to Roman times. A case study on human impact on landscape will be conducted in the micro-region of Poreč, and will be explained within its broader regional context. The project will also provide training for young researchers involved in PhD programmes, giving them the chance to develop interdisciplinary skills and encouraging them to become successful independent scientists.]]></summary_en></project><project>
<id>2059</id><title_hr><![CDATA[GRAĐANSKOPRAVNA ZAŠTITA GRAĐANA U FINANCIJSKOJ KRIZI]]></title_hr><title_en><![CDATA[CIVIL LAW PROTECTION OF CITIZENS IN THE FINANCIAL CRISIS]]></title_en><user_id>5005</user_id><user_firstLast_name>Tatjana Josipović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-5269</code><acronim><![CDATA[CitProtect]]></acronim><duration>01.02.2015 - 31.01.2018</duration><status>Završio</status><financ_value>42.421,84 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Pravo, </scie_field_hr><scie_field_en>Law, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Pravni fakultet u Zagrebu]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Law]]></institution_en><team_members_id>6925, 6935, 5532, 7065, 1042, 1434, 4150, 3842, 235, 3982, 5924, 21146, </team_members_id><team_members_names><![CDATA[Ksenija Grubišić, Siniša Petrović, Igor Gliha, Hano Ernst, Ivana Kanceljak, Ana Keglević, Josip Tica, Saša Nikšić, Iva Kuštrak Managić, Romana Matanovac Vučković, Marko Baretić, Jan Torjanac, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[civil law, protection of citizens, financial crisis, responsible lending, information duty, debt management, debt collection]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The main, overall aim of this research is twofold. First, the team will analyse the question of the influence of the existing civil law system to the aggravation of the financial difficulties of citizens. Second, the team will analyse the question of potentials of the civil law system for remedying these difficulties and for preventing them in the future. The team shall focus on five objectives: 1. researching the legal model of pre-contractual obligations of traders to inform citizens of their contractual rights and obligations, 2. researching the legal model of responsible lending, 3. researching the model for the protection of citizens in case of a deterioration of the financial situation after agreeing to and/or defaulting on a monetary obligation, 4.researching alternative models of voluntary performance of monetary obligations, and 5. researching the models of civil law protection of citizens in debt collection.The aim of the project is to find optimum measures, both of regulatory and non-regulatory nature, which are necessary to be implemented in order to improve unfortunate financial position of citizens.The research is projected to be undertaken in four consecutive stages or “work packages” (WP’s) in total duration of three years. WP 1 consists of the analysis of the legislation, theory and case law in the field of civil law which has an impact of the current financial crisis of citizens. WP 2 consists of empirical survey. WP 3 consists of the development of recommendations of measures of regulatory and non-regulatory nature which should be implemented in order to improve the existing legal, economic and social environment to the benefit of citizens. WP 4 consists of dissemination of the results of the research.]]></summary_en></project><project>
<id>2063</id><title_hr><![CDATA[Nestali jezerski krajobrazi istočnog dijela Jadranskog mora]]></title_hr><title_en><![CDATA[Lost Lake Landscapes of the Eastern Adriatic Shelf]]></title_en><user_id>162</user_id><user_firstLast_name>Slobodan Miko</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-9419</code><acronim><![CDATA[ LoLADRIA]]></acronim><duration>01.07.2014 - 30.06.2018</duration><status>Završio</status><financ_value>104.581,77 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Geologija, </scie_field_hr><scie_field_en>Geology, </scie_field_en><institution_hr><![CDATA[Hrvatski geološki institut]]></institution_hr><institution_en><![CDATA[Croatian Geological Survey]]></institution_en><team_members_id>4970, 3521, 5598, 5844, 5052, 6839, 5740, 5741, 6095, 6065, 3511, 7598, 7588, 7597, 7552, 17774, </team_members_id><team_members_names><![CDATA[Ivan Razum, Valentina Hajek-Tadesse, Dragan Bukovec, Tamara Marković, Nikolina Ilijanić, Ozren Hasan, Vlasta Premec Fućek, Morana Hernitz Kučenjak, Saša Mesić, Martina Šparica Miko, Koraljka Bakrač, George Papatheodorou, Maria Geraga, George Ferentinos, DIMITRIOS CHRISTODOULOU, Dea Brunović, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Paleolimnology, Paleoclimate, Last Glacial Maximum, Holocene, Pleistocene, Mesolithic, Sea Level Rise, Proxies, Human Migration, Adriatic Shelf, Karst]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The LoLADRIA project represents a multidisciplinary, effort to recover, for the first time, long paleoenvironmental, and paleoclimate records from existing coastal karst lakes and submerged karstic lakes of the eastern Adriatic shelf in Croatia. The project will attempt to reconstruct the specific karst lake landscapes and their surroundings in view of environmental and climate change and human migration from the Last Glacial Maximum (LGM) through the Holocene. LoLADRIA will provide long, high resolution, paleohydrological reconstructions from a region extremely sensitive to changes in effective moisture and atmospheric dynamics. The multiproxy-based reconstructed curves will provide new data to identify and date the main climate events, and to characterize the climate variability at century and millennium scale since the LGM. Pollen and ostracods offer the possibility to develop transfer functions in order to reconstruct quantitative changes in regional climate and hydrological conditions of the lakes. LoLADRIA will offer an environmental context which enabled the human entrance to Europe along the eastern Adriatic shelf since this pathway is still widely unknown and the detailed framework of climatic and environmental conditions still requires extensive research. In combination with landscape reconstruction based on high resolution geophysical methods will allow the insight to the preserved changes in the landscapes at selected sites along the Eastern Adriatic and their habitability related to the Mesolithic cultures that were present there. Submarine  prehistoric  sites  in  the  Mediterranean  show  that  the  continental  shelf was  occupied  by  humans  to  a  depth  of  at  least  -40m, and the lost (submarine) lakes and surrounding submerged landscapes of the eastern Adriatic have a potential for site discovery.]]></summary_en></project><project>
<id>2065</id><title_hr><![CDATA[Hrvatska srednjovjekovna baština u europskom kontekstu: mobilnost umjetnika i transfer oblika, funkcija i ideja]]></title_hr><title_en><![CDATA[Croatian medieval heritage in European context: mobility of artists and transfer of forms, functions and ideas]]></title_en><user_id>5939</user_id><user_firstLast_name>Miljenko Jurković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-6095</code><acronim><![CDATA[CROMART]]></acronim><duration>15.06.2014 - 14.06.2018</duration><status>Završio</status><financ_value>79.633,69 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Povijest umjetnosti, </scie_field_hr><scie_field_en>Art history, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>839, 1244, 6253, 4714, 5985, 6944, 5797, 2561, 6375, 6039, 6260, 6090, 6382, 6390, 5523, 6041, 7112, 7157, 6071, 6354, 6026, 6360, 7191, 7320, 7192, 6694, 7362, 6098, </team_members_id><team_members_names><![CDATA[Marijan Bradanović, Ivan Matejčić, Krešimir Karlo, Maurizio Levak, Sunčica Mustač, Ranko Starac, Predrag Marković, Josipa Lulić, Xavier Barral i Altet, Gian Pietro Brogiolo, Jean-Pierre  Caillet, Chevalier Pascale, Morana Čaušević-Bully, Sebastien Bully, Vincenza Lucherini, Jana Maříková-Kubková, Mihailo Milinković, Alejandra Chavarria, stefano riccioni, Angela  Borzacconi, Milagros  Guardia , Carles Mancho, Géraldine Mallet, Terrier Jean, Maja Zeman, Sapin Christian, Joan Molina Figueras, Enrico Cirelli, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Late antiquity, middle ages, architecture, sculpture, painting, forms, functions, artistic transfers, historical landscape]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The project puts Croatia in the focus of European research of the middle ages. The international team will implement already elaborated methodologies combined with new technologies (geo-radar, remote sensing) on the medieval artistic heritage of Croatia as to track and map the changes that occurred in monumental landscape in the time span from late antiquity to the late middle ages. Croatia was a border zone between super-powers: eastern and western Roman Empire; Byzantium and respectively Lombard, Carolingian, Ottonian rule; from the 11th c. on, the powers of the West change: the Papacy and Venice, then Hungary. The ecclesiastical and social elites as protagonists of political and diplomatic activities have always strengthened their power by investing and sponsoring architecture and works of art. Those investors often commissioned works of art in their respective countries or summoned architects, sculptors and painters.The main goal of this project is to track down those artists who came from abroad as well as those going out from Croatia and to analyse the origins of the forms and functions of architecture built from late antiquity to the late middle ages. The understanding of the transformation of the Roman world in late antiquity and the early middle Ages, the need to track those changes in a longer time span, even within the growth of the medieval feudal society and to explain the role of the elites becomes fundamental. To answer those questions large field surveys will be carried on as well as the research of elites as investors and carriers of ideas, forms and functions of ecclesiastical architecture. The team is divided in working groups covering different historical regions of Croatia, submitted to very different influences during the middle ages, as well as covering different chronological sequences. By means of thorough field survey, creating catalogue data of architecture, sculpture and painting, through comparative analysis the goal will be achieved. ]]></summary_en></project><project>
<id>2066</id><title_hr><![CDATA[Razvoj naprednih energetski učinkovitih struktura upravljanja generatorom sa stalnim magnetima bez mjernog člana ]]></title_hr><title_en><![CDATA[Development of Advanced Sensorless Control of Permanent Magnet Generator for Improving Energy Efficiency]]></title_en><user_id>5949</user_id><user_firstLast_name>Damir Sumina</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2013-11</proposal_call><code>UIP-2013-11-7601</code><acronim><![CDATA[PMGEFC]]></acronim><duration>01.09.2014 - 30.04.2018</duration><status>Završio</status><financ_value>80.164,58 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>6380, 6695, 2674, 3279, 17782, 19026, 6481, 22554, </team_members_id><team_members_names><![CDATA[Igor Erceg, Martina Kutija, Ivan Mrčela, Tanja Poljugan, Tin Bariša, Igor Sirotić, Šandor Ileš, Luka Pravica, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[permanent magnet generator,  wind power generation, back-to-back converter, energy efficiency,  sensorless control,]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Renewable energy sources have been attracting great attention due to the cost increase, limited reserves and advanced environmental impact on fossil fuels. In the meantime, technology advancements, cost reduction and governmental incentives have made some renewable energy sources more competitive in the market. Among them, wind energy is the one of the fastest growing renewable energy sources. The conversion of the wind energy into electric energy is of a multidisciplinary nature, involving aerodynamics, mechanical systems, electric machines, power electronics, control theory, and power systems.The main goal of this project is to establish new research group which will improve the quality, performance and competitiveness of industrial sector in the field of wind power generation. The research group has already participated in the project for the development of advanced control structures for induction generator connected via back-to-back-converter to the grid in wind turbine application. As a step forward in innovation, research and development the research focus is set on permanent magnet synchronous generator (PMG) parameter identification, estimation of PMG rotor position using high frequency signal injection and speed estimation. Also, focus is on energy efficient based control method such as model predictive control of PMG. Advanced sensorless control algorithms for PMG will be developed and experimentally verified on the industrial laboratory model. Basic infrastructure for implementation and verification of developed algorithms exists in the Laboratory and for testing of advanced control structures on PMG laboratory model needs to be further upgraded. The final result will be the capability of research group for future cooperation with industrial partners for development of wind power generator systems and other generation systems.]]></summary_en></project><project>
<id>2068</id><title_hr><![CDATA[Nespecifična imunost na hantaviruse]]></title_hr><title_en><![CDATA[Innate immunity to hantaviruses]]></title_en><user_id>5967</user_id><user_firstLast_name>Alemka Markotić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-4393</code><acronim><![CDATA[HANTA-INNATE]]></acronim><duration>01.07.2014 - 30.11.2018</duration><status>Završio</status><financ_value>132.059,19 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Ništa od navedenog]]></institution_hr><institution_en><![CDATA[Nothing from this list]]></institution_en><team_members_id>6924, 5654, 5653, 5650, 4412, 7152, 4999, 7127, 5641, </team_members_id><team_members_names><![CDATA[Ofer Mandelboim, Lidija Cvetko Krajinović, Ivan-Christian Kurolt, Ante Tadin, OKTAVIJA ĐAKOVIĆ RODE, Dragan Ledina, ĐURĐICA CEKINOVIĆ, Ljiljana Žmak, Petra Svoboda, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[hantavirses, Puumala, Dobrava, reoinfection, acute infection, monovytes, macrophages, NK cells, innate immunity, hemorrhagic fever with renal syndrome]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Hantaviruses (HTV), family Bunyaviridae, are emerging, enveloped RNA viruses, which cause hemorrhagic fever with renal syndrome (HFRS) in Croatia and in the rest of Europe, where two main HTV cause HFRS: Puumala (PUUV) and Dobrava (DOBV). A broad spectrum of HFRS clinical conditions has been recognized, ranging from inapparent or mild to a fulminant hemorrhagic process with severe renal failure and death. The strong proinflammatory response during acute infection in humans is probably responsible for viral clearance but also for potentially fatal proinflammatory-mediated disease. Innate immunity is the first line of defense to various pathogens which may substantially determine the further development and outcome of disease. There is strong lack of knowledge on innate immune response to HTV in acute phase of disease and no evidence on immune response to reinfection with HTV at all. Overall objective of this project is to identify some key elements of innate immune response in acute HFRS infection and in experimentally simulated HTV reinfection at the level of  monocytes/macrophages, NK cells, their crosstalk, “memory” and potential mediation by microRNAs (miRNAs). For that purpose, ex vivo experiments on peripheral blood mononuclear cells, monocytes/macrophages and NK cells will be performed in patients with acute HFRS and patients previously encountered HFRS. Primary monocytes/macrophages and NK cells will be additionally infected with HTV and co-cultivated. In order to asses potential miRNAs role, some inhibition experiments will be performed. Computational analysis will follow all experimental process in order to generate new data, pursue study in right direction and indicate important signaling pathways for the future research. Such concept may represent the next step in the design of future vaccines for HTV.]]></summary_en></project><project>
<id>2070</id><title_hr><![CDATA[Stvaranje grada: prostor, kultura i identitet]]></title_hr><title_en><![CDATA[CIty-making: space, culture and identity]]></title_en><user_id>1045</user_id><user_firstLast_name>Jasna Čapo Žmegač</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-2350</code><acronim><![CDATA[CITID]]></acronim><duration>01.10.2014 - 30.09.2018</duration><status>Završio</status><financ_value>77.642,84 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Etnologija i antropologija, </scie_field_hr><scie_field_en>Ethnology and anthropology, </scie_field_en><institution_hr><![CDATA[Institut za etnologiju i folkloristiku]]></institution_hr><institution_en><![CDATA[Institute of Ethnology and Folklore Research in Zagreb]]></institution_en><team_members_id>311, 4785, 5400, 4789, 4712, 5288, </team_members_id><team_members_names><![CDATA[Valentina Gulin Zrnić, Nevena Škrbić Alempijević, Laura Šakaja, Tihana Rubić, Petra Kelemen, Sanja Đurin, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[urban anthropology, city, everyday life and culture, politics of space, politics of difference, urban identities, anthropology of migration ]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The project has emerged from theoretical insights in urban anthropology, anthropology of space and place, urban migration studies, cultural geography, post-socialist studies and post-colonial theory. It proposes a complex research outline based dominantly on qualitative methodology, aiming at untangling and comprehending multiple, multilayered and interdependent (f)actors and processes that influence contemporary transformations in the Croatian capital, Zagreb. The concept of city-making in this research refers to a comprehensive construction and articulation of urban life along two axes—space and diversity. Both constitute nodes at which global political, economic and cultural flows meet and collide with local histories, way of life, imaginaries, interests and developments, bringing about the restructuring of the city and its identity as well as identities of city inhabitants. This ethnological and cultural anthropological project emphasises agency of city dwellers in these transformations and investigates how they negotiate and re-create the given social, cultural, and spatial landscape (cityscape) investing it with meaning and humanising it. The project will have an important bearing on the city&#39;s politics and policies, with the goal of achieving more sustainable and inclusive functioning of the city while, at the same time, it will advance the state of the art of urban studies. In addition, it will ensure the transfer of knowledge via university courses and public presentations aimed at raising the awareness about various urban issues (planning, environment, representation, cultural production, diversity, marginality etc.).]]></summary_en></project><project>
<id>2072</id><title_hr><![CDATA[Istraživanje patoloških procesa u ljudskom ishemičnom miokardu; bazični znanstveni pristup za razumijevanje najčešće bolesti današnjice]]></title_hr><title_en><![CDATA[Investigating Pathological Processes in Ischemic Human Myocardium; Basic Science Tools for Major Health Problem]]></title_en><user_id>187</user_id><user_firstLast_name>Darija Baković Kramarić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2013-11</proposal_call><code>UIP-2013-11-3718</code><acronim><![CDATA[ISTHMUS]]></acronim><duration>01.10.2014 - 30.09.2017</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Split School of Medicine]]></institution_en><team_members_id>3757, 1026, 168, 1395, 194, 599, 4635, 4715, 4581, </team_members_id><team_members_names><![CDATA[Ana Barać , Tonći Batinić, Marko Ljubković, Damir Fabijanić, Jasna Marinović Ljubković, Cristijan Bulat, Mladen Carev, Mihajlo Lojpur, Lemaire Christophe, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[myocardial ischemia, chronic heart failure, cardiac bioenergetics, cardiomyocyte pathophysiology, cardiac imaging]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Coronary artery disease (CAD), with its clinical representations (angina, acute myocardial infarction and chronic heart failure), is the most common cause of morbidity and mortality in developed world. The pathological remodelling occurring in ischemic myocardium gradually leads to chronic contractile dysfunction and affects many intracellular mechanisms participating in energy production, calcium homeostasis and apoptosis. In the current project, we propose to investigate these pathological processes in patients suffering from the CAD. Patients who are candidates for coronary artery bypass graft surgery will be included and will undergo a detailed cardiac evaluation, which, in addition to standard diagnostic tools, will be enriched by the advanced diagnostic techniques still non-existing in Croatia (stress cardiac magnetic resonance imaging). This will provide accurate identification and quantification of regional myocardial ischemia. Following clinical evaluation and during revascularization surgery, left ventricular biopsies will be taken from characterized ischemic regions, as well as from non-ischemic regions, and a detailed analysis of intracellular energy metabolism, calcium-contractility and endoplasmic reticulum stress will be performed. The Specific Aims of the project are:Aim #1 is to assess regional myocardial perfusion and function in patients with CAD who are considered for revascularization therapy.  Aim #2 will investigate pathological processes affecting mitochondria, calcium homeostasis and endoplasmic reticulum stress that take place in the ischemic parts of myocardium.Aim #3 is to evaluate the effects of the heart rate-lowering pharmacological therapy on ischemic myocardium.Thus, the overreaching aim of this proposal is to investigate intracellular mechanisms underlying myocardial adaptation and remodelling in chronic ischemia and to identify predictors of outcomes in patients with coronary artery disease undergoing revascularization therapy. ]]></summary_en></project><project>
<id>2082</id><title_hr><![CDATA[Definiranje uloge cirkadijurnih gena kod bihevioralne senzitizacije na psihostimulanse kod Drosophile melanogaster]]></title_hr><title_en><![CDATA[Defining the role of circadian genes in behavioral sensitization to psychostimulants in Drosophila melanogaster]]></title_en><user_id>69</user_id><user_firstLast_name>Rozi Andretić Waldowski</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-4920</code><acronim><![CDATA[FLYHIGH]]></acronim><duration>01.09.2014 - 31.12.2017</duration><status>Završio</status><financ_value>79.649,26 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci]]></institution_hr><institution_en><![CDATA[University of Rijeka]]></institution_en><team_members_id>5439, 4624, 5961, </team_members_id><team_members_names><![CDATA[Ralph Greenspan, Ana Filošević, Helija Dokić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[addiction, psychostimulants, Drosophila, circadian, genes, screen]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Addiction to drugs is a brain disease characterized by changes in the brain functioning caused by repeated drug taking. Repeated drug taking leads to neuroadaptations which over time affect neural networks and change behavior. One such change induced by drugs and commonly studied in lab animals is behavioral sensitization. Regulation of gene expression is one important mechanism by which drugs change the plasticity of the networks which regulate behavior. A group of transcriptional regulators of the molecular circadian clock have been identified to function as regulators of behavioral sensitization to cocaine in Drosophila. Subsequent studies in rodents proved the universality of those genes in mediating drug responses. The genetic pathways and molecular interactions through which circadian genes regulate drug responses has remained undefined.We hypothesize that new genes which interact with circadian genes in the regulation of behavioral sensitization to psychostimulants can be identified in a genetic screen in Drosophila. This is a goal for which Drosophila is perfectly suited, because genetic screens aimed at defining new genes can be performed relatively easy, fast and cheap. Our first aim is to devise a high-throughput method for measuring behavioral sensitization in flies by modifying the existing method for measuring activity. Second, we will undertake a directed behavioral screen by pre-selecting candidates with reported molecular interaction with circadian genes. In the third aim we will use transgenic flies and other genetic tools to investigate neural mechanisms involved in behavioral sensitization. The proposed research is innovative and relevant for human health. New gene candidates isolated in this screen could easily be translated into mammalian research where they will help in further understanding of neuroplastic changes induced by psychostimulants. Given our expertise and available resources the project has great potential to advance the field.]]></summary_en></project><project>
<id>2094</id><title_hr><![CDATA[Stvaranje socijalističkoga čovjeka. Hrvatsko društvo i ideologija jugoslavenskoga socijalizma]]></title_hr><title_en><![CDATA[Making of the Socialist Man. Croatian Society and the ideology of Yugoslav Socialism]]></title_en><user_id>2955</user_id><user_firstLast_name>Igor Duda</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2013-11</proposal_call><code>UIP-2013-11-1718</code><acronim><![CDATA[Socialist Man]]></acronim><duration>15.06.2014 - 14.06.2017</duration><status>Završio</status><financ_value>65.170,22 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Povijest, </scie_field_hr><scie_field_en>History, </scie_field_en><institution_hr><![CDATA[Sveučilište Jurja Dobrile u Puli]]></institution_hr><institution_en><![CDATA[Juraj Dobrila University of Pula]]></institution_en><team_members_id>3187, 4024, 4494, 3833, 5558, 4286, 4625, 4631, 3429, 4311, </team_members_id><team_members_names><![CDATA[Lada Duraković, Andrea Matošević, Hrvoje Klasić, Snježana Koren, Magdalena Najbar-Agičić, Boris Koroman, Vanessa Vitković Marčeta, Teodora Fonović Cvijanović, Igor Stanić, Anita Buhin, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[socialist society, self-management, ideology in practice, communist indoctrination, Croatia, Yugoslavia]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Making of a “new man” – and woman in the present-day terms – is a concept that has constantly been re-examined and discussed in many political and geographical contexts throughout the twentieth century. The focus of this research project highlights a specific historical situation: the endeavours of Yugoslav authorities in making of a new socialist citizen after the World War II, especially in Croatia as one of the republics forming the Yugoslav Federation. The socialist citizen was first placed in a strongly Soviet-oriented society, but the situation very soon shifted towards a specific kind of Yugoslav self-management and market socialism. The long period of four and a half decades (1945-1990) calls for special attention due to changes in the political system over time: from the formative period of the socialist man to the partial deconstruction of the concept. In many ways Croatia represents an excellent case-study for the research of the Yugoslav society, but in this project it will always be included in the Yugoslav framework and – whenever necessary – in a wider historical context and related comparatively to other socialist societies ruled by communist parties. The academic profile of researchers included in the project guarantees that the new socialist citizen will be closely analyzed in a variety of his or her appearances: from childhood to retirement, in work and leisure or sport, as a creator and a recipient of culture, from the theoretical ideals of high politics to the successful or problematic practices. A wide selection of written, visual and oral sources will be interpreted with a complex multi-disciplinary methodology that includes political, economic, social and cultural history, social and cultural anthropology, cultural studies and linguistics. The aim is to set a new light to the period and topic that are still under-researched by the Croatian and other post-Yugoslav humanities.]]></summary_en></project><project>
<id>2103</id><title_hr><![CDATA[Od protomodernizacije do modernizacije školstva u Hrvatskoj (18. i 19. stoljeće)]]></title_hr><title_en><![CDATA[From Proto-Modernisation to Modernisation of Croatia&#39;s School System (18th and 19th Century)]]></title_en><user_id>232</user_id><user_firstLast_name>Ivana Horbec</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2013-11</proposal_call><code>UIP-2013-11-4919</code><acronim><![CDATA[FPTMOCSS]]></acronim><duration>01.09.2014 - 28.02.2018</duration><status>Završio</status><financ_value>64.874,91 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Povijest, </scie_field_hr><scie_field_en>History, </scie_field_en><institution_hr><![CDATA[Hrvatski institut za povijest]]></institution_hr><institution_en><![CDATA[Croatian Institute of History]]></institution_en><team_members_id>1526, 4458, 1164, 1311, 990, 948, 4836, </team_members_id><team_members_names><![CDATA[Vlasta Švoger, Dinko Župan, Milan Vrbanus, Robert Skenderović, Maja Matasović, Mislav Gregl, Branko Ostajmer, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[History of Education, Intellectual Transfer, Secularisation, Modernisation, State Education Policy, Habsburg Monarchy]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[School system as an educational subsystem of society touches upon and intertwines with political, economic, scientific, cultural, religious and family subsystems of society. In order to be able to understand societal development it is therefore necessary to understand school legislation and educational institutions which, through secondary socialisation, reproduced the desirable normative frameworks for the society within which they operated. Proto-modernisation and modernisation processes implemented during the 18th and 19th centuries were of key importance for forming the school system as an educational system that became an important factor in the emergence of modern civil societies. A research into the problem area of the school system requires a multidisciplinary and interdisciplinary approach that differs essentially from the researches undertaken thus far and closed within the boundaries of the discipline. The objectives of this project proposal are to determine, using modern methodological approaches and critically analyzing archival material, factors that were of crucial importance in the process of creation and functioning of Croatia’s school system and for the influence this system exerted, to evaluate correlation of Croatia’s school system with the school system in the Habsburg Monarchy and its reflection on the network of power in the society in the period of (proto)modernisation. The project will result in three volumes of documents that were of crucial importance for the development of Croatia&#39;s school system, internet database on students studying at higher schools in the Monarchy, interactive map of educational institutions, a workshop for doctoral students, international scientific conference and an exhibition in the Croatian School Museum. One of the objectives of the project is to create prerequisites for expanding international cooperation and including various topics of history of Croatia&#39;s education in internationally funded projects.]]></summary_en></project><project>
<id>2118</id><title_hr><![CDATA[Uloga ekonomskog sentimenta u tumačenju makroekonomskih trendova: metodološka unapređenja i nova područja primjene]]></title_hr><title_en><![CDATA[The role of economic sentiment in explaining macroeconomic trends: methodological improvements and new areas of application]]></title_en><user_id>4299</user_id><user_firstLast_name>Mirjana Čižmešija</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-3858</code><acronim><![CDATA[MCPSIL2484BI]]></acronim><duration>01.09.2014 - 30.09.2018</duration><status>Završio</status><financ_value>67.778,62 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, </scie_field_hr><scie_field_en>Economy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Ekonomski fakultet u Zagrebu]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Economics and Business]]></institution_en><team_members_id>4385, 6252, 5144, 5721, 6268, 21201, </team_members_id><team_members_names><![CDATA[Petar Sorić, Ivana Lolić, Nataša Erjavec, Nataša Kurnoga Živadinović, Vlasta Bahovec, Marina Matošec, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Business and Consumer Surveys, economic sentiment, leading indicators, behavioral economics, nonlinear econometrics]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The aim of this project is to incorporate psychological sentiment (obtained by Business and Consumer Surveys; BCS) in macroeconomic modeling. Namely, BCS offer direct assessment of the otherwise intangible factors such as economic agents’ perceptions and expectations. They measure the agents’ willingness to consume/invest/save, as opposed to their ability to do the same. Hence these psychological factors are crucial to understand the underlying market forces and agents’ behavior. The project goals are to:- Discern whether the non-rationality of consumers’ inflation expectations stems from the true inability of consumers to anticipate price changes, or did the researchers induce it themselves by falsely assuming that the distribution of BCS responses is normal. - Question whether the poor forecasting accuracy of BCS leading indicators can be improved through obtaining the optimal weights by (non)linear optimization.- Compose an optimism indicator based on BCS responses and determine the nature of its relationship with the stock market returns. Nonlinear time series analysis will be employed to test if the stock market reacts asymmetrically to positive/negative shocks in the economic sentiment.- Estimate the consumers’ willingness to buy realty and econometrically model its relationship with actual real estate prices.- Assess the value of BCS responses on households’ financial distress by correlating them to the common measures of poverty.- Employ the BCS data on managers’ perceptions to construct a liquidity indicator for the Croatian economy.The first 5 goals will be fulfilled by analyzing the proposed issues in EU countries, which will improve the general understanding of the role of sentiment in economic decision-making. Each of the stated research fields is expected to result in the publication of a paper in a reputable international journal. The results empirically obtained for Croatia will be synthesized in a scientific book at the end of the project.]]></summary_en></project><project>
<id>2119</id><title_hr><![CDATA[Genska tipizacija patogena prenosivih krpeljima analizom sekvenici više gena: popunjavanje praznina između životinjskih rezervoara, krpelja i ljudi]]></title_hr><title_en><![CDATA[Multilocus sequence genotyping of tick borne pathogens: covering the gap between animals, ticks and humans]]></title_en><user_id>939</user_id><user_firstLast_name>Relja Beck</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2013-11</proposal_call><code>UIP-2013-11-1957</code><acronim><![CDATA[GENOTICKTRECK]]></acronim><duration>01.09.2014 - 31.08.2017</duration><status>Završio</status><financ_value>127.785,52 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Veterinarska medicina, </scie_field_hr><scie_field_en>Veterinary medicine, </scie_field_en><institution_hr><![CDATA[Hrvatski veterinarski institut]]></institution_hr><institution_en><![CDATA[Croatian Veterinary Institute]]></institution_en><team_members_id>2546, 2597, 2599, 4419, 4117, 3369, 4115, 3991, 1341, 3360, 129, 4239, 2528, 2676, 4412, 2743, 2794, 2608, 4328, 529, 538, 1147, 2582, 3510, 2954, 2570, 21273, 1181, </team_members_id><team_members_names><![CDATA[Lorena Jemeršić, Dragan Brnić, Jelena Prpić, Ana Beck, Mirna Brkljačić, Vesna Matijatko, Marin Torti, Sanja Bosnić, Renata Brezak, Irena Reil, Stjepan Krčmar, Alan Medić, Boris Dželalija, Nenad Pandak, OKTAVIJA ĐAKOVIĆ RODE, Željko Mihaljević, Miroslav Benić, Gordan Kompes, Željko Cvetnić, Silvio Špičić, Ivana Račić, Sanja Duvnjak, Boris Habrun, Krunoslav Pintur, Nikica Šprem, DANKO DEŽĐEK, Maja Stepanić, Doroteja Huber, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[tick-borne pathogens, multilocus sequnce genotyping, pathogen distribution, animals, humans]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Globalization and climate change have an unprecedented worldwide impact on emergence and re-emergence of animal diseases, especially vector borne zoonoses.. Diseases that used to be limited only to tropical areas are now increasingly spreading to other previously unaffected regions. A wide variety of pathogens that can be propagated and transmitted by ticks infect humans, wildlife or domestic animals. Over the past decades, the scientific landscape of tick-borne diseases has changed significantly due to advances in molecular biology. Several new rickettsial and ehrlichial diseases, as well as new Borrelia and Babesia genotypes have been confirmed, and consequently, improved diagnostics of emerging diseases in veterinary and human medicine. A number of cases of tick-borne encephalitis (TBE) and Lyme disease have increased. To better understand the importance of tick-borne diseases, a proposed project follows an interdisciplinary approach involving physicians, veterinarians and biologists, also known as One Health approach. Since the cultivation of pathogens is difficult and slow, and for number of pathogens this cultivation is impossible, multylocus sequence typing MLST approach will be used for their genetic characterization of Babesia spp., Borrelia burgdorferi s. l., B. miyamotoi, Rickettsia spp., Anaplasma spp, Ehrlichia spp. Bartonella spp., Neoehrlichia mikurensis, Tick-borne encephalitis virus, Coxiella burnetii and Francisella tularensis from animal reservoirs, ticks and humans. Another objective will be to map tick species, since they were investigated 40 years ago, and to confirm species with PCR and sequencing. Application of genetic typing of multiple genes allows a detailed differentiation of genotypes and their heterogeneity. In this way, the genetic variability of the isolates, their geographical distribution and population genetic structure, as well as transmission routes of various isolates within ticks and their natural reservoirs, will be defined.]]></summary_en></project><project>
<id>2127</id><title_hr><![CDATA[Hrvatska pravosudna suradnja u kaznenim stvarima u Europskoj uniji i regiji: nasljeđe prošlosti i izazovi budućnosti]]></title_hr><title_en><![CDATA[Croatian Judicial Cooperation in Criminal Matters in the EU and the Region: Heritage of the Past and Challenges of the Future]]></title_en><user_id>6266</user_id><user_firstLast_name>Zlata Đurđević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-8282</code><acronim><![CDATA[CoCoCrim]]></acronim><duration>01.03.2015 - 30.09.2019</duration><status>Završio</status><financ_value>77.339,11 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Pravo, </scie_field_hr><scie_field_en>Law, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Pravni fakultet u Zagrebu]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Law]]></institution_en><team_members_id>6296, 6657, 3828, 7404, 7173, 7202, 6110, 816, 6285, 7456, 7529, 18963, </team_members_id><team_members_names><![CDATA[Davor Krapac, Elizabeta Ivičević Karas, Maja  Munivrana Vajda, Stjepan  Gluščić, Marin Bonačić, Petar Novoselec, Marija Pleić, Matko Pajčić, Zoran  Burić, Ante Novokmet, Željko Karas, Ivo Josipović, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[judicial cooperation in criminal matters, european criminal law, criminal prosecution of war crimes, regional cooperation, european arrest warrant]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[General objectives of the project are the improvement of Croatian criminal justice system and the advancement in Croatian legal scientific research in the field of judicial cooperation in criminal matters. The improvement of prosecution will occur as regards: a) cooperation with the EU member states, b) regional cooperation. The advancement of Croatian legal scientific research will be realized through scientific activities of research group composed of senior and young researchers from three Croatian universities specialised in the field of EU, international and regional cooperation in criminal matters. Cooperation in the prosecution of war crimes has been a crucial political and legal issue in Croatia in the past two decades. Presently the focus is moved to cooperation with the EU member states. As judicial proceedings before the ICTY were unsustainable without criminal law cooperation of the States, the effective national criminal prosecution today is as well possible only through realization of full and intensive judicial cooperation with the EU member states. Effective cooperation in the prosecution of serious crimes has multiple political and legal values for Croatia, such as credible membership in the EU, stability in the region, and the protection of human rights. It is crucial for the identification of Croatia as a democratic European state that respects the rule of law and does not tolerate any kind of serious crimes. The outcome of the research will be publication of collection of scientific papers on issues related to forms, institutions and problems of the EU and regional judicial cooperation and the level of compliance of Croatian law, judiciary and case law. The research results will be presented at the public round tables and final conference, and implemented in course curriculum at the Croatian Universities. The project will contribute to the training of six young researches and will strengthen mentoring capacities of Croatian law schools.]]></summary_en></project><project>
<id>2129</id><title_hr><![CDATA[PONOVNA UPORABA MULJA S UREĐAJA ZA PROČIŠĆAVANJE OTPADNIH VODA U BETONSKOJ INDUSTRIJI - od mikrostrukture do inovativnih proizvoda]]></title_hr><title_en><![CDATA[REUSE OF SEWAGE SLUDGE IN CONCRETE INDUSTRY - from microstructure to innovative products]]></title_en><user_id>5991</user_id><user_firstLast_name>Dražen Vouk</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2013-11</proposal_call><code>UIP-2013-11-7927</code><acronim><![CDATA[RESCUE]]></acronim><duration>01.09.2014 - 31.08.2017</duration><status>Završio</status><financ_value>63.640,59 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Građevinarstvo, </scie_field_hr><scie_field_en>Civil engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Građevinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Civil Engineering]]></institution_en><team_members_id>4065, 3406, 6938, 6521, 5060, 6620, 7020, 17785, </team_members_id><team_members_names><![CDATA[Mario  Šiljeg, Nina Štirmer, Davor Malus, Stanislav Tedeschi, Ana Baričević, Lidija Valek Žulj, Christopher Cheeseman, Domagoj Nakić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Wastewater treatment, Sewage sludge, ISSA, Concrete, Microstructure, Sustainable materials]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[In the wastewater treatment process, a by-product is generated, as additional waste called sewage sludge (0.5 kg of sludge per 1 m3 of wastewater). Adequate wastewater management implies collection and treatment of wastewater, but also adequate management of waste substances generated in the treatment process. Joining the European Union Croatia has made the commitment to construct all treatment plants of capacities over 10.000 PE by 2018. This will result in putting into operation of treatment plants with the total load of about 4.000.000 PE (250.000.000 m3 of wastewater), which will generate about 215.000 tons per year of raw sewage sludge and after incineration around 49.000 tons per year of incinerated sewer sludge ash (ISSA). Taking into account that EU Directives are limiting the amount of sewage sludge waste to be landfilled, and Waste Framework Directive (2008/98/EC) puts reuse and recycling of waste into the most favorable position, it is evident that enormous amount of ISSA will become available for appropriate management.The composition of the generated sewage sludge and ISSA is dependent on the technology of wastewater and sludge treatment. Reviewing the available knowledge in this field leads to the conclusion that the influence of the method of incineration on physical properties of ISSA and the technology of preparing and processing of concrete and concrete elements has not been fully analysed. The main objective of the project is to investigate the possibilities of recycling the sludge from WWTPs in preparing of new innovative products in concrete industry. Based on comprehensive experimental research and multidisciplinary knowledge of the partners (hydrotecnical, materials and chemical engineering), a strategy will be proposed for the comprehensive and sustainable management of ISSA and its transformation from unwanted waste material into valuable resource for production of construction products with ecological, economical and technological benefits.]]></summary_en></project><project>
<id>2131</id><title_hr><![CDATA[Genetski mehanizmi lizosomalne disfunkcije u Parkinsonovoj bolesti]]></title_hr><title_en><![CDATA[Genetic mechanisms of lysosomal dysfunction in Parkinson&#39;s disease ]]></title_en><user_id>2684</user_id><user_firstLast_name>Fran Borovečki</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-9386</code><acronim><![CDATA[LYSOGENE PD]]></acronim><duration>15.07.2014 - 14.12.2018</duration><status>Završio</status><financ_value>132.418,78 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>5625, 5619, 5330, 5749, 5959, 4119, 6442, 4818, 19045, 19042, </team_members_id><team_members_names><![CDATA[Zdravka Poljaković, Sanja Hajnšek, Kristina Gotovac, Filip Josip Bingula, Tiago Fleming Outeiro, Maja Relja, Martina Rinčić, Marko Košiček, SRĐANA TELAROVIĆ, Antonela Blažeković, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Parkinson&#39;s Disease, alpha synuclein, next-generation sequencing, lysosomal dysfunction, iPSC]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Accumulation of misfolded proteins in the brain represents a pathological hallmark of neurodegenerative diseases, suggesting that inadequate clearance of aggregation-prone proteins plays an important role in the disease pathogenesis. The synucleinopathies, including Parkinson’s disease (PD) and dementia with Lewy bodies (LBD), are a group of neurodegenerative disorders characterized by the accumulation and aggregation of a-synuclein (aSyn). Studies on the rare inherited forms of PD caused by mutations in the aSyn gene have highlighted disturbed aSyn clearance through the autophagy-lysosomal pathway (ALP) as a key mechanism leading to PD/LBD. Furthermore, several rare inherited disorders caused by mutations in the lysosomal genes show parkinsonian-like phenotype and accumulation of aSyn, providing additional evidence for the role of lysosomal dysfunction in the pathogenesis of synucleinopathies. The goal of the project is to elucidate the involvement of lysosomal gene mutations and lysosomal dysfunction in the ethiology of PD/LBD. Using the next-generation sequencing and Haloplex-based protocol we will design LYSOGENE platform to anayze genetic mutations/variations in the ALP genes that may lead to and predispose to PD/LBD. The identified ALP mutations will be further characterized in vitro in human neuronal cell lines using the knockdown and overexpression approaches. In particular, we will monitor how the identified mutations affect ALP function, accumulation and aggregation of aSyn, as well as neurotoxicity. Finally, we will validate our mechanistic findings in a biologically relevant model of human dopaminergic neurons derived from the PD/LBD patient’s fibroblasts using the induced pluripotent stem cell technology. Through these studies we will identify genetic variations/mutations in the ALP genes that cause or contribute to PD/LBD. The results of the project may help to identify potential new therapeutic targets for development of neuroprotective treatments.]]></summary_en></project><project>
<id>2144</id><title_hr><![CDATA[Algoritmi za analizu slijeda genoma]]></title_hr><title_en><![CDATA[Algorithms for Genome Sequence Analysis]]></title_en><user_id>1480</user_id><user_firstLast_name>Mile Šikić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2013-11</proposal_call><code>UIP-2013-11-7353</code><acronim><![CDATA[AGESA]]></acronim><duration>01.11.2014 - 31.10.2017</duration><status>Završio</status><financ_value>102.561,55 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>7098, 6982, 7322, 18951, 18950, </team_members_id><team_members_names><![CDATA[Niranjan Nagarajan, Damir Seršić, Branko Jeren, Krešimir Križanović, Robert Vaser, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[genome sequence, DNA sequence alignment, RNA-seq mapping, database search, algorithms, GPU]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Twenty years ago, sequencing the human genome was one of the most ambitious science projects ever attempted. Today, DNA and RNA sequencing are now key components of research carried out in many laboratories. The total amount of available genomic data is increasing approximately tenfold every year, a rate much faster than Moore’s Law for computational processing power. The exponential growth of genomic datasets leads to a situation, where computing power becomes a critical issue.The overarching goal of the project is to develop accurate, fast algorithms and tools for analyzing the whole genome-sequencing data. The emphasis of the project is on the output data from the third-generation of sequencing machines that produce longer, more error-prone sequence reads. The basis of the project are sequence alignment algorithms, graph algorithms and signal processing methods. They will be implemented for DNA sequence assembly, sequenced RNA data and sequence similarity database search. The algorithms should feasibly handle data obtained from mammalian and plant genomes (sizes greater than one billion base pairs). Special emphasis will be put on multi-core, many-core and intra-core parallelism. Additionally, the algorithms should provide good scalability over the available underlying computational architecture. All implementations of algorithms will be performed in C/C++. The research will result in the development of novel algorithms tailored to specifications of current and future long-read sequencing data. The implemented methods will further the state-of-the-art of sequence similarity database search, RNA-seq mapping and DNA assembly, ideally providing researchers with methods that return results in feasible time with limited computational resources. This, in turn could affect the current practices of genomic research; help designing new medical strategies and enable faster and more accurate analyses and diagnoses. ]]></summary_en></project><project>
<id>2145</id><title_hr><![CDATA[Anisakis spp: genomska epidemiologija]]></title_hr><title_en><![CDATA[Anisakis spp: genomic epidemiology]]></title_en><user_id>132</user_id><user_firstLast_name>Ivona Mladineo</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-5576</code><acronim><![CDATA[AnGEL]]></acronim><duration>30.06.2014 - 29.06.2018</duration><status>Završio</status><financ_value>113.411,64 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Veterinarska medicina, </scie_field_hr><scie_field_en>Veterinary medicine, </scie_field_en><institution_hr><![CDATA[Institut za oceanografiju i ribarstvo]]></institution_hr><institution_en><![CDATA[Institute of Oceanography and Fisheries]]></institution_en><team_members_id>1192, 1305, 996, 4832, 978, 1111, 1029, 1238, 4601, 1127, 2850, 2621, 3610, 3130, 15951, 13683, </team_members_id><team_members_names><![CDATA[Ivana  Bočina, Ivana Bošnjak, Ivana Bušelić, ESMA ČEČUK-JELIČIĆ, Martina Đuras, Andrea Gudan Kurilj, Ivana Lepen Pleić, Diana Nonković, Mirela Petrić, Vedran Poljak, Ivana Radonić, Ingrid Tripković, Željka Trumbić, Ivana Ujević, Romana Roje Busatto, Jerko Hrabar, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Anisakis spp., zoonosis, seroprevalence, patohistology, transcriptomic, risk analysis]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Global migration and trade of the foodstuff, climate change, novel trends in human eating habits characterised by an elevated demand for raw food, are today considered as major reasons why reports of food borne infections, especially zoonotic parasitosis, have increased in the last decade. Thus the prevention and protection against zoonotic parasites in fishery products designated for human consumption has recently become a priority. Consequently, health authorities and fishing industry have increasingly become aware of the significance of nematode genus Anisakis, which affects human health and the commercial value of fish products. Adriatic fish, marketed fresh, frozen, salted or marinated and exported to EC, are frequently rejected on the border because of Anisakis infection. Although considered one of the most significant emerging food-borne zoonosis, anisakiasis in many Mediterranean countries is still misdiagnosed or underestimated. AnGEL will deepen the knowledge on Anisakis with a multidisciplinary approach, studying the fish as paratenic, cetaceans as the final and men as accidental host. It will start by identifying anisakids species by molecular tools in picarel and damselfish, that are particular dish in culinary tradition of SE Adriatic islands where a significant level of anti-Anisakis IgE in local population was found. It will evaluate histopathological effect of the nematode in the digestive tract of the final host in order to evaluate Anisakis carcinogenic potential, as well as its transciptomic signature during migration through hosts. It will assess larval multixenobiotic resistance mechanisms helping to design more effective therapy, and measure anti-Anisakis seroprevalence in population employed in the fish processing industry by indirect ELISA. Lastly, AnGEL will encompass resulting data in a risk analysis frame, aiming to the design of measures for the safe alimentary seafood production and strengthening of risk communication to stakeholders.]]></summary_en></project><project>
<id>2155</id><title_hr><![CDATA[Istraživanje uloge optineurina u neuroprotekciji]]></title_hr><title_en><![CDATA[Elucidating the Role of Optineurin in Neuroprotection]]></title_en><user_id>4630</user_id><user_firstLast_name>Ivana Munitić </user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2013-11</proposal_call><code>UIP-2013-11-7459</code><acronim><![CDATA[OptineurinNeuroimm]]></acronim><duration>01.09.2014 - 31.12.2017</duration><status>Završio</status><financ_value>131.491,47 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Fakultet biotehnologije i razvoja lijekova]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Biotechnology and Drug Development]]></institution_en><team_members_id>5775, 6187, 6264, 12500, </team_members_id><team_members_names><![CDATA[Hrvoje Jakovac, Kristina Grabušić, Jonathan Ashwell, Andrea Markovinović, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[cell signalling, autophagy, microglia, neurodegeneration, animal models]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Mutations in a widely expressed ubiquitin-binding protein optineurin were recently found in amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease of unresolved pathogenesis. Unlike most of the other mutated proteins known to cause ALS by their toxic prion-like properties, optineurin is largely thought to cause disease by loss-of-function, arguing for its protective role. In vitro studies proposed that it regulates a variety of cellular processes including cell signaling, autophagy and vesicle trafficking, but their link to neurodegeneration is unknown. ALS is not an autonomous disease of selected neurons. Glial cells including microglia, are essential for neuroinflammation, which greatly shapes disease progression. The major aim of this study is to elucidate the exact role(s) whereby optineurin exerts neuroprotection, pinpoint the cell types in which it acts, and determine its putative effect(s) on the interactions between the cell types relevant for neurodegeneration. We aim to dissect these questions in a stepwise fashion by (1) assessing cell-intrinsic functions in neurons, microglia and macrophages, (2) addressing crosstalk in mix-and-match co-cultures and organotypic spinal cord slices, and (3) verifying these findings in mice. To this end, we have generated a novel disease-mimicking genetic mouse model of optineurin insufficiency. Analyzing the function of optineurin in primary cells and mice models is crucial to the success of this study, given that ubiquitin-binding proteins are prone to in vitro artifacts. Incomplete understanding of ALS pathogenesis is directly mirrored in almost complete inability to treat ALS patients: a single approved drug exerts only a small prolongation in survival. Here, we propose to study a unique ALS model, set apart from the currently available models of direct toxicity by its ability to provide insight into basic neuroprotective mechanisms, thus expectedly paving the way for more successful therapies.]]></summary_en></project><project>
<id>2161</id><title_hr><![CDATA[Neomitologizam u kulturi 20. i 21. stoljeća]]></title_hr><title_en><![CDATA[Neomythologism in the Culture of the 20th and 21st Century ]]></title_en><user_id>5143</user_id><user_firstLast_name>Jasmina Vojvodić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-6077</code><acronim><![CDATA[Neomyth]]></acronim><duration>01.09.2014 - 31.08.2018</duration><status>Završio</status><financ_value>73.395,71 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filologija, </scie_field_hr><scie_field_en>Philology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>3595, 6512, 6551, 6853, 18976, </team_members_id><team_members_names><![CDATA[Danijela Lugarić Vukas, Ivana Peruško, Živa  Benčić-Primc, Josip  Užarević, Zoran Tihomirović, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[neomythologism, contemporary science, Russian literature/culture, Croatian literature/culture, myth, everydayness, Slavic Studies, humanities]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Neomythologism in the culture of the 20th and 21st century is a project proposal designed to study one of the basic phenomena in the contemporary culture and science. The relevance of the topic of neomythologism stems precisely from the crisis in fundamental scientific research and reliance on the phenomenon of irrationality which is happening in the contemporary world. Since there is a crisis in the field of major scientific concepts, man tries to look for answers in a new mythology, which is visible in all forms of cultural research (literary text, visual arts, film, discourse of advertising). This is why this project proposal offers launching of a new type of research into neomythologism. The focus of the proposed research is based on the corpus of Russian and other Slavic literatures, including Croatian, in theatre, visual arts, film culture and contemporary media in order to study and define the elements of neomythologizing, especially those of the myths of everyday life (the myth of youth, the myth of the end of the world, the myth of the family, the myth of a healthy diet). Collection of materials, preparation works, workshops and conferences about the myths of everyday life shall take into account all aspects of this challenging topic in order to research this phenomenon, as well as the concept of the mythical in different aspects of Slavic cultures which are historically interconnected with a common mythology. The aim of the project is, hence, to obtain new scientific knowledge about the phenomenon of neomythologism which, though observable, has not scientifically been considered. ]]></summary_en></project><project>
<id>2163</id><title_hr><![CDATA[Ekonomski, statistički i politički aspekti tržišta državnih obveznica]]></title_hr><title_en><![CDATA[Economic, statistical and political aspects of sovereign bond markets]]></title_en><user_id>603</user_id><user_firstLast_name>Maruška Vizek</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2013-11</proposal_call><code>UIP-2013-11-1356</code><acronim><![CDATA[SOBOM]]></acronim><duration>01.09.2014 - 31.08.2017</duration><status>Završio</status><financ_value>55.805,00 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, </scie_field_hr><scie_field_en>Economy, </scie_field_en><institution_hr><![CDATA[Ekonomski institut Zagreb]]></institution_hr><institution_en><![CDATA[Institute of Economics in Zagreb]]></institution_en><team_members_id>790, 1066, 733, 606, 983, 17742, </team_members_id><team_members_names><![CDATA[Bojan Basrak, Josip Glaurdić, Petra Posedel, Marina Tkalec, Goran Vukšić, Petra Palić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Sovereign bond market, sovereign spreads, volatility spillovers, sovereign bond market integration stochastic volatility models, extreme value theory,]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Recent developments related to the Eurozone debt crisis clearly demonstrated the inability of the literature to provide a theory and associated empirical models that can explain the past and predict the future sovereign bond yield changes. Therefore in this research we investigate the features of the sovereign bond markets that are either underexplored or the literature offers conflicting findings. We focus specifically on bond markets in all EU member states and the US, and differentiate seven research segments that are mutually interrelated. First segment applies GARCH-type models and estimates sovereign bond spread volatility and the volatility risk premium. The output of this segment is used in subsequent segments; in the model of spread determinants, volatility spillovers, and capital flight. Second segment is dedicated to the analysis of the statistical properties of sovereign spreads volatility by an application of extreme value theory, self-exciting and Markov switching models. We quantify extremal dependence between spreads and the distribution of  clusters of their extreme movements using the extremogram. Two segments are devoted to the analysis of volatility spillovers across bond markets and time-varying degree of sovereign bond market integration in developed and emerging EU countries. We also analyze political factors that may influence the sovereign bond market and cross-border capital movement. In this segment we code political variables employed as explanatory variables in the remaining two segments. Hence segment six estimates the model of spread determinants that includes a more balanced and detailed representation of market sentiment and volatility, fiscal features, and political factors. Due to the fact that in recent times extreme changes in sovereign bond markets induced cross-border reallocation of the capital, in the seventh segment we estimate a capital flight model that includes political factors and sovereign spread volatility premium.]]></summary_en></project><project>
<id>2165</id><title_hr><![CDATA[Kulturološke, ekonomske, monetarne i društvene promjene u svjetlu arheološke baštine srednjeg Podunavlja između 279. g. pr. Kr. i 582. g.]]></title_hr><title_en><![CDATA[Cultural, economic, monetary and social transformations in view of the archaeological heritage of the Middle Danubian region 279 B.C. – A.D. 582]]></title_en><user_id>2800</user_id><user_firstLast_name>Tomislav Bilić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-1549</code><acronim><![CDATA[ECMS]]></acronim><duration>15.06.2014 - 14.06.2018</duration><status>Završio</status><financ_value>75.784,72 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Arheologija, </scie_field_hr><scie_field_en>Archeology, </scie_field_en><institution_hr><![CDATA[Ništa od navedenog]]></institution_hr><institution_en><![CDATA[Nothing from this list]]></institution_en><team_members_id>2868, 2804, 4660, 2860, 6690, </team_members_id><team_members_names><![CDATA[Ivan Mirnik, Miroslav  Nađ, Ivan Radman-Livaja, Anja Bertol, Ivan Drnić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Middle Danube region, Pannonia, Roman archaeology, numismatics, La Tene period,  Archaeological museum in Zagreb]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The main goal of the CEMS project would be to focus on the numismatic and archaeological heritage of a geographical area in a given time-frame, i.e. the Middle Danube region from the La Tene B period till the Great Migrations period (between two symbolic dates, 279 B.C., the arrival of the Celts in the Danube basin, and A.D. 582, the fall of Syrmium). Four of the Zagreb Archaeological Museum’s departments have an extremely large number of artefacts from this period found in this particular region, most of which remain unpublished and require a thorough scientific assessment. Therefore, the main emphasis of the project would be on the study and publication of the material kept in the holdings of the Museum.The principal results of the CEMS project would be to publish up to ten monographs on the archaeological and numismatic heritage of the Middle Danube region within a given time frame. These publications would not merely be catalogues of material but would aim to present, following modern methodological approaches in archaeology, ancient history and numismatics, all the cultural, social, economical, monetary and technological transformations that occurred over that fascinating period in a defined geographical area.]]></summary_en></project><project>
<id>2176</id><title_hr><![CDATA[Strateško korištenje prostora]]></title_hr><title_en><![CDATA[Strategic use of landscape]]></title_en><user_id>6496</user_id><user_firstLast_name>Zorko Marković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-3700</code><acronim><![CDATA[Stratuselandscape]]></acronim><duration>01.07.2014 - 30.09.2016</duration><status>Završio</status><financ_value>31.853,47 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Arheologija, </scie_field_hr><scie_field_en>Archeology, </scie_field_en><institution_hr><![CDATA[Institut za arheologiju]]></institution_hr><institution_en><![CDATA[Institute of Archaeology in Zagreb]]></institution_en><team_members_id>6516, 6838, 7440, 7392, </team_members_id><team_members_names><![CDATA[Katarina Botić, Danimirka Podunavac, Kornelija  Minichreiter, Hrvoje Kalafatić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[field survey, trial excavation, landscape archaeology, natural resources, Drava region]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Landscape archaeology is developing slowly in Croatia. It is of great importance to speed up this process and to connect the available data to other regions in central-eastern Europe. It is especially important to connect central Balkan regions with Carpathian basin for better understanding of emergence and development of societies in various prehistoric periods. So far, the ways of communication between these regions were not of primary interest of archaeological scientific work. The complete work in defined area, combining field survey, trial excavations and data concerning natural resources, hasn’t been done. The goal of this project is the recognition of strategic points of settlement in prehistory and later periods and reconstruction of ways of communication. The project will concern itself with the area of municipalities Našice, Podgorač, Drenje and Koška (Drava region). This area is recognized as a potential crossroad of ways of communication of our interest. The work will be divided into 4 stages including field survey, trial excavations, data collection from geological maps and satellite images, combining data, web site construction and presenting the results in form of exhibitions, conferences, lectures etc. The final publication will be made presenting goals, collected data, the final results and list of museum activities. The results will also be available on-line in the form of a web site. The project is planned in collaboration with Našice Local History Museum.]]></summary_en></project><project>
<id>2178</id><title_hr><![CDATA[Aktivacijski receptori NK-stanica specifični za virus i njihovo izbjegavanje od strane virusa]]></title_hr><title_en><![CDATA[Virus-specific Activating NK Cell Receptors and Their Viral Immunoevasion]]></title_en><user_id>4958</user_id><user_firstLast_name>Astrid Krmpotić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-7132</code><acronim><![CDATA[ViSpeNKRec]]></acronim><duration>01.07.2014 - 31.10.2018</duration><status>Završio</status><financ_value>113.212,56 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Medicine]]></institution_en><team_members_id>5273, 4682, 5131, 4723, 4834, 5357, 4652, 17754, 23184, </team_members_id><team_members_names><![CDATA[Irena Slavuljica, Vanda Juranić Lisnić, Johanna Reichel, Branka Popovic, Ilija Brizić, Daria Kveštak, Berislav Lisnić, Jelena Železnjak, Mia Cesarec, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[NK cells, cytomegalovirus, immunoevasion, Ly49 receptors, KIR receptors, transcriptomics]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The infection of mice with mouse cytomegalovirus (MCMV) as a model of human CMV (HCMV) infection has been particularly informative in elucidating the role of antiviral immune response. NK cells are essential in early control of CMV infection. An evolutionary struggle between NK cells and CMVs can be inferred from a numerous viral mechanisms designed to compromise NK cell function. A deeper insight was gained by studying MCMV evasion of ‘missing-self’ mechanisms and host response to this immunoevasion, illustrated by several MCMV-specific NK cell activating receptors. The work on Ly49H receptor emphasized the selective pressure imposed on the virus to generate variants no longer recognized by this receptor. Another example can be seen from the function of viral m04 protein, which binds to newly synthesized MHC-I molecules and escorts them to the cell surface to engage inhibitory Ly49 receptors. However, while m04 prevents NK cell activation by escaping ‘missing-self’ recognition, several activating Ly49 receptors also depend on its presence for their own recognition of infected cells. Beside m04, another so far unidentified viral factor is required for turning on the activating Ly49 receptors. In addition to characterization of this new viral gene, the aim of this study is to elucidate the functional significance of MCMV-specific activating Ly49 receptors and their interaction with inhibitory counterparts during primary and latent infection.Ly49 receptors in mice are functional homologues of KIR receptors in humans. Recent studies also indicate a strong impact of HCMV on the repertoire and frequency of activating KIR-expressing NK cells, suggesting their specific response to this virus. Therefore, in addition to the MCMV genes involved in ligation of activating Ly49 receptors, here we also propose study aimed to characterize HCMV gene(s) involved in ligation of activating KIRs. We expect these studies to provide new data of groundbreaking potential in the field.]]></summary_en></project><project>
<id>2179</id><title_hr><![CDATA[3D sustav za mjerenje oblika trupa tijela]]></title_hr><title_en><![CDATA[A low-cost automated system to measure the three-dimensional shape of trunk surface]]></title_en><user_id>6456</user_id><user_firstLast_name>Tomislav Pribanić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-3717</code><acronim><![CDATA[3DHumanTorso]]></acronim><duration>03.11.2014 - 02.11.2017</duration><status>Završio</status><financ_value>96.622,20 eur</financ_value><scie_area_hr>Tehničke znanosti, Biomedicina i zdravstvo, </scie_area_hr><scie_area_en>Technological sciences, Biomedicine and health sciences, </scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>6749, 17809, 6641, </team_members_id><team_members_names><![CDATA[Stanislav Peharec, Matea Đonlić, Tomislav Petković, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[3D reconstruction, structured light, passive stereo, scoliosis, degenerative disease, 3D  spine shape]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The aim of this work is to develop a low-cost automated system to measure the three- dimensional shape of the back and front of the human torso. It will enable numerous physicians to acquire the trunk surface (TS). TS symmetry is one of the key elements in diagnostic and evaluation of various treatments in patients with trunk deformities. Common radiographic evaluation methods are known to expose patients to a radiation and, besides, radiography is actually 2D representation of 3D problem which has been shown not to be directly related to the shape of the back. Thus, there has been a constant motivation among researchers at (inter)national level to develop an optimal methodology for 3D reconstruction of the back. Still, most of those developed systems are mainly directed to 3D reconstruction of the spine and calculation of the Cobb angle which is still regarded by many as the gold standard method to measure scoliotic deformity. Still, the Cobb angle alone cannot explain the whole of the surface deformity. Evidently, there is high need to investigate development of a 3D reconstruction system which will capture both back and front of the patient, i.e. the entire trunk surface. In turn it would enable a more thorough analysis of the patient’s deformity pattern, i.e. a second major goal during this project is to derive other parameters (not only Cobb angle) in order to quantify trunk deformities. In designing 3D system we underline that we plan to research the implementation of both passive and active stereovision strategies. Researching the implementation of combined best features from passive and active stereo for one concrete of 3D system aimed at TS reconstruction (scoliosis), would be a great contribution for potential other 3D applications. Degenerative diseases of spine represent a serious social problem in Croatia. More than 10% of population has frequent problems with it. Clearly, every research contribution for this matter would be an extremely valuable asset.]]></summary_en></project><project>
<id>2182</id><title_hr><![CDATA[Jezična obrada u odraslih govornika]]></title_hr><title_en><![CDATA[Adult language processing]]></title_en><user_id>400</user_id><user_firstLast_name>Jelena Kuvač Kraljević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2013-11</proposal_call><code>UIP-2013-11-2421</code><acronim><![CDATA[ALP]]></acronim><duration>15.09.2014 - 14.09.2017</duration><status>Završio</status><financ_value>52.312,92 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Logopedija, </scie_field_hr><scie_field_en>Logopedics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Edukacijsko-rehabilitacijski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Education and Rehabilitation Sciences]]></institution_en><team_members_id>4359, 6147, 6436, 3759, 3050, 5429, 17791, 20388, </team_members_id><team_members_names><![CDATA[Marijan Palmovic, Gordana Hržica, Melita Kovačević, Sanja  Šimleša, Magdalena Krbot Skoric, KAROLINA LICE, Marina Olujić, Ana  Matić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[language processing, adult and elderly population, language disorders, executive functions, linguistic aphasiology]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Adult Language Processing project is intended to address psycholinguistic and neurolinguistic aspects of the aging population in Croatia. As an installation research project it will help set up an interdisciplinary and multidisciplinary research group that would tackle all aspects of the language processing in adults and in the aging population. Clinical groups (patients with aphasias, dementias and dyslexia) will be included into the project; language breakdown in these clinical groups helps in the study of language processing in healthy adults and vice versa. It is generally assumed that the subtle changes in language processing in the aging population arise from the cognitive decay related to executive functions, not language per se. The decrease in the processing speed influences language processes that require fast execution or simultaneity. This results in a typical pattern of changes, different from the ones in clinical populations. Therefore, executive functions in these groups will be studied in order to build a comprehensive model of adult language processing. Theories of language processing (namely, Role and Reference Grammar - RRG) will be considered to define specific traces of language processing that assume fast execution or simultaneity and therefore should be the most vulnerable in aging population. These traces will be defined and described which will put Croatian into a cross-linguistic perspective in contemporary studies of linguistic aphasiology and provide coherent picture of age related changes in adult language system.  ]]></summary_en></project><project>
<id>2184</id><title_hr><![CDATA[Problemi temeljnoga suvremenog glazbenog nazivlja u Hrvatskoj]]></title_hr><title_en><![CDATA[Problems of Basic Contemporary Musical Terminology in Croatia]]></title_en><user_id>1454</user_id><user_firstLast_name>Nikša Gligo</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-5355</code><acronim><![CDATA[conmusterm]]></acronim><duration>08.09.2014 - 07.09.2018</duration><status>Završio</status><financ_value>37.162,39 eur</financ_value><scie_area_hr>Humanističke znanosti, </scie_area_hr><scie_area_en>Humanities, </scie_area_en><scie_field_hr>Filologija, </scie_field_hr><scie_field_en>Philology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Muzička akademija]]></institution_hr><institution_en><![CDATA[University of Zagreb, Music Academy]]></institution_en><team_members_id>3664, 3395, 5984, 2897, </team_members_id><team_members_names><![CDATA[Tomislava Bošnjak Botica, Krešimir Sučević-Međeral, Sanja Kiš Žuvela, Ana Ostroški Anić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[musical terminology, Croatian standard language, music education, language standardization, corpus analysis, comparative terminology]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The project will be dealing with the basic problems of contemporary musical terminology in Croatia.  Aware of the high cultural value of the state-funded music education system in Croatia, as well as an indispensable role of musical metalanguage in teaching music at all levels, the PI Nikša Gligo has noticed an array of doubtful basic musical terms appearing within the above mentioned system. The discrepancies among teaching professionals are so present that it often comes to misunderstandings and other difficulties in communication. The objectives of the project will be to locate problems through analysis of recent corpus of professional literature in the field, to analyse the variants in the use of musical metalanguage among teaching professionals, to compare the Croatian musical terminology with other languages, as well as to propose alternative solutions for inappropriate basic musical terms in daily use. The main aim of the project is to make available to public a set of 2000 standardized and harmonized basic musical terms in form of a free internet database and a published handbook. Further dissemination will follow in form of terminology workshops and seminars throughout Croatia. This interdisciplinary project will be achieved through intensive cooperation of musicologists and linguists, which will ensure a high level of linguistic normativity along with musicological aptness. The PI Gligo is a frequent speaker and the leading author on musical terminology in Croatia.]]></summary_en></project><project>
<id>2185</id><title_hr><![CDATA[STRUKTURNA OBILJEŽJA KOJA ODREĐUJU NUKLEOFUGALNOST IZLAZNIH SKUPINA TE TEORIJSKI MODEL ZA PROCJENU SOLVOLITIČKE REAKTIVNOSTI]]></title_hr><title_en><![CDATA[STRUCTURAL FEATURES THAT DETERMINE THE NUCLEOFUGALITY OF LEAVING GROUPS AND THE THEORETICAL MODEL FOR ESTIMATING THE SOLVOLYTIC REACTIVITY]]></title_en><user_id>2610</user_id><user_firstLast_name>Olga Kronja</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-1021</code><acronim><![CDATA[NUCLEOFUGALITY]]></acronim><duration>01.07.2014 - 30.09.2018</duration><status>Završio</status><financ_value>74.285,34 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Farmaceutsko-biokemijski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Pharmacy and Biochemistry]]></institution_en><team_members_id>3221, 3453, 3505, 3946, </team_members_id><team_members_names><![CDATA[Bernard Denegri, Mirela Matić, Sandra Jurić, Marijan Marijan, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[nucleofugality, electrofugality, kinetics, solvolysis, reactivity]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The impact of electronic effects in the leaving group (nucleofuge) on the overall reactivity will be investigated thoroughly. Importance of negative hyperconjugation, contribution of the leaving group to the height of the reaction intrinsic barrier, importance of the inductivity and resonance as well as solvation will be analyzed. Series of substituted phenyl and alkyl carbonates, phosphates, phenolates, sulfates, phosphorous ylides, quaternary ammonium salts, etc. will be subjected to solvolysis in aqueous solvents and the rate constants will be correlated with the electrofugalities of the generated carbocations by applying a special LFER equation: log k = sf (Nf + Ef). To detect changes of the C—H bond strength in the TS, secondary deuterium KIEs will be determined. The rates of the backward combination reactions in some cases will be measured, which will provide a complete free energy profile of some reactions. The Marcus intrinsic barriers will be calculated and analyzed. The existing electrofugality scale will be extended with other aromatic (e.g. ferocenyl) as well as non-aromatic electrofuges by introducing the correction factors for the solvolysis rates. Such extended electrofugality scale, not limited to aromatic derivatives only, will allowed estimation of the heterolysis rates for wide range of compounds.	The quantum-chemical model will be developed which mimics heterolysis reactions and whose barriers for variety of leaving groups correlate well with experimental barriers obtained with benzhydryl derivatives (?G‡calc vs ?G‡exp). By applying this correlation, the nucleofugality scale will be extended considerably and estimation of the rate constants for SN1 solvolysis of numerous leaving groups will be enabled. Such interplay of the theoretical calculations and experiment will allow prediction of the reactivity of a huge number of new nucleofuges, which have not been used earlier, as well as design of the substrates with required reactivity.]]></summary_en></project><project>
<id>2187</id><title_hr><![CDATA[Dubrovnik: Civitas et Acta Consiliorum, Vizualizacija razvoja kasnosrednjovjekovnog urbanog tkiva]]></title_hr><title_en><![CDATA[Dubrovnik: Civitas et Acta Consiliorum, Visualizing Development of Late Medieval Urban Fabric]]></title_en><user_id>431</user_id><user_firstLast_name>ANA PLOSNIĆ ŠKARIĆ</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2013-11</proposal_call><code>UIP-2013-11-9492</code><acronim><![CDATA[DUCAC]]></acronim><duration>01.10.2014 - 30.09.2017</duration><status>Završio</status><financ_value>52.943,13 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Povijest umjetnosti, </scie_field_hr><scie_field_en>Art history, </scie_field_en><institution_hr><![CDATA[Institut za povijest umjetnosti]]></institution_hr><institution_en><![CDATA[Institute of Art History, Zagreb]]></institution_en><team_members_id>6995, 5352, 5998, 5497, 7130, 5555, </team_members_id><team_members_names><![CDATA[Nada Grujić, Donatella Calabi, Danko Zelić, Ana Marinković, Alessandra Ferrighi, Matko Matija Marušić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[new archival data, urban development, changes of tissue, dissemination, comparative perspective, general public, new digital technologies]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The aim of the DUCAC project is to establish an international, Croatian-Italian group of urban history researchers that would participate in the work, research and discussions within the international community of humanities and social sciences. The project&#39;s main goal is to systematically investigate the unpublished 15th century archival records of Dubrovnik&#39;s three governing bodies (Great Council, Minor council and the Senate) in order to select, gather, interpret and publish data concerning urban spaces and buildings and to examine the relationships between Councils’ deliberations and the urban development. The results would be discussed within the comparative perspective regarding the similar topics of other European towns as well as disseminated within scientific community and general public. These objectives would be established using new digital technologies for the humanities - HGIS interactive database and 3D visual presentations of the related processes.]]></summary_en></project><project>
<id>2189</id><title_hr><![CDATA[Organske molekule u kondenziranoj fazi: međudjelovanja i modeliranje]]></title_hr><title_en><![CDATA[Organic molecules in condensed phase: interactions and modeling]]></title_en><user_id>4668</user_id><user_firstLast_name>Hrvoj Vančik</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-7444</code><acronim><![CDATA[ORGMOL]]></acronim><duration>01.09.2014 - 30.11.2018</duration><status>Završio</status><financ_value>99.731,17 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>4679, 4656, 4669, 5069, 4687, 19061, </team_members_id><team_members_names><![CDATA[Zlatko Mihalić, Ivana Biljan, Ivan Kodrin, Igor Rončević, Katarina Varga, Petar Bibulić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[reaction mechanisms, solvent effects, solid-state reactions, molecular self-assembly, nitroso compounds, ferrocenes]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[This research will consist of two parallel research pathways. The first will include study of mechanisms of organic reactions in the solid state, and the second will mainly deal with the theoretical study of mechanisms in the solution.Mechanisms of the solid-state processes cannot be interpreted using the established concepts of reaction mechanisms because the phase change plays the crucial role in determining reaction kinetics and the structure of the products. Until now, papers published in this field represent mostly kinetics of phase transformations and descriptions of kinetic data by various mathematical models. As a result, the relationship between such a macroscopic approach and structural changes on the molecular level is still poorly understood. Knowledge about the principles of solid-state reactions is of broad interest, and especially useful to chemists who use solvent-free synthetic methods. In this research, we propose investigations of solid-state reactions based on our recent discoveries and explanations of mechanisms of dimerizations and polymerization of nitroso compounds. Using this established approach and corresponding molecular models, we plan to develop a mechanistic concept of the solid-state reactions, and use it to design novel supramolecular structures.As a starting point of our investigations of organic reaction mechanisms in the solution, we will finish development of our new cluster-continuum solvation model. It will provide us with the most important solute-solvent molecules clusters, allowing the realistic estimates of standard Gibbs energies of involved species and thus prediction of kinetic and thermodynamic data for the examined reactions. The approach will be tested on several model problems, and then used for the analysis of several representative organic mechanisms, including the ones occurring in solids.]]></summary_en></project><project>
<id>2193</id><title_hr><![CDATA[Histološka, MRI i analiza genske ekspresije reorganizacijskih procesa u medijalnom (limbičkom) zidu ljudskog mozga tijekom razvitka]]></title_hr><title_en><![CDATA[Histological, MRI and gene expression analysis of the reorganizational processes in the medial (limbic) wall of developing human cerebrum]]></title_en><user_id>3523</user_id><user_firstLast_name>Mario Vukšić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-7379</code><acronim><![CDATA[MEDCEREB]]></acronim><duration>01.09.2014 - 31.08.2018</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>6256, 4298, 5534, 4125, 17812, 23386, 22600, </team_members_id><team_members_names><![CDATA[Nataša Jovanov Milošević, Milan Radoš, Zeljka Krsnik, Goran Sedmak, Vinka Kovačević, Damir Mulc, Mihaela Bobić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[subplate, marginal zone, human brain development, immunohistochemistry, gene expression, in situ hybridization, MRI analysis, hippocampus, cingulum]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The salient feature of the human fetal cortex is the presence of the subplate zone (SP), a prominent, synapse rich compartment composed of „waiting“ afferents, loosely arranged axons, synapses, growth cones, migratory neurons, glial cells and extraordinary amount of extracellular matric molecules (ECM). The medial (limbic) cortical regions (areas involved in emotion and memory functions) develop a different laminar structure in comparison with lateral cortical regions. Unlike the lateral cortex, where the SP is a major site of neurogenetic events, in the medial archicortex marginal zone (MZ) seems to be a key zone for early molecular neuronal interactions, synaptogenesis and patterning of growing pathways. The goal of this project is to correlate developmental reorganization of major cellular (cell bodies, growing axons) components of the SP and the MZ in developing medial wall of the human cerebrum (cingulum, hippocampus, amygdala) by combining immunochistochemistry, in situ hybridization, transcriptome analysis with in vivo/in vitro MRI. Histological analysis wiil be performed on postmortem human brains, ranging from 10 postconceptional weeks (POW) to 6.5 years, to analyze the expression patterns of different developmentally regulated proteins in relation to synaptic, laminar, neuronal, glial and ECM development. These results will be correlated with in vivo/in vitro MRI findings obtained in age-matched fetuses, infants and children. In addition, we will also analyze publicly available gene expression database (Kang et al., 2011) to investigate the relationship between structural changes and spatio-temporal expression of specific candidate genes. For the selected candidate genes we will perform in situ hybridization and immunocytochemistry in order to elucidate in which cells are these genes expressed. The obtained data will be used for setting the baseline for studying developmental abnormalities characteristic for diverse neurological disorders]]></summary_en></project><project>
<id>2194</id><title_hr><![CDATA[Precizna mjerenja svojstava hadronskih sustava i niskoenergijska QCD]]></title_hr><title_en><![CDATA[High precision measurements of hadronic system properties and low energy QCD]]></title_en><user_id>3809</user_id><user_firstLast_name>Damir Bosnar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-1680</code><acronim><![CDATA[PExpQCD]]></acronim><duration>01.07.2014 - 30.06.2018</duration><status>Završio</status><financ_value>109.230,87 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>4395, 4413, 5059, 4909, 4993, </team_members_id><team_members_names><![CDATA[Ivica Friščić, Petar Žugec, Gorjana Jerbić-Zorc, Ulrich Müller, Catalina Oana Curceanu, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[electron scattering, nucleon structure, NN correlations, kaonic atoms, low energy QCD]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[In the focus of the project are high precision measurements of specific hadronic system properties relevant for the low energy QCD: electron scattering investigations of nucleons and nuclei at Mainz Microtron (MAMI) and X-ray transitions in kaonic atoms at DAPHE at Laboratori Nazionali di Frascati (LNF). The ultimate goal of the proposed experiments, together with other experimental and theoretical investigations, is to provide crucial pieces of information for the understanding how hadrons emerge from their fundamental constituents - the quarks and gluons, why the colour is confined, the symmetry is spontaneously broken and the nucleon is much heavier than its constituents. The main objectives in electron scattering experiments at MAMI are: cross section determination of the p(e,e’ ?+)n reaction at Q2=0.078 (GeV/c)2, the lowest measured value till now, of crucial relevance for axial nucleon form factor determination, measurements of virtual Compton scattering in the momentum transfer range of relevance for nucleon structure determination, investigations of 12C(e,epp)10Be and  simultaneous measurement of 12C(e,epp)10Be and 12C(e,e’pn)10B reactions of relevance for determination of the role of quark degrees of freedom in nuclei and also for understanding of cold dense nuclear systems such as neutron stars. The main objectives in the kaonic atoms experiments at LNF are: upgrade of SIDDHARTA setup in order to reach desired resolution and subsequently high precision measurements of transitions in kaonic deuterium, 3He and 4He, that should yield isospin dependent kaon-nucleon scattering lengths. Their precise determination will put strong constraints on the low-energy kaon-nucleon dynamics and eventually constrain the SU(3) description of chiral symmetry breaking. Important component of the project proposal is also development of new detector systems, in particular silicon detector system and diamond detector system with data acquisition based on fast digitizers.]]></summary_en></project><project>
<id>2195</id><title_hr><![CDATA[Razvoj naprednih visokonaponskih sustava primjenom novih informacijskih i komunikacijskih tehnologija]]></title_hr><title_en><![CDATA[Development of advanced high voltage systems by application of new information and communication technologies]]></title_en><user_id>5632</user_id><user_firstLast_name>IVO UGLEŠIĆ</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-9299</code><acronim><![CDATA[DAHVAT]]></acronim><duration>01.09.2014 - 31.08.2018</duration><status>Završio</status><financ_value>63.504,94 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>3614, 5633, 3670, 1373, 6159, 6804, 6797, 5760, </team_members_id><team_members_names><![CDATA[Viktor Milardić, Božidar  Filipović-Grčić, Boško Milešević, Dalibor Filipović-Grčić, Bojan Franc, Ivica Pavić, Bruno Jurišić, Milivoj Mandić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[high voltage, electric raliway, power quality, EMC, modelling, ICT]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The Research Project will develop the following implementation of new ICT technologies in High Voltage systems: 1. Application of new information and communication technologies such as lightning location system data for analysis of lightning overvoltages and overvoltage protection optimization:- Develop an original algorithm for lightning location data analyze in order to determinate the lightning flashes from the lightning strokes. - Analyze of collected lightning location date and develop an original algorithm for correlation with protection relay tripping in transmission and distribution lines. 2. Modeling the consumers with a big influence on the power quality in high voltage system- Influence of electric railway system on power quality in 110 kV transmission system.- Model of 25 kV 50 Hz electric railway system for power quality studies (electric locomotive, traction network, traction substation):- Compare the developed model with measurement results obtained on locomotives, electric trains and in electric traction substations.  3. New methods for the assessment of Electromagnetic Compatibility - Methodology for more precise electromagnetic influence calculation of contact line and electric traction system to the metal structure in the vicinity:- Identification and assessing the effect of changing values of model parameters based on the theory of electrical circuits to calculate the induced voltage.4. New models of components in studies of electromagnetic transients in high voltage systems- Development of wideband models for power system components (power and instrument transformers, circuit breakers, surge arresters, shunt reactors).- Summarize and analyze the detailed bibliography on the high frequency electromagnetic behavior of transformers (calculations and measurements). - High frequency transformer modeling.]]></summary_en></project><project>
<id>2203</id><title_hr><![CDATA[Upotreba cijelog genoma mitohondrijske DNA u oplemenjivanju i konzervacijskoj genetici goveda]]></title_hr><title_en><![CDATA[Utilisation of the whole mitogenome in cattle breeding and conservation genetics]]></title_en><user_id>6650</user_id><user_firstLast_name>Ino Čurik</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-9070</code><acronim><![CDATA[MitoTAUROmics]]></acronim><duration>01.07.2014 - 30.10.2018</duration><status>Završio</status><financ_value>121.093,37 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Agronomski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Agriculture]]></institution_en><team_members_id>4140, 6553, 7105, 539, 6279, 7067, 7343, 7372, 7206, 7401, 17837, 19007, 1339, 6771, 7242, </team_members_id><team_members_names><![CDATA[Strahil Ristov, Anamarija Smetko, Johann Sölkner, Nikola Raguž, Maja Ferenčaković, Ivana Kovač, Vlatka Čubrić Čurik, Mato Čačić, Gregor Gorjanc, Antun Kostelić, Martin Reljanović, Vladimir Brajković, Dinko Novosel, Marija Špehar, Dragica Šalamon, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Whole mitogenome, Cattle, Detrimental effects, Phenotypic variability, Quantitative genetics]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The main goal of this proposal is to sequence mitochondrial whole genome (mtWGS) in a 500 to 600 bulls or cows (440 to 540 belonging to Istrian cattle, Busha cattle, Slavonian-Syrmian Podolian cattle and Holstein population in Croatia) in order to: 1). identify polymorphic sites within mtWGS in genetically small populations and to analyse (confirm) the presence of selection for the whole mitochondrial genome as well as for each single gene (comparison of non-synonymous versus synonymous mutations); 2). Identify potentially detrimental mutations and to estimate detrimental load in all analysed populations; 3.) develop computerised approach (set of algorithms) that will, in terms of probability or likelihood, enable imputation of sequenced mtWGS haplotypes for other pedigree members as well as to point to animals that are wrongly assigned to the pedigree, 4.) Identify mutations that are associated with phenotypic variability of milk production and fertility traits and to estimate the magnitude of the mtWGS effects (haplotypes) in terms of variance components and 5.) Identify private (specific) mutations that can be used in traceability or genetic bar-coding of species and breeds (this is of particular interest for endangered populations). In performing these comprehensive analyses we will use newly developed methodologies of high-throughput sequencing and complex computing analyses. We believe that this research will stimulate other researchers involved in animal genetics and breeding of other species (dog, horse, swine, rabbit, etc…) for similar researches. Furthermore, results of the project will be economically utilised in cattle breeding as well as conservation management of endangered Croatian breeds. At the same time, we hope that innovative and technologically advanced component of this research will result in good publication record for all scientists involved which will further increase our competitiveness to approach to EU funded projects.]]></summary_en></project><project>
<id>2209</id><title_hr><![CDATA[Antički vodni sustavi grada Salone i Dioklecijanove palače i njihov utjecaj na održivost urbane sredine]]></title_hr><title_en><![CDATA[Roman Water Systems of City of Salona and Diocletian&#39;s Palace and Their Impact on Urban Sustainability]]></title_en><user_id>6669</user_id><user_firstLast_name>Jure Margeta</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-9852</code><acronim><![CDATA[RWSCSDP]]></acronim><duration>01.09.2014 - 31.12.2018</duration><status>Završio</status><financ_value>77.178,31 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Arhitektura i urbanizam, </scie_field_hr><scie_field_en>Architecture and Urban Environment, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu Fakultet građevinarstva, arhitekture i geodezije]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Civil Engineering, Architecture and Geodesy]]></institution_en><team_members_id>6671, 6575, 6674, 6871, </team_members_id><team_members_names><![CDATA[Katja Marasovic, Snježana Perojević, Miroslav Katić, Davor Bojanić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Urban water system, Salona, Diocletian&#39;s palace, Aqueduct, Sewage]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The aim of the project is to study two Roman Water Systems which are using the same water source - Jadro spring. First one is Water System of Salona, capital of Roman province Dalmatia, from the 1st century, and the second one is of Diocletian&#39;s Palace in Split from 4th century. The study will consist of analysis and reconstruction of two, by its purpose, different Water System, one of typical urban character and another very specific of Emperor Palace. Unlike the Water System of the Palace, which is partly preserved (aqueduct is in function) and therefore more studied, the Water System of Salona is mostly unknown. They will be studied separately using the same methodology.All parts of Water Supply system will be studied: water intake on Jadro spring, route and elements of the aqueduct (channel, bridges and tunnels), water distribution tanks, lead pipe network and water appliances together with water quantity and quality issues. The study of sewage will consider wastewater and storm water drainage, as well as the protection from external surface water and groundwater. Besides those, methods, materials and techniques used by Roman engineers to establish efficient urban Water System indispensable for the life and health of the citizens will be analyzed and compared with modern system. The study will be based on collecting all data regarding explored elements of the Water System and on new archaeological excavations financed by this project. Existing topographic and architectonic surveys will be summarized and supplemented by new ones which will enable reconstruction of the whole system and elements. The project team is multidisciplinary and gathers civil engineers, architects and archaeologist. Apart from new knowledge about the planning, building and maintaining Roman Water Systems this project will give necessary data to protect elements of the system form devastation, to make a proper presentation and even to put some elements is use. ]]></summary_en></project><project>
<id>2210</id><title_hr><![CDATA[Održivi optički komunikacijski i senzorski sustavi zasnovani na rezonatoru s produženom rezonantnom šupljinom]]></title_hr><title_en><![CDATA[Sustainable Optical Communication and Sensor Systems based on Extended-Cavity Resonators]]></title_en><user_id>6686</user_id><user_firstLast_name>Zvonimir Šipuš</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-3425</code><acronim><![CDATA[EXCAR]]></acronim><duration>01.09.2014 - 31.08.2018</duration><status>Završio</status><financ_value>118.707,28 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>7148, 7044, 6893, 6886, 6949, 19032, 20069, </team_members_id><team_members_names><![CDATA[Dubravko Babic, Borivoj Modlic, Marko Bosiljevac, Dario Bojanjac, Damir Muha, Marko Šprem, Josip Lončar, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[optical access networks, WDM-PON, optical sensors, colorless optical transmitter, extended cavity, optical noise, noise reduction, wavelength re-use]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The objective of this project is to advance the state-of-the-art in optical access networks and also apply the same ideas to sensor networks. Proposed project addresses the EU targets as defined by European Commission’s “Europe 2020” strategy for smart growth by focusing on research and development of highly-integrated and energy efficient optical transceivers and wavelength-division-multiplexing (WDM) components for next-generation of access and mobile backhaul networks using passive optical network (PON) infrastructure. The primary challenge, in wider adoption of WDM-PON, lies in the development of sufficiently low cost technology to be used at the users’ premises. Self-seeded WDM-PON has been actively investigated in recent years as potentially the lowest cost solution for next-generation access networks. The primary attraction of this architecture is its simplicity, lower power consumption, and cost advantage. Similar principles can be applied to multiplexing and interrogation systems for optical sensors and our aim is to develop, analyze and demonstrate sustainable all-optical infrastructure based on extended cavity resonators able to provide physical layer for both, access communication and sensor networks.At University of Zagreb we invented an optical component, the modulation-averaging reflector, which reduces the penalty due to modulation of the seeding light and depolarizes the light oscillating in the cavity thereby stabilizing the extended resonator. This was the first step towards a future-proof optical access technology. Within this project we will fully develop and characterize systems based on extended cavity resonators with modulation averaging reflectors. We will also explore the use of modulation averaging concept in a novel communication optical source architecture based on wavelength re-use. Finally, the concept of extended cavity resonators will also be implemented in non-communication applications such as new optical sensor schemes.]]></summary_en></project><project>
<id>2213</id><title_hr><![CDATA[Gravitacija i narušenje pariteta]]></title_hr><title_en><![CDATA[Gravity and parity violation]]></title_en><user_id>3313</user_id><user_firstLast_name>Maro Cvitan</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2013-11</proposal_call><code>UIP-2013-11-8946</code><acronim><![CDATA[GRAPARION]]></acronim><duration>01.09.2014 - 22.02.2018</duration><status>Završio</status><financ_value>90.640,14 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>3371, 3433, 3399, 3418, 17858, 20367, 21426, </team_members_id><team_members_names><![CDATA[Ivica Smolić, Predrag Dominis Prester, Silvio Pallua, Loriano Bonora, Tamara Štemberga, Stefano Gregorio Giaccari, Mateo Paulišić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[gravity, black holes, parity violation, quantum anomalies, holography, string theory, conformal symmetry, entanglement entropy]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The effect of parity or charge-parity (CP) violation in gravitational theories has not been extensively studied so far in the literature. Nevertheless this phenomenon might be very important and help explaining the baryon asymmetry of the Universe: our Universe consists of matter, with the negligible amount of antimatter. Despite many attempts a satisfactory explanation for this asymmetry is not yet at hand, although it is generally accepted that the processes responsible for it must violate CP. The qualifying aim of this project is to explore the idea that CP violation may be traced back to gravity. However we believe it is more effective to cope with this problem in the framework of a more general research on parity violating effects in gravity, which we will study by means of modern methods of exploring the gravitational interaction: holography, Kerr black hole horizon-conformal field theory (Kerr-CFT) correspondence, trace anomalies, entanglement entropy, fluid-gravity correspondence. The focus will be in particular on the natural candidates for parity violating gravity processes - the Chern-Simons terms, both pure gravitational and mixed gauge-gravitational ones - using extra-dimension models inspired by the string theory. The expected outcome is a significant increase in understanding the consequences of parity violating gravitational interactions, not only in relation with possible CP violations, but also for other effects, e.g. for corrections to black hole entropy.]]></summary_en></project><project>
<id>2215</id><title_hr><![CDATA[Panorama hrvatske književnosti u Dubrovniku 17. stoljeća]]></title_hr><title_en><![CDATA[A Panorama of Croatian Literature in 17th Century Dubrovnik]]></title_en><user_id>2947</user_id><user_firstLast_name>Milovan Tatarin</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-8110</code><acronim><![CDATA[Panorama]]></acronim><duration>01.08.2014 - 31.07.2018</duration><status>Prekinut</status><financ_value>15.198,70 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filologija, </scie_field_hr><scie_field_en>Philology, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Croatian Literature, Dubrovnik, 17th Century, Critical edition, Tekstology]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Assuming that only the availability of all the works written in the 17th century will allow for a valid interpretation, both of individual oeuvres and of the period as a whole, I decided to use the manuscripts (not the existing printed editions) to prepare for publication the works of all the writers that were active from the end of 16th century until 1637 (death of Injacije Đurđević). We are talking about 42 poets. This project is thus a survey of everything that was written in the 17th century, in all three literary forms (Lyric, Narrative and Drama), excluding the writers that already have their own critical editions (Palmotić, Gleđević, Gundulić, Đurđević, Bunić). The project is substantial since it encompasses: a) collecting and comparison of manuscripts; b) transcribing the manuscripts; c) an accompanying study. This project is neither an anthology nor a chrestomathy, but it strives to collect in one place everything that a certain writer wrote, regardless of the literary value.]]></summary_en></project><project>
<id>2216</id><title_hr><![CDATA[Preobrazba građanskog pravosuđa pod utjecajem globalnih i regionalnih integracijskih procesa. Jedinstvo i različitost]]></title_hr><title_en><![CDATA[Transformation of Civil Justice under the Influence of Global and Regional Integration Processes. Unity and Diversity]]></title_en><user_id>3028</user_id><user_firstLast_name>Alan  Uzelac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-6988</code><acronim><![CDATA[TCJust-UD]]></acronim><duration>01.01.2015 - 31.12.2018</duration><status>Završio</status><financ_value>74.316,10 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Pravo, </scie_field_hr><scie_field_en>Law, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Pravni fakultet u Zagrebu]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Law]]></institution_en><team_members_id>4219, 3969, 4405, 3341, 5320, 5043, 5032, 3428, 5783, 3062, 5042, 17777, </team_members_id><team_members_names><![CDATA[Cornelis Hendrik van Rhee, Elisabetta Silvestri, Aleš Galič, Aleksandra  Maganić, Marko Petrak, Ivan Milotić, Tomislav Karlović, Slađana Aras, Barbara Preložnjak, Marko Bratković, Henrik-Riko Held, Juraj Brozović, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[civil justice, civil procedure, harmonisation, unification, globalization, integration, ius commune, effective legal protection, legal history]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[National civil justice systems are deeply rooted in national legal culture and traditions. However, in the past few decades they are increasingly under the influence of integration processes at the supra-national, regional and international level. The emergence of economic and political unions and globalisation processes exert as a by-product pressure to harmonise or even unify the way in which national civil justice systems operate. In an attempt to create a ‘genuine area of justice’, new unified procedures are being developed. They operate in parallel with national civil procedures, and sometimes even strive to replace them. As a reaction to the forces that endeavour to harmonise and unify procedural laws and practices, an opposite trend is gaining momentum: a trend that insists on diversity and pluralism of national civil procedures. The basis of this trend is the claim for national procedural autonomy/sovereignty. The research within this project will focus on the evolution of procedural reforms in various jurisdictions, with a particular emphasis on Croatia, its broader region (successor states of the former Yugoslavia) and Europe. The purpose is to identify to what extent the tensions between the centrifugal and centripetal forces contribute to development of judicial structures that provide a higher level of proper and effective legal protection, and to which extent these tensions create confusion and produce legal transplants and irritants that are equally or less effective than traditional procedures.]]></summary_en></project><project>
<id>2224</id><title_hr><![CDATA[Fleksibilna energetska čvorišta u nisko ugljičnim naprednim elektroenergetskim mrežama]]></title_hr><title_en><![CDATA[Flexible energy nodes in low carbon smart grid]]></title_en><user_id>6497</user_id><user_firstLast_name>Igor Kuzle</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-7766</code><acronim><![CDATA[FENISG]]></acronim><duration>01.10.2014 - 30.09.2018</duration><status>Završio</status><financ_value>128.528,77 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>6990, 6996, 7087, 7162, 7186, 7211, 7278, 7348, 7160, 7194, 19028, 22939, </team_members_id><team_members_names><![CDATA[Zeljko Tomsic, Marko Delimar, Davor Škrlec, Hrvoje Pandžić, Ninoslav Holjevac, Miljenko Brezovec, Tomislav Plavšić, Juraj Havelka, Sejid Tešnjak, Matija Zidar, Kristina Jurković, Stjepan Tusun, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[energy/power nodes, smart grids, reneawable energy sources, distributed generation, energy storage, plug in electrical vehicles]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The share of renewable energy sources (RES) in electric power systems (EPS) has increased during the recent years and this trend is expected to continue. The stochastic nature of electricity production from RES imposes new challenges for the EPS operation and control. A large share of undispatchable RES can lead to significant disturbances of EPS components. These disturbances need to be balanced out and the security of the system has to be preserved. If the resources for providing balancing energy and flexibility are limited, secure operation of the EPS will become highly expensive. Conventional generation units provide the necessary flexibility to maintain a continuous balance between supply and demand. The question is: are these conventional resources the most feasible way of providing system flexibility in the future low carbon systems? During the recent years, plug-in hybrid electric vehicles (PHEV) have become an attractive way of transportation. While passive approach to their integration might cause problems to the system, active utilization of their flexibility might enable higher penetration of RES. A similar reasoning can be applied to the distributed generation, especially technologies with the potential of multi energy vector interaction (efficient electric heating, combined heat and power, battery storage etc.).Current grids need to be capable of dealing with mentioned requirements. The concept of Smart Grid (SG) is based on using of novel information and communication technology (ICT) and includes application of a spectrum of innovative and flexible technologies.The purpose of this project is to establish a methodological and comprehensive framework providing the costs and benefits evaluation of SG projects and technologies. Given the sizeable investments needed, there is a need for a fair, consistent and methodological approach for estimation of the best investment option, taking into account economic and environmental aspects of a specific project.]]></summary_en></project><project>
<id>2225</id><title_hr><![CDATA[Teoretsko i primjenjeno jezikoslovno istraživanje korpusa hrvatskih crkvenoslavenskih tekstova s izradom Rječnika crkvenoslavenskoga jezika hrvatske redakcije]]></title_hr><title_en><![CDATA[Theoretical and applied linguistic research of the corpus of the Croatian Church Slavonic texts with the Dictionary of the Croatian Redaction of Church Slavonic compiling ]]></title_en><user_id>1047</user_id><user_firstLast_name>Vida Vukoja</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2013-11</proposal_call><code>UIP-2013-11-2462</code><acronim><![CDATA[TALRCCCSTDCRCSC]]></acronim><duration>01.07.2014 - 30.06.2018</duration><status>Završio</status><financ_value>48.041,41 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filologija, </scie_field_hr><scie_field_en>Philology, </scie_field_en><institution_hr><![CDATA[Staroslavenski institut]]></institution_hr><institution_en><![CDATA[Old Church Slavonic Institute in Zagreb]]></institution_en><team_members_id>1119, 2569, 4724, 6597, 6756, 7397, </team_members_id><team_members_names><![CDATA[Jozo Vela, Lucija Turkalj, Zdenka Ribarova, Anica Nazor, Ana Kovačević, Marija Klenovar, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Croatian Church Slavonic, (paleo)slavistic studies, (historical) lexicography, Medieval studies, linguistics ]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Croatian Church Slavonic (CCS) is a bookish language system written in Glagolitic script, with the preserved documents originated from the XI/XII to the XVII c., developed on the basis of the Old Church Slavonic (OCS; created by Sst. Cyrill and Methodius), and under heavy influence of the medieval Croatian vernacular. Being referential and representative, the corpus of the CCS texts provides the most effective basis available for the relevant research of the CCS.The project includes theoretical and applied linguistic research. Among the applied linguistic disciplines, two lexicographic tasks play focal roles: compiling of Rječnik crkvenoslavenskoga jezika hrvatske redakcije (Eng. Dictionary of the Croatian Redaction of Church Slavonic; DCRCS) and conversion of the CCS corpus into digitally readable text(s). Theoretical and other, non-lexicographical, applied linguistic research include those within the fields of: semantics (esp. of the lexis expressing feelings/passions), theory and practice of (medieval) translation (direct translation from Latin into CCS, and inherited OCS translations of the Greek texts within the CCS tradition), grammar (primarily syntax of negation, agreement, infinitive, CCS psalter), textology (selected CCS texts, CCS psalter).	Substantial contribution of the project research cover (inter)national fields of: (paleo)slavistic and medieval studies, historical lexicography, diachronic study of the Croatian language diasystem, interdisciplinary investigation of the history of emotions. Finally, through the CCS corpus management (i.e. conversion of the CCS corpus into digitally readable format) and the DCRCS compiling, the project offers irreplaceable and permanent assistance to any scholarly or scientific field interested in the CCS texts contents. Due to the range of texts incorporated into the corpus, this contribution is virtually unforseeable.]]></summary_en></project><project>
<id>2230</id><title_hr><![CDATA[MAtematička analiza multifizikalnih problema koji uključuju tanke i kompozitne strukture i fluide]]></title_hr><title_en><![CDATA[Mathematical Analysis of Multiphysics problems Involving Thin and Composite Structures and Fluids]]></title_en><user_id>6764</user_id><user_firstLast_name>Igor  Velčić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2013-11</proposal_call><code>UIP-2013-11-9477</code><acronim><![CDATA[MAMPITCoStruFl]]></acronim><duration>01.09.2014 - 31.08.2017</duration><status>Završio</status><financ_value>103.935,28 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>7180, 5074, 5872, 6840, 4816, 17761, 20370, </team_members_id><team_members_names><![CDATA[Suncica Canic, Boris Muha, Mario Bukal, Maroje Marohnić, Josip Tambača, Marija Galić, Marin Bužančić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[thin structures, composite structures, dimensional reduction, homogenization, Gamma convergence, fluid-structure interaction, existence of solution ]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Composite materials are materials made from two or more constituent materials with different physical properties that, when combined, produce a material with characteristics different from those of its individual components. Thin and composite structures are of extreme importance for applications in engineering (e.g. building blocks, boats, ships, aircraft design) and biology (bones, biological tissues, blood vessels) where they are often subjected to fluid load. The analysis of these kind of complex multi-physics systems is very challenging from the mathematical point of view. Namely, the analysis of thin and composite structures and fluids includes the analysis of nonlinear partial differential equations (nonlinear PDEs), which leads to interesting mathematical questions (Gamma limits of a certain system of nonlinear equations with highly oscillating coefficients, existence for a certain system of nonlinear PDEs). This project plans the following: derivation of lower dimensional models in elasticity for highly oscillating materials, optimal design problems, derivation and analysis of fluid-structure interaction problems (derivation of coupling conditions, well-posedness and asymptotic stability analysis). We will use both Calculus of Variation and PDEs techniques to approach different topics, using the benefits from both. We strongly believe that this diversity will bring additional value to Croatian applied mathematics and will provide young people to develop and get acquainted with different approaches of the modern applied mathematics.]]></summary_en></project><project>
<id>2232</id><title_hr><![CDATA[Razvoj konkurentnosti hrvatskog prerađivačkog sektora]]></title_hr><title_en><![CDATA[Building competitiveness of Croatian manufacturing]]></title_en><user_id>653</user_id><user_firstLast_name>Jasna Prester</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-3535</code><acronim><![CDATA[EMS_GMRG]]></acronim><duration>01.07.2014 - 30.06.2018</duration><status>Završio</status><financ_value>44.921,24 eur</financ_value><scie_area_hr>Društvene znanosti, Tehničke znanosti, </scie_area_hr><scie_area_en>Social sciences, Technological sciences, </scie_area_en><scie_field_hr>Ekonomija, </scie_field_hr><scie_field_en>Economy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Ekonomski fakultet u Zagrebu]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Economics and Business]]></institution_en><team_members_id>293, 2584, 4422, 4455, 2519, 5210, </team_members_id><team_members_names><![CDATA[Božidar Matijević, Najla  Podrug, IVANA RAŠIĆ BAKARIĆ, Davor Filipović, Maja Daraboš, Ivan Kumić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Manufacturing, manufacturing practices, technology, organizational innovations, EMS, GMRG, Croatia]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[There are several trends in global manufacturing. Higher automatization reduces the need for human labour and China manufacturing is posing a considerable threat. Manufacturing companies in developed countries are seeking ways to stay competitive on the global market since a considerable part of their GDP is acquired by manufacturing, but unfortunately, shrinking. At the moment there are two large scale projects exploring manufacturing sector: EMS and GMRG Survey. Both surveys look at different aspects of manufacturing and engage different countries. EMS covers 18, while GMRG survey includes 24 countries including China, Taiwan and others. The main objective for application is to enable Croatian scientist to be equal partners in such large scale projects and access data from other countries and carry out comparative analyses that will benefit the researchers and manufacturing industry in Croatia. It must be emphasized that Faculty of Business and Economics is the partner for both EMS and GMRG project for number of years but never had the chance to exploit the privileges.   Both surveys explore in detail manufacturing so willingness of the industry to participate is essential. In order to do that, Faculty of Business and Economics will have to provide several workshops on which participants will see the comparative results between countries and be motivated to participate in the next round. All the acquired knowledge will be shared with industry experts and all the results will be available on the internet page of the host Institution. The project is interdisciplinary because it investigates the manufacturing technology and processes, as well as the usage of novel materials. Therefore colleagues from Engineering Sciences are participating in the project since the latest results in manufacturing research shows that advanced technology and advanced materials are the only source left for sustaining the competitive advantage in comparison to China.]]></summary_en></project><project>
<id>2246</id><title_hr><![CDATA[Nanominerali u sedimentima i tlima: formiranje, značajke i uloga u biogeokemijskim procesima]]></title_hr><title_en><![CDATA[Nanominerals in sediments and soils: formation, properties and the role in biogeochemical processes.]]></title_en><user_id>6786</user_id><user_firstLast_name>Ivan Sondi</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-2504</code><acronim><![CDATA[NanoMin]]></acronim><duration>01.09.2014 - 30.09.2018</duration><status>Završio</status><financ_value>124.111,18 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Geologija, </scie_field_hr><scie_field_en>Geology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Rudarsko-geološko-naftni fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mining, Geology and Petroleum Engineering]]></institution_en><team_members_id>2669, 4675, 6573, 2885, 2920, 624, 6464, 3252, 614, 4415, 3030, 6023, 20538, </team_members_id><team_members_names><![CDATA[Goran Durn, Sonja Lojen, Mladen  Juračić, Sibila Borojević Šoštarić, Marta Mileusnić, Neda Vdović, Srečo Davor Škapin, Uroš Barudžija, Irena Jurina Tokić, Maja Ivanić, Stanko Ružičić, Igor Felja, Tomislav Brenko, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[geochemistry, nanoparticles, nanominerals, sediments, soils ]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The Project aims to investigate mineralogical, morphological, geochemical and surface physico-chemical properties of the naturally occurring inorganic nanomineral fraction separated from different modern marine and lacustrine sediments and soils developed on carbonate rocks along the Adriatic coast. The unique structural, chemical and surface properties of nanomineral phases and their role in cycling of trace elements in modern sediments and soils will be determined. The primary objectives of this project are: (1) to identify the size, the unique mineralogical, morphological, geochemical and surface physico-chemical properties of the naturally occurring inorganic nanomineral fractions; (2) to determine the early diagenetically driven formation and phase transformation of nanosized carbonate, sulfide and iron (hydr)oxide particles in modern lacustrine and marine sediments at the nanoscale; (3) to resolve pedogenetically driven formation of nanosized clay mineral and iron and manganese (hydr)oxide particles in soils at the nanoscale. Specifically, the role of iron (hydr)oxides, and humic materials on nanoscale agglomeration processes in soils will be also evaluated; (4) to determine the carbonate equilibrium, the origin of bulk and molecularly uncharacterized sedimentary organic matter, as well as dissolved inorganic matter in the sediments, soils and interstitial water using stable isotopes (13C/12C and 15N/14N) as natural tracers. Sources of DIC (carbonate dissolution vs. decomposition of sedimentary organic matter) in the pore water and in the DIC flux across the sediment – water interface, as well as in the sedimentary carbonate fraction will be appointed, so as to estimate the contribution of organically derived CO2 to the formation of authigenic nanocarbonate solids; and (5) to introduce and incorporate findings from “NanoMin” into the Croatian geosciences domain.]]></summary_en></project><project>
<id>2247</id><title_hr><![CDATA[Inženjering kristalnih materijala pomoću metalnih kompleksa i nekovalentnih interakcija]]></title_hr><title_en><![CDATA[Engineering crystalline materials using metal complexes and non-covalent interactions]]></title_en><user_id>1229</user_id><user_firstLast_name>Marijana Đaković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2013-11</proposal_call><code>UIP-2013-11-1809</code><acronim><![CDATA[CRYSTIN]]></acronim><duration>01.09.2014 - 20.11.2017</duration><status>Završio</status><financ_value>91.939,15 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>713, 2648, 1327, 4669, 3881, 17739, </team_members_id><team_members_names><![CDATA[Željka Soldin, Aleksandar Višnjevac, Boris-Marko Kukovec, Ivan Kodrin, Christer Aakeroy, Mladen Borovina, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[crystal engineering, non-covalent interactions, supramolecular architecture, synthons, metal complexes]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Interdisciplinary research at the interface of chemistry and materials science has been remarkably successful at producing technologies that have revolutionized all aspects of everyday life.  However, there is still a great need for new solids with ‘improved’ physical properties (faster, cheaper, smarter or more responsive than current alternatives). Unfortunately, the ability to ‘dial-in’ a property or physical response remains a major challenge. Therefore, our goal is to establish reliable avenues for the design of crystalline metal-containing materials by encoding building-blocks with structural-preferences that lead to ‘programmable’ assembly, thus avoiding serendipity and chance when targeting new materials with specific and tunable properties. To achieve this, we first need to map out the structural landscape that controls how metal complexes communicate and subsequently assemble into 3-D architectures.We will explore and quantify the interrelationship between ligand-field splitting energy, coordination geometry, metal-ligand dimensionality, ligand flexibility, and supramolecular assembly, one variable at a time, using a combination of experiment and theory.  This will enable us to map out the structural landscape defined by metal(II) complexes (Co, Ni, Cu and Cd) and custom-made ligands decorated with functionalities that are known to form reliable supramolecular synthons in organic solids.New structural and spectroscopic information will be complemented by data obtained by mining the CSD, while computational methods will inform both the planning as well as the interpretation of the experimental efforts. The results obtained in this systematic and multidisciplinary research program will create new avenues towards the design of crystalline metal-containing materials based on reliable structure-activity protocols.]]></summary_en></project><project>
<id>2249</id><title_hr><![CDATA[Razvoj paketa računalskih programa za naprednu analizu štitova od gama i neutronskog zračenja]]></title_hr><title_en><![CDATA[Development of Code Package for Advanced Gamma and Neutron Shielding Analysis]]></title_en><user_id>6070</user_id><user_firstLast_name>Krešimir Trontl</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2013-11</proposal_call><code>UIP-2013-11-3522</code><acronim><![CDATA[DOCPAGANSA]]></acronim><duration>21.07.2014 - 20.10.2017</duration><status>Prekinut</status><financ_value>53.487,29 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>7255, 6980, 6827, 17764, </team_members_id><team_members_names><![CDATA[Dubravko Pevec, Radomir Ječmenica, Mario Matijević, Paulina Dučkić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[machine learning, active learning, parallel and distributed computing, gamma shielding, neutron shielding]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Radiological safety analysis is equally important in all fields of peaceful application of nuclear energy, like industry or medicine, as well as for adequate radioactive waste management. In general, shielding analyses can be classified into two categories: preliminary analyses and final analyses. Preliminary analysis can be conducted using computer codes based on engineering methods, the most used one based on point-kernel method. Recent research indicated that a new approach can be used in determination of buildup factors as the key parameters of point-kernel method. The approach is based on machine learning technique, namely Support Vector Regression (SVR). For efficient training of the SVR models of a complex physical problem, an active learning procedure has to be defined. Final shielding analysis is usually conducted by computer codes based on either deterministic or statistic methods placing high time and hardware demands, but resulting in more accurate results. Advanced numerical procedures utilize advantages of both, deterministic approach as well as stochastic approach resulting in a hybrid deterministic-stochastic procedure increasing the efficiency of the overall analysis.The overall objective of the proposed project is the development of the synthesized calculational tool to enable all stages of a shield design to be performed within integrated environment. To accomplish this objective following activities are planned: definition of the optimal active learning procedure in regression framework to prepare data sets for SVR model creation, investigation of gamma and neutron buildup factors and preparation of SVR models, development of the computational tool for preliminary stage shielding design, optimization of hybrid deterministic-stochastic numerical procedure, development of the control module for automatic shielding analyses process control, preparation of front-end and back-end interface, testing of the final shielding analysis environment. ]]></summary_en></project><project>
<id>2255</id><title_hr><![CDATA[Biofizikalni dizajn antimikrobnih peptida i inovativni molekularni deskriptori]]></title_hr><title_en><![CDATA[Biophysical Design of Antimicrobial peptides and Innovative Molecular Descriptors]]></title_en><user_id>5542</user_id><user_firstLast_name>Damir Vukičević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-8481</code><acronim><![CDATA[BioAmpMode]]></acronim><duration>15.09.2014 - 14.12.2017</duration><status>Završio</status><financ_value>50.800,20 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Science]]></institution_en><team_members_id>3581, 3589, 3599, 87, 4882, 5478, 5373, 5545, 5636, 6123, 6627, 6630, 6633, 6683, 5731, 18995, 17844, 586, 3580, </team_members_id><team_members_names><![CDATA[Juraj Simunić, Nada Ilić, Mario Novkovic, Goran Gajski, Frances Separovic, Alessandro Tossi, Anita Kriško, Jelena Sedlar, Tomislav Došlić, Marija Raguž, Nataša  Vučemilović-Alagić, Mara Kozić, Lara Romac, Lucija Krce, Ana Maravić, Luka Gujinović, Tomislav Rončević, Ivana Goić Barišić, Davor Juretic, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Antimicrobial peptides, Molecular descriptors, Therapeutic index, Drug development, Design, Data-mining, Antibiotics, Multidrug resistance]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The starting point of this interdisciplinary project is bioinformatic and chemoinformatic data collection connecting molecular structure with physico-chemical and biological properties. In the case of antimicrobial peptides, measured biological activity and therapeutic index data will be collected from published papers with the goal of constructing robust and accurate predictive models. A large amount of data regarding the 20 natural amino acids attributes will also be collected and analysed. We plan to propose new scales of amino-acid attributes that may be a basis for a multitude of future studies. In our experience, construction of good predictive models is not possible without using biophysical insights to propose appropriate molecular descriptors crucial for data-mining procedure and model building. These models should be based on newly developed molecular descriptors. Study of molecular descriptors will be important part of this project, their extremal properties (as indicators of the most active compounds), their complexity of calculation (since exhaustive search for optimal compounds can be computationally demanding) and their interrelationships. Dedicated algorithms for in-silico identification or proposal of structures with the desired properties will be built and verified through synthesis, characterization and testing of predicted antimicrobials. The activity, selectivity, conformation and mechanism of action of lead compounds will be explored using biophysical, biochemical and microbiological techniques. Preliminary investigations by our group of graduate, doctoral and postdoctoral biophysics students has already led to the identification of two designed peptides as being very active against pan-resistant Acetinobacter baumanni, so that initial drug development is within the scope of this project with the aim of finding new classes of non-toxic peptide antibiotics active against multidrug resistant bacteria.]]></summary_en></project><project>
<id>2258</id><title_hr><![CDATA[Karakterizacija reakcije osteoklastnih progenitora na artritis]]></title_hr><title_en><![CDATA[Characterization of osteoclast progenitor responses to arthritis]]></title_en><user_id>3075</user_id><user_firstLast_name>Danka Grčević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-5699</code><acronim><![CDATA[COPERA]]></acronim><duration>01.09.2014 - 31.08.2017</duration><status>Završio</status><financ_value>92.817,94 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>3895, 4356, 2978, 3882, 3832, 3604, 5107, 5106, 5878, 5110, 5860, 17836, </team_members_id><team_members_names><![CDATA[Alan Šućur, Frane Paić, Vedran Katavić, Nataša Kovačić, Elvira Lazić Mosler, Marina Ikić Matijašević, Zrinka Jajić, Asja Stipić Marković, Peter Ian Croucher, Ivo Kalajzić, Hector Leonardo Aguila, Darja Flegar, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[osteoclasts, arthritis, inflammation, progenitors, differentiation, cytokines, chemokines]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Chronic joint diseases affect more than a third of the world’s population and represent a major health problem. Several forms are classified in clinical practice, depending on the main pathogenic mechanism: osteoarthritis, rheumatoid arthritis (RA) and spondyloarthritis Collagen-induced arthritis (CIA) is a widely used mouse model of RA and is still an indispensible tool to study the disease pathogenesis. Through the production of osteoresorptive mediators by immune cells, chronic inflammation in arthritis creates a microenvironment that promotes osteoresorption by osteoclasts (OC). OCs are multinucleated bone-resorbing cells arising from myeloid hematopoietic lineage. A number of systemic and local stimuli, such as hormones and cytokines/chemokines, promote osteoclastogenesis by enhancing OC differentiation, migration, activation, lifespan and function, but the exact mechanisms of how the inflammatory network works in vivo in the context of arthritis are largely unclear. Particularly, the human osteoclast progenitor (OCP) populations are not precisely defined and it is, as yet, unknown which critical mediators have the potential to activate OCPs and attract them to produce joint lesions. Using the mouse model of CIA and samples from arthritic patients we propose to elucidate differentiation sequence of early progenitors into mature OCs, shifts in the frequency of discrete OCP subpopulations and their migration patterns during arthritis. We plan to identify distinct OCP subpopulations in the bone marrow, periphery and joint lesions, their migratory and homing patterns, and their functional links to bone loss in arthritis. We expect to define the properties of inflammatory microenvironment in the regulation of OC trafficking, differentiation and activity in arthritis. A better characterization of arthritis-induced OCP subpopulations could offer the potential to design therapeutic approaches to control their migration and curtail their osteoresorptive potential.]]></summary_en></project><project>
<id>2259</id><title_hr><![CDATA[Molekularni mehanizmi imunološkog djelovanja PVR(CD155) u virusnoj i tumorskoj patogenezi]]></title_hr><title_en><![CDATA[Molecular mechanisms of PVR(CD155) immunological pathways in viral and tumor pathogenesis]]></title_en><user_id>4941</user_id><user_firstLast_name>Tihana Lenac Roviš</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2013-11</proposal_call><code>UIP-2013-11-1533</code><acronim><![CDATA[PVRreg]]></acronim><duration>31.10.2014 - 30.04.2018</duration><status>Završio</status><financ_value>131.726,72 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo, Prirodne znanosti, </scie_area_hr><scie_area_en>Biomedicine and health sciences, Natural sciences, </scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Medicine]]></institution_en><team_members_id>5361, 5312, 5204, 22539, </team_members_id><team_members_names><![CDATA[Hrvoje Šimić, Antonija Miletić, Paola Kučan, Ivana Stražić Geljić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[poliovirus receptor, PVR, CD155, cytomegalovirus, CMV, immunoevasion, tumor]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The project is focused on the role of PVR (poliovirus receptor) which serves as a ligand for both inhibitory (TIGIT) and activating (DNAM-1 and Tactile) receptors. The evidence has been accumulated indicating the role of PVR and its receptors in immune surveillance including the control of viral infections, tumors, as well as in pathogenesis of autoimmune diseases. Of note is that PVR is constitutively expressed on the majority of somatic cells, while its receptors are expressed on the majority of lymphocyte population. In many respects the interaction of PVR with its paired set of inhibitory and activating receptors resemble the interaction of paired co-stimulatory immune cell receptors and their cellular ligands (B7/CD28/CTLA-4). These co-stimulatory molecules have been the subject of intensive studies that resulted in immunoregulatory pharmaceutical agents for use in humans. The studies proposed here are based on the finding that human cytomegalovirus (HCMV) affects the surface expression of PVR (Nat Immunol. 2005) and on our preliminary results indicating that mouse cytomegalovirus (MCMV) also downregulates mouse PVR. Thus, we first focused on the identification of MCMV gene(s) (proteins) involved in the PVR regulation, but also on the consequence of this viral regulation on antiviral immune response in vivo. To that aim we will generate MCMV mutants lacking viral regulators and test their in vivo susceptibility to components of innate and acquired immune response. We expect that the results obtained will further broaden the knowledge of PVR regulation and its significance in immune control, which will eventually help to translate this knowledge to developing new immunotherapeutic tools. Namely, one aim of this project is to engineer antibody specific for human PVR in order to be used as a tool in targeted tumor therapy. This idea is based on the fact that many tumors over-express PVR, which could be used in antibody mediated uptake of anti-tumor compounds. ]]></summary_en></project><project>
<id>2260</id><title_hr><![CDATA[Moderne i suvremene umjetničke mreže, umjetničke grupe i udruženja: Organizacijski i komunikacijski modeli suradničkih umjetničkih praksi 20. i 21. stoljeća]]></title_hr><title_en><![CDATA[Modern and Contemporary Artist Networks, Art Groups and Art Associations: Organisation and Communication Models of Artist Collaborative Practices in the 20th and 21st Century]]></title_en><user_id>6142</user_id><user_firstLast_name>Ljiljana Kolešnik</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-6270</code><acronim><![CDATA[ARTNET]]></acronim><duration>01.09.2014 - 10.12.2018</duration><status>Završio</status><financ_value>71.311,70 eur</financ_value><scie_area_hr>Humanističke znanosti, Društvene znanosti, Tehničke znanosti, </scie_area_hr><scie_area_en>Humanities, Social sciences, Technological sciences, </scie_area_en><scie_field_hr>Povijest umjetnosti, </scie_field_hr><scie_field_en>Art history, </scie_field_en><institution_hr><![CDATA[Institut za povijest umjetnosti]]></institution_hr><institution_en><![CDATA[Institute of Art History, Zagreb]]></institution_en><team_members_id>2535, 6333, 5489, 4944, 4649, 6030, 4910, 21394, 17659, 23291, </team_members_id><team_members_names><![CDATA[Petar Prelog, Sanja ¸Horvatinčić, Dalibor Prančević, Željka Tonković, Tamara  Bjažić Klarin, Ivana Meštrov, Irena Kraševac, Sanja Sekelj, Nikola Bojić, Artur Šilić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[history of art, methodology, artist networks, art groups, social networks, data visualization, Croatian modern art, Croatian contemporary art]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Research topics of this project are the organization and communication models embedded into artist networking and artist collaborative practices of the 20th and 21st century, as they are manifested in the Croatian art of that period. Project initial hypothesis is that artist networks, art groups and art associations form the most important platform of cultural exchange in modern and contemporary visual arts due to the similarity of underlying organization and communication models regardless of geo-cultural location at which they appear. A degree of their diversity in art practice of particular local community at particular historical moment is proportional to the dynamics and volume of its participation in the international/cross-cultural exchange. To prove our hypothesis and identify, describe and explain these organization and communication models as generally applicable – which is the main objective of the project - we shall investigate Croatian artist networking and collaborative practices on the background of similar phenomena in other European countries and with regard to poetic requirements of different periods in modern and contemporary art, conventions of social interactions and available techniques/technologies of communication. As the methodology of art history does not meet the complexity of the research topic, we shall develop interdisciplinary methodological apparatus combining knowledge and analytic tools of art history, sociology and information science. Considerable amount of data collected through the extensive infield research will be stored in Croatian Artists Networks Information System developed in the course of the project and supporting network visualization techniques as a cognitive research tool for experimental presentation of our research results framed with the appropriate structural narratives (textual, visual, GIS data). Project results will be also presented in 2 books, 7 articles and at the closing international conference.]]></summary_en></project><project>
<id>2264</id><title_hr><![CDATA[Nastavničke emocije i strategije emocionalne regulacije: osobni i kontekstualni antecedenti i efekti na motivaciju, dobrobit i odnose sa studentima]]></title_hr><title_en><![CDATA[Teachers’ emotions and emotion regulation strategies: personal and contextual antecedents and effects on motivation, well-being and relationships with students]]></title_en><user_id>6118</user_id><user_firstLast_name>Irena Burić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2013-11</proposal_call><code>UIP-2013-11-5065</code><acronim><![CDATA[TEERS-ZD5]]></acronim><duration>01.09.2014 - 31.08.2017</duration><status>Završio</status><financ_value>26.534,50 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Psihologija, </scie_field_hr><scie_field_en>Psychology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zadru]]></institution_hr><institution_en><![CDATA[University of Zadar]]></institution_en><team_members_id>6241, 5908, 6136, 6552, 21148, </team_members_id><team_members_names><![CDATA[Izabela Sorić, Zvjezdan Penezić, Ana Slišković, Ivana Macuka, Enrica Ciucci, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Teachers, emotion, emotion regulation strategies, personal antecedents, contextual antecedents, motivation, well-being, relationship with students]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Although cognition, motivation and emotion are recognized by psychologists as the three fundamental classes of mental operations (Mayer, Salovey and Caruso, 2000), most research in educational psychology has primarily focused on the first two classes. This is especially true regarding teachers’ emotional lives. The existing knowledge on teachers’ emotions indicates their influential potential on instructional practices, professional and personality development and well-being. By implication, emotions experienced by teachers in classroom settings and in relation to their professional activities, arise as a very important topic of research. Thus the main goal of this research proposal is to investigate the phenomena of teachers’ emotions and emotion regulation strategies as well as their personal and contextual antecedents and effects on various aspects of personal and professional functioning. In order to achieve this goal, the multimethod approaches will be implemented.  More precisely, through the combination of qualitative and quantitative  methods, cross-sectional and longitudinal research designs, and individual and nomothetic approach, relations between teachers’ emotions and emotion regulation strategies, their personal (e.g. temperament, personality, beliefs, goals, cognitive appraisals) and contextual antecedents (factors from teachers’ school environment), as well as their effects on motivation (e.g. intrinsic vs. extrinsic motivation, goal orientations, self-efficacy), well-being (e.g. emotional labour, emotional exhaustion, burnout, mental health and intention to leave the profession) and relationships with students (e.g. different aspects of student-teacher interaction) will be explored on the samples of elementary-school teachers. ]]></summary_en></project><project>
<id>2267</id><title_hr><![CDATA[Profesionalni razvoj tijekom adolescencije: Razvoj i provjera Modela tranzicije karijere u adolescenciji]]></title_hr><title_en><![CDATA[Vocational Development in Adolescence: Setting the Adolescent Career Transition Model]]></title_en><user_id>1178</user_id><user_firstLast_name>Iva Šverko</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2013-11</proposal_call><code>UIP-2013-11-1229</code><acronim><![CDATA[VDAACTM]]></acronim><duration>01.07.2014 - 30.06.2017</duration><status>Završio</status><financ_value>38.945,46 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Psihologija, </scie_field_hr><scie_field_en>Psychology, </scie_field_en><institution_hr><![CDATA[Institut društvenih znanosti Ivo Pilar]]></institution_hr><institution_en><![CDATA[Institute of Social Sciences Ivo Pilar in Zagreb]]></institution_en><team_members_id>6293, 6545, </team_members_id><team_members_names><![CDATA[Toni Babarović, Vanja Međugorac, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[career transition, adolescence, career maturity, career identity, career decision making]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The aim of this project is to develop, postulate and evaluate an Adolescent Career Transition Model (ACTM). For most people the adolescence is the tipping point for career decision making. Last grade high-school students have to decide between further education on universities or entering the world of work and finding a job. To successfully overcome this important career transition period, adolescents have to become aware of their preferences and capabilities, to crystallize their career goals and to form their vocational identity. By implementing their vocational identity through engagement in their desired job or educational program, they should be able to achieve success and satisfactions in their careers, to fit in and adjust to their working environment and job demands, and to be motivated for their work and future advancement. The Adolescent Career Transition Model encompasses several career related behaviours, competences and traits that can influence positive career transition outcomes. We will assess approximately 1200 high school students at the beginning of the last grade of high-school (17-18 years) and follow their career development for the next 18 months. In three separate time points we will administer measures of career-related traits and social support, career self-guidance competencies, vocational development and career transition outcomes, through a secure online testing system that will be developed for this project. Statistical data analysis of the obtained data will be performed by adequate multivariate models to answer specific research objectives. Once the postulation and evaluation of the ACTM and the dissemination of the results are completed, the aim of the project is to create a new online career guidance system on the basis of the results of our research. This new online guidance system will be open and free for public use, and remain as a valuable and practically usefully legacy of the project.]]></summary_en></project><project>
<id>2273</id><title_hr><![CDATA[Sveobuhvatni model istraživanja zabrinutosti za privatnost u online okruženju]]></title_hr><title_en><![CDATA[Extended model of online privacy concern ]]></title_en><user_id>177</user_id><user_firstLast_name>Jelena Budak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-7913</code><acronim><![CDATA[PRICON]]></acronim><duration>01.07.2014 - 30.06.2018</duration><status>Završio</status><financ_value>66.070,32 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, </scie_field_hr><scie_field_en>Economy, </scie_field_en><institution_hr><![CDATA[Ekonomski institut Zagreb]]></institution_hr><institution_en><![CDATA[Institute of Economics in Zagreb]]></institution_en><team_members_id>189, 174, 3437, 674, 17736, </team_members_id><team_members_names><![CDATA[Ivan-Damir   Anić, Edo Rajh, Vatroslav Škare, Bruno Škrinjarić, Vedran Recher, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[online privacy concern, antecedents, internet, consumer protection, survey]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The research project will develop a comprehensive integrated model of privacy concern in the online environment and empirically test it in order to provide deeper understanding of various interactions between antecedents, concerns and consequences of online privacy. The research objectives will be achieved initially by identifying and developing (i) a comprehensive list of antecedents such as demographic factors (e.g. gender, education), experience factors (e.g. internet use experience, web expertise) and social-psychological factors (values, attitudes), and (ii) a comprehensive list of consequences of online privacy concern on individual-user level. These inputs will be used to develop an extended integrated model of online privacy concern in order to examine conceptual interrelations. Upon building a model, a customized survey questionnaire will be designed and measurement instruments for variables tested. The field research will consist of surveying 2,000 citizens in Croatia to assess their attitudes and behavior patterns when taking different roles and actions in the online environment. This core part of the research aims to empirically test the conceptualized model by employing adequate analytical tools to the large database collected in the survey. The research will result in the final definition of integrated theoretical framework of online privacy concern that will consolidate various streams of research in this field. The extended model of online privacy concern could be applied in future development in the related domain. The additional project outcomes are policy implications and recommendations for regulatory control, internet users policy and business strategies.]]></summary_en></project><project>
<id>2277</id><title_hr><![CDATA[Poluvodički elementi visokih performansi  za primjene u sklopovima za bežične komunikacije i optičke detektore]]></title_hr><title_en><![CDATA[High-performance Semiconductor Devices for Wireless Circuit and Optical Detection Applications]]></title_en><user_id>6955</user_id><user_firstLast_name>Tomislav Suligoj</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-9006</code><acronim><![CDATA[HiPerSemi]]></acronim><duration>25.08.2014 - 24.08.2018</duration><status>Završio</status><financ_value>119.848,70 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>7054, 5077, 6083, 6081, 7123, 7148, 7085, 17830, 6852, </team_members_id><team_members_names><![CDATA[Mirko Poljak, Sanja Žonja, Tihomir Knežević, Josip Žilak, Igor Krois, Dubravko Babic, Boris Sviličić, Sabina Krivec, Marko Koričić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[semicoductors, microelectronics, bipolar transistors, photodetectors, photodiodes, CMOS, modeling, MOSFET, RF circuits]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The objective of this project is to provide notable scientific contributions by designing and utilizing the advanced semiconductor devices for the wireless communication circuits and solid-state optical detection applications. Research in this project will be grouped in three major activities, which are: (i) Horizontal Current Bipolar Transistor (HCBT) for RF Wireless Circuits, (ii) Characterization and applications of solid-state photodetectors, and (iii) Modelling of MOS, photodetector and other advanced electron devices. The novel wireless RF communication circuits such as mixer, frequency divider, voltage-controlled oscillator, RF switch and power amplifier will be designed and fabricated in HCBT technology as the first such circuits using the HCBT as an active component. The measurements of noise, reliability and on-wafer uniformity as well as linearity, gain and efficiency will be performed on transistors and circuits. The characterization of material properties of pure amorphous boron (PureB) layers will be made in order to determine the composition, electrical and optical properties of the layer and to develop the model of charge carrier transport through it. They will be correlated with electrical measurements to find out currently-unknown physical mechanisms responsible for the current reduction and for the record-high performance of photodides with PureB layers. The investigation of the novel materials such as Ge, SiGe and GaN for ultra-scaled advanced CMOS structures, i.e. FinFETs, will be performed by the development of novel models and simulation environment. The analog/RF parameters and characteristics will be extracted for FinFETs with different geometries and materials in order to determine the optimum structure for future RF systems.]]></summary_en></project><project>
<id>2281</id><title_hr><![CDATA[Metode deidentifikacije za meke i ne-biometrijske identifikatore]]></title_hr><title_en><![CDATA[De-identification Methods for Soft and Non-Biometric Identifiers]]></title_en><user_id>6974</user_id><user_firstLast_name>Tomislav Hrkać</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2013-11</proposal_call><code>UIP-2013-11-1544</code><acronim><![CDATA[DeMSI]]></acronim><duration>01.09.2014 - 31.08.2017</duration><status>Završio</status><financ_value>68.410,64 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>4290, 6564, 6814, 4584, 6563, </team_members_id><team_members_names><![CDATA[Slobodan Ribarić, Zoran Kalafatić, Karla Brkić, Darijan Marčetić, Ivan Filković, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[De-Identification, Privacy Protection, Image Processing, Video Processing, Biometrics, Multimedia]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Advances in audio and video recording devices, web technology and signal processing have highly facilitated the efficacy of audio and video acquisition. This capability is now widely exploited in a variety of scenarios to obtain audio-video recordings of people, raising serious privacy concerns. The protection of sensitive private data is required by EU’s Data Protection Directive (95/46/EC). De-identification in multimedia content can be defined as the process of concealing identities of individuals captured in a given set of data, for the purpose of protecting their privacy. Soft biometric and non-biometric characteristics such as tattoos, birthmarks, scars or dressing style also carry potentially identity-revealing information and have to be dealt with in the process of de-identification. This is an interdisciplinary challenge, involving such scientific areas as image processing, video tracking and biometrics. This project proposal aims to development of novel and robust methods for de-identification of soft and non-biometric identifiers in videos and images.]]></summary_en></project><project>
<id>2283</id><title_hr><![CDATA[Arheološka istraživanja kasnog Pleistocena i ranog Holocena u Limskom kanalu, Istra ]]></title_hr><title_en><![CDATA[Archaeological investigations into the Late Pleistocene and Early Holocene of the Lim Channel, Istria]]></title_en><user_id>2764</user_id><user_firstLast_name>Ivor Janković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2013-11</proposal_call><code>UIP-2013-11-7789</code><acronim><![CDATA[ARCHAEOLIM]]></acronim><duration>15.06.2014 - 14.06.2017</duration><status>Završio</status><financ_value>79.368,24 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Arheologija, </scie_field_hr><scie_field_en>Archeology, </scie_field_en><institution_hr><![CDATA[Institut za antropologiju]]></institution_hr><institution_en><![CDATA[Institute for Anthropological Research]]></institution_en><team_members_id>3839, 3871, 6897, 4112, 3711, 3440, 4229, 6754, 2993, 21180, </team_members_id><team_members_names><![CDATA[James Ahern, Fred  Smith, Darko Komšo, Sanjin Mihelić, Jacobo Weinstock, Katarina Gerometta, Rory Becker, Krunoslav  Zubčić, Barbara Cvitkušić, Antonela Barbir, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Paleolithic, Mesolithic, Neandertals, archaeology, caves, Croatia, prehistory, Pleistocene, Holocene ]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The proposed project is aimed at archaeological research of four cave sites in the Lim Channel, Istria, where previous small-scale excavations and field survey documented human habitation during the Late Pleistocene and Early Holocene. It is expected that this work will provide data for understanding a number of important issues regarding behavioral and possibly biological aspects of human groups during a time when Late Glacial hunter gatherers were forced to change and adapt to a changing environmental and other pressures. Presence of Mousterian artefacts at one of the sites, and Upper Paleolithic tool types at another suggests two populations (i.e. Neandertals and anatomically modern humans) were present in the region during the Late Pleistocene. Data from the proposed excavations may provide a basis to test some of the highly debated questions regarding the relation of biological population to behavioral aspects (e.g. whether Neandertals or anatomically modern humans were responsible for Early Upper Paleolithic, is there a sharp distinction in behavior and anatomy between these groups etc. Furthermore, at one site early Mesolithic is documented, while at another Late Mesolithic is present, allowing similar issues regarding behavior and other aspects to be tested, including issues related to the transition to Neolithic (agricultural) lifestyle. A comparison of data between all four sites could provide us with a basis for testing of issues related to changing life ways, land use, movement patterns, site use, biological aspects (similarities and differences), contact zones, mobility, continuity, etc. at times of changing climatic and environmental conditions and thus help us to understand this crucial time period, in particular, and how humans respond to such changes, in general. Results from the project will also provide a basis for development of archaeology–based tourism and thus directly benefit the local community and Croatian economy in the long run.]]></summary_en></project><project>
<id>2284</id><title_hr><![CDATA[Unaprijeđeno istraživanje općekorisnih funkcija šuma]]></title_hr><title_en><![CDATA[Advanced Forest Environmental Services Assessment]]></title_en><user_id>7009</user_id><user_firstLast_name>Ivan Pilaš</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-1924</code><acronim><![CDATA[AFORENSA]]></acronim><duration>01.07.2014 - 30.06.2018</duration><status>Završio</status><financ_value>111.752,60 eur</financ_value><scie_area_hr>Biotehničke znanosti, Tehničke znanosti, </scie_area_hr><scie_area_en>Biotechnical sciences, Technological sciences, </scie_area_en><scie_field_hr>Biotehnologija, </scie_field_hr><scie_field_en>Biotechnology, </scie_field_en><institution_hr><![CDATA[Hrvatski šumarski institut]]></institution_hr><institution_en><![CDATA[Croatian Forest Research Institute]]></institution_en><team_members_id>3207, 3290, 7002, 3272, 5644, 5659, 5655, 17863, 3478, </team_members_id><team_members_names><![CDATA[Damir Medak, Ivan Medved, Dražen Odobašić, Ela Vela Bagić, Jasnica Medak, SANJA PERIĆ, MARTINA TIJARDOVIĆ, Luka Rumora, Mario Miler, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Forest environmental services, Remote sensing, Ecohydrology, Biodiversity, GIS, Climate change ]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The main objective of AFORENSA is to generate relevant knowledge how the forest ecosystems in Croatia responds to observed extreme climatic variations, and what are possible future expectations in respect to the progression of climate change and disturbances of natural hydrologic cycle with intensification of drought frequency and severity. This objective is aimed to be resolved by implementing of the novel forest ecosystem assessment approach, applicable for the country scale, which incorporates: a) traditional in situ ecosystem survey (soil and vegetation), b) analysis of the functional state of the ecosystems by remote sensing, c) downscaling of the regional climatic models and d) coupling of scenario outputs with ecohydrological models on a site specific environmental settings. The core system on which AFORENSA activities will be build up, presents “Dynamical Geoinformation system of forest ecosystems in Croatia” (DYN-CROFOR), a technological project financed by the Ministry of Science and Education from 2003 to 2007. Aforensa is aiming at the inventory, and integration of terrestrial forest ecosystem research on the Web-Gis (DYN-CROFOR) platform incorporating automatized procedures for retrieving remote sensing data (such as MODIS and MERIS vegetation indices)  and with the  addition of incorporating Data mining procedures and the full power of R, a language and environment for statistical computing and graphics. Project workflow consists of four, interrelated, work packages: a) INVENTORY, b) AUTOMATIZATION, c) MINING, d) UPGRADING. AFORENSA will contribute with speeding-up of future exploratory forest ecosystem research, and with its capability of near real time data processing will present a basis for the development of “Forest watch”; an observatory for early determination of potentially harmful effects of Climate Change on forest ecosystem services such as biodiversity and water.]]></summary_en></project><project>
<id>2291</id><title_hr><![CDATA[Tekstualne mreže ranonovovjekovne Hrvatske]]></title_hr><title_en><![CDATA[Textual networks of early modern Croatia]]></title_en><user_id>2952</user_id><user_firstLast_name>Lahorka Plejić Poje</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-4785</code><acronim><![CDATA[TeMrežaH]]></acronim><duration>15.11.2014 - 15.11.2018</duration><status>Završio</status><financ_value>47.375,41 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filologija, </scie_field_hr><scie_field_en>Philology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu]]></institution_hr><institution_en><![CDATA[University of Zagreb]]></institution_en><team_members_id>1416, 5337, 3921, 4025, 4310, 5006, 5066, 5024, 4860, 3931, 6715, 7050, 4221, 7251, 7383, </team_members_id><team_members_names><![CDATA[Neven Jovanović, Irena Bratičević, Tomislav Bogdan, Tamara Tvrtković, Violeta Moretti, Francesca Maria Gabrielli, Dolores Grmača, Bratislav Lučin, Šime Demo, Gorana Stepanić, Dunja Fališevac, Vladimir Rezar, Jasmina Lukec, Darko Novaković, Luka Špoljarić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[scholarly edition, early modern Croatian literature, digital humanities, Renaissance, Baroque, 18th century]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[We propose to establish a collaborative framework for scholarly editions of Croatian early modern written heritage, regardless of its linguistic medium (Croatian, Latin, Italian, German) and its material manifestation (manuscripts, printed books, digital texts). A significant part of this heritage is still not easily or reliably accessible to modern scholarship. Leveraging current European and international achievements and initiatives, our project will solve textual and editorial problems through scholarly collaboration, in that way providing grounds and opportunity for further interpretative insights about the life of the texts. The project will prepare and publish both printed and digital editions; editorial work of team members will be submitted to early collective peer review and discussion. The proposed framework will also serve as a training ground for next generations of textual scholars studying early modern Croatian literature; researchers of all career stages (including undergraduate, graduate, and PhD students) will be offered an opportunity to make their first contributions, also peer-reviewed and carefully attributed. Through these innovative procedures we aim to reinterpret scholarly edition as a fruitful and exciting interpretative undertaking, without which there can be no real understanding of our intellectual history. The main outcome of our project will be 15 scholarly editions published over four years: six texts of Croatian authors in Croatian (Mršić, Primović, Palmotić Dionorić, Divković, the Kajkavian miscellany of Nikola Šafran, M. Zlatarić), an edition of three Croatian woman writers in Italian (G. and S. Bona, M. Gondola Gozze), and eight texts of Croatian authors in Latin (Nikola Modruški, Marulić, Beneša, V. Gučetić, Ritter Vitezović, Tomko Mrnavić, M. Zlatarić, the Macaronica Croatica).]]></summary_en></project><project>
<id>2299</id><title_hr><![CDATA[Evlija Čelebi i Hrvati, nove perspektive]]></title_hr><title_en><![CDATA[Evliya Chelebi and Croats, new perspectives]]></title_en><user_id>98</user_id><user_firstLast_name>Nenad Moačanin</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-9215</code><acronim><![CDATA[EvliyaChelebi]]></acronim><duration>01.08.2014 - 30.11.2017</duration><status>Završio</status><financ_value>59.725,26 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Povijest, </scie_field_hr><scie_field_en>History, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>6011, 6728, 6807, 7081, </team_members_id><team_members_names><![CDATA[Kornelija Jurin Starčević, Vjeran Kursar, Ekrem Čaušević, marta andrić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Evliya Chelebi, Travelouge, Croatia, History, Language, Critical Edition, Ottoman Studies]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Thirty years ago the autograph of the Evliya Chelebi&#39;s travelogue (SeyahatnameorBook of travels) was found. Evliya Chelebi is the most famous Ottoman traveller and writer and the worldwide cited Ottoman author. His Seyahatname in Ottoman was recently  published in Istanbul in ten volumes. For Croatian history the volumes V, VI and partly VII have the paramount significence.A critical edition and translation of the autograph’ssections of the books V, VI and VII into Croatian language does not exist. HazimŠabanović made translation on the basis of a printed version from 1900 which was done upon an inaccurate, even censored copy. The translator himself had shortened the narrative in many places. Even a brief insight in original text shows dramatical differences and alterations in quantity of text (there is up to 35 percent more text in  the autograph)  and quality of  informations (substantially new informations, thoroughly different from those in Šabanović&#39;s translation). The aim of the project is to investigate this „missing link“ among the narrative sources for Croatian history in Early Modern Period, i.e. to scrutinize the autograph, to translate parts of the V, VI and VII book with commentaries and footnotes, and to produce supporting articles. A picture of Croatian societies in different political frames which is given in the Seyahatname has never been a subject of scholarly research. This would lead toward the comprehensive explanation and interpretation of early modern national integration, ecohistorical determinants, social and ethnoconfessional  structures and processes. Such a project is expected to contribute substantially to filling the gaps in the historiography, to establish a more balanced perception of the past, along with the improvement of mutual understanding between Croatia and Turkey, with positive effect in the Southeastern Europe. Also, this project can significantly contribute to the  revitalization of the Ottoman heritage in Croatia.]]></summary_en></project><project>
<id>2307</id><title_hr><![CDATA[Metakognicija kod kategorijalnog učenja, mišljenja i razumijevanja]]></title_hr><title_en><![CDATA[Metacognition in Category Learning,  Thinking and Comprehension]]></title_en><user_id>4615</user_id><user_firstLast_name>Dražen Domijan</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-4139</code><acronim><![CDATA[METCALTHIC]]></acronim><duration>01.10.2014 - 30.09.2017</duration><status>Završio</status><financ_value>52.918,57 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Psihologija, </scie_field_hr><scie_field_en>Psychology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Filozofski fakultet u Rijeci]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>4612, 6976, 568, 7004, 5747, 7169, 6968, 6882, 6892, 17886, </team_members_id><team_members_names><![CDATA[Igor Bajšanski, Pavle Valerjev, Valnea Žauhar, Mia  Šetić, Marija Šakić, Vladimir Takšić, Tanja Gulan, Maja Močibob, Nena Vukelić, Mateja Marić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[metacognition, monitoring, dual processes, category learning, thinking, comprehension]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The fundamental problem of education is how to create a learning environment which will facilitate the acquisition of knowledge and skills. Psychology of education attempts to identify mental processes and mechanisms underlying our ability to learn. Research on self-regulated learning and metacognition is a topic of special importance for educational psychology. Self-regulated learning encompasses cognitive, motivational and behavioral processes which occur while learners undertake activities to accomplish a learning goal. Self-regulation is based on a cyclical process of monitoring and control. The learner monitors the efficiency of the applied learning strategies and responds to feedback obtained from the monitoring process. Metacognition is studied intensively in the areas of memory and text comprehension. The central aim of the project is to explore metacognitive processes of monitoring and control in the domains of: 1. Category learning, 2. Thinking, 3. Grounded (situated) comprehension. All of these domains have been studied extensively but in isolation from metacognition. Our goal is to bring together these disparate fields of study under the same research program. Unifying theme of the project is the distinction between Type 1 and Type 2 processes which can be identified in each domain and whose properties will guide metacognitive judgments. Project team consists of 5 established researchers in the field of experimental psychology and 5 doctoral students whose PhD theses are closely related to the project aims. The project team will utilize newly established Laboratory for experimental psychology equipped with facilities necessary to carry out the proposed project. The project will answer the important question of how accurate are the metacognitive judgments and how effective are the processes of monitoring and regulation in the cognitive domains where metacognition has not been studied in greater detail.]]></summary_en></project><project>
<id>2314</id><title_hr><![CDATA[Višeagentno modeliranje velikih razmjera za MMORPG mrežne igre ]]></title_hr><title_en><![CDATA[Large-scale Multi-Agent Modelling of Massively Multi-player On-line Role-Playing Games]]></title_en><user_id>891</user_id><user_firstLast_name>Markus Schatten</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2013-11</proposal_call><code>UIP-2013-11-8537</code><acronim><![CDATA[ModelMMORPG]]></acronim><duration>01.10.2014 - 30.09.2017</duration><status>Završio</status><financ_value>66.421,61 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Informacijske znanosti, </scie_field_hr><scie_field_en>Information sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet organizacije i informatike]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Organization and Informatics]]></institution_en><team_members_id>1428, 1412, 899, 918, 2900, 2725, 2508, 2577, 950, 17828, 21330, </team_members_id><team_members_names><![CDATA[Mladen Konecki, Jurica Ševa, Joaquim  Filipe, Pietro Terna, Nikola Ivković, Ivan Magdalenić, Igor Tomičić, Robert Kudelić, Marko Maliković, Bogdan Okreša Đurić, Mario Konecki, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[large-scale multi-agent systems, agent based modeling, mmorpg, organizational methods, organizational design, artificial intelligence]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Massively multi-player on-line role playing games (MMORPGs) give us the opportunity to study two important aspects of computing: (1) large-scale virtual social interaction of people (players) and (2) the design, development and coordination of large-scale distributed artificial inteligence (AI). A common denominator for both aspects are the methods used to study them: social interaction can be descibed and simulated using agent-based models (ABM social science perspective) whilst distributed AI is commonly modelled in terms of multi-agent systems (MAS computer science perspective). The important question to ask in both perspectives is how do agents organize in order to perform their tasks and reach their objectives? Herein we will employ a combined empirical and theoretical approach towards finding the answer to this question.From the empirical side, we shall study the human behaviour on a number of venues across various gaming servers in order to find most suitable structures, cultures, processes, strategies and dynamics employed by most successful player communities.  From the theoretical side, we shall test a multitude of organizational architectures from organization theory in various MMORPG settings, and compare them with methods found in empirical research.Our research is therefore aimed towards enriching the organizational design methods for the development of MMORPG to foster the development of self-organizing and adaptable networks of large-scale multi-agent systems.With this in mind, our main goals are:1) To identify and formalize adequate organizational design methods for developing LSMAS in MMORPGs.2) To couple them with real-life and future scenarios from industry.3) To provide open and accessible tools, which will allow for design, development, implementation, control, simulation and maintenance of LSMAS in MMORPG.]]></summary_en></project><project>
<id>2317</id><title_hr><![CDATA[Ekonomski i socijalni učinci reformi energetskog sektora na održivi ekonomski rast]]></title_hr><title_en><![CDATA[Economic and social effects of energy sector reforms on sustainable economic growth]]></title_en><user_id>211</user_id><user_firstLast_name>Nela Vlahinić-Dizdarević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-2203</code><acronim><![CDATA[ESEESRSEG]]></acronim><duration>01.06.2014 - 31.05.2018</duration><status>Završio</status><financ_value>68.630,13 eur</financ_value><scie_area_hr>Društvene znanosti, Tehničke znanosti, </scie_area_hr><scie_area_en>Social sciences, Technological sciences, </scie_area_en><scie_field_hr>Ekonomija, </scie_field_hr><scie_field_en>Economy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Ekonomski fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Economics and Business]]></institution_en><team_members_id>2915, 2618, 6336, 19024, 6206, 7269, </team_members_id><team_members_names><![CDATA[Saša Žiković, Pavle Jakovac, Rafal Weron, Ivan Gržeta, Ana-Maria Boromisa, Đula Borozan, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[energy sector, reforms, economic effects, social effects, sustainable economic growth, Croatia, European Union]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Sustainable economic growth needs a sustainable energy supply. In order to accomplish this goal, good economic governance incorporating energy policy should implement reforms that will increase economic efficiency and social prosperity. The sector’s reform experience goes back to the beginning of 1990s, indicating that existing literature has been limited by a relatively short period of time, inadequate hypothesis cross-testing and without appropriate panel-data analysis. Therefore there is a strong need for the systematic analysis that would include EU countries and Croatia as the new EU Member State, a broader range of issues related to energy sector reforms within a longer time frame to examine whether the empirical evidence supports the logic of reforms and to compare the existing evidence on the reform determinants and performance. So far the findings on some issues have been limited and inconclusive. The goal of the research is to better understand the reform process by providing solid economic evidence on energy reform results and its economic and social impacts on sustainable growth. The aim of the research within this project is to address several related issues: 1) internal and external factors that will further influence the progress of reforms, especially in the EU; 2) macroeconomic performance, institutional settings, regulatory prudence and sector governance as the important wider framework; 3) measuring the economic impact of energy reforms in terms of economic efficiency, rate of investments, competitiveness and economic growth; 4) testing the existing risk management models and developing a novel approach to assessing and hedging the risks in the energy market; 5) measuring the social impact of energy reforms in terms of coverage of energy services and welfare; 6) evaluation of the energy reforms impact on long-term and sustainable economic growth. The research will be performed by combining economic and technical approach and research methods.]]></summary_en></project><project>
<id>2322</id><title_hr><![CDATA[Istraživanje inovativnih zelenih tehnologija na kampusima za potrebe održivog društva]]></title_hr><title_en><![CDATA[Innovative Green Building Research in the Campus Living Lab]]></title_en><user_id>7223</user_id><user_firstLast_name>Bojan Baletić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-8596</code><acronim><![CDATA[CampusLivingLAB]]></acronim><duration>01.09.2014 - 31.08.2017</duration><status>Završio</status><financ_value>98.347,60 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Arhitektura i urbanizam, </scie_field_hr><scie_field_en>Architecture and Urban Environment, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Arhitektonski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Architecture]]></institution_en><team_members_id>7216, 7232, 5972, 7319, 7503, 7540, 7520, 3715, </team_members_id><team_members_names><![CDATA[Roberto Vdović, Morana Pap, Rene Lisac, Kristina Careva, Mladen Jošić, Ljubomir Miščević, Velimir  Tolić, Zoran Veršić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Architecture, Campus, Green technology, Sustainable Development, Innovative Design]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The aim of the project is to research and develop an innovative model for a green building (based on student housing) on the campus that could be certified as A+ by applying new materials and technologies, the climate sensitive design approach and testing the possible alternatives with the future users in alignment with the Living laboratory principles.Our research is an extension of the present green campus multidisciplinary research and development. It belongs in the architecture domain, but it also includes interdisciplinary participation from other professions. We refer to the university campus Borongaj in Zagreb as an explicit framework of our research. The plan is to build it as a green campus with the highest level of energy efficiency. In its full form, that campus should be a place for studying, working, learning and living for about 20,000 academic citizens. For that reason, it was necessary to design a complex system and implement cutting-edge green technology and energy efficiency principles: bioclimatic principles of renewable energy sources, advanced technology, smart systems, and user adoptation of the new environment and technology within the methodology of the living laboratory concept.In the proposed three year project the team would research new materials, building elements and construction methods to define those appropriate for implementation. Using Building Information Management software and sustainable design principles the team will develop alternative building proposals that will be analyzed based on detailed energy, cost/benefit and quality of life simulations. The input from the construction industry is also planned. The third phase of the project is a testing phase in which, through student surveys and direct input from a selected group of students, the team expects to refine the proposals. In the end the research result needs to be evaluated within the high expectations of the green campus concept.]]></summary_en></project><project>
<id>2330</id><title_hr><![CDATA[Primjena nusproizvoda prehrambene industrije za razvoj funkcionalnih i okolišno prihvatljivih ekstrudiranih proizvoda i aditiva ]]></title_hr><title_en><![CDATA[Application of food industry by-products in development of functional and environmentally friendly extruded food products and additives]]></title_en><user_id>6031</user_id><user_firstLast_name>Drago Šubarić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-1321</code><acronim><![CDATA[FUNEXFOOD]]></acronim><duration>16.06.2014 - 15.06.2018</duration><status>Završio</status><financ_value>117.902,01 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Prehrambena tehnologija, </scie_field_hr><scie_field_en>Food technology, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Prehrambeno-tehnološki fakultet]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Food Technology]]></institution_en><team_members_id>5709, 6520, 4090, 6811, 5095, 5982, 5097, 5093, 4578, 3836, 5723, 4879, 6084, 17789, </team_members_id><team_members_names><![CDATA[Antun Jozinović, Marko Jukić, Indira Kosović, Daliborka Koceva Komlenić, Gordana Šimić, Dijana Miličević, Alojzije Lalić, Jurislav Babić, Đurđica Ačkar, Stela Jokić, Borislav Miličević, Biljana Pajin, Midhat Jasic, Jelena Panak, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Functional food, extrusion, cereals, flours, by-products, environment-friendly]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Consumers nowadays are seeking palatable food which has beneficial effect on health. At the same time, they are not ready to change their eating habits – reduce intake of bakery products, fast food etc. and increase intake of fresh fruit and vegetable, whole grain products etc. Therefore, food industry is challenged to create products that are consumed every day (bread, snacks etc.) by large population, which are both enriched with bioactive substances and have desired sensory properties.The aim of this project is to develop new functional and enriched products based on extrusion process. Enriched grains (wheat, maize) will be used as basic material. The improvement and supplementation with biologically active (antioxidants, minerals, vitamns, fibre) will be done by addition of by-products from food industry (fruit and vegetable pomaces, oil cakes) in extrusion process. Extrusion will be used to produce final products: expanded snack products and pasta, as well as modified flours which will be used in production of bakery products and biscuits.All processes - extrusion of snack products and pasta, extrusion for flour modification, pasta drying, baking) will be optimised using response surface methodology. All products will be tested for chemical, physical, thermophysical properties, and optimal products will be sensory analysed.The results of project will be array of flours and final products with defined recipes and optimal production conditions, along with defined application of food industry by-products that significantly load environment and are not currently exploited to satisfying extent.In the project multidisciplinary approach will be applied – from agronomist, over food technologist and process engineers to sensory experts. In addition, close academia-industry links will be developed through different activities.]]></summary_en></project><project>
<id>2332</id><title_hr><![CDATA[Trehaloza: poboljšanje kvalitete proizvoda na bazi voća]]></title_hr><title_en><![CDATA[Trehalose: fruit product quality improvement]]></title_en><user_id>7246</user_id><user_firstLast_name>Mirela Kopjar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2013-11</proposal_call><code>UIP-2013-11-6949</code><acronim><![CDATA[TrehaMovement]]></acronim><duration>01.09.2014 - 31.08.2017</duration><status>Završio</status><financ_value>93.202,73 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Prehrambena tehnologija, </scie_field_hr><scie_field_en>Food technology, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Prehrambeno-tehnološki fakultet]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Food Technology]]></institution_en><team_members_id>7296, 7330, 7400, 7405, 7410, </team_members_id><team_members_names><![CDATA[Anita Pichler, Josip Simunovic, Nela Nedić Tiban, Ante Lončarić, Tomaž Požrl, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[trehalose,  fruit products, colour, aroma, texture, trehalose action ]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Trehalose is a nonreducing disaccharide which consists of two D-glucose units linked by a-a (1-1)-linkage and occurs widely in nature. Its unique hydration structure enables it to interact with both hydrophilic and hydrophobic molecules which probably contribute to the multifunctional character of trehalose. The major applications of trehalose have been in science, medicine and cosmetic sectors due to its natural functionality, mechanism of action and technical qualities. The limiting factor of trehalose use in the food industry used to be the ingredient cost but with development of a new manufacturing process, the cost of trehalose production has been dramatically reduced. It is about 45% as sweet as sucrose and very stable under processing and storage conditions. Texture, colour and aroma are the main quality attributes influencing consumer acceptability of fruit products. During formulation of fruit products different additives are often used to obtain desired properties of semi-products or final products. The aim of this project is investigation of the influence of trehalose on fruit product quality with emphasis on the explanation of trehalose mechanism of action in complex fruit product matrices. Practical application of project results would be valuable for new food product development. Through addition of trehalose to fruit product the retention of key aroma compounds, and prevention of colour degradation could be achieved, ensuring in this way more fresh-like characteristics of the final product. Also, through retention of phenols, especially pigments, such as anthocyanins, which are known for their antioxidant properties, obtained products would have higher nutritional value, as well as organoleptic properties.]]></summary_en></project><project>
<id>2333</id><title_hr><![CDATA[Komparativnoslavističke lingvokulturalne teme]]></title_hr><title_en><![CDATA[Comparative Slavic Linguocultural Themes]]></title_en><user_id>3640</user_id><user_firstLast_name>Neda Pintarić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-2131</code><acronim><![CDATA[KOMPAS]]></acronim><duration>01.09.2014 - 31.08.2018</duration><status>Prekinut</status><financ_value>61.862,10 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filologija, </scie_field_hr><scie_field_en>Philology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>6803, 5453, 6916, 3642, 6906, 5457, 4124, 5183, 7079, 7046, 6970, 5456, 5554, 5446, 7052, 6367, 5365, 7341, 5571, 7361, </team_members_id><team_members_names><![CDATA[Dubravka Sesar, Ivana Vidović, Aleksandra Welna, Miroslav Hrdlička, Jerzy Molas, Josip  Lasić, Ivana Čagalj, Ana Vasung, Elżbieta Wrocławska, Slavomira Ribarova, Martina Grčević, Szerszunowicz Joanna, Oksana Timko Đitko, Borjana Prošev-Oliver, Lidija Cvikić, BARBARA POPIOŁEK, Anita Skelin Horvat, Ewa Komorowska, Marinela  Aleksovski, Branko Kuna, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Slavistics, Culturology, Pragmatics, Sociolinguistics, Phraseology, Lexicology, Stylistics, Language History, Gtottodidactics]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The Project will include linguocultural themes from Slavic philology with an emphasis on Croatian language using a contrastive/comparative method of research. Languages included are: Polish, Czech, Slovak, Ukraine, Russian, Sorabian, Macedonian, Bulgarian and other Slavic languages.Linguocultural  areas cover grammatical fields: phonology, inflexion, word- formation, lexicology, phraseology, micro -, macro- and suprasyntax and wider areas of interest are: pragmatics, paremiology, language history and semantics. Interdisciplinary areas, such as: ethno linguistics, sociolinguistics, psycholinguistics with a special emphasis on verbal and non-verbal communication are also taken into consideration. On the basis of this a connection of the language and culture in presenting the language world view will be presented.As a part of the Project specialized bilingual dictionary “Pragmaticon” and Quintilingual dictionary of Slavic etymons. ]]></summary_en></project><project>
<id>2335</id><title_hr><![CDATA[Napredni elektromotorni pogoni za primjene u vuči]]></title_hr><title_en><![CDATA[Advanced Electric Drives for Traction Applications]]></title_en><user_id>3873</user_id><user_firstLast_name>Damir Žarko</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-7801</code><acronim><![CDATA[ELTRAC]]></acronim><duration>01.10.2014 - 30.09.2018</duration><status>Završio</status><financ_value>128.940,21 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>1505, 1528, 2534, 2524, 2674, 2703, 2913, 3279, 3953, 3938, 5856, 6481, 7357, 18971, 17824, </team_members_id><team_members_names><![CDATA[Goran Rovišan, Stjepan Stipetić, Marinko Kovačić, Željko Jakopović, Ivan Mrčela, Mario Vražić, Viktor Šunde, Tanja Poljugan, Zlatko Hanić, Ivan Gašparac, Neven Čobanov, Šandor Ileš, Fetah Kolonić, Ana Hanić, Tino Jerčić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[electric traction, electric drives, energy efficiency, optimization, life cycle cost, control of electric drives, power electronics, electric machines]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The development of more efficient transport equipment and reduction of their environmental footprint is in the scope of the energy policy of the EU. The electrification of the transport equipment and the shift of the freight shipments from road to more efficient rail are some of the key elements for the overall increase of energy efficiency in transport and reduction of the greenhouse gas emissions. This project puts emphasis on development of advanced electric drives for traction vehicles for passenger and freight transport running on tracks. Traditional approach to the design of electric drives has an emphasis on components without insufficient insight into the interaction among them and thus it fails to deliver the optimal performance of the overall traction system. The main objective of this project is to enhance the general approach to design of electric drive systems for traction applications by utilizing a synergetic approach to component design accompanied with advanced control algorithms to maximize the system performance and efficiency and minimize the life cycle cost of the vehicle. This objective will be achieved through: (i) development of software tools for computer aided design of electric drive components for traction applications using multiphysics approach with consideration of component interaction with the rest of the system, (ii) development of different traction power converters topologies for evaluation of various modulation and control methods, (iii) development of software environment for dynamic simulation of traction system performance which couples complex nonlinear models of system components with the models of control algorithm and vehicle dynamics, (iv) development of the electric drive control system based on optimal control approach which ensures maximum efficiency of the system during entire drive cycle of the vehicle. The developed algorithms will be experimentally tested on the scaled model of the traction system.]]></summary_en></project><project>
<id>2338</id><title_hr><![CDATA[ISTRAŽIVANJE JAVNE POTROŠNJE NA OBRAZOVANJE: UTJECAJ NA RAST, KONVERGENCIJA I EFIKASNOST]]></title_hr><title_en><![CDATA[INVESTIGATING GOVERNMENT SPENDING ON EDUCATION: GROWTH EFFECTS, CONVERGENCE AND EFFICIENCY]]></title_en><user_id>1210</user_id><user_firstLast_name>Lena Malešević Perović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2013-11</proposal_call><code>UIP-2013-11-9558</code><acronim><![CDATA[GOVSPENDEDU]]></acronim><duration>15.09.2014 - 14.09.2017</duration><status>Završio</status><financ_value>27.951,49 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, </scie_field_hr><scie_field_en>Economy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Ekonomski fakultet]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Economics, Business and Tourism]]></institution_en><team_members_id>2515, 2526, </team_members_id><team_members_names><![CDATA[Maja Mihaljevic Kosor, Silvia Golem, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[PUBLIC SPENDING, EDUCATION, GROWTH, CONVERGENCE, EFFICIENCY]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[More and more governments are increasingly recognising the importance of human capital for growth and prosperity of their countries; moreover, European Commission has stated education as one of its key 2020 goals. These plans are, however, in contrast with the EU fiscal policies which are faced with constraints as regards deficits and public debts. Public spending on education should, therefore, be given special attention. This research project, consequently, has three main goals, which are as follows: to analyse the relationship between public spending on education and GDP growth; to investigate whether there is a convergence between public spending on education among the EU countries and to analyse the efficiency of public spending on education in the EU countries.  ]]></summary_en></project><project>
<id>2342</id><title_hr><![CDATA[Statističko modeliranje odgovora na krizu i ekonomskog rasta zemalja Zapadnog Balkana]]></title_hr><title_en><![CDATA[Statistical Modelling for Response to Crisis and Economic Growth in Western Balkan Countries]]></title_en><user_id>3292</user_id><user_firstLast_name>Ksenija Dumičić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-9402</code><acronim><![CDATA[STRENGTHS]]></acronim><duration>01.09.2014 - 31.01.2019</duration><status>Završio</status><financ_value>51.536,00 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, </scie_field_hr><scie_field_en>Economy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Ekonomski fakultet u Zagrebu]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Economics and Business]]></institution_en><team_members_id>6268, 3738, 3373, 3372, 3492, 3285, 3464, 4258, 6350, 3528, 4043, 3608, 3669, 3727, </team_members_id><team_members_names><![CDATA[Vlasta Bahovec, Ivan Strugar, Anita Čeh Časni, Irena Palić, Berislav Žmuk, Dajana Cvrlje, Silvija Vig, Vesna Bucevska, Lea Bregar, Emina Resić, Mirna Dumičić, Ivan Huljak, Zrinka Marušić, Iris Mihajlović, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Econometric Modelling, Panel Data Analysis, Mathematical Programming, Multivariate Analysis Methods, Survey Research Design]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Recent economic downturn has forced policy makers to pay attention both not only on the economic growth, but as well on risk prevention. However, intelligent decision cannot be made without previous thorough analysis using appropriate methods. Project “STatistical modelling for Response to crisis and EcoNomic GrowTH in Western Balkan countrieS” (STRENGTHS) aims to support joint action of analysts, managers and policy makers, which is crucially needed in order to attain the goal of prosperity. Project team members are leading reserachers from Croatian, Slovenian, Bosnia and Herzegovina and Macedonian HEIs, researchers from the corporate world, and National Bank of Croatia. Prinicipal investigator and researchers have identified number of goals as significant for the crisis prevention and economic growth, which cannot be achieved without the insight acquired as a result of thoughtful statistical analysis. Crisis prevention topics will be investigated: Risk and financial management modelling, Commitment to business ethics and its influence on a corporation&#39;s performance, Efficiency of macroprudential measures and measuring financial stability, and Statistical modelling of the impact of macroeconomic shocks on small open economy. Economic growth topics will be investigated: Statistical modelling of housing wealth effect on personal consumption in selected WB countries, Modelling migration from the EU candidate countries, Impact of statistical methods usage to business performance, Estimating the value of public goods in tourism: Application of Contingent Valuation Method on the Case of Croatia, Strategic impact of the Internet usage on the tourism industry, and The net effect of bank market power in CEE countries. These goals will be achieved by the survey research, thoroughly prepared researched instruments, and usage of cutting-edge statistical methods (Econometric Modelling, Panel Data Analysis, Mathematical Programming, and Multivariate Methods).]]></summary_en></project><project>
<id>2349</id><title_hr><![CDATA[Modeliranje toka podzemnih voda u krškim vodonosnicima]]></title_hr><title_en><![CDATA[Groundwater flow modelling in karst aquifers]]></title_en><user_id>6687</user_id><user_firstLast_name>Hrvoje Gotovac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2013-11</proposal_call><code>UIP-2013-11-8103</code><acronim><![CDATA[Karst modelling]]></acronim><duration>01.10.2014 - 31.01.2018</duration><status>Završio</status><financ_value>127.148,45 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Građevinarstvo, </scie_field_hr><scie_field_en>Civil engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu Fakultet građevinarstva, arhitekture i geodezije]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Civil Engineering, Architecture and Geodesy]]></institution_en><team_members_id>6169, 6989, 7099, 6856, 7030, 6042, 7164, 17887, 21318, </team_members_id><team_members_names><![CDATA[Vedrana Kozulić, Blaž Gotovac, Roko Andricevic, Vinko Jovic, Veljko Srzić, Ivo Andrić, Srdjan Simunovic, Luka Malenica, Grgo Kamber, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[karst aquifers, groundwater flow modeling, multiresolution and multiscale approach, karst heterogeneity, distributive karst models]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Karst aquifers are very important groundwater resources around the world as well as in coastal part of Croatia. They consist of extremely complex structure defining by triple phases: slow porous medium, mostly laminar fractures and usually fast turbulent conduits/karst channels. Usually, karst aquifers have been analyzed by lumped hydrological models which ignore high heterogeneity of karst and consider only input (precipitation) and output (spring discharge) due to lack of extensive other input data and knowledge regarding the karst system. Last two decades full hydraulic (distributive) models have been developed exclusively by conventional finite elements considering karst heterogeneity structure that improves our understanding of complex processes in karst. Therefore, in this project we will develop novel “unique” flow model based on multi-resolution approach originally designed by Gotovac et al. (2007-2013) for 1-D and 2-D groundwater flow and transport simulations. Proposed approach is based on Fup basis functions with compact support and meshless collocation procedure enabling multi-scale representation of heterogeneity and other flow variables, closely related to the karst flow physical interpretation. Moreover, extending existing procedure to 3-D and constructing separate multi-scale solution for all three karst phases, proposed approach will enable the following impacts in comparison to conventional methods: desired spatial and temporal accuracy and high computational efficiency, modular model structure, incorporation of different heterogeneity scales related to existing measurements, enabling of transport and tracer test analysis and better understanding of karst aquifers due to solving of different engineering problems such as water usage and protection or contaminant pollution. Flow model will be verified by laboratory experiments and numerical synthetic benchmarks as well as real examples such as Jadro catchment and Ombla underground accumulation.]]></summary_en></project><project>
<id>2351</id><title_hr><![CDATA[Upravljanje prostorno distribuiranim dinamičkim sustavima]]></title_hr><title_en><![CDATA[Control of Spatially Distributed Dynamical Systems]]></title_en><user_id>7315</user_id><user_firstLast_name>Andrej Jokić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2013-11</proposal_call><code>UIP-2013-11-9354</code><acronim><![CDATA[ConDis]]></acronim><duration>01.09.2014 - 31.08.2017</duration><status>Završio</status><financ_value>121.401,55 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, </scie_field_hr><scie_field_en>Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>6421, 5441, 6544, 6498, 6493, 17859, </team_members_id><team_members_names><![CDATA[Vladimir Milić, Marko Jokić, Josip Kasać, Mladen Crneković, Tihomir Žilić, Mihael Lobrović, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[control systems, distributed control, optimization, large-scale systems, vibrations]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Following impressive developments in communication and information technologies, but also in sensor and actuator technologies, a whole set of novel products and systems has emerged, which only recently seemed unfeasible. Examples of such systems include the so-called smart structures composed of a large number of sensors and actuators mounted on constructive elements (beams/plates) with the goal to damp undesired vibrations or to control flow of fluids; adaptive optics with large amount of optical elements; smart electrical power systems; highways with automated cars driving in platoons. Common characteristic of all of the above mentioned systems is that they are composed of a large number of spatially distributed dynamical subsystems which operate under constant mutual interactions through some physical interconnections (network) and/or communication links (network). Today, it is widely acknowledged that the key challenge in development of such dynamical networks is synthesis of algorithms for their control. The main goal of this project is development of some of the key elements in fundamental theory of control for spatially distributed systems, together with constructive controller synthesis algorithms suitable for application in real-life problems. The research focus will be on distributed control solutions in which each dynamical system in the network is controlled by its local controller and each local controller communicates and coordinates its actions with a (usually small) set of directly neighboring controllers. Our approach will be based on innovative elements from the theory of dissipative systems, while both spatially invariant networks and generic dynamical networks with arbitrary interconnection graph will be considered. The developed control algorithms will be verified in laboratory experiments on groups of mobile robots and on a distributed vibration control platform.]]></summary_en></project><project>
<id>2352</id><title_hr><![CDATA[Europska bioetika na djelu]]></title_hr><title_en><![CDATA[European Bioethics in Action]]></title_en><user_id>4099</user_id><user_firstLast_name>Amir Muzur</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-7853</code><acronim><![CDATA[EuroBioAct]]></acronim><duration>15.09.2014 - 14.09.2017</duration><status>Završio</status><financ_value>50.434,67 eur</financ_value><scie_area_hr>Humanističke znanosti, Društvene znanosti, Biomedicina i zdravstvo, </scie_area_hr><scie_area_en>Humanities, Social sciences, Biomedicine and health sciences, </scie_area_en><scie_field_hr>Filozofija, </scie_field_hr><scie_field_en>Philosophy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Medicine]]></institution_en><team_members_id>6036, 5496, 5108, 5105, 6779, 5129, 5896, 5503, 6539, 5594, 21391, </team_members_id><team_members_names><![CDATA[Ante  Čović, Robert Doričić, Igor Eterović, Nada Gosić, Željko Kaluđerović, Iva Rinčić, Tomislav Rukavina, Hans-Martin Sass, Vanja Vasiljev Marchesi, Valerije Vrček, Maja Miloš, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Europe, integrative bioethics, Fritz Jahr, ecology, environment, Northern Adriatic]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The „European Bioethics in Action (EuroBioAct)” project primarily aims at:	1. completing theoretical basis for the „new European bioethics“ (by rounding-up 	research on Fritz Jahr, Ignaz Bregenzer, and other thinkers and conceiving a 	common platform with integrated ideas of modern environment science and 	ethics) and	2. applying that theoretical basis in practice (by compiling a list of „bioethical 	standards“ for settlements, containing concrete general and specific norms for 	preservation and improvement of local eco-systems – i.e., human health, animal 	and plant welfare, etc.).In the first phase of the project realisation, the participants would continue with the broadening and deepening of the theoretical basis of the „new European bioethics“ primarily by completing the research of the life and work of Fritz Jahr and his most important models (Ignaz Bregenzer and others). In the second phase of the project, three focused workshops would be organised determining the status of the general and special ecological needs for the three local communities (Plomin, Bakar, and Mali Lošinj) from the Northern Adriatic region. The three communities selected to host the workshops have either been recently experiencing ecological threats (Plomin – thermo-electric power plant; Bakar – cokery), or represent a highly-valuable and vulnerable natural insular pocket (Mali Lošinj – health tourism, dolphin wildlife refuge, fragrant gardens programme, etc.). Based on the theoretical background and the insights provided by the workshops, in the third phase of the project, created would be the „bioethical standards“, that is, a set of principles and measures of the correct relation of men toward their own health, animals, plants, and the eco-system in total. A „bioethical standards“ charter might improve the level of local community environmental consciousness, and provide direction lines for its sustainable development (including a potential tourism-advertising ace card).]]></summary_en></project><project>
<id>2353</id><title_hr><![CDATA[Znanstveno brendiranje svinjskog mesa]]></title_hr><title_en><![CDATA[Scientifically Branded Pork]]></title_en><user_id>1296</user_id><user_firstLast_name>Goran Kušec</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-3396</code><acronim><![CDATA[SciBra Pork]]></acronim><duration>01.07.2014 - 30.06.2018</duration><status>Završio</status><financ_value>112.718,49 eur</financ_value><scie_area_hr>Biotehničke znanosti, Prirodne znanosti, </scie_area_hr><scie_area_en>Biotechnical sciences, Natural sciences, </scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Fakultet agrobiotehničkih znanosti Osijek]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Agrobiotechnical Sciences in Osijek]]></institution_en><team_members_id>2738, 6830, 4653, 7523, 1230, 7603, 7607, 7608, 3831, 19548, 21307, 13307, 13691, 20761, </team_members_id><team_members_names><![CDATA[Boris Lukić, Vladimir Margeta, Kristina Budimir, Snježana Džijan, Zinka Bošnjak, Ivona Durkin, MARINA  KRVAVICA, MARKO  JELIĆ, Kristian Sabo, Miodrag Komlenić, Mane Medić, Ivan Kelić, Zdravko  Tolušić, Polonca Margeta, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[indigenous pig breed, genomic identification, growth characteristics, carcass and meat quality, sensory traits, meat products, branding]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Black Slavonian pig is an autochthonous pig breed, established at the end of the 19th century near Osijek in eastern Croatia. The breed is black in color, resistant and convenient for keeping in extensive and half-extensive conditions. It is also characterized by good meat quality, suitable for producing typical traditional meat products. Recently, the traditionally produced food came into the focus which led to more often use of geographical indications (protected designation of origin-PDO, protected geographical indication-PGI and Traditional Specialties Guaranteed-TSG) as the valuable rural development strategy. Since Black Slavonian pig is a late maturing breed characterized by low lean meat percentage, meat processors tend to use the meat of modern pig breeds in production of traditional products. Therefore there is a need for scientifically developed methods in order to trace the origin of materials used in such production. First of all, molecular identification of breed will be performed by the use of MC1R gene and 18 microsatelite primers . Since the genotype, age and sex are possible sources of variation of the meat quality traits in pigs, the objective of proposed research is to determine the optimal time for slaughter with respect to these factors. The genetic influence on meat quality traits is nowadays well described by the use of molecular markers by which many of the candidate genes were discovered. In proposed research a special interest will be placed at some of them such as IGF2, MC4R, H-FABP3 and LEPR. The investigation of sensory traits and chemical analysis of meat and meat products will help to determine the typical physico-chemical characteristics and sensory profile of autochthonic Slavonian dry-cured meat products and fresh meat originated from Black Slavonian Pig meat. At the end, obtained polymorphisms at the microsatellite loci will be tested in identification of the origin of meat used in the production of traditional meat products.]]></summary_en></project><project>
<id>2360</id><title_hr><![CDATA[Razvoj formulacija novih prirodnih insekticida na osnovi inertnih prašiva i botaničkih insekticida i njihovih kombinacija kao zamjena za sintetske konvencionalne insekticide]]></title_hr><title_en><![CDATA[Development of new natural insecticide formulations based on inert dusts and botanicals to replace synthetic, conventional insecticides ]]></title_en><user_id>4063</user_id><user_firstLast_name>Vlatka Rozman</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-5570</code><acronim><![CDATA[DIACROMIXPEST]]></acronim><duration>01.07.2014 - 30.06.2017</duration><status>Završio</status><financ_value>95.557,05 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Fakultet agrobiotehničkih znanosti Osijek]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Agrobiotechnical Sciences in Osijek]]></institution_en><team_members_id>4202, 4081, 4365, 4414, 4277, 5109, </team_members_id><team_members_names><![CDATA[Zlatko Korunic, Josip Halamić, Anita Liška, Pavo Lucić, Ines Galović, Renata Baličević, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[natural insecticides, inert dusts, botanical insecticides, stored pest, stored products]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Croatia has a low tolerance for detectable insects in stored grain so stored pests must be controlled. The conventional choice, organosphosphates and pyrethroids, has many disadvantages due to considerable hazard of harmful residues, high cost, and the possible and already present appearance of insect resistance. The possible alternative, diatomaceous earth (DE), because of the needs to use high concentrations to control insects, is hindered by its effect on grain flow, bulk density and very high cost. Therefore, there is a great need for the development of a new, less toxic and less dangerous insecticide(s) to control insect pests of stored food and in Public Health/Pest Control field. Synergism of DE and botanicals allows effective control with much lower concentrations of active ingredients, in comparison when these components are used separately. The mode of action is a synergistic combination of desiccation, poisoning and (probably) starvation. Croatia has several sources of DE that are still not in use. These DEs have a potential to be used as natural insecticides or combining it with other natural substances to develop safe, effective and natural insecticide. Also, Croatia has a botanical diversity of indigenous plants. However, the country has not yet benefited from this wealth of knowledge on the use of plants as pesticides. These results make us confident that there is a possibility to develop the new natural synergized insecticide formulation(s) using Croatian DE and plant extract. The proposed project fits the goals and strategic priorities CSF because it encourages the international competitiveness of research groups,developing scientific field that provides the technological advances applicable to agriculture, food industry, public health, communal hygiene and veterinary medicine as well as the ability to obtain new Croatian natural products.]]></summary_en></project><project>
<id>2361</id><title_hr><![CDATA[Prospektivno biopsihosocijalno istraživanje utjecaja seksualno eksplicitnih materijala na socijalizaciju i zdravlje mladih]]></title_hr><title_en><![CDATA[Prospective Biopsychosocial Study of the Effects of Sexually Explicit Material on Young People&#39;s Sexual Socialization and Health]]></title_en><user_id>5817</user_id><user_firstLast_name>Aleksandar Štulhofer</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-9221</code><acronim><![CDATA[PROBIOPS SEM STUDY]]></acronim><duration>01.09.2014 - 31.01.2019</duration><status>Završio</status><financ_value>59.773,14 eur</financ_value><scie_area_hr>Društvene znanosti, Biomedicina i zdravstvo, </scie_area_hr><scie_area_en>Social sciences, Biomedicine and health sciences, </scie_area_en><scie_field_hr>Sociologija, </scie_field_hr><scie_field_en>Sociology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>7228, 5502, 2880, 18914, 17799, 21385, 24320, </team_members_id><team_members_names><![CDATA[Vesna Buško, Ivan Landripet, Jadranka Knežević Ćuća, Marija Brajdić Vuković, Goran Koletić, Ksenija Klasnić, Taylor Kohut, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Prospective study, panel, young people, reproductive and sexual health, emotional intimacy, committed relationships, sexually explicit material]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Digital technology has enabled an unprecedented availability and unrestricted use of sexually explicit material (SEM). As the first experiences with SEM almost invariably precede first sexual experiences, concerns have been raised about its potential impact on young people’s sexual socialization, subsequent reproductive and sexual health outcomes, as well as motivation and capacity for building and maintaining relationship intimacy. The field of socio-behavioural research on SEM has been marred by inability to distinguish between associations and causal links. The only available European panel study followed Dutch youth for only 12 months. To enable a more robust assessment of the links between SEM use and sexual socialization, health, and intimacy we propose to set up a 3-year panel sample with over 1,000 high-school students. The panel would be used to carry out biological testing on males (testosterone levels from saliva) and repeated online surveying in which the genre and the frequency of SEM use would be analyzed as predictors of subsequent sexual activity (particularly, sexual risk taking), the dynamics of attitudes toward women and committed relationships. We propose to test a conceptual model in which possible SEM influences on the outcomes are influenced by T levels, personality traits, family environment, characteristics of ego-centered social network, type of SEM used, and sexual experiences. Our biopsychosocial model aims to assess the contribution of SEM use to the process of young people’s sexual socialization, while controlling for the effects of biological makeup, intrapersonal characteristics, and interpersonal and group (family, peer group, partners) social influences.The proposed project is innovative in design and analytical conceptualization. The expected outcomes should be relevant not only in scientific terms but also in the context of public policy, particularly in the area of educational and public health interventions.]]></summary_en></project><project>
<id>2366</id><title_hr><![CDATA[Optimiranje i modeliranje termalnih procesa materijala]]></title_hr><title_en><![CDATA[Optimisation and modelling of thermal processes of materials]]></title_en><user_id>1419</user_id><user_firstLast_name>Dario Iljkić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-5371</code><acronim><![CDATA[OMOTPOM]]></acronim><duration>10.10.2014 - 09.10.2018</duration><status>Završio</status><financ_value>130.068,35 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, </scie_field_hr><scie_field_en>Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Tehnički fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Engineering]]></institution_en><team_members_id>4865, 4866, 7533, 5169, 7373, 3783, 7443, 5116, 3042, 7621, 6646, 4849, 17778, 1422, 25054, </team_members_id><team_members_names><![CDATA[Nikša Čatipović, Zvonimir Dadić, Zvonimir Kolumbic, Branimir  Lela, Mauro Maretić, Hrvoje Novak, Loreta Pomenić, Domagoj Rubeša, Goran Salopek, Sunčana Smokvina Hanza, NEVEN TOMAŠIĆ, Dražen Živković, Lovro Štic, Božo Smoljan, Milenko Jokić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[materials processing, modelling, electroless plating, electroactive composites, optimisation, modelling]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Phenomena of physical processes during the thermal processes will be investigated. Methods for modeling and computer simulations of thermal processes of materials will be developed. Thermal processes, such as, heat treating processes of steel, hot pressing of powder metals and casting of alloys of light metals will be investigate. The study of heat treatment of steel will be focused on quench hardening and tempering, and control cooling during the hot working and steel casting. Thermal stability of electro-active composites will be analyzed. Optimization of electro-less Ni-P coating of stainless steel and thermo-diffusive heat treatment of layers will be studied. Methods of optimization of application of tools and dies in thermal processing of materials will be studied. Models and computer programs for simulation of behavior steel dies during casting of light metal alloys and hot pressing of metal powders will be developed.During the thermal processes primary will be studied physical processes and material properties such as: heat transfer, microstructure transformations, mechanical properties and distortions and residual stresses. Numerical model of physical phenomena will be preferable based on finite volume method (FVM). To solve these tasks, joined thermo-mechanic-metallurgical approach will be required. The computer program for 3-D simulation of heat transfer, microstructure transformations, mechanical properties, distortions and residual stresses during the thermal processes will be developed.]]></summary_en></project><project>
<id>2368</id><title_hr><![CDATA[Dalmacija kao odredište europskog Grand Toura u 18. i 19. stoljeću]]></title_hr><title_en><![CDATA[DALMATIA - A DESTINATION OF  EUROPEAN GRAND TOUR IN 18th AND 19th  CENTURY]]></title_en><user_id>3905</user_id><user_firstLast_name>Ana Šverko</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2013-11</proposal_call><code>UIP-2013-11-7091</code><acronim><![CDATA[GRANDTOURDALMATIA]]></acronim><duration>01.07.2014 - 30.06.2017</duration><status>Završio</status><financ_value>39.219,59 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Povijest umjetnosti, </scie_field_hr><scie_field_en>Art history, </scie_field_en><institution_hr><![CDATA[Institut za povijest umjetnosti]]></institution_hr><institution_en><![CDATA[Institute of Art History, Zagreb]]></institution_en><team_members_id>5566, 4910, 3716, 5027, 5171, 5083, </team_members_id><team_members_names><![CDATA[Ivica Covic, Irena Kraševac, Ivana Vlaić, Cvijeta Pavlović, Josip Vrandečić, Iva Raič Stojanović, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Grand Tour, Dalmatia, Neoclassicism and Romanticism, Representation of Place, Contemporary Urbanscape]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Grand Tour – an exceptional journey which reached its peak in the 18th C, thoroughly changed human perception of nature and society. From the 18 to the 19th C the revolution in natural, human and technical sciences marks the beginning of modern society and contemporary approach in arts and architecture.Although Grand Tour originally focused on Rome, the exploration of  the Ancient World as the origin of Neolassicism widened its travelling radius onto further parts of the Roman Empire, among which Dalmatia held a prominent position. Drawings and literary works by travel artists and writers from that period are treasured in prestigious European museums and libraries and together constitute a priceless  portion of European cultural heritage.For the first time, all known travelogues and drawings about Dalmatia from that period will be collected, analysed and evaluated in terms of literary theory and theory of architecture. The overall aim of the project is to identify, problematise and integrate the issues related to the phenomenon of recording the space, predominantly in Dalmatia. The specific goals of the project are: establishing a working group of young researchers; raising issues of international relevance related to description of Dalmatian space based on works of the 18th and  19th C artists and writers; advancing the development of research methodology; making applicable the research of contemporary cultural-spatial context for critical rethinking in contemporary approach to architecture; creating a platform for further research at international level; establishing a dissemination channel towards both European scientific circles and wider audience.In three years of research the following will be realised: the research of archival records; field research; project webpage; three international workshops; international scientific  conference; public lectures; scientific papers and on-line proceeding book of workshops and conference.]]></summary_en></project><project>
<id>2369</id><title_hr><![CDATA[Očuvanje mikrobne raznolikosti povezane s proizvodnjom tradicionalnih hrvatskih kobasica od mesa  divljači: biotehnološka i sigurnosna karakterizacija]]></title_hr><title_en><![CDATA[Conservation of microbial diversity associated with the production of Croatian traditional game meat sausages: biotechnological and safety characterization]]></title_en><user_id>4884</user_id><user_firstLast_name>Mirna Mrkonjić Fuka</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2013-11</proposal_call><code>UIP-2013-11-6640</code><acronim><![CDATA[miCROgame]]></acronim><duration>01.10.2014 - 30.09.2017</duration><status>Završio</status><financ_value>112.149,23 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Agronomski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Agriculture]]></institution_en><team_members_id>4971, 5628, 17813, 19027, 20375, 20430, </team_members_id><team_members_names><![CDATA[Ivica Kos, Schloter Michael, Ana Žgomba Maksimović, Nataša Hulak, Irina Tanuwidjaja, Blaz Stres, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[traditional game meat sausages, lactic acid bacteria, foodborn pathogens, antibiotic resistance, starter cultures]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Despite the fact that nowadays the utilization of starter cultures is a prerequisite for the meat industry, as product reproducibility, reduction of fermentation times and enhancement of organoleptic characteristics is achieved, small scale producers in Croatia still produce spontaneously fermented game meat sausages as they still surpass in sensorial properties. Such artisan products are increasingly appreciated because of their authenticity although of great consideration due to their variable microbiological and organoleptic quality. Overall monitoring of wildlife reservoir is needed in assessment its potential as sources for zoonosis agents exposures of humans as well as sources of bacterial strains relevant for enhancement and standardization of game meat sausages production. There are large variations in prevalence of microbial populations of game meat even within a single country and the published data for Croatia is limited and poorly documented which does not allow any related analysis. Especially the data on risk -based monitoring of zoonosis and antibiotic resistance genes transmission via game meat food chain in Croatia is missing and there is not authentic collection of indigenous bacterial strains that could act as a pool of novel genes and metabolic pathways relevant for high quality food production. MiCROgame focuses on the in situ diversity analysis as well as detailed characterization of lactic acid bacteria (LAB) isolated from traditional Croatian game meat sausages. Application of this autochthonous microbiota into the sausages production can influence the end-product quality and can accelerate maturation such helping producers to be more competitive on national or EU market. Special focus will be set towards identification and characterization of potential spoilage and pathogenic microflora and antibiotic resistance traits in order to estimate safety of locally produced game meat food and to identify sources of contamination. ]]></summary_en></project><project>
<id>2374</id><title_hr><![CDATA[Reforma računovodstva i financijskog izvještavanja kao sredstvo jačanja razvoja učinkovitog financijskog upravljanja u javnom sektoru RH]]></title_hr><title_en><![CDATA[Accounting and financial reporting reform as a means for strengthening the development of efficient public sector financial management in Croatia]]></title_en><user_id>7294</user_id><user_firstLast_name>VESNA  VAŠIČEK</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-8509</code><acronim><![CDATA[ACCFORPSFMINCRO]]></acronim><duration>20.08.2014 - 30.09.2018</duration><status>Završio</status><financ_value>55.443,06 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, </scie_field_hr><scie_field_en>Economy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Ekonomski fakultet u Zagrebu]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Economics and Business]]></institution_en><team_members_id>7069, 7230, 7334, 7095, 7182, 7212, 7096, 7104, 2956, 19004, 19001, </team_members_id><team_members_names><![CDATA[Nives Botica Redmayne, SANJA BROZ TOMINAC, Verica Budimir, MARTINA DRAGIJA, Ivana Dražić Lutilsky, Maja Letica, MILENA PERŠIĆ, GORANA ROJE, Davor Vašiček, Tatjana  Jovanović, Jelena Poljasevic, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Croatia, EU, public sector, accounting, financial reporting, accounting basis, IPSAS, financial management, asset management, cost management]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The subject of the research addresses the need and ability to pursue budgetary accounting reform in Croatia, implying accrual accounting basis and International public sector accounting standards (IPSAS) implementation, with the aim to create quality accounting/financial reporting systems and sound financial management. Supporting that budgetary accounting reforms in Croatia are set as a necessity that arises from adjustments to comply with the EU regulations and the need for setting accounting system development in function of increasing the quality of accounting information as a basis for public management decision making, our research objectives broadly focus on: examining the possibilities for accruals and IPSAS appliance in Croatia, creation of public sector accounting (PSA) terminology framework, exploring the role of accounting in public sector asset management, examining the development of internal reporting system in the function of management decision making.Research objectives will be fulfilled through different activities, i.e.: exploring the adequacy of existing modified accrual basis model appliance and budgetary users’ financial statements qualitative characteristics comparison to the accruals appliance in chosen segments of the Croatian public sector; examining the level of Croatian budgetary accounting compliance with IPSAS on the path of international comparative studies on PSA harmonisation that would foster the creation of Croatian PSA terminology and interpretation on application of a selected number of IPSAS  in Croatian PSA content; developing the methodology for a comprehensive government asset recording in central asset register and whole government balance sheet; empirically assessing accounting information system from the standpoint of its’ upgrading with managerial and cost accounting elements, by developing and testing the applicable internal reporting model resulting in providing sound information for public management decision making. ]]></summary_en></project><project>
<id>2379</id><title_hr><![CDATA[Tekstilne antene za pametno okruženje]]></title_hr><title_en><![CDATA[Textile Antennas for Smart Environment]]></title_en><user_id>6555</user_id><user_firstLast_name>Davor Bonefačić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-6198</code><acronim><![CDATA[TexASE]]></acronim><duration>01.09.2014 - 31.08.2018</duration><status>Završio</status><financ_value>131.130,13 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>6808, 6535, 4646, 5165, </team_members_id><team_members_names><![CDATA[Juraj Bartolić, Radovan Zentner, Željko Penava, Branimir Ivšić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[antenna, textile antenna, wearable antenna, on-body communications, body-centric communications]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The smart environment consists of wired and wireless network of communication devices and sensors which communicate between themselves and with humans, and enable safer, more pleasant and energy efficient environment adaptable to the change of conditions and tasks. Any wireless device needs an antenna as the interface between the electronic circuits and the free space. Wireless communication modules, sensors and RFID devices are integrated in common objects like clothes, home appliances, toys, consumables, etc. The used antennas must be small and unobtrusive, yet energy efficient. The aim of this project is to investigate new materials and techniques for antenna fabrication including conductive textiles and threads. A textile antenna integrated into clothes must be lightweight, flexible, and comfortable to wear, but still must keep good radiation properties. Textile antennas are very interesting for military personnel on the field as well as for rescue teams. Another important application is healthcare, where wireless sensors in real time monitor the patients&#39; health status and transmit data to the medical personnel. The broadest field of application of wearable antennas is in the entertainment and consumer electronics and mobile communications. Energy harvesting, and with it the associated antennas, can be used in all these fields to increase energy efficiency and enable operation of mobile devices. The aim of this project is to propose new and adapt existing antenna designs for integration into clothing and for new manufacturing techniques like embroidering or weaving. Another aspect to be considered in connection with wearable antennas is their operation in the proximity of human body which is a lossy dielectric. The second aim of this project is to study both theoretically and experimentally the propagation channel on the surface of the human body and off-body communications. The results will allow designing reliable on-body and off-body communication systems. ]]></summary_en></project><project>
<id>2381</id><title_hr><![CDATA[Utjecaj procesnih parametara na kinetiku heterogenih sustava koji se odvijaju u šaržnom reaktoru s miješanjem]]></title_hr><title_en><![CDATA[Impact of processing conditions on kinetics of heterogeneous systems in agitated batch reactors]]></title_en><user_id>422</user_id><user_firstLast_name>Nenad Kuzmanić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-8959</code><acronim><![CDATA[HETMIX]]></acronim><duration>01.09.2014 - 31.08.2018</duration><status>Završio</status><financ_value>122.748,69 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Kemijsko inženjerstvo, </scie_field_hr><scie_field_en>Chemical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Kemijsko-tehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Chemistry and Technology]]></institution_en><team_members_id>6051, 3364, 6053, 4537, 6047, </team_members_id><team_members_names><![CDATA[Davor Rušić, Sandra Svilović, Marija Ćosić, Renato Stipišić, Antonija Kaćunić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[heterogeneous process, batch reactor, process parameters, mixing, kinetics, crystallization, ion exchange, heavy metals, mathematical modeling]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[From engineering point of view, heterogeneous system can be categorized as very complex. The presence of multiple phases causes a series of limitations, primarily connected to transport phenomena and actually those limitations are the ones that cause their distinct kinetic determination. Due to the complexity and the wide range of heterogeneous processes, research would be limited to solid-liquid systems, taking place in agitated batch reactors. Two heterogeneous processes are to be investigated simultaneously, one that includes and one that excludes a chemical reaction (a. Batch cooling crystallization; b. Ion exchange of heavy metals). The base intention of the proposed project is to find a link between process parameters, hydrodynamic conditions in agitated batch reactor, process kinetics and characteristics of the final product (that is, final process result). Furthermore, the intention is to examine the mentioned relation as a function of reactor scale size as well. Considering the kinetic determination of the process, special attention will be given to the investigation of the influence of hydrodynamic conditions, i.e. the influence of the mixing operation in a batch reactor on the kinetics of the investigated processes. Since one of the goals of this project is to contribute to the theory of reactor design, experimentally obtained insights could represent the criteria basis of heterogeneous solid-liquid process equipment scale up as well as the basis for the mathematical modeling of the impact of operating conditions on the heterogeneous process result. This way the functional relations between studied variables would be established. ]]></summary_en></project><project>
<id>2384</id><title_hr><![CDATA[Višeskalni model betona s identifikacijom parametara]]></title_hr><title_en><![CDATA[Multi-scale concrete model with parameter identification]]></title_en><user_id>4072</user_id><user_firstLast_name>Ivica Kožar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-9068</code><acronim><![CDATA[ConcreteMuScID]]></acronim><duration>01.09.2014 - 31.08.2018</duration><status>Završio</status><financ_value>128.741,12 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Građevinarstvo, </scie_field_hr><scie_field_en>Civil engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Građevinski fakultet u Rijeci]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Civil Engineering]]></institution_en><team_members_id>4673, 4880, 5624, 6013, 6135, 6912, 6843, 17853, </team_members_id><team_members_names><![CDATA[Gojko Balabanić, Joško Ožbolt, Boris Podobnik, Neira Torić Malić, Silvija Mrakovčić, Natalija Bede, Anamarija Perušić, Tea Rukavina, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[multi-scale, concrete, system identification, dynamic loading, computer model]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[In complex numerical models the calibration can only be achieved through interaction of measured data with the underlying mathematical model. Especially difficult situation occurs when loading is stochastic (e.g. wind, earthquake, traffic) since there is no direct relation between loading (input) and displacements (output).	System parameter identification will be based on inverse mathematical formulation so to present a reliable and theoretically sound procedure for identification of required parameters. One of the main goals of the system identification procedure is representative volume identification. It will be necessary to consider non-Gaussian stochastic processes with heavy tails characterizing dangerous rare events.	Regarding material parameters this project advocates the hypothesis that the fracture energy of a material is approximately constant and that the material constitutive law should not incorporate “rate effect”. The idea of (approximately) constant fracture energy for all loading rates is new and important in models of concrete under the dynamic loading. Also, the inclusion of the viscous parameter in the existing 3D microplane model for concrete is of vital importance for fatigue analysis since it connects creep and shrinkage (internal material loading) with dynamic loading (external structural loading).	In the end the developed concrete model will account for corrosion by coupling the mechanical properties of concrete and properties affecting the transport of humidity, oxygen and  chloride (chemo-hygro-thermo-mechanical model).	The calibration of the 3D model and its verification will be performed based on the simulation of the corresponding experimental tests from the laboratory and the available literature according to the procedure for system parameter identification described above.	Two main characteristics of the project: highly applicative and at the same time capable of producing high impact scientific results.]]></summary_en></project><project>
<id>2399</id><title_hr><![CDATA[Sekundarno stanovanje i socijalna održivost lokalnih zajednica u Hrvatskoj]]></title_hr><title_en><![CDATA[Second Homes and Social Sustainability of Local Communities in Croatia]]></title_en><user_id>6867</user_id><user_firstLast_name>Geran-Marko Miletić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2013-11</proposal_call><code>UIP-2013-11-1875</code><acronim><![CDATA[SHSSLCC]]></acronim><duration>01.06.2014 - 15.09.2017</duration><status>Završio</status><financ_value>32.751,68 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Sociologija, </scie_field_hr><scie_field_en>Sociology, </scie_field_en><institution_hr><![CDATA[Institut društvenih znanosti Ivo Pilar]]></institution_hr><institution_en><![CDATA[Institute of Social Sciences Ivo Pilar in Zagreb]]></institution_en><team_members_id>6323, 6317, 2541, 5688, 6024, 1220, 6746, 6092, 6603, 18985, 18979, 18980, 18981, 18982, 18983, 18984, </team_members_id><team_members_names><![CDATA[Anka Mišetić, Roko Mišetić, Krešimir Peračković, Saša Poljanec-Borić, Tomislav Smerić, Nenad Pokos, Sara Ursic, Mario Bara, Marica Marinović Golubić, Rašeljka Krnić, Srđana Urlić, Stanko Mirošević, Duje Radovniković, Mirjana Urlić, Katarina Mirošević, Boris Bučević, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[second homes, social sustainability, local communities, leisure, Croatia]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The planned project starts from the premise that second home use, i.e. occasional use of dwellings for vacation and recreation, is a strong factor in socio-spatial transformation. There is a constant growth of this trend in Croatia, whereby certain areas, or to be more precise, the coastal area is more exposed to second homes expansion. This increase in pressure of second homes and the tendency of this phenomenon to change and take new forms, especially under the influence of the expected growth of international second homes and disappearance of the hierarchy in the use of dwellings, have directed the planned project towards one question: are second homes only an obstacle, or could they be a source of opportunities, i.e. an additional impulse to the social sustainability of local communities in Croatia. The main objectives of the project are: 1) Identifying settlements in Croatia with an increased number of second homes; 2) Determining types of settlements in Croatia, and getting an insight into the connection of second homes to relevant sociodemographic and socioeconomic features of the settlers; and 3) Analysing how second homes affect the daily life of the local community, social structures and processes in it. These objectives direct the research towards combining secondary analysis of the census data and the analysis of the empirical data gathered through case studies. This will enable a deep insight into the way second homes affect the local social reality. ]]></summary_en></project><project>
<id>2402</id><title_hr><![CDATA[Pretvorba ostataka poljoprivredne proizvodnje i energetskih kultura u energiju i proizvode dodane vrijednosti – proizvodnja bioulja i biougljena]]></title_hr><title_en><![CDATA[Converting waste agricultural biomass and dedicated crops into energy and added value products – bio-oil and biochar production]]></title_en><user_id>5589</user_id><user_firstLast_name>Tajana Krička</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-3328</code><acronim><![CDATA[AgBiomassConversion]]></acronim><duration>15.10.2014 - 14.10.2018</duration><status>Završio</status><financ_value>104.269,69 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Agronomski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Agriculture]]></institution_en><team_members_id>5606, 5600, 5604, 5608, 19075, 19643, </team_members_id><team_members_names><![CDATA[Neven Voća, Vanja Jurišić, Ana Matin, Nikola Bilandžija, Alan Antonović, Mateja Grubor, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[waste agricultural biomass, dedicated crops, conversion, pyrolysis, energy, added value products, bio-oil, biochar]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Biomass is one of the promising renewable energy resources and can be a partial alternate to fossil fuels. Common methods applied to make use of biomass energy potential are biochemical and thermochemical conversion methods. Pyrolysis is a thermo-chemical process carried out in the absence of oxygen that yields with three different end-products – bio-oil, biochar and syngas. Pyrolysis of agricultural residues can help meet renewable energy targets by displacing fossil fuels and, thereby, deal with concerns regarding the global warming. Unlike direct combustion, pyrolysis yields with more end-products. Bio-oil has environmental benefits as a clean fuel and causes less pollution as compared to fossil fuels, whereas biochar can be put on soil and act as a carbon-sequestering and climate-mitigating agent. Based on the above-mentioned, the overall objective of this project is to determine the potential of different types of biomass residues and waste, and dedicated crops, for bio-oil and biochar production via pyrolysis. Since the type of feedstock significantly influences the pyrolysis process and the yield of end-products, the specific objective of the proposed project will be to determine the potential of pyrolysis from different biomass feedstock collected in two climatically different regions, Mediterranean and Continental Croatia. Project will be split into three main phases, including feedstock collection and characterization, biomass pyrolysis, and end-products&#39; (bio-oil and biochar) characterization. This will provide the most detailed database so far, speaking worldwide, and should result with the information on the optimum feedstock, concerning the available biomass in relation to the region.]]></summary_en></project><project>
<id>2409</id><title_hr><![CDATA[Porezna politika i fiskalna konsolidacija u Hrvatskoj]]></title_hr><title_en><![CDATA[Tax Policy and Fiscal Consolidation in Croatia]]></title_en><user_id>82</user_id><user_firstLast_name>Helena Blažić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-8174</code><acronim><![CDATA[TPFCC]]></acronim><duration>01.06.2014 - 30.06.2018</duration><status>Završio</status><financ_value>36.827,92 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, </scie_field_hr><scie_field_en>Economy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Ekonomski fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Economics and Business]]></institution_en><team_members_id>2759, 2716, 2754, 3265, 1250, 2822, 3555, 3370, 6318, 6361, 5230, </team_members_id><team_members_names><![CDATA[Maja Grdinić, Ana  Grdović Gnip, Maja Klun, Hrvoje Šimović, Ana Štambuk, Lejla Lazovic-Pita, Milan  Deskar-Škrbić, Bojana Olgić Draženović, Žiga Kotnik, Saša Drezgić, Mario  Pečarić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[tax policy, tax system, tax structure, fiscal consolidation, Croatia]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The project is dealing with a tax policy problem Croatia has been tackling with in times of its fiscal consolidation as to ensure enough fiscal revenues, support long-term growth and maintain and even increase the equity of the tax system. The research starts with an extensive expert opinion survey about the state and perspectives of Croatian tax systems, which will be extended to Slovenia and Bosnia and Herzegovina in order to do relevant cross analysis of the obtained results. This survey will be followed by some public attitude surveys concerning relevant tax issues.The macroeconomic effects of fiscal consolidation measures in Croatia, with the emphasis on tax measures, will be analyzed at different government levels as well as the effects of tax structure on the economic growth. The research will be broadened to encompass other (mostly region) countries.It is expected that the research team with their in-depth tax policy analyses will pinpoint different aspects of crucial tax policy issues in Croatia with problem-solving recommendations regarding financial transaction tax, real estate tax, environmental taxation, flat tax and some other base broadening and tax expenditure issues. ]]></summary_en></project><project>
<id>2414</id><title_hr><![CDATA[Likovna umjetnost i komunikacija moći u razdoblju ranoga novoga vijeka (1450.-1800.) : povijesne hrvatske regije na razmeđi Srednje Europe i Mediterana]]></title_hr><title_en><![CDATA[Visual Arts and Communication of Power in the Early Modern Period (1450-1800): Historical Croatian Regions at the Crossroads of Central Europe and the Mediterranean]]></title_en><user_id>1226</user_id><user_firstLast_name>Milan Pelc</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-6827</code><acronim><![CDATA[VACOP]]></acronim><duration>01.07.2014 - 30.06.2018</duration><status>Završio</status><financ_value>66.218,73 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Povijest umjetnosti, </scie_field_hr><scie_field_en>Art history, </scie_field_en><institution_hr><![CDATA[Institut za povijest umjetnosti]]></institution_hr><institution_en><![CDATA[Institute of Art History, Zagreb]]></institution_en><team_members_id>6665, 4903, 3408, 3742, 3481, 4586, 4663, </team_members_id><team_members_names><![CDATA[Josip Belamarić, Višnja Bralić, Daniel Premerl, Ivana Prijatelj Pavičić, Mirjana Repanić-Braun, Petra Batelja, Maja Žvorc, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Art, Politics, Communication, Croatia, Early Modern period]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[This research will primarily focus on the analysis andinterpretation of the relation of pow er holders tow ard the visualarts in Croatian regions of the Early Modern Period, as w ell asthe places and the media of their transmission. In the spirit ofnew art history, the research w ill seek to answ er the follow ingquestions: 1. w hich media channels – including communicationmeans and strategies – did certain centres of pow er use tocreate and promote favourable responses among differenttypes of recipients in Croatia of the early modern period? 2.w hat w as the role of visual art in shaping public opinion and thesocial promotion and re(presentation) of pow er holders? Thepow er holders in Croatian regions w ho acted as artcommissioners w ere primarily from the ranks of the aristocracy(both secular and ecclesiastical) – representatives of the stateideologies of the Venetian Republic, the Kingdom of Hungary,the Habsburg Monarchy and the Dubrovnik Republic. In additionto them, there w ere also local corporate patrons and artcommissioners – confraternities – w hich mainly reflected theinterests of local communities. Those art commissioningchannels made possible cultural transfers in visual arts andarchitecture in the Croatian territory during the period from theearly Renaissance to the late Baroque. The research w illfacilitate the creation of a database containing relevant visualrecords of the aforementioned historical period, w hich w illenable a comparative analysis of the phenomenon from theperspective of the sociology of culture, critical iconology andsemiotics. Finally, this w ill result in the development of anappropriate model for the understanding and interpretation ofthe specific usage of visual arts as mediator in thecommunication of pow er in Croatia of 1450-1800.]]></summary_en></project><project>
<id>2420</id><title_hr><![CDATA[Novi koncept primijenjene kognitivne robotike u kliničkoj neuroznanosti]]></title_hr><title_en><![CDATA[A new concept of Applied Cognitive RObotics in clinical Neuroscience]]></title_en><user_id>7302</user_id><user_firstLast_name>Bojan Jerbić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-4192</code><acronim><![CDATA[ACRON]]></acronim><duration>01.09.2014 - 31.08.2018</duration><status>Završio</status><financ_value>124.228,55 eur</financ_value><scie_area_hr>Tehničke znanosti, Biomedicina i zdravstvo, </scie_area_hr><scie_area_en>Technological sciences, Biomedicine and health sciences, </scie_area_en><scie_field_hr>Strojarstvo, </scie_field_hr><scie_field_en>Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>7303, 3760, 7444, 7454, 7453, 7448, 7450, 7555, 7311, 7582, 7611, 17378, 22645, </team_members_id><team_members_names><![CDATA[Darko Chudy, Gojko Nikolić, Tomislav Stipančić, Filip  Šuligoj, Petar Ćurković, Marko Švaco, Bojan Šekoranja, vedran deletis, Dominik Romić, Gordan Grahovac, Domagoj Dlaka, Vladimira Vuletic, Josip Vidaković, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[robotics, artificial intelligence, cognitive models, medicine, neuroscience]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The research in this project leads to novel forms and uses of cognitive robotics applied in clinical neuroscience. Robot’s performances during the surgical procedures are investigated within the previously conducted technological project, RONNA - Robotic Neurosurgical Navigation. Results of RONNA suggest that the benefits of using robots in the operating room are enormous, e.g. increased accuracy and repeatability of the surgical procedures, flexible and tremor free operations, etc. During the RONNA realisation, it is recognized that certain new cognitive robot skills yet need to be developed.The long-term vision of the proposed ACRON project as a multi-disciplinary research arises from the recognition that a paradigm shift in human-robot-environment interaction is needed. Currently, technology robustness is achieved by restricting the interaction space, so that the region and the nature of the interaction can be controlled by the system. In ACRON, the cognitive fulcrum will therefore move from sensed data to the robot contextual anticipation.ACRON will advance the research providing a uniform scientific framework for the study, development and implementation of cognitive concepts, providing the robot to function in ICT enabled ubiquitous environment that can be shared by different kinds of agents. ACRON will therefore bring the new context-aware medical robot capable to anticipate the most appropriate actions respecting the phase of the medical procedure and spatial positions of the staff and objects. We will investigate the relationship between people, robots and the shared environment where they interact and work together. By moving throughout the discretized working space and while achieving the current assignment, the medical robot will become able to avoid all-possible spatial collisions and make the appropriate context-based decisions.]]></summary_en></project><project>
<id>2432</id><title_hr><![CDATA[Uspostavni istraživački projekti o društvenom poduzetništvu]]></title_hr><title_en><![CDATA[Installation Project for REsearch about Social ENTrepreneurship]]></title_en><user_id>4514</user_id><user_firstLast_name>dražen šimleša</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2013-11</proposal_call><code>UIP-2013-11-5332</code><acronim><![CDATA[iPRESENT]]></acronim><duration>15.09.2014 - 01.03.2018</duration><status>Završio</status><financ_value>49.880,38 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Sociologija, </scie_field_hr><scie_field_en>Sociology, </scie_field_en><institution_hr><![CDATA[Institut društvenih znanosti Ivo Pilar]]></institution_hr><institution_en><![CDATA[Institute of Social Sciences Ivo Pilar in Zagreb]]></institution_en><team_members_id>6323, 4720, 7578, 21224, </team_members_id><team_members_names><![CDATA[Anka Mišetić, Filip Majetić, Jelena Puđak, Anita Bušljeta Tonković, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[social entrepreneurship, sustainability, social benefits, responsible, business model]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The main goal of iPRESENT (Installation Project for REsearch about Social ENTrepreneurship) project is to research capacities and potentials of social entrepreneurship as an environmentally friendly and socially responsible business model in Croatia. Social Entrepreneurship is one of the leading and growing phenomena, it has outcomes in social, economic and environmental fields, and as such is suitable and studious for scientific research. This is especially the case in a country such as Croatia, with longstanding economic crisis, rise of unemployment; decrease of social rights and trust, but at the same time quite a wealth of natural resources and tradition in cooperative business models. The project has a specific objective to initiate and secure long term scientific base and data for research on social entrepreneurship in Croatia; to set up a relevant and up to date published materials about social entrepreneurship open to science community and public; to test the level of 3BL (Triple bottom line) in social enterprises in Croatia; and to prepare guidelines and “advice book” for potential social entrepreneurs and recommendations for important and interested stakeholders. Through the three years of project duration, an already experienced scientist and researchers with young colleagues will explore and define the concept of social entrepreneurship, compare and elaborate EU perspectives and conditions regarding the subject of the project, but also place considerable emphasis on methodological approach that should provide us with reliable and operable scientific data. The project consists of a balanced and well suited mix of qualitative and quantitative scientific methods depending on applicability and specific needs within the project.It is worth mentioning that this is the first time in Croatia that the scientific community recognised social entrepreneurship as a valuable subject for long-term analytical work and research.]]></summary_en></project><project>
<id>2441</id><title_hr><![CDATA[Mjerenje, modliranje i prognoziranje volatilnosti]]></title_hr><title_en><![CDATA[Volatility measurement, modelling and forecasting]]></title_en><user_id>7589</user_id><user_firstLast_name>Josip Arnerić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2013-11</proposal_call><code>UIP-2013-11-5199</code><acronim><![CDATA[Volatility]]></acronim><duration>01.09.2014 - 31.08.2017</duration><status>Završio</status><financ_value>36.519,80 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, </scie_field_hr><scie_field_en>Economy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Ekonomski fakultet u Zagrebu]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Economics and Business]]></institution_en><team_members_id>3912, 4299, 4342, 6252, 4385, 4833, 21323, </team_members_id><team_members_names><![CDATA[Blanka Škrabić Perić, Mirjana Čižmešija, Tea Poklepović, Ivana Lolić, Petar Sorić, Zdravka Aljinović, Danijel Mlinarić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[OHLC volatility estimator, GARCH switching model, news impact curve, panel-GARCH models, high-frequency data, neural-networks, quasi-Newton algorithm]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Volatility of financial time series has become a key input to many important finance applications such as investment, portfolio selection and allocation, option pricing, hedging and risk management. The importance of accurate volatility estimates has become even more significant after the financial crisis. As volatility itself is not observable variable, many different volatility estimators have emerged in the literature to address this problem. This project proposal will explore some of methodologically complexities of volatility modelling and forecasting with respect to both the parametric and nonparametric approaches. Moreover, one of the objectives is to investigate news impact curve of different volatility models as well as to compare different types of Generalized Autoregressive Conditional Heteroscedascity models in terms of their ability to describe structural changes in returns and to explore if Markov regime switching GARCH models outperform uni-regime GARCH models in forecasting volatility when sudden switching occurs. According to previous commonly used aspects of volatility measurement and modelling, two relatively new approaches will be explored. First one relies on neural-networks as econometric tool. The second one combines panel methodology with GARCH models. It should be emphasized that new OHLC volatility estimator will be defined as the most efficient one when high frequency data is not available. The main contribution is to train doctoral and postdoctoral students within interdisciplinary areas of statistics, econometrics, financial econometrics, mathematics, operational research and their applications.]]></summary_en></project><project>
<id>2445</id><title_hr><![CDATA[Hijerarhijska konsolidacija velikih potrošača temeljena na upravljanju za integraciju u napredne mreže]]></title_hr><title_en><![CDATA[Control-based Hierarchical Consolidation of Large Consumers for Integration in Smart Grids]]></title_en><user_id>7612</user_id><user_firstLast_name>Mario Vašak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2013-11</proposal_call><code>UIP-2013-11-6731</code><acronim><![CDATA[3CON]]></acronim><duration>01.12.2014 - 30.11.2017</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>7616, 7618, 7624, 17458, 17455, 19265, 19325, </team_members_id><team_members_names><![CDATA[Vinko Lešić, Mato Baotić, Nedjeljko  Perić, Hrvoje  Novak, Marko Gulin, Anita Martinčević, Antonio Starčić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[optimal control, hierarchical control, building, railway traffic system, energy consumption, power flow optimisation, prosumer, smart grid]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Buildings and railway traffic systems are examples of complex technical systems that consume significant energy amounts so as to enable their inner processes to evolve as required. Thereby the requirements on dynamic functioning of these systems can be achieved by different system interactions, whereas some of them are more preferable than the others from the standpoints of energy consumption or other criteria like price of operation or equivalent pollution.The global objective of the project 3CON is to research and develop optimal control techniques on significantly different large consumers – building systems and railway traffic systems – in conceptually identical way: by applying the principle of hierarchical decomposition of systems and cooperative optimal controls between the hierarchy levels. In that way the computed energy consumption profile on the lower level directly maximizes the global economic gain of the system operation in the presence of system constraints (e.g. allowed temperatures or fixed train travelling time). This will enable the proactive role of these largest consumers in energy grids of the future (smart grids). It will make them responsive and in position to best exploit the imposed varying energy exchange terms. Thereby vast possibilities in energy grid management through dynamic pricing will be opened – foremost for reducing losses between generation and consumption points in the grid and increasing grid reliability. The secondary global objective of this installation grant is to build an internationally competent research group in control of energy-intensive systems on the Faculty which is also recognized and accepted by relevant domestic companies.The project developments will be verified through building and railway traffic case studies that will be supervised by relevant Croatian companies. This will ensure that all relevant system issues are taken care of in the design and that the design itself is close to exploitation.]]></summary_en></project><project>
<id>2446</id><title_hr><![CDATA[Infektomika humanih jetrenih neparenhimskih stanica u kroničnom hepatitisu C]]></title_hr><title_en><![CDATA[Infectomics Study of Human Liver Non-parenchymal Cells in Chronic Hepatitis C]]></title_en><user_id>6975</user_id><user_firstLast_name>Adriana Vince</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-4241</code><acronim><![CDATA[ILHNCHC]]></acronim><duration>01.07.2014 - 31.05.2019</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Ništa od navedenog]]></institution_hr><institution_en><![CDATA[Nothing from this list]]></institution_en><team_members_id>3952, 3951, 7271, 3443, 7295, 7391, </team_members_id><team_members_names><![CDATA[Lana Gorenec, Ivana Grgić, Ivan  Kurelac, Neven Papić, Davorka Dušek, Tajana Filipec Kanižaj, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[HCV, gene expression, Kupffer cells, LSEC, inflammation, immunotolerance  ]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Hepatitis C virus (HCV) is the leading cause of liver disease. HCV productively infects hepatocytes to impart liver inflammation and progressive tissue damage leading to fibrosis and cirrhosis. These processes underlie liver dysfunction and are thought to drive the onset of liver cancer. However, the molecular mechanism(s) by which HCV confers hepatic inflammation are not defined. Now, there is growing evidence that liver sinusoidal endothelial cells (LSEC) and Kupffer cells (KC), may play key roles in regulating immune responses and facilitating tolerance induction. These cells are playing a pivotal role in blood-borne virus clearance (>90%), leaving only a small fraction of infectious virus that escapes clearance in a manner peculiar to each individual pathogen. The biology of HCV, specifically regarding non-parenchymal liver cells, has been largely neglected. LSEC account for the 20% and KC for 15% of the hepatic cells, and are a unique organ-resident cell population with diverse functions, including degradation of bacterial by-products, antigen presentation and induction of tolerance. The hypothesis of the research is that HCV infection reprograms cellular gene expression of LSEC and KC, which results in the modulation of the inflammatory responses. Applying the infectomics approach, we plan to perform a series of next-generation sequencing experiments on LSEC and KC isolated and purified from healthy, mild and severe chronic hepatitis C liver biopsies. This will allow us to detect expression changes related with disease progression. Selected candidate genes will be comprehensively studied in in vitro systems in order to elucidate their role in modulation of inflammatory and adaptive immune responses. Through the development of this project it is expected that a series of high impact results will be obtained, which will facilitate the development of more significant biomarkers and effective interventions against HCV infection.]]></summary_en></project><project>
<id>2447</id><title_hr><![CDATA[Komunikacije usmjerene čovjeku u pametnim mrežama]]></title_hr><title_en><![CDATA[Human-centric Communications in Smart Networks]]></title_en><user_id>932</user_id><user_firstLast_name>Maja Matijašević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-8065</code><acronim><![CDATA[HUTS]]></acronim><duration>01.10.2014 - 30.09.2017</duration><status>Završio</status><financ_value>99.542,11 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>2717, 2626, 2628, 2612, 4930, 5079, 2706, 2572, 2770, 2775, 4895, 6720, 6608, 2785, 5345, 5033, 5339, 17866, </team_members_id><team_members_names><![CDATA[Ignac Lovrek, Igor Sunday Pandžić, Zeljka Car, Gordan Ježić, Mario Kušek, Ivana Podnar Žarko, Krešimir Pripužić, Ognjen Dobrijević, Tomislav Grgić, Mirko Sužnjević, Marin Vuković, Aleksandar Antonić, Šimo Brtan, Krunoslav Ivešić, Damjan Katušić, Nenad Markuš, Pavle Skočir, Martina Marjanović, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[smart network, big data, cloud communications, human computer interface, internet of things]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Human-centric Communications in Smart Networks (HUTS) project will address open questions regarding smart networks and human-centric communication in which data is both gathered from – and provided to – humans, anywhere and at any time, responding to their current needs. Through its research objectives, the project will investigate networking aspects of human-centric communication, such as the allocation and optimization of cloud and network resources and also providing related quality of service guarantees. This research will be used as a building block for various smart services, which enable user and device adaptation based on learning from previous situations and communicating the results of these situations. This powerful concept relies on new methods in cloud computing for big data processing and Internet-connected objects, such as smart sensors and actuators, as well machine-to-machine communication between devices using self-organizing ad-hoc networks. Smart services are further built upon innovative complex-service composition methodology and intelligent mechanisms to be formulated by the project. The introduction of smart services will drive the changes in the way people interact with devices towards more intuitive and unconstrained means. In particular, contactless user interaction, considering various categories of users, and networked virtual worlds/environments will be studied. Network data traffic models and network management will be proposed, including online charging mechanisms for dynamic pricing and cost calculation of smart services. The research proposed in this project will create new knowledge, strengthen research mentoring and improve young scientist capacities in Croatia, contribute results to science in the area of Information and Communication Technology, and help develop Croatian scientific and research space as one of the long-term strategic priorities, enabling knowledge transfer to Croatian economy for the benefit of society.]]></summary_en></project><project>
<id>2464</id><title_hr><![CDATA[Jako korelirani elektroni u slojnim organskim materijalima i manganitima: niskofrekventna pobuđenja i nelinearna dinamika]]></title_hr><title_en><![CDATA[]]></title_en><user_id>2708</user_id><user_firstLast_name>Mario Basletić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-6358</code><acronim><![CDATA[SCEinLOM]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>17776</team_members_id><team_members_names><![CDATA[ Doktorand: Branimir Mihaljević ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[correlated electrons, unconventional superconductivity, colossal magnetoresistance, charge and spin orderings, quantum spin liquids, nonlinear effects]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Strongly correlated electrons in solids generate broken symmetry phases and collective excitations that are fundamental to our understanding of the most intriguing properties of quantum matter. Phase diagrams of layered cuprate, organic superconductors and manganites, as well as some other transition-metal systems, famous for the phenomena of unconventional superconductivity (SC) and colossal magnetoresistance (CMR), respectively feature an extraordinary complexity of electronic phases, which can be tuned by chemical composition, magnetic field and pressure. A prominent place among these phases is held by stripes, patterns of charge order (CO), which are thought to be linked to SC and CMR, as well as by CO phases with ferroelectric signatures due to a rich variety of nonlinear properties and complex dynamics. Despite intense research efforts, these basic issues in condensed matter physics bear many open questions. We propose to investigate the nature of charge/spin-ordered phases and their motion developed in series of organic and transition metal solids applying modern experimental tools available at the Institute of Physics, Zagreb and at the Department of Physics, Faculty of Science, University of Zagreb (dielectric spectroscopy, pulsed nonlinear conductivity, ac/dc resistance, magnetoresistance and Hall effect).  Our overall contributions to the field and our expertise in condensed matter physics have been internationally recognized. Together with the available experimental means, this positions us as researchers fully suitable and competent for the proposed task. Our international partners will give an added value with samples, experiments and expertise in the terahertz and infrared spectroscopy. Integrated students and postdocs are going to acquire advanced skills in the materials science and learn to solve complex problems in a collaborative environment. Results will be published in international scientific journals and presented at international conferences.]]></summary_en></project><project>
<id>2465</id><title_hr><![CDATA[Liječenje neuropatske boli stimulacijom spinalnog ganglija]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4000</user_id><user_firstLast_name>Damir Sapunar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-5195</code><acronim><![CDATA[NeuroMod]]></acronim><duration>08.01.2015 - 06.02.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Split School of Medicine]]></institution_en><team_members_id>17768</team_members_id><team_members_names><![CDATA[ Doktorand: Tihana Repić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[neuropathic pain, nerve injury, neuromodulation, dorsal root ganglion, ganglionic field stimulation, T-junction, microelectrode arrays]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Neuropathic pain is a debilitating disease of the somatosensory system that has a huge socio-economic impact. Numerous studies, including those from our laboratory have established that the injured dorsal root ganglion (DRG) is the important site for pathophysiologic changes that lead to development of neuropathic pain. Although DRG neurons are critical for the onset of neuropathic pain, there are no relevant clinical treatments for neuropathic pain that target this organ. With this proposal we aim to prove that neurostimulation techniques can be successfully used to manipulate neuronal function at the level of experimentally injured DRGs. In order to test this hypothesis we will construct a fully implantable neuronal stimulator for freely moving rats, devise an implantation technique and define stimulation protocols. This stimulator will be tested in rats with two types of experimentally induced nerve injury; spinal nerve ligation and carrageenan-induced inflammation model. Since this invasive procedure bears substantial risk of inflammation and other adverse neural tissue response, which can induce pain per se, we will also investigate connective tissue fibrosis and neuroinflammatory response in neural tissue of DRG and dorsal horn. The effect of the stimulation on excitability of injured DRG neurons will also be tested in vitro. Our last aim builds on our previous study in which we showed that neuronal injury may disable T-junction filtering and thereby increase the net conduction of afferent traffic. With this proposal we will test whether stimulation can modulate filtering properties of DRG T-junction. This will be addressed using recordings from injured sensory neurons of dorsal root ganglia excised from adult rats, and recently developed methodology that will allow us to electrically visualize action potential propagation in DRG neurons grown over custom microelectrode arrays.]]></summary_en></project><project>
<id>2466</id><title_hr><![CDATA[Diofantove m-torke, eliptičke krivulje, Thueove i indeksne jednadžbe]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1262</user_id><user_firstLast_name>Alan Filipin</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-9078</code><acronim><![CDATA[DIOPHANTINE]]></acronim><duration></duration><status>Prekinut</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Građevinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Civil Engineering]]></institution_en><team_members_id>17746</team_members_id><team_members_names><![CDATA[ Doktorand: Marija Bliznac ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Diophantine equations, elliptic curves, Diophantine approximations, polynomials, cryptography]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The proposed project will coordinate and support research activities of Croatian number theory group. One of the main topics of research in this project will be Diophantine m-tuples (sets with the property that the product of its any two distinct elements increased by 1 is a perfect square) and their generalizations. The first Diophantine quadruple {1,3,8,120} was found by Fermat. Baker and Davenport proved that Fermat&#39;s set cannot be extended to a quintuple. This result motivated the famous conjecture that there does not exist a Diophantine quintuple. Dujella proved that there does not exist a Diophantine sextuple and that there are only finitely many Diophantine quintuples. Recently, Filipin, Fujita and Elsholtz significantly improved previously known upper bounds for the number of Diophantine quintuples, but the main conjecture still remains open. Various generalizations of Diophantine m-tuples will be studied, in particular, considering the problem in the rings of integers of number fields of small degree.  Diophantine triples were used by Dujella in construction of high-rank elliptic curves over Q and Q(T) and new results in that direction are expected. In determining exactly the Mordell-Weil group of several elliptic curves over Q(T), an important tool is recent algorithm by Gusić and Tadić for finding rationals at which the specialization map is injective. We plan to improve and extend this algorithm for elliptic curves over K(T) for general number fields K. Members of the group will also work on Thue, Thue-Mahler and index forms equations, problems related to sums of divisors, polynomial root separation and applications of Diophantine approximations to cryptanalysis. The results of the research will be published in respectable journals and presented on international conferences. Through this project we will intensify our scientific connections with international number-theorists and qualify young researchers for scientific research in number theory.]]></summary_en></project><project>
<id>2468</id><title_hr><![CDATA[Uloga miRNA u infekciji i patogenezi herpes simplex virusa 1]]></title_hr><title_en><![CDATA[]]></title_en><user_id>43</user_id><user_firstLast_name>Igor Jurak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-3295</code><acronim><![CDATA[]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Fakultet biotehnologije i razvoja lijekova]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Biotechnology and Drug Development]]></institution_en><team_members_id>17801</team_members_id><team_members_names><![CDATA[ Doktorand: Marina Matešić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>2470</id><title_hr><![CDATA[Algebarske i kombinatorne metode u teoriji verteks algebri]]></title_hr><title_en><![CDATA[]]></title_en><user_id>92</user_id><user_firstLast_name>Dražen Adamović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-4322</code><acronim><![CDATA[ACMVAT]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>17775</team_members_id><team_members_names><![CDATA[ Doktorand: Ana Kontrec ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[vertex algebras, W-algebras,  affine  Lie algebras, logarithmic  CFT, combinatorial bases,  Zhu&#39;s algebras, C2 cofiniteness,]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[In the proposed project we shall study the representation theory of important classes of vertex algebras with particular emphasis on the theory of vertex algebras with origins  in physics. We shall also study the affine vertex algebras and their connections with W-algebras. Based on previous research of D. Adamović and O. Perše from the papers J. Algebra 319 (2008); SIGMA 8 (2012); Algebras and Representation Theory 16 (2013) we shall apply the representation theory of vertex algebras of affine type   to the structure and representation theory of W-algebras. In the last few years, C2-cofinite, irrational vertex algebras with non-semisimple representation categories attracted a lot of interest. Such vertex algebras also appear in the logarithmic conformal field theory. By using methods developed in the papers by  D. Adamović and  A. Milas: Adv. Math. 217 (2008), Comm. Math. Phys. 288 (2009),  Adv. Math. 227 (2011)  and  J. Math. Phys. 73511 (2012) we shall study the representation theory of certain irrational, C2-cofinite vertex algebras and their connections with the theory of quantum groups. An emphasis will be put on the tensor categories of modules of C2-cofinite vertex algebras, the determination of fusion rules, orbifold vertex subalgebras and the explicit realization of logarithmic representations.  A part of the research will be devoted to some combinatorial aspects of the  representation theory of affine Kac-Moody Lie algebras. We will study  the application of intertwining operators   on the determination of   combinatorial bases of Feigin-Stoyanovsky type subspace and the associated fermionic character formulas developed by M. Primc and  collaborators. We also plan to apply the above methods on the combinatorial structures related to triplet vertex algebras and logarithmic CFT.]]></summary_en></project><project>
<id>2472</id><title_hr><![CDATA[Lokalna proba i mezoskopska dinamika u novim fazama jako koreliranih elektronskih sustava]]></title_hr><title_en><![CDATA[]]></title_en><user_id>50</user_id><user_firstLast_name>Miroslav Požek</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-9935</code><acronim><![CDATA[LOMEDY]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>17735</team_members_id><team_members_names><![CDATA[ Doktorand: Marija Došlić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[nuclear magnetic resonance, microwaves, cuprates, pnictides, frustrated spin systems, charge order]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Investigations of strongly correlated electron systems (SCES) attract an ever-growing scientific community, not only because of high potential for new technological applications, but also as a virtually unfailing source of new basic phenomena and theoretical concepts. The properties of such systems can be described only by taking into account collective phenomena governed by strong and competing interactions, often leading to frustrations. The subtle interplay of interactions is, in turn, a key ingredient for extraordinary complex phase diagrams exhibited by SCES. Even more interesting are regions of instabilities away from stable phases.The way a new phase emerges close to a phase boundary reveals hidden properties of the studied system. It is extremely important to understand how symmetry breaks in the transition itself and identify the space and time-scales relevant for the changes of order parameter within the transition. Sometimes an intermediate state emerges between two stable phases, bringing new physics to light. This project aims to study some of these new, mostly unexplored states that emerge between well explored stable phases in SCES, or as a consequence of some kind of frustration. In order to obtain a complete picture of new states of matter we will combine several advanced experimental methods: nuclear magnetic and quadrupolar resonance (NMR and NQR) as an atomic-scale, local probe, and nonlinear conductivity as a mesoscopic probe of electronic physics. We will be able to systematically study the many phases and transitions in SCES, provide answers to some currently burning questions, and significantly advance our knowledge about them. In particular, we will study charge order in novel superconductors, and spin liquid and spin nematic states in frustrated quantum spin systems.The project will fully employ the new broadband NMR laboratory in Zagreb, strengthen its visibility and international collaborations, and enable finishing of three PhD theses.]]></summary_en></project><project>
<id>2473</id><title_hr><![CDATA[Sloboda volje, uzročnost i slučaj]]></title_hr><title_en><![CDATA[]]></title_en><user_id>242</user_id><user_firstLast_name>Filip Grgić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-7408</code><acronim><![CDATA[FreeWilL]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filozofija, </scie_field_hr><scie_field_en>Philosophy, </scie_field_en><institution_hr><![CDATA[Institut za filozofiju]]></institution_hr><institution_en><![CDATA[Institute for Philosophy in Zagreb]]></institution_en><team_members_id>17854</team_members_id><team_members_names><![CDATA[ Doktorand: Anna Kocsis ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[free will, causality, luck, determinism, compatibilism, moral responsibility, consciousness]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The overall goal of our research is to contribute to our deeper understanding of what is involved in having and experiencing free will by offering some new insights and arguments in the pertaining areas. The more specific goal of our project is to produce original contributions in some central areas of research into free will, in the following disciplines: metaphysics, philosophy of mind, ethics, history of philosophy, philosophy of physics, as well in philosophical interpretations of relevant results of psychology and neuroscience. The most specific goals of the research are the following. First, we plan to show that deterministic threats to free will are surmountable. Second, we plan to show that indeterministic threats (i.e. those based on randomness and luck) are also surmountable. Third, we will argue that some problems with compatibilistic accounts are more serious than has hitherto been recognized. This is due, first, to the fact that, in our opinion, compatibilism is also susceptible to a specific luck objection, and second, to the fact that it is sometimes based on insufficiently clear notions of causality, determinism and natural laws. Fourth, we will argue that Aristotelian version of compatibilism can bring some fresh light to contemporary discussions, but that it is also susceptible to a specific luck objection.Research activities can be grouped under five main headings: 1. Causality, laws of nature and luck (1.1. Causality, laws of nature and action; 1.2. Indeterminism and luck; 1.3. The varieties of determinism), 2. Brain, mind and agency (2.1. Freedom and consciousness, 2.2. Mental causation and ascriptions of intentionality, 2.3. Some perspectives from neuroscience), 3. Moral responsibility (3.1. Principle of Alternative Possibilities, 3.2. Bioenhancement and responsibility), 4. Aristotelian perspective (4.1. Aristotle’s compatibilism, 4.2. Aristotle on moral responsibility and luck), 5. Free will, determinism and the quantum rescue.]]></summary_en></project><project>
<id>2474</id><title_hr><![CDATA[Napredni tekstilni materijali dobiveni ciljanom modifikacijom površine]]></title_hr><title_en><![CDATA[]]></title_en><user_id>747</user_id><user_firstLast_name>Sandra Bischof</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-5072</code><acronim><![CDATA[ADVANCETEX]]></acronim><duration></duration><status>Prekinut</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Tekstilna tehnologija, </scie_field_hr><scie_field_en>Textile technology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Tekstilno-tehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Textile Technology]]></institution_en><team_members_id>17700</team_members_id><team_members_names><![CDATA[ Doktorand: Iva Matijević ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[advanced materials, textiles, surface modification, fibre reinforced composites, nano-metal particles, LCA, ]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The demand for advanced textile materials has dramatically increased during the last few decades, in particular for engineering, medical and technical applications. A new sight proposed by this project is in the merging of so far separate research teams involved in the development of advanced textile materials, through targeted eco-driven surface modifications. Surface pre-treatments and modification will be carried out on selected sustainable textile materials, using environmentally friendly substances and processes, in order to attain antimicrobial, flame retardant, oil/hydrophobic, wellness or medical properties obtaining high added value textiles. Different environmentally friendly methods of microwave, ultrasound or plasma modification processes will be used to enhance targeted functionalities as well as to increase interfacial adhesion between fibres and polymer matrix in fibre reinforced composites. The other approach of the production of highly active surfaces which will have capability to block UV and microwave radiation, enhance oil and water repellence, antimicrobial, self-cleaning, and flame retardant properties is in the application of micro/nano-particles such as TiO2, ZnO, Cu, Ag and Au. These particles can be applied on the surface of fibers, textiles, clothing or inlayers for footwear. Detailed characterization of each treatment effectiveness, so as their effect on humans and the environment will be investigated. Laundering durability and maintenance properties are equally important as the effectiveness of developed advanced material. Introduction of novel eco-driven surface modification processes in textile production will be complemented by the risk analysis and sustainability issues, focusing onto production and product safety, usage and recyclability of newly developed product without significant environmental burden. Innovative textile products will be directed towards the needs of the textile, chemical, pharmaceutical or medical industries. ]]></summary_en></project><project>
<id>2475</id><title_hr><![CDATA[Istraživanje utjecaja na okoliš primjene nanomaterijala u pročišćavanju voda]]></title_hr><title_en><![CDATA[]]></title_en><user_id>984</user_id><user_firstLast_name>Hrvoje Kušić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-2343</code><acronim><![CDATA[NanoWaP]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Kemijsko inženjerstvo, </scie_field_hr><scie_field_en>Chemical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet kemijskog inženjerstva i tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Chemical Engineering and Technology]]></institution_en><team_members_id>17765</team_members_id><team_members_names><![CDATA[ Doktorand: Marin Kovačić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Water treatment, Advanced oxidation technologies, Photocatalysis, Pharmaceuticals degradation, Nanocomposites, Toxicity]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The water resources globally are facing tremendous pressures due to increased consumption and pollution caused by growing population and industrialization. Thus, the development of advanced treatment technologies is highly required. Technologies using nanomaterials are one of the fast-growing fields creating variety of new commercial nanoparticles. One of the innovative applications of nanomaterials with a great potential involve their usage as water treatment tools. The photocatalytic treatment using nano-TiO2 as a destructive and “zero” waste method for water purification provides a synergy of advanced oxidation technologies and nanomaterials application with a great potential to be commercialized. However, some features of TiO2 photocatalysis, its mechanical and chemical stability, have to be improved to minimize the potential negative implications.The main goal of NanoWaP project is to develop the sustainable photo-AOT with nanocomposite photocatalysts for the purification of water containing pharmaceuticals. In order to overcome the limitations of nano-TiO2 technologies: agglomeration tendency, post-separation, low activation potential under the sunlight, novel nano-TiO2-based composites with iron-exchanged zeolites and SnS2 will be investigated for degradation of pharmaceuticals in water. The efficiency will be evaluated using an innovative integral approach including: (i) pharmaceuticals removal expressed in a terms of common ecological parameters, (ii) energy consumption per decreased concentration of chosen ecological parameter for one order of magnitude, and (iii) the assessment of adverse environmental effects. Besides, the photocatalysts characterization prior and after the treatment would provide an additional insight in its stability which will be also examined through consecutive runs.]]></summary_en></project><project>
<id>2476</id><title_hr><![CDATA[Očuvanje mikrobne raznolikosti povezane s proizvodnjom tradicionalnih hrvatskih kobasica od mesa  divljači: biotehnološka i sigurnosna karakterizacija]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4884</user_id><user_firstLast_name>Mirna Mrkonjić Fuka</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-5664</code><acronim><![CDATA[miCROgame]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Agronomski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Agriculture]]></institution_en><team_members_id>17813</team_members_id><team_members_names><![CDATA[ Doktorand: Ana Žgomba Maksimović ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[traditional game meat sausages, lactic acid bacteria, foodborn pathogens, antibiotic resistance, starter cultures]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Despite the fact that nowadays the utilization of starter cultures is a prerequisite for the meat industry, as product reproducibility, reduction of fermentation times and enhancement of organoleptic characteristics is achieved, small scale producers in Croatia still produce spontaneously fermented game meat sausages as they still surpass in sensorial properties. Such artisan products are increasingly appreciated because of their authenticity although of great consideration due to their variable microbiological and organoleptic quality. Overall monitoring of wildlife reservoir is needed in assessment its potential as sources for zoonosis agents exposures of humans as well as sources of bacterial strains relevant for enhancement and standardization of game meat sausages production. There are large variations in prevalence of microbial populations of game meat even within a single country and the published data for Croatia is limited and poorly documented which does not allow any related analysis. Especially the data on risk -based monitoring of zoonosis and antibiotic resistance genes transmission via game meat food chain in Croatia is missing and there is not authentic collection of indigenous bacterial strains that could act as a pool of novel genes and metabolic pathways relevant for high quality food production. MiCROgame focuses on the in situ diversity analysis as well as detailed characterization of lactic acid bacteria (LAB) isolated from traditional Croatian game meat sausages. Application of this autochthonous microbiota into the sausages production can influence the end-product quality and can accelerate maturation such helping producers to be more competitive on national or EU market. Special focus will be set towards identification and characterization of potential spoilage and pathogenic microflora and antibiotic resistance traits in order to estimate safety of locally produced game meat food and to identify sources of contamination. ]]></summary_en></project><project>
<id>2479</id><title_hr><![CDATA[Raznolikost i interakcije kestena, patogene gljive koja izaziva rak kestena i virusa koji inficira gljivu: učinak na oporavak kestena]]></title_hr><title_en><![CDATA[]]></title_en><user_id>761</user_id><user_firstLast_name>Mirna  Ćurković Perica</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-8059</code><acronim><![CDATA[Chestnut]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>17770</team_members_id><team_members_names><![CDATA[ Doktorand: Lucija Nuskern ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[biological control, chestnut disease, epigenetics, hypovirulence, molecular ecology]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[European sweet chestnut is an important multipurpose tree species. For decades, chestnut blight, a disease caused by one of the world´s most aggressive invasive pathogens Cryphonectria parasitica has been causing high mortality in chestnut forest populations and orchards. However, the fungus can be controlled by the naturally-occurring virus Cryphonectria hypovirus 1 (CHV1) which causes a reduction in fungal virulence and sporulation (a phenomenon called hypovirulence), which in turn enables infected trees to recover. Hypovirulence is the most efficient way to successfully control chestnut blight in Europe, but unfortunately the spread of CHV-1 is limited by the fungal diversity and its sexual reproduction. This project aims at revealing individual and joint aspects of the dynamic three-lateral interaction between chestnut, its fungal pathogen and the pathogen-biocontrol agent-virus. The proposed study will: (1) reveal the diversity of natural chestnut populations in south-eastern Europe, (2) connect the sequences and 3-D structures of CHV1 subtype I proteins with the level of fungal hypovirulence, (3) reveal the role of epigenetic changes of fungal genome in respect to hypovirus infection and geographical spread of the fungus (4) assess the efficiency of naturally-occurring virus isolates to induce chestnut recovery in natural conditions. The results will also contribute to the combat efforts against chestnut blight in the field conditions, by enabling production of therapeutic paste for induction of recovery in a valuable chestnut cultivar.]]></summary_en></project><project>
<id>2480</id><title_hr><![CDATA[Karakterizacija niskotemperaturne molekulske dinamike sustava s neuređenom rešetkom metodom ESR]]></title_hr><title_en><![CDATA[]]></title_en><user_id>510</user_id><user_firstLast_name>Marina Ilakovac Kveder</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-9812</code><acronim><![CDATA[DESiRe]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>17790</team_members_id><team_members_names><![CDATA[ Doktorand: Jurica Jurec ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[ESR, disorder, boson peak, spin relaxation, spin frustration]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Systems exhibiting geometrical frustration challenge contemporary condensed-matter physics due to the fact that they exhibit strange dynamical properties such as boson peak excitations, which strongly deviate from the standard Debye model. Therefore, the quest for a self-consistent theory applicable for description of systems with lattice disorder is a fundamental issue. Despite the efforts put into investigation of vibrational excitations in disordered systems at low temperatures, the consensus about their physical origin is still lacking. This project aims to address the subject by fully exploiting the advantage of embedded paramagnetic centres through focusing on their relaxation behaviour, which bears the information about the local frustration of the environment. The energy exchange within the spin system and between the spin system and the lattice will be detected by electron spin resonance spectroscopy (ESR) as a function of disorder in the vicinity of the paramagnetic centre. This we can control by preparing the host matrix in the glassy, supercooled or crystalline state. We propose to investigate the specific molecular dynamics due to the presence of disorder in the system while switching the very same compound doped with paramagnetic centres from disordered to more ordered state, such as from glassy to crystalline state. Additionally, the microscopic picture of local disordered sites will be examined in other systems doped with paramagnetic centres such as various polymer matrices or hydrogen-bonded crystals. The origin of local disorder will be correlated with the influence of different numbers of hydrogen bonds in the vicinity of paramagnetic site as well as with the degree of local spin frustration. We expect that this comparative study will enlighten the peculiarities of vibrational density of states of amorphous materials and contribute towards development of the unique model of low-temperature molecular dynamics of disordered systems in general.]]></summary_en></project><project>
<id>2481</id><title_hr><![CDATA[Rekombinacija, popravak DNA i očuvanje integriteta genoma: novi putevi]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5202</user_id><user_firstLast_name>Davor Zahradka</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-3252</code><acronim><![CDATA[RECNEWPATH]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>17821</team_members_id><team_members_names><![CDATA[ Doktorand: Ana Hlevnjak ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[hommologous recombination, DNA repair, genome stability, Escherichia coli, Deinococcus radiodurans, RecA protein, gross chromosomal rearrangements]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Homologous recombination is an essential biological process that is involved in DNA repair and in the maintenance of genome integrity. The RecA protein is a key component of recombinational systems in bacteria. Its homologs are also present in higher organisms including humans. RecA functions in the form of nucleoprotein filaments that are assembled on single-stranded DNA, and which catalyze pairing and strand exchange between two homologous DNA duplexes. In Escherichia coli, the RecBCD and RecFOR protein complexes mediate RecA filament assembly, and consequently, play an important role in recombination. We have recently discovered that some E. coli mutants recombine quite efficiently in the absence of both RecBCD and RecFOR complexes. This recombination is RecA-dependent suggesting the existence of an alternative RecA loading activity. The aim of the project is to genetically characterize this RecBCD- RecFOR-independent (RecBFI) recombination pathway, and gain insight into this novel mechanism of RecA filament assembly. Although RecA is crucial for efficient recombination in bacteria, the recA mutants of radiation-resistant bacterium Deinococcus radiodurans display a significant residual ability to repair double-strand DNA breaks. Recent results from our group have shown that this RecA-independent repair is quite inaccurate leading to gross chromosome rearrangements. Our project is to identify the key genes/proteins involved in this RecA-independent repair, and to characterize, at the sequence level, gross genome rearrangements in D. radiodurans. Given that recombination is a fundamental process largely conserved during evolution, our research on bacteria may reveal molecular mechanisms that are applicable to eukaryotic recombination systems. Thus, the results of our project could be instructive for research on cancer and other human hereditary diseases related to defects in DNA recombination functions. ]]></summary_en></project><project>
<id>2482</id><title_hr><![CDATA[Mulitidisciplinarni pristup otkriću lijekova s ciljanim djelovanjem na matične stanice tumora – uloga transporta kalija ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>613</user_id><user_firstLast_name>Marijeta Kralj</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-3177</code><acronim><![CDATA[MultiCaST]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>17804</team_members_id><team_members_names><![CDATA[ Doktorand: Iva Guberović ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[cancer stem cells, potassium transport, salinomycin, crown ethers, ion channels, ABC transporters, predictive QSAR modeling, drug discovery, therapy]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Targeting cancer stem cells (CSC), rather than cancer cells in general, is a novel and highly promising strategy for cancer treatment. The defining characteristics of CSC are self-renewal, propagation into heterogeneous lineages of cancer cells, and increased resistance to chemotherapy, thus, attacking the CSC should abolish a tumor&#39;s ability to recur or metastasize. Recently, a natural potassium ionophore salinomycin was identified as one of a few available CSC-selective substances, but the precise mechanism of its selectivity remains elusive. Based on hypothesis that the potassium transport is an important process of CSC biology, the objective of the proposed research is to understand fundamental processes of CSC-resistance to therapy and to discover novel compounds with ion homeostasis-modulating properties to selectively target CSC. Project methodology orchestrates research in three principle areas and their close interactions, covering synthesis and characterization of molecules (chemistry), assessment of their activity in biological models (biology, medicine) and computer-aided drug design (computational sciences). We’ll focus on salinomycin and a series of proprietary crown ether compounds, which will be optimized and developed. Their efficacy/selectivity and influence on drug transporters P-gp- and/or ABCG2-mediated efflux of chemoterapeutics will be assessed, as well as the toxicity and in vivo activity of the most promising compound. Deploying cutting-edge techniques in cell and molecular biology, bioimaging, molecular electrophysiology and transgenic cell lines (e.g. a unique CSC model - HMLEshEcad cells) we will strive to recognize novel biomarkers for identification and enrichment of CSC, related to abnormal potassium transport regulation that promote acquisition of CSC phenotype and/or influence their proliferation, death and migratory potential. The ultimate aim is to translate this knowledge into innovative mechanism-based therapeutic approaches. ]]></summary_en></project><project>
<id>2483</id><title_hr><![CDATA[Dijagnostika Interakcije lasera i hladne plazme]]></title_hr><title_en><![CDATA[]]></title_en><user_id>140</user_id><user_firstLast_name>Slobodan Milošević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-3950</code><acronim><![CDATA[LaCPID]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut za fiziku]]></institution_hr><institution_en><![CDATA[Institute of Physics in Zagreb]]></institution_en><team_members_id>17797</team_members_id><team_members_names><![CDATA[ Doktorand: Dean Popović ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[low temperature plasmas, laser produced plasmas, cold plasmas, atmospherics plasmas, laser spectroscopy]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Cold and low-density plasmas are currently in focus of basic research worldwide due to many open questions regarding their complex nature and simultaneously due to their high potential for applications in various fields of research and technology. Plasmas can be produced by bombarding matter either with energetic electrons or with energetic photons. The first kind is related to use of various discharges and the second to use of powerful lasers. Our interest is in plasmas produced in vacuum, under low-pressure gas environment, at atmospheric air or on/within liquids. Discharges which we use range from electrodeless, single electrode to various designs of two electrode systems. Lasers we use are cw or pulsed nanosecond.  In our research special care will be devoted to tailoring the electron energy distribution functions as a key factor influencing plasma content and features. This is usually done by changing macroscopic plasma parameters - gas pressure, electrical fields and geometry of discharges. In this project we shall combine laser produced plasmas with discharge plasmas to achieve that goal. To understand the complex nature of plasma or processes of plasma interaction with other matter phases (gases, liquids and solids) basic approach is to perform plasma diagnostics by various types of optical and laser spectroscopies. To interpret findings we study basic atomic collision processes in plasmas and structure and spectra of various complexes formed within plasma (dimers, radicals etc). Modeling of various processes within cold plasmas and laser produced plasmas is performed in addition. In various applications in which plasma treatment of matter is used there is a need for in situ monitoring of processes both in plasma and at interfaces and therefore both spatial and temporal spectral resolution of applied detection techniques are important. We use classical emission and absorption laser spectroscopies and modern techniques such as a cavity ring-down spectroscopy.]]></summary_en></project><project>
<id>2484</id><title_hr><![CDATA[Klasifikacija i objašnjenja antisocijalnog poremećaja osobnosti i moralna i kaznena odgovornost u kontekstu Hrvatskog zakona o mentalnom zdravlju i skrbi]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4121</user_id><user_firstLast_name>Luca Malatesti</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-9522</code><acronim><![CDATA[CEASCRO]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filozofija, </scie_field_hr><scie_field_en>Philosophy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Filozofski fakultet u Rijeci]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>4172</team_members_id><team_members_names><![CDATA[ Doktorand: Marko Jurjako ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[antisocial personality disorders, psychiatric classification,  psychiatric explanation, moral responsibility,  Croatian mental health law and care]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[This interdisciplinary project investigates the problem of the social response in Croatia to a class of offenders classified as having antisocial personality disorders. The core methodology consists in  conducting philosophical investigations that are aimed at offering practical recommendations and that are constrained by knowledge of the practical setting of Croatian mental health law and care.  Two central philosophical issues appear to be relevant to the philosophical investigation and, thus, addressing them  is the aim of the project. First, a significant part of the contemporary debate on the social response to antisocial personality disorder centers on this notion. Some have argued that this notion involves normative preconceptions  against the liberties of certain individuals. Others have questioned the accuracy and scientific robustness of the diagnosis of antisocial personality disorders and its precision of related risk predictions.  Second, the justification for choosing the appropriate treatment for people with antisocial personality disorder must also be a moral one. In particular, a relevant type of moral justification has to be grounded in principles that correlate psychological descriptions and explanations of a person’s behavior with his or her degree of responsibility.  Similarly, compulsory treatment appears to be conditional upon a person’s diminished responsibility or capacity to act accordingly to a treatment decision, together with the existence of a risk to themselves or to others.The philosophical investigation of the project will be integrated with the contributions of  a leading forensic psychiatrist in Croatia, a sociological qualitative analysis of the practices and challenges that are encountered by institutional representatives in the forensic department of the Rab psychiatric hospital and an historical investigation of the institutional response to antisocial personality disorder in the region in the period 1918-1980.]]></summary_en></project><project>
<id>2486</id><title_hr><![CDATA[Nestali jezerski krajobrazi istočnog dijela Jadranskog mora]]></title_hr><title_en><![CDATA[]]></title_en><user_id>162</user_id><user_firstLast_name>Slobodan Miko</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-7454</code><acronim><![CDATA[ LoLADRIA]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Geologija, </scie_field_hr><scie_field_en>Geology, </scie_field_en><institution_hr><![CDATA[Hrvatski geološki institut]]></institution_hr><institution_en><![CDATA[Croatian Geological Survey]]></institution_en><team_members_id>17774</team_members_id><team_members_names><![CDATA[ Doktorand: Dea Brunović ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Paleolimnology, Paleoclimate, Last Glacial Maximum, Holocene, Pleistocene, Mesolithic, Sea Level Rise, Proxies, Human Migration, Adriatic Shelf, Karst]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The LoLADRIA project represents a multidisciplinary, effort to recover, for the first time, long paleoenvironmental, and paleoclimate records from existing coastal karst lakes and submerged karstic lakes of the eastern Adriatic shelf in Croatia. The project will attempt to reconstruct the specific karst lake landscapes and their surroundings in view of environmental and climate change and human migration from the Last Glacial Maximum (LGM) through the Holocene. LoLADRIA will provide long, high resolution, paleohydrological reconstructions from a region extremely sensitive to changes in effective moisture and atmospheric dynamics. The multiproxy-based reconstructed curves will provide new data to identify and date the main climate events, and to characterize the climate variability at century and millennium scale since the LGM. Pollen and ostracods offer the possibility to develop transfer functions in order to reconstruct quantitative changes in regional climate and hydrological conditions of the lakes. LoLADRIA will offer an environmental context which enabled the human entrance to Europe along the eastern Adriatic shelf since this pathway is still widely unknown and the detailed framework of climatic and environmental conditions still requires extensive research. In combination with landscape reconstruction based on high resolution geophysical methods will allow the insight to the preserved changes in the landscapes at selected sites along the Eastern Adriatic and their habitability related to the Mesolithic cultures that were present there. Submarine  prehistoric  sites  in  the  Mediterranean  show  that  the  continental  shelf was  occupied  by  humans  to  a  depth  of  at  least  -40m, and the lost (submarine) lakes and surrounding submerged landscapes of the eastern Adriatic have a potential for site discovery.]]></summary_en></project><project>
<id>2487</id><title_hr><![CDATA[SINTEZA I CITOSTATSKA ISPITIVANJA  BIBLIOTEKE NOVIH DUŠIKOVIH HETEROCIKLA]]></title_hr><title_en><![CDATA[]]></title_en><user_id>76</user_id><user_firstLast_name>Silvana Raić-Malić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-4842</code><acronim><![CDATA[SCIENcENTRY]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet kemijskog inženjerstva i tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Chemical Engineering and Technology]]></institution_en><team_members_id>17839</team_members_id><team_members_names><![CDATA[ Doktorand: Andrea Bistrović ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[1,2,3-triazole-heterocycles hybrids, benzimidazoles, benzothiazoles, synthesis, cytostatic activity, in silico and docking analysis, DNA binding]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Cancer is one of the most serious health problems of a worldwide dimension. One in three of the population develops cancer at some time in their lives and one in four dies from this disease. The main problems in antitumor chemotherapy are drug resistance and side effects on normal tissues. In the recent years a tremendous growth was witnessed in synthesis and development of vast number and types of new heterocyclic antitumor agents, with an emphasis on creation of new drugs with better selectivity or activity. The latter are indeed major requirements in development of novel anticancer drugs. The proposed scientific project is highly interdisciplinary and objective-oriented with the principal aim to develop the novel lead compounds with pronounced and selective anticancer activity that would be used for further phases of drug development.To achieve the principal aim following specific tasks are foreseen. The goal of the first one is to synthesize small-compound library (Classes A–H) comprising new conjugates of pseudopurines, coumarines and quinolines with 1,2,3-triazole scaffold, N-acyclic 5-unsaturated pyrimidine derivatives, amino-, amido- and amidino substituted benzimidazole, benzothiazole and benzo[b]thieno-2-carboxamide derivatives. Molecule library will be synthesized using modern synthetic approaches such as click chemistry, palladium mediated cross-coupling, eco-friendly microwave assisted and photochemical reactions as well as classical organic synthetic methods. The aim of the second task is to predict plausible biological targets and pharmacological activities using cheminformatics/in silico analysis. The third task is to perform cytostatic evaluations based on which hit molecules with desired biological effect will be selected for structure optimization that will be subsequently carried out. Finally, the molecular mechanism studies are anticipated for the most effective compounds from synthesized N-heterocycles library.]]></summary_en></project><project>
<id>2488</id><title_hr><![CDATA[Sensitive measurement, detection, and identification of engineered nano particles in complex matrices – SMARTNANO (FP7 - NMP.2011.1.3-1 - Contract n°280779)]]></title_hr><title_en><![CDATA[]]></title_en><user_id>504</user_id><user_firstLast_name>Željko Jakšić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-6175</code><acronim><![CDATA[]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>17752</team_members_id><team_members_names><![CDATA[ Doktorand: Maja Levak ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>2489</id><title_hr><![CDATA[Periodički npregnuti grfen; strukturna i elektroska svojstva]]></title_hr><title_en><![CDATA[]]></title_en><user_id>105</user_id><user_firstLast_name>Petar Pervan</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-6205</code><acronim><![CDATA[PerStaGra]]></acronim><duration></duration><status>Prekinut</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut za fiziku]]></institution_hr><institution_en><![CDATA[Institute of Physics in Zagreb]]></institution_en><team_members_id>17783</team_members_id><team_members_names><![CDATA[ Doktorand: Ivan Jedovnicki ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[graphene, strain, vicinal surface, fermi velocity, spin-orbit coupling, STM, ARPES]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[A strained graphene offers a valuable avenue for the manipulation in altering its electronic structure. Graphene can withstand rather large elastic deformation and it appears that within the elastic response there is a range of different modifications in graphene’s electronic structure. This is a basis of what is called “strain engineering”. Recent theoretical calculations suggest that uniaxial strain or shear deformations can induce opening of the electron band gap, anisotropic modification of the Fermi velocity, spin-orbit interaction  and consequently alter the transport properties. However, there is still no consensus on the mechanical conditions required to obtain a particular electronic modification. In this project we propose a systematic study of structural and electronic properties of periodically rippled graphene. We have already demonstrated that graphene conforms to the stepped (vicinal) iridium surface – Ir(332) creating periodic structure at nanometer scale. It is aim of this project to experimentally explore the dependence of the electronic structure of graphene with respect to periodicity of the graphene corrugation, orientation of the graphene with respect to the shear deformation (zig-zag with respect to armchair direction). By intercalation of different elements we will alter the graphene substrate interaction with the aim to control the structure of the underlying surface and consequently valence band structure of graphene. We shall investigate structural properties of graphene on Ir(332) by Scanning Tunneling Microscope (STM) and Atomic Force Microscope (AFM). The focus in the investigation of electronic properties will be on the ARPES study of anisotropic distortion of the Dirac cone, relation with the direction of the graphene modulation, spin-orbit interaction and on the possibility to induce electron band gap. ]]></summary_en></project><project>
<id>2491</id><title_hr><![CDATA[Metode slabih convergencija i primjene]]></title_hr><title_en><![CDATA[]]></title_en><user_id>58</user_id><user_firstLast_name>Nenad Antonić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-1949</code><acronim><![CDATA[WeConMApp]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>86</team_members_id><team_members_names><![CDATA[ Doktorand: Marin Mišur ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[weak convergences, partial differential equation, homogenisation, optimal design, H-measures, semiclassical measures, transport problems]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Weak convergences are the foundation of most successful methods in the investigation of partial differential equations today. The approach known as Tartar&#39;s programme proved particularly convenient for partial differential equations modelling physical laws; the basic assumption being that weak convergences of sequences of solutions model the transition from microscale to macroscale. Of importance are also mathematical objects being, in a generalised sense, accumulation points of weakly convergent sequences, such as defect measures or H-measures. The research will be directed towards improving the existing weak convergence methods, designing new mathematical objects for that purpose, as well as developing new methods, with particular attention paid to their applications to practical problems.Problems known as homogenisation are tied to properties of mixtures of materials, with important applications in optimal design. Problems related to evolutionary equations and their admissibility conditions mainly concern transport problems in free and porous media, where it is sometimes natural to include continuous time random walk variables in the model. Such problems sometimes also lead to fractional derivative equations. Some problems are related to hyperbolic conservation laws and the propagation and interaction of singularities. High-frequency waves corresponding to solutions of hyperbolic systems are governed by ODEs, allowing for final interpretation as particles. Particularly interesting are situations where the equation changes its type (like transonic fluid flow), motivating our interest in Friedrichs systems. Further results for semilinear systems could open a new approach to the Maxwell-Dirac system, with potential applications in quantum field theory. Practical computation of coefficients in specific applications is also important; as the unknown functions have the domain in multidimensional space, quite often more efficient numerical methods have to be developed.]]></summary_en></project><project>
<id>2492</id><title_hr><![CDATA[LIFE13 ENV/HR/000580 „Niskopesticidna integrirana zaštita u održivoj i sigurnoj proizvodnji voća&#39;&#39;]]></title_hr><title_en><![CDATA[]]></title_en><user_id>253</user_id><user_firstLast_name>Tomislav Jemrić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-5032</code><acronim><![CDATA[]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Biotehnologija, </scie_field_hr><scie_field_en>Biotechnology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Agronomski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Agriculture]]></institution_en><team_members_id>17827</team_members_id><team_members_names><![CDATA[ Doktorand: Marko Vuković ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>2493</id><title_hr><![CDATA[Fleksibilna energetska čvorišta u nisko ugljičnim naprednim elektroenergetskim mrežama]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6497</user_id><user_firstLast_name>Igor Kuzle</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-5507</code><acronim><![CDATA[FENISG]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>19028</team_members_id><team_members_names><![CDATA[ Doktorand: Kristina Jurković ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[energy/power nodes, smart grids, reneawable energy sources, distributed generation, energy storage, plug in electrical vehicles]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The share of renewable energy sources (RES) in electric power systems (EPS) has increased during the recent years and this trend is expected to continue. The stochastic nature of electricity production from RES imposes new challenges for the EPS operation and control. A large share of undispatchable RES can lead to significant disturbances of EPS components. These disturbances need to be balanced out and the security of the system has to be preserved. If the resources for providing balancing energy and flexibility are limited, secure operation of the EPS will become highly expensive. Conventional generation units provide the necessary flexibility to maintain a continuous balance between supply and demand. The question is: are these conventional resources the most feasible way of providing system flexibility in the future low carbon systems? During the recent years, plug-in hybrid electric vehicles (PHEV) have become an attractive way of transportation. While passive approach to their integration might cause problems to the system, active utilization of their flexibility might enable higher penetration of RES. A similar reasoning can be applied to the distributed generation, especially technologies with the potential of multi energy vector interaction (efficient electric heating, combined heat and power, battery storage etc.).Current grids need to be capable of dealing with mentioned requirements. The concept of Smart Grid (SG) is based on using of novel information and communication technology (ICT) and includes application of a spectrum of innovative and flexible technologies.The purpose of this project is to establish a methodological and comprehensive framework providing the costs and benefits evaluation of SG projects and technologies. Given the sizeable investments needed, there is a need for a fair, consistent and methodological approach for estimation of the best investment option, taking into account economic and environmental aspects of a specific project.]]></summary_en></project><project>
<id>2494</id><title_hr><![CDATA[Zaštita privatnosti deidentifikacijom u nadzornim sustavima ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4290</user_id><user_firstLast_name>Slobodan Ribarić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-2427</code><acronim><![CDATA[DePPSS]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>17749</team_members_id><team_members_names><![CDATA[ Doktorand: Martin Soldić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[privacy protection, biometric identification, de-identification, surveillance systems, video ]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Owing to advances of video surveillance systems it is possible, besides detection of people&#39;s behavioural anomalies, by using of reliable recognition software to perform identification and simultaneously trace people in the real time. Whilst it is recognized that there are justified reasons for acquisition and sharing videos in manners such as security, bio-terrorism surveillance applications, low enforcement and forensics, there is also a strong need for protecting the privacy of the guiltless individuals who are inevitably captured in the recordings. Video surveillance is privacy intrusive because it allows the observation of certain information that is considered privacy intrusive. Face has central role in the process of human recognition and identification in videos, thus the special attention has to be devoted to the face de-identification methods for privacy protection. De-identification addresses, in context of our project, the automated methods of concealing or/and removing face identifiers of individuals captured in videos. The importance of privacy protection is mirrored in documents such as UN Universal Declaration of Human Rights, and EU’s Data Protection Directive (95/46/EC) as well as commissioned review of the Data Protection Directive (95/46/EC) by the EU Information Commissioner’s Office from July 2008. The general public has become increasingly aware of the potential danger for their personal data to be abused.Beside scientific objectives and goals (robust face localization, novel methods for face de-identification in videos, preserving data utility and naturalness in de-identification videos, privacy protection), the main objectives of the proposed project are human resources (early stage researchers and PhD students) development by transfer of knowledge in the fields of advanced technologies to carry out problem-oriented research, and increasing a competitiveness level of the research team for Horizon 2020 project applications. ]]></summary_en></project><project>
<id>2495</id><title_hr><![CDATA[Towards an alliance of European research fleets (EUROFLEETs-II) ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>195</user_id><user_firstLast_name>Ivica Vilibić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-5127</code><acronim><![CDATA[]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Geofizika, </scie_field_hr><scie_field_en>Geophysics, </scie_field_en><institution_hr><![CDATA[Institut za oceanografiju i ribarstvo]]></institution_hr><institution_en><![CDATA[Institute of Oceanography and Fisheries]]></institution_en><team_members_id>17732</team_members_id><team_members_names><![CDATA[ Doktorand: Natalija Dunić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>2499</id><title_hr><![CDATA[Unaprijeđeno istraživanje općekorisnih funkcija šuma]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3207</user_id><user_firstLast_name>Damir Medak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-4224</code><acronim><![CDATA[AFORENSA]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Geodezija, </scie_field_hr><scie_field_en>Geodesy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Geodetski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Geodesy]]></institution_en><team_members_id>17863</team_members_id><team_members_names><![CDATA[ Doktorand: Luka Rumora ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Forest environmental services, Remote sensing, Ecohydrology, Biodiversity, GIS, Climate change ]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The main objective of AFORENSA is to generate relevant knowledge how the forest ecosystems in Croatia responds to observed extreme climatic variations, and what are possible future expectations in respect to the progression of climate change and disturbances of natural hydrologic cycle with intensification of drought frequency and severity. This objective is aimed to be resolved by implementing of the novel forest ecosystem assessment approach, applicable for the country scale, which incorporates: a) traditional in situ ecosystem survey (soil and vegetation), b) analysis of the functional state of the ecosystems by remote sensing, c) downscaling of the regional climatic models and d) coupling of scenario outputs with ecohydrological models on a site specific environmental settings. The core system on which AFORENSA activities will be build up, presents “Dynamical Geoinformation system of forest ecosystems in Croatia” (DYN-CROFOR), a technological project financed by the Ministry of Science and Education from 2003 to 2007. Aforensa is aiming at the inventory, and integration of terrestrial forest ecosystem research on the Web-Gis (DYN-CROFOR) platform incorporating automatized procedures for retrieving remote sensing data (such as MODIS and MERIS vegetation indices)  and with the  addition of incorporating Data mining procedures and the full power of R, a language and environment for statistical computing and graphics. Project workflow consists of four, interrelated, work packages: a) INVENTORY, b) AUTOMATIZATION, c) MINING, d) UPGRADING. AFORENSA will contribute with speeding-up of future exploratory forest ecosystem research, and with its capability of near real time data processing will present a basis for the development of “Forest watch”; an observatory for early determination of potentially harmful effects of Climate Change on forest ecosystem services such as biodiversity and water.]]></summary_en></project><project>
<id>2501</id><title_hr><![CDATA[Računalna rješenja u bioznanostima: Značaj savitljivosti molekula]]></title_hr><title_en><![CDATA[]]></title_en><user_id>326</user_id><user_firstLast_name>David Smith</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-6776</code><acronim><![CDATA[CompSoLS-MolFlex]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>18936</team_members_id><team_members_names><![CDATA[ Doktorand: Marko Hanževački ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Molecular Flexibility, Computational Chemistry, Peptides, Proteins, Enzyme Catalysis]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Molecular flexibility controls a number of key processes ranging from protein folding to the design of advanced materials. However, the detailed understanding of its impact on a given process is poorly understood. Direct investigation of this phenomenon by experimental means, is a challenging endeavour, as the microscopic details are frequently hidden from macroscopic observations. Computational simulations, on the other hand, provide detailed information regarding molecular dynamics and flexibility. The theoretical approach is thus crucial in both understanding the experimental results and in expanding the underlying conceptual framework.The present project proposes to utilize state-of-the-art computational techniques to address the importance of molecular flexibility across a range of carefully selected examples from the life sciences. The examples, which can be classified under the headings: (i) peptides and spectroscopy, (ii) protein flexibility, and (iii) enzyme related transformations, have been chosen to span multiple time and length scales and thus to highlight the diverse and wide-reaching nature of molecular flexibility. The selected examples exhibit a significant degree complementarity and synergy with one another and are all associated with their own applicative importance in different areas of (bio)chemistry.In addition to the scientific research proposed, the project aims to consolidate a highly successful and competitive platform in computational life sciences that has been established at the RBI. This platform was already recognized through the granting of an EU-FP6 project (2007-2010). The current project team is thus well equipped for the proposed work and exhibits a good balance between senior researchers, with excellent track records, and junior scientists with outstanding potential. The support of the project team by HrZZ is crucial for maintaining their competitiveness in the international scientific environment of computational life sciences.]]></summary_en></project><project>
<id>2502</id><title_hr><![CDATA[Jezična obrada u odraslih govornika]]></title_hr><title_en><![CDATA[]]></title_en><user_id>400</user_id><user_firstLast_name>Jelena Kuvač Kraljević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-3854</code><acronim><![CDATA[ALP]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Logopedija, </scie_field_hr><scie_field_en>Logopedics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Edukacijsko-rehabilitacijski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Education and Rehabilitation Sciences]]></institution_en><team_members_id>17791</team_members_id><team_members_names><![CDATA[ Doktorand: Marina Olujić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[language processing, adult and elderly population, language disorders, executive functions, linguistic aphasiology]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Adult Language Processing project is intended to address psycholinguistic and neurolinguistic aspects of the aging population in Croatia. As an installation research project it will help set up an interdisciplinary and multidisciplinary research group that would tackle all aspects of the language processing in adults and in the aging population. Clinical groups (patients with aphasias, dementias and dyslexia) will be included into the project; language breakdown in these clinical groups helps in the study of language processing in healthy adults and vice versa. It is generally assumed that the subtle changes in language processing in the aging population arise from the cognitive decay related to executive functions, not language per se. The decrease in the processing speed influences language processes that require fast execution or simultaneity. This results in a typical pattern of changes, different from the ones in clinical populations. Therefore, executive functions in these groups will be studied in order to build a comprehensive model of adult language processing. Theories of language processing (namely, Role and Reference Grammar - RRG) will be considered to define specific traces of language processing that assume fast execution or simultaneity and therefore should be the most vulnerable in aging population. These traces will be defined and described which will put Croatian into a cross-linguistic perspective in contemporary studies of linguistic aphasiology and provide coherent picture of age related changes in adult language system.  ]]></summary_en></project><project>
<id>2503</id><title_hr><![CDATA[Optimiranje i modeliranje termalnih procesa materijala]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1419</user_id><user_firstLast_name>Dario Iljkić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-4469</code><acronim><![CDATA[OMOTPOM]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, </scie_field_hr><scie_field_en>Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Tehnički fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Engineering]]></institution_en><team_members_id>25439</team_members_id><team_members_names><![CDATA[ Doktorand: Andrej Borić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[materials processing, modelling, electroless plating, electroactive composites, optimisation, modelling]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Phenomena of physical processes during the thermal processes will be investigated. Methods for modeling and computer simulations of thermal processes of materials will be developed. Thermal processes, such as, heat treating processes of steel, hot pressing of powder metals and casting of alloys of light metals will be investigate. The study of heat treatment of steel will be focused on quench hardening and tempering, and control cooling during the hot working and steel casting. Thermal stability of electro-active composites will be analyzed. Optimization of electro-less Ni-P coating of stainless steel and thermo-diffusive heat treatment of layers will be studied. Methods of optimization of application of tools and dies in thermal processing of materials will be studied. Models and computer programs for simulation of behavior steel dies during casting of light metal alloys and hot pressing of metal powders will be developed.During the thermal processes primary will be studied physical processes and material properties such as: heat transfer, microstructure transformations, mechanical properties and distortions and residual stresses. Numerical model of physical phenomena will be preferable based on finite volume method (FVM). To solve these tasks, joined thermo-mechanic-metallurgical approach will be required. The computer program for 3-D simulation of heat transfer, microstructure transformations, mechanical properties, distortions and residual stresses during the thermal processes will be developed.]]></summary_en></project><project>
<id>2504</id><title_hr><![CDATA[Modeliranje toka podzemnih voda u krškim vodonosnicima]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6687</user_id><user_firstLast_name>Hrvoje Gotovac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-4310</code><acronim><![CDATA[Karst modelling]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Građevinarstvo, </scie_field_hr><scie_field_en>Civil engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu Fakultet građevinarstva, arhitekture i geodezije]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Civil Engineering, Architecture and Geodesy]]></institution_en><team_members_id>17887</team_members_id><team_members_names><![CDATA[ Doktorand: Luka Malenica ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[karst aquifers, groundwater flow modeling, multiresolution and multiscale approach, karst heterogeneity, distributive karst models]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Karst aquifers are very important groundwater resources around the world as well as in coastal part of Croatia. They consist of extremely complex structure defining by triple phases: slow porous medium, mostly laminar fractures and usually fast turbulent conduits/karst channels. Usually, karst aquifers have been analyzed by lumped hydrological models which ignore high heterogeneity of karst and consider only input (precipitation) and output (spring discharge) due to lack of extensive other input data and knowledge regarding the karst system. Last two decades full hydraulic (distributive) models have been developed exclusively by conventional finite elements considering karst heterogeneity structure that improves our understanding of complex processes in karst. Therefore, in this project we will develop novel “unique” flow model based on multi-resolution approach originally designed by Gotovac et al. (2007-2013) for 1-D and 2-D groundwater flow and transport simulations. Proposed approach is based on Fup basis functions with compact support and meshless collocation procedure enabling multi-scale representation of heterogeneity and other flow variables, closely related to the karst flow physical interpretation. Moreover, extending existing procedure to 3-D and constructing separate multi-scale solution for all three karst phases, proposed approach will enable the following impacts in comparison to conventional methods: desired spatial and temporal accuracy and high computational efficiency, modular model structure, incorporation of different heterogeneity scales related to existing measurements, enabling of transport and tracer test analysis and better understanding of karst aquifers due to solving of different engineering problems such as water usage and protection or contaminant pollution. Flow model will be verified by laboratory experiments and numerical synthetic benchmarks as well as real examples such as Jadro catchment and Ombla underground accumulation.]]></summary_en></project><project>
<id>2505</id><title_hr><![CDATA[Urbanizam naslijeđa - Urbanistički i prostorni modeli za oživljavanje i unaprjeđenje kulturnoga naslijeđa]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1458</user_id><user_firstLast_name>Mladen Obad Šćitaroci</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-2984</code><acronim><![CDATA[HERU]]></acronim><duration></duration><status>Prekinut</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Arhitektura i urbanizam, </scie_field_hr><scie_field_en>Architecture and Urban Environment, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Arhitektonski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Architecture]]></institution_en><team_members_id>3237</team_members_id><team_members_names><![CDATA[ Doktorand: Nikola Matuhina ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Cultural Heritage, Urban Planning, Spatial Planning, Heritage Enhancement, Heritage Revival]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Croatia’s urban heritage is at least 25 centuries old. Examples of cultural/architectural and landscape heritage in Croatia are numerous, valuable and diverse. Part of this heritage is recognised worldwide and is protected by UNESCO. Croatia’s most valuable heritage is protected at a national level, although a part of it has, as yet, not been recognised. For various reasons the numerous examples of Croatian heritage are in a poor condition and decaying because they don’t have a permanent use and are not included in the life of cities and towns, despite being formally protected.In former research project, Urban and Landscape Heritage of Croatia as Part of European Culture, cultural heritage was researched in an attempt to present its values and traits as part of Croatia’s national identity and culture. The new project proposal partly supplements previous project thematically and uses results of this research, but the focus of research is on the creative, sustainable and responsible usage of urban, architectural and landscape heritage, which is a non-renewable resource. Contemporary attitudes of conservationists on the holistic protection based on international conservation documents connect protection with urban and regional planning through the concept of sustainable development. The aim of proposed research is to affirm heritage as an active space and spatial resource, to include it in future life and to allow it to be the initiator and active participant in sustainable spatial, social and cultural, economic and touristic development.The research will be based on the selected case studies for each type of cultural heritage. The aim is to define spatial criteria, methods and models for revitalisation and for the implementation of new projects within cultural heritage which may contribute to their enhancement. The project results (criteria, methods, models) will be applied in spatial and urban planning and conservation practices, and will be of far-reaching impact.]]></summary_en></project><project>
<id>2506</id><title_hr><![CDATA[Nekovalentne interakcije u dizajnu novih fotoosjetljivih molekula]]></title_hr><title_en><![CDATA[]]></title_en><user_id>243</user_id><user_firstLast_name>Davor Margetić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-1851</code><acronim><![CDATA[NoncoPhoto]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>17759</team_members_id><team_members_names><![CDATA[ Doktorand: Mateja Đud ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[physical-organic chemistry, green chemistry, synthesis, computational chemistry, organic materials]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Project addresses two key research objectives in the European Union: energy and environment conservation. The scientific approach is based on a combination of theoretical and experimental knowledge and experience of collaborators, and includes quantum-chemical calculations and molecular modelling in the molecular design, chemical synthesis and physico-chemical characterisation of molecules.The aim of project is to study fundamental physico-chemical properties of supramolecular systems built by non-covalent interactions (NC) - hydrogen bonding and metal-ligand coordination. The objectives are: a) Synthesis and structural characterization of functionalized bis-chromophoric molecular systems possessing guanidine, (thio)urea and carboxylate functionalities by employment of novel environmentally friendly synthetic methods; b) Detailed insight into the fundamental mechanisms how NC bonds mediate excited energy-transfer processes from one chromophore to another within assemblies; c) Analysis of influence of guanidine and (thio)urea functionalities and their anion complexation on the spectroscopic properties; d) Study of novel assemblies based on NC interactions and influence of different media; e) Development of model heterogeneous photo-responsive catalysis materials; f) Construction of complex multichromophoric supramolecular assemblies.Results of fundamental studies carried out within this project will enrich the understanding of physico-chemical factors in electron transfer processes in supramolecular systems constructed of chromophoric pairs employing the non-covalent bonding. Expected results will enable design of novel photoactive systems which could be applied in the technological development including sensors, fluorescent probes in biomedicine, organic photovoltaics, molecular electronics and heterogeneous catalysis.]]></summary_en></project><project>
<id>2508</id><title_hr><![CDATA[Višeskalno numeričko modeliranje deformiranja materijala od makro do nanorazine]]></title_hr><title_en><![CDATA[]]></title_en><user_id>927</user_id><user_firstLast_name>Jurica Sorić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-2938</code><acronim><![CDATA[MNumMacroNano]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, </scie_field_hr><scie_field_en>Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>17578</team_members_id><team_members_names><![CDATA[ Doktorand: Filip Putar ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Engineering materials, bilogical tissues, multiscale modeling, finite element  method, meshless method, damage modeling, molecular dynamics]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Many engineering materials as well as biological tissues have a heterogeneous structure particularly when they are observed at microlevel. In order to assess structural integrity as well as to predict structural lifetime, an analysis at microlevel is required. In recent years, a special attention has been directed to the investigation of relations between macroscopic properties of materials and their microstructure as well as to perform a link to atomistic scale. Since classical continuum mechanics cannot consider structural effects in the material at the micro- and nanolevel, multiscale techniques are developed that model material deformation responses at multiple levels using appropriate numerical procedures. Deformation responses of arteries will be considered by using multiscale computational strategy too. A special attention will be directed toward the mathematical modeling of arterial growth and remodeling, which could help physicians to track certain cardiovascular diseases and predict their development. For modeling of engineering materials, a new micro-macro numerical procedure based on the second-order computational homogenization approach employing nonlocal continuum theory will be proposed. Both finite element and meshless spatial discretization will be applied. The damage evaluation at the microlevel which may lead to macroscopic fracture will be modeled. Here the damage evaluation law based on the computational averaging procedure will be used and the modeling at atomistic scale will be performed in the very narrow domain of localization. In the atomistic modeling using molecular dynamics, a special attention will be directed to the coupling of atomistic domain with the discretized continuum domain. An approach inspired by the quasicontinuum and bridging domain will be proposed. All results of the research will be tested by the modeling deformation responses of realistic materials.]]></summary_en></project><project>
<id>2509</id><title_hr><![CDATA[Optimization of Automatic Transmission Shift Control   (Optimiranje upravljanja promjenom stupnjeva prijenosa automatskog mjenjača)]]></title_hr><title_en><![CDATA[]]></title_en><user_id>11149</user_id><user_firstLast_name>Joško Deur</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-2348</code><acronim><![CDATA[]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, </scie_field_hr><scie_field_en>Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>17751</team_members_id><team_members_names><![CDATA[ Doktorand: Vanja Ranogajec ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>2510</id><title_hr><![CDATA[FP7-ICT &#39;&#39;CADDY – Cognitive Autonomous Diving Buddy&#39;&#39;]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5962</user_id><user_firstLast_name>Nikola Mišković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-4651</code><acronim><![CDATA[]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>17737</team_members_id><team_members_names><![CDATA[ Doktorand: Filip Mandić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>2511</id><title_hr><![CDATA[Otvaranje obrazovanja kroz učenje unutar i izvan škola i kolaboraciju na mobilnim tablet računalima]]></title_hr><title_en><![CDATA[]]></title_en><user_id>151</user_id><user_firstLast_name>Ivica Botički</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-9536</code><acronim><![CDATA[SCOLLAm]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>3612</team_members_id><team_members_names><![CDATA[ Doktorand: Tomislav Jagušt ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[seamless learning, mobile learning, technology enhanced learning, collaborative learning, informal learning, educational technology]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[This project explores the potential of using mobile technology for seamless and mobile learning in Croatia and proposes a technologically innovative mobile learning platform named SCOLLAm. Being one of the first scientific mobile learning projects in Croatian schools, it explores both technology and pedagogies through two studies leveraging tablet computers in Croatian classrooms. In the first study, SCOLLAm will be deployed in a primary school to support new seamless and collaborative lessons in and across the existing subjects. In the second study, augmented mobile learning technology and the accompanying digital lessons will be used as a tool to support seamless and collaborative learning in a vocational school. These studies seek to stimulate and explore the effectiveness of mobile learning in Croatian schools in a strictly scientific manner, by engaging in digital mobile lesson co-design with the school teachers. The project will leverage experience from mobile learning research groups from Singapore, Sweden and USA in order to develop a new set of tools and lessons suitable for Croatian educational system. In order to move away from the tools typically targeting one platform and providing only limited adaptation mechanisms with virtually no learning analytics, one of the project objectives is the design, development and deployment of a scalable, adaptive and analytics driven platform SCOLLAm. Through the designed studies, produced open localizable educational resources and the SCOLLAm platform, we expect to see that the participants benefit from the introduction and use of mobile technology and applications through increased learning, collaboration skills and self-directedness, and acquire 21st century skills needed in their further education and life.]]></summary_en></project><project>
<id>2512</id><title_hr><![CDATA[Evocirani potencijali moždanog debla i testiranje autonomnog živčanog sustava kao metode procijene progresije bolesti u bolesnika s klinički izoliranim sindromom]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1081</user_id><user_firstLast_name>Mario Habek</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-9971</code><acronim><![CDATA[BACIS]]></acronim><duration></duration><status>Prekinut</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Clinical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>17860</team_members_id><team_members_names><![CDATA[ Doktorand: Luka Crnošija ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[clinically isolated syndrome, multiple sclerosis, evoked potentials, autonomic nervous system testing, brainstem]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[About 85% of patients have onset of MS with a relapse, which is known as a clinically isolated syndrome (CIS). Several studies have shown that infratentorial lesions are related to conversion rate and long-term prognosis for patients with CIS and thus may help to identify patients at high risk for earlier occurrence of clinically relevant disability. Bearing in mind the poor correlation between clinical symptoms and MRI findings there is a need for ancillary tools in the evaluation of brainstem pathology in MS. The aim of the current study is to evaluate the role of the brainstem evoked potentials score (bilateral AEP, bilateral ocular and cervical VEMP and bilateral tongue SSEP), the modified evoked potentials score (combination of brainstem evoked potentials score and VEP and SSEP of the median and tibial nerve) and standardized autonomic nervous system testing (Composite Autonomic Severity Score (CASS)) in the prediction of conversion from CIS to MS and accumulation of future disability. After 24 months of follow-up, this study could reveal the prognostic value of the brainstem EP score, modified EP score and CASS in patients with CIS on a number of parameters including: time until second relapse, accumulation of disability, accumulation of MRI lesions in the first 6 months, time to conversion from CIS to MS according to the 2010 revision of the McDonald criteria, number of relapses in the first 2 years of follow up. It can be presumed that the brainstem EP score and CASS score as direct and indirect measures of brainstem dysfunction, respectively will prove as reliable markers of future disability of CIS and MS patients. As a consequence, this would allow us to start more appropriate treatment in a subset of patients with higher probability of worse outcome.]]></summary_en></project><project>
<id>2513</id><title_hr><![CDATA[Diracovi operatori i teorija reprezentacija]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5573</user_id><user_firstLast_name>Pavle Pandzic</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-9187</code><acronim><![CDATA[representations]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>17808</team_members_id><team_members_names><![CDATA[ Doktorand: Karmen Grizelj ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Harish-Chandra modules, Dirac operators, cohomology, Dirac induction, branching problems]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Dirac operators were introduced into representation theory by Parthasarathy in the 1970s. In the 1990s, Vogan conjectured a strengthening of Parthasarathy&#39;s Dirac inequality, which relates the cohomology of the Dirac operator to the infinitesimal character of the representation. This conjecture was proved in a joint paper with Huang . In further research, in part joint with various collaborators (Barbasch, Huang, Kang, Mehdi, Protsak, Renard, Somberg, Zhu) , we related Dirac cohomology to other kinds of cohomology, calculated it explicitly for many interesting representations, and studied algebraic Dirac induction, a construction of representations with given Dirac cohomology. The proposed project will continue this research in several directions: 1) the study of representations obtained by Dirac induction, in particular the discrete series representations (doctoral research of Ana Prlić). 2) applying Dirac cohomology to problems of restricting representations. Some instances of this have been studied with Huang-Zhu and with Somberg. 3) trying to strengthen the Dirac inequality, which should have implications for the study of unitary representations. Some preliminary work on  the convex hull conjecture of Salamanca-Vogan has been done with Renard. 4) calculating the Dirac cohomology of  unipotent representations. Some cases of this have been obtained jointly with Barbasch. This could lead to better understanding of characters of unipotent representations, which is related to the Assem conjecture. It would also be interesting to calculate the Dirac cohomology of unitary highest weight modules. Other topics we plan to cover include studying translation principle for Dirac index (joint with Mehdi and Vogan); studying n-cohomology and BGG resolutions using Penrose transforms (joint with Soucek);  studying some abstract homotopy and homology theory, with applications to tensor categories of representations (doctoral research of Matija Bašić).]]></summary_en></project><project>
<id>2514</id><title_hr><![CDATA[Matematičko modeliranje, analiza i računanje s primjenama na kompleksne mehaničke sustave]]></title_hr><title_en><![CDATA[]]></title_en><user_id>2945</user_id><user_firstLast_name>Zlatko Drmač</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-5570</code><acronim><![CDATA[MMACACMS]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>17823</team_members_id><team_members_names><![CDATA[ Doktorand: Ivana Šain ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[scientific computing, complex mechanical systems, eigenvalue problems, model reduction, distributed control, high perfomance scientif computing]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[This proposal is focused on functional and numerical analysis of mathematical models of selected complex mechanical systems from mathematical physics and engineering, with particular emphasis on the development of numerical methods and robust algorithms for computing. Such operator theoretic models are particularly amenable to be treated algebraically in the context of efficient and robust computational procedures of modern numerical linear algebra. The themes include adaptive (interior penalty) discontinuous Galerkin method in the penalty based formulation of the model for the complex mechanical system (e.g. stent), and vibration analysis for powertrains (car industry).  In a related topic of vibration control, we study distributed control using dynamic multipliers from the dissipativity theory.  In the frequency domain, we consider the problems of system identification and model order reduction posed as problems of rational approximation in the Hardy space H2. For all considered problems, we devise numerical algorithms and identify core numerical linear algebra computational tasks for which we plan to develop robust algorithms. These include Arnoldi-type eigensolver for both linear and quadratic large scale eigenvalue problems, and high accuracy algorithms for structured matrices of paired Cauchy structure. All developed algorithms will be delivered also as high performance mathematical software.]]></summary_en></project><project>
<id>2516</id><title_hr><![CDATA[Promjene u kristaliničnim materijalima izazvane ionskim snopovima MeV-skih energija]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4589</user_id><user_firstLast_name>Stjepko Fazinić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-4153</code><acronim><![CDATA[MIOBICC]]></acronim><duration></duration><status>Prekinut</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>17802</team_members_id><team_members_names><![CDATA[ Doktorand: Roman Kosanović ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[MeV Ion Beams, Stopping Power, Ion Beam Modification of Materials, Ion Beam Analysis, Ion Beam Channeling, IBIC, RBS, PIXE, PIGE]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[In the recent years MeV ions have been extensively utilized as indispensable powerful tool in a wide range of materials science research. Ions are very efficient in creating numerous ionizations on their path through the material by ejecting/exciting electrons (electron stopping) and in creating vacancies by recoiling the whole atoms (nuclei) from their lattice sites (nuclear stopping). Therefore, irradiation of materials with energetic ion beams is considered as a) an efficient tool to alter materials physical, chemical, electrical and optical properties and b) a sensitive probe that can be used to characterise materials using some of the Ion Beam Analysis (IBA) methods. Understanding of complicated dynamical processes that lead to structural modifications of materials requires the knowledge of experimental data related to kinematics of defects during and after irradiation. Therefore the goal of the present proposal is experimental study of the time evolution of radiation induced changes induced by energetic (MeV) ion beams and their characterization using the RBI Tandem Accelerator Facility. The focus will be on studying: (i) influence of electronic stopping and related nanostructuring of materials by ion track methodology; (ii) influence of nuclear stopping to radiation damage and amorphization in crystals, including crystalline and functional materials of interest for future fusion reactors; (iii) charge transport properties in crystalline materials, focusing on novel semiconductor materials for radiation detection.  Experimental methodology relies mostly on the unique RBI dual-beam end station that will be used for ion beam irradiations and simultaneous characterization of induced changes using IBA methods like RBS and PIXE in channelling mode, ERDA, NRA and PIGE, as well as IBIC (Ion Beam Induced Charge).]]></summary_en></project><project>
<id>2517</id><title_hr><![CDATA[Uloga receptora autofagije u selektivnom uklanjanju mitohondrija]]></title_hr><title_en><![CDATA[]]></title_en><user_id>62</user_id><user_firstLast_name>Ivana Novak Nakir</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-9538</code><acronim><![CDATA[AutoMito]]></acronim><duration>08.01.2015 - 26.05.2021</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Split School of Medicine]]></institution_en><team_members_id>17855</team_members_id><team_members_names><![CDATA[ Doktorand: Mija Marinković ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[autophagy, mitochondria, mitophagy, receptor, neurodegeneration, cancer]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Autophagy is cellular degradation pathway essential for cell survival, development and differentiation. Its digestive property has been shown important in different pathologies including cancer, neurodegeneration and pathogen removal. Discoveries of specific autophagy receptors have opened a new chapter in the autophagy field. Of great interest is the removal of damaged or excess mitochondria through specialized autophagy- mitophagy. Together with colleagues, I have identified and characterized mitochondrial proteins Nix/Bnip3L and Bnip3 as a mitophagy receptors for recruiting the autophagic machinery to damaged mitochondria and help their elimination (Novak et al, 2010; Zhu et al, 2013). We demonstrated that receptors mediate mitochondrial clearance during reticulocyte differentiation. Our goal is to further study autophagy receptors and proteins associated with mitochondrial clearance to better understand the role of mitophagy and its mechanism. We will study: (1) phosphorylation and dimerization of receptors and the consequences of this events on mitophagy progression; (2)factors that regulate tight connection of apoptosis and mitophagy; (3)potential interplay between mitophagy receptors and other mitophagy-related proteins, like  E3-ligase Parkin and kinase PINK1; (4)the effects of mitophagy on cancer development. To reach our goals we will use established methodology in our laboratories including protein identification and interaction techniques (Western blot, IP, GST-pull down, RNAi), immunofluorescent microscopy, mass spectrometry, ITC and NMR. All experiments will be performed using cultured cells. This project proposal has a high capacity to generate very interesting data with high possibility for publications in top scientific journals. Fundamentally, generated data will help to understand the physiological and pathological conditions, such as neurodegeneration and cancer and allow us to manipulate mitophagy to fight diseases.]]></summary_en></project><project>
<id>2519</id><title_hr><![CDATA[Europski registar za djecu oboljelu od upalnih bolesti crijeva]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5694</user_id><user_firstLast_name>Sanja Kolaček</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-7791</code><acronim><![CDATA[]]></acronim><duration></duration><status>Prekinut</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Clinical sciences, </scie_field_en><institution_hr><![CDATA[Ništa od navedenog]]></institution_hr><institution_en><![CDATA[Nothing from this list]]></institution_en><team_members_id>17781</team_members_id><team_members_names><![CDATA[ Doktorand: Lana Njavro ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>2520</id><title_hr><![CDATA[Razvoj voltametrijskih metoda za karakterizaciju prirodnih antioksidansa]]></title_hr><title_en><![CDATA[]]></title_en><user_id>442</user_id><user_firstLast_name>Šebojka  Komorsky-Lovrić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-2282</code><acronim><![CDATA[DVMCNA]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>17762</team_members_id><team_members_names><![CDATA[ Doktorand: Lara Čižmek ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[voltammetry, antioksidans, radicals, squave wave, simulations]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Oxidant is an ion or a compound that reacts with a certain component of a living cell and oxidizes it. The reactive oxygen species produced in cells include hydrogen peroxide, hypochlorous acid, hydroxyl radical and superoxide anion. Antioxidant is a foreign substance that reacts with the oxidant faster than the components of the cell. An imbalance between oxidants and antioxidants in favour of the oxidants is termed oxidative stress. Antioxidants act as free radical scavengers and therefore can lower the risk of numerous degenerative diseases by preventing damages caused by free radicals. Fruits and vegetables are the major sources of antioxidants in human diet. Several natural compounds found in food, such as polyphenols, vitamins A and E, and some carotenoids, have been found to show excellent antioxidant activity. Chlorophylls and their derivatives have also been reported to possess this activity. However, literature is still scarce regarding their antioxidant properties. It is known that the amount of each antioxidant in fruits, vegetables and their derivatives is strongly influenced by numerous factors such as agro-technical processes, environmental conditions, processing factors and storage conditions. Continuous monitoring of antioxidant capacity of plant-based foods through different phases, from cultivation to storage, is needed to maintain or even improve the beneficial properties of food. The goal of this project is to develop several cyclic multi-pulse voltammetric techniques for the characterization of natural antioxidants and to apply them in routine analysis of food quality. Experimental results will be explained by the comparison with the theoretical simulation of responses of various electrode mechanisms of independent and conjugated multiple redox centers.]]></summary_en></project><project>
<id>2521</id><title_hr><![CDATA[Aproksimacija ovisna o konfiguraciji u nelinearnoj analizi konstrukcija metodom konačnih elemenata]]></title_hr><title_en><![CDATA[]]></title_en><user_id>527</user_id><user_firstLast_name>Gordan Jelenić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-9680</code><acronim><![CDATA[CANFAS]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Temeljne tehničke znanosti, </scie_field_hr><scie_field_en>Basic engineering sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Građevinski fakultet u Rijeci]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Civil Engineering]]></institution_en><team_members_id>17756</team_members_id><team_members_names><![CDATA[ Doktorand: Sara Grbčić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[non-linear structural analysis, finite-element method, configuration-dependent approximation, beams, shells, dynamics]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[This proposal explores the configuration-dependent interpolation as a novel, unorthodox and remarkably promising expansion of the framework within which the non-linear finite-element method has been traditionally contained. The basic idea underlying the project stems from an apparent disparity between the rather advanced extensions of the traditional linear finite-element principles to non-linear problems and the fact that the key finite-element concept – that of interpolation of the unknown functions – is surprisingly kept mostly constant, i.e. configuration-independent. Enabling the finite-element approximation to become configuration-dependent is motivated by the existing need to improve the current non-linear finite-element procedures, in particular for mechanical problems defined on non-linear manifolds. This principle is presented as the general concept providing viable novel development paradigm with obvious benefits for a wider class of mechanical problems. The configuration-dependent approximation to be designed shall obey the essential convergence requirements, with its extra flexibility (arising from the potential of the new approximation to vary with the configuration) employed to improve the solution in some clearly defined manner. In particular, during the design process, the following two basic principles will be consistently adhered to:(i) In the limiting case where the non-linear mechanical problem becomes linear, the configuration-dependent approximation sought must coincide with a known reference interpolation for linear analysis.(ii) In a general non-linear situation, the configuration-dependent approximation should preserve a set of selected mechanical or mathematical properties of equilibrium or motion defined beforehand.In this way, a variety of finite-elements for static and dynamic analysis will be derived.]]></summary_en></project><project>
<id>2522</id><title_hr><![CDATA[Thymistem, (FP7- Health 2013.1.4-1)  ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>498</user_id><user_firstLast_name>Mariastefania Antica</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-2010</code><acronim><![CDATA[]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>17772</team_members_id><team_members_names><![CDATA[ Doktorand: Josipa Skelin ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>2525</id><title_hr><![CDATA[Algoritmi za analizu slijeda genoma]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1480</user_id><user_firstLast_name>Mile Šikić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-2255</code><acronim><![CDATA[AGESA]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>18950</team_members_id><team_members_names><![CDATA[ Doktorand: Robert Vaser ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[genome sequence, DNA sequence alignment, RNA-seq mapping, database search, algorithms, GPU]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Twenty years ago, sequencing the human genome was one of the most ambitious science projects ever attempted. Today, DNA and RNA sequencing are now key components of research carried out in many laboratories. The total amount of available genomic data is increasing approximately tenfold every year, a rate much faster than Moore’s Law for computational processing power. The exponential growth of genomic datasets leads to a situation, where computing power becomes a critical issue.The overarching goal of the project is to develop accurate, fast algorithms and tools for analyzing the whole genome-sequencing data. The emphasis of the project is on the output data from the third-generation of sequencing machines that produce longer, more error-prone sequence reads. The basis of the project are sequence alignment algorithms, graph algorithms and signal processing methods. They will be implemented for DNA sequence assembly, sequenced RNA data and sequence similarity database search. The algorithms should feasibly handle data obtained from mammalian and plant genomes (sizes greater than one billion base pairs). Special emphasis will be put on multi-core, many-core and intra-core parallelism. Additionally, the algorithms should provide good scalability over the available underlying computational architecture. All implementations of algorithms will be performed in C/C++. The research will result in the development of novel algorithms tailored to specifications of current and future long-read sequencing data. The implemented methods will further the state-of-the-art of sequence similarity database search, RNA-seq mapping and DNA assembly, ideally providing researchers with methods that return results in feasible time with limited computational resources. This, in turn could affect the current practices of genomic research; help designing new medical strategies and enable faster and more accurate analyses and diagnoses. ]]></summary_en></project><project>
<id>2526</id><title_hr><![CDATA[MOLEKULARNI MEHANIZMI POVEĆANJA OSJETLJIVOSTI NA PROTUTUMORSKE LIJEKOVE STANICA KARCINOMA DOJKE I MELANOMA ČOVJEKA UTIŠAVANJEM INTEGRINA]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1211</user_id><user_firstLast_name>Andreja Ambriović Ristov</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-9922</code><acronim><![CDATA[INSILCELL]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>420</team_members_id><team_members_names><![CDATA[ Doktorand: Ana Dekanić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[breast cancer, melanoma, signalling pathways, anticancer drug resistance, focal adhesion, migration, invasion]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The recognition of molecular mechanisms involved in drug resistance may improve basic knowledge of signalling pathways involved in resistance to anticancer drugs and also improve outcomes in patients with drug-resistant cancers that have poor prognosis, such as triple negative breast cancer (TNBC) and metastatic melanoma. Integrins are cell surface molecules that mediate sensitivity to anticancer drugs, migration and invasion, and therefore represent a suitable target for therapy. This proposal investigates the molecular mechanism behind knockdown of integrins alpha v beta 3, alpha v beta 5, alpha v beta 6, alpha 3 beta 1, alpha 4 beta 1 and alpha 5 beta 1 using integrin subunit specific siRNAs (beta 3, beta 5, beta 6, alpha v, alpha 3, alpha 4 or alpha 5) and the ability of such a treatment to sensitise TNBC and melanoma cell lines to anticancer drugs paclitaxel, vincristine and cisplatin. Our next goal is to identify how specific integrin knockdown influences cell migration and invasion. The focal adhesions (FA) are sites of attachment between cells and extracellular matrix which may mediate differential cell responses by variation of FA protein composition. Therefore, the FA protein composition will be investigated before and upon integrin silencing using proteomics methodology. We will monitor formation and temporal evolution of FA in living cells during spreading or migration using reflection interference contrast microscopy (RICM). On the basis of these data, several signalling pathways will be proposed and their involvement in sensitivity to anticancer drugs, migration and invasion will be experimentally verified. Our data will contribute to the knowledge on integrin signalling pathways, structure and function of focal adhesions. The understanding of integrin pathways involved in sensitivity to anticancer drugs, migration and invasion processes may provide novel insights into biology of these cancer cells and identify new target molecules in TNBC or melanoma.]]></summary_en></project><project>
<id>2527</id><title_hr><![CDATA[Life-Strategies and Survival Strategies of Households and Individuals in South-EastEuropean Societies in the Times of Crisis]]></title_hr><title_en><![CDATA[]]></title_en><user_id>7730</user_id><user_firstLast_name>Inga Tomić-Koludrović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-7620</code><acronim><![CDATA[]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Sociologija, </scie_field_hr><scie_field_en>Sociology, </scie_field_en><institution_hr><![CDATA[Institut društvenih znanosti Ivo Pilar]]></institution_hr><institution_en><![CDATA[Institute of Social Sciences Ivo Pilar in Zagreb]]></institution_en><team_members_id>17800</team_members_id><team_members_names><![CDATA[ Doktorand: Augustin Derado ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>2528</id><title_hr><![CDATA[Elektrokemijski superkondenzator visoke snage i velikog sadržaja energije za primjenu u električnim vozilima]]></title_hr><title_en><![CDATA[]]></title_en><user_id>961</user_id><user_firstLast_name>Zoran Mandić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-7033</code><acronim><![CDATA[ESUP-CAP]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Kemijsko inženjerstvo, </scie_field_hr><scie_field_en>Chemical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet kemijskog inženjerstva i tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Chemical Engineering and Technology]]></institution_en><team_members_id>17810</team_members_id><team_members_names><![CDATA[ Doktorand: Denis Sačer ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Supercapacitors, electrochemical energy sources, electric vehicles, renewable energy, carbon electrodes, conducting polymers]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[In the context of renewable and “clean” energy sources, the main aim of the present project is to provide a technology output for the novel, high power-high energy electrochemical supercapacitor device that could be implemented in hybrid electric vehicles. The project addresses an interdisciplinary research and combines fundamental and applied research activities in chemical, electrical and environmental engineering fields. The highest possible scientific and technological impact of the project is supposed to be ensured by joining of the human and experimental resources of several different Croatian’s groups. The novel, high power-high energy electrochemical supercapacitor device will be based on hybridization of two different types of electrodes (double-layer and pseudo-capacitive) in a respective electrolyte. Various forms of carbon and carbon based binary and ternary composites with transition metal oxides and/or conducting polymers will be tested as negative and positive electrodes, respectively. For being competitive in the area of energy storage, the tested electrodes should fulfil the requirements of high specific capacitance, long cycle-life, good charge/discharge efficiency, low self discharge and adequate operating voltage. The project is planned to be realized mostly on the basis of fundamental experimental research directed towards increasing of the basic knowledge comprising choice of material, proper design of electrodes and careful elucidation of all underlying physical and chemical processes at active electrode/electrolyte interfaces. The results of fundamental experimental research will be utilized for selection of proper electrodes, their arrangement into electrochemical supercapacitor device, optimization of device to the energy content and power ability, testing of device in practical environment and implementation of device into hybrid electrical vehicle. ]]></summary_en></project><project>
<id>2530</id><title_hr><![CDATA[Epigenetička regulacija glikozilacije immunoglobulina G]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5416</user_id><user_firstLast_name>Vlatka Zoldoš</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-1892</code><acronim><![CDATA[EpiGlycoIgG]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>17847</team_members_id><team_members_names><![CDATA[ Doktorand: Vanja Tadić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[DNA methylation, Epigenetics, Histone modifications, IgG, Protein glycosylation, TALENS]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[IgG is one of the main effectors of the immune system. Contrary to antigen binding properties which are defined by nucleotide sequence for its Fab part, effector functions of IgG are mostly regulated by Fc glycosylation, which is regulated by complex interplay of dozens of genes in the IgG glycosylation pathway and different environmental factors. Different clones of B lymphocytes have defined patterns of glycosylation, indicating temporal stability in the glycosylation pathway. DNA CpG methylation is the most stable epigenetic modification and is thus the most prominent candidate for “fixation” of the IgG glycosylation profile in different clones. Our past and current genome wide association studies (GWAS) are identifying complex genetic network which regulates IgG glycosylation. In this project we will use several complementary experimental approaches to identify genes and epigenetic regulatory mechanisms which regulate IgG glycosylation. IgG glycosylation is relevant in numerous diseases, including autoimmune diseases, inflammatory diseases and cancer. Several epigenetic drugs are already used to treat cancer, and many others are developing. Understanding of the role of the epigenetic regulation in IgG glycosylation will provide new targets for the development of new epigenetic drugs and new biomarkers for patient stratification. ]]></summary_en></project><project>
<id>2532</id><title_hr><![CDATA[Bioinspirirani materijali - mehanizmi nastajanja i interakcija]]></title_hr><title_en><![CDATA[]]></title_en><user_id>922</user_id><user_firstLast_name>Damir Kralj</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-2469</code><acronim><![CDATA[Bio-Mat-Form]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>17878</team_members_id><team_members_names><![CDATA[ Doktorand: Lara Štajner ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Biomineralization, Calcium Phosphates, Calcium Carbonates, Precipitation, Model organic molecules]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Prosperity of modern society at large extent relies on the design of new and advanced materials. Many classes of organic, inorganic or hybrid materials are produced by process of precipitation (crystallization) in which the size, morphology, chemical and structural composition could be tuned by the strict control of formation conditions. Process by which living organisms produce hard tissues is known as biomineralization and such tissues are, actually, the organic-inorganic composites. In comparison to their geological analogues, biominerals have the superior mechanical and chemical properties that are a consequence of just a minor presence of extracellular matrix proteins or polysaccharides, as well as of the specific confined environment in which the process occur. In addition, such materials are produced from aqueous systems, chemically neutral precursors, at low temperature and pressure, thus inspiring the scientists investigating the biomimetic syntheses routes for design of functional materials for advanced application.In order to contribute to the understanding of basic interactions between the mineral phases and complex macromolecules, underlying biomineralization, we propose the investigations in which the representative inorganic salts (calcium carbonates & phosphates) will be precipitated in a presence of simple and representative organic molecules (acidic and hydrogen bonding amino acids and custom-designed small peptides) while the complexity of systems will be systematic increased by confining the precipitation in polysaccharide hydrogel or synthetic vesicular microenvironment. Particular attention will be paid on a role of the amorphous and other precursor phases on formation of stable modifications relevant for biomineralization. Besides the precipitation kinetic analyses, the advanced characterization techniques (HR-TEM, EPR, confocal microscopy) will be applied in order to reveal the mechanisms of organic molecules – mineral surface interactions.]]></summary_en></project><project>
<id>2534</id><title_hr><![CDATA[Razvoj naprednih energetski učinkovitih struktura upravljanja generatorom sa stalnim magnetima bez mjernog člana ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5949</user_id><user_firstLast_name>Damir Sumina</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-8519</code><acronim><![CDATA[PMGEFC]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>17782</team_members_id><team_members_names><![CDATA[ Doktorand: Tin Bariša ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[permanent magnet generator,  wind power generation, back-to-back converter, energy efficiency,  sensorless control,]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Renewable energy sources have been attracting great attention due to the cost increase, limited reserves and advanced environmental impact on fossil fuels. In the meantime, technology advancements, cost reduction and governmental incentives have made some renewable energy sources more competitive in the market. Among them, wind energy is the one of the fastest growing renewable energy sources. The conversion of the wind energy into electric energy is of a multidisciplinary nature, involving aerodynamics, mechanical systems, electric machines, power electronics, control theory, and power systems.The main goal of this project is to establish new research group which will improve the quality, performance and competitiveness of industrial sector in the field of wind power generation. The research group has already participated in the project for the development of advanced control structures for induction generator connected via back-to-back-converter to the grid in wind turbine application. As a step forward in innovation, research and development the research focus is set on permanent magnet synchronous generator (PMG) parameter identification, estimation of PMG rotor position using high frequency signal injection and speed estimation. Also, focus is on energy efficient based control method such as model predictive control of PMG. Advanced sensorless control algorithms for PMG will be developed and experimentally verified on the industrial laboratory model. Basic infrastructure for implementation and verification of developed algorithms exists in the Laboratory and for testing of advanced control structures on PMG laboratory model needs to be further upgraded. The final result will be the capability of research group for future cooperation with industrial partners for development of wind power generator systems and other generation systems.]]></summary_en></project><project>
<id>2535</id><title_hr><![CDATA[Postupci strojnog učenja za dubinsku analizu složenih struktura podataka]]></title_hr><title_en><![CDATA[]]></title_en><user_id>19111</user_id><user_firstLast_name>Ivica Kopriva</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-5945</code><acronim><![CDATA[DescriptiveInduction]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>17767</team_members_id><team_members_names><![CDATA[ Doktorand: Maria Brbic ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[machine learning, knowledge discovery, structured data, rule learning, FPGA]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[ Induction is a process of knowledge extraction from information contained in data. In our work we will concentrate on descriptive induction whose goal is to construct knowledge that enables human understanding of the data. Included are techniques for construction of user-interpretable models, segmentation of the corpus of examples, and detection of outliers. The methodology is relevant for the computer science fields known as intelligent data analysis, knowledge discovery from data, and data mining. At Rudjer Boskovic Institute we are developing machine learning algorithms for more than 15 years and we have successfully applied them in various domains including chemistry, biology, medicine, social sciences, economics, and manufacturing. With this project we want to extend the existing methodology and to implement novel techniques able to cope with data contained in complex structures. The main topic will be spatio-temporal structures but we will work also with networks of data, relational databases, and data contained in ontologies. Previous experience clearly demonstrates that complete transformation of information contained in structured data into a form that may enter the induction process is not a simple task. Our goal is to develop and implement systematic and general approaches for this conversion. The consequence will be explosion of generated data that must enter into the process of induction. Therefore, the second goal will be implementation of efficient algorithms for descriptive induction. The work includes development of novel algorithms for clustering and outlier detection in sets of unclassified examples and implementation of hardware for fast execution of rule learning algorithms. The third goal is application and evaluation of implemented algorithms in various real-life domains. The success of the complete project will be measured by the quality and usefulness of knowledge obtained in these applications.]]></summary_en></project><project>
<id>2537</id><title_hr><![CDATA[Uvjeti, resursi, neprijatelji i bioraznolikost: Sile koje oblikuju morske zajednice u plitkom Jadranskom moru]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1269</user_id><user_firstLast_name>Stewart Schultz</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-2216</code><acronim><![CDATA[COREBIO]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zadru]]></institution_hr><institution_en><![CDATA[University of Zadar]]></institution_en><team_members_id>17825</team_members_id><team_members_names><![CDATA[ Doktorand: Dubravko Pejdo ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[community ecology, fish, Posidonia, habitat, monitoring]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[This project is an investigation of the major drivers of fish community structure in the shallow Adriatic Sea of Croatia.  This information is crucial for the sustainable, scientific management of coastal ecosystems, as required by EU instruments such as the Habitats Directive, Marine Strategy Framework Directive, Water Framework Directive, and the Common Fisheries Policy.   The major questions asked are 1) What are the ecological baselines in Croatia in community structure?  2) How does anthropogenic activity (harvesting, coastal development) shift community structure from baseline?  3) How do marine protected areas maintain functional communities?  4) How is community structure changing over time?   We will investigate these questions using innovative, non-destructive techniques for quantifying fish abundance and size distribution, and benthic habitat quality.  These techniques include lure-assisted, underwater visual census which was originally developed in the Schultz laboratory; baited, underwater video; and DGPS-assisted, towed underwater video.  EU policies require that non-destructive methods for assessment and monitoring replace destructive harvest-based methods currently in widespread use, and these methods are among the most scientifically supported non-destructive methods currently available.  These methods will be used to quantify fish community structure and benthic habitat at all major MPAs and former MPAs in Croatia, to compare communities within MPAs to matched locations outside MPAs.   Matched locations will be chosen to test for specific anthropogenic drivers of community structure, such as high fishing pressure, coastal development, marine tourism, aquaculture, and terrestrial runoff.  These results will advance our basic understanding of coastal ecosystems, and will be crucial for satisfying Croatia&#39;s responsibilities as an EU citizen in MPA construction, management, and monitoring of marine resources.]]></summary_en></project><project>
<id>2538</id><title_hr><![CDATA[Promjenjivost Sunca i zvijezda]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4850</user_id><user_firstLast_name>Bojan Vršnak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-8294</code><acronim><![CDATA[SOLSTEL]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Geodetski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Geodesy]]></institution_en><team_members_id>6152</team_members_id><team_members_names><![CDATA[ Doktorand: Mateja Dumbović ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[solar activity, space weather, climate, heliosphere, sun-like stars, variable stars, binary stars, accretion discs, exoplanets, substellar companions]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The proposed four-year project connects solar physics, solar-terrestrial physics, heliospheric physics, space weather & climate, geophysics, and stellar physics. It is based on empirical/interpretative, theoretical/analytical, and theoretical/numerical approach, and concerns all astrophysical problems currently in focus of the research at the Hvar Observatory (HO) of the Faculty of Geodesy of the University of Zagreb. Thus, the proposed program is in a great deal determined by, and directed towards, effective exploitation of the observational capacities and manpower of HO. The project is divided into five thematic topics: 1) solar activity and eruptive phenomena in the solar atmosphere; 2) solar-activity impact on the Earth; 3) stellar eruptive activity; 4) radiation processes in solar and stellar atmospheres; 5) exoplanets and substellar companions. In the first topic special attention is devoted to the research of the physics of coronal mass ejections and solar flares, since they drive the most intense geomagnetic storms, as well as changes of radiation belts and ionosphere. The central issue of the second topic is the influence of the solar variability on the Earth climate. The third topic is devoted to stellar eruptive magnetic-field activity, aiming to provide a better understanding of the long-term evolutionary aspect of the solar activity. The fourth topic is an important subject not only for astrophysics, but also for plasma physics in general, since it provides an alternative view on plasma instabilities and emission processes. The fifth topic is a timely astrophysical theme, since it provides new insights into physics of planetary systems, and is very important subject for understanding of the solar-system formation and evolution.]]></summary_en></project><project>
<id>2540</id><title_hr><![CDATA[Nano-mreže kvantnih točaka u staklima: Od samouređenja do pretvorbe energije i pohrane vodika]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1362</user_id><user_firstLast_name>Maja Buljan</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-4610</code><acronim><![CDATA[NanoDeSign]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>17815</team_members_id><team_members_names><![CDATA[ Doktorand: Nikolina Nekić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Quantum dots, Self-assembly, Magnetron sputtering, Quantum dot crystal, Hydrogen storage, Energy conversion, Solar cell, Ion-beam irradiation]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The main goal of the project is to investigate the capabilities of the recently developed materials based on self-assembled quantum dots organized as nano-networks in glass matrices for application in energy-conversion and Hydrogen-storage devices. Two new self-assembly processes of Ge quantum dots in dielectric amorphous matrices and consequently novel material types have been discovered recently by our group.  We have performed intensive investigation of their structural properties since then, and we had found that they appear in many different shapes, internal structures and ordering types. One material can store large amounts of Hydrogen. However, only properties of Ge and SiGe quantum dots have been investigated, while all other materials and their properties are completely unknown. These materials are theoretically very suitable for applications, especially in photo-electric conversion and energy storage, so the investigations of their properties related to the applications are also very important.We intend to form a group which will be excellent in production, characterization and application of these materials. Precisely, we intend to (i) further investigate the observed self-assembly processes and develop new material types with interesting or extraordinary structural properties; (ii) determine the basic optical and electrical properties of these materials and (iii) produce simple devices based on these materials for energy conversion and storage.We expect preparation of new, applicative materials with exceptional properties, observation of unusual effects caused by specific structure, and preparation of efficient thin-film coatings for conversion and storage of Sun energy. These results could be of great relevance for the production of super-efficient energy-converting window glasses, as the method that we use for the preparation (magnetron sputtering deposition), is a standard technique for production of window coatings and low-emissivity glasses.]]></summary_en></project><project>
<id>2541</id><title_hr><![CDATA[Transporna, magnetska i termodinamička svojstva odabranih anorganskih i organskih materijala]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5009</user_id><user_firstLast_name>Ivan Kokanovoć</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-6755</code><acronim><![CDATA[TRANMAGTHERPROMAT]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>17743</team_members_id><team_members_names><![CDATA[ Doktorand: Filip Orbanić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Superconductivity, topological insulators,  metallic glasses,  nanocrystalline alloys, conducting polymers, ]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[This Project is centred on the physics of selected YBCO single crystals, HTSC, topological insulators, TI, metallic glasses, MG, nanocrystalline alloys, NCA, and conducting polymers, CP, and investigation of their transport, thermodynamic, thermoelectric, magnetic, superconducting and structural properties. The primary issue addressed in the field of HTSC is the existence of electron pockets in low magnetic fields   caused by charge density waves, CDW, in pure YBa2Cu3O6+x single crystals. We propose to measure the magnetisation and specific heat in the whole doping range  to extract the total density of states at the Fermi level and thereby determine the number of pockets.  At the same time we will look for thermodynamic signatures of the CDW phase transitions.  Other unresolved controversies which will be investigated include the doping evolution of the mean-field upper critical field and whether Gaussian superconducting fluctuations can account for the magnetisation and specific heat of both underdoped and overdoped YBa2Cu3O6+x single crystals at T>Tc. In the field of TI, we will investigate the thermoelectric properties of bismuth based chalcogenide (BiSbTeSe2) and 3D Dirac semimetals and to find the evidence of the linear dispersion and nontrivial topology of these materials. Our next aim is to achieve ferromagnetism in selected TIs; TlBi(S0.5Se0.5)2, PbSnTe and PbSnSe by doping with Mn or Fe and gain understanding of the mechanism responsible for the ferromagnetic ordering.   In the field of MG and NCA   the goal is to gain some insight into the glassy structure and mechanism involved in its crystallisation. In the field of organic conductors we intend to investigate PANI-DBSA (DBSA-dodecylbenzenesulfonic acid) thin film samples. A particular emphasis of the research will be the further development of novel apparatus to measure the magnetisation and specific heat of small single crystals which are often of the highest quality.  ]]></summary_en></project><project>
<id>2542</id><title_hr><![CDATA[Dubrovnik: Civitas et Acta Consiliorum, Vizualizacija razvoja kasnosrednjovjekovnog urbanog tkiva]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5998</user_id><user_firstLast_name>Danko Zelić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-6008</code><acronim><![CDATA[DUCAC]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Povijest umjetnosti, </scie_field_hr><scie_field_en>Art history, </scie_field_en><institution_hr><![CDATA[Institut za povijest umjetnosti]]></institution_hr><institution_en><![CDATA[Institute of Art History, Zagreb]]></institution_en><team_members_id>5555</team_members_id><team_members_names><![CDATA[ Doktorand: Matko Matija Marušić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[new archival data, urban development, changes of tissue, dissemination, comparative perspective, general public, new digital technologies]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The aim of the DUCAC project is to establish an international, Croatian-Italian group of urban history researchers that would participate in the work, research and discussions within the international community of humanities and social sciences. The project&#39;s main goal is to systematically investigate the unpublished 15th century archival records of Dubrovnik&#39;s three governing bodies (Great Council, Minor council and the Senate) in order to select, gather, interpret and publish data concerning urban spaces and buildings and to examine the relationships between Councils’ deliberations and the urban development. The results would be discussed within the comparative perspective regarding the similar topics of other European towns as well as disseminated within scientific community and general public. These objectives would be established using new digital technologies for the humanities - HGIS interactive database and 3D visual presentations of the related processes.]]></summary_en></project><project>
<id>2543</id><title_hr><![CDATA[Uloga biotičkih čimbenika na vitalnost poljskoga jasena (Fraxinus angustifolia Vahl.) u poplavnim šumama Hrvatske]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1128</user_id><user_firstLast_name>Davorin Kajba</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-1443</code><acronim><![CDATA[FRAXINPRO]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Šumarstvo, </scie_field_hr><scie_field_en>Forestry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet šumarstva i drvne tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Forestry and Wood Technology]]></institution_en><team_members_id>17430</team_members_id><team_members_names><![CDATA[ Doktorand: Ivan Andrić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Fraxinus angustifolia, vitality, biotic agents, floodplain forests, modelling]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Close to half of the Croatian flood plain forests (67 470 ha) are represented by narrow-leaf ash (Fraxinus angustifolia), covering 29 748 ha in major river basins. Respective welfare value of these forests amount to 6,4 billion €, 2,8 billion € being attributed exclusively to ash forests. Growing stock in narrow-leafed ash forests reaches 4,3 million m3, binding 11,8 million tons of carbon dioxide acting as an important carbon sink depository. Natural and artificial regeneration of ash stands is under direct impact of numerous biotic and abiotic factors, many of which seriously hamper the viability of ash. Insect pests, pathogenic fungi, large game ungulates and ruminantes and small rodent populations play dominant role in the complex processes of tree decline and stand deterioration. Additionally, in the course of recent Europe-wide dramatic spread of newly identified lethal disease on ashes (Chalara fraxinea), introduction of a highly damaging Emerald Ash Borer (Agrilus planipennis) on the eastern borders of Europe, and increased frequency of climatic extremes urge the need to intensify the research of this phenomena. Through an integrated, multidisciplinary approach, in the course of 4 years, the proposed research project targets on several critical aspects of aforementioned biotic detrimental factors analyzing them in the given area and time and aiming to provide a multitude of new details on the mechanisms of their impact. Modern methodological approach covers the following major research topics: presence, local impact and ash disease spread and host resistance tests; additive impact of ash defoliators in the course of recent decline and possibility to manage their populations via entomopathogenic organisms; the impact of small rodents on tree regeneration, acting also as an important human diseases reservoir; negative impact of large game in ash regeneration; geospatial and temporal analysis of major biotic influences in given forest communities. ]]></summary_en></project><project>
<id>2544</id><title_hr><![CDATA[Histološka, MRI i analiza genske ekspresije reorganizacijskih procesa u medijalnom (limbičkom) zidu ljudskog mozga tijekom razvitka]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3523</user_id><user_firstLast_name>Mario Vukšić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-1969</code><acronim><![CDATA[MEDCEREB]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>17812</team_members_id><team_members_names><![CDATA[ Doktorand: Vinka Kovačević ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[subplate, marginal zone, human brain development, immunohistochemistry, gene expression, in situ hybridization, MRI analysis, hippocampus, cingulum]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The salient feature of the human fetal cortex is the presence of the subplate zone (SP), a prominent, synapse rich compartment composed of „waiting“ afferents, loosely arranged axons, synapses, growth cones, migratory neurons, glial cells and extraordinary amount of extracellular matric molecules (ECM). The medial (limbic) cortical regions (areas involved in emotion and memory functions) develop a different laminar structure in comparison with lateral cortical regions. Unlike the lateral cortex, where the SP is a major site of neurogenetic events, in the medial archicortex marginal zone (MZ) seems to be a key zone for early molecular neuronal interactions, synaptogenesis and patterning of growing pathways. The goal of this project is to correlate developmental reorganization of major cellular (cell bodies, growing axons) components of the SP and the MZ in developing medial wall of the human cerebrum (cingulum, hippocampus, amygdala) by combining immunochistochemistry, in situ hybridization, transcriptome analysis with in vivo/in vitro MRI. Histological analysis wiil be performed on postmortem human brains, ranging from 10 postconceptional weeks (POW) to 6.5 years, to analyze the expression patterns of different developmentally regulated proteins in relation to synaptic, laminar, neuronal, glial and ECM development. These results will be correlated with in vivo/in vitro MRI findings obtained in age-matched fetuses, infants and children. In addition, we will also analyze publicly available gene expression database (Kang et al., 2011) to investigate the relationship between structural changes and spatio-temporal expression of specific candidate genes. For the selected candidate genes we will perform in situ hybridization and immunocytochemistry in order to elucidate in which cells are these genes expressed. The obtained data will be used for setting the baseline for studying developmental abnormalities characteristic for diverse neurological disorders]]></summary_en></project><project>
<id>2545</id><title_hr><![CDATA[Uloga disfunkcije lizosoma na nastanak neurodegenerativnih bolesti]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4828</user_id><user_firstLast_name>Silva Katušić Hećimović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-9815</code><acronim><![CDATA[]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>17865</team_members_id><team_members_names><![CDATA[ Doktorand: Kristina Dominko ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>2546</id><title_hr><![CDATA[Kruženje sumpora i ugljika u morskom i slatkovodnom okolišu]]></title_hr><title_en><![CDATA[]]></title_en><user_id>287</user_id><user_firstLast_name>Irena  Ciglenečki-Jušić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-7023</code><acronim><![CDATA[SPHERE]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>17873</team_members_id><team_members_names><![CDATA[ Doktorand: Ana  Cvitešić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[sulphur speciation, organic matter properties, nanoparticles in water environment, aerosols, global climate changes, extreme events, euxinia  ]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The SPHERE aims to study sulphur (S) and carbon (C) dynamics between different environmental compartments (atmosphere, water, sediment, biota) of the sea- and fresh-water environment including distribution between organic, inorganic, dissolved, colloidal and nanoparticulate fractions. S and C cycles in the aqueous environment are recognized as important factors for regulating global climate. Nowadays, human activities have vastly affected the S and C cycles. The aquatic ecosystem responses to likely changes in physical, chemical and socio-economic forcing induced by global climate changes, including warming, acidification, biodiversity modifications as well changes in frequency of extreme events (flooding, dust input, hypoxia-anoxia appearance) and by growing anthropogenic pressures will be considered under SPHERE. Effects of the main natural and anthropogenic forcing (extreme events, eutrophication, global changes) related with S and C dynamics will be studied.The SPHERE objectives are: 1) testing and improving existing methods and development of new methods essential for S and organic matter (OM) characterization in water and atmospheric environment; 2) to estimate exchanges and interactions of S and C with other natural and potentially toxic trace elements within and between the major environmental compartments; 3) to monitor and couple S and C dynamics under extreme events (stratification-destratification, hypoxia-anoxia, extreme atmospheric inputs); 4) to synthesize all obtained data for assessment of ecosystem vulnerability and ecological status, in line with water framework directive and national strategy. The SPHERE will be implemented in the period of 4 years through 5 workpackages: 1) OM properties and dynamics; 2) S speciation and dynamic; 3) S, C interaction with trace metals and importance of chalcogenide nanoparticles; 4) thermodynamic predictions for S and C distribution and dynamics; 5) project management.]]></summary_en></project><project>
<id>2547</id><title_hr><![CDATA[Višenamjensko očitavanje DNA / RNA sekundarne strukture molekularnim kemijskim senzorima]]></title_hr><title_en><![CDATA[]]></title_en><user_id>480</user_id><user_firstLast_name>Ivo Piantanida</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-9225</code><acronim><![CDATA[DNA/RNA-MolSense]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>17784</team_members_id><team_members_names><![CDATA[ Doktorand: Tamara Šmidlehner ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Molecular sensing, DNA/RNA, fluorescence, oligopeptide, nucleobase]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Molecular recognition of DNA/RNA is of fundamental importance e.g. for gene transcription and regulation, protein synthesis or cell-division. Small molecules selectively targeting specific DNAs or RNAs are therefore highly interesting not only to understand such processes in more detail but also for potential medicinal applications, as sensors or probes for fluorescence based bioimaging as well as for analytical purposes in isolated biosamples. Proposal is based on the collaboration between I. Piantanida and Prof. Dr. C. Schmuck (Germany), joined results in leading chemistry journals (Chemistry, Eur. J; 2010 and 2012, J. Am. Chem. Soc. 2012; Org. Biomol. Chem. 2011, Bioorg. Med. Chem. Lett. 2008). We want to design, synthesize and study highly selective probes for the sensing of DNA/RNA with emphasis on the multi-purpose probes: single molecules able to simultaneously differentiate by several highly sensitive spectrometric methods between the most common secondary structures of ds- DNA/RNA. For increased affinity and selectivity, we plan to test new, more efficient fluorophores (cyanine, phenanthridine, fluorescent nucleobases-Piantanida group) combined with pyrrole-guanidinium cations (Schmuck group) and explore structural diversity of the compounds, by combinatorial approach (solid phase synthesis) based on peptide backbone carrying recognition units/fluorophores. The interaction with DNA/RNA will be studied by Piantanida group (UV/Vis, fluorescence, CD/LD spectroscopy, DSC/ITC microcalorimetry), screening of oligopeptide libraries by IRORI method and atomic force microscopy by Schmuck group. Proposal addresses CSF goals: a) support the collaboration with well-established international leaders, b) foster training of young researchers by work on the INTERNATIONAL research; c) expected results with commercializing potential (novel biochemical probes and/or drugs). The latter feature (c) will be studied within FP7-REGPOT “Innomol” Project at Ruđer Bošković Institute.]]></summary_en></project><project>
<id>2549</id><title_hr><![CDATA[Organske molekule u kondenziranoj fazi: međudjelovanja i modeliranje]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4668</user_id><user_firstLast_name>Hrvoj Vančik</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-1051</code><acronim><![CDATA[ORGMOL]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>19061</team_members_id><team_members_names><![CDATA[ Doktorand: Petar Bibulić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[reaction mechanisms, solvent effects, solid-state reactions, molecular self-assembly, nitroso compounds, ferrocenes]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[This research will consist of two parallel research pathways. The first will include study of mechanisms of organic reactions in the solid state, and the second will mainly deal with the theoretical study of mechanisms in the solution.Mechanisms of the solid-state processes cannot be interpreted using the established concepts of reaction mechanisms because the phase change plays the crucial role in determining reaction kinetics and the structure of the products. Until now, papers published in this field represent mostly kinetics of phase transformations and descriptions of kinetic data by various mathematical models. As a result, the relationship between such a macroscopic approach and structural changes on the molecular level is still poorly understood. Knowledge about the principles of solid-state reactions is of broad interest, and especially useful to chemists who use solvent-free synthetic methods. In this research, we propose investigations of solid-state reactions based on our recent discoveries and explanations of mechanisms of dimerizations and polymerization of nitroso compounds. Using this established approach and corresponding molecular models, we plan to develop a mechanistic concept of the solid-state reactions, and use it to design novel supramolecular structures.As a starting point of our investigations of organic reaction mechanisms in the solution, we will finish development of our new cluster-continuum solvation model. It will provide us with the most important solute-solvent molecules clusters, allowing the realistic estimates of standard Gibbs energies of involved species and thus prediction of kinetic and thermodynamic data for the examined reactions. The approach will be tested on several model problems, and then used for the analysis of several representative organic mechanisms, including the ones occurring in solids.]]></summary_en></project><project>
<id>2552</id><title_hr><![CDATA[Aerodinamika i aeroelastičnost mostova s ugrađenim cestovnim vjetrobranima]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4960</user_id><user_firstLast_name>Hrvoje Kozmar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-5445</code><acronim><![CDATA[]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, </scie_field_hr><scie_field_en>Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>17884</team_members_id><team_members_names><![CDATA[ Doktorand: Andrija Buljac ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>2553</id><title_hr><![CDATA[Gravitacija i narušenje pariteta]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3313</user_id><user_firstLast_name>Maro Cvitan</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-2072</code><acronim><![CDATA[GRAPARION]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>17858</team_members_id><team_members_names><![CDATA[ Doktorand: Tamara Štemberga ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[gravity, black holes, parity violation, quantum anomalies, holography, string theory, conformal symmetry, entanglement entropy]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The effect of parity or charge-parity (CP) violation in gravitational theories has not been extensively studied so far in the literature. Nevertheless this phenomenon might be very important and help explaining the baryon asymmetry of the Universe: our Universe consists of matter, with the negligible amount of antimatter. Despite many attempts a satisfactory explanation for this asymmetry is not yet at hand, although it is generally accepted that the processes responsible for it must violate CP. The qualifying aim of this project is to explore the idea that CP violation may be traced back to gravity. However we believe it is more effective to cope with this problem in the framework of a more general research on parity violating effects in gravity, which we will study by means of modern methods of exploring the gravitational interaction: holography, Kerr black hole horizon-conformal field theory (Kerr-CFT) correspondence, trace anomalies, entanglement entropy, fluid-gravity correspondence. The focus will be in particular on the natural candidates for parity violating gravity processes - the Chern-Simons terms, both pure gravitational and mixed gauge-gravitational ones - using extra-dimension models inspired by the string theory. The expected outcome is a significant increase in understanding the consequences of parity violating gravitational interactions, not only in relation with possible CP violations, but also for other effects, e.g. for corrections to black hole entropy.]]></summary_en></project><project>
<id>2554</id><title_hr><![CDATA[Computational Studies of the Biogenic Amines of the Brain for Targeting Neurological Diseases]]></title_hr><title_en><![CDATA[]]></title_en><user_id>227</user_id><user_firstLast_name>Robert Vianello</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-8651</code><acronim><![CDATA[]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>3091</team_members_id><team_members_names><![CDATA[ Doktorand: Aleksandra  Maršavelski ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>2555</id><title_hr><![CDATA[Numeričko modeliranje složenih elektromagnetskih pojava u transformatorima]]></title_hr><title_en><![CDATA[]]></title_en><user_id>319</user_id><user_firstLast_name>Bojan Trkulja</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-8561</code><acronim><![CDATA[NM_TRAF]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>17803</team_members_id><team_members_names><![CDATA[ Doktorand: Ana Drandić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[numerical methods, transformers, insulation systems, lossess, high frequency modelling]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Transformers are crucial devices in efficient and reliable transmission and distribution of electricity. Croatian transformer manufacturers are among a top few in the world, and their annual production is worth about €300 million, what is about 2% of the world production. It is possible to keep this position on the world market only if there is a close collaboration between the academic community and transformer manufacturers. Notable progress in technology of transformers is based on utilization of new materials and application of advanced design methodologies, which incorporate sophisticated numerical methods for modelling of processes in transformers. This project is focused on research and development of advanced numerical techniques for solving various electromagnetic phenomena in transformers and their application in design. Crucial subjects in transformer design are: insulation system, electromagnetic losses and windings. Consequently, researches within this project are organized in three subprojects:1.	New methods for design of insulating systems. The aim of this subproject is to develop new comprehensive numerical method for computation of electric fields within the insulating system.2.	Computation of electromagnetic losses with the aim to develop a new method of estimation of stray losses level of power transformer, as well as the methodology of simultaneous modelling of electromagnetic field, thermal field and fluid dynamics field in transformers.3.	High frequency modelling of windings. The objective of this subproject is to develop fast and accurate procedures for the determination of capacitances, inductances and resistances in high-frequency range. These elements will be used for creating an equivalent lumped-element circuit for determination of voltage stresses along a winding.The overall goal is to reduce dimensions of transformers and to increase their reliability by application of new methods and procedures. ]]></summary_en></project><project>
<id>2556</id><title_hr><![CDATA[Formacija i destrukcija domena u vodenim otopinama]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5374</user_id><user_firstLast_name>Larisa Zoranić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-9740</code><acronim><![CDATA[MS-FORMDES]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Science]]></institution_en><team_members_id>5569</team_members_id><team_members_names><![CDATA[ Doktorand: Martina Požar ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[associated liquids, micro-heterogeneity, molecular dynamics, integral equation theory, antimicrobial peptides]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The physics of associated liquids, amphiphilic solutions and lipids in water is determined by competing hydrophobic and hydrophilic interactions between various molecular groups. By exploring assemblies ranging from molecular to cellular sizes we are aiming at  building a unified view of the principal mechanisms responsible for domain formation and destruction. This new approach hasn&#39;t been explored as such in similar research projects. In the project&#39;s first year, by molecular dynamic simulations, we will quantify micro-heterogeneity in liquids as a structural order that exists on the local scale and doesn&#39;t propagate on the global scale. As a continuation of the first-year results, we will study how the structure of the above mentioned liquids changes when dissolving molecules that promote or destroy domains defined by the local ordering. The used methods will be simulations and integral equation theory. In parallel with the molecular scale studies, the cellular membranes will be probed by means of experimental measurements and simulations. The aim will be to describe the mechanism of destruction of lipid bilayers induced by antimicrobial peptides. Principal investigator Larisa Zoranić has competencies to establish a new research group with an interdisciplinary subject and members of diverse fields because of her scientific background in physics, biology and biophysics. She has experience working in both international and Croatian groups, thus obtaining the required managing skills. The group&#39;s acquired knowledge and expertize will ensure a good quality start towards more demanding issues that stem from the project. The aims and methods of this research are competitive internationally in the area of molecular physics and biophysics. This kind of innovative project, built around an interdisciplinary group and having strong connections with the diploma and doctorate studies, will strengthen the Croatian scientific network.]]></summary_en></project><project>
<id>2557</id><title_hr><![CDATA[Prospektivno biopsihosocijalno istraživanje utjecaja seksualno eksplicitnih materijala na socijalizaciju i zdravlje mladih]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5817</user_id><user_firstLast_name>Aleksandar Štulhofer</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-5015</code><acronim><![CDATA[PROBIOPS SEM STUDY]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Sociologija, </scie_field_hr><scie_field_en>Sociology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>17799</team_members_id><team_members_names><![CDATA[ Doktorand: Goran Koletić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Prospective study, panel, young people, reproductive and sexual health, emotional intimacy, committed relationships, sexually explicit material]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Digital technology has enabled an unprecedented availability and unrestricted use of sexually explicit material (SEM). As the first experiences with SEM almost invariably precede first sexual experiences, concerns have been raised about its potential impact on young people’s sexual socialization, subsequent reproductive and sexual health outcomes, as well as motivation and capacity for building and maintaining relationship intimacy. The field of socio-behavioural research on SEM has been marred by inability to distinguish between associations and causal links. The only available European panel study followed Dutch youth for only 12 months. To enable a more robust assessment of the links between SEM use and sexual socialization, health, and intimacy we propose to set up a 3-year panel sample with over 1,000 high-school students. The panel would be used to carry out biological testing on males (testosterone levels from saliva) and repeated online surveying in which the genre and the frequency of SEM use would be analyzed as predictors of subsequent sexual activity (particularly, sexual risk taking), the dynamics of attitudes toward women and committed relationships. We propose to test a conceptual model in which possible SEM influences on the outcomes are influenced by T levels, personality traits, family environment, characteristics of ego-centered social network, type of SEM used, and sexual experiences. Our biopsychosocial model aims to assess the contribution of SEM use to the process of young people’s sexual socialization, while controlling for the effects of biological makeup, intrapersonal characteristics, and interpersonal and group (family, peer group, partners) social influences.The proposed project is innovative in design and analytical conceptualization. The expected outcomes should be relevant not only in scientific terms but also in the context of public policy, particularly in the area of educational and public health interventions.]]></summary_en></project><project>
<id>2558</id><title_hr><![CDATA[Otkrivanje novih genetskih lokusa uključenih u regulaciju funkcije štitne i doštitne žlijezde]]></title_hr><title_en><![CDATA[]]></title_en><user_id>118</user_id><user_firstLast_name>Tatijana Zemunik</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-8198</code><acronim><![CDATA[THYPARATHYFUNCTION]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Split School of Medicine]]></institution_en><team_members_id>17479</team_members_id><team_members_names><![CDATA[ Doktorand: Antonela Boljat ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[thyroid function, parathyroid function, genetic variants, polymorphisms, genome-wide study, gene-environmental interaction, complex phenotypes]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Thyroid diseases affect up to 10% of the general population creating an important public health problem. Parathyroid diseases are less frequent but not insignificant. Thyroid hormones act on every tissue regulating cellular development, differentiation and metabolism. Parathyroid hormones control the amount of calcium in the blood. The expression of thyroid and parathyroid hormones/antibodies is under polygenic control and influenced by environmental factors. The aim of this study is to identify genetic loci that are associated with levels of thyroid/parathyroid hormones and antibodies that will advance our understanding of the genetic basis of their function and thus provide additional knowledge relevant to clinical outcomes.  We will perform genome-wide association analysis of thyroid and parathyroid hormones/antibodies on 1,000 individuals from Split region (participants from the 10,001 Dalmatians project). The thyroid and parathyroid hormones/antibodies that are planned to be analysed are: free triiodothyronine, free thyroxine, thyroid-stimulating hormone, thyroglobulin, thyroid microsomal antibody titer, thyroglobulin antibody titer and parathiroid hormone. In addition, detailed anamnestic data and phenotype measurements already taken from study participants will be used in realization of second and third project objectives: investigation of relevant gene-environment interactions and determination of phenotype-phenotype correlation. We plan to follow-up interesting findings in additional 2,000 individuals and in datasets sought through international collaboration.Outcomes of such comprehensive approach will be generation of a new knowledge of genetic background, gene-environment interaction and phenotype-phenotype correlation associated with thyroid and parathyroid function that will lead to better understanding of biological pathways and clinically relevant disorders related to their function. The obtained results will promote excellence of Croatian research.]]></summary_en></project><project>
<id>2559</id><title_hr><![CDATA[Tvar i međudjelovanja na ubrzivačima  i u svemiru]]></title_hr><title_en><![CDATA[]]></title_en><user_id>335</user_id><user_firstLast_name>Krešimir Kumerički</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-6473</code><acronim><![CDATA[MIAU]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>17794</team_members_id><team_members_names><![CDATA[ Doktorand: Petar Čuljak ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[quantum chromodynamics, hadrons, quarks and gluons, quark matter, leptons, neutrino mass, new particles at LHC, dark matter]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[     Hadrons, such as proton or pion, are particles composed ofquarks and gluons which interact through fundamental strongforce. Objective of MIAU project is to contribute to ourunderstanding of this strong force as described by thetheory of quantum chromodynamics (QCD). Additionally, we aimto study physical processes happening at hadronaccelerators, including electroweak production ofas-yet-unseen particles at the large hadron collider (LHC).Thereby, we will investigate models of new physics in whichsuch new particles are introduced in attempts to explainneutrino masses and abundance of dark matter in theuniverse.     To achieve these objectives we will study specific hadronicprocesses, both in the high-energy regime where strong forceis weak enough for perturbative approach, as well as inregimes where non-perturbative features of QCD, such asconfinement and chiral symmetry breaking come to the fore.Our focus will be on processes measured by the range ofexperimental collaborations which will facilitate closecontact with reality and immediate testing of our resultsand ideas.     As outcome, we expect to be able to significantly improvethe knowledge of the quark-gluon structure of the proton, asencoded by the so-called generalized parton distributions,to improve the description of various meson properties invacuum and at finite densities and temperatures, toelucidate QCD phase diagram in model frameworks, and to setbounds to the parameter space of several models of newphysics.]]></summary_en></project><project>
<id>2560</id><title_hr><![CDATA[FP7 projekt EMBRACE , br.: 282672 ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5979</user_id><user_firstLast_name>Darko Koracin</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-4724</code><acronim><![CDATA[]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Geofizika, </scie_field_hr><scie_field_en>Geophysics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu]]></institution_hr><institution_en><![CDATA[University of Split]]></institution_en><team_members_id>17848</team_members_id><team_members_names><![CDATA[ Doktorand: Slavko Radilović ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>2563</id><title_hr><![CDATA[Dijagnostika autizma s robotskim evaluatorom]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5054</user_id><user_firstLast_name>Zdenko Kovačić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-9417</code><acronim><![CDATA[ADORE]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>5058</team_members_id><team_members_names><![CDATA[ Doktorand: Frano Petric ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[social robotics, humanoid robots, autism, small children, diagnostics, rehabilitation]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Autism spectrum disorder (ASD) is a developmental disorder characterized by impairment in social interaction, verbal and nonverbal communication and by repetitive behaviors and interests. The diagnosis, which is usually given during the preschool period, depends on the education and experience of human evaluators, which can be susceptible to personal bias. The ongoing collaboration between the researchers from the Faculty of Electrical Engineering and Computing (FER) and Faculty of Education and Rehabilitation Sciences (ERF) initiated the use of humanoid robots in the process of ASD diagnostic procedures in preschool children. The goal of the project is the development of a robot-based diagnostic protocol and testing of its verification in clinical settings. The robots will be used as ASD co-evaluators to help a human evaluator to assess the child behavior objectively. To the best of our knowledge, such a robot-based ASD diagnostics system will be the first of its kind. Technically, this means developing specific robot skills and behaviors to be deployed within the standard clinical diagnostic procedure of ASD. The robots will have two functions: observation and quantitative measurement of child’s social responses; and performance of standardized social presses designed to provoke child response. This involves actions such as analyses of the audio signal and differentiation of vocalizations and speech, detection of eye-gaze direction, performance of different actions and gestures and utilization of human-robot and robot-robot interaction to attract child attention. Our interdisciplinary approach includes ERF&#39;s development of diagnostic protocol and its testing on children with and without ASD and FER&#39;s realization of needed robot behaviors using methods and algorithms from social signal processing, computer vision, machine learning and cognitive reasoning. This involves work on cooperation, cognition and human-robot interaction, focusing on multimodal communication.]]></summary_en></project><project>
<id>2564</id><title_hr><![CDATA[Molekularni mehanizmi imunološkog djelovanja PVR(CD155) u virusnoj i tumorskoj patogenezi]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4941</user_id><user_firstLast_name>Tihana Lenac Roviš</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-9006</code><acronim><![CDATA[PVRreg]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Medicine]]></institution_en><team_members_id>5204</team_members_id><team_members_names><![CDATA[ Doktorand: Paola Kučan ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[poliovirus receptor, PVR, CD155, cytomegalovirus, CMV, immunoevasion, tumor]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The project is focused on the role of PVR (poliovirus receptor) which serves as a ligand for both inhibitory (TIGIT) and activating (DNAM-1 and Tactile) receptors. The evidence has been accumulated indicating the role of PVR and its receptors in immune surveillance including the control of viral infections, tumors, as well as in pathogenesis of autoimmune diseases. Of note is that PVR is constitutively expressed on the majority of somatic cells, while its receptors are expressed on the majority of lymphocyte population. In many respects the interaction of PVR with its paired set of inhibitory and activating receptors resemble the interaction of paired co-stimulatory immune cell receptors and their cellular ligands (B7/CD28/CTLA-4). These co-stimulatory molecules have been the subject of intensive studies that resulted in immunoregulatory pharmaceutical agents for use in humans. The studies proposed here are based on the finding that human cytomegalovirus (HCMV) affects the surface expression of PVR (Nat Immunol. 2005) and on our preliminary results indicating that mouse cytomegalovirus (MCMV) also downregulates mouse PVR. Thus, we first focused on the identification of MCMV gene(s) (proteins) involved in the PVR regulation, but also on the consequence of this viral regulation on antiviral immune response in vivo. To that aim we will generate MCMV mutants lacking viral regulators and test their in vivo susceptibility to components of innate and acquired immune response. We expect that the results obtained will further broaden the knowledge of PVR regulation and its significance in immune control, which will eventually help to translate this knowledge to developing new immunotherapeutic tools. Namely, one aim of this project is to engineer antibody specific for human PVR in order to be used as a tool in targeted tumor therapy. This idea is based on the fact that many tumors over-express PVR, which could be used in antibody mediated uptake of anti-tumor compounds. ]]></summary_en></project><project>
<id>2565</id><title_hr><![CDATA[Cjelogenomska analiza povezanosti Hashimotovog tiroiditisa]]></title_hr><title_en><![CDATA[]]></title_en><user_id>63</user_id><user_firstLast_name>Vesna Boraska</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-6867</code><acronim><![CDATA[HashimotoGWAS]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Split School of Medicine]]></institution_en><team_members_id>17744</team_members_id><team_members_names><![CDATA[ Doktorand: Luka Brčić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Hashimoto thyroiditis, thyroid gland, genome-wide association analysis (GWAS), statistical genetics, single nucleotide polymorphism (SNP), biobank]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Autoimmune thyroid diseases (AITD) are very common and affect 2-5% of the general population. The most frequent form of AITD is Hashimoto thyroiditis (HT) that is characterised by progressive destruction of thyroid tissue. Many studies tried to unravel genetic contribution to HT development in the past few decades but with low success. The breakthrough of the genome-wide association studies (GWAS) tremendously increased the rate of detecting novel associations. However, HT has been unrepresented in the GWAS mostly because of the lack of large cohorts of HT patients and the performance of such study is a matter of urgency. We plan to recruit 500 HT patients and to create a DNA/serum/plasma biobank of deeply phenotyped HT patients that will serve as a powerful resource for current and future investigations. The aim of this study is to identify genetic variants underlying HT by performing the first GWAS focusing on HT exclusively. We will use newly recruited HT patients and 500 existing controls (from the “10,000 Dalmatians” study) in case-control GWAS and validate observed associations in an independent replication cohort. To further help in elucidating genetic contribution to HT we will perform pathway analysis and gene-interaction analysis using variety of environmental factors and medical records that will be collected from HT patients. We will also perform deep phenotype characterisation of HT patients that may provide additional clues about HT aetiology. This is timely planned study that aims to generate new knowledge that will advance our understanding of the genetic basis and underlying biological mechanisms of HT. This knowledge will be crucial in guiding the development of new prevention, diagnostic and therapeutic methods. Other benefits of this project include promotion of collaboration, transfer of knowledge, building of infrastructure and it will help in establishment of independent research carrier of principal investigator.]]></summary_en></project><project>
<id>2566</id><title_hr><![CDATA[Ekološki prihvatljiva zaštita metalnih konstrukcija izloženih agresivnom djelovanju mora]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5203</user_id><user_firstLast_name>Helena Otmačić Ćurković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-9683</code><acronim><![CDATA[]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Kemijsko inženjerstvo, </scie_field_hr><scie_field_en>Chemical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet kemijskog inženjerstva i tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Chemical Engineering and Technology]]></institution_en><team_members_id>17745</team_members_id><team_members_names><![CDATA[ Doktorand: Ekatarina Kristan ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>2567</id><title_hr><![CDATA[Klima jadranske regije u njenom globalnom kontekstu]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3375</user_id><user_firstLast_name>Mirko Orlić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-3666</code><acronim><![CDATA[CARE]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Geofizika, </scie_field_hr><scie_field_en>Geophysics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>17753</team_members_id><team_members_names><![CDATA[ Doktorand: Maja Bubalo ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Adriatic, climate change, extremes, climate models, downscaling, spatial interpolation, sea-level trend, coastal flooding, sea-level projections]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Temporal and spatial statistical analysis of climatological variables will be performed, with the emphasis on the multidecadal changes in temperature and precipitation indices of extremes in the Adriatic region. Particular attention will be paid to the analysis of drought, floods and heat waves. Possible change in climate suitability for tourism will be investigated. The obtained gridded fields will become a reference data for the validation of climate models and an input into the flash-flood warning systems. Current and future climate of the Mediterranean area will be examined by analyzing the results of global-model simulations and by using the statistical and dynamical downscaling approach. Simulations by RegCM4.2 regional climate model will be performed at the horizontal resolution of 12.5 km. Also planned is to utilize results from experiments based on coupled atmosphere-ocean models from the currently running Med-CORDEX project with a purpose of analyzing the contribution of oceanic component in the simulations over the Adriatic Sea and the surrounding land area. Trends and interdecadal variability of sea level in the Mediterranean sub-basins will be identified and contributions of the governing processes will be assessed. Coastal flooding in the Northern Adriatic and time evolution in occurrence of extreme sea levels in the context of mean-sea-level rise will be considered. Finally, older variants of semi-empirical method of projecting global sea level will be compared with the more general method recently developed. It is expected that the project thus considered will meet the three important criteria (relevance, reliability, feasibility), by addressing one of the few priorities put forward by the European Union in its growth strategy Europe 2020, by relying on the state-of-the-art methods of data analysis and modeling, and by involving a majority of researchers engaged in the study of climate-related physical processes in Croatia.]]></summary_en></project><project>
<id>2568</id><title_hr><![CDATA[Uokvireno ziđe - kompozitni nosivi sustav kod armirano-betonskih zgrada]]></title_hr><title_en><![CDATA[]]></title_en><user_id>131</user_id><user_firstLast_name>Vladimir Sigmund</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-8930</code><acronim><![CDATA[FRAmed-MAsonry]]></acronim><duration></duration><status>Prekinut</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Građevinarstvo, </scie_field_hr><scie_field_en>Civil engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Građevinski i arhitektonski fakultet Osijek]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Civil Engineering and Architecture Osijek]]></institution_en><team_members_id>17741</team_members_id><team_members_names><![CDATA[ Doktorand: Ervin Kožoman ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[r/c frames, masonry infill, behavior, safety, modelling, standardization, framed-masonry]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[In r-c frames infilled with masonry (framed-masonry) the infill walls stiffen the frame and reduce the first-mode period leading to a reduction in drift response to strong ground motion. At the same time, the addition of the masonry wall to the frame tends to increase the base-shear response and reduce the drift capacity of the structure. The increase of lateral force and reduction of drift capacity leads to serious vulnerabilities unless proper proportioning is exercised. For frames with competent walls, the challenge for safe and economical design is to be able to take advantage of the stiffening but to make certain that the increase in lateral forces and reduction in drift capacity do not handicap performance. Available evidence has pointed out that shear strength of the confining column is the &#39;&#39;Achiless&#39;s heel&#39;&#39; of the system. Solution of the problem requires understanding the behavior of masonry and concrete subjected to dynamic and random loading reversals, a challenge that demands testing under reasonably realistic conditions for confident analysis of the problem and its generalization.This is a proposal to investigate the safety and behavior of buildings with masonry-infilled r-c frames through near full-scale dynamic earthquake-simulation tests accompanied by supporting pseudo-dynamic tests of structural assemblies and components and by calibrated analytical solutions. The overall goal is to develop pragmatic methods, by cooperative efforts of team members and co-working international body, for design, safety evaluation and standardization. Because framed-masonry serve both architectural and structural demands efficiently, people in seismic regions live and will continue to live in buildings of this type. An organized solution of the safety of such construction is essential. This proposal intends to put the &#39;&#39;framed-masonry&#39;&#39; composite up as a full-fledged building type, it is &#39;&#39;transformative&#39;&#39; and will change design practice.]]></summary_en></project><project>
<id>2569</id><title_hr><![CDATA[Povezanost fleksibilnosti, aktivnosti i strukture u porodici dipeptidil-peptidaza III]]></title_hr><title_en><![CDATA[]]></title_en><user_id>2974</user_id><user_firstLast_name>Sanja Tomić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-6802</code><acronim><![CDATA[FlAcS]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>17832</team_members_id><team_members_names><![CDATA[ Doktorand: Marko Tomin ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[dipeptidyl peptidase III, metallopeptidase, catalytic activity, protein flexibility, MD simulations, QM/MM, H/D exchange, protein interactions]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Within the project frame we intend to investigate diversity in evolutionary conserved metallopeptidase family M49 (DPP III family) through characterization of catalytic, structural and dynamical properties of its members. The project would encompass five dipeptidyl peptidases III (DPP III): human, yeast, two bacterial orthologs, from thermophile Caldithrix abyssi and oral pathogen Porphyromonas gingivalis, and a DPP III from plant Physcomitrella patens. The DPP III cleaves dipeptides from the N-terminus of many oligopeptides and contributes to the intracellular protein metabolism as well as to endogenous defense against oxidative stress. Human DPP III (h.DPP III) is also related to pathological processes of cataractogenesis, tumor growth and influenza virus infection. The project research should elucidate whether the large flexibility determined for h.DPP III is conserved within DPP IIIs, and how it correlates with the protein function. It would reveal submolecular details important for substrate stabilization and, in the case of h.DPP III, the enzymatic mechanism. Elucidation of the key interactions between h.DPP III and Keap1 protein (Nrf2-Keap1 signalling pathway is major regulator of cytoprotective responses to oxidative and electrophilic stress), and possible correlation of DPP III flexibility with the complex stability, should aid in clarification of its cellular roles. Plant DPP III, differently from DPP IIIs in other organisms possesses a NUDIX box. The project should elucidate its potential dual activity (peptidase and NUDIX). Study of DPP III from thermophile should improve our knowledge on thermophile proteins, potentially useful in biotechnology. In order to fulfill the outlined goals a finely tuned multidisciplinary approach would be used in which molecular biology, biochemistry and mass spectrometry methods would be complemented with bioinformatics, multiscale molecular modeling (coarse grained/all atom MD, QM/MM) and macromolecular crystallography.]]></summary_en></project><project>
<id>2570</id><title_hr><![CDATA[Razvoj fotokatalitičkih polimernih nanokompozita za obradu otpadnih voda]]></title_hr><title_en><![CDATA[]]></title_en><user_id>913</user_id><user_firstLast_name>Zlata Hrnjak-Murgić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-1233</code><acronim><![CDATA[DePoNPhoto]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Kemijsko inženjerstvo, </scie_field_hr><scie_field_en>Chemical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet kemijskog inženjerstva i tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Chemical Engineering and Technology]]></institution_en><team_members_id>17771</team_members_id><team_members_names><![CDATA[ Doktorand: Vanja Gilja ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[conducting polymers,  metal oxide nanoparticles, polymer nanocomposites, structure-properties relations, wastewater treatment]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Environmental problems associated with water pollution are an important issue correlated negatively with the health and ecosystem. The main goal of this proposal is to develop novel polymer nanocomposites of extending photoactivity toward visible region under UV/VIS light irradiation and to introduce an innovative technology for water purification. The conducting polymers (CPs) are known as good hole conducting materials1 and are combined with semiconductor nanoparticles to produce a synergistic effect and complementary properties. Due to that Polyaniline (PANI), polypyrrole (PPy) and poly(3,4-ethylene-dioxythiophene) (PEDOT) conducting polymers will be studied with metal oxides (TiO2, ZnO) nanoparticles to develop polymer nanocomposite photocatalysts (CPNPs) with enhanced photocatalytic properties. The optimal structure-properties relationships are crucial for efficient degradation of organic contaminants in water to convert them into harmless chemicals. Novel CPNPs will be applied in photocatalytic degradation of organic azo dyes (reactive red 45 and methyl orange) chosen as targeted wastewater pollutants. The utilization of waste material, fly ash, as a catalyst support will be explored to provide the additional environmental benefit. The proposed integral approach that will be used in the evaluation of the process efficiency will scrutinize any negative implications of CPNPs application. The project will contribute to the development and modernization of science and technology in Croatia, advancing toward the knowledge-based society within the European research area.Project includes a multidisciplinary effort, ranging from polymer science and technology, chemistry and environmental chemistry to electrochemical engineering, in order to meet challenging project tasks and propose an efficient photocatalytic polymer nanocomposite for sustainable water treatment technology. 1. M.R. Karim, C.J. Lee, Y.T. Park, M.S. Lee, J. Polym. Chem. 14 (2006) 5283–5290.]]></summary_en></project><project>
<id>2571</id><title_hr><![CDATA[eWALL]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5854</user_id><user_firstLast_name>Dina Šimunić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-6634</code><acronim><![CDATA[]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>19130</team_members_id><team_members_names><![CDATA[ Doktorand: Antonija Marinčić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>2572</id><title_hr><![CDATA[Multi-level actions for enhanced Heating & Cooling plans (STRATEGO)]]></title_hr><title_en><![CDATA[]]></title_en><user_id>2536</user_id><user_firstLast_name>Daniel Rolph Schneider</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-6302</code><acronim><![CDATA[]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, </scie_field_hr><scie_field_en>Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>17796</team_members_id><team_members_names><![CDATA[ Doktorand: Tihomir Tomić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>2573</id><title_hr><![CDATA[Tekstilne antene za pametno okruženje]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6555</user_id><user_firstLast_name>Davor Bonefačić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-6996</code><acronim><![CDATA[TexASE]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>17757</team_members_id><team_members_names><![CDATA[ Doktorand: Andrej Galoić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[antenna, textile antenna, wearable antenna, on-body communications, body-centric communications]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The smart environment consists of wired and wireless network of communication devices and sensors which communicate between themselves and with humans, and enable safer, more pleasant and energy efficient environment adaptable to the change of conditions and tasks. Any wireless device needs an antenna as the interface between the electronic circuits and the free space. Wireless communication modules, sensors and RFID devices are integrated in common objects like clothes, home appliances, toys, consumables, etc. The used antennas must be small and unobtrusive, yet energy efficient. The aim of this project is to investigate new materials and techniques for antenna fabrication including conductive textiles and threads. A textile antenna integrated into clothes must be lightweight, flexible, and comfortable to wear, but still must keep good radiation properties. Textile antennas are very interesting for military personnel on the field as well as for rescue teams. Another important application is healthcare, where wireless sensors in real time monitor the patients&#39; health status and transmit data to the medical personnel. The broadest field of application of wearable antennas is in the entertainment and consumer electronics and mobile communications. Energy harvesting, and with it the associated antennas, can be used in all these fields to increase energy efficiency and enable operation of mobile devices. The aim of this project is to propose new and adapt existing antenna designs for integration into clothing and for new manufacturing techniques like embroidering or weaving. Another aspect to be considered in connection with wearable antennas is their operation in the proximity of human body which is a lossy dielectric. The second aim of this project is to study both theoretically and experimentally the propagation channel on the surface of the human body and off-body communications. The results will allow designing reliable on-body and off-body communication systems. ]]></summary_en></project><project>
<id>2575</id><title_hr><![CDATA[Fizika Standardnog modela i njena proširenja]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4709</user_id><user_firstLast_name>Fabrizio Nesti</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-3949</code><acronim><![CDATA[PhySMaB]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>17814</team_members_id><team_members_names><![CDATA[ Doktorand: Goran Popara ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[theoretical particle physics,  Standard Model, perturbative calculations, physics beyond Standard Model, neutrinos]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[In high energy particle physics it is widely believed that the energy frontier experiments at LHC and the planned linear colliders, ILC and/or CLIC, together with ongoing and new experiments in neutrino and flavour physics will unravel fundamental problems in particle and astroparticle physics. A prerequisite for this progress is the complete understanding of the Standard model (SM) predictions. One of the triumphs of SM physics has been the extent to which QCD successfully describes strong interaction processes observed at colliders. More accurate QCD calculations are nowadays essential in understanding the enormous amount of available high-precision data, particularly since new physics effects are obscured by standard QCD processes. Our focus in that area will be to improve the description of hard exclusive processes by including higher-order contributions and by further developing the corresponding methods for automatic QCD calculations. Furthermore, we plan to do precision studies of top-quark production and decay observables which provide a unique view to the mechanism of electroweak symmetry breaking, important for understanding of particle mass generation. In the top-quark decay the information about its spin polarization imprinted by the production process is preserved, and can be calculated and measured in angular distributions of decay products providing other way to search for deviations from the SM expectations. Regarding new physics, the fact that neutrinos have a mass already requires an extension of the SM and calls for an understanding of the origin of neutrino masses. The seesaw mechanism, included in a theory as the one where left-right symmetry (parity) is restored at accessible LHC energies, stands out as a prominent theoretical candidate, and this theory links the origin of neutrino masses to new interactions at high energies and to the restoration of parity. A phenomenological investigation of these predictions is thus compelling and timely.]]></summary_en></project><project>
<id>2576</id><title_hr><![CDATA[„Metal-Hydride Organic Frameworks (HOF)-new solids for gas adsorption and separation”- SCOPES projekt]]></title_hr><title_en><![CDATA[]]></title_en><user_id>11146</user_id><user_firstLast_name>Jasminka Popovic</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-9951</code><acronim><![CDATA[]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>17733</team_members_id><team_members_names><![CDATA[ Doktorand: Sanja Brkić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>2577</id><title_hr><![CDATA[Detekcija objekata više razreda za pametna vozila i sigurnije ceste]]></title_hr><title_en><![CDATA[]]></title_en><user_id>361</user_id><user_firstLast_name>Siniša Šegvić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-4744</code><acronim><![CDATA[MULTICLOD]]></acronim><duration></duration><status>Prekinut</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>6565</team_members_id><team_members_names><![CDATA[ Doktorand: Ivan Krešo ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Computer vision, structure from motion, object detection, image categorization, multi-body structure from motion]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Throughout the last decades we witness persistent improvement in understanding ways to make machines see. Consequently, opportunities for computer vision applications are becoming more and more abundant. Understanding dynamic traffic scenes is especially interesting due to exciting applications in the fields of smart vehicles (driver assistance, autonomous cars) and intelligent transportation systems (road safety inspection, adaptive traffic control). Nevertheless, many of these applications are out of reach since the computers are still unable to match human perception. We believe that this gap would be reduced by improving our understanding of scalable detection of multiple object classes in dynamic scenes.The task of object detection is to localize objects of interest in input images. We address detection in the most general case where the objects of interest exhibit large appearance variation. In this case the problem is often referred to as multi-class object detection. Our proposal focuses on dynamic traffic scenes acquired by a calibrated stereo rig from the driver&#39;s perspective. We propose to develop detection approaches which would combine estimated camera motion and scene structure with learned appearance features, and to experimentally compare them with the state of the art. We shall employ advanced methodologies such as SfM, dense stereo, variational optimization, scene flow, spatio-temporal descriptors, latent SVM and Fisher vectors. These methodologies shall enable us to achieve improvements upon the state of the art in terms of scalability and detection performance. This will open way to exciting applications capable of reducing traffic accidents, improving efficiency and decreasing traffic congestion. Some of these applications shall be demonstrated by experiments on a real autonomous car. The proposed research would also contribute to a future unified theory of computer vision which would encompass detection, reconstruction and categorization.]]></summary_en></project><project>
<id>2580</id><title_hr><![CDATA[GENOMIKA I MOLEKULARNA EPIDEMIOLOGIJA HUMANIH PARAMIKSOVIRUSA U HRVATSKOJ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>936</user_id><user_firstLast_name>DUBRAVKO FORČIĆ</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-3771</code><acronim><![CDATA[ParamyxoCro]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu]]></institution_hr><institution_en><![CDATA[University of Zagreb]]></institution_en><team_members_id>17817</team_members_id><team_members_names><![CDATA[ Doktorand: Anamarija Slović ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Paramyxoviruses, molecular evolution, genomics, virus genotype, molecular epidemiology]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The family Paramyxoviridae harbors a broad spectrum of serious virus pathogens that are of importance to human health and global economics. Paramyxoviruses are RNA viruses with a single-stranded negative sense genome. They have been isolated from a wide variety of species, demonstrating a vast host range and great viral genetic diversity. These ubiquitous pathogens are among the most common causatives of respiratory tract infections and are responsible for a high degree of morbidity and mortality worldwide. The biology of RNA viruses is influenced by their high potential of continuous evolution. Because of the error-prone nature of their RNA-dependent RNA polymerases and large population sizes, RNA viruses show high levels of genetic diversity. Mutations can significantly influence virus biological properties and lead to appearance of new strains. The knowledge of viral evolution depends on the amount of genomic data available for analysis.We propose the research of viral genomics of wild type paramyxoviruses currently circulating in Croatia. It is our goal to increase the number of genetically well characterized paramyxoviral wild-type strains. The proposed work will add to knowledge about paramyxoviral ecology, variability and evolutionary capacities. As molecular epidemiologic monitoring of circulating wild type viruses enables analysis of current relations between existing viral genotypes, it is an invaluable part of virus surveillance and control, facilitating the detection of endemic areas, estimations of vaccine efficacies and predications of possible outbreaks.]]></summary_en></project><project>
<id>2581</id><title_hr><![CDATA[Istraživanje uloge optineurina u neuroprotekciji]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4630</user_id><user_firstLast_name>Ivana Munitić </user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-4658</code><acronim><![CDATA[OptineurinNeuroimm]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Biotehnologija, </scie_field_hr><scie_field_en>Biotechnology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Fakultet biotehnologije i razvoja lijekova]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Biotechnology and Drug Development]]></institution_en><team_members_id>12500</team_members_id><team_members_names><![CDATA[ Doktorand: Andrea Markovinović ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[cell signalling, autophagy, microglia, neurodegeneration, animal models]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Mutations in a widely expressed ubiquitin-binding protein optineurin were recently found in amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease of unresolved pathogenesis. Unlike most of the other mutated proteins known to cause ALS by their toxic prion-like properties, optineurin is largely thought to cause disease by loss-of-function, arguing for its protective role. In vitro studies proposed that it regulates a variety of cellular processes including cell signaling, autophagy and vesicle trafficking, but their link to neurodegeneration is unknown. ALS is not an autonomous disease of selected neurons. Glial cells including microglia, are essential for neuroinflammation, which greatly shapes disease progression. The major aim of this study is to elucidate the exact role(s) whereby optineurin exerts neuroprotection, pinpoint the cell types in which it acts, and determine its putative effect(s) on the interactions between the cell types relevant for neurodegeneration. We aim to dissect these questions in a stepwise fashion by (1) assessing cell-intrinsic functions in neurons, microglia and macrophages, (2) addressing crosstalk in mix-and-match co-cultures and organotypic spinal cord slices, and (3) verifying these findings in mice. To this end, we have generated a novel disease-mimicking genetic mouse model of optineurin insufficiency. Analyzing the function of optineurin in primary cells and mice models is crucial to the success of this study, given that ubiquitin-binding proteins are prone to in vitro artifacts. Incomplete understanding of ALS pathogenesis is directly mirrored in almost complete inability to treat ALS patients: a single approved drug exerts only a small prolongation in survival. Here, we propose to study a unique ALS model, set apart from the currently available models of direct toxicity by its ability to provide insight into basic neuroprotective mechanisms, thus expectedly paving the way for more successful therapies.]]></summary_en></project><project>
<id>2582</id><title_hr><![CDATA[Genetika i fiziologija tolerancije na višestruki stres kod kukuruza]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3305</user_id><user_firstLast_name>Domagoj Šimić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-6159</code><acronim><![CDATA[MUST-MAIZE]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Poljoprivredni institut Osijek]]></institution_hr><institution_en><![CDATA[Agricultural Institute Osijek]]></institution_en><team_members_id>17788</team_members_id><team_members_names><![CDATA[ Doktorand: Vlatko Galić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[drought, diabrotica, plant density, cadmium excess, genomic selection]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Plant responses to different stresses are highly complex and involve changes at the genetic and physiological levels. Maize as a major crop worldwide is essential for industry and is cultivated mostly in rain-fed cropping systems where changes in climate or diminishing water supply take place. Grain yield, the most important trait in maize as a composite trait is influenced by many stress-related traits. The main goal of this project is to elucidate and integrate common genetic and physiological mechanisms underlying the multiple-stress tolerance in maize. The specific aims are to detect genetic and physiological factors responsible for plant response to high plant density, drought, Diabrotica and Fusarium attacks as well as cadmium excess in soil in testcrosses of two maize populations (reference IBM population and a doubled haploid population) and their respective parents. By investigating root and leaf characteristics including chlorophyll fluorescence and other stress parameters as reliable indicators of stress in four-year field and pot experiments conducted in Croatia and Turkey, DNA marker-assisted selection and genomic selection could accelerate maize breeding for yield, abiotic and biotic stress tolerance. A multidisciplinary approach, which ties together breeding, physiology and molecular genetics, can bring a synergistic understanding to the response of maize to multiple stresses.]]></summary_en></project><project>
<id>2583</id><title_hr><![CDATA[Definiranje uloge cirkadijurnih gena kod bihevioralne senzitizacije na psihostimulanse kod Drosophile melanogaster]]></title_hr><title_en><![CDATA[]]></title_en><user_id>69</user_id><user_firstLast_name>Rozi Andretić Waldowski</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-9244</code><acronim><![CDATA[FLYHIGH]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci]]></institution_hr><institution_en><![CDATA[University of Rijeka]]></institution_en><team_members_id>4624</team_members_id><team_members_names><![CDATA[ Doktorand: Ana Filošević ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[addiction, psychostimulants, Drosophila, circadian, genes, screen]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Addiction to drugs is a brain disease characterized by changes in the brain functioning caused by repeated drug taking. Repeated drug taking leads to neuroadaptations which over time affect neural networks and change behavior. One such change induced by drugs and commonly studied in lab animals is behavioral sensitization. Regulation of gene expression is one important mechanism by which drugs change the plasticity of the networks which regulate behavior. A group of transcriptional regulators of the molecular circadian clock have been identified to function as regulators of behavioral sensitization to cocaine in Drosophila. Subsequent studies in rodents proved the universality of those genes in mediating drug responses. The genetic pathways and molecular interactions through which circadian genes regulate drug responses has remained undefined.We hypothesize that new genes which interact with circadian genes in the regulation of behavioral sensitization to psychostimulants can be identified in a genetic screen in Drosophila. This is a goal for which Drosophila is perfectly suited, because genetic screens aimed at defining new genes can be performed relatively easy, fast and cheap. Our first aim is to devise a high-throughput method for measuring behavioral sensitization in flies by modifying the existing method for measuring activity. Second, we will undertake a directed behavioral screen by pre-selecting candidates with reported molecular interaction with circadian genes. In the third aim we will use transgenic flies and other genetic tools to investigate neural mechanisms involved in behavioral sensitization. The proposed research is innovative and relevant for human health. New gene candidates isolated in this screen could easily be translated into mammalian research where they will help in further understanding of neuroplastic changes induced by psychostimulants. Given our expertise and available resources the project has great potential to advance the field.]]></summary_en></project><project>
<id>2584</id><title_hr><![CDATA[Repozitorij metafora hrvatskoga jezika]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3388</user_id><user_firstLast_name>Kristina Štrkalj Despot</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-6207</code><acronim><![CDATA[Meta4Cro]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filologija, </scie_field_hr><scie_field_en>Philology, </scie_field_en><institution_hr><![CDATA[Institut za hrvatski jezik]]></institution_hr><institution_en><![CDATA[Institute of Croatian Language]]></institution_en><team_members_id>4835</team_members_id><team_members_names><![CDATA[ Doktorand: Ivan Pandžić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[conceptual metaphor, image schemas, frames, metonymy, metaphor in natural language processing and artificial intelligence]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The Croatian Metaphor Repository project will involve: theoretical research of conceptual metaphor, metonymy, image schemas and frames in the Croatian language from a synchronic and diachronic perspective; computational linguistic research on metaphor in natural language processing and artificial intelligence involving developing tools for semi-automatic metaphor detection and semi-automatic extraction of linguistic metaphors; psychological experiments to further explain the nature of the links between concept meaning and perception as manifested through primary metaphors. The applied goal of the project is to create a metaphorical language database ? the Croatian Metaphor Repository. The database will be available on the Internet. It will include the following levels: conceptual metaphors, linguistic metaphors, image schemas, cogs and frames. Metaphors will be divided by type (primary, complex and entailed metaphors), by level (general, specific), and by family (Event Structure Metaphors, Mind Metaphors, Morality Metaphors, Scalar Metaphors, Time Metaphors, Emotion Metaphors, Economics Metaphors, Governance Metaphors, Cascade Metaphors, Well-being Metaphors etc.). The theoretical background for the linguistic analysis of conceptual metaphors is the Neural Theory of Language and Thought and the Neural Theory of Metaphor. Formal annotation tools are taken from embodied construction grammar. Both theoretical research and the creation of the repository will significantly advance Croatian cognitive and computational linguistics, artificial intelligence studies and the research of language and learning processes. The database will allow for generalizations and will become a very useful tool for cross-linguistic and cross-cultural research of metaphor and thought leading to further development of the theory and the field and to understanding how people learn, understand, and use language. The project has significant potential for further international development.]]></summary_en></project><project>
<id>2586</id><title_hr><![CDATA[Upravljanje vodom i toplinom i trajnost membranskih gorivnih članaka]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1118</user_id><user_firstLast_name>Frano Barbir</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-4783</code><acronim><![CDATA[PEMFUELCELL]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, </scie_field_hr><scie_field_en>Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Fakultet elektrotehnike, strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Electrical Engineering, Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>17740</team_members_id><team_members_names><![CDATA[ Doktorand: Ivan Pivac ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[PEM fuel cell,  temperature control, humidity of reactant gases, durability stressors, decay mechanisms]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The subject of the proposed research and development are the fuel cells – devices for direct electrochemical conversion of fuel (usually hydrogen) into electricity, with many potential applications, from propulsion of vehicles to mobile and stationary power generation at different scales (from mW to MW). This project will investigate a possibility to design and operate a Polymer Electrolyte Membrane (PEM) fuel cell with ambient air without external humidification using water and heat produced inside the fuel cell. This may be accomplished with adequate temperature distribution along the cathode channel, which would require a specific design of the fuel cell in terms of spatially variable heat transfer rates, and corresponding control of the cooling subsystem. In order to determine whether the proposed concept would result in longer life of fuel cell, some basic understanding of causes of fuel cell degradation is needed, particularly related to water and heat management. Particularly, it is proposed to investigate heat transfer in nano-structured catalyst layer because inadequate heat removal from the electrochemical reaction sites may be one of the causes for fuel cell degradation. Other stressors will be studied as well, and procedures for accelerated durability testing will be established, in order to confirm that the proposed concept of  water and heat management is beneficial to fuel cell durability.The proposed research is expected to improve understanding of water and heat transfer in PEM fuel cell, including the effects that dry conditions and inadequate heat removal from the catalyst sites may have on fuel cell durability. This novel concept of variable temperature along the cathode channel would result in simplification of the fuel cell support system by eliminating the devices needed for external humidification, without affecting fuel cell performance and durability in various applications.]]></summary_en></project><project>
<id>2587</id><title_hr><![CDATA[Sveobuhvatni model istraživanja zabrinutosti za privatnost u online okruženju]]></title_hr><title_en><![CDATA[]]></title_en><user_id>177</user_id><user_firstLast_name>Jelena Budak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-7067</code><acronim><![CDATA[PRICON]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, </scie_field_hr><scie_field_en>Economy, </scie_field_en><institution_hr><![CDATA[Ekonomski institut Zagreb]]></institution_hr><institution_en><![CDATA[Institute of Economics in Zagreb]]></institution_en><team_members_id>17736</team_members_id><team_members_names><![CDATA[ Doktorand: Vedran Recher ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[online privacy concern, antecedents, internet, consumer protection, survey]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The research project will develop a comprehensive integrated model of privacy concern in the online environment and empirically test it in order to provide deeper understanding of various interactions between antecedents, concerns and consequences of online privacy. The research objectives will be achieved initially by identifying and developing (i) a comprehensive list of antecedents such as demographic factors (e.g. gender, education), experience factors (e.g. internet use experience, web expertise) and social-psychological factors (values, attitudes), and (ii) a comprehensive list of consequences of online privacy concern on individual-user level. These inputs will be used to develop an extended integrated model of online privacy concern in order to examine conceptual interrelations. Upon building a model, a customized survey questionnaire will be designed and measurement instruments for variables tested. The field research will consist of surveying 2,000 citizens in Croatia to assess their attitudes and behavior patterns when taking different roles and actions in the online environment. This core part of the research aims to empirically test the conceptualized model by employing adequate analytical tools to the large database collected in the survey. The research will result in the final definition of integrated theoretical framework of online privacy concern that will consolidate various streams of research in this field. The extended model of online privacy concern could be applied in future development in the related domain. The additional project outcomes are policy implications and recommendations for regulatory control, internet users policy and business strategies.]]></summary_en></project><project>
<id>2588</id><title_hr><![CDATA[Dizajn, sinteza i evaluacija novih protuotrova kod trovanja živčanim bojnim otrovima i pesticidima]]></title_hr><title_en><![CDATA[]]></title_en><user_id>872</user_id><user_firstLast_name>Zrinka Kovarik</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-4854</code><acronim><![CDATA[CHOLINESTERASE]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut za medicinska istraživanja i medicinu rada]]></institution_hr><institution_en><![CDATA[Institute for Medical Research and Occupational Health]]></institution_en><team_members_id>17747</team_members_id><team_members_names><![CDATA[ Doktorand: Tamara Zorbaz ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[acetylcholinesterase, butyrylcholinesterase, bioscavengers, prophylaxis, in silico drug-design, oximes, bronchodilatators]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Our main goal is to develop new compounds to serve as more efficient antidotes and improve the treatment of highly toxic organophosphorus (OP) compound poisoning. OP compounds used as pesticides account for over 3,000,000 registered accidental or deliberate cases of poisoning per year worldwide. Furthermore, OPs known as nerve agents (soman, sarin, tabun, VX) present a threat in terrorist attacks and conflicts, as was the case recently in Syria. The main targets of OP compounds are cholinesterases: acetylcholinesterase (AChE), the essential enzyme in neurotransmission, and butyrylcholinesterase (BChE), its back-up enzyme. However, the antidotes currently in use, which act as reactivators of inhibited AChE, were empirically synthesized before the two enzyme’s crystal structures were resolved. Due to structural requirements, their binding affinity and reactivation rate have not been well-balanced. This project utilizes new compounds to gain a better understanding of the mechanistic basis of the limitations of reactivation and find new effective leads for further in vivo study. We will combine several approaches, including: a study of the finely tuned interplay between these two sister enzymes, computational and experimental studies of cholinesterase interactions with a wide range of ligands defining favourable characteristic for potential new antidotes, in silico design of novel compounds that will direct the subsequent synthesis of selected leads, and thorough in vitro and in vivo experimental evaluation guided by strict cost-benefit criteria. Such a comprehensive approach will enable us to test a wide selection of candidates in a more reliable manner and obtain unambiguous data for further enhancements of the antidotal treatment. This will also enable us to explore other possible OP treatments such as highly-effective bioscavengers. Many of the findings that would arise from this project should have an impact that reaches far beyond the level of cholinesterases.]]></summary_en></project><project>
<id>2589</id><title_hr><![CDATA[Karakteristike turbulencije bure (CATURBO), br. 09/151]]></title_hr><title_en><![CDATA[]]></title_en><user_id>11142</user_id><user_firstLast_name>Maja  Telišman Prtenjak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-6713</code><acronim><![CDATA[]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Geofizika, </scie_field_hr><scie_field_en>Geophysics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>17750</team_members_id><team_members_names><![CDATA[ Doktorand: Andreina Belušić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>2590</id><title_hr><![CDATA[Potraga za novim standardnim modelom elementarnih čestica na LHC-u: od preciznih mjerenja elektroslabih procesa do direktnih potraga za novom fizikom]]></title_hr><title_en><![CDATA[]]></title_en><user_id>11164</user_id><user_firstLast_name>Vuko Brigljević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-8266</code><acronim><![CDATA[]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>17843</team_members_id><team_members_names><![CDATA[ Doktorand: Benjamin Mesić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>2591</id><title_hr><![CDATA[Primjena inovativnih tehnologija u proizvodnji biljnih ekstrakata kao sastojaka funkcionalne hrane]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1243</user_id><user_firstLast_name>Verica Dragović-Uzelac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-9368</code><acronim><![CDATA[IT-PE-FF]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Prehrambena tehnologija, </scie_field_hr><scie_field_en>Food technology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Food Technology and Biotechnology]]></institution_en><team_members_id>17829</team_members_id><team_members_names><![CDATA[ Doktorand: Vanja Plazibat ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[medicinal and aromatic plants, innovative technologies, plant extracts, bioactive compounds, bioavailability, antioxidant properties ]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Medicinal and aromatic plants (MAPs) contain numerous bioactive compounds (BACs) (e.g. polyphenols, carotenoids, organosulphur compounds) that can affect the nutritive, chemical, microbiological, and sensory quality of food products. Additionally, they may provide numerous positive effects to the human health (such as risk reduction for: cardiovascular disease, diabetes, obesity, hypertension etc.). Due to large structural diversity among different groups of BACs and their physical/chemical properties it is important to identify/optimize the most effective extraction methods required to isolate and/or separate them from other plant components. Hence, various innovative extraction techniques (e.g. microwave-, ultrasound- and high-pressure- assisted extraction) will be tested for plant extracts production with high BACs content from selected MAPs grown in Croatia. Each applied extraction technique will be optimized with regards to particular MAP, increasing extraction yield, enhancing quality of extract, shortening extraction time, and decreasing solvent consumption. MAPs extracts and/or BACs will be analyzed for antioxidant properties with application of various assays (e.g. total antioxidant, hydrogen peroxide scavenging, and free radical scavenging, metal chelating activities). Antiproliferative effects against tumor cells and possible protective role from lipid oxidation (including antioxidant activity) will be tested in appropriate cell line model system. The MAP extracts (dried/liquid) and BACs (extracted and/or purified separately or in mixtures) will be studied in animal models for bioavailability; absorption; antioxidant activity; as ingredient for functional food products (fortified beverages and snack bars based on Mediterranean fruits), and for possible use in diabetic/hypercholesteremic management. The obtained results may provide novel opportunities for functional product categories that are likely to have positive benefits on human health.]]></summary_en></project><project>
<id>2592</id><title_hr><![CDATA[Likovna umjetnost i komunikacija moći u razdoblju ranoga novoga vijeka (1450.-1800.) : povijesne hrvatske regije na razmeđi Srednje Europe i Mediterana]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3481</user_id><user_firstLast_name>Mirjana Repanić-Braun</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-7397</code><acronim><![CDATA[VACOP]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Povijest umjetnosti, </scie_field_hr><scie_field_en>Art history, </scie_field_en><institution_hr><![CDATA[Institut za povijest umjetnosti]]></institution_hr><institution_en><![CDATA[Institute of Art History, Zagreb]]></institution_en><team_members_id>4586</team_members_id><team_members_names><![CDATA[ Doktorand: Petra Batelja ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Art, Politics, Communication, Croatia, Early Modern period]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[This research will primarily focus on the analysis andinterpretation of the relation of pow er holders tow ard the visualarts in Croatian regions of the Early Modern Period, as w ell asthe places and the media of their transmission. In the spirit ofnew art history, the research w ill seek to answ er the follow ingquestions: 1. w hich media channels – including communicationmeans and strategies – did certain centres of pow er use tocreate and promote favourable responses among differenttypes of recipients in Croatia of the early modern period? 2.w hat w as the role of visual art in shaping public opinion and thesocial promotion and re(presentation) of pow er holders? Thepow er holders in Croatian regions w ho acted as artcommissioners w ere primarily from the ranks of the aristocracy(both secular and ecclesiastical) – representatives of the stateideologies of the Venetian Republic, the Kingdom of Hungary,the Habsburg Monarchy and the Dubrovnik Republic. In additionto them, there w ere also local corporate patrons and artcommissioners – confraternities – w hich mainly reflected theinterests of local communities. Those art commissioningchannels made possible cultural transfers in visual arts andarchitecture in the Croatian territory during the period from theearly Renaissance to the late Baroque. The research w illfacilitate the creation of a database containing relevant visualrecords of the aforementioned historical period, w hich w illenable a comparative analysis of the phenomenon from theperspective of the sociology of culture, critical iconology andsemiotics. Finally, this w ill result in the development of anappropriate model for the understanding and interpretation ofthe specific usage of visual arts as mediator in thecommunication of pow er in Croatia of 1450-1800.]]></summary_en></project><project>
<id>2593</id><title_hr><![CDATA[Ekološki pristup projektiranju broda i optimalnom planiranju rute]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4256</user_id><user_firstLast_name>Jasna Prpić-Oršić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-2582</code><acronim><![CDATA[GASDORP]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Brodogradnja, </scie_field_hr><scie_field_en>Naval architecture, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Tehnički fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Engineering]]></institution_en><team_members_id>19041</team_members_id><team_members_names><![CDATA[ Doktorand: Natalija Vitali ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[seakeeping, ship speed, ship resistance, ship propulsion, fuel consumption, GHG emission, weather routing]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The accurate calculation of attainable ship speed at actual sea is essential from economical and also environmental aspects. Reliable ship speed loss estimation under real environmental conditions allows a more accurate prediction of the power increase and fuel consumption as well as gas emissions from ships. Nowadays this second issue becomes very important because of the problem of global warming. Following the increasing awareness of the environmental and human health concerns of shipping, legislative actions have been taken on global and national levels making mandatory (from January 1st 2013) that new ships over 400 gross tonnage, to comply with the regulations, should have emissions of CO2 under limiting value. Technological enhancement to ships like improved hull designs as well as improvement in power and propulsion systems could potentially reduce CO2 emission up to 35 %. These measures could effectively be combined with several other operational measures, such as weather routing and voyage planning, in order to ensure that fuel consumption and CO2 emissions from ships are minimized on every voyage.The proposed research will be conducted in three main areas: 1. Improvement of the methodology of ship speed, fuel consumption and greenhouse gases (GHG) emissions (especially CO2) calculation on actual weather conditions, 2. Optimization of the ship hull (bow and stern) and ship propulsion system operating in actual weather condition, 3. Optimization of ship route by taking into account all relevant parameters: weather prediction, attainable ship speed on waves, main engine performance and navigation constrains. The objective is to improve ship design and performance taking into accounts the environmental issue, creating a so called eco-efficient or “green” ship design. The project team consists of the scientists who are experts in the naval architecture, mechanical engineering and marine engineering field which allow solving this problem multidisciplinary. ]]></summary_en></project><project>
<id>2594</id><title_hr><![CDATA[Stohastičke metode u analitičkim i primijenjenim problemima]]></title_hr><title_en><![CDATA[]]></title_en><user_id>145</user_id><user_firstLast_name>Zoran Vondraček</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-3394</code><acronim><![CDATA[SMAAP]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>19109</team_members_id><team_members_names><![CDATA[ Doktorand: Hrvoje Planinić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[stochastic methods, stochastic processes, Markov processes, martingales, heavy tails, point processes, branching processes]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[In this project we apply modern stochastic methods to study a number of analytical and applied problems. Many phenomena in science and everyday life exhibit inherent uncertainty. We commonly use stochastic models to describe such behaviour and rely on stochastic methods to gain insights, make forecasts or inference about them. Various stochastic methods have appeared over the years in biology, medicine, biomedicine, geology, climatology, social sciences, finance and insurance, and many other scientific fields. The area of mathematics that lies in the background is probability theory, in particular, theory of stochastic processes. It is a rich mathematical theory with proven potential to solve not only applied problems, but also some quite theoretical problems coming from other areas of mathematics.The problems that we plan to study can be broadly divided into four groups: 1. Analysis and potential theory of Markov processes, 2. Stochastic methods in modelling heavy tailed phenomena, 3. Stochastic methods in harmonic analysis, and 4. Stochastic methods in biomedical and social sciences problems. This choice of problems is influenced by importance in the current international research as well as the background and expertise of members of our team. The goal of the project is to advance understanding of the role of randomness in each of these four settings. The unifying feature behind our approach to these problems is common stochastic methods in their analysis. These methods include, but are not limited to, martingale methods, point processes and random measure methods, potential-theoretic methods (both probabilistic and analytic), Markov processes methods, methods from the Dirichlet form theory, stochastic integrals, diffusion processes, branching processes and measure-valued processes methods, time-series methods, wavelets and methods for statistical inference.]]></summary_en></project><project>
<id>2595</id><title_hr><![CDATA[OIKONET- A Global Multidisciplinary Network on Housing Research and Learning ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>7459</user_id><user_firstLast_name>Gojko Bežovan</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-7086</code><acronim><![CDATA[]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Socijalne djelatnosti, </scie_field_hr><scie_field_en>Social work, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Pravni fakultet u Zagrebu]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Law]]></institution_en><team_members_id>17734</team_members_id><team_members_names><![CDATA[ Doktorand: Josip Pandžić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>2596</id><title_hr><![CDATA[Genetska osnova količne bioaktivnih hranivih tvari hrvatskih populacija graha]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1294</user_id><user_firstLast_name>Klaudija Carović-Stanko</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-2895</code><acronim><![CDATA[BeanQual]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Biotehnologija, </scie_field_hr><scie_field_en>Biotechnology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Agronomski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Agriculture]]></institution_en><team_members_id>17838</team_members_id><team_members_names><![CDATA[ Doktorand: Monika Vidak ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Phaseolus vulgaris L., nutrients, bioactive substances, molecular markers, genetic diversity, association mapping]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Common bean is a valuable legume for human consumption worldwide, being an important source of proteins, vitamins and minerals with considerable potential as a functional food. However, the increased mineral content in the diet does not guarantee increased mineral status for consumers and consequently mineral malnutrition is one of the global health concerns. Phytic acid (PA) acts as antinutritive compound by binding mineral cations and forming mixed salts. PA is also the main storage molecule for phosphorus and it is essential for normal seed development and germination. Seed mineral and PA content varies widely among bean genotypes. In Croatia bean is traditionally grown in low input production systems. The production is based on landraces which are adapted to local environments and display high levels of morphological diversity. A broad variability is also expected in seed bioactive nutrient content as well as on genetic level. Through international collaboration on Phaseolus genomics, a lot of information has become available including genetic linkage maps, microsatellite databases and a massive number of single nucleotide polymorphisms (SNP) sequences. In proposed project an integrated approach will be used to characterize bioactive nutrient variability and the inherent genetic diversity. In conjunction with a detailed data on bioactive nutrient content, a whole genome association mapping analysis will be carried out in order to identify quantitative trait loci (QTLs) related to bioactive nutrient content. Success in bean breeding for higher quality relies on the availability of information on bioactive nutrient content and the knowledge of genetic bases of quality trait variability. The integration of fundamental (molecular genetics) and applied (plant nutrition, plant breeding) sciences will facilitate the management of traditional landraces as sources of bioactive nutrients in future breeding programs based on marker-assisted selection (MAS).]]></summary_en></project><project>
<id>2597</id><title_hr><![CDATA[UNESCO-ova katedra za slobodno kretanja osoba, migracije i interkulturalni dijalog (UNESCO Chair on Free Movement of People, Migration and Inter-Cultural Dialogue)]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5506</user_id><user_firstLast_name>Iris Goldner Lang</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-7630</code><acronim><![CDATA[]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Pravo, </scie_field_hr><scie_field_en>Law, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Pravni fakultet u Zagrebu]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Law]]></institution_en><team_members_id>17811</team_members_id><team_members_names><![CDATA[ Doktorand: Nika Bačić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>2599</id><title_hr><![CDATA[PRIMJENA PLAZME STVORENE VISOKONAPONSKIM ELEKTRIČNIM PRAŽNJENJEM  PRI KONZERVIRANJU TEKUĆE HRANE ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>206</user_id><user_firstLast_name>Zoran Herceg</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-3102</code><acronim><![CDATA[NTP01]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Prehrambena tehnologija, </scie_field_hr><scie_field_en>Food technology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Food Technology and Biotechnology]]></institution_en><team_members_id>590</team_members_id><team_members_names><![CDATA[ Doktorand: VIŠNJA STULIĆ ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Electrical discharge plasma, liquid-phase plasma reactor, liquid food, physico-chemical properties, nutritional and sensory properties]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[With the growing knowledge of the importance of food in maintaining the human health, the food industry is faced with increasing challenges to develop new non-thermal food treatment technologies that would prevent and mitigate food contamination while retaining nutritional and functional properties of the treated food. Electrical discharge plasma is one of these more promising techniques. Plasmas formed directly in liquid inactivate microorganisms and without significant increase in temperature during the treatment. However, knowledge gaps regarding the nature of sterilization, inactivation mechanism and the plasma reactor design have been identified as major constraints for the applicability of this technology in food industry. Thus the main goal of the proposed project is to design and develop a non-thermal plasma reactor for the treatment of fruit juices and milk and optimize it to maximize the utilization of UV light and chemical species produced by plasma.  To achieve this goal, we propose to address the following research objectives (R):R1     Develop and optimize a liquid-phase plasma reactor for treatment of fruit juices and milk.R2       Characterize the chemical and electrical properties of the liquid plasmas. R3  Evaluate the ability of the liquid-phase plasma to inactivate pathogenic microorganisms in suspensions of pure culture microorganisms and suspended in fruit juices and milk respectively. R4       Determine inactivation mechanism of the plasma treatments on microorganisms R5      Determine the effect of the plasma treatments on the physico-chemical, nutritional and sensory properties of juices and milk.The significance of the proposed research lies in the development of a novel plasma reactor as well as acquires new knowledge regarding the science behind the forthcoming plasma technology which can then be applied towards introducing and potentially replacing current processing technologies with plasma.]]></summary_en></project><project>
<id>2600</id><title_hr><![CDATA[Notch u diferencijaciji hematopoetskih stanica matica i u razvoju leukemija]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3576</user_id><user_firstLast_name>Maja Matulić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-9845</code><acronim><![CDATA[NOBLE]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>17773</team_members_id><team_members_names><![CDATA[ Doktorand: Luka Horvat ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[ hematopoietic stem cells, leukemia, Notch, Ikaros, non-coding RNA,differentiation, ]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The relevance of adult (somatic) stem cell research is increasing steeply with a growing number of human diseases shown to be curable by stem cell therapy. The present study plan aims the research towards the gene regulatory mechanisms that control hematopoietic stem cell (HSCs) homeostasis and differentiation, which is tightly regulated by an interplay of a number of transcription factors and environmental signals mediated by a Notch signaling pathway. Our group designed an experimental approach for studying the interaction of Notch signaling pathway with transcription factor genes associated with hematopoiesis with focus on Ikaros gene family. Our laboratory has established a diagnostic technique for quick and sensitive detection of aberrant Notch and Ikaros forms by single cell multiplex qRT-PCR, which is a unique tool enabling us to dissect the contribution of different members of the Ikaros and Notch families on differentiation and survival of hematopoietic cells in a context of regulation of expression of target genes as well as non-coding RNAs, since they maintain the spatial organization of chromosome structure and regulate cell commitment. Our results will improve diagnosis and risk stratification for leukaemia patients which will be an important aid in informed clinical decisions. Therefore the proposed project will substantially advance the field towards better therapeutic options and contribute significantly to the field of stem cell medicine. ]]></summary_en></project><project>
<id>2601</id><title_hr><![CDATA[Kromatografsko pročišćavanje biomolekula i njihova karakterizacija]]></title_hr><title_en><![CDATA[]]></title_en><user_id>102</user_id><user_firstLast_name>Beata Halassy</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-8915</code><acronim><![CDATA[CHROBIO]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu]]></institution_hr><institution_en><![CDATA[University of Zagreb]]></institution_en><team_members_id>17755</team_members_id><team_members_names><![CDATA[ Doktorand: Dora Sviben ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[chromatography, viruses, plasma proteins, snake venom, monoliths, bioanalytics, aggregation]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Aim of the proposed research is the design of non-invasive chromatographic methods suitable for purification and concentration of biomolecules (viruses and proteins) and their characterization. Purification and analysis methods will be focused on measles virus, snake venom and antivenom proteins, and human plasma proteins. Measles virus is used as a vaccine and is found very suitable as a gene vector and as an oncolytic virotherapeutic, with the last two applications requiring large amounts of the virus. Venom is an antigen for antivenom production and both require careful analysis in order to obtain the final product of high quality. Proteins from plasma, namely albumin and immunoglobulin, are of great medical importance and their purification and stability are of utmost significance. All these biomolecules are important as biotechnological products and are subjected to rigorous quality requirements to ensure their safe usage. Therefore, non-invasive purification methods upgrading their quality and sustainable production and ensuring stability of these fragile biomolecules are essential. This project will base purification on chromatography using monolith stationary phases which are featured by their suitability for biomolecules due to high porosity, high binding capacity and convective based transport. Ion-exchange and affinity chromatography will be employed and various conditions tested for obtaining target material with high purity and yield. Also, various formulation conditions enabling preservation of virus viability and protein functionality and stability throughout the process will be tested. The analysis of the virus infectivity and protein functionality, removal of contaminants and the overall procedure effectiveness will be done by classical biochemical and virological methods as well as by some novel methods such as nanoparticle analysis that enables detection of virus and protein aggregates (NanoSight).]]></summary_en></project><project>
<id>2606</id><title_hr><![CDATA[Konceptualiziranje nacije i kolektivnih identiteta u Hrvatskoj: Politički rituali i kulturalna memorija trauma 20. stoljeća]]></title_hr><title_en><![CDATA[]]></title_en><user_id>2671</user_id><user_firstLast_name>Vjeran Pavlaković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-1936</code><acronim><![CDATA[FRAMNAT]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Povijest, </scie_field_hr><scie_field_en>History, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Filozofski fakultet u Rijeci]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>17786</team_members_id><team_members_names><![CDATA[ Doktorand: Renato Stanković ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Cultural memory, war, discourse analysis, collective identity, media]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Commemorations and other political rituals are key components of a nation’s cultural memory, crucial for the construction and reinforcement of ideological, ethnic, economic, gender, and other identities. FRAMNAT will involve a dynamic team of young scholars and develop innovative methodologies for cultural memory research and cognitive linguistics analysis relevant for Croatia’s academic and policy-making community, as well as a much broader transnational audience. Croatia’s commemorative culture regarding the wars of the 20th century serves as a platform for politicians to operate within the nation-building narratives. Our project will analyze both top-down and bottom-up strategies of framing the nation and collective identities through commemorative practices of World War Two and the Homeland War in Croatia.  These discourses will be analyzed at three levels: top-down political discourse (elites), media representation and transmission, and the reception of the narratives in Croatian society (bottom-up reactions). Seven commemorations related to World War 2 and the Homeland War will be observed and analyzed using corpus-based linguistic analysis and frame analysis. The media representations of the commemorative events and opinion poll data will likewise be analyzed in order to map how these discourses are transmitted and received in Croatian society. The project results will be disseminated via a regularly updated website (which includes a database of the collected research materials), journal articles, an edited volume, and papers presented at international conferences. Students and other members of the scholarly community will be encouraged to participate in the project through a variety of workshops to be held at the University of Rijeka. The long-term goal is to develop a Cultural Memory Research Center with scientific methods which can be applied to other regional and international case studies.    ]]></summary_en></project><project>
<id>2609</id><title_hr><![CDATA[ANAGENNISI - Innovative Reuse of All Tyre Components in Concrete]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3406</user_id><user_firstLast_name>Nina Štirmer</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-1679</code><acronim><![CDATA[]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Temeljne tehničke znanosti, </scie_field_hr><scie_field_en>Basic engineering sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Građevinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Civil Engineering]]></institution_en><team_members_id>17806</team_members_id><team_members_names><![CDATA[ Doktorand: Martina Pezer ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>2610</id><title_hr><![CDATA[Ekonomski, statistički i politički aspekti tržišta državnih obveznica]]></title_hr><title_en><![CDATA[]]></title_en><user_id>603</user_id><user_firstLast_name>Maruška Vizek</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-9058</code><acronim><![CDATA[SOBOM]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, </scie_field_hr><scie_field_en>Economy, </scie_field_en><institution_hr><![CDATA[Ekonomski institut Zagreb]]></institution_hr><institution_en><![CDATA[Institute of Economics in Zagreb]]></institution_en><team_members_id>17742</team_members_id><team_members_names><![CDATA[ Doktorand: Petra Palić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Sovereign bond market, sovereign spreads, volatility spillovers, sovereign bond market integration stochastic volatility models, extreme value theory,]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Recent developments related to the Eurozone debt crisis clearly demonstrated the inability of the literature to provide a theory and associated empirical models that can explain the past and predict the future sovereign bond yield changes. Therefore in this research we investigate the features of the sovereign bond markets that are either underexplored or the literature offers conflicting findings. We focus specifically on bond markets in all EU member states and the US, and differentiate seven research segments that are mutually interrelated. First segment applies GARCH-type models and estimates sovereign bond spread volatility and the volatility risk premium. The output of this segment is used in subsequent segments; in the model of spread determinants, volatility spillovers, and capital flight. Second segment is dedicated to the analysis of the statistical properties of sovereign spreads volatility by an application of extreme value theory, self-exciting and Markov switching models. We quantify extremal dependence between spreads and the distribution of  clusters of their extreme movements using the extremogram. Two segments are devoted to the analysis of volatility spillovers across bond markets and time-varying degree of sovereign bond market integration in developed and emerging EU countries. We also analyze political factors that may influence the sovereign bond market and cross-border capital movement. In this segment we code political variables employed as explanatory variables in the remaining two segments. Hence segment six estimates the model of spread determinants that includes a more balanced and detailed representation of market sentiment and volatility, fiscal features, and political factors. Due to the fact that in recent times extreme changes in sovereign bond markets induced cross-border reallocation of the capital, in the seventh segment we estimate a capital flight model that includes political factors and sovereign spread volatility premium.]]></summary_en></project><project>
<id>2613</id><title_hr><![CDATA[Eksperimentalno potpomognuti razvoj naprednih modela izgaranja motora s unutarnjim izgaranjem ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>11160</user_id><user_firstLast_name>Darko Kozarac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-5314</code><acronim><![CDATA[]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, </scie_field_hr><scie_field_en>Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>17793</team_members_id><team_members_names><![CDATA[ Doktorand: Mario Sremec ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>2614</id><title_hr><![CDATA[Mjerenje svojstava Higgsovog bozona i potraga za novom fizikom detektorom CMS]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4052</user_id><user_firstLast_name>Ivica Puljak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-2568</code><acronim><![CDATA[HIGGSPRO]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Fakultet elektrotehnike, strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Electrical Engineering, Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>19070</team_members_id><team_members_names><![CDATA[ Doktorand: Toni Šćulac ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[CMS detector, LHC, Higgs boson, leptoquarks, electron reconstruction]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The discovery of a Higgs boson by the ATLAS and CMS experiments at the LHC has opened a new era for particle physics, namely precision consistency tests of the SM Higgs boson. The proposed project has two main goals: measurement of the SM Higgs boson properties, as the window for the search for new physics beyond the Standard model, and a direct search for new physical phenomena looking for hypothetical particles called leptoquarks. In the first year of project we will explore the data collected by the CMS experiment during 2011 and 2012, while preparing for the LHC Run II, which is expected to start in 2015. Preparation consists of developing and implementing new electron reconstruction, identification and isolation algorithms, which will be used by the whole collaboration when the new data taking starts.  During the second year of the project we will commission and maintain electron reconstruction algorithms, start collecting the data and make first analysis at new energy. During third and fourth year we will explore the data and concentrate to the two main goals of the project: SM Higgs boson properties measurements and search for new physics. ]]></summary_en></project><project>
<id>2615</id><title_hr><![CDATA[Inženjering kristalnih materijala pomoću metalnih kompleksa i nekovalentnih interakcija]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1229</user_id><user_firstLast_name>Marijana Đaković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-9090</code><acronim><![CDATA[CRYSTIN]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>17739</team_members_id><team_members_names><![CDATA[ Doktorand: Mladen Borovina ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[crystal engineering, non-covalent interactions, supramolecular architecture, synthons, metal complexes]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Interdisciplinary research at the interface of chemistry and materials science has been remarkably successful at producing technologies that have revolutionized all aspects of everyday life.  However, there is still a great need for new solids with ‘improved’ physical properties (faster, cheaper, smarter or more responsive than current alternatives). Unfortunately, the ability to ‘dial-in’ a property or physical response remains a major challenge. Therefore, our goal is to establish reliable avenues for the design of crystalline metal-containing materials by encoding building-blocks with structural-preferences that lead to ‘programmable’ assembly, thus avoiding serendipity and chance when targeting new materials with specific and tunable properties. To achieve this, we first need to map out the structural landscape that controls how metal complexes communicate and subsequently assemble into 3-D architectures.We will explore and quantify the interrelationship between ligand-field splitting energy, coordination geometry, metal-ligand dimensionality, ligand flexibility, and supramolecular assembly, one variable at a time, using a combination of experiment and theory.  This will enable us to map out the structural landscape defined by metal(II) complexes (Co, Ni, Cu and Cd) and custom-made ligands decorated with functionalities that are known to form reliable supramolecular synthons in organic solids.New structural and spectroscopic information will be complemented by data obtained by mining the CSD, while computational methods will inform both the planning as well as the interpretation of the experimental efforts. The results obtained in this systematic and multidisciplinary research program will create new avenues towards the design of crystalline metal-containing materials based on reliable structure-activity protocols.]]></summary_en></project><project>
<id>2616</id><title_hr><![CDATA[Modeli i metode upravljanja inovacijama u razvoju kompleksnih inženjerskih sustava]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4471</user_id><user_firstLast_name>Mario Štorga</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-2035</code><acronim><![CDATA[MInMED]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, </scie_field_hr><scie_field_en>Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>17795</team_members_id><team_members_names><![CDATA[ Doktorand: Marija Majda Perišić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[innovation dynamics, knowledge management , socio-technical systems, complex networks, engineering systems development]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The goal of the proposed research project is to develop a set of fundamental models and methods for innovation management within and across hierarchical social networks exiting in contemporary private and public R&D organisations, and to explore and develop analyse and simulation tools for quantifying knowledge and information dynamics as a mean for prediction of the future trends in organisational innovation. The context of the socio-technological framework that transcends the organisational innovation dynamics within contemporary engineering systems and services life-cycle requires the research overriding commitment to methodological pluralism. The integrated analyse – evaluate - create – refine - validate approach will be used as research methodology.The research will build on state of the art developments in the exploration of principles of knowledge management for R&D organisations and will go further; in that it will seek to incorporate the insights from modelling, simulation and visualisation of the complex social, natural and technical systems to the knowledge and information dynamics that encompass the generation, storage, dissemination, filtering, and reprocessing of innovation across hierarchical socio-technological networks. The research effort will entail the development of concepts, theories, metrics and case studies related to the R&D organisational innovation management. The controlled experiments in real-world private and public R&D organisations will be used in research to gain valuable insights across different sectors (automotive, aerospace, energy, transportation, healthcare, public administration, etc.).It is expected that the results of the proposed research will provide valuable interdisciplinary contributions and improve overall understanding respective to the organisational innovation.]]></summary_en></project><project>
<id>2619</id><title_hr><![CDATA[Upotreba cijelog genoma mitohondrijske DNA u oplemenjivanju i konzervacijskoj genetici goveda]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6650</user_id><user_firstLast_name>Ino Čurik</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-8455</code><acronim><![CDATA[MitoTAUROmics]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Agronomski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Agriculture]]></institution_en><team_members_id>19007</team_members_id><team_members_names><![CDATA[ Doktorand: Vladimir Brajković ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Whole mitogenome, Cattle, Detrimental effects, Phenotypic variability, Quantitative genetics]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The main goal of this proposal is to sequence mitochondrial whole genome (mtWGS) in a 500 to 600 bulls or cows (440 to 540 belonging to Istrian cattle, Busha cattle, Slavonian-Syrmian Podolian cattle and Holstein population in Croatia) in order to: 1). identify polymorphic sites within mtWGS in genetically small populations and to analyse (confirm) the presence of selection for the whole mitochondrial genome as well as for each single gene (comparison of non-synonymous versus synonymous mutations); 2). Identify potentially detrimental mutations and to estimate detrimental load in all analysed populations; 3.) develop computerised approach (set of algorithms) that will, in terms of probability or likelihood, enable imputation of sequenced mtWGS haplotypes for other pedigree members as well as to point to animals that are wrongly assigned to the pedigree, 4.) Identify mutations that are associated with phenotypic variability of milk production and fertility traits and to estimate the magnitude of the mtWGS effects (haplotypes) in terms of variance components and 5.) Identify private (specific) mutations that can be used in traceability or genetic bar-coding of species and breeds (this is of particular interest for endangered populations). In performing these comprehensive analyses we will use newly developed methodologies of high-throughput sequencing and complex computing analyses. We believe that this research will stimulate other researchers involved in animal genetics and breeding of other species (dog, horse, swine, rabbit, etc…) for similar researches. Furthermore, results of the project will be economically utilised in cattle breeding as well as conservation management of endangered Croatian breeds. At the same time, we hope that innovative and technologically advanced component of this research will result in good publication record for all scientists involved which will further increase our competitiveness to approach to EU funded projects.]]></summary_en></project><project>
<id>2620</id><title_hr><![CDATA[Održiva proizvodnja bioetanola i biokemikalija iz otpadnih poljoprivrednih lignoceluloznih sirovina]]></title_hr><title_en><![CDATA[]]></title_en><user_id>450</user_id><user_firstLast_name>Tonči Rezić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-4937</code><acronim><![CDATA[SPECH-LRM]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Biotehnologija, </scie_field_hr><scie_field_en>Biotechnology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Food Technology and Biotechnology]]></institution_en><team_members_id>17840</team_members_id><team_members_names><![CDATA[ Doktorand: Martina Andlar ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[bioetahnol, lactic acid, physiological active oligosaccharides, lignocellulosic raw materials, integrated bioprocess, mathematical modeling, LCA]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The aim of this project proposal is the development of sustainable bioprocesses for the production of bioethanol and biochemicals [lactic acid (LA) and physiologically active oligosaccharides (PAO)] from agricultural waste lignocellulosic raw materials (e.g. wheat straw, corn stover and cob, onion peels, cocoa husks, pea pods, walnut shells and sugar beet pulp). All these agricultural byproducts are abundant, cheap, non-food competing and renewable polysaccharide-based feedstocks.  In this project, agricultural waste lignocellulosic raw materials will be hydrolyzed by thermal, chemical or enzymatic methods or their combinations in order to obtain adequate disintegration of raw materials. Studies of bioethanol and LA production will be performed by the semi-solid or solid state fermentation in the new constructed horizontal rotating tubular bioreactor (HRTB). The most suitable microorganisms for bioetahnol and LA production will be identified and improved by genetic methods. Studies regarding suitable purification methods for all three bio-products will be performed in order to obtain pure compounds for theirs further practical use. Integration between production and separation bioprocess stages will be also examined in order to improve ecological and economical aspects of these bioprocesses. The sustainability of bioethanol and LA production will be evaluated through the realization of Life Cycle Assessment (LCA). The most efficient and sustainable bioprocess configuration will be determined and consequently scale-up procedure will be proposed. The scale-up procedure will be based on the developed integral bioprocess mathematical model and other scale-up criteria. Project outcomes will be new integrated bioprocesses for the transformation of agricultural waste lignocellulosic raw materials into high added value products.]]></summary_en></project><project>
<id>2621</id><title_hr><![CDATA[Metode deidentifikacije za meke i ne-biometrijske identifikatore]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6564</user_id><user_firstLast_name>Zoran Kalafatić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-9838</code><acronim><![CDATA[DeMSI]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>6563</team_members_id><team_members_names><![CDATA[ Doktorand: Ivan Filković ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[De-Identification, Privacy Protection, Image Processing, Video Processing, Biometrics, Multimedia]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Advances in audio and video recording devices, web technology and signal processing have highly facilitated the efficacy of audio and video acquisition. This capability is now widely exploited in a variety of scenarios to obtain audio-video recordings of people, raising serious privacy concerns. The protection of sensitive private data is required by EU’s Data Protection Directive (95/46/EC). De-identification in multimedia content can be defined as the process of concealing identities of individuals captured in a given set of data, for the purpose of protecting their privacy. Soft biometric and non-biometric characteristics such as tattoos, birthmarks, scars or dressing style also carry potentially identity-revealing information and have to be dealt with in the process of de-identification. This is an interdisciplinary challenge, involving such scientific areas as image processing, video tracking and biometrics. This project proposal aims to development of novel and robust methods for de-identification of soft and non-biometric identifiers in videos and images.]]></summary_en></project><project>
<id>2622</id><title_hr><![CDATA[Europska bioetika na djelu]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4099</user_id><user_firstLast_name>Amir Muzur</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-2024</code><acronim><![CDATA[EuroBioAct]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Medicine]]></institution_en><team_members_id>5496</team_members_id><team_members_names><![CDATA[ Doktorand: Robert Doričić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Europe, integrative bioethics, Fritz Jahr, ecology, environment, Northern Adriatic]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The „European Bioethics in Action (EuroBioAct)” project primarily aims at:	1. completing theoretical basis for the „new European bioethics“ (by rounding-up 	research on Fritz Jahr, Ignaz Bregenzer, and other thinkers and conceiving a 	common platform with integrated ideas of modern environment science and 	ethics) and	2. applying that theoretical basis in practice (by compiling a list of „bioethical 	standards“ for settlements, containing concrete general and specific norms for 	preservation and improvement of local eco-systems – i.e., human health, animal 	and plant welfare, etc.).In the first phase of the project realisation, the participants would continue with the broadening and deepening of the theoretical basis of the „new European bioethics“ primarily by completing the research of the life and work of Fritz Jahr and his most important models (Ignaz Bregenzer and others). In the second phase of the project, three focused workshops would be organised determining the status of the general and special ecological needs for the three local communities (Plomin, Bakar, and Mali Lošinj) from the Northern Adriatic region. The three communities selected to host the workshops have either been recently experiencing ecological threats (Plomin – thermo-electric power plant; Bakar – cokery), or represent a highly-valuable and vulnerable natural insular pocket (Mali Lošinj – health tourism, dolphin wildlife refuge, fragrant gardens programme, etc.). Based on the theoretical background and the insights provided by the workshops, in the third phase of the project, created would be the „bioethical standards“, that is, a set of principles and measures of the correct relation of men toward their own health, animals, plants, and the eco-system in total. A „bioethical standards“ charter might improve the level of local community environmental consciousness, and provide direction lines for its sustainable development (including a potential tourism-advertising ace card).]]></summary_en></project><project>
<id>2623</id><title_hr><![CDATA[Epigenetičke promjene karcinoma pločastih stanica glave i vrata]]></title_hr><title_en><![CDATA[]]></title_en><user_id>572</user_id><user_firstLast_name>Magdalena Grce </user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-3542</code><acronim><![CDATA[EpiC-HNSCC]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>17822</team_members_id><team_members_names><![CDATA[ Doktorand: Ksenija Božinović ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[methylation, microRNA, HPV, head and neck cancer, biomarker]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Head and neck squamous cell carcinoma (HNSCC) is the sixth most common malignancy worldwide. Despite aggressive treatment of HNSCC patients, which entails surgery, chemo- and radio-therapy, the five-year survival is only 40-50%. Tobacco, alcohol, microbial factors (high-risk human papillomaviruses, hrHPVs), systemic factors (immunosuppression, micronutrient deficiency) and UV-radiation are common risk factors for development of HNSCC. HNSCC patients with HPV infection were found to have better prognosis and treatment response. Besides the HPV status, no adequate biomarkers have been found so far to predict the poor/good clinical outcome nor is the mechanism of how HPV modulates therapy response fully understood. Epigenetic changes such as DNA methylation of specific gene promoters and posttranscriptional modification of gene expression by specific microRNA (miRNA) seems to be promising biomarkers of disease occurrence and progression. Therefore, the primary objective of this project is to identify novel specific epigenetic biomarkers to predict early-stage of HNSCC, notably oral and oropharyngeal cancer, patients at greater risk for developing invasive cancer, and finally understand treatment response in patient with HPV-associated cancers. State-of-the-art technologies, wide-genome microarray assay and types-specific validation of DNA methylation and miRNA profiles (methylome and mirome, respectively) will be used on subsets of healthy tissue, HPV-related and HPV-unrelated precancerous oral lesions, oral and oropharyngeal cancer, and metastasis. The integration of all findings should yield ideal epigenetic biomarkers. This project is a comprehensive interdisciplinary research, which includes basic and clinical research, and will enable the improvement of existing knowledge, development of new technological approaches in diagnostics and prognostics, and possible new treatment approach for oral and oropharyngeal cancer.]]></summary_en></project><project>
<id>2624</id><title_hr><![CDATA[Identifikacija i funkcionalna karakterizacija (eko)toksikološki važnih polispecifičnih membranskih transportnih proteina u zebrici (Danio rerio)]]></title_hr><title_en><![CDATA[]]></title_en><user_id>986</user_id><user_firstLast_name>Tvrtko Smital</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-7922</code><acronim><![CDATA[TRANS-ZEBRATOX]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>17738</team_members_id><team_members_names><![CDATA[ Doktorand: Jelena Dragojević ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[polyspecific uptake and efflux transporters, zebrafish, identification, functional characterization, knockout studies, (eco)toxicological relevance ]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[A coordinated system of transport proteins, channels, receptors and enzymes act as cellular gatekeepers to foreign molecules, critically determining the so-called ADME-Tox (absorption, distribution, metabolism, excretion – toxicity) properties of a molecule. The polyspecific uptake and efflux transmembrane proteins are essential components of this complex cellular defense and detoxification/xenobiotic processing machinery in mammals, highly important and widely recognized in the context of pharmacology and human toxicology. However, they are scarcely investigated in non-mammalian species, and not adequately addressed in the field of environmental toxicology. Consequently, the major goal of the proposed project is identification and detailed functional characterization of new, potentially (eco)toxicologically relevant uptake and efflux transport proteins not addressed so far in the context of environmental toxicology, or in non-mammalian species in general. Our research will be focused on selected polyspecific uptake transport proteins from the SLC21 and SLC22 (Solute Carriers) proteins families, the efflux transporters from the MATE (multidrug and toxic compound extrusion proteins) family, and finally the RLIP76 as the most recently discovered stress-responsive, multi-functional membrane protein. We will use zebrafish (Danio rerio) as a highly relevant vertebrate research model, and our methodological approach will be based on several subsequent research phases: phylogenetic and gene expression analyses; transfection studies in appropriate heterologous expression system(s); transport-activity assays; analyses of the transport mechanism and structural properties; high-throughput-screening identification of chemical interactors of selected transporters among environmental contaminants; and finally in vivo evaluation of the (eco)toxicological relevance of selected transporters using the zebrafish functional genomics tools.]]></summary_en></project><project>
<id>2625</id><title_hr><![CDATA[Istraživaje prirodnih spojeva i aroma: kemijsko profiliranje i otkrivanje potecijala]]></title_hr><title_en><![CDATA[]]></title_en><user_id>367</user_id><user_firstLast_name>Igor Jerković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-3039</code><acronim><![CDATA[NaPro-Flav]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Kemijsko-tehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Chemistry and Technology]]></institution_en><team_members_id>3752</team_members_id><team_members_names><![CDATA[ Doktorand: Marina Kranjac ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[natural products, flavours, preparative techniques, chromatography, spectroscopy, antioxidant assays, corrosion inhibition assays]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The proposed project develops up-to date topic in the subject area, offers high-quality research of natural products (NPs) and flavours (FLs) and tends to impact the biodiversity, traceability and authentication issues of targeted samples (major EU concerns), as well as to unlock the potential (useful activities of the samples/NPs). Targeted samples are unexplored or insufficiently investigated honeys, honeydews, bee-products, wines, cheese, others. While characteristic NPs (secondary metabolites) already possess flavours, other flavour compounds can derive from precursors during processing, fermentation, dry-curing, heating, others (e.g. Maillard reactions, Strecker degradations, retro-aldol reactions, Amadori rearrangements, heterocyclizations, lipid oxidations and others). NPs/FLs isolation involves application of selective preparative procedures followed by the organic analysis applying modern chromatographic and spectroscopic techniques. Specific project goal is to determine reliable chemical fingerprints of targeted samples depending on biodiversity of natural sources in different regions. Varieties of acetate, shikimate, mevalonate and/or deoxyxylulose biosynthetic pathway derivatives are expected to be found. Among them, it can be possible to find specific or nonspecific chemical biomarkers characterizing certain sources. In addition, the obtained NPs or selected samples will be evaluated in order to unlock their potential, particularly antioxidant activity by different assays and corrosion inhibition potential with in-situ and ex-situ electrochemical/non-electrochemical techniques. Project work plan includes: 1) the samples selection and preliminary characterisation; 2) set-up of preparative/chromatographic/spectroscopic methods followed by elaboration of the obtained chemical fingerprints); 3) set-up of antioxidant/corrosion inhibition assays followed by unlocking the samples/NPs potential; 4) training of young researchers/cooperation.]]></summary_en></project><project>
<id>2626</id><title_hr><![CDATA[Primjena nanomaterijala u izradi potenciometrijskih tenzidnih senzora za primjenu u industriji i zaštiti okoliša]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4824</user_id><user_firstLast_name>Milan Sak-Bosnar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-8713</code><acronim><![CDATA[NANOSENS]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Odjel za kemiju]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Department of Chemistry]]></institution_en><team_members_id>17818</team_members_id><team_members_names><![CDATA[ Doktorand: MATEJA HAJDUKOVIĆ ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[surfactant, analysis, sensor, potentiometry, nanomaterial, environment, industry]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The project comprises development and construction of a nanomaterials-based potentiometric surfactant sensor, that will be used for measurement of ionic surfactants concentration in surfactant raw materials, consumer products, pharmaceutical and cosmetic products, environmental materials etc. The new sensor should eliminate the drawbacks of the standard time-consuming extraction-spectrophotometric procedures and classical polymer liquid membrane based sensors. It can be used as an end-point detector by potentiometric titration of ionic surfactants or by their direct potentiometric determination.The new sensor can be also used as a specific detector in microfluidic techniques such as Flow Injection Analysis (FIA), Sequential Injection Analysis (SIA), as well as in the separation techniques (HPLC), substituting in this way more expensive, larger nonspecific detectors such as optical and conductivity detectors etc.]]></summary_en></project><project>
<id>2627</id><title_hr><![CDATA[Establish Pan-European Information Space to Enhance seCurity of Citziens - EPISECC]]></title_hr><title_en><![CDATA[]]></title_en><user_id>11139</user_id><user_firstLast_name>Snježana Knezić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-6635</code><acronim><![CDATA[]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Temeljne tehničke znanosti, </scie_field_hr><scie_field_en>Basic engineering sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu Fakultet građevinarstva, arhitekture i geodezije]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Civil Engineering, Architecture and Geodesy]]></institution_en><team_members_id>17807</team_members_id><team_members_names><![CDATA[ Doktorand: Toni Kekez ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>2628</id><title_hr><![CDATA[Primjena nusproizvoda prehrambene industrije za razvoj funkcionalnih i okolišno prihvatljivih ekstrudiranih proizvoda i aditiva ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6031</user_id><user_firstLast_name>Drago Šubarić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-5131</code><acronim><![CDATA[FUNEXFOOD]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Prehrambena tehnologija, </scie_field_hr><scie_field_en>Food technology, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Prehrambeno-tehnološki fakultet]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Food Technology]]></institution_en><team_members_id>17789</team_members_id><team_members_names><![CDATA[ Doktorand: Jelena Panak ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Functional food, extrusion, cereals, flours, by-products, environment-friendly]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Consumers nowadays are seeking palatable food which has beneficial effect on health. At the same time, they are not ready to change their eating habits – reduce intake of bakery products, fast food etc. and increase intake of fresh fruit and vegetable, whole grain products etc. Therefore, food industry is challenged to create products that are consumed every day (bread, snacks etc.) by large population, which are both enriched with bioactive substances and have desired sensory properties.The aim of this project is to develop new functional and enriched products based on extrusion process. Enriched grains (wheat, maize) will be used as basic material. The improvement and supplementation with biologically active (antioxidants, minerals, vitamns, fibre) will be done by addition of by-products from food industry (fruit and vegetable pomaces, oil cakes) in extrusion process. Extrusion will be used to produce final products: expanded snack products and pasta, as well as modified flours which will be used in production of bakery products and biscuits.All processes - extrusion of snack products and pasta, extrusion for flour modification, pasta drying, baking) will be optimised using response surface methodology. All products will be tested for chemical, physical, thermophysical properties, and optimal products will be sensory analysed.The results of project will be array of flours and final products with defined recipes and optimal production conditions, along with defined application of food industry by-products that significantly load environment and are not currently exploited to satisfying extent.In the project multidisciplinary approach will be applied – from agronomist, over food technologist and process engineers to sensory experts. In addition, close academia-industry links will be developed through different activities.]]></summary_en></project><project>
<id>2629</id><title_hr><![CDATA[Advancing the European Multilingual Experience (AThEME)]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5463</user_id><user_firstLast_name>Tihana Kraš</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-4334</code><acronim><![CDATA[]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filologija, </scie_field_hr><scie_field_en>Philology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Filozofski fakultet u Rijeci]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>24274</team_members_id><team_members_names><![CDATA[ Doktorand: Maša Plešković ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>2631</id><title_hr><![CDATA[Poluvodički elementi visokih performansi  za primjene u sklopovima za bežične komunikacije i optičke detektore]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6955</user_id><user_firstLast_name>Tomislav Suligoj</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-2113</code><acronim><![CDATA[HiPerSemi]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>17830</team_members_id><team_members_names><![CDATA[ Doktorand: Sabina Krivec ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[semicoductors, microelectronics, bipolar transistors, photodetectors, photodiodes, CMOS, modeling, MOSFET, RF circuits]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The objective of this project is to provide notable scientific contributions by designing and utilizing the advanced semiconductor devices for the wireless communication circuits and solid-state optical detection applications. Research in this project will be grouped in three major activities, which are: (i) Horizontal Current Bipolar Transistor (HCBT) for RF Wireless Circuits, (ii) Characterization and applications of solid-state photodetectors, and (iii) Modelling of MOS, photodetector and other advanced electron devices. The novel wireless RF communication circuits such as mixer, frequency divider, voltage-controlled oscillator, RF switch and power amplifier will be designed and fabricated in HCBT technology as the first such circuits using the HCBT as an active component. The measurements of noise, reliability and on-wafer uniformity as well as linearity, gain and efficiency will be performed on transistors and circuits. The characterization of material properties of pure amorphous boron (PureB) layers will be made in order to determine the composition, electrical and optical properties of the layer and to develop the model of charge carrier transport through it. They will be correlated with electrical measurements to find out currently-unknown physical mechanisms responsible for the current reduction and for the record-high performance of photodides with PureB layers. The investigation of the novel materials such as Ge, SiGe and GaN for ultra-scaled advanced CMOS structures, i.e. FinFETs, will be performed by the development of novel models and simulation environment. The analog/RF parameters and characteristics will be extracted for FinFETs with different geometries and materials in order to determine the optimum structure for future RF systems.]]></summary_en></project><project>
<id>2632</id><title_hr><![CDATA[Komunikacije usmjerene čovjeku u pametnim mrežama]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5079</user_id><user_firstLast_name>Ivana Podnar Žarko</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-9476</code><acronim><![CDATA[HUTS]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>17866</team_members_id><team_members_names><![CDATA[ Doktorand: Martina Marjanović ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[smart network, big data, cloud communications, human computer interface, internet of things]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Human-centric Communications in Smart Networks (HUTS) project will address open questions regarding smart networks and human-centric communication in which data is both gathered from – and provided to – humans, anywhere and at any time, responding to their current needs. Through its research objectives, the project will investigate networking aspects of human-centric communication, such as the allocation and optimization of cloud and network resources and also providing related quality of service guarantees. This research will be used as a building block for various smart services, which enable user and device adaptation based on learning from previous situations and communicating the results of these situations. This powerful concept relies on new methods in cloud computing for big data processing and Internet-connected objects, such as smart sensors and actuators, as well machine-to-machine communication between devices using self-organizing ad-hoc networks. Smart services are further built upon innovative complex-service composition methodology and intelligent mechanisms to be formulated by the project. The introduction of smart services will drive the changes in the way people interact with devices towards more intuitive and unconstrained means. In particular, contactless user interaction, considering various categories of users, and networked virtual worlds/environments will be studied. Network data traffic models and network management will be proposed, including online charging mechanisms for dynamic pricing and cost calculation of smart services. The research proposed in this project will create new knowledge, strengthen research mentoring and improve young scientist capacities in Croatia, contribute results to science in the area of Information and Communication Technology, and help develop Croatian scientific and research space as one of the long-term strategic priorities, enabling knowledge transfer to Croatian economy for the benefit of society.]]></summary_en></project><project>
<id>2633</id><title_hr><![CDATA[Procjena i predviđanje produktivnosti šumskog ekosustava objedinjavanjem terenskih izmjera, daljinskih istraživanja i modeliranja]]></title_hr><title_en><![CDATA[]]></title_en><user_id>360</user_id><user_firstLast_name>Hrvoje Marjanović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-9721</code><acronim><![CDATA[EFFEctivity]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Šumarstvo, </scie_field_hr><scie_field_en>Forestry, </scie_field_en><institution_hr><![CDATA[Hrvatski šumarski institut]]></institution_hr><institution_en><![CDATA[Croatian Forest Research Institute]]></institution_en><team_members_id>17816</team_members_id><team_members_names><![CDATA[ Doktorand: Mislav Anić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[forest productivity, Quercus robur, GPP, NPP, eddy covariance, MODIS, Biome-BGC, photogrammetry, dendrometers, soil respiration]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Forest play important role in climate regulation and secure resources vital for local economy,  but the imminent climate change will affect their productivity, and for some tree species possibly even their sustainability. Thus, monitoring forest productivity and understanding effects of key environmental drivers becomes essential for forest management. This is a challenging task, particularly due to great costs related to it. Hereby we propose a research, aimed at addressing this issue, with a novel approach that could facilitate fast and cost-effective assessments of forest productivity. The research would be conducted on pedunculate oak forests (Quercus robur L.) which are economically, and ecologically, one of the most important in Croatia.  Main objective of the proposed research is to develop and test methods and workflows for the estimation of annual productivity of forests at the local scale by using existing research infrastructure for measurement of carbon fluxes (EC monitoring system), freely available high temporal resolution data from remote sensing (MODIS) and state of the art process model (Biome-BGC). The proposed research will provide the first evaluation on the quality of MODIS GPP and NPP estimates for Central-European lowland forests. Field measurement campaigns combined with state of the art digital photogrammetry will be performed to parameterise Biome-BGC model, and validate data from MODIS and model simulations. Using available data on future climate scenarion, productivity of oak forests for the future 30-50 years will be simulated with Biome-BGC model.   The proposed research is in line with the objectives of the EU Forest Action Plan which, among others proposes to encourage adaptation to the effects of climate change (key action 6), and to work toward a European Forest Monitoring System (key action 8).]]></summary_en></project><project>
<id>2634</id><title_hr><![CDATA[Održivi optički komunikacijski i senzorski sustavi zasnovani na rezonatoru s produženom rezonantnom šupljinom]]></title_hr><title_en><![CDATA[]]></title_en><user_id>7148</user_id><user_firstLast_name>Dubravko Babic</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-7862</code><acronim><![CDATA[EXCAR]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>19032</team_members_id><team_members_names><![CDATA[ Doktorand: Marko Šprem ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[optical access networks, WDM-PON, optical sensors, colorless optical transmitter, extended cavity, optical noise, noise reduction, wavelength re-use]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The objective of this project is to advance the state-of-the-art in optical access networks and also apply the same ideas to sensor networks. Proposed project addresses the EU targets as defined by European Commission’s “Europe 2020” strategy for smart growth by focusing on research and development of highly-integrated and energy efficient optical transceivers and wavelength-division-multiplexing (WDM) components for next-generation of access and mobile backhaul networks using passive optical network (PON) infrastructure. The primary challenge, in wider adoption of WDM-PON, lies in the development of sufficiently low cost technology to be used at the users’ premises. Self-seeded WDM-PON has been actively investigated in recent years as potentially the lowest cost solution for next-generation access networks. The primary attraction of this architecture is its simplicity, lower power consumption, and cost advantage. Similar principles can be applied to multiplexing and interrogation systems for optical sensors and our aim is to develop, analyze and demonstrate sustainable all-optical infrastructure based on extended cavity resonators able to provide physical layer for both, access communication and sensor networks.At University of Zagreb we invented an optical component, the modulation-averaging reflector, which reduces the penalty due to modulation of the seeding light and depolarizes the light oscillating in the cavity thereby stabilizing the extended resonator. This was the first step towards a future-proof optical access technology. Within this project we will fully develop and characterize systems based on extended cavity resonators with modulation averaging reflectors. We will also explore the use of modulation averaging concept in a novel communication optical source architecture based on wavelength re-use. Finally, the concept of extended cavity resonators will also be implemented in non-communication applications such as new optical sensor schemes.]]></summary_en></project><project>
<id>2635</id><title_hr><![CDATA[Upravljanje prostorno distribuiranim dinamičkim sustavima]]></title_hr><title_en><![CDATA[]]></title_en><user_id>7315</user_id><user_firstLast_name>Andrej Jokić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-7947</code><acronim><![CDATA[ConDis]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, </scie_field_hr><scie_field_en>Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>17859</team_members_id><team_members_names><![CDATA[ Doktorand: Mihael Lobrović ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[control systems, distributed control, optimization, large-scale systems, vibrations]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Following impressive developments in communication and information technologies, but also in sensor and actuator technologies, a whole set of novel products and systems has emerged, which only recently seemed unfeasible. Examples of such systems include the so-called smart structures composed of a large number of sensors and actuators mounted on constructive elements (beams/plates) with the goal to damp undesired vibrations or to control flow of fluids; adaptive optics with large amount of optical elements; smart electrical power systems; highways with automated cars driving in platoons. Common characteristic of all of the above mentioned systems is that they are composed of a large number of spatially distributed dynamical subsystems which operate under constant mutual interactions through some physical interconnections (network) and/or communication links (network). Today, it is widely acknowledged that the key challenge in development of such dynamical networks is synthesis of algorithms for their control. The main goal of this project is development of some of the key elements in fundamental theory of control for spatially distributed systems, together with constructive controller synthesis algorithms suitable for application in real-life problems. The research focus will be on distributed control solutions in which each dynamical system in the network is controlled by its local controller and each local controller communicates and coordinates its actions with a (usually small) set of directly neighboring controllers. Our approach will be based on innovative elements from the theory of dissipative systems, while both spatially invariant networks and generic dynamical networks with arbitrary interconnection graph will be considered. The developed control algorithms will be verified in laboratory experiments on groups of mobile robots and on a distributed vibration control platform.]]></summary_en></project><project>
<id>2636</id><title_hr><![CDATA[Općeslavenski lingvistički atlas (OLA) i Europski lingvistički atlas (ALE)]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3723</user_id><user_firstLast_name>Dunja Brozović Rončević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-4255</code><acronim><![CDATA[OLAALE]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filologija, </scie_field_hr><scie_field_en>Philology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zadru]]></institution_hr><institution_en><![CDATA[University of Zadar]]></institution_en><team_members_id>17864</team_members_id><team_members_names><![CDATA[ Doktorand: Ivana  Gmižić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[dialectology, linguistic atlas, linguistic maps, slavic languages, european languages]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The “General Slavic Linguistic Atlas” (OLA) and the “European Linguistic Atlas” (ALE) are long-term international linguistic projects. The OLA project involved research material derived from a special survey carried out in 853 settlements, the result of which was an extremely rich dialectological registry. The material collected does not confirm the traditional view of the disintegration of the Proto-Slavic language, instead showing that the disintegration process of the Slavic whole was much more complex. This is seen in isoglosses that cut Slavic territory into the most highly differing directions. This is proof that particular Slavic groups in various historical periods found themselves in complex relationships amongst themselves and that were constantly changing for economic, political, or cultural reasons. Linguistic material for ALE was collected using a special survey carried out in a majority of European countries, including 15 Croatian survey points. The project also involves the etymological and onomasiological interpretation of linguistic material from all European survey points.This project of linguistic atlases provides world dialectology with organised data on the phonetic, phonological, morphological and lexical systems of a large number of languages and dialects, and enables the well-founded study of the linguistic development of European languages. Croatian material is presented and interpreted, and the linguistic relationships between data from the dialects researched is confirmed. Conclusions are drawn on the history and development of languages, on the relationships between them, and thus on the relationships of the Croatian language towards neighbouring and distant dialects. This will provide material for comparative genetic and typological research of linguistic systems in the Slavic and non-Slavic world. These synchronic and diachronic relationships will be presented in the OLA and ALE books and atlases in the form of maps and commentary.]]></summary_en></project><project>
<id>2641</id><title_hr><![CDATA[Napredni elektromotorni pogoni za primjene u vuči]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3873</user_id><user_firstLast_name>Damir Žarko</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-2238</code><acronim><![CDATA[ELTRAC]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>17824</team_members_id><team_members_names><![CDATA[ Doktorand: Tino Jerčić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[electric traction, electric drives, energy efficiency, optimization, life cycle cost, control of electric drives, power electronics, electric machines]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The development of more efficient transport equipment and reduction of their environmental footprint is in the scope of the energy policy of the EU. The electrification of the transport equipment and the shift of the freight shipments from road to more efficient rail are some of the key elements for the overall increase of energy efficiency in transport and reduction of the greenhouse gas emissions. This project puts emphasis on development of advanced electric drives for traction vehicles for passenger and freight transport running on tracks. Traditional approach to the design of electric drives has an emphasis on components without insufficient insight into the interaction among them and thus it fails to deliver the optimal performance of the overall traction system. The main objective of this project is to enhance the general approach to design of electric drive systems for traction applications by utilizing a synergetic approach to component design accompanied with advanced control algorithms to maximize the system performance and efficiency and minimize the life cycle cost of the vehicle. This objective will be achieved through: (i) development of software tools for computer aided design of electric drive components for traction applications using multiphysics approach with consideration of component interaction with the rest of the system, (ii) development of different traction power converters topologies for evaluation of various modulation and control methods, (iii) development of software environment for dynamic simulation of traction system performance which couples complex nonlinear models of system components with the models of control algorithm and vehicle dynamics, (iv) development of the electric drive control system based on optimal control approach which ensures maximum efficiency of the system during entire drive cycle of the vehicle. The developed algorithms will be experimentally tested on the scaled model of the traction system.]]></summary_en></project><project>
<id>2642</id><title_hr><![CDATA[Animal and robot Societies Self-organise and Integrate by Social Interaction - ASSISI_bf]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5244</user_id><user_firstLast_name>Stjepan Bogdan</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-3174</code><acronim><![CDATA[]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>17856</team_members_id><team_members_names><![CDATA[ Doktorand: Tomislav Haus ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>2643</id><title_hr><![CDATA[Višeagentno modeliranje velikih razmjera za MMORPG mrežne igre ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>891</user_id><user_firstLast_name>Markus Schatten</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-1015</code><acronim><![CDATA[ModelMMORPG]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Informacijske znanosti, </scie_field_hr><scie_field_en>Information sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet organizacije i informatike]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Organization and Informatics]]></institution_en><team_members_id>17828</team_members_id><team_members_names><![CDATA[ Doktorand: Bogdan Okreša Đurić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[large-scale multi-agent systems, agent based modeling, mmorpg, organizational methods, organizational design, artificial intelligence]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Massively multi-player on-line role playing games (MMORPGs) give us the opportunity to study two important aspects of computing: (1) large-scale virtual social interaction of people (players) and (2) the design, development and coordination of large-scale distributed artificial inteligence (AI). A common denominator for both aspects are the methods used to study them: social interaction can be descibed and simulated using agent-based models (ABM social science perspective) whilst distributed AI is commonly modelled in terms of multi-agent systems (MAS computer science perspective). The important question to ask in both perspectives is how do agents organize in order to perform their tasks and reach their objectives? Herein we will employ a combined empirical and theoretical approach towards finding the answer to this question.From the empirical side, we shall study the human behaviour on a number of venues across various gaming servers in order to find most suitable structures, cultures, processes, strategies and dynamics employed by most successful player communities.  From the theoretical side, we shall test a multitude of organizational architectures from organization theory in various MMORPG settings, and compare them with methods found in empirical research.Our research is therefore aimed towards enriching the organizational design methods for the development of MMORPG to foster the development of self-organizing and adaptable networks of large-scale multi-agent systems.With this in mind, our main goals are:1) To identify and formalize adequate organizational design methods for developing LSMAS in MMORPGs.2) To couple them with real-life and future scenarios from industry.3) To provide open and accessible tools, which will allow for design, development, implementation, control, simulation and maintenance of LSMAS in MMORPG.]]></summary_en></project><project>
<id>2644</id><title_hr><![CDATA[Defolijatori kao invazivni šumski štetnici u uvjetima klimatskih promjena ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3209</user_id><user_firstLast_name>Milan Pernek</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-9789</code><acronim><![CDATA[DIFPEST]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Biotehnologija, </scie_field_hr><scie_field_en>Biotechnology, </scie_field_en><institution_hr><![CDATA[Hrvatski šumarski institut]]></institution_hr><institution_en><![CDATA[Croatian Forest Research Institute]]></institution_en><team_members_id>17805</team_members_id><team_members_names><![CDATA[ Doktorand: Ivan Lukić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[invasive forest pests, climate change, biodiversity, insect pathology, Lymantria dispar, Abraxas pantaria,Cydalima perspectalis]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Climate change, particularly extreme weather events, can directly affect forest pests and the damage they cause by influencing the pests’ development, survival, reproduction and spread and by altering host defences and susceptibility. Basic knowledge of the identity, origin, pathway, and time of introduction of invasive species is essential for assessing the threats. Warming is expected to force species to shift their distributions by expanding into new climatic areas. Several projects have shown that genotypes have increasingly migrated to the north in the last decade, mainly caused by climate change. Records of changes as a result of pest-host-climate change interaction, including possible reasons for changes, are a crucial point of forest monitoring which forms the basis for control strategies and forest management decisions. We will build case studies to represent a specific pest-host-climate change interaction model: native and potentially invasive: i) from one isolated population to other population, (Gypsy Moth); ii) from one climate/geographic region to another (Abraxas pantaria) and non-native potentially invasive in a new climate/geographic region (Cydalima perspectalis). The study presents an extensive research on targeted insect pests in Croatia, taking into account the biology of the pest and host plants and all aspects of the bioecology of the species like genetic constitution and origin, thermal requirements, possible host plants, palatability, influence of antagonists etc.) that influence its spread in a novel environment influenced by climate change and possible serious damage. All the gained data could be used for predictive pest risk analysis models for the researched species, as well as for other native and non-native invasive species that could become a serious threat to Croatian forest ecosystems in changed climate conditions in the near future. ]]></summary_en></project><project>
<id>2645</id><title_hr><![CDATA[Aktivacijski receptori NK-stanica specifični za virus i njihovo izbjegavanje od strane virusa]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4958</user_id><user_firstLast_name>Astrid Krmpotić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-6481</code><acronim><![CDATA[ViSpeNKRec]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Medicine]]></institution_en><team_members_id>17754</team_members_id><team_members_names><![CDATA[ Doktorand: Jelena Železnjak ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[NK cells, cytomegalovirus, immunoevasion, Ly49 receptors, KIR receptors, transcriptomics]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The infection of mice with mouse cytomegalovirus (MCMV) as a model of human CMV (HCMV) infection has been particularly informative in elucidating the role of antiviral immune response. NK cells are essential in early control of CMV infection. An evolutionary struggle between NK cells and CMVs can be inferred from a numerous viral mechanisms designed to compromise NK cell function. A deeper insight was gained by studying MCMV evasion of ‘missing-self’ mechanisms and host response to this immunoevasion, illustrated by several MCMV-specific NK cell activating receptors. The work on Ly49H receptor emphasized the selective pressure imposed on the virus to generate variants no longer recognized by this receptor. Another example can be seen from the function of viral m04 protein, which binds to newly synthesized MHC-I molecules and escorts them to the cell surface to engage inhibitory Ly49 receptors. However, while m04 prevents NK cell activation by escaping ‘missing-self’ recognition, several activating Ly49 receptors also depend on its presence for their own recognition of infected cells. Beside m04, another so far unidentified viral factor is required for turning on the activating Ly49 receptors. In addition to characterization of this new viral gene, the aim of this study is to elucidate the functional significance of MCMV-specific activating Ly49 receptors and their interaction with inhibitory counterparts during primary and latent infection.Ly49 receptors in mice are functional homologues of KIR receptors in humans. Recent studies also indicate a strong impact of HCMV on the repertoire and frequency of activating KIR-expressing NK cells, suggesting their specific response to this virus. Therefore, in addition to the MCMV genes involved in ligation of activating Ly49 receptors, here we also propose study aimed to characterize HCMV gene(s) involved in ligation of activating KIRs. We expect these studies to provide new data of groundbreaking potential in the field.]]></summary_en></project><project>
<id>2646</id><title_hr><![CDATA[Music migration in the early modern age: The meeting of the European East, West and South]]></title_hr><title_en><![CDATA[]]></title_en><user_id>7808</user_id><user_firstLast_name>Vjera Katalinić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-5703</code><acronim><![CDATA[]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Znanost o umjetnosti, </scie_field_hr><scie_field_en>Arts, </scie_field_en><institution_hr><![CDATA[Hrvatska akademija znanosti i umjetnosti]]></institution_hr><institution_en><![CDATA[Croatian Academy of Sciences and Arts]]></institution_en><team_members_id>17763</team_members_id><team_members_names><![CDATA[ Doktorand: Maja Milošević ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>2647</id><title_hr><![CDATA[Razvoj i upotreba modela za procjenu potencijala za rast za mala i srednja poduzeća u Hrvatskoj]]></title_hr><title_en><![CDATA[]]></title_en><user_id>2825</user_id><user_firstLast_name>Nataša Šarlija</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-6152</code><acronim><![CDATA[CROSMEGROWTH]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, </scie_field_hr><scie_field_en>Economy, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Ekonomski fakultet u Osijeku]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Economics]]></institution_en><team_members_id>17875</team_members_id><team_members_names><![CDATA[ Doktorand: Ana Bilandžić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[prediction of growth potential, high-growth SMEs, creative industry, policy recommendation for high growth SMEs, access to finance for high-growth SME]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The importance of high-growth enterprises for job creation has been widely substantiated by economic research in recent years. The number and share of high-growth enterprises is relatively small, but the number and share of jobs they create is disproportionally large. The small and medium enterprises with the potential of growth are in the focus of this project. Two overarching goals of this project are:1.	Development of growth potential prediction models for SMEs in CroatiaThe main activities leading up to this goal are: (i) to analyse previous studies relevant for the topic of SMEs&#39; growth potential; (ii) to develop growth potential prediction models for SMEs in Croatia; (iii) to make the models for assessing growth potential available to SMEs to use for purposes of assessing and improving their businesses; (iv) to compare differences in growth potential among SMEs from main industries; (v) to analyse growth potential of SMEs within creative industries and within manufacturing industries.  2.	Providing recommendations to policy makers, recommendation for development of educational programs for SME owners and managers, and recommendations related to sources of finance available to SMEsBased on the research results and models created as part of this project, the main recommendations related to growth potential of SMEs will cover areas of: (i) policy making; (ii) education; and (iii) sources of finance. In recent years policy makers have shown increased interest in fostering fast growing enterprises as they are seen as a key driver of economic growth and employment. Studies conducted in listed companies have showed that two key aspects in supporting high-growth companies are education and access to finance. To allow for comparison of other countries with Croatia, results of this project will be published in relevant scientific journals. To help boost Croatian economy, the results will be presented to all stakeholders interested in this topic.]]></summary_en></project><project>
<id>2648</id><title_hr><![CDATA[Metakognicija kod kategorijalnog učenja, mišljenja i razumijevanja]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4615</user_id><user_firstLast_name>Dražen Domijan</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-2246</code><acronim><![CDATA[METCALTHIC]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Psihologija, </scie_field_hr><scie_field_en>Psychology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Filozofski fakultet u Rijeci]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>6968</team_members_id><team_members_names><![CDATA[ Doktorand: Tanja Gulan ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[metacognition, monitoring, dual processes, category learning, thinking, comprehension]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The fundamental problem of education is how to create a learning environment which will facilitate the acquisition of knowledge and skills. Psychology of education attempts to identify mental processes and mechanisms underlying our ability to learn. Research on self-regulated learning and metacognition is a topic of special importance for educational psychology. Self-regulated learning encompasses cognitive, motivational and behavioral processes which occur while learners undertake activities to accomplish a learning goal. Self-regulation is based on a cyclical process of monitoring and control. The learner monitors the efficiency of the applied learning strategies and responds to feedback obtained from the monitoring process. Metacognition is studied intensively in the areas of memory and text comprehension. The central aim of the project is to explore metacognitive processes of monitoring and control in the domains of: 1. Category learning, 2. Thinking, 3. Grounded (situated) comprehension. All of these domains have been studied extensively but in isolation from metacognition. Our goal is to bring together these disparate fields of study under the same research program. Unifying theme of the project is the distinction between Type 1 and Type 2 processes which can be identified in each domain and whose properties will guide metacognitive judgments. Project team consists of 5 established researchers in the field of experimental psychology and 5 doctoral students whose PhD theses are closely related to the project aims. The project team will utilize newly established Laboratory for experimental psychology equipped with facilities necessary to carry out the proposed project. The project will answer the important question of how accurate are the metacognitive judgments and how effective are the processes of monitoring and regulation in the cognitive domains where metacognition has not been studied in greater detail.]]></summary_en></project><project>
<id>2649</id><title_hr><![CDATA[Social PracticE Cultural Trauma and REestablishing Solid Sovereignties - &#39;&#39;SPECTRESS“ (FP7 - Grant Agreement No. PIRSES-GA-2013-612654)]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5748</user_id><user_firstLast_name>Nebojša Blanuša</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-6078</code><acronim><![CDATA[]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Politologija, </scie_field_hr><scie_field_en>Political Science, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet političkih znanosti]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Political Science]]></institution_en><team_members_id>17769</team_members_id><team_members_names><![CDATA[ Doktorand: Kosta Bovan ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>2650</id><title_hr><![CDATA[Biobanking and Biomolecular Resources Research Infrastructure - Large prospective cohorts]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4228</user_id><user_firstLast_name>Ozren Polašek</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-8445</code><acronim><![CDATA[]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Javno zdravstvo i zdravstvena zaštita, </scie_field_hr><scie_field_en>Public health and health services, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Split School of Medicine]]></institution_en><team_members_id>17833</team_members_id><team_members_names><![CDATA[ Doktorand: Andrea Gelemanović ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>2652</id><title_hr><![CDATA[Proteomski pristup otkrivanju biomarkera ranog oštećenja bubrega i srca u pasa]]></title_hr><title_en><![CDATA[]]></title_en><user_id>801</user_id><user_firstLast_name>Vladimir Mrljak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-5716</code><acronim><![CDATA[BioDog]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Veterinarska medicina, </scie_field_hr><scie_field_en>Veterinary medicine, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Veterinarski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Veterinary Medicine]]></institution_en><team_members_id>17792</team_members_id><team_members_names><![CDATA[ Doktorand: Petra Nižić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[biomarkers, dog, proteomics, kidney, heart, babesiosis, idiopathic dilated cardiomyopathy, chronic valvular disease]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Proteins play essential roles in every cellular process. Biomarkers have the potential to identify key disease indicators at the individualised level, as well as to detect a disease at the early-stages before the development/advance of a serious illness. The emergence of innovative, post-genomic technology, like proteomics, led to the development of strategies aimed at identifying altered, sensitive biomarkers specific to the disease among thousands of molecules present in biological samples. Blood and urine contains multitude, unstudied, and unknown biomarkers, particularly in low-molecular region of blood and urine proteome. Babesiosis, idiopathic dilated cardiomyopathy (iDCM), and chronic valvular disease (CVD-MV) in dogs are common and serious disease. The aims of the project is: to discover novel, early-stage biomarkers of kidney and cardiac disease in dogs which could lead toward more precise and adequate diagnose, prognosis, and monitoring of these diseases; to perform a proteomic analysis on the sera and urine of dogs with uncomplicated and complicated form of babesiosis, as well as dogs with diagnosed iDCM and CVD-MV in order to identify novel, early-stage diagnostic and prognostic biomarkers; to expand the pathway signalling research in order to improve the understanding of pathogenesis for studied disease; to validate new biomarkers for studied diseases.  Tthese expected scientific outcomes will contribute in practice: (a) in a short term view, to detect individualised molecular fingerprints; to improve the diagnosis and prognosis of iDCM, CVD-MV, and babesiosis, as well as potential targets for novel approaches to monitor the therapies of these diseases; to enable the ability to personalise the treatment of individual patients resulting in enhanced patient care; and (b) in a long-term view, to allow entry of proteomics in clinical veterinary medicine in Croatia and transfer of knowledge in –omics- technologies in other parts of veterinary medicine.]]></summary_en></project><project>
<id>2654</id><title_hr><![CDATA[Mehanizam djelovanja gvanilinskih peptida u mozgu]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5255</user_id><user_firstLast_name>Aleksandra Sinđić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-3023</code><acronim><![CDATA[]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>12975</team_members_id><team_members_names><![CDATA[ Doktorand: Nikola Habek ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>2655</id><title_hr><![CDATA[Primjena vakuumskog hlađenja u proizvodnji hrane produljene trajnosti i svježine]]></title_hr><title_en><![CDATA[]]></title_en><user_id>11173</user_id><user_firstLast_name>Mirjana Hruškar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-1031</code><acronim><![CDATA[]]></acronim><duration></duration><status>Prekinut</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Prehrambena tehnologija, </scie_field_hr><scie_field_en>Food technology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Food Technology and Biotechnology]]></institution_en><team_members_id>19135</team_members_id><team_members_names><![CDATA[ Doktorand: Saša Ajredini ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>2656</id><title_hr><![CDATA[Biofizikalni dizajn antimikrobnih peptida i inovativni molekularni deskriptori]]></title_hr><title_en><![CDATA[]]></title_en><user_id>19875</user_id><user_firstLast_name>Jasna Puizina</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-8371</code><acronim><![CDATA[BioAmpMode]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Science]]></institution_en><team_members_id>17844</team_members_id><team_members_names><![CDATA[ Doktorand: Tomislav Rončević ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Antimicrobial peptides, Molecular descriptors, Therapeutic index, Drug development, Design, Data-mining, Antibiotics, Multidrug resistance]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The starting point of this interdisciplinary project is bioinformatic and chemoinformatic data collection connecting molecular structure with physico-chemical and biological properties. In the case of antimicrobial peptides, measured biological activity and therapeutic index data will be collected from published papers with the goal of constructing robust and accurate predictive models. A large amount of data regarding the 20 natural amino acids attributes will also be collected and analysed. We plan to propose new scales of amino-acid attributes that may be a basis for a multitude of future studies. In our experience, construction of good predictive models is not possible without using biophysical insights to propose appropriate molecular descriptors crucial for data-mining procedure and model building. These models should be based on newly developed molecular descriptors. Study of molecular descriptors will be important part of this project, their extremal properties (as indicators of the most active compounds), their complexity of calculation (since exhaustive search for optimal compounds can be computationally demanding) and their interrelationships. Dedicated algorithms for in-silico identification or proposal of structures with the desired properties will be built and verified through synthesis, characterization and testing of predicted antimicrobials. The activity, selectivity, conformation and mechanism of action of lead compounds will be explored using biophysical, biochemical and microbiological techniques. Preliminary investigations by our group of graduate, doctoral and postdoctoral biophysics students has already led to the identification of two designed peptides as being very active against pan-resistant Acetinobacter baumanni, so that initial drug development is within the scope of this project with the aim of finding new classes of non-toxic peptide antibiotics active against multidrug resistant bacteria.]]></summary_en></project><project>
<id>2657</id><title_hr><![CDATA[Razvitak transkriptoma specifičnih populacija neurona u kortikalnim područjima ljudskog mozga bitnim za jezik i sustav zrcalnih neurona]]></title_hr><title_en><![CDATA[]]></title_en><user_id>7740</user_id><user_firstLast_name>Miloš Judaš</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-3663</code><acronim><![CDATA[]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>17841</team_members_id><team_members_names><![CDATA[ Doktorand: Andrija Štajduhar ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>2658</id><title_hr><![CDATA[Višeskalni model betona s identifikacijom parametara]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4072</user_id><user_firstLast_name>Ivica Kožar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-5984</code><acronim><![CDATA[ConcreteMuScID]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Građevinarstvo, </scie_field_hr><scie_field_en>Civil engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Građevinski fakultet u Rijeci]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Civil Engineering]]></institution_en><team_members_id>17853</team_members_id><team_members_names><![CDATA[ Doktorand: Tea Rukavina ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[multi-scale, concrete, system identification, dynamic loading, computer model]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[In complex numerical models the calibration can only be achieved through interaction of measured data with the underlying mathematical model. Especially difficult situation occurs when loading is stochastic (e.g. wind, earthquake, traffic) since there is no direct relation between loading (input) and displacements (output).	System parameter identification will be based on inverse mathematical formulation so to present a reliable and theoretically sound procedure for identification of required parameters. One of the main goals of the system identification procedure is representative volume identification. It will be necessary to consider non-Gaussian stochastic processes with heavy tails characterizing dangerous rare events.	Regarding material parameters this project advocates the hypothesis that the fracture energy of a material is approximately constant and that the material constitutive law should not incorporate “rate effect”. The idea of (approximately) constant fracture energy for all loading rates is new and important in models of concrete under the dynamic loading. Also, the inclusion of the viscous parameter in the existing 3D microplane model for concrete is of vital importance for fatigue analysis since it connects creep and shrinkage (internal material loading) with dynamic loading (external structural loading).	In the end the developed concrete model will account for corrosion by coupling the mechanical properties of concrete and properties affecting the transport of humidity, oxygen and  chloride (chemo-hygro-thermo-mechanical model).	The calibration of the 3D model and its verification will be performed based on the simulation of the corresponding experimental tests from the laboratory and the available literature according to the procedure for system parameter identification described above.	Two main characteristics of the project: highly applicative and at the same time capable of producing high impact scientific results.]]></summary_en></project><project>
<id>2662</id><title_hr><![CDATA[Projekt HRZZ-Uloga ribosomskih proteina L5 i L11 u aktivaciji tumor supresora p53 i patogenezi zloćudnih tumora]]></title_hr><title_en><![CDATA[]]></title_en><user_id>7705</user_id><user_firstLast_name>Siniša Volarević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-3128</code><acronim><![CDATA[]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Medicine]]></institution_en><team_members_id>17834</team_members_id><team_members_names><![CDATA[ Doktorand: Deana Jurada ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>2663</id><title_hr><![CDATA[Procjena ponašanja konstrukcija u graničnim uvjetima rada]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3309</user_id><user_firstLast_name>Goran Turkalj</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-9526</code><acronim><![CDATA[STRUBECON]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Temeljne tehničke znanosti, </scie_field_hr><scie_field_en>Basic engineering sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Tehnički fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Engineering]]></institution_en><team_members_id>17760</team_members_id><team_members_names><![CDATA[ Doktorand: Damjan Banić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[structures, material properties, experimental investigations, numerical investigations, limit state, assessment of structural behaviour]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Structures are designed according to their purpose taking into account all relevant service life requirements, which are usually related to a factor of safety, material properties, service life conditions and of course service life prediction. Structure may be sometimes exposed to unexpected conditions, let say adverse or hazard conditions. These conditions may cause failures making structure incapable to perform the function for which it has been designed. The task is to make an assessment of the structure behaviour at mentioned conditions and decide if the structure is capable for further operation. This means the assessment should provide an answer if the structure has sustained irreparable damage. Therefore, the main objective is to provide an assessment of structure behaviour, by comparing of the parameters like stress, strain, crack occurring, etc., caused by certain load level and temperature at this unexpected limit state with those allowed by material properties. To assess structural behaviour in operation at limit state, the following research sub-objectives should be accomplished: testing of material properties for the different environmental conditions; definition of impact energy as well as the determination of the crack driving force and life assessment of structural elements; evaluation of the semi-rigid structural joints/connections behaviour; development of a numerical algorithm for optimization of semi-rigid framed structures; creep buckling simulations of composite beam-type structures; proper constitutive modelling at limit operating conditions (i.e. plasticity, damage, thermomechanical coupling); application of new materials to be used at limit state – nanocomposites. Targeted structures are single and multi storey steel buildings, rigs, high-power electrical transmission towers, ship structures, etc.]]></summary_en></project><project>
<id>2665</id><title_hr><![CDATA[Bioindikatori vodenih masa u Jadranu]]></title_hr><title_en><![CDATA[]]></title_en><user_id>2829</user_id><user_firstLast_name>Zrinka Ljubešić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-5886</code><acronim><![CDATA[BIOTA]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>17842</team_members_id><team_members_names><![CDATA[ Doktorand: Maja Mejdandžić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Adriatic Sea, climate changes, water mass tracers, cyanobacteria, coccolithophorids]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Interannual changes in the circulation patterns and water mass dynamics highly influence biogeochemical processes in the Adriatic Sea, consequently impacting the functioning of the Adriatic ecosystem. Specific phytoplankton ecological preferences drive their temporal and spatial distribution, reflecting their dependence on specific temperature ranges, light levels, nutrient availability and other environmental gradients. Hence, some phytoplankton taxa can be used as water mass tracers (biotracers). We hypothesize that picophytoplanktonic prokaryote Prochlorococcus and nanophytoplanktonic eukaryotes coccolithophores: Emiliania huxleyi and/or Gephyrocapsa oceanic are such organisms, and can be used for tracing water masses in the Adriatic. Here, we propose interdisciplinary study where oceanography, taxonomy of phytoplankton and molecular recognition are combined to detect and follow water masses. Two winter cruises in the southern Adriatic will be conducted with station positions and sampling depths defined in situ. Water mass detection will be based on pre-defined physical characteristics; however, we also plan to use optical measurements in conjunction with the proposed sampling to develop an optical based criterion for definition of the targeted water masses. Phytoplankton community will be assessed using multiple tools to confirm the presence and to determine distribution, abundance and diversity of the proposed biotracers in sampled water masses. With the variability and trends of the Adriatic circulation as well as the water mass characteristics brought on by changing climate, we believe that proposed study is timely and needed as it is offering a holistic and integrated approach to oceanography of the Adriatic. Most importantly, this study is proposing to develop a new set of interdisciplinary tools that will be essential for future research activities.]]></summary_en></project><project>
<id>2666</id><title_hr><![CDATA[MAtematička analiza multifizikalnih problema koji uključuju tanke i kompozitne strukture i fluide]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5074</user_id><user_firstLast_name>Boris Muha</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-4384</code><acronim><![CDATA[MAMPITCoStruFl]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>17761</team_members_id><team_members_names><![CDATA[ Doktorand: Marija Galić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[thin structures, composite structures, dimensional reduction, homogenization, Gamma convergence, fluid-structure interaction, existence of solution ]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Composite materials are materials made from two or more constituent materials with different physical properties that, when combined, produce a material with characteristics different from those of its individual components. Thin and composite structures are of extreme importance for applications in engineering (e.g. building blocks, boats, ships, aircraft design) and biology (bones, biological tissues, blood vessels) where they are often subjected to fluid load. The analysis of these kind of complex multi-physics systems is very challenging from the mathematical point of view. Namely, the analysis of thin and composite structures and fluids includes the analysis of nonlinear partial differential equations (nonlinear PDEs), which leads to interesting mathematical questions (Gamma limits of a certain system of nonlinear equations with highly oscillating coefficients, existence for a certain system of nonlinear PDEs). This project plans the following: derivation of lower dimensional models in elasticity for highly oscillating materials, optimal design problems, derivation and analysis of fluid-structure interaction problems (derivation of coupling conditions, well-posedness and asymptotic stability analysis). We will use both Calculus of Variation and PDEs techniques to approach different topics, using the benefits from both. We strongly believe that this diversity will bring additional value to Croatian applied mathematics and will provide young people to develop and get acquainted with different approaches of the modern applied mathematics.]]></summary_en></project><project>
<id>2667</id><title_hr><![CDATA[Utjecaj okolišnog stresa na pojavnost i međudjelovanje biološki važnih organskih molekula i mikronutrijenata u morskom ekosustavu]]></title_hr><title_en><![CDATA[]]></title_en><user_id>81</user_id><user_firstLast_name>Blaženka Gašparović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-3224</code><acronim><![CDATA[AMBIOMERES]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>17849</team_members_id><team_members_names><![CDATA[ Doktorand: Tihana Sesar ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[organic matter, lipids, acidic polysaccharides, micronutrient metals, oligotrophy, eutrophy, monocultures, field work]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Recently documented oligotrophication of the Adriatic Sea caused by global changes opened questions how this reflects on the quality and quantity of organic matter (OM) produced by the phytoplankton and on the consequent influence on the micronutrient metals availability and cycling. Within the project, a progressive (model and in-situ) approach will be accomplished to reveal crucial alterations in the marine ecosystem. Initial investigations will imply model experiments on the interaction of selected OM (polysaccharides, lipids, polymeric organic matter containing N catalytic atoms) with micronutrient metals (Fe, Co, Cu, Zn and Cd). Additionally, phytoplankton monoculture incubation under various growth conditions (nutrient concentrations and temperature variations) will be included in order to comprehend multiple impacts on the phytoplankton OM production and micronutrients metals distribution. Model experiments will be followed by in-situ investigations at the selected oligotrophic and eutrophic areas of the Adriatic Sea. This will give holistic informations on the natural marine biochemical cycles and linkage between OM and micronutrient metals. In-situ investigations will be focused on the seasonal variations of the OM and micronutrient appearance and concentrations in combination with physico-chemical parameters (temperature, salinity, pH, O2), and dissolved and particulate organic carbon content, surface-active organic substances and macronutrients (PO4, NO3, NO2, NH4). These investigations will be assessed by intercomparable and multimethodological approaches using various chromatographic to electrochemical techniques. Finally, taking into account all obtained results an important part of the natural marine ecosystem processes will be characterized in the prospective of climate changes.]]></summary_en></project><project>
<id>2668</id><title_hr><![CDATA[Genetski mehanizmi lizosomalne disfunkcije u Parkinsonovoj bolesti]]></title_hr><title_en><![CDATA[]]></title_en><user_id>2684</user_id><user_firstLast_name>Fran Borovečki</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-9688</code><acronim><![CDATA[LYSOGENE PD]]></acronim><duration></duration><status>Prekinut</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>19042</team_members_id><team_members_names><![CDATA[ Doktorand: Antonela Blažeković ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Parkinson&#39;s Disease, alpha synuclein, next-generation sequencing, lysosomal dysfunction, iPSC]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Accumulation of misfolded proteins in the brain represents a pathological hallmark of neurodegenerative diseases, suggesting that inadequate clearance of aggregation-prone proteins plays an important role in the disease pathogenesis. The synucleinopathies, including Parkinson’s disease (PD) and dementia with Lewy bodies (LBD), are a group of neurodegenerative disorders characterized by the accumulation and aggregation of a-synuclein (aSyn). Studies on the rare inherited forms of PD caused by mutations in the aSyn gene have highlighted disturbed aSyn clearance through the autophagy-lysosomal pathway (ALP) as a key mechanism leading to PD/LBD. Furthermore, several rare inherited disorders caused by mutations in the lysosomal genes show parkinsonian-like phenotype and accumulation of aSyn, providing additional evidence for the role of lysosomal dysfunction in the pathogenesis of synucleinopathies. The goal of the project is to elucidate the involvement of lysosomal gene mutations and lysosomal dysfunction in the ethiology of PD/LBD. Using the next-generation sequencing and Haloplex-based protocol we will design LYSOGENE platform to anayze genetic mutations/variations in the ALP genes that may lead to and predispose to PD/LBD. The identified ALP mutations will be further characterized in vitro in human neuronal cell lines using the knockdown and overexpression approaches. In particular, we will monitor how the identified mutations affect ALP function, accumulation and aggregation of aSyn, as well as neurotoxicity. Finally, we will validate our mechanistic findings in a biologically relevant model of human dopaminergic neurons derived from the PD/LBD patient’s fibroblasts using the induced pluripotent stem cell technology. Through these studies we will identify genetic variations/mutations in the ALP genes that cause or contribute to PD/LBD. The results of the project may help to identify potential new therapeutic targets for development of neuroprotective treatments.]]></summary_en></project><project>
<id>2669</id><title_hr><![CDATA[Kodovi i s njima povezane kombinatoričke strukture]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5935</user_id><user_firstLast_name>Vedran Krčadinac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-5387</code><acronim><![CDATA[CoCoS]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>17780</team_members_id><team_members_names><![CDATA[ Doktorand: Renata Vlahović ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[code, network coding, t-design, q-ary design, graph, strongly regular graph, finite group]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The project will deal with construction of codes and combinatorial structures, such as combinatorial designs, designs over finite fields (q-ary designs), difference sets and various types of graphs, for example strongly regular graphs and divisible design graphs. Beside linear codes over finite fields and finite rings, we will also investigate quantum codes and network codes. In fact, the links and connections between codes and combinatorial structures are the main focus and emphasis of the proposed project. For constructions of the combinatorial structures and codes we will mainly use algebraic, geometric and enumerative techniques, as well as computational methods. When dealing with combinatorial structures, these include in particular constructions from finite groups and constructions using orbit matrices. The very general Kramer-Mesner method will be implemented and combined with other methods like that of tactical decompositions. Codes will be constructed directly from the obtained combinatorial structures, and vice versa. Our research in scope of this project will also include constructions of Hadamard matrices and related designs and codes. All gotten structures will be analyzed in terms of their automorphism groups and other structural (geometric, algebraic) properties. Obtained codes, designs and graphs will be compared with the previously known structures. As a result of the proposed research, we expect constructions of codes with good properties, possibly better than the presently known codes, and constructions and classifications of various combinatorial structures.]]></summary_en></project><project>
<id>2671</id><title_hr><![CDATA[Automorfne forme, reprezentacije i primjene]]></title_hr><title_en><![CDATA[]]></title_en><user_id>820</user_id><user_firstLast_name>Goran Muić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-1470</code><acronim><![CDATA[Automorphic forms]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>17779</team_members_id><team_members_names><![CDATA[ Doktorand: Sonja Žunar ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[automorphic forms, representations, Eisenstein series, cuspidal forms, theta correspondence]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Recent and major breakthrough in the Langlands programme is a proof of existence endoscopic transfer of representations both local and global automorphic from split classical groups to GL(n) proved mainly by Arthur. Our research proposal  fits very well with this recent development. First of all, the work of Arthur has its local application in  the classification of representations of discrete series that was done by Moeglin and Tadić. Based on those results we plan to pursue the following investigations in the representation theory of p-adic groups.  We would like to compute the Jacquet modules of discrete series representations completely.This will help us understand representations parabolically induced from those discrete series (generalized principal series) completely. This will have consequence on the problems of determination of complementary series for classical groups a problem related to the classification of unitary representations. Results of Gan, Savin and Ichino will help us extend some of those results to metaplectic groups. This will have important consequence on the determination of theta correspondence for dual pairs consisting of odd orthogonal and metaplectic groups such as explicit determination of all theta lifts. In the theory of automorphic forms, we would like to understand the construction of Arthur and Moeglin more explicitly. This will construct new series of square integrable representations; some special cases were obtained earlier by Muić, and Muić and Hanzer.This will give locally many interesting unitary representations which are more complicated than that has appeared in earlier works of Speh, Rogawski, Tadić, Muić, Savin, and Hanzer. We will apply those methods to study cohomology and poles of automorphic L-functions. ]]></summary_en></project><project>
<id>2672</id><title_hr><![CDATA[Razvoj paketa računalskih programa za naprednu analizu štitova od gama i neutronskog zračenja]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6070</user_id><user_firstLast_name>Krešimir Trontl</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-6107</code><acronim><![CDATA[DOCPAGANSA]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>17764</team_members_id><team_members_names><![CDATA[ Doktorand: Paulina Dučkić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[machine learning, active learning, parallel and distributed computing, gamma shielding, neutron shielding]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Radiological safety analysis is equally important in all fields of peaceful application of nuclear energy, like industry or medicine, as well as for adequate radioactive waste management. In general, shielding analyses can be classified into two categories: preliminary analyses and final analyses. Preliminary analysis can be conducted using computer codes based on engineering methods, the most used one based on point-kernel method. Recent research indicated that a new approach can be used in determination of buildup factors as the key parameters of point-kernel method. The approach is based on machine learning technique, namely Support Vector Regression (SVR). For efficient training of the SVR models of a complex physical problem, an active learning procedure has to be defined. Final shielding analysis is usually conducted by computer codes based on either deterministic or statistic methods placing high time and hardware demands, but resulting in more accurate results. Advanced numerical procedures utilize advantages of both, deterministic approach as well as stochastic approach resulting in a hybrid deterministic-stochastic procedure increasing the efficiency of the overall analysis.The overall objective of the proposed project is the development of the synthesized calculational tool to enable all stages of a shield design to be performed within integrated environment. To accomplish this objective following activities are planned: definition of the optimal active learning procedure in regression framework to prepare data sets for SVR model creation, investigation of gamma and neutron buildup factors and preparation of SVR models, development of the computational tool for preliminary stage shielding design, optimization of hybrid deterministic-stochastic numerical procedure, development of the control module for automatic shielding analyses process control, preparation of front-end and back-end interface, testing of the final shielding analysis environment. ]]></summary_en></project><project>
<id>2675</id><title_hr><![CDATA[Pouzdanost konstrukcije oštećenog naftnog tankera u Jadranskom moru]]></title_hr><title_en><![CDATA[]]></title_en><user_id>810</user_id><user_firstLast_name>Joško Parunov</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-5833</code><acronim><![CDATA[DATAS]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Brodogradnja, </scie_field_hr><scie_field_en>Naval architecture, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>17787</team_members_id><team_members_names><![CDATA[ Doktorand: Ivana Gledić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[oil tanker, Adriatic sea, damaged ship, structural reliability, risk assessment]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The aim of the project is to propose methodology of structural safety assessment of the damaged oil tanker in the Adriatic Sea and to set-up procedure for rational decision making of ship in the situations requiring emergency response actions. This can also be used to develop more rational rules and regulations related to the traffic of large ships operating in the Adriatic and to investigate possibilities of a ship structural design improvement with respect to the most dangerous incident types. Despite advancements in navigation systems, ship accidents continue to occur, the most recent one being the grounding of a cruise ship Costa Concordia. These accidents have resulted in the loss of cargo, pollution of environment, and most unfavorable the loss of life. Accidental damages of ships can occur in any number of ways. The two cases which exhibit most concerns are the collision between ships and hard grounding on seabed. When a ship is damaged, the operators need to decide on immediate repair actions by evaluating the effects of the damage on safety of the ship by considering simultaneously effects of the damage in the hull girder ultimate bending moment and in the applied loads (wave and still-water induced bending moments). In general, as the consequence of an accident still water loads on ship will considerably increase, while the ship strength will decrease. Disaster of the tanker Prestige in 2002 clearly showed that the ship in damaged condition can be broken due to the above mentioned phenomenon and sink as the most unfavorable outcome of such an accident with likely spillage of a large amount of pollutant oil on board.Since the Adriatic is an enclosed sea basin, with the low level of the activity of the sea waves and current, an accident of the oil tanker with significant oil spill would make irreversible ecological disaster with enormous economic losses. Therefore, safety of oil transportation in the Adriatic is a major concern of the whole society.]]></summary_en></project><project>
<id>2676</id><title_hr><![CDATA[MULTIPLEX— Foundational Research on MULTIlevel comPLEX networks and systems, project number 317532]]></title_hr><title_en><![CDATA[]]></title_en><user_id>11143</user_id><user_firstLast_name>Vinko Zlatić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-5324</code><acronim><![CDATA[]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>17748</team_members_id><team_members_names><![CDATA[ Doktorand: Andrea Kadović ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>2677</id><title_hr><![CDATA[Dynamic Management of Physically Coupled Systems of Systems (DYMASOS)]]></title_hr><title_en><![CDATA[]]></title_en><user_id>7618</user_id><user_firstLast_name>Mato Baotić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-6214</code><acronim><![CDATA[]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Temeljne tehničke znanosti, </scie_field_hr><scie_field_en>Basic engineering sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>17870</team_members_id><team_members_names><![CDATA[ Doktorand: Branimir Novoselnik ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>2678</id><title_hr><![CDATA[Preobrazba građanskog pravosuđa pod utjecajem globalnih i regionalnih integracijskih procesa. Jedinstvo i različitost / Transformation of Civil Justice under the Influence of Global and Regional Integration Processes. Unity and Diversity]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3028</user_id><user_firstLast_name>Alan  Uzelac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-2989</code><acronim><![CDATA[]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Pravo, </scie_field_hr><scie_field_en>Law, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Pravni fakultet u Zagrebu]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Law]]></institution_en><team_members_id>17777</team_members_id><team_members_names><![CDATA[ Doktorand: Juraj Brozović ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>2679</id><title_hr><![CDATA[Otkrivanje novih proteinskih interakcija kao podloga za nove pristupe liječenju melanoma čovjeka]]></title_hr><title_en><![CDATA[]]></title_en><user_id>649</user_id><user_firstLast_name>Neda Slade</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-1853</code><acronim><![CDATA[ProNetMel]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>17835</team_members_id><team_members_names><![CDATA[ Doktorand: Nikolina Hanžić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[melanoma, protein interactions, p53, p73, nm23, Gli]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Metastatic melanoma represents a major clinical problem due to rising incidence and resistance to available therapies. Therefore, there is a necessity for developing novel molecular approaches to treat this disease. Unlike other tumors, in melanoma p53 is relatively rarely mutated. However, overexpressed p53 fails to function as a tumor suppressor and tumor cells continue to proliferate and spread. This suggests that regulation of p53 activity depends on the interplay between p53 and its binding partners. Based on current state of knowledge, we hypothesize that p53 function in malignant melanoma might be altered through the interactions with p53 small molecular weight and p73 isoforms, nm23/NDPK and Gli families of proteins. Thus we will search for p53 protein binding partners in melanoma. The interactions identified by mass spectrometry will be further confirmed using microarray-based approaches and co-immunoprecipitation techniques. Furthermore, the expression profile of genes/proteins of interest in panel of melanoma cell lines and melanoma tissue samples will be investigated. The potential impact of the identified p53 interacting partners on its transcriptional activity and the stimulation of apoptosis will be determined. The depletion of partners using siRNA technology would confirm the involvement of selected proteins on p53 activity. The subcellular localization of the proteins in complex will be revealed by advanced fluorescent microscopy methods on state-of-the-art instrumentation what would give us the insight on dynamics of their interactions. The proposed research could provide a possible explanation why p53 function in melanoma is abrogated. The aim of this project is to determine the complexity of p53 interactions and their role in the onset and progression of human melanoma and offer new, innovative solutions in diagnosis, prognosis and therapy.]]></summary_en></project><project>
<id>2680</id><title_hr><![CDATA[PONOVNA UPORABA MULJA S UREĐAJA ZA PROČIŠĆAVANJE OTPADNIH VODA U BETONSKOJ INDUSTRIJI - od mikrostrukture do inovativnih proizvoda]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5991</user_id><user_firstLast_name>Dražen Vouk</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-6363</code><acronim><![CDATA[RESCUE]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Građevinarstvo, </scie_field_hr><scie_field_en>Civil engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Građevinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Civil Engineering]]></institution_en><team_members_id>17785</team_members_id><team_members_names><![CDATA[ Doktorand: Domagoj Nakić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Wastewater treatment, Sewage sludge, ISSA, Concrete, Microstructure, Sustainable materials]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[In the wastewater treatment process, a by-product is generated, as additional waste called sewage sludge (0.5 kg of sludge per 1 m3 of wastewater). Adequate wastewater management implies collection and treatment of wastewater, but also adequate management of waste substances generated in the treatment process. Joining the European Union Croatia has made the commitment to construct all treatment plants of capacities over 10.000 PE by 2018. This will result in putting into operation of treatment plants with the total load of about 4.000.000 PE (250.000.000 m3 of wastewater), which will generate about 215.000 tons per year of raw sewage sludge and after incineration around 49.000 tons per year of incinerated sewer sludge ash (ISSA). Taking into account that EU Directives are limiting the amount of sewage sludge waste to be landfilled, and Waste Framework Directive (2008/98/EC) puts reuse and recycling of waste into the most favorable position, it is evident that enormous amount of ISSA will become available for appropriate management.The composition of the generated sewage sludge and ISSA is dependent on the technology of wastewater and sludge treatment. Reviewing the available knowledge in this field leads to the conclusion that the influence of the method of incineration on physical properties of ISSA and the technology of preparing and processing of concrete and concrete elements has not been fully analysed. The main objective of the project is to investigate the possibilities of recycling the sludge from WWTPs in preparing of new innovative products in concrete industry. Based on comprehensive experimental research and multidisciplinary knowledge of the partners (hydrotecnical, materials and chemical engineering), a strategy will be proposed for the comprehensive and sustainable management of ISSA and its transformation from unwanted waste material into valuable resource for production of construction products with ecological, economical and technological benefits.]]></summary_en></project><project>
<id>2681</id><title_hr><![CDATA[Razvoj in vitro/ex vivo modela za ispitivanje permeabilnosti novih topičkih oftalmičkih lijekova]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4075</user_id><user_firstLast_name>Jasmina Lovrić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-5517</code><acronim><![CDATA[]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Farmacija, </scie_field_hr><scie_field_en>Pharmaceutical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Farmaceutsko-biokemijski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Pharmacy and Biochemistry]]></institution_en><team_members_id>17861</team_members_id><team_members_names><![CDATA[ Doktorand: Bisera Jurišić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>2682</id><title_hr><![CDATA[Dalmacija kao odredište europskog Grand Toura u 18. i 19. stoljeću]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4910</user_id><user_firstLast_name>Irena Kraševac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-6881</code><acronim><![CDATA[GRANDTOURDALMATIA]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Povijest umjetnosti, </scie_field_hr><scie_field_en>Art history, </scie_field_en><institution_hr><![CDATA[Institut za povijest umjetnosti]]></institution_hr><institution_en><![CDATA[Institute of Art History, Zagreb]]></institution_en><team_members_id>5083</team_members_id><team_members_names><![CDATA[ Doktorand: Iva Raič Stojanović ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Grand Tour, Dalmatia, Neoclassicism and Romanticism, Representation of Place, Contemporary Urbanscape]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Grand Tour – an exceptional journey which reached its peak in the 18th C, thoroughly changed human perception of nature and society. From the 18 to the 19th C the revolution in natural, human and technical sciences marks the beginning of modern society and contemporary approach in arts and architecture.Although Grand Tour originally focused on Rome, the exploration of  the Ancient World as the origin of Neolassicism widened its travelling radius onto further parts of the Roman Empire, among which Dalmatia held a prominent position. Drawings and literary works by travel artists and writers from that period are treasured in prestigious European museums and libraries and together constitute a priceless  portion of European cultural heritage.For the first time, all known travelogues and drawings about Dalmatia from that period will be collected, analysed and evaluated in terms of literary theory and theory of architecture. The overall aim of the project is to identify, problematise and integrate the issues related to the phenomenon of recording the space, predominantly in Dalmatia. The specific goals of the project are: establishing a working group of young researchers; raising issues of international relevance related to description of Dalmatian space based on works of the 18th and  19th C artists and writers; advancing the development of research methodology; making applicable the research of contemporary cultural-spatial context for critical rethinking in contemporary approach to architecture; creating a platform for further research at international level; establishing a dissemination channel towards both European scientific circles and wider audience.In three years of research the following will be realised: the research of archival records; field research; project webpage; three international workshops; international scientific  conference; public lectures; scientific papers and on-line proceeding book of workshops and conference.]]></summary_en></project><project>
<id>2683</id><title_hr><![CDATA[Inovativno pametno poduzeće]]></title_hr><title_en><![CDATA[]]></title_en><user_id>2921</user_id><user_firstLast_name>Ivica Veža</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-2672</code><acronim><![CDATA[INSENT]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, </scie_field_hr><scie_field_en>Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Fakultet elektrotehnike, strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Electrical Engineering, Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>17852</team_members_id><team_members_names><![CDATA[ Doktorand: Ivan Peko ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[innovation, smart enterprise, learning factory, production systems, business model]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The introduction of the Internet of Things and Services into the manufacturing environment is ushering in a fourth industrial revolution: Industry 4.0. This new type of industry is based on Smart Factory model or Smart Enterprise. The main features of Smart Enterprise can be summarized into the following: smart personalized product, product and service provider, and high level of collaboration.Manufacturing is today, as it always has been, a cornerstone of the economy of developed nations. An important advantage of manufacturing is that it calls on the skills of everyone from entry-level factory workers to scientists, engineers, and business professionals. Hence, main focus of this project will be Manufacturing Enterprises. Vision of Innovative Smart Enterprise for next generation manufacturing can be summarized into following features: Lean, Flexible, Agile, Efficient, Responsive, Information Enabled, Predictive, and Safe. All these features result with long term sustainability.The main objective of this project is to develop Croatian model of Innovative Smart Enterprise (HR-ISE model). Hence, a profound research will be performed to describe current state of Croatian manufacturing enterprise. It will be the answer on the question: “Where are we?”Furthermore, a synthesis of analysis of Croatian manufacturing enterprises will be done through development of HR-ISE model. It will be the answer on the question: “Where we want to be?”Finally, a special learning environment will be established: Learning Factory. It will be a place in which transfer of developed HR-ISE model to the economy subjects will be achieved. It will be the answer on the question: “How can we get there?”Results of this project will be of the highest value for “fallen” Croatian industry. The development of HR-ISE model and its transfer to economy can have strong impact on recovery of Croatian industry, and it can significantly improve competencies and capabilities of Croatian enterprises.]]></summary_en></project><project>
<id>2685</id><title_hr><![CDATA[3D sustav za mjerenje oblika trupa tijela]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6456</user_id><user_firstLast_name>Tomislav Pribanić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-8227</code><acronim><![CDATA[3DHumanTorso]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>17809</team_members_id><team_members_names><![CDATA[ Doktorand: Matea Đonlić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[3D reconstruction, structured light, passive stereo, scoliosis, degenerative disease, 3D  spine shape]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The aim of this work is to develop a low-cost automated system to measure the three- dimensional shape of the back and front of the human torso. It will enable numerous physicians to acquire the trunk surface (TS). TS symmetry is one of the key elements in diagnostic and evaluation of various treatments in patients with trunk deformities. Common radiographic evaluation methods are known to expose patients to a radiation and, besides, radiography is actually 2D representation of 3D problem which has been shown not to be directly related to the shape of the back. Thus, there has been a constant motivation among researchers at (inter)national level to develop an optimal methodology for 3D reconstruction of the back. Still, most of those developed systems are mainly directed to 3D reconstruction of the spine and calculation of the Cobb angle which is still regarded by many as the gold standard method to measure scoliotic deformity. Still, the Cobb angle alone cannot explain the whole of the surface deformity. Evidently, there is high need to investigate development of a 3D reconstruction system which will capture both back and front of the patient, i.e. the entire trunk surface. In turn it would enable a more thorough analysis of the patient’s deformity pattern, i.e. a second major goal during this project is to derive other parameters (not only Cobb angle) in order to quantify trunk deformities. In designing 3D system we underline that we plan to research the implementation of both passive and active stereovision strategies. Researching the implementation of combined best features from passive and active stereo for one concrete of 3D system aimed at TS reconstruction (scoliosis), would be a great contribution for potential other 3D applications. Degenerative diseases of spine represent a serious social problem in Croatia. More than 10% of population has frequent problems with it. Clearly, every research contribution for this matter would be an extremely valuable asset.]]></summary_en></project><project>
<id>2686</id><title_hr><![CDATA[Starosno-ovisna ekspresija membranskih prijenosnika u štakora]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1396</user_id><user_firstLast_name>Ivica Rubelj</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-6992</code><acronim><![CDATA[AGEMETAR]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>19039</team_members_id><team_members_names><![CDATA[ Doktorand: Lucia Nanić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[aging, antioxidants, drug transporters, hepatotoxicity, liver, kidney, Klotho, membrane transporters, nephrotoxicity, oxidative stress,  telomeres ]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Aging is a physiological process characterized by a gradual decline in physical fitness and other functional capabilities. The mechanisms of aging and possible actions of slowing down or ameliorating aging-related processes are poorly understood. In humans, one of the characteristics of old age is polypharmacy, which elevates risks of drug-drug interactions and drug-induced adverse reactions and organ toxicity, such as hepatotoxicity and nephrotoxicity. These reactions may partially result from diminished drug metabolism and/or mainly from impaired activity/expression of various membrane transporters that are responsible for drug excretion in liver and kidneys. These both mechanisms have been poorly studied in senescent organs. Here we promote a hypothesis that the aging-induced oxidative stress, known to downregulate the activity/expression of the aging suppressor gene (Klotho) and to shorten the length of telomeres, also diminishes the activity/expression of various membrane transporters in liver and kidneys, and that these changes can be ameliorated by treating animals with antioxidants resveratrol and melatonin. The extent and the intensity of aging-related changes, and the beneficial effects of antioxidants may be sex-related. To test this hypothesis, we propose various biochemical and cell- and molecular-biological studies of aging parameters and aging-dependent expression of various membrane transporters in the mammalian liver and kidneys using a rat model of experimental aging. Possible aging-related decline in the expression of these transporters may explain a higher incidence (women > man) of drug interactions and toxicity in old people. The studies will define the underlying cellular mechanisms that contribute to generation of the aging-related pathophysiological conditions in the liver and kidneys, and will indicate possible ways of their amelioration. Positive results may point to remedies to be used for improving the health of elderly people.]]></summary_en></project><project>
<id>2687</id><title_hr><![CDATA[Methods for high-throughput glycoproteomic analysis“ (HTP GlycoMet)]]></title_hr><title_en><![CDATA[]]></title_en><user_id>7807</user_id><user_firstLast_name>Djuro  Josic</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-1373</code><acronim><![CDATA[]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Biotehnologija, </scie_field_hr><scie_field_en>Biotechnology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Fakultet biotehnologije i razvoja lijekova]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Biotechnology and Drug Development]]></institution_en><team_members_id>12865</team_members_id><team_members_names><![CDATA[ Doktorand: Tamara Martinović ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>2688</id><title_hr><![CDATA[Upravljanje povjerenjem i koordinacija interakcija u pametnim mrežama ljudi, strojeva i organizacija]]></title_hr><title_en><![CDATA[]]></title_en><user_id>2612</user_id><user_firstLast_name>Gordan Ježić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-1586</code><acronim><![CDATA[SmartPMONetworks]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>25471</team_members_id><team_members_names><![CDATA[ Doktorand: Matea Žilak ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[social networks, machine-to-machine communication, networked organizations, networked society, trust, coordination, context-awareness, big data]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[We live in a networked society where everything is connected. By 2020 there will be 8 billion people and 50 billion machines in the world and almost all of them will be connected through some kind of network. Furthermore, people and machines that share a certain collective goal will be grouped into some kind of organization, which again will be connected with other organizations and/or people/machines. In order to maintain sustainability of the networked society we need a framework and algorithms which will enable us to i) manage trust; and ii) coordinate interactions in such a complex eco-system consisting of thousands, millions or even billions of interconnected entities. Both the framework and algorithms should be scalable and robust (from the perspective of a network size and heterogeneity), support real-time dynamics (from the perspective of network interactions) as well as be applicable and analyzable at different levels of granularity (at a micro, mezzo and macro network levels). A possible solution for the framework is the “Smart Network”, where people/machines/organizations are represented as nodes which are described by profiles and build a network of connections. The “smartness” of “Smart Networks” stems from profiling nodes and realizing connections using automated computational methods, what is enabled by latest enhancements in information systems and state-of-the-art solutions in communication technologies. The “Smart Network” framework enables design of scalable, robust and real-time algorithms for managing trust and coordinating interactions because it can be i) formally operationalized as a graph where edges represent nodes and vertices represent connections; ii) functionally modeled as a multi-agent system where agents embody edges and relationships embody vertices; and iii) analyzed through complexity theory where sustainable solutions emerge as a result of a bottom-up modeling principle.]]></summary_en></project><project>
<id>2690</id><title_hr><![CDATA[Karakterizacija reakcije osteoklastnih progenitora na artritis]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3075</user_id><user_firstLast_name>Danka Grčević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-8382</code><acronim><![CDATA[COPERA]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>17836</team_members_id><team_members_names><![CDATA[ Doktorand: Darja Flegar ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[osteoclasts, arthritis, inflammation, progenitors, differentiation, cytokines, chemokines]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Chronic joint diseases affect more than a third of the world’s population and represent a major health problem. Several forms are classified in clinical practice, depending on the main pathogenic mechanism: osteoarthritis, rheumatoid arthritis (RA) and spondyloarthritis Collagen-induced arthritis (CIA) is a widely used mouse model of RA and is still an indispensible tool to study the disease pathogenesis. Through the production of osteoresorptive mediators by immune cells, chronic inflammation in arthritis creates a microenvironment that promotes osteoresorption by osteoclasts (OC). OCs are multinucleated bone-resorbing cells arising from myeloid hematopoietic lineage. A number of systemic and local stimuli, such as hormones and cytokines/chemokines, promote osteoclastogenesis by enhancing OC differentiation, migration, activation, lifespan and function, but the exact mechanisms of how the inflammatory network works in vivo in the context of arthritis are largely unclear. Particularly, the human osteoclast progenitor (OCP) populations are not precisely defined and it is, as yet, unknown which critical mediators have the potential to activate OCPs and attract them to produce joint lesions. Using the mouse model of CIA and samples from arthritic patients we propose to elucidate differentiation sequence of early progenitors into mature OCs, shifts in the frequency of discrete OCP subpopulations and their migration patterns during arthritis. We plan to identify distinct OCP subpopulations in the bone marrow, periphery and joint lesions, their migratory and homing patterns, and their functional links to bone loss in arthritis. We expect to define the properties of inflammatory microenvironment in the regulation of OC trafficking, differentiation and activity in arthritis. A better characterization of arthritis-induced OCP subpopulations could offer the potential to design therapeutic approaches to control their migration and curtail their osteoresorptive potential.]]></summary_en></project><project>
<id>2691</id><title_hr><![CDATA[Europski FP7 projekt „GlowBrain - Primjena matičnih stanica i biomaterijala u oporavku mozga - unapređivanje mogućnosti postojećeg istraživanja mozga kroz inovativno in vivo molekularno oslikavanje“ ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>11180</user_id><user_firstLast_name>Marija Ćurlin</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-8752</code><acronim><![CDATA[]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>19179</team_members_id><team_members_names><![CDATA[ Doktorand: Marta Skelin ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>2692</id><title_hr><![CDATA[Utvrđivanje sastava crijevne mikrobiote, upalnih markera, prehrambenog i endokrinog statusa u pacijenata s upalnom bolesti crijeva]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5552</user_id><user_firstLast_name>Donatella Verbanac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-6863</code><acronim><![CDATA[MINUTE for IBD]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>13628</team_members_id><team_members_names><![CDATA[ Doktorand: Marina Panek ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[IBD, microbiota, blood biomarker, tissue, translational research, clinical research]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Inflammatory bowel disease (IBD) is a chronic gastrointestinal disorder with increase in incidence that severely deteriorates patients’ quality of life. The onset of the disease is mainly associated with the immune status, gut microbiota and food intake. The current scientific knowledge of specific triggers and diagnostic markers is limited; therefore, new data on gut microbiota, inflammatory, endocrine and nutritional status are required to better understand the IBD pathophysiology.It this study we will thoroughly explore host-gut microbiota interactions in order to define novel strategies for management of IBD.We will collect intestine biopsies, stool and blood samples from 40 newly diagnosed IBD patients and 20 non-IBD control individuals, as well as record their nutritional status. Since majority of the gut microorganisms are not culturable, we will use the in house available next-generation sequencing to characterize the composition of the microbiota in collected samples. Moreover, specific blood biomarkers, including cytokines, growth factors and hormones, will be determined using novel and highly sensitive proximity extension assays, recently developed in our laboratories. Collectively, these results will support better stratification of patients and initiate an appropriate therapy.]]></summary_en></project><project>
<id>2693</id><title_hr><![CDATA[Između Dunava i Mediterana. Uloga rimske vojske u mobilnosti ljudi i roba na tlu Hrvatske u antici. ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4028</user_id><user_firstLast_name>Mirjana Sanader</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-6088</code><acronim><![CDATA[RoMiCRO]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Arheologija, </scie_field_hr><scie_field_en>Archeology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>17731</team_members_id><team_members_names><![CDATA[ Doktorand: Mirna Vukov ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Roman Empire, Danube, Mediterranean, mobility, economy, Roman military, local elite.]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The objective of the project is to investigate and extend scientific information to aid in solving as yet unanswered questions about the significance of the Roman military in changes that occurred on the territory of Republic of Croatia in the period from the first contacts with Rome (229 BC) to the end of the Marcomannic Wars (180 AD). The geopolitical strategy of Rome in conquered regions was to encourage the integration process, where the Roman army gave its contribution. Archaeological data testify that the indigenous communities of Illyricum reacted differently to this process. Some were willing to accept the Roman heritage (e.g. Liburnians), while the others (e.g. Delmatae) were providing resistance. Given previous research today we have a number of valuable studies about certain aspects of Roman domination. However, they are primarily focused either on the ancient written sources or the archaeological material from Dalmatia and Pannonia. This research of the integration would cover for the first time the Roman military presence on the area of Croatia. The main focus is on the Roman military sites along the Dalmataean and the the Danube limes. New data will be derived using the methodology purposely created for this project and includes archaeological survey, classification, comparison and evaluation of all available data both archaeological and ancient sources with the application of the variable of geographic origin. Such research has never been undertaken in Croatia. The results would fill the informational gaps that exist for this part of the Empire through the analysis of the largest possible amount of information about the Roman army activities and the integration of indigenous people. The project leader’s research has focused so far on the problems of Roman provincial archaeology. Many years of her successful research of and of all the collaborators guarantee the sustainability of the approach and the successful implementation of the project objectives.]]></summary_en></project><project>
<id>2694</id><title_hr><![CDATA[Molekularna epidemiologija nekih invazijskih oboljenja divljih životinja]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3919</user_id><user_firstLast_name>Dean Konjević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-2264</code><acronim><![CDATA[EpiMol]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Veterinarska medicina, </scie_field_hr><scie_field_en>Veterinary medicine, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Veterinarski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Veterinary Medicine]]></institution_en><team_members_id>17766</team_members_id><team_members_names><![CDATA[ Doktorand: Miljenko Bujanić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[molecular epidemiology, wildlife, parasitology, MHC genes, GIS modelling]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Wildlife diseases are increasingly important field of veterinary medicine, conservation medicine, and protection of human health. Of all wildlife diseases parasitic diseases participate with 75%. In this project, selection of diseases encompasses potentially fatal diseases with high economic impact, frequently present disease with mainly subclinical course, and potential zoonotic diseases. Main objectives of the project are to: 1) determine the occurrence of selected parasitic diseases of gastrointestinal and respiratory system in red deer, roe deer, wild boar and jackal, 2) determine environmental factors that contribute disease occurrence, 3) determine the epidemiology of selected parasitic disease of wildlife, 4) analyse MHC genes expression in animals with different health status, and 5) analyse obtained results with molecular epidemiology tools. This will be achieved by interdisciplinary research team (composed of veterinarians, biologists and forester) divided in four main topics: parasitology, environmental conditions and GIS modelling, MHC genes polymorphism in wildlife and epidemiology and molecular epidemiology. Other objectives of the project are to facilitate establishment of internationally competent multidisciplinary research team through research, cooperation and continuing professional development and to enhance development of molecular epidemiology in Croatia. With such comprehensive approach proposed project offers for the first time in Croatia creation of multidisciplinary team that will analyse all aspects of wildlife diseases and important environmental factors. Furthermore, molecular epidemiology will provide insights into susceptibility to disease and potential survival rate that is dependent on major histocompatibility complex variations.]]></summary_en></project><project>
<id>2695</id><title_hr><![CDATA[Constraining AGN feedback through cosmic times: Paving the way for the next generation radio facilities]]></title_hr><title_en><![CDATA[]]></title_en><user_id>11144</user_id><user_firstLast_name>Vernesa Smolcic</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-4630</code><acronim><![CDATA[]]></acronim><duration></duration><status>Prekinut</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>19125</team_members_id><team_members_names><![CDATA[ Doktorand: Nikola Baran ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>2696</id><title_hr><![CDATA[Hijerarhijska konsolidacija velikih potrošača temeljena na upravljanju za integraciju u napredne mreže]]></title_hr><title_en><![CDATA[]]></title_en><user_id>7612</user_id><user_firstLast_name>Mario Vašak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-7386</code><acronim><![CDATA[3CON]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>17458</team_members_id><team_members_names><![CDATA[ Doktorand: Hrvoje  Novak ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[optimal control, hierarchical control, building, railway traffic system, energy consumption, power flow optimisation, prosumer, smart grid]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Buildings and railway traffic systems are examples of complex technical systems that consume significant energy amounts so as to enable their inner processes to evolve as required. Thereby the requirements on dynamic functioning of these systems can be achieved by different system interactions, whereas some of them are more preferable than the others from the standpoints of energy consumption or other criteria like price of operation or equivalent pollution.The global objective of the project 3CON is to research and develop optimal control techniques on significantly different large consumers – building systems and railway traffic systems – in conceptually identical way: by applying the principle of hierarchical decomposition of systems and cooperative optimal controls between the hierarchy levels. In that way the computed energy consumption profile on the lower level directly maximizes the global economic gain of the system operation in the presence of system constraints (e.g. allowed temperatures or fixed train travelling time). This will enable the proactive role of these largest consumers in energy grids of the future (smart grids). It will make them responsive and in position to best exploit the imposed varying energy exchange terms. Thereby vast possibilities in energy grid management through dynamic pricing will be opened – foremost for reducing losses between generation and consumption points in the grid and increasing grid reliability. The secondary global objective of this installation grant is to build an internationally competent research group in control of energy-intensive systems on the Faculty which is also recognized and accepted by relevant domestic companies.The project developments will be verified through building and railway traffic case studies that will be supervised by relevant Croatian companies. This will ensure that all relevant system issues are taken care of in the design and that the design itself is close to exploitation.]]></summary_en></project><project>
<id>2697</id><title_hr><![CDATA[Očuvanje genofonda šumskog drveća u svjetlu klimatskih promjena]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5275</user_id><user_firstLast_name>Mladen Ivanković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-9784</code><acronim><![CDATA[ConForClim]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Šumarstvo, </scie_field_hr><scie_field_en>Forestry, </scie_field_en><institution_hr><![CDATA[Hrvatski šumarski institut]]></institution_hr><institution_en><![CDATA[Croatian Forest Research Institute]]></institution_en><team_members_id>17850</team_members_id><team_members_names><![CDATA[ Doktorand: Sanja Mrmić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Genetic conservation, Climate changes, Forest , provenance trials, variability, Quercus robur, Fagus sylvatica ]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The preserving of the genetic diversity of the forest types is the basis for sustainable management and conservation of the natural composition of the forests. Natural forests make up 95% of the total forests in Croatia and in its wealth geographic region contains different ecological types and a large number of the forest tree species. Global climate changes, rising temperatures, falling rainfall, occurrence of the extreme weather events directly affect on genetic diversity. The main objective of the proposed project is to make recommendations for the conservation of the genetic diversity of the forest trees. Precondition for achieving the goal is the identification and understanding of the genetic variability of the individual tree species. The research to be carried out by the project would be based on the common oak and beech. On existing genetic tests that were established at different sites, data on the survival and growth of plants, phenology, silvicultural properties, plant resistance to pests, etc should be collect. The stem forest stands from which the seed was taken will be used for collecting the data of health condition, fruiting and climatic parameters. The genetic diversity of the provenance will be analyzed by DNA markers. This project should be continued and expanded research on the identification of proven European beech resistant to drought, which are conducted in the framework of a bilateral cooperation with Germany (MSES-DAAD 2013/14) and the preservation of the gene pool and study of the variability of our most important tree species which are conducted as part of the project “Breeding and forest seed” supported by MSES of Croatia. From the economic point of view, the project aims is to raise the category of the forest reproductive material (FRM) in a higher category according to the Law of FRM (Official Gazette 75/2009, 61 /2011 - EU directive EC/105/99). Higher category guarantees a higher quality, and thus a higher price in the market.]]></summary_en></project><project>
<id>2698</id><title_hr><![CDATA[Moderne i suvremene umjetničke mreže, umjetničke grupe i udruženja: Organizacijski i komunikacijski modeli suradničkih umjetničkih praksi 20. i 21. stoljeća]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6142</user_id><user_firstLast_name>Ljiljana Kolešnik</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-5766</code><acronim><![CDATA[ARTNET]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Povijest umjetnosti, </scie_field_hr><scie_field_en>Art history, </scie_field_en><institution_hr><![CDATA[Institut za povijest umjetnosti]]></institution_hr><institution_en><![CDATA[Institute of Art History, Zagreb]]></institution_en><team_members_id>17659</team_members_id><team_members_names><![CDATA[ Doktorand: Nikola Bojić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[history of art, methodology, artist networks, art groups, social networks, data visualization, Croatian modern art, Croatian contemporary art]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Research topics of this project are the organization and communication models embedded into artist networking and artist collaborative practices of the 20th and 21st century, as they are manifested in the Croatian art of that period. Project initial hypothesis is that artist networks, art groups and art associations form the most important platform of cultural exchange in modern and contemporary visual arts due to the similarity of underlying organization and communication models regardless of geo-cultural location at which they appear. A degree of their diversity in art practice of particular local community at particular historical moment is proportional to the dynamics and volume of its participation in the international/cross-cultural exchange. To prove our hypothesis and identify, describe and explain these organization and communication models as generally applicable – which is the main objective of the project - we shall investigate Croatian artist networking and collaborative practices on the background of similar phenomena in other European countries and with regard to poetic requirements of different periods in modern and contemporary art, conventions of social interactions and available techniques/technologies of communication. As the methodology of art history does not meet the complexity of the research topic, we shall develop interdisciplinary methodological apparatus combining knowledge and analytic tools of art history, sociology and information science. Considerable amount of data collected through the extensive infield research will be stored in Croatian Artists Networks Information System developed in the course of the project and supporting network visualization techniques as a cognitive research tool for experimental presentation of our research results framed with the appropriate structural narratives (textual, visual, GIS data). Project results will be also presented in 2 books, 7 articles and at the closing international conference.]]></summary_en></project><project>
<id>2820</id><title_hr><![CDATA[Znanstvena aktivnost, suradnja i orijentacija istraživanja u društvenim znanostima u Hrvatskoj i ostalim postsocijalističkim europskim zemljama]]></title_hr><title_en><![CDATA[Research activity, collaboration and orientation in social sciences in Croatia and other post-socialist European countries]]></title_en><user_id>6932</user_id><user_firstLast_name>Marija Maja Jokić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-9351</code><acronim><![CDATA[RACOSS]]></acronim><duration>15.09.2015 - 14.09.2019</duration><status>Završio</status><financ_value>70.182,49 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Informacijske znanosti, Ekonomija, Pravo, Politologija, Sociologija, Psihologija, Pedagogija, Edukacijsko-rehabilitacijske znanosti, Socijalne djelatnosti, </scie_field_hr><scie_field_en>Information sciences, Economy, Law, Political Science, Sociology, Psychology, Pedagogy, Physical education and rehabilitation sciences, Social work, </scie_field_en><institution_hr><![CDATA[Institut za društvena istraživanja]]></institution_hr><institution_en><![CDATA[Institute for Social Research in Zagreb]]></institution_en><team_members_id>7722, 11177, 12381, 11224, 6920, 7724, 12373, 12341, 20965, </team_members_id><team_members_names><![CDATA[Dejana Bouillet, Andrea Mervar, Krešimir Kufrin, Darja Maslić Seršić, Nikola Petrović, Sonja Špiranec, Dora Zgrabljić Rotar, Tonči  Kursar, Stjepan Mateljan, ]]></team_members_names><keywords_hr><![CDATA[znanstvena aktivnost, citatne analize, znanstvena suradnja, analiza društvenih mreža¸ nacionalni časopisi, društvene znanosti, Hrvatska, EU zemlje]]></keywords_hr><keywords_en><![CDATA[research performance, citation analysis, collaboration, social network analysis, natioanl journals, social sciences, Croatia, EU countries]]></keywords_en><summary_hr><![CDATA[Temeljna funkcija znanosti, posebno društvenih, je utjecaj na razvoj društva. Status društvenih znanosti u društvu, kao i njihov utjecaj na razvoj, manje su istraživane teme u odnosu na prirodne i primijenjene znanosti.U Hrvatskoj se društvenim znanostima bavi približno četvrtina registriranih znanstvenika vezanih najvećim dijelom uz rad 7 instituta i svih 7 sveučilišta. Glavna istraživačka pitanja ovog projekta su: Kojim temama i kakvom problematikom se bave ti stručnjaci? Gdje objavljuju rezultate svojih istraživanja? Surađuju li međusobno unutar ustanova, na razini zemlje i na međunarodnoj razini? U kojoj mjeri su rezultati njihovih istraživanja dostupni i prepoznati kroz citiranost? Kakav je značaj i uloga nacionalnih časopisa iz društvenih znanosti u prijenosu i dostupnosti znanja? Postoje li razlike u obrascima znanstvenog komuniciranja u pojedinim poljima društvenih znanosti i koje su? Kako bi se dobila što cjelovitija slika stanja u Hrvatskoj, u projekt su uključene europske post-socijalističke zemlje, 10 EU zemalja i zemlje bivše Jugoslavije. Za ostvarivanje postavljenih ciljeva koristit će se kvantitativni (bibliometrija, upitnici, analiza društvenih mreža) i kvalitativni (intervjui) metodološki pristupi koje je osmislio i provodit će interdisciplinarni tim stručnjaka. Temeljni izvor podataka o produktivnosti, citiranosti, autorstvu, suradnji, časopisima, ustanovama i zemljama je baza Scopus. Za statističke podatke o zemljama koristi će se Eurostat i razni nacionalni izvori.Očekivani doprinosi projekta su teorijski i primijenjeni, od uvida u znanstveni potencijal u istraživanjima društvenih znanosti uključenih zemalja, preko razvoja i primjena kompleksne metodologije prikupljanja i obrade raznovrsnih podataka, do ponude relevantnih elementa hrvatskoj znanstvenoj politici i indikatora za razvoj i primjenu prihvatljivijih sustava za vrednovanje znanstvenog rada te pomoć pri donošenju vezanih odluka.]]></summary_hr><summary_en><![CDATA[A basic function of science, especially social science, is its influence on the development of society. The status of social science and its influence on the development of society are less researched themes in comparison with natural and applied sciences.Nearly a quarter of registered Croatian scientists are social scientists. Their work is, in most part, tied to the work of 7 scientific institutes and all 7 universities. The main research questions in this project are: Which themes and problematic are central to these experts? Where do they publish the results of their research? How much do they cooperate on institutional, country and international level and are there measurable effects of cooperation? To what extent are their results available and recognized through citations? What is the significance and role of national journals in social sciences? What are the differences between various fields of social sciences?To provide a rich comparative description of the state of social sciences in Croatia, the project includes 10 EU post-socialist countries as well as ex-Yugoslav countries. To attain its goals the project will use quantitative (bibliometry, survey, social network analysis) and qualitative (interviews) methods which have been planned and will be implemented by a multidisciplinary team of experts. The primary source for bibliometric data for productivity, impact, authorship, cooperation, journals, institutions and countries will be the Scopus citation index. The main source for statistical data about the included countries will be Eurostat and various national sources.The expected outcomes of the project are theoretical and applied, from insight in scientific potential of social science research in included countries, through the development of appropriate methods of collecting and analyzing different types of data, to offering the relevant elements and indicators for the evaluation of scientific output and as help in related decision making processes.]]></summary_en></project><project>
<id>2834</id><title_hr><![CDATA[Patofiziološke posljedice promjena sastava lipidnih splavi]]></title_hr><title_en><![CDATA[Pathophysiological consequences of lipid raft changes]]></title_en><user_id>4409</user_id><user_firstLast_name>Marija Heffer</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-2324</code><acronim><![CDATA[RafTuning]]></acronim><duration>10.12.2015 - 09.06.2021</duration><status>Završio</status><financ_value>130.743,91 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, Farmacija, </scie_field_hr><scie_field_en>Basic Medical Sciences, Pharmaceutical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Medicinski fakultet Osijek]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Medicine]]></institution_en><team_members_id>12600, 12492, 13131, 2737, 4439, 4511, 12488, 4384, 4379, 12468, 4417, 13292, 4420, 13221, 13217, 13317, 4473, 23157, 23158, 23159, 23162, 23166, 23167, 23165, 23171, </team_members_id><team_members_names><![CDATA[Svjetlana Kalanj Bognar, Kristina Mlinac, Dragana Fabris, Jasenka Wagner, Barbara Viljetić, Vedrana Ivić, Ivana Škrlec, Marta Balog, Senka Blažetić, Valentina Pavić, Robert Blažeković, Željka Vukelić, Irena  Labak, Milan Mesić, Melita Čačić Hribljan, Zrinka Požgain, Stefan Mrđenović, Alen Imširović, David Andrijevic, Kiš Ana, Tihana Mendeš, Martina Matanović, Tea Markulak, Mateo Čupić, Andrijana Včeva, ]]></team_members_names><keywords_hr><![CDATA[lipidne splavi, gangliozidi, živčani sustav, inhibitori glikolipida, stres, epigenetika]]></keywords_hr><keywords_en><![CDATA[lipid rafts, gangliosides, nervous system, glycolipid inhibitor, stress, epigenetics]]></keywords_en><summary_hr><![CDATA[Lipidne splavi su područja stanične membrane koja okupljaju lipide i 35% proteina membrane u dinamične strukture zvane signalosomi. Glavne molekule koje sudjeluju u izgradnji lipidnih splavi su kolesterol, sfingomijelin i glikosfingolipidi. Najmanje 11% transmembranskih proteina ovisi o glikosfingolipidima, posebice gangliozidima, koji osiguravaju pravilnu strukturu i funkciju lipidnih splavi.  Promjene u sastavu glikosfingolipida moduliraju kritične korake u fiziološkim procesima kao što su adhezija, signalizacija, formiranje barijera, stanična migracija, vezikularni transport i apoptoza. Također, rani su pokazatelji neurodegenerativnih poremećaja (Alzheimer i Parkinson). Mehanizmi koji dovode do promjena nisu dovoljno istraženi i ne postoje terapije usmjereno na lipidne splavi kod liječenja neurodegenerativnih bolesti i pospješivanja regeneracije. Cilj istraživanja je testirati jeli sastav lipidnih splavi narušen kod genetički izmijenjenih miševa s nedostatkom u sintezi gangliozida, jeli se mijenja pod utjecajem stresa i u procesu starenja te može li se farmakološki manipulirati satavom lipidnih splavi. U svrhu dokazivanja postavljene hipoteze utvrditi će se promjene u sastavu lipidnih splavi i transkriptomu središnjeg i perifernog živčanog sustava kod miševa s nedostatkom u sintezi gangliozida odnosno na  štakorskom modelu kroničnog stresa i starenja. Sintetizirati ćemo inhibitore ključnih enzima u metabolizmu glikolipida koji bi mogli poslužiti u farmakološkim intervencijama i dalje ih sistematizirati  prema djelovanju na sastav lipidnih splavi u kulturama živčanih stanica i na mišjem modelu. Kombinacijom lipidomičkog i transkriptomičkog pristupa odabrat će se kritični signalni putovi i utvrditi njihov učinak na epigenetske promjene. Genetički, okolišem i farmakološki inducirane promjene u sastavu lipidnih splavi dati će uvid u njihovu funkciju i omogućiti razvoj lijekova namijenjenih finom ugađanju  procesa kao što su reakcija na stres i regeneracija.]]></summary_hr><summary_en><![CDATA[Lipid rafts are liquid ordered sub-compartments of plasma membrane which co-cluster lipids and 35% of plasma-membrane proteins in dynamic structures called signalosomes. Cholesterol, sphingomyelin and glycosphingolipids are the major constituents and organizers of lipid rafts. At least 11% of transmembrane proteins depend on glycosphingolipids, particularly gangliosides, as lubricant enabling proper raft location and function. Changes in composition of glycosphingolipids interfere with fine tuning of critical physiological processes like adhesion, signaling, forming barriers, cell migration, vesicular transport and apoptosis. Although changes in the ganglioside content of lipid rafts are the first sign of neurodegenerative diseases like Alzheimer and Parkinson, mechanisms causing changes are not fully explored and there are no relevant clinical treatments targeting rafts in neurodegeneration or regeneration. With this proposal we aim to test whether the content of lipid rafts is disrupted in knockout mice for the key enzymes in ganglioside synthesis, affected in stress and aging and could it be successfully tuned by pharmacological manipulation. In order to test this hypothesis we will map the changes in lipid rafts and the transcriptome of CNS and PNS of ganglioside-deficient knockout mice and rat models of aging and chronic stress. Potential pharmacological substances, inhibitors of key enzymes in glycolipid metabolism, will be synthesized and further selected according to their efficacy to affect the composition of lipid rafts in cultured neurons and the mouse models. Combinations of lipidomic and transriptomic approaches will be used to select critical signaling pathways which would be tracked down to epigenetic changes.  Genetically, environmentally and pharmacologically introduced changes in lipid rafts would give insight in their function and enable development of drugs for fine tuning of processes like stress responses and regeneration.]]></summary_en></project><project>
<id>2841</id><title_hr><![CDATA[Uloga nekodirajućih RNA u regulaciji latencije herpes simplex virusa 1]]></title_hr><title_en><![CDATA[Roles of non-coding RNAs in regulation of herpes simplex virus 1 latency]]></title_en><user_id>43</user_id><user_firstLast_name>Igor Jurak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-8790</code><acronim><![CDATA[ON-OFF-IJ]]></acronim><duration>01.05.2015 - 30.09.2019</duration><status>Završio</status><financ_value>132.688,02 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Fakultet biotehnologije i razvoja lijekova]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Biotechnology and Drug Development]]></institution_en><team_members_id>894, 858, 19184, 17801, 19177, 17845, </team_members_id><team_members_names><![CDATA[Marko Hohšteter, Hackenberg Michael, Maja Cokarić Brdovčak, Marina Matešić, Andreja Zubković, Maja Badurina, ]]></team_members_names><keywords_hr><![CDATA[mikroRNA, miRNA, virus, latencija, herpesvirus, herpes simplex, regulacija gena]]></keywords_hr><keywords_en><![CDATA[microRNA, miRNA, virus, latency, herpesvirus, herpes simplex, gene regulation, ]]></keywords_en><summary_hr><![CDATA[Herpes simplex virus 1 (HSV - 1) je važan patogen ljudi koji uzrokuje razna oboljenja, međutim usprkos  intenzivnim istraživanjima i velikom broju iznimnih otkrića, mnogi temeljni aspekti HSV - 1 biologije su nepoznati. Nedavnim tehničkim postignućima koja su omogućila analize  transkriptoma, postalo jasno da nekodirajuće RNA (ncRNA), koje između ostalih uključuju i miRNAs i duge ncRANs ( lncRNA ), imaju vrlo važnu ulogu u regulaciji genske aktivnosti životinja, biljaka i virusa. Naša grupa je otkrila brojne HSV -1 eksprimirane miRNA, no njihova funkcija je uglavnom nepoznata. S druge strane, već duže je poznato nekoliko HSV - 1 kodiranih lncRNAs, uključujući i intenzivno proučavan tzv. eng. latency associated transcript (LAT), glavni marker HSV - 1 latencije; ali i njihova funkcija je slabo poznata i uglavnom neistražena. Naša je hipoteza da ncRNAs imaju središnju ulogu u replikaciji ovog virusa i uspostavi latencije, posebice u regulaciji prijelaza iz latencije u litičku fazu (i.e. latentnog/litičkog prekidača). U našim nastojanjima odrediti ćemo nekodirajući transkriptom HSV-1 te odgonetnuti ulogu ncRNA u regulaciji genske aktivnosti tjekom litičke i latente faze HSV-1. Naše hipoteze temeljimo na preliminarnim podacima istraživanja funkcije miR-H1 i miR-H6, miRNA virusa koje su obilno izražena tijekom litičke i /ili latentne infekcije. U prethodnom istraživanju smo generirali virusnu mutantu koja ne eksprimira miRH1 i –H6 i preliminarni rezultati ukazuju na smanjenje patogenosti i smanjenu sposobnosti reaktivacije. U daljenjm radu ćemo uz pomoć bioinformatike i najsuvremenijih tehnika molekularne biologije utvrditi ciljne molekule ovih i drugih miRNAs , te  odrediti njihovu ulogu u infekciji. Osim toga , kako bi omogućili primjenu visoko-protočnih tehnologija u proučavanju latencije, uspostaviti ćemo in vitro model HSV-1 latencije; koji temeljimo na našim prethodnim i preliminarnim istraživanjima u kojima smo karakterizirali ekspresiju HSV - 1 miRNAs u nekoliko takvih modela. Ovaj pristup također će nam omogućiti osjetljivo testiranje tzv. latentnog/litičkog prekidača i biokemijski pristup u proučavanju interakcije ncRNA-protein.]]></summary_hr><summary_en><![CDATA[Herpes simplex virus 1 (HSV-1) is an important human pathogen that causes a variety of diseases. However, in spite of intensive studies and remarkable discoveries, many fundamental aspects of the HSV-1 biology are unknown. Recently, with expansion of transcripome analyses, it become apparent that non-coding RNAs (ncRNA), including miRNAs and long ncRANs (lncRNA), have immense role in regulation of genes of animals, plants and viruses. We have discovered numerous miRNAs expressed by HSV-1, functions of which are mostly unknown. On the other hand, a few HSV-1 encoded lncRNAs have been discovered many years ago, including intensively studied latency associated transcript (LAT), but function of these remains largely elusive and not investigated. We hypothesize that miRNAs and other ncRNAs have a central role in virus gene regulation and efficient establishment of latency, particularly the control of the lytic-latent switch (reactivation from latency). We seek to determine the complete ncRNA transcriptome of HSV-1 and understand its roles in regulation of gene expression during lytic and latent HSV-1 infection. Our study is founded on preliminary data focusing on small set of miRNAs, i.e. functions of miR-H1 and miR-H6, HSV-1 miRNAs abundantly expressed during lytic infection and/or latent infection. We have generated the HSV-1 mutant with miR-H1/H6 locus deleted, and our results indicate that these miRNA are important for virus pathogenesis. Using bioinformatics and cutting-edge molecular biology techniques we will identify targets of this and other miRNAs and reveal their function in infection. Moreover, to enable high-throughput technologies in studying latency, we will establish an in vitro latency model. In preliminary attempts, we have characterized the expression of HSV-1 and host miRNAs in such models. This approach will also allow sensitive probing of the latent/lytic switch and biochemical approaches to study ncRNA-protein interactions.]]></summary_en></project><project>
<id>2848</id><title_hr><![CDATA[Tranzicija i tradicija u špilji Vlakno: Model prijelaza paleolitika u mezolitik na području Sjeverne Dalmacije]]></title_hr><title_en><![CDATA[Transition and tradition in Vlakno cave: Modelling the Palaeolithic-Mesolithic transition in Northern Dalmatia]]></title_en><user_id>499</user_id><user_firstLast_name>Dario Vujević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2014-09</proposal_call><code>UIP-2014-09-1545</code><acronim><![CDATA[Vlakno]]></acronim><duration>01.05.2015 - 30.04.2018</duration><status>Završio</status><financ_value>40.380,91 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Arheologija, </scie_field_hr><scie_field_en>Archeology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zadru]]></institution_hr><institution_en><![CDATA[University of Zadar]]></institution_en><team_members_id>2993, 12898, 12720, 6111, 2744, </team_members_id><team_members_names><![CDATA[Barbara Cvitkušić, Mario Bodružić, Zlatko Perhoč, Mate Parica, Siniša Radović, ]]></team_members_names><keywords_hr><![CDATA[Vlakno, paleolitik, mezolitik, epigravetijen, holocen]]></keywords_hr><keywords_en><![CDATA[Vlakno, Palaeolithic, Mesolithic, Epigravettian, Holocene]]></keywords_en><summary_hr><![CDATA[Projekt „Tranzicija i tradicija u špilji Vlakno: Model prijelaza paleolitika u mezolitik na prostoru Sjeverne Dalmacije“ je nastavak interdisciplinarnih istraživanja paleolitičkog i mezolitičkog nalazišta Vlakno na Dugom otoku, kao i šireg područja samog otoka. Špilja Vlakno trenutno je jedino nalazište Sjeverne Dalmacije dostupno za proučavanje prijelaza paleolitika u mezolitik, kontinuiteta i diskontinuiteta naseljavanja prostora, kulture, te teritorijalne organizacije. Tijekom proteklih 10 godina istraživačke aktivnosti bile su inkorporirane u različite znanstvene projekte, a slijedeći cilj je dobiti dublji uvid u život i ponašanje prapovijesnih zajednica. Kombiniranjem terenskih istraživanja, kabinetskog rada i različitih analiza pokušat će se odrediti interakcija pećine s okolišem, s ciljem dobivanja podataka koji se mogu usporediti s drugim nalazištima jadranske obale. Nova istraživanja špilje Vlakno doprinijet će proučavanju gornjeg paleolitika i mezolitika Europe, na području koje je do sada bilo relativno slabo istraženo. Uz to Vlakno bi moglo poslužiti za izradu teorijskog modela prijelaza paleolitika u mezolitik, koji bi bio primjenjiv za šire područje.Predloženi projekt trebao bi obogatiti naše spoznaje o kulturi življenja i društvenim odnosima paleolitičkih i mezolitičkih zajednica. Pomoći će u definiranju načina na koji su ljudske zajednice mijenjale svoje ponašanje zbog globalnog zatopljenja, te predložiti teorijski i empirijski model prijelaza na drugačije klimatske i okolišne uvjete holocena. Projekt će pružiti važne informacije na temu naseljavanja i kretanja zajednica u jednom klimatski nestabilnom razdoblju.]]></summary_hr><summary_en><![CDATA[Project “Transition and tradition in Vlakno cave: Modelling the Palaeolithic-Mesolithic transition in Northern Dalmatia” will continue the interdisciplinary research of Palaeolithic and Mesolithic site of Vlakno on Dugi Otok. Vlakno cave is currently the only site in northern Dalmatia available for studying Palaeolithic/Mesolithic transition, continuity and discontinuity of settlement, Palaeolithic and Mesolithic culture, territorial organization, etc. Over the past 10 years research activities were incorporated in different scientific projects, but our primary objective is to get further insights into the way of life of prehistoric communities. Combination of field work, cabinet studies and analyses will be used to determine interaction of cave with environment in order to obtain data comparable with other sites on the Adriatic coast. New research of Vlakno cave will contribute new data to the study of the European Upper Palaeolithic and Mesolithic from a relatively understudied area. Also Vlakno cave could set a theoretical model of Paleolithic-Mesolithic transition, applicable to a wider area. The proposed project should significantly enrich the knowledge on the culture of living and social relations of Palaeolithic/Mesolithic communities. It will help define the ways in which humans modified their behaviour in response to global warming and sea-level rise and propose stronger theoretical and empirical model of transition to different climatic and environmental conditions of Holocene. Project will also provide important information on Adriatic human settlement and migration patterns during this climatically unstable period. ]]></summary_en></project><project>
<id>2872</id><title_hr><![CDATA[Generalizirana geometrija i simetrije]]></title_hr><title_en><![CDATA[Generalized Geometry and Symmetries]]></title_en><user_id>52</user_id><user_firstLast_name>Larisa Jonke</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-3258</code><acronim><![CDATA[GGSymm]]></acronim><duration>01.09.2015 - 30.09.2019</duration><status>Završio</status><financ_value>79.102,79 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>5035, 5014, 471, 22491, 24502, 25067, 25315, </team_members_id><team_members_names><![CDATA[Athanasios Chatzistavrakidis, Ivan Andrić, Danijel Jurman, Clay James Grewcoe, Fech Scen Khoo, Grgur Šimunić, Georgios Karagiannis, ]]></team_members_names><keywords_hr><![CDATA[generalizirana kompleksna geometrija, nekomutativna geometrija, baždarne teorije, matrični modeli, fuzzy prostorir]]></keywords_hr><keywords_en><![CDATA[generalized complex geometry, non-commutative geometry, gauge theory, matrix models, fuzzy spaces]]></keywords_en><summary_hr><![CDATA[Ujedinjenje Einsteinove teorije opće relativnosti s kvantnom fizikom predstavlja jedan od najvećih izazova moderne teorijske fizike. Jedna pretpostavka zajednička svim istraživačkim smjerovima usmjerenih ka razumijevanja kvantne teorije gravitacije jest  da  za  opis geometrije prostor-vremena nije dostatna  klasična slika prostor-vremena kao diferencijabilne mnogostrukosti. U okviru ovog projekta smo zainteresirani za generalizirane geometrije motivirane fizikom teorije struna; generalizirana kompleksna geometrija i nekomutativna geometrija. Naš cilj jest  bolje razumijevanje  kako spomenute ideje generalizirane geometrije   iskoristiti u generalizaciji načela simetrije. Konkretno, zainteresirani smo za proširenje baždarnog principa, ključne ideje koji se koristi u fizici za opis svih (poznatih) međudjelovanja materije, a u svjetlu ovih proširenja klasične geometrije. Želimo opisati učinke dualnosti u teoriji struna, nekomutativne baždarne teorije te  viših baždarnih teorija u okviru učinkovne teorija polja koja nam je potrebne za obavljanje pouzdanih izračuna koje je moguće eksperimentalno provjeriti. Očekujemo da će nam geometrizacija ovih poopćenih simetrija pružiti, u dugogodišnjoj perspektivi, konzistentan okvir unutar kojeg bi se mogla riješiti neka od otvorenih pitanja u kozmologiji i fizici crnih rupa.]]></summary_hr><summary_en><![CDATA[The unification of Einstein&#39;s theory of general relativity with quantum physics represents one of the greatest challenges of modern theoretical physics. A hypothesis common to all research directions aiming at understanding the quantum theory of gravity is that our description of space-time geometry has to go beyond the classical picture of space-time as a differentiable manifold.  Within this project we are interested in generalized concepts of geometry, physically motivated by string theory: generalized complex geometry and non-commutative geometry. We aim at improving our understanding on how these generalized notions of geometry could be utilized to obtain consistent extensions of symmetry principles. In particular, we are interested in extending the gauge principle, the key physical notion used to describe all (known) matter interactions, in view of the above generalizations of classical geometry. Our goal is to capture the effects of string duality symmetries, non-commutative gauge theory and higher gauge theories at the level of the effective field theory description, which is necessary in order to perform reliable calculations and yield experimentally testable predictions. We expect that geometrizing these generalized symmetries would provide us, as a long-term perspective, with a consistent framework within which one could address open issues in cosmology and black-hole physics.]]></summary_en></project><project>
<id>2873</id><title_hr><![CDATA[Supramolekulska kontrola fotokemijskih reakcija eliminacije]]></title_hr><title_en><![CDATA[Supramolecular control of photoeliminations]]></title_en><user_id>376</user_id><user_firstLast_name>Nikola Basaric</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-6312</code><acronim><![CDATA[SupraPhotoE]]></acronim><duration>01.06.2015 - 31.08.2019</duration><status>Završio</status><financ_value>122.370,43 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>698, 3215, 3336, 3493, 3001, 566, 647, 1205, 20718, 22526, 24377, </team_members_id><team_members_names><![CDATA[Kata Majerski, Marija Alešković, Margareta  Sohora, Đani Škalamera, Leo Mandić, Ivana Antol, Lidija Uzelac, Iva Dzeba, Matija Sambol, Antonija Husak, Katarina Zlatić, ]]></team_members_names><keywords_hr><![CDATA[fotokemija, supramolekulska kemija, karbeni, policikličke molekule, ftalimidi, kinon-metidi,]]></keywords_hr><keywords_en><![CDATA[photochemistry, supramolecular chemistry, carbenes, polycyclic molecules, phthalimides, quinone methides]]></keywords_en><summary_hr><![CDATA[Dinamika supramolekulskih sustava omogućava kontrolu fotokemijske reaktivnosti i otvara mogućnosti za reakcije koje se konvencionalnim postupcima sinteze, termičkim reakcijama u izotropnoj otopini ne mogu provesti. Glavna strategija predloženog projekta je primijeniti različite supramolekulske sustave za kontrolu fotokemijske reaktivnosti. Očekuje se da će predloženo istraživanjo povećati fundamentalna znanja iz supramolekulske kemije, fotofizike i fotokemije policikličkih molekula u izotropnim medijima i supramolekulskim kompleksima. Istraživanje će biti usmjereno na tri reakcije fotoeliminacije: eliminaciju dušika iz diazirina i diazo prekursora uz nastajanje karbena, fotodekarboksilaciju različitih derivata aktiviranih s ftalimidnim kromoforom i fotodehidrataciju i deaminaciju kojom nastaju kinon-metidni intermedijeri. Aspekti kojima ćemo se baviti su učinak molekulske geometrije na reaktivnost i konstantu stabilnosti inkluzijskih kompleksa, kao i utjecaj kompleksiranja na fotofizička svojstva različitih kromofora, učinkovitost fotokemijskih reakcija i raspodjelu produkata. U vezi s predloženim istraživanjem bit će neophodno provesti sintezu velikog broja molekula, dobro definirane i u nekim slučajevima i iznimno složene strukture, što će sigurno zahtijevati značajne inovacije u sintetskoj metodologiji i razvoju postojećih tehnika. Znanstveni ciljevi projekta će ići dalje od trenutnih spoznaja kroz potragu za bio-medicinskim primjenama. Nizu spojeva će biti ispitana antiproliferativna aktivnost, pri čemu će se odrediti &#39;&#39;lead&#39;&#39; spojevi za daljnja istraživanja i potencijalni razvoj liječenja raka uz minimalne nuspojave.]]></summary_hr><summary_en><![CDATA[Dynamics of the supramolecular systems facilitates control of the photochemical reactivity and opens opportunities for reactions which cannot be conducted by conventional synthetic methods, in the thermal reactions in isotropic solution. The main strategy of the proposed project is to apply different supramolecular systems to control photochemical reactivity. The proposed research should increase the fundamental knowledge in supramolecular chemistry, photophysics and photochemistry of the polycyclic molecules in isotropic media and the supramolecular complexes. The research will be focused on three photoelimination reactions: extrusion of nitrogen from diazirines and diazo precursors (giving carbenes), photodecarboxylation of different derivatives activated by phthalimides, and photodehydration and photodeamination giving quinone methide intermediates. The aspects which we will address include the effects of molecular geometry on reactivity and stability constants of the inclusion complexes, as well as influence of the complexation on the photophysical properties of different chromophores, efficiency of the photochemical reactions and product distribution. In connection with the proposed investigations it will be necessary to synthesize a large number of well defined and in some cases extremely complex molecules which will certainly ask for substantial innovations in the synthetic methodology and development of the existing techniques. The scientific goals of the project will go beyond the state of the art and search for bio-medical applications. A series of compounds will be screened for antiproliferative activity, providing lead molecules for further research and potential development of cancer treatment with minimal side effects.]]></summary_en></project><project>
<id>2875</id><title_hr><![CDATA[Uloga oksidativnog stresa i opiorfina u temporomandibularnim poremećajima]]></title_hr><title_en><![CDATA[The role of oxidative stress and opiorphin in temporomandibular disorders  ]]></title_en><user_id>612</user_id><user_firstLast_name>Iva Alajbeg</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-3070</code><acronim><![CDATA[ROStrO-TMD]]></acronim><duration>01.10.2015 - 30.09.2019</duration><status>Završio</status><financ_value>115.896,87 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Dentalna medicina, Temeljne medicinske znanosti, Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Dental medicine, Basic Medical Sciences, Clinical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Stomatološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Dentistry]]></institution_en><team_members_id>6409, 6340, 5987, 3288, 4284, 3378, 5175, 6162, 21042, 24296, </team_members_id><team_members_names><![CDATA[Tomislav Badel, Dubravka Knezović Zlatarić, Ivan Alajbeg, Dunja Rogić, Dijana Zadravec, Lea Vuletić, Ana Andabak Rogulj, Maja Sabalić, Ema Vrbanović, Ivana Lapić, ]]></team_members_names><keywords_hr><![CDATA[temporomandibularni poremećaji, oksidativni stres, opiorfin, orofacijalna bol, ELISA, HPLC MS, slina]]></keywords_hr><keywords_en><![CDATA[temporomandibular disorders, oxidative stress,  opiorphin, orofacial pain, ELISA, HPLC MS, saliva]]></keywords_en><summary_hr><![CDATA[Temporomandibularni poremećaji (TMP) kronični su bolni poremećaji koji zahvaćaju čeljusni zglob, žvačne mišiće i okolna tkiva, s prevalencijom u populaciji od 3,6 do 7%. Patološki supstrat uglavnom izostaje, a uzrok je često nepoznat. Psihološki i mehanički stresni čimbenici mogu doprinijeti nastanku oksidativnog stresa (OS) i rezultirati TMP-om.Cilj je kvantificirati markere OS, totalni antioksidativni kapacitet (TAK) te nedavno izolirani endogeni peptid opiorfin (OP) u slini pacijenata s TMP-om i usporediti ih s kontrolnom skupinom. Kako kronična izloženost stresu može uzrokovati hiperalgeziju koja nastaje kao posljedica odgovora na stres u hipotalamičko-hipofizno-adrenalnoj (HHA) osi, cilj je istražiti ovaj mehanizam uspoređujući OP i markere OS s razinom salivarnog kortizola (SK).Hipoteze: OS ima ulogu u nastanku i održavanju TMP-a, stoga će markeri OS u slini rasti i/ili će se TAK smanjiti; opiorfin utječe na orofacijalne bolne sindrome kao što je TMP i njegove vrijednosti u slini će se razlikovati između bolesnika s TMP-om i kontrole. Poremećena HHA osovina je u podlozi povećanog OS i promjena razina OP u bolesnika s TMP-om.U 50 bolesnika s TMP-om (dijagnosticiranih pomoću kriterija i MRI nalaza) i 50 kontrolnih ispitanika sakupit će se slina. Za određivanje markera OS koristit će se ELISA sa spektrofotometrijom. Razine OP mjerit će se HPLC-MS/MS metodom koju smo sami razvili. Za određivanje SK koristit će se elektrokemiluminiscentna imunokemijska metoda s prethodnom ekstrakcijom.Pacijenti s TMP-om će biti randomizirani u 2 skupine (1:stabilizacijska udlaga + placebo tablete; 2:placebo udlaga + 1g vitamina C). Mjerenja će se ponoviti nakon 3 i 6 mjeseci. Praćenje OP, OS markera i SK tijekom tog razdoblja će, ovisno o promjenama simptoma TMP-a, dodatno rasvijetliti predloženi podliježeći mehanizam. Novi pristup u objašnjavanja neuroendokrinih mehanizama u TMP-u i uporaba sline kao neinvazivno pristupačne dijagnostičke tekućine predstavlja značajan napredak. ]]></summary_hr><summary_en><![CDATA[Temporomandibular disorders (TMD) are chronic painful conditions involving joints, masticatory muscles and associated tissues that affect 3.6-7% of the population. Observable pathology is mostly absent, and the cause is unknown. Psychological and mechanical stress factors could contribute to oxidative stress (OS) and lead to TMD. Aims are to quantify salivary OS markers and total antioxidant capacity (TAC) and to quantify recently isolated endogenous peptide opiorphin (OP) in saliva of TMD patients and compare them to controls. As chronic exposure to stress may cause hyperalgesia as a result of the stress response in the hypothalamic-pituitary-adrenal (HPA) axis, aim is to test this as an underlying mechanism by correlating OP and OS markers to salivary cortisol (SC) levels. Hypotheses: OS has a role in TMD onset and maintenance, thus salivary markers of OS will increase and/or TAC will decrease; OP influences orofacial pain syndromes, such as TMD, and its salivary level will differ between TMD patients and controls. Disbalanced HPA axis underlies the increase of OS and OP level changes in TMD patients.Saliva of 50 TMD patients (diagnosed by validated diagnostic criteria and MRI) and 50 controls will be collected. OS markers will be assessed by ELISA with spectrophotometric detection and by spectrophotometric reagent kits. OP levels will be measured by HPLC-MS/MS method, developed by team members. The electrochemiluminescence immunoassay ECLIA will be used for measuring SC.TMD patients will be randomized in 2 treatment groups (1:stabilization splint + placebo pills; 2:placebo splint + 1g of vitamin C). Measurements will be repeated after 3 and 6 months of treatment. Monitoring of OP, OS markers and SC during that period will, in relation to TMD symptoms changes, further elucidate underlying proposed mechanism.Novel approach to understanding neuroendocrine mechanisms in TMD and use of saliva as non-invasively available biofluid represent significant advances.]]></summary_en></project><project>
<id>2877</id><title_hr><![CDATA[Utjecaj magnetske anizotropije na kvantne spinske sustave]]></title_hr><title_en><![CDATA[Influence of Magnetic Anisotropy on Quantum Spin Systems]]></title_en><user_id>11197</user_id><user_firstLast_name>Mirta Herak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2014-09</proposal_call><code>UIP-2014-09-9775</code><acronim><![CDATA[IMAQSS]]></acronim><duration>01.06.2015 - 15.09.2018</duration><status>Završio</status><financ_value>99.542,11 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, Kemija, </scie_field_hr><scie_field_en>Physics, Chemistry, </scie_field_en><institution_hr><![CDATA[Institut za fiziku]]></institution_hr><institution_en><![CDATA[Institute of Physics in Zagreb]]></institution_en><team_members_id>2647, 12486, 21233, 2873, </team_members_id><team_members_names><![CDATA[Dijana Žilić, Ivana Levatić, Martina Dragičević, Nikolina Novosel, ]]></team_members_names><keywords_hr><![CDATA[Kvantni spinski sustavi, niskodimenzionalni magneti, magnetska anizotropija, torque magnetometrija, elektronska spinska rezonancija]]></keywords_hr><keywords_en><![CDATA[Quantum spin systems, low-dimensional magnets, magnetic anisotropy, torque magnetometry, esr spectroscopy]]></keywords_en><summary_hr><![CDATA[Proučavanje magnetskih materijala donijelo nam je razumijevanje mnogih fizikalnih pojava te doprinijelo razvoju novih tehnologija. Magnetizam je kvantna pojava koja dolazi od interakcija superizmjene među magnetskim momentima u materijalu. Razumijevanje utjecaja tih interakcija na formiranje materijala sa specifičnim magnetskim svojstvima jedan je od glavnih problema u znanosti o materijalima. U niskodimenzionalnim kvantnim spinskim sustavima interakcije među spinovima su često opisane izotropnim Heisenbergovim hamiltonijanom. Eksperimentalni rezultati ukazuju na važnost slabih anizotropnih interakcija te zahtijevaju nova teorijska istraživanja. Te interakcije induciraju nove zanimljive pojave s velikim potencijalom za primjenu te je nalaženje novih metoda osjetljivih na njihovu detekciju od velike važnosti.Cilj ovog projekta je eksperimentalno istraživanje utjecaja magnetske anizotropije na odabrane kvantne spinske sustave kombinacijom dviju iznimno osjetljivih tehnika: torque magnetometrije i spektroskopske metode elektronske spinske rezonancije (ESR). Istraživat ćemo uzorke čiji magnetizam dolazi od spinova S=1/2, a koji se mogu klasificirati kao male spinske nakupine, kvazi-jednodimenzionalni Heisenbergovi antiferomagneti i/ili magnetoelektrici. Kombinacija spomenutih tehnika dat će novu metodologiju za istraživanje utjecaja magnetske anizotropije na kvantne spinske sustave i druge magnetske materijale te doprinijeti razumijevanju pojava induciranih magnetskom anizotropijom.U ovom projektu ostvarit će se suradnja između fizičara i kemičara sa svrhom sinteze novih visokokvalitetnih magnetskih materijala. Istraživanja će biti fokusirana na te materijale i na uzorke dobivene iz inozemnih ekspertnih laboratorija. Glavni cilj ovog projekta je formiranje nove istraživačke grupe s ekspertizom u istraživanju pojava induciranih anizotropijom u novim magnetskim materijalima.]]></summary_hr><summary_en><![CDATA[Study of magnetic materials provides us with understanding many of physical phenomena and continues to provide us with new technologies. Magnetism is a quantum phenomenon emerging from the superexchange interactions between magnetic moments in the material. Understanding how these interactions bring forth a material with specific magnetic properties is one of the key questions in materials science. In low-dimensional quantum spin systems the interactions between the spins are often described by the isotropic Heisenberg Hamiltonian. The importance of weak anisotropic interactions emerges from experiments and requires new theoretical treatments. These interactions are found to induce new interesting phenomena with great potential for applications in emerging technologies. Exploiting new methods sensitive to these interactions is thus crucial. Aim of this project is to experimentally investigate the influence of magnetic anisotropy on chosen quantum spin systems by combining two highly sensitive techniques: torque magnetometry and electron spin resonance (ESR) spectroscopy. Our study is focused on samples with magnetism coming from electron spin S=1/2, which can be classified as weakly interacting small spin clusters, quasi one-dimensional Heisenberg antiferromagnets and/or magnetoelectrics. The combination of mentioned techniques allows a new methodology for investigation of the influence of magnetic anisotropy on quantum spin systems and other magnetic materials and will provide important input in understanding of anisotropy induced phenomena.Within this project a collaboration between physicists and a chemist will be established with the purpose of synthesising new high-quality magnetic materials. Our study will focus on these materials, and on samples synthesized in expert laboratories abroad. The main aim of this project is to form a new independent research group highly qualified to investigate the anisotropy induced phenomena in new promising magnetic materials.]]></summary_en></project><project>
<id>2881</id><title_hr><![CDATA[Istraživanje bioaktivnih spojeva iz dalmatinskog bilja: njihov antioksidacijski karakter i  utjecaj na enzimsku inhibiciju i zdravlje]]></title_hr><title_en><![CDATA[Investigation of bioactive compounds from Dalmatian plants: their antioxidant, enzyme inhibition and health properties]]></title_en><user_id>11165</user_id><user_firstLast_name>Mladen Miloš</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-6897</code><acronim><![CDATA[BioActCom]]></acronim><duration>01.09.2015 - 31.08.2019</duration><status>Završio</status><financ_value>104.851,02 eur</financ_value><scie_area_hr>Prirodne znanosti, Biotehničke znanosti, Biomedicina i zdravstvo, </scie_area_hr><scie_area_en>Natural sciences, Biotechnical sciences, Biomedicine and health sciences, </scie_area_en><scie_field_hr>Kemija, Biologija, Farmacija, Prehrambena tehnologija, Nutricionizam, </scie_field_hr><scie_field_en>Chemistry, Biology, Pharmaceutical sciences, Food technology, Nutrition, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Kemijsko-tehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Chemistry and Technology]]></institution_en><team_members_id>5297, 11213, 4634, 1227, 250, 100, 3823, 11269, 11267, 11168, 11169, </team_members_id><team_members_names><![CDATA[Višnja Katalinić, Olivera Politeo, Mila Radan, Vida Šimat, Ivana Generalić Mekinić, Franko Burčul, Danijela Skroza, Ivana Carev, Maja Marasović, Safija Herenda, Jelena Ostojić, ]]></team_members_names><keywords_hr><![CDATA[bioaktivni spojevi, inhibitori enzima, antioksidansi, oksidacijski stres, dalmatinsko bilje]]></keywords_hr><keywords_en><![CDATA[bioactive compounds, enzyme inhibitors, antioxidants, oxidative stress, Dalmatian plants]]></keywords_en><summary_hr><![CDATA[ Reaktivni kisikovi spojevi (ROS), koji u  živim stanicama  nastaju tijekom prirodnih procesa aerobnog metabolizma, mogu znatno oštetiti vitalne makromolekule i promijeniti njihove  funkcije. Kao rezultat oksidacijskog stresa i inhibicije pojedinih enzima, povećana je mogućnost nastanka kroničnih bolesti kao što su rak, ateroskleroza, neurodegenerativne bolesti, dijabetes itd.  U živim organizmima razvijen je visoko sofisticirani i složeni sustav antioksidacijske zaštite, koji interaktivno i sinergijski neutralizira loš utjecaj ROS spojeva. Predloženi projekt treba skrenuti pozornost na činjenicu da dalmatinsko samoniklo bilje obiluje  biološki aktivnim spojevima koje bi se moglo koristiti za prevenciju oksidacijskog stresa i liječenje različitih oboljenja. Identifikacija novih antioksidansa i inhibitora enzimskih aktivnosti  mogla naći primjenu u prehrambenoj i farmaceutskoj industriji za pripremu zdrave hrane i prirodnih lijekova za sprječavanje štetnih oksidacijskih procesa.]]></summary_hr><summary_en><![CDATA[Reactive oxygen species (ROS), which are generated during the natural process of aerobic metabolism in living cells, can significantly damage their vital macromolecules and change functions. As a result of oxidative stress and inhibition of certain enzyme activities, it has increased the possibility of occurrence of chronic diseases such as cancers, atherosclerosis,  neurodegenerative diseases, diabetes, etc.  To protect the cells and organs of the body against ROS, human organisms have evolved a highly sophisticated and complex antioxidant protection system which involves a variety of components that interactively and synergistically could neutralize their bad influence.  Identification of new antioxidant and inhibitor of the enzyme activities from Dalmatian plants could find application in the food and pharmaceutical industry for preparing healthy foods and natural remedies to prevent harmful oxidation processes.]]></summary_en></project><project>
<id>2886</id><title_hr><![CDATA[Molekularna, epidemiolološka i klinička obilježja zaraze HIV-om u Hrvatskoj]]></title_hr><title_en><![CDATA[Molecular, epidemiological and clinical features of HIV infection in Croatia]]></title_en><user_id>1084</user_id><user_firstLast_name>Josip Begovac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-4461</code><acronim><![CDATA[MEKHH/MECHC]]></acronim><duration>01.10.2015 - 31.12.2019</duration><status>Završio</status><financ_value>126.750,28 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Kliničke medicinske znanosti, Temeljne medicinske znanosti, Javno zdravstvo i zdravstvena zaštita, </scie_field_hr><scie_field_en>Clinical sciences, Basic Medical Sciences, Public health and health services, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>1082, 12514, 1093, 4080, 12478, 1161, 3952, 3951, </team_members_id><team_members_names><![CDATA[Klaudija Višković, George Rutherford, Šime  Zekan, Snježana Židovec Lepej, Ana Planinić, MARTA PEROVIĆ MIHANOVIĆ, Lana Gorenec, Ivana Grgić, ]]></team_members_names><keywords_hr><![CDATA[HIV, AIDS, supklinička ateroskleroza, podtipovi HIV-a, rezistancija, antiretrovirusni lijekovi, preživljenje]]></keywords_hr><keywords_en><![CDATA[HIV. AIDS, subclinical atherosclerosis, HIV subtypes, resistance, antiretrovirals, survival]]></keywords_en><summary_hr><![CDATA[Hrvatska ima centraliziranu skrb za osobe zaražene HIV-om, svi bolesnici se liječe u Klinici za infektivne bolesti u Zagrebu. Opći cilj projekta je nastaviti dugotrajno prikupljati kliničke, molekularne, laboratorijske i terapijske podatke u skupini bolesnika zaraženih HIV-om iz Hrvatske te: (1) procijeniti čimbenike u svezi s kliničkim, imunološkim i virusološkim tijekom zaraze HIV-om i (2) nastaviti razvijati sustav molekularnog nadzora uz definiranje promejna koje se tijekom vremena događaju u zarazi HIV-om u Hrvatskoj. Opći istraživanja uključuje prospektivno istraživanje demografskih, kliničkih, terapijskih, virusoloških i laboratorijskih podatke u osoba zaraženih HIV-om u Hrvatskoj, u svrhu određivanja dugotrajnog virusološkog, imunološkog i kliničkog ishoda kao i trendove u molekularnoj epidemiologiji zaraze HIV-om. Specifični ciljevi istraživanja uključuju također: procjenu nazočnosti supkliničke ateroskleroze u bolesnika zaraženih HIV-om koji primaju ART te ispitanika koji nisu zaraženi HIV-om, analizirati učinak prehtrambenih navika, posebno mediteranske prehrane na supkliničku aterosklerozu, odrediti učestalost subtipova HIV-a u novodijagnosticiranih bolesnika koji su se uključili u kliničku skrb u razdoblju od 2014 do 2017.g., analizirati transmisijske klastere subtipa B i non-B subtipova HIV-a, te odrediti prevalenciju i obrasce mutacija povezanih s primarnom rezistencijom HIV-a na lijekove. U istraživanje će se uključiti sve osobe koje se liječe u KIB, a dale su pismenu privolu za istraživanje. Uključiti će se osobe koje su bile u skrbi u razdoblju 1997 do 2017. Procjenjuje se da će ukupno 700-800 osoba biti uključeno u analize. Očekujemo da će rezultati ovog projekta doprinijeti unaprjeđivanju kvalitete skrbi bolesnika zaraženih HIV-om kao i razvoju strategija uspješnije prevencije zaraze HIV-om.]]></summary_hr><summary_en><![CDATA[Croatia as a centralized system of care and all HIV infected persons are treated at the University Hospital of Infectious Diseases (UHID) in Zagreb. ln general terms, the objective of the project s to continue a long-term, prospective collection of biomolecular, clinical, laboratory and therapeutic data on a cohort of HIV infected patients from Croatia in order to (1) assess the factors associated with the clinical, immunological and virological course of HIV infection and (2) continue to provide and develop a molecular surveillance system to describe temporal changes of HIV-infection in in Croatia. The primary aim is to determine the long-term virological, immunological and clinical outcome as well as trends in the molecular epidemiology of HIV infection. We will also specifically address issues such as: subclinical atherosclerosis in both HIV-infected patients taking ART and non-HIV-infected participants; the influence of food habits, specifically adherence to the Mediterranean diet on subclinical atherosclerosis; the frequency of HIV subtypes among newly-diagnosed patients entering clinical care in the period 2014-2017; transmission clusters of B and non-B subtypes; prevalence and patterns of transmitted drug resistance (TDR) to different classes of antiretroviral drug resistance in newly-diagnosed HIV-infected persons in the period 2014-2017 with the impact of transmission clusters on the prevalence of TDR. The study population will include all patients in care at UHID who provided written consent. Patient eligible for analysis were or will be seen in care at UHID from 1997 to 2017. It is estimated that a total of about 700-800 will be included into the analyses. The results of this project are expected to significantly contribute to the improvement of HIV clinical care as well as to the development of improved strategies for prevention of HIV infection.]]></summary_en></project><project>
<id>2887</id><title_hr><![CDATA[Životne strategije fitoplanktona u sjevernom Jadranu]]></title_hr><title_en><![CDATA[Phytoplankton lifestrategies in the northern Adriatic]]></title_en><user_id>3476</user_id><user_firstLast_name>Martin Pfannkuchen</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2014-09</proposal_call><code>UIP-2014-09-6563</code><acronim><![CDATA[P-limit]]></acronim><duration>30.09.2015 - 29.09.2018</duration><status>Završio</status><financ_value>132.709,54 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, Kemija, </scie_field_hr><scie_field_en>Biology, Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>465, 547, 4424, 5284, 81, 543, 390, </team_members_id><team_members_names><![CDATA[Ingrid Ivančić, Emina Pustijanac, Daniela Maric Pfannkuchen, Grozdan Kušpilić, Blaženka Gašparović, Mirta Smodlaka Tanković, Ana Baričević, ]]></team_members_names><keywords_hr><![CDATA[Fitoplankton, aktivnost alkalina fosfatasa, sjeverni jadran, fosfat limitacija, životna strategija]]></keywords_hr><keywords_en><![CDATA[Phytoplankton, alkaline phosphatase activity, northern Adriatic, phosphate limitation, life strategy]]></keywords_en><summary_hr><![CDATA[U plitkim morima jednostanični organizmi su ključni za funkcioniranje ekosustava. Budući da je rast tih organizama uglavnom ograničen dostupnošću anorganskog dušika i fosfora, indukcijom ekstracelularnih enzima oni mogu koristiti organsku tvar kao izvor tih elementa. Mjerenja ukupne enzimatske aktivnosti su dobar pokazatelj metaboličke aktivnosti planktnonskih zajednica. Međutim da bi se shvatilo funkcioniranje ekosustava u cijelini, te kako planktonske zajednice reagiraju na prirodne promjene i antropogeni pritisak potrebno je poznavati odgovore na razini pojedine vrste unutar zajednice. Ta saznanja bi značajno doprinijela razumijevanju kako pojedine vrste utječu na funkcioniranje zajednice. Do sada takva detaljna istraživanja nisu sistematski provedena. Zbog neuravnoteženog slatkovodnog unosa hranjivih soli područje je uglavnom P limitirano. Stoga fitoplankton na tom području mora razviti strategije snalaženja da bi uspješno kompetirao za za taj element. Naša preliminarna istraživanja su pokazala da mikrofitoplankton može razviti čitav niz mehanizama prilagodbe da bi uspijevao u izrazito promjenjivoj dostupnosti hranjivih soli i uglavnom P limitiranim uvjetima. Cilj ovog projekta bio bi shvatiti metabolizam na nivou vrste te istražiti strategije koje omogućavaju najvažnijim vrstama da uspjevaju u kompleksnim uvjetima okoline. SJ je podesan za takva istraživanja jer na tom području postoje dugoročni podaci o oceanografskim i trofičkim uvjetima. Istraživanja bi bila usredotočena na mikrofitoplankton budući da je po biomasi to dominantna grupa fitoplanktonske zajednice. Osim toga njegovo je taksonomsko određivanje dobro uhodano, a metode dostupne našoj istraživačkoj grupi. Skup modernih i klasičnih metoda razvijenih i kombiniranih u ovom projektu značajno će doprinijeti napretku u ekološkim istraživanjima, kao i u klasičnom sustavu praćenja ekosustava.]]></summary_hr><summary_en><![CDATA[Unicellular organisms are the driving forces in shallow pelagic ecosystem functioning. Measurement of bulk enzymatic activity in water samples is a good proxy for the metabolic activity of planktonic communities. However the basis to understand how such ecosystems function and how planktonic communities react on natural and anthropogenic changes is detailed knowledge on how each functional unit (species) of the plankton community functions. Such knowledge will allow to understand how each component (species) contributes to the bulk community functioning and more important how changes in ecological conditions will change the community structure and subsequently the ecosystems functioning. So far such detailed analyses are not systematically undertaken. In this project we will achieve species resolution in metabolic analysis and understand the respective lifestrategies that make the most prominent phytoplankton species successful competitors in the P-limited system of the northern Adriatic (NA). We chose the NA as a well investigated and understood marine shallow ecosystem. This project investigates the metabolic adaptations to P-limitation as they are the most prominent adaptation in the NA. We will concentrate our investigations on microphytoplankton as it is taxonomically well defined and accesible to our research teams expertise and range of methods and as our preliminary results show the microphytoplankton to be the dominating component of the plankton community in the NA. Our preliminary research did uncover a variety of mechanisms that allow microphytoplankton to thrive in steep ecological gradients and generally P-limited conditions. A combination of modern and classical methodologies (ecology, oceanography, cell biology, advanced microscopy, taxonomy, phylogenetic analysis, molecular biology, biochemistry) as well as a comprehensive ecological (long term) database for the region will allow us to uncover the complex set of microphytoplankton lifestrategies.]]></summary_en></project><project>
<id>2891</id><title_hr><![CDATA[Sklerokronologija kao alat za otkrivanje dugoročnih okolišnih promjena u Jadranu]]></title_hr><title_en><![CDATA[Sclerochronology as a tool for detecting long-term Adriatic environmental changes]]></title_en><user_id>667</user_id><user_firstLast_name>Melita Peharda Uljević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-5747</code><acronim><![CDATA[SCOOL]]></acronim><duration>01.06.2015 - 31.05.2019</duration><status>Završio</status><financ_value>116.815,98 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, Geologija, Kemija, Geofizika, </scie_field_hr><scie_field_en>Biology, Geology, Chemistry, Geophysics, </scie_field_en><institution_hr><![CDATA[Institut za oceanografiju i ribarstvo]]></institution_hr><institution_en><![CDATA[Institute of Oceanography and Fisheries]]></institution_en><team_members_id>195, 829, 670, 5215, 3031, 3525, 2530, 7600, 5837, 25078, </team_members_id><team_members_names><![CDATA[Ivica Vilibić, Jadranka Šepić, Daria Ezgeta Balić, Krešimir Markulin, Žarko Kovač, Hrvoje Mihanović, Sanja Puljas, Miroslav Gacic, Ivan Župan, Hana Uvanović, ]]></team_members_names><keywords_hr><![CDATA[klimatske promjene, sklerokronologija, Bivalvia, dinamička svojstva mora, ekologija mora]]></keywords_hr><keywords_en><![CDATA[climate change, sclerochronology, Bivalvia, ocean dynamics, marine ecology]]></keywords_en><summary_hr><![CDATA[Klimatske promjene predstavljaju rastući problem sa aspekta okoliša, znanosti kao gospodarstva. Iako smo svjesni određenih promjena koje se događaju naše poznavanje njihovog porijekla i posljedica još uvijek je jako ograničeno. Dugoročni nizovi podataka su ključ za razumijevanje takvih promjena i čvrste strukture morskih organizama, uključujući ljušture školjkaša, predstavljaju važan arhiv podataka o okoliš koji potencionalno seže dekade ili čak stoljeća u prošlost. Sklerokonologija je novo interdisciplinarno područje znanosti koje omogućava dobivanje podataka o morskom okolišu iz strukturalnih elementa školjkaša i njihovog geokemijskog sastava. Takvi podatci su od velikog značaja za razumijevanje procesa na nivou ekosustava u morskom okolišu kao i njihovih odgovora na klimatske promjene.Motivacija i cilj ovog projekta jest je da primjenom recentnih sklerokronoloških metoda izgradimo kronologije za tri relativno dugo živuće vrste školjkaša (životni vijek oko pola stoljeća), koje obitavaju u istočnom Jadranu. Ciljane vrste uključuju školjkaše Glycymeris glycymeris, G. bimaculata i Callista chione. Kronologije će biti paralelno analizirane sa dugoročnim in situ podatcima kao i modeliranjem klimatoloških i oceanografskih parametara, sa ciljem kvantificiranje utjecaja okoliša na rast školjkaša. Nadalje, oceanografski podatci će se primijeniti za opisivanje dinamike oceana i procesa koji se odvijaju na višegodišnjim i dekadskim vremenskim skalama u Jadranko-Jonskom bazenu i koji su važni za rast svih morskih organizama. Projekt se razvija iz dvije nezavisne teme, sklerokronologije i fizičke oceanografije (znanosti o okolišu), koje se spajaju na interdisciplinarni način u kasnijim fazama implementacije projekta. Stoga je predloženi projekt izuzetno interdisciplinaran, dok je projektni tim transnacionalan.            ]]></summary_hr><summary_en><![CDATA[Climate change is a growing environmental, scientific as well as economic issue. However, although we are aware of certain changes our understanding of their origin and consequences is still very limited. Long-term data series are a key to this understanding and hard structures of marine organisms, including bivalve shells, present an important archive of environmental data potentially extending decades or even centuries into the past. Sclerochronology is an emerging interdisciplinary field that enables obtaining of marine environmental data from bivalve shell structural elements as well as their geochemical composition. These data are of great importance for understanding of the marine ecosystem-level process and responses to climate variability.Our motivation for the project is, by applying modern sclerochronological methods, to construct chronologies for three relatively long-lived bivalve species (longevity about half-century), living in the eastern Adriatic Sea. Target organisms include dog cockles Glycymeris glycymeris and G. bimaculata, and a smooth clam Callista chione. These chronologies will be analysed in parallel with long-term in situ and climate model oceanographic data, in order to quantify environmental effect on the bivalve growth. Further on, the oceanographic data will be used for portraying of ocean dynamics and processes that occur over interannual and decadal timescales in the Adriatic-Ionian basin and are important for growth of all marine organisms. The project will grow from two relatively independent topics, sclerochronology and ocean physical (environmental) sciences, merging them in an interdisciplinary manner in the later stage of the project execution. The project is highly interdisciplinary, while the project team is transnational. ]]></summary_en></project><project>
<id>2892</id><title_hr><![CDATA[Razvoj metodološkog okvira za rješavanje strateških problema u  visokom obrazovanju – primjer implementacije otvorenog učenja i učenja na daljinu]]></title_hr><title_en><![CDATA[Development of methodology and tools for multicriteria decision making in HE- case study of open and distant learning implementation]]></title_en><user_id>12508</user_id><user_firstLast_name>Blazenka Divjak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-7854</code><acronim><![CDATA[HigherDecision]]></acronim><duration>01.06.2015 - 31.05.2019</duration><status>Završio</status><financ_value>77.427,50 eur</financ_value><scie_area_hr>Društvene znanosti, Prirodne znanosti, Tehničke znanosti, </scie_area_hr><scie_area_en>Social sciences, Natural sciences, Technological sciences, </scie_area_en><scie_field_hr>Informacijske znanosti, Matematika, Računarstvo, </scie_field_hr><scie_field_en>Information sciences, Mathematics, Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet organizacije i informatike]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Organization and Informatics]]></institution_en><team_members_id>12509, 12516, 12523, 5642, 12531, 12521, 12527, 12583, 12591, 121, 7751, 13731, 12590, 6087, 21076, 25090, </team_members_id><team_members_names><![CDATA[Nina Begičević Ređep, Marcel Maretić, Katarina Pažur Aničić, Ivanka Đeri, Vjeran Strahonja, Nikola Kadoić, Sanjana  Buć, Valentina Đurek, Tihomir Hunjak, Maja Ćukušić, Andrina Granić, Sandra Kučina Softić, Valentina Kirinić, Ana Ćorić Samardžija, Antonia Bralic, Mišo Džeko, ]]></team_members_names><keywords_hr><![CDATA[odlučivanje, e-učenje, otvoreno učenje i učenje na daljinu, visoko obrazovanje, e-spremnost, procjena rizika, kauzalnost, AHP]]></keywords_hr><keywords_en><![CDATA[decision making, e-learning, open and distant learning, higher education, e-readiness, risk assessment, portfolio, causality, AHP]]></keywords_en><summary_hr><![CDATA[Visoko obrazovanje (VO) ima ključnu ulogu u razvoju ljudskih potencijala te u gospodarskom i društvenom razvoju. Stoga, donošenje odluka i praćenje njihove primjene u visokom obrazovanju postaje prvorazredno istraživačko i razvojno pitanje. Primarni istraživački cilj ovog projekta je razvoj cjelovite metodologije donošenja strateške odluke i praćenja njezine provedbe u VO. U svijetu se broj korisnika online edukacije rapidno povećava, a postoje i brojna izvješća koja govore o digitalnoj spremnosti te upotrebi informacijsko-komunikacijske tehnologije (IKT) u VO. Dvije osnovne komponente projekta:1. Razvoj  metodološkog okvira donošenja strateških odluka u VO i praćenje njihove provedbe. 2. Primjena, prilagodba i provjera dane metodologije na primjeru implementacije odluke o uvođenju otvorenog učenja i učenja na daljinu.Istraživanje je interdisciplinarno i povezuje društveno područje (višekriterijsko odlučivanje, IKT, strateško planiranje) i matematiku (matematičko modeliranje, kvantitativne metode u odlučivanju, kauzalne modele i teoriju grafova). Istraživanje rješavanja strateških problema provodimo kroz ciklus strateškog odlučivanja u četiri faze: (1) prepoznavanje i istraživanje problema - identificirat će se i unaprijediti metodologije kao što su procjena spremnosti i difuzija inovacija.(2) razvoj metodologije odlučivanja i donošenja odluke -  istražit će se primjena i unapređenje metodologije višekriterijske analize odluka u VO.(3) provedba i praćenje strateške odluke - identificirati će se ključni faktori koji utječu na uspješnost provedbe strateške odluke i njihove međuzavisnosti i razviti model za mjerenje zrelosti i uspješnosti implementacije strateških odluka u VO.(4) evaluacija učinaka provedbe odluke -  istražit će se mogući pristupi, a posebno evaluacija upotrebom strukturalne teorije kauzalnosti. ]]></summary_hr><summary_en><![CDATA[Higher education’s (HE) key mission is to develop human potential with beneficial effects for the social and economic development. HE as a system, along with HE institutions, must be innovative and strategically managed to be able to fulfill their mission. Therefore, the decision making accompanied by evaluation of its implementation in higher education is an issue of highest priority. Primary goal of this research proposal is to develop a complete methodology for strategic decision making and the monitoring of its implementation in HE. The enrollment rate within online education has skyrocketed worldwide and there are a number of reports on e-readiness and ICT use in HE. Two basic components of the project:1. Development of methodological framework for strategic decision making in HE and monitoring of its implementation. 2. Application, adjustment and evaluation of the methodology on the example of decision implementation on e-learning and distance learning.This is an interdisciplinary project connecting Social Sciences (ICT, multicriteria decision making, strategic planning) and Mathematics (mathematical modeling, quantitative methods in decision making, structural causal models and graph theory).The research is structured as a cycle of strategic decision making with four phases:(1) Intelligence - problem identification and research, advancement of methodologies such as readiness assessment, diffusion of innovation etc.(2) Design of methodology -  design of decision making methodology and decision making, improvement of multicriteria decision analysis in HE.(3) Implementation and monitoring - research and identification of key factors that determine effectiveness of strategic decision, their correlation, design of measuring model for maturity and effectiveness of strategic decision implementation in HE(4) Evaluation - survey possible approaches and evaluation by application of J. Pearl’s structural causal models for identification of effects of strategic decision.]]></summary_en></project><project>
<id>2899</id><title_hr><![CDATA[Procesi u morskoj mikrobnoj hranidbenoj mreži u perspektivi globalnog zatopljenja]]></title_hr><title_en><![CDATA[Marine microbial food web processes in global warming perspective]]></title_en><user_id>172</user_id><user_firstLast_name>Mladen Šolić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-4143</code><acronim><![CDATA[MICROGLOB]]></acronim><duration>01.11.2015 - 31.10.2019</duration><status>Završio</status><financ_value>115.468,84 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, Kemija, </scie_field_hr><scie_field_en>Biology, Chemistry, </scie_field_en><institution_hr><![CDATA[Institut za oceanografiju i ribarstvo]]></institution_hr><institution_en><![CDATA[Institute of Oceanography and Fisheries]]></institution_en><team_members_id>203, 459, 531, 204, 437, 407, 207, </team_members_id><team_members_names><![CDATA[STEFANIJA  ŠESTANOVIĆ, Nada  Krstulović, Ana Vrdoljak, Slaven Jozić, Danijela Šantić, Marin Ordulj, Natalia Bojanić, ]]></team_members_names><keywords_hr><![CDATA[mikrobna zajednica, mikrobna hranidbena mreža, grazing, protok ugljika, globalno zatopljenje, fosfor, bakterijska respiracija, bakterijska efikasnost ]]></keywords_hr><keywords_en><![CDATA[microbial community, microbial food web, grazing, carbon flux, global warming, phosphorus, bacterial respiration, bacterial growth efficiency]]></keywords_en><summary_hr><![CDATA[Mikrobna zajednica uključuje jednostanične organizme koji pokrivaju široki veličinski raspon (od 0.02 do 200 µm) i s obzirom na trofički status uključuju autotrofne, heterotrofne i miksotrofne organizme. Ova je zajednica odgovorna za više od 50% primarne proizvodnje i proizvodnje kisika na Zemlji i ključni je pokretač biogeokemijskih ciklusa koji su ključni za ukupnu produktivnost mora. S obzirom na te značajke, vrlo je važno znati kako ova zajednica odgovara na poremećaje u morskom okolišu. Tijekom ovog projekta istraživat će se struktura mikrobne zajednice i mikrobna hranidbena mreža, te njeni kvantitativni, kvalitativni (strukturni) i funkcionalni odgovori na prirodne i antropogene promjene u morskom okolišu, te će se pokušati detektirati potencijalni pokazatelji tih promjena. U fokusu projekta biti će traženje odgovora na pitanje koje promjene u strukturi i funkcioniranju morske mikrobne hranidbene mreže u uvjetima globalnog zatopljenja možemo očekivati, te kako se ti utjecaji manifestiraju s obzirom na trofički status područja. Pri tome će se posebice istraživati uloga fosfora s obzirom da je Jadransko more općenito fosforom limitirano područje. Istraživanja će uključivati mjesečna terenska istraživanja koja će obuhvatiti estuarska, priobalna i otvorena područja mora, kao i laboratorijske i in situ eksperimente. Aktivnosti na Projektu odvijat će se kroz tri glavne teme: (1) Struktura mikrobne hranidbene mreže koja će biti istraživana na prostornoj (različiti morski okoliši), trofičkoj (trofički gradijent) i vremenskoj (mjesečna i međugodišnja) skali, te moguće temperaturnoj i salinitetnoj skali (usporedna analiza između prirodnih sustava s različitim temperaturnim i salinitetnim režimom), (2) Protok bakterijskog ugljika, koji uključuje eksperimente grazinga, te protok zgljika kroz mikrobnu hranidbenu mrežu, te (3) Eksperimentalni utjecaj porasta temperature i koncentracije fosfora na strukturu i funkcije mikrobne hranidbene mreže.]]></summary_hr><summary_en><![CDATA[Microbial community includes single-celled organisms that cover a wide size range (from 0.02 to 200 µm) and includes autotrophic, heterotrophic and mixotrophic organisms. This community is responsible for more than 50% of the primary production and oxygen production on Earth and are essential driving forces for biogeochemical cycles with established impacts on overall marine productivity. With respect to these properties it is very important to know how the community responds to disturbances and environmental changes. This project will study the structure of microbial community and microbial food web, as well as its quantitative, qualitative (structural) and functional responses to natural and man-induced changes in marine environment and will try to detect potential indicators of these changes. The main focus of the project will be to study what changes in the structure and functioning of marine microbial food web in terms of global warming we can expect, and how these influences are manifested with regard to the trophic status of the area. The role of phosphorus will be particularly studied with regard to the fact that Adriatic Sea is generally phosphorus limited area. Research will consist of monthly field sampling that will include estuary, coastal and open sea areas, as well as laboratory and in situ experiments. Project activities will be carried out through three main topics: (1) Structure of microbial food web on spatial (different marine environments), trophic (trophic gradient) and temporal (intra- and inter-annual) scales, and possibly temperature and salinity scales (cross comparisons between natural systems under different temperature and salinity regimes); (2) Bacterial carbon flux which include grazing experiments and study of bacterial carbon flux through the microbial food web; and (3) Experimental impact of temperature increase and phosphate additions on microbial community structure and carbon flux toward the higher trophic levels.]]></summary_en></project><project>
<id>2904</id><title_hr><![CDATA[Razvoj sintetskih kimera vinove loze (Vitis vinifera L.)]]></title_hr><title_en><![CDATA[Development of grapevine (Vitis vinifera L.) synthetic chimeras ]]></title_en><user_id>11198</user_id><user_firstLast_name>Darko  Preiner</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2014-09</proposal_call><code>UIP-2014-09-8110</code><acronim><![CDATA[ChimeraVitis]]></acronim><duration>16.06.2015 - 14.09.2018</duration><status>Završio</status><financ_value>37.604,80 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Biotehnologija, Poljoprivreda, </scie_field_hr><scie_field_en>Biotechnology, Agriculture, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Agronomski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Agriculture]]></institution_en><team_members_id>13517, 13508, 13506, 4418, 13543, 13509, 3132, 24336, </team_members_id><team_members_names><![CDATA[Anita Mihovilović Bošnjak, Željko  Andabaka, Domagoj  Stupić, Silvio  Šimon, Jasminka Karoglan Kontić, Zvjezdana Marković, Edi Maletić, Iva Šikuten, ]]></team_members_names><keywords_hr><![CDATA[vinova loza, oplemenjivanje bilja, sintetske kimere, kultura biljnog tkiva, mikrosatelitski markeri]]></keywords_hr><keywords_en><![CDATA[grapevine, plant breeding, synthetic chimeras, plant tissue culture, microsatelite marc]]></keywords_en><summary_hr><![CDATA[Biljne periklinalne kimere imaju tkiva najmanje dviju različitih genotipova u različitim slojevima apikalnog meristema što ima znatan utjecaj na svojstva ovakvih biljaka. Mnoge sorte i klonovi vinove loze koje su danas značajne u proizvodnji su periklinalne kimere koje su nastale spontano zbog mutacija u jednom od slojeva apikalnog meristema (Pinot crni, sivi i meunier).  Za razliku od kimera koje su nastale mutacijama postoje i tzv. međuvrsne ili međusortne kimere koje su sastavljene od dvaju različitih genotipova koji pripadaju različitim vrstama ili sortama. Ovakve kimere mogu nastati spontano iz spojnog mjestu prilikom cijepljenja, a mogu se  ciljano stvoriti što je osnovni preduvjet za razvoj kimeralnog oplemenjivanja, kao izuzetno zanimljive, ali zapostavljene metode oplemenjivanja bilja. U predloženom projektu istraživati će se  mogućnosti dobivanja i detekcije sintetskih kimera različitih sorata vinove loze, ali i sintetskih kimera sorata vinove loze i američkih vrsta (otporne na filokseru, plamenjaću i pepelnicu). U početnoj fazi projekta istraživati će se uvjeti za uspješnu in vitro organogenezu 20 različitih genotipova (10 sorata, 5 podloga i 5 vrsta iz roda Vitis.). U slijedećoj fazi odabrati će se genotipovi koji imaju slične zahtjeve prema uvjetima  za organogenezu te će se ona nastojati inducirati iz miješanog tkiva iz najmanje triju parova odabranih genotipova. Nakon organogeneze detektirati će se biljke sa kimeralnim statusom bilo koje vrste. Identifikacija i dokazivanje kimera provesti će se kombinacijom fenotipskih markera (npr. boja epiderme) i analizom genotipa primjenom mikrosatelitskih (SSR) markera. Pozicije genotipova u slojevima staničja periklinalnih kimera provest će se genetičkim analizom (SSR) adventivnog korijena. Rezultati ovog projekta o mogućnostima razvoja sintetskih međusortnih i međuvrsnih kimera uvelike će utjecati na daljnji razvoj kimeralnog oplemenjivanja kod vinove loze.]]></summary_hr><summary_en><![CDATA[Plant periclinal chimeras have tissues of at least two different genotypes in different layers of apical meristem and this has significant influence on properties of this plants. Many grapevine cultivars and clones used in production today are actually periclinal chimeras formed by spontaneous mutation of cells in certain layer of apical meristem (i.e. Pinot noir, gris and meunier).  Many intervarietal and interspecific chimeras are also detected which are formed from two different genotypes (cultivars or species). This type of chimeras can arise spontaneously from graft tissue, but this process can also be controlled.  This is the base for development of chimeral breeding, as a very interesting but underutilized plant breeding method. In project proposal research on the possibilities of in vitro methods of development and detection of grapevine intravarietal synthetic chimeras will be performed, but also chimeras of grapevine and other Vitis species (with resistance to phyloxera, downy and powdery mildew). In the first stage of the project research on conditions for in vitro organogenesis of 20 different genotypes (10 grapevine cultivars, 5 rootstocks and 5 genotypes of  Vitis species). In next stage of the project genotypes with similar requirements for organogenesis conditions will be chosen, and organogenesis will be induced from mixed tissue of at least three pairs of genotypes. After organogenesis, detection of all chimeral plants will be performed. Identification and confirmation of chimeras will be performed using combination of phenotypic markers (i.e. color of epiderm ) and by analyzing genotypes using microsatellite marker (SSR). Position of different genotypes in cell layers of periclinal chimeras will be determined by adventive roots genotyping. Results of this research, on possibilities of grapevine synthetic chimeras development, will have a significant influence on future development of grapevine chimeral breeding.]]></summary_en></project><project>
<id>2905</id><title_hr><![CDATA[Novootkrivene cirkulirajuće izoforme BMP1  proteina kao biomarkeri i terapijski ciljevi za humane bolesti]]></title_hr><title_en><![CDATA[Newly discovered BMP1 circulating isoforms as biomarkers and therapeutic targets for human diseases]]></title_en><user_id>4108</user_id><user_firstLast_name>Lovorka Grgurević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2014-09</proposal_call><code>UIP-2014-09-3509</code><acronim><![CDATA[BMP1-IsoFor]]></acronim><duration>01.01.2016 - 31.12.2018</duration><status>Završio</status><financ_value>132.590,09 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>13196, 13183, 6237, 13232, 3289, 13334, 1278, 965, </team_members_id><team_members_names><![CDATA[Morana Jankolija, Tatjana Bordukalo Nikšić, Vera Kufner, Ruđer Novak, Ivo  Dumić-Čule, Hermann Oppermann, Mario Matijašić, Hana Čipčić Paljetak, ]]></team_members_names><keywords_hr><![CDATA[metaloproteinaze, kronično bubrežno zatajenje, jetrena fibroza, izoforme, humanizirana protutijela]]></keywords_hr><keywords_en><![CDATA[metalloproteinases, chronic kidney disease, liver fibrosis, isoforms, humanized antibodies]]></keywords_en><summary_hr><![CDATA[Pokušali smo identificirati i karakterizirati strukturu cirkulirajućih koštanih morfogenetskih proteina (BMP) u ljudskoj plazmi i izravno ih povezati uz patološka zbivanja u određenom organu. Umjesto toga, slučajno smo otkrili cirkulirajuće izoforme metaloproteinaza koji su proizvod Bmp1 gena: BMP1-3 (mTld) u zdravih muškaraca i pacijenata s kroničnom bubrežnom bolešću (CKD), BMP1-4 u pacijenata s cirozom jetre (LC), BMP1-5 u pacijenata s akutnim infarktom miokarda (AMI), i BMP1-7 u oboljelih od pankreatitisa. Kasnije smo pokazali da primjena BMP1-3 proteina pogoršavaju, dok BMP1-3 poliklonsko antitijela popravljaja bubrežnu funkciju i povećava preživljenje u štakora s CKD. Dodatno, inhibicija proteina BMP1-3 te kombinacija s neutralizacijom BMP1-4 proteina poboljšava funkciju jetre i srca nakon LC, odnosno AMI. Stoga pretpostavljamo da je molekula BMP1-3 ključna u signalnom putu koji regulira fibrozu te da njegova neutralizacija može ograničiti progresiju stvaranja ožiljka. U skladu s ovim rezultatima predlažemo novi znanstveni koncept u savladavanju fibroze preko glavnog te organ-specifičnih regulatornih puteva kroz sljedeće ciljeve: 1/ proizvesti izoforme BMP1 proteina i odgovarajuća monoklonska antitijela; 2/ odrediti specifične substrate za BMP1 izoforme; 3/ razviti novi osjetljivi biološki test za mjerenje BMP1 izoformi u različitim životinjskim eksperimentalnim modelima;  4/ istražiti ulogu BMP1 izoformi u životinja sa CKD i LC. Varijabilna domena najučinkovitijih monoklonskih antitijela će biti sekvencionirana i humanizirana s ciljem terapijske primjene i potencijalnog razvitka novog dijagnostičkog markera. Ovim novim pristupom pokušava se definirati ključna ciljna molekula za zaustavljanje progresije ili poboljšanje u CKD i LC. Naša hipoteza je da modulacija ili inhibicija BMP1 izoformi predstavlja budućnost terapijskih intervencija u spriječavanju fibroze]]></summary_hr><summary_en><![CDATA[We sought to identify and characterize the structure of circulating bone morphogenetic proteins (BMPs) in the human plasma directly associated with organ specific pathology. Instead, we unexpectedly discovered circulating Bmp1 gene metalloproteinase isoforms: BMP1-3 (mTld) in healthy men and in patients with chronic kidney disease (CKD), BMP1-4 in liver cirrhosis (LC), BMP1-5 in acute myocardial infarction (AMI), and BMP1-7 in pancreatitis. We then showed that injections of BMP1-3 protein deteriorate, while BMP1-3 neutralizing polyclonal antibody improves the kidney function and prevents death in rats with CKD. In addition, inhibition of BMP1-3 alone and in combination with a BMP1-4 antibody improved the organ function in LC and AMI. We assume that BMP1-3 represents a core regulatory pathway molecule essential in fibrosis, and its targeting may be sufficient to limit fibrosis progression. In line with these findings, in this project we propose a new scientific concept in combating fibrosis using core and organ specific regulatory pathways, through pursuing the following objectives: 1/ to produce recombinant BMP1 isoform proteins and related neutralizing isoform-specific monoclonal antibodies; 2/ to determine specific BMP1 isoform substrates; 3/ to develop new sensitive plasma bioassays for measuring BMP1 isoforms in different animal experimental models;  4/ to explore the role of BMP1 isoforms in the pathology and function of animals with CKD and LC. The most efficacious monoclonal antibodies variable domain will be sequenced, and than humanized for potential development of new diagnostic tools and therapeutic application. This novel approach aims to acquire the first candidate specific treatment for halting or reversing the progression of CKD and LC. We hypothesize that modulation and/or inhibition of BMP1 isoforms represents future of diagnostic and therapeutic interventions in the field of molecular and translational medicine of fibrosis.]]></summary_en></project><project>
<id>2915</id><title_hr><![CDATA[Hiperfosforilacija, agregacija i transsinaptički prijenos tau proteina u Alzheimerovoj bolesti: analiza likvora i ispitivanje potencijalnih neuroprotektivnih spojeva]]></title_hr><title_en><![CDATA[Tau protein hyperphosphorylation, aggregation and trans-synaptic transfer in Alzheimer&#39;s disease: cerebrospinal fluid analysis and assessment of potential neuroprotective compounds]]></title_en><user_id>11124</user_id><user_firstLast_name>Goran Šimić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-9730</code><acronim><![CDATA[ALZTAUPROTECT]]></acronim><duration>12.10.2015 - 11.10.2019</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, Clinical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>8532, 5057, 12685, 3314, 2684, 13238, 3319, 6740, 20884, 25387, 26549, </team_members_id><team_members_names><![CDATA[Mirjana Babić, Maja Jazvinšćak Jembrek, Danira Bažadona, Domagoj Đikić, Fran Borovečki, Vesna Benković, Nada Oršolić, Željka Petelin Gadže, Mirta Boban, Klara Zubčić, Ena Španić, ]]></team_members_names><keywords_hr><![CDATA[Alzheimerova bolest, cerebrospinalna tekućina (likvor), ELISA, neurofibrilarna degeneracija, neuroprotektivni spojevi, tau protein, tioflavin S ]]></keywords_hr><keywords_en><![CDATA[Alzheimer&#39;s disease, cerebrospinal fluid, ELISA, neurofibrillary degeneration, neuroprotective compounds, tau protein, thioflavine S]]></keywords_en><summary_hr><![CDATA[Za Alzheimerovu bolest (AB) ne postoji uzročno liječenje jer su brojni dosadašnji pokušaji intervencije temeljeni na amiloidnoj kaskadnoj hipotezi bili neuspješni. Usporedno s napretkom razumijevanja uloge tau proteina u patogenezi AB, metabolizam tau proteina je postao i važan terapijski cilj. Naime, smatra se da je u AB ravnoteža između kinaza i fosfataza tau proteina narušena, što dovodi do njegove hiperfosforilacije. Posljedično se povećava i frakcija tau proteina nevezanih za mikrotubule, pa se hiperfosforilirani tau monomeri vežu jedan za drugoga proizvodeći oligomere. Spajanje tau oligomera dovodi do oblikovanja sparenih uzvojitih filamenata, od kojih se sastoje sve neurofibrilarne promjene za koje je dokumentirano da predstavljaju najraniji neuropatološki događaj (tzv. &#39;&#39;pre-tangle&#39;&#39; stadij) od ključnog značaja za patogenezu AB. Ciljevi našeg projekta su: 1) bolje definirati odnos između bioloških biljega ranih stadija AB: ukupnih i fosforiliranih tau proteina, kao i amiloida ß u cerebrospinalnoj tekućini (likvoru) bolesnika s AD, MCI (blagi spoznajni poremećaj) i kontrolnih ispitanika. Uporabom inovativnog ELISA postupka i modificiranog eseja pomoću tioflavina S, u uzorcima likvora odrediti ćemo omjer između monomera i oligomera (agregata) tau proteina. Ti će novi podatci biti uspoređeni s kliničkim, neuropsihološkim i MRI nalazima; 2) testirati ćemo neke poznate i potencijalno neuroprotektivne spojeve (donepezil, klorgilin, nekoliko različitih flavonoida, te PF9601N i ASS234) na fosforilaciju tau proteina izazvanu okadaičnom kiselinom i nokodazolom u kulturama SH-SY5Y i P19 stanica. Epitope tau proteina fosforilirane na Thr181, Ser199 i Thr231 analizirati ćemo ELISA postupkom, a one na epitopima Thr202, Thr205, Ser396 i Ser404 pomoću westernske razložbe; i 3) istražiti ćemo biokemijski i imunocitokemijski transsinaptičko širenje neurofibrilarne degeneracije i razinu izraženosti tau mRNA nakon injekcije tau oligomera u entorinalnu moždanu koru miša.]]></summary_hr><summary_en><![CDATA[There is no effective treatment for Alzheimer’s disease (AD). As many drugs discovery attempts based on the amyloid cascade hypothesis have not been successful, tau protein has become an increasingly important therapeutic target owing to advances in understanding of its role in AD pathogenesis. In AD, the balance of tau kinase and phosphatase activity is shifted, creating a highly phosphorylated species of tau. This raises the fraction of unbound tau, which is no longer attached to microtubules, allowing for monomeric hyperphosphorylated tau to bind to one another to produce oligomers. Fusion of these oligomeric species leads to the formation of paired helical filaments, the primary constituent of neurofibrillary changes, which have been documented to be an early and pivotal event (so-called „pre-tangle“ stage) in the pathogenesis of AD. Our aims are: 1) to define better the relationship between the early AD biomarkers total and phospho-tau proteins, as well as amyloid ß in cerebrospinal fluid (CSF) of AD, MCI (mild cognitive impairment), and control subjects. By using innovative ELISA and modified thioflavin S binding assay on CSF samples, we will also assess the ratio between monomer and oligomer (aggregated) tau species. These new data will be correlated to clinical, neuropsychological, and MRI findings; 2) to test the effect of several known and potentially neuroprotective compounds (donepezil, clorgyline, several flavonoids, PF9601N and ASS234, among others) on tau phosphorylation induced by okadaic acid and nocodazole in SH-SY5Y and P19 cell cultures. Tau epitopes phosphorylated at Thr181, Ser199 and Thr231 residues will be analyzed by ELISA, while p-tau epitopes at Thr202, Thr205, Ser396 and Ser404 will be analyzed by Western blot; and 3) to investigate biochemically and immunocytochemically the trans-synaptic spreading of neurofibrillary degeneration and tau mRNA expression after the injection of tau oligomers in the mouse entorhinal cortex.]]></summary_en></project><project>
<id>2916</id><title_hr><![CDATA[Satelitska DNA u genskoj regulaciji i ekološkoj adaptaciji]]></title_hr><title_en><![CDATA[Satellite DNA in gene regulation and environmental adaptation ]]></title_en><user_id>183</user_id><user_firstLast_name>Đurđica Ugarković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-3733</code><acronim><![CDATA[SatGenReg]]></acronim><duration>01.09.2015 - 30.11.2019</duration><status>Završio</status><financ_value>123.299,49 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>3003, 559, 1280, 21311, 21338, </team_members_id><team_members_names><![CDATA[Branka Bruvo Mađarić, Isidoro Feliciello, Zeljka Pezer Sakac, Antonio Sermek, JURE SKEJIĆ, ]]></team_members_names><keywords_hr><![CDATA[satelitska DNA, genska ekspresija, epigenetika, genska regulacija, adaptacija, Tribolium]]></keywords_hr><keywords_en><![CDATA[satellite DNA, gene expression, epigenetics, gene regulation, adaptation, Tribolium]]></keywords_en><summary_hr><![CDATA[Ponovljena DNA kao npr. transpozoni, može biti izvor regulatornih sekvenci te doprinijeti raspršenju regulatornih elemenata unutar eukariotskog genoma. Međutim, utjecaj na gensku regulaciju druge skupine vrlo zastupljenih, uzastopno ponovljenih sekvenci DNA kao što je satelitska DNA, nije do sada pokazan. U crvenom brašnaru Tribolium castaneum (Coleoptera) satelitska DNA igra važnu ulogu u regulaciji i remodeliranju heterokromatina tijekom razvoja i odgovora na vanjski stres. Ekspresija glavne satelitske DNA je jako potaknuta termičkim stresom, a povećana razina malih interferirajućih RNA (siRNA) koje potječu od satelitske DNA je praćena povećanjem represivnih epigenetskih modifikacija na histonima u heterokromatinu. Uz prisustvo u heterokromatinu, kratki odsječci satelitske DNA su raspršeni u blizini protein-kodirajućih gena u eukromatinu. Transkripcija glavne satelitske DNA osjetljiva na okolišne uvjete kao i njena raspršenost u susjedstvu gena upućuje na moguću ulogu satelitskih elemenata u regulaciji genske aktivnosti i adaptaciji na uvjete u okolišu.Cilj predloženog projekta je ispitati ulogu satelitske DNA u regulaciji aktivnosti gena u kukcu T. castaneum. Mi pretpostavljamo da siRNA koja potječe od satelitskih DNA utječe na epigenetski status dijelova eukromatina koji sadrže raspršene satelitske elemente na način da specifično navodi kromatinske modifikatore, primarno histonske metiltransferaze, na te regije. To može dovesti do nastanka heterokromatina na raspršenim satelitskim DNA elementima  i njegovog širenja na susjedna područja. Takova „heterokromatizacija“ može utjecati na ekspresiju susjednih gena, vjerojatno smanjujući njihovu aktivnost. Očekujemo da će naši rezultati po prvi put pokazati ulogu satelitskih DNA u podešavanju genske ekspresije i u ekološkoj adaptaciji.]]></summary_hr><summary_en><![CDATA[Repetitive elements such as transposons can be a source of regulatory sequences and could act to distribute regulatory elements throughout the genome. However, for the repetitive elements organized in tandem, known as satellite DNAs, role in gene regulation is not described till now. In the red flour beetle Tribolium castaneum (Coleoptera) satellite DNAs play an important role in heterochromatin regulation and remodelling during development and environmental stress response. Expression of a major satellite DNA is strongly induced by heat shock, and increased level of satellite-derived small interfering RNAs (siRNAs) is accompanied by increase of repressive epigenetic modifications of histones at heterochromatin. In addition to their presence in the heterochromatin, short stretches of satellite DNA have been mapped in the close vicinity of numerous genes within euchromatin. The environmentally susceptible transcription of a major satellite DNA as well as its distribution close to protein-coding genes provides strong support for the role of satellite DNA in gene regulation and adaptation to different environmental conditions.The aim of the proposed project is to investigate the gene-regulatory role of satellite DNAs in insect T. castaneum. We propose that satellite DNA-associated siRNAs could affect epigenetic state of euchromatic regions containing dispersed satellite elements by targeting these elements in a sequence-specific manner and by guiding chromatin modifiers, primarily histone methyltransferase. This could result in heterochromatin assembly at dispersed satellite DNA elements and its spreading to the flanking region. Such “heterochromatization” is expected to influence the expression of nearby genes, most probably by decreasing the level of gene expression. We expect that our results will for the first time demonstrate a role of satellite DNAs in the modulation of protein-gene expression and in environmental adaptation. ]]></summary_en></project><project>
<id>2920</id><title_hr><![CDATA[Model rasta aneurizme temeljen na biokemijskim i mehaničkim podražajima ]]></title_hr><title_en><![CDATA[BioChemoMechanical Modeling of Aneurysmal Growth]]></title_en><user_id>1010</user_id><user_firstLast_name>Igor Karšaj</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-7382</code><acronim><![CDATA[BCMModAneuGr]]></acronim><duration>01.10.2015 - 30.09.2019</duration><status>Završio</status><financ_value>115.747,56 eur</financ_value><scie_area_hr>Tehničke znanosti, Biomedicina i zdravstvo, </scie_area_hr><scie_area_en>Technological sciences, Biomedicine and health sciences, </scie_area_en><scie_field_hr>Strojarstvo, </scie_field_hr><scie_field_en>Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>12954, 12791, 1012, 19003, 25392, </team_members_id><team_members_names><![CDATA[Ivo Lovričević, Vedran  Vindiš , Lana Virag, Nino Horvat, Josip Živić, ]]></team_members_names><keywords_hr><![CDATA[aneurizma, abdominalna aorta, intraluminalni tromb, rast i promjena strukture, hiperelastičnost, naprezanja, prilagodba, razgradnja elastina, kolagen]]></keywords_hr><keywords_en><![CDATA[aneurysm, abdominal aorta, intraluminal thrombus, growth and remodeling, hyperelasticity, stress, adaptation, elastin degradation, collagen turnover]]></keywords_en><summary_hr><![CDATA[Modeliranje biokemijskih kao i mehaničkih promjena tijekom razvoja intraluminalnog tromba (ILT) ima potencijal da pomogne nam odgovoriti na pitanje kako dolazi do rasta aneurizme i što uzrokuje njenu rupturu. Konačni cilj ovog istraživanja je utvrditi promjene koje s javljaju rastom aneurizme. Simulirat ćemo od početnog krvnog ugruška pa kasnog stadija aneurizme promjera većeg od 5 cm. Pretpostavljamo da povećanje AAA je izravna posljedica razvoja ILT.  Predlažemo sljedeće ciljeve za ovaj projekt:Cilj 1: Razviti model rasta i promjene strukture fuziformne aneurizme koji je moguće koristiti u paketu za konačne elemente.Cilj 2: Potrebno je razviti trodimenzijski model rasta i promjene strukture sakularne aneurizme s uključenim intraluminalnim trombom.Cilj 3: Potrebno je ispitati različite hipoteze o tome kako dolazi do rupture ili stabilizacije AAA na realističnoj geometriji.Uspješno ostvarenje navedenih ciljeva bit će veliki napredak u polju biomehanike krvnih žila jer će omogućiti po prvi put praćenje kinetike razvoja intraluminalnog tromba unutar AAA i otkrivanje faktora koji utječu na rast i rupturu aneurizme.]]></summary_hr><summary_en><![CDATA[Proper biochemomechanical modeling of the development of an intraluminal thrombus (ILT) has the potential to help us answer the question about reasons for aneurysmal growth and to define parameters influencing potential for rupture?. The overall goal of this project, therefore, is to quantify the development of ILT from the initial blood clot to a mature formation, with special attention to changes in the clot structure. Our hypothesis is that AAA growth is a direct consequence of ILT development. We propose following aims for this proposal:Aim 1: To develop a finite element growth and remodeling model of thrombus-laden fusiform aneurysm from the moment of initiation.Aim 2: To develop a 3-D finite element growth and remodeling model of thrombus-laden saccular abdominal aortic aneurysm from the healthy aorta.Aim 3: To test different hypothesis on AAA rupture and stabilization on realistic geometry from Aim 2.Successful realization of these aims will advance the field of vascular mechanics by allowing for the first time quantification of kinetics of an intraluminal clot within AAA, and factors that significantly influence aneurysmal growth and risk of the rupture. ]]></summary_en></project><project>
<id>2921</id><title_hr><![CDATA[Raspad Habsburške Monarhije i transfomacije na istočnojadranskom prostoru (1917.-1923.)]]></title_hr><title_en><![CDATA[THE COLLAPSE OF HABSBURG MONARCHY AND TRANFORMATIONS OF EASTERN ADRIATIC REGION (1917-1923)]]></title_en><user_id>1131</user_id><user_firstLast_name>Ante  Bralić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-7822</code><acronim><![CDATA[JADRANTRANSFORMACIJE]]></acronim><duration>15.05.2015 - 14.05.2019</duration><status>Završio</status><financ_value>52.491,21 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Povijest, </scie_field_hr><scie_field_en>History, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zadru]]></institution_hr><institution_en><![CDATA[University of Zadar]]></institution_en><team_members_id>3175, 1375, 2931, 4263, 2796, 2557, 2763, 2746, 22836, 914, </team_members_id><team_members_names><![CDATA[Zlatko Begonja, Zdravka Jelaska Marijan, Andreas Guidi, Branko Kasalo, Sanda Uglešić, Ante Gverić, Marko Trogrlić, Ante Batović, Matic  Batič, BORUT KLABJAN, ]]></team_members_names><keywords_hr><![CDATA[Istočni Jadran, Dalmacija, Habsburška Monarhija, Prvi svjetski rat, Elite]]></keywords_hr><keywords_en><![CDATA[Eastern Adriatic, Dalmatia, Habsburg Monarchy, World War One, Elites]]></keywords_en><summary_hr><![CDATA[Razdoblje između sloma Austro-Ugarske Monarhije i stvaranja novih država bilo je iznimno turbulentno razdoblje u političkom, društvenom i nacionalnom pogledu. Istraživanje bi započelo Svibanjskom deklaracijom 1917. godine koja je potaknula političko gibanje na, do tada “zamrznutoj” političkoj sceni, a završilo bi se završetkom povlačenja talijanskih vojnih snaga 1923. godine iz III. okupacijske zone. Poseban fokus bit će posvećen prilikama u Dalmaciji, a komplementarno će se analizirati prilike u drugim krajevima Istočnog Jadrana.Ciljevi projekta:1.	Objasniti utjecaj složenog sklopa uzroka koji su doveli do sloma Habsburške Monarhije i njihov utjecaj na javno mnijenje na istočnoj obali Jadrana, a posebno u Dalmaciji (1917.-1918.).2.	Istražiti utjecaj vanjskih, međunarodnih čimbenika na političke i društvene procese koji se odvijaju u promatranom razdoblju na istočnoj obali Jadrana u kontekstu nedefiniranih državnih granica i konfliktnih situacija. 3.	Proučiti promjene narativa u završnim procesima nacionalnih integracija (dalmatinskih Hrvata, Srba i Talijana, te tršćanskih Slovenaca) što je povezano s novim političkim i društvenim okruženjem.4.	Istražiti transformaciju i prilagođavanje &#39;starih&#39; elita novom društvenom okruženju.5.	Objasniti nastanak i djelovanje novih političkih organizacija nakon 1918. godine, te njihov utjecaj u dalmatinskom društvu.  Ova problematika je do sada, relativno slabo istražena. Jedan od najvećih problema je istovremeno i paraleno djelovanje više institucija na dalmatinskom i stičnojadranskom području u razdoblju od 1918. do 1923. što je osobito izraženo u prvom razdoblju do Rapallskog ugovora 1920.]]></summary_hr><summary_en><![CDATA[The period between the collapse of the Habsburg Monarchy and creation of new nation states was an exceptionally turbulent period in political, social and national sense. The research would begin with the May Declaration of 1917, which prompted political movement on previously “idle” political scene, and would end with final retreat of Italian military forces from the third occupation zone in 1923 in Dalmatia. Special focus will be devoted to the situation in Dalmatia, and complementary analysis will handle with the situation in other parts of the Eastern Adriatic.Project objectives:1.	Analyze complex set of causes that led to the collapse of the Habsburg Monarchy and their influence on public opinion in Eastern Adriatic region, especially in Dalmatia (1917-1918)2.	Explore the influence of external, international, factors on political and social processes in Dalmatia during the observed period, within the context of unidentified national borders and conflict situations.3.	Study the narrative changes in final processes of national integrations (of Dalmatian Croats, Serbs, and Italians, and Slovenes from Trieste) in connection to new political and social environment.4.	Investigate how the “old” elites transformed and adapted to new social environment.5.	Explain formation and activities of new political organizations after 1918 and their influence on Dalmatian society.This topic has not yet been fully explored. One of the biggest research issues are simultaneous and parallel activities of various different institutions in Dalmatia and other Eastern Adriatic regions between 1918 and 1923, particularly during the first period, prior to the Treaty of Rapallo.]]></summary_en></project><project>
<id>2923</id><title_hr><![CDATA[Mehanokemijska reaktivnost pod kontroliranim uvjetima temperature i atmosfere za čistu sintezu funkcionalnih materijala]]></title_hr><title_en><![CDATA[Mechanochemical reactivity under controlled temperature and atmosphere for clean synthesis of functional materials]]></title_en><user_id>280</user_id><user_firstLast_name>Krunoslav Užarević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2014-09</proposal_call><code>UIP-2014-09-4744</code><acronim><![CDATA[MECHANOCONTROL]]></acronim><duration>01.04.2016 - 31.03.2019</duration><status>Završio</status><financ_value>130.201,08 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>196, 13070, 3012, 1007, 112, 625, 13224, 21253, 23293, 24360, </team_members_id><team_members_names><![CDATA[Martina Tireli, Emmerling Franziska, Davor Gracin, Marina Juribašić Kulcsar, Manda Ćurić, Ivan Halasz, Tomislav Friscic, Stipe Lukin, Bahar Karadeniz, Tomislav Stolar, ]]></team_members_names><keywords_hr><![CDATA[mehanokemijska sinteza, reaktivnost u čvrstom stanju, in situ monitoring, templatiranje i adsorpcija plinova, funkcionalizacija metal-ugljik veze]]></keywords_hr><keywords_en><![CDATA[mechanochemical synthesis, solid-state reactivity , in situ monitoring, gas-templation and adsorption, functionalization of metal-carbon bond]]></keywords_en><summary_hr><![CDATA[Mehanokemijske reakcije su se nametnule u posljednje vrijeme kao brza i ekološki prihvatljiva alternativa konvencionalnoj kemijskoj sintezi u velikom broju područja, od sinteze nanomaterijala i slitina do supramolekulskih organskih materijala i koordinacijskih mreža. Područje se posebno razvilo uvođenjem novih tehnika, tekućinom potpomognutog mljevenja ili ionima- i tekućinom potpomognutog mljevenja, koji uključuju dodatak aditiva u reakcijske smjese. Unatoč velikom broju objavljenih radova, načini kontrole osnovnih reakcijskih uvjeta, poput temperature i tlaka unutar mehanokemijskog reaktora, još uvijek nisu uvedeni u standardne mehanokemijske postupke. Štoviše, znanja o utjecaju reakcijskih uvjeta i aditiva na mehanizme reakcija mljevenja su još na spekulativnom nivou.Glavni cilj predloženog projekta je istraživanje fundamentalnih aspekata mehanokemijskih reakcija pod kontroliranom tlakom i u određenom rasponu temperatura. Okolišno relevantni plinovi (poput ugljikova(IV) oksida, metana, sumporovih i dušikovih oksida) će se koristiti kao templati ili reaktanti za sintezu poroznih koordinacijskih spojeva ili organskih spojeva. Također, ispitati će se vezanje plinova na neporozne koordinacijske spojeve, te funkcionalizacija ugljikovih atoma iz organometalnih spojeva.Da bismo uspješno ostvarili ciljeve projekta, razviti ćemo mehanokemijske reaktore u kojima će biti moguće kontrolirati temperaturu i tlak. Mehanistički aspekti mehanokemijskih reakcija između plinova i krutina biti će određeni in situ tehnikama praćenja nedavno razvijenih unutar naše grupe.Iskustvo i saznanja prikupljeni implementacijom ovoga projekta će se iskoristiti za istraživanja mehanokemijske sinteze ciljanih materijala, a s krajnjim ciljem stjecanja dubljeg uvida u mehanokemijske reakcije i proširenja  potencijala za njihovu primjenu. Očekujemo da će rezultati projekta imati snažan utjecaj na korištenje reakcija u čvrstom stanju, kako u istraživačkim laboratorijima, tako i u kemijskoj industriji.]]></summary_hr><summary_en><![CDATA[Mechanochemical reactions by milling have recently emerged as excellent, rapid and cleaner alternative to conventional solution synthesis in a number of areas, from nanomaterials and alloys to supramolecular, organic materials and metal-organic frameworks. The area flourished after the introduction of new techniques, liquid-assisted grinding and ion- and liquid assisted grinding, involving additives in the reaction mixtures. Despite a growing rate of published articles, the means of controlling the basic milling reaction conditions, such as temperature and pressure in the vessel, is still not a part of standard milling procedures. Moreover, understanding of the effect of reaction conditions and additives on milling-reaction mechanisms is currently on speculative level.The main objective of this project proposal is to explore fundamental aspects of mechanochemical solid-state reactions under controlled pressure and in a range of temperatures. We will employ different gases (with special focus on environmentally relevant gases such as carbon dioxide, methane and sulfur- or nitric oxides) as reacting agents and templates for the synthesis of porous metal-organic and covalent organic frameworks, to selectively bind pollutant gases to nonporous coordination compounds or to functionalize carbon atoms in organometallic compounds. To successfully implement the objectives of this project proposal, we will develop milling vessels where the described reaction conditions can be achieved. Mechanistic aspects of gas-solid milling reactions will be studied by our novel in situ and real-time monitoring techniques.The experience and knowledge acquired by the project implementation will be applied to mechanochemical formation of target materials in order to broaden understanding and application scope of mechanochemical reactivity. The project results are expected to have a strong transformative effect on solid-state reactivity in a research laboratory as well as in chemical industry.]]></summary_en></project><project>
<id>2933</id><title_hr><![CDATA[Modulacija metaboličkog, endokrinog i antioksidacijskog statusa u mliječnih krava dodavanjem zeolita u hranu]]></title_hr><title_en><![CDATA[Modulation of metabolic, endocrine and antioxidative status in dairy cows by dietary zeolite supplementation]]></title_en><user_id>11178</user_id><user_firstLast_name>Marko Samardžija</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-6601</code><acronim><![CDATA[ModZeCow]]></acronim><duration>15.09.2015 - 14.09.2019</duration><status>Prekinut</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Veterinarska medicina, </scie_field_hr><scie_field_en>Veterinary medicine, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Veterinarski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Veterinary Medicine]]></institution_en><team_members_id>2794, 11250, 11252, 11248, 12376, 11275, 11271, 11273, 11257, 5216, 11266, 12374, 11247, 11245, 3086, 11258, </team_members_id><team_members_names><![CDATA[Miroslav Benić, Tomislav Dobranić, Vesna Dobranić, Dražen Đuričić, Zlata Flegar-Meštrić, Ivan Folnožić, Iva Getz, Damjan Gračner, Juraj Grizelj, Martina Lojkić, Nino Maćešić, Sonja Perkov, Paola Roncada, Romana Turk, Hrvoje Valpotić, Silvijo Vince, ]]></team_members_names><keywords_hr><![CDATA[NEB, zeolit u hrani, plodnost, mastitis, mliječne krave]]></keywords_hr><keywords_en><![CDATA[NEB, dietary zeolite, fertility, mastitis, dairy cows]]></keywords_en><summary_hr><![CDATA[Nakon porođaja, naglo se povećaju hranidbene potrebe organizma zbog proizvodnje mlijeka i krave ulaze u razdoblje negativnog energetskog statusa (NEB) koji neposredno utječe na funkciju jajnika prouzrokujući izostanak pravilne ciklične aktivnosti jajnika tijekom puerperija i smanjenje plodnosti. NEB nije moguće izbjeći, ali je zato moguće umanjiti njegovo trajanje i jačinu. Reproduktivni poremećaji u krava mogu se pripisati značajnom smanjenju tjelesne kondicije tijekom puerperija kao i sistemskim promjenama metaboličkih, endokrinih i oksidacijskih pokazatelja zbog nedostatnog unosa hrane. Posljedično, energetska neravnoteža zbiva se zbog povećane mliječnosti nakon porođaja, periporođajnog stresa i/ili bolesti koje se javljaju tijekom puerperija. Te bolesti imaju značajan negativni ekonomski utjecaj tijekom puerperija i u razdoblju nakon njega zbog pojave trajne jalovosti. Jedna od najznačajnijih bolesti krava tijekom puerperija je mastitis koji prouzrokuje znatne ekonomske gubitke, zbog otežane dijagnostike subkliničkog oblika. Smatra se da zeolit klinoptilolit (KPL) može modulirati metabolički, endokrini i antioksidacijski status u mliječnih krava i stoga unaprijediti njihovo zdravlje, plodnost i mliječnost. Ciljevi projekta su vrednovati učinke nutritivne modulacije KPL u hrani na NEB, plodnost i produktivnost te pojavnost subkliničkog mastitisa radi rane dijagnostike oksidacijskog stresa i sistemskog/lokalnog upalnog odgovora povezanog s reproduktivnim i produktivnim poremećajima u mliječnih krava. Očekivani rezultati istraživanja na projektu uključit će dobro definirane pozitivne učinke nutritivne modulacije dodatkom KPL u hranu na: (1) NEB, plodnost i produktivnost s obzirom na tjelesnu kondiciju i paritet tijekom prijelaznog razdoblja i kasnog puerperija; (2) pojavnost/jačinu subkliničkog mastitisa u mliječnih krava. Sveukupno, ti će učinci u praksi doprinijeti unaprjeđenju zdravlja i ekonomskih pokazatelja u govedarskoj proizvodnji u Hrvatskoj i inozemstvu. ]]></summary_hr><summary_en><![CDATA[Nutritional requirements of dairy cows are rapidly increasing following parturition due to milk production and thus animals inevitably enter into negative energy balance (NEB) which indirectly affecting ovaries function causing failure of regular ovarian activity during puerperium and consequently decreased fertility. The NEB could not be avoided by any known treatments but it is possible to decrease its duration and severity. Reproductive disorders in cows could be ascribed to significant decrease of body condition during puerperium and to systemic changes of metabolic, endocrine and oxidative parameters due to insufficient feed intake. Consequently, energy imbalance occurs due to increased milk production following parturition, peripartal stress and/or puerperal diseases. Such diseases have significant negative economic impact, during puerperium and afterwards by appearance of sterility. One of the most important puerperal diseases is mastitis which causes large economic losses particularly due to difficulties in diagnosis of its subclinical form. It is assumed that zeolite clinoptilolite (CPL) might modulate metabolic, endocrine and antioxidative status in dairy cows and thus improve their health, fertility and milk production. The objectives of the project are to evaluate effects of nutritive modulation by dietary CPL on: NEB, fertility, productivity and incidence of subclinical mastitis for early recognition of oxidative stress and systemic/local inflammatory responses involved in reproductive and productive disorders in dairy cows. The expected outcomes of the project will include well defined positive effects of nutritive modulation by dietary CPL on: (1) NEB, fertility and productivity regarding body condition and parity during transition period and late puerperium; (2) incidence/severity of subclinical mastitis in dairy cows. Altogether, these will contribute in practice to improve health and economical parameters in cattle production in Croatia and abroad.]]></summary_en></project><project>
<id>2934</id><title_hr><![CDATA[JADRANSKA PRIČA - INTERDISCIPLINARNO ISTRAŽIVANJE JADRANSKIH NARATIVA]]></title_hr><title_en><![CDATA[ADRIATIC TALE - INTERDISCIPLINARY RESEARCH OF ADRIATIC NARRATIVES]]></title_en><user_id>8327</user_id><user_firstLast_name>Joško Božanić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-9300</code><acronim><![CDATA[ADRIANA]]></acronim><duration>01.10.2015 - 30.09.2019</duration><status>Završio</status><financ_value>76.293,05 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filologija, Etnologija i antropologija, </scie_field_hr><scie_field_en>Philology, Ethnology and anthropology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>12702, 12699, 11114, 12688, 12608, 13033, 13303, 13535, 13610, 12992, 7827, 13358, 24402, </team_members_id><team_members_names><![CDATA[Anita Runjić-Stoilova, Inoslav Bešker, Eni Buljubašić, Marijana Tomelić Ćurlin, Marina Blagaić Bergman, Antonela Pivac, Filip Galović, Natalie Dupré, Elis Deghenghi Olujic, Ines Grgurinović, Danica Škara, Srecko Jurisic, Paula Jurišić, ]]></team_members_names><keywords_hr><![CDATA[humorizam, književnost, usmenost, stilistika, Jadran, dijalekt, narativ, semiotika]]></keywords_hr><keywords_en><![CDATA[humorism, literature, orality, stylistics, Adriatic, dialect, narrative, semiotics]]></keywords_en><summary_hr><![CDATA[ Atribut „jadranski“ ne pojavljuje se u hrvatskoj književnoj historiografiji ni znanosti o književnosti kao kvalifikativ koji bi definirao literarnu posebnost ni kao stilska, ni kao tematska, niti kao kulturološka odrednica. Zanemarivanje maritimnosti rezultira redukcijom kulturološkog diverziteta u recepciji nacionalne književnosti, umjetničke i usmene. Polazeći od teze da je kvalifikativ „jadranski“ bitna odrednica jednog od hrvatskih kulturnih identiteta, ovaj projekt želi doprinijeti istraživanju fenomena maritimnosti hrvatske kulture na području narativa oralne pripovjedne  književnosti, kako fikcionalne tako i nefikcionalne, i njena refleksa u narativima umjetničke književnosti u sinkronijskoj i dijakronijskoj perspektivi. U tome je i specifičan doprinos ovoga  projekta budući da on pokriva veliko neistraženo područje usmene književnosti i njena utjecaja na umjetničku književnost. Projekt se temelji na ideji sustavnog istraživanja usmene i zapisane građe oralne nefikcionalne i fikcionalne književnosti, izvan klasičnog folklorističkog okvira percepcije fenomena literarature kao žanrovski i poetološki definiranog diskursa. Ovo istraživanje nije strogo omeđeno granicama jezika jednog etnosa (hrvatskog), već uključuje i transetničke utjecaje i prožimanja zadana istom kulturalnom matricom adrianstva. To je dijaloška kultura čiji je temeljni princip humorizam. Zapisat će se i sistematizirati prikupljena građa te provesti sustavna analiza, valorizacija i interpretacija tekstova s različitih aspekata: literarnog, lingvističkog, etnološkog i kulturnoantropološkog, komparativnog i rodnog, a istraživanje će uključiti različite tipove interpretacije na područjima: stilistike, naratologije, književne teorije, dijalektologije, leksikologije / leksikografije, semiotike, retorike, etnografije i kulturne antropologije. Pragmatični dio istraživačkog programa realizirat će se dizajniranjem atraktivnih ambijentalnih narativa za potrebe jadranskih kulturnih itinerara.]]></summary_hr><summary_en><![CDATA[Within Croatian literary theory and historiography, the attribute ‘Adriatic’ does not signify any (relevant) determinant of literary quality, whether stylistic, thematic or cultural. The disregard of the maritime cultural aspects reduces the cultural diversity in the reception of national literature, both authored/written and oral. With the premise that the attribute &#39;Adriatic&#39; is a significant determinant of one of Croatia&#39;s cultural identities, this project aims to contribute to the research of the phenomenon of Croatian culture&#39;s maritimity in the area of oral literature narratives,  both fictional and non-fictional, as well as narratives of national written literature in its synchronic and diachronic perspective. The outstanding value and specific contribution of this project is in covering a field that has not yet been researched in Croatian literary studies. The project is based on the idea of definition, interpretation and valorisation of the Adriatic component of Croatian literature and the systematic research of oral and recorded stories of various narrative and protonarrative types related to specific areas of the Adriatic space. The collected data will be systematized and subjected to a detailed analysis and textual interpretation from various perspectives: literary, linguistic, ethnological, cultural, antropological, comparative and the perspective of gender. The research will include various types of interpretation in the areas of stylistics, narratology, literary theory, dialectology, lexicology / lexicography, semiotics, rhetoric, ethnography and cultural anthropology. Results will be dissaminated through the publication of books and research papers in internationally cited journals and proceedings of the international conference on the subject of this project. The practical side of this research project will be implemented through the creation of attractive ambient narratives as the basis of Adriatic cultural itineraries. ]]></summary_en></project><project>
<id>2936</id><title_hr><![CDATA[RIMSKI GROBNI SPOMENICI JUGOZAPADNE PANONIJE U SVOME MATERIJALNOM, DRUŠTVENOM I RELIGIJSKOM KONTEKSTU]]></title_hr><title_en><![CDATA[ROMAN FUNERARY MONUMENTS OF SOUTH-WESTERN PANNONIA IN THEIR MATERIAL, SOCIAL, AND RELIGIOUS CONTEXT]]></title_en><user_id>7449</user_id><user_firstLast_name>branka migotti</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-4632</code><acronim><![CDATA[RGSP/RFMP]]></acronim><duration>04.05.2015 - 03.05.2018</duration><status>Završio</status><financ_value>45.924,35 eur</financ_value><scie_area_hr>Humanističke znanosti, Prirodne znanosti, </scie_area_hr><scie_area_en>Humanities, Natural sciences, </scie_area_en><scie_field_hr>Arheologija, Geologija, </scie_field_hr><scie_field_en>Archeology, Geology, </scie_field_en><institution_hr><![CDATA[Hrvatska akademija znanosti i umjetnosti]]></institution_hr><institution_en><![CDATA[Croatian Academy of Sciences and Arts]]></institution_en><team_members_id>3706, 4660, 3255, 4105, 6682, </team_members_id><team_members_names><![CDATA[Marjeta Šašel Kos, Ivan Radman-Livaja, Ljubica Perinić, Mirko Belak, Hana Ivezić, ]]></team_members_names><keywords_hr><![CDATA[interdisciplinarno istraživanje, jugozapadna Panonija, sjeverna Hrvatska, grobni spomenici, provincijalno-rimsko društvo]]></keywords_hr><keywords_en><![CDATA[interdisciplinary research, south-western Pannonia, northern Croatia, funerary monuments, Romano-provincial society]]></keywords_en><summary_hr><![CDATA[Interdisciplinarno (arheologija, epigrafija, geologija) i cjelovito evidentiraju se, proučavaju i sistematiziraju kameni grobni spomenici triju jugozapadno-panonskih rimskih gradova na prostoru sjeverne Hrvatske: Andautonije  (Ščitarjevo), Siscije (Sisak) i Akva Balisa (Daruvar). Aspekti proučavanja su povijesni, umjetnički i materijalni, a uključuju uvid u odabir vrste spomenika (tituli, stele, sarkofazi, urne, oltari i portretne niše) i odgovarajućeg grobnog rituala (spaljivanje ili tjelesno pokapanje), analize oblika i struktura spomenika, ikonografije i natpisa, te određivanju vrste kamena i kamenolomskog podrijetla. Sistematizacija navedenih podataka omogućit će bolji uvid u društveni i kulturni profil južno-panonskog provincijalnog društva: socijalnu stratifikaciju (statusnu i položajnu, te civilnu i vojničku),  etničke identitete, religijsku pripadnost, te umjetničke trendove i gospodarske aspekte (nastanak domaćih radionica i trgovina mramornim i kamenim izrađevinama na prostoru Norika i Panonije). Prikupljanjem, sistematizacijom i analizom građe koja nikad prije nije bila razmatrana na taj način, osmislit će se svojevrstan pilot projekt, primjenjiv na druge gradove i regije  Rimskog carstva.]]></summary_hr><summary_en><![CDATA[Funerary monuments of  three south-western Pannonian Roman cities in the territory of northern Croatia (Andautonia, Siscia, and Aquae Balissae) are evidenced, compiled, studied, and systematised through an interdisciplinary (archaeological, epigraphic, and geological) and holistic approach. Aspects of the research are historical, artistic, and material, comprising the choice of the monument type (tituli, stelae, sarcophagi, ash-chests, altars, and portrait niches) and corresponding funerary rite (incineration or inhumation), analyses of the monument forms and structures, iconographies, epigraphy, and stone characterisation, that is, establishing the stone used and its quarry source. A systemisation of the acquired data will enable a better insight into the social and cultural profile of the south-Pannonian provincial society, concerning its social stratification (military and civil ranks and statuses), ethnic identities, religious affiliations, artistic trends, as well as economic and trade aspects (the establishment of local stonemasonry workshops and trade in marble and other stone funerary monuments in the Norico-Pannonian region). Through compiling, systematising and analysing of the evidence that had so far never been studied in this way, a kind of a pilot project will be produced, applicable to other towns or regions of the Roman Empire. ]]></summary_en></project><project>
<id>2949</id><title_hr><![CDATA[Novi metodološki pristup biogeokemijskim istraživanjima specijacije metala u tragovima u obalnim vodenim ekosustavima]]></title_hr><title_en><![CDATA[New methodological approach to biogeochemical studies of trace metal speciation in coastal aquatic ecosystems]]></title_en><user_id>12557</user_id><user_firstLast_name>Dario Omanović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-7530</code><acronim><![CDATA[MEBTRACE]]></acronim><duration>01.09.2015 - 31.12.2019</duration><status>Završio</status><financ_value>124.759,44 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, Geologija, </scie_field_hr><scie_field_en>Chemistry, Geology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>827, 101, 4198, 120, 75, 80, 691, 1423, 106, 12837, 5519, 5147, 13204, 13205, 20234, 19764, 23224, 20391, </team_members_id><team_members_names><![CDATA[Ivanka Pižeta, Marina  Mlakar, Neven Cukrov, Vlado Cuculić, Marta Plavšić, Stanislav Frančišković-Bilinski, Petra Vukosav, Vesna Žic, Slađana Strmečki Kos, Ana-Marija Cindrić, Sunčana Geček, Niko Bačić, Garnier Cédric, Lenoble Veronique, Jasmin Pađan, Nuša Cukrov, Saša Marcinek, Filip Pošćić, ]]></team_members_names><keywords_hr><![CDATA[metali u tragovima, specijacija, obalni vodeni ekosustavi, modeliranje,  sedimenti, zagađivala]]></keywords_hr><keywords_en><![CDATA[trace metals, speciation, coastal aquatic ecosystems, modeling, sediments, contaminants]]></keywords_en><summary_hr><![CDATA[Predloženo istraživanje ima za cilj razjasniti nekoliko pitanja vezanih za fizičko-kemijske procese koji reguliraju ponašanje tragova metala (TM) u čistim, ali i u potencijalno zagađenim prijelaznim i priobalnim vodenim ekosustavima. Pokretljivost, reaktivnost kao i bioraspoloživost MT-ova jako ovise o njihovoj kemijskoj specijaciji, bez obzira imaju li ulogu mikronutrijenata ili  su izrazito toksični za organizme.Naša istraživanja usmjerena prema karakterizaciji međusobnog odnosa TM-ova s ostalim makro i mikro konstituentima prirodnih voda, posebno s prirodnom organskom tvari, bit će temeljena na korištenju najnovijih elektrokemijskih i složenih spektrometrijskih tehnika za specijaciju metala. Orijentirat ćemo se naročito na razvoj i usavršavanje metoda za specijaciju, mjernih protokola i mjernih senzora. Modele raspodjele metala razvijene u laboratorijskim uvjetima ispitat ćemo na uzorcima prirodne vode, a primijenit ćemo ih i kod on-site i in-situ mjerenja. Istraživanja će voditi do uspostavljanja niza specifičnih fizičko-kemijskih parametara, procedura i kriterija koja će omogućiti pouzdanu procjenu aktualnog stanja ali i predviđanje budućeg ponašanja TM-ova (specijaciju, mobilnost, biodostupnost/toksičnost) u slučaju lokalnih okolišnih nezgoda (npr. zagađenja) ili globalnih prijetnji (npr. “ocean acidification”).Istraživanja će se provoditi u vodnim područjima raznolikog kemijskog sastava gdje se očekuju promjene fizičko-kemijskih oblika TM-ova (As, Cd, Co, Cr, Cu, Fe, Hg, Ni, Pb, Zn), a uključivat će estuarijska, oksično/anoksična, eutrofička, te čista i zagađena područja, u kojima će se istraživati procesi koji se odvijaju kako na granicama faza, tako i u vodenom i sedimentnom stupcu.Teme istraživanja odabrane su tako da rezultati projekta budu od koristi ne samo široj znanstvenoj zajednici koja radi na problemima specijacije TM-ova nego i institucijama ovlaštenim za upravljanje priobalnim područjima.]]></summary_hr><summary_en><![CDATA[The proposed research aims at elucidating several issues related to the physico-chemical processes governing trace metals (TM) behaviour in pristine, but also in potentially contaminated transitional and coastal aquatic ecosystems. Whether the TMs behave as micronutrients or are highly toxic to organisms, their mobility, reactivity as well as bioavailability, strongly depends on chemical speciation.Our focus will be directed towards characterisation of interactions of TM with other macro and micro constituents of natural waters, particularly with natural organic matter, by employing the most recent approaches utilizing electrochemical and hyphenated spectrometric techniques. Particular effort will be invested in the development and improvement of speciation methods, measurement protocols and sensing electrodes. Methodologies developed under controlled laboratory conditions will be verified using natural water samples and applied in on-site and in-situ field-studies. The research will lead to the establishment of sets of specific measures and criteria which will allow reliable estimation of the actual state, but also the prediction of future behaviour of TMs (speciation, mobility, bioavailability/toxicity) in case of local environmental accidents (e.g. contamination) or global threats (e.g. ”ocean acidification”).Aquatic environments characterized by a variety of chemical compositions will be studied. In such conditions, variations in physical-chemical forms of the studied TMs (As, Cd, Co, Cr, Cu, Fe, Hg, Ni, Pb, Zn) are expected to occur. Study sites will be estuarine, oxic/anoxic, eutrophic and clean/contaminated areas, in which processes occurring at the phase boundaries, as well as in the sediment and water column will be explored.The specific subjects of the research are selected in a way to enable the outcome of the project be valuable not only to the broad scientific community working on TM speciation, but also to the authorities managing coastal zones.]]></summary_en></project><project>
<id>2952</id><title_hr><![CDATA[Menadžment sportskih doživljaja u funkciji oblikovanja učinkovitih poslovnih modela u slabije razvijenim turističkim destinacijama]]></title_hr><title_en><![CDATA[Management of sports experiences in the function of designing effective business models in less developed tourist destinations]]></title_en><user_id>2667</user_id><user_firstLast_name>Marko Perić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2014-09</proposal_call><code>UIP-2014-09-1214</code><acronim><![CDATA[SPORTBIZMODEL]]></acronim><duration>01.06.2015 - 31.05.2018</duration><status>Završio</status><financ_value>38.307,25 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, </scie_field_hr><scie_field_en>Economy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Fakultet za menadžment u turizmu i ugostiteljstvu]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Tourism and Hospitality Managment]]></institution_en><team_members_id>4489, 3013, 2701, 3425, 2894, 6818, </team_members_id><team_members_names><![CDATA[Nicholas  Wise, Sanela Škorić, Daniel  Dragičević, Nataša Kovačić, Jelena Đurkin, Vanja Vitezić, ]]></team_members_names><keywords_hr><![CDATA[Poslovni model, menadžment, sportski doživljaji, sportski turizam, turistička destinacija]]></keywords_hr><keywords_en><![CDATA[Business model, management, sports experiences, sports tourism, tourist destination]]></keywords_en><summary_hr><![CDATA[Opći cilj ovog istraživanja je predložiti učinkovite poslovne modele koji će omogućiti pružateljima usluga sportskog turizma u manje razvijenim turističkim destinacijama da se prilagode tržišnim izazovima te, usredotočujući se na pružanje sportskih doživljaja, održe i povećaju svoje tržišne udjele i pozitivne ekonomske učinke. Formulirano je nekoliko hipoteza: (1) sportski doživljaji koje turisti traže značajno se razlikuju jedni od drugih i mogu biti razvrstani u nekoliko karakterističnih skupina, (2) glavni elementi postojećih poslovnih modela u sportskom turizmu u slabije razvijenim destinacijama identični su glavnim elementima postojećih poslovnih modela najbolje prakse, ali se njihova primjena u praksi razlikuje; (3) analizom prikupljenih primarnih kvalitativnih podataka o karakteristikama postojećih poslovnih modela u sportskom turizmu, moguće je doći do spoznaja relevantnih za oblikovanje učinkovitih poslovnih modela sposobnih pružiti različite vrste sportskih doživljaja. Gorski kotar, kao jedna on slabije razvijenih destinacija u Hrvatskoj, prikladna je lokacija za istraživanje ovih teza. Identificirat ćemo i procijeniti ponudu sportskih sadržaja te provesti anketiranje sportskih turista u Gorskom kotaru kako bi generirali nekoliko vrsta sportskih doživljaja i utvrdili potencijalni odnos između vrsta sportskih doživljaja i izdataka turista. Radi usporedbe identična procedura će se primijeniti i na nekoliko odabranih primjera sportskih događaja i aktivnosti (najbolje prakse) izvan područja Gorskog kotara. Konačno, provest ćemo i interakcijsko istraživanje postojećih poslovnih modela u Gorskom kotaru i najboljih praksi izvan njega. Na taj način dobit ćemo bolji uvid u poslovne modele koji pružaju pojedine doživljaje i moći ćemo predložiti novu verziju konceptualnih poslovnih modela za sve vrste sportskih doživljaja. Spoznaje do kojih ćemo doći mogu biti od velike koristi pružateljima usluga sportskog turizma u Gorskom kotaru i drugim sličnim destinacijama. ]]></summary_hr><summary_en><![CDATA[The overall objective of this research is to propose efficient business models which will allow sports tourism providers in less developed tourist destinations to adapt to the current market challenges and, being focused on providing sports experiences, to maintain and increase their market shares and positive economic impacts. Few hypotheses are formulated: (1) sports experiences that tourists seek differ significantly from one another and can be sorted in several characteristic groups; (2) the main elements of the existing business models of sports tourism in less developed tourist destinations are identical to the main elements of the existing business models of best practice, but their application in practice differ; (3) by analysing the collected primary qualitative data on the characteristics of the existing business models of sports tourism, it is possible to reach knowledge relevant to the design of effective business models capable to provide different types of sports experiences. Gorski kotar (GK) as one of the least developed tourist destinations in Croatia may be appropriate location to explore these issues. We will identify and assess the supply-side (sports events and activities) and conduct a survey on sports tourists in GK in order to generate several types of sports experiences and to determine potential relationship between the types of sports experiences and expenditure of tourists. For benchmarking purposes the same procedure will be applied on selected best practices outside the area of GK. Finally, we will conduct interaction research on existing business models in GK and external best practices. In this way we will get better insight into the business models that deliver different experiences and we will be able to propose the conceptual business models for all types of sports experience. New findings on business models could be of significant benefit for sports tourism providers in GK and other similar destinations.]]></summary_en></project><project>
<id>2953</id><title_hr><![CDATA[Akumulacija, unutarstanično mapiranje i učinci metala u tragovima u akvatičkih organizama]]></title_hr><title_en><![CDATA[Accumulation, Subcellular Mapping and Effects of Trace Metals in Aquatic Organisms]]></title_en><user_id>724</user_id><user_firstLast_name>Marijana Erk</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-4255</code><acronim><![CDATA[AQUAMAPMET]]></acronim><duration>01.09.2015 - 31.12.2019</duration><status>Završio</status><financ_value>127.739,07 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, Kemija, </scie_field_hr><scie_field_en>Biology, Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>11261, 12330, 11251, 11253, 12349, 12871, 12351, 169, 12386, 12339, 12553, 21287, 24444, 25177, </team_members_id><team_members_names><![CDATA[Zrinka Dragun, Vlatka Filipović Marijić, Dušica Ivanković, NESRETE  KRASNIĆI, Renata Matoničkin Kepčija, Sanja Gottstein, Mirela Sertić Perić, Marko  Miliša, Jasna Lajtner, Dirk Schaumlöffel, Etienne GONTIER, Tatjana Mijošek, Zuzana Redžović, Maria de los Angeles Subirana Manzanares, ]]></team_members_names><keywords_hr><![CDATA[metali u tragovima, oslikavanje metala u stanici, unutarstanična raspodjela metala, biomarkeri, toksikologija okoliša, procjena utjecaja na okoliš]]></keywords_hr><keywords_en><![CDATA[trace metals, cellular metal imaging, subcellular metal distribution, biomarkers, environmental toxicology, environmental impact assessment]]></keywords_en><summary_hr><![CDATA[Cilj predloženog projekta je unaprjeđenje dosadašnjih i stjecanje novih spoznaja o tome kako se ribe, rakušci, školjkaši i nametnici riba (kukaši) nose s povišenim koncentracijama metala u slatkovodnim ekosustavima, što će se postići povezivanjem podataka o koncentracijama metala u vodi, akumuliranim metalima te o biomarkerima u bioti s podacima o unutarstaničnom mapiranju metala. Ovo pitanje će se istraživati na različitim biološkim razinama, od unutarstanične do razine organizma, što će omogućiti utvrđivanje načina suočavanja s metalima na različitim razinama biološke organizacije. Multielementna analitička tehnika primijenit će se za analizu metala/metaloida u vodi i u uzorcima biote. U odabranim akvatičkim organizmima istražiti će se i skup biomarkera, uključujući biomarkere općeg stresa te izloženosti i učinaka metala. Oslikavanje metala u stanici provest će se masenom spektrometrijom sekundarnih iona (NanoSIMS), koja trenutno predstavlja najnovije dostignuće tehnike, a omogućava određivanje, vizualiziranje i kvantificiranje raspodjele metala na unutarstaničnoj razini u biološkim materijalima. Primjena NanoSIMS-a u predloženom projektu omogućit će po prvi puta uvid u kretanje i raspodjelu metala u tkivima i stanicama akvatičkih organizama, koji žive u uvjetima povećane izloženosti metalima. Spoznaje, koje će biti rezultat projekta, omogućit će bolje razumijevanje procesa u stanicama i tkivima u kojima sudjeluju metali, kao i posljedica izloženosti akvatičkih organizama metalima. Dodatni cilj je procjena antropogenog utjecaja s obzirom na zagađenje metalima/metaloidima na odabrane slatkovodne ekosustave (rijeke Krka, Ilova), objedinjavanjem kemijskog, biokemijskog i biološkog pristupa, kao i procjena rizika po zdravlje ljudi. Nadalje, rezultati će doprinijeti razvoju planova upravljanja vodama te je stoga ovo istraživanje od strateškog značaja za Republiku Hrvatsku. Predloženi projekt će također omogućiti obrazovanje i usavršavanje nove generacije znanstvenika.]]></summary_hr><summary_en><![CDATA[The aim of the proposed project is to increase our understanding and gain new knowledge on how fish, crustaceans, bivalves and fish parasites (acantocephalans) cope with elevated metal concentrations in freshwater ecosystems by relating data on metal concentrations in water, accumulated metals and biomarker responses in biota to data on intracellular metal mapping. This issue will be tackled at different biological levels, from subcellular to organism, thus establishing how different levels of biological organisation cope with metal exposure. Multielemental analytical technique will be applied to analyse metals/metalloids in water and biota samples and the suit of biomarkers will be studied on selected aquatic organisms encompassing biomarkers of general stress and biomarkers of metal exposure and effect. Secondary ion mass spectrometry (NanoSIMS), as a new, state-of-the-art technique, will be applied for cellular metal imaging in order to measure, visualize and quantify the distribution of specific metals at the sub-cellular level in biological materials. The application of NanoSIMS in the proposed project will for the first time enable the insight into the circulation of metals within tissues and cells of aquatic organisms living under increased metal exposure. The resulting information of the proposed project will generally contribute to better understanding of metal processes in cells and tissues and consequences of metal exposure in aquatic organisms. Additional aim of the project is to evaluate anthropogenic impact on selected freshwater ecosystems (rivers Krka, Ilova) referring to metal/metalloid pollution and using integrated chemical, biochemical and biological approach, as well as to evaluate the risk for human health. In addition, it will contribute to development of water management plans and is therefore, of strategic importance for the Republic of Croatia. The proposed project will also provide capacity building of the next generation of scientists.]]></summary_en></project><project>
<id>2959</id><title_hr><![CDATA[ HIBRIBRIDNE SILICIJSKE NANOSTRUKTURE ZA SENZORIKU]]></title_hr><title_en><![CDATA[ HYBRID SILICON NANOSTRUCTURES FOR SENSING ]]></title_en><user_id>3688</user_id><user_firstLast_name>Mile Ivanda</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-7046</code><acronim><![CDATA[NANOSENS]]></acronim><duration>01.06.2015 - 31.05.2019</duration><status>Završio</status><financ_value>132.191,92 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, Kemija, </scie_field_hr><scie_field_en>Physics, Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>5237, 5879, 4750, 4964, 5104, 4963, 4632, 4296, 5187, 5190, 13452, 13039, </team_members_id><team_members_names><![CDATA[Sanja Vidaček, Maurizio Ferrari, Vedran  Đerek, Lara Mikac, Ozren Gamulin, Marin Kosović, Vedran Đurina, Davor Ristić, Stjepan Lugomer, Tibor Janči, Niyazi Serdar Sariciftci, Marko Škrabić, ]]></team_members_names><keywords_hr><![CDATA[SILICIJ, NANOSTRUKTURE, SENZORI, HIBRIDNE KOMPONENTE, ORGANSKI POLUVODIČI]]></keywords_hr><keywords_en><![CDATA[SILICON, NANOSTRUCTURES, SENSORS, HYBRID COMPONENTS, ORGANIC SEMICONDUCTORS]]></keywords_en><summary_hr><![CDATA[Prijedlog projekta temelji se na našim prethodnim aktivnostima kojima smo naučili pripraviti kvalitetne uzorke nanostrukturiranog silicija. Razvili smo i ideje te stekli znanja i iskustvo za daljnje eksperimentalne tretmane uzoraka kako bi se razvila nova svojstava s ciljem veće konkurentnosti kod određenih primjena.  Projekt se bavi temeljnim fizikalnim i kemijskim svojstvima i primjeni hibridnih silicijevih nanostruktura pripravljanim elektrokemijskim jetkanjem i kemijskom depozicijom iz pare pod niskim tlakom (LPCVD). Projektni prijedlog sadrži četiri međusobno povezana istraživačka zadataka: silicijeve hibridne nanostrukture za plinske senzore;  vrlo osjetljivi detektori za infracrvenu svjetlost; površinski pojačana Ramanova spektroskopija (SERS) u prehrambenoj tehnologiji i sferni optički mikrorezonatori u molekulskoj detekciji. Predloženi zadaci projekta su međusobno povezani preko priprave hibridnih materijala na temelju jeftinog silicija kompatibilnog CMOS tehnologiji u svrhu razvoja navedenih primjena. Za realizaciju predloženih istraživačkih zadataka organiziran je istraživački tim od 14 istraživača (9 znanstvenika i 5 doktorandada) sa 2 znanstvena instituta, 2 fakulteta, 1 instituta u privatnom sektoru i 2 instituta iz inozemstva. Elektrokemijski procesi jetkanja će se koristiti za pripravu silicija s porama odgovarajućih veličina i volumena s mogućom kontrolom od nanometarske do mikrometarske veličine. Različite kemijske metode biti će primjenjene za funkcionalizaciju poroznih silicijevih struktura pri istraživanjima i razvoju detekcije plina, IR senzora i SERS spektroskopije. Nove silicijeve heterostrukture pripravljene LPCVD metodom na sfernim kvarcnim optičkim microrezonatorima istraživati će se obzirom na mogućnosti primjene u detekciji molekula. Strukturna, optička i elektronska svojstva predloženih funkcionalnih silicijskih nanostruktura istraživati će se sa gledišta temeljnih spoznaja kao i u svrhu razvoja specifičnih proizvoda visoke tehnologije potrebnih hrvatskoj industriji.]]></summary_hr><summary_en><![CDATA[The project proposal is based on our prior research activities where we learned how to prepare high quality nanostructured silicon. We have also developed ideas and gained knowledge and experience for further experimental treatments of our samples aimed on development of new properties competitive for specific applications. The project addresses fundamental physics and chemistry, properties and application of silicon hybrid nanostructures prepared by electrochemical anodisation and low pressure chemical vapour deposition (LPCVD). The project proposal consists of four interrelated research tasks: silicon/hybrid nanostructures for gas sensing; low light infrared detection; surface enhanced Raman spectroscopy (SERS) in food technology and spherical optical microresonators in low concentration molecular detection. The proposed tasks are mutually interconnected by the CMOS technology compatible materials production based on inexpensive silicon, and by the search for their specific advanced applications. For the achievement of the proposed research tasks we have organized a team of 14 researchers (9 scientists and 5 PhD students) from 2 scientific institutions, 2 faculties and 1 institution in the private sector and 2 renowned institutions from abroad. Electrochemical processes will be used for construction of tailored pore sizes and volumes in silicon that are controllable on the scale from nano- to micrometers. A number of suitable chemistries will be applied for the functionalization of porous Si surfaces for gas sensing, IR sensors and SERS spectroscopy. The novel silicon heterostructures deposited by the LPCVD method on silica spherical optical microresonators will be investigated for possible applications in molecular sensing. The structural, optical and electrical properties of such functional silicon nanostructures will be examined from the fundamental science point of view as well as for development of specific high-tech products needed by the Croatian industry. ]]></summary_en></project><project>
<id>2963</id><title_hr><![CDATA[Fenotipski i epigenetski odgovor na sušni stres i prilagodljivost populacija hrasta lužnjaka (Quercus robur L.) uzduž gradijenta zemljopisne širine.]]></title_hr><title_en><![CDATA[Phenotypic and Epigenetic Response to Drought Stress and Adaptability of Quercus robur L. Populations along a Latitudinal Gradient]]></title_en><user_id>11185</user_id><user_firstLast_name>Jozo Franjić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-4686</code><acronim><![CDATA[PerdaQuercus]]></acronim><duration>15.06.2015 - 14.06.2019</duration><status>Završio</status><financ_value>128.377,99 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Šumarstvo, </scie_field_hr><scie_field_en>Forestry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet šumarstva i drvne tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Forestry and Wood Technology]]></institution_en><team_members_id>11184, 11214, 11304, 44, 11167, 5275, 11179, 12638, 5607, </team_members_id><team_members_names><![CDATA[Željko Škvorc, Ida Katičić Bogdan, Daniel Krstonošić, Saša Bogdan, Krunoslav Sever, Mladen Ivanković, Martina Temunović, Ivica Čehulić, Maja Morić, ]]></team_members_names><keywords_hr><![CDATA[fenotipska plastičnost, genetska raznolikost, klimatske promjene, ekološka niša, pozadinski rub rasprostranjenosti]]></keywords_hr><keywords_en><![CDATA[phenotypic plasticity, genetic variability, climate change, ecological nishe, rear distribution edge]]></keywords_en><summary_hr><![CDATA[Hrast lužnjak (Quercus robur L.) je jedna od ekonomski najvrijednijih europskih vrsta šumskog drveća. To je ključna klimatogena vrsta u šumama visoke razine bioraznolikosti te stoga ima i neprocjenjivu ekološku i društvenu vrijednost. Opstanak populacija ove vrste u južnoj i jugoistočnoj Europi je ugrožen zbog predviđenih klimatskih ekstrema kao što su dugotrajne suše. Te populacije su dio tzv. &#39;&#39;pozadinskog ruba&#39;&#39; areala vrste, a njihov fenotipski odgovor i sposobnost prilagođavanja klimatskim promjenama nisu dovoljno istraživani. Istraživanje će se provesti na potomstvu i biljnim uzorcima iz europskih populacija uzorkovanih uzduž okolišnog gradijenta zemljopisne širine (sjever-jug). Žarište istraživanja bit će na populacijama iz južnog i jugoistočnog dijela rasprostranjenosti vrste. Cilj nam je usporediti prilagodljivost, epigenetski i fenotipski odgovor na sušni stres južnijih populacija s populacijama iz središnjeg i sjevernog dijela rasprostranjenosti.Glavni znanstveni ciljevi predloženog projekta su određivanje: 1) neutralne genetske raznolikosti i strukture odabranih populacija uzduž gradijenta zemljopisne širine; 2) njihove epigenetske raznolikosti i strukture; 3) njihovog epigenetskog odgovora na dugoročni sušni stres; 4) njihovog fiziološkog, fenološkog, morfološkog i biokemijskog (odnosno fenotipskog) odgovora na sušni stres; 5) njihove adaptivne genetske varijabilnosti, diferencijacije i fenotipske plastičnosti; 6) sadašnje ekološke niše i glavnih okolišnih varijabli koje određuju distribuciju ove vrste 7) buduće rasprostranjenosti vrste uvjetovane scenarijima klimatskih promjena na temelju modeliranja ekološke niše kao i koji će dijelovi sadašnje rasprostranjenosti biti zahvaćeni smanjenjem prikladnosti staništa; 8) razina prilagodljivosti istraživanih populacija usporedbom njihove adaptivne genetske varijabilnosti, fenotipske plastičnosti i epigenetskog odgovora.]]></summary_hr><summary_en><![CDATA[Pedunculate oak (Quercus robur L.) is one of the economically most valuable European forest tree species. It is the keystone climax species of forests which harbour high biodiversity and consequently has priceless ecological and social value. Survival of the specie’s populations in southern and southeastern Europe is endangered by predicted climate extremes such as prolonged drought. These populations are the “rear edge” of the species distribution range and their phenotypic response and adaptive capacity to climate change have not been well studied. Research will be carried out on progenies and plant samples derived from European populations sampled along a latitudinal environmental gradient. The focus of the research will be placed on populations from the southern and southeastern part of the specie’s distribution range. We aim to compare adaptability, epigenetic and phenotypic responses to drought stress of southernmost populations with the populations from the central and northern part of the specie’s distribution range.The main scientific objectives of the proposed project are to determine: 1) neutral genetic diversity and structure of selected pedunculate oak populations along a latitudinal gradient; 2) their epigenetic diversity and structure; 3) their epigenetic response to long-term drought stress; 4) their physiological, phenological, morphological, biochemical and growth (i.e. phenotypic) response to drought stress; 5) their adaptive genetic variability, differentiation and plasticity; 6) current ecological niche preferences and main environmental variables driving its distribution 7) its future distribution under climate change scenarios based on ecological niche modelling and which parts of the contemporary distribution will suffer from decreased habitat suitability induced by climate change; 8) levels of the studied populations adaptability by comparing their adaptive genetic variability, plasticity and epigenetic response.]]></summary_en></project><project>
<id>2964</id><title_hr><![CDATA[Istraživanje utjecaja otpadnih voda iz farmaceutskih industrija na sastav i profil antibiotičke rezistencije izloženih mikrobnih zajednica u slatkovodnim sedimentima]]></title_hr><title_en><![CDATA[Exploring the impact of wastewaters from pharmaceutical industries on the composition and antibiotic resistance profile of exposed microbial communities in freshwater sediments]]></title_en><user_id>12566</user_id><user_firstLast_name>Nikolina Udiković Kolić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2014-09</proposal_call><code>UIP-2014-09-9350</code><acronim><![CDATA[WINAR]]></acronim><duration>01.09.2015 - 31.08.2018</duration><status>Završio</status><financ_value>130.479,79 eur</financ_value><scie_area_hr>Biotehničke znanosti, Prirodne znanosti, </scie_area_hr><scie_area_en>Biotechnical sciences, Natural sciences, </scie_area_en><scie_field_hr>Biotehnologija, Kemija, Biologija, </scie_field_hr><scie_field_en>Biotechnology, Chemistry, Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>6257, 12589, 12743, 3674, 4621, 18946, 18989, 21182, </team_members_id><team_members_names><![CDATA[Irena Vardić Smrzlić, Tamara Jurina, Fabienne Wichmann, Marijan Ahel, Ana Šimatović, Ana Bielen, Juan José González Plaza, Milena Milaković, ]]></team_members_names><keywords_hr><![CDATA[antibiotička rezistencija, mikrobne zajednice, farmaceutska industrija, otpadna voda, sediment, antibiotici, teški metali, rezistom]]></keywords_hr><keywords_en><![CDATA[antibiotic resistance, microbial communities, pharmaceutical industry, wastewater, sediment, antibiotics, heavy metals, resistome]]></keywords_en><summary_hr><![CDATA[Rastuća rasprostranjenost bakterija rezistentnih na antibiotike trenutno je jedna od najozbiljnijih prijetnji zdravlju. Istraživanja pokazuju da kontinuirani unos antibiotika i teških metala u okoliš doprinosi ovom problemu. Selekcijski pritisak nametnut od strane ovih zagađivala promovirao je razvoj i širenje antibiotičke rezistencije među okolišnim i patogenim bakterijama. Iako je otpad farmaceutske industrije prepoznat kao najvažniji točkasti izvor ovih zagađivala u prihvatnom vodenom okolišu, njegov utjecaj na sastav i profil antibiotičke rezistencije izloženih mikrobnih zajednica nije poznat. Kako bi popunili ovaj važan istraživački jaz, predlažemo primijeniti interdisciplinarni pristup koji će se fokusirati na slatkovodne sedimente koji su pod utjecajem otpadnih voda iz dviju lokalnih farmaceutskih industrija. Procijenit ćemo rasprostranjenost antibiotika i teških metala u tim sedimentima i identificirati potencijalne &#39;&#39;vruće točke&#39;&#39; za razvoj rezistencije. Geni koji kodiraju za antibiotičku rezistenciju porijeklom iz &#39;&#39;vrućih točaka&#39;&#39; i referentnih mjesta bit će otkriveni primjenom funkcionalne metagenomike. Ovaj pregled bit će osnova za kvantitativnu studiju koja će uspostaviti prostorno-vremensku poveznicu između industrijskog ispusta i zastupljenosti antibiotičke rezistencije. Ovi podaci, u kombinaciji sa hvatanjem rezistentnih plazmida direktno iz bakterija sedimenta u modelni patogen, bit će kritični za donošenje zaključaka o širenju rezistencije među bakterijama. Kompletno sekvenciranje mobilnih plazmida će nadalje pomoći u identifikaciji novih plazmida koji nose grupirane gene za rezistenciju na antibiotike i teške metale. Konačno, utjecaj ispusta na dinamiku sastava bakterijskih zajednica u sedimentima bit će analiziran Ilumina sekvenciranjem 16S rRNA gena. Vjerujemo da će dobivena saznanja imati vitalne implikacije na razvoj učinkovitih strategija upravljanja kako bi se smanjilo širenje antibiotika i antibiotičke rezistencije preko okolišnih puteva.]]></summary_hr><summary_en><![CDATA[The increasing prevalence of antibiotic resistant bacteria is currently one of the most serious health threats. There is growing evidence that continuous environmental discharge of antibiotics and heavy metals contributes to this issue. The selection pressure imposed by these pollutants has promoted the development and spread of antibiotic resistance among environmental bacteria and pathogens. Although pharmaceutical waste is recognized as the most important point source of these pollutants in the receiving aquatic environment, its impact on the composition and antibiotic resistance profile of exposed microbial communities is not known. To fill this important research gap, we propose to take an interdisciplinary approach focusing on freshwater sediments impacted by wastewaters of two local pharmaceutical industries. We will assess the prevalence of antibiotics and heavy metals in these sediments and identify potential hot spots for resistance evolution. Antibiotic resistance genes from hot spots and reference sites will be discovered using functional metagenomics. This will lay the groundwork for a quantitative study that will establish spatio-temporal relationships between industrial discharge and the occurrence of antibiotic resistance. This, in combination with direct capturing of resistance plasmids from sediment bacteria to a model pathogen will be critical to draw conclusions about the spread of resistance genes among bacteria. Complete sequencing of transferable plasmids will furthermore assist in identifying novel plasmids that carry clustered antibiotic and heavy metal resistance gene loci. Finally, the impact of discharge on dynamics of sediment community composition will be analyzed by Illumina sequencing of 16S rRNA genes. We believe that the obtained knowledge will have vital implications for the development of effective management strategies to reduce the spread of antibiotics and antibiotic resistance determinants via environmental pathways.]]></summary_en></project><project>
<id>2983</id><title_hr><![CDATA[Nutritivna modulacija metabolizma dokozaheksaenske kiseline kod dijabetičke dislipidemije]]></title_hr><title_en><![CDATA[Nutritive modulation of  docosahexaenoic acid metabolism in diabetic dyslipidemia]]></title_en><user_id>5392</user_id><user_firstLast_name>Tomislav Mašek</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-8992</code><acronim><![CDATA[dislipiDHA]]></acronim><duration>01.02.2016 - 31.01.2019</duration><status>Završio</status><financ_value>98.480,32 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Veterinarska medicina, </scie_field_hr><scie_field_en>Veterinary medicine, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Veterinarski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Veterinary Medicine]]></institution_en><team_members_id>12663, 3601, 3611, 12946, 6444, 12484, 13016, 5271, 12628, 13235, 3257, 12450, </team_members_id><team_members_names><![CDATA[Kristina Starčević, Marcela Šperanda, Mislav Đidara, Diana Brozić, Franjo Martinković, Krešimir Bošnjak, Maja Maurić, Snježana Kužir, Luka Krstulović, ivana stolić, Zvonko Stojević, Marina Vranić, ]]></team_members_names><keywords_hr><![CDATA[dokozaheksaenska kiselina, dislipidemija, dijabetes, peroksisomi, oksidacija, prehrana]]></keywords_hr><keywords_en><![CDATA[docosahexaenoic acid, dyslipidemia, diabetes, peroxisomes, oxidation, nutrition]]></keywords_en><summary_hr><![CDATA[Dokozaheksaenske kiseline (DHA) je važna masna kiselina čiji je biokemijski put sinteze  dugo vremena  bio nejasan. Trenutni model pretpostavlja kako nakon serije desaturacija i elongacija u endoplazmatskoj mrežici nastaje C24:6n3 koja odlazi u peroksisom gdje se jednim ciklusom ß-oksidacije skraćuje u 22:6n3 (DHA) i zatim odlazi natrag u endoplazmatsku mrežicu gdje bude esterificirana u odgovarajuće fosfolipide. Količinu DHA u plazmi i tkivima određuje unos masnih kiselina hranom, natjecanje za enzime između n3 i n6 linije masnih kiselina i endogeni metabolizam. Svi ovi čimbenici mogu biti promijenjeni tijekom dijabetesa. Međutim, složenost sinteze trenutno onemogućava točno predviđanje razine DHA u tkivima dijabetičnih životinja.   U projektu ćemo istražiti učinak n3/n6 omjera lipida hrane i direktnog dodatka DHA kod dijabetesa tipa 1 i 2 na metabolizam DHA, oksidaciju u mitohondrijima i peroksisomima i DHA metabolom. Naša pretpostavka je dokazivanje da hranidbena modulacija može umanjiti učinak inzulina kod dijabetičke dislipidemija što može imati veliko značenje u tretmanu dijabetesa. Dodatno ćemo istražiti koji enzimi, uključeni u mitohondrijsku i peroksisomsku   ß-oksidaciju, mogu biti regulirani lipidima hrane.          Istraživanja će biti provedena na štakorima kojima će biti induciran dijabetes tipa 1 i 2 te će dobivati hranidbene tretmane s varirajućih razinama n3/n6   i povećanom koncentracijom DHA. Integriranje rezultata pokusa objasnit će promjene u koncentracijama DHA kod različitih tipova dijabetesa. Istraživanja na subcelularnoj razini omogućit će utvrđivanje učinka dijabetesa na mitohondrijsku i peroksisomsku ß-oksidaciju i metabolizam DHA. Istraživanje metaboloma DHA povezat će prehranu, dijabetes i bioaktivne produkte DHA. Naposljetku, podaci iz cjelokupnog projekta rezultirat će integracijom znanja i boljim razumijevanjem biosinteze DHA.]]></summary_hr><summary_en><![CDATA[Docosahexaenoic acid (DHA) is an important fatty acid which biochemical pathway was enigmatic for a long time. Current model suggests that after the series of desaturation and elongation processes in endoplasmic reticulum C24:6n3 is synthesized, transported to the peroxisome and then shortened to 22:6n3 via one cycle of ß-oxidation and transported back to the endoplasmic reticulum for esterification into the appropriate phospholipids. Plasma and tissue DHA values are determined by dietary intake, competition for enzymes between n3 and n6 line and by the endogenous fatty acid metabolism, which could be dysregulated by diabetes. Nevertheless, the complexity of synthesis currently prevents correct prediction of DHA content in the tissues of diabetic animals.In this project, we will investigate the influence of n-3/n-6 ratio and DHA supplementation in insulin dependent and non-insulin dependent diabetes mellitus on DHA metabolism, mitochondrial and peroxisomal oxidation and DHA metabolome. Our assumption is that nutritional modulation can override insulin influence on diabetic dyslipidemia which could have profound influence on the treatment of diabetes. Additionally we will try to find enzymes of mitochondrial and peroxisomal ß-oxidation which could influence DHA metabolism by nutritional modulation. Trials will be performed on rats with induced diabetes which will receive dietary treatments with different n3/n6 ratios and increased DHA content. Integration of results from experiments will define the behavior of DHA in different types of diabetes. Investigations on subcellular level will allow us to determine the influence of diabetes on peroxisomal and mitochondrial beta oxidation and DHA metabolism. Investigation of DHA metabolome will link nutrition, diabetes and bioactive DHA products. Finally, data from the whole project will result in integration of knowledge and better understanding of DHA biosynthesis.]]></summary_en></project><project>
<id>2984</id><title_hr><![CDATA[Genski polimorfizmi i ishemijski moždani udar u djece]]></title_hr><title_en><![CDATA[Gene polymorphisms and ischemic stroke in children]]></title_en><user_id>3334</user_id><user_firstLast_name>Renata Zadro</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-2047</code><acronim><![CDATA[GENESTROKE]]></acronim><duration>01.10.2015 - 30.09.2019</duration><status>Završio</status><financ_value>106.103,92 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Farmaceutsko-biokemijski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Pharmacy and Biochemistry]]></institution_en><team_members_id>4701, 4057, 4032, 5252, 4686, 13580, 21314, 1302, </team_members_id><team_members_names><![CDATA[Marija Miloš, Margareta Radić Antolic, Ivana Horvat, Marina Pavić, Desiree Coen Herak, Jasna Leniček Krleža, Andrea Čeri, Vlasta Đuranović, ]]></team_members_names><keywords_hr><![CDATA[ishemijski moždani udar,  genski polimorfizmi, trombofilija, djeca, koagulacija]]></keywords_hr><keywords_en><![CDATA[ischemic stroke, genetic polymorphisms, thrombophilia, children, coagulation]]></keywords_en><summary_hr><![CDATA[Cerebrovaskularni poremećaji u djece, iako rijetki, rezultiraju značajnom smrtnošću i dugotrajnim morbiditetom. Pojavnost moždanog udara u djece prema podacima populacijskih studija iznosi 1,23-13,0/100.000 djece/godišnje. Iako je poznato više od 100 rizičnih faktora za nastanak moždanog udara, genetički faktori nisu potpuno istraženi. Za FV Leiden, FII 20210G>A, MTHFR677C>T, manjak protiena C i povišeni lipoprotein (a) pokazano je da igraju ulogu u moždanom udaru u djece. Moždani udar u djece vjerojatno nastaje kao posljedica interakcije više različitih gena i čimbenika okoliša koji zajedno s razlikama u cerebrovaskularnom, neurološkom i koagulacijskom sustavu ograničavaju izravnu ekstrapolaciju istraživanja s odraslih na djecu i opravdaju istraživanja polimorfizama ostalih trombofilijskih faktora. Cilj ovog istraživanja je odrediti prevalenciju genetičkih rizičnih čimbenika u skupini djece s ishemijskim moždanim udarom analizom polimorfizama u i) koagulacijskim faktorima FV (FV Leiden i FV H1299R), FII (20210G>A), FXIII (Val34Leu), beta-fibrinogen (-455G>A) i PAI-1 4G/5G; ii) trombocitni glikoproteinski receptori GPIa (807C>T/873G >A i 52T>C), GPIba (1018C>T, VNTR i (-5C/T Kozak), GPIIb/IIIa (1565T>C – PIA1/A2 i 2622T>G) i GPVI (13254T>C); iii) P-selektin (S290N, N562D, V599L, T715P) i iv) intermedijarni rizični faktori za moždani udar u djece, ACE I/D i Apo E2/E3/E4. Dobiveni rezultati unaprijedit će spoznaju o uključenosti ostalih genetičkih rizičnih čimbenika u etiologiji ishemijskog moždanog udara u djece. Razumijevanje genetičke osnove ishemijskog moždanog udara doprinijet će razvoju i primjeni standardiziranih protokola u dijagnostici, istraživanju, terapiji i procjeni ishoda moždanog udara u djece.]]></summary_hr><summary_en><![CDATA[Cerebrovascular disorders in children, although rare, result in significant mortality and long-term morbidity. The incidence of childhood stroke as reported by population based studies is 1.23-13.0/100 000 children/year. More than 100 risk factors for stroke are recognized but genetic factors are incompletely characterized. FV Leiden, FII 20210G>A, MTHFR 677C>T, protein C deficiency and elevated Lp(a) have been demonstrated to play a role in childhood stroke.  It is likely that stroke in children occurs secondary to interactions between several genes and the environment that, together with age-related differences in cerebrovascular, neurological and coagulation systems limit the direct extrapolation of research from adults to children and justify research of polymorphisms of other thrombophilic factors. The aim of this investigation is to determine the prevalence of genetic risk factors in a cohort of children with ischemic stroke by analysis of polymorphisms in i) coagulation factors FV (FV Leiden and FV H1299R), FII (20210G>A), FXIII (Val34Leu), ß-fibrinogen (-455G>A) and PAI-1 4G/5G; ii) platelet glycoprotein receptors GPIa (807C>T/873G>A and 52T>C), GPIba (1018C>T, VNTR and (-5)C/T Kozak), GPIIb/IIIa (1565T>C – PIA1/A2 and 2622T>G) and GPVI (13254T>C); iii) P-selectin (S290N, N562D, V599L, T715P) and iv) intermediate risk factors for childhood stroke, ACE I/D and Apo E2/E3/E4. The obtained results will enhance knowledge about involvement of other genetic risk factors in the etiology of ischemic stroke in childhood. The understanding of genetic basis of ischemic stroke will contribute to the development and application of standardized protocols for the diagnosis, investigation, therapy and outcome assessment of ischemic stroke in children.]]></summary_en></project><project>
<id>3000</id><title_hr><![CDATA[Definiranje mogućnosti uporabe mini dentalnih implantata (MDI) i njihovi rezultati u in vitro i u kliničkim prospektivnim istraživanjima]]></title_hr><title_en><![CDATA[Defining possibilities of using Mini dental implants (MDI) and their outcomes in vitro and in clinical randomised prospective studies]]></title_en><user_id>7709</user_id><user_firstLast_name>Asja Čelebić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-1218</code><acronim><![CDATA[Mini implantati/ MDI]]></acronim><duration>17.11.2015 - 01.09.2020</duration><status>Završio</status><financ_value>125.423,05 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Dentalna medicina, Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Dental medicine, Clinical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu]]></institution_hr><institution_en><![CDATA[University of Zagreb]]></institution_en><team_members_id>13290, 13236, 7100, 11237, 13209, 13315, 13264, 13199, 13201, 5491, 6148, 13743, 21397, </team_members_id><team_members_names><![CDATA[Denis Vojvodić, Robert Ćelić, Amir Ćatić, Ketij Mehulić, Renata Poljak-Guberina, Dražan Kozak, Damir Modrić, Sanja Peršić, Josip Kranjčić, Goran Batinjan, Irina Filipović Zore, Nikola Petričević, Dino Buković, ]]></team_members_names><keywords_hr><![CDATA[Mini dentalni implantati, standardni implantati, mehanička teastiranja na modelima, klinička prospektivna istraživanja, određivanje indikacija za MDI]]></keywords_hr><keywords_en><![CDATA[Mini dental implants, standard implants, mechanical testing on models, clinical prospective studies, MDI indications]]></keywords_en><summary_hr><![CDATA[Mini dentalni implantati (MDI) su jednokomadni uski implantati za privremenu (ortodoncija, privremeni mostovi) ili za dugoročnu kliničku upotrebu. Prednosti MDI za trajnu kliničku primjenu su u njihovoj niskoj cijeni i jednostavnoj proceduri. Iako na dentalnom tržištu postoje već 10 godina, dokazi o budućim kliničkim istraživanjima za definiranje njihovih kliničkih protokola i njihovom dugoročnom ishodu nedostaju. Stoga planiramo istraživati njihova mehanička svojstva na modelima s obzirom na moment sile prilikom insercije, mogućnost loma prilikom cikličkih opterećenja ili  opterećenja prilikom naprezanja. Situacija slična stanju u ustima  će se simulirati pomoću različitih kosti tvrdoće modela (guste vs kosti niske gustoće) s 2 vrste sluznice  različite širine, te insercijom  1, 2, 3 ili 4 MDI različite širine i dužine za retenciju pokrovne proteze. 3 D printevi služiti će da bi se razvili modeli na kojima će se testirati. Nadalje, buduće kliničke studije koje će se temeljiti na pacijentovoj procjeni ishoda terapije (pomoću psihometrijski odobrenih upitnika) i kliničkih parametara (preživljavanje implantata, komplikacije, razina kosti oko implantata, resorpcija na stražnjim bezubim dijelovima ispod baze proteze, kortikalni indeksi na donjem rubu mandibule, vrijednosti gonion i antegonion udubina, gustoća kostiju u područjima interesa koji će biti izraženi u debljini stepwedga, mjerenje plak, gingiva i kalkulus indeksa, ISQ vrijednosti) će također biti predmetom istraživanja. Podaci će se upoređivati sa onima dobivenim nakon jedne i 3 godine.  Rezulati dobiveni temeljem pacijentove procjene usporediti će se s kliničkim dobivenim parametrima. Nadalje, rezultati dobiveni s obzirom na kliničke parametre kod pacijenata sa MDI (kvaliteta kostiju, količina, gustoća) će se uspoređivati sa podacima kod pacijenata sa potpunim protezama, kod pacijenata sa pokrovnim proteze na 2-standardna implantata te kod  osoba s prirodnim zubala. Također će se proučavati različite mogućnosti retencije proteza (mehanizmi).]]></summary_hr><summary_en><![CDATA[Mini dental implants (MDIs) are one piece slim implants for temporary (orthodontics, temporary bridges) or for a long term clinical use. Advantages of MDIs for a permanent clinical use are their low cost and simple procedures. Although they exist at the dental market for 10 years, evidence based prospective clinical studies for definition of their clinical protocols and long term outcomes are missing. Therefore we plan to study first their mechanical properties on models considering placement torque, fracture torque, possibility of fracture upon cycling loads or strain loads. A situation similar to real one will be simulated by using different bone hardness models (dense vs, low density bone) with 2 different oral mucosa widths, and with insertion of 1, 2, 3 or 4 MDIs of different width and length for overdenture retention. 3D prints will be helpful in model development. Further, prospective clinical studies based on both, patient based outcomes (assessed by psychometrically approved questionnaires) and clinical parameters (implant survival, any complications, bone level adjecent to implants, bone resorption at posterior edentulous sites under a denture base, cortical indices changes at the low border of the mandible, gonion angle and antegonion pitch values, bone density in the region of interest expressed as equvivalents of actual Cu stepwedge thickness attached during exposure, plaque, gingival and calculus indices, ISQ values) will be performed. Baseline data will be compared to a 1-year and 3-year outcomes. Patient based outcomes will be compared with clinical data. Results considering clinical parameters (bone quality, quantity, density) will be compared to similar data in complete denture wearers, in overdenture patients with dentures retained by 2-standard size implants and in individuals with natural dentition. Different denture retention options (mechanisms) will also be studied.]]></summary_en></project><project>
<id>3001</id><title_hr><![CDATA[Postimperijalni narativi u srednjoeuropskim književnostima moderne]]></title_hr><title_en><![CDATA[Postimperial narratives in Central European Literatures of the Modern Period]]></title_en><user_id>7997</user_id><user_firstLast_name>Marijan Bobinac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-2307</code><acronim><![CDATA[Postimperial]]></acronim><duration>01.06.2015 - 31.05.2019</duration><status>Završio</status><financ_value>62.349,19 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filologija, Povijest, </scie_field_hr><scie_field_en>Philology, History, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>12586, 3566, 12609, 12579, 6503, 21419, 17727, 25305, 25194, 25245, 17728, </team_members_id><team_members_names><![CDATA[Svjetlan Lacko Vidulić, Milka Car, Davor Dukić, Magerski Christine, Jelena Spreicer, Daniela Finzi, Endre Hars Hars, Wolfgang Müller-Funk, andrea seidler, Clemens Ruthner, Johann Georg Lughofer, ]]></team_members_names><keywords_hr><![CDATA[Postimperijalni narativi, srednjoeuropske književnosti: hrvatska, austrijska, mađarska, moderna, dihotomija centar/periferija, Habsburg postcolonial]]></keywords_hr><keywords_en><![CDATA[Postimperial narratives, Central European literatures: Croatian, Austrian, Hungarian, modern period, dichotomy center/periphery, Habsb. postcolonial]]></keywords_en><summary_hr><![CDATA[Naš projektni prijedlog, polazeći od teorijskog pristupa tzv. imperijalnih i postimperijalnih studija, istraživat će dodire i preklapanja u srednjoeuropskim kulturama sjećanja, a napose točke preklapanja u (zajedničkim) strukturama književne produkcije na tom području. Posebna će se pozornost pritom posvetiti Habsburškoj monarhiji, odnosno njezinim zemljama sljednicama u posljednjim dvama stoljećima, tj. u razdoblju od početaka procesa nastajanja modernih nacija pa sve do rasapa multietničkih državnih formacija, tj. starih imperija srednje i jugoistočne Europe, i nastanka novih nacionalnih država.Termin imperij, ključan pojam našeg istraživanja, preuzet je iz geopolitičke povijesti i može se primijeniti i na druge značajne državne strukture tog tipa (Osmansko, Rusko, Njemačko carstvo), relevantne u spomenutom vremenskom i prostornom kontekstu. Koncept implicira postojanje složene mreže društvenih, političkih i gospodarskih odnosa unutar tih državnih formacija, odnosa koji nastaju i posreduju se kroz konstrukcije &#39;kulturne razlike&#39; i asimetričnih odnosa moći. Imperij se može shvatiti kao kompleksna kulturna &#39;priča&#39; koju stvaraju političke i kulturne elite: kao neka vrsta narativnog konstrukta koji se u različitim kontekstima strukturira na različite načine, služeći pritom opisu ili objašnjenju određenih pojava ili odnosa. Stoga se ne samo nacionalne, nego i supranacionalne, tj. imperijalne kulture trebaju proučavati kao &#39;pripovjedne zajednice&#39;, strukture koje se međusobno razlikuju ponajprije po svome pripovjednom &#39;rezervoaru&#39;.Osnova istraživanja bit će književnost, kulturni medij koji raspolaže jedinstvenim mogućnostima reprezentacije, afirmacije i subverzije konstrukcija kulturnog sjećanja i procesa stvaranja individualnih i kolektivnih identiteta. U tom kontekstu posebna će pažnja biti posvećena sljedećim pitanjima: 1) kako procesi nacionalne homogenizacije i imperijalne težnje funkcioniraju u mediju književnosti, 2) na koji se način oni prožimlju i sukobljavaju, te 3) kako se oni pritom instrumentaliziraju za konkretne političke, ideološke ili estetske ciljeve.]]></summary_hr><summary_en><![CDATA[Our research project situates itself in the field of Imperial and Post-Imperial Studies. It will investigate overlaps and interferences between different cultures of memory in Central Europe, along with possible points of convergence in (joint) structures of literary production. Special attention will be paid to the Habsburg Monarchy and its successor states in the last two centuries – from the beginnings of the modern nation building process to the subsequent disintegration of multi-ethnic state formations.The term ‘empire’, being key to our research, is borrowed from geopolitical historiography and also applies to other empires in the region, which are relevant in the aforementioned temporal and spatial context. The concept implies a complex network of social, political and economic relations within the state, established and ‘translated’ through constructions of ‘cultural difference’ and asymmetrical power relations. Thus, ‘empire’ can also be understood as a complex cultural ‘story’ told by the political and cultural stakeholders: a type of narrative construct structured differently in different contexts and often used to describe or explain certain social / historical facts. Accordingly, not only national, but also supranational, i.e. imperial, cultures should be studied as ‘narrative communities’ differing from each other mainly through their cultural story-telling reservoirs.In order to exemplify this, our research project will be based on the study of literature as a medium of culture with the unique capacity to represent, affirm and undermine constructions of cultural memory and processes of both individual and collective identity formations. For conclusive results, we will address the following research questions: 1) how processes of national homogenization and imperial claims function in the medium of literature, 2) how they come in contact and, 3) how they can be instrumentalized for concrete political, ideological or aesthetic purposes.]]></summary_en></project><project>
<id>3002</id><title_hr><![CDATA[Imunosne i regenerativne implikacije korozije dentalnih materijala u djece i adolescenata]]></title_hr><title_en><![CDATA[Immunological and regenerative implications of corrosion of dental materials in children and adolescents ]]></title_en><user_id>77</user_id><user_firstLast_name>Stjepan Špalj</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-7500</code><acronim><![CDATA[IMUNODENT]]></acronim><duration>01.12.2015 - 30.11.2019</duration><status>Završio</status><financ_value>127.735,09 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo, Tehničke znanosti, </scie_area_hr><scie_area_en>Biomedicine and health sciences, Technological sciences, </scie_area_en><scie_field_hr>Dentalna medicina, Kemijsko inženjerstvo, Strojarstvo, Kliničke medicinske znanosti, Javno zdravstvo i zdravstvena zaštita, </scie_field_hr><scie_field_en>Dental medicine, Chemical engineering, Mechnical engineering, Clinical sciences, Public health and health services, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Medicine]]></institution_en><team_members_id>3799, 5203, 104, 99, 12407, 11286, 11287, 4798, 11283, 5125, 4260, 3866, 13366, 3810, 25209, </team_members_id><team_members_names><![CDATA[Zorana Ivanković Buljan, Helena Otmačić Ćurković, Magda Trinajstić Zrinski, Višnja Katić, Elitza Petkova Markova-Car, Aleksandar Bulog, Sandra Peternel, Koviljka Matušan Ilijaš, Ines Musa Trolić, Andrej Pavlić, Marijana Rinčić Mlinarić, Jelena Prpić, Jasmina Primožič, Miranda Muhvić Urek, Martina Žigante, ]]></team_members_names><keywords_hr><![CDATA[allergy, antibiotic resistance, nickel exposure, titan exposure, corrosion]]></keywords_hr><keywords_en><![CDATA[allergy, antibiotic resistance, nickel exposure, titan exposure, corrosion]]></keywords_en><summary_hr><![CDATA[Pomicanje zubi napravama baziranim na niklu i titanu ima veliki osteogeni potencijal i može regenerirati deficijentne dijelove alveolarne kosti i gingive te rehabilitirati narušene okluzijske odnose i žvačnu funkciju pacijenta. Zbog dugotrajnosti takve terapije paralelno se primjenjuju postupci i materijali za prevenciju te regeneraciju oštećene cakline i oralnih sluznica. Usna šupljina može se smatrati galvanskim člankom gdje su dentalne slitine elektrode, a elektrolit čine slina te oralni preventivni i regeneracijski agensi. Interakcija uzrokuje koroziju, smanjenje elastičnosti naprava, produkciju prevelikih sila, poremećaj regeneracije tikiva i nepopravljive štete na korijenu zuba, parodontu i kosti. Tijekom dugotrajne eksponiranosti otpušteni korozivni produkti u okolnim tkivima te transportirani slinom i krvlju mogu izazvati cijeli niz nusefekata. Alergije su danas sve češće i javljaju se sve ranije, a posebna skupina su djeca i mladi adolescenti u periodu pubertetskog rasta kada se razvija i imunološki sustav. Nikal je dugo poznati alergen i prisutan je u brojnim dentalnim legurama. Alergija na nikal događaje su u do 28.5% populacije i ne može se više smatrati niskim potencijalnim rizikom. U posljednje vrijeme reportira se i alergija na titan, za koji se smatralno da je biokompatibilan, a izloženi su mu brojni pacijenti s endoprotezama kuka, stentovima, dentalnim implantatima i ortodontskim napravama. Alergija na titan može biti odgovorna za neobjašnjene slučajeve neuspjeha i odbacivanja dentalnih implantata. Nikal i titan mogu uzrokovati rezistenciju bakterija na antibiotike što može stvarati probleme u terapiji niza infekcija koje su češće u djece i adolesceanta. Cilj je ovog projekta ispitati u kojoj mjeri i kojim mehanizmima korozija dentalnih materijala baziranih na niklu i titanu izaziva prethodno navedene biološke učinke.]]></summary_hr><summary_en><![CDATA[Tooth movement, based on nickel-titanium appliance, has great osteogenic potential, it can regenerate deficient alveolar bone sites and gingiva, rehabilitate deficient occlusal relationships and masticatory function. Due to prolonged therapy materials and techniques for prevention and regeneration of damaged enamel and oral tissues are concurrently used. Oral cavity can be considered as a galvanic cell, where saliva is electrolyte and dental alloys and oral agents are galvanic coupling components. Decreasing elasticity of orthodontic wires due to intraoral corrosion can produce excessive forces and therefore can disturb regeneration of tissues and irreparable damage to root and surrounding periodontium and bone. Due to long-term exposure corrosive products are released into adjacent tissues, saliva and blood. There from a number of undesired side effects can develop. Nowadays, the allergies occur more often and onset earlier during a lifetime. Children and young adolescents are undergoing pubertal growth, changes and maturation of immune system and particular attention should be paid to their exposure. Nickel has been well known allergen, present in many dental alloys. Nickel allergic hypersensitivity occurs in up to 28.5% of the population and it cannot be considered a low potential risk. Lately, allergic reactions to titanium were reported in patients with endoprosthesis and dental implants, contrary to the previously established biocompatibility. The occurrence of an allergy to titanium could be responsible for successive unexplained cases of failure of dental implants. Nickel and titan can enhance resistance of some bacteria to antibiotics which can produce problems in treatment of several infections that are more common in children and adolescents. The aim of this project is to explore to what extent and by which mechanisms does corrosion of dental materials based on nickel and titan produce above mentioned biological effects.]]></summary_en></project><project>
<id>3004</id><title_hr><![CDATA[Razvoj evolucijskih postupaka za karakterizaciju ponašanja bioloških tkiva]]></title_hr><title_en><![CDATA[Development of evolutionary procedures for characterization of biological materials behavior]]></title_en><user_id>11229</user_id><user_firstLast_name>Marina Franulović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-4982</code><acronim><![CDATA[BIOMAT]]></acronim><duration>01.10.2015 - 30.09.2019</duration><status>Završio</status><financ_value>95.228,62 eur</financ_value><scie_area_hr>Tehničke znanosti, Biomedicina i zdravstvo, </scie_area_hr><scie_area_en>Technological sciences, Biomedicine and health sciences, </scie_area_en><scie_field_hr>Strojarstvo, </scie_field_hr><scie_field_en>Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Tehnički fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Engineering]]></institution_en><team_members_id>12834, 12813, 12820, 13022, 13078, 13011, 13337, 22633, 24813, </team_members_id><team_members_names><![CDATA[Robert Basan, Kristina Marković, Tea Marohnić, Ivan Prebil, Ana Trajkovski, Senad Omerović, Simon Krašna, Stjepan Piličić, Robert Kunc, ]]></team_members_names><keywords_hr><![CDATA[biološki materijali, karakterizacija materijala, materijalni model, materijalni parametri, genetski algoritam]]></keywords_hr><keywords_en><![CDATA[biological materials, material characterization, material model, material parameters, genetic algorithm]]></keywords_en><summary_hr><![CDATA[U inženjerstvu sve se veća pažnja posvećuje poboljšanju značajki konvencionalnih i razvoju inovativnih materijala. Iako je istraživanje materijala uvelike usmjereno na metale, polimere, staklo, keramiku, kompozite itd., sve veći interes posvećuje se biološkim sustavima i materijalima (školjke, kosti, paukova svila, mišići itsl.) zbog njihovih svojstava koje uvelike nadvisuju one konvencionalnih materijala. Ponašanje i modeliranje bioloških materijala je kompleksno, ali se kao i modeliranje konvencionalnih materijala bazira na poznavanju i eksperimentalnom određivanju njihovih karakteristika. Pored materijalnog modela za opisivanje ponašanja materijala, osnovni preduvjet za modeliranje je identifikacija materijalnih parametara. Prethodno je ustanovljeno da je za identifikaciju parametara bioloških materijala potrebnih za modeliranje njihovog ponašanja preporučljivo primijeniti evolucijske metode, a posebno genetski algoritam. U okviru projekta karakterizirat će se i modelirati ponašanje vratnih ligamenata ljudske kralježnice na osnovi podataka dobivenih eksperimentima. Odabran je hiperelastični materijalni model koji se može koristiti i za kompresibilne i nekompresibilne materijale. Kako bi se na što efikasniji način dobile potrebne vrijednosti materijalnih parametara, razvit će se tehnika određivanja parametara temeljena na genetskom algoritmu. U cilju optimizacije procedure dobivanja parametara zadanog materijala, razvit će se procedura složenog genetskog algoritma te njegovi operatori, uz primjenu adekvatne funkcije cilja optimizacijskog postupka.Zbog fleksibilnosti i robusnosti predložene metodologije karakterizacije materijala, moguća je njena primjenjivost i na karakterizaciju ponašanja i drugih nekonvencionalnih i inovativnih materijala kompleksnog ponašanja. U tu svrhu prikupit će se i sistematizirati rezultati relevantnih publiciranih eksperimentalnih ispitivanja materijala te stvoriti pretpostavke za karakterizaciju drugih inovativnih materijala.]]></summary_hr><summary_en><![CDATA[In engineering great attention is paid to enhancing the properties of conventional and development of innovative materials. Although the research is largely focused on metals, polymers, glass, ceramics, composites, etc.., increasing interest is devoted to biological systems and materials (shells, bone, spider silk, muscle or similar) due to their characteristics that are significantly above those of conventional materials.Behavior and modeling of biological materials is complex, but as the modeling of conventional materials, it is based on the knowledge and experimental determination of their characteristics. To describe the behavior of materials, beside material model, the basic prerequisite is the identification of material parameters.It was found that for the identification of parameters of biological materials necessary for the modeling of their behavior, it is advisable to apply the evolutionary methods, especially genetic algorithm.In the project, the behavior of the neck ligaments of human spine will be characterized and modelled based on data obtained by experiments. A hyperelastic material model that can be used for compressible and incompressible materials is selected for that puprose. In order to more efficiently produce the required values of material parameters, a technique for determining the parameters based on genetic algorithm will be developed. In order to optimize the procedure to obtain the parameters specified materials, complex genetic algorithm and its operators will be developed, applying the appropriate objective function optimization procedure.Because of it&#39;s flexibility and robustness, the proposed methodology for the materials characterization is expected to be applicable to the characterization of other non-conventional and innovative materials of complex behavior. To this end, relevant published experimental results will be collected and systematized in order to create the basis for the characterization of other innovative materials.]]></summary_en></project><project>
<id>3005</id><title_hr><![CDATA[Molekularni mehanizmi ugradnje homolognih i heterolognih proteina u staničnoj stijenci kvasca i njihova primjena u biotehnologiji]]></title_hr><title_en><![CDATA[Molecular mechanisms for incorporation of homologous and heterologous proteins in the yeast cell wall and their application in biotechnology]]></title_en><user_id>359</user_id><user_firstLast_name>Vladimir Mrša</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-2837</code><acronim><![CDATA[CEWAPROT]]></acronim><duration>01.09.2015 - 31.08.2019</duration><status>Završio</status><financ_value>122.834,96 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Biotehnologija, </scie_field_hr><scie_field_en>Biotechnology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Food Technology and Biotechnology]]></institution_en><team_members_id>3258, 4377, 5726, 3284, 4764, 12966, 4031, 13195, 13087, 25089, </team_members_id><team_members_names><![CDATA[Renata Teparić, Igor Stuparevic, Slobodan Barbarić, Iva Grabarić Andonovski, Damir Iveković, Marina Palčić, Antonija Grbavac, Ksenija Lopandić, Krešimir Gjuračić, Mateja Lozančić, ]]></team_members_names><keywords_hr><![CDATA[stančna stijenka kvasca, proteini stanične stijenke, lokalizacija proteina, heterologna ekspresija, izlaganje na staničnoj površini, genetička imobili]]></keywords_hr><keywords_en><![CDATA[yeast cell wall, cell wall proteins, protein localization, heterologous expression, surface display, genetic immobilization]]></keywords_en><summary_hr><![CDATA[Stanična stijenka kvasca sastoji se od unutrašnjeg sloja glukana na koji su s vanjske strane vezani manoproteini. Velika je raznolikost među proteinima stijenke, ne samo u strukturama i aktivnostima, nego i u načinu na koji su ugrađeni u stijenku. Neki od njih vezani su nekovalentno, neki kovalentno putem esterske veze nestabilne u lužinama, a neki također kovalentno, ali putem GPI-sidra i beta-1,6-glukana. Za najzastupljeniji nekovalentno vezani protein, Scw4p, nađeno je da je na glukan djelomično vezan i kovalentno, još nepoznatom vrste veze. Jedan od ciljeva ovog projekta je objasniti molekularnu prirodu te veze. Osim toga, za nekoliko proteina stijenke, uključujući i Scw4p nađeno je da su proteolitički procesirani. Drugi cilj ovog projekta bio bi ispitati koje proteaze cijepaju Scw4p i koji je fiziološki značaj te modifikacije.Poznavanje mehanizama ugradnje proteina u stijenku kvasca upotrijebit će se za ugradnju i izlaganje na površini heterolognih proteina eksprimiranih u kvascu. Pripremit će se novi plazmidi u tu svrhu, za ekspresiju i ugradnju proteina u stijenku kvasaca S. cerevisiae i P. pastoris. Analizirat će se i stanične stijenke više drugih kvasaca izoliranih iz različitih habitata kako bi se ispitala mogućnost da oni budu novi domaćini za izlaganje proteina.Kako već postojeći, tako i novoistraženi genetički sustavi upotrijebit će se za izlaganje na površini šest enzima biokemijskog puta za degradaciju S-triazina iz bakterije Pseudomonas ADP. Istražit će se primjena dobivenih kvaščevih sojeva za degradaciju ovog široko korištenog herbicida.Druga potencijalna primjena ove metodologije obuhvatit će izlaganje nekoliko ksiloza reduktaza iz različitih kvasaca i primjenu dobivenih sojeva u proizvodnji ksilitola iz ksiloze uz odgovarajuću elektrokemijsku regeneraciju potrebnog NAD(P)H. Ispitat će se i potencijal te metode za primjenu u biosenzorima.]]></summary_hr><summary_en><![CDATA[Yeast cell wall consists of an inner layer of beta-1,3-glucan to which mannoproteins are attached. There is a pronounced variability among yeast cell wall proteins not only in their structures and activities, but also in the way they are incorporated into the wall. Some of them are attached non-covalently, some are linked covalently through an alkali labile ester linkage, and some are attached through GPI anchors and beta-1,6-glucan. The most abundant non-covalently attached protein Scw4p was found to be partly also covalently attached to glucan by a so far unknown linkage. One of the goals of this project is to explain the molecular nature of this linkage. Several cell wall proteins including Scw4p were found to be proteolytically processed. The second goal of the proposed project is to investigate which protease cleaves Scw4p and what is the physiological significance of this modification.Our comprehension of molecular mechanisms for incorporation of proteins in the yeast cell wall can be used for surface display of heterologous proteins expressed in yeasts. New plasmids will be created for this purpose for expression and wall incorporation of proteins in S. cerevisiae and P. pastoris. Besides, cell walls of several other non-Saccharomyces yeasts isolated from different habitats will be analysed to search for other potential hosts for surface display of proteins.Both existing, and newly investigated genetic systems will be used for surface display of six enzymes of the S-triazine complete degradation pathway from Pseudomonas ADP. Application of obtained strains in degradation of this world-wide commonly used herbicide will be explored. Described methodology would be used for surface display of several xylose reductases from several yeasts and the application of the obtained strains for enzymatic production of xylitol, combined with electrochemical regeneration of the necessary NAD(P)H. Potential of this method for application in biosensing will also be explored.]]></summary_en></project><project>
<id>3007</id><title_hr><![CDATA[Motorička znanja djece predškolske dobi: Osnivanje Nacionalnog centra za motorički razvoj]]></title_hr><title_en><![CDATA[Motor skills in preschool children: Foundation of the National center for motor development]]></title_en><user_id>12537</user_id><user_firstLast_name>Sanja Šalaj</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2014-09</proposal_call><code>UIP-2014-09-5428</code><acronim><![CDATA[MZDPD]]></acronim><duration>01.09.2015 - 31.08.2019</duration><status>Završio</status><financ_value>18.196,30 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Kineziologija, </scie_field_hr><scie_field_en>Kinesiology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Kineziološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Kinesiology]]></institution_en><team_members_id>12731, 12593, 7521, 1493, 13377, 13467, 4051, </team_members_id><team_members_names><![CDATA[Vatroslav Horvat, Milivoj Jovancevic, MAJA VUKELJA, Frane Žuvela, Dragan  Milanović, Biljana Trajkovski, Vilko Petrić, ]]></team_members_names><keywords_hr><![CDATA[temeljna kretna znanja, sposobnost, tjelesna aktivnost, vrtić, vježbanje ]]></keywords_hr><keywords_en><![CDATA[fundamental movement, physical abilities, toddler, exercise, physical activity, kindergarten]]></keywords_en><summary_hr><![CDATA[Kompetencija u području temeljnih motoričkih znanja poput trčanja, skakanja i bacanja pridonosi dječjem tjelesnom, kognitivnom i socijalnom razvoju i smatra se temeljem za aktivan život. Pozitivno je povezana sa zdravstvenim dobrobitima, razinom tjelesne aktivnosti djece, a negativno s nepovoljnim težinskim statusom: prekomjernom težinom i pretilošću (Lubans i sur., 2010).  cilj ovog projekta je osnivanje Nacionalnog centra za motorički razvoj pri Kineziološkom fakultetu Sveučilišta u Zagrebu. Postavljeni su znanstveni ciljevi i projektni zadaci po godinama koji će omogućiti: a) vrednovanje motoričkih znanja djece predškolske dobi u Republici Hrvatskoj, b) utvrđivanje razlika u motoričkim znanjima djece različitog stupnja tjelesne aktivnosti i uključenosti u programe vježbanja, c) definiranje povezanosti motoričkog razvoja sa ostalim domenama razvoja djeteta (socioemocionalni i govorno-jezični razvoj), d) utjecaj roditeljskog interesa prema sportu i stupnja njihove tjelesne aktivnosti na razinu motoričkih znanja djece i e) utvrđivanje utjecaja različitih trenažnih programa na motorička znanja i sposobnosti djece predškolske dobi. U istraživanju će sudjelovati 1500 dječaka i djevojčica u rasponu od 3 do 7 godina i njihovi roditelji iz različitih dijelova Republike Hrvatske. Mjerenje će se provoditi u dva dijela. Prvi dio predstavlja ispunjavanje anketnog upitnika od strane roditelja, a drugi dio testiranje motoričkih znanja putem dva seta testova za procjenu motoričkog statusa (“Test of Gross Motor Development“ i ˝Bruininks-Oseretsky Test of Motor Proficiency˝). Dobiveni podaci predstavljali bi temelj za definiranje normativnih vrijednosti i daljnja istraživanja motoričkog statusa djece u Republici Hrvatskoj te izradu strategije poticanja motoričkog razvoja kroz različite programe i znanstvene aktivnosti utemeljenog Nacionalnog centra za motorički razvoj.]]></summary_hr><summary_en><![CDATA[Competence in the field of fundamental movement skills such as running, jumping and throwing contributes to children&#39;s physical, cognitive and social development. It is considered to be the basis for an active lifestyle. Motor proficiency is positively associated with health benefits, level of physical activity of children, and negatively associated with body weight status (obesity) (Lubans et al., 2010). Final objective of this project is the establishment of the Croatian National Centre for Motor Development at the Faculty of Kinesiology, University of Zagreb. The set of scientific objectives and project assignments per year will allow: a) the evaluation of motor skills of preschool children in the Republic of Croatia, b) the determination of differences in motor skills of preschool children who are involved in different degrees of physical activity and exercise programs, c) the definition of the connection of motor development with the other domains of children development (socio-emotional and language), d) the determination of impact of parental interests in sports and  their physical activity levels on children&#39;s motor skills, and e) the assessment of different training programs effects on motor skills and abilities of preschool children. The study will embrace 1,500 boys and girls aged 3 to 7 years and their parents from different areas of the Republic of Croatia. Subjects’ testing will be conducted in two parts. First, the parents will fill out the questionnaire, and second, the children’s motor skills will be measured through two sets of motor development and motor proficiency tests. The resulting data would represent a foundation for the normative values and further research on motor status of children in the Republic of Croatia. Also, the findings will be the starting point for the development of strategies promoting motor development through various programs and research activities of the newly established Croatian National Center for Motor Development.]]></summary_en></project><project>
<id>3009</id><title_hr><![CDATA[Profesionalizam u zdravstvu]]></title_hr><title_en><![CDATA[Professionalism in Health Care]]></title_en><user_id>776</user_id><user_firstLast_name>Ana Marušić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-7672</code><acronim><![CDATA[ProHealth]]></acronim><duration>01.10.2015 - 30.09.2019</duration><status>Završio</status><financ_value>99.655,58 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Javno zdravstvo i zdravstvena zaštita, Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Public health and health services, Clinical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Split School of Medicine]]></institution_en><team_members_id>1016, 2713, 772, 12675, 5404, 874, 12670, 767, 4435, 12768, 5258, 12730, 937, 1046, 4935, 777, 4510, 1418, 25225, </team_members_id><team_members_names><![CDATA[Lana Barać, Ana Jerončić, Mario Malički, Julije Meštrović, Tina Poklepović Peričić, Shelly Melissa Pranić, Dario Sambunjak, Davorka Vrdoljak, Elizabeth Wager, Ivančica Pavličević, Davor Lukšić, Karmela Krleža-Jerić, Ana  Utrobičić, Irena Zakarija-Grković, Dalibora Behmen, Matko Marušić, Livia Puljak, Darko Hren, Marin Viđak, ]]></team_members_names><keywords_hr><![CDATA[profesionalizam, zdravstvena skrb, profesionalci, integritet, izvrsnost, odgovornost, transparencija]]></keywords_hr><keywords_en><![CDATA[professionalism, health care, students, professionals, integrity, excellence, accountability, transparence]]></keywords_en><summary_hr><![CDATA[Predloženi projekt ima za cilj istraživanje izvrsnosti, odgovornosti i integriteta/transparencije kao atributa profesionalizma koji su relevantni za zdravstvenu skrb utemeljenu na dokazima, gdje je profesionalizam široko definiran kao predanost izvršavanju profesionalne zadaća, pridržavanju etičkih principa i osjetljivosti za pacijentovu dobrobit. Prva istraživačka tema projekta usmjerena je na profesionalizam u studenata. Istražit ćemo determinante profesionalnog razvoja studenata, kao i okružje za razvoj profesionalne izvrsnosti i integriteta. Temeljem nalaza iz tog dijela istraživanja, razvit ćemo i testirati intervencije za poticanje razvoja profesionalizma tijekom studija. Druga istraživačka tema usmjerena je na profesionalizam u praksi zdravstvene skrbi. Prvo ćemo usporediti okvire za profesionalnu izvrsnost i integritet, uključujući i dokaze dostupne zdravstvenim profesionalcima i njihovu translaciju u praksi. Temeljem nalazi iz tog dijela istraživanja, razvit ćemo i testirati intervencije za poboljšanje profesionalne prakse. Pristup svakom specifičnom cilj istraživanja uključit će 1) mapiranje trenutnog znanja i identifikacija područja s manjkavim znanjem, 2) uporabu adekvatnih istraživačkih ustroja i metodologija, 3) sinteza rezultata istraživanja u eksplanatorne teorije i modele i 4) razvoj i diseminacija aplikacija važnih za javnu politiku i pristup zdravstvenoj skrbi. Rezultati predloženih istraživanja pridonijet će boljem razumijevanju kako se profesionalizam razvija tijekom obrazovanja i prakse u zdravstvenoj skrbi. Razvojem i testiranjem novih intervencija za poticanje razvoja profesionalizma, projekt će donijeti dokaze za promicanje kurikularnog i cjeloživotnog učenja i za promjenu politike zdravstvene skrbi, kao i donijeti važne ekonomske i javnozdravstvene koristi.]]></summary_hr><summary_en><![CDATA[The proposed project aims to study excellence, accountability and integrity/transparency as attributes of professionalism which are most relevant for evidence-based healthcare, where professionalism is broadly defined as commitment to carrying out professional responsibilities, adherence to ethical principles and sensitivity to patient populations. The first research theme addresses professionalism in healthcare students. We will investigate the determinants of professional development in students, as well as the environment for the development of professional excellence and integrity. Based on the findings from this research, we will develop and test interventions for teaching professionalism in health curricula. The second research theme addresses professionalism in healthcare practice. We will first describe the framework for professional excellence and integrity, including the evidence available to healthcare practitioners and its translation to practice. Based on research results, we will develop and test interventions for professional practice. Each specific objective will include: 1) mapping of current research results and identification of knowledge gaps, 2) using appropriate research design and methodology, 3) synthesising research results into explanatory theories and models, and 4) developing and disseminating applications relevant for policy and public use. Results from the proposed research will contribute to better understanding of how professionalism develops during healthcare education and practice. By developing and testing new interventions for professionalism, the project will provide evidence for the advancement of curricular and life-long learning and policy changes in healthcare, as well as bring important economic and public health benefits.]]></summary_en></project><project>
<id>3010</id><title_hr><![CDATA[Model mjerenja efikasnosti javno zdravstvenih usluga]]></title_hr><title_en><![CDATA[A model for measuring the efficiency of public health services]]></title_en><user_id>245</user_id><user_firstLast_name>Neda Vitezić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-8235</code><acronim><![CDATA[MEPHS]]></acronim><duration>19.05.2015 - 18.05.2020</duration><status>Završio</status><financ_value>38.114,77 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, </scie_field_hr><scie_field_en>Economy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Ekonomski fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Economics and Business]]></institution_en><team_members_id>5114, 7120, 6438, 13419, 6371, 13765, 6723, 22832, 4913, 5391, 25556, 1068, 22489, </team_members_id><team_members_names><![CDATA[Vladimir Mićović, Đulija Malatestinić, Lidija Pavica Pernar, Mirjana Grčić Fabić, Mirjana Zukić, Stanka Setnikar Cankar, Alemka Šegota, Antonija Petrlić, Suzana Janković, Danijela Rabar, Danijela Čošić, Željko Linšak, Ana Bobinac, ]]></team_members_names><keywords_hr><![CDATA[javno zdravstvene usluge, efikasnost, mjerenje, DEA,BSC]]></keywords_hr><keywords_en><![CDATA[public health services, efficiency, measurement, DEA, BSC]]></keywords_en><summary_hr><![CDATA[Predmet istraživanja je mjerenje efikasnosti javno zdravstvenih usluga u Hrvatskoj koje se provodi kroz razne programe i projekte zavoda za javno zdravstvo (prevencija bolesti, ekologija, socijalna medicina, mikrobiologija i sl.). Osnovni cilj istraživanja je predložiti model za mjerenje efikasnosti tih usluga a koji bi bio primjenjiv i na ostale usluge u zdravstvu ali i na druge javne usluge. (npr. u bolnicama, lokalnoj samoupravi, sveučilištu i sl.). Model će se temeljiti na kombinaciji dviju metoda (DEA-BSC) koje su pogodne za mjerenje efikasnosti i efektivnosti raznovrsnih javnih usluga. DEA metoda se tradicionalno koristi za neprofitne organizacije gdje slične organizacijske jedinice djeluju s različitim ulaznim/izlaznim veličinama i gdje u pravilu nema zarade. BSC je metoda kojom se potiče strateško razmišljanje i ocjenjuje učinkovitost postavljenih ciljeva. Kombinacija DEA i BSC metode je relativno nova ideja i koristi se za utvrđivanje uzročno posljedičnih veza posebno kod neefikasnih jedinica. Model će se razraditi na primjeru Nastavnog zavoda za javno zdravstvo Primorsko goranske županije koje ima 48 organizacijskih jedinica. Ciljevi projektnog prijedloga su sljedeći: utvrditi relativnu efikasnost svake organizacijske jedinice i predložiti poboljšanja za neefikasne organizacijske jedince (projekcija na efikasnu granicu–DEA metoda), definirati cjelovit model (integracija DEA i BSC) za mjerenje efikasnosti po pojedinim perspektivama unutar BSC okvira sa svrhom mjerenja efektivnosti ostvarivanja postavljenih ciljeva. ]]></summary_hr><summary_en><![CDATA[The subject of this research is to measure the efficiency of public health services in Croatia, which is carried out through various programs and projects of Public Health Institutes (prevention of diseases, ecology, social medicine, microbiology, etc.). The main goal of the research is to propose a model of measuring the efficiency of public health services that can also be applied to other activities in healthcare and other public services such as local government, universities etc. The model will be based on the combination of two methods (DEA and BSC) that are suitable for measuring the efficiency and effectiveness of various public services. DEA method is traditionally used for non profit organizations where similar units operate with different input/output basically without any income. BSC is a method that encourages strategic thinking and evaluates the effectiveness of set goals. The combination of DEA and BSC is relatively a new approach and is used to identify the cause and effect relationships especially within inefficient units. The model will be developed for the Teaching Institute of the Public Health of Primorje-Gorski Kotar County which has 48 organization units (DMUs). The objective of the project proposals are as follows: to determine relative efficiency of each organization unit and suggest improvements for the inefficient ones (projection on the efficient frontier-DEA method), to define an integrative model (integration of DEA and BSC) for measuring the efficiency of individual perspectives within BSC framework with the aim to assess the effectiveness of achieving goals. ]]></summary_en></project><project>
<id>3011</id><title_hr><![CDATA[Esencijalni metalni ioni u proteinima iz Helicobacter pylori i modelnim spojevima - struktura i funkcija/svojstvo]]></title_hr><title_en><![CDATA[Essential metal ions in Helicobacter pylori proteins and model complexes – structure and function/property]]></title_en><user_id>593</user_id><user_firstLast_name>Dubravka Matković-Čalogović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-4274</code><acronim><![CDATA[ProtModStruct]]></acronim><duration>01.06.2015 - 31.05.2019</duration><status>Završio</status><financ_value>128.741,12 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>1141, 358, 946, 4525, 4656, 12917, 11285, 3347, 1186, 3993, 3414, 4657, 19005, 20946, 19876, </team_members_id><team_members_names><![CDATA[Draginja Mrvoš-Sermek, Biserka Prugovečki, Ivica Đilović, Nenad Judaš, Ivana Biljan, Neven Smrečki-Lolić, Marijana Marković, Marina Tašner, Ivana Pulić, Giuseppe Zanotti, Janez Plavec, Dalibor Milić, Darko Vušak, Kristina Smokrović, Mario Kekez, ]]></team_members_names><keywords_hr><![CDATA[essential metals, model compounds, structural characterization, H. pylori proteins, chemical synthesis]]></keywords_hr><keywords_en><![CDATA[esencijalni metali, modelni spojevi, strukturna karakterizacija, proteini iz H. pylori, kemijska sinteza]]></keywords_en><summary_hr><![CDATA[U okviru istraživanja na ovom projektu želimo strukturno karakterizirati nekoliko proteina iz Helicobacter pylori (i odrediti njihovu funkciju) kao i modelne komplekse malih molekula sa esencijalnim metalnim ionima i biološki važnim ligandima (i odrediti njihova svojstva). Prioritetni će biti metali koji se nalaze u metaloproteinima iz H. Pylori.Svjetska zdravstvena organizacija proglasila je H. Pylori karcinogenom 1. klase te je važna meta istraživanja zbog svoje patogenosti. Proteini HypA i HypB su važni za pravilnu konstrukciju metalnog centra [Ni,Fe] hidrogenaze i urease. Proteini CrdA i CrdB potrebni su za održavanje koncentracije slobodnih iona bakra u citoplazmi ispod toksične razine. Namjeravamo klonirati, eksprimirati, pročistiti i karakterizirati kompleks HypA-HypB te proteine CrdA i CrdB biofizičkim i strukturnim metodama (termalna stabilnost, cirkularni dikroizam, određivanje konstante disocijacije bakrovog iona, rentgenska difrakcija, 3D NMR). Želimo odrediti funkciju metalošaperona u unutarstaničnoj regulaciji nikla (HypA-HypB) kao i mehanizam regulacije koncentracije bakra (CrdA, CrdB).Istraživati ćemo komplekse metala (bakra, nikla, željeza i drugih esencijalnih metala) s ciljem da odredimo preferirano koordinacijsko okruženje metala s aminokiselinama i derivatima aminokiselina (N-alkiliranih, amida, peptida, peptida bogatih metioninom i drugih) te dobijemo informaciju o specifičnosti aminokiselinskog ili peptidnog pokrajnjeg lanca prema različitim metalnim ionima. Komplekse ćemo sintetizirati te ih karakterizirati termičkim i spektroskopskim metodama i rentgenskom strukturnom analizom. Konstruirat ćemo konformacije bakrovih kompleksa s aminokiselinama te optimizirati njihovu geometriju pomoću kvantno-kemijskih proračuna da bismo istražili njihove moguće ravnotežne geometrije.]]></summary_hr><summary_en><![CDATA[Within this project we will structurally characterize several proteins from Helicobacter pylori (and reveal their functions) and small molecule model complexes of essential metal ions with biologically relevant ligands (and find their properties). The priority will be the essential metals involved in H. pylori metalloproteins.The World Health Organization has declared the H. pylori a Class 1 carcinogen and it is an important target for research due to its pathological relevance. H. pylori requires several accessory proteins such as HypA and HypB for the proper construction of the [Ni,Fe] hydrogenase and urease. The resistance determinants CrdA and CrdB are required for keeping the concentration of free copper ions in the cytoplasm below toxic levels. We plan to clone, express, purify and characterize the complex HypA-HypB and proteins CrdA and  CrdB by biophysical and structural methods (thermal stability assay, circular dichroism, determination of copper ion dissociation constant, X-ray diffraction, 3D NMR). We hope to determine how the metallochaperones exert their functions in intracellular nickel delivery (HypA-HypB) and the mechanism of copper level regulation (CrdA, CrdB).The aim of the study of the model complexes (with copper, nickel, iron, zinc and other essential metal ions) is to determine how these metals template their coordination environment by amino acids and their derivatives (N-alkylated, amides, peptides, methionine-rich peptides and others) and to obtain information on the specificity of amino acid or short peptide side chains toward different metal ions. The complexes will be synthesized and structurally characterized by thermal and spectroscopic analysis and X-ray crystal structure diffraction experiments.The conformations of the copper complexes with amino acids will be constructed and the geometry optimized to study their possible equilibrium geometries by quantum chemical calculations.]]></summary_en></project><project>
<id>3015</id><title_hr><![CDATA[Sveoubuhvatna procjena ponašanja i sudbine farmaceutski aktivnih tvari u okolišu: makrolidni antibiotici i opioidni analgetici]]></title_hr><title_en><![CDATA[Comprehensive assessment of the environmental behaviour and fate of pharmaceutically active contaminants: macrolide antibiotics and opioid analgesics ]]></title_en><user_id>3673</user_id><user_firstLast_name>Senka Terzić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-7031</code><acronim><![CDATA[COMPASS]]></acronim><duration>01.09.2015 - 28.02.2019</duration><status>Završio</status><financ_value>114.008,89 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, Biologija, </scie_field_hr><scie_field_en>Chemistry, Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>5324, 5719, 5179, 5188, 3923, 5158, 3674, 21293, </team_members_id><team_members_names><![CDATA[Ines Petrić, Marin Matošić, Ivona Krizman, Ivan Senta, Jovica Lončar, Iva Mikac, Marijan Ahel, Petra Kostanjevečki, ]]></team_members_names><keywords_hr><![CDATA[makrolidni antibiotici, opioidni analgetici, transformacijski proizvodi, transformacija, ozonizacija,  biološki efekti, otpadne vode ]]></keywords_hr><keywords_en><![CDATA[macrolide antimicrobials, opioid analgesics, transformation products, degradation, ozonization, biological effects, wastewaters]]></keywords_en><summary_hr><![CDATA[Većina studija farmaceutskih spojeva u okolišu usmjerena je na određivanje roditeljskih spojeva i uključuje samo jedan odjeljak okoliša. Takav pojednostavljeni pristup često podcjenjuje ekotoksikološku važnost neke farmaceutske skupine, bilo da se zanemaruje doprinos transformacijskih produkata (TP) ili tako da se previde neki kritični mehanizmi koji dovode do povećane opasnosti za okoliš i ljudsko zdravlje. Nasuprot tome, ovaj projekt ima za cilj ukazati na važnost sveobuhvatne evaluacije zagađivala voda na temelju istraživanja dviju skupina farmaceutskih spojeva, makrolidnih antibiotika (MA) i opioidnih analgetika (OA), pri čemu će biti uključeni njihovi glavni transformacijski produkti te će biti istražena uloga raspodjelnih procesa u procjeni izloženosti tim spojevima. Plan projekta predviđa razvoj visoko-specifičnih metoda za kvantitativno simultano određivanje ciljnih skupina spojeva i njihovih poznatih TP upotrebom tekućinske kromatografije povezane s tandemnom spektrometrijom masa(LC/MS/MS), dok će nepoznati TP biti identificirani upotrebom LC spregnute sa spektrometrijom masa visokog razlučivanja na temelju vremena leta (MS/TOF). Transformacijski procesi MA i OA bit će sustavno istraženi u kontroliranim laboratorijskim uvjetima, s posebnim naglaskom na biološku transformaciju i ozoniranje.  Biotransformacija će biti provedena s dobro karakteriziranim mješovitim mikrobnim kulturama izoliranim iz uzoraka s kronično zagađenih staništa. Istraživanje transformacijskih procesa obuhvatit će određivanje kinetike roditeljskih spojeva kao i identifikaciju transformacijskih produkata. Ekotoksikološki značaj istraživanih transformacijskih procesa bit će procijenjen kombinacijom postupaka baziranih na određivanju intenziteta nastajanja TP i promjene bioloških učinaka u nastalim transformacijskim smjesama. Projekt, na kraju, predviđa i verifikaciju relativne važnosti TP u realnim uvjetima, uključujući uređaje za pročišćavanje otpadnih voda i zagađene površinske vode.]]></summary_hr><summary_en><![CDATA[Most of the environmental studies of pharmaceuticals are focused mainly on the determination of parent compounds and encompass only one environmental compartment. Such simplified approach often underestimates the ecotoxicological relevance of a contaminant class, either by neglecting the contribution of its transformation products or by overlooking some critical mechanisms that may pose a threat to the environmental safety and human health. As opposed to that, this project aims at demonstrating the importance of the comprehensive assessment of aquatic contaminants, based on the study of two important groups of pharmaceuticals, macrolide antibiotics (MAs) and opioid analgesics (OAs), by including their main transformation products (TPs) and addressing the issue of physico-chemical partitioning in the exposure assessment. The project work plan envisages development of class-specific methods for the concurrent quantitative analysis of the target contaminants and their known TPs using liquid chromatography- tandem mass spectrometry (LC/MS/MS), while identification of unknown TPs will be performed using LC coupled to high-resolution mass spectrometry employing time-of-flight (TOF) mass analyzer. The transformation processes of selected contaminant classes will be systematically studied in laboratory-controlled conditions with a special emphasis on biotransformation and ozonation. The biotransformation experiments will be performed using well-characterised mixed microbial communities isolated from contaminated natural habitats. The transformation studies will encompass the determination of dissipation kinetics of the parent compounds as well as identification of TPs. Ecotoxicological importance of the transformation processes will be evaluated using a combination of exposure-driven and effect-driven approaches. Finally, the project envisages verification of the relative importance of TPs in real systems, including wastewater treatment plants and ambient surface waters.]]></summary_en></project><project>
<id>3016</id><title_hr><![CDATA[Fitohormoni u abiotskom stresu kupusnjača: mehanizam tolerancije i primjena]]></title_hr><title_en><![CDATA[Phytohormones in abiotic stress of  Brassica crops: mechanism of tolerance and application]]></title_en><user_id>791</user_id><user_firstLast_name>Branka Salopek Sondi</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-4359</code><acronim><![CDATA[PhytoBraCro]]></acronim><duration>01.09.2015 - 31.12.2019</duration><status>Završio</status><financ_value>121.166,37 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>12519, 998, 4217, 2689, 3827, 997, 3156, 3965, 2824, 5012, 3387, 3390, 17895, </team_members_id><team_members_names><![CDATA[Ondřej Novák, Hrvoje Lepeduš, NATAŠA BAUER, Dunja Šamec, Iva Pavlović, Selma Mlinarić, Jutta Ludwig-Müller, Ana Smolko, Jasenka Antunović, Snježana Mihaljević, Sandra Radić Brkanac, VALERIJA VUJČIĆ, Ida Linić, ]]></team_members_names><keywords_hr><![CDATA[kupusnjače, suša, solni stres, auksin, hormoni stresa]]></keywords_hr><keywords_en><![CDATA[Brassica crops, drought, salinity stress, auxin, stress hormons]]></keywords_en><summary_hr><![CDATA[Biljne vrste iz porodice Brassicaceae su široko rasprostranjene povrtne kulture. Abiotički stres poput suše i povećanog saliniteta tla su primarni uzroci gubitka u poljoprivrednoj proizvodnji. Fitohormoni su ključni za prilagodbu biljaka nepovoljnim uvjetima regulirajući procese kao što su fotosinteza, aktivnosti antioksidacijskih enzima, akumulacija sekundarnih metabolita, promjene u ekspresiji gena itd. Biljni hormoni auksini djeluju kao regulatori u većini odgovora biljaka na stres kroz složene interakcije s hormonima stresa: salicilnom (SA), abscizinskom (ABA), jasmonskom (JA) kiselinom i brazinosteroidima (BRA). Cilj ovog projekta je istražiti mehanizme odgovora odabranih biljaka iz porodice krstašica na stres uzrokovan sušom i povećanim salinitetom: kineski kupus (Brassica rapa), bijeli kupus (B. oleracea var. capitata) i raštika (B. oleracea var. acephala) kroz integrativni pristup koji podrazumjeva metode mjerenja fotosinteze, biokemijske metode dijagnostike stresa, metabolomiku (analize biljnih hormona i sekundarnih metabolita), molekularna funkcionalna te aplikativna istraživanja. Poseban naglasak će biti na ulozi fitohormona auksina i interakcijama s hormonima stresa (SA, ABA, JA, BRA) u odgovoru na sušu i povećani salinitet te potencijalnim mehanizmima tolerancije. Biljni hormoni biti će analizirani UHPLC-MS/MS metodom. Sekundarni metaboliti, polifenoli i glukozinolati biti će mjereni spektrofotometrijski i UHPLC-MS/MS metodama. Funkcionalna istraživanja će biti provedena na linijama uročnjaka (Arabidopsis thaliana) koje imaju mutacije u genima odgovornim za homeostazu auksina (gh3, ilr). Rezultati analiza bioaktivnih spojeva (hormona i sekundarnih metabolita) će biti korelirani s fiziološkim i biokemijskim podatcima (parametri fotosinteze, ROS, antioksidacijski enzimi, prolin, glutation, karbonili). Biljni hormoni stresa će biti ispitani kao potencijalni biostimulatori tolerancije na sušu i povećani salinitet aplikacijom na list i tretmanom korijena.]]></summary_hr><summary_en><![CDATA[Crops from the family of Brassicaceae are commercially widely spread vegetables. Abiotic stresses such as salinity and drought are the primary causes of crop loss worldwide. Phytohormones are crucial for the plant ability to adapt to abiotic stress by mediating a wide range of adaptive responses: photosynthesis modification, increased antioxidant activities, secondary metabolites accumulation, changes in gene expression. Phytohormone auxin regulates the majority of plant stress responses through interactions with stress hormones salicylic acid (SA), abscisic acid (ABA), jasmonic acid (JA), and brassinosteroids (BRA). The aim of this proposal is to investigate the abiotic stress responses of selected Brassica crops (Brassica rapa. ssp. pekinesis, Brassica oleracea var. capitata and Brassica oleracea var. acephala) to drought and salinity stress through integrative research approach comprising biophysical methods of photosynthesis measurements, biochemical methods of stress diagnostics, metabolomics (plant hormones and secondary metabolites) and molecular functional research. Particular focus will be placed to the role of auxin and its interactions with stress hormones (SA, ABA, JA and BRA) in stress responses and potential mechanisms of tolerance. Phytohormones auxin, SA, JA, ABA and BRA will be analyzed by UHPLC-MS/MS. Secondary metabolites, polyphenols and glucosinolates will be measured by spectrophotometry and UHPLC-MS/MS. In order to shed light on auxin homeostasis in abiotic stress, functional research will be performed by using Arabidopsis thaliana lines for genes of auxin reversible conjugation (GH3 and ILR). Results of hormonal analyses will be correlated with basic physiological and biochemical parameters (photosynthesis parameters, ROS level, antioxidant enzymes, proline, glutathione, protein carbonyl level). Finally, stress plant hormones will be investigate as potential biostimulator of abiotic stress tolerance by foliar spray and root treatment.]]></summary_en></project><project>
<id>3019</id><title_hr><![CDATA[Molekularni aspekti oksidativnih procesa u stanicama]]></title_hr><title_en><![CDATA[Molecular Aspects of Oxidative Processes in Cells]]></title_en><user_id>440</user_id><user_firstLast_name>Mario Vazdar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2014-09</proposal_call><code>UIP-2014-09-6090</code><acronim><![CDATA[MolOxStress]]></acronim><duration>01.09.2015 - 31.12.2018</duration><status>Završio</status><financ_value>74.258,41 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, Fizika, Biologija, </scie_field_hr><scie_field_en>Chemistry, Physics, Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>243, 373, 5002, 21289, 3618, </team_members_id><team_members_names><![CDATA[Davor Margetić, Katarina Vazdar, Danijela Vojta, Sanja Škulj, Zlatko Brkljača, ]]></team_members_names><keywords_hr><![CDATA[oksidativni stres, reaktivni aldehidi, membranski proteini, organska sinteza, molekulska dinamika, kvantnokemijski računi]]></keywords_hr><keywords_en><![CDATA[oxidative stress, reactive aldehydes, membrane proteins, organic synthesis, molecular dynamics, quantum chemical calculations]]></keywords_en><summary_hr><![CDATA[Cilj predloženog projekta je otkrivanje molekulskih detalja procesa vezanih za prijenos protona i oksidativni stres u mitohindrijima, organelima lociranim u stanicama koji služe za pretvorbu kisika i vanjskih izvora energije u adenozin trifosfat (ATP), u procesu oksidativne fosforilacije. Tijekom ovog procesa, osjetljiva energetska ravnoteža se održava pumpanjem protona izvan unutarnje mitohindrijske membrane uz pomoć lanca elektron-transport proteina te njihovog vraćanja unutra u procesu sinteze ATP-a pomoću ATP sintaze. Ova ravnoteža nije uvijek optimalna i posebna klasa proteina smještenih unutar unutrašnje mitohondrijske membrane, tzv. razvezujući proteini (&#39;&#39;uncoupling proteins&#39;&#39;), služe za kontrolu prijenosa protona kroz membranu.Posebna pažnja posvetit će se studiju reaktivnosti različitih reaktivnih aldehida koji se stvaraju tijekom oksidativnog stresa unutar fosfolipidnog dvosloja, prema razvezujućim proteinima. Ove štetne reakcije povećavaju aktivnost razvezujućih proteina koji dovodi i do povećanog protoka protona kroz unutrašnju mitohondrijsku membranu koja time mijenja energetsku ravnotežu unutar stanice što dovodi do raznih opasnih bolesti, poput raka, dijabetesa tipa 2 i pretilosti.Projekt će koristiti najnovije računske pristupe uz kombinaciju kvantnokemijskih računa i simulacija molekulske dinamike. Nadalje, teorijski proračuni će se nadopuniti modelnim eksperimentima gdje će se ispitati sintetizirani reaktivni aldehidi sa svrhom daljnjeg razumijevanja reaktvnosti, kao i dodatne provjere računskih rezultata.Ovo istraživanje će doprinijeti očuvanju zdravlja pružajući zajednici bolje razumijevanje osnovnih principa i mehanizama pomoću kojih opasni aldehidi reagiraju s razvezujućim proteinima. Predložit će se nove ideje s ciljem boljeg razumijevanja funkcije razvezujućih proteina, razvijanja lijekova za unaprijeđenje zdravlja te umanjivanju efekata oksidativnih procesa.]]></summary_hr><summary_en><![CDATA[The proposed project aims to unravel the molecular details of the processes connected with proton transfer and oxidative stress in mitochondria, organelles located in cells which convert oxygen and external energy supply into adenosine triphosphate (ATP) in the process of oxidative phosphorylation. During this process, a delicate energy balance is maintained between pumping of protons outside the inner mitochondrial membrane by the electron-transport chain proteins and transferring them back inside in the process of ATP synthesis by the ATP synthase. This balance is not always optimal and a special class of membrane proteins located inside inner mitochondrial membranes, called uncoupling proteins, serves as a control of the proton transfer rate through the membrane. Particular attention will be paid to the study of the reactivity of various reactive aldehydes generated during oxidative stress within phospholipid bilayers, towards uncoupling proteins. These deleterious reactions enhance the activity of uncoupling proteins resulting in the increased proton leak through inner mitochondrial membrane which in turn modifies energy balance inside the cell leading to various harmful diseases, such as cancer, type 2 diabetes and obesity. The project application uses the &#39;&#39;state of the art&#39;&#39; computational approach by combining quantum chemical calculations and molecular dynamics simulations. Also, the theoretical work is expanded with the experimental work where model compounds will be synthesized and used in model reaction systems to further understand and cross-check the simulation results. The research will endorse health by providing the community better understanding of the underlying principles and mechanisms by which deleterious aldehydes react with uncoupling proteins. The novel ideas will be proposed in order to better understand the function of uncoupling proteins, to develop drugs for improving health and to minimize effects due to oxidation processes.]]></summary_en></project><project>
<id>3021</id><title_hr><![CDATA[SenseHive: Dinamički modeli za postepenu izgradnju leksičko-semantičkih resursa potpomognuti radom mnoštva]]></title_hr><title_en><![CDATA[SenseHive: Dynamic Crowdsourcing Models for Incremental Construction of Lexico-Semantic Resources]]></title_en><user_id>6211</user_id><user_firstLast_name>Jan Šnajder</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2014-09</proposal_call><code>UIP-2014-09-7312</code><acronim><![CDATA[SenseHive]]></acronim><duration>01.10.2015 - 30.11.2018</duration><status>Završio</status><financ_value>94.233,19 eur</financ_value><scie_area_hr>Tehničke znanosti, Humanističke znanosti, </scie_area_hr><scie_area_en>Technological sciences, Humanities, </scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>6330, 6463, 6670, 1533, 7143, 7187, 7390, 7141, 13422, 18931, 22839, </team_members_id><team_members_names><![CDATA[Sebastian Pado, Darja Fišer, Tomislav Stojanov, Željko Agić, Nikola Ljubešić, Bojana Dalbelo Bašić, Mladen Karan, Goran Glavaš, Luka Skukan, Domagoj Alagić, Abbas  Akkasi, ]]></team_members_names><keywords_hr><![CDATA[Natural language processing, language technologies, lexical semantics, semantic resources, word sense disambiguation, Croatian language]]></keywords_hr><keywords_en><![CDATA[Obrada prirodnog jezika, jezične tehnologije, leksička semantika, semantički resursi, razrješavanje višeznačnosti, hrvatski jezik]]></keywords_en><summary_hr><![CDATA[Leksičko-semantički resursi igraju bitnu ulogu u obradi prirodnoga jezika i srodnih primjena poput pretraživanja informacija. Nažalost, njihova je  izgradnja izuzetno skupa te je rijetko vođena praktičnim potrebama, što kod jezika sa slabije razvijenim resursima predstavlja naročit problem. Moguće rješenje jest izgradnja leksičko-semantičkih resursa potpomognuta radom mnoštva (engl. crowdsourcing). Premda se rad mnoštva pokazao izvedivim i znatno povoljnijim pristupom, još uvijek ne postoji cjelovita metodologija koja bi omogućila postepenu izgradnju vrlo velikih leksičko-semantičkih resursa. Cilj ovoga projekta jest upotpuniti ovu prazninu i istražiti računalne modele i metode za postepenu i učinkovitu izgradnju leksičko-semantičkih resursa potpomognutu radom mnoštva. Istraživanje će objediniti modele za dinamičan rad mnoštva, modele semantike temeljene na korpusu (distribucijske modele i tematske modele) te aktivno strojno učenje, te polučiti cjelovit i jezično neovisan radni okvir, tzv. SenseHive. SenseHive objedinjuje prilagodiv prikaz značenja i leksičko-semantičkih veza riječi temeljen na grafovima (SenseGraph) i postupke za njegovu postepenu izgradnju. Značenja riječi dinamički se razdjeljuju i stapaju na temelju analize ljudskih ocjena dobivenih nad podatcima ekstrahiranima iz korpusa. U prvoj fazi projekta izgradit ćemo prototip i upotrijebiti ga za ciljane eksperimente na podatcima na hrvatskom, slovenskom i engleskom jeziku s ciljem odgovaranja na relevantna istraživačka pitanja. Kao dokaz koncepta, u drugoj ćemo fazi primijeniti SenseHive za izgradnju leksičko-semantičkog resursa za hrvatski jezik umjerene veličine, proširivanjem i obogaćivanjem postojećih leksičko-semantičkih resursa. Predloženo će istraživanje unaprijediti stanje znanosti u području računalne semantike i poluatomatske izgradnje jezičnih resursa te rezultirati konkretnim leksičko-semantičkim resursom za hrvatski jezik od velike praktične vrijednosti.]]></summary_hr><summary_en><![CDATA[Lexico-semantic resources play an essential role in natural language processing and related applications such as information retrieval. Unfortunately, their construction is extremely costly and rarely guided by practical considerations, posing a problem especially for less-resourced languages. One possible solution is to rely on crowdsourcing of lexico-semantic resources. Although crowdsourcing has proven to be a viable option for reducing the overall costs, there still does not exists a comprehensive crowdsourcing methodology for incremental construction of large-scale lexico-semantic resources. This projects aims to fill this gap by investigating the computational models and methods for incremental and cost-efficient crowdsourcing of lexico-semantic resources. The research will combine dynamic crowdsourcing, corpus-based models of semantics (distributional semantics and topic models), and active machine learning methods into a comprehensible and language-independent crowdsourcing framework, the SenseHive. The SenseHive consists of a flexible, graph-based representation of senses and lexico-semantic relations (SenseGraph), coupled with an incremental construction methodology. In SenseGraph, senses are dynamically split up and merged based on the analysis of human judgments on corpus-extracted data. In the first phase, we will implement a prototype of the SenseHive framework and use it for focused evaluation experiments on Croatian, Slovene, and English data to answer the relevant research questions. As a proof of concept, in the second phase we will use SenseHive to construct a medium-sized lexico-semantic resource for Croatian by enlarging and enriching existing lexico-semantic resources. The proposed research will advance the state of the art in computational lexical semantics and semi-automated construction of linguistic resources, and yield a lexico-semantic resource for Croatian of great practical value.]]></summary_en></project><project>
<id>3023</id><title_hr><![CDATA[Struktura i dinamika egzotičnih femto-sustava]]></title_hr><title_en><![CDATA[Structure and Dynamics of Exotic Femtosystems]]></title_en><user_id>11296</user_id><user_firstLast_name>Nils Paar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-9159</code><acronim><![CDATA[STRUDEF]]></acronim><duration>01.06.2015 - 31.05.2019</duration><status>Završio</status><financ_value>132.652,60 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>780, 12571, 18998, 25236, </team_members_id><team_members_names><![CDATA[Tamara Nikšić, Deni Vale, Nato Popara, Tomohiro Oishi, ]]></team_members_names><keywords_hr><![CDATA[egzotične jezgre, energijski  funkcional gustoće, kolektivno gibanje, fisija, beta raspad, gibanje velikih amplituda]]></keywords_hr><keywords_en><![CDATA[exotic nuclei, energy density functional, nuclear collective motion, fission, beta decay, large amplitude motion]]></keywords_en><summary_hr><![CDATA[Osnovni cilj ovog projekta je razviti i primijeniti novi teorijski pristup, zasnovan na relativističkom nuklearnom energijskom funkcionalu gustoće (RNEDF) koji  omogućuje mikroskopski opis strukture i dinamike kvantnih sustava na femtometarskoj skali, te omogućuje precizan opis egzotičnih femto-sustava daleko od doline stabilnosti koji još nisu dostupni u eksperimentu. Radi se o jezgrama čija struktura i dinamika pokazuju egzotična svojstva, npr. veličinu i oblik vrlo različite od najbližih stabilnih jezgara, ili egzotične modove kolektivnog pubuđenja i raspada. Istraživački projekt uključuje razvoj teorijskog formalizma i pripadajućih modela na temelju RNEDF-a radi ostvarenja sljedećih ciljeva: (i) razviti pouzdanije funkcionale s unaprijeđenom efektivnom masom blizu Fermi površine i poboljšanim spin-orbit međudjelovanjem u izovektorskom kanalu, (ii) omogućiti kvantitativni opis statističke neodređenosti i korelacija između nuklearnih svojstava pomoću analize kovarijanci, (iii) opisati pobuđenja malih amplituda pomoću metode konačnih amplituda i vezanjima sa složenim konfiguracijama, (iv) nadograditi metodu generatorskih koordinata za gibanje velikih amplituda, (v) istražiti fenomene koegzistencije oblika i prijelaza između različitih oblika jezgara, (vi) proučiti strukturu i stabilnost superteških jezgara i proces fisije (vii) istražiti astrofizički značajne nuklearne procese koji uključuju slabu interakciju. Predviđen je razvoj naprednih teorijskih metoda za rješavanje izazova koje predstavljaju sadašnji i budući ubrzivači snopova nestabilnih iona, odnosno razumijevanje rijetkih jezgara daleko od stabilnosti koje igraju značajnu ulogu u sintezi svih stabilnih kemijskih elemenata koji danas postoje na Zemlji. Ključni pristup za ostvarenje znanstvenih ciljeva i povećanje prediktivne snage za opis egzotičnih femto-sustava je razvoj i primjena učinkovitih računalnih alata i metoda naprednog računarstva i njihova primjena na distribuiranim računalnim sustavima.]]></summary_hr><summary_en><![CDATA[The goal of this project is to develop and apply a novel theoretical framework, based on Relativistic Nuclear Energy Density Functional (RNEDF) that enables microscopic modeling of the structure and dynamics of quantum systems at the femtometer scale, and provides accurate predictions for exotic femtosystems far from stability that are not yet accessible in experiment. These nuclei have exotic or unusual structural and dynamical properties such as, for instance, sizes and shapes very different from their nearest stable nuclei, or exotic modes of collective excitation and decay by particle emission. The project research includes development of the framework based on the RNEDF with specific aims to (i) develop a more reliable functional with enhanced effective mass near the Fermi surface and improved spin-orbit interaction in the isovector channel, (ii) provide quantitative description of statistical uncertainties and correlations of nuclear properties using covariance analysis, (iii) to describe low-amplitude motion using finite amplitude method and couplings with complex configurations, (iv) upgrade the generator-coordinate method framework for large amplitude motion , (v) explore phenomena of shape coexistence and shape transitions, (vi) study the structure and stability of superheavy nuclei and fission process, (vii) explore astrophysically relevant nuclear processes including weak interaction. This will require the development of advanced theoretical methods to resolve the challenge posed by the current and future large-scale radioactive ion beam facilities, namely the understanding of rare nuclei far from stability that are precursors in the synthesis of all stable nuclear species on Earth. A key ingredient in achieving the theoretical goal of increased predictive power for exotic femtosystems is development and application of efficient computational tools and methods of scientific computing using distributed computer systems.]]></summary_en></project><project>
<id>3024</id><title_hr><![CDATA[Procesna i poslovna inteligencija za poslovnu izvrsnost ]]></title_hr><title_en><![CDATA[Process and Business Intelligence for Business Performance ]]></title_en><user_id>1246</user_id><user_firstLast_name>Vesna Bosilj Vukšić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-3729</code><acronim><![CDATA[PROSPER]]></acronim><duration>01.09.2015 - 31.08.2019</duration><status>Završio</status><financ_value>29.995,35 eur</financ_value><scie_area_hr>Društvene znanosti, Tehničke znanosti, </scie_area_hr><scie_area_en>Social sciences, Technological sciences, </scie_area_en><scie_field_hr>Informacijske znanosti, Računarstvo, Ekonomija, </scie_field_hr><scie_field_en>Information sciences, Computer sciences, Economy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Ekonomski fakultet u Zagrebu]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Economics and Business]]></institution_en><team_members_id>1372, 3650, 1313, 3417, 3436, 3630, 1272, 3588, 3695, 3766, 3106, 4411, 2520, 22659, </team_members_id><team_members_names><![CDATA[Mirjana Pejić Bach, Božidar Jaković, Jovana Zoroja, Ljubica Milanović Glavan, Mirta Baranović, Ljiljana Brkić, Katarina Tomičić-Pupek, Jurij Jaklič, Mojca Indihar Štemberger, Aleš Popovič, Amer Celjo, Jan Mendling, Dalia Suša, Ana-Marija Stjepić, ]]></team_members_names><keywords_hr><![CDATA[procesna inteligencija, poslovna inteligencija, upravljanje poslovnim procesima, mjerenje i upravljanje performansama, rudarenje podataka, softver]]></keywords_hr><keywords_en><![CDATA[process intelligence, business intelligence, business process management, performance measurement and management, data mining, software]]></keywords_en><summary_hr><![CDATA[Svrha projekta PROSPER je istražiti primjenu procesne (PI) i poslovne inteligencije (BI) u poduzećima i njihov utjecaj na uspješnost poslovanja, s posebnim fokusom na korištenje modernih tehnologija (kao što su sustavi za upravljanje poslovnim procesima, rudarenje podataka, simulacijski softver) pri implementaciji ovih koncepata. Primijenit će se odgovarajući istraživački pristup. Koristiti će se statističke metode (kao što su modeli strukturnih jednadžbi - SEM) i metode kvalitativnog istraživanja (na primjer kvalitativno istraživanje kulturalnih razlika primjene procesne i poslovne inteligencije u u Hrvatskoj, Sloveniji, Austriji i Bosni i Hercegovini). Projekt je multidisciplinaran i više-razinski, a njegovi su ciljevi hijerarhijski strukturirani.Na najvišoj razini (L1) istražit će se primjena i zrelost procesne i poslovne inteligencije u  zemljama iz kojih dolaze suradnici na projektu. Provest će se empirijsko istraživanje, dobiveni rezultati analizirati će se kvantitativnim metodama (regresijska i faktorska analiza). Na drugoj razini (L2) istražit će se kritični faktori uspješnosti primjene koncepata procesne i poslovne inteligencije. U tu svrhu će se koristiti kvalitativne (studije slučaja, polu-strukturirani intervjui)  i kvantitativne metode (modeli strukturnih jednadžbi).  Rezultati istraživanja koristiti će se za razvoj modela za mjerenje procesnih performansi. Na trećoj razini (L3) testirati će se primjenjivost rezultata istraživanja iz prethodnih razina (L1 i L2), a u tu svrhu će se provesti kvalitativno istraživanje u poduzećima. Kroz studije slučaja testirati će primjena procesne i poslovne inteligencije i njihov utjecaj na uspješnost poslovanja.  Razviti će se modeli iz područja poslovne inteligencije za neke specifične poslovne slučajeve i djelatnosti. Primjena ovih modela omogućiti će uspješnije poslovanje. ]]></summary_hr><summary_en><![CDATA[The aim of the PROSPER project is to examine the adoption of the process intelligence (PI) and business intelligence (BI) in organizations, as well as to foresee their impact on business performance using cutting-edge technologies (e.g. business process management systems, data mining, simulation software) and research approach (e.g. cross-cultural research, structural equation modelling) with the assistance of multi-country (Croatia, Slovenia, Austria, Bosnia and Herzegovina) and interdisciplinary team of university researchers. The project is multidisciplinary and multi-levelled due to the hierarchical structure of its objectives.At the highest level (L1), the adoption and maturity of PI and BI will be explored in organizations in Croatia, Slovenia, Bosnia and Herzegovina and Austria. A quantitative empirical research results will be analysed using regression and factor analysis. At the middle level (L2), the impact of critical factors (e.g. organizational culture and structure) on PI and BI adoption will be analyzed. L2 research results will be explored using qualitative (e.g. case study, semi-structured interviews) and quantitative methods (e.g. structural equation modelling), the goal being development of the process performance measurement model. At the third level (L3), the practical applicability of the L1 and L2 research results will be tested and evaluated using specific business cases in PI and BI adoption for business performance. Models will be developed for the usage of BI in some specific business cases and industries, with the goal of increasing business performance.]]></summary_en></project><project>
<id>3027</id><title_hr><![CDATA[Višekomponentne reakcije u sintezi peptidnih mimetika]]></title_hr><title_en><![CDATA[The assembly of peptidomimetics by multicomponent reactions]]></title_en><user_id>66</user_id><user_firstLast_name>IVANKA JERIĆ</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-3102</code><acronim><![CDATA[MIMICRy]]></acronim><duration>01.09.2015 - 31.08.2019</duration><status>Završio</status><financ_value>125.821,22 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>558, 715, 717, 12506, 12613, 12635, 373, 21264, 24292, 25282, </team_members_id><team_members_names><![CDATA[Matija Gredičak, Lidija Brkljačić, Josipa Suć, Kristina Vlahoviček-Kahlina, Lidija Varga-Defterdarović, Andreja  Jakas, Katarina Vazdar, Mladena Glavaš, Ivana Kovačić, Mateja Matišić, ]]></team_members_names><keywords_hr><![CDATA[peptidomimetici, višekomponentne reakcije, makrociklički spojevi, neprirodne aminokiseline, ugljikohidrati, endiinski spojevi]]></keywords_hr><keywords_en><![CDATA[peptidomimetics, multicomponent reactions, macrocycles, non-natural amino acids, carbohydrates, enediyne compounds]]></keywords_en><summary_hr><![CDATA[Probir biblioteka malih molekula je najčešće korišten pristup u otkriću novih lijekova u posljednih dvadeset godina. Međutim, glavni nedostatak biblioteka je mala raznovrsnost bioloških i kemijskih svojstva spojeva koje sadrže, tj. biblioteke pokrivaju vrlo mali «kemijski prostor». U posljednjih 15 godina, svega 15 % novih kemijskih spojeva zapravo pripadaju novim klasama spojeva. To predstavlja glavnu zapreku razvoju novih vodećih spojeva potrebnih za istraživanje novih bioloških meta. Cilj ovog projekta je proširiti kemijski prostor novim spojevima koji imaju slične karakteristike kao i prirodni spojevi, korištenjem višekomponentnih reakcija. To ćemo postići: (a) razvojem novih gradivnih jedinica temeljenih na neprirodnim aminokiselinama, ugljikohidratima i endiinskim spojevima, (b) provođenjem Passerinijeve i Ugijeve reakcije za dobivanje raznovrsnih linearnih i cikličkih produkata i (c) proučavanjem stereokemije višekomponentnih reakcija.  	Rezultati projekta i znanje o metodologiji, stereokemiji i svojstvima novih spojeva značajni su za istraživanja u više područja: medicinska kemija (nove strukture za obogaćivanje biblioteka spojeva), razvoj katalizatora (posebno makrociklički spojevi s endiinskom jedinicoma) i biomedicinska istraživanja (spojevi s ugljikohidratnim strukturnim elementom mogu se koristiti kao biološke probe). Projekt je usklađen s ciljevima Hrvatske zaklade za znanost: razvoj konkurentnog istraživačkog okruženja i stvaranje novih znanja za jačanje hrvatskog gospodarstva. Rezultati projekta će biti temelj za stvaranje bibliteka sa strukturno različitim malim molekulama i makrocikličkim spojevima, kao odgovor na potrebe farmaceutske industrije: identifikacija još nepoznatih bioloških ciljeva i razvoj novih vodećih spojeva. Stoga projekt doprinosi i jednom od ključnih ciljeva u Europskoj uniji: poboljšanju zdravlja građana EU-a za povećanje bogatstva i dobrobiti ljudi. ]]></summary_hr><summary_en><![CDATA[Screening of small-molecule libraries has been the most commonly used tool in drug discovery over the past two decades. However, currently used libraries lack diversity in terms of biological and chemical properties, i.e. “chemical space” covered is infinitely small. In the past 15 years, only 15 % of the emerging novel chemical entities have been novel classes of compounds. This limitation significantly hampers development of novel lead compounds needed to tackle new generations of biological targets. The project goal is to expand the chemical space of natural product-like compounds by using multicomponent reactions. This will be achieved by: (a) developing novel non-natural amino acid-, carbohydrate- and enediyne-based building blocks; (b) performing Passerini and Ugi multicomponent reactions to obtain structurally diverse linear and macrocyclic compounds and (c) studying the stereochemistry of multicomponent reactions. Project results, and the knowledge about methodologies, stereochemistry and properties of novel compounds, are highly relevant for the following fields: medicinal chemistry - novel structures to fill the libraries; catalyst development – particularly enediyne-based macrocycles; and biomedical studies – carbohydrate-based compounds can be used as biological probes. Project is aligned with the goals of the Croatian Science Foundation: development of competitive research environment, and creation of new knowledge for the strengthening the Croatian economy. Project results will be the base for the generation of libraries with structurally diverse peptide-like small molecules and macrocyclic compounds, as an answer to the pharmaceutical industry needs: identification of yet undisclosed biological targets and the development of novel lead compounds. Therefore, project contributes to one the key objectives in the European Union: improving the health of EU citizens for generation of wealth and public wellbeing. ]]></summary_en></project><project>
<id>3030</id><title_hr><![CDATA[Internet stvari - okvir interoperabilnosti]]></title_hr><title_en><![CDATA[Internet of Things – Interoperability Framework ]]></title_en><user_id>12678</user_id><user_firstLast_name>Neven Vrček</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-3877</code><acronim><![CDATA[IoTIF]]></acronim><duration>01.06.2015 - 31.05.2019</duration><status>Završio</status><financ_value>78.322,90 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Informacijske znanosti, </scie_field_hr><scie_field_en>Information sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet organizacije i informatike]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Organization and Informatics]]></institution_en><team_members_id>12786, 5699, 12796, 202, 12805, 12793, 13514, 13611, 13612, 2508, </team_members_id><team_members_names><![CDATA[Sandro Gerić, Renata Mekovec, Darko Andročec, Boris Tomaš, Igor Pihir, Tonimir Kišasondi, Mate Boban, Dragutin Kermek, Matija Novak, Igor Tomičić, ]]></team_members_names><keywords_hr><![CDATA[internet stvari, energetska učinkovitost, interoperabilnost, automatsko konfigurabilne arhitekture, pitanja sigurnosti i privatnost]]></keywords_hr><keywords_en><![CDATA[Internet of Things, energy efficiency, large scale interoperability, automated architecture reconfiguration, security and privacy issues]]></keywords_en><summary_hr><![CDATA[Internet stvari je „dinamična globalna mrežna infrastruktura koja ima mogućnost automatske konfiguracije i bazirana je na standardnim interoperabilnim komunikacijskim protokolima gdje fizičke i virtualne stvari posjeduju identitete, fizičke atribute i virtualne osobnosti, koriste inteligentna sučelja, te su integrirani u informacijsku mrežu“ (Vermesan, 2014). Općenito, Internet stvari (IoT) se opisuje kao globalna mreža međusobno povezanih entiteta poput ljudi, računala, knjiga, vozila koji mogu ostvariti otvorenu komunikaciju s bilo kojim drugim entitetom i mjestom na bilo koji način (Roman, Zhou i Lopez, 2013). IoT mreža je iznimno heterogena, te kako bi se iskoristili njezini potencijali potrebno je ostvariti visoku razinu interoperabilnosti između uređaja u IoT mreži. Istraživanja interoperabilnosti u IoT okruženju su još u početnim fazama. U okviru projekta usmjerit ćemo se na interoperabilnost na razini usluga, te upotrebom semantičkog jezika i AI algoritama pokušati riješiti probleme konfigurianja i interoperabilnosti u IoT okruženju. Ideja je predstaviti IoT uređaje kao usluge (servise) te ih opisati semantičkim jezikom (SA-WSDL). Pri tome će se razviti OWL ontologija za opis elemenata IoT okruženja. Uključeni IoT uređaji će biti opisani, njihove funkcije i operacije također, što će omogućiti razvijenom algoritmu umjetne inteligencije da kombinira i dinamički u IoT okruženje uključuje i povezuje one uređaje koji doprinose rješavanju zadanog problema. Uz to će se ostvariti integracija IoT uređaja sa cloud platformom, čiji kapaciteti se mogu iskoristiti kao podrška i dodatna funkcionalnost IoT okruženju.]]></summary_hr><summary_en><![CDATA[Internet of Things (IoT) is “a dynamic global network infrastructure with self configuring capabilities based on standard and interoperable communication protocols where physical and virtual things  have identities, physical attributes, and virtual personalities; use intelligent interfaces; and are seamlessly integrated into the information network”. It is highly-heterogeneous, so to unleash its full value we must to achieve interoperability among various things. Research on the interoperability of IoT is in the initial stage. We will focus on service-level interoperability and we will use lightweight semantic language and AI planning methods to resolve found problems of heterogeneous things abstracted in form of semantic web services. Our idea is to represent things as services and semantically annotate them by using lightweight semantic language such as SA-WSDL. OWL Ontology for describing the things and their most important operations will be developed. Things as services will be annotated using the developed ontology, together with their main operations and operations’ input and output. AI planning problem and domain will be formulated to enable composition of various things as services. Then an AI tool together with web interface will be developed to enable users to achieve more complex tasks composing various things and their capabilities. We will investigate how we can integrate our approach with existing cloud computing services, i.e. we will develop a framework for integration of clouds and Internet of Things. Cloud services can enrich things as service with storage, application and resource capabilities. Therefore, cloud services will be semantically annotated using similar approach as semantically annotated smart things. This will enable us to create compositions of different things as services and cloud services to support more complex interoperability scenarios by using common ontology and AI planning method. ]]></summary_en></project><project>
<id>3031</id><title_hr><![CDATA[Novi enološki postupci kao alternativa sumporovom dioksidu u proizvodnji visokokvalitetnih vina]]></title_hr><title_en><![CDATA[New enological tools for the reduction of sulfur dioxide and production of high-quality wine]]></title_en><user_id>6224</user_id><user_firstLast_name>Karin Kovačević Ganić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-3796</code><acronim><![CDATA[LOWSULF-HQWINE]]></acronim><duration>01.09.2015 - 31.08.2019</duration><status>Završio</status><financ_value>124.646,63 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Prehrambena tehnologija, </scie_field_hr><scie_field_en>Food technology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Food Technology and Biotechnology]]></institution_en><team_members_id>13101, 13272, 13352, 222, 13282, 2653, 21313, </team_members_id><team_members_names><![CDATA[Ksenija Marković, Natka Ćurko, Tomislav Bosiljkov, Marina Đapić, Leo Gracin, Stela Križanović, Katarina Lukić, ]]></team_members_names><keywords_hr><![CDATA[Vino, SO2, antimikrobno djelovanje, kvaliteta vina, ultrazvuk visokog intenziteta (HPU), visoki hidrostatski tlak (HHP), hladna plazma (NTP)]]></keywords_hr><keywords_en><![CDATA[wine, SO2, antimicrobial activity, wine quality, high power ultrasound (HPU), high hydrostatic pressure (HHP) and non-thermal plasma (NTP)]]></keywords_en><summary_hr><![CDATA[Suvremeni zahtjevi za povećanjem sigurnosti i kvalitete vina utjecali su na preporuke o smanjenju, ali i na nove zakonske restrikcije u upotrebi sumporovog dioksida. Naime, zbog svojih antimikrobnih i antioksidacijskih karakteristika, sumporov dioksid jedan je od najučinkovitijih aditiva u proizvodnji vina. Međutim, uslijed potencijalnih pseudo-alergijskih reakcija koje kod osjetljivih pojedinaca dovode do zdravstvenih problema, korištenje sumporovog dioksida danas je pod razmatranjem. Stoga su i znanstvena istraživanja u posljednjem desetljeću intenzivno usmjerena na pronalaženje alternativa sličnih antiseptičkih i antioksidacijskih svojstava, kojima bi se zamijenila/smanjila upotreba sulfita u proizvodnji vina; što i danas predstavlja jedan od najznačajnijih enoloških izazova. U posljednje vrijeme, tehnologije kao ultrazvuk visokog intenziteta (HPU), visoki hidrostatski tlak (HHP) te hladna plazma (NTP) otvorile su nove mogućnosti u kontroli mikrobiološke kvalitete hrane te su stoga našle sve veću primjenu u prehrambenoj industriji. Međutim, primjena ovih novih, netermalnih postupaka u proizvodnji vina i njihov utjecaj na mikrobiološku stabilnost vina do sada nije istražen. Cilj projekta je istražiti mogućnosti primjene HPU, HHP i NTP sa svrhom smanjenja upotrebe sumporovog dioksida u proizvodnji visokokvalitetnih crnih, bijelih i desertnih vina. Ispitat će se utjecaj ovih netermalnih postupaka na cjelokupnu kvalitetu vina, u prvom redu na sastav polifenola, arome te senzorske karakteristike vina. Također, istražit će se mogućnosti ovih postupaka u kontroli mikrobiološke stabilnost vina. Nadalje, ispitat će se i sinergijski učinak navedenih postupaka te dodatka antioksidansa (niži udio sumporovog dioksida i glutation) tijekom dozrijevanja vina u bocama. Rezultati ovog projekta pokazat će kako primjenom novih netermalnih tehnologija samostalno ili u kombinaciji s antioksidansima proizvesti vina poboljšane kvalitete s nižim udjelom sumporovog dioksida.]]></summary_hr><summary_en><![CDATA[Modern increasing requirements for wine safety and quality led to very restrictive legislation regarding sulfur dioxide addition recommending limitations or even complete suppressing. In fact, sulfur dioxide is one of the most efficient additives used in winemaking due to its antimicrobial and antioxidant properties. However, as a result of potential pseudo-allergenic health problems in sensitive individuals use of sulfur dioxide has recently come under the review. Hence, in recent decades, alternatives to reducing/replacing sulfites in winemaking have been extensively studied. However, finding promising substitutes with similar antiseptic and antioxidant characteristics still remains major challenge. Recently, emerging technologies such as high power ultrasound (HPU), high hydrostatic pressure (HHP) and non-thermal plasma (NTP) have entered the field of food science and technology offering, as novel tools, new opportunities for managing food microbiology. Their opportunities in wine microbiology have not been examined. The aim of this project is to study the potential usage of HPU, HHP and NTP in production of high quality red, white and dessert wine as sulfur dioxide reducing strategies, and furthermore to optimize their application. Impact on overall wine quality, particularly chemical and sensory characteristic will be studied. Possibilities of these new technologies in controlling microbiological stability of wine will be investigated. In addition, synergistic practices of these physical technologies with antioxidants (lower content of sulfur dioxide and glutathione) during long period of aging in the bottles will be studied. The results of this project are expected to provide information how application of new physical technologies on its own or in combination with antioxidant addition can lead to wines with lower levels of sulfur dioxide and improved quality.]]></summary_en></project><project>
<id>3041</id><title_hr><![CDATA[Pogrebni običaji starijeg željeznog doba u južnoj Panoniji - raskrižja identiteta]]></title_hr><title_en><![CDATA[Burial Customs of the Early Iron Age in Southern Pannonia - Crossroads of Identity]]></title_en><user_id>3432</user_id><user_firstLast_name>Hrvoje Potrebica</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-1234</code><acronim><![CDATA[BC-CrossId]]></acronim><duration>01.06.2015 - 31.05.2019</duration><status>Završio</status><financ_value>79.633,69 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Arheologija, </scie_field_hr><scie_field_en>Archeology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>12745, 12736, 12812, 11263, 12982, 12742, 25275, </team_members_id><team_members_names><![CDATA[Petra Stipančić, Janja Mavrović Mokos, Borut Križ, Branko Mušič, Renata Šoštarić, Andrijana Pravidur, Julia Katarina Fileš Kramberger, ]]></team_members_names><keywords_hr><![CDATA[starije željezno doba, pogrebni običaji, identitet, halštatska kultura, pogrebne gomile, elite, kneževski grobovi, Alpe, Panonija]]></keywords_hr><keywords_en><![CDATA[Early Iron Age, burial customs, identity, Hallstatt Culture, burial mounds, elites, princely burials, Alps, Pannonia]]></keywords_en><summary_hr><![CDATA[Cilj ovog projekta jest utvrditi način na koji željeznodobne zajednice izražavaju svoj identitet kroz pogrebni ritual. Pri istraživanju bi se u najvećoj mjeri primjenjivao kontekstualni pristup: materijalna kultura se neće promatrati isključivo kao tipološka kategorija nego će biti povezana s kontekstom pogrebnog inventara i rituala. Namjera nam je pokazati da je mobilnost bila daleko intenzivnija i veća na razini pojedinaca i manjih skupina nego na razini čitavih zajednica. Smatramo da pogrebni ritual i materijalna kultura vezana uz takve cjeline jasno ukazuje da se pitanju identiteta željeznodobnih kulturnih skupina treba pristupiti analitički na razini pojedinih zajednica. Provest ćemo poredbenu analizu istovremenih i koncepcijski sličnih grobnih inventara koje pronalazimo u različitim kulturnim skupinama u različitim kontekstima pogrebnog rituala. Na taj način pokušali bismo na razini pojedinih zajednica razložiti i definirati pojedine aspekte materijalne kulture i ritualnog konteksta koji tvore identitet pokojnika. Koristeći te rezultate mogli bismo utvrditi koje od utvrđenih elemenata koristimo pri definiranju identiteta na razini pojedine zajednice, kulturne skupine ili šire, i koliko je takav pristup opravdan i univerzalno primjenjiv. Korelacijom podataka o materijalnoj kulturi, prostornoj organizaciji i ritualnom kontekstu, utvrdit ćemo pojedine elemente koji definiraju identitet pokojnika na temeljnoj razini (spol, dob, status, vrijeme ukopa) kao i na razini zajednice (status i uloga). Usporedbom podataka za pojedine zajednice provjerit ćemo postoji li specifičan skup elemenata kojima se pojedine zajednice izdvajaju unutar kulturnih skupina, odnosno postoje li poveznice između zajednica koje definiraju identitet pojedinih kulturnih skupina i izdvajaju ih jedne od drugih. Rezultat će biti set markera koji bi unutar definiranih razdoblja željeznog doba određivao identitet pokojnika u odnosu na njegovu osnovnu zajednicu i/ili kulturnu skupinu.]]></summary_hr><summary_en><![CDATA[The goal of this project is to identify the way in which the Iron Age communities expressed their identity through the burial ritual. The proposed project will research the burial ritual as a reflection of identity of Iron Age communities, mostly by applying the contextual approach. The material culture will not be viewed only as a typological category, but rather it will be linked to the context of the grave inventory and the burial ritual. The burial ritual and material culture associated with graves clearly suggest that the issue of identity of the Iron Age cultural groups should be analysed at the level of individual communities. We will carry out a comparative analysis of contemporary and conceptually similar grave inventories discovered in different burial contexts and belonging to different cultural groups. By doing so, we will attempt to examine and define some aspects of the material culture and ritual context which make up the identity of the deceased, at the level of individual communities. Such results would enable us to establish which of the identified elements are used when defining the identity at the level of a community, cultural group or a wider unit, and whether such an approach is justifiable and universally applicable. A co-relation of data concerning the material culture, spatial organization and ritual context will be used to identify elements which determine the deceased’s identity at the basic level (sex, age, time of burial) and at the level of the community (status and role). By comparing data on different communities we will check if there is a specific group of elements that sets apart some communities within a cultural group, and whether there are links between communities which define the identity of certain cultural groups. The result will consist of a set of identification markers, which will determine the identity of the deceased with respect to their basic community and/or cultural group (within the timeframe of the Iron Age).]]></summary_en></project><project>
<id>3042</id><title_hr><![CDATA[Integracijski procesi većine i manjine u etnički mješovitim zajednicama: uloga međuetničkog kontakta, percipirane prijetnje i socijalnih normi]]></title_hr><title_en><![CDATA[Integration processes of majority and minority in ethnically mixed communities: The role of interethnic contact, perceived threat and social norms]]></title_en><user_id>11126</user_id><user_firstLast_name>Dinka Čorkalo Biruški</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-4499</code><acronim><![CDATA[IntegraNorm]]></acronim><duration>01.10.2015 - 29.02.2020</duration><status>Završio</status><financ_value>72.266,13 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Psihologija, </scie_field_hr><scie_field_en>Psychology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>11293, 11284, 20494, 20454, 20453, 24512, 26898, </team_members_id><team_members_names><![CDATA[Tea Pavin Ivanec, Jasmina Tomašić  Humer, Blaž Rebernjak, Margareta Jelić, Lana Pehar Pehar, Ena Uzelac, Iva Kapović, ]]></team_members_names><keywords_hr><![CDATA[socijalna integracija, odnosi većine i manjine, međuetnički kontakt, međugrupna prijetnja, socijalne norme, obrazovanje manjina]]></keywords_hr><keywords_en><![CDATA[social integration, majority and minority relations, interethnic contact, intergroup threat, social norms, minority education]]></keywords_en><summary_hr><![CDATA[Cilj projekta je ispitati dugoročne efekte međuetničkog kontakta na ideološke i međuetničke stavove i ponašanja djece, adolescenata i njihovih roditelja, pripadnika većine i manjina, u četiri višeetničke zajednice u Republici Hrvatskoj. Jedinstven kontekst ispitivanja su manjinske i većinske škole, u kojima se nastava odvija na manjinskom jeziku (srpski, talijanski, mađarski i češki) ili pak na jeziku većine (hrvatski), a uključivanje čak četiri manjinske zajednice čini projektni prijedlog sasvim originalnim. Kao mogući mehanizmi djelovanja kontakta na međugrupne stavove i ponašanja istražit će se međugrupna prijetnja (realna i simbolička, te međugrupna tjeskoba), te, posebno, socijalne norme. Istraživanje predstavlja iskorak, jer zahvaća nekoliko aspekata međugrupne prijetnje kao posredujućeg mehanizma u odnosu međugrupnog kontakta i međugrupnih stavova i ponašanja, kao i temeljne izvore utjecaja u djece i adolescenata - roditeljske, vršnjačke i školske norme. U istraživanju će sudjelovati učenici osnovne i srednje škole, pripadnici četiri nacionalne manjine u Republici Hrvatskoj (Srbi, Talijani, Česi, Mađari) i većine, u dobi od 12 do 17 godina (N=1200) i njihovi roditelji (N=2400). Istraživanje kombinira kvalitativni i kvantitativni pristup. Kvalitativnom metodologijom (fokusne grupe, intervjui, ali i metoda opažanja) ispitat će se eksplicitne i implicitne školske norme o međuetničkom kontaktu, te potom formulirati instrument za njihovo mjerenje. Kvantitativni dio ispitivanja provest će se u dva vala, s razmakom od godine dana, te će se pratiti efekti međuetničkog kontakta na ideološke (stav prema multikulturnosti i asimilaciji), i na međugrupne stavove i ponašanja. Pri tome će se provjeriti pod kojim uvjetima, kako i koje socijalne norme utječu na vezu kontakta i međugrupnih stavova i ponašanja, te kakva je pri tome uloga međugrupne prijetnje. Rezultati projekta mogu biti relevantni za osmišljavanje integracijske uloge škole u višeetničkim zajednicama.]]></summary_hr><summary_en><![CDATA[The study aims to examine long-term effects of interethnic contact on ideological and interethnic attitudes and behaviors of majority and minority children, adolescents and their parents in four multiethnic communities in Croatia. A unique context of the study is provided by setting the research in the context of minority and majority schooling, where teaching is provided in either majority (Croatian) or minority languages (Italian, Serbian, Czech and Hungarian). Inclusion of multiple minority communities simultaneously makes this project sample rather unique. Intergroup threat (symbolic, realistic and intergroup anxiety) and especially social norms are hypothesized as being key mechanisms of influence of the interethnic contact. A novelty of the research is in encompassing multiple aspects of intergroup threat as mediating mechanisms in the link between intergroup contact and intergroup attitudes and behaviors, as well as and in assessing major sources of influence in adolescence – parental, peer and school norms. Participants will be majority and minority (Italian, Serb, Czech and Hungary) elementary and high-school students in Croatia, aged 12-17 (N=1200) and their parents (N=2400). The research combines qualitative and quantitative approach. Qualitative methods (focus groups, interviews and also observations) will be used to get an in-depth insight in the explicit and implicit contact-related school norms. These data will be used further for designing an instrument for measuring contact-related school norms. Quantitative data will be collected in a two-wave longitudinal study, and the effects of interethnic contact on ideological (assimilationism and multiculturalism) and intergroup attitudes and behaviors will be followed. It is proposed to test under what conditions, how and what social norms influence the link between the contact and intergroup attitudes and behaviors and what is the role of the intergroup threat in this context.]]></summary_en></project><project>
<id>3049</id><title_hr><![CDATA[Pravna i ekonomska analiza sustava prevencije pranja novca i financiranja terorizma ]]></title_hr><title_en><![CDATA[Legal and Economic analysis of Anti-Money Laundering and Terrorist financing system ]]></title_en><user_id>12744</user_id><user_firstLast_name>SONJA CINDORI</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2014-09</proposal_call><code>UIP-2014-09-5933</code><acronim><![CDATA[PNFT/AMLTF]]></acronim><duration>01.05.2015 - 30.04.2018</duration><status>Završio</status><financ_value>26.788,83 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Pravo, Ekonomija, Politologija, </scie_field_hr><scie_field_en>Law, Economy, Political Science, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Pravni fakultet u Zagrebu]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Law]]></institution_en><team_members_id>12804, 12764, 12757, 12756, 12763, 12817, 12755, 18954, 18955, </team_members_id><team_members_names><![CDATA[Ivan Reiner, Miran  Marelja , Meta Ahtik, Luisa Fernanda Bernat Díaz, Ozren Pilipović, Nenad Rančić, Tatjana Kovač Klemar, Jelena Dinić, TAJANA PETROVIĆ, ]]></team_members_names><keywords_hr><![CDATA[pranje novca, financiranje terorizma, analiza, procjena rizika, sumnjive transakcije, ekonometrijski modeli]]></keywords_hr><keywords_en><![CDATA[money laundering, terrorist financing, analysis, risk assessment, suspicious transaction, econometric models]]></keywords_en><summary_hr><![CDATA[Prevencija pranja novca i financiranja terorizma predstavlja novo znanstveno- istraživačko područje koje svojim sadržajem i strukturom podrazumijeva interdisciplinarnost - isprepletenost elemenata pravne podloge njegove prevencije, ekonomskih reperkusija u gospodarstvu te politološkog aspekta problematike pranja novca i financiranja terorizma. Osnovni cilj istraživanja biti će usmjeren na proučavanje zakonitosti djelovanja preventivnih mehanizama borbe protiv pranja novca i financiranja terorizma te poticanja i usmjeravanja stručnih eksperata. Osim pravnog i ekonomskog razmatranja predmetne materije u nacionalnim okvirima, uspostavit će se suradnja sa znanstvenicima iz inozemstva, s Pravnog fakulteta Sveučilišta u Ljubljani (Slovenija) i Ekonomskog fakulteta Sveučilišta Icesi u Caliu (Kolumbija).U cilju širenja spoznaja i produbljivanja suradnje nacionalnih i međunarodnih razmjera, u akademskim okvirima i suradnjom s javnim sektorom, istraživanje će obuhvatiti granu prava u okviru proučavanja financijskog prava, međunarodnog prava i pravne povijesti, dok će međunarodna ekonomija, institucionalna ekonomija i ekonomska analiza prava pružiti empirijsku podlogu znanstvenom istraživanju. Istraživanje će biti usmjereno ka empirijskoj provjeri postojećih znanstvenih teorija i stvaranju novih znanstvenih paradigmi na temelju empirijske analize.]]></summary_hr><summary_en><![CDATA[Prevention of money laundering and terrorism financing is a new scientific field which content and structure imply an interdisciplinary approach - legal approach for money laundering and terrorism financing prevention, economics for the lost revenue in the national economy and political science as another approach to studying the issue of money laundering and terrorist financing. The main aim of the research will focus on studying the legality of preventive mechanisms needed to combat money laundering and terrorist financing and to promote education of existing and new experts in the field. In addition to the legal and economic study of the subject matter at the national and international level,  cooperation with scientists from abroad – namely from Faculty of Law, University of Ljubljana (Slovenia) and Faculty of Economics, University of ICES in Cali (Colombia) will be established. In order to spread knowledge and deepen cooperation at national and international level, both in terms of academic community co-operation with the public sector, the project team will use financial law, international law and legal history for theoretical explanation of anti-money laundering and terrorist financing, while the international economy, institutional economics and economic analysis of law will be used to provide an empirical basis for scientific research.The research will be directed towards empirical verification of existing scientific theories and hopeful establishment of new scientific paradigm based on empirical analysis.]]></summary_en></project><project>
<id>3051</id><title_hr><![CDATA[Specifična obilježja obitelji u riziku: doprinos planiranju kompleksnih intervencija ]]></title_hr><title_en><![CDATA[Specific characteristics of families at risk: contribution to complex interventions planning]]></title_en><user_id>12657</user_id><user_firstLast_name>Antonija  Žižak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-9515</code><acronim><![CDATA[FamResPlan]]></acronim><duration>01.10.2015 - 27.12.2019</duration><status>Završio</status><financ_value>70.766,41 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Edukacijsko-rehabilitacijske znanosti, Pravo, Sociologija, Psihologija, Socijalne djelatnosti, </scie_field_hr><scie_field_en>Physical education and rehabilitation sciences, Law, Sociology, Psychology, Social work, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Edukacijsko-rehabilitacijski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Education and Rehabilitation Sciences]]></institution_en><team_members_id>12728, 12543, 12929, 12894, 12902, 12723, 12952, 12719, 12958, 13043, 7355, 12909, 12724, 4478, 19034, 25080, 24708, </team_members_id><team_members_names><![CDATA[Ivana Maurović, Miranda Novak, Valentina Kranželić, Anita Jandrić Nišević, Dora Dodig, Martina Lotar Rihtarić, Gabrijela Ratkajec Gašević, Anja Mirosavljević, Martina Ferić, Zoran Zoričić, Ivana Sekol, Nivex Koller-Trbović, Ivana Jeđud Borić, Oliver Kozumplik, Helena Križan, Ljubica Paradžik, Snježana Maloić, ]]></team_members_names><keywords_hr><![CDATA[obitelji u riziku, otpornost, spremnost na promjenu, zadovoljstvo životom, planiranje kompleksnih intervencija]]></keywords_hr><keywords_en><![CDATA[families at risk, resilience, readiness for change, life satisfaction, complex intervention planning]]></keywords_en><summary_hr><![CDATA[Najnovija saznanja ukazuju na potrebu istovremene usmjerenosti intervencijskih sustava za djecu, mlade i odrasle osobe s problemima u ponašanju na pojedinca s problemom i na njegovu obitelj. Stoga stjecanje novih znanja o obiteljima u riziku i razvoj novih intervencija i usluga predstavljaju stalni, kako istraživački, tako i stručni izazov.Opći cilj predloženog istraživanja je utvrditi obilježja specifičnih skupina obitelji u riziku, njihovu otpornost, spremnost na promjenu, spremnost na intervenciju i zadovoljstvo životom, kao set novijih, nedovoljno istraženih procesa koji mogu biti od važnosti za planiranje kompleksnih intervencija za te obitelji. Specifični ciljevi odnose se s jedne strane na razvoj metodologije istraživanja s obiteljima u riziku, a s druge strane na utvrđivanje relacije među navedena obilježja obitelji u riziku, što do sada nije bilo istraživano u Hrvatskoj. Istraživanje će biti provedeno na prigodom uzorku od 200 obitelji u riziku čiji je najmanje jedan član zbog problema u ponašanju korisnik intervencije u području obrazovanja, socijalne skrbi, mentalnog zdravlja i/ili pravosuđa, u Gradu Zagrebu i Zagrebačkoj županiji. Primijenit će se različite metode prikupljanja i analize kvantitativnih i kvalitativnih podataka. Zbog metodološke složenosti te sadržajne i etičke osjetljivosti nacrta istraživanja, projektne aktivnosti provodit će relativno veliki, pomno sastavljen istraživački tim čime su osigurane kompetencije u području znanstvene metodologije, teorijskih i stručnih aspekata istraživanih problema.  Uz nove spoznaje o obilježjima obitelji u riziku, doprinos istraživanja očekuje se i u području razvoja metodologije istraživanja s obiteljima i u obiteljskom okruženju. Ishodi istraživanja omogućit će kreiranje smjernica za planiranje kompleksnih intervencija s obiteljima u riziku temeljem korisničke perspektive i znanstveno utemeljenih podataka.]]></summary_hr><summary_en><![CDATA[Recent findings indicate that intervention systems for children, youth and adults with behavioural problems should focus simultaneously on the individual with the problem and his/her family. Therefore, gaining new knowledge on families at risk and development of new interventions and services present a permanent research and professional challenge.The overall objective of the proposed study is to identify characteristics of specific groups of families at risk, their resilience, readiness for change, readiness for intervention; and life satisfaction, as a set of new, under-researched processes which could be of importance for complex family interventions planning. Specific objectives on one hand relate to the family at risk research methodology development and on the other hand to determine the relationship between the aforementioned characteristics of families at risk, which were never researched in Croatia. The study sample includes 200 families at risk, with at least one family member who is, due to behavioural problems, a beneficiary of interventions in the area of education, social welfare, mental health and/or justice provision in the City of Zagreb and Zagreb County. Various qualitative and quantitative data collection and analysis methods shall be used. Due to the methodological complexity and the sensitivity of the content and research draft ethics, a relatively large, carefully selected research team will conduct the project activities, ensuring competences in the areas of research methodology, theoretical and professional aspects of the issues in focus.  In addition to the new findings on the characteristics of the families at risk, this study will contribute to the family and family environment research methodology development. The outcomes of the study will allow development of guidelines for complex family at risk interventions planning based on beneficiary perspective and scientific data.]]></summary_en></project><project>
<id>3056</id><title_hr><![CDATA[Kako praksom vođeno teorijsko istraživanje u umjetničkoj izvedbi može doprinijeti hrvatskoj znanosti ]]></title_hr><title_en><![CDATA[How Practice-led Research in Artistic Performance Can Contribute to Croatian Science ]]></title_en><user_id>753</user_id><user_firstLast_name>sibila petlevski </user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-6963</code><acronim><![CDATA[KPTIUIDHZ/ HPLRAPCCS]]></acronim><duration>15.05.2015 - 14.05.2019</duration><status>Završio</status><financ_value>65.324,77 eur</financ_value><scie_area_hr>Humanističke znanosti, Društvene znanosti, Tehničke znanosti, </scie_area_hr><scie_area_en>Humanities, Social sciences, Technological sciences, </scie_area_en><scie_field_hr>Znanost o umjetnosti, Temeljne tehničke znanosti, Politologija, Sociologija, Filozofija, Filologija, Povijest umjetnosti, Etnologija i antropologija, Kognitivna znanost, Rodni studiji, </scie_field_hr><scie_field_en>Arts, Basic engineering sciences, Political Science, Sociology, Philosophy, Philology, Art history, Ethnology and anthropology, Cognitive science, Gender Studies, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Akademija dramske umjetnosti]]></institution_hr><institution_en><![CDATA[University of Zagreb, Academy of Dramatic Art]]></institution_en><team_members_id>4706, 5264, 3463, 938, 6529, 13046, </team_members_id><team_members_names><![CDATA[Darko Lukić, Josip Stepanić, Laura Potrović, Goran Pavlić, Olga Markič, David Gazarov, ]]></team_members_names><keywords_hr><![CDATA[praksom vođeno istraživanje, umjetnička izvedba, izvedbene umjetnosti, dinamika razmjene, transfer metodologija, sistemsko modeliranje]]></keywords_hr><keywords_en><![CDATA[practice-led research, artistic performance, performing arts, dynamics of exchange, methodology transfer, systems modelling]]></keywords_en><summary_hr><![CDATA[Praksom vođeno istraživanje kao izraz, ovdje se uporablja u potkrjepu tvrdnji da je umjetnička izvedba sama po sebi oblik istraživanja i proizvodi zamjetljive rezultate istraživanja. Zanima nas kako napredak znanja kroz praksu može doprinijeti razvoju inovativnih znanstvenih metodologija. O performativnosti kao konceptu već se dugo raspravlja u okviru društvenih i humanističkih znanosti (u filozofiji jezika, teoriji izvedbe, rodnim studijima, etnografiji, antropologiji, i td.) Izvedba je više nova paradigma nego novi umjetnički oblik; ona se manje odnosi na novi fenomen, a više na novi način gledanja poznatih fenomena. Ona ovdje nije tek puki predmet proučavanja, već je interpretativna rešetka postavljena nad sam proces proučavanja (Carlson). S porastom zanimanja za sve što se pojavljuje na sučelju umjetnosti, znanosti, tehnologije i društva, uloga izvedbenog čina u znanstvenoj praksi i u proizvodnji znanja, danas zadobiva sve više pozornosti. U suvremenom europskome kontekstu, ideja &#39;&#39;performativne znanosti&#39;&#39; obogaćuje se novotehnološkim pristupima u uvidom u problem izvedbene kompleksnosti iz motrišta sistemske znanosti. Glavna je svrha našega istraživanja dati novi zamah istraživanju dinamike razmjene u tijeku umjetničke &#39;&#39;kreacije&#39;&#39;, kao i u proučavanju i reprezentaciji života. Važna hipoteza povezana s navedenim, jest u dokazivanju da dinamika transfera metodologija između umjetnosti i znanosti, metodološki &#39;&#39;interaktivni kontinuun&#39;&#39; (Newman & Benz) i &#39;&#39;petlje njegove povratne sprege&#39;&#39;, mogu olakšati maksimiziranje snage obiju metodologija. Kako bismo doprinijeli pojašnjenju  teorijskih i metodoloških problema, suradnici koji dolaze iz različitih područja istraživanja, pokušat će razviti, verifizirati, vrednovati i uporabiti u simulacijama, formalne modele kvantifikacije dinamike razmjene u tijeku izvedbe: sistemske dinamičke modele i ABM modele. ]]></summary_hr><summary_en><![CDATA[The term practice-led research is here employed to make an argument that artistic performance in itself is a form of research and generates detectable research outputs. We are interested in how advancing knowledge within practice can contribute to the development of innovative scientific methodologies. The concept of performativity has long been discussed within the social sciences and the humanities (in language philosophy, performance theory, gender studies, ethnography, anthropology, etc.). Performance is a new paradigm, not so much a new art form; it stands less for a new phenomenon than for a new observation of familiar phenomena. Here it becomes not only a subject for study but also an interpretive grid laid upon the process of study itself (Carlson). With growing interest in the interface between art, science, technology and society, the role of the performative act within scientific practice and knowledge production receives more attention these days. In the contemporary European context the idea of “performative science” is enriched with new technological approaches and systems science insight into the problem of performance complexity. The main purpose of our research is in giving new scope to exploring the dynamics of exchange in artistic ”creation”, as well as in the study and representation of lives. An important hypothesis, connected to this purpose is to prove that the dynamics of methodology transfer between arts and sciences, the methodological “interactive continuum” (Newman & Benz) and its “feedback loops” facilitate maximizing the strength of both methodologies. In order to contribute to clarification of stated theoretical and methodological problems, collaborators coming from different fields of research will try to develop, verify, validate and use in simulations, the formal models for quantification of dynamics of exchanges within performances: system dynamics model and agent based model. ]]></summary_en></project><project>
<id>3057</id><title_hr><![CDATA[Fitotoksičnost nanosrebra: mehanizmi akcije i interakcije u stanicama duhana]]></title_hr><title_en><![CDATA[Nanosilver phytotoxicity: mechanisms of action and interaction in tobacco cells ]]></title_en><user_id>11303</user_id><user_firstLast_name>Biljana Balen</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-6488</code><acronim><![CDATA[NanoPhytoTox]]></acronim><duration>01.05.2016 - 31.10.2021</duration><status>Završio</status><financ_value>112.150,77 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, Kemija, </scie_field_hr><scie_field_en>Biology, Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>4710, 6660, 3121, 4614, 12729, 12785, 21315, 5425, 27557, </team_members_id><team_members_names><![CDATA[Mirta Tkalec, Ana-Marija Domijan, Dubravko Pavoković, Petra Cvjetko, Petra Peharec Štefanić, Sandra Šikić, Renata Biba, Dora Markulin, Karla Košpić, ]]></team_members_names><keywords_hr><![CDATA[nanosrebro, biotransformacija, biomarkeri, stanična ultrastruktura, omotači, oksidacijski stress, proteomika, mehanizmi toksičnosti]]></keywords_hr><keywords_en><![CDATA[nanosilver, biotransformation, biomarkers, cell ultrastructure, coatings, tobacco, oxidative stress, proteomics, toxicity mechanisms]]></keywords_en><summary_hr><![CDATA[Male dimenzije nanočestica (NPs), rezultiraju jedinstvenim kemijskim i fizikalnim značajkama, zbog čega se one proizvode u velikim količinama i koriste u različitim proizvodima. Zbog široke upotrebe nanosrebra (AgNPs), najzastupljenijeg nanomaterijala koji ima protubakterijska i protugljivična svojstva, raste zabrinutost glede mogućih štetnih učinaka na okoliš. Do sada je objavljeno nekoliko toksikoloških studija na česticama AgNP, no još uvijek je teško donijeti konačne zaključke o njihovoj toksičnosti. AgNPs su sklone (bio)transformaciji, koja mijenja njihova svojstva i još uvijek nije jasno potječe li toksičnost od samih nanočestica ili od otpuštenih iona Ag+. Biljke kao vitalan dio ekološkog sustava imaju važnu ulogu u transportu i bioakumulaciji toksičnih tvari u hranidbeni lanac. No, studije fitotoksičnosti AgNP su malobrojne i manjkave. Nadalje, nedostaju i podaci o učincima AgNPs na važne stanične procese. Stoga u ovom projektu želimo otkriti i objasniti toksične učinke nekoliko različitih tipova AgNPs na biljke, što će doprinijeti procjeni okolišnog rizika izlaganja nanosrebru. Kao modelni organizam predlažemo duhan, ekonomski važnu biljku često korištenu u istraživanjima abiotičkog stresa. Testirat ćemo AgNPs stabilizirane različitim omotačima, kako bi otkrili utječu li različite osobine ovih nanočestica na njihovu toksičnost. Kako bismo ustanovili potječe li toksičnost AgNPs od oslobođenih iona Ag+ ili od samih nanočestica, odredit ćemo stabilnost i biotransformaciju AgNPs i ustanoviti ulaze li nanočestice u biljno tkivo odnosno stanicu. Nadalje, utvrdit ćemo ulogu oksidacijskog stresa u mehanizmu toksičnosti nanosrebra te dolazi li tijekom izlaganja nanosrebru do promjene u sastavu proteina. Na temelju dobivenih rezultata definirat ćemo biomarkere fitotoksičnosti AgNPs koji bi se mogli koristiti u biomonitoringu okoliša. Dobiveni rezultati moći će se primijeniti za procjenu sigurnosti korištenja nanočestica srebra.]]></summary_hr><summary_en><![CDATA[The small size of nanoparticles (NPs) results in unique chemical and physical characteristics, which is why they are produced in large quantities for implementation in various products. Due to widespread use of silver nanoparticles (AgNPs), the dominating nanomaterial with antibacterial and antifungal properties, there is a concern regarding its potential detrimental impacts on the environment. Although there have been a lot of toxicological studies published on AgNPs, it is still difficult to draw conclusions about their toxicity. AgNPs are prone to (bio)transformation, which modifies their properties and it is not clear whether toxicity results from the nanoparticles or from Ag+ dissociation. Besides being the vital part of healthy ecosystems, plants play a significant role in transport and bioaccumulation of toxic substances in food chains, but toxicological studies of AgNPs conducted on plants are scare and inconclusive. Moreover, there is a lack of information about effects of AgNPs on important cellular processes. Therefore, in this project we aim to reveal and explain the toxicity of a set of diverse AgNPs to plants in order to contribute to the environmental hazard assessment of AgNP. As the model organism we propose tobacco, an economically interesting plant, frequently used in stress research. We will investigate AgNPs with different coatings, used to enhance NP stability, to reveal whether those characteristics are determinants of toxicity. Stability and biotransformation of AgNPs as well as their uptake in the cells will be studied and correlated with AgNPs-induced effects to distinguish between particle and Ag+ toxicity. We will establish the involvement of oxidative stress in the mechanism of toxicity as well as possible proteomic changes. The results will be used to define biomarkers of AgNP-induced phytotoxicity, which could be useful for environmental biomonitoring. Also, results can be applied to estimate the possibility of use and safety of AgNPs.]]></summary_en></project><project>
<id>3061</id><title_hr><![CDATA[Uloga stresnog proteina Hsp70 u imunosno-upalnom odgovoru kod kronične opstrukcijske plućne bolesti]]></title_hr><title_en><![CDATA[The role of stress protein Hsp70 in immune and inflammatory responses in chronic obstructive pulmonary disease]]></title_en><user_id>12345</user_id><user_firstLast_name>Lada Rumora</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-1247</code><acronim><![CDATA[Hsp70COPD]]></acronim><duration>01.12.2015 - 30.11.2019</duration><status>Završio</status><financ_value>132.720,55 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, Farmacija, </scie_field_hr><scie_field_en>Basic Medical Sciences, Pharmaceutical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Farmaceutsko-biokemijski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Pharmacy and Biochemistry]]></institution_en><team_members_id>13256, 3520, 12546, 2629, 12800, 13149, 12859, 7144, 3452, 12717, 3517, 20407, 25103, </team_members_id><team_members_names><![CDATA[Ivana Čepelak, Andrea Hulina, Anita Somborac Bačura, Tihana Žanić Grubišić, DANIELA JAKŠIĆ DESPOT, Dubravko Jelić, Martina Bosnar, Sanja Popović-Grle, Miroslav Samarzija, Heijink Irene Hilde, Marija Grdić Rajković, Andrea  Vukić Dugac, Iva Hlapčić, ]]></team_members_names><keywords_hr><![CDATA[Hsp70, KOPB, upala, TLR, NLRP3 inflamasom, signalne molekule, stanično umiranje, biomarkeri]]></keywords_hr><keywords_en><![CDATA[Hsp70, COPD, inflammation, TLR, NLRP3 inflammasome, signalling molecules, cell death, biomarkers]]></keywords_en><summary_hr><![CDATA[Kroničnu opstrukcijsku plućnu bolest (KOPB) karakterizira stalno ograničenje protoka zraka koje je povezano s pojačanom kroničnom upalom.Glavna hipoteza ovog istraživanja je da je pojačan imunosno-upalni odgovor posljedica povišenih koncentracija izvanstaničnog Hsp70 (eHsp70) u bolesnika s KOPB-om.Cilj in vitro istraživanja ispitati je mehanizam djelovanja eHsp70 na plućnim i krvnim stanicama. Stoga će se pratiti aktivacija TLR2 i TLR4 receptora, NLRP3 inflamasoma i signalnih molekula MAPK i NF-kappaB, koje potiču otpuštanje upalnih citokina (TNFalpha, IL-6, IL-1alpha, IL-1beta). Kako bi se razjasnilo funkcionalno značenje aktivacije navedenih molekula, koristit će se specifični agonisti, antagonisti i inhibitori. Također će se istraživati citotoksičnost eHsp70 te će se proučiti različiti načini umiranja stanica (apoptoza, nekroptoza, piroptoza).Cilj ex vivo istraživanja ispitati je povezanost eHsp70 i drugih upalnih parametara s klinički značajnim ishodima KOPB-a. Predloženo istraživanje longitudinalno je praćenje sistemskih upalnih biomarkera u skupinama bolesnika u stabilnoj fazi KOPB-a te zdravih ispitanika (pušača i nepušača). Spirometrijska mjerenja vršit će se jednom godišnje tijekom tri godine, a krv će se vaditi na početku istraživanja i nakon godine dana. Genska komponenta bolesti istražit će se ispitivanjem ekspresije (RT-qPCR) i polimorfizama (PCR-RFLP) gena za Hsp70, TLR2 i TLR4. Sistemska upala ispitat će se određivanjem upalnih DAMP molekula (eHsp70, eATP, IL-1alpha), citokina (TNFalpha, IL-6, IL-1beta) te općih upalnih biomarkera (leukociti, CRP, fibrinogen).Smatramo da će rezultati ovog istraživanja doprinijeti boljem razumijevanju sistemskog upalnog fenotipa u KOPB-u te da će pripomoći individualizaciji terapijskog pristupa kao i poboljšanju značajnih kliničkih ishoda KOPB-a.]]></summary_hr><summary_en><![CDATA[Chronic obstructive pulmonary disease (COPD) is characterized by persistent airflow limitation associated with an enhanced chronic inflammation.Main hypothesis of our research is that strong activation of immune and inflammatory responses is result of increased levels of extracellular Hsp70 (eHsp70) in COPD patients.The objective of in vitro investigations is to explore underlying mechanisms of eHsp70 effects in pulmonary and peripheral blood cells. Therefore we will monitor activation of TLR2 and TLR4 receptors, NLRP3 inflammasome, and signalling molecules MAPKs and NF-kappaB, important for pro-inflammatory cytokines release (TNFalpha, IL-6, IL-1alpha, IL-1beta). To elucidate the functional significance of molecules’ activation in eHsp70-induced inflammation, we will use specific agonists, antagonists and inhibitors. We will also explore eHsp70 cytotoxicity and differentiate between various modes of cell death (apoptosis, necroptosis, pyroptosis).The objective of ex vivo investigations is to associate eHsp70 and other pro-inflammatory parameters with clinically relevant COPD outcomes. The proposed study provides longitudinal investigations of systemic inflammatory biomarkers in stabile COPD patients, and smoking and non-smoking controls. Spirometry measurements will be performed annually during three year follow up, and blood will be collected at the recruitment and after one year. Genetic component of the disease will be explored by assessing expression (RT-qPCR) and polymorphisms (PCR-RFLP) of Hsp70, TLR2 and TLR4 genes. Systemic inflammation will be evaluated by pro-inflammatory DAMPs (eHsp70, eATP, IL-1alpha), cytokines (TNFalpha, IL-6, IL-1beta) and general biomarkers (leukocytes, CRP, fibrinogen) determination.We believe that obtained results will provide new information on the systemic inflammatory COPD phenotype, which might help to individualize therapeutic strategy, and to improve relevant clinical outcomes of the disease.]]></summary_en></project><project>
<id>3067</id><title_hr><![CDATA[Razvoj supramolekulskih receptora kationa i aniona]]></title_hr><title_en><![CDATA[Development of Supramolecular Receptors for Cations and Anions]]></title_en><user_id>7690</user_id><user_firstLast_name>Vladislav Tomišić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-7309</code><acronim><![CDATA[SupraCAR]]></acronim><duration>01.06.2015 - 31.05.2019</duration><status>Završio</status><financ_value>127.413,90 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>4270, 12766, 12769, 5334, 12384, 2558, 12733, 11281, 2593, 3260, </team_members_id><team_members_names><![CDATA[Branimir Bertoša, Nikola Cindro, Renato Tomaš, Josip Požar, Gordan Horvat, Marina Tranfić Bakić, Nikola Bregović, Vlatka Gvozdić, Marijana Jukić, Katarina Pičuljan, ]]></team_members_names><keywords_hr><![CDATA[receptori iona, kaliksareni, dehidracetna kiselina, kompleksiranje, solvatacija, vodikove veze, termodinamika  ]]></keywords_hr><keywords_en><![CDATA[ion receptors, calixarenes, dehydroacetic acid, complexation, solvation, hydrogen bonding, thermodynamics]]></keywords_en><summary_hr><![CDATA[Razvoj efikasnih i selektivnih receptora nabijenih kemijskih vrsta od velike je važnosti. U okviru ovog projekta dizajnirat će se, sintezirati i karakterizirati brojni takvi spojevi. Priredit će se niz novih derivata kaliksarena koji bi trebali efikasno i selektivno vezati razne katione i anione. Neki od tih spojeva predviđeni su da mogu poslužiti u analitičke svrhe, posebice kao ekstraktanti, drugi će sadržavati fluorescentne ili aminokiselinske podjedinice, dok će prilikom dizajna jednog dijela kaliksarenskih derivata posebna pažnja biti usmjerena poboljšanju njihove topljivosti u vodi. Također će se prirediti niz derivata dehidracetne kiseline kao anionskih receptora koji će sadržavati aminske, amidne, ureidne i tioureidne podjedinice. Kompleksacijski afiniteti svih navedenih spojeva prema raznim supstratima proučit će se sveobuhvatnim pristupom koji uključuje termodinamička, komputacijska i strukturna istraživanja. Koristit će se brojne spektroskopske i elektrokemijske metode, kao i (mikro)kalorimetrija, što će omogućiti određivanje pouzdanih termodinamičkih podataka (konstante stabilnosti, standardne Gibbsove energije, entalpije i entropije reakcija kompleksiranja i otapanja). Bit će provedene i simulacije molekulske dinamike istraživanih sustava, što će pripomoći dizajnu novih spojeva te interpretaciji eksperimentalnih nalaza. Pored toga, uz rezultate postignute spektroskopijom NMR te rentgenskom strukturnom analizom, te će simulacije pružiti uvid u strukturne karakteristike receptora i njihovih kompleksa. Posebna će pažnja biti posvećena utjecaju vodikovih veza i solvatacije na ravnoteže reakcija kompleksiranja. U tu svrhu koristit će se brojna otapala različitih solvatacijskih svojstava i afiniteta za stvaranje vodikovih veza. Očekuje se da će dobivene termodinamičke informacije omogućiti stjecanje detaljnog uvid u reakcije kompleksiranja, kao i utjecaj otapala na njihov ishod, što bi trebalo olakšati i ubrzati daljnji razvoj supramolekulskih receptora.]]></summary_hr><summary_en><![CDATA[The importance of development of efficient and selective receptors of charged species has been widely recognised. In the framework of this project, a variety of such compounds will be designed, synthesised, and characterised. A series of novel calixarene derivatives capable of strongly and selectively binding cations and anions will be prepared. Some of these compounds are aimed to be efficient liquid-liquid extraction agents whereas the others will be designed to be water-soluble or to bear fluorescent and amino-acid substituents. Another class of anion receptors which will be synthesised comprises amine, amide, urea, and thiourea derivatives of dehydroacetic acid. The complexation abilities of all the compounds mentioned towards various substrates will be explored by using an integrated approach which includes thermodynamic, computational, and structural studies. A number of spectroscopic and electrochemical methods as well as (micro)calorimetry will be employed. That should yield detailed and reliable thermodynamic data (stability constants, reaction and solution Gibbs energies, enthalpies and entropies). In order to facilitate the design of the targeted molecules and to assist the interpretation of the experimental results, the molecular dynamics simulations of the systems studied will be carried out. This will, together with the results of NMR studies and that of solid-state X-ray diffraction investigations, also ensure information about structural characteristics of the receptors and their complexes. Particular attention will be focused on the hydrogen-bonding and solvation effects on the equilibria of binding reactions. For that reason, many solvents with different solvation and hydrogen-bonding affinities will be used. The obtained thermodynamic information is expected to provide a detailed insight into the complexation processes and the influence of medium on the reactions studied, which will allow further development of efficient supramolecular receptors.]]></summary_en></project><project>
<id>3070</id><title_hr><![CDATA[Vojnički život i slike ratnika u hrvatskom pograničju od 16. stoljeća do 1918.]]></title_hr><title_en><![CDATA[Military Life and Warrior Images in Croatian Borderlands from the 16th Century until 1918]]></title_en><user_id>265</user_id><user_firstLast_name>Alexander Buczynski</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-3675</code><acronim><![CDATA[MLWICB]]></acronim><duration>01.05.2015 - 30.04.2019</duration><status>Završio</status><financ_value>73.501,89 eur</financ_value><scie_area_hr>Humanističke znanosti, Društvene znanosti, </scie_area_hr><scie_area_en>Humanities, Social sciences, </scie_area_en><scie_field_hr>Povijest, Sociologija, Demografija, </scie_field_hr><scie_field_en>History, Sociology, Demography, </scie_field_en><institution_hr><![CDATA[Hrvatski institut za povijest]]></institution_hr><institution_en><![CDATA[Croatian Institute of History]]></institution_en><team_members_id>382, 461, 401, 532, 418, 338, 1172, 1389, 1078, 3212, 12934, 13032, 13197, 1501, 21408, </team_members_id><team_members_names><![CDATA[Lovorka Čoralić, Stjepan Matković, Maja Katušić, Vedran Klaužer, Filip Novosel, Ruža Radoš, Tado Oršolić, Nikola Markulin, Domagoj Madunić, Juraj Balić, Vlad Vasile Popovici, D.B.G Heuser, Ferenc Végh, Arijana Kolak Bosnjak, Goran Ovčariček, ]]></team_members_names><keywords_hr><![CDATA[kulturna povijest, povijesna demografija, Habsburška Monarhija, Venecija, Vojna krajina, Dalmacija, gerila, vojni popisi, vojna revolucija, novine]]></keywords_hr><keywords_en><![CDATA[cultural history, historical demography, Habsburg Monarchy, Venice, Military Frontier, Dalmatia, guerilla, muster rolls, military revolution, news]]></keywords_en><summary_hr><![CDATA[Prinosi vojnika s hrvatskog pograničja u vojnim postrojbama Habsburške Monarhije, Mletačke Republike, Osmanskog Carstva i Francuskog Carstva neprijeporna su činjenica. Zahvaljujući opsežnom i vremenski kontinuirano sačuvanom arhivskom gradivu koje se odnosi na razdoblje ranog novog vijeka i dugog 19. stoljeća, ta se problematika može sustavno istraživati primjenom multidisciplinarnih metoda. Cilj ovog projekta je istražiti demografske, društveno-ekonomske i političke prilike u hrvatskom pograničju, kao i utvrditi uzročno-posljedične veze između navedenih prilika (razvojnih sastavnica) koje su činile svakodnevnicu hrvatskih vojnika i kreirale njihov identitet. Istraživanje će se usredotočiti na Ličku i Otočku pukovniju u Vojnoj krajini, Zadar i Kotor kao središnja mletačka vojna uporišta na istočnoj obali Jadrana, Dubrovačku Republiku te Dalmaciju u vrijeme austrijske i francuske uprave. Rekonstrukcija svakodnevice i identiteta pripadnika vojničkog društva objedinit će: 1. demografska kretanja (natalitet, fertilitet i mortalitet), migracije, društveno-ekonomski kontekst (dobna, spolna i profesionalna struktura); 2. vojni i ratni kontekst (vojna organizacija i obuka, “mali rat“ – “partizanski način ratovanja“ – umijeće ratovanja, imidž i samosvijest hrvatskih vojnika); 3. geo-politički kontekst (upravno-pravna podjela, tranzicije vlasti). Jedan od temeljnih ciljeva istraživačkog tima jest znanstveno obraditi te kroz bazu podataka prikazati što veći broj vojnih popisa, matičnih knjiga, popisa stanovništva, popisa stradalnika, zemljišnih knjiga koji se odnose na Ličku i Otočku pukovniju, Zadar, Dubrovačku Republiku i Kotor. Rečeni bi izvori, odnosno podatci, bili kreirani i dostupni u on-line bazi otvorenog pristupa te integrirani u svjetske mreže sličnih baza kao što su EHPS-Net i MOSAIC i kao takvi služili bi multidisciplinarnoj svrsi.]]></summary_hr><summary_en><![CDATA[The contribution of soldiers from Croatian borderlands to the armed forces of the Habsburg Monarchy, Republic of Venice, Ottoman Empire and French Empire is beyond dispute. Thanks to comprehensive and continuous archive records relevant to the early modern period and long nineteenth century, this issue can be thoroughly researched on a multidisciplinary level. This project aims to explore demographic, socio-economic and political circumstances in Croatian borderlands, and to examine cause and effect relationships between these circumstances (developmental components) that made up the everyday life of Croatian soldiers, their families and households, and formed their identity. Research will focus on the Otočac and Lika Regiments of the Military Frontier, Zadar and Kotor as central strongholds of the Republic of Venice on the East Adriatic, the Republic of Dubrovnik and Dalmatia during the French and Austrian administration. The reconstruction of everyday life and the identity of the martial people that inhabited these borderlands will include: 1. demographic data (birth rates, fertility and mortality), migrations and the socio-economic context (age, gender and professional structure); 2. the military and war context (military organization and training, la petite guerre - partisan warfare - and the art of war, images and self-awareness of Croatian soldiers); 3. the geo-political context (administrative and legal organization, government transitions). One of the main objectives of the research team is to process a large quantity of muster rolls and other military lists, birth, marriage and death registers, casualty lists, land registers etc, covering the Otočac and Lika Regiments, Zadar, Dalmatia, Republic of Dubrovnik and Kotor in order to create an open access database that can be integrated within networks as EHPS-Net and MOSAIC and will thus serve a multidisciplinary purpose.]]></summary_en></project><project>
<id>3073</id><title_hr><![CDATA[Potencijali i prepreke razvoja socijalnih supermarketa u Srednjoj i istočnoj Europi]]></title_hr><title_en><![CDATA[Potentials and obstacles of Social Supermarkets Development in Central and Eastern Europe]]></title_en><user_id>11297</user_id><user_firstLast_name>Blaženka Knežević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2014-09</proposal_call><code>UIP-2014-09-4057</code><acronim><![CDATA[SSMCEE]]></acronim><duration>01.06.2015 - 31.05.2018</duration><status>Završio</status><financ_value>60.258,84 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, Socijalne djelatnosti, </scie_field_hr><scie_field_en>Economy, Social work, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Ekonomski fakultet u Zagrebu]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Economics and Business]]></institution_en><team_members_id>13165, 13604, 13624, 13029, 13258, 6450, 13693, 13726, 13707, 13589, 13713, 13733, 13735, 13734, 13745, 13744, 21404, </team_members_id><team_members_names><![CDATA[Anita Pavković, Zoran Šućur, SANDA RENKO, Petra Škrobot, Mia  Delić, Ivana Marić, Wach Krzysztof, Marek Szarucki, Vida Davidavičiene, MAJA KLINDŽIĆ, Nika Šimurina, Jurgita  Raudeliuniene, Zoran Bogetić, Grazyna  Śmigielska, Goran Petković, Jelena Stankevičiene , Eva  Pavic, ]]></team_members_names><keywords_hr><![CDATA[maloprodaja, oblici maloprodaje, društvena odgovornost, socijalni supermarketi, socijalne inovacije]]></keywords_hr><keywords_en><![CDATA[retailing, retail formats, social responsibility, social supermarkets, social innovations]]></keywords_en><summary_hr><![CDATA[Ekonomska kriza uzrokovala je porast nezaposlenosti i povećanje siromaštva u Europskoj uniji. S druge strane, tradicionalni kanali distribucije obično stvaraju viškove koji se mogu učinkovitije iskoristiti. Istraživanja pokazuju da socijalne samoposluge, kao novi maloprodajni oblik, postaju sve važniji čimbenik u smanjenju siromaštva u cijeloj Europi putem učinkovitije raspodjele stvorenih viškova roba. Socijalne samoposluge po svojoj osnovnoj svrsi i načinu poslovanja, značajno se  razlikuju u odnosu na tradicionalne maloprodajne oblike, a u postojećoj znanstvenoj literaturi još uvijek nisu istražene u dovoljnoj mjeri, posebice u zemljama Srednje i istočne Europe. Kako socijalne samoposluge temelje svoje djelovanje na filantropskim osnovama, volontiranju i donacijama, a već na nekim tržištima značajno utječu na strukturu prihoda tradicionalnih maloprodavača, ova tema zahtijeva multidisciplinarni pristup kako bi se: (a) pojasnila njihova trenutna pozicija i njihov utjecaj na opću socio-ekonomsku situaciju na pojedinim tržištima, (b) istražio pravni okvir koji je utemeljen u onim zemljama u kojima su socijalni supermarketi postigli visok stupanj razvoja, posebno u području poreznog zakonodavstva i zakonodavstva prava potrošača, (c) istaknula pitanja upravljanja u vezi organizacije rada volontera ili zaposlenika, i (d) objasnili specifični problemi učinkovite organizacije ulazne logistike te distribucije roba i usluga unutar socijalnih supermarketa. Zato će projektni tim obuhvatiti stručnjake iz područja trgovine, upravljanja maloprodajom, upravljanja neprofitnim organizacijama, korporativnih financija, fiskalnih sustava i socijalnog rada iz nekoliko znanstvenih institucija iz četiri države Srednje i istočne Europe.]]></summary_hr><summary_en><![CDATA[The ongoing economic crisis caused the rising unemployment and the increasing poverty in the European Union. On the other hand, the traditional distribution channels usually generate surpluses that can be effectively used to decrease problems of poverty. Research studies show that Social supermarkets, as a new retail, are becoming increasingly important factor in reducing poverty across Europe throughout more efficient distribution of generated surpluses of goods. Social supermarkets at their core purpose and mean of operations are substantially different compared to the traditional retail formats, and in the current scientific literature they have not been sufficiently investigated so far, especially in Central and Eastern European countries. As social supermarkets base their operation on philanthropic foundations, volunteering and donations, and already in some markets significantly affect the structure of revenues of the traditional retailers, this topic requires a multidisciplinary approach in order: (a) to clarify their current position and their impact the general socio-economic situation in the particular markets, (b) to investigate the legal framework that has been established by those countries in which social supermarkets reached a high level of development, particularly in the area of tax legislation and consumer rights legislation, (c) to assess management issues regarding work organization of volunteers or employees, and (d) to explain particular problems of the effective organization of input logistics and distribution of goods and services within social supermarkets. Therefore, the project team will include experts from the fields of retailing, retail management, management of nonprofit organizations, corporate finance, fiscal systems and social work from several scientific institutions from four Central and Eastern European countries.]]></summary_en></project><project>
<id>3076</id><title_hr><![CDATA[Molekularni mehanizmi alternativne raspodjele elektrona u fotosintezi]]></title_hr><title_en><![CDATA[Exploring novel molecular mechanisms of alternative electron partitioning in photosynthesis]]></title_en><user_id>455</user_id><user_firstLast_name>Hrvoje Fulgosi</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-1173</code><acronim><![CDATA[PHOTOSYNTH]]></acronim><duration>01.09.2015 - 30.11.2019</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>1001, 998, 1266, 5629, 25066, </team_members_id><team_members_names><![CDATA[Lea Vojta, Hrvoje Lepeduš, Sonja Veljović Jovanović, Wolfgang Bilger, Marija Vidović, ]]></team_members_names><keywords_hr><![CDATA[oksigena fotosinteza, kloroplasti, tok elektrona, FNR, ROS, rodanaza, sortiranje proteina, transgenične biljke, Arabidopsis thaliana]]></keywords_hr><keywords_en><![CDATA[oxygenic photosynthesis, chloroplasts, electron flow, FNR, ROS, rhodanese, protein sorting, transgenic plants, Arabidopsis thaliana]]></keywords_en><summary_hr><![CDATA[Konačni prijenos fotosintetskih elektrona s feredoksina na NADP+ odvija se putem enzima feredoksin:NADP+ oksidoreduktaze (FNR). FNR je privučen na tilakoide pomoću integralnog proteina tilakoidnih membrane sličnog rodanazama, TROL-a, i solubilnog proteina Tic62. TROL je nedavno okarakterizirala naša grupa. FNR također predstavlja poveznicu između svjetlosnih reakcija i generalnog metabolizma (kao što je fiksacija ugljika, metabolizam dušika, biosinteza masnih kiselina i klorofila). U ovom projektu pratimo sudbinu elektrona nizvodno od fotosustava I u odsustvu TROL-a. Da bismo proučili in vivo funkcije TROL-a i njegovih domena koristit ćemo genski “knock-out” i “knock-in” pristup u modelnoj biljci Arabidopsis thaliana. Naša hipoteza je da je FNR-TROL interakcija dinamičma, slična interakciji FNR-Tic62, i usklađena s mijenjanjem uvjeta osvjetljenja u okolišu. Nadalje, predlažemo da je lumenu izložena rodanazna domena TROL-a uključena u prepoznavanje redoks signala, dok je prolinom bogata pokretna spona, ispred motiva koji veže FNR za membranu, odgovorna za dinamičko vezanje FNR-a i/ili privlačenje FNR-a u različite membranske domene. Koristit ćemo razrađene biokemijske i biofizičke pristupe za kvantifikaciju stvaranja slobodnih radikala i protoka i raspodjele elektrona u različitim mutantama TROL-a. Cilj nam je pokazati da je točka grananja TROL-FNR integrirana u biljni odgovor na stress. Također, želimo pokazati da dinamičko vezanje i otpuštanje FNR-a s TROL-a može kontrolirati protok elektrona prije aktivacije puta pseudocikličkog prijenosa elektrona. Ovaj mehanizam vjerojatno nije uočen u dosadašnjim modelima toka elektrona u oksigenoj fotosintezi.]]></summary_hr><summary_en><![CDATA[In photosynthesis, final electron transfer from ferredoxin to NADP+ is accomplished by the flavo enzyme ferredoxin:NADP+ oxidoreductase (FNR). FNR is recruited to thylakoid membranes via integral membrane thylakoid rodanese-like protein TROL and soluble Tic62. TROL protein has recently been characterized by our group. FNR also represents a link between light-driven reactions and general metabolism (e.g. carbon fixation, nitrogen metabolism and fatty acid and chlorophyll biosynthesis). In this project, we address the fate of electrons downstream of photosystem I when TROL is absent. We will employ gene knock-out and knock-in approaches in the model plant Arabidopsis thaliana to study in vivo functions of TROL and its domains. We hypothesize that the interaction of FNR with TROL is dynamic, similar to FNR-Tic62 association, and in synchrony with changing environmental light conditions. Further, we propose that thylakoid lumen-exposed rhodanese domain of TROL is involved in perception of redox signals, while proline-rich swivel preceding FNR membrane attachment motif is responsible for the dynamic FNR biding and/or recruitment of FNR into different membrane domains. We will use elaborate biochemical and biophysical approaches to quantify free radical formation and electron flow and partitioning in various TROL mutants. We will aim to demonstrate that TROL-FNR branch point is integrated into plant stress responses. Finally, we want to demonstrate that the dynamic binding and release of FNR from TROL can control the flow of electrons prior to activation of the pseudo-cyclic electron transfer pathway. This mechanism may have been overlooked in present models of electron flow in oxygenic photosynthesis. ]]></summary_en></project><project>
<id>3079</id><title_hr><![CDATA[Sirtuin3 kao posrednik mitohondrijske funkcije u estrogen-ovisnoj otpornosti na oksidativni stres i prehranu s visokim udjelom masti]]></title_hr><title_en><![CDATA[Sirtuin 3 as a mediator of mitochondrial function in estrogen-dependent resistance to oxidative stress and high-fat diet]]></title_en><user_id>656</user_id><user_firstLast_name>Tihomir  Balog</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-4533</code><acronim><![CDATA[SuMERA]]></acronim><duration>01.09.2015 - 31.01.2020</duration><status>Završio</status><financ_value>131.429,21 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, Clinical sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>703, 3299, 660, 3410, 3543, 3434, 941, 21332, </team_members_id><team_members_names><![CDATA[Sandra Sobočanec, Marina Korolija, Željka  Mačak Šafranko, Marijana  Popović Hadžija, Borka Kušić, Ivana Grbeša, Ana Šarić, Iva Škrinjar, ]]></team_members_names><keywords_hr><![CDATA[sirtuini, mitohondriji, estrogen, RKV, starenje, oksidativni stres]]></keywords_hr><keywords_en><![CDATA[sirtuin, mitochondria, estrogen, ROS, aging, oxidative stress]]></keywords_en><summary_hr><![CDATA[Sirtuini čine obitelj proteina koji imaju važnu i dobro istraženu ulogu za regulaciju procesa starenja u kvascima i D. melanogaster. U višim organizmima njihova je uloga u starenju znatno slabije istražena. Sirtuin 3 (SIRT3) je jedini član porodice proteina SIRT čija se aktivnost može povezati sa dužinom života u ljudi. SIRT3 je glavni regulator mitohondrijske funkcije, te ima važnu ulogu u održavanju oskidacijsko-redukcijske ravnoteže u mitohondrijima. Poremećaj oksidacijsko-redukcijske ravnoteže u stanici zbog povećanog stvaranja reaktivnih kisikovih vrsta (ROS), uzrokuje oksidacijski stres koji za posljedicu ima oksidacijska oštećenja proteina, lipida i nukleinskih kiselina, te doprinosi smanjenu mitohondrijske funkcije. Progresivno nakupljanje oksidacijskih oštećenja u stanici i slabljenje funkcije mitohondrija prethodi nastanku bolesti povezanih sa starenjem. Ženski spol općenito, pokazuje manji stupanj pojavnosti bolesti i patologija povezanih sa starenjem, što se pripisuje zaštitnoj ulozi ženskih spolnih hormona, u prvom redu estrogena (E2). Uloga E2 u zaštiti stanica od štetnog djelovanja reaktivnih vrsta utvrđena je na velikom broju modela. Poznato je da E2 svoju zaštitnu ulogu ostvaruje prvenstveno pojačavajući učinkovitost pretvorbe energije u mitohondrijima i aktivacijom zaštitnih mehanizama u stanici, međutim nije poznato sudjeluje li u tim procesima protein SIRT3. Naš cilj utvrditi ulogu proteina SIRT3 u zaštiti stanica od oksidacijskog stresa posredovanoj estrogenom na modelima in vitro i in vivo.U svrhu određivanja povezanosti između SIRT3, te zaštitnog učinka estrogena na funkciju mitohondrija i otpornost na oksidacijski stres, planiramo koristiti farmakološki, nutritivni i genetički pristup. Uspješan završetak planiranog projekta znatno bi doprinjeo razumijevanju mehanizama djelovanja mitohondrijskog proteina SIRT3, te njegove uloge kao potencijalne farmakološke ciljne molekule. Nadalje, razumjevanije razlika između zaštitnog i štetnog djelovanja estrogena nužan je preduvjet za razvoj lijekova koji bi pomogli u liječenju i sprečavanju bolesti povezanih sa starenjem, kod kojih bi štetan utjecaj estrogena bio sveden na minimum. ]]></summary_hr><summary_en><![CDATA[Sirtuin protein family is found to be involved in aging process in yeast and D. melanogaster, while their role in higher organisms is less explored. Sirtuin3 (SIRT3) is the only member of sirtuin family linked to longevity in humans. In addition, important cellular and mitochondrial processes, including reactive oxygen species (ROS) generation are integrated through SIRT3. The excessive production of ROS leads to oxidative stress, a crucial event that contributes to mitochondrial dysfunction and age-related pathologies. Females show lower incidence of some age-related diseases that is attributed to protective effect of sex hormones. Estrogen (E2), a female sex hormone, has well established cytoprotective effect during oxidative stress. However, the mechanisms by which E2 is protective remains elusive. Although E2-dependent protection includes improvement of mitochondrial function, it is not clear whether SIRT3 participates in these events. We propose that sex-related resistance to oxidative stress occurs by E2-dependent improvement of mitochondrial function, mediated by SIRT3. We aim to define the role of SIRT3 on mitochondrial function in E2-dependent resistance to oxidative stress both in vitro and in vivo. To validate this hypothesis we will utilize pharmacological, dietary and genetic approaches to establish role of SIRT3 in E2-dependent resistance to oxidative stress. These informations will indicate if direct link between E2, SIRT3, mitochondrial function and resistance to oxidative stress exists. Successful completion of these specific aims will contribute to mechanistic understanding of the role of mitochondrial fidelity protein SIRT3, as a potential pharmacological target. Moreover, distinguishing the pathways involved in beneficial and detrimental effects of E2 is crucial for developing drug therapies that will help to retard aging with only minimal deleterious effects caused by E2]]></summary_en></project><project>
<id>3080</id><title_hr><![CDATA[Minimalni umjetni enzimi: Proširenje primjene &#39;&#39;posredne indukcije&#39;&#39; na nove supstrate i nove asimetrične reakcije]]></title_hr><title_en><![CDATA[Minimal Artificial Enzymes: Expanding the Application of &#39;&#39;Backdoor Induction&#39;&#39; through new Substrates and new Asymmetric Reactions]]></title_en><user_id>355</user_id><user_firstLast_name>Srećko Kirin</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-1461</code><acronim><![CDATA[MArtEn]]></acronim><duration>01.06.2015 - 30.09.2019</duration><status>Završio</status><financ_value>104.187,40 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>3009, 2927, 368, 2855, 21301, 21300, 463, </team_members_id><team_members_names><![CDATA[Zoran Kokan, Berislav Perić, Zoran Glasovac, Dražen Vikić-Topić, Saša Opačak, Natalija Pantalon Juraj, Goran Miletić, ]]></team_members_names><keywords_hr><![CDATA[aminokiseline, asimetrična kataliza, bioanorganska kemija, koordinacijska kemija, supramolekulska kemija]]></keywords_hr><keywords_en><![CDATA[Amino Acids, Asymmetric Catalysis, Bioinorganic Chemistry, Coordination Chemistry, Supramolecular Chemistry]]></keywords_en><summary_hr><![CDATA[Svrha ovog projekta je razvoj kiralnih katalizatora prijelaznih metala s posebnim naglaskom na inspiraciju iz prirode. Predložena je struktura beta-okreta kao ključno obilježje kiralnih katalizatora koji oponašaju umjetne enzime s minimalnom, ali fukcionalnom kiralnom vanjskom koordinacijskom sferom. Ovi minimalni umjetni enzimi mogli bi naći primjenu u asimetričnoj sintezi lijekova ili međuprodukata lijekova proizvedenih u farmaceutskoj industriji.U asimetričnoj katalizi opće je prihvaćeno da kiralna informacija mora biti prisutna što bliže koordinacijskoj sferi katalitičkog metala. Mi propitujemo ovo važno načelo i koristimo katalitički metalni centar koji je samo prokiralan. Kiralna informacija se prenosi &#39;&#39;posrednom indukcijom&#39;&#39; putem vodikovih veza udaljenih aminokiselina koje predstavljaju vanjsku koordinacijsku sferu. Preliminarni rezultati snažno podržavaju izvodljivost projekta, jer pokazuju da jednostavni biokonjugati monodentatnih trifenilfosfanskih liganada mogu tvoriti supramolekulske L2M komplekse s Rh(I) koji selektivno kataliziraju modelnu reakciju asimetričnog hidrogeniranja sa značajnim utjecajem redosljeda udaljenih aminokiselina na selektivnost [Kirin and Kokan, RSC Adv. 2012, Eur. J. Org. Chem. 2013 i Organometallics 2014; e.v. do 84 %].U okviru ovog projekta, predloženo je značajno proširenje uključujući (i) uporebu novih biokonjugata liganada s fosfornim ili dušikovim donorskim atomom, (i) uporeba novih supstrata te (iii) upotreba drugih prijelaznih metala za različite asimetrične reakcije, kao što su Ru(II)-katalizirano hidrogeniranje, Pd(II)-katalizirana alkilacija i Ln(III)-katalizirana sililcijanacija.]]></summary_hr><summary_en><![CDATA[This project aims at the development of chiral transition metal catalysts with particular emphasis on inspiration taken from nature. A beta-turn structure is proposed as key feature of chiral catalysts that resemble artificial enzymes with a minimal but functional outer-coordination sphere. These minimal artificial enzymes could find applications in asymmetric synthesis of drugs or drug intermediates produced by pharmaceutical industry.In asymmetric catalysis it is well established that the chiral information should be incorporated as close as possible to the coordination sphere of the catalytic metal. We challenge this important principle and use a catalytic metal center that is only prochiral. The chirality is transmitted by &#39;&#39;backdoor induction&#39;&#39; via hydrogen bonding of distant pendant amino acids that represent the outer-coordination sphere. Preliminary results provide a proof of concept and strongly indicate that simple amino acid bioconjugates of monodentate triphenylphosphane ligands can form supramolecular L2M complexes with Rh(I) that selectively catalyze a model asymmetric hydrogenation reaction with major impact of the distant amino acid sequence on selectivity [Kirin and Kokan, RSC Adv. 2012, Eur. J. Org. Chem. 2013 and Organometallics 2014; ee’s up to 84 %].Within this project, a significant extension is proposed including (i) the use of new ligand bioconjugates with phosphorous or nitrogen donor atoms, (ii) the use of new substrates and (iii) the use of other transition metals for different asymmetric reactions, namely Ru(II)-catalyzed hydrogenation, Pd(II)-catalyzed alkylation and Ln(III) catalyzed silylcyanation.]]></summary_en></project><project>
<id>3090</id><title_hr><![CDATA[Optimizacija parametarski ovisnih mehaničkih sustava]]></title_hr><title_en><![CDATA[Optimization of parameter dependent mechanical systems]]></title_en><user_id>935</user_id><user_firstLast_name>Ninoslav Truhar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-9540</code><acronim><![CDATA[OptPDMechSys]]></acronim><duration>01.07.2015 - 30.06.2019</duration><status>Završio</status><financ_value>111.149,14 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Fakultet primijenjene matematike i informatike]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, School of Applied Mathematics and Informatics]]></institution_en><team_members_id>838, 4088, 4113, 883, 844, 4596, 25434, </team_members_id><team_members_names><![CDATA[Ivana Kuzmanović, Nevena Jakovčević Stor, Ivan Slapničar, Suzana Miodragović, Zoran Tomljanović, Peter Benner, Istkhar Ali, ]]></team_members_names><keywords_hr><![CDATA[veliki parametarski ovisni mehanički sustavi, nelinearni svojstveni problemi, optimizacija prigušenja, optimalno upravljanje, matrične jednadžbe]]></keywords_hr><keywords_en><![CDATA[ large-scaled parameter dependent mechanical systems,  nonlinear eigenvalue problem, damping optimization, optimal control, matrix equations]]></keywords_en><summary_hr><![CDATA[Ovaj je projekt posvećen proučavanju mehaničkih sustava drugog reda opisnih sustavom običnih diferencijalnih jednadžbi čije su matrice velikih dimenzija, ovisne o jednom ili više realnih parametara. Glavnina istraživanja bit će usmjerena na: optimizaciju aktivnog i pasivnog prigušenja, optimalno upravljanje parametarski ovisnim mehaničkim sustavima sa i bez vanjske sile; opisivanje svojstava svojstvenih vrijednosti i svojstvenih vektora parametarski ovisnog pripadnog kvadratnog odnosno nelinearnog problema.Za problem optimizacije aktivnog i pasivnog prigušenja mehaničkih sustava sa i bez vanjske sile, razvit ćemo opći teorijski okvir, i konstruirati adekvatne numeričke algoritme. Ta će teorijska razmatranja biti vezana za optimizaciju raznih parametara prigušenja vezanih uz nekoliko različitih optimizacijskih kriterija. Nadalje, u okviru navedenih problema rješavat ćemo mnoge numerički zahtjevne probleme: problem mješovite cjelobrojne nelinearne optimizacije, efikasno rješavanje velikih matričnih jednadžbi (Lyapunov, Sylvester, Riccati), poboljšanje optimizacijskih algoritama redukcijom modela. Takodjer ćemo razmatrati kako teorijski tako i numerički aspekt problema optimizacije semi-aktivnog prigušenja te optimalnog upravljanja s aspekta različitih kriterija.U okviru problema opisivanja ponašanja svojstvenih vrijednosti i svojstvenih vektora parametarski ovisnog kvadratnog problema, razvit ćemo perturbacijsku teoriju za pripadni kvadratni problem, pri čemu ćemo posebno proučavati slučaj kad je pripadni linearizirani par  dijagonalizabilan, a posebno kada je par definitan. Za oba slučaja razvit ćemo pripadne perturbacijske teorije apsolutnog i relativnog tipa.Navedeni problemi su povezani tako da će nam uvid u ponašanje svojsvenih vrijednosti i pripadnih vektora omogućiti bolje razumjevanje djelovanja prigušenja ili drugih dijelova mehaničkih sustava i obratno. ]]></summary_hr><summary_en><![CDATA[This project is devoted to the second order mechanical systems described by a system of differential equations, whose coefficient matrices are large-scaled and dependent on one or more real parameters.The majority of the research within this project will be focused on: optimization of active and passive damping and optimal control of parameter dependent mechanical systems with and without external force; describing the properties of eigenvalues and eigenvectors of the corresponding parameter-dependent quadratic or nonlinear problem.Within the problem of active and passive damping optimization and optimal control of parameter dependent mechanical systems with and without external force, we will develop a general theoretical framework. These theoretical considerations will be related to the optimization of various damping parameters with respect to a several different optimization criteria. Furthermore, within the stated objectives we will solve many numerical demanding problems: mixed-integer nonlinear optimization problem, efficiently solving of large matrix equations (Lyapunov, Sylvester, Riccati), improving the optimization algorithms by dimension reduction. We will also consider theoretical and numerical aspects of optimization of semi-active damping problem and optimal control based on various criteria.Within the problem of describing the behavior of eigenvalues and eigenvectors of the parameter-dependent nonlinear eigenvalue problems, we will develop perturbation theory for the corresponding quadratic problem separately for cases when the corresponding linearized  pair is diagonalizable or definite. For both cases we will develop perturbation theory of absolute and relative type for the eigenvalues and associated eigenvectors i.e. subspaces.The all mentioned problems are closely related, thus the insight into the behavior of eigenvalues and corresponding eigenvectors will allow better understanding of the behavior of mechanical systems and vice versa.]]></summary_en></project><project>
<id>3101</id><title_hr><![CDATA[Dizajn i sinteza novih dušikovih heterocikličkih fluorofora i fluorescentnih nanomaterijala kao kemijskih senzora za pH i metalne ione]]></title_hr><title_en><![CDATA[Design and Synthesis of Novel Nitrogen-Containing Heterocyclic Fluorophores and Fluorescent Nanomaterials for pH and Metal-Ion Sensing]]></title_en><user_id>227</user_id><user_firstLast_name>Robert Vianello</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-3386</code><acronim><![CDATA[iNFiNiTE–SENS]]></acronim><duration>01.06.2015 - 31.05.2019</duration><status>Završio</status><financ_value>128.475,68 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>854, 3397, 3211, 12962, 2914, 4801, 13134, 2847, 2768, 2769, 4295, </team_members_id><team_members_names><![CDATA[Darko Babić, Ines Despotović, Nena Radić, Ivana Steinberg, Marijana Hranjec, Svjetlana Krištafor, Lidija  Furač, Irena Sović, Maja Aleksić, Nataša Perin, Ema Horak, ]]></team_members_names><keywords_hr><![CDATA[senzori za pH i metalne ione, fluorescentni kemosenzori, fluorofori dobiveni klik-kemijom, sol-gel nanomaterijali, dušikovi heterocikli]]></keywords_hr><keywords_en><![CDATA[metal-ion and pH sensors, fluorescent chemosensors, click-chemistry derived fluorophores, sol-gel nanomaterials, nitrogen heterocycles]]></keywords_en><summary_hr><![CDATA[Ovaj projekt okuplja interdisciplinarni tim znanstvenika s ciljem priprave novih i učinkovitih funkcionalnih materijala za primjenu u području senzora za pH i metalne ione.  Kroz sinergiju u sintetičkim, spektroskopskim i računalnim tehnikama, usmjerit ćemo naša istraživanja na dizajniranje i karakterizaciju čitavog kataloga spojeva sa željenim analitičkim i kemijskim karakteristikama. Eksperimentalni dio posla uključivat će tradicionalne i &#39;&#39;click&#39;&#39;-kemijske strategije za sintezu niza različitih derivata benzimidazola, benzotiazola, 1,2,3-triazola i kumarina, koji će se ugraditi u brojne organske, anorganske i hibridne polimerne matrice u svrhu dobivanja osjetljivih tankih filmova ili polimernih nanočestica. Nakog toga, uz pomoć UV/Vis i fluorescentne spektroskopije, dobiveni materijali bit će ispitani na sposobnost stvaranja kompleksa s metalnim kationima u otopini i čvrstoj fazi te mogućnost formiranja kemijskih senzora. Izbor metalnih analita bit će potaknut njihovom biološkom važnošću ili prisutnošću u okolišu, a uključivat će katione poput Zn2+, Cu2+, Mn2+, Hg2+, Ag+, Cd2+, Fe2+/Fe3+ te Pb2+. Sve faze eksperimentalnog rada nadopunit će se računalnom podrškom za pomoć u tumačenju dobivenih rezultata. To će uključivati izračun konformacijskih, tautomernih i pKa svojstava proučavanih spojeva, predviđanje načina i slobodnih energija vezanja metala te modeliranje promjena u odgovarajućim UV/Vis apsorpcijskim i emisijskim spektrima potaknutim vezanjem metala ili promjenom pH uvjeta otopine. Osim toga, simulacije će biti proširene i razmatranjem različito supstituiranih derivata priređenih organskih molekula kako bi se fino podesila željena svojsta te tako pomoglo ciljanom odabiru budućih koraka u istraživanjima. Sveukupno gledano, predloženi projekt pozicionira ovaj tim za iskorak u području kemijskih senzora uz mogućnost širokog raspona industrijskih aplikacija – od biomedicine do znanosti o okolišu.]]></summary_hr><summary_en><![CDATA[This project brings together an interdisciplinary team of researchers with the aim to prepare novel and efficient functional materials to be used for metal-ion and pH sensing applications. Through a synergy in the synthetic, spectroscopic and computational techniques, we plan to focus our investigations on designing and characterizing a whole catalogue of compounds with desirable analytical and chemical features. Experimental work will involve traditional and &#39;&#39;click-chemistry&#39;&#39; strategies for the synthesis of a number of diverse benzimidazole, benzothiazole, 1,2,3-triazole, and coumarin derivatives, which will be incorporated into a range of organic, inorganic and hybrid polymeric matrices to form sensitive thin films or polymeric nanoparticles. Subsequently, through the UV/Vis and fluorescent spectroscopies, these will be assessed for their abilities to form both solution- and solid-phase complexes with metal cations in order to produce usable chemosensors. The choice of the metal analytes will be prompted by their biological significance or their presence in the environment, comprising cations such as Zn2+, Cu2+, Mn2+, Hg2+, Ag+, Cd2+, Fe2+/Fe3+, and Pb2+. All phases of experimental work will be supplemented with the computational support to aid in the interpretation of results. This will include calculating the conformational, tautomeric and pKa features of investigated systems, predicting the modes and free-energies of metal binding, and modeling the changes in the matching UV-Vis absorption and emission spectra induced by the metal complexation and solution pH variations. In addition, computations will be advanced by considering substituted derivatives of the prepared organic frameworks in order to fine-tune the preferred properties, thus helping in the guided selection of future directions. Overall, the presented research is intended to pose this team for the advancements in the field of chemosensors with the promise of a wide range of industrial applications.]]></summary_en></project><project>
<id>3103</id><title_hr><![CDATA[Sinteza i ciljana primjena metalnih nanočestica]]></title_hr><title_en><![CDATA[Synthesis and Targeted Application of Metallic Nanoparticles]]></title_en><user_id>158</user_id><user_firstLast_name>Iva Rezić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2014-09</proposal_call><code>UIP-2014-09-1534</code><acronim><![CDATA[STARS]]></acronim><duration>01.09.2015 - 31.12.2018</duration><status>Prekinut</status><financ_value>112.411,57 eur</financ_value><scie_area_hr>Tehničke znanosti, Biotehničke znanosti, Prirodne znanosti, </scie_area_hr><scie_area_en>Technological sciences, Biotechnical sciences, Natural sciences, </scie_area_en><scie_field_hr>Kemijsko inženjerstvo, Kemija, Tekstilna tehnologija, Biotehnologija, </scie_field_hr><scie_field_en>Chemical engineering, Chemistry, Textile technology, Biotechnology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Tekstilno-tehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Textile Technology]]></institution_en><team_members_id>351, 2958, 12569, 12361, 602, 517, 1048, </team_members_id><team_members_names><![CDATA[Ana Vrsalović Presečki, Maja Somogyi Škoc, Martina Marchetti-Deschmann, Kristina Šimić, Tatjana Haramina, DAMIR OROS, Roland Ludwig, ]]></team_members_names><keywords_hr><![CDATA[nanočestice, enzimi, polimeri, sol-gel proces, GEMMA, PDMA, GF-AAS, LC-MS/MS]]></keywords_hr><keywords_en><![CDATA[nanoparticles, enzymes, polymers, sol-gel process, GEMMA, PDMA, GF-AAS, LC-MS/MS]]></keywords_en><summary_hr><![CDATA[Glavni cilj projekta uspostava je interdisciplinarne međunarodne istraživačke skupine koja će sintetizirati nove metalne nanočestice pomoću ekološki prihvatljivih enzimski kataliziranih reakcija, te ih zatim nanositi na razne polimerne materijale. Metalne nanočestice imaju odlična nova elektronička, optička, magnetska, medicinska, katalitička i mehanička svojstva zahvaljujući specifičnoj površini koja izrazito ovisi o njihovoj veličini, strukturi i obliku. Predviđa se kako će globalna potražnja za nanočesticama metala i metalnih oksida porasti sa 270 tona u 2012. godini na 1700 tona u 2020. godini. Mi ćemo izolirati i primijeniti pet različitih enzima kako bi sintetizirali metalne nanočestice, odredili kinetiku i mehanizme provedenih reakcija, te zatim karakterizirali produkte reakcije uporabom “beyond-state-of-the-art“ instrumentalnih metoda (GEMMA, PDMA, MALDI-TOF-MS/MS i drugih tehnika). Provedba ovog projekta pomoći će pri osnivanju međunarodne istraživačke grupe koja će obuhvatiti teme iz područja nanotehnologije,  znanosti o materijalima, analitike i bioanalitike, a također će povećati istraživački potencijal mladih istraživača nabavkom znanstvene opreme koja je nužna za provođenje istraživanja vezanog uz sintezu i ciljanu primjenu metalnih nanočestica. Nakon nanošenja pojedinih ciljanih nanočestica na polimere, planiramo razviti nove materijale s namjenskom primjenom u ambalaži prehrambenih proizvoda i geotekstilija. Stoga će ovaj projekt podržati razvoj hrvatske prehrambene i tekstilne industrije. Nadalje, projekt će potaknuti interdisciplinarno istraživanje te omogućiti transfer znanja među istraživačkim grupama u Republici Hrvatskoj, kao i pružiti mogućnost transfera znanja studentima poslijedoktorskih, doktorskih i diplomskih studija koji će biti uključeni u projekt. Valja napomenuti kako će ovaj projekt ojačati i suradnju sa znanstvenicima europskih sveučilišta, te time poduprijeti integraciju hrvatskih znanstvenika u europski istraživački okvir.]]></summary_hr><summary_en><![CDATA[The main objective of this project is to establish international interdisciplinary research group that will synthesize new metal nanoparticles by environmental friendly enzymatic reactions and apply them on different polymer materials. Metal nanoparticles have novel electronic, optical, magnetic, medical, catalytic and mechanical properties owing to their high surface to volume ratio and the quantum size effect, which depend greatly on their size, structure and shape. Therefore a conservative estimation of the world market predicts the global consumption of metal oxide nanoparticles to rise from 270 tons in 2012 to 1700 tons by 2020. We will isolate and use five different enzymes to synthesize metallic nanoparticles, reveal the kinetics and mechanism of reactions, and characterize the products by using “beyond-state-of-the-art” instrumental methods (such as GEMMA, PDMA and MALDI-TOF-MS/MS). Implementation of this project will help establishing new interdisciplinary research group targeting problems in the fields of nanotechnology, material science and bio/analytical chemistry, as well as enhance the independent research leadership of the principal investigator by installing the scientific infrastructure necessary for research on the synthesis and targeted application of metal nanoparticles. By deposition of targeted nanoparticles on polymers, we will create new materials foreseen as food packaging materials and geotextiles. This will support the development of the Croatia’s food and textile industries. Moreover, the project will initiate interdisciplinary research with the transfer of knowledge among research groups, as well as provide the opportunity to transfer knowledge to postdoctoral, doctoral and diploma students working on this project. In addition, this project will strengthen international collaborations with scientists from other European universities, and by this support the integration of the Croatian science within the European research framework. ]]></summary_en></project><project>
<id>3108</id><title_hr><![CDATA[Uporaba metoda i otvorenih tehnologija dubinske analize podataka za unaprijeđenje infrastrukture elektroničkog učenja]]></title_hr><title_en><![CDATA[Leveraging data mining methods  and open technologies for enhancement of the e-learning infrastructure]]></title_en><user_id>3529</user_id><user_firstLast_name>Damir Pintar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2014-09</proposal_call><code>UIP-2014-09-2051</code><acronim><![CDATA[eduMINE]]></acronim><duration>01.10.2015 - 31.12.2018</duration><status>Završio</status><financ_value>57.965,36 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>3645, 3641, 5132, 3643, 7042, 17798, </team_members_id><team_members_names><![CDATA[Mihaela Vranić, Luka Humski, Zoran Skočir, Frano Škopljanac-Mačina, Boris Vrdoljak, Marina Ptiček, ]]></team_members_names><keywords_hr><![CDATA[rudarenje podataka, elektroničko učenje, analiza podataka, konceptualne mape,  uslužna orijentirast, modeliranje ponašanja]]></keywords_hr><keywords_en><![CDATA[educational data mining,  e-learning, data analysis, , concept maps, service-oriented, behavior modelling]]></keywords_en><summary_hr><![CDATA[Informacijski sustavi u školama i sveučilištima stvaraju ogromne količine podataka koji, nakon svoje incijalne uporabe, se najčešće arhiviraju te koriste isključivo u agregiranom obliku za potrebe sažetog izvještavanja. Naš tim predlaže stvaranje rješenja eduMINE, u kojem bi se kroz primjenu metoda rudarenja podataka i pripadnih algoritama uz pomoć navedenih podataka otkrili potencijalno interesantni uzorci i nove informacije, prateći najnovija znanstvena dostignuća iz znanstvenog polja EDM (Educational Data Mining). Rezultati ispita, prilagođene konceptualne mape i ostali podaci služili bi kao ulaz u proces rudarenja. Rezultati metoda bili bi integrirani u trenutni sustav potpore elektroničkom učenju s namjrom da pruži korisne povratne informacije nastavnom osoblju, kako vezano uz stvaranje i prilagodbu nastavnih materijala tako i kroz stvaranje balansiranih, objektivnih ispita. Rezultati rudarenja također bi trebali pomoći u ranoj identifikaciji studenata koji su u opasnosti pada kolegija.Bitno je naglastiti da svi članovi ovog projekta imaju široko iskustvo sa metodama analize podataka te da su objavili niz članaka vezanih uz algoritme i mjere korištene u polju rudarenja podataka. Dodatno, tim ima višegodišnje iskustvo u sveučilišnoj edukaciji, uglavnom na velikim predmetima prve i druge godine sveučilišnog obrazovanja koje godišnje pohađa preko 600 studenata. Smatramo da uz dovoljno vremena i resursa možemo ponuditi rješenje koje će dodatno povisiti kvalitetu obrazovanja i biti primjenjivi ne samo u okruženju u kojem djelujemo već u bilo kojoj sličnoj obrazovnoj okolini.]]></summary_hr><summary_en><![CDATA[Information systems in schools and universities generate large amounts of data. This data, after its initial usage, is most commonly archived and used only in aggregate forms for condensed reports. We propose a pilot project called eduMINE, in which we will apply data mining methods and algorithms on this data to discover potentially interesting patterns and other information hidden within, following recent reasearch accomplishments from the field of EDM (Educational Data Mining). Test scores, customized concept maps and other available data will serve as input for the data mining process. Results of these methods will then be integrated with the existing e-learning support information system with the intention to provide a useful feedback to the lecturers, both regarding the course lectures generation and adaptation as well as generation of well balanced and objective tests. Results should also aim to help with early identification of students who are in danger of failing a course.It is important to emphasize that all team members of this research proposal have extensive experience in methods of data analysis and have developed and published research papers describing new algorithms and measures used for certain data mining approaches. Furthermore, the team has plenty of direct experience in education, most of it concerning large first and second-year college-level courses taken by over 600 students yearly. We are confident that given enough time and resources we can offer solutions which would result in further enhance the quality of education and be applicable not just in the specific domain we are directly involved in, but in any similar education environment.]]></summary_en></project><project>
<id>3121</id><title_hr><![CDATA[Hrvatsko longitudinalno istraživanje dobrobiti]]></title_hr><title_en><![CDATA[Croatian Longitudinal Study on Well-Being]]></title_en><user_id>67</user_id><user_firstLast_name>Ljiljana Kaliterna Lipovčan</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-4398</code><acronim><![CDATA[CRO-WELL]]></acronim><duration>01.10.2015 - 30.09.2019</duration><status>Završio</status><financ_value>60.003,98 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Psihologija, </scie_field_hr><scie_field_en>Psychology, </scie_field_en><institution_hr><![CDATA[Institut društvenih znanosti Ivo Pilar]]></institution_hr><institution_en><![CDATA[Institute of Social Sciences Ivo Pilar in Zagreb]]></institution_en><team_members_id>133, 5219, 3880, 2727, 190, 6242, 5522, 1255, 23199, </team_members_id><team_members_names><![CDATA[Andreja Brajša-Žganec, Tihana Brkljačić, Renata Franc, Ines Sučić, Ivan Balabanić, Maja  Tadić, Renata Glavak Tkalić, Zvjezdana Prizmić-Larsen, Lana Lučić, ]]></team_members_names><keywords_hr><![CDATA[dobrobit, životni događaji, regulacija emocija, ličnost, longitudinalno istraživanje]]></keywords_hr><keywords_en><![CDATA[well-being, life events, affect regulation, personality, longitudinal study]]></keywords_en><summary_hr><![CDATA[Namjera nam je pokrenuti on-line longitudinalno istraživanje dobrobiti. Ovaj projekt ima dva cilja. Prvi cilj je provjeriti stupanj u kojem se dobrobit mijenja tijekom vremena i jesu li obrasci tih promjena različiti za ljudie različitih osobina. Drugi cilj je ispitati može li se dobrobit smatrati ne samo pokazateljem dobrog života, nego i nužnim dijelom povoljnih ishoda i pozitivnih životnih događaja, kao što je predloženo u teoriji proširenja i izgradnje pozitivnih emocija. Mi tvrdimo da visoke razine dobrobiti omogućavaju stvaranje kasnijih povoljnih životnih događaja i uvjeta za učinkovite strategije regulacije emocija. Tijekom razdoblja od četiri godine planiramo provesti on-line panel istraživanje u četiri vala. U istraživanju će biti korišten uzorak odraslih internet korisnika u Hrvatskoj. Bit će prikupljeni podaci o socio-demografskim varijablama, osobinama ličnosti, različitim sastavnicima dobrobiti, strategijama regulacije emocija i životnim događajima. U pilot testiranju bit će provedene fokus grupe u svrhu razvoja instrumenata. Kako bi privukli što je moguće više sudionika u istraživanje i smanjili osipanje tijekom provedbe uzastopnih valova istraživanja, puno će truda biti uloženo u promociju i oglašavanje projekta, kao i u informiranje i motiviranje sudionika da nastave sa sudjelovanjem u istraživanju. Praćenjem ljudi kroz duži period moći ćemo bolje objasniti povezanost između dobrobiti i životnih ishoda, kao i promjena u dobrobiti.]]></summary_hr><summary_en><![CDATA[We intend to launch on-line longitudinal research on well-being. The goal of the project is twofold. First, to examine the degree to which well-being fluctuates over time and whether patterns of well-being fluctuations are different for different types of people. Second, we aim to examine whether well-being can be considered not only as an indicator of good life, but also as a precondition of  positive outcomes and favourable life events, as proposed in the broaden-and-build theory of positive emotions. We posit that high levels of well-being enable the creation of later favourable life events and conditions by effective affect regulation strategies. During the four year project period, we plan to conduct on-line four-wave panel survey. Study sample will consist of adult internet users in Croatia. Through the survey, data on socio-demographic variables, personality traits, different components of well-being, affect regulation strategies and life events will be collected. Focus groups will be used as pilot tests to develop instruments. In order to recruit as many respondents as possible and to minimize attrition over the course of the consecutive waves lots of effort will be put into project promotion and advertising, as well as into informing and motivating participants to continue with the research. By following people through longer periods of time we would be able to better explain the relationships between well-being and life outcomes, as well as fluctuations in well-being.]]></summary_en></project><project>
<id>3125</id><title_hr><![CDATA[Univerzalne osobine sustava hladnih bozonskih i fermionskih atoma]]></title_hr><title_en><![CDATA[Universal properties of cold atomic Bose and Fermi systems]]></title_en><user_id>875</user_id><user_firstLast_name>Leandra Vranjes Markic</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-2452</code><acronim><![CDATA[UniCold]]></acronim><duration>15.06.2015 - 14.03.2019</duration><status>Završio</status><financ_value>79.036,43 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Science]]></institution_en><team_members_id>4442, 6261, 4840, 6341, 20888, 18947, 18948, </team_members_id><team_members_names><![CDATA[Petar Stipanović, Robert Zillich, Jordi Boronat Medico, Henry  Glyde, Andrii Gudyma, Krešimir Dželalija, Viktor Cikojević, ]]></team_members_names><keywords_hr><![CDATA[ultrahladni plinovi, kvantni Monte Carlo, univerzalnost, nered, BEC, suprafluidnost, spin-orbit vezanje, kvantna halo stanja]]></keywords_hr><keywords_en><![CDATA[ultracold gases, Quantum Monte Carlo, universality, disorder, BEC, superfluid, spin-orbit coupling, quantum halo state]]></keywords_en><summary_hr><![CDATA[Ultrahladni plinovi nude besprimjerne mogućnosti proučavanja jako koreliranih sustava  i razmatranje izazova u različitim područjima fizike.  Pogodni su zbog podesivosti jačine  interakcija i mogućnosti kontroliranja i  istraživanja utjecaja dimenzionalnosti, neredai kvantne statistike. Omogućavaju eksperimentalno ostvarenje kako tradicionalnih modela fizike kondenzirane materije tako i novih sustava kao što su spin-orbit vezani (SOC) bozoni.Posebno su zanimljive njihove univerzalne osobine, koje omogućavaju uspostavljanje veza između fenomena na različitim skalama energije i duljine. Rezonantni režim s duljinom raspršenja jednakom nulipredstavlja univerzalnu jako interagirajuću unitarnu granicu, gdje su potrebna točna teorijska predviđanja koja uključuju efekte iznad teorije srednjeg polja. Kvantnim Monte Carlo(QMC) metodama moguće je točno riješiti višečestičnu Schrodingerovu jednadžbu za atome, molekule, tekućine, krutine i različite modele. U projektu ćemo dalje razviti metode te ih primijeniti na probleme sustava hladnih bozonskih i fermionskih atoma, s ciljem karakterizacije njihovih univerzalnih osobina. Prvo, proučit ćemo sustave malog broja čestica, fokusirajući se na realistična molekularna kvantna halo stanja, kao što su klasteri helija i alkalijskih atoma. Cilj je utvrditi mogu li se univerzalne relacije skaliranja  između energije i veličine sustava, već utvrđene na primjeru trimera, proširiti na sustave većeg broja čestica, što je važno  i za halo stanja u nuklearnoj fizici. Nadalje će se proučiti utjecaj nereda i dimenzionalnosti na univerzalne osobine bozonskih i bozonsko ferminskih mješavina u zamkama. Posebno zanimljiv je prijelaz između suprafluida i izolatora te lokalizacija suprafluidnosti i Bose-Einsteinove kondenzacije. Naposljetku, QMC metode ćemo dodatno razviti tako da uzimaju u obzir i spinove čestica, što će omogućiti proučavanje univerzalnosti i novih faza SOC plinova.                                                                                                                  ]]></summary_hr><summary_en><![CDATA[Ultracold gases provide unprecedented possibilities to study strongly correlated systems and address challenges indifferent fields of physics. The advantages they provide aretunability of interactions, possibility to control and exploredimensionality effects, disorder and quantum statistics. Theyallow the experimental realisation and study of both traditionalmodels from condensed matter physics and novel systems suchas spin-orbit coupled (SOC) bosons. Especially interesting are their universal properties, which enable establishment of connections betweenphenomena at different energy and length scales. The resonant regimeof zero-scattering length provides a universal strongly interacting unitary limit, where accurate theoretical predictions beyond mean field are necessary.  Quantum Monte Carlo (QMC) methods are able to accurately solve many-bodySchrodinger equation of atoms, molecules, liquids, solidsand different model systems. In the project we&#39;ll further developthe methods and apply them to problems in the field of coldBose and Fermi atoms, with the goal to characterize their universal properties. First, we&#39;ll study few-body systems,focusing on realistic molecular quantum halo states, such ashelium-alkali clusters. The goal is to establish whether universal scaling relations between energy and size, already established for trimers, can be established for clusters with more particles. This would provide benchmarkfor halo states in nuclear physics. Next, the effect of disorder and dimensionality on universal properties of trapped Bose-Bose and Bose-Fermi systems will be studied.Especially interesting is the superfluid-insulator transition and localization ofsuperfluidity and Bose-Einstein condensation. Finally, QMCmethods will be further developed so that spin degree offreedom is explicitly accounted for, which will allow study ofuniversality and novel phases of SOC gases.                                                                      ]]></summary_en></project><project>
<id>3128</id><title_hr><![CDATA[Genomski i glikanski biomarkeri PTSP-a]]></title_hr><title_en><![CDATA[Genomic and glycomic biomarkers for PTSD]]></title_en><user_id>1306</user_id><user_firstLast_name>Nela Pivac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-4289</code><acronim><![CDATA[GlycoGenePTSD]]></acronim><duration>01.10.2015 - 30.09.2019</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, Clinical sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>1059, 1022, 1023, 4477, 4478, </team_members_id><team_members_names><![CDATA[Dubravka Švob Štrac, Gordana Nedić Erjavec, Matea Nikolac Perković, Suzana Uzun, Oliver Kozumplik, ]]></team_members_names><keywords_hr><![CDATA[PTSP, N-glikani, epigenetika, GWAS, genetika]]></keywords_hr><keywords_en><![CDATA[PTSD, N-glycans, epigenetics, GWAS, genetics]]></keywords_en><summary_hr><![CDATA[Napredak u razumijevanju glikanskih funkcija i struktura može ponuditi nove biomarkere PTSP-a. Rezultati GWAS studija kombiniranih s metodama visoke djelotvornosti, kao što su analize fluorescentno obilježenih glikana, pokazali su da su geni B3GAT1, SLC9A9, MGA5, FUT8, FUT3/FUT6 i HNF1A povezani s glikozilacijom u zdravih osoba iz Hrvatske. Određivanje plazmatskih i IgG N-glikana u PTSP-u, dodatno korigiranih za mogući genetski i epigenetski utjecaj, poboljšat će naše razumijevanje biološke osnove PTSP-a. Cilj predloženog projekta je istražiti povezanost između genetskih, epigenetskih i glikomskih mehanizama odgovornih za otpornost ili ranjivost na razvoj PTSP-a nakon izlaganja traumatskom iskustvu/iskustvima.Specifični ciljevi projekta su:1) određivanje N-glikana u plazmi i IgG-u bolesnika s PTSP-om i odgovarajućih kontrolnih ispitanika;2) potvrda specifičnih polimorfizama odabranih gena koji reguliraju glikozilaciju proteina, određenih putem GWAS studija, u bolesnika s PTSP-om i odgovarajućih kontrolnih ispitanika;3) procjena utjecaja epigenetske regulacije i ekspresije gena HNF1A na glikozilaciju proteina u bolesnika s PTSP-om i odgovarajućih kontrolnih ispitanika.Ovakav pristup će ponuditi integraciju i razumijevanje multidimenzionalnih baza podataka i identificirati nove biomarkere PTSP-a, kao i nove mete i nove strategije u prevenciji razvoja PTSP-a nakon izlaganja traumi ili u terapijskoj intervenciji u PTSP-u.]]></summary_hr><summary_en><![CDATA[The advances in understanding of glycans’ function and structure might offer new biomarkers of PTSD. The results from GWAS, combined with high throughput analysis of fluorescently labelled glycans, suggest B3GAT1, SLC9A9, MGA5, FUT8, FUT3/FUT6 and HNF1A genes to be associated with glycosylation in healthy individuals from Croatia. Determination of N-glycans associated with PTSD in plasma and from IgG, additionally corrected for a possible genetic and epigenetic influence, will improve our understanding of the biological underpinnings of PTSD. The proposed project aims to provide an association between genetic, epigenetic and glycomic mechanisms responsible for the resilience or vulnerability to develop PTSD after exposure to a traumatic event(s).The specific aims of the project are:1) determination of plasma and IgG N-glycans in patients with PTSD and in matched control subjects;2) confirmation of the polymorphisms in the specific selected genes which regulate protein glycosilation, determined by GWAS, in patients with PTSD and in matched control subjects; 3) evaluation of the influence of epigenetic regulation and expression of the HNF1A gene on protein glycosylation in patients with PTSD and in matched control subjects.This approach will offer integration and understanding of the multidimensional dataset and identify novel biomarkers of PTSD, as well as new targets and novel strategies to prevent development of PTSD after exposure to a trauma, or for therapeutic intervention in PTSD.]]></summary_en></project><project>
<id>3137</id><title_hr><![CDATA[Adipocitokinima modulirana disfunkcija endotela u podlozi mikrovaskularnih komplikacija šećerne bolesti tipa 1 i tipa 2]]></title_hr><title_en><![CDATA[Relationship between endothelial dysfunction driven by adipocitokines and the development and progression of microvascular complications in patients with type 1 and type 2 diabetes]]></title_en><user_id>12770</user_id><user_firstLast_name>Lea Smirčić Duvnjak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-7459</code><acronim><![CDATA[ADIEDM]]></acronim><duration>16.12.2015 - 15.12.2019</duration><status>Prekinut</status><financ_value>81.677,62 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Clinical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>12904, 12799, 12511, 1288, 13072, 12935, 13091, </team_members_id><team_members_names><![CDATA[Draško Pavlović, Sandra Vučković-Rebrina, Tomislav Bulum, Marijana Vučić Lovrenčić, Vladimir Vuksan, Martina Tomić, Vinko Vidjak, ]]></team_members_names><keywords_hr><![CDATA[adipocitokini, endotelna disfunkcija, mikrovaskularne komplikacije, šećerna bolest  tip 1, šećerna bolest tip 2]]></keywords_hr><keywords_en><![CDATA[adipocitokines, endothelial dysfunction, microvascular complications, diabetes mellitus type 1, diabetes mellitus type 2]]></keywords_en><summary_hr><![CDATA[Značaj šećerne bolesti počiva na pogubnom učinku mikro i makrovaskularnih komplikacija na morbiditet i mortalitet oboljelih. Stoga je njihova prevencija u središtu znanstvenog i stručnog interesa. Metabolički poremećaji u šećernoj bolesti: inzulinska rezistencija, hiperglikemija i dislipidemija uz oksidativni stres i upalu niskog stupnja doprinose endotelnoj disfunkciji i razvoju makrovaskularnih komplikacija. Novije spoznaje ukazuju na moguću ulogu adipocitokina visceralnog masnog tkiva u nastanku mikrovaskularnih komplikacija u šećernoj bolesti. Ispitivanja provedena na staničnim kulturama te eksperimentalnim životinjskim modelima ukazuju na povezanost  adiponektina, leptina, rezistina te dipeptidil peptidaze-4 (DPP4) sa  aktivnošću  endotelne sintetaze dušičnog oksida (eNOS). Pretpostavka ovog istraživanja je da niža plazmatska koncentracija adiponektina, a viša koncentracija leptina, rezistina i serumska aktivnost DPP4  pogoršanjem endotelne funkcije doprinose nastanku i progresiji mikrovaskularnih komplikacija šećerne bolesti.  Ovo prospektivno istraživanje uključit će 400 bolesnika s šećernom bolešću  tipa1 i tipa 2. Istražit će se učinak plazmatske koncentracije adiponektina, leptina, rezistina i serumske aktivnosti DPP4 na parametre endotelne disfunkcije: dušični monoksid (NO), von Wilebrandov faktor (vWF),  indeks reaktivne hiperemije i brzinu širenja pulsnog vala te razvoj i progresiju mikrovaskularnih komplikacija: retinopatije, nefropatije i neuropatije. Rezultati će doprinijeti razjašnjenju složene patogeneze mikrovaskularnih komplikacija u šećernoj bolesti. Moguća identifikacija novih biljega mikrovaskularnih komplikacija unaprijedit će njihovu dijagnozu u osnovnim tipovima šećerne bolesti uz posljedični razvoj individualiziranog pristupa njihovoj prevenciji i liječenju.]]></summary_hr><summary_en><![CDATA[Micro and macrovascular complications are the  leading cause of morbidity and mortality in diabetic patients.  During the last decades attention has been focused  on their early diagnosis and prevention. Diabetes related metabolic abnormalities:  insulin resistance, hyperglycemia and dyslipidemia along with oxidative stress and low- grade inflammation contribute to the development of endothelial dysfunction and macrovascular complications. Recent investigations indicate a potential role of adipocitokines originating from visceral adipose  tissue: adiponectin, leptin, resistin and dipepetidyl peptidase- 4  (DPP-4) activity in the development of microvascular complications in diabetes. The association of  these  adipocitokines with the activity of endothelial synthetase (eNOS) involved into the metabolism of nitric oxide (NO) was documented in animal and cell culture studies. We hypothesize that lower adiponectin and  higher leptin and resistin plasma concentration and DPP-4 activity are associated with the development and progression of diabetic microvascular complications by endothelial function impairment.Four hundred patients with type 1 and type 2 diabetes will be included in this prospective study.  The association between  adiponectin, leptin, resistin plasma concentration,  DPP-4 activity  and  endothelial markers: NO, von Wilebrand factor (vWF),  pulse wave velocity (PWV) and  reactive hyperemia index (RHI) on the development and progression of microvascular complications will be assessed.Our results will provide further insight into the complex pathophysiology of microvascular complications in diabetes. A possible identification of new markers of their development and progression will contribute to improved diagnosis followed by an individualized patients approach.]]></summary_en></project><project>
<id>3139</id><title_hr><![CDATA[Aktivni nadzor bjesnoće u šišmiša-bitan faktor za procjenu buduće prijetnje]]></title_hr><title_en><![CDATA[Active surveillance of rabies in bats - the essential factor for the assessment of the future threat]]></title_en><user_id>2533</user_id><user_firstLast_name>Tomislav Bedeković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2014-09</proposal_call><code>UIP-2014-09-8513</code><acronim><![CDATA[BatsRabTrack]]></acronim><duration>01.04.2016 - 30.06.2019</duration><status>Završio</status><financ_value>114.531,61 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Veterinarska medicina, </scie_field_hr><scie_field_en>Veterinary medicine, </scie_field_en><institution_hr><![CDATA[Hrvatski veterinarski institut]]></institution_hr><institution_en><![CDATA[Croatian Veterinary Institute]]></institution_en><team_members_id>12561, 12614, 12606, 13064, 2543, 2564, </team_members_id><team_members_names><![CDATA[Florence Cliquet, Evelyne Picard-Meyer, Marine Wasniewski, Ivana Šimić, Nina Krešić, Ivana Lojkić, ]]></team_members_names><keywords_hr><![CDATA[šišmiši, bjesnoća, nadzor, prevalencija, procjena rizika ]]></keywords_hr><keywords_en><![CDATA[bats, rabies, surveillance, prevalence, risk assessment]]></keywords_en><summary_hr><![CDATA[Bjesnoća je jedna od najstarijih i najvažnijih zoonoza, s najvišom stopom smrtnosti od svih poznatih uzročnika zaraza, koja i dalje uzrokuje značajna obolijevanja i smrtnost kod ljudi. Rezervoari klasičnog virusa bjesnoće (RABV) genotipa 1 su vrste iz reda Carnivora te Chiroptera (šišmiši) u sjevernoj i južnoj Americi. U Europi su zastupljeni virusi šišmiša iz roda Lyssavirus, a nazivaju se Lyssavirusi europskog šišmiša (EBLV – European Bat Lyssavirus) tipa 1 i 2 (genotip 5 i 6). Ograničeni su na šišmiše kao domaćine, a poznato je da inficiraju ne samo svog primarnog domaćina nego i prenose infekciju na kopnene sisavce, uključujući domaće životinje, divljač i čovjeka. Infekcije šišmiša virusom EBLV u Europi potvrđene su uglavnom u Nizozemskoj, Njemačkoj, Danskoj i Poljskoj. Od 1977. godine prijavljena su četiri smrtna slučaja ljudi oboljelih od EBLV-a. Većina (>95%) virusnih izolata pripada EBLV tipu 1 i uglavnom je vezana uz šišmiše vrste kasni noćnjak (Eptesicus serotinus), dok su EBLV tip 2 vezani uz vrste roda Myotis. Aktivan nadzor šišmiša radi procjene prevalencije EBLV-a provodi se u zapadnoeuropskim državama (Njemačkoj, Velikoj Britaniji, Francuskoj, Nizozemskoj, Belgiji i Španjolskoj); međutim, podaci za Jugoistočnu Europu su ograničeni. Iz tog razloga, rizik od šišmiša kao rezervoara bjesnoće i njihov utjecaj na javno zdravstvo u ovoj regiji, uključujući i Hrvatsku, još su nepoznati. Potvrđeno je da u Hrvatskoj živi ukupno 35 različitih vrsta šišmiša, što je među najvećim obiljem vrsta u Europi. Sve vrste šišmiša za koje je potvrđeno da prenose bjesnoću prisutne su u Hrvatskoj i stoga bi mogle predstavljati i rizik za ljude. Iz tih razloga, predlažemo trogodišnji projekt aktivnog nadzora bjesnoće u šišmiša kako bi procjenili izloženost virusu EBLV i to u ciljanih vrsta šišmiša (Myotis myotis, M. schreibersii, Rhinolophus ferrumequinum i Eptesicus serotinus) iz tri glavne hrvatske biogeografske regije.]]></summary_hr><summary_en><![CDATA[Rabies is an ancient major zoonosis with the highest mortality of any known infectious agent that continues to cause considerable human illness and death. The prototypic classical rabies virus (RABV) of genotype 1 has reservoirs in species of the order Carnivora, and also in Chiroptera (bats) in the Americas. In Europe, two bat lyssaviruses, referred to as European bat lyssaviruses (EBLVs) types 1 and 2 (genotypes 5 and 6), are host restricted to bats, and have been known to infect not only their primary hosts but also to induce spillover infections to terrestrial mammals including domestic livestock, wildlife and man. EBLV infections in bats in Europe have been confirmed mainly in The Netherlands, Germany, Denmark and Poland. Since 1977, four human deaths from EBLVs have been reported. To date, most (>95%) viral isolates have been of EBLV type 1 and are predominantly associated with the serotine bat (Eptesicus serotinus), whereas EBLV type 2 appears to be associated with Myotis species. Active surveillance of bats to assess the prevalence of EBLV has been conducted in Western European countries (Germany, United Kingdom, France, Netherland, Belgium and Spain); however, data for Southeastern Europe are limited. For this reason, the risk of bats as a rabies reservoir and the impacts on public health for this region including Croatia are still unknown. A total of 35 bat species are known to inhabit Croatia, which is among the highest species richness in Europe. All bat species confirmed to carry rabies are present in Croatia, and therefore could represent a human health risk. For these reasons, we propose a three-year active surveillance project to assess the exposure of target bat species (Myotis myotis, M. schreibersii, Rhinolophus ferrumequinum and Eptesicus serotinus) from the three Croatian main biogeographical regions to EBLVs. ]]></summary_en></project><project>
<id>3140</id><title_hr><![CDATA[Programski sustavi u evoluciji: analiza i inovativni pristupi pametnom upravljanju]]></title_hr><title_en><![CDATA[Evolving software systems: anaysis and innovative approaches for smart management]]></title_en><user_id>1409</user_id><user_firstLast_name>Tihana Galinac Grbac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2014-09</proposal_call><code>UIP-2014-09-7945</code><acronim><![CDATA[EVOSOFT]]></acronim><duration>01.07.2015 - 31.10.2018</duration><status>Završio</status><financ_value>78.877,17 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Tehnički fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Engineering]]></institution_en><team_members_id>2658, 5217, 3658, 13494, 1485, 5358, 20529, 21406, 22612, </team_members_id><team_members_names><![CDATA[Goran Mauša, Per Runeson, Fabrizio Montesi, Jean Petric, Ivan Štajduhar, Darko Huljenić, Nikola Tanković, Joao Costa, Ana Vranković, ]]></team_members_names><keywords_hr><![CDATA[evolucija, kompleksni softverski sustavi, pametno upravljanje, distribucije neispravnosti, struktura]]></keywords_hr><keywords_en><![CDATA[evolution, complex software system, smart management, fault distributions, structure]]></keywords_en><summary_hr><![CDATA[Kompleksni programski sustavi koji se evolucijski razvijaju (EVOSOFT) postali su središnji sve većeg broja aplikacija, proizvoda i usluga, a koji su potpora svakodnevnim ljudskim aktivnostima iz svih gospodarskih sektora. Često su to distribuirani sustavi , heterogeni , decentralizirani i međusobno zavisni, koji rade u dinamičnim i nepredvidljivim uvjetima, pa su njihova dostupnost i pouzdanost postale ključna svojstva potrebna za njihov rad i budući razvoj. Novoi još neistraženo područje istraživanja a koje se obrađuje u ovom projektu je razumjeti kako apstraktne programske strukture i lokalna obilježja sustava utječu na distribuciju neispravnosti, a čime se utječe na kritična svojstva sustava, među kojima je dostupnost i pouzdanost te razvijati inovativne pristupe za pametno upravljanje njihovim izvođenjem i evolucijom. Potrebno je za naglasiti da se ovdje suočavamo s potpuno novim pojavama, sličnim ljudskoj evoluciji, ali koje su proizvedene ljudskim intelektom. Temelji i teorije iz drugih disciplina kojima je cilj razumjeti ponašanje kompleksnih sustava, evolucije te ljudsko razmišljanje mogle bi ovdje biti primijenjive. Novi rezultati otvoriti će nove mogućnosti u mnogim znanstvenim područjima, osobito u teoriji kompleksnih sustava i njenih primjena, te tako međudjelovati sa širokim spektrom znanosti, od prirodnih znanosti kao što su to biomedicina pa sve do društvenih znanosti . Industrijsko iskustvo prikupljeno iz empirijskog pristupa programskom inženjerstvu je iznimno važno za daljnji razvoj discipline programskog inženjerstva. Nove teorije ne mogu biti djelotvorne i primjenjive u industriji, bez temeljnog razumijevanja EVOSOFT ponašanja . Glavni cilj ovog projekta je da će ispuniti taj jaz između empirijskih dokaza i teoretskih modela . Kako bi ostvarili taj cilj kombiniramo empirijska i teoretska znanja tako što ćemo:• ponoviti studije i potvrditi empirijske principe i metode i na kojima želimo graditi nove teorije ,• definirati strukturalne ovisnosti za primjenu empirijskih principa, metoda ,• definirati formalne modele i inovativne načine pametnog upravljanja .]]></summary_hr><summary_en><![CDATA[Evolving complex software systems (EVOSOFT) have become a central part of a rapidly growing range of applications, products and services supporting daily human activities from all economic sectors. As they are often distributed, heterogeneous, decentralized and inter-dependent, and operating in dynamic and unpredictable environments, availability and reliability become key properties for its operation and future evolution. The novel and still unexplored area of research addressed in this project is to understand how abstract software structures and local system properties influence fault distributions, thus affecting mission critical system properties, among which availability and reliability and to develop innovative approaches for smart management of their operation and evolution. We are facing with completely new phenomena, similar to human evolution, but produced by human intellect. Foundations and theories from other disciplines aiming to understand complex system behavior, evolution and human reasoning could be applied. New findings would open new opportunities in many scientific fields, especially in complex systems theory and its applications, thus interacting with a wide spectrum of sciences, from natural sciences such as biomedicine to social sciences. Industrial experience gathered by systematic Empirical Software Engineering approach is extremely important for further evolution of software engineering discipline. New theories cannot provide effective means for industry without fundamental understanding of EVOSOFT behavior. The main aim of this project is to fulfill this gap between empirical evidence and theoretical models. In that aim we combined empirical and theoretical skills aiming to: • replicate studies and confirm empirical principles and methods and define a solid base to ground new theories, • define structural dependencies for applicability of empirical principles, methods, • define formal models and innovative approaches for smart management.]]></summary_en></project><project>
<id>3144</id><title_hr><![CDATA[ADAPTIVNA PARAMETRIZACIJA PROMJENJIVIH 3D GEOMETRIJA KOD OPTIMIZACIJE OBLIKA I  BEZMREŽNOG NUMERIČKOG MODELIRANJA]]></title_hr><title_en><![CDATA[ADAPTIVE PARAMETERIZATION OF VARIABLE 3D GEOMETRIES IN SHAPE OPTIMIZATION AND MESHLESS NUMERICAL MODELING]]></title_en><user_id>3851</user_id><user_firstLast_name>Damir Vučina</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-6130</code><acronim><![CDATA[Optimal3D]]></acronim><duration>01.11.2015 - 31.10.2017</duration><status>Završio</status><financ_value>63.706,95 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Temeljne tehničke znanosti, Strojarstvo, </scie_field_hr><scie_field_en>Basic engineering sciences, Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Fakultet elektrotehnike, strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Electrical Engineering, Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>13265, 5150, 4871, 4969, 4873, 4983, 13396, 21278, </team_members_id><team_members_names><![CDATA[Ivo Marinić-Kragić, Željan Lozina, Ivan Tomac, Igor Pehnec, Damir Sedlar, Zoran Milas, Milan Ćurković, Anđela Bartulović, ]]></team_members_names><keywords_hr><![CDATA[Adaptivna parametrizacija oblika, 3D geometrijsko modeliranje, particioniranje po značajkama, optimizacija oblika, bezmrežne metode]]></keywords_hr><keywords_en><![CDATA[Adaptive shape parameterization, 3D geometric modeling, Feature-based partitioning, Shape optimization, Meshless methods]]></keywords_en><summary_hr><![CDATA[Glavni cilj projekta je razvoj numerički efikasnog i dinamički adaptivnog parametarskog zapisa oblika koji donosi povećanu mogućnost modeliranja 3D oblika kako sam po sebi tako i za funkcije oblika u numeričkim metodama.Početni zapis oblika je oblak 3D točaka kakav se dobije sustavom digitalizacije oblika (3D optički sustav za skeniranje visoke razlučivosti). Matematička parametrizacija oblaka točaka zasnivati će se na parametarskim plohama. Integralna kao i po dijelovima povezana parcijalna parametrizacija biti će istražene i uspoređene.Proučavati će se dinamički aspekti parametrizacije. Oblik i posebno topologija objekta će se mijenjati u kvazivremenu simulacije/optimizacije. Za vrijeme procesa, rubovi i vrhovi mogu nestati, a novi se mogu pojaviti, zbog čega parametrizacija treba biti samostalno prilagodljiva na takve promjene.Proučavati će se strategije za redukciju parametarskog skupa nepoznanica na temelju dopuštenih graničnih vrijednosti pogrešaka u području značajki i na temelju ukupne normirane greške. Ove strategije uključuju prilagodljivu preraspodjelu kontrolnih točaka koristeći procedure za detekciju značajki temeljene na omjeru vlastitih vrijednosti i procjeni nagiba i zakrivljenosti. Vrednovati će se prilagodljiva podjela plohe cjelokupnog objekta na dijelove na temelju različitih kriterija.   Proces optimizacije uključuje opsežne izračune odnosno rješavanje problema polja opisanog parcijalnim diferencijalnim jednadžbama. Navedeni aspekti modeliranja oblika također se primjenjuju u bezmrežnim metodama gdje funkcija na domeni određuje numeričko rješenje danog problema polja. Razmotrit će se bezmrežne metode temeljene na &#39;&#39;oblaku&#39;&#39; čvorova koje su značajno manje osjetljive na promjene u konfiguraciji materijala.]]></summary_hr><summary_en><![CDATA[The project focuses on developing numerically efficient and dynamically adaptive parametric representations of shape which autonomously provide increased modeling capacity for the 3D shape itself and for the shape functions in numerical methods. The initial shape iteration will start from 3D point clouds, possibly resulting from shape digitization (existing high-resolution optical scanning system). Mathematical parameterization of the point clouds will be based on parametric surfaces. Integral as well as chained piecewise surfaces will be explored and compared. Dynamic aspects of the parameterizations will be studied. The shape and possibly topology of the object will be changing in simulation/ optimization quasi-time iterations. During the process, edges and peaks may disappear and new ones may arise, whereby the parameterization must be autonomously adaptable to such changes.Strategies for controlled reductions of the parameterization data-sets based on permissible threshold values for peak error and cumulative error norms will also be studied. These strategies will include adaptive re-allocation of the control points using feature recognition procedures (edges, peaks) based on eigenvalue ratios and slope and curvature estimators. Adaptive partitioning of the overall object surface based on different criteria will be evaluated.The optimization process involves extensive field calculations i.e. solving field problems governed by partial differential equations. The above shape modeling aspects also apply with meshless methods where a function across the domain determines the numerical solution of a given field problem. The option applied here will be meshless methods which are based on a nodes “cloud” and are dramatically less sensitive to the change in a material configuration.]]></summary_en></project><project>
<id>3145</id><title_hr><![CDATA[Metabolizam i interakcije biološki aktivnih spojeva i QSAR]]></title_hr><title_en><![CDATA[Metabolism and Interactions of Biologically Active Substances, and QSAR]]></title_en><user_id>3705</user_id><user_firstLast_name>MIRZA BOJIć</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2014-09</proposal_call><code>UIP-2014-09-5704</code><acronim><![CDATA[MAINBASE4QSAR]]></acronim><duration>01.09.2015 - 31.08.2018</duration><status>Završio</status><financ_value>43.134,91 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Farmacija, Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Pharmaceutical sciences, Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Farmaceutsko-biokemijski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Pharmacy and Biochemistry]]></institution_en><team_members_id>4758, 5248, 12989, 12991, 22519, 22518, </team_members_id><team_members_names><![CDATA[Hrvoje Rimac, Zeljko Debeljak, F. Peter Guengerich, Donghak Kim, Andrea Antolić, Goran Benković, ]]></team_members_names><keywords_hr><![CDATA[biološki aktivni spojevi, metabolizam, interakcije, citokromi P450, humani serumski albumin, QSAR]]></keywords_hr><keywords_en><![CDATA[biologically active substances, metabolism, interactions, cytochromes P450, human serum albumin, QSAR]]></keywords_en><summary_hr><![CDATA[U razvijenim su zemljama najučestaliji uzroci smrti krvožilne bolesti. Trombociti su uključeni u hemostazu, trombozu i upalni odgovor, a krvožilne bolesti mogu biti znak njihove patološke aktivacije. U prijašnjim smo radovima pokazali da biološki aktivne tvari, npr. flavonoidi mogu utjecati na agregaciju trombocita pri koncentracijama koje se mogu postići u krvi nakon konzumacije hrane bogatom polifenolima. Također mogu utjecati i na rezultate dijagnostičkih funkcionalnih ispitivanja agregacije trombocita. Daljne studije će se usredotočiti na njihov metabolizam, moguće interakcije i QSAR predviđanje učinka. Ciljevi našeg predloženog projekta su odrediti: 1. Metabolizam flavonoida-ovi spojevi se lako mogu metabolizirati, npr. oksidacijskim i (de)metilacijskim reakcijama; naš je cilj odrediti koji je oblici flavonoida su najzastupljeniji (izvorni spoj ili metaboliti) koristeći humane jetrene mikrosome, rekombinante jetrene citokrome P450 i LC-MS/MS. 2. Interakcije flavonoida-proučavat će se interakcije flavonoida s drugim često korištenim lijekovima na citokrom P450 enzimima (metaboličke interakcije), kao i vezanje flavonoida na humani serumski albumin (distribucijske interakcije). 3. Kvantitativna veza strukture i aktivnosti (QSAR)-na temelju rezultata ispitivanja metaboličkih i distribucijskih ispitivanja odredit će se QSAR modeli koji će dati uvid u strukturne karakteristike flavonoida odgovornih za interakcije i podložnost metabolizmu putem citokroma P450. Uz znanstveno, ovo istraživanje također ima i društveno i ekonomsko opravdanje. Učestalost krvožilnih bolesti u SAD-u u 2010. godini je bila 37%, što je rezultiralo s 444 milijarde dolara u troškovima. U EU se ovom problemu pristupa s posebnom pozornošću jer se u idućih 20 godina očekuje porast troškova od 40% povezanih s liječenjem ovih bolesti. Ta činjenica potiče znanstvenu, kao i farmaceutsku zajednicu da tragaju za boljim i sigurnijim lijekovima, s flavonoidima kao mogućim kandidatima.]]></summary_hr><summary_en><![CDATA[In developed countries, the most common causes of deaths are cardiovascular diseases. Platelets are involved in hemostasis, thrombosis and inflammation, and cardiovascular diseases may be a sign of pathological platelet activation. Prrviously we have shown that biologically active substances, i.e. flavonoids can affect platelet aggregation at concentrations that can be achieved in the blood after consumption of foods rich in polyphenols. Flavonoids may affect the diagnostic tests-functional tests of platelet aggregation. Further studies are to focus on metabolism of flavonoids, possible interactions, and their QSAR prediction. Goals of our proposed project are to determine: 1. Metabolism of flavonoids–these compounds can easily be transformed: oxidations, (de)methylations; thus our objective is to determine which forms are the most prominent ones (parent compound or metabolites) using human liver microsomes, recombinant liver cytochromes P450 and LC-MS/MS. 2. Interactions of flavonoids–interactions of flavonoids with other commonly used drugs on cytochrome P450 enzymes (metabolic interactions) as well as binding of flavonoids to human serum albumin (distribution interaction) will be studied. 3. Quantitative structure activity relationship (QSAR)–based on the results of metabolic and interaction studies, predictive QSAR models will be set giving insight into structural features of flavonoids responsible for interaction and susceptibleness to cytochrome P450 metabolism. In addition to scientific contributions, this research also has social and economic justification. The prevalence of cardiovascular diseases in the USA in 2010 was 37%, resulting in 444 billion USD of costs. In the EU this issue is addressed with special attention as an increase in costs of 40% for the treatment of these diseases is expected in the next 20 years. This drives scientific, as well as pharmaceutical community to search for a better and safer drugs, with flavonoids as prominent candidates.]]></summary_en></project><project>
<id>3148</id><title_hr><![CDATA[Novo poglavlje u procesima prijenosa naboja u vodenim otopinama]]></title_hr><title_en><![CDATA[Charge Transfer Processes in Aqueous Media Revisited]]></title_en><user_id>521</user_id><user_firstLast_name>Ivan Ljubić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-7540</code><acronim><![CDATA[CTPAMR]]></acronim><duration>01.09.2015 - 31.08.2019</duration><status>Završio</status><financ_value>112.416,22 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>3692, 3691, 88, 1205, 13203, 21411, 24440, </team_members_id><team_members_names><![CDATA[Marko Tomislav Cvitaš, Marija Bonifačić, Aleksandar Sabljić, Iva Dzeba, Brunislav Matasović, Ivana Nikšić-Franjić, Igor Sviben, ]]></team_members_names><keywords_hr><![CDATA[Radijacijska kemija, Kvantna kemija, Molekulska dinamika, Reakcijski mehanizam, Kinetika, Vodena otopina, Spregnuti prijenos protona i elektrona ]]></keywords_hr><keywords_en><![CDATA[Radiation chemistry, Quantum chemistry, Molecular dynamics, Reaction Mechanism, Kinetics, Aqueous solution, Proton-coupled electron transfer]]></keywords_en><summary_hr><![CDATA[Procesi prijenosa naboja u vodenom mediju od iznimnog su interesa zbog svoje ključne uloge u biokemiji i dizajnu sustava za pretvorbu energije. Unatoč opsežnim dugogodišnjim istraživanjima, načini prijenosa naboja i njihova ovisnost o reakcijskim uvjetima još su uvijek nedovoljno poznati. Sinergijskom kombinacijom eksperimentalnih i računskih pristupa nadamo se ostvariti značajan napredak u razumijevanju mehanizama i kinetike prijenosa naboja u reakcijama slobodnih radikala u vodenom mediju, posebice spregnutog prijenosa protona i elektrona (PCET). Težište će biti na reakcijama alfa-hidroksialkilnih i alfa-aminoalkilnih radikala s halogeniranim organskim supstratima te ovisnost prinosa dehalogenacije o prisutnosti i svojstvima pufera. U sličnim uvjetima planiramo studirati i reduktivna svojstva atoma vodika, što potencijalno pruža fascinantnu mogućnost istraživanja najfundamentalnijih aspekata PCET procesa. Istraživanja će se provoditi gama-radiolizom puferiranih vodenih otopina i kvantitativnim mjerenjima vrste i prinosa nastalih produkata u kombinaciji s kvantno-kemijskim i dinamičkim računalnim metodama, kako u svrhu racionaliziranja eksperimentalnih rezultata tako i za usmjeravanje eksperimenata. Budući da je PCET u ovim sustavima popraćen lančanom reakcijom koja znatno povećava prinose dehalogenacije, namjeravamo iznaći najpovoljnije uvjete za usmjeravanje reakcije u PCET kanal, posebice u odnosu na kompetitivne kanale radikalske supstitucije i adicije. Uspješno ostvarenje ciljeva projektnog prijedloga bitno će pridonijeti rješavanju središnjeg problema kemije slobodnih radikala u vodenim otopinama, tj. na koji način dizajnirati reakcijske uvjete, primjerice pH te koncentracije reaktanata i pufera, kako bi se radikalska reakcija učinkovito usmjerila prema određenom reakcijskom kanalu i na taj način optimizirao prinos produkata.]]></summary_hr><summary_en><![CDATA[Charge transfer processes in aqueous media are of a huge and ongoing interest due to their vital role in biochemistry and energy conversion applications. Despite extensive body of research invested in these processes, various modes of charge transfer and dependence thereof upon the reaction conditions are still insufficiently understood. By a synergistic combination of experimental and computational approaches, we hope to make major advances in understanding of the mechanisms and kinetics of charge transfer in free radical reactions in aqueous media, particularly of the proton-coupled electron transfer (PCET). Our focus will be on the reactions of the a-hydroxyalkyl and a-aminoalkyl radicals with halogenated organic substrates, and how the product yields of such a radical-induced dehalogenation are influenced by several buffer systems. In the similar context, we also plan to study reductive properties of the hydrogen atom, which offers a fascinating prospect of exploring the PCET process at its most fundamental. The reactions will be incited by the g-radiolysis of buffered aqueous solutions, followed by the detection and quantitative measurement of the products. This will be accompanied by quantum-chemical and molecular dynamical calculations, both to help rationalize the experimental findings and to guide the experiments. Because the PCET in these systems is remarkably accompanied by a chain reaction that greatly enhances the dehalogenation yields, we intend to elucidate the favorable conditions for the PCET to occur, especially as opposed to the rival free radical substitution and addition. A successful accomplishment of the objectives will be instrumental for resolution of the central problem in the aqueous chemistry of free radicals, and that is how to rationally design the specific reaction conditions, e.g. pH, reactant and buffer concentrations, in order to steer a free-radical induced reaction and optimize the yield due to a desired reaction channel.]]></summary_en></project><project>
<id>3149</id><title_hr><![CDATA[Uloga fosfoinozitida u nastanku trombocita]]></title_hr><title_en><![CDATA[The role of phosphoinositides in platelet formation]]></title_en><user_id>35</user_id><user_firstLast_name>Antonija Jurak Begonja</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2014-09</proposal_call><code>UIP-2014-09-2400</code><acronim><![CDATA[MkPI]]></acronim><duration>15.09.2016 - 31.12.2019</duration><status>Završio</status><financ_value>132.627,12 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Fakultet biotehnologije i razvoja lijekova]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Biotechnology and Drug Development]]></institution_en><team_members_id>6883, 13546, 24298, </team_members_id><team_members_names><![CDATA[Hana  Mahmutefendić, Ira Milosevic, Ana Bura, ]]></team_members_names><keywords_hr><![CDATA[megakariociti, trombociti, trombopoeza, endocitoza, fosfoinozitidi]]></keywords_hr><keywords_en><![CDATA[megakaryocytes, platelets, thrombopoiesis, endocytosis, phosphoinositides]]></keywords_en><summary_hr><![CDATA[Trombociti su neophodni za hemostazu te također posreduju u procesima različitih bolesti uključujući upale, metastaze, aterosklerozu. Liječenje leukemija i drugih malignih oboljenja ili transplantacije organa često dovode do smanjenja broja trombocita, te predstavljaju rizik od krvarenja. Trombociti nastaju iz citoplazme megakariocita (MK) u koštanoj srži u procesu trombopoeze. MK prolaze složen proces sazrijevanja koji vodi ka stvaranju dugih, razgranatih citoplazmatskih struktura – protrombocita. Molekularni mehanizmi koji reguliraju ove citoplazmatske promjene MK-a u velikoj mjeri su nepoznati. Naša preliminarna istraživanja pokazuju da određena vrsta fosfoinozitida (PI), fosfatidilinozitol 3-monofosfat (PI3P) ima glavnu ulogu u formiranju protrombocita u primarnim kulturama MK-a. U stanicama PI3P se nalazi u ranim endosomima i sudjeluje u endosomskom prometu. Naša je hipoteza da membranski promet reguliran PI3P-om u endocitnom putu znatno pridonosi biogenezi trombocita. Predloženi projekt istražit će točnu ulogu PI3P u stvaranju protrombocita. Koristit ćemo genetski napravljene  fluorescentne probe, tehniku koja se temelji na proteinskim domenama fuzioniranim s fluorescentnim proteinom eksprimiranim s retrovirusa, kako bi odredili lokalizaciju u stvarnom vremenu različitih PI u MK-ima i protrombocitima. Istražit ćemo kako interferencija PI3P funkcije utječe na sazrijevanje MK te utvrditi je li defekt ograničen na endosomski odjeljak. U svrhu utvrđivanja mehanizma djelovanja PI3P-a koristit ćemo genetski i farmakološki pristup kako bi ispitali je li progresija ranih u kasne endosome nužna za stvaranje trombocita. Osim toga, identificirat ćemo proteine koji vežu PI3P regulirajući endosomsku dinamiku važnu za stvaranje protrombocita. Ovo će istraživanje doprinijeti našem razumijevanju osnovnih molekularnih procesa trombopoeze koji bi mogli doprinijeti novim terapijskim strategijama u liječenju trombocitopenije.]]></summary_hr><summary_en><![CDATA[Platelets are essential for hemostasis and they also mediate diverse disease processes including inflammation, metastasis, atherosclerosis. Cancer and leukemia treatments or organ transplants often lead to reduced platelet numbers, putting patients at risk of bleedings. Platelets derive from cytoplasm of megakaryocytes (MKs) in the bone marrow in a process called thrombopoiesis. MKs undergo complex maturation process that leads towards extension of long, branched cytoplasmic structures called proplatelets that eventually release platelets. Molecular mechanisms that govern these elaborate cytoplasmic changes of MKs remain largely unknown. Based on primary MKs our preliminary studies show that one type of phosphoinositides (PIs), phosphatidylinositol 3-monophosphate (PI3P) has a major role in proplatelet formation. PI3P is concentrated in early endosomes and is involved in endosomal trafficking. Our hypothesis is that PI3P regulation of membrane traffic in the endocytic pathway contributes significantly to platelet biogenesis. This proposed project will reveal the exact role of PI3P in proplatelet formation. We will use genetically engineered fluorescent probes, a technique based on protein domains fused with fluorescent protein expressed from retroviruses, to define spatial and temporal localization of different PIs in MKs and proplatelets. We will investigate if interference of PI3P function affects MK maturation and examine if defect is confined to endosomal compartment. To determine mechanism of PI3P action we will use genetic and pharmacologic approaches to examine if progression of early to late endosomes is needed for platelet genesis. In addition, we will identify proteins  that act in concert with PI3P to regulate endosomal dynamics important for proplatelet formation. These studies will contribute to our understanding of basic molecular processes underlying thrombopoieses and might lead towards novel therapeutic strategies in treatment of thrombocytopenia.]]></summary_en></project><project>
<id>3156</id><title_hr><![CDATA[Heuristička optimizacija u kriptologiji]]></title_hr><title_en><![CDATA[Heuristic optimization in cryptology]]></title_en><user_id>6984</user_id><user_firstLast_name>Domagoj Jakobović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-4882</code><acronim><![CDATA[EvoCrypt]]></acronim><duration>01.09.2015 - 31.08.2018</duration><status>Završio</status><financ_value>71.404,87 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>12866, 13359, 13035, 13300, 13522, 13499, </team_members_id><team_members_names><![CDATA[Marin Golub, Nele Mentens, Ante Đerek, Stjepan Picek, Lejla Batina, Danko Ivošević, ]]></team_members_names><keywords_hr><![CDATA[heuristička optimizacija, evolucijski algoritmi, kriptografija, kriptoanaliza, sklopovska izvedba]]></keywords_hr><keywords_en><![CDATA[heuristic optimzation, evolutionary computation, cryptography, cryptanalysis, hardware implementation]]></keywords_en><summary_hr><![CDATA[Cilj ovoga projekta je primjena stohastičkih i determinističkih algoritama optimizacije, kao i metoda strojnog učenja, na aktualnim problemima u kriptologiji. U okviru projekta istražit će se učinkovitost optimizacijskih algoritama, s naglaskom na evolucijsko računanje, primijenjenih na probleme oblikovanja nelinearnih elemenata za kriptografske algoritme, kao što su Booleove funkcije i S-kutije. Dio nastojanja bit će posvećen i optimizaciji sklopovske izvedbe tih elemenata, prije svega u kontekstu povećavanja propusnosti. Osim toga, prijedlog razmatra i problem učinkovitog traženja parametara napada umetanjem pogreške. Kako bi rezultati projekta bili dostupni široj zajednici, dodatna namjena projekta je stvaranje odgovarajuće programske potpore i optimizacijskih algoritama u obliku pratećeg skupa programskih alata, kako bi se omogućila primjena rezultata istraživačima u ovome području.]]></summary_hr><summary_en><![CDATA[This proposal aims at successful application of stochastic and deterministic optimization algorithms, as well as methods from the machine learning community, to current problems in cryptology. The project will investigate the efficiency of stochastic optimization algorithms, with evolutionary computation in particular, applied to the problems of creating nonlinear primitives for cryptography, such as Boolean functions and S-boxes. A part of this goal will also be devoted to optimization of hardware implementations of those primitives, primarily in the context of throughput maximization. Additionally, the proposal considers the problem of efficient search for parameters of successful fault analysis. The results of the project would not be easily attainable to the wider community without an appropriate collection of software tools for evaluation of candidate solutions to these problems and appropriate optimization algorithms. The final objective of this project is the creation of an accompanying open-source software tool collection to facilitate usage by researchers in the field.]]></summary_en></project><project>
<id>3170</id><title_hr><![CDATA[Zelena sinteza organopaladijevih foto-osjetljivih spojeva]]></title_hr><title_en><![CDATA[Green Synthesis of Organopalladium Photosensitizers]]></title_en><user_id>112</user_id><user_firstLast_name>Manda Ćurić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-7984</code><acronim><![CDATA[GREENSENS]]></acronim><duration>15.10.2015 - 14.10.2019</duration><status>Završio</status><financ_value>82.819,03 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>1007, 12522, 3414, 3061, 362, 238, </team_members_id><team_members_names><![CDATA[Marina Juribašić Kulcsar, Krunoslav Juraić, Janez Plavec, Ana Budimir, Snježana Kazazić, Tonko Dražić, ]]></team_members_names><keywords_hr><![CDATA[mehanokemija, starenje, aktivacija C-H veze, mehanizam, spektroskopija, neinvazivni kromogeni i fluorogeni kemosenzori  ]]></keywords_hr><keywords_en><![CDATA[mechanochemistry, aging, C-H bond activation, organopalladium, mechanism, spectroscopy, non-invasive chromogenic and fluorogenic chemosensors]]></keywords_en><summary_hr><![CDATA[Zelena kemija je na čelu aktualnih zbivanja raznih istraživačkih područja u kemiji. Jedan od njezinih glavnih ciljeva je razvijanje učinkovitih preparativnih metoda za različite vrste postojećih i novih kemikalija bez korištenja otapala i uz nisku potrošnju energije. Izvedivost ovog temeljnog koncepta zelene kemije bit će pokazana na sintezi organopaladijevih kompleksa te će većina sintetskih koraka u ovom projektu biti provedena reakcijama u čvrstom stanju, upotrebom metoda ubrzanog starenja i mehanokemije. Prvu mehanosintezu organopaladijevih spojeva aktivacijom C-H veze paladijevim(II) acetatom nedavno je objavila naša grupa. Valja napomenuti da je aktivacija C-H veze od iznimne važnosti u sintetskoj organskoj kemiji. U okviru ovog projekta predlažemo razvijanje i primjenu metoda u čvrstom stanju za sintezu niza ciklopaladiranih aromatskih azo spojeva. Interes za organopalladijeve komplekse s konjugiranim C=C and N=N vezama proizlazi iz njihove jake apsorpcije i emisije svijetla u području niskih energija što ih kvalificira kao dobre kandidate za biomolekulske obilježivače. U tom pogledu, njihov afinitet prema ciljanim amino kiselinama, kratkim peptidima i nukleobazama istražit će se UV-vis and fluorescentnom spektroskopijom. Shodno navedenom, dodatna korist od predloženog projekta bit će niz novih kromogenih i fluorogenih kemosenzora.Struktura produkata u čvrstom stanju odredit će se rendgenskom difrakcijom, NMR, Raman i IR spektroskopijama. Mehanizam ciklopaladacije u čvrstom stanju istražit će se u realnom vremenu in situ praćenjem reakcija Raman spektroskopijom, te u otopini UV-vis i NMR spektroskopijama uz ESI spektrometriju masa. Optička svojstva kompleksa u čvrstom stanju i otopini odredit će se UV-vis and fluoroscentnom spektroskopijom. Eksperimentalni rezultati racionalizirat će se teorijskim istraživanjima da bi se objasnila izomerija kompleksa, priroda njihovih elektronskih prijelaza te da bi se dobila dodatna potvrda za mehanizam ciklopaladacije.]]></summary_hr><summary_en><![CDATA[Green chemistry is at the forefront of current developments of various research areas in chemistry. One of its major objectives is to develop efficient solvent-free and low-energy preparative methods for various classes of existing and new chemicals. The feasibility of this green-chemistry concept will be demonstrated on the synthesis of organopalladium complexes and the majority of synthetic steps in this project will be performed in the solid state by methods of accelerated aging and mechanochemistry. The first mechanosynthesis of organopalladium compounds via C-H bond activation, which is of exceptional importance in organic synthesis, by palladium(II) acetate has been recently reported by our group.Within this project we propose to develop and implement the solid-state methods for the synthesis of a series of cyclopalladated aromatic azo compounds. Interest in such complexes with conjugated C=C and N=N bonds arises from their strong absorption and emission in the low energy region, which qualifies them as good candidates for the biomolecular labels. In this regard, their affinity to target amino acids, short peptides and nucleobases will be studied by UV-vis and fluorescence spectroscopies. Consequently, an additional benefit of this project will be a series of new chromogenic and fluorogenic chemosensors.The solid-state structures of the products will be determined by X-ray diffraction, NMR, Raman and IR spectroscopies. The cyclopalladation mechanism in the solid state will be studied by in situ monitoring of the reactions using Raman spectroscopy, and in the solution by UV-vis and NMR spectroscopies along with the ESI mass spectrometry. The optical characteristics of complexes will be evaluated by UV-vis and fluorescence spectroscopies. The experimental results will be rationalized by theoretical studies in order to explain isomerism of complexes, the nature of their electronic transitions and to obtain additional support for the cyclopalladation mechanism.]]></summary_en></project><project>
<id>3172</id><title_hr><![CDATA[Fiziološki i stereokemijski važni kompleksi bakra(II) s aminokiselinama: molekulsko modeliranje kombinirano s eksperimentalnim istraživanjima]]></title_hr><title_en><![CDATA[Combined molecular modelling and experimental studies of physiologically and stereochemically important copper(II) amino acid complexes]]></title_en><user_id>11255</user_id><user_firstLast_name>Jasmina Sabolović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-3500</code><acronim><![CDATA[CopperAminoAcidates]]></acronim><duration>01.09.2015 - 28.01.2021</duration><status>Završio</status><financ_value>59.724,73 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, Fizika, </scie_field_hr><scie_field_en>Chemistry, Physics, </scie_field_en><institution_hr><![CDATA[Institut za medicinska istraživanja i medicinu rada]]></institution_hr><institution_en><![CDATA[Institute for Medical Research and Occupational Health]]></institution_en><team_members_id>11285, 12798, 1141, 13157, 21234, </team_members_id><team_members_names><![CDATA[Marijana Marković, Michael Ramek, Draginja Mrvoš-Sermek, Gábor Szalontai, Jelena Budimčić, ]]></team_members_names><keywords_hr><![CDATA[bakar, aminokiseline, molekulsko modeliranje, DFT, MM, MD, rendgenska strukturna analiza, NMR čvrstog stanja, cis-trans izomerija, fiziološki spojevi]]></keywords_hr><keywords_en><![CDATA[copper, amino acids, molecular modelling, DFT, MM, MD, X-ray structure analysis, solid-state NMR, cis-trans isomerism, physiological compounds]]></keywords_en><summary_hr><![CDATA[Strukturna istraživanja kompleksa bis(amino acidato)bakra(II), Cu(aa)2, intenzivnije započeta prije oko 45 godina još traju jer su motivirana činjenicama da su to (1) biološki važni spojevi budući da sudjeluju u skladištenju i prijenosu bakra do mjesta u organizmu gdje u optimalnim koncentracijama taj esencijalan element ima važne fiziološke uloge, (2) modelni spojevi za vezivna mjesta za bakar u metaloproteinima, (3) stereokemijski zanimljivi spojevi. Unatoč intenzivnim eksperimentalnim istraživanjima fizioloških Cu(aa)2 posljednjih 40 godina, njihova kompletna geometrija u otopinama uglavnom je nepoznata. Naše je istraživanje bis(L-histidinato)bakra(II) primjenom teorije funkcionala gustoće (Density Functional Theory, DFT) prvo razjasnilo strukturu tog fiziološkog spoja u vodenoj otopini pri fiziološkim uvjetima (Eur J Inorg Chem 2014: 198). Nastavljajući se na naša prethodna istraživanja, glavni je cilj projekta dobiti nove rezultate o fizikalno-kemijskim svojstvima (strukture, energije, vibracije, cis-trans izomerija, konformacijske promjene) u vakuumu, vodenoj otopini i kristalnom okruženju izabranih Cu(aa)2 zbog njihove biološke važnosti i stereokemijske raznolikosti primjenom metoda molekulskog modeliranja (DFT, molekulska mehanika, molekulska dinamika) i eksperimentalnih metoda (rendgenska strukturna analiza, spektroskopija NMR čvrstog stanja). Očekujemo da ćemo kombiniranjem tim metoda pridonijeti rješavanju još uvijek neriješenih pitanja (1) točne geometrije u otopini i čvrstom stanju, (2) procesa na molekulskoj razini. Budući da je interes za istraživanje bakrovih kompleksa kao antiproliferacijskih spojeva znatno porastao u posljednjih nekoliko godina, a detaljna fizikalno-kemijska karakterizacija je prvi nužan korak u istraživanju, realno se očekuje da će novi rezultati pridonijeti otkrivanju novih lijekova. Rezultati istraživanja će značajno unaprijediti znanstvene spoznaje i primjene u bioanorganskoj kemiji, biofizici, biologiji i medicini.]]></summary_hr><summary_en><![CDATA[The structural studies of bis(amino acidato)copper(II) complexes, Cu(aa)2, which started intensively in the 1960s and continue up to date, have been motivated by the facts that these complexes are (1) biologically important as a part of the accessible physiological pool for transport and storage of an essential element copper, (2) appropriate models for copper-binding sites in metalloproteins, (3) sterochemically interesting compounds. Despite intensive experimental studies of physiological Cu(aa)2 during the last 40 years, their exact structures in solutions generally remain unresolved. Our density functional theory (DFT) study of bis(L-histidinato)copper(II) (Eur J Inorg Chem 2014: 198) is the first that clarified the structure of that physiological compound in aqueous solution at physiological conditions. Based on our previous studies, the main goal of the project is to obtain new results on the physico-chemical properties (structure, energy, vibrations, cis-trans isomerism, conformational changes) in different surroundings (vacuum, aqueous solution, solid state) of selected Cu(aa)2 because of their biological importance and stereochemical diversity by using the molecular modelling (DFT, molecular mechanics, molecular dynamics) and experimental (X-ray diffraction, solid-state NMR) methods. By combining these methods we expect to contribute to solving yet unresolved issues of (1) the exact geometries in solution and solid state, (2) the processes occurring at the molecular level. The new results will contribute to understanding the data required in the discovery of new potential drugs since the detailed physico-chemical characterisation is a necessary first step in the drug development. It is worth mentioning that the interest in copper coordination complex research as antiproliferative agents has markedly increased in the last few years. We expect our results to have an impact on applications in bioinorganic chemistry, biophysics, biology, and medicine. ]]></summary_en></project><project>
<id>3173</id><title_hr><![CDATA[Profesionalne aspiracije prema STEM zanimanjima tijekom osnovne škole: longitudinalno istraživanje odnosa postignuća, vjerovanja o vlastitim kompetencijama i interesa za zanimanja]]></title_hr><title_en><![CDATA[STEM career aspirations during primary schooling: A cohort-sequential longitudinal study of relations between achievement, self-competence beliefs, and career interests]]></title_en><user_id>1355</user_id><user_firstLast_name>Josip Burušić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-9250</code><acronim><![CDATA[JOBSTEM]]></acronim><duration>01.09.2015 - 31.08.2019</duration><status>Završio</status><financ_value>78.200,33 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Psihologija, </scie_field_hr><scie_field_en>Psychology, </scie_field_en><institution_hr><![CDATA[Institut društvenih znanosti Ivo Pilar]]></institution_hr><institution_en><![CDATA[Institute of Social Sciences Ivo Pilar in Zagreb]]></institution_en><team_members_id>6293, 5747, 6505, 13063, 13071, 13079, 3455, 3612, 12977, 12965, 21398, 21321, </team_members_id><team_members_names><![CDATA[Toni Babarović, Marija Šakić Velić, Ivan Dević, Mia Karabegović, Leila Selimbegovic, Dubravka Glasnović Gracin, Ina Reić Ercegovac, Tomislav Jagušt, Predrag Pale, Juraj Petrović, Mirta Blažev, Mara Šimunović, ]]></team_members_names><keywords_hr><![CDATA[STEM područje, odabir zanimanja, školska postignuća, pojam o sebi, longitudinalna istraživanja, učinci intervencija]]></keywords_hr><keywords_en><![CDATA[STEM, vocational interest, school achievement, self-concept, self-competence beliefs, longitudinal studies, effectiveness of interventions]]></keywords_en><summary_hr><![CDATA[U globaliziranom, brzo mijenjajućem svijetu, pitanja obrazovnog postignuća i aspiracija mladih prema pojedinim zanimanjima od izuzetnog su značaja. To se posebno odnosi na zanimanja u području znanosti, tehnologije, inženjerstva i matematike (STEM), tehnološki sofisticiranim i inovativnim zanimanjima važnim za društveni razvoj. Od devedesetih na ovamo naklonost mladih upravo za takva zanimanja stalno opada. Istraživači, nositelji politika i institucije poput EU suočeni su s jasnim podacima o evidentnom nedostatku studenata u STEM programima te nedostatku pojedinih STEM stručnjaka.Predloženi projekt temelji se na suvremenim teorijama akademskog postignuća, vjerovanja o vlastitoj kompetenciji u akademskoj domeni i interesa za zanimanja te je strukturiran oko tri glavna istraživačka cilja: (i) ispitati kako se kod učenika opći i specifični interesi za STEM zanimanja stvaraju te mijenjaju li se tijekom vremena; (ii) ispitati odnos školskog postignuća učenika i vjerovanja o vlastitoj kompetenciji s općim i specifičnim interesima za STEM zanimanja, te testirati da li se obrazac tih odnosa mijenja tijekom osnovnoškolskog obrazovanja; (iii) ispitati kako obitelji i spol/rod oblikuju opće i specifične interese učenika vezane uz STEM karijere.Projekt se temelji na longitudinalno-sekvencijalnom istraživačkom nacrtu, složenom metodološkom okviru koji dozvoljava sagledavanje ovakvih istraživačkih pitanja. Ukupno će biti praćeno 1920 učenika osnovnih škola i njihovih roditelja/staratelja, podijeljenih u tri dobne kohorte, koje će se longitudinalno ispitivati kroz tri vala mjerenja. Dodatni je cilj projekta implementirati STEM intervencijski program u osnovne škole te sagledati njegove učinke u kontekstu STEM zanimanja, gdje će se koristiti esperimentalni nacrt s testiranjem prije i nakon tretmana u dvije skupine. Očekujemo da će sve poduzete aktivosti povećati sadašnja znanja, biti poticajne drugim istraživačima, a stečeno znanje korisno učenicima, učiteljima i donositeljima odluka.]]></summary_hr><summary_en><![CDATA[In the globalized and rapidly changing world, the issues of young people’s educational achievement and career aspirations are extremely important. These issues are especially relevant in vocations in the fields of Science, Technology, Engineering and Mathematics (STEM), which are technologically sophisticated and important for the development of the society. Since 1990s the interest of youth for these vocations is declining. Researchers, national governments and authorities like EU operate with exact figures which clearly demonstrate a shortage of STEM graduates and a decline in number of STEM experts.  The proposed project is grounded in contemporary theories of academic achievement, self-competence beliefs and vocational interests and it is structured around three main research goals: (i) to examine how students’ general and specific STEM career aspirations are formed and how they change over time; (ii) to examine how students’ academic achievement and self-competence beliefs are related to their general and specific STEM career aspirations and how the pattern of relations among them changes during the course of primary schooling; (iii) to examine how students’ general and specific STEM career aspirations are shaped by their families and gender. The project is based on a longitudinal research design, as a suitable methodological framework for responding to these complex research questions. A total of 1920 primary school students and their parents/guardians will participate in the study. Students will be grouped in three age cohorts, which will be followed longitudinally through three measurement waves. The additional goal of the project is to implement a STEM intervention program in primary schools and evaluate its’ effects by using two-group pre- and post-test randomized experimental design. The project is intended to create new knowledge useful for researchers, students, teachers as well to create knowledge-based implications for relevant stakeholders.]]></summary_en></project><project>
<id>3183</id><title_hr><![CDATA[Kiralnost od akiralnih tekućih kristala]]></title_hr><title_en><![CDATA[Chirality from Achiral Liquid Crystals]]></title_en><user_id>564</user_id><user_firstLast_name>Andreja Lesac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-1525</code><acronim><![CDATA[CALC]]></acronim><duration>01.06.2015 - 31.05.2017</duration><status>Završio</status><financ_value>63.176,06 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, Fizika, </scie_field_hr><scie_field_en>Chemistry, Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>3232, 5194, 184, 3241, 3233, </team_members_id><team_members_names><![CDATA[Irena Dokli, Trpimir Ivšić, Darko Kontrec, Anamarija Knežević, Ana  Mikleušević, ]]></team_members_names><keywords_hr><![CDATA[dimeri, tekući kristali, kiralna samoorganizacija, konformacijska analiza, NMR]]></keywords_hr><keywords_en><![CDATA[dimers, liquid crystals, chiral self-assembly, conformational analysis, NMR]]></keywords_en><summary_hr><![CDATA[Danas su, materijali sa svojstvima tekućih kristala najpoznatiji po svojoj uspješnoj primjeni u industriji zaslona, a ipak pokazuju mnoštvo specifičnih svojstava koje predstavljaju veliki potencijal kako za nova temeljna istraživanja tako i za inovativnu primjenu povrh one u izradi zaslona. Prijedlog projekta se odnosi na nova istraživanja u području tekućih kristala u kojima se proučava stvaranje helikalnih struktura od molekula koje nisu kiralne, a proizlazi iz prethodnih istraživanja koja su pokazala da fleksibilno povezane dimerne molekule mogu pokazivati ovakvo ponašanje. Prema teorijskom modelu ova helikalna molekulska organizacija ne zahtijeva kiralnost molekule, već ju omogućava svinuti oblik molekule. Unatoč velikom broju studiranih dimera, samo kod nekoliko akiralnih dimernih molekula s neparnom poveznicom primjećena je neobična nematička faza s helikalnom molekulskom organizacijom. Obzirom na ograničena saznanja o helikalnoj organizaciji akiralnih molekula predloženi projket nastoji utvrditi odnos strukture i mezogenih svojstava molekule te povećati broj raspoloživih materijala. Rad predviđa sintezu i karakterizaciju mezogenih svojstava niza novih simetričnih dimera s varijacijama na svim relevantnim strukturnim dijelovima kako bi se istražila njihova uloga u molekuskoj organizaciji unutar tekuće-kristalne faze. Konformacijska analiza korištenjem DFT računa pružit će vrijedne informacije o utjecaju geometrije i elektronske strukture na molekulsko pakiranje, a NMR studija odabranih dimera omogučiti će uvid u međumolekulske interakcije unutar faze. Dakle, očekuje se da će kombinacija eksperimentalni, računalnih i spektroskopskih istraživanja pružiti značajne informacije o strukturnim i elektroničkim čimbenicima koji utječu na nastanak i stabilnost helikalne samoorganizacije što proširuje mogućnost za kontroliranu proizvodnju novih materijala za različite primjene npr. generatori male snage, umjetni mišić, itd.]]></summary_hr><summary_en><![CDATA[Nowadays, liquid crystalline materials are best known for their successful implementation in flat panel displays, and yet they exhibit a plethora of peculiar properties that offer enormous potential for fundamental science as well as innovative applications well beyond the displays sphere. The proposal addresses a fast-developing area of liquid crystal science in which bulk, helical arrangements are formed from constituents, which are not themselves chiral. The current proposal arises from previous work in which it was shown that flexibly linked, dimeric molecules may also exhibit this general behaviour. According to the theoretical model, the arrangement does not require molecular chirality, instead it can be facilitated simply by the shape of bent molecules. Among great number of studied dimers, only a few achiral odd-memebered dimeric molecules displayed an unusual nematic phase with helical molecular organization. Such an observation is unprecedented and the current proposal seeks to delineate the central structure/property correlations and expand the number of such materials available. The work proposed herein envisages synthesis and mesomorphic characterisation a range of novel symmetric dimers having modifications on all relevant structural moieties in order to unravel their role in molecular arrangement within the liquid crystalline state. Conformational analysis using DFT calculation will provide information on geometrical and electronic effects influencing molecular packing while NMR investigation of selected neat dimers will enable direct insight into intermolecular interactions within the phase. Thus, combined experimental, computational and spectroscopic studies will provide valuable information on structural and electronic factors influencing formation and stability of helical self-assembly and expands the possibility for controlled fabrication of novel materials for various applications ranging from micropower generators to artificial muscle.]]></summary_en></project><project>
<id>3187</id><title_hr><![CDATA[Dizajniranje mikrostrukture i funkcionalnih svojstava legura s prisjetljivosti oblika na bazi bakra]]></title_hr><title_en><![CDATA[Design of Microstructure and Functional Properties of Cu-based Shape Memory Alloys]]></title_en><user_id>557</user_id><user_firstLast_name>Mirko Gojić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-3405</code><acronim><![CDATA[DMFP-CuSMA]]></acronim><duration>01.07.2015 - 30.06.2019</duration><status>Završio</status><financ_value>111.111,55 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Metalurgija, Kemijsko inženjerstvo, </scie_field_hr><scie_field_en>Metallurgy, Chemical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Metalurški fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Metallurgy]]></institution_en><team_members_id>554, 285, 826, 550, 576, 1156, 2837, 21382, </team_members_id><team_members_names><![CDATA[Stjepan Kožuh, Robert Pezer, Tamara Holjevac Grgurić, Ivana Ivanić, Ladislav Vrsalović, Borut Kosec, Ivan Anžel, Dragan Manasijević, ]]></team_members_names><keywords_hr><![CDATA[Legure s prisjetljivosti oblika, lijevanje, razvoj mikrostrukture, toplinska obrada, funkcionalna svojstva, korozija]]></keywords_hr><keywords_en><![CDATA[Shape memory alloys, casting, microstructure evolution, heat treatment, functional properties, corrosion]]></keywords_en><summary_hr><![CDATA[Istraživanje u projektu usmjereno je na razvoj legura s prisjetljivosti oblika na bazi bakra. Glavni ciljevi projekta su: kontrola skrućivanja i optimizacija tehnologije lijevanja na temelju mikrostrukturne i termodinamičke simulacije, uspostavljanje korelacije između mikrostrukture i željenih mehaničkih svojstava Cu-SMA legura, optimizacija postupka toplinske obrade s ciljem postizanja željene mikrostrukture, usklađivanje parametara proizvodnje (npr. lijevanja), mikrostrukture i funkcionalnih svojstava legura te razvoj fizikalnog i termodinamičkog modela za predviđanje razvoja mikrostrukture. Predloženi projekt i ciljevi projekta obuhvatit će pripremu jedinstvenih SMA legura s potencijalnom primjenom u strojarstvu i elektronici. Aktivnosti projekta prikazane su kroz osam radnih paketa (RP): RP1-Dizajniranje legura mezoskopskim i mikroskopskim kompjutorskim modeliranjem, RP2- Termodinamičko modeliranje i izrada faznih dijagrama legura, RP3-Priprema pred-legura, RP4-Lijevanje legura i razvoj mikrostrukture, RP5-Toplinska obrada legura, RP6-Karakterizacija legura, RP7-Ispitivanje funkcionalnih svojstava legura, RP8-Upravljanje projektom. Lijevanje legura provest će se pomoću tri tehnologije: lijevanjem u kalupe, kontinuiranim lijevanjem i melt-spinning tehnikom. Legure će se karakterizirati različitim tehnikama (OM, SEM, EDS, TEM, XRD, DSC, DTA, AAS, itd.), kao i njihova funkcionalna svojstva (efekt memorije oblika, korozija i elektrokemijska svojstva, itd.). Postignuti rezultati će osigurati nove poveznice mikrostrukturnih, mehaničkih i funkcionalnih značajki legura te njihovu korelaciju s ciljem pomicanja granica pripreme, lijevanja i toplinske obrade ispitivanih legura. Ishodi prijedloga projekta su od interesa i prihvatljivi za mala i srednja poduzeća usmjerena na proizvodnju Cu-legura s prisjetljivosti oblika.]]></summary_hr><summary_en><![CDATA[The research in the project is focused on the development of Cu-based shape memory alloys (SMA). The main goals of the project are: solidification control and optimization of the casting technology based on the microstructural and thermodynamical simulation, establishing  relationships between microstructure and desired mechanical properties of Cu-SMA, optimization of heat treatment to achieve desired microstructure, fine tuning of the production technology parameters towards the definite microstructure and functional properties of alloys and development of the physical and thermodynamic models capable of anticipating microstructure evolution.The proposed goals pertain to the effort to prepare unique SMAs with potential application in machine-building and electronic purposes. Investigation in this project will consist of eight work packages: WP1-Computational alloy design aided by mesoscopic and microscopic modelling, WP2- Thermodynamic modelling and constitution of alloys phase diagrams, WP3-Preparation of master alloys, WP4-Casting of alloys and microstructure evolution, WP5-Heat treatment of alloys, WP6-Characterization of alloys, WP7-Testing of functional properties of alloys, WP8-Project management. Casting of alloys will be realized by three techniques: casting in moulds, continuous casting and melt spinning technique. Diverse methods for characterization of alloys (OM, SEM, EDS, TEM, XRD, DSC, DTA, AAS, etc.) as well as examination of their functional properties (shape memory effect, corrosion and electrochemical properties, etc.) will be used. The results achieved will provide novel relationships of microstructural, mechanical and functional properties of alloys and their correlations in order to shift the knowledge limit for preparation, casting and heat treatment of investigated alloys. Outcomes of the project proposal will be potentially acceptable for small and medium size companies focused to production of Cu-SMAs.]]></summary_en></project><project>
<id>3189</id><title_hr><![CDATA[Logika, pojmovi i komunikacija]]></title_hr><title_en><![CDATA[Logic, Concepts, and Communication]]></title_en><user_id>91</user_id><user_firstLast_name>Srećko Kovač</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-9378</code><acronim><![CDATA[LogiCCom]]></acronim><duration>15.06.2015 - 14.06.2019</duration><status>Prekinut</status><financ_value>67.237,37 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filozofija, </scie_field_hr><scie_field_en>Philosophy, </scie_field_en><institution_hr><![CDATA[Institut za filozofiju]]></institution_hr><institution_en><![CDATA[Institute for Philosophy in Zagreb]]></institution_en><team_members_id>3883, 3843, 3876, 4482, 13057, 11242, </team_members_id><team_members_names><![CDATA[Kordula Swietorzecka, Majda Trobok, Gabriela Bašić, Goran Lojkić, Ivan Restović, Kristina Šekrst, ]]></team_members_names><keywords_hr><![CDATA[logika, pojam, ontologija, znanje, pragmatika, Kant, Bolzano, Frege]]></keywords_hr><keywords_en><![CDATA[logic, concept, ontology, knowledge, pragmatics, Kant, Bolzano, Frege]]></keywords_en><summary_hr><![CDATA[Cilj je projekta reafirmacija temeljne uloge pojmova kao intenzija u logici kao i formalne pragmatike porabe pojmova u zaključivanju. Taj se cilj želi postići  istraživanjem koje na unutrašnji način povezuje intenzionalni i pragmatički pristup logici.Istraživanje ima četiri glavna aspekta unutar kojih se želi pokazati osnovna uloga pojmova: logika pojmova, pojmovni temelji ontologije, pojmovni temelji znanja i  društvena pragmatika pojmova.1) Istražit će se intenzionalna narav pojmova kao osnovanih na logičkim radnjama apstraktnih činitelja koji zaključuju (apstraktna pragmatika). Ispitat će se moguće intenzionalno podrijetlo klasičnih logičkih zakona. Pojmovima će se pristupiti  sa stajlišta logike prvoga reda i teorije tipova. Želi se ispitati hipoteza prema kojoj se intenzionalna logika i logički pojmovi mogu opisati pomoću pojmova objektivnosti i (prema Gödelovoj hipotezi)  uzročnosti.2) Ispitat će se intenzionalna bit temeljnih ontologijskih pojmova na primjeru  formalizacije Bolzanove ontologijske teorije, u usporedbi s Leibnizovom ontologijom. Istraživanje će se usredotočiti na pojmove supstancije, adherencije/inherencije i cjelina-dio.3) Želi se pokazati doprinos pojmova objektivnoj vrijednosti znanja, osobito  u  matematici, i u oslonu na Fregeovu teoriju pojmova. Posebno će se istraživati međuodnos pojmovnoga i predmetnoga sadržaja u analitičnim iskazima i iskazima prvoga reda.4) Analizirat će se uzročna uloga logičkih pojmova i jezika u kontekstu njihove porabe u govornim činovima i argumentacijskome dijalogu. Pokazat će se da je pragmatika bitna sastavnica logike, te da se, kao i sintaksa i semantika, može rigorozno formalizirati. Ktomu, istraživanje želi pokazati da je uporaba logike i jezika primarni izvor opisa pojmova.]]></summary_hr><summary_en><![CDATA[The project aims at re-establishing the fundamental role of concepts as intensions in logic as well as of formal pragmatics of the use of concepts in reasoning. This aim is to be achieved by means of the research that will intrinsically interconnect the intensional and pragmatic approach to logic. The research has four main aspects within which the basic role of concepts is aimed to be shown: logic of concepts, conceptual foundations of ontology, conceptual foundations of knowledge, and social pragmatics of concepts.1) The intensional nature of concepts will be investigated as based on logical operations of abstract reasoning agents (abstract pragmatics). A possible intensional origin of classical logical laws will be examined. Concepts will be approached in first-order and type-theoretical setting as well. One hypothesis to be examined is that intensional logic and logical concepts can be described in terms of objectivity and (according to Gödel’s hypothesis) in terms of causality.2) The intensional nature of some fundamental ontological concepts will be examined on the example of the new formalization of Bolzano’s ontological theory, in comparison Leibniz&#39;s  ontology. The research will focus on the concepts of substance, adherence/inherence, and whole-part.3) The contribution of concepts to the objective value of knowledge is aimed to be shown, especially in mathematics, and starting from Frege’s theory of concepts. Especially, the interrelationship of the conceptual and objectual content in analytic and first-order propositions will be investigated.4) The causal role of logical concepts and language in the context of their use in speech acts and argumentative dialogue will be analysed. Pragmatics will be shown to be an essential constituent part of logic, which is, like syntax and semantics, apt to be rigorously formalized. In addition, the research aims to show that the use of logic and language is a primary source of the description of concepts.]]></summary_en></project><project>
<id>3190</id><title_hr><![CDATA[Potraga za aksionima i njima sličnim česticama]]></title_hr><title_en><![CDATA[Search for axions and axion-like particles]]></title_en><user_id>1471</user_id><user_firstLast_name>Biljana Lakić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-3720</code><acronim><![CDATA[SAALP]]></acronim><duration>01.05.2015 - 31.10.2017</duration><status>Završio</status><financ_value>44.409,05 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>1086, 619, 501, 1037, 5714, </team_members_id><team_members_names><![CDATA[Krešimir Jakovčić, Milica Krčmar, Ante Ljubičić, Marin Karuza, Nenad Kralj, ]]></team_members_names><keywords_hr><![CDATA[eksperimentalna fizika, tamna tvar, aksion, čestice slične aksionima, lagane čestice s vrlo slabim međudjelovanjima, CAST, IAXO]]></keywords_hr><keywords_en><![CDATA[experimental physics, dark matter, axion, axion-like particle, weakly interacting slim particles, CAST, IAXO]]></keywords_en><summary_hr><![CDATA[Cilj predloženog projekta je istražiti postojanje i svojstva nekih čestica koje su kandidati za tamnu tvar u svemiru. Najnoviji podaci pokazuju da se svemir sastoji od obične tvari (4.9%), tamne tvari (26.8%) i tamne energije (68.3%). Jedan od glavnih pravaca istraživanja u današnjoj fizici usmjeren je na otkrivanje sastava tamne tvari. Prema sadašnjim spoznajama većinu tamne tvari čine čestice koje do sada još nisu opažene nego je njihovo postojanje samo predviđeno u raznim proširenjima Standardnog modela čestica. Prema tim teorijama postoje dva glavna kandidata za tamnu tvar. To su tzv. masivne čestice s vrlo slabim međudjelovanjima (WIMP od eng. Weakly Interacting Massive Particles) i aksion – lagani pseudoskalar koji se pojavljuje kao posljedica spontanog lomljenja U(1) Peccei-Quinn simetrije izvorno uvedene radi objašnjenja odsustva narušenja CP simetrije u jakim međudjelovanjima. Poopćenjem tog koncepta predviđeno je postojanje mnoštva čestica sličnih aksionima (ALP od eng. axion-like particles). Kao mogući kandidati za tamnu tvar spominju se i razne lagane čestice s vrlo slabim međudjelovanjima (WISP od eng. Weakly Interacting Slim Particles) predviđene u nekim proširenjima Standardnog modela, kao npr. parafotoni i kameleoni. Unatoč velikom broju hipoteza postavljenih s ciljem objašnjenja koje čestice čine tamnu tvar, samo eksperimenti mogu pokazati koja od njih je točna.U predloženom projektu planiramo nastaviti i proširiti potragu za aksionima, ALPovima i WISPovima u eksperimentima CAST (CERN Axion Solar Telescope) - trenutno najosjetljivijem aksionskom helioskopu i njegovom nasljedniku IAXO (International Axion Observatory). Otkriće tih čestica bilo bi revolucionaran rezultat jer bi to bio jasan dokaz o postojanju fizike izvan Standardnog modela. Međutim, čak i ako se ne otkriju te čestice, isključiti će se velik dio do sada neistraženog parametarskog prostora tih čestica što je također vrlo važan rezultat.]]></summary_hr><summary_en><![CDATA[The goal of the proposed project is to search for and study several candidates for the dark matter. Recent data from the Planck mission show that our Universe contains 4.9% ordinary matter, 26.8% dark matter and 68.3% dark energy. One of the major efforts in particle physics today is to reveal the composition of the dark matter. Nowadays, it is known that neutrinos constitute only a tiny fraction of the dark matter, while the rest is made of yet unobserved particles theoretically predicted in various extensions of the Standard Model. Two leading dark-matter candidates are the Weakly Interacting Massive Particles (WIMPs), and the axion - a light pseudoscalar associated with the spontaneous breaking of U(1) Peccei-Quinn symmetry, a mechanism originally introduced to explain the absence of CP violation in strong interactions. This concept has been generalized to further axion-like particles (ALPs), which may arise as Nambu-Goldstone bosons from the breaking of various global symmetries.  Possible dark matter candidates also include so-called WISPs, i.e., a variety of sub-eV (or slim) weakly-coupled particles such as hidden-sector photons and chameleons. A large number of theoretical ideas and hypotheses have been put forward to explain what the dark mater particles are, but only experimental data will be able to answer which, if any, of these ideas is correct. In the proposed project we are planning to continue and extend searches for axions, ALPs, and WISPs in experiments CAST (CERN Axion Solar Telescope) - currently the most sensitive axion helioscope in the world and its successor IAXO (International Axion Observatory). The discovery of such particles would be a ground-breaking result for particle physics since it would be a clean evidence of physics beyond Standard Model, but even in case of non-detection, CAST and IAXO will be able to exclude large parts of yet unexplored regions of the relevant parameter spaces for these particles.]]></summary_en></project><project>
<id>3204</id><title_hr><![CDATA[Multiferoični i magnetoelektrični sustavi]]></title_hr><title_en><![CDATA[Multiferroic and magneto-electric systems]]></title_en><user_id>2787</user_id><user_firstLast_name>Damir Pajić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2014-09</proposal_call><code>UIP-2014-09-8276</code><acronim><![CDATA[FerMaEl]]></acronim><duration>01.06.2015 - 31.10.2019</duration><status>Završio</status><financ_value>115.336,12 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>2873, 634, 12831, 6058, 4933, 5693, 6173, 20695, </team_members_id><team_members_names><![CDATA[Nikolina Novosel, Mirta Rubčić, Marijana Jurić, Filip Torić, Vito Despoja, Krešo Zadro, Emil Babić, Jure Dragović, ]]></team_members_names><keywords_hr><![CDATA[multiferoici, magneto-električni učinak, metalni oksidi, metalo-organske mreže, magnetizacija, polarizacija, teorija funkcionala gustoće]]></keywords_hr><keywords_en><![CDATA[multiferroics, magneto-electric effect, metallic oxides, metal-organic frameworks, magnetization, polarization, density functional theory]]></keywords_en><summary_hr><![CDATA[Multiferoici su materijali u kojima istovremeno postoje i magnetsko i električno uređenje, što je važno i za temeljnu fiziku i za primjene, poglavito zbog mogućeg vezanja dvije vrste reda. Iako mnogi materijali pokazuju posredne znakove magneto-električnog vezanja, izravne eksperimentalne činjenice mogle bi unaprijediti naše znanje o mehanizmima vezanja i postojanja dva uređenja. Stoga bi nadogradnja postojećih SQUID i VSM magnetometara omogućujući istraživanje utjecaja električnog polja na magnetizaciju, kao i izgradnja instrumentacije za mjerenje električne polarizacije  u primijenjenom magnetskom polju unutar postojećih kriostata, otvorila široke mogućnosti za magneto-električno istraživanje multiferoika. Multiferoičnost se javlja u različitim skupinama materijala, a istraživanje će biti usmjereno na one obećavajuće. Nove metalo-organske mreže vrlo su perspektivne, te ćemo raditi na njihovoj sintezi i modifikacijama, radi razumijevanja i utjecanja na njihovo magneto- električno ponašanje. Također, ne-centrosimetrični miješani metalni oksidi, kao i njihove nanočestice, pružaju široke mogućnosti  sinteze i modifikacije multiferoičnih svojstava. Predloženo multidisciplinarno istraživanje rezultiralo bi novim spojevima i izgrađenom aparaturom za potpunu magnetsku i električnu karakterizaciju potrebnu pri istraživanju multiferoika, dajući cjelovit skup eksperimentalnih činjenica upotpunjenih detaljnim teorijskim računima. Zajednički rad doveo bi do razvoja nezavisne istraživačke karijere i nastanka nove istraživačke skupine, jačajući suradnju i izobrazbu. Sveukupno bi omogućila plodno okruženje za kompetitivnu uključenost u istraživanja na svjetskoj razini unutar te aktualne teme u fizici čvrstog stanja i znanosti o materijalima, okupljanjem ljudskih i drugih znanstvenih resursa oko proizvodnje novih multiferoičnih sustava te njihovog cjelovitog eksperimentalnog i teorijskog proučavanja.]]></summary_hr><summary_en><![CDATA[Multiferroics are materials where the magnetic and electric orders coexist, being important for fundamental physics and applications, especially due to possible coupling of the two orders. While many materials show the indirect signs of the magneto-electric coupling, the direct experimental evidences could still improve our knowledge about mechanisms of the coupling and coexistence of two orders. Therefore, the upgrade of the existing SQUID and VSM magnetometers enabling investigation of influence of the electric field onto the magnetization, and also build up of instrumentation for measurement of electric polarization in applied magnetic field, would open large possibilities for magneto-electric research of the multiferroics. Multiferroicity appears in different groups of materials and investigation would be focussed on especially promising. New metal-organic frameworks are very perspective, and we will be working on their synthesis and modifications, in order to understand and influence their magneto-electric behaviour. Further, non-centrosymmetric metallic oxides, as well as their nanoparticles, offer large possibilities for the synthesis and modification of multiferroic properties. Proposed multidisciplinary research would result with the novel compounds and installed equipment for complete magnetic and electric characterization needed in research of multiferroics, giving integral set of experimental results, supplemented with detailed theoretical calculations. Joint work would lead to development of the independent research careers and growth of new team, strengthening the collaboration and education. It would enable the fertile environment for the competitive involvement in the research at international level within this state-of-the-art topic of condensed matter physics and materials science, because of assembling the human and other scientific resources around production of the new multiferroic systems and their complete experimental and theoretical study.]]></summary_en></project><project>
<id>3214</id><title_hr><![CDATA[Subplate zona ljudskog mozga: neriješeni problemi]]></title_hr><title_en><![CDATA[Subplate zone of the human brain: unsolved problems]]></title_en><user_id>12951</user_id><user_firstLast_name>Ivica  Kostović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-4517</code><acronim><![CDATA[HUMANSUBPLATE]]></acronim><duration>01.01.2016 - 31.12.2019</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>7740, 12673, 12564, 12680, 12767, 12640, 12758, 13017, 12900, 12824, 4298, 12740, 12815, 23535, 23501, 25350, 25408, 25356, 22457, 22464, </team_members_id><team_members_names><![CDATA[Miloš Judaš, Dora Mandić, Ana Katušić, Branka Bartolić Spajić, Branka Bunoza, Valentina Galkowski, Ana Jagušt, Božica Popović, Danica Budinšćak, Marina  Raguž, Milan Radoš, Mirna  Kostović Srzentić , Vesna Benjak, Ruža Grizelj, Tomislav Ćaleta, Ana Bogdanić, Gabriela Plosnić, Lana Vasung, Iris Žunić Išasegi , Tomislav Gojmerac, ]]></team_members_names><keywords_hr><![CDATA[subplate, prematurus, vulnerabilnost, moždana kora, razvitak]]></keywords_hr><keywords_en><![CDATA[subplate, preterm infant, vulnerability, cortex, development]]></keywords_en><summary_hr><![CDATA[Subplate zona je najistaknutiji i najvoluminozniji arhitektonski odjeljak stijenke telencefalona u mozgu čovjeka, s ključnom ulogom u razvoju neuronskih veza moždane kore. Istraživanja su pokazala da ta zona ima rano razvojno porijeklo, sadrži brojne sinapse i neurone složenih citoloških svojstava i molekularne raznovrsnosti, uključena je u razvoj aferentnih aksona iz talamusa, kao i uspostavu privremenih neuronskih veza, prolaznu ekspresiju neurotransmitera, neuronskih krugova moždane kore i njihovu funkcionalnu specifikaciju, evoluciju moždane kore te patogenezu neuroloških, kognitivnih i mentalnih poremećaja. Brojna pitanja bitna za humanu razvojnu neurobiologiju ostala su neriješena: Kako se subplate povećava tijekom trudnoće? Kakva je sublaminarna, sinaptička, neuronalna i glijalna organizacija? Kakva je uloga u migraciji neurona? Kakvi su odnosi subplatea s dugim asocijativnim kortiko-kortikalnim vezama? Kakva je postnatalna sudbina? Postoji li selektivna vulnerabilnost subplate neurona i različitih klasa aksona i kako to prikazati u in vivo MRI? Naša je hipoteza da će veličina, karakteristični neuralni sadržaj i produljeni razvitak zajedno s karakterističnim svojstvima na MRI omogućiti prikaz onih karakterističnih osobina ljudskog subplatea koje su povezane sa složenošću kortikalnih veza. Specifični ciljevi su određeni da odgovore na gore navedena pitanja, primjenom histoloških, imunocitokemijskih i in vitro, in utero te in vivo MRI tehnika u mozgu čovjeka, kao i usporedbom tih podataka s nalazima u majmuna tretiranih s H3-Thymidine markerom replikacije DNA (Rakic, Yale). Rezultati ovog projekta će omogućiti bolji uvid u razvitak osjetljivog mozga fetusa i prijevremeno rođene djece, proširiti normativne podatke za pedijatrijski neuroimaging i studije praćenja koje su usmjerene na razvoj kortikalnih veza, te omogućiti dobre polazne osnove za istraživanje neuroloških, kognitivnih i mentalnih poremećaja, koji imaju utjecaj na društvo. ]]></summary_hr><summary_en><![CDATA[Subplate zone is the most prominent and voluminous, connectivity related, compartment of the cerebral wall of developing primate brain playing different developmental roles. Studies of this enigmatic neuronal compartment in human brain and experimental models have demonstrated early origin, synapse-rich content, complex cytology and molecular diversity, involvement in growth of thalamo-cortical fibres, transient connectivity and transmitter expression, functional specificity, role in formation of cortical circuitry, evolutional significance and prospective role in pathogenesis of neurological, cognitive and mental disorders. Review of the current literature indicate gaps in the our knowledge and existence of unsolved problems regarding secondary expansion of subplate, sublaminar distribution of synapses and different phenotypes of migratory and postmigratory neurons, transformation of radial glia, pattern of growth of long associative cortico-cortical pathways and vulnerability of subplate (axons, neurons and glia in preterm infant). It is our hypothesis that size characteristic neuronal content and prolonged development, together with MR imaging properties, will facilitate demonstration of those characteristic features of the human (primate subplate), which are related to the complexity of cortical connectivity. In this project, we will use histological, immunocytochemical and MR imaging techniques (in vitro and in vivo) for developing human brain, as well as comparative analysis of experimental non-human primate (provided by dr. Rakic, Yale) in order to give answers for unsolved problems in human SP neurobiology. We expect to demonstrate characteristic features of the human subplate related to complex cortical connectivity, develop new diagnostic criteria for MR imaging and follow-up of perinatally damaged brain and define novel normative data necessary for study of developmental neurological, cognitive and mental disorders, which have severe impact on society.]]></summary_en></project><project>
<id>3217</id><title_hr><![CDATA[Prema kvantnoj gravitaciji: nekomutativna geometrija, teorija polja i kozmologija]]></title_hr><title_en><![CDATA[Toward quantum gravity: noncommutative geometry, field theory and cosmology]]></title_en><user_id>1041</user_id><user_firstLast_name>Stjepan Meljanac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-9582</code><acronim><![CDATA[tqgngftc]]></acronim><duration>01.09.2015 - 30.11.2017</duration><status>Završio</status><financ_value>66.361,40 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>12415, 12532, 2912, 3128, 3176, 2750, 12905, 1153, </team_members_id><team_members_names><![CDATA[Nevenko Bilić, Silvije Domazet, Josip Trampetić, Raul Horvat, Jiangyang You, Tajron Jurić, Danijel Pikutić, Anđelo Samsarov, ]]></team_members_names><keywords_hr><![CDATA[kvantna gravitacija, nekomutativna geometrija, teorija polja, kozmologija, simetrije]]></keywords_hr><keywords_en><![CDATA[quantum gravity, noncommutative geometry, field theory, cosmology, symmetries]]></keywords_en><summary_hr><![CDATA[Predloženi projekt ima za cilj provođenje istraživanja o različitim aspektima kvantne gravitacije, matematičke fizike, određenim temama u kozmologiji, astro fizici i fizici crnih rupa. Dok  zadovoljavajuća teorija kvantne gravitacije i dalje ostaje nedostižna, neka od procijenjenih svojstava, otkrivajući nelokalni karakter takve teorije (odnosno nekomutativnost prostorno-vremenskih koordinata, UV/IR  miješanje i holografski princip) već su promijenila našu perspektivu pomirenja  kvantne teorije polja (QFT) s općom teorijom relativnosti. Posebna pažnja posvetiti će se izgradnji, klasifikaciji i unifikaciji nekomutativnih (NC) prostora. U vezi s tim, moguće je definirati proceduru korištenjem rigoroznih tehnika kvantne deformacije kao i nekih dobro poznatih koncepata diferencijalne algebre i Hopfove algebre. To omogućuje formulaciju i proučavanje twist-deformirane Riemannove geometrije, twist verzije Einsteinovih jednadžbi i algebarskih struktura na kapa-deformiranom prostoru Minkowskog. Daljnji nastavak tih ideja otvara mogućnost proučavanja NC efekata u  crnim rupama. Osim toga, pomoću alata  QFT u zakrivljenom prostoru-vremenu, biti će pokriveno više aspekata moderne kozmologije, uključujući one koje se temelje na najuspješnijem ostvarenju holografskog principa –  AdS/ CFT dualnosti. Konačno, klasa modela kvantne gravitacije  bit će ispitana testiranjem narušenja Lorentzove invarijantnosti u promatranju brzo-promjenljivih astrofizičkih izvora visoko  energijskih gama-zraka. To zahtijeva potpuni model teorije polja  u kojem se ne javljaju problemi pri računanju  kvantnih petlji, tako da su  sve UV i IR patologije  pod kontrolom.]]></summary_hr><summary_en><![CDATA[The proposed project aims at carrying out research on various aspects of quantum gravity, related areas of mathematical physics, certain topics in cosmology, astroparticle physics and physics of black holes. Whereas a satisfactory theory of quantum gravity still remains elusive, some of the assessed properties revealing a nonlocal character of such a theory (i. e. noncommutativity of spacetime coordinates, UV/IR mixing and the holographic principle) has already changed our perspective upon reconciliation of the  quantum field theory (QFT) framework with general relativity. A particular attention will be paid to construction, classification and unification of NC spaces. In this regard, a procedure can be defined by making use of rigorous quantum deformation techniques as well as some well known differential algebra concepts and also  the Hopf algebra methods. This permits formulation and study of the twist-deformed Riemannian geometry, the twisted version of Einstein&#39;s equations and the algebraic structure on kappa-deformed Minkowski space. A further extension of these ideas opens  a possibility to study NC effect in black holes. Furthermore, using the tools of QFT in curved spacetime, several aspects of modern cosmology will be covered including those based on the most successful realization of the holographic principle - the AdS/CFT duality. Finally, a class of quantum gravity models will be tested by probing Lorentz violation in observations of rapidly-varying astrophysical sources of high-energy gamma-rays. This requires a full-fledged field-theoretical model with a trouble-free and meaningful quantum loop results, with all UV and IR pathologies being under control.]]></summary_en></project><project>
<id>3220</id><title_hr><![CDATA[Kronične upalne bolesti crijeva u djece: incidencija, tijek bolesti te uloga prehrane i crijevne mikroflore u etiopatogenezi]]></title_hr><title_en><![CDATA[Pediatric inflammatory bowel disease: incidence and natural history, and the role of diet and gut flora in etiopathogenesis]]></title_en><user_id>5694</user_id><user_firstLast_name>Sanja Kolaček</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-3788</code><acronim><![CDATA[PED-IBD]]></acronim><duration>01.03.2016 - 31.03.2020</duration><status>Završio</status><financ_value>106.178,25 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Kliničke medicinske znanosti, Javno zdravstvo i zdravstvena zaštita, </scie_field_hr><scie_field_en>Clinical sciences, Public health and health services, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu]]></institution_hr><institution_en><![CDATA[University of Zagreb]]></institution_en><team_members_id>2694, 5757, 4001, 5833, 4795, 2960, 4107, 25201, </team_members_id><team_members_names><![CDATA[Iva Hojsak, Ana Močić Pavić, Marko Jelić, Goran Palčevski, Zrinjka Mišak, Irena Senecic-Cala, Arjana Tambić - Andrašević, Ivana Trivić, ]]></team_members_names><keywords_hr><![CDATA[upalne bolesti crijeva, djeca, crijevna flora, enteralna prehrana, incidencija, registar]]></keywords_hr><keywords_en><![CDATA[inflammatory bowel disease, children, enteral nutrition, incidence, registry]]></keywords_en><summary_hr><![CDATA[Etiologija i patogeneza kroničnih upalnih bolesti crijeva (IBD - inflammatory bowel disease), unatoč visokoj prevalenciji, nisu razjašnjene. Predloženi mehanizam uključuje interakciju neodgovarajućeg (aberantnog) imunološkog odgovora na crijevnu mikrofloru / crijevni sadržaj, u genetski predisponiranih osoba. Cilj je ovog istraživačkog projekta pridonijeti rasvjetljavanju navedene patogeneze.Ciljevi. 1. Prehrana. Bolesnici s IBD-om vrlo često izbjegavaju određene namirnice u prehrani, pridajući im – po njihovu bolest – neželjena svojstva. Međutim, učinak takvih samonametnutih dijeta nije do sada istražen i za takve dijetetske postupke zasad nema znanstveno utemeljnog opravdanja. Od posebne je to važnosti za djecu u koje ozbiljnije dijetetske restrikcije mogu imati dugoročne posljedice na rast i razvitak. Stoga je prvi cilj ovog projekta utvrditi učestalost samoiniciranih dijeta u djece s IBD-om i procijeniti njihov učinak na: a) nutritivni status koristeći strogo definirane parametre, b) tijek bolesti. U istraživanje će se uključiti novodijagnosticirani bolesnici s IBD-om te zdrave kontrole.2. Crijevna mikroflora. Znanstveno je potvrđena terapijska učinkovitost isključive enteralne prehrane (EEN - exclusive enteral nutrition) na aktivnu formu Crohnove bolesti (CD) u djece, koja se, dijelom, pripisuje utjecaju na crijevnu mikrofloru. Međutim, dokaza o njihovoj povezanosti zasad nema. Stoga je drugi cilj ovog istraživanja utvrditi razliku u crijevnoj mikroflori u trenutku postavljanja dijagnoze i nakon indukcije remisije sa EEN. Crijevna mikroflora bolesnika usporedit će se s crijevnom mikroflorom zdravog brata ili sestre oboljelog djeteta i to neposredno prije, i dva dana nakon početka EEN. Nadalje, u djece s CD crijevna će se mikroflora odrediti i nakon završetka EEN te svakih dva mjeseca tijekom cijele prve godine praćenja. 3. PED-IBD registar. Do sada nije utvrđena incidencija, tijek i ishod bolesti („natural history“) u djece oboljele od IBD-a u Republici Hrvatskoj. Slijedom navedenoga, treći je cilj našeg projekta utemeljiti nacionalni registar djece s IBD-om s on-line bazom podataka koja će sadržavati sve važne kliničke i dijagnostičke parametre u sve djece s novodijagnosticiranom bolesti u Hrvatskoj. Podaci o bolesniku unositi će se kod dijagnoze i nakon godine dana praćenja. Za određivanje rizičnih čimbenika za nastanak relapsa koristit će se multivarijatna analiza koja će uključiti kliničke i terapijske parametre. ]]></summary_hr><summary_en><![CDATA[The etiology and pathogenesis of inflammatory bowel disease (IBD) have not been fully elucidated. 1. Diet. Patients with IBD, despite the absence of scientific evidence, often avoid certain types of food; however the effect of those self-imposed diets has not been determined. This is especially important in children whereby insufficient diet could have long-term consequences on growth and development. Therefore, the first objective of our study is to determine the frequency of self-induced diets in children with IBD and their impact on: a) nutritional status by using clearly defined parameters and b) course of the disease. The study will include newly diagnosed patients with IBD and healthy controls. 2. Intestinal microflora. It has been hypothesized that the excellent therapeutic effect of exclusive enteral nutrition (EEN) on pediatric active Crohn&#39;s disease (CD) could be explained by the effect on intestinal microflora. However, well performed studies are lacking. Therefore, the second objective of our study is to determine the difference in gut microflora at diagnosis and after remission induction achieved with EEN. Patients’ intestinal microflora will be compared with the microflora of healthy siblings before and two days after both groups receive EEN. Furthermore, in children with CD the intestinal microflora will be determined after 6 weeks of EEN and during the first year of follow up.  3. PED-IBD Registry. The incidence and natural history of pediatric IBD in Croatia has not been determined yet. The third goal of our project is to establish a national registry of children with IBD by providing an on-line database that will contain relevant clinical and diagnostic factors on all newly diagnosed pediatric IBD patients. To achieve this goal data will be entered at diagnosis and after one year of follow up. Multivariate analysis, which will include clinical and therapeutic parameters, will be used to determine risk factors for early disease relapse.]]></summary_en></project><project>
<id>3224</id><title_hr><![CDATA[Biomarkeri u shizofreniji – integracija komplementarnih prisutupa u praćenju osoba s prvom psihotičnom epizodom]]></title_hr><title_en><![CDATA[Biomarkers in schizophrenia – integration of complementary methods in longitudinal follow up of first episode psychosis patients ]]></title_en><user_id>5485</user_id><user_firstLast_name>Martina Rojnic Kuzman</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2014-09</proposal_call><code>UIP-2014-09-1245</code><acronim><![CDATA[BIS – LF FEP]]></acronim><duration>01.08.2015 - 31.03.2019</duration><status>Završio</status><financ_value>106.178,25 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Clinical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>13000, 12759, 13269, 13311, 4713, 5007, 13330, 13208, 4369, 5787, 12762, 13342, 6334, 13515, 13496, 13313, 13510, 2549, 3483, </team_members_id><team_members_names><![CDATA[Zoran Madžarac, Ivana Kekin, Ratimir Petrović, Aleksandar Savić, Lana Ganoci, Nada Božina, Željka Vogrinc, Nina Mayer, Tamara Božina, Branko Malojčić, Dina Bošnjak, Marina Boban, Maja Živković, Daniel J. Mueller (Müller), Igor Filipcic, Vladimir Grošić, Marina Šagud, Ana Hladnik, Sanja Darmopil, ]]></team_members_names><keywords_hr><![CDATA[shizofrenije, prva epizoda, prospektivno praćenje, neuroimaging, farmakogenetika, post mortem]]></keywords_hr><keywords_en><![CDATA[schizophrenia, first episode; prospective follow up, neuroimaging, pharmacogenetics, post mortem]]></keywords_en><summary_hr><![CDATA[Shizofrenija je jedna od najtežih psihijatrijskih bolesti, koje pogađa oko 1% populacije. Iako su mnoga su istraživanja usmjerena potrazi biomarkera tijeka bolesti i liječenja, još nije utvrđen biološki pokazatelj shizofrenije. Stoga je potreba revizija dosadašnje  metodologije, uključujući:  1) prospektivna istraživanjima na dobro definiranom uzorku bolesnika s prvom psihotičnom epizodom (PPE) koja ne bi imala ograničenja dosadašnjih istraživanja (npr. transverzalni dizajn, heterogeni uzorak bolesnika, primjenu različitih lijekova); 2) integraciju više pristupa koji zajednički ukazuju na predispoziciju za shizofreniju. Rezultati genetičkih istraživanja upućuju da shizofrenija nastaje uslijed međuinterakcije gena i okoliša, ponovo revitalizirajući model stres dijateze u razvoju shizofrenije.Stoga planiramo istražiti set biomarkera prema tom modelu uključujući psihopatološki status, neurokognitivno funkcioniranje te odgovor na stres koristeći funkcionalne i neuroslikovne prikaze mozga (Single photon emission computed tomography - SPECT) u 150 PPE bolesnika. Istražit ćemo razlike potencijalnih biomarkera u odnosu na kontrole, te njihove promjene u psihozi i kasnijoj remisiji kroz 18-mjesečno prospektivno praćenje. Dobivene rezultate ćemo koristiti u procjeni povezanosti terapijskog odgovora i farmakogenetičkih biljega. Istraživanje cjelokupnog genoma (Genome wide association study - GWAS) ćemo provoditi u suradnji s istraživačkom grupom iz Toronta. Obzirom na rezultate dobivenih in-vivo funkcionalnih i imaging istraživanja učiniti ćemo analizu broja i distribucije, te morfoloških i kemijskih osobitosti specifičnih tipova neurona u histološki obrađenom kortikalnom tkivu iz post mortem uzoraka osoba sa shizofrenijom u odgovarajućim regijama mozga.Projekt je nastavak naših ranijih istraživanja, ali i uvodi novi multidisciplinarni pristup u okrivanju biomarkera u PPE. Rezultati ovog istraživanja će stoga doprinijeti znanstvenim spoznajama na internacionalnoj razini.]]></summary_hr><summary_en><![CDATA[Schizophrenia is one of the most disabling psychiatric illnesses, affecting about 1% of population worldwide. Efforts have been made to identify a biological correlate of schizophrenia yet without straightforward results. Thus, the methodology in the search of biomarkers has to be revised including: 1) longitudinal studies of first episode schizophrenia (FEP) patients, to overcome the confounders from previous studies (i.e. cross sectional design, heterogeneous sample of patients, confounding effects of medication); 2) integration of different approaches when searching for biomarkers. A large body of genetic studies concluded that schizophrenia results from the gene x environment interaction and once again revitalized the stress diathesis model of schizophrenia. Thus, we will examine a set of biomarkers according to this model including the psychopathological status, neurocognitive functioning and stress response by using brain functional and neuroimaging (single photon emission computed tomography - SPECT) methods in 150 FEP patients vs. controls and their changes during the FEP and subsequent remission in 18-month longitudinal follow up. Secondly, we will examine the course of treatment of previously unmedicated FEP patients by using pharmacogenetic analysis. Genome wide association studies (GWAS) will be performed in collaboration with the research group of Toronto, further expanding our international collaboration. We will study alteration in number and distribution, as well as morphology and chemical properties of specific neuron subclasses in histologically prepared human cortical tissue of schizophrenic subjects in the region that synaptic alteration was suggested by in-vivo functional and structural imaging (SPECT).This project is a continuation of our previous studies, but it also brings a innovative multidisciplinary approach to identify biomarkers in FEP. The results of this study will thus contribute to the scientific knowledge on international level.]]></summary_en></project><project>
<id>3230</id><title_hr><![CDATA[Optomehanika uzrokovana frekventnim češljem]]></title_hr><title_en><![CDATA[Frequency-comb-induced optomechanics]]></title_en><user_id>5410</user_id><user_firstLast_name>Ticijana Ban</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-7342</code><acronim><![CDATA[MeCombO]]></acronim><duration>01.09.2015 - 31.08.2019</duration><status>Završio</status><financ_value>131.315,95 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut za fiziku]]></institution_hr><institution_en><![CDATA[Institute of Physics in Zagreb]]></institution_en><team_members_id>5742, 5029, 5776, 5617, 5890, 24455, 25234, 25432, </team_members_id><team_members_names><![CDATA[Aleksandra Foltynowicz, Damir Aumiler, Hrvoje Buljan, Piotr Maslowski, Roman Ciuryło, Ivor Krešić, Mateo Kruljac, Domagoj Kovačić, ]]></team_members_names><keywords_hr><![CDATA[optomehanika, frekventni češalj, optička šupljina, spektroskopija, koherencija, hladni atomi, rubidij, magneto-optička zamka (MOT), dipolna zamka]]></keywords_hr><keywords_en><![CDATA[optomechanics, frequency comb, optical cavity, spectroscopy, coherence, cold atoms,rubidium, magneto-optical trap (MOT), optical dipole trap]]></keywords_en><summary_hr><![CDATA[Sila na atome uzrokovana kontinuiranim (eng. continuous wave, cw) laserima predstavlja centralni dio istraživanja u području atomske fizike već zadnjih nekoliko desetljeća. Radijativna sila čini osnovu za lasersko hlađenje i zarobljavanje atoma, čime je omogućeno stvaranje dovoljno gustih i hladnih atomskih uzoraka. Ipak, unatoč opsežnom i dobro shvaćenom području optomehanike uzrokovane cw laserom, istraživanja sila na atome uslijed interakcije s nizom ultrakratkih pulseva (odnosno frekventnim češljem) su oskudna. U međuvremenu, rezultati istraživanja provedenih u našoj grupi ukazuju na to da se, u specifičnoj geometriji pobude atoma frekventnim češljem, javljaju posve novi fenomeni koji zahtjevaju dodatna eksperimentalna i teorijska istraživanja.  Cilj ovog projekta je istraživanje novih fenomena koji se javljaju uslijed dijelovanja sile na atome uzrokovane frekventnim češljem (FC), a uključuje fenomene sprezanja i dekoherencije, stvaranja dipolne zamke s fs laserima u blizini atomske rezonancije te hlađenje atoma u optičkoj šupljini (rezonatoru) uzrokovano FC-om. Predložena istraživanja otvorit će nekoliko intrigantnih tema u području istraživanja koje je relevantno znanstvenoj zajednici širom svijeta. Predloženi će projekt utjecati na podizanje prepoznatljivosti hrvatske znanosti u svijetu, zapošljavanje i usavršavanje mladih istraživača i jačanje kapaciteta Instituta za fiziku putem međunarodne suradnje.]]></summary_hr><summary_en><![CDATA[Inducing mechanical action on atoms by continuous wave (cw) laser excitation has been a central topic in atomic physics for decades. Yet, in contrast to the rich and fruitful field of cw-laser-induced optomechanics, the investigations of mechanical action on atoms due to interaction with trains of ultrashort laser pulses (i.e. frequency combs) are scarce in literature. Meanwhile, recent results made in our group have indicated that in a specific excitation geometry an entirely new type of FC-atom interaction emerges that calls out for further experimental and theoretical investigation.The aim of the project is to explore novel phenomena that arise when the mechanical action on cold atoms is induced by frequency comb (FC) excitation, including entanglement and decoherence, near-resonance dipole trap, and frequency-comb-induced cavity cooling. The proposed research will open up several intriguing topics in the field of research that is relevant to the scientific community worldwide.The proposed project will increase the visibility of Croatian science, employ and educate young researchers and strengthen the capacity of the Institute of Physics through international cooperation.]]></summary_en></project><project>
<id>3233</id><title_hr><![CDATA[Serotonergična modulacija pretilosti: međuovisnost regulatornih molekula i puteva]]></title_hr><title_en><![CDATA[Serotonergic modulation of obesity: cross-talk between regulatory molecules and pathways]]></title_en><user_id>5668</user_id><user_firstLast_name>Lipa Čičin-Šain</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-7827</code><acronim><![CDATA[SERT-OB]]></acronim><duration>01.09.2015 - 30.01.2020</duration><status>Završio</status><financ_value>124.241,82 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, Clinical sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>12412, 519, 12665, 12368, 5996, 12354, 21389, </team_members_id><team_members_names><![CDATA[Darko Orešković, Jasminka Štefulj, Darko Kolarić, Gordana Mokrović, Maja Kesic, Marina Horvatiček, Petra Baković, ]]></team_members_names><keywords_hr><![CDATA[serotonin, pretilost, adipociti, hipotalamus, leptin, životinjski model]]></keywords_hr><keywords_en><![CDATA[serotonin, obesity, adipocytes, hypothalamus, leptin, animal model]]></keywords_en><summary_hr><![CDATA[Održavanje energetske ravnoteže organizma kompleksan je proces koji uključuje interakciju različitih centralnih i perifernih regulatornih molekula. Uloga neurotransmitera serotonina (5HT) u modulaciji unosa hrane odavno je poznata, no rezultati novijih istraživanja na životinjama sa genetički promijenjenim 5HT sustavom, u suprotnosti su sa pretpostavkom da veća bioraspoloživost 5HT dovodi do redukcije tjelesne težine, te traže bolje poznavanje integrativnih mehanizama regulacije energetske homeostaze.Ovim projektom se istražuje uloga individualne razine aktivnosti 5HT sustava u regulaciji unosa i potrošnje energije, korištenjem originalnog životinjskog modela (Wistar-Zagreb 5HT štakor), razvijenog u vlastitom laboratoriju selektivnim parenjem životinja prema aktivnosti perifernog 5HT transportera, ključnog proteina u regulaciji bioraspoloživosti 5HT. Dvije sublinije životinja, 5HT-visoka i 5HT-niska, dobivene genetičkom selekcijom, konstitucijski se razlikuju u homestazi centralnog i perifernog 5HT, što je pokazano neurokemijskim, farmakološkim i bihevioralnim studijama. Jedna od posljedica genetičke selekcije je i značajno povećana tjelesna težina životinja iz 5HT-visoke sublinije. Cilj projekta je otkriti biološku podlogu povezanosti povećane 5HT aktivnosti  i pretilosti kod hiperserotonergičnih životinja, te njezine funkcionalne posljedice. Istraživanja na molekularnoj razini fokusirana su na ekspresiju regulatornih peptida u hipotalamusu i adipocitima, njihove receptore i nizvodne signalne molekule, te transkripcijske faktore uključene u regulaciju adipogeneze i energetske homeostaze općenito. Istraživanja na razini organizma uključuju funkcionalni odgovor životinja na specifične fiziološke izazove - sklonost debljanju pri visoko kaloričnoj prehrani i sposobnost termogeneze pri izlaganju hladnoći.	Pored doprinosa temeljnom znanju u području neuroadipologije, ovaj projekt omogućiti će uspostavu novog životinjskog modela za istraživanje pretilosti.]]></summary_hr><summary_en><![CDATA[The rise in obesity has driven a major interest in the mechanisms maintaining energy homeostasis, a complex physiological process which includes interactions of various central and peripheral regulatory molecules. It is known that serotonin (5HT) - mediated mechanisms play a role in the pathophysiology of obesity, but results from recent studies utilizing genetic perturbations of the serotonin system are often at odds with the historical notion that increased 5HT bioavailability leads to body weight reduction, and highlight the need to better understand integrative mechanisms at work during lifelong alterations in 5HT signaling. This project is aimed to study the impact of constitutionally altered activity of 5HT system on the regulation of hypothalamic-adipose tissue axis that regulates energy balance. For this purpose we plan to use an original animal model, Wistar-Zagreb 5HT rats, developed in our laboratory by the use of selective breding toward extreme activities of peripheral 5HT transporter, a key regulator of 5HT bioavailability. As a result of genetic selection two sublines of the model, high-5HT and low-5HT subline, show constitutional differences in central and peripheral 5HT homeostasis. One of the consequences of genetic selection is also a markedly overweight phenotype of high-5HT animals. We will investigate biological basis of interplay between increased 5HT tone and adiposity in the hyperserotonergic subline, and their functional consequences.Studies at the molecular level will be focused on the expression of adipocyte- and hypothalamic-derived peptides, their receptors and downstream signaling as well as transcriptional factors and cofactors involved in the regulation of adipogenesis and energy homeostasis in general. Studies on the whole body level will include investigations of the functional responses of 5HT sublines to specific physiological challenges -  susceptibility to diet-induced obesity and capability for cold-induced thermogenesis. ]]></summary_en></project><project>
<id>3234</id><title_hr><![CDATA[Sudbina farmaceutika u okolišu i tijekom naprednih postupaka obrade vode]]></title_hr><title_en><![CDATA[Fate of pharmaceuticals in the environment and during advanced wastewater treatment]]></title_en><user_id>1414</user_id><user_firstLast_name>Sandra Babić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-2353</code><acronim><![CDATA[PharmaFate]]></acronim><duration>01.07.2015 - 30.06.2019</duration><status>Završio</status><financ_value>125.223,97 eur</financ_value><scie_area_hr>Prirodne znanosti, Tehničke znanosti, </scie_area_hr><scie_area_en>Natural sciences, Technological sciences, </scie_area_en><scie_field_hr>Kemija, Temeljne tehničke znanosti, </scie_field_hr><scie_field_en>Chemistry, Basic engineering sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet kemijskog inženjerstva i tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Chemical Engineering and Technology]]></institution_en><team_members_id>4216, 900, 13246, 12861, 4391, 4498, 3680, 3775, 3971, 3926, 21142, 13643, </team_members_id><team_members_names><![CDATA[Danijela Ašperger, Lidija Ćurković, Marija Kaštelan-Macan, Davor Ljubas, Dragana Mutavdžić Pavlović, Martina Periša, Mira Petrovic, Irena Škorić, Dragana Vuk, Mirta Zrnčić, Dario Dabić, ĐURĐICA IVANEC ŠIPUŠIĆ, ]]></team_members_names><keywords_hr><![CDATA[farmaceutici, produkti razgradnje, okoliš,  napredni oksidacijski procesi, sol-gel TiO2 filmovi]]></keywords_hr><keywords_en><![CDATA[pharmaceuticals, degradation products, environment, advanced oxidation process, sol-gel TiO2 films]]></keywords_en><summary_hr><![CDATA[Znatan napredak analitičkih metoda u posljednjem desetljeću omogućio je utvrđivanje prisutnosti farmaceutika u svim sferama okoliša. Glavni izvor pojave i otpuštanja farmaceutika u okoliš su postrojenja za obradu otpadnih voda, što uvjetuje potrebu za njihovom nadogradnjom i implementacijom naprednih postupaka obrade voda poput naprednih oksidacijskih procesa (AOP).Kada farmaceutici dođu u okoliš neminovno su izloženi razgradnji. Razgradnja farmaceutika u okolišu ili razgradnja kao posljedica obrade otpadnih voda rezultira produktima sa značajno drugačijim fizikalno-kemijskim i toksičnim svojstvima u odnosu na početnu molekulu, a nerijetko su novonastali spojevi toksičniji od izvornih. Unatoč činjenici da je tisuće farmaceutika odobreno za uporabu, samo je mali postotak njih određivan u okolišu.Glavni ciljevi PharmaFate projekta su (i) razviti nove napredne postupke obrade otpadnih voda na temelju fotokemijskih AOP-a za učinkovito uklanjanje farmaceutika, te (ii) postići bolje razumijevanje sudbine farmaceutika u okolišu ispitivanjem njihove fotolize, hidrolize i sorpcije.U ovom projektu ispitivati će se farmaceutici koji se proizvode u velikim količinama, često se propisuju u medicinskoj praksi, potencijalno su postojani te skloni bioakumulaciji, a ne postoje podatci o njihovoj sudbini u okolišu.Predložene tehnologije obrade otpadnih voda uključuju napredne oksidacijske procese - fotolizu i heterogenu fotokatalizu uz primjenu nanokristaliničnih TiO2 filmova.Razjasnit će se mehanizmi razgradnje i identificirati razgradni produkti primjenom naprednih analitičkih metoda. U konačnici će se procijeniti toksičnost farmaceutika i njihovih razgradnih produkata.Očekivani doprinos projekta je u smislu znanstvenog istraživanja kroz stvaranje novih spoznaja koje će unaprijediti razumijevanje sudbine farmaceutika u okolišu i tijekom obrade voda te unapređenje tehnologija obrade voda čime se postiže socijalna dobrobit očuvanjem okoliša.]]></summary_hr><summary_en><![CDATA[The improvements of analytic methodologies during the last decades have demonstrated the widespread occurrence of pharmaceuticals (PhACs) in all environmental compartments. The main point of collection and subsequent release of PhACs into the environment are wastewater treatment plants (WWTPs), suggesting that their upgrade and implementation of AOPs are required. Once PhACs enter into the environment, partitioning and degradation occur. Degradation of PhACs in the environment or as a result of wastewater treatment can result in degradation products with significantly different physical, chemical and toxic properties even in formation of more toxic compounds. Despite the fact that thousands of PhACs are approved, only a small percentage of them have been studied for presence in the environment. The main objectives of the PharmaFate project are (i) to develop innovative advanced WWTPs based on photochemical AOPs for efficient removal of PhACs and (ii) to achieve an improved understanding of PhACs fate in the environment investigating their photolysis, hydrolysis and sorption.PhACs to be investigated are selected among those identified as high production volume and highly prescribed PhACs, potentially persistent and/or bioaccumulative with no or limited published data on their environmental fate. Proposed treatment technologies include AOPs – photolysis and heterogeneous photocatalysis using nanocrystalline TiO2 based thin films.Degradation mechanisms will be elucidated and degradation products will be identified using advanced analytical methods. Toxicity of PhACs and their degradation products will be assessed.Expected project impacts are in terms of scientific research through creation of new knowledge that will improve our understanding of PhACs fate in the environment and during wastewater treatment, technical improvement of WWTPs and social benefits by preserving the environment. ]]></summary_en></project><project>
<id>3238</id><title_hr><![CDATA[Dizajniranje, sinteza i evaluacija derivata primakina, vorinostata i sorafeniba kao potencijalnih citostatika]]></title_hr><title_en><![CDATA[Design, synthesis and evaluation of novel anticancer agents based on primaquine,  vorinostat and sorafenib scaffolds]]></title_en><user_id>6143</user_id><user_firstLast_name>Branka Zorc</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-1501</code><acronim><![CDATA[PVSderivatives]]></acronim><duration>01.12.2015 - 30.11.2019</duration><status>Završio</status><financ_value>98.838,68 eur</financ_value><scie_area_hr>Prirodne znanosti, Biomedicina i zdravstvo, </scie_area_hr><scie_area_en>Natural sciences, Biomedicine and health sciences, </scie_area_en><scie_field_hr>Farmacija, Kemija, </scie_field_hr><scie_field_en>Pharmaceutical sciences, Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Farmaceutsko-biokemijski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Pharmacy and Biochemistry]]></institution_en><team_members_id>6183, 6538, 6615, 6707, 859, 13658, 21322, </team_members_id><team_members_names><![CDATA[Zrinka Rajić Džolić, Kristina Pavić, Dimitra Hadjipavlou-Litina, Eleni Pontiki, Katja Ester, Schols Dominique, Maja Beus, ]]></team_members_names><keywords_hr><![CDATA[sinteza, primakin, sorafenib, vorinostat, citostatik]]></keywords_hr><keywords_en><![CDATA[synthesis, primaquine, sorafenib, vorinostat, cytostatic]]></keywords_en><summary_hr><![CDATA[Dugoročni cilj projektnog prijedloga je razvoj novih bioaktivnih spojeva koji mogu dovesti do otkrića potencijalnih vodećih spojeva i antitumorskih lijekova. Projekt je usmjeren na dizajniranje, sintezu i biološko vrednovanje novih derivata primakina, vorinostata i sorafeniba. Primakin je antimalarik, dok su vorinostat i sorafenib citostatici.Potencijal da se novi citostatici razviju iz antimalarika postao je očit nakon otkrića da većina antimalarika djeluje citostatski, a čak sedam registriranih antimalarijskih lijekova nalazi se u kliničkim ispitivanjima kao potencijalni citostatici. Naša istraživačka skupina fokusirala se na primakin, antimalarik s kinolinskom strukturom. U nekoliko naših radova opisani su urea i semikarbazidni derivati primakina sa značajnim citostatskim djelovanjem i/ili velikom selektivnosti. Najveću selektivnost prema staničnim linijama MCF-7 i praktički neaktivnost prema ostalim staničnim linijama karcinoma pokazao je hibrid dviju primakin-urea. Na temelju tih rezultata predviđeno je dizajniranje, sinteza i evaluacija novih hibridnih molekula primakina kao potencijalnih citostatika. Prvo će se sintetizirati dvojni lijekovi primakina i vorinostata 3-8. Ti spojevi će se razlikovati po duljini alifatskog lanca i/ili funkcionalnim skupinama: spojevi opće formule 3 su esteri, 4 su karboksilne kiseline, a 6 hidroksamske kiseline kao i sam vorinostat. Potpunom ili djelomičnom redukcijom 4 priredit će se amini 7 i amidi 8. U ovom projektom prijedlogu predviđena je i sinteza amida primakina s derivatima cimetne kiseline 9 te analoga sorafeniba 14 s pirazinski prstenom, s pretpostavkom da će dodatni atom dušika pojačati vezne interakcije na aktivnom mjestu. Da bi odredili utjecaj supstituenata u amidnom ostatku na fizikalno-kemijska svojstva i jačinu djelovanja, planirana je modifikacija tog dijela molekule.Novi spojevi biti će biološki ispitani na citostatsko djelovanje, inhibiciju specifičnih enzima i antioksidativno djelovanje.]]></summary_hr><summary_en><![CDATA[The long-term goal of the proposed research is development of novel compounds with a potential for development to drug lead(s) and anticancer drug(s). The project will focus on rational design, synthesis and biological screening of novel derivatives of three marketed drugs: antimalarial primaquine and two antitumoral drugs vorinostat and sorafenib.The potential for discovery of new anticancer agents among antimalarials was first noted when commonly used antimalarials showed significant anticancer activity (7 of them have reached a clinical stage of development).  We have focused our attention to primaquine, the antimalarial agent with quinoline moiety. In our several papers novel urea and semicarbazide primaquine derivatives with strong antiproliferative activity and/or high selectivity were reported. The highest selectivity against MCF-7 cells and practically no activity against other tested cancer cell lines showed hybrid of two primaquine ureas. Based on these results we intend to design, synthesize and evaluate novel primaquine hybrid compounds as potential anticancer agents. First objective is to design and prepare novel twin drugs based on primaquine and vorinostat scaffolds 3-6. These compounds will differ in length of aliphatic chain and/or functional groups: compounds 3 are esters, 4 are carboxylic acids and 6 hydroxamic acids like vorinostat itself. Reduction of compounds 4 would generate amines 7 and amides 8. Further on, we plan to prepare primaquine amides 9 with substituted cinnamic acid and sorafenib analogs 14 based on pyrazine structure, hoping that additional nitrogen atom would increase the binding interactions. To study how the amide part of the molecule affects the activity and physico-chemical properties of the new pyrazine analogs, the preparation of a number of amides is planned.All new compounds will be screened for cytostatic activity in vitro on several human cancer cell lines, inhibition of specific enzymes and antioxidative activity.]]></summary_en></project><project>
<id>3240</id><title_hr><![CDATA[Izolacija, kvantifikacija i kinetika salivarnih Ap4A, SCCA i TROP2 kod pacijenata s oralnim karcinomom i potencijalno malignim poremećajima]]></title_hr><title_en><![CDATA[Isolation, quantification and kinetics of salivary Ap4A,  SCCA and TROP2 in patients with oral cancer and potentially malignant oral disorders]]></title_en><user_id>13132</user_id><user_firstLast_name>Darko Macan</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-9376</code><acronim><![CDATA[OC Sal TM]]></acronim><duration>01.05.2016 - 30.04.2019</duration><status>Završio</status><financ_value>55.965,28 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Dentalna medicina, Temeljne medicinske znanosti, Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Dental medicine, Basic Medical Sciences, Clinical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Stomatološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Dentistry]]></institution_en><team_members_id>6958, 13181, 13213, </team_members_id><team_members_names><![CDATA[Ivan Salarić, Davor Brajdić, Ivan Zajc, ]]></team_members_names><keywords_hr><![CDATA[Rak usne šupljine, Tumorski markeri, Slina, Kromatografija, Tekućinska visokog učinka, Usna šupljina]]></keywords_hr><keywords_en><![CDATA[Oral cancer, Tumor Markers, Saliva, Chromatography, High Pressure Liquid, Mouth]]></keywords_en><summary_hr><![CDATA[Stanice oralnog karcinoma (OC) proizvode biokemijske substance, tumorske markere, u različitom omjeru  nego maligno neralterirane stanice, mjerljive u tkivima i/ili tjelesnim tekućinama.  Slina, radi svoje pristupačnosti, neposrednosti i neinvazivnog uzorkovanja, predstavlja idealno sredstvo za mjerenje tumorskih markera. Cilj ovog projektnog prijedloga jest izolirati, kvantificirati, objasniti ulogu i opisati kinetiku diadenozin tetrafosfata (Ap4a), „Squamous Cell Carcinoma povezanog antigena“ (SCCA), „Trophoblast cell surface antigena“ (TROP2) u zdravih pojedinaca te pacijanata s potencijalno malignim poremećajima (PMOD) i OC-om. Postoje brojna istraživanja na temu tumorskih markera OC-a, međutim, zadovoljavajuća specifičnost i senzitivnost još nije dosegnuta. Za izolaciju i kvantifikaciju gore navedenih markera razvit će se Liqiud chromatography-ion trap-mass spectrometry, Multiple Reaction Monitoring metoda (LC-IT-MS,MRM). Prema našim saznanjima, ova metoda dosad nije korištena za izolaciju i kvantifikaciju navedenih markera. Ap4a i TROP2 dosada nisu izolirani iz sline. Konačan cilj istraživanja jest razviti tumor-specifični test sa zadovoljavajućom senzitivnošću i specifičnošću te dinamički mjeriti markere, prije i nakon kirurškog zahvata, nakon radioterapije, nakon kemoterapije, jednu i dvije godine nakon inicijalne dijagnoze. Također, kao namjeravamo odrediti cirkadijalni ritam svakog pojedinačnog markera kako bi isključili potencijalne „confoundere“ kao što su utjecaj određene prehrambene namirnice ili pušenja ispitanika.  Tumor-specifični test OC-a, omogučio bi raniju dijagnozu OC-a, potencijalno i prije kliničkih simptoma, podizanje rate peto-godišnjeg preživljenja, omogučio raniju dijagnozu recidiva i/ili novih primarnih tumora te osigurao bolju kvalitetu života nakon liječenja. ]]></summary_hr><summary_en><![CDATA[Oral cancer (OC) tumor cells produce biochemical substances, tumor markers, differed from healthy individulals in expression or quantitative ratio, detectable in tissues and/or body fluids. Saliva, bacause of its accessibility, proximity and noninvasive approach, presents an ideal tool for the research of oral cancer tumor markers. The aim of this study will be to isolate, quantify, analyze the role and describe the kinetics of diadenosine tetraphophate (Ap4A), Squamous Cell Carcinoma associated Antigen (SCCA), Trophoblast cell surface antigen (TROP2) in patients with OC, potentially malignant disorders (PMOD) and age and sex matched control group with a clear medical history.There are number of studies published on OC tumor markers isolated mostly in serum, however the satisfactory specificity and sensitivity still hasn’t been reached. Liqiud chromatography-ion trap-mass spectrometry, Multiple Reaction Monitoring method (LC-IT-MS, MRM) will be developed to isolate and quantify the above mentioned tumor markers. To our knowledge, this method hasn&#39;t yet been used to quantify the above mentioned salivary tumor markers. Ap4A and TROP2 have never been isolated from saliva. Our goal is to develop a tumor-specific test with a satisfactory statistical sensitivity and specificity and dynamically measure the levels of tumor markers, before and immediately after therapy - surgery/radiotherapy/chemotherapy or their combination, and during regular follow-up one and two years after surgery. As another novelty, we will dtermine the markers circadian rhythm. A OC tumor specific test, with satisfactory sensitivity and specificity, would enable earlier OC diagnosis, possibly before the clinical appearance, raise the survival rate of OC patients, enable early diagnosis of recurrence and/or new primary tumors and ensure better post-treatment life-quality. ]]></summary_en></project><project>
<id>3248</id><title_hr><![CDATA[Uspostavljanje međukulturnih poveznica kroz prijevode dječje književnosti: tekst, kontekst, strategije]]></title_hr><title_en><![CDATA[Building Intercultural Bridges through Children’s Literature Translations: Texts, Contexts and Strategies]]></title_en><user_id>4856</user_id><user_firstLast_name>Smiljana Narančić Kovač </user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2014-09</proposal_call><code>UIP-2014-09-9823</code><acronim><![CDATA[BIBRICH]]></acronim><duration>01.09.2015 - 31.08.2018</duration><status>Završio</status><financ_value>57.442,43 eur</financ_value><scie_area_hr>Humanističke znanosti, Društvene znanosti, </scie_area_hr><scie_area_en>Humanities, Social sciences, </scie_area_en><scie_field_hr>Filologija, Obrazovne znanosti, </scie_field_hr><scie_field_en>Philology, Educational sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Učiteljski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Teacher Education]]></institution_en><team_members_id>5533, 2998, 5121, 5469, 4987, 5328, 5970, 5081, 13123, 18943, </team_members_id><team_members_names><![CDATA[Berislav Majhut, Tihomir Engler, Katarina Aladrović Slovaček, Sanja Lovrić Kralj, Ivana Milković, Corinna Jerkin, Snježana Veselica-Majhut, Marija Andraka, Iris Šmidt Pelajić, Nada Kujundžić, ]]></team_members_names><keywords_hr><![CDATA[hrvatska dječja književnost, prijevodne strategije, pripovjedna proza, 20. stoljeće, međukulturni prijenos, kanon, diskurs, ukriženi tekst]]></keywords_hr><keywords_en><![CDATA[Croatian children&#39;s literature, translation strategies, narrative fiction, 20th century, intercultural transfer, canon, discourse, crossover text]]></keywords_en><summary_hr><![CDATA[Cilj je predloženoga projekta prikazati i objasniti ulogu i status prevedenih djela u korpusu hrvatske dječje književnosti, opisati trendove i tendencije u povijesnoj perspektivi te otkriti i protumačiti upotrijebljene prijevodne strategije. Projekt je usmjeren na prijevode pripovjedne proze na hrvatski i iz hrvatskoga na druge jezike tijekom dvadesetoga stoljeća.Međunarodna istraživanja dječje književnosti u novije se vrijeme u znatnoj mjeri okreću k poredbenoj dječjoj književnosti, fokusirajući se na analizu prijevoda, međukulturni prijenos i kontakte među jezicima i kulturama. U tome se podudaraju s prijevodnim studijima u širem smislu. Nakana je uspostaviti skupinu istraživača koja bi razvila takvo područje istraživanja u hrvatskome kontekstu, i koja će postaviti istraživačke standarde i prilagoditi primjerenu metodologiju specifičnostima opisanoga predmeta istraživanja.U planu je sastavljanje bibliografije prijevoda dječjih knjiga i ukriženih tekstova (crossover texts), tj. djela ujedno namijenjenih dječjem i odraslom čitateljstvu. Podatci će se analizirati i tumačiti s obzirom na polazišne i posredne jezike pojedinih prijevoda, povijesne trendove, izbor knjiga u odnosu na kanon dječje književnosti, nakladničke prakse i druge aspekte. Nadalje, odabrani primjeri prijevoda analizirat će se kako bi se utvrdile prijevodne strategije na različitim razinama diskursa. Razmotriti će se jezični, pripovjedni, kulturni i međukulturni aspekti s ciljem otkrivanja prijevodnih normi i strategija odomaćivanja (domestikacije). Hrvatskim će se djelima prevedenima na druge jezike posvetiti posebna pozornost.Rezultati će se analizirati i interpretirati kako bi se objasnile prijevodne tendencije, trendovi i dinamika književnih suodnosa tijekom dvadesetoga stoljeća iz hrvatske perspektive, kao i u međunarodnome kontekstu.Predloženi će projekt pripremiti temelj za dalji razvoj opisanoga područja istraživanja i za buduću širu međunarodnu suradnju.   ]]></summary_hr><summary_en><![CDATA[The proposed project aims to depict and explain the role and status of translated books within Croatian children’s literature, to describe trends and tendencies in a historical perspective, and to establish and interpret adopted translation strategies. The project focuses on translations of narrative fiction into and from Croatian over a span of a hundred years, i.e. in the 20th century. International scholarship in the field of children’s literature has recently turned towards comparative children’s literature, focusing on translation, intercultural transfer and contacts among languages and cultures. In so doing, it intersects with recent trends in translation studies in general. The proposed project aims to establish a team of researchers who would develop such an area of research in Croatia. The goal is to set research standards and fine-tune appropriate methodology.The researchers intend to assemble a bibliography of translated children’s books and crossover texts. Records will be analysed and interpreted with respect to the source and intermediary languages represented, historical trends, book selection relative to the canon of children’s literature, publishing practices and other aspects. Next, a selection of published books will be analysed for translation strategies at several levels of discourse. The researchers will address linguistic, narrative, cultural and intercultural aspects, and focus on uncovering translation norms and domestication strategies. Croatian books translated into other languages will receive special attention.Finally, the results will be analysed and interpreted to explain the documented translation flows, trends, and the dynamics of literary relationships in the 20th century, from the Croatian perspective and in the international context. The proposed project will present a sound foundation for further development of the established area of research and of a wider international cooperation in the future. ]]></summary_en></project><project>
<id>3251</id><title_hr><![CDATA[Električko nabijanje međupovršina na granici čvrsta faza/vodena otopina elektrolita]]></title_hr><title_en><![CDATA[Electrical charging of solid/aqueous electrolyte interfaces]]></title_en><user_id>244</user_id><user_firstLast_name>Tajana Preočanin</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-6972</code><acronim><![CDATA[SAQUINT]]></acronim><duration>01.06.2015 - 31.05.2019</duration><status>Završio</status><financ_value>114.539,78 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>836, 4764, 4782, 1015, 234, 5334, 22756, 24520, </team_members_id><team_members_names><![CDATA[Danijel Namjesnik, Damir Iveković, Sandra Čičić, Jasmina Salopek, Davor Kovačević, Josip Požar, Antun Barisic, Tin Klačić, ]]></team_members_names><keywords_hr><![CDATA[električni međupovršinski sloj, površinske reakcije, površinski potencijal, metalni oksidi, polielektroliti, višeslojevi, kompleksiranje, nanočestice ]]></keywords_hr><keywords_en><![CDATA[electrical interfatial layer, surface reaction, surface potential, metal oxide, polyelectrolyites,multilayers, complexation, nanoparticles]]></keywords_en><summary_hr><![CDATA[Cilj je predloženog projekta istražiti procese koji se zbivaju na međupovršini čvrsta tvar/tekućina u svrhu boljeg razumijevanja interakcije površine mineralnih faza s molekulama vode, otopljenim ionima i složenim makromolekulama. Nove eksperimentalne metode omogućavaju karakterizaciju pojedinih kristalnih ploha te će se ispitati utjecaj strukture površine na nastajanje električkog međupovršinskog sloja. Za određivanje površinskog potencijala na 0-plohi pojedinih kristalnih ploha koristit će se monokristalne elektrode koje su po prvi put konstruirane u našem laboratoriju. Naime, upravo površinski potencijal na 0-plohi definira broj i vrstu površinskih specija na određenoj plohi, a time i ravnotežno stanje. Kombiniranjem podataka dobivenim mjerenjem površinskog potencijala na 0-plohi i elektrokinetičkog potencijala nastojat će se objasniti ravnotežni procesi koji se zbivaju na granici faza. Zanimljivu klasu površinskih reakcija čine procesi uzastopne naizmjenične adsorpcije polielektrolita suprotnog naboja na okside metala i polumetala. Navedeni procesi bit će istraženi u sklopu predloženog projekta. Dobiveni rezultati će se usporediti s rezultatima kompleksiranja polielektrolita u otopini. Naglasak u istraživanju bit će na specifičnom utjecaju protuiona na reakcije dvaju suprotno nabijenih polielektrolita. U konačnici rezultati dobiveni za pojedine plohe će se primijeniti na koloidne i nano čestice čija se površina sastoji od različitih kristalnih ploha. Interes za istraživanjem spomenutih nanostruktura i polielektrolita povezan je sa brojnim mogućnostima njihove primjene u industriji, odnosno razumijevanju uloge prirodnih polielektrolita i proteina u biološkim procesima. U svrhu izvođenja projekta koristit će se različite eksperimentalne metode, a za bolje razumijevanje procesa koje se zbivaju na međupovršinama i dobivanja kvantitativnog opisa specijacije svih vrsta koje sudjeluju u površinskim reakcijama, bit će razvijeni i odgovarajući teorijski modeli.]]></summary_hr><summary_en><![CDATA[In order to contribute to the understanding of basic interactions between the mineral phases and water molecules, ions and macromolecules we propose the investigations of processes at solid/liquid interfaces. Particular attention will be paid on a role of water, simple counterions and surface structure in formation of electrical interfacial layer. The single crystal electrode, device developed and constructed recently in our laboratory, will be used for determination of inner surface potential of specific crystal planes. Inner surface potential affects directly the state of ionic species bound to defined surface plane and is thus essential parameter governing interfacial equilibrium. The role of interfacial water in interfacial equilibrium will be analyzed by considering its behavior at inert surfaces but also at metal oxide surfaces. Finally, the results obtained for the particular crystal planes will be applied for colloids and nanoparticles exhibiting different crystal planes to the liquid medium. A special case of interfaces are polyelectrolytes at the metal oxide surface. Therefore, such interfaces and their correlation with the behaviour of polyelectrolytes in solution will be also extensively studied in the frame of the proposed project. The reason lies in fundamental interest to understand their properties in relation with the role of natural polyelectrolytes and proteins in biological processes, as well as in industrial applications. The latter are not limited to polyelectrolytes in solution, but include also the polyelectrolyte (or interpolyelectrolyte) complexes and multilayers. The formation of multilayers of polyelectrolytes at solid surfaces, as well as interpolyelectrolyte interactions in solution, will be examined. Special emphasis will be given on specific ionic effects. Predominantly the experimental methods will be applied, and theoretical tools will be developed in order to better understand behavior, reactivity and equilibrium at interfaces.]]></summary_en></project><project>
<id>3265</id><title_hr><![CDATA[Električni transport u staklima i staklo-keramici]]></title_hr><title_en><![CDATA[Electrical transport in glasses and glass-ceramics]]></title_en><user_id>4869</user_id><user_firstLast_name>Andrea Moguš-Milanković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-5863</code><acronim><![CDATA[EL-Trass-Ceram]]></acronim><duration>15.06.2015 - 14.06.2018</duration><status>Završio</status><financ_value>99.542,11 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>3297, 3302, 3421, 13648, 13669, 13670, 21288, </team_members_id><team_members_names><![CDATA[Ana Šantić, Kristina  Sklepić, Luka Pavić, Grégory TRICOT, Petr Mosner, Ladislav Koudelka, Juraj Nikolić, ]]></team_members_names><keywords_hr><![CDATA[Električni prijenos, staklo, staklo-keramika, elektronsko-ionska vodljivost, efekt &#39;&#39;miješanih&#39;&#39; staklotvoraca]]></keywords_hr><keywords_en><![CDATA[Electrical transport, glass, glass-ceramics, mixed ionic-electronic conductivity, mixed glass former effect]]></keywords_en><summary_hr><![CDATA[Izraženi zahtjevi suvremenih tehnologija za novim materijalima sa specifičnim svojstvima otvaraju velike mogućnosti u istraživanju stakala i staklo-keramike. Priprava novih stakala i staklo-keramika posebnih svojstava, istraživanje odnosa sastava stakla, strukture, električnih i termičkih svojstava posebno je važno za razumijevanje procesa koji se odvijaju u tim materijalima. Cilj je predloženog istraživanja priprava novih više-komponentnih fosfatnih stakala te određivanje odnosa između dvije osnovne vrste nositelja naboja, iona i elektrona, prisutnih u odabranim staklima i staklo-keramikama. Predloženi je projekt podijeljen na tri osnovna, međusobno povezana, koraka. 1. U prvom će se dijelu istraživati mehanizmi vodljivosti u fosfatnim staklima koja pokazuju „miješanu“ elektronsko-ionsku vodljivost. 2. Drugi dio uključuje istraživanje utjecaja „miješanih“ staklotvoraca na električne procese kod fosfatnih stakala.  3. U trećem će se dijelu istraživati utjecaj kontrolirane kristalizacije na električni prijenos u odabranim modelnim sustavima iz koraka 1 i 2. Nastajanje kristalnih zrna u staklenoj matrici može promijeniti električnu vodljivost i dielektična svojstva stakla. Temeljna je ideja projekta sustavno istraživanje koje će pridonijeti razumijevanju dinamike prijenosa naboja (iona i elektrona) u staklima i staklo-keramici s različitim udjelom kristalnosti (od potpuno amorfnih do potpuno kristaliziranih). Osnovni je cilj odrediti pokazuju li uvijek ionsko-elektronska stakla i stakla koja sadrže više staklotvoraca, efekt ionsko-elektronske vodljivosti odnosno efekt „miješanih“ staklotvoraca što predstavlja univerzalno obilježje.  Međudjelovanje staklotvoraca i modifikatora mreže te nastajanje veza među njima osnovni su čimbenici koji utječu na električna svojstva stakala. Osim što je istraživanje mehanizama vodljivosti u odabranim sustavima važno s akademskog gledišta, odabrani sustavi pokazuju široke mogućnosti u primjeni kao novi elektroliti.]]></summary_hr><summary_en><![CDATA[Considerable demands of modern technology for new materials with specific properties have raised many possibilities for the investigation of glasses and glass-ceramics. Preparation of new glass and glass-ceramics with characteristic properties and the investigation of relationships among compositions, structure, electrical and thermal properties are important for understanding the mechanisms involved in these materials. The objectives of the proposed research is to prepare novel multi-compositional phosphate-based glasses, determine the correlation among both types of charge carriers, ions and electrons, present in proposed systems. In order to accomplish this, the proposed project is divided into three main interrelated steps. 1. First part will be focused on the conduction mechanisms in phosphate-based glasses that exhibit mixed electronic-ionic conduction. 2. Second part includes study of the influence of the mixed glass former effect on electrical processes in phosphate-based glasses. 3. Third part involves study of the influence of controlled crystallization on electrical transport in selected model glasses from steps 1 and 2. The formation of crystalline grains  in a glass matrix can substantially change electrical conductivity and dielectric properties of glass. The idea is to perform systematic studies for understanding the charge transport (ion and electron) dynamics in glasses and glass-ceramics with different crystallinity (from fully amorphous to fully crystallized). The main aim is to determine the universality of the mixed electronic-ionic and mixed glass former effects in proposed glasses. The interactions between glass formers and modifiers, the formation of bonds among them are essential factors that influence the electrical properties of glasses. Beyond the connection to the central theme of conduction mechanism important from academic point of view, the selected systems are all associated with their multiple applications as advanced electrolytes.]]></summary_en></project><project>
<id>3266</id><title_hr><![CDATA[Akrobacije molekulskih kristala - termoodskočni materijali za novu generaciju aktuatora]]></title_hr><title_en><![CDATA[Acrobatics of molecular crystals – thermosalient materials for new generation of actuators]]></title_en><user_id>13189</user_id><user_firstLast_name>Željko Skoko</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-7506</code><acronim><![CDATA[AKROBATOO MATER]]></acronim><duration>01.07.2015 - 30.06.2018</duration><status>Završio</status><financ_value>93.512,51 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, Kemija, </scie_field_hr><scie_field_en>Physics, Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>12971, 13347, 4933, </team_members_id><team_members_names><![CDATA[Lidija Androš, Pance Naumov, Vito Despoja, ]]></team_members_names><keywords_hr><![CDATA[termoodskočni efekt, aktuatori, strukturna analiza, rendgenska difrakcija, kvantnomehaničko modeliranje]]></keywords_hr><keywords_en><![CDATA[thermosalient effect, actuators, structure analysis, XRD, DFT calculations]]></keywords_en><summary_hr><![CDATA[Ciljano dizajniranje novih aktuatorskih materijala, koji su u stanju pružiti odgovor na vanjsku pobudu (toplinsku ili svjetlosnu) u obliku brzog, revezibilnog i kontroliranog mehaničkog kretanja trenutno predvodi istraživanja u znanosti o materijalima. Među takvim materijalima, nekoliko slučajno otkrivenih primjera kristala koji skaču za vrijeme grijanja, do daljina nekoliko tisuća puta većih od njihovih dimenzija u vremenu kraćem od 1 ms, pružaju impresivan prikaz pretvorbe toplinske energije u mehanički rad. Takvi termoodskočni (eng. thermosalient) kristali su biomimetički, nepolimerni samo-aktuatori par excellance. Ipak, zbog ekskluzivnosti ovog fenomena, i također zbog izuzetne složenosti analitičke metodologije za njegovu karakterizaciju, razlozi koji izazivaju ovu kolosalnu samo-aktuaciju ostaju nerazjašnjeni. Unutar projekta, odredit će se razlog postojanja termoodskočnog efekta u odabranim sustavima organskih molekulskih kristala (trans, trans, anti, trans, trans perhidropiren, L-piroglutamska kiselina te N’-2-propiliden-4-hidroski-benzohidrazid) koji su već poznati u literaturi, ali su još nerazjašnjeni. Nadalje, istraživanja će se proširiti na skupinu spojeva dobivenu odabranim i pažljivim modificiranjem spojeva za koje je efekt prethodno ustanovljen. Za očekivati je da će termoodskočni efekt biti izuzetno osjetljiv na suptilne promjene u kemijskom sastavu stoga će se omogućiti određivanje uvjeta za modeliranje novih materijala s termoodskočnim svojstvima. S ciljem elucidacije termoodskočnog fenomena, ovaj projekt predstavlja prvi sustavni pokušaj određivanje međuigre između termodinamičkih, kinematičkih, strukturnih i makroskopskih faktora termoodskočnog efekta pomoću difrakcijskih (XRD), mikroskopskih (hot-stage), spektroskopskih (FTIR, UV/VIS) i termičkih (DTA/DSC/TG) tehnika. Ispitivani sustavi također će se izučavati kvantomehaničkim modeliranjem (DFT). ]]></summary_hr><summary_en><![CDATA[Targeted design of new actuating materials which are capable of fast, reversible and controllable mechanical motion in response to external stimuli (thermal or light) is at the frontier of the contemporary materials science research. Among these, the few serendipitously discovered examples of crystals that suddenly jump while heated, to distances several thousand times larger than their own dimension in less than 1 ms, provide the most impressive display of the conversion of thermal energy into mechanical work. These thermosalient crystals are biomimetic, nonpolymeric self-actuators par excellence. Yet, due to exclusivity of the phenomenon, but also due to the complexity of analytical methods for its characterization, reasons behind this colossal self-actuation remain unexplained. Within this project, reasons behind the thermosalient effect in chosen systems of organic molecular crystals (trans,trans,anti,trans,trans perhydropyrene, L-pyroglutamic acid and N&#39;-2-propylidene-4-hydroxy-benzohydrazide), already reported in the literature – but unexplained, will be revealed. Furthermore, research will broaden to include a group of compounds obtained by careful and planned modification of the compounds in which the effect has already been observed. It is to be expected that the thermosalient effect is very sensitive to the subtle changes in the chemical composition so this will enable determination of necessary chemical/structural parameters so as to arouse the thermosalient effect in the system. With the aim of final elucidation of the thermosalient phenomenon, this project represents first systematic attempt to disentangle the interplay between the thermodynamic, kinematic, structural and macroscopic factors that drive the thermosalient effect by employing various diffraction (XRD), microscopic (hot stage), spectroscopic, (FTIR, UV/VIS) and thermal (DTA/DSC/TG) techniques. Systems under study will also be investigated by the means of quantomechanical modeling (DFT). ]]></summary_en></project><project>
<id>3277</id><title_hr><![CDATA[Prirodno stanište klinički značajnih Acinetobacter baumannii]]></title_hr><title_en><![CDATA[Natural habitat of clinically important Acinetobacter baumannii]]></title_en><user_id>419</user_id><user_firstLast_name>Jasna Hrenović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-5656</code><acronim><![CDATA[NATURACI]]></acronim><duration>01.09.2015 - 31.10.2019</duration><status>Završio</status><financ_value>132.617,96 eur</financ_value><scie_area_hr>Prirodne znanosti, Biomedicina i zdravstvo, Biotehničke znanosti, Tehničke znanosti, </scie_area_hr><scie_area_en>Natural sciences, Biomedicine and health sciences, Biotechnical sciences, Technological sciences, </scie_area_en><scie_field_hr>Javno zdravstvo i zdravstvena zaštita, Geologija, Kemija, Biologija, Kemijsko inženjerstvo, Kliničke medicinske znanosti, Biotehnologija, </scie_field_hr><scie_field_en>Public health and health services, Geology, Chemistry, Biology, Chemical engineering, Clinical sciences, Biotechnology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>405, 1404, 12655, 586, 2669, 749, 565, 486, 18952, </team_members_id><team_members_names><![CDATA[Tomislav Ivanković, Darko Tibljaš, Marin Ganjto, Ivana Goić Barišić, Goran Durn, Ana Kovačić, Nevenka Rajić, Jelena Milenkovic, BLAŽENKA  HUNJAK, ]]></team_members_names><keywords_hr><![CDATA[Acinetobacter baumannii, Bakterije, Ekologija, Otpadna voda, Remedijacija, Tlo, Zeoliti]]></keywords_hr><keywords_en><![CDATA[Acinetobacter baumannii, Bacteria, Ecology, Remediation, Soli, Wastewater, Zeolites]]></keywords_en><summary_hr><![CDATA[Bakterija Acinetobacter baumannii je oportunistički patogen odgovoran za bolničke infekcije u imunokompromitiranih bolesnika, čija pojavnost dramatično raste tijekom zadnjeg desetljeća u Hrvatskoj i svijetu. Infekcije bakterijom A. baumannii se teško liječe zbog njihovih brojnih urođenih i stečenih mehanizama odgovornih za višestruku antibiotsku rezistenciju (multidrug-resistance; MDR), sposobnosti stvaranja biofilma, te dugotrajnog preživljavanja u bolnicama. Smatra se da su epidemije infekcija bakterijom A. baumannii uzrokovane isključivo kontaminacijom i prijenosom u bolničkom okruženju. MDR A. baumannii su nađene u bolničkim otpadnim vodama, ali ovakvi podaci nedostaju u Hrvatskoj. Do danas nije definirana pojavnost klinički važnih Acinetobacter spp. u prirodi niti njihov potencijal da prelaze u i/ili iz bolničkog okruženja. Potrebno je definirati prirodno stanište klinički važnih MDR A. baumannii. Postoji potreba za širim praćenjem te epidemiološkim studijama istraživanja utjecaja ljudskog otpada na rasprostranjivanje MDR A. baumannii. Cilj predloženog projekta je izolirati vijabilne MDR A. baumannii iz okolišnih uzoraka otpadne vode i tla. Okolišni izolati bit će genotipizirani te će biti određena njihova filogenetska srodnost s ljudskim izolatima kao i geni odgovorni za njihovu antibiotsku rezistenciju. Bit će određen i utjecaj ekoloških čimbenika na preživljavanje okolišnih izolata A. baumannii. Nadalje, istražit će se međudjelovanje okolišnih izolata A. baumannii i zeolita kao okolišno prihvatljivih dezinficijensa. Bit će razvijene metode i alternativni dezinficijensi na bazi prirodnih materijala za remedijaciju otpadnih voda i tla koja sadrže A. baumannii. Rezultati predloženog projekta će definirati prirodno stanište A. baumannii, te predložiti načine za smanjenje njihovog broja u zagađenom okolišu.]]></summary_hr><summary_en><![CDATA[Acinetobacter baumannii is an opportunistic pathogen responsible for nosocomial infections in immunocompromised patients, which emergence in hospital acquired infections increase dramatically over the last decade, both in Croatia and worldwide. Infections with A. baumannii are difficult to treat due to its ability to express multiple intrinsic and acquired mechanisms responsible for multidrug-resistance (MDR) to antibiotics, biofilm formation, and long-term persistence in hospitals. Outbreaks of A. baumannii infections are considered to be caused exclusively by contamination and transmission in hospital environment. MDR A. baumannii were detected in hospital wastewater, but such data are lacking in Croatia. The prevalence of clinically important Acinetobacter spp. in nature and their potential to migrate into and/or out of the hospital environments are undefined to date. The natural habitats of clinically important MDR A. baumannii remain to be defined. Larger screening and epidemiological studies should be performed to investigate the impact of human waste on the spread of MDR A. baumannii. The objective of the proposed project is to isolate viable MDR A. baumannii from the environmental samples of wastewater and soils. The environmental isolates will be genotyped and their phylogenetic relation to human isolates will be determined, as well as the profiles and genes responsible for their antibiotic resistance. The influence of ecological factors on the survival of environmental isolates of A. baumannii will be investigated. Interaction of environmental isolates of A. baumannii and zeolites as environmental friendly disinfectants will be studied. Methods and alternative disinfectants based on natural materials for the remediation of wastewater and soils containing A. baumannii will be developed. The findings of the proposed project will define the natural habitat of A. baumannii, and propose ways to reduce their numbers in contaminated environment.]]></summary_en></project><project>
<id>3286</id><title_hr><![CDATA[Komparativna i funkcionalna genomika fitoplazmi– emergentnih biljnih patogena u Hrvatskoj]]></title_hr><title_en><![CDATA[Comparative and functional genomics of phytoplasmas–emerging plant pathogens in Croatia ]]></title_en><user_id>12617</user_id><user_firstLast_name>Martina Šeruga Musić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2014-09</proposal_call><code>UIP-2014-09-9744</code><acronim><![CDATA[GenoPhyto]]></acronim><duration>01.07.2015 - 31.10.2018</duration><status>Završio</status><financ_value>73.992,97 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, Biotehnologija, </scie_field_hr><scie_field_en>Agriculture, Biotechnology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>11295, 12676, 12691, 12712, 12835, 13554, </team_members_id><team_members_names><![CDATA[Dijana Škorić, Foissac Xavier, Ivana Križanac, Jelena Plavec, Željko Budinšćak, Saskia Hogenhout, ]]></team_members_names><keywords_hr><![CDATA[bakterije, epidemiologija, dijagnostika, patogenost, filogenomika]]></keywords_hr><keywords_en><![CDATA[bacteria, epidemiology, diagnostics, pathogenicity, phylogenomics]]></keywords_en><summary_hr><![CDATA[Fitoplazme (rod ‘Candidatus Phytoplasma’) su bakterije bez stanične stijenke razreda Mollicutes - uzročnici značajnih bolesti biljaka u čitavom svijetu. Složenog su i jedinstvenog životnog ciklusa jer parazitiraju unutar stanica biljnog floema kao i stanica kukaca i trebaju oba domaćina za rasprostranjivanje u prirodi. Imaju male genome bogate ponavljajućim sljedovima reducirane u osnovnim metaboličkim putovima. Nije ih moguće uzgojiti u čistoj kulturi in vitro. Unatoč tome, do sada su sekvencirana 4 fitoplazmatska genoma uz nekolicinu nepotpunih. Era genomike donijela je značajna saznanja o funkcioniranju fitoplazmi no mehanizmi patogenosti još nisu razjašnjeni. Prisutnost fitoplazmi u Hrvatskoj dokazana je na simptomatičnim trsovima vinove loze krajem 90.-tih. Broj novih fitoplazmatskih vrsta, kukaca-vektora kao i ugroženih biljnih vrsta i dalje raste, s najbolje karakteriziranim patosistemima na vinovoj lozi i voćkama. Glavni cilj ovog projekta je sekvenciranje fitoplazme ‘Ca. P. solani’, najrasprostranjenije u Hrvatskoj, te generiranje i analiza nacrta ili potpuno sastavljenog genoma. Dobiveni rezultati ukazali bi na potencijalne efektore - faktore virulencije te druge molekule uključene u interakcije s domaćinima i prilagodbe okolišnim uvjetima. Nadalje, bili bi genotipizirani novi i već dostupni izolati MLST (multilocus sequence typing) analizom konstitutivnih te specifičnih varijabilnih gena. Zadaća projekta je i razvoj novog oruđa za genotipizaciju sa svrhom poboljšane dijagnostike i izrade molekularno-epidemioloških studija. Funkcionalne studije bile bi usmjerene na varijabilne membranske proteine odgovorne za interakcije s kukcima-vektorima. Ovo bi bio prvi projekt sekvenciranja nekog genoma bakterijskog patogena u Hrvatskoj. Ovim uspostavnim projektom i osnivanjem istraživačke grupe otvorilo bi se novo područje molekularne biljne patologije i genomike, slabo zastupljeno u hrvatskoj znanosti, a dobiveni rezultati postavili bi osnove za buduća istraživanja.]]></summary_hr><summary_en><![CDATA[Phytoplasmas (genus &#39;Candidatus Phytoplasma&#39;) are wall-less bacteria from the class Mollicutes that affect numerous plant species worldwide causing significant economic losses. They have a unique life-style inhabiting plant phloem and insect cells and needing both hosts for survival in nature. Their genomes are repeat-rich yet relatively small and reduced missing many basic metabolic pathways. Phytoplasma axenic cultivation is still challenging. Nevertheless, 4 phytoplasma genomes have been sequenced and annotated with several genome drafts also available. However, the understanding of all mechanisms underlying phytoplasma pathogenicity is far from complete. First molecular evidence for the phytoplasma presence in Croatia has been given in late 1990’s on grapevine. Since then, the number of discovered phytoplasma species, insect vectors and affected plant hosts is rising with grapevine and fruit trees’ phytoplasma pathosystems being well characterized. The main objective of this project would be sequencing of ‘Ca. P. solani’, the most widespread phytoplasma in Croatia, with generation and comparative analysis of genome draft or fully assembled genome. Obtained results would give new data on candidate virulence effectors and other factors involved in interactions with hosts and adaptation to different environments. Another goal would be genotyping of new and already available isolates by multilocus sequence typing (MLST) analyses of house-keeping and specific variable genes. New genotyping tools for improved diagnostics and molecular epidemiology studies with implications in risk assessment would also be developed. Functional studies would focus on surface variable membrane proteins involved in interactions with insect hosts and transmissibility. Moreover, this would be the first sequencing project of a bacterial plant pathogen genome in Croatia. The establishment of this project would open a new field of molecular plant pathology and genomics in Croatian science.]]></summary_en></project><project>
<id>3288</id><title_hr><![CDATA[poremećena vazorelaksacija i endotelno-leukocitna interakcija (ELI) u razvoju aterosklerotskih lezija]]></title_hr><title_en><![CDATA[Impaired Vasorelaxation and Endothelial-Leukocyte Interaction (ELI) in Development of Atherosclerotic Lesions]]></title_en><user_id>477</user_id><user_firstLast_name>Ines Drenjančević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-6380</code><acronim><![CDATA[V-ELI Athero]]></acronim><duration>01.10.2015 - 30.09.2019</duration><status>Završio</status><financ_value>130.332,23 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, Clinical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Medicinski fakultet Osijek]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Medicine]]></institution_en><team_members_id>722, 488, 594, 1263, 415, 2779, 482, 548, 487, 1053, 518, 24322, </team_members_id><team_members_names><![CDATA[Kristina Selthofer-Relatić, Martina Mihalj, Anita Ćosić, Mirela Baus Loncar, Ivana Tartaro Bujak, Anita  Horvatić, Zrinka Mihaljević, IVANA GRIZELJ, Ana Čavka, Maro Bujak, Dubravka Mihaljević, Nataša Kozina, ]]></team_members_names><keywords_hr><![CDATA[vazorelaksacija, visoko slana dijeta, endotelno-leukocitna interakcija, angiotenzin II, aterosklerotske lezije, TFF3-/- miševi]]></keywords_hr><keywords_en><![CDATA[vasorelaxation, high salt diet, endothelial-leukocyte interaction, angiotensin II, atherosclerotic lesion, TFF3-/-mice]]></keywords_en><summary_hr><![CDATA[Povećan unos soli hranom potiskuje renin-angiotensin sustav (RAS) i poznat je čimbenik rizika za hipertenziju i kardiovaskularne bolesti. Štoviše, slana dijeta utječe na endotelnu aktivaciju kod aterogenog izobličenja stijenke žile, potičući endotelno-leukocitnu interakciju kod APOE-/- miševa. Oksidativni stres je u podlozi upalnog procesa kod stvaranja aterosklerotskog plaka. Naše prijašnje studije pokazale su da je supresija RAS-a  slanom hranom u podlozi poremećene o endotelu-ovisne diilatacije zbog povećanog oksisdativnog stresa i promjene u stvaranju vazoaktivnih metabolita arahidonske kiseline. Infuzija niskih doza angiotenzina II vodi oporavku relaksacije. Međutim, uloga RAS-a u razvoju rane ateroskleroze se tek nazire. U ovom projektu ispitat ćemo hipotezu da oporavak RAS-a (infuzijom niskih doza angiotenzina II smanjuje endotelno-leukocitnu interakciju (ELI) poništavajući oksidativni stres i proizvodnju proinflamatornih metabolita arahidonske kiseline. Koristit ćemo normotenzivne Sprague Dawley štakore kojima se potiskuje RAS unosom soli i TFF3-/- transgenične miševe. TFF3-/- miševi su potpuna novost u ovom istraživačkom pristupu i obećavajući novi model za proučavanje aterosklerotskih lezija i sinteze proinflamatornih citokina, zbog svojeg protektivnog fenotipa i povoljnog omjera ?6/?-3 masnih kiselina i izmijenjenog metabolizma arahidonske kiseline. Cilj 1: rasvijetliti efekt oporavka RAS-a na mehanizme protokom posredovane dilatacije u životinja na slanoj dijeti. CIlj 2: odrediti utjecaj oporavka RAS-a na interakciju endotelnih stanica i leukocita. Rezultati bi mogli pružiti dokaze za promjenu paradigme o RAS-u kao uvijek štetnom za cirkulaciju i poduprijeti novu paradigmu da je noramlno modulirani RAS ključan u prevenciji stvaranja aterosklerotskih lezija]]></summary_hr><summary_en><![CDATA[High salt (HS) diet suppresses the renin-angiotensin system (RAS) and is known risk factor for hypertension and cardiovascular diseases. Furthermore, HS diet has a direct effect on endothelial activation under atherogenic shear stress, promoting the endothelial-leukocyte interactions in ApoE-/-mice.Oxidative stress underlies inflammatory processes in atherosclerotic plaque formation. Our previous studies demonstrated that RAS suppression by HS diet underlies impaired endothelium-dependant vasorelaxation due to increased oxidative stress and due to the shift in the production of vasoreactive metabolites of arachidonic acid. Infusion of subpressor doses of angiotensin II restored normal vasorelaxation. However, involvement of the RAS in development of early atherosclerosis is only emerging. In this project we will test the hypothesis that restoration of the RAS (by infusions of subpressor doses of angiotensin II) decreases endothelial activation and abolishes endothelial-leukocyte interactions (ELI) by eliminating oxidative stress and the production of proinflammatory metabolites of arachidonic acid. We will use normotensive Sprague-Dawley (SD) rats that exhibit suppression of the RAS with HS intake and in TFF3-/- transgenic mice. TFF3-/- mice are complete novelty in this research approach, and promising new model for studying the atherosclerotic lesion formation and proinflammatory cytokine synthesis, due to their protective phenotype of favorable ratio of ?6/?-3 fatty acids and modified metabolism of arachidonic acid. Aim 1: to elucidate the effect of RAS restoration on the mechanisms of flow-mediated responses in animals on HS diet. Aim 2: to determine the effect of RAS restoration on endothelial cells and leukocytes interactions. The results may provide evidence for the shift in the paradigm that the RAS is always detrimental to circulation and support the new paradigm of crucial role of normally modulated RAS in prevention of atherosclerotic lesion formation]]></summary_en></project><project>
<id>3290</id><title_hr><![CDATA[Primjena mikrosimulacijskih modela u analizi poreza i socijalnih naknada u Hrvatskoj]]></title_hr><title_en><![CDATA[Application of Microsimulation Models in the Analysis of Taxes and Social Benefits in Croatia]]></title_en><user_id>842</user_id><user_firstLast_name>Ivica Urban</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2014-09</proposal_call><code>UIP-2014-09-4096</code><acronim><![CDATA[AMMATSBC]]></acronim><duration>01.09.2015 - 31.08.2018</duration><status>Završio</status><financ_value>34.861,07 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, </scie_field_hr><scie_field_en>Economy, </scie_field_en><institution_hr><![CDATA[Institut za javne financije]]></institution_hr><institution_en><![CDATA[Institute of Public Finance]]></institution_en><team_members_id>12574, 4472, 12420, 12417, 21291, </team_members_id><team_members_names><![CDATA[Slavko Bezeredi, Saša Jakšić, Chrysa  Leventi, Holly  Sutherland, Martina Pezer, ]]></team_members_names><keywords_hr><![CDATA[mikrosimulacije, modeli, porezi, socijalne naknade, EUROMOD, reforma, ponuda rada, zaposlenost, raspodjela dohotka, siromaštvo]]></keywords_hr><keywords_en><![CDATA[microsimulation, models, taxes, social benefits, EUROMOD, reform, labour supply, employment, income distribution, poverty]]></keywords_en><summary_hr><![CDATA[Mikrosimulacijski model poreza i socijalnih naknada (MSMPN) za svakog pojedinca iz skupa mikropodataka izračunava odgovarajuće iznose poreznih obveza i socijalnih naknada na koje osoba ima pravo. MSMPN omogućuje ex ante pregled učinaka promjena u sustavu poreza i socijalnih naknada i zbog toga je iznimno vrijedan alat u analizi i planiranju reforme.Za razliku od ostalih zemalja EU-a, gdje je uobičajena upotreba MSMPN-a, u Hrvatskoj je razvoj mikrosimulacijskih modela još uvijek u začetku.Zbog toga je svrha ovog projekta primijeniti mikrosimulacijske modele hrvatskih poreza i socijalnih naknada u analizama za potrebe vođenja javne politike i u akademskim analizama. Primjenom mikrosimulacijskih modela u analizi aktualnih ekonomsko-političkih problema ovaj projekt će pokazati korisnost mikrosimulacijskih modela te privući pozornost čelnika javne uprave i akademskih istraživača u Hrvatskoj.Istraživanje ima tri cilja:(1) Razviti mikrosimulacijski model hrvatskih poreza i naknada – miCROmod:miCROmod će biti konvencionalni statički aritmetički MSMPN koji simulira doprinose za socijalno osiguranje, porez na dohodak, zajamčenu minimalnu naknadu, doplatak za djecu, roditeljske naknade i naknadu za nezaposlene. Osim toga, razvit će se: (a) dodatak za jedinice lokalne vlasti, kojim se modeliraju porezi i socijalne naknade u Gradu Zagrebu, i (b) bihevioralni dodatak, koji će simulirati utjecaj promjena instrumenata poreza i socijalnih naknada na ponudu rada i na bruto plaće.(2) Upotrijebiti miCROmod i EUROMOD u analizi poreza i socijalnih naknada:miCROmod i EUROMOD (MSMPN za sve zemlje EU) koristit će se u analizi učinka raznih reformi na nejednakost u raspodjeli dohotka, stope siromaštva i poticaje za rad, a to su reforme: (a) Potpora za djecu, (b) Poreza na dohodak, (c) Instrumenata za povećanje isplativosti rada i (d) Lokalnih socijalnih naknada.(3) Predstaviti djelovanje mikrosimulacijskih modela čelnicima javne uprave i istraživačima.]]></summary_hr><summary_en><![CDATA[Microsimulation model of taxes and social benefits (MSMTBs) calculates for each individual person from a set of microdata the corresponding amounts of taxes payable and social benefits receivable. MSMTBs allow ex ante review of the effects of changes in tax-benefit system. Therefore, they are particularly valuable in the reform analysis and planning.Unlike in other EU countries, where the use of MSMTBs is widespread, the development of MSMTBs in Croatia is still in its infancy.Therefore, the purpose of this project is to apply microsimulation models of Croatian taxes and benefits in public policy and academic analysis. By application of MSMTBs in analysing contemporary economic and policy problems, the project will demonstrate the usefulness of these models, and attract the attention of public administration leaders (PALs) and researchers in Croatia.The research project has three objectives:(1) Develop the microsimulation model of Croatian taxes and benefits – miCROmod:miCROmod will be a conventional static arithmetic MSMTB that simulates social security contributions, personal income tax, guaranteed minimum income, child benefit, parental benefits and unemployment benefit. miCROmod will also include: (a) a local government supplement, modelling taxes and benefits in the City of Zagreb and (b) a behavioural supplement, simulating the impact of changes of tax-benefit instruments on the labour supply and gross wages.(2) Employ miCROmod and EUROMOD in the analysis of tax-benefit reform scenarios:miCROmod and EUROMOD (a comprehensive MSMTB for the EU) will then be used in the the analysis of the effect of a number of tax-benefit reforms on income inequality, poverty rates and incentives to work. These reforms cover: (a) Child benefits, (b) Personal income tax (c) In-work policies, and (d) Local social benefits.(3) Present the performance of miCROmod and EUROMOD to PALs and researchers.]]></summary_en></project><project>
<id>3295</id><title_hr><![CDATA[Geometrijska, ergodička i topološka analiza nisko-dimenzionalnih dinamičkih sustava]]></title_hr><title_en><![CDATA[Geometric, Ergodic and Topological Analysis of Low-dimensional Dynamical Systems]]></title_en><user_id>5838</user_id><user_firstLast_name>Siniša Slijepčević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-2285</code><acronim><![CDATA[GETDYN]]></acronim><duration>01.05.2015 - 30.04.2019</duration><status>Završio</status><financ_value>97.285,82 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>1391, 3200, 2932, 3100, 5225, 2870, 3173, 5810, 2929, 3773, 2709, 6413, 17706, 22480, 20035, </team_members_id><team_members_names><![CDATA[Vesna Županović, Pavao Mardešić, Goran Radunović, Lana Horvat Dmitrović, Marina Ninčević, Sonja Štimac, Darko Žubrinić, Braslav Rabar, Davor  Dragičević, Domagoj Vlah, Maja Resman, Sibe Mardešić, Ana Anušić, Milena Vulević, Kristijan Kilassa Kvaternik, ]]></team_members_names><keywords_hr><![CDATA[Dinamički sustavi, Fraktalna dimenzija, Fraktalna zeta funkcija, Potkovno preslikavanje, Stabilnost, Bifurkacija, Navier-Stokesova jednadžba]]></keywords_hr><keywords_en><![CDATA[Dynamical systems, Fractal dimension, Fractal zeta function, Horseshoe map, Stability, Bifurcation, Navier-Stokes Equation]]></keywords_en><summary_hr><![CDATA[Naš znanstveni rad će se fokusirati na unapređenje i dalji razvoj aktualnih uzbudljivih i važnih rezultata članova tima, objavljenih u vodećim međunarodnim časopisima (u zadnjih 5 godina, 18 Q1 i 9 Q2 članaka). Recentni rezultati uključuju: Rješenje Ingramove hipoteze te bolje razumijevanje atraktora Henonovog te Loci preslikavanja, koji su među najproučavanijim dinamičkim sustavima (S. Štimac); Razvoj novih definicija fraktalnih invarijanti, te karakterizacija graničnih ciklusa u terminima fraktalne dimenzije (V. Županović); Razumijevanje dinamike poznatih sustava koji uključuju vučeni Frenkel-Kontorova model, te Navier-Stokesovu jednadžbu, primjenjujući ergodsko-teorijske te slične alate (S. Slijepčević), te Uvođenje, etabliranje i razvoj novih fraktalnih zeta funkcija kao važan alat u dinamičkim sustavima (D. Žubrinić).Uz znanstveni razvoj, naši ciljevi uključuju osnivanje novih plodnih istraživačkih suradnji na međunarodnom nivou, kao i nastavak postojećih produktivnih i aktivnih suradnji s više od 15 međunarodnih sveučilišta. Također ćemo osigurati da naše istraživanje ima veću vidljivost i utjecaj, te ćemo tražiti fizikalne i inžinjerske primjene i suradnju. Konačno, namjeravamo nastaviti kao i do sad, s 5 studenata koji su doktorirali u posljednje 3 godine, često u suradnji s vodećim međunarodnim sveučilištima i stručnjacima (Dijon, California Riverside), te s post-doktorantima koji nastavljaju utjecajna istraživanja na međunarodnom nivou.Fokus našeg projekta je također dalji razvoj našeg nedavno osnovanog Centra za nelinearnu dinamiku (www.math.hr/cnd), kao regionalnog centra za istraživanje iz dinamičkih sustava, jednog od ključnih područja čiste i primijenjene matematike.]]></summary_hr><summary_en><![CDATA[Our scientific work will focus on advancement and further development of recent exciting and important results of the team members, published in the leading international journals (in the last 5 years 18 Q1 and 9 Q2 articles). The recent results include: Solution of the Ingram’s hypothesis and better understanding of attractors of Henon’s and Lozi map, one of the most studied dynamical systems (S. Štimac); Developing of new definitions of fractal invariants, and characterizations of limit cycles in terms of fractal dimension (V. Županović); Understanding of dynamics of well-known systems including the driven Frenkel-Kontorova model and the Navier-Stokes equation by applying ergodic-theoretical and related tools (S. Slijepčević), and Introducing, establishing and developing new fractal zeta functions as an important tool in dynamical systems (D. Žubrinić). In addition to scientific advancement, our general objectives include establishing new fruitful research collaborations at the international level, as well as continuing existing productive and active collaboration with over 15 leading international universities. We will also make sure our research is more visible and with more impact, and will look for physical and engineering applications and collaborations. Finally, we plan to continue our track record of 5 students completing their PhD’s in the last three years, often in collaboration with the leading international universities and experts (Dijon, California Riverside), and that postdocs continue impactful research at the international level. Focus of our project is also further development of our recently founded Centre for nonlinear dynamics (www.math.hr/cnd), as a regional centre for resarch in dynamical systems, as one of the key areas of pure and applied mathematics.]]></summary_en></project><project>
<id>3298</id><title_hr><![CDATA[ Determinante uspješnosti poslovanja poduzeća]]></title_hr><title_en><![CDATA[Determinants of firms&#39; success and failure]]></title_en><user_id>11292</user_id><user_firstLast_name>Maja Pervan</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2014-09</proposal_call><code>UIP-2014-09-1745</code><acronim><![CDATA[DETSUCCFAIL]]></acronim><duration>01.10.2015 - 30.09.2018</duration><status>Završio</status><financ_value>20.731,42 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, </scie_field_hr><scie_field_en>Economy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Ekonomski fakultet]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Economics, Business and Tourism]]></institution_en><team_members_id>11294, 11316, 11319, </team_members_id><team_members_names><![CDATA[Ivica Pervan, Marijana Ćurak, Tomislava Pavić Kramarić, ]]></team_members_names><keywords_hr><![CDATA[Uspješnost poslovanja poduzeća, profitabilnost, prerađivačka industrija, bankrot, dinamička panel analiza, multipla regresija, logistička regresija]]></keywords_hr><keywords_en><![CDATA[Firms&#39; success, profitability, manufacturing industry, bankruptcy, dynamic panel analysis, multiple regression, logistic regression  ]]></keywords_en><summary_hr><![CDATA[Poslovni uspjeh poduzeća predstavlja važnu, aktualnu i neiscrpnu temu istraživanja koja izaziva interes brojnih znanstvenika i stručnjaka iz prakse. U sadašnjem kontekstu tržišne liberalizacije, rastuće konkurencije, tehnoloških inovacija i ukidanja trgovinskih barijera, istraživanje determinanti koje su relevantne i značajne u objašnjavanju poslovnog uspjeha poduzeća postaje od krucijalne važnosti.Uvažavajući prethodno, prvi cilj ovog istraživanja je kreirati model koji će identificirati čimbenike koji određuju uspjeh poduzeća. U usporedbi s postojećim empirijskim istraživanjima, kreirani model će biti unaprijeđen na nekoliko načina: (1) uz zahvaćanje dinamičkog aspekta poslovnog uspjeha poduzeća, model će istodobno analizirati determinante na razini poduzeća, industrije i makro-okruženja; (2) razmatrat će nelinearne efekte pojedinih determinanti profitabilnosti, kao i primjenu različitih mjera performansi (tradicionalnih i indikatora performansi novčanog toka). Formulacija takvog modela ne postoji u hrvatskoj prerađivačkoj industriji kao ni u zemljama središnje i istočne Europe. Osim identifikacije determinanti uspješnosti poslovanja poduzeća, namjera se kreirati i model koji će biti u mogućnosti prognozirati vjerojatnost bankrota poduzeća. Uz tradicionalne mjere performansi, u istraživanju će se koristiti i Operating Cash Flow Capacity što predstavlja originalnu ideju i unaprjeđenje dosadašnjih modela budući da ova varijabla može biti pouzdanija od neto dobitka s obzirom na latentni problem manipulacija dobitkom. Prema našim spoznajama, niti jedno drugo istraživanje nije koristilo ovu mjeru performansi za predviđanje bankrota poduzeća. Dodatno, u ovom istraživanju će se koristiti i pristup s tri ili više grupa statusa neuspjeha poduzeća. Za ovaj dio istraživanja primijenit će se logistička regresija kao i nova, sofisticirana ekonometrijska metoda, neuronske mreže.]]></summary_hr><summary_en><![CDATA[The issue of firm business success is an important, actual and inexhaustible subject that draws attention of many scientific researchers and practitioners. In the present context of market liberalization, increased competition, technological innovation and vanishing trade barriers, the investigation of the determinants that are relevant and significant in explaining firms’ business success becomes crucial.Having previous in mind, the first goal of this research proposal is to create a model that will identify factors that determine firms&#39; success. When compared with the previous empirical research, the designed model will be improved in several ways: (1) it will encompass the dynamic aspect of firms’ success while simultaneously analysing firm-level, industry-level and macroeconomic determinants of profitability; (2) it will consider nonlinear effects of profitability determinants and different measures of performance (traditional and cash flow performance indicators). Formulation of such a model doesn’t exist, not only in the Croatian manufacturing sector, but even in the Central and Eastern Europe.Aside from identifying the drivers of firms’ success, we also intend to determine the factors that explain firms’ financial failure i.e. we will create a model that will be able to predict the probability of firms’ bankruptcy. Besides using traditional firms’ performance indicators we will also use an Operating Cash Flow Capacity, what represents original idea and improvement of modelling since this variable could be more reliable than net income regarding the latent problem of earnings management. As far as we know, no other research before used this measure of performance for the prediction of a firms’ failure (bankruptcy). Additionally, we will use an approach with three or more classes of firm failure status. For this part of the research, the logistic regression as well as a novel and sophisticated econometric method i.e. neural networks will be applied.]]></summary_en></project><project>
<id>3302</id><title_hr><![CDATA[Centromerna genomika beskralješnjaka]]></title_hr><title_en><![CDATA[Invertebrate centromere genomics]]></title_en><user_id>506</user_id><user_firstLast_name>Miroslav Plohl</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-3183</code><acronim><![CDATA[CENGEN]]></acronim><duration>01.10.2015 - 30.11.2020</duration><status>Završio</status><financ_value>132.324,64 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>332, 12849, 2778, 5779, 1030, 508, 21387, 21386, 22650, </team_members_id><team_members_names><![CDATA[Brankica Mravinac, Fernando Azorin, Eva Šatović, Nevenka Meštrović, CASTAGNONE Philippe, Barbara Mantovani, Evelin Despot Slade, Tena Gržan, Monika Tunjić, ]]></team_members_names><keywords_hr><![CDATA[centromera, CenH3, satelitna DNA, ponovljena DNA, evolucija, kornjaši, oblići, školjkaši]]></keywords_hr><keywords_en><![CDATA[centromere, CenH3, satellite DNA, repetitive DNA, evolution, beetles, nematodes, molluscs]]></keywords_en><summary_hr><![CDATA[Centromera je domena esencijalna za razdvajanje kromosoma u staničnim diobama. Razumijevanje centromerne strukture i funkcije od velikog je značaja u biologiji, a značajno je i s biomedicinskog stajališta. Funkcionalne centromere obilježene su centromerno specifičnim proteinom sličnim histonu H3 (CenH3). Centromerni identitet određuju i genomski i epigenetički mehanizmi, koji podstiču brzu koevoluciju i vrsnu specifičnost proteina CenH3 i njemu pridruženih sekvenci DNA bez narušavanja centromerne funkcije. Složenost i varijabilnost centromernog područja uzrok su još uvijek fragmentalne percepcije centromerne genomike, koja je razrađena samo na nekoliko biljnih i životinjskih modelnih organizama. Sekvencirani genomi modelnih organizama beskralješnjacima s različitom konstitucijom centromernih regija nedavno su postali dostupni. Kornjaši roda Tribolium imaju centromere uklopljene duboko u pericentromerni heterokromatin bogat satelitnim DNA, oblići korijenovih kvržica roda Meloidogyne imaju holocentrične kromosome, dok školjkaš Crassostrea gigas ima nejednoliku razdiobu satelitnih DNA u centromerama. Glavni cilj ovog projektnog prijedloga je identificirati CenH3 i njima pridružene sekvence DNA, kao i njihove nefunkcionalne varijante kako bi se istražila genomika različito organiziranih centromera. Nadalje, biti će ispitani organizacijski i evolucijski obrasci proteina CenH3 i centromernih sekvenci DNA. Strategija istraživanja kombinira identifikaciju CenH3, kromatinsku imunoprecipitaciju (ChIP) s antitijelima na CenH3, fluorescencijsku hibridizaciju in situ (FISH), imunofuorescencijsku lokalizaciju in situ (IF) i bioinformatičke metode. Takav integrativni pristup će ponuditi informacije o ovim funkcionalno značajnim dijelovima koji najčešće nedostaju u sekvenciranim genomima i unaprijediti naše razumijevanje sinergije i koevolucije centromernih sekvenci DNA i proteinskih komponenata. ]]></summary_hr><summary_en><![CDATA[The centromere is a domain essential for chromosomal segregation in cell divisions. Understanding its structure and function is of the highest importance in biology, and also crucial from biomedical point of view. Functional centromeres are marked by centromere-specific histone H3-like proteins (CenH3). Centromere identity involves both genomic and epigenetic mechanisms, favoring rapid co-evolution and species specificity of CenH3 and associated DNA sequences without impairing the function. Complexity and variations make perception of centromere genomics still fragmental and worked out only in a few most common plant and animal model systems. Among invertebrates, sequenced genomes of model organisms with diverse constitution of centromeric regions became recently available. Tribolium beetles have centromeres embedded deeply into the satellite DNA-rich pericentromeric heterochromatin, Meloidogyne root-knot nematodes have holocentric chromosomes, while the mollusk Crassostrea gigas lacks uniform distribution of satellite DNAs in centromeres. The main goal of this research proposal is to identify CenH3 and CenH3-associated DNA sequences as well as their non-functional genomic counterparts in order to explore genomics of differently organized centromeres. In addition, organizational and evolutional aspects of CenH3 and centromeric DNA sequences will be addressed. The research strategy will combine CenH3 identification, chromatin immunoprecipitation (ChIP)-based assays using anti-CenH3 antibodies, fluorescence in situ hybridization (FISH), immunofluorescence in situ localization (IF) and the bioinformatics pipeline. Such integrative approach will help filling the gaps in functionally essential regions of sequenced genomes and will forward our understanding of the synergy and coevolution between DNA sequences and protein components in the centromeres.  ]]></summary_en></project><project>
<id>3303</id><title_hr><![CDATA[Razumjevanje puta ulaska Adenovirusa tipa 26 u stanicu: način poboljšanja vektora za vakcinaciju]]></title_hr><title_en><![CDATA[Understanding cell entry pathway of Adenovirus type 26: way of improving vaccine vectors]]></title_en><user_id>12819</user_id><user_firstLast_name>Dragomira Majhen</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2014-09</proposal_call><code>UIP-2014-09-3912</code><acronim><![CDATA[AdVEntPathVac]]></acronim><duration>01.09.2015 - 31.08.2018</duration><status>Završio</status><financ_value>66.361,40 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>13083, 4830, 3972, </team_members_id><team_members_names><![CDATA[Jelena Knežević, Mladen Krajačić, Jelena Ruščić, ]]></team_members_names><keywords_hr><![CDATA[adenovirus tip 26, vektor, vakcinacija, unutarstanično putovanje, TLR, urođeni imunološki odgovor]]></keywords_hr><keywords_en><![CDATA[adenovirus type 26, vector, vaccination, intracellular trafficking, TLR, innate immune response]]></keywords_en><summary_hr><![CDATA[Adenovirusni  vektori imaju potencijalno translacijsku i komercijalnu vrijednost, a trenutno se istražuju kao vektori za prijenos DNA i vakcinu. Imunogeničnost adenovirusa tipa 26 (AdV26) značajno se razlikuje od drugih adenovirusnih vektora  što bi mu moglo dati  prednost pred ostalim adenovirusnim serotipovima u razvoju vakcina. Trenutno nema studija koje opisuju ulazak AdV26 u stanicu ističući potrebu za istraživanjem načina na koji AdV 26 inficira stanicu. U skladu s tim, ciljevi ovog projekta su istraživanje AdV26 receptora, vezanja i internalizacije AdV26 u ciljnu stanicu, AdV26 unutarstaničnog putovanja te urođenog imunološkog odgovora potaknutog infekcijom AdV26. Naši znanstveni ciljevi su novi i inovativni te usmjereni prema stvaranju novih znanja i rješenja kliničkih problema, a predložene metode koriste trenutno stanje tehnike. Ovim projektom uvodimo novo istraživanje u području adenovirusnih  vektora što našu grupu stavlja na uzbudljiv i vodeći rub istraživanja adenovirusa. Uspostavom ovog istraživanjanaša bi grupa postala dio mreže industrijsko-akademskog partnerstva u bazičnim i translacijskim istraživanjima adenovirusa u Europi što bi nam omogućilo ostvarivanje daljnjih suradnji i povećalo mogućnost dobivanja novih financiranja u budućnosti. Vjerujemo da će nova znanja koja će proizaći iz našeg istraživanja imati značajan utjecaj u području istraživanja  te biti od koristi kako akademskoj zajednici tako i industriji. Naša grupa, čije se osnivanje predlaže u ovom projektu, jedina je istraživačka grupa koja proučava bazičnu biologiju adenovirusnih vektora u Hrvatskoj čime se osigurava nastavak aktivnog istraživanja adenovirusa u Institutu Ruđer Bošković.]]></summary_hr><summary_en><![CDATA[Adenovirus (AdV) based vectors have potential translational and commercial values and are currently studied as vectors for DNA transfer and vaccination. Adenovirus type 26 (AdV26) has fundamental differences in immunogenicity from other AdV vectors, which might give it advantage over other AdV serotypes in vaccine vector development. To the best of our knowledge there are no reports describing AdV26 entry pathway underlining the need for studying infection pathway used by AdV26. Accordingly, the main objectives of this study are investigating AdV26 receptor usage, binding, internalization, intracellular trafficking and AdV26 mediated induction of innate immune response. Our scientific objectives are novel, innovative and designed to generate new knowledge and opportunities for therapeutic advances in areas of unmet clinical need. Our technical objectives use state-of-the-art, span academic and industrial specialties creating cross sector knowledge and long lasting inter-sectoral benefits. With this project we will introduce new line of AdV vector research in our group that would position us on the exciting and cutting edge of AdV research. Herewith we will become part of long lasting network of industrial–academic partnership in adenovirus basic and translational research across Europe granting lasting collaborations and increasing possibilities for obtaining new grants in the future. We believe that outputs of our research will have considerable impact on the field through gaining new knowledge from which both academia and industry will benefit. Our group, whose establishment is proposed in this project, is the only research group that studies basic biology of adenovirus vectors in Croatia and this grant proposal represents continuation of active adenovirus research in Ruđer Bošković Institute.]]></summary_en></project><project>
<id>3304</id><title_hr><![CDATA[Morski plankton kao alat za procjenu klimatskog i antropogenog utjecaja na morski ekosustav]]></title_hr><title_en><![CDATA[Marine plankton as a tool for assessment of climate and anthropogenic influence on the marine ecosystem]]></title_en><user_id>2662</user_id><user_firstLast_name>Živana Ninčević Gladan</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-3606</code><acronim><![CDATA[MARIPLAN]]></acronim><duration>01.06.2015 - 30.11.2019</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, Fizika, Geologija, Kemija, </scie_field_hr><scie_field_en>Biology, Physics, Geology, Chemistry, </scie_field_en><institution_hr><![CDATA[Institut za oceanografiju i ribarstvo]]></institution_hr><institution_en><![CDATA[Institute of Oceanography and Fisheries]]></institution_en><team_members_id>6243, 207, 5789, 5840, 5284, 6017, 2761, 3007, 2983, 3031, 3130, 5818, 6043, 6741, 5979, 6799, </team_members_id><team_members_names><![CDATA[Olja Vidjak, Natalia Bojanić, Sanda Skejić, Mia Bužančić, Grozdan Kušpilić, Slavica Matijević, Branka Grbec, Gordana Beg Paklar, Tomislav Džoić, Žarko Kovač, Ivana Ujević, Jasna Arapov, Jelena Mandić, Jelena Lušić, Darko Koracin, Danijela Bogner, ]]></team_members_names><keywords_hr><![CDATA[morski plankton, antropogeni utjecaj, klimatske promjene, ekološko modeliranje, ciste dinoflagelata, Jadransko more]]></keywords_hr><keywords_en><![CDATA[marine plankton, anthropogenic influence, climate change, ecological modelling, dinoflagellate cysts, Adriatic Sea]]></keywords_en><summary_hr><![CDATA[Zbog vrlo duge obalne linije, morske orijentacije i iznimne gospodarske važnosti morskih resursa u Republici Hrvatskoj, razumijevanje utjecaja suvremenih globalnih megatrendova kao što su klimatske promjene i rastući antropogeni pritisci na morski okoliš trenutno predstavljaju ključni problem. Ovaj je projektni prijedlog usmjeren na promjene u zajednicama morskog planktona zbog njegovog brzog odgovora na promjene u okolišu. Istraživačke aktivnosti organizirane su kroz dva usko povezana istraživačka modula: Modul 1 - Antropogeni utjecaj na morski okoliš i Modul 2 - Istraživanja posljedica klimatskih promjena na planktonske zajednice. Aktivnosti vezane uz Modul 1 odvijati će se kombiniranjem podataka o prostornoj raspodjeli, intenzitetu i posljedicama antropogenih utjecaja s raspoloživim dugoročnim nizovima podataka o gustoći i strukturi planktonskih populacija u priobalnim vodama i ekološkim i taksonomskim istraživanjima u prijelaznim vodama (Projektni zadatak 1.1,), istraživanjem taloženja i bioakumulacije po zdravlje opasnih organskih spojeva i teških metala u morskom ekosustavu (Projektni zadatak 1.2) i kvantificiranjem disperzije čestica korištenjem lagranžijanskog modela (Projektni zadatak 1.3.). Utjecaj klimatskih promjena na morski plankton će se istraživati utvrđivanjem odnosa između klime i populacija pomoću dugoročnih nizova oceanografskih i planktonskih podataka koristeći inovativne statističke metode (Projektni zadatak 2.1) i kroz praćenje klimatskih promjena putem identifikacije i kronologije bioloških vremenskih kapsula kao što su dinoflagelatne ciste (Zadatak 2.2., Pilot projekt Lingulodinium polyedrum). Predloženi projekt predstavlja inovativan pristup u proučavanju klimatski i ekološki uvjetovanih promjena morskih planktonskih populacija. Očekujemo da će rezultati projekta doprinijeti uspostavi trajnih rješenja usmjerenih na  praćenje zdravlja mora. ]]></summary_hr><summary_en><![CDATA[Due to the long coastal line, marine orientation and economic importance of sea-based resources in the Croatia, understanding how recent global megatrends such as changing climate and growing anthropogenic influence affect the marine environment is currently the key issue. This project proposal is targeting changes in the marine plankton due to fast response to environment changes. The research activities are organized in two highly interconnected research modules: (Module 1) Anthropogenic influence on the marine environment and (Module 2) Investigations of climate changes on ecological processes and plankton communities.Module 1 related activities are to be studied by combining data on spatial distribution, intensity and consequences of human impacts with available time-series data on abundances and population structure of plankton communities in coastal waters, and by taxonomic research in transitional waters (Task 1.1.), by determining deposition and bioaccumulation of health-threatening organic compounds and heavy metal contaminants in the marine ecosystem (Task 1.2.) and by quantifying dispersion of particles through the use of Lagrangian models (Task 1.3.). Climate change impacts on marine plankton will be investigated by identifying climate-population connections using long-term oceanographic and plankton data series through the innovative synthesis techniques (Task 2.1) and by tracing the climate related changes through identification and chronology of biological time capsules such as dinoflagellate cysts (Task 2.2., Pilot project Lingulodinium polyedrum). The proposed project represents a novel approach to the study of climatologically and environmentally driven changes to the marine plankton populations. The results are expected to make contribution towards the long-term program of ecological monitoring that is needed to track the sea health, address the current climate issues, and maximize the potential to recommend permanent solutions.]]></summary_en></project><project>
<id>3309</id><title_hr><![CDATA[Oscilatorna dinamika citoskeleta]]></title_hr><title_en><![CDATA[Oscillatory dynamics of the cytoskeleton]]></title_en><user_id>11207</user_id><user_firstLast_name>Iva Tolić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-4753</code><acronim><![CDATA[OSCITON]]></acronim><duration>01.09.2015 - 30.09.2019</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, Fizika, </scie_field_hr><scie_field_en>Biology, Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>7715, 6276, 4004, 12534, 12533, 13281, 13288, 21341, 25284, </team_members_id><team_members_names><![CDATA[Igor Weber, Nenad Pavin, Matko Glunčić, Maja Marinović, Marko Šoštar, Maja Novak, Marcel Prelogović, Mihaela Jagrić, Lucija Mijanović, ]]></team_members_names><keywords_hr><![CDATA[citoskelet, mikrotubuli, motorni proteini, diobeno vreteno, stanično kretanje, Rho GTPaze, mikroskopija, teorijsko modeliranje]]></keywords_hr><keywords_en><![CDATA[cytoskeleton, microtubules, motor proteins, mitotic spindle, cell migration, Rho GTPases, microscopy, theoretical modeling]]></keywords_en><summary_hr><![CDATA[Oscilacije u citoskeletu važne su za biologiju stanice kao sredstvo prostorne i vremenske regulacije stanične organizacije, diobe stanica i njihove pokretljivosti. U projektu OSCITON istraživat ćemo dva oscilatorna procesa. Kao prvo, proučavat ćemo mehanizam oscilacija kinetohora koje pokreću mikrotubuli tijekom mitoze, te utjecaj kinezina-8 na taj proces. Te oscilacije stvaraju sile napetosti između sestrinskih kinetohora, bez kojih stanica ne može proći kontrolnu točku u metafazi. Oscilacije ćemo proučavati uz pomoć naprednih tehnika svjetlosne mikroskopije u HeLa stanicama u kojima ćemo eksprimirati tubulin-GFP i kinetohorni protein mRFP-Cenp-B, te smanjiti ili pojačati ekspresiju kinezina-8. Da bismo proučavali sile koje djeluju na kinetohore, promijenit ćemo ravnotežu sila laserskom mikrodisekcijom mikrotubula vezanih na kinetohore. Paralelno s eksperimentima razvit ćemo teorijski model, koji će omogućiti interpretaciju utjecaja kinezina-8 na oscilacije. Kao drugo, proučavat ćemo oscilatornu repolarizaciju stanica Dictyostelium tijekom njihovog nasumičnog gibanja. Pretpostavljamo da kompeticija efektorskih kompleksa DGAP1/korteksilin i Scar/Wave za zajednički aktivator Rac1 igra središnju ulogu u repolarizaciji. Kako bismo testirali ovu hipotezu, koristit ćemo novu fluorescentnu sondu za aktivni Rac1, stanice s poremećenom ravnotežom efektorskih kompleksa, te stanice sa reduciranom funkcionalnošću proteina Rac1. Eksperimentalno i teorijski ćemo proučavati dinamiku Rac1, njegovih efektora, te F-aktina u stanicama divljeg tipa i mutiranih sojeva. Ovaj će interdisciplinarni projekt omogućiti optimalno korištenje resursa i okupiti znanstvenike s iskustvom u širokom rasponu disciplina od molekularne i stanične biologije, biokemije, mikroskopije do teorijske biofizike. Udruživanjem svih istraživača iz područja dinamike citoskeleta u Hrvatskoj okupit ćemo tim koji će igrati važnu ulogu u tom području istraživanja na međunarodnoj razini.]]></summary_hr><summary_en><![CDATA[Oscillations in the cytoskeleton are of general importance in cell biology as a means of spatial and temporal regulation of the cellular organization, cell division and motility. The project OSCITON focuses on two oscillatory processes. First, we will investigate the mechanism of microtubule-driven kinetochore oscillations during mitosis, and the role of kinesin-8 motors in this process. These oscillations generate tension between sister kinetochores, which is required to pass the spindle checkpoint. We will use HeLa cells expressing tubulin-GFP and mRFP-CENP-B, a kinetochore protein, in combination with advanced light microscopy and depletion or overexpression of kinesin-8 motors. To study the forces acting on kinetochores, we will perturb the force balance by performing laser microsurgery of the microtubules attached to kinetochores. The experiments will be accompanied by the development of a theoretical model, which will allow us to explore the role of kinesin-8 in the oscillations. Second, we will study the oscillatory repolarization of Dictyostelium cells during random migration. We propose that the competition of DGAP1/cortexillin and SCAR/Wave complexes for the common activator Rac1 plays a central role in this process. To test this hypothesis, we will use a novel fluorescent probe for active Rac1 GTPases, generate cells with disturbed balance of Rac1 effectors, and cells deficient in functional Rac1. Dynamics of the probes for Rac1, its effectors, and F-actin will be studied experimentally in live cells and theoretically. This interdisciplinary project is designed to optimize the use of resources and bring together researchers with the expertise in a range of disciplines, including molecular and cellular biology, biochemistry, microscopy, and theoretical biophysics. Through joining forces of all investigators of the cytoskeletal dynamics in Croatia, we intend to assemble a team that will play a prominent role in this field of research internationally.]]></summary_en></project><project>
<id>3311</id><title_hr><![CDATA[Napredna 3D percepcija za mobilne robotske manipulatore]]></title_hr><title_en><![CDATA[Advanced 3D Perception for Mobile Robot Manipulators]]></title_en><user_id>6310</user_id><user_firstLast_name>Robert Cupec</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-3155</code><acronim><![CDATA[ARP3D]]></acronim><duration>01.01.2016 - 31.12.2019</duration><status>Završio</status><financ_value>125.918,24 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, Računarstvo, </scie_field_hr><scie_field_en>Electrical engineering, Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera Osijek, Fakultet elektrotehnike, računarstva i informacijskih tehnologija Osijek]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Electrical Engineering, Computer Science and Information Technology Osijek]]></institution_en><team_members_id>7327, 5672, 6349, 2970, 7388, 7566, 7308, 7332, 18997, 21326, 22820, </team_members_id><team_members_names><![CDATA[Ivan Vidović, Damir Filko, Ratko Grbić, Emmanuel Karlo  Nyarko, Tomislav Keser, Ivan Aleksi, Ivica Lukić, Tomislav Matić, Marina Peko, Petra Đurović, Marko Filipović, ]]></team_members_names><keywords_hr><![CDATA[računalni vid, robotska manipulacija, prepoznavanje objekata, lokalizacija robota, segmentacija, 3D senzori]]></keywords_hr><keywords_en><![CDATA[computer vision, robot manipulation, object recognition, robot localization, segmentation, 3D sensors]]></keywords_en><summary_hr><![CDATA[Unatoč naglom napretku 3D računalnog vida, još uvijek postoji potreba za učinkovitijim, pouzdanijim i fleksibilnijim sustavima robotske percepcije. Osnovni cilj ovog projekta je razviti nove odnosno unaprijediti postojeće metode 3D robotskog vida za primjenu u zadacima robotske manipulacije. Predloženo istraživanje obuhvaća primjenu 3D senzora za izvođenje prototipnih zadataka koji uključuju manipulaciju objektima u kombinaciji sa samostalnim kretanjem u nestrukturiranoj okolini. Težište istraživanja je na robotskoj percepciji zasnovanoj na 3D oblacima točaka dobivenim 3D senzorima, dok su planiranje kretanja i hvatanja objekata uključeni samo radi evaluacije razvijenih rješenja s područja računalnog vida. Istraživanje će se provoditi u tri smjera: (i) segmentacija oblaka točaka i 3D modeliranje; (ii) prepoznavanje objekata; (iii) lokalizacija mobilnog robota. Radi olakšavanja komunikacije između čovjeka i robota, bit će razvijena metoda segmentacije oblaka točaka, koja će rezultirati modelom okoline u obliku zasebnih objekata relevantnih za mobilnu manipulaciju, što će omogućiti korisniku zadavanje zadataka robotu na jednostavan i intuitivan način. Razvijat će se više novih metoda s primjenom u okviru uobičajene strategije raspoznavanja objekata zasnovanog na značakama s ciljem povećanja računske učinkovitosti uz istovremeno postizanje visoke preciznosti i osjetljivosti (engl. precision and recall). Radit će se na osmišljavanju novih značajki za učinkovito generiranje hipoteza. Također će se razvijati nova metoda procjenjivanja vjerojatnosti generiranih hipoteza. Uz ovaj pristup, istraživat će se i primjena slučajnog evolucijskog algoritma pretraživanja te metode podudaranja grafova u prepoznavanju objekata. Razvijeni sustav prepoznavanja objekata bit će nadograđen i prilagođen za prepoznavanje mjesta u okviru sustava za lokalizaciju mobilnog robota. Sve metode razvijene u okviru projekta ispitat će se pokusima s mobilnim robotskim manipulatorom.]]></summary_hr><summary_en><![CDATA[Despite rapid advancement in 3D computer vision, there is still a need for more efficient, reliable and flexible robot perception systems. The main goal of this project is to develop new or improve existing 3D robot vision methods for application in mobile robot manipulation tasks. The proposed research considers application of 3D sensors in execution of prototypical tasks which include object manipulation combined with autonomous motion in an unstructured environment. The focus of the research is on robot perception based on 3D point clouds obtained by 3D sensors, while motion planning and grasping are involved only for the purpose of evaluation of the developed vision-based solutions. The research will be conducted in three directions: (i) point cloud segmentation and 3D modelling; (ii) object recognition; (iii) mobile robot localization. In order to facilitate human-robot communication, a point cloud segmentation method will be developed which will create environment models in the form of separate geometric objects relevant for mobile robot manipulation, providing a user with a simple and intuitive means of defining robot manipulation tasks. Several novel approaches within the framework of a common feature-based object recognition pipeline will be developed with the purpose of increasing the computational efficiency while achieving a high precision-recall characteristic. Novel features for efficient hypothesis generation will be designed. A novel hypothesis probability estimation approach will be developed. Furthermore, application of a random evolutionary search algorithm and graph matching in object recognition will be investigated. The developed object recognition system will be extended and adapted for place recognition within a mobile robot localization framework. All developed approaches will be evaluated by experiments with a mobile robot manipulation.]]></summary_en></project><project>
<id>3317</id><title_hr><![CDATA[Molekularni posrednici koštane resorpcije uvjetovane receptorom Fas u artritisu ]]></title_hr><title_en><![CDATA[Molecular mediators of Fas-driven osteoresorption in arthritis]]></title_en><user_id>3882</user_id><user_firstLast_name>Nataša Kovačić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-7406</code><acronim><![CDATA[MEFRA]]></acronim><duration>01.11.2015 - 31.10.2019</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, Clinical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>3075, 2631, 3895, 4356, 4791, 4786, 13283, 3832, 13336, 13320, 4651, 20922, 22476, 22466, </team_members_id><team_members_names><![CDATA[Danka Grčević, Tomislav Kelava, Alan Šućur, Frane Paić, Branimir Anić, Mislav Cerovec, Katerina Zrinski Petrovic, Elvira Lazić Mosler, Peter Ian Croucher, Nives Zimmermann, Mislav Jelić, Katarina Barbarić, Martina Fadljević, Igor Radanović, ]]></team_members_names><keywords_hr><![CDATA[artritis, Fas, osteoresorpcija, stanična loza, diferencijacija, apoptoza, upala]]></keywords_hr><keywords_en><![CDATA[arthritis, Fas, osteoresorption, lineage, differentiation, apoptosis, inflammation]]></keywords_en><summary_hr><![CDATA[Upalni artritisi su kronične zglobne bolesti, i važan zdravstveni problem zbog progresivne invalidnosti. Najčešći je reumatoidni arthritis (RA) praćen oštećenjem kosti i hrskavice, koji dovode do trajnih deformacija zgloba. Artritis se također često javlja tijekom sistemskog lupusa eritematosusa (SLE), uglavnom kao neerozivni artritis.Tijekom RA, upalne i imunološke stanice stvaraju mikrookoliš koji izaziva resorpciju kosti, potičući sazrijevanje i aktivnost osteoklasta, a kočeći sazrijevanje i aktivnost osteoblasta. Lijekovima poput bioloških sredstava može se promijeniti tijek bolesti, ali ograničeno je djelovanje na koštanu resorpciju. Sustav Fas/Fas ligand važan je regulatore homeostaze imunološkog sustava, a sve je više dokaza  o njegovoj važnosti u regulaciji koštane homeostaze. Inaktivacija receptora Fas štiti od gubitka kosti izazvanog nedostatkom estrogena, ali i gubitka kosti u upalnom artritisu, međutim stanične loze i signalni putevi koji posreduju taj učinak još nisu u potpunosti poznati. Korištenjem modela artritisa potaknutog antigenom (AIA, prema engl. antigen-induced arthritis) u miševa s izbačenim genom za Fas, te uzoraka sinovijalne tekućine bolesnika s RA i SLE, namjeravamo istražiti fenotip staničnih populacija odgovornih za kočenje osteoresorptivnih zbivanja, te utvrditi funkcijske promjene u tim stanicama globalnom analizom njihovog genskog izražaja. Nadalje, očekujemo da ćemo potvrditi značaj promijenjenih gena/bjelančevina njihovom inaktivacijom in vivo u mišjem modelu AIA, a važnost pojedine loze utvrdit ćemo uporabom miševa sa izbačenim genom za Fas u toj lozi. Analiza ljudskih uzoraka omogućit će razumijevanje značenja navedenih promjena u kliničkoj primjeni.   Naš pristup ima za cilj otkriti nove molekularne posrednike koštane resorpcije u upalnim artritisima, na razini specifičnoj za staničnu lozu. Predloženo istraživanje otvorit će nove mogućnosti za sprječavanje, ublažavanje i liječenje koštane resorpcije u upalnim zbivanjima.]]></summary_hr><summary_en><![CDATA[The inflammatory arthritides are chronic joint diseases, and a major health problem because of progressive disability. The most common form is rheumatoid arthritis (RA) characterized by bone and cartilage damage leading to deformity and permanent disability. Arthritis is also a common in systemic lupus erythematosus (SLE), mostly as a non-erosive form.In RA, inflammatory and immune cells create a microenvironment that favors osteoresorption by increasing osteoclast, and suppressing osteoblast differentiation and activity. Current treatment options such as biological therapeutics may modify the course of disease, but are not able to reverse osteoresorption.The Fas/Fas ligand system is important regulator of immune system homeostasis, and there is accumulating evidence for the role of this system in the regulation of bone homeostasis. Inactivation of Fas has a bone-sparing effect, preventing bone loss upon estrogen withdrawal, as well as in inflammatory arthritides, but the exact lineages and signaling pathways mediating this effect are not defined. Using the murine model of antigen-induced arthritis (AIA) in mice deficient for Fas, and synovial fluid samples from patients with RA and SLE, we aim to identify cell populations responsible for inhibition of osteoresorption, as well as functional alterations in these populations by analysing their gene expression profiles. In addition, we expect to confirm the role of identified genes/molecules by their inactivation in vivo in the murine model of AIA, and the role of a lineage using conditional lineage-specific models of Fas-inactivation. The analysis of human samples will allow for the translation to the clinical setting. Our approach aims to identify novel cellular/molecular drivers of bone resorption in arthritis, on a lineage-specific level. Proposed studies will provide new targets for preventing, reducing, and potentially reversing the osteoresorptive process which is a consequence of inflammatory events.]]></summary_en></project><project>
<id>3323</id><title_hr><![CDATA[Oplemenjivanje pšenice na otpornost prema Fuzarijskoj paleži klasa upotpunjeno s analizama mikotoksina i antioksidativnim putevima]]></title_hr><title_en><![CDATA[Wheat breeding for resistance to Fusarium head blight combined with mycotoxin analysis and antioxidant pathways]]></title_en><user_id>273</user_id><user_firstLast_name>Valentina Španić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2014-09</proposal_call><code>UIP-2014-09-9188</code><acronim><![CDATA[Fuzarij/Fusarium]]></acronim><duration>01.06.2015 - 31.05.2018</duration><status>Završio</status><financ_value>49.996,68 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Poljoprivredni institut Osijek]]></institution_hr><institution_en><![CDATA[Agricultural Institute Osijek]]></institution_en><team_members_id>432, 571, 825, 2820, 408, 51, 334, </team_members_id><team_members_names><![CDATA[Tihana Marček, Ivan Abičić, Daniela Horvat, Marijana Tucak, Kristina Habschied, Marija Viljevac Vuletić, Bojan Šarkanj, ]]></team_members_names><keywords_hr><![CDATA[pšenica, fuzarij, prinos, kvaliteta, mikotoksini, antioksidativna aktivnost]]></keywords_hr><keywords_en><![CDATA[wheat, fusarium, yield, quality, mycotoxins, antioxidative activity]]></keywords_en><summary_hr><![CDATA[Fuzarijska palež klasa (FHB), je problem vrlo raširen u svijetu, ima veliki ekonomski utjecaj na industriju žitarica jer smanjuje kvalitetu sjemena i prinosa pšenice, ali predstavlja čak i ozbiljniji problem u ljudskoj i životinjskoj ishrani jer ova gljiva proizvodi toksične sekundarne metabolite-mikotoksine. Najbolji pristup za kontrolu FHB i smanjivanje onečišćenja mikotoksinima je stvaranje genotipova pšenice koji nose gene otpornosti na FHB. Svrha ovog projekta je pronaći genotipove pšenice koji imaju određenu razinu otpornosti na FHB infekciju, a time i manje količine mikotoksina u prerađenim i neprerađenim proizvodima. Tretman makrokonidijama će se provesti na 50 genotipova ozime pšenice u vrijeme cvatnje u prvoj godini istraživanja. Učestalost i intenzitet bolesti mjerit će se u nekoliko navrata, te će se izračunati površina unutar krivulje bolesti (AUDPC). Za daljnja istraživanja odabrat će se 25 genotipova pšenice na temelju niže učestalosti i inteziteta bolesti i umjetno će se zaraziti u drugoj i trećoj godini istraživanja. U svakoj godini, nakon žetve odredit će se urod zrna, hektolitarska masa, masa 1000 zrna, sadržaj bjelančevina, sadržaj glutena, sedimentacijska vrijednost i reološki parametri pšeničnog brašna. Zato Ovim projektom će se analizirati DON, T-2 i HT-2 toksin, nivalenol, diacetoksiscirpenol, fuzarenon X i zearalenon u zrnu pšenice i pšeničnom sladu. Za dobivanje pouzdanih informacija o utjecaju umjetne infekcije na kvalitetu pšenice, potrebno je proučiti (osim kemijskih i reoloških parametara kvalitete) sastav i količinu proteina pšenice, s naglaskom na glijadine (?-, ?- ?- ) i glutenine (HMW-GS i LMW-GS). Otpornost biljaka na biotički stres izazvan patogenom provjerit će se mjerenjem aktivnosti enzima antioksidativnog sustava (gvajakol peroksidaze, askorbat peroksidaze, superoksid dismutaze, katalaze) Odredit će se i slobodni prolin i malonaldehid. ]]></summary_hr><summary_en><![CDATA[Fusarium head blight (FHB), as a global problem, has a great economic impact on the cereal industry due to reduced seed quality and yield of wheat genotypes, but even most serious problem for human and animal consumption is the capability of the fungus to produce toxic secondary metabolites-mycotoxins. The best approach to control FHB and to reduce mycotoxin contamination is to create wheat genotypes which are carrying effective resistance genes. The purpose of this project is to find the wheat genotypes that have a certain level of resistance to FHB infections. Macroconidia treatment will be carried out at 50 winter wheat genotypes at the time of flowering in the first year of investigation. Disease incidence and intensity will be measured in a couple of occasions to calculate area under disease curve. For further research 25 wheat genotypes will be selected based on the lower disease incidence and intensity and artificially inoculated in the second and third year of investigation. In each year, after harvest we will determine grain yield, test weight, 1000 kernel weight, protein content, gluten content, sedimentation value and rheological parameters of wheat flour. DON, T-2 and HT-2 toxin, nivalenol, diacetoksiscirpenol, fuzarenon X and zearalenone will be analysed in wheat grain and wheat malt. To obtain reliable information on the impact of artificial inoculation on quality of wheat genotype, it is necessary to study (except chemical and rheological parameters of quality) the composition and quantity of wheat proteins, with emphasis on gliadins (?-, ?- ?-) and glutenins (HMW-GS and LMW-GS). Several antioxidant enzymes (guaiacol peroxidase, ascorbate peroxidase, superoxide dismutase, catalase) will be screened in a few occasions in order to find their potential correlation with plant resistance mechanisms to the pathogen attack.  We will also check accumulation of free proline and malondialdehyde content.]]></summary_en></project><project>
<id>3325</id><title_hr><![CDATA[Multimodalni pristup liječenju i dugoročnom praćenju tijeka depresivnog poremećaja metodom magnetske rezonancije]]></title_hr><title_en><![CDATA[Multimodal approach to treatment and long-term assessment of depressive disorder using magnetic resonance imaging]]></title_en><user_id>5929</user_id><user_firstLast_name>Neven Henigsberg</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-2979</code><acronim><![CDATA[MODERN]]></acronim><duration>01.07.2015 - 30.09.2018</duration><status>Završio</status><financ_value>89.738,40 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Kliničke medicinske znanosti, Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Clinical sciences, Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>7379, 7226, 6534, 7272, 6466, 13608, 3662, 5845, 13578, 13598, 13480, 13311, 13496, 13563, 13637, 7381, 6937, 7225, 7090, 13638, 7088, 13652, 7333, </team_members_id><team_members_names><![CDATA[Vlado Jukić, Dragica Kozarić-Kovačić, Marko Radoš, Darko Marčinko, Antoinette Kaić-Rak, Miroslav Herceg, Dragan  Nimac, Viktorija Erdeljić Turk, Dubravka Kalinić, Dario Bagarić, Snježana Spitzmüller Šurlan, Aleksandar Savić, igor filipcic, Maja  Bajs Janović, Špiro Janović, Petrana Brečić, Helena Šarac, Zrnka Kovačić Petrović, Petra Kalember, Benedict Rak, Pero Hrabač, Tomislav Madžar, Mladen Loncar, ]]></team_members_names><keywords_hr><![CDATA[depresivni poremećaj, spektroskopija magnetskom rezonancijom, liječenje, prognoza, relaps]]></keywords_hr><keywords_en><![CDATA[depressive disoreder, magnetic resonance spectroscopy, treatment, prognosis, relapse]]></keywords_en><summary_hr><![CDATA[Cilj projektnog prijedloga je uspostaviti jedinstveni i novi pristup liječenju i dugoročnoj procjeni učinaka depresije. Koristit ćemo mrežu vodećih istraživača u područjima magnetske rezonancije, spektroskopije, tradicionalnih psihijatrijskih pristupa pacijentu i etike. Očekujemo da će rezultati projekta predstavljati značajan doprinos personaliziranom pristupu u liječenju depresije, objektivnom prikazivanju rezultata liječenja i procijeni učinaka bolesti na stanje oboljelog kao i na trošak koji predstavlja za zajednicu.]]></summary_hr><summary_en><![CDATA[The aim of the proposal is to establish a unique and novel approach to therapy and assessment of long-term effects of depression.We plan to use a network of leading researchers in the fields of magnetic resonance imaging, spectroscopy, traditional psychiatric approach and ethics.As a result, we expect to bring a major contribution to personalized approach in treatment of depression, objectivising of treatment results and assessment of effects of the disease and the treatment on the wellbeing of the individual and its cost to the society.]]></summary_en></project><project>
<id>3326</id><title_hr><![CDATA[Mjeriteljska infrastruktura za pametne mreže]]></title_hr><title_en><![CDATA[Smart Grid metrology infrastructure]]></title_en><user_id>5372</user_id><user_firstLast_name>Roman Malarić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-8826</code><acronim><![CDATA[SMAGRIMET]]></acronim><duration>25.08.2015 - 24.08.2019</duration><status>Završio</status><financ_value>127.878,43 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, Temeljne tehničke znanosti, </scie_field_hr><scie_field_en>Electrical engineering, Basic engineering sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>4309, 3516, 5507, 142, 1484, 5389, 3230, 12749, 1370, 4942, 7406, 5483, 11130, 21319, 21317, 5165, 25330, </team_members_id><team_members_names><![CDATA[Marin Despalatović, Tonko Garma, Hrvoje Hegeduš, Marko Jurcevic, Tomislav Kilić, Petar Mostarac, Goran Petrović, Goran Majić, Dubravko Sabolić, Igor Štambuk, Ivica Kunšt, Kruno Miličević, Zeljko Martinovic , Juraj Alojzije Bosnić, Jure Konjevod, Branimir Ivšić, Antonijo Kunac, ]]></team_members_names><keywords_hr><![CDATA[Pametne mreže, mjeriteljstvo, precizne mjerne metode, mjerenje snage, mjerenje energije]]></keywords_hr><keywords_en><![CDATA[Smart grid, metrology, precise measurement methods, measurement of power, measurement of energy]]></keywords_en><summary_hr><![CDATA[Cilj ovog projekta je izgradnja nacionalne mjeriteljske infrastrukture za podršku Smart Grid tehnologiji, koja u potpunosti nedostaje u trenutnoj hrvatskoj mjeriteljskoj infrastrukturi. Nedostaje čak i nacionalni etalon za snagu i energiju. SMAGRIMET će biti glavni centar za istraživanje i razvoj potrebne mjeriteljske infrastrukture u Republici Hrvatskoj za smart grid i srodna znanstvena područja koji će učinkovito premostiti jaz između hrvatske i europske mjeriteljske infrastrukture. Većina europskih mjeriteljskih instituta sudjelovala je u projektu razvoja Smart Grid mjeriteljske infrastrukture u kojem Hrvatska nije sudjelovala zbog nedostatka infrastrukture za mjerenje snage i energije i povezanih istraživanja vezana za pametne mreže. Istraživanje u ovom projektu će biti usmjereno na razvoj vrlo preciznih naponskih i strujnih mjernih pretvornika, pomoću analogno digitalnih pretvornika i koristeći nove algoritme za preciznu analizu mjernih podataka. Ovaj istraživački projekt će adresirati niz mjeriteljskih izazova koji će pružiti neophodnu podršku kako bi se osigurala sigurnost opskrbe električnom energijom i stabilnost mreže. Izazovi su mnogi: Mjerni okvir za nadzor i stabilnost pametne mreže, sljedivost mjerenja na udaljenim lokacijama energetske infrastrukture koji osiguravaju pravednu trgovinu energijom, daljinsko mjerenje u energetskim postrojenjima i kućanstvima, kvalitetu i učinkovitost energije te modeliranje, simulacija i analiza stanja pametne mreže. Također, uvođenje novog standarda IEC 61850 će promijeniti način na koji će trafostanica funkcionirati u budućnosti, a novi izazovi i rješenja tek trebaju biti istraženi i razvijeni. ]]></summary_hr><summary_en><![CDATA[The aim of this project is to build national metrology infrastructure to support smart grid technology and research, as it is completely lacking in the current Croatian metrology infrastructure. Even, the power and energy national standard is missing.The SMAGRIMET will be main centre for research and development of necessary metrological infrastructure in Croatia for smart grid and related scientific fields that will effectively bridge the gap between the Croatian metrological infrastructure and European counterparts. Most of the European metrological institutes have contributed to the European Smart grid metrology project in which Croatia has not taken part because of the lack of infrastructure for measuring power and energy and related issues related to smart grids.The research will be focused in developing highly accurate voltage and current transducers, using precision sampling devices and using new algorithms to accurately analyse measurement data.This research project addresses a series of metrological challenges that will provide essential support to ensure security of electricity supply and grid stability, grid quality, and fair trade between commercial parties employing the grid. The challenges are many: Measurement framework for monitoring stability of smart grids, traceable on-site energy measurement systems for ensuring fair energy trade, remote on-site measurement of power quality and efficiency and modelling, simulation and network analysis of the system state of smart grids-. Also the introduction of the new standard IEC 61850 will change the way the substation will function in the future. The standard makes new challenges and solutions have yet to be researched and developed.]]></summary_en></project><project>
<id>3331</id><title_hr><![CDATA[Reprogramiranje citoprotektivnih puteva u mezoteliomu]]></title_hr><title_en><![CDATA[Reprogramming cytoprotective pathways in malignant mesothelioma]]></title_en><user_id>5915</user_id><user_firstLast_name>Sven Seiwerth</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-4173</code><acronim><![CDATA[ReprogrammingMM]]></acronim><duration>01.12.2015 - 30.11.2019</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Kliničke medicinske znanosti, Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Clinical sciences, Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>4853, 6755, 4991, 5270, 5078, 3422, 4867, 6223, 25311, </team_members_id><team_members_names><![CDATA[Luka Brčić, Ana Šepac, Iva Brčić, Kristina Meljanac Salopek, Hoda Mir Alireza, Marko Jakopovic, Marija Mišić, Balazs Dome, Sunčana Sikirić, ]]></team_members_names><keywords_hr><![CDATA[matične stanice, pluripotencija, reprogramiranje, mezoteliom, citoprotekcija, onkogeni]]></keywords_hr><keywords_en><![CDATA[stem cells, pluripotency, reprogramming, malignant mesothelioma, cytoprotection, oncogenes]]></keywords_en><summary_hr><![CDATA[Vjeruje se da je evolucija malignih tumora stohastički proces potaknut mutacijama koje uzrokuju aktivaciju i inaktivaciju glavnih gena kojima tumorske stanice stječu fenotipske prednosti pred normalnim stanicama što im omogućava proliferaciju, lokalnu migraciju i metastaziranje. Svježi podaci ukazuju da su neke od osnovnih značajki malignosti jednake normalnim pocesima u embrionalnom razvoju koji je programiran i precizno reguliran. Subpopulacija tumorskih stanica koja pokazuje svojstva pluripotentnih stanica, tzv. tumorske matične stanice, imaju bitnu ulogu u rezistenciji na radio- i kemoterapiju, mirovanje tumora te metastaziranje. Mi ćemo proučavati maligne karakteristike mezotelioma koje su potaknute programiranim procesima povezanim s regulacijom pluripotentnosti i koje mogu biti modificirane vanjskim djelovanjem. Opća hipoteza je da je rezistencija na oksidativni stres i kemoterapiju u stanicama mezotelioma regulirana onkogenim putem PI3K/AKT/BCL2. Istražit će se može li se ovaj put kontrolirati glavnim regulatorima pluripotencije i diferencijacije uz pomoć reprogramiranja. Stanice mezotelioma će se reprogramirati u pluripotentno stanje uvođenjem specifičnih čimbenika tvoreći inducirane pluripotentne mezoteliomske matične stanice. Dobivene stanice će se diferencirati u tri linije. Ovo će nam omogućiti da odredimo može li ovakva eksperimentalna perturbacija smanjti aktivnost onkogenog puta PI3K/AKT/BCL2 koji bi mogao kontrolirati mitohondrijske citoprotektivne puteve. Konačno takva intervencija može stanice učiniti osjetljivijima na oksidativni stres i kemoterapeutike. In vitro studije će biti poduprijete s klinički relevantnim histopatološkim ispitivanjem tumora pacijenata u kojem ćemo usporediti diferencijacijski status, aktivnost PI3K/AKT/BCL2 puta i preživljenje pacijenata. ]]></summary_hr><summary_en><![CDATA[It is generally believed that the evolution of a cancer is a stochastic process of mutation-induced activation and inactivation of principal genes by which tumor cells acquire phenotypic advantages over normal cells allowing them to proliferate and migrate locally and to remote organs. Recent data indicate that some of key features of malignancy are similar to normal processes of embryonic development, which are programmed and highly regulated. The subpopulation of cancer cells that exhibit properties of embryonic stem cells are called cancer stem cells (CSCs) and studies showed their essential role in resistance to radio- and chemotherapy, tumor dormancy and metastasizing. We aim to investigate malignant characteristics of mesothelioma that are driven by programmed processes associated with the regulation of pluripotency, and which can be modified by exogenous treatment. Our overall hypothesis is that the resistance to oxidative stress and chemotherapeutics in mesothelioma cells is regulated by the activity of oncogenic pathway PI3K/AKT/BCL2. It will be investigated whether this pathway can be controlled with master regulators of pluripotency and differentiation by reprogramming mesothelioma cells. Mesothelioma cells will be reprogrammed to pluripotent state with introduction of defined factors yielding induced pluripotent mesothelioma stem cells (iPMSCs). iPMSCs will be differentiated into three different lineages. This will allow us to determine whether such experimental perturbation decreases activity of the specific oncogenic pathway PI3K/AKT/BCL2 that may control mitochondrial cytoprotective pathways. Ultimately such intervention may render cells more sensitive to oxidative stress and chemotherapeutics. In vitro studies will be corroborated with clinically relevant histopathological examination of patient’s tumors where correlation among differentiation status, PI3K/AKT/BCL2 pathway activity and patient’s survival will be examined. ]]></summary_en></project><project>
<id>3333</id><title_hr><![CDATA[Novi, učinkoviti iteracijski postupak proračuna konstrukcija - poopćenje suvremenih postupaka]]></title_hr><title_en><![CDATA[ Novel, Efficient Iterative Procedure for the Structural Analysis - Generalisation of Modern Methods]]></title_en><user_id>13097</user_id><user_firstLast_name>Damir Lazarević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-2899</code><acronim><![CDATA[YODA]]></acronim><duration>01.09.2015 - 31.08.2019</duration><status>Završio</status><financ_value>78.518,68 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Temeljne tehničke znanosti, Građevinarstvo, </scie_field_hr><scie_field_en>Basic engineering sciences, Civil engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Građevinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Civil Engineering]]></institution_en><team_members_id>13251, 13695, 13254, 12842, 13267, 21063, </team_members_id><team_members_names><![CDATA[Josip Dvornik, Krešimir Fresl, Antonia Jaguljnjak Lazarević, Mario Uroš, Petra Gidak, Elizabeta Šamec, ]]></team_members_names><keywords_hr><![CDATA[brza iteracijska metoda, Ritzova metoda, štedni zapis matrice, ocjena točnosti, poopćenje iteracijskih postupaka]]></keywords_hr><keywords_en><![CDATA[fast iterative method, Ritz method, sparse matrix storage, accuracy estimate, generalization of iterative methods]]></keywords_en><summary_hr><![CDATA[Zamisao je projekta razviti brzi iteracijski postupak proračuna konstrukcija koji je za jednaki utrošak memorije brži, a za nešto veći utrošak memorije izrazito brži od suvremenih izravnih i iteracijskih postupaka proračuna. Postupak koji predlažemo ima i dodatnu važnost jer se većina suvremenih iteracijskih postupaka može prikazati kao poseban slučaj našeg postupka pa ga možemo smatrati poopćenjem većine suvremenih iteracijskih postupaka. Ukratko, radi se zapravo o iteracijskom postupku kod kojega se u svakom koraku iteracije primjenjuje diskretna Ritzova metoda. U svakom se koraku generiraju koordinatni vektori koji tvore podprostor unutar kojega se traži lokalni minimum energije čime se ukupna energija smanjuje i konvergira traženom minimumu. Broj koordinatnih vektora (dimenzija podprostora) nije ograničen, ali teži se tomu da bude što manji – puno manji od broja nepoznanica. Generiranje kvalitetnog podprostora - koordinatnih vektora središnji je problem kojiunutar projekta treba riješiti. Uglavnom, metodom koju predlažemo moguće je kombinirati dobra svojstva nekoliko iteracijskih postupaka istodobno. Štoviše, svaki novi postupak generiranja vektora otvara mogućnost ubrzanja našeg postupka. Nadalje, svojstvo konjugiranosti na kojemu se temelje neki iteracijski postupci i koje vrijedi samo u linearnim problemima, u našem slučaju nije nužno potrebno pa se metoda može uspješno primijeniti i u nelinearnim proračunima kod kojih svojstvo konjugiranosti uopće nije definirano. Tada se za praktične primjere isključivo koriste iteracijski postupci proračuna. Konačno, primjenom naših, izvornih, metoda cjelobrojne aritmetike, možemo odrediti točno rješenje prikladnih, praksi realnijih (ne samo trivijalnih, tzv. benchmark) primjera pa možemo ocijeniti konvergenciju, stabilnost i točnost bilo kojeg numeričkog pa i našeg postupka.]]></summary_hr><summary_en><![CDATA[The idea of the project is to develop a fast iterative method for structural analysis which is, in the case of equal memory usage, faster and for larger memory usage, much faster than modern direct and iterative solvers. The procedure that we propose has additional importance, because the majority of modern iterative methods can be represented as a special case of our procedure. Therefore, it can be considered as a generalization of most modern iterative methods. In brief, it is actually an iterative procedure in which at each iteration step, discrete Ritz method is applied. At every step, coordinate vectors which form a subspace are generated, within which local energy minimum is sought, thus decreasing the total energy of the system, which therefore converges to the required minimum. The number of coordinate vectors (subspace dimension) is not limited, but aims to be small - much smaller than the number of unknowns. How to generate a good subspace - coordinate vectors is the central problem the project needs to address. Basically, with the method proposed it is possible to combine the good properties of several iterative methods simultaneously. Furthermore, every new vector generation procedure opens the possibility to fasten our method. Additionally, the property of conjugacy which underlies some iterative procedures and which is valid only in linear problems, in our case is not absolutely necessary. Therefore, the method can be successfully applied in nonlinear calculations in which the conjugacy is not even defined. This fact is really important, because in the case of nonlinear practical applications, iterative methods are used exclusively. Finally, applying our original method based on integer arithmetic, the exact solution of appropriate, practical, realistic (not just simple, benchmark) examples can be determined, so we can evaluate the convergence, stability and accuracy of any numerical procedure, including the method proposed.]]></summary_en></project><project>
<id>3337</id><title_hr><![CDATA[Novi metal-organski sustavi s oksalatnim i kinoidnim ligandima s podešenim svojstvima pogodnim za primjenu]]></title_hr><title_en><![CDATA[Novel metal-organic systems based on the oxalate and quinoid ligands with tuned properties suitable for applications]]></title_en><user_id>13343</user_id><user_firstLast_name>Krešimir Molčanov</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-4079</code><acronim><![CDATA[NMOSBOQLWTPSFP]]></acronim><duration>01.05.2015 - 30.04.2019</duration><status>Završio</status><financ_value>121.136,11 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, Fizika, </scie_field_hr><scie_field_en>Chemistry, Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>12831, 11146, 13002, 12971, 21308, 21309, </team_members_id><team_members_names><![CDATA[Marijana Jurić, Jasminka Popovic, Martina Vrankić, Lidija Androš, Lidija Kanižaj, Valentina Milašinović, ]]></team_members_names><keywords_hr><![CDATA[funkcionalni materijali, kristalno inženjerstvo, kristalna struktura, magnetska svojstva, koordinacijski polimeri, miješani oksidi, oksalati, kinoni]]></keywords_hr><keywords_en><![CDATA[functional materials, crystal engineering, crystal structure, magnetic properties, coordination polymers, mixed metal oxides, oxalates, quinones]]></keywords_en><summary_hr><![CDATA[Cilj projekta je učinkovit i postupan dizajn novih i naprednih funkcionalnih materijala temeljenih na metal-organskim kompleksima. Kombinacijom metalnih centara s polidentatnim organskim ligandima dobivaju se strukturno raznolike rešetke različitih magnetskih električnih, termičkih, optičkih i drugih svojstava. U predloženom projektu, dva analogna premošćujuća liganda, oksalat i supstituirani 2,5-dihidroksikinonat (DHQ), koristit će se u pripravi koordinacijskih polimera različite dimenzionalnosti i topologije. Njihove interakcije s prijelaznim metalnim kationima obuhvaćaju različita magnetska svojstva, koje se mogu mijenjati izborom točno određenih strukturnih fragmenata. Oksalatni kompleksi će se istraživati ne samo kao mogući magnetski materijali s uređenjem pri određenoj temperaturi, nego kao i prekursori za pripravu tehnološki važnih miješanih metalnih oksida termičkom razgradnjom u jednom koraku. Ova metoda priprave oksida, u odnosu na standardne reakcije u čvrstom stanju, ima nekoliko prednosti: kraća termička obrada na nižoj temperaturi, nema ponavljanja postupaka mljevenja, a produkti su homogeniji. DHQ-kompleksi proučavat će se zbog njihovog potencijala za prijenos naboja, što bi moglo dovesti do materijala s reverzibilnim magnetskim prijelazom. Također, obećavajuća skupina liganada su stabilni semikinonski radikali, dobiveni iz različito supstituiranih DHQ-ova. Njihovi su kompleksi s prijelaznim metalima do sada malo poznati i nisu bili korišteni za izradu funkcionalnih materijala. Interdisciplinarnost projekta zahtjeva različite metode za karakterizaciju ovih naprednih materijala: difrakciju rendgenskih zraka na monokristalu i prahu, uključujući određivanje gustoće naboja, termičku analizu (TG / DTA), IR-, UV/Vis- i EPR-spektroskopiju, itd. Dobiveni će se rezultati koristiti za povezivanje njihovih struktura i svojstava.]]></summary_hr><summary_en><![CDATA[The project targets at efficient and progressive design of novel and advanced functional materials based on metal-organic complexes. Combination of metal centres with polydentate organic ligands provide colossal, structurally-diverse, platforms possessing a variety of magnetic, electrical, thermal, optical and other properties. In the proposed project, two analogue bridging ligands, oxalate and substituted 2,5-dihydroxyquinonate (DHQ), will be used in the preparation of the coordination polymers of different dimensionality and topology. Their interactions with transition metal cations involve a variety of magnetic phenomena, which can be tuned by highly sensitive selection of structural fragments. The oxalate-based complexes will be studied not only as potential magnetic materials ordering at a certain temperature, but also as the single-source precursors for the preparation of technologically important mixed-metal oxides through the thermal decomposition process. This method of preparing oxides, as compared to conventional solid-state reactions, has several advantages: shorter thermal treatment at lower temperature, without repeating grinding procedures, and the products are more homogeneous. The DHQ complexes will be studied due to their potential for charge transfer, which may lead to materials with reversible magnetic transition. Also, promising class of the ligands are stable semiquinone radicals derived from variously substituted DHQs. So far, their complexes with transition metals are little-known and have not been exploited for design of functional materials.The interdisciplinary nature of the project requires a variety of methods to characterise these advanced materials: single-crystal and powder X-ray diffractions including X-ray charge density studies, thermal analyses (TG/DTA), IR, UV/Vis and EPR spectroscopies, etc. The results obtained will be used to correlate their structure and properties.]]></summary_en></project><project>
<id>3338</id><title_hr><![CDATA[Kredni geodinamski dokazi u području Dinarida i Panonskog bazena]]></title_hr><title_en><![CDATA[Cretaceous GEOdynamic PROOFS in the Dinarides and Pannonian Basin]]></title_en><user_id>9942</user_id><user_firstLast_name>Dražen Balen</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-9541</code><acronim><![CDATA[GEOPROOFS]]></acronim><duration>01.06.2015 - 31.05.2019</duration><status>Završio</status><financ_value>117.295,11 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Geologija, </scie_field_hr><scie_field_en>Geology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>1404, 13375, 7702, 12953, 13066, 13340, 13393, 3166, 13363, 13361, 3920, 23142, </team_members_id><team_members_names><![CDATA[Darko Tibljaš, Davor Pavelić, Bruno Tomljenović, Igor Vlahović, Ivo Velić, Blanka Cvetko Tešović, Marijan Kovačić, Borna Lužar-Oberiter, Zorica Petrinec, Frane Marković, Maja Martinuš, Petra Schneider, ]]></team_members_names><keywords_hr><![CDATA[kreda, geodinamika, procesi, Dinaridi, Panonski bazen]]></keywords_hr><keywords_en><![CDATA[Cretaceous, geodynamics, processes, Dinarides, Pannonian Basin]]></keywords_en><summary_hr><![CDATA[Izuzetno složeni geološki sustav koji obuhvaća Dinaride, kristalinsku podlogu Panonskog bazena te njihova okolna područja jedno je od znanstveno najintrigantnijih područja Europe. U periodu krede, posebno na granici gornje i donje krede, značajni odjeci geodinamskih procesa koji su se odvijali na globalnoj razini identificirani su u stijenama kristalinske podloge, kao i u sinorogenetskim klastičnim sedimentima, ali i u sedimentnom zapisu ranije vrlo stabilne karbonatne platforme. Detaljno istraživanje te definiranje kristalinskih stijena različitih krednih starosti, njihovo porijeklo i način pojavljivanja, zajedno s istraživanjem brojnih i raznolikih klastičnih formacija koje pripadaju slijedu taložnih bazena nastalih u različitim tektonskim okolišima, razotkrit će trenutno prikrivene odnose između magmatskih, metamorfnih i sedimentnih procesa i tektonskih zbivanja. Ta su tektonska zbivanja rezultat međuovisne (geo)dinamske evolucije velikih tektonskih jedinica koje su pripadale promatranom području u vrijeme krede. Dobiveni će podaci biti upotpunjeni analizom raznolikosti facijesa koja je ostala zabilježena u gornjokrednom slijedu Krških Dinarida.Predloženi će projekt biti realiziran kroz paralelna terenska, kabinetska i laboratorijska istraživanja, korištenjem suvremenih metoda i postupaka istraživanja koje će provoditi tri dijelom preklapajuće radne skupine u stalnoj interakciji. One će biti usmjerene na istraživanja kristalinske podloge, sedimentološka istraživanja okolnih/obližnjih klastičnih taložnih bazena te na istraživanje varijabilnosti istovremenih okoliša karbonatne platforme. Prikupljeni će podaci značajno doprinijeti rekonstrukciji geodinamske evolucije Dinaridsko-alpsko-panonskog područja kao cjeline. U tom bi kontekstu rezultati prikupljeni ovakvim složenim i  multidisciplinarnim pristupom bili od općeg interesa za sve koji se bave geološkom prošlosti alpinske Europe, kao i današnjeg Dinaridsko-alpsko-panonskog područja.]]></summary_hr><summary_en><![CDATA[The extremely complex geological system encompassing the Dinarides, Pannonian Basin crystalline basement, and their adjoining areas, is among the scientifically most intriguing areas in Europe. In the Cretaceous period, especially at the Early and Late Cretaceous time boundary, significant echoes of large-scale geodynamic process(es) have been identified in the geological record within crystalline basement rocks, as well as in clastic synorogenic sediments, and even on the previously very stable carbonate platform. Meticulous investigation and recognition of the characteristics of crystalline rocks of different Cretaceous ages, origin and occurrence, along with the investigation of numerous distinct clastic formations belonging to successive basins from different tectonic environments will reveal the presently obscured interrelations among igneous, metamorphic, sedimentary processes and tectonic events. These events are the result of interdependent evolutionary dynamics of large tectonic units belonging to the investigated area during Cretaceous. The obtained data will be complemented by analysis of the facies variability recorded within the Upper Cretaceous successions of the Karst Dinarides.The proposed project will be conducted by parallel field work, cabinet and laboratory research and performed through up-to-date methods and investigation procedures of three partly overlapping and continuously interacting working groups devoted to crystalline basement research, sedimentary research of neighboring clastic basins, and the study of variable penecontemporaneous environments of the carbonate platform realm. The collected data will considerably contribute to the reconstruction of the geodynamic evolution of the Dinaridic-Alpine-Pannonian realm as a whole. As such, the results revealed by the complex, multidisciplinary insight would be of general interest for those dealing with the geological history of Alpine Europe and the present Dinaridic-Alpine-Pannonian realm.]]></summary_en></project><project>
<id>3340</id><title_hr><![CDATA[Održivi razvoj inovacije u hrani - valorizacija otpada masline]]></title_hr><title_en><![CDATA[Valorization of olive waste in sustainable food  innovation]]></title_en><user_id>3927</user_id><user_firstLast_name>Dubravka Vitali Čepo</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2014-09</proposal_call><code>UIP-2014-09-9143</code><acronim><![CDATA[NutriOliWa]]></acronim><duration>15.09.2015 - 14.09.2018</duration><status>Završio</status><financ_value>46.917,51 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Prehrambena tehnologija, Biotehnologija, Prehrambena tehnologija, Nutricionizam, </scie_field_hr><scie_field_en>Food technology, Biotechnology, Food technology, Nutrition, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Farmaceutsko-biokemijski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Pharmacy and Biochemistry]]></institution_en><team_members_id>3517, 3915, 4167, 448, 21380, 21381, </team_members_id><team_members_names><![CDATA[Marija Grdić Rajković, Mario Jug, Marijana Zovko Končić, Suzana Rimac Brnčić, Kristina Radić, Sanja Jurmanović, ]]></team_members_names><keywords_hr><![CDATA[otpad masline, održivi razvoj,  dodatak prehrani, antioksidans, bioraspoloživost, polifenoli]]></keywords_hr><keywords_en><![CDATA[olive waste, sustainable development, antioxidant, food supplement, bioavailability, polyphenols]]></keywords_en><summary_hr><![CDATA[Direktno odlaganje u okoliš otpada koji zaostaje nakon proizvodnje maslinovog ulja, veliki je ekološki problem. Ponovno iskorištavanje otpada masline u samom je začetku te njen potencijal, kao polazne sirovine, još uvijek nije ni izbliza iskorišten. Polifenoli u otpadu masline prepoznati su kao visokovrijedni spojevi no usprkos velikom broju bioloških učinaka, njihova primjena u područjima funkcionalne hrane i dodataka prehrani kao i daljnja istraživanja njihove bološke učinkovitosti vrlo su ograničena. Glavnih razlozi tome su nedostatak prihvatljivih metoda izolacije; te loša kvaliteta i karakterizacija postojećih ekstrakta što dodatno ograničava njihovu širu primjenu i istraživanje. Stoga su glavni ciljevi projekta:1. razviti učinkovit i ekološki prihvatljiv postupak ekstrakcije polifenola iz komine masline korištenjem suvremenih, nekonvencionalnih tehnika kao što su primjena ultrazvuka ili mikrovalova, zasebno ili u kombinaciji s procesom mikroenkapsulacije. 2. razviti inovativne i održive protokole formulacije visokokvalitetnog krutog ekstrakta korištenjem inovativnih tehnoloških i metodoloških pristupa 3. provesti funkcionalnu karakterizaciju dobivenih ekstrakata korištenjem suvremenih in vitro metodoloških pristupa (antioksidacijska aktivnost u modelima hrane, bioraspoloživost, apsorpcija i metabolizam polifenola iz čvrstih ekstrakta, biološka učinkovitost) Osim što će pružiti nove znanstvene spoznaje te mogu poslužiti kao izvrstan temelj za daljnja znanstvena istraživanja specifičnih bioloških učinaka, rezultati ovog projekta nalaze i vrlo konkretnu primjenu u okvirima prehrambene- i farmaceutske industrije. U širem smislu, rezultati ovog projekta pružit će bitan doprinos kvaliteti upravljanja otpadom iz agro-prehrambenog sektora što će rezultirati značajnom ekološkom i ekonomskom korišću u budućnosti.  ]]></summary_hr><summary_en><![CDATA[The olive oil industry gives place to vast amounts of residues and when discarded untreated directly to the environment, they present a major ecological issue. Although some of these residues are beginning  to be managed to a certain extent, higher benefits should be obtained from these materials. Polyphenols abundant in olive waste have been recognized as compounds of high added value but due to the lack of efficient methods of isolation; significant variations in quality of available extracts and lack of their chemical characterization, the possibilities of further investigation of their health related properties  and utilization in the segment of functional foods or dietary supplements is very limited. The major goals of this projects are:1. to develop sustainable procedure for the extraction of polyphenols from olive waste by using unconventional extraction techniques such as ultratrasound- and microwave assisted extraction, alone or in combination with microencapsulation. That should provide significant advantages over the traditional extractions methods 2. to develop efficient drying procedure for obtaining crude olive pomace extracts (COPE) using contemporary methodological approaches with satisfactory physico-chemical properties, organoleptic characteristics and increased shelf-life. 3. to provide functional characterization of COPE using contemporary methodological approaches (bioavailability and absorption of active compounds from COPE, antioxidant activity in food model systems and biological activity)In addition to providing novel scientific knowledge and serve as the excellent starting point for further scientific investigations of particular biological activities, the results of this project have great potential to be further used by food- and pharmaceutical industry. Also, in broader sense, obtained results will contribute to the meaningful management of olive mill waste resulting with both economical and ecological benefit in the future.]]></summary_en></project><project>
<id>3345</id><title_hr><![CDATA[Obrazovne aspiracije učenika u prijelaznim razdobljima hrvatskog osnovnoškolskog obrazovanja: priroda, odrednice i promjene]]></title_hr><title_en><![CDATA[Educational Aspirations of Pupils at Transitional Periods of Croatian Elementary Education: Nature, Determinants and Change]]></title_en><user_id>861</user_id><user_firstLast_name>Boris Jokić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2014-09</proposal_call><code>UIP-2014-09-6757</code><acronim><![CDATA[COBRAS]]></acronim><duration>01.02.2016 - 31.01.2019</duration><status>Završio</status><financ_value>36.961,96 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Psihologija, </scie_field_hr><scie_field_en>Psychology, </scie_field_en><institution_hr><![CDATA[Institut za društvena istraživanja]]></institution_hr><institution_en><![CDATA[Institute for Social Research in Zagreb]]></institution_en><team_members_id>862, 7765, 12779, 12645, 12642, 21232, 21221, </team_members_id><team_members_names><![CDATA[Zrinka Ristić Dedić, Iris Marušić, Gordana Kuterovac Jagodić, Jelena Matić, Inja Erceg Jugović, Iva Košutić, Josip Šabić, ]]></team_members_names><keywords_hr><![CDATA[obrazovne aspiracije, učeničke perspektive, prijelazna obrazovna razdoblja, longitudinalno istraživanje, integrirani nacrt miješanog modela]]></keywords_hr><keywords_en><![CDATA[educational aspirations, pupil perspective, transitional periods in education, longitudinal study, fully integrated mixed model design]]></keywords_en><summary_hr><![CDATA[S ciljem istraživanja prirode, odrednica i promjena obrazovnih aspiracija učenika u prijelaznim razdobljima hrvatskog osnovnoškolskog obrazovanja, u projektu se primjenjuje longitudinalni integrirani nacrt miješanog modela u kojem se kombiniraju kvalitativne i kvantitativne metode prikupljanja podataka. Obrazovne aspiracije se definiraju kao ambicije i ciljevi učenika u vezi s neposrednim i budućim obrazovnim ishodima. Unutar postavljenog konceptualnog okvira, obrazovne aspiracije se smještaju u središte ekološkog sustava koji seže od neposredne razine pojedinog učenika, preko razine roditelja do udaljenijih razina razreda (vršnjaka) i škole. Za svaku razinu su određeni psihologijski koncepti kojima se ispituju priroda i odrednice obrazovnih aspiracija. Projekt je usmjeren na istraživanje obrazovnih aspiracija učenika iz tri kohorte u tri prijelazna razdoblja osnovnoškolskog obrazovanja: ulazak u osnovnoškolsko obrazovanje (od 1. do 2. razreda), prijelaz s razredne na predmetnu nastavu (od 4. do 5. razreda) i završavanje osnovnoškolskog obrazovanja, prije prelaska u srednjoškolsko obrazovanje (od 7. do 8. razreda). Kvalitativna faza istraživanja obuhvaća dubinsko istraživanje obrazovnih aspiracija nizom polu-strukturiranih intervjua s trijadama sudionika koje se sastoje od učenika, njegovog roditelja i učitelja. U ovoj istraživačkoj fazi, u svakoj od pet izabranih škola bit će praćene 24 trijade tijekom dvije školske godine. Kvantitativna faza istraživanja, čiji je cilj modeliranje odrednica i promjena učeničkih obrazovnih aspiracija, uključuje ponavljanu primjenu upitnika na učenicima 20 zagrebačkih osnovnih škola. U svakoj školi, svi će učenici 4. i 7. razreda biti pozvani na sudjelovanje u tri točke mjerenja tijekom dvije školske godine. Rezultati iz obje istraživačke faze bit će integrirani istovremenim razmatranjem individualnih perspektiva tijekom vremena i korištenjem postupaka statističkog modeliranja na velikim uzorcima. ]]></summary_hr><summary_en><![CDATA[In order to investigate the nature, determinants and change in pupils’ educational aspirations at transitional periods of Croatian elementary education, the project employs a longitudinal fully integrated mixed model design, using both qualitative and quantitative methods. Educational aspirations are defined as the ambitions and goals pupils hold concerning both immediate and future educational outcomes. Within conceptual framework, educational aspirations are placed at the centre of an ecological system extending from the most proximal levels of the individual pupil, through the level of parents to the more distant levels of class (peers) and school. For each level, psychological concepts are selected in order to investigate the nature and determinants of pupils’ aspirations. The research focuses on the aspirations of pupils from three different cohorts at three transitional periods of elementary education: the introduction to elementary education (1st to 2nd grade), the transition from class to subject teaching (4th to 5th) and the completion of elementary education prior to the transition to secondary education (7th to 8th). The qualitative research phase centres on an in-depth exploration of educational aspirations through a series of semi-structured interviews with participant triads made up of a pupil, his parent and teacher. In this research phase, 24 triads in each of five participating schools will be followed over two academic years. The quantitative phase consists of the repeated administration of a pupil questionnaire in 20 randomly selected schools in Zagreb aimed at examining determinants of and change in pupils’ educational aspirations. In each school, all 4th and 7th grade pupils will be invited to participate at three different time-points over two academic years. The results from both research phases will be integrated through a concurrent examination of individual perspectives over time and the use of statistical modelling from the large samples.]]></summary_en></project><project>
<id>3348</id><title_hr><![CDATA[Modeliranje okolišnih aspekata napredne obrade voda za razgradnju prioritetnih onečišćivala]]></title_hr><title_en><![CDATA[Modeling of Environmental Aspects of Advanced Water Treatment for Degradation of Priority Pollutants]]></title_en><user_id>1298</user_id><user_firstLast_name>Tomislav Bolanča</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-7992</code><acronim><![CDATA[MEAoWT]]></acronim><duration>01.09.2015 - 31.08.2019</duration><status>Završio</status><financ_value>128.104,05 eur</financ_value><scie_area_hr>Tehničke znanosti, Prirodne znanosti, </scie_area_hr><scie_area_en>Technological sciences, Natural sciences, </scie_area_en><scie_field_hr>Kemijsko inženjerstvo, Kemija, Temeljne tehničke znanosti, </scie_field_hr><scie_field_en>Chemical engineering, Chemistry, Basic engineering sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet kemijskog inženjerstva i tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Chemical Engineering and Technology]]></institution_en><team_members_id>1122, 6112, 4661, 4674, 1123, 6729, 20856, 25242, </team_members_id><team_members_names><![CDATA[Ana Lončarić Božić, Marko Rogosic, Šime Ukić, Mirjana Novak, Daria Juretić, Bakhtiyor Rasulev, Matija Cvetnić, Antonija Tomić, ]]></team_members_names><keywords_hr><![CDATA[prioritetna onečišćivala, napredni procesi obrade voda, okolišni aspekti, mehanističko modeliranje, molekulsko modeliranje]]></keywords_hr><keywords_en><![CDATA[priority pollutants, advanced water treatment, environmental aspects, mechanistic modeling, molecular modeling]]></keywords_en><summary_hr><![CDATA[Voda je ključni resurs za čovječanstvo koji stvara i održava ekonomski rast i prosperitet. Europska Okvirna direktiva o vodama postavlja strategiju o onečišćenju voda u EU i uključuje listu prioritetnih tvari koje predstavljaju značajan rizik za vodni okoliš. Konvencionalne tehnologije obrade voda većinom se temelje na fizikalnim i biološkim procesima koji nisu adekvatni za učinkovito uklanjanje prioritetnih tvari. Stoga, razvoj održivih tehnologija obrade voda zahtijeva primjenu naprednih kemijskih procesa. Iako je konverzija onečišćivala glavni kriterij u ocjeni učinkovitosti obrade, okolišni aspekti primijenjene tehnologije odnose se na ukupnu kvalitetu obrađene vode koja se može izraziti putem sumarnih ekoloških pokazatelja kvalitete voda. Glavni cilj projekta MEAoWT je predložiti održivu tehnologiju za obradu voda koje sadrže prioritetna onečišćivala (farmaceutike i pesticide) te pružiti metodologiju za predviđanje okolišnih aspekata primijenjene tehnologije koja će služiti kao alat za procjenu kvalitete voda i kontrolu onečišćenja. U tu svrhu, za razgradnju odabranih prioritetnih onečišćivala u vodi primijenit će se UV/H2O2, UV/S2O82- i ferat (VI) oksidacijski procesi. Eksperimentalni će se podaci koristiti za izradu modela kombinirajući statističke, matematičke, mehanističke i strukturne pristupe, koristeći napredne računalne alate. Strukturne karakteristike onečišćivala u vodi, mehanizmi i kinetika razgradnje kao i radni parametri procesa obrade korelirat će se s kvalitetom obrađene vode izražene preko sumarnih ekoloških pokazatelja. Predložit će se metodologija za predviđanje, procjenu i kontrolu okolišnih aspekata tehnologije za obradu voda.]]></summary_hr><summary_en><![CDATA[Water is a crucial resource for humanity, generating and sustaining economic growth and prosperity. The European Water Framework Directive lays the EU water pollution strategy, and includes a list of priority substances which represent a significant risk to aquatic environment. The conventional water treatment technologies rely mostly on physical and biological processes which seem to be inadequate for effective removal of priority substances. Therefore, development of sustainable water treatment technologies requires the application of advanced chemical processes. Although the conversion of pollutants is main criterion in evaluation of treatment efficiency, the environmental aspects of applied technology are related to the overall quality of treated water which can be expressed in the terms of ecological sum-parameters. The main goal of MEAoWT project is to propose sustainable technology for the treatment of water containing priority pollutants (pharmaceuticals and pesticides) and to provide the methodology for the prediction of environmental aspects of applied technology, as a powerful tool for water quality assessment and pollution control. For that purpose UV/H2O2, UV/S2O82- and ferrate(VI) oxidation processes will be applied for the degradation of selected priority pollutants in water. Experimental data will be used for development of models combining statistical, mathematical, mechanistic and structural approaches using advanced computational tools. Structural characteristics of water pollutants, degradation mechanisms and kinetics as well as operating parameters of treatment processes will be correlated with the quality of treated water in terms of ecological sum-parameters. The methodology for prediction, assessment and control of the environmental aspects of water treatment technology will be proposed.]]></summary_en></project><project>
<id>3350</id><title_hr><![CDATA[Ekonomske teškoće obitelji, psihosocijalni problemi i obrazovni ishodi adolescenata u vrijeme ekonomske krize]]></title_hr><title_en><![CDATA[Family economic hardship, psychosocial problems and educational outcomes of adolescents in the time of economic crisis ]]></title_en><user_id>13038</user_id><user_firstLast_name>Marina Ajduković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-8546</code><acronim><![CDATA[FEHAP]]></acronim><duration>10.09.2015 - 09.01.2020</duration><status>Završio</status><financ_value>67.079,00 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Socijalne djelatnosti, Sociologija, Psihologija, </scie_field_hr><scie_field_en>Social work, Sociology, Psychology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Pravni fakultet u Zagrebu]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Law]]></institution_en><team_members_id>13253, 7769, 13047, 13049, 12879, 12829, 12881, 12853, 12956, 18962, 24348, </team_members_id><team_members_names><![CDATA[Ivan Rimac, Gordana Keresteš, Olja Družić Ljubotina, Marijana Kletečki Radović, Linda Rajhvajn Bulat, Lea Skokandić, Nika Sušac, Jelena Ogresta, Miroslav Rajter, Ines Rezo, Petra Kožljan, ]]></team_members_names><keywords_hr><![CDATA[adolescenti,ekonomske teškoće obitelji,rizik siromaštva,eksternalizirani problemi,internalizirani problemi,rizična ponašanja,napuštanje školovanja]]></keywords_hr><keywords_en><![CDATA[adolescents, family economic hardship, risk of poverty, externalized problems, internalized problems, risk behaviours, dropping out of school]]></keywords_en><summary_hr><![CDATA[Cilj projekta je povećati razumijevanje učinaka ekonomskih teškoća obitelji na psihosocijalne i obrazovne probleme adolescenata u vrijeme nacionalne ekonomske krize. Novi integrativni model utjecaja ekonomskih poteškoća obitelji na razvoj adolescenta (IMEPO) će biti provjeren kroz longitudinalni kvantitativni i kvalitativni nacrt istraživanja. Istraživački problemi su: (1) Procijeniti ukupni i individualni doprinos prediktora u IMEPO na psihosocijalni razvoj adolescenata, gdje su kriteriji internalizirani i eksternalizirani problemi, druga rizična ponašanja (konzumacija alkohola i droga, kockanje i rizične seksualne aktivnosti) i obrazovni ishodi, uključujući napuštanje obrazovanja, (2) Usporediti uspješnost dva modela – osnovnog modela financijskog stresa (FSM) i novog IMEPO – u predviđanju psihosocijalnih i obrazovnih problema u razvoju mladića i djevojaka, (3) Utvrditi potencijalne rizične i zaštitne čimbenike koji moderiraju odnos između ekonomskih poteškoća obitelji i psihosocijalnih problema adolescenata te njihovih obrazovnih ishoda, (4) Ispitati promjene psihosocijalnih rizika i problema u školskom postignuću tijekom adolescencije, (5) Ispitati obrasce ranog napuštanja srednjoškolskog obrazovanja te steći dublje razumijevanje procesa i čimbenika koji vode ka napuštanju srednje škole.Učenike će se pratiti u tri točke mjerenja (I, II i III razred). Koristiti će se dvo-etapni neproporcionalno stratificirani klaster uzorak koji će obuhvatiti približno 1200 srednjoškolaca i njihovih majki/skrbnica. Istraživanje će se provesti u 6 županija središnje Hrvatske različitog ekonomskog statusa. Metodom namjernog uzorka bit će odabrano 40 učenika iz početnog uzorka koji su u promatranom razdoblju napustili srednjoškolsko obrazovanje. Ishodi projekta će se moći iskoristiti za daljnje razvijanje mjera socijalne i obiteljske politike usmjerenih prema smanjivanju negativnih učinaka ekonomskih teškoća na obitelji, obiteljske odnose i probleme prilagodbe adolescenata.]]></summary_hr><summary_en><![CDATA[Aim of the project is to advance the understanding of effects of family economic hardship on adolescents’ psychosocial and educational problems at a time of a nationwide economic crisis. A new integrative model of impact of family economic hardship (IMFEH) will be tested in a longitudinal quantitative and qualitative research design. The objectives are: (1) To assess the overall and individual contribution of predictors in IMFEH on adolescents&#39; psychosocial development, where internalized problems, externalized problems, other risk behaviours (alcohol and drug abuse, gambling, risk sexual behaviours) and educational outcomes, including dropp-out, will serve as criterion variables, (2) To compare the efficiency of two models – initial family stress model (FSM) and new IMFEH – in predicting psychosocial and educational problems in the development of male and female adolescents, (3) To identify potential risk and protective factors that moderate the relationship between family economic hardship and adolescents&#39; psychosocial problems and educational outcomes, (4) To investigate the changes in psychosocial risks and school achievement problems during adolescence, and (5) To explore patterns of early leaving secondary education and gain deeper understanding of the process and factors that lead to dropping out of secondary school. Pupils will be followed through 3 waves of data collection (1st, 2nd and 3rd grade). A two-stage disproportionally stratified cluster sample, which will include approximately 1200 pupils and their female caretakers, will be used. The research will be conducted in 6 counties that differ in economic development. 40 adolescents from the initial sample who have dropped out of school during the duration of the study will be recruited. The outcomes of the project will be used to advance the social and family policy measures aimed at reducing the negative effects of family economic hardship on family relations and adolescent adjustment problems.]]></summary_en></project><project>
<id>3351</id><title_hr><![CDATA[Razumijevanje, praćenje i analiziranje transparentnosti proračuna lokalnih jedinica: Primjer Hrvatske i Slovenije - Indeks otvorenosti lokalnih proračuna]]></title_hr><title_en><![CDATA[Understanding, monitoring and analysing local government budget transparency:  Case study of Croatia and Slovenia - Open local budget index]]></title_en><user_id>13372</user_id><user_firstLast_name>Katarina Ott</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-3008</code><acronim><![CDATA[OLBI]]></acronim><duration>01.09.2015 - 31.08.2019</duration><status>Završio</status><financ_value>48.857,38 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, </scie_field_hr><scie_field_en>Economy, </scie_field_en><institution_hr><![CDATA[Institut za javne financije]]></institution_hr><institution_en><![CDATA[Institute of Public Finance]]></institution_en><team_members_id>2677, 2754, 13295, 21290, 25362, </team_members_id><team_members_names><![CDATA[Mihaela Bronić, Maja Klun, Velibor Mačkić, Branko Stanić, Simona Prijaković, ]]></team_members_names><keywords_hr><![CDATA[Local government, budget transparency, Open local budget index, Croatia, Slovenia]]></keywords_hr><keywords_en><![CDATA[lokalne jedinice, transparetnost proračuna, Indeks otvorenosti lokalnih proračuna, Hrvatska, Slovenija]]></keywords_en><summary_hr><![CDATA[Transparentnost proračuna lokalnih jedinica (TPLJ) od iznimne je važnosti budući da odluke lokalnih vlasti o trošenju javnih sredstava utječu na svakog građanina.  TPLJ označava u kojoj mjeri i koliko jednostavno građani mogu pristupati informacijama o prihodima i rashodima lokalnih proračuna. Transparentnost proračuna prvi je korak prema demokratizaciji proračunskog procesa i uključivanju građana u oblikovanje politika  i raspodjelu sredstava. Netransparentan proračun ne može se valjano analizirati, njegova se provedba ne može u potpunosti pratiti, niti se mogu vrednovati njegovi ishodi. Unatoč važnosti TPLJ-a, rijetka su istraživanja o njenim mjerenjima, uzrocima i posljedicama. Naš cilj je popuniti tu prazninu u literaturi istražujući: TPLJ u Hrvatskoj i Sloveniji, način na koji se ona mijenja tijekom vremena i razloge zbog kojih su neki lokalni proračuni transparentniji od drugih. Također ćemo nastojati odgovoriti na pitanja utječe li TPLJ na proračunske ishode u izbornim godinama, djeluje li na izborne rezultate i utječu li promjene TPLJ-a tijekom vremena na preferencije političara na vlasti i glasača u vezi s proračunskim ishodima. Oslanjajući se na postojeću literaturu i naše prijašnje radove, cilj nam je postaviti temelj za buduće istraživanje TPLJ-a, čiji će rezultat biti Indeks otvorenosti lokalnih proračuna (IOLP). Najprije ćemo uskladiti i prilagoditi već postojeću hrvatsku metodologiju (Ott, Bronić i Petrušić, 2013.; 2014.), kako bi se  mogla kontinuirano i na isti način primjenjivati na godišnjoj razini u Hrvatskoj i Sloveniji. Budući da će ovo  biti prvi put da se empirijski mjeri i prati TPLJ za prilično dugo razdoblje u dvije zemlje i budući da osim našeg rada (Ott, Bronić i Petrušić, 2013, 2014) nismo uspjeli naći niti jedan drugi rad o uzrocima i posljedicama TPLJ, naš kontinuirani projekt  će predstavljati jedinstven doprinos literaturi. Omogućit ćemo i donošenje boljih politika te veće sudjelovanje građana u odlučivanju o lokalnim proračunima. ]]></summary_hr><summary_en><![CDATA[Local government budget transparency (LBT) is of extreme importance as local authorities’ decisions upon spending public money have an impact on each and every citizen. LBT refers to how easily and to what extent citizens can access information on local government revenues and expenditures. Transparent budgets are a first step toward democratizing the budget process and giving citizens a say in policy formulation and resource allocation. A non-transparent budget cannot be properly analysed, its implementation cannot be thoroughly monitored nor can its outcomes be evaluated. Despite the importance of LBT, research into its measures, causes and consequences is thin. Our aim is to fill this literature gap and investigate: LBT in Croatia and Slovenia, how it changes over time and why some local budgets are more transparent than others. We will also try to answer: whether LBT affects budget outcomes in election years; whether it affects election outcomes and whether its changes over time influence incumbents&#39; and voters’ preferences regarding budget outcomes. Building upon the existing literature and our previous works, the aim is to construct the basis for future research into LBT, resulting in an open local budget index (OLBI). We will first harmonize and adapt the already existing Croatian methodology (Ott, Bronić and Petrušić, 2013; 2014) so that it can be further continually, annually applied in the same way in Croatia and Slovenia. Since this will be the first time that LBT will be empirically measured and monitored for a fairly long period of time in two countries, and since except for our own work (Ott, Bronić and Petrušić, 2013; 2014) we could find no other papers dealing with the causes and consequences of LBT, our continuous research will represent a unique contribution to the existing literature. Our results will also enable better policy-making and greater citizens’ participation in local budget deliberations.  ]]></summary_en></project><project>
<id>3352</id><title_hr><![CDATA[Mikrobna ekologija voda kao pokazatelj zdravstvenog stanja okoliša ]]></title_hr><title_en><![CDATA[Aquatic microbial ecology as an indicator of the health status of the environment]]></title_en><user_id>5800</user_id><user_firstLast_name>Damir Kapetanović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-3494</code><acronim><![CDATA[AQUAHEALTH ]]></acronim><duration>25.11.2015 - 24.11.2019</duration><status>Završio</status><financ_value>122.079,50 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Veterinarska medicina, </scie_field_hr><scie_field_en>Veterinary medicine, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>6257, 5426, 5427, 12841, 5702, 5780, 19037, 119, 21141, 25086, 19718, 25088, 23487, </team_members_id><team_members_names><![CDATA[Irena Vardić Smrzlić, Ana Gavrilovic, Jurica Jug-Dujaković, Dražen Knežević, Darija Vukić Lušić, Kristina Pikelj, Jakov Žunić, Lorena Perić, Anamarija Kolda, Semir Loncarevic, Eddy Listeš, Atle  Lillehaug, Brigita Hengl, ]]></team_members_names><keywords_hr><![CDATA[bakterija, rezistencija, mikrobna ekologija, riba, kvaliteta vode, sediment, zdravlje ljudi]]></keywords_hr><keywords_en><![CDATA[bacteria, resistance, microbial ecology, fish, water quality, sediment, human health]]></keywords_en><summary_hr><![CDATA[Većina studija o mikrobnoj ekologiji vodenog okoliša usredotočena je na odvojene dijelove vodenog ekosustava. našim projektom predlažemo opsežnu studiju bakterijske zajednice u vodenom stupcu, sedimentu i ribama kao pokazateljima zdravstvenog stanja vodenog okoliša i njegovih mogućih implikacija na ljudsko zdravlje. Projektom se nastoji istražiti genetsku raznolikost bakterijskih izolata u vodenom okolišu, od površine do dna, odnose između izolata iz okoliša, onih iz zdravih riba i onih iz riba s kliničkim simptomima bolesti. Ovi podaci su neophodni za predviđanje nastanka i putova širenja bakterijskih pokazatelja kvalitete vode, kao i potencijalno patogenih bakterija, kako za ribe, tako i za ljude. Istražit će se profili rezistencije na antimikrobne lijekove, kako bi se utvrdilo potencijalnu vezu između odabranih modelnih bakterija i njihove rezistencije te učinak različitih uzročnika stresa iz okoliša. Cjelokupna strategija radnog plana je primijeniti multidisciplinarni pristup za istraživanje složenog bakterijskog ekosustava u vodenom okolišu (vidi Sliku 1). Unutar trenutnog partnerstva, četiri zadatka su identificirana, za rješavanje specifičnih problema u vezi s mikrobnom ekologijom vodenog okoliša: 1. Plan i obrazloženje uzorkovanja, 2. Ribe kao modelni organizmi, 3. Odabrane modelne bakterije i 4. Utjecaj na zdravlje ljudi. Istraživanje će se provesti korištenjem infrastrukture i stručnosti prisutne u okviru konzorcija. Projekt će okupiti state of the art istraživanja iz trenutno fragmentiranih područja. Ovo će stvoriti osnovu za daljnje djelovanje u prevenciji bolesti i poremećaja zdravlja riba zbog djelovanja uvjetno patogenih bakterija. Poboljšana održivost okoliša će poboljšati ukupnu ekonomsku održivost sektora akvakulture. To će biti od velikog interesa za širu javnost, proizvođače, potrošače riba i ribljih proizvoda, kao i kreatore i izvršitelje zakona.]]></summary_hr><summary_en><![CDATA[The majority of studies in aquatic microbial ecology focus on the separate segments of aquatic ecosystem. Our project proposes comprehensive study of bacterial community within water column, sediment and fish as indicator of the aquatic environmental health status and its potential implications to human health. The project seeks to understand the genetic diversity of bacterial isolates in the aquatic environment, the relationships between environmental isolates, those from the healthy fish and from fish with clinical symptoms. These data are necessary to predict the origin and spreading pathways of bacterial indicators of water quality, as well as potentially pathogenic bacteria, both for fish and humans. Antibiotic resistance profiles will be explored to determine a potential link between selected model bacteria and their resistance, and the effects of different environmental stress factors. The overall strategy of the work plan is to implement a multidisciplinary approach for the examination of the complex bacterial ecosystem in the aquatic environment. Within the partnership, four tasks have been identified, equating to resolving of specific problem connected with aquatic microbial ecology: 1. Sampling network design and rationale, 2. Fish as model organisms, 3. Selected Model Bacteria and 4. Impact on human health. Research will be carried out using the infrastructures and expertise present within the consortium. The project will bring together state of the art research from currently fragmented research fields in the same area. This will create a basis for further actions in the prevention of diseases and disorders in fish caused by potential pathogens. Improved environmental sustainability will enhance the overall economical viability of the aquaculture sectors, concerned with lowering environmental impacts resulting from current practices. This will be of high interest to the general public, fish consumers, policy makers and policy administrators.]]></summary_en></project><project>
<id>3353</id><title_hr><![CDATA[Razvoj održivog procesa prerade antitoksina ]]></title_hr><title_en><![CDATA[Development of sustainable antitoxin downstream processing]]></title_en><user_id>102</user_id><user_firstLast_name>Beata Halassy</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-4915</code><acronim><![CDATA[ANTI TOX NEW]]></acronim><duration>15.09.2015 - 14.02.2020</duration><status>Završio</status><financ_value>131.661,03 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Biotehnologija, </scie_field_hr><scie_field_en>Biotechnology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu]]></institution_hr><institution_en><![CDATA[University of Zagreb]]></institution_en><team_members_id>1144, 12959, 13090, 17755, 25068, </team_members_id><team_members_names><![CDATA[Tihana Kurtović, Maja Lang Balija, Julija Erhardt, Dora Sviben, Sanja Mateljak Lukačević, ]]></team_members_names><keywords_hr><![CDATA[antitoksin, antivenom, proteini plazme, inaktivacija virusa, (Fab&#39;)2 fragmenti]]></keywords_hr><keywords_en><![CDATA[antitoxin, antivenom, downstream processing, virus inactivation, (Fab&#39;)2 fragments]]></keywords_en><summary_hr><![CDATA[Antitoksini su antitijela životinjskog porijekla koja se koriste za liječenje predoziranja lijekovima (digoksin), virusnih infekcija (bjesnoća), neutralizaciju bakterijskih toksina (difterija, tetanus, botulizam), i liječenje posljedica ugriza životinja životinja otrovnica (zmija, paukova, škorpiona). Antitoksini se proizvode imunizacijom životinja, većinom konja i ovaca, odgovarajućim antigenom (uzvodni dio procesa), i pročišćavanjem imunoglobulina iz hiperimune životinjske plazme (nizvodni dio procesa). Održiv proces prerade životinjskih antitoksina ima i dodatnu vrijednost kao platforma za brzu proizvodnju lijekova protiv potpuno novih bolesti (npr. ebola). Cilj istraživanja je dizajnirati i pronaći optimalne uvjete za najučinkovitiji i najkompaktniji proces pročišćavanja antitoksina na bazi postojećih znanstvenih i tehnoloških dosega. Proces ćemo dizajnirati balansirajući između rastućih regulatornih zahtjeva, iskorištenja procesa (što viši) i troškova pročišćavanja (što niži). Cilj je pronaći optimalne uvjete za svaki korak pročišćavanja, istražiti učinkovitost cijelog postupka u redukciji rizika od virusne kontaminacije, i prikupiti podatke na laboratorijskoj razini koji mogu biti baza za proračune prilikom donošenja odluke za uspostavu pogona održive proizvodnje antitoksina. Istraživat ćemo po prvi put primjenjivost istovremenog taloženja i pepsinske razgradnje konjske plazme, što je pokazano za plazmu ovaca, i učinkovitost navedenog koraka u redukciji rizika od virusne kontaminacije, što još nije istraživano. Također, po prvi puta istražit ćemo primjenjivost kromatografije na monolitnim nosačima u postupcima pročišćavanja antitoksina.]]></summary_hr><summary_en><![CDATA[Antitoxin is the general name for the antibodies of animal origin used to treat for example drug overdose (digoxin), bacterial toxins (diphtheria, tetanus and botulism), viral infections (rabies) and envenoming (snake, spider and scorpion). So antitoxins are produced by immunisation of animals, mostly horse and sheep, by appropriate antigen of interest (upstream part of the process), and subsequent purification of induced immunoglobulins from the hyperimmunised animal plasma (downstream part of the process). Established cost-effective antitoxin production has an additional value serving as a platform that can be easily adapted for fast production of therapeutics to combat new emerging diseases (ebola, for example).The aim of the here proposed research is to design and optimise at the laboratory scale the most effective and most compact purification process (downstream part) based on the current scientific and technological knowledge. The process will be designed by balancing between criteria for fulfilling the growing regulatory demands, purification process yields (as high as possible) and the production costs (as low as possible). The aim is to find the optimal parameters of each purification step, to investigate the effectiveness of the designed process in reducing the risk of viral contamination, and to generate data on laboratory scale that could serve as the basis for decision making process regarding the sustainable antitoxin production plant establishment. The project will investigate for the first time the applicability of single-step simultaneous caprylic acid precipitation and peptic digestion of horse plasma, demonstrated so far only in ovine IgG purification, and the capability of this step in reducing the risk of viral contamination, that has not been investigated yet. Further on, the applicability of monolithic chromatographic supports (convective interaction media) in the process of antitoxin purification will be explored for the first time.]]></summary_en></project><project>
<id>3359</id><title_hr><![CDATA[Fleksigurnost i novi oblici rada (izazovi modernizacije hrvatskog radnog prava)]]></title_hr><title_en><![CDATA[Flexicurity and New Forms of Employment (Challenges regarding Modernization of Croatian Labour Law) ]]></title_en><user_id>5784</user_id><user_firstLast_name>Sandra  Laleta</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2014-09</proposal_call><code>UIP-2014-09-9377</code><acronim><![CDATA[FLEKSINORA]]></acronim><duration>01.07.2015 - 30.06.2018</duration><status>Završio</status><financ_value>38.292,22 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Pravo, </scie_field_hr><scie_field_en>Law, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Pravni fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Law]]></institution_en><team_members_id>413, 5585, 5762, 13639, 13680, 13558, 13698, 13714, 13601, 5231, 13716, 13757, 13702, </team_members_id><team_members_names><![CDATA[Vanja Smokvina, Ana Pošćić, Adrijana Martinović, Ivana  Vukorepa, Hießl Christina, anna zilli, marina  brollo, ANDRIJANA BILIĆ, Laura Calafa, Nada Bodiroga-Vukobrat, Darja Senčur Peček, Gerald G. Sander, Ivana Grgurev, ]]></team_members_names><keywords_hr><![CDATA[radno pravo, Hrvatska, fleksigurnost, oblici rada, reforma, ]]></keywords_hr><keywords_en><![CDATA[labour law, Croatia, flexicurity, forms of employment, reform]]></keywords_en><summary_hr><![CDATA[Očekivani rezultati Projekta jesu prijedlozi de lege ferenda (modeli) koji će biti razvijeni i testirani za vrijeme trajanja Projekta. Rezultati će se javno objaviti i diseminirati kroz izvješća i objavljivanjem u inozemnoj i domaćoj literaturi (dostupni sažetak spoznaja do kojih se došlo tijekom istraživanja bit će dostupan kreatorima politika, te znanstvenoj, stručnoj i široj javnosti),  te na konferencijama i kroz znanstvene članke. Rezultati Projekta temeljit će se na sljedećim ciljevima: utvrđivanje inicijative u predmetnom području, utvrđivanje prednosti i nedostataka važećeg regulatornog okvira te utvrđivanje postojećeg stanja,  kao polazišta za sljedeću fazu istraživanja; prijedlog / razvijanje novog regulatornog okvira (modela) u Hrvatskoj i razmjena iskustva i dobrih praksi.]]></summary_hr><summary_en><![CDATA[The outcomes / expected results of this Project will be new de lege ferenda models developed and tested during the course of the Project intended to be implemented in Croatia. The outcomes / results will be made publicly visible and disseminated in a report and in written materials in international and domestic literature (an accessible summary of the findings aimed at policy makers and at scientific, professional and wide public), along with conference presentation and papers. The Project’s outcomes / results will be based upon the following Project objectives: Mapping of initiatives in the area of research interest; determining the pros and cons of the actual regulatory framework in line to highlight the state of facts, and to form the base for the next research stages; proposing / developing of new regulatory framework (models) in Croatia and exchange of experience and best practices.]]></summary_en></project><project>
<id>3362</id><title_hr><![CDATA[Algoritmi za mjerenje sustavskog rizika]]></title_hr><title_en><![CDATA[Algorithms for Systemic Risk Measurement]]></title_en><user_id>13406</user_id><user_firstLast_name>Zvonko Kostanjčar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2014-09</proposal_call><code>UIP-2014-09-5349</code><acronim><![CDATA[ASYRMEA]]></acronim><duration>01.10.2015 - 30.09.2018</duration><status>Završio</status><financ_value>65.565,07 eur</financ_value><scie_area_hr>Tehničke znanosti, Prirodne znanosti, Društvene znanosti, </scie_area_hr><scie_area_en>Technological sciences, Natural sciences, Social sciences, </scie_area_en><scie_field_hr>Elektrotehnika, Matematika, Fizika, Računarstvo, Ekonomija, </scie_field_hr><scie_field_en>Electrical engineering, Mathematics, Physics, Computer sciences, Economy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>13519, 7322, 6508, 5624, 21046, 23106, </team_members_id><team_members_names><![CDATA[Kristian Hengster Movric, Branko Jeren, Dražen Jurišić, Boris Podobnik, Stjepan Begušić, Mate Puljiz, ]]></team_members_names><keywords_hr><![CDATA[sustavski rizik, kompleksni sustavi, mrežna dinamika, rijetkost, vremenski diskretni signali]]></keywords_hr><keywords_en><![CDATA[systemic risk, complex systems, network dynamics, sparsity, discrete time signals]]></keywords_en><summary_hr><![CDATA[Razmatramo kompleksni sustav, poput nuklearne elektrane, koji je građen od velikog broja podsustava s određenom vjerojatnošću kvara koje nisu nezavisne. Zanima nas vjerojatnost kvara cijelog sustava koji se događa kad neki podskup podsustava zakaže, tj. zanima nas sustavski rizik. Kako možemo modelirati takvu situaciju i procijeniti sustavski rizik? Na žalost, to je vrlo teško i nismo dobri u tome, pa tako npr. red veličine vjerojatnosti kvara neke nuklearne elektrane još uvijek nije poznata. Čini se da je to zato što je većina poznatih korelacijskih struktura u vjerojatnosti nisko dimenzionalna ili čak jednodimenzionalna. Međutim, u kompleksnim sustavima su korelacijske strukture visoko dimenzionalne i obično ne vrijedi pretpostavka nezavisnosti. Cilj ovog istraživačkog projekta je pronaći učinkovite algoritme za mjerenje sustavskog rizika definiranjem novih klasa modela višedimenzionalnih korelacijskih struktura u velikom skupu slučajnih varijabli. Definirani modeli moraju biti računalno izvedivi i dovoljno jednostavni da im se parametri mogu estimirati iz podataka u različitim primjenama višedimenzionalne analize podataka.U ovom projektu ćemo nastaviti koristiti metode matematičkog i računalnog modeliranja, konkretno: kompleksnih mreža, rijetkih estimacija i koncentracije mjere. Koristeći ovaj pristup smo već postigli vrlo važne rezultate, poput uvida u nastajanje zakona potencija i dvofaznog ponašanja u fluktuacijama financijskih tržišta. Također bismo s ovim pristupom željeli bolje razumjeti sustavski rizik i stabilnost kompleksnih sustava (npr. financijskog sustava). Potreba za znanstveno utemeljenom mjerom sustavskog rizika nije samo akademska zato što se diljem svijeta pokušava smanjiti rizik i troškovi sustavskih kriza.]]></summary_hr><summary_en><![CDATA[Consider a complex system (such as a nuclear plant) that is made from many subsystems which themselves have certain probabilities of failure, and these probabilities are not independent. Suppose that we are interested in the probability of failure of the entire system, failure that occurs when certain subset of the subsystems fail, i.e. we are interested in the systemic risk. How do we model such a situation and estimate the systemic risk? Unfortunately, this is very difficult, and we are not very good at it, e.g. the order of magnitude of the probability of failure of a nuclear plant is still ungraspable. It seems that this is because most of the familiar correlation structures in probability are low-dimensional, or even one-dimensional. However, correlation structures in complex systems are high-dimensional and usual independence assumption is seriously violated. The goal of this research project is to find efficient algorithms for systemic risk measurement by defining a new class of models of high-dimensional correlation structures in a large collection of random variables. The defined models should be computationally tractable and simple enough so that one can bring them to data and use it for various applications in high-dimensional data analysis.In this project we will continue to use the methods of mathematical and computational modeling, specifically: complex networks, sparse estimation, and concentration of measure. With this approach, we have already obtained very important results, like an insight into the emergence of power-law and two-phase behavior in the financial market fluctuations. Also, with this approach we would like to better understand the basic mechanisms that underlie systemic risk and the stability of the complex systems (e.g. financial system). The need for scientific foundations for a systemic risk measure is more than an academic concern as different people around the world consider how to reduce the risks and costs of systemic crises.]]></summary_en></project><project>
<id>3363</id><title_hr><![CDATA[Sinteza, strukturna analiza i biološka evaluacija peptidomimetika i glikokonjugata ]]></title_hr><title_en><![CDATA[Synthesis, Structural Analysis and Biological Evaluation of Peptidomimetics and Glycoconjugates]]></title_en><user_id>569</user_id><user_firstLast_name>Srđanka Tomić-Pisarović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-7899</code><acronim><![CDATA[PEPTGLYCOSAR]]></acronim><duration>01.06.2015 - 31.05.2019</duration><status>Završio</status><financ_value>97.285,82 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>300, 484, 485, 1146, 492, 3573, 5587, 5597, 5505, 3493, 23983, </team_members_id><team_members_names><![CDATA[Lidija Barišić, Rosana Ribić, Željka Car, Teuta Opačak-Bernardi, Vesna Petrović Peroković, Krešimir Baumann, Mojca Čakić Semenčić, Monika Kovačević, Veronika Kovač, Đani Škalamera, Marija Paurević, ]]></team_members_names><keywords_hr><![CDATA[peptidomimetici, peptidoglikan, feroceni, manokonjugati, bioaktivnost]]></keywords_hr><keywords_en><![CDATA[peptidomimetics, peptidoglycan, ferrocenes, mannoconjugates, bioactivity]]></keywords_en><summary_hr><![CDATA[Osnovni cilj ovog projektnog prijedloga je sinteza, strukturna analiza i biološka evaluacija dvije vrste novih peptidomimetika: (i) peptidnih spojeva peptidoglikanskog tipa s imunomodulacijskim djelovanjem, u svrhu ispitivanja njihove interakcije sa specifičnim receptorima te (ii) peptidnih konjugata s ferocenom, s kiralno organiziranim strukturama ostvarenima povezivanjem intramolekulskim vodikovim vezama, a koje su preduvjet za stvaranje 3D struktura i funkcioniranje bioloških sustava. Također će se pripraviti glikokonjugati tih spojeva te će se proučavati njihova biološka svojstva. Naglasak će biti na manokonjugatima obzirom da je to jedan od monosaharida kojeg prepoznaju specifični receptori na površini stanica. Manozilirani peptidoglikanski fragmenti s adamantanskom podstrukturom ugrađivati će se u liposome na način da manozne jedinice budu na njihovoj površini kako bi bile dostupne za manozne receptore na stanicama imunološkog sustava. Sljedeći je cilj ovog projektnog prijedloga sinteza peptidoglikanskih fragmenata s ugrađenom ferocenskom podjedinicom te pručavanje konformacija tih molekula. Ferocenski alfa-manozidi ispitat će se pomoću testa inhibicije hemaglutinacije kao potencijalni inhibitori infekcije koju uzrokuje Escerichia coli. Ova istraživanja proširit će se i na alfa-manozide heterocikličkih spojeva kao što su 3-hidroksipiridin-4-oni, imidazolijevi i benzimidazolijevi derivati, koji su česti sastavni dijelovi spojeva sa širokim spektrom bioloških djelovanja. Biološka evaluacija svih pripravljenih spojeva ovog projektnog prijedloga provoditi će se, jednim svojim dijelom, u suradničkim institucijama u svrhu korelacije struktura derivata s njihovom biološkom aktivnošću. Studije molekulskog modeliranja koristit će se za predviđanje strukturnih promjena u svrhu poboljšanja aktivnosti.]]></summary_hr><summary_en><![CDATA[In this project proposal the main goal is the synthesis, structural characterization and biological evaluation of novel peptidomimetics of two types: (i) peptidoglycan derived peptides possessing immunomodulating activity in order to study their interactions with specific receptors and (ii) ferrocene-peptide conjugates which comprise an efficient bioorganometallic constraint designed to induce chirally organized structures through intramolecular hydrogen bonding as a prerequisite for 3D structure formation and function of biological systems. Glycoconjugates of these compounds will be prepared and their biological properties studied with emphasis on mannoconjugates since mannose is one of the carbohydrates recognized by receptors on cell surfaces. Mannosylated peptidoglycan fragments with the adamantane moiety will be incorporated into liposomes with mannose exposed at the surface serving in targeting mannose receptors on immune cells. Furthermore, peptidoglycan fragments will be modified with the ferrocenyl moiety and their conformational properties studied. Alpha-mannoside derivatives of these compounds will be also investigated as possible inhibitors of infections caused by Escerichia coli using the hemagglutination test. These studies will be extended to alpha-mannoside derivatives of heterocyclic compounds such as 3-hydroxypyridine-4-ones, imidazoles and benzimidazoles which are common parts of substances with a broad spectrum of biological activities. Screening and evaluation of biological properties of all compounds to be synthesized will be performed, partly in collaborative institutions. Molecular modelling will be used in predicting structural changes leading to improved biological activities. ]]></summary_en></project><project>
<id>3367</id><title_hr><![CDATA[Programski sustav za paralelnu analizu više heterogenih nizova vremenskih podataka s primjenom u biomedicini]]></title_hr><title_en><![CDATA[A software system for parallel analysis of multiple heterogeneous time series with application in biomedicine]]></title_en><user_id>12928</user_id><user_firstLast_name>Alan Jović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2014-09</proposal_call><code>UIP-2014-09-6889</code><acronim><![CDATA[MULTISAB]]></acronim><duration>01.10.2015 - 30.09.2018</duration><status>Završio</status><financ_value>53.799,19 eur</financ_value><scie_area_hr>Tehničke znanosti, Biomedicina i zdravstvo, </scie_area_hr><scie_area_en>Technological sciences, Biomedicine and health sciences, </scie_area_en><scie_field_hr>Računarstvo, Kliničke medicinske znanosti, Javno zdravstvo i zdravstvena zaštita, </scie_field_hr><scie_field_en>Computer sciences, Clinical sciences, Public health and health services, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>12932, 12925, 12920, 12750, 18915, </team_members_id><team_members_names><![CDATA[Krešimir Jozić, Car Siniša, Marko Horvat, Marko Velić, Mario Cifrek, ]]></team_members_names><keywords_hr><![CDATA[vremenski nizovi, obrada biomedicinskih signala, nelinearna dinamika, ekspertni sustav, klasifikacijski model, umjetna inteligencija]]></keywords_hr><keywords_en><![CDATA[time series, biomedical signal processing, nonlinear dynamics, expert system, classification model, artificial intelligence]]></keywords_en><summary_hr><![CDATA[Zadatak analize vremenskih nizova jest otkrivanje i klasifikacija značajnih obrazaca ponašanja u podacima koji sadrže vremensku komponentu. Ovaj projekt bavit će se razvojem cjelovitog programskog sustava koji uključuje opće i domenske značajke vremenskih nizova, i primjenjuje ih u biomedicini. Cilj projekta je razviti učinkovit i nadogradiv sustav za automatsku klasifikaciju poremećaja rada ljudskog organizma na temelju analize više heterogenih biomedicinskih signala (srčani ritam, EKG, EEG i dr.). Uz izradu klasifikacijskih modela, predviđa se razvoj vizualizacije poremećaja uporabom računalne grafike. Radi povećanja brzine, koristit će se paralelna obrada u višejezgrenom režimu rada. Sustav će objedinjavati podsustavi za: 1) odabir, prikaz i prilagođavanje zapisa jednog ili više ulaznih signala, 2) paralelnu obradu i izlučivanje više domenskih i općih značajki signala, 3) vizualizaciju signala i poremećaja korištenjem računalne grafike i 4) automatsku izgradnju i završno vrednovanje modela. Za vrednovanje će se koristiti referentne internetske baze zapisa biomedicinskih signala s portala PhysioNet te, po mogućnosti, anonimizirani zapisi iz lokalnih bolnica. Jedan od doprinosa sustava bit će ekspertni podsustav za automatsko predlaganje skupa značajki koje se trebaju izlučivati. Opće značajke signala koje će se implementirati uključivat će relevantne značajke nelinearne dinamike za karakterizaciju jednog ili više signala. Specijalizirane, domenske značajke implementirat će se za svaku vrstu biomedicinskog signala zasebno. Pri izgradnji modela poremećaja, provest će se smanjenje dimenzionalnosti prostora značajki. Model poremećaja gradit će se na temelju algoritama jasnog opisa kao što su klasifikacijska pravila i na temelju algoritama za postizanje najveće točnosti kao što su ansambli stabala odluke. U okviru ovog interdisciplinarnog projekta, očekuje se više doprinosa u područjima računarske znanosti, biomedicinskog inženjerstva i medicine.]]></summary_hr><summary_en><![CDATA[The task of time series analysis is to discover and classify significant patterns in data that contain a temporal component. This project deals with development of an integrated software system that includes general and domain specific time series features, with application in biomedicine. The goal of the project is to develop an efficient and upgradeable system for automatic classification of human body disorders based on the analysis of multiple heterogeneous biomedical signals (heart rhythm, ECG, EEG, etc.). In addition to classification, the project will also pursue visualization of disorders using computer graphics. Calculation speed will be increased using multicore parallelization. The system will contain subsystems for: 1) selection, display, and pre-processing of multiple signals from input records, 2) parallel analysis and extraction of multiple domain specific and general signal features, 3) visualization of signals and disorders using computer graphics, and 4) automatic construction and evaluation of the models. For evaluation purposes, the project will use referential biomedical signal databases from the PhysioNet portal and, if possible, anonymous records from local hospitals. One of the contributions of the system will be development of an expert subsystem for automatic recommendation of the set of features that should be extracted. The implemented general signal features will include relevant nonlinear dynamics measures. Specialized, domain specific features will be implemented for each type of biomedical signal individually. When constructing disorder models, feature space dimensionality reduction will be pursued. Disorders will be modeled based on clear description machine learning algorithms such as classification rules as well as maximum accuracy algorithms such as decision tree ensembles. Within the scope of this interdisciplinary project, several contributions in the areas of computer science, biomedical engineering, and medicine are expected.]]></summary_en></project><project>
<id>3368</id><title_hr><![CDATA[Jezik izdanja hrvatske protestantske tiskare u kontekstu književnojezičnih smjernica XVI. st.]]></title_hr><title_en><![CDATA[The language of the Urach protestant press editions within context of the 16th century literary language guidelines]]></title_en><user_id>11240</user_id><user_firstLast_name>Mateo Zagar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-6415</code><acronim><![CDATA[JezHrvProt]]></acronim><duration>01.10.2015 - 30.09.2019</duration><status>Završio</status><financ_value>20.277,39 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filologija, </scie_field_hr><scie_field_en>Philology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>2586, 1236, 13568, 24332, </team_members_id><team_members_names><![CDATA[Ivana Eterović, Tanja Kuštović, Stjepan Damjanović, Vera Blažević Krezić, ]]></team_members_names><keywords_hr><![CDATA[povijest hrvatskog jezika, glagoljica, ćirilica, latinica, hrvatska protestantska književnost]]></keywords_hr><keywords_en><![CDATA[history of croatian language, glagolitic alphabet, cyrillic alphabet, latin alphabet, literature of croatian protestants]]></keywords_en><summary_hr><![CDATA[Ovaj je projekt osmišljen kao temeljit opis jezičnog stanja u hrvatskim izdanjima protestantske tiskare iz Uracha (glagoljicom, ćirilicom i latinicom, 1555, 1561-1565, 1568). Važnost temeljite obrade ovoga korpusa počiva na dinamičnosti prijelomnih zbivanja u koncipiranju jezika hrvatske knjige u XVI. st, iznimno važnom razdoblju kada se, na temelju urušenog srednjovjekovnog ustroja „trostruko artikuliranog“ književnog jezika (ovisno o tekstnim funkcijama) i uspostavljene diglosije (Ferguson 1959, Corin 1993), a prije razrade čvrste jezične politike u posttridentskoj ranonovovjekovnoj Europi kojom će početi tzv. protostandardizacijsko razdoblje hrvatskoga jezika, u tiskanoj glagoljskoj knjizi nastoji promovirati jedinstven jezik. Premda je dosad bilo vrlo vrijednih pokušaja opisa jezika ovoga korpusa taj je posao obavljen ili starijom metodologijom (F. Fancev, 1916), ili tek na manjem dijelu korpusa (Damjanović 2010, 2011; Čupković 2010, 2013). Posljednjih desetak godina stvorene su dobre pretpostavke da se novom metodologijom potpuno opiše ova dionica jezične povijesti: objavljeni su mnogi pretisci, od kojih najveće djelo Novi testament (1562, 1563) i u latiničkoj transliteraciji (2013); provedena je temeljita komparativna analiza Misala hruackoga Š. Kožičića Benje (1531) i prethodnih triju tiskanih hrvatskoglagoljskih misala. Cilj je ovog projekta objaviti transliteracije i nekih drugih uraških glagoljičkih izdanja (prije svega Katekizma, Postile, Artikula), i to usporedbeno sa stanjem u paralelnim ćiriličkim i latiničkim izdanjima, te provesti analizu na svim jezičnim razinama, osobito na sintaktičkoj i leksičkoj. Novu metodologiju odlikuje odustajanje od dominacije dijakronijske perspektive, te usmjeravanje na sinkrono koncipiranje jezika unutar kojega se kombiniraju jezični elementi iz sva tri hrvatska narječja te elementi crkvenoslavenskoga jezika.]]></summary_hr><summary_en><![CDATA[      The project has been devised to describe in detail the language condition of Croatian editions printed at the Protestant press in Urach (in Glagolitic, Cyrillic and Latin, 1555, 1561-1565, 1568). The significance of the thorough analysis of corpus in question lies in the dynamics of the crucial moments that determined the outline of the16th century Croatian literary language. That particular period, between the collapsed medieval system of ‘triple articulation’ literary language (depending on the text functions) and the established diglossia (Ferguson 1959, Corin 1993), but before the development of the firm language policy in Post-Tridentine Early Modern Age Europe which signified the beginning of the so-called proto-standardisation era of the Croatian language, is very important in the attempt to promote the uniform language of printed Glagolitic texts.The previous noteworthy attempts to describe the corpus language (17 editions in three scripts, c. 2000 folios in Glagolitic only) were executed using either the obsolete methodology (F. Fancev, 1916) or the smaller sample (Damjanović 2010, 2011; Čupković 2010, 2013). In the past ten years, the new methodology has provided a strong groundwork for full description of that division of language history; reprints were published, the most important of which is The New Testament (1562, 1563) in Latin transliteration (2013); a comprehensive comparative analysis of Kožičić’s Misal hruacki (1531) and the three previously printed Croato-Glagolitic missals were conducted. The project’s objective is the publishing of transliterations and other selected Glagolitic editions from Urach  in comparison with parallel Cyrillic and Latin editions, as well as conducting analysis at all language levels. The new methodology abandons the diachronic perspective domination and is directed towards a synchronic approach in combining the language elements of all three Croatian dialects as well as those of the Church Slavonic language.]]></summary_en></project><project>
<id>3372</id><title_hr><![CDATA[Utjecaj akvakulture na prirodne morske populacije]]></title_hr><title_en><![CDATA[Aquaculture impact on wild marine populations]]></title_en><user_id>3217</user_id><user_firstLast_name>Tanja Šegvić Bubić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-9050</code><acronim><![CDATA[AquaPop]]></acronim><duration>01.09.2015 - 31.10.2019</duration><status>Završio</status><financ_value>106.536,60 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Biotehnologija, </scie_field_hr><scie_field_en>Biotechnology, </scie_field_en><institution_hr><![CDATA[Institut za oceanografiju i ribarstvo]]></institution_hr><institution_en><![CDATA[Institute of Oceanography and Fisheries]]></institution_en><team_members_id>4254, 3600, 6619, 3959, 178, 2850, 18930, 18929, 21299, </team_members_id><team_members_names><![CDATA[Ivan  Katavić, Leon Grubišić, Vjekoslav Tičina, Nika Stagličić, Jasna  Maršić-Lučić, Ivana Radonić, Luka Čulić, Iva  Žužul, Igor Talijančić, ]]></team_members_names><keywords_hr><![CDATA[Akvakultura, utjecaj, prirodne populacije riba i školjkaša, ekološke zamke, prebjezi, genetske interakcije]]></keywords_hr><keywords_en><![CDATA[Aquaculture, Impact, Wild fish and shellfish populations, ecological traps, escapees, genetic interactions]]></keywords_en><summary_hr><![CDATA[Zbog stalnog rasta broja lokacija za uzgoj morskih organizama javlja se sveprisutna zabrinutost da marikultura kao gospodarska djelatnost može predstavljati opasnost za morsku biološku raznolikost kroz negativni utjecaj na prirodne populacije morskih organizama kao i cjelokupni morski ekosustav. Ekološke interakcije se odražavaju kroz činjenicu da kavezne uzgojne instalacije postaju nove ekološke niše za prirodne populacije ribe kod kojih promjene u fiziologiji i ponašanju su moguće. Drugi rizik za okoliš se očituje u mogućem utjecaju zbjegova uzgojne ribe iz kaveza prisutne u morskom okolišu kao rezultat slučajnog bijega iz kaveza ili namjernog poribljavanja. Pobjezi ili poribljavane jedinke iz uzgoja predstavljaju potencijalni rizik genetskoj osnovi izvornih ribljih populacija. Zbog boljeg razumijevanja složenosti  utjecaja akvakulture na prirodne populacije, ovaj projekt će iskoristiti najnovije instrumentalne i genetske pristupe s ciljem podržavanja uzgojnih i upravljačkih aktivnosti, kao i zaštite morskog okoliša. Projekt uključuje: (i) uporabu suvremenog sustava stereoskopske kamere i multivarijatnih analizi indirektnih pokazatelja kondicije s ciljem procjene uloge uzgajališta kao ekoloških zamki divljih ribljih populacija, (ii) korištenje forenzički svojstvenih genetskih alata u procjeni genetske strukture divljih/uzgojnih riba i školjkaša , (iii) uporaba suvremenog genetski-analitičkog pristupa s ciljem određivanja porijekla uzgojnih populacija i utvrđivanja možebitnih genetskih interakcija populacija iz uzgoja s prirodnim/divljim populacijama iste vrste, a na kraju (iv) procjena utjecaja translokacije mlađi kamenica između geografski udaljenih uzgojnih lokacija na genetsku strukturu izvornih populacija kamenice u hrvatskom dijelu Jadrana.Zaključno, predloženi projekt se nadovezuje na zajednički izazov evropske zajednice  koji se očituje u poticanju razvoja održive akvakulture kroz poboljšanje konkurentnosti i ekološki prihvatljive proizvodnje. Kako su potencijalno negativni učinci akvakulture prisutni u svim zemljama EU-a, međunarodna suradnja će se biti prepoznata i implementirana tijekom provedbe projektnih zadataka. Projektni ishodi će biti dostupni svim zainteresiranim strankama odnosno istraživačima, industriji, zakonodavnim tijelima i svim potencijalnim korisnicima.]]></summary_hr><summary_en><![CDATA[Expansion of marine farming sites raised the concern that aquaculture may pose a threat to biodiversity due to detrimental impacts on wild populations and ecosystem. Ecological interactions of farm installations are reflected through  acting as new ecological niches for the local fish where also altered wild fish physiology and behaviour may occur. Another environmental risk is the potential impact of releasing farmed fish into the wild, through accidental escape or deliberate restocking. Escapes or releases of the domesticated aquaculture fish pose a potential risk of adverse effects on native fish gene pools. To better understand the complexity of aquaculture impacts on the native populations, this project will take advantage of cutting edge instrumental and genetic approaches to support aquaculture activity and management, as well as the protection of marine environment. This includes: (i) using novel stereoscopic camera system and multivariable analysis of proxy measure of fitness to asses do farms function as ecological traps for wild fish, (ii) using forensically validated genetic tools to assess genetic structure of wild/farmed fish and shellfish, (iii) using cutting edge genetic analytical approach to trace the origin of farmed fish and to monitor genetic interactions between fish from aquaculture and their wild conspecifics, and finally (iv) validation of the impact of oyster spat translocation between geographically distinct farming locations on genetic structure of native oysters populations in the Croatian part of the Adriatic Sea. Thus, this project addresses the common European challenge to develop sustainable aquaculture through improved competitiveness and environmentally-friendly production. As the potential adverse effects of aquaculture affect all EU countries, international collaboration will be implemented. The outcome of the project will be available to the researchers, the industry, policy makers and the general public.]]></summary_en></project><project>
<id>3389</id><title_hr><![CDATA[Recommender System for Service-oriented Architecture ]]></title_hr><title_en><![CDATA[Sustav predlaganja u arhitekturi zasnovanoj na uslugama]]></title_en><user_id>7793</user_id><user_firstLast_name>Siniša Srbljić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-9606</code><acronim><![CDATA[RSOA]]></acronim><duration>01.09.2015 - 31.08.2018</duration><status>Završio</status><financ_value>84.478,07 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>11194, 12997, 12993, 12998, 22589, 13653, </team_members_id><team_members_names><![CDATA[Goran Delač, Marin Šilić, Klemo Vladimir, Zvonimir Pavlić, Adrian Satja Kurdija, Miroslav Popović, ]]></team_members_names><keywords_hr><![CDATA[sustav preporuke, arhitektura zansnovana na uslugama, kompozicije usluga, pomoć pri programskom oblikovanju, funkcijska i nefunkcijska svojstva]]></keywords_hr><keywords_en><![CDATA[recommender system, service-oriented architecture, service compositions, development assistance, functional and non-functional properties]]></keywords_en><summary_hr><![CDATA[Razvojem platformi vezanih uz računalne oblake (engl. Cloud computing) i internet stvari (engl. Internet of Things), sustavi utemeljeni na arhitekturi zasnovanoj na uslugama (engl. service-oriented architecture - SOA) dobivaju sve više na značaju. SOA je arhitekturalni stil koji pruža smjernice razvoja slabo povezanih raspodijeljenih sustava. Središnji objekt SOA-e su usluge, samostalni primjenski programi, kojima se pristupa korištenjem standardiziranih sučelja. Jedna od glavnih prednosti SOA-e jest mogućnost povezivanja više usluga u kompozitne sustave (kompozicije usluga). Unatoč jasnim prednostima, uz razvoj kompozicija usluga veže se niz poteškoća vezanih uz ostvarivanje funkcijskih i nefunkcijskih svojstava građenog sustava. Trenutni istraživački rezultati ne pružaju odgovor kako učinkovito graditi kompozicije usluga u slučaju kad su dostupni vrlo veliki imenici usluga te kad je složenost tijeka izvođenje građene kompozicije vrlo velika. 	Cilj ovog istraživačkog projekta je izraditi cjelovit sustav preporuke čija je uloga pojednostaviti izgradnju kompozicija usluga pružanjem pomoći programskim inženjerima u ostvarivanju funkcijskih i nefunkcijskih ciljeva. Naši prijašnji istraživački rezultati pokazuju da je izgradnja takvog sustava moguća. Kroz ovaj projekt cilj nam je proširiti postojeće rezultate s novim metodama preporuke posebno prilagođenim sustavima zasnovanima na arhitekturalnom stilu SOA.	U području funkcijskih ciljeva, predloženi sustav preporuke će omogućiti automatsku preporuku usluga zasnovanu na morfološkoj strukturi građene kompozicije usluga. Osim toga, sustav će primjenom tehnologija dijeljenja znanja omogućiti korisnicima da pronađu odgovarajuću ljudsku pomoć. U području nefunkcijskih svojstava, primijenit će se skup statističkih metoda za procjenu pouzdanosti atomarnih (gradivih) usluga. Zaključno, sustav će omogućiti učinkovito unapređivanje nefunkcijskih svojstva izgrađene kompozicije s obzirom na složenost tijeka izvođenja.]]></summary_hr><summary_en><![CDATA[In recent years, systems based on service-oriented architecture (SOA) have been gaining a lot of traction due to proliferation of cloud computing and Internet of Things (IoT) platforms. SOA is an architectural style that provides guidelines for development of loosely coupled distributed systems. The concept relies on services, self-contained applications which can be consumed using well-established interfaces. One of the most pronounced benefits of SOA is the ability to combine multiple services into a component-based application (service composition). Despite having clear advantages, service composition development entails issues when it comes to reaching both the required functional and non-functional application goals. Specifically the current research results do not offer an answer how to build service compositions efficiently when faced with large service repositories and very complex service workflows.	The goal of this project is to put forward a comprehensive recommender system aimed at simplifying development of service compositions by assisting developers in reaching both functional and non-functional application goals. Our previous research efforts, demonstrate that designing such a recommender is feasible. As part of this project we want to extend the preliminary research with novel recommender methods suited for SOA-based systems. Regarding functional properties, the proposed recommender is to facilitate automatic service recommendations based on the morphological structure of the constructed application. Furthermore, the recommender is to utilize knowledge sharing technologies to assist in enlisting most adequate human help. In the domain of non-functional properties, a set of methods used to determine reliability of atomic services based on statistical approaches will be applied. Finally, a method for efficient improvement of service composition’s non-functional properties will be utilized.]]></summary_en></project><project>
<id>3391</id><title_hr><![CDATA[Nove biopolimerne mikrokapsule za kontrolirano otpuštanje tvari za zaštitu/ishranu bilja ]]></title_hr><title_en><![CDATA[New biopolymer based microcapsules for plant protection/nutrition agents controlled release]]></title_en><user_id>736</user_id><user_firstLast_name>Marko Vinceković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2014-09</proposal_call><code>UIP-2014-09-6462</code><acronim><![CDATA[NewBioCap/NoveBioKap]]></acronim><duration>01.09.2015 - 31.08.2018</duration><status>Završio</status><financ_value>44.196,70 eur</financ_value><scie_area_hr>Biotehničke znanosti, Prirodne znanosti, </scie_area_hr><scie_area_en>Biotechnical sciences, Natural sciences, </scie_area_en><scie_field_hr>Poljoprivreda, Kemija, </scie_field_hr><scie_field_en>Agriculture, Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Agronomski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Agriculture]]></institution_en><team_members_id>4407, 7227, 3287, 3131, 5708, 13477, </team_members_id><team_members_names><![CDATA[Edyta Đermić, Marija Bujan, Nenad Jalšenjak, Snježana Topolovec-Pintarić, Ivanka Žutić, Sanja Fabek, ]]></team_members_names><keywords_hr><![CDATA[biopolimeri, simultana mikroinkapsulacija biočimbenika, biološki aktivne tvari, kemijski aktivne tvari, ishrana bilja,]]></keywords_hr><keywords_en><![CDATA[biopolymers,  simultaneous microencapsulation of biofactors, biologically active agents, chemically active substances, plant nutrition]]></keywords_en><summary_hr><![CDATA[Mikrokapsule na bazi biopolimera s inkapsuliranim jednim bioaktivnim agensom imaju široku primjenu u poljoprivredi te su postale jedna od standardnih tehnika. Međutim, znanje o simultanoj inkapsulaciji biološkog i kemijskog agensa je prilično ograničeno. Glavni cilj ovog projekta je istražiti simultanu inkapsulaciju sredstava za  zaštitu/ishranu bilja u biopolimerne mikrokapsule. Specifični ciljevi su: (i) istraživanje molekulskih međudjelovanja u sustavima s biopolimerima suprotnih naboja, (ii) istraživanje novih biopolimernih mikrokapsula, t.j. istraživanje međudjelovanja bioaktivnog agensa i sustava za isporuku,  (iii) istraživanje optimalnih uvjeta za simultano inkapsuliranje biološkog i kemijskog agensa, (iv) laboratorijska istraživanja optimalnih formulacija mikrokapsula i (v) in vivo testiranje optimalnih formulacija mikrokapsula na salati i rajčici u konvencionalnom i  hidroponskom uzgoju.Naša će nastojanja biti usmjerena na istraživanje kitozan/alginat mikrokapsula prikladnih za simultano inkapsuliranje bakra ili kalcija s Trichoderma viride. Predložena istraživanja su interdisciplinarna i provest će se na modelnim sustavima s biopolimerima suprotnih naboja. Istraživanja modelnih sustava, kod kojih je u velikoj mjeri smanjen broj varijabli, pomoći će objasniti međudjelovanja suprotno nabijenih biopolimera i bioaktivnih agensa i dati smjernice za izradu novih formulacija mikrokapsula. U istraživanjima će se koristiti velik broj različitih standardnih i modernih tehnika/metoda. Projekt je u biti fundamentalan, ali je od velike praktične važnosti jer će bolje razumijevanje međudjelovanja  biopolimera i bioaktivnih agensa na molekulskoj razini poslužiti kao podloga za pripravu novih formulacija mikrokapsula za primjenu.]]></summary_hr><summary_en><![CDATA[Biopolymer based microcapsules with a single bioactive agent have extensive applications in agriculture and become one of standard formulation techniques nevertheless our knowledge of simultaneous encapsulation of biological and chemical agents is still rather limited.The main aim of this proposal is to investigate simultaneous encapsulation of protection/nutrition agents in biopolymer based microcapsules. The specific goals are: (i) investigations of intermolecular interactions in systems with biopolymers of opposite charges, (ii) investigations of biopolymer based microcapsules, i.e. investigations of interactions between bioactive agents and the delivery system, (iii) investigation of conditions for simultaneous encapsulation of biological and chemical agents, (iv) laboratory investigations of optimal microcapsule formulations, (v) in vivo testing of optimal microcapsule formulations on conventionally and hydroponically grown lettuce and tomato.Our efforts will be focused on the investigation of chitosan/alginate microcapsules suitable for simultaneous encapsulation of copper or calcium with Trichoderma viride. The investigations will be done by an interdisciplinary approach on model systems with oppositely charged species based on mixtures containing two biopolymers. Studies of model systems, where the number of variables is greatly reduced, help to explain the intermolecular interactions between oppositely charged biopolymers and bioactive agents, which constitute a highly useful guideline for preparation of novel microcapsule formulations. Various common and modern techniques/methods will be used in investigation. The project, while being fundamental in nature, is of direct practical importance because better understanding of interactions between oppositely charged biopolymers and bioactive agents at the molecular level will serve as a base for production of novel microcapsule formulations for plant protection/nutrition.]]></summary_en></project><project>
<id>3392</id><title_hr><![CDATA[Cijepljenje rajčice ublažava biotički stres izazvan štitastim moljcima ]]></title_hr><title_en><![CDATA[Tomato grafting mitigates biotic stress caused by whiteflies ]]></title_en><user_id>3557</user_id><user_firstLast_name>Katja Žanić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-3365</code><acronim><![CDATA[TomGraf / TomGraf]]></acronim><duration>01.07.2015 - 30.06.2018</duration><status>Završio</status><financ_value>92.308,05 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Institut za jadranske kulture i melioraciju krša]]></institution_hr><institution_en><![CDATA[Institute for Adriatic Crops and Karst Reclamation in Split]]></institution_en><team_members_id>5091, 4176, 3978, 6003, 3954, 4981, 3466, 4400, 1192, 21281, </team_members_id><team_members_names><![CDATA[Gvozden Dumičić, Branimir Urlić, Slavko Perica, Gabriela Vuletin Selak, Ivica Ljubenkov, Dragan Žnidarčič, Maja Jukić Špika, Elda Vitanović, Ivana  Bočina, Marija Mandušić, ]]></team_members_names><keywords_hr><![CDATA[Solanum lycopersicum,  podloge, Bemisia tabaci, Trialeurodes vaporariorum, zaštita bila]]></keywords_hr><keywords_en><![CDATA[Solanum lycopersicum,  rootstocks, Bemisia tabaci, Trialeurodes vaporariorum, pest management]]></keywords_en><summary_hr><![CDATA[Rajčica je važna kultura diljem svijeta, kao i u Hrvatskoj. Spada među najvažnije kulture koje se uzgajaju u zaštićenom prostoru, često u uskom plodoredu. Stoga različiti abiotički i biotički čimbenici stresa ozbiljno ograničavaju ovaj vid uzgoja. Cijepljenje je metoda kojom se izbjegava ili smanjuje gubitak u proizvodnji povrća uzrokovan nepovoljnim uvjetima uzgoja. Tako je cijepljenje, kao metoda za ublažavanje problema izazvanih štetnicima lista rajčice, štitastim moljcima Bemisia tabaci i Trialeurodes vaporariorum, odabrano za glavni cilj projekta TomGraf. Specifični ciljevi su zadani kako bi se utvrdio učinak cijepljenja/podloge na ublažavanje stresa izazvanog s B. tabaci i T. vaporariorum na presadnicama rajčice (ciklus presadnica ljeto/jesen, 2015.), ublažavanje stresa od B. tabaci u hidroponskom nasadu rajčice (ciklus proljeće/ljeto, 2016.) te na ublažavanje stresa od T. vaporariorum u hidroponskom nasadu rajčice (ciklus proljeće/ljeto, 2017.). Istraživanje će se provesti na sorti rajčice Clarabella (necijepljena, cijepljena na vlastiti korijen te cijepljena na četiri komercijalne podloge: Arnold, Beaufort, Emperador i He-Man). Presadnice i hidroponski nasadi rajčice će se infestirati populacijama štitastih moljaca koje održavamo na IJK. Osim glavnog pokusnog zadatka, ocjene gustoće populacije različitih razvojnih stadija štitastih moljaca, učinak cijepljenja istraživat će se i u odnosu na: vegetativni i reproduktivni rast i razvoj rajčice, fiziološke parametre te kvalitetu ploda. Očekujemo odabir podloge/a koja će se moći koristiti kao dio strategije suzbijanja štitastih moljaca, osiguravajući uz to zadovoljavajući učinak na prinos i kvalitetu ploda rajčice.]]></summary_hr><summary_en><![CDATA[Tomato is a crop of high importance worldwide as well as in Croatia. It is among the most grown crops in protected cultivation that is characterised with narrow crop rotation. Consequently, diverse abiotic and biotic stressors seriously limit this type of cultivation. Grafting is a method to avoid or reduce loss in vegetable production caused by adverse growing conditions. Thus, tomato grafting as method to alleviate problems caused by foliar pests; whiteflies Bemisia tabaci and Trialeurodes vaporariorum, has been selected as the main objective of the TomGraf project. The specific objectives have been defined to determine the grafting/rootstock effect on: mitigation B. tabaci and T. vaporariorum stresses on tomato transplants (summer/autumn transplants cycle in 2015), mitigation B. tabaci stress in hydroponically grown tomato (spring/summer cycle in 2016), and mitigation T. vaporariorum stress in hydroponically grown tomato (spring/summer cycle in 2017). The study will be conducted using tomato cv. Clarabella (non-grafted, self-grafted, or grafted onto the commercial rootstocks Arnold, Beaufort, Emperador and He-Man). Tomato transplants and hydroponically grown tomatoes will be infested by whitefly populations maintained at IAC. Besides the main experimental task, the whitefly population densities assessment at different development stages, the effect of grafting on tomato vegetative and reproductive growth and development, physiological parameters and fruit quality will be studied. We expect that selection of rootstock/s can be used as a useful tool in management strategy against whiteflies ensuring the satisfactory effect on yield and fruit quality components.]]></summary_en></project><project>
<id>3393</id><title_hr><![CDATA[Stanica za zamjenu baterija električnih vozila]]></title_hr><title_en><![CDATA[Electric Vehicle Battery Swapping Station]]></title_en><user_id>7162</user_id><user_firstLast_name>Hrvoje Pandžić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-3517</code><acronim><![CDATA[EV BASS]]></acronim><duration>01.10.2015 - 30.09.2018</duration><status>Završio</status><financ_value>99.299,52 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>7001, 4569, 7194, 7348, 6996, 13621, 13656, 7186, 904, 1506, 20536, 20181, </team_members_id><team_members_names><![CDATA[Tomislav Capuder, Marija Furdek, Matija Zidar, Juraj Havelka, Marko Delimar, Ivan Pavić, Iva Širić, Ninoslav Holjevac, Tomislav Dragičević, Danijela Miloš Sprčić, Davor Zoričić, Vedran Bobanac, ]]></team_members_names><keywords_hr><![CDATA[električna vozila, baterije, stanica za izmjenu baterija, poslovni model, optimizacijski model]]></keywords_hr><keywords_en><![CDATA[electric vehicles, batteries, battery swapping station, business model, optimization model]]></keywords_en><summary_hr><![CDATA[Za masovnu upotrebu električnih vozila potrebno je uspostaviti adekvatnu infrastrukturu. Sveprisutan pristup predmetnoj infrastrukturi smanjuje brigu oko dosega električnih vozila i dugih vremena punjenja baterija. Stanice za izmjenu baterija električnih vozila svakako su učinkovito sredstvo za uklanjanje problema dugotrajnog čekanja na punjenje baterija. Te su stanice posrednici između elektroenergetskog sustava i svojih klijenata. Za uspješnu izgradnju i poslovanje ovih stanica potrebno je prvo izraditi poslovni, a potom i operativni model. Na taj će se način osigurati da stanica za izmjenu baterija električnih vozila bude održiva nudeći brzu i pouzdanu uslugu kao alternativu dugotrajnom punjenju baterija.Prvi dio projekta usmjeren je na analizu trenutne situacije u znanstvenoj i stručnoj literaturi, komercijalnim tvrtkama koje se bave električnim vozilima te zakonskim okvirima. Na temelju predmetne analize razvit će se održivi poslovni model stanice za izmjenu baterija električnih vozila. Znanstveno istraživanje će se potom granati u dva smjera. Prvi smjer odnosi se na optimizaciju pogona stanice za izmjenu baterija, što uključuje kreiranje rasporeda pogona za dan unaprijed te u stvarnom vremenu. Drugi smjer odnosi se na upravljanje i komunikaciju unutar same stanice. Naime, potrebno je konstantno poznavati napunjenost svake baterije u stanici te puniti odgovarajuće baterije prema planu punjenja kreiranom od strane optimizacijskog modela.Drugi dio istraživanja bavit će se utjecajem jedne i više stanica za izmjenu baterija električnih vozila na elektroenergetski sustav. Pritom će se zasebno razmatrati gledišta Operatora Distribucijskog Sustava i Operatora Prijenosnog Sustava.Posljednji dio projekta biti će primijenjene naravi. Osmislit ćemo i instalirati stanicu za izmjenu baterija koja će se sastojati od središnjeg računala koje će upravljati stanicom, velikim brojem stogova baterija i popratne upravljačke i komunikacijske opreme. Ovime ćemo ispitati razvijene algoritme u stvarnom okruženju i potvrditi rezultate simulacija.]]></summary_hr><summary_en><![CDATA[For a successful rollout of EVs, it is required to establish an adequate charging infrastructure. The ubiquitous access to such infrastructure would help to mitigate concerns associated with limited EV range and long charging times. Battery Swapping Stations (BSSs) are poised as effective means of eliminating the EVs long waiting times associated with charging the batteries. These stations are mediators between the power system and their customers. In order to successfully deploy this type of stations, business and operating models are required, that will allow it to generate profits while offering a fast and reliable alternative to charging batteries.The first part of the project is focused on analysis of current scientific and commercial state-of-the-art, as well as legislative. Based on this, a viable business model will be developed as a basis of the BSS business case. The research will then diverge in two directions. The first direction is the optimization of the BSS operation, which includes its day-ahead scheduling and real-time operation. The second direction is the control and communication of the BSS. Namely, each battery’s state-of-charge needs to be properly assessed, and its charging pattern needs to correspond to the one set by the optimization model. The second part of the project will assess the impacts that BSS and a group of BSSs have on power systems. Here, points of view of Distribution and Transmission System Operators will be considered.The final stage of the project will be the deployment of a testbed that consists of a central computer, a large number of EV battery stacks, and all the accompanying control and communications infrastructure. This will provide the opportunity to test the developed algorithms in a realistic environment and to verify the results.]]></summary_en></project><project>
<id>3395</id><title_hr><![CDATA[Istraživanje razvoja, diferencijacije i evolucije životinja kroz genomiku bazalnih metazoa ]]></title_hr><title_en><![CDATA[Elucidating animal development, differentiation and evolution through basal metazoan genomics]]></title_en><user_id>1187</user_id><user_firstLast_name>Kristian Vlahoviček</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-6400</code><acronim><![CDATA[BAMGEN]]></acronim><duration>01.10.2015 - 31.12.2019</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>1193, 1221, 1228, 1207, 1225, 1208, 1188, 25324, </team_members_id><team_members_names><![CDATA[Helena Ćetković, Andreja Mikoč, Matija Harcet, Helena Bilandžija, Bruna Pleše, Mirna Imešek, Rosa Karlić, Silvestar Beljan, ]]></team_members_names><keywords_hr><![CDATA[regulacija gena, genomika, transkriptomika, spužve, genomika raka]]></keywords_hr><keywords_en><![CDATA[gene regulation, genomics, transcriptomics, sponges, cancer genomics]]></keywords_en><summary_hr><![CDATA[Projekti velikih razmjera koji uključuju metode -omike priskrbili su veliku količinu znanja o molekularnim mehanizmima u stanicama i tkivima ljudi i modelnih organizama, te pružili mnoštvo informacija o raznolikosti staničnih procesa, poglavito genske regulacije. Ti su projekti ujedno razotkrili neizmjernu kompleksnost životinjske stanice, potencijal za diferencijaciju u stanice različitih tkiva, gubitak kontrole pri nastajanju raka, te time potakli niz dubljih pitanja na različitim područjima znanosti o životu: Kako funkcionira diferencijacija u specifične stanice tkiva? Koliko su mehanizmi genske regulacije očuvani kroz životinjsko carstvo? Odakle potječe kompleksnost procesa diferencijacije? I, konačno, koje je porijeklo višestaničnosti?  Bazalne životinje (Metazoa), ključne su za odgovore na ova pitanja: mi na njih namjeravamo odgovoriti proučavanjem ne-modelnih organizama na samom dnu životinjskog evolucijskog stabla - najjednostavnijim višestaničnim životinjama - spužvama (Porifera). Spužve su najstarije danas živuće životinje koje su se vjerojatno najranije odvojile na razvojnom stablu životinja, te posjeduju neka izvanredna svojstva koja ih čine idealnim modelom za istraživanja regulacije gena uključenih u razvoj: u bliskoj su simbozi s jednostaničnim prokariotima, sadrže mali broj osnovnih tipova stanica, nemaju pravih tkiva, organa ni zametnih listića, a istovremeno posjeduju mnoge gene uključene u rani razvoj i povezane s nastankom raka, kao i totipotentne stanice. Metodama komparativne genomike i transkriptomike, htjeli bismo istražiti procese unutar simbioze, kao i procese razvoja i diferencijacije stanica za koje vjerujemo da su naslijedile sve višestanične životinje.  Pomoću čvrste mreže suradnika, stručnjaka u području biologije Metazoa s iskustvom u  metodama genomike i računalne biologije kompleksnih sustava, te preliminarnim setom zanimljivih rezultata, namjeravamo odgovoriti na prethodno postavljena pitanja i interdisciplinarnim pristupom razjasniti neka od ključnih otvorenih pitanja na području genomike i evolucije čitavog životinjskog carstva.]]></summary_hr><summary_en><![CDATA[Large scale –omics projects have provided valuable knowledge on the molecular mechanisms occurring in cells and tissues of human and other related model organisms, delivering a wealth of information on the diversity of cellular processes, and in particular gene regulation. Yet, these projects have also uncovered the immense complexity of the animal cell, its potential to differentiate into various tissues, or spiral out of control by forming cancer, opening up even more profound questions on diverse fronts of the life sciences: How does tissue-specific cell differentiation work? How conserved are gene regulation mechanisms throughout animal kingdom? Where does complexity of differentiation originate from? And, finally, what is the origin of multicellularity?Basal metazoans hold key answers to these questions: we propose to tackle them by investigating the non-model organisms at the very base of the animal evolutionary tree – the simplest multicellular animals – sponges (Porifera). Sponges, are probably the earliest branching and the oldest extant animals. They hold remarkable properties that make them an excellent subject for studying developmental gene regulation: a handful of major cell types, no true tissues and organs, and no germ layers, but at the same time they are rich in early developmental genes associated to cancer and possessing totipotent cells. With the aid of comparative genomics and transcriptomics, we wish to explore developmental and cell differentiation processes that we believe are ancestral to all multicellular animals.With a strong collaboration network, expert base in metazoan biology, expertise in genomics and computational biology of complex systems, and a preliminary set of interesting results, we propose to answer the above questions through a truly interdisciplinary approach and elucidate some of the crucial open questions in genomics and evolution of the entire animal kingdom. ]]></summary_en></project><project>
<id>3402</id><title_hr><![CDATA[Probiotici i starter kulture – površinski proteini i bakteriocini]]></title_hr><title_en><![CDATA[Probiotics and starter cultures – surface proteins and bacteriocins]]></title_en><user_id>798</user_id><user_firstLast_name>Blaženka Kos</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-7009</code><acronim><![CDATA[PRO-S]]></acronim><duration>01.07.2015 - 30.06.2019</duration><status>Završio</status><financ_value>75.997,68 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Biotehnologija, </scie_field_hr><scie_field_en>Biotechnology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Food Technology and Biotechnology]]></institution_en><team_members_id>796, 797, 800, 1011, 13349, 13182, 18967, 799, 21384, </team_members_id><team_members_names><![CDATA[Jasna Beganović, Andreja Leboš Pavunc, Ksenija Uroić, Ksenija Durgo, LJERKA GREGUREK, Katarina Tonković, Martina Marijanović, Jagoda Šušković, Katarina Butorac, ]]></team_members_names><keywords_hr><![CDATA[probiotici, starter kulture, bakteriocini, površinski proteini, funkcionalnost]]></keywords_hr><keywords_en><![CDATA[probiotics, starter cultures, bacteriocins, surface proteins, functionality]]></keywords_en><summary_hr><![CDATA[Svrha predloženog istraživanja je razvoj nove generacije probiotika i funkcionalnih starter kultura, detaljno okarakteriziranih, sa specifičnim svojstvima kao što je proizvodnja funkcionalnih površinskih S-proteina i bakteriocina. Od ukupno dvjesto različitih autohtonih sojeva bakterija mliječne kiseline (BMK), izoliranih iz tradicionalnih fermentiranih proizvoda u Laboratoriju za tehnologiju antibiotika, enzima, probiotika i starter kultura Prehrambeno-biotehnološkog fakulteta Sveučilišta u Zagrebu, samo pet Lactobacillus sojeva eksprimira sloj S-proteina na površini svojih stanica. Istraživanja će se provoditi s ciljem razjašnjavanja uloge S-proteina u stanicama Lactobacillus sojeva, posebno u važnim probiotičkim svojstvima, kao što su adhezija, kompetitivna ekskluzija patogena i interakcije s imunološkim sustavom domaćina. Istraživanja će također biti usmjerena na proizvodnju bakteriocina autohtonih sojeva BMK, mehanizma njihovog djelovanja i indukciju sinteze bakteriocina. Izolirani autohtoni sojevi BMK bit će dalje ispitivani obzirom na fiziološka i tehnološka svojstva važna pri odabiru funkcionalnih starter kultura. Obzirom da su tradicionalno proizvedeni fermentirani proizvodi bogat izvor novih i potencijalno zanimljivih mikrobnih sojeva poželjnih genetičkih, metabolizamskih i tehnoloških svojstava, okarakterizirani sojevi BMK, proizvedeni kao mikroinkapsulirane i liofilizirane funkcionalne starter kulture će doprinijeti kvaliteti i sigurnosti tradicionalnih fermentacijskih procesa kao i formulaciji inovativnih funkcionalnih proizvoda. Oboje je od velikog značaja za prehrambenu industriju s aspekta proizvodnje hrane s posebno definiranim funkcionalnim (probiotičkim) svojstvima.]]></summary_hr><summary_en><![CDATA[The proposed research is aimed to deliver new generation of probiotics and functional starter cultures, thoughtfully characterised and with specific features such as production of functional surface (S)-layer proteins and bacteriocins. Among more than 200 different autochthonous lactic acid bacteria (LAB) strains isolated from artisanal fermented food products in Laboratory of Antibiotic, Enzyme, Probiotic and Starter Culture Technologies, Faculty of Food Technology, University of Zagreb, only five Lactobacillus strains are found to possess S-layer proteins. This research is intended to clarify the role of S-layer proteins in cells of Lactobacillus species, particularly in important probiotic properties such as adhesion, competitive pathogen exclusion and interactions with host immune system. Researches will also be directed towards bacteriocin production by autochthonous LAB strains, mode of antimicrobial action, as well as the induction of bacteriocin production. Isolated autochthonous LAB strains will be further examined for their physiological and technological properties important during their selection as functional starter cultures. Since artisanal fermented foods are a rich source of new and potentially interesting microbial strains with considerable genetic, metabolic and technological properties, well-defined autochthonous LAB strains, produced as microencapsulated and lyophilised functional starter cultures, will contribute to safety and quality of traditional food fermentation processes and to formulate innovative functional products. Both are of great importance for the food industry in aspect of designing the food with specially defined functional (probiotic) properties.]]></summary_en></project><project>
<id>3404</id><title_hr><![CDATA[Genotip-fenotip korelacija u Alportovom sindromu i nefropatiji tankih glomerularnih bazalnim membrana]]></title_hr><title_en><![CDATA[Genotype-Phenotype Correlation in Alport&#39;s syndrome and Thin Glomerular Basement Membrane Nephropathy ]]></title_en><user_id>3902</user_id><user_firstLast_name>Danica Galešić Ljubanović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-2151</code><acronim><![CDATA[GPofASandTBMN]]></acronim><duration>01.09.2015 - 31.08.2019</duration><status>Završio</status><financ_value>128.734,73 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Kliničke medicinske znanosti, Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Clinical sciences, Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>4633, 441, 13504, 5270, 7036, 5354, 12463, 5028, 4155, 12795, 4839, 12918, 5847, 5960, 4711, 6514, 3838, 4592, 5842, 5871, 19506, 24835, </team_members_id><team_members_names><![CDATA[Petar Šenjug, Tamara Nikuševa Martić, Nina Canki-Klain, Kristina Meljanac Salopek, Marija Perica, Krešimir Galešić, Danica Batinić, Danko Milošević, Marijana Ćorić, Marijan Saraga, Merica Glavina Durdov, Gordana Đorđević, Ivica Horvatić, Matija Crnogorac, Stela Bulimbašić, Anamarija Bauer Šegvić, Mladen Knotek, Rajko Kušec, Ana Livun, Martin Ćuk, Maja Trupković, Matija Horaček, ]]></team_members_names><keywords_hr><![CDATA[Alportov sindrom, nefropatija tankih glomerularnih bazalnih membrana, COL4A3, COL4A4, COL4A5, genotip-fenotip korelacija]]></keywords_hr><keywords_en><![CDATA[Alport’s syndrome, Thin Glomerular Basement Membrane Nephropathy, COL4A3, COL4A4, COL4A5, genotype-phenotype correlation]]></keywords_en><summary_hr><![CDATA[Alportov sindrom (AS) i nefropatija tankih glomerularnih bazalnih membrana (TBMN) su genetski heterogeni, strukturalni poremećaji glomerularne bazalne membrane (GBM). Genetska osnova obaju poremećaja je u mutaciji gena koji kodiraju izoforme kolegena tipa IV.  Glavni simptom u oba poremećaja (AS i TBMN) je hematurija, a glavna razlika je u kliničkom tijeku i progresiji bolesti. Razlikovanje AS i TBMN je važno, ali ponekad komplicirano. Planiramo provesti multidisciplinarno, kolaborativno istraživanje na nacionalnoj razini, u kojem će sudjelovati sedam vodećih hrvatskih nefroloških, pedijatrijsko-nefroloških i nefropatoloških institucija (Klinička bolnica Dubrava,  Klinička bolnica Merkur, Klinički bolnički centri Zagreb, Rijeka i Split, Klinički bolnički centar Sestre Milosrdnice, Zagreb i Klinika za dječje bolesti, Zagreb). Prikupit ćemo kliničke podatke o bubrežnim i izvanbubrežnim simptomima, histološke podatke (uključujući bojenje za lance kolagena tipa IV) i provesti studiju obitelji za AS i TBMN pacijente u Hrvatskoj. U svrhu otkrivanja mutacija gena COL4A5, COL4A4 i COL4A3 koristit ćemo kombinirani pristup - multipleks PCR amplifikaciju, kvantifikaciju amplikona  i  sekvenciranje slijedeće generacije (eng. next generation sequencing). Ove analize će biti provedene u molekularnom laboratoriju Zavoda za patologiju i Centru za translacijska i klinička istraživanja Medicinskog fakulteta Sveučilišta u Zagrebu. Glavni cilj istraživanja je utvrditi prevalenciju AS i TBMN u Hrvatskoj i razjasniti AS i TBMN histološki, genetski i klinički. Naš krajnji cilj je stvoriti Hrvatski  registar AS i TBMN pacijenta s kliničkim, histološkim i genetskim podacima te podacima o praćenju pacijenata. Voditelj projekta je izv.prof.dr.sc. Danica Galešić Ljubanović, a uz nju, na projektu će sudjelovati 20 znanstvenika.]]></summary_hr><summary_en><![CDATA[Alport&#39;s syndrome (AS) and thin basement membrane nephropathy (TBMN) are genetically heterogenic, structural disorders of glomerular basement membrane (GBM). Genetic base of both disorders lies in mutation of genes which encode isoforms of collagen type IV. Major symptom of both disorders (AS and TBMN) is hematuria, and the main difference between them, is clinical course and progression of the disease. The distinction between AS and TBMN is important but may be difficult. Our plan is to conduct multidisciplinary, nationwide, collaborative research in which seven leading Croatian nephrology, pediatric nephrology and nephropathology institutions (Dubrava University Hospital Zagreb, Merkur University Hospital Zagreb, University Hospital Centers Zagreb, Rijeka and Split, University Hospital Center Sisters of Mercy, Zagreb and Children&#39;s Hospital Zagreb) will participate.  We plan to collect clinical data, about both renal and extra-renal symptoms, histological data (including staining for collagen IV chains), as well as, family study data on Croatian AS and TBMN patients.  The combined approach of multiplex PCR amplification, amplicon quantification, and next generation sequencing for COL4A5, COL4A4 and COL4A3 gene mutation screening will be done at molecular laboratory at Department of Pathology and Center for Translational Research, University of Zagreb. School of Medicine. Main goal of our research is to identify prevalence of AS and TBMN in Croatia and to clarify these two entities histologically, genetically and clinically. Our ultimate goal is to create AS and TBMN patients&#39; registry with clinical, histological, genetic and follow up information. Project leader is Associate Professor Danica Galešić Ljubanović, and beside her, on project will work 20 scientists.]]></summary_en></project><project>
<id>3412</id><title_hr><![CDATA[Istraživanje školskog vođenja iz distributivne perspektive u hrvatskim školama]]></title_hr><title_en><![CDATA[Investigating School Leadership From a Distributed Perspective in Croatian Schools ]]></title_en><user_id>4623</user_id><user_firstLast_name>Branko Rafajac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-1825</code><acronim><![CDATA[IScLEAD]]></acronim><duration>01.05.2015 - 30.04.2018</duration><status>Prekinut</status><financ_value>29.705,21 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Pedagogija, </scie_field_hr><scie_field_en>Pedagogy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Filozofski fakultet u Rijeci]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>344, 3032, 13445, 779, 7184, </team_members_id><team_members_names><![CDATA[Vesna Kovač, Nena Rončević, Vjekoslav Robotić, Iva Buchberger, Stjepan  Staničić, ]]></team_members_names><keywords_hr><![CDATA[upravljanje obrazovnim sustavom, distributivno školsko vođenje, učinkovitost škola, jedinice lokalne samouprave, ravnatelji, učitelji, škole]]></keywords_hr><keywords_en><![CDATA[governance of educational system, distributive school leadership, school effectiveness, local educational authorities, school principals, teachers, sc]]></keywords_en><summary_hr><![CDATA[Predloženo istraživanje fokusira se na fenomen školskog vođenja koji se određuje kao jedan od najznačajnijih faktora uspješnosti škola odnosno postignuća učenika, a u širem kontekstu i uspješnosti odnosno održivosti obrazovnih reformi. Glavni cilj istraživanja je identificirati obilježja prakse školskog vođenja u hrvatskim školama s posebnim naglaskom na indikatore individualnog naspram distributivnog vođenja te iznalaženje onih obilježja školskog vođenja koja su povezana s učinkovitosti škola. Glavni cilj istraživanja realizirat će se kroz sljedeće specifične zadatke: 1) Ispitati obilježja školskog vođenja s posebnim naglaskom na ulogu i vrstu participacije i interakcija pojedinih dionika u aktivnostima vođenja (ravnatelja, školskog odbora, učiteljskog/nastavničkog vijeća, stručne službe, učitelja, roditelja, učenika, predstavnika zajednice i lokalne samouprave) i njihove povezanosti s indikatorima školskog uspjeha; 2) Ispitati različita obilježja upravljanja hrvatskim obrazovnim sustavom iz perspektive različitih dionika (komunikacija i suradnja između autoriteta na državnoj razini, razini lokalne samouprave i razini škole; zadovoljstvo načinom funkcioniranja obrazovnog sustava) i njihov efekt na praksu školskog vođenja. Rezultati prijašnjih istraživanja i preliminarni izvještaji povezani s hrvatskim obrazovnim sustavom ukazuju na važnost osnaživanja karakteristika distributivnog školskog vođenja s naglaskom na osnaživanje kapaciteta učitelja kao aktivnih sudionika u procesu donošenja odluka koje se odnose na obrazovanje. ]]></summary_hr><summary_en><![CDATA[The proposed research focuses on the phenomenon of school leadership which is seen as one of the most important success factors of school and student achievement. In the broader context, it is seen as a success i.e. sustainability factor of education reforms. The main aim of this research is to identify the characteristics of the school leadership practice in Croatian schools with the special emphasize on indicators of both solo and distributive leadership and finding those features that are associated with the school and student achievement. The main aim will be elaborated through the following specific tasks: 1) examining the characteristics of school leadership with special emphasis on the role of participation and interaction of individual stakeholders in the activities of leadership (school principals, school boards, school councils, professional services, teachers, parents, students, community representatives and local government) and their association with indicators of school success; 2) examining various features of education system governance from the perspectives of different stakeholders (communication and collaboration between state level, local governments and school level authorities; overall satisfaction with the education system governance) and their effects on the school leadership practice. Results of the previous studies and preliminary review related to Croatian education system point to the importance of strengthening the characteristics of the distributed school leadership with special emphasis on strengthening the capacity of teachers as active participants in making key decisions related to the matters of education.]]></summary_en></project><project>
<id>3414</id><title_hr><![CDATA[Nanokompoziti cinkovog oksida i titanijevog dioksida za fotonaponsku primjenu]]></title_hr><title_en><![CDATA[Zinc Oxide and Titanium Dioxide  Nanocomposites for Photovoltaic Application]]></title_en><user_id>3922</user_id><user_firstLast_name>Andreja Gajović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-9419</code><acronim><![CDATA[ZOTONanoPhotovolt]]></acronim><duration>01.09.2015 - 31.08.2018</duration><status>Završio</status><financ_value>89.162,92 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, Kemija, </scie_field_hr><scie_field_en>Physics, Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>3012, 12522, 12524, 12832, 1271, 5657, 3932, 1338, 12532, </team_members_id><team_members_names><![CDATA[Davor Gracin, Krunoslav Juraić, Daniel Meljanac, Jelena Macan, Nikša Krstulović, Krešimir Salamon, Milivoj Plodinec, Vilko Mandić, Silvije Domazet, ]]></team_members_names><keywords_hr><![CDATA[cinkov oksid, titanijev dioksid, nanokompoziti, fotonaponski uređaji, kemijske metode, magnetronsko rasprašivanje,  pulsna laserska depozicija]]></keywords_hr><keywords_en><![CDATA[zinc oxide, titanium diokside, nanocomposites, photovoltaic solar cells, chemical methods, magnetrons sputtering and pulsed laser deposition]]></keywords_en><summary_hr><![CDATA[Istraživat će se mogućnosti modificiranja svojstava tankih filmova metalnih oksida, prvenstveno ZnO  i TiO2, podešavanjem njihove nano-strukture i aktiviranjem njihove površine. Svojstva će se optimirati primarno za upotrebu u fotonaponskim uređajima no rezultati će biti primjenjivi i za druge opto-električne uređaje, razne vrste senzora, katalizatora itd. Pri tom će se određivati korelacija (nano)strukturnih osobina sa optičkim, vibracijskim i električnim osobinama s jedne strane te ovisnost strukture o parametrima formiranja sa druge. Ovo će omogućiti provjeru teoretskih predviđanja vezanih za defekte i nisko-dimenzionalne strukture i modeliranje rasta tankih filmova. Nastojat će se realizirati nano-strukture koje su izdužene u smjeru okomitom na površinu,  sastoje se od jedne vrste oksida a dekorirane su drugom vrstom oksida. Od njih se očekuje značajno povećanje efikasnosti fotonaponskih ćelija. Tehnike priprave će biti: (i) kemijske metode, (ii) vakuumske depozicije pomoću magnetronskog rasprašivanja i pulsne laserske depozicije (PLD). Kemijske metode (uključujući sol-gel tehnike i hidrotermalnu sintezu) ostavljaju velike mogućnosti u formiranju raznih nano-struktura (npr. nano-kristali, nano-žice, nano-plohe, nano-cjevčice) i olakšavaju veću fleksibilnost pri optimizaciji priprave te bolju statistiku u određivanju povezanosti  nano-strukture sa svojstvima. S druge strane, fotonaponske solarne ćelije podrazumijevaju formiranje slojeva na velikim površinama pa razne tehnike formiranja kao što su magnetronska depozicija i PLD imaju evidentnu prednost. Također, obrada površine plazmom je prirodno povezana sa magnetronskom depozicijom i PLD. Zbog toga će se posebna pažnja posvetiti ovim dvjema tehnikama. Optimalne strukturna svojstva, koji će se eksperimentalno potvrditi kombinacijom kemijskih metoda, će se nastojati postići magnetronskom depozicijom i PLD.Projekt će dijelom bit posvećen edukaciji doktorskih i postdoktorskiih studenta. ]]></summary_hr><summary_en><![CDATA[The possibility of modification the properties of thin film metal oxides , primary ZnO and TiO2,  by adjusting nano-structure and by activation of surfaces will be explored. The properties will be primary adjusted for use in photovoltaic solar cells while results will be applicable for other opto-electronic devices, sensors, catalysts etc.Project activities assume study of correlation between details of (nano)structural properties with optical, vibrational and electrical from one side and correlation between structure and parameters of deposition from other side. This will enable test of theoretical predictions related to defects and low dimensional structures and models of thin film growth as well. The main challenge is nano-structures elongated in the direction perpendicular to the surface, based on one type of oxide while decorated with other type of oxide. By using these structures significant increase the efficiency of photovoltaic cells is expected.Two basic preparation techniques will be used: (i) chemical methods and (ii) vacuum deposition by magnetrons sputtering and pulsed laser deposition (PLD). The chemical methods (including sol-gel technique and hydrothermal syntheses) enable relatively simple formation of various nano-structures (e. g. nano-crystals, nano-wires, nano-sheets, nano-tubes) providing larger flexibility for optimization of the preparation, and better statistics for understanding the correlation between nano-structure and properties. On the other hand, photovoltaic solar cells assume deposition of the films on large areas and for this purpose magnetron sputtering and PLD seem more suitable. Furthermore, the surface modification by plasma treatment looks appealing in combination with vacuum deposition techniques or PLD. That is why the optimal structural properties found by chemical methods will be goal to be obtained by magnetron sputtering or PLD techniques. Project will be partially devoted to education of the PhD and Postdoc. students.]]></summary_en></project><project>
<id>3415</id><title_hr><![CDATA[Iznad Nyquistove granice]]></title_hr><title_en><![CDATA[Beyond the Nyquist limit]]></title_en><user_id>6982</user_id><user_firstLast_name>Damir Seršić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-2625</code><acronim><![CDATA[BeyondLimit]]></acronim><duration>01.10.2015 - 30.09.2019</duration><status>Završio</status><financ_value>129.802,91 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, Računarstvo, </scie_field_hr><scie_field_en>Electrical engineering, Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>6945, 6991, 6592, 21316, 22636, 25370, 17809, </team_members_id><team_members_names><![CDATA[Mladen Vučić, Davor Petrinović, Ana Sović, Maja Jurišić Bellotti, Ivan Ralašić, Nikola Vrebčević, Matea Đonlić, ]]></team_members_names><keywords_hr><![CDATA[pod-Nyquistovsko uzorkovanje, sažimajuće očitavanje, kauzalni splajnovi, rijetke reprezentacije, adaptivni valići, napredni dizajn sustava]]></keywords_hr><keywords_en><![CDATA[sub-Nyquist sampling, compressive sensing, causal splines, sparse representations, adaptive wavelets, advanced system design]]></keywords_en><summary_hr><![CDATA[Moderne informacijske i komunikacijske tehnologije suočene su s nizom izazova. Među njima izdvojili smo dva važna: ogromnu količinu podataka koja dolazi iz realnog svijeta putem senzora, kao i snagu računala potrebnu za njihovu obradu. U ovom projektnom prijedlogu smo se usmjerili na oba navedena izazova, kao i na napredne primjene ponuđenih rješenja.Desetljećima, Nyquistova granica postavlja doseg rada digitalnih elektroničkih sustava koji djeluju u analognom svijetu. Korištenjem našeg prethodnog istraživanja u području kauzalnih splajnova, adaptivnih valića, rijetkih reprezentacija te naprednog dizajna sustava, razvit ćemo originalni sustav koji radi iznad Nyquistove granice. Pod-Nyquistovsko uzorkovanje u uniji analognih potprostora te sažimajuće očitavanje su područja istraživanja korištena za postizanje ovog cilja. Obje tehnike rezultiraju aplikacijama koje idu preko poznatih granica: rezultiraju u novim tehnikama prikupljanja i obrade slika, naprednim radarskim i sonarskim uređajima, širokopojasnom programski definiranom radiju, kao i naprednim sustavima za obradu govornih i audio signala. Oslanjaju se na rijetke reprezentacije signala, sofisticiranu rekonstrukciju i algoritme za obradu signala, kao i na inteligentne implementacije koje kombiniraju analogne i digitalne podsustave.Istraživači okupljeni u ovom projektnom timu imaju iskustvo u modeliranju rijetkim signalima, dizajnu naprednih analognih i digitalnih sustava, a razvili su i različite aplikacije u obradi slika, audio i govornih signala. Razvit ćemo originalan sustav iznad Nyquistove granice zasnovan na našim kauzalnim splajnovima. Koristit ćemo naše adaptivne sustave i brze L1 minimizacijske algoritme radi postizanja rijetkih reprezentacija potrebnih u sažimajućem očitavanju. Rezultati će se koristiti u dizajnu novog pod-Nyquistovog sustava, čija će se realizacija oslanjati na naš napredni dizajn. Razvit ćemo aplikacije u obradi 3D signala, slika te obradi audio i govornih signala.]]></summary_hr><summary_en><![CDATA[Modern information and communication technologies face various challenges. We identified two of them as important: huge amount of data delivered from the real world via sensing devices, and computing power required for its processing. Both challenges are targeted in our project proposal, as well as some advanced applications of the proposed solutions.For decades, Nyquist limit sets the achievable work range of digital electronic systems operating in an analogue world. Using our previous research and expertise in causal splines, adaptive wavelets, sparse representations, and advanced system design, we will develop an original system that works beyond the Nyquist limit. Sub-Nyquist sampling in a union of analogue subspaces and compressive sensing are research topics used to achieve this goal. Both approaches result in applications that go beyond the known limits: they result in novel imaging techniques, advanced radar and sonar devices, wide-band software defined radios, as well as in advanced speech and audio processing systems. They rely on sparse representation of signals, sophisticated reconstruction and signal processing algorithms, as well as on intelligent hardware implementations that mix analogue and digital subsystems. The researchers gathered in this project team have research experience in causal splines, adaptive wavelets and sparse signal modeling, as well as in design of advanced analogue and digital systems. They have developed various applications in image, audio and speech signal processing. We will develop an original beyond Nyquist system based on our causal splines. We will use our adaptive systems and fast L1 minimization algorithms to achieve sparse representations needed in compressive sensing. The results will be used in design of novel sub-Nyquist systems, whose realization will rely on our advanced system design. We will develop its applications in 3D, image, audio and speech signal processing.]]></summary_en></project><project>
<id>3416</id><title_hr><![CDATA[Brendiranje Turističke Destinacije: Analiza Uspješnosti Brenda u Kontekstu Procesa Brendiranja Destinacije ]]></title_hr><title_en><![CDATA[The Branding of Tourism Destinations: Looking at Brand Performance in the Context of the Destination Branding Process ]]></title_en><user_id>1363</user_id><user_firstLast_name>Josip Mikulić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2014-09</proposal_call><code>UIP-2014-09-7005</code><acronim><![CDATA[DESTBRAND]]></acronim><duration>01.07.2015 - 30.06.2019</duration><status>Prekinut</status><financ_value>35.235,89 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, </scie_field_hr><scie_field_en>Economy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Ekonomski fakultet u Zagrebu]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Economics and Business]]></institution_en><team_members_id>217, 5771, 878, 6272, 6616, 13555, </team_members_id><team_members_names><![CDATA[Damir KREŠIĆ, Petra BARIŠIĆ, Maja ŠERIĆ, Darko PREBEŽAC, Katarina MILIČEVIĆ, IRENE GIL-SAURA, ]]></team_members_names><keywords_hr><![CDATA[turizam, destinacija, marketinški menadžment, vrijednost marke/brenda, proces kreiranja marke/brendiranja, model ]]></keywords_hr><keywords_en><![CDATA[tourism, destination, marketing management, brand equity, brand buidling process, model]]></keywords_en><summary_hr><![CDATA[Suvremena istraživanja iz područja turizma naglašavaju potrebu kreiranja marke turističke destinacije (u nastavku će se rabiti izraz: brendiranje) i stvaranje vrijednosti destinacijske marke (u nastavku će se rabiti izraz: brend) kao preduvjet održive tržišne pozicije u vremenima sve veće tržišne saturacije i konkurencije. Istodobno, istraživači naglašavaju kako se ovdje radi o izuzetno složenim procesima. Međutim, do sada je provedeno tek nekoliko empirijskih istraživanja koja su se bavila konceptom brenda turističke destinacije, a u svojem pristupu postojeća istraživanja su usko fokusirana, te su ograničena samo na pojedine aspekte brendiranja i vrijednosti brenda. Cjelovita i sustavna istraživanja na temu vrijednosti destinacijskog brenda, koja uključuju njegove determinante i učinke, gotovo da ne postoje. Iako je nekoliko istraživača iz područja turizma predložilo modele za mjerenje vrijednosti brenda, većina je tih studija ograničeno na hotelijerstvo, dok je problematika stvaranja vrijednosti brenda turističke destinacije do sada bila relativno zanemarena. Sukladno tome, jedan je od glavnih ciljeva ovog projekta je razvoj cjelovitog modela vrijednosti destinacijskog brenda koji uključuje njegove relevantne determinante i učinke. Nadalje, iako postoji cijeli niz istraživanja koja se intenzivno bave analizom pojedinih determinanti vrijednosti brenda destinacije, kao što su npr. svjesnost o brendu, imidž brenda, kvaliteta/atraktivnost destinacije, ili lojalnost mjestu/destinaciji, tek je manji broj istraživanja pokušao uspostaviti vezu između prakse brendiranja koju provode organizacije za destinacijski menadžment, s jedne strane, i učinaka procesa brendiranja mjerenih razinom performansi brenda, s druge strane. Pojašnjenje  ove sprege pomoglo bi uspostavljanju smjernica najbolje, ili u najmanju ruku bolje prakse s područja brendiranja turističke destinacije. ]]></summary_hr><summary_en><![CDATA[Several researchers highlight the importance of branding tourism destinations and building destination brand equity as a prerequisite for achieving a sustainable market position on an increasingly saturated and competitive market. Meanwhile, researchers also acknowledge the complexity of these processes. Empirical research on the destination brand concept has, however, so far been rather scarce and fragmented. Moreover, comprehensive and systematical research of destination brand equity, encompassing the individual determinants-antecedents and outcomes-consequences, are almost completely lacking. Although a number of researchers have proposed models for measuring brand equity in tourism, these contributions were mainly limited to the hotel industry, while brand-equity building in the context of destinations is rather neglected. Accordingly, developing a comprehensive model of destination brand equity, which integrates both important antecedents and consequences, is one important research gap this project aims to address and fill. Moreover, while several antecedents of destination brand equity have been studied in particular detail, like e.g. brand awareness, brand image, destination quality/attractiveness, or most recently place attachment, very few studies have, in fact, tried to establish a connection between branding practices of destination management organizations and the aimed, as well as the truly achieved, outcomes of these practices. Accordingly, as the first of its kind, the proposed project aims to shed light on the relationship between the destination branding process, on the one hand, and the outcome of this process in terms of brand performance levels, on the other hand. Insight into this relationship should help to establish best or, at least, better practice guidelines for the branding of tourism destinations.]]></summary_en></project><project>
<id>3421</id><title_hr><![CDATA[Izvori, pomagala i studije za hrvatsku povijest od srednjeg vijeka do kraja dugog 19. stoljeća]]></title_hr><title_en><![CDATA[Sources, Manuals and Studies for Croatian History from the Middle Ages to the End of the Long Nineteenth Century]]></title_en><user_id>3017</user_id><user_firstLast_name>Damir Karbić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-6547</code><acronim><![CDATA[IZVORISRV19ST]]></acronim><duration>01.06.2015 - 31.05.2019</duration><status>Završio</status><financ_value>67.237,37 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Povijest, </scie_field_hr><scie_field_en>History, </scie_field_en><institution_hr><![CDATA[Hrvatska akademija znanosti i umjetnosti]]></institution_hr><institution_en><![CDATA[Croatian Academy of Sciences and Arts]]></institution_en><team_members_id>3006, 2525, 1535, 4085, 4071, 3036, 1534, 4892, 382, 418, 5605, 6151, 6145, 13552, 13178, 5315, 5727, 6488, 4169, 5546, 4469, </team_members_id><team_members_names><![CDATA[Zoran Ladić, Tihana Luetić, Branka Grbavac, Sabine Florence Fabijanec, Suzana Miljan, Goran Budeč, Iva Kurelac, Vesna Tudjina, Lovorka Čoralić, Filip Novosel, Ivan Jurković, Mirjana Matijević Sokol, Tomislav Galović, Krisztina Arany, Judit  Gal, Éva Bátoriné Halász, Zrinka Novak, Mirko Sardelić, Robert Kurelić, Christopher Nicholson, Martyn Rady, ]]></team_members_names><keywords_hr><![CDATA[povijesni izvori, pomoćne povijesne znanosti, društvena povijest, gospodarska povijest, normativni pravni izvori]]></keywords_hr><keywords_en><![CDATA[historical sources, auxiliary disciplines of history, social history, economic history, legal normative sources]]></keywords_en><summary_hr><![CDATA[Opći cilj projekta je priupljanje, znanstvena analiza i izdavanje izvora za društvenu, kulturnu i gospodarsku povijest Hrvatske od srednjeg vijeka do kraja dugog 19. st., izrada priručnika potrebnih za njihovo istraživanje, te, na njihovom temelju, pisanje studija (članaka i monografija) koji se tiču, u prvom redu, društvene i gospodarske povijesti Hrvatske. To je jedan od projekata koji su se razvili iz istraživanja koja se već tradicionalno provode u istraživačkom okviru Odsjeka za povijesne znanosti Zavoda za povijesne i društvene znanosti Hrvatske akademije znanosti i umjetnosti. Prvenstveni cilj rada na projektu je priprema i objavljivanje kritičkih izdanja izvora potrebnih drugim istraživačima za njihova daljnja istraživanja. Cilj mu je dopunjavanje i kompletiranje starijih izdanja izvora novim arhivskim istraživanjima i nastavljanje već uspostavljenih zbirki, ali i uspostavljanje nekih novih i započinjanje njihovog publiciranja. Pažnja će biti posvećena i proučavanju starije (u prvom redu one ranonovovjekovne) historiografije ao izvora za društvenu, političku, gospodarsku i kulturnu povijest. Istraživački rad na projektu rezultirati će novim izdanjima povijesnih izvora kvalitetno i kritički pripremljenim i njima opskrbiti hrvatsku i međunarodnu znanstvenu javnost, ako i s nužno potrebnim priručnicima. Metodologija korištena tijekom rada na tim zadacima biti će ona uobičajena za slična istraživanja (utemeljena na općim načelima egdotike i drugih pomoćnih povijesnih disciplina). Uključivanjem u rad mlađih istraživača i kroz suradnju s drugim ustanovama, pomoći će se obrazovanje i trening mlađih znanstvenika. Rezultati rada na projektu biti će predstavljeni znanstvenoj javnosti i putem znanstvenih studija objavljenih u Akademijinim izdanjima i izvan njih u Hrvatskoj i inozemstvu, kao i sudjelovanjem u i organiziranjem važnih znanstvenih skupova i drugih znanstvenih događanja u zemlji i inozemstvu.]]></summary_hr><summary_en><![CDATA[General aim of the project is collecting, scholarly analysing and editing of sources for social and economic history of Croatia from the Middle Ages to the end of the long 19th century, creating manuals needed for research of them, and, based on their research, writing studies (articles, monographs) regarding in the first place social and economic history of Croatia. It is one of the projects evolved from the research already traditionally conducted within the research framework of the Division of Historical Studies of the Institute of Historical and Social Studies of CASA. Primary goal of the work on the project is preparation and publishing of critical editions of sources needed for other researchers for their further research. It is aimed on adding and completing older editions of sources by new archival research and continuation of already established collections and on establishing some new ones and starting their publishing. Attention will be dedicated also to the study of former historiography as a source for social, political, economic and cultural history. Research on the project will result in new editions of sources providing Croatian and international scholarly audience historical sources prepared qualitatively and with criticism, as well as with desperately needed manuals. Methodology used during the work on these tasks will be that usual for such research (based on the general principles of the egdotics and other auxiliary disciplines). By including in work young researchers and through the cooperation with other institutions, it will also help to the education and training of younger scholars. The results of the work on the project will be presented to scholarly public also as studies published within the Academy editions and outside of them in Croatia and abroad, and by participation and organisation of important scholarly conferences and other events in the country and abroad.]]></summary_en></project><project>
<id>3427</id><title_hr><![CDATA[Eksperimentalno istraživanje, optimizacija i karakterizacija rada klipnog motora uz &#39;&#39;dual-fuel&#39;&#39; izgaranje]]></title_hr><title_en><![CDATA[Experimental research, optimization and characterization of piston engine operation with dual-fuel combustion]]></title_en><user_id>11160</user_id><user_firstLast_name>Darko Kozarac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-1089</code><acronim><![CDATA[DUFCOROC]]></acronim><duration>01.09.2015 - 31.08.2019</duration><status>Završio</status><financ_value>123.494,59 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, Tehnologija prometa i transport, </scie_field_hr><scie_field_en>Mechnical engineering, Transport technology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>13468, 13461, 13464, 13457, 13456, 17793, </team_members_id><team_members_names><![CDATA[Momir Sjerić, Petar Ilinčić, Rudolf Tomić, Mladen Božić, Ante Vučetić, Mario Sremec, ]]></team_members_names><keywords_hr><![CDATA[dual-fuel, prirodni plin, diesel, izgaranje, optimizacija, značajke rada, emisije]]></keywords_hr><keywords_en><![CDATA[dual-fuel, natural gas, diesel, combustion, optimization, performance, emissions]]></keywords_en><summary_hr><![CDATA[Svrha istraživanja je istražiti mogućnosti korištenja prirodnog plina (CNG) u motorima s unutarnjim izgaranjem s naglaskom na „dual-fuel“ motore. „Dual-fuel“ motori su modificirani motori s kompresijskim paljenjem (Diesel motori) kod kojih se CNG koristi kao glavno gorivo, a njegovo izgaranje se inicira ubrizgavanjem male količine dizelskog goriva. „Dual-fuel“ izgaranje ima karakteristike izgaranja motora s kompresijskim paljenjem ali i onih sa stranim paljenjem. Korištenje CNG-a kao djelomični dodatak dizelskom gorivu predložen je zbog čišćeg izgaranja, široke dostupnosti te potencijala za smanjenje globalne (CO2) i lokalne (NOx, čađa) emisije ispušnih plinova iz klipnih motora.Glavni cilj istraživanja je istražiti ostvarive performanse i emisije motora s unutarnjim izgaranjem koji radi s „dual-fuel“ izgaranjem. Za određivanje granica rada motora biti će provedena optimizacija određenih radnih parametara, a sve s ciljem iskorištenja svih teoretskih prednosti „dual-fuel“ izgaranja, u cijelom radnom području motora. Budući da je inicijalni pregled literature pokazao da motori koji rade s „dual-fuel“ izgaranjem imaju određenih problema pri malim i velikim opterećenjima, posebna pozornost bit će posvećena istraživanju mogućem upravljanju rada u tim radnim područjima. Stoga će biti ispitan i HCCI (Homogeneous Charge Compression Ignition) način izgaranja s dva goriva (CNG i dizelsko gorivo) uz povrat hladnih i toplih ispušnih plinova.Kako bi se ostvarili ciljevi istraživanja potrebno je napraviti specifične modifikacije postojećeg eksperimentalnog postava. Nakon toga, provesti će se ciljani eksperimenti te će radni parametri motora biti optimirani u skladu s kriterijima za postizanje najveće korisnosti uz zadovoljavanje kriterija postavljenih na emisiju ispušnih plinova. Stvarne značajke rada realnog motora biti će dobivene pomoću simulacijskog modela koji će imati sve potrebne elemente, a koristiti će eksperimentalne podatke za opis procesa izgaranja.]]></summary_hr><summary_en><![CDATA[The purpose of the research is to investigate the possibilities of utilizing natural gas (CNG) in the internal combustion engine with the focus on dual-fuel engines. Dual-fuel engines are modified compression-ignition (Diesel) engines, where CNG is used as the main fuel which is ignited by a small amount of Diesel fuel. Dual-fuel combustion shares characteristics with both compression-ignition and spark-ignition combustion. The use of CNG as a partial supplement for Diesel fuel has been suggested due to the cleaner nature of combustion, its worldwide availability and its potential to reduce both global (CO2) and local (NOx, soot) exhaust gas emissions from piston engines.The main objective of the research is to investigate the possible performance and emissions of an IC engine running under dual-fuel combustion mode. To obtain the boundaries of engine operation the optimization of specific operating parameters will be made in order to take the full advantage of all theoretical benefits of dual-fuel combustion, in the entire engine operating range. Since the initial literature review showed that dual-fuel engines have certain problems at low and high operating loads, special emphasis will be put in research of operating options in these regimes. Therefore, HCCI (Homogeneous Charge Compression Ignition) with two fuels (CNG and Diesel) and cold and warm EGR operation will be examined.In order to reach the research objectives, it is necessary to make appropriate modifications on the existing experimental setup. Following the modifications, appropriate experiments will be performed, after which the engine parameters will be optimized with the criteria to maximize the efficiency, while satisfying appropriate exhaust gas emissions. Given the results will be obtained from an experimental setup, the real engine performance will be evaluated by a simulation model that features all necessary engine components but uses the combustion performance data from experimental engine.]]></summary_en></project><project>
<id>3431</id><title_hr><![CDATA[Velebit od vrha do dna - multidisciplinarno istraživanje seizmoloških značajki i tektonike područja Velebita]]></title_hr><title_en><![CDATA[Velebit top to bottom – multidisciplinary research linking seismological data and tectonics in the Mt. Velebit region]]></title_en><user_id>37</user_id><user_firstLast_name>Marijan Herak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-9666</code><acronim><![CDATA[VELEBIT]]></acronim><duration>01.06.2015 - 31.05.2019</duration><status>Završio</status><financ_value>132.191,92 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Geofizika, </scie_field_hr><scie_field_en>Geophysics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>7702, 39, 12953, 40, 199, 12406, 208, 210, 282, 281, 12913, 12922, 12912, </team_members_id><team_members_names><![CDATA[Bruno Tomljenović, Davorka Herak, Igor Vlahović, Snježana Markušić, Josip Stipčević, Bojan  Matoš, Iva Dasović, Ivo Allegretti, Ivica Sović, Ines Ivančić, Snježan Prevolnik, Krešimir Kuk, Tomislav Fiket, ]]></team_members_names><keywords_hr><![CDATA[seizmologija, seizmičnost, seizmotektonika, potres, funkcije prijemnika, tomografija, atenuacija, anizotropija, potresna opasnost]]></keywords_hr><keywords_en><![CDATA[seismology, seismicity, seismotectonics, earthquake, receiver functions, tomography, attenuation, anisotropy, earthquake hazard]]></keywords_en><summary_hr><![CDATA[Seizmičnost šireg područje Velebita znatno je manja one u susjednim regijama prema SZ i JI. Instrumentalno zabilježeni potresi su plitki i slabi do umjereni. Nisku razinu seizmičke aktivnosti ovoga područja nije moguće uvjerljivo objasniti niti jednim od predloženih tektonskih modela cirkum-jadranske regije, prema kojima ova zona niske seizmičnosti ne bi trebala postojati! Predlažemo provesti multidisciplinarno seizmološko i tektonsko istraživanje, koje uključuje i postavljanje guste mreže seizmografa čiji bi podaci trebali omogućiti lociranje žarišta te račun mehanizama i za slabe potrese, analizu funkcija prijemnika, tomografiju pomoću mikroseizmičkog nemira, te procjenu atenuacije i anizotropije. Zajedno s tektonskim istraživanjima koja će omogućiti izradu geoloških profila te rekonstrukciju tektonske evolucije i polja paleo-naprezanja, nadamo se približiti odgovorima na sljedeća pitanja: - Je li niska seizmičnost u okolici Velebita samo privremena, ili je to značajka povezana sa seizmotektonikom toga prostora? Je li seizmički hazard tamo potcijenjen? - Postoji li uopće reversni Velebitski rasjed koji se smatra glavnom seizmogenom strukturom u ovome dijelu vanjskih Dinarida? Ako da, gdje je, kakva su mu geometrijska i kinematička svojstva i je li još uvijek aktivan? - Koji su rasjedi u području Velebita seizmogeni? - Možemo li povezati prividni manjak seizmičnosti s dubokim strukturama, tj. s nepostojanjem subduciranog dijela Jadranske mikroploče ispod ovog dijela Dinarida, ili je to posljedica drugačije kinematičke prošlosti? - Kakva je uloga litosfernih procesa u širem području Velebita u sveukupnom razvoju Dinarida i kako se oni povezani sa sadašnjim tektonskim procesima? - Možemo li poboljšati znanje o topografiji Mohorovičićevog diskontinuiteta? - Što prostorna razdioba grupnih brzina površinskih valova govori o vertikalnoj razdiobi brzina prostornih valova? - Razlikuju li se atenuacijska i anizotropna svojstva području Velebita i u susjednim područjima?]]></summary_hr><summary_en><![CDATA[The area of proposed multidisciplinary research covers a part of the External Dinarides in Croatia centred at Mt. Velebit. This area exhibits conspicuously lower seismicity than the neighbouring regions to the NW and to the SE. Recorded earthquakes are shallow and weak. The apparent low level of seismic activity here is not readily explainable by the proposed tectonic models of the circum-Adriatic area, according to which this quiescent region is not expected to exist at all! We propose to undertake seismological and tectonic study involving installation of a dense seismograph network whose data should enable accurate location and FPS computation for weak events, receiver function analyses, ambient noise tomography, investigation of attenuation and anisotropy, etc. Together with tectonic survey which will enable construction of geological cross-sections and reconstruction of tectonic evolution and  paleo-stress fields we hope to get closer to answering the following questions: - Is the low-seismicity gap that we observe in the Mt. Velebit region a seismic quiescence, or is it a feature related to seismotectonics? Is the seismic hazard underestimated? - Does the Velebit thrust, which is considered as the major seismogenic fault, exist or not? If so, where is it located, what are its geometry and kinematics and is it still active and potential seismogenic source? - Which are seismogenic fault sources in the Mt. Velebit area?- Can we link apparent seismic gap with the deep structures i.e. the missing subduction slab under this area, or is it related to a different kinematic history of this area?- What roles do the lithospheric processes under the Velebit area play in the development of the Dinarides?- Can we improve our knowledge on the Moho-topography?- What does the surface-wave group velocity spatial distribution tell us about the velocity structure?- Do the attenuation or anisotropy properties in the Mt. Velebit region differ from those in the neighbouring areas?]]></summary_en></project><project>
<id>3434</id><title_hr><![CDATA[Divlja loza (Vitis vinifera subsp. sylvestris): vrijedan izvor gena za oplemenjivanje vinove loze]]></title_hr><title_en><![CDATA[The wild grape (Vitis vinifera subsp. sylvestris): a valuable source of genes for grapevine breeding]]></title_en><user_id>1507</user_id><user_firstLast_name>Goran Zdunić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2014-09</proposal_call><code>UIP-2014-09-9737</code><acronim><![CDATA[WI.GRA.GENE]]></acronim><duration>01.07.2015 - 30.06.2018</duration><status>Završio</status><financ_value>79.023,16 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, Šumarstvo, Biotehnologija, Prehrambena tehnologija, </scie_field_hr><scie_field_en>Agriculture, Forestry, Biotechnology, Food technology, </scie_field_en><institution_hr><![CDATA[Institut za jadranske kulture i melioraciju krša]]></institution_hr><institution_en><![CDATA[Institute for Adriatic Crops and Karst Reclamation in Split]]></institution_en><team_members_id>2795, 2826, 2976, 1182, 3132, 3236, 3501, 4236, 13761, 21312, </team_members_id><team_members_names><![CDATA[Ana Mucalo, Tomislav Radić, Maja Žulj Mihaljević, Irena Budić-Leto, Edi Maletić, Katarina Hančević, Lukrecija Butorac, Marijo Leko, Erika  Maul, Katarina Lukšić, ]]></team_members_names><keywords_hr><![CDATA[divlja loza, SSR markeri, domestikacija, ampelografija, genetika]]></keywords_hr><keywords_en><![CDATA[wild grape, SSR markers, domestication, amperlography, genetic]]></keywords_en><summary_hr><![CDATA[Divlja loza (Vitis vinifera subsp. sylvestris Gmel.) predak kultivirane vinove loze nikad nije detaljno istražena u Hrvatskoj. Prirodno stanište ove ugrožene europske biljke (prema IUCN Crvenoj listi ugroženih biljnih vrsta) je relativno netaknuta šuma u neposrednoj blizini vode. Genetska sličnost divlje i kultivirane loze je vrlo visoka (uključujući seksualnu kompatibilnost) iako divlja loza nije pretrpjela strog selekcijski proces domestifikacije. Dakle, tu postoje jedinstvene osobine i aleli još uvijek prisutni u genomu divlje loze, koje treba istražiti i koristiti u suvremenom cijepljenju vinove loze. Glavni ciljevi ovog projekta su i) procijeniti genetsku i fenotipsku raznolikost divlje loze u istraživanoj regiji i njihovu povezanost sa autohtonim sortama vinove loze u uzgoju, ii) sačuvati genetsku raznolikost, iii) istražiti neke morfološke i genetske karakteristike divlje loze koje su od posebnog interesa u programima cijepljenja i mogu pomoći u transferu određenih korisnih gena koji nisu bili cijenjeni tijekom domestifikacije i selekcije od strane ljudi jedinstven je doprinos ovog područja istraživanja. Ovaj projekt će omogučiti osnivanje genetskog laboratorija za DNA karakterizaciju vinove loze na IJK, okupljanje tima znanstvenika usmjerenih na divlju lozu omogućava multidisciplinarni uvid i povečanje vidljivosti i suradnje hrvatske istraživačke grupe sa međunarodnom znanstvenom zajednicom za lozne genetske resurse i istraživačku suradnju.]]></summary_hr><summary_en><![CDATA[The wild grapevine (Vitis vinifera subsp. sylvestris Gmel.) is an ancestor of cultivated grapevine and has never been explored in detail in Croatia. Natural native habitats for this endangered European plant (according to the IUCN Red list of threatened plant species) are relatively untouched forest with significant nearby water. The genetic similarity between wild and cultivated grapes is very high (including sexual compatibility) although the wild grape has not passed through the strict selection process of domestication. Thus, there are possible unique traits and alleles still present in the wild grape genome, which should be explored and used in modern grapevine breeding. The main objectives of this project are to i) assess the overall genetic and phenotypic diversity of wild grape in this region and their relatedness to local cultivated grapevine, ii) preserve the genetic diversity, iii) investigate some morphological and genetic characteristics of wild grape that are of special interest to breeding programs to aid transfer of certain beneficial genes that were not favoured during domestication and human selection bringing unique contribution to this research field. This project will enable the installation of a genetic laboratory for grapevine DNA characterization at the IAC, gather a team of scientists focused on wild grape to deliver multidisciplinary insight, and increase the visibility and collaboration of this Croatian research group with the international scientific community for grape genetic resources, and research collaboration.]]></summary_en></project><project>
<id>3436</id><title_hr><![CDATA[Houses, Roads & Traders of the Early European Civilization]]></title_hr><title_en><![CDATA[Houses, Roads & Traders of the Early European Civilization]]></title_en><user_id>8198</user_id><user_firstLast_name>Marcel Burić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2014-09</proposal_call><code>UIP-2014-09-7131</code><acronim><![CDATA[HRTEC]]></acronim><duration>20.06.2015 - 19.06.2018</duration><status>Prekinut</status><financ_value>66.559,69 eur</financ_value><scie_area_hr>Humanističke znanosti, Prirodne znanosti, Biomedicina i zdravstvo, </scie_area_hr><scie_area_en>Humanities, Natural sciences, Biomedicine and health sciences, </scie_area_en><scie_field_hr>Arheologija, Fizika, Kemija, Biologija, Sociologija, </scie_field_hr><scie_field_en>Archeology, Physics, Chemistry, Biology, Sociology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>13009, 12907, 13548, 11234, 13027, 12960, </team_members_id><team_members_names><![CDATA[David Orton, Anne de Vareilles Sommieres, Tihomila Težak-Gregl, Jelena Lapić, Mateja Hulina, Zdravka Hincak, ]]></team_members_names><keywords_hr><![CDATA[Kasni neolitik, istočna Hrvatska, Bapska, Bogdanovci, višeslojno naselje, socijalna struktura, interdisciplinarne analize]]></keywords_hr><keywords_en><![CDATA[The Late Neolithic Period, Eastern Croatia, Bapska, Bogdanovci, tell, Social structure, Interdisciplinary approach]]></keywords_en><summary_hr><![CDATA[Projekt Houses, Roads & Traders of the Early European Civilization (HRTEC) dizajniran je kako bi se pronašli odgovori na još uvijek neodgovorena pitanja vezana za razvoj jednog od najvažnijih prapovijesnih razdoblja. Jedan od osnovnih ciljeva projekta HRTEC je uspostava snažne apsolutne kronološke osnove uz pomoć AMS datiranja na velikom broju „short-life“ uzoraka te modeliranjem matematičkim algoritmima kao što je „Bayesian modeling“. Daljnji cilj jest upotreba relativno širokog spektra interdisciplinarnih metoda za prikupljanje i obradu različito znanstvenih skupova podataka za izradu snažnijih, pouzdanijih te manje plastičnih arheoloških interpretacija. Fokus istraživanja biti će područje istočne Hrvatske sa specifičnim, kronološki osjetljivim nalazištima kao što su tel naselja.  Jedno od uobičajenih svojstava telova jugoistočne Europe jest činjenica da su bili spaljeni (konkretno Bapska i Bogdanovci). Snažno gorenje arhitekture, keramike, biljaka i ostalih materijalnih elementa svakodnevnog života omogućilo je u visokom postotku očuvanje kulturnih slojeva što predstavlja idealan okoliš za navedena interdisciplinarna istraživanja.  ]]></summary_hr><summary_en><![CDATA[Project Houses, Roads & Traders of the Early European Civilization (HRTEC) is designed to give answers to still unanswered principal questions related to development one of the most important Prehistoric era.  One of the main goals of HRTEC is to establish a firm absolute chronological base of the Late Neolithic using AMS dating performed on high amount of short-life samples and modeled with widely used mathematical algorithms such is Bayesian modeling. Second target to pursue is with the use of relatively wide range interdisciplinary methods to collect and process different sciences data sets and use them to make archaeological interpretation more firm, reliable and three dimensional. High-accumulative communities, at the dawn of human manipulation with metal ores, went through dynamic changes in relatively short period of time. Interpretation of life within frames of mentioned short periods will be our main goal.]]></summary_en></project><project>
<id>3439</id><title_hr><![CDATA[Poticanje inovativnog ponašanja zaposlenika u javnom sektoru primjenom intervencija u dizajnu posla]]></title_hr><title_en><![CDATA[Fostering innovative work behaviour of public employees by using work design interventions]]></title_en><user_id>5575</user_id><user_firstLast_name>Tomislav Hernaus</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2014-09</proposal_call><code>UIP-2014-09-3909</code><acronim><![CDATA[INPUBWORK]]></acronim><duration>01.06.2015 - 30.09.2018</duration><status>Završio</status><financ_value>21.210,43 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, Psihologija, </scie_field_hr><scie_field_en>Economy, Psychology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Ekonomski fakultet u Zagrebu]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Economics and Business]]></institution_en><team_members_id>7317, 13145, 12896, 6198, 6242, 22840, </team_members_id><team_members_names><![CDATA[Nina Pološki Vokić, Miha Skerlavaj, Matej Černe, Ana Aleksić, Maja  Tadić, Matija Marić, ]]></team_members_names><keywords_hr><![CDATA[dizajn posla, inovativno ponašanje zaposlenika, intervencije posla, javna poduzeća, longitudinalno istraživanje, kvazi-eksperimenti, tjedni dnevnici]]></keywords_hr><keywords_en><![CDATA[work design, innovative work behaviour, job interventions, state-owned enterprises, longitudinal research, quasi-experiments, weekly diary study]]></keywords_en><summary_hr><![CDATA[Optimalno korištenje inovacijskog potencijala zaposlenika predstavlja glavni izazov upravljanja ljudskim potencijalima u današnjem globalnom i hiperkonkurentnom poslovnom okruženju. Nedavna istraživanja potvrdila su ulogu karakteristika posla kao ključnog prethodnika i usmjeravajućeg elementa za poticanje inovativnog ponašanja zaposlenika. Ipak, još uvijek ne znamo kako se različite karakteristike posla mijenjaju tijekom vremena, kakav je njihov međusobni odnos, koje su karakteristike najvažnije te kako ih je moguće uspješno mijenjati.Inovativno ponašanje zaposlenika posebice je važno i nedovoljno istraženo u javnim poduzećima. Nažalost, njihovi zaposlenici u velikoj mjeri su demotivirani i neproduktivni, dok su njihove organizacije neefikasne i nekonkurentne. Takvi negativni stavovi i loše radne prakse ograničavaju inovativno ponašanje i pružaju neadekvatne poslovne rezultate. Slijedom toga, svrha projekta je istražiti što potiče inovacije na razini posla. Planiramo provesti dubinsko istraživanje prakse dizajna posla u Republici Hrvatskoj. Analizirat ćemo karakteristike zadataka, socijalne i kognitivne aspekte poslova unutar četiri javna poduzeća od posebnog državnog značaja.Prilagođene intervencije posla (menadžerski, idiosinkratski dogovori, dorađivanje posla) bit će provedene u stvarnom radnom okruženju, zajedno s trofaznim longitudinalnim istraživanjem putem dnevnika i kvazi-eksperimentalnim nacrtom istraživanja. Pomoću intervencija u dizajnu posla, određene karakteristike posla bit će prilagođene i usklađene s osobnim i pozicijskim karakteristikama zaposlenika. Ostvarivanjem sklada između osobe i posla, potaknut će se inovativno ponašanje javnih zaposlenika, a time će se neizravno povećati i organizacijska inovativnost. Točnije, participativno akcijsko istraživanje osigurat će višu razinu generiranja ideja te dovesti do češćih procesnih unapređenja u promatranim javnim poduzećima, s mogućim učinkom prelijevanja i na druga javna poduzeća, a na dobrobit cjelokupnog hrvatskog gospodarstva.]]></summary_hr><summary_en><![CDATA[Optimally utilizing the innovative potential of employees has become a major human resource challenge within the global and highly competitive business environment. Recent studies have confirmed job characteristics as a critical antecedent and a driving force for innovative work behaviour. However, we still know little about how work design factors change over time, how they interact, which are the most important, and how they can be successfully changed.Innovative work behaviour is especially needed and understudied within state-owned enterprises. Their employees are largely unmotivated and unproductive, and organisations are ineffective and non-competitive. Such negative work attitudes and practices hinder innovative work behaviour and result in non-adequate business results. Therefore, the main purpose of the project is to explore the idea of what enhances innovation at the work level. We plan to carry out an in-depth research on work design in Croatia. We will analyse task-, social- and cognitive aspects of jobs within four strategically important state-owned enterprises. Tailored job interventions (e.g., managerial, I-deals, job crafting) will be used in a real life work setting, supplemented with three-way longitudinal diary study and quasi-experimental research design. Through work design interventions, particular set of job characteristics will be modified and aligned with personal- and job-related differences. By achieving a person-job fit, we will be able to foster innovative work behaviour of public employees, and thereby indirectly increase the level of organisational innovativeness. Specifically, the participatory action research applied will provide increased level of idea generation and will result in more frequent process improvements within sampled state-owned enterprises, with a potential spillover effect on other SOEs and significant benefits for the Croatian economy as a whole.]]></summary_en></project><project>
<id>3442</id><title_hr><![CDATA[Razvoj materijala za 3D tiskanje mikroreaktora]]></title_hr><title_en><![CDATA[Development of materials for 3D printing of microreactors]]></title_en><user_id>5338</user_id><user_firstLast_name>Domagoj Vrsaljko</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2014-09</proposal_call><code>UIP-2014-09-3154</code><acronim><![CDATA[3Dmicroreactors]]></acronim><duration>01.07.2015 - 30.06.2018</duration><status>Završio</status><financ_value>90.250,18 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Kemijsko inženjerstvo, </scie_field_hr><scie_field_en>Chemical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet kemijskog inženjerstva i tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Chemical Engineering and Technology]]></institution_en><team_members_id>4425, 1529, </team_members_id><team_members_names><![CDATA[Krunoslav Žižek, Ivana Grčić, ]]></team_members_names><keywords_hr><![CDATA[mikroreaktori, 3D tisak, kompoziti, katalitički materijali, polimerne mješavine]]></keywords_hr><keywords_en><![CDATA[microreactors, 3D printing, kompoziti, catalytic materials, polymer blends]]></keywords_en><summary_hr><![CDATA[Tehnologija 3D tiska je relativno jeftin, automatiziran, i prilagodljiv način koji omogućuje laboratorijima i malim poduzećima pristup kemijsko-inženjerskim alatima, poput onih u velikim industrijskim okruženjima. 3D tiskanje se sastoji od izrade trodimenzionalnih fizičkih objekata iz digitalnih modela. 3D pisač koristi virtualni dizajn izrađen računalnim programom (CAD) i reproducira sloj-po-sloj do konačnog  objekta. Značajna prednost ove tehnike je u tome  što se konstrukcija objekta može jednostavno kontrolirati. Cilj projekta 3Dmicroreactors je istraživanje i razvoj polimernih kompozitnih materijala za upotrebu u 3D tiskanju mili- i mikroreaktora složene strukture. Članovi 3Dmicroreactors projektnog tima dolaze sa 4 različita zavoda kao stručnjaci u različitim područjima znanosti o materijalima i kemijskog inženjerstva, što jamči multidisciplinarnost i interdisciplinarnost projekta. U projektu 3Dmicroreactors ćemo pomoću polimernih kompozitnih materijala izraditi mikroreaktore s velikom preciznošću, uključujući složenu geometriju i zamršene unutarnje strukture, kao što su kanali s jasno definiranim dimenzijama . Nadalje, integracija senzora i katalizatora u građevnom materijalu, te razumijevanje odnosa svojstava materijala/katalizatora i kinetike procesa omogućit će projektiranje opreme, dopuštajući nam kombinaciju novih materijala i reakcijskih mehanizama  u inovativnom dizajnu reaktora. Budući da proces proizvodnje potrebnih dijelova traje kratko, jedan od rezultata projekta bit će i jeftina procedura za izradu protočnih uređaja. Tehnologija 3D tiska omogućit će kemijskim inženjerima jednostavan dizajn i osmišljavanje vlastitih reaktorskih sustava pritiskom na nekoliko tipki, nasuprot dosadašnjoj proizvodnji specijaliziranih reaktora od stakla.]]></summary_hr><summary_en><![CDATA[3D printing technology is a relatively cheap, automated, and customizable method that will make possible for synthetic laboratories and small companies to access chemical engineering tools typically used only in large-scale industrial settings. 3D printing consists of the fabrication of three-dimensional physical objects from a digital model. The 3D printer takes the virtual design from computer-aided design (CAD) software and reproduces it layer-by-layer until the physical definition of the layers gives the designed object. The significant advantage of this technique is that the architecture can be concisely controlled. Aim of the 3Dmicroreactors project is research and development of polymeric composite materials for use in 3D printing of intricate milli- and microreactors. The 3Dmicroreactors project team members come from 4 different departments and are specialists in different parts of materials and chemical engineering, guaranteeing multidisciplinarity and interdisciplinarity of the project.In the 3Dmicroreactors project we will, by using polymeric composite materials, build microreactors with high precision, including complex geometries and intricate internal structures - such as channels with well-defined size dimensions. Furthermore, integration of sensors and catalysts in the construction material, and understanding material properties and kinetics of the processes will enable the designing of the reactionware, allowing us to combine additional materials and kinetic knowledge with reactor designs. The additive manufacturing process of the devices takes a short time and will result in a cheap procedure for the fabrication of fluidic devices.3D printing technology will enable chemical engineers to design and fabricate their own inexpensive reaction vessels with the push of a few buttons opposing to paying experts for production of intricate glassware and specialized reactors.]]></summary_en></project><project>
<id>3451</id><title_hr><![CDATA[Glikozilacija plazmatskih proteina u razumijevanju dijabetesa tipa 1]]></title_hr><title_en><![CDATA[Human plasma glycome in comprehension of type 1 diabetes]]></title_en><user_id>11174</user_id><user_firstLast_name>Olga Gornik</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2014-09</proposal_call><code>UIP-2014-09-7769</code><acronim><![CDATA[GLYCO-T1D]]></acronim><duration>01.09.2015 - 31.12.2018</duration><status>Završio</status><financ_value>128.323,05 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Farmacija, Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Pharmaceutical sciences, Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Farmaceutsko-biokemijski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Pharmacy and Biochemistry]]></institution_en><team_members_id>5428, 5021, 13573, 5952, 5164, </team_members_id><team_members_names><![CDATA[Genadij Razdorov, Iva Mucalo, Tamara  Pavić, Toma Keser, Dario Rahelic, ]]></team_members_names><keywords_hr><![CDATA[glikozilacija, dijabetes tipa 1, glikom, genom, predispozicija]]></keywords_hr><keywords_en><![CDATA[glycosylation, type 1 diabetes, gycome, genome, predisposition]]></keywords_en><summary_hr><![CDATA[Glikozilacija je važna posttranslacijska modifikacija proteina koja često ima utjecaj na funkciju proteina. Proces glikozilacije je izrazito složen i reguliran mrežom gena koji su pokazali povezanost i s različitim bolestima. Glikani predstavljaju dobre potencijalne dijagnostičke alatke te doprinose razumijevanju etiologije mnogih bolesti. Značaj glikozilacije u dijabetesu tipa 1 (T1D) do sada nije istražen.T1D je oblik dijabetesa koji se javlja zbog autoimunog uništavanja stanica koje proizvode inzulin. Nedostatak brige za ove pacijente može biti letalan, stoga svako novo saznanje o ovoj bolesti predstavlja značajan doprinos. Povezivanje promjena u glikomu s genotipovima moglo bi rezultirati važnim rezultatima te potencijalno svrstati osobe u skupine bazirano na njihovim glikanskim i genomskim osobinama. Ova informacija bi se također mogla upotrijebiti za predviđanje rizika za razvoj bolesti kod pojedinca. Stoga ćemo u ovom istraživanju spojiti naša iskustva u genetičkim analizama i analitici glikana kako bismo identificirali glikanske promjene specifične za T1D za koje možemo kolerirati glikom i genom.Kako bi ostvarili cilj ovog istraživanja, analizirat ćemo glikane plazme obitelji s barem dvoje bolesnih potomaka te također zdravim potomcima. Uslijed ovisnosti glikana o godinama, roditelji neće biti uključeni u ovu studiju, pa će se tako analizirati preko 4500 dostupnih uzoraka. Za sve sudionike postoje rezultati genotipizacije.Glikani će se analizirati visokoprotočnom MALDI-TOF MS tehnologijom koja pruža pouzdanu analizu glikoma te je trenutno najsuvremenija glikoanalitička metoda.Uslijed neupitne uloge glikana u patološkim stanjima, izuzetno dobro definirane populacije izabrane za ovo istraživanje te upotrebu suvremene i osjetljive tehnologije, ovo istraživanje rezultirat će novim znanjima koja će unaprijediti razumijevanje i dijagnostiku dijabetesa tipa 1.]]></summary_hr><summary_en><![CDATA[Glycosylation is a posttranslational modification that provides great proteomic diversity and often impact protein function. This process is regulated by a network of genes, many of which show pleiotropy with different diseases. Glycans present a great potential diagnostic tool as well as contribute to the understanding of the aetiology of diseases. The importance of glycosylation in type 1 diabetes mellitus (T1D) has not been addressed by now. T1D is a form of diabetes that results from the autoimmune destruction of the insulin-producing beta cells in the pancreas. Lack of care for these patients can be lethal, so any new knowledge about the development of this disease would represent an important contribution. Integrating glycomic changes with the subjects’ known genotypes could generate powerful and important results, potentially defining groups based on their glycome and genomic characteristics. This information may also be used to predict an unaffected individual’s risk of disease. This is why, in this study, we will combine expertise in genetic analysis and analyses of plasma glycome in order to search for the glycomic changes that are specific to T1D and for which we can correlate glycome and genome.To reach the goals of this study, we will analyze plasma glycomes of families with both diabetic siblings and unaffected siblings. Due to the age-related changes in glycosylation, parents will not be included in this study, so over 4500 samples will be analysed. All these samples have their genotyping performed.Glycomes will be analysed using MALDI-TOF-MS technology, which provides reliable analysis and presents the best available glycoanalytic tool.Thus, due to the undeniable role of glycans in pathological conditions, the well characterized population selected for this study and the use of highly modern and sensitive technology, this study will result in important new insights that will advance the comprehension and management of type 1 diabetes mellitus.]]></summary_en></project><project>
<id>3452</id><title_hr><![CDATA[Vizualiziranje nacionalnog. Bratovštine i kolegiji Schiavona/Illira u Italiji i razmjena umjetničkih iskustava s jugoistočnom Europom (15. - 18. st.)]]></title_hr><title_en><![CDATA[Visualizing Nationhood: the Schiavoni/Illyrian Confraternities and Colleges in Italy and the Artistic Exchange with South East Europe (15th - 18th c.)]]></title_en><user_id>5486</user_id><user_firstLast_name>Jasenka Gudelj</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-2305</code><acronim><![CDATA[VisNat]]></acronim><duration>01.07.2015 - 30.06.2018</duration><status>Završio</status><financ_value>55.863,03 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Povijest umjetnosti, Povijest, Religijske znanosti, </scie_field_hr><scie_field_en>Art history, History, Religion, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>764, 3408, 13417, 762, 13442, 13527, </team_members_id><team_members_names><![CDATA[Danko Šourek, Daniel Premerl, Giuseppe Capriotti, Tanja Trška, Anita Ruso, Francesca Coltrinari, ]]></team_members_names><keywords_hr><![CDATA[Schiavoni/Illiri, bratovštine, kolegij, Rim, Venecija, Bologna, Marche, umjetnost]]></keywords_hr><keywords_en><![CDATA[Schiavoni/Illyrians, confraternity, college, Rome, Venice, Bologna, Marche, art]]></keywords_en><summary_hr><![CDATA[    Prve poznate organizirane skupine imigranata pristiglih iz povijesnih hrvatskih zemalja koji su dijelili isti jezik i istu katoličku vjeru spominju se u Italiji od 15. stoljeća, a okupljale su ih nacionalne bratovštine u Rimu, Veneciji, Recanatiju, Fanu, Loretu i Udinama, dok su institucionalnu potporu studentima talijanskih sveučilišta istoga podrijetla osiguravali kolegiji u Bolonji, Loretu i Fermu.Arhitektonske značajke građevina kojima su se koristile ove ustanove, kao i slikarska i kiparska djela koja su naručivali njihovi članovi, igrali su važnu ulogu u stvaranju kulturnoga identiteta ovih nacionalnih zajednica. Namjera je projekta proučiti konstruiranje svojstvenih kulturnih identiteta izraženih kroz umjetnička djela i arhitekturu institucija Schiavona/Ilira od 15. do 18. stoljeća, kroz istraživanje povijesnih naracija artikuliranih u vizualnom obliku. Ova će povijesno-umjetnički fenomeni biti promatrani u komparativnome svjetlu odnosno u kontekstu sličnih izričaja “nacionalnih” zajednica stranaca u Italiji. Osim pomne povijesno-umjetničke analize postojećih i dokumentiranih djela vizualnih umjetnosti navedenih nacionalnih institucija u Italiji, posebna će pažnja biti posvećena dinamici narudžbi umjetničkih djela od talijanskih umjetnika za regiju u kojoj se nalazi današnja Hrvatska, upravo kroz mrežu osobnih odnosa članova bratovština i alumna kolegija. Ovo će istraživanje pružiti nove spoznaje o kruženju ukusa i znanja kao i o utjecaju različitih talijanskih umjetničkih tržišta na situaciju u jugoistočnoj Europi, posebno na području današnje Hrvatske, obogaćujući pritom razumijevanje umjetničke baštine u konstrukciji proto-nacionalnih identiteta u europskom kontekstu.]]></summary_hr><summary_en><![CDATA[  The first known organized groups of people originating from historic Croatian lands sharing a common language and Catholic faith are mentioned in Italy from the 15th century. They congregated in the “Schiavoni/Illyrian” confraternities in Rome, Venice, Recanati, Fano, Loreto and Udine, while institutionalized assistance for students of the same origin attending Italian universities during the Early Modern period was provided by the “national” colleges in Bologna, Loreto and Fermo. The architecture of buildings used by these institutions, as well as paintings and sculpture and other works of art commissioned by their members, played an important role in the construction of the cultural identity of these immigrant communities. The aim of the project is to investigate the construction of intrinsic cultural identities that found their expression in the art and architecture of Schiavoni/Illyrian institutions over the centuries, through the exploration of historical narratives articulated in terms of visual arts. These art-historical phenomena are to be regarded in comparative perspective as well as in context of similar expressions found in “national” institutions of other foreign communities in Italy.In addition to in-depth art-historical analysis of the surviving and/or documented art and architecture of the said national institutions in Italy, special attention will be placed on the dynamics of artistic commissions, along with the issue of confraternity members or college alumni as possible mediators in Croatian patrons’ commissions from Italian artists. This research will provide a new insight on the circulation of taste and knowledge as well as on the impact of different Italian art markets on the art in the South-East Europe, particularly in the present-day Croatia, enriching the understanding of the role of artistic heritage in the construction of proto-national identity in the European context.]]></summary_en></project><project>
<id>3456</id><title_hr><![CDATA[Aromatski hidrazoni: sinteza, strukturna analiza, biološka aktivnost i analitička primjena]]></title_hr><title_en><![CDATA[Aromatic hydrazones: synthesis, structural analysis, biological activity and analytical application]]></title_en><user_id>851</user_id><user_firstLast_name>Nives Galić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-4841</code><acronim><![CDATA[ARHYD]]></acronim><duration>04.01.2016 - 03.01.2019</duration><status>Završio</status><financ_value>79.633,69 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>2809, 1457, 4752, 3061, 1237, 184, 5113, 1175, 5072, 1204, 1360, 19814, </team_members_id><team_members_names><![CDATA[Snežana Miljanić, Vasile Chis, Ivan Kosalec, Ana Budimir, Nevenka Poje, Darko Kontrec, Martina Rožmarić Mačefat, Adriana Kenđel, Matea Krmpotić, Tomislav Benković, Astrid Gojmerac Ivšić, Marijana Pocrnić, ]]></team_members_names><keywords_hr><![CDATA[Hidrazoni, kompleksi, struktura, kemija otopina, ekstrakcija, radiometrija, MS, NMR, UV-Vis, fluorescencija, IR, Raman, teorijsko istraživanje]]></keywords_hr><keywords_en><![CDATA[Hydrazones, complexes, structure, solution chemistry, extraction, radiometry, MS, NMR, UV-Vis, fluorescence, IR, Raman, theoretical study]]></keywords_en><summary_hr><![CDATA[Glavni cilj ovog projekta je razvoj novih metoda određivanja iona metala, kao i novih ekstrakcijsko-kromatografskih materijala za odjeljivanje nekih važnih radionuklida. Aktivne komponente u takvim sustavima bit će derivati aromatskih hidrazona koji će se pripraviti kondenzacijskim reakcijama hidrazida i različito supstituiranih aldehida ili ketona.Budući da različiti tautomerni i izomerni oblici hidrazona mogu imati i različita svojstva vezanja metala, za uspješnu primjenu ovih spojeva neophodno je detaljno proučiti navedene ravnoteže, što će se i provesti u okviru ovog projekta. Odredit će se konstante protoniranja i kinetika hidrolize u smjesama otapala s vodom. Za strukturnu karakterizaciju liganada u otopini koristit će se spektrometrija masa, tekućinska kromatografija i različite spektroskopske tehnike (NMR, UV-Vis, fluorescencija, IR i Ramanova spektroskopija). Također će se provesti i teorijska istraživanja.U otopini će se istražiti reakcije kompleksiranja hidrazona i odabranih iona metala i radionuklida. Gdjegod će to biti moguće, odredit će se konstante stabilnosti i izolirati kompleksni spojevi u čvrstom stanju. Na temelju dobivenih rezultata razvit će se spektrofotometrijske i/ili spektrofluorimetrijske metode određivanja iona metala. Selektivnost predloženih metoda poboljšat će se uvođenjem ekstrakcije tekuće-tekuće pri čemu će se proučiti utjecaj površinski aktivnih tvari na djelotvornost postupka. Nadalje, istražit će se sposobnost hidrazona kao ekstrakcijsko-kromatografskih smola za odjeljivanje radionuklida.U okviru projekta također će se odrediti biološka aktivnost pripravljenih hidrazona i njihovih kompleksnih spojeva prema odabranim bakterijskim i gljivičnim vrstama.Na kraju će se korelirati struktura hidrazona s njihovim fizičko-kemijskim svojstvima, što je od osobitog značaja za njihovu uspješnu primjenu kao biološki aktivnih spojeva ili analitičkih reagensa. ]]></summary_hr><summary_en><![CDATA[The main goal of the project is to develop new methods for metal ions determination as well as new extraction chromatographic materials for separations of some important radionuclides. The active components in such systems will be aromatic hydrazone derivatives. They will be synthesized by condensation reactions of hydrazide and differently substituted aldehydes or ketones.Since different tautomeric and isomeric forms of hydrazones can have diverse chelating properties, the detailed study of the corresponding equilibria is important for successful application of these compounds and will be performed within the project. Protonation properties and kinetics of hydrolysis of hydrazones in solvents containing water will be examined. For structural characterization of ligands in solution mass spectrometry, liquid chromatography, and different spectroscopic techniques (NMR, UV-Vis, fluorescence, IR and Raman spectroscopy) will be used. The computational studies will be carried out as well.The complexation reactions of hydrazones with selected metal ions and radionuclides will be investigated in solution. Whenever possible, complex stability constants will be determined and solid complexes will be isolated. Based on the results obtained, spectrophotometric and/or spectrofluorimetric methods for metal ions determination will be developed. The selectivity of the proposed methods will be further improved using extraction procedure. The influence of surfactants on the extraction systems will be explored. Furthermore, hydrazones abilities as extraction chromatographic resins towards selected radionuclides will be investigated.Prepared hydrazones and their complexes will be screened for biological activity on selected microbial species and fungi.Finally, the correlation of the hydrazones structures and their physico-chemical properties will be proposed, which is of great importance for successful applications of such compounds as bioactive agents or analytical reagents.]]></summary_en></project><project>
<id>3458</id><title_hr><![CDATA[Uloga estrogen i androgen receptora u aktivaciji strome oralnog karcinoma i njihov utjecaj na peživljavanje bolesnika]]></title_hr><title_en><![CDATA[The role of estrogen and androgen receptors in active stroma of oral cancer and its influence on patients survival]]></title_en><user_id>12809</user_id><user_firstLast_name>Vanja  Vučićević Boras</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-6985</code><acronim><![CDATA[ACTIVSTROMORALCANCER]]></acronim><duration>01.10.2015 - 30.09.2019</duration><status>Prekinut</status><financ_value>46.452,98 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Kliničke medicinske znanosti, Javno zdravstvo i zdravstvena zaštita, </scie_field_hr><scie_field_en>Clinical sciences, Public health and health services, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Stomatološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Dentistry]]></institution_en><team_members_id>2654, 12334, 13606, 2696, 13614, 6833, 6702, 7482, </team_members_id><team_members_names><![CDATA[Aleksandra Fučić, Dragana Gabrić Pandurić, Antun Major, Zoran Rakušić, Vesna Bišof, Danko Velimir  Vrdoljak, Čedna Tomasović-Lončarić, Mihajlo Virag, ]]></team_members_names><keywords_hr><![CDATA[oralni karcinom, estrogen, androgen, citokini, stroma]]></keywords_hr><keywords_en><![CDATA[oral cancer, estrogen, androgen, cytokines, stroma]]></keywords_en><summary_hr><![CDATA[Učestalost oralnog karcinom pločastih stanica (OKPS) u Hrvatskoj je 8,4 osobe na 100.00 stanovnika. Najveća učestalost ovog karcinoma je u muškaraca iznad 50 godina starosti. Znakovito povećani rizik za razvoj oralnog karcinoma imaju pušači i osobe koje svakodnevno konzumiraju alkohol. OKPS je agresivni karcinom koji brzo metastazira (oko 50% oboljelih ima pri postavljanju dijagnoze metastaze u limfnim čvorovima) te je uspješna dijagnostika od velike važnosti za učinkovitu terapiju. Unatoč razvoju novih terapijskih pristupa u liječenju ovog karcinoma ne bilježi se značajni porast petogodišnjeg preživljavanja zadnjih desetljeća. Standardni oblici liječenja su kirurške disekcije uz liječenje zračenjem, a kemoterapija se rjeđe primjenjuje. Najnovija istraživanja ukazuju da je uz histološki nalaz OKPS od velikog značaja i procjena aktivnosti strome samog tumora koja može sadržavati stanice koje ispuštaju signalne molekule ključne za razvoj metastaza. Cilj ovog projekta je pridonijeti saznanjima o broju i aktivaciji stanica u stromi OKPS-a u odnosu na preživljavanje bolesnika. Istraživanje će se zasnivati na arhivskim bioptatima, a uključit će procjenu razine receptora na malignim stanicama i stanicama strome tumora (androgeni,estrogeni), metaloproteinaza 9, citokina(IL-1beta, IL-6), vaskularnog endotelnog čimbenika rasta i čimbenika hipoksije te čimbenika proliferacija Ki67. Očekivani rezultati pridonijet će poboljšanju informativnosti histološkog nalaza i individualnom pristupu liječenja OKPS-a. Putem upitnika ispitati će se životne navike bolesnika, izloženost te obiteljska anamneza i njihov mogući utjecaj na histološki profil OKPS-a. U okviru projekta izradit će se web stranica sa rezultatima projekta, bazom tekućih istraživačkih projekata, kliničkih studija, relevantni publikacija i forumom. Web stranica će pridonijeti boljoj suradnji kliničara i drugih zainteresiranih eksperata, a u svrhu boljitka za bolesnike kao i budućoj međunarodnoj prepoznatljivosti. ]]></summary_hr><summary_en><![CDATA[The incidence of oral squamous cell carcinoma (OSCC) in Croatia is 8.4 persons per 100.00 inhabitants. The highest incidence of cancer is in men over 50 years of age. Significantly increased risk of developing OSCC is among smokers and people who daily consume alcohol. OSCC is an aggressive cancer that metastasizes (about 50% of patients have at diagnosis lymph node metastases) thus the successful diagnosis is of major importance for effective therapy. Despite the development of new therapeutics in the treatment of OSCC, no significant increase in five-year survival has been recorded in the past decade. Standard algorithms of treatment include surgical dissection with radiotherapy, while chemotherapy is rarely applied. The latest research suggests that in OSCC is of great importance the evaluation of tumor stroma activation, as it may contain cells that produce signaling molecules crucial for the development of metastases. The aim of this project is to obtain insight into activated cells in the stroma of OSCC in relation to patient survival. The study will be based on archived tissues, and will involve assessing the level of receptor on malignant cells and stromal tumors (androgens, estrogens), metaloproteinase 9, cytokines (IL-1 beta, IL-6), vascular endothelial growth factor, hypoxia factors and factors Ki67 proliferation. The expected result will contribute to histological diagnostics and enable individual approach of OSCC therapy. Through questionnaires will be examined the lifestyle habits of patients, exposures, family history and their possible impact on the OSCC histological profile. Within the project a website will be developed which will contain results of the project, the base of current research projects, clinical studies, relevant publications and a forum. The website will contribute to better cooperation between clinicians and other interested experts, and bring benefit for patients as well as future international recognition]]></summary_en></project><project>
<id>3459</id><title_hr><![CDATA[Kanali i učinkovitost fiskalnih devalvacija]]></title_hr><title_en><![CDATA[Channels and effectiveness of fiscal devaluations]]></title_en><user_id>983</user_id><user_firstLast_name>Goran Vukšić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-7017</code><acronim><![CDATA[FIDE]]></acronim><duration>01.09.2015 - 31.08.2019</duration><status>Završio</status><financ_value>18.488,29 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, </scie_field_hr><scie_field_en>Economy, </scie_field_en><institution_hr><![CDATA[Institut za javne financije]]></institution_hr><institution_en><![CDATA[Institute of Public Finance]]></institution_en><team_members_id>13280, 606, 603, </team_members_id><team_members_names><![CDATA[Mario Holzner, Marina Tkalec, Maruška Vizek, ]]></team_members_names><keywords_hr><![CDATA[fiskalna politika, izvoz, konkurentnost, oporezivanje, Europska Unija]]></keywords_hr><keywords_en><![CDATA[fiscal policy, exports, competitiveness, taxation, European Union]]></keywords_en><summary_hr><![CDATA[Fiskalna devalvacija može se opisati kao kombinacija fiskalnih politika s neutralnim učinkom na proračun, a koja bi trebala oponašati učinke devalvacije nominalnog valutnog tečaja, tj. poboljšati vanjsku konkurentnost zemlje i povećati neto izvoz. Nakon početka recentne ekonomske krize, fiskalne devalvacije postale su prioritetna tema u diskusijama ekonomske politike u Europi. Te diskusije se uglavnom odnose na zemlje članice Europske Monetarne Unije, ali je tema vrlo relevantna i za širi skup zemalja, uključujući one koje su možda izvan monetarnih unija, ali provode politiku fiksnog valutnog tečaja (npr. Hrvatska). Postoji, međutim, značajan jaz u znanstvenom istraživanju fiskalnih devalvacija. Najveći dio postojećih studija sastoji se od simulacijskih analiza čiji su rezultati određeni specifikacijama i kalibracijama modela. Ekonometrijske studije, s druge strane, koje bi mogle odgovoriti na pitanja o učinkovitosti i kanalima fiskalnih devalvacija u praksi i dalje su rijetke. Predloženo istraživanje namjerava popuniti neke od praznina u postojećoj literaturi pružajući nove ekonometrijske rezultate u unaprijeđenom ekonometrijskom pristupu testiranju hipoteze o učinkovitosti fiskalnih devalvacija, te istraživanjem relevantnosti nekih pojedinačnih kanala kroz koje bi fiskalna devalvacija trebala djelovati. Predloženo istraživanje podijeljeno je u četiri segmenta: 1) Testiranje učinkovitosti fiskalnih devalvacija u EU koristeći bilateralne trgovinske podatke; 2) Testiranje učinka fiskalne devalvacije na realne valutne tečajeve; 3) Testiranje postojanja razlika u učincima fiskalnih devalvacija za industrije s različitim intenzitetom rada u proizvodnji; 4) Testiranje učinka smanjenja doprinosa za socijalno osiguranje (i cjelokupnog poreznog opterećenja rada) na plaće. Naš uzorak uključuje sve zemlje EU za koje su dostupni podaci. Također ćemo uzeti u obzir razdoblje recentne krize tijekom koje su mnoge zemlje EU provele reforme poreznih sustava.]]></summary_hr><summary_en><![CDATA[Fiscal devaluation can be described as a budget-neutral mix of fiscal policies which should mimic the effects of nominal exchange rate devaluation, i.e. bring improvements in country’s external competitiveness and increase net exports. After the outset of the recent economic crisis, fiscal devaluations have become priority topic in economic policy discussions in Europe. These discussions are mostly related to European Monetary Union member states, but the topic is highly relevant for a broader set of countries, including those which may be outside currency unions, but pursue fixed exchange rate policy (e.g. Croatia). There are, however, significant gaps in the scientific research of fiscal devaluations. The largest part of related contributions consists of simulation studies, whose results are driven by model specifications and calibrations. The econometric studies, on the other hand, which could provide answers on the effectiveness and channels of fiscal devaluations in practice, remain very scarce. The proposed research aims to fill some of the gaps in the literature, by providing new econometric evidence in an improved econometric approach to testing the hypothesis of the fiscal devaluation effectiveness, and by examining the relevance of some of the specific channels through which fiscal devaluations should work. The proposed research is divided into four segments: 1) Testing the effectiveness of fiscal devaluations in the EU using bilateral trade data; 2) Testing the impact of fiscal devaluation on real exchange rates; 3) Testing whether the effects of fiscal devaluations vary for industries with different labor intensity in production; 4) Testing the impact of cuts in social security contributions (and overall tax burden on labor) on wages. Our sample will include all EU countries for which data is available. We shall also consider the period of the recent crisis during which many EU countries implemented reforms of taxation systems. ]]></summary_en></project><project>
<id>3460</id><title_hr><![CDATA[Uspostava dugoročnog znanstvenog monitoringa prirodnih šumskih ekosustava u Hrvatskoj]]></title_hr><title_en><![CDATA[Establishing Long-Term Scientific Monitoring of Natural Forest Ecosystems in Croatia]]></title_en><user_id>3754</user_id><user_firstLast_name>Stjepan Mikac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-1834</code><acronim><![CDATA[CroFEM]]></acronim><duration>01.09.2015 - 31.08.2018</duration><status>Završio</status><financ_value>86.488,82 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Šumarstvo, Biotehnologija, </scie_field_hr><scie_field_en>Forestry, Biotechnology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet šumarstva i drvne tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Forestry and Wood Technology]]></institution_en><team_members_id>12598, 12604, 13634, 13518, 13679, 12394, 12615, 13592, 13587, 13583, 12737, 13572, 13636, 13672, 12981, 13529, 12827, 13542, 12710, 13749, 13764, 8749, 25182, </team_members_id><team_members_names><![CDATA[Irena Šapić, Joso Vukelić, Antun Alegro, Tomislav Levanič, Željko Španjol, Darko Bakšić, Damir Ugarković, Stanislav Kucbel, Peter Jaloviar, Miroslav Balanda, Mislav Vedriš, Ernest Goršić, Nera Bakšić (rođ. Marković), Milan Oršanić, HRVOJE BARAĆ, Dušan Roženbergar, Vinko Paulić, Thomas Andrew Nagel, Damir Drvodelić, Jurij Diaci, Hubert Hasenauer, Mario Šango, Ljubica Lukač, ]]></team_members_names><keywords_hr><![CDATA[ekstenzivni monitoring, intenzivni monitoring, prašume, dinamike prašuma, dugoročna promjene]]></keywords_hr><keywords_en><![CDATA[extensive monitoring, intensive, old-growth forest, forest dynamic, long-term changes]]></keywords_en><summary_hr><![CDATA[Hrvatska, u usporedbi s većinom Srednjoeuropskih zemalja, ima razmjerno prirodne šumske sa brojnim visoko vrijednim lokalitetima koji posjeduju karakter izvornih prašuma. Ideja o sustavnom multidisciplinarnom ekološkom monitoringu u Hrvatskoj pojavila se 1965. godine, no nije uspješno realizirana. Na osnovi te ideje, te potaknuto povećanjem sveukupnog interesa za praćenje promjena i dinamike prirodnih ekosustava, početkom 80-tih godina osnovane su trajne plohe po načelima UNESCO-vog programa MAB (Man and the Biosphere Programme). Nadahnuti potrebom za boljim razumijevanjem prirodne dinamike šumskih ekosustava i dugoročnim praćenjem promjena predlažemo ovaj projekt sa ciljem uspostave dugoročnog znanstvenog monitoringa, uz revitalizaciju postojećih i osnivanje novih ploha, čime će se stvoriti mreža terenskih laboratorija na kojima će sadašnji i budući znanstvenici nadograđivati svoje znanstvene kapacitete. Projektom se žele objediniti znanja i uspostaviti interdisciplinarna dugoročna istraživanja s jednim zajedničkim ciljem – razumijevanjei praćenje dinamike šumskih ekosustava. Projekt je zamišljen na dvije razine intenziteta monitoringa: 1) ekstenzivni monitoring-EM (I) i 2) intenzivni monitoring-IM (II). Ekstenzivni monitoring rezultirao bi sa 50-60 pokusnih objekata diljem Hrvatske dok bi se intenzivnim monitoringom obuhvatilo 5 najreprezentativnijih prašumskih objekata. IM treba poslužiti kao reprezentativni objekt istraživanja za sve plohe ekstenzivnoga monitoringa, dok EM omogućava procjenu u kojoj se mjeri rezultat intenzivnog monitoringa slučaja mogu generalizirati za jednaki stanišni tip, geološku podlogu, vegetacijska obilježja i slično sa relativno brzom i jeftinom izmjerom indikatora, koji pokazuju stanje ekosustava.]]></summary_hr><summary_en><![CDATA[Croatia, in comparison with most Central European countries, has a valuable forest areas with characteristics of a old-growth forest. The idea of systematic multidisciplinary, environmental monitoring in Croatia appeared in 1965. Based on these ideas, and driven by the growing interest in monitoring changes and dynamics of natural ecosystems, in early 80s the long-term, permanent monitoring plots  were established according to the principles of the UNESCO MAB program. Unfortunately, after the initial establishment, these plots were not systematically monitored. Inspired by the need for better understanding of the natural dynamics of forest ecosystems and the long-term monitoring we propose this project with the aim of establishing a long-term scientific monitoring. It  includes revitalization of existing and establishment of new monitoring plots which will,  in the end, represent a network of field laboratories where current and future researchers would build their research capacities. The project aims to consolidate knowledge and establish a long-term interdisciplinary research with one common goal – understanding and  monitoring the dynamics of forest ecosystems. The project is designed on two levels of intensity: 1) extensive monitoring-EM (I) and 2) intensive monitoring-IM (II). EM would result in the 50-60 plots across the Croatia while five of the most representative old-growth forest sites  will be the object of IM. IM should serve as a representative object of research for all plots of an EM, while EM enables the estimation of the  extent to which the results of the IM case study can be generalized for the habitat type, the geological substrate, vegetation characteristics and the like. This  by using relatively quick and inexpensive survey indicators, which show the status of ecosystem. ]]></summary_en></project><project>
<id>3462</id><title_hr><![CDATA[Zvijezde i prašina: struktura, sastav i interakcija]]></title_hr><title_en><![CDATA[Stars and dust: structure, composition and interaction]]></title_en><user_id>7697</user_id><user_firstLast_name>Krešimir  Pavlovski</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-8656</code><acronim><![CDATA[STARDUST]]></acronim><duration>01.05.2015 - 30.04.2019</duration><status>Završio</status><financ_value>126.235,32 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>12397, 11189, 13362, 13561, 13458, 13368, 12828, 22567, </team_members_id><team_members_names><![CDATA[Goranka Bilalbegović, Dubravka Kotnik-Karuza, Ettore  Tamajo, Dejan Vinković, Petar Mimica, Miljenko Čemeljić, Tomislav Jurkić, Ahmet Dervisoglu, ]]></team_members_names><keywords_hr><![CDATA[zvijezde, dvojne zvijezde, zvjezdana evolucija, akrecijski diskovi, protoplanetarni diskovi, spektroskopija]]></keywords_hr><keywords_en><![CDATA[stars, binary stars, stellar evolution, accretion disk, protoplanetary disk,  spectroscopy]]></keywords_en><summary_hr><![CDATA[Projekt se bavi zvijezdama i kozmičkom prašinom, važnim barionskim dijelom Svemira. Interakcija izmedu prašine, plina i zvijezda prisutna je kroz cijelu zvjezdanu i galaktičku  evoluciju, od nastanka zvijezda i planeta sve do konačne eksplozije supernova. U vremenu precizne kozmologije i potrage za životom na drugim svjetovima, zvjezdana astrofizika ponovno je ekstremno relevantna. Naveli smo brojne važne teme u različitim fazama zvjezdane evolucije  i interakcije zvijezda s njihovom cirkumstelarnom i interstelarnom okolinom. Naš je glavni cilj ispitivanje zvjezdanih evolucijskih modela. Pomoću naprednih metoda spektralnog raspetljavanja, koje smo pionirski koristili i unaprijedili, u stanju smo izmjeriti metalicitet zvijezda u dvojnim sustavima s velikom preciznosti i na taj način otkloniti glavnu prepreku u usporedbi empirijskih podataka s modelima. Planiramo na taj način analizirati istaknute dvojne zvijezde različitih masa kako bismo dali najstrože testove različitih zvjezdanih evolucijskih modela i baždarili učinkovitost rotacijskog miješanja, konvektivnog probijanja jezgre ili duljine miješanja tvari. Proračuni prijenosa zračenja u prašinastim omotačima i protoplanetarnim diskovima, uključujući i MHD proračune u graničnom području zvijezda-disk bit će provedeni s velikim prostornim razlučivanjem što omogućuje računalni program LELUYA kojeg je razvio jedan od nas. Ab initio DFT (funkcional gustoće) proračuni trebali bi omogućiti identifikaciju i sastav nanočestica u interstelarnoj prašini iz infracrvenih i rendgenskih spektara dobivenih opažanjima na svemirskim teleskopima. Ovo je prvi pokušaj u okupljanju raspršenih astrofizičkih istraživanja u Hrvatskoj u znantno fokusiranom smjeru. Istraživački je tim sastavljen od hrvatskih istraživača iz 6 hrvatskih i 2 strane institucije uključujući sva četiri  glavna hrvatska sveučilišta. Nadamo se da će to unaprijediti zajednička istraživanja i učiniti astrofizička istraživanja u zemlji puno koherentnijim i bolje organiziranim.]]></summary_hr><summary_en><![CDATA[This project deals with stars and cosmic dust, important baryonic constituents of the Universe.   The interplay between dust, gas and stars is present throughout stellar and Galactic evolution, from star and planet formation until ultimate final stages in supernovae explosions.    In the era of precision cosmology and of search for life on other worlds, stellar astrophysics has become extremely relevant. We address a number of important topics in the various stages of stellar evolution and interaction of stars with their circumstellar and interstellar environment. Our principal objective is probing stellar evolution models. With sophisticated methods of spectral disentangling we pioneered and upgraded we are able to measure metallicity of the stars in binaries with the high precision and breakdown the main obstacle in comparing empirical data to models. We plan to analyse benchmark binary stars along the mass sequence to provide the stringent tests of different stellar evolution models and parametrise efficiency of rotational mixing, convective core overshooting or mixing length.  Radiative transfer calculations in dusty envelopes and protoplanetary disks, including MHD calculations in boundary star-disk region would be performed with a high spatial resolution which  is enabled by the code LELUYA devolped by one of us. Ab initio quantum density functional theory calculations would enable identifications and composition of interstellar dust nanoparicles from IR and X-ray spectra obtained on-board space telescopes. This is is the first attempt to organise dispersed astrophysical research in Croatia into more focused direction. The research team is assembled with the Croatian scientist from 6 Croatian and 2 foreign institutions including all the four major Croatian universities. We hope this would promote collaborative research and make astrophysical research in the country more coherent and better organised.]]></summary_en></project><project>
<id>3464</id><title_hr><![CDATA[Razjašnjavanje sortne tipičnosti vina i maslinovih ulja od hrvatskih domaćih sorti]]></title_hr><title_en><![CDATA[Unravelling the varietal TYPIcity of wines and olive oils from CROatian native varieties]]></title_en><user_id>4924</user_id><user_firstLast_name>Igor Lukić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2014-09</proposal_call><code>UIP-2014-09-1194</code><acronim><![CDATA[TYPICRO]]></acronim><duration>01.07.2015 - 30.06.2018</duration><status>Završio</status><financ_value>75.422,41 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, Prehrambena tehnologija, </scie_field_hr><scie_field_en>Agriculture, Food technology, </scie_field_en><institution_hr><![CDATA[Institut za poljoprivredu i turizam]]></institution_hr><institution_en><![CDATA[Institute of Agriculture and Tourism in Poreč]]></institution_en><team_members_id>6511, 7005, 5679, 6369, 13450, 2790, 5191, 13660, 7171, 18945, 21020, </team_members_id><team_members_names><![CDATA[Sanja Radeka, Marijan Bubola, Karolina Brkić Bubola, Marin Krapac, Olivera Koprivnjak, Mirella Žanetić, Marina Lukić, Tomislav Plavša, Urska Vrhovsek, Sara Godena, Ivana Horvat, ]]></team_members_names><keywords_hr><![CDATA[sortna tipičnost, vino, maslinovo ulje, domaće sorte, Hrvatska, hlapljive arome, fenoli, senzorna analiza, kemometrija, tehnologija]]></keywords_hr><keywords_en><![CDATA[varietal typicity, wine, olive oil, native varieties, Croatia, volatile aroma, phenols, sensory evaluation, chemometrics, technology]]></keywords_en><summary_hr><![CDATA[Projekt TYPICRO nastoji razjasniti sortnu tipičnost vina i maslinovih ulja od hrvatskih domaćih sorti. Odabrati će se tipični uzorci te će se definirati tipične senzorne karakteristike i deskriptori od strane profesionalnih certificiranih senzornih ocjenjivača. Izraditi će se novi obrazac za kvantitativno deskriptivno senzorno ocjenjivanje tipičnosti. Uzorci tipičnih vina i maslinovih ulja od domaćih i introduciranih sorti biti će podvrgnuti detaljnom kemijskom profiliranju i kvantifikaciji pomoću mikroekstrakcije na čvrstoj fazi uz plinsku kromatografiju-spektrometriju masa (HS-SPME-GC-MS) za hlapljive spojeve arome, te tekućinske kromatografije visokog razlučivanja s detekcijom nizom dioda (HPLC-DAD) za fenole. Uzorci će se senzorno ocijeniti kvantitativnom deskriptivnom analizom. Rezultati će biti obrađeni kemometrijskim metodama. Prototipski proizvodi domaćih sorti biti će podvrgnuti dubinskoj metabolomskoj i olfaktometrijskoj (AEDA s GC-O) analizi u svrhu identifikacije novih spojeva, te određivanja hijerarhije hlapljivih sastojaka odnosno njihovog relativnog doprinosa tipičnoj aromi. Očekivani rezultati uključuju određivanje tipičnog kemijskog sastava i senzornih svojstava sortnih vina i maslinovih ulja od domaćih i introduciranih sorti, utvrđivanje fizikalno-kemijske osnove i nositelja senzorne tipičnosti, utvrđivanje biljega sortnog podrijetla za diferencijaciju između tipičnih proizvoda od domaćih i introduciranih sorti, određivanje nepromjenjivih osobina i pokazatelja sortnog podrijetla unatoč unutarsortnoj varijabilnosti, te određivanje unutarsortnih razlika. Kroz niz poljskih i tehnoloških pokusa identificirati će se čimbenici koji doprinose isticanju i očuvanju tipičnosti. Biti će ispitan stupanj prepoznatljivosti tipičnih domaćih vina i ulja među stručnjacima, znalcima i proizvođačima. Rezultati ovog projekta predstaviti će se kroz niz javnih predavanja, konferencija i radionica, te će biti objavljeni u međunarodno relevantnim znanstvenim časopisima.]]></summary_hr><summary_en><![CDATA[TYPICRO project aims to unravel the varietal typicity of wines and olive oils from Croatian native varieties. Typical wines and olive oils will be selected and their typical sensory characteristics and descriptors will be defined by professional certified tasters. A novel quantitative descriptive sensory evaluation form for the assessment of typicity will be created. Typical samples from native and introduced varieties will be subjected to chemical profiling and quantification by headspace solid-phase microextraction with gas chromatography-mass spectrometry (HS-SPME-GC-MS) for volatile aromas, and high performance liquid chromatography with diode-array detection (HPLC-DAD) for phenolics. Quantitative descriptive sensory evaluation will be performed. The results will be processed by chemometrics. The prototypical monovarietal products will be subjected to in-depth metabolomic and olfactometric analysis to identify previously unidentified compounds, and to determine the hierarchy of volatiles and their relative contribution to typical aroma. Expected results include: determination of typical chemical composition and sensory characteristics of wines and olive oils from native and introduced varieties in Croatia, determination of the physico-chemical basis and drivers of sensory typicity, determination of markers of varietal origin able to discriminate between typical products from native and introduced varieties, determination of unchanging characteristics and indicators that remain determinants of varietal origin despite intra-varietal variability, determination of intra-varietal differences. Factors that highlight and preserve varietal typicity will be identified through a set of field and technological experiments. The recognisability of typical products will be tested in blind-tasting trials. The outcomes of the project will be disseminated through public presentations, conferences and a workshop, and published in internationally relevant scientific journals.]]></summary_en></project><project>
<id>3466</id><title_hr><![CDATA[Kristalno inženjerstvo višekomponentnih metaloorganskih materijala povezanih halogenskom vezom: ususret supramolekulskom ugađanju strukture i svojstava]]></title_hr><title_en><![CDATA[Crystal engineering of multicomponent halogen bonded metal-organic materials: towards supramolecular control over structure and properties]]></title_en><user_id>356</user_id><user_firstLast_name>Dominik Cinčić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-7367</code><acronim><![CDATA[CrystEngMOM]]></acronim><duration>15.09.2015 - 14.09.2019</duration><status>Završio</status><financ_value>115.714,38 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>310, 4525, 708, 12541, 13224, 13225, 21344, 24307, 25023, 25323, </team_members_id><team_members_names><![CDATA[Vladimir Stilinović, Nenad Judaš, Zora Popović, Vinko Nemec, Tomislav Friscic, Robin Stein, Katarina Lisac, Nikola Bedeković, Matea Vitković, Luka Fotović, ]]></team_members_names><keywords_hr><![CDATA[Halogenska veza, metaloorganski materijali, kokristali, supramolekulska kemija, mehanosinteza]]></keywords_hr><keywords_en><![CDATA[Halogen bond, metal-organic materials, cocrystals, supramolecular chemistry, mechanosynthesis]]></keywords_en><summary_hr><![CDATA[Glavni cilj predloženog istraživanja je razvijanje općeg principa priprave višekomponentnih kristalnih materijala (kokristala) ugodivih svojstava koji sadrže metaloorganske jedinice povezane halogenskim vezama. Ciljana sinteza kokristala metaloorganskih spojeva s donorima halogenske veze predstavljala bi značajan doprinos ne samo kristalnom inženjerstvu već i kemiji materijala te supramolekulskoj kemiji krutina. Predloženo istraživanje otvorit će put ka sintezi novih supramolekulskih krutina kontrolirane strukture i dimenzionalnosti sastavljenih od metaloorganskih jedinica. Takvi materijali mogu imati magnetska, optička i električna svojstva različita od svojstava organskih supramolekulskih materijala. Uz temeljne spoznaje o povezivanju metaloorganskih spojeva halogenskim vezama, proučit će se mogućnost primjene takovog povezivanja u ciljanoj sintezi fotoosjetljivih materijala, navlast kokristala sposobnih prevoditi svjetlostnu energiju u mehaničku. Drugi dio predloženog projekta bit će dizajn i sinteza organskih višekomponentnih materijala povezanih halogenskim vezama. Do sada je izučavanje halogenskih veza bilo osjetno ograničeno jednoličnošću dostupnih donora halogenske veze. Predložena istraživačka skupina spaja iskustva pojedinih suradnika u kovalentnoj sintezi, koordinacijskoj kemiji te kristalnim inženjerstvu, što će omogućiti sintezu kako novih donora halogenske veze, tako i metaloorganskih akceptora te supramolekulskih krutina. Ti će spojevi omogućiti temeljno istraživanje sintonâ halogenske veze, te izučavanje pouzdanih načina izrade proširenih metaloorganskih materijala povezanih halogenskim vezama i mogućnosti priprave izostrukturnih metaloorganskih kokristala radi ugađanja svojstava materijala unošenjem samo malih promjena u zadanu arhitekturu kokristala.]]></summary_hr><summary_en><![CDATA[The principal aim of the proposed research is to develop the first general designs for the assembly of functional multicomponent crystalline materials (cocrystals) involving metal-organic units organized by way of halogen-bonding interactions. The controlled and deliberate synthesis of halogen-bonded cocrystals involving metal-organic building blocks remains an outstanding challenge of crystal engineering, materials science and solid-state supramolecular chemistry. The proposed research will open a path to synthesize new molecular materials with controlled 1-, 2- or 3-D architectures, involving metal-organic building blocks which are expected to provide access to new magnetic, optical and electrical properties not usually available in carbon-based supramolecular networks. In particular, besides establishing the fundamental aspects of the design of halogen-bonded metal-organic materials, the proposed research will explore the application of these designs in the synthesis of photoresponsive switching materials, specifically of cocrystals capable of transforming light into mechanical motion. Another element of the proposed research project will be the design and synthesis of purely organic halogen-bonded multi-component materials. The field of halogen-bonded cocrystals has so far been heavily limited by the poor availability of diverse halogen bond donor building blocks. A particular strength of the assembled research team lies in the extensive experience in covalent synthesis, coordination chemistry and crystal engineering, enabling the synthesis of new halogen bond donors of different bonding strength and directionality, which will be employed for the fundamental studies of halogen bonding synthons, of reliable strategies for the construction of extended halogen bonded metal-organic materials, and of isostructural metal-organic cocrystals as a means to fine-tune the properties of solid materials by introducing minute differences into a given cocrystal architecture.]]></summary_en></project><project>
<id>3468</id><title_hr><![CDATA[Cerebrovaskularna regulacija tijekom apneje kod elitnih ronilaca na dah]]></title_hr><title_en><![CDATA[Cerebrovascular regulation during apnea in elite breath-hold divers]]></title_en><user_id>7688</user_id><user_firstLast_name>Zeljko Dujic</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-1937</code><acronim><![CDATA[CEREBROFLOW]]></acronim><duration>28.09.2015 - 27.09.2019</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, Clinical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Split School of Medicine]]></institution_en><team_members_id>12936, 12449, 12426, 1026, 12771, 12439, 12451, 1395, 12602, 4715, 7034, </team_members_id><team_members_names><![CDATA[Phil  Ainslie, Kevin Shoemaker, Otto Barak, Tonći Batinić, Marijana Karlovic-Vidakovic, Krešimir  Čaljkušić, Ivan Drviš, Damir Fabijanić, Arne Sieber, Mihajlo Lojpur, Toni Brešković, ]]></team_members_names><keywords_hr><![CDATA[Moždani protok krvi, moždani metabolizam, hipoksija, hiperoksija, hiperkapnija, hipokapnija]]></keywords_hr><keywords_en><![CDATA[Cerebral blood flow, cerebral metabolism, hypoxia, hyperoxia, hypercapnia, hypocapnia]]></keywords_en><summary_hr><![CDATA[Glavni cilj ovog prijedloga je da se sprovedu serije sve složenijih studija kojima bi se istražila nova fiziološka pitanja u sklopu fiziologije apneje, s posebnim naglaskom na fiziologiju mozga, te integraciju s cirkulacijskim i respiracijskim refleksima. Postavljanjem  novih znanstvenih pitanja u ovom prijedlogu želimo obogatiti i nadograditi naše razumijevanje temeljnih mehanizama moždanog protoka krvi u uvjetima teške hipoksije. Raščlanjivanje prirode odnosa između kisika, cerebralne perfuzije, moždanog metabolizma, te njihove važnosti za moždanu homeostazu je ključan korak prema razumijevanju fiziologije mozga u odnosu na ostale tjelesne sustave. Zadržavanje daha uzrokuje izniman stres za kardiovaskularni sustav i mozak, usprkos kojem elitni ronioci na dah uspijevaju tolerirati značajan pad kisika koji samo u ponekim slučajevima rezultira gubitkom svijesti (sinkopa). Mehanizmi odgovorni za adaptaciju ekstremnoj hipoksiji nam mogu poslužiti kao koristan model za istraživanje cerebrovaskularne regulacije tijekom prijetnje fiziološkoj homeostazi, kao što je to slučaj kod bolesti ili traume, tim više što je samo znanstveno istraživanje regionalne moždane perfuzije tijekom kardiorespiracijskih izazova, tjelesne aktivnosti i patoloških stanja tek u svojim začecima. Prema tomu, istraživanje regionalne cerebrovaskularne regulacije, te njene povezanosti s cirkulacijskim i respiracijskim sustavom kod zdravih, treniranih ronioca na dah će rezultirati novim uvidom u cerebrovaskularnu funkciju, kao i uvidom u integraciju ostalih sustava kod ljudi. Štoviše, rasvjetljavanje ovakvih mehanizama je od izuzetno velikog značaja za razumijevanje mnogobrojnih patoloških stanja vezanih uz arterijsku hipoksemiju i/ili promjene u viskoznosti krvi ili koncentraciji hemoglobina. ]]></summary_hr><summary_en><![CDATA[The main objective of this proposal is to propose and conduct a series of incrementally progressive studies to examine new physiological questions in apnea diving physiology, with particular focus on brain physiology and the related integration with circulatory and respiratory reflexes. Addressing the novel questions outlined in this proposal will enrich our understanding of the fundamental mechanisms governing cerebral blood flow in conditions of severe hypoxia. Characterization of these relationships between oxygen, cerebral perfusion and cerebral metabolism, and their respective importance on brain homeostasis is a fundamental step toward raising our understanding of brain physiology to that of other body systems. Breath holding exerts a potent stress to the cardiovascular system and brain, yet elite breath-hold divers are able to tolerate marked reductions in blood oxygenation that only sometimes results in loss of consciousness (syncope). The mechanisms allowing such tolerance to hypoxemic extremes may serve as a useful model for the study of cerebrovascular regulation during physiological duress often observed in trauma and disease. This is especially true given that the study of regional brain perfusion during cardiorespiratory challenges, exercise, and in pathology has only begun in the past several years. Thus, the study of regional cerebrovascular regulation and its relation to the circulatory and ventilatory in healthy, trained breath-hold divers will yield new insight into the cerebrovascular function and systems integration in humans. Moreover, elucidation of these mechanistic relationships is paramount to our comprehension of myriad pathologies associated with arterial hypoxemia and/or elevations in blood viscosity or hemoglobin levels.]]></summary_en></project><project>
<id>3469</id><title_hr><![CDATA[Arheologija jadranske brodogradnje i plovidbe]]></title_hr><title_en><![CDATA[Archaeology of Adriatic Shipbuilding and Seafaring]]></title_en><user_id>5521</user_id><user_firstLast_name>Irena Radić Rossi</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-8211</code><acronim><![CDATA[AdriaS]]></acronim><duration>01.06.2015 - 31.05.2019</duration><status>Završio</status><financ_value>79.633,69 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Arheologija, Filozofija, Povijest, </scie_field_hr><scie_field_en>Archeology, Philosophy, History, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zadru]]></institution_hr><institution_en><![CDATA[University of Zadar]]></institution_en><team_members_id>3152, 5919, 5995, 5955, 2704, 6254, 6111, 18977, 17691, 6346, 6426, </team_members_id><team_members_names><![CDATA[Luka Boršić, Jose Casaban, Mariangela Nicolardi, Suzana Čule, Danijel Dzino, Smiljko Rudan, Mate Parica, Katarina Batur, David Ruff, Giulia Boetto, Antonio Vasilijević, ]]></team_members_names><keywords_hr><![CDATA[arheologija broda, brodogradnja, plovidba, Jadransko more, 3D modeliranje, podvodna robotika, povijest tehnologije]]></keywords_hr><keywords_en><![CDATA[nautical archaeology, shipbuilding, seafaring, Adriatic Sea, 3D modellin, underwater robotics, history of technology]]></keywords_en><summary_hr><![CDATA[Osnovni cilj projekta je potencirati sustavno interdisciplinarno proučavanje i interpretaciju arheoloških i povijesnih svjedočanstava o istočnojadranskoj brodogradnji i plovidbi. Bogata jadranska pomorska povijest, promatrana sa stanovišta tehnološkog razvoja drvene brodogradnje i plovidbe kroz vrijeme,  nije se donedavno sustavno proučavala zbog nedostatka odgovarajućih sredstava i solidne metodološke osnove. Projekt uzima u obzir kognitivne i praktične sljedove tehnološkog razvoja brodogradnje i plovidbe, proučavajući međusobne odnose tehnologije s jedne, te političkog, ekonomskog i kulturno-povijesnog konteksta s druge strane. Usredotočen je na problematiku iz svih vremenskih razdoblja ljudske prošlosti (prapovijest, antika, srednji vijek i rani novi vijek) putem aktivnog terenskog rada, arhivskog istraživanja i eksperimentiranja u području virtualne stvarnosti. Počevši od problematike ilirskih lemba i liburnskih liburna, do složene problematike velikih kasnorenesansnih trgovačkih brodova, on pruža sveobuhvatan pregled postignuća dosegnutih u prošlosti, te u hrvatsku znanost uvodi sustavan metodološki pristup proučavanju brodskih konstrukcija. Oslanjajući se na stanje istraživanja u području arheologije broda i pomorske povijesti na svjetskoj razini, projekt ima za cilj uvesti najsuvremenije metode proučavanja starih brodova, njihove opreme i tereta. On potiče inovativan interdisciplinarni pristup u procesu istraživanja, dokumentiranja i interpretacije najznačajnijih izravnih materjalnih svjedočanstava o istočnojadranskoj pomorskoj povijesti, promovirajući međunarodnu suradnju i umrežavanje među mladim znanstvenicima. Takav koncept stvorit će velik potencijal za čitavu zajednicu i potaknuti širi interes javnosti, naročito putem promidžbe projekta u javnim medijima i korištenja generiranog znanja u hrvatskoj turističkoj promociji. ]]></summary_hr><summary_en><![CDATA[The aim of the project is to enhance systematic interdisciplinary study and interpretation of the archaeological and historical record of shipbuilding and seafaring in the Eastern Adriatic. Its rich maritime history, seen through the technological development of wooden shipbuilding and seafaring and the dynamics that affected them over time, has not been systematically researched until recently, due to the lack of appropriate resources and the absence of a sound methodological basis. The project considers the cognitive and practical sequences of the technological development of shipbuilding and seafaring, studying the relationship between technology on one hand and the political, economic and cultural/historical context on the other. It focuses on issues from all periods of the human past (Prehistory, Classical Antiquity, Middle Ages and Early Modern period) through active fieldwork, archival research and virtual reality experimentation. From the problematic histories of the Illyrian lemboi and Liburnian liburnae, to the complex issues of the large late Renaissance merchantmen, it provides a comprehensive overview of the past achievements, and introduces into Croatian research the systematic methodological approach to the study of the ships’ hulls. Taking into consideration global state-of-the-art practices in the fields of nautical archaeology and maritime history, the project aims to introduce cutting edge methodologies of study of ancient ships, their equipment and cargoes. It will foster an innovative interdisciplinary approach in the process of research, recording and interpretation of the most significant direct material evidence of the Eastern Adriatic maritime past, while promoting international collaboration and networking among young researchers. Such concept will have great potential for community outreach and wider public interest, especially through promoting project in public media as well as using new knowledge in Croatian touristic promotion.]]></summary_en></project><project>
<id>3471</id><title_hr><![CDATA[Matrične faktorizacije i blok dijagonalizacijski algoritmi]]></title_hr><title_en><![CDATA[Matrix Factorizations and Block Diagonalization Algorithms]]></title_en><user_id>8764</user_id><user_firstLast_name>Vjeran Hari</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-3670</code><acronim><![CDATA[MFBDA]]></acronim><duration>01.05.2015 - 30.04.2019</duration><status>Završio</status><financ_value>76.266,51 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>13190, 13175, 13174, 13186, 13170, 13177, 18973, </team_members_id><team_members_names><![CDATA[Saša Singer, Erna Begović, Neven Krajina, Josip Matejaš, Vedran Novaković, Sanja Singer, Saša Stanko, ]]></team_members_names><keywords_hr><![CDATA[Matrice, matrične faktorizacije, blok algoritmi,  software, efikasnost, točnost, konvergencija]]></keywords_hr><keywords_en><![CDATA[Matrices, matrix factorizations, block algorithms, software, efficiency, accuracy, convergence]]></keywords_en><summary_hr><![CDATA[Matrične faktorizacije čine osnovni alat za rješavanje cijelog niza problema iz znanosti, inženjerstva i privrednih djelatnosti. Iako za navedene probleme postoje mnogi algoritmi i razvijena teorija, još uvijek postoji niz neriješenih problema. Cilj ovog projekta je proučavanje i poboljšavanje postojećih te otkrivanje novih algoritama Jacobijevog tipa za obični i generalizirani matrični problem svojstvenih i singularnih vrijednosti, kao i realne Schurove dekompozicije. Kao pomoćne algoritme razvit ćemo visoko točne algoritme za (običnu i hiperbolnu) singularnu dekompoziciju i za kosinus-sinus faktorizaciju ortogonalnih i J-ortogonalnih matrica. Budući da ortogonalne i J-ortogonalne matrice pripadaju klasi ortosimetričnih matrica, radit ćemo na razvoju algoritama i teorije za takve matrice sa specijalnom strukturom.Suvremeni matrični algoritmi moraju biti efikasni (što se postiže blok organizacijom algoritma, uz korištenje BLAS3 potprograma), robusni, stabilni i prilagodljivi za upotrebu na najnovijim računalnim resursima (CPU i GPU paralelizacija). Budući da mnoge algoritme dijagonalizacijskog tipa krasi relativna točnost i inherentni paralelizam, oni su idealni izbor za spomenute matrične probleme. Jedan od ciljeva ovog projekta je razvoj novih sekvencijalnih i paralelnih blok algoritama, jer oni na prirodni način generaliziraju i poboljšavaju postojeće algoritme. Za takve nove algoritme testirat će se njihova efikasnost, dokazivati globalna i asimptotička konvergencija te ocjenjivati njihova relativna točnost.Uspjeh projekta garantira sastav istraživača, jer su okupljeni dokazani stručnjaci iz teorije matrica i matričnih algoritama, kao i iz znanstvenog računanja, te nekoliko doktoranada koji su već pokazali snažan interes za matričnu teoriju i praksu. Kao rezultat rada na projektu očekujemo više od 10 znanstvenih radova u vrhunskim svjetskim časopisima i još 5-6 radova u časopisima koje referira SCIE lista. Razvit će se i testirati up-to-date software za spomenute algoritme.]]></summary_hr><summary_en><![CDATA[Matrix factorizations are the main tool for solving a wide variety of problems from science, engineering and economic activities. Although there are many algorithms that solve these problems and the theory is well developed, many unanswered questions still remain and so major improvements are possible. The aim of this project is to study and improve the existing and to develop new Jacobi-type algorithms for standard and generalized eigenvalue and singular value problems and real Schur decomposition. As ancillary algorithms a highly accurate algorithms for the standard and hyperbolic singular value decompositions and cosine-sine factorizations of orthogonal and J-orthogonal matrices will be developed. The last two belong to the class of orthosymmetric matrices and we intend to study structured matrices in this class and work on the efficient algorithm development.Modern numerical algorithms must be efficient, robust, stable and adaptable for use on the latest computing resources (CPU and GPU parallel processing). Since many of the standard diagonalization algorithms are adorned with high relative accuracy and inherent parallelism, one of the goals of this project is the development of new sequential and parallel block algorithms. Theoretically, their global and maybe the quadratic asymptotic convergence will be proved and high relative accuracy estimated.The success of the project is guaranteed by the selection of the researchers in the team. The team is comprised of experts with a proven track record in the theory of matrices and matrix (especially Jacobi-type) algorithms, together with experts in scientific computing and also several doctoral students who have already shown a strong interest in matrix theory and applications. As output of the project, it is expected that more than 10 papers will be published in leading scientific journals and several (5-6) in journals on the SCIE list, the complementary software will be developed and the algorithms implemented.]]></summary_en></project><project>
<id>3472</id><title_hr><![CDATA[TERAPIJSKI POTENCIJAL ORALNE GALAKTOZE U EKSPERIMENTALNOJ ALZHEIMEROVOJ BOLESTI]]></title_hr><title_en><![CDATA[THERAPEUTIC POTENTIAL OF ORAL GALACTOSE IN EXPERIMENTAL ALZHEIMER&#39;S DISEASE]]></title_en><user_id>1198</user_id><user_firstLast_name>Melita Šalković-Petrišić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-4639</code><acronim><![CDATA[GALAD]]></acronim><duration>15.09.2015 - 14.09.2018</duration><status>Završio</status><financ_value>99.542,11 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>1191, 3079, 4375, 3239, </team_members_id><team_members_names><![CDATA[Ana Knezović, Jelena  Osmanović Barilar, Andrija Lončar, Peter Riederer, ]]></team_members_names><keywords_hr><![CDATA[oralna galaktoza, streptozotocin, transgenični Tg2576 miševi, Alzheimerova bolest, glukagonu sličan peptid-1]]></keywords_hr><keywords_en><![CDATA[oral galactose, streptozotocin, transgenic Tg2576 mice, Alzheimer&#39;s disease, glucagone-like peptide-1]]></keywords_en><summary_hr><![CDATA[Cilj istraživanje je ispitati novi terapijski pristup Alzheimerovoj bolesti (AB), kao najčešćem obliku demencije. Porastom dokaza o inzulinskoj rezistenciji u mozgu (IRM) i cerebralnom metaboličkom poremećaju kao medijatorima sporadične AB (sAB), normaliziranje inzulinske signalizacije i posljedičnih poremećaja u mozgu postali su novi ciljevi u liječenja AB. Poseban doprinos istraživanja je karakterizacija terapijskog potencijala oralno primijenjene galaktoze u životinjskim modelima koji oponašaju sAB i familijarnu AB. Model za sAB su štakori s intracerebroventrikularnom primjenom streptozotocina (STZ-icv model) koja inducira nastajanje IRM i vremenom pojavu mnogih sAB-u sličnih obilježja. Model za familijarnu AB su transgenični Tg2576 miševi koji vremenom pokazuju neke od znakova IRM. Galaktoza je alternativni izvor energije; ulazi u stanice inzulin-neovisnim nosačem za glukozu GLUT3 i metabolizira se u glukozu. Nedavni rad glavnog ispitivača pokazao je da oralna galaktoza sprečava nastajanje kognitivnih deficita u štakorskom STZ-icv modelu. Ovo će istraživanja ispitati sprečava li ih u Tg2576 miševa te ublažava li već nastale kognitivne deficite u oba modela. Inovativni aspekt projekta je u rasvjetljavanju učinaka posredovanih oralnom galaktozom; poboljšanja cerebralnog unosa glukoze i stimulacije sekrecije glukagonu-sličnog peptida-1 (GLP-1) te njihove korelacije s kognitivnim poboljšanjem. Za utvrđivanje učinka 2-mjesečne primjene oralne galaktoze na poremećaje pamćenja koristit će se Morris Water Maze i Passive Avoidance testovi, radio-obilježenim ligandom pratit će se metabolizam glukoze u mozgu, dok će se Western blot analizom, imunohistokemijom i enzimskim imunoadsorpcijskim testom odrediti razina GLUT3/GLUT4 i inzulin-razgrađujućeg enzima, tau i amiloidna patologija u mozgu te količina galaktoze, inzulina i GLP-1 u plazmi i likvoru. Rezultati projekta generirat će nove spoznaje i omogućiti značajan uvid u novi, na nutrijentu temeljeni pristup liječenju AB.]]></summary_hr><summary_en><![CDATA[This project aims to explore a novel therapeutic strategy in Alzheimer’s disease (AD), the most common form of dementia. Owing to growing evidence of brain insulin resistance (BIR) and cerebral metabolic dysfunction being the mediators of sporadic AD (sAD), restoring of brain insulin signalling and downstream defects has recently become a new target in AD treatment research. Unique contribution of this proposal is in characterization of the therapeutic potential of oral galactose in animal models which mimic sAD and familial AD. The former is generated by streptozotocin-intracerebroventricular application (STZ-icv rat) which induces BIR and eventually develops many of sAD-like features, and the latter is transgenic Tg2576 mice which eventually show some signs of BIR. Galactose is alternative source of energy; it enters the cell via insulin-independent glucose transporter GLUT3 and is metabolized to glucose. PI’s recent publication indicates that oral galactose prevents development of cognitive deficits in STZ-icv rat model. This research will explore if it can prevent them in Tg2576 mice and ameliorate already developed cognitive deficits in both Tg2576 mice and STZ-icv rats. Innovative aspect of the proposal is elucidation of oral galactose-mediated improvement in cerebral glucose uptake and stimulation of glucagone-like peptide-1 (GLP-1) secretion, and their correlation to cognitive improvement in both models. Morris Water Maze and Passive Avoidance tests, radio-tracing of brain glucose metabolism, Western blot analysis, Enzyme-Linked Immunosorbent Assays and immunohistochemistry will be used to detect effects of 2-month oral galactose treatment on memory loss, GLUT3/GLUT4 and insulin degrading enzyme levels, tau and amyloid-ß pathology in the brain, and galactose, insulin and GLP-1 levels in blood/cerebrospinal fluid. Project results will gain new knowledge and provide significant insights into a novel nutrient-related therapeutic strategy in AD treatment.]]></summary_en></project><project>
<id>3473</id><title_hr><![CDATA[Holografija i interferometrija u uvjetima niske razine svjetlosti]]></title_hr><title_en><![CDATA[Holography and interferometry under weak illumination]]></title_en><user_id>5159</user_id><user_firstLast_name>Nazif Demoli</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-7515</code><acronim><![CDATA[HI-WI]]></acronim><duration>01.05.2015 - 31.05.2019</duration><status>Završio</status><financ_value>128.342,96 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut za fiziku]]></institution_hr><institution_en><![CDATA[Institute of Physics in Zagreb]]></institution_en><team_members_id>4857, 5697, 5141, 1037, 6611, 5148, 5293, </team_members_id><team_members_names><![CDATA[Hrvoje Skenderović, Mario Stipčević, Mladen Pavičić, Marin Karuza, Ognjen Milat, JADRANKO GLADIĆ, Davorin Lovrić, ]]></team_members_names><keywords_hr><![CDATA[holografija, digitalna holografija, interferometrija, numerički hologrami, brojanje fotona, kvantna kontekstualnost]]></keywords_hr><keywords_en><![CDATA[holography, digital holography, interferometry, numerical holograms, photon counting, quantum contextuality]]></keywords_en><summary_hr><![CDATA[Primarni interes ovog projekta je unaprijediti korištenje sustava i metoda temeljenih na digitalnoj holografiji i interferometriji u uvjetima niske razine svjetlosti, kao nastavak nedavnih dostignuća (Demoli i ostali, Opt. Lett. 39, 5010, 2014). U takvim uvjetima, standardni CCD zapisi digitalnih holograma pate od nedostatka informacija, jer su ili zasjenjeni šumom ili izravnati dubinom bit pretvorbe. Pokazali smo da se originalna informacija može efikasno sačuvati korištenjem detektora pojedinačnih fotona (PCD) umjesto CCD senzora i velikog dinamičkog raspona koji posjeduje PCD. Motivirani smo proširiti prethodno istraživanje na ostale holografske i interferometrijske tehnike kao i na kontekstualne eksperimente i interferometriju visoke osjetljivosti. Kao rezultat ovog projekta, bit će također razvijeni specijalizirani detektori pojedinačnih fotona te metoda direktnog laserskog upisivanja holograma.Glavni zadaci projekta su:(i) Istraživanje uloge eksperimentalnih parametara za snimanje vremenski usrednjenih i impulsnih digitalnih holograma u uvjetima niske razine svjetlosti. Očekivani rezultati su: pronalaženje optimalnog raspona glavnih parametara snimanja (omjer snopova, vrijeme ekspozicije, SNR, kontrast) i eksperimentalnih ograničenja zbog sprege različitih frekvencija (titranje površine, laserski puls, brzina PCD-a). (ii) Implementiranje kontekstualnih eksperimenata pomoću polarizacije i orbitalnog angularnog momenta fotona. Očekivani rezultat je demonstrirati kvantnu kontekstualnost u četvero-dimenzionalnom Hilbertovom prostoru na novi način koji se razlikuje od dosadašnjih.(iii) Istraživanje kvantnog efekta fotona u Fabry-Perot šupljini pomoću interferometrije visoke osjetljivosti. Očekivani rezultat je demonstrirati da samo kvantna teorija može objasniti raspodjelu događaja unutar zadanog vremenskog prozora.(iv) Razvoj specijaliziranih detektora brojanja pojedinačnih fotona i tehnike direktnog upisivanja holograma.]]></summary_hr><summary_en><![CDATA[The primary interest of this project is to advance the use of digital holography and interferometry based systems and techniques under the conditions of weak illumination, as a continuation of recent achievements (Demoli et al., Opt. Lett. 39, 5010, 2014). In such conditions, the standard CCD recordings of digital holograms suffer from the lack of information, since they are either obscured by noise or flattened by the bit depth conversion. We have shown that by using a photon counting detector (PCD) instead of a CCD sensor and by employing high dynamic range of the PCD, the original information can be efficiently preserved. We are motivated to extend the previous research to other holography and interferometry techniques as well as to perform contextual experiments and experiments in high-sensitivity interferometry. As a result of this project, the specialized photon counting detectors and direct laser hologram writing technique will be also developed.Main tasks of the project include:(i) Investigation of the role of the experimental parameters for recording the time-averaged and pulsed digital holograms under weak illumination. Expected results are: finding the optimum range of main recording parameters (beam ratio, exposure time, SNR, contrast) and experimental limitations due to coupling of various frequencies (surface vibrations, laser pulse, repetition rate of PCD).(ii) Implementation of contextual experiments by means of photon polarization and orbital angular momentum. Expected result is to demonstrate quantum contextuality in a four-dimensional Hilbert space in a new way different from previous.(iii) Investigation of a quantum effect of a photon buildup in a Fabry-Perot cavity by employing high-sensitivity interferometry. Expected result is to demonstrate that only quantum theory can explain the distribution of events within a given time window.(iv) Developments of the specialized photon counting detectors and direct laser writing of holograms technique.]]></summary_en></project><project>
<id>3476</id><title_hr><![CDATA[Utjecaj podrijetla i izolacije na ADME gene: primjer romske populacije]]></title_hr><title_en><![CDATA[Impact of ancestry and isolation on ADME genes - the Roma example]]></title_en><user_id>12348</user_id><user_firstLast_name>Marijana Peričić Salihović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-4454</code><acronim><![CDATA[ADMEROMA]]></acronim><duration>01.09.2015 - 31.12.2019</duration><status>Završio</status><financ_value>127.254,63 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut za antropologiju]]></institution_hr><institution_en><![CDATA[Institute for Anthropological Research]]></institution_en><team_members_id>12595, 12594, 12597, 12895, 12592, 25214, </team_members_id><team_members_names><![CDATA[Branka Janićijević, Nina Smolej Narančić, TATJANA ŠKARIĆ-JURIĆ, Matea Zajc Petranović, Željka Tomas, Anita Stojanović Marković, ]]></team_members_names><keywords_hr><![CDATA[ADME geni, Romi, izolacija, populacijska struktura, polimorfizmi, CYP2D6, CYP1A2]]></keywords_hr><keywords_en><![CDATA[ADME genes, Roma, isolation, population structure, polymorphisms, CYP2D6, CYP1A2]]></keywords_en><summary_hr><![CDATA[Genomska raznolikost suvremenih populacija odražava demografske i evolucijske događaje u prošlosti što se posebno očituje u izoliranim populacijama. Romi su primjer populacije utemeljitelja u kojoj je višestoljetna sociokulturna izolacija ostavila tragove u zalihi gena, vidljive u znatnoj genskoj različitosti Roma od drugih populacija. ADME geni, odgovorni za apsorpciju, distribuciju, metabolizam i izlučivanje lijekova, ubrajaju se u one koji pokazuju značajnu varijabilnost među populacijama. Unatoč dokazanoj funkcionalnoj ulozi, znanje o njihovoj distribuciji u izoliranim populacijama vrlo je ograničeno. Stoga u ovom projektu namjeravamo istražiti polimorfizme ADME gena analizom temeljnih ADME biljega i gena CYP2D6 i CYP1A2 na uzorku od 300 osoba, pripadnika triju različitih romskih skupina iz Hrvatske. Glavni je cilj projekta odrediti varijacije ADME gena u romskoj populaciji kako bi se utvrdio utjecaj višestrukih učinaka utemeljitelja i uskog grla, izolacije i endogamije na ovu važnu skupinu gena. Taj cilj bit će postignut provedbom analize populacijske strukture, procjenom starosti mutacija i funkcionalnom analizom in silico. Očekujemo da ćemo pronaći specifične razdiobe alela istraživanih lokusa unutar ADME gena, kao i genske osobitosti koje odražavaju indijsko podrijetlo Roma te pokazatelje koji upućuju na tok gena između romske i drugih populacija s kojima su dolazili u doticaj tijekom migracija iz Indije u Europu. Novoutvrđeni ADME genski profil svojstven romskoj populaciji bit će važan za svakodnevnu medicinsku praksu pri modulaciji farmakoterapije. Također, dobiveni će rezultati doprinijeti farmakogenetici upotpunjavanjem slike o varijacijama ADME gena kod Roma te omogućiti primjenu tih spoznaja u razvoju farmakogenetičkih testova specifičnih za ovu manjinsku populaciju koja u svijetu broji preko 15 milijuna ljudi. Očekujemo da će rezultati istaknuti populacijsku specifičnost ADME gena i potaknuti provedbu takvih istraživanja u ostalim izolatima svijeta.]]></summary_hr><summary_en><![CDATA[Contemporary populations’ genomic diversity reflects past demographic and evolutionary events, pronounced in isolated populations. The Roma is an example of a founder population with centuries long sociocultural isolation which left traces in their gene pool which shows considerable differences compared with other populations. The genes that significantly differentiate among populations are those responsible for absorption, distribution, metabolism and excretion of drugs (ADME genes). The knowledge on their distribution in isolated populations is limited. Therefore, in this application we propose to study ADME genes&#39; polymorphisms through the analysis of ADME core markers and CYP2D6 and CYP1A2 genes in 300 DNA samples obtained from three Roma groups in Croatia. The general objective of this project is to determine the variation of ADME genes in Roma population, to assess the extent to which the population history which includes multiple bottleneck/founder events, isolation and endogamy impacted this important gene family. This will be achieved through population structure analysis, the assessment of the age of mutations and in silico functional analysis. We expect to find specific allele distributions of the investigated loci within the ADME genes, landmarks that reflect the Indian origin of the Roma and the signals of admixture with the populations they came in close contact with in the past during their migration from India to Europe. Our assessment of Roma’ unique genetic profile will contribute to the medical practice through the modulation of pharmacotherapy in Roma population. It will also significantly contribute to the field of pharmacogenetics in terms of information on the genetic variation in Roma, essential for the development of pharmacogenetic tests specific for this minority population estimated to around 15 million people. The results promise to highlight the population uniqueness in ADME genes and encourage similar research in the world’s isolates.]]></summary_en></project><project>
<id>3478</id><title_hr><![CDATA[Klostridijski neurotoksini i mozak]]></title_hr><title_en><![CDATA[Clostridial Neurotoxins and Brain]]></title_en><user_id>3574</user_id><user_firstLast_name>Zdravko Lackovic</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-4503</code><acronim><![CDATA[BrainTox]]></acronim><duration>20.10.2015 - 19.10.2017</duration><status>Završio</status><financ_value>66.361,40 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, Clinical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>4119, 6881, 4059, 6200, 13244, 3885, 3901, 4022, 13617, </team_members_id><team_members_names><![CDATA[Maja Relja, Claudia Sommer, Boris Filipović, Zsuzsanna Helyes, Matteo Caleo, Lidija Bach-Rojecky, Višnja Drinovac, Ivica Matak, Nataša  Klepac , ]]></team_members_names><keywords_hr><![CDATA[botulinum toksin A, tetanus toksin, bol, antinociceptivno djelovanje, motorni sustav, ne-motorni središnji učinci]]></keywords_hr><keywords_en><![CDATA[botulinum toxin A, tetanus toxin, pain, antinocieptive activity, motor system, non-motor central effects]]></keywords_en><summary_hr><![CDATA[Botulinum toksini (BTX) i tetanus toksin (TTX) su najvažniji klostridijski toksini, i među najtoksičnijim tvarima u prirodi. Jedan gram BTX tipa A (BTX-A) može ubiti više od milijun ljudi inhalacijom. Istovremeno, BTX-A se često koristi u terapijske svrhe, a kozmetička primjena je najraširenija (Botox).Danas se njegova primjena u određenih vrsta boli povećava. Dugotrajno djelovanje I sigurnost su od naročite kliničke važnosti. Do nedavno se vjerovalo da je osnovni mehanizam antinociceptivnog djelovanja BTX-A vezan uz periferne živčane okončine, a posredovan cijepanjem SNAP-25, proteina uključenog u lučenje neurotransmitora.Rezultati iz našeg laboratorija su prvi pokazali da BTX-A retrogradno putuje s periferije u  središnji živčani sustav kroz senzorne neurone, te središnje mjesto djelovanja na bol. Međutim, točan mehanizam je nerazjašnjen. Stoga su glavni ciljevi projekta istraživanje: I. Utjecaja BTX-A na opioidne receptore i opioidne peptide, te uključenost glutamatnih receptora; uloga spinalnih i supraspinalnih glija stanica u antinociceptivnom djelovanju BTX-A;II. Mehanizma središnjeg djelovanja BTX-A na bilateralnu bol;III. Povezanosti kapsaicin-osjetljivih neurona i antinociceptivnog djelovanja BTX-A;IV. Učinka BTX-A na trigeminovaskularni sustav i peptid srodan genu za kalcitonin, kao mogući mehanizam njegovog djelovanja na migrenu;V. Središnjih učinaka BTX-A na motorni sustav; VI. Usporedbe BTX-A i TTX temeljm pretpostavke da injiciranje malih količina TTX u senzorne živce i ganglije može također utjecati na bol.VII. Istovremeno s eksperimentalnim istraživanjima, promatrat će se učinak BTX-A na različite ne-motorne funkcije u pacijenata s migrenom ili distonijom. To čini naš projektni prijedlog translacijskim istraživanjem. Predložena istraživanje mogu objasniti učinke BTX-A na kroničnu bol, migrenu i hiperkinetske poremećaje pokreta što može značajno unaprijediti njegovu kliničku primjenu.]]></summary_hr><summary_en><![CDATA[Botulinum toxins (BTX) and tetanus toxin (TTX) are the most important clostridial neurotoxins and one of the most toxic substances in nature. One gram of BTX type A (BTX-A) could kill more than one million people via inhalational route. At the same it is often used for therapeutic, especially cosmetic purposes (Botox).Today, BTX-A use in certain types of pain is increasing. Long-term effectiveness and safety are of a special clinical value. Until recently it was believed that the primary mechanism of BTX-A antinociceptive action is at peripheral nerve endings, mediated by prevention of neurotransmitter release, caused by cleavage of SNAP-25, protein required for exocytosys. We revealed for the first time the BTX-A retrograde transport from the periphery to the CNS in sensory nerves, and the central site of action. However, the exact mechanism is yet unresolved. Thus, main goals of our research are to study: I. BTX-A influence on opioid receptors and opioid peptides and involvement of glutamate receptors; the role of spinal and supraspinal glia in antinociceptive action of BTX-A;II. The mechanism of BTX-A central action on bilateral pain;III. The association of capsaicin-sensitive neurons and BTX-A antinociceptive activity; IV. The effect of BTX-A on trigeminovascular system and calcitonin gene-related peptide, as a possible mechanism of its antimigraine action;V. The potential central effects of BTX-A in motor system;VI. Comparison of BTX-A to TTX, based on assumption that application of small amounts of TTX into sensory nerves and ganglia could have the effect on pain.VII. In parallel, the effect of BTX-A on various non-motor functions in migraine or dystonic patients will be studied. This makes our research also a translational research.Proposed project could lead to the explanation of BTX-A mechanisms of action in chronic pain, migraine, and hyperkinetic movement disorders, which would make an important contribution to possible refinement of its clinical use. ]]></summary_en></project><project>
<id>3479</id><title_hr><![CDATA[PRIMJENA CIJEVNIH PROPUSTA ZA POBOLJŠANJE KVALITETE MORA U LUKAMA/MARINAMA]]></title_hr><title_en><![CDATA[IMPLEMENTATION OF THE FLUSHING CULVERTS FOR THE IMPROVEMENT OF THE SEA QUALITY IN HARBOURS/MARINAS (EKO MARINA)]]></title_en><user_id>4885</user_id><user_firstLast_name>Dalibor Carević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2014-09</proposal_call><code>UIP-2014-09-6774</code><acronim><![CDATA[EKO MARINA]]></acronim><duration>01.10.2015 - 30.09.2018</duration><status>Završio</status><financ_value>78.073,82 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Građevinarstvo, </scie_field_hr><scie_field_en>Civil engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Građevinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Civil Engineering]]></institution_en><team_members_id>6656, 6250, 3007, 4827, 13609, 13662, 18927, 18928, 21304, </team_members_id><team_members_names><![CDATA[GORAN  LONČAR, Gordon Gilja, Gordana Beg Paklar, Hrvoje MOSTEČAK, Vasiliki Tsoukala, Predrag Vukadin, Ivana Bartolić, Igor Ružić, Ratko Ramuščak, ]]></team_members_names><keywords_hr><![CDATA[cijevni propusti, izmjena mora, vrijeme zadržavanja, cirkulacija u luci, eko marina]]></keywords_hr><keywords_en><![CDATA[flushing culverts, residence time, flushing time, sea exchange, eko marina]]></keywords_en><summary_hr><![CDATA[Ovaj projekt donosi zaključke o mjerama koje trebaju biti primijenjene u svrhu osiguranja dovoljne izmjene vode u budućim lukama upotrebom cijevnih propusta. Ugradnja cijevnih propusta u konstrukciju lukobrana je najjeftinija metoda, između ostalih. Svrha cijevnih propusta je da omoguće izmjenu vode između otvorenog mora i mora zatvorenog u luci. Generalno postoji manjak znanja koji bi opisivao funkcioniranje cijevnih propusta kao instrumenta za izmjenjivanje vode. Slijedeća pitanja trebaju biti odgovorena kroz faze ovoga projekta: 1. FAZA I: Koja se veličina protoka ostvaruje u propustima pod djelovanjem vjetrovnih valova, i kolika je vrijednost transmitirane valne energije? Metodologija: Fizikalni model u laboratoriju (u valnom kanalu) sa modelom cijevnih propusta. 2. FAZA II: Funkcioniranje cijevnih propusta u realnim uvjetima (u stvarnoj luci), što znači, složeni uvjeti istovremenog djelovanja valova s vanjske strane luke zajedno sa plimnim oscilacijama i vjetrovnom cirkulacijom mora (koji je protok u propustima u takvim uvjetima?). Metodologija: Sveobuhvatna terenska mjerenja u marini Ičići (Opatija) u svrhu kalibracije 3D numeričkog modela. 3. FAZA III: Koliko pozija propusta u tijelu lukobrana doprinosi protoku u propustima? Metodologija: 3D numeričko modeliranje.Općenita svrha istraživanja je razotkriti funkcioniranje cijevnih propusta korištenjem laboratorijskih modela, terenskih istraživanja i numeričkog modeliranja. Rezultat istraživanja će biti inženjerske preporuke i jednostavni matematički modeli (jednadžbe, grafovi) koji će pomoći inženjerima u optimalnom projektiranju cijevnih propusta.]]></summary_hr><summary_en><![CDATA[This project provide conclusions on measures that need to be implemented in order to secure enough exchange of water mass in future harbors using flushing culverts (pipes). Installation of flushing culverts inside the breakwater structure is the most cost-effective method, among others. The purpose of culverts is to enable the exchange of the open sea water and the water contained within a protected maritime zone. There is a general lack in research that would provide an explanation on how pipe culverts actually work as a sea water exchange instrument. The next answers should be reached through phases of this project. 1. PHASE I: What is the amount of water discharge in culverts under the agency of surface wind waves, and what is the amount of wave energy transmission?. Methodology: Physical model in laboratory (wave channel) with flushing culverts model. 2. PHASE II: Functioning of flushing culverts in a realistic conditions (in real harbor), which means, the complex conditions of simultaneous actions of waves coming from outside a harbor along with tidal oscillations and wind driven circulation of sea (what is the water discharge in culverts in such conditions?). Methodology: Extensive field measurements in Ičići marina (Opatija) with purpose on calibration of 3D numerical model . 3. PHASE III: How much does positions of culverts in breakwater’s body contributes to the culverts discharge? Methodology: 3D numerical modelling. The overall purpose of the research is to discover flushing culverts functioning using laboratory models, field measurements and numerical modelling The result of the research would be engineering guides and simple mathematical models (equations, graphs) that would help engineers in optimal design of the flushing culverts. ]]></summary_en></project><project>
<id>3480</id><title_hr><![CDATA[Približavanje strategije i prakse nagrađivanja hrvatskih poduzeća europskoj praksi]]></title_hr><title_en><![CDATA[Closing the gap in compensation strategy and practice between Croatia and EU]]></title_en><user_id>12985</user_id><user_firstLast_name>Lovorka Galetić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-5600</code><acronim><![CDATA[CompCroEU]]></acronim><duration>15.09.2015 - 14.12.2018</duration><status>Završio</status><financ_value>37.777,75 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, </scie_field_hr><scie_field_en>Economy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Ekonomski fakultet u Zagrebu]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Economics and Business]]></institution_en><team_members_id>12588, 13589, 13596, 3081, </team_members_id><team_members_names><![CDATA[Ivana Načinović Braje, MAJA KLINDŽIĆ, Danica Bakotić, Ivana Šandrk Nukić, ]]></team_members_names><keywords_hr><![CDATA[kompenzacijski menadžment, strategija nagrađivanja, sustav nagrađivanja, plaća, beneficije, ]]></keywords_hr><keywords_en><![CDATA[compensation management, compensation strategy, reward system, pay, benefits, ]]></keywords_en><summary_hr><![CDATA[Kompenzacijski menadžment obuhvaća organizirani skup organizacijskih praksi koje su usmjerene na reguliranje odnosa između poslodavca i zaposlenika, na način da se zaposlenicima za uloženo vrijeme i trud osiguraju odgovarajuće materijalne i nematerijalne nagrade. Kompenzacije su ključni element u međusobnom odnosu poslodavca i zaposlenika.  Za mnoga poduzeća kompenzacije predstavljaju najveći pojedinačni operativni izdatak, te su istodobno prepoznate kao mehanizam za povećanje uspješnosti organizacije te održavanje konkurentnosti. Uslijed snažnog utjecaja kompenzacijskog menadžmenta na sveukupnu uspješnost organizacija, prepoznata je važnost proučavanja ove tematike među hrvatskim poduzećima. Štoviše, obzirom da hrvatska poduzeća odnedavno spadaju u sastavni dio većeg internog tržišta Europske Unije (EU) na kojem su zagarantirani mobilnost i sloboda kretanja, prepoznata je važnost konkurentnosti praksi kompenzacijskog menadžmenta primijenjenih u hrvatskim poduzećima u širem kontekstu EU. Istraživanje je usmjereno na komparativnu analizu strategija i praksi nagrađivanja primijenjenih u Hrvatskoj i zemljama EU, kako bi se dodatno produbilo znanje o ovom području, odnosno sve u cilju razvijanja strategija nagrađivanja koje će omogućiti hrvatskim poduzećima jačanje konkurentnosti i umanjiti odlazak zaposlenika na strana tržišta rada. Sinteza analize dostupnih spoznaja, kao i povedenog istraživanja, omogućila bi razvijanje skupa preporuka za hrvatska poduzeća kako primijeniti suvremene prakse u nagrađivanju u hrvatskom kontekstu. Također, temeljem svih prikupljenih rezultata osmislili bi se i provodili programi edukacije za specijaliste za kompenzacije. Komparativne studije s ovakvom tematikom su nepostojeće te bi stoga upravo ovo istraživanje predstavljalo dodatni iskorak u istraživanju promatranog područja. ]]></summary_hr><summary_en><![CDATA[Compensation management is an organized organizational practice that involves balancing the employer-employee relation by providing monetary and non-monetary benefits to employees for their time and effort. Compensation is a key element of the employment relationship and, in addition to being the single greatest operating cost for many organizations, it has been advocated as a tool for enhancing organizational performance and sustained competitiveness. Due to high impact of compensation management on overall firm performance, we recognized the need to research it in detail within Croatian companies. Furthermore, since Croatian companies constitute just a part of the larger European Union (EU) market in which mobility and free movement of persons is guaranteed we thus find that compensation management strategies and practices used by Croatian companies must be competitive within larger EU context. This research is aimed at making comparative research of Croatian and EU countries’ compensation strategies and practices in order to develop knowledge on the topic, all with the purpose of developing compensation strategies that would allow Croatian companies to increase their relative competitiveness and reduce excessive employee drain to foreign labour markets. Besides scientific dissemination, research findings would allow developing recommendations for Croatian companies how to use state-of-the art compensation practices applied to Croatian context and would be used as inputs in developing education programs for compensation specialists. Comparative studies exploring such gap and its implications are non-existent. This study should therefore represent an early and exploratory approach toward developing this field.]]></summary_en></project><project>
<id>3487</id><title_hr><![CDATA[Napredni sustavi bušenja u koštano-zglobnoj kirurgiji]]></title_hr><title_en><![CDATA[Advanced Drilling Systems in Bone and Joint Surgery]]></title_en><user_id>13622</user_id><user_firstLast_name>Toma  Udiljak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-9870</code><acronim><![CDATA[ADRISS]]></acronim><duration>15.09.2015 - 14.09.2018</duration><status>Završio</status><financ_value>75.585,64 eur</financ_value><scie_area_hr>Tehničke znanosti, Biomedicina i zdravstvo, </scie_area_hr><scie_area_en>Technological sciences, Biomedicine and health sciences, </scie_area_en><scie_field_hr>Strojarstvo, Elektrotehnika, Računarstvo, Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Mechnical engineering, Electrical engineering, Computer sciences, Clinical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>13485, 13549, 6544, 12778, 12930, 13147, 13484, 13591, 12708, 4841, 13645, </team_members_id><team_members_names><![CDATA[Dubravko Majetić, Damir Ciglar, Josip Kasać, Goran Augustin, Tomislav Bruketa, Tin Ehrenfreund, Nenad Ferdelji, Miho Klaić, Danko Brezak, Zoran Domitran, Tomislav Staroveški, ]]></team_members_names><keywords_hr><![CDATA[bušenje, koštano-zglobna kirurgija, termička osteonekroza, nadzor, upravljanje, protočno hlađenje, automatizirana obrada, računalna inteligencija]]></keywords_hr><keywords_en><![CDATA[Drilling, Bone and joint surgery, Thermal osteonecrosis, Monitoring, Control, Internally cooled tool, Automated machining, Computational intelligence]]></keywords_en><summary_hr><![CDATA[Današnji sustavi medicinskog bušenja s primjenom u koštano-zglobnoj kirurgiji relativno su niskog stupnja automatizacije bez mogućnosti nadzora obradnog procesa i/ili adaptivnog upravljanja parametrima obrade u cilju sprječavanja mehaničkih i termičkih oštećenja koštanog tkiva. S druge strane, na pojavu termičke osteonekroze značajno utječe i primjena medicinskih svrdla bez mogućnosti protočnog hlađenja. Pritom se hlađenje često obavlja zalijevanjem površine kosti i tijela svrdla izvan kosti tijekom obrade što ima vrlo ograničeni efekt uslijed odvojenih čestica koje sprječavaju kontakt rashladnog sredstva s oštricama svrdla i činjenice da kost ima relativno nisku toplinsku vodljivost. Stoga je u okviru ovog projekta predložen niz aktivnosti koje bi trebale rezultirati razvojem novih sustava s perspektivom implementacije u slijedećim generacijama ručnih bušilica. Njihove bi karakteristike trebale potencijalno omogućiti nadzor mehaničkih i toplinskih utjecaja na alat i kost primjenom različitih vrsta mjernih sustava i naprednih algoritama odlučivanja, eksploataciju protočno hlađenih svrdla visokog učinka hlađenja, automatizaciju posmičnog gibanja alata uz potencijalnu primjenu visokobrzinskih režima obrade, te primjenu naprednih adaptivnih upravljačkih algoritama u cilju ograničenja sila i temperature rezanja. Realizacija postavljenih ciljeva omogućila bi prelazak iz područja potpuno ručnog bušenja u polu-automatizirani pristup u kojem bi operater ručno određivao samo mjesto bušenja i smjer/kut alata s obzirom na kost dok bi se preostale aktivnosti procesa odvijale autonomno korištenjem upravljačkog sustava stroja.]]></summary_hr><summary_en><![CDATA[Modern medical drilling systems used in bone and joint surgery are characterized with relatively low level of automation, i.e., with no process monitoring and/or adaptive control characteristics, which would prevent mechanical and thermal bone damages. On the other hand, application of classic medical drills with no internal cooling capabilities significantly influence on the occurrence of thermal osteonecrosis. Cooling is usually performed by applying cooling fluid externally on the bone surface and the part of tool not in the bone during the drilling process. This approach has very limited effect on the temperature reduction because bone debris prevent contact of cooling fluid with tool cutting edges, and bone itself has very low thermal conductivity. Therefore, a group of activities have been proposed by this project focused on the development of new systems with the implementation perspective in the next generation of hand-held drilling machines. Their characteristics should potentially ensure on-line monitoring of the mechanical and thermal effects on the tool and bone using different types of sensors and advanced decision algorithms, exploitation of highly effective internally cooled medical drills, automated tool feed movement with potential implementation of high-speed drilling regimes, as well as the application of advanced adaptive control algorithms for cutting forces and drilling temperature limitation. Implementation of those features would ensure transition from completely hand-controlled drilling machines to semi-automatic systems, where only drilling location and desired tool direction/angle should be defined by the surgeon, while all other activities would be performed autonomously by the machine monitoring and control system.]]></summary_en></project><project>
<id>3489</id><title_hr><![CDATA[Razvoj numeričkih modela armirano-betonskih i kamenih zidanih konstrukcija izloženih potresnom opterećenju zasnovanih na diskretnim pukotinama]]></title_hr><title_en><![CDATA[Development of numerical models for reinforced-concrete and stone masonry structures under seismic loading based on discrete cracks]]></title_en><user_id>5683</user_id><user_firstLast_name>Željana Nikolić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-2319</code><acronim><![CDATA[SeismoNuMod]]></acronim><duration>01.09.2015 - 30.09.2019</duration><status>Završio</status><financ_value>119.769,06 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Građevinarstvo, Temeljne tehničke znanosti, </scie_field_hr><scie_field_en>Civil engineering, Basic engineering sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu Fakultet građevinarstva, arhitekture i geodezije]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Civil Engineering, Architecture and Geodesy]]></institution_en><team_members_id>13081, 5724, 5725, 12603, 13219, 12718, 13055, 13163, 13162, </team_members_id><team_members_names><![CDATA[Pavao Marović, Nikolina Živaljić, Hrvoje Smoljanović, Ivan Balić, Mijo Nikolić, Adnan Ibrahimbegovic, Lidija Krstevska, Mladen Glibić, Mladen Kustura, ]]></team_members_names><keywords_hr><![CDATA[Numeričko modeliranje,  Potresno djelovanje, AB konstrukcije, Kamene zidane konstrukcije, Diskretne pukotine]]></keywords_hr><keywords_en><![CDATA[Numerical modelling, Earthquake loading, RC structures, Stone masonry structures, Discrete cracks]]></keywords_en><summary_hr><![CDATA[Pojava pukotina je jedan od dominantnih uzroka nelinearnosti u krtim i kvazi-konstrukcijama koja dovodi do pojave lokaliziranog sloma i predstavlja ozbiljan izazov u numeričkom modeliranju. Proces nastanka pukotina započinje na mikrorazini, a progresivnim srastanjem stvaraju se makropukotine koje predstavljaju diskontinuitet u materijalu. Precizno modeliranje otvaranja i zatvaranja pukotina jedan je od ključnih čimbenika koji utječe na pouzdanost modela za analizu konstrukcija, posebno onih izloženih potresnom opterećenju. Sofisticirani numerički modeli temeljeni na metodi odgovora u vremenu i inkrementalnoj dinamičkoj analizi imaju značajnu ulogu u simulaciji ponašanja takvih konstrukcija prije i poslije sloma. U ovom projektu planira se razvoj dvaju nelinearnih modela za inkrementalnu dinamičku analizu konstrukcija zasnovanih na diskretnim pukotinama s različitim pristupima u rješavanju ovog problema. Jedan će biti novi 3D model za potresno opterećene armirano-betonske i kamene zidane konstrukcije ojačane trnovima i klamfama, zasnovan na metodi kombiniranih konačno-diskretnih elemenata kod koje pukotine nastaju u kontaktnim elementima smještenima duž rubova konačnih elemenata. Model će omogućiti raspucavanje, dinamičku interakciju razdvojenih elementa i praćenje ponašanja konstrukcije prije i nakon sloma. Drugi model će biti zasnovan na metodi konačnih elementa s ugrađenim diskontinuitetom i ugrađenom armaturom koja omogućuje nastanak pukotina neovisno o mreži konačnih elemenata i primijenit će se na armirano-betonske konstrukcije. Validacija razvijenih modela će se provesti usporedbom s dostupnim rezultatima eksperimentalnih istraživanja, dok se u svrhu validacije modela za kamene zidane konstrukcije planiraju provesti vlastiti eksperimenti na potresnoj platformi. Na kraju će se provesti usporedne analize ponašanja konstrukcija s oba modela.]]></summary_hr><summary_en><![CDATA[Crack opening is one of the dominant causes of nonlinearity in brittle and quasi-brittle structures which leads to localized failure and stands out as a serious challenge in numerical modelling. The process of crack initiation starts at a micro-scale, and with progressive growth, micro-cracks coalesce into macro-cracks representing discontinuities in the material. Therefore, a realistic modelling of crack initiation and propagation is one of the key factors that affect the reliability of the model for analysing the structures, especially those subjected to earthquakes. Sophisticated numerical models based on time dependent and incremental dynamic analysis can play an important role in simulating the behaviour of such structures before and after collapse. This project aims to develop two nonlinear numerical models for incremental dynamic analysis of structures based on the model of discrete cracks. The first one will be a novel 3D model for reinforced concrete and stone masonry structures strengthened with clamps and bolts based on the combined finite discrete element method where the cracks are modelled through the contact elements implemented between finite elements. The model enables crack initiation and propagation, dynamic interaction of separate elements and monitoring of structural behaviour before and after the collapse. The second model will be based on the finite element method with embedded discontinuity and embedded reinforcement, which allows for crack initiation and propagation independent of finite element mesh and will be applied to reinforced concrete structures. The novel numerical models for reinforced concrete structures will be validated by available experimental research, while our own experiments are planned to be performed at shaking table for the validation of stone masonry structure model. Thereafter, the comparative analysis of the behaviour of real structures with both models will be conducted.]]></summary_en></project><project>
<id>3491</id><title_hr><![CDATA[Karakterizacija preuređivanja endosomalnih membrana tijekom rane faze infekcije mišjim citomegalovirusom koje vodi k formiranju kompleksa za stvaranje viriona]]></title_hr><title_en><![CDATA[Characterization of endosomal remodelling during the early phase of murine cytomegalovirus infection that leads to the development of the assembly complex]]></title_en><user_id>6604</user_id><user_firstLast_name>Pero Lučin</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-9564</code><acronim><![CDATA[AsCo]]></acronim><duration>01.09.2015 - 31.08.2019</duration><status>Završio</status><financ_value>105.731,77 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Medicine]]></institution_en><team_members_id>6883, 6891, 6187, 6963, 21237, 21236, </team_members_id><team_members_names><![CDATA[Hana  Mahmutefendić, Gordana Blagojević Zagorac, Kristina Grabušić, Ljerka Karleuša, Marina Marcelic, Silvija Lukanović Jurić, ]]></team_members_names><keywords_hr><![CDATA[citomegalovirus, endosomi, preuređivanje endosoma, sklapanje viriona, fosfoinositidi]]></keywords_hr><keywords_en><![CDATA[Cytomegalovirus, endosomes, endosomal remodeling, virion assembly, phosphoinositides]]></keywords_en><summary_hr><![CDATA[Infekcija beta-herpesvirusima izaziva opsežnu reorganiziraju unutarstaničnih odjeljka u svrhu stvaranja okruženja za stvaranje virusa, poznatog kao kompleks za stvaranje virusa (AC, engl. assembly complex). Ova struktura razvija se postupno, počevši od najranijih stadija infekcije, i uključuje stupnjevitu reorganizaciju membranskih organela. Iako je sastav i organizacija AC relativno dobro karakterizirana tijekom infekcije humanim citomegalovirusom (CMV), dio događanja koji vodi razvoju AC-a je slabo poznat. Cilj ovoga projekta je karakterizirati procese koji prethode stvaranju AC-a u stanicama inficiranim mišjim CMV-om (MCMV). MCMV započinje remodeliranje endosomalnog sustava vrlo rano tijekom infekcije, što smo karakterizirali kao razvoj endosomalnog retencijskog odjeljka rane faze (EPERC). Postoji jaka indikacija da je upravo EPERC prethodnih AC-a. Općenito je prihvaćeno da je remodeliranje endosomalnog sustava posredovano malim GTPazama iz Rab i Arf obitelji te fosfoinozitidima.  U predloženom projektu cilj nam je razotkriti procese reorganizacije membranskih organela tijekom rane faze infekcije, koji dovode do stvaranja AC-a. U tu svrhu utvrditi ćemo ulogu malih ATPaza iz obitelji Rab i Arf te njihovih efektorskih proteina tijekom stvaranja EPERC. Naposljetku, karakterizirati ćemo membranske domene EPERC-a tijekom rane faze infekcije obzirom na sastav fosfoinositida. To će uključivati proučavanje endosomalnih efektorskih proteina koji se vezuju na fosfoinositide i glavnih endosomalnih enzima koji nadziru konverziju fosfoinositida i tako mijenjaju osobine membrana. Kako bismo postigli navedene ciljeve koristiti ćemo trostruko imunofluorescencijsko bojanje EPERC-a, fluorescentne boje stvorene genetičkim inženjeringom, utišavanje RNA i farmakološke inhibitore. Konačni ishod predloženog istraživanja biti će rekonstrukcija mehanizma razvoja EPERC-a i identifikacija staničnih proteina koji predstavljaju mjesto djelovanja MCMV-a tijekom rane faze infekcije.]]></summary_hr><summary_en><![CDATA[Beta-herpesviruses massively reorganize the intracellular compartments in order to create an environment for virion production, known as assembly complex (AC). This structure develops gradually from the earliest stages of infection and involves stepwise reorganization of membrane organelles. Although the final structure is relatively well characterized during human cytomegalovirus infection, the sequence of events that leads to the development of the AC is poorly understood. The goal of this project is to characterize processes proceeding to the formation of the AC in cells infected with murine CMV (MCMV). MCMV starts with remodeling of the endosomal system very early in the infection, which we characterized as development of the early-phase endosomal retention compartment (EPERC). There is strong indication that the EPERC is predecessor of AC. It is generally accepted that endosomal remodeling is driven by small GTPases from the Rab and Arf family and phosphoinositides (PI). In the proposed project, we plan to reveal sequence of membranous organelle reorganization events in the early phase of infection that presumably lead to the formation of the AC. With that purpose, we will determine the role of small GTPases of the Rab and Arf family and their effector proteins in membrane organelle perturbation events during the early phase of MCMV infection. Finally, we plan to characterize membrane domains of the EPERC during the entire early phase regarding PI content, which include the study of PI effectors and major enzymes that drive PI conversion and thereby change membrane identity. To achieve these goals, we will use triple immunofluorescence staining of EPERC, genetically engineered fluorescent probes, RNA silencing and pharmacological inhibitors. Outcome of the proposed research will be a reconstruction of the mechanism of development of the EPERC and identification of cellular proteins that are targeted by MCMV in the early phase of infection.]]></summary_en></project><project>
<id>3492</id><title_hr><![CDATA[Energetski učinkovit asinkroni bežični prijenos]]></title_hr><title_en><![CDATA[Energy efficient asynchronous wireless transmission]]></title_en><user_id>6379</user_id><user_firstLast_name>Tomislav Matić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2014-09</proposal_call><code>UIP-2014-09-6219</code><acronim><![CDATA[EEAWT]]></acronim><duration>01.09.2015 - 31.12.2018</duration><status>Završio</status><financ_value>105.904,60 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera Osijek, Fakultet elektrotehnike, računarstva i informacijskih tehnologija Osijek]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Electrical Engineering, Computer Science and Information Technology Osijek]]></institution_en><team_members_id>6386, 6383, 6454, 6349, 7056, 5092, 13651, 13497, </team_members_id><team_members_names><![CDATA[Marijan Herceg, Tomislav Švedek, Mario Vranješ, Ratko Grbić, Denis Vranješ, Denis Pelin, Josip Job, Leon Šneler, ]]></team_members_names><keywords_hr><![CDATA[bežični prijenos, asinkrona analogno-digitalna pretvorba, ultra-širokopojasni modulacijski postupci, bežične senzorske mreže, internet objekata]]></keywords_hr><keywords_en><![CDATA[wireless transmission, asynchronous analog-to-digital conversion, ultra-wideband modulation techniques, wireless sensor networks, internet of things]]></keywords_en><summary_hr><![CDATA[Kako bi se postigla energetska učinkovitost i smanjila površina integriranih sklopova za bežični prijenos, u posljednje se vrijeme primjenjuju asinkroni dizajn i širokopojasni modulacijski postupci. Veliki izazov pri projektiranju asinkronog bežičnog prijenosa je detekcija signala na strani prijemnika i uspostava više-korisničkog prijenosa. Prijedlog istraživačkih aktivnosti u sklopu ovog projekta je izrada energetski učinkovitih asinkronih integriranih sklopova za bežični prijenos analognog signala primjenjivih u senzorskim čvorovima bežičnih senzorskih mreža. Predloženi sustav se može podijeliti na dva podsustava, analogno-digitalni pretvornik i modulator za bežični prijenos. Na taj se način projektne aktivnosti mogu podijeliti u dvije faze. Prva faza uključuje izradu asinkronog analogno-digitalnog pretvornika, dok druga faza uključuje aktivnosti u izradi modulatora temeljenog na ultra-širokopojasnom (UWB) generatoru impulsa. Za izradu analogno-digitalnog pretvornika primjenjivat će se asinkroni sigma-delta modulator i različite tehnike temeljene na detekciji razine signala, dok će se za izradu UWB modulatora razmatrati modulacijske tehnike za digitalne ulazne signale. Zbog jako uskog impulsa i načina rada s iznimno niskim faktorom ispune, UWB modulacijski postupci su atraktivan izbor za energetski učinkovit bežični prijenos. Razvoj postojećih i izrada novih širokopojasnih modulacijskih postupaka u sklopu ovog projekta provodit će se s ciljem postizanja energetske učinkovitosti. Kako bi se zadovoljili osnovni ciljevi energetske i površinske učinkovitosti, prijenosni sustav će biti izrađen u CMOS procesu.]]></summary_hr><summary_en><![CDATA[To achieve high circuit power and size efficiency in wireless transmission circuits, recent contributions propose asynchronous design and spread spectrum communications. A great challenge in asynchronous wireless transmission is to accomplish signal detection at the receiver side and to establish multiuser transmission. The proposal of research activities in this project will be the design of low power asynchronous circuits for wireless transmission of analog input signals applicable as sensor nodes in short distance wireless sensor networks. The proposed system can be divided into two major subsystems consisting of the analog-to-digital (A/D) converter and the modulator for wireless transmission. Hence, the project activities can be divided into two major phases. The first phase will include asynchronous ADC design, where novel circuit architectures will be investigated, while the second phase will include activities on the modulator design incorporating ultra-wideband (UWB) pulse generators. The asynchronous sigma-delta modulator and various level crossing schemes will be investigated for A/D conversion, while UWB modulation techniques will be considered for the digitized signal modulation. Due to narrow pulse width and duty-cycled operation, UWB modulation techniques are a reasonable choice for the energy efficient wireless transmission. Evaluation of existing and development of new spread spectrum modulation techniques will be carried out to improve energy efficiency. To satisfy the major size and power consumption requirements, the transmission circuitry will be designed in CMOS process.]]></summary_en></project><project>
<id>3494</id><title_hr><![CDATA[Društvena stratifikacija u Hrvatskoj: strukturni i subjektivni aspekti]]></title_hr><title_en><![CDATA[Social stratification in Croatia: structural and subjective aspects]]></title_en><user_id>13642</user_id><user_firstLast_name>Karin Doolan</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2014-09</proposal_call><code>UIP-2014-09-3134</code><acronim><![CDATA[STRAT]]></acronim><duration>01.07.2016 - 19.12.2020</duration><status>Završio</status><financ_value>63.335,32 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Sociologija, </scie_field_hr><scie_field_en>Sociology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zadru]]></institution_hr><institution_en><![CDATA[University of Zadar]]></institution_en><team_members_id>13306, 13384, 13296, 12672, 13241, 21265, 11230, 21272, 4944, 20316, 21073, </team_members_id><team_members_names><![CDATA[Valerija Barada, Branko Ančić, Sven Marcelić, Mladen  Domazet, Krešimir Krolo, Ivana Jugović, Jaka Primorac, Petra Rodik, Željka Tonković, Drago Župarić-Iljić, Drazen Cepic, ]]></team_members_names><keywords_hr><![CDATA[stratifikacija, klase, Bourdieu, nejednakosti, mješovite metode]]></keywords_hr><keywords_en><![CDATA[stratification, class, Bourdieu, inequalities, mixed methods ]]></keywords_en><summary_hr><![CDATA[Cilj predloženoga projekta je oživjeti klasnu analizu u Hrvatskoj budući da u Hrvatskoj od kasnih 1980-ih postoji praznina na tom važnom istraživačkom polju. U sociološkoj tradiciji, “skliski” koncept “klase” koristi se kako bi se teoretiziralo i istraživalo društvene nejednakosti. Pridjev “sklizak” u ovom se kontekstu upotrebljava kako bi označio tekuće rasprave o tome je li klasa i dalje relevantan analitički koncept, kao i rasprave oko različitih tradicija konceptualiziranja klase. Suprotstavljeni suvremeni pristupi klasi kreću se od neomarksističkih i neoveberijanskih pristupa u klasnoj analizi do ponovnog oživljavanja Bourdieuova klasnog modela, te primjerice istraživanja “duševne ekonomije klase”. Pristup analizi društvenih klasa iznesen u ovome projektu nadahnut je Bourdieuovim radom na temu društvenih nejednakosti. Bourdieuova (1992) klasna analiza sastoji se od dvaju “trenutaka”: konstruiranja objektivnih struktura identificiranjem distribucije resursa (kulturnih, ekonomskih, društvenih) koji čine ograničenja djelovanju, te procesa kojima se ta ograničenja (iznova) stvaraju. Drugim riječima, fokus je na utvrđivanju “objektivnih” klasnih pozicija, kao i na tomu kako se one manifestiraju u rutinskim aktivnostima, a taj je pristup preuzet i u ovome projektu. Podaci iz upitnika vezani uz ekonomski, kulturni i društveni kapital ljudi prikupljat će se na nacionalno reprezentativnom uzorku  stanovnika Hrvatske, i na temelju toga razvit će se klasni model hrvatskoga društva. Osim toga, provest će se i 120 narativnih intervjua kojima će se zabilježiti životne priče ciljno odabranog uzorka muškaraca i žena koji žive u različitim hrvatskim regijama i imaju različite klasne pozicije. Svrha tih razgovora je istražiti biografsko djelovanje klasa, u smislu poimanja samoga sebe, svakodnevnih praksi te u kriznim vremenima. Predloženi nacrt mješovitih metoda istraživanja omogućit će istraživanje kako strukturnih tako i subjektivnih vidova društvene stratifikacije. ]]></summary_hr><summary_en><![CDATA[The objective of this proposed project is to revive class analysis in Croatia since there has been a gap in this important research field in Croatia since the late 1980s. In the sociological tradition, the “slippery” concept of “class” has been used to theorise and research social inequalities. The adjective “slippery” is used to signal running debates on whether class is still a viable analytical concept, as well as debates surrounding diverse traditions of conceptualising class. Contemporary debates range from neo-Marxist and neo-Weberian perspectives to revitalised versions of Bourdieu’s class model, as well as more micro-level approaches in class analysis including research on the “psychic economy of class”. This project is inspired by Bourdieu’s work on social inequalities. Bourdieu’s (1992) class analysis consists of two “moments”: the construction of objective structures by identifying the distribution of resources (cultural, economic, social) that act as external constraints bearing on practices and the exploration of how people subjectively (re)create these structures. In other words, there is a focus on identifying “objective” class locations, as well as how these locations are practised in routine activities; this is the approach taken up by this project. Questionnaire data on people’s economic, cultural and social capital will be collected from a nationally representative sample of people living in Croatia, on the basis of which a class model of Croatian society will be developed. In addition, 120 life story interviews with a purposive sample of women and men living in different regions of Croatia and occupying different class locations will be conducted. The purpose of the interviews is to explore how class works biographically, both in terms of self-identification, everyday practices and at times of crisis. The mixed methods approach will enable the exploration of both structural and subjective aspects of social stratification. ]]></summary_en></project><project>
<id>3495</id><title_hr><![CDATA[Kooperativno upravljanje iskustvenom kvalitetom u pokretnim mrežama za interaktivne višemedijske aplikacije u računalom oblaku]]></title_hr><title_en><![CDATA[Cooperative Quality of Experience Management for Interactive Cloud-Based Multimedia Applications in Mobile Networks]]></title_en><user_id>3964</user_id><user_firstLast_name>Lea Skorin-Kapov</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2014-09</proposal_call><code>UIP-2014-09-5605</code><acronim><![CDATA[Q-MANIC]]></acronim><duration>01.07.2015 - 30.06.2018</duration><status>Završio</status><financ_value>64.503,28 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, Elektrotehnika, </scie_field_hr><scie_field_en>Computer sciences, Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>932, 13031, 4451, 6269, 6704, 2775, 21062, </team_members_id><team_members_names><![CDATA[Maja Matijašević, Martín Varela, Aleksandra Čereković, Ivan Slivar, Dunja  Vučić, Mirko Sužnjević, Irena Oršolić, ]]></team_members_names><keywords_hr><![CDATA[Iskustvena kvaliteta, modeliranje iskustvene kvalitete, višemedijske aplikacije, računalni oblak, upravljanje iskustvenom kvalitetom]]></keywords_hr><keywords_en><![CDATA[Quality of Experience, QoE modelling, multimedia applications, cloud, QoE management]]></keywords_en><summary_hr><![CDATA[Zbog rasta broja novih pokretnih uređaja poput pametnih telefona i tableta, aplikacije i usluge namijenjene izvođenju na pokretnim uređajima su postale sastavni dio ljudske svakodnevice, sa značajnim utjecajem na ljudsku komunikaciju, učenje i zabavu. Potaknut zahtjevima poput skalabilnosti, fleksibilnosti i administracije, nastavio se trend migracije aplikacija u računalni oblak. Ono što i dalje ostaje ključni problem i razlikovno sredstvo između pružatelja usluga je ispunjavanje zahtjeva krajnjih korisnika s obzirom na očekivanu kvalitetu usluge, a što se naziva iskustvenom kvalitetom (QoE). Projekt Q-MANIC predložit će kooperativnu shemu za upravljanje iskustvenom kvalitetom, iskorištavajući nova znanja o iskustvenoj kvaliteti i poslovne modele usredotočene na kooperativne napore pružatelja usluga/usluga zasnovanih na računalnom oblaku i davatelja usluga u pokretnim mrežama kako bi se ostvarilo efikasnije upravljanje mrežnim resursima, a pritom i poboljšala iskustvena kvaliteta krajnjeg korisnika. Pored postojećih načina razmjene informacija u današnjim mrežama, bit će predloženi novi pristupi za koordinaciju i razmjenu informacija između aktora u postojećem vrijednosnom lancu pružatelja usluga. Bit će predloženi novi načini raspodjele resursa i novi algoritmi za prilagodbu usluge koji imaju u vidu različite strategije optimizacije. Kako bi pokazali korist i primjenjivost predloženog pristupa, prikazat ćemo dva slučaja uporabe koji predstavljaju primjer visoko interaktivnih i mrežno zahtjevnih višemedijskih aplikacija koje su dostavljaju putem pokretnih mreža (LTE/LTE-advanced/5G): usluga igranja u pokretu zasnovana na računalnom oblaku i usluga višekorisničkog video razgovora u pokretu. Oslonit ćemo se empirijski dobivene podatke kako bi specificirali modele iskustvene kvalitete i optimalne strategije za prilagodbu usluge. Shema za upravljanje iskustvenom kvalitetom koristit će mehanizme za upravljanje mrežom i strategije za prilagodbu aplikacije kako bi se poboljšala iskustvena kvaliteta i povećala efikasnost zauzeća resursa. Ključni doprinos bit će ugradnja kontekstualnih znanja i rezultata analize korisničkog ponašanja i interakcije u validirani model iskustvene kvalitete koji će biti korišten za efikasno upravljanje iskustvenom kvalitetom.]]></summary_hr><summary_en><![CDATA[With the proliferation of new mobile devices such as smartphones and tablets, mobile applications have become an integral part of our daily life activities, with a profound impact on the way people communicate, learn, or entertain. Driven by requirements such as scalability, flexibility, and administration, there is an increasing trend in migrating applications to the cloud. A key concern and differentiator between providers is meeting end users’ requirements in terms of service quality and expectations, referred to as Quality of Experience (QoE). The Q-MANIC project will propose a cooperative QoE management scheme exploiting new QoE knowledge and business models based on cooperative efforts between cloud/service providers and mobile network operators to achieve more efficient management of network/system resources, while enhancing end user QoE. Novel approaches for coordination and information exchange among actors involved in the service delivery chain will be proposed beyond those available in today&#39;s networks. Resource allocation and service adaptation algorithms will be proposed targeting different optimization strategies and taking into account multiple stakeholder perspectives. To demonstrate the benefits and applicability of the proposed approach, we address two use cases involving interactive, bandwidth intensive cloud-based applications delivered via mobile networks (LTE/LTE-advanced/5G): mobile cloud gaming and mobile multi-party video chat. We will rely on empirically obtained data to specify QoE models and optimal service adaptation strategies. The QoE management scheme will combine network management mechanisms and application adaptation strategies to bring improvements in QoE and efficiency of resource usage. A key contribution will be the incorporation of contextual knowledge and analysis of user behaviour and interactions into building validated QoE models that will be exploited in the context of QoE management.]]></summary_en></project><project>
<id>3501</id><title_hr><![CDATA[Ispitivanje reaktivnosti trombocita u različitim srčanožilnim bolestima]]></title_hr><title_en><![CDATA[Studies on PlAtelet REactivity Levels In difFErent CardioVascular Diseases]]></title_en><user_id>7462</user_id><user_firstLast_name>Davor  Miličić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-8403</code><acronim><![CDATA[SPARELIFE-CVD]]></acronim><duration>01.12.2015 - 30.11.2019</duration><status>Završio</status><financ_value>130.731,97 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Clinical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>1021, 3349, 5362, 7354, 7483, 7201, 7352, 13689, 7344, 4638, 7185, 4641, 12324, 985, 7313, 24919, 26203, </team_members_id><team_members_names><![CDATA[Boško Skorić, Maja Čikeš, Jure Samardžić, Miroslav Krpan, Jana Ljubas Maček, Željko Baričević, Marijan Pašalić, Hrvoje Jurin, Ivo Planinc, Bojan Biočina, Hrvoje  Gašparović, Mate Petričević, Davor Puljevic, Joško Bulum, Vedran Velagic, Zvonimir Ostojić, Dubravka Šipuš, ]]></team_members_names><keywords_hr><![CDATA[kardiovaskularne bolesti, reaktivnost trombocita, agregometrija, personalizirana kardiologija, klinički ishodi]]></keywords_hr><keywords_en><![CDATA[cardiovascular diseases, platelet reactivity, aggregometry, personalized cardiology, clinical outcomes]]></keywords_en><summary_hr><![CDATA[Predloženi projekt je nastavak dosadašnjeg rada u kojem se nastoji ispitati značaj reaktivnosti trombocita u različitim srčanožilnim oboljenjima te mogućnost da se individualiziranom primjenom antitrombocitnih lijekova prema vrijednostima reaktivnosti trombocita poboljšaju klinički ishodi. Istraživanje je podijeljeno u pet cjelina koje će se paralelno provoditi. Prva cjelina obuhvaća nastavak istraživanja utjecaja povišene ostatne reaktivnosti trombocita i individualiziranog pristupa primjene antitrombocitne terapije u bolesnika s akutnim koronarnim sindromom. Druga cjelina će istraživati promjene reaktivnosti trombocita kod bolesnika nakon izvanbolničkog aresta koji se podvrgavaju protokolu terapijske hipotermije. Nedovoljno je istraženo kako kontrolirano snižena tjelesna temperatura utječe na agregacijsku kaskadu in vivo, osobito u bolesnika koji se liječe antitrombocitnim lijekovima. Treća cjelina će obuhvatiti bolesnike koji se liječe mehaničkom cirkulacijskom potporom zbog terminalne faze srčanog popuštanja. U toj skupini evaluirat ćemo reaktivnost trombocita povezanu s korištenjem izvantjelesnog krvotoka odnosno mehaničkih srčanih crpki i povezanost s trombozama uređaja i s krvarenjima. U četvrtoj cjelini istraživat ćemo ulogu funkcije trombocita u sekundarnoj plućnoj hipertenziji uzrokovanoj bolešću miokarda lijeve klijetke (WHO tip II). Povezanost reaktivnosti trombocita i težine bolesti je već pokazana u primarnoj plućnoj hipertenziji, ali ne i u mnogo češćoj, plućnoj hipertenziji tipa II. Rezultati bi mogli pridonijeti poznavanju patofiziologije sekundarne plućne hipertenzije tipa II s mogućim terapijskim implikacijama, jer se namjerava ispitati, moduliraju li promjene reaktivnosti trombocita vazoaktivni odgovor na prostaglandin E1. Posljednja, peta cjelina će biti posvećena ispitivanju prognostičkog značenja reaktivnosti trombocita na razvoj koronarne vaskulopatije u bolesnika nakon presadbe srca što do sada nije istraživano.]]></summary_hr><summary_en><![CDATA[The proposed project represents a continuation of our previous work which will examine the significance of platelet reactivity (PR) in a variety of cardiovascular diseases and the potential of individualized approach in antiplatelet therapy regimen based on the values of PR to improve clinical outcomes. The research will be divided into five arms that will be conducted simultaneously. The first arm will be the continuation of our research on the impact of high on-treatment platelet reactivity and individualized approach to the application of antiplatelet therapy in patients with acute coronary syndrome. The second arm will study the changes of PR in patients with out-of-hospital cardiac arrest who undergo therapeutic hypothermia protocol. It is insufficiently explored how a controlled low body temperature affects the aggregation cascade in vivo, particularly in patients treated with antiplatelet drugs. The third arm will include patients with implanted mechanical circulatory support (MCS) due to end-stage heart failure. In this group we will evaluate the association of PR levels in patients with MCS and device thromboses as well as bleeding events. In the fourth study arm we will investigate the role of platelet function in secondary pulmonary hypertension caused by left ventricular myocardial disease (WHO type II). Correlation between PR and the severity of the disease has been shown in primary pulmonary hypertension, but not in much more frequent, type II pulmonary hypertension. The results might contribute to the knowledge of the pathophysiology of pulmonary hypertension, with potential therapeutic implications as we intend to examine whether the changes in PR modulate the response to vasoactive prostaglandin E1. The last, fifth arm will be devoted to heart transplant patients where we will examine the prognostic significance of PR in the development of coronary vasculopathy after heart transplantation which has not been investigated so far.]]></summary_en></project><project>
<id>3515</id><title_hr><![CDATA[Razvoj biokompatibilnih materijala na temelju hidroksiapatita za primjene u inženjerstvu koštanog tkiva ]]></title_hr><title_en><![CDATA[Development of Biocompatible Hydroxyapatite Based Materials for Bone Tissue Engineering Applications]]></title_en><user_id>12662</user_id><user_firstLast_name>Hrvoje  Ivanković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-3752</code><acronim><![CDATA[HATEA]]></acronim><duration>01.03.2017 - 28.02.2021</duration><status>Završio</status><financ_value>131.772,65 eur</financ_value><scie_area_hr>Tehničke znanosti, Biomedicina i zdravstvo, Prirodne znanosti, Biotehničke znanosti, </scie_area_hr><scie_area_en>Technological sciences, Biomedicine and health sciences, Natural sciences, Biotechnical sciences, </scie_area_en><scie_field_hr>Kemijsko inženjerstvo, Kemija, Biologija, Strojarstvo, Temeljne tehničke znanosti, Kliničke medicinske znanosti, Veterinarska medicina, Biotehnologija, Biotehnologija u biomedicini, </scie_field_hr><scie_field_en>Chemical engineering, Chemistry, Biology, Mechnical engineering, Basic engineering sciences, Clinical sciences, Veterinary medicine, Biotechnology, Biotechnology in Biomedicine, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet kemijskog inženjerstva i tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Chemical Engineering and Technology]]></institution_en><team_members_id>13014, 12343, 12661, 12336, 13487, 6475, 12976, 12334, 13266, 13408, 22929, 12914, 22646, 6099, </team_members_id><team_members_names><![CDATA[Marica  Ivanković, Dajana Milovac, Anamarija Rogina, Sebastijan Orlić, Gloria Gallego-Ferrer, Zdenka Keran, Petar Piljek, Dragana Gabrić Pandurić, Elizabeta Gjorgievska, Damir Mihelić, Antonia  Ressler, Klaudia Paljar, Leonard Bauer, Maja Antunović, ]]></team_members_names><keywords_hr><![CDATA[inženjerstvo koštanog tkiva, skelet, hidroksiapatit, biorazgradivi polimeri, in vitro/vivo ponašanje]]></keywords_hr><keywords_en><![CDATA[bone tissue engineering, scaffold, hydroxyapatite, biodegradable polymers, in vitro/vivo behaviour]]></keywords_en><summary_hr><![CDATA[Izazov za inženjerstvo koštanog tkiva je razvoj odgovarajućih skeleta (engl. scaffold) koji omogućavaju dobru integraciju s okolnim tkivom. Posljednjih godina intenzivno se istražuje hidroksiapatit (HAp) zbog njegove kemijske i strukturne sličnosti s anorganskom matricom prirodne kosti i odlične bioaktivnosti. Nedostatak HAp-a su njegova slaba mehanička svojstva pa se obično kombinira s polimerima i metalima. U prethodnim istraživanjima pripravili smo visoko porozne skelete na temelju HAp-a i poli(?-kaprolakton)-a (PCL) korištenjem jednostavnih i ekonomičnih postupaka. In vitro istraživanja sa stanicama MC3T3-E1 pokazala su da skeleti nisu toksični i da su odgovarajuća 3D podloga za prianjanje, umnažanje i diferenciranje stanica. Provedene su i preliminarne sinteze poroznih skeleta na temelju HAp-a i kitozana. Dobiveni su vrlo obećavajući rezultati uzimajući u obzir poroznost i međusobnu povezanost pora te netoksičnost materijala.Opći cilj ovog projekta je poboljšanje mehaničkih i bioloških svojstava biokompatibilnih materijala na temelju hidroksiaptita, posebice njihove sposobnosti poticanja aktivnog stvaranja kosti. Specifični ciljevi projekta su:  (1) sustavno istražiti utjecaj vrste i količine iona elemenata u tragovima (Mn, Si, Zn, Cu..) na biološko ponašanje skeleta;  (2) istražiti ponašanje skeleta in vivo, implantiranjem odabranih skeleta u oštećenja potkoljenične kosti kunića; (3) istražiti mogućnosti kanalnog kutnog prešanja za dobivanje novih HAp/titan kompozita za primjene u inženjerstvu koštanog tkiva.  Čvrsto vjerujemo da će projekt doprinijeti boljem razumijevanju sinteze, strukture i svojstava novih materijala za primjene u inženjerstvu koštanog tkiva. Razvoj novih skeleta na temelju HAp-a može imati pozitivne implikacije za društvo u smislu tretiranja i liječenja koštanih oštećenja te tako poboljšati kvalitetu života pacijenata, posebice starijih. Nadalje, ova istraživanja mogu otvoriti vrata novim primjenama skeleta u istraživanju matičnih stanica. ]]></summary_hr><summary_en><![CDATA[The challenge of bone tissue engineering (BTE) is to develop bone scaffolds that allow a good integration with the surrounding tissues. Particular systems of interest are scaffolds based on hydroxyapatite (HAp), due to its chemical and structural similarity to the inorganic matrix of natural bone and excellent bioactivity. To overcome disadvantages such as poor mechanical properties of HAp it has been combined with polymers and metals. In our previous studies highly porous HAp and poly(?-caprolactone),(PCL),- coated HAp scaffolds were prepared using simple and inexpensive methods. In vitro cell culture studies showed that scaffolds are nontoxic and provide an adequate 3D support for the attachment, proliferation and differentiation of MC3T3-E1 cells. Some preliminary studies on preparation of HAp/chitosan scaffolds showed promising results regarding porosity and interconnectivity of pores and nontoxicity.The overall objective of this project is to investigate methods to improve mechanical and biological properties of HAp-based materials especially the ability to propagate active bone formation. The specific objectives of the project are: (1) to investigate systematically the effect of dopants (Mn, Si, Zn, Cu..) on biological performance of the scaffolds (2) to assess in vivo biological performance of scaffolds by implanting the selected scaffolds in rabbits&#39; lower legs defects. (3) to investigate the potential of equal-channel angular pressing to produce novel HAp/titanium composites for BTE applications.We strongly beleive that the research will contribute to the better understanding of the synthesis, structure and properties of scaffolds for BTE applications. Development of novel HAp-based scaffolds could have positive implications for society in terms of treating and healing bone defects, improving quality of life for trauma patients and the elderly. Additionally, the research will open the door to new applications of scaffolds in stem cells research.]]></summary_en></project><project>
<id>3516</id><title_hr><![CDATA[Različiti učinci okolišno relevantnih mješavina metal temeljenih nanočestica i pesticida na faunu tla: Nove smjernice za procjenu rizika]]></title_hr><title_en><![CDATA[Diverse Effects of Environmentally Relevant Metal-based Nanoparticle and Pesticide Mixtures on Soil Fauna: A Novel Issue for Risk Assessment ]]></title_en><user_id>6027</user_id><user_firstLast_name>Branimir Hackenberger Kutuzović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-4459</code><acronim><![CDATA[DEFENSoil]]></acronim><duration>02.11.2015 - 01.11.2019</duration><status>Završio</status><financ_value>107.173,67 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Odjel za biologiju]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Department of Biology]]></institution_en><team_members_id>6022, 6798, 5347, 5348, 5901, 25219, </team_members_id><team_members_names><![CDATA[Davorka Hackenberger Kutuzović, Sandra Ečimović, Mirna  Velki, Željka Lončarić, Goran Palijan, Marija Kovačević, ]]></team_members_names><keywords_hr><![CDATA[metal temeljene nanočestice, toksičnost mješavina, procjena okolišnog rizika, fauna tla, gujavice, ekotoksikologija]]></keywords_hr><keywords_en><![CDATA[metal based nanoparticles, mixture toxicity, environmental risk assessment, soil fauna, earthworm, ecotoxicology]]></keywords_en><summary_hr><![CDATA[Tlo je neobnovljivi prirodni resurs karakteriziran mnogobrojnim procesima koji se uvelike mijenjaju kao posljedica povećanog antropogenog pritiska na okoliš. Pravilno i stabilno funkcioniranje tla nužan je preduvjet održivosti terestričkih ekoloških sustava, te bitan čimbenik u planiranju ljudskih aktivnosti u smislu održivog razvoja. Među brojnim zagađivalima prisutnima u okolišu pesticidi se, zbog njihove široke i uobičajene upotrebe, te utjecaja na neciljne organizme, smatraju jednima od glavnih zagađivala tla. Nanočestice (NP) su u novije vrijeme dovedene u središte pozornosti zbog sve veće zastupljenosti u poljoprivredi što naglašava važnost razumijevanja njihovih ekotoksikoloških učinaka. Cilj projektnog prijedloga je određivanje različitih učinaka mješavina NP i pesticida na neciljnim organizmima u tlu. Kako bi ostvarili navedene ciljeve predlažemo sveobuhvatno  ekotoksikološko istraživanje koje uključuje različite razine složenosti (preliminarna laboratorijska-eksperimenti u ograničenim okolišnim uvjetima), različite krajnje točke (molekularna-populacijska razina), različite scenarije izlaganja (jedan toksikant–mješavina, kratko-dugačko izlaganje, jednostruko–niz izlaganja) i uključivanje modelnih i nativnih organizama tla. Na temelju složenih eksperimentalnih podataka o toksičnim učincima odabranih pesticida i NP, izraditi će se predikcijski model pogodan za optimizaciju biomonitoringa opterećenja tla, te matrični modeli učinaka na razini populacija ispitivanih organizama. Iz modela će se procijeniti učinci istraživanih toksikanata, te odrediti uvjeti pod kojima modelirana populacija pruža odgovor na aplicirane toksikante i mijenja svoj potencijal odgovora na druge stresore. Očekivani rezultati poboljšati će znanje o toksičnosti smjesa na neciljne organizme tla, te o mogućim utjecajima i ekotoksikološkim karakteristikama metal temeljenih NP što će biti primjenjivo u procesu procjene okolišnog rizika pogodnim za tehnološki suvremene načine korištenja tla. ]]></summary_hr><summary_en><![CDATA[Soil is a non-renewable resource subjected to a series of degradation processes and increasing environmental pressure, driven or exacerbated by human activity. As the appropriate functioning of the soil is essential for terrestrial ecosystems and human activity the risk of its impairment should be taken very seriously. Among numerous pollutants present in the environment, pesticides, due to their wide and common usage and impact on non-target organisms, represent one of the major soil pollutants. More recently nanoparticles (NPs) have been brought into focus as the increased interest for their usage in agriculture highlights the importance of understanding its ecotoxicological effects. The proposed project aims to identify the various effects of NPs and pesticides mixtures on non-targeted soil organisms, but also to identify the interactions of metal-based NPs and pesticides. In order to deliver the specified objectives of the project we propose a comprehensive ecotoxicological research which includes various levels of complexity (from preliminary laboratory to semi-field experiments), different endpoints (from molecular to population level), different exposure scenarios (single-mixture, short-long, single application-sequence of applications) and inclusion of both model and native soil organisms. Additionally, based on experimental data on toxic effects of selected pesticides and metal-based NPs, population-level matrix models will be constructed. From the model outputs the effects of investigated toxicants will be assessed and used to establish under which set of conditions a modelled population will respond to applied toxicants and alter its potential to respond to other stressors. The expected results will improve the state of knowledge on toxicity of mixtures on non-targeted soil organisms and can be implemented in risk assessment process. Consequently, expected results can enhance soil protection and soil ecological sustainability.]]></summary_en></project><project>
<id>3529</id><title_hr><![CDATA[Kohortna studija rođenih na istočnojadranskim otocima]]></title_hr><title_en><![CDATA[CRoatian Islands&#39; Birth cohort Study]]></title_en><user_id>3126</user_id><user_firstLast_name>Saša Missoni</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2014-09</proposal_call><code>UIP-2014-09-6598</code><acronim><![CDATA[CRIBS]]></acronim><duration>01.11.2015 - 31.10.2018</duration><status>Završio</status><financ_value>107.702,30 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo, Prirodne znanosti, Društvene znanosti, Humanističke znanosti, Biotehničke znanosti, </scie_area_hr><scie_area_en>Biomedicine and health sciences, Natural sciences, Social sciences, Humanities, Biotechnical sciences, </scie_area_en><scie_field_hr>Javno zdravstvo i zdravstvena zaštita, Biologija, Temeljne medicinske znanosti, Nutricionizam, Etnologija i antropologija, </scie_field_hr><scie_field_en>Public health and health services, Biology, Basic Medical Sciences, Nutrition, Ethnology and anthropology, </scie_field_en><institution_hr><![CDATA[Institut za antropologiju]]></institution_hr><institution_en><![CDATA[Institute for Anthropological Research]]></institution_en><team_members_id>828, 1509, 815, 804, 813, 6673, 4523, 5909, 1040, 994, 968, 6763, 4399, 1431, 943, 7008, 4104, 1113, 12584, 1247, 12895, 5603, 4282, 13664, 7639, 7199, 18961, 18959, 4280, 4276, 18958, 18957, 22819, 22829, </team_members_id><team_members_names><![CDATA[Ana Perinić Lewis, Natalija Novokmet, Dubravka Havaš Auguštin, Jelena Šarac, Tena Šarić, Noël Cameron, Schell Lawrence, Ellen Demerath, Miran Čoklo, Alen Šelović, Sanja Musić Milanović, Tamara Poljičanin, Vesna Pavlov, Martina Šunj, Ljiljana Muslić, ŽELJKO Romić, Biserka  orehovec, Veselin Škrabić, Olgica Martinis, Deni Karelović, Matea Zajc Petranović, Mirjana Turkalj, Ivana Banić, Denis Polančec, Marcel Lipej, Adrijana Miletić Gospić, Deana Švaljug, Ivana Unić Šabašov, Jelena Živković, Sandra Bulat Lokas, Lucija Zenić, Ana Žižić, Emily Petherick, IRENA BRALIĆ, ]]></team_members_names><keywords_hr><![CDATA[metabolički sindrom, kohortna studija rođenih, rani razvoj, prevencija, čimbenici rizika]]></keywords_hr><keywords_en><![CDATA[metabolic syndrome, birth cohort, early development, prevention, risk factors]]></keywords_en><summary_hr><![CDATA[Metabolički sindrom (MetS) je vodeći uzrok obolijevanja i smrtnosti, s velikim utjecajem na zdravlje stanovništva i visokim troškovima liječenja. Njegova prevalencija je više od 30 % u općoj populaciji Hrvatske, uz posebno visoku stopu na hrvatskim otocima, do 58 %. Specifična obilježja istočnojadranskih otoka (genetički izolati s visokom razinom srođivanja, s miješanjem tradicionalnog i tranzicijskog životnog stila te stalnim depopulacijskim procesima) predstavljaju temelj za razvoj obrazaca čimbenika rizika koji utječu na pojavu MetS-a. Ovaj projekt je pilot-studija čiji su ciljevi: procijeniti prevalenciju poznatih čimbenika rizika (bioloških, ekoloških i ponašajnih) za razvoj MetS-a u ciljnim hrvatskim populacijama istočnojadranskih otoka i susjednog kopnenog područja te koristiti dobivene rezultate kao temelj za razvoj strategije intervencije. Populacijske kohortne studije trudnica i rođene djece su posebno pogodne za proučavanje ranih odrednica zdravlja i bolesti, koje se javljaju još u fetalnom razdoblju i djetinjstvu. Longitudinalni istraživački pristup će se primijeniti na reprezentativnom uzorku od 713 ispitanika u svakoj od dviju skupina: trudnica i njihove djeca u ciljnim populacijama otoka (Hvar, Brač i Vis) i susjednog kopnenog područja Splitsko-dalmatinske županije. Ishod projekta bit će otkrivanje skupova bitnih čimbenika rizika razvoja MetS-a u ciljnim populacijama. Dugoročni ishod je postupno razvijanje osnove djelotvorne strategije intervencije usmjerene na bitne čimbenike rizika nastanka MetS-a. Važnost nalaza ove pilot-studije je stvaranje temelja budućeg usmjerenijeg, populacijski prilagođenog modela rane intervencije, uključivanjem velikog broja bitnih čimbenika rizika za razvoj MetS-a, što će predstavljati značajan doprinos javnom zdravlju. Saznanja i iskustva stečena na temelju provedenih istraživanja doprinijet će stvaranju učinkovitijih programa promocije zdravlja, uzimajući u obzir utvrđene lokalne sociokulturne i okolišne specifičnosti.]]></summary_hr><summary_en><![CDATA[Metabolic syndrome (MetS) is the leading cause of high morbidity and mortality, with enormous impact on population health and medical costs. Its prevalence is more than 30% in the general Croatian population, with especially high rate on Croatian islands, up to 58%. Specific features of the Eastern Adriatic Islands (EAI) (genetic isolates with high level of inbreeding, mixing traditional and transitional lifestyle and continuous depopulation processes) represent a basis for development of specific MetS risk factor patterns. This project is a pilot study with the aims to: assess the prevalence of known risk factors (biological, environmental and behavioral) for the MetS in EAI and nearby mainland area of the targeted Croatian populations and to use this information as a base to develop an intervention strategy. Population-based pregnancy and birth cohort studies are particularly salient for studying early origins of health and disease that begin in fetal life and infancy. A longitudinal approach will be used on a representative sample of 713 participants in each group: pregnant women and children in the targeted populations of the islands (Hvar, Brač and Vis) and nearby mainland area of of the Split-Dalmatia County. The outcome of the project is revealing sets of relevant risk factors for the development of MetS in the studied Croatian populations. The long-term outcome is progressive development of a base for an effective intervention strategy, directed at relevant risk factors for MetS. The importance of this pilot study is developing foundations for a better focused population adjusted model of early intervention in the future. It will include a large number of relevant risk factors for MetS, which will contribute to beneficial public health outcomes. Knowledge and experiences, acquired in this research will contribute to the creation of programs for health promotion, taking into account local socio-cultural and environmental characteristics.]]></summary_en></project><project>
<id>3531</id><title_hr><![CDATA[Utjecaj promjena termohaline cirkulacije u istočnom Mediteranu na planktonske zajednice u južnom Jadranu:ekološki i genetički pristup]]></title_hr><title_en><![CDATA[Influence of thermohaline circulation variations in the Eastern Mediterranean on the plankton community of the South Adriatic: ecological and genetical approach]]></title_en><user_id>1051</user_id><user_firstLast_name>Mirna Batistić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-2945</code><acronim><![CDATA[AdMedPlan]]></acronim><duration>01.09.2015 - 31.08.2019</duration><status>Završio</status><financ_value>95.162,25 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, Kemija, Geofizika, </scie_field_hr><scie_field_en>Biology, Chemistry, Geophysics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Dubrovniku]]></institution_hr><institution_en><![CDATA[University of Dubrovnik]]></institution_en><team_members_id>2889, 3277, 3992, 7600, 13469, 3160, 2977, 2987, 2911, 1519, 2979, </team_members_id><team_members_names><![CDATA[Nenad Jasprica, Davor Lučić, Jakica Njire, Miroslav Gacic, Giuseppe CIVITARESE, Rade Garić, Iris Dupčić Radić, Marijeta  Čalić, Enis Hrustić, Marijana Miloslavić, Ana Car, ]]></team_members_names><keywords_hr><![CDATA[Plankton, alohtone vrste, termohaline cirkulacije, BIOS mehanizam,  dugoročne promjene, južni Jadran, istočni Mediteranean]]></keywords_hr><keywords_en><![CDATA[Plankton, alien species, thermohaline circulations, BIOS mechanism, long-term changes, South Adriatic, East Mediteranean]]></keywords_en><summary_hr><![CDATA[Projekt se temelji na postojanju Bimodalnog oscilirajućeg sustava (BiOS – “Bimodal Oscillating System”), koji djeluje kao povratni mehanizam između Jadranskog i Jonskog mora i rezultira dekadnim promjena u cirkulaciji Sjevernojonskog vrtloga, čime utječe na advekciju ili Modificirane atlantske vode ili Levantinske / Istočnomediteranske vode u Jadran. Advekcija različitih vodenih masa u Jadran je potencijalno jedan od glavnih čimbenika koji utječe na jadranski ekosustav. Glavni mogući utjecaji BiOS-a na jadranski ekosustav su kroz: i) promjenu termohalinih svojstava i razliku gustoće između površinskih i dubokih slojeva južnog Jadrana, koji utječu na zimska konvektivna miješanja; ii) utjecaj na autotrofnu biomasu zbog promjena u koncentraciji nutrijenata; iii) donos različitih vrsta alohtonih organizama u Jadransko i Jonsko more. Cilj ovog projekta je utvrditi stupanj utjecaja advekcije različitih vodenih masa na ekosustav otvorenog južnog Jadrana, prvenstveno kroz praćenje promjena u planktonskim zajednicama, koje prve reagiraju na promjene u ekosustavu zbog kratkog životnog ciklusa i položaja u hranidbenom lancu. Također, primijenit ćemo filogeografske metode, koje podrazumijevaju uporabu jezgrinih i mitohondrijskih genetičkih markera, s ciljem utvrđivanja podrijetla stranih vrsta koje ulaze u Jadran te procjene utjecaja BIOS-a na genetički sastav jadranskih planktonskih populacija, donosom genetički različitih jedinki iz različitih dijelova Mediterana. Točni mehanizmi utjecaja ulaska vodenih masa na produkciju u Jadranu slabo su poznati. Njihovo razumijevanje omogućit će nam predviđanje ulova sitne plave ribe, što bi nam moglo poslužiti kao temelj za jedinstveno upravljanje i održivo ribarstvo kao važne grane hrvatskog gospodarstva.]]></summary_hr><summary_en><![CDATA[This project is based on the existence of the Bimodal Oscillating System (BIOS), a feedback mechanism between the Adriatic and Ionian Sea which results in decadal changes of the Northern Ionian Gyre circulation and consequently on the prevalent advection of either Modified Atlantic Water (MAW) or Levantine/Eastern Mediterranean waters into the Adriatic. The advection of different water masses into the Adriatic is potentially one of the main factors affecting the Adriatic ecosystem. The major potential modes of influence of BiOs on the Adriatic ecosystem are: i) by changing buoyancy content in the South Adriatic which drives the winter convective mixing processes; ii) through impact on the autotrophic biomass due to the change in nutrient availability; iii) by bringing different types of allochthonous organisms into the Adriatic and Ionian Sea. The goal of this project is to determine the magnitude of the impact of alternate advection of water masses on the pelagic ecosystem of the South Adriatic, primarily through tracking the changes in plankton communities, which are the first to react in the ecosystem because of their short life cycle and position in the food chain. We will apply phylogeographic methods, which include the usage of nuclear and mitochondrial genetic markers, in order to determine the origin of alien species entering the Adriatic and to assess the influence of BiOS on genetic composition of Adriatic zooplankton communities through the advection of individuals from different parts of Mediterranean basin. The exact mechanisms of influence of the entering water masses on production of the Adriatic are poorly known. Its comprehension could allow forecasting of small  pelagic fish catches which could serve as a basis for sustainable management of the fisheries, an important part of Croatian economy.]]></summary_en></project><project>
<id>3537</id><title_hr><![CDATA[Napredna metodologija projektiranja prekidačkih istosmjernih pretvornika]]></title_hr><title_en><![CDATA[Advanced design methodology for switching DC-DC converters]]></title_en><user_id>7714</user_id><user_firstLast_name>Adrijan Barić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-6405</code><acronim><![CDATA[AdvaDCDC]]></acronim><duration>01.06.2015 - 30.06.2019</duration><status>Završio</status><financ_value>129.802,91 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, Temeljne tehničke znanosti, </scie_field_hr><scie_field_en>Electrical engineering, Basic engineering sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>13699, 13703, 13704, 7123, 13705, </team_members_id><team_members_names><![CDATA[Vladimir Čeperić, Raul Blečić, Tvrtko  Mandić, Igor Krois, Josip Bačmaga, ]]></team_members_names><keywords_hr><![CDATA[projektiranje integriranih sklopova, istosmjerni pretvornici, elektronički  sklopovi snage, galij-nitrid tranzistori, electromag. kompatibilnost]]></keywords_hr><keywords_en><![CDATA[integrated circuit design, DC-DC converters, power electronics, GaN transistors, electromagnetic compatibility]]></keywords_en><summary_hr><![CDATA[Napredna metodologija projektiranja prekidačkih istosmjernih pretvornika razvijena je u ovom projektu. Gornja sklopka, donja sklopa, pobudni i upravljački sklopovi integrirani su u jednom pakiranju, što minimizira utjecaj parazitnih elemenata i omogućava prekapčanja do 10 MHz. Razvit će se pobudni sklop s visokopreciznom kontrolom signala gornje i donje sklopke, što će omogućiti optimiranje mrtvog vremena s obzirom na efikasnost pretvaranja i smanjenje gubitaka za bilo koju kombinaciju parametara pakiranja integriranog sklopa, vanjskih komponenata i tiskane pločice. Posebna je pažnja posvećena projektiranju sklopa za pomak istosmjernog nivoa gornje sklopke. Osim što služi kao pobudni sklop za sklopke velike struje koje se nalaze na čipu, razvijeni pobudni sklop pobuđuje i vanjske pinove integriranog sklopa kako bi omogućio korištenje vanjskih sklopki. Galij-nitrid (GaN) i silicij-karbid (SiC) poluvodički elementi predstavljaju obećavajuće rješenje za visokonaponske i visokoefikasne pretvornike. Istosmjerni pretvornici koji koriste GaN/SiC tranzistore mogu se optimirati korištenjem prethodno razvijenog pobudnog sklopa. Razvijena metodologija omogućit će evaluaciju efikasnosti GaN i SiC elemenata u visokonaponskim prekidačkim primjenama kao i projektiranje kvalitetno optimiranih pretvornika. Tiskana pločica na koju je zalemljen čip pretvornika predstavlja sljedeći ključni dio dizajna pretvornika i ima dominantni utjecaj na određivanje elektromagnetske kompatibilnosti i termičkih svojstava pretvornika. Razvit će se simulacijsko okruženje koje omogućava elektromagnetsko-termičku kosimulaciju istosmjernih pretvornika. Provest će se statistička analiza parametara tiskane pločice i pakiranja integriranog sklopa kako bi se osiguralo da varijacije u proizvodnji ne narušavaju pouzdanost i efikasnost projektiranih pretvornika. ]]></summary_hr><summary_en><![CDATA[Advanced design methodology for switching DC-DC converters is developed. The low-side and high-side switch, their drivers and the control circuitry are integrated into one package which minimizes the parasitic elements and allows switching frequencies up to 10 MHz. A driving-signal circuitry with high-precision adjustable timings is developed. This will allow the optimisation of dead-times with respect to the power conversion efficiency of a converter for any given set of the parameters of the integrated circuit (IC) package, external components and a printed circuit board (PCB). A special attention is given to the design of a level-shifter for a high-side switch. Besides driving the on-chip power switches, the developed driving signal circuitry is routed to external pins of the IC package to enable driving of the externally connected switches. Gallium-nitride (GaN) and silicon-carbide (SiC) semiconductor devices present a promising solution for a high-voltage and high-efficiency power conversion. In order to design a highly efficient converter for high-voltage switching applications by using GaN and SiC power transistors, the GaN/SiC DC-DC converter will be optimised by using adjustable driving-signal circuitry, which is designed at the beginning of the project. The developed methodology will allow the evaluation of the efficiency of the GaN and SiC devices in high-voltage switching applications as well as highly optimised design of the converters. The PCB makes a large part of the design and it has a dominant effect in determination of the electromagnetic compatibility and thermal properties of the converter. A simulation environment which will allow the electromagnetic-thermal co-optimisation of DC-DC converters will be developed. A statistical analysis of the parameters of a PCB and an IC package will be performed to ensure that the variations in the manufacturing process do not compromise the reliability and the efficiency of the designed converters.]]></summary_en></project><project>
<id>3538</id><title_hr><![CDATA[Gradovi hrvatskog srednjovjekovlja: urbane elite i urbani prostor ]]></title_hr><title_en><![CDATA[Cities of the Croatian Middle Ages: Urban Elites and Urban Space]]></title_en><user_id>421</user_id><user_firstLast_name>Irena  Benyovsky Latin</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-7235</code><acronim><![CDATA[URBES]]></acronim><duration>15.09.2015 - 14.09.2019</duration><status>Završio</status><financ_value>60.684,85 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Povijest, </scie_field_hr><scie_field_en>History, </scie_field_en><institution_hr><![CDATA[Hrvatski institut za povijest]]></institution_hr><institution_en><![CDATA[Croatian Institute of History]]></institution_en><team_members_id>633, 330, 383, 436, 534, 1036, 3987, 466, 384, 535, 6365, 509, 476, 11259, 460, </team_members_id><team_members_names><![CDATA[Marija Karbić, Zrinka Pešorda Vardić, Gordan Ravančić, Ante Birin, Dušan  Mlacović, Danijela Doblanović, Ratko Vučetić, Marija Mogorović Crljenko, Ivana Lazarević, Tonija Andrić, Ivana Haničar Buljan, Zrinka Nikolić Jakus, Bruno Škreblin, Anton Ravnikar, Sandra Begonja, ]]></team_members_names><keywords_hr><![CDATA[urbane elite, urbani prostor, hrvatsko srednjovjekovlje, gradovi, prozopografija, socijalna topografija]]></keywords_hr><keywords_en><![CDATA[urban elites, urban space, Croatian Middle Ages, cities, prosopography, social topography]]></keywords_en><summary_hr><![CDATA[U središtu ovog projekta je odnos između prostora i društva u gradovima hrvatskog srednjovjekovlja, odnos koji je u recentnoj međunarodnoj historiografiji naglašen kao ključan za razumijevanje urbane povijesti srednjega vijeka. Fokus projekta URBES su odabrani gradovi srednjovjekovne Slavonije (Gradec i Varaždin) i odabrani istočnojadranski gradovi, od istarskih komuna na sjeveru do Dubrovnika na jugu. Ovaj projekt istražuje razvijeni i kasni srednji vijek (trinaesto do šesnaesto stoljeće). Glavna hipoteza URBES-a je da su elite središnja društvena grupa odgovorna za urbane razvoje. Cilj projekta URBES je pružiti odgovore na pitanja kao: koja je bila uloga urbanih posjeda (s obzirom na njihovu veličinu, poziciju i kontinuitet) u oblikovanju srednjovjekovnih elita? Kako su se elite u odabranim gradovima hrvatskog srednjovjekovlja transformirale s obzirom na gradski prostor? Koji je bio njihov utjecaj na urbani prostor, i kakva je bila njihova prisutnost u urbanom prostoru? Na temelju bogatih postojećih baza podataka, projekt će rekonstruirati i analizirati gustu mrežu obitelji, kućanstava, nekretnina i kuća u odabranim gradovima i pratiti njihov razvoj tijekom vremena da bi se dobio novi uvid u društvene strukture i urbani prostor. Iako su gradovi hrvatskog srednjovjekovlja u središtu projekta URBES, projekt se namjerava fokusirati na pitanja koja nadilaze problem pojedinih gradova kako bi se uspoređivali slični fenomeni u širem geografskom i političkom kontekstu, te kako bi pratili rezidencijalnu mobilnost urbanih elita. Također, projekt predlaže interdisciplinarni pristup i korištenje relevantnih informatičkih mogućnosti.]]></summary_hr><summary_en><![CDATA[At the centre of this project is the relationship between the space and the society in  cities of Croatian Middle Ages, a relationship that in recent international historiography has been stressed as key to understanding of the urban history of the Middle Ages. The foci of URBES project are selected medieval Slavonian towns (Gradec and Varaždin) and selected Eastern Adriatic towns, from Istrian communes in the north to Dubrovnik in the south. This project examines High and Late Middle Ages (thirteenth to mid-sixteenth centuries). The main hypothesis of the URBES project is that the elites were central to urban developments. The goal of the URBES project is to provide answers to questions such as: What was the role of the urban estates (with regard to its size, location and continuity) in the formation of medieval elites? How did urban elites in chosen towns of Croatian Middle Ages transform in relation to urban space? What was their influence upon the urban space, and their presence in the urban space? On the basis of the rich extant databases, the project will reconstruct and analyse dense matrix of families, households, properties and buildings in chosen towns, and trace their evolution over time, gaining new insights into social structures and urban space. Although the cities of the Croatian Middle Ages are in the centre of URBES, the project will focus on the issues that go beyond the scale of individual towns in order to make comparisons of similar phenomena between cities and towns in a broader geographical and political context, and to trace residential mobility of the urban elites. Also, the project proposes the interdisciplinary approach, with the use of relevant IT  possibilities.]]></summary_en></project><project>
<id>3540</id><title_hr><![CDATA[Uloga strukturnih reformi u poticanju vanjske konkurentnosti zemalja Europske unije]]></title_hr><title_en><![CDATA[The role of structural reforms in boosting external competitiveness in European Union countries]]></title_en><user_id>5806</user_id><user_firstLast_name>Boris Cota</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-5476</code><acronim><![CDATA[ROSPEC]]></acronim><duration>01.05.2015 - 30.04.2019</duration><status>Završio</status><financ_value>34.352,33 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, </scie_field_hr><scie_field_en>Economy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Ekonomski fakultet u Zagrebu]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Economics and Business]]></institution_en><team_members_id>5144, 6292, 4716, 13295, 4460, </team_members_id><team_members_names><![CDATA[Nataša Erjavec, Zrinka Lukač, Željko  Bogdan, Velibor Mačkić, Lucija Rogić, ]]></team_members_names><keywords_hr><![CDATA[Ekonomska politika, strukturne reforme, vanjska konkurentnost, tekući račun, izvoz, cjenovna konkurentnost, necjenovna konkurentnost, tržište proi]]></keywords_hr><keywords_en><![CDATA[economic policy, structural reforms, external competitiveness, current account, export, price competiveness, non-price competiveness, product market, ]]></keywords_en><summary_hr><![CDATA[Cilj projekta je analizirati učinke strukturnih reformi na vanjsku konkurentnost u zemljama EU. Ovaj je problem postao aktualan nakon desetljeća ekonomskog rasta koji je bio vođen domaćom potražnjom uslijed velikih priljeva kapitala u mnoga periferna gospodarstva Europe. Priljev kapitala vodio je stvaranju velikih balona na tržištu stanova i doveo je do ekspanzije u tim zemljama. Ekspanzija je dovela do porasta troškova i cijena, koje su rasle znatno više u periferiji nego u središtu. Periferne ekonomije su postajale sve manje konkurentne što je postalo problem kad je došlo do prekida dotoka kapitala. Posljedica je bio snažan pad ekonomske aktivnosti što je dovelo do gubitka domaće potražnje, ali je zbog gubitka konkurentnosti inozemna pozicija ostala i dalje slaba. Problem je postao veći kada su smanjeni prihodi i očekivanja o dugotrajnoj gospodarskoj slabosti dovela do snažnih proračunskih deficita. Zbog panike na tržištu obveznica, središte Eurozone je tražilo snažne programe štednje. Štednja je dovela do još dubljeg pada gospodarstava periferije što je, bez ekspanzije u jezgri, rezultiralo snažnim padom u ukupnom europskom gospodarstvu. Rigidnosti na tržištu rada, loše poslovno okruženje i struktura domaće proizvodnje usporavaju oporavak konkurentnosti (Felipe, Kumar, 2011). Reforme na tržištima rada i proizvoda povećavaju mobilnost proizvodnih faktora poboljšavajući njihovu alokaciju. Reforme na financijskom tržištu poboljšavaju vanjsku konkurentnosti zbog veće konkurencije i daljnje integracije u EU. Glavni cilj projekta je pokazati da su strukturne reforme nužne kako bi se olakšala prilagodba plaća i poboljšalo poslovno okruženje (Orszaghova et. al, 2013). Projekt će uzeti u obzir i da se vanjska konkurentnost može objasniti kao dokaz visoke produktivnosti poduzeća. Ciljevi projekta će biti postignuti kroz implementaciju odgovarajućih ekonometrijskih tehnika. Projekt može pomoći poboljšanju vanjske konkurentnost i ukupne ekonomske aktivnosti u zemljama EU.]]></summary_hr><summary_en><![CDATA[The aim of project is to analyse the effects of structural reforms on external competitiveness in EU countries. This issue became important after a decade of economic growth driven through domestic demand fuelled by huge flows of capital to many european pheriphery. These capital flows fed huge housing bubbles and created booms in the countries receiving the inflows. The booms caused the rise of costs and prices much more in the periphery than in the core. Peripheral economies became increasingly uncompetitive, which was a problem once the capital inflows stopped. The result was slumps in the periphery, which lost a lot of internal demand but remained weak on the external side thanks to the loss of competitiveness. The problem was greatly exacerbated when the combination of slumping revenues and the prospect of protracted economic weakness led to large budget deficits. There was panic in the bond market and the EU core demanded harsh austerity programs. Austerity led to much deeper slumps in the periphery and without expansion in the core, the result was in fact a slump for the EU economy as a whole. Labor market rigidities, weak business environment and structure of domestic production make competition recovery sluggish (Felipe, Kumar, 2011). Labor and product market reforms increase the mobility of production factors improving their allocation in the economy. Financial market reforms boost competiveness as a consequence of higher competition and further integration in EU. The main goal of the project is to show that reforms in these areas are needed to facilitate wage adjustment and improve the business environment (Orszaghova et. al, 2013). The project takes into account that external competitiveness can be explained as an expression of high ?rm-level productivity. Projects goals will be achieved through implementation of appropriate econometrics techniques. This project can help to improve external competitiveness and overall economic activity in EU countries.]]></summary_en></project><project>
<id>3544</id><title_hr><![CDATA[Štetni učinci pojedinačnih i kombiniranih mikotoksina Aspergillus vrsta]]></title_hr><title_en><![CDATA[Adverse effects of single and combined mycotoxins produced by Aspergilli]]></title_en><user_id>12487</user_id><user_firstLast_name>Maja Šegvic Klarić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-5982</code><acronim><![CDATA[MycotoxA]]></acronim><duration>08.02.2016 - 07.12.2020</duration><status>Završio</status><financ_value>132.693,87 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Javno zdravstvo i zdravstvena zaštita, Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Public health and health services, Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Farmaceutsko-biokemijski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Pharmacy and Biochemistry]]></institution_en><team_members_id>12800, 1301, 13122, 13149, 343, 3520, 13379, 5026, 2516, 201, 179, 12345, </team_members_id><team_members_names><![CDATA[DANIELA JAKŠIĆ DESPOT, Ana Mornar Turk, Biljana Nigović, Dubravko Jelić, Dubravka Rašić, Andrea Hulina, Sándor Kocsubé, Davor Želježić, Nevenka Kopjar, Maja Peraica, Davorka Breljak, Lada Rumora, ]]></team_members_names><keywords_hr><![CDATA[Aspergillus, mikotoksini, interakcije, oksidacijski stres, genotoksičnost, imunotoksičnost]]></keywords_hr><keywords_en><![CDATA[Aspergilli, mycotoxins, interactions, oxidative stress, genotoxicity, immunotoxicity]]></keywords_en><summary_hr><![CDATA[Prema EU dokumentu o klimatskim promjenama u južnoj i jugoistočnoj Europi očekuje se povećanje temperature za 4-5° C, te sušna razdoblja u kombinaciji s velikom količinom oborina i poplave. Takve klimatske promjene  mogu se  odraziti na obrazac pojavnosti plijesni-producenata mikotoksina. Aspergillus vrste i njihovi mikotoksini mogli bi postati češći kontaminanti hrane u našem podneblju nego li je to bilo do sada, što može značajno povećati rizik za zdravlje bilo da se radi o unosu toksina ingestijom ili inhalacijom. S mikotoksikološkog stajališta, Aspergillus vrste iz sekcija Flavi, Circumdati, Nigri, Versicolores i Terrei zaslužuju  posebnu pozornost zbog proizvodnje aflatoksina B1, okratoksina A, fumonizina, sterigmatocistina i citrinina. Mehanizam toksičnosti tih mikotoksina još uvijek nije razjašnjen. Jedan od mogućih mehanizama koji igra značajnu ulogu u imunotoksičnosti, genotoksičnosti i kancerogenosti mikotoksina je oksidacijski stres. To bi se moglo spriječiti korištenjem nekih prirodnih antioksidanata kao što je resveratrol. Stoga su ciljevi ovog projekta: 1) istražiti pojavnost genotipova Aspergillus vrsta u hrani i zraku zatvorenih plijesnima opterećenih prostora, primjenom sekvenciranja ITS /CaM regije DNA; 2) ispitati toksinogenosti Aspergillus vrsta  in vitro i ex vivo pomoću tekućinske kromatografije visoke učinkovitosti u kombinaciji s masenom spektrometrijom; 3) razjasniti ulogu oksidacijskog stresa u mehanizmu toksičnosti mikotoksina in vitro / in vivo određivanjem lipidne peroksidacije, staničnih antioksidanta i ekspresije proteina toplinskog šoka; 4) ispitati toksične interakcije mikotoksina (aditivnost, sinergizam, antagonizam) u dvojnim i trojnim kombinacijama koncentracija koje odgovaraju EU limitu koristeći stanične linije i statističke modele,  te 5) ispitati antioksidativni potencijal resveratrola. Rezultati će pružiti temelj za preporuke i / ili reviziju postojećih regulatornih smjernica kako bi se smanjio rizik za ljudsko zdravlje.]]></summary_hr><summary_en><![CDATA[The EU green paper on climate change in Europe foresees an increase of 4-5°C in temperature and a water availability reduction in combination with higher rainfall and floods in southern and south-eastern Europe. Such changes in climatic conditions may reflect on the food contamination pattern through mycotoxin-producing moulds. Thus, mycotoxin-producing Aspergilli may become more frequent in our region, increasing the risk of exposure to their mycotoxin mixtures in food and the air of damp dwellings. From the mycotoxicological point of view, species from sections Flavi, Circumdati, Nigri, Versicolores and Terrei require particular attention due to the production of aflatoxin B1, ochratoxin A, fumonisins, sterigmatocystin and citrinin. The mechanism of toxicity of these mycotoxins has still not been elucidated. One of the possible mechanisms that plays a significant role in the immunotoxicity, genotoxicity and carcinogenicity of mycotoxins is oxidative stress. This mechanism could be contravened by antioxidants such as resveratrol. Therefore, the objectives of this project include: 1) research on occurrence and genotyping of airborne and foodborne Aspergilli using the ITS/CaM region of DNA sequence-based analysis; 2) checking the ability of Aspergilli to produce mycotoxins in vitro and ex vivo using high performance liquid chromatography coupled with mass spectrometry; 3) clarifying the involvement of oxidative stress in the toxicity of mycotoxins in cell lines and animal model by measuring lipid peroxidation, cell antioxidants and expression of heat shock proteins; 4) estimation of mycotoxin toxic interactions (additivity, synergism, antagonism) in binary and tertiary combinations at their EU regulatory limits using cell lines and statistical models, and 5) evaluation of resveratrol protection from oxidative stress. Our results will provide the base for recommendations and/or revision of current regulatory guidelines in order to minimize risks for human health.]]></summary_en></project><project>
<id>3550</id><title_hr><![CDATA[Od prašuma do oranica: povijest antropizacije šuma u Slavoniji od srednjeg vijeka do početka 20. stoljeća]]></title_hr><title_en><![CDATA[From Virgin Forests to Ploughlands: History of Anthropisation of Forests in Slavonia from the Middle Ages to the Beginning of the 20th Century]]></title_en><user_id>1311</user_id><user_firstLast_name>Robert Skenderović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-6719</code><acronim><![CDATA[FVTPHOAFS]]></acronim><duration>01.06.2015 - 31.05.2019</duration><status>Završio</status><financ_value>59.645,63 eur</financ_value><scie_area_hr>Humanističke znanosti, Biotehničke znanosti, </scie_area_hr><scie_area_en>Humanities, Biotechnical sciences, </scie_area_en><scie_field_hr>Povijest, Šumarstvo, Drvna tehnologija, </scie_field_hr><scie_field_en>History, Forestry, Wood technology, </scie_field_en><institution_hr><![CDATA[Hrvatski institut za povijest]]></institution_hr><institution_en><![CDATA[Croatian Institute of History]]></institution_en><team_members_id>783, 5743, 13381, 7174, 1164, 4458, 23208, </team_members_id><team_members_names><![CDATA[Stanko Andrić, Karlo Beljan, Krunoslav Teslak, Anđelko Vlašić, Milan Vrbanus, Dinko Župan, Josip  Parat, ]]></team_members_names><keywords_hr><![CDATA[povijest šuma, Slavonija, antropizacija, modernizacija, održiv razvoj]]></keywords_hr><keywords_en><![CDATA[history of forests, Slavonia, anthropisation, modernisation, sustainable development]]></keywords_en><summary_hr><![CDATA[Šume predstavljaju jedno od najvažnijih prirodnih bogatstava Slavonije. Zadatak je predloženog projekta utvrditi razmjere čovjekova utjecaja na slavonske šume u razdoblju od srednjeg vijeka do početka 20. stoljeća, te utvrditi važnost i nužnost toga procesa za opću modernizaciju Slavonije, pogotovo u vrijeme izrazite industrijalizacije i urbanizacije u 19. stoljeću. Središnji cilj projekta je odgovoriti na pitanje koliki su šume stvarno bile kapital u gospodarskom smislu, tko je tim kapitalom raspolagao i kako je taj kapital ulagan u javno dobro, odnosno kako je pretvaran u društveni i kulturni kapital. Projekt će rezultirati s  web stranicom s interaktivnom kartom šumskih prostora, radionicom o povijesnim izvorima, knjigom izabranih povijesnih izvora, znanstvenim skupom, zbornikom radova znanstvenog skupa, knjigom grupe autora o antropizaciji šuma u Slavoniji te nizom znanstvenih radova u domaćim i svjetskim publikacijama. ]]></summary_hr><summary_en><![CDATA[The forests are among the greatest natural riches of Slavonia. This project aims to determine the extent of human influence on the Slavonian forests from the Middle Ages to the beginning of the 20th century, and to determine the importance and essentiality of this process for the modernisation of Slavonian region, especially during the period of increasing industrialisation and urbanisation in the 19th century. The main objective of the project is to answer questions how important an economic asset they were, who owned and exploited this asset and how it was invested in the public good, that is, how it was transformed into the social and cultural capital.The results will be achieved through the following activities: creating the website with an interactive map of forest complexes, organising the workshop on the historical sources, publishing the book with a selection of sources relevant to the history of forests, organising the conference, publishing the book of conference proceedings, and, finally, publishing the collaborative monograph on the anthropisation of the forests in Slavonia, as well as a series works in domestic and foreign journals.]]></summary_en></project><project>
<id>3553</id><title_hr><![CDATA[Dijalektološka i jezičnopovijesna istraživanja hrvatskoga jezika]]></title_hr><title_en><![CDATA[Researches in dialectlology and history of the Croatian language]]></title_en><user_id>13675</user_id><user_firstLast_name>Josip Lisac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-1946</code><acronim><![CDATA[DJIH]]></acronim><duration>01.05.2015 - 30.04.2019</duration><status>Završio</status><financ_value>29.796,27 eur</financ_value><scie_area_hr>Humanističke znanosti, Društvene znanosti, </scie_area_hr><scie_area_en>Humanities, Social sciences, </scie_area_en><scie_field_hr>Filologija, Sociologija, Psihologija, Povijest, Etnologija i antropologija, Kroatologija, </scie_field_hr><scie_field_en>Philology, Sociology, Psychology, History, Ethnology and anthropology, Croatology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zadru]]></institution_hr><institution_en><![CDATA[University of Zadar]]></institution_en><team_members_id>13304, 12688, 13434, 13146, </team_members_id><team_members_names><![CDATA[Lina Pliško, Marijana Tomelić Ćurlin, Marijana Fabijanić, Josip Galić, ]]></team_members_names><keywords_hr><![CDATA[dijalekt, književnost, kodeks, narječje, romanizam]]></keywords_hr><keywords_en><![CDATA[dialect, literature, codex, group of dialects, romance loanwords]]></keywords_en><summary_hr><![CDATA[Znanstveni projekt „Dijalektološka i jezičnopovijesna istrživanja hrvatskoga jezika“ (DJIH) obrađuje dvije strane medalje hrvatskoga jezika, dijalektološku i jezičnopovijesnu.  To znači da obrađuje suvremeno hrvatsko dijalekatno stanje organskih idioma i genezu hrvatskih narječja, s jedne strane, i hrvatsku jezičnu baštinu kako je ona zapisana u književnim djelima i u drugim jezičnim spomenicima, s druge strane. Očekuje se da će projekt rezultirati znanstvenim rezulatima velike važnosti. Riječ je prvenstveno o sedam monografija iz pera petero istraživača, a zatim i o  drugim prinosima. Svi ti prinosi obogaćivat će poznavanje hrvatskoga jezika od Istre do Dubrovnika i od Gorskoga kotara do zapadnoga Srijema, kao i svagdje drugdje gdje ima hrvatskih govornika ili ih je bilo u prošlosti. Može se očekivati da će projekt u znatnoj mjeri unaprijediti hrvatsku genetsku lingvistiku, prije svega proučavanje kajkavskoga i čakavskoga narječja, a zatim i hrvatske dijalektologije u cjelini. To znači da će u punoj mjeri biti obuhvaćeni i govori štokavskoga narječja, kao i idiomi torlačkoga narječja kojima govore Hrvati. Posebno je važno da će rad na projektu bitno unaprijediti kvalitetu istraživanja svih angažiranih znanstvenika, naročito onih najmlađih. Donijet će ne samo činjenične novosti u hrvatsku genetsku lingvistiku, on će biti i zametak planiranoga Centra za hrvatsku dijalektologiju pri Sveučilištu u Zadru.]]></summary_hr><summary_en><![CDATA[Scientific project „Researches on dialectology and history of the Croatian language“ (DJIH) deals with two sides of the medal of the Croatian language, its dialectological side and the side of its linguistic history. It means that the project discusses contemporary Croatian dialectal situation of organic idioms  and the genesis of Croatian dialects, on one side, and the Croatian linguistic heritage as written (recorded) in literary works and other linguistic monuments, on the other side. It is expected that the project will offer scientific results of great importance. They mainly refer to seven monographs written by five authors, and to other contributions, too. All those contributions will enrich the (present) knowledge about the Croatian language from Istria to Dubrovnik and from Gorski kotar to the western part of Srijem, as well as elsewhere, i. e. in the areas where the Croatian speaking population is present or was present in the past. It could be expected that the project would improve the Croatian genetic linguistics, first of all the study of the Kajkavian and Čakavian dialect, and then the Croatian dialectology as a whole. It means that speeches of the Štokavian dialect will also be entirely included in the research, as well as the idioms of the Torlakian dialect spoken by Croats. It is particularly important that the work on this project will considerably improve the quality of scientific activity of each scientist engaged in this project (member of this project team), particularly of junior researchers.  Thanks to this project not only new facts will be available, but it will also serve as a basis for a future Centre for Croatian dialectology, (planned to be founded) at the University of Zadar. ]]></summary_en></project><project>
<id>3556</id><title_hr><![CDATA[Zelena  otapala  za  zelene  tehnologije]]></title_hr><title_en><![CDATA[Green Solvents for Green Technologies]]></title_en><user_id>3228</user_id><user_firstLast_name>Ivana Radojčić Redovniković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-9550</code><acronim><![CDATA[GREEN]]></acronim><duration>01.09.2015 - 31.08.2018</duration><status>Završio</status><financ_value>78.412,24 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Biotehnologija, Prehrambena tehnologija, </scie_field_hr><scie_field_en>Biotechnology, Food technology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Food Technology and Biotechnology]]></institution_en><team_members_id>5279, 6224, 13472, 6458, 6482, 5443, 6126, 13471, 3968, 13470, 18925, 18926, 21346, </team_members_id><team_members_names><![CDATA[Višnja Gaurina Srček, Karin Kovačević Ganić, Dubravka Škevin, Aleksandra Sander, Jasna Prlić Kardum, Kristina  Radošević, Marina Cvjetko Bubalo, Klara Kraljic, Jasna Halambek, Marko Obranović, Anamarija Mitar, Kristina  Zagajski Kučan, Manuela  Panić, ]]></team_members_names><keywords_hr><![CDATA[biokataliza, biološkiaktivni spojevi, eutektična  otapala, ionske kapljevine, pročišćavanje tekućih goriva]]></keywords_hr><keywords_en><![CDATA[biocatalysis, biologically active compounds, deep euectic solvents, fuel purification, ionic liquids]]></keywords_en><summary_hr><![CDATA[Posljednjih su nekoliko godina globalna ekonomska kriza,rastuće cijene hrane, energije i drugih roba te povećana svijesto utjecaju čovjeka na okoliš potaknuli koncept zelene ekonomijeu središte političkih, gospodarskih i znanstvenih rasprava. Uskladu s time ionske kapljevine i eutektična otapala intenzivnose istražuju s ekološkog, tehnološkog i ekonomskog gledištakao zamjena za tradicionalna organska otapala. Ciljpredloženog Projekta jest stjecanje znanja o prirodnim ionskimkapljevinama i eutektičnim otapalima dizajniranih za specifičneprocese u prehrambenoj tehnologiji, biotehnologiji i kemijskojtehnologiji. U sklopu Projekta pripravit će se ionske kapljevine ieutektična otapala iz prirodnih sirovina poput kolinijevih soli,ugljikohidrata, organskih kiselina i aminokiselina, odreditinjihova fizikalno-kemijska svojstva i toksičnost te primjeniti kaootapala u ekstrakciji biološki aktivnih spojeva iz nusproizvodaprehrambene industrije, biokatalitičkim reakcijama te procesupročišćavanja tekućih goriva. Prema našim saznanjima uRepublici Hrvatskoj jedina smo istraživačka grupa koja sesustavno bavi izučavanjem zelenih otapala, a što je u skladu sključnim ciljevima EU vezanim uz očuvanje okoliša. S tim u svezi,financiranje ovog projekta iznimno je važno za nastavak našegmultidisciplinarnog istraživanja zelenih otapala (priprava,karakterizacija i primjena) što je također od velikog interesa i zahrvatsku akademsku zajednicu. Provedbom predloženogProjekta profilirat ćemo se u vodeću grupu u područjuistraživanja prirodnih ionskih kapljevina i eutektičnih otapala, nesamo u RH već i u inozemstvu. Također, stečeno znanje moćićemo prenijeti zainteresiranim industrijskim parterima kako biimplementirali zelena otapala u postojeće i/ili nove procese.]]></summary_hr><summary_en><![CDATA[Global economic crisis, soaring commodity prices and growingawareness of humanity&#39;s impact on the environment havepushed the “green economy” concept into mainstream policydebate in recent years. Accordingly, as a promising alternativeto traditional organic solvents from both the environmental andtechnological perspectives, neoteric solvents (neoteric = new,recent, modern), ionic liquids (ILs) and deep eutectic solvents(DESs), have been dramatically expanding in popularity as anew generation of designer solvents with possible applicationsin various industrial fields. The aim of proposed Project is to gainan in-depth understanding of the natural ILs and DESs withfine-tuned properties, as well as to implement these solventsinto food technology, biotechnology and chemical technology. Within the Project ILs and DESs, based on renewable sourcessuch as cholinium salts, sugars, organic acids and amino acids,will be prepared and characterized, followed by examination oftheir applicability as solvents for extraction of phenoliccompounds from wine and oil by-product, in biocatalyticreactions and in fuel purification process. To our knowledge, inthe Republic of Croatia we are the only research group involvedin multidisciplinary and systematic approach in the investigationof ILs and DESs. Thus, proposed Project would enable ourfurther research in the field of preparation, characterization andapplication of these new green solvents, which is of greatimportance for Croatian academic community in order tosuccessfully follow the EU directives. Additionally, knowledgegained through proposed Project will profile us as the leadinggroup in the field of natural ILs and DESs research, both in theRepublic of Croatia and EU, for fostering knowledge transfer toacademia and potential industry partners. ]]></summary_en></project><project>
<id>3561</id><title_hr><![CDATA[Utjecaj deformacija od puzanja na nosivost čeličnih i aluminijskih stupova pri djelovanju požara]]></title_hr><title_en><![CDATA[Influence of creep strain on the load capacity of steel and aluminium columns exposed to fire]]></title_en><user_id>11212</user_id><user_firstLast_name>Neno Torić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2014-09</proposal_call><code>UIP-2014-09-5711</code><acronim><![CDATA[Column creep]]></acronim><duration>01.10.2015 - 30.09.2018</duration><status>Završio</status><financ_value>108.368,17 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Građevinarstvo, </scie_field_hr><scie_field_en>Civil engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu Fakultet građevinarstva, arhitekture i geodezije]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Civil Engineering, Architecture and Geodesy]]></institution_en><team_members_id>13198, 7970, 13185, 13099, 13156, 13226, </team_members_id><team_members_names><![CDATA[Ian Burgess, Bernardin Peroš, Alen Harapin, IVICA BOKO, Ivana Uzelac, Vladimir Divić, ]]></team_members_names><keywords_hr><![CDATA[čelik, aluminij, požar, puzanje, reološki model, analitički model, stupovi, epruvete]]></keywords_hr><keywords_en><![CDATA[steel, aluminium, fire, creep, rheological model, analytical model, column, coupon]]></keywords_en><summary_hr><![CDATA[Deformacija od puzanja pri visokim temperaturama predstavlja jedan od značajnih čimbenika u odgovoru čeličnih i aluminijskih konstrukcija u ekstremnim uvjetima pri djelovanju požara. Svrha ovog projekta jest iznalaženje novih modela puzanja koji su primjenjivi za aktualno korištene slitine čelika i aluminija kao i analiza utjecaja puzanja na čelične i aluminijske stupove koji predstavljaju najosjetljiviji dio nosive konstrukcije s aspekta kolapsa. Projekt u početnom stadiju obuhvaća eksperimentalno određivanje stacionarnih krivulja puzanja čelika i aluminija koje su određene na nizu nivoa temperature i naprezanja u svrhu određivanja adekvatnih analitičkih/reoloških modela puzanja. Potom se planira implementacija dobivenih modela puzanja u istraživačke kodove razvijene na ustanovi voditelja projekta kao i na ustanovi vanjskog suradnika kojim bi se numerički opisalo ponašanje čeličnih i aluminijskih stupova uslijed djelovanja puzanja. Sljedeći stadij projekta odnosi se na provođenje eksperimentalnog istraživanja koje uključuje ispitivanje čeličnih i aluminijskih stupova izloženih različitim nivoima opterećenja kao i specifičnim temperaturnim krivuljama koje bi inducirale razvoj deformacija od puzanja u stupovima. U posljednjem stadiju projekta izvršila bi se verifikacija dobivenih modela puzanja nad dobivenim rezultatima ispitivanja stupova. Ispitivanjem čeličnih i aluminijskih stupova dobio bi se uvid u ponašanje stupova uslijed razvoja deformacija od puzanja kao i uvid koji temperaturni scenario uzrokuje značajan razvoj navedenih deformacija. Zaključci dobiveni na temelju opisanih eksperimenata koristili bi se i za unaprjeđenje pravila projektiranja čeličnih i aluminijskih konstrukcija u požaru.]]></summary_hr><summary_en><![CDATA[High temperature creep represents one of the important factors influencing the response of steel and aluminium structures during fire exposure. The purpose of the project is to develop new types of creep models applicable to new types of steel and aluminium alloys and to conduct the analysis of the influence of creep strain on the behaviour of steel and aluminium columns, which represent the most sensitive parts of the whole structure during collapse stage. The initial stage of the project covers conducting tests for determining stationary creep curves.  The curves would be obtained on different temperature and stress levels with the purpose of creating new types of analytical/rheological creep models.   The developed creep models are intended to be implemented into two research codes developed by the PI&#39;s host institution and by the institution of the external member of the project team. The codes will subsequently be used for numerical modelling of the behaviour of steel and aluminium columns influenced by creep. Following the implementation of the creep models, fire tests which cover testing of steel and aluminium columns exposed to different load and temperature levels are planned, including transient heating curves which would induce significant development of creep strain in the columns. In the final stage of the project verification of the developed creep models is planned using columns’ fire test results. A new insight into the behaviour of steel and aluminium columns under creep influence would be obtained including the insight into types of fire heating scenarios causing a significant increase of creep strain. Conclusions obtained on the basis of the performed tests would be suitable for creating new set of design rules for steel and aluminium structures in fire. ]]></summary_en></project><project>
<id>3567</id><title_hr><![CDATA[Uloga upale u razvoju zloćudnog tumora mokraćnog mjehura]]></title_hr><title_en><![CDATA[Role of inflammation in bladder cancer pathogenesis]]></title_en><user_id>5769</user_id><user_firstLast_name>Janoš  Terzić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-1904</code><acronim><![CDATA[iBC]]></acronim><duration>28.10.2015 - 27.10.2019</duration><status>Završio</status><financ_value>124.493,99 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Split School of Medicine]]></institution_en><team_members_id>3080, 5640, 5111, 7062, 4462, 13754, 19132, </team_members_id><team_members_names><![CDATA[Viljemka Bučević Popović, Marina Degoricija, Jelena Korać Prlić, Sergei Grivennikov, Marijan Šitum, Boris Mihaljevic, Maria Bošković, ]]></team_members_names><keywords_hr><![CDATA[mokraćni mjehur, rak, upala, mikrobiom, STAT3, IL-6]]></keywords_hr><keywords_en><![CDATA[bladder, cancer, inflammation, microbiome, STAT3, IL-6]]></keywords_en><summary_hr><![CDATA[Oko 20% smrtnih slučajeva od zloćudnih tumora posljedica je kronične upale. Virusne i bakterijske infekcije, infestacije parazitima, autoimunost i iritirajuće kemikalije uzrokuju upalne promjene koje stimuliraju začetak zloćudnih tumora, njihov ras i metastaziranje. Drugi istraživači i mi smo pokazali da su ključne molekularne poveznice između kronične upale i zloćudnih tumora citokin IL-6 i transkripcijski čimbenik STAT3. Postaje sve očitije da i mikrobni sastav pojedinog tkiva ima važnu ulogu u razvoju kronične upale i zloćudnih tumora. Uloga upale u patogenezi zloćudnih tumora mokraćnog mjehura (TMM) slabo je proučena iako upala izazvana sa Schistosoma haematobium potiče razvoj TMM, dok se upala uzrokovana s BCG uspješno koristi za njegovo liječenje.Za pročavanje upale u razvoju TMM koristiti ćemo najmodernije mišje modele (tzv. knock-out miševe) koijma će tumori biti inicirati s BBN-om. Analizirati ćemo: (1) ulogu IL-6 i (2) ulogu STAT3 u razvoju TMM kao i (3) terapijski potencijal STAT3 inhibitora. Nadalje planiramo (4) proučavati važnosti mikrobioma u nastanku TMM koristeći mišji model te bolesti uz upotrebu antibiotika koji će promijeniti sastav mikrobioma. Proučavajući (5) mikrobiomski sastav urina osoba s TMM i zdravih jedinki pokušati ćemo povezati određene mikrobe s TMM. Projekt proučava temeljne odlike zloćudnih tumora mokraćnog mjehura pa ukoliko se pokaže da smanjivanje aktivnosti STAT3 usporava razvoj TMM naši rezultati mogu potaknuti stvaranje novih lijekova (inhibitora STAT3) za TMM. Rezultati proučavanja mikrobioma mogu dovesti do novih preventivinih mjera (razvoja cjepiva ili upotrebe antibiotika). Kako je TMM sedmi tumor po učestalosti predloženi projekt je od velikog medicinskog, socijalnog i ekonomskog značaja. Članovi projektnog tima su iskusni istraživači su kao ključni znanstvenici objavljivali otkrića u najboljim časopisima poput Cancer Cell i Nature Genetics, što jamči uspješnu realizaciju projekta. ]]></summary_hr><summary_en><![CDATA[Around 20% of cancer deaths are a consequence of chronic inflammation. Viral and bacterial infections, parasitic infestation, autoimmunity or chemical irritants cause inflammatory changes that stimulate cancer initiation, promotion and metastasis. We and others have shown that main molecular links between inflammation and cancer are cytokine IL-6 and its transcription factor STAT3. It is becoming obvious that microbiome composition of particular niche is important element of inflammation and cancer development. The role of inflammation in urinary bladder cancer (BC) pathogenesis is poorly understood although chronic inflammation caused by Schistosoma haematobioum has pro-tumorigenic effect while acute inflammation caused by BCG is successfully used as a therapy for BC. To investigate the role of inflammation in BC development we will use BBN induced BC mice models and will study: (1) the role of IL-6 (by using IL-6 KO mice); (2) the role of STAT3 by assessing its targeted deletion in mice urothelium and (3) therapeutic potential of STAT3 inhibitor. Additionally, we plan to (4) test importance of microbiome in BC development by using mice BC model and antibiotic treatment to manipulate bladder microbiome composition and to (5) analyze human bladder cancer microbiome, in order to associate BC with specific microbiota.This project addresses fundamental questions of bladder cancerogensis. If altering STAT3 activity has inhibitory effect on BC development that finding can lead to new therapies (use of STAT3 inhibitors) for established BC. Findings generated by the microbiome analysis can lead to novel preventive measures (microbiota manipulation by antibiotics or vaccination). Team members are experienced scientist with publications in Cancer Cell and Nature Genetics which is securing successful realization of the project. Because BC is the seventh most common malignancy, proposed project is of great medical, social and economic importance.]]></summary_en></project><project>
<id>3569</id><title_hr><![CDATA[Repeticije višeg reda i globalna repeticijska mapa za genome neandertalca, čovjeka i čimpanze]]></title_hr><title_en><![CDATA[Higher order repeats and global repeat map for neandertal, human and chimpanzee genomes]]></title_en><user_id>5102</user_id><user_firstLast_name>Vladimir Paar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-3626</code><acronim><![CDATA[NEAND_HUMAN_CHIMP]]></acronim><duration>01.06.2015 - 31.05.2019</duration><status>Završio</status><financ_value>88.526,11 eur</financ_value><scie_area_hr>Prirodne znanosti, Biomedicina i zdravstvo, </scie_area_hr><scie_area_en>Natural sciences, Biomedicine and health sciences, </scie_area_en><scie_field_hr>Biologija, Matematika, Fizika, Kemija, </scie_field_hr><scie_field_en>Biology, Mathematics, Physics, Chemistry, </scie_field_en><institution_hr><![CDATA[Hrvatska akademija znanosti i umjetnosti]]></institution_hr><institution_en><![CDATA[Croatian Academy of Sciences and Arts]]></institution_en><team_members_id>4004, 5356, 5282, 19031, </team_members_id><team_members_names><![CDATA[Matko Glunčić, Ines Vlahović, Marija Rosandić Pilaš, Ivica Martinjak, ]]></team_members_names><keywords_hr><![CDATA[nekodirajuća DNK, genomski regulatori, repeticije višeg reda, globalna repeticijska mapa, genom čovjeka, genom čimpanze, genom neandertalca]]></keywords_hr><keywords_en><![CDATA[noncoding DNA, genomic regulators, higher order repeats, global repeat map, human genome, chimpanzee genome, neandertal genome, biological evolution]]></keywords_en><summary_hr><![CDATA[Istraživanje nekodirajuće DNA postaje bitno pitanje genomike zbog ključne uloge kao regulatora. Zato raste interes za primarne repeticije i repeticije višeg reda, s osobitom važnošću u medicini i evoluciji. Glavni cilj projekta je vrhunska identifikacija i opsežna mapa repeticija višeg reda (HOR) primjenom našeg originalnog izuzetno efikasnog i robusnog algoritma Globalne repeticijske mape (GRM) na genome neandertalca (nedavno sekvencioniran na Max Planck Inst. Evol. Anthropol. u Leipzigu) i čovjeka i čimpanze (iz datoteke NCBI, Bethesda). GRM algoritam temeljen je na novom matematičkom konceptu kompletnog ansambla stringova  Analizom repeticija može se dobiti uvid o evoluciji tih dinamički promjenjivih struktura čime GRM metoda postaje konkurentna na svjetskoj razini . Naši publicirani rezultati za egzemplarne slučajeve (&#39;&#39;case study&#39;&#39;) i inicijalne pilot studije su ohrabrujuće. Interdisciplinarni znanstveni ciljevi postići će se na dodiru genomike, bioinformatike, matematike, nelineane dinamike i naprednog računarstva. Za potrebe računanja na velikoj skali razvit ćemo naprednu verziju GRM programa primjenjivu u okružju cluster, grid i cloud kompjutinga. Ishodi projekta uključit će slobodni Katalog Globalnih Repeticijskih Mapa za HOR-ove triju primata (&#39;&#39;web based data based service&#39;&#39;), naprednu GRM verziju za korisnike, i radionice za trening stranih i domaćih mladih znanstvenika za korištenje naprednog GRM kompjutinga koji pruža superiorne mogućnosti primjene. GRM metoda u dosad istraženim slučajevima otkriva po prvi put u svijetu nove značajne korelacije koje se dosad nisu mogle otkriti postojećim algoritmima. Planirana je ativnost za povećanje vidljivosti ovih istraživanja i podstiče diseminacija jedinstvenih rezultata u međunarodnoj znanstvenoj zajednici, uključujući publiciranje u renomiranim međunarodnim časopisima, sudjelovanje na međunarodnim skupovima, i podsticanja međunarodne znanstvene suradnje.]]></summary_hr><summary_en><![CDATA[One of the key questions of modern genomics is the investigation of noncoding DNA because of possible important role as regulators. Thus of importance are complex repeats and higher order repeats, with potential significance in medicine and biological evolution. The main objective of the project includes the state-of-the-art identification of comprehensive map of higher order repeats (HORs), using our Global Repeat Map (GRM) algorithm for neandertal and NCBI assemblies of human and chimpanzee genomes. It will be of significant interest to discover how these dynamically changeable structures evolved, by analysis and comparison of similar repeats. Our initial published results and pilot studies are encouraging. The interdisciplinary scientific objectives will be achieved at interface between genomics, bioinformatics, mathematical methods, nonlinear dynamics and advanced scientific computing. For the need of large-scale studies in this project we will develop advanced version of our GRM program applicable on the environment of advanced computing and distributed calculations in cluster, grid and cloud cmputing at the Faculty of Science. Major project outcomes include free Catalogue of Global Repeat Maps for HORs with large secondary repeat units of three specieses (web-based database service), novel advanced GRM version for users and workshops for training foreign and domestic young researchers in the use of advanced GRM. Including M.Sc. and Ph.D students as co-workers will contribute to training of researchers in the early stages of research career and support transfer of know-how in the frontier of of computing methods. Activities are planned to increase visibility of the ongoing research and support dissemination of results to the international research community, including publications in international journals, contributions to international workshops and conferences, inviting guest scientists from abroad and initiating new international collaborations.]]></summary_en></project><project>
<id>3571</id><title_hr><![CDATA[Pametna okruženja za poboljšanje kvalitete života]]></title_hr><title_en><![CDATA[ELISE: Easy Living in Smart Environments]]></title_en><user_id>3685</user_id><user_firstLast_name>Mladen Russo</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2014-09</proposal_call><code>UIP-2014-09-3875</code><acronim><![CDATA[ELISE]]></acronim><duration>01.10.2015 - 30.09.2018</duration><status>Završio</status><financ_value>66.228,68 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, Elektrotehnika, </scie_field_hr><scie_field_en>Computer sciences, Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Fakultet elektrotehnike, strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Electrical Engineering, Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>7617, 7602, 7558, 7480, 20692, 21298, 18942, </team_members_id><team_members_names><![CDATA[Maja Stella, Matko Šarić, Marjan Sikora, Milan Ramljak, Ante Topić, Luka Kraljević, Goran Udovičić, ]]></team_members_names><keywords_hr><![CDATA[pametne okoline, nosiva sučeljam računalni vid, proširena stvarnost, prepoznavanje govora, prikupljanje energije iz okoline, lokalizacija, zv. kulise]]></keywords_hr><keywords_en><![CDATA[smart environments, wearable interfaces, computer vision, augmented reality, speech recognition, ambient energy harvesting, localization, soundscaping]]></keywords_en><summary_hr><![CDATA[Pametna okolina predstavlja svijet pun različitih senzora i pametnih uređaja koji neprimjetno rade skupa, čineći svakodnevni život lakšim i udobnijim. Projekt ELISE je zamišljen kao interdisciplinarni istraživački pristup usmjeren ka poboljšanju tehnologija na kojima se temelje pametne okoline, s ciljem uspostavljanja okvira za razvoj raznih real-life usluga i aplikacija u pametnim okolinama. Glavna područja istraživanja će uključivati senzore niske potrošnje i prikupljanje energije iz okoline, nosiva sučelja, prepoznavanje govora, računalni vid, prepoznavanje objekata i teksta, proširenu stvarnost, lokalizacijske tehnologije, zvučne kulise i auralizaciju. Svi članovi našeg interdisciplinarnog tima su visoko kvalificirani stručnjaci u tim područjima, budući da su već objavili doktorske disertacije i visoko kvalitetne radove u predloženim područjima istraživanja. Projekt će također doprinijeti obuci dva nova doktoranda omogućujući im odlične uvjete za njihova istraživanja. Istraživanja u svim područjima će se temeljiti na integriranom pristupu s vizijom razvoja real-life aplikacija u pametnoj okolini. Osobito dvije aplikacije će usmjeravati naš rad, te su planirane za izradu prototipa i demonstraciju u posljednjim fazama projekta: Smart sightseeing (Pametno razgledavanje) i Smart museum tour (Pametna tura muzejom). Temeljit će se na sučelju proširene stvarnosti (Augmented Reality – AR) na način da će se objekti od interesa automatski prepoznavati te omogućiti predstavljanje dodatnih sadržaju korisniku, također će biti opremljeni modulom za lokalizaciju, imati mogućnost poboljšanja AR pomoću zvučnih kulisa, biti upravljani pomoću govora i pametnih nosivih sučelja, npr. sučelje za prepoznavanje pokreta ruku, uz sposobnost detektiranja korisnikovih emocionalnih stanja i prilagođavanja sadržaja sukladno tome. Razvijeni moduli također će tvoriti osnovu za razvoj drugih aplikacija za lakši život u pametnim okolinama, uključujući domove, bolnice, ustanove za brigu o starijima i nemoćnima, uredima, gradovima...]]></summary_hr><summary_en><![CDATA[Smart environment represents a world full of different sensors and smart devices seamlessly working together, making everyday living easier and more comfortable. ELISE is envisioned as an interdisciplinary research approach aimed for improving the technologies on which smart environments are based, with the goal of establishing a framework for developing various real-life services and applications in smart environments. Primary areas of research will include low power sensing and ambient energy harvesting, wearable interfaces, speech recognition, computer vision, object and text recognition, augmented reality, localization technologies, soundscaping and auralization. All members of our interdisciplinary team have skills and experience in these areas since their PhD theses and published papers are directly related to the proposed research. ELISE will also contribute to the training of two new PhD students providing excellent conditions for their research. Research in all areas will be based on integrated approach with a vision of developing real-life smart environment applications. Particularly two applications will drive our work and are planned for prototyping and demonstration in the last stages of the project: smart sightseeing and smart museum tour. They will be based on augmented reality interface in a way that objects of interest are recognized in the scenes enabling presentation of additional content to the user, they will be equipped will localization module, have the ability of soundscape to enhance AR, be controlled via speech and wearable smart interfaces, e.g. hand gesture recognition interface, with the ability of detecting user&#39;s emotional states and adapting the content accordingly. Developed modules will also form the basis for developing other applications for easier living in smart environments, including homes, hospitals, care facilities, offices, cities...]]></summary_en></project><project>
<id>3575</id><title_hr><![CDATA[Istraživanje unosa joda u trudnoći i djetinjstvu u svjetlu nacionalne strategije prevencije poremećaja uzrokovanih nedostatkom joda ]]></title_hr><title_en><![CDATA[Investigation of iodine intake in pregnancy and childhood in view of national strategy for prevention of iodine deficiency disorders ]]></title_en><user_id>702</user_id><user_firstLast_name>Zvonko Kusić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-6499</code><acronim><![CDATA[IPACSTOPIDD]]></acronim><duration>22.09.2015 - 21.12.2019</duration><status>Završio</status><financ_value>105.819,30 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Javno zdravstvo i zdravstvena zaštita, Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Public health and health services, Clinical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>5473, 5465, 6582, 5614, 5734, 6431, 4491, 6759, 5466, 5561, 6004, 5764, 5582, 4268, 5794, 5717, 13392, 6274, 6392, 6262, 6727, 6462, 260, 6314, 6196, 6697, 6476, 24169, 23652, </team_members_id><team_members_names><![CDATA[Tomislav Jukić, Josip Stanicic, Vesna Jureša, Roko Granić, Neven Mateša, Vera Musil, Marjeta Majer, MARINA PRPIĆ, MARIJA PUNDA, Nina Dabelić, Krunoslav Kuna, Dražena Krilić, Petra Petranović Ovčariček, Željka  Bukovec Megla, Valentina Vidranski, Maja Franceschi, ORJENA ŽAJA, Zlatko Topalović, Marijan Katalenić, Milan Vrkljan, Vedrana Gladić Nenadić, Ivan Mihaljević, ANA BARIĆ, Gordana Stipančić, Boris Bonefačić, Ivan Jakšić, Križo Katinić, Marija Bosak Butković, Ivan Blažeković, ]]></team_members_names><keywords_hr><![CDATA[unos joda, trudnice, djeca, jodiranje soli, prevencija, štitnjača]]></keywords_hr><keywords_en><![CDATA[iodine intake, pregnant women, schoolchildren, salt iodination, prevention, thyroid]]></keywords_en><summary_hr><![CDATA[Dostatan unos joda je od neprocjenjivog značaja za populaciju. Nedostatan unos joda uzrokuje brojne funkcijske i razvojne poremećaje od kojih je najvažnije zaostajanje u psihomotornom razvoju. Najosjetljivije skupine su trudnice i djeca. Hrvatska je u prošlosti bila područje s teškim nedostatkom joda uz pojavu kretenizma. Zbog prisutnosti blagog do umjerenog nedostatka joda, uveden je 1996. novi zakon o univerzalnom jodiranju soli (USI) s 25 mg kalij jodida po kilogramu soli, a kao rezultat, Hrvatska je postigla dostatan unos joda. Istraživanja provedena 2009. pokazala su dostatan unos joda u Hrvatskoj, ali je medijan joda u urinu školske djece bio u porastu, a granično nizak u trudnica. Istraživanjem će se procijeniti efikasnost programa USI kako bi se procijenilo je li zadovoljava potrebe za jodom u trudnica i školske djece. Pretpostavka je da program USI u Hrvatskoj zadovoljava potrebe za jodom u trudnica i djece, ali ne i u trudnica s ograničenim unosom soli. Istraživanjem će se obuhvatiti 1000 školske djece i 500 trudnica iz četiri glavne regije Hrvatske. U djece će se mjeriti jod u urinu, volumeni štitnjače ultrazvukom, jod u soli iz kućanstava i provesti uputnik. U trudnica će se mjeriti jod u urinu, volumeni štitnjače ultrazvukom, slobodni tiroksin tireotropin, tireoglobulin (Tg) i tireoiodna protutijela u serumu i provesti upitnik. Trudnice će biti podijeljene u četiri skupine s obzirom na ograničenje unosa soli i korištenje jodnih preparata. Vrijednost Tg-a u serumu kao biljega unosa joda u trudnoći biti će utvrđena uz definiranje medijana Tg-a koji određuje dostatan unos joda. Procjena preparata s jodom biti će učinjena s obzirom na sadržaj joda. Rezultati istraživanja omogućit će upravljanje programom USI, objavu smjernica za korištenje jodnih preparata u trudnoći,  provođenje mjera prevencije prekomjernog unosa joda regulacijom sadržaja joda u namirnicama i dodacima prehrani i utvrditi vrijednost Tg-a kao biljega unosa joda u trudnoći.]]></summary_hr><summary_en><![CDATA[Sufficient iodine intake is of the utmost importance for the population. Iodine deficiency (ID) has many adverse effects on growth and development, the most important being mental impairment in children. The most susceptible groups include pregnant women and children. In the past, Croatia was region of severe ID with presence of cretinism. Due to persistence of mild to moderate ID, new regulation on universal salt iodination (USI) was introduced in Croatia in 1996 with 25 mg potassium iodide per kg of salt, thus reaching iodine sufficiency. Investigations performen in 2009 confirmed iodine sufficiency. However, median urinary iodine concentration (UIC) in schoolchildren has been rising, while pregnant women had borderline sufficient median UIC. The study will assess iodine intake and monitor USI program to determine whether it provides sufficient iodine intake. The hypothesis is that USI program in Croatia provides sufficient iodine intake in pregnancy and schoolchildren except for pregnant women with salt restriction. A total of 1000 schoolchildren and 500 pregnant women from four regions of Croatia will be included in the investigation. Methods in schoolchildren comprise measurements of UIC, thyroid volumes by ultrasound (Tvol), iodine content in salt and questionnaire.  Methods in pregnant women comprise measurements of UIC, Tvol, serum FT4, TSH, thyroglobulin (Tg), thyroid antibodies and questionnaire. Pregnant women will be classified into four groups according to salt restriction and consumption of iodine rich supplements. Value of serum Tg as a marker of ID in pregnancy will be determined. Evaluation of iodine rich supplements  will be performed in relation to iodine content. The results of the study would enable USI program management and publication of guidelines regarding consumption of iodine rich supplements in pregnancy and to regulate  iodine content in food and supplements as well as assess the value of Tg as a biomarker of ID in pregnancy.]]></summary_en></project><project>
<id>3647</id><title_hr><![CDATA[Utjecaj endemskog ratovanja na zdravlje kasnosrednjovjekovnih i ranonovovjekovnih populacija Hrvatske]]></title_hr><title_en><![CDATA[]]></title_en><user_id>2788</user_id><user_firstLast_name>Mario Šlaus</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-8678</code><acronim><![CDATA[Warandhealth]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Etnologija i antropologija, </scie_field_hr><scie_field_en>Ethnology and anthropology, </scie_field_en><institution_hr><![CDATA[Hrvatska akademija znanosti i umjetnosti]]></institution_hr><institution_en><![CDATA[Croatian Academy of Sciences and Arts]]></institution_en><team_members_id>19012</team_members_id><team_members_names><![CDATA[ Doktorand: Anita Adamić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[physical anthropology, bioarchaeology, paleopathology, health, war, osteological analyses, medieval period, Croatia]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Warfare has afflicted humankind throughout its history, and is a phenomenon that still fundamentally affects the modern world. Despite the fact that violence -related mortality is profoundly undercounted, violent conflict represents the third most important source of mortality around the world. Analyzing the effects that war had on health through the deep time perspective that archaeological investigations afford can provide unique data on the interactions between warfare, health and the environment and provided conclusions that are particularly relevant to disadvantaged communities throughout the developing world where most wars are currently being fought. This project assembles an international and multidisciplinary team of collaborators to conduct bioarchaeological investigations on two large composite skeletal samples from Croatia. The two composite series represent individuals who inhabited Croatia throughout: a) the Late Medieval period (1100-1400 AD) a period of relative prosperity and peace prior to the arrival of Ottoman Turks, and b) individuals who inhabited Croatia in the Historic period (1400-1700 AD) during which time the Ottoman Empire gradually expanded into East and Central Europe. The research will reconstruct Historic period health, diet, weaning practices, and disease and trauma patterns by comparing them with data from the Late Medieval period using bioarchaeological, paleopathological and stable isotope analyses of human burials from Croatia. The project is a collaboration between researchers and postgraduate students who specialize in bioarchaeology, paleopathology, paleodemography, paleodontology, radiology and stable isotope analyses from four institutions: the Croatian Academy of Sciences and Arts, the School of Dental Medicine of the University of Zagreb, the Department of Diagnostic and Interventional Radiology of the University Hospital Dubrava, and the McDonald Institute for Archaeological Research of the University of Cambridge. ]]></summary_en></project><project>
<id>3648</id><title_hr><![CDATA[Supramolekulska kontrola fotokemijskih reakcija eliminacije]]></title_hr><title_en><![CDATA[]]></title_en><user_id>376</user_id><user_firstLast_name>Nikola Basaric</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-3703</code><acronim><![CDATA[SupraPhotoE]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>24377</team_members_id><team_members_names><![CDATA[ Doktorand: Katarina Zlatić ]]></team_members_names><keywords_hr><![CDATA[fotokemija, supramolekulska kemija, karbeni, policikličke molekule, ftalimidi, kinon-metidi,]]></keywords_hr><keywords_en><![CDATA[photochemistry, supramolecular chemistry, carbenes, polycyclic molecules, phthalimides, quinone methides]]></keywords_en><summary_hr><![CDATA[Dinamika supramolekulskih sustava omogućava kontrolu fotokemijske reaktivnosti i otvara mogućnosti za reakcije koje se konvencionalnim postupcima sinteze, termičkim reakcijama u izotropnoj otopini ne mogu provesti. Glavna strategija predloženog projekta je primijeniti različite supramolekulske sustave za kontrolu fotokemijske reaktivnosti. Očekuje se da će predloženo istraživanjo povećati fundamentalna znanja iz supramolekulske kemije, fotofizike i fotokemije policikličkih molekula u izotropnim medijima i supramolekulskim kompleksima. Istraživanje će biti usmjereno na tri reakcije fotoeliminacije: eliminaciju dušika iz diazirina i diazo prekursora uz nastajanje karbena, fotodekarboksilaciju različitih derivata aktiviranih s ftalimidnim kromoforom i fotodehidrataciju i deaminaciju kojom nastaju kinon-metidni intermedijeri. Aspekti kojima ćemo se baviti su učinak molekulske geometrije na reaktivnost i konstantu stabilnosti inkluzijskih kompleksa, kao i utjecaj kompleksiranja na fotofizička svojstva različitih kromofora, učinkovitost fotokemijskih reakcija i raspodjelu produkata. U vezi s predloženim istraživanjem bit će neophodno provesti sintezu velikog broja molekula, dobro definirane i u nekim slučajevima i iznimno složene strukture, što će sigurno zahtijevati značajne inovacije u sintetskoj metodologiji i razvoju postojećih tehnika. Znanstveni ciljevi projekta će ići dalje od trenutnih spoznaja kroz potragu za bio-medicinskim primjenama. Nizu spojeva će biti ispitana antiproliferativna aktivnost, pri čemu će se odrediti &#39;&#39;lead&#39;&#39; spojevi za daljnja istraživanja i potencijalni razvoj liječenja raka uz minimalne nuspojave.]]></summary_hr><summary_en><![CDATA[Dynamics of the supramolecular systems facilitates control of the photochemical reactivity and opens opportunities for reactions which cannot be conducted by conventional synthetic methods, in the thermal reactions in isotropic solution. The main strategy of the proposed project is to apply different supramolecular systems to control photochemical reactivity. The proposed research should increase the fundamental knowledge in supramolecular chemistry, photophysics and photochemistry of the polycyclic molecules in isotropic media and the supramolecular complexes. The research will be focused on three photoelimination reactions: extrusion of nitrogen from diazirines and diazo precursors (giving carbenes), photodecarboxylation of different derivatives activated by phthalimides, and photodehydration and photodeamination giving quinone methide intermediates. The aspects which we will address include the effects of molecular geometry on reactivity and stability constants of the inclusion complexes, as well as influence of the complexation on the photophysical properties of different chromophores, efficiency of the photochemical reactions and product distribution. In connection with the proposed investigations it will be necessary to synthesize a large number of well defined and in some cases extremely complex molecules which will certainly ask for substantial innovations in the synthetic methodology and development of the existing techniques. The scientific goals of the project will go beyond the state of the art and search for bio-medical applications. A series of compounds will be screened for antiproliferative activity, providing lead molecules for further research and potential development of cancer treatment with minimal side effects.]]></summary_en></project><project>
<id>3651</id><title_hr><![CDATA[Satelitska DNA u genskoj regulaciji i ekološkoj adaptaciji]]></title_hr><title_en><![CDATA[]]></title_en><user_id>183</user_id><user_firstLast_name>Đurđica Ugarković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-4635</code><acronim><![CDATA[SatGenReg]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>21311</team_members_id><team_members_names><![CDATA[ Doktorand: Antonio Sermek ]]></team_members_names><keywords_hr><![CDATA[satelitska DNA, genska ekspresija, epigenetika, genska regulacija, adaptacija, Tribolium]]></keywords_hr><keywords_en><![CDATA[satellite DNA, gene expression, epigenetics, gene regulation, adaptation, Tribolium]]></keywords_en><summary_hr><![CDATA[Ponovljena DNA kao npr. transpozoni, može biti izvor regulatornih sekvenci te doprinijeti raspršenju regulatornih elemenata unutar eukariotskog genoma. Međutim, utjecaj na gensku regulaciju druge skupine vrlo zastupljenih, uzastopno ponovljenih sekvenci DNA kao što je satelitska DNA, nije do sada pokazan. U crvenom brašnaru Tribolium castaneum (Coleoptera) satelitska DNA igra važnu ulogu u regulaciji i remodeliranju heterokromatina tijekom razvoja i odgovora na vanjski stres. Ekspresija glavne satelitske DNA je jako potaknuta termičkim stresom, a povećana razina malih interferirajućih RNA (siRNA) koje potječu od satelitske DNA je praćena povećanjem represivnih epigenetskih modifikacija na histonima u heterokromatinu. Uz prisustvo u heterokromatinu, kratki odsječci satelitske DNA su raspršeni u blizini protein-kodirajućih gena u eukromatinu. Transkripcija glavne satelitske DNA osjetljiva na okolišne uvjete kao i njena raspršenost u susjedstvu gena upućuje na moguću ulogu satelitskih elemenata u regulaciji genske aktivnosti i adaptaciji na uvjete u okolišu.Cilj predloženog projekta je ispitati ulogu satelitske DNA u regulaciji aktivnosti gena u kukcu T. castaneum. Mi pretpostavljamo da siRNA koja potječe od satelitskih DNA utječe na epigenetski status dijelova eukromatina koji sadrže raspršene satelitske elemente na način da specifično navodi kromatinske modifikatore, primarno histonske metiltransferaze, na te regije. To može dovesti do nastanka heterokromatina na raspršenim satelitskim DNA elementima  i njegovog širenja na susjedna područja. Takova „heterokromatizacija“ može utjecati na ekspresiju susjednih gena, vjerojatno smanjujući njihovu aktivnost. Očekujemo da će naši rezultati po prvi put pokazati ulogu satelitskih DNA u podešavanju genske ekspresije i u ekološkoj adaptaciji.]]></summary_hr><summary_en><![CDATA[Repetitive elements such as transposons can be a source of regulatory sequences and could act to distribute regulatory elements throughout the genome. However, for the repetitive elements organized in tandem, known as satellite DNAs, role in gene regulation is not described till now. In the red flour beetle Tribolium castaneum (Coleoptera) satellite DNAs play an important role in heterochromatin regulation and remodelling during development and environmental stress response. Expression of a major satellite DNA is strongly induced by heat shock, and increased level of satellite-derived small interfering RNAs (siRNAs) is accompanied by increase of repressive epigenetic modifications of histones at heterochromatin. In addition to their presence in the heterochromatin, short stretches of satellite DNA have been mapped in the close vicinity of numerous genes within euchromatin. The environmentally susceptible transcription of a major satellite DNA as well as its distribution close to protein-coding genes provides strong support for the role of satellite DNA in gene regulation and adaptation to different environmental conditions.The aim of the proposed project is to investigate the gene-regulatory role of satellite DNAs in insect T. castaneum. We propose that satellite DNA-associated siRNAs could affect epigenetic state of euchromatic regions containing dispersed satellite elements by targeting these elements in a sequence-specific manner and by guiding chromatin modifiers, primarily histone methyltransferase. This could result in heterochromatin assembly at dispersed satellite DNA elements and its spreading to the flanking region. Such “heterochromatization” is expected to influence the expression of nearby genes, most probably by decreasing the level of gene expression. We expect that our results will for the first time demonstrate a role of satellite DNAs in the modulation of protein-gene expression and in environmental adaptation. ]]></summary_en></project><project>
<id>3653</id><title_hr><![CDATA[Višekomponentne reakcije u sintezi peptidnih mimetika]]></title_hr><title_en><![CDATA[]]></title_en><user_id>66</user_id><user_firstLast_name>IVANKA JERIĆ</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-3082</code><acronim><![CDATA[MIMICRy]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>21264</team_members_id><team_members_names><![CDATA[ Doktorand: Mladena Glavaš ]]></team_members_names><keywords_hr><![CDATA[peptidomimetici, višekomponentne reakcije, makrociklički spojevi, neprirodne aminokiseline, ugljikohidrati, endiinski spojevi]]></keywords_hr><keywords_en><![CDATA[peptidomimetics, multicomponent reactions, macrocycles, non-natural amino acids, carbohydrates, enediyne compounds]]></keywords_en><summary_hr><![CDATA[Probir biblioteka malih molekula je najčešće korišten pristup u otkriću novih lijekova u posljednih dvadeset godina. Međutim, glavni nedostatak biblioteka je mala raznovrsnost bioloških i kemijskih svojstva spojeva koje sadrže, tj. biblioteke pokrivaju vrlo mali «kemijski prostor». U posljednjih 15 godina, svega 15 % novih kemijskih spojeva zapravo pripadaju novim klasama spojeva. To predstavlja glavnu zapreku razvoju novih vodećih spojeva potrebnih za istraživanje novih bioloških meta. Cilj ovog projekta je proširiti kemijski prostor novim spojevima koji imaju slične karakteristike kao i prirodni spojevi, korištenjem višekomponentnih reakcija. To ćemo postići: (a) razvojem novih gradivnih jedinica temeljenih na neprirodnim aminokiselinama, ugljikohidratima i endiinskim spojevima, (b) provođenjem Passerinijeve i Ugijeve reakcije za dobivanje raznovrsnih linearnih i cikličkih produkata i (c) proučavanjem stereokemije višekomponentnih reakcija.  	Rezultati projekta i znanje o metodologiji, stereokemiji i svojstvima novih spojeva značajni su za istraživanja u više područja: medicinska kemija (nove strukture za obogaćivanje biblioteka spojeva), razvoj katalizatora (posebno makrociklički spojevi s endiinskom jedinicoma) i biomedicinska istraživanja (spojevi s ugljikohidratnim strukturnim elementom mogu se koristiti kao biološke probe). Projekt je usklađen s ciljevima Hrvatske zaklade za znanost: razvoj konkurentnog istraživačkog okruženja i stvaranje novih znanja za jačanje hrvatskog gospodarstva. Rezultati projekta će biti temelj za stvaranje bibliteka sa strukturno različitim malim molekulama i makrocikličkim spojevima, kao odgovor na potrebe farmaceutske industrije: identifikacija još nepoznatih bioloških ciljeva i razvoj novih vodećih spojeva. Stoga projekt doprinosi i jednom od ključnih ciljeva u Europskoj uniji: poboljšanju zdravlja građana EU-a za povećanje bogatstva i dobrobiti ljudi. ]]></summary_hr><summary_en><![CDATA[Screening of small-molecule libraries has been the most commonly used tool in drug discovery over the past two decades. However, currently used libraries lack diversity in terms of biological and chemical properties, i.e. “chemical space” covered is infinitely small. In the past 15 years, only 15 % of the emerging novel chemical entities have been novel classes of compounds. This limitation significantly hampers development of novel lead compounds needed to tackle new generations of biological targets. The project goal is to expand the chemical space of natural product-like compounds by using multicomponent reactions. This will be achieved by: (a) developing novel non-natural amino acid-, carbohydrate- and enediyne-based building blocks; (b) performing Passerini and Ugi multicomponent reactions to obtain structurally diverse linear and macrocyclic compounds and (c) studying the stereochemistry of multicomponent reactions. Project results, and the knowledge about methodologies, stereochemistry and properties of novel compounds, are highly relevant for the following fields: medicinal chemistry - novel structures to fill the libraries; catalyst development – particularly enediyne-based macrocycles; and biomedical studies – carbohydrate-based compounds can be used as biological probes. Project is aligned with the goals of the Croatian Science Foundation: development of competitive research environment, and creation of new knowledge for the strengthening the Croatian economy. Project results will be the base for the generation of libraries with structurally diverse peptide-like small molecules and macrocyclic compounds, as an answer to the pharmaceutical industry needs: identification of yet undisclosed biological targets and the development of novel lead compounds. Therefore, project contributes to one the key objectives in the European Union: improving the health of EU citizens for generation of wealth and public wellbeing. ]]></summary_en></project><project>
<id>3654</id><title_hr><![CDATA[Uloga signalnog puta Wnt u epitelno-mezenhimskoj tranziciji]]></title_hr><title_en><![CDATA[]]></title_en><user_id>139</user_id><user_firstLast_name>Nives Pećina-Šlaus</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-7672</code><acronim><![CDATA[WNT4EMT]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>19002</team_members_id><team_members_names><![CDATA[ Doktorand: Anja Bukovac ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Wnt signaling, EMT, brain tumors, invasion, dishevelled, TCF/LEF]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[In the proposed research project we aim to determine the involvement of Dishevelled and TCF/LEF families of human genes in the process of Epithelial-to-Mesenchymal Transition (EMT) in brain tumors. We believe that the changes of structure and expression of the selected genes correlate with the phenotypic changes of tumor cells. EMT is a process very much involved in invasion and progression of tumors. Many oncogenic signaling pathways can induce EMT. The classical Wnt pathway has a particularly tight link with EMT and it has been shown that nuclear translocation of beta-catenin can induce EMT. Wnt pathway is one of the basic cellular pathways whose misregulation plays important roles in tumorigenesis and whose mediators of transcription are members of TCF/LEF family. Another important protein family is the Dishevelled considered to be the central hub of Wnt signaling since it interacts with Wnt receptors and recruits the multiprotein beta-catenin destruction complex. The experiments of the proposed research will use modern methods of molecular biology for the analyses of brain tumor samples of different malignancy grades. The genetic changes will be tracked by PCR/loss of heterozygosity, heteroduplex and Spreadex electorphoresis (Elchrom Scientific, Switzerland) methods. Expression of selected proteins will be studied by immunohistochemistry demonstrating their location in tumor cells. Besides its scientific value, results from the proposed project will have an application in medical diagnostics. Identifying changes in molecules responsible for control of cell motility will give us the preconditions for understanding the invasiveness of brain tumors and offer new disease progression markers. Our experimental evidence would also encourage the development of therapies that specifically interfere with Wnt signaling in cancer. ]]></summary_en></project><project>
<id>3655</id><title_hr><![CDATA[Aproksimacija ovisna o konfiguraciji u nelinearnoj analizi konstrukcija metodom konačnih elemenata]]></title_hr><title_en><![CDATA[]]></title_en><user_id>527</user_id><user_firstLast_name>Gordan Jelenić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-1560</code><acronim><![CDATA[CANFAS]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Temeljne tehničke znanosti, </scie_field_hr><scie_field_en>Basic engineering sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Građevinski fakultet u Rijeci]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Civil Engineering]]></institution_en><team_members_id>22702</team_members_id><team_members_names><![CDATA[ Doktorand: Miran Tuhtan ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[non-linear structural analysis, finite-element method, configuration-dependent approximation, beams, shells, dynamics]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[This proposal explores the configuration-dependent interpolation as a novel, unorthodox and remarkably promising expansion of the framework within which the non-linear finite-element method has been traditionally contained. The basic idea underlying the project stems from an apparent disparity between the rather advanced extensions of the traditional linear finite-element principles to non-linear problems and the fact that the key finite-element concept – that of interpolation of the unknown functions – is surprisingly kept mostly constant, i.e. configuration-independent. Enabling the finite-element approximation to become configuration-dependent is motivated by the existing need to improve the current non-linear finite-element procedures, in particular for mechanical problems defined on non-linear manifolds. This principle is presented as the general concept providing viable novel development paradigm with obvious benefits for a wider class of mechanical problems. The configuration-dependent approximation to be designed shall obey the essential convergence requirements, with its extra flexibility (arising from the potential of the new approximation to vary with the configuration) employed to improve the solution in some clearly defined manner. In particular, during the design process, the following two basic principles will be consistently adhered to:(i) In the limiting case where the non-linear mechanical problem becomes linear, the configuration-dependent approximation sought must coincide with a known reference interpolation for linear analysis.(ii) In a general non-linear situation, the configuration-dependent approximation should preserve a set of selected mechanical or mathematical properties of equilibrium or motion defined beforehand.In this way, a variety of finite-elements for static and dynamic analysis will be derived.]]></summary_en></project><project>
<id>3656</id><title_hr><![CDATA[Istraživanje utjecaja otpadnih voda iz farmaceutskih industrija na sastav i profil antibiotičke rezistencije izloženih mikrobnih zajednica u slatkovodnim sedimentima]]></title_hr><title_en><![CDATA[]]></title_en><user_id>12566</user_id><user_firstLast_name>Nikolina Udiković Kolić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-1635</code><acronim><![CDATA[WINAR]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Biotehnologija, </scie_field_hr><scie_field_en>Biotechnology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>21182</team_members_id><team_members_names><![CDATA[ Doktorand: Milena Milaković ]]></team_members_names><keywords_hr><![CDATA[antibiotička rezistencija, mikrobne zajednice, farmaceutska industrija, otpadna voda, sediment, antibiotici, teški metali, rezistom]]></keywords_hr><keywords_en><![CDATA[antibiotic resistance, microbial communities, pharmaceutical industry, wastewater, sediment, antibiotics, heavy metals, resistome]]></keywords_en><summary_hr><![CDATA[Rastuća rasprostranjenost bakterija rezistentnih na antibiotike trenutno je jedna od najozbiljnijih prijetnji zdravlju. Istraživanja pokazuju da kontinuirani unos antibiotika i teških metala u okoliš doprinosi ovom problemu. Selekcijski pritisak nametnut od strane ovih zagađivala promovirao je razvoj i širenje antibiotičke rezistencije među okolišnim i patogenim bakterijama. Iako je otpad farmaceutske industrije prepoznat kao najvažniji točkasti izvor ovih zagađivala u prihvatnom vodenom okolišu, njegov utjecaj na sastav i profil antibiotičke rezistencije izloženih mikrobnih zajednica nije poznat. Kako bi popunili ovaj važan istraživački jaz, predlažemo primijeniti interdisciplinarni pristup koji će se fokusirati na slatkovodne sedimente koji su pod utjecajem otpadnih voda iz dviju lokalnih farmaceutskih industrija. Procijenit ćemo rasprostranjenost antibiotika i teških metala u tim sedimentima i identificirati potencijalne &#39;&#39;vruće točke&#39;&#39; za razvoj rezistencije. Geni koji kodiraju za antibiotičku rezistenciju porijeklom iz &#39;&#39;vrućih točaka&#39;&#39; i referentnih mjesta bit će otkriveni primjenom funkcionalne metagenomike. Ovaj pregled bit će osnova za kvantitativnu studiju koja će uspostaviti prostorno-vremensku poveznicu između industrijskog ispusta i zastupljenosti antibiotičke rezistencije. Ovi podaci, u kombinaciji sa hvatanjem rezistentnih plazmida direktno iz bakterija sedimenta u modelni patogen, bit će kritični za donošenje zaključaka o širenju rezistencije među bakterijama. Kompletno sekvenciranje mobilnih plazmida će nadalje pomoći u identifikaciji novih plazmida koji nose grupirane gene za rezistenciju na antibiotike i teške metale. Konačno, utjecaj ispusta na dinamiku sastava bakterijskih zajednica u sedimentima bit će analiziran Ilumina sekvenciranjem 16S rRNA gena. Vjerujemo da će dobivena saznanja imati vitalne implikacije na razvoj učinkovitih strategija upravljanja kako bi se smanjilo širenje antibiotika i antibiotičke rezistencije preko okolišnih puteva.]]></summary_hr><summary_en><![CDATA[The increasing prevalence of antibiotic resistant bacteria is currently one of the most serious health threats. There is growing evidence that continuous environmental discharge of antibiotics and heavy metals contributes to this issue. The selection pressure imposed by these pollutants has promoted the development and spread of antibiotic resistance among environmental bacteria and pathogens. Although pharmaceutical waste is recognized as the most important point source of these pollutants in the receiving aquatic environment, its impact on the composition and antibiotic resistance profile of exposed microbial communities is not known. To fill this important research gap, we propose to take an interdisciplinary approach focusing on freshwater sediments impacted by wastewaters of two local pharmaceutical industries. We will assess the prevalence of antibiotics and heavy metals in these sediments and identify potential hot spots for resistance evolution. Antibiotic resistance genes from hot spots and reference sites will be discovered using functional metagenomics. This will lay the groundwork for a quantitative study that will establish spatio-temporal relationships between industrial discharge and the occurrence of antibiotic resistance. This, in combination with direct capturing of resistance plasmids from sediment bacteria to a model pathogen will be critical to draw conclusions about the spread of resistance genes among bacteria. Complete sequencing of transferable plasmids will furthermore assist in identifying novel plasmids that carry clustered antibiotic and heavy metal resistance gene loci. Finally, the impact of discharge on dynamics of sediment community composition will be analyzed by Illumina sequencing of 16S rRNA genes. We believe that the obtained knowledge will have vital implications for the development of effective management strategies to reduce the spread of antibiotics and antibiotic resistance determinants via environmental pathways.]]></summary_en></project><project>
<id>3657</id><title_hr><![CDATA[Fizika Standardnog modela i njena proširenja]]></title_hr><title_en><![CDATA[]]></title_en><user_id>2665</user_id><user_firstLast_name>Blaženka Melić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-6029</code><acronim><![CDATA[PhySMaB]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>21412</team_members_id><team_members_names><![CDATA[ Doktorand: Domagoj Leljak ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[theoretical particle physics,  Standard Model, perturbative calculations, physics beyond Standard Model, neutrinos]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[In high energy particle physics it is widely believed that the energy frontier experiments at LHC and the planned linear colliders, ILC and/or CLIC, together with ongoing and new experiments in neutrino and flavour physics will unravel fundamental problems in particle and astroparticle physics. A prerequisite for this progress is the complete understanding of the Standard model (SM) predictions. One of the triumphs of SM physics has been the extent to which QCD successfully describes strong interaction processes observed at colliders. More accurate QCD calculations are nowadays essential in understanding the enormous amount of available high-precision data, particularly since new physics effects are obscured by standard QCD processes. Our focus in that area will be to improve the description of hard exclusive processes by including higher-order contributions and by further developing the corresponding methods for automatic QCD calculations. Furthermore, we plan to do precision studies of top-quark production and decay observables which provide a unique view to the mechanism of electroweak symmetry breaking, important for understanding of particle mass generation. In the top-quark decay the information about its spin polarization imprinted by the production process is preserved, and can be calculated and measured in angular distributions of decay products providing other way to search for deviations from the SM expectations. Regarding new physics, the fact that neutrinos have a mass already requires an extension of the SM and calls for an understanding of the origin of neutrino masses. The seesaw mechanism, included in a theory as the one where left-right symmetry (parity) is restored at accessible LHC energies, stands out as a prominent theoretical candidate, and this theory links the origin of neutrino masses to new interactions at high energies and to the restoration of parity. A phenomenological investigation of these predictions is thus compelling and timely.]]></summary_en></project><project>
<id>3658</id><title_hr><![CDATA[Razumjevanje puta ulaska Adenovirusa tipa 26 u stanicu: način poboljšanja vektora za vakcinaciju]]></title_hr><title_en><![CDATA[]]></title_en><user_id>12819</user_id><user_firstLast_name>Dragomira Majhen</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-1358</code><acronim><![CDATA[AdVEntPathVac]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>21250</team_members_id><team_members_names><![CDATA[ Doktorand: Davor Nestić ]]></team_members_names><keywords_hr><![CDATA[adenovirus tip 26, vektor, vakcinacija, unutarstanično putovanje, TLR, urođeni imunološki odgovor]]></keywords_hr><keywords_en><![CDATA[adenovirus type 26, vector, vaccination, intracellular trafficking, TLR, innate immune response]]></keywords_en><summary_hr><![CDATA[Adenovirusni  vektori imaju potencijalno translacijsku i komercijalnu vrijednost, a trenutno se istražuju kao vektori za prijenos DNA i vakcinu. Imunogeničnost adenovirusa tipa 26 (AdV26) značajno se razlikuje od drugih adenovirusnih vektora  što bi mu moglo dati  prednost pred ostalim adenovirusnim serotipovima u razvoju vakcina. Trenutno nema studija koje opisuju ulazak AdV26 u stanicu ističući potrebu za istraživanjem načina na koji AdV 26 inficira stanicu. U skladu s tim, ciljevi ovog projekta su istraživanje AdV26 receptora, vezanja i internalizacije AdV26 u ciljnu stanicu, AdV26 unutarstaničnog putovanja te urođenog imunološkog odgovora potaknutog infekcijom AdV26. Naši znanstveni ciljevi su novi i inovativni te usmjereni prema stvaranju novih znanja i rješenja kliničkih problema, a predložene metode koriste trenutno stanje tehnike. Ovim projektom uvodimo novo istraživanje u području adenovirusnih  vektora što našu grupu stavlja na uzbudljiv i vodeći rub istraživanja adenovirusa. Uspostavom ovog istraživanjanaša bi grupa postala dio mreže industrijsko-akademskog partnerstva u bazičnim i translacijskim istraživanjima adenovirusa u Europi što bi nam omogućilo ostvarivanje daljnjih suradnji i povećalo mogućnost dobivanja novih financiranja u budućnosti. Vjerujemo da će nova znanja koja će proizaći iz našeg istraživanja imati značajan utjecaj u području istraživanja  te biti od koristi kako akademskoj zajednici tako i industriji. Naša grupa, čije se osnivanje predlaže u ovom projektu, jedina je istraživačka grupa koja proučava bazičnu biologiju adenovirusnih vektora u Hrvatskoj čime se osigurava nastavak aktivnog istraživanja adenovirusa u Institutu Ruđer Bošković.]]></summary_hr><summary_en><![CDATA[Adenovirus (AdV) based vectors have potential translational and commercial values and are currently studied as vectors for DNA transfer and vaccination. Adenovirus type 26 (AdV26) has fundamental differences in immunogenicity from other AdV vectors, which might give it advantage over other AdV serotypes in vaccine vector development. To the best of our knowledge there are no reports describing AdV26 entry pathway underlining the need for studying infection pathway used by AdV26. Accordingly, the main objectives of this study are investigating AdV26 receptor usage, binding, internalization, intracellular trafficking and AdV26 mediated induction of innate immune response. Our scientific objectives are novel, innovative and designed to generate new knowledge and opportunities for therapeutic advances in areas of unmet clinical need. Our technical objectives use state-of-the-art, span academic and industrial specialties creating cross sector knowledge and long lasting inter-sectoral benefits. With this project we will introduce new line of AdV vector research in our group that would position us on the exciting and cutting edge of AdV research. Herewith we will become part of long lasting network of industrial–academic partnership in adenovirus basic and translational research across Europe granting lasting collaborations and increasing possibilities for obtaining new grants in the future. We believe that outputs of our research will have considerable impact on the field through gaining new knowledge from which both academia and industry will benefit. Our group, whose establishment is proposed in this project, is the only research group that studies basic biology of adenovirus vectors in Croatia and this grant proposal represents continuation of active adenovirus research in Ruđer Bošković Institute.]]></summary_en></project><project>
<id>3659</id><title_hr><![CDATA[Generalizirana geometrija i simetrije]]></title_hr><title_en><![CDATA[]]></title_en><user_id>52</user_id><user_firstLast_name>Larisa Jonke</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-9750</code><acronim><![CDATA[GGSymm]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>22491</team_members_id><team_members_names><![CDATA[ Doktorand: Clay James Grewcoe ]]></team_members_names><keywords_hr><![CDATA[generalizirana kompleksna geometrija, nekomutativna geometrija, baždarne teorije, matrični modeli, fuzzy prostorir]]></keywords_hr><keywords_en><![CDATA[generalized complex geometry, non-commutative geometry, gauge theory, matrix models, fuzzy spaces]]></keywords_en><summary_hr><![CDATA[Ujedinjenje Einsteinove teorije opće relativnosti s kvantnom fizikom predstavlja jedan od najvećih izazova moderne teorijske fizike. Jedna pretpostavka zajednička svim istraživačkim smjerovima usmjerenih ka razumijevanja kvantne teorije gravitacije jest  da  za  opis geometrije prostor-vremena nije dostatna  klasična slika prostor-vremena kao diferencijabilne mnogostrukosti. U okviru ovog projekta smo zainteresirani za generalizirane geometrije motivirane fizikom teorije struna; generalizirana kompleksna geometrija i nekomutativna geometrija. Naš cilj jest  bolje razumijevanje  kako spomenute ideje generalizirane geometrije   iskoristiti u generalizaciji načela simetrije. Konkretno, zainteresirani smo za proširenje baždarnog principa, ključne ideje koji se koristi u fizici za opis svih (poznatih) međudjelovanja materije, a u svjetlu ovih proširenja klasične geometrije. Želimo opisati učinke dualnosti u teoriji struna, nekomutativne baždarne teorije te  viših baždarnih teorija u okviru učinkovne teorija polja koja nam je potrebne za obavljanje pouzdanih izračuna koje je moguće eksperimentalno provjeriti. Očekujemo da će nam geometrizacija ovih poopćenih simetrija pružiti, u dugogodišnjoj perspektivi, konzistentan okvir unutar kojeg bi se mogla riješiti neka od otvorenih pitanja u kozmologiji i fizici crnih rupa.]]></summary_hr><summary_en><![CDATA[The unification of Einstein&#39;s theory of general relativity with quantum physics represents one of the greatest challenges of modern theoretical physics. A hypothesis common to all research directions aiming at understanding the quantum theory of gravity is that our description of space-time geometry has to go beyond the classical picture of space-time as a differentiable manifold.  Within this project we are interested in generalized concepts of geometry, physically motivated by string theory: generalized complex geometry and non-commutative geometry. We aim at improving our understanding on how these generalized notions of geometry could be utilized to obtain consistent extensions of symmetry principles. In particular, we are interested in extending the gauge principle, the key physical notion used to describe all (known) matter interactions, in view of the above generalizations of classical geometry. Our goal is to capture the effects of string duality symmetries, non-commutative gauge theory and higher gauge theories at the level of the effective field theory description, which is necessary in order to perform reliable calculations and yield experimentally testable predictions. We expect that geometrizing these generalized symmetries would provide us, as a long-term perspective, with a consistent framework within which one could address open issues in cosmology and black-hole physics.]]></summary_en></project><project>
<id>3663</id><title_hr><![CDATA[Utjecaj magnetske anizotropije na kvantne spinske sustave]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3184</user_id><user_firstLast_name>Tomislav Ivek</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-3515</code><acronim><![CDATA[IMAQSS]]></acronim><duration>06.12.2016 - 05.12.2021</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut za fiziku]]></institution_hr><institution_en><![CDATA[Institute of Physics in Zagreb]]></institution_en><team_members_id>21233</team_members_id><team_members_names><![CDATA[ Doktorand: Martina Dragičević ]]></team_members_names><keywords_hr><![CDATA[Kvantni spinski sustavi, niskodimenzionalni magneti, magnetska anizotropija, torque magnetometrija, elektronska spinska rezonancija]]></keywords_hr><keywords_en><![CDATA[Quantum spin systems, low-dimensional magnets, magnetic anisotropy, torque magnetometry, esr spectroscopy]]></keywords_en><summary_hr><![CDATA[Proučavanje magnetskih materijala donijelo nam je razumijevanje mnogih fizikalnih pojava te doprinijelo razvoju novih tehnologija. Magnetizam je kvantna pojava koja dolazi od interakcija superizmjene među magnetskim momentima u materijalu. Razumijevanje utjecaja tih interakcija na formiranje materijala sa specifičnim magnetskim svojstvima jedan je od glavnih problema u znanosti o materijalima. U niskodimenzionalnim kvantnim spinskim sustavima interakcije među spinovima su često opisane izotropnim Heisenbergovim hamiltonijanom. Eksperimentalni rezultati ukazuju na važnost slabih anizotropnih interakcija te zahtijevaju nova teorijska istraživanja. Te interakcije induciraju nove zanimljive pojave s velikim potencijalom za primjenu te je nalaženje novih metoda osjetljivih na njihovu detekciju od velike važnosti.Cilj ovog projekta je eksperimentalno istraživanje utjecaja magnetske anizotropije na odabrane kvantne spinske sustave kombinacijom dviju iznimno osjetljivih tehnika: torque magnetometrije i spektroskopske metode elektronske spinske rezonancije (ESR). Istraživat ćemo uzorke čiji magnetizam dolazi od spinova S=1/2, a koji se mogu klasificirati kao male spinske nakupine, kvazi-jednodimenzionalni Heisenbergovi antiferomagneti i/ili magnetoelektrici. Kombinacija spomenutih tehnika dat će novu metodologiju za istraživanje utjecaja magnetske anizotropije na kvantne spinske sustave i druge magnetske materijale te doprinijeti razumijevanju pojava induciranih magnetskom anizotropijom.U ovom projektu ostvarit će se suradnja između fizičara i kemičara sa svrhom sinteze novih visokokvalitetnih magnetskih materijala. Istraživanja će biti fokusirana na te materijale i na uzorke dobivene iz inozemnih ekspertnih laboratorija. Glavni cilj ovog projekta je formiranje nove istraživačke grupe s ekspertizom u istraživanju pojava induciranih anizotropijom u novim magnetskim materijalima.]]></summary_hr><summary_en><![CDATA[Study of magnetic materials provides us with understanding many of physical phenomena and continues to provide us with new technologies. Magnetism is a quantum phenomenon emerging from the superexchange interactions between magnetic moments in the material. Understanding how these interactions bring forth a material with specific magnetic properties is one of the key questions in materials science. In low-dimensional quantum spin systems the interactions between the spins are often described by the isotropic Heisenberg Hamiltonian. The importance of weak anisotropic interactions emerges from experiments and requires new theoretical treatments. These interactions are found to induce new interesting phenomena with great potential for applications in emerging technologies. Exploiting new methods sensitive to these interactions is thus crucial. Aim of this project is to experimentally investigate the influence of magnetic anisotropy on chosen quantum spin systems by combining two highly sensitive techniques: torque magnetometry and electron spin resonance (ESR) spectroscopy. Our study is focused on samples with magnetism coming from electron spin S=1/2, which can be classified as weakly interacting small spin clusters, quasi one-dimensional Heisenberg antiferromagnets and/or magnetoelectrics. The combination of mentioned techniques allows a new methodology for investigation of the influence of magnetic anisotropy on quantum spin systems and other magnetic materials and will provide important input in understanding of anisotropy induced phenomena.Within this project a collaboration between physicists and a chemist will be established with the purpose of synthesising new high-quality magnetic materials. Our study will focus on these materials, and on samples synthesized in expert laboratories abroad. The main aim of this project is to form a new independent research group highly qualified to investigate the anisotropy induced phenomena in new promising magnetic materials.]]></summary_en></project><project>
<id>3664</id><title_hr><![CDATA[Novi metodološki pristup biogeokemijskim istraživanjima specijacije metala u tragovima u obalnim vodenim ekosustavima]]></title_hr><title_en><![CDATA[]]></title_en><user_id>12557</user_id><user_firstLast_name>Dario Omanović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-4500</code><acronim><![CDATA[MEBTRACE]]></acronim><duration>10.10.2017 - 10.11.2021</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>23224</team_members_id><team_members_names><![CDATA[ Doktorand: Saša Marcinek ]]></team_members_names><keywords_hr><![CDATA[metali u tragovima, specijacija, obalni vodeni ekosustavi, modeliranje,  sedimenti, zagađivala]]></keywords_hr><keywords_en><![CDATA[trace metals, speciation, coastal aquatic ecosystems, modeling, sediments, contaminants]]></keywords_en><summary_hr><![CDATA[Predloženo istraživanje ima za cilj razjasniti nekoliko pitanja vezanih za fizičko-kemijske procese koji reguliraju ponašanje tragova metala (TM) u čistim, ali i u potencijalno zagađenim prijelaznim i priobalnim vodenim ekosustavima. Pokretljivost, reaktivnost kao i bioraspoloživost MT-ova jako ovise o njihovoj kemijskoj specijaciji, bez obzira imaju li ulogu mikronutrijenata ili  su izrazito toksični za organizme.Naša istraživanja usmjerena prema karakterizaciji međusobnog odnosa TM-ova s ostalim makro i mikro konstituentima prirodnih voda, posebno s prirodnom organskom tvari, bit će temeljena na korištenju najnovijih elektrokemijskih i složenih spektrometrijskih tehnika za specijaciju metala. Orijentirat ćemo se naročito na razvoj i usavršavanje metoda za specijaciju, mjernih protokola i mjernih senzora. Modele raspodjele metala razvijene u laboratorijskim uvjetima ispitat ćemo na uzorcima prirodne vode, a primijenit ćemo ih i kod on-site i in-situ mjerenja. Istraživanja će voditi do uspostavljanja niza specifičnih fizičko-kemijskih parametara, procedura i kriterija koja će omogućiti pouzdanu procjenu aktualnog stanja ali i predviđanje budućeg ponašanja TM-ova (specijaciju, mobilnost, biodostupnost/toksičnost) u slučaju lokalnih okolišnih nezgoda (npr. zagađenja) ili globalnih prijetnji (npr. “ocean acidification”).Istraživanja će se provoditi u vodnim područjima raznolikog kemijskog sastava gdje se očekuju promjene fizičko-kemijskih oblika TM-ova (As, Cd, Co, Cr, Cu, Fe, Hg, Ni, Pb, Zn), a uključivat će estuarijska, oksično/anoksična, eutrofička, te čista i zagađena područja, u kojima će se istraživati procesi koji se odvijaju kako na granicama faza, tako i u vodenom i sedimentnom stupcu.Teme istraživanja odabrane su tako da rezultati projekta budu od koristi ne samo široj znanstvenoj zajednici koja radi na problemima specijacije TM-ova nego i institucijama ovlaštenim za upravljanje priobalnim područjima.]]></summary_hr><summary_en><![CDATA[The proposed research aims at elucidating several issues related to the physico-chemical processes governing trace metals (TM) behaviour in pristine, but also in potentially contaminated transitional and coastal aquatic ecosystems. Whether the TMs behave as micronutrients or are highly toxic to organisms, their mobility, reactivity as well as bioavailability, strongly depends on chemical speciation.Our focus will be directed towards characterisation of interactions of TM with other macro and micro constituents of natural waters, particularly with natural organic matter, by employing the most recent approaches utilizing electrochemical and hyphenated spectrometric techniques. Particular effort will be invested in the development and improvement of speciation methods, measurement protocols and sensing electrodes. Methodologies developed under controlled laboratory conditions will be verified using natural water samples and applied in on-site and in-situ field-studies. The research will lead to the establishment of sets of specific measures and criteria which will allow reliable estimation of the actual state, but also the prediction of future behaviour of TMs (speciation, mobility, bioavailability/toxicity) in case of local environmental accidents (e.g. contamination) or global threats (e.g. ”ocean acidification”).Aquatic environments characterized by a variety of chemical compositions will be studied. In such conditions, variations in physical-chemical forms of the studied TMs (As, Cd, Co, Cr, Cu, Fe, Hg, Ni, Pb, Zn) are expected to occur. Study sites will be estuarine, oxic/anoxic, eutrophic and clean/contaminated areas, in which processes occurring at the phase boundaries, as well as in the sediment and water column will be explored.The specific subjects of the research are selected in a way to enable the outcome of the project be valuable not only to the broad scientific community working on TM speciation, but also to the authorities managing coastal zones.]]></summary_en></project><project>
<id>3666</id><title_hr><![CDATA[Novo poglavlje u procesima prijenosa naboja u vodenim otopinama]]></title_hr><title_en><![CDATA[]]></title_en><user_id>521</user_id><user_firstLast_name>Ivan Ljubić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-5919</code><acronim><![CDATA[CTPAMR]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>21411</team_members_id><team_members_names><![CDATA[ Doktorand: Ivana Nikšić-Franjić ]]></team_members_names><keywords_hr><![CDATA[Radijacijska kemija, Kvantna kemija, Molekulska dinamika, Reakcijski mehanizam, Kinetika, Vodena otopina, Spregnuti prijenos protona i elektrona ]]></keywords_hr><keywords_en><![CDATA[Radiation chemistry, Quantum chemistry, Molecular dynamics, Reaction Mechanism, Kinetics, Aqueous solution, Proton-coupled electron transfer]]></keywords_en><summary_hr><![CDATA[Procesi prijenosa naboja u vodenom mediju od iznimnog su interesa zbog svoje ključne uloge u biokemiji i dizajnu sustava za pretvorbu energije. Unatoč opsežnim dugogodišnjim istraživanjima, načini prijenosa naboja i njihova ovisnost o reakcijskim uvjetima još su uvijek nedovoljno poznati. Sinergijskom kombinacijom eksperimentalnih i računskih pristupa nadamo se ostvariti značajan napredak u razumijevanju mehanizama i kinetike prijenosa naboja u reakcijama slobodnih radikala u vodenom mediju, posebice spregnutog prijenosa protona i elektrona (PCET). Težište će biti na reakcijama alfa-hidroksialkilnih i alfa-aminoalkilnih radikala s halogeniranim organskim supstratima te ovisnost prinosa dehalogenacije o prisutnosti i svojstvima pufera. U sličnim uvjetima planiramo studirati i reduktivna svojstva atoma vodika, što potencijalno pruža fascinantnu mogućnost istraživanja najfundamentalnijih aspekata PCET procesa. Istraživanja će se provoditi gama-radiolizom puferiranih vodenih otopina i kvantitativnim mjerenjima vrste i prinosa nastalih produkata u kombinaciji s kvantno-kemijskim i dinamičkim računalnim metodama, kako u svrhu racionaliziranja eksperimentalnih rezultata tako i za usmjeravanje eksperimenata. Budući da je PCET u ovim sustavima popraćen lančanom reakcijom koja znatno povećava prinose dehalogenacije, namjeravamo iznaći najpovoljnije uvjete za usmjeravanje reakcije u PCET kanal, posebice u odnosu na kompetitivne kanale radikalske supstitucije i adicije. Uspješno ostvarenje ciljeva projektnog prijedloga bitno će pridonijeti rješavanju središnjeg problema kemije slobodnih radikala u vodenim otopinama, tj. na koji način dizajnirati reakcijske uvjete, primjerice pH te koncentracije reaktanata i pufera, kako bi se radikalska reakcija učinkovito usmjerila prema određenom reakcijskom kanalu i na taj način optimizirao prinos produkata.]]></summary_hr><summary_en><![CDATA[Charge transfer processes in aqueous media are of a huge and ongoing interest due to their vital role in biochemistry and energy conversion applications. Despite extensive body of research invested in these processes, various modes of charge transfer and dependence thereof upon the reaction conditions are still insufficiently understood. By a synergistic combination of experimental and computational approaches, we hope to make major advances in understanding of the mechanisms and kinetics of charge transfer in free radical reactions in aqueous media, particularly of the proton-coupled electron transfer (PCET). Our focus will be on the reactions of the a-hydroxyalkyl and a-aminoalkyl radicals with halogenated organic substrates, and how the product yields of such a radical-induced dehalogenation are influenced by several buffer systems. In the similar context, we also plan to study reductive properties of the hydrogen atom, which offers a fascinating prospect of exploring the PCET process at its most fundamental. The reactions will be incited by the g-radiolysis of buffered aqueous solutions, followed by the detection and quantitative measurement of the products. This will be accompanied by quantum-chemical and molecular dynamical calculations, both to help rationalize the experimental findings and to guide the experiments. Because the PCET in these systems is remarkably accompanied by a chain reaction that greatly enhances the dehalogenation yields, we intend to elucidate the favorable conditions for the PCET to occur, especially as opposed to the rival free radical substitution and addition. A successful accomplishment of the objectives will be instrumental for resolution of the central problem in the aqueous chemistry of free radicals, and that is how to rationally design the specific reaction conditions, e.g. pH, reactant and buffer concentrations, in order to steer a free-radical induced reaction and optimize the yield due to a desired reaction channel.]]></summary_en></project><project>
<id>3668</id><title_hr><![CDATA[Novi enološki postupci kao alternativa sumporovom dioksidu u proizvodnji visokokvalitetnih vina]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6224</user_id><user_firstLast_name>Karin Kovačević Ganić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-5064</code><acronim><![CDATA[LOWSULF-HQWINE]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Prehrambena tehnologija, </scie_field_hr><scie_field_en>Food technology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Food Technology and Biotechnology]]></institution_en><team_members_id>21313</team_members_id><team_members_names><![CDATA[ Doktorand: Katarina Lukić ]]></team_members_names><keywords_hr><![CDATA[Vino, SO2, antimikrobno djelovanje, kvaliteta vina, ultrazvuk visokog intenziteta (HPU), visoki hidrostatski tlak (HHP), hladna plazma (NTP)]]></keywords_hr><keywords_en><![CDATA[wine, SO2, antimicrobial activity, wine quality, high power ultrasound (HPU), high hydrostatic pressure (HHP) and non-thermal plasma (NTP)]]></keywords_en><summary_hr><![CDATA[Suvremeni zahtjevi za povećanjem sigurnosti i kvalitete vina utjecali su na preporuke o smanjenju, ali i na nove zakonske restrikcije u upotrebi sumporovog dioksida. Naime, zbog svojih antimikrobnih i antioksidacijskih karakteristika, sumporov dioksid jedan je od najučinkovitijih aditiva u proizvodnji vina. Međutim, uslijed potencijalnih pseudo-alergijskih reakcija koje kod osjetljivih pojedinaca dovode do zdravstvenih problema, korištenje sumporovog dioksida danas je pod razmatranjem. Stoga su i znanstvena istraživanja u posljednjem desetljeću intenzivno usmjerena na pronalaženje alternativa sličnih antiseptičkih i antioksidacijskih svojstava, kojima bi se zamijenila/smanjila upotreba sulfita u proizvodnji vina; što i danas predstavlja jedan od najznačajnijih enoloških izazova. U posljednje vrijeme, tehnologije kao ultrazvuk visokog intenziteta (HPU), visoki hidrostatski tlak (HHP) te hladna plazma (NTP) otvorile su nove mogućnosti u kontroli mikrobiološke kvalitete hrane te su stoga našle sve veću primjenu u prehrambenoj industriji. Međutim, primjena ovih novih, netermalnih postupaka u proizvodnji vina i njihov utjecaj na mikrobiološku stabilnost vina do sada nije istražen. Cilj projekta je istražiti mogućnosti primjene HPU, HHP i NTP sa svrhom smanjenja upotrebe sumporovog dioksida u proizvodnji visokokvalitetnih crnih, bijelih i desertnih vina. Ispitat će se utjecaj ovih netermalnih postupaka na cjelokupnu kvalitetu vina, u prvom redu na sastav polifenola, arome te senzorske karakteristike vina. Također, istražit će se mogućnosti ovih postupaka u kontroli mikrobiološke stabilnost vina. Nadalje, ispitat će se i sinergijski učinak navedenih postupaka te dodatka antioksidansa (niži udio sumporovog dioksida i glutation) tijekom dozrijevanja vina u bocama. Rezultati ovog projekta pokazat će kako primjenom novih netermalnih tehnologija samostalno ili u kombinaciji s antioksidansima proizvesti vina poboljšane kvalitete s nižim udjelom sumporovog dioksida.]]></summary_hr><summary_en><![CDATA[Modern increasing requirements for wine safety and quality led to very restrictive legislation regarding sulfur dioxide addition recommending limitations or even complete suppressing. In fact, sulfur dioxide is one of the most efficient additives used in winemaking due to its antimicrobial and antioxidant properties. However, as a result of potential pseudo-allergenic health problems in sensitive individuals use of sulfur dioxide has recently come under the review. Hence, in recent decades, alternatives to reducing/replacing sulfites in winemaking have been extensively studied. However, finding promising substitutes with similar antiseptic and antioxidant characteristics still remains major challenge. Recently, emerging technologies such as high power ultrasound (HPU), high hydrostatic pressure (HHP) and non-thermal plasma (NTP) have entered the field of food science and technology offering, as novel tools, new opportunities for managing food microbiology. Their opportunities in wine microbiology have not been examined. The aim of this project is to study the potential usage of HPU, HHP and NTP in production of high quality red, white and dessert wine as sulfur dioxide reducing strategies, and furthermore to optimize their application. Impact on overall wine quality, particularly chemical and sensory characteristic will be studied. Possibilities of these new technologies in controlling microbiological stability of wine will be investigated. In addition, synergistic practices of these physical technologies with antioxidants (lower content of sulfur dioxide and glutathione) during long period of aging in the bottles will be studied. The results of this project are expected to provide information how application of new physical technologies on its own or in combination with antioxidant addition can lead to wines with lower levels of sulfur dioxide and improved quality.]]></summary_en></project><project>
<id>3669</id><title_hr><![CDATA[Optomehanika uzrokovana frekventnim češljem]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5410</user_id><user_firstLast_name>Ticijana Ban</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-2389</code><acronim><![CDATA[MeCombO]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut za fiziku]]></institution_hr><institution_en><![CDATA[Institute of Physics in Zagreb]]></institution_en><team_members_id>22599</team_members_id><team_members_names><![CDATA[ Doktorand: Neven Šantić ]]></team_members_names><keywords_hr><![CDATA[optomehanika, frekventni češalj, optička šupljina, spektroskopija, koherencija, hladni atomi, rubidij, magneto-optička zamka (MOT), dipolna zamka]]></keywords_hr><keywords_en><![CDATA[optomechanics, frequency comb, optical cavity, spectroscopy, coherence, cold atoms,rubidium, magneto-optical trap (MOT), optical dipole trap]]></keywords_en><summary_hr><![CDATA[Sila na atome uzrokovana kontinuiranim (eng. continuous wave, cw) laserima predstavlja centralni dio istraživanja u području atomske fizike već zadnjih nekoliko desetljeća. Radijativna sila čini osnovu za lasersko hlađenje i zarobljavanje atoma, čime je omogućeno stvaranje dovoljno gustih i hladnih atomskih uzoraka. Ipak, unatoč opsežnom i dobro shvaćenom području optomehanike uzrokovane cw laserom, istraživanja sila na atome uslijed interakcije s nizom ultrakratkih pulseva (odnosno frekventnim češljem) su oskudna. U međuvremenu, rezultati istraživanja provedenih u našoj grupi ukazuju na to da se, u specifičnoj geometriji pobude atoma frekventnim češljem, javljaju posve novi fenomeni koji zahtjevaju dodatna eksperimentalna i teorijska istraživanja.  Cilj ovog projekta je istraživanje novih fenomena koji se javljaju uslijed dijelovanja sile na atome uzrokovane frekventnim češljem (FC), a uključuje fenomene sprezanja i dekoherencije, stvaranja dipolne zamke s fs laserima u blizini atomske rezonancije te hlađenje atoma u optičkoj šupljini (rezonatoru) uzrokovano FC-om. Predložena istraživanja otvorit će nekoliko intrigantnih tema u području istraživanja koje je relevantno znanstvenoj zajednici širom svijeta. Predloženi će projekt utjecati na podizanje prepoznatljivosti hrvatske znanosti u svijetu, zapošljavanje i usavršavanje mladih istraživača i jačanje kapaciteta Instituta za fiziku putem međunarodne suradnje.]]></summary_hr><summary_en><![CDATA[Inducing mechanical action on atoms by continuous wave (cw) laser excitation has been a central topic in atomic physics for decades. Yet, in contrast to the rich and fruitful field of cw-laser-induced optomechanics, the investigations of mechanical action on atoms due to interaction with trains of ultrashort laser pulses (i.e. frequency combs) are scarce in literature. Meanwhile, recent results made in our group have indicated that in a specific excitation geometry an entirely new type of FC-atom interaction emerges that calls out for further experimental and theoretical investigation.The aim of the project is to explore novel phenomena that arise when the mechanical action on cold atoms is induced by frequency comb (FC) excitation, including entanglement and decoherence, near-resonance dipole trap, and frequency-comb-induced cavity cooling. The proposed research will open up several intriguing topics in the field of research that is relevant to the scientific community worldwide.The proposed project will increase the visibility of Croatian science, employ and educate young researchers and strengthen the capacity of the Institute of Physics through international cooperation.]]></summary_en></project><project>
<id>3670</id><title_hr><![CDATA[Primjena nusproizvoda prehrambene industrije za razvoj funkcionalnih i okolišno prihvatljivih ekstrudiranih proizvoda i aditiva ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5093</user_id><user_firstLast_name>Jurislav Babić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-8207</code><acronim><![CDATA[FUNEXFOOD]]></acronim><duration>03.10.2016 - 03.10.2020</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Prehrambena tehnologija, </scie_field_hr><scie_field_en>Food technology, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Prehrambeno-tehnološki fakultet]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Food Technology]]></institution_en><team_members_id>22630</team_members_id><team_members_names><![CDATA[ Doktorand: Marijana Grec ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Functional food, extrusion, cereals, flours, by-products, environment-friendly]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Consumers nowadays are seeking palatable food which has beneficial effect on health. At the same time, they are not ready to change their eating habits – reduce intake of bakery products, fast food etc. and increase intake of fresh fruit and vegetable, whole grain products etc. Therefore, food industry is challenged to create products that are consumed every day (bread, snacks etc.) by large population, which are both enriched with bioactive substances and have desired sensory properties.The aim of this project is to develop new functional and enriched products based on extrusion process. Enriched grains (wheat, maize) will be used as basic material. The improvement and supplementation with biologically active (antioxidants, minerals, vitamns, fibre) will be done by addition of by-products from food industry (fruit and vegetable pomaces, oil cakes) in extrusion process. Extrusion will be used to produce final products: expanded snack products and pasta, as well as modified flours which will be used in production of bakery products and biscuits.All processes - extrusion of snack products and pasta, extrusion for flour modification, pasta drying, baking) will be optimised using response surface methodology. All products will be tested for chemical, physical, thermophysical properties, and optimal products will be sensory analysed.The results of project will be array of flours and final products with defined recipes and optimal production conditions, along with defined application of food industry by-products that significantly load environment and are not currently exploited to satisfying extent.In the project multidisciplinary approach will be applied – from agronomist, over food technologist and process engineers to sensory experts. In addition, close academia-industry links will be developed through different activities.]]></summary_en></project><project>
<id>3671</id><title_hr><![CDATA[Nuklearna struktura i reakcije: eksperimentima prema neutronskoj liniji kapanja]]></title_hr><title_en><![CDATA[]]></title_en><user_id>166</user_id><user_firstLast_name>Suzana Szilner</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-4924</code><acronim><![CDATA[SR-ETNo]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>21302</team_members_id><team_members_names><![CDATA[ Doktorand: Petra Čolović ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[nuclear structure, nuclear reactions, neutron-rich nuclei, nucleon-nucleon correlations, nuclear pairing, nuclear clustering]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Understanding of atomic nuclei relies on knowledge about interaction between their components and details of their relationship. Recent advent of detector arrays allows systematic studies of nuclei away from the region of nuclear stability. With the proper selection of colliding systems and reaction energies, the exchange of nucleons can lead to the population of neutron-rich nuclei, peculiar systems having challenging aspects in their nuclear structure behaviour. The main objective of this research project is to advance understanding of the nuclear reactions and structure in the vicinity of the neutron drip line. By the use of the new generation instrumentation, we will experimentally study three different neutron-rich groups of nuclei: very heavy nuclei (difficult to access experimentally with other methods), medium-mass nuclei (where well known magic numbers disappear), and finally, lower mass nuclei (were the neutron drip line has already been experimentally reached). The major part of the proposed experimental work will be performed at the top international accelerator facilities, but in the well suited cases, the measurements will be performed at the RBI accelerator. The new experimental data will significantly improve our understanding of nuclei far from the stability line and will have a considerable impact on the reaction measurements at next generation of the radioactive beam facilities. Scientists involved in this project are active members of a number of  leading international collaborations in the field, with large experience in experimental research and considerable international reputation. Project PI has remarkable research track record and has led a successful project before. Senior scientists on the project have led a number of competitive projects (funded by MSES, FP7, ESF and Croatian SF). Finally, this project is well integrated with the strategic community document Long Range Plan of the Nuclear Physics European Collaboration Committee.]]></summary_en></project><project>
<id>3672</id><title_hr><![CDATA[Model rasta aneurizme temeljen na biokemijskim i mehaničkim podražajima ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1010</user_id><user_firstLast_name>Igor Karšaj</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-3164</code><acronim><![CDATA[BCMModAneuGr]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, </scie_field_hr><scie_field_en>Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>19003</team_members_id><team_members_names><![CDATA[ Doktorand: Nino Horvat ]]></team_members_names><keywords_hr><![CDATA[aneurizma, abdominalna aorta, intraluminalni tromb, rast i promjena strukture, hiperelastičnost, naprezanja, prilagodba, razgradnja elastina, kolagen]]></keywords_hr><keywords_en><![CDATA[aneurysm, abdominal aorta, intraluminal thrombus, growth and remodeling, hyperelasticity, stress, adaptation, elastin degradation, collagen turnover]]></keywords_en><summary_hr><![CDATA[Modeliranje biokemijskih kao i mehaničkih promjena tijekom razvoja intraluminalnog tromba (ILT) ima potencijal da pomogne nam odgovoriti na pitanje kako dolazi do rasta aneurizme i što uzrokuje njenu rupturu. Konačni cilj ovog istraživanja je utvrditi promjene koje s javljaju rastom aneurizme. Simulirat ćemo od početnog krvnog ugruška pa kasnog stadija aneurizme promjera većeg od 5 cm. Pretpostavljamo da povećanje AAA je izravna posljedica razvoja ILT.  Predlažemo sljedeće ciljeve za ovaj projekt:Cilj 1: Razviti model rasta i promjene strukture fuziformne aneurizme koji je moguće koristiti u paketu za konačne elemente.Cilj 2: Potrebno je razviti trodimenzijski model rasta i promjene strukture sakularne aneurizme s uključenim intraluminalnim trombom.Cilj 3: Potrebno je ispitati različite hipoteze o tome kako dolazi do rupture ili stabilizacije AAA na realističnoj geometriji.Uspješno ostvarenje navedenih ciljeva bit će veliki napredak u polju biomehanike krvnih žila jer će omogućiti po prvi put praćenje kinetike razvoja intraluminalnog tromba unutar AAA i otkrivanje faktora koji utječu na rast i rupturu aneurizme.]]></summary_hr><summary_en><![CDATA[Proper biochemomechanical modeling of the development of an intraluminal thrombus (ILT) has the potential to help us answer the question about reasons for aneurysmal growth and to define parameters influencing potential for rupture?. The overall goal of this project, therefore, is to quantify the development of ILT from the initial blood clot to a mature formation, with special attention to changes in the clot structure. Our hypothesis is that AAA growth is a direct consequence of ILT development. We propose following aims for this proposal:Aim 1: To develop a finite element growth and remodeling model of thrombus-laden fusiform aneurysm from the moment of initiation.Aim 2: To develop a 3-D finite element growth and remodeling model of thrombus-laden saccular abdominal aortic aneurysm from the healthy aorta.Aim 3: To test different hypothesis on AAA rupture and stabilization on realistic geometry from Aim 2.Successful realization of these aims will advance the field of vascular mechanics by allowing for the first time quantification of kinetics of an intraluminal clot within AAA, and factors that significantly influence aneurysmal growth and risk of the rupture. ]]></summary_en></project><project>
<id>3673</id><title_hr><![CDATA[Računalna rješenja u bioznanostima: Značaj savitljivosti molekula]]></title_hr><title_en><![CDATA[]]></title_en><user_id>56</user_id><user_firstLast_name>Borislav Kovačević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-8556</code><acronim><![CDATA[CompSoLS-MolFlex]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>21421</team_members_id><team_members_names><![CDATA[ Doktorand: Luka Bilić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Molecular Flexibility, Computational Chemistry, Peptides, Proteins, Enzyme Catalysis]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Molecular flexibility controls a number of key processes ranging from protein folding to the design of advanced materials. However, the detailed understanding of its impact on a given process is poorly understood. Direct investigation of this phenomenon by experimental means, is a challenging endeavour, as the microscopic details are frequently hidden from macroscopic observations. Computational simulations, on the other hand, provide detailed information regarding molecular dynamics and flexibility. The theoretical approach is thus crucial in both understanding the experimental results and in expanding the underlying conceptual framework.The present project proposes to utilize state-of-the-art computational techniques to address the importance of molecular flexibility across a range of carefully selected examples from the life sciences. The examples, which can be classified under the headings: (i) peptides and spectroscopy, (ii) protein flexibility, and (iii) enzyme related transformations, have been chosen to span multiple time and length scales and thus to highlight the diverse and wide-reaching nature of molecular flexibility. The selected examples exhibit a significant degree complementarity and synergy with one another and are all associated with their own applicative importance in different areas of (bio)chemistry.In addition to the scientific research proposed, the project aims to consolidate a highly successful and competitive platform in computational life sciences that has been established at the RBI. This platform was already recognized through the granting of an EU-FP6 project (2007-2010). The current project team is thus well equipped for the proposed work and exhibits a good balance between senior researchers, with excellent track records, and junior scientists with outstanding potential. The support of the project team by HrZZ is crucial for maintaining their competitiveness in the international scientific environment of computational life sciences.]]></summary_en></project><project>
<id>3674</id><title_hr><![CDATA[EXploisives PrEcursor Defeat by Inhibitor Additives (EXPEDIA)]]></title_hr><title_en><![CDATA[]]></title_en><user_id>738</user_id><user_firstLast_name>MUHAMED SUĆESKA</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-3871</code><acronim><![CDATA[]]></acronim><duration>01.08.2017 - 31.07.2021</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Kemijsko inženjerstvo, </scie_field_hr><scie_field_en>Chemical engineering, </scie_field_en><institution_hr><![CDATA[Ništa od navedenog]]></institution_hr><institution_en><![CDATA[Nothing from this list]]></institution_en><team_members_id>23265</team_members_id><team_members_names><![CDATA[ Doktorand: Barbara Štimac ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>3676</id><title_hr><![CDATA[Električni transport u staklima i staklo-keramici]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4869</user_id><user_firstLast_name>Andrea Moguš-Milanković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-6510</code><acronim><![CDATA[EL-Trass-Ceram]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>21288</team_members_id><team_members_names><![CDATA[ Doktorand: Juraj Nikolić ]]></team_members_names><keywords_hr><![CDATA[Električni prijenos, staklo, staklo-keramika, elektronsko-ionska vodljivost, efekt &#39;&#39;miješanih&#39;&#39; staklotvoraca]]></keywords_hr><keywords_en><![CDATA[Electrical transport, glass, glass-ceramics, mixed ionic-electronic conductivity, mixed glass former effect]]></keywords_en><summary_hr><![CDATA[Izraženi zahtjevi suvremenih tehnologija za novim materijalima sa specifičnim svojstvima otvaraju velike mogućnosti u istraživanju stakala i staklo-keramike. Priprava novih stakala i staklo-keramika posebnih svojstava, istraživanje odnosa sastava stakla, strukture, električnih i termičkih svojstava posebno je važno za razumijevanje procesa koji se odvijaju u tim materijalima. Cilj je predloženog istraživanja priprava novih više-komponentnih fosfatnih stakala te određivanje odnosa između dvije osnovne vrste nositelja naboja, iona i elektrona, prisutnih u odabranim staklima i staklo-keramikama. Predloženi je projekt podijeljen na tri osnovna, međusobno povezana, koraka. 1. U prvom će se dijelu istraživati mehanizmi vodljivosti u fosfatnim staklima koja pokazuju „miješanu“ elektronsko-ionsku vodljivost. 2. Drugi dio uključuje istraživanje utjecaja „miješanih“ staklotvoraca na električne procese kod fosfatnih stakala.  3. U trećem će se dijelu istraživati utjecaj kontrolirane kristalizacije na električni prijenos u odabranim modelnim sustavima iz koraka 1 i 2. Nastajanje kristalnih zrna u staklenoj matrici može promijeniti električnu vodljivost i dielektična svojstva stakla. Temeljna je ideja projekta sustavno istraživanje koje će pridonijeti razumijevanju dinamike prijenosa naboja (iona i elektrona) u staklima i staklo-keramici s različitim udjelom kristalnosti (od potpuno amorfnih do potpuno kristaliziranih). Osnovni je cilj odrediti pokazuju li uvijek ionsko-elektronska stakla i stakla koja sadrže više staklotvoraca, efekt ionsko-elektronske vodljivosti odnosno efekt „miješanih“ staklotvoraca što predstavlja univerzalno obilježje.  Međudjelovanje staklotvoraca i modifikatora mreže te nastajanje veza među njima osnovni su čimbenici koji utječu na električna svojstva stakala. Osim što je istraživanje mehanizama vodljivosti u odabranim sustavima važno s akademskog gledišta, odabrani sustavi pokazuju široke mogućnosti u primjeni kao novi elektroliti.]]></summary_hr><summary_en><![CDATA[Considerable demands of modern technology for new materials with specific properties have raised many possibilities for the investigation of glasses and glass-ceramics. Preparation of new glass and glass-ceramics with characteristic properties and the investigation of relationships among compositions, structure, electrical and thermal properties are important for understanding the mechanisms involved in these materials. The objectives of the proposed research is to prepare novel multi-compositional phosphate-based glasses, determine the correlation among both types of charge carriers, ions and electrons, present in proposed systems. In order to accomplish this, the proposed project is divided into three main interrelated steps. 1. First part will be focused on the conduction mechanisms in phosphate-based glasses that exhibit mixed electronic-ionic conduction. 2. Second part includes study of the influence of the mixed glass former effect on electrical processes in phosphate-based glasses. 3. Third part involves study of the influence of controlled crystallization on electrical transport in selected model glasses from steps 1 and 2. The formation of crystalline grains  in a glass matrix can substantially change electrical conductivity and dielectric properties of glass. The idea is to perform systematic studies for understanding the charge transport (ion and electron) dynamics in glasses and glass-ceramics with different crystallinity (from fully amorphous to fully crystallized). The main aim is to determine the universality of the mixed electronic-ionic and mixed glass former effects in proposed glasses. The interactions between glass formers and modifiers, the formation of bonds among them are essential factors that influence the electrical properties of glasses. Beyond the connection to the central theme of conduction mechanism important from academic point of view, the selected systems are all associated with their multiple applications as advanced electrolytes.]]></summary_en></project><project>
<id>3678</id><title_hr><![CDATA[Multiferoični i magnetoelektrični sustavi]]></title_hr><title_en><![CDATA[]]></title_en><user_id>2787</user_id><user_firstLast_name>Damir Pajić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-5107</code><acronim><![CDATA[FerMaEl]]></acronim><duration>01.06.2017 - 01.03.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>22816</team_members_id><team_members_names><![CDATA[ Doktorand: Pavla Šenjug ]]></team_members_names><keywords_hr><![CDATA[multiferoici, magneto-električni učinak, metalni oksidi, metalo-organske mreže, magnetizacija, polarizacija, teorija funkcionala gustoće]]></keywords_hr><keywords_en><![CDATA[multiferroics, magneto-electric effect, metallic oxides, metal-organic frameworks, magnetization, polarization, density functional theory]]></keywords_en><summary_hr><![CDATA[Multiferoici su materijali u kojima istovremeno postoje i magnetsko i električno uređenje, što je važno i za temeljnu fiziku i za primjene, poglavito zbog mogućeg vezanja dvije vrste reda. Iako mnogi materijali pokazuju posredne znakove magneto-električnog vezanja, izravne eksperimentalne činjenice mogle bi unaprijediti naše znanje o mehanizmima vezanja i postojanja dva uređenja. Stoga bi nadogradnja postojećih SQUID i VSM magnetometara omogućujući istraživanje utjecaja električnog polja na magnetizaciju, kao i izgradnja instrumentacije za mjerenje električne polarizacije  u primijenjenom magnetskom polju unutar postojećih kriostata, otvorila široke mogućnosti za magneto-električno istraživanje multiferoika. Multiferoičnost se javlja u različitim skupinama materijala, a istraživanje će biti usmjereno na one obećavajuće. Nove metalo-organske mreže vrlo su perspektivne, te ćemo raditi na njihovoj sintezi i modifikacijama, radi razumijevanja i utjecanja na njihovo magneto- električno ponašanje. Također, ne-centrosimetrični miješani metalni oksidi, kao i njihove nanočestice, pružaju široke mogućnosti  sinteze i modifikacije multiferoičnih svojstava. Predloženo multidisciplinarno istraživanje rezultiralo bi novim spojevima i izgrađenom aparaturom za potpunu magnetsku i električnu karakterizaciju potrebnu pri istraživanju multiferoika, dajući cjelovit skup eksperimentalnih činjenica upotpunjenih detaljnim teorijskim računima. Zajednički rad doveo bi do razvoja nezavisne istraživačke karijere i nastanka nove istraživačke skupine, jačajući suradnju i izobrazbu. Sveukupno bi omogućila plodno okruženje za kompetitivnu uključenost u istraživanja na svjetskoj razini unutar te aktualne teme u fizici čvrstog stanja i znanosti o materijalima, okupljanjem ljudskih i drugih znanstvenih resursa oko proizvodnje novih multiferoičnih sustava te njihovog cjelovitog eksperimentalnog i teorijskog proučavanja.]]></summary_hr><summary_en><![CDATA[Multiferroics are materials where the magnetic and electric orders coexist, being important for fundamental physics and applications, especially due to possible coupling of the two orders. While many materials show the indirect signs of the magneto-electric coupling, the direct experimental evidences could still improve our knowledge about mechanisms of the coupling and coexistence of two orders. Therefore, the upgrade of the existing SQUID and VSM magnetometers enabling investigation of influence of the electric field onto the magnetization, and also build up of instrumentation for measurement of electric polarization in applied magnetic field, would open large possibilities for magneto-electric research of the multiferroics. Multiferroicity appears in different groups of materials and investigation would be focussed on especially promising. New metal-organic frameworks are very perspective, and we will be working on their synthesis and modifications, in order to understand and influence their magneto-electric behaviour. Further, non-centrosymmetric metallic oxides, as well as their nanoparticles, offer large possibilities for the synthesis and modification of multiferroic properties. Proposed multidisciplinary research would result with the novel compounds and installed equipment for complete magnetic and electric characterization needed in research of multiferroics, giving integral set of experimental results, supplemented with detailed theoretical calculations. Joint work would lead to development of the independent research careers and growth of new team, strengthening the collaboration and education. It would enable the fertile environment for the competitive involvement in the research at international level within this state-of-the-art topic of condensed matter physics and materials science, because of assembling the human and other scientific resources around production of the new multiferroic systems and their complete experimental and theoretical study.]]></summary_en></project><project>
<id>3681</id><title_hr><![CDATA[Genomski i glikanski biomarkeri PTSP-a]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1306</user_id><user_firstLast_name>Nela Pivac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-8774</code><acronim><![CDATA[GlycoGenePTSD]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>22640</team_members_id><team_members_names><![CDATA[ Doktorand: Lucija Tudor ]]></team_members_names><keywords_hr><![CDATA[PTSP, N-glikani, epigenetika, GWAS, genetika]]></keywords_hr><keywords_en><![CDATA[PTSD, N-glycans, epigenetics, GWAS, genetics]]></keywords_en><summary_hr><![CDATA[Napredak u razumijevanju glikanskih funkcija i struktura može ponuditi nove biomarkere PTSP-a. Rezultati GWAS studija kombiniranih s metodama visoke djelotvornosti, kao što su analize fluorescentno obilježenih glikana, pokazali su da su geni B3GAT1, SLC9A9, MGA5, FUT8, FUT3/FUT6 i HNF1A povezani s glikozilacijom u zdravih osoba iz Hrvatske. Određivanje plazmatskih i IgG N-glikana u PTSP-u, dodatno korigiranih za mogući genetski i epigenetski utjecaj, poboljšat će naše razumijevanje biološke osnove PTSP-a. Cilj predloženog projekta je istražiti povezanost između genetskih, epigenetskih i glikomskih mehanizama odgovornih za otpornost ili ranjivost na razvoj PTSP-a nakon izlaganja traumatskom iskustvu/iskustvima.Specifični ciljevi projekta su:1) određivanje N-glikana u plazmi i IgG-u bolesnika s PTSP-om i odgovarajućih kontrolnih ispitanika;2) potvrda specifičnih polimorfizama odabranih gena koji reguliraju glikozilaciju proteina, određenih putem GWAS studija, u bolesnika s PTSP-om i odgovarajućih kontrolnih ispitanika;3) procjena utjecaja epigenetske regulacije i ekspresije gena HNF1A na glikozilaciju proteina u bolesnika s PTSP-om i odgovarajućih kontrolnih ispitanika.Ovakav pristup će ponuditi integraciju i razumijevanje multidimenzionalnih baza podataka i identificirati nove biomarkere PTSP-a, kao i nove mete i nove strategije u prevenciji razvoja PTSP-a nakon izlaganja traumi ili u terapijskoj intervenciji u PTSP-u.]]></summary_hr><summary_en><![CDATA[The advances in understanding of glycans’ function and structure might offer new biomarkers of PTSD. The results from GWAS, combined with high throughput analysis of fluorescently labelled glycans, suggest B3GAT1, SLC9A9, MGA5, FUT8, FUT3/FUT6 and HNF1A genes to be associated with glycosylation in healthy individuals from Croatia. Determination of N-glycans associated with PTSD in plasma and from IgG, additionally corrected for a possible genetic and epigenetic influence, will improve our understanding of the biological underpinnings of PTSD. The proposed project aims to provide an association between genetic, epigenetic and glycomic mechanisms responsible for the resilience or vulnerability to develop PTSD after exposure to a traumatic event(s).The specific aims of the project are:1) determination of plasma and IgG N-glycans in patients with PTSD and in matched control subjects;2) confirmation of the polymorphisms in the specific selected genes which regulate protein glycosilation, determined by GWAS, in patients with PTSD and in matched control subjects; 3) evaluation of the influence of epigenetic regulation and expression of the HNF1A gene on protein glycosylation in patients with PTSD and in matched control subjects.This approach will offer integration and understanding of the multidimensional dataset and identify novel biomarkers of PTSD, as well as new targets and novel strategies to prevent development of PTSD after exposure to a trauma, or for therapeutic intervention in PTSD.]]></summary_en></project><project>
<id>3684</id><title_hr><![CDATA[Univerzalne osobine sustava hladnih bozonskih i fermionskih atoma]]></title_hr><title_en><![CDATA[]]></title_en><user_id>875</user_id><user_firstLast_name>Leandra Vranjes Markic</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-9336</code><acronim><![CDATA[UniCold]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Science]]></institution_en><team_members_id>18947</team_members_id><team_members_names><![CDATA[ Doktorand: Krešimir Dželalija ]]></team_members_names><keywords_hr><![CDATA[ultrahladni plinovi, kvantni Monte Carlo, univerzalnost, nered, BEC, suprafluidnost, spin-orbit vezanje, kvantna halo stanja]]></keywords_hr><keywords_en><![CDATA[ultracold gases, Quantum Monte Carlo, universality, disorder, BEC, superfluid, spin-orbit coupling, quantum halo state]]></keywords_en><summary_hr><![CDATA[Ultrahladni plinovi nude besprimjerne mogućnosti proučavanja jako koreliranih sustava  i razmatranje izazova u različitim područjima fizike.  Pogodni su zbog podesivosti jačine  interakcija i mogućnosti kontroliranja i  istraživanja utjecaja dimenzionalnosti, neredai kvantne statistike. Omogućavaju eksperimentalno ostvarenje kako tradicionalnih modela fizike kondenzirane materije tako i novih sustava kao što su spin-orbit vezani (SOC) bozoni.Posebno su zanimljive njihove univerzalne osobine, koje omogućavaju uspostavljanje veza između fenomena na različitim skalama energije i duljine. Rezonantni režim s duljinom raspršenja jednakom nulipredstavlja univerzalnu jako interagirajuću unitarnu granicu, gdje su potrebna točna teorijska predviđanja koja uključuju efekte iznad teorije srednjeg polja. Kvantnim Monte Carlo(QMC) metodama moguće je točno riješiti višečestičnu Schrodingerovu jednadžbu za atome, molekule, tekućine, krutine i različite modele. U projektu ćemo dalje razviti metode te ih primijeniti na probleme sustava hladnih bozonskih i fermionskih atoma, s ciljem karakterizacije njihovih univerzalnih osobina. Prvo, proučit ćemo sustave malog broja čestica, fokusirajući se na realistična molekularna kvantna halo stanja, kao što su klasteri helija i alkalijskih atoma. Cilj je utvrditi mogu li se univerzalne relacije skaliranja  između energije i veličine sustava, već utvrđene na primjeru trimera, proširiti na sustave većeg broja čestica, što je važno  i za halo stanja u nuklearnoj fizici. Nadalje će se proučiti utjecaj nereda i dimenzionalnosti na univerzalne osobine bozonskih i bozonsko ferminskih mješavina u zamkama. Posebno zanimljiv je prijelaz između suprafluida i izolatora te lokalizacija suprafluidnosti i Bose-Einsteinove kondenzacije. Naposljetku, QMC metode ćemo dodatno razviti tako da uzimaju u obzir i spinove čestica, što će omogućiti proučavanje univerzalnosti i novih faza SOC plinova.                                                                                                                  ]]></summary_hr><summary_en><![CDATA[Ultracold gases provide unprecedented possibilities to study strongly correlated systems and address challenges indifferent fields of physics. The advantages they provide aretunability of interactions, possibility to control and exploredimensionality effects, disorder and quantum statistics. Theyallow the experimental realisation and study of both traditionalmodels from condensed matter physics and novel systems suchas spin-orbit coupled (SOC) bosons. Especially interesting are their universal properties, which enable establishment of connections betweenphenomena at different energy and length scales. The resonant regimeof zero-scattering length provides a universal strongly interacting unitary limit, where accurate theoretical predictions beyond mean field are necessary.  Quantum Monte Carlo (QMC) methods are able to accurately solve many-bodySchrodinger equation of atoms, molecules, liquids, solidsand different model systems. In the project we&#39;ll further developthe methods and apply them to problems in the field of coldBose and Fermi atoms, with the goal to characterize their universal properties. First, we&#39;ll study few-body systems,focusing on realistic molecular quantum halo states, such ashelium-alkali clusters. The goal is to establish whether universal scaling relations between energy and size, already established for trimers, can be established for clusters with more particles. This would provide benchmarkfor halo states in nuclear physics. Next, the effect of disorder and dimensionality on universal properties of trapped Bose-Bose and Bose-Fermi systems will be studied.Especially interesting is the superfluid-insulator transition and localization ofsuperfluidity and Bose-Einstein condensation. Finally, QMCmethods will be further developed so that spin degree offreedom is explicitly accounted for, which will allow study ofuniversality and novel phases of SOC gases.                                                                      ]]></summary_en></project><project>
<id>3688</id><title_hr><![CDATA[Optimizacija parametarski ovisnih mehaničkih sustava]]></title_hr><title_en><![CDATA[]]></title_en><user_id>935</user_id><user_firstLast_name>Ninoslav Truhar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-2914</code><acronim><![CDATA[OptPDMechSys]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Fakultet primijenjene matematike i informatike]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, School of Applied Mathematics and Informatics]]></institution_en><team_members_id>22601</team_members_id><team_members_names><![CDATA[ Doktorand: Matea Puvača ]]></team_members_names><keywords_hr><![CDATA[veliki parametarski ovisni mehanički sustavi, nelinearni svojstveni problemi, optimizacija prigušenja, optimalno upravljanje, matrične jednadžbe]]></keywords_hr><keywords_en><![CDATA[ large-scaled parameter dependent mechanical systems,  nonlinear eigenvalue problem, damping optimization, optimal control, matrix equations]]></keywords_en><summary_hr><![CDATA[Ovaj je projekt posvećen proučavanju mehaničkih sustava drugog reda opisnih sustavom običnih diferencijalnih jednadžbi čije su matrice velikih dimenzija, ovisne o jednom ili više realnih parametara. Glavnina istraživanja bit će usmjerena na: optimizaciju aktivnog i pasivnog prigušenja, optimalno upravljanje parametarski ovisnim mehaničkim sustavima sa i bez vanjske sile; opisivanje svojstava svojstvenih vrijednosti i svojstvenih vektora parametarski ovisnog pripadnog kvadratnog odnosno nelinearnog problema.Za problem optimizacije aktivnog i pasivnog prigušenja mehaničkih sustava sa i bez vanjske sile, razvit ćemo opći teorijski okvir, i konstruirati adekvatne numeričke algoritme. Ta će teorijska razmatranja biti vezana za optimizaciju raznih parametara prigušenja vezanih uz nekoliko različitih optimizacijskih kriterija. Nadalje, u okviru navedenih problema rješavat ćemo mnoge numerički zahtjevne probleme: problem mješovite cjelobrojne nelinearne optimizacije, efikasno rješavanje velikih matričnih jednadžbi (Lyapunov, Sylvester, Riccati), poboljšanje optimizacijskih algoritama redukcijom modela. Takodjer ćemo razmatrati kako teorijski tako i numerički aspekt problema optimizacije semi-aktivnog prigušenja te optimalnog upravljanja s aspekta različitih kriterija.U okviru problema opisivanja ponašanja svojstvenih vrijednosti i svojstvenih vektora parametarski ovisnog kvadratnog problema, razvit ćemo perturbacijsku teoriju za pripadni kvadratni problem, pri čemu ćemo posebno proučavati slučaj kad je pripadni linearizirani par  dijagonalizabilan, a posebno kada je par definitan. Za oba slučaja razvit ćemo pripadne perturbacijske teorije apsolutnog i relativnog tipa.Navedeni problemi su povezani tako da će nam uvid u ponašanje svojsvenih vrijednosti i pripadnih vektora omogućiti bolje razumjevanje djelovanja prigušenja ili drugih dijelova mehaničkih sustava i obratno. ]]></summary_hr><summary_en><![CDATA[This project is devoted to the second order mechanical systems described by a system of differential equations, whose coefficient matrices are large-scaled and dependent on one or more real parameters.The majority of the research within this project will be focused on: optimization of active and passive damping and optimal control of parameter dependent mechanical systems with and without external force; describing the properties of eigenvalues and eigenvectors of the corresponding parameter-dependent quadratic or nonlinear problem.Within the problem of active and passive damping optimization and optimal control of parameter dependent mechanical systems with and without external force, we will develop a general theoretical framework. These theoretical considerations will be related to the optimization of various damping parameters with respect to a several different optimization criteria. Furthermore, within the stated objectives we will solve many numerical demanding problems: mixed-integer nonlinear optimization problem, efficiently solving of large matrix equations (Lyapunov, Sylvester, Riccati), improving the optimization algorithms by dimension reduction. We will also consider theoretical and numerical aspects of optimization of semi-active damping problem and optimal control based on various criteria.Within the problem of describing the behavior of eigenvalues and eigenvectors of the parameter-dependent nonlinear eigenvalue problems, we will develop perturbation theory for the corresponding quadratic problem separately for cases when the corresponding linearized  pair is diagonalizable or definite. For both cases we will develop perturbation theory of absolute and relative type for the eigenvalues and associated eigenvectors i.e. subspaces.The all mentioned problems are closely related, thus the insight into the behavior of eigenvalues and corresponding eigenvectors will allow better understanding of the behavior of mechanical systems and vice versa.]]></summary_en></project><project>
<id>3690</id><title_hr><![CDATA[Uspostava dugoročnog znanstvenog monitoringa prirodnih šumskih ekosustava u Hrvatskoj]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3754</user_id><user_firstLast_name>Stjepan Mikac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-2593</code><acronim><![CDATA[CroFEM]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Šumarstvo, </scie_field_hr><scie_field_en>Forestry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet šumarstva i drvne tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Forestry and Wood Technology]]></institution_en><team_members_id>22826</team_members_id><team_members_names><![CDATA[ Doktorand: Domagoj  Trlin ]]></team_members_names><keywords_hr><![CDATA[ekstenzivni monitoring, intenzivni monitoring, prašume, dinamike prašuma, dugoročna promjene]]></keywords_hr><keywords_en><![CDATA[extensive monitoring, intensive, old-growth forest, forest dynamic, long-term changes]]></keywords_en><summary_hr><![CDATA[Hrvatska, u usporedbi s većinom Srednjoeuropskih zemalja, ima razmjerno prirodne šumske sa brojnim visoko vrijednim lokalitetima koji posjeduju karakter izvornih prašuma. Ideja o sustavnom multidisciplinarnom ekološkom monitoringu u Hrvatskoj pojavila se 1965. godine, no nije uspješno realizirana. Na osnovi te ideje, te potaknuto povećanjem sveukupnog interesa za praćenje promjena i dinamike prirodnih ekosustava, početkom 80-tih godina osnovane su trajne plohe po načelima UNESCO-vog programa MAB (Man and the Biosphere Programme). Nadahnuti potrebom za boljim razumijevanjem prirodne dinamike šumskih ekosustava i dugoročnim praćenjem promjena predlažemo ovaj projekt sa ciljem uspostave dugoročnog znanstvenog monitoringa, uz revitalizaciju postojećih i osnivanje novih ploha, čime će se stvoriti mreža terenskih laboratorija na kojima će sadašnji i budući znanstvenici nadograđivati svoje znanstvene kapacitete. Projektom se žele objediniti znanja i uspostaviti interdisciplinarna dugoročna istraživanja s jednim zajedničkim ciljem – razumijevanjei praćenje dinamike šumskih ekosustava. Projekt je zamišljen na dvije razine intenziteta monitoringa: 1) ekstenzivni monitoring-EM (I) i 2) intenzivni monitoring-IM (II). Ekstenzivni monitoring rezultirao bi sa 50-60 pokusnih objekata diljem Hrvatske dok bi se intenzivnim monitoringom obuhvatilo 5 najreprezentativnijih prašumskih objekata. IM treba poslužiti kao reprezentativni objekt istraživanja za sve plohe ekstenzivnoga monitoringa, dok EM omogućava procjenu u kojoj se mjeri rezultat intenzivnog monitoringa slučaja mogu generalizirati za jednaki stanišni tip, geološku podlogu, vegetacijska obilježja i slično sa relativno brzom i jeftinom izmjerom indikatora, koji pokazuju stanje ekosustava.]]></summary_hr><summary_en><![CDATA[Croatia, in comparison with most Central European countries, has a valuable forest areas with characteristics of a old-growth forest. The idea of systematic multidisciplinary, environmental monitoring in Croatia appeared in 1965. Based on these ideas, and driven by the growing interest in monitoring changes and dynamics of natural ecosystems, in early 80s the long-term, permanent monitoring plots  were established according to the principles of the UNESCO MAB program. Unfortunately, after the initial establishment, these plots were not systematically monitored. Inspired by the need for better understanding of the natural dynamics of forest ecosystems and the long-term monitoring we propose this project with the aim of establishing a long-term scientific monitoring. It  includes revitalization of existing and establishment of new monitoring plots which will,  in the end, represent a network of field laboratories where current and future researchers would build their research capacities. The project aims to consolidate knowledge and establish a long-term interdisciplinary research with one common goal – understanding and  monitoring the dynamics of forest ecosystems. The project is designed on two levels of intensity: 1) extensive monitoring-EM (I) and 2) intensive monitoring-IM (II). EM would result in the 50-60 plots across the Croatia while five of the most representative old-growth forest sites  will be the object of IM. IM should serve as a representative object of research for all plots of an EM, while EM enables the estimation of the  extent to which the results of the IM case study can be generalized for the habitat type, the geological substrate, vegetation characteristics and the like. This  by using relatively quick and inexpensive survey indicators, which show the status of ecosystem. ]]></summary_en></project><project>
<id>3691</id><title_hr><![CDATA[Kronične upalne bolesti crijeva u djece: incidencija, tijek bolesti te uloga prehrane i crijevne mikroflore u etiopatogenezi]]></title_hr><title_en><![CDATA[]]></title_en><user_id>2694</user_id><user_firstLast_name>Iva Hojsak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-9581</code><acronim><![CDATA[PED-IBD]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Clinical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>21390</team_members_id><team_members_names><![CDATA[ Doktorand: Sara Sila ]]></team_members_names><keywords_hr><![CDATA[upalne bolesti crijeva, djeca, crijevna flora, enteralna prehrana, incidencija, registar]]></keywords_hr><keywords_en><![CDATA[inflammatory bowel disease, children, enteral nutrition, incidence, registry]]></keywords_en><summary_hr><![CDATA[Etiologija i patogeneza kroničnih upalnih bolesti crijeva (IBD - inflammatory bowel disease), unatoč visokoj prevalenciji, nisu razjašnjene. Predloženi mehanizam uključuje interakciju neodgovarajućeg (aberantnog) imunološkog odgovora na crijevnu mikrofloru / crijevni sadržaj, u genetski predisponiranih osoba. Cilj je ovog istraživačkog projekta pridonijeti rasvjetljavanju navedene patogeneze.Ciljevi. 1. Prehrana. Bolesnici s IBD-om vrlo često izbjegavaju određene namirnice u prehrani, pridajući im – po njihovu bolest – neželjena svojstva. Međutim, učinak takvih samonametnutih dijeta nije do sada istražen i za takve dijetetske postupke zasad nema znanstveno utemeljnog opravdanja. Od posebne je to važnosti za djecu u koje ozbiljnije dijetetske restrikcije mogu imati dugoročne posljedice na rast i razvitak. Stoga je prvi cilj ovog projekta utvrditi učestalost samoiniciranih dijeta u djece s IBD-om i procijeniti njihov učinak na: a) nutritivni status koristeći strogo definirane parametre, b) tijek bolesti. U istraživanje će se uključiti novodijagnosticirani bolesnici s IBD-om te zdrave kontrole.2. Crijevna mikroflora. Znanstveno je potvrđena terapijska učinkovitost isključive enteralne prehrane (EEN - exclusive enteral nutrition) na aktivnu formu Crohnove bolesti (CD) u djece, koja se, dijelom, pripisuje utjecaju na crijevnu mikrofloru. Međutim, dokaza o njihovoj povezanosti zasad nema. Stoga je drugi cilj ovog istraživanja utvrditi razliku u crijevnoj mikroflori u trenutku postavljanja dijagnoze i nakon indukcije remisije sa EEN. Crijevna mikroflora bolesnika usporedit će se s crijevnom mikroflorom zdravog brata ili sestre oboljelog djeteta i to neposredno prije, i dva dana nakon početka EEN. Nadalje, u djece s CD crijevna će se mikroflora odrediti i nakon završetka EEN te svakih dva mjeseca tijekom cijele prve godine praćenja. 3. PED-IBD registar. Do sada nije utvrđena incidencija, tijek i ishod bolesti („natural history“) u djece oboljele od IBD-a u Republici Hrvatskoj. Slijedom navedenoga, treći je cilj našeg projekta utemeljiti nacionalni registar djece s IBD-om s on-line bazom podataka koja će sadržavati sve važne kliničke i dijagnostičke parametre u sve djece s novodijagnosticiranom bolesti u Hrvatskoj. Podaci o bolesniku unositi će se kod dijagnoze i nakon godine dana praćenja. Za određivanje rizičnih čimbenika za nastanak relapsa koristit će se multivarijatna analiza koja će uključiti kliničke i terapijske parametre. ]]></summary_hr><summary_en><![CDATA[The etiology and pathogenesis of inflammatory bowel disease (IBD) have not been fully elucidated. 1. Diet. Patients with IBD, despite the absence of scientific evidence, often avoid certain types of food; however the effect of those self-imposed diets has not been determined. This is especially important in children whereby insufficient diet could have long-term consequences on growth and development. Therefore, the first objective of our study is to determine the frequency of self-induced diets in children with IBD and their impact on: a) nutritional status by using clearly defined parameters and b) course of the disease. The study will include newly diagnosed patients with IBD and healthy controls. 2. Intestinal microflora. It has been hypothesized that the excellent therapeutic effect of exclusive enteral nutrition (EEN) on pediatric active Crohn&#39;s disease (CD) could be explained by the effect on intestinal microflora. However, well performed studies are lacking. Therefore, the second objective of our study is to determine the difference in gut microflora at diagnosis and after remission induction achieved with EEN. Patients’ intestinal microflora will be compared with the microflora of healthy siblings before and two days after both groups receive EEN. Furthermore, in children with CD the intestinal microflora will be determined after 6 weeks of EEN and during the first year of follow up.  3. PED-IBD Registry. The incidence and natural history of pediatric IBD in Croatia has not been determined yet. The third goal of our project is to establish a national registry of children with IBD by providing an on-line database that will contain relevant clinical and diagnostic factors on all newly diagnosed pediatric IBD patients. To achieve this goal data will be entered at diagnosis and after one year of follow up. Multivariate analysis, which will include clinical and therapeutic parameters, will be used to determine risk factors for early disease relapse.]]></summary_en></project><project>
<id>3692</id><title_hr><![CDATA[Prirodno stanište klinički značajnih Acinetobacter baumannii]]></title_hr><title_en><![CDATA[]]></title_en><user_id>419</user_id><user_firstLast_name>Jasna Hrenović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-3123</code><acronim><![CDATA[NATURACI]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>22631</team_members_id><team_members_names><![CDATA[ Doktorand: Svjetlana Dekić ]]></team_members_names><keywords_hr><![CDATA[Acinetobacter baumannii, Bakterije, Ekologija, Otpadna voda, Remedijacija, Tlo, Zeoliti]]></keywords_hr><keywords_en><![CDATA[Acinetobacter baumannii, Bacteria, Ecology, Remediation, Soli, Wastewater, Zeolites]]></keywords_en><summary_hr><![CDATA[Bakterija Acinetobacter baumannii je oportunistički patogen odgovoran za bolničke infekcije u imunokompromitiranih bolesnika, čija pojavnost dramatično raste tijekom zadnjeg desetljeća u Hrvatskoj i svijetu. Infekcije bakterijom A. baumannii se teško liječe zbog njihovih brojnih urođenih i stečenih mehanizama odgovornih za višestruku antibiotsku rezistenciju (multidrug-resistance; MDR), sposobnosti stvaranja biofilma, te dugotrajnog preživljavanja u bolnicama. Smatra se da su epidemije infekcija bakterijom A. baumannii uzrokovane isključivo kontaminacijom i prijenosom u bolničkom okruženju. MDR A. baumannii su nađene u bolničkim otpadnim vodama, ali ovakvi podaci nedostaju u Hrvatskoj. Do danas nije definirana pojavnost klinički važnih Acinetobacter spp. u prirodi niti njihov potencijal da prelaze u i/ili iz bolničkog okruženja. Potrebno je definirati prirodno stanište klinički važnih MDR A. baumannii. Postoji potreba za širim praćenjem te epidemiološkim studijama istraživanja utjecaja ljudskog otpada na rasprostranjivanje MDR A. baumannii. Cilj predloženog projekta je izolirati vijabilne MDR A. baumannii iz okolišnih uzoraka otpadne vode i tla. Okolišni izolati bit će genotipizirani te će biti određena njihova filogenetska srodnost s ljudskim izolatima kao i geni odgovorni za njihovu antibiotsku rezistenciju. Bit će određen i utjecaj ekoloških čimbenika na preživljavanje okolišnih izolata A. baumannii. Nadalje, istražit će se međudjelovanje okolišnih izolata A. baumannii i zeolita kao okolišno prihvatljivih dezinficijensa. Bit će razvijene metode i alternativni dezinficijensi na bazi prirodnih materijala za remedijaciju otpadnih voda i tla koja sadrže A. baumannii. Rezultati predloženog projekta će definirati prirodno stanište A. baumannii, te predložiti načine za smanjenje njihovog broja u zagađenom okolišu.]]></summary_hr><summary_en><![CDATA[Acinetobacter baumannii is an opportunistic pathogen responsible for nosocomial infections in immunocompromised patients, which emergence in hospital acquired infections increase dramatically over the last decade, both in Croatia and worldwide. Infections with A. baumannii are difficult to treat due to its ability to express multiple intrinsic and acquired mechanisms responsible for multidrug-resistance (MDR) to antibiotics, biofilm formation, and long-term persistence in hospitals. Outbreaks of A. baumannii infections are considered to be caused exclusively by contamination and transmission in hospital environment. MDR A. baumannii were detected in hospital wastewater, but such data are lacking in Croatia. The prevalence of clinically important Acinetobacter spp. in nature and their potential to migrate into and/or out of the hospital environments are undefined to date. The natural habitats of clinically important MDR A. baumannii remain to be defined. Larger screening and epidemiological studies should be performed to investigate the impact of human waste on the spread of MDR A. baumannii. The objective of the proposed project is to isolate viable MDR A. baumannii from the environmental samples of wastewater and soils. The environmental isolates will be genotyped and their phylogenetic relation to human isolates will be determined, as well as the profiles and genes responsible for their antibiotic resistance. The influence of ecological factors on the survival of environmental isolates of A. baumannii will be investigated. Interaction of environmental isolates of A. baumannii and zeolites as environmental friendly disinfectants will be studied. Methods and alternative disinfectants based on natural materials for the remediation of wastewater and soils containing A. baumannii will be developed. The findings of the proposed project will define the natural habitat of A. baumannii, and propose ways to reduce their numbers in contaminated environment.]]></summary_en></project><project>
<id>3693</id><title_hr><![CDATA[Sinteza i ciljana primjena metalnih nanočestica]]></title_hr><title_en><![CDATA[]]></title_en><user_id>158</user_id><user_firstLast_name>Iva Rezić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-8492</code><acronim><![CDATA[STARS]]></acronim><duration>15.12.2016 - 06.12.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Tekstilna tehnologija, </scie_field_hr><scie_field_en>Textile technology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Tekstilno-tehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Textile Technology]]></institution_en><team_members_id>22624</team_members_id><team_members_names><![CDATA[ Doktorand: Lela Pintarić ]]></team_members_names><keywords_hr><![CDATA[nanočestice, enzimi, polimeri, sol-gel proces, GEMMA, PDMA, GF-AAS, LC-MS/MS]]></keywords_hr><keywords_en><![CDATA[nanoparticles, enzymes, polymers, sol-gel process, GEMMA, PDMA, GF-AAS, LC-MS/MS]]></keywords_en><summary_hr><![CDATA[Glavni cilj projekta uspostava je interdisciplinarne međunarodne istraživačke skupine koja će sintetizirati nove metalne nanočestice pomoću ekološki prihvatljivih enzimski kataliziranih reakcija, te ih zatim nanositi na razne polimerne materijale. Metalne nanočestice imaju odlična nova elektronička, optička, magnetska, medicinska, katalitička i mehanička svojstva zahvaljujući specifičnoj površini koja izrazito ovisi o njihovoj veličini, strukturi i obliku. Predviđa se kako će globalna potražnja za nanočesticama metala i metalnih oksida porasti sa 270 tona u 2012. godini na 1700 tona u 2020. godini. Mi ćemo izolirati i primijeniti pet različitih enzima kako bi sintetizirali metalne nanočestice, odredili kinetiku i mehanizme provedenih reakcija, te zatim karakterizirali produkte reakcije uporabom “beyond-state-of-the-art“ instrumentalnih metoda (GEMMA, PDMA, MALDI-TOF-MS/MS i drugih tehnika). Provedba ovog projekta pomoći će pri osnivanju međunarodne istraživačke grupe koja će obuhvatiti teme iz područja nanotehnologije,  znanosti o materijalima, analitike i bioanalitike, a također će povećati istraživački potencijal mladih istraživača nabavkom znanstvene opreme koja je nužna za provođenje istraživanja vezanog uz sintezu i ciljanu primjenu metalnih nanočestica. Nakon nanošenja pojedinih ciljanih nanočestica na polimere, planiramo razviti nove materijale s namjenskom primjenom u ambalaži prehrambenih proizvoda i geotekstilija. Stoga će ovaj projekt podržati razvoj hrvatske prehrambene i tekstilne industrije. Nadalje, projekt će potaknuti interdisciplinarno istraživanje te omogućiti transfer znanja među istraživačkim grupama u Republici Hrvatskoj, kao i pružiti mogućnost transfera znanja studentima poslijedoktorskih, doktorskih i diplomskih studija koji će biti uključeni u projekt. Valja napomenuti kako će ovaj projekt ojačati i suradnju sa znanstvenicima europskih sveučilišta, te time poduprijeti integraciju hrvatskih znanstvenika u europski istraživački okvir.]]></summary_hr><summary_en><![CDATA[The main objective of this project is to establish international interdisciplinary research group that will synthesize new metal nanoparticles by environmental friendly enzymatic reactions and apply them on different polymer materials. Metal nanoparticles have novel electronic, optical, magnetic, medical, catalytic and mechanical properties owing to their high surface to volume ratio and the quantum size effect, which depend greatly on their size, structure and shape. Therefore a conservative estimation of the world market predicts the global consumption of metal oxide nanoparticles to rise from 270 tons in 2012 to 1700 tons by 2020. We will isolate and use five different enzymes to synthesize metallic nanoparticles, reveal the kinetics and mechanism of reactions, and characterize the products by using “beyond-state-of-the-art” instrumental methods (such as GEMMA, PDMA and MALDI-TOF-MS/MS). Implementation of this project will help establishing new interdisciplinary research group targeting problems in the fields of nanotechnology, material science and bio/analytical chemistry, as well as enhance the independent research leadership of the principal investigator by installing the scientific infrastructure necessary for research on the synthesis and targeted application of metal nanoparticles. By deposition of targeted nanoparticles on polymers, we will create new materials foreseen as food packaging materials and geotextiles. This will support the development of the Croatia’s food and textile industries. Moreover, the project will initiate interdisciplinary research with the transfer of knowledge among research groups, as well as provide the opportunity to transfer knowledge to postdoctoral, doctoral and diploma students working on this project. In addition, this project will strengthen international collaborations with scientists from other European universities, and by this support the integration of the Croatian science within the European research framework. ]]></summary_en></project><project>
<id>3695</id><title_hr><![CDATA[Detekcija objekata više razreda za pametna vozila i sigurnije ceste]]></title_hr><title_en><![CDATA[]]></title_en><user_id>361</user_id><user_firstLast_name>Siniša Šegvić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-6366</code><acronim><![CDATA[MULTICLOD]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>22805</team_members_id><team_members_names><![CDATA[ Doktorand: Petra Bevandić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Computer vision, structure from motion, object detection, image categorization, multi-body structure from motion]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Throughout the last decades we witness persistent improvement in understanding ways to make machines see. Consequently, opportunities for computer vision applications are becoming more and more abundant. Understanding dynamic traffic scenes is especially interesting due to exciting applications in the fields of smart vehicles (driver assistance, autonomous cars) and intelligent transportation systems (road safety inspection, adaptive traffic control). Nevertheless, many of these applications are out of reach since the computers are still unable to match human perception. We believe that this gap would be reduced by improving our understanding of scalable detection of multiple object classes in dynamic scenes.The task of object detection is to localize objects of interest in input images. We address detection in the most general case where the objects of interest exhibit large appearance variation. In this case the problem is often referred to as multi-class object detection. Our proposal focuses on dynamic traffic scenes acquired by a calibrated stereo rig from the driver&#39;s perspective. We propose to develop detection approaches which would combine estimated camera motion and scene structure with learned appearance features, and to experimentally compare them with the state of the art. We shall employ advanced methodologies such as SfM, dense stereo, variational optimization, scene flow, spatio-temporal descriptors, latent SVM and Fisher vectors. These methodologies shall enable us to achieve improvements upon the state of the art in terms of scalability and detection performance. This will open way to exciting applications capable of reducing traffic accidents, improving efficiency and decreasing traffic congestion. Some of these applications shall be demonstrated by experiments on a real autonomous car. The proposed research would also contribute to a future unified theory of computer vision which would encompass detection, reconstruction and categorization.]]></summary_en></project><project>
<id>3696</id><title_hr><![CDATA[Novi metal-organski sustavi s oksalatnim i kinoidnim ligandima s podešenim svojstvima pogodnim za primjenu]]></title_hr><title_en><![CDATA[]]></title_en><user_id>12831</user_id><user_firstLast_name>Marijana Jurić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-6941</code><acronim><![CDATA[NMOSBOQLWTPSFP]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>21308</team_members_id><team_members_names><![CDATA[ Doktorand: Lidija Kanižaj ]]></team_members_names><keywords_hr><![CDATA[funkcionalni materijali, kristalno inženjerstvo, kristalna struktura, magnetska svojstva, koordinacijski polimeri, miješani oksidi, oksalati, kinoni]]></keywords_hr><keywords_en><![CDATA[functional materials, crystal engineering, crystal structure, magnetic properties, coordination polymers, mixed metal oxides, oxalates, quinones]]></keywords_en><summary_hr><![CDATA[Cilj projekta je učinkovit i postupan dizajn novih i naprednih funkcionalnih materijala temeljenih na metal-organskim kompleksima. Kombinacijom metalnih centara s polidentatnim organskim ligandima dobivaju se strukturno raznolike rešetke različitih magnetskih električnih, termičkih, optičkih i drugih svojstava. U predloženom projektu, dva analogna premošćujuća liganda, oksalat i supstituirani 2,5-dihidroksikinonat (DHQ), koristit će se u pripravi koordinacijskih polimera različite dimenzionalnosti i topologije. Njihove interakcije s prijelaznim metalnim kationima obuhvaćaju različita magnetska svojstva, koje se mogu mijenjati izborom točno određenih strukturnih fragmenata. Oksalatni kompleksi će se istraživati ne samo kao mogući magnetski materijali s uređenjem pri određenoj temperaturi, nego kao i prekursori za pripravu tehnološki važnih miješanih metalnih oksida termičkom razgradnjom u jednom koraku. Ova metoda priprave oksida, u odnosu na standardne reakcije u čvrstom stanju, ima nekoliko prednosti: kraća termička obrada na nižoj temperaturi, nema ponavljanja postupaka mljevenja, a produkti su homogeniji. DHQ-kompleksi proučavat će se zbog njihovog potencijala za prijenos naboja, što bi moglo dovesti do materijala s reverzibilnim magnetskim prijelazom. Također, obećavajuća skupina liganada su stabilni semikinonski radikali, dobiveni iz različito supstituiranih DHQ-ova. Njihovi su kompleksi s prijelaznim metalima do sada malo poznati i nisu bili korišteni za izradu funkcionalnih materijala. Interdisciplinarnost projekta zahtjeva različite metode za karakterizaciju ovih naprednih materijala: difrakciju rendgenskih zraka na monokristalu i prahu, uključujući određivanje gustoće naboja, termičku analizu (TG / DTA), IR-, UV/Vis- i EPR-spektroskopiju, itd. Dobiveni će se rezultati koristiti za povezivanje njihovih struktura i svojstava.]]></summary_hr><summary_en><![CDATA[The project targets at efficient and progressive design of novel and advanced functional materials based on metal-organic complexes. Combination of metal centres with polydentate organic ligands provide colossal, structurally-diverse, platforms possessing a variety of magnetic, electrical, thermal, optical and other properties. In the proposed project, two analogue bridging ligands, oxalate and substituted 2,5-dihydroxyquinonate (DHQ), will be used in the preparation of the coordination polymers of different dimensionality and topology. Their interactions with transition metal cations involve a variety of magnetic phenomena, which can be tuned by highly sensitive selection of structural fragments. The oxalate-based complexes will be studied not only as potential magnetic materials ordering at a certain temperature, but also as the single-source precursors for the preparation of technologically important mixed-metal oxides through the thermal decomposition process. This method of preparing oxides, as compared to conventional solid-state reactions, has several advantages: shorter thermal treatment at lower temperature, without repeating grinding procedures, and the products are more homogeneous. The DHQ complexes will be studied due to their potential for charge transfer, which may lead to materials with reversible magnetic transition. Also, promising class of the ligands are stable semiquinone radicals derived from variously substituted DHQs. So far, their complexes with transition metals are little-known and have not been exploited for design of functional materials.The interdisciplinary nature of the project requires a variety of methods to characterise these advanced materials: single-crystal and powder X-ray diffractions including X-ray charge density studies, thermal analyses (TG/DTA), IR, UV/Vis and EPR spectroscopies, etc. The results obtained will be used to correlate their structure and properties.]]></summary_en></project><project>
<id>3697</id><title_hr><![CDATA[Nanokompoziti cinkovog oksida i titanijevog dioksida za fotonaponsku primjenu]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3922</user_id><user_firstLast_name>Andreja Gajović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-6633</code><acronim><![CDATA[ZOTONanoPhotovolt]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>22641</team_members_id><team_members_names><![CDATA[ Doktorand: Ivana Panžić ]]></team_members_names><keywords_hr><![CDATA[cinkov oksid, titanijev dioksid, nanokompoziti, fotonaponski uređaji, kemijske metode, magnetronsko rasprašivanje,  pulsna laserska depozicija]]></keywords_hr><keywords_en><![CDATA[zinc oxide, titanium diokside, nanocomposites, photovoltaic solar cells, chemical methods, magnetrons sputtering and pulsed laser deposition]]></keywords_en><summary_hr><![CDATA[Istraživat će se mogućnosti modificiranja svojstava tankih filmova metalnih oksida, prvenstveno ZnO  i TiO2, podešavanjem njihove nano-strukture i aktiviranjem njihove površine. Svojstva će se optimirati primarno za upotrebu u fotonaponskim uređajima no rezultati će biti primjenjivi i za druge opto-električne uređaje, razne vrste senzora, katalizatora itd. Pri tom će se određivati korelacija (nano)strukturnih osobina sa optičkim, vibracijskim i električnim osobinama s jedne strane te ovisnost strukture o parametrima formiranja sa druge. Ovo će omogućiti provjeru teoretskih predviđanja vezanih za defekte i nisko-dimenzionalne strukture i modeliranje rasta tankih filmova. Nastojat će se realizirati nano-strukture koje su izdužene u smjeru okomitom na površinu,  sastoje se od jedne vrste oksida a dekorirane su drugom vrstom oksida. Od njih se očekuje značajno povećanje efikasnosti fotonaponskih ćelija. Tehnike priprave će biti: (i) kemijske metode, (ii) vakuumske depozicije pomoću magnetronskog rasprašivanja i pulsne laserske depozicije (PLD). Kemijske metode (uključujući sol-gel tehnike i hidrotermalnu sintezu) ostavljaju velike mogućnosti u formiranju raznih nano-struktura (npr. nano-kristali, nano-žice, nano-plohe, nano-cjevčice) i olakšavaju veću fleksibilnost pri optimizaciji priprave te bolju statistiku u određivanju povezanosti  nano-strukture sa svojstvima. S druge strane, fotonaponske solarne ćelije podrazumijevaju formiranje slojeva na velikim površinama pa razne tehnike formiranja kao što su magnetronska depozicija i PLD imaju evidentnu prednost. Također, obrada površine plazmom je prirodno povezana sa magnetronskom depozicijom i PLD. Zbog toga će se posebna pažnja posvetiti ovim dvjema tehnikama. Optimalne strukturna svojstva, koji će se eksperimentalno potvrditi kombinacijom kemijskih metoda, će se nastojati postići magnetronskom depozicijom i PLD.Projekt će dijelom bit posvećen edukaciji doktorskih i postdoktorskiih studenta. ]]></summary_hr><summary_en><![CDATA[The possibility of modification the properties of thin film metal oxides , primary ZnO and TiO2,  by adjusting nano-structure and by activation of surfaces will be explored. The properties will be primary adjusted for use in photovoltaic solar cells while results will be applicable for other opto-electronic devices, sensors, catalysts etc.Project activities assume study of correlation between details of (nano)structural properties with optical, vibrational and electrical from one side and correlation between structure and parameters of deposition from other side. This will enable test of theoretical predictions related to defects and low dimensional structures and models of thin film growth as well. The main challenge is nano-structures elongated in the direction perpendicular to the surface, based on one type of oxide while decorated with other type of oxide. By using these structures significant increase the efficiency of photovoltaic cells is expected.Two basic preparation techniques will be used: (i) chemical methods and (ii) vacuum deposition by magnetrons sputtering and pulsed laser deposition (PLD). The chemical methods (including sol-gel technique and hydrothermal syntheses) enable relatively simple formation of various nano-structures (e. g. nano-crystals, nano-wires, nano-sheets, nano-tubes) providing larger flexibility for optimization of the preparation, and better statistics for understanding the correlation between nano-structure and properties. On the other hand, photovoltaic solar cells assume deposition of the films on large areas and for this purpose magnetron sputtering and PLD seem more suitable. Furthermore, the surface modification by plasma treatment looks appealing in combination with vacuum deposition techniques or PLD. That is why the optimal structural properties found by chemical methods will be goal to be obtained by magnetron sputtering or PLD techniques. Project will be partially devoted to education of the PhD and Postdoc. students.]]></summary_en></project><project>
<id>3699</id><title_hr><![CDATA[Održivi razvoj inovacije u hrani - valorizacija otpada masline]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3927</user_id><user_firstLast_name>Dubravka Vitali Čepo</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-5489</code><acronim><![CDATA[NutriOliWa]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Farmacija, </scie_field_hr><scie_field_en>Pharmaceutical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Farmaceutsko-biokemijski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Pharmacy and Biochemistry]]></institution_en><team_members_id>21381</team_members_id><team_members_names><![CDATA[ Doktorand: Sanja Jurmanović ]]></team_members_names><keywords_hr><![CDATA[otpad masline, održivi razvoj,  dodatak prehrani, antioksidans, bioraspoloživost, polifenoli]]></keywords_hr><keywords_en><![CDATA[olive waste, sustainable development, antioxidant, food supplement, bioavailability, polyphenols]]></keywords_en><summary_hr><![CDATA[Direktno odlaganje u okoliš otpada koji zaostaje nakon proizvodnje maslinovog ulja, veliki je ekološki problem. Ponovno iskorištavanje otpada masline u samom je začetku te njen potencijal, kao polazne sirovine, još uvijek nije ni izbliza iskorišten. Polifenoli u otpadu masline prepoznati su kao visokovrijedni spojevi no usprkos velikom broju bioloških učinaka, njihova primjena u područjima funkcionalne hrane i dodataka prehrani kao i daljnja istraživanja njihove bološke učinkovitosti vrlo su ograničena. Glavnih razlozi tome su nedostatak prihvatljivih metoda izolacije; te loša kvaliteta i karakterizacija postojećih ekstrakta što dodatno ograničava njihovu širu primjenu i istraživanje. Stoga su glavni ciljevi projekta:1. razviti učinkovit i ekološki prihvatljiv postupak ekstrakcije polifenola iz komine masline korištenjem suvremenih, nekonvencionalnih tehnika kao što su primjena ultrazvuka ili mikrovalova, zasebno ili u kombinaciji s procesom mikroenkapsulacije. 2. razviti inovativne i održive protokole formulacije visokokvalitetnog krutog ekstrakta korištenjem inovativnih tehnoloških i metodoloških pristupa 3. provesti funkcionalnu karakterizaciju dobivenih ekstrakata korištenjem suvremenih in vitro metodoloških pristupa (antioksidacijska aktivnost u modelima hrane, bioraspoloživost, apsorpcija i metabolizam polifenola iz čvrstih ekstrakta, biološka učinkovitost) Osim što će pružiti nove znanstvene spoznaje te mogu poslužiti kao izvrstan temelj za daljnja znanstvena istraživanja specifičnih bioloških učinaka, rezultati ovog projekta nalaze i vrlo konkretnu primjenu u okvirima prehrambene- i farmaceutske industrije. U širem smislu, rezultati ovog projekta pružit će bitan doprinos kvaliteti upravljanja otpadom iz agro-prehrambenog sektora što će rezultirati značajnom ekološkom i ekonomskom korišću u budućnosti.  ]]></summary_hr><summary_en><![CDATA[The olive oil industry gives place to vast amounts of residues and when discarded untreated directly to the environment, they present a major ecological issue. Although some of these residues are beginning  to be managed to a certain extent, higher benefits should be obtained from these materials. Polyphenols abundant in olive waste have been recognized as compounds of high added value but due to the lack of efficient methods of isolation; significant variations in quality of available extracts and lack of their chemical characterization, the possibilities of further investigation of their health related properties  and utilization in the segment of functional foods or dietary supplements is very limited. The major goals of this projects are:1. to develop sustainable procedure for the extraction of polyphenols from olive waste by using unconventional extraction techniques such as ultratrasound- and microwave assisted extraction, alone or in combination with microencapsulation. That should provide significant advantages over the traditional extractions methods 2. to develop efficient drying procedure for obtaining crude olive pomace extracts (COPE) using contemporary methodological approaches with satisfactory physico-chemical properties, organoleptic characteristics and increased shelf-life. 3. to provide functional characterization of COPE using contemporary methodological approaches (bioavailability and absorption of active compounds from COPE, antioxidant activity in food model systems and biological activity)In addition to providing novel scientific knowledge and serve as the excellent starting point for further scientific investigations of particular biological activities, the results of this project have great potential to be further used by food- and pharmaceutical industry. Also, in broader sense, obtained results will contribute to the meaningful management of olive mill waste resulting with both economical and ecological benefit in the future.]]></summary_en></project><project>
<id>3701</id><title_hr><![CDATA[Minimalni umjetni enzimi: Proširenje primjene &#39;&#39;posredne indukcije&#39;&#39; na nove supstrate i nove asimetrične reakcije]]></title_hr><title_en><![CDATA[]]></title_en><user_id>355</user_id><user_firstLast_name>Srećko Kirin</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-2072</code><acronim><![CDATA[MArtEn]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>21301</team_members_id><team_members_names><![CDATA[ Doktorand: Saša Opačak ]]></team_members_names><keywords_hr><![CDATA[aminokiseline, asimetrična kataliza, bioanorganska kemija, koordinacijska kemija, supramolekulska kemija]]></keywords_hr><keywords_en><![CDATA[Amino Acids, Asymmetric Catalysis, Bioinorganic Chemistry, Coordination Chemistry, Supramolecular Chemistry]]></keywords_en><summary_hr><![CDATA[Svrha ovog projekta je razvoj kiralnih katalizatora prijelaznih metala s posebnim naglaskom na inspiraciju iz prirode. Predložena je struktura beta-okreta kao ključno obilježje kiralnih katalizatora koji oponašaju umjetne enzime s minimalnom, ali fukcionalnom kiralnom vanjskom koordinacijskom sferom. Ovi minimalni umjetni enzimi mogli bi naći primjenu u asimetričnoj sintezi lijekova ili međuprodukata lijekova proizvedenih u farmaceutskoj industriji.U asimetričnoj katalizi opće je prihvaćeno da kiralna informacija mora biti prisutna što bliže koordinacijskoj sferi katalitičkog metala. Mi propitujemo ovo važno načelo i koristimo katalitički metalni centar koji je samo prokiralan. Kiralna informacija se prenosi &#39;&#39;posrednom indukcijom&#39;&#39; putem vodikovih veza udaljenih aminokiselina koje predstavljaju vanjsku koordinacijsku sferu. Preliminarni rezultati snažno podržavaju izvodljivost projekta, jer pokazuju da jednostavni biokonjugati monodentatnih trifenilfosfanskih liganada mogu tvoriti supramolekulske L2M komplekse s Rh(I) koji selektivno kataliziraju modelnu reakciju asimetričnog hidrogeniranja sa značajnim utjecajem redosljeda udaljenih aminokiselina na selektivnost [Kirin and Kokan, RSC Adv. 2012, Eur. J. Org. Chem. 2013 i Organometallics 2014; e.v. do 84 %].U okviru ovog projekta, predloženo je značajno proširenje uključujući (i) uporebu novih biokonjugata liganada s fosfornim ili dušikovim donorskim atomom, (i) uporeba novih supstrata te (iii) upotreba drugih prijelaznih metala za različite asimetrične reakcije, kao što su Ru(II)-katalizirano hidrogeniranje, Pd(II)-katalizirana alkilacija i Ln(III)-katalizirana sililcijanacija.]]></summary_hr><summary_en><![CDATA[This project aims at the development of chiral transition metal catalysts with particular emphasis on inspiration taken from nature. A beta-turn structure is proposed as key feature of chiral catalysts that resemble artificial enzymes with a minimal but functional outer-coordination sphere. These minimal artificial enzymes could find applications in asymmetric synthesis of drugs or drug intermediates produced by pharmaceutical industry.In asymmetric catalysis it is well established that the chiral information should be incorporated as close as possible to the coordination sphere of the catalytic metal. We challenge this important principle and use a catalytic metal center that is only prochiral. The chirality is transmitted by &#39;&#39;backdoor induction&#39;&#39; via hydrogen bonding of distant pendant amino acids that represent the outer-coordination sphere. Preliminary results provide a proof of concept and strongly indicate that simple amino acid bioconjugates of monodentate triphenylphosphane ligands can form supramolecular L2M complexes with Rh(I) that selectively catalyze a model asymmetric hydrogenation reaction with major impact of the distant amino acid sequence on selectivity [Kirin and Kokan, RSC Adv. 2012, Eur. J. Org. Chem. 2013 and Organometallics 2014; ee’s up to 84 %].Within this project, a significant extension is proposed including (i) the use of new ligand bioconjugates with phosphorous or nitrogen donor atoms, (ii) the use of new substrates and (iii) the use of other transition metals for different asymmetric reactions, namely Ru(II)-catalyzed hydrogenation, Pd(II)-catalyzed alkylation and Ln(III) catalyzed silylcyanation.]]></summary_en></project><project>
<id>3702</id><title_hr><![CDATA[ HIBRIBRIDNE SILICIJSKE NANOSTRUKTURE ZA SENZORIKU]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3688</user_id><user_firstLast_name>Mile Ivanda</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-3271</code><acronim><![CDATA[NANOSENS]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>25427</team_members_id><team_members_names><![CDATA[ Doktorand: Daniil Zhivotkov ]]></team_members_names><keywords_hr><![CDATA[SILICIJ, NANOSTRUKTURE, SENZORI, HIBRIDNE KOMPONENTE, ORGANSKI POLUVODIČI]]></keywords_hr><keywords_en><![CDATA[SILICON, NANOSTRUCTURES, SENSORS, HYBRID COMPONENTS, ORGANIC SEMICONDUCTORS]]></keywords_en><summary_hr><![CDATA[Prijedlog projekta temelji se na našim prethodnim aktivnostima kojima smo naučili pripraviti kvalitetne uzorke nanostrukturiranog silicija. Razvili smo i ideje te stekli znanja i iskustvo za daljnje eksperimentalne tretmane uzoraka kako bi se razvila nova svojstava s ciljem veće konkurentnosti kod određenih primjena.  Projekt se bavi temeljnim fizikalnim i kemijskim svojstvima i primjeni hibridnih silicijevih nanostruktura pripravljanim elektrokemijskim jetkanjem i kemijskom depozicijom iz pare pod niskim tlakom (LPCVD). Projektni prijedlog sadrži četiri međusobno povezana istraživačka zadataka: silicijeve hibridne nanostrukture za plinske senzore;  vrlo osjetljivi detektori za infracrvenu svjetlost; površinski pojačana Ramanova spektroskopija (SERS) u prehrambenoj tehnologiji i sferni optički mikrorezonatori u molekulskoj detekciji. Predloženi zadaci projekta su međusobno povezani preko priprave hibridnih materijala na temelju jeftinog silicija kompatibilnog CMOS tehnologiji u svrhu razvoja navedenih primjena. Za realizaciju predloženih istraživačkih zadataka organiziran je istraživački tim od 14 istraživača (9 znanstvenika i 5 doktorandada) sa 2 znanstvena instituta, 2 fakulteta, 1 instituta u privatnom sektoru i 2 instituta iz inozemstva. Elektrokemijski procesi jetkanja će se koristiti za pripravu silicija s porama odgovarajućih veličina i volumena s mogućom kontrolom od nanometarske do mikrometarske veličine. Različite kemijske metode biti će primjenjene za funkcionalizaciju poroznih silicijevih struktura pri istraživanjima i razvoju detekcije plina, IR senzora i SERS spektroskopije. Nove silicijeve heterostrukture pripravljene LPCVD metodom na sfernim kvarcnim optičkim microrezonatorima istraživati će se obzirom na mogućnosti primjene u detekciji molekula. Strukturna, optička i elektronska svojstva predloženih funkcionalnih silicijskih nanostruktura istraživati će se sa gledišta temeljnih spoznaja kao i u svrhu razvoja specifičnih proizvoda visoke tehnologije potrebnih hrvatskoj industriji.]]></summary_hr><summary_en><![CDATA[The project proposal is based on our prior research activities where we learned how to prepare high quality nanostructured silicon. We have also developed ideas and gained knowledge and experience for further experimental treatments of our samples aimed on development of new properties competitive for specific applications. The project addresses fundamental physics and chemistry, properties and application of silicon hybrid nanostructures prepared by electrochemical anodisation and low pressure chemical vapour deposition (LPCVD). The project proposal consists of four interrelated research tasks: silicon/hybrid nanostructures for gas sensing; low light infrared detection; surface enhanced Raman spectroscopy (SERS) in food technology and spherical optical microresonators in low concentration molecular detection. The proposed tasks are mutually interconnected by the CMOS technology compatible materials production based on inexpensive silicon, and by the search for their specific advanced applications. For the achievement of the proposed research tasks we have organized a team of 14 researchers (9 scientists and 5 PhD students) from 2 scientific institutions, 2 faculties and 1 institution in the private sector and 2 renowned institutions from abroad. Electrochemical processes will be used for construction of tailored pore sizes and volumes in silicon that are controllable on the scale from nano- to micrometers. A number of suitable chemistries will be applied for the functionalization of porous Si surfaces for gas sensing, IR sensors and SERS spectroscopy. The novel silicon heterostructures deposited by the LPCVD method on silica spherical optical microresonators will be investigated for possible applications in molecular sensing. The structural, optical and electrical properties of such functional silicon nanostructures will be examined from the fundamental science point of view as well as for development of specific high-tech products needed by the Croatian industry. ]]></summary_en></project><project>
<id>3703</id><title_hr><![CDATA[Postupci strojnog učenja za dubinsku analizu složenih struktura podataka]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3806</user_id><user_firstLast_name>Tomislav Šmuc</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-2244</code><acronim><![CDATA[DescriptiveInduction]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>22813</team_members_id><team_members_names><![CDATA[ Doktorand: Matej Mihelčić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[machine learning, knowledge discovery, structured data, rule learning, FPGA]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[ Induction is a process of knowledge extraction from information contained in data. In our work we will concentrate on descriptive induction whose goal is to construct knowledge that enables human understanding of the data. Included are techniques for construction of user-interpretable models, segmentation of the corpus of examples, and detection of outliers. The methodology is relevant for the computer science fields known as intelligent data analysis, knowledge discovery from data, and data mining. At Rudjer Boskovic Institute we are developing machine learning algorithms for more than 15 years and we have successfully applied them in various domains including chemistry, biology, medicine, social sciences, economics, and manufacturing. With this project we want to extend the existing methodology and to implement novel techniques able to cope with data contained in complex structures. The main topic will be spatio-temporal structures but we will work also with networks of data, relational databases, and data contained in ontologies. Previous experience clearly demonstrates that complete transformation of information contained in structured data into a form that may enter the induction process is not a simple task. Our goal is to develop and implement systematic and general approaches for this conversion. The consequence will be explosion of generated data that must enter into the process of induction. Therefore, the second goal will be implementation of efficient algorithms for descriptive induction. The work includes development of novel algorithms for clustering and outlier detection in sets of unclassified examples and implementation of hardware for fast execution of rule learning algorithms. The third goal is application and evaluation of implemented algorithms in various real-life domains. The success of the complete project will be measured by the quality and usefulness of knowledge obtained in these applications.]]></summary_en></project><project>
<id>3705</id><title_hr><![CDATA[Organska zagađivala u okolišu - markeri i biomarkeri toksičnosti]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5026</user_id><user_firstLast_name>Davor Želježić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-6005</code><acronim><![CDATA[OPENTOX]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Javno zdravstvo i zdravstvena zaštita, </scie_field_hr><scie_field_en>Public health and health services, </scie_field_en><institution_hr><![CDATA[Institut za medicinska istraživanja i medicinu rada]]></institution_hr><institution_en><![CDATA[Institute for Medical Research and Occupational Health]]></institution_en><team_members_id>22614</team_members_id><team_members_names><![CDATA[ Doktorand: Vedran Mužinić Mužinić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[pesticides, organochlorine pollutants, genotoxicity, endocrine disruption, oxidative stress, cytoskeleton, environmental distribution, risk assessment]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The proposed project is based on Directive 2009/128/EC, the EU Thematic Strategy for Pesticides, and the Collegium Ramazzini Statement concerning control over pesticides and their impact on human health and the environment. The project will focus on studying two major pesticide classes with three subgroups per each: (A) insecticides (organophosphates, neonicotinoids, and pyrethroids), (B) herbicides (triazines, organophosphates, allelopathic), and persistent organochlorine pollutants under the Stockholm convention. Low concentrations corresponding to real-life exposures will be evaluated based on residential exposure levels, occupational exposure limits, acceptable daily intakes, and reference doses in appropriate cell lines and animal models. The malsegregation of chromosomes (X, Y, 9), integrity of gatekeeping genes (TP53, c-Myc), and protein structures (cytoskeleton components) will be studied within the transplacental genotoxic evaluation of selected pesticide groups. Among these, some are suspected to be endocrine disruptors. Potential effects on sex hormone levels will be assessed in neonatal rats and transfer via mother’s milk in pubertal rats. Oxidative stress will be estimated by measuring lipid peroxidation and activity of antioxidative enzymes in vitro and in vivo. We will study the processes affecting the distribution of pesticides in water/soil systems as well as the genotoxicity of their residues in soil and water. Results for low levels of pollutant exposure will serve to significantly extend the knowledge on their genotoxicity, cytotoxicity, sex endocrine disruption, mechanisms of oxidative stress, and distribution in the environment. Also, they will be used as a base for amending and adopting the Croatian National Action Plan for sustainable use of pesticides in accordance with demands postulated in Directive 2009/128/EC and the EU Thematic Strategy for Pesticides.]]></summary_en></project><project>
<id>3706</id><title_hr><![CDATA[Anisakis spp: genomska epidemiologija]]></title_hr><title_en><![CDATA[]]></title_en><user_id>132</user_id><user_firstLast_name>Ivona Mladineo</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-9360</code><acronim><![CDATA[AnGEL]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Veterinarska medicina, </scie_field_hr><scie_field_en>Veterinary medicine, </scie_field_en><institution_hr><![CDATA[Institut za oceanografiju i ribarstvo]]></institution_hr><institution_en><![CDATA[Institute of Oceanography and Fisheries]]></institution_en><team_members_id>13683</team_members_id><team_members_names><![CDATA[ Doktorand: Jerko Hrabar ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Anisakis spp., zoonosis, seroprevalence, patohistology, transcriptomic, risk analysis]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Global migration and trade of the foodstuff, climate change, novel trends in human eating habits characterised by an elevated demand for raw food, are today considered as major reasons why reports of food borne infections, especially zoonotic parasitosis, have increased in the last decade. Thus the prevention and protection against zoonotic parasites in fishery products designated for human consumption has recently become a priority. Consequently, health authorities and fishing industry have increasingly become aware of the significance of nematode genus Anisakis, which affects human health and the commercial value of fish products. Adriatic fish, marketed fresh, frozen, salted or marinated and exported to EC, are frequently rejected on the border because of Anisakis infection. Although considered one of the most significant emerging food-borne zoonosis, anisakiasis in many Mediterranean countries is still misdiagnosed or underestimated. AnGEL will deepen the knowledge on Anisakis with a multidisciplinary approach, studying the fish as paratenic, cetaceans as the final and men as accidental host. It will start by identifying anisakids species by molecular tools in picarel and damselfish, that are particular dish in culinary tradition of SE Adriatic islands where a significant level of anti-Anisakis IgE in local population was found. It will evaluate histopathological effect of the nematode in the digestive tract of the final host in order to evaluate Anisakis carcinogenic potential, as well as its transciptomic signature during migration through hosts. It will assess larval multixenobiotic resistance mechanisms helping to design more effective therapy, and measure anti-Anisakis seroprevalence in population employed in the fish processing industry by indirect ELISA. Lastly, AnGEL will encompass resulting data in a risk analysis frame, aiming to the design of measures for the safe alimentary seafood production and strengthening of risk communication to stakeholders.]]></summary_en></project><project>
<id>3707</id><title_hr><![CDATA[Razvoj evolucijskih postupaka za karakterizaciju ponašanja bioloških tkiva]]></title_hr><title_en><![CDATA[]]></title_en><user_id>11229</user_id><user_firstLast_name>Marina Franulović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-1303</code><acronim><![CDATA[BIOMAT]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, </scie_field_hr><scie_field_en>Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Tehnički fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Engineering]]></institution_en><team_members_id>22633</team_members_id><team_members_names><![CDATA[ Doktorand: Stjepan Piličić ]]></team_members_names><keywords_hr><![CDATA[biološki materijali, karakterizacija materijala, materijalni model, materijalni parametri, genetski algoritam]]></keywords_hr><keywords_en><![CDATA[biological materials, material characterization, material model, material parameters, genetic algorithm]]></keywords_en><summary_hr><![CDATA[U inženjerstvu sve se veća pažnja posvećuje poboljšanju značajki konvencionalnih i razvoju inovativnih materijala. Iako je istraživanje materijala uvelike usmjereno na metale, polimere, staklo, keramiku, kompozite itd., sve veći interes posvećuje se biološkim sustavima i materijalima (školjke, kosti, paukova svila, mišići itsl.) zbog njihovih svojstava koje uvelike nadvisuju one konvencionalnih materijala. Ponašanje i modeliranje bioloških materijala je kompleksno, ali se kao i modeliranje konvencionalnih materijala bazira na poznavanju i eksperimentalnom određivanju njihovih karakteristika. Pored materijalnog modela za opisivanje ponašanja materijala, osnovni preduvjet za modeliranje je identifikacija materijalnih parametara. Prethodno je ustanovljeno da je za identifikaciju parametara bioloških materijala potrebnih za modeliranje njihovog ponašanja preporučljivo primijeniti evolucijske metode, a posebno genetski algoritam. U okviru projekta karakterizirat će se i modelirati ponašanje vratnih ligamenata ljudske kralježnice na osnovi podataka dobivenih eksperimentima. Odabran je hiperelastični materijalni model koji se može koristiti i za kompresibilne i nekompresibilne materijale. Kako bi se na što efikasniji način dobile potrebne vrijednosti materijalnih parametara, razvit će se tehnika određivanja parametara temeljena na genetskom algoritmu. U cilju optimizacije procedure dobivanja parametara zadanog materijala, razvit će se procedura složenog genetskog algoritma te njegovi operatori, uz primjenu adekvatne funkcije cilja optimizacijskog postupka.Zbog fleksibilnosti i robusnosti predložene metodologije karakterizacije materijala, moguća je njena primjenjivost i na karakterizaciju ponašanja i drugih nekonvencionalnih i inovativnih materijala kompleksnog ponašanja. U tu svrhu prikupit će se i sistematizirati rezultati relevantnih publiciranih eksperimentalnih ispitivanja materijala te stvoriti pretpostavke za karakterizaciju drugih inovativnih materijala.]]></summary_hr><summary_en><![CDATA[In engineering great attention is paid to enhancing the properties of conventional and development of innovative materials. Although the research is largely focused on metals, polymers, glass, ceramics, composites, etc.., increasing interest is devoted to biological systems and materials (shells, bone, spider silk, muscle or similar) due to their characteristics that are significantly above those of conventional materials.Behavior and modeling of biological materials is complex, but as the modeling of conventional materials, it is based on the knowledge and experimental determination of their characteristics. To describe the behavior of materials, beside material model, the basic prerequisite is the identification of material parameters.It was found that for the identification of parameters of biological materials necessary for the modeling of their behavior, it is advisable to apply the evolutionary methods, especially genetic algorithm.In the project, the behavior of the neck ligaments of human spine will be characterized and modelled based on data obtained by experiments. A hyperelastic material model that can be used for compressible and incompressible materials is selected for that puprose. In order to more efficiently produce the required values of material parameters, a technique for determining the parameters based on genetic algorithm will be developed. In order to optimize the procedure to obtain the parameters specified materials, complex genetic algorithm and its operators will be developed, applying the appropriate objective function optimization procedure.Because of it&#39;s flexibility and robustness, the proposed methodology for the materials characterization is expected to be applicable to the characterization of other non-conventional and innovative materials of complex behavior. To this end, relevant published experimental results will be collected and systematized in order to create the basis for the characterization of other innovative materials.]]></summary_en></project><project>
<id>3709</id><title_hr><![CDATA[Razvoj održivog procesa prerade antitoksina ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>102</user_id><user_firstLast_name>Beata Halassy</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-8293</code><acronim><![CDATA[ANTI TOX NEW]]></acronim><duration>01.07.2018 - 01.12.2021</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu]]></institution_hr><institution_en><![CDATA[University of Zagreb]]></institution_en><team_members_id>25068</team_members_id><team_members_names><![CDATA[ Doktorand: Sanja Mateljak Lukačević ]]></team_members_names><keywords_hr><![CDATA[antitoksin, antivenom, proteini plazme, inaktivacija virusa, (Fab&#39;)2 fragmenti]]></keywords_hr><keywords_en><![CDATA[antitoxin, antivenom, downstream processing, virus inactivation, (Fab&#39;)2 fragments]]></keywords_en><summary_hr><![CDATA[Antitoksini su antitijela životinjskog porijekla koja se koriste za liječenje predoziranja lijekovima (digoksin), virusnih infekcija (bjesnoća), neutralizaciju bakterijskih toksina (difterija, tetanus, botulizam), i liječenje posljedica ugriza životinja životinja otrovnica (zmija, paukova, škorpiona). Antitoksini se proizvode imunizacijom životinja, većinom konja i ovaca, odgovarajućim antigenom (uzvodni dio procesa), i pročišćavanjem imunoglobulina iz hiperimune životinjske plazme (nizvodni dio procesa). Održiv proces prerade životinjskih antitoksina ima i dodatnu vrijednost kao platforma za brzu proizvodnju lijekova protiv potpuno novih bolesti (npr. ebola). Cilj istraživanja je dizajnirati i pronaći optimalne uvjete za najučinkovitiji i najkompaktniji proces pročišćavanja antitoksina na bazi postojećih znanstvenih i tehnoloških dosega. Proces ćemo dizajnirati balansirajući između rastućih regulatornih zahtjeva, iskorištenja procesa (što viši) i troškova pročišćavanja (što niži). Cilj je pronaći optimalne uvjete za svaki korak pročišćavanja, istražiti učinkovitost cijelog postupka u redukciji rizika od virusne kontaminacije, i prikupiti podatke na laboratorijskoj razini koji mogu biti baza za proračune prilikom donošenja odluke za uspostavu pogona održive proizvodnje antitoksina. Istraživat ćemo po prvi put primjenjivost istovremenog taloženja i pepsinske razgradnje konjske plazme, što je pokazano za plazmu ovaca, i učinkovitost navedenog koraka u redukciji rizika od virusne kontaminacije, što još nije istraživano. Također, po prvi puta istražit ćemo primjenjivost kromatografije na monolitnim nosačima u postupcima pročišćavanja antitoksina.]]></summary_hr><summary_en><![CDATA[Antitoxin is the general name for the antibodies of animal origin used to treat for example drug overdose (digoxin), bacterial toxins (diphtheria, tetanus and botulism), viral infections (rabies) and envenoming (snake, spider and scorpion). So antitoxins are produced by immunisation of animals, mostly horse and sheep, by appropriate antigen of interest (upstream part of the process), and subsequent purification of induced immunoglobulins from the hyperimmunised animal plasma (downstream part of the process). Established cost-effective antitoxin production has an additional value serving as a platform that can be easily adapted for fast production of therapeutics to combat new emerging diseases (ebola, for example).The aim of the here proposed research is to design and optimise at the laboratory scale the most effective and most compact purification process (downstream part) based on the current scientific and technological knowledge. The process will be designed by balancing between criteria for fulfilling the growing regulatory demands, purification process yields (as high as possible) and the production costs (as low as possible). The aim is to find the optimal parameters of each purification step, to investigate the effectiveness of the designed process in reducing the risk of viral contamination, and to generate data on laboratory scale that could serve as the basis for decision making process regarding the sustainable antitoxin production plant establishment. The project will investigate for the first time the applicability of single-step simultaneous caprylic acid precipitation and peptic digestion of horse plasma, demonstrated so far only in ovine IgG purification, and the capability of this step in reducing the risk of viral contamination, that has not been investigated yet. Further on, the applicability of monolithic chromatographic supports (convective interaction media) in the process of antitoxin purification will be explored for the first time.]]></summary_en></project><project>
<id>3711</id><title_hr><![CDATA[Struktura i dinamika egzotičnih femto-sustava]]></title_hr><title_en><![CDATA[]]></title_en><user_id>11296</user_id><user_firstLast_name>Nils Paar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-6612</code><acronim><![CDATA[STRUDEF]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>12571</team_members_id><team_members_names><![CDATA[ Doktorand: Deni Vale ]]></team_members_names><keywords_hr><![CDATA[egzotične jezgre, energijski  funkcional gustoće, kolektivno gibanje, fisija, beta raspad, gibanje velikih amplituda]]></keywords_hr><keywords_en><![CDATA[exotic nuclei, energy density functional, nuclear collective motion, fission, beta decay, large amplitude motion]]></keywords_en><summary_hr><![CDATA[Osnovni cilj ovog projekta je razviti i primijeniti novi teorijski pristup, zasnovan na relativističkom nuklearnom energijskom funkcionalu gustoće (RNEDF) koji  omogućuje mikroskopski opis strukture i dinamike kvantnih sustava na femtometarskoj skali, te omogućuje precizan opis egzotičnih femto-sustava daleko od doline stabilnosti koji još nisu dostupni u eksperimentu. Radi se o jezgrama čija struktura i dinamika pokazuju egzotična svojstva, npr. veličinu i oblik vrlo različite od najbližih stabilnih jezgara, ili egzotične modove kolektivnog pubuđenja i raspada. Istraživački projekt uključuje razvoj teorijskog formalizma i pripadajućih modela na temelju RNEDF-a radi ostvarenja sljedećih ciljeva: (i) razviti pouzdanije funkcionale s unaprijeđenom efektivnom masom blizu Fermi površine i poboljšanim spin-orbit međudjelovanjem u izovektorskom kanalu, (ii) omogućiti kvantitativni opis statističke neodređenosti i korelacija između nuklearnih svojstava pomoću analize kovarijanci, (iii) opisati pobuđenja malih amplituda pomoću metode konačnih amplituda i vezanjima sa složenim konfiguracijama, (iv) nadograditi metodu generatorskih koordinata za gibanje velikih amplituda, (v) istražiti fenomene koegzistencije oblika i prijelaza između različitih oblika jezgara, (vi) proučiti strukturu i stabilnost superteških jezgara i proces fisije (vii) istražiti astrofizički značajne nuklearne procese koji uključuju slabu interakciju. Predviđen je razvoj naprednih teorijskih metoda za rješavanje izazova koje predstavljaju sadašnji i budući ubrzivači snopova nestabilnih iona, odnosno razumijevanje rijetkih jezgara daleko od stabilnosti koje igraju značajnu ulogu u sintezi svih stabilnih kemijskih elemenata koji danas postoje na Zemlji. Ključni pristup za ostvarenje znanstvenih ciljeva i povećanje prediktivne snage za opis egzotičnih femto-sustava je razvoj i primjena učinkovitih računalnih alata i metoda naprednog računarstva i njihova primjena na distribuiranim računalnim sustavima.]]></summary_hr><summary_en><![CDATA[The goal of this project is to develop and apply a novel theoretical framework, based on Relativistic Nuclear Energy Density Functional (RNEDF) that enables microscopic modeling of the structure and dynamics of quantum systems at the femtometer scale, and provides accurate predictions for exotic femtosystems far from stability that are not yet accessible in experiment. These nuclei have exotic or unusual structural and dynamical properties such as, for instance, sizes and shapes very different from their nearest stable nuclei, or exotic modes of collective excitation and decay by particle emission. The project research includes development of the framework based on the RNEDF with specific aims to (i) develop a more reliable functional with enhanced effective mass near the Fermi surface and improved spin-orbit interaction in the isovector channel, (ii) provide quantitative description of statistical uncertainties and correlations of nuclear properties using covariance analysis, (iii) to describe low-amplitude motion using finite amplitude method and couplings with complex configurations, (iv) upgrade the generator-coordinate method framework for large amplitude motion , (v) explore phenomena of shape coexistence and shape transitions, (vi) study the structure and stability of superheavy nuclei and fission process, (vii) explore astrophysically relevant nuclear processes including weak interaction. This will require the development of advanced theoretical methods to resolve the challenge posed by the current and future large-scale radioactive ion beam facilities, namely the understanding of rare nuclei far from stability that are precursors in the synthesis of all stable nuclear species on Earth. A key ingredient in achieving the theoretical goal of increased predictive power for exotic femtosystems is development and application of efficient computational tools and methods of scientific computing using distributed computer systems.]]></summary_en></project><project>
<id>3713</id><title_hr><![CDATA[Ultrazvučni sustav za određivanje parametara kompleksnih materijala u nelinearnim uvjetima rada]]></title_hr><title_en><![CDATA[]]></title_en><user_id>146</user_id><user_firstLast_name>Antonio Petošić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-3950</code><acronim><![CDATA[ULTRASNON]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>21320</team_members_id><team_members_names><![CDATA[ Doktorand: Petar Franček ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[material parameters, ultrasound, modular measurement system, nonlinear effects, effciency factor]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The main objective of this project is to develop a new measurement procedure and to construct a modular measurement system for determination of complex material parameters that are used in ultrasound (US) systems  which are working in the nonlinear conditions. The materials&#39; parameters in existing US systems used in biomedicine and industry are determined at low excitation levels assuming linear physical principles and consistent thermodynamical conditions. This is different from real operating conditions where range of applied powers and types of excitation signals is various and very often far away from linear. The neglect of these nonlinearities in active and passive materials, used in the complete US system construction process, leads to the problem of the US systems’ efficiency factor in the nonlinear driving conditions. The construction of modular measurement system with included and modified interferometry and time of flight principle with added new measurement procedure is crucial for developing novel US systems with higher electroacoustic efficiency factors. The new method is based on tracking the resonant frequency changes of the nonlinear electro-mechanical-acoustical system for determination complex material parameters. The new modular measurement system will enable exposure of materials to the US fields with various driving conditions. Tracking the resonant frequency changes of excitated loading medium sample (active piezoceramic or passive construction elements or different types of loading mediums) is novel method for determination of material parameters when nonlinear effects appear in the loading mediums. As a result of more precise constructive material parameters determination, three prototypes of US systems with probes and electronic excitation circuits for applications in biomedicine and industry, with obtained higher electroacoustic efficiency factors will be developed, constructed and tested during this project.]]></summary_en></project><project>
<id>3714</id><title_hr><![CDATA[Molekularna, epidemiolološka i klinička obilježja zaraze HIV-om u Hrvatskoj]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1084</user_id><user_firstLast_name>Josip Begovac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-4738</code><acronim><![CDATA[MEKHH/MECHC]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Clinical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>19506</team_members_id><team_members_names><![CDATA[ Doktorand: Maja Trupković ]]></team_members_names><keywords_hr><![CDATA[HIV, AIDS, supklinička ateroskleroza, podtipovi HIV-a, rezistancija, antiretrovirusni lijekovi, preživljenje]]></keywords_hr><keywords_en><![CDATA[HIV. AIDS, subclinical atherosclerosis, HIV subtypes, resistance, antiretrovirals, survival]]></keywords_en><summary_hr><![CDATA[Hrvatska ima centraliziranu skrb za osobe zaražene HIV-om, svi bolesnici se liječe u Klinici za infektivne bolesti u Zagrebu. Opći cilj projekta je nastaviti dugotrajno prikupljati kliničke, molekularne, laboratorijske i terapijske podatke u skupini bolesnika zaraženih HIV-om iz Hrvatske te: (1) procijeniti čimbenike u svezi s kliničkim, imunološkim i virusološkim tijekom zaraze HIV-om i (2) nastaviti razvijati sustav molekularnog nadzora uz definiranje promejna koje se tijekom vremena događaju u zarazi HIV-om u Hrvatskoj. Opći istraživanja uključuje prospektivno istraživanje demografskih, kliničkih, terapijskih, virusoloških i laboratorijskih podatke u osoba zaraženih HIV-om u Hrvatskoj, u svrhu određivanja dugotrajnog virusološkog, imunološkog i kliničkog ishoda kao i trendove u molekularnoj epidemiologiji zaraze HIV-om. Specifični ciljevi istraživanja uključuju također: procjenu nazočnosti supkliničke ateroskleroze u bolesnika zaraženih HIV-om koji primaju ART te ispitanika koji nisu zaraženi HIV-om, analizirati učinak prehtrambenih navika, posebno mediteranske prehrane na supkliničku aterosklerozu, odrediti učestalost subtipova HIV-a u novodijagnosticiranih bolesnika koji su se uključili u kliničku skrb u razdoblju od 2014 do 2017.g., analizirati transmisijske klastere subtipa B i non-B subtipova HIV-a, te odrediti prevalenciju i obrasce mutacija povezanih s primarnom rezistencijom HIV-a na lijekove. U istraživanje će se uključiti sve osobe koje se liječe u KIB, a dale su pismenu privolu za istraživanje. Uključiti će se osobe koje su bile u skrbi u razdoblju 1997 do 2017. Procjenjuje se da će ukupno 700-800 osoba biti uključeno u analize. Očekujemo da će rezultati ovog projekta doprinijeti unaprjeđivanju kvalitete skrbi bolesnika zaraženih HIV-om kao i razvoju strategija uspješnije prevencije zaraze HIV-om.]]></summary_hr><summary_en><![CDATA[Croatia as a centralized system of care and all HIV infected persons are treated at the University Hospital of Infectious Diseases (UHID) in Zagreb. ln general terms, the objective of the project s to continue a long-term, prospective collection of biomolecular, clinical, laboratory and therapeutic data on a cohort of HIV infected patients from Croatia in order to (1) assess the factors associated with the clinical, immunological and virological course of HIV infection and (2) continue to provide and develop a molecular surveillance system to describe temporal changes of HIV-infection in in Croatia. The primary aim is to determine the long-term virological, immunological and clinical outcome as well as trends in the molecular epidemiology of HIV infection. We will also specifically address issues such as: subclinical atherosclerosis in both HIV-infected patients taking ART and non-HIV-infected participants; the influence of food habits, specifically adherence to the Mediterranean diet on subclinical atherosclerosis; the frequency of HIV subtypes among newly-diagnosed patients entering clinical care in the period 2014-2017; transmission clusters of B and non-B subtypes; prevalence and patterns of transmitted drug resistance (TDR) to different classes of antiretroviral drug resistance in newly-diagnosed HIV-infected persons in the period 2014-2017 with the impact of transmission clusters on the prevalence of TDR. The study population will include all patients in care at UHID who provided written consent. Patient eligible for analysis were or will be seen in care at UHID from 1997 to 2017. It is estimated that a total of about 700-800 will be included into the analyses. The results of this project are expected to significantly contribute to the improvement of HIV clinical care as well as to the development of improved strategies for prevention of HIV infection.]]></summary_en></project><project>
<id>3716</id><title_hr><![CDATA[Role of Activating Transcription Factor 3 and related molecules in the activation of spinal cord endogenous stem/progenitor cells]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5326</user_id><user_firstLast_name>Miranda Mladinić Pejatović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-3441</code><acronim><![CDATA[]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Fakultet biotehnologije i razvoja lijekova]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Biotechnology and Drug Development]]></institution_en><team_members_id>19201</team_members_id><team_members_names><![CDATA[ Doktorand: Antonela Petrović ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>3717</id><title_hr><![CDATA[Supramolekulska sinteza samo-organizirajućih funkcionalnih nanomaterijala i kompleksnih kemijskih sustava]]></title_hr><title_en><![CDATA[]]></title_en><user_id>348</user_id><user_firstLast_name>Leo Frkanec</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-7592</code><acronim><![CDATA[SInFONIA]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>21266</team_members_id><team_members_names><![CDATA[ Doktorand: Tomislav Gregorić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Supramolecular Chemistry, Self-Assembly, Gels, Hydrogels, Functional Materials, Nanomaterials, Molecular Surface Recognition, Complex Chemical Systems]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The aim of this project proposal is supramolecular synthesis of self-assembled functional materials and study thus created complex chemical systems. Such systems exhibit a complex array of morphologies and dynamics and have a huge potential for new applications in areas ranging from materials science to medicine. The bottom–up synthesis of highly complex functional materials from simple modular blocks is an intriguing area of research. These hierarchically assembled systems extend beyond the individual molecule and rely on non-covalent interactions in a directed self-assembly process. Intrinsic properties of the materials can be modified by exploiting dynamic and specific uni-directional interactions among building blocks, thus allowing construction of novel supramolecular structures. These supramolecular networks belong to a novel category of soft biomaterials exhibiting attractive properties. Research in this project will include the formation of dynamic polymeric networks through molecular recognition and complex assembly formation. Self-assembly of small organic molecules is a suitable method for synthesis of organic nano-structured materials. LWM organo- and hydro-gels with oxalamide units represent construction units with high H-bonding potential; they are self-complementary, capable of unidirectional H-bonding suited for construction of self-assembled with fibrous morphology. In continuation of our previous research the attention will be focused on two main areas of research 1. nanofabrication; preparation of new materials by polymerization through cross linking the gel network or transcript to the TEOS and development of new organic materials that incorporate photoactive functional groups, and 2. bioinspired supramolecular systems for detection and degradation of fibrous supramolecular aggregates, such as Aß-protein and amyloid plaques (that are a major cause of Alzheimer’s disease) and vesicles functionalization for  surface molecular recognition studies. ]]></summary_en></project><project>
<id>3721</id><title_hr><![CDATA[Probiotici i starter kulture – površinski proteini i bakteriocini]]></title_hr><title_en><![CDATA[]]></title_en><user_id>796</user_id><user_firstLast_name>Jasna Beganović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-4303</code><acronim><![CDATA[PRO-S]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Biotehnologija, </scie_field_hr><scie_field_en>Biotechnology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Food Technology and Biotechnology]]></institution_en><team_members_id>21384</team_members_id><team_members_names><![CDATA[ Doktorand: Katarina Zorić ]]></team_members_names><keywords_hr><![CDATA[probiotici, starter kulture, bakteriocini, površinski proteini, funkcionalnost]]></keywords_hr><keywords_en><![CDATA[probiotics, starter cultures, bacteriocins, surface proteins, functionality]]></keywords_en><summary_hr><![CDATA[Svrha predloženog istraživanja je razvoj nove generacije probiotika i funkcionalnih starter kultura, detaljno okarakteriziranih, sa specifičnim svojstvima kao što je proizvodnja funkcionalnih površinskih S-proteina i bakteriocina. Od ukupno dvjesto različitih autohtonih sojeva bakterija mliječne kiseline (BMK), izoliranih iz tradicionalnih fermentiranih proizvoda u Laboratoriju za tehnologiju antibiotika, enzima, probiotika i starter kultura Prehrambeno-biotehnološkog fakulteta Sveučilišta u Zagrebu, samo pet Lactobacillus sojeva eksprimira sloj S-proteina na površini svojih stanica. Istraživanja će se provoditi s ciljem razjašnjavanja uloge S-proteina u stanicama Lactobacillus sojeva, posebno u važnim probiotičkim svojstvima, kao što su adhezija, kompetitivna ekskluzija patogena i interakcije s imunološkim sustavom domaćina. Istraživanja će također biti usmjerena na proizvodnju bakteriocina autohtonih sojeva BMK, mehanizma njihovog djelovanja i indukciju sinteze bakteriocina. Izolirani autohtoni sojevi BMK bit će dalje ispitivani obzirom na fiziološka i tehnološka svojstva važna pri odabiru funkcionalnih starter kultura. Obzirom da su tradicionalno proizvedeni fermentirani proizvodi bogat izvor novih i potencijalno zanimljivih mikrobnih sojeva poželjnih genetičkih, metabolizamskih i tehnoloških svojstava, okarakterizirani sojevi BMK, proizvedeni kao mikroinkapsulirane i liofilizirane funkcionalne starter kulture će doprinijeti kvaliteti i sigurnosti tradicionalnih fermentacijskih procesa kao i formulaciji inovativnih funkcionalnih proizvoda. Oboje je od velikog značaja za prehrambenu industriju s aspekta proizvodnje hrane s posebno definiranim funkcionalnim (probiotičkim) svojstvima.]]></summary_hr><summary_en><![CDATA[The proposed research is aimed to deliver new generation of probiotics and functional starter cultures, thoughtfully characterised and with specific features such as production of functional surface (S)-layer proteins and bacteriocins. Among more than 200 different autochthonous lactic acid bacteria (LAB) strains isolated from artisanal fermented food products in Laboratory of Antibiotic, Enzyme, Probiotic and Starter Culture Technologies, Faculty of Food Technology, University of Zagreb, only five Lactobacillus strains are found to possess S-layer proteins. This research is intended to clarify the role of S-layer proteins in cells of Lactobacillus species, particularly in important probiotic properties such as adhesion, competitive pathogen exclusion and interactions with host immune system. Researches will also be directed towards bacteriocin production by autochthonous LAB strains, mode of antimicrobial action, as well as the induction of bacteriocin production. Isolated autochthonous LAB strains will be further examined for their physiological and technological properties important during their selection as functional starter cultures. Since artisanal fermented foods are a rich source of new and potentially interesting microbial strains with considerable genetic, metabolic and technological properties, well-defined autochthonous LAB strains, produced as microencapsulated and lyophilised functional starter cultures, will contribute to safety and quality of traditional food fermentation processes and to formulate innovative functional products. Both are of great importance for the food industry in aspect of designing the food with specially defined functional (probiotic) properties.]]></summary_en></project><project>
<id>3722</id><title_hr><![CDATA[Molekularni aspekti oksidativnih procesa u stanicama]]></title_hr><title_en><![CDATA[]]></title_en><user_id>440</user_id><user_firstLast_name>Mario Vazdar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-3352</code><acronim><![CDATA[MolOxStress]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>21289</team_members_id><team_members_names><![CDATA[ Doktorand: Sanja Škulj ]]></team_members_names><keywords_hr><![CDATA[oksidativni stres, reaktivni aldehidi, membranski proteini, organska sinteza, molekulska dinamika, kvantnokemijski računi]]></keywords_hr><keywords_en><![CDATA[oxidative stress, reactive aldehydes, membrane proteins, organic synthesis, molecular dynamics, quantum chemical calculations]]></keywords_en><summary_hr><![CDATA[Cilj predloženog projekta je otkrivanje molekulskih detalja procesa vezanih za prijenos protona i oksidativni stres u mitohindrijima, organelima lociranim u stanicama koji služe za pretvorbu kisika i vanjskih izvora energije u adenozin trifosfat (ATP), u procesu oksidativne fosforilacije. Tijekom ovog procesa, osjetljiva energetska ravnoteža se održava pumpanjem protona izvan unutarnje mitohindrijske membrane uz pomoć lanca elektron-transport proteina te njihovog vraćanja unutra u procesu sinteze ATP-a pomoću ATP sintaze. Ova ravnoteža nije uvijek optimalna i posebna klasa proteina smještenih unutar unutrašnje mitohondrijske membrane, tzv. razvezujući proteini (&#39;&#39;uncoupling proteins&#39;&#39;), služe za kontrolu prijenosa protona kroz membranu.Posebna pažnja posvetit će se studiju reaktivnosti različitih reaktivnih aldehida koji se stvaraju tijekom oksidativnog stresa unutar fosfolipidnog dvosloja, prema razvezujućim proteinima. Ove štetne reakcije povećavaju aktivnost razvezujućih proteina koji dovodi i do povećanog protoka protona kroz unutrašnju mitohondrijsku membranu koja time mijenja energetsku ravnotežu unutar stanice što dovodi do raznih opasnih bolesti, poput raka, dijabetesa tipa 2 i pretilosti.Projekt će koristiti najnovije računske pristupe uz kombinaciju kvantnokemijskih računa i simulacija molekulske dinamike. Nadalje, teorijski proračuni će se nadopuniti modelnim eksperimentima gdje će se ispitati sintetizirani reaktivni aldehidi sa svrhom daljnjeg razumijevanja reaktvnosti, kao i dodatne provjere računskih rezultata.Ovo istraživanje će doprinijeti očuvanju zdravlja pružajući zajednici bolje razumijevanje osnovnih principa i mehanizama pomoću kojih opasni aldehidi reagiraju s razvezujućim proteinima. Predložit će se nove ideje s ciljem boljeg razumijevanja funkcije razvezujućih proteina, razvijanja lijekova za unaprijeđenje zdravlja te umanjivanju efekata oksidativnih procesa.]]></summary_hr><summary_en><![CDATA[The proposed project aims to unravel the molecular details of the processes connected with proton transfer and oxidative stress in mitochondria, organelles located in cells which convert oxygen and external energy supply into adenosine triphosphate (ATP) in the process of oxidative phosphorylation. During this process, a delicate energy balance is maintained between pumping of protons outside the inner mitochondrial membrane by the electron-transport chain proteins and transferring them back inside in the process of ATP synthesis by the ATP synthase. This balance is not always optimal and a special class of membrane proteins located inside inner mitochondrial membranes, called uncoupling proteins, serves as a control of the proton transfer rate through the membrane. Particular attention will be paid to the study of the reactivity of various reactive aldehydes generated during oxidative stress within phospholipid bilayers, towards uncoupling proteins. These deleterious reactions enhance the activity of uncoupling proteins resulting in the increased proton leak through inner mitochondrial membrane which in turn modifies energy balance inside the cell leading to various harmful diseases, such as cancer, type 2 diabetes and obesity. The project application uses the &#39;&#39;state of the art&#39;&#39; computational approach by combining quantum chemical calculations and molecular dynamics simulations. Also, the theoretical work is expanded with the experimental work where model compounds will be synthesized and used in model reaction systems to further understand and cross-check the simulation results. The research will endorse health by providing the community better understanding of the underlying principles and mechanisms by which deleterious aldehydes react with uncoupling proteins. The novel ideas will be proposed in order to better understand the function of uncoupling proteins, to develop drugs for improving health and to minimize effects due to oxidation processes.]]></summary_en></project><project>
<id>3723</id><title_hr><![CDATA[Liječenje neuropatske boli stimulacijom spinalnog ganglija]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4510</user_id><user_firstLast_name>Livia Puljak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-2774</code><acronim><![CDATA[NeuroMod]]></acronim><duration></duration><status>Prekinut</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Split School of Medicine]]></institution_en><team_members_id>21335</team_members_id><team_members_names><![CDATA[ Doktorand: Ivana Vuka ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[neuropathic pain, nerve injury, neuromodulation, dorsal root ganglion, ganglionic field stimulation, T-junction, microelectrode arrays]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Neuropathic pain is a debilitating disease of the somatosensory system that has a huge socio-economic impact. Numerous studies, including those from our laboratory have established that the injured dorsal root ganglion (DRG) is the important site for pathophysiologic changes that lead to development of neuropathic pain. Although DRG neurons are critical for the onset of neuropathic pain, there are no relevant clinical treatments for neuropathic pain that target this organ. With this proposal we aim to prove that neurostimulation techniques can be successfully used to manipulate neuronal function at the level of experimentally injured DRGs. In order to test this hypothesis we will construct a fully implantable neuronal stimulator for freely moving rats, devise an implantation technique and define stimulation protocols. This stimulator will be tested in rats with two types of experimentally induced nerve injury; spinal nerve ligation and carrageenan-induced inflammation model. Since this invasive procedure bears substantial risk of inflammation and other adverse neural tissue response, which can induce pain per se, we will also investigate connective tissue fibrosis and neuroinflammatory response in neural tissue of DRG and dorsal horn. The effect of the stimulation on excitability of injured DRG neurons will also be tested in vitro. Our last aim builds on our previous study in which we showed that neuronal injury may disable T-junction filtering and thereby increase the net conduction of afferent traffic. With this proposal we will test whether stimulation can modulate filtering properties of DRG T-junction. This will be addressed using recordings from injured sensory neurons of dorsal root ganglia excised from adult rats, and recently developed methodology that will allow us to electrically visualize action potential propagation in DRG neurons grown over custom microelectrode arrays.]]></summary_en></project><project>
<id>3726</id><title_hr><![CDATA[Porezna politika i fiskalna konsolidacija u Hrvatskoj]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3265</user_id><user_firstLast_name>Hrvoje Šimović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-1342</code><acronim><![CDATA[TPFCC]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, </scie_field_hr><scie_field_en>Economy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Ekonomski fakultet u Zagrebu]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Economics and Business]]></institution_en><team_members_id>22597</team_members_id><team_members_names><![CDATA[ Doktorand: Antonija Buljan ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[tax policy, tax system, tax structure, fiscal consolidation, Croatia]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The project is dealing with a tax policy problem Croatia has been tackling with in times of its fiscal consolidation as to ensure enough fiscal revenues, support long-term growth and maintain and even increase the equity of the tax system. The research starts with an extensive expert opinion survey about the state and perspectives of Croatian tax systems, which will be extended to Slovenia and Bosnia and Herzegovina in order to do relevant cross analysis of the obtained results. This survey will be followed by some public attitude surveys concerning relevant tax issues.The macroeconomic effects of fiscal consolidation measures in Croatia, with the emphasis on tax measures, will be analyzed at different government levels as well as the effects of tax structure on the economic growth. The research will be broadened to encompass other (mostly region) countries.It is expected that the research team with their in-depth tax policy analyses will pinpoint different aspects of crucial tax policy issues in Croatia with problem-solving recommendations regarding financial transaction tax, real estate tax, environmental taxation, flat tax and some other base broadening and tax expenditure issues. ]]></summary_en></project><project>
<id>3727</id><title_hr><![CDATA[Poticanje inovativnog ponašanja zaposlenika u javnom sektoru primjenom intervencija u dizajnu posla]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5575</user_id><user_firstLast_name>Tomislav Hernaus</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-8299</code><acronim><![CDATA[INPUBWORK]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, </scie_field_hr><scie_field_en>Economy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Ekonomski fakultet u Zagrebu]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Economics and Business]]></institution_en><team_members_id>22840</team_members_id><team_members_names><![CDATA[ Doktorand: Matija Marić ]]></team_members_names><keywords_hr><![CDATA[dizajn posla, inovativno ponašanje zaposlenika, intervencije posla, javna poduzeća, longitudinalno istraživanje, kvazi-eksperimenti, tjedni dnevnici]]></keywords_hr><keywords_en><![CDATA[work design, innovative work behaviour, job interventions, state-owned enterprises, longitudinal research, quasi-experiments, weekly diary study]]></keywords_en><summary_hr><![CDATA[Optimalno korištenje inovacijskog potencijala zaposlenika predstavlja glavni izazov upravljanja ljudskim potencijalima u današnjem globalnom i hiperkonkurentnom poslovnom okruženju. Nedavna istraživanja potvrdila su ulogu karakteristika posla kao ključnog prethodnika i usmjeravajućeg elementa za poticanje inovativnog ponašanja zaposlenika. Ipak, još uvijek ne znamo kako se različite karakteristike posla mijenjaju tijekom vremena, kakav je njihov međusobni odnos, koje su karakteristike najvažnije te kako ih je moguće uspješno mijenjati.Inovativno ponašanje zaposlenika posebice je važno i nedovoljno istraženo u javnim poduzećima. Nažalost, njihovi zaposlenici u velikoj mjeri su demotivirani i neproduktivni, dok su njihove organizacije neefikasne i nekonkurentne. Takvi negativni stavovi i loše radne prakse ograničavaju inovativno ponašanje i pružaju neadekvatne poslovne rezultate. Slijedom toga, svrha projekta je istražiti što potiče inovacije na razini posla. Planiramo provesti dubinsko istraživanje prakse dizajna posla u Republici Hrvatskoj. Analizirat ćemo karakteristike zadataka, socijalne i kognitivne aspekte poslova unutar četiri javna poduzeća od posebnog državnog značaja.Prilagođene intervencije posla (menadžerski, idiosinkratski dogovori, dorađivanje posla) bit će provedene u stvarnom radnom okruženju, zajedno s trofaznim longitudinalnim istraživanjem putem dnevnika i kvazi-eksperimentalnim nacrtom istraživanja. Pomoću intervencija u dizajnu posla, određene karakteristike posla bit će prilagođene i usklađene s osobnim i pozicijskim karakteristikama zaposlenika. Ostvarivanjem sklada između osobe i posla, potaknut će se inovativno ponašanje javnih zaposlenika, a time će se neizravno povećati i organizacijska inovativnost. Točnije, participativno akcijsko istraživanje osigurat će višu razinu generiranja ideja te dovesti do češćih procesnih unapređenja u promatranim javnim poduzećima, s mogućim učinkom prelijevanja i na druga javna poduzeća, a na dobrobit cjelokupnog hrvatskog gospodarstva.]]></summary_hr><summary_en><![CDATA[Optimally utilizing the innovative potential of employees has become a major human resource challenge within the global and highly competitive business environment. Recent studies have confirmed job characteristics as a critical antecedent and a driving force for innovative work behaviour. However, we still know little about how work design factors change over time, how they interact, which are the most important, and how they can be successfully changed.Innovative work behaviour is especially needed and understudied within state-owned enterprises. Their employees are largely unmotivated and unproductive, and organisations are ineffective and non-competitive. Such negative work attitudes and practices hinder innovative work behaviour and result in non-adequate business results. Therefore, the main purpose of the project is to explore the idea of what enhances innovation at the work level. We plan to carry out an in-depth research on work design in Croatia. We will analyse task-, social- and cognitive aspects of jobs within four strategically important state-owned enterprises. Tailored job interventions (e.g., managerial, I-deals, job crafting) will be used in a real life work setting, supplemented with three-way longitudinal diary study and quasi-experimental research design. Through work design interventions, particular set of job characteristics will be modified and aligned with personal- and job-related differences. By achieving a person-job fit, we will be able to foster innovative work behaviour of public employees, and thereby indirectly increase the level of organisational innovativeness. Specifically, the participatory action research applied will provide increased level of idea generation and will result in more frequent process improvements within sampled state-owned enterprises, with a potential spillover effect on other SOEs and significant benefits for the Croatian economy as a whole.]]></summary_en></project><project>
<id>3728</id><title_hr><![CDATA[SINTEZA I CITOSTATSKA ISPITIVANJA  BIBLIOTEKE NOVIH DUŠIKOVIH HETEROCIKLA]]></title_hr><title_en><![CDATA[]]></title_en><user_id>2767</user_id><user_firstLast_name>Krešimir Pavelić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-8011</code><acronim><![CDATA[SCIENcENTRY]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Biotehnologija, </scie_field_hr><scie_field_en>Biotechnology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Fakultet biotehnologije i razvoja lijekova]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Biotechnology and Drug Development]]></institution_en><team_members_id>22656</team_members_id><team_members_names><![CDATA[ Doktorand: Anja Harej ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[1,2,3-triazole-heterocycles hybrids, benzimidazoles, benzothiazoles, synthesis, cytostatic activity, in silico and docking analysis, DNA binding]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Cancer is one of the most serious health problems of a worldwide dimension. One in three of the population develops cancer at some time in their lives and one in four dies from this disease. The main problems in antitumor chemotherapy are drug resistance and side effects on normal tissues. In the recent years a tremendous growth was witnessed in synthesis and development of vast number and types of new heterocyclic antitumor agents, with an emphasis on creation of new drugs with better selectivity or activity. The latter are indeed major requirements in development of novel anticancer drugs. The proposed scientific project is highly interdisciplinary and objective-oriented with the principal aim to develop the novel lead compounds with pronounced and selective anticancer activity that would be used for further phases of drug development.To achieve the principal aim following specific tasks are foreseen. The goal of the first one is to synthesize small-compound library (Classes A–H) comprising new conjugates of pseudopurines, coumarines and quinolines with 1,2,3-triazole scaffold, N-acyclic 5-unsaturated pyrimidine derivatives, amino-, amido- and amidino substituted benzimidazole, benzothiazole and benzo[b]thieno-2-carboxamide derivatives. Molecule library will be synthesized using modern synthetic approaches such as click chemistry, palladium mediated cross-coupling, eco-friendly microwave assisted and photochemical reactions as well as classical organic synthetic methods. The aim of the second task is to predict plausible biological targets and pharmacological activities using cheminformatics/in silico analysis. The third task is to perform cytostatic evaluations based on which hit molecules with desired biological effect will be selected for structure optimization that will be subsequently carried out. Finally, the molecular mechanism studies are anticipated for the most effective compounds from synthesized N-heterocycles library.]]></summary_en></project><project>
<id>3729</id><title_hr><![CDATA[Glikozilacija plazmatskih proteina u razumijevanju dijabetesa tipa 1]]></title_hr><title_en><![CDATA[]]></title_en><user_id>11174</user_id><user_firstLast_name>Olga Gornik</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-3293</code><acronim><![CDATA[GLYCO-T1D]]></acronim><duration>16.10.2016 - 16.06.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Farmacija, </scie_field_hr><scie_field_en>Pharmaceutical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Farmaceutsko-biokemijski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Pharmacy and Biochemistry]]></institution_en><team_members_id>24884</team_members_id><team_members_names><![CDATA[ Doktorand: Najda Selak ]]></team_members_names><keywords_hr><![CDATA[glikozilacija, dijabetes tipa 1, glikom, genom, predispozicija]]></keywords_hr><keywords_en><![CDATA[glycosylation, type 1 diabetes, gycome, genome, predisposition]]></keywords_en><summary_hr><![CDATA[Glikozilacija je važna posttranslacijska modifikacija proteina koja često ima utjecaj na funkciju proteina. Proces glikozilacije je izrazito složen i reguliran mrežom gena koji su pokazali povezanost i s različitim bolestima. Glikani predstavljaju dobre potencijalne dijagnostičke alatke te doprinose razumijevanju etiologije mnogih bolesti. Značaj glikozilacije u dijabetesu tipa 1 (T1D) do sada nije istražen.T1D je oblik dijabetesa koji se javlja zbog autoimunog uništavanja stanica koje proizvode inzulin. Nedostatak brige za ove pacijente može biti letalan, stoga svako novo saznanje o ovoj bolesti predstavlja značajan doprinos. Povezivanje promjena u glikomu s genotipovima moglo bi rezultirati važnim rezultatima te potencijalno svrstati osobe u skupine bazirano na njihovim glikanskim i genomskim osobinama. Ova informacija bi se također mogla upotrijebiti za predviđanje rizika za razvoj bolesti kod pojedinca. Stoga ćemo u ovom istraživanju spojiti naša iskustva u genetičkim analizama i analitici glikana kako bismo identificirali glikanske promjene specifične za T1D za koje možemo kolerirati glikom i genom.Kako bi ostvarili cilj ovog istraživanja, analizirat ćemo glikane plazme obitelji s barem dvoje bolesnih potomaka te također zdravim potomcima. Uslijed ovisnosti glikana o godinama, roditelji neće biti uključeni u ovu studiju, pa će se tako analizirati preko 4500 dostupnih uzoraka. Za sve sudionike postoje rezultati genotipizacije.Glikani će se analizirati visokoprotočnom MALDI-TOF MS tehnologijom koja pruža pouzdanu analizu glikoma te je trenutno najsuvremenija glikoanalitička metoda.Uslijed neupitne uloge glikana u patološkim stanjima, izuzetno dobro definirane populacije izabrane za ovo istraživanje te upotrebu suvremene i osjetljive tehnologije, ovo istraživanje rezultirat će novim znanjima koja će unaprijediti razumijevanje i dijagnostiku dijabetesa tipa 1.]]></summary_hr><summary_en><![CDATA[Glycosylation is a posttranslational modification that provides great proteomic diversity and often impact protein function. This process is regulated by a network of genes, many of which show pleiotropy with different diseases. Glycans present a great potential diagnostic tool as well as contribute to the understanding of the aetiology of diseases. The importance of glycosylation in type 1 diabetes mellitus (T1D) has not been addressed by now. T1D is a form of diabetes that results from the autoimmune destruction of the insulin-producing beta cells in the pancreas. Lack of care for these patients can be lethal, so any new knowledge about the development of this disease would represent an important contribution. Integrating glycomic changes with the subjects’ known genotypes could generate powerful and important results, potentially defining groups based on their glycome and genomic characteristics. This information may also be used to predict an unaffected individual’s risk of disease. This is why, in this study, we will combine expertise in genetic analysis and analyses of plasma glycome in order to search for the glycomic changes that are specific to T1D and for which we can correlate glycome and genome.To reach the goals of this study, we will analyze plasma glycomes of families with both diabetic siblings and unaffected siblings. Due to the age-related changes in glycosylation, parents will not be included in this study, so over 4500 samples will be analysed. All these samples have their genotyping performed.Glycomes will be analysed using MALDI-TOF-MS technology, which provides reliable analysis and presents the best available glycoanalytic tool.Thus, due to the undeniable role of glycans in pathological conditions, the well characterized population selected for this study and the use of highly modern and sensitive technology, this study will result in important new insights that will advance the comprehension and management of type 1 diabetes mellitus.]]></summary_en></project><project>
<id>3730</id><title_hr><![CDATA[Fitohormoni u abiotskom stresu kupusnjača: mehanizam tolerancije i primjena]]></title_hr><title_en><![CDATA[]]></title_en><user_id>791</user_id><user_firstLast_name>Branka Salopek Sondi</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-9629</code><acronim><![CDATA[PhytoBraCro]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>17895</team_members_id><team_members_names><![CDATA[ Doktorand: Ida Linić ]]></team_members_names><keywords_hr><![CDATA[kupusnjače, suša, solni stres, auksin, hormoni stresa]]></keywords_hr><keywords_en><![CDATA[Brassica crops, drought, salinity stress, auxin, stress hormons]]></keywords_en><summary_hr><![CDATA[Biljne vrste iz porodice Brassicaceae su široko rasprostranjene povrtne kulture. Abiotički stres poput suše i povećanog saliniteta tla su primarni uzroci gubitka u poljoprivrednoj proizvodnji. Fitohormoni su ključni za prilagodbu biljaka nepovoljnim uvjetima regulirajući procese kao što su fotosinteza, aktivnosti antioksidacijskih enzima, akumulacija sekundarnih metabolita, promjene u ekspresiji gena itd. Biljni hormoni auksini djeluju kao regulatori u većini odgovora biljaka na stres kroz složene interakcije s hormonima stresa: salicilnom (SA), abscizinskom (ABA), jasmonskom (JA) kiselinom i brazinosteroidima (BRA). Cilj ovog projekta je istražiti mehanizme odgovora odabranih biljaka iz porodice krstašica na stres uzrokovan sušom i povećanim salinitetom: kineski kupus (Brassica rapa), bijeli kupus (B. oleracea var. capitata) i raštika (B. oleracea var. acephala) kroz integrativni pristup koji podrazumjeva metode mjerenja fotosinteze, biokemijske metode dijagnostike stresa, metabolomiku (analize biljnih hormona i sekundarnih metabolita), molekularna funkcionalna te aplikativna istraživanja. Poseban naglasak će biti na ulozi fitohormona auksina i interakcijama s hormonima stresa (SA, ABA, JA, BRA) u odgovoru na sušu i povećani salinitet te potencijalnim mehanizmima tolerancije. Biljni hormoni biti će analizirani UHPLC-MS/MS metodom. Sekundarni metaboliti, polifenoli i glukozinolati biti će mjereni spektrofotometrijski i UHPLC-MS/MS metodama. Funkcionalna istraživanja će biti provedena na linijama uročnjaka (Arabidopsis thaliana) koje imaju mutacije u genima odgovornim za homeostazu auksina (gh3, ilr). Rezultati analiza bioaktivnih spojeva (hormona i sekundarnih metabolita) će biti korelirani s fiziološkim i biokemijskim podatcima (parametri fotosinteze, ROS, antioksidacijski enzimi, prolin, glutation, karbonili). Biljni hormoni stresa će biti ispitani kao potencijalni biostimulatori tolerancije na sušu i povećani salinitet aplikacijom na list i tretmanom korijena.]]></summary_hr><summary_en><![CDATA[Crops from the family of Brassicaceae are commercially widely spread vegetables. Abiotic stresses such as salinity and drought are the primary causes of crop loss worldwide. Phytohormones are crucial for the plant ability to adapt to abiotic stress by mediating a wide range of adaptive responses: photosynthesis modification, increased antioxidant activities, secondary metabolites accumulation, changes in gene expression. Phytohormone auxin regulates the majority of plant stress responses through interactions with stress hormones salicylic acid (SA), abscisic acid (ABA), jasmonic acid (JA), and brassinosteroids (BRA). The aim of this proposal is to investigate the abiotic stress responses of selected Brassica crops (Brassica rapa. ssp. pekinesis, Brassica oleracea var. capitata and Brassica oleracea var. acephala) to drought and salinity stress through integrative research approach comprising biophysical methods of photosynthesis measurements, biochemical methods of stress diagnostics, metabolomics (plant hormones and secondary metabolites) and molecular functional research. Particular focus will be placed to the role of auxin and its interactions with stress hormones (SA, ABA, JA and BRA) in stress responses and potential mechanisms of tolerance. Phytohormones auxin, SA, JA, ABA and BRA will be analyzed by UHPLC-MS/MS. Secondary metabolites, polyphenols and glucosinolates will be measured by spectrophotometry and UHPLC-MS/MS. In order to shed light on auxin homeostasis in abiotic stress, functional research will be performed by using Arabidopsis thaliana lines for genes of auxin reversible conjugation (GH3 and ILR). Results of hormonal analyses will be correlated with basic physiological and biochemical parameters (photosynthesis parameters, ROS level, antioxidant enzymes, proline, glutathione, protein carbonyl level). Finally, stress plant hormones will be investigate as potential biostimulator of abiotic stress tolerance by foliar spray and root treatment.]]></summary_en></project><project>
<id>3735</id><title_hr><![CDATA[Recommender System for Service-oriented Architecture ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>7793</user_id><user_firstLast_name>Siniša Srbljić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-8617</code><acronim><![CDATA[RSOA]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>22589</team_members_id><team_members_names><![CDATA[ Doktorand: Adrian Satja Kurdija ]]></team_members_names><keywords_hr><![CDATA[sustav preporuke, arhitektura zansnovana na uslugama, kompozicije usluga, pomoć pri programskom oblikovanju, funkcijska i nefunkcijska svojstva]]></keywords_hr><keywords_en><![CDATA[recommender system, service-oriented architecture, service compositions, development assistance, functional and non-functional properties]]></keywords_en><summary_hr><![CDATA[Razvojem platformi vezanih uz računalne oblake (engl. Cloud computing) i internet stvari (engl. Internet of Things), sustavi utemeljeni na arhitekturi zasnovanoj na uslugama (engl. service-oriented architecture - SOA) dobivaju sve više na značaju. SOA je arhitekturalni stil koji pruža smjernice razvoja slabo povezanih raspodijeljenih sustava. Središnji objekt SOA-e su usluge, samostalni primjenski programi, kojima se pristupa korištenjem standardiziranih sučelja. Jedna od glavnih prednosti SOA-e jest mogućnost povezivanja više usluga u kompozitne sustave (kompozicije usluga). Unatoč jasnim prednostima, uz razvoj kompozicija usluga veže se niz poteškoća vezanih uz ostvarivanje funkcijskih i nefunkcijskih svojstava građenog sustava. Trenutni istraživački rezultati ne pružaju odgovor kako učinkovito graditi kompozicije usluga u slučaju kad su dostupni vrlo veliki imenici usluga te kad je složenost tijeka izvođenje građene kompozicije vrlo velika. 	Cilj ovog istraživačkog projekta je izraditi cjelovit sustav preporuke čija je uloga pojednostaviti izgradnju kompozicija usluga pružanjem pomoći programskim inženjerima u ostvarivanju funkcijskih i nefunkcijskih ciljeva. Naši prijašnji istraživački rezultati pokazuju da je izgradnja takvog sustava moguća. Kroz ovaj projekt cilj nam je proširiti postojeće rezultate s novim metodama preporuke posebno prilagođenim sustavima zasnovanima na arhitekturalnom stilu SOA.	U području funkcijskih ciljeva, predloženi sustav preporuke će omogućiti automatsku preporuku usluga zasnovanu na morfološkoj strukturi građene kompozicije usluga. Osim toga, sustav će primjenom tehnologija dijeljenja znanja omogućiti korisnicima da pronađu odgovarajuću ljudsku pomoć. U području nefunkcijskih svojstava, primijenit će se skup statističkih metoda za procjenu pouzdanosti atomarnih (gradivih) usluga. Zaključno, sustav će omogućiti učinkovito unapređivanje nefunkcijskih svojstva izgrađene kompozicije s obzirom na složenost tijeka izvođenja.]]></summary_hr><summary_en><![CDATA[In recent years, systems based on service-oriented architecture (SOA) have been gaining a lot of traction due to proliferation of cloud computing and Internet of Things (IoT) platforms. SOA is an architectural style that provides guidelines for development of loosely coupled distributed systems. The concept relies on services, self-contained applications which can be consumed using well-established interfaces. One of the most pronounced benefits of SOA is the ability to combine multiple services into a component-based application (service composition). Despite having clear advantages, service composition development entails issues when it comes to reaching both the required functional and non-functional application goals. Specifically the current research results do not offer an answer how to build service compositions efficiently when faced with large service repositories and very complex service workflows.	The goal of this project is to put forward a comprehensive recommender system aimed at simplifying development of service compositions by assisting developers in reaching both functional and non-functional application goals. Our previous research efforts, demonstrate that designing such a recommender is feasible. As part of this project we want to extend the preliminary research with novel recommender methods suited for SOA-based systems. Regarding functional properties, the proposed recommender is to facilitate automatic service recommendations based on the morphological structure of the constructed application. Furthermore, the recommender is to utilize knowledge sharing technologies to assist in enlisting most adequate human help. In the domain of non-functional properties, a set of methods used to determine reliability of atomic services based on statistical approaches will be applied. Finally, a method for efficient improvement of service composition’s non-functional properties will be utilized.]]></summary_en></project><project>
<id>3739</id><title_hr><![CDATA[Uloga fosfoinozitida u nastanku trombocita]]></title_hr><title_en><![CDATA[]]></title_en><user_id>35</user_id><user_firstLast_name>Antonija Jurak Begonja</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-1946</code><acronim><![CDATA[MkPI]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Fakultet biotehnologije i razvoja lijekova]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Biotechnology and Drug Development]]></institution_en><team_members_id>20883</team_members_id><team_members_names><![CDATA[ Doktorand: Ivana Bertović ]]></team_members_names><keywords_hr><![CDATA[megakariociti, trombociti, trombopoeza, endocitoza, fosfoinozitidi]]></keywords_hr><keywords_en><![CDATA[megakaryocytes, platelets, thrombopoiesis, endocytosis, phosphoinositides]]></keywords_en><summary_hr><![CDATA[Trombociti su neophodni za hemostazu te također posreduju u procesima različitih bolesti uključujući upale, metastaze, aterosklerozu. Liječenje leukemija i drugih malignih oboljenja ili transplantacije organa često dovode do smanjenja broja trombocita, te predstavljaju rizik od krvarenja. Trombociti nastaju iz citoplazme megakariocita (MK) u koštanoj srži u procesu trombopoeze. MK prolaze složen proces sazrijevanja koji vodi ka stvaranju dugih, razgranatih citoplazmatskih struktura – protrombocita. Molekularni mehanizmi koji reguliraju ove citoplazmatske promjene MK-a u velikoj mjeri su nepoznati. Naša preliminarna istraživanja pokazuju da određena vrsta fosfoinozitida (PI), fosfatidilinozitol 3-monofosfat (PI3P) ima glavnu ulogu u formiranju protrombocita u primarnim kulturama MK-a. U stanicama PI3P se nalazi u ranim endosomima i sudjeluje u endosomskom prometu. Naša je hipoteza da membranski promet reguliran PI3P-om u endocitnom putu znatno pridonosi biogenezi trombocita. Predloženi projekt istražit će točnu ulogu PI3P u stvaranju protrombocita. Koristit ćemo genetski napravljene  fluorescentne probe, tehniku koja se temelji na proteinskim domenama fuzioniranim s fluorescentnim proteinom eksprimiranim s retrovirusa, kako bi odredili lokalizaciju u stvarnom vremenu različitih PI u MK-ima i protrombocitima. Istražit ćemo kako interferencija PI3P funkcije utječe na sazrijevanje MK te utvrditi je li defekt ograničen na endosomski odjeljak. U svrhu utvrđivanja mehanizma djelovanja PI3P-a koristit ćemo genetski i farmakološki pristup kako bi ispitali je li progresija ranih u kasne endosome nužna za stvaranje trombocita. Osim toga, identificirat ćemo proteine koji vežu PI3P regulirajući endosomsku dinamiku važnu za stvaranje protrombocita. Ovo će istraživanje doprinijeti našem razumijevanju osnovnih molekularnih procesa trombopoeze koji bi mogli doprinijeti novim terapijskim strategijama u liječenju trombocitopenije.]]></summary_hr><summary_en><![CDATA[Platelets are essential for hemostasis and they also mediate diverse disease processes including inflammation, metastasis, atherosclerosis. Cancer and leukemia treatments or organ transplants often lead to reduced platelet numbers, putting patients at risk of bleedings. Platelets derive from cytoplasm of megakaryocytes (MKs) in the bone marrow in a process called thrombopoiesis. MKs undergo complex maturation process that leads towards extension of long, branched cytoplasmic structures called proplatelets that eventually release platelets. Molecular mechanisms that govern these elaborate cytoplasmic changes of MKs remain largely unknown. Based on primary MKs our preliminary studies show that one type of phosphoinositides (PIs), phosphatidylinositol 3-monophosphate (PI3P) has a major role in proplatelet formation. PI3P is concentrated in early endosomes and is involved in endosomal trafficking. Our hypothesis is that PI3P regulation of membrane traffic in the endocytic pathway contributes significantly to platelet biogenesis. This proposed project will reveal the exact role of PI3P in proplatelet formation. We will use genetically engineered fluorescent probes, a technique based on protein domains fused with fluorescent protein expressed from retroviruses, to define spatial and temporal localization of different PIs in MKs and proplatelets. We will investigate if interference of PI3P function affects MK maturation and examine if defect is confined to endosomal compartment. To determine mechanism of PI3P action we will use genetic and pharmacologic approaches to examine if progression of early to late endosomes is needed for platelet genesis. In addition, we will identify proteins  that act in concert with PI3P to regulate endosomal dynamics important for proplatelet formation. These studies will contribute to our understanding of basic molecular processes underlying thrombopoieses and might lead towards novel therapeutic strategies in treatment of thrombocytopenia.]]></summary_en></project><project>
<id>3740</id><title_hr><![CDATA[Molekularni mehanizmi alternativne raspodjele elektrona u fotosintezi]]></title_hr><title_en><![CDATA[]]></title_en><user_id>455</user_id><user_firstLast_name>Hrvoje Fulgosi</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-9583</code><acronim><![CDATA[PHOTOSYNTH]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>22598</team_members_id><team_members_names><![CDATA[ Doktorand: Anja  Rac ]]></team_members_names><keywords_hr><![CDATA[oksigena fotosinteza, kloroplasti, tok elektrona, FNR, ROS, rodanaza, sortiranje proteina, transgenične biljke, Arabidopsis thaliana]]></keywords_hr><keywords_en><![CDATA[oxygenic photosynthesis, chloroplasts, electron flow, FNR, ROS, rhodanese, protein sorting, transgenic plants, Arabidopsis thaliana]]></keywords_en><summary_hr><![CDATA[Konačni prijenos fotosintetskih elektrona s feredoksina na NADP+ odvija se putem enzima feredoksin:NADP+ oksidoreduktaze (FNR). FNR je privučen na tilakoide pomoću integralnog proteina tilakoidnih membrane sličnog rodanazama, TROL-a, i solubilnog proteina Tic62. TROL je nedavno okarakterizirala naša grupa. FNR također predstavlja poveznicu između svjetlosnih reakcija i generalnog metabolizma (kao što je fiksacija ugljika, metabolizam dušika, biosinteza masnih kiselina i klorofila). U ovom projektu pratimo sudbinu elektrona nizvodno od fotosustava I u odsustvu TROL-a. Da bismo proučili in vivo funkcije TROL-a i njegovih domena koristit ćemo genski “knock-out” i “knock-in” pristup u modelnoj biljci Arabidopsis thaliana. Naša hipoteza je da je FNR-TROL interakcija dinamičma, slična interakciji FNR-Tic62, i usklađena s mijenjanjem uvjeta osvjetljenja u okolišu. Nadalje, predlažemo da je lumenu izložena rodanazna domena TROL-a uključena u prepoznavanje redoks signala, dok je prolinom bogata pokretna spona, ispred motiva koji veže FNR za membranu, odgovorna za dinamičko vezanje FNR-a i/ili privlačenje FNR-a u različite membranske domene. Koristit ćemo razrađene biokemijske i biofizičke pristupe za kvantifikaciju stvaranja slobodnih radikala i protoka i raspodjele elektrona u različitim mutantama TROL-a. Cilj nam je pokazati da je točka grananja TROL-FNR integrirana u biljni odgovor na stress. Također, želimo pokazati da dinamičko vezanje i otpuštanje FNR-a s TROL-a može kontrolirati protok elektrona prije aktivacije puta pseudocikličkog prijenosa elektrona. Ovaj mehanizam vjerojatno nije uočen u dosadašnjim modelima toka elektrona u oksigenoj fotosintezi.]]></summary_hr><summary_en><![CDATA[In photosynthesis, final electron transfer from ferredoxin to NADP+ is accomplished by the flavo enzyme ferredoxin:NADP+ oxidoreductase (FNR). FNR is recruited to thylakoid membranes via integral membrane thylakoid rodanese-like protein TROL and soluble Tic62. TROL protein has recently been characterized by our group. FNR also represents a link between light-driven reactions and general metabolism (e.g. carbon fixation, nitrogen metabolism and fatty acid and chlorophyll biosynthesis). In this project, we address the fate of electrons downstream of photosystem I when TROL is absent. We will employ gene knock-out and knock-in approaches in the model plant Arabidopsis thaliana to study in vivo functions of TROL and its domains. We hypothesize that the interaction of FNR with TROL is dynamic, similar to FNR-Tic62 association, and in synchrony with changing environmental light conditions. Further, we propose that thylakoid lumen-exposed rhodanese domain of TROL is involved in perception of redox signals, while proline-rich swivel preceding FNR membrane attachment motif is responsible for the dynamic FNR biding and/or recruitment of FNR into different membrane domains. We will use elaborate biochemical and biophysical approaches to quantify free radical formation and electron flow and partitioning in various TROL mutants. We will aim to demonstrate that TROL-FNR branch point is integrated into plant stress responses. Finally, we want to demonstrate that the dynamic binding and release of FNR from TROL can control the flow of electrons prior to activation of the pseudo-cyclic electron transfer pathway. This mechanism may have been overlooked in present models of electron flow in oxygenic photosynthesis. ]]></summary_en></project><project>
<id>3741</id><title_hr><![CDATA[Jezična obrada u odraslih govornika]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6436</user_id><user_firstLast_name>Melita Kovačević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-8899</code><acronim><![CDATA[ALP]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Logopedija, </scie_field_hr><scie_field_en>Logopedics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Edukacijsko-rehabilitacijski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Education and Rehabilitation Sciences]]></institution_en><team_members_id>20388</team_members_id><team_members_names><![CDATA[ Doktorand: Ana  Matić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[language processing, adult and elderly population, language disorders, executive functions, linguistic aphasiology]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Adult Language Processing project is intended to address psycholinguistic and neurolinguistic aspects of the aging population in Croatia. As an installation research project it will help set up an interdisciplinary and multidisciplinary research group that would tackle all aspects of the language processing in adults and in the aging population. Clinical groups (patients with aphasias, dementias and dyslexia) will be included into the project; language breakdown in these clinical groups helps in the study of language processing in healthy adults and vice versa. It is generally assumed that the subtle changes in language processing in the aging population arise from the cognitive decay related to executive functions, not language per se. The decrease in the processing speed influences language processes that require fast execution or simultaneity. This results in a typical pattern of changes, different from the ones in clinical populations. Therefore, executive functions in these groups will be studied in order to build a comprehensive model of adult language processing. Theories of language processing (namely, Role and Reference Grammar - RRG) will be considered to define specific traces of language processing that assume fast execution or simultaneity and therefore should be the most vulnerable in aging population. These traces will be defined and described which will put Croatian into a cross-linguistic perspective in contemporary studies of linguistic aphasiology and provide coherent picture of age related changes in adult language system.  ]]></summary_en></project><project>
<id>3744</id><title_hr><![CDATA[ADAPTIVNA PARAMETRIZACIJA PROMJENJIVIH 3D GEOMETRIJA KOD OPTIMIZACIJE OBLIKA I  BEZMREŽNOG NUMERIČKOG MODELIRANJA]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3851</user_id><user_firstLast_name>Damir Vučina</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-6189</code><acronim><![CDATA[Optimal3D]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, </scie_field_hr><scie_field_en>Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Fakultet elektrotehnike, strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Electrical Engineering, Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>21278</team_members_id><team_members_names><![CDATA[ Doktorand: Anđela Bartulović ]]></team_members_names><keywords_hr><![CDATA[Adaptivna parametrizacija oblika, 3D geometrijsko modeliranje, particioniranje po značajkama, optimizacija oblika, bezmrežne metode]]></keywords_hr><keywords_en><![CDATA[Adaptive shape parameterization, 3D geometric modeling, Feature-based partitioning, Shape optimization, Meshless methods]]></keywords_en><summary_hr><![CDATA[Glavni cilj projekta je razvoj numerički efikasnog i dinamički adaptivnog parametarskog zapisa oblika koji donosi povećanu mogućnost modeliranja 3D oblika kako sam po sebi tako i za funkcije oblika u numeričkim metodama.Početni zapis oblika je oblak 3D točaka kakav se dobije sustavom digitalizacije oblika (3D optički sustav za skeniranje visoke razlučivosti). Matematička parametrizacija oblaka točaka zasnivati će se na parametarskim plohama. Integralna kao i po dijelovima povezana parcijalna parametrizacija biti će istražene i uspoređene.Proučavati će se dinamički aspekti parametrizacije. Oblik i posebno topologija objekta će se mijenjati u kvazivremenu simulacije/optimizacije. Za vrijeme procesa, rubovi i vrhovi mogu nestati, a novi se mogu pojaviti, zbog čega parametrizacija treba biti samostalno prilagodljiva na takve promjene.Proučavati će se strategije za redukciju parametarskog skupa nepoznanica na temelju dopuštenih graničnih vrijednosti pogrešaka u području značajki i na temelju ukupne normirane greške. Ove strategije uključuju prilagodljivu preraspodjelu kontrolnih točaka koristeći procedure za detekciju značajki temeljene na omjeru vlastitih vrijednosti i procjeni nagiba i zakrivljenosti. Vrednovati će se prilagodljiva podjela plohe cjelokupnog objekta na dijelove na temelju različitih kriterija.   Proces optimizacije uključuje opsežne izračune odnosno rješavanje problema polja opisanog parcijalnim diferencijalnim jednadžbama. Navedeni aspekti modeliranja oblika također se primjenjuju u bezmrežnim metodama gdje funkcija na domeni određuje numeričko rješenje danog problema polja. Razmotrit će se bezmrežne metode temeljene na &#39;&#39;oblaku&#39;&#39; čvorova koje su značajno manje osjetljive na promjene u konfiguraciji materijala.]]></summary_hr><summary_en><![CDATA[The project focuses on developing numerically efficient and dynamically adaptive parametric representations of shape which autonomously provide increased modeling capacity for the 3D shape itself and for the shape functions in numerical methods. The initial shape iteration will start from 3D point clouds, possibly resulting from shape digitization (existing high-resolution optical scanning system). Mathematical parameterization of the point clouds will be based on parametric surfaces. Integral as well as chained piecewise surfaces will be explored and compared. Dynamic aspects of the parameterizations will be studied. The shape and possibly topology of the object will be changing in simulation/ optimization quasi-time iterations. During the process, edges and peaks may disappear and new ones may arise, whereby the parameterization must be autonomously adaptable to such changes.Strategies for controlled reductions of the parameterization data-sets based on permissible threshold values for peak error and cumulative error norms will also be studied. These strategies will include adaptive re-allocation of the control points using feature recognition procedures (edges, peaks) based on eigenvalue ratios and slope and curvature estimators. Adaptive partitioning of the overall object surface based on different criteria will be evaluated.The optimization process involves extensive field calculations i.e. solving field problems governed by partial differential equations. The above shape modeling aspects also apply with meshless methods where a function across the domain determines the numerical solution of a given field problem. The option applied here will be meshless methods which are based on a nodes “cloud” and are dramatically less sensitive to the change in a material configuration.]]></summary_en></project><project>
<id>3745</id><title_hr><![CDATA[Razvoj numeričkih modela armirano-betonskih i kamenih zidanih konstrukcija izloženih potresnom opterećenju zasnovanih na diskretnim pukotinama]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5683</user_id><user_firstLast_name>Željana Nikolić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-5825</code><acronim><![CDATA[SeismoNuMod]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Građevinarstvo, </scie_field_hr><scie_field_en>Civil engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu Fakultet građevinarstva, arhitekture i geodezije]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Civil Engineering, Architecture and Geodesy]]></institution_en><team_members_id>25469</team_members_id><team_members_names><![CDATA[ Doktorand: Jadran Čarija ]]></team_members_names><keywords_hr><![CDATA[Numeričko modeliranje,  Potresno djelovanje, AB konstrukcije, Kamene zidane konstrukcije, Diskretne pukotine]]></keywords_hr><keywords_en><![CDATA[Numerical modelling, Earthquake loading, RC structures, Stone masonry structures, Discrete cracks]]></keywords_en><summary_hr><![CDATA[Pojava pukotina je jedan od dominantnih uzroka nelinearnosti u krtim i kvazi-konstrukcijama koja dovodi do pojave lokaliziranog sloma i predstavlja ozbiljan izazov u numeričkom modeliranju. Proces nastanka pukotina započinje na mikrorazini, a progresivnim srastanjem stvaraju se makropukotine koje predstavljaju diskontinuitet u materijalu. Precizno modeliranje otvaranja i zatvaranja pukotina jedan je od ključnih čimbenika koji utječe na pouzdanost modela za analizu konstrukcija, posebno onih izloženih potresnom opterećenju. Sofisticirani numerički modeli temeljeni na metodi odgovora u vremenu i inkrementalnoj dinamičkoj analizi imaju značajnu ulogu u simulaciji ponašanja takvih konstrukcija prije i poslije sloma. U ovom projektu planira se razvoj dvaju nelinearnih modela za inkrementalnu dinamičku analizu konstrukcija zasnovanih na diskretnim pukotinama s različitim pristupima u rješavanju ovog problema. Jedan će biti novi 3D model za potresno opterećene armirano-betonske i kamene zidane konstrukcije ojačane trnovima i klamfama, zasnovan na metodi kombiniranih konačno-diskretnih elemenata kod koje pukotine nastaju u kontaktnim elementima smještenima duž rubova konačnih elemenata. Model će omogućiti raspucavanje, dinamičku interakciju razdvojenih elementa i praćenje ponašanja konstrukcije prije i nakon sloma. Drugi model će biti zasnovan na metodi konačnih elementa s ugrađenim diskontinuitetom i ugrađenom armaturom koja omogućuje nastanak pukotina neovisno o mreži konačnih elemenata i primijenit će se na armirano-betonske konstrukcije. Validacija razvijenih modela će se provesti usporedbom s dostupnim rezultatima eksperimentalnih istraživanja, dok se u svrhu validacije modela za kamene zidane konstrukcije planiraju provesti vlastiti eksperimenti na potresnoj platformi. Na kraju će se provesti usporedne analize ponašanja konstrukcija s oba modela.]]></summary_hr><summary_en><![CDATA[Crack opening is one of the dominant causes of nonlinearity in brittle and quasi-brittle structures which leads to localized failure and stands out as a serious challenge in numerical modelling. The process of crack initiation starts at a micro-scale, and with progressive growth, micro-cracks coalesce into macro-cracks representing discontinuities in the material. Therefore, a realistic modelling of crack initiation and propagation is one of the key factors that affect the reliability of the model for analysing the structures, especially those subjected to earthquakes. Sophisticated numerical models based on time dependent and incremental dynamic analysis can play an important role in simulating the behaviour of such structures before and after collapse. This project aims to develop two nonlinear numerical models for incremental dynamic analysis of structures based on the model of discrete cracks. The first one will be a novel 3D model for reinforced concrete and stone masonry structures strengthened with clamps and bolts based on the combined finite discrete element method where the cracks are modelled through the contact elements implemented between finite elements. The model enables crack initiation and propagation, dynamic interaction of separate elements and monitoring of structural behaviour before and after the collapse. The second model will be based on the finite element method with embedded discontinuity and embedded reinforcement, which allows for crack initiation and propagation independent of finite element mesh and will be applied to reinforced concrete structures. The novel numerical models for reinforced concrete structures will be validated by available experimental research, while our own experiments are planned to be performed at shaking table for the validation of stone masonry structure model. Thereafter, the comparative analysis of the behaviour of real structures with both models will be conducted.]]></summary_en></project><project>
<id>3746</id><title_hr><![CDATA[(PHOENIX) People for tHe eurOpean bio-ENery mIX]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5040</user_id><user_firstLast_name>Milan Vujanović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-4216</code><acronim><![CDATA[]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, </scie_field_hr><scie_field_en>Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>22608</team_members_id><team_members_names><![CDATA[ Doktorand: Tibor Bešenić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>3747</id><title_hr><![CDATA[Zelena  otapala  za  zelene  tehnologije]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3228</user_id><user_firstLast_name>Ivana Radojčić Redovniković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-3478</code><acronim><![CDATA[GREEN]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Biotehnologija, </scie_field_hr><scie_field_en>Biotechnology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Food Technology and Biotechnology]]></institution_en><team_members_id>21346</team_members_id><team_members_names><![CDATA[ Doktorand: Manuela  Panić ]]></team_members_names><keywords_hr><![CDATA[biokataliza, biološkiaktivni spojevi, eutektična  otapala, ionske kapljevine, pročišćavanje tekućih goriva]]></keywords_hr><keywords_en><![CDATA[biocatalysis, biologically active compounds, deep euectic solvents, fuel purification, ionic liquids]]></keywords_en><summary_hr><![CDATA[Posljednjih su nekoliko godina globalna ekonomska kriza,rastuće cijene hrane, energije i drugih roba te povećana svijesto utjecaju čovjeka na okoliš potaknuli koncept zelene ekonomijeu središte političkih, gospodarskih i znanstvenih rasprava. Uskladu s time ionske kapljevine i eutektična otapala intenzivnose istražuju s ekološkog, tehnološkog i ekonomskog gledištakao zamjena za tradicionalna organska otapala. Ciljpredloženog Projekta jest stjecanje znanja o prirodnim ionskimkapljevinama i eutektičnim otapalima dizajniranih za specifičneprocese u prehrambenoj tehnologiji, biotehnologiji i kemijskojtehnologiji. U sklopu Projekta pripravit će se ionske kapljevine ieutektična otapala iz prirodnih sirovina poput kolinijevih soli,ugljikohidrata, organskih kiselina i aminokiselina, odreditinjihova fizikalno-kemijska svojstva i toksičnost te primjeniti kaootapala u ekstrakciji biološki aktivnih spojeva iz nusproizvodaprehrambene industrije, biokatalitičkim reakcijama te procesupročišćavanja tekućih goriva. Prema našim saznanjima uRepublici Hrvatskoj jedina smo istraživačka grupa koja sesustavno bavi izučavanjem zelenih otapala, a što je u skladu sključnim ciljevima EU vezanim uz očuvanje okoliša. S tim u svezi,financiranje ovog projekta iznimno je važno za nastavak našegmultidisciplinarnog istraživanja zelenih otapala (priprava,karakterizacija i primjena) što je također od velikog interesa i zahrvatsku akademsku zajednicu. Provedbom predloženogProjekta profilirat ćemo se u vodeću grupu u područjuistraživanja prirodnih ionskih kapljevina i eutektičnih otapala, nesamo u RH već i u inozemstvu. Također, stečeno znanje moćićemo prenijeti zainteresiranim industrijskim parterima kako biimplementirali zelena otapala u postojeće i/ili nove procese.]]></summary_hr><summary_en><![CDATA[Global economic crisis, soaring commodity prices and growingawareness of humanity&#39;s impact on the environment havepushed the “green economy” concept into mainstream policydebate in recent years. Accordingly, as a promising alternativeto traditional organic solvents from both the environmental andtechnological perspectives, neoteric solvents (neoteric = new,recent, modern), ionic liquids (ILs) and deep eutectic solvents(DESs), have been dramatically expanding in popularity as anew generation of designer solvents with possible applicationsin various industrial fields. The aim of proposed Project is to gainan in-depth understanding of the natural ILs and DESs withfine-tuned properties, as well as to implement these solventsinto food technology, biotechnology and chemical technology. Within the Project ILs and DESs, based on renewable sourcessuch as cholinium salts, sugars, organic acids and amino acids,will be prepared and characterized, followed by examination oftheir applicability as solvents for extraction of phenoliccompounds from wine and oil by-product, in biocatalyticreactions and in fuel purification process. To our knowledge, inthe Republic of Croatia we are the only research group involvedin multidisciplinary and systematic approach in the investigationof ILs and DESs. Thus, proposed Project would enable ourfurther research in the field of preparation, characterization andapplication of these new green solvents, which is of greatimportance for Croatian academic community in order tosuccessfully follow the EU directives. Additionally, knowledgegained through proposed Project will profile us as the leadinggroup in the field of natural ILs and DESs research, both in theRepublic of Croatia and EU, for fostering knowledge transfer toacademia and potential industry partners. ]]></summary_en></project><project>
<id>3748</id><title_hr><![CDATA[Cerebrovaskularna regulacija tijekom apneje kod elitnih ronilaca na dah]]></title_hr><title_en><![CDATA[]]></title_en><user_id>7688</user_id><user_firstLast_name>Zeljko Dujic</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-3719</code><acronim><![CDATA[CEREBROFLOW]]></acronim><duration>05.10.2016 - 26.06.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Split School of Medicine]]></institution_en><team_members_id>22679</team_members_id><team_members_names><![CDATA[ Doktorand: Tanja Mijačika ]]></team_members_names><keywords_hr><![CDATA[Moždani protok krvi, moždani metabolizam, hipoksija, hiperoksija, hiperkapnija, hipokapnija]]></keywords_hr><keywords_en><![CDATA[Cerebral blood flow, cerebral metabolism, hypoxia, hyperoxia, hypercapnia, hypocapnia]]></keywords_en><summary_hr><![CDATA[Glavni cilj ovog prijedloga je da se sprovedu serije sve složenijih studija kojima bi se istražila nova fiziološka pitanja u sklopu fiziologije apneje, s posebnim naglaskom na fiziologiju mozga, te integraciju s cirkulacijskim i respiracijskim refleksima. Postavljanjem  novih znanstvenih pitanja u ovom prijedlogu želimo obogatiti i nadograditi naše razumijevanje temeljnih mehanizama moždanog protoka krvi u uvjetima teške hipoksije. Raščlanjivanje prirode odnosa između kisika, cerebralne perfuzije, moždanog metabolizma, te njihove važnosti za moždanu homeostazu je ključan korak prema razumijevanju fiziologije mozga u odnosu na ostale tjelesne sustave. Zadržavanje daha uzrokuje izniman stres za kardiovaskularni sustav i mozak, usprkos kojem elitni ronioci na dah uspijevaju tolerirati značajan pad kisika koji samo u ponekim slučajevima rezultira gubitkom svijesti (sinkopa). Mehanizmi odgovorni za adaptaciju ekstremnoj hipoksiji nam mogu poslužiti kao koristan model za istraživanje cerebrovaskularne regulacije tijekom prijetnje fiziološkoj homeostazi, kao što je to slučaj kod bolesti ili traume, tim više što je samo znanstveno istraživanje regionalne moždane perfuzije tijekom kardiorespiracijskih izazova, tjelesne aktivnosti i patoloških stanja tek u svojim začecima. Prema tomu, istraživanje regionalne cerebrovaskularne regulacije, te njene povezanosti s cirkulacijskim i respiracijskim sustavom kod zdravih, treniranih ronioca na dah će rezultirati novim uvidom u cerebrovaskularnu funkciju, kao i uvidom u integraciju ostalih sustava kod ljudi. Štoviše, rasvjetljavanje ovakvih mehanizama je od izuzetno velikog značaja za razumijevanje mnogobrojnih patoloških stanja vezanih uz arterijsku hipoksemiju i/ili promjene u viskoznosti krvi ili koncentraciji hemoglobina. ]]></summary_hr><summary_en><![CDATA[The main objective of this proposal is to propose and conduct a series of incrementally progressive studies to examine new physiological questions in apnea diving physiology, with particular focus on brain physiology and the related integration with circulatory and respiratory reflexes. Addressing the novel questions outlined in this proposal will enrich our understanding of the fundamental mechanisms governing cerebral blood flow in conditions of severe hypoxia. Characterization of these relationships between oxygen, cerebral perfusion and cerebral metabolism, and their respective importance on brain homeostasis is a fundamental step toward raising our understanding of brain physiology to that of other body systems. Breath holding exerts a potent stress to the cardiovascular system and brain, yet elite breath-hold divers are able to tolerate marked reductions in blood oxygenation that only sometimes results in loss of consciousness (syncope). The mechanisms allowing such tolerance to hypoxemic extremes may serve as a useful model for the study of cerebrovascular regulation during physiological duress often observed in trauma and disease. This is especially true given that the study of regional brain perfusion during cardiorespiratory challenges, exercise, and in pathology has only begun in the past several years. Thus, the study of regional cerebrovascular regulation and its relation to the circulatory and ventilatory in healthy, trained breath-hold divers will yield new insight into the cerebrovascular function and systems integration in humans. Moreover, elucidation of these mechanistic relationships is paramount to our comprehension of myriad pathologies associated with arterial hypoxemia and/or elevations in blood viscosity or hemoglobin levels.]]></summary_en></project><project>
<id>3749</id><title_hr><![CDATA[Održivost ekonomske politike i razvoja u Hrvatskoj]]></title_hr><title_en><![CDATA[]]></title_en><user_id>503</user_id><user_firstLast_name>Jurica Šimurina</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-6138</code><acronim><![CDATA[SCrEPoDe]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, </scie_field_hr><scie_field_en>Economy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Ekonomski fakultet u Zagrebu]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Economics and Business]]></institution_en><team_members_id>22694</team_members_id><team_members_names><![CDATA[ Doktorand: Nora Mustać ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[sustainability, economic structure, resources, public sector economics, spatial economics]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[RESEARCH QUESTION: Do Croatian economic policies lead to sustainability with respect to scarce resources, demographic changes, spatial effects and economic structure?Long term Croatian economic policy and development stem from both short term policies and long term sustainability. By combining macroeconomic and development policies, the long term objectives of sustainability of natural resources, public sector economics, demographic changes, spatial economics and overall economic structure may be achieved. Thus, the goals of this research stem from the above stand point, and include:•	Establish development policies for Croatia based on sustainable use of natural resources•	Show how change of age structure in Croatia affects fiscal sustainability and short and long run economic development•	Explore how three way interaction among increasing returns, transportation costs, and movement of factors of production affect international, regional and urban development•	Analyze structure of Croatian economy suitable for sustainable and deeper integration into the EU•	Define integrative policies which lead to sustainable development of Croatian economyFor achieving above mentioned goals, the project team is separated into four equally contributing groups and is structured as follows:1. Sustainability of economic development within the context of scarce natural resources.2. Sustainability of public sector economics and the labor market in the context of demographic changes in Croatia.3. Sustainability of the degree of centralization in the context of spatial (international, urban and regional) economics.4. Sustainability of current economic structure within the context of the EU integrationOutcomes of the research will be innovative approach to controversy of long vs. short term development and stability, as well as integrative approach to different, and thus far, insufficiently interconnected fields of economic research.]]></summary_en></project><project>
<id>3750</id><title_hr><![CDATA[Implicitna ličnost i radno ponašanje]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3974</user_id><user_firstLast_name>Zvonimir Galic</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-7149</code><acronim><![CDATA[IPAWB]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Psihologija, </scie_field_hr><scie_field_en>Psychology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>22773</team_members_id><team_members_names><![CDATA[ Doktorand: Mitja Ružojčić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[implicit personality, work behavior, conditional reasoning, aggressiveness, power motive.]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Recent developments in implicit personality conceptualization and measurement could shed a new light on the relationship between personality and work behavior and help us explain, predict, and even control important aspects of work behavior. In the focus of this project are conditional reasoning measures of implicit personality that represent “a model for psychometric, conceptual, and theory based implicit association measurement” (Landy, 2008, p. 390). This measurement system is called conditional reasoning because it is based on the assumption that an individual’s reasoning is conditional on his/her personality and that these differences in reasoning can be measured with inductive reasoning tasks capturing unconscious cognitive biases that stem from individuals’ personality motives.The project aims to further advance the knowledge about the conditional reasoning method of personality measurement, and the relationship between (implicit) personality and work behavior by exploring implicit aggression and power motive. We plan to (1) test the implicit nature of conditional reasoning tests and the strength of their relationship with other implicit personality measures intended to assess similar constructs; (2) further explore the relationship between the conditional reasoning tests and work behavior by testing mediators and moderators of that relationship; (3) study how different measures of implicit and explicit personality assessing the same construct (i.e., aggressiveness and power motive) interact in explaining work behaviors. We plan to focus on aggressiveness and power motive because they have the pivotal role in explaining very important aspects of work behavior such as counterproductive work behavior and leadership.]]></summary_en></project><project>
<id>3751</id><title_hr><![CDATA[Općeslavenski lingvistički atlas (OLA) i Europski lingvistički atlas (ALE) ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>18899</user_id><user_firstLast_name>Ranko Matasović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-8194</code><acronim><![CDATA[]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Kroatologija, </scie_field_hr><scie_field_en>Croatology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>29174</team_members_id><team_members_names><![CDATA[ Doktorand: Pavao Krmpotić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>3755</id><title_hr><![CDATA[Centromerna genomika beskralješnjaka]]></title_hr><title_en><![CDATA[]]></title_en><user_id>332</user_id><user_firstLast_name>Brankica Mravinac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-6666</code><acronim><![CDATA[CENGEN]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>21386</team_members_id><team_members_names><![CDATA[ Doktorand: Tena Gržan ]]></team_members_names><keywords_hr><![CDATA[centromera, CenH3, satelitna DNA, ponovljena DNA, evolucija, kornjaši, oblići, školjkaši]]></keywords_hr><keywords_en><![CDATA[centromere, CenH3, satellite DNA, repetitive DNA, evolution, beetles, nematodes, molluscs]]></keywords_en><summary_hr><![CDATA[Centromera je domena esencijalna za razdvajanje kromosoma u staničnim diobama. Razumijevanje centromerne strukture i funkcije od velikog je značaja u biologiji, a značajno je i s biomedicinskog stajališta. Funkcionalne centromere obilježene su centromerno specifičnim proteinom sličnim histonu H3 (CenH3). Centromerni identitet određuju i genomski i epigenetički mehanizmi, koji podstiču brzu koevoluciju i vrsnu specifičnost proteina CenH3 i njemu pridruženih sekvenci DNA bez narušavanja centromerne funkcije. Složenost i varijabilnost centromernog područja uzrok su još uvijek fragmentalne percepcije centromerne genomike, koja je razrađena samo na nekoliko biljnih i životinjskih modelnih organizama. Sekvencirani genomi modelnih organizama beskralješnjacima s različitom konstitucijom centromernih regija nedavno su postali dostupni. Kornjaši roda Tribolium imaju centromere uklopljene duboko u pericentromerni heterokromatin bogat satelitnim DNA, oblići korijenovih kvržica roda Meloidogyne imaju holocentrične kromosome, dok školjkaš Crassostrea gigas ima nejednoliku razdiobu satelitnih DNA u centromerama. Glavni cilj ovog projektnog prijedloga je identificirati CenH3 i njima pridružene sekvence DNA, kao i njihove nefunkcionalne varijante kako bi se istražila genomika različito organiziranih centromera. Nadalje, biti će ispitani organizacijski i evolucijski obrasci proteina CenH3 i centromernih sekvenci DNA. Strategija istraživanja kombinira identifikaciju CenH3, kromatinsku imunoprecipitaciju (ChIP) s antitijelima na CenH3, fluorescencijsku hibridizaciju in situ (FISH), imunofuorescencijsku lokalizaciju in situ (IF) i bioinformatičke metode. Takav integrativni pristup će ponuditi informacije o ovim funkcionalno značajnim dijelovima koji najčešće nedostaju u sekvenciranim genomima i unaprijediti naše razumijevanje sinergije i koevolucije centromernih sekvenci DNA i proteinskih komponenata. ]]></summary_hr><summary_en><![CDATA[The centromere is a domain essential for chromosomal segregation in cell divisions. Understanding its structure and function is of the highest importance in biology, and also crucial from biomedical point of view. Functional centromeres are marked by centromere-specific histone H3-like proteins (CenH3). Centromere identity involves both genomic and epigenetic mechanisms, favoring rapid co-evolution and species specificity of CenH3 and associated DNA sequences without impairing the function. Complexity and variations make perception of centromere genomics still fragmental and worked out only in a few most common plant and animal model systems. Among invertebrates, sequenced genomes of model organisms with diverse constitution of centromeric regions became recently available. Tribolium beetles have centromeres embedded deeply into the satellite DNA-rich pericentromeric heterochromatin, Meloidogyne root-knot nematodes have holocentric chromosomes, while the mollusk Crassostrea gigas lacks uniform distribution of satellite DNAs in centromeres. The main goal of this research proposal is to identify CenH3 and CenH3-associated DNA sequences as well as their non-functional genomic counterparts in order to explore genomics of differently organized centromeres. In addition, organizational and evolutional aspects of CenH3 and centromeric DNA sequences will be addressed. The research strategy will combine CenH3 identification, chromatin immunoprecipitation (ChIP)-based assays using anti-CenH3 antibodies, fluorescence in situ hybridization (FISH), immunofluorescence in situ localization (IF) and the bioinformatics pipeline. Such integrative approach will help filling the gaps in functionally essential regions of sequenced genomes and will forward our understanding of the synergy and coevolution between DNA sequences and protein components in the centromeres.  ]]></summary_en></project><project>
<id>3757</id><title_hr><![CDATA[ERC StG 337283 MembranesAct]]></title_hr><title_en><![CDATA[]]></title_en><user_id>2682</user_id><user_firstLast_name>Ana-Sunčana Smith</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-9140</code><acronim><![CDATA[]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>6627</team_members_id><team_members_names><![CDATA[ Doktorand: Nataša  Vučemilović-Alagić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>3758</id><title_hr><![CDATA[Razvoj biokompatibilnih materijala na temelju hidroksiapatita za primjene u inženjerstvu koštanog tkiva ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>13014</user_id><user_firstLast_name>Marica  Ivanković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-4272</code><acronim><![CDATA[HATEA]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Kemijsko inženjerstvo, </scie_field_hr><scie_field_en>Chemical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet kemijskog inženjerstva i tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Chemical Engineering and Technology]]></institution_en><team_members_id>22646</team_members_id><team_members_names><![CDATA[ Doktorand: Leonard Bauer ]]></team_members_names><keywords_hr><![CDATA[inženjerstvo koštanog tkiva, skelet, hidroksiapatit, biorazgradivi polimeri, in vitro/vivo ponašanje]]></keywords_hr><keywords_en><![CDATA[bone tissue engineering, scaffold, hydroxyapatite, biodegradable polymers, in vitro/vivo behaviour]]></keywords_en><summary_hr><![CDATA[Izazov za inženjerstvo koštanog tkiva je razvoj odgovarajućih skeleta (engl. scaffold) koji omogućavaju dobru integraciju s okolnim tkivom. Posljednjih godina intenzivno se istražuje hidroksiapatit (HAp) zbog njegove kemijske i strukturne sličnosti s anorganskom matricom prirodne kosti i odlične bioaktivnosti. Nedostatak HAp-a su njegova slaba mehanička svojstva pa se obično kombinira s polimerima i metalima. U prethodnim istraživanjima pripravili smo visoko porozne skelete na temelju HAp-a i poli(?-kaprolakton)-a (PCL) korištenjem jednostavnih i ekonomičnih postupaka. In vitro istraživanja sa stanicama MC3T3-E1 pokazala su da skeleti nisu toksični i da su odgovarajuća 3D podloga za prianjanje, umnažanje i diferenciranje stanica. Provedene su i preliminarne sinteze poroznih skeleta na temelju HAp-a i kitozana. Dobiveni su vrlo obećavajući rezultati uzimajući u obzir poroznost i međusobnu povezanost pora te netoksičnost materijala.Opći cilj ovog projekta je poboljšanje mehaničkih i bioloških svojstava biokompatibilnih materijala na temelju hidroksiaptita, posebice njihove sposobnosti poticanja aktivnog stvaranja kosti. Specifični ciljevi projekta su:  (1) sustavno istražiti utjecaj vrste i količine iona elemenata u tragovima (Mn, Si, Zn, Cu..) na biološko ponašanje skeleta;  (2) istražiti ponašanje skeleta in vivo, implantiranjem odabranih skeleta u oštećenja potkoljenične kosti kunića; (3) istražiti mogućnosti kanalnog kutnog prešanja za dobivanje novih HAp/titan kompozita za primjene u inženjerstvu koštanog tkiva.  Čvrsto vjerujemo da će projekt doprinijeti boljem razumijevanju sinteze, strukture i svojstava novih materijala za primjene u inženjerstvu koštanog tkiva. Razvoj novih skeleta na temelju HAp-a može imati pozitivne implikacije za društvo u smislu tretiranja i liječenja koštanih oštećenja te tako poboljšati kvalitetu života pacijenata, posebice starijih. Nadalje, ova istraživanja mogu otvoriti vrata novim primjenama skeleta u istraživanju matičnih stanica. ]]></summary_hr><summary_en><![CDATA[The challenge of bone tissue engineering (BTE) is to develop bone scaffolds that allow a good integration with the surrounding tissues. Particular systems of interest are scaffolds based on hydroxyapatite (HAp), due to its chemical and structural similarity to the inorganic matrix of natural bone and excellent bioactivity. To overcome disadvantages such as poor mechanical properties of HAp it has been combined with polymers and metals. In our previous studies highly porous HAp and poly(?-caprolactone),(PCL),- coated HAp scaffolds were prepared using simple and inexpensive methods. In vitro cell culture studies showed that scaffolds are nontoxic and provide an adequate 3D support for the attachment, proliferation and differentiation of MC3T3-E1 cells. Some preliminary studies on preparation of HAp/chitosan scaffolds showed promising results regarding porosity and interconnectivity of pores and nontoxicity.The overall objective of this project is to investigate methods to improve mechanical and biological properties of HAp-based materials especially the ability to propagate active bone formation. The specific objectives of the project are: (1) to investigate systematically the effect of dopants (Mn, Si, Zn, Cu..) on biological performance of the scaffolds (2) to assess in vivo biological performance of scaffolds by implanting the selected scaffolds in rabbits&#39; lower legs defects. (3) to investigate the potential of equal-channel angular pressing to produce novel HAp/titanium composites for BTE applications.We strongly beleive that the research will contribute to the better understanding of the synthesis, structure and properties of scaffolds for BTE applications. Development of novel HAp-based scaffolds could have positive implications for society in terms of treating and healing bone defects, improving quality of life for trauma patients and the elderly. Additionally, the research will open the door to new applications of scaffolds in stem cells research.]]></summary_en></project><project>
<id>3759</id><title_hr><![CDATA[Kompetencijski profil akademske profesije: između novih zahtjeva i mogućnosti]]></title_hr><title_en><![CDATA[]]></title_en><user_id>380</user_id><user_firstLast_name>Jasminka Ledić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-2376</code><acronim><![CDATA[APROFRAME]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Pedagogija, </scie_field_hr><scie_field_en>Pedagogy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Filozofski fakultet u Rijeci]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>22747</team_members_id><team_members_names><![CDATA[ Doktorand: Ivana Miočić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[higher education, academic profession, competence framework, academic roles, higher education policy]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Changes in social environment indicate the need for a redefinition of the academic profession’ traditional role and for its more comprehensive understanding, which leads to the requirements for the development of new competences. Research results indicate the increased scope of workload and demands for new approaches to teaching, disharmony between teaching and research, increasing administrative duties, and the insistence on a stronger connection between the academic community and social environment.This project aims to determine how academics in Croatia assess the relevance of various competences, and how they assess, perceive and interpret possession of various competences that shape contemporary academic profession. It is expected that the research results in a proposal of the academic profession’ competence framework.In the research quantitative and qualitative methodological approach (survey and semi-structured interview) will be used. The survey consists of the competence framework elements which are to be evaluated by the participants in terms of the assessment of their (1) relevance and (2) possession. The interviews will explore the deeper perception of academics and challenging issues within the framework, and gain a ‘holistic’ (comprehensive, systemic, integrated) understanding of context, while capturing data on the participants perceptions ‘from the inside’.The final definition of an integrated competence framework which includes different dimensions of the academic profession is an original research contribution. Bearing in mind that the research of the academic profession is neglected in the national research discourse, the results of this study will also be a starting point for defining recommendations for (national) educational policies. This will particularly apply to profiling the academic profession in the context of recent strategic directions in Croatia, in accordance with the requirements of the international scientific community.]]></summary_en></project><project>
<id>3760</id><title_hr><![CDATA[Uspostavljanje međukulturnih poveznica kroz prijevode dječje književnosti: tekst, kontekst, strategije]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4856</user_id><user_firstLast_name>Smiljana Narančić Kovač </user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-7206</code><acronim><![CDATA[BIBRICH]]></acronim><duration>20.10.2016 - 09.01.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filologija, </scie_field_hr><scie_field_en>Philology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Učiteljski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Teacher Education]]></institution_en><team_members_id>5328</team_members_id><team_members_names><![CDATA[ Doktorand: Corinna Jerkin ]]></team_members_names><keywords_hr><![CDATA[hrvatska dječja književnost, prijevodne strategije, pripovjedna proza, 20. stoljeće, međukulturni prijenos, kanon, diskurs, ukriženi tekst]]></keywords_hr><keywords_en><![CDATA[Croatian children&#39;s literature, translation strategies, narrative fiction, 20th century, intercultural transfer, canon, discourse, crossover text]]></keywords_en><summary_hr><![CDATA[Cilj je predloženoga projekta prikazati i objasniti ulogu i status prevedenih djela u korpusu hrvatske dječje književnosti, opisati trendove i tendencije u povijesnoj perspektivi te otkriti i protumačiti upotrijebljene prijevodne strategije. Projekt je usmjeren na prijevode pripovjedne proze na hrvatski i iz hrvatskoga na druge jezike tijekom dvadesetoga stoljeća.Međunarodna istraživanja dječje književnosti u novije se vrijeme u znatnoj mjeri okreću k poredbenoj dječjoj književnosti, fokusirajući se na analizu prijevoda, međukulturni prijenos i kontakte među jezicima i kulturama. U tome se podudaraju s prijevodnim studijima u širem smislu. Nakana je uspostaviti skupinu istraživača koja bi razvila takvo područje istraživanja u hrvatskome kontekstu, i koja će postaviti istraživačke standarde i prilagoditi primjerenu metodologiju specifičnostima opisanoga predmeta istraživanja.U planu je sastavljanje bibliografije prijevoda dječjih knjiga i ukriženih tekstova (crossover texts), tj. djela ujedno namijenjenih dječjem i odraslom čitateljstvu. Podatci će se analizirati i tumačiti s obzirom na polazišne i posredne jezike pojedinih prijevoda, povijesne trendove, izbor knjiga u odnosu na kanon dječje književnosti, nakladničke prakse i druge aspekte. Nadalje, odabrani primjeri prijevoda analizirat će se kako bi se utvrdile prijevodne strategije na različitim razinama diskursa. Razmotriti će se jezični, pripovjedni, kulturni i međukulturni aspekti s ciljem otkrivanja prijevodnih normi i strategija odomaćivanja (domestikacije). Hrvatskim će se djelima prevedenima na druge jezike posvetiti posebna pozornost.Rezultati će se analizirati i interpretirati kako bi se objasnile prijevodne tendencije, trendovi i dinamika književnih suodnosa tijekom dvadesetoga stoljeća iz hrvatske perspektive, kao i u međunarodnome kontekstu.Predloženi će projekt pripremiti temelj za dalji razvoj opisanoga područja istraživanja i za buduću širu međunarodnu suradnju.   ]]></summary_hr><summary_en><![CDATA[The proposed project aims to depict and explain the role and status of translated books within Croatian children’s literature, to describe trends and tendencies in a historical perspective, and to establish and interpret adopted translation strategies. The project focuses on translations of narrative fiction into and from Croatian over a span of a hundred years, i.e. in the 20th century. International scholarship in the field of children’s literature has recently turned towards comparative children’s literature, focusing on translation, intercultural transfer and contacts among languages and cultures. In so doing, it intersects with recent trends in translation studies in general. The proposed project aims to establish a team of researchers who would develop such an area of research in Croatia. The goal is to set research standards and fine-tune appropriate methodology.The researchers intend to assemble a bibliography of translated children’s books and crossover texts. Records will be analysed and interpreted with respect to the source and intermediary languages represented, historical trends, book selection relative to the canon of children’s literature, publishing practices and other aspects. Next, a selection of published books will be analysed for translation strategies at several levels of discourse. The researchers will address linguistic, narrative, cultural and intercultural aspects, and focus on uncovering translation norms and domestication strategies. Croatian books translated into other languages will receive special attention.Finally, the results will be analysed and interpreted to explain the documented translation flows, trends, and the dynamics of literary relationships in the 20th century, from the Croatian perspective and in the international context. The proposed project will present a sound foundation for further development of the established area of research and of a wider international cooperation in the future. ]]></summary_en></project><project>
<id>3765</id><title_hr><![CDATA[Utjecaj akvakulture na prirodne morske populacije]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4254</user_id><user_firstLast_name>Ivan  Katavić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-4913</code><acronim><![CDATA[AquaPop]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Biotehnologija, </scie_field_hr><scie_field_en>Biotechnology, </scie_field_en><institution_hr><![CDATA[Institut za oceanografiju i ribarstvo]]></institution_hr><institution_en><![CDATA[Institute of Oceanography and Fisheries]]></institution_en><team_members_id>18929</team_members_id><team_members_names><![CDATA[ Doktorand: Iva  Žužul ]]></team_members_names><keywords_hr><![CDATA[Akvakultura, utjecaj, prirodne populacije riba i školjkaša, ekološke zamke, prebjezi, genetske interakcije]]></keywords_hr><keywords_en><![CDATA[Aquaculture, Impact, Wild fish and shellfish populations, ecological traps, escapees, genetic interactions]]></keywords_en><summary_hr><![CDATA[Zbog stalnog rasta broja lokacija za uzgoj morskih organizama javlja se sveprisutna zabrinutost da marikultura kao gospodarska djelatnost može predstavljati opasnost za morsku biološku raznolikost kroz negativni utjecaj na prirodne populacije morskih organizama kao i cjelokupni morski ekosustav. Ekološke interakcije se odražavaju kroz činjenicu da kavezne uzgojne instalacije postaju nove ekološke niše za prirodne populacije ribe kod kojih promjene u fiziologiji i ponašanju su moguće. Drugi rizik za okoliš se očituje u mogućem utjecaju zbjegova uzgojne ribe iz kaveza prisutne u morskom okolišu kao rezultat slučajnog bijega iz kaveza ili namjernog poribljavanja. Pobjezi ili poribljavane jedinke iz uzgoja predstavljaju potencijalni rizik genetskoj osnovi izvornih ribljih populacija. Zbog boljeg razumijevanja složenosti  utjecaja akvakulture na prirodne populacije, ovaj projekt će iskoristiti najnovije instrumentalne i genetske pristupe s ciljem podržavanja uzgojnih i upravljačkih aktivnosti, kao i zaštite morskog okoliša. Projekt uključuje: (i) uporabu suvremenog sustava stereoskopske kamere i multivarijatnih analizi indirektnih pokazatelja kondicije s ciljem procjene uloge uzgajališta kao ekoloških zamki divljih ribljih populacija, (ii) korištenje forenzički svojstvenih genetskih alata u procjeni genetske strukture divljih/uzgojnih riba i školjkaša , (iii) uporaba suvremenog genetski-analitičkog pristupa s ciljem određivanja porijekla uzgojnih populacija i utvrđivanja možebitnih genetskih interakcija populacija iz uzgoja s prirodnim/divljim populacijama iste vrste, a na kraju (iv) procjena utjecaja translokacije mlađi kamenica između geografski udaljenih uzgojnih lokacija na genetsku strukturu izvornih populacija kamenice u hrvatskom dijelu Jadrana.Zaključno, predloženi projekt se nadovezuje na zajednički izazov evropske zajednice  koji se očituje u poticanju razvoja održive akvakulture kroz poboljšanje konkurentnosti i ekološki prihvatljive proizvodnje. Kako su potencijalno negativni učinci akvakulture prisutni u svim zemljama EU-a, međunarodna suradnja će se biti prepoznata i implementirana tijekom provedbe projektnih zadataka. Projektni ishodi će biti dostupni svim zainteresiranim strankama odnosno istraživačima, industriji, zakonodavnim tijelima i svim potencijalnim korisnicima.]]></summary_hr><summary_en><![CDATA[Expansion of marine farming sites raised the concern that aquaculture may pose a threat to biodiversity due to detrimental impacts on wild populations and ecosystem. Ecological interactions of farm installations are reflected through  acting as new ecological niches for the local fish where also altered wild fish physiology and behaviour may occur. Another environmental risk is the potential impact of releasing farmed fish into the wild, through accidental escape or deliberate restocking. Escapes or releases of the domesticated aquaculture fish pose a potential risk of adverse effects on native fish gene pools. To better understand the complexity of aquaculture impacts on the native populations, this project will take advantage of cutting edge instrumental and genetic approaches to support aquaculture activity and management, as well as the protection of marine environment. This includes: (i) using novel stereoscopic camera system and multivariable analysis of proxy measure of fitness to asses do farms function as ecological traps for wild fish, (ii) using forensically validated genetic tools to assess genetic structure of wild/farmed fish and shellfish, (iii) using cutting edge genetic analytical approach to trace the origin of farmed fish and to monitor genetic interactions between fish from aquaculture and their wild conspecifics, and finally (iv) validation of the impact of oyster spat translocation between geographically distinct farming locations on genetic structure of native oysters populations in the Croatian part of the Adriatic Sea. Thus, this project addresses the common European challenge to develop sustainable aquaculture through improved competitiveness and environmentally-friendly production. As the potential adverse effects of aquaculture affect all EU countries, international collaboration will be implemented. The outcome of the project will be available to the researchers, the industry, policy makers and the general public.]]></summary_en></project><project>
<id>3766</id><title_hr><![CDATA[Uloga upale u razvoju zloćudnog tumora mokraćnog mjehura]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5769</user_id><user_firstLast_name>Janoš  Terzić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-6343</code><acronim><![CDATA[iBC]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Split School of Medicine]]></institution_en><team_members_id>22603</team_members_id><team_members_names><![CDATA[ Doktorand: Blanka Roje ]]></team_members_names><keywords_hr><![CDATA[mokraćni mjehur, rak, upala, mikrobiom, STAT3, IL-6]]></keywords_hr><keywords_en><![CDATA[bladder, cancer, inflammation, microbiome, STAT3, IL-6]]></keywords_en><summary_hr><![CDATA[Oko 20% smrtnih slučajeva od zloćudnih tumora posljedica je kronične upale. Virusne i bakterijske infekcije, infestacije parazitima, autoimunost i iritirajuće kemikalije uzrokuju upalne promjene koje stimuliraju začetak zloćudnih tumora, njihov ras i metastaziranje. Drugi istraživači i mi smo pokazali da su ključne molekularne poveznice između kronične upale i zloćudnih tumora citokin IL-6 i transkripcijski čimbenik STAT3. Postaje sve očitije da i mikrobni sastav pojedinog tkiva ima važnu ulogu u razvoju kronične upale i zloćudnih tumora. Uloga upale u patogenezi zloćudnih tumora mokraćnog mjehura (TMM) slabo je proučena iako upala izazvana sa Schistosoma haematobium potiče razvoj TMM, dok se upala uzrokovana s BCG uspješno koristi za njegovo liječenje.Za pročavanje upale u razvoju TMM koristiti ćemo najmodernije mišje modele (tzv. knock-out miševe) koijma će tumori biti inicirati s BBN-om. Analizirati ćemo: (1) ulogu IL-6 i (2) ulogu STAT3 u razvoju TMM kao i (3) terapijski potencijal STAT3 inhibitora. Nadalje planiramo (4) proučavati važnosti mikrobioma u nastanku TMM koristeći mišji model te bolesti uz upotrebu antibiotika koji će promijeniti sastav mikrobioma. Proučavajući (5) mikrobiomski sastav urina osoba s TMM i zdravih jedinki pokušati ćemo povezati određene mikrobe s TMM. Projekt proučava temeljne odlike zloćudnih tumora mokraćnog mjehura pa ukoliko se pokaže da smanjivanje aktivnosti STAT3 usporava razvoj TMM naši rezultati mogu potaknuti stvaranje novih lijekova (inhibitora STAT3) za TMM. Rezultati proučavanja mikrobioma mogu dovesti do novih preventivinih mjera (razvoja cjepiva ili upotrebe antibiotika). Kako je TMM sedmi tumor po učestalosti predloženi projekt je od velikog medicinskog, socijalnog i ekonomskog značaja. Članovi projektnog tima su iskusni istraživači su kao ključni znanstvenici objavljivali otkrića u najboljim časopisima poput Cancer Cell i Nature Genetics, što jamči uspješnu realizaciju projekta. ]]></summary_hr><summary_en><![CDATA[Around 20% of cancer deaths are a consequence of chronic inflammation. Viral and bacterial infections, parasitic infestation, autoimmunity or chemical irritants cause inflammatory changes that stimulate cancer initiation, promotion and metastasis. We and others have shown that main molecular links between inflammation and cancer are cytokine IL-6 and its transcription factor STAT3. It is becoming obvious that microbiome composition of particular niche is important element of inflammation and cancer development. The role of inflammation in urinary bladder cancer (BC) pathogenesis is poorly understood although chronic inflammation caused by Schistosoma haematobioum has pro-tumorigenic effect while acute inflammation caused by BCG is successfully used as a therapy for BC. To investigate the role of inflammation in BC development we will use BBN induced BC mice models and will study: (1) the role of IL-6 (by using IL-6 KO mice); (2) the role of STAT3 by assessing its targeted deletion in mice urothelium and (3) therapeutic potential of STAT3 inhibitor. Additionally, we plan to (4) test importance of microbiome in BC development by using mice BC model and antibiotic treatment to manipulate bladder microbiome composition and to (5) analyze human bladder cancer microbiome, in order to associate BC with specific microbiota.This project addresses fundamental questions of bladder cancerogensis. If altering STAT3 activity has inhibitory effect on BC development that finding can lead to new therapies (use of STAT3 inhibitors) for established BC. Findings generated by the microbiome analysis can lead to novel preventive measures (microbiota manipulation by antibiotics or vaccination). Team members are experienced scientist with publications in Cancer Cell and Nature Genetics which is securing successful realization of the project. Because BC is the seventh most common malignancy, proposed project is of great medical, social and economic importance.]]></summary_en></project><project>
<id>3768</id><title_hr><![CDATA[Europska bioetika na djelu]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5129</user_id><user_firstLast_name>Iva Rinčić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-3822</code><acronim><![CDATA[EuroBioAct]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filozofija, </scie_field_hr><scie_field_en>Philosophy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Medicine]]></institution_en><team_members_id>21391</team_members_id><team_members_names><![CDATA[ Doktorand: Maja Miloš ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Europe, integrative bioethics, Fritz Jahr, ecology, environment, Northern Adriatic]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The „European Bioethics in Action (EuroBioAct)” project primarily aims at:	1. completing theoretical basis for the „new European bioethics“ (by rounding-up 	research on Fritz Jahr, Ignaz Bregenzer, and other thinkers and conceiving a 	common platform with integrated ideas of modern environment science and 	ethics) and	2. applying that theoretical basis in practice (by compiling a list of „bioethical 	standards“ for settlements, containing concrete general and specific norms for 	preservation and improvement of local eco-systems – i.e., human health, animal 	and plant welfare, etc.).In the first phase of the project realisation, the participants would continue with the broadening and deepening of the theoretical basis of the „new European bioethics“ primarily by completing the research of the life and work of Fritz Jahr and his most important models (Ignaz Bregenzer and others). In the second phase of the project, three focused workshops would be organised determining the status of the general and special ecological needs for the three local communities (Plomin, Bakar, and Mali Lošinj) from the Northern Adriatic region. The three communities selected to host the workshops have either been recently experiencing ecological threats (Plomin – thermo-electric power plant; Bakar – cokery), or represent a highly-valuable and vulnerable natural insular pocket (Mali Lošinj – health tourism, dolphin wildlife refuge, fragrant gardens programme, etc.). Based on the theoretical background and the insights provided by the workshops, in the third phase of the project, created would be the „bioethical standards“, that is, a set of principles and measures of the correct relation of men toward their own health, animals, plants, and the eco-system in total. A „bioethical standards“ charter might improve the level of local community environmental consciousness, and provide direction lines for its sustainable development (including a potential tourism-advertising ace card).]]></summary_en></project><project>
<id>3770</id><title_hr><![CDATA[Matematičko modeliranje i numeričke simulacije procesa u tankim i poroznim sredinama]]></title_hr><title_en><![CDATA[]]></title_en><user_id>817</user_id><user_firstLast_name>Igor Pažanin</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-7421</code><acronim><![CDATA[MaSiMo]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>22664</team_members_id><team_members_names><![CDATA[ Doktorand: Marko Radulović ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Mathematical modelling,Asymptotic analysis,Numerical simulations,Fluid flow,Homogenization, Boundary layer,Lubrication,Complex fluids,Porous medium]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[We frequently deal with systems described by the differential equations coming from conservation laws that are too complicated to be solved and are of limited use in practice. In many such situations the original physical laws can be replaced by empirical laws or other approximations derived on engineering level of rigor. Mathematical point of view requires justification of those models to see their validity, applicability and accuracy. That can be achieved theoretically by investigating the deviation from the original model, or numerically by comparing simulations with experimental data. Each approach, has its advantages and disadvantages and are, frequently, complementary. In the frame of MaSiMo project we will consider fluid flow through thin domains like pipes and fractures, as well as low permeability domains as porous media.The fluids are either Newtonian or micropolar, monophase or multiphase.  Physical processes in those fluids are convective, diffusive, dispersive or conductive, isothermal  or nonisothermal. Theoretical analysis is based on a priori estimates for governing differential equations, different notions of convergence and compactness. In particular asymptotic analysis and homogenization will be used.  For derivation of a priori estimates a powerful tool is the entropy dissipation method that is considered in this project in the context of nonlinear diffusion and population dynamics problems with a perspective of extension to other considered models. Proposed research is connected to many engineering disciplines, such as mechanical and petroleum engineering, hydrogeology etc. Expected results could improve engineering practice. In Croatian mathematical community  there is a significant  research in this field with several trained scientists. However,  they are dispersed in smaller groups. One of the aims of this project is formation of larger research group with focused scientific interests more competitive in a search for European grants.  ]]></summary_en></project><project>
<id>3771</id><title_hr><![CDATA[A panEuropean framework for strengthening Critical Infrastructure resilience to Climate Change ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>18910</user_id><user_firstLast_name>Kristian Horvath</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-3960</code><acronim><![CDATA[]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Geofizika, </scie_field_hr><scie_field_en>Geophysics, </scie_field_en><institution_hr><![CDATA[Ništa od navedenog]]></institution_hr><institution_en><![CDATA[Nothing from this list]]></institution_en><team_members_id>25087</team_members_id><team_members_names><![CDATA[ Doktorand: Sarah Ivušić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>3773</id><title_hr><![CDATA[Oscilatorna dinamika citoskeleta]]></title_hr><title_en><![CDATA[]]></title_en><user_id>11207</user_id><user_firstLast_name>Iva Tolić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-4389</code><acronim><![CDATA[OSCITON]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>21341</team_members_id><team_members_names><![CDATA[ Doktorand: Mihaela Jagrić ]]></team_members_names><keywords_hr><![CDATA[citoskelet, mikrotubuli, motorni proteini, diobeno vreteno, stanično kretanje, Rho GTPaze, mikroskopija, teorijsko modeliranje]]></keywords_hr><keywords_en><![CDATA[cytoskeleton, microtubules, motor proteins, mitotic spindle, cell migration, Rho GTPases, microscopy, theoretical modeling]]></keywords_en><summary_hr><![CDATA[Oscilacije u citoskeletu važne su za biologiju stanice kao sredstvo prostorne i vremenske regulacije stanične organizacije, diobe stanica i njihove pokretljivosti. U projektu OSCITON istraživat ćemo dva oscilatorna procesa. Kao prvo, proučavat ćemo mehanizam oscilacija kinetohora koje pokreću mikrotubuli tijekom mitoze, te utjecaj kinezina-8 na taj proces. Te oscilacije stvaraju sile napetosti između sestrinskih kinetohora, bez kojih stanica ne može proći kontrolnu točku u metafazi. Oscilacije ćemo proučavati uz pomoć naprednih tehnika svjetlosne mikroskopije u HeLa stanicama u kojima ćemo eksprimirati tubulin-GFP i kinetohorni protein mRFP-Cenp-B, te smanjiti ili pojačati ekspresiju kinezina-8. Da bismo proučavali sile koje djeluju na kinetohore, promijenit ćemo ravnotežu sila laserskom mikrodisekcijom mikrotubula vezanih na kinetohore. Paralelno s eksperimentima razvit ćemo teorijski model, koji će omogućiti interpretaciju utjecaja kinezina-8 na oscilacije. Kao drugo, proučavat ćemo oscilatornu repolarizaciju stanica Dictyostelium tijekom njihovog nasumičnog gibanja. Pretpostavljamo da kompeticija efektorskih kompleksa DGAP1/korteksilin i Scar/Wave za zajednički aktivator Rac1 igra središnju ulogu u repolarizaciji. Kako bismo testirali ovu hipotezu, koristit ćemo novu fluorescentnu sondu za aktivni Rac1, stanice s poremećenom ravnotežom efektorskih kompleksa, te stanice sa reduciranom funkcionalnošću proteina Rac1. Eksperimentalno i teorijski ćemo proučavati dinamiku Rac1, njegovih efektora, te F-aktina u stanicama divljeg tipa i mutiranih sojeva. Ovaj će interdisciplinarni projekt omogućiti optimalno korištenje resursa i okupiti znanstvenike s iskustvom u širokom rasponu disciplina od molekularne i stanične biologije, biokemije, mikroskopije do teorijske biofizike. Udruživanjem svih istraživača iz područja dinamike citoskeleta u Hrvatskoj okupit ćemo tim koji će igrati važnu ulogu u tom području istraživanja na međunarodnoj razini.]]></summary_hr><summary_en><![CDATA[Oscillations in the cytoskeleton are of general importance in cell biology as a means of spatial and temporal regulation of the cellular organization, cell division and motility. The project OSCITON focuses on two oscillatory processes. First, we will investigate the mechanism of microtubule-driven kinetochore oscillations during mitosis, and the role of kinesin-8 motors in this process. These oscillations generate tension between sister kinetochores, which is required to pass the spindle checkpoint. We will use HeLa cells expressing tubulin-GFP and mRFP-CENP-B, a kinetochore protein, in combination with advanced light microscopy and depletion or overexpression of kinesin-8 motors. To study the forces acting on kinetochores, we will perturb the force balance by performing laser microsurgery of the microtubules attached to kinetochores. The experiments will be accompanied by the development of a theoretical model, which will allow us to explore the role of kinesin-8 in the oscillations. Second, we will study the oscillatory repolarization of Dictyostelium cells during random migration. We propose that the competition of DGAP1/cortexillin and SCAR/Wave complexes for the common activator Rac1 plays a central role in this process. To test this hypothesis, we will use a novel fluorescent probe for active Rac1 GTPases, generate cells with disturbed balance of Rac1 effectors, and cells deficient in functional Rac1. Dynamics of the probes for Rac1, its effectors, and F-actin will be studied experimentally in live cells and theoretically. This interdisciplinary project is designed to optimize the use of resources and bring together researchers with the expertise in a range of disciplines, including molecular and cellular biology, biochemistry, microscopy, and theoretical biophysics. Through joining forces of all investigators of the cytoskeletal dynamics in Croatia, we intend to assemble a team that will play a prominent role in this field of research internationally.]]></summary_en></project><project>
<id>3775</id><title_hr><![CDATA[Električko nabijanje međupovršina na granici čvrsta faza/vodena otopina elektrolita]]></title_hr><title_en><![CDATA[]]></title_en><user_id>244</user_id><user_firstLast_name>Tajana Preočanin</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-6294</code><acronim><![CDATA[SAQUINT]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>22756</team_members_id><team_members_names><![CDATA[ Doktorand: Antun Barisic ]]></team_members_names><keywords_hr><![CDATA[električni međupovršinski sloj, površinske reakcije, površinski potencijal, metalni oksidi, polielektroliti, višeslojevi, kompleksiranje, nanočestice ]]></keywords_hr><keywords_en><![CDATA[electrical interfatial layer, surface reaction, surface potential, metal oxide, polyelectrolyites,multilayers, complexation, nanoparticles]]></keywords_en><summary_hr><![CDATA[Cilj je predloženog projekta istražiti procese koji se zbivaju na međupovršini čvrsta tvar/tekućina u svrhu boljeg razumijevanja interakcije površine mineralnih faza s molekulama vode, otopljenim ionima i složenim makromolekulama. Nove eksperimentalne metode omogućavaju karakterizaciju pojedinih kristalnih ploha te će se ispitati utjecaj strukture površine na nastajanje električkog međupovršinskog sloja. Za određivanje površinskog potencijala na 0-plohi pojedinih kristalnih ploha koristit će se monokristalne elektrode koje su po prvi put konstruirane u našem laboratoriju. Naime, upravo površinski potencijal na 0-plohi definira broj i vrstu površinskih specija na određenoj plohi, a time i ravnotežno stanje. Kombiniranjem podataka dobivenim mjerenjem površinskog potencijala na 0-plohi i elektrokinetičkog potencijala nastojat će se objasniti ravnotežni procesi koji se zbivaju na granici faza. Zanimljivu klasu površinskih reakcija čine procesi uzastopne naizmjenične adsorpcije polielektrolita suprotnog naboja na okside metala i polumetala. Navedeni procesi bit će istraženi u sklopu predloženog projekta. Dobiveni rezultati će se usporediti s rezultatima kompleksiranja polielektrolita u otopini. Naglasak u istraživanju bit će na specifičnom utjecaju protuiona na reakcije dvaju suprotno nabijenih polielektrolita. U konačnici rezultati dobiveni za pojedine plohe će se primijeniti na koloidne i nano čestice čija se površina sastoji od različitih kristalnih ploha. Interes za istraživanjem spomenutih nanostruktura i polielektrolita povezan je sa brojnim mogućnostima njihove primjene u industriji, odnosno razumijevanju uloge prirodnih polielektrolita i proteina u biološkim procesima. U svrhu izvođenja projekta koristit će se različite eksperimentalne metode, a za bolje razumijevanje procesa koje se zbivaju na međupovršinama i dobivanja kvantitativnog opisa specijacije svih vrsta koje sudjeluju u površinskim reakcijama, bit će razvijeni i odgovarajući teorijski modeli.]]></summary_hr><summary_en><![CDATA[In order to contribute to the understanding of basic interactions between the mineral phases and water molecules, ions and macromolecules we propose the investigations of processes at solid/liquid interfaces. Particular attention will be paid on a role of water, simple counterions and surface structure in formation of electrical interfacial layer. The single crystal electrode, device developed and constructed recently in our laboratory, will be used for determination of inner surface potential of specific crystal planes. Inner surface potential affects directly the state of ionic species bound to defined surface plane and is thus essential parameter governing interfacial equilibrium. The role of interfacial water in interfacial equilibrium will be analyzed by considering its behavior at inert surfaces but also at metal oxide surfaces. Finally, the results obtained for the particular crystal planes will be applied for colloids and nanoparticles exhibiting different crystal planes to the liquid medium. A special case of interfaces are polyelectrolytes at the metal oxide surface. Therefore, such interfaces and their correlation with the behaviour of polyelectrolytes in solution will be also extensively studied in the frame of the proposed project. The reason lies in fundamental interest to understand their properties in relation with the role of natural polyelectrolytes and proteins in biological processes, as well as in industrial applications. The latter are not limited to polyelectrolytes in solution, but include also the polyelectrolyte (or interpolyelectrolyte) complexes and multilayers. The formation of multilayers of polyelectrolytes at solid surfaces, as well as interpolyelectrolyte interactions in solution, will be examined. Special emphasis will be given on specific ionic effects. Predominantly the experimental methods will be applied, and theoretical tools will be developed in order to better understand behavior, reactivity and equilibrium at interfaces.]]></summary_en></project><project>
<id>3776</id><title_hr><![CDATA[SenseHive: Dinamički modeli za postepenu izgradnju leksičko-semantičkih resursa potpomognuti radom mnoštva]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6211</user_id><user_firstLast_name>Jan Šnajder</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-7301</code><acronim><![CDATA[SenseHive]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>18931</team_members_id><team_members_names><![CDATA[ Doktorand: Domagoj Alagić ]]></team_members_names><keywords_hr><![CDATA[Natural language processing, language technologies, lexical semantics, semantic resources, word sense disambiguation, Croatian language]]></keywords_hr><keywords_en><![CDATA[Obrada prirodnog jezika, jezične tehnologije, leksička semantika, semantički resursi, razrješavanje višeznačnosti, hrvatski jezik]]></keywords_en><summary_hr><![CDATA[Leksičko-semantički resursi igraju bitnu ulogu u obradi prirodnoga jezika i srodnih primjena poput pretraživanja informacija. Nažalost, njihova je  izgradnja izuzetno skupa te je rijetko vođena praktičnim potrebama, što kod jezika sa slabije razvijenim resursima predstavlja naročit problem. Moguće rješenje jest izgradnja leksičko-semantičkih resursa potpomognuta radom mnoštva (engl. crowdsourcing). Premda se rad mnoštva pokazao izvedivim i znatno povoljnijim pristupom, još uvijek ne postoji cjelovita metodologija koja bi omogućila postepenu izgradnju vrlo velikih leksičko-semantičkih resursa. Cilj ovoga projekta jest upotpuniti ovu prazninu i istražiti računalne modele i metode za postepenu i učinkovitu izgradnju leksičko-semantičkih resursa potpomognutu radom mnoštva. Istraživanje će objediniti modele za dinamičan rad mnoštva, modele semantike temeljene na korpusu (distribucijske modele i tematske modele) te aktivno strojno učenje, te polučiti cjelovit i jezično neovisan radni okvir, tzv. SenseHive. SenseHive objedinjuje prilagodiv prikaz značenja i leksičko-semantičkih veza riječi temeljen na grafovima (SenseGraph) i postupke za njegovu postepenu izgradnju. Značenja riječi dinamički se razdjeljuju i stapaju na temelju analize ljudskih ocjena dobivenih nad podatcima ekstrahiranima iz korpusa. U prvoj fazi projekta izgradit ćemo prototip i upotrijebiti ga za ciljane eksperimente na podatcima na hrvatskom, slovenskom i engleskom jeziku s ciljem odgovaranja na relevantna istraživačka pitanja. Kao dokaz koncepta, u drugoj ćemo fazi primijeniti SenseHive za izgradnju leksičko-semantičkog resursa za hrvatski jezik umjerene veličine, proširivanjem i obogaćivanjem postojećih leksičko-semantičkih resursa. Predloženo će istraživanje unaprijediti stanje znanosti u području računalne semantike i poluatomatske izgradnje jezičnih resursa te rezultirati konkretnim leksičko-semantičkim resursom za hrvatski jezik od velike praktične vrijednosti.]]></summary_hr><summary_en><![CDATA[Lexico-semantic resources play an essential role in natural language processing and related applications such as information retrieval. Unfortunately, their construction is extremely costly and rarely guided by practical considerations, posing a problem especially for less-resourced languages. One possible solution is to rely on crowdsourcing of lexico-semantic resources. Although crowdsourcing has proven to be a viable option for reducing the overall costs, there still does not exists a comprehensive crowdsourcing methodology for incremental construction of large-scale lexico-semantic resources. This projects aims to fill this gap by investigating the computational models and methods for incremental and cost-efficient crowdsourcing of lexico-semantic resources. The research will combine dynamic crowdsourcing, corpus-based models of semantics (distributional semantics and topic models), and active machine learning methods into a comprehensible and language-independent crowdsourcing framework, the SenseHive. The SenseHive consists of a flexible, graph-based representation of senses and lexico-semantic relations (SenseGraph), coupled with an incremental construction methodology. In SenseGraph, senses are dynamically split up and merged based on the analysis of human judgments on corpus-extracted data. In the first phase, we will implement a prototype of the SenseHive framework and use it for focused evaluation experiments on Croatian, Slovene, and English data to answer the relevant research questions. As a proof of concept, in the second phase we will use SenseHive to construct a medium-sized lexico-semantic resource for Croatian by enlarging and enriching existing lexico-semantic resources. The proposed research will advance the state of the art in computational lexical semantics and semi-automated construction of linguistic resources, and yield a lexico-semantic resource for Croatian of great practical value.]]></summary_en></project><project>
<id>3777</id><title_hr><![CDATA[Esencijalni metalni ioni u proteinima iz Helicobacter pylori i modelnim spojevima - struktura i funkcija/svojstvo]]></title_hr><title_en><![CDATA[]]></title_en><user_id>946</user_id><user_firstLast_name>Ivica Đilović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-1123</code><acronim><![CDATA[ProtModStruct]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>20946</team_members_id><team_members_names><![CDATA[ Doktorand: Kristina Smokrović ]]></team_members_names><keywords_hr><![CDATA[essential metals, model compounds, structural characterization, H. pylori proteins, chemical synthesis]]></keywords_hr><keywords_en><![CDATA[esencijalni metali, modelni spojevi, strukturna karakterizacija, proteini iz H. pylori, kemijska sinteza]]></keywords_en><summary_hr><![CDATA[U okviru istraživanja na ovom projektu želimo strukturno karakterizirati nekoliko proteina iz Helicobacter pylori (i odrediti njihovu funkciju) kao i modelne komplekse malih molekula sa esencijalnim metalnim ionima i biološki važnim ligandima (i odrediti njihova svojstva). Prioritetni će biti metali koji se nalaze u metaloproteinima iz H. Pylori.Svjetska zdravstvena organizacija proglasila je H. Pylori karcinogenom 1. klase te je važna meta istraživanja zbog svoje patogenosti. Proteini HypA i HypB su važni za pravilnu konstrukciju metalnog centra [Ni,Fe] hidrogenaze i urease. Proteini CrdA i CrdB potrebni su za održavanje koncentracije slobodnih iona bakra u citoplazmi ispod toksične razine. Namjeravamo klonirati, eksprimirati, pročistiti i karakterizirati kompleks HypA-HypB te proteine CrdA i CrdB biofizičkim i strukturnim metodama (termalna stabilnost, cirkularni dikroizam, određivanje konstante disocijacije bakrovog iona, rentgenska difrakcija, 3D NMR). Želimo odrediti funkciju metalošaperona u unutarstaničnoj regulaciji nikla (HypA-HypB) kao i mehanizam regulacije koncentracije bakra (CrdA, CrdB).Istraživati ćemo komplekse metala (bakra, nikla, željeza i drugih esencijalnih metala) s ciljem da odredimo preferirano koordinacijsko okruženje metala s aminokiselinama i derivatima aminokiselina (N-alkiliranih, amida, peptida, peptida bogatih metioninom i drugih) te dobijemo informaciju o specifičnosti aminokiselinskog ili peptidnog pokrajnjeg lanca prema različitim metalnim ionima. Komplekse ćemo sintetizirati te ih karakterizirati termičkim i spektroskopskim metodama i rentgenskom strukturnom analizom. Konstruirat ćemo konformacije bakrovih kompleksa s aminokiselinama te optimizirati njihovu geometriju pomoću kvantno-kemijskih proračuna da bismo istražili njihove moguće ravnotežne geometrije.]]></summary_hr><summary_en><![CDATA[Within this project we will structurally characterize several proteins from Helicobacter pylori (and reveal their functions) and small molecule model complexes of essential metal ions with biologically relevant ligands (and find their properties). The priority will be the essential metals involved in H. pylori metalloproteins.The World Health Organization has declared the H. pylori a Class 1 carcinogen and it is an important target for research due to its pathological relevance. H. pylori requires several accessory proteins such as HypA and HypB for the proper construction of the [Ni,Fe] hydrogenase and urease. The resistance determinants CrdA and CrdB are required for keeping the concentration of free copper ions in the cytoplasm below toxic levels. We plan to clone, express, purify and characterize the complex HypA-HypB and proteins CrdA and  CrdB by biophysical and structural methods (thermal stability assay, circular dichroism, determination of copper ion dissociation constant, X-ray diffraction, 3D NMR). We hope to determine how the metallochaperones exert their functions in intracellular nickel delivery (HypA-HypB) and the mechanism of copper level regulation (CrdA, CrdB).The aim of the study of the model complexes (with copper, nickel, iron, zinc and other essential metal ions) is to determine how these metals template their coordination environment by amino acids and their derivatives (N-alkylated, amides, peptides, methionine-rich peptides and others) and to obtain information on the specificity of amino acid or short peptide side chains toward different metal ions. The complexes will be synthesized and structurally characterized by thermal and spectroscopic analysis and X-ray crystal structure diffraction experiments.The conformations of the copper complexes with amino acids will be constructed and the geometry optimized to study their possible equilibrium geometries by quantum chemical calculations.]]></summary_en></project><project>
<id>3779</id><title_hr><![CDATA[Neuropathology of Sleep Apnoea]]></title_hr><title_en><![CDATA[]]></title_en><user_id>12653</user_id><user_firstLast_name>Dinko Mitrečić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-5568</code><acronim><![CDATA[]]></acronim><duration>01.11.2018 - 30.06.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>25396</team_members_id><team_members_names><![CDATA[ Doktorand: Damir Lisjak ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>3781</id><title_hr><![CDATA[Istraživanje školskog vođenja iz distributivne perspektive u hrvatskim školama]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4623</user_id><user_firstLast_name>Branko Rafajac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-4007</code><acronim><![CDATA[IScLEAD]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Pedagogija, </scie_field_hr><scie_field_en>Pedagogy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Filozofski fakultet u Rijeci]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>23308</team_members_id><team_members_names><![CDATA[ Doktorand: Adriana Ažić Bastalić ]]></team_members_names><keywords_hr><![CDATA[upravljanje obrazovnim sustavom, distributivno školsko vođenje, učinkovitost škola, jedinice lokalne samouprave, ravnatelji, učitelji, škole]]></keywords_hr><keywords_en><![CDATA[governance of educational system, distributive school leadership, school effectiveness, local educational authorities, school principals, teachers, sc]]></keywords_en><summary_hr><![CDATA[Predloženo istraživanje fokusira se na fenomen školskog vođenja koji se određuje kao jedan od najznačajnijih faktora uspješnosti škola odnosno postignuća učenika, a u širem kontekstu i uspješnosti odnosno održivosti obrazovnih reformi. Glavni cilj istraživanja je identificirati obilježja prakse školskog vođenja u hrvatskim školama s posebnim naglaskom na indikatore individualnog naspram distributivnog vođenja te iznalaženje onih obilježja školskog vođenja koja su povezana s učinkovitosti škola. Glavni cilj istraživanja realizirat će se kroz sljedeće specifične zadatke: 1) Ispitati obilježja školskog vođenja s posebnim naglaskom na ulogu i vrstu participacije i interakcija pojedinih dionika u aktivnostima vođenja (ravnatelja, školskog odbora, učiteljskog/nastavničkog vijeća, stručne službe, učitelja, roditelja, učenika, predstavnika zajednice i lokalne samouprave) i njihove povezanosti s indikatorima školskog uspjeha; 2) Ispitati različita obilježja upravljanja hrvatskim obrazovnim sustavom iz perspektive različitih dionika (komunikacija i suradnja između autoriteta na državnoj razini, razini lokalne samouprave i razini škole; zadovoljstvo načinom funkcioniranja obrazovnog sustava) i njihov efekt na praksu školskog vođenja. Rezultati prijašnjih istraživanja i preliminarni izvještaji povezani s hrvatskim obrazovnim sustavom ukazuju na važnost osnaživanja karakteristika distributivnog školskog vođenja s naglaskom na osnaživanje kapaciteta učitelja kao aktivnih sudionika u procesu donošenja odluka koje se odnose na obrazovanje. ]]></summary_hr><summary_en><![CDATA[The proposed research focuses on the phenomenon of school leadership which is seen as one of the most important success factors of school and student achievement. In the broader context, it is seen as a success i.e. sustainability factor of education reforms. The main aim of this research is to identify the characteristics of the school leadership practice in Croatian schools with the special emphasize on indicators of both solo and distributive leadership and finding those features that are associated with the school and student achievement. The main aim will be elaborated through the following specific tasks: 1) examining the characteristics of school leadership with special emphasis on the role of participation and interaction of individual stakeholders in the activities of leadership (school principals, school boards, school councils, professional services, teachers, parents, students, community representatives and local government) and their association with indicators of school success; 2) examining various features of education system governance from the perspectives of different stakeholders (communication and collaboration between state level, local governments and school level authorities; overall satisfaction with the education system governance) and their effects on the school leadership practice. Results of the previous studies and preliminary review related to Croatian education system point to the importance of strengthening the characteristics of the distributed school leadership with special emphasis on strengthening the capacity of teachers as active participants in making key decisions related to the matters of education.]]></summary_en></project><project>
<id>3782</id><title_hr><![CDATA[Diracovi operatori i teorija reprezentacija]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5573</user_id><user_firstLast_name>Pavle Pandzic</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-5710</code><acronim><![CDATA[representations]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>22605</team_members_id><team_members_names><![CDATA[ Doktorand: Josip Grgurić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Harish-Chandra modules, Dirac operators, cohomology, Dirac induction, branching problems]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Dirac operators were introduced into representation theory by Parthasarathy in the 1970s. In the 1990s, Vogan conjectured a strengthening of Parthasarathy&#39;s Dirac inequality, which relates the cohomology of the Dirac operator to the infinitesimal character of the representation. This conjecture was proved in a joint paper with Huang . In further research, in part joint with various collaborators (Barbasch, Huang, Kang, Mehdi, Protsak, Renard, Somberg, Zhu) , we related Dirac cohomology to other kinds of cohomology, calculated it explicitly for many interesting representations, and studied algebraic Dirac induction, a construction of representations with given Dirac cohomology. The proposed project will continue this research in several directions: 1) the study of representations obtained by Dirac induction, in particular the discrete series representations (doctoral research of Ana Prlić). 2) applying Dirac cohomology to problems of restricting representations. Some instances of this have been studied with Huang-Zhu and with Somberg. 3) trying to strengthen the Dirac inequality, which should have implications for the study of unitary representations. Some preliminary work on  the convex hull conjecture of Salamanca-Vogan has been done with Renard. 4) calculating the Dirac cohomology of  unipotent representations. Some cases of this have been obtained jointly with Barbasch. This could lead to better understanding of characters of unipotent representations, which is related to the Assem conjecture. It would also be interesting to calculate the Dirac cohomology of unitary highest weight modules. Other topics we plan to cover include studying translation principle for Dirac index (joint with Mehdi and Vogan); studying n-cohomology and BGG resolutions using Penrose transforms (joint with Soucek);  studying some abstract homotopy and homology theory, with applications to tensor categories of representations (doctoral research of Matija Bašić).]]></summary_en></project><project>
<id>3784</id><title_hr><![CDATA[Sinteza, strukturna analiza i biološka evaluacija peptidomimetika i glikokonjugata ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>569</user_id><user_firstLast_name>Srđanka Tomić-Pisarović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-7312</code><acronim><![CDATA[PEPTGLYCOSAR]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>22776</team_members_id><team_members_names><![CDATA[ Doktorand: Nora Tir ]]></team_members_names><keywords_hr><![CDATA[peptidomimetici, peptidoglikan, feroceni, manokonjugati, bioaktivnost]]></keywords_hr><keywords_en><![CDATA[peptidomimetics, peptidoglycan, ferrocenes, mannoconjugates, bioactivity]]></keywords_en><summary_hr><![CDATA[Osnovni cilj ovog projektnog prijedloga je sinteza, strukturna analiza i biološka evaluacija dvije vrste novih peptidomimetika: (i) peptidnih spojeva peptidoglikanskog tipa s imunomodulacijskim djelovanjem, u svrhu ispitivanja njihove interakcije sa specifičnim receptorima te (ii) peptidnih konjugata s ferocenom, s kiralno organiziranim strukturama ostvarenima povezivanjem intramolekulskim vodikovim vezama, a koje su preduvjet za stvaranje 3D struktura i funkcioniranje bioloških sustava. Također će se pripraviti glikokonjugati tih spojeva te će se proučavati njihova biološka svojstva. Naglasak će biti na manokonjugatima obzirom da je to jedan od monosaharida kojeg prepoznaju specifični receptori na površini stanica. Manozilirani peptidoglikanski fragmenti s adamantanskom podstrukturom ugrađivati će se u liposome na način da manozne jedinice budu na njihovoj površini kako bi bile dostupne za manozne receptore na stanicama imunološkog sustava. Sljedeći je cilj ovog projektnog prijedloga sinteza peptidoglikanskih fragmenata s ugrađenom ferocenskom podjedinicom te pručavanje konformacija tih molekula. Ferocenski alfa-manozidi ispitat će se pomoću testa inhibicije hemaglutinacije kao potencijalni inhibitori infekcije koju uzrokuje Escerichia coli. Ova istraživanja proširit će se i na alfa-manozide heterocikličkih spojeva kao što su 3-hidroksipiridin-4-oni, imidazolijevi i benzimidazolijevi derivati, koji su česti sastavni dijelovi spojeva sa širokim spektrom bioloških djelovanja. Biološka evaluacija svih pripravljenih spojeva ovog projektnog prijedloga provoditi će se, jednim svojim dijelom, u suradničkim institucijama u svrhu korelacije struktura derivata s njihovom biološkom aktivnošću. Studije molekulskog modeliranja koristit će se za predviđanje strukturnih promjena u svrhu poboljšanja aktivnosti.]]></summary_hr><summary_en><![CDATA[In this project proposal the main goal is the synthesis, structural characterization and biological evaluation of novel peptidomimetics of two types: (i) peptidoglycan derived peptides possessing immunomodulating activity in order to study their interactions with specific receptors and (ii) ferrocene-peptide conjugates which comprise an efficient bioorganometallic constraint designed to induce chirally organized structures through intramolecular hydrogen bonding as a prerequisite for 3D structure formation and function of biological systems. Glycoconjugates of these compounds will be prepared and their biological properties studied with emphasis on mannoconjugates since mannose is one of the carbohydrates recognized by receptors on cell surfaces. Mannosylated peptidoglycan fragments with the adamantane moiety will be incorporated into liposomes with mannose exposed at the surface serving in targeting mannose receptors on immune cells. Furthermore, peptidoglycan fragments will be modified with the ferrocenyl moiety and their conformational properties studied. Alpha-mannoside derivatives of these compounds will be also investigated as possible inhibitors of infections caused by Escerichia coli using the hemagglutination test. These studies will be extended to alpha-mannoside derivatives of heterocyclic compounds such as 3-hydroxypyridine-4-ones, imidazoles and benzimidazoles which are common parts of substances with a broad spectrum of biological activities. Screening and evaluation of biological properties of all compounds to be synthesized will be performed, partly in collaborative institutions. Molecular modelling will be used in predicting structural changes leading to improved biological activities. ]]></summary_en></project><project>
<id>3788</id><title_hr><![CDATA[Definiranje mogućnosti uporabe mini dentalnih implantata (MDI) i njihovi rezultati u in vitro i u kliničkim prospektivnim istraživanjima]]></title_hr><title_en><![CDATA[]]></title_en><user_id>7709</user_id><user_firstLast_name>Asja Čelebić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-8878</code><acronim><![CDATA[Mini implantati/ MDI]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Dentalna medicina, </scie_field_hr><scie_field_en>Dental medicine, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu]]></institution_hr><institution_en><![CDATA[University of Zagreb]]></institution_en><team_members_id>22616</team_members_id><team_members_names><![CDATA[ Doktorand: Ines Kovačić ]]></team_members_names><keywords_hr><![CDATA[Mini dentalni implantati, standardni implantati, mehanička teastiranja na modelima, klinička prospektivna istraživanja, određivanje indikacija za MDI]]></keywords_hr><keywords_en><![CDATA[Mini dental implants, standard implants, mechanical testing on models, clinical prospective studies, MDI indications]]></keywords_en><summary_hr><![CDATA[Mini dentalni implantati (MDI) su jednokomadni uski implantati za privremenu (ortodoncija, privremeni mostovi) ili za dugoročnu kliničku upotrebu. Prednosti MDI za trajnu kliničku primjenu su u njihovoj niskoj cijeni i jednostavnoj proceduri. Iako na dentalnom tržištu postoje već 10 godina, dokazi o budućim kliničkim istraživanjima za definiranje njihovih kliničkih protokola i njihovom dugoročnom ishodu nedostaju. Stoga planiramo istraživati njihova mehanička svojstva na modelima s obzirom na moment sile prilikom insercije, mogućnost loma prilikom cikličkih opterećenja ili  opterećenja prilikom naprezanja. Situacija slična stanju u ustima  će se simulirati pomoću različitih kosti tvrdoće modela (guste vs kosti niske gustoće) s 2 vrste sluznice  različite širine, te insercijom  1, 2, 3 ili 4 MDI različite širine i dužine za retenciju pokrovne proteze. 3 D printevi služiti će da bi se razvili modeli na kojima će se testirati. Nadalje, buduće kliničke studije koje će se temeljiti na pacijentovoj procjeni ishoda terapije (pomoću psihometrijski odobrenih upitnika) i kliničkih parametara (preživljavanje implantata, komplikacije, razina kosti oko implantata, resorpcija na stražnjim bezubim dijelovima ispod baze proteze, kortikalni indeksi na donjem rubu mandibule, vrijednosti gonion i antegonion udubina, gustoća kostiju u područjima interesa koji će biti izraženi u debljini stepwedga, mjerenje plak, gingiva i kalkulus indeksa, ISQ vrijednosti) će također biti predmetom istraživanja. Podaci će se upoređivati sa onima dobivenim nakon jedne i 3 godine.  Rezulati dobiveni temeljem pacijentove procjene usporediti će se s kliničkim dobivenim parametrima. Nadalje, rezultati dobiveni s obzirom na kliničke parametre kod pacijenata sa MDI (kvaliteta kostiju, količina, gustoća) će se uspoređivati sa podacima kod pacijenata sa potpunim protezama, kod pacijenata sa pokrovnim proteze na 2-standardna implantata te kod  osoba s prirodnim zubala. Također će se proučavati različite mogućnosti retencije proteza (mehanizmi).]]></summary_hr><summary_en><![CDATA[Mini dental implants (MDIs) are one piece slim implants for temporary (orthodontics, temporary bridges) or for a long term clinical use. Advantages of MDIs for a permanent clinical use are their low cost and simple procedures. Although they exist at the dental market for 10 years, evidence based prospective clinical studies for definition of their clinical protocols and long term outcomes are missing. Therefore we plan to study first their mechanical properties on models considering placement torque, fracture torque, possibility of fracture upon cycling loads or strain loads. A situation similar to real one will be simulated by using different bone hardness models (dense vs, low density bone) with 2 different oral mucosa widths, and with insertion of 1, 2, 3 or 4 MDIs of different width and length for overdenture retention. 3D prints will be helpful in model development. Further, prospective clinical studies based on both, patient based outcomes (assessed by psychometrically approved questionnaires) and clinical parameters (implant survival, any complications, bone level adjecent to implants, bone resorption at posterior edentulous sites under a denture base, cortical indices changes at the low border of the mandible, gonion angle and antegonion pitch values, bone density in the region of interest expressed as equvivalents of actual Cu stepwedge thickness attached during exposure, plaque, gingival and calculus indices, ISQ values) will be performed. Baseline data will be compared to a 1-year and 3-year outcomes. Patient based outcomes will be compared with clinical data. Results considering clinical parameters (bone quality, quantity, density) will be compared to similar data in complete denture wearers, in overdenture patients with dentures retained by 2-standard size implants and in individuals with natural dentition. Different denture retention options (mechanisms) will also be studied.]]></summary_en></project><project>
<id>3790</id><title_hr><![CDATA[TERAPIJSKI POTENCIJAL ORALNE GALAKTOZE U EKSPERIMENTALNOJ ALZHEIMEROVOJ BOLESTI]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1198</user_id><user_firstLast_name>Melita Šalković-Petrišić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-5041</code><acronim><![CDATA[GALAD]]></acronim><duration>16.01.2017 - 27.02.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>22452</team_members_id><team_members_names><![CDATA[ Doktorand: Ana Babić ]]></team_members_names><keywords_hr><![CDATA[oralna galaktoza, streptozotocin, transgenični Tg2576 miševi, Alzheimerova bolest, glukagonu sličan peptid-1]]></keywords_hr><keywords_en><![CDATA[oral galactose, streptozotocin, transgenic Tg2576 mice, Alzheimer&#39;s disease, glucagone-like peptide-1]]></keywords_en><summary_hr><![CDATA[Cilj istraživanje je ispitati novi terapijski pristup Alzheimerovoj bolesti (AB), kao najčešćem obliku demencije. Porastom dokaza o inzulinskoj rezistenciji u mozgu (IRM) i cerebralnom metaboličkom poremećaju kao medijatorima sporadične AB (sAB), normaliziranje inzulinske signalizacije i posljedičnih poremećaja u mozgu postali su novi ciljevi u liječenja AB. Poseban doprinos istraživanja je karakterizacija terapijskog potencijala oralno primijenjene galaktoze u životinjskim modelima koji oponašaju sAB i familijarnu AB. Model za sAB su štakori s intracerebroventrikularnom primjenom streptozotocina (STZ-icv model) koja inducira nastajanje IRM i vremenom pojavu mnogih sAB-u sličnih obilježja. Model za familijarnu AB su transgenični Tg2576 miševi koji vremenom pokazuju neke od znakova IRM. Galaktoza je alternativni izvor energije; ulazi u stanice inzulin-neovisnim nosačem za glukozu GLUT3 i metabolizira se u glukozu. Nedavni rad glavnog ispitivača pokazao je da oralna galaktoza sprečava nastajanje kognitivnih deficita u štakorskom STZ-icv modelu. Ovo će istraživanja ispitati sprečava li ih u Tg2576 miševa te ublažava li već nastale kognitivne deficite u oba modela. Inovativni aspekt projekta je u rasvjetljavanju učinaka posredovanih oralnom galaktozom; poboljšanja cerebralnog unosa glukoze i stimulacije sekrecije glukagonu-sličnog peptida-1 (GLP-1) te njihove korelacije s kognitivnim poboljšanjem. Za utvrđivanje učinka 2-mjesečne primjene oralne galaktoze na poremećaje pamćenja koristit će se Morris Water Maze i Passive Avoidance testovi, radio-obilježenim ligandom pratit će se metabolizam glukoze u mozgu, dok će se Western blot analizom, imunohistokemijom i enzimskim imunoadsorpcijskim testom odrediti razina GLUT3/GLUT4 i inzulin-razgrađujućeg enzima, tau i amiloidna patologija u mozgu te količina galaktoze, inzulina i GLP-1 u plazmi i likvoru. Rezultati projekta generirat će nove spoznaje i omogućiti značajan uvid u novi, na nutrijentu temeljeni pristup liječenju AB.]]></summary_hr><summary_en><![CDATA[This project aims to explore a novel therapeutic strategy in Alzheimer’s disease (AD), the most common form of dementia. Owing to growing evidence of brain insulin resistance (BIR) and cerebral metabolic dysfunction being the mediators of sporadic AD (sAD), restoring of brain insulin signalling and downstream defects has recently become a new target in AD treatment research. Unique contribution of this proposal is in characterization of the therapeutic potential of oral galactose in animal models which mimic sAD and familial AD. The former is generated by streptozotocin-intracerebroventricular application (STZ-icv rat) which induces BIR and eventually develops many of sAD-like features, and the latter is transgenic Tg2576 mice which eventually show some signs of BIR. Galactose is alternative source of energy; it enters the cell via insulin-independent glucose transporter GLUT3 and is metabolized to glucose. PI’s recent publication indicates that oral galactose prevents development of cognitive deficits in STZ-icv rat model. This research will explore if it can prevent them in Tg2576 mice and ameliorate already developed cognitive deficits in both Tg2576 mice and STZ-icv rats. Innovative aspect of the proposal is elucidation of oral galactose-mediated improvement in cerebral glucose uptake and stimulation of glucagone-like peptide-1 (GLP-1) secretion, and their correlation to cognitive improvement in both models. Morris Water Maze and Passive Avoidance tests, radio-tracing of brain glucose metabolism, Western blot analysis, Enzyme-Linked Immunosorbent Assays and immunohistochemistry will be used to detect effects of 2-month oral galactose treatment on memory loss, GLUT3/GLUT4 and insulin degrading enzyme levels, tau and amyloid-ß pathology in the brain, and galactose, insulin and GLP-1 levels in blood/cerebrospinal fluid. Project results will gain new knowledge and provide significant insights into a novel nutrient-related therapeutic strategy in AD treatment.]]></summary_en></project><project>
<id>3792</id><title_hr><![CDATA[Mehanokemijska reaktivnost pod kontroliranim uvjetima temperature i atmosfere za čistu sintezu funkcionalnih materijala]]></title_hr><title_en><![CDATA[]]></title_en><user_id>625</user_id><user_firstLast_name>Ivan Halasz</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-6424</code><acronim><![CDATA[MECHANOCONTROL]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>21253</team_members_id><team_members_names><![CDATA[ Doktorand: Stipe Lukin ]]></team_members_names><keywords_hr><![CDATA[mehanokemijska sinteza, reaktivnost u čvrstom stanju, in situ monitoring, templatiranje i adsorpcija plinova, funkcionalizacija metal-ugljik veze]]></keywords_hr><keywords_en><![CDATA[mechanochemical synthesis, solid-state reactivity , in situ monitoring, gas-templation and adsorption, functionalization of metal-carbon bond]]></keywords_en><summary_hr><![CDATA[Mehanokemijske reakcije su se nametnule u posljednje vrijeme kao brza i ekološki prihvatljiva alternativa konvencionalnoj kemijskoj sintezi u velikom broju područja, od sinteze nanomaterijala i slitina do supramolekulskih organskih materijala i koordinacijskih mreža. Područje se posebno razvilo uvođenjem novih tehnika, tekućinom potpomognutog mljevenja ili ionima- i tekućinom potpomognutog mljevenja, koji uključuju dodatak aditiva u reakcijske smjese. Unatoč velikom broju objavljenih radova, načini kontrole osnovnih reakcijskih uvjeta, poput temperature i tlaka unutar mehanokemijskog reaktora, još uvijek nisu uvedeni u standardne mehanokemijske postupke. Štoviše, znanja o utjecaju reakcijskih uvjeta i aditiva na mehanizme reakcija mljevenja su još na spekulativnom nivou.Glavni cilj predloženog projekta je istraživanje fundamentalnih aspekata mehanokemijskih reakcija pod kontroliranom tlakom i u određenom rasponu temperatura. Okolišno relevantni plinovi (poput ugljikova(IV) oksida, metana, sumporovih i dušikovih oksida) će se koristiti kao templati ili reaktanti za sintezu poroznih koordinacijskih spojeva ili organskih spojeva. Također, ispitati će se vezanje plinova na neporozne koordinacijske spojeve, te funkcionalizacija ugljikovih atoma iz organometalnih spojeva.Da bismo uspješno ostvarili ciljeve projekta, razviti ćemo mehanokemijske reaktore u kojima će biti moguće kontrolirati temperaturu i tlak. Mehanistički aspekti mehanokemijskih reakcija između plinova i krutina biti će određeni in situ tehnikama praćenja nedavno razvijenih unutar naše grupe.Iskustvo i saznanja prikupljeni implementacijom ovoga projekta će se iskoristiti za istraživanja mehanokemijske sinteze ciljanih materijala, a s krajnjim ciljem stjecanja dubljeg uvida u mehanokemijske reakcije i proširenja  potencijala za njihovu primjenu. Očekujemo da će rezultati projekta imati snažan utjecaj na korištenje reakcija u čvrstom stanju, kako u istraživačkim laboratorijima, tako i u kemijskoj industriji.]]></summary_hr><summary_en><![CDATA[Mechanochemical reactions by milling have recently emerged as excellent, rapid and cleaner alternative to conventional solution synthesis in a number of areas, from nanomaterials and alloys to supramolecular, organic materials and metal-organic frameworks. The area flourished after the introduction of new techniques, liquid-assisted grinding and ion- and liquid assisted grinding, involving additives in the reaction mixtures. Despite a growing rate of published articles, the means of controlling the basic milling reaction conditions, such as temperature and pressure in the vessel, is still not a part of standard milling procedures. Moreover, understanding of the effect of reaction conditions and additives on milling-reaction mechanisms is currently on speculative level.The main objective of this project proposal is to explore fundamental aspects of mechanochemical solid-state reactions under controlled pressure and in a range of temperatures. We will employ different gases (with special focus on environmentally relevant gases such as carbon dioxide, methane and sulfur- or nitric oxides) as reacting agents and templates for the synthesis of porous metal-organic and covalent organic frameworks, to selectively bind pollutant gases to nonporous coordination compounds or to functionalize carbon atoms in organometallic compounds. To successfully implement the objectives of this project proposal, we will develop milling vessels where the described reaction conditions can be achieved. Mechanistic aspects of gas-solid milling reactions will be studied by our novel in situ and real-time monitoring techniques.The experience and knowledge acquired by the project implementation will be applied to mechanochemical formation of target materials in order to broaden understanding and application scope of mechanochemical reactivity. The project results are expected to have a strong transformative effect on solid-state reactivity in a research laboratory as well as in chemical industry.]]></summary_en></project><project>
<id>3793</id><title_hr><![CDATA[Zelena sinteza organopaladijevih foto-osjetljivih spojeva]]></title_hr><title_en><![CDATA[]]></title_en><user_id>112</user_id><user_firstLast_name>Manda Ćurić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-6974</code><acronim><![CDATA[GREENSENS]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>21286</team_members_id><team_members_names><![CDATA[ Doktorand: Alen Bjelopetrović ]]></team_members_names><keywords_hr><![CDATA[mehanokemija, starenje, aktivacija C-H veze, mehanizam, spektroskopija, neinvazivni kromogeni i fluorogeni kemosenzori  ]]></keywords_hr><keywords_en><![CDATA[mechanochemistry, aging, C-H bond activation, organopalladium, mechanism, spectroscopy, non-invasive chromogenic and fluorogenic chemosensors]]></keywords_en><summary_hr><![CDATA[Zelena kemija je na čelu aktualnih zbivanja raznih istraživačkih područja u kemiji. Jedan od njezinih glavnih ciljeva je razvijanje učinkovitih preparativnih metoda za različite vrste postojećih i novih kemikalija bez korištenja otapala i uz nisku potrošnju energije. Izvedivost ovog temeljnog koncepta zelene kemije bit će pokazana na sintezi organopaladijevih kompleksa te će većina sintetskih koraka u ovom projektu biti provedena reakcijama u čvrstom stanju, upotrebom metoda ubrzanog starenja i mehanokemije. Prvu mehanosintezu organopaladijevih spojeva aktivacijom C-H veze paladijevim(II) acetatom nedavno je objavila naša grupa. Valja napomenuti da je aktivacija C-H veze od iznimne važnosti u sintetskoj organskoj kemiji. U okviru ovog projekta predlažemo razvijanje i primjenu metoda u čvrstom stanju za sintezu niza ciklopaladiranih aromatskih azo spojeva. Interes za organopalladijeve komplekse s konjugiranim C=C and N=N vezama proizlazi iz njihove jake apsorpcije i emisije svijetla u području niskih energija što ih kvalificira kao dobre kandidate za biomolekulske obilježivače. U tom pogledu, njihov afinitet prema ciljanim amino kiselinama, kratkim peptidima i nukleobazama istražit će se UV-vis and fluorescentnom spektroskopijom. Shodno navedenom, dodatna korist od predloženog projekta bit će niz novih kromogenih i fluorogenih kemosenzora.Struktura produkata u čvrstom stanju odredit će se rendgenskom difrakcijom, NMR, Raman i IR spektroskopijama. Mehanizam ciklopaladacije u čvrstom stanju istražit će se u realnom vremenu in situ praćenjem reakcija Raman spektroskopijom, te u otopini UV-vis i NMR spektroskopijama uz ESI spektrometriju masa. Optička svojstva kompleksa u čvrstom stanju i otopini odredit će se UV-vis and fluoroscentnom spektroskopijom. Eksperimentalni rezultati racionalizirat će se teorijskim istraživanjima da bi se objasnila izomerija kompleksa, priroda njihovih elektronskih prijelaza te da bi se dobila dodatna potvrda za mehanizam ciklopaladacije.]]></summary_hr><summary_en><![CDATA[Green chemistry is at the forefront of current developments of various research areas in chemistry. One of its major objectives is to develop efficient solvent-free and low-energy preparative methods for various classes of existing and new chemicals. The feasibility of this green-chemistry concept will be demonstrated on the synthesis of organopalladium complexes and the majority of synthetic steps in this project will be performed in the solid state by methods of accelerated aging and mechanochemistry. The first mechanosynthesis of organopalladium compounds via C-H bond activation, which is of exceptional importance in organic synthesis, by palladium(II) acetate has been recently reported by our group.Within this project we propose to develop and implement the solid-state methods for the synthesis of a series of cyclopalladated aromatic azo compounds. Interest in such complexes with conjugated C=C and N=N bonds arises from their strong absorption and emission in the low energy region, which qualifies them as good candidates for the biomolecular labels. In this regard, their affinity to target amino acids, short peptides and nucleobases will be studied by UV-vis and fluorescence spectroscopies. Consequently, an additional benefit of this project will be a series of new chromogenic and fluorogenic chemosensors.The solid-state structures of the products will be determined by X-ray diffraction, NMR, Raman and IR spectroscopies. The cyclopalladation mechanism in the solid state will be studied by in situ monitoring of the reactions using Raman spectroscopy, and in the solution by UV-vis and NMR spectroscopies along with the ESI mass spectrometry. The optical characteristics of complexes will be evaluated by UV-vis and fluorescence spectroscopies. The experimental results will be rationalized by theoretical studies in order to explain isomerism of complexes, the nature of their electronic transitions and to obtain additional support for the cyclopalladation mechanism.]]></summary_en></project><project>
<id>3794</id><title_hr><![CDATA[Integracijski procesi većine i manjine u etnički mješovitim zajednicama: uloga međuetničkog kontakta, percipirane prijetnje i socijalnih normi]]></title_hr><title_en><![CDATA[]]></title_en><user_id>11126</user_id><user_firstLast_name>Dinka Čorkalo Biruški</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-2477</code><acronim><![CDATA[IntegraNorm]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Psihologija, </scie_field_hr><scie_field_en>Psychology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>20453</team_members_id><team_members_names><![CDATA[ Doktorand: Lana Pehar ]]></team_members_names><keywords_hr><![CDATA[socijalna integracija, odnosi većine i manjine, međuetnički kontakt, međugrupna prijetnja, socijalne norme, obrazovanje manjina]]></keywords_hr><keywords_en><![CDATA[social integration, majority and minority relations, interethnic contact, intergroup threat, social norms, minority education]]></keywords_en><summary_hr><![CDATA[Cilj projekta je ispitati dugoročne efekte međuetničkog kontakta na ideološke i međuetničke stavove i ponašanja djece, adolescenata i njihovih roditelja, pripadnika većine i manjina, u četiri višeetničke zajednice u Republici Hrvatskoj. Jedinstven kontekst ispitivanja su manjinske i većinske škole, u kojima se nastava odvija na manjinskom jeziku (srpski, talijanski, mađarski i češki) ili pak na jeziku većine (hrvatski), a uključivanje čak četiri manjinske zajednice čini projektni prijedlog sasvim originalnim. Kao mogući mehanizmi djelovanja kontakta na međugrupne stavove i ponašanja istražit će se međugrupna prijetnja (realna i simbolička, te međugrupna tjeskoba), te, posebno, socijalne norme. Istraživanje predstavlja iskorak, jer zahvaća nekoliko aspekata međugrupne prijetnje kao posredujućeg mehanizma u odnosu međugrupnog kontakta i međugrupnih stavova i ponašanja, kao i temeljne izvore utjecaja u djece i adolescenata - roditeljske, vršnjačke i školske norme. U istraživanju će sudjelovati učenici osnovne i srednje škole, pripadnici četiri nacionalne manjine u Republici Hrvatskoj (Srbi, Talijani, Česi, Mađari) i većine, u dobi od 12 do 17 godina (N=1200) i njihovi roditelji (N=2400). Istraživanje kombinira kvalitativni i kvantitativni pristup. Kvalitativnom metodologijom (fokusne grupe, intervjui, ali i metoda opažanja) ispitat će se eksplicitne i implicitne školske norme o međuetničkom kontaktu, te potom formulirati instrument za njihovo mjerenje. Kvantitativni dio ispitivanja provest će se u dva vala, s razmakom od godine dana, te će se pratiti efekti međuetničkog kontakta na ideološke (stav prema multikulturnosti i asimilaciji), i na međugrupne stavove i ponašanja. Pri tome će se provjeriti pod kojim uvjetima, kako i koje socijalne norme utječu na vezu kontakta i međugrupnih stavova i ponašanja, te kakva je pri tome uloga međugrupne prijetnje. Rezultati projekta mogu biti relevantni za osmišljavanje integracijske uloge škole u višeetničkim zajednicama.]]></summary_hr><summary_en><![CDATA[The study aims to examine long-term effects of interethnic contact on ideological and interethnic attitudes and behaviors of majority and minority children, adolescents and their parents in four multiethnic communities in Croatia. A unique context of the study is provided by setting the research in the context of minority and majority schooling, where teaching is provided in either majority (Croatian) or minority languages (Italian, Serbian, Czech and Hungarian). Inclusion of multiple minority communities simultaneously makes this project sample rather unique. Intergroup threat (symbolic, realistic and intergroup anxiety) and especially social norms are hypothesized as being key mechanisms of influence of the interethnic contact. A novelty of the research is in encompassing multiple aspects of intergroup threat as mediating mechanisms in the link between intergroup contact and intergroup attitudes and behaviors, as well as and in assessing major sources of influence in adolescence – parental, peer and school norms. Participants will be majority and minority (Italian, Serb, Czech and Hungary) elementary and high-school students in Croatia, aged 12-17 (N=1200) and their parents (N=2400). The research combines qualitative and quantitative approach. Qualitative methods (focus groups, interviews and also observations) will be used to get an in-depth insight in the explicit and implicit contact-related school norms. These data will be used further for designing an instrument for measuring contact-related school norms. Quantitative data will be collected in a two-wave longitudinal study, and the effects of interethnic contact on ideological (assimilationism and multiculturalism) and intergroup attitudes and behaviors will be followed. It is proposed to test under what conditions, how and what social norms influence the link between the contact and intergroup attitudes and behaviors and what is the role of the intergroup threat in this context.]]></summary_en></project><project>
<id>3795</id><title_hr><![CDATA[Molekularni posrednici koštane resorpcije uvjetovane receptorom Fas u artritisu ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3882</user_id><user_firstLast_name>Nataša Kovačić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-9897</code><acronim><![CDATA[MEFRA]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>21249</team_members_id><team_members_names><![CDATA[ Doktorand: Nina Lukač ]]></team_members_names><keywords_hr><![CDATA[artritis, Fas, osteoresorpcija, stanična loza, diferencijacija, apoptoza, upala]]></keywords_hr><keywords_en><![CDATA[arthritis, Fas, osteoresorption, lineage, differentiation, apoptosis, inflammation]]></keywords_en><summary_hr><![CDATA[Upalni artritisi su kronične zglobne bolesti, i važan zdravstveni problem zbog progresivne invalidnosti. Najčešći je reumatoidni arthritis (RA) praćen oštećenjem kosti i hrskavice, koji dovode do trajnih deformacija zgloba. Artritis se također često javlja tijekom sistemskog lupusa eritematosusa (SLE), uglavnom kao neerozivni artritis.Tijekom RA, upalne i imunološke stanice stvaraju mikrookoliš koji izaziva resorpciju kosti, potičući sazrijevanje i aktivnost osteoklasta, a kočeći sazrijevanje i aktivnost osteoblasta. Lijekovima poput bioloških sredstava može se promijeniti tijek bolesti, ali ograničeno je djelovanje na koštanu resorpciju. Sustav Fas/Fas ligand važan je regulatore homeostaze imunološkog sustava, a sve je više dokaza  o njegovoj važnosti u regulaciji koštane homeostaze. Inaktivacija receptora Fas štiti od gubitka kosti izazvanog nedostatkom estrogena, ali i gubitka kosti u upalnom artritisu, međutim stanične loze i signalni putevi koji posreduju taj učinak još nisu u potpunosti poznati. Korištenjem modela artritisa potaknutog antigenom (AIA, prema engl. antigen-induced arthritis) u miševa s izbačenim genom za Fas, te uzoraka sinovijalne tekućine bolesnika s RA i SLE, namjeravamo istražiti fenotip staničnih populacija odgovornih za kočenje osteoresorptivnih zbivanja, te utvrditi funkcijske promjene u tim stanicama globalnom analizom njihovog genskog izražaja. Nadalje, očekujemo da ćemo potvrditi značaj promijenjenih gena/bjelančevina njihovom inaktivacijom in vivo u mišjem modelu AIA, a važnost pojedine loze utvrdit ćemo uporabom miševa sa izbačenim genom za Fas u toj lozi. Analiza ljudskih uzoraka omogućit će razumijevanje značenja navedenih promjena u kliničkoj primjeni.   Naš pristup ima za cilj otkriti nove molekularne posrednike koštane resorpcije u upalnim artritisima, na razini specifičnoj za staničnu lozu. Predloženo istraživanje otvorit će nove mogućnosti za sprječavanje, ublažavanje i liječenje koštane resorpcije u upalnim zbivanjima.]]></summary_hr><summary_en><![CDATA[The inflammatory arthritides are chronic joint diseases, and a major health problem because of progressive disability. The most common form is rheumatoid arthritis (RA) characterized by bone and cartilage damage leading to deformity and permanent disability. Arthritis is also a common in systemic lupus erythematosus (SLE), mostly as a non-erosive form.In RA, inflammatory and immune cells create a microenvironment that favors osteoresorption by increasing osteoclast, and suppressing osteoblast differentiation and activity. Current treatment options such as biological therapeutics may modify the course of disease, but are not able to reverse osteoresorption.The Fas/Fas ligand system is important regulator of immune system homeostasis, and there is accumulating evidence for the role of this system in the regulation of bone homeostasis. Inactivation of Fas has a bone-sparing effect, preventing bone loss upon estrogen withdrawal, as well as in inflammatory arthritides, but the exact lineages and signaling pathways mediating this effect are not defined. Using the murine model of antigen-induced arthritis (AIA) in mice deficient for Fas, and synovial fluid samples from patients with RA and SLE, we aim to identify cell populations responsible for inhibition of osteoresorption, as well as functional alterations in these populations by analysing their gene expression profiles. In addition, we expect to confirm the role of identified genes/molecules by their inactivation in vivo in the murine model of AIA, and the role of a lineage using conditional lineage-specific models of Fas-inactivation. The analysis of human samples will allow for the translation to the clinical setting. Our approach aims to identify novel cellular/molecular drivers of bone resorption in arthritis, on a lineage-specific level. Proposed studies will provide new targets for preventing, reducing, and potentially reversing the osteoresorptive process which is a consequence of inflammatory events.]]></summary_en></project><project>
<id>3797</id><title_hr><![CDATA[Fiziološki i stereokemijski važni kompleksi bakra(II) s aminokiselinama: molekulsko modeliranje kombinirano s eksperimentalnim istraživanjima]]></title_hr><title_en><![CDATA[]]></title_en><user_id>11255</user_id><user_firstLast_name>Jasmina Sabolović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-4185</code><acronim><![CDATA[CopperAminoAcidates]]></acronim><duration>02.12.2016 - 20.05.2024</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut za medicinska istraživanja i medicinu rada]]></institution_hr><institution_en><![CDATA[Institute for Medical Research and Occupational Health]]></institution_en><team_members_id>21234</team_members_id><team_members_names><![CDATA[ Doktorand: Jelena Budimčić ]]></team_members_names><keywords_hr><![CDATA[bakar, aminokiseline, molekulsko modeliranje, DFT, MM, MD, rendgenska strukturna analiza, NMR čvrstog stanja, cis-trans izomerija, fiziološki spojevi]]></keywords_hr><keywords_en><![CDATA[copper, amino acids, molecular modelling, DFT, MM, MD, X-ray structure analysis, solid-state NMR, cis-trans isomerism, physiological compounds]]></keywords_en><summary_hr><![CDATA[Strukturna istraživanja kompleksa bis(amino acidato)bakra(II), Cu(aa)2, intenzivnije započeta prije oko 45 godina još traju jer su motivirana činjenicama da su to (1) biološki važni spojevi budući da sudjeluju u skladištenju i prijenosu bakra do mjesta u organizmu gdje u optimalnim koncentracijama taj esencijalan element ima važne fiziološke uloge, (2) modelni spojevi za vezivna mjesta za bakar u metaloproteinima, (3) stereokemijski zanimljivi spojevi. Unatoč intenzivnim eksperimentalnim istraživanjima fizioloških Cu(aa)2 posljednjih 40 godina, njihova kompletna geometrija u otopinama uglavnom je nepoznata. Naše je istraživanje bis(L-histidinato)bakra(II) primjenom teorije funkcionala gustoće (Density Functional Theory, DFT) prvo razjasnilo strukturu tog fiziološkog spoja u vodenoj otopini pri fiziološkim uvjetima (Eur J Inorg Chem 2014: 198). Nastavljajući se na naša prethodna istraživanja, glavni je cilj projekta dobiti nove rezultate o fizikalno-kemijskim svojstvima (strukture, energije, vibracije, cis-trans izomerija, konformacijske promjene) u vakuumu, vodenoj otopini i kristalnom okruženju izabranih Cu(aa)2 zbog njihove biološke važnosti i stereokemijske raznolikosti primjenom metoda molekulskog modeliranja (DFT, molekulska mehanika, molekulska dinamika) i eksperimentalnih metoda (rendgenska strukturna analiza, spektroskopija NMR čvrstog stanja). Očekujemo da ćemo kombiniranjem tim metoda pridonijeti rješavanju još uvijek neriješenih pitanja (1) točne geometrije u otopini i čvrstom stanju, (2) procesa na molekulskoj razini. Budući da je interes za istraživanje bakrovih kompleksa kao antiproliferacijskih spojeva znatno porastao u posljednjih nekoliko godina, a detaljna fizikalno-kemijska karakterizacija je prvi nužan korak u istraživanju, realno se očekuje da će novi rezultati pridonijeti otkrivanju novih lijekova. Rezultati istraživanja će značajno unaprijediti znanstvene spoznaje i primjene u bioanorganskoj kemiji, biofizici, biologiji i medicini.]]></summary_hr><summary_en><![CDATA[The structural studies of bis(amino acidato)copper(II) complexes, Cu(aa)2, which started intensively in the 1960s and continue up to date, have been motivated by the facts that these complexes are (1) biologically important as a part of the accessible physiological pool for transport and storage of an essential element copper, (2) appropriate models for copper-binding sites in metalloproteins, (3) sterochemically interesting compounds. Despite intensive experimental studies of physiological Cu(aa)2 during the last 40 years, their exact structures in solutions generally remain unresolved. Our density functional theory (DFT) study of bis(L-histidinato)copper(II) (Eur J Inorg Chem 2014: 198) is the first that clarified the structure of that physiological compound in aqueous solution at physiological conditions. Based on our previous studies, the main goal of the project is to obtain new results on the physico-chemical properties (structure, energy, vibrations, cis-trans isomerism, conformational changes) in different surroundings (vacuum, aqueous solution, solid state) of selected Cu(aa)2 because of their biological importance and stereochemical diversity by using the molecular modelling (DFT, molecular mechanics, molecular dynamics) and experimental (X-ray diffraction, solid-state NMR) methods. By combining these methods we expect to contribute to solving yet unresolved issues of (1) the exact geometries in solution and solid state, (2) the processes occurring at the molecular level. The new results will contribute to understanding the data required in the discovery of new potential drugs since the detailed physico-chemical characterisation is a necessary first step in the drug development. It is worth mentioning that the interest in copper coordination complex research as antiproliferative agents has markedly increased in the last few years. We expect our results to have an impact on applications in bioinorganic chemistry, biophysics, biology, and medicine. ]]></summary_en></project><project>
<id>3798</id><title_hr><![CDATA[Razvoj supramolekulskih receptora kationa i aniona]]></title_hr><title_en><![CDATA[]]></title_en><user_id>7690</user_id><user_firstLast_name>Vladislav Tomišić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-6341</code><acronim><![CDATA[SupraCAR]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>22634</team_members_id><team_members_names><![CDATA[ Doktorand: Katarina Leko ]]></team_members_names><keywords_hr><![CDATA[receptori iona, kaliksareni, dehidracetna kiselina, kompleksiranje, solvatacija, vodikove veze, termodinamika  ]]></keywords_hr><keywords_en><![CDATA[ion receptors, calixarenes, dehydroacetic acid, complexation, solvation, hydrogen bonding, thermodynamics]]></keywords_en><summary_hr><![CDATA[Razvoj efikasnih i selektivnih receptora nabijenih kemijskih vrsta od velike je važnosti. U okviru ovog projekta dizajnirat će se, sintezirati i karakterizirati brojni takvi spojevi. Priredit će se niz novih derivata kaliksarena koji bi trebali efikasno i selektivno vezati razne katione i anione. Neki od tih spojeva predviđeni su da mogu poslužiti u analitičke svrhe, posebice kao ekstraktanti, drugi će sadržavati fluorescentne ili aminokiselinske podjedinice, dok će prilikom dizajna jednog dijela kaliksarenskih derivata posebna pažnja biti usmjerena poboljšanju njihove topljivosti u vodi. Također će se prirediti niz derivata dehidracetne kiseline kao anionskih receptora koji će sadržavati aminske, amidne, ureidne i tioureidne podjedinice. Kompleksacijski afiniteti svih navedenih spojeva prema raznim supstratima proučit će se sveobuhvatnim pristupom koji uključuje termodinamička, komputacijska i strukturna istraživanja. Koristit će se brojne spektroskopske i elektrokemijske metode, kao i (mikro)kalorimetrija, što će omogućiti određivanje pouzdanih termodinamičkih podataka (konstante stabilnosti, standardne Gibbsove energije, entalpije i entropije reakcija kompleksiranja i otapanja). Bit će provedene i simulacije molekulske dinamike istraživanih sustava, što će pripomoći dizajnu novih spojeva te interpretaciji eksperimentalnih nalaza. Pored toga, uz rezultate postignute spektroskopijom NMR te rentgenskom strukturnom analizom, te će simulacije pružiti uvid u strukturne karakteristike receptora i njihovih kompleksa. Posebna će pažnja biti posvećena utjecaju vodikovih veza i solvatacije na ravnoteže reakcija kompleksiranja. U tu svrhu koristit će se brojna otapala različitih solvatacijskih svojstava i afiniteta za stvaranje vodikovih veza. Očekuje se da će dobivene termodinamičke informacije omogućiti stjecanje detaljnog uvid u reakcije kompleksiranja, kao i utjecaj otapala na njihov ishod, što bi trebalo olakšati i ubrzati daljnji razvoj supramolekulskih receptora.]]></summary_hr><summary_en><![CDATA[The importance of development of efficient and selective receptors of charged species has been widely recognised. In the framework of this project, a variety of such compounds will be designed, synthesised, and characterised. A series of novel calixarene derivatives capable of strongly and selectively binding cations and anions will be prepared. Some of these compounds are aimed to be efficient liquid-liquid extraction agents whereas the others will be designed to be water-soluble or to bear fluorescent and amino-acid substituents. Another class of anion receptors which will be synthesised comprises amine, amide, urea, and thiourea derivatives of dehydroacetic acid. The complexation abilities of all the compounds mentioned towards various substrates will be explored by using an integrated approach which includes thermodynamic, computational, and structural studies. A number of spectroscopic and electrochemical methods as well as (micro)calorimetry will be employed. That should yield detailed and reliable thermodynamic data (stability constants, reaction and solution Gibbs energies, enthalpies and entropies). In order to facilitate the design of the targeted molecules and to assist the interpretation of the experimental results, the molecular dynamics simulations of the systems studied will be carried out. This will, together with the results of NMR studies and that of solid-state X-ray diffraction investigations, also ensure information about structural characteristics of the receptors and their complexes. Particular attention will be focused on the hydrogen-bonding and solvation effects on the equilibria of binding reactions. For that reason, many solvents with different solvation and hydrogen-bonding affinities will be used. The obtained thermodynamic information is expected to provide a detailed insight into the complexation processes and the influence of medium on the reactions studied, which will allow further development of efficient supramolecular receptors.]]></summary_en></project><project>
<id>3800</id><title_hr><![CDATA[Otkrivanje novih proteinskih interakcija kao podloga za nove pristupe liječenju melanoma čovjeka]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1107</user_id><user_firstLast_name>Maja Herak Bosnar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-9044</code><acronim><![CDATA[ProNetMel]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>22818</team_members_id><team_members_names><![CDATA[ Doktorand: Martina Radić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[melanoma, protein interactions, p53, p73, nm23, Gli]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Metastatic melanoma represents a major clinical problem due to rising incidence and resistance to available therapies. Therefore, there is a necessity for developing novel molecular approaches to treat this disease. Unlike other tumors, in melanoma p53 is relatively rarely mutated. However, overexpressed p53 fails to function as a tumor suppressor and tumor cells continue to proliferate and spread. This suggests that regulation of p53 activity depends on the interplay between p53 and its binding partners. Based on current state of knowledge, we hypothesize that p53 function in malignant melanoma might be altered through the interactions with p53 small molecular weight and p73 isoforms, nm23/NDPK and Gli families of proteins. Thus we will search for p53 protein binding partners in melanoma. The interactions identified by mass spectrometry will be further confirmed using microarray-based approaches and co-immunoprecipitation techniques. Furthermore, the expression profile of genes/proteins of interest in panel of melanoma cell lines and melanoma tissue samples will be investigated. The potential impact of the identified p53 interacting partners on its transcriptional activity and the stimulation of apoptosis will be determined. The depletion of partners using siRNA technology would confirm the involvement of selected proteins on p53 activity. The subcellular localization of the proteins in complex will be revealed by advanced fluorescent microscopy methods on state-of-the-art instrumentation what would give us the insight on dynamics of their interactions. The proposed research could provide a possible explanation why p53 function in melanoma is abrogated. The aim of this project is to determine the complexity of p53 interactions and their role in the onset and progression of human melanoma and offer new, innovative solutions in diagnosis, prognosis and therapy.]]></summary_en></project><project>
<id>3801</id><title_hr><![CDATA[Rana faza razvoja kompleksa za stvaranje viriona tijekom citomegalovirusne infekcije]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6604</user_id><user_firstLast_name>Pero Lučin</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-2825</code><acronim><![CDATA[]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Medicine]]></institution_en><team_members_id>21237</team_members_id><team_members_names><![CDATA[ Doktorand: Marina Marcelic ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>3802</id><title_hr><![CDATA[MORUS - Unmanned system for maritime security and environmental monitoring]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5244</user_id><user_firstLast_name>Stjepan Bogdan</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-2875</code><acronim><![CDATA[]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>22725</team_members_id><team_members_names><![CDATA[ Doktorand: Marko Car Car ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>3803</id><title_hr><![CDATA[Programski sustavi u evoluciji: analiza i inovativni pristupi pametnom upravljanju]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1409</user_id><user_firstLast_name>Tihana Galinac Grbac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-2580</code><acronim><![CDATA[EVOSOFT]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Tehnički fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Engineering]]></institution_en><team_members_id>22612</team_members_id><team_members_names><![CDATA[ Doktorand: Ana Vranković ]]></team_members_names><keywords_hr><![CDATA[evolucija, kompleksni softverski sustavi, pametno upravljanje, distribucije neispravnosti, struktura]]></keywords_hr><keywords_en><![CDATA[evolution, complex software system, smart management, fault distributions, structure]]></keywords_en><summary_hr><![CDATA[Kompleksni programski sustavi koji se evolucijski razvijaju (EVOSOFT) postali su središnji sve većeg broja aplikacija, proizvoda i usluga, a koji su potpora svakodnevnim ljudskim aktivnostima iz svih gospodarskih sektora. Često su to distribuirani sustavi , heterogeni , decentralizirani i međusobno zavisni, koji rade u dinamičnim i nepredvidljivim uvjetima, pa su njihova dostupnost i pouzdanost postale ključna svojstva potrebna za njihov rad i budući razvoj. Novoi još neistraženo područje istraživanja a koje se obrađuje u ovom projektu je razumjeti kako apstraktne programske strukture i lokalna obilježja sustava utječu na distribuciju neispravnosti, a čime se utječe na kritična svojstva sustava, među kojima je dostupnost i pouzdanost te razvijati inovativne pristupe za pametno upravljanje njihovim izvođenjem i evolucijom. Potrebno je za naglasiti da se ovdje suočavamo s potpuno novim pojavama, sličnim ljudskoj evoluciji, ali koje su proizvedene ljudskim intelektom. Temelji i teorije iz drugih disciplina kojima je cilj razumjeti ponašanje kompleksnih sustava, evolucije te ljudsko razmišljanje mogle bi ovdje biti primijenjive. Novi rezultati otvoriti će nove mogućnosti u mnogim znanstvenim područjima, osobito u teoriji kompleksnih sustava i njenih primjena, te tako međudjelovati sa širokim spektrom znanosti, od prirodnih znanosti kao što su to biomedicina pa sve do društvenih znanosti . Industrijsko iskustvo prikupljeno iz empirijskog pristupa programskom inženjerstvu je iznimno važno za daljnji razvoj discipline programskog inženjerstva. Nove teorije ne mogu biti djelotvorne i primjenjive u industriji, bez temeljnog razumijevanja EVOSOFT ponašanja . Glavni cilj ovog projekta je da će ispuniti taj jaz između empirijskih dokaza i teoretskih modela . Kako bi ostvarili taj cilj kombiniramo empirijska i teoretska znanja tako što ćemo:• ponoviti studije i potvrditi empirijske principe i metode i na kojima želimo graditi nove teorije ,• definirati strukturalne ovisnosti za primjenu empirijskih principa, metoda ,• definirati formalne modele i inovativne načine pametnog upravljanja .]]></summary_hr><summary_en><![CDATA[Evolving complex software systems (EVOSOFT) have become a central part of a rapidly growing range of applications, products and services supporting daily human activities from all economic sectors. As they are often distributed, heterogeneous, decentralized and inter-dependent, and operating in dynamic and unpredictable environments, availability and reliability become key properties for its operation and future evolution. The novel and still unexplored area of research addressed in this project is to understand how abstract software structures and local system properties influence fault distributions, thus affecting mission critical system properties, among which availability and reliability and to develop innovative approaches for smart management of their operation and evolution. We are facing with completely new phenomena, similar to human evolution, but produced by human intellect. Foundations and theories from other disciplines aiming to understand complex system behavior, evolution and human reasoning could be applied. New findings would open new opportunities in many scientific fields, especially in complex systems theory and its applications, thus interacting with a wide spectrum of sciences, from natural sciences such as biomedicine to social sciences. Industrial experience gathered by systematic Empirical Software Engineering approach is extremely important for further evolution of software engineering discipline. New theories cannot provide effective means for industry without fundamental understanding of EVOSOFT behavior. The main aim of this project is to fulfill this gap between empirical evidence and theoretical models. In that aim we combined empirical and theoretical skills aiming to: • replicate studies and confirm empirical principles and methods and define a solid base to ground new theories, • define structural dependencies for applicability of empirical principles, methods, • define formal models and innovative approaches for smart management.]]></summary_en></project><project>
<id>3805</id><title_hr><![CDATA[Algoritmi za mjerenje sustavskog rizika]]></title_hr><title_en><![CDATA[]]></title_en><user_id>13406</user_id><user_firstLast_name>Zvonko Kostanjčar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-3270</code><acronim><![CDATA[ASYRMEA]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>21046</team_members_id><team_members_names><![CDATA[ Doktorand: Stjepan Begušić ]]></team_members_names><keywords_hr><![CDATA[sustavski rizik, kompleksni sustavi, mrežna dinamika, rijetkost, vremenski diskretni signali]]></keywords_hr><keywords_en><![CDATA[systemic risk, complex systems, network dynamics, sparsity, discrete time signals]]></keywords_en><summary_hr><![CDATA[Razmatramo kompleksni sustav, poput nuklearne elektrane, koji je građen od velikog broja podsustava s određenom vjerojatnošću kvara koje nisu nezavisne. Zanima nas vjerojatnost kvara cijelog sustava koji se događa kad neki podskup podsustava zakaže, tj. zanima nas sustavski rizik. Kako možemo modelirati takvu situaciju i procijeniti sustavski rizik? Na žalost, to je vrlo teško i nismo dobri u tome, pa tako npr. red veličine vjerojatnosti kvara neke nuklearne elektrane još uvijek nije poznata. Čini se da je to zato što je većina poznatih korelacijskih struktura u vjerojatnosti nisko dimenzionalna ili čak jednodimenzionalna. Međutim, u kompleksnim sustavima su korelacijske strukture visoko dimenzionalne i obično ne vrijedi pretpostavka nezavisnosti. Cilj ovog istraživačkog projekta je pronaći učinkovite algoritme za mjerenje sustavskog rizika definiranjem novih klasa modela višedimenzionalnih korelacijskih struktura u velikom skupu slučajnih varijabli. Definirani modeli moraju biti računalno izvedivi i dovoljno jednostavni da im se parametri mogu estimirati iz podataka u različitim primjenama višedimenzionalne analize podataka.U ovom projektu ćemo nastaviti koristiti metode matematičkog i računalnog modeliranja, konkretno: kompleksnih mreža, rijetkih estimacija i koncentracije mjere. Koristeći ovaj pristup smo već postigli vrlo važne rezultate, poput uvida u nastajanje zakona potencija i dvofaznog ponašanja u fluktuacijama financijskih tržišta. Također bismo s ovim pristupom željeli bolje razumjeti sustavski rizik i stabilnost kompleksnih sustava (npr. financijskog sustava). Potreba za znanstveno utemeljenom mjerom sustavskog rizika nije samo akademska zato što se diljem svijeta pokušava smanjiti rizik i troškovi sustavskih kriza.]]></summary_hr><summary_en><![CDATA[Consider a complex system (such as a nuclear plant) that is made from many subsystems which themselves have certain probabilities of failure, and these probabilities are not independent. Suppose that we are interested in the probability of failure of the entire system, failure that occurs when certain subset of the subsystems fail, i.e. we are interested in the systemic risk. How do we model such a situation and estimate the systemic risk? Unfortunately, this is very difficult, and we are not very good at it, e.g. the order of magnitude of the probability of failure of a nuclear plant is still ungraspable. It seems that this is because most of the familiar correlation structures in probability are low-dimensional, or even one-dimensional. However, correlation structures in complex systems are high-dimensional and usual independence assumption is seriously violated. The goal of this research project is to find efficient algorithms for systemic risk measurement by defining a new class of models of high-dimensional correlation structures in a large collection of random variables. The defined models should be computationally tractable and simple enough so that one can bring them to data and use it for various applications in high-dimensional data analysis.In this project we will continue to use the methods of mathematical and computational modeling, specifically: complex networks, sparse estimation, and concentration of measure. With this approach, we have already obtained very important results, like an insight into the emergence of power-law and two-phase behavior in the financial market fluctuations. Also, with this approach we would like to better understand the basic mechanisms that underlie systemic risk and the stability of the complex systems (e.g. financial system). The need for scientific foundations for a systemic risk measure is more than an academic concern as different people around the world consider how to reduce the risks and costs of systemic crises.]]></summary_en></project><project>
<id>3807</id><title_hr><![CDATA[CRISPR Adaptation - the basis for prokaryotic adaptive immunity]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4503</user_id><user_firstLast_name>Ivana Ivančić Baće</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-6320</code><acronim><![CDATA[]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>22812</team_members_id><team_members_names><![CDATA[ Doktorand: Marin Radovčić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>3811</id><title_hr><![CDATA[Procesna i poslovna inteligencija za poslovnu izvrsnost ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1246</user_id><user_firstLast_name>Vesna Bosilj Vukšić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-9225</code><acronim><![CDATA[PROSPER]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Informacijske znanosti, </scie_field_hr><scie_field_en>Information sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Ekonomski fakultet u Zagrebu]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Economics and Business]]></institution_en><team_members_id>22659</team_members_id><team_members_names><![CDATA[ Doktorand: Ana-Marija Stjepić ]]></team_members_names><keywords_hr><![CDATA[procesna inteligencija, poslovna inteligencija, upravljanje poslovnim procesima, mjerenje i upravljanje performansama, rudarenje podataka, softver]]></keywords_hr><keywords_en><![CDATA[process intelligence, business intelligence, business process management, performance measurement and management, data mining, software]]></keywords_en><summary_hr><![CDATA[Svrha projekta PROSPER je istražiti primjenu procesne (PI) i poslovne inteligencije (BI) u poduzećima i njihov utjecaj na uspješnost poslovanja, s posebnim fokusom na korištenje modernih tehnologija (kao što su sustavi za upravljanje poslovnim procesima, rudarenje podataka, simulacijski softver) pri implementaciji ovih koncepata. Primijenit će se odgovarajući istraživački pristup. Koristiti će se statističke metode (kao što su modeli strukturnih jednadžbi - SEM) i metode kvalitativnog istraživanja (na primjer kvalitativno istraživanje kulturalnih razlika primjene procesne i poslovne inteligencije u u Hrvatskoj, Sloveniji, Austriji i Bosni i Hercegovini). Projekt je multidisciplinaran i više-razinski, a njegovi su ciljevi hijerarhijski strukturirani.Na najvišoj razini (L1) istražit će se primjena i zrelost procesne i poslovne inteligencije u  zemljama iz kojih dolaze suradnici na projektu. Provest će se empirijsko istraživanje, dobiveni rezultati analizirati će se kvantitativnim metodama (regresijska i faktorska analiza). Na drugoj razini (L2) istražit će se kritični faktori uspješnosti primjene koncepata procesne i poslovne inteligencije. U tu svrhu će se koristiti kvalitativne (studije slučaja, polu-strukturirani intervjui)  i kvantitativne metode (modeli strukturnih jednadžbi).  Rezultati istraživanja koristiti će se za razvoj modela za mjerenje procesnih performansi. Na trećoj razini (L3) testirati će se primjenjivost rezultata istraživanja iz prethodnih razina (L1 i L2), a u tu svrhu će se provesti kvalitativno istraživanje u poduzećima. Kroz studije slučaja testirati će primjena procesne i poslovne inteligencije i njihov utjecaj na uspješnost poslovanja.  Razviti će se modeli iz područja poslovne inteligencije za neke specifične poslovne slučajeve i djelatnosti. Primjena ovih modela omogućiti će uspješnije poslovanje. ]]></summary_hr><summary_en><![CDATA[The aim of the PROSPER project is to examine the adoption of the process intelligence (PI) and business intelligence (BI) in organizations, as well as to foresee their impact on business performance using cutting-edge technologies (e.g. business process management systems, data mining, simulation software) and research approach (e.g. cross-cultural research, structural equation modelling) with the assistance of multi-country (Croatia, Slovenia, Austria, Bosnia and Herzegovina) and interdisciplinary team of university researchers. The project is multidisciplinary and multi-levelled due to the hierarchical structure of its objectives.At the highest level (L1), the adoption and maturity of PI and BI will be explored in organizations in Croatia, Slovenia, Bosnia and Herzegovina and Austria. A quantitative empirical research results will be analysed using regression and factor analysis. At the middle level (L2), the impact of critical factors (e.g. organizational culture and structure) on PI and BI adoption will be analyzed. L2 research results will be explored using qualitative (e.g. case study, semi-structured interviews) and quantitative methods (e.g. structural equation modelling), the goal being development of the process performance measurement model. At the third level (L3), the practical applicability of the L1 and L2 research results will be tested and evaluated using specific business cases in PI and BI adoption for business performance. Models will be developed for the usage of BI in some specific business cases and industries, with the goal of increasing business performance.]]></summary_en></project><project>
<id>3812</id><title_hr><![CDATA[Vojnički život i slike ratnika u hrvatskom pograničju od 16. stoljeća do 1918.]]></title_hr><title_en><![CDATA[]]></title_en><user_id>265</user_id><user_firstLast_name>Alexander Buczynski</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-2397</code><acronim><![CDATA[MLWICB]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Povijest, </scie_field_hr><scie_field_en>History, </scie_field_en><institution_hr><![CDATA[Hrvatski institut za povijest]]></institution_hr><institution_en><![CDATA[Croatian Institute of History]]></institution_en><team_members_id>3212</team_members_id><team_members_names><![CDATA[ Doktorand: Juraj Balić ]]></team_members_names><keywords_hr><![CDATA[kulturna povijest, povijesna demografija, Habsburška Monarhija, Venecija, Vojna krajina, Dalmacija, gerila, vojni popisi, vojna revolucija, novine]]></keywords_hr><keywords_en><![CDATA[cultural history, historical demography, Habsburg Monarchy, Venice, Military Frontier, Dalmatia, guerilla, muster rolls, military revolution, news]]></keywords_en><summary_hr><![CDATA[Prinosi vojnika s hrvatskog pograničja u vojnim postrojbama Habsburške Monarhije, Mletačke Republike, Osmanskog Carstva i Francuskog Carstva neprijeporna su činjenica. Zahvaljujući opsežnom i vremenski kontinuirano sačuvanom arhivskom gradivu koje se odnosi na razdoblje ranog novog vijeka i dugog 19. stoljeća, ta se problematika može sustavno istraživati primjenom multidisciplinarnih metoda. Cilj ovog projekta je istražiti demografske, društveno-ekonomske i političke prilike u hrvatskom pograničju, kao i utvrditi uzročno-posljedične veze između navedenih prilika (razvojnih sastavnica) koje su činile svakodnevnicu hrvatskih vojnika i kreirale njihov identitet. Istraživanje će se usredotočiti na Ličku i Otočku pukovniju u Vojnoj krajini, Zadar i Kotor kao središnja mletačka vojna uporišta na istočnoj obali Jadrana, Dubrovačku Republiku te Dalmaciju u vrijeme austrijske i francuske uprave. Rekonstrukcija svakodnevice i identiteta pripadnika vojničkog društva objedinit će: 1. demografska kretanja (natalitet, fertilitet i mortalitet), migracije, društveno-ekonomski kontekst (dobna, spolna i profesionalna struktura); 2. vojni i ratni kontekst (vojna organizacija i obuka, “mali rat“ – “partizanski način ratovanja“ – umijeće ratovanja, imidž i samosvijest hrvatskih vojnika); 3. geo-politički kontekst (upravno-pravna podjela, tranzicije vlasti). Jedan od temeljnih ciljeva istraživačkog tima jest znanstveno obraditi te kroz bazu podataka prikazati što veći broj vojnih popisa, matičnih knjiga, popisa stanovništva, popisa stradalnika, zemljišnih knjiga koji se odnose na Ličku i Otočku pukovniju, Zadar, Dubrovačku Republiku i Kotor. Rečeni bi izvori, odnosno podatci, bili kreirani i dostupni u on-line bazi otvorenog pristupa te integrirani u svjetske mreže sličnih baza kao što su EHPS-Net i MOSAIC i kao takvi služili bi multidisciplinarnoj svrsi.]]></summary_hr><summary_en><![CDATA[The contribution of soldiers from Croatian borderlands to the armed forces of the Habsburg Monarchy, Republic of Venice, Ottoman Empire and French Empire is beyond dispute. Thanks to comprehensive and continuous archive records relevant to the early modern period and long nineteenth century, this issue can be thoroughly researched on a multidisciplinary level. This project aims to explore demographic, socio-economic and political circumstances in Croatian borderlands, and to examine cause and effect relationships between these circumstances (developmental components) that made up the everyday life of Croatian soldiers, their families and households, and formed their identity. Research will focus on the Otočac and Lika Regiments of the Military Frontier, Zadar and Kotor as central strongholds of the Republic of Venice on the East Adriatic, the Republic of Dubrovnik and Dalmatia during the French and Austrian administration. The reconstruction of everyday life and the identity of the martial people that inhabited these borderlands will include: 1. demographic data (birth rates, fertility and mortality), migrations and the socio-economic context (age, gender and professional structure); 2. the military and war context (military organization and training, la petite guerre - partisan warfare - and the art of war, images and self-awareness of Croatian soldiers); 3. the geo-political context (administrative and legal organization, government transitions). One of the main objectives of the research team is to process a large quantity of muster rolls and other military lists, birth, marriage and death registers, casualty lists, land registers etc, covering the Otočac and Lika Regiments, Zadar, Dalmatia, Republic of Dubrovnik and Kotor in order to create an open access database that can be integrated within networks as EHPS-Net and MOSAIC and will thus serve a multidisciplinary purpose.]]></summary_en></project><project>
<id>3813</id><title_hr><![CDATA[Razjašnjavanje sortne tipičnosti vina i maslinovih ulja od hrvatskih domaćih sorti]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4924</user_id><user_firstLast_name>Igor Lukić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-2570</code><acronim><![CDATA[TYPICRO]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Prehrambena tehnologija, </scie_field_hr><scie_field_en>Food technology, </scie_field_en><institution_hr><![CDATA[Institut za poljoprivredu i turizam]]></institution_hr><institution_en><![CDATA[Institute of Agriculture and Tourism in Poreč]]></institution_en><team_members_id>21020</team_members_id><team_members_names><![CDATA[ Doktorand: Ivana Horvat ]]></team_members_names><keywords_hr><![CDATA[sortna tipičnost, vino, maslinovo ulje, domaće sorte, Hrvatska, hlapljive arome, fenoli, senzorna analiza, kemometrija, tehnologija]]></keywords_hr><keywords_en><![CDATA[varietal typicity, wine, olive oil, native varieties, Croatia, volatile aroma, phenols, sensory evaluation, chemometrics, technology]]></keywords_en><summary_hr><![CDATA[Projekt TYPICRO nastoji razjasniti sortnu tipičnost vina i maslinovih ulja od hrvatskih domaćih sorti. Odabrati će se tipični uzorci te će se definirati tipične senzorne karakteristike i deskriptori od strane profesionalnih certificiranih senzornih ocjenjivača. Izraditi će se novi obrazac za kvantitativno deskriptivno senzorno ocjenjivanje tipičnosti. Uzorci tipičnih vina i maslinovih ulja od domaćih i introduciranih sorti biti će podvrgnuti detaljnom kemijskom profiliranju i kvantifikaciji pomoću mikroekstrakcije na čvrstoj fazi uz plinsku kromatografiju-spektrometriju masa (HS-SPME-GC-MS) za hlapljive spojeve arome, te tekućinske kromatografije visokog razlučivanja s detekcijom nizom dioda (HPLC-DAD) za fenole. Uzorci će se senzorno ocijeniti kvantitativnom deskriptivnom analizom. Rezultati će biti obrađeni kemometrijskim metodama. Prototipski proizvodi domaćih sorti biti će podvrgnuti dubinskoj metabolomskoj i olfaktometrijskoj (AEDA s GC-O) analizi u svrhu identifikacije novih spojeva, te određivanja hijerarhije hlapljivih sastojaka odnosno njihovog relativnog doprinosa tipičnoj aromi. Očekivani rezultati uključuju određivanje tipičnog kemijskog sastava i senzornih svojstava sortnih vina i maslinovih ulja od domaćih i introduciranih sorti, utvrđivanje fizikalno-kemijske osnove i nositelja senzorne tipičnosti, utvrđivanje biljega sortnog podrijetla za diferencijaciju između tipičnih proizvoda od domaćih i introduciranih sorti, određivanje nepromjenjivih osobina i pokazatelja sortnog podrijetla unatoč unutarsortnoj varijabilnosti, te određivanje unutarsortnih razlika. Kroz niz poljskih i tehnoloških pokusa identificirati će se čimbenici koji doprinose isticanju i očuvanju tipičnosti. Biti će ispitan stupanj prepoznatljivosti tipičnih domaćih vina i ulja među stručnjacima, znalcima i proizvođačima. Rezultati ovog projekta predstaviti će se kroz niz javnih predavanja, konferencija i radionica, te će biti objavljeni u međunarodno relevantnim znanstvenim časopisima.]]></summary_hr><summary_en><![CDATA[TYPICRO project aims to unravel the varietal typicity of wines and olive oils from Croatian native varieties. Typical wines and olive oils will be selected and their typical sensory characteristics and descriptors will be defined by professional certified tasters. A novel quantitative descriptive sensory evaluation form for the assessment of typicity will be created. Typical samples from native and introduced varieties will be subjected to chemical profiling and quantification by headspace solid-phase microextraction with gas chromatography-mass spectrometry (HS-SPME-GC-MS) for volatile aromas, and high performance liquid chromatography with diode-array detection (HPLC-DAD) for phenolics. Quantitative descriptive sensory evaluation will be performed. The results will be processed by chemometrics. The prototypical monovarietal products will be subjected to in-depth metabolomic and olfactometric analysis to identify previously unidentified compounds, and to determine the hierarchy of volatiles and their relative contribution to typical aroma. Expected results include: determination of typical chemical composition and sensory characteristics of wines and olive oils from native and introduced varieties in Croatia, determination of the physico-chemical basis and drivers of sensory typicity, determination of markers of varietal origin able to discriminate between typical products from native and introduced varieties, determination of unchanging characteristics and indicators that remain determinants of varietal origin despite intra-varietal variability, determination of intra-varietal differences. Factors that highlight and preserve varietal typicity will be identified through a set of field and technological experiments. The recognisability of typical products will be tested in blind-tasting trials. The outcomes of the project will be disseminated through public presentations, conferences and a workshop, and published in internationally relevant scientific journals.]]></summary_en></project><project>
<id>3814</id><title_hr><![CDATA[Strengthening adaptive immunity via innate immunity: enhancing the CD8 T cell response by using the NKG2D ligand expressed in a herpesvirus vector]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4652</user_id><user_firstLast_name>Berislav Lisnić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-9782</code><acronim><![CDATA[]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Medicine]]></institution_en><team_members_id>22696</team_members_id><team_members_names><![CDATA[ Doktorand: Tina Jenuš ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>3815</id><title_hr><![CDATA[Istraživanje razvoja, diferencijacije i evolucije životinja kroz genomiku bazalnih metazoa ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1187</user_id><user_firstLast_name>Kristian Vlahoviček</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-6331</code><acronim><![CDATA[BAMGEN]]></acronim><duration>01.11.2016 - 31.12.2021</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>25056</team_members_id><team_members_names><![CDATA[ Doktorand: Maja Kuzman ]]></team_members_names><keywords_hr><![CDATA[regulacija gena, genomika, transkriptomika, spužve, genomika raka]]></keywords_hr><keywords_en><![CDATA[gene regulation, genomics, transcriptomics, sponges, cancer genomics]]></keywords_en><summary_hr><![CDATA[Projekti velikih razmjera koji uključuju metode -omike priskrbili su veliku količinu znanja o molekularnim mehanizmima u stanicama i tkivima ljudi i modelnih organizama, te pružili mnoštvo informacija o raznolikosti staničnih procesa, poglavito genske regulacije. Ti su projekti ujedno razotkrili neizmjernu kompleksnost životinjske stanice, potencijal za diferencijaciju u stanice različitih tkiva, gubitak kontrole pri nastajanju raka, te time potakli niz dubljih pitanja na različitim područjima znanosti o životu: Kako funkcionira diferencijacija u specifične stanice tkiva? Koliko su mehanizmi genske regulacije očuvani kroz životinjsko carstvo? Odakle potječe kompleksnost procesa diferencijacije? I, konačno, koje je porijeklo višestaničnosti?  Bazalne životinje (Metazoa), ključne su za odgovore na ova pitanja: mi na njih namjeravamo odgovoriti proučavanjem ne-modelnih organizama na samom dnu životinjskog evolucijskog stabla - najjednostavnijim višestaničnim životinjama - spužvama (Porifera). Spužve su najstarije danas živuće životinje koje su se vjerojatno najranije odvojile na razvojnom stablu životinja, te posjeduju neka izvanredna svojstva koja ih čine idealnim modelom za istraživanja regulacije gena uključenih u razvoj: u bliskoj su simbozi s jednostaničnim prokariotima, sadrže mali broj osnovnih tipova stanica, nemaju pravih tkiva, organa ni zametnih listića, a istovremeno posjeduju mnoge gene uključene u rani razvoj i povezane s nastankom raka, kao i totipotentne stanice. Metodama komparativne genomike i transkriptomike, htjeli bismo istražiti procese unutar simbioze, kao i procese razvoja i diferencijacije stanica za koje vjerujemo da su naslijedile sve višestanične životinje.  Pomoću čvrste mreže suradnika, stručnjaka u području biologije Metazoa s iskustvom u  metodama genomike i računalne biologije kompleksnih sustava, te preliminarnim setom zanimljivih rezultata, namjeravamo odgovoriti na prethodno postavljena pitanja i interdisciplinarnim pristupom razjasniti neka od ključnih otvorenih pitanja na području genomike i evolucije čitavog životinjskog carstva.]]></summary_hr><summary_en><![CDATA[Large scale –omics projects have provided valuable knowledge on the molecular mechanisms occurring in cells and tissues of human and other related model organisms, delivering a wealth of information on the diversity of cellular processes, and in particular gene regulation. Yet, these projects have also uncovered the immense complexity of the animal cell, its potential to differentiate into various tissues, or spiral out of control by forming cancer, opening up even more profound questions on diverse fronts of the life sciences: How does tissue-specific cell differentiation work? How conserved are gene regulation mechanisms throughout animal kingdom? Where does complexity of differentiation originate from? And, finally, what is the origin of multicellularity?Basal metazoans hold key answers to these questions: we propose to tackle them by investigating the non-model organisms at the very base of the animal evolutionary tree – the simplest multicellular animals – sponges (Porifera). Sponges, are probably the earliest branching and the oldest extant animals. They hold remarkable properties that make them an excellent subject for studying developmental gene regulation: a handful of major cell types, no true tissues and organs, and no germ layers, but at the same time they are rich in early developmental genes associated to cancer and possessing totipotent cells. With the aid of comparative genomics and transcriptomics, we wish to explore developmental and cell differentiation processes that we believe are ancestral to all multicellular animals.With a strong collaboration network, expert base in metazoan biology, expertise in genomics and computational biology of complex systems, and a preliminary set of interesting results, we propose to answer the above questions through a truly interdisciplinary approach and elucidate some of the crucial open questions in genomics and evolution of the entire animal kingdom. ]]></summary_en></project><project>
<id>3818</id><title_hr><![CDATA[Molekularni mehanizmi ugradnje homolognih i heterolognih proteina u staničnoj stijenci kvasca i njihova primjena u biotehnologiji]]></title_hr><title_en><![CDATA[]]></title_en><user_id>359</user_id><user_firstLast_name>Vladimir Mrša</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-2173</code><acronim><![CDATA[CEWAPROT]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Biotehnologija, </scie_field_hr><scie_field_en>Biotechnology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Food Technology and Biotechnology]]></institution_en><team_members_id>25089</team_members_id><team_members_names><![CDATA[ Doktorand: Mateja Lozančić ]]></team_members_names><keywords_hr><![CDATA[stančna stijenka kvasca, proteini stanične stijenke, lokalizacija proteina, heterologna ekspresija, izlaganje na staničnoj površini, genetička imobili]]></keywords_hr><keywords_en><![CDATA[yeast cell wall, cell wall proteins, protein localization, heterologous expression, surface display, genetic immobilization]]></keywords_en><summary_hr><![CDATA[Stanična stijenka kvasca sastoji se od unutrašnjeg sloja glukana na koji su s vanjske strane vezani manoproteini. Velika je raznolikost među proteinima stijenke, ne samo u strukturama i aktivnostima, nego i u načinu na koji su ugrađeni u stijenku. Neki od njih vezani su nekovalentno, neki kovalentno putem esterske veze nestabilne u lužinama, a neki također kovalentno, ali putem GPI-sidra i beta-1,6-glukana. Za najzastupljeniji nekovalentno vezani protein, Scw4p, nađeno je da je na glukan djelomično vezan i kovalentno, još nepoznatom vrste veze. Jedan od ciljeva ovog projekta je objasniti molekularnu prirodu te veze. Osim toga, za nekoliko proteina stijenke, uključujući i Scw4p nađeno je da su proteolitički procesirani. Drugi cilj ovog projekta bio bi ispitati koje proteaze cijepaju Scw4p i koji je fiziološki značaj te modifikacije.Poznavanje mehanizama ugradnje proteina u stijenku kvasca upotrijebit će se za ugradnju i izlaganje na površini heterolognih proteina eksprimiranih u kvascu. Pripremit će se novi plazmidi u tu svrhu, za ekspresiju i ugradnju proteina u stijenku kvasaca S. cerevisiae i P. pastoris. Analizirat će se i stanične stijenke više drugih kvasaca izoliranih iz različitih habitata kako bi se ispitala mogućnost da oni budu novi domaćini za izlaganje proteina.Kako već postojeći, tako i novoistraženi genetički sustavi upotrijebit će se za izlaganje na površini šest enzima biokemijskog puta za degradaciju S-triazina iz bakterije Pseudomonas ADP. Istražit će se primjena dobivenih kvaščevih sojeva za degradaciju ovog široko korištenog herbicida.Druga potencijalna primjena ove metodologije obuhvatit će izlaganje nekoliko ksiloza reduktaza iz različitih kvasaca i primjenu dobivenih sojeva u proizvodnji ksilitola iz ksiloze uz odgovarajuću elektrokemijsku regeneraciju potrebnog NAD(P)H. Ispitat će se i potencijal te metode za primjenu u biosenzorima.]]></summary_hr><summary_en><![CDATA[Yeast cell wall consists of an inner layer of beta-1,3-glucan to which mannoproteins are attached. There is a pronounced variability among yeast cell wall proteins not only in their structures and activities, but also in the way they are incorporated into the wall. Some of them are attached non-covalently, some are linked covalently through an alkali labile ester linkage, and some are attached through GPI anchors and beta-1,6-glucan. The most abundant non-covalently attached protein Scw4p was found to be partly also covalently attached to glucan by a so far unknown linkage. One of the goals of this project is to explain the molecular nature of this linkage. Several cell wall proteins including Scw4p were found to be proteolytically processed. The second goal of the proposed project is to investigate which protease cleaves Scw4p and what is the physiological significance of this modification.Our comprehension of molecular mechanisms for incorporation of proteins in the yeast cell wall can be used for surface display of heterologous proteins expressed in yeasts. New plasmids will be created for this purpose for expression and wall incorporation of proteins in S. cerevisiae and P. pastoris. Besides, cell walls of several other non-Saccharomyces yeasts isolated from different habitats will be analysed to search for other potential hosts for surface display of proteins.Both existing, and newly investigated genetic systems will be used for surface display of six enzymes of the S-triazine complete degradation pathway from Pseudomonas ADP. Application of obtained strains in degradation of this world-wide commonly used herbicide will be explored. Described methodology would be used for surface display of several xylose reductases from several yeasts and the application of the obtained strains for enzymatic production of xylitol, combined with electrochemical regeneration of the necessary NAD(P)H. Potential of this method for application in biosensing will also be explored.]]></summary_en></project><project>
<id>3820</id><title_hr><![CDATA[Uloga ekonomskog sentimenta u tumačenju makroekonomskih trendova: metodološka unapređenja i nova područja primjene]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4299</user_id><user_firstLast_name>Mirjana Čižmešija</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-4697</code><acronim><![CDATA[MCPSIL2484BI]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, </scie_field_hr><scie_field_en>Economy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Ekonomski fakultet u Zagrebu]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Economics and Business]]></institution_en><team_members_id>21201</team_members_id><team_members_names><![CDATA[ Doktorand: Marina Matošec ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Business and Consumer Surveys, economic sentiment, leading indicators, behavioral economics, nonlinear econometrics]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The aim of this project is to incorporate psychological sentiment (obtained by Business and Consumer Surveys; BCS) in macroeconomic modeling. Namely, BCS offer direct assessment of the otherwise intangible factors such as economic agents’ perceptions and expectations. They measure the agents’ willingness to consume/invest/save, as opposed to their ability to do the same. Hence these psychological factors are crucial to understand the underlying market forces and agents’ behavior. The project goals are to:- Discern whether the non-rationality of consumers’ inflation expectations stems from the true inability of consumers to anticipate price changes, or did the researchers induce it themselves by falsely assuming that the distribution of BCS responses is normal. - Question whether the poor forecasting accuracy of BCS leading indicators can be improved through obtaining the optimal weights by (non)linear optimization.- Compose an optimism indicator based on BCS responses and determine the nature of its relationship with the stock market returns. Nonlinear time series analysis will be employed to test if the stock market reacts asymmetrically to positive/negative shocks in the economic sentiment.- Estimate the consumers’ willingness to buy realty and econometrically model its relationship with actual real estate prices.- Assess the value of BCS responses on households’ financial distress by correlating them to the common measures of poverty.- Employ the BCS data on managers’ perceptions to construct a liquidity indicator for the Croatian economy.The first 5 goals will be fulfilled by analyzing the proposed issues in EU countries, which will improve the general understanding of the role of sentiment in economic decision-making. Each of the stated research fields is expected to result in the publication of a paper in a reputable international journal. The results empirically obtained for Croatia will be synthesized in a scientific book at the end of the project.]]></summary_en></project><project>
<id>3823</id><title_hr><![CDATA[Hrvatsko longitudinalno istraživanje dobrobiti]]></title_hr><title_en><![CDATA[]]></title_en><user_id>67</user_id><user_firstLast_name>Ljiljana Kaliterna Lipovčan</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-2196</code><acronim><![CDATA[CRO-WELL]]></acronim><duration>02.01.2017 - 01.07.2021</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Psihologija, </scie_field_hr><scie_field_en>Psychology, </scie_field_en><institution_hr><![CDATA[Institut društvenih znanosti Ivo Pilar]]></institution_hr><institution_en><![CDATA[Institute of Social Sciences Ivo Pilar in Zagreb]]></institution_en><team_members_id>23199</team_members_id><team_members_names><![CDATA[ Doktorand: Lana Lučić ]]></team_members_names><keywords_hr><![CDATA[dobrobit, životni događaji, regulacija emocija, ličnost, longitudinalno istraživanje]]></keywords_hr><keywords_en><![CDATA[well-being, life events, affect regulation, personality, longitudinal study]]></keywords_en><summary_hr><![CDATA[Namjera nam je pokrenuti on-line longitudinalno istraživanje dobrobiti. Ovaj projekt ima dva cilja. Prvi cilj je provjeriti stupanj u kojem se dobrobit mijenja tijekom vremena i jesu li obrasci tih promjena različiti za ljudie različitih osobina. Drugi cilj je ispitati može li se dobrobit smatrati ne samo pokazateljem dobrog života, nego i nužnim dijelom povoljnih ishoda i pozitivnih životnih događaja, kao što je predloženo u teoriji proširenja i izgradnje pozitivnih emocija. Mi tvrdimo da visoke razine dobrobiti omogućavaju stvaranje kasnijih povoljnih životnih događaja i uvjeta za učinkovite strategije regulacije emocija. Tijekom razdoblja od četiri godine planiramo provesti on-line panel istraživanje u četiri vala. U istraživanju će biti korišten uzorak odraslih internet korisnika u Hrvatskoj. Bit će prikupljeni podaci o socio-demografskim varijablama, osobinama ličnosti, različitim sastavnicima dobrobiti, strategijama regulacije emocija i životnim događajima. U pilot testiranju bit će provedene fokus grupe u svrhu razvoja instrumenata. Kako bi privukli što je moguće više sudionika u istraživanje i smanjili osipanje tijekom provedbe uzastopnih valova istraživanja, puno će truda biti uloženo u promociju i oglašavanje projekta, kao i u informiranje i motiviranje sudionika da nastave sa sudjelovanjem u istraživanju. Praćenjem ljudi kroz duži period moći ćemo bolje objasniti povezanost između dobrobiti i životnih ishoda, kao i promjena u dobrobiti.]]></summary_hr><summary_en><![CDATA[We intend to launch on-line longitudinal research on well-being. The goal of the project is twofold. First, to examine the degree to which well-being fluctuates over time and whether patterns of well-being fluctuations are different for different types of people. Second, we aim to examine whether well-being can be considered not only as an indicator of good life, but also as a precondition of  positive outcomes and favourable life events, as proposed in the broaden-and-build theory of positive emotions. We posit that high levels of well-being enable the creation of later favourable life events and conditions by effective affect regulation strategies. During the four year project period, we plan to conduct on-line four-wave panel survey. Study sample will consist of adult internet users in Croatia. Through the survey, data on socio-demographic variables, personality traits, different components of well-being, affect regulation strategies and life events will be collected. Focus groups will be used as pilot tests to develop instruments. In order to recruit as many respondents as possible and to minimize attrition over the course of the consecutive waves lots of effort will be put into project promotion and advertising, as well as into informing and motivating participants to continue with the research. By following people through longer periods of time we would be able to better explain the relationships between well-being and life outcomes, as well as fluctuations in well-being.]]></summary_en></project><project>
<id>3826</id><title_hr><![CDATA[Hiperfosforilacija, agregacija i transsinaptički prijenos tau proteina u Alzheimerovoj bolesti: analiza likvora i ispitivanje potencijalnih neuroprotektivnih spojeva]]></title_hr><title_en><![CDATA[]]></title_en><user_id>11124</user_id><user_firstLast_name>Goran Šimić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-7200</code><acronim><![CDATA[ALZTAUPROTECT]]></acronim><duration>09.11.2016 - 08.05.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>22652</team_members_id><team_members_names><![CDATA[ Doktorand: Lea Langer Horvat ]]></team_members_names><keywords_hr><![CDATA[Alzheimerova bolest, cerebrospinalna tekućina (likvor), ELISA, neurofibrilarna degeneracija, neuroprotektivni spojevi, tau protein, tioflavin S ]]></keywords_hr><keywords_en><![CDATA[Alzheimer&#39;s disease, cerebrospinal fluid, ELISA, neurofibrillary degeneration, neuroprotective compounds, tau protein, thioflavine S]]></keywords_en><summary_hr><![CDATA[Za Alzheimerovu bolest (AB) ne postoji uzročno liječenje jer su brojni dosadašnji pokušaji intervencije temeljeni na amiloidnoj kaskadnoj hipotezi bili neuspješni. Usporedno s napretkom razumijevanja uloge tau proteina u patogenezi AB, metabolizam tau proteina je postao i važan terapijski cilj. Naime, smatra se da je u AB ravnoteža između kinaza i fosfataza tau proteina narušena, što dovodi do njegove hiperfosforilacije. Posljedično se povećava i frakcija tau proteina nevezanih za mikrotubule, pa se hiperfosforilirani tau monomeri vežu jedan za drugoga proizvodeći oligomere. Spajanje tau oligomera dovodi do oblikovanja sparenih uzvojitih filamenata, od kojih se sastoje sve neurofibrilarne promjene za koje je dokumentirano da predstavljaju najraniji neuropatološki događaj (tzv. &#39;&#39;pre-tangle&#39;&#39; stadij) od ključnog značaja za patogenezu AB. Ciljevi našeg projekta su: 1) bolje definirati odnos između bioloških biljega ranih stadija AB: ukupnih i fosforiliranih tau proteina, kao i amiloida ß u cerebrospinalnoj tekućini (likvoru) bolesnika s AD, MCI (blagi spoznajni poremećaj) i kontrolnih ispitanika. Uporabom inovativnog ELISA postupka i modificiranog eseja pomoću tioflavina S, u uzorcima likvora odrediti ćemo omjer između monomera i oligomera (agregata) tau proteina. Ti će novi podatci biti uspoređeni s kliničkim, neuropsihološkim i MRI nalazima; 2) testirati ćemo neke poznate i potencijalno neuroprotektivne spojeve (donepezil, klorgilin, nekoliko različitih flavonoida, te PF9601N i ASS234) na fosforilaciju tau proteina izazvanu okadaičnom kiselinom i nokodazolom u kulturama SH-SY5Y i P19 stanica. Epitope tau proteina fosforilirane na Thr181, Ser199 i Thr231 analizirati ćemo ELISA postupkom, a one na epitopima Thr202, Thr205, Ser396 i Ser404 pomoću westernske razložbe; i 3) istražiti ćemo biokemijski i imunocitokemijski transsinaptičko širenje neurofibrilarne degeneracije i razinu izraženosti tau mRNA nakon injekcije tau oligomera u entorinalnu moždanu koru miša.]]></summary_hr><summary_en><![CDATA[There is no effective treatment for Alzheimer’s disease (AD). As many drugs discovery attempts based on the amyloid cascade hypothesis have not been successful, tau protein has become an increasingly important therapeutic target owing to advances in understanding of its role in AD pathogenesis. In AD, the balance of tau kinase and phosphatase activity is shifted, creating a highly phosphorylated species of tau. This raises the fraction of unbound tau, which is no longer attached to microtubules, allowing for monomeric hyperphosphorylated tau to bind to one another to produce oligomers. Fusion of these oligomeric species leads to the formation of paired helical filaments, the primary constituent of neurofibrillary changes, which have been documented to be an early and pivotal event (so-called „pre-tangle“ stage) in the pathogenesis of AD. Our aims are: 1) to define better the relationship between the early AD biomarkers total and phospho-tau proteins, as well as amyloid ß in cerebrospinal fluid (CSF) of AD, MCI (mild cognitive impairment), and control subjects. By using innovative ELISA and modified thioflavin S binding assay on CSF samples, we will also assess the ratio between monomer and oligomer (aggregated) tau species. These new data will be correlated to clinical, neuropsychological, and MRI findings; 2) to test the effect of several known and potentially neuroprotective compounds (donepezil, clorgyline, several flavonoids, PF9601N and ASS234, among others) on tau phosphorylation induced by okadaic acid and nocodazole in SH-SY5Y and P19 cell cultures. Tau epitopes phosphorylated at Thr181, Ser199 and Thr231 residues will be analyzed by ELISA, while p-tau epitopes at Thr202, Thr205, Ser396 and Ser404 will be analyzed by Western blot; and 3) to investigate biochemically and immunocytochemically the trans-synaptic spreading of neurofibrillary degeneration and tau mRNA expression after the injection of tau oligomers in the mouse entorhinal cortex.]]></summary_en></project><project>
<id>3827</id><title_hr><![CDATA[Akrobacije molekulskih kristala - termoodskočni materijali za novu generaciju aktuatora]]></title_hr><title_en><![CDATA[]]></title_en><user_id>13189</user_id><user_firstLast_name>Željko Skoko</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-7656</code><acronim><![CDATA[AKROBATOO MATER]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>23052</team_members_id><team_members_names><![CDATA[ Doktorand: Teodoro Klaser ]]></team_members_names><keywords_hr><![CDATA[termoodskočni efekt, aktuatori, strukturna analiza, rendgenska difrakcija, kvantnomehaničko modeliranje]]></keywords_hr><keywords_en><![CDATA[thermosalient effect, actuators, structure analysis, XRD, DFT calculations]]></keywords_en><summary_hr><![CDATA[Ciljano dizajniranje novih aktuatorskih materijala, koji su u stanju pružiti odgovor na vanjsku pobudu (toplinsku ili svjetlosnu) u obliku brzog, revezibilnog i kontroliranog mehaničkog kretanja trenutno predvodi istraživanja u znanosti o materijalima. Među takvim materijalima, nekoliko slučajno otkrivenih primjera kristala koji skaču za vrijeme grijanja, do daljina nekoliko tisuća puta većih od njihovih dimenzija u vremenu kraćem od 1 ms, pružaju impresivan prikaz pretvorbe toplinske energije u mehanički rad. Takvi termoodskočni (eng. thermosalient) kristali su biomimetički, nepolimerni samo-aktuatori par excellance. Ipak, zbog ekskluzivnosti ovog fenomena, i također zbog izuzetne složenosti analitičke metodologije za njegovu karakterizaciju, razlozi koji izazivaju ovu kolosalnu samo-aktuaciju ostaju nerazjašnjeni. Unutar projekta, odredit će se razlog postojanja termoodskočnog efekta u odabranim sustavima organskih molekulskih kristala (trans, trans, anti, trans, trans perhidropiren, L-piroglutamska kiselina te N’-2-propiliden-4-hidroski-benzohidrazid) koji su već poznati u literaturi, ali su još nerazjašnjeni. Nadalje, istraživanja će se proširiti na skupinu spojeva dobivenu odabranim i pažljivim modificiranjem spojeva za koje je efekt prethodno ustanovljen. Za očekivati je da će termoodskočni efekt biti izuzetno osjetljiv na suptilne promjene u kemijskom sastavu stoga će se omogućiti određivanje uvjeta za modeliranje novih materijala s termoodskočnim svojstvima. S ciljem elucidacije termoodskočnog fenomena, ovaj projekt predstavlja prvi sustavni pokušaj određivanje međuigre između termodinamičkih, kinematičkih, strukturnih i makroskopskih faktora termoodskočnog efekta pomoću difrakcijskih (XRD), mikroskopskih (hot-stage), spektroskopskih (FTIR, UV/VIS) i termičkih (DTA/DSC/TG) tehnika. Ispitivani sustavi također će se izučavati kvantomehaničkim modeliranjem (DFT). ]]></summary_hr><summary_en><![CDATA[Targeted design of new actuating materials which are capable of fast, reversible and controllable mechanical motion in response to external stimuli (thermal or light) is at the frontier of the contemporary materials science research. Among these, the few serendipitously discovered examples of crystals that suddenly jump while heated, to distances several thousand times larger than their own dimension in less than 1 ms, provide the most impressive display of the conversion of thermal energy into mechanical work. These thermosalient crystals are biomimetic, nonpolymeric self-actuators par excellence. Yet, due to exclusivity of the phenomenon, but also due to the complexity of analytical methods for its characterization, reasons behind this colossal self-actuation remain unexplained. Within this project, reasons behind the thermosalient effect in chosen systems of organic molecular crystals (trans,trans,anti,trans,trans perhydropyrene, L-pyroglutamic acid and N&#39;-2-propylidene-4-hydroxy-benzohydrazide), already reported in the literature – but unexplained, will be revealed. Furthermore, research will broaden to include a group of compounds obtained by careful and planned modification of the compounds in which the effect has already been observed. It is to be expected that the thermosalient effect is very sensitive to the subtle changes in the chemical composition so this will enable determination of necessary chemical/structural parameters so as to arouse the thermosalient effect in the system. With the aim of final elucidation of the thermosalient phenomenon, this project represents first systematic attempt to disentangle the interplay between the thermodynamic, kinematic, structural and macroscopic factors that drive the thermosalient effect by employing various diffraction (XRD), microscopic (hot stage), spectroscopic, (FTIR, UV/VIS) and thermal (DTA/DSC/TG) techniques. Systems under study will also be investigated by the means of quantomechanical modeling (DFT). ]]></summary_en></project><project>
<id>3828</id><title_hr><![CDATA[Razvoj višenamjenskog sustava upravljanja zemljištem]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3172</user_id><user_firstLast_name>Vlado Cetl</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-9505</code><acronim><![CDATA[DEMLAS]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Geodezija, </scie_field_hr><scie_field_en>Geodesy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Geodetski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Geodesy]]></institution_en><team_members_id>21294</team_members_id><team_members_names><![CDATA[ Doktorand: Dragan Divjak ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Land Administration System, Land Registers, Land Management, Sustainable Development, Geoinformation]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The primary purpose of a land administration system (LAS) is the registration of legal or other formal relations of persons to land. Besides its primary purpose, land administration system can and should also serve as a basis for land management. Different to the land administration, land management is a set of processes ensuring that the land is used in an efficient and sustainable manner. Unfortunately, land administration systems are rarely able to fulfill such additional requirements, even in the developed countries.This project aims at finding what needs to be done in order to transform a traditional land administration system into a modern multipurpose land administration system (MLAS), which can efficiently support land management. Our hypothesis says that such a transformation can be done by improving two aspects of a LAS, its efficiency and its usability.Under efficiency we consider the ability of a LAS to update its data quickly whilst ensuring the consistency and correctness thereof. Within the project we will investigate options for outsourcing the preparation of transactions to private sector and the possibilities to more efficiently collect field data within the improved process of updating LAS data.Even more important that its efficiency, is the usability of a LAS. This is the second aspect that we try to improve within the project. Besides the mere registration of the land, MLAS must be able to efficiently support processes of land valuation, urban planning and various rearrangements aiming to increase agricultural productivity of the land. Within the project we will investigate which additional data needs to be collected, processed and stored within the LAS in order to enable efficient support to land management processes.As a starting point for the research we use our previous research closely related to the topics of land administration and land management, and the Land Administration Domain Model (LADM), which recently became the ISO standard.]]></summary_en></project><project>
<id>3830</id><title_hr><![CDATA[Mikrobna ekologija voda kao pokazatelj zdravstvenog stanja okoliša ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5800</user_id><user_firstLast_name>Damir Kapetanović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-4841</code><acronim><![CDATA[AQUAHEALTH ]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Veterinarska medicina, </scie_field_hr><scie_field_en>Veterinary medicine, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>21141</team_members_id><team_members_names><![CDATA[ Doktorand: Anamarija Kolda ]]></team_members_names><keywords_hr><![CDATA[bakterija, rezistencija, mikrobna ekologija, riba, kvaliteta vode, sediment, zdravlje ljudi]]></keywords_hr><keywords_en><![CDATA[bacteria, resistance, microbial ecology, fish, water quality, sediment, human health]]></keywords_en><summary_hr><![CDATA[Većina studija o mikrobnoj ekologiji vodenog okoliša usredotočena je na odvojene dijelove vodenog ekosustava. našim projektom predlažemo opsežnu studiju bakterijske zajednice u vodenom stupcu, sedimentu i ribama kao pokazateljima zdravstvenog stanja vodenog okoliša i njegovih mogućih implikacija na ljudsko zdravlje. Projektom se nastoji istražiti genetsku raznolikost bakterijskih izolata u vodenom okolišu, od površine do dna, odnose između izolata iz okoliša, onih iz zdravih riba i onih iz riba s kliničkim simptomima bolesti. Ovi podaci su neophodni za predviđanje nastanka i putova širenja bakterijskih pokazatelja kvalitete vode, kao i potencijalno patogenih bakterija, kako za ribe, tako i za ljude. Istražit će se profili rezistencije na antimikrobne lijekove, kako bi se utvrdilo potencijalnu vezu između odabranih modelnih bakterija i njihove rezistencije te učinak različitih uzročnika stresa iz okoliša. Cjelokupna strategija radnog plana je primijeniti multidisciplinarni pristup za istraživanje složenog bakterijskog ekosustava u vodenom okolišu (vidi Sliku 1). Unutar trenutnog partnerstva, četiri zadatka su identificirana, za rješavanje specifičnih problema u vezi s mikrobnom ekologijom vodenog okoliša: 1. Plan i obrazloženje uzorkovanja, 2. Ribe kao modelni organizmi, 3. Odabrane modelne bakterije i 4. Utjecaj na zdravlje ljudi. Istraživanje će se provesti korištenjem infrastrukture i stručnosti prisutne u okviru konzorcija. Projekt će okupiti state of the art istraživanja iz trenutno fragmentiranih područja. Ovo će stvoriti osnovu za daljnje djelovanje u prevenciji bolesti i poremećaja zdravlja riba zbog djelovanja uvjetno patogenih bakterija. Poboljšana održivost okoliša će poboljšati ukupnu ekonomsku održivost sektora akvakulture. To će biti od velikog interesa za širu javnost, proizvođače, potrošače riba i ribljih proizvoda, kao i kreatore i izvršitelje zakona.]]></summary_hr><summary_en><![CDATA[The majority of studies in aquatic microbial ecology focus on the separate segments of aquatic ecosystem. Our project proposes comprehensive study of bacterial community within water column, sediment and fish as indicator of the aquatic environmental health status and its potential implications to human health. The project seeks to understand the genetic diversity of bacterial isolates in the aquatic environment, the relationships between environmental isolates, those from the healthy fish and from fish with clinical symptoms. These data are necessary to predict the origin and spreading pathways of bacterial indicators of water quality, as well as potentially pathogenic bacteria, both for fish and humans. Antibiotic resistance profiles will be explored to determine a potential link between selected model bacteria and their resistance, and the effects of different environmental stress factors. The overall strategy of the work plan is to implement a multidisciplinary approach for the examination of the complex bacterial ecosystem in the aquatic environment. Within the partnership, four tasks have been identified, equating to resolving of specific problem connected with aquatic microbial ecology: 1. Sampling network design and rationale, 2. Fish as model organisms, 3. Selected Model Bacteria and 4. Impact on human health. Research will be carried out using the infrastructures and expertise present within the consortium. The project will bring together state of the art research from currently fragmented research fields in the same area. This will create a basis for further actions in the prevention of diseases and disorders in fish caused by potential pathogens. Improved environmental sustainability will enhance the overall economical viability of the aquaculture sectors, concerned with lowering environmental impacts resulting from current practices. This will be of high interest to the general public, fish consumers, policy makers and policy administrators.]]></summary_en></project><project>
<id>3832</id><title_hr><![CDATA[Primjena mikrosimulacijskih modela u analizi poreza i socijalnih naknada u Hrvatskoj]]></title_hr><title_en><![CDATA[]]></title_en><user_id>842</user_id><user_firstLast_name>Ivica Urban</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-1733</code><acronim><![CDATA[AMMATSBC]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, </scie_field_hr><scie_field_en>Economy, </scie_field_en><institution_hr><![CDATA[Institut za javne financije]]></institution_hr><institution_en><![CDATA[Institute of Public Finance]]></institution_en><team_members_id>21291</team_members_id><team_members_names><![CDATA[ Doktorand: Martina Pezer ]]></team_members_names><keywords_hr><![CDATA[mikrosimulacije, modeli, porezi, socijalne naknade, EUROMOD, reforma, ponuda rada, zaposlenost, raspodjela dohotka, siromaštvo]]></keywords_hr><keywords_en><![CDATA[microsimulation, models, taxes, social benefits, EUROMOD, reform, labour supply, employment, income distribution, poverty]]></keywords_en><summary_hr><![CDATA[Mikrosimulacijski model poreza i socijalnih naknada (MSMPN) za svakog pojedinca iz skupa mikropodataka izračunava odgovarajuće iznose poreznih obveza i socijalnih naknada na koje osoba ima pravo. MSMPN omogućuje ex ante pregled učinaka promjena u sustavu poreza i socijalnih naknada i zbog toga je iznimno vrijedan alat u analizi i planiranju reforme.Za razliku od ostalih zemalja EU-a, gdje je uobičajena upotreba MSMPN-a, u Hrvatskoj je razvoj mikrosimulacijskih modela još uvijek u začetku.Zbog toga je svrha ovog projekta primijeniti mikrosimulacijske modele hrvatskih poreza i socijalnih naknada u analizama za potrebe vođenja javne politike i u akademskim analizama. Primjenom mikrosimulacijskih modela u analizi aktualnih ekonomsko-političkih problema ovaj projekt će pokazati korisnost mikrosimulacijskih modela te privući pozornost čelnika javne uprave i akademskih istraživača u Hrvatskoj.Istraživanje ima tri cilja:(1) Razviti mikrosimulacijski model hrvatskih poreza i naknada – miCROmod:miCROmod će biti konvencionalni statički aritmetički MSMPN koji simulira doprinose za socijalno osiguranje, porez na dohodak, zajamčenu minimalnu naknadu, doplatak za djecu, roditeljske naknade i naknadu za nezaposlene. Osim toga, razvit će se: (a) dodatak za jedinice lokalne vlasti, kojim se modeliraju porezi i socijalne naknade u Gradu Zagrebu, i (b) bihevioralni dodatak, koji će simulirati utjecaj promjena instrumenata poreza i socijalnih naknada na ponudu rada i na bruto plaće.(2) Upotrijebiti miCROmod i EUROMOD u analizi poreza i socijalnih naknada:miCROmod i EUROMOD (MSMPN za sve zemlje EU) koristit će se u analizi učinka raznih reformi na nejednakost u raspodjeli dohotka, stope siromaštva i poticaje za rad, a to su reforme: (a) Potpora za djecu, (b) Poreza na dohodak, (c) Instrumenata za povećanje isplativosti rada i (d) Lokalnih socijalnih naknada.(3) Predstaviti djelovanje mikrosimulacijskih modela čelnicima javne uprave i istraživačima.]]></summary_hr><summary_en><![CDATA[Microsimulation model of taxes and social benefits (MSMTBs) calculates for each individual person from a set of microdata the corresponding amounts of taxes payable and social benefits receivable. MSMTBs allow ex ante review of the effects of changes in tax-benefit system. Therefore, they are particularly valuable in the reform analysis and planning.Unlike in other EU countries, where the use of MSMTBs is widespread, the development of MSMTBs in Croatia is still in its infancy.Therefore, the purpose of this project is to apply microsimulation models of Croatian taxes and benefits in public policy and academic analysis. By application of MSMTBs in analysing contemporary economic and policy problems, the project will demonstrate the usefulness of these models, and attract the attention of public administration leaders (PALs) and researchers in Croatia.The research project has three objectives:(1) Develop the microsimulation model of Croatian taxes and benefits – miCROmod:miCROmod will be a conventional static arithmetic MSMTB that simulates social security contributions, personal income tax, guaranteed minimum income, child benefit, parental benefits and unemployment benefit. miCROmod will also include: (a) a local government supplement, modelling taxes and benefits in the City of Zagreb and (b) a behavioural supplement, simulating the impact of changes of tax-benefit instruments on the labour supply and gross wages.(2) Employ miCROmod and EUROMOD in the analysis of tax-benefit reform scenarios:miCROmod and EUROMOD (a comprehensive MSMTB for the EU) will then be used in the the analysis of the effect of a number of tax-benefit reforms on income inequality, poverty rates and incentives to work. These reforms cover: (a) Child benefits, (b) Personal income tax (c) In-work policies, and (d) Local social benefits.(3) Present the performance of miCROmod and EUROMOD to PALs and researchers.]]></summary_en></project><project>
<id>3835</id><title_hr><![CDATA[Divlja loza (Vitis vinifera subsp. sylvestris): vrijedan izvor gena za oplemenjivanje vinove loze]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1507</user_id><user_firstLast_name>Goran Zdunić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-4883</code><acronim><![CDATA[WI.GRA.GENE]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Institut za jadranske kulture i melioraciju krša]]></institution_hr><institution_en><![CDATA[Institute for Adriatic Crops and Karst Reclamation in Split]]></institution_en><team_members_id>21312</team_members_id><team_members_names><![CDATA[ Doktorand: Katarina Lukšić ]]></team_members_names><keywords_hr><![CDATA[divlja loza, SSR markeri, domestikacija, ampelografija, genetika]]></keywords_hr><keywords_en><![CDATA[wild grape, SSR markers, domestication, amperlography, genetic]]></keywords_en><summary_hr><![CDATA[Divlja loza (Vitis vinifera subsp. sylvestris Gmel.) predak kultivirane vinove loze nikad nije detaljno istražena u Hrvatskoj. Prirodno stanište ove ugrožene europske biljke (prema IUCN Crvenoj listi ugroženih biljnih vrsta) je relativno netaknuta šuma u neposrednoj blizini vode. Genetska sličnost divlje i kultivirane loze je vrlo visoka (uključujući seksualnu kompatibilnost) iako divlja loza nije pretrpjela strog selekcijski proces domestifikacije. Dakle, tu postoje jedinstvene osobine i aleli još uvijek prisutni u genomu divlje loze, koje treba istražiti i koristiti u suvremenom cijepljenju vinove loze. Glavni ciljevi ovog projekta su i) procijeniti genetsku i fenotipsku raznolikost divlje loze u istraživanoj regiji i njihovu povezanost sa autohtonim sortama vinove loze u uzgoju, ii) sačuvati genetsku raznolikost, iii) istražiti neke morfološke i genetske karakteristike divlje loze koje su od posebnog interesa u programima cijepljenja i mogu pomoći u transferu određenih korisnih gena koji nisu bili cijenjeni tijekom domestifikacije i selekcije od strane ljudi jedinstven je doprinos ovog područja istraživanja. Ovaj projekt će omogučiti osnivanje genetskog laboratorija za DNA karakterizaciju vinove loze na IJK, okupljanje tima znanstvenika usmjerenih na divlju lozu omogućava multidisciplinarni uvid i povečanje vidljivosti i suradnje hrvatske istraživačke grupe sa međunarodnom znanstvenom zajednicom za lozne genetske resurse i istraživačku suradnju.]]></summary_hr><summary_en><![CDATA[The wild grapevine (Vitis vinifera subsp. sylvestris Gmel.) is an ancestor of cultivated grapevine and has never been explored in detail in Croatia. Natural native habitats for this endangered European plant (according to the IUCN Red list of threatened plant species) are relatively untouched forest with significant nearby water. The genetic similarity between wild and cultivated grapes is very high (including sexual compatibility) although the wild grape has not passed through the strict selection process of domestication. Thus, there are possible unique traits and alleles still present in the wild grape genome, which should be explored and used in modern grapevine breeding. The main objectives of this project are to i) assess the overall genetic and phenotypic diversity of wild grape in this region and their relatedness to local cultivated grapevine, ii) preserve the genetic diversity, iii) investigate some morphological and genetic characteristics of wild grape that are of special interest to breeding programs to aid transfer of certain beneficial genes that were not favoured during domestication and human selection bringing unique contribution to this research field. This project will enable the installation of a genetic laboratory for grapevine DNA characterization at the IAC, gather a team of scientists focused on wild grape to deliver multidisciplinary insight, and increase the visibility and collaboration of this Croatian research group with the international scientific community for grape genetic resources, and research collaboration.]]></summary_en></project><project>
<id>3837</id><title_hr><![CDATA[Genska tipizacija patogena prenosivih krpeljima analizom sekvenici više gena: popunjavanje praznina između životinjskih rezervoara, krpelja i ljudi]]></title_hr><title_en><![CDATA[]]></title_en><user_id>939</user_id><user_firstLast_name>Relja Beck</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-7192</code><acronim><![CDATA[GENOTICKTRECK]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Veterinarska medicina, </scie_field_hr><scie_field_en>Veterinary medicine, </scie_field_en><institution_hr><![CDATA[Hrvatski veterinarski institut]]></institution_hr><institution_en><![CDATA[Croatian Veterinary Institute]]></institution_en><team_members_id>21270</team_members_id><team_members_names><![CDATA[ Doktorand: Daria Jurković ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[tick-borne pathogens, multilocus sequnce genotyping, pathogen distribution, animals, humans]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Globalization and climate change have an unprecedented worldwide impact on emergence and re-emergence of animal diseases, especially vector borne zoonoses.. Diseases that used to be limited only to tropical areas are now increasingly spreading to other previously unaffected regions. A wide variety of pathogens that can be propagated and transmitted by ticks infect humans, wildlife or domestic animals. Over the past decades, the scientific landscape of tick-borne diseases has changed significantly due to advances in molecular biology. Several new rickettsial and ehrlichial diseases, as well as new Borrelia and Babesia genotypes have been confirmed, and consequently, improved diagnostics of emerging diseases in veterinary and human medicine. A number of cases of tick-borne encephalitis (TBE) and Lyme disease have increased. To better understand the importance of tick-borne diseases, a proposed project follows an interdisciplinary approach involving physicians, veterinarians and biologists, also known as One Health approach. Since the cultivation of pathogens is difficult and slow, and for number of pathogens this cultivation is impossible, multylocus sequence typing MLST approach will be used for their genetic characterization of Babesia spp., Borrelia burgdorferi s. l., B. miyamotoi, Rickettsia spp., Anaplasma spp, Ehrlichia spp. Bartonella spp., Neoehrlichia mikurensis, Tick-borne encephalitis virus, Coxiella burnetii and Francisella tularensis from animal reservoirs, ticks and humans. Another objective will be to map tick species, since they were investigated 40 years ago, and to confirm species with PCR and sequencing. Application of genetic typing of multiple genes allows a detailed differentiation of genotypes and their heterogeneity. In this way, the genetic variability of the isolates, their geographical distribution and population genetic structure, as well as transmission routes of various isolates within ticks and their natural reservoirs, will be defined.]]></summary_en></project><project>
<id>3840</id><title_hr><![CDATA[Heuristička optimizacija u kriptologiji]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6984</user_id><user_firstLast_name>Domagoj Jakobović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-2489</code><acronim><![CDATA[EvoCrypt]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>22841</team_members_id><team_members_names><![CDATA[ Doktorand: Karlo Knežević ]]></team_members_names><keywords_hr><![CDATA[heuristička optimizacija, evolucijski algoritmi, kriptografija, kriptoanaliza, sklopovska izvedba]]></keywords_hr><keywords_en><![CDATA[heuristic optimzation, evolutionary computation, cryptography, cryptanalysis, hardware implementation]]></keywords_en><summary_hr><![CDATA[Cilj ovoga projekta je primjena stohastičkih i determinističkih algoritama optimizacije, kao i metoda strojnog učenja, na aktualnim problemima u kriptologiji. U okviru projekta istražit će se učinkovitost optimizacijskih algoritama, s naglaskom na evolucijsko računanje, primijenjenih na probleme oblikovanja nelinearnih elemenata za kriptografske algoritme, kao što su Booleove funkcije i S-kutije. Dio nastojanja bit će posvećen i optimizaciji sklopovske izvedbe tih elemenata, prije svega u kontekstu povećavanja propusnosti. Osim toga, prijedlog razmatra i problem učinkovitog traženja parametara napada umetanjem pogreške. Kako bi rezultati projekta bili dostupni široj zajednici, dodatna namjena projekta je stvaranje odgovarajuće programske potpore i optimizacijskih algoritama u obliku pratećeg skupa programskih alata, kako bi se omogućila primjena rezultata istraživačima u ovome području.]]></summary_hr><summary_en><![CDATA[This proposal aims at successful application of stochastic and deterministic optimization algorithms, as well as methods from the machine learning community, to current problems in cryptology. The project will investigate the efficiency of stochastic optimization algorithms, with evolutionary computation in particular, applied to the problems of creating nonlinear primitives for cryptography, such as Boolean functions and S-boxes. A part of this goal will also be devoted to optimization of hardware implementations of those primitives, primarily in the context of throughput maximization. Additionally, the proposal considers the problem of efficient search for parameters of successful fault analysis. The results of the project would not be easily attainable to the wider community without an appropriate collection of software tools for evaluation of candidate solutions to these problems and appropriate optimization algorithms. The final objective of this project is the creation of an accompanying open-source software tool collection to facilitate usage by researchers in the field.]]></summary_en></project><project>
<id>3842</id><title_hr><![CDATA[Kohortna studija rođenih na istočnojadranskim otocima]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3126</user_id><user_firstLast_name>Saša Missoni</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-4603</code><acronim><![CDATA[CRIBS]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Etnologija i antropologija, </scie_field_hr><scie_field_en>Ethnology and anthropology, </scie_field_en><institution_hr><![CDATA[Institut za antropologiju]]></institution_hr><institution_en><![CDATA[Institute for Anthropological Research]]></institution_en><team_members_id>24976</team_members_id><team_members_names><![CDATA[ Doktorand: Tonko Carić ]]></team_members_names><keywords_hr><![CDATA[metabolički sindrom, kohortna studija rođenih, rani razvoj, prevencija, čimbenici rizika]]></keywords_hr><keywords_en><![CDATA[metabolic syndrome, birth cohort, early development, prevention, risk factors]]></keywords_en><summary_hr><![CDATA[Metabolički sindrom (MetS) je vodeći uzrok obolijevanja i smrtnosti, s velikim utjecajem na zdravlje stanovništva i visokim troškovima liječenja. Njegova prevalencija je više od 30 % u općoj populaciji Hrvatske, uz posebno visoku stopu na hrvatskim otocima, do 58 %. Specifična obilježja istočnojadranskih otoka (genetički izolati s visokom razinom srođivanja, s miješanjem tradicionalnog i tranzicijskog životnog stila te stalnim depopulacijskim procesima) predstavljaju temelj za razvoj obrazaca čimbenika rizika koji utječu na pojavu MetS-a. Ovaj projekt je pilot-studija čiji su ciljevi: procijeniti prevalenciju poznatih čimbenika rizika (bioloških, ekoloških i ponašajnih) za razvoj MetS-a u ciljnim hrvatskim populacijama istočnojadranskih otoka i susjednog kopnenog područja te koristiti dobivene rezultate kao temelj za razvoj strategije intervencije. Populacijske kohortne studije trudnica i rođene djece su posebno pogodne za proučavanje ranih odrednica zdravlja i bolesti, koje se javljaju još u fetalnom razdoblju i djetinjstvu. Longitudinalni istraživački pristup će se primijeniti na reprezentativnom uzorku od 713 ispitanika u svakoj od dviju skupina: trudnica i njihove djeca u ciljnim populacijama otoka (Hvar, Brač i Vis) i susjednog kopnenog područja Splitsko-dalmatinske županije. Ishod projekta bit će otkrivanje skupova bitnih čimbenika rizika razvoja MetS-a u ciljnim populacijama. Dugoročni ishod je postupno razvijanje osnove djelotvorne strategije intervencije usmjerene na bitne čimbenike rizika nastanka MetS-a. Važnost nalaza ove pilot-studije je stvaranje temelja budućeg usmjerenijeg, populacijski prilagođenog modela rane intervencije, uključivanjem velikog broja bitnih čimbenika rizika za razvoj MetS-a, što će predstavljati značajan doprinos javnom zdravlju. Saznanja i iskustva stečena na temelju provedenih istraživanja doprinijet će stvaranju učinkovitijih programa promocije zdravlja, uzimajući u obzir utvrđene lokalne sociokulturne i okolišne specifičnosti.]]></summary_hr><summary_en><![CDATA[Metabolic syndrome (MetS) is the leading cause of high morbidity and mortality, with enormous impact on population health and medical costs. Its prevalence is more than 30% in the general Croatian population, with especially high rate on Croatian islands, up to 58%. Specific features of the Eastern Adriatic Islands (EAI) (genetic isolates with high level of inbreeding, mixing traditional and transitional lifestyle and continuous depopulation processes) represent a basis for development of specific MetS risk factor patterns. This project is a pilot study with the aims to: assess the prevalence of known risk factors (biological, environmental and behavioral) for the MetS in EAI and nearby mainland area of the targeted Croatian populations and to use this information as a base to develop an intervention strategy. Population-based pregnancy and birth cohort studies are particularly salient for studying early origins of health and disease that begin in fetal life and infancy. A longitudinal approach will be used on a representative sample of 713 participants in each group: pregnant women and children in the targeted populations of the islands (Hvar, Brač and Vis) and nearby mainland area of of the Split-Dalmatia County. The outcome of the project is revealing sets of relevant risk factors for the development of MetS in the studied Croatian populations. The long-term outcome is progressive development of a base for an effective intervention strategy, directed at relevant risk factors for MetS. The importance of this pilot study is developing foundations for a better focused population adjusted model of early intervention in the future. It will include a large number of relevant risk factors for MetS, which will contribute to beneficial public health outcomes. Knowledge and experiences, acquired in this research will contribute to the creation of programs for health promotion, taking into account local socio-cultural and environmental characteristics.]]></summary_en></project><project>
<id>3846</id><title_hr><![CDATA[Safe human-robot interaction in logistic applications for highly flexible warehouses (SafeLog)]]></title_hr><title_en><![CDATA[]]></title_en><user_id>378</user_id><user_firstLast_name>Ivan Petrović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-8551</code><acronim><![CDATA[]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Temeljne tehničke znanosti, </scie_field_hr><scie_field_en>Basic engineering sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>25415</team_members_id><team_members_names><![CDATA[ Doktorand: Goran Popović ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>3847</id><title_hr><![CDATA[Kinetochore oscillations in mitotic metaphase]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6276</user_id><user_firstLast_name>Nenad Pavin</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-5291</code><acronim><![CDATA[]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>22681</team_members_id><team_members_names><![CDATA[ Doktorand: Agneza Bosilj ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>3848</id><title_hr><![CDATA[Potencijali i prepreke razvoja socijalnih supermarketa u Srednjoj i istočnoj Europi]]></title_hr><title_en><![CDATA[]]></title_en><user_id>11297</user_id><user_firstLast_name>Blaženka Knežević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-9303</code><acronim><![CDATA[SSMCEE]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, </scie_field_hr><scie_field_en>Economy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Ekonomski fakultet u Zagrebu]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Economics and Business]]></institution_en><team_members_id>13029</team_members_id><team_members_names><![CDATA[ Doktorand: Petra Škrobot ]]></team_members_names><keywords_hr><![CDATA[maloprodaja, oblici maloprodaje, društvena odgovornost, socijalni supermarketi, socijalne inovacije]]></keywords_hr><keywords_en><![CDATA[retailing, retail formats, social responsibility, social supermarkets, social innovations]]></keywords_en><summary_hr><![CDATA[Ekonomska kriza uzrokovala je porast nezaposlenosti i povećanje siromaštva u Europskoj uniji. S druge strane, tradicionalni kanali distribucije obično stvaraju viškove koji se mogu učinkovitije iskoristiti. Istraživanja pokazuju da socijalne samoposluge, kao novi maloprodajni oblik, postaju sve važniji čimbenik u smanjenju siromaštva u cijeloj Europi putem učinkovitije raspodjele stvorenih viškova roba. Socijalne samoposluge po svojoj osnovnoj svrsi i načinu poslovanja, značajno se  razlikuju u odnosu na tradicionalne maloprodajne oblike, a u postojećoj znanstvenoj literaturi još uvijek nisu istražene u dovoljnoj mjeri, posebice u zemljama Srednje i istočne Europe. Kako socijalne samoposluge temelje svoje djelovanje na filantropskim osnovama, volontiranju i donacijama, a već na nekim tržištima značajno utječu na strukturu prihoda tradicionalnih maloprodavača, ova tema zahtijeva multidisciplinarni pristup kako bi se: (a) pojasnila njihova trenutna pozicija i njihov utjecaj na opću socio-ekonomsku situaciju na pojedinim tržištima, (b) istražio pravni okvir koji je utemeljen u onim zemljama u kojima su socijalni supermarketi postigli visok stupanj razvoja, posebno u području poreznog zakonodavstva i zakonodavstva prava potrošača, (c) istaknula pitanja upravljanja u vezi organizacije rada volontera ili zaposlenika, i (d) objasnili specifični problemi učinkovite organizacije ulazne logistike te distribucije roba i usluga unutar socijalnih supermarketa. Zato će projektni tim obuhvatiti stručnjake iz područja trgovine, upravljanja maloprodajom, upravljanja neprofitnim organizacijama, korporativnih financija, fiskalnih sustava i socijalnog rada iz nekoliko znanstvenih institucija iz četiri države Srednje i istočne Europe.]]></summary_hr><summary_en><![CDATA[The ongoing economic crisis caused the rising unemployment and the increasing poverty in the European Union. On the other hand, the traditional distribution channels usually generate surpluses that can be effectively used to decrease problems of poverty. Research studies show that Social supermarkets, as a new retail, are becoming increasingly important factor in reducing poverty across Europe throughout more efficient distribution of generated surpluses of goods. Social supermarkets at their core purpose and mean of operations are substantially different compared to the traditional retail formats, and in the current scientific literature they have not been sufficiently investigated so far, especially in Central and Eastern European countries. As social supermarkets base their operation on philanthropic foundations, volunteering and donations, and already in some markets significantly affect the structure of revenues of the traditional retailers, this topic requires a multidisciplinary approach in order: (a) to clarify their current position and their impact the general socio-economic situation in the particular markets, (b) to investigate the legal framework that has been established by those countries in which social supermarkets reached a high level of development, particularly in the area of tax legislation and consumer rights legislation, (c) to assess management issues regarding work organization of volunteers or employees, and (d) to explain particular problems of the effective organization of input logistics and distribution of goods and services within social supermarkets. Therefore, the project team will include experts from the fields of retailing, retail management, management of nonprofit organizations, corporate finance, fiscal systems and social work from several scientific institutions from four Central and Eastern European countries.]]></summary_en></project><project>
<id>3851</id><title_hr><![CDATA[Razumijevanje, praćenje i analiziranje transparentnosti proračuna lokalnih jedinica: Primjer Hrvatske i Slovenije - Indeks otvorenosti lokalnih proračuna]]></title_hr><title_en><![CDATA[]]></title_en><user_id>13372</user_id><user_firstLast_name>Katarina Ott</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-8730</code><acronim><![CDATA[OLBI]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, </scie_field_hr><scie_field_en>Economy, </scie_field_en><institution_hr><![CDATA[Institut za javne financije]]></institution_hr><institution_en><![CDATA[Institute of Public Finance]]></institution_en><team_members_id>21290</team_members_id><team_members_names><![CDATA[ Doktorand: Branko Stanić ]]></team_members_names><keywords_hr><![CDATA[Local government, budget transparency, Open local budget index, Croatia, Slovenia]]></keywords_hr><keywords_en><![CDATA[lokalne jedinice, transparetnost proračuna, Indeks otvorenosti lokalnih proračuna, Hrvatska, Slovenija]]></keywords_en><summary_hr><![CDATA[Transparentnost proračuna lokalnih jedinica (TPLJ) od iznimne je važnosti budući da odluke lokalnih vlasti o trošenju javnih sredstava utječu na svakog građanina.  TPLJ označava u kojoj mjeri i koliko jednostavno građani mogu pristupati informacijama o prihodima i rashodima lokalnih proračuna. Transparentnost proračuna prvi je korak prema demokratizaciji proračunskog procesa i uključivanju građana u oblikovanje politika  i raspodjelu sredstava. Netransparentan proračun ne može se valjano analizirati, njegova se provedba ne može u potpunosti pratiti, niti se mogu vrednovati njegovi ishodi. Unatoč važnosti TPLJ-a, rijetka su istraživanja o njenim mjerenjima, uzrocima i posljedicama. Naš cilj je popuniti tu prazninu u literaturi istražujući: TPLJ u Hrvatskoj i Sloveniji, način na koji se ona mijenja tijekom vremena i razloge zbog kojih su neki lokalni proračuni transparentniji od drugih. Također ćemo nastojati odgovoriti na pitanja utječe li TPLJ na proračunske ishode u izbornim godinama, djeluje li na izborne rezultate i utječu li promjene TPLJ-a tijekom vremena na preferencije političara na vlasti i glasača u vezi s proračunskim ishodima. Oslanjajući se na postojeću literaturu i naše prijašnje radove, cilj nam je postaviti temelj za buduće istraživanje TPLJ-a, čiji će rezultat biti Indeks otvorenosti lokalnih proračuna (IOLP). Najprije ćemo uskladiti i prilagoditi već postojeću hrvatsku metodologiju (Ott, Bronić i Petrušić, 2013.; 2014.), kako bi se  mogla kontinuirano i na isti način primjenjivati na godišnjoj razini u Hrvatskoj i Sloveniji. Budući da će ovo  biti prvi put da se empirijski mjeri i prati TPLJ za prilično dugo razdoblje u dvije zemlje i budući da osim našeg rada (Ott, Bronić i Petrušić, 2013, 2014) nismo uspjeli naći niti jedan drugi rad o uzrocima i posljedicama TPLJ, naš kontinuirani projekt  će predstavljati jedinstven doprinos literaturi. Omogućit ćemo i donošenje boljih politika te veće sudjelovanje građana u odlučivanju o lokalnim proračunima. ]]></summary_hr><summary_en><![CDATA[Local government budget transparency (LBT) is of extreme importance as local authorities’ decisions upon spending public money have an impact on each and every citizen. LBT refers to how easily and to what extent citizens can access information on local government revenues and expenditures. Transparent budgets are a first step toward democratizing the budget process and giving citizens a say in policy formulation and resource allocation. A non-transparent budget cannot be properly analysed, its implementation cannot be thoroughly monitored nor can its outcomes be evaluated. Despite the importance of LBT, research into its measures, causes and consequences is thin. Our aim is to fill this literature gap and investigate: LBT in Croatia and Slovenia, how it changes over time and why some local budgets are more transparent than others. We will also try to answer: whether LBT affects budget outcomes in election years; whether it affects election outcomes and whether its changes over time influence incumbents&#39; and voters’ preferences regarding budget outcomes. Building upon the existing literature and our previous works, the aim is to construct the basis for future research into LBT, resulting in an open local budget index (OLBI). We will first harmonize and adapt the already existing Croatian methodology (Ott, Bronić and Petrušić, 2013; 2014) so that it can be further continually, annually applied in the same way in Croatia and Slovenia. Since this will be the first time that LBT will be empirically measured and monitored for a fairly long period of time in two countries, and since except for our own work (Ott, Bronić and Petrušić, 2013; 2014) we could find no other papers dealing with the causes and consequences of LBT, our continuous research will represent a unique contribution to the existing literature. Our results will also enable better policy-making and greater citizens’ participation in local budget deliberations.  ]]></summary_en></project><project>
<id>3853</id><title_hr><![CDATA[Ekonomske teškoće obitelji, psihosocijalni problemi i obrazovni ishodi adolescenata u vrijeme ekonomske krize]]></title_hr><title_en><![CDATA[]]></title_en><user_id>13038</user_id><user_firstLast_name>Marina Ajduković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-9088</code><acronim><![CDATA[FEHAP]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Socijalne djelatnosti, </scie_field_hr><scie_field_en>Social work, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Pravni fakultet u Zagrebu]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Law]]></institution_en><team_members_id>18962</team_members_id><team_members_names><![CDATA[ Doktorand: Ines Rezo ]]></team_members_names><keywords_hr><![CDATA[adolescenti,ekonomske teškoće obitelji,rizik siromaštva,eksternalizirani problemi,internalizirani problemi,rizična ponašanja,napuštanje školovanja]]></keywords_hr><keywords_en><![CDATA[adolescents, family economic hardship, risk of poverty, externalized problems, internalized problems, risk behaviours, dropping out of school]]></keywords_en><summary_hr><![CDATA[Cilj projekta je povećati razumijevanje učinaka ekonomskih teškoća obitelji na psihosocijalne i obrazovne probleme adolescenata u vrijeme nacionalne ekonomske krize. Novi integrativni model utjecaja ekonomskih poteškoća obitelji na razvoj adolescenta (IMEPO) će biti provjeren kroz longitudinalni kvantitativni i kvalitativni nacrt istraživanja. Istraživački problemi su: (1) Procijeniti ukupni i individualni doprinos prediktora u IMEPO na psihosocijalni razvoj adolescenata, gdje su kriteriji internalizirani i eksternalizirani problemi, druga rizična ponašanja (konzumacija alkohola i droga, kockanje i rizične seksualne aktivnosti) i obrazovni ishodi, uključujući napuštanje obrazovanja, (2) Usporediti uspješnost dva modela – osnovnog modela financijskog stresa (FSM) i novog IMEPO – u predviđanju psihosocijalnih i obrazovnih problema u razvoju mladića i djevojaka, (3) Utvrditi potencijalne rizične i zaštitne čimbenike koji moderiraju odnos između ekonomskih poteškoća obitelji i psihosocijalnih problema adolescenata te njihovih obrazovnih ishoda, (4) Ispitati promjene psihosocijalnih rizika i problema u školskom postignuću tijekom adolescencije, (5) Ispitati obrasce ranog napuštanja srednjoškolskog obrazovanja te steći dublje razumijevanje procesa i čimbenika koji vode ka napuštanju srednje škole.Učenike će se pratiti u tri točke mjerenja (I, II i III razred). Koristiti će se dvo-etapni neproporcionalno stratificirani klaster uzorak koji će obuhvatiti približno 1200 srednjoškolaca i njihovih majki/skrbnica. Istraživanje će se provesti u 6 županija središnje Hrvatske različitog ekonomskog statusa. Metodom namjernog uzorka bit će odabrano 40 učenika iz početnog uzorka koji su u promatranom razdoblju napustili srednjoškolsko obrazovanje. Ishodi projekta će se moći iskoristiti za daljnje razvijanje mjera socijalne i obiteljske politike usmjerenih prema smanjivanju negativnih učinaka ekonomskih teškoća na obitelji, obiteljske odnose i probleme prilagodbe adolescenata.]]></summary_hr><summary_en><![CDATA[Aim of the project is to advance the understanding of effects of family economic hardship on adolescents’ psychosocial and educational problems at a time of a nationwide economic crisis. A new integrative model of impact of family economic hardship (IMFEH) will be tested in a longitudinal quantitative and qualitative research design. The objectives are: (1) To assess the overall and individual contribution of predictors in IMFEH on adolescents&#39; psychosocial development, where internalized problems, externalized problems, other risk behaviours (alcohol and drug abuse, gambling, risk sexual behaviours) and educational outcomes, including dropp-out, will serve as criterion variables, (2) To compare the efficiency of two models – initial family stress model (FSM) and new IMFEH – in predicting psychosocial and educational problems in the development of male and female adolescents, (3) To identify potential risk and protective factors that moderate the relationship between family economic hardship and adolescents&#39; psychosocial problems and educational outcomes, (4) To investigate the changes in psychosocial risks and school achievement problems during adolescence, and (5) To explore patterns of early leaving secondary education and gain deeper understanding of the process and factors that lead to dropping out of secondary school. Pupils will be followed through 3 waves of data collection (1st, 2nd and 3rd grade). A two-stage disproportionally stratified cluster sample, which will include approximately 1200 pupils and their female caretakers, will be used. The research will be conducted in 6 counties that differ in economic development. 40 adolescents from the initial sample who have dropped out of school during the duration of the study will be recruited. The outcomes of the project will be used to advance the social and family policy measures aimed at reducing the negative effects of family economic hardship on family relations and adolescent adjustment problems.]]></summary_en></project><project>
<id>3858</id><title_hr><![CDATA[Napredna metodologija projektiranja prekidačkih istosmjernih pretvornika]]></title_hr><title_en><![CDATA[]]></title_en><user_id>7714</user_id><user_firstLast_name>Adrijan Barić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-6509</code><acronim><![CDATA[AdvaDCDC]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>22621</team_members_id><team_members_names><![CDATA[ Doktorand: Hrvoje Štimac ]]></team_members_names><keywords_hr><![CDATA[projektiranje integriranih sklopova, istosmjerni pretvornici, elektronički  sklopovi snage, galij-nitrid tranzistori, electromag. kompatibilnost]]></keywords_hr><keywords_en><![CDATA[integrated circuit design, DC-DC converters, power electronics, GaN transistors, electromagnetic compatibility]]></keywords_en><summary_hr><![CDATA[Napredna metodologija projektiranja prekidačkih istosmjernih pretvornika razvijena je u ovom projektu. Gornja sklopka, donja sklopa, pobudni i upravljački sklopovi integrirani su u jednom pakiranju, što minimizira utjecaj parazitnih elemenata i omogućava prekapčanja do 10 MHz. Razvit će se pobudni sklop s visokopreciznom kontrolom signala gornje i donje sklopke, što će omogućiti optimiranje mrtvog vremena s obzirom na efikasnost pretvaranja i smanjenje gubitaka za bilo koju kombinaciju parametara pakiranja integriranog sklopa, vanjskih komponenata i tiskane pločice. Posebna je pažnja posvećena projektiranju sklopa za pomak istosmjernog nivoa gornje sklopke. Osim što služi kao pobudni sklop za sklopke velike struje koje se nalaze na čipu, razvijeni pobudni sklop pobuđuje i vanjske pinove integriranog sklopa kako bi omogućio korištenje vanjskih sklopki. Galij-nitrid (GaN) i silicij-karbid (SiC) poluvodički elementi predstavljaju obećavajuće rješenje za visokonaponske i visokoefikasne pretvornike. Istosmjerni pretvornici koji koriste GaN/SiC tranzistore mogu se optimirati korištenjem prethodno razvijenog pobudnog sklopa. Razvijena metodologija omogućit će evaluaciju efikasnosti GaN i SiC elemenata u visokonaponskim prekidačkim primjenama kao i projektiranje kvalitetno optimiranih pretvornika. Tiskana pločica na koju je zalemljen čip pretvornika predstavlja sljedeći ključni dio dizajna pretvornika i ima dominantni utjecaj na određivanje elektromagnetske kompatibilnosti i termičkih svojstava pretvornika. Razvit će se simulacijsko okruženje koje omogućava elektromagnetsko-termičku kosimulaciju istosmjernih pretvornika. Provest će se statistička analiza parametara tiskane pločice i pakiranja integriranog sklopa kako bi se osiguralo da varijacije u proizvodnji ne narušavaju pouzdanost i efikasnost projektiranih pretvornika. ]]></summary_hr><summary_en><![CDATA[Advanced design methodology for switching DC-DC converters is developed. The low-side and high-side switch, their drivers and the control circuitry are integrated into one package which minimizes the parasitic elements and allows switching frequencies up to 10 MHz. A driving-signal circuitry with high-precision adjustable timings is developed. This will allow the optimisation of dead-times with respect to the power conversion efficiency of a converter for any given set of the parameters of the integrated circuit (IC) package, external components and a printed circuit board (PCB). A special attention is given to the design of a level-shifter for a high-side switch. Besides driving the on-chip power switches, the developed driving signal circuitry is routed to external pins of the IC package to enable driving of the externally connected switches. Gallium-nitride (GaN) and silicon-carbide (SiC) semiconductor devices present a promising solution for a high-voltage and high-efficiency power conversion. In order to design a highly efficient converter for high-voltage switching applications by using GaN and SiC power transistors, the GaN/SiC DC-DC converter will be optimised by using adjustable driving-signal circuitry, which is designed at the beginning of the project. The developed methodology will allow the evaluation of the efficiency of the GaN and SiC devices in high-voltage switching applications as well as highly optimised design of the converters. The PCB makes a large part of the design and it has a dominant effect in determination of the electromagnetic compatibility and thermal properties of the converter. A simulation environment which will allow the electromagnetic-thermal co-optimisation of DC-DC converters will be developed. A statistical analysis of the parameters of a PCB and an IC package will be performed to ensure that the variations in the manufacturing process do not compromise the reliability and the efficiency of the designed converters.]]></summary_en></project><project>
<id>3862</id><title_hr><![CDATA[Modeliranje toka podzemnih voda u krškim vodonosnicima]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6169</user_id><user_firstLast_name>Vedrana Kozulić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-2187</code><acronim><![CDATA[Karst modelling]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Građevinarstvo, </scie_field_hr><scie_field_en>Civil engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu Fakultet građevinarstva, arhitekture i geodezije]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Civil Engineering, Architecture and Geodesy]]></institution_en><team_members_id>21318</team_members_id><team_members_names><![CDATA[ Doktorand: Grgo Kamber ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[karst aquifers, groundwater flow modeling, multiresolution and multiscale approach, karst heterogeneity, distributive karst models]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Karst aquifers are very important groundwater resources around the world as well as in coastal part of Croatia. They consist of extremely complex structure defining by triple phases: slow porous medium, mostly laminar fractures and usually fast turbulent conduits/karst channels. Usually, karst aquifers have been analyzed by lumped hydrological models which ignore high heterogeneity of karst and consider only input (precipitation) and output (spring discharge) due to lack of extensive other input data and knowledge regarding the karst system. Last two decades full hydraulic (distributive) models have been developed exclusively by conventional finite elements considering karst heterogeneity structure that improves our understanding of complex processes in karst. Therefore, in this project we will develop novel “unique” flow model based on multi-resolution approach originally designed by Gotovac et al. (2007-2013) for 1-D and 2-D groundwater flow and transport simulations. Proposed approach is based on Fup basis functions with compact support and meshless collocation procedure enabling multi-scale representation of heterogeneity and other flow variables, closely related to the karst flow physical interpretation. Moreover, extending existing procedure to 3-D and constructing separate multi-scale solution for all three karst phases, proposed approach will enable the following impacts in comparison to conventional methods: desired spatial and temporal accuracy and high computational efficiency, modular model structure, incorporation of different heterogeneity scales related to existing measurements, enabling of transport and tracer test analysis and better understanding of karst aquifers due to solving of different engineering problems such as water usage and protection or contaminant pollution. Flow model will be verified by laboratory experiments and numerical synthetic benchmarks as well as real examples such as Jadro catchment and Ombla underground accumulation.]]></summary_en></project><project>
<id>3863</id><title_hr><![CDATA[Programski sustav za paralelnu analizu više heterogenih nizova vremenskih podataka s primjenom u biomedicini]]></title_hr><title_en><![CDATA[]]></title_en><user_id>18915</user_id><user_firstLast_name>Mario Cifrek</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-7975</code><acronim><![CDATA[]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>21274</team_members_id><team_members_names><![CDATA[ Doktorand: Krešimir Friganović ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>3864</id><title_hr><![CDATA[Subplate zona ljudskog mozga: neriješeni problemi]]></title_hr><title_en><![CDATA[]]></title_en><user_id>12951</user_id><user_firstLast_name>Ivica  Kostović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-2341</code><acronim><![CDATA[HUMANSUBPLATE]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Hrvatska akademija znanosti i umjetnosti]]></institution_hr><institution_en><![CDATA[Croatian Academy of Sciences and Arts]]></institution_en><team_members_id>22457</team_members_id><team_members_names><![CDATA[ Doktorand: Iris Žunić Išasegi  ]]></team_members_names><keywords_hr><![CDATA[subplate, prematurus, vulnerabilnost, moždana kora, razvitak]]></keywords_hr><keywords_en><![CDATA[subplate, preterm infant, vulnerability, cortex, development]]></keywords_en><summary_hr><![CDATA[Subplate zona je najistaknutiji i najvoluminozniji arhitektonski odjeljak stijenke telencefalona u mozgu čovjeka, s ključnom ulogom u razvoju neuronskih veza moždane kore. Istraživanja su pokazala da ta zona ima rano razvojno porijeklo, sadrži brojne sinapse i neurone složenih citoloških svojstava i molekularne raznovrsnosti, uključena je u razvoj aferentnih aksona iz talamusa, kao i uspostavu privremenih neuronskih veza, prolaznu ekspresiju neurotransmitera, neuronskih krugova moždane kore i njihovu funkcionalnu specifikaciju, evoluciju moždane kore te patogenezu neuroloških, kognitivnih i mentalnih poremećaja. Brojna pitanja bitna za humanu razvojnu neurobiologiju ostala su neriješena: Kako se subplate povećava tijekom trudnoće? Kakva je sublaminarna, sinaptička, neuronalna i glijalna organizacija? Kakva je uloga u migraciji neurona? Kakvi su odnosi subplatea s dugim asocijativnim kortiko-kortikalnim vezama? Kakva je postnatalna sudbina? Postoji li selektivna vulnerabilnost subplate neurona i različitih klasa aksona i kako to prikazati u in vivo MRI? Naša je hipoteza da će veličina, karakteristični neuralni sadržaj i produljeni razvitak zajedno s karakterističnim svojstvima na MRI omogućiti prikaz onih karakterističnih osobina ljudskog subplatea koje su povezane sa složenošću kortikalnih veza. Specifični ciljevi su određeni da odgovore na gore navedena pitanja, primjenom histoloških, imunocitokemijskih i in vitro, in utero te in vivo MRI tehnika u mozgu čovjeka, kao i usporedbom tih podataka s nalazima u majmuna tretiranih s H3-Thymidine markerom replikacije DNA (Rakic, Yale). Rezultati ovog projekta će omogućiti bolji uvid u razvitak osjetljivog mozga fetusa i prijevremeno rođene djece, proširiti normativne podatke za pedijatrijski neuroimaging i studije praćenja koje su usmjerene na razvoj kortikalnih veza, te omogućiti dobre polazne osnove za istraživanje neuroloških, kognitivnih i mentalnih poremećaja, koji imaju utjecaj na društvo. ]]></summary_hr><summary_en><![CDATA[Subplate zone is the most prominent and voluminous, connectivity related, compartment of the cerebral wall of developing primate brain playing different developmental roles. Studies of this enigmatic neuronal compartment in human brain and experimental models have demonstrated early origin, synapse-rich content, complex cytology and molecular diversity, involvement in growth of thalamo-cortical fibres, transient connectivity and transmitter expression, functional specificity, role in formation of cortical circuitry, evolutional significance and prospective role in pathogenesis of neurological, cognitive and mental disorders. Review of the current literature indicate gaps in the our knowledge and existence of unsolved problems regarding secondary expansion of subplate, sublaminar distribution of synapses and different phenotypes of migratory and postmigratory neurons, transformation of radial glia, pattern of growth of long associative cortico-cortical pathways and vulnerability of subplate (axons, neurons and glia in preterm infant). It is our hypothesis that size characteristic neuronal content and prolonged development, together with MR imaging properties, will facilitate demonstration of those characteristic features of the human (primate subplate), which are related to the complexity of cortical connectivity. In this project, we will use histological, immunocytochemical and MR imaging techniques (in vitro and in vivo) for developing human brain, as well as comparative analysis of experimental non-human primate (provided by dr. Rakic, Yale) in order to give answers for unsolved problems in human SP neurobiology. We expect to demonstrate characteristic features of the human subplate related to complex cortical connectivity, develop new diagnostic criteria for MR imaging and follow-up of perinatally damaged brain and define novel normative data necessary for study of developmental neurological, cognitive and mental disorders, which have severe impact on society.]]></summary_en></project><project>
<id>3865</id><title_hr><![CDATA[Razvoj naprednih visokonaponskih sustava primjenom novih informacijskih i komunikacijskih tehnologija]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5632</user_id><user_firstLast_name>IVO UGLEŠIĆ</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-5442</code><acronim><![CDATA[DAHVAT]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>23336</team_members_id><team_members_names><![CDATA[ Doktorand: Nina Stipetić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[high voltage, electric raliway, power quality, EMC, modelling, ICT]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The Research Project will develop the following implementation of new ICT technologies in High Voltage systems: 1. Application of new information and communication technologies such as lightning location system data for analysis of lightning overvoltages and overvoltage protection optimization:- Develop an original algorithm for lightning location data analyze in order to determinate the lightning flashes from the lightning strokes. - Analyze of collected lightning location date and develop an original algorithm for correlation with protection relay tripping in transmission and distribution lines. 2. Modeling the consumers with a big influence on the power quality in high voltage system- Influence of electric railway system on power quality in 110 kV transmission system.- Model of 25 kV 50 Hz electric railway system for power quality studies (electric locomotive, traction network, traction substation):- Compare the developed model with measurement results obtained on locomotives, electric trains and in electric traction substations.  3. New methods for the assessment of Electromagnetic Compatibility - Methodology for more precise electromagnetic influence calculation of contact line and electric traction system to the metal structure in the vicinity:- Identification and assessing the effect of changing values of model parameters based on the theory of electrical circuits to calculate the induced voltage.4. New models of components in studies of electromagnetic transients in high voltage systems- Development of wideband models for power system components (power and instrument transformers, circuit breakers, surge arresters, shunt reactors).- Summarize and analyze the detailed bibliography on the high frequency electromagnetic behavior of transformers (calculations and measurements). - High frequency transformer modeling.]]></summary_en></project><project>
<id>3867</id><title_hr><![CDATA[Reservoir Computing with Real-time data for future IT]]></title_hr><title_en><![CDATA[]]></title_en><user_id>24947</user_id><user_firstLast_name>Ivor Lončarić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-5449</code><acronim><![CDATA[]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>22602</team_members_id><team_members_names><![CDATA[ Doktorand: Mihovil Bosnar ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>3869</id><title_hr><![CDATA[Razvoj metodološkog okvira za rješavanje strateških problema u  visokom obrazovanju – primjer implementacije otvorenog učenja i učenja na daljinu]]></title_hr><title_en><![CDATA[]]></title_en><user_id>12531</user_id><user_firstLast_name>Vjeran Strahonja</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-1068</code><acronim><![CDATA[HigherDecision]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Informacijske znanosti, </scie_field_hr><scie_field_en>Information sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet organizacije i informatike]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Organization and Informatics]]></institution_en><team_members_id>25090</team_members_id><team_members_names><![CDATA[ Doktorand: Mišo Džeko ]]></team_members_names><keywords_hr><![CDATA[odlučivanje, e-učenje, otvoreno učenje i učenje na daljinu, visoko obrazovanje, e-spremnost, procjena rizika, kauzalnost, AHP]]></keywords_hr><keywords_en><![CDATA[decision making, e-learning, open and distant learning, higher education, e-readiness, risk assessment, portfolio, causality, AHP]]></keywords_en><summary_hr><![CDATA[Visoko obrazovanje (VO) ima ključnu ulogu u razvoju ljudskih potencijala te u gospodarskom i društvenom razvoju. Stoga, donošenje odluka i praćenje njihove primjene u visokom obrazovanju postaje prvorazredno istraživačko i razvojno pitanje. Primarni istraživački cilj ovog projekta je razvoj cjelovite metodologije donošenja strateške odluke i praćenja njezine provedbe u VO. U svijetu se broj korisnika online edukacije rapidno povećava, a postoje i brojna izvješća koja govore o digitalnoj spremnosti te upotrebi informacijsko-komunikacijske tehnologije (IKT) u VO. Dvije osnovne komponente projekta:1. Razvoj  metodološkog okvira donošenja strateških odluka u VO i praćenje njihove provedbe. 2. Primjena, prilagodba i provjera dane metodologije na primjeru implementacije odluke o uvođenju otvorenog učenja i učenja na daljinu.Istraživanje je interdisciplinarno i povezuje društveno područje (višekriterijsko odlučivanje, IKT, strateško planiranje) i matematiku (matematičko modeliranje, kvantitativne metode u odlučivanju, kauzalne modele i teoriju grafova). Istraživanje rješavanja strateških problema provodimo kroz ciklus strateškog odlučivanja u četiri faze: (1) prepoznavanje i istraživanje problema - identificirat će se i unaprijediti metodologije kao što su procjena spremnosti i difuzija inovacija.(2) razvoj metodologije odlučivanja i donošenja odluke -  istražit će se primjena i unapređenje metodologije višekriterijske analize odluka u VO.(3) provedba i praćenje strateške odluke - identificirati će se ključni faktori koji utječu na uspješnost provedbe strateške odluke i njihove međuzavisnosti i razviti model za mjerenje zrelosti i uspješnosti implementacije strateških odluka u VO.(4) evaluacija učinaka provedbe odluke -  istražit će se mogući pristupi, a posebno evaluacija upotrebom strukturalne teorije kauzalnosti. ]]></summary_hr><summary_en><![CDATA[Higher education’s (HE) key mission is to develop human potential with beneficial effects for the social and economic development. HE as a system, along with HE institutions, must be innovative and strategically managed to be able to fulfill their mission. Therefore, the decision making accompanied by evaluation of its implementation in higher education is an issue of highest priority. Primary goal of this research proposal is to develop a complete methodology for strategic decision making and the monitoring of its implementation in HE. The enrollment rate within online education has skyrocketed worldwide and there are a number of reports on e-readiness and ICT use in HE. Two basic components of the project:1. Development of methodological framework for strategic decision making in HE and monitoring of its implementation. 2. Application, adjustment and evaluation of the methodology on the example of decision implementation on e-learning and distance learning.This is an interdisciplinary project connecting Social Sciences (ICT, multicriteria decision making, strategic planning) and Mathematics (mathematical modeling, quantitative methods in decision making, structural causal models and graph theory).The research is structured as a cycle of strategic decision making with four phases:(1) Intelligence - problem identification and research, advancement of methodologies such as readiness assessment, diffusion of innovation etc.(2) Design of methodology -  design of decision making methodology and decision making, improvement of multicriteria decision analysis in HE.(3) Implementation and monitoring - research and identification of key factors that determine effectiveness of strategic decision, their correlation, design of measuring model for maturity and effectiveness of strategic decision implementation in HE(4) Evaluation - survey possible approaches and evaluation by application of J. Pearl’s structural causal models for identification of effects of strategic decision.]]></summary_en></project><project>
<id>3870</id><title_hr><![CDATA[Antički vodni sustavi grada Salone i Dioklecijanove palače i njihov utjecaj na održivost urbane sredine]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6669</user_id><user_firstLast_name>Jure Margeta</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-8974</code><acronim><![CDATA[RWSCSDP]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Građevinarstvo, </scie_field_hr><scie_field_en>Civil engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu Fakultet građevinarstva, arhitekture i geodezije]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Civil Engineering, Architecture and Geodesy]]></institution_en><team_members_id>21324</team_members_id><team_members_names><![CDATA[ Doktorand: Olgica Erceg ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Urban water system, Salona, Diocletian&#39;s palace, Aqueduct, Sewage]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The aim of the project is to study two Roman Water Systems which are using the same water source - Jadro spring. First one is Water System of Salona, capital of Roman province Dalmatia, from the 1st century, and the second one is of Diocletian&#39;s Palace in Split from 4th century. The study will consist of analysis and reconstruction of two, by its purpose, different Water System, one of typical urban character and another very specific of Emperor Palace. Unlike the Water System of the Palace, which is partly preserved (aqueduct is in function) and therefore more studied, the Water System of Salona is mostly unknown. They will be studied separately using the same methodology.All parts of Water Supply system will be studied: water intake on Jadro spring, route and elements of the aqueduct (channel, bridges and tunnels), water distribution tanks, lead pipe network and water appliances together with water quantity and quality issues. The study of sewage will consider wastewater and storm water drainage, as well as the protection from external surface water and groundwater. Besides those, methods, materials and techniques used by Roman engineers to establish efficient urban Water System indispensable for the life and health of the citizens will be analyzed and compared with modern system. The study will be based on collecting all data regarding explored elements of the Water System and on new archaeological excavations financed by this project. Existing topographic and architectonic surveys will be summarized and supplemented by new ones which will enable reconstruction of the whole system and elements. The project team is multidisciplinary and gathers civil engineers, architects and archaeologist. Apart from new knowledge about the planning, building and maintaining Roman Water Systems this project will give necessary data to protect elements of the system form devastation, to make a proper presentation and even to put some elements is use. ]]></summary_en></project><project>
<id>3871</id><title_hr><![CDATA[Upravljanje povjerenjem i koordinacija interakcija u pametnim mrežama ljudi, strojeva i organizacija]]></title_hr><title_en><![CDATA[]]></title_en><user_id>2602</user_id><user_firstLast_name>Vedran Podobnik</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-1777</code><acronim><![CDATA[SmartPMONetworks]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>22815</team_members_id><team_members_names><![CDATA[ Doktorand: Dario  Pevec ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[social networks, machine-to-machine communication, networked organizations, networked society, trust, coordination, context-awareness, big data]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[We live in a networked society where everything is connected. By 2020 there will be 8 billion people and 50 billion machines in the world and almost all of them will be connected through some kind of network. Furthermore, people and machines that share a certain collective goal will be grouped into some kind of organization, which again will be connected with other organizations and/or people/machines. In order to maintain sustainability of the networked society we need a framework and algorithms which will enable us to i) manage trust; and ii) coordinate interactions in such a complex eco-system consisting of thousands, millions or even billions of interconnected entities. Both the framework and algorithms should be scalable and robust (from the perspective of a network size and heterogeneity), support real-time dynamics (from the perspective of network interactions) as well as be applicable and analyzable at different levels of granularity (at a micro, mezzo and macro network levels). A possible solution for the framework is the “Smart Network”, where people/machines/organizations are represented as nodes which are described by profiles and build a network of connections. The “smartness” of “Smart Networks” stems from profiling nodes and realizing connections using automated computational methods, what is enabled by latest enhancements in information systems and state-of-the-art solutions in communication technologies. The “Smart Network” framework enables design of scalable, robust and real-time algorithms for managing trust and coordinating interactions because it can be i) formally operationalized as a graph where edges represent nodes and vertices represent connections; ii) functionally modeled as a multi-agent system where agents embody edges and relationships embody vertices; and iii) analyzed through complexity theory where sustainable solutions emerge as a result of a bottom-up modeling principle.]]></summary_en></project><project>
<id>3872</id><title_hr><![CDATA[Novi koncept primijenjene kognitivne robotike u kliničkoj neuroznanosti]]></title_hr><title_en><![CDATA[]]></title_en><user_id>7302</user_id><user_firstLast_name>Bojan Jerbić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-3073</code><acronim><![CDATA[ACRON]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, </scie_field_hr><scie_field_en>Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>22645</team_members_id><team_members_names><![CDATA[ Doktorand: Josip Vidaković ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[robotics, artificial intelligence, cognitive models, medicine, neuroscience]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The research in this project leads to novel forms and uses of cognitive robotics applied in clinical neuroscience. Robot’s performances during the surgical procedures are investigated within the previously conducted technological project, RONNA - Robotic Neurosurgical Navigation. Results of RONNA suggest that the benefits of using robots in the operating room are enormous, e.g. increased accuracy and repeatability of the surgical procedures, flexible and tremor free operations, etc. During the RONNA realisation, it is recognized that certain new cognitive robot skills yet need to be developed.The long-term vision of the proposed ACRON project as a multi-disciplinary research arises from the recognition that a paradigm shift in human-robot-environment interaction is needed. Currently, technology robustness is achieved by restricting the interaction space, so that the region and the nature of the interaction can be controlled by the system. In ACRON, the cognitive fulcrum will therefore move from sensed data to the robot contextual anticipation.ACRON will advance the research providing a uniform scientific framework for the study, development and implementation of cognitive concepts, providing the robot to function in ICT enabled ubiquitous environment that can be shared by different kinds of agents. ACRON will therefore bring the new context-aware medical robot capable to anticipate the most appropriate actions respecting the phase of the medical procedure and spatial positions of the staff and objects. We will investigate the relationship between people, robots and the shared environment where they interact and work together. By moving throughout the discretized working space and while achieving the current assignment, the medical robot will become able to avoid all-possible spatial collisions and make the appropriate context-based decisions.]]></summary_en></project><project>
<id>3873</id><title_hr><![CDATA[Procjena ponašanja konstrukcija u graničnim uvjetima rada]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3329</user_id><user_firstLast_name>Domagoj Lanc</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-5028</code><acronim><![CDATA[STRUBECON]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Temeljne tehničke znanosti, </scie_field_hr><scie_field_en>Basic engineering sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Tehnički fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Engineering]]></institution_en><team_members_id>23703</team_members_id><team_members_names><![CDATA[ Doktorand: Sandra Kvaternik ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[structures, material properties, experimental investigations, numerical investigations, limit state, assessment of structural behaviour]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Structures are designed according to their purpose taking into account all relevant service life requirements, which are usually related to a factor of safety, material properties, service life conditions and of course service life prediction. Structure may be sometimes exposed to unexpected conditions, let say adverse or hazard conditions. These conditions may cause failures making structure incapable to perform the function for which it has been designed. The task is to make an assessment of the structure behaviour at mentioned conditions and decide if the structure is capable for further operation. This means the assessment should provide an answer if the structure has sustained irreparable damage. Therefore, the main objective is to provide an assessment of structure behaviour, by comparing of the parameters like stress, strain, crack occurring, etc., caused by certain load level and temperature at this unexpected limit state with those allowed by material properties. To assess structural behaviour in operation at limit state, the following research sub-objectives should be accomplished: testing of material properties for the different environmental conditions; definition of impact energy as well as the determination of the crack driving force and life assessment of structural elements; evaluation of the semi-rigid structural joints/connections behaviour; development of a numerical algorithm for optimization of semi-rigid framed structures; creep buckling simulations of composite beam-type structures; proper constitutive modelling at limit operating conditions (i.e. plasticity, damage, thermomechanical coupling); application of new materials to be used at limit state – nanocomposites. Targeted structures are single and multi storey steel buildings, rigs, high-power electrical transmission towers, ship structures, etc.]]></summary_en></project><project>
<id>3874</id><title_hr><![CDATA[Višeskalno numeričko modeliranje deformiranja materijala od makro do nanorazine]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3311</user_id><user_firstLast_name>Zdenko Tonković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-3372</code><acronim><![CDATA[MNumMacroNano]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, </scie_field_hr><scie_field_en>Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>21241</team_members_id><team_members_names><![CDATA[ Doktorand: Karlo Seleš ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Engineering materials, bilogical tissues, multiscale modeling, finite element  method, meshless method, damage modeling, molecular dynamics]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Many engineering materials as well as biological tissues have a heterogeneous structure particularly when they are observed at microlevel. In order to assess structural integrity as well as to predict structural lifetime, an analysis at microlevel is required. In recent years, a special attention has been directed to the investigation of relations between macroscopic properties of materials and their microstructure as well as to perform a link to atomistic scale. Since classical continuum mechanics cannot consider structural effects in the material at the micro- and nanolevel, multiscale techniques are developed that model material deformation responses at multiple levels using appropriate numerical procedures. Deformation responses of arteries will be considered by using multiscale computational strategy too. A special attention will be directed toward the mathematical modeling of arterial growth and remodeling, which could help physicians to track certain cardiovascular diseases and predict their development. For modeling of engineering materials, a new micro-macro numerical procedure based on the second-order computational homogenization approach employing nonlocal continuum theory will be proposed. Both finite element and meshless spatial discretization will be applied. The damage evaluation at the microlevel which may lead to macroscopic fracture will be modeled. Here the damage evaluation law based on the computational averaging procedure will be used and the modeling at atomistic scale will be performed in the very narrow domain of localization. In the atomistic modeling using molecular dynamics, a special attention will be directed to the coupling of atomistic domain with the discretized continuum domain. An approach inspired by the quasicontinuum and bridging domain will be proposed. All results of the research will be tested by the modeling deformation responses of realistic materials.]]></summary_en></project><project>
<id>3875</id><title_hr><![CDATA[SPECTRESS - Social Performance, Cultural Trauma and the Reestablishing of Solid Sovereignties]]></title_hr><title_en><![CDATA[]]></title_en><user_id>12609</user_id><user_firstLast_name>Davor Dukić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-1353</code><acronim><![CDATA[]]></acronim><duration>01.01.2017 - 19.08.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filologija, </scie_field_hr><scie_field_en>Philology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>858310</team_members_id><team_members_names><![CDATA[ Doktorand: Marija Fiolić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>3876</id><title_hr><![CDATA[PRIMJENA CIJEVNIH PROPUSTA ZA POBOLJŠANJE KVALITETE MORA U LUKAMA/MARINAMA]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4885</user_id><user_firstLast_name>Dalibor Carević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-9770</code><acronim><![CDATA[EKO MARINA]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Građevinarstvo, </scie_field_hr><scie_field_en>Civil engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Građevinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Civil Engineering]]></institution_en><team_members_id>22817</team_members_id><team_members_names><![CDATA[ Doktorand: Damjan Bujak ]]></team_members_names><keywords_hr><![CDATA[cijevni propusti, izmjena mora, vrijeme zadržavanja, cirkulacija u luci, eko marina]]></keywords_hr><keywords_en><![CDATA[flushing culverts, residence time, flushing time, sea exchange, eko marina]]></keywords_en><summary_hr><![CDATA[Ovaj projekt donosi zaključke o mjerama koje trebaju biti primijenjene u svrhu osiguranja dovoljne izmjene vode u budućim lukama upotrebom cijevnih propusta. Ugradnja cijevnih propusta u konstrukciju lukobrana je najjeftinija metoda, između ostalih. Svrha cijevnih propusta je da omoguće izmjenu vode između otvorenog mora i mora zatvorenog u luci. Generalno postoji manjak znanja koji bi opisivao funkcioniranje cijevnih propusta kao instrumenta za izmjenjivanje vode. Slijedeća pitanja trebaju biti odgovorena kroz faze ovoga projekta: 1. FAZA I: Koja se veličina protoka ostvaruje u propustima pod djelovanjem vjetrovnih valova, i kolika je vrijednost transmitirane valne energije? Metodologija: Fizikalni model u laboratoriju (u valnom kanalu) sa modelom cijevnih propusta. 2. FAZA II: Funkcioniranje cijevnih propusta u realnim uvjetima (u stvarnoj luci), što znači, složeni uvjeti istovremenog djelovanja valova s vanjske strane luke zajedno sa plimnim oscilacijama i vjetrovnom cirkulacijom mora (koji je protok u propustima u takvim uvjetima?). Metodologija: Sveobuhvatna terenska mjerenja u marini Ičići (Opatija) u svrhu kalibracije 3D numeričkog modela. 3. FAZA III: Koliko pozija propusta u tijelu lukobrana doprinosi protoku u propustima? Metodologija: 3D numeričko modeliranje.Općenita svrha istraživanja je razotkriti funkcioniranje cijevnih propusta korištenjem laboratorijskih modela, terenskih istraživanja i numeričkog modeliranja. Rezultat istraživanja će biti inženjerske preporuke i jednostavni matematički modeli (jednadžbe, grafovi) koji će pomoći inženjerima u optimalnom projektiranju cijevnih propusta.]]></summary_hr><summary_en><![CDATA[This project provide conclusions on measures that need to be implemented in order to secure enough exchange of water mass in future harbors using flushing culverts (pipes). Installation of flushing culverts inside the breakwater structure is the most cost-effective method, among others. The purpose of culverts is to enable the exchange of the open sea water and the water contained within a protected maritime zone. There is a general lack in research that would provide an explanation on how pipe culverts actually work as a sea water exchange instrument. The next answers should be reached through phases of this project. 1. PHASE I: What is the amount of water discharge in culverts under the agency of surface wind waves, and what is the amount of wave energy transmission?. Methodology: Physical model in laboratory (wave channel) with flushing culverts model. 2. PHASE II: Functioning of flushing culverts in a realistic conditions (in real harbor), which means, the complex conditions of simultaneous actions of waves coming from outside a harbor along with tidal oscillations and wind driven circulation of sea (what is the water discharge in culverts in such conditions?). Methodology: Extensive field measurements in Ičići marina (Opatija) with purpose on calibration of 3D numerical model . 3. PHASE III: How much does positions of culverts in breakwater’s body contributes to the culverts discharge? Methodology: 3D numerical modelling. The overall purpose of the research is to discover flushing culverts functioning using laboratory models, field measurements and numerical modelling The result of the research would be engineering guides and simple mathematical models (equations, graphs) that would help engineers in optimal design of the flushing culverts. ]]></summary_en></project><project>
<id>3877</id><title_hr><![CDATA[Market uptake of small modular renewable district heating and cooling grids for communities (CoolHeating)]]></title_hr><title_en><![CDATA[]]></title_en><user_id>13012</user_id><user_firstLast_name>Neven Duić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-1739</code><acronim><![CDATA[]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, </scie_field_hr><scie_field_en>Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>22648</team_members_id><team_members_names><![CDATA[ Doktorand: Matija Pavičević ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>3878</id><title_hr><![CDATA[Wrist and arm sensing technologies for cardiac arrhythmias detection]]></title_hr><title_en><![CDATA[]]></title_en><user_id>18917</user_id><user_firstLast_name>Ratko Magjarević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-1132</code><acronim><![CDATA[]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>25143</team_members_id><team_members_names><![CDATA[ Doktorand: Dominik Džaja ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>3883</id><title_hr><![CDATA[Ispitivanje reaktivnosti trombocita u različitim srčanožilnim bolestima]]></title_hr><title_en><![CDATA[]]></title_en><user_id>7462</user_id><user_firstLast_name>Davor  Miličić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-3918</code><acronim><![CDATA[SPARELIFE-CVD]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Clinical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>21231</team_members_id><team_members_names><![CDATA[ Doktorand: Saša Pavasović ]]></team_members_names><keywords_hr><![CDATA[kardiovaskularne bolesti, reaktivnost trombocita, agregometrija, personalizirana kardiologija, klinički ishodi]]></keywords_hr><keywords_en><![CDATA[cardiovascular diseases, platelet reactivity, aggregometry, personalized cardiology, clinical outcomes]]></keywords_en><summary_hr><![CDATA[Predloženi projekt je nastavak dosadašnjeg rada u kojem se nastoji ispitati značaj reaktivnosti trombocita u različitim srčanožilnim oboljenjima te mogućnost da se individualiziranom primjenom antitrombocitnih lijekova prema vrijednostima reaktivnosti trombocita poboljšaju klinički ishodi. Istraživanje je podijeljeno u pet cjelina koje će se paralelno provoditi. Prva cjelina obuhvaća nastavak istraživanja utjecaja povišene ostatne reaktivnosti trombocita i individualiziranog pristupa primjene antitrombocitne terapije u bolesnika s akutnim koronarnim sindromom. Druga cjelina će istraživati promjene reaktivnosti trombocita kod bolesnika nakon izvanbolničkog aresta koji se podvrgavaju protokolu terapijske hipotermije. Nedovoljno je istraženo kako kontrolirano snižena tjelesna temperatura utječe na agregacijsku kaskadu in vivo, osobito u bolesnika koji se liječe antitrombocitnim lijekovima. Treća cjelina će obuhvatiti bolesnike koji se liječe mehaničkom cirkulacijskom potporom zbog terminalne faze srčanog popuštanja. U toj skupini evaluirat ćemo reaktivnost trombocita povezanu s korištenjem izvantjelesnog krvotoka odnosno mehaničkih srčanih crpki i povezanost s trombozama uređaja i s krvarenjima. U četvrtoj cjelini istraživat ćemo ulogu funkcije trombocita u sekundarnoj plućnoj hipertenziji uzrokovanoj bolešću miokarda lijeve klijetke (WHO tip II). Povezanost reaktivnosti trombocita i težine bolesti je već pokazana u primarnoj plućnoj hipertenziji, ali ne i u mnogo češćoj, plućnoj hipertenziji tipa II. Rezultati bi mogli pridonijeti poznavanju patofiziologije sekundarne plućne hipertenzije tipa II s mogućim terapijskim implikacijama, jer se namjerava ispitati, moduliraju li promjene reaktivnosti trombocita vazoaktivni odgovor na prostaglandin E1. Posljednja, peta cjelina će biti posvećena ispitivanju prognostičkog značenja reaktivnosti trombocita na razvoj koronarne vaskulopatije u bolesnika nakon presadbe srca što do sada nije istraživano.]]></summary_hr><summary_en><![CDATA[The proposed project represents a continuation of our previous work which will examine the significance of platelet reactivity (PR) in a variety of cardiovascular diseases and the potential of individualized approach in antiplatelet therapy regimen based on the values of PR to improve clinical outcomes. The research will be divided into five arms that will be conducted simultaneously. The first arm will be the continuation of our research on the impact of high on-treatment platelet reactivity and individualized approach to the application of antiplatelet therapy in patients with acute coronary syndrome. The second arm will study the changes of PR in patients with out-of-hospital cardiac arrest who undergo therapeutic hypothermia protocol. It is insufficiently explored how a controlled low body temperature affects the aggregation cascade in vivo, particularly in patients treated with antiplatelet drugs. The third arm will include patients with implanted mechanical circulatory support (MCS) due to end-stage heart failure. In this group we will evaluate the association of PR levels in patients with MCS and device thromboses as well as bleeding events. In the fourth study arm we will investigate the role of platelet function in secondary pulmonary hypertension caused by left ventricular myocardial disease (WHO type II). Correlation between PR and the severity of the disease has been shown in primary pulmonary hypertension, but not in much more frequent, type II pulmonary hypertension. The results might contribute to the knowledge of the pathophysiology of pulmonary hypertension, with potential therapeutic implications as we intend to examine whether the changes in PR modulate the response to vasoactive prostaglandin E1. The last, fifth arm will be devoted to heart transplant patients where we will examine the prognostic significance of PR in the development of coronary vasculopathy after heart transplantation which has not been investigated so far.]]></summary_en></project><project>
<id>3885</id><title_hr><![CDATA[Profesionalne aspiracije prema STEM zanimanjima tijekom osnovne škole: longitudinalno istraživanje odnosa postignuća, vjerovanja o vlastitim kompetencijama i interesa za zanimanja]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6293</user_id><user_firstLast_name>Toni Babarović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-3999</code><acronim><![CDATA[JOBSTEM]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Psihologija, </scie_field_hr><scie_field_en>Psychology, </scie_field_en><institution_hr><![CDATA[Institut društvenih znanosti Ivo Pilar]]></institution_hr><institution_en><![CDATA[Institute of Social Sciences Ivo Pilar in Zagreb]]></institution_en><team_members_id>21321</team_members_id><team_members_names><![CDATA[ Doktorand: Mara Šimunović ]]></team_members_names><keywords_hr><![CDATA[STEM područje, odabir zanimanja, školska postignuća, pojam o sebi, longitudinalna istraživanja, učinci intervencija]]></keywords_hr><keywords_en><![CDATA[STEM, vocational interest, school achievement, self-concept, self-competence beliefs, longitudinal studies, effectiveness of interventions]]></keywords_en><summary_hr><![CDATA[U globaliziranom, brzo mijenjajućem svijetu, pitanja obrazovnog postignuća i aspiracija mladih prema pojedinim zanimanjima od izuzetnog su značaja. To se posebno odnosi na zanimanja u području znanosti, tehnologije, inženjerstva i matematike (STEM), tehnološki sofisticiranim i inovativnim zanimanjima važnim za društveni razvoj. Od devedesetih na ovamo naklonost mladih upravo za takva zanimanja stalno opada. Istraživači, nositelji politika i institucije poput EU suočeni su s jasnim podacima o evidentnom nedostatku studenata u STEM programima te nedostatku pojedinih STEM stručnjaka.Predloženi projekt temelji se na suvremenim teorijama akademskog postignuća, vjerovanja o vlastitoj kompetenciji u akademskoj domeni i interesa za zanimanja te je strukturiran oko tri glavna istraživačka cilja: (i) ispitati kako se kod učenika opći i specifični interesi za STEM zanimanja stvaraju te mijenjaju li se tijekom vremena; (ii) ispitati odnos školskog postignuća učenika i vjerovanja o vlastitoj kompetenciji s općim i specifičnim interesima za STEM zanimanja, te testirati da li se obrazac tih odnosa mijenja tijekom osnovnoškolskog obrazovanja; (iii) ispitati kako obitelji i spol/rod oblikuju opće i specifične interese učenika vezane uz STEM karijere.Projekt se temelji na longitudinalno-sekvencijalnom istraživačkom nacrtu, složenom metodološkom okviru koji dozvoljava sagledavanje ovakvih istraživačkih pitanja. Ukupno će biti praćeno 1920 učenika osnovnih škola i njihovih roditelja/staratelja, podijeljenih u tri dobne kohorte, koje će se longitudinalno ispitivati kroz tri vala mjerenja. Dodatni je cilj projekta implementirati STEM intervencijski program u osnovne škole te sagledati njegove učinke u kontekstu STEM zanimanja, gdje će se koristiti esperimentalni nacrt s testiranjem prije i nakon tretmana u dvije skupine. Očekujemo da će sve poduzete aktivosti povećati sadašnja znanja, biti poticajne drugim istraživačima, a stečeno znanje korisno učenicima, učiteljima i donositeljima odluka.]]></summary_hr><summary_en><![CDATA[In the globalized and rapidly changing world, the issues of young people’s educational achievement and career aspirations are extremely important. These issues are especially relevant in vocations in the fields of Science, Technology, Engineering and Mathematics (STEM), which are technologically sophisticated and important for the development of the society. Since 1990s the interest of youth for these vocations is declining. Researchers, national governments and authorities like EU operate with exact figures which clearly demonstrate a shortage of STEM graduates and a decline in number of STEM experts.  The proposed project is grounded in contemporary theories of academic achievement, self-competence beliefs and vocational interests and it is structured around three main research goals: (i) to examine how students’ general and specific STEM career aspirations are formed and how they change over time; (ii) to examine how students’ academic achievement and self-competence beliefs are related to their general and specific STEM career aspirations and how the pattern of relations among them changes during the course of primary schooling; (iii) to examine how students’ general and specific STEM career aspirations are shaped by their families and gender. The project is based on a longitudinal research design, as a suitable methodological framework for responding to these complex research questions. A total of 1920 primary school students and their parents/guardians will participate in the study. Students will be grouped in three age cohorts, which will be followed longitudinally through three measurement waves. The additional goal of the project is to implement a STEM intervention program in primary schools and evaluate its’ effects by using two-group pre- and post-test randomized experimental design. The project is intended to create new knowledge useful for researchers, students, teachers as well to create knowledge-based implications for relevant stakeholders.]]></summary_en></project><project>
<id>3889</id><title_hr><![CDATA[Enzimi purinskog reciklirajućeg ciklusa iz Helicobacter pylori i Escherichie coli ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>690</user_id><user_firstLast_name>Ivana Leščić Ašler</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-2664</code><acronim><![CDATA[PSPE]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>23182</team_members_id><team_members_names><![CDATA[ Doktorand: Ante Bubić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Purine metabolism, enzyme inhibiton, drug design, H. pylori, E. coli, crystal structure, analytical biochemistry, H/D exchange, susceptibility testing]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The main goal of the proposed project is to identify new drug targets and accordingly design, prepare and characterise new drugs for Helicobacter pylori eradication. Helicobacter pylori is a bacterium that colonizes one half of the world population and it is regarded as one of the most invasive human pathogens responsible for development of many diseases. There are two possible pathways that organisms can use to synthesize purines as indispensable building blocks for DNA and RNA synthesis. However, bacterium H. pylori  uses the salvage pathway, only. Therefore, we plan to disable H. pylori growth and replication by inhibiting the key enzymes, purine nucleoside phosphorylase and adenylosuccinate synthetase, on this pathway.The proposed project includes the interdisciplinary team with expertise in the research areas of molecular biology and genetics, biochemistry and biophysics, macromolecular crystallography, biological mass spectrometry, molecular modelling, organic synthesis, analytical ultracentrifugation methods, susceptibility testing, and managing ‘big data’ through data integration (extracted from various databases). All equipment necessary to accomplish the proposed research is available in the host institution (Rudjer Bošković Institute) except for analytical ultracentrifuge available by foreign co-worker A. Bzowska (Warsaw, Poland).]]></summary_en></project><project>
<id>3893</id><title_hr><![CDATA[Patofiziološke posljedice promjene sastava lipidnih splavi (Raft Tuning)]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4409</user_id><user_firstLast_name>Marija Heffer</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-7725</code><acronim><![CDATA[]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Medicinski fakultet Osijek]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Medicine]]></institution_en><team_members_id>22754</team_members_id><team_members_names><![CDATA[ Doktorand: Milorad Zjalić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>3894</id><title_hr><![CDATA[Iznad Nyquistove granice]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6982</user_id><user_firstLast_name>Damir Seršić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-1316</code><acronim><![CDATA[BeyondLimit]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>22636</team_members_id><team_members_names><![CDATA[ Doktorand: Ivan Ralašić ]]></team_members_names><keywords_hr><![CDATA[pod-Nyquistovsko uzorkovanje, sažimajuće očitavanje, kauzalni splajnovi, rijetke reprezentacije, adaptivni valići, napredni dizajn sustava]]></keywords_hr><keywords_en><![CDATA[sub-Nyquist sampling, compressive sensing, causal splines, sparse representations, adaptive wavelets, advanced system design]]></keywords_en><summary_hr><![CDATA[Moderne informacijske i komunikacijske tehnologije suočene su s nizom izazova. Među njima izdvojili smo dva važna: ogromnu količinu podataka koja dolazi iz realnog svijeta putem senzora, kao i snagu računala potrebnu za njihovu obradu. U ovom projektnom prijedlogu smo se usmjerili na oba navedena izazova, kao i na napredne primjene ponuđenih rješenja.Desetljećima, Nyquistova granica postavlja doseg rada digitalnih elektroničkih sustava koji djeluju u analognom svijetu. Korištenjem našeg prethodnog istraživanja u području kauzalnih splajnova, adaptivnih valića, rijetkih reprezentacija te naprednog dizajna sustava, razvit ćemo originalni sustav koji radi iznad Nyquistove granice. Pod-Nyquistovsko uzorkovanje u uniji analognih potprostora te sažimajuće očitavanje su područja istraživanja korištena za postizanje ovog cilja. Obje tehnike rezultiraju aplikacijama koje idu preko poznatih granica: rezultiraju u novim tehnikama prikupljanja i obrade slika, naprednim radarskim i sonarskim uređajima, širokopojasnom programski definiranom radiju, kao i naprednim sustavima za obradu govornih i audio signala. Oslanjaju se na rijetke reprezentacije signala, sofisticiranu rekonstrukciju i algoritme za obradu signala, kao i na inteligentne implementacije koje kombiniraju analogne i digitalne podsustave.Istraživači okupljeni u ovom projektnom timu imaju iskustvo u modeliranju rijetkim signalima, dizajnu naprednih analognih i digitalnih sustava, a razvili su i različite aplikacije u obradi slika, audio i govornih signala. Razvit ćemo originalan sustav iznad Nyquistove granice zasnovan na našim kauzalnim splajnovima. Koristit ćemo naše adaptivne sustave i brze L1 minimizacijske algoritme radi postizanja rijetkih reprezentacija potrebnih u sažimajućem očitavanju. Rezultati će se koristiti u dizajnu novog pod-Nyquistovog sustava, čija će se realizacija oslanjati na naš napredni dizajn. Razvit ćemo aplikacije u obradi 3D signala, slika te obradi audio i govornih signala.]]></summary_hr><summary_en><![CDATA[Modern information and communication technologies face various challenges. We identified two of them as important: huge amount of data delivered from the real world via sensing devices, and computing power required for its processing. Both challenges are targeted in our project proposal, as well as some advanced applications of the proposed solutions.For decades, Nyquist limit sets the achievable work range of digital electronic systems operating in an analogue world. Using our previous research and expertise in causal splines, adaptive wavelets, sparse representations, and advanced system design, we will develop an original system that works beyond the Nyquist limit. Sub-Nyquist sampling in a union of analogue subspaces and compressive sensing are research topics used to achieve this goal. Both approaches result in applications that go beyond the known limits: they result in novel imaging techniques, advanced radar and sonar devices, wide-band software defined radios, as well as in advanced speech and audio processing systems. They rely on sparse representation of signals, sophisticated reconstruction and signal processing algorithms, as well as on intelligent hardware implementations that mix analogue and digital subsystems. The researchers gathered in this project team have research experience in causal splines, adaptive wavelets and sparse signal modeling, as well as in design of advanced analogue and digital systems. They have developed various applications in image, audio and speech signal processing. We will develop an original beyond Nyquist system based on our causal splines. We will use our adaptive systems and fast L1 minimization algorithms to achieve sparse representations needed in compressive sensing. The results will be used in design of novel sub-Nyquist systems, whose realization will rely on our advanced system design. We will develop its applications in 3D, image, audio and speech signal processing.]]></summary_en></project><project>
<id>3895</id><title_hr><![CDATA[Mjeriteljska infrastruktura za pametne mreže]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5372</user_id><user_firstLast_name>Roman Malarić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-9707</code><acronim><![CDATA[SMAGRIMET]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>21317</team_members_id><team_members_names><![CDATA[ Doktorand: Jure Konjevod ]]></team_members_names><keywords_hr><![CDATA[Pametne mreže, mjeriteljstvo, precizne mjerne metode, mjerenje snage, mjerenje energije]]></keywords_hr><keywords_en><![CDATA[Smart grid, metrology, precise measurement methods, measurement of power, measurement of energy]]></keywords_en><summary_hr><![CDATA[Cilj ovog projekta je izgradnja nacionalne mjeriteljske infrastrukture za podršku Smart Grid tehnologiji, koja u potpunosti nedostaje u trenutnoj hrvatskoj mjeriteljskoj infrastrukturi. Nedostaje čak i nacionalni etalon za snagu i energiju. SMAGRIMET će biti glavni centar za istraživanje i razvoj potrebne mjeriteljske infrastrukture u Republici Hrvatskoj za smart grid i srodna znanstvena područja koji će učinkovito premostiti jaz između hrvatske i europske mjeriteljske infrastrukture. Većina europskih mjeriteljskih instituta sudjelovala je u projektu razvoja Smart Grid mjeriteljske infrastrukture u kojem Hrvatska nije sudjelovala zbog nedostatka infrastrukture za mjerenje snage i energije i povezanih istraživanja vezana za pametne mreže. Istraživanje u ovom projektu će biti usmjereno na razvoj vrlo preciznih naponskih i strujnih mjernih pretvornika, pomoću analogno digitalnih pretvornika i koristeći nove algoritme za preciznu analizu mjernih podataka. Ovaj istraživački projekt će adresirati niz mjeriteljskih izazova koji će pružiti neophodnu podršku kako bi se osigurala sigurnost opskrbe električnom energijom i stabilnost mreže. Izazovi su mnogi: Mjerni okvir za nadzor i stabilnost pametne mreže, sljedivost mjerenja na udaljenim lokacijama energetske infrastrukture koji osiguravaju pravednu trgovinu energijom, daljinsko mjerenje u energetskim postrojenjima i kućanstvima, kvalitetu i učinkovitost energije te modeliranje, simulacija i analiza stanja pametne mreže. Također, uvođenje novog standarda IEC 61850 će promijeniti način na koji će trafostanica funkcionirati u budućnosti, a novi izazovi i rješenja tek trebaju biti istraženi i razvijeni. ]]></summary_hr><summary_en><![CDATA[The aim of this project is to build national metrology infrastructure to support smart grid technology and research, as it is completely lacking in the current Croatian metrology infrastructure. Even, the power and energy national standard is missing.The SMAGRIMET will be main centre for research and development of necessary metrological infrastructure in Croatia for smart grid and related scientific fields that will effectively bridge the gap between the Croatian metrological infrastructure and European counterparts. Most of the European metrological institutes have contributed to the European Smart grid metrology project in which Croatia has not taken part because of the lack of infrastructure for measuring power and energy and related issues related to smart grids.The research will be focused in developing highly accurate voltage and current transducers, using precision sampling devices and using new algorithms to accurately analyse measurement data.This research project addresses a series of metrological challenges that will provide essential support to ensure security of electricity supply and grid stability, grid quality, and fair trade between commercial parties employing the grid. The challenges are many: Measurement framework for monitoring stability of smart grids, traceable on-site energy measurement systems for ensuring fair energy trade, remote on-site measurement of power quality and efficiency and modelling, simulation and network analysis of the system state of smart grids-. Also the introduction of the new standard IEC 61850 will change the way the substation will function in the future. The standard makes new challenges and solutions have yet to be researched and developed.]]></summary_en></project><project>
<id>3898</id><title_hr><![CDATA[Histološka, MRI i analiza genske ekspresije reorganizacijskih procesa u medijalnom (limbičkom) zidu ljudskog mozga tijekom razvitka]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6256</user_id><user_firstLast_name>Nataša Jovanov Milošević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-3939</code><acronim><![CDATA[MEDCEREB]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>22600</team_members_id><team_members_names><![CDATA[ Doktorand: MIHAELA BOBIĆ ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[subplate, marginal zone, human brain development, immunohistochemistry, gene expression, in situ hybridization, MRI analysis, hippocampus, cingulum]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The salient feature of the human fetal cortex is the presence of the subplate zone (SP), a prominent, synapse rich compartment composed of „waiting“ afferents, loosely arranged axons, synapses, growth cones, migratory neurons, glial cells and extraordinary amount of extracellular matric molecules (ECM). The medial (limbic) cortical regions (areas involved in emotion and memory functions) develop a different laminar structure in comparison with lateral cortical regions. Unlike the lateral cortex, where the SP is a major site of neurogenetic events, in the medial archicortex marginal zone (MZ) seems to be a key zone for early molecular neuronal interactions, synaptogenesis and patterning of growing pathways. The goal of this project is to correlate developmental reorganization of major cellular (cell bodies, growing axons) components of the SP and the MZ in developing medial wall of the human cerebrum (cingulum, hippocampus, amygdala) by combining immunochistochemistry, in situ hybridization, transcriptome analysis with in vivo/in vitro MRI. Histological analysis wiil be performed on postmortem human brains, ranging from 10 postconceptional weeks (POW) to 6.5 years, to analyze the expression patterns of different developmentally regulated proteins in relation to synaptic, laminar, neuronal, glial and ECM development. These results will be correlated with in vivo/in vitro MRI findings obtained in age-matched fetuses, infants and children. In addition, we will also analyze publicly available gene expression database (Kang et al., 2011) to investigate the relationship between structural changes and spatio-temporal expression of specific candidate genes. For the selected candidate genes we will perform in situ hybridization and immunocytochemistry in order to elucidate in which cells are these genes expressed. The obtained data will be used for setting the baseline for studying developmental abnormalities characteristic for diverse neurological disorders]]></summary_en></project><project>
<id>3899</id><title_hr><![CDATA[Logika, pojmovi i komunikacija]]></title_hr><title_en><![CDATA[]]></title_en><user_id>91</user_id><user_firstLast_name>Srećko Kovač</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-9955</code><acronim><![CDATA[LogiCCom]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filozofija, </scie_field_hr><scie_field_en>Philosophy, </scie_field_en><institution_hr><![CDATA[Institut za filozofiju]]></institution_hr><institution_en><![CDATA[Institute for Philosophy in Zagreb]]></institution_en><team_members_id>13057</team_members_id><team_members_names><![CDATA[ Doktorand: Ivan Restović ]]></team_members_names><keywords_hr><![CDATA[logika, pojam, ontologija, znanje, pragmatika, Kant, Bolzano, Frege]]></keywords_hr><keywords_en><![CDATA[logic, concept, ontology, knowledge, pragmatics, Kant, Bolzano, Frege]]></keywords_en><summary_hr><![CDATA[Cilj je projekta reafirmacija temeljne uloge pojmova kao intenzija u logici kao i formalne pragmatike porabe pojmova u zaključivanju. Taj se cilj želi postići  istraživanjem koje na unutrašnji način povezuje intenzionalni i pragmatički pristup logici.Istraživanje ima četiri glavna aspekta unutar kojih se želi pokazati osnovna uloga pojmova: logika pojmova, pojmovni temelji ontologije, pojmovni temelji znanja i  društvena pragmatika pojmova.1) Istražit će se intenzionalna narav pojmova kao osnovanih na logičkim radnjama apstraktnih činitelja koji zaključuju (apstraktna pragmatika). Ispitat će se moguće intenzionalno podrijetlo klasičnih logičkih zakona. Pojmovima će se pristupiti  sa stajlišta logike prvoga reda i teorije tipova. Želi se ispitati hipoteza prema kojoj se intenzionalna logika i logički pojmovi mogu opisati pomoću pojmova objektivnosti i (prema Gödelovoj hipotezi)  uzročnosti.2) Ispitat će se intenzionalna bit temeljnih ontologijskih pojmova na primjeru  formalizacije Bolzanove ontologijske teorije, u usporedbi s Leibnizovom ontologijom. Istraživanje će se usredotočiti na pojmove supstancije, adherencije/inherencije i cjelina-dio.3) Želi se pokazati doprinos pojmova objektivnoj vrijednosti znanja, osobito  u  matematici, i u oslonu na Fregeovu teoriju pojmova. Posebno će se istraživati međuodnos pojmovnoga i predmetnoga sadržaja u analitičnim iskazima i iskazima prvoga reda.4) Analizirat će se uzročna uloga logičkih pojmova i jezika u kontekstu njihove porabe u govornim činovima i argumentacijskome dijalogu. Pokazat će se da je pragmatika bitna sastavnica logike, te da se, kao i sintaksa i semantika, može rigorozno formalizirati. Ktomu, istraživanje želi pokazati da je uporaba logike i jezika primarni izvor opisa pojmova.]]></summary_hr><summary_en><![CDATA[The project aims at re-establishing the fundamental role of concepts as intensions in logic as well as of formal pragmatics of the use of concepts in reasoning. This aim is to be achieved by means of the research that will intrinsically interconnect the intensional and pragmatic approach to logic. The research has four main aspects within which the basic role of concepts is aimed to be shown: logic of concepts, conceptual foundations of ontology, conceptual foundations of knowledge, and social pragmatics of concepts.1) The intensional nature of concepts will be investigated as based on logical operations of abstract reasoning agents (abstract pragmatics). A possible intensional origin of classical logical laws will be examined. Concepts will be approached in first-order and type-theoretical setting as well. One hypothesis to be examined is that intensional logic and logical concepts can be described in terms of objectivity and (according to Gödel’s hypothesis) in terms of causality.2) The intensional nature of some fundamental ontological concepts will be examined on the example of the new formalization of Bolzano’s ontological theory, in comparison Leibniz&#39;s  ontology. The research will focus on the concepts of substance, adherence/inherence, and whole-part.3) The contribution of concepts to the objective value of knowledge is aimed to be shown, especially in mathematics, and starting from Frege’s theory of concepts. Especially, the interrelationship of the conceptual and objectual content in analytic and first-order propositions will be investigated.4) The causal role of logical concepts and language in the context of their use in speech acts and argumentative dialogue will be analysed. Pragmatics will be shown to be an essential constituent part of logic, which is, like syntax and semantics, apt to be rigorously formalized. In addition, the research aims to show that the use of logic and language is a primary source of the description of concepts.]]></summary_en></project><project>
<id>3902</id><title_hr><![CDATA[Poluvodički elementi visokih performansi  za primjene u sklopovima za bežične komunikacije i optičke detektore]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6955</user_id><user_firstLast_name>Tomislav Suligoj</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-6924</code><acronim><![CDATA[HiPerSemi]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>24097</team_members_id><team_members_names><![CDATA[ Doktorand: Željko Osrečki ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[semicoductors, microelectronics, bipolar transistors, photodetectors, photodiodes, CMOS, modeling, MOSFET, RF circuits]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The objective of this project is to provide notable scientific contributions by designing and utilizing the advanced semiconductor devices for the wireless communication circuits and solid-state optical detection applications. Research in this project will be grouped in three major activities, which are: (i) Horizontal Current Bipolar Transistor (HCBT) for RF Wireless Circuits, (ii) Characterization and applications of solid-state photodetectors, and (iii) Modelling of MOS, photodetector and other advanced electron devices. The novel wireless RF communication circuits such as mixer, frequency divider, voltage-controlled oscillator, RF switch and power amplifier will be designed and fabricated in HCBT technology as the first such circuits using the HCBT as an active component. The measurements of noise, reliability and on-wafer uniformity as well as linearity, gain and efficiency will be performed on transistors and circuits. The characterization of material properties of pure amorphous boron (PureB) layers will be made in order to determine the composition, electrical and optical properties of the layer and to develop the model of charge carrier transport through it. They will be correlated with electrical measurements to find out currently-unknown physical mechanisms responsible for the current reduction and for the record-high performance of photodides with PureB layers. The investigation of the novel materials such as Ge, SiGe and GaN for ultra-scaled advanced CMOS structures, i.e. FinFETs, will be performed by the development of novel models and simulation environment. The analog/RF parameters and characteristics will be extracted for FinFETs with different geometries and materials in order to determine the optimum structure for future RF systems.]]></summary_en></project><project>
<id>3903</id><title_hr><![CDATA[Napredna 3D percepcija za mobilne robotske manipulatore]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6310</user_id><user_firstLast_name>Robert Cupec</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-2657</code><acronim><![CDATA[ARP3D]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera Osijek, Fakultet elektrotehnike, računarstva i informacijskih tehnologija Osijek]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Electrical Engineering, Computer Science and Information Technology Osijek]]></institution_en><team_members_id>21326</team_members_id><team_members_names><![CDATA[ Doktorand: Petra Đurović ]]></team_members_names><keywords_hr><![CDATA[računalni vid, robotska manipulacija, prepoznavanje objekata, lokalizacija robota, segmentacija, 3D senzori]]></keywords_hr><keywords_en><![CDATA[computer vision, robot manipulation, object recognition, robot localization, segmentation, 3D sensors]]></keywords_en><summary_hr><![CDATA[Unatoč naglom napretku 3D računalnog vida, još uvijek postoji potreba za učinkovitijim, pouzdanijim i fleksibilnijim sustavima robotske percepcije. Osnovni cilj ovog projekta je razviti nove odnosno unaprijediti postojeće metode 3D robotskog vida za primjenu u zadacima robotske manipulacije. Predloženo istraživanje obuhvaća primjenu 3D senzora za izvođenje prototipnih zadataka koji uključuju manipulaciju objektima u kombinaciji sa samostalnim kretanjem u nestrukturiranoj okolini. Težište istraživanja je na robotskoj percepciji zasnovanoj na 3D oblacima točaka dobivenim 3D senzorima, dok su planiranje kretanja i hvatanja objekata uključeni samo radi evaluacije razvijenih rješenja s područja računalnog vida. Istraživanje će se provoditi u tri smjera: (i) segmentacija oblaka točaka i 3D modeliranje; (ii) prepoznavanje objekata; (iii) lokalizacija mobilnog robota. Radi olakšavanja komunikacije između čovjeka i robota, bit će razvijena metoda segmentacije oblaka točaka, koja će rezultirati modelom okoline u obliku zasebnih objekata relevantnih za mobilnu manipulaciju, što će omogućiti korisniku zadavanje zadataka robotu na jednostavan i intuitivan način. Razvijat će se više novih metoda s primjenom u okviru uobičajene strategije raspoznavanja objekata zasnovanog na značakama s ciljem povećanja računske učinkovitosti uz istovremeno postizanje visoke preciznosti i osjetljivosti (engl. precision and recall). Radit će se na osmišljavanju novih značajki za učinkovito generiranje hipoteza. Također će se razvijati nova metoda procjenjivanja vjerojatnosti generiranih hipoteza. Uz ovaj pristup, istraživat će se i primjena slučajnog evolucijskog algoritma pretraživanja te metode podudaranja grafova u prepoznavanju objekata. Razvijeni sustav prepoznavanja objekata bit će nadograđen i prilagođen za prepoznavanje mjesta u okviru sustava za lokalizaciju mobilnog robota. Sve metode razvijene u okviru projekta ispitat će se pokusima s mobilnim robotskim manipulatorom.]]></summary_hr><summary_en><![CDATA[Despite rapid advancement in 3D computer vision, there is still a need for more efficient, reliable and flexible robot perception systems. The main goal of this project is to develop new or improve existing 3D robot vision methods for application in mobile robot manipulation tasks. The proposed research considers application of 3D sensors in execution of prototypical tasks which include object manipulation combined with autonomous motion in an unstructured environment. The focus of the research is on robot perception based on 3D point clouds obtained by 3D sensors, while motion planning and grasping are involved only for the purpose of evaluation of the developed vision-based solutions. The research will be conducted in three directions: (i) point cloud segmentation and 3D modelling; (ii) object recognition; (iii) mobile robot localization. In order to facilitate human-robot communication, a point cloud segmentation method will be developed which will create environment models in the form of separate geometric objects relevant for mobile robot manipulation, providing a user with a simple and intuitive means of defining robot manipulation tasks. Several novel approaches within the framework of a common feature-based object recognition pipeline will be developed with the purpose of increasing the computational efficiency while achieving a high precision-recall characteristic. Novel features for efficient hypothesis generation will be designed. A novel hypothesis probability estimation approach will be developed. Furthermore, application of a random evolutionary search algorithm and graph matching in object recognition will be investigated. The developed object recognition system will be extended and adapted for place recognition within a mobile robot localization framework. All developed approaches will be evaluated by experiments with a mobile robot manipulation.]]></summary_en></project><project>
<id>3907</id><title_hr><![CDATA[Kooperativno upravljanje iskustvenom kvalitetom u pokretnim mrežama za interaktivne višemedijske aplikacije u računalom oblaku]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3964</user_id><user_firstLast_name>Lea Skorin-Kapov</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-6013</code><acronim><![CDATA[Q-MANIC]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>21062</team_members_id><team_members_names><![CDATA[ Doktorand: Irena Oršolić ]]></team_members_names><keywords_hr><![CDATA[Iskustvena kvaliteta, modeliranje iskustvene kvalitete, višemedijske aplikacije, računalni oblak, upravljanje iskustvenom kvalitetom]]></keywords_hr><keywords_en><![CDATA[Quality of Experience, QoE modelling, multimedia applications, cloud, QoE management]]></keywords_en><summary_hr><![CDATA[Zbog rasta broja novih pokretnih uređaja poput pametnih telefona i tableta, aplikacije i usluge namijenjene izvođenju na pokretnim uređajima su postale sastavni dio ljudske svakodnevice, sa značajnim utjecajem na ljudsku komunikaciju, učenje i zabavu. Potaknut zahtjevima poput skalabilnosti, fleksibilnosti i administracije, nastavio se trend migracije aplikacija u računalni oblak. Ono što i dalje ostaje ključni problem i razlikovno sredstvo između pružatelja usluga je ispunjavanje zahtjeva krajnjih korisnika s obzirom na očekivanu kvalitetu usluge, a što se naziva iskustvenom kvalitetom (QoE). Projekt Q-MANIC predložit će kooperativnu shemu za upravljanje iskustvenom kvalitetom, iskorištavajući nova znanja o iskustvenoj kvaliteti i poslovne modele usredotočene na kooperativne napore pružatelja usluga/usluga zasnovanih na računalnom oblaku i davatelja usluga u pokretnim mrežama kako bi se ostvarilo efikasnije upravljanje mrežnim resursima, a pritom i poboljšala iskustvena kvaliteta krajnjeg korisnika. Pored postojećih načina razmjene informacija u današnjim mrežama, bit će predloženi novi pristupi za koordinaciju i razmjenu informacija između aktora u postojećem vrijednosnom lancu pružatelja usluga. Bit će predloženi novi načini raspodjele resursa i novi algoritmi za prilagodbu usluge koji imaju u vidu različite strategije optimizacije. Kako bi pokazali korist i primjenjivost predloženog pristupa, prikazat ćemo dva slučaja uporabe koji predstavljaju primjer visoko interaktivnih i mrežno zahtjevnih višemedijskih aplikacija koje su dostavljaju putem pokretnih mreža (LTE/LTE-advanced/5G): usluga igranja u pokretu zasnovana na računalnom oblaku i usluga višekorisničkog video razgovora u pokretu. Oslonit ćemo se empirijski dobivene podatke kako bi specificirali modele iskustvene kvalitete i optimalne strategije za prilagodbu usluge. Shema za upravljanje iskustvenom kvalitetom koristit će mehanizme za upravljanje mrežom i strategije za prilagodbu aplikacije kako bi se poboljšala iskustvena kvaliteta i povećala efikasnost zauzeća resursa. Ključni doprinos bit će ugradnja kontekstualnih znanja i rezultata analize korisničkog ponašanja i interakcije u validirani model iskustvene kvalitete koji će biti korišten za efikasno upravljanje iskustvenom kvalitetom.]]></summary_hr><summary_en><![CDATA[With the proliferation of new mobile devices such as smartphones and tablets, mobile applications have become an integral part of our daily life activities, with a profound impact on the way people communicate, learn, or entertain. Driven by requirements such as scalability, flexibility, and administration, there is an increasing trend in migrating applications to the cloud. A key concern and differentiator between providers is meeting end users’ requirements in terms of service quality and expectations, referred to as Quality of Experience (QoE). The Q-MANIC project will propose a cooperative QoE management scheme exploiting new QoE knowledge and business models based on cooperative efforts between cloud/service providers and mobile network operators to achieve more efficient management of network/system resources, while enhancing end user QoE. Novel approaches for coordination and information exchange among actors involved in the service delivery chain will be proposed beyond those available in today&#39;s networks. Resource allocation and service adaptation algorithms will be proposed targeting different optimization strategies and taking into account multiple stakeholder perspectives. To demonstrate the benefits and applicability of the proposed approach, we address two use cases involving interactive, bandwidth intensive cloud-based applications delivered via mobile networks (LTE/LTE-advanced/5G): mobile cloud gaming and mobile multi-party video chat. We will rely on empirically obtained data to specify QoE models and optimal service adaptation strategies. The QoE management scheme will combine network management mechanisms and application adaptation strategies to bring improvements in QoE and efficiency of resource usage. A key contribution will be the incorporation of contextual knowledge and analysis of user behaviour and interactions into building validated QoE models that will be exploited in the context of QoE management.]]></summary_en></project><project>
<id>3909</id><title_hr><![CDATA[Non-Foster Source-load Networks and Metasurfaces (NOFSLO) ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>18913</user_id><user_firstLast_name>Silvio Hrabar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-3888</code><acronim><![CDATA[]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>24468</team_members_id><team_members_names><![CDATA[ Doktorand: Leo Vincelj ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>3910</id><title_hr><![CDATA[Arheologija jadranske brodogradnje i plovidbe]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5521</user_id><user_firstLast_name>Irena Radić Rossi</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-9657</code><acronim><![CDATA[AdriaS]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Arheologija, </scie_field_hr><scie_field_en>Archeology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zadru]]></institution_hr><institution_en><![CDATA[University of Zadar]]></institution_en><team_members_id>18977</team_members_id><team_members_names><![CDATA[ Doktorand: Katarina Batur ]]></team_members_names><keywords_hr><![CDATA[arheologija broda, brodogradnja, plovidba, Jadransko more, 3D modeliranje, podvodna robotika, povijest tehnologije]]></keywords_hr><keywords_en><![CDATA[nautical archaeology, shipbuilding, seafaring, Adriatic Sea, 3D modellin, underwater robotics, history of technology]]></keywords_en><summary_hr><![CDATA[Osnovni cilj projekta je potencirati sustavno interdisciplinarno proučavanje i interpretaciju arheoloških i povijesnih svjedočanstava o istočnojadranskoj brodogradnji i plovidbi. Bogata jadranska pomorska povijest, promatrana sa stanovišta tehnološkog razvoja drvene brodogradnje i plovidbe kroz vrijeme,  nije se donedavno sustavno proučavala zbog nedostatka odgovarajućih sredstava i solidne metodološke osnove. Projekt uzima u obzir kognitivne i praktične sljedove tehnološkog razvoja brodogradnje i plovidbe, proučavajući međusobne odnose tehnologije s jedne, te političkog, ekonomskog i kulturno-povijesnog konteksta s druge strane. Usredotočen je na problematiku iz svih vremenskih razdoblja ljudske prošlosti (prapovijest, antika, srednji vijek i rani novi vijek) putem aktivnog terenskog rada, arhivskog istraživanja i eksperimentiranja u području virtualne stvarnosti. Počevši od problematike ilirskih lemba i liburnskih liburna, do složene problematike velikih kasnorenesansnih trgovačkih brodova, on pruža sveobuhvatan pregled postignuća dosegnutih u prošlosti, te u hrvatsku znanost uvodi sustavan metodološki pristup proučavanju brodskih konstrukcija. Oslanjajući se na stanje istraživanja u području arheologije broda i pomorske povijesti na svjetskoj razini, projekt ima za cilj uvesti najsuvremenije metode proučavanja starih brodova, njihove opreme i tereta. On potiče inovativan interdisciplinarni pristup u procesu istraživanja, dokumentiranja i interpretacije najznačajnijih izravnih materjalnih svjedočanstava o istočnojadranskoj pomorskoj povijesti, promovirajući međunarodnu suradnju i umrežavanje među mladim znanstvenicima. Takav koncept stvorit će velik potencijal za čitavu zajednicu i potaknuti širi interes javnosti, naročito putem promidžbe projekta u javnim medijima i korištenja generiranog znanja u hrvatskoj turističkoj promociji. ]]></summary_hr><summary_en><![CDATA[The aim of the project is to enhance systematic interdisciplinary study and interpretation of the archaeological and historical record of shipbuilding and seafaring in the Eastern Adriatic. Its rich maritime history, seen through the technological development of wooden shipbuilding and seafaring and the dynamics that affected them over time, has not been systematically researched until recently, due to the lack of appropriate resources and the absence of a sound methodological basis. The project considers the cognitive and practical sequences of the technological development of shipbuilding and seafaring, studying the relationship between technology on one hand and the political, economic and cultural/historical context on the other. It focuses on issues from all periods of the human past (Prehistory, Classical Antiquity, Middle Ages and Early Modern period) through active fieldwork, archival research and virtual reality experimentation. From the problematic histories of the Illyrian lemboi and Liburnian liburnae, to the complex issues of the large late Renaissance merchantmen, it provides a comprehensive overview of the past achievements, and introduces into Croatian research the systematic methodological approach to the study of the ships’ hulls. Taking into consideration global state-of-the-art practices in the fields of nautical archaeology and maritime history, the project aims to introduce cutting edge methodologies of study of ancient ships, their equipment and cargoes. It will foster an innovative interdisciplinary approach in the process of research, recording and interpretation of the most significant direct material evidence of the Eastern Adriatic maritime past, while promoting international collaboration and networking among young researchers. Such concept will have great potential for community outreach and wider public interest, especially through promoting project in public media as well as using new knowledge in Croatian touristic promotion.]]></summary_en></project><project>
<id>3912</id><title_hr><![CDATA[Kristalno inženjerstvo višekomponentnih metaloorganskih materijala povezanih halogenskom vezom: ususret supramolekulskom ugađanju strukture i svojstava]]></title_hr><title_en><![CDATA[]]></title_en><user_id>356</user_id><user_firstLast_name>Dominik Cinčić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-4282</code><acronim><![CDATA[CrystEngMOM]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>21344</team_members_id><team_members_names><![CDATA[ Doktorand: Katarina Lisac ]]></team_members_names><keywords_hr><![CDATA[Halogenska veza, metaloorganski materijali, kokristali, supramolekulska kemija, mehanosinteza]]></keywords_hr><keywords_en><![CDATA[Halogen bond, metal-organic materials, cocrystals, supramolecular chemistry, mechanosynthesis]]></keywords_en><summary_hr><![CDATA[Glavni cilj predloženog istraživanja je razvijanje općeg principa priprave višekomponentnih kristalnih materijala (kokristala) ugodivih svojstava koji sadrže metaloorganske jedinice povezane halogenskim vezama. Ciljana sinteza kokristala metaloorganskih spojeva s donorima halogenske veze predstavljala bi značajan doprinos ne samo kristalnom inženjerstvu već i kemiji materijala te supramolekulskoj kemiji krutina. Predloženo istraživanje otvorit će put ka sintezi novih supramolekulskih krutina kontrolirane strukture i dimenzionalnosti sastavljenih od metaloorganskih jedinica. Takvi materijali mogu imati magnetska, optička i električna svojstva različita od svojstava organskih supramolekulskih materijala. Uz temeljne spoznaje o povezivanju metaloorganskih spojeva halogenskim vezama, proučit će se mogućnost primjene takovog povezivanja u ciljanoj sintezi fotoosjetljivih materijala, navlast kokristala sposobnih prevoditi svjetlostnu energiju u mehaničku. Drugi dio predloženog projekta bit će dizajn i sinteza organskih višekomponentnih materijala povezanih halogenskim vezama. Do sada je izučavanje halogenskih veza bilo osjetno ograničeno jednoličnošću dostupnih donora halogenske veze. Predložena istraživačka skupina spaja iskustva pojedinih suradnika u kovalentnoj sintezi, koordinacijskoj kemiji te kristalnim inženjerstvu, što će omogućiti sintezu kako novih donora halogenske veze, tako i metaloorganskih akceptora te supramolekulskih krutina. Ti će spojevi omogućiti temeljno istraživanje sintonâ halogenske veze, te izučavanje pouzdanih načina izrade proširenih metaloorganskih materijala povezanih halogenskim vezama i mogućnosti priprave izostrukturnih metaloorganskih kokristala radi ugađanja svojstava materijala unošenjem samo malih promjena u zadanu arhitekturu kokristala.]]></summary_hr><summary_en><![CDATA[The principal aim of the proposed research is to develop the first general designs for the assembly of functional multicomponent crystalline materials (cocrystals) involving metal-organic units organized by way of halogen-bonding interactions. The controlled and deliberate synthesis of halogen-bonded cocrystals involving metal-organic building blocks remains an outstanding challenge of crystal engineering, materials science and solid-state supramolecular chemistry. The proposed research will open a path to synthesize new molecular materials with controlled 1-, 2- or 3-D architectures, involving metal-organic building blocks which are expected to provide access to new magnetic, optical and electrical properties not usually available in carbon-based supramolecular networks. In particular, besides establishing the fundamental aspects of the design of halogen-bonded metal-organic materials, the proposed research will explore the application of these designs in the synthesis of photoresponsive switching materials, specifically of cocrystals capable of transforming light into mechanical motion. Another element of the proposed research project will be the design and synthesis of purely organic halogen-bonded multi-component materials. The field of halogen-bonded cocrystals has so far been heavily limited by the poor availability of diverse halogen bond donor building blocks. A particular strength of the assembled research team lies in the extensive experience in covalent synthesis, coordination chemistry and crystal engineering, enabling the synthesis of new halogen bond donors of different bonding strength and directionality, which will be employed for the fundamental studies of halogen bonding synthons, of reliable strategies for the construction of extended halogen bonded metal-organic materials, and of isostructural metal-organic cocrystals as a means to fine-tune the properties of solid materials by introducing minute differences into a given cocrystal architecture.]]></summary_en></project><project>
<id>3913</id><title_hr><![CDATA[Razvoj naprednih energetski učinkovitih struktura upravljanja generatorom sa stalnim magnetima bez mjernog člana ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5949</user_id><user_firstLast_name>Damir Sumina</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-4739</code><acronim><![CDATA[PMGEFC]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>22617</team_members_id><team_members_names><![CDATA[ Doktorand: Filip Jukić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[permanent magnet generator,  wind power generation, back-to-back converter, energy efficiency,  sensorless control,]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Renewable energy sources have been attracting great attention due to the cost increase, limited reserves and advanced environmental impact on fossil fuels. In the meantime, technology advancements, cost reduction and governmental incentives have made some renewable energy sources more competitive in the market. Among them, wind energy is the one of the fastest growing renewable energy sources. The conversion of the wind energy into electric energy is of a multidisciplinary nature, involving aerodynamics, mechanical systems, electric machines, power electronics, control theory, and power systems.The main goal of this project is to establish new research group which will improve the quality, performance and competitiveness of industrial sector in the field of wind power generation. The research group has already participated in the project for the development of advanced control structures for induction generator connected via back-to-back-converter to the grid in wind turbine application. As a step forward in innovation, research and development the research focus is set on permanent magnet synchronous generator (PMG) parameter identification, estimation of PMG rotor position using high frequency signal injection and speed estimation. Also, focus is on energy efficient based control method such as model predictive control of PMG. Advanced sensorless control algorithms for PMG will be developed and experimentally verified on the industrial laboratory model. Basic infrastructure for implementation and verification of developed algorithms exists in the Laboratory and for testing of advanced control structures on PMG laboratory model needs to be further upgraded. The final result will be the capability of research group for future cooperation with industrial partners for development of wind power generator systems and other generation systems.]]></summary_en></project><project>
<id>3914</id><title_hr><![CDATA[MAtematička analiza multifizikalnih problema koji uključuju tanke i kompozitne strukture i fluide]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6764</user_id><user_firstLast_name>Igor  Velčić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-6985</code><acronim><![CDATA[MAMPITCoStruFl]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>23191</team_members_id><team_members_names><![CDATA[ Doktorand: Josip Žubrinić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[thin structures, composite structures, dimensional reduction, homogenization, Gamma convergence, fluid-structure interaction, existence of solution ]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Composite materials are materials made from two or more constituent materials with different physical properties that, when combined, produce a material with characteristics different from those of its individual components. Thin and composite structures are of extreme importance for applications in engineering (e.g. building blocks, boats, ships, aircraft design) and biology (bones, biological tissues, blood vessels) where they are often subjected to fluid load. The analysis of these kind of complex multi-physics systems is very challenging from the mathematical point of view. Namely, the analysis of thin and composite structures and fluids includes the analysis of nonlinear partial differential equations (nonlinear PDEs), which leads to interesting mathematical questions (Gamma limits of a certain system of nonlinear equations with highly oscillating coefficients, existence for a certain system of nonlinear PDEs). This project plans the following: derivation of lower dimensional models in elasticity for highly oscillating materials, optimal design problems, derivation and analysis of fluid-structure interaction problems (derivation of coupling conditions, well-posedness and asymptotic stability analysis). We will use both Calculus of Variation and PDEs techniques to approach different topics, using the benefits from both. We strongly believe that this diversity will bring additional value to Croatian applied mathematics and will provide young people to develop and get acquainted with different approaches of the modern applied mathematics.]]></summary_en></project><project>
<id>3917</id><title_hr><![CDATA[Multidisciplinary Metrics for Soldier Resilience Prediction and Training]]></title_hr><title_en><![CDATA[]]></title_en><user_id>18918</user_id><user_firstLast_name>Krešimir Ćosić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-6899</code><acronim><![CDATA[]]></acronim><duration>19.10.2016 - 03.04.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>22772</team_members_id><team_members_names><![CDATA[ Doktorand: Ivan Kesedžić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>3921</id><title_hr><![CDATA[Energetski učinkovit asinkroni bežični prijenos]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6379</user_id><user_firstLast_name>Tomislav Matić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-4897</code><acronim><![CDATA[EEAWT]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera Osijek, Fakultet elektrotehnike, računarstva i informacijskih tehnologija Osijek]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Electrical Engineering, Computer Science and Information Technology Osijek]]></institution_en><team_members_id>13497</team_members_id><team_members_names><![CDATA[ Doktorand: Leon Šneler ]]></team_members_names><keywords_hr><![CDATA[bežični prijenos, asinkrona analogno-digitalna pretvorba, ultra-širokopojasni modulacijski postupci, bežične senzorske mreže, internet objekata]]></keywords_hr><keywords_en><![CDATA[wireless transmission, asynchronous analog-to-digital conversion, ultra-wideband modulation techniques, wireless sensor networks, internet of things]]></keywords_en><summary_hr><![CDATA[Kako bi se postigla energetska učinkovitost i smanjila površina integriranih sklopova za bežični prijenos, u posljednje se vrijeme primjenjuju asinkroni dizajn i širokopojasni modulacijski postupci. Veliki izazov pri projektiranju asinkronog bežičnog prijenosa je detekcija signala na strani prijemnika i uspostava više-korisničkog prijenosa. Prijedlog istraživačkih aktivnosti u sklopu ovog projekta je izrada energetski učinkovitih asinkronih integriranih sklopova za bežični prijenos analognog signala primjenjivih u senzorskim čvorovima bežičnih senzorskih mreža. Predloženi sustav se može podijeliti na dva podsustava, analogno-digitalni pretvornik i modulator za bežični prijenos. Na taj se način projektne aktivnosti mogu podijeliti u dvije faze. Prva faza uključuje izradu asinkronog analogno-digitalnog pretvornika, dok druga faza uključuje aktivnosti u izradi modulatora temeljenog na ultra-širokopojasnom (UWB) generatoru impulsa. Za izradu analogno-digitalnog pretvornika primjenjivat će se asinkroni sigma-delta modulator i različite tehnike temeljene na detekciji razine signala, dok će se za izradu UWB modulatora razmatrati modulacijske tehnike za digitalne ulazne signale. Zbog jako uskog impulsa i načina rada s iznimno niskim faktorom ispune, UWB modulacijski postupci su atraktivan izbor za energetski učinkovit bežični prijenos. Razvoj postojećih i izrada novih širokopojasnih modulacijskih postupaka u sklopu ovog projekta provodit će se s ciljem postizanja energetske učinkovitosti. Kako bi se zadovoljili osnovni ciljevi energetske i površinske učinkovitosti, prijenosni sustav će biti izrađen u CMOS procesu.]]></summary_hr><summary_en><![CDATA[To achieve high circuit power and size efficiency in wireless transmission circuits, recent contributions propose asynchronous design and spread spectrum communications. A great challenge in asynchronous wireless transmission is to accomplish signal detection at the receiver side and to establish multiuser transmission. The proposal of research activities in this project will be the design of low power asynchronous circuits for wireless transmission of analog input signals applicable as sensor nodes in short distance wireless sensor networks. The proposed system can be divided into two major subsystems consisting of the analog-to-digital (A/D) converter and the modulator for wireless transmission. Hence, the project activities can be divided into two major phases. The first phase will include asynchronous ADC design, where novel circuit architectures will be investigated, while the second phase will include activities on the modulator design incorporating ultra-wideband (UWB) pulse generators. The asynchronous sigma-delta modulator and various level crossing schemes will be investigated for A/D conversion, while UWB modulation techniques will be considered for the digitized signal modulation. Due to narrow pulse width and duty-cycled operation, UWB modulation techniques are a reasonable choice for the energy efficient wireless transmission. Evaluation of existing and development of new spread spectrum modulation techniques will be carried out to improve energy efficiency. To satisfy the major size and power consumption requirements, the transmission circuitry will be designed in CMOS process.]]></summary_en></project><project>
<id>3922</id><title_hr><![CDATA[Pametna okruženja za poboljšanje kvalitete života]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3685</user_id><user_firstLast_name>Mladen Russo</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-1241</code><acronim><![CDATA[ELISE]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Fakultet elektrotehnike, strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Electrical Engineering, Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>21298</team_members_id><team_members_names><![CDATA[ Doktorand: Luka Kraljević ]]></team_members_names><keywords_hr><![CDATA[pametne okoline, nosiva sučeljam računalni vid, proširena stvarnost, prepoznavanje govora, prikupljanje energije iz okoline, lokalizacija, zv. kulise]]></keywords_hr><keywords_en><![CDATA[smart environments, wearable interfaces, computer vision, augmented reality, speech recognition, ambient energy harvesting, localization, soundscaping]]></keywords_en><summary_hr><![CDATA[Pametna okolina predstavlja svijet pun različitih senzora i pametnih uređaja koji neprimjetno rade skupa, čineći svakodnevni život lakšim i udobnijim. Projekt ELISE je zamišljen kao interdisciplinarni istraživački pristup usmjeren ka poboljšanju tehnologija na kojima se temelje pametne okoline, s ciljem uspostavljanja okvira za razvoj raznih real-life usluga i aplikacija u pametnim okolinama. Glavna područja istraživanja će uključivati senzore niske potrošnje i prikupljanje energije iz okoline, nosiva sučelja, prepoznavanje govora, računalni vid, prepoznavanje objekata i teksta, proširenu stvarnost, lokalizacijske tehnologije, zvučne kulise i auralizaciju. Svi članovi našeg interdisciplinarnog tima su visoko kvalificirani stručnjaci u tim područjima, budući da su već objavili doktorske disertacije i visoko kvalitetne radove u predloženim područjima istraživanja. Projekt će također doprinijeti obuci dva nova doktoranda omogućujući im odlične uvjete za njihova istraživanja. Istraživanja u svim područjima će se temeljiti na integriranom pristupu s vizijom razvoja real-life aplikacija u pametnoj okolini. Osobito dvije aplikacije će usmjeravati naš rad, te su planirane za izradu prototipa i demonstraciju u posljednjim fazama projekta: Smart sightseeing (Pametno razgledavanje) i Smart museum tour (Pametna tura muzejom). Temeljit će se na sučelju proširene stvarnosti (Augmented Reality – AR) na način da će se objekti od interesa automatski prepoznavati te omogućiti predstavljanje dodatnih sadržaju korisniku, također će biti opremljeni modulom za lokalizaciju, imati mogućnost poboljšanja AR pomoću zvučnih kulisa, biti upravljani pomoću govora i pametnih nosivih sučelja, npr. sučelje za prepoznavanje pokreta ruku, uz sposobnost detektiranja korisnikovih emocionalnih stanja i prilagođavanja sadržaja sukladno tome. Razvijeni moduli također će tvoriti osnovu za razvoj drugih aplikacija za lakši život u pametnim okolinama, uključujući domove, bolnice, ustanove za brigu o starijima i nemoćnima, uredima, gradovima...]]></summary_hr><summary_en><![CDATA[Smart environment represents a world full of different sensors and smart devices seamlessly working together, making everyday living easier and more comfortable. ELISE is envisioned as an interdisciplinary research approach aimed for improving the technologies on which smart environments are based, with the goal of establishing a framework for developing various real-life services and applications in smart environments. Primary areas of research will include low power sensing and ambient energy harvesting, wearable interfaces, speech recognition, computer vision, object and text recognition, augmented reality, localization technologies, soundscaping and auralization. All members of our interdisciplinary team have skills and experience in these areas since their PhD theses and published papers are directly related to the proposed research. ELISE will also contribute to the training of two new PhD students providing excellent conditions for their research. Research in all areas will be based on integrated approach with a vision of developing real-life smart environment applications. Particularly two applications will drive our work and are planned for prototyping and demonstration in the last stages of the project: smart sightseeing and smart museum tour. They will be based on augmented reality interface in a way that objects of interest are recognized in the scenes enabling presentation of additional content to the user, they will be equipped will localization module, have the ability of soundscape to enhance AR, be controlled via speech and wearable smart interfaces, e.g. hand gesture recognition interface, with the ability of detecting user&#39;s emotional states and adapting the content accordingly. Developed modules will also form the basis for developing other applications for easier living in smart environments, including homes, hospitals, care facilities, offices, cities...]]></summary_en></project><project>
<id>3925</id><title_hr><![CDATA[Mjerenje svojstava Higgsovog bozona i potraga za novom fizikom detektorom CMS]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6738</user_id><user_firstLast_name>Ilja Doršner</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-6865</code><acronim><![CDATA[HIGGSPRO]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Fakultet elektrotehnike, strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Electrical Engineering, Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>22637</team_members_id><team_members_names><![CDATA[ Doktorand: Toni Vrdoljak ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[CMS detector, LHC, Higgs boson, leptoquarks, electron reconstruction]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The discovery of a Higgs boson by the ATLAS and CMS experiments at the LHC has opened a new era for particle physics, namely precision consistency tests of the SM Higgs boson. The proposed project has two main goals: measurement of the SM Higgs boson properties, as the window for the search for new physics beyond the Standard model, and a direct search for new physical phenomena looking for hypothetical particles called leptoquarks. In the first year of project we will explore the data collected by the CMS experiment during 2011 and 2012, while preparing for the LHC Run II, which is expected to start in 2015. Preparation consists of developing and implementing new electron reconstruction, identification and isolation algorithms, which will be used by the whole collaboration when the new data taking starts.  During the second year of the project we will commission and maintain electron reconstruction algorithms, start collecting the data and make first analysis at new energy. During third and fourth year we will explore the data and concentrate to the two main goals of the project: SM Higgs boson properties measurements and search for new physics. ]]></summary_en></project><project>
<id>3929</id><title_hr><![CDATA[Jako korelirani elektroni u slojnim organskim materijalima i manganitima: niskofrekventna pobuđenja i nelinearna dinamika]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3184</user_id><user_firstLast_name>Tomislav Ivek</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-1547</code><acronim><![CDATA[SCEinLOM]]></acronim><duration>16.10.2017 - 16.02.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut za fiziku]]></institution_hr><institution_en><![CDATA[Institute of Physics in Zagreb]]></institution_en><team_members_id>23242</team_members_id><team_members_names><![CDATA[ Doktorand: Željko Rapljenović ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[correlated electrons, unconventional superconductivity, colossal magnetoresistance, charge and spin orderings, quantum spin liquids, nonlinear effects]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Strongly correlated electrons in solids generate broken symmetry phases and collective excitations that are fundamental to our understanding of the most intriguing properties of quantum matter. Phase diagrams of layered cuprate, organic superconductors and manganites, as well as some other transition-metal systems, famous for the phenomena of unconventional superconductivity (SC) and colossal magnetoresistance (CMR), respectively feature an extraordinary complexity of electronic phases, which can be tuned by chemical composition, magnetic field and pressure. A prominent place among these phases is held by stripes, patterns of charge order (CO), which are thought to be linked to SC and CMR, as well as by CO phases with ferroelectric signatures due to a rich variety of nonlinear properties and complex dynamics. Despite intense research efforts, these basic issues in condensed matter physics bear many open questions. We propose to investigate the nature of charge/spin-ordered phases and their motion developed in series of organic and transition metal solids applying modern experimental tools available at the Institute of Physics, Zagreb and at the Department of Physics, Faculty of Science, University of Zagreb (dielectric spectroscopy, pulsed nonlinear conductivity, ac/dc resistance, magnetoresistance and Hall effect).  Our overall contributions to the field and our expertise in condensed matter physics have been internationally recognized. Together with the available experimental means, this positions us as researchers fully suitable and competent for the proposed task. Our international partners will give an added value with samples, experiments and expertise in the terahertz and infrared spectroscopy. Integrated students and postdocs are going to acquire advanced skills in the materials science and learn to solve complex problems in a collaborative environment. Results will be published in international scientific journals and presented at international conferences.]]></summary_en></project><project>
<id>4025</id><title_hr><![CDATA[Imunosni mehanizmi u razvoju upale i metaboličkog sindroma u debljini]]></title_hr><title_en><![CDATA[Immune mechanisms in development of inflammation and metabolic syndrome in obesity]]></title_en><user_id>7082</user_id><user_firstLast_name>Bojan Polić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-9306</code><acronim><![CDATA[INFLAMETAB]]></acronim><duration>01.06.2017 - 31.10.2021</duration><status>Završio</status><financ_value>132.532,75 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, Clinical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Medicine]]></institution_en><team_members_id>19737, 19670, 19638, 19824, 4999, 25199, 25607, 856077, </team_members_id><team_members_names><![CDATA[Marko Šestan, Sonja Valentić, Tamara Turk Wensveen, Marko Zelic, ĐURĐICA CEKINOVIĆ, Ante Benić, Valentina Obadić, Sanja Mikašinović, ]]></team_members_names><keywords_hr><![CDATA[Upala, Debljina, Rezistencija na inzulin, metabolički sindrom, diabetes, NASH,  stanice NK, urođeni limfociti, gamma delta limfociti T, citokini]]></keywords_hr><keywords_en><![CDATA[Inflammation, Obesity, Insuline resistance, Metabolic Syndrome, diabetes, NASH, NK cells, ILCs, gamma delta T cells, macrophages, cytokines]]></keywords_en><summary_hr><![CDATA[Pretilost je jedan od najznačajnijih i rastućih medicinskih zdravstvenih problema današnjice. Procjenjuje se da trenutno na svijetu živi više od pola milijarde debelih ljudi i  preko milijarde onih s prekomjernom težinom. Značajan broj njih oboljeva od šećerne bolesti tipa 2 (DM2) i nealkoholne bolesti masne jetre (NAFLD), koje često koegzistirjau i dijele patogene abnormalnosti debljine kao što su rezistencija na inzulin (IR), dislipidemija i hipertenzija, što su karakteristike metaboličkog sindroma. Debljina je povezana sa kroničnom sistemskom upalom niskog intenziteta za koju se smatra da je važan pozadinski uzrok IR, koja dovodi do DM2 i NAFLD. Ciljanje mehanizama upale u obje bolesti je stoga obećavajuće za buduće pristupe u terapiji. No, stvarni mehanizmi koji induciraju ili pogoršavaju upalu u debljini i uzrokuju prijelaz iz stadija pre-dijabetesa u DM2 ili iz stadija jetrene steatoze u nealkoholni steatohepatitis (NASH) su još uvjek uglavnom nejasni. Stoga je bolje poznavanje imunosnih uzroka DM2-a i NASH-a neophodno potrebno. U ovom projektu namjeravamo istražiti imunosne mehanizme koji su važni za indukciju upalnih procesa u visceralnom masnom tkivu (VAT) i jetri, te su odgovorni za razvoj DM2 i NASH. Dodatno, naš cilj je istražiti virusne faktore koji pogoršavaju IR i imaju učinak na tranziciju iz pre-dijabetesa u DM2. U ovoj studiji koristi ćemo dobro pozate mišje modele dijetom inducirane debljine (DIO), te odgovarajuće mišje mutante i druga oruđa kako bismo odgovorili na postaljena pitanja. Isto tako, usporediti ćemo eksperimentalne podatke sa podacima analize uzoraka sakupljenih od pretilih bolesnika što je također planirano projektom. Ovaj projekt povezuje imunologiju, virologiju i endokrinologiju. Istraživački tim ima dovoljno iskustva i znanja za uspješno provođenje predloženog istraživanja, te će bti sposoban stvoriti nova vrijedna i korisna saznanja o razvoju DM2-a i NASH-a. ]]></summary_hr><summary_en><![CDATA[Obesity is one of the most prominent and growing health problem of our time. It is estimated that more than a half billion of obese and another billion of overweight people live currently in the world. A significant number of them develop Diabetes Mellitus type 2 (DM2) and Non-alcoholic Fatty Liver Disease (NAFLD), which often coexist and share pathogenic abnormalities of obesity like insulin resistance (IR), dyslipidaemia and hypertension, which are features of the metabolic syndrome. Obesity is associated with a chronic systemic low-grade inflammation which is thought to be an important underlying cause of IR that leads to DM2 and NAFLD. Targeting of the underlying mechanisms of inflammation in both diseases therefore holds much promise for future therapies. However, the exact mechanisms that induce or aggravate inflammation and trigger transition from pre-diabetes to DM2 or from hepatic steatosis to non-alcoholic steatohepatitis (NASH) in obesity are still largely unclear. A better understanding of immunological causes of DM2 and NASH is therefore required.In this project we aim to investigate immune mechanisms that are important for induction of inflammatory processes in visceral adipose tissue (VAT) and liver, which are responsible for development of DM2 and NASH. In addition, our goal is to investigate viral factors that aggravate IR such as impact progression from pre-diabetes to DM2. In our study we will use well established mouse models of diet induced obesity (DIO) and appropriate mouse mutants and tools to address raised questions. We will compare experimental data with the analysis of samples collected from obese human subjects also planned in the project. Our project bridges immunology, virology and endocrinology. Our team has enough experience and expertise to drive successfully proposed research and will be able to provide valuable new insights in the development of DM2 and NASH. ]]></summary_en></project><project>
<id>4026</id><title_hr><![CDATA[Genetsko poboljšanje i optimizacija potencijala rodnosti pšenice]]></title_hr><title_en><![CDATA[Genetic improvement and optimization of wheat yield potential]]></title_en><user_id>7647</user_id><user_firstLast_name>Dario Novoselović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-2178</code><acronim><![CDATA[GI OPTI WHEAT]]></acronim><duration>01.03.2017 - 30.06.2021</duration><status>Završio</status><financ_value>125.024,89 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Poljoprivredni institut Osijek]]></institution_hr><institution_en><![CDATA[Agricultural Institute Osijek]]></institution_en><team_members_id>19238, 19287, 19286, 19239, 1248, 19311, 19397, 825, 1259, 7754, 19290, 19509, 19688, 5095, 20111, 7747, 20271, 20332, 23241, 25033, 25332, </team_members_id><team_members_names><![CDATA[Sonja Grljušić, Georg Drezner, Krešimir Dvojković, Brigita  Popović, Jasenka Ćosić, Marko Maričević, Meri Engler, Daniela Horvat, Karolina Vrandečić, Hrvoje Šarčević, Ana Lovrić, Nikolina Šimić, Zoran Užila, Gordana Šimić, Ivica Ikić, Zdenko Lončarić, Alison Bentley, Ian Mackay, Marko Ivić, Ivana Plavšin, Magdalena Matić, ]]></team_members_names><keywords_hr><![CDATA[pšenica, urod, kvaliteta, zrno, dušik, Fusarium,  ]]></keywords_hr><keywords_en><![CDATA[wheat, yield, quality, grain, nitrogen, Fusarium, ]]></keywords_en><summary_hr><![CDATA[Današnji i budući zahtjevi za pšenicom u svijetu zahtijevaju korištenje niza novih pristupa u povećanju prinosa pšenice kako u svijetu tako i u regiji. Najizravnije i najočitije rješenje za ove izazove je kroz povećanje produktivnosti usvajanjem germplazme pšenice povećanog genetskog potencijala rodnosti i adaptabilnosti u različitim proizvodnim uvjetima. Prema tome, glavni ciljevi ovog projektnog prijedloga su: 1. fenotipizacija i karakterizacija elitne germplazme pšenice iz regije za najvažnija agronomska svojstva i svojstva kvalitete, svojstva vezanih uz NUE (nitrogen use efficiency), te tolerantnosti na najvažnije biotske stresove kao što je fuzarijska palež klasa u različitim proizvodnim uvjetima i režimu dušične gnojidbe, 2. genotipizirati odabranu germplazmu pšenice na poznate funkcionalne markere, 3. ponuditi ideotip pšenice kako bi pomogli oplemenjivačima pšenice da odaberu roditelje i optimiziraju svojstva pšenice kroz selekcijski proces ciljajući područje jugoistočne Europe, 4. razviti strategiju prema modelu temeljenom na analizi interakciji genotip*okolina (GEI) koja će povećati učinkovitost programa oplemenjivanja pšenice, i 5. identificirati superiorne genotipove pšenice koji će se koristiti u razvoju mapirajućih  i oplemenjivačkih populacija za buduća istraživanja i oplemenjivački  rad kako bi se osigurala buduća dobit od oplemenjivanja i gospodarska korist za proizvođače pšenice u Hrvatskoj. Nadamo se da će ovaj inovativni i integracijski pristup u istraživanju pšenici rezultirati objavom radova visoke kvalitete, novom nacionalnom istraživačkom platformom za pšenicu i da će povećati konkurentnost i sudjelovanje u od EU financiranim istraživačkim projektima.]]></summary_hr><summary_en><![CDATA[Current and future demands for world wheat production and security require the  exploitation of a suite of novel  approaches to increase both regional and worldwide wheat yields. The most direct and obvious solution to these challenges will be to increase productivity through the adoption of wheat germplasm with improved genetic potential and adaptability to diverse growing conditions. Thus the main objectives of this project proposal include: 1. phenotyping and characterizing elite wheat germplasm from the region for the most important agronomic and quality traits, nitrogen use efficiency (NUE) related traits, and tolerance to main biotic stresses such as Fusarium head blight under different growing conditions and regimes of nitrogen, 2. genotyping selected wheat germplasm using functional markers, 3. identification of wheat ideotypes to help breeders to select parents and optimize wheat traits through selection process targeting South-Eastern European region, 4. development of a modeling strategy for GEI analysis that will help to increase the efficiency of a plant breeding program and 5.  Identification of superior wheat genotypes that will be used to develop mapping and breeding populations for future research and breeding purposes in order to ensure future genetic gains in wheat improvement and economic benefits to farmers community in Croatia.This innovative and integrative approach to wheat research will result in high-quality research papers, a newl national wheat research platform and increased  competitiveness and participation in EU funded research projects.]]></summary_en></project><project>
<id>4027</id><title_hr><![CDATA[Istraživanje granice između neurodegeneracije i neuroregeneracije: identifikacija ključnih molekula pomoću proteomike i funkcionalnih testova na leđnoj moždini sisavaca]]></title_hr><title_en><![CDATA[Exploring the borderland between neurodegeneration and neuroregeneration: identification of key molecules with proteomics and functional assays in the mammalian spinal cord]]></title_en><user_id>5326</user_id><user_firstLast_name>Miranda Mladinić Pejatović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-7060</code><acronim><![CDATA[DefineREgenAgeMode]]></acronim><duration>01.06.2017 - 31.10.2021</duration><status>Završio</status><financ_value>125.821,22 eur</financ_value><scie_area_hr>Prirodne znanosti, Biotehničke znanosti, </scie_area_hr><scie_area_en>Natural sciences, Biotechnical sciences, </scie_area_en><scie_field_hr>Biologija, Biotehnologija, </scie_field_hr><scie_field_en>Biology, Biotechnology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Fakultet biotehnologije i razvoja lijekova]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Biotechnology and Drug Development]]></institution_en><team_members_id>12833, 19202, 19201, 19076, 19202, 25289, </team_members_id><team_members_names><![CDATA[Andrea Nistri, Ivana Tomljanović, Antonela Petrović, Jelena Ban, Ivana Tomljanović, Zrinko Baričević, ]]></team_members_names><keywords_hr><![CDATA[regeneracija sisavaca, Monodelphis domestica, oposum, embrionalni razvoj, središnji živčani sustav, leđna moždina, rast aksona, proteomika]]></keywords_hr><keywords_en><![CDATA[mammalian regeneration, Monodelphis domestica, opossum, embryonal development, central nervous system, spinal cord, axonal growth, proteomics]]></keywords_en><summary_hr><![CDATA[Jedan od glavnih izazova suvremene biologije je nemogućnost odraslog središnjeg živčanog sustava (SŽS) sisavaca da se regenerira i oporavi nakon ozljede. Za razliku od odraslih sisavaca, niži kralježnjaci, kao što su ribe i vodozemci, te viši kralježnjaci tijekom embrionalnog razvoja mogu obnoviti znatan dio svog SŽS. Vrlo je nejasno kako se i zašto regenerativni potencijal gubi tijekom evolucije i razvoja i zašto je vrlo ograničen u odraslih sisavaca. Povoljan model za istraživanje i otkrivanje osnove ovog gubitka je mladi oposum (Monodelphis domestica). Oposumi su tobolčari koji se rađaju vrlo nezreli i imaju jedinstvenu mogućnost uspješne regeneracije leđne moždine nakon ozljede u prva dva tjedna svog života, te stoga pružaju izuzetnu priliku za istraživanje neuronalne regeneracije. U svojim sam prethodnim istraživanima identificirala gene čiji se izražaj razlikuje u tkivu leđne moždine oposuma koji imaju ili nemaju sposobnost regeneracije. U ovom istraživanju želimo nadograditi prijašnji pristup analizom proteoma tkiva leđne moždine oposuma različite dobi, kako bi se otkrile molekule povezane s regenerativnim rastom aksona i proliferacijom matičnih stanica. Inhibicijom aktivnosti odabranih molekula ispitat će se njihova funkcionalna uloga u regeneraciji živčanog tkiva, koristeći in vitro preparate intaktne leđne moždine i napredno mikroskopiranje. Paralelno, pripremiti ćemo i analizirati primarne stanične kulture iz tkiva leđne moždine oposuma različite dobi, kako bi testirali odabrane molekule, s težištem na onima koje kontroliraju aktivnost matičnih stanica vezanu za regeneraciju. Ovo originalno interdisciplinarno temeljno istraživanje koristi jedinstveni životinjski model i ujedinjuje napredne tehnike biotehnologije te molekularne i stanične neurobiologije. Rezultati ovog projekta mogli bi dati značajan doprinos razumijevanju regeneracije živčanog tkiva sisavaca, ali i pružiti osnovu za buduće nove terapijske postupke vezane za neurodegenerativne poremećaje.]]></summary_hr><summary_en><![CDATA[One of the major challenges of modern biology concerns the inability of the adult mammalian central nervous system (CNS) to regenerate and repair itself after injury. Unlike the situation in adult mammals, lower vertebrates, such as fish and amphibians, and embryonal higher vertebrates can regenerate significant portions of their CNS. It is poorly understood why this potential is lost with evolution and development, and becomes very limited in adult mammals. An advantageous model to understand the basis of this loss is the neonatal opossum (Monodelphis domestica). Opossums are marsupials born immature, with the unique ability to successfully regenerate spinal cord after injury postnatally: this property, therefore, offers an exceptional tool to study neuro-regeneration. In my previous studies I have identified the genes differentially expressed in the regenerating and non-regenerating opossum spinal tissue. In the present application we wish to upgrade approach and to analyze the proteoms of the spinal tissue of the opossums at different ages, looking for molecules associated with regenerative axon growth and stem cell proliferation. The activity of candidate molecules will be inhibited to investigate their functional role in neuronal regeneration using the in vitro intact spinal cord preparation and advanced imaging. In parallel, we will prepare and analyze opossum primary spinal cell cultures made from the animals of different age, to test candidate proteins, with focus on those involved in stem/progenitor cell activity related to regeneration. This original interdisciplinary basic research project, unique in the choice of the animal model to be used, combines advanced techniques of biotechnology and molecular and cellular neurobiology. The results of the project would make substantial contribution to our understanding of neuronal regeneration in mammals, and also provide candidate targets for future novel therapeutic interventions for neurodegenerative disorders.]]></summary_en></project><project>
<id>4032</id><title_hr><![CDATA[Tranzicija hrvatskih elita iz Habsburške Monarhije u jugoslavensku državu]]></title_hr><title_en><![CDATA[The Transition of Croatian Elites from the Habsburg Monarchy to the Yugoslav State]]></title_en><user_id>4459</user_id><user_firstLast_name>Iskra Iveljić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-5974</code><acronim><![CDATA[Croelite]]></acronim><duration>01.03.2017 - 30.12.2020</duration><status>Završio</status><financ_value>50.273,94 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Povijest, </scie_field_hr><scie_field_en>History, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>19116, 19067, 19089, 19087, 19326, 19275, 19356, 19406, </team_members_id><team_members_names><![CDATA[Ida Ograjšek Gorenjak, Željko Dugac, Božena Vranješ-Šoljan, Branimir Janković, Miha Preinfalk, Žarko Lazarević, Nikola Tomašegović, Mark Cornwall, ]]></team_members_names><keywords_hr><![CDATA[Croatia, Elites, Transition, Habsburg Monarchy, Yugoslavia]]></keywords_hr><keywords_en><![CDATA[Hrvatska, elite, tranzicija, Habsburška Monarhija, Jugoslavija]]></keywords_en><summary_hr><![CDATA[Cilj projekta je analizirati različite segmente hrvatskih elita tijekom posljednje faze postojanja Habsburške Monarhije te prikazati njihovu tranziciju u jugoslavensku državu, obuhvaćajući period od kasnog 19. stoljeća do 1930-ih. Taj je proces  bio za mnoge pripadnike hrvatskih elita težak jer su njime uvedene velike promjene u političkom, nacionalnom, društvenom, gospodarskom, kulturnom, obrazovnom i vojnom aspektu, da se spomenu samo najvažniji. Opći kontekst tranzicije bio je vrlo složen i zahtjevan, te se odvijao na nekoliko razina – nacionalnoj, jugoslavenskoj i međunarodnoj. Njena posljedica bio je i pomak vanjskopolitičke orijentacije države sa središnje na jugoistočnu Europu, iako su srednjoeuropski utjecaji još uvijek bili prisutni na mnogim poljima. Projektni će tim istraživati plemstvo, privrednu i intelektualnu elitu (sveučilišne profesore, političare, liječnike, odvjetnike), administrativnu elitu i poznate žene obuhvaćajući  njihov javni i profesionalni ali i svakodnevni život, povlačeći usporedbe s drugim elitama, ponajprije onima iz Slovenije.Projekt će komparirati mehanizme regrutacije elite u posljednjoj fazi Habsburške Monarhije i prvoj fazi jugoslavenske države, pokazujući (in)kongruencije između naslijeđenih struktura, utjecaja i načina života s novim političkim realnostima.]]></summary_hr><summary_en><![CDATA[The aim of the project is to analyse various segments of Croatian elites during the last phase of the Habsburg Monarchy and to show their transition into the new Yugoslav state, covering thus the period from the late 19th century until the 1930s. This process was strenuous for many members of Croatian elites, since it brought about major changes in political, national, social, economic, cultural, educational and military aspect, to mention just the most important ones. The general context of the transition was very complex and demanding, and it took place on several levels, the national, the Yugoslav and the international. It also implied a shift from Central European to Southeastern European orientation, yet in many fields Central European influences were still present. The project team will research the nobility, the businessmen, intellectual elite  (university professors, politicians, doctors of medicine, lawyers) administrative elite and renown women, encompassing their public and professional as well as everyday life. Comparisons will be drawn with other elites, especially with the Slovenian elites. The project  should compare the mechanisms of regrutation of elites in the last phase of the Habsburg state and the first phase of the Yugoslav one, showing (in)congruencies between inherited structures, influences and a way of life with new political realities.   ]]></summary_en></project><project>
<id>4038</id><title_hr><![CDATA[Koartikulacija u hrvatskom govoru: instrumentalno istraživanje]]></title_hr><title_en><![CDATA[Coarticulation in Croatian speech: instrumental investigation]]></title_en><user_id>19048</user_id><user_firstLast_name>Marko Liker</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-5367</code><acronim><![CDATA[KROKO / CROCO]]></acronim><duration>02.03.2017 - 01.07.2021</duration><status>Završio</status><financ_value>47.090,05 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filologija, </scie_field_hr><scie_field_en>Philology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>574, 19504, 2844, 19391, 28775, </team_members_id><team_members_names><![CDATA[Vesna Mildner, Arnalda Dobrić, Ines Carović, Ana Vidović Zorić, Karla Zvonar, ]]></team_members_names><keywords_hr><![CDATA[govor, koartikulacija, instrumentalno istraživanje, elektropalatografija (EPG), ultrazvuk (UTI), tipični govor, atipični govor, hrvatski]]></keywords_hr><keywords_en><![CDATA[speech, coarticulation, instrumental investigation, electropalatography (EPG), ultrasound (UTI), typical speech, atypical speech, Croatian]]></keywords_en><summary_hr><![CDATA[Tijekom govora govorni je trakt pod stalnim utjecajem izgovornih zahtjeva više glasova, zbog čega se pokreti izgovornih organa ponekad preklapaju u vremenu i utječu jedan na drugi. Taj se fenomen naziva koartikulacijom i jedan je od središnjih istraživačkih problema u fonetskim i govornim znanostima. Ovaj je istraživački projekt motiviran upravo relevantnošću problema koartikulacije u aktualnom istraživačkom prostoru te nedostatkom instrumentalnih podataka o koartikulacijskim procesima u hrvatskom govoru.Opći je cilj projekta istražiti koartikulacijske procese u tipičnom (urednom) i atipičnom (oštećenom) govoru hrvatskih ispitanika. Istraživanje tipičnoga govora dat će uvid u koartikulacijski potencijal (odnos koartikulacijskog pritiska i otpora) hrvatskih glasova, a istraživanje atipičnog govora pridonijet će boljem razumijevanju senzomotorike govora i njezinog odnosa s koartikulacijom. U cjelini, rezultati će pridonijeti objašnjenju jezično-specifičnih i jezično-univerzalnih aspekata koartikulacije te razlikovanju njezinih tipičnih od atipičnih karakteristika.Ovaj projekt inovativan je u sljedećem: 1. vrsti govornog materijala (smanjenje utjecaja neprirodnih komunikacijskih uvjeta u dosadašnjem laboratorijskom snimanju govora te približavanje spontanom govoru, što će omogućiti relevantnije rezultate), 2. istraživačkim metodama (primijenit će se više instrumentalnih fizioloških i akustičkih tehnika za snimanje govora) te 3. vrsti ispitanika (prvi puta u Hrvatskoj koartikulacija će se istraživati u tipičnom i atipičnom govoru).Krajnji korisnici rezultata ovih istraživanja su u području govornih tehnologija i sinteze govora (stvaranje umjetnog govora te komunikacija čovjek-stroj), klinički fonetičari i logopedi (uspješno odvajanje tipičnih i atipičnih karakteristika govora te kvantitativan instrumentalni pristup dijagnozi i terapiji govornih poteškoća) te lingvisti i fonetičari (bolje razumijevanje složenog govornog funkcioniranja čovjeka).]]></summary_hr><summary_en><![CDATA[During speech vocal tract is under constant influence of more than one speech segment, which causes speech movements to overlap in time and speech segments to influence one another. This phenomenon is called coarticulation and is one of the central research problems in phonetic and speech sciences. This research project is motivated by the relevance of the problem of coarticulation in the research area and by the relative lack of instrumental data on coarticulation in Croatian.The general aim of the project is to investigate coarticulation in typical and atypical (impaired) Croatian speech. The investigation of typical speech will offer the opportunity to develop coarticulatory potential for Croatian speech sounds (the relation between coarticulatory pressure and resistance), while the investigation of atypical speech will contribute to the understanding of speech  sensomotorics and its relation to coarticulation. Main contributions of the research project are: the understanding of language-specific and language-universal aspects of coarticulation as well as more successful differentiation between coarticulation in typical and atypical speech.This project is innovative for three main reasons: 1. type of speech material (the development of communicative situations for the elicitation of quasi-natural speech in the laboratory, which will contribute to more reliable results), 2. research techniques (several instrumental techniques will be used) and 3. types of speakers (coarticulation in Croatian speech will be investigated in typical and atypical speech for the first time).The end users are expected in the following fields: speech technology and synthesis (the development of artificial speech and human-machine communication), clinical phonetics and speech therapy (successful differentiation between typical and atypical speech as well as quantitative approach to diagnosis and therapy) and linguistics and phonetics (better understanding of human speech).]]></summary_en></project><project>
<id>4041</id><title_hr><![CDATA[Razvoj kapilarne mikroprobe za MeV SIMS s primjenom na analizu bioloških materijala]]></title_hr><title_en><![CDATA[Development of the capillary microprobe for MeV SIMS with application on analysis of biological samples ]]></title_en><user_id>2755</user_id><user_firstLast_name>Ivančica Bogdanović Radović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-1698</code><acronim><![CDATA[BioCapSIMS]]></acronim><duration>15.05.2017 - 14.08.2020</duration><status>Završio</status><financ_value>99.117,39 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, Kemija, Biologija, </scie_field_hr><scie_field_en>Physics, Chemistry, Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>4670, 4629, 24346, 25285, </team_members_id><team_members_names><![CDATA[Zdravko Siketić, Milko Jakšić, Marko Barac, Marko Brajković, ]]></team_members_names><keywords_hr><![CDATA[teški ioni, kapilarna mikroproba, MeV SIMS, biološki uzorci, ispodmikronska rezolucija]]></keywords_hr><keywords_en><![CDATA[heavy ions, capillary microbeam, MeV SIMS, biological samples, sub-micron resolution]]></keywords_en><summary_hr><![CDATA[Određivanje molekularnog sastava na staničnom nivou važno je za razumjevanje biokemijskih procesa unutar stanica a time i za istraživanje nastanka pojedinih bolesti. Jedna od obećavajućih masenih spektrometrija za 2D molekularno mapiranje na staničnom nivou je i MeV SIMS, spektrometrija sekundarnih molekularnih iona pomoću iona MeVskih energija koja je 2013. instalirana na ionskoj mikroprobi akceleratora u Zagrebu. Nedavno je pokazano da je s trenutnim eksperimentalnim postavom moguće postići 2D mapiranje molekula unutar stanice s lateralnom razlučljivošću ispod jednog mikrometra. Ipak, puni potencijal metode moglo bi se ostvariti samo korištenjem najtežih iona (npr I, Au) energija oko 30 MeV-a, što u postojećem MeV SIMS sustavu na ionskoj mikroprobi IRB-a nije moguće zbog ograničenja u potrebnim magnetskim poljima ionsko-optičkih elemenata. Naime od ranije je poznato da prinos sekundarnih molekularnih iona jako ovisi o elektronskoj zaustavnoj moći iona koji se koriste kao pobuda, te je znatno veći ako se koriste teški ioni visokih energija. Visoka vjerojatnost ovih procesa omogućila bi da se umjesto složenog sustava fokusirajućih leća ionski snop kolimira na mikronske dimenzije pomoću staklene kapilare. Nova kapilarna mikroproba za MeV SIMS koja bi u potpunosti bila optimizirana za 2D mapiranje bioloških materijala bi zbog svoje jednostavnosti mogla biti u daleko široj primjeni posebno na akceleratorima koji nemaju složene i skupe sustave za fokusiranje iona. Također, kapilarna mikroproba sa masenim spektrometrom bit će izgrađena na centralnoj eksperimentalnoj liniji 6.0 MV tandem akceleratora IRB-a te bi se tako minimizirale i teškoće zakretanja ionskog snopa u skretnom magnetu. Na taj način dobio bi se uređaj koji bi i po lateralnoj razlučljivosti i po prinosu sekundarnih molekularnih iona bio superioran u odnosu na postojeće slične uređaje za masenu spektrometriju bioloških materijala.]]></summary_hr><summary_en><![CDATA[Determination of the molecular composition at the cellular level is important to understand the biochemical processes within the cells and thus to explore the occurrence of certain diseases. One of the promising mass spectrometry methods for 2D molecular mapping at the cellular level is MeV SIMS, spectrometry of secondary molecular ions using MeV ions that was installed in 2013 at the ion microprobe in Zagreb. Recently we have demonstrated that with the current experimental setup we can achieve 2D imaging of molecular distribution within the cell with the sub-micron later resolution. However, the full potential of the method could only be achieved by using heavier ions such as I or Au with energies up to 30 MeV, which is presently not possible in the current MeV SIMS setup due to the limitations in the required magnetic fields in the ion-optical elements. It is already known that the secondary molecular ion yield strongly depends on the electronic stopping power of the used ions which increases significantly for heavier high energy ions. High probability of these processes allow us that instead of a complex system of focusing lenses ion beam can be collimated to micron dimensions by using glass capillaries. New capillary microprobe for MeV SIMS that would be fully optimised for 2D mapping of biological samples due to its simplicity could be very interesting at accelerators facilities that do not have complex and expensive systems for ion focusing. Also, capillary microprobe mass spectrometer will be mounted in the central experimental line of the 6.0 MV tandem accelerator RBI in order to minimise the difficulties of turning ion beam to the other beam lines. In this way the setup can be obtained with the lateral resolution and secondary ion molecular yields that is superior to the existing similar setups for mass spectrometry of biological materials.]]></summary_en></project><project>
<id>4043</id><title_hr><![CDATA[Ekonomski temelji hrvatske književnosti ]]></title_hr><title_en><![CDATA[Economic Foundations of Croatian Literature]]></title_en><user_id>19057</user_id><user_firstLast_name>Maša Kolanovic</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-2613</code><acronim><![CDATA[ETHK/EFCL]]></acronim><duration>01.03.2017 - 29.02.2020</duration><status>Završio</status><financ_value>45.292,99 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filologija, Povijest, Znanost o umjetnosti, Etnologija i antropologija, </scie_field_hr><scie_field_en>Philology, History, Arts, Ethnology and anthropology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>17880, 3794, 4485, 19280, 13767, 5027, 19338, 3595, 19133, 19050, 4929, </team_members_id><team_members_names><![CDATA[Krešimir Nemec, JASNA HORVAT, Tatjana  Jukić Gregurić, Maciej Falski, Helena Sablić Tomić, Cvijeta Pavlović, Marijana  Hameršak, Danijela Lugarić Vukas, Ivana Drenjančević, Lana Molvarec, Stipe  Grgas Mufa, ]]></team_members_names><keywords_hr><![CDATA[hrvatska književnost, ekonomija, kultura, ekonomske reprezentacije, ekonomsko polje]]></keywords_hr><keywords_en><![CDATA[Croatian literature, Economy, Culture, Economic representations, Economic field ]]></keywords_en><summary_hr><![CDATA[Projektni prijedlog pod nazivom &#39;&#39;Ekonomski temelji hrvatske književnosti&#39;&#39; ima za cilj stvaranje temeljnih znanja za istraživanje odnosa ekonomije i hrvatske književnosti kroz različita razdoblja hrvatske književne povijesti. Ekonomiju ovdje shvaćamo u širem značenju područja i praksi proizvodnje, potrošnje, distribucije i trgovine iako će samo istraživanje obuhvatiti i odnos hrvatske književnosti i ekonomske znanosti kao njegove integralne sastavnice na metodološkom i tematskom planu. Trenutno stanje u istraživanom području u Hrvatskoj bilježi nepostojanje i nedovoljnu zastupljenost istraživanja ove problematike stoga bi važan doprinos ovog projekta bio sustavno istraživanje odnosa ekonomije i hrvatske književnosti koje bi za rezultat imalo inauguraciju ove problematike u domaćem istraživačkom prostoru, stvaranje temelja za njezino sustavno istraživanje te šire prepoznavanje njezine nacionalne relevantnosti i međunarodne kompetitivnosti. Predloženo istraživanje bi izradilo interdisciplinarni metodološki okvir za pristup navedenoj problematici koji bi na relevantan i svrhovit način povezivao znanja filološke, kulturološke i ekonomske analize s kojim bismo zatim pristupili bogatom hrvatskom književnom arhivu povezanom s ekonomskim temama i procesima kroz tri jasno određena problemska fokusa istraživanja, a to su: 1. Istraživanje ekonomskih reprezentacija u tekstovima hrvatske književnosti, 2. Istraživanje pozicije hrvatske književnosti kao institucije u ekonomskom polju i 3. Istraživanje analogija između diskurzivnosti hrvatske književnosti i ekonomije. Jedinstveni doprinos ovog projekta bi bio: 1)  stvaranje interdisciplinarnog metodološkog okvira i 2) primjena novog metodološkog okvira na bogat književni arhiv što bi za rezultat imalo relevantnu artikulaciju ove problematike u hrvatskom istraživačkom prostoru te stvaranje temelja za njezino istraživanje.]]></summary_hr><summary_en><![CDATA[The project proposal “Economic Foundations of Croatian Literature” has the objective of the development of fundamental knowledge for the research of the relationship between economy and Croatian literature over different periods of Croatian literary history. In this case, the term economy is broadly understood as the field and practice of production, consumption, distribution and merchandise. The research will also include the relationship between Croatian literature and economics, as its constitutive component on a methodological, as well as a thematic level. The current state of research is marked by the absence or marginal interest in the above mentioned issues. Therefore, the important contribution of this project would be the inauguration of this research subject into a national research area, by creating a basis for its systematic research and by broadening its recognition as a nationally relevant and internationally competitive field of research. The proposed project aims to construct an interdisciplinary methodological framework that would link philological, cultural and economic analyses and approaches in a relevant and purposeful way. The plentiful Croatian literary archive of economic phenomena and processes will be accessed within this framework with three clearly defined analytical research focuses which are as follows: 1. Research of economic representations in Croatian literary texts; 2. Research of the position of Croatian literature as an institution in the economic field and 3. Research of analogies between the discourses of Croatian literature and economics. The unique contribution of this project would be 1) the creation of an interdisciplinary methodological framework and 2) implementation of the new methodological framework on the rich literary archive that would result with the created foundations for its research in the Croatian scientific environment.]]></summary_en></project><project>
<id>4045</id><title_hr><![CDATA[Sonoelastografija i magnetska rezonancija u dijagnostici i liječenju karcinoma dojke]]></title_hr><title_en><![CDATA[Sonoelastography and magnetic resonance imaging in diagnosis and treatment of breast cancer]]></title_en><user_id>7350</user_id><user_firstLast_name>Boris Brkljačić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-2997</code><acronim><![CDATA[EL-MRI-BREAST]]></acronim><duration>20.03.2017 - 19.03.2022</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Clinical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>19193, 19192, 19226, 5927, 6702, 19251, 19159, 3973, 28888, 28875, </team_members_id><team_members_names><![CDATA[Renata Huzjan Korunić, Rado Žic, KREŠIMIR MARTIĆ, Tajana Štoos-Veić, Čedna Tomasović-Lončarić, Niko Radovic, Eugen Divjak, Gordana Ivanac, Vanja Posavec, Iva Biondić Špoljar, ]]></team_members_names><keywords_hr><![CDATA[ultrazvuk, sonoelastografija, magnetska rezonancija, karcinom dojke, dijagnostika, liječenje]]></keywords_hr><keywords_en><![CDATA[ultrasound, sonoelastography, magnetic resonance imaging, breast cancer, diagnosis, treatment]]></keywords_en><summary_hr><![CDATA[Kvalitativne i kvantitativne osobine različitih lezija dojke dobivenih oslikavanjem sonoelastografijom i magnetskom rezonancijom (MRI) uz primjenu kontrasta biti će uspoređene s nalazima core-biopsije i finalnim poslijeoperacijskim histopatološkim nalazima. Ciljevi su: (1) ustanoviti shear-wave elastografske (SWE) osobine lezija u dojkama i ispitati razlike među in-situ i invazivnim karcinomima stratificiranim prema histopatološkom stupnju (gradusu) i imunohistokemijskom fenotipu, pokazateljima agresivnosti i prognoze karcinoma. Ultrazvučni uređaj nema ograničenje mjerenja maksimalne elastičnosti od 180 kPa, što omogućuje procjenu stvarnih vrijednosti tvrdoće invazivnih karcinoma; (2) Usporediti SWE parametre s morfološkim svojstvima lezija na MRI, obrascima nakupljanja kontrasta na MRI, nalazima difuzijskog MRI oslikavanja i histopatološkim osobinama karcinoma i drugih lezija dojke; (3) ispitati doprinos SWE kao dopune konvencionalnom, B-mode UZV i kontrastnom UZV pri odabiru lezija za biopsiju i procijeniti može li SWE smanjiti stopu potcjenjivanju (underestimation) lezija u uzorku core-biopsije prilikom biopsija lezija pod ultrazvučnim nadzorom, na način da prikaže najtvrđa područja koja treba bioptirati kod sonomorfološki neodređenih lezija; (4) ispitati utjecaj SWE i MRI nalaza na izbor vrste kirurškog zahvata ili odabir neoadjuvantne kemoterapije, te na praćenje odgovora karcinoma dojke na kemoterapiju; (5) ustanoviti SWE i MRI osobine recidiva karcinoma nakon poštednih operacija i onkoplastičnih rekonstrukcija dojke miokutanim režnjevima, te ustanoviti je li SWE bolje od konvencionalnog ultrazvuka korelira s MRI nalazima i može li tako usmjeriti izvođenje biopsije; (6) ustanoviti SWE osobine lezija tijekom ciljanog („second-look“) ultrazvučnog pregleda nakon pozitvnog nalaza MRI dojke, te procijeniti može li SWE modificirati odluku o izvođenju biopsije i promijeniti područje izvođenja biopsije.]]></summary_hr><summary_en><![CDATA[Qualitative and quantitative sonoelastographic and contrast-enhanced magnetic resonance imaging (MRI) features of breast lesions will be compared to the core-biopsy and final postoperative histopathologic findings. Objectives are: (1) To determine shear-wave elastographic (SWE) features of breast lesions and to investigate the differences in in-situ and invasive cancers stratified by the histopathologic grade and immune-histochemical phenotype, which are biomarkers of aggressiveness and prognosis. Ultrasound scanner will be used without capped upper maximum elasticity value of 180 kPa, allowing realistic evaluation of the stiffness of invasive cancers; (2) To correlate SWE parameters, with MRI morphologic features, MRI enhancement patterns, MRI diffusion weighted findings and histopathologic features of cancers and other breast lesions; (3) To determine the impact of the SWE addition to the gray scale and contrast-ehnanced US on the selection of lesions for biopsy and to evaluate ability of SWE to reduce the rate of underestimation of lesions on core-biopsy specimen obtained by US-guided biopsy, by demonstrating the stiffest area for biopsy in undetermined lesions; (4) To explore the impact of SWE features and MRI features on the choice of operative treatment or neoadjuvant chemotherapy and on the monitoring and prediction of breast cancer response to neoadjuvant chemotherapy and to evaluate if SWE is comparable to MRI in prediction of the cancer response to neoadjuvant chemotherapy; (5) To determine SWE and MRI features of recurrent cancer after breast conserving surgery and breast reconstructions with myocutaneous flaps, to demonstrate if SWE better correlates than gray-scale US to MRI findings of recurrence, and thus can target biopsy; (6) To determine SWE features of lesions examined at “second-look” targeted US after positive MRI findings to evaluate whether the addition of SWE to gray-scale US can modify decision to biopsy and to change the extent of biopsy.]]></summary_en></project><project>
<id>4046</id><title_hr><![CDATA[Uloga proteina Spartan u DNA replikaciji]]></title_hr><title_en><![CDATA[The role of Spartan in DNA replication]]></title_en><user_id>7349</user_id><user_firstLast_name>Ivana Marinović Terzić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-3097</code><acronim><![CDATA[SprtnRep]]></acronim><duration>01.09.2017 - 28.02.2022</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Split School of Medicine]]></institution_en><team_members_id>9932, 5769, 6130, 19252, 25210, 28748, </team_members_id><team_members_names><![CDATA[Kristijan  Ramadan, Janoš  Terzić, Matilda Šprung, Jasminka Omerović, Anja Ančić, Mateo Glumac, ]]></team_members_names><keywords_hr><![CDATA[Spartan, DVC1, DNA replikacija, DNA popravak, metaloproteazna domena, hepatocelularni karcinom ]]></keywords_hr><keywords_en><![CDATA[Spartan, DVC1, DNA replication, DNA repair, metalloprotease domain, hepatocellular carcinoma]]></keywords_en><summary_hr><![CDATA[Stabilnost kromosoma tijekom replikacije i popravka DNA je presudna za sprečavanje patološke transformacije stanica. Nedostatnosti DNA popravka uzrokuju razvojne anomalije, preuranjeno starenje (progeriju) i rak. Većina DNA oštećenja blokira napredovanje replikacijske viljuške, jer DNA polimeraza ne može prepoznati oštećene nukleotide. Na takvim mjestima, ubikvitinacija replikacijskog proteina PCNA, koji kao stezaljka kliže po DNA molekuli, pokreće mehanizam  translezijske DNA sinteze (TLS). Nedavno smo identificirali nasljednu mutaciju gena SPRTN (Spartan) kod tri bolesnika, koji su razvili progeroidni sindrom karakteriziran genomskom nestabilnosti i razvojem hepatocelularnog karcinoma (HCC) u mladosti. Druge grupe su pokazale da ja Spartan važan za aktivaciju TLS (Ghosal et al, 2012; Kim i sur, 2013). Naši rezultati pokazuju da Spartan igra važnu ulogu u normalnoj replikaciji DNA, sprečavajući replikacijski stres i održavajući stabilnosti genoma (Marinović-Terzić et al, 2014). U ovom projektu predlažemo da je Spartan metaloproteaza važna za uklanjanje kovalentno vezanih proteina i DNA, čime se omogućava napredovanje replikacijske viljuške.	Cilj ovog projekta je:1. Definirati funkciju Spartan domena,2. Odredite interakcijska svojstva / partnere proteina Spartan3. Opisati dinamiku procesa popravka DNA oštećenja u stanicama bez proteina SpartanVećina tehnika koje ćemo koristiti u ovom radu su uvriježene u našim laboratorijima: Western blot, IP, GST-pulldown, Imunofluorescentna mikroskopija, RNAi, SILAC bazirana masena spektrometrije i protočna citometrija. Koristit ćemo i jednu novu tehniku - CRISPR / Cas9 ciljano preuređivanje gena. Svi pokusi će se raditi na kulturama stanica. Ovaj projekt ima potencijal za generiranje vrlo zanimljivih rezultata i visoku vjerojatnost publiciranja u vrhunskim znanstvenim časopisima. Rezultati ovog projekta će bolje razjasniti specifičnu ulogu proteina Spartan u DNA replikaciji i održavanju genomske stabilnosti.]]></summary_hr><summary_en><![CDATA[The maintenance of chromosomal stability during DNA replication and repair is crucial for preventing patogenic transformation of a cell. Defects in DNA repair cause developmental abnormalities, premature aging, and cancer. Most types of DNA damage block the progression of replication forks, because DNA polymerases cannot recognize damaged nucleotides. At sites of stalled DNA replication fork, replication sliding clamp protein PCNA becomes ubiquitinated and thus initiates translesion DNA synthesis (TLS). Recently, we have identified germline mutations in SPRTN gene (Spartan) in three patients, who developed progeroid syndrome characterized by genomic instability and early onset hepatocellular carcinoma (HCC). Previously it was proposed that Spartan is important for activation of TLS (Ghosal et al, 2012; Kim et al, 2013). Our results show that Spartan plays an essential role in normal DNA replication by preventing DNA replication-stress and maintaining genome stability (Marinovic-Terzic et al, 2014). Here we propose that Spartan is a metaloprotease important for removal of DNA-protein crosslinks, thus enabling the progression of replication forks. Our goal in this project is to:1. Define the functions of Spartan’s domains, 2. Determine Spartans interacting properties/partners, and 3. Describe the dynamics of a DNA damage repair process in Spartan depleted cells. Most of the techniques we will use in this work are established procedures in our laboratories: Western blot, IP, GST-pull down, immunofluorescent microscopy, RNAi, SILAC based mas spectrometry and flow cytometry. One novel technique will be used as well – CRISPR/Cas9 targeted gene editing. All experiments will be performed using cultured cells. This project proposal has a potential to generate very interesting results with high possibility for publications in top scientific journals. Results of this project will help to better understand the specific role of Spartan in DNA replication and genome stability.]]></summary_en></project><project>
<id>4048</id><title_hr><![CDATA[Između istoka i zapada – dolina rijeke Cetine kao komunikacijska poveznica tijekom prapovijesti i antike]]></title_hr><title_en><![CDATA[Where East Meets West – The Cetina River Valley as an Ancient Pathway of Communication (Cetina Valley Survey)]]></title_en><user_id>19187</user_id><user_firstLast_name>Helena Tomas Bakota</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-1478</code><acronim><![CDATA[CeVaS]]></acronim><duration>03.04.2017 - 17.10.2024</duration><status>Završio</status><financ_value>79.633,69 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Arheologija, Povijest, Etnologija i antropologija, </scie_field_hr><scie_field_en>Archeology, History, Ethnology and anthropology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>13548, 6011, 4028, 19516, 19537, 19547, 19557, 7522, 7551, 13192, 25379, 8198, </team_members_id><team_members_names><![CDATA[Tihomila Težak-Gregl, Kornelija Jurin Starčević, Mirjana Sanader, Matija Dronjić, Eleonora Ballan, Giulia Recchia, Maja Gori, Marina Milićević Bradač, Zrinka Šimić-Kanaet, Danijela Roksandić, Jura Triplat, Marcel Burić, ]]></team_members_names><keywords_hr><![CDATA[dolina rijeke Cetine, komunikacijski putevi, prapovijest, antika, naselja, grobnice, trgovačka razmjena, terenski pregled]]></keywords_hr><keywords_en><![CDATA[Cetina River Valley, communication pathway, prehistory, antiquity, settlement pattern, burials, trade and exchange, survey]]></keywords_en><summary_hr><![CDATA[U rano brončano doba u dolini Cetine razvila se cetinska kultura čije se odlike mogu naći po cijelom jadranskome bazenu, Malti i u Grčkoj. Stoga se s pravom može reći da je cetinska kultura predstavljala najznačajniju epohu prapovijesnoga života u dolini; ona ukazuje da su njeni nosioci mogli ostvariti kontakte s udaljenim krajevima. Rijeka Cetina, koja je u nekim svojim dijelovima plovna, pri tim je putovanjima vjerojatno služila kao važan put. Usprkos tako profitabilnoj komunikaciji koja je dolinu povezivala s Jadranom i vibrantnim Sredozemljem, razdoblja prije i nakon cetinske kulture nisu bila podjednako napredna. Jedan od ciljeva projekta jest ustanoviti koji su faktori utjecali na te varijacije kroz vrijeme. Također se namjeravaju utvrditi stupnjevi važnosti doline kao mjesta obitavališta i komunikacijskih puteva kroz prapovijesna i povijesna razdoblja. Ovi bi se ciljevi ostvarili metodom arheološkog rekognosciranja (terenskog pregleda) ciljano odabranih dijelova cetinske doline. Očekuje se da će otkriveni materijal ukazati na intenzitet naseljavanja doline u pojedinim razdobljima, ali i na intenzitet kontakata s ostalim, pogotovo udaljenijim područjima, pa će nam tako i odgovoriti na pitanja do koje je mjere u određenom razdoblju dolina bila izolirana ili pak otvorena vanjskome svijetu. Usporedbe s recentnijim epohama i događajima mogu ukazati na prednosti koje pruža život u tako plodnome okružju, ali isto tako i na nedostatke uvjetovane činjenicom da je cetinska dolina važna poveznica unutrašnjosti Balkanskoga poluotoka i Jadranskoga mora, pa je tako bila metom brojnih sila i poprištem čestih sukoba i ratova. Činjenica da je rimska legija nekoć bila stacionirana upravo u ovoj dolini (rimski vojni logor kod Trilja) govori nam da su slični problemi i sukobi život u dolini ugrožavali i u davnijoj prošlosti. Podaci prikupljeni predloženim rekognosciranjem zasigurno će pružiti bogatstvo novih arheoloških i povijesnih svjedočanstava o dolini Cetine.]]></summary_hr><summary_en><![CDATA[During the Early Bronze Age a culture developed in the Cetina Valley – the Cetina Culture – whose features over time got distributed in the Adriatic basin, Malta and Greece. That culture was a prehistoric highlight of the valley and demonstrated that its inhabitants were capable of establishing far-reaching contacts; the Cetina river, navigable at some parts, may have in that process served as a crucial communication channel. Despite this beneficial river giving access to the Adriatic sea and the vibrant Mediterranean basin, periods prior or posterior to the Cetina Culture were not equally prominent. The project seeks to explore the factors that may have influenced such a diachronic variation. Also, it aims to establish degrees of general importance of the valley as a place of habitation and communication through prehistoric and historic times. These goals will be achieved by archaeological surveying of the purposefully selected parts of the valley. The material recovered during surveying is expected to give an insight into the level of intensity of habitation of the area through time, as well as the intensity of foreign contacts (i.e. the isolation of the valley versus its receptiveness of the outside world). Comparisons to more recent periods or episodes may highlight the advantages of living in a very fertile environment, but also disadvantages caused by the role of the Cetina Valley as a transit zone from the inner Balkan peninsula to the open sea. As such, the valley has been a stage of numerous conflicts and wars. The fact that a Roman legion was once settled in the Valley (the fort of Tilurium) testifies that conflicts may have disturbed the life in the valley even in a more distant past. In brief, data obtained through a systematic archaeological survey will certainly reveal valuable archaeological and historical testimonies, but will also enhance the awareness of present local communities of the rich past of the valley.]]></summary_en></project><project>
<id>4051</id><title_hr><![CDATA[ &#39;&#39;Hrvatski glazbeni i liturgijski kodeksi srednjega vijeka: Interdisciplinarna obrada“ ]]></title_hr><title_en><![CDATA[&#39;&#39;Croatian musical and liturgical medieval codices: Interdisciplinary research“ ]]></title_en><user_id>11216</user_id><user_firstLast_name>Hana Breko Kustura</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-6619</code><acronim><![CDATA[CROMUSCODEX70]]></acronim><duration>01.04.2017 - 31.12.2021</duration><status>Završio</status><financ_value>51.173,93 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Znanost o umjetnosti, Teologija, Filologija, Povijest umjetnosti, </scie_field_hr><scie_field_en>Arts, Theology, Philology, Art history, </scie_field_en><institution_hr><![CDATA[Hrvatska akademija znanosti i umjetnosti]]></institution_hr><institution_en><![CDATA[Croatian Academy of Sciences and Arts]]></institution_en><team_members_id>7861, 19430, 19071, 5685, </team_members_id><team_members_names><![CDATA[Marijana Horvat, Domagoj Volarević, Katarina Livljanić, Rozana Vojvoda, ]]></team_members_names><keywords_hr><![CDATA[srednjovjekovni rukopisi,glazba, liturgija, iluminacije, hrvatska glazba srednjega vijeka]]></keywords_hr><keywords_en><![CDATA[medieval manuscripts, music, liturgy, illuminations, Croatian music of the Middle Ages]]></keywords_en><summary_hr><![CDATA[Projekt &#39;&#39;Hrvatski glazbeni i liturgijski kodeksi srednjega vijeka: Interdisciplinarna obrada“  se bavi interdisciplinarnom obradom liturgijskih i glazbenih kodeksa hrvatskih zemalja u razdoblju od 11. do 17. stoljeća pohranjenih u stranim i domaćim arhivima. To je premijerni pothvat istodobnog rada muzikologa, filologa, liturgičara i povjesničara umjetnosti specijaliziranih za dokumente srednjovjekovne hrvatske glazbe,  pisane riječi,  liturgije i likovnosti. Cilj je komparativna usporedba znanih hrvatskih izvora sa europskim rukopisma i otkriće njihova stvarnog eklezijastičkog porijekla i identiteta koja do danas u većem broju izvora nije poznat. Većina je izvora pohranjena u crkvenim arhivima Hrvatske, no dvadesetak kodeksa se danas čuvaju u  stranim bibliotekama. Ovi izvori trebaju postati dio komparativnih istraživanja. Glazbeni i liturgijski kodeksi koji datiraju od 11. stoljeća naovamo  predstavljaju najraniji sloj izvora hrvatske pismenosti, liturgije i glazbe, koji tek postupno trebaju ući u europske znanstvene publikacije. Projekt se temelji na suvremenim metodama poredbenog istraživanja, transkripcije i transliteracije izvora, rekonstrukcije glazbe iz neumama notiranih kodeksa, teži aktualnom prikazu novih rezultata europskoj i domaćoj znanstvenoj sredini, kao i diseminaciji istih u vidu znanstvenih radova, notnih izdanja-transkripcija i prezentacije na domaćim i međunarodnim znanstvenim simpozijima i radionicama za studente, te audio i video zapisima.]]></summary_hr><summary_en><![CDATA[Project &#39;&#39;Croatian musical and liturgical medieval codices: interdisciplinary research“  deals with interdisciplinary investigation of the liturgical and musical codices of Croatian lands in the period from 11th to 17th century stored in domestic and foreign archives. This is a premier research done simultaneously by musicologists, philologists, liturgists and art historian specializing in medieval documents of Croatian music, written word, liturgy and the arts. The main goal is the investigation of the origin of the Croatian codices in comparison with similar European ones, and discovery of their real ecclesiastical origin and identity. In most cases the real origin and “destination” where the particular chant manuscript was used is still not known. Most of the sources are kept today in the church archives in  Croatia. However, there are around twenty of them stored in foreign archives and libraries. These sources will be used in the comparative research. Musical and liturgical codices dating from the 11th century onward represent the earliest layer of Croatian literacy, liturgy and music, which only gradually have to enter into the European scientific publications. The project is based on modern methods of comparative research, transcription and transliteration of particular Beneventan and Carolingian sources, reconstruction of music from a neumatic musical  notation to the modern, in order to present the new results to the wider European and national scientific environment. Our goal is a dissemination of the results in the form of scientific papers, sheet music-transcriptions and presentations of the most important discoveries  at national and international scientific symposia and workshops.The other part of the project is the research and preparation of the scientific platform  for the new audio and video recordings of the medieval music repertory from Croatian musical sources up to date completely unknown.]]></summary_en></project><project>
<id>4059</id><title_hr><![CDATA[Određivanje ključnih molekula epitelno-mezenhimalne tranzicije kao mogućih ciljeva za terapiju raka jajnika ]]></title_hr><title_en><![CDATA[Drug-induced epithelial-mesenchymal transition in ovarian cancer therapy]]></title_en><user_id>3713</user_id><user_firstLast_name>Anamaria Brozović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-1036</code><acronim><![CDATA[DEvOuT]]></acronim><duration>10.07.2017 - 09.06.2022</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>17888, 19663, 19635, 19706, 12695, 5551, 19664, 25301, 25314, 23892, </team_members_id><team_members_names><![CDATA[Sanja Dabelić, Zoran Culig, Darija Stupin Polančec, Martin Puhr, Slavko Orešković, Vladimir Banović, Ivan Babić, Margareta Pernar, Juran Kralj, Marija Milković Periša, ]]></team_members_names><keywords_hr><![CDATA[Epitelno-mezenhimalna tranzicija, otpornost na lijekove, rak jajnika, miRNA-200, karboplatina]]></keywords_hr><keywords_en><![CDATA[epithelial-mesenchymal transition, drug resistance, ovarian cancer, miRNA-200, carboplatin]]></keywords_en><summary_hr><![CDATA[U najvećem broju slučajeva rak jajnika dijagnosticira se u uznapredovalom stadiju zbog čega je kemoterapija neuspješna. Kod bolesnica koje odgovore uspješno na terapiju čak u 70-80% bolest se ponovo javlja unutar godine dana. Prema tome, razvoj otpornosti na terapiju glavna je prepreka njene uspješnosti. Karboplatina (CBP) je jedan od lijekova prve linije terapije. Proces epitelno-mezenhimalna tranzicija (EMT) korelira s napredovanjem bolesti i metastaziranjem te otpornosti na terapiju. Literaturni podaci opisuju promjene različitih proteina i miRNA u tim procesima. Međutim, još uvijek nije poznato koje od tih molekula su uključene u oba procesa. U okviru naših preliminarnih istraživanja razvili smo nekoliko staničnih linija raka jajnika otpornih na CBP koje su prošle proces EMT, te u jednoj od njih identificirali smanjenu ekspresiju svih članova miRNA-200 obitelji za koje se iz literature zna da reguliraju ekspresiju mnogih proteina u stanici. Budući da se proces EMT i razvoj otpornosti događaju istovremeno naša je hipoteza da postoje ključne molekule koje se uključene u oba procesa te da bi se one mogle koristiti kao ciljne molekule za terapiju. Prvi cilj ovog projekta je u in vitro modelima kulture stanica pronaći ključne molekule (proteine na transkripcijskom i translacijskom nivou i miRNA) odgovorne za EMT i razvoj otpornosti na CBP i njihovu međusobnu povezanost. Uključenost svake od pronađenih molekula utvrdit će se odgovarajućim funkcionalnim testovima. Drugi cilj je utvrditi ekspresijski status pronađenih molekula u uzorcima tkiva bolesnica (normalno vs tumorsko) te korelirati pronađene promjene s odgovorom bolesnica na terapiju. Treći cilj je potvrditi važnost otkrivenih molekula u regulaciji EMT i razvoju otpornosti na CBP u modelu organoida. Ukupni cilj projekta je pronaći ključne molekule odgovorne za EMT i otpornost na CBP, te moguće korištenje tih molekula u  liječenju bolesnica oboljelih od raka jajnika.]]></summary_hr><summary_en><![CDATA[Most epithelial ovarian cancer patients are diagnosed with advanced-stage disease and do not respond to chemotherapy. About 70-80% of patients, who respond to the chemotherapy, experience a recurrence of cancer within months to years. Therefore the development of tumor drug resistance is the major problem for a successful therapy. Carboplatin (CBP) is one of the drugs in the first-line therapy. Epithelial-mesenchymal transition (EMT) correlates with cancer progression, metastasis and drug resistance. Literature data have shown changes in expression of different proteins and miRNA in these processes. However, it is still not known which molecules are involved in both of these processes. Our preliminary research resulted in establishment of several CBP resistant ovarian cancer cell lines that underwent EMT. In one of these cell lines we found decreased expression of miRNA-200 members, for which it has been known to regulate many different proteins in the cells. Since EMT and development of drug resistance have been shown to occur in the cell simultaneously, our hypothesis proposes the existence of key molecules involved in both of these processes making them valuable therapy targets. The first goal of this project is to determine key molecules (proteins at transcriptional and translation levels and miRNA) involved in EMT and development of drug resistance and to confirm their role by using functional tests. The second goal is to establish the expression pattern of these molecules in tissue samples from patients with ovarian cancer (normal vs tumor) and to correlate these changes with the patient response to the therapy. The third goal is to confirm the importance of identified molecules in EMT and drug resistance development by using organoids culture. The overall goal of this project is to find key molecules involved in EMT and development of drug resistance and to investigate the possibility of using them as targets for ovarian cancer therapy.]]></summary_en></project><project>
<id>4060</id><title_hr><![CDATA[DNA kao dokaz o distribuciji i vitalnosti ugrožene balkanske divokoze]]></title_hr><title_en><![CDATA[DNA as evidence of distribution and vitality of endangered Balkan chamois]]></title_en><user_id>2954</user_id><user_firstLast_name>Nikica Šprem</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-5751</code><acronim><![CDATA[BalkCham]]></acronim><duration>01.03.2017 - 29.02.2020</duration><status>Završio</status><financ_value>96.857,87 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, Biotehnologija, </scie_field_hr><scie_field_en>Agriculture, Biotechnology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Agronomski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Agriculture]]></institution_en><team_members_id>6460, 19944, 19869, 20237, 25111, 25184, 25973, 25076, </team_members_id><team_members_names><![CDATA[Magda Sindičić, Elena Bužan, Toni Safner, Peter Lazar, Sunčica Stipoljev, Laura Iacolina, Toni Tešija, Andrea Rezić, ]]></team_members_names><keywords_hr><![CDATA[R. rupicapra balcanica, SNP, MHC, efektivna veličina populacije, inbreeding, populacijska struktura, Dinarske planine]]></keywords_hr><keywords_en><![CDATA[R. rupicapra balcanica, SNP, MHC, effective population size,  inbreeding, population structure,Dinaric mountains]]></keywords_en><summary_hr><![CDATA[Model vrsta projektnog prijedloga je balkanska divokoza (R. rupicapra balcanica), populacija sjeverozapadnih Dinarida u Hrvatskoj. Kao karizmatični papkar, balkanska divokoza, vodeća je vrsta kod očuvanja planinskog ekosustava Balkanskog poluotoka koji je jedan od 35 svjetski važnih lokaliteta biološke raznolikosti. Zbog mala veličina populacije i niska genetska varijabilnost populacija divokoza u Dinaridima podložna je mnogim čimbenicima. Sa svim dosadašnjim spoznajama, glavni cilj našeg projekta je analizirati genetsku strukturu balkanske divokoze, koristeći neutralni (SNP) biljeg i biljeg pod selekcijom (MHC kompleks) za procjenu statusa zaštite i proučiti mehanizme molekularne adaptaciji lokalne populacije. Nadalje, ekstrakcija DNA iz lubanja divokoza odstrjeljenih prije reintrodukcije i usporedba uspješnih sekvenci sa današnjim iz genske banke, te potencijalno rekonstruirati filogeografiju divokoza s Velebita. Okolišna i staništa analiza u GIS-u  provest će se analizom prisutnosti i godišnje migracije životinja. Sve to će se postići interdisciplinarnim istraživačkim timom sastavljenim od agronoma, biologa, šumara i veterinara. Rezultati našeg projekta će pružiti uvid u distribuciju i vitalnost, što je važno u uspostavljanju učinkovitog upravljanja buduće populacije divokoza u Dinaridima. Isto tako moramo biti svjesni da je biološka raznolikost kulturna baština stoga nam je dužnost zaštititi balkansku divokozu za buduće generacije.]]></summary_hr><summary_en><![CDATA[The model species of the project proposal is Balkan chamois (R. rupicapra balcanica), specifically population of the northwestern Dinaric Mountains in Croatia. As a charismatic ungulate, Balkan chamois, is an excellent flagship species for the conservation of the montane ecosystems of the Balkan Peninsula which is one of the world’s 35 biodiversity hotspots. The small population size and low genetic variability of the chamois populations in the Dinaric Mountains make them vulnerable to many factors. With all previous findings considered, main goal of our project is to analyse genetic structure of Balkan chamois, using neutral (SNP) and loci under selection (MHC complex) to estimate conservation status and to study mechanisms of molecular adaptation of local populations. Furthermore, DNA extraction from hunted chamois before reintroduction and comparison of successful sequences with contemporary ones from Gen bank, and potential reconstruction of phylogeography of chamois from Velebit Mountain. An environmental and habitat analyses in GIS will carry out to analysis of habitat occupation and annual migration of animals. This will be achieved by interdisciplinary research team composed of agronomist, biologists, forester and veterinarians. Results of our project will provide insights of distribution and vitality, what is important in establishment of the effective future management of chamois population in Dinaric Mountains. Also we must be aware that biodiversity is a cultural heritage and it is important to protect Balkan chamois for future generations.]]></summary_en></project><project>
<id>4061</id><title_hr><![CDATA[Proizvodnja željeza uz rijeku Dravu u antici i srednjem vijeku: stvaranje i transfer znanja, tehnologija i roba]]></title_hr><title_en><![CDATA[Iron production along the Drava River in the Roman period and the Middle Ages: Creation and transfer of knowledge, technologies and goods]]></title_en><user_id>7810</user_id><user_firstLast_name>Tajana Sekelj Ivančan</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-5047</code><acronim><![CDATA[TransFER]]></acronim><duration>01.03.2017 - 30.09.2021</duration><status>Završio</status><financ_value>79.633,69 eur</financ_value><scie_area_hr>Humanističke znanosti, Prirodne znanosti, Tehničke znanosti, </scie_area_hr><scie_area_en>Humanities, Natural sciences, Technological sciences, </scie_area_en><scie_field_hr>Arheologija, Geofizika, Metalurgija, Geografija, </scie_field_hr><scie_field_en>Archeology, Geophysics, Metallurgy, Geography, </scie_field_en><institution_hr><![CDATA[Institut za arheologiju]]></institution_hr><institution_en><![CDATA[Institute of Archaeology in Zagreb]]></institution_en><team_members_id>11254, 11265, 19573, 2885, 3030, 12322, 3259, 12371, 12380, 11263, 12457, 6516, 20538, 25295, </team_members_id><team_members_names><![CDATA[Tatjana Tkalčec, Siniša Krznar, Aleksandra Bugar, Sibila Borojević Šoštarić, Stanko Ružičić, Ivan Marija Hrovatin, Ladislav Lazić, Robert Čimin, Ivan Valent, Branko Mušič, Metka Culiberg, Katarina Botić, Tomislav Brenko, Tena Karavidović, ]]></team_members_names><keywords_hr><![CDATA[Proizvodnja željeza, talioničke peći, sirovina, drveni ugljen, Podravlje, socio-kulturološki odnosi ]]></keywords_hr><keywords_en><![CDATA[Production of Iron, Smelting furnaces, Raw Materials, Charcoal, Drava River Valley, Socio-Cultural Relations]]></keywords_en><summary_hr><![CDATA[Cilj projekta je proširiti spoznaje o primarnoj obradi željeza u nizinskom području rijeke Drave te definirati značenje proizvodnje željeza u kontekstu socio-kulturoloških odnosa u različitim povijesnim razdobljima (antika i srednji vijek). Projektni zadaci usmjereni su na važna pitanja: 1. definirati podrijetlo željezne rude i potrebnih resursa (glina, voda, drvo); 2. definirati tehnologiju obrade željezne rude kroz povijesna razdoblja;3. definirati utjecaj proizvodnje željeza u kontekstu socio-kuturoloških odnosa. Važan naglasak u svim fazama projekta stavljen je na interdisciplinarna istraživanja. Provest će se preliminarna istraživanja nizinskog prostora uz rijeku Dravu primjenjujući arheološke, geološke i geofizičke metode. Na temelju dobivenih rezultata poduzet će se uzorkovanje tla radi definiranja izvora sirovine, kao i ciljana arheološka istraživanja na dvije odabrane pozicije. Fokus istraživanja usmjerit će se prema promjenama u tehnologiji obrade željeza kroz primjenu različitih tipova peći u različitim razdobljima. Na uzorcima će se provest arheometalurške i metalografske analize s ciljem dobivanja podataka o tehnologiji prerade rude u određenom razdoblju, ali i njena podrijetla, odnosno veze s geološkom podlogom. Analizom vrste drva, posredno će se dobiti slika krajolika (šume) dravske nizine. Očekuje se da će projekt pružiti nove podatke za razumijevanje promjena u tehnologiji obrade željezne rude koje su se dogodile, primarno, unutar istog prostora kroz vrijeme.Sinergijski efekt interdisciplinarnog istraživačkog tima i sveobuhvatna metodologija omogućit će, kroz praćenje gotovih željeznih proizvoda u svakodnevnici, razumijevanje socioloških i kulturoloških odnosa u nizinskom dravskom prostoru, ali i u širem, srednjeeuropskom kontekstu.Novi podaci bit će prikazani pomoću GIS platforme te time u odgovarajućoj formi javno dostupni za razmatranja prostornih korelacija unutar samih metalurških kompleksa, ali i u odnosu na šire područje.]]></summary_hr><summary_en><![CDATA[The aim of the project is to expand knowledge about the primary processing of iron in the lowland area of the Drava River and to define the significance of iron production in the context of socio-cultural relations in the context of ancient and medieval societies. The project focuses on several important aspects: 1. To define the source of iron ore and necessary resources (clay, water, wood); 2. To define the technology of processing iron ore throughout historical periods; 3. To define the impact of iron production in the context of sociocultural relations. An important emphasis is placed on interdisciplinary research in all phases of the project. Preliminary investigation of the lowlands will be performed using archaeological, geological, and geophysical methods. Soil sampling will take place on the basis of obtained results, as will targeted archaeological excavation at two selected sites. Research will be focused on changes in the technology of iron processing through the used of various kinds of furnaces in different periods. Archaeometallic and metallurgical analyses will be performed on samples to obtain data about the processing of ore in a given period, but also its origin in terms of the geology. Through charcoal analysis, the wood types will indirectly offer information about the then landscape (forests). The project is expected to offer new data for understanding changes in the technology of processing iron ore that occurred within the same area throughout time. The synergistic effect of the interdisciplinary research and the comprehensive methodology will enable, through analysis of the finished everyday iron products, comprehension of social and cultural relations in the lowland Drava valley, but also in a wider, central European context. New data will be presented in a GIS platform, enabling public access to consideration of spatial correlations within the metallurgical complex, but also referring to the broader region.]]></summary_en></project><project>
<id>4064</id><title_hr><![CDATA[Rekonstrukcija prapovijesnog (od neolitika do brončanog doba) načina života na području Hrvatske – multidisciplinarni pristup ]]></title_hr><title_en><![CDATA[Reconstructing prehistoric (Neolithic to Bronze Age) lifestyles on the territory of Croatia – a multidisciplinary approach ]]></title_en><user_id>2670</user_id><user_firstLast_name>Mario Novak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-1450</code><acronim><![CDATA[PASTLIVES]]></acronim><duration>01.04.2017 - 31.03.2021</duration><status>Završio</status><financ_value>78.631,63 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Arheologija, </scie_field_hr><scie_field_en>Archeology, </scie_field_en><institution_hr><![CDATA[Institut za antropologiju]]></institution_hr><institution_en><![CDATA[Institute for Anthropological Research]]></institution_en><team_members_id>19178, 19197, 19174, 19212, 19232, 19225, 1439, 2764, 24314, </team_members_id><team_members_names><![CDATA[Stefano Benazzi, Jacqueline Balen, Tamás Hajdu, Claudio Tuniz, Ron Pinhasi, Sarah McClure, Mislav Čavka, Ivor Janković, Mario Carić, ]]></team_members_names><keywords_hr><![CDATA[prapovijest, Hrvatska, način života, bioarheologija, populacijska struktura, mobilnost, prehrana, nasilje]]></keywords_hr><keywords_en><![CDATA[prehistory, Croatia, lifestyle, bioarchaeology, population structure, mobility, diet, violence]]></keywords_en><summary_hr><![CDATA[Svrha ovog projekta jest istražiti kompleksan set bioloških, društvenih i kulturnih promjena i procesa koji su se odvijali na području Hrvatske između ranog neolitika i kasnog brončanog doba (6000.-1000. god. pr. Kr.) kroz sveoubuhvatno multi- i interdisciplinarno istraživanje ljudskih bioloških ostataka koje kombinira klasične arheološke i bioarheološke metode s najsuvremenijim tehnikama kao što su analize stabilnih izotopa i drevne DNA, radiološke i geometrijsko-morfometrijske analize, radiokarbonsko datiranje i mikroCT skeniranje. Istraživanjem će biti obuhvaćeno 20 prapovijesnih arheoloških nalazišta iz svih krajeva Hrvatske s 400 kostura (300 kosturnih i 100 paljevinskih ukopa). PASTLIVES projekt će obraditi slijedeća istraživačka pitanja: a) populacijska kretanja, demografija i društvena organizacija; b) populacijska genetika; c) prehrana i opće zdravlje; d) namjerno nasilje i sukobi. Spomenuta pitanja biti će proučavana kroz korištenje dva glavna pristupa: a) regionalni, i b) temporalni, tj. projekt će uvidjeti postoje li regionalne i kronološke razlike u određenim biološkim pokazateljima kao što su prosječna životna dob, očekivani životni vijek, prehrana i opće zdravstveno stanje između proučavanih prapovijesnih populacija. Uz to, dobiveni podaci usporedit će se na temelju spola te dobnih i socijalnih skupina kako bi se provjerilo je li neka od ispitivanih kategorija bitno utjecala na kvalitetu života analiziranih osoba. Kako bi se dobio još bolji uvid u istraživane fenomene rezultati dobiveni ovim istraživanjima usporedit će se sa sličnim podacima iz Mađarske. Predloženi pristup će omogućiti bolje razumijevanje i dobivanje jasnije slike o različitim aspektima prapovijesnog života (i smrti) kao što su populacijska struktura, pogrebne prakse i običaji, pojava nasilja,  prehrana, mobilnost i seobe na području Hrvatske ali i u širem europskom kontekstu. ]]></summary_hr><summary_en><![CDATA[This project will investigate a complex set of biological, social and cultural changes and processes that took place on the territory of the present-day Croatia between the early Neolithic and the late Bronze Age (ca 6000 BCE and 1000 BCE) through a comprehensive multi- and interdisciplinary study of human biological remains using a combination of conventional archaeological and bioarchaeological methods, stable isotopes, radiological and aDNA analyses, radiocarbon dating, microCT scanning, and geometric morphometric analyses. The project will involve 20 Croatian prehistoric sites with over 400 individuals (300 inhumation and 100 cremation burials). PASTLIVES project will address the following research questions: a) population movements, demography and social organization; b) population genetics; c) subsistence and overall health; and d) violence and conflict. These objectives and research questions will be explored by using two main approaches: regional (cross-sectional) and temporal (longitudinal), i.e. the project will establish possible regional and temporal differences between the prehistoric populations in terms of studied parameters such as average age at death, life expectancy, diet, and general health. All observed data will be compared in terms of sex, age and social groups in order to test whether any of these features played a significant role in the quality of life of the analyzed individuals. In order to get a better perspective the data obtained by this study will be compared with contemporaneous bioarchaeological, isotopic and genetic data from Hungary. This approach will enable a better understanding of various aspects of prehistoric life (and death) such as population structure, mortuary practices, violence, diet and mobility on the territory of the present-day Croatia but also in a broader European context.]]></summary_en></project><project>
<id>4065</id><title_hr><![CDATA[Razlaganje električnim poljem u tankim optičkim slojevima - nanostrukturiranje, dopiranje, porozni slojevi]]></title_hr><title_en><![CDATA[Electric field assisted dissolution in thin optical films - nanostructuring, doping, porous layers]]></title_en><user_id>1019</user_id><user_firstLast_name>Vesna Janicki</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-2168</code><acronim><![CDATA[REPTOSNANODOPS]]></acronim><duration>01.09.2017 - 28.02.2022</duration><status>Završio</status><financ_value>124.693,08 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>812, 2656, 2846, 19499, 2916, 25344, 28902, 20097, 25531, 25533, </team_members_id><team_members_names><![CDATA[Jordi Sancho-Parramon, Boris Okorn, Jordi Arbiol, Miodrag Oljaca, Vesna Blažek Bregović, Petar Pervan, TamilSelvi Selvam, Ivana Fabijanić, Du Pasquier Aurelien, Persefoni Kechagia, ]]></team_members_names><keywords_hr><![CDATA[tanki slojevi, dopiranje, razlaganje električnim poljem, Li-ion tankoslojne baterije, porozni slojevi, metalne nanočestice, nanostrukturiranje]]></keywords_hr><keywords_en><![CDATA[thin films, doping, electric field assisted dissolution, Li-ion thin film batteries,  porous layers,  metal nanoparticles, nanostructuring]]></keywords_en><summary_hr><![CDATA[Proces izmjene metalnih iona se koristi već stotinama godina u proizvodnji obojenih stakala. Kao izvor metalnih iona može se koristiti sloj metala u čvrstom stanju. Da bi se ubrzala difuzija primjenjuje se umjereno zagrijavanje i električno polje. Istraživanja su pokazala da u ovakvim uvjetima dolazi do razlaganja metalnih nanočestica (NČ) uronjenih u staklo, dielektrični tanki sloj ili višeslojni sustav. Ovaj proces je poznat kao razlaganje električnim poljem (EFAD - electric field assisted dissolution). Ovaj proces ima nekoliko zanimljivih efekata. Primjenom EFAD-a na NČ uronjene u dielektričnu matricu, u njoj ostaju šupljine - pore. Razlaganjem metalnih NČ primjenom strukturirane elektrode, uzorak s elektrode se preslikava na sistem s metalnim NČ. Zagrijavanjem podloge dopirane metalnim ionima u njoj se formiraju NČ. Nedavno je pokazano da metal ponovno izlazi na površinu zagrijavanjem u atmosferi vodika, formirajući inverzni uzorak onome strukturirane primijenjene elektrode. Navedeno pokazuje brojne mogućnosti EFAD-a: dopiranje, formiranje poroznih slojeva i restrukturiranje. No, unatoč velikom potencijalu EFAD-a, znanstvene aktivnosti koje ga uključuju nisu brojne, te ostaju na nivou baznih istraživanja, s primjenom samo za pripremu nanokompozitnog stakla s Ag NČ. Ovim projektom bi se sistematično istražio EFAD kao metoda dopiranja i izrade poroznih slojeva. Projekt se ne bi ograničio samo na bazna istraživanja. Postignute spoznaje bi se primijenile za poboljšanje karakteristika punjivih litijskih tankoslojnih baterija i izradu nanostruktura reverznim restrukturiranjem. Radi znatnog potencijala EFAD-a, dio vremena i resursa će se posvetiti i ostalim mogućim primjenama.]]></summary_hr><summary_en><![CDATA[The ion exchange process has been used for hundreds of years in production of stained glass windows. A solid metal film can be used as the dopant source. Moderate annealing and electric field are applied to enhance the penetration of dopant ions. Recent research has shown that these conditions enable the dissolution of metal nanoparticles (NP), whether they are embedded in glass, dielectric thin film or multilayer system. This process in known as electric field assisted dissolution (EFAD). It opens many different possibilities. EFAD applied to NP embedded in dielectric matrix results in pores remaining on the positions of NP. If structured electrode is applied to NP containing system, the pattern from the electrode is copied onto the system. By annealing a metal ion doped substrate, metal NP form in the substrate. Very recent research has shown that annealing in hydrogen atmosphere makes metal ions diffuse to the surface, forming pattern inverse to the one of the applied electrode. All of this presents numerous possibilities of EFAD: doping, porous layers formation and restructuring. However, despite of EFAD great potential, scientific activities involving this process remain modest, at the level of a fundamental research and applied only for Ag NP nanocomposite glass preparation. This project will systematically study EFAD as a method for doping of different kinds of substrates and for preparation of porous layers. The project will not be limited merely to fundamental research. The obtained results will be applied to improve characteristics of rechargeable thin film lithium batteries and fabrication of nanostructures by reverse restructuring. Due to the significant potential of EFAD, part of time and resources will be devoted to the other applications as well. ]]></summary_en></project><project>
<id>4071</id><title_hr><![CDATA[Naracije straha: Od starih zapisa do nove usmenosti]]></title_hr><title_en><![CDATA[Narrating Fear: From Archival Records to a New Orality]]></title_en><user_id>7999</user_id><user_firstLast_name>Renata Jambrešić Kirin</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-2463</code><acronim><![CDATA[FEAR]]></acronim><duration>17.03.2017 - 16.09.2021</duration><status>Završio</status><financ_value>75.377,26 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Etnologija i antropologija, </scie_field_hr><scie_field_en>Ethnology and anthropology, </scie_field_en><institution_hr><![CDATA[Institut za etnologiju i folkloristiku]]></institution_hr><institution_en><![CDATA[Institute of Ethnology and Folklore Research in Zagreb]]></institution_en><team_members_id>19149, 19642, 19157, 19147, 608, 19697, 19264, </team_members_id><team_members_names><![CDATA[Jelena Marković, Evelina  Rudan Kapec , Luka  Šešo, Nataša Polgar, Una  Bauer, Natka Badurina, Suzana Marjanić, ]]></team_members_names><keywords_hr><![CDATA[folkloristika, naracija, strah, performativnost, usmenost, usmena tradicija, sekundarna usmenost, nova usmenost, digitalni folklor]]></keywords_hr><keywords_en><![CDATA[folklore research, narration, fear, performativity, orality, oral tradition, secondary orality, new orality, weblore]]></keywords_en><summary_hr><![CDATA[Cilj projekta Naracije straha: od starih zapisa do nove usmenosti (FEAR) jest istražiti kako se pripovjednim strategijama i propovijed(a)nim događajima strahovi oblikuju, potiču, usmjeruju i rastaču u svakodnevnoj izravnoj komunikaciji, ali i u javnome diskursu, u medijima i na društvenim mrežama, u književnosti, vizualnim i izvedbenim umjetnostima i dr. Nadovezujući se na tradiciju istraživanja koja su Institut za etnologiju i folkloristiku upisala na kartu svjetske folkloristike, istraživački tim na projektu Naracije straha kani objediniti recentne spoznaje folklorističkih, književnoteorijskih, kulturnoantropoloških, feminističkih, psihoanalitičkih i drugih pristupa strahu u narativnim tekstovima različite provenijencije: usmeni, pisani, stari folkloristički zapisi, noviji etnografski zapisi, sudski zapisnici, logoraška svjedočenja, naracije mrežno oblikovanih “zajednica sjećanja” i “paranoičnih skupina”. Cilj projekta je pokazati prožimanje kodova pisane i usmene, medijske i mrežne „narativne kulture“, izdvojiti elemente pripovjedne artikulacije i autorefleksije govornika obuzetog strahom, kao i uočiti snagu magijskog potencijala jezika da govornika suoči sa strahom (tzv. ritualno „istjerivanje straha“), ali i terapeutskog potencijala priče (npr. narativna terapija, priče o traumi). Brojnim terenskim istraživanjima, interaktivnim mrežnim Arhivom straha i teorijskim promišljanjima fenomena koji se – uz nadu i poniženje - smatra ključnim za razumijevanje novih geopolitičkih i kulturnih podjela zemalja svijeta, suradnici na projektu će pridonijeti boljem poznavanju političkog i afektivnog, grupnog i individualnog, društvenog i virtualnog ponašanja ljudi u čijem su temelju (mahom nesvjesni) strahovi, porivi i vjerovanja. Namjera mu je afirmirati folkloristiku kao humanistički utemeljenu, inovativnu i refleksivnu disciplinu koja svaki fenomen verbalnog folklora promatra u njegovoj cjelini – od individualne varijacije do kulturne specifičnosti.]]></summary_hr><summary_en><![CDATA[The aim of the project Narrating Fear: From Archival Records to a New Orality (FEAR) is to research the ways in which narrative strategies and narrated/narrative events help to shape, instill, direct and resolve fears in everyday direct communication, but also in public discourse, on social networks,  media, literature, visual and performing arts, and others. Continuing the tradition of research that has put the IEF on the map of world folkloristics, FEAR’s research team intends to bring together the recent knowledge of folklore research, literary theory, cultural anthropology, feminism, psychoanalysis, and other approaches to fear in narrative texts of various provenances: oral, written, old folkloristic and newer ethnographic writings, court records, camp witness testimonies, and narrations of the network of “community of memories” and “paranoid groups”. The project aims to show the interpenetration of the codes of written and oral, medial and network “narrative culture”, to outline the elements of narrative articulation and self-reflexion of fear-stricken speaker, as well as noting the power of language’s magical potential to make the speaker face their fear (so-called ritualistic “fear exorcising”), but also the story’s therapeutic potential (e.g. narrative therapy). Through numerous field researches, interactive Fear Archive and theoretical reflections of the phenomenon that is – along with hope and humility – considered crucial to understanding the new geopolitical and cultural divisions of countries, our collaborators will contribute to a better cognition of the political and affective, group and individual, social and virtual human behavior, which serves as basis for fears, drives and beliefs. The intention of FEAR is to affirm folkloristics as an innovative, reflexive, and humanistic discipline, which observes every phenomenon of verbal folklore as a whole – from individual variation to cultural specificity.]]></summary_en></project><project>
<id>4072</id><title_hr><![CDATA[Antun Jančić i fortifikacijska arhitektura Mletačke Republike]]></title_hr><title_en><![CDATA[Antun Jančić and Fortification Architecture of the Venetian Republic]]></title_en><user_id>2693</user_id><user_firstLast_name>Andrej Žmegač</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-5776</code><acronim><![CDATA[JANCIC]]></acronim><duration>01.03.2017 - 29.02.2020</duration><status>Završio</status><financ_value>24.075,92 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Povijest umjetnosti, Povijest, </scie_field_hr><scie_field_en>Art history, History, </scie_field_en><institution_hr><![CDATA[Institut za povijest umjetnosti]]></institution_hr><institution_en><![CDATA[Institute of Art History, Zagreb]]></institution_en><team_members_id>17219, 1397, </team_members_id><team_members_names><![CDATA[Elisabetta Molteni, Darka Bilić, ]]></team_members_names><keywords_hr><![CDATA[utvrde, arhitektura, Antun Jančić, Mletačka Republika, Dalmacija, Johann Matthias von der Schulenburg]]></keywords_hr><keywords_en><![CDATA[fortifications, architecture, Antun Jančić, Venetian Republic, Dalmatia, Johann Matthias von der Schulenburg]]></keywords_en><summary_hr><![CDATA[U središtu projekta stoji djelo Antuna Jančića, po svemu sudeći važnoga vojnog arhitekta Mletačke Republike. Prvi je cilj projekta utvrditi glavne biografske činjenice, lokacije i opseg njegovih aktivnosti te procijeniti njegovo djelo. Hipoteza je projekta da je Jančić bio najvažniji graditelj utvrda s hrvatske strane Jadrana. Metodološki, tumačit će ga se u kontekstu ostalih mletačkih graditelja te institucija i procedura pri gradnji utvrda. Živio je u kasno doba Mletačke Republike te će ovaj projekt preko teme Jančića svjesno afirmirati pojam „kasnih mletačkih utvrda“. Rezultati projekta bit će izlaganja na konferencijama, znanstveni radovi te međunarodni skup u Hrvatskoj o kasnim mletačkim utvrdama. Ne manje važna bit će usporedna popularizacija teme.]]></summary_hr><summary_en><![CDATA[The focus of the project is the work of Antun Jančić, apparently an important military architect of the Venetian Republic. The first objective of the project is to identify the main biographical facts, the locations and the scope of his activities and to evaluate his work. The hypothesis of the project is that Jančić was the most important fortification architect coming from the eastern side of the Adriatic. As the methodology is concerned, he will be interpreted in the context of other Venetian architects, institutions and procedures in the construction of fortifications. He has lived in the late period of the Venetian Republic, so this project will through the topic of Jančić consciously be devoted to the concept of &#39;&#39;late Venetian fortresses&#39;&#39;. Results of the project will be participating at conferences, an international conference in Croatia on late Venetian fortifications and research papers. No less important will be a parallel popularization of the subject.]]></summary_en></project><project>
<id>4073</id><title_hr><![CDATA[Glazbeni izvori Dalmacije u kontekstu srednjoeuropske i mediteranske glazbene kulture od 18. do 20. stoljeća]]></title_hr><title_en><![CDATA[Musical sources of Dalmatia in the context of the Central European and Mediterranean musical culture from the 18th to the 20th century]]></title_en><user_id>11264</user_id><user_firstLast_name>Ivana Tomić Ferić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-2061</code><acronim><![CDATA[GIDAL]]></acronim><duration>01.03.2017 - 28.02.2021</duration><status>Završio</status><financ_value>75.173,00 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Znanost o umjetnosti, Povijest, Etnologija i antropologija, </scie_field_hr><scie_field_en>Arts, History, Ethnology and anthropology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu]]></institution_hr><institution_en><![CDATA[University of Split]]></institution_en><team_members_id>17763, 19257, 19759, 19208, 24402, </team_members_id><team_members_names><![CDATA[Maja Milošević, katica burić ćenan, Vilena Vrbanić, Jelica  Valjalo Kaporelo , Paula Jurišić, ]]></team_members_names><keywords_hr><![CDATA[glazbeni arhivi, glazbene zbirke, muzikalije, glazbeni život, glazbena baština, Split, Hvar, Zadar, Dubrovnik, Hrvatska, Europa]]></keywords_hr><keywords_en><![CDATA[music archives, music collections, music manuscripts and prints, musical life, musical heritage, Split, Hvar, Zadar, Dubrovnik, Croatia, Europa]]></keywords_en><summary_hr><![CDATA[Slojevitost glazbene kulture šireg dalmatinskoga područja odraz je višestoljetno njegovanog i širokim utjecajima prožetog pučkog, crkvenog i umjetničkog muziciranja. Kako bi se ta slojevitost jasno identificirala, potrebno je  prikupiti i interpretirati materijalnu glazbenu baštinu, pohranjenu u crkvenim, samostanskim, privatnim ili pak arhivima kulturnih institucija diljem obale. U početnim se fazama projekta predviđa rad na sređivanju, digitalizaciji i katalogizaciji glazbenih zbirki (u Splitu, Hvaru, Zadru, Dubrovniku), a potom na njihovoj analizi, kontekstualizaciji i interpretaciji kako bi se omogućila (re)konstrukcija (povijesti) glazbene kulture i određivanje njezine uloge u stvaranju lokalnog, regionalnog, nacionalnog i transnacionalnog kulturnog identiteta. Ciljevi projekta: obrada (transkripcija, prijevod) korespondencije J. Bajamontija; tiskano izdanje tematskog kataloga djela J. Raffaellija; digitalizacija rukopisnih muzikalija A. Novaka; kataloška obrada  zbirke muzikalija u Arhivu Dominikanskoga samostana u Starome Gradu; rekonstrukcija djelovanja i repertoara zadarskog opernog kazališta (Teatro Verdi); analiza opusa manje poznatih domaćih i stranih glazbenika koji su djelovali u Dubrovniku od 18. do 20. stoljeća (T. Resti, G. Valenti, A. Frezza, G. Kraglich, G. Zabolio); kontekstualizacija glazbenog života Dalmacije u okvirima odgovarajućih europskih strujanja.Važnost predloženog projekta ogleda se u otkriću novih spoznaja o hrvatskoj glazbenoj baštini ali i onoj europskoj sačuvanoj u Hrvatskoj, koje će poslužiti kao čvrsta referenca praktičnim glazbenicima i budućim istraživačima povijesti umjetničke (crkvene i svjetovne) glazbe. Tijek ostvarenih rezultata bit će popraćen objavom niza članka, većih studija i monografija te uključivanjem dobivenih podataka u međunarodne banke podataka i u domaći i inozemni izvoditeljski repertoar pojedinih dosada nepoznatih i nedostupnih vrijednih djela hrvatskih autora 18., 19. i 20 stoljeća.]]></summary_hr><summary_en><![CDATA[The multi-layered musical culture of the wider Dalmatian area is the reflection of the folk, sacred and artistic music making inherited for the centuries. In order to clearly identify these layers it is necessary to collect and to interpret the material musical heritage, stored in churches, monasteries, private archives and cultural institutions along the Adriatic coast. The work on arranging, digitalisation and cataloguing of music collections (at Split, Hvar, Zadar, Dubrovnik) is predicted for the initial stages of the project, followed by their analysis, contextualization and interpretation to allow (re)construction of the history of musical culture and determination of its role in the creation of local, regional, national and trans-national cultural identity.Scientific objectives of the project: elaboration of the correspondence of  J. Bajamonti;  thematic catalogue of works of J. Raffaelli; digitalisation of music manuscripts of A. Novak; cataloguing of music manuscripts and prints from the Archives of the Dominican monastery at Stari Grad; reconstruction of the activities and repertoire of the Zadar opera theatre (Teatro Verdi); work analysis of less known domestic and foreign musicians in Dubrovnik from 18th to the 20th century; contextualization of the Dalmatia musical life in the frame of the relevant European currents. Proposed project importance reveals through the discovery of new facts about not only Croatian musical heritage but also the European one preserved in Croatia, facts which will serve as a strong reference to practical musicians and all future researchers of the history of art music. The course of the achieved results will be disclosed by publication of articles, studies and monographs as well as the inclusion of obtained data to the international bank of music data (R.I.S.M.) likewise in domestic and foreign performing repertoire of some so far unknown and inaccessible valuable works of Croatian authors of the 18th, 19th and 20th century.]]></summary_en></project><project>
<id>4075</id><title_hr><![CDATA[Visokoenergijska astronomija gama-zraka teleskopima MAGIC i CTA]]></title_hr><title_en><![CDATA[ Very high energy gamma-ray astronomy with the MAGIC and CTA telescopes]]></title_en><user_id>6374</user_id><user_firstLast_name>Nikola Godinović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-9782</code><acronim><![CDATA[MAGIC-CTA]]></acronim><duration>17.07.2017 - 16.06.2022</duration><status>Završio</status><financ_value>76.713,78 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Fakultet elektrotehnike, strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Electrical Engineering, Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>4599, 6750, 5738, 19354, 55, 19301, 3652, 19423, 3127, 19815, 24438, 25265, 25065, </team_members_id><team_members_names><![CDATA[Iva  Šnidarić, Damir Lelas, Željka Marija  Bošnjak, Darko Zarić, Tihomir Surić, Tomislav Terzić, Ana Babić, Dijana Dominis Prester, Dario Hrupec, Saša Mićanović, Stefan Cikota, Lovro Pavletić, Marina Manganaro, ]]></team_members_names><keywords_hr><![CDATA[gama-zrake,  MAGIC, CTA, pulsari, aktivne galaktičke jezgre]]></keywords_hr><keywords_en><![CDATA[gamma rays, MAGIC, CTA, pulsars, active galactic nucleai]]></keywords_en><summary_hr><![CDATA[Visokoenergijska astronomija (VHE) gama-zraka izučava najsilovitije procese u svemiru. Ciljevi ovog projektnog prijedloga su izučavanje emisije VHE gama-zraka iz aktivnih galaktičkih jezgri (AGN), pulsara i proširenih izvora pomoću postojećih teleskopa MAGIC, zatim doprinos dizajnu, izgradnji i puštanju u rad teleskopskog niza Cherenkov Telescope Array (CTA), te analizi prvih podataka prikupljenih tim teleskopima. Analiza VHE gama-zraka iz pulsara omogućit će izučavanje akceleracijskih mehanizmima u magnetosferi neutronskih zvijezda. Za bolje razumijevanje emisijskih mehanizama VHE gama-zraka iz AGN provodit će se opažanja i analizirati korelacije između zračenja u različitim područjima elektromagnetskog spektra. Iako su izvori VHE gama-zraka većinom točkasti, znatan broj ima konačnu kutnu veličinu, za što ne postoji standardizirana analiza podataka. Kako bi se u potpunosti iskoristio potencijal teleskopa MAGIC, a pogotovo budućih teleskopa CTA čije će performance biti za red veličine bolje, razvit ćemo metodu analize proširenih izvora. To će omogućiti izučavanje morfologije izvora VHE gama-zraka, te detekciju drugih izvora opažanih u istom vidnom polju. Monte Carlo simulacijama optimizirat ćemo raspored teleskopa CTA te konfiguracija okidača, za koji će sustav biti najosjetljiviji. Da se dostignu zahtjevane performance Large Size Telescope (LST) (najveći teleskopi u nizu CTA, zrcalo promjera 23 m), nužno je poznavati položaj optičke osi teleskopa u odnosu na centar kamere s preciznošću od 5 lučnih sekundi. Dizajnirati ćemo, testirati, izgraditi i upogoniti sustav za praćenje položaja optičke osi LST teleskopa. Kako na opažani spektar  izvora gama-zraka  Čerenkovljevim teleskopima, utječe  atmosferska transmisija, razvit ćemo novu metodu raspodjele opažačkog vremena koju ćemo testirati na MAGIC teleskopima, a kasnije nadograditi i prilagoditi za potrebe CTA. Razvit ćemo i softverski alat za dugoročno praćenje performansi CTA teleskopa.]]></summary_hr><summary_en><![CDATA[Very high energy (VHE) gamma-ray astronomy studies the most violent processes in the Universe. Aims of this project proposal are study of VHE gamma-ray emission from active galactic nuclei (AGN), pulsars and extended sources using MAGIC telescopes, as well as participation in the design, construction and commissioning of the future Cherenkov Telescope Array (CTA) and analysis of the first data collected with these telescopes. Analysis of VHE gamma-rays from pulsars will enable study of the particle acceleration mechanism in pulsar magnetospheres. A better understanding of the VHE gamma-ray emission mechanisms in AGN will be achieved through observations and correlation analysis of data in different parts of the electromagnetic spectrum. Although mostly point-like, a significant number of VHE sources has a finite angular size, and are not covered by the standard data analysis. In order to fully exploit the potential of the MAGIC telescopes, and in particular the future CTA with even an order of magnitude higher performance, we will develop a method for extended sources data analysis. This will enable study of the morphology of VHE gamma-ray sources, and analysis of other sources observed in the same field of view. Monte Carlo studies will be used to optimize the CTA performance. To achieve the targeted performances of the Large Size Telescope (LST) of CTA, it is necessary to know the position of the telescope optical axis in respect to the centre of the camera with precession of 5 arc seconds. We will design, build and commission the position of the telescope optical axis monitoring system with the required precision. Since the gamma-ray spectra observed by Cherenkov telescopes depend on the atmospheric transmission, an improved observation scheduling method will be developed and implemented first in the MAGIC observation program, and later in the CTA. The software tool for long-term monitoring of the CTA telescope performances will be developed.]]></summary_en></project><project>
<id>4077</id><title_hr><![CDATA[Genetički i epigenetički biomarkeri urođene imunosti u KOPB-u i karcinomu pluća]]></title_hr><title_en><![CDATA[Genetic and epigenetic biomarkers of innate immunity in COPD and lung cancer]]></title_en><user_id>13083</user_id><user_firstLast_name>Jelena Knežević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-1441</code><acronim><![CDATA[LungInflaCare]]></acronim><duration>25.05.2017 - 24.04.2022</duration><status>Završio</status><financ_value>131.793,75 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>3319, 5777, 3422, 3452, 5915, 27625, 27624, 27627, </team_members_id><team_members_names><![CDATA[Nada Oršolić, Gordana Bubanović, Marko Jakopovic, Miroslav Samarzija, Sven Seiwerth, Maja Šutić, Jurica Baranašić, Matea Kurtović, ]]></team_members_names><keywords_hr><![CDATA[KOPB, tumori pluća, urođena imunost, receptori, genetika, epigenetika, biomarkeri]]></keywords_hr><keywords_en><![CDATA[COPD, lung cancer, innate immunity, receptors, genetic, epigenetic, biomarkers]]></keywords_en><summary_hr><![CDATA[Kronična opstruktivna plućna bolest (KOPB) i tumori pluća vodeći su uzroci smrtnosti u svijetu. Usko su povezani i dijele zajedničke faktore rizika, pušenje i genetičku predispoziciju. Naime, samo 20% pušača razvije KOPB ili tumor pluća, dok prisutnost KOPB-a, definiranog smanjenim ekspiratornim volumenom zraka u 1 sekundi (FEV1), povećava rizik nastanka tumora pluća za 4 do 5 puta. Mehanistička povezanost KOPB-a i tumora pluća još uvijek je nedovoljno poznato, vjerojatno zbog heterogene kliničke slike obje bolesti.Urođeni imunološki odgovor neophodan je za održavanje zdravlja pluća i tkivne homeostaze, no nekontrolirana upala povezuje se s nastankom KOPB-a i tumora pluća. Stanice dišnog epitela i imunosne stanice eksprimiraju različite receptore za specifično prepoznavanje određenih uzoraka (eng. pattern recognition receptors, PPR) koji su sudjeluju u reakciji urođenog imunološkog odgovora na patogene i molekule koje mogu oštetiti tkivo. Poznato je da je dugotrajna i opsežna upala dovoljan rizični faktor za nastanak KOPB-a i karcinoma pluća. Međutim, još uvijek je potpuno nepoznato kako je genetička raznolikost receptora urođene imunosti povezana s regulacijom upale u plućima i dišnim putevima i kako ti procesi doprinose razvoju KOPB-a i nastanku tumora na molekularnoj i staničnoj razini. Također, histološka i molekularna heterogenost tumora pluća samog po sebi, otežava naše razumjevanje karcinogeneze i liječenja obje bolesti. Obzirom na veliku učestalost i snažnu povezanost KOPB-a i tumora pluća i nepostojanje adekvatne terapije za obje bolesti, identifikacija specifičnih genetičkih varijanti i rasvjetljavanje njihove uloge u bolesnim stanjima pridonijeti će liječenju bolesti na osobnom nivou. Stoga su specifični ciljevi predloženog projekta sažeti u dva radna područja:1. Identifikacija genetičkih i epigenetičkih faktora rizika zajedničkih KOPB-u i tumorima pluća2. Utvrđivanje mehanističke poveznice KOPB-a i TP-a uzimajući u obzir ulogu receptora urođene imunosti]]></summary_hr><summary_en><![CDATA[Chronic obstructive pulmonary disease (COPD) and lung cancer (LC) are leading causes of morbidity and mortality worldwide. They are closely related and share cigarette smoke as a common environmental risk factor. Genetic predisposition is also shared; only minority of smokers (20%) develops LC or COPD. The presence of COPD, defined as reduced forced expiratory volume in 1 second (FEV1), increases the risk to development of LC up to 4,5 fold. The mechanistic explanation of this finding is still poorly understood, likely due to heterogeneous nature of diseases. Innate immune response is essential for maintaining lung health and tissue homeostasis but unbalanced inflammation of lungs is associated with diseased conditions, such as COPD and LC. Pulmonary epithelial and immune cells are equipped with pattern recognition receptors (PRRs) able to initiate appropriate innate immune response to invading pathogens or tissue damage associated molecules. It is well known that excessive inflammation is sufficient to confer risk to both diseases. There is still lack of knowledge how genetic variability of innate immunity receptors orchestrate inflammation in lungs and how these processes contribute to development of both diseases, on molecular and cellular level. Also, the histological and molecular heterogeneity of LC, by itself, makes our understanding of carcinogenesis, as well as treatment of disease challenging. Because of global increase in COPD and LC prevalence, strong association of COPD with lung cancer and absence of specific therapeutic targets for both disease, identification of specific gene variants and their involvement in diseased conditions will improve disease treatment at personalized level. The specific aims of this project could be summarized in two work areas:1. Identification of shared genetic and epigenetic risk factors/biomarkers for COPD and LC2. Determination of common mechanistic link of COPD and LC considering the role of innate immunity receptors]]></summary_en></project><project>
<id>4079</id><title_hr><![CDATA[Kvantno-kemijski dizajn, priprava i biološka svojstva organometalnih derivata nukleobaza]]></title_hr><title_en><![CDATA[Quantum chemical design, synthesis and biological properties of organometallic nucleobase derivatives]]></title_en><user_id>5594</user_id><user_firstLast_name>Valerije Vrček</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-1137</code><acronim><![CDATA[OrDeN]]></acronim><duration>01.03.2017 - 28.02.2021</duration><status>Završio</status><financ_value>124.361,27 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, Biologija, </scie_field_hr><scie_field_en>Chemistry, Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Farmaceutsko-biokemijski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Pharmacy and Biochemistry]]></institution_en><team_members_id>4994, 2509, 2512, 1390, 355, 25235, </team_members_id><team_members_names><![CDATA[Davor Šakić, Senka Djaković, Jasmina Lapić, Ana Marija Marjanović, Srećko Kirin, Mateja Toma, ]]></team_members_names><keywords_hr><![CDATA[metalocen, nukleozid, bioaktivnost, elektrokemija, DFT računi]]></keywords_hr><keywords_en><![CDATA[metallocene, nucleoside, bioactivity, electrochemistry, DFT calculations]]></keywords_en><summary_hr><![CDATA[Organometalni derivati nukleobaza (OrDeN-i) nova su generacija konjugata u kojima su povezani metaloceni s temeljnim supstrukturnim elementima nasljeđivanja. Zbog elektrofornih i bioaktivnih svojstava OrDeN-i nalaze primjenu u (bio)analitičkoj i medicinskoj kemiji. Priprava OrDeN-a se temelji na sintetskoj kopulaciji organometalnog dijela i heterocikličke baze koristeći razne vrste mostova. Izbor fragmenata uglavnom je vođen pristupom što veće raznolikosti strukturnih motiva. U okviru ovog projekta strukturne modifikacije OrDeN-a bit će usmjerene prema pripravi derivata s izraženim elektrokemijskim i biološkim svojstvima. Eksperimentalnom dijelu istraživanja prethodit će opsežni kvantno-kemijski izračuni. Metodama teorije funkcionala gustoće (DFT metode) moguće je predvidjeti kemijska svojstva OrDeN-a, poput reaktivnosti/stabilnosti, redukcijskog potencijala, supstitucijskih i solvatacijskih efekata. Ti parametri mogu poslužiti za dizajn OrDeN-a s poboljšanim biološkim svojstvima. Koristit će se one DFT metode koje se tijekom sustavne procjene teorijskih modela (benchmarking) pokažu optimalnim u opisu bioorganometalnih modela za koje postoje eksperimentalni podaci. Novi strukturni elementi OrDeN-a uključuju funkcionalni most, niz homoanularnih supstituenata, odabrane parove metalocena  i nukleobaza, te bis-adukte. Novi most (linker) koji povezuje dva osnovna dijela OrDeN-a je karbonilna skupina i njezini reducirani oblici, hidroksilna i metilenska skupina. Elektronska komunikacija metalocena i nukleobaze ovisit će, dakle, o oksidacijskom stanju i hibridizaciji funkcionalnog mosta, a podešavat će se uvođenjem odabranih supstituenata na ciklopentadienilni prsten. Usporedba kvantno-kemijskih procjena s elektrokemijskim/ biološkim profilima pripravljenih modela upotrijebit će se u (re)dizajnu parova metalocena i nukleobaza, te ciljanih bis-adukata OrDeN-a.]]></summary_hr><summary_en><![CDATA[Organometallic nucleobase derivatives (OrDeNs) correspond to a new generation of conjugates in which metallocenes are linked to the basic structural elements of heredity. Due to their electrophoric and bioactive properties, OrDeNs are of use in (bio)analytical and medicinal chemistry. The preparation of OrDeNs is based on the copulation reaction between the organometallic part with a heterocyclic base, by using different linkers. The choice of fragments usually follows the target of the ever-growing diversity of structural motifs. In this project all modifications of OrDeNs structures will be directed toward derivatives with marked electrochemical and biological properties. An extensive quantum chemical study will precede the experimental part of the research. By using the density functional theory methods (DFT methods) the chemical properties of OrDeNs, such as stability/reactivity, reduction potential, substituent and solvation effects, can be predicted. These parameters can assist in designing OrDeNs with enhanced bioactivity. A benchmark study in evaluating DFT methods will be performed. DFT methods which are superior in the description of biorganometallic models (for which experimental data are known) will be used to study OrDeNs. New structural elements in OrDeNs include the functional linker, a series of homoannular substituents, selected metallocene-nucleobase pairs, and bis-adducts. A new linker type, which connects the two constitutional parts in OrDeNs, is a carbonyl group and its reduced forms, hydroxyl and methylene groups. The electron communication between metallocene and nucleobase depends, therefore, on the oxidation state and hybridization of the functional linker, and can be tuned by using selected substituents at the cyclopentadienyl ring. The interplay between quantum chemical estimates and electrochemical/biological profiles for model compounds will advance the (re)design of new metallocenes-nucleobase pairs and bis-adducts of OrDeNs.]]></summary_en></project><project>
<id>4081</id><title_hr><![CDATA[MATH-BTB proteini kao regulatori transkripcije i RNA posredovane metilacije DNA u biljnom razvitku]]></title_hr><title_en><![CDATA[MATH-BTB proteins as switches between transcription and RNA-directed DNA methylation during plant development ]]></title_en><user_id>3746</user_id><user_firstLast_name>Dunja Leljak-Levanić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-6229</code><acronim><![CDATA[PHYTOMETHDEV]]></acronim><duration>01.03.2017 - 31.12.2021</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>4217, 791, 3735, 5012, 19214, 3121, 5596, 19376, 6193, 24301, 25338, 28653, 28868, 25017, 25016, </team_members_id><team_members_names><![CDATA[NATAŠA BAUER, Branka Salopek Sondi, Nenad Malenica, Snježana Mihaljević, Željka Vidaković-Cifrek, Dubravko Pavoković, Vedrana Vičić Bočkor, Kristina Majsec, Lidija Begović, Lucija Markulin, Tamara Vuk, Mirta Tokić, Sandra Vitko, Andreja Škiljaica, Mateja Jagić, ]]></team_members_names><keywords_hr><![CDATA[metilacija DNA, RdDM, MATH-BTB, embriogeneza, stres, biljke]]></keywords_hr><keywords_en><![CDATA[DNA methylation, RdDM, MATH-BTB, embryogenesis, stress, plants]]></keywords_en><summary_hr><![CDATA[Metilacija DNA jedan je od nekoliko epigenetičkih mehanizama kontrole ekspresije gena. U biljaka raznolikost epigenetičkih mehanizama ima, osim u regulaciji razvojnih procesa, važnu ulogu u fenotipskoj i fiziološkoj prilagodljivosti, te sposobnosti biljaka da prežive i razmnožavaju se u promjenjivom okolišu. Metilacija biljne DNA odvija se na sljedovima CG, CHG i asimetričnom CHH (H simbol za A, C ili T), a svaki od njih ima različite &#39;&#39;genetičke zahtjeve&#39;&#39; za očuvanje. Nesimetrična metilacija CHH ne može se održati i zahtijeva de novo metilaciju u svakom staničnom ciklusu. Proces kojim se to ostvaruje je metilacija DNA usmjerena s RNA (RdDM). Dvije RNA polimeraze specifične za biljke, Pol IV i Pol V sintetiziraju male interferirajuće RNA, odnosno dugačke nekodirajuće molekule RNA, važne za RNA-DNA prepoznavanje. Kompleks DDR predstavlja proteinski kompleks za koji se smatra da je odgovoran za dovođenje enzima Pol V na mjesto regulacije gena, no mehanizam specifičnosti nije jasan. Naši preliminarni rezultati ukazuju da proteini MATH-BTB iz uročnjaka stupaju u interakciju s kompleksom DDR, te tako mogu posredovati u pozicioniranju sustava RdDM. Najnovija otkrića ukazuju da su supstrati proteina BPM transkripcijski faktori. Proteini s ovakvim interakcijskim mogućnostima imaju potencijal  održavanja ravnoteže između metilacije (posredovane Pol V) i transkripcije (posredovane Pol II). Glavni cilj projekta je rasvjetljavanje funkcionalne uloge proteina BPM u regulaciji transkripcije i RdDM-a kao i moguće uloge u biljnoj embriogenezi i prilagodbi na stresne uvjete. Posebna pozornost biti će dana identifikaciji gena čija je transkripcija ili RdDM metilacija uravnotežena proteinom BPM1 (kromatinska imunoprecipitacija-ChIP, ChIP-sekvenciranje). Nadalje, metilacijski uzorak (bisulfitno sekvenciranje) odabranih gena će biti povezan s njihovom ekspresijom (Q-PCR), te s embriogenezom i odgovorom biljaka na stres u linijama s promijenjenim sustavom RdDM ili ekspresijom gena BPM.]]></summary_hr><summary_en><![CDATA[DNA methylation is one of several epigenetic mechanisms used by cells to control gene expression. In plants epigenetic diversity, besides regulating development, presumably contributes in plant phenotypic and physiological plasticity and the ability to survive and reproduce in unpredictable environments. Plant DNA methylation occurs at CG, CHG and nonsymmetrical CHH (where H is A, C or T) sequences, each of which has different genetic requirements for its preservation. Nonsymmetrical CHH methylation cannot be sustained by the maintenance machinery and require de novo methylation in each cell cycle through a process called RNA-directed DNA methylation (RdDM). Two plant specific RNA polymerases, Pol IV and Pol V, produce small interfering RNAs and long non-coding RNAs respectively, which are important for RNA-DNA target sequence recognition. The DDR complex represents a major determinant that is proposed to be responsible for recruitment of the Pol V enzyme to the specific loci, but the mechanism is still not clear. Our preliminary results indicate that Arabidopsis MATH-BTB proteins recognize and interact with the DDR complex and thus might mediate the positioning of RdDM machinery. Recent findings indicate that substrates of BPM proteins are predominantly transcription factors. These two properties of a single BPM protein suggest its capacity to act as a control switch between methylation (mediated by Pol V) and transcription (mediated by Pol II). The main goal of this project is to elucidate the functional roles of BPMs in orchestrating transcription and RdDM, and its possible role in plant embryogenesis and stress adaptation. Particular focus will be placed to identification of genes whose transcription or RdDM methylation is affected by BPMs (by ChIP and ChIP seq). Further, methylation context (bisulfite sequencing) of selected genes will be correlated with their expression (Q-PCR) and with embryogeneis and stress responses in different RdDM and BPM mutant lines.]]></summary_en></project><project>
<id>4084</id><title_hr><![CDATA[Karakterizacija kandidat gena za kongenitalne anomalije bubrega i urotrakta (CAKUT) tijekom razvoja u miša i čovjeka]]></title_hr><title_en><![CDATA[Characterization of Congenital Anomalies of the Kidney and the Urinary tract (CAKUT) candidate genes during mouse and human development]]></title_en><user_id>12479</user_id><user_firstLast_name>Katarina Vukojević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-2575</code><acronim><![CDATA[CAKUT]]></acronim><duration>01.02.2018 - 28.02.2023</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Split School of Medicine]]></institution_en><team_members_id>4338, 19247, 19253, 11243, 19276, 19308, 13069, 19279, 19332, 19378, 4839, 12795, 19571, 19588, 25216, 28630, 25196, 856258, 1192, 26019, 4348, 26117, 865336, 865521, 865520, 26134, </team_members_id><team_members_names><![CDATA[Sandra Kostić, Snježana Mardešić, Fila Raguž, Sandra  Zekić Tomaš, Nenad Kunac, Mirna Saraga-Babić, Ivana Restović, Violeta Šoljić, Boris Kablar, Simone Sanna-Cherchi, Merica Glavina Durdov, Marijan Saraga, Joško Petričević, Vlatka Martinović, Anita Muić, Mirela Lozić Lozić, Ejazul  Haque, Nela Kelam, Ivana  Bočina, Marija Jurić, Natalija Filipović, Ivona Kosović, Mirjana Polović, Vlatka Paštar Paštar, Martina Vukoja, Ivana Šolić Šolić, ]]></team_members_names><keywords_hr><![CDATA[kongenitalne anomalije bubrega i urotrakta, genetika, imunohistokemija, imunofluorescencija, knock-out miš]]></keywords_hr><keywords_en><![CDATA[congenital anomalies of the kidney and urinary tract, genetics, immunohistochemistry, immunofluorescence, knock-out mice]]></keywords_en><summary_hr><![CDATA[Kongenitalne anomalije bubrega i mokraćnog sustava (CAKUT) u 40-50% pedijatrijskih bolesnika dovode do krajnjeg stadija zatajenja bubrega. Među kategorijama CAKUTa, kongenitalna opstruktivna uropatija predstavlja zajednički i teški oblik malformacija. Zbog nedostatka temeljnog uvida o njegovoj primarnoj patogenezi, dijagnostičke i terapijske mogućnosti su ograničene.Nedavno smo identificirali dominantne štetne mutacije u DSTYK genu koji kodira dvostruku serin-treonin i tirozin protein-kinazu, kod osoba s malformacijama mokraćnog sustava koristeći sekvenciranje exoma u kombinaciji s funkcionalnim modelom u zebraste ribice (New Engl J Med 2013). Protein kodiran DSTYK genom djeluje kao pozitivan regulator u signalizaciji faktora rasta fibroblasta (FGF), tijekom nefrogeneze. Osim toga, identificirali smo pet novih gena kandidata za CAKUT koji su pokazali ekspresiju u miša i čovjeka tijekom razvoja urinarnog trakta. Među tim genima, DLG1 i KIF12 su vjerojatno susceptibilni geni za razvoj CAKUTa kod ljudi (Kidney Int 2015).Ovdje predlažemo početnu karakterizaciju funkcije novih gena kandidata za CAKUT tijekom embrionalnog razvoja, nefrogeneze i razvoja uretera. Prvo ćemo istraživati profil vremenskog-prostornog izražaja i ko-lokaliziranje kandidat gena za CAKUT u različitim fazama embriogeneze u tkivima normalnih miševa i ljudskog zametka te bubrega i mokraćnog sustava u razvoju i usporediti markere nefrogeneze i razvoja uretera. Zatim ćemo odabrati jedan visoko prioritetni novi kandidat gen te generirati i okarakterizirati miša koji nosi mutaciju u ovom genu od interesa (knockout miš), zatim ćemo identificirati mehanizme kojima mutacije u ovom genu dovode do malformacija urinarnog trakta kod ljudi.Ova studija je osmišljena kako bi se okarakterizirali funkcionalni učinci kandidat gena za CAKUT u razvoju mokraćnih puteva, identificirati disregulacijske putove i na kraju osmisliti nove dijagnostičke alate i terapijske strategije za taj učestali oblik zatajenja bubrega.]]></summary_hr><summary_en><![CDATA[Congenital Anomalies of the Kidney and the Urinary Tract (CAKUT) account for 40-50% of pediatric end-stage kidney failure. Among CAKUT categories, congenital obstructive uropathy represents a common and severe form. Due to paucity of fundamental insight about its primary pathogenesis, diagnostic and therapeutic options are severely limited.  We recently identified dominant deleterious mutations in DSTYK, encoding a dual serine-threonine and tyrosine protein-kinase, in individuals with urinary tract malformations using exome sequencing combined to functional modeling in zebrafish (New Engl J Med 2013). The protein encoded by DSTYK acts as a positive regulator of fibroblast growth factor (FGF) signaling during nephrogenesis. Additionally, we identified five novel candidate genes for CAKUT that showed specific expression in the human and mouse developing urinary tract. Among these genes, DLG1 and KIF12 are likely novel susceptibility genes for CAKUT in humans (Kidney Int 2015).Here we propose to initially characterize the function of novel CAKUT candidate genes during embryonic development, nephrogenesis and ureteric development. We will first study the candidate genes temporal-spatial expression and colocalization profile during different stages of embryogenesis in normal mouse and human embryonic tissue and in developing kidneys and urinary tract and compare to markers of nephrogenesis and ureteric development. We will next choose one high-priority novel candidate gene and generate and characterize mouse harboring mutation in a gene of interest (knockout mice) to identify the mechanisms by which mutations in this gene lead to urinary tract malformations in humans. This study is designed to characterize the functional effect of CAKUT candidate genes in urinary tract development, to identify dysregulated pathways, and, ultimately, to devise novel diagnostic tool and therapeutic strategies for this common form of renal failure.]]></summary_en></project><project>
<id>4089</id><title_hr><![CDATA[Sinteza naprednih anorganskih katalizatora s povećanim brojem kiselih mjesta]]></title_hr><title_en><![CDATA[Synthesis of Advanced Inorganic Catalysts of Increased Number of Acid Sites]]></title_en><user_id>609</user_id><user_firstLast_name>Josip Bronić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-2214</code><acronim><![CDATA[SAdInCat]]></acronim><duration>01.03.2017 - 31.12.2021</duration><status>Završio</status><financ_value>122.635,87 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>5634, 692, 623, 1073, 19249, 19656, 25291, 28957, </team_members_id><team_members_names><![CDATA[Tatjana Antonić Jelić, Sanja Bosnar, Andreas Puškarić, Stjepko Krehula, Girolamo Giordano, Boris Subotić, Glorija Medak, Ivana Landripet, ]]></team_members_names><keywords_hr><![CDATA[zeolitni katalizatori, hijerarhijski zeoliti, hibridni materijal, nano-zeoliti, mokra impregnacija, converzija metanola u olefine, ]]></keywords_hr><keywords_en><![CDATA[zeolite catalyst, hierarchical zeolites, hybrid materijal,  nano-zeolites, wet impregnation, methanol to olefin conversion, ]]></keywords_en><summary_hr><![CDATA[Zeoliti su mikroporozni alumino-silikatni materijali vrlo dobro definirane kristalne strukture i termičke stabilnosti. Zahvaljujući svojoj strukturi, kanali i otvori pora mogu biti raznih veličina (0.2-1.3 nm) i oblika. Broj dostupnih Lewis-ovih (kadkad i Bronsted-ovih) kiselih mjesta na čvrstim katalzatorima, kao što su zeoliti, je od najveće važnosti za efikasnost katalizirane organske reakcije. U cilju razjašnjenja utjecaja različitih zeolitnih struktura (MFI, MOR, BEA, FAU) na katalitička svojstva za pretvorbu metanola u olefin, sintetizirat će se kristali različitih zeolita (ZSM-5, mordentie, beta, ZY) mikrometarske veličine. Poboljšanje njihovih katalitičkih mogućnosti će se realizirati sustavnim studiranjem preko dva pristupa: - povećanjem dostupne površine na kristalima i - povećanjem broja kiselih mjesta.Površina kristala može se povećati kroz redukciju njihove veličine (kroz sintezu nanometarskih kristala) ili pravljenjem većih pora na kristalima mikrometarske veličine. Mezoporoznost kristala će se postići sintezom hierarhijskih zeolita koristeći dva (ili više) templata za sintezu, kao i tehnikom dealuminacije/desilikacije. Drugi način povećanja broja kiselih mjesta u pripravljenim zeolitima je uvođenje određenih kationa metala (Ti, Zr, Fe, Sn) koristeći ionsku zamjenu u čvrstom stanju metodom mljvenja i/ili mokrom impregnacijom. Broj katalitičkih kiselih mjesta će se određivati uporabom vacuum FTIR spektroskopije adsorbiranog piridina ili sličnih organskih molekula.Dodatni post-sintetski tretman pripravljenih hierarhijskih zeolita, provodit će se ugradnjom nanometarskih čestica metalnih-oksida (priređenih sol-gel postupkom) u njih da čine hibridne (kompozitne) katalizatore. Mnoge tehnike/metode će se koristiti za karakterizaciju strukturnih, čestičnih i katalitičkih svojstava uzoraka: PXRD, AAS, OM, SEM, TEM, LLS, FTIR, DR-UV/Vis, NMR, TG-DTG, N2 adsorption/desorption, PALS.]]></summary_hr><summary_en><![CDATA[Zeolites are microporous alumino-silicate materials of very well defined crystal structure and thermal stability. Due to their structure, a crystal channels and pore openings can be of various size (0.2-1.3 nm) and shape.The number of available Lewis&#39; (sometimes Bronsted) acid sites at solid state catalysts, such as zeolites, is crucial for efficiency of catalysed organic reactions. In order to elucidate the role of different zeolite structures (MFI, MOR, BEA, FAU) on catalytic properties for methanol to olefin conversion, various micrometer sized zeolite crystals (ZSM-5, mordentie, beta, ZY) will be synthesized. Improvement of their catalytic abilities will be realized by systematic study via two approaches: - increase of available surface at crystals, and - increase of the number of acid sites.The crystals surface can be enlarged through reduction of its size (by synthesis of nanometer sized crystals) or by creation of larger pores on micrometer sized crystals. Mesoporosity of the crystals will be obtained by synthesis of hierarchical zeolites using dual (or multi) template synthesis and by dealumination/desilication technique. Another way to increase the number of acid sits in prepared zeolites is introduction of certain metal cations (Ti, Zr, Fe, Sn) exploiting solid state ion exchange via grinding or/and via wet impregnation. The number of catalytic acid sites will be determined using vacuum FTIR spectroscopy of adsorbed pyridine or similar probe molecules.Additional post-synthesis treatment of obtained hierarchical zeolites will be done through incorporation of the nanometer sized metal-oxides (obtained by sol-gel method) to form hybrid (composite) catalyst. Many techniques/methods will be used for characterization of samples structural, particulate and catalytic properties, such as: PXRD, AAS, OM, SEM, TEM, LLS, FTIR, NMR, DR-UV/Vis, TG-DTG, N2 adsorption/desorption, PALS.]]></summary_en></project><project>
<id>4097</id><title_hr><![CDATA[Monitoring rezistentnosti štetnika: nove metode detekcije i učinkovite strategije upravljanja rezistentnošću]]></title_hr><title_en><![CDATA[Monitoring of Insect Pest resistance: Novel Approach for Detection and Effective Resistance Management Strategies]]></title_en><user_id>12674</user_id><user_firstLast_name>Renata Bažok</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-7458</code><acronim><![CDATA[MONPERES]]></acronim><duration>01.03.2017 - 14.08.2021</duration><status>Završio</status><financ_value>132.497,18 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Biotehnologija, Poljoprivreda, </scie_field_hr><scie_field_en>Biotechnology, Agriculture, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Agronomski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Agriculture]]></institution_en><team_members_id>19312, 12814, 12868, 12867, 19317, 12781, 12863, 13560, 19319, 24311, 24310, 855335, </team_members_id><team_members_names><![CDATA[Božena  Barić, Dinka Grubišić, Darija Lemić, Maja Čačija, Ivana Pajač Živković, Hugo Benitez, Katarina Mikac, Tóth Miklós, Helena Virić Gašparić, Martina Kadoić Balaško, Dijana Fuchs, Bastian Christoph Goldel, ]]></team_members_names><keywords_hr><![CDATA[biotest, metode detekcije, genetski monitoring, geometrijsko morfometrijska analiza, rezistentnost štetnika, upravljanje rezistentnošću]]></keywords_hr><keywords_en><![CDATA[ bioassay, detection methods, genetic monitoring, geometric morphometric analyse, pest resistance, restitance management strategies                   ]]></keywords_en><summary_hr><![CDATA[Proizvodnju važnih kultura u Hrvatskoj (kukuruz, krumpir i jabuka) ugrožavaju brojni štetnici, od kojih su najvažniji kukuruzna zlatica (Diabrotica virgifera virgifera LeConte) (WCR), krumpirova zlatica (Leptinotarsa decemlineata Say) (CPB) i jabukov savijač (Cydia pomonella L.) (CM). Navedene vrste razvile su rezistentnost na insekticide ili na strategije suzbijanja. Sustavno praćenje rezistentnosti štetnika u Hrvatskoj ne postoji. Za dokazivanje rezistentnosti uobičajeno se koriste biotestovi, biokemijski i molekularni testovi koji imaju određene prednosti, ali i nedostatke.Opći cilj predloženog projekta je otkriti i pratiti rezistentne populacije štetnika u Hrvatskoj, optimizirati genetske metode i istražiti pouzdanost geometrijsko-morfometrijskih metoda u otkrivanju rezistentnosti, te održati učinkovito suzbijanje uporabom odgovarajućih antirezistentnih strategija usmjerenih na najvažnije štetnike ratarskih (WCR, CPB) i voćarskih (CM) kultura.Specifični ciljevi projekta su:O1) u poljskim uvjetima Hrvatske organizirati sustavni monitoring rezistentnosti CPB i CM; O2) optimizirati genetske metode za otkrivanje varijabilnosti povezanih s razvojem rezistentnosti WCR, CPB i CM;O3) istražiti mogućnost korištenja geometrijsko-morfometrijskih metoda za otkrivanje razvoja rezistentnosti istraživanih štetnika;O4) utvrditi mogućnost korištenja alternativnih metoda suzbijanja; O5) osigurati prijenos znanja i spoznaja do ključnih interesnih skupina. Očekivani rezultati: R1) osigurani pouzdani podaci o pojavi i distribuciji rezistentnih populacija CPB i CM u Hrvatskoj; R2) istražene, razvijene i optimizirane genetske i R3) geometrijsko-morfometrijske metode za otkrivanje i praćenje nerezistentnih i rezistentnih populacija CPB, WCR i CM; R4) osigurani podaci o alternativnim (uključujući nekemijske) metodama i strategijama suzbijanja i R5) stečena znanja i spoznaje predočene interesnim skupinama. Osigurana potpora provedbi novo razvijenih strategija u poljoprivrednu praksu.]]></summary_hr><summary_en><![CDATA[The production of the important crops, maize, potato and apples in Croatia is endangered by many of insect pests out of which very important are Western corn rootworm (Diabrotica virgifera virgifera LeConte) (WCR), Colorado potato beetle (Leptinotarsa decemlineata Say) (CPB) and Codling moth (Cydia pomonella L.) (CM). These pests have shown resistance to insecticides or to management strategies. No systematic monitoring of pest resistance is carried out in Croatia. Methods available for resistance detection  (bioassays, biochemical or molecular) have positive and negative points. The main objective is to detect and monitor the resistant variants in Croatia, optimize genetic and explore reliability of morphometric based survey techniques for the detection of resistance, and to maintain effective control using appropriate resistance manageemnt strategies of WCR, CPB and CM. Specific objectives are: O1) to conduct systematic field monitoring of resistance in CPB  and CM in Croatia; O2) to optimize techniques to detect genetic differentiation correlated with resistance development in WCR, CPB and CM; O3) to explore the potential of geometric morphometric techniques in order to detect resistance development in investigated pests;O4) to establish the potential for use of alternative control options for investigated pests.O5) to disseminate gained knowledge to key stakeholders The expected results are: R1 provided reliable data on the presence and distribution of resistant variants of CPB and CM in Croatia; R2) The genetic and R3) morphometric based survey techniques to detect and monitor the movement of non-resistant and resistant variants of CPB, WCR and CM explored, developed and optimized; R4) the summarized information on alternative (including non-chemical) control options and strategies provided and R5) The gained knowledge disseminated to key stakeholders. Provided support to implementation of newly developed strategies into the agricultural practice.]]></summary_en></project><project>
<id>4101</id><title_hr><![CDATA[Metodološki okvir za učinkovito upravljanje energijom s pomoću inteligentne podatkovne analitike]]></title_hr><title_en><![CDATA[Methodological Framework for Efficient Energy Management by Intelligent Data Analytics ]]></title_en><user_id>6088</user_id><user_firstLast_name>Josip Mesaric</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-8350</code><acronim><![CDATA[MERIDA]]></acronim><duration>01.01.2017 - 28.02.2021</duration><status>Završio</status><financ_value>73.217,07 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, </scie_field_hr><scie_field_en>Economy, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Ekonomski fakultet u Osijeku]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Economics]]></institution_en><team_members_id>895, 2941, 6088, 20226, 20250, 2550, 6717, 6410, 6353, 25355, 26583, 855430, </team_members_id><team_members_names><![CDATA[Rudolf Scitovski, Hrvoje Krstić, Josip Mesaric, Davor Dujak, Zlatko Tonković, Domagoj Sajter, Dario Šebalj, Adela  Has, Saša Mitrović, Marinela Knežević, Sanja Scitovski, Kristina Hodak, ]]></team_members_names><keywords_hr><![CDATA[podatkovna analitka, strojno učenje, energetska učinkovitost, troškovi energije, lanac opskrbe, simulacije, metodološki okvir]]></keywords_hr><keywords_en><![CDATA[data analytics, machine learning, energy efficiency, energy cost, energy supply chain, simulation, methodological framework]]></keywords_en><summary_hr><![CDATA[Iako u Hrvatskoj i u drugim zemljama EU postoje strategije i nacionalni planovi energetske učinkovitosti kojima se određuju i prate ciljevi smanjenja potrošnje energije,  podaci se nedovoljno znanstveno analiziraju u svrhu učinkovitijeg upravljanja energijom, a posebice nedostaje uporaba metoda strojnog učenja. Upravo je svrha projekta provesti inteligentnu analizu podataka o energetskoj učinkovitosti zgrada u javnom sektoru, ponuditi metode i modele koji bi omogućili bolje planiranje nacionalne energetske politike te upravljanje troškovima. Ciljevi projekta su: (1) identificirati karakteristične skupine (klastere) javnih zgrada za koje se prate energetske karakteristike, mjere za poboljšanje tih karakteristika i potrošnja energije, (2) uporabom podatkovne analitike razviti metodološki okvir za  predviđanja i analizu utjecaja pojedinih varijabli na uštede u potrošnji energije, emisiji CO2 i troškovima, (3) naprednim analitičkim metodama procijeniti financijsku isplativost i dugoročne financijske učinke mjera za povećanje energetske učinkovitosti i (4) simulacijskim modeliranjem predložiti prilagodbe modela lanca opskrbe prirodnog plina kao jednog od važnijih energenata u javnom sektoru. Za dobivanje modela testirat će se metode strojnog učenja, kao što su klaster analize, neuronske mreže, stabla odlučivanja, metoda potpornih vektora i druge, zatim financijske metode, mapiranje lanca opskrbe i simulacijsko modeliranje. Statističkim testovima izabrat će se metode koje generiraju preciznije modele i predložiti njihova integracija u nov metodološki okvir kao znanstveni doprinos projekta.  Osim toga, otkrit će se utjecaj pojedinih ulaznih varijabli na potrošnju energije i trošak te stvoriti jedinstvena baza podataka energetske učinkovitosti koja će služiti i za buduće analize. Osim istraživača, korisnici ovog projekta mogu biti državne institucije davatelji subvencija, donositelji i provoditelji energetske politike, korisnici zgrada i pružatelji energetskih usluga.]]></summary_hr><summary_en><![CDATA[Although there are strategies and national plans of energy efficiency in Croatia and other EU countries, which determine and monitor the objectives of reducing energy consumption, the data have not been scientifically analyzed enough for the purpose of efficient energy management, and there is a lack of machine learning methods usage.  The purpose of the project is to conduct an intelligent data analysis on public buildings energy efficiency, and to suggest methods and models that will enable better planning of national energy policy. The aims of the project are: (1) to identify characteristic clusters of public buildings for which data on energetic characteristics, measures for improving those characteristics, and energy consumption are captured, (2) to develop a methodological framework for predictions and analyses of variable influence on energy consumption, CO2 emission and cost, by using intelligent data analytics,  (3) to estimate financial compensation and long-term financial effects of measures for increasing energy efficiency by advanced analytical methods, and (4) to suggest improvements in supply chain of natural gas as one of the important energy sources in building sector. In order to obtain models, methods of machine learning will be tested such as cluster analysis, neural networks, decision trees, support vector machines, and others, as well as financial methods, supply chain mapping, and simulation modelling.  By using statistical tests, the more successful methods will be suggested for integration in the methodological framework that will be the major scientific contribution. In addition, the influence of specific input variables on energy consumption and cost will be revealed, and a unique database of energy efficiency will be established that could be used for future data analyses. Besides researchers, the users of this project could be state institutions providers of subventions, policy makers, managers in public sector, and energy providers.]]></summary_en></project><project>
<id>4103</id><title_hr><![CDATA[Operatori na C*-algebrama i Hilbertovim modulima]]></title_hr><title_en><![CDATA[Operators on C*-algebras and Hilbert modules]]></title_en><user_id>19162</user_id><user_firstLast_name>Damir Bakić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-1046</code><acronim><![CDATA[OCAHM]]></acronim><duration>15.03.2017 - 14.03.2021</duration><status>Završio</status><financ_value>64.000,27 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>19272, 19294, 7717, 19465, 19498, 19437, 19270, 19374, </team_members_id><team_members_names><![CDATA[Ljiljana Arambašić, Tomislav Berić, Dijana Ilišević, Ilja  Gogić, Pavle Goldstein, Boris Guljaš, Rajna Rajić, Luka Žunić, ]]></team_members_names><keywords_hr><![CDATA[C*-algebra, Hilbertov C*-modul, derivacija, automorfizam, lokalni multiplikator, elementaran operator, bazni okvir, ortogonalnost, Wignerova jednadžba]]></keywords_hr><keywords_en><![CDATA[C*-algebra, Hilbert C*-module, derivation, automorphism, local multiplier, elementary operator, frame,  orthogonality, Wigner&#39;s equation]]></keywords_en><summary_hr><![CDATA[U predloženom projektu istraživat ćemo neke klase operatora na C*-algebrama i Hilbertovim C*-modulima. Prvo, istraživat će se skupovi derivacija, automorfizama i elementarnih operatora na jediničnim C*-algebrama; posebno, međusobni odnosi zatvarača tih skupova u operatorskoj i potpuno ograničenoj (cb) normi. Vezani dio istraživanja je analiza elementarnih operatora na Hilbertovim C*-modulima. Namjeravamo naći prikladna poopćenja formula (poznatih za C*-algebre) za normu i cb-normu takvih operatora u terminima njihovih koeficijenata. Također namjeravamo studirati neke druge klase operatora na C*-algebrama i Hilbertovim C*-modulima: operatore &#39;&#39;konačnog ranga&#39;&#39; i aproksimacije takvim operatorima, n-cirkularne projektore te unitarne/antiunitarne operatore (u vezi s generalizacijama i analizom stabilnosti Wignerove jednadžbe). Povezano područje koje namjeravamo istražiti je klasa preslikavanja na C*-algebrama i Hilbertovim C*-modulima koja čuvaju ortogonalnost s obzirom na različite koncepte ortogonalnosti.U našem proučavanju operatora na Hilbertovim C*-modulima namjeravamo koristiti bazne okvire i vanjske bazne okvire takvih modula kao osnovni alat. Vanjski bazni okviri Hilbertovih C*-modula nedavno su uvedeni i prepoznati kao prirodno popćenje baznih okvira koje popunjava neke praznine u modularnoj teoriji baznih okvira. Planiramo sistematično koristiti egzistenciju baznih okvira i vanjskih baznih okvira u svim prebrojivo generiranim modulima i njihovo rekonstrukcijsko svojstvo kako bismo stekli novi uvid u transformacije modula i strukturu skupova nekih klasa modularnih preslikavanja. Konačno, namjeravamo se posvetiti i nekim otvorenim pitanjima u samoj teoriji modularnih baznih okvira poput korespondencije ograničenih preslikavanja i Besselovih nizova, perturbacija baznih okvira i opisa (zajedno s metodama konstrukcije) dualnih baznih okvira s posebnim svojstvima.]]></summary_hr><summary_en><![CDATA[In the proposed project we shall study some classes of operators on C*-algebras and Hilbert C*-modules. First, we will study the sets of derivations, automorphisms and elementary operators on unital C*-algebras; in particular, the interrelations of the closures of these sets in the operator and completely bounded (cb) norm. A related part of the project is the analysis of elementary operators on Hilbert C*-modules. We aim to find appropriate generalizations of formulae (known for C*-algebras) for the norm and cb-norm of such operators in terms of their coefficients.  We also plan to study some other classes of operators on C*-algebras and Hilbert C*-modules: &#39;&#39;finite rank&#39;&#39; operators and approximations by such operators, n-circular projections, and unitary/anti-unitary operators (in connection with generalizations and analysis of the stability of Wigner&#39;s equation). A related topic which we aim to explore is the class of orthogonality preserving maps on C*-algebras and Hilbert C*-modules, with respect to various concepts of orthogonality. In our study of operators on Hilbert C*-modules we plan to use frames and outer frames for such modules as a pivotal tool. Recently, outer frames for Hilbert C*-modules are introduced and recognized as a natural generalization of frames that bridges some gaps in the modular frame theory. We plan to use systematically the existence of frames and outer frames in all countably generated modules and their reconstruction property to obtain a new insight into the properties of transformations of Hilbert C*-modules and into the structure of sets of some classes of modular maps. Finally, we aim to address some open questions in the modular frame theory itself such as the correspondence of bounded operators and Bessel sequences, perturbations of frames and description (together with construction methods) of dual frames with special properties.]]></summary_en></project><project>
<id>4108</id><title_hr><![CDATA[Vrijednosti i odluke na kraju života]]></title_hr><title_en><![CDATA[Values and Decisions at the End of Life]]></title_en><user_id>5397</user_id><user_firstLast_name>Ana Borovečki</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-2721</code><acronim><![CDATA[VAL-DE-END]]></acronim><duration>01.09.2017 - 28.02.2022</duration><status>Završio</status><financ_value>51.297,37 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo, Društvene znanosti, Humanističke znanosti, </scie_area_hr><scie_area_en>Biomedicine and health sciences, Social sciences, Humanities, </scie_area_en><scie_field_hr>Integrativna bioetika, Javno zdravstvo i zdravstvena zaštita, Sociologija, Psihologija, Filozofija, Religijske znanosti, </scie_field_hr><scie_field_en>Integrative bioethics, Public health and health services, Sociology, Psychology, Philosophy, Religion, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>5444, 5528, 5586, 5993, 6105, 5826, 5452, 19271, 19284, 6204, 19295, 19283, 19382, 19472, 25062, 25041, 25013, 25060, </team_members_id><team_members_names><![CDATA[Lovorka Brajković, Hrvoje Premuž, Marko Ćurković, Suzana Vuletić, Bert Gordijn, Sanja Babić-Bosanac, Stjepan Oreskovic, Diana Špoljar, Chris Gastmans, Tonci Matulic, Marijana Braš, Štefan Grosek, Milivoj Novak, Dinko Tonković, Filip Rubić, Boris Filipović-Grčić, Ružica Kramarić, Sunčana Janković, ]]></team_members_names><keywords_hr><![CDATA[vrijednosti, odluke,  kraj života, jedinice intenzivne skrbi, bioetika]]></keywords_hr><keywords_en><![CDATA[values, decisions, end of life, ICU, bioethics]]></keywords_en><summary_hr><![CDATA[ETHICUS studija provedena od 1999-2003 godine pokušala je dati odgovor o odlukama vezanim uz kraj života u jedinicama intenzivne skrbi u Europskim zemljama koje su bile dio studije. Hrvatska nije bila dijelom te studije niti su ikada istraživane vrijednosti i odluke vezane uz kraj života u jedinicama intenzivne skrbi u hrvatskom zdravstvenom sustavu. Tercijarna razina zdravstvene zaštite najviša je razina pružanje zdravstvenih usluga i razina na kojoj se rješavaju svi kompleksni slučajevi u Republici Hrvatskoj. Tako nije čest slučaj da se u intenzivnim jedinicama na toj razini zdravstvene zaštite donose složene odluke vezane za kraj života. Cilj je ovog projekta istražiti donošenje odluka vezanih uz kraj života u jedinicama intenzivne skrbi u bolnicama na tercijarnoj razini zdravstvene zaštite ( klinike, kliničke bolnice, klinički bolnički centri) u Republici Hrvatskoj te analizirati sustav vrijednosti liječnika i medicinskih sestara. Za potrebu postizanja ovih ciljeva oformljen je interdisciplinaran istraživački tim s iskustvom u sličnim istraživanjima. Kroz niz retrospektivnih i prospektivnih istraživanja kvantitativnog i kvalitativnog tipa pokušat će se dobiti podatke o donošenju odluka na kraju života u jedinicama intenzivne skrbi u Republici Hrvatskoj. Također će se kroz istraživanje na reprezentativnom uzroku stanovništva republike Hrvatske pokušati vidjeti koji su stavovi i vrijednosti vezani uz odluke na kraju života koji su dominanti među hrvatskom populacijom. Na kraju će se pokušati predložiti smjernice za donošenja odluka na kraju života u jedinicama intenzivne skrbi u Republici Hrvatskoj. ]]></summary_hr><summary_en><![CDATA[ETHICUS study (1999-2003) tried to give an answer on decisions related to the end of life in intensive care units in European countries that were part of the study. Croatia was not part of the study, nor was ever a research into values and decisions related to the end of life in intensive care units in the Croatian health system undertaken. The tertiary level of health care is the highest level of provision of health services and the level at which all complex cases in the Republic of Croatia as solved. So is often the case that in the intensive care units at this level of health care complex decisions about end of life are made. The aim of this project is to study decision-making related to the end of life in intensive care units in hospitals at the tertiary level health care (clinics, clinical hospitals, clinical hospital centres) in Croatia and analyse the value system of doctors and nurses. For the purpose of achieving these goals an interdisciplinary research team with experience in similar studies was created. Through a series of retrospective and prospective studies of quantitative and qualitative type will try to get information about the decision-making at the end of life in intensive care units in Croatia. A research on the representative sample of general population of the Republic Croatia will be performed in order to see what are the attitudes and values related to the decisions at the  end life that are dominant in the Croatian population. At the end will try to propose guidelines for decision-making at the end of life in intensive care units in Croatia. ]]></summary_en></project><project>
<id>4117</id><title_hr><![CDATA[Napredni senzorski sustavi za precizno navodnjavanje u krškom krajobrazu]]></title_hr><title_en><![CDATA[Advanced sensor systems for precision irrigation in karst landscape]]></title_en><user_id>18912</user_id><user_firstLast_name>Vedran Bilas</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-8379</code><acronim><![CDATA[SENSIRRIKA]]></acronim><duration>01.03.2017 - 28.02.2021</duration><status>Završio</status><financ_value>132.209,17 eur</financ_value><scie_area_hr>Tehničke znanosti, Biotehničke znanosti, </scie_area_hr><scie_area_en>Technological sciences, Biotechnical sciences, </scie_area_en><scie_field_hr>Elektrotehnika, Poljoprivreda, </scie_field_hr><scie_field_en>Electrical engineering, Agriculture, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>12596, 19282, 19313, 19300, 19274, 19772, 25240, 27218, </team_members_id><team_members_names><![CDATA[Darko Vasić, Hrvoje Džapo, Monika Zovko, Davorin Ambruš, Dinko Oletić, Guido D&amp;#39;Urso, Marko Gazivoda, Martincic Emile, ]]></team_members_names><keywords_hr><![CDATA[senzori, niska cijena, niska potrošnja, tlo, biljka, voda, poljoprivreda, Mediteran, održivost]]></keywords_hr><keywords_en><![CDATA[sensors, low-cost, low power, soil, plant, water, agriculture, Mediterranean, sustainability]]></keywords_en><summary_hr><![CDATA[Krški krajobraz je poljoprivredni potencijal primorskih i otočnih područja, posebice za proizvodnju grožđa i maslina. Unatoč povoljnim klimatskim uvjetima, uslijed konfiguracije terena i strukture tla oborinske vode se ne zadržavaju u gornjim slojevima. Izvori vode u ovim krajevima su vrlo oskudni pa je njeno racionalno korištenje za navodnjavanje osobito važno. Precizno navodnjavanje primjenjuje potrebnu količinu vode na pravom mjestu i u pravo vrijeme čime raste kvaliteta plodova, smanjuju se troškovi i čuva okoliš. Za precizno navodnjavanje treba poznavati čimbenike tla, zraka i biljke te njihovu prostornu i vremensku promjenjivost. Opći cilj ovog projekta je doprinijeti održivosti poljoprivrede na mediteranskom kršu izloženom vodnom stresu. Vodna ravnoteža krškog tla se radi heterogenosti ne može odrediti komercijalnim senzorima te je prvi dio istraživanja usmjeren na razvoj naprednog elektromagnetskog senzora vlažnosti tla. Drugi dio istraživanja odnosi se na ekonomične senzore za motrenje vodne ravnoteže biljke koju treba određivati u gustom rasporedu radi prostorne varijabilnosti tla. Senzori koriste energiju iz okoline i iznimno su male potrošnje. Izvedeni su kao senzorski čvorovi bežične mreže čime se omogućuje fuzija senzorskih podataka cjelovite površine. Sustav je zasnovan na otvorenim komunikacijskim tehnologijama radi proširivosti i nadogradnje. Treći dio istraživanja odnosi se na agronomsku validaciju podataka demonstracijskog senzorskog sustava. U istraživanjima ćemo koristiti iskustva u navodnjavanju krških vinograda i maslinika, modeliranju elektromagnetskih svojstava tla i dizajnu naprednih elektromagnetskih senzora, primjeni bežičnih senzorskih mreža u poljoprivredi, projektiranju senzorskih sučelja s iznimno malom potrošnjom, razvoju napajanja energijom iz okoline te razvoju umreženih ugradbenih sustava. Razvijeno rješenje ćemo demonstrirati u stvarnim uvjetima i prenijeti znanja i iskustva na stručnu javnosti i industriju. ]]></summary_hr><summary_en><![CDATA[Karst landscapes can provide cultivated land in Adriatic coast and islands, especially for grapevine and olive trees. The area benefits from Mediterranean climate, but due to terrain configuration and soil structure, rain water percolates rapidly downward. As freshwater sources are very scarce, their rational use for irrigation is of the greatest importance. Precision irrigation (PI) refers to application of accurately assessed volume of water at right place and time to improve crops quality, reduce costs and preserve environment. Implementation of PI requires knowledge of soil, air and plant factors in space and time. The overall objective of this project is to contribute to sustainability of agriculture in karst Mediterranean landscape providing water stress information for PI. Due to coarse nature of karst soil, its water balance cannot be estimated by commercial root zone soil moisture sensors. First part of the research aims to development of an advanced electromagnetic (EM) karst soil moisture sensor. Second part of the research refers to cost-effective sensors for plant water balance monitoring that need to be densely deployed due to high within-field variability of soil. The sensors are ultra low power and use energy harvesting. They form wireless sensor network providing sensor data integration over field area. The network uses open communication technologies enabling scalability and upgrading. In third part of the research data from a field demonstrator are agronomically validated. In this project we will use our expertise in irrigation of karst; modelling of EM soil properties and design of advanced EM sensors; application of wireless sensor networks in agriculture; and design of ultra low power sensor interfaces, energy harvesting systems and networked embedded systems. We will demonstrate the developed system in field and transfer the knowledge and experiences to professional community and industry.]]></summary_en></project><project>
<id>4122</id><title_hr><![CDATA[Modernizacija urbanog života u Hrvatskoj kroz prizmu razvoja komunalne infrastrukture u 19. i 20. stoljeću]]></title_hr><title_en><![CDATA[The Modernisation of Urban Life in Croatia Considered through the Development of Municipal Infrastructure in the 19th and 20th Centuries]]></title_en><user_id>18907</user_id><user_firstLast_name>Marino Manin</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-2015</code><acronim><![CDATA[MOZIRA]]></acronim><duration>01.03.2017 - 31.07.2021</duration><status>Završio</status><financ_value>55.584,98 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Povijest, </scie_field_hr><scie_field_en>History, </scie_field_en><institution_hr><![CDATA[Hrvatski institut za povijest]]></institution_hr><institution_en><![CDATA[Croatian Institute of History]]></institution_en><team_members_id>19904, 20267, 6092, 20095, 20287, 1361, </team_members_id><team_members_names><![CDATA[Lidija Bencetić, Kristina Milković Šarić, Mario Bara, Tomislav  Anić, Goran Rajič, Hrvoje Čapo, ]]></team_members_names><keywords_hr><![CDATA[urbanizacija, modernizacija, komunalna infrastruktura, Zagreb, Hrvatska]]></keywords_hr><keywords_en><![CDATA[urbanization, modernization, municipal infrastructure, Zagreb, Croatia ]]></keywords_en><summary_hr><![CDATA[Pri obradi tematike predložene projektnim prijedlogom, polazište istraživača biti će demografske analize, rezultati gospodarskih povjesničara o procesu modernizacije u Hrvatskoj i raspoloživi podaci o komunalnoj infrastrukturi u gradovima (plinska i električna rasvjeta, uređenje ulica, razvoj vodovodne i kanalizacijske mreže, javnoga prometa, zbrinjavanje otpada i održavanje javnih površina, te telefonska mreža), a pristupiti će istraživanju arhivskih izvora u svrhu sagledavanja odnosa između razvoja komunalne infrastrukture i osuvremenjivanja načina života građana (od kretanja po gradu i komunikacije, preko promjena u načinu spremanja i čuvanja hrane, do osobne higijene i organizacije dana). U središtu istraživanja biti će grad Zagreb od njegovoga administrativnoga ujedinjenja 1850. godine do suvremenosti, a dobivene rezultate komparirati će se s infrastrukturnim rješenjima u drugim hrvatskim gradovima i to kako s regionalnim središtima (Rijeka, Split i Osijek), tako i s onima novonastalim zbog potreba gospodarstva (Borovo, Đurđenovac, Raša), a radna je hipoteza da su regionalne razlike u drugome planu, dok je daleko važniji tijek modernizacije i uvođenja inovacija. Istraživanje će donijeti više desetaka analitičkih radova za objavljivanje u znanstvenim časopisima u zemlji i inozemstvu, sudjelovanje na nizu znanstvenih skupova u zemlji i u inozemstvu, nekoliko znanstvenih monografija, kao i diseminaciju znanstvenih rezultata preko organizacije izložbe, radionica za studente i za građanstvo.]]></summary_hr><summary_en><![CDATA[In addressing the topics specified by the project proposal, the researchers will take the following as their starting points: demographic analysis, extensive work done by economic historians related to the process of modernisation in Croatia, and the available data on municipal infrastructure in cities (e.g., gas and electric lighting, street landscaping, the development of water supply and sewerage networks, public transport, waste disposal, the maintenance of public space, and the telephone network). Furthermore, the researchers will access archival sources, and attempt to establish and explain the relationship between the development of urban infrastructure and the impact it had on the modernisation of the everyday life of city dwellers (e.g., interurban mobility, communication, food storage and preparation, personal hygiene, daily routine, etc.). The research will focus on the City of Zagreb beginning with its administrative unification in 1850 and ending in the present time, while the results will be compared with the development of municipal infrastructure in other Croatian cities (both with important regional centres, such as Rijeka, Split and Osijek, and the newly built towns for special economic purposes, such as Borovo, Đurđenovac and Raša). The researchers’ working hypothesis is that regional disparities are not as important as modernisation itself and the introduction of innovations. The expected outcome of the research proposed will result in a dozen of analytical papers intended for publication in scientific journals both at home and abroad, participation in a series of both national and international scientific conferences, several scientific monographs, as well as the dissemination of scientific results through the organisation of exhibitions and workshops intended for both students and the general public.]]></summary_en></project><project>
<id>4123</id><title_hr><![CDATA[Hrvatski mrežni rječnik]]></title_hr><title_en><![CDATA[Croatian Web Dictionary]]></title_en><user_id>5199</user_id><user_firstLast_name>Lana Hudeček</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-2141</code><acronim><![CDATA[MREŽNIK]]></acronim><duration>01.03.2017 - 31.07.2021</duration><status>Završio</status><financ_value>78.298,76 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filologija, </scie_field_hr><scie_field_en>Philology, </scie_field_en><institution_hr><![CDATA[Institut za hrvatski jezik]]></institution_hr><institution_en><![CDATA[Institute of Croatian Language]]></institution_en><team_members_id>11223, 5200, 5768, 19088, 19110, 19099, 19104, 19128, 19328, 7777, 2966, 25202, 25351, 26889, </team_members_id><team_members_names><![CDATA[Kristian Lewis, Milica Mihaljević, Barbara Kovačević, Ermina Ramadanović, Ivana Matas Ivanković, Joža Horvat, Domagoj Vidović, Goranka Blagus Bartolec, Dinka Pasini, Željko Jozić, Bruno Nahod, Josip Mihaljević, Daria Lazić, Maja Matijević, ]]></team_members_names><keywords_hr><![CDATA[mrežni rječnik, hrvatski rječnik, jednojezični rječnik,  hipertekstni rječnik, e-leksikografija, e- rječnik, rječnik utemeljen na korpusu]]></keywords_hr><keywords_en><![CDATA[web dictionary, Croatian dictionary, monolingual dictionary,  hipertext dictionary; e-leksicography, e- dictionary, corpus based dictionary]]></keywords_en><summary_hr><![CDATA[U okviru projekta Hrvatski mrežni rječnik (MREŽNIK) izradit će se slobodno dostupan, jednojezični, hipertekstni, jednostavno pretraživ mrežni rječnik hrvatskoga standardnoga jezika od 10 000 natuknica koji će omogućivati interakciju s korisnicima. Natuknice i pojedine riječi i izrazi u rječničkim člancima povezivat će se unakrižno i s natuknicama u bazama podataka koje će nastati u okviru ovoga projekta (baza jezičnih savjeta, baza veznika s opisom vezničkih skupina i njihove modifikacije, baza objašnjenja podrijetla frazema, baza etnika i ktetika). Uz osnovne, rječnik će uključivati i školske definicije (3000) i definicije za strance (1000). Rječnik će biti utemeljen na kopusu (Hrvatska mrežna riznica i Hrvatski mrežni korpus). Uz te će se izvore uzimati u obzir pri uspostavi definicija, donošenju primjera i značenja i svi drugi dostupni tiskani i mrežni izvori. Rječnik će se pisati u programu TLex, prilagođenu za potrebe projekta, a za uvid u korpus upotrijebit će se mrežni alat za pretragu korpusa SketchEngine. Nakon završetka leksikografske obradbe, podatci će biti izvezeni iz TLexa te izrađena mrežna aplikacija rječnika. U okviru projekta predviđena je: 1. izradba temeljnoga rječnika od 10 000 natuknica; 2. izradba popratnih baza i njihovo povezivanje s temeljnim rječnikom; 3. povezivanje temeljnoga rječnika s drugim mrežnim izvorima koji se trenutačno izrađuju u Institutu za hrvatski jezik i jezikoslovlje (bazom glagolskih  valencija, kolokacija, hrvatskoga strukovnog nazivlja, Repozitorijem hratskih metafora, mrežnim stranicama Bolje je hrvatski (bolje.hr)); 4. izradba odostražnoga rječnika.MREŽNIK je zamišljen kao dinamični rječnik koji nakon završetka projektnoga razdoblja otvara mogućnost daljnjega dopunjivanja.]]></summary_hr><summary_en><![CDATA[As a part of the MREŽNIK (Croatian Online Dictionary) project, the online monolingual dictionary of Standard Croatian language with ten thousand dictionary entries will be compiled. The dictionary will be free, easy to search, it will allow interaction with users and will contain hypertext links. The dictionary entries will contain links to certain other words, expressions and repositories (Linguistic Advice Repository, Conjunction Repository, etc.). The dictionary will be corpus based (Croatian Language Repository and Croatian Web Corpus), but other sources, online and printed, will be taken into account when looking for example sentences and writing entry definitions.The dictionary will be compiled using TLex, a professional software application for compiling dictionaries. SketchEngine will be used to search the corpus. After the completion of the dictionary entries, the data will be exported from TLex, and the Web application will be developed.   The project will:1. compile the basic dictionary consisting of ten thousand entries;2. develope additional repositories and connect them with the basic dictionary; 3. connect the basic dictionary with other online resources which are currently being developed at the Institute of Croatian Language and Linguistics: (The Verb Valence Repository, The Collocation Repository, The Croatian Special Field Terminology of Croatian repository (Struna), The Etymological Dictionary of Croatian, The Croatian Metaphor Repository, website bolje.hr;4. compile a reverse dictionary.MREŽNIK is conceived as a dynamic dictionary, the development of which will not end at the end of the project.]]></summary_en></project><project>
<id>4125</id><title_hr><![CDATA[Održivost javnih financija na putu u monetarnu uniju]]></title_hr><title_en><![CDATA[Public finance sustainability on the path to the monetary union]]></title_en><user_id>3265</user_id><user_firstLast_name>Hrvoje Šimović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-4609</code><acronim><![CDATA[PuFiSuMU]]></acronim><duration>12.12.2016 - 12.03.2020</duration><status>Završio</status><financ_value>25.152,96 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, </scie_field_hr><scie_field_en>Economy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Ekonomski fakultet u Zagrebu]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Economics and Business]]></institution_en><team_members_id>12739, 4043, 3555, 5884, 22597, 26392, </team_members_id><team_members_names><![CDATA[Paško Burnać, Mirna Dumičić, Milan  Deskar-Škrbić, Tomislav Ćorić, Antonija Buljan, Marija  Davidović, ]]></team_members_names><keywords_hr><![CDATA[Fiskalna održivost, monetarna unija, javni dug, fiskalni multiplikatori, narativni pristup, mala i otvorena ekonomija, model opće ravnoteže, Hrvatska]]></keywords_hr><keywords_en><![CDATA[Fiscal sustainability, monetary union, public debt, fiscal multipliers, narrative approach, small and open economy, general equilibrium models, Croati]]></keywords_en><summary_hr><![CDATA[U posljednjem desetljeću Hrvatska je prošla dinamičan ekonomski i politički put koji je bio obilježen sa šest godina recesije i ulaskom u EU. Navedeno razdoblje karakterizirala je neusklađenost ekonomskih politika i nedostatak konzistentne fiskalne politike uzrokovane političkom nestabilnosti (3 koalicijske Vlade, 4 premijera, 5 ministra financija), ali i sustavne nespremnosti Vlada na provođenje suštinske fiskalne konsolidacije. Diskrecijske mjere u najvećoj su se mjeri svodile na povećanje porezne presije radi smanjivanja deficita, dok se na rashodnoj strani provodila tzv. politika nečinjenja što je rezultiralo izostankom strukturnih reformi. Takva politika rezultirala je eksplozijom javnog duga (s 36% na 85% BDP-a od 2008-15). U međuvremenu je snižen kreditni rejting na špekulativnu razinu te je aktiviran postupak prekomjernog deficita (EDP) i postupak prekomjernih makroekonomskih neravnoteža (MIP). U uvjetima slabog rasta (oko 2%) i fiskalne neodrživosti (kamate iznose oko 3,5% BDP-a), nositeljima ekonomske politike posao dodatno otežava činjenica da Hrvatska u svojoj europskoj perspektivi ima obavezu uvođenja Eura.Osnovi cilj predloženog projekta je analiza i evaluacija održivosti javnih financija u Hrvatskoj te projekcija dinamike javnog duga s ciljem postizanja potrebnih kriterija konvergencije i uvođenja Eura. Očekivani rezultati istraživanja dali bi cjelovitu sliku mogućnosti fiskalne i monetarne politike da u srednjem roku osvare preduvjete za ulazak Hrvatske u monetarnu uniju. Kao krajnji cilj trebalo bi se utvrditi optimalno razdoblje i tranzicijski trošak ulaska i uvođenje Eura, kao i sve ekonomske pretpostavke za ostvarivanje predloženog scenarija.]]></summary_hr><summary_en><![CDATA[In the last decade Croatia has experienced a dynamic economic and political path during which Croatia struggled with six years of recession and joined the EU. The observed period was characterized by uncoordinated economic policies and the lack of consistent fiscal policy partially due to the political instability (3 coalition governments, 4 Prime Ministers, 5 Ministers of Finance), but also because of the lack of government’s efforts to implement substantial fiscal consolidation. Discretionary measures were mainly conducted by increasing taxes in order to reduce the budget deficit, while government spending was led by the “policy of doing nothing” which resulted with the absence of structural reforms. Aforementioned policies resulted in public debt explosion (36% to 85% GDP in 2008-15). In the meanwhile, credit-rating was downgraded to the speculative level, and the EC activated Excessive deficit procedure (EDP) and Macroeconomic imbalances procedure (MIP). Need for fiscal consolidation in the period of slow economic growth (around 2%) and fiscal unsustainability (interest expenses amount to 3.5% of GDP) are even more challenging having in mind the fact that economic and political EU future includes (obligatory) adoption of the Euro. The overall goal of the proposed project is to analyse and evaluate Croatia’s public finance sustainability and to estimate public debt dynamics in order to fulfil convergence criteria and adopt the Euro. Expected results of this research should provide an overview of the possibilities of fiscal and monetary policies in the mid-term to create the preconditions for the Croatian accession to the EMU. The ultimate goal is to determine the target date for Croatia&#39;s accession, evaluate transition cost of adopting the Euro and to determine all economic requirements in order to achieve that goal. ]]></summary_en></project><project>
<id>4132</id><title_hr><![CDATA[Višegodišnje i dekadne oscilacije Jadranskog mora: opažanja, modeliranje  i posljedice]]></title_hr><title_en><![CDATA[The Adriatic interannual to decadal oscillations: observations, modelling and consequences]]></title_en><user_id>195</user_id><user_firstLast_name>Ivica Vilibić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-1955</code><acronim><![CDATA[ADIOS]]></acronim><duration>20.03.2017 - 19.03.2021</duration><status>Završio</status><financ_value>130.400,16 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Geofizika, </scie_field_hr><scie_field_en>Geophysics, </scie_field_en><institution_hr><![CDATA[Institut za oceanografiju i ribarstvo]]></institution_hr><institution_en><![CDATA[Institute of Oceanography and Fisheries]]></institution_en><team_members_id>357, 19180, 19158, 5979, 17732, 17848, 19409, 19884, 25204, </team_members_id><team_members_names><![CDATA[Ivica Janeković, Clea Denamiel, Manuel Bensi, Darko Koracin, Natalija Dunić, Slavko Radilović, Vedrana Kovačević, Samuel Somot, Petra Zemunik, ]]></team_members_names><keywords_hr><![CDATA[Jadransko more, višegodišnje i dekadske oscilacije, stvaranje guste vode, BIOS, združeno klimatsko modeliranje atmosfere i mora]]></keywords_hr><keywords_en><![CDATA[Adriatic Sea, interannual and decadal oscillations, dense water formation, BIOS regimes, coupled atmosphere/ocean climate modelling]]></keywords_en><summary_hr><![CDATA[Glavni cilj projekta Adios je istražiti i kvantificirati procese koji pogone međugodišnje i desetljetne termohaline varijacije u jadransko-jonskom bazenu. Cilj će se postići (i) dokumentiranjem međugodišnje i desetljetne varijabilnosti analizom dugoročnih oceanografskih mjerenja i postojećih klimatskih modela, (ii) istraživanjem kratkoročnih i dugogodišnjih procesa koji pokreću jadransko-jonsku termohalinu cirkulaciju, u prvom redu stvaranje guste vode u Jadranu i BIOS-a (Bimodalna jadransko-jonska oscilacija), i (iii) procjenom prošle i buduće jadranske klime i varijabilnosti primjenom jadranskog združenog (atmosfera-more) klimatskog modela visoke razlučivosti. Iako se odavno zna da je međugodišnja i desetljetna termohalina promjenjivost dominantna u Jadranu, odgovarajuća teorija (BIOS) razvijena je tek nedavno, te još uvijek nije ispravno reproducirana od strane oceanskih numeričkih modela. Stoga će se u okviru ADIOS projekta postaviti i pokrenuti ugniježđeni združeni klimatski model visoke rezolucije u području Jadrana. Nakon verifikacije nad mjerenjima, model će se primijeniti na buduću klimu koristeći nekoliko IPCC scenarija. Takav pristup omogućit će preciznu procjenu budućih klimatskih promjena na Jadranu, uključujući i višegodišnju i desetljetnu varijabilnost i regulirajuće procese, što će biti temelj za procjenu klimatskih rizika na nacionalnoj i regionalnoj razini. Značajan projektni napor će se posvetiti nastavku mjerenja na Palagruškom oceanografskom profilu, najdužem sezonski uzorkovanom oceanografskom transektu na Sredozemlju u trajanju od oko 60 godina, ali vrlo rijetko uzorkovanom nakon 2013. godine. ADIOS projekt će imati snažnu međunarodnu komponentu koja uključuje priznate oceanografske institute (OGS, CNRS-GAME), te njihove istraživače aktivno uključene na predviđena projektna istraživanja, što će rezultirati povećanjem kapaciteta, umreženosti i učinkovitosti hrvatske oceanografske i klimatske zajednice.]]></summary_hr><summary_en><![CDATA[The major objective of the ADIOS project is to investigate and to quantify processes driving interannual to decadal thermohaline variations in the Adriatic-Ionian basin. This objective will be achieved by (i) documenting interannual to decadal variability from long-term oceanographic series and existing climate models, (ii) investigating short- and long-time processes that drive the Adriatic-Ionian thermohaline circulation, primarily the Adriatic dense water formation and the BiOS (Adriatic-Ionian Bimodal Oscillating System), and (iii) assessing past and future Adriatic climate and variability from the Adriatic-adopted high-resolution atmosphere/ocean climate model runs. Although interannual to decadal thermohaline variability is known to be dominant in the Adriatic, the respective theory (cf. BIOS) has been developed very recently and is still not properly reproduced and verified by ocean numerical models. To tackle this, the Adriatic climate run will be setup and executed through nesting of state-of-the-art high-resolution atmospheric/ocean models into the Mediterranean runs. Once validated for a 30 year hindcast time period, the Adriatic model will be used in forecast mode for several IPCC scenarios. Such an approach will allow for better assessment of future climate changes in the Adriatic, including interannual to decadal variability and governing processes. These simulations will be a base for an upgrade in climate hazard assessment on national and basin levels. A significant project effort will be dedicated to continuation of the Palagruža Sill oceanographic transect, the longest seasonally-sampled transect in the Mediterranean, lasting over 60 years but very sparsely sampled since 2013. The project will have a strong international component, incorporating recognized institutes (OGS, CNRS-GAME) and their researchers to the ADIOS research and therefore increasing capacities, networks and efficiency of the Croatian oceanographic and climate communities.]]></summary_en></project><project>
<id>4133</id><title_hr><![CDATA[Struktura, funkcija i evolucija proteina Nme6/Nm23-H6]]></title_hr><title_en><![CDATA[Structure, Function and Evolution of Nme6/Nm23-H6 protein]]></title_en><user_id>1107</user_id><user_firstLast_name>Maja Herak Bosnar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-4021</code><acronim><![CDATA[Nemo6]]></acronim><duration>01.03.2017 - 30.11.2021</duration><status>Završio</status><financ_value>131.395,58 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>1322, 649, 1426, 22818, 25045, </team_members_id><team_members_names><![CDATA[Anđela Horvat, Neda Slade, Nikolina Škrobot Vidaček, Martina Radić, Bastien Proust, ]]></team_members_names><keywords_hr><![CDATA[Nm23, Nme, NDPK, NDK, supresor metastaziranja]]></keywords_hr><keywords_en><![CDATA[Nm23, Nme, NDPK, NDK, metastasis supressor]]></keywords_en><summary_hr><![CDATA[Nukleozid difosfatske kinaze (Nme/Nm23/NDPK) čine obitelj evolucijski očuvanih enzima, ključnih za odvijanje mnogo važnih bioloških procesa no njihova biokemijska funkcija nije još sasvim razjašnjena. Obitelj se sastoji od 10 članova podijeljenih u dvije skupine. Članovi Grupe I dosad su se intenzivno istraživali, posebice Nme1 u kontekstu formiranja metastaza te Nme2 koji je uključen u bolesti srca. Članovi Grupe I u ljudi pokazuju visok stupanj homologije unutar grupe kao i u usporedbi s ortolozima kod ostalih Metazoa. Posjeduju aktivnost NDPK ukoliko zauzmu oblik heksamera. Članovi Grupe II imaju znatno manji stupanj međusobne homologije te nemaju aktivnost NDPK, osim potencijalno protein Nme6, dok im multimerna struktura nije još utvrđena. Članovi Grupe II pojavili su se ranije tijekom evolucije, posebice Nme5, Nme6 i Nme7. O članovima Grupe II vrlo se malo zna, ali naši rezultati na genu/proteinu Nme6 kod spužve,Nme6Sd, upućuju na činjenicu da spužvin protein ima drugačije stanične funkcije nego njegov ljudski ortolog. Spužve smatramo živim fosilima i općenito se prihvaća teorija da se njihov genom i proteom nije znatno mijenjao posljednjih 500 milijuna godina te je sačuvao karakteristike genoma i proteoma pretka svih Metazoa. Predloženi projekt nastavlja se na naša prijašnja istraživanja na proteinima obitelji Nme kod ljudi i spužve, a usmjerit će se na rješavanje strukture te biokemijske i biološke funkcije ljudskog Nme6 i njegove promjene tijekom evolucije. U tu svrhu upotrijebit ćemo niz biokemijskih metoda koje ćemo poduprijeti metodama molekularne biologije i napredne konfokalne mikroskopije. Uvjereni smo da će naše istraživanje na Nme6 uvelike doprinijeti općem poznavanju obitelji gena/proteina te dati uvid u uloge njenih članova u glavnim bolestima današnjice. ]]></summary_hr><summary_en><![CDATA[Nucleoside-diphosphate kinases (Nme/Nm23/NDPK) are a family of evolutionary conserved enzymes involved in many crucial biological processes, but their biochemical functions have not yet been fully elucidated. The family consists of ten members divided in two groups of which the Group I has been extensively studied, especially the Nme1 in the context of metastasis formation and the Nme2 which appears to be involved in cardiac diseases. The Group I members in humans are generally highly homologous among themselves and in comparison to their orthologues in other Metazoans. They all possess the NDPK activity in their hexameric form. The Group II members display a lower level of mutual homology and, with a possible exception of Nme6, do not possess the NDPK activity, while their multimeric structure has not yet been revealed. The Group II members are evolutionary older, especially the Nme5, Nme6 and Nme7. Little is known about the Group II Nme members but our recent findings on Nme6Sd, the Nme6 gene/protein from marine sponge Suberites domuncula suggest that Nme6Sd has different cellular functions from its human orthologue. Sponges are regarded to be living fossils, and it is widely accepted that their genome and proteome structure did not change much in the last 500 million years. Therefore, they have probably preserved the genome and proteome structure of the common ancestor of all Metazoans. Building upon our previous work on the human and sponge Nme family of proteins, the proposed project will focus on resolving the structure and biochemical and biological functions of the human Nme6 and its changes during evolution. For this purpose we will employ a range of biochemical methods and combine them with modern molecular biology methods supported by advanced confocal microscopy techniques. We are confident that our research on the Nme6 will largely contribute to the knowledge on this gene/protein family in general and the roles of its members in major human diseases.]]></summary_en></project><project>
<id>4149</id><title_hr><![CDATA[Udobnost i antimikrobna svojstva tekstila i obuće]]></title_hr><title_en><![CDATA[Comfort and antimicrobial properties of textiles and footwear]]></title_en><user_id>4089</user_id><user_firstLast_name>Zenun Skenderi</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-5278</code><acronim><![CDATA[ComforMicrobTexFoot]]></acronim><duration>01.03.2017 - 31.12.2021</duration><status>Završio</status><financ_value>96.104,59 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Tekstilna tehnologija, </scie_field_hr><scie_field_en>Textile technology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Tekstilno-tehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Textile Technology]]></institution_en><team_members_id>4648, 4244, 19373, 405, 19372, 4097, 6964, 19362, 19919, 7338, 6722, 22458, 22481, 21364, 4173, 28975, 29056, </team_members_id><team_members_names><![CDATA[Zlatko Vrljičak, Alka Mihelić-Bogdanić, Jadranka Akalović, Tomislav Ivanković, Franka Žuvela Bošnjak, Dragana Kopitar, Antoneta Tomljenović, Beti Rogina-Car, Željka Pavlović, Lubos Hes, Sanja Ercegović Ražić, Jelena Peran, Tariq  Mansoor, Ivan Kraljević, Ivana Špelić, Juro Živičnjak, Suzana Mihanović, ]]></team_members_names><keywords_hr><![CDATA[Udobnost, pletivo, celuloza, nekonvencionalna pređa, bakterije, zaštita, obuća, koža, kompoziti]]></keywords_hr><keywords_en><![CDATA[Comfort, knitted fabric, nonconventional yarn, cellulose, bakterium, protection, footwear, leather, composite]]></keywords_en><summary_hr><![CDATA[Udobnost i antibakterijska svojstva tekstila za izradu odjeće koja priliježe uz kožu i obuće, za određenu vrstu i razinu aktivnosti te uvjete okoline, u najvećoj su mjeri određeni vrstom sirovine, strukturom i svojstvima tekstilnog plošnog proizvoda/kože, vrstom dorade te formom gotovog proizvoda odjeće/obuće koji se nosi. Kako bi se dobile nove spoznaje i dublje rasvijetlile povezanosti udobnosti i antibakterijskih svojtava sa svojstvima proizvoda, od sirovine, pređe, sirovog te sirovog i antibakterijski obrađeno pletiva, proizvesti će se triko predene nekonvencionalne pređe (rotorska i aerodinamička) iz umjetnih celuloznih vlakana, SIRO pređa iz viskoznih vlakana i prstenasta pređa iz pamuka poznatih karakteristika. Finoća svih predenih pređa je iz 10 tex × 2 (Nm100/2), dok je finoća SIRO pređe 10 tex × 2 (Nm100/2). Plesti će se pletiva u različitim vezovima. U pletiva za čarape dodavati će se PA multifilamentne pređe. Izraditi će se uzorci gotove kože (goveđa i teleća) za unutarnje dijelove gornjišta radne i zaštitne obuće, koji će biti obrađeni različitim vrstama štavila. Analizirati će se 3 uzorka, natur crust, doštavljeni crust uz istovremenu obradu antimikrobnim sredstvima te bojadisani crust uz nadoštavu i antimikrobnu obradu. Na svim uzorcima, pletiva te na uzorcima koža, odrediti će se objektivni parametri termofiziološke udobnosti (otpor prolazu topline i otpor prolazu vodene pare). Antimikrobna aktivnost svih uzoraka pletiva (antimikrobno tretirana) i koža, odrediti će se prema 3 vrste bakterija (A. baumannii, S. aureus i E. coli) koje se mogu naći u normalnoj fiziološkoj flori kože čovjeka, a koje mogu biti oportunistički patogeni. Odrediti će se i termofiziološka udobnost čarapa te radno zaštitne obuće proizvedene u domaćim tvornicama na Termalnom stopalu. Na jednom broju uzoraka kože (kromne i sintetske štave) provesti će se Komet test.]]></summary_hr><summary_en><![CDATA[Comfort and antibacterial properties of fabrics for making clothing worn next to the skin and footwear, for particular type and level of activity as well as environmental conditions are mostly determined by the type of raw material, structure and properties of fabric/leather, finishing process and shape of the final product, garment/footwear to be worn. In order to obtain new findings about comfort and antibacterial properties of products from raw materials, yarns, grey and grey and antibacterially treated knitted fabric, fabric will be made from conventional yarn (rotor-spun and aerodynamic yarn) made from man-made cellulosic fibres, SIRO yarns from viscose fibres and ring-spun yarn from cotton with known properties. The fineness of all spun yarns is 10 tex x 2 (Nm 100/2), while the count of SIRO yarn is 10 tex x 2 (Nm 100/2). Fabrics will be knitted in different constructions. PA multifilament yarns will be added into knitted fabrics for making hosiery.Samples of finished leather (cow and calfskin leather) for inner parts of the upper of working and protective footwear will be prepared. They will be treated with different types of tanning agents. Three samples will be prepared, nature crust, post-tanned crust with the simultaneous treatment with antimicrobial agents and dyed crust with post-tanning and antimicrobial treatment. For all samples of knitted fabrics and leathers objective parameters of thermophysiological comfort will be determined. Antimicrobial activity of all samples of knitted fabric (antimicrobially treated) and leather will be determined according 3 types of bacteria (A. baumannii, S. aureus and E. coli) that can be found in the normal physiological skin flora of man which can be opportunistic pathogens. Thermophysiological comfort of hosiery and working and protective footwear manufactured at local factories will be determined on thermal foot. The comet test will be performed for a number of leather samples (chrome- and synthetic tanned).  ]]></summary_en></project><project>
<id>4158</id><title_hr><![CDATA[Lipidi hrane, spol i dob u patogenezi metaboličkog sindroma]]></title_hr><title_en><![CDATA[Dietary lipids, sex and age in pathogenesis of metabolic syndrome ]]></title_en><user_id>12663</user_id><user_firstLast_name>Kristina Starčević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-3163</code><acronim><![CDATA[DietMetSyn]]></acronim><duration>01.12.2017 - 30.11.2021</duration><status>Završio</status><financ_value>132.284,82 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Veterinarska medicina, </scie_field_hr><scie_field_en>Veterinary medicine, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Veterinarski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Veterinary Medicine]]></institution_en><team_members_id>5392, 12628, 1195, 12946, 11258, 13016, 4742, 19404, 13262, 19649, 19446, 19753, 19807, 19676, 19715, 20212, 12528, 19731, 25364, 857312, </team_members_id><team_members_names><![CDATA[Tomislav Mašek, Luka Krstulović, Ivan - Conrado Šoštarić - Zuckermann, Diana Brozić, Silvijo Vince, Maja Maurić, Krešimir Severin, Nada Kučer, Petar Džaja, Gordana Nedeljković, Dražen Vnuk, Andrija Musulin, Jasna Dogan, Žarko Ćirić, Ivana Jarak, Snježana Dragojević, Miroslav Bajić, Rui  de Albuquerque Carvalho, Petra Roškarić, Valentina Percan, ]]></team_members_names><keywords_hr><![CDATA[Lipidi, metabolički sindrom, hrana, miRNA, kronična upala, rezistencija na inzulin]]></keywords_hr><keywords_en><![CDATA[Lipids, metabolic syndrome, food, miRNA, cronic inflammation, insulin resistence]]></keywords_en><summary_hr><![CDATA[Poremećaj metabolizma lipida ključna je komponenta u razvoju metaboličkog sindroma pa je i prevalencija metaboličkog sindroma povezana sa stupnjem pretilosti. Stoga, promjene u sastavu hrane mogu biti važna strategija za prevenciju metaboličkog sindroma i posljedičnih bolesti.Pretilost nastaje tijekom dugotrajne pozitivne energetske ravnoteže koja potiče proupalni odgovor. To uzrokuje kroničnu upalu i pojačani dotok lipida iz masnog tkiva u jetru, mišićno tkivo i gušteraču što rezultira s glukotoksičnosti i lipotoksičnosti. Kronična upala i rezistencija na inzulin danas su prepoznati kao bitni čimbenici kod mnogih bolesti kao što su dijabetes tipa 2, kardiovaskularne bolesti, Alzheimerove bolesti i tumora.Za postizanje ciljeva projekta istražit ćemo nekoliko interakcija važnih za patogenezu metaboličkog sindroma: A) utjecaj n3/n6 omjera lipida hrane i dodavanja DHA kao prevencije metaboličkog sindroma, B) utjecaj n3/n6 omjera lipida hrane i dodavanja DHA kao moguće terapije metaboličkog sindroma, C) prijenos sklonosti razvitku metaboličkog sindroma i prekomjerne tjelesne mase s roditelja na potomstvo kao i utjecaj prehrane potomstva na težinu poremetnji prije i nakon spolne zrelosti, D) interakciju između dobi i metaboličkog sindroma i E) metabolizam lipida u tumorskom tkivu i tumorske markere lipidnog porijekla kao moguću vezu između pretilosti, metaboličkog sindroma, kronične upale i tumora.Naposlijetku, podaci iz cijelog projekta rezultirat će integracijom stečenih znanja iz svih pokusa i boljem razumijevanju složenosti patogeneze metaboličkog sindroma. Integrativni pristup omogućit će nove pristupe prevenciji i liječenju metaboličkog sindroma putem modifikacije prehrane kao i bolje razumijevanje veze između kronične upale izazvane pretilošću i tumora.]]></summary_hr><summary_en><![CDATA[Dysfunction of lipid metabolism is a key component in the development of metabolic syndrome and the prevalence of metabolic syndrome is strongly associated with the severity of obesity. Therefore, dietary intervention could be important strategy for the prevention of metabolic syndrome and associated diseases.Obesity arises from a sustained positive energy balance which triggers a pro-inflammatory response. These disturbances culminate in impaired insulin signaling, dysregulated glucose homeostasis and consequent development of insulin resistance. Chronic inflammation and insulin resistance are now recognized as contributing factors to many modern diseases such as insulin non dependent diabetes mellitus, cardiovascular diseases, Alzheimer disease and cancer. To achieve project objectives we will investigate several interactions that take place in metabolic syndrome pathogenesis: A) Influence of dietary n6/n3 ratio and DHA as a preventive mechanism on the severity of metabolic syndrome, B) Influence of dietary n6/n3 ratio and DHA on therapy of induced metabolic syndrome, C) Parental transmission of predisposition to obesity-related disorders to their offspring and influence of offspring diet on severity of metabolic disorders before and after sexual maturity, D) Interaction between age and metabolic syndrome and E) Cancer lipid metabolism and cancer markers of lipid origin as well as possible link between obesity, metabolic syndrome, low grade chronic inflammation and cancer.Finally, data from the whole project will result in the integration of gained knowledge from all experiments and in better understanding of complex pathogenesis of metabolic syndrome. Integrative approach will allow us to suggest new approaches to dietary prevention and therapy of metabolic syndrome and to better understand underlying link between obesity related chronic inflammation and cancer.]]></summary_en></project><project>
<id>4165</id><title_hr><![CDATA[Prevalencija i molekularna epidemiologija emergentnih i re-emergentnih neuroinvazivnih arbovirusnih infekcija na području Hrvatske]]></title_hr><title_en><![CDATA[Prevalence and molecular epidemiology of emerging and re-emerging neuroinvasive arboviral infections in Croatia]]></title_en><user_id>19086</user_id><user_firstLast_name>Tatjana Vilibić Čavlek</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-7456</code><acronim><![CDATA[CRONEUROARBO]]></acronim><duration>01.03.2017 - 28.02.2021</duration><status>Završio</status><financ_value>128.526,11 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo, Prirodne znanosti, </scie_area_hr><scie_area_en>Biomedicine and health sciences, Natural sciences, </scie_area_en><scie_field_hr>Javno zdravstvo i zdravstvena zaštita, Biologija, Kliničke medicinske znanosti, Veterinarska medicina, </scie_field_hr><scie_field_en>Public health and health services, Biology, Clinical sciences, Veterinary medicine, </scie_field_en><institution_hr><![CDATA[Hrvatski zavod za javno zdravstvo, Zagreb]]></institution_hr><institution_en><![CDATA[Croatian National Institute of Public Health, Zagreb]]></institution_en><team_members_id>19507, 2676, 19827, 19511, 19394, 19533, 4211, 19546, 4371, 19530, 7738, 3103, 2964, 19517, 19803, 2546, 2599, 19651, 409, 25186, 25187, 21453, 25253, 3892, 25260, </team_members_id><team_members_names><![CDATA[Ljiljana Perić, Nenad Pandak, Tanja Potočnik-Hunjadi, Andrea Babić-Erceg, Irena Tabain, Mario  Sviben, Maja Bogdanić, Tatjana Avšič-Županc, Ljubo Barbić, Vladimir Stevanović, Josip Madić, Vladimir Savić, Andreja Jungić, Ana Klobučar, Krunoslav Capak, Lorena Jemeršić, Jelena Prpić, Bernard Kaić, Branko Kolarić, Elizabeta Dvorski, Marina Baličević, Marija Santini, Dario  Sabadi, Marko Vucelja, Marko Boljfetić Boljfetić, ]]></team_members_names><keywords_hr><![CDATA[Arbovirusi, neuroinvazivne infekcije, prevalencija, molekularna epidemiologija, Hrvatska]]></keywords_hr><keywords_en><![CDATA[Arboviruses, neuroinvasive diseases, prevalence, molecular epidemiology, Croatia]]></keywords_en><summary_hr><![CDATA[Emergentne arbovirusne infekcije značajan su uzrok morbiditeta i mortaliteta. Iako većina infekcija prolazi asimptomatski, u nekih se bolesnika arbovirusne infekcije očituju teškom kliničkom slikom neuroinvazivne bolesti. Dok je uloga virusa krpeljnog encefalitisa (KEV), virusa Zapadnog Nila (VZN) i Toscana virusa (TOSV) u etiologiji neuroinvazivnih bolesti poznata, uloga Usutu virusa (USUV), Zika virusa (ZIKV), dengue virusa (DENV) i chikungunya virusa (CHIKV) još uvijek nije dovoljno istražena. U Hrvatskoj se godišnje prijavljuje prosječno 200 slučajeva seroznih meningitisa/encefalitisa od kojih u 80-90% nije dokazana etiologija. To se posebno odnosi na emergentne viruse koji nisu uključeni u rutinsko dijagnostičko testiranje. Isto tako, nisu dovoljno istražene kliničke i epidemiološke značajke arbovirusnih infekcija. Određivanje seroprevalencije u ljudi i životinja te prisutnosti virusa u vektorima vrlo su dobri pokazatelj cirkulacije i proširenosti arbovirusnih infekcija na nekom području. Ovo interdisciplinarno (&#39;&#39;Jedno zdravlje&#39;&#39;) istraživanje uključit će bolesnike s kliničkom slikom neuroinvazivne bolesti s područja kontinentalne Hrvatske, oboljele u sezoni prijenosa arbovirusa. Istražit će se učestalost neuroinvazivnih arbovirusa: KEV, VZN, USUV, TOSV, DEVN, CHIKV, ZIKV određivanjem virusne RNA u likvoru/urinu te protutijela u serumu, definirati kliničke i molekularno epidemiološke značajke arbovirusnih infekcija. Nadalje, definirat će se rasprostranjenost arbovirusnih infekcija određivanjem seroprevalencije u asimptomatskih osoba i sentinel životinja (konji, domaća perad) te prisutnost virusa u vektorima (komaraci/krpelji).Moguća detekcija novih arbovirusa omogućit će razjašnjenje etiologije u bolesnika oboljelih od neuroinvazivnih bolesti. Definiranje molekularno-epidemioloških značajki doprinijet će boljem razumijevanju epidemiologije arbovirusnih infekcija kao i unaprjeđenju ciljanih javnozdravstvenih mjera prevencije i suzbijanja arbovirusnih bolesti. ]]></summary_hr><summary_en><![CDATA[Emerging and re-emerging arboviral diseases are important cause of morbidity and mortality. Although majority infections are asymptomatic, some patients develop a severe neuroinvasive disease. While the role of the tick-borne encephalitis virus (TBEV), West Nile virus (WNV) and Toscana virus (TOSV) in the etiology of neuroinvasive diseases is well-known, the role of Usutu virus (USUV), Zika virus (ZIKV), dengue virus (DENV) and chikungunya virus (CHIKV) is rather unknown. About 200 cases of aseptic meningitis/encephalitis are reported annually in Croatia, of which in 80-90% etiology has remained unknown. This is particularly important for emerging viruses which are not included in the routine diagnostic testing. Moreover, the clinical and epidemiological characteristics of arboviral infections are not fully investigated. Seroprevalence determination in humans and animals, as well as detection of viruses in vectors are good indicators of circulation and geographical distribution of arboviruses in a certain area. This prospective interdisciplinary (&#39;&#39;One health&#39;&#39;) study will include patients with clinical symptoms of neuroinvasive disease from the continental Croatian regions who developed symptoms during the arbovirus transmission season. The prevalence of neuroinvasive arboviruses (TBEV, WNV, USUV, TOSV, DENV, CHIKV, ZIKV) will be determined by detection of viral RNA in the cerebrospinal fluid/urine and detection of antibodies in serum. Clinical characteristics and molecular epidemiology will be defined. Additionally, the geographical distribution of arboviral infections will be analyzed by determination of seroprevalence in asymptomatic persons and sentinel animals as well as detection of viruses in vectors.Possible detection of new arboviruses will clarify the etiology in patients with neuroinvasive diseases. Molecular epidemiology data will provide better understanding of epidemiology of arboviral infections as well as improving the public health measures.]]></summary_en></project><project>
<id>4167</id><title_hr><![CDATA[Interakcija renin-angiotenzinskog i adrenergičkog sustava u aktivaciji endotela uzrokovanoj oksidativnim stresom]]></title_hr><title_en><![CDATA[Interaction of Renin-Angiotensin and Adrenergic System in Oxidative Stress Induced Endothelial Activation]]></title_en><user_id>487</user_id><user_firstLast_name>Ana Stupin (rođ. Čavka)</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-8744</code><acronim><![CDATA[RAS-AdrenOX]]></acronim><duration>03.04.2017 - 02.10.2021</duration><status>Završio</status><financ_value>132.682,33 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Medicinski fakultet Osijek]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Medicine]]></institution_en><team_members_id>488, 548, 477, 594, 482, 19414, 20340, 722, 732, 6307, </team_members_id><team_members_names><![CDATA[Martina Mihalj, IVANA JUKIĆ (rođ.GRIZELJ), Ines Drenjančević, Anita Ćosić, Zrinka Mihaljević, Marko Stupin, Ines Mrakovčić-Šutić, Kristina Selthofer-Relatić, Aleksandar Kibel, Vatroslav Šerić, ]]></team_members_names><keywords_hr><![CDATA[renin-angiotenzinski sustav, adrenergički sustav, oksidativni stres, mikrocirkulacija, leukociti, upala]]></keywords_hr><keywords_en><![CDATA[Renin-Angiotensin System, Adrenergic System, Oxidative Stress, Microcirulation, Leukocyte, Inflammation ]]></keywords_en><summary_hr><![CDATA[Rezultati nedavnih studija pokazali su kako inhibicija renin-angiotenzinskog sustava (RAS) i niska koncentracija angiotenzina II (ANG II) potaknuta visokim unosom kuhinjske soli uzrokuje oštećenje endotelne funkcije i mikrovaskularne reaktivnosti u zdravih pojedinaca (bez promjena arterijskoga tlaka) vjerojatno povišenjem razine oksidativnog stresa. Ipak, još uvijek nije istraženo na koji način inhibicija RAS-a djeluje na aktivnost adrenergičkog sustava, te mogu li te promjene doprinijeti oštećenju endotelne funkcije povišenjem oksidativnog stresa. Također, smatra se kako inhibicija RAS-a, povećanim unosom kuhinjske soli, može djelovati kao okidač za ravoj upalnog procesa i endotelno-leukocitnu aktivaciju koji mogu doprinijeti oštećenju vaskularne funkcije. Hipoteza ovog projektnog prijedloga je postojanje interakcije između niske koncentracije ANG II (zbog visokog unosa kuhinjske soli) i aktivnosti simpatikusa u povišenju razine oksidativnog stresa s posljedičnim oštećenjem endotelne funkcije, aktivacije leukocita te smanjenje mikrovaskularne reaktivnosti in vivo. Istraživanje će se provoditi na mladim zdravim pojedincima oba spola. Navedenu hipotezu istražit ćemo u dva glavna cilja: Cilj 1 – sistemskim in vivo pokusima razlučiti učinak inhibicije RAS-a (kratkotrajnom dijetom s visokim udjelom soli) na mikrovaskularnu reaktivnost i aktivnost simpatikusa, s naglaskom na povišenu razinu oksidativnog stresa u navedenim promjenama, u zdravih mladih pojedinaca oba spola; i Cilj 2 – odrediti učinak inhibicije RAS-a na interakciju između endotelnih stanica i leukocita, kao i na distribuciju progenitornih endotelnih stanica u krvi u zdravih mladih pojedinaca oba spola. Rezultati ovog istraživanja mogli bi pružiti dokaz kako oštećenje mehanizama normalne vaskularne relaksacije i endotelno-leukocitne aktivacije imaju presudnu ulogu u razvoju kardiovaskularnih bolesti, posebice onih u kojima je RAS inhibiran a aktivnost adrenergičkog sustava promijenjena. ]]></summary_hr><summary_en><![CDATA[Recent studies have shown that inhibition of renin-angiotensin system (RAS) and low angiotensin II (ANG II) level induced by high salt (HS) intake affect endothelial function and microvascular reactivity in healthy individuals (in the absence of increased blood pressure) probably by increasing oxidative stress level. However, does RAS inhibition affect adrenergic system in healthy individuals, and whether this changes can contribute to increased oxidative stress level in developing endothelial dysfunction remains to be investigated. It has been suggested that RAS inhibition due to HS intake may acts as a trigger for the inflammatory process inception and endothelial-leukocyte activation which contributes to the impairment of vascular function. In this project we will test the hypothesis that there is an interaction of decreased levels of ANG II (due to HS intake) and sympathetic activity leading to endothelial and leukocyte activation by increasing oxidative stress, and further, impaired microvascular reactivity in humans in vivo. Study will be performed in young healthy human subjects of both sexes. This hypothesis will be investigated in two general aims: Aim 1 - to elucidate the effect of RAS inhibition (with short-term HS diet) on microvascular reactivity and sympathetic activity (with emphasis on increased oxidative stress in observed changes) in young healthy subjects of both sexes, systemically in vivo; and in the Aim 2 - to determine the effect of RAS inhibition on endothelial cells and leukocytes interactions, as well as on endothelial progenitor cells blood distribution in young healthy subjects of both sexes. The results may provide evidence that the impairment of normal vascular relaxation mechanisms and endothelial-leukocyte activation could play crucial role in increased risk of cardiovascular disease development, particularly in condition when RAS is inhibited and adrenergic system activity changed. ]]></summary_en></project><project>
<id>4179</id><title_hr><![CDATA[NOVI I ZAPOSTAVLJENI VIRUSNI UZROČNICI INFEKCIJA DIŠNOG SUSTAVA U VULNERABILNIM SKUPINAMA BOLESNIKA]]></title_hr><title_en><![CDATA[NEW AND NEGLECTED RESPIRATORY VIRUSES IN VULNERABLE GROUPS OF PATIENTS]]></title_en><user_id>2562</user_id><user_firstLast_name>Sunčanica Ljubin Sternak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-7556</code><acronim><![CDATA[RESPIVIRUS]]></acronim><duration>01.03.2017 - 31.08.2021</duration><status>Završio</status><financ_value>125.569,05 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Javno zdravstvo i zdravstvena zaštita, Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Public health and health services, Clinical sciences, </scie_field_en><institution_hr><![CDATA[Nastavni zavod za javno zdravstvo Dr. Andrija Štampar, Zagreb]]></institution_hr><institution_en><![CDATA[Andrija Stampar Teaching Institute of Public Health, Zagreb]]></institution_en><team_members_id>19327, 19647, 12641, 19359, 409, 19323, 3210, 19394, 19674, 19567, 19462, 19693, 25051, </team_members_id><team_members_names><![CDATA[Gordana Mlinarić-Galinović, Ann Regina Falsey, Jasmina Vraneš, Amarela Lukić-Grlić, Branko Kolarić, Irena Ivković-Jureković, Rok Čivljak, Irena Tabain, Ivana Lukšić, Zvonimir Barišić, Tatjana Marijan, Tatjana Tot, Maja Mijač, ]]></team_members_names><keywords_hr><![CDATA[respiratorne infekcije, prevencija rezistencije, djeca, stariji bolesnici,  multiplex PCR, metapneumovirus, bokavirus, parehovirus]]></keywords_hr><keywords_en><![CDATA[respiratry infections,  prevention of resistance, children, elderly, multiplex PCR, metapenumovirus, bocavirus, parechovirus]]></keywords_en><summary_hr><![CDATA[Akutne infekcije dišnog sustava (ARI) najčešće su infekcije ljudi svih dobnih skupina, a kako su većinom uzrokovane virusima, najčešći su razlog nepotrebnog propisivanja antibiotika – jednog od vodećih javno zdravstvenih problema. ARI su osobito značajan uzrok pobolijevanja i smrtnosti  vulnerabilnih skupina bolesnika kao što su djeca kod kojih na ishod bolesti utječe mali promjer dišnih puteva i nezrelost imunog sustava i osobe starije dobi koje su opterećene kroničnim bolestima i procesom imunosenscencije. Virusne ARI od bakterioloških nije moguće razlučiti bez specifične virološke dijagnostike. Razvoj pak metoda laboratorijske dijagnostike doveo je do otkrića novih virusnih uzročnika ARI (metapneumovirus, bokavirus, novi koronavirusi) ali i omogućio detekciju mnogih do sada teško dokazivih i zbog toga zapostavljenih uzročnika (respiratorni enterovirusi, parehovirusi, virus parainfluence tip 4). Nadalje, zbog osjetljivosti molekularnih metoda dijagnostike, višestruka detekcija uzročnika u istom uzorku je sve češća, a pitanje prepoznavanja pravog patogena tijekom koinfekcije postaje imperativ. Cilj ovog projektnog prijedloga je utvrditi epidemiološke karakteristike i kliničko značenje 15 virusnih uzročnika ARI (virusi influence tipovi A i B, parainfluence tipovi 1-4, respiratorni sincicijski virus A i B, metapneumovirus, adenovirus, koronavirusi 229E/NL63 i OC43/HKU1, enterovirus, rinovirus i parehovirus) s posebnim osvrtom na novootkrivene i zapostavljene virusne uzročnike, u vulnerabilnim skupinama bolesnika multipleks PCR metodom. Kao doprinos prepoznavanju pravog respiratornog patogena u  infekcijama s više virusnih uzročnika, odrediti će se količina virusa u respiratornom sekretu. Krajnji doprinos ovog projekta je poduprijeti javno zdravstvene mjere koje se poduzimaju u svrhu promjene uobičajene prakse rutinskog propisivanja antibiotika za liječenje ARI u korist dijagnostike virusnih infekcija, a s dugoročnim ciljem prevencije bakterijske rezistencije.]]></summary_hr><summary_en><![CDATA[Acute respiratory infections (ARIs) are the most common infections in humans of all ages, and although viruses cause the majority of ARIs, they are the main reason for overuse of the antibiotics that represent one of the main public health issues today. ARI are particularly significant cause of morbidity and mortality of vulnerable patient groups such as children in whom the outcome of the disease affects the small size of their airways and the immaturity of the immune system, and elderly people who are burdened with chronic diseases and imunosenescence. Without specific viral diagnostics, it is not possible to distinguish between viral and bacterial ARI. Rapid advance of laboratory methods has led to the discovery of new viruses (metapneumovirus, bocavirus), and has enabled diagnosis of laboratory demanding and thus neglected viruses (enterovirus, parechovirus, parainfluenza type 4). Due to high sensitivity of molecular methods, simultaneous detection of multiple pathogens is more common, and question of recognizing the true pathogen in co-infection becomes imperative. The aim of this project is to determine the epidemiological characteristics and clinical significance of 15 viral pathogens causative agents of ARI (influenza A and B, parainfluenza 1-4, respiratory syncytial virus A and B, metapneumovirus, adenovirus, coronaviruses 229E/NL63 and OC43/HKU1, enterovirus, rhinovirus and parechovirus) with special emphasis on newly discovered and neglected pathogens, in vulnerable patient groups, using multiplex PCR method. As a contribution to the recognition the true respiratory pathogen in multiple viruses’ coinfection, the amount of viruses in respiratory secretions will be determined. The ultimate goal of this project is to contribute to the public health efforts to change the medical doctor’s routine decisions against prescription of antibiotics for ARIs in favor of viral diagnosing, which would contribute to the prevention of bacterial resistance.]]></summary_en></project><project>
<id>4194</id><title_hr><![CDATA[Novi oralni antikoagulansi: povezanost koncentracije lijeka i antikoagulantnog učinka]]></title_hr><title_en><![CDATA[New oral anticoagulants: relationship between drug concentration and anticoagulant effect  ]]></title_en><user_id>19440</user_id><user_firstLast_name>Sandra Margetić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-8208</code><acronim><![CDATA[LAB-NOAC]]></acronim><duration>01.04.2017 - 30.09.2022</duration><status>Završio</status><financ_value>79.633,69 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Javno zdravstvo i zdravstvena zaštita, Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Public health and health services, Clinical sciences, </scie_field_en><institution_hr><![CDATA[Klinički bolnički centar "Sestre Milosrdnice", Zagreb]]></institution_hr><institution_en><![CDATA[Clinical Hospital Center "Sestre Milosrdnice", Zagreb]]></institution_en><team_members_id>1176, 7013, 4780, 6134, 19963, 19941, 19931, 5168, 25110, 19873, 28925, </team_members_id><team_members_names><![CDATA[Arijana Lovrenčić-Huzjan, Vanja Bašić Kes, Diana Delić-Brkljačić, Ivana Ćelap, Ana Bronić, Ivana Vuga Vuga, Nikola Pavlović, Silvio Bašić, Marija Brčić, Sandra Šupraha Goreta, Esmat Elabjer, ]]></team_members_names><keywords_hr><![CDATA[novi antikoagulantni lijekovi, izravni inhibitori trombina, izravni inhibitori FXa, laboratorijske pretrage, koncentracija lijeka]]></keywords_hr><keywords_en><![CDATA[new anticoagulant drugs, direct thrombin inhibitors, direct inhibitors of FXa, laboratory assays, drug concentration  ]]></keywords_en><summary_hr><![CDATA[Novi oralni antikoagulansi (NOAK), uključujući izravni inhibitor trombina (dabigatran) i izravne inhibitore faktora Xa (rivaroksaban i apiksaban), posljednjih su godina uvedeni u prevenciju i liječenje tromboembolijskih bolesti. Iako se doziranje NOAK lijekova ne temelji na rezultatima laboratorijskih pretraga, pa rutinsko praćenje terapije nije potrebno, prva klinička iskustva nametnula su brojne rasprave o potrebi procjene antikoagulantnog učinka NOAC lijekova u određenim kliničkim situacijama. Stoga su osnovni ciljevi predloženog projekta istraživanje povezanosti koncentracije lijeka i učinka liječenja i definiranje kliničkih stanja u kojima bi bilo neophodno ili korisno određivati koncentraciju lijeka. U istraživanje planiramo uključiti bolesnike liječene NOAK  lijekovima u svim odobrenim kliničkim indikacijama, uključujući prevenciju i liječenje venske tromboembolije, te prevenciju moždanog udara i sistemne embolije u bolesnika s nevalvularnom fibrilacijom atrija. Metode istraživanja uključiti će specifične kvantitativne koagulacijske pretrage određivanja koncentracije lijeka: razrijeđeno trombinsko vrijeme za lijek dabigratan i aktivnost FXa za lijekove rivaroxaban i apixaban, uz istodobnu primjenu dvaju komercijalnih kvantitativnih testova za svaki pojedini lijek. Važnost rezultata predloženog istraživanja je u ispitivanju i usporedbi kvantitativnih metoda određivanja koncentracije NOAK lijekova te u definiranju kliničkih situacija u kojih bi se određivanje koncentracije lijeka pokazalo klinički značajnim. Rezultati istraživanja omogućili bi i osnovu za kreiranje smjernica u implementaciji kvantitativnih koagulacijskih pretraga određivanja koncentracije NOAK-a na nacionalnoj razini. Očekujemo da će dobiveni rezultati značajno unaprijediti spoznaje o liječenju bolesnika NOAC lijekovima, razumijevanje rezultata kvantitativnih metoda određivanja koncentracije NOAK lijekova te primjenu standardiziranih protokola u praćenju liječenja i u daljnjim istraživanjima. ]]></summary_hr><summary_en><![CDATA[New oral anticoagulants (NOACs), including direct thrombin inhibitor (dabigratan)and direct inhibitor of FXa (rivaroxaban and apiksaban), have recently been introduced in the prevention and treatment of thromboembolic diseases. Although dosage of NOACs is not based on the laboratory test results, thus making routine therapy monitoring not necessary, current clinical experience has imposed numerous discussions about the need of measuring their anticoagulant effect  in certain clinical situations. Therefore, the main goals of the proposed project are to study the relationship between drug concentration and effect of treatment and to highlight and define clinical conditions in which it would be required or useful to determine drug concentration. We plan to involve patients treated with NOACs in all approved clinical indications, including prevention and treatment of venous thromboembolism and prevention of stroke and systemic embolism in patients with non-valvular atrial fibrillation. Research methods will include specific quantitative coagulation assays for drug concentration determination: diluted thrombin time for dabigatran and anti FXa activity for rivaroxaban and apixaban, with simultaneous application of two commercial quantitative assays for each NOAC. The importance of the results is to evaluate and compare quantitative methods for determining concentration of NOACs and to define clinical situations in which determination of drug concentration would show clinical significance. The results would enable a basis for creation of guidelines for the implementation of quantitative coagulation assays in defined clinical situations at national level. We expect that the results will significantly improve the knowledge related to the treatment of patients with NOACs, understanding the results of specific quantitative methods for determining drug concentrations, as well as implementation of standardized protocols in patient treatment and further research.]]></summary_en></project><project>
<id>4198</id><title_hr><![CDATA[Genomički aspekti brze evolucije primorske gušterice (Podarcis sicula)]]></title_hr><title_en><![CDATA[Genomic aspects of rapid evolution of Italian wall lizard (Podarcis sicula)]]></title_en><user_id>19008</user_id><user_firstLast_name>Anamaria Štambuk Štambuk</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-9177</code><acronim><![CDATA[GENRALIZ]]></acronim><duration>01.03.2017 - 31.08.2021</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>13161, 19725, 19930, 19471, 19735, 19712, 19714, 19995, 20103, 25018, 855618, 24034, </team_members_id><team_members_names><![CDATA[Duje Lisičić, Ivan Cizelj, Zoran Tadić, Dorotea Polović, Maja Šrut, Anthony Herrel, Jessica Stapley, Stuart Dennis, Miguel  Baltazar Soares, Iva Sabolić, Oscar Mira Perez, Marko Glogoški, ]]></team_members_names><keywords_hr><![CDATA[adaptivna evolucija, populacijska genomika, selekcija, evolucijska ekologija, fenotipska evolucija, Lacertidae, otoci, morfologija guštera, prehrana]]></keywords_hr><keywords_en><![CDATA[adaptive evolution, population genomics, selection, evolutionary ecology, phenotypic divergence, Lacertidae, islands, lizard morphology, diet]]></keywords_en><summary_hr><![CDATA[Sposobnost vrsta da nastanjuju nove okoliše ovisi u najvećoj mjeri o sposobnosti jedinki da se prilagode drugačijim ekološkim uvjetima. Razumijevanje mikroevolucijskih procesa koji određuju brzu adaptivnu evoluciju, kao i načina na koji selekcija oblikuje fenotipsku divergenciju u prirodnim populacijama i dalje je jedan od glavnih ciljeva evolucijske biologije. Ovaj projekt implementira dosadašnja saznanja o povijesti kolonizacije i ekološki uvjetovanoj fenotipskoj divergenciji populacija gušterice Podarcis sicula na otocima Lastovskog arhipelaga (Jadran) u istraživanje evolucijskih procesa koji uvjetuju brze fenotipske promjene u populacijama izloženim novim okolišnim uvjetima.  Ukratko, 1971. godine proveden je pokus u kojem je pet parova  gušterica P. sicula premješteno s njihovog nativnog otoka Pod Kopište na susjedni otok Pod Mrčaru. 35 godina nakon introdukcije za populaciju gušterica u novom okolišu utvrđena je nevjerojatna fenotipska divergencija u morfologiji i ekologiji, uzrokovana prijelazom s insektivorne na omnivornu prehranu. Ciljevi ovog projekta su: odrediti da li su te fenotipske promjene posljedica genetičkih promjena ili fenotipske plastičnosti, te saznati, proučavanjem dodatnih prirodnih populacija, kako fenotipska divergencija i učinak uskog grla utječu na genomičku divergenciju populacija gušterica P. sicula. Eksperimentalni i analitički okvir projekta, koji se bazira na pokusima križanja, pokusima „zajedničkog okoliša“ te populacijskoj genomici, omogućit će nam da testiramo da li 1) brzo evolvirajuća adaptivna fenotipska obilježja koja su omogućila prijelaz u prehrani gušterica s otoka Pod Mrčaru imaju genetičku osnovu, te da li su 2) jaka selekcija i učinak uskog grla  ostavili jasan otisak na genomičku divergenciju između populacija.]]></summary_hr><summary_en><![CDATA[The successful establishment of a species in novel environment depends on the capacity of individuals to cope with the novel conditions. Understanding the microevolutionary processes underlying rapid adaptive evolution and the way selection shapes phenotypic divergence in natural populations remains one of the major goals of evolutionary biology. In the proposed project we leverage the relatively well known colonisation history, and knowledge on ecologically induced phenotypic divergence of populations of the lizard Podarcis sicula that inhabit islands of the Lastovo archipelago (Adriatic) to study the evolutionary events driving rapid phenotypic shifts in populations encountering novel environments. Briefly, in 1971 a transplant experiment was conducted in which five pairs of P. sicula were introduced from their native island Pod Kopište onto a nearby islet, Pod Mrčaru. In 35 years since their introduction those populations exhibited spectacular phenotypic divergence in morphology and ecology, linked to a dietary shift from an insectivorous to an omnivorous diet. This project aims to identify if this phenotypic shift is due to genetic changes or phenotypic plasticity, and to investigate additional populations to understand how rapid phenotypic divergence and population bottlenecks influence genomic divergence amongst P. sicula populations. The experimental and analytical framework based on common garden experiments and population genomics will enable us to test whether 1) the rapidly evolved and adaptive phenotypic traits that facilitate a dietary shift in lizards from Pod Mrčaru have a genetic basis, and 2) if strong selection and population bottlenecks left distinct signatures of genomic divergence between populations.]]></summary_en></project><project>
<id>4202</id><title_hr><![CDATA[NUMERIČKI EFIKASNI RAČUNALNI ALGORITMI ZA UGRADBENE MULTI-FIZIKALNE SUSTAVE U VEKTORSKIM PROSTORIMA I NA MNOGOSTRUKOSTIMA]]></title_hr><title_en><![CDATA[NUMERICALLY EFFICIENT COMPUTATIONAL ALGORITHMS FOR EMBEDDED MULTI-PHYSICAL SYSTEMS IN VECTOR SPACES AND MANIFOLDS]]></title_en><user_id>7734</user_id><user_firstLast_name>Zdravko  Terze</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-6696</code><acronim><![CDATA[NUMECA4EMBEDDED]]></acronim><duration>20.03.2017 - 19.08.2021</duration><status>Završio</status><financ_value>126.119,85 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Zrakoplovstvo, raketna i svemirska tehnika, Strojarstvo, </scie_field_hr><scie_field_en>Aerospace, missile and space engineering, Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>20301, 20336, 19369, 19367, 20025, 20027, 20065, 20307, 23235, 28668, </team_members_id><team_members_names><![CDATA[Milan Vrdoljak, Dubravko Matijašević, Dario Zlatar, Viktor Pandža, Andreas Mueller, Carlo Luigi Bottasso, Arnold Martin, Pierangelo Masarati, Marijan Andrić, Marko Kasalo, ]]></team_members_names><keywords_hr><![CDATA[geometrijska integracija, računanje u stvarnom vremenu, ugradbeni sustav, redukcija modela, sustav više tijela, interakcija fluida i strukture]]></keywords_hr><keywords_en><![CDATA[geometric integration, real-time simulation, embedded system, model reduction, multibody system, fluid-structure interaction]]></keywords_en><summary_hr><![CDATA[Razvoj numerički efikasnih simulacijskih modela za rad u stvarnom vremenu predmet je velikog interesa istraživača tijekom poslijednjih godina. S obzirom na stalni razvoj suvremenih tehnologija temeljenim na primjeni sve složenijih ugradbenih sustava, povećale su se i potrebe za simulacijskim modelima takvih složenih objekata, pri čemu se dinamika različitih multi-fizikalnih modela simulira unutar zajedničkog algoritma u stvarnom vremenu. Za razliku od jednostavnijih mehaničkih sustava, čije se procesiranje u stvarnom vremenu može postići konvencionalnim računalnim metodama, spregnuti multi-fizikalni sustavi zahtjevaju napredne algoritme koji su predmet intenzivnih istraživanja.Tijekom ovog projekta, uz standardne računalne formulacije u vektorskim prostorima, istražit će se i geometrijski numerički algoritmi na mnogostrukostima i Lievim grupama u svrhu razvoja numerički efikasnih simulacijskih procedura za multi-fizikalne ugradbene sustave. Posebna zadaća će se posvetiti ciljem vođenim zadaćama redukcije spregnutih modela, geometrijskim integracijskim algoritmima koji održavaju diferencijalno-geometrijsku strukturu dinamike spregnutih sustava, efikasne implementacije na specifičnom hardveru. Kada god je to opravdano, provest će se usporedba novorazvijenih geometrijskih numeričkih procedura s konvencionalnim formulacijama u vektorskim prostorima, a posebno u području redukcije multi-fizikalnih modela i optimiranih integracijskih procedura. Nakon odabira najprikladnijih algoritama, projektom će se istražiti prikladni hardver za ciljem vođene platformske (‘on-line’) računalne simulacije dinamike ugradbenih sustava. U toj fazi istraživanja, odabrat će se prikladna programska paradigma za novorazvijene algoritme i numerički eksperimenti. Poslijednja faza projekta obuhvatit će dizajn eksperimentalnih postava za odabrane multi-fizikalne ugradbene sustave s ciljem validacije numeričke efikasnosti, upravljivosti i stabilnosti novorazvijenih računalnih algoritama i procedura.]]></summary_hr><summary_en><![CDATA[Development of the numerically efficient simulation models capable of running in real-time has been a particular focus for researchers and industrial developers during the last decade. With the constant developments in the field of embedded systems, the demand for real-time simulation models of complex mechanical systems, where dynamics of different multi-physical models needs to be co-simulated within the same framework, became even larger. While conventional modelling techniques are suitable for simulating simpler tasks, coupled mechanical systems require more advanced techniques than those still being used.In this project, geometric numerical algorithms formulated on manifolds and Lie groups, as well as standard vector space formalisms, will be investigated in order to design efficient simulation procedures for multi-physical dynamics of the embedded systems. To this end, special attention will be devoted to the issues such as objective-based model reduction, structure preserving integration schemes, efficient numerical techniques and hardware-oriented code implementation. Whenever justified, novel differential-geometric computational procedures will be numerically tested against the standard vector space formalisms, especially in the context of the multi-physics model reduction and optimized integration schemes. Once the most appropriate computational models and numerical algorithms are selected during off-line simulations of the real-time dynamical processes, the project will focus on investigation of the suitable hardware platforms for the objective-based on-board simulations. This step also includes selection of the programming paradigm for the selected algorithms, as well as numerical tests. Within the last phase, the experimental implementation, comprising building of the testbed for the selected multi-physical embedded systems will be conducted in order to validate the numerical efficiency, controllability, and stability of the overall installations.]]></summary_en></project><project>
<id>4208</id><title_hr><![CDATA[Matične stanice usne šupljine čovjeka za liječenje ishemijske bolesti mozga]]></title_hr><title_en><![CDATA[Stem cells from human oral mucosa for treatment of brain ischemia ]]></title_en><user_id>12653</user_id><user_firstLast_name>Dinko Mitrečić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-9451</code><acronim><![CDATA[ORASTEM]]></acronim><duration>01.10.2017 - 01.11.2022</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>5987, 12687, 5175, 12852, 19754, 4133, 12711, 354, 13179, 19740, 12716, 19613, 12682, 19823, 19657, 7666, 25391, 28671, 858356, </team_members_id><team_members_names><![CDATA[Ivan Alajbeg, Ivan Alić, Ana Andabak Rogulj, Ervina Bilić, Vlaho Brailo, Ivan Domagoj Drmić, Dunja Gorup, Anja Kafka, Katarina Kapuralin, Eva Klarić Sever, Nicaise Charles, Sandu Pitaru, POCHET Roland, Ivana  Rosenzweig, Ivana Savić Pavičin, Zrinka  Tarle, Valentina Hribljan, Denis Jagečić, Paula Stančin, ]]></team_members_names><keywords_hr><![CDATA[moždani udar, matične stanice, sluznica usne šupljine, regenerativna medicina, transkriptom ]]></keywords_hr><keywords_en><![CDATA[stroke, stem cells, oral mucosa, regenerative medicine, transriptome]]></keywords_en><summary_hr><![CDATA[Ishemijska ozljeda mozga je najčešći oblik moždanog udara te predstavlja jedan od najvećih medicinskih problema čovječanstva. U ovom projektu ćemo po prvi put istražiti terapijski potencijal nedavno otkrivenih ektodermalnih matičnih stanica ljudske sluznice usne šupljine (SOS) na modelu ishemije mozga miša. U preliminarnim pokusima smo pokazali da se ove stanice lako dobivaju iz sluznice usne šupljine pacijenta, a zbog svojeg ektodermalnog podrijetla daju živčane i glija stanice. Nakon dobivanja stanica u suradnji sa Stomatološkim fakultetom u Zagrebu, analizirat ćemo njihovo umnažanje, diferencijacijski potencijal i preživljenje tijekom rasta in vitro. Biljege diferencijacije ćemo analizirati RT-PCRom i imunohistokemijom u periodu od 14 dana, a rezultati dobiveni u normalnim uvjetima će se usporediti sa onima u uvjetima hipoksije. Razlike u odgovoru stanica na ishemiju će biti analizirane na razini transkriptoma koja će biti učinjena u suradnji s New York University Abu Dhabi. U idućoj grupi pokusa ćemo transplantirati SOS u mišji model moždanog udara. U dvije vremenske točke, 7 i 30 dana nakon transplantacije ćemo opisati njihovo preživljenje, migraciju i diferencijaciju. Miševi tretirani mišjim živčanim matičnm stanicama, ljudskim stanicama sluznice usne šupljine te netretirani miševi će biti uspoređeni - oslikani na magnetnoj rezonanci (Bruker 7T) i praćeni u nizu testova zdravstvenog statusa. Na taj način ćemo zaključiti o brzini njihovog oporavka. Očekujemo da će matične stanice usne šupljine čovjeka zbog svojeg podrijetla, pozitivnih rezultata na modelima neurodegeneracije i ozljede te naših preliminarnih rezultata pokazati visok potencijal za liječenje ishemijske bolesti mozga. Ukoliko se naša hipoteza potvrdi, ove će stanice zbog svoje dostupnosti, ektodermalnog podrijetla i terapijskog potencijala biti predložene kao stanice prvog izbora u kliničkim pokusima na pacijentima oboljelima od moždanog udara. ]]></summary_hr><summary_en><![CDATA[Ischemic brain damage is the most common form of stroke and represents one of the largest medical problems of the human society. In this project we will, for the first time, analyze therapeutic potential of recently discovered ectodermal stem cells from the oral mucosa (hOMSC) for treatment of brain ischemia. In preliminary experiments we have shown that hOMSC can be easily isolated from the mouth cavity of the patients and because of their origin – they give rise to neurons and glia. After isolation of cells, in collaboration with University of Zagreb School of Dentistry, we will analyze cell proliferation, differentiation potential and survival during cultivation in vitro . We will analyze markers of differentiation by immunhistochemistry and RT PCR in the period of 14 days and results obtained in normal conditions will be compared to in vitro hypoxia. Difference in cell response will be additionally analyzed on the level of transcriptome  which will be performed by New York University Abu Dhabi. In the next group of experiments we will transplant hOMSC in the animal model of stroke. In two time points, 7 and 30 days after transplantation we will describe their survival, migration and differentiation. Mice treated by hOMSC, NSC and untreated group will be tested in standardized tests of mouse Health status and imaged on MRI (Bruker, 7T). This will allow to conclude about histological and functional recovery of tested mice. We expect that, based on their embryonic origin, positive results on animal models of neurodegeneration and nerve damage and our promising preliminary results, hOMSC will exhibit beneficial effects for animals affected by stroke. If our hypothesis will be confirmed, hOMSC will be, because of their easy access, ectodermal origin and therapeutic potential, suggested as the perfect candidate for clinical trials on patients affected by stroke. ]]></summary_en></project><project>
<id>4209</id><title_hr><![CDATA[Hrvatska longitudinalna studija tjelesne aktivnosti u adolescenciji]]></title_hr><title_en><![CDATA[Croatian Physical Activity in Adolescence Longitudinal Study]]></title_en><user_id>523</user_id><user_firstLast_name>Marjeta Mišigoj-Duraković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-9926</code><acronim><![CDATA[CRO-PALS]]></acronim><duration>01.12.2016 - 30.11.2020</duration><status>Završio</status><financ_value>78.683,92 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Kineziologija, Psihologija, </scie_field_hr><scie_field_en>Kinesiology, Psychology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Kineziološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Kinesiology]]></institution_en><team_members_id>1126, 3761, 13488, 6355, 3710, 4051, 13335, 13301, 25220, 23764, 7293, 28634, </team_members_id><team_members_names><![CDATA[Maroje Sorić, Zvonimir Šatalić, Renata Barić, Tatjana Trošt Bobić, Dario Novak, Vilko Petrić, Antonela Devrnja, Hrvoje Podnar, Josip Karuc, Lovro Štefan, Ivan Radman, Marija Martina Glavaš, ]]></team_members_names><keywords_hr><![CDATA[tjelesna neaktivnost, zdravlje, pretilost, sedntarna ponašanja, mladež]]></keywords_hr><keywords_en><![CDATA[inactivity, health, obesity, sedentarism, youth]]></keywords_en><summary_hr><![CDATA[Nedovoljna tjelesna aktivnost (TA) na četvrtom je mjestuvodećih rizika smrtnosti u svijetu. Tijekom adolescencijesmanjuje se u oba spola, a determinante i ishodi tog smanjenjanisu u potpunosti razjašnjeni. Stoga su ciljevi ovog istraživanja:analizirati obrasce promjena TA tijekom adolescencije; identificirati determinante TA i sedentarnih ponašanja tijekom ovog razdoblja; istražiti povezanost TA i sedentarnih ponašanja sa nekim sa zdravljem povezanim ishodima; identificirati moderatore tih povezanosti. Ovaj projekt se naslanja na tekuće longitudinalno istraživanje koje je započelo 2014. godine, a obuhvaća  903 učenika iz 14 slučajno odabranih zagrebačkih srednjih škola. TA i sedentarna ponašanja se procijenjuju SHAPES upitnikom i pomoću multisenzornog monitora TA (the SenseWear Armband).Za evaluaciju motivacije koristit se &#39;The Motives for Physical Activity Measure- Revised&#39; upitnik. Trajanje spavanja ispituje se SWA monitorom i upitnikom. Dijetetske metode uključuju 24-h prisjećanje unosa hrane i upitnik o učestalosti unosa hrane. BMI, WHR i % tjelesne masti računaju se temeljem antropometrije.Krvni tlak mjeri se u skladu s ESH preporukama, a pušenje i socio-ekonomski faktori procijenjuju se upitnicima. Subjektivni osjećaj zdravlja ispituje se hrvatskom verzijom upitnika KIDSCREEN-27, a koncept mentalnog zdravlja primjenom &#39;&#39;TheStrengths and Difficulties Questionnaire&#39;&#39;. Mjeru školskog uspjeha čini prosjek ocjena na kraju školske godine. Obrada podataka temeljit će se većinom na višerazinskom modeliranju za ponavljana mjerenja. Rezultati ovog projekta omogućit će bolje razumijevanje determinanti i moderatora TA i sedentarnih ponašanja u mladih. Nadalje, rasvijetlit će se relativna uloga TA i sedentarnih ponašanja u povezanostima sa zdravstvenim ishodima, što će doprinijeti i znanstveno utemeljenom planiranju ciljanih intervencijskih programa primarne prevencije kroničnih bolesti.]]></summary_hr><summary_en><![CDATA[Lack of physical (PA) is recognized as the fourth leading risk for global death. During adolescence PA declines in both genders. Still, determinants and outcomes of this decline remain to be clarified. The aims of this study are: to analyze patterns ofchange in PA during adolescence; to identify determinants and moderators of PA and sedentary behaviours in this period; to explore the effect of PA and sedentary behaviours on several health related outcomes; to examine how different correlates of PA moderate the effect of PA and sedentary behaviours on health-related outcomes. The project extends on the on-going prospective longitudinal study that started in 2014 and involves around 900 high school students from the city of Zagreb (Croatia). PA and sedentary behaviours are assessed annually during 4 years of high school education by the SHAPES questionnaire and by the SenseWear Armband multiple-sensor activity monitor. Motivation for PA is evaluated by &#39;The Motives for Physical Activity Measure - Revised&#39; and perceived health by the KIDSCREEN-27 questionnaire. Sleep is examined using several self-report instruments and by the SWA monitor. The 24-h dietary recall and a food frequency questionnaire are applied. BMI, WHR and body fat percentage will be calculated based on anthropometry. Blood pressure is  taken following ESH guidelines. Smoking and socioeconomic factors will be assessed through questionnaires. Mental health is evaluated by the Strengths and Difficulties Questionnaire; grade point average will be used as a measure of academic achievement. Data analytic techniques will mostly rely on multi-level modelling for repeated measures. The results of this study will aid in understanding PA decline in youth, its determinants and moderators. In addition, the relative importance of PA and sedentary behaviours for physical and mental health will be elucidated. Consequently, future interventions aimed at primary prevention of chronic diseases will be improved.]]></summary_en></project><project>
<id>4226</id><title_hr><![CDATA[Ravni Kotari: urbanizacija i promjene krajolika u sjevernoj Dalmaciji]]></title_hr><title_en><![CDATA[Ravni Kotari: Urbanization and Landscape Change in Northern Dalmatia]]></title_en><user_id>5152</user_id><user_firstLast_name>Martina Čelhar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-5832</code><acronim><![CDATA[URBANIZACIJA]]></acronim><duration>20.03.2017 - 19.03.2020</duration><status>Završio</status><financ_value>53.335,31 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Arheologija, Povijest, Etnologija i antropologija, </scie_field_hr><scie_field_en>Archeology, History, Ethnology and anthropology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zadru]]></institution_hr><institution_en><![CDATA[University of Zadar]]></institution_en><team_members_id>20207, 4817, 20172, 20208, 20304, 26316, 26317, 26318, 26023, </team_members_id><team_members_names><![CDATA[Gregory Zaro, Igor Borzić, Karla Gusar, Ken Nystrom, Tajana Trbojević Vukičević, Luka Bogdanić, Antonela Klobučar, Vinka Milišić, Maja Grgurić, ]]></team_members_names><keywords_hr><![CDATA[Urbanizacija, krajolik, Ravni Kotari, sjeverna Dalmacija, Nadin-Gradina, željezno doba, antika, kasna antika, srednji vijek, novi vijek]]></keywords_hr><keywords_en><![CDATA[Urbanization, Landscape, Ravni Kotari, northern Dalmatia, Nadin-Gradina, Iron Age, Antiquity, Late Antiquity, Medieval period, Modern Era]]></keywords_en><summary_hr><![CDATA[Gradovi su danas dominantan faktor u globalnim promjenama okoliša, no kao dugotrajan proces urbanizacija je imala značajnu ulogu u oblikovanju krajolika i okoliša tijekom tisućljeća, efektivno stvarajući kulturne krajolike. Ova činjenica otvara prostor arheologiji da značajno doprinese suvremenim urbanim i ekološkim pitanjima, usput generirajući  međukulturalno znanje o procesu urbanizacije u širokom vremenskom okviru od kasne prapovijesti pa sve do suvremenog doba. Iako taj proces na prostoru istočnog Jadrana traje već nekoliko tisućljeća, on nije ni približno dovoljno rasvijetljen. Čak i Ravni Kotari, smješteni u zaleđu Zadra, tijekom antike nedvojbeno najurbaniziranija istočnojadranska regija, tek trebaju dobiti značajniju arheološku pažnju usmjerenu k istraživanju razvoja urbanizacije te njezina utjecaja na lokalne i regionalne promjene u krajoliku.Predloženi projekt je interdisciplinarne prirode te kombinira arheološka iskopavanja i analize s povijesnim i arhivskim istraživanjima, teritorijalnim studijama, bioarheološkim ispitivanjima, znanostima o okolišu, a sve da prouči proces urbanizacije i transformacije prostora Ravnih Kotara kroz vrijeme. Veći dio terenskih istraživanja će se odvijati na arheološkom lokalitetu Nadin-Gradina. Tamošnja situacija će se komparirati s poznatim podatcima vezanima također uz prostor Ravnih Kotara, ali i čitave istočne obale Jadrana zbog jasnije kontekstualizacije urbanog razvoja i promjena praćenih tijekom zadnja 3 tisućljeća. S obzirom na odličnu očuvanost arheološkog zapisa i naseobinsku aktivnost u trajanju od gotovo 2 500 godina, lokalitet Nadin-Gradina pruža odličnu mogućnost za istraživanje odnosa između pojedinih faza urbanog rasta i opadanja te širih promjena krajolika i okoliša. Rezultati projekta će proširiti znanje o dinamici razvoja kulturnog krajolika na istočnoj obali Jadrana te upotpuniti globalnu raspravu o urbanizaciji i promjenama krajolika kroz sva razdoblja ljudske povijesti. ]]></summary_hr><summary_en><![CDATA[Cities are a dominant factor in global environmental change today, but as a long-term process, urbanization has played a significant role in shaping our planet’s landscapes and environments for millennia, effectively creating anthropogenic landscapes. Recognition of this point opens the door for archaeological research to make significant contributions to contemporary urban/ecological issues while also generating cross-cultural knowledge about urbanism in the ancient, historic, and modern worlds. In the eastern Adriatic, this process has unfolded over the course of several thousand years but is not well understood. Even the Ravni Kotari region in Zadar&#39;s hinterland, arguably the most urbanized region along the entire coast in antiquity, has yet to receive significant archaeological attention regarding the process of urban growth and decline, or its articulation with and impact on local and regional landscape change. The proposed project is an interdisciplinary field research program that combines archaeological excavation and analysis with historical and archival research, geospatial studies, bioarchaeological investigation, and environmental science. The majority of field research will take place at the Nadin-Gradina archaeological site, but it will also draw comparatively from published work throughout the Ravni Kotari and eastern Adriatic to contextualize urban development and change around Nadin-Gradina over the course of three thousand years. With a nearly 2,500-year record of seemingly well-preserved occupational history, Nadin-Gradina offers an excellent opporunity to investigate the relationship between phases of urban growth and decline and broader changes in landscape and environment. The results of this project will help to build a range of knowledge concerning human-environment dynamics in the eastern Adriatic while also contributing to a global discussion on urbanization and landscape change in the ancient, historic, and modern worlds. ]]></summary_en></project><project>
<id>4228</id><title_hr><![CDATA[TFF3 protein na raskrižju metabolizma i neurodegeneracije]]></title_hr><title_en><![CDATA[TFF 3 protein at intersection of metabolism and neurodegeneration ]]></title_en><user_id>1263</user_id><user_firstLast_name>Mirela Baus Loncar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-2717</code><acronim><![CDATA[Inter MeNe-3]]></acronim><duration>18.04.2017 - 17.03.2022</duration><status>Završio</status><financ_value>131.395,58 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>19273, 13089, 19240, 25290, 24803, </team_members_id><team_members_names><![CDATA[Friedrich Paulsen, Nikola Bijelić, Ivana  Lovrić, Iva Bazina, Kate Šešelja, ]]></team_members_names><keywords_hr><![CDATA[Tff3 protein, jetra, mozak, diabetes, neurodegeneracija, Alzheimerova bolest homeostaza  glukoze, stres endoplazmatskog retikuluma  ]]></keywords_hr><keywords_en><![CDATA[Tff3 protein, liver, brain, diabesity, neurodegeneracija, Alzheimer disasese, glucose homeostasis, endoplasmatic reticulum (ER) stress  ]]></keywords_en><summary_hr><![CDATA[Većina bolesti koje prate užurbani životni ritam su povezane sa poremećenim metabolizmom glukoze i lipida. Diabetes i Alzheimerova bolest (AB) su među najvećim prijetnjama današnjice. Obje bolesti  u podlozi imaju neosjetljivost na inzulin i zajedničke upalne signalne putove. Kliničke i pred kliničke studije pokazale su  da je AB degenerativna metabolička bolest, posredovana narušenim inzulinskim signaliziranjem u mozgu, poremećenim iskorištenjem glukoze i energetskog metabolizma koji dovode do oksidativnog stresa, upale i pogoršanja inzulinske  neosjetljivosti. Veza između diabetes/debljine i AB, može razjasniti mehanizam nastanka sporadične AB koja se javlja kod 90% AB pacijenata. Potraga za biomarkerima u likvoru  AB pacijenata otkrila  je  TFF3 protein (Trefoil factor family protein 3) kao mogućeg povezujućeg kandidata. Nova istraživanja pokazala su da bolest nealkoholna masna jetra izazvana masnom hranom u mišjem modelu može uzrokovati sve simptome AB uključujući i smrt neurona. Dramatično smanjenje razine Tff3 glasničke RNA u jetri uočena je u ranoj fazi diabetesa kod mišjeg modela diabetes Tipa 2 (Tally Ho). Tff3 protein je prisutan u neuronima a Tff3 iz jetre može djelovati neuroprotektivno i nakupljati se u mozgu nakon ozljede. Cilj ovog projekta je utvrditi ulogu Tff3 proteina u Jetri/mozgu koristeći Tff3 -/- mišji soj i modelirajući diabetesa tipa 1 i tipa 2. Korelirati ćemo učinak nedostatka Tff3 na jetru kao glavni metabolički organ i mozak (hippocampus/cortex),te pratiti specifične pokazatelje neurodegeneracije i stresa endoplazmatskog retikuluma. Koristeći novu tehnologiju (XFe96 Extracellular Flux Analyzer) utvrdit ćemo učinak Tff3 na mitohondrijsku respiraciju i glikolizu u živućim primarnim hepatocitima. Ovakav sistemski pristup pridonijeti će razumijevanju zajedničkih procesa koji se odvijaju u osnovi obje bolesti (diabetesa i neurodegeneracije), te potencijalno ukazati na nove terapijske mete. ]]></summary_hr><summary_en><![CDATA[Most of the diseases accompanying fast  life rhythm in developed countries are connected with  deregulated  lipid and glucose metabolism. Diabetes and Alzheimer’s disease (AD) are considered among top threats to human health and they both have in common insulin resistance and common inflammatory signaling pathways. Human and preclinical studies have provided convincing evidence that AD is a degenerative metabolic disease, mediated by impaired insulin responsiveness in the brain, glucose utilization and energy metabolism leading to increased oxidative stress, inflammation and worsening of insulin resistance. The connection between diabetes/obesity and AD, may shed light how sporadic AD develops. Biomarker search in cerebrospinal fluid of  AD  patients  identified  TFF3 protein as a new  possible candidate for this crosstalk. Novel research showed that non-alcoholic fatty liver disease provoked by High fat diet is able to induce hallmarks of AD and even neuronal death in wild type mice. Diminishment of liver Tff3 gene expression was noticed in early stage of diabetes in Tally Ho mouse model of Type 2 diabetes. Tff3 protein is present in neurons and liver produced Tff3 can act neuroprotective and concentrate in brain upon injury. In this project  proposal we will investigate impact of Tff3 protein in liver/brain axis using  Tff3 -/- mouse strain and modeling Type 1 and Type 2 diabesity conditions. We will correlate  the effect  of Tff3 deficiency on liver as major metabolic organ,  and hippocampus/cortex as affected brain regions is AD, monitoring neurodegenerative hallmarks and endoplasmatic reticulum stress markers. Using novel technology (XFe96 Extracellular Flux Analyzer) we will estimate impact of Tff3 on mitochondrial respiration and glycolysis in living primary hepatocytes. This systemic approach will help us understand common pathways in diabesity and neurodegeneration and possibly reveal novel therapeutic targets. ]]></summary_en></project><project>
<id>4231</id><title_hr><![CDATA[Pojavnosti moderne skulpture u Hrvatskoj: skulptura na razmeđima društveno-političkog pragmatizma, ekonomskih mogućnosti i estetske kontemplacije]]></title_hr><title_en><![CDATA[Manifestations of Modern Sculpture in Croatia: Sculpture on the Crossroads between Socio-political Pragmatism, Economic Possibilities and Aesthetical Contemplation]]></title_en><user_id>5489</user_id><user_firstLast_name>Dalibor Prančević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-2112</code><acronim><![CDATA[CROSCULPTURE]]></acronim><duration>01.03.2017 - 29.02.2020</duration><status>Završio</status><financ_value>52.959,98 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Povijest umjetnosti, Povijest, </scie_field_hr><scie_field_en>Art history, History, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>3667, 19524, 19779, 4237, 19560, 6142, 7870, 19952, 6333, 24567, </team_members_id><team_members_names><![CDATA[Ivana  Mance, Barbara Vujanović, Davorin Vujčić, Daniel Zec, DARIJA ALUJEVIĆ, Ljiljana Kolešnik, Aleksandar Jakir, Božo Kesić, Sanja ¸Horvatinčić, Dora Derado, ]]></team_members_names><keywords_hr><![CDATA[skulptura, društvo, politika, estetika, povijest umjetnosti, centar, periferija, Hrvatska]]></keywords_hr><keywords_en><![CDATA[sculpture, society, politics, aesthetics, art history, center, periphery, Croatia]]></keywords_en><summary_hr><![CDATA[Cilj projekta je „dubinsko mapiranje“ moderne skulpture u Hrvatskoj kroz različite „prostorne“ i „vremenske“ slojeve, te sagledavanje specifičnih okolnosti unutar kojih se ona oblikovala. Kiparska produkcija u Hrvatskoj promatrala bi se ponajprije u odnosu na europsku umjetničku produkciju, istražilo bi se njezino snalaženje u neprekidnim promjenama kako državnih asocijacija tako i društveno-političkih paradigmi i politikâ identiteta, ali i nastajanje u posebnim ekonomskim prilikama. Istraživanjem bi se pratila i notirala kretanja kipara različitim europskim političkim i kulturnim geografijama. Cilj istraživačkog tima jest razviti nove metode opisivanja vremenskih, prostornih i terminoloških definicija moderne skulpture u Hrvatskoj. Fokus istraživanja kiparska je produkcija nastajala u razdoblju koje započinje na kraju 19. stoljeća i zaključuje se sedamdesetih godina 20. stoljeća. Pritom će se u razmatranje uzeti društvo, politika, ekonomija i estetika. U pripremi projektnog prijedloga uvažila se i činjenica kako je dobar dio kiparske produkcije u Hrvatskoj nastajao eksteritorijalno. Stoga bi se istraživanjem propitalo u kojoj mjeri i na koje načine su hrvatski kipari diseminirali nove pristupe angažmana u kiparstvu, koji su to specifični protagonisti i kako se i može li se kroz njihovo djelovanje postaviti okvir diskursa o „deprovincijalizaciji“ hrvatskog kulturnog prostora. Vizualizacije takvih odnosa realizirale bi se posebnim softverskim alatima, već poznatima području djelovanja digitalne humanistike. Nadalje, posebno bi se istražile i sve one pojave kiparstva isključene iz dominantnih narativa, poput primjerice rodnih pitanja. Zasebni dio projektnog prijedloga uključuje stvaranje rječnika skulpture dvadesetog stoljeća kojim bi se stvorio tezaurus termina što se vezuju uz pojavu skulpture i njezinu artikulaciju. Rezultati istraživanja bili bi predstavljeni na međunarodnim konferencijama i okruglim stolovima, te u objavljenim recenziranim radovima i knjigama.]]></summary_hr><summary_en><![CDATA[The aim of the project is to come to an “in-depth mapping” of Modern sculpture in Croatia, with regards to various „spatial“ and „time“ layers, as well as investigation of the specific context within which Modern sculpture was shaped. Sculptural production in Croatia is to be observed in relation to European art, and in the context of constant change of state associations, different socio-political paradigms and identity politics, but also in relation to the economic situation. The research also aims to trace the movement of sculptors and their work throughout various European political and cultural geographies. Research team aims to develop new descriptions of the terms of reference within time, spatial and terminological definitions of Modern sculpture in Croatia. The main research focus will be on sculptural production in the period beginning at the end of the 19th century until the 1970s. Society, politics, economy, aesthetics will be taken into consideration. During the preparation of the project proposal it became clear that a reasonable part of Croatian sculpture was created extraterritorially. This research will investigate how and to what measure Croatian sculptors disseminated new approaches to sculptural activity, who are the specific protagonists, and how is it possible to establish a discourse frame dealing with ”de-provincialisation” of Croatian cultural space. Visualisations of such relations are to be displayed using special software tools, well known in the area of digital humanities. Furthermore, the aim is to research all those phenomena in the domain of sculpture that were excluded from the dominant narratives, for example gender issues. Special part of the project includes generating 20th century sculpture vocabulary, in order to create a thesaurus of terms that are related to the manifestation of sculpture and its articulation. Research results will be presented at international conferences, via reviewed papers and in books.]]></summary_en></project><project>
<id>4232</id><title_hr><![CDATA[Razvoj novih antitijela (biološki lijek) koja selektivno inhibiraju izražaj hepcidina u jetri za terapiju anemije kronične bolesti]]></title_hr><title_en><![CDATA[Development of novel antibodies (biologics) that will selectively inhibit hepcidin expression in the liver for the Treatment of Anemia of Chronic Disease]]></title_en><user_id>7659</user_id><user_firstLast_name>Slobodan Vukičević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-2169</code><acronim><![CDATA[BMP6Fe3]]></acronim><duration>01.07.2017 - 30.09.2022</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, Clinical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>12659, 20189, 13334, 19452, </team_members_id><team_members_names><![CDATA[Igor Erjavec, IRENA POPEK, Hermann Oppermann, Ines Oršolić, ]]></team_members_names><keywords_hr><![CDATA[hepcidin, poremečaj metabolizma željeza, anemija kronične bolesti, BMP6, hemojuvelin]]></keywords_hr><keywords_en><![CDATA[hepcidin, iron metabolism alterations, anaemia of chronic disease, BMP6, hemojuvelin]]></keywords_en><summary_hr><![CDATA[Hepcidin je peptid od 25 aminokiselina sintetiziran u jetri te služi kao ligand za feroportin i regulira homeostazu željeza. U ovom projektu pokušat ćemo razviti terapiju za anemiju kronične bolesti (AKB) povezanu s poremećajem u metabolizmu željeza temeljem našeg nedavnog otkrića da BMP6 regulira sintezu hepcidina*. Također smo otkrili da feri (Fe3+) željezo utječe na promjenu strukture BMP6 čime povećava afinitet jetre za BMP koreceptor hemojuvelin (HJV) rezultirajući povećanim izražajem gena za hepcidin i posljedično sniženom razinom serumskog željeza (preliminarni neobjavljeni rezultati). Stoga pretpostavljamo da se željezo specifično veže na cirkulirajući BMP6 i uzrokuje strukturalne promjene stimulirajući vezanje BMP6-Fe3+ kompleksa na HVJ/BMPRI i povećani izražaj gena za hepcidin u jetri, te posljedično smanjenje razine serumskog željeza. U ovom projektu predlažemo novi znanstveni koncept za razumijevanje mehanizma kojim BMP6 &#39;&#39;prepoznaje&#39;&#39; željezo i razvoj nove terapijske platforme za liječenje AKB kroz slijedeće ciljeve: 1) identifikacija fiziološkog oblika BMP6 u cirkulaciji, 2) proizvodnja rekombinantnog humanog BMP6, 3) karakterizacija specifičnih vezivnih mjesta željeza na BMP6 proteinu, 4) proizvodnja visokoafinitetnog mišjeg i humanog protutijela na strukturno promijenjen BMP6 čime bi se spriječilo stvaranje kompleksa BMP6-HJV u jetri, i time postaviti temelje za 5) testirati novoproizvedena protutijela in vitro i in vivo u modelima anemije udružene s upalom i u modelu kronične bolesti bubrega. Stoga ćemo testirati novi koncept za razumijevanje mehanizma kojim BMP6 „prepoznaje“ željezo, i upotrijebiti taj fenomen da Fe3+/BMP6/HJV posredovan izražaj hepcidina može poduprijed razvoj prvog biološkog lijeka za AKB.* Andriopoulos B, Jr., et al. (2009) Nat Genet 41:482.]]></summary_hr><summary_en><![CDATA[Hepcidin is a 25 amino acid peptide synthesized in the liver and serves as a ligand for ferropoortin, an iron exporter, and thus regulates iron homeostasis. In this project, we aim to develop a therapy for anemia of chronic disease (ACD) associated with an altered iron metabolism based on our discovery that BMP-6 regulates hepcidin synthesis*. We showed that Bmp6-/- mice have decreased hepcidin synthesis in liver and this leads to abundant accumulation of iron in the organism (“hemochromatosis”), suggesting a key role of BMP-6 in hepcidin regulation and iron metabolism. We recently found that ferric (Fe3+) iron induces conformational changes in BMP-6 secondary and tertiary structure thereby exhibiting an high affinity (~4-fold) to BMP co-receptor hemojuvelin (HJV), which results in increased expression of hepcidin and subsequently a decrease of serum iron level (preliminary unpublished results). We propose a new scientific concept to unravel the mechanism by which BMP-6 “senses” iron and develop a novel therapeutic biologics for treating ACD by following objectives: 1) identify physiological forms of circulating BMP-6, 2) produce recombinant human BMP-6, 3) characterize iron specific BMP-6 binding sites, 4) develop high affinity mouse and human antibody to structurally changed BMP-6 in order to prevent the formation of BMP-6-HJV complex in the liver; and pave the path to 5) evaluate newly developed antibodies in vitro and in vivo against anemia associated with inflammation and in a model of chronic kidney disease. Thus, we seek to demonstrate novel concept for understanding the mechanism by which BMP-6 “senses” iron, and utilizes this phenomenon that curtailing Fe3+/BMP-6/HJV mediated hepcidin expression may help to develop the first-in class biologics for ACD. * Andriopoulos B, Jr., et al. (2009) Nat Genet 41:482.]]></summary_en></project><project>
<id>4233</id><title_hr><![CDATA[Nastajanje i svojstva 1D a-Fe2O3 nanostruktura dopiranih odabranim metalnim ionima]]></title_hr><title_en><![CDATA[Formation and properties of 1D a-Fe2O3 nanostructures doped with selected metal ions]]></title_en><user_id>1073</user_id><user_firstLast_name>Stjepko Krehula</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-8254</code><acronim><![CDATA[1D-DopedFeOX]]></acronim><duration>15.03.2017 - 14.03.2021</duration><status>Završio</status><financ_value>102.196,56 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>1073, 490, 4103, 5300, 615, 25288, 28878, </team_members_id><team_members_names><![CDATA[Stjepko Krehula, Željka Petrović, Marijan Marciuš, Ivana Opačak, Svetozar Musić, Nina Popov, Marko Robić, ]]></team_members_names><keywords_hr><![CDATA[a-Fe2O3, 1D nanostrukture, dopiranje, Mossbauerova spektroskopija, elektronska mikroskopija, magnetska svojstva, fotokataliza]]></keywords_hr><keywords_en><![CDATA[a-Fe2O3, 1D nanostructures, doping, Mossbauer spectroscopy, electron microscopy, magnetic properties, photocatalysis]]></keywords_en><summary_hr><![CDATA[U zadnje vrijeme 1D (jednodimenzijski) željezovi oksidi su predmet brojnih fundamentalnih istraživanja kojima se žele polučiti nova saznanja o kemijskim i fizičkim svojstvima tih materijala te na temelju toga predložiti primjene u različitim tehnologijama, posebno u naprednim. Pri tome je važno uspostaviti odnose između vrste i uvjeta kemijske sinteze te svojstava istraživanog materijala kao što su morfologija i veličina čestica s promjenama u strukturnim, magnetskim i optičkim svojstvima. Cilj predloženih istraživanja je polučiti nova saznanja o kinetici, faznoj transformaciji i mehanizmu nastajanja 1 D a-Fe2O3. Kontroliranim dopiranjem odabranim metalnim ionima, nastojat će se poboljšati optička, magnetska i katalitička svojstva 1D a-Fe2O3. Istraživat će se nanostrukture u području od finih anizotropnih nanočestica do nekoliko stotina mikrometara dugih nanovlakana. Budući da formiranje specifičnih nanostruktura ovisi o brojnim eksperimentalnim parametrima, posebna pažnja će se posvetiti praćenju kinetika te faznim transformacijama tijekom nastajanja nanostruktura a-Fe2O3 upotrebom sofisticiranih strukturnih, mikroskopskih i spektroskopskih instrumentalnih tehnika. Za ostvarenje postavljenih ciljeva predlažu se sljedeća istraživanja: (I) praćenje kinetike i fazne transformacije nastajanja nedopiranih i dopiranih 1D a-Fe2O3 nanostruktura iz koncentriranih ili djelomično neutraliziranih otopina FeCl3, (II) razvoj novih sintetčkih postupaka dobivanja vrlo dugih nedopiranih i dopiranih nanovlakana a-Fe2O3 metodom elektroispredanja i (III) testiranje fotokatalitičke aktivnosti sintetiziranih 1D nanostruktura a-Fe2O3. Osim stjecanja novih temeljnih znanja o 1D nanstrukturiranim materijalima, priredit će se i materijali točno definiranih fizičko-kemijskih svojstava.]]></summary_hr><summary_en><![CDATA[1D (one-dimensional) iron oxides are in the focus of many researchers due to the importance of these materials in fundamental research and their high potential in advanced technologies. The knowledge of relationship  between the chemical and physical properties on one side and the synthesis conditions on the other is extremely important, especially when 1D iron oxides (undoped or doped) with desired properties must be designed. This proposal aims to provide new knowledge about the kinetics, phase transformation and the mechanism of the formation of 1D a-Fe2O3 in dependence of various experimental parameters. In order to pronounce their optical, magnetic and catalytic  properties control doping with selected metal ions will be performed using different experimental approaches. The 1D a-Fe2O3 oxide nanostructures will be investigated in the range from fine anisotropic nanoparticles up to several hundred microns long nanofibers. Since the formation of specific nanostructures is dependent on many experimental parameters a special attention in this proposal will be given to the monitoring of the formation kinetics and phase transformations using sophisticated instrumental techniques such as structural, spectroscopic and microscopic techniques. To achieve the objectives of the proposal the following investigations will be done: (i) monitoring the kinetics, phase transformation and mechanism of the formation of undoped and metal-doped 1D a-Fe2O3 nanostructures from concentrated or partially neutralized FeCl3 solutions, (II) development of new procedures in the formation of very long nanofibers of undoped and metal doped a-Fe2O3 using electrospinning methods and (III) testing the photocatalytic activity of synthesized 1D a-Fe2O3 nanostructures. This proposal is aimed to gain new fundamental knowledge on the formation of 1D nanostructured materials in general, but will also provide the materials with defined physicochemical properties.]]></summary_en></project><project>
<id>4234</id><title_hr><![CDATA[Genetska osnova insekticidnog potencijala dalmatinskog buhača (Tanacetum cinerariifolium /Trevir./ Sch. Bip.)]]></title_hr><title_en><![CDATA[Genetic background of Dalmatian pyrethrum (Tanacetum cinerariifolium /Trevir./ Sch. Bip.) insecticidal potential ]]></title_en><user_id>5513</user_id><user_firstLast_name>Martina Grdiša</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-9034</code><acronim><![CDATA[PyrDiv]]></acronim><duration>01.04.2017 - 31.03.2021</duration><status>Završio</status><financ_value>123.133,59 eur</financ_value><scie_area_hr>Biotehničke znanosti, Prirodne znanosti, Tehničke znanosti, </scie_area_hr><scie_area_en>Biotechnical sciences, Natural sciences, Technological sciences, </scie_area_en><scie_field_hr>Poljoprivreda, Biologija, Kemijsko inženjerstvo, </scie_field_hr><scie_field_en>Agriculture, Biology, Chemical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Agronomski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Agriculture]]></institution_en><team_members_id>19538, 7649, 13475, 13692, 770, 4498, 5829, 27500, </team_members_id><team_members_names><![CDATA[Filip Varga, Zlatko Šatović, Marija  Jug-Dujaković, Tonka Ninčević, Zlatko Liber, Martina Periša, Ivan Radosavljević, Nina Jeran, ]]></team_members_names><keywords_hr><![CDATA[biokemijska raznolikost, dalmatinski buhač, disperzija matrice u čvrstoj fazi, genetska raznolikost, insekticid, piretrin, pridruživajuće kartiranje ]]></keywords_hr><keywords_en><![CDATA[Association mapping, biochemical diversity, Dalmatian pyrethrum, genetic diversity, insecticide, MSPD, pyrethrin, Tanacetum cinerariifolium]]></keywords_en><summary_hr><![CDATA[Dalmatinski buhač (Tanacetum cinerariifolium Trevir. /Sch./ Bip.) je stranooplodna, diploidna samoinkopatibilna i termofilna vrsta iz porodice Asteraceae. Endemska je vrsta istočne obale Jadranskog mora a najbrojnije populacije rastu na ekstremno degradiranim staništima  plitkih kamenitih tala. Biljke dalmatinskog buhača tvore prirodni insekticid piretrin, koji je trenutno ekonomski najvažniji insekticid biljnog podrijetla. Uzgoj i upotreba dalmatinskog buhača u hrvatskim kućanstvima i poljoprivrednim sustavima ima dugu tradiciju. Iako ima veliko povijesno i ekonomsko značenje podaci o genetskoj i biokemijskoj raznolikosti prirodnih populacija dalmatinskog buhača gotovo ne postoje. Stoga je značaj predloženog projekta u integraciji različitih znanstvenih područja kako bi se stekla nova saznanja vezana uz biokemijsku i genetsku raznolikost ove endemske i gospodarski važne biljne vrste. Ciljevi projekta su sljedeći: (i) razvitak mikrosatelitnih početnica za dalmatinski buhač, (ii) analiza genetske raznolikosti prirodnih populacija dalmatinskog buhača mikrosatelitnim i AFLP biljezima, (iii) optimizacija metode ekstrakcije disperzijom matrice u čvrstoj fazi i njena primjena u kombinaciji s HPLC-DAD u identifikaciji i kvantifikaciji sadržaja i sastava piretrina istraživanih populacija, (iv) utvrđivanje AFLP biljega vezanih za lokuse povezane sa sintezom pojedinih aktivnih sastavnica piretrina pomoću pridružujućeg kartiranja (Association Mapping) što će olakšati korištenje prirodnih populacija u oplemenjivačkim programima temeljenima na odabiru pomoću biljega (MAS-Marker Assisted Selection). Nove tehnologije i metode predložene u ovom projektu pridonijet će razvoju novih pristupa u praćenju bioraznolikosti i očuvanju biljnih genetskih izvora kao i analizi biokemijskog sastava dalmatinskog buhača. Također, dobiveni će rezultati predstavljati dobar temelj za razvoj budućih oplemenjivačkih programa i uvođenje dalmatinskog buhača u poljoprivrednu proizvodnju.]]></summary_hr><summary_en><![CDATA[Dalmatian pyrethrum (Tanacetum cinerariifolium Trevir. /Sch./ Bip.) is an outcrossing diploid, self-incompatible and thermophytic plant species of the family Asteraceae. It is restricted to the eastern coast of the Adriatic Sea, where it can be found in extremely degraded habitats with shallow rocky soils. It is the source of the most economically important natural insecticide pyrethrin. The cultivation and use of Dalmatian pyrethrum and its products are well documented in Croatian history. Despite its historical significance and economic value limited genetic and biochemical data on Dalmatian pyrethrum is available. Therefore, the importance of this project proposal lies in the integration of various scientific fields in resolving important issues concerning the genetic and biochemical diversity of Dalmatian pyrethrum. The scientific objectives of the project are: (i) development of microsatellite primers (SSR; Simple Sequence Repeats) for Dalmatian pyrethrum; (ii) utilization of newly developed SSR and Amplified Fragment Length Polymorphism (AFLP) markers in assessing genetic diversity of Dalmatian pyrethrum natural populations (iii) optimization of Matric Solid Phase Dispersion (MSPD) technique and its utilization in the extraction of pyrethrins, and identification and determination of six extracted pyrethrin components in sampled populations with High - Performance Liquid Chromatography- DAD (HPLC-DAD), (iv) identification of AFLP markers linked to the trait loci related to the content of each pyrethrin component through Association Mapping studies which will facilitate the management of natural populations in future breeding programmes based on Marker-Assisted Selection (MAS). Emerging technologies and methods proposed in this project will lead to the development of new approaches to biodiversity monitoring, plant genetic resources conservation, future breeding programmes and agricultural exploitation of Dalmatian pyrethrum.]]></summary_en></project><project>
<id>4236</id><title_hr><![CDATA[Proučavanje reperfuzijske ozljede u ljudskom srcu; sprječavanje negativnih aspekata vitalnog terapeutskog postupka]]></title_hr><title_en><![CDATA[Studying Reperfusion Injury in Human Heart; How to Combat Negative Aspects of a Life-saving Therapy]]></title_en><user_id>168</user_id><user_firstLast_name>Marko Ljubković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-6153</code><acronim><![CDATA[REFINE]]></acronim><duration>01.10.2017 - 30.09.2022</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, Clinical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Split School of Medicine]]></institution_en><team_members_id>599, 19399, 194, 19291, 25252, </team_members_id><team_members_names><![CDATA[Cristijan Bulat, Godfrey L. Smith, Jasna Marinović Ljubković, Martin Bienengraeber, Ivan Mihanović, ]]></team_members_names><keywords_hr><![CDATA[srčana, ljudska, ishemija, reperfuzija, terapija]]></keywords_hr><keywords_en><![CDATA[cardiac, human, ischemia, reperfusion, therapy]]></keywords_en><summary_hr><![CDATA[Smrtnost od kardiovaskularnih bolesti, unatoč unaprijeđenim preventivnim i terapijskim mjerama koje su rezultirale poboljšanim trendovima preživljenja zadnjih godina, još uvijek predstavlja glavni uzrok smrti u svijetu. Ponovna uspostava protoka krvi kroz prethodno začepljene ogranke koronarne arterije je glavni cilj terapeutskog postupka neophodnog u svrhu smanjenja odumiranja srčanog mišićnog tkiva. Međutim, postoji niz dokaza da i sama reperfuzija dijelom dovodi do oštećenja tkiva te da doprinosi sa čak 50% u konačnoj veličini infarkta miokarda. Stoga je veliki broj istraživanja usmjeren pronalaženju postupaka kojima bi se smanjila srčana reperfuzijska ozljeda, od kojih su neki dosegnuli i razinu kliničkih istraživanja. Međutim, rezultati provedenih kliničkih studija su bili mahom negativni, pa je translacija eksperimentalnih podataka, koji su na staničnim i životinjskim modelima bili obećavajući, dosad bila neuspješna. U predloženom projektu planiramo istražiti glavne patološke elemente reperfuzijske ozljede u srčanom tkivu bolesnika s koronarnom bolešću koji će biti podvrgnuti operaciji postavljanja srčane premosnice. Pritom ćemo koristiti suvremene eksperimentalne metode procjene razine slobodnih kisikovih radikala, parametara oštećenja mitohondrija i analize metabolita tijekom ishemije i rane faze reperfuzije, kada je poznato da se većina tkivne ozljede događa. Također planiramo razvoj eksperimentalne platforme koja će omogućiti istraživanje raznih protektivnih postupaka u ljudskom srčanom tkivu, stanicama i mitohondrijima. Svrha predloženog pristupa je omogućiti ispitivanje i translaciju eksperimentalnih rezultata dobivenih temeljnim istraživanjima u kliničku uporabu te u konačnici dati doprinos razvoju terapije reperfuzijske ozljede.]]></summary_hr><summary_en><![CDATA[Mortality due to cardiovascular diseases, despite improved preventive and therapeutic measures that resulted in beneficial trends in the last decades, still remains the main global cause of death. Re-establishment of coronary blood flow following an ischemic period is the main goal of coronary recanalization therapies and is essential for reducing myocardial ischemic damage. However, there is ample evidence that reperfusion itself, besides bringing nutrients and oxygen back to the energy-deprived myocardium, can actually further induce cardiomyocyte death. This reperfusion injury is considered to account up to 50% of the final myocardial damage. Therefore, a great number of research studies focused their efforts on finding various modes of attenuation of the reperfusion injury, with many of them reaching even clinical setting. However, due to negative results of clinical studies, translation of experimental data that showed efficient cardiac protection in cellular and animal models of ischemia-reperfusion has been largely unsuccessful. In the proposed project, we aim to investigate the main culprits of reperfusion injury in myocardial tissue obtained from patients suffering from coronary heart disease and undergoing coronary artery bypass graft (CABG) surgery. We will use state-of-the-art experimental approaches for assessment of free oxygen radicals, mitochondrial damage and metabolomic analysis during ischemia and at the early onset of reperfusion, the time-point which was shown to be responsible for the most of reperfusion injury. Moreover, we propose to develop an experimental platform for investigation of various (potentially) cardioprotective strategies in human cardiac tissue, cells and mitochondria. The purpose of such approach is to bring closer to clinics some of the experimental findings obtained in animal models of the disease and ultimately come closer to reducing the reperfusion injury.]]></summary_en></project><project>
<id>4238</id><title_hr><![CDATA[Filostratigrafija nastanka i gubitka gena]]></title_hr><title_en><![CDATA[Phylostratigraphy of gene gain and loss]]></title_en><user_id>598</user_id><user_firstLast_name>Tomislav Domazet-Lošo</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-5924</code><acronim><![CDATA[PhyLoss]]></acronim><duration>01.03.2017 - 30.06.2021</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>1280, 582, 23129, 25015, 25280, </team_members_id><team_members_names><![CDATA[Zeljka Pezer Sakac, Mirjana Domazet-Lošo, Momir Futo, Sara Koska, Nina Čorak, ]]></team_members_names><keywords_hr><![CDATA[filostratigrafija, evolucijska genomika, nastanak gena, gubitak gena, genske obitelji]]></keywords_hr><keywords_en><![CDATA[phylostratigraphy, evolutionary genomics, gene gain, gene loss, gene families]]></keywords_en><summary_hr><![CDATA[Evolucijski životni ciklus gena u genomu pokretan je procesom rađanja i umiranja gena. Mada ovaj mehanizam direktno utječe na sadržaj genoma uzrokujući dobitak i gubitak gena njegova dinamika kroz filogeniju eukariota još je nerazjašnjena. Nastanak i gubitak cijelih genskih obitelji je dodatna razina evolucijskog protoka u genomima koja je česta ali često ignorirana pojava. Za praćenje nastanka i gubitka genskih obitelji moguće je u principu koristiti filostratigrafski pristup. U ovom projektu, predlažemo stvaranje sveobuhvatne i usklađene procjene nastanka i gubitka genskih obitelji kroz filogeniju eukariota koristeći stotine eukariostkih genoma unutar filostratigrafskog okvira. Ovo znanje omogućit će nam procjenu odnosa između stopa nastanka i gubitka genskih obitelji kroz evolucijsko vrijeme i rekonstrukciju sastava genskih obitelji u predačkim genomima. Kako bi ostvarili ove ciljeve razvit ćemo nove algoritme i implementirati nove strategije računanja unutar filostratigrafskog okvira te ćemo ova rješenja učiniti javno dostupna kroz web aplikaciju.  Kada katalog nastanka i gubitka gena bude gotov cilj nam je povezati profile nastanka i nestanka gena s evolucijom fenotipova. Osim evolucijske biologije, naša kolekcija nastanka i gubitka genskih obitelji biti će vrijedan izvor informacija za različita područja uključujući komparativnu genomiku, razvojnu biologiju i translacijsku medicinu. Na primjer, biti će moguće pronaći organizme koji su ‘evolucijski nul-mutanti’ za gene povezane s patološkim promjenama kod čovjeka kao i nove gene povezane s bolestima.Osim direktne koristi od publikacija u vodećim časopisima i znanstvenih suradnji uvjereni smo da će ovaj projekt imati značajan utjecaj na trening mladih znanstvenika koje namjeravamo zaposliti na projektu i osposobiti ih za vođenje istraživanja na presjeku evolucijske i računalne biologije.]]></summary_hr><summary_en><![CDATA[The evolutionary life cycle of genes is powered by the process of gene birth and death. Although this mechanism directly impacts the genome content by generating the gain and loss of genes its dynamics within the phylogeny of eukaryotes is still unclear. The gain and loss of entire gene families is another level of the evolutionary turnover in genomes which is rather frequent but often ignored phenomena. To trace gene family gain and loss one can in principle use phylostratigraphic approach.In this project, we propose to get a comprehensive and synchronized estimate of gene family gain and loss across phylogeny of eukaryotes using hundreds of eukaryotic genomes within the phylostratigraphic framework. This knowledge will allow us to estimate rates of gene family gain and loss relate over evolutionary time, and to reconstruct the ancestral genomes. To achieve these goals we will develop novel algorithms and implement a new computational strategy within the phylostratigraphic framework which will be available as a publicly accessible web resource.   Once the catalogue of gene family gain and loss is complete, we aim to link the gene-and-loss patterns to the evolution of phenotypes. Beside evolutionary biology, our gene gain and loss collection that cover wide range of eukaryotes will provide valuable information for many fields including comparative genomics, developmental biology and translational medicine. For instance it will allow us to look for the organisms that are ‘evolutionary knockouts’ for genes related to human pathologies and to find new candidate genes for diseases.    Beyond the immediate benefits of high impact scientific publications and scientific collaboration we believe that this project will have a profound impact in training young experts that we aim to hire on the project and enabling them to lead the research at the interface between evolutionary and computational biology.]]></summary_en></project><project>
<id>4239</id><title_hr><![CDATA[Novi molekularni mehanizmi kao mete ciljanih terapija: Interakcije molekula mikroRNA i signalnog puta  Hedgehog-GLI u seroznom karcinomu jajnika]]></title_hr><title_en><![CDATA[Novel Molecular Mechanisms for New Therapeutic Approaches: Interactions of microRNAs and Hedgehog-GLI Signaling Pathway in Serous Ovarian Carcinoma]]></title_en><user_id>3089</user_id><user_firstLast_name>Sonja Levanat</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-1268</code><acronim><![CDATA[MIRnaGLI]]></acronim><duration>02.05.2017 - 01.05.2019</duration><status>Završio</status><financ_value>66.311,33 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>942, 712, 19584, 1033, 19458, 3488, 19383, </team_members_id><team_members_names><![CDATA[Vesna Musani, Petar Ozretić, Maja Sabol, Diana Trnski, Držislav Kalafatić, Tajana Amšel Zelenika, Hubert Hackl, ]]></team_members_names><keywords_hr><![CDATA[serozni karcinom jajnika, signalni put Hedgehog-GLI, mikroRNA, karcinogeneza, epigenetika, terapija]]></keywords_hr><keywords_en><![CDATA[serous ovarian carcinoma, Hedgehog-GLI signaling pathway, microRNA, carcinogenesis, epigenetics, therapy]]></keywords_en><summary_hr><![CDATA[Serozni karcinom jajnika je gorući klinički problem (visoka smrtnost zbog dijagnoze u poodmakloj fazi bolesti) čija molekularna podloga još nije dovoljno istražena. Naša dosadašnja istraživanja pokazala su promijenjenu aktivnost signalnog puta Hedgehog-GLI (Hh-Gli) u tumorima jajnika koji je normalno aktivan tijekom embriogeneze i u ranom razvoju, dok u odraslom organizmu u tumorima može biti aberantno aktivan. Pokazali smo da aberantna aktivnost tog signalnog puta u karcinomima ovarija nije rezultat ni mutacija niti epigenetskih promjena na razini hipermetilacije promotora najznačajnijih regulatora signalnog puta. Daljnji smjer istraživanja su molekule mikroRNA (miRNA), male nekodirajuće dvolančane molekule RNA, koje imaju ključnu ulogu u post-transkripcijskoj regulaciji genske ekspresije. Naši preliminarni rezultati ukazuju na postojanje povezanosti glavnih komponenti Hh-Gli puta i molekula miRNA. Želimo kroz profile miRNA i genske ekspresije pronaći molekule miRNA karakteristične za serozni karcinom jajnika visokog gradusa. Nadalje,  in vitro i in vivo metodama želimo provesti funkcionalno testiranje interakcija molekula miRNA i njihovih ciljnih gena te utjecaj izmijenjene ekspresije molekula miRNA na fenotip tumorskih stanica. Krajnji cilj projekta je pronaći nove ciljne mete koje bi doprinijele boljoj prognozi, boljim budućim terapijama kao i pojašnjavanju složenih molekularnih interakcija. Naša je hipoteza da promjene u izražaju molekula miRNA vezane uz signalni put Hh-Gli doprinose nastanku seroznog karcinoma jajnika.]]></summary_hr><summary_en><![CDATA[Serous ovarian cancer is urgent clinical problem (high mortality due to diagnosis at an advanced stage of the disease), and its molecular background is still unknown. Our previous studies showed aberrant activity of the Hedgehog-GLI (Hh-Gli) signaling pathway in ovarian tumors, which is normally active only during embryogenesis and early development, while in adults it may be aberrantly active in tumors. We have shown that aberrant activity of this signaling pathway in ovarian cancer is neither the result of mutations nor of promoter hypermethylation of the main pathway regulators. The next to study are microRNAs (miRNAs), small non-coding double-stranded RNA molecules, which have a key role in post-transcriptional regulation of gene expression. Our preliminary results indicate the connection between the main components of the Hh-Gli and miRNA molecules. We intend to combine the results of miRNA and gene profiling to find miRNAs characteristic for high-grade serous ovarian cancer, implement in vitro and in vivo methods to test functional interaction between miRNAs and their target genes and the influence of altered expression of miRNAs on the phenotype of the tumor cells. The ultimate goal of the project is to find new targets that would contribute to a better prediction, better future therapies as well as understanding the complex molecular interactions. Our hypothesis is that changes in the expression of miRNA molecules related to the Hh-Gli signaling pathway contribute to the development of serous ovarian cancer.]]></summary_en></project><project>
<id>4247</id><title_hr><![CDATA[Umrežavanje glazbom: promjene paradigmi u „dugom 19. stoljeću“ – od Luke Sorkočevića do Franje Ks. Kuhača]]></title_hr><title_en><![CDATA[Networking through music: changes of paradigms in the “long 19th century“ – from Luka Sorkočević to Franjo Ks. Kuhač]]></title_en><user_id>7808</user_id><user_firstLast_name>Vjera Katalinić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-4476</code><acronim><![CDATA[NETMUS19]]></acronim><duration>01.03.2017 - 31.10.2021</duration><status>Završio</status><financ_value>44.249,78 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Znanost o umjetnosti, </scie_field_hr><scie_field_en>Arts, </scie_field_en><institution_hr><![CDATA[Hrvatska akademija znanosti i umjetnosti]]></institution_hr><institution_en><![CDATA[Croatian Academy of Sciences and Arts]]></institution_en><team_members_id>19568, 19469, 19726, 19756, 232, </team_members_id><team_members_names><![CDATA[Stanislav Tuksar, Sara Ries, Katja Radoš-Perković, Sanja Majer-Bobetko, Ivana Horbec, ]]></team_members_names><keywords_hr><![CDATA[umrežavanje, glazba, dugo 19. stoljeće, Luka Sorkočević, Franjo Ksaver Kuhač, korespondencija, dnevnik]]></keywords_hr><keywords_en><![CDATA[networking, music, long 19th century, Luka Sorkočević, Franjo Ksaver Kuhač, correspondence, diary]]></keywords_en><summary_hr><![CDATA[Umrežavanje glazbom u „dugom 19. stoljeću“ proučavat će se komparativno na tri tematska kruga: 1) Boravak Luke Sorkočevića (1734-1789) u Beču (1781-82) i njegov dnevnik koji pruža uvid u krug istaknutih političkih, kulturnih i intelektualnih ličnosti i u sustav provođenja politike Dubrovačke Republike; 2) mapiranje dolazaka i nastupa inozemnih putujućih opernih družina i solista u Zagrebu sredinom 19. stoljeća od „prve nacionalne opere“ - Ljubavi i zlobe V. Lisinskoga (1846) do pokretanja stalne nacionalne opere u zagrebu i Zajčeva Mislava (1870); 3) obrazovna i istraživačka povezivanja F. Ks. Kuhača (1834-1911) sa skladateljima, muzikografima i melografima srednje i jugoistočne Europe kroz prizmu korespondencije te objavljene dokumentacije i njegovih radova. Uz arhivska i terenska istraživanja komparativno će se analizirati izvori sačuvani u Hrvatskoj i inozemstvu (Italija, Austrija, Mađarska, Češka, Slovačka, Poljska, Srbija, Bugarska). Istraživanja će rezultirati pojedinačnim člancima i kritičkim izdanjima Sorkočevićeva dnevnika te druge i treće knjige (1864-1872) korespondencije od 13 sačuvanih iz Kuhačeve ostavštine.]]></summary_hr><summary_en><![CDATA[Networking through music in the „long 19th century“ will be comparatively investigated within three thematic areas: 1) The sojourn of Luka Sorkočević (1734-1789) in Vienna in 1781-82 and his diary which gives insight into the circle of outstanding political, cultural and intellectual figures and into the functioning of the politics led by the Dubrovnik Republic; 2) maping of arrivals and performances of foreign itinerant opera companies and soloists in Zagreb in the mid-19th century, from „first national opera“ - Lisinski&#39;s Love and malice (1846) - to the foundation of the permanent opera ensemble in Zagreb and Zajc&#39;s opera Mislav  (1870); 3) educational and research connections of Franjo Ksaver Kuhač (1834-1911) with composers, musicographers and melographers from the central and south-eastern Europe through his correspondence and published documents and his publications. Beside archival and filed research, a comparative analyses of sources preserved in Croatia and abroad (Italy, Austria, Hungary, Czechia, Slovakia, Poland, Serbia, Bulgaria) will be conducted. The research will result with articles and critical editions of Sorkočević&#39;s diary, as well as the second and third book of correspondence (1864-1872) out of 13 preserved in the legacy F. Ks. Kuhač.]]></summary_en></project><project>
<id>4249</id><title_hr><![CDATA[Signalni mehanizmi i metaboličke promjene u diferencijaciji stanica akutne mijeloične leukemije]]></title_hr><title_en><![CDATA[Signaling mechanisms and metabolic changes in differentiation of acute leukemia cells]]></title_en><user_id>4677</user_id><user_firstLast_name>Dora Višnjić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-4581</code><acronim><![CDATA[SignalmetabAML]]></acronim><duration>15.04.2017 - 14.09.2021</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>4499, 8442, 4676, 4837, 3497, 19576, 25361, 861749, </team_members_id><team_members_names><![CDATA[Drago Batinić, Antonio  Bedalov, Hrvoje Lalić, Vilma Dembitz, Klara Dubravčić, Josip Batinić, Barbara Tomić, Tomislav Smoljo, ]]></team_members_names><keywords_hr><![CDATA[signaliziranje, AMPK, diferencijacija, ciklus, leukemija]]></keywords_hr><keywords_en><![CDATA[signaling, AMPK, differentiation, cycle, leukemia]]></keywords_en><summary_hr><![CDATA[Akutna mijeloična leukemija (AML) je heterogena skupina bolesti koja je obilježena nekontroliranom proliferacijom blasta koji su zakočeni u ranoj fazi diferencijacije. Najuspješnije farmakološko liječenje AML je diferencijacijsko liječenje pomoću sve-trans-retinske kiseline (ATRA, prema engl. all-trans retinoic acid). Međutim, ATRA se rabi isključivo u liječenju akutne promijelocitne leukemije (APL),  podvrste AML koja sadrži translokaciju t(15;17). Svi ostali oblici AML liječe se intenzivnom kemoterapijom koja nije značajno povećala trajanje remisije ili opće preživljenje. Naše nedavno istraživanje pokazalo je da 5-aminoimidazol-4-karboksamid ribonukleozid (AIKAR, akadezin) potiče apoptozu i pospješuje diferencijaciju staničnih linija AML koje nisu APL, ali je mehanizam djelovanja AIKAR-a još uvijek nepoznat. Stoga je svrha predloženih istraživanja određivanje mehanizama koji su odgovorni za povoljno djelovanje AIKAR-a u stanicama non-APL AML te otkrivanje signalnih mehanizama i metaboličkih promjena koje su odgovorne za monocitnu i granulocitnu diferencijaciju stanica AML. U istraživanju ćemo rabiti komercijalne stanične linije AML da bismo opisali: a) ulogu i mehanizam autofagije u monocitno/makrofagnoj i granulocitnoj diferencijaciji, b) promjene u metabolizmu tijekom diferencijacije i prolaska kroz stanični ciklus, te c) ulogu deacetilaza Sirt u monocitno/makrofagnoj i granulocitnoj diferencijaciji staničnih linija AML. Dodatno, ispitat ćemo učinke AIKAR-a in vitro na uzorcima blasta izoliranih iz oboljelih od AML. Istraživanja signalnih mehanizama odgovornih za diferencirajući učinak u leukemijskim stanicama mogu u konačnici pridonijeti uspješnijem liječenju oboljelih od AML.]]></summary_hr><summary_en><![CDATA[Acute myeloid leukemia (AML) is a heterogeneous group of diseases characterized by clonal proliferation of blasts that are blocked at an early stage of differentiation. The most successful pharmacological therapy of AML is differentiation therapy with all-trans-retinoic acid (ATRA); however, ATRA-based therapy is restricted to acute promyelocytic leukemia (APL), a particular subtype that carries t(15;17) translocation. All other AMLs are treated with intensive chemotherapy, which have not significantly improved the disease-free or overall survival. Our recent study demonstrated that 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR, acadesine) induces apoptosis and enhances differentiation of non-APL AML cell lines, but the mechanism is still unknown. Therefore, proposed studies are aimed to determine the mechanism responsible for beneficial effects of AICAR in non-APL AML cells and to further elucidate signaling mechanisms and metabolic changes responsible for monocytic and granulocytic differentiation of AML cells. We will use commercially available AML cell lines to define: a) the role and the mechanism of autophagy in monocytic/macrophage and granulocytic differentiation, b) the changes in metabolism during differentiation and cell cycle progression, and to determine c) the role of Sirt deacetylase in monocytic/macrophage and granulocytic differentiation of AML cell lines. In addition, in vitro profiling of the sensitivity of primary AML samples to AICAR will be performed. The proposed project aims to define signaling mechanisms responsible for differentiation of leukemia cells, which may eventually lead to the development of an improved therapy, thus contributing to well-being of AML patients.]]></summary_en></project><project>
<id>4250</id><title_hr><![CDATA[Novi biomarkeri kronične bolesti presatka protiv primatelja]]></title_hr><title_en><![CDATA[New biomarkers in chronic Graft-versus-Host disease]]></title_en><user_id>19447</user_id><user_firstLast_name>Dražen Pulanić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-8046</code><acronim><![CDATA[Bio-cGVHD]]></acronim><duration>20.03.2017 - 19.03.2021</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Kliničke medicinske znanosti, Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Clinical sciences, Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>4499, 12852, 3334, 19566, 4042, 4959, 12447, 6599, 19410, 4023, 7295, 19615, 19616, 4603, 19652, 19585, 4791, 19939, 19820, 1017, 25404, 25382, 19908, 23225, 4288, 19227, </team_members_id><team_members_names><![CDATA[Drago Batinić, Ervina Bilić, Renata Zadro, Tamara Vukić, Radovan Vrhovac, Lana Desnica, Nadira Durakovic, Zinaida Perić, Lejla Kurić, Marinka  Mravak-Stipetić, Davorka Dušek, Romana  Čeović, Ranka Serventi Seiwerth, Milan Milošević, Damir Nemet, Ernest Bilić, Branimir Anić, Steven Zivko Pavletic, Tajana Klepac Pulanić, Maja Pučić Baković, Maria Radman, Antonela Samardžić, Antonija Babić, Nina Šaban, Vesna Kušec, Ana Zelić Kerep, ]]></team_members_names><keywords_hr><![CDATA[kronična bolest presatka protiv primatelja, biomarkeri, alogena transplantacija krvotvornih matičnih stanica, vWF, faktor VIII, glikani, imunologija]]></keywords_hr><keywords_en><![CDATA[chronic Graft-versus-Host disease, biomarkers, allogeneic hematopoietic stem cell transplantation, vWF, factor VIII, glycans, immunology]]></keywords_en><summary_hr><![CDATA[Kronična bolest presatka protiv primatelja (eng. chronic Graft-versus-Host disease, cGVHD) je multiorganska aloimuna i autoimuna bolest koja je najvažnija kasna komplikacija nakon alogenične presadbe krvotvornih matičnih stanica (aloPKMS) i vodeći uzrok ne-relapsnog morbiditeta i smrtnosti nakon aloPKMS. Zapažena incidencija bolesti kreće se između 30-70% nakon aloPKMS i povećava se zbog sve manjeg peritransplantacijskog mortaliteta, starije dobi transplantiranih bolesnika, češće upotrebe perifernih krvotvornih matičnih stanica i sve većeg broja transplantacija od nesrodnog davatelja. Bolest je kompleksna i obično zahvaća više različitih organskih sustava (kožu, oči, usta, jetru, gastrointestinalni sustav, pluća, muskuloskeletni sustav i genitourinarni sistem), a često se prezentira manifestacijama koje nalikuju na promjene u autoimunosnih bolesti. Nužno je pronalaženje prediktivnih i dijagnostičkih biomarkera koji bi koristili u procjeni rizika nastanka, dijagnoze i praćenja, procjene ativnosti i ishoda kroničnog GVHD. U Kliničkom bolničkom centru Zagreb 2013. godine osnovan je multidisciplinarni tim stručnjaka za cGVHD po uzoru na onaj formiran na National Institutes of Health (NIH, Bethesda, SAD). Osim što doprinosi poboljšanju skrbi za cGVHD pacijente, ovaj tim omogućuje preciznu interdisciplinarnu kliničku i laboratorijsku evaluaciju bolesti, prikupljanje bioloških uzoraka te nudi veliki potencijal za ispitivanje biomarkera ove teške i potencijalno smrtonosne kasne komplikacije nakon aloPKMS.Cilj ovog novog četverogodišnjeg projekta je prospektivnim longitudinalnim istraživanjem ispitati moguće nove biomarkere kroničnog GVHD (analizu glikana, faktora koagulacije, laboratorijskih parametara upale, B limfocita i monocita) uz detaljno kliničko multidisciplinarno evaluiranje bolesnika korištenjem suvremenih NIH standarda za cGVHD. ]]></summary_hr><summary_en><![CDATA[Chronic graft-versus-host disease (cGVHD) is a multi-organ alloimmune and autoimmune disorder and the most important late complication after allogeneic hematopoietic stem cell transplantation (alloHSCT). It is the major cause of non-relapse morbidity and mortality after alloHSCT. Reported incidence rates of cGVHD range from 30-70% of patients after alloHSCT, and are increasing due to lower peritransplant mortality, older recipients, the more frequent use of peripheral blood graft, and more unrelated donors. It is a complex and multisystem disease, affecting skin, eyes, mouth, liver, gastrointestinal tract, lungs,  muscular-skeletal system, and genital tract, often resembling manifestations of various autoimmune diseases. Predictive and diagnostic biomarkers of cGVHD are much needed to predict its onset, diagnose and monitor the disease, prognoses its course and outcome, and characterize its activity. At the University Hospital Center Zagreb a multidisciplinary team for cGVHD was formed in 2013 according to the team from the National Institutes of Health (NIH, Bethesda, USA).  This approach improved care of patients with cGVHD, but also provides interdisciplinary clinical and laboratory evaluation of this disease, collection of biologic samples with great potential for investigation of biomarkers of this complex and potentially lethal late complication after alloHSTC. The goal of this 4-year project is to study possible new biomarkers of cGVHD (glycan analysis, coagulation factors, laboratory markers of inflammation, B lymphocytes and monocytes) in a prospective longitudinal assessment of cGVHD patients, with their detail multidisciplinary evaluations using modern NIH standards for cGVHD.]]></summary_en></project><project>
<id>4251</id><title_hr><![CDATA[Svjetlo na molekulama: istraživanje spregnute elektronske i nuklearne dinamike]]></title_hr><title_en><![CDATA[Light on Molecules: Exploration of Coupled Electron and Nuclear Dynamics]]></title_en><user_id>2848</user_id><user_firstLast_name>Nađa Došlić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-1142</code><acronim><![CDATA[LightMol]]></acronim><duration>15.03.2017 - 14.08.2021</duration><status>Završio</status><financ_value>130.731,97 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, Matematika, Fizika, </scie_field_hr><scie_field_en>Chemistry, Mathematics, Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>3692, 19804, 5636, 19686, 2736, 25276, </team_members_id><team_members_names><![CDATA[Marko Tomislav Cvitaš, Piero Decleva, Tomislav Došlić, Davor Davidović, Jurica Novak, Tomislav Piteša, ]]></team_members_names><keywords_hr><![CDATA[neadijabatska dinamika, fotoelektronska spektroskopija, DNA, mikrosolvatacija, višekromoforni sustavi]]></keywords_hr><keywords_en><![CDATA[nonadiabatic dynamics, photoelectron spectroscopy, DNA, microsolvation, multichromophore systems]]></keywords_en><summary_hr><![CDATA[Mogućnost praćenja elektronskih i strukturnih transformacija kroz koje molekulski sustav prolazi nakon apsorpcije svjetla je dugo sanjani san. Njegovo je ostvarenje moguće samo kombinacijom teorijskih i eksperimentalnih istraživanja.  Nove spektroskopijske tehnike temeljene na interakciji s visokofrekventnim zračenjem dopuštaju istraživanje molekulske strukturne dinamike na dosad neviđenoj razini detaljnosti.  Posebno se vremenski razlučena fotoelektronska spektroskopija (TRPES) etablirala kao vodeća tehnika u tom polju. Međutim, interpretacija TRPES eksperimenata zahtijeva naprednu razinu teorije. Teorijske metode za računanje TRPES opservabli moraju biti dovoljno točne da se može uspostaviti izravna veza između strukture molekule i eksperimentalne opservable. One također moraju biti efikasne, jer simulacija vremenski razlučenih eksperimenata zahtijeva račune za stotine ili čak za tisuće molekulskih gemoetrija. Ciljevi ovog projekta su (i) poboljšanje numeričke efikasnosti računanja fotoionizacijskih opservabli. Naš cilj je učiniti vrijeme potrebno za računanje vrlo točnih udarnih presjeka i parametara asimetrije usporedivim s vremenom računanja dinamike u pobuđenim stanjima.;(ii) razvoj metoda za pouzdanije simulacije nedijabatske molekulske dinamike. To se prvenstveno odnosi na uključivanje u simulacije nuklearnih kvantnih efekata. Relaksacija pobuđenih stanja u biomolekulama često odvija  eliminacijom vodika kojeg simulacije neadijabatske dinamike često “ne vide” .(iii) poboljšanje numeričke efikasnost simulacija neadijabatske molekulske dinamike prijenosom dijela računa na grafičke procesore (GPU). To će nam omogućiti istraživanje dinamike složenih  struktura kao što su hidratirane nukleobaze, vertikalno i horizontalno povezane DNA baze.Mišljenja smo da uz korištenje naprednih algoritamskih tehnika ostvarenje sna i nije tako daleko.]]></summary_hr><summary_en><![CDATA[The possibility to follow the electronic and structural transformations that a molecular system undergoes after light absorption is a long-standing dream. The realization of this dream is possible only through a joint theoretical and experimental effort. New spectroscopic techniques based on interaction with high frequency radiation permit the investigation of molecular structural dynamics at an unprecedented level of detail. In particular, time-resolved photoelectron spectroscopy (TRPES) has emerged as the leading technique in this field. However, the interpretation of TRPES experiments requires advanced theory. Theoretical methods for calculating TRPES observables need to be accurate, so that a direct link between the structure of a molecule and the experimental observable can be established. They also need to be efficient because the simulation of time-resolved experiments requires calculations to be performed for hundreds or even thousands of molecular geometries. In order to meet these conditions, which are at the very heart of this project, advances on several fronts will be made: (i) we will improve the numerical efficiency of the computation of photoionization observables. Our goal is to make the numerical effort required for the computation of very accurate cross sections and asymmetry parameters comparable to the one for the computation of the excited state dynamics; (ii) better-quality methods for nonadiabatic molecular dynamics will be developed by the inclusion of nuclear quantum effects in simulations; (iii) we will improve the numerical efficiency of nonadiabatic molecular dynamics simulations by porting part of the calculation to graphical processor units (GPU). This will allow us to explore the dynamics of complex structures such as hydrated nucleobases, stacked and paired DNA bases.We feel that with advanced algorithmic techniques the dream is not so far away.]]></summary_en></project><project>
<id>4261</id><title_hr><![CDATA[Relacijski rodni odnosi u Hrvatskoj: modernizacijske i razvojne perspektive]]></title_hr><title_en><![CDATA[Relational Gender Identities in Croatia: Modernization and Development Perspectives]]></title_en><user_id>7730</user_id><user_firstLast_name>Inga Tomić-Koludrović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-6010</code><acronim><![CDATA[GENMOD]]></acronim><duration>01.04.2017 - 31.08.2021</duration><status>Završio</status><financ_value>79.532,82 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Sociologija, </scie_field_hr><scie_field_en>Sociology, </scie_field_en><institution_hr><![CDATA[Institut društvenih znanosti Ivo Pilar]]></institution_hr><institution_en><![CDATA[Institute of Social Sciences Ivo Pilar in Zagreb]]></institution_en><team_members_id>7070, 13277, 17800, 19082, 19080, 19604, 6746, 28943, </team_members_id><team_members_names><![CDATA[Jadranka Rebeka Anić, Lynette Šikić Mićanović, Augustin Derado, Mirko Petrić, Ivan Puzek, Željka  Zdravković, Sara Ursic, Filip Užarević, ]]></team_members_names><keywords_hr><![CDATA[muškarci, žene, rodni identitet, modernizacija, razvoj, Hrvatska]]></keywords_hr><keywords_en><![CDATA[men, women, gender identity, modernization, development, Croatia]]></keywords_en><summary_hr><![CDATA[Cilj projekta je istražiti rodne identitete muškaraca i žena u post-tranzicijskoj Hrvatskoj s motrišta novijih teorija modernizacije i teorija razvoja. Predložena tema istražit će se metodološki inovativnim pristupom, koji se temelji na mješovitim metodama i razmatra identitete muškaraca i žena u relacijskom kontekstu. Stavovi, vrijednosti i prakse muškaraca i žena u Hrvatskoj istražit će se anketnim ispitivanjem na nacionalno reprezentativnom uzorku te pomoću 100 polu-strukturiranih intervjua provođenih u kućanstvu i konceptualiziranih kao fokusirane (mikro-) etnografije. Prikupljeni kvantitativni podaci podvrgnut će se faktorskoj i klasterskoj analizi, kao i višestrukoj korespondencijskoj analizi (MCA) i geometrijskoj analizi podataka (GDA). Prikupljeni kvalitativni podaci poslužit će kao osnova za interpretaciju društvene konstrukcije roda unutar specifičnog okruženja (kućanstva) i u širem institucionalnom okruženju povezanom sa svakodnevnim praksama muškaraca i žena.Projekt se temelji na pretpostavci da se modernizacijske i razvojne sposobnosti pojedinog društva mogu procijeniti analizom rodnih odnosa. U svjetlu postavki novijih teorija modernizacije, rodne uloge i rodni odnosi mogu se vidjeti ne samo kao indikatori klasične dihotomije tradicije i modernosti, nego također i individualizacije, refleksivnosti i „samo-poduzetništva“, povezivanih s kontekstom „društva rizika“ u „drugoj moderni“. U tom smislu, njihova analiza omogućuje bogatije i preciznije razumijevanje razvojnih sposobnosti hrvatskog društva od pristupa zasnovanih na „ljudskom kapitalu“, pogotovo s obzirom na to da će istraživanje obuhvatiti i teme povezane s društvenom stratifikacijom i regionalnom diferencijacijom.Ishodi projekta bit će relevantni u kontekstu javnih politika i očekuje se da značajno pridonesu socio-ekonomskom razvoju hrvatskog društva. ]]></summary_hr><summary_en><![CDATA[This project aims to research gender identities of men and women in post-transitional Croatia from the perspectives of new modernization and development theories. It aims to research the proposed subject-matter using an innovative methodological approach based on mixed methods and viewing the gender identities of men and women in a relational context. Attitudes, values and practices of men and women in Croatia will be researched by means of a nationally representative survey but also by means of 100 semi-structured interviews conceptualized as focused (micro-) ethnographies and carried out in the household context. The gathered quantitative data will be subjected to factor and cluster analysis, as well as to multiple correspondence analysis (MCA) and geometric data analysis (GDA). The gathered qualitative data will serve as a basis for interpretation of the social construction of gender within a particular (household) setting and in wider institutional settings related to the everyday practices of men and women.The project is premised on the hypothesis that modernization and development capabilities of a given society can be assessed by means of analysis of gender relations. Set against the tenets of new modernization theories, such an analysis yields the indicators not only of the classical tradition-modernity dichotomy but also of individualization, reflexivity and “self-entrepreneurship” associated with the “risk society” context. In this sense, they offer a richer and more precise understanding of the development capacities of the Croatian society than the “human capital” approaches, especially since the research will also encompass the issues related to social stratification and regional differentiation.The outcomes of the project will be relevant in the public policy context and are expected to contribute significantly to the socio-economic development of the Croatian society.]]></summary_en></project><project>
<id>4263</id><title_hr><![CDATA[Primjena inovativnih metoda u praćenju proteolitičkih, lipolitičkih i oksidativnih procesa tijekom proizvodnje pršuta]]></title_hr><title_en><![CDATA[The application of innovative methods in monitoring of proteolytic, lipolytic and oxidative changes throughout the dry-cured ham process]]></title_en><user_id>19625</user_id><user_firstLast_name>Helga Medić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-6793</code><acronim><![CDATA[IM-HQHAM ]]></acronim><duration>01.03.2017 - 28.02.2021</duration><status>Završio</status><financ_value>132.357,82 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Prehrambena tehnologija, Biotehnologija, </scie_field_hr><scie_field_en>Food technology, Biotechnology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Food Technology and Biotechnology]]></institution_en><team_members_id>19066, 6046, 19976, 19718, 19675, 19702, 25241, 13348, </team_members_id><team_members_names><![CDATA[Kata Galić, Nives Marušić Radovčić, Mia Kurek, Eddy Listeš, Sandra Petričević, Danijel Karolyi, Ivna Poljanec, Mia Brkljača, ]]></team_members_names><keywords_hr><![CDATA[pršut, proteoliza, oksidacija proteina, masena spektrometrija, lipoliza, aroma, senzorska analiza]]></keywords_hr><keywords_en><![CDATA[dry-cured ham, proteolysis, protein oxidation, mass spectrometry, aroma, sensory analysis]]></keywords_en><summary_hr><![CDATA[Primjena novih metoda masene spektrometrije u prehrambenoj tehnologiji omogućuje bolji uvid u biokemijske procese koji se odvijaju tijekom prerade hrane, a njihovi produkti utječu na kvalitetu i nutritivnu vrijednost prehrambenih proizvoda.  S obzirom da su proteini i masti osnovne komponente pršuta, imaju značajan utjecaj na nutritivnu vrijednost, a njihovom razgradnjom tijekom proizvodnog procesa nastaju spojevi odgovorni za teksturu, boju i aromu proizvoda. Znanstveno je utvrđeno da su glavne biokemijske reakcije koje se odvijaju tijekom proizvodnje pršuta proteoliza i lipoliza te su najnovija znanstvena istraživanja u svijetu intenzivno usmjerena na proteolizu i oksidaciju proteina zbog njihovog utjecaja na kvalitetu gotovog proizvoda. Brojni čimbenici koji proizlaze iz tehnološkog procesa proizvodnje utječu na intenzitet proteolitičkih, lipolitičkih i oksidativnih procesa. Stoga je cilj ovog projekta istražiti utjecaj brzine i opsega proteolitičkih, lipolitičkih i oksidativnih procesa na teksturu, boju i aromu finalnog proizvoda, prateći promjene na proteinima i lipidima kroz cijeli proizvodni proces, korištenjem inovativnih analitičkih metoda. Odredit će se  i identificirati proteini, peptidi i amino kiseline kao i proteolitički indeks te oksidacija proteina određivanjem ukupnih proteinskih karbonila. Paralelno s navedenim, odredit će se i oksidacija masti te sastav masnih kiselina, boja, osnovni kemijski sastav, koncentracija NaCl, proteinski i neproteinski dušik te tekstura pršuta. Rezultati ovog projekta pokazat će kako se primjenom novih metoda masene spektrometrije može utvrditi odnos između uvjeta prerade, biokemijskih procesa i teksture pršuta kako bi se osigurala visoka kvaliteta proizvoda. ]]></summary_hr><summary_en><![CDATA[The application of novel mass spectrometry-based methods in food technology provides better insight into the biochemical processes that occur during the processing and their products affect the quality and nutritional value of food. Proteins and fats are major components of dry-cured ham with significant impact on the nutritional value of the product. Through their degradation during the processing arise compounds responsible for the product texture, color and flavor. It has been scientifically established that the main biochemical reactions during the production of dry-cured ham are proteolysis and lipolysis and current scientific research studies are focused intensely on proteolysis and oxidation of proteins because of their impact on the quality of the final product. Numerous factors arising from the technological process influence the intensity of proteolytic, lipolytic and oxidative processes. Therefore, the aim of this project is to investigate the influence of proteolytic, lipolytic and oxidative changes on the texture, color and flavor of the final product by monitoring changes of the proteins and lipids throughout the dry-cured ham process using innovative analytical methods. Proteins will be identified, peptides and amino acids, proteolysis index, the oxidation of proteins and protein carbonyls will be analyzed. In parallel, the oxidation of fat and fatty acid composition, color, basic chemical composition, concentration of NaCl, protein and non-protein nitrogen and texture of the ham will be determined. The results of this project will show that the application of novel mass spectrometry-based methods can help in defining the relationship among processing conditions, the biochemical processes and the texture of dry-cured ham to ensure high quality product.]]></summary_en></project><project>
<id>4267</id><title_hr><![CDATA[Strukturne dekompozicije empirijskih podataka za računalno potpomognutu dijagnostiku bolesti]]></title_hr><title_en><![CDATA[Structured Decompositions of Empirical Data for Computationally-Assisted Diagnoses of Disease]]></title_en><user_id>19111</user_id><user_firstLast_name>Ivica Kopriva</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-5235</code><acronim><![CDATA[DEDAD]]></acronim><duration>01.03.2017 - 28.02.2021</duration><status>Završio</status><financ_value>78.890,44 eur</financ_value><scie_area_hr>Tehničke znanosti, Prirodne znanosti, Biomedicina i zdravstvo, </scie_area_hr><scie_area_en>Technological sciences, Natural sciences, Biomedicine and health sciences, </scie_area_en><scie_field_hr>Računarstvo, Matematika, Kemija, Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Computer sciences, Mathematics, Chemistry, Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>3410, 3416, 5103, 715, 1288, 19259, 19142, 19164, 25398, </team_members_id><team_members_names><![CDATA[Marijana  Popović Hadžija, Mirko Hadžija, GORANA ARALICA, Lidija Brkljačić, Marijana Vučić Lovrenčić, Anteja Krištić, Fei Shi, Xinjian Chen, Dario Sitnik, ]]></team_members_names><keywords_hr><![CDATA[faktorizacije, nizak rang, rijetkost, patologija, metaboličko profiliranje ]]></keywords_hr><keywords_en><![CDATA[factorizations, low rank, sparsity, pathology, metabolic profiling]]></keywords_en><summary_hr><![CDATA[Predlaže se razvoj algoritama za dekompozicije empirijskih podataka za računalno potpomognutu dijagnostiku u patologiji, metaboličkom profiliranju dijabetesa II i optičkoj koherentnoj tomografiji oka. Za tu svrhu predlažemo dekompozicije regularizirane niskim rangom, rijetkosti, nenegativnosti i njihovim kombinacijama. Za dobivanje reproducibilnih dekompozicija predlaže se razvoj konveksnih regulariziranih nelinearnih multiplikativnih faktorizacija koje se oslanjaju na samoizražajnost empirijskih podataka. To je nedavno primijenjeno na problem grupiranja u podprostorima (GP). Fokus će biti na: (i) metodama za direktno grupiranje velikih skupova podataka, te (ii) metodama za rješenje GP problema kombinirajući globalno riješenje GP na malom slučajno odabranom trening uzorku sa (ne)linearnom regresijom na ostatku uzoraka. Dobiveni rezultati će se koristiti za validaciju računalno potpomognute dijagnostike na slici histopatoloških preparata. Pri tome će se koristiti prostorno-spektralne značajke izdvojene tenzorskom faktorizacijom temeljenom na Tuckerovom modelu. Za bolje razdvanje koreliranih čistih komponenata predlaže se razvoj algoritama za rijetkosti regulariziranu multiplikativnu faktorizaciju u Hilbertovim prostorima induciranim višetrukim jezgrama. Izdvojene komponente će biti anotirane sa bibliotekom kreiranom na projektu i sastavljenom od oko 400 1H NMR spektara čistih metabolita prisutnih u biofluidima. Razvijene metode će se primjeniti na metaboličko profiliranje i demonstrirati na identifikaciji biomarkera iz 1H NMR spektara humanog urina pozitivnog i negativnog na dijabetes II. Predlaže se kombinacija aditivnih dekompozicija koje poboljšavaju krominanciju i oštrinu slike sa naprednim algoritmima za ukljanjanje šuma u slici. Nova metoda fuzije treba rezultirati poboljšanjem performanse računalno potpomognute dijagnostike. Nadalje, strukturne aditivne dekompozicije će biti primijenjene na sliku optičke koherentne tomografije oka za potiskivanje &#39;&#39;spekla&#39;&#39;. ]]></summary_hr><summary_en><![CDATA[Project goals are related to development of algorithms for structure decompositions of empirical data for computationally assisted diagnosis in pathology, metabolic profiling of diabetes II and optical coherence tomography of an eye. Thus, we propose decompositions regularized by low-rank, sparsity, nonnegativity and their combinations. To achieve reproducible decompositions we propose development of convex regularized nonlinear multiplicative factorization methods that rely on self-expressiveness of empirical data.  That is applied recently for subspace clustering (SC). We shall focus on: (i) methods for direct SC of large scale datasets, and (ii) methods for SC that combine global solution of SC on small randomly selected training samples with (non)linear regression on the rest of the data. Obtained results will be used to validate computer-aided diagnosis using images of histopathological specimens. Thereby, texture-spectral features extracted by Tucker model based tensor factorizations will be used. For better separation of highly correlated pure components we propose derivations of sparsity regularized algorithms for multiplicative factorization in Hilbert spaces induced by multiple kernels. Separated components will be annotated with the library created on a project and compose of 400 1H NMR spectra of pure metavolites known to be present in biofluids. Derived methods will be used for metabolic profiling and demonstrated ob identification of biomarkers from 1H NMR spectra of human urine positive and negative to diabetes II. We propose to combine additive decompositions that enhance chrominance and sharpness of an image with advanced image denoising methods. New fusion method is expected to enhance performance of computer aided diagnosis. Furthermore, structural additive decompositions will be applied to optical coherence tomography image of an eye to suppress speckle. ]]></summary_en></project><project>
<id>4273</id><title_hr><![CDATA[Sustav vjetar-sunce za optimiziranu proizvodnju električne energije u rezidencijalnim objektima]]></title_hr><title_en><![CDATA[Wind-Solar System for Optimized Residential Electric Generation]]></title_en><user_id>11272</user_id><user_firstLast_name>Dinko Vukadinović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-3319</code><acronim><![CDATA[WINDSOR]]></acronim><duration>01.03.2017 - 31.08.2021</duration><status>Završio</status><financ_value>74.882,21 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Fakultet elektrotehnike, strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Electrical Engineering, Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>12326, 11307, 11280, 22821, 25306, </team_members_id><team_members_names><![CDATA[Cat Ho Nguyen, Duy Nguyen Tien, Mateo Bašić, Ivan Grgić, Matija Bubalo, ]]></team_members_names><keywords_hr><![CDATA[Proizvodnja električne energije, Samouzbudni asinkroni generator, Fotonaponski sustav, Modeliranje, Umjetna inteligencija, Optimizacija]]></keywords_hr><keywords_en><![CDATA[Electric power generation, Self-excited induction generator, Photovoltaic system, Modelling, Artificial Intelligence, Optimization]]></keywords_en><summary_hr><![CDATA[Važna motivacija za izradu predloženog projekta je potreba gradskih područja za zelenom i povoljnom energijom. U okviru ovog istraživačkog projekta razvit će se sustav za optimiziranu proizvodnju električne energije koji kao izvore električne energije sadrži vjetroagregat sa samouzbudnim asinkronim generatorom (SEIG od engl. Self-Excited Induction Generator), fotonaponski sustav i baterije. Predloženi sustav će se istraživati u otočnom režimu rada kao i s priključkom na električnu mrežu.Specifični ciljevi projekta su sljedeći: (i) Razvoj naprednog modela SEIG-a i pripadajućeg sustava vektorske regulacije s vjetroturbinom i trofaznim PWM-upravljanim ispravljačem, koji će uključivati: optimizaciju korisnosti vjetroagregata primjenom neizrazite logike; detekciju brzine vrtnje SEIG-a bez upotrebe mjernog člana; regulaciju napona SEIG-a primjenom naprednog regulatora temeljenog na teoriji algebre granica i genetičkim algoritmima te optimizaciju PWM modulacije ispravljača. (ii) Razvoj izmjenjivača kvazi Z-tipa čiji ulaz čini istosmjerna sabirnica na koju su priključeni PWM-upravljani ispravljač, fotonaponski sustav i baterije, a izlaz se koristi za napajanje trofaznih izmjeničnih trošila ili za priključak na električnu mrežu. Za potrebe sinkronizacije ovog izmjenjivača s električnom mrežom razvit će se novi sustav fazno zatvorene petlje temeljen na teoriji algebre granica i genetičkim algoritmima.(iii) Razvoj simulacijskog modela fotonaponskog sustava koji će uključivati utjecaj osunčanosti fotonaponske ćelije na njenu temperaturu, kapacitet diode fotonaponske ćelije te korekciju uobičajenog izraza za struju zasićenja diode. Za potrebe optimizacije korisnosti fotonaponskog sustava razvit će se algoritam za praćenje točke maksimalne snage, spregnut s regulacijom ulaznog napona izmjenjivača kvazi Z-tipa.Planirano istraživanje će se provesti u suradnji sa znanstvenicima iz Instituta informatičke tehnologije u Hanoju i Fakulteta elektronike u Thai Nguyenu. ]]></summary_hr><summary_en><![CDATA[An important motivation for the proposed project is the need of urban areas for green and affordable energy.Under this research project, a wind-solar system for optimized electric generation will be developed, containing a wind energy conversion system (WECS) with a self-excited induction generator (SEIG), a photovoltaic (PV) system, and batteries as sources of electric power. The proposed system will be investigated in island mode and in grid-connected mode.The specific objectives of the project are as follows:(i) Development of an advanced SEIG model and a corresponding vector control system with a wind turbine and a three-phase PWM-controlled rectifier, which will include the following features: fuzzy-logic-based optimization of the WECS’s efficiency; sensorless detection of the SEIG’s speed; control of the SEIG’s voltage by means of an advanced controller based on the hedge algebra theory and genetic algorithms, and optimization of the rectifier PWM control.(ii) Development of a quasi-Z-source inverter (qZSI) whose input is connected to a DC bus to which the PWM-controlled rectifier, the PV system, and the batteries are also connected, whereas the output of the qZSI is used for supplying three-phase AC loads or for connection to the electric grid. For the purpose of synchronization of the qZSI with the electric grid, a new phase-locked loop will be developed based on the hedge algebra theory and genetic algorithms.(iii) Development of a simulation model of the PV system including the impact of the PV cell irradiance on its temperature, the capacitance of the PV cell diode, and correction of the common term for the diode saturation current. A maximum-power-point-tracking algorithm, coupled with the control of the qZSI’s input voltage, will be developed for optimization of the PV system’s efficiency.The planned research will be carried in collaboration with researchers from the Institute of Information Technology, Hanoi, and Faculty of Electronics, Thai Nguyen.]]></summary_en></project><project>
<id>4276</id><title_hr><![CDATA[Seizmička izolacija osnove građevine s uporabom prirodnih materijala - testiranje s potresnom platformom i numeričko modeliranje]]></title_hr><title_en><![CDATA[Seismic base isolation of a building by using natural materials - shake table testing and numerical modeling]]></title_en><user_id>12821</user_id><user_firstLast_name>Jure Radnić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-5325</code><acronim><![CDATA[BASEISOLATION]]></acronim><duration>01.03.2017 - 28.02.2021</duration><status>Završio</status><financ_value>115.203,40 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Građevinarstvo, </scie_field_hr><scie_field_en>Civil engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu Fakultet građevinarstva, arhitekture i geodezije]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Civil Engineering, Architecture and Geodesy]]></institution_en><team_members_id>19696, 19701, 13117, 13151, 13353, 19464, </team_members_id><team_members_names><![CDATA[Amr Elnashai, M.Atilla Ansal, Domagoj Matešan, Nikola Grgić, Goran Baloevic, Ivan Banović, ]]></team_members_names><keywords_hr><![CDATA[Seizmička izolacija baze, aseizmički sloj, prirodni materijal, kameni oblutci, potresna platforma, numerički model]]></keywords_hr><keywords_en><![CDATA[Seismic base isolation, aseismic layer, natural material, pebbles, shake table, numerical model]]></keywords_en><summary_hr><![CDATA[Primarni cilj projekta je kreiranje i eksperimentalna provjera inovativnog koncepta za smanjenje potresnih sila na niže i srednje visoke građevine pomoću aseizmičkog sloja od prirodnih materijala ispod temelja. Predviđena su dva rješenja takvog sloja. Nakana je da takav koncept bude dostatno efikasan, racionalan i jednostavan za realizaciju, te da nađe svoju široku praktičnu primjenu. Najprije bi se eksperimentalno testirala efikasnost predviđenih aseizmičkih slojeva, varirajući više njihovih tehničko - tehnoloških parametara, s ciljem da se na građevinu prenesu što manja potresna ubrzanja (sile). Prvi aseizmički sloj je predviđen samo iz prirodnih kamenih oblutaka, a drugi od prirodnih kamenih oblutaka u kombinaciji s tankim slojem „kliznog“ materijala. Potom bi se eksperimentalno ispitalo ponašanje zgrada s prethodno navedenim aseizmičkim slojevima pri različitim potresima. Koristio bi se pojednostavljeni umanjeni modeli zgrada koji dobro simuliraju njihove dinamičke karakteristike. Testirala bi se četiri jednostupnjevna modela različite krutosti, simlirajući ponašanje građevina različite krutosti. Isti modeli zgrada bi se testirali i za slučaj bez aseizmičkog sloja, kako bi se mogla provjeriti efikasnost predviđene seizmičke izolacije.Ako bi rezultati istraživanja potvrdili očekivanja, predloženi koncept seizmičke izolacije imao bi slijedeće prednosti u odnosu na uobičajenu seizmičku izolaciju pomoću diskretnih, tehnički složenih i skupih naprava: racionalnost, jednostavnost, trajnost, proširenje tržišta, prihvatljivost za siromašnije zemlje i sl.Jedan od ciljeva projekta je razvoj numeričkog modela za pouzdanu seizmičku analizu ravninskih konstrukcija s predviđenom aseizmičkom izolacijom, kao i prijedlog jednostavnih inženjerskih izraza za proračun kapaciteta posmične nosivosti i deformabilnosti aseizmičkog sloja.Smatra se da bi uspješna realizacija predloženog projekta dala vrijedan doprinos razvoju znanosti i prakse u predmetnom području.]]></summary_hr><summary_en><![CDATA[The primary objective of the project is creation and experimental verification of an innovative concept for reducing seismic forces acting on buildings by using aseismic layer made of natural materials below foundation. Two solutions of such layer are planned. The intention is to make an efficient, rational and easy-to-implement concept, with its wide practical application. First, the effectiveness of the planned aseismic layers would be experimentally tested on the model of a rigid building, by varying several their technical - technological parameters, in order to transfer seismic acceleration (force) on the building as less as possible. The first aseismic layer is predicted as consisted only of natural stone pebbles, and the other of the natural stone pebbles in combination with a thin layer of a &#39;&#39;sliding&#39;&#39; material. Afterwards, the behaviour of real buildings with the above mentioned non-seismic layers would be experimentally tested under different earthquakes. Simplified reduced models of buildings that simulate their dynamic characteristics well would be used. Four one-degree models with different stiffness would be tested. If the results of the study would confirm expectations, the proposed concept of seismic isolation would have the following advantages compared to conventional seismic isolation using discrete, technically complex and expensive systems: rationality, simplicity, sustainability, market expansion, eligibility for poorer countries, etc. One of the objectives of the project is the development of numerical models for reliable seismic analysis of planar structures with the planned seismic isolation, as well as the proposal of simple engineering expressions for the calculation of the shear strength capacity and deformability of the aseismic layer. It is believed that the successful implementation of the proposed project would provide a valuable contribution to the development of science and practice in the concerned area. ]]></summary_en></project><project>
<id>4278</id><title_hr><![CDATA[Lobor - ranosrednjovjekovno središte moći]]></title_hr><title_en><![CDATA[Lobor – an early medieval centre of power]]></title_en><user_id>6829</user_id><user_firstLast_name>Krešimir Filipec</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-6622</code><acronim><![CDATA[LearlyCoP]]></acronim><duration>20.03.2017 - 19.08.2021</duration><status>Završio</status><financ_value>75.651,87 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Arheologija, </scie_field_hr><scie_field_en>Archeology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>12960, 13408, 13158, 12961, 13371, 19885, 5525, 13006, 12780, </team_members_id><team_members_names><![CDATA[Zdravka Hincak, Damir Mihelić, Irena Lazar, Ana Azinović Bebek, Ljubica Tomašek, Paola Iacumin Iacumin, Jana Škrgulja, Ana Mikulka, Petra Nikšić, ]]></team_members_names><keywords_hr><![CDATA[Lobor, rani srednji vijek, središte moći, grobne cjeline, arheologija]]></keywords_hr><keywords_en><![CDATA[Lobor, early middle ages, center of power, grave units, archaeology]]></keywords_en><summary_hr><![CDATA[Vidljiva arheološka kultura, ali i bogatstvo u specifičnom središtu moći, kao što je Lobor u Panoniji, korespondira s onim što donose istraživanja te analiza pripadajućih grobnih cijelina. Interdisciplinarnim istraživačkim metodama na odabranom manjem broju grobnih cjelina (80 do 100), raspoređenih od 500. do 1100. godine ispitat će se mogućnosti arheološke i povijesne interpretacije. Predviđenim istraživanjima na odabranom mikro-lokalitetu (Lobor), namjera je pridonijeti boljem razumijevanju ne samo načina pokopa u Karpatskoj kotlini, time i u srednjoj Europi, u vidu poboljšanja kronologije i metodologije istraživanja grobalja te njihova odnosa prema miljeu u kojem su nastala, već također ispitati krajnje mogućnosti arheoloških i povijesnih izvora za europsku povijest srednjeg vijeka. Istraživanje će doprinjeti rekonstrukciji svakodnevnih kulturnih navika i značajki srednjovjekovne populacije. Projekt je usmjeren na proučavanje povijesnog, kulturološkog i biološkog totaliteta ljudske populacije na određenom prostoru na određenom i jedinstvenom uzorku. Namjera je dobiti cjelovitu sliku svakodnevnih kulturnih navika i obilježja ljudi te odrediti njihove životne i radne uvjete. ]]></summary_hr><summary_en><![CDATA[A clearly discernible archaelogical culture, and the richness of one specific centre of power such as Lobor in Pannonia, corresponds with what the research and analysis of the associated grave ensembles. The possibilities of archaeological and historical interpretation will be examined, through interdisciplinary research methods, on a selected number of grave ensembles (approximately 80 to 100 grave ensembles), dating from 500 to 1000 AD. The planned researches at the selected microlocality (Lobor) are planned to contribute to a better understanding of the manner of burial in the Carpathian Basin, i.e. Central Europe in terms of improving the chronology and the methodology of the research of cemeteries and how they relate to the milieu in which they were created, and also to provide an opportunity to examine the highest possibilities for them to be used as archaeological and historical sources for the medieval history of Europe. The research will contribute to the reconstruction of everyday cultural habits and characteristics of a medieval population. The project aims to study the historical, cultural and biological totality of a human population in a particular area and on a particular and unique sample. The intention is to get a complete picture of everyday cultural habits and characteristics of the people, and to determine their living and working conditions.]]></summary_en></project><project>
<id>4281</id><title_hr><![CDATA[METALOSUPRAMOLEKULSKE STRUKTURE I ANORGANSKO-ORGANSKI POLIOKSOMETALATNI HIBRIDI ]]></title_hr><title_en><![CDATA[METALLOSUPRAMOLECULAR ARCHITECTURES AND INORGANIC-ORGANIC POLYOXOMETALATE BASED HYBRIDES]]></title_en><user_id>134</user_id><user_firstLast_name>Višnja Vrdoljak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-4221</code><acronim><![CDATA[MOLART]]></acronim><duration>01.03.2017 - 30.06.2021</duration><status>Završio</status><financ_value>113.876,17 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>358, 19078, 47, 19084, 3896, 1387, 6825, 57, 634, 5462, 346, 25322, 27400, 27133, </team_members_id><team_members_names><![CDATA[Biserka Prugovečki, Vladimir Damjanović, Marina Cindrić, Danijela Cvijanović, Dubravka Sisak Jung, Jelena Parlov Vuković, Jasna Lovrić, Jana Pisk, Mirta Rubčić, Tomica Hrenar, Ines Primožič, Mirna Mandarić, Dino  Kuzman, Edi Topić, ]]></team_members_names><keywords_hr><![CDATA[metalosupramolekulski spojevi, polioksometalati, hibridi, hidrazoni, dikarboksilati, struktura, biološka svojstva, kvantno kemijski računi]]></keywords_hr><keywords_en><![CDATA[metallosupramolecular compounds, poyoxometalates, hybrides, hydrazones, dicarboxylate, structure, biological properties, quantum chemical calculations]]></keywords_en><summary_hr><![CDATA[Glavna ideja projekta temelji se na principima koordinacijske kemije u dizajnu i sintezi novih MoVI metalosupramolekulskih struktura i organsko-anorganskih hibridnih polioksometalatnih materijala. Sinteza novih spojeva bazirat će se na “bottom-up” pristupu, odnosno njihovoj pripravi iz građevnih blokova nastalih in situ kako u otopini tako i u čvrstom stanju. To će omogućiti ispitivanje procesa samoudruživanja i kristalnog rasta navedenih sustava. Poveznica svih segmenata istraživanja je i u pronalaženju uvjeta neophodnih u kontroli sastava, strukture i svojstava ciljnih spojeva. Očekuje se da će ovo istraživanje dati uvid u mehanizme ispitivanih reakcija i omogućiti tumačenje utjecaja različitih inter- i intramolekulskih interakcija na svojstva višedimenzionalnih sustava ili njihovih građevnih blokova. Metode koje će se koristiti u sintezi organskih, metalosupramolekulskih i anorgansko-organskih polioksometalatnih hibrida bit će modificirane metode otopinske kemije, ali će se koristiti i metodologije zelene kemije. Istraživanja termički induciranih reakcija u čvrstom stanju predstavljaju dodatni izazov ovoga projekta. Predloženi projekt sastoji se od sljedećih dijelova: (i) dizajna i sinteze multifunkcionalnih N,O-donorskih liganada i ispitivanja njihovih svojstava; (ii) sinteze novih MoVI metalosupramolekulskih sustava; (iii) sinteze novih hibridnih organsko-anorganskih polioksometalatnih spojeva; (iv) karakterizacije svih priređenih spojeva; (v) kvantno-kemijskih proračuna i teorijskih tumačenja eksperimentalnih rezultata s ciljem boljeg razumijevanja i poboljšanja ispitivanih procesa; (vi) ispitivanja kemijskih i fizikalnih svojstava priređenih spojeva; (vii) ispitivanja bioloških svojstava odabranih spojeva.]]></summary_hr><summary_en><![CDATA[The main idea of the project is to apply principles of coordination chemistry to design and synthesise new MoVI metallosupramolecular architectures and POM-based organic-inorganic hybrid materials. Such systems will be developed via a bottom-up approach combining suitable building blocks generated in situ in solution as well as in the solid state. The complexity in their construction is an invaluable opportunity to study the self-assembly and crystal growth processes. Links between all segments of this research are in finding suitable conditions that are necessary to control the composition and/or structural features of target architectures. It is expected that our investigation will give insight into particular reaction mechanisms and provide explanation for the influence of different inter- and intramolecular interactions on properties of high-dimensional compounds or their building blocks. Methods used in the synthesis of organic, metallosupramolecular and inorganic-organic hybrids will be modified and performed in accordance to conventional, but also green, chemical methodologies. Investigations of thermally induced reactions in the solid state are additional challenging part of the project. The proposed project consists of the following parts: (i) design and synthesis of multifunctional N,O-donor ligands and study of their properties; (ii) synthesis of novel MoVI metallosupramolecular architectures; (iii) preparation of novel hybrid organic-inorganic compounds based on polyoxomolybdates; (iv) characterisation of all prepared compounds; (v) quantum chemical calculations and theoretical support to the experimental research which will be used to understand and guide the improved efficiency of the studied processes; (vi) investigation of chemical and physical properties of prepared compounds; (vii) investigation of biological properties of selected compounds.]]></summary_en></project><project>
<id>4282</id><title_hr><![CDATA[NRF2 na raskrižju epigenetičkog modeliranja, metabolizma i proliferacije stanice raka]]></title_hr><title_en><![CDATA[NRF2 at the crossroads of epigenetic remodeling, metabolism and proliferation of cancer cells ]]></title_en><user_id>11305</user_id><user_firstLast_name>Koraljka Gall Trošelj</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-4404</code><acronim><![CDATA[CrossEMPATICNRF2]]></acronim><duration>15.05.2017 - 14.09.2021</duration><status>Završio</status><financ_value>117.459,69 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, Clinical sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>11317, 12333, 5615, 12664, 12721, 12789, 12722, 25296, 25007, 2554, </team_members_id><team_members_names><![CDATA[Renata Novak Kujundžić, Neven Žarković, Ana Čipak Gašparović, Lidija Milković, Božo Krušlin, Young-Joon Surh, Paško Konjevoda, Anamarija Mojzeš, Marko Tomljanović, Nikola Đaković, ]]></team_members_names><keywords_hr><![CDATA[rak, NRF2, epigenetičko modeliranj, metabolizam, proliferacija, kliničko značenje]]></keywords_hr><keywords_en><![CDATA[cancer, NRF2, epigenetic remodeling, metabolism, proliferation, clinical significance]]></keywords_en><summary_hr><![CDATA[NRF2 je čimbenik transkripcije neophodan za aktiviranje mnogih enzima Faze 2 i detoksicirajućih enzima koji su stanici potrebni za funkcionalan antioksidacijski odgovor na stres. U kontekstu kemoprevencije, NRF2 štiti zdravu stanicu od slobodnih radikala i zbog toga je koristan i stanici, i domaćinu. U kontekstu zloćudne bolesti, njegova je aktivnost korisna samo zloćudno promijenjenoj stanici. Najnoviji podaci upućuju na važnost NRF2 u reguliranju transkripcije nekih metaboličkih enzima koji su, izravno ili neizravno, uključeni u nastanak pro-proliferativnog Warburgovog učinka. Na neke se od ovih enzima može vezati kurkumin. Aktivnost NRF2 je regulirana na nekoliko razina. Razina njegove transkripcije ovisi o metiliranosti DNA njegovog promotora (ova su dva parametra negativno korelirana) i postojanju represivne trimetilacijske oznake na lizinu 27 u histonu H3 (H3K27me3). Metiltransferaza histona EZH2, odgovorna za uspostavu ove epigenetske modifikacije smatra se onkoproteinom. Međutim, rezultati studija pokazuju da je njezino ispoljavanje vrlo varijabilno, a prognostička vrijednost kontradiktorna u nekim kliničkim modelima raka (rak pluća). Kako bismo shvatili uzroke ovih razlika, pratit ćemo funkciju NRF2 in vitro, u nekoliko linija stanica raka, u mirovanju i potaknutima gladovanjem i kurkuminom, na razini: a) aktivnosti promotora NRF2; b) prisustvu micro-RNA 200-a i 200-b; c) prisutnosti biljega proliferacije Ki-67; d) prisutnoj aktivnosti dobro znanih gena koje NRF2 izravno potiče (HO-1 i NOQ-1); c) prisustvu enzima koje NRF2 potiče neizravno, a koji su izravno ili neizravno uključeni u nastanak Warburgova učinka (PKM2, SHMT2). Analiza spomenutih proteina bit će, metodom imunohistokemije, napravljena i na arhivskim uzorcima tumora glave i vrata, kako bi se njihova ispoljenost korelirala s biološkim ponašanjem tumora.]]></summary_hr><summary_en><![CDATA[NRF2 is a transcription factor needed to activate Phase II- and detoxifying enzymes which are needed for functional cellular antioxidative stress response. In a chemopreventive setting, NRF2 protects healthy cells from free radicals and is beneficial for the cell and for the host. In the setting of developed malignant disease, its activity is beneficial only for the cancer cell. The most recent data point out its importance in regulating transcription of some metabolic enzymes which are included, directly or indirectly, in the onset of pro-proliferative Warburg&#39;s effect. Some of them were shown to be targets for direct curcumin binding. NRF2 activity is regulated at several levels. Its transcription was shown to be regulated by the level of DNA promoter methylation (which negatively correlates to the level of its transcription) and suppressive trimethylated marks on lysine 27 in histone 3 (H3K27me3). The histone methyltransferase EZH2, which is responsible for establishing this epigenetic modification, is considered to be an oncogene. However, studies have shown that its expression seems to be highly variable, with opposite prognostic values in some clinical cancer models (lung cancer). For understanding these discrepancies, we will follow NRF2 functioning in vitro, in several cancer cell lines, under resting and stimulated (starvation/exposure to curcumin) conditions, at the level of: a) its promoter activity, b) the presence of microRNAs 200-a and 200-b; c) the presence of proliferation marker Ki-67; d) the presence of NRF2 bona fide targets (HO-1 i NOQ-1); c) the presence of enzymes, shown to be indirect NRF2 targets, which are directly or indirectly involved in Warburg&#39;s effect (PKM2, SHMT2). The research will be translated to a clinical setting, through immunohistochemical evaluation of the expression of previously mentioned proteins in archive samples of head and neck tumors to establish a clinical value related to the biological characteristics of the tumor.]]></summary_en></project><project>
<id>4283</id><title_hr><![CDATA[Uloga heterozigotnosti gena za ribosomski protein S6 u zloćudnoj preoprazbi stanica]]></title_hr><title_en><![CDATA[Assessing the oncogenic effects of ribosomal protein S6 heterozygosity]]></title_en><user_id>7705</user_id><user_firstLast_name>Siniša Volarević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-2079</code><acronim><![CDATA[ONCO-RIB]]></acronim><duration>08.05.2017 - 07.10.2021</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Medicine]]></institution_en><team_members_id>19365, 19452, 19765, 19868, </team_members_id><team_members_names><![CDATA[Slađana  Bursać, Ines Oršolić, Moshe Oren, André Paul Gerber, ]]></team_members_names><keywords_hr><![CDATA[zloćudni tumori, ribosomski protein S6, supresor tumora p53, sinteza ribosoma, jezgrica]]></keywords_hr><keywords_en><![CDATA[cancer, ribosomal protien S6, p53 tumor suppressor, ribosome biogenesis, nucleolus]]></keywords_en><summary_hr><![CDATA[Istraživanja tijekom proteklih desetak godina dokazala su da heterozigotne mutacije specifičnih ribosomskih proteina (RP) uzrokuju patološke promjene u životinjskim pokusnim modelima i nekoliko bolesti u ljudi, uključujući 5q- mijelodisplastični sindrom, anemiju Diamond-Blackfan i brojne vrste zloćudnih tumora. Međutim, molekularni mehanizmi putem kojih heterozigotne mutacije RPs uzrokuju bolesti najvećim dijelom su nepoznati. Proizveli smo genetički modificiranog miša u kojemu se gen za RpS6 može izrezati pomoću rekombinaze Cre. Upotrebom toga životinjskog modela dokazano je da heterozigotnost za RpS6 u stanicama koštane srži uzrokuje patološke promjene koje su slične premalignom sindromu 5q- u ljudi. U pripremi za ovaj projekt HRZZ dokazali smo da heterozigotnost za RpS6 u fibroblastima iz embrija miša (MEF) značajno doprinosi njihovoj zloćudnoj preobrazbi. Temeljem tih rezultata postavljamo hipotezu da heterozigotnost za RpS6 uzrokuje molekularne promjene koje potiču zloćudnu preobrazbu normalnih stanica. Predlažemo sljedeće specifične ciljeve istraživanja koji će omogućiti testiranje te hipoteze:1. Proizvesti MEF-ove u kojima se može uvjetno odstraniti jedan alel gena za RpS6 i gen p53 2. Testirati onkogeni potencijal MEF-ova heterozigotnih za RpS6 3. Odrediti učinak heterozigotnosti za RpS6 gen i gubitka gena p53 na morfološka obilježja jezgrice i njene funkcije, stabilnost genoma, strukturu kromatina i globalnu regulaciju izražaja gena.4. Identificirati mRNA čija je translacija na ribosomima poremećena.Ovaj prijedlog projekta pravovremen je i inovativan. Predloženo istraživanje razjasnit će zagonetku kako sniženi izražaj RP, ključnih sastavnica staničnih strojeva koji omogućuju rast stanice, uzrokuju zloćudne tumore. Osim toga, projekt će unaprijediti istraživački kapacitet, obrazovanje mladih znanstvenika i podići razinu kvalitete istraživanja u Hrvatskoj putem suradnje s vrhunskim svjetskim istraživačima.]]></summary_hr><summary_en><![CDATA[An abundance of evidence from animal models and human disease has shown that inherited and acquired heterozygous mutations of a number of ribosomal proteins can lead to cancer development as well as a variety of other diseases. However, the underlying molecular mechanisms are still largely unknown. We have previously generated a mouse model in which one allele of the RpS6 gene can be conditionally deleted. By employing this model it was shown that RpS6 heterozygosity in bone marrow recapitulates key features of a premalignant condition in humans, the 5q- syndrome. Our preliminary results have shown that RpS6 heterozygous mouse embryonic fibroblasts (MEFs) in the absence of p53 show much greater tumorigenicity than p53 null MEFs, further supporting the view that RpS6 heterozygosity is an oncogenic event. Thus, we hypothesize that RpS6 heterozygosity may lead to molecular alterations that could facilitate malignant transformation. In order to test this hypothesis, we propose the following specific aims:1. Generate conditional MEFs for inducible deletion of one RpS6 allele alone or in combination with p53 gene2. Assess tumorigenic potential of RpS6 heterozygosity3. Determine the impact of RpS6 heterozygosity and p53 loss on nucleolar structure and function, maintenance of genome stability, chromatin structure and global regulation of gene transcription.4. Characterize the mRNA translation landscape of RpS6 heterozygous MEFs.This is innovative and timely proposal. Our studies will elucidate a long standing conundrum, how hypomorphic mutations in RP genes, essential components of the cell’s growth machinery can lead to cancer. The project should positively impact the research capacity, education and science in Croatia via scientific cooperation with world-renowned scientists abroad.]]></summary_en></project><project>
<id>4284</id><title_hr><![CDATA[Frakcionalni analogni i mješoviti sustavi obrade signala]]></title_hr><title_en><![CDATA[Fractional analog and mixed systems for signal processing]]></title_en><user_id>6508</user_id><user_firstLast_name>Dražen Jurišić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-1307</code><acronim><![CDATA[FractalAnalogFilters]]></acronim><duration>24.02.2017 - 31.07.2021</duration><status>Završio</status><financ_value>102.063,84 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>1391, 13521, 7457, 3773, 21276, 19032, 24356, </team_members_id><team_members_names><![CDATA[Vesna Županović, Boško Mrković, Neven Mijat, Domagoj Vlah, Edi Emanović, Marko Šprem, Tomislav Jelkovic, ]]></team_members_names><keywords_hr><![CDATA[Analogni i mješoviti krugovi, Aktivni električni filtri, Analogno sučelje, Cadence, PSpice]]></keywords_hr><keywords_en><![CDATA[Analog and mixed circuits, Active electrical filters, Analog front end,  Cadence, PSpice]]></keywords_en><summary_hr><![CDATA[U predloženom projektu će se istraživati nove metode projektiranja vremenski kontinuiranih aktivnih analognih filtara necjelobrojnog (frakcionalnog) reda za analogno sučelje u komunikacijskim sustavima. Do sada su takvi sustavi bili cjelobrojnog reda, a u ovom projektu će se izvršiti poopćavanje na necjelobrojni red. U najnovijim publikacijama dokazano je da su takve metode poželjne, ali u mnogim primjenama postoje ograničenja zbog izvedivosti frakcionalnih komponenata koji nisu još u komercijalnoj uporabi. Osim problema u proizvodnji frakcionalnih komponenata postoje i neriješeni matematički problemi kao što su analiza osjetljivosti, šuma, te stabilnosti necjelobrojnih sustava. U integriranoj realizaciji se ti problemi posebno uočavaju (visoke osjetljivosti na tolerancije komponenata, nestabilnost zbog parazita) i pozivaju na nove, nekonvencionalne i kreativne tehnike realizacije. Posebno ćemo se u istraživanju usredotočiti na analogni dio mješovitih elektroničkih sklopova, kao dio &#39;analognog sučelja&#39; prema vanjskom analognom svijetu. Pokazati ćemo da se primjenom teorije električnih krugova i linija mogu postići razna predložena poboljšanja. Istraživanja u početku će biti cjelobrojna, a zatim ćemo se koristiti frakcionalnim računom kako bi dobili što veću fleksibilnost i dodatni stupanj slobode u projektiranju. Pomoću teorije fraktala predložiti ćemo novu Besselovu filtarsku aproksimaciju. Kao rezultat projekta, uz navedena nova teoretska dostignuća, dva integrirana kruga koja služe za verifikaciju teorije, realizirat će se u tipičnoj CMOS 0,18um ili 0,35um tehnologiji za koju imamo podršku na FER-u. Ovaj projekt je važan jer unaprjeđuje analogne električne filtre, koji su kasnili u razvoju. Projekt također nudi mogućnost znanstvenog usavršavanja mladih znanstvenika u Hrvatskoj, jer su doktorski studenti i postdoktorski istraživači predviđeni kao suradnici na projektu.  Također je primjenjiv u industriji.]]></summary_hr><summary_en><![CDATA[The proposed project will explore new methods for design of continuous time analog filters of non-integer (fractional) order for analog interface in communication systems. Until now, such systems were of integer order, and in this project the generalization to the non-integer order will be done. In recent publications it has been proven that such methods are desirable, but in many applications, there are limitations due to the feasibility of fractional components that are not yet in commercial use. In addition to the problems in the production of fractional components there are unsolved mathematical problems such as sensitivity analysis, noise and stability of non-integer systems. In the integrated implementation these problems are especially observed (high sensitivity to components tolerances, instability due to parasitic components) and are calling for new, unconventional and creative techniques of realization. In particular we will focus our research on analog part of mixed electronic circuits, which is a part of the &#39;analog interface&#39; to the outside analog world. We will show that the application of the theory of electrical circuits and lines can achieve a variety of proposed improvements. Research in the beginning will be of integer order, and afterwards fractional for high flexibility and additional degree of design freedom. Using the theory of fractals we propose a new Bessel filter approximation. As a result of the project, with new theoretical achievements, two integrated circuits that are used for verification of the theory will be realized in a typical CMOS 0,18um or 0,35um technology for which we have the support of the FER. This project is important because it improves the analog electrical filters that were late in development. The project also offers the possibility of training young scientists in Croatia, because they are predicted as collaborators on this project as doctoral students and postdoctoral researchers. It is applicable for industry, too.]]></summary_en></project><project>
<id>4286</id><title_hr><![CDATA[Modeliranje mentalne gramatike hrvatskoga: ograničenja informacijske strukture]]></title_hr><title_en><![CDATA[The Building Blocks of Croatian Mental Grammar: Constraints of Information Structure]]></title_en><user_id>12893</user_id><user_firstLast_name>Anita Peti-Stantić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-1210</code><acronim><![CDATA[MEGAHR/MEGACRO]]></acronim><duration>10.03.2017 - 09.10.2021</duration><status>Završio</status><financ_value>73.793,88 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filologija, </scie_field_hr><scie_field_en>Philology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>3451, 12761, 4516, 7143, 7769, 19536, 6644, 24278, 25299, </team_members_id><team_members_names><![CDATA[Mateusz-Milan Stanojević, Jelena Tušek, Mirjana Tonković, Nikola Ljubešić, Gordana Keresteš, Jana Willer-Gold, Maja Anđel, Irina Masnikosa, Vedrana Gnjidić, ]]></team_members_names><keywords_hr><![CDATA[mentalna gramatika, informacijska struktura, računalno modeliranje, psiholingvistika, paralelna arhitektura, jezična kompetencija]]></keywords_hr><keywords_en><![CDATA[mental grammar, information structure, computational modeling, psycholinguistics, parallel architecture, language competence]]></keywords_en><summary_hr><![CDATA[Osnovni je cilj projekta Modeliranje mentalne gramatike hrvatskoga: ograničenja informacijske strukture odrediti gradivne sastavnice informacijske strukture mentalne gramatike hrvatskoga. Na temelju korpusnog i psiholingvističkog pristupa istražit ćemo načine procesiranja morfosintaktičkoga i semantičkoga slaganja konkretnih i/ili apstraktnih leksičkih jedinica u koordiniranim i eliptičnim strukturama, kao i načine procesiranja informacijske strukture rečenice s obzirom na smještaj klitika. Na temelju toga ćemo odrediti skup nužnih, univerzalnih kao i jezičnospecifičnih obrazaca koji određuju informacijsku strukturu hrvatskoga, na morfosintaktničkoj i na semantičkoj razini. Usredotočit ćemo se na lokalna (linearna) i globalna (hijerarhijska) ograničenja procesiranja u mentalnoj gramatici hrvatskoga. Teorijske posljedice takvoga pristupa vidjet će se u mogućnosti razvijanja modela jezičnoga procesiranja, kao i za određivanje i uspostavljanje veza između globalnih i lokalnih gradivnih elemenata mentalne gramatike hrvatskoga. Na praktičnoj će razini projekt kroz kurikularnu obnovu pridonijeti poboljšanju produktivne jezične kompetencije u okvirima obrazovnog sustava. Kako bismo ostvarili ove ciljeve, provest ćemo tri vrste aktivnosti: 1) na temelju korpusa hrWaC uspostavit ćemo korelaciju između kategorija konkretnosti i predočivosti za 3000 leksičkih jedinica kao i za skup gramatičkih jedinica (zamjeničkih i glagolskih klitika); 2) uspostavit ćemo odnos između konretnosti i slaganja (s obzirom na rod, elipsu i smještaj klitika); 3) odredit ćemo specifične obrascie potrebne za izgradnju komunikacijski učinkovitih mreža riječi i gramatičkih struktura u hrvatskom obrazovnom sustavu.Metodološka inovativnost istraživanja ogleda se u povezivanju teorijski informiranog kvalitativnog i kvantitativnog psiholingvistički relevantnog istraživanja koje će omogućiti uspostavu prediktivne leksičke analize na razini korpusa, kao i na razini gramatičkih obrazaca mentalne gramatike.]]></summary_hr><summary_en><![CDATA[The goal of the project The Building Blocks of Croatian Mental Grammar: Constraints of Information Structure is to determine the building blocks of the information structure of Croatian mental grammar. Specifically, based on corpus and psycholinguistic research, we will look into how speakers process morphosyntactic and semantic agreement of concrete and/or abstract lexical items in coordinated constructions and elliptical conditions, as well as how they process sentence information structure with regard to complex clitic cluster positioning. Thus, we will determine a set of necessary, universal and language-specific patterns that represent the requirements determining the information structure in Croatian, both on the morphosyntactic and the semantic level. We are predominantly interested in local (linear) and global (hierarchical) processing constraints within the mental grammar of Croatian. Our approach will have theoretical consequences for developing a model of language processing, as well as identifying and correlating global and local building blocks of mental grammar of Croatian. On the practical level, we seek to improve the productive linguistic competence of pupils in the education system. This will be operationalized through three main activities: (1) psycholinguistically establishing a correlation between concreteness and imageability for a set of high and low frequency lexical and grammatical items (clitics) based on corpus data; (2) psycholinguistically establishing the relationship between concreteness and agreement (in gender, ellipsis and clitic cluster positioning); (3) establishing language-specific patterns for building effective word and grammar webs within the educational system. Methodological novelty is reflected in connecting a theoretically-based qualitative and quantitative psycholinguistic research with a corpus study, which will enable the establishment of a predictive lexical analysis, as well as grammatical patterns in mental grammar.]]></summary_en></project><project>
<id>4287</id><title_hr><![CDATA[Kolektivni efekti, tunelirajući i topološki transport u novim nanospojevima]]></title_hr><title_en><![CDATA[Collective effects, tunnelling and topological transport in novel nanojunctions]]></title_en><user_id>6910</user_id><user_firstLast_name>Danko Radić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-2289</code><acronim><![CDATA[C3TiNN]]></acronim><duration>15.03.2017 - 14.03.2022</duration><status>Završio</status><financ_value>126.318,93 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>13440, 2752, 19805, 25070, 4962, 864989, </team_members_id><team_members_names><![CDATA[Anatoliy Kadygrobov, Emil Tafra, Nina Marković, Petra Grozić, Zoran Rukelj, Barbara Keran, ]]></team_members_names><keywords_hr><![CDATA[magnetsko polje, magnetski proboj, sintetičko baždarno polje, val gustoće, kvantne oscilacije, NEMS, tunelirajući transport, topološki transport]]></keywords_hr><keywords_en><![CDATA[magnetic field, magnetic breakdown, synthetic gauge field, density wave, quantum oscillations, NEMS, tunneling transport, topological transport]]></keywords_en><summary_hr><![CDATA[Prvi cilj ovog projekta je formulirati teorijski pristup za istraživanje novih značajki pod utjecajem magnetskog polja i drugih baždarnih polja, induciranim npr. deformacijom rešetke, na kolektivna, strukturna, magnetotransportna i elektromehanička svojstava materijala reducirane dimenzije, odnosno 2D i kvazi-2D sustava poput grafena, spojeva baziranih na grafenu i nekih hi-Tc kuprata. Želimo istražiti posebnu ulogu magnetskog proboja u grafenu i sličnim sustavima u kojima elektron-elektron interakcija nije naglašena &#39;&#39;ugnježđenjem&#39;&#39; Fermijeve plohe. Također, u posebnom fokusu je jedinstveno svojstvo grafenskog sustava s Dirakovskom elektronskom disperzijom: nastank snažnih pseudomagnetskih polja zbog mehaničke deformacije rešetke. Naše preliminarne estimacije ukazuju mogućnost nastanka novog tipa osnovnog stanja - val gustoće induciran magnetskim probojem zbog sinttičkog magnetskog polja što možda objašnjava opaženi vala gustoće naboja u interkaliranom grafitu CaC6. Također, želimo istražiti pojavu kvantnih oscilacija u magnetotransportu, fundamentalno utjecanih magnetskim probojem, opaženih u grafenskim sustavima i hi-Tc kupratima. Nadalje, istražit ćemo nanoelektromehanički sustav baziran na grafenu i &#39;&#39;spin-gate&#39;&#39; mehanizmu u cilju nalaženja parametarskog prostora za nastanak samo-ekscitiranih oscilacija zbog magnetomotornog vezanja elektronskog i mehaničkog podsustava uz poseban fokus na ulogu sintetičkih polja. Drugi cilj je eksperimentalna realizacija tj. dizajn i fabrikacija uređaja na nanoskali koji se temelji na spinskim efektima induciranim magnetskim poljem. Također, istražit ćemo nova kolektivna stanja kombiniranjem materijala s različitim parametrima uređenja ili topološki zaštićenim stanjima. Pored fabrikacije obavit ćemo mjerenje kompletne magnetotransportne karakteristike.]]></summary_hr><summary_en><![CDATA[The first goal of this project is to formulate a theoretical approach for novel features under influence of magnetic field and other gauge fields, introduced by e.g. deformation of the lattice, on collective, structural, magneto-transport and electromechanical properties of materials with reduced dimension, namely of 2D and quasi-2D systems like graphene, graphene-based compounds and some high-Tc cuprates. We want to address the special role of magnetic breakdown to collective properties in the graphene-like systems in which electron-electron interaction is not enhanced by the &#39;&#39;nesting&#39;&#39; of the Fermi surface. Also we put a special focus on unique feature of grapehene-like system with Dirac-like electron dispersion: the onset of strong pseudomagnetic fields due to mechanical deformation of lattice. Our preliminary estimations indicate the possibility of new type of ground state - magnetic breakdown-induced density wave, driven by the synthetic magnetic field, possibly explaining the recently observed charge density wave in intercalated graphite CaC6. Also, we want to address the onset of quantum oscillations in magnetotransport, also fundamentally influenced by magnetic breakdown, observed in graphene-based systems and high-Tc cuprates. Furthermore, the graphene-based nanoelectromechanical systems based on spin-gate mechanism will be investigated in order to find parameter space for onset of self-excited oscillations due to magnetomotive coupling of electronic and mechanical subsystem with special focus on the role od synthetic fields. The second goal is experimental realization i.e. design and fabrication of nanoscale devices that utilize and investigate the magnetic field-driven spin-dependent phenomena. We will also explore creating novel collective states by combining materials with different order parameters or topologically protected states. Besides fabrication the complete magnetotransport characteristic will be measured.]]></summary_en></project><project>
<id>4290</id><title_hr><![CDATA[Molekularni biljezi vulnerabilnosti, adaptacije i plastičnosti neurona u akutnoj i kroničnoj ozljedi mozga]]></title_hr><title_en><![CDATA[Molecular markers of neuronal vulnerability, adaptation and plasticity in acute and chronic brain lesion]]></title_en><user_id>12600</user_id><user_firstLast_name>Svjetlana Kalanj Bognar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-8636</code><acronim><![CDATA[NeuroReact]]></acronim><duration>01.06.2017 - 31.03.2022</duration><status>Završio</status><financ_value>127.473,62 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo, Prirodne znanosti, </scie_area_hr><scie_area_en>Biomedicine and health sciences, Natural sciences, </scie_area_en><scie_field_hr>Temeljne medicinske znanosti, Kemija, Biologija, Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, Chemistry, Biology, Clinical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>12492, 13292, 13131, 5255, 7088, 19823, 19405, 7574, 19043, 19532, 23338, 26530, </team_members_id><team_members_names><![CDATA[Kristina Mlinac Jerković, Željka Vukelić, Dragana Fabris, Aleksandra Dugandžić, Pero Hrabač, Ivana  Rosenzweig, Rodrigo Herrera Molina, Tomislav Sajko, Katarina Ilić, Zamfir Alina, Mario Stojanović, Borna Puljko, ]]></team_members_names><keywords_hr><![CDATA[selektivna vulnerabilnost neurona, hipokampus, mali mozak, glikolipidom, plastičnost, neurodegeneracija]]></keywords_hr><keywords_en><![CDATA[selective neuronal vulnerability, hippocampus, cerebellum, glycolipidome, plasticity, neurodegeneration]]></keywords_en><summary_hr><![CDATA[Više od 165 milijuna ljudi u Europi boluje od poremećaja koji zahvaćaju živčani sustav. Izrazito opterećenje za bolesnika i zdravstveni sustav predstavljaju bolesti kojima je zajednička neurodegeneracija. Neuroni pokazuju selektivnu vulnerabilnost, a intrigantna je razlika u odgovoru na raznovrsne nokse između velikog i malog mozga. Naša je hipoteza da različiti tipovi stanica u mozgu sadrže prepoznatljiv molekularni „potpis“ koji ih čini više ili manje osjetljivima i koji sudjeluje u odgovoru na patološki proces. Cilj projekta je utvrditi u kolikoj mjeri su za selektivnu vulnerabilnost neurona odgovorni zajednički učinci ekspresije određenih proteina i njihovog lipidnog miljea, odnosno postoje li specifične promjene sastava i ekspresije membranskih glikolipida i proteina koje se mogu povezati s patogenezom neurodegeneracije u stanjima akutne i kronične ozljede mozga. Fokusirat ćemo se na analizu neurona hipokampusa i malog mozga u stanjima hiperekscitabilnosti, hipoksične lezije i Alzheimerovoj bolesti. U istraživanju će biti korišteni ljudski uzorci, tkivo mišjih modela i stanični model, čiji će specifični glikolipidomski profili biti povezani s rezultatima transkriptomske, proteomske, elektrofiziološke i morfološke analize. Projekt je nastavak naših istraživanja koja su dokazala: promjene sastava i metabolizma gangliozida u Alzheimerovoj bolesti u mozgu i perifernim tkivima; utjecaj sastava moždanih gangliozida na ekspresiju membranskih proteina uključenih u sinaptičku plastičnost i transport iona, u mišjem modelu čijim fenotipom dominira degeneracija aksona i sklonost konvulzijama. U ovoj studiji ćemo usporediti ekspresiju glikolipida i izabranih proteina u dvije regije mozga s različitim odgovorom na neurodegeneraciju, stoga očekujemo da će istraživanje olakšati prepoznavanje specifičnih molekularnih biljega vulnerabilnosti i adaptacije neurona. Hipotetski je moguće modulirati aktivnost molekula-biljega i pospješiti funkcionalnu prilagodbu tkiva na ozljedu.  ]]></summary_hr><summary_en><![CDATA[Nervous system disorders affect more than 165 million people in Europe. Diseases sharing neurodegeneration as a common pathological feature present a particularly big burden for patients and public health. Neurons are selectively vulnerable and there is intriguing difference between cerebral and cerebellar neurons responding to pathological stimuli. We hypothesize that different neuronal types contain recognizable molecular “signature” making them more or less susceptible and which is involved in tissue response to lesion. The aim of the project is to estimate combined effects of specific membrane proteins expression and their lipid environment on selective neuronal vulnerability, i.e. to determine whether specific changes in membrane glycolipid and protein composition and expression may be related to neurodegenerative pathogenic events. We will focus on the analysis of hippocampal and cerebellar neurons affected by hyperexcitability, hypoxia and Alzheimer’s disease. Glycolipidomic profile of selected regions derived from human and mouse models brain and cellular model will be associated with results of detailed transcriptomic, proteomic, electrophysiological and morphological analysis. Project is based on our previous research showing: changes of ganglioside composition and metabolism in brain and peripheral tissues in Alzheimer’s disease; influence of brain ganglioside composition on expression of membrane proteins involved in synaptic plasticity and ion transport in mouse model with phenotype characterized by axonal degeneration and susceptibility to convulsions. In this study, we will compare the expression of glycolipids and selected proteins in two brain regions responding/reacting differently to neurodegeneration. We expect that such an approach will enable recognition of specific molecular markers of neuronal vulnerability and adaptation. Hypothetically, modulating the activity of these molecular markers may contribute to functional tissue adaptation.]]></summary_en></project><project>
<id>4294</id><title_hr><![CDATA[Fizika mnogočestičnih sustava - iskorištavanje svijeta kompleksnosti]]></title_hr><title_en><![CDATA[The physics of many body systems – exploiting the world of complexity]]></title_en><user_id>4336</user_id><user_firstLast_name>Osor  Slaven Barišić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-7258</code><acronim><![CDATA[COMPLEX_ORBIS]]></acronim><duration>01.03.2017 - 31.10.2021</duration><status>Završio</status><financ_value>126.326,38 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut za fiziku]]></institution_hr><institution_en><![CDATA[Institute of Physics in Zagreb]]></institution_en><team_members_id>3457, 4814, 6532, 4380, 25109, 25108, 28808, 855336, 855341, </team_members_id><team_members_names><![CDATA[Katarina Uzelac, Zvonko Glumac, Ivan Balog, Eduard  Tutiš, Yuki Utsumi Boucher, Juraj Krsnik, Naveen Singh  Dhami, Sudhakar  Pandey, Lucija Nora Farkaš, ]]></team_members_names><keywords_hr><![CDATA[jaka međudjelovanja, nered, neravnotežna dinamika, kompleksni sustavi, izranjajuće pojave]]></keywords_hr><keywords_en><![CDATA[strong interactions, disorder, nonequlibrium dynamics, complex systems, emerging phenomena]]></keywords_en><summary_hr><![CDATA[Kompleksni sustavi karakterizirani su izranjajućim pojavama koje se u hijerarhiji skala pojavljuju vrlo daleko od onih skala koje karakteriziraju međuodnose između pojedinačnih sastavnica tih sustava. Zato takve pojave, vrlo različitih uzroka, konstantno privlače pažnju znanstvene zajednice. Bez obzira na inherentnu raznolikost, različite teme vezane za fiziku kompleksnih sustava dijele neke zajedničke koncepte i principe. Razumijevanje takvog fizikalnog bogatstva zahtijeva razvoj integrativnog teorijskog pristupa, sposobnog  tretirati probleme istovremeno preko različitih polja istraživanja. Osnovna ideja ovoga projekta je ostvarivanje široke strategije istraživanja, birajući probleme koji su izrazito aktualni unutar međunarodnih istraživanja, uz istovremeno održavanje bliske veze s eksperimentalnim rezultatima.Projekt se bavi izranjajućim pojavama u mnogočestičnim sustavima karakteriziranim jakim međudjelovanjem, neredom i/ili izvanravnotežnim stanjem. Predmeti predloženog istraživanja kreću se od specifičnih materijala od posebnog interesa u polju kondenzirane materije, do bioloških sustava, čije se funkcije u prirodnom okruženju u pravilu ostvaruju u izvanravnotežnim stanjima. Projekt je organiziran u tri radna paketa (WP), pri čemu se svaki od njih usredotočuje na jednu od klasa mnogočestičnih sustava u kojima se opažaju izranjajuće pojave. To su sustavi s jakim međudjelovanja, sustavi s neredom i sustavi izvan ravnoteže. Svaki WP je organiziran je u različite zadaće, koje iako su specifične za određeni WP dijele ujedno i značajan stupanj komplementarnosti, osiguravajući koherentnost i međupovezanost između WP-ova.Osim specifičnih znanstvenih doprinosa, namjera projekta je omogućiti i značajnu konsolidaciju teorijskih istraživanja na Institutu za fiziku, uključujući poboljšano okruženje za mlade istraživače. Podrška HrZZ-a projektu je stoga od ključne važnosti za održanje međunarodne kompetitivnosti članova tima, kao i za otvaranje novih perspektiva. ]]></summary_hr><summary_en><![CDATA[Complex systems are characterized by phenomena emerging in the hierarchy of scales far from those describing the numerous individual components. Such phenomena, which have a variety of origins, have repeatedly attracted the attention of the scientific community. Irrespective of the inherent diversity, some common concepts and principles are shared across different topics. Uncovering and understanding this richness requires the development of an integrative theoretical approach, capable of dealing with many-body problems across different fields. In this light, the main purpose of the present project is to enforce such a broad strategy by choosing problems that are highly relevant in current international research endeavors, while simultaneously maintaining a close connection with experimental results.The project addresses phenomena that emerge in systems characterized by strong interactions, disorder and/or the absence of equilibrium. The objects of the proposed research range from specific materials, the investigation of which is on the forefront of condensed matter research, to biological systems, functioning in their natural environment as physical systems far from equilibrium. The project is organized into work packages (WPs), each of which focuses on one important aspect of many-body systems exhibiting emergent phenomena. These are strong interactions, disorder and out-of-equilibrium dynamics. Each WP is organized around a series of different tasks, which, while WP-specific, share a significant degree of complementarity, ensuring coherence and interconnectedness across the WPs. Besides specific scientific contributions, the project aims to provide a significant consolidation of theoretical investigations at the Institute of Physics, including an improved environment for young researchers. The HrZZ’s support of the project is therefore of crucial importance for maintaining the international competitiveness of team members and for future perspectives.]]></summary_en></project><project>
<id>4299</id><title_hr><![CDATA[Geološki i seizmološki aspekti geodinamike Kvarnera - razotkrivanje kvarnerskog rasjeda]]></title_hr><title_en><![CDATA[Geological and seismological aspects of geodynamics in Kvarner area - unveiling of the Kvarner fault]]></title_en><user_id>13721</user_id><user_firstLast_name>Tvrtko Korbar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-1854</code><acronim><![CDATA[GEOSEKVA]]></acronim><duration>20.03.2017 - 19.09.2021</duration><status>Završio</status><financ_value>130.532,88 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Geologija, Geofizika, </scie_field_hr><scie_field_en>Geology, Geophysics, </scie_field_en><institution_hr><![CDATA[Hrvatski geološki institut]]></institution_hr><institution_en><![CDATA[Croatian Geological Survey]]></institution_en><team_members_id>13023, 13024, 19182, 19285, 19181, 6839, 17774, 19577, 3963, 1343, 40, 12912, 19648, 15919, 19298, 24305, 26640, 11151, </team_members_id><team_members_names><![CDATA[Ladislav  Fuček, Damir Palenik, Stanislav Bergant, Nikola Belić, Marko Špelić, Ozren Hasan, Dea Brunović, Pavle Ferić, Lara Wacha, Maša Surić, Snježana Markušić, Tomislav Fiket, Anna Del Ben, Vanja Kastelic, Krešimir Petrinjak, Marko Budić, Ana Kamenski, Branko Kordić, ]]></team_members_names><keywords_hr><![CDATA[Kvarner, geološka karta, seimički profili, 3D modeli, tektonika, potresi, kvartar, seizmotektonika]]></keywords_hr><keywords_en><![CDATA[Kvarner, geological map, seismic lines, 3D models, tectonics, earthquakes, Quaternary, seismotectonic]]></keywords_en><summary_hr><![CDATA[Šire područje Kvarnera se urbanistički i infrastrukturno ubrzano razvija, što u kombinaciji s kompleksnom geološkom građom i geodinamikom tog prostora povećava ranjivost od geohazardnih događaja, a posljedično i rizik. Epicentralno područje Rijeke obilježava pojava učestalih i relativno blagih potresa uz sporadičnu pojavu umjerenih i jakih potresa, koji su prema povijesnim podatcima uzrokovali i znatnija lokalna razaranja. Vjerojatni uzrok tih potresa je desno horizontalno kretanje duž jedne od glavnih rasjednih zona dinaridskog pružanja, koja je vjerojatno isprekidana još uvijek nejasno definiranom zonom poprečnih kvarnerskih rasjeda, što uz pretpostavljeno gravitacijsko klizanje starijih dinaridskih navlaka, moguće rezultira kompleksnim transpresijsko-transtenzijskim režimom u području Kvarnera. S ciljem što kvalitetnije procjene mehanizama potresa, nužni su geološki 3D modeli izrađeni na temelju suvremenih formacijskih (litostratigrafskih) karata, bušotinskih podataka, te interpretiranih seizmičkih profila. Neotektonika se može detektirati putem analize najmlađih naslaga iz plitkog podmorja (geo-akustična snimanja), daljinskih i izravnih istraživanja geomorfoloških formi te putem (re)interpretacije i datiranja kvartarnih naslaga na kopnu. Objedinjavanjem svih navedenih podataka u seizmotektonski model napravila bi se kvalitetna podloga za daljnja interdisciplinarna istraživanja i integraciju novih geoloških i seizmoloških podataka te uključivanje geodetski definiranih pomaka, s ciljem izrade relevantnog geodinamskog modela.]]></summary_hr><summary_en><![CDATA[The wider area of Kvarner has rapid urbanistic and infrastructural growth that, concerning the complex geological structure of this area, increases vulnerability of geohazard events and the risk. Rijeka epicentral area is known for the frequent occurrence of relatively weak earthquakes and occasional occurrence of moderate or large earthquakes, which, according to historical documents, caused locally very strong damage. The probable cause of the earthquakes is the dextral horizontal movement along one of the major fault zones with a Dinaridic strike, that is probably fragmented by a still inadequately defined system of transversal Kvarner faults, which in combination with the assumed gravitational sliding of early orogenic thin-skinned tectonic cover, probably resulted with a very complex transpressional-transtensional regime in the Kvarner region. With the aim to improve the interpretation of the earthquake mechanisms, there is a growing need for 3D geological models based on modern lithostratigraphic maps, borehole data, and interpreted seismic lines. Neotectonics can be detected by analyses of the youngest deposits on the shallow subbottom (geo-acoustical method), by remote and direct study of selected geomorphological features, and by (re)interpretation and dating of Quaternary deposits on land. Compilling the data in the integrated seismotectonic model would be a quality base for the next step, which would include further interdisciplinary research, i.e. integration of more detailed geological and seismological, as well as geodetic data, with the aim to build a relevant geodynamic model of the Kvarner region.]]></summary_en></project><project>
<id>4304</id><title_hr><![CDATA[Mikrosatelitna nestabilnost (MSI i EMAST) u molekularnom profiliranju sporadičnih karcinoma debelog crijeva]]></title_hr><title_en><![CDATA[Microsatellite instability (MSI and EMAST) in molecular profiling of sporadic colon cancer]]></title_en><user_id>12621</user_id><user_firstLast_name>Sanja Kapitanović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-1430</code><acronim><![CDATA[MSIandEMASTinCRC]]></acronim><duration>15.05.2017 - 14.01.2022</duration><status>Završio</status><financ_value>131.780,48 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>12624, 12651, 13128, 12693, 5103, 19360, 5467, 13140, 20089, 6515, 12941, 12988, 13124, 25005, 26763, 19670, </team_members_id><team_members_names><![CDATA[Tamara Čačev, Tina Catela Ivković, Emilija  Zapletal, Tanja Matijević Glavan, Gorana Aralica, Arijana Pačić, Leonardo Patrlj, Božo Lončar, Robert Kliček, Mislav  Rakić, Anita Škrtić, Mirko Poljak, Senka Radošević, Kristina Vuković, Anamarija Salar, Sonja Marinović, ]]></team_members_names><keywords_hr><![CDATA[karcinom debelog crijeva, mikrosatelitna nestabilnost, MSI, EMAST, NLRP3, molekularno profiliranje]]></keywords_hr><keywords_en><![CDATA[colon cancer, microsatellite instability, MSI, EMAST, NLRP3, molecular profiling]]></keywords_en><summary_hr><![CDATA[Zloćudni tumori predstavljaju jedan od vodećih zdravstvenih problema u svijetu. Karcinom debelog crijeva je jedan od najčešćih zloćudnih tumora i jedan od vodećih uzroka smrti od raka u zemljama razvijenog svijeta. Najveći broj karcinoma debelog crijeva javlja se u sporadičnom obliku, a nastaje kao posljedica stupnjevitog procesa tijekom kojeg kao posljedica stečenih mutacija nastaje zloćudni invazivni tumor. Poznato je da mikrosatelitna nestabilnost (MSI) kao i mikroRNA (miRNA) koje reguliraju ekspresiju gena također imaju ulogu u tumorigenezi ovog tumora. EMAST (od engl. Elevated Microsatellite Alterations at Selected Tetranucleotide repeats) je oblik mikrosatelitne nestabilnosti čiji je nastanak potaknut upalom, a koji utječe na napredovanje tumorske bolesti. Rezultati naših prijašnjih istraživanja ukazuju na ulogu upalnih citokina u tumorigenezi karcinoma debelog crijeva. Ovim ćemo projektom istraživanja proširiti na inflamasom NLRP3 za kojeg je pokazano da utječe na tumorigenezu s upalom povezanih gastrointestinalnih tumora. Cilj ovog projekta je ispitati mikrosatelitnu nestabilnost tipa MSI i EMAST u sporadičnim karcinomima debelog crijeva te rezultate korelirati s kliničko-patološkim karakteristikama tumora i oboljelih. Tumore ćemo molekularno profilirati s obzirom na učestalost i distribuciju MSI i EMAST te mutacija u genima koji kodiraju molekule ključnih signalnih puteva (KRAS/BRAF, p53). Rezultati će također biti korelirani s naslijeđenim genetskim profilima oboljelih temeljenim na polimorfizmima inflamasoma NLRP3 i citokina kao i s ekspresijom gena od interesa na razini mRNA, miRNA i proteina. Očekujemo da će rezultati istraživanja doprinjeti rasvjetljavanju molekularne osnove sporadičnih karcinoma debelog crijeva, te naći primjenu u praćenju i liječenju oboljelih.]]></summary_hr><summary_en><![CDATA[Cancer is one of the most important health issues of today and number of cancer cases is expected to increase in the future. Colon cancer is one of the most common cancers and the second leading cause of cancer death in the Western world. Most cases of colon cancer occur in sporadic form and follow the adenoma-carcinoma sequence. The development of the sporadic colon cancer is a result of the accumulation of sporadic mutations in many different genes, oncogenes, tumor suppressor genes as well as mismatch repair genes. It is known that microsatellite instability (MSI) as well as microRNAs (miRNAs) as regulators of gene expression also have a role in sporadic CRC tumorigenesis. Elevated microsatellite alterations at selected tetranucleotide repeats (EMAST) is a form of microsatellite instability that is initiated by inflammation and modulates colon cancer progression. The results of our previous study suggest the role of inflammatory cytokines in colon cancer tumorigenesis. In this project the research will be extended to NLRP3 inflammasome, a potent inducer of proinflammatory cytokines. The main goal of this project is to investigate MSI and EMAST microsatellite instability in sporadic colon cancer and to correlate the obtained results with clinico-pathological characteristics of tumors and patients. Tumors will be molecularly profiled with regard to frequency and distribution of MSI and EMAST and mutations in key cancer pathways (KRAS/BRAF, p53). In addition results will be correlated with patients’ inherited genetic profiles based on inflammasome NLRP3 and cytokine polymorphisms as well as expression of specific genes on mRNA, miRNA and protein level. We expect that our results will contribute to the elucidation of molecular basis of sporadic colon cancer, and be useful in patients’ surveillance and treatment.]]></summary_en></project><project>
<id>4305</id><title_hr><![CDATA[Preuređivanje memorije: Manipuliranje T-staničnom memorijom u svrhu unapređenja učinkovitosti cjepiva]]></title_hr><title_en><![CDATA[Rewriting memory; Manipulation of T cell memory to enhance vaccine efficiency]]></title_en><user_id>19051</user_id><user_firstLast_name>Felix Wensveen</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-8027</code><acronim><![CDATA[T-MEMORY]]></acronim><duration>01.07.2017 - 30.11.2021</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Medicine]]></institution_en><team_members_id>19737, 19748, 25630, 29106, </team_members_id><team_members_names><![CDATA[Marko Šestan, Inga Kavazović, Mia Krapić, Dora Gašparini, ]]></team_members_names><keywords_hr><![CDATA[T Stanična memorija, infekcija, rak, Eomes, T stanični receptor]]></keywords_hr><keywords_en><![CDATA[T cell memory, infection, cancer, Eomes, T cell receptor]]></keywords_en><summary_hr><![CDATA[Imunost posredovana CD8 T-limfocitima pruža nam zaštitu od brojnih patogena i tumora. Naivni repertoar limfocita T se sastoji od milijuna različitih klonova koji se međusobno razlikuju po specifičnosti svojih T-staničnih receptora. Prilikom infekcije, samo neki od klonova postaju dugovjeke memorijske stanice. Selekcijski proces odabira memorijskih klonova reguliran je ravnotežom između specifičnosti i raznolikosti kako bi se osigurao učinkovit sekundarni odgovor te mogućnost prepoznavanja istih, mutiranih antigena. Mehanizmi koji kontroliraju raznolikost memorije još uvijek nisu razjašnjeni. Naša grupa je prepoznala Eomes kao ključni transkripcijski čimbenik za formiranje memorije, no kako pojačana ekspresija Eomesa rezultira stvaranjem imunološke memorije je idalje nepoznato.	U ovom projektu, istražit ćemo utjecaj intenziteta signala i aktivacije T-staničnog receptora na formiranje memorije putem Eomes-a. Prvo ćemo ispitati kako razlike u jačini stimulacije utječu na kvantitativnu i kvalitativnu aktivaciju glavnih nizvodnih komponenti te način na koji se taj signal prevodi u određenu razinu ekspresije Eomes-a. Paralelno, proučavat ćemo i način na koji Eomes pretvara taj aktivirajući signal određene jačine u molekularni proces koji rezultira stvaranjem imunološke memorije. U trećoj fazi projekta utvrditi ćemo ključne čimbenike koji posreduju tim procesima. Još bitnije, usredotočit ćemo se na čimbenike koji mogu imati terapeutsku primjenu kako bi testirali učinkovitost specifičnog ciljanja tih molekula na unaprjeđenje antitumorskih i antivirusnih cjepiva.	Ovdje predstavljeni projektni prijedlog, osim iznimne inovativnosti, ima velike izglede za uspjeh budući da se temelji na velikoj količini preliminarnih rezultata. Uz to, jedna od ključnih prednosti je i naše dugogodišnje iskustvo i rad u području imunologije i istraživanja na životinjama. Stoga držimo da je ovaj projekt izvrsna investicija u hrvatsku akademsku zajednicu koja pomaže razvoju nove istraživačke grupe.]]></summary_hr><summary_en><![CDATA[CD8 T cell mediated immunity protects us against pathogens and cancer. The naive T cell pool consists of millions of clones, each one unique based on its T cell receptor (TCR). Upon infection, only a few of these clones are recruited to generate antigen-specific memory. Selection of memory clones is a trade-off between specificity and diversity to ensure both an efficient recall response and recognition of a sufficient number of targets. Mechanisms controlling memory diversity are largely unclear. Recently, we have identified the transcription factor Eomes as a key mediator of memory formation. How Eomes induction results in shaping of the memory cell pool is currently unknown.  	In this project, we will study the impact of activating T cell receptor signal intensity on memory formation via the transcription factor Eomes. First, we will investigate how TCR signal strength impacts the quality and quantity of activation of its main downstream components and how this translates into the activation of Eomes. In parallel, we will investigate how Eomes translates TCR-activating stimuli of a given strength in a molecular process that promotes memory formation. Using the combined information of these two lines of inquiry, we will identify and validate key factors that mediate these processes in the third phase of the project. Importantly, we will select for molecules that can be targeted by pharmacological means. Finally, we will test the potency of therapeutic intervention for the improvement of antiviral and anti-cancer vaccines. 	The proposal described here is both innovative, and has a high chance of success, since it is based on a large amount of preliminary data. This project builds on the strengths that our department has developed in the fields of immunology and animal research, while adding a fresh impulse of innovation. We therefore believe that this project is a solid investment in Croatian academia and aids in the development of a strong new research group. ]]></summary_en></project><project>
<id>4306</id><title_hr><![CDATA[Transformacija pepela iz drvene biomase u građevne kompozite s dodanom vrijednošću]]></title_hr><title_en><![CDATA[Transformation of Wood Biomass Ash into Resilient Construction Composites]]></title_en><user_id>3406</user_id><user_firstLast_name>Nina Štirmer</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-7701</code><acronim><![CDATA[TAREC2]]></acronim><duration>01.03.2017 - 28.02.2021</duration><status>Završio</status><financ_value>125.738,27 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Temeljne tehničke znanosti, Građevinarstvo, </scie_field_hr><scie_field_en>Basic engineering sciences, Civil engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Građevinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Civil Engineering]]></institution_en><team_members_id>4319, 5060, 7510, 3023, 19775, 20012, 19926, 1276, 19910, 7662, 3218, 21277, 24284, 25367, 17806, </team_members_id><team_members_names><![CDATA[Bojan Milovanović, Ana Baričević, Ivana Banjad Pečur, Neven Ukrainczyk, Eduardus Koenders, Virna Višković-Agušaj, Ivana Carević, Ivan Gabrijel, Velimir Šegon, Dubravka  Bjegović, Marija Jelčić Rukavina, Ivan Rimac, Karmen Kostanić Jurić, Jelena Šantek Bajto, Martina Grubor, ]]></team_members_names><keywords_hr><![CDATA[drvna biomasa, pepeo drvne biomase, mineralni kompozit, građevni proizvod, trajnost]]></keywords_hr><keywords_en><![CDATA[wood biomass, wood biomass ash, mineral composite, construction product, durability ]]></keywords_en><summary_hr><![CDATA[Energane na krutu i plinovitu biomasu predstavljaju jedan od najznačajnijih obnovljivih izvora energije u Europskoj uniji te se očekuje da će biti jedan od glavnih aktera pri dostizanju europskog plana za primjenu 20 % obnovljive energije u 2020. Uobičajeno se tijekom izgaranja 1 tone drvne biomase proizvede 5 MWh energije, ali i 20 – 50 kg pepela s dna peći kao i letećeg pepela. Predviđa se da će u EU-28 primjena energije iz energana na drvnu biomasu u budućnosti utjecati na proizvodnju približno 600 000 tona pepela. Trenutno se 70 % biopepela drvne biomase (PDB) odlaže, 20 % se nastoji primijeniti kao dodatak tlu u poljoprivredi i 10 % za ostale namjene. Strategijom energetskog razvoja RH određeno je da će se do 2020. godine koristiti 85 MWe iz biomase. U ožujku 2016. u Hrvatskoj je bilo 10 elektrana na biomasu, potpisano je 57 ugovora s Hrvatskim operatorom tržišta energije za gradnju elektrana u 2014. i 2015. godini (ukupno 95,342 MWe) te su zaprimljeni zahtjevi za odobrenje građenja dodatnih elektrana na biomasu snage 51,034 MWe.Cilj projekta TAREC2 je transformirati pepeo drvne biomase (PDB) u građevne kompozite s dodanom vrijednošću, kroz povezivanje tri ključna aktera s njihovim specifičnim interesima, u industrijsku simbiozu sa zajedničkim komplementarnim interesom, koji je u skladu s EU pravnim okvirima. Prvi akter je energetski sektor koji je korisnik drvne biomase kako bi proizveo energiju i kao rezultat toga proizvođač otpada drvne biomase. Drugi je građevinski sektor koji je korisnik sirovine koju proizvodi energetski sektor. Na kraju, znanost o materijalima služi kao poveznica između dva sektora koja osigurava podatke o sirovini i moguće primjene. Projekt uključuje i optimizaciju i modifikaciju cijelog lanca u tehnologiji procesa: dobivanje pepela iz energetskog procesa, karakterizaciju pepela, određivanje udjela sastojaka mješavine za građevinsku industriju i konačno demonstraciju razvijenog proizvoda i primjenu u građevinskoj industriji. ]]></summary_hr><summary_en><![CDATA[Solid and gaseous biomass fuelled power plants are the biggest source of renewable energy in the EU and are expected to make a key contribution to the 20% EU renewable energy target by 2020. Typically burning of 1 tons of forest biomass and wood waste generates 5 MWh of energy as well as 20 – 50 kg/t of bottom ash and fly ash. It is foreseen that the use of energy from wood biomass plants will lead in the future to the production of approximately 600 000 tons of biomass ash in the EU-28. Currently, 70% of wood biomass ash (WBA) is land filled, 20% tends to be used as a soil supplement in agriculture and 10% is used for miscellaneous application. Energy Sector Development Strategy of the Republic of Croatia determined that by 2020 use of energy from biomass should be 85 MW. In March 2016, there were 10 biomass power plants installed (total power 24.585 MWe). Additionally, 57 contracts were signed with Croatian energy market operator for construction of power plants during 2014 and 2015 (in total 95.342 MWe), while HROTE received requests for approval of construction of additional 51.034 MWe of biomass power plants.TAREC2 aims to transform waste wood biomass ash (WBA) into resilient construction composites, through incorporating three key actors, into an industrial symbiosis with joint complementary interest that is in accordance with EU legal framework. First key actor is the energy sector; user of wood biomass to produce energy and consequently producer of waste wood biomass ash. Another one is construction industry; user of raw material provided by the energy sector. Finally, materials science acts as a bridge between the two sectors, providing information on properties of obtained material and potential application. Project involves the optimization and the modification of the whole chain of process technology: ash obtaining and characterization, mixture proportioning and demonstration of the developed products and the applications in construction industry.]]></summary_en></project><project>
<id>4309</id><title_hr><![CDATA[Ekološki odziv sjevernog Jadrana na klimatske promjene i antropogeni učinak ]]></title_hr><title_en><![CDATA[Ecological response of northern Adriatic to climatic changes and anthropogenic impact]]></title_en><user_id>468</user_id><user_firstLast_name>Nastenjka Supić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-4764</code><acronim><![CDATA[EcoRENA]]></acronim><duration>27.03.2017 - 26.04.2022</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Geofizika, Kemija, Biologija, </scie_field_hr><scie_field_en>Geophysics, Chemistry, Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>3596, 467, 3277, 1020, 287, 3992, 1155, 4424, 429, 21415, 473, </team_members_id><team_members_names><![CDATA[Robert Precali, Tamara Đakovac, Davor Lučić, Mathieu Dutour Sikirić, Irena  Ciglenečki-Jušić, Jakica Njire, Jelena Dautović, Daniela Maric Pfannkuchen, Romina Kraus, Nataša Kužat, Paolo Paliaga, ]]></team_members_names><keywords_hr><![CDATA[klimatske promjene, antropogeni učinak, ekosustav, ekološki model, sjeverni Jadran]]></keywords_hr><keywords_en><![CDATA[climatic changes, anthropogenic impact, ecosystem, ecological model, northern Adriatic ]]></keywords_en><summary_hr><![CDATA[Zbog plitkoće i zatvorenosti  sjeverni je Jadran osobito osjetljiv na vanjske utjecaje, a pogotovo na promjene površinskih protoka vlage, energije i tvari. Prepoznat je kao sredozemna “vruća točka” klimatskih promjena jer se očekuje da će u budućnosti  biti pod bitno većim okolišnim pritiscima od većine drugih morskih sustava. Područje ima i širu veću važnost jer u njemu zimi nastaje gusta pridnena voda koja izlazi iz Jadrana i prenosi prenoseći hranjive soli i kisik u Sredozemno more. Zimski uvjeti sjevernog Jadrana su, kako je nedavno ustanovljeno, ključni za porast odnosno smanjenje populacije jedne od najkomercijalnijih jadranskih vrsta, inćuna.  Ekosustavu sjevernog Jadrana, između ostalog, često prijeti dolazak alohtonih vrsta, te neželjene i vrlo štetne pojave različitog intenziteta i trajanja (npr. pojava masovnih sluzavih nakupina ili izrazita potrošnja/potpuni nedostatak kisika u pridnenom sloju).  Oceanografska baza Centra za istraživanje mora iz Rovinja, koja sadrži dugogodišnji niz podataka (od 1920. g.) temelj je tzv. ekološkog empirijskog modela (EEM) koji objašnjava promjene u sustavu sjevernog Jadrana povezujući ih s promjenama dinamike vodenih masa i geostrofičkih struja, te površinskim i riječnim protocima. Upoznavanje odziva sjevernog Jadrana na različite pritiske, a osobito one koji su povezani s klimatskim promjenama i antropogenim učincima (npr. acidifikacija i eutrofikacija), cilj je ovog projekta.Prikupljanje novih podataka te korištenje numeričkog modela omogućit će proširenje i preispitivanje postojećih znanja o promjenama sjevernojadranskog ekosustava, a osobito priobalne zone. Takvo će istraživanje omogućiti i ispitivanje odziva ekosustava na predviđene promjene, a zbog širokog raspona ekoloških karakteristika sjevernog Jadrana, rezultati istraživanja bit će primjenjivi i na druge morske sustave.]]></summary_hr><summary_en><![CDATA[The northern Adriatic (NA) of a semi-enclosed nature and shallowness makes it highly reactive to the external forcing, in particular to variations of water, energy and matter fluxes at interfaces. Identified as the Mediterranean&#39;s climatic change „hotspot“ the region expects to undergo environmental impacts, considerably greater than in many other marine systems. The region deserves a special interest as an area of winter dense water formation which flows out of the Adriatic and brings nutrients and oxygen to the Mediterranean. Winter conditions in NA are crucial for increase/decrease in population of one of the most commercial fish species of the region, anchovy, as it has been recently established. Threats to the ecosystem are among others due to the intrusion of alohtone species, and undesirable phenomena of different intensity and duration (e. g. appearance of large mucilage aggregates or bottom anoxia events).  The Center for Marine Research-Rovinj&#39;s long-term  oceanographic data base (since 1920) was ground for development of an “empirical ecological model” (EEM) explaining changes in NA ecosystem relating them to changes in water masses dynamics and geostrophic currents, air-sea fluxes and riverine discharge. Response of the NA to various forcing and especially those related to climatic changes and anthropogenic impacts (acidification and eutrophication) is the aim of the EEM.Acquisition of new data and support of a numerical model will allow an extension and re-examination of existing knowledge on NA ecosystem changes, especially in the coastal zone. This research will enable to build scenarios of possible ecosystem reactions to predicted environmental changes, and due to a wider spectrum of ecological characteristics of NA finally can be applied in a wider sense to other marine systems. ]]></summary_en></project><project>
<id>4313</id><title_hr><![CDATA[Povećanje energetske učinkovitosti izmjenjivača topline]]></title_hr><title_en><![CDATA[Enhancement of the heat exchanger energy efficiency]]></title_en><user_id>5302</user_id><user_firstLast_name>Anica Trp</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-4095</code><acronim><![CDATA[HEXENER]]></acronim><duration>15.03.2017 - 01.09.2021</duration><status>Završio</status><financ_value>121.481,19 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, Temeljne tehničke znanosti, </scie_field_hr><scie_field_en>Mechnical engineering, Basic engineering sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Tehnički fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Engineering]]></institution_en><team_members_id>5298, 19388, 6050, 6289, 5146, 6950, 19407, 19392, 21279, 25384, </team_members_id><team_members_names><![CDATA[Kristian Lenić, Branimir Pavković, Vladimir Glažar, Igor Wolf, Paolo Blecich, Igor Bonefačić, Boris Delač, Mateo Kirinčić, Fran Torbarina, Josip Batista, ]]></team_members_names><keywords_hr><![CDATA[energetska učinkovitost, lamelni izmjenjivači topline, latentni spremnik topline, obnovljivi izvori energije, numeričke simulacije, eksperiment]]></keywords_hr><keywords_en><![CDATA[energy efficiency, fin and tube heat exchanger, latent heat storage, renewable energy sources, numerical simulations, experiment]]></keywords_en><summary_hr><![CDATA[Predmet istraživanja projekta je povećanje energetske učinkovitosti izmjenjivača topline. Istraživanja će biti usmjerena na analizu izmjene topline i povećanja energetske učinkovitosti lamelnih izmjenjivača topline te latentnog spremnika topline kao posebnog tipa izmjenjivača. Znanstveno-istraživački ciljevi projekta usmjereni su na produbljivanje znanstvenih spoznaja u području izmjenjivača topline te obuhvaćaju: numeričko i eksperimentalno istraživanje utjecaja geometrijskih karakteristika i pogonskih uvjeta izmjenjivača topline na fizikalni proces izmjene topline i učinkovitost, numeričko i eksperimentalno istraživanje utjecaja pogonskih uvjeta, geometrije i karakteristika akumulatora topline na izmjenu topline i učinkovitost latentnih spremnika te istraživanje pohrane energije u sustavu obnovljivih izvora energije s latentnim spremnikom.U okviru projekta nabavit će se i instalirati eksperimentalna oprema potrebna za provođenje eksperimentalnog dijela istraživanja. U svrhu provedbe numeričkih analiza, za svaki od problema istraživanja, definirat će se domena numeričkog proračuna, postaviti matematički model, odabrati numerička metoda i provesti numeričko rješavanje. Postavljeni matematički i računalni modeli bit će provjereni usporedbom rezultata s rezultatima eksperimentalnog istraživanja. Nakon provjere valjanosti, provest će se nizovi numeričkih simulacija u svrhu ispitivanja utjecaja različitih geometrijskih karakteristika i pogonskih uvjeta lamelnih izmjenjivača topline, kao i utjecaja pogonskih uvjeta, geometrije i karakteristika akumulatora topline latentnog spremnika na izmjenu topline i učinkovitost. Provest će se računalna analiza sustava obnovljivih izvora energije s latentnim spremnikom topline, za različite pogonske uvjete i dimenzije komponenata sustava. Očekivani rezultati i znanstveni doprinos obuhvaćaju proširenje postojećih znanstvenih spoznaja i prijedlog mjera za poboljšanje u svrhu povećanja energetske učinkovitosti izmjenjivača topline.]]></summary_hr><summary_en><![CDATA[The research topic of the project is the enhancement of the heat exchanger energy efficiency. Investigations will focus on the analysis of heat transfer and energy efficiency enhancement of the fin and tube heat exchanger and the latent heat storage as special type of heat exchanger.Scientific research objectives of the project are focused on enlarging of scientific knowledge in field of heat exchangers and include: numerical and experimental research of influence of heat exchanger geometry characteristics and operating conditions, as well as influence of latent heat storage operating conditions, geometry and phase change material characteristics on heat transfer and efficiency. Also, energy storing in system of renewable energy sources with latent heat storage will be studied.Experimental equipment, needed to carry out experimental part of the research, will be acquired and installed as part of the project. For purposes of numerical analysis, for each problem, domain for numerical calculation will be defined, mathematical model will be set up, numerical method will be chosen and numerical calculations will be performed. The established mathematical and computer models will be validated by comparing results with the results of experiments. After validation, series of numerical simulations will be carried out to investigate influence of different geometry characteristics and operating conditions of the fin and tube heat exchangers, as well as effects of operating conditions, geometry and characteristics of phase change material on heat transfer and efficiency of latent heat storage. Computational analysis of renewable energy system with latent heat storage, for different operating conditions and dimensions of system components, will be carried out.Expected results and scientific contributions include the enlarging of existing scientific knowledge and proposal of measures for improvement in order to enhance the heat exchanger energy efficiency.]]></summary_en></project><project>
<id>4314</id><title_hr><![CDATA[Genomske i epigenomske promjene u auto- i alopoliploidima na modelu dalmatinskog buhača, ljutike i anemona]]></title_hr><title_en><![CDATA[Genomic and epigenomic changes in auto- and allopolyploids: case studies on dalmatian pyrethrum, shalot and anemone]]></title_en><user_id>19769</user_id><user_firstLast_name>Višnja Besendorfer</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-8432</code><acronim><![CDATA[AutoAloPol]]></acronim><duration>01.04.2017 - 31.10.2022</duration><status>Završio</status><financ_value>129.802,91 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, Kemija, </scie_field_hr><scie_field_en>Biology, Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>3735, 4503, 19883, 19875, 19978, 19982, 25319, 29194, </team_members_id><team_members_names><![CDATA[Nenad Malenica, Ivana Ivančić Baće, Jelena Mlinarec, Jasna Puizina, Ivica Šamanić, Željana Fredototvić, Adela  Jurković, Mila Vuković, ]]></team_members_names><keywords_hr><![CDATA[autopoliploidija, alopoliploidija, genomika, epigenomika, evolucija biljnog genoma]]></keywords_hr><keywords_en><![CDATA[autopolyploidy, allopolyploidy, genomic, epigenomic, plant genome evolution]]></keywords_en><summary_hr><![CDATA[Poliploidija/udvostručavanje genoma glavni je pokretački mehanizam specijacije i bioraznolikosti biljaka koji dovodi do stvaranja novih genetičkih varijanti, pokreće evoluciju, povećava genetičku raznolikost organizama te ima veliku ulogu u domestikaciji biljaka. Iako su rađena brojna istraživanja još uvijek se malo zna o promjenama koje se događaju na razini genoma nakon poliploidizacije i hibridizacije. Auto- i alopoliploidija dovodi do nestabilnosti i reorganizacije genoma. Nepravilna segregacija kromosoma u mejozi glavni je problem za formiranje funkcionalnih gameta i uspješnog spolnog razmnožavanja novosintetiziranih autopoliploida. Evolucijski stari autopoliploidi razvili su mehanizme koji su s vremenom osigurali pravilnu segregaciju kromosoma. Točan mehanizam prelaska iz nestabilnog u stabilno stanje genoma nakon poliploidizacije još je nerazjašnjeno. Ovim projektom istražit će se mejotski procesi koji dovode do pravilne segregacije kromosoma i ekspresija gena uključenih u sparivanje kromosoma/homolognu rekombinaciju u autotetraploidu dalmatinskog buhača (T. cinerariifolium). Stabilizacija mejoze kroz mali broj generacija važna je za komercijalnu proizvodnju autotetraploida. Genomi alopoliploidnih vrsta izuzetno su dinamični zbog interakcija između subgenoma koje dovode do homogenizacije alopoliploida. Homogenizacija se odvija kroz genomske rearanžmane (inverzije, translokacije, trasnpozicije) i delecije dijelova genoma u koje su najčešće uključene ponavljajuće DNA kao i promjene u metilaciji DNA. Ovim projektom žele se na razini genoma i epigenoma utvrditi koji mehanizmi i u kojoj mjeri su uključeni u reorganizaciju genoma sterilne alotriploidne ljutike (A. × cornutum), fertilne alotetraploidne vrste A. multifida i aloheksaploidne A. baldensis. Istraživanja predložena ovim projektom pružit će bolji uvid u promjene na razini genoma i epigenoma u vrstama važnim za ljudsku prehranu, ekološku poljoprivredu i proizvodnju novih hortikulturnih varijanti.]]></summary_hr><summary_en><![CDATA[Polyploidy/genome duplication is the main mechanism of speciation and biodiversity in plants, drives evolution, increases genetic diversity and organism complexity, and plays an important role in domestication of plants. Although numerous studies have been conducted so far, we still don’t know enough about the genomic changes that are taking place after polyploidization and hybridization. Auto- and allopolyploidy lead to genome instability and reorganization. Improper chromosome segregation in meiosis is the main problem for functional gamete formation and successful sexual reproduction in neo-autopolyploids. Evolutionary old autopolyploids have developed mechanisms that lead to proper chromosome segregation but the exact mechanism of transition from unstable to stable genome condition after polyploidization is not fully understood. This project will study meiotic processes that lead to the proper chromosome segregation as well as gene expression involved in chromosome pairing/homologous recombination in autotetraploid pyrethrum (T. cinerariifolium). Stabilization of meiosis through a few generations is important for commercial production of autotetraploids. Genomes of allopolyploid species are extremely dynamic in terms of their subgenome interactions that lead to their homogenization. Homogenization is carried out through genomic rearrangements (inversions, translocations, transposition) and partial genome (rich in repetitive DNA) deletions as well as changes in DNA methylation. With this project we want to determine the mechanisms at the genome and the epigenome level which are involved in reorganization of subgenomes in sterile allotriploid shallot (A. x cornuntum) and fertile allotetraploid A. multifida and allohexaploid A. baldensis. The research proposed in this project will provide a better insight into changes at the genomic and epigenomic level in species important for human consumption, organic farming and the production of new horticultural varieties.]]></summary_en></project><project>
<id>4315</id><title_hr><![CDATA[Automatsko raspoznavanje akcija i aktivnosti u multimedijalnom sadržaju iz domene sporta]]></title_hr><title_en><![CDATA[Automatic recognition of actions and activities in multimedia content from sports domain]]></title_en><user_id>4775</user_id><user_firstLast_name>Marina Ivašić-Kos</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-8345</code><acronim><![CDATA[RAASS]]></acronim><duration>01.01.2017 - 31.05.2021</duration><status>Završio</status><financ_value>78.704,63 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Informacijske znanosti, Kineziologija, </scie_field_hr><scie_field_en>Information sciences, Kinesiology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Fakultet informatike i digitalnih tehnologija]]></institution_hr><institution_en><![CDATA[University or Rijeka, Faculty of Informatics and Digital Technologies]]></institution_en><team_members_id>19832, 20125, 20342, 25244, 25880, </team_members_id><team_members_names><![CDATA[Miran Pobar, Matija Burić, Jordi Gonzalez Sabaté, Kristian Stančin, Kristina Host, ]]></team_members_names><keywords_hr><![CDATA[raspoznavanje akcija, predstavljanje znanja, algoritmi zaključivanja, prostorno-vremenske značajke, vremenske neizrazite Petrijeve mreže]]></keywords_hr><keywords_en><![CDATA[action recognition, knowledge representation, inference algorithms, STIP features, timed Fuzzy Petri nets]]></keywords_en><summary_hr><![CDATA[Multimedijalni materijali poput digitalnih slika i videa postale su važan medij za pohranu i razmjenu informacija. U domeni sporta stvara se velik broj multimedijalnih materijala s različitih takmičenja, utakmica ili priprema te postoji jak interes za njihovom analizom kod sportaša i trenera, od amaterskih, preko profesionalnih do rekreativnih. U profesionalnom sportu takva analiza je danas neophodna ali još se uvijek vrši uglavnom ručnim označavanjem pojedinih akcija. Razvoj postupaka za automatsku detekciju akcija i tumačenje aktivnosti sportaša omogućio bi učinkovitiju analizu i širu dostupnost takvih rješenja svima koji se žele baviti sportom. Analiza pojedinih akcija kao što su npr. okret kod plivanja ili korak kod trčanja važna je za sportaše, trenere i fizioterapeute jer omogućuje praćenje točnosti izvođenja vježbi, unaprjeđenje njihove izvedbe te praćenje napretka. Za tumačenje više slijednih akcija i njihovo povezivanje u smislenu aktivnost potrebno je znanje iz domene sporta. Predlaže se istraživanje u kojem bi se razvili postupci za detekciju i označavanje akcija iz domene sporta u multimedijalnom sadržaju. Polazna točka za detekciju akcija bit će postupci temeljeni na strojnom učenju i značajkama koje opisuju prostorno-vremensku dimenziju multimedijalnog sadržaja. Za automatsko povezivanje i interpretaciju slijednih akcija u složenije aktivnosti razvit će se model temeljen na znanju o domeni sporta koja ima dobro definirana pravila, poznatu strukuru i kontekst te postoje jasne uloge sportaša i ostalih sudionika. Za modeliranje neizrazitog znanja o domeni i vremenskih odnosa definirat će se shema za predstavljanje znanja temeljena na teoriji vremenskih i neizrazitih Petrijevih mreža ili sličan formalizam. Zbog specifičnosti svakog sporta, u istraživanju će se razmatrati akcije iz odabranih sportova, no pri tome će se imati u vidu mogućnost primjene postupaka i na druge sportove. ]]></summary_hr><summary_en><![CDATA[Multimedia content such as digital images and video have become an important storage and exchange media. A large amount of such content from competitions, games and training sessions is constantly being created in the sports domain, and there has been a great interest for multimedia content analysis among athletes and coaches, on all levels from professional to recreational.Such analysis is indispensable in modern professional sports but is still done primarily by manual annotation of individual actions. Development of methods for automatic action detection and athlete’s activity interpretation would enable more efficient analysis and broaden the availability of analysis solutions to everyone involved with sports.Analysis of individual actions, such as swimming turns or steps in running, is important for athletes, coaches and physical therapists alike because it allows them to monitor the form of performing individual exercises, to improve the athlete’s performance and and to keep track of the progress. For interpretation of multiple sequential actions into a meaningful activity, sports domain knowledge is necessary.We propose a research in which methods for sports domain action detection and annotation in multimedia content would be developed. The starting point for action detection are methods based on machine learning and features that describe the spatio-temporal dimensions of multimedia content. For interpretation of sequential actions into more complex activities a model will be developed based on sports domain, which has well-defined rules, a known structure and context and clear roles exist for athletes and others involved. To model the fuzzy knowledge of the domain and temporal relations a knowledge representation scheme will be defined based on the theory of timed and fuzzy Petri nets or a similar formalism. Due to the specifics of different sports, actions from chosen sports will be considered in the research.]]></summary_en></project><project>
<id>4317</id><title_hr><![CDATA[Analiza složenosti mikrobne dinamike u invadiranim livadama morskih cvjetnica]]></title_hr><title_en><![CDATA[Unravelling the complexity of microbial dynamics in invaded seagrass meadows]]></title_en><user_id>462</user_id><user_firstLast_name>Mirjana Najdek Dragić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-7118</code><acronim><![CDATA[MICRO-SEAGRASS]]></acronim><duration>01.04.2017 - 31.08.2021</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, Kemija, </scie_field_hr><scie_field_en>Biology, Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>465, 12700, 473, 4664, </team_members_id><team_members_names><![CDATA[Ingrid Ivančić, Marino Korlević, Paolo Paliaga, Gerhard Herndl, ]]></team_members_names><keywords_hr><![CDATA[raznolikost mikroorganizama, morske cvjetnice, epifitski mikroorganizmi, bentički mikroorganizmi, NGS, izvori organske tvari, metabolički putevi]]></keywords_hr><keywords_en><![CDATA[microbial diversity, seagrasses, epiphytic microbes, benthic microbes, NGS, organic matter sources, metabolic pathways]]></keywords_en><summary_hr><![CDATA[Morske su cvjetnice među najvrijednijim biološkim sustavima na Zemlji. Nedavno uvedena u Jadransko more, invazivna makroalga vrste Caulerpa cylindracea (Sonder) predstavlja jednu od glavnih, ali nedovoljno istraženih prijetnji opstanku morskih cvjetnica. Učinak makroalge C. cylindracea na rast cvjetnica može imati sveobuhvatan kaskadni učinak na funkcioniranje ekosustava i podršku koju livade pružaju ekosustavu. Uloga mikroorganizama i njihovih složenih interakcija s morskim cvjetnicama u održavanju rasta i razvoja livada, posebno invadiranih livada nije dovoljno razjašnjena. Predloženi projekt će po prvi puta pružiti uvid u strukturu i raznolikost epifitskih i bentičkih mikrobnih zajednica livada morske cvjetnice vrste Cymodocea nodosa (Ucria) Ascherson i livada invadiranim makroalgom C. cylindracea. Visoka učestalost uzorkovanja omogućit će dubinsku analizu sezonske dinamike epifitskih i bentičkih mikrobnih zajednica. Usporedbom epifitskih i bentičkih mikrobnih zajednica livada cvjetnice C. nodosa i invadiranih livada, procijeniti će se utjecaj makroalge C. cylindracea na strukturu, raznolikost i dinamiku mikrobnih zajednica. Kombiniranjem metagenomskog sa metaproteomskim pristupom dobiti će se uvid u potencijalne i ostvarene mikrobne metaboličke puteve određivanjem funkcije mikroorganizama u ovom vrijednom ekosustavu. Profiliranje masnih kiselina razjasniti će doprinos različitih izvora ukupnoj organskoj tvari livada. Projekt će doprinjeti boljem razumijevanju uloge makroalge C. cylindracea u ekosustavu morskih cvjetnica, utjecaja na strukturu i pokrivenost epifitskim zajednicama, opskrbu bentičke mikrobne zajednice hranjivim tvarima u sedimentu livada, kao i utjecaj na kvalitetu i dostupnost organske tvari višim trofičkim razinama. Na kraju, projekt će značajno unaprijediti znanje o složenosti mikrobne dinamike u invadiranim livadama morskih cvjetnica isporukom dobro strukturiranog vremenskog niza podataka i primjenom molekularnih alata nove generacije.]]></summary_hr><summary_en><![CDATA[Seagrasses are among the most valuable biological systems on Earth. The recent introduction into the Adriatic Sea of the invasive macroalgae, Caulerpa cylindracea (Sonder) is one of the major but less-well understood threats for seagrasses. The impacts of C. cylindracea on seagrass performance can have a widespread cascade effects on ecosystem function and ecosystem services provision. The role of microorganisms and their complex interactions with seagrass, especially in invaded meadows, is poorly understood. The proposed project will deliver unprecedented insights into the structure and diversity of epiphytic and benthic microbial communities in the meadows of Cymodocea nodosa (Ucria) Ascherson and its C. cylindracea invaded meadows. High sampling frequencies will enable in-depth analysis of epiphytic and benthic microbial community seasonal dynamics. By comparison of epiphytic and benthic microbial communities of C. nodosa in non-invaded and invaded meadows, the impact of C. cylindracea on microbial structure, diversity and dynamics will be evaluated. A combination of metagenomic with metaproteomic approach will provide insight into potential and realized microbial metabolic pathways determining the function of microorganisms in this valuable ecosystem. Fatty acid profiling will clarify the contribution of different basal organic matter sources to seagrass meadows. This project will give a better understanding of the role of C. cylindracea in the seagrass ecosystem, its impact on the epiphytic community structure and cover, microbial nutrient cycling in seagrass sediments and influence of the quality and availability of organic matter to higher trophic levels. Finally, the project will substantially improve the knowledge of complex microbial dynamics in invaded seagrass meadows by delivering a well-structured temporal dataset and application of next-generation molecular tools.]]></summary_en></project><project>
<id>4321</id><title_hr><![CDATA[Dinamični hibridni materijali za novu primjenu temeljeni na metalnim nanočesticama i gelovima]]></title_hr><title_en><![CDATA[Dynamic Hybrid Metal Nanoparticles-Gel Materials for Novel Applications]]></title_en><user_id>4406</user_id><user_firstLast_name>Zoran Džolić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-5983</code><acronim><![CDATA[NanoGelMat]]></acronim><duration>15.03.2017 - 14.08.2021</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>5023, 5515, 2816, 25266, 25267, </team_members_id><team_members_names><![CDATA[Mario Cetina, Massimo Cametti, Marijana Vinković, Mateja Belovari, Toni Grgurić, ]]></team_members_names><keywords_hr><![CDATA[supramolekulska kemija, gelovi, metalne nanočestice, plazmoni, meki materijali]]></keywords_hr><keywords_en><![CDATA[supramolecular chemistry, gels, metal nanoparticles, plasmons, soft materials]]></keywords_en><summary_hr><![CDATA[Proučavanje fenomena kiralnosti kod anorganskih nanočestica postaje jedna od vodećih tema istraživanja u nanoznanosti. Otkrivena su nova i zanimljiva svojstva kiralnih nanočestica koja pokazuju buduću primjenu tih sustava u temeljnim (metamaterijali) i primijenjenim (medicinska dijagnostika, terapija karcinoma) istraživanjima. Kiralnost nanočestica je važan parametar u utrci minijaturizacije. Cilj je pripraviti kiralne nanočestice s efektom cirkularnog dikroizma induciranog površinskim plazmonom (SP-CD) u vidljivom i infracrvenom dijelu spektra. Napredak u ovom području istraživanja do sada je bio otežan zbog strukturne složenosti takvih sustava te kompliciranih metoda priprave kiralnih nanočestica. Zbog toga je razvoj učinkovitih metoda priprave kiralnih nanočestica jedan od vodećih izazova s kojim se nanoznanost danas suočava. Nedavno smo izložili novi pristup dizajnu i pripravi kiralnih nanočestica. U njemu je kiralna organizacija nanočestica dobivena upotrebom predloška, supramolekularne gelne niti, po kojem je raspored nanočestica dirigiran &#39;&#39;upisanom informacijom&#39;&#39; unutar gelnih niti. Našim pristupom plazmonski cirkularni dikroizam je dobiven samo-udruživanjem zlatnih nanoštapića po predlošku, gelne niti, s upletenom (engl. twisted) morfologijom. Spektri cirkularnog dikroizma su pokazali intenzivne plazmonom-inducirane Cottonove efekte, a dobivene su do sada najviše vrijednosti anizotropnog faktora za metalne nanočestice u otopini. Predloženi projekt ima za za cilj pojasniti porijeklo fenomena kiralnosti kod anorganskih nanočestica i na molekularnoj razini proširiti saznanja o interakcijama između anorganskih nanočestica i molekula gelatora unutar gelne mreže. Nadalje, unutar ovog projekta planirano je istražiti, upotrebom oksalamidnih derivata kao molekula gelatora, mehanizam nastajanja gelnih niti s kiralnom morfologijom, kao i mogućnosti kontrole dobivene morfologije. ]]></summary_hr><summary_en><![CDATA[The observation of chirality on inorganic nanoparticles (NPs) systems is an interesting and highly important phenomenon which has recently attracted considerable attention and has become a hot topic in nanoscience research. Many novel and interesting properties of chiral NPs have been explored and studied, showing that these systems could be of significant importance in both fundamental and application-oriented research. Very recently we have introduced a new strategy for designing and preparing chiral NPs which relies on a gelator fiber-templated approach in which the local organization is driven by the information already inscribed on the gel fibers. Plasmonic circular dichroism was obtained by chiral 3D organisation of gold nanorods, generated by their self-assembly onto a gel fiber template with twisted morphology. Circular dichroism measurements revealed intense plasmon-induced Cotton effect, and the highest anisotropy factor for metal nanoparticles in solution reported so far. The aim of this project is to gain a molecular-level understanding of the interaction of NPs with the gelators within the gel matrix and of the origin of the chirality observed in the inorganic NPs. Furthermore, a comprehensive understanding of the mechanism of the twist formation and control the chiral twists in oxalamide-based gelator assemblies will be sought. The long-term objective of this project is to explore the correlation between the morphology of the chiral gel fibers and the SP-CD responses of NPs. More specifically, the project will focus on (1) the preparation of nanocomposite chiral materials built-up from supramolecular fibers of different morphology serving as templates for surface assembly of NPs; (2) the screening of their optical properties and on identifying the factors responsible for an efficient optical enhancement; (3) the determination of the characteristics and the origins of the chirality in NPs.]]></summary_en></project><project>
<id>4329</id><title_hr><![CDATA[Sto dvadeset i pet  milijuna piksela za otkriće vezanja Higgsovog bozona na fermione i novih čestica na Velikom hadronskom sudarivaču]]></title_hr><title_en><![CDATA[Hundred twenty five Megapixels to discover Fermionic Higgs couplings and New Particles at the Large Hadron Collider]]></title_en><user_id>11164</user_id><user_firstLast_name>Vuko Brigljević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-3321</code><acronim><![CDATA[HIGGS125]]></acronim><duration>12.06.2017 - 31.08.2022</duration><status>Završio</status><financ_value>129.975,45 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>19705, 19738, 28912, 864909, 1086, 864951, 29408, 864907, </team_members_id><team_members_names><![CDATA[Tatjana  Šuša, Dinko Ferenček, Andrey Starodumov, Devdatta Majumder, Krešimir Jakovčić, Matej Roguljić, Saswat Mishra, Bhakti Kanulal Chitroda, ]]></team_members_names><keywords_hr><![CDATA[Higgsov bozon, fermionska vezanja, Standardni model, nove čestice, identifikacija b kvarkova, piksel detektor, LHC]]></keywords_hr><keywords_en><![CDATA[Higgs boson, fermionic couplings, Standard model, new particles,  b tagging, pixel detector, LHC]]></keywords_en><summary_hr><![CDATA[Ulaskom u drugu fazu rada Velikog hadronskog sudarivača čestica (LHC) na CERN-u započelo je još jedno uzbudljivo razdoblje u istraživanju temeljnih gradivnih  elemenata tvari. Opažanjem čestice sa svojstvima Higgsovog bozona na LHC-u čini se da je potvrđeno jedno od središnjih predviđanja Standardnog modela (SM) fizike čestica.  Međutim, sva svojstva otkrivene čestice tek se trebaju precizno odrediti kako bi se potvrdilo da je ona uistinu Higgsov bozon predviđen Standardnim modelom.  Cilj projekta je proučavanje vezanja Higgsovog bozona s fermionima, koja su u SM-u odgovorna za mase kvarkova i leptona. Ova vezanja dopuštaju raspade  Higgsovog bozona u fermione.  Međutim, takvi raspadi još nisu opaženi. Cilj projekta je opažanje raspada Higgsovog bozona u par b kvarkova  te precizno mjerenje učestalosti ovog raspada koristeći sve podatke koji će se prikupiti detektorom CMS u drugoj fazi rada LHC-a. Neopažanje ovog raspada ili odstupanje učestalosti raspada od vrijednosti predviđenih SM-om ukazalo bi na postojanje fizike izvan SM-a što bi bilo od iznimne važnosti. Cilj projekta su i izravne potrage za novim česticama proučavanjem konačnih stanja s b kvarkovima.  Projekt također namjerava pridonijeti poboljšanju performansi detektora CMS boljom identifikacijom hadronskih mlazova koji nastaju hadronizacijom b kvarkova (b mlazovi). Unapređenju identifikacije b mlazova (B označavanje) ponajviše će doprinijeti instalacija nadograđenog silicijskog piksel detektora početkom 2017. Jedan od ciljeva projekta je optimizacija performansi identifikacije b mlazova koristeći svojstva nadograđenog detektora, s posebnim naglaskom na označavanje topologija u kojima su se dva vrlo energijska b mlaza spojila u jedan mlaz. To će ovisiti o dobroj integraciji nadograđenog piksel detektora u CMS mjerenja, te projekt također uključuje niz ciljeva vezanih uz poboljšanje performansi piksel detektora i rekonstrukcije događaja.]]></summary_hr><summary_en><![CDATA[With the start of the second running phase (Run 2) of the Large Hadron Collider (LHC) at CERN, the study of the fundamental constituents of matter has again entered an exciting time. The observation of a Higgs-like boson at the LHC seems to confirm a central prediction of the Standard Model (SM) of particle physics. All properties of the discovered particle need however to be accurately determined to establish whether the new particle is the Higgs boson predicted in the SM.The proposal aims at studying the couplings of the Higgs boson to fermions, which in the SM gives rise to masses of quarks and leptons. These couplings allow the Higgs boson to decay into fermions. No such decay has however been observed yet. This projects targets an observation of the Higgs boson decay into a pair of b quarks, and a precise measurement of this decay rate using the full dataset to be acquired by the CMS detector during Run 2. A lack of observation of this decay or a deviation of its rate from the SM expectation would point at the presence of physics beyond the SM and be of great significance. The project also aims at direct searches for new particles by studying final states with b quarks.The project also intends to contribute to the improved performance of the CMS detector by improving the identification of hadronic jets stemming from the hadronization of a b quark (b-jets). The identification of b-jets (B tagging) will in particular benefit from the installation of an upgraded silicon pixel detector in early 2017. One of the project goals consists in optimizing the B tagging performance using the features of the upgraded detector, with a special focus on the tagging of topologies in which two very energetic b-jets are merged in one so-called “fat jet”. This relies on a good integration of the upgraded pixel detector in the CMS measurements, and the project therefore also includes a set of objectives linked to the improvement of the pixel detector performance and reconstruction.]]></summary_en></project><project>
<id>4332</id><title_hr><![CDATA[Opterećenja vjetra i mora na energetske konstrukcije]]></title_hr><title_en><![CDATA[Wind and sea loads on energy structures]]></title_en><user_id>4960</user_id><user_firstLast_name>Hrvoje Kozmar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-2017</code><acronim><![CDATA[WESLO]]></acronim><duration>01.04.2017 - 30.09.2021</duration><status>Završio</status><financ_value>132.324,64 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, </scie_field_hr><scie_field_en>Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>5118, 6437, 5584, 252, 13308, 17884, 19684, 19466, 19443, 25331, 29416, 862796, </team_members_id><team_members_names><![CDATA[Ivo Džijan, marko tomić, Ivan Ćatipović, Nikola Vladimir, Neven Hadžić, Andrija Buljac, Željko Večenaj, Mihael Cindori, Franjo Juretić, Danijel Bosnar, Petar Škvorc, Petar Golem, ]]></team_members_names><keywords_hr><![CDATA[Inženjerstvo vjetra, aerodinamika okoliša, vjetar i konstrukcije, opterećenja mora, vjetroturbina, pučinska konstrukcija, zračni tunel]]></keywords_hr><keywords_en><![CDATA[Wind engineering, environmental aerodynamics, wind and structures, sea loads, wind turbine, offshore structure, wind tunnel]]></keywords_en><summary_hr><![CDATA[Vjetroturbine i pučinske platforme su izložene ekstremnim vremenskim uvjetima uključujući djelovanje vjetra, mora i valova. Da bi se produljio njihov vijek trajanja i povećala učinkovitost nužno je pažljivo analizirati utjecaje opterećenja okoliša na te objekte i predložiti odgovarajuća inženjerska rješenja. Uočeno je da su opterećenja vjetra, valova i mora na pučinske energetske objekte prethodno uglavnom bila analizirana odvojeno. Također se aerodinamička opterećenja na vjetroturbine u blizini brdovite obale i otoka bitno razlikuju od opterećenja na ravnom terenu i otvorenoj pučini, a karakteristike mahovitih vjetrova su u velikoj mjeri nepoznate u inženjerskim krugovima. Uz modelska laboratorijska ispitivanja, važan alat predstavljaju i računalne simulacije, u kojima trenutno nije moguće adekvatno reproducirati karakteristike atmosferske turbulencije. Sukladno navedenom vrlo aktualne istraživačke teme su: a) karakterizacija ekstremnih opterećenja i odziva vjetroturbina i platformi istovremeno uzrokovanih vjetrom, valovima i morskim strujama, b) aerodinamička opterećenja vjetroturbina u blizini brdovitog terena, c) karakteristike turbulencije mahovitog vjetra bure u obliku prikladnom za inženjersko projektiranje konstrukcija, d) metodologija računalne simulacije atmosferskog graničnog sloja i primjena na proračun opterećenja vjetroturbina i platformi. Da bi se navedeni ciljevi u potpunosti ostvarili u radu će biti korištene napredne istraživačke metode uključujući mjerenja u prirodi, laboratorijske eksperimente, računalnu mehaniku i dinamiku fluida. Budući da se integralna opterećenja vjetra, valova i morskih struja na energetske konstrukcije u potpunosti mogu analizirati isključivo kroz suradnju različitih grana znanosti i tehnike, istraživačka grupa u okviru ovog projekta na jedinstveni način uključuje stručnjake iz područja strojarstva, građevine, meteorologije i pomorske tehnike.]]></summary_hr><summary_en><![CDATA[Wind turbines and offshore platforms are exposed to a harsh marine environment including wind, wave and sea current loads. To extend their lifetime and increase energy production, it is necessary to carefully analyze effects of environmental loads on those structures and suggest appropriate engineering solutions. In the past, wind, wave and sea loads on offshore energy structures were commonly studied separately. In addition, aerodynamic loads on wind turbines close to hilly coast and islands are considerably different than the loads on wind turbines in flat terrain and open sea, whereas transient wind characteristics are fairly unknown to engineers. In addition to laboratory experiments, computational simulations are valuable tools to determine wind and sea loads on wind turbines and platforms. An important drawback with this approach at the moment is that it is not possible to completely accurately simulate characteristics of atmospheric turbulence. Hence, very contemporary research topics are: a) characterization of extreme loads and response of wind turbines and platforms simultaneously induced by wind, waves and sea currents, b) aerodynamic loads on wind turbines in complex terrain, c) characteristics of bora wind turbulence in a form usable for engineering design of structures, d) computational simulation methodology for the atmospheric boundary layer and application on wind-turbine and platform loads. To achieve those goals, various advanced research tools will be used including field measurements, small-scale laboratory experiments, computational mechanics and fluid dynamics. As integral wind, wave and sea current loads on energy structures can be completely analyzed only in case different engineering/science disciplines are involved, the research group on this project uniquely includes experts from mechanical and civil engineering, meteorology and offshore engineering in a unique blend of disciplines.]]></summary_en></project><project>
<id>4339</id><title_hr><![CDATA[Optička svojstva heterostruktura dihalkogenida prijelaznih metala ]]></title_hr><title_en><![CDATA[Optical Properties of Transition Metal Dichalcogenide Heterostructures]]></title_en><user_id>13782</user_id><user_firstLast_name>Marko Kralj</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-3211</code><acronim><![CDATA[OhTMD]]></acronim><duration>01.03.2017 - 30.09.2021</duration><status>Završio</status><financ_value>127.712,52 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut za fiziku]]></institution_hr><institution_en><![CDATA[Institute of Physics in Zagreb]]></institution_en><team_members_id>6225, 3090, 19987, 19881, 856049, </team_members_id><team_members_names><![CDATA[Nataša  Vujičić, Iva Šrut Rakić, Davor Čapeta, Borna Pielić, SHEIKH MUHAMMAD OBAIDULLA, ]]></team_members_names><keywords_hr><![CDATA[2D materijali, heterostrukture, optoelektronika, međudjelovanje slojeva, CVD sinteza, optički odziv]]></keywords_hr><keywords_en><![CDATA[2D materials, heterostructures, optoelectronics, interlayer coupling, CVD synthesis, optical response]]></keywords_en><summary_hr><![CDATA[Glavni cilj ovog projekta je razviti razumijevanje efekata međudjelovanja između slojeva u heterostrukturama dvodimenzionalnih (2D) dihalkogenida prijelaznih metala (TMD) i upotrijebiti te spoznaje za formiranje struktura i uređaja sa željenim optičkim svojstvima. Intrinzična poluvodička priroda TMD slojeva, direktni procjep u limitu debljine jednog sloja, te potisnuto zasjenjenje u atomski tankom materijalu, čine ove materijale idealnim građevnim jedinicama  za razvoj raznolikih optoelektroničkih primjena, primjerice foto-detektora i foto-dioda, LED dioda i fotonaponskih ćelija. Strategija u provođenju sistematske analize interakcija slojeva bazira se na jedinstvenom uređaja za depoziciju iz kemijskih para (CVD) sa in situ mikroskopskim optičkim pristupom. CVD rast vertikalnih heterostruktura provodit će se u više koraka. Istovremeno sa direktnom sintezom, pripremat ćemo heterostrukure pomoću mehaničkog transfera slojeva, kako bi usporedili njihovu kvalitetu sa CVD uzorcima. Velika pažnja posvetit će se nano-strukturnoj karakterizaciji uzoraka pomoću mikroskopija skenirajućom probom, kako bi se identificirali defektikoji utječu na transport naboja i lokalna optička svojstva. Testirat će se optička svojstva s obzirom na interkalaciju materijala između slojeva što je vezano s promjenama u optičkom odgovoru i mogućim strukturnim promjenama zbog polimorfne prirode TMD. Odabrane heterostrukture biti će kontaktirane u uređaje kako bi se uvela dodatna mogućnost mijenjanja optičkih svojstva.Glavni eksperimentalni napor u ovom projektu usmjerit će se na razvoj postava za mjerenje optičkog odziva putem refleksije, fotoluminiscencije i Ramanove spektroskopije. Mjereni optički odaziv biti će direktno koreliran sa jačinom međudjelovanja između slojeva u heterostrukturama. Optički odziv mjerit će se i u pump-probe eksperimentima.]]></summary_hr><summary_en><![CDATA[The main goal of this project is to understand the effects of interlayer coupling in heterostructures of two-dimensional (2D) semiconducting transition metal dichalcogenides (TMDs) and use this knowledge to form structures and devices with desired optical response. The intrinsic semiconducting character of many TMDs, direct band gap in monolayer limit and suppressed screening effect in atomically thin form, makes these materials ideal building blocks for developing optoelectronic applications, including photodetectors, photodiodes, light-emitting devices, and photovoltaic cells. The strategy for performing systematic study of interlayer coupling is based on our unique capability to observe the chemical vapor deposition (CVD) growth process in situ by optical microscopy. The setup will be exploited in the multistep CVD growth of vertical heterostructures. Parallel to direct synthesis we will also form heterostructures by mechanical transfer in order to compare its quality to CVD growth. Great care will be also dedicated to nano-scale structural characterization of heterostructures, where scanning probe microscopy will be used to identify defects which affect charge transport and local optical response of the structures. We will test optical response regarding intercalation into the heterostructure interface, which is related to local modification of the optical response and possible structural changes caused by polymorphic nature of TMDs. We will contact selected individual heterostructures allowing us further degree of freedom in the control of the optical response. The major experimental effort in this project will be a development of capabilities to measure specific optical response via reflectivity, photoluminescence and Raman spectroscopy measurements. The optical response measurements will be directly correlated to the interlayer coupling in heterostructures. The optical response will be also investigated by pump-probe measurements.]]></summary_en></project><project>
<id>4343</id><title_hr><![CDATA[Klimatske promjene i invazivne vrste – utvrđivanje utjecaja na bioraznoliost nativnih slatkovodnih rakova i pastrva i njihova konzervacija]]></title_hr><title_en><![CDATA[Climate change and invasive species – assessing effects onto biodiversity of native freshwater crayfish and salmonids and their conservation ]]></title_en><user_id>12634</user_id><user_firstLast_name>Ivana Maguire</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-2563</code><acronim><![CDATA[CLINEinBIOta]]></acronim><duration>01.03.2017 - 30.09.2021</duration><status>Završio</status><financ_value>103.033,03 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>1292, 11179, 7664, 19951, 4269, 19943, 12871, 25076, 25082, 25092, 25329, </team_members_id><team_members_names><![CDATA[Marina Piria, Martina Temunović, Goran Klobučar, Ana Tošić, Martina Podnar Lešić, Predrag Simonović, Sanja Gottstein, Andrea Rezić, Ivan Špelić, Tamara Kanjuh, Leona Lovrenčić, ]]></team_members_names><keywords_hr><![CDATA[genetska varijabilnost, evolucijska povijest, Astacus astacus, Austropotamobius torrentium, Salmo trutta, modeli pogodnosti staništa]]></keywords_hr><keywords_en><![CDATA[genetic variability, evolutionary history, Astacus astacus, Austropotamobius torrentium, Salmo trutta, habitat suitability models]]></keywords_en><summary_hr><![CDATA[Slatkovodni su ekosustavi pod sve većim antropogenim pritiskom što negativno utječe na njihovu bioraznolikost, a time i na njihovo funkcioniranje te usluge koje pružaju. Bioraznolikost posebice ugrožavaju globalne klimatske promjene i unos stranih vrsta. Stoga je cilj ovog projekta istražiti njihov utjecaj na slatkovodne organizme. U fokusu predloženog projekta su tri slatkovodne zavičajne vrste (potočni i plemeniti rak, potočna pastrva) koje imaju ključnu ulogu u ekosustavima, osiguravaju njihovo normalno funkcioniranje (rakovi) i ekonomski su značajne (pastrve). Njihov nestanak iz staništa značajno mijenja slatkovodne ekosustave, dovodi do promjena u dinamici transporta sedimenta te uzrokuje promjene u sastavu zajednica. Ove su vrste osjetljivi na promjene u staništu, a zbog negativnog antropogenog utjecaja i sve izraženijih klimatskih promjena, ugrožene su i zaštićene međunarodnim i nacionalnim zakonima.Cilj predloženog projekta je istražiti genetsku varijabilnost odabranih populacija ove tri vrste upotrebom mitohondrijskih, nuklearnih i mikrosatelitnih DNA biljega i doprinijeti novim spoznajama o njihovoj evolucijskoj povijesti i nasljeđu te identificirati njihove evolucijski bitne jedinice i jedinice upravljanja. Isto tako cilj je razviti modele potencijalno pogodnih područja za invazivne vrste rakova i strane linije pastrva kako bismo mogli predvidjeti područja i zavičajne populacije koja će biti pod njihovim najvećim pritiskom u budućnosti. Nadalje, cilj je izraditi modele pogodnosti staništa za proučavane zavičajne vrste, te njihova projekcija u budućnost prema različitim scenarijima klimatskih promjena što će omogućit identifikaciju područja koja će biti izrazito nepogodna za njihovo preživljavanje, kao i područja koja će osigurati njihov dugotrajni opstanak. Očekujemo da će dobiveni rezultati poslužiti kao kvalitetna osnova za izradu adekvatnih konzervacijskih strategija i planova upravljanja s ove tri osjetljive i ključne vrste slatkovodnih ekosustava. ]]></summary_hr><summary_en><![CDATA[Freshwater ecosystems are under growing anthropogenic pressure that negatively influence onto their biodiversity, and consequently onto alteration of ecosystem processes and impairment of ecosystem services. Nowadays, climate change and introduction of non-native species are recognised as one of the main factors of freshwater biodiversity loss. Therefore, objective of this project is to study their influence onto freshwater organisms. In the focus of the proposed project are three freshwater native species (stone and noble crayfish, brown trout) that have key role in the ecosystems; crayfish ensuring their normal functioning and trout being economically important.  Their disappearance from a habitat significantly alters freshwater ecosystem processes, species abundance and diversity. These three species are highly sensitive to habitat alteration, and due to negative human impacts onto their habitats and pronounced climate changes, they are vulnerable and protected by international and national legislation. The purpose of proposed project is to study genetic variability of different populations of these three species using mitochondrial, nuclear and microsatellite DNA markers, aiming to bring new insight into their evolutionary history and to identify their evolutionary significant and management units. Further, the aim is to develop habitat suitability models for non-native invasive crayfish species and allochthones trout lineages that would enable us to foresee areas that will be under biggest pressure in the future. Also, the aim is to develop habitat suitability models for native species future distribution under climate change scenarios that will enable us to identify areas, which will be unsuitable for their survival as well as areas that will ensure their long-term survival. We expect that obtained results will serve as a sound base for development of conservation strategies and management plans for these three vulnerable freshwater species.]]></summary_en></project><project>
<id>4344</id><title_hr><![CDATA[Relevantnost hermeneutičkog prosuđivanja]]></title_hr><title_en><![CDATA[Relevance  of Hermeneutical Judgment ]]></title_en><user_id>4842</user_id><user_firstLast_name>Jure Zovko</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-5672</code><acronim><![CDATA[RHJ]]></acronim><duration>01.03.2017 - 31.10.2021</duration><status>Završio</status><financ_value>34.507,93 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filozofija, Filologija, </scie_field_hr><scie_field_en>Philosophy, Philology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zadru]]></institution_hr><institution_en><![CDATA[University of Zadar]]></institution_en><team_members_id>5236, 5387, 5379, 5660, 5375, </team_members_id><team_members_names><![CDATA[Marie-Elise Zovko, Ante Periša, Ljubiša Prica, Marko  Vučetić, Nives Delija Trešćec, ]]></team_members_names><keywords_hr><![CDATA[Hermeneutika, prosudba, interpretacija, razumijevanje, um, humanistika]]></keywords_hr><keywords_en><![CDATA[Hermeneutics, Judgment, Interpretation, Understanding, Reason, Humanities]]></keywords_en><summary_hr><![CDATA[Primarna intencija ovog planiranoga istraživanja jest pokazati da je hermeneutička prosudba integralni dio teorije razumijevanja i interpretacije. Tradicionalno, strogo metodološko razlikovanje između prirodnih i humanističkih znanosti posve je neodrživo (W. Dilthey, M. Heidegger, Charles Percy Snow, Hans-Georg Gadamer). Razumijevanje nije samo obilježje humanističkih znanosti, nego je također krucijalni segment prirodnih i tehničkih znanosti. Svrha prijavljenoga istraživačkoga projektnoga prijedloga jest razmotriti hermeneutičku metodologiju u kontekstu suvremenih promjena paradigma i pragmatičnoga zaokreta s posebnim osvrtom na filozofiju. Primarno ćemo se usredotočiti na relevantnost prosuđivanja u procesu razumijevanja i na hermeneutičku interpretaciju te pokazati da postupak razumijevanja ne podrazumijeva samo rekonstrukciju stvaralaštva duha, nego također njegovu prosudbu, vrjednovanje i sustavnu analizu.Uspješno kultiviranje sposobnosti prosuđivanja podrazumijeva stručnu kompetentnost i sposobnost refleksivne analize svega onoga što predstavlja stvaralaštvo ljudskoga duha, kulturnu baštinu. Na primjeru analize filozofskih djela kao što su Kantova Kritika moći suđenja, Wittgensteinovi kasni spisi,  te suvremene recepcije Hegelove praktične filozofije (Pippin, Brandom, McDowell, Honneth) razmotrit ćemo u kojoj je mjeri  kultiviranje duha preduvjet za uspješnu interpretaciju i prosudbu stvaralačkoga djela, kao i za kritičko suočavanje s postojećim formama kulturnoga i društvenoga životnoga svijeta te svega onoga što predstavlja interpretandum. U tom kontekstu kultiviranja ljudskoga uma i prosudbe razmotrit ćemo zahtjevnu ulogu i zadaću obrazovanja. ]]></summary_hr><summary_en><![CDATA[The proposal’s primary intention is to show that hermeneutical judgment is an integral part of the theory of understanding and interpretation. The traditional strict methodological distinction between the natural sciences and the humanities (Dilthey, Heidegger, Snow, Gadamer) is no longer acceptable.  Understanding is not only a feature of the humanities, but also a crucial segment of the natural sciences and engineering.Our aim is to examine hermeneutical methodology in the context of changing paradigms and the pragmatic turn, in particular with regard to philosophy. Primarily, we will focus on the relevance of judgment in the process of understanding, interpretation and explanation. In this context, we will show that the process of understanding presupposes not only a reconstruction of the products of human intelligence and creativity, but also their judgment, evaluation, and systematic analysis. The successful cultivation of judgement requires informed competence and the capacity for reflective analysis of higher-level manifestations of the human spirit which form the content of our cultural heritage and whose interpretation forms the specific task of the humanities. On the basis of analysis of works such as Kant&#39;s Critique of Judgment, Wittgenstein’s late works, and contemporary interpretation of Hegel’s practical philosophy (Pippin, Brandom, McDowell, Honneth) the project will investigate to what extent cultivation of mind is a precondition for successful interpretation and judgment of, as well as for critical confrontation with, forms of cultural and social production. We will consider to what extent understanding in the humanities presupposes the reflective capacity of judgment and in what manner study of content and topics from the humanities contributes to cultivation and sharpening of the ability to judge, evaluate and comprehend the intepretandum. In the context of the analysis of judgment we will consider the role and task of education.]]></summary_en></project><project>
<id>4346</id><title_hr><![CDATA[Koherencija pisanoga teksta u inome jeziku: hrvatski, njemački, engleski, francuski i mađarski jezik u usporedbi]]></title_hr><title_en><![CDATA[Textual Coherence in Foreign Language Writing: Croatian, German, English, French and Hungarian in Comparison]]></title_en><user_id>19861</user_id><user_firstLast_name>Vesna  Bagarić Medve </user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-5736</code><acronim><![CDATA[KohPiTekst]]></acronim><duration>01.03.2017 - 30.06.2020</duration><status>Završio</status><financ_value>38.977,11 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filologija, </scie_field_hr><scie_field_en>Philology, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>19851, 19842, 19853, 20085, 19014, 19841, 20102, 19838, 19925, 20015, 7052, 4220, 25365, 25368, 25353, 25369, </team_members_id><team_members_names><![CDATA[Višnja Pavičić Takač, Leonard Pon, Draženka Molnar, Sanja Cimer, Ninočka Truck Biljan, Ana Mikić Čolić, Ivana Trtanj, Vedrana Berlengi, Beatrix Oszko, Milica Sabo, Lidija Cvikić, Antonia Ordulj, Vlatka Ivić, Manuela Karlak, Ivana Šarić Šokčević, Zoltan Medve, ]]></team_members_names><keywords_hr><![CDATA[koherencija teksta, metoda analize koherencije teksta, kohezija, strategije, prvi jezik, ini jezik ]]></keywords_hr><keywords_en><![CDATA[textual coherence, method for analysis of textual coherence, cohesion, strategies, first language, foreign language]]></keywords_en><summary_hr><![CDATA[Koherencija je prema brojnim primijenjenim lingvistima ključna komponenta diskursne kompetencije, uz koju se, međutim, veže niz otvorenih problema za čije je rješavanje potrebno sustavno empirijsko istraživanje. Istraživanje u okviru projektnoga prijedloga bavi se opisom i usporedbom obilježja i načina postizanja koherencije u tekstovima korisnika hrvatskoga, njemačkoga, engleskoga,  francuskoga i mađarskoga kao inoga jezika u usporedbi s obilježjima i načinom postizanja koherencije u tekstovima na njihovom materinskom jeziku. U skladu s tim, u istraživanju će se analizirati obilježja koherentnosti teksta korisnika inoga jezika, kao i čimbenici koji utječu na (ne)koherentnost teksta u inome jeziku. Također, analizirat će se povezanost uporabe kohezivnih sredstava i razine koherentnosti teksta u inome jeziku. Nadalje, ispitat će se postojanje razlika u obilježjima i načinima postizanja koherentnosti teksta s obzirom na osobna obilježja korisnika inoga jezika (spol, obrazovni profil, razina jezičnoga znanja, formalni i neformalni kontekst ovladavanja inim jezikom) i vanjske čimbenike (način na koji nastavnik konceptualizira koherenciju). Konačno, ispitat će se strategije koje korisnici inoga jezika upotrebljavaju u svrhu postizanja koherentnosti teksta.Ispitanike u istraživanju činit će 290 studenata iz četiriju država (iz Hrvatske, Mađarske, Njemačke i Velike Britanije) te 40 edukatora koji su učitelji spomenutih jezika ili djeluju kao procjenjivači ispita pisanja na navedenim jezicima. U svrhu prikupljanja podataka koristit će se metoda testiranja, metoda anketiranja, metoda intervjuiranja te metoda glasnog navođenja misli. Prikupljeni podatci analizirat će se primjenom metode analize koherencije teksta, korpusnolingvističke metode i statističke metode.Predloženo je istraživanje interdisciplinarnoga karaktera. Uz tekstnu i primijenjenu lingvistiku polazi od teorijskih i empirijskih spoznaja psiholingvistike, pragmatike, diskursne i korpusne analize. ]]></summary_hr><summary_en><![CDATA[According to many applied linguists, coherence is a key component of discourse competence. The concept of coherence is, however, related to the whole range of open problems. A systematic empirical investigation is needed to address those problems.   The research within this project proposal deals with the description and comparison of coherence features and the ways of developing coherence in texts written by foreign language learners of German, English, Hungarian, French, and Croatian compared to coherence properties and the ways of developing textual coherence in their respective mother tongues. The proposed research project will analyse coherence features of texts written by foreign language learners as well as factors responsible for (in)coherence in foreign language texts. It will also examine the interrelation between the use of cohesive devices and the level of textual coherence in a foreign language. Furthermore, it will investigate the possible differences in coherence properties and the ways of achieving coherence with regard to several personal traits of foreign language users as well as some external factors. Finally, the strategies employed by foreign language users for developing textual coherence will be examined.The participants in the research will be 290 students from Croatia, Hungary, Germany, and Great Britain as well as 40 educators working as teachers and/or raters of tests written by learners of the abovementioned languages. In the research, the data will be gathered using the following instruments and methods: language tests, surveys, interviews and a think-aloud protocol. The data will be analysed using the method of analysing textual coherence, methods of corpus linguistics and statistical methods. The proposed project is highly interdisciplinary; it is grounded in the theoretical and empirical findings in the area of applied linguistics, text linguistics, psycholinguistics, pragmatics, discourse and corpus linguistics. ]]></summary_en></project><project>
<id>4351</id><title_hr><![CDATA[Željeznodobni ženski identiteti u južnom dijelu Karpatske kotline]]></title_hr><title_en><![CDATA[Iron Age Female Identities in the Southern Carpathian Basin]]></title_en><user_id>7071</user_id><user_firstLast_name>Marko Dizdar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-1749</code><acronim><![CDATA[FEMINE]]></acronim><duration>01.04.2017 - 30.09.2021</duration><status>Završio</status><financ_value>78.903,71 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Arheologija, </scie_field_hr><scie_field_en>Archeology, </scie_field_en><institution_hr><![CDATA[Institut za arheologiju]]></institution_hr><institution_en><![CDATA[Institute of Archaeology in Zagreb]]></institution_en><team_members_id>19335, 19103, 19809, 3432, 19659, 19792, 7022, 19091, 3646, 25275, 21180, </team_members_id><team_members_names><![CDATA[Saša Kovačević, Marija Ljuština, Aleksandar Kapuran, Hrvoje Potrebica, Asja Tonc, Mathias Mehofer, Metzner-Nebelsick Carola, Aurel Rustoiu, Daria Ložnjak Dizdar, Julia Katarina Kramberger, Antonela Barbir, ]]></team_members_names><keywords_hr><![CDATA[željezno doba, žene, identitet, Karpatska kotlina, nošnja, nakit, grobovi, groblja, rod, funkcionalna analiza, bioarheologija]]></keywords_hr><keywords_en><![CDATA[Iron Age, females, identity, Carpathian Basin, costume, jewellery, graves, cemeteries, gender, functional analysis, bioarchaeology]]></keywords_en><summary_hr><![CDATA[Cilj predloženoga projekta o razdoblju željeznoga doba, poduzetoga od strane arheologije u suradnji s antropološkim i arheometalurškim istraživanjima, naglasak stavlja na proučavanje različitih aspekata željeznodobnih (ŽD) ženskih društvenih identiteta koji se jedino mogu rekonstruirati iz arheoloških podataka. U projektu je predviđeno istraživanje zajedničkih modela, uz korištenje trenutnih interdisciplinarnih mogućnosti, koji se odnose na proučavanje rodnoga koncepta, što će predstavljati inovativnu aktivnost i značajan napredak u istraživanju ŽD zajednica u južnom dijelu Karpatske kotline (KK). Ženski identitet sastavljen je od višestrukih značajki koje su združene kako bi stvorile individualnu osobnost. Za vrijeme života pojedinac ima različite društvene identitete, čak i po nekoliko u isto vrijeme. Žene za vrijeme ŽD u južnom dijelu KK postaju posebno vidljive na osnovi arheoloških nalaza koji pokazuju razvoj brojnih karakterističnih predmeta. Naše trenutne spoznaje o položaju i ulozi žena većinom potječu iz istraživanja groblja koja nude prilično točnu sliku o svakodnevnom životu ŽD zajednica. Za vrijeme ŽD u KK uobičajeno je kako su pokojnice bile pokopane u svakodnevnoj nošnji i s osobnim nakitom koji se, s nalazima pršljena, smatraju kao iznimno jasan rodni prikaz. Projekt predstavlja kompleksnu studiju poznatih ŽD ženskih pokopa sa šest groblja u promatranom području na osnovi roda, dobi i grobnih priloga koje mogu obogatiti naše spoznaje o ŽD društvu na mnogo načina, pri čemu se posebna pažnja posvećuje funkcionalnoj analizi kombinacija u grobovima koje prikazuju različite lokalne ŽD zajednice te  višestruke identiteta jedne osobe. Funkcionalna analiza, odnosno kako su različiti elementi nošnje i nakita organizirani i udruženi u različite kombinacije, pruža pouzdane podatke o načinima koje su različiti pojedinci i/ili zajednice odabirali kako bi vizualno prikazali vlastite identitete i društvene odnose.]]></summary_hr><summary_en><![CDATA[Aim of proposed Iron Age project, conducted by archaeology in collaboration with anthropological and archaeometallurgical researches, is emphasis placed on the study of different aspects of the Iron Age (IA) female social identities which only can be reconstructed from the archaeological records. In this project is planning to explore common models, with the use of current interdisciplinary possibilities, in the field of gender concept which will be innovative activity and significant improvements in exploring of IA communities in the southern Carpathian Basin (CB). Female identity is composed of multiple features that are connected together to create an individual personhood. During a lifetime an individual has various social identities, even several at the same time. Females during the IA in the southern CB become increasingly visible in the archaeological record through the development of numerous characteristic accessories. Our present knowledge about position and role of women comes mostly from cemeteries which offer a fairly accurate picture of the everyday life of the IA communities. During the IA in the CB was a standard for the deceased to be buried in the everyday costume and with personal jewellery which, with spindle whorls, are remarkably sharp gender outfits. A project represent a complex study of the known IA female burials from six cemeteries in define region in terms of gender, age and grave goods which can enrich our knowledge of the IA society in many ways, with special attention to the functional analysis of the grave assemblages which reflects different local IA communities and shared identities of single persons. Functional analysis, the manner in which different costume and jewellery elements are composed and associated in various assemblages, provides relevant information regarding the ways in which various individuals and/or different communities chose to visually express their identities and social relationships.]]></summary_en></project><project>
<id>4352</id><title_hr><![CDATA[Cas3 kao kontrolna točka obrane CRISPR-Cas: razjašnjenje  njegove regulacije istraživanjem stabilnosti proteina i prepisivanja u bakteriji Escherichia coli]]></title_hr><title_en><![CDATA[Cas3 as a key checkpoint for CRISPR-Cas immunity: elucidating its regulation via protein stability and transcriptional control in Escherichia coli]]></title_en><user_id>4503</user_id><user_firstLast_name>Ivana Ivančić Baće</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-8861</code><acronim><![CDATA[Cas3 status]]></acronim><duration>01.03.2017 - 31.08.2021</duration><status>Završio</status><financ_value>125.091,25 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, Kemija, </scie_field_hr><scie_field_en>Biology, Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>19376, 5173, 22812, 25303, </team_members_id><team_members_names><![CDATA[Kristina Majsec, Edward  Bolt Bolt, Marin Radovčić, Damjan Mitić, ]]></team_members_names><keywords_hr><![CDATA[CRISPR-Cas, Cas3, E. coli, RecBCD, HNS]]></keywords_hr><keywords_en><![CDATA[CRISPR-Cas, Cas3, E. coli, RecBCD, HNS]]></keywords_en><summary_hr><![CDATA[Clustered regularly interspaced short palindromic repeats (CRISPR) i CRISPR-associated (Cas) proteini sačinjavaju adaptivni imunološki sustav bakterija i arheja u borbi protiv virusa i plazmida. Ovaj sustav temelji se na ugradnji kratkih fragmenata strane DNA (razmaknice) u regiju CRISPR procesom koji se zove adaptacija. Ugrađene razmaknice služe za pamćenje prethodnih infekcija. U bakteriji Escherichia coli poznata su dva načina adaptacije: naivna i pripremljena. Tijekom naivne adaptacije razmaknice se direktno uzimaju iz strane DNA, dok je u pripremljenoj adaptaciji neophodna već postojeća razmaknica koja stimulira ugradnju novih razmaknica iz iste strane DNA. Za oba načina adaptacije neophodni su proteini Cas1 i Cas2, dok su za pripremljenu adaptaciju još potrebni interferencijski kompleks Cascade i protein Cas3. Unatoč značajnom napretku u otkriću molekularnih mehanizama obrane sustavom CRISPR-Cas, detalji nastanka dvolančanih fragmenata DNA potrebnih za oba načina adaptacije nisu dovoljno poznati, a također je nedovoljno istražena i regulacija CRISPR-Cas interferencije. Za RecBCD smo mi i drugi pokazali da je potreban za pripremu i ugradnju razmaknice u naivnoj adaptaciji, a nedavno smo pokazali da je protein Cas3 ograničavajući faktor CRISPR-Cas interferencije u ovisnosti o temperaturi inkubiranja. To upućuje na mogućnost da postoji još jedna razina regulacije sustava CRISPR-Cas u bakteriji E. coli koju bismo željeli istražiti. Da bismo doznali više o proteinu Cas3, razlozima njegove neobične aktivnosti i ulogama u CRISPR-Cas adaptivnoj imunosti, ciljevi ovog projekta su a) razjasniti je li protein Cas3 reguliran na razini transkripcije i post-translacijski. b) Istražiti uloge proteina Cas3 i komponenti enzima RecBCD u izgradnji CRISPR imunosti (adaptaciji). Također bismo željeli istražiti jesu li uloge ovih proteina međusobno usklađene i povezane s drugim staničnim procesima uključenim u održavanje stabilnosti genoma.]]></summary_hr><summary_en><![CDATA[Clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated (Cas) proteins constitutes an adaptive immune system in bacteria and archaea against viruses and plasmids. It is based on integration of short fragments of foreign DNA (spacers) into the CRISPR array in a process called adaptation that serves as a memory of prior infections. Two modes of adaptation have been reported in Escherichia coli type IE system: naive and primed. During the naive adaptation, the spacers are directly obtained from a foreign DNA source while in primed adaptation the pre-existing spacer is required to enable enhanced uptake of new spacers from the same foreign DNA. Both modes require Cas1 and Cas2 proteins, and primed adaptation additionally requires interference complex Cascade and Cas3 protein. Despite the significant progress on the molecular mechanisms of defence by the CRISPR-Cas systems, details about generation of DNA fragments needed for both modes of adaptation are not sufficiently known, or mechanisms of the regulation of the CRISPR-Cas interference. We and others have recently shown that RecBCD enzyme is involved in spacer preparation and integration for naive adaptation, and we have very recently shown that Cas3 is the limiting factor for CRISPR-Cas interference depending on the temperature of incubation. This suggests a possibility that additional level of regulation of the CRISPR-Cas interference exists in E. coli. To learn more about the Cas3 protein, explain its unusual activity and find out about its roles in CRISPR-Cas adaptive immunity, the aims of this project are a) to understand if Cas3 is regulated in E. coli transcriptionally and post-translationally. (b) Delineate the roles of RecB and RecBC components of RecBCD and Cas3 protein in building CRISPR immunity (adaptation). We would also like to understand if their roles are coordinated and linked to other host cell genome maintenance processes.]]></summary_en></project><project>
<id>4355</id><title_hr><![CDATA[Rasvjetljivanje onkogenih funkcija E6/E7 HPV-a na različitim anatomskim mjestima ]]></title_hr><title_en><![CDATA[Elucidating the HPV E6/E7 Oncogenic Functions at Different Anatomical Sites]]></title_en><user_id>15915</user_id><user_firstLast_name>Vjekoslav Tomaić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-2246</code><acronim><![CDATA[HPVHNC]]></acronim><duration>15.05.2017 - 14.05.2022</duration><status>Završio</status><financ_value>131.661,03 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>3627, 19310, 19200, 19168, 3949, 25278, 23946, 24275, 24996, 17772, </team_members_id><team_members_names><![CDATA[Jasminka Golubić Talić, Lawrence Banks, Miranda Thomas, Paola Massimi, Emil Dediol, Lucija Lulić, Dražan Butorac, Nathaniel Edward Bennett Saidu, Anamaria Đukić, Josipa Skelin, ]]></team_members_names><keywords_hr><![CDATA[HPV, Karcinom, Glava i Vrat, E6, E7]]></keywords_hr><keywords_en><![CDATA[HPV, Cancer, Head and Neck, E6, E7 ]]></keywords_en><summary_hr><![CDATA[Humani papiloma virusi (HPV) uzrokuju preko 600.000 novih slučajeva raka godišnje na različitim anatomskim mjestima. Najčešća sijela raka uzrokovanog HPV-om su anogenitalno područje te glava i vrat. Najvažniji tip tumora uzrokovan HPV-om je rak vrata maternice, koji je jedan od glavnih uzroka smrti od tumora žena diljem svijeta. HPV-i kodiraju dva onkoproteina, E6 i E7 koji su direktno odgovorni za tumorigenezu. Ovi onkoproteini ciljaju različite signalne puteve stanice domaćina vezane uz kontrolu staničnog ciklusa i apoptozu te su trajno potrebni za proces tumorigeneze. Ukoliko se bilo koji od njih prestane ispoljavati, dolazi do prestanka rasta transformiranih stanica. Stoga ovi proteini predstavljaju značajne mete za eventualne terapije, a detaljno razumijevanje molekularnih mehanizama njihovog funkcioniranja je od iznimne važnosti. U zadnjih nekoliko godina je zamijećen trend porasta učestalosti nekih od HPV-povezanih tipova tumora, pogotovo u regiji glave i vrata. Ovi tumori većinom sadrže HPV tip 16, a karakterizira ih relativno kraće vrijeme između infekcije i nastanka tumora u odnosu na anogenitalne tumore. Ovo upućuje na postojanje značajnih razlika u mehanizmima nastanka tumora na različitim anatomskim mjestima. Jedan od glavnih ciljeva ovog projekta će biti otkriti da li su spomenute razlike posljedica različitih interakcija virusa i domaćina u različitim anatomskim mjestima. ]]></summary_hr><summary_en><![CDATA[Human Papillomaviruses (HPVs) cause over 600,000 cancers annually. These occur at diverse anatomical sites, and include anogenital and head and neck (HN) cancers. Of these the most important is cervical cancer, which is the leading cause of cancer-related death in women in many parts of the world. HPVs encode two oncoproteins, E6 and E7 that are directly responsible for the development of HPV-induced malignancies. They do this cooperatively by targeting diverse cellular pathways involved in the regulation of cell cycle control and apoptosis. Most importantly, there is a continued requirement for E6 and E7 expression throughout tumourigenesis, with loss of either protein resulting in a cessation of transformed cell growth. Therefore these viral proteins represent excellent targets for therapeutic intervention and understanding the molecular mechanisms underlying their respective functions is critical for developing such antiviral therapies. In recent years there has been dramatic increase in the number of HPV-associated cancers at other anatomical sites, especially in the HN region. Cancers found in this area largely contain HPV-16 sequences and the time frame between initial infections and cancer progression is much shorter in comparison with the anogenital cancers, indicating potentially major differences in how these viruses induce cancer development at different anatomical sites. Determining if this is a reflection of different modes of virus-host interactions in these sites will be the main focus of this project.]]></summary_en></project><project>
<id>4361</id><title_hr><![CDATA[Istraživanje složenih multiferoičnih materijala pripravljenih metodama otopinske kemije ]]></title_hr><title_en><![CDATA[Solution chemistry routes towards complex multiferroic materials]]></title_en><user_id>11136</user_id><user_firstLast_name>Igor Đerđ</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-3115</code><acronim><![CDATA[SOLFERROMAT]]></acronim><duration>01.03.2017 - 31.10.2021</duration><status>Završio</status><financ_value>129.802,91 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, Fizika, </scie_field_hr><scie_field_en>Chemistry, Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Odjel za kemiju]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Department of Chemistry]]></institution_en><team_members_id>3671, 3960, 13203, 3531, 2757, 19878, 3632, 19928, 25200, </team_members_id><team_members_names><![CDATA[Goran Štefanić, BERISLAV MARKOVIĆ, Brunislav Matasović, Tomislav Balić, Dajana Gašo-Sokač, Mirjana  Bijelić, Anamarija šTER, Zvonko Jagličić, Jelena Bijelić, ]]></team_members_names><keywords_hr><![CDATA[Multiferoici, telurati, volframati, metaloorganske mreže, struktura]]></keywords_hr><keywords_en><![CDATA[Multiferroics, Tellurates, Tungstates, Metal-organic framework, Structure]]></keywords_en><summary_hr><![CDATA[Kako su i feromagnetizam i feroelektricitet ključni u mnogim aspektima moderne tehnologije, zahtjevi za materijalima koji pokazuju oba svojstva predstavljaju značajnu fundamentalnu i tehnološku važnost. Ipak, kad se u jednofaznom materijalu pojavljuje dva ili više fero-uređenja, njihovo međudjelovanje može proizvesti novi učinak koji se manifestira kao električna polarizacija uslijed primjene magnetskoga polja ili, obratno, magnetizacija uslijed primjene električnog polja.Glavni je cilj projekta SOLFERROMAT dizajniranje tri nova tipa funkcionalnih multiferoičnih spojeva: i) metaloorganskih spojeva perovskitne strukture ABX3 (A = amin-kation, B = prijelazni metal, X = organski ligand)ii) hibridne organsko-anorganske perovskitne strukture ABX4 (A = amin-kation, B = prijelazni metal, X = halogeni element) iiii) kompleksnih dvostrukih ili pojedinačnih perovskita tipa A2B(Te/W)O6 ili A3B2(Te/W)O9 (A = laki dvovalentni metal, B = prijelazni metal).Principi moderne koordinacijske kemije koji uključuju sol-gel postupak, mehanokemiju i mehanokemiju potpomognutu otapalom bit će korišteni za dizajniranje novih materijala za pohranu podataka, poglavito za  spintronske uređaje. Pažljivo organizirani slijed sinteza, karakterizacija i mjerenja magnetskih, električnih i magnetoelektričnih svojstava omogućit će postizanje ovoga cilja.Predložena metodologija za karakterizaciju struktura i svojstava novih materijala jest sinergija tehnika korištenih u trima disciplinama: koordinacijskoj kemiji, fizici kondenzirane tvari i znanosti o materijalima.  Glavni je cilj projekta poboljšati istraživanje povezivanjem kristalnog inženjeringa s fizikom i kemijom materijala kako bi se otkrili materijali novih funkcionalnih multiferoičnih svojstava. ]]></summary_hr><summary_en><![CDATA[Since indeed both ferromagnetism and ferroelectricity are essential to many forms of modern technology the demand for materials displaying both properties is of a great fundamental and technological importance, however, when coexistence of two or more ferroic orders in single-phase material is found, and furthermore, intimately coupled, the coupling interaction could produce new effect which manifests itself as an appearance of an electric polarization upon applying a magnetic field, and the appearance of magnetization upon applying an electric field. The main objective of SOLFERROMAT proposal is the design of three novel types of functional multiferroic compounds: i) perovskite structured metal-organic frameworks ABX3 (A = amine cation, B = transition metal, X = organic ligand) ii) perovskite-like hybrid organic-inorganic structures ABX4 (A = amine cation, B= transition metal, X = halogen) and iii) complex double or single perovskites A2B(Te/W)O6 or A3B2(Te/W)O9 (A = light divalent metal, B = transition metal). Building principles of modern coordination chemistry including sol-gel route, mechanochemistry and solvent assisted mechanochemistry will be actively used to explore the fundamental potential of designing new solids for data storage, particularly for spintronic devices. Carefully organized sequence of synthesis, characterization, and magnetic, electric and magnetoelectric properties measurements will allow achieving this goal.The proposed methodology to characterize structure and properties of new materials is the synergy of techniques used in three disciplines: coordination chemistry, condensed matter physics and materials science. The main aim of the project is to enlarge research by introducing crystal engineering into the physics and chemistry of solids, in order to reveal materials with new functional multiferroic properties.]]></summary_en></project><project>
<id>4362</id><title_hr><![CDATA[Istraživanje uloge proteinske modifikacije ADP-ribozilacije kod bakterija]]></title_hr><title_en><![CDATA[Understanding the role of protein ADP-ribosylation modification in bacteria]]></title_en><user_id>1221</user_id><user_firstLast_name>Andreja Mikoč</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-4242</code><acronim><![CDATA[ADPRIBAC]]></acronim><duration>01.03.2017 - 30.09.2021</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>1193, 1208, 1225, 19653, 23286, 27438, </team_members_id><team_members_names><![CDATA[Helena Ćetković, Mirna Halasz, Bruna Pleše, Ivan Ahel, Petra Mikolčević, Andrea  Hloušek-Kasun, ]]></team_members_names><keywords_hr><![CDATA[ADP-ribozilacija, streptomiceti, antibiotici, ADP-ribozil-transferaze, ADP-ribozil-hidrolaze,  makrodomene]]></keywords_hr><keywords_en><![CDATA[ADP-ribosylation, Streptomyces, antibiotics, ADP-ribosyltransferases, ADP-ribosylhydrolases, macrodomains ]]></keywords_en><summary_hr><![CDATA[Post-translacijske modifikacije događaju se nakon biosinteze proteina, mijenjaju svojstva proteina te proširuju njihov funkcionalni repertoar i regulaciju. ADP-ribozilacija proteina je reverzibilna post-translacijska modifikacija u kojoj se adenozin difosfat (ADP)-ribozni dio iz nikotinamid-adenin-dinukleotida (NAD) prenosi na ciljni protein. To je evolucijski očuvan proces koji kontrolira važne stanične procese kod eukariota. ADP-ribozilacija je otkrivena i kod nekoliko vrsta bakterija, ali su njezina regulacija i fiziološka važnost kod bakterija vrlo slabo istražene. Trenutno dostupni podaci ukazuju na to da ADP-ribozilacija sudjeluje u regulaciji proizvodnje antibiotika u modelnoj bakteriji iz roda Streptomyces, S. coelicolor. Streptomiceti su uobičajene bakterije tla poznate kao glavni proizvođači velikog broja različitih prirodnih bioaktivnih spojeva, posebno antibiotika.U okviru ovog projekta ćemo identificirati i opisati proteine odgovorne za stavljanje i skidanje proteinske modifikacije ADP-ribozilacije kod bakterije S. coelicolor i razjasniti stanične i metaboličke putove koje ova modifikacija kontrolira. Razumijevanje procesa ADP-ribozilacije kod streptomiceta trebalo bi nam omogućiti bolju manipulaciju i kontrolu metabolizma kod ovih iznimno važnih industrijskih mikroorganizama. Zbog očuvanosti proteina uključenih u proces ADP-ribozilacije, nove spoznaje do kojih dođemo kroz ovaj projekt trebale bi biti primjenjive i na druge bakterijske vrste, a u nekim aspektima potencijalno i na ljude.]]></summary_hr><summary_en><![CDATA[Post-translational modifications of proteins are chemical modifications of proteins that happen after their biosynthesis. They control behavior of the proteins and expand their functional repertoire and regulation. Protein ADP-ribosylation is a reversible post-translational modification in which an adenosine diphosphate (ADP)-ribose moiety from nicotinamide adenine dinucleotide (NAD) is transferred to a target protein. This is an ancient and ubiquitous process which controls wide variety of important cellular functions in eukaryotes. ADP-ribosylation has been detected in several bacterial species, but its regulation and physiological relevance are very poorly understood in bacteria. Currently available data suggest that ADP-ribosylation is involved in regulation of antibiotic production in a model bacterium from Streptomyces genus, S. coelicolor. Streptomyces are common soil bacteria particularly important as the main natural producers of diverse bioactive compounds, especially antibiotics.In the framework of this project we will identify and characterize novel proteins that make and remove the protein ADP-ribosylation in S. coelicolor and elucidate its cellular and metabolic pathways controlled by this modification. Understanding this process in Streptomyces should enable us to improve manipulations and control metabolism of these extremely important industrial microorganisms. Due to the conservation of proteins involved in ADP-ribosylation process, the knowledge obtained through this project should be translatable to other bacterial species, but in some aspects also possibly to humans.]]></summary_en></project><project>
<id>4365</id><title_hr><![CDATA[EVOLUCIJA UPALNOG ARTRITISA U DJECE: ULOGA OSNAŽENOGA MUSKULOSKELETNOGA ULTRAZVUKA TE EPIGENETSKIH, PROTEINSKIH I DISBIOTIČKIH BIOMARKERA U RAZVOJU JUVENILNOG IDIOPATSKOG ARTRITISA]]></title_hr><title_en><![CDATA[EVOLUTION OF INFLAMMATORY ARTHRITIS IN CHILDREN: THE ROLE OF PDUS ASSESMENT AND EPIGENETIC, PROTEIN AND DYSBIOSIS BIOMARKERS IN JUVENILE IDIOPATHIC ARTHRITIS DEVELOPEMENT]]></title_en><user_id>4768</user_id><user_firstLast_name>Miroslav Harjaček</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-4771</code><acronim><![CDATA[childARTHRITISevolve]]></acronim><duration>01.04.2017 - 31.03.2021</duration><status>Prekinut</status><financ_value>119.175,23 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Kliničke medicinske znanosti, Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Clinical sciences, Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Klinički bolnički centar "Sestre Milosrdnice", Zagreb]]></institution_hr><institution_en><![CDATA[Clinical Hospital Center "Sestre Milosrdnice", Zagreb]]></institution_en><team_members_id>13667, 2978, 13115, 20080, 20296, 20204, 25390, </team_members_id><team_members_names><![CDATA[Lovro Lamot, Vedran Katavić, Andrea Tešija Kuna, Danica Vidović Juras, Suzana Ožanić Bulić, Mandica Vidović, Domagoj Buljan, ]]></team_members_names><keywords_hr><![CDATA[juvenilni idiopatski artritis, nediferencirani artritis, epigenetika, proteomika, disbioza, ultrazvuk, biomarkeri]]></keywords_hr><keywords_en><![CDATA[juvenile idiopathic arthritis, undifferentiated arthritis, epigenetics, proteomics, dysbiosis, ultrasound, biomarkers]]></keywords_en><summary_hr><![CDATA[Juvenilni idiopatski artritis (JIA) najčešća je reumatska bolest dječje dobi. Kako bi se spriječilo oštećenje zglobova te razvoj funkcionalne nesposobnosti, jedan od glavnih ciljeva u liječenju bolesti postao je rano postavljanje dijagnoze te odabir učinkovite i poštedne terapije. Nažalost, na samom početku bolesti trenutno je vrlo teško odrediti kako će bolest napredovati. Dosada je provedeno mnogo istraživanja koja su pokazala da u podlozi bolesti leži kompleksna disregulacija imunološkog sustava do koje dolazi zbog utjecaja genetskih i okolišnih čimbenika. Ipak, još smo daleko od jasne slike mehanizama koji predisponiraju dijete za razvoj bolesti, pogoršanje simptoma ili za dobar odgovor na pojedini oblik liječenja. Cilj ovoga projekta stoga je u krvi, stolici, slini i sinovijalnoj tekućini bolesnika otkriti različite epigenetske i proteinske biomarkere te odrediti vrijednost osnaženog muskuloskeletnog ultrazvuka (engl. power-doppler ultrasound) i različitih kliničkih pokazatelja u otkrivanju ranih promjena i predviđanju tijeka bolesti. U istraživanju će sudjelovati 17 bolesnika s nediferenciranim artritisom (NA) i 33 bolesnika s razvijenim JIA koji će biti praćeni tijekom dvije godine. U više vremenskih točaka ispitat će se epigenetski mehanizmi (metilacija, histonska modifikacija) regulacije ključnih čimbenika transkripcije i fosfataza koji se povezuju s razvojem bolesti te izražaj nekodirajućih RNA. Nadalje, u više navrata će se provesti i analize proteoma pomoću masene spektometrije, a odabrani proteini analizirati će se pomoću komplementarnih metoda. Rezultati ovog sveobuhvatnog projekta pružit će nam bolji uvid u kompleksne mehanizme u podlozi bolesti te otkriti potencijalne epigenetske, proteinske i disbiotičke biomarkere koji će nam omogućiti ranije postavljanje dijagnoze te bolje klasificiranje bolesti i predviđanje odgovora na liječenja. Naposljetku, dobiveni rezultati mogli bi nam omogućiti i otkrivanje novih načina liječenja ove nepredvidive bolesti.]]></summary_hr><summary_en><![CDATA[Juvenile idiopathic arthritis (JIA) is the most common childhood rheumatic disease. The early diagnosis of new-onset JIA has become a major objective for pediatric rheumatologists in order to identify a management strategy able to change the natural history of the disease and to prevent joint damage and functional impairment. The term undifferentiated arthritis (UA) is applied to the most common type of arthritis at the early stage when, in the absence of current recommended diagnostic criteria, it cannot be classified into the clinical subtypes of JIA. Patients with UA may progress towards JIA; however in some cases arthritis may completely resolve. Many studies has shown important role of immune system dysregulation influenced by genetic and environmental factors, but we are still far from having a clear picture of the molecular network that predisposes a child to develop the disease, to worsen the symptoms, or to successfully respond to a specific treatment. The goal of this project is to identify various epigenetic, protein and dysbiotic biomarkers in blood, stool, saliva and synovial fluid of 17 UA and 33 JIA patients, along with the value of power-doppler ultrasound (PDUS) and clinical assessment tools in the prediction of disease evolution. Therefore, we will analyze epigenetic modifications (methilatyon and histone modifications) of transcription factors and phosphatases with a known role in disease development, as well as microRNA expression profiles. Furthermore, to elucidate the possible role of other proteins, proteome will be analyzed by mass spectrometry, and selected proteins will be confirmed by complementary methods. The results of this comprehensive project will provide new insights into complex pathophysiology of JIA and enable us to use epigenetic, protein and dysbiotic biomarkers for better diagnosis, classification and treatment response prediction. In addition, results of the project may help to identify potentially new therapeutic targets.]]></summary_en></project><project>
<id>4369</id><title_hr><![CDATA[Molekularni mehanizam neurodegeneracije u Niemann-Pickovoj bolesti tip C]]></title_hr><title_en><![CDATA[Molecular mechanism(s) of neurodegeneration in Niemann-Pick type C disease]]></title_en><user_id>4828</user_id><user_firstLast_name>Silva Katušić Hećimović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-2799</code><acronim><![CDATA[neuroNiPiC]]></acronim><duration>01.06.2017 - 30.04.2022</duration><status>Završio</status><financ_value>127.679,34 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>19545, 19703, 19821, 17865, 25337, 25281, 3095, </team_members_id><team_members_names><![CDATA[Sabina Tahirovic, Alessio Vittorio Colombo, Stefan  Lichtenthaler, Kristina Dominko, Lea Vidatić, Ana Rastija, Martina Deželjin, ]]></team_members_names><keywords_hr><![CDATA[Alzheimerova bolest, Aß, APP, BACE1, kolesterol, neurodegeneracija, neuroinflamacija, Niemann-Pickova bolest tip C, NPC1, tau]]></keywords_hr><keywords_en><![CDATA[Alzheimer’s disease, Aß, APP, BACE1, cholesterol, neurodegeneration, neuroinflammation, Niemann-Pick type C disease, NPC1, tau]]></keywords_en><summary_hr><![CDATA[Niemann-Pickova bolest tip C (NPC) je rijetka dječja progresivna neurodegenerativna bolest koju karakterizira nakupljanje kolesterola, gubitak Purkinjeovih neurona u cerebelumu, hiperfosforilacija proteina tau i značajna neuroinflamacija. Intrigantno je da ova rijetka nasljedna bolest (uzrokovana mutacijama u genu NPC1 ili NPC2) pokazuje niz značajki kompleksne Alzheimerove bolesti (AB). Međutim, ove neurodegenerativne bolesti pokazuju različitu „ranjivost“ regija mozga; hipokampus je primarno oštećen u AB, dok je pošteđen u bolesti NPC, a cerebelum je pošteđen u AB, dok je primarno zahvaćen u bolesti NPC. U ovom projektu ćemo primijeniti saznanja opsežnih istraživanja proteolitičke razgradnje proteina prekursora peptida amiloid-ß (APP) u najčešćoj neurodegenerativnoj bolesti AB s ciljem razumijevanja molekularnog mehanizam neurodegeneracije u rijetkoj bolesti NPC. Potaknuti našim nedavnim otkrićem da jedan od glavnih enzima AB ß-sekretaza (BACE1) povećano cijepa protein APP u bolesti NPC, ispitat ćemo ulogu proteolize enzimom BACE1 u patogenezi bolesti NPC i može li BACE1 predstavljati novu ciljnu molekulu za tretiranje/ublažavanje bolesti NPC. U hipokampusu i cerebelumu NPC1- i wt-miševa ispitat ćemo proteolizu i distribuciju APP kao i dva nedavno otkrivena isključiva supstrata za BACE1. Primarne kulture neurona hipokampusa i Purkinjeovih neurona cerebeluma ćemo upotrijebiti za otkrivanje mehanizma učinka BACE1 na patološke značajke NPC bolesti. Također, razvit ćemo ex vivo model bolesti NPC korištenjem organotipskih kultura moždanih rezova hipokampusa i cerebeluma te ćemo pratiti utjecaj inhibicije BACE1 na prevenciju/ublažavanje patoloških značajki bolesti NPC. Konačno, generirat ćemo mišji model NPC1 u kojem ćemo ukloniti gen BACE1 za potvrdu dobivenih rezultata in vivo. Ova istraživanja će ukazati na ulogu BACE1 u patogenezi NPC bolesti i na potencijalno ciljanje enzima BACE1 kao alternativnog pristupa liječenja ove još uvijek neizlječive bolesti.]]></summary_hr><summary_en><![CDATA[Niemann-Pick type C disease (NPC) is a rare childhood progressive neurodegenerative disorder characterized by cholesterol accumulation, the loss of Purkinje neurons in the cerebellum, hyperphosphorylation of tau and profound neuroinflammation. It is intriguing that this rare inherited disease (caused by mutations in NPC1 or NPC2 genes) shows several key features of a complex Alzheimer&#39;s disease (AD). However, these two neurodegenerative disorders show different regional vulnerabilities; hippocampus is the most affected region in AD and is spared in NPC disease, and the cerebellum is spared in AD but is primarily affected in NPC. In this project we will use the knowledge gained through extensive research on the processing of the ß-amyloid precursor protein (APP) in the most common neurodegenerative disease AD to elucidate molecular mechanism(s) of neurodegeneration in a rare disorder NPC. Based on our recent finding that proteolysis of APP by one of the key AD enzymes ß-secretase (BACE1) is enhanced in NPC, in this project we will elucidate the role of BACE1 in the pathogenesis of NPC and whether BACE1 may represent a novel target for treating/ameliorating NPC disease. We will analyze BACE1-proteolysis and distribution of APP and the two recently identified exclusive BACE1 substrates in hippocampus and cerebellum of NPC1- and wt-mice. Primary hippocampal and cerebellar Purkinje neuronal cultures will be used to dissect the mechanism(s) of the BACE1-mediated effect on pathological features of NPC. Also, we will develop an ex vivo model of NPC disease using hippocampal and cerebellar organotypic brain slices and will monitor whether BACE1-inhibition may prevent/ameliorate any of the NPC pathological features. Lastly, we will genetically deplete BACE1 in NPC1-mice to validate our findings in vivo. These studies may indicate a role of BACE1 in NPC pathogenesis and the potential of targeting BACE1 as an alternative approach for treating this devastating disease.]]></summary_en></project><project>
<id>4372</id><title_hr><![CDATA[Tipovi školske kulture i  učenje aktivnog građanstva: kritičko-interdisciplinarni pristup]]></title_hr><title_en><![CDATA[The Types of School Culture and Learning for Active Citizenship: Critical Interdisciplinary Approach]]></title_en><user_id>7887</user_id><user_firstLast_name>Vedrana Spajić-Vrkaš</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-5010</code><acronim><![CDATA[TaSC]]></acronim><duration>01.01.2017 - 31.12.2020</duration><status>Prekinut</status><financ_value>68.153,16 eur</financ_value><scie_area_hr>Društvene znanosti, Humanističke znanosti, </scie_area_hr><scie_area_en>Social sciences, Humanities, </scie_area_en><scie_field_hr>Pedagogija, Politologija, Sociologija, Etnologija i antropologija, Obrazovne znanosti, </scie_field_hr><scie_field_en>Pedagogy, Political Science, Sociology, Ethnology and anthropology, Educational sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>12964, 13252, 12864, 13233, 12830, 12926, 12924, 13059, 6817, 7274, 13048, 13103, 13579, 19948, </team_members_id><team_members_names><![CDATA[Elvi Piršl, Barbara Kušević, Ana Širanović, Neven Hrvatić, Ana Blažević Simić, Marija Bartulović, Tomislav Pletenac, Monika Rajković, Marija Sablić, Berto  Šalaj, Dorijan Vahtar, Izvor Rukavina, Benjamin Čulig, Ines Elezović, ]]></team_members_names><keywords_hr><![CDATA[tipovi kulture škole, učenje aktivnog građanstva, kritičko-interdisciplinarni pristup, kvantitativno istraživanje, kvalitativno istraživanje]]></keywords_hr><keywords_en><![CDATA[types of school culture, learning for active citizenship, critical interdisciplinary approach, quantitative research, qualitative research]]></keywords_en><summary_hr><![CDATA[Usprkos općem prihvaćanju teze da je pripremljenost građana za participaciju ključ demokratskog razvoja kao i domaćim istraživanjima koja potvrđuju nisku razinu političkog znanja i kulture učenika, hrvatske škole ni danas ne pripremaju za aktivno građanstvo. Inozemna iskustva potvrđuju da je takva priprema dugotrajan i složen proces čiji uspjeh ne ovisi samo o uvođenju građanskog obrazovanja u škole nego i o demokratičnosti školske kulture. O tome u velikoj mjeri ovisi hoće li učenici učiti o građanstvu ili za građanstvo i hoće li građansku ulogu shvaćati u terminima poslušnosti i dužnosti ili emancipacije i društvene odgovornosti. Međutim, povećanje interesa za to područje nije dovelo i do većeg broja odgovarajućih istraživanja, i to zato što se metodologija istraživanja školske kulture razvila iz teorije akademske učinkovitosti škole, kojoj se zamjera promicanje antidemokratskih školskih praksi. Suočeni s tim nedostacima, skupina hrvatskih istraživača izradila je instrument za ispitivanje percepcije školske kulture i došla do njihove tipologije po kriteriju demokratsko-nedemokratsko. S obzirom da ranija istraživanja nisu eksplicitno propitivala ulogu školske kulture u razvoju aktivnog građanstva, u ovom je projektu postavljen trostruki cilj: a. utvrditi koja obilježja školske kulture doprinose razvoju aktivnog građanstva; b. utvrditi jesu li ta obilježja međupovezana i strukturirana tako da vode izradi tipologije koja odgovara na pitanje zašto se neke škole uspijevaju a druge ne uspijevaju demokratizirati i c. predložiti kritičko-transformativni model demokratske školske kulture. Istraživanje će se provoditi u dvije faze. U prvoj, kvantitativnoj, primijenit će se anketni upitnici na reprezentativnom uzorku glavnih aktera obrazovanja. U drugoj, kvalitativnoj, pratit će se i opisati obilježja uspješne i neuspješne škole. Analiza i interpretacija bit će provedene prema standardima kritičko-interdisciplinarne perspektive. ]]></summary_hr><summary_en><![CDATA[Despite the generally accepted thesis that the preparation of citizens for participation is the key to developing democracy, and despite domestic studies that show a low level of students’ political knowledge and culture, Croatian schools do not prepare for active citizenship. Foreign experiences confirm that such preparation is a long-lasting and complex process. Its success does not depend solely on the introduction of citizenship education in schools but also on the democratization of school culture. This depends on whether the students will learn about or for citizenship and whether they will understand their citizen’s role in terms of obedience and duties or in terms of emancipation and social responsibility. However, the rise of interest in this field did not lead to more such studies, due to the research methodology based on academic school effectiveness theory, often criticized for promoting undemocratic school practices. Faced with such limitations, a group of Croatian researchers developed an instrument for studying school culture, which led to a school culture typology placed on the democratic-undemocratic continuum. Since earlier studies were not focused on the link between school culture and active citizenship, the present research has a three-fold goal: a. to identify the characteristics of school culture contributing to the development of active citizenship; b. to determine whether these characteristics are inter-linked and structured so as to allow the development of a typology to explain why some schools succeed and other fail to democratize, and c. to develop a critical transformative model of a democratic school culture. Research will be conducted in two phases: quantitative, in which questionnaires will be applied on a representative sample of main school actors, and qualitative, in which successful and unsuccessful school culture features will]]></summary_en></project><project>
<id>4377</id><title_hr><![CDATA[Zaštitni mehanizmi i učinci flavonoida ugrađenih u nanonosače u modelnim membranama i neuronima]]></title_hr><title_en><![CDATA[Protective mechanisms and effects of nano-delivered flavonoids in model cell membranes and neurons]]></title_en><user_id>423</user_id><user_firstLast_name>Suzana Šegota</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-8415</code><acronim><![CDATA[NanoFlavNeuroProtect]]></acronim><duration>15.04.2017 - 14.10.2021</duration><status>Završio</status><financ_value>126.875,04 eur</financ_value><scie_area_hr>Prirodne znanosti, Biomedicina i zdravstvo, </scie_area_hr><scie_area_en>Natural sciences, Biomedicine and health sciences, </scie_area_en><scie_field_hr>Biotehnologija u biomedicini, Kemija, Biologija, </scie_field_hr><scie_field_en>Biotechnology in Biomedicine, Chemistry, Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>224, 339, 404, 336, 771, 5101, 3616, 19218, 25279, 25592, </team_members_id><team_members_names><![CDATA[Maja Dutour Sikirić, Darija Domazet Jurašin, Vida Čadež, Tea Mihelj, Goran Baranović, Josipa Vlainić, Martina Medvidović-Kosanović, Mislav Mustapic, Anja Sadžak, Lucija Mandić, ]]></team_members_names><keywords_hr><![CDATA[mikroskopija atomskih sila, modelne membrane, flavonoidi, nanočestice, neuroni, oksidativni stres, neurozaštita]]></keywords_hr><keywords_en><![CDATA[atomic force microscopy, model membranes, flavonoids, nanoparticles, neurons,  oxidative stress, neuroprotection]]></keywords_en><summary_hr><![CDATA[Flavonoidi, polifenolne biomolekule s antioksidativnom aktivnošću prepoznate su kao potencijalno novi terapeutici neurodegenerativnih bolesti. Osim što mehanizam antioksidativnog učinka flavonoida do danas nije u potpunosti razjašnjen, mogućnosti njihove terapeutske primjene smanjuje i slaba topljivost u vodi te kemijska nestabilnost pri fiziološkim uvjetima, koja se javlja prilikom primjene farmaceutskih proizvoda. Moguće rješenje je ugradnja flavonoida u nanočestice (NČ) kao nosače. Cilj predloženog projekta je riješiti problem slabe topljivosti u vodi i kemijske nestabilnosti dostavom flavonoida ugrađenih u NČ do modelnih membrana i neurona, čime bi se trebali poboljšati njihovi zaštitni učinci. Kako bi potvrdili primjenjivost ovog pristupa, u sklopu predloženog projekta istražit će se i interakcije između NČ i stanica, posebice membrana i NČ, jer su one od iznimne važnosti za unos u stanice i nanotoksičnost.Kao nano-nosači flavonoida koristit će se dvije vrste biorazgradivih mezoporoznih NČ, silike i getita. Mezoporozne magnetske Fe3O4 NČ su odabrane kao kontrolne NČ zbog dokazanih superiornih svojstava ugradnje i otpuštanja lijekova. Kombinacijom komplementarnih eksperimentalnih tehnika, koja do sada nije u potpunosti iskorištena u području nanobiotehnologije (mikroskopija atomskih sila, spektroskopija sila, infracrvena spektroskopija s oslabljenom totalnom refleksijom, dinamičko raspršenje svijetlosti, mikrokalorimetrija), predloženi projekt će u konačnici omogućiti detaljne informacije o utjecaju veličine, oblika, naboja i hidrofobnosti NČ s ugrađenim flavonoidima na modelne membrane i neurone, posebice u uvjetima oksidativnog stresa. Također, informacije o naboju te promjeni strukturnih i nanomehaničkih svojstava modelnih odnosno neuronskih membrana će omogućiti razvoj novih, poboljšanih terapeutika za neurološke poremećaje izazvane oksidativnim stresom.]]></summary_hr><summary_en><![CDATA[Flavonoids, polyphenolic biomolecules with antioxidative activity, have recently emerged as potential novel therapeutics for neurodegenerative diseases. In addition to the fact that the mechanisms of their antioxidant effects have not yet been fully elucidated, their applicability is rendered by poor water solubility and chemical instability under physiological conditions encountered during pharmaceutical product consumption. Flavonoid incorporation in nanoparticles (NPs) as carriers has been proposed as possible solution to surpass these obstacles. Therefore, the aim of the proposed project is to overcome the problem of poor water solubility and chemical instability of flavonoids by delivering them loaded in NPs to model membranes and neurons whereby their protective effects should be enhanced. In order to confirm usefulness of this approach, interactions between NPs and cells, in particular, membrane-NP interactions, will be determined since they are of crucial importance both for cell uptake and nanotoxicity.Two kinds of biodegradable mesoporous NPs, silica and goethite, will be investigated as flavonoid nanocarriers. Fe3O4 NPs were chosen as control due to their superior drug-loading and controlled release properties. By applying combination of complementary experimental techniques not yet fully exploited in the field of nanobiotechnology (atomic force microscopy, force spectroscopy, infrared spectroscopy with attenuated total reflection, dynamic light scattering, microcalorimetry), this project will ultimately generate detailed knowledge about the effects of the size, shape, charge and hydrophobicity of NPs loaded with flavonoids on model membranes and neurons, especially under oxidative stress conditions. In addition, information about the changes in structural and nanomechanical properties of model and neuronal membranes will pave the way towards development of novel and improved therapeutic solutions for oxidative stress-associated neurological disorders.]]></summary_en></project><project>
<id>4379</id><title_hr><![CDATA[Geoprostorno praćenje zelene infrastrukture na temelju terestričkih, zračnih i satelitskih snimaka]]></title_hr><title_en><![CDATA[GEospatial Monitoring of green INfrastructure by means of terrestrial, airborne and satellite Imagery]]></title_en><user_id>3207</user_id><user_firstLast_name>Damir Medak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-5621</code><acronim><![CDATA[GEMINI]]></acronim><duration>01.03.2017 - 28.02.2021</duration><status>Završio</status><financ_value>131.528,30 eur</financ_value><scie_area_hr>Tehničke znanosti, Biotehničke znanosti, </scie_area_hr><scie_area_en>Technological sciences, Biotechnical sciences, </scie_area_en><scie_field_hr>Geodezija, Šumarstvo, </scie_field_hr><scie_field_en>Geodesy, Forestry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Geodetski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Geodesy]]></institution_en><team_members_id>7009, 7421, 13129, 6589, 20306, 3478, 20160, 20328, 3272, 20341, 25463, 26389, </team_members_id><team_members_names><![CDATA[Ivan Pilaš, Silvija  Krajter Ostoić, Robert Župan, Dubravko Gajski, Mateo Gašparović, Mario Miler, Stanislav Frangeš, Vanja Miljković, Ela Vela , Andrija Krtalić, Mihael Galinac, Petar Božičević, ]]></team_members_names><keywords_hr><![CDATA[geoinformatika, zelena infrastruktura, fotogrametrija, daljinska istraživanja, geostatistika]]></keywords_hr><keywords_en><![CDATA[geoinformatics, green infrastructure, photogrammetry, remote sensing, geostatistics]]></keywords_en><summary_hr><![CDATA[Zelena infrastruktura je mreža prirodnih i izgrađenih područja, objekata i zelenih površina u ruralnom i urbanom prostoru koja omogućuje društvu održivo zdravo okružje za svakodnevni život. Satelitska daljinska istraživanja predstavljaju ključni izvor podataka za kartiranje takvih okružja, ali nisu dovoljna za njihovo potpuno razumijevanje, jer zelena infrastruktura također sadrži i vertikalne strukture kao što su zelene terase i balkoni koje nije moguće snimiti vertikalnim satelitskim opažanjima. Nijedan pojedinačni izvor podataka nije dovoljan kako bi se kvalitetno kartiralo, pratilo, modeliralo i na kraju razumjelo i upravljalo interakcijom s takvim urbanim sustavima. Beskontaktno snimanje uz pomoć bespilotnih letjelica značajno proširuje mogućnosti prikupljanja dodatnih informacija potrebnih za praćenje zelene infrastrukture unutar urbanih područja na brz i jednostavan način. Glavni cilj ovog istraživačkog projekta je u ispitivanju i uspostavi inovativnog, više­dimenzionalnog sustava praćenja urbane zelene infrastrukture, koji integrira najnovije mogućnosti pridobivanja statičkih i dinamičkih multispektralnih informacija (satelitske snimke, zračne i terestričke snimke), naprednih prostornih analiza sa svrhom unapređenja sustava upravljanja i odlučivanja o zelenim gradskim područjima. S obzirom na trenutno stanje i značaj istraživane problematike, očekivani rezultati projekta omogućit će značajno tehnološko i metodološko unapređenje sadašnjih sustava upravljanja ZI u Hrvatskoj i Europi. Područje istraživanja obuhvaća urbano područje grada Zagreba s naglaskom na zaštićena zelena područja. Istraživanje se temelji na geoprostornim tehnologijama i metodama: daljinska istraživanja i geoinformacijski sustavi omogućit će integraciju utemeljenu na standardima Otvorenog geoprostornog konzorcija. Klasifikacija, određivanje granica objekata i ostale metode daljinskih istraživanja bit će temeljene na terestričkim, zračnim i satelitskim multispektralnim snimkama.]]></summary_hr><summary_en><![CDATA[Green infrastructure (GI) is a network of natural and semi-natural areas, features and green spaces in rural and urban areas that collectively provide society sustainable healthy living environment. Satellite remote sensing technology provides a key data source for mapping such environments, but is not sufficient for fully understanding them, because GI also comprise vertical structures like green terraces and balconies that are not detectable by perpendicular satellite imagery. No single data source is sufficient to satisfy the information needs required to map, monitor, model, and ultimately understand and manage our interaction within such urban systems. Unmanned Aerial Vehicles (UAV) based remote sensing offers great possibilities to acquire field data for monitoring of GI within the urban areas in a fast and easy way. The main objective of this research project is to establish an innovative, multidimensional system for monitoring of urban green infrastructure, which integrates the latest means of data collection (multispectral satellite imagery improved and calibrated with high resolution terrestrial and airborne multispectral sources), advanced spatial analysis with the aim to improve decision support system for better management of urban GI. Taking in the account current state of the art and the importance of research topic, the results of the project will significantly improve the technology and methodology of current management techniques of GI in Croatia as well as Europe.The proposed study area is the urban area of the city of Zagreb with focus on protected green areas inside the city. The research will be based on geospatial technologies and techniques: Remote Sensing and GIS tools and recommend a holistic integration of these technologies within the language of Open Geospatial Consortium (OGC) standards. Classification, object detection and other remote sensing methods will be based on the terrestrial, airborne and satellite multispectral imagery.]]></summary_en></project><project>
<id>4380</id><title_hr><![CDATA[Procjena svakodnevne izloženosti metalima i osobne osjetljivosti majke kao čimbenika razvojnoga podrijetla zdravlja i bolesti]]></title_hr><title_en><![CDATA[Assessment of Daily Exposure to Metals and Maternal Individual Susceptibility as Factors of Developmental Origins of Health and Disease]]></title_en><user_id>128</user_id><user_firstLast_name>Jasna Jurasović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-1998</code><acronim><![CDATA[METALORIGINS]]></acronim><duration>01.06.2017 - 31.03.2022</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Javno zdravstvo i zdravstvena zaštita, Temeljne medicinske znanosti, Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Public health and health services, Basic Medical Sciences, Clinical sciences, </scie_field_en><institution_hr><![CDATA[Institut za medicinska istraživanja i medicinu rada]]></institution_hr><institution_en><![CDATA[Institute for Medical Research and Occupational Health]]></institution_en><team_members_id>3934, 12585, 216, 3046, 341, 830, 4161, 4156, 12850, 2649, 215, 12504, 198, 4799, 640, 24445, 233, </team_members_id><team_members_names><![CDATA[Daria Pašalić, Sandra  Stasenko, Tatjana Orct, Karmen Branović Čakanić, Alica Pizent, Maja Lazarus, Irena Brčić Karačonji, Nataša Brajenović, Anja Mikolić, Blanka Tariba Lovaković, Ankica Sekovanić, Antonija Sulimanec Grgec, Zorana Kljaković-Gašpić, Jelena Kovačić, Lana Škrgatić, Iva Miškulin, Martina Piasek, ]]></team_members_names><keywords_hr><![CDATA[toksični esencijalni metal/polumetal, interakcija elemenata, pušenje cigareta, reproduktivno razdoblje žene, prenatalni razvoj, epigenetički biljezi]]></keywords_hr><keywords_en><![CDATA[toxic and essential metals/metalloids, element interaction, cigarette smoking, women’s reproductive period, prenatal development, epigenetic markers]]></keywords_en><summary_hr><![CDATA[Nepovoljni događaji tijekom prenatalnoga razvoja, majčine deficijencije nutrijenata, izloženost toksičnim metalima i pušenje cigareta, mogu izravno remetiti fetalni razvoj, ali i utjecati na postnatalno zdravlje tijekom života povećavajući rizik za brojne bolesti odrasle dobi. Projektom će se procjenjivati povoljni učinci i opasnosti u uvjetima neizbježne svakodnevne izloženosti i unosa esencijalnih i glavnih toksičnih metala/polumetala u ranjivoj skupini žena tijekom trudnoće, koji uz majčinu osobnu (negenetičku i genetičku) osjetljivost mogu utjecati na fetalnu epigenetičku regulaciju in utero i tako biti čimbenici razvojnoga podrijetla zdravlja i bolesti (koncept developmental origins of health and disease, DOAHD). Izloženosti hranom i pušenjem cigareta (samoodređenjem i pušenje određivanjem kotinina u urinu majke) te rizici za zadravlje procjenjivat će se presječnimm epidemiološkim istraživanjem metodoma humanoga biološkog monitoringa u 150 parova rodilja-dijete nakon ročnog rodničkog porođaja u rodilištu (povrh prije skupljenih sličnih podataka i bioloških uzoraka u >200 ispitanica). Biološki biljezi izloženosti/unosa bit će razine toksičnih (Cd, Pb, Hg i As) i esencijalnih (Ca, Fe, Zn, Cu i Se) metala/polumetala u majčinoj krvi/serumu i urinu, krvi/serumu pupkovine i posteljičnom tkivu. Biljezi učinaka bit će aktivnost antioksidacijskih enzima (SOD i GPx) te razine metalotioneina (MT) i posteljičnih steroidnih hormona (P4 i E2). Procijenit će se povezanosti razina metala/polumetala i MT s genskim polimorfizmima MT2A majki. Postnatalni zdravstveni rizici zbog promjena razvojnoga programiranja procijenit će se epigenetičkim markerima, metilacijom DNA i razinama ekspresije mikro RNA. Rabit će se osjetljive i sofisticirane metode i oprema za pripreme i analize uzoraka ljudskoga podrijetla. Jedinstveni doprinos u biomedicinskim istraživanjima bit će dobivanje inovativnih podataka u toksikogenomici – okolišnoj epigenetici metala, prvi te vrste u Hrvatskoj.]]></summary_hr><summary_en><![CDATA[Prenatal insults, such as maternal nutrient deficiencies, toxic metals’ exposure and cigarette smoking may disrupt fetal growth not only directly, but may also have impact on postnatal health across the life course increasing a risk for various diseases in adulthood. The project will assess health benefits and risks of unavoidable, daily environmental exposure and intake of nutritionally essential and main toxic metals/metalloids in a vulnerable population group of women during child-bearing period that, along with maternal individual (non-genetic and genetic) susceptibility, may alter intrauterine fetal epigenetic regulation and thus may be factors of developmental origins of health and disease (paradigm DOAHD). The exposures via food and tobacco smoking (based on self-reporting and smoking quantified by maternal urine cotinine) and health risks will be assessed in a cross-sectional epidemiological study using methods of human biological monitoring in 150 postpartum women-infant pairs after term vaginal deliveries in a maternity hospital (in addition to previously collected data and similar samples in >200 participants). Biomarkers of exposure/intake will be toxic (Cd, Pb, Hg, As) and essential (Ca, Fe, Zn, Cu, Se) metal/metalloid levels in maternal blood/serum and urine, umbilical cord blood/serum and placental tissue. Biomarkers of effects will be antioxidant enzymes (SOD, GPx), metallothionein (MT), and placental steroid hormones (P4, E2). Associations of maternal metal/metalloid and MT levels with MT2A genetic polymorphisms will be assessed. Potential postnatal health risks due to developmental programming changes will be evaluated by epigenetic markers, DNA methylation and microRNA expression levels. Sensitive and sophisticated methods and equipment for human sample preparations and analyses will be used. Unique contribution in biomedical research will be providing novel data in toxicogenomics–environmental epigenetics of metals, first of that kind in Croatia.]]></summary_en></project><project>
<id>4387</id><title_hr><![CDATA[Energetski neovisna Hrvatska bazirana na visokom udjelu obnovljivih izvora energije te različitih tehnologija brzog odziva]]></title_hr><title_en><![CDATA[Energy independent Croatia based on high penetration of Renewable Energy Sources and demand response technologies]]></title_en><user_id>13012</user_id><user_firstLast_name>Neven Duić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>PKP</proposal_type><proposal_call>2016-06</proposal_call><code>PKP-2016-06-3300</code><acronim><![CDATA[RESFlex]]></acronim><duration>01.04.2017 - 31.03.2019</duration><status>Završio</status><financ_value>178.392,73 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, Elektrotehnika, Računarstvo, Tehnologija prometa i transport, </scie_field_hr><scie_field_en>Mechnical engineering, Electrical engineering, Computer sciences, Transport technology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>13036, 13333, 6990, 20485, 13053, 20505, 20525, 19762, 22649, 12978, 22565, 25095, </team_members_id><team_members_names><![CDATA[Tomislav Pukšec, Goran Krajačić, Zeljko Tomšić, Henrik Lund, Tomislav Novosel, Natasa Markovska, Michael  Narodoslawsky, Marko Ban, Borna Doračić, Boris Ćosić, Nikola Matak, Hrvoje  Dorotić, ]]></team_members_names><keywords_hr><![CDATA[Niskougljični razvoj, Dugoročno energetsko planiranje, integracija OiE, tehnologije brzog odziva, elektrifikacija transportnog sektora, satni modul po]]></keywords_hr><keywords_en><![CDATA[Low carbon development, long term energy planning, RES integration, demand response technologies, electrification of the transport sector, hourly dema]]></keywords_en><summary_hr><![CDATA[Cjelovita energetska politika EU sastavljena je od niza pojedinačnih strategija integriranih u cjeloviti energetsko klimatski paket. Kao rezultat te cjelovite politike nameće se postupna tranzicija ka niskougljičnom razvoju i društvu. U energetskom smislu, ključne će biti strategije integracije obnovljivih izvora energije (OiE) na EU razini te dugoročna kroz-sektorska politika energetske učinkovitosti.  Republika Hrvatska, kao punopravna članica EU, dužna je osigurati tehnički i cjenovno optimalnu tranziciju, imajući u vidu maksimalnu korist za čitavo društvo; energetsku, gospodarsku te ekološku. Niz tehnologija koje iskorištavaju OiE su danas tehnički i ekonomski u potpunosti konkurentne te smo došli u situaciju u kojoj su potrebne nove sheme integracije; kako tehničke tako i financijske. S financijske strane je potrebna razrada novih mehanizama integracije obnovljivih tehnologija, temeljenih na mrežnom paritetu, te satnim tržištima energije. S tehničke strane potrebna je razrada inovativnih mehanizama fleksibilizacije, prije svega elektroenergetskog sustava, gdje dolazi do promjene paradigme u kojoj prelazimo sa sustava u kojem proizvodnja prati potrošnju na sustav u kojem potrošnja prati varijabilnu proizvodnju. Kao temelji ove nove paradigme javljaju se tehnologije koje omogućuju kroz-sektorsku integraciju OiE, kao što su power2heat/cool tehnologije (spremanje viškova električne energije kroz toplinske spremnike i centralizirane toplinske/rashladne sustave temeljene na inovativnim tržišnim mehanizmima), različiti oblici skladištenja energije, elektrifikacija transporta, fleksibilizacija potrošnje i sl. Predmet ovog istraživanja je integracija prethodno navedenih problema kroz napredan open access modelski okvir koji će zaživjeti kroz interaktivnu Internet platformu. Koncept pametnog energetskog sustava biti će razvijan pristupom odozdo prema gore, kako bi se omogućila modularnost sustava, uključujući lokalni/regionalni/nacionalni aspekt modeliranja]]></summary_hr><summary_en><![CDATA[EU energy policy as a whole is made out of a number of different strategies that are integrated into a climate & energy package. This policy results in gradual transition towards low-carbon development and society. In terms of energy, strategies for implementation and integration of renewable energy sources, on EU level will be the key, as well as long-term cross-sector energy efficiency policy. Croatia, as a full member of EU, is obliged to ensure technically and economically optimal transition in terms of energy, economy and ecology, to provide maximal benefit for the society as a whole. A number of different technologies that are utilising renewable energy sources are now completely technically and economically competitive. Because of that, new integration schemes are necessary, both from technical and financial perspective. From financial perspective, new mechanisms for integration of renewable technologies need to be developed, based on grid parity and hourly energy markets. From technical perspective, innovative mechanisms for flexibilisation of power system need to be developed. This leads to a transition from current system, where supply follows demand, to a new system, where demand follows supply. The basis for this new paradigm are new technologies that enable cross-sector integration of intermittent energy sources, like power2heat/power2cool technologies (storing excess electricity by the means of heat storage and district heating and cooling systems, which are based on innovative market mechanisms), different energy storage technologies, transport electrification, flexibilisation of consumption, etc. The subject of this research is integration of abovementioned problems through an advanced open access model framework, which will function as an interactive online internet platform. Smart energy system concept will be developed with bottom up approach, since this enables modularity of the system, including local/regional/national modelling aspect. ]]></summary_en></project><project>
<id>4388</id><title_hr><![CDATA[Glikozilacija alfa kiselog glikoproteina - put prema personaliziranoj terapiji]]></title_hr><title_en><![CDATA[Glycosylation of alpha-1- acid glycoprotein - route to personally oriented medicine]]></title_en><user_id>12360</user_id><user_firstLast_name>Mario Gabričević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-3672</code><acronim><![CDATA[GlycoDrugs]]></acronim><duration>20.03.2017 - 19.02.2022</duration><status>Prekinut</status><financ_value>129.139,29 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Farmacija, Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Pharmaceutical sciences, Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Farmaceutsko-biokemijski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Pharmacy and Biochemistry]]></institution_en><team_members_id>4009, 1075, 13603, 25302, 26516, </team_members_id><team_members_names><![CDATA[Tin Weitner, Ognjen Čulić, Erim Bešić, Robert Kerep, Tino Šeba, ]]></team_members_names><keywords_hr><![CDATA[alfa kiseli glikoprotein, glikozilacija, konstanta vezanja lijeka, personalna terapija, lijekovi ]]></keywords_hr><keywords_en><![CDATA[alpha acid glycoprotein, glycosylation, drug binding constant, personally oriented therapy, drugs ]]></keywords_en><summary_hr><![CDATA[Nakon što se lijek aplicira u krv, on se najčešće u određenoj mjeri vezuje na proteine plazme. Važnost ovakvog vezanja je dobro opisana u literaturi, a udio vezanja pri ravnotežnim uvjetima određuje koncentraciju slobodnog lijeka. Slobodni udio lijeka je najčešće onaj koji je raspoloživ za aktivnost ili difuziju u okolna tkiva te se stoga samo nevezana frakcija lijeka smatra aktivnim oblikom, u skladu s “principom slobodnog lijeka”. Kao posljedica visoke koncentracije, proteini plazme kontroliraju koncentraciju slobodnog lijeka u plazmi, kao i u biološkim odjeljcima koji su s njom u ravnoteži, utječući na taj način na djelotvornost in vivo. U kliničkom smislu ovaj kapacitet treba se uzeti u obzir kad se određuje doza lijeka ili procjenjuje moguća toksičnost primijenjenog lijeka, što je obično dodatno usloženo uslijed promijena u kapacitetu proteina za vezanje lijeka kod određenih pacijenata. Izrazito glikozilirani alfa kiseli glikoprotein je jedan od dva proteina koji vežu veliki broj različitih lijekova i općenito utječu na djelotvornost lijekova. Postoje tri genetičke varijante i to F1, S i A. Vezanje lijekova za AGP može biti promijenjeno i u brojnim patološkim i fiziološkim stanjima kao rezultat promjene u glikozilacijskom uzorku. Ukupno gledano, tri faktora utječu na vezanje lijekova za AGP: Koncentracija AGP-a, omjer različitih genetičkih varijanti i promjene u glikozilacijskom uzorku. Ciljevi projekta su: 1. Kako različite genetičke varijante AGP-a utječu na ukupno vezanje lijekova? 2. Kakav je utjecaj promijenjenog glikozilacijskog uzorka na vezanje lijekova 3.  Predviđenje slobodnog udijela lijeka ovisno o navedena tri faktora. Koristit će se fizikalne metode kao fluorescencijska spektroskopija, ravnotežna dijaliza i masena spektroskopija kako bi se odredio utjecaj glikozilacijskih promjena AGP-a na vezanje lijekova i posljedično predvidio utjecaj te promjene na terapiju.]]></summary_hr><summary_en><![CDATA[After the administration of the drug to the blood stream, it often binds to a certain extent to plasma proteins. The importance of such plasma protein binding is a well recognized phenomenon and the extent of this association at equilibrium determines the concentration of unbound drug. Free fraction of the drug is most commonly the only one available for active uptake or diffusion into the surrounding tissue according to the “free drug principle”. Due to their high concentration, the plasma proteins control the free drug concentration in plasma thus influencing the drug potency in vivo. Clinically, this effect should be considered when adjusting the dosage of a drug, as well as in assessing the toxicity of the administered drug which is often complicated by changes in patient’s protein-binding capacity. Heavily glycosylated alpha-1-acid glycoprotein (AGP) is one of two proteins present in sufficient quantity to bind a broad variety of drugs and generally has a significant effect on drug action. Adding to complexity, human AGP exists as a heterogeneous population of three genetic variants namely F1, S and A. Importantly, drug binding to the AGP may be altered in numerous pathological and physiological states as a result of changes in glycosylation pattern. Overall, there are three major factors influencing binding of drugs to AGP: Concentration of AGP, ratio of different genetic forms and changes in glycosylation. Goals of this project are: 1. How different genetic forms of native AGP influence the overall drug binding? 2. What is the influence of changed glycosylation patterns of AGP on drug binding? 3. “Free drug” prediction dependent on mentioned three factors. We will use physical methods like fluorescence spectroscopy, equilibrium dialysis and MS to evaluate influence of AGP glycosylation change on drug binding and subsequently predict influence on drug therapy.]]></summary_en></project><project>
<id>4406</id><title_hr><![CDATA[Aminoacil-tRNA-sintetaze kao čuvari standardnog genetičkog koda]]></title_hr><title_en><![CDATA[Aminoacyl-tRNA synthetases as gatekeepers of the standard genetic code]]></title_en><user_id>7711</user_id><user_firstLast_name>Ita Gruić Sovulj</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-6272</code><acronim><![CDATA[AARSCODE]]></acronim><duration>01.03.2017 - 31.08.2021</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, Biologija, </scie_field_hr><scie_field_en>Chemistry, Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>19864, 20026, 19876, 19945, 20081, 20056, 20017, 24303, 24302, 27538, </team_members_id><team_members_names><![CDATA[Marko Močibob, Morana Dulić, Mario Kekez, Maja Barači, Jasmina Rokov Plavec, Nediljko Budiša, Gregor Anderluh, Marija Viher, Igor Živković, Valentina Ević, ]]></team_members_names><keywords_hr><![CDATA[aminoacil-tRNA-sintetaze, biosinteza proteina, kontrolni mehanizmi u translaciji, norvalin, sintetske aminokiseline, editing]]></keywords_hr><keywords_en><![CDATA[aminoacyl-tRNA synthetases, protein biosynthesis, translational quality control, norvaline, synthetic amino acids, editing]]></keywords_en><summary_hr><![CDATA[Genetički kod definira zakonitosti koje omogućavaju prevođenje genetičke informacije u funkcionalne molekule proteina. Suodnos kodona i aminokiseline ostvaruje se pomoću aminoacil-tRNA-sintetaza (aaRS), enzima koji sparuju aminokiselinu s pripadnom molekulom tRNA. Visok stupanj točnosti u translaciji osigurava se dijelom kroz korektivne mehanizme enzima aaRS. Učestalost mistranslacije predstavlja važno pitanje u temeljnim istraživanjima i njihovoj primjeni u medicini i biotehnologiji. Korektivni mehanizmi također djeluju kao čuvari standardnog genetičkog koda i sprječavaju ugradnju prirodnih aminokiselina koje nisu definirane genetičkim kodom. Ti mehanizmi, s druge strane, mogu otežati ugradnju sintetskih aminokiselina u dizajnerske proteine.U sklopu projekta predlaže se istraživanje sintetskih i korektivnih mehanizama enzima koji omogućuju ugradnju leucina, valina i izoleucina u proteine. Usporedit ćemo katalitičke principe i specifičnost sintetskog i korektivnog mjesta tih enzima prema proteinogenim aminokiselinama i onima koje nisu kodirane genetičkim kodom. Također, istražit ćemo toksičnost mistranslacije i stanični odgovor na izazvani stres. Cilj je razumjeti principe koji definiraju odabir standardne aminokiselinske abecede te kako narušavanje genetičkog koda utječe na staničnu fiziologiju. Navedene spoznaje olakšat će usmjerenu ugradnju fluoriranih aminokiselina u dizajnerske proteine. Konačno, testirat ćemo postojanje sprege između točnosti translacije i adaptacije na stres izazvan okolišnim uvjetima.Ovo istraživanje, kroz redizajniranje suodnosa kodona i aminokiseline, nalazi se na granici biokemije i kemijske biologije. Atraktivnost i izvedivost predloženog istraživanja uočljiva je kroz suradnje naše grupe, značajno prepoznate u polju biosinteze proteina, s istaknutim internacionalnim (Prof. Budiša, TU Berlin, Prof. Anderluh, NIC, Ljubljana, Prof. Maček, Proteome Center Tübingen) i domaćim (Dr. Vianello, IRB, Zagreb) partnerima. ]]></summary_hr><summary_en><![CDATA[The genetic code provides the basis for translation of genetic information into functional proteins. Codon assignments are established by aminoacyl-tRNA synthetases (aaRS), which couple amino acids to their cognate tRNAs. Mistakes in translation are generally kept low, in part by inherent aaRS hydrolytic editing. The extent to which mistranslation occurs presents a fundamental question in basic research with impact on medicine and biotechnology. AaRS quality control mechanisms also act as gatekeepers of the standard genetic code and prevent infiltration of natural but non-coded amino acids. Consequently, they present an obstacle for synthetic amino acid translation in rational protein design.Here we propose to investigate the synthetic and editing mechanisms of three aaRSs responsible for translation of amino acids that build the protein core: leucine, valine and isoleucine. We will compare the catalytic principles and gained specificity of the enzymes’ synthetic and editing sites against proteinogenic and non-coded amino acids. The cellular toxicity and stress responses of induced non-canonical mistranslation will be addressed. The goal is to improve our understanding of the basis for selection of the natural amino acid alphabet, and how violation of the coding principles influences cell physiology. Mechanistic insight will extend our ability to apply fluorinated amino acids in protein rational design. A possible link between altered translational fidelity and adaptation to environmental stress will be sought. This research couples biochemistry and chemical biology through the interest in reassignment of the genetic code. The assembled expertise through the international (Prof. Budiša, TU Berlin, Prof. Anderluh, NIC, Ljubljana, and Prof. Maček, Proteome Center Tübingen) and national (Dr. Vianello, RBI, Zagreb) collaborators will strongly enhance the capacity of our group, which is well-recognized in the field of protein translation, to conduct this research.]]></summary_en></project><project>
<id>4414</id><title_hr><![CDATA[Kooperativna robotika u nadzoru i istraživanju mora]]></title_hr><title_en><![CDATA[Cooperative robotics in marine monitoring and exploration]]></title_en><user_id>5962</user_id><user_firstLast_name>Nikola Mišković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-2082</code><acronim><![CDATA[CroMarX]]></acronim><duration>01.04.2017 - 31.12.2021</duration><status>Završio</status><financ_value>132.258,28 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, Temeljne tehničke znanosti, </scie_field_hr><scie_field_en>Electrical engineering, Basic engineering sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>19968, 18903, 6426, 19973, 19989, 20001, 19979, 17737, 21329, </team_members_id><team_members_names><![CDATA[Anja Babić, Zoran Vukić, Antonio Vasilijević, Ivan Lončar, Zdravko Eškinja, Đula Nađ Nađ, Marin Stipanov, Filip Mandić, Nadir Kapetanović, ]]></team_members_names><keywords_hr><![CDATA[robotika, kooperativna robotika, pomorska robotika, autonomna površinska plovila, autonomna ronilica, višerobotski sustavi]]></keywords_hr><keywords_en><![CDATA[robotics, cooperative robotics, marine robotics, autonomous surface marine vehicles, autonomous underwater vehicle, multi-robot systems]]></keywords_en><summary_hr><![CDATA[Bespilotna plovila (površinska i podvodna) se uspješno koriste za nadzor i istraživanje mora. Ona igraju veliku ulogu u mnogim područjima primjena kao što su morska biologija, morska ekologija, podvodna arheologija, akvakultura, pomorska sigurnost, offshore industrija. Sve pomorske zemlje, kao i Hrvatska koja ima jurisdikciju nad skoro polovicom Jadranskog mora, imaju obavezu nadgledati, istraživati i štititi svoja morska dobra.CroMarX projekt unosi novu dimenziju u nadzor i istraživanje mora uvođenjem kooperativnih plovila koja povećavaju operativnu učinkovitost. Glavni cilj CroMarX projekta je istražiti i razviti kooperativne upravljačke algoritme  u području pomorske robotike, uzimajući u obzir bespilotna površinska plovila (USV, engl. Unmanned Surface marine Vehicles) i bespilotne ronilice (UUV, engl. Unmanned Underwater Vehicles) u svrhu nadzora i istraživanja mora. Prvo, razvit ćemo kooperativne strategije za upravljanje flotom USV-ova kako bi se povećale sposobnosti distribuiranog nadzora mora. Drugo, razvit ćemo upravljačke algoritme koji omogućuju kooperaciju između USV-a i UUV-a, što će značajno povećati istraživačke sposobnosti UUV-ova kroz unaprjeđenje navigacijskih mogućnosti. Treće, razvit ćemo sustav za upravljanje misijama koji će osigurati pregled stanja plovila i imati ulogu korisniku prihvatljivog centra za upravljanje i zadavanje misija pojedinačnom plovilu kao i floti plovila. Na kraju, razvijeni algoritmi će biti eksperimentalno potvrđeni u sklopu tri definirana scenarija: 1) kooperativno upravljanje flotom USV-ova, 2) upravljanje flotom USV-ova koje se adaptira utjecajima iz okoliša, i 3) kooperativno upravljanje između USV-a i UUV-a.]]></summary_hr><summary_en><![CDATA[Unmanned marine vehicles (surface and underwater) are successfully exploited for monitoring and exploring the marine environment. They play a large role in many application fields such as marine biology, marine ecology, underwater archaeology, aquaculture, marine security, offshore industry. All maritime countries, as well as Croatia with jurisdiction over almost half of the Adriatic Sea, have the obligation to monitor, explore and protect their marine environment.CroMarX project brings a new dimension to marine monitoring and exploration by introducing cooperative marine vehicles that increase operational efficiency. The main objective of the CroMarX project is to investigate and develop cooperative control algorithms in the area of marine robotics, taking into account both unmanned surface marine vehicles (USVs) and an unmanned underwater vehicle (UUV) for the purpose of marine monitoring and exploration. Firstly, we will develop cooperative control strategies for operating a fleet of USVs in order to increase capabilities of distributed marine monitoring operations. Secondly, we will develop control algorithms that allow cooperation between a USV and a UUV, which will significantly enhance exploratory abilities of UUVs by increasing their navigational capabilities. Thirdly, we will develop a mission controller that will ensure situational awareness and act as a user-friendly command and control centre for commanding missions to individual vehicles as well as fleets of vehicles. Finally, the developed algorithms will be experimentally validated within three defined scenarios: 1) cooperative control of a fleet of USVs, 2) environmentally adaptive control of a fleet of USVs, and 3) cooperative control between a USV and a UUV. ]]></summary_en></project><project>
<id>4425</id><title_hr><![CDATA[ET TIBI DABO: naručitelji i donatori umjetnina u Istri, Hrvatskom primorju i sjevernoj Dalmaciji od 1300. do 1800. godine]]></title_hr><title_en><![CDATA[ET TIBI DABO: Commissions and Donors in Istria, Croatian Littoral and North Dalmatia from 1300 to 1800]]></title_en><user_id>269</user_id><user_firstLast_name>Nina Kudiš</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-1265</code><acronim><![CDATA[donart]]></acronim><duration>20.03.2017 - 19.09.2021</duration><status>Završio</status><financ_value>73.304,83 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Povijest umjetnosti, Povijest, Arheologija, </scie_field_hr><scie_field_en>Art history, History, Archeology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Filozofski fakultet u Rijeci]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>839, 700, 845, 847, 1088, 2946, 1009, 20021, 20064, 20071, 20138, 3253, 25243, 27385, </team_members_id><team_members_names><![CDATA[Marijan Bradanović, Laris Borić, Damir Tulić, Mateja Jerman, Danijel Ciković, Ivan Braut, Iva Jazbec Tomaić, Ana Šitina, Petar Puhmajer, Krasanka Majer Jurišić, Josip Višnjić, Željko Bistrović, Mario Pintarić, Marin Bolić, ]]></team_members_names><keywords_hr><![CDATA[donatori, naručitelji, društv. elite, Istra, Hr. primorje, sjev. Dalmacija, arhitektura, skulptura, slikarstvo, primijenjena umjetnost, 1300. – 1800. ]]></keywords_hr><keywords_en><![CDATA[donors, commissions, social elites, Istria, Croatian Littoral, North Dalmatia, architecture, sculpture, painting, applied arts, 1300 - 1800]]></keywords_en><summary_hr><![CDATA[Cilj projekta je istražiti utjecaj društvenih elita i pojedinaca na širenje umjetničkih oblika, stilova i rješenja. Taj su proces na području Hrvatske što je u žarištu ovog istraživanja, dijelom kreirali i najvažniji predstavnici europskih dvorova, poput habsburških careva, bavarskih vojvoda, venecijanskih duždeva, apostolskih nuncija i kardinala. Uvid u razloge i odlike njihovih narudžbi omogućit će bolje razumijevanje položaja i htijenja lokalnih donatora u europskom kontekstu. Primjenom metode istraživanja pojedinačnih slučajeva, pokušat će se doći do zaključaka, primjenjivih ne samo na područje jadranske Hrvatske, već i na teritorij Mletačke republike, Apeninskog poluotoka i Srednje Europe. U radu na projektu će uz voditeljicu sudjelovati još 12 istraživača, od kojih je 6 iskusnih znanstvenika s brojnim radovima objavljenim u Hrvatskoj i inozemstvu, a čak 6 mlađih istraživača su studenti doktorskih studija. Glavnina rada na projektu sastojat će se od istraživanja na terenu te usavršavanja u hrvatskim i inozemnim bibliotekama i arhivima. Rezultati istraživanja na projektu, čiji se dodir s interdisciplinarnošću ogleda u povezivanju povijesno-umjetničkog i historiografskog istraživanja, kao i istraživanja socijalnih fenomena, bit će od koristi istraživanjima u heraldici, genealogiji, sfragistici, etnologiji, povijesti književnosti, glazbe i mode te povijesti društva i kulture. U okviru projekta organizirat će se dvije znanstvene radionice i dva međunarodna znan. skupa na kojima će uz istraživače na projektu sudjelovati i drugi znanstvenici iz Hrvatske i inozemstva. Sva četiri skupa rezultirat će zbornicima radova opremljenima znanstvenom aparaturom te objavljenima na internetskoj stranici projekta. Jedan od važnih ciljeva projekta je i diseminacija rezultata istraživanja koja će se provoditi kroz javna predavanja istraživača, prisustvo u medijima, ali naročito kroz kraće diseminacijske tekstove koje će istraživači sustavno objavljivati na blog stranici projekta. ]]></summary_hr><summary_en><![CDATA[The project intends to investigate the influence of the social elites and individuals on the propagation of artistic forms, styles and solutions. In the Croatian territory that will be in the focus of this project, such a process was significantly shaped by the most important representatives of the European courts, such as Habsburg emperors, Bavarian Dukes, Venetian doges, Apostolic Nuncios and Cardinals. A better insight into reasons and characteristics of their commissions will generate a better understanding of the situation and aspirations of the local donors in the European context. By applying the “case study” methodology, we will try to reach conclusions, valid not only for the complete Croatian littoral, but also for the territory of the Venetian Republic, the Apennine Peninsula and Central Europe. Apart from the principal investigator, 12 researchers will take part in the project, half of which are experienced scholars with numerous papers published in Croatia and abroad and half of them are concluding their PhD studies. The project will mainly consist in field research and training and research in the Croatian and international libraries and archives. The results of the research, that interconnects art history and historiography, as well as the research of social phenomena, should also prove valuable for the research in heraldry, genealogy, sphragistics, ethnology, history of literature, music, fashion, as well as the cultural history. The project will also comprise two workshops for the participants and two international conferences, all resulting in proceedings that will be published online. One of the most important goals of the project is the dissemination of the research results through its web page and blog (numerous shorter articles by all the researchers), public lectures and the media.]]></summary_en></project><project>
<id>4428</id><title_hr><![CDATA[Razvoj integriranog mikrosustava za biokatalitičku proizvodnju biodizela]]></title_hr><title_en><![CDATA[Development of integrated micro-system based biocatalytic process for biodiesel production]]></title_en><user_id>7049</user_id><user_firstLast_name>Bruno Zelić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-7993</code><acronim><![CDATA[DeMSy(BioPro)2]]></acronim><duration>01.05.2017 - 30.04.2021</duration><status>Završio</status><financ_value>99.628,38 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Kemijsko inženjerstvo, Temeljne tehničke znanosti, </scie_field_hr><scie_field_en>Chemical engineering, Basic engineering sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet kemijskog inženjerstva i tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Chemical Engineering and Technology]]></institution_en><team_members_id>428, 6308, 4070, 309, 4717, 4306, 6012, 9886, 25366, 25444, 25659, </team_members_id><team_members_names><![CDATA[Anita Šalić, Ana Jurinjak Tušek, Ana  Bucić-Kojić, Marina Tišma, Mirela Planinić, Sandra Budžaki, Davor Valinger, Dinko Sinčić, Martin Gojun, Marta Ostojčić, Darijo Šibalić, ]]></team_members_names><keywords_hr><![CDATA[biodizel, enzim lipaza, pročišćavanje, mikroreaktor, integrirani proces]]></keywords_hr><keywords_en><![CDATA[biodiesel, lipase, purification, microreactor, integrated process]]></keywords_en><summary_hr><![CDATA[U današnje vrijeme kada se raspoloživost i dostupnost fosilnih goriva značajno smanjuje, potreba za proizvodnjom biogoriva iz različitih obnovljivih izvora je sve izraženija. Biorazgradivost, netoksičnost i mala emisija štetnih tvari samo su neka od svojstava koja čine biodizel ekološki prihvatljivijim gorivom. Cilj ovog projekta je razviti integrirani mikrosustav za biokatalitičku proizvodnju biodizela. U tu svrhu će se proizvesti biokatalizator, enzim lipaza podrijetlom iz gljive Thermomyces lanuginosus fermentacijom na čvrstom otpadu prehrambene industrije kao supstrat, sintetizirati biodizel transesterifikacijom u kotlastom bioreaktoru i različitim mikroreaktoriskim sustavima korištenjem komercijalno dostupne i lipaze proizvedene fermentacijom na čvrstim nosačima pomoću gljive T. lanuginosus, provesti separaciju glicerola u prvoj fazi i pročišćavanje dobivenog biodizela u drugoj fazi primjenom membranske ultrafiltracije na modulima sa šupljim vlaknima kako bi proizvedeni biodizel kvantitativno i kvalitativno zadovoljio propisane norme. Kao supstrat u procesu transeterifikacije koristit će se svježe i otpadno jestivo ulje, a rezultati pokusa provedenih u različitim reaktorskim konfiguracijama će se usporediti kako bi se izabrao najpogodniji reakcijski sustav. Po prvi puta razvit će se integrirani mikroreaktorski sustav koji će na jednom čipu omogućiti kontinuiranu proizvodnju biodizela dok će se na drugom čipu odvijati kontinuirana separacija i pročišćavanje biodizela korištenjem filtera integriranih u sustav. Osim provedbe pokusa posebna pozornost će se posvetiti i razvoju matematičkog modela procesa proizvodnje biodizela u mikroreaktoru. Razvit će se 2D i 3D matematički model procesa, a rezultati simulacije matematičkog modela procesa koristit će se u svrhu boljeg razumijevanja strujanja reakcijske smjese u mikrokanalu, optimizacije procesa i uvećanja procesa.]]></summary_hr><summary_en><![CDATA[Nowadays as the availability and accessibility of fossil fuels is significantly declining, the need for the production of biofuels from various renewable sources is becoming increasingly interesting. Biodegradability, non-toxicity and low pollution emissions are merely some properties making biodiesel a more environmentally friendly fuel. The aim of this project is to develop an integrated microsystem for the biocatalytic production of biodiesel. For this purpose: (i) an enzyme lipase from the fungus Thermomyces lanuginosus will be produced on solid waste from food industry, (ii) biodiesel will be produced using transesterification reaction in a stirred-tank bioreactor and different microrector systems utilising a commercially available lipase and a lipase produced by solid-state fermentation using the fungus T. lanuginosus, (iii) separation of glycerol will be carried out in the first phase and purification of the obtained biodiesel in the second phase applying  the membrane ultrafiltration modules with hollow fibres to produce biodiesel that quantitatively and qualitatively fulfils the prescribed standards. Fresh and waste cooking oil will be used as a substrate in the transesterification process. The results of the experiments conducted in different reactor configurations will be compared in order to select the most appropriate reaction system. For the first time, an integrated microreactor system will be developed. The continuous production of biodiesel will take place in a single chip, while another chip will be used for continuous separation and purification of biodiesel using a filter integrated into the system. Special attention will be paid to the development of mathematical models for biodiesel production in a microreactor. 2D and 3D mathematical models will be developed for the processes and the results of mathematical model simulations will be used to better understand the flow of the reaction mixture, process optimization and process scale up.]]></summary_en></project><project>
<id>4430</id><title_hr><![CDATA[Sintetička magnetska polja uz međudjelovanja i anyoni]]></title_hr><title_en><![CDATA[Synthetic magnetic fields with interactions and anyons]]></title_en><user_id>5776</user_id><user_firstLast_name>Hrvoje Buljan</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-5885</code><acronim><![CDATA[SynthMagIA]]></acronim><duration>15.03.2017 - 14.03.2021</duration><status>Završio</status><financ_value>110.522,66 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>19416, 19411, 4493, 856026, 4045, </team_members_id><team_members_names><![CDATA[Dario Jukić, Tena Dubcek Dubcek, Karlo Lelas, Marija  Todorić, Bruno Klajn, ]]></team_members_names><keywords_hr><![CDATA[međudjelujući bozonski plin, sinetetičko magnetsko polje, anyoni, nelinearnost, fotoničke rešetke]]></keywords_hr><keywords_en><![CDATA[interacting Bose gases, synthetic magnetic fields, anyons, nonlinearity, photonic lattices]]></keywords_en><summary_hr><![CDATA[U ovom projektu istražujemo međudjelujuće ultrahladne atomske plinove u sintetičkim magnetskim (baždarnim) poljima (SMGF od eng. Synthetic Magnetic/Gauge Field), moguće eksperimentalne realizacije anyona (čestica s necjelobrojnom statistikom koja interpolira između statistike za bozone i fermione), te analogne fotoničke sustave. Naš tim ima višegodišnje iskustvo istraživanja međudjelujućih ultrahladnih atomskih plinova i fotoničkih sustava, što se izvrsno uklapa u tematiku projekta. Čuveno necjelobrojno kvantno Hallovo (FQH) stanje pojavljuje se u sustavu međudjelujućih nabijenih čestica u jakom magnetskom polju, zatočenim u dvije dimenzije (2D). Anyoni su dosad eksperimentalno realizirani kao kvazičestice višečestičnih pobuđenja samo u tom sustavu. Bogatstvo FQH stanja motivira potragu za novim (topološkim) stanjima tvari u međudjelujućim bozonskim sustavima. Ultrahladni atomski plinovi idealan su poligon za kontroliranu pripremu, manipulaciju i detekciju kvantnih višečestičnih stanja. Kako bi ostvarili topološka stanja (analogna FQH stanju) u ultrahladnim plinovima, potrebno je stvoriti SMGF u kojem će se (neutralni) atomi ponašati kao elektroni u magnetskom polju. Većina radova o SMGF dosad bila je fokusirana na jednočestične efekte, što nas motivira za ovo istraživanje. Znanstveni dio projekta organiziran je u tri radna paketa (WP od eng. Work Package). U WP1 istražujemo SMGF u međudjelujućim bozonskim sustavima, za sve raspone međudjelovanja i dimenzionalnosti (1D-3D). Ciljevi su (i) otkrivanje i istraživanje novih topoloških faza i stanja, te (ii) istraživanje granica samih metoda, sugerirajući poboljšanja i nove sheme. U WP2, anyoni u ultrahladnim atomskim plinovima, ciljevi su (i) istražiti i predložiti moguće eksperimentalne realizacije anyona koristeći ultrahladne plinove, te (ii) predložiti i proučiti potpise anyona u tim sustavima (npr. simulirajući time-of-flight eksperimente u 2D). U WP3 ćemo povezati naš rad sa SMGF u fotoničkim sustavima. ]]></summary_hr><summary_en><![CDATA[In this project we explore interacting ultracold atomic gases in synthetic magnetic (gauge) fields (SMGF), explore potential experimental realizations and signatures of anyons (particles with fractional statistics interpolating between bosons and fermions), and analogous photonic systems. Our team has expertise and experience of research in interacting ultracold atomic gases as well as in optics and photonics; thus, the design of the project is perfectly suited for our team. The famous fractional quantum Hall (FQH) state emerges in a system of interacting charged particles in a strong magnetic field, confined in two-dimensions (2D). The richness of FQH state motivates the quest for novel topological states of matter in interacting bosonic systems. Ultracold atomic gases are ideal playground for a controlled preparation, manipulation, and detection of quantum many-body states. To achieve topological states (such as the FQH state) in ultracold atomic gases, one must create a SMGF wherein (neutral) atoms behave as electrons in a magnetic field. Most of the work on SMGF up-to-date was focused on single particle effects, which provides great motivation for this project. The scientific effort is systematically organized in three workpackages (WP). In WP1, synthetic gauge/magnetic fields in interacting bosonic systems, all interaction ranges and dimensionalities (1D-3D) are explored. The objectives are to (i) discovering and exploring novel topological phases and states and (ii) to explore the boundaries and limitations of methods, suggesting improvements and novel schemes. In WP2, anyons in ultracold atomic gases, the objectives are (i) to explore and propose potential experimental realization of anyons using ultracold gases, and (ii) to propose and investigate the signatures of anions in these systems (e.g., by simulating time-of-flight experiments in 2D). In WP3, we connect our work to synthetic magnetic fields in photonics.]]></summary_en></project><project>
<id>4437</id><title_hr><![CDATA[Politika vremena u post-jugoslavenskoj prozi: Zamišljanje temporalnosti književnih kultura transnacionalnosti ]]></title_hr><title_en><![CDATA[The Politics of Time in the post-Yugoslav Prose: Imagining Temporalities of Literary Cultures of Transnationality]]></title_en><user_id>6591</user_id><user_firstLast_name>Aleksandar Mijatović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-9548</code><acronim><![CDATA[POLITI]]></acronim><duration>06.03.2017 - 05.05.2019</duration><status>Završio</status><financ_value>38.821,42 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filologija, Filozofija, Povijest, </scie_field_hr><scie_field_en>Philology, Philosophy, History, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Filozofski fakultet u Rijeci]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>3737, 19173, 1368, 19690, 12357, 1335, </team_members_id><team_members_names><![CDATA[Danijela Marot Kiš, Dejan Durić, Saša Stanić, Eva Simčić, Miranda Levanat-Peričić, Marina Biti, ]]></team_members_names><keywords_hr><![CDATA[pripovijedanje, vrijeme, subjekt, transnacionalnost, tekst, kultura, pamćenje]]></keywords_hr><keywords_en><![CDATA[narration, time, subject, transnationality, text, culture, memory]]></keywords_en><summary_hr><![CDATA[Predloženi će se projekt fokusirati na konstrukciju fikcionalnog i povijesnog vremena u post-jugoslavenskoj prozi. Formiranje temporalnosti povezat će se s literarnim, estetskim, kulturalnim i geopolitičkim konstrukcijama Balkana i post-jugoslavenskoga stanja. Umjesto naziva ‘hrvatska’, ‘bosanska’ ili ‘srpska’ književnost koristit će se naziv ‘post-jugoslavenska’ književnost. Pod nazivom ‘post-jugoslavenski’ podrazumijevat će se iskustvo fragmentacije ranije prihvaćenoga zajedničkog društvenog, kulturalnog i etničkog prostora, neprevodivost kulturalnog, socijalnog i političkog iskustva novonastalih nacionalnih država te iskustvo egzila pisaca koji su, privremeno ili trajno, napustili svoje domovine. Predlaganjem termina ‘post-jugoslavenski’ kao zamjene za nacionalne etikete ukazuje se na vremensko iskustvo transnacionalnosti post-jugoslavenske literature. Politika vremena implicitno prisutna u post-jugoslavenskoj prozi bit će polazišna točka istraživanja. Dosadašnja su se istraživanja fokusirala na tematiku egzila, melankolije, prostora, identiteta (rodnoga, etničkoga, klasnoga) i proizvodne kulture u djelima post-jugoslavenskih pisaca. U većini istraživanja problemi vremena i moderniteta te njihove relacije spram transnacionalne imaginacije u post-jugoslavenskoj prozi bili su tek podrazumijevani, no nikad i eksplicitno istraženi kao važna teorijska tema. Cilj predloženoga projekta je eksplicirati politiku vremena i ulogu vremena u konstituiranju transnacionalnosti u djelima post-jugoslavenskih pisaca. Temporalna konstrukcija transnacionalnoga subjekta i zajednice središnja je tema predloženoga projekta i polazišna točka promišljanja prethodnih istraživanja.]]></summary_hr><summary_en><![CDATA[The proposed project will be focused on the construction of fictional and historical time in the post-Yugoslav prose. The construction of temporality will be related to the literary, aesthetic, cultural and geopolitical construction of the Balkan and post-Yugoslav conditions. With the notion of ‘post-Yugoslav’ it will be referred to the experience of fragmentation of previously common civic, cultural and ethnic space, to the intranslatability of cultural, social and political experience between newly emerged nation-states, exiled life of writers who left (permanently or temporarily) their homelands. By proposing usage of the term ‘post-Yugoslav’, instead of national labels, it will be elaborated the temporal experience of transnationality of post-Yugoslav literature.The politics of time implicitly developed in the post-Yugoslav prose will be taken as a starting point. Scholarship has so far focused on topics of exile, melancholia, space, identity (gender, ethnic, class) and commodity culture in the works of post-Yugoslav writers. However, the problems of time, modernity and their relation to the transnational imagination in the post-Yugoslav prose was only implied in the most of these accounts, and has not been explicated so far as a salient theoretical topic. The aim of the proposed project is to explicate the politics of time and its role in the constitution of transnationality in the works of post-Yugoslav writers. Temporal constitution of transnational subject and community is the central topic of the proposed project and it will be starting point for rethinking the previous research. ]]></summary_en></project><project>
<id>4438</id><title_hr><![CDATA[Patogeneza citomegalovirusne infekcije u jajnicima, utjecaj na plodnost i održavanje trudnoće]]></title_hr><title_en><![CDATA[Pathogenesis of cytomegalovirus infection in the ovaries, impact on fertility and pregnancy maintenance]]></title_en><user_id>4682</user_id><user_firstLast_name>Vanda Juranić Lisnić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-5980</code><acronim><![CDATA[JaPI]]></acronim><duration>01.06.2017 - 31.05.2021</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Medicine]]></institution_en><team_members_id>19694, 19695, 5357, 23779, 28629, </team_members_id><team_members_names><![CDATA[Jelena Tomac, Mijo Golemac, Daria Kveštak, Marija Mazor, Ana Vrbanović Vrbanović, ]]></team_members_names><keywords_hr><![CDATA[citomegalovirus, plodnost, jajnici, trudnoća, progesteron, infekcija, patogeneza, pobačaj]]></keywords_hr><keywords_en><![CDATA[cytomegalovirus, fertility, ovaries, pregnancy, progesterone, infection, pathogenesis, pregnancy-loss]]></keywords_en><summary_hr><![CDATA[Humani citomegalovirus (HCMV) je herpes virus kojim je zaražena većina svjetske populacije. Infekcija HCMV-om opasna je u trudnica: može izazvati pobačaj ili brojne trajne malformacije ploda. Efikasno cjepivo ne postoji, a dostupni lijekovi imaju brojne nuspojave. Infekcija miševa mišjim CMV-om najčešće je korišteni model kojim se istražuje biologija i patogeneza HCMV-a. U našem dosadašnjem radu primijetili smo da MCMV vrlo uspješno inficira jajnike spolno zrelih ženki miševa. Detaljnijom analizom ustanovili smo da je infekcija ograničena na žuta tijela i stromu jajnika. Folikuli, strukture u kojima se čuva jajna stanica do trenutka ovulacije, nisu bili inficirani. Čak i kod infekcije imunosuprimiranog mišjeg soja IFNgamma KO koji slabo kontrolira virus, folikuli su većinom ostali neinficirani unatoč izuzetno snažnoj infekciji žutih tijela i strome. Infekcija žutih tijela može ugroziti trudnoću, a infekcija folikula ugrožava cjelokupni fertilitet jedinke te je razumijevanje mehanizama kojima se folikuli brane od infekcije od izuzetne važnosti. Naša preliminarna istraživanja pokazuju da se folikularne stanice mogu inficirati ex vivo; stoga predlažemo istraživanja kojima bi se utvrdili morfološki i imunološki faktori koji brane folikule od infekcija u jajniku. Razumijevanje mehanizama kojima se folikuli brane od infekcije prirodnim patogenom pomoći će nam u rasvjetljavanju nekih uzroka neplodnosti.Žuta tijela glavni su proizvođači hormona progesterona koji je neophodan za održavanje trudnoće, posebno rane. Naša preliminarna istraživanja pokazuju da infekcija jajnika MCMV-om značajno smanjuje razinu progesterona te bi tako mogla dovesti do pobačaja. Stoga ćemo istražiti mehanizme koji dovode do smanjenja razina progesterona  kao i potencijalni terapeutski učinak davanja progesterona zaraženim trudnim ženkama.Zaključno, predloženo istraživanje predstavlja važan korak ka razumijevanju utjecaja infekcije izuzetno učestalim patogenom na reproduktivno zdravlje.]]></summary_hr><summary_en><![CDATA[Human cytomegalovirus (HCMV) is a herpes virus that infects the majority of world’s population. Infection during pregnancy can lead to pregnancy-loss or numerous developmental disabilities of the fetus. There is no effective vaccine while available treatments have numerous side-effects.Murine CMV infection of mice is the most commonly used model to study the biology and pathogenesis of HCMV. We observed strong infection of the ovaries of sexually mature female mice, in stroma and corpora lutea. Interestingly, the infection was excluded from the ovarian follicles, structures that contain oocytes. Even when very immunosuppressed mouse strain IFNgamma KO was infected, follicles mostly remained uninfected despite nearly complete infection of corpora lutea and stroma. Infection of corpora lutea may endanger ongoing pregnancy while infection of follicles threatens whole reproductive capacity. Therefore, better understanding of mechanisms that protect follicles from naturally occurring infections is of utmost importance. Since our preliminary results show that follicular cells can be infected ex vivo, we propose to investigate morphological and immunological factors that protect the follicles. Understanding the mechanisms that protect the follicles during infection with a natural and pervasive pathogen may help in uncovering etiology of infertility. Corpora lutea are the main producers of progesterone, hormone essential for pregnancy maintenance, especially early. Our preliminary data shows that MCMV infection of ovaries results in significant downregulation of serum progesterone levels which could cause abortions. We therefore wish to investigate the mechanisms behind this downregulation and therapeutic application of exogenous progesterone treatment.In conclusion, the proposed research is an important step in understanding the impact of naturally occurring pervasive pathogen on reproductive health.]]></summary_en></project><project>
<id>4444</id><title_hr><![CDATA[Multimodalni prikaz molekularnih zbivanja tijekom oporavka mišjeg mozga nakon ishemijskog oštećenja]]></title_hr><title_en><![CDATA[Multimodal molecular imaging of the mouse brain repair after ishemic lesion]]></title_en><user_id>7297</user_id><user_firstLast_name>Srećko Gajović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-1892</code><acronim><![CDATA[RepairStroke]]></acronim><duration>01.12.2017 - 30.11.2021</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>12709, 19958, 20098, 7637, 19937, 19920, 6226, 25254, 27600, 861751, </team_members_id><team_members_names><![CDATA[Siniša Škokić, Kristina Šemanjski, Krešimir Sanković, Ivan Bohaček, Ana Hrkać Pustahija, Anton Glasnović, Marina Dobrivojević, Paula Josić, Sanja Srakočić, Rok Ister, ]]></team_members_names><keywords_hr><![CDATA[moždani udar, miš, snimanje magnetskom rezonancijom, snimanje bioluminiscencijom, upala]]></keywords_hr><keywords_en><![CDATA[stroke, mouse, magnetic resonanse imaging, bioluminescence imaging, inflammation]]></keywords_en><summary_hr><![CDATA[Moždani udar predstavlja vodeći zdravstveni problem, te postoji potreba razumijevanja mehanizma oporavka i mogućeg liječenja mozga nakon moždanog udara. Ovim projektom pokušava se razjasniti slijed zbivanja tijekom oporavka mozga primjenom multimodalnog prikaza molekularnih zbivanja u mozgu živog miša. To će se postići primjenom niza modaliteta snimanja živih miševa magnetskom rezonancijom, te pretkliničkim optičkim snimanjem bioluminiscencije. Eksperimentalnim zatvaranjem srednje moždane arterije postići će se ishemijsko oštećenje mišjeg mozga. Procesi koji će biti promatrani uključuju upalu (praćenu bioluminiscencijom Tlr2-luc transgeničnog miša), stvaranje novih nastavaka živčanih stanica (praćenu bioluminiscencijom Gap43-luc transgeničnog miša), apoptozu (praćenu zatočenim DEVD-luciferinom), poremećaj i obnovu povezanosti mozga (difuzijskim tenzornim snimanjem magnetskom rezonancijom), te obnovu perfuzije mozga (označavanjem spina u arterijama tijekom snimanja magnetskom rezonancijom) , čijom kombinacijom se očekuje uočiti kritična molekularna i stanična zbivanja koja djeluju neuroprotektivno i obnavljaju mozak. Snimanja živog miša korelirat će se s funkcionalnim i morfološkim analizama mišjeg mozga mikroskopijom i testovima ponašanja životinja. Ovim će se omogućiti definiranje parametara oporavka mozga u mišjem modelu moždanog udara kako bi se pretklinički provjerili mogući terapijski pristupi i omogućila njihova translacija u kliničke pokuse.]]></summary_hr><summary_en><![CDATA[Stroke is the leading health problem, hence a need to understand the mechanism of recovery and possible treatment of the brain dammaged by stroke. This project attempts to clarify the sequence of events during the brain recovery after ischemic lesion by using in vivo multimodal molecular imaging of the mouse brain. This will be achieved through a combination of imaging modalities including magnetic resonance imaging (MRI), and preclinical optical bioluminescence imaging (BLI). Mouse stroke model of the middle cerebral artery occlusion (MCAO) will result in the ischemic brain damage. The processes that will be monitored include inflammation (visualized by bioluminescence of TLR2-luc transgenic mouse), extension of neuronal processes (visualized by bioluminescence of GAP43-luc transgenic mouse), apoptosis (followed by caged DEVD-luciferin), brain connectivity (MR diffusion tensor imaging), and brain perfusion (MRI arterial spin labeling), which combination is expected to describe critical molecular and cellular events that act neuroprotective and regenerate brain. In vivo imaging will be correlated with functional and morphological analysis of the mouse brain using microscopy and behavioral tests. This will allow to define the preclinical parameters of recovery of the brain in a mouse model of stroke to be used to evaluate possible therapeutic approaches and enable their translation into the clinical trials.]]></summary_en></project><project>
<id>4452</id><title_hr><![CDATA[Racionalnost: između logičkog ideala i svakodnevnog zaključivanja ]]></title_hr><title_en><![CDATA[Rationality: between Logically Ideal and Commonsensical in Everyday Reasoning]]></title_en><user_id>3843</user_id><user_firstLast_name>Majda Trobok</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-2408</code><acronim><![CDATA[RACIO]]></acronim><duration>15.03.2017 - 14.07.2020</duration><status>Završio</status><financ_value>59.458,84 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filozofija, </scie_field_hr><scie_field_en>Philosophy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Filozofski fakultet u Rijeci]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>6429, 4612, 7371, 6529, 19802, 6074, 23262, </team_members_id><team_members_names><![CDATA[Davor Lauc, Igor Bajšanski, Danilo Šuster, Olga Markič, Paolo Labinaz, Martina Blečić, David Grčki, ]]></team_members_names><keywords_hr><![CDATA[racionalnost, logika, zaključivanje, prirodni jezik, argumentacija, kritičko mišljenje]]></keywords_hr><keywords_en><![CDATA[rationality, logic, reasoning, natural language, argumentation, critical thinking]]></keywords_en><summary_hr><![CDATA[Opći je cilj projekta odrediti narav i značajke racionalnosti shvaćene kao kriterij ispravnog zaključivanja. Područje istraživanja čini prostor između jakog normativnog standarda racionalnosti određenog formalnim logičkim pravilima i istraživanja koja nastoje izvesti norme zaključivanja na temelju stvarnog ponašanja ljudi pri rješavanju deduktivnih zadataka. Fokus istraživanja oslanja se na logicistički pristup racionalnosti koji će biti podvrgnut provjeri s obzirom na ponašanje subjekata prilikom svakodnevnog zaključivanja.Kako bi se ostvario taj cilj istraživačke su aktivnosti usmjerene na istraživanja vezana uz četiri teme:1) Prirodni jezik kao medij za deduktivno zaključivanje. Ako su logička pravila barem djelomično normativna za ispravno zaključivanje, važan je podcilj istražiti mogućnosti izražavanja i zrcaljenja logičkih operatora u prirodnome jeziku.2) Uloga individualnih razlika u svakodnevnom zaključivanju. Istaknuta je značajka svakodnevnoga zaključivanja da subjekt zahvaća deduktivni problem u skladu s onim kako ga razumije, stoga je moguća aktivacija različitih mehanizama zaključivanja. Prihvatljivost ove hipoteze značajno će utjecati na raspravu o postojanju jedinstvenog standarda racionalnosti.3) Racionalnost u kontekstu društvenih interakcija, posebno u argumentacijskom procesu. Argumentacijski je proces bitno određen oblikovanjem i procjenjivanjem argumenata, što od sudionika zahtijeva dijeljenje istih komunikacijskih i deduktivnih pravila.4) Pitanje kritičkoga mišljenja određuje područje istraživanja u kojem će sva ranije spomenuta pitanja biti sažeta, analizirana i testirana u kontekstu različitih područja svakodnevnoga života te će dobiveni rezultati poslužiti za formuliranje regulativnih uputa za moguće unaprjeđenje vještina kritičkoga mišljenja.Najznačajnijim se doprinosom projekta može smatrati pokušaj određenja dobro usklađenog standarda racionalnosti smještenog između ideala logičkih pravila i prakse svakodnevnoga zaključivanja.]]></summary_hr><summary_en><![CDATA[The overall goal of the project is to determine the nature and characteristics of rationality understood as a criterion of correct reasoning. The research area is the space between a strong normative standard of rationality determined by formal logical rules and researches that strive to derive norms of reasoning from the actual people’s behavior in solving deductive tasks. The focal point of the investigation relies on the logistic approach to rationality to be tested against subjects’ behavior in everyday reasoning.To reach this goal, research activities will be focused on investigations in four topics:1) Natural language as a media for deductive reasoning. If logical rules are at least partly normative for correct reasoning, the important sub-goal is to investigate natural language’s possibilities to express and mirror logical terms.2) The role of individual differences in everyday reasoning. The salient feature of everyday reasoning is that the subject responds to a deductive problem as he/she understands it, so the activation of a variety of reasoning mechanisms is possible. If this hypothesis can be confirmed, it will significantly contribute to the debate concerning uniqueness or plurality of the rationality standard(s). 3) The rationality of social interactions, particularly in the argumentative process. The argumentative process is determined by the making and assessing of arguments, which requires a mutual recognition of communicative and deductive rules. 4) The issue of critical thinking determines the investigation area in which all mentioned questions could be summarized, analyzed and tested in various fields of everyday life and the obtained results will be used to enable the articulation of prescriptions for a possible improvement of critical thinking skills. The most important contribution of the project can be seen as an attempt to determine the well-balanced standard of rationality placed between ideal logical rules and everyday reasoning practice.]]></summary_en></project><project>
<id>4454</id><title_hr><![CDATA[Precizni izračuni fizikalnih veličina u supersimetričnim modelima fizike čestica]]></title_hr><title_en><![CDATA[Precise computations of physical quantites in supersymmetric particle physics models]]></title_en><user_id>3140</user_id><user_firstLast_name>Amon Ilakovac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-7460</code><acronim><![CDATA[PRECIOUS]]></acronim><duration>31.03.2017 - 31.08.2021</duration><status>Završio</status><financ_value>106.510,05 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>19722, 20093, 856160, </team_members_id><team_members_names><![CDATA[Marija Mađor-Božinović, Dominik Stoeckinger, Hermes Bélusca, ]]></team_members_names><keywords_hr><![CDATA[supersimetrija, algebarska renormalizacija, masa Higgsovog bozona, precizne opservable, nesačuvanje leptonskog broja]]></keywords_hr><keywords_en><![CDATA[supersymmetry, algebraic renormalization, Higgs boson mass, precision observables, lepton flavour violation]]></keywords_en><summary_hr><![CDATA[Najnoviji LHC eksperimenti dali su dva važna nova rezultata. Prvi je izmjerena masa Higgsovog bozona s preciznošću od 0.2 % s time da se u drugoj izvedbi LHC eksperimenta na 13 GeV očekuje dodatno poboljšanje na 0.1 %. Time je masa Higgovog bozona uvrštena u precizne opservable. Drugi rezultat je da nije opažena fizika izvan standardnog modela (SM) ostavljajući podatke o neutrinskim oscilacijama kao jedini akceleratorski dokaz fizike izvan standardnog modela. Time nije osigurano rješenje problema hijerarhije u standardnom modelu. Kao što je dobro poznato rješenje problema hijerarhije u SM poznato je u supersimetričnim teorijama i u jako spregnutim teorijama. Ideja ovog projekta je da razmotri na novi način precizne opservable sa posebnom pozornošću na izračun mase Higgsovog vozona u supersimetričnim modelima (SSM) koji dozvoljavaju neutrinske oscilacije. Zbog najavljenih poboljšanja eksperimentalne osjetljivosti leptonskih dipolnih momenata i opservabli vezanih uz procese s nabijenim leptonima koji narušavaju leptonski okus, proučavat ćemo modele koji dopuštaju ne-zanemarive doprinose spomenutim opservablama kao i druge opservable okusa potisnute u SM. Kako bi se postigli ti ciljevi, istraživanje će se provoditi u dva smjera.  Jedan smjer se odnosi na poboljšanje sadašnjih metoda određivanja parametara mekog narušenja SUSY u  modelima   mekanog narušenja SUSY na visokoj skali. Drugi smjer istraživanja ima za cilj poboljšanje izračuna amaplituda općeg SSM na nivou dviju petlji (i više). Ta poboljšanja primijenit će se na izračun renormalizacijskih grupnih jednadžbi preciznih opservabli i opservabli koje su potisnute ili zabranjene u SM. Rezultati dobiveni za eksperimentalno zanimljive opservable poslužit će da ograniče parametre razmatranih modela.]]></summary_hr><summary_en><![CDATA[The newest LHC experiments gave two important new results. First is the measurement of the Higgs boson mass with precision 0.2 % with a good prospect to be improved to 0.1% via the second run of LHC at 13 GeV enlisting the Higgs boson mass into the precision observables. The second is that no sign of physics beyond standard model has been found, leaving the neutrino oscillations data as only accelerator proof of the physics beyond the standard model, offering no solution for the standard model (SM) hierarchy problem. As is well known the solutions of the hierarchy problem of the standard model are known in supersymmetric theories and strongly coupled theories. The idea of this project is to reconsider the electroweak precision observables with special attention to the precise evaluation of the Higgs boson mass within the supersymmetric models (SSMs) permitting neutrino oscillations. Due to the forthcoming improvements of sensitivities of the lepton dipole moments and the charged lepton flavour violating (LFV) observables the models permitting non-negligible contribution to lepton flavour observables and SM model suppressed flavour observables will be considered. To achieve these goals two pathways will be followed. One is improvement of the present methods for determination of the soft SUSY breaking  parameters in the models with high scale soft SUSY breaking. The other is improvement of evaluation of the amplitudes for general SSMs at two loop (or beyond). These improvements will be applied to evaluation of renormalization group equations, precision observables and SM suppressed and forbidden observables. The results for the experimentally interesting observables will be used to constrain the model parameters.    ]]></summary_en></project><project>
<id>4457</id><title_hr><![CDATA[DNA barkodiranje bioraznolikosti hrvatske faune ]]></title_hr><title_en><![CDATA[DNA barcoding of Croatian faunal biodiversity]]></title_en><user_id>19707</user_id><user_firstLast_name>Mladen Kučinić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-9988</code><acronim><![CDATA[CroBarFauna]]></acronim><duration>01.03.2017 - 31.12.2021</duration><status>Završio</status><financ_value>130.639,06 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>4269, 12386, 12919, 3003, 19798, 129, 19965, 19167, 19840, 19064, 20104, 19618, 19724, 19871, 20101, 19972, 19144, 19063, 28678, 27433, 27422, 27437, 27427, </team_members_id><team_members_names><![CDATA[Martina Podnar Lešić, Jasna Lajtner, Lucija Šerić Jelaska, Branka Bruvo Mađarić, Irena Grbac, Stjepan Krčmar, Darko Cerjanec, Vlatka Mičetić Stanković, Ivan Vučković, Martina Šašić Kljajo, Ignac Sivec, Nikola Tvrtković, Nediljko Landeka, Roman Ozimec, Ana Mrnjavčić Vojvoda, Mauro Štifanić, Anđela Ćukušić, Iva Mihoci, Dora Hlebec, Nataša Graovac, Edin Lugić, Neven Iveša, Moira Buršić, ]]></team_members_names><keywords_hr><![CDATA[DNA barkodiranje, određivanje vrsta, bioraznolikost, kriptične vrste, zaštita]]></keywords_hr><keywords_en><![CDATA[DNA barcoding, species identification, biodiversity, cryptic species, protection]]></keywords_en><summary_hr><![CDATA[Metoda DNA barkodiranja predložena je 2003. godine kao univerzalni sistem za determinaciju biološkog materijala u smislu identifikacije vrste, a također i kao metoda za otkrivanje novih, još neopisanih vrsta koje se ne mogu međusobno razlikovati na temelju morfoloških obilježja (tzv. kriptičnih vrsta). Temelji se na određivanju slijeda nukleotida standardiziranog fragmenta mitohondrijskog gena za podjedinicu I citokrom oksidaze (COI) duljine oko 650 pb.Geografskim smještajem na zapadnom Balkanu i Mediteranu, teritorij Hrvatske predstavlja jednu od europskih „žarišnih točaka biološke raznolikosti“ (biodiversity hotspot). Visoki stupanj bioraznolikosti Hrvatske posljedica je raznolikog sastava staništa, klimatskih i hidroloških značajki kao i kompleksne geološke povijesti regije.Glavni cilj ovog istraživačkog projekta je upotrebom metode DNA barkodiranja steći uvid u opseg i geografsko rasprostranjenje ukupne genetske bioraznolikosti ciljanih skupina faune Hrvatske, te prepoznati vrste koje je neophodno dodatno detaljno istražiti s taksonomskog, filogenetskog i filogeografskog aspekta.U okviru ovog projekta prioritet će biti dan taksonomskim skupinama za koje postoje taksonomski stručnjaci među projektnim suradnicima s već djelomično prikupljenim materijalom, a s druge strane skupine koje su taksonomski potencijalno vrlo zanimljive i za koje je DNA barkodiranje već započeto u okviru ostalih Europskih inicijativa za barkodiranje.Podaci o DNA barkodovima prikupljeni ovim istraživanjem omogućiti će točniju identifikaciju velikog broja vrsta te ukazati na potrebu dodatnih istraživanja pojedinih skupina. Ukazati će vjerojatno i na nove, nepoznate kriptičke, možda i endemske vrste u Hrvatskoj, što bi imalo veliki značaj za razvitak strategija i planova za zaštitu bioraznolikosti u Hrvatskoj. Osim toga rezultati će imati moguću primjenu i u biomonitoringu kao i u epidemiološkim studijama (npr. kontrola štetnika, identifikacija i praćenje prijenosnika bolesti).]]></summary_hr><summary_en><![CDATA[DNA barcoding was proposed in 2003. as a universal system for assignment of specimens to a particular species but also as a tool for recognition of yet undescribed morphologically indistinguishable cryptic species. The method is based on the sequencing of standardized, ~650 bp long fragment of the mitochondrial cytochrome c oxidase subunit 1 gene (COI).Geographically located in the Western Balkan and Mediterranean basin, Croatian territory has great habitat diversity and represents one of the European biodiversity hotspots. High biodiversity index is consequence of very diverse habitats, climatic and hydrological features as well as complex geological history of the region. The primary goal of the proposed research project is to investigate the amount and geographic distribution of the genetic biodiversity of selected groups of Croatian fauna by using DNA barcoding methodology, flagging species for further rigorous taxonomic, phylogenetic and phylogeographic studies.In the frame of the proposed project the priority will be given to potentially taxonomically especially interesting groups, that have taxonomic expert among project collaborators, certain amount of already collected material, and groups for which DNA barcoding is already in progress within other European barcode initiatives.DNA barcodes obtained in this research will enable simple, fast and accurate identification for a great number of species, and flag certain groups for further investigation. They would most probably provide insights in some of still unrecognized or overlooked, cryptic, probably endemic species in Croatia. The assessment will be of primary importance for the development of strategies and action plans for the conservation of biodiversity in Croatia. In addition, these results will also find application in biomonitoring as well as for epidemiological studies (identification and monitoring of disease vectors).]]></summary_en></project><project>
<id>4459</id><title_hr><![CDATA[Mogućnosti reindustrijalizacije hrvatskog gospodarstva]]></title_hr><title_en><![CDATA[Possibilities for reindustrialization of Croatian economy]]></title_en><user_id>4139</user_id><user_firstLast_name>Nebojša Stojčić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-3764</code><acronim><![CDATA[REINDUCE]]></acronim><duration>01.01.2017 - 31.12.2019</duration><status>Završio</status><financ_value>39.737,21 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, </scie_field_hr><scie_field_en>Economy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Dubrovniku]]></institution_hr><institution_en><![CDATA[University of Dubrovnik]]></institution_en><team_members_id>5973, 20159, 189, 20133, 5713, 20280, 25381, </team_members_id><team_members_names><![CDATA[Perica Vojinić, Katarina  Bačić, Ivan-Damir   Anić, Tonći Svilokos, Zoran  Aralica, Meri Šuman Tolić, Slavo Radosevic, ]]></team_members_names><keywords_hr><![CDATA[reindustrijalizacija, inovacije, poduzetništvo, FDI, međunarodna trgovina, institucije]]></keywords_hr><keywords_en><![CDATA[reindustrialization, inovations, entrepreneurship, FDI, international trade, institutions]]></keywords_en><summary_hr><![CDATA[Pretpostavka projekta REINDUCE je da završetak ekonomske integracije Hrvatske u EU zahtijeva značajnu konvergenciju produktivnosti i zaposlenosti prema prosjeku zemalja EU. Koncept kojega podržava REINDUCE je nova industrijska politika, prilagođena hrvatskim specifičnostima i aktualnostima. Tijekom proteklih dvadeset godina Hrvatska je prošla značajnu deindustrijalizaciju i u ovome trenutku mora pronaći svoj specifičan model reindustrijalizacije koji uzima u obzir vlastita povijesna i kulturna obilježja. Ti se izazovi analiziraju kroz sljedeća ključna područja: izvore, opseg i posljedice deindustrijalizacije, institucionalne promjene, inovacije, poduzetništvo i razvoj malih i srednjih poduzeća; međunarodnu trgovinu, izravna strana ulaganja i globalne lance vrijednosti; promjene ekonomske politike i institucionalne reforme. REINDUCE projektom ostvarit će se znatan iskorak u razumijevanju mikroekonomske dinamike hrvatskoga gospodarstva, a razumijevanje te dinamike je od presudne važnosti za buduće izglede rasta unutar EU. To će pružiti bolje i dublje razumijevanje ne-tržišnih prepreka i tržišnih neuspjeha iz raznih gospodarskih perspektiva, koje su potrebne da se ponište učinici dosadašnje nepovoljne deindustrijalizacije s ciljem poticanja procesa sustizanja naprednih nacionalnih gospodarstava. Predmet analize REINDUCE predstavlja jedan od najvažnijih pokušaja razmatranja ekonomske politike u Hrvatskoj danas: razumijevanje od razloga trenutnog ekonomskog stanja i kao i razvoj analitičkih alata zasnovanih na dokazima za kreatore ekonomske politike kao i prelazak sa deindustrijalizacije ka reindustrijalizaciji i promicanje procesa dostizanja prelaskom ka ekonomskim aktivnostima s visokom dodanom vrijednošću i znanjem intenzivnim aktivnostima. Ishod ovog projekta bit će nova istraživanja kojima je svrha produbiti razmišljanja o ekonomskoj politici, kao i preporuke zasnovane na nalazima i na širokome rasponu povezanih politika i alata.]]></summary_hr><summary_en><![CDATA[The premise of REINDUCE project is that the completion of economic integration of Croatia in EU requires rapid convergence of productivity and employment levels towards the EU average. Therefore, the overall concept underpinning REINDUCE is the new industrial policy adapted to the specificities and realities of Croatia.  Over past twenty years Croatia faced massive deindustrialization and needs to find its own specific model of reindustrialization which takes into account its own historical and cultural characteristics. These challenges are analysed through the following key areas: sources, extent and implications of deindustrialization; institutional changes and corporate governance, innovation, entrepreneurship and SME development; international trade, foreign investment and global value chains; policy changes and institutional reforms. The project will make a substantial step forward in understanding the microeconomic dynamics of the Croatian economy whose understanding is of crucial importance for its future growth prospects within the EU. It will provide a better and deeper understanding of non-market obstacles and market failures from a variety of economic perspectives, which are required to reverse the severe deindustrialization and to boost the catching-up process. The subject matter of REINDUCE represents one of the most important policy considerations of Croatia today: the understanding of the reasons behind the current economic state and the developing evidence-based tools for policy-makers to reverse de-industrialisation to re-industrialisation and to boost catching-up process by shifting economic activities to high value-added, knowledge-based activities. The outcome of this project will be new research to deepen the thinking on economic policy together with evidence-based recommendations on a wide range of linked policies and tools. ]]></summary_en></project><project>
<id>4463</id><title_hr><![CDATA[Preparation of Porous Thin-film Materials for water Purification using Atomic Layer Deposition (ALD)]]></title_hr><title_en><![CDATA[Priprema poroznih tankoslojnih materijala za pročišćavanje vode koristeći tehniku Depozicije atomskih slojeva (ALD)]]></title_en><user_id>20047</user_id><user_firstLast_name>Gabriela Ambrožić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-3568</code><acronim><![CDATA[WATPUR]]></acronim><duration>10.04.2017 - 09.09.2021</duration><status>Završio</status><financ_value>129.734,62 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, Fizika, </scie_field_hr><scie_field_en>Chemistry, Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Fakultet za fiziku]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Physics]]></institution_en><team_members_id>19797, 19539, 20255, 20190, 19892, 3948, 116, </team_members_id><team_members_names><![CDATA[Mato Knez, Ivana Jelovica Badovinac, Iva Šarić, Robert Peter, Ivna Kavre Piltaver, Karlo Wittine, Ivana Gobin, ]]></team_members_names><keywords_hr><![CDATA[Pročišćavanje vode, porozni tanki filmovi, Uređaj za depoziciju atomskih slojeva (ALD), &#39;&#39;klik&#39;&#39; kemija, fotokataliza]]></keywords_hr><keywords_en><![CDATA[Water purification, porous thin films, Atomic layer deposition (ALD), &#39;&#39;click&#39;&#39; chemistry, photocatalysis]]></keywords_en><summary_hr><![CDATA[Specifični cilj predloženog projekta je priprema novih fotoaktivnih keramičkih tankih filmova s kontroliranom debljinom i dobro definiranim poroznim strukturama s izrazitom primjenom za pročišćavanje vode od organskih i bioloških zagađivača.U projektu se istražuju novi pristupi u sintezi ovih materijala, koristeći tehniku Depozicije atomskih slojeva (Atomic layer deposition - ALD) u kombinaciji s visoko selektivnom „klik“ kemijom, koji će unaprijediti osnovna znanja i razviti inovacije u sintezi materijala za primjenu u pročišćavanju vode zelenim tehnologijama. Sintetski i post-sintetski procesi su osmišljeni za dobivanje materijala s naprednom funkcionalnošću koja će omogućiti: smanjenje troškova tehnologija pročišćavanja voda kroz primjenu solarne energije, selektivnu adsorpciju organskih i bioloških zagađivača, foto-induciranu desorpciju organskih zagađivala, foto-induciranu razgradnju organskih onečišćujućih tvari i učinkovitu regeneraciju te ponovno korištenje tankoslojnih materijala.Ovi novi keramički materijali se razlikuju od tradicionalnih materiala i procesa za pročišćavanje i dezinfekciju vode upravo zbog sintetskih postupaka koje ćemo primijeniti, a koji će omogućiti narastanje potpuno novog tipa višenamjenskih keramičkih filmova deponiranih na biorazgradivom tekstilu / pamuku i anorganskim makroporoznim podlogama. Spomenute karakteristike će proširiti potencijal keramičkih materijala u različitim smjerovima primjene: od dekontaminacije mora od naftnih izlijeva do sustava za pročišćavanje pitke vode.]]></summary_hr><summary_en><![CDATA[The specific objective of the proposed project is to prepare novel materials for purification of water from organic and biological contaminants, based on photoactive ceramic thin-films with controllable inorganic film thickness and well-defined porous structures. The project explores a new approach in synthesis of these materials using atomic layer deposition (ALD) technique in combination with highly selective “click” chemistry that will advance the fundamental knowledge and develop innovations in synthesis of materials for potential applications in green-technology water purification. The synthetic and post-synthetic processes are designed in such a way that the advanced functionalities of these materials are expected to reduce the cost of water purification treatment through the application of solar energy, selective adsorption of organic and biological pollutants, photo-induced desorption of organic pollutants, photo-induced degradation of organic pollutants and effective regeneration and re-use of thin-film materials. The novel ceramic materials will differ from the conventional water disinfection and purification materials and processes as the applied procedures will give access to an entirely new class of multifunctional ceramic films deposited on biodegradable textile/cotton and inorganic macroporous substrates. These features will extend the potential of ceramic materials in different application directions: from seawater decontamination upon oil spilling to potable water purification systems. ]]></summary_en></project><project>
<id>4470</id><title_hr><![CDATA[Utjecaj prehrambenih vlakana na bioraspoloživost polifenola istraživanjem adsorpcije i simuliranih probavnih procesa, in vitro]]></title_hr><title_en><![CDATA[The influence of dietary fiber on bioaccessibility of polyphenols by studying adsorption and simulated digestion processes, in vitro]]></title_en><user_id>7376</user_id><user_firstLast_name>Lidija Jakobek</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-6777</code><acronim><![CDATA[BIO-POLIFENOL]]></acronim><duration>01.03.2017 - 30.06.2021</duration><status>Završio</status><financ_value>72.011,41 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Prehrambena tehnologija, Nutricionizam, </scie_field_hr><scie_field_en>Food technology, Nutrition, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Prehrambeno-tehnološki fakultet]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Food Technology]]></institution_en><team_members_id>19843, 7424, 4661, 19154, 19959, 25258, </team_members_id><team_members_names><![CDATA[Petra Krivak, Ivana Tomac, Šime Ukić, Martina Skendrović Babojelić, Andrew Barron Barron, Jozo Ištuk, ]]></team_members_names><keywords_hr><![CDATA[adsorpcija, bioraspoloživost, b-glukan, prehrambena vlakna, polifenoli, bioaktivnosti]]></keywords_hr><keywords_en><![CDATA[adsorption, bioaccessibility, b-glucan, dietary fiber, polyphenols, bioactivities]]></keywords_en><summary_hr><![CDATA[Ranijim istraživanjima pokazalo se da polifenolni spojevi imaju razne bioaktivnosti. Od antioksidacijskog djelovanja do modulacije enzima, djelovanja metabolita polifenola, interakcija s mikroflorom te interakcija s makromolekulama prisutnima u hrani. Sve ove bioaktivnosti mogu zajedno objasniti potencijalno pozitivan utjecaj polifenola na zdravlje. U zadnje vrijeme pažnja se posvećuje interakcijama s makromolekulama u hrani jer one mogu utjecati na bioraspoloživost polifenola. Bioraspoloživost se definira kao količina nutrijenata koji su raspoloživi za apsorpciju u probavnom traktu. Ukoliko polifenoli kroz interakcije s molekulama iz hrane bivaju “zarobljeni” (vezani) za molekule to može utjecati na raspoloživost za njihovu apsorpciju te na njihovo djelovanje u organizmu. Prehrambena vlakna imaju potencijal  vezanja polifenola te ih na taj način mogu zaštititi od razgradnje i prenijeti u donje dijelove probavnog trakta. To može utjecati na bioraspoloživost, ali imati i druge potencijalno pozitivne efekte – polifenoli mogu u izvornom obliku pokazati pozitivne bioaktivnosti u donjim dijelovima probavnog trakta. U ovom projektu cilj je istražiti bioraspoloživost polifenola kroz dva procesa. Prvi bi bio istraživanje procesa adsorpcije polifenola na prehrambenim vlaknima (b-glukan). U ovom dijelu istraživala bi se adsorpcija polifenolnih standarda na prehrambena vlakna (b-glukan) te utjecaj pH, temperature i vremena na adsorpciju. Preko adsorpcije bi se interpretirale interakcije koje se mogu dogoditi između polifenola i prehrambenih vlakana. Drugi proces koji bi se istraživao bio bi simulirani probavni proces, in vitro, u kojem bi se simulirali probavni procesi te istraživala količina polifenola (iz voća) u izvornom obliku nakon probave te utjecaj prehrambenih vlakana na ovaj proces. Rezultatima iz istraživanja adsorpcije i simuliranih probavnih procesa interpretirala bi se bioraspoloživost polifenola te utjecaj prehrambenih vlakana na bioraspoloživost.]]></summary_hr><summary_en><![CDATA[Previous studies have shown that the polyphenolic compounds have various bioactivities: from antioxidant activity to the modulation of enzymes, the action of polyphenol metabolites, interaction with the microflora, and interactions with macromolecules present in food. All of these bioactivities can together explain a potentially positive effect of polyphenols on health. Lately, attention is paid to interactions with macromolecules in food because they can affect the bioaccessibility of polyphenols. Bioaccessibility is defined as the amount of nutrients available for absorption in the gastrointestinal tract. If polyphenols through interaction with molecules from food are &#39;&#39;captured&#39;&#39; (linked) to molecules that can affect the availability for their absorption and their effects in the body. Dietary fibers have the potential to bind polyphenols. Polyphenols can thus be protected from degradation and transferred to the lower parts of intestinal tract. This may affect the bioaccessibility, or have other potentially positive effects - polyphenols may in their original form show positive bioactivities in the lower digestive tract. In this project, the goal is to explore the bioaccessibility of polyphenols through two processes. The first will be the study the adsorption of polyphenols onto dietary fiber (b-glucan), along with the impact of pH, temperature and time on this process. Through adsorption, the interactions that can occur between polyphenols and dietary fiber could be interpreted. Another process that will be studied is the simulated digestion process, in vitro, which would simulate the digestive processes, explore the amount of polyphenols (in fruit) in its original form upon digestion, and the effect of dietary fiber on this process. The results from the adsorption and simulated digestive processes would be used to interpret bioaccessibility of polyphenols and the impact of dietary fiber on bioaccessibility.]]></summary_en></project><project>
<id>4472</id><title_hr><![CDATA[Fizika teraskale na LHC-u i u svemiru]]></title_hr><title_en><![CDATA[Terascale Physics for the LHC and Cosmos]]></title_en><user_id>19131</user_id><user_firstLast_name>Oleg Antipin</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-4418</code><acronim><![CDATA[TsPhLC]]></acronim><duration>01.03.2017 - 31.05.2021</duration><status>Završio</status><financ_value>83.084,48 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>3243, 2665, 19929, 25341, 25595, </team_members_id><team_members_names><![CDATA[Ivica Picek, Blaženka Melić, Francesco Sannino, Jahmall Matteo Bersini, Alessio  Maiezza, ]]></team_members_names><keywords_hr><![CDATA[neutrinske mase, asimptotskih sigurnih teorija, LHC, Standardnog modela,kosmologija]]></keywords_hr><keywords_en><![CDATA[neutrino mass, asymptotically safe theories, LHC, Standard Model, cosmology]]></keywords_en><summary_hr><![CDATA[Europska zajednica je uložila mnogo u razvoj LHC (Velikog hadronskog sudarača čestica) da bi se rješili neki osnovni problemi u fizici visokih energija. LHC Run-2 period koji upravo počinje bi se mogao pokazati kao najuzbudljivije vrijeme u fizicičestica u 21. stoljeću jer postoje naznake za postojanje novih čestica iz ranijih podataka s LHC-a. Ovaj prijedlog projekta će doprinjeti rješavanju fundamentalnih problema unutar fizike visokih energija u svjetlu novih LHC podataka. Cilj ovog projektnog prijedloga je da se dotaknu problemi proširenjem Standardnog modela (SM) jakih, slabih i elektromagnetskih interakcija koje su trenutno prihvačeni teorijski okvir za opisivanje fundamentalnih interakcija elementarnih čestica.Glavni kriterij za uspjeh je dovoljno poznavanje novih eksperimentalnih podataka od strane jakog teorijskoj tima vodećih svjetskih znanstvenika koji rade na povezivanjuizmeđu računa na superračunalnim rešetkama, teorijskih metoda teorije polja, fizike izvan SM i kozmologije. Zajedno sa svojim timom, doprinjet ću različitim relevantnim tehnikama isposobnošću da generiram svoja vlastita istraživanja što je dokazano mojim trenutnim postignutim znanstvenim rezultatima u postojećim suradnjama širom svijeta. Projekt ima četiri faze: 1. Prvo ćemo istražiti novu paradigmu asimptotske sigurnosti proširenja SM s glavnim ciljem formuliranja novih predviđanja za LHC Run-2. 2. S tim novim predviđanjima, cilj nam je proučavati temeljni problem masaneutrina. 3. U ovoj fazi, planiramo obaviti fenomenološke analize tih novih teorija koje vode do točnih predviđanja na ubrzivačima čestica. 4. Konačno, cilj nam je istraživati kozmološke posljedice tih novih modela s težištem naproučavanje tamne materije i bariogeneze.]]></summary_hr><summary_en><![CDATA[The European Community has invested heavily in the Large Hadron Collider (LHC) to solve fundamental problems within high energy physics. The LHC Run-2 period that begins now may prove to be the most exciting time for particle physics in 21th century as there are indications for existence of the new particles from the earlier LHC data. This proposal will contribute to solutions of fundamental problems within high energy physics in light of the new LHC data. The aim of this proposal is to address these problems by extending the Standard Model (SM) of strong, weak and electromagnetic interactions which is the currently accepted theoretical framework to describe interactions of fundamental particles. This is interesting because existing unsolved fundamental problems require new, beyond SM physics.The main criteria for success is a thorough understanding of the new experimental data by the strong theoretical team of the world’s leading researchers working at the interface between lattice supercomputing, field theoretical methods, beyond SM physics and cosmology.Together with my team, I will contribute with a variety of relevant techniques and ability to generate my own research proven by scientific results I currently achieved with existing collaborations worldwide.The project has four phases:1. First I will explore the new paradigm of the asymptotically safe extensions of the SM with the main goal to formulate new predictions for the LHC Run-2.2. With these new predictions, I aim to study the fundamental problem of neutrino mass.3. In this phase, I plan to perform phenomenological analysis of these new theories leading to accurate predictions for colliders.4. Finally, I aim to investigate cosmological implications of these new models with main focus on dark matter and baryogenesis.]]></summary_en></project><project>
<id>4473</id><title_hr><![CDATA[Značaj interakcija metalnih nanočestica sa sumpornim biomolekulama za nano-bio sučelje ]]></title_hr><title_en><![CDATA[Interaction of metallic nanoparticles with sulphur-containing biomolecules - implications for nano-bio interface ]]></title_en><user_id>573</user_id><user_firstLast_name>Ivana Vinković Vrček</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-2436</code><acronim><![CDATA[NanoFaceS]]></acronim><duration>15.03.2017 - 14.03.2021</duration><status>Završio</status><financ_value>120.090,25 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, Biologija, </scie_field_hr><scie_field_en>Chemistry, Biology, </scie_field_en><institution_hr><![CDATA[Institut za medicinska istraživanja i medicinu rada]]></institution_hr><institution_en><![CDATA[Institute for Medical Research and Occupational Health]]></institution_en><team_members_id>1223, 19873, 489, 549, 19641, 19592, 19620, 6307, 19860, 19818, 19612, 1503, 24035, 24031, 25203, </team_members_id><team_members_names><![CDATA[Mirta Milic, Sandra Šupraha Goreta, Goran Šinko, Ivan  Pavičić, Ante Miličević, Marija Milić, Barbara Vuković, Vatroslav Šerić, Daniel Horak, Enisa Omanović-Mikličanin, Ivona Capjak, Walter Goessler, Barbara Pem, Krunoslav Ilić, Rinea Barbir, ]]></team_members_names><keywords_hr><![CDATA[metalne nanočestice, sumporne biomolekule, nanomedicina, interakcije, vezanje]]></keywords_hr><keywords_en><![CDATA[metallic nanoparticle, sulphur containing biomolecules, nanomedicine, interactions, binding]]></keywords_en><summary_hr><![CDATA[Nanomedicina kao područje primjene nanotehnologije u razvoju zaštite zdravlja ima veliki utjecaj na razvoj inovativnih medicinskih tretmana i terapija. Primjena nanočestica (NP) ima ogroman potencijal za učinkovitiju isporuku lijekova i gena, u razvoju fluorescentnih i kontrastnih dijagnostičkih alatki u medicini. ...Međutim, opsežna in vivo primjena NP zahtijeva iscrpnije istraživanje fizikalno-kemijskih i fizioloških procesa koji se odvijaju u biološkim uvjetima. Takvo &#39;nano-bio&#39; sučelje obuhvaća dinamičke fizikalno-kemijske interakcije, te kinetiku i termodinamiku razmjene između površine nanočestica i bioloških površina. ...Nemoguće je potpuno opisati sve čimbenike značajne za to sučelje, ali su za daljnji razvoj nanomedicine nužne dodatne informacije o specifičnim interakcijama nanočestica s bioaktivnim komponentama prisutnim u živim stanicama i tkivima. Glavni cilj predloženog NanoFaceS projekta je pružiti nove  informacije o prirodi &#39;&#39;nano-bio &#39;sučelja između metalnih teranostičkih nanomaterijala i biomolekula koje sadrže sumpor (S-biomolekula), a koje imaju važnu i  kompleksnu funkcionalnu ulogu u živim sustavima. ...Modelni sustav NanoFaceS projekta čini (i) skup nanočestica s jezgrom od srebra, zlata i željezovog oksida,  različitih fizikalno kemijskih svojstava (veličine, površinskog naboja i kemijskog sastava) i (ii)  šest važnih S-biomolekula: cistein, glutation, metalotionein, albumin i inzulin. ... Konceptualni temelj predloženog projekta jest multimetodološki i multidisciplinarni pristup koji će pružiti nove uvide u prirodu specifičnih bioloških interakcija NP sa S-biomolekulama. Projekt će na taj način značajno doprinijeti znanju potrebnom za daljnji razvoj nanomedicinskog područja..........]]></summary_hr><summary_en><![CDATA[Nanomedicine, the application of nanotechnology to healthcare, has great impact on innovation of medical treatments and therapies. Nanoparticles (NPs) have an enormous potential in the medical arena as drug and gene delivery vehicles, fluorescent labels and contrast agents. ...However, extensive in vivo applications of NPs require a more exhaustive exploration of the physicochemical and physiological processes coupled with introduction of NPs to biological environments. The dynamic physicochemical interactions, kinetics and thermodynamic exchanges between NPs surfaces and the surfaces of biological components give rise to the ‘nano–bio’ interface. It is impossible to inevitably describe all events at this interface, but additional information on the more specific interplay of NPs with bioactive components of living cells and tissues are of the highest relevance for prospective evolution of nanomedicine....Proposed NanoFaceS project aims to provide a body of new information and new knowledge to the nanomedical endeavor in addressing the scientific uncertainties related to the beyond-state-of-the-art interaction of engineered metal-based NPs, used in theranostics, and sulfur-containing biomolecules (S-biomols), important in living systems due to their complex functional roles. NanoFaceS will use model system comprising (i) a set of silver, gold and iron oxide NPs with varying physico-chemical properties, i.e. size, surface charge and chemical composition and (ii) six representative S-biomols: cysteine, glutathione, metallothionein, albumin and insulin. ...The underlying concept of NanoFaceS will be based on understanding of interactions between NPs and S-biomols by implementing multimethodological and multidisciplinary approach which would yield competence on biological consequences of NPs interaction with S-biomols. As a major outcome, project will provide substantial knowledge to the nanomedical landscape....]]></summary_en></project><project>
<id>4474</id><title_hr><![CDATA[Metode i algoritmi za poboljšanje slika u boji u stvarnom vremenu]]></title_hr><title_en><![CDATA[Methods and algorithms for real-time color image enhancement]]></title_en><user_id>5393</user_id><user_firstLast_name>Sven Lončarić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-2092</code><acronim><![CDATA[PerfectColor]]></acronim><duration>01.03.2017 - 28.02.2021</duration><status>Završio</status><financ_value>123.963,10 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, Računarstvo, </scie_field_hr><scie_field_en>Electrical engineering, Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>6631, 25373, </team_members_id><team_members_names><![CDATA[Marko Subašić, Karlo Koščević, ]]></team_members_names><keywords_hr><![CDATA[obrada slike, poboljšanje slike, konstantnost boja, preslikavanje tonova, balans bijele boje]]></keywords_hr><keywords_en><![CDATA[image processing, image enhancement, color constancy, tone mapping, white balance]]></keywords_en><summary_hr><![CDATA[Poboljšanje slika u boji je važan problem u mnogim primjenama obrade slika. Razvoj senzora slike i rastuće potrebe tržišta za naprednim rješenjima koja su temeljena na tehnologijama obrade slika su glavni razlozi za sve veću važnost tehnika za poboljšanje slika. Algoritmi za obradu slika koji se koriste u ugradbenim računalnim sustavima kao što su digitalne kamere imaju oštra ograničenja s obzirom na rad u stvarnom vremenu te ograničenja tehnologije korištene za sklopovsku implementaciju, kao npr. FPGA tehnologija. Većina metoda i algoritama objavljenih u literaturi nisu prikladni za rad u stvarnom vremenu zbog njihove složenosti ili jer su neprikladni za sklopovsku izvedbu. Sveukupni cilj projekta je unaprjeđenje dviju važnih operacija za poboljšanje slika, algoritama za postojanost boja i preslikavanja intenziteta slike, koji su prisutni  u mnogim ugradbenim sustavima kao što su npr. digitalne kamere, kroz razvoj novih metoda za rad u stvarnom vremenu koje se i sklopovski daju učinkovito ostvariti. Glavni ciljevi ovog prijedloga su istraživanje i razvoj 1) metoda za postojanost boja koje rade u stvarnom vremenu i 2) metoda za preslikavanje intenziteta slike za rad u stvarnom vremenu. Uz to, bit će razvijene dvije nove baze slika koje će imati važan utjecaj na cijelu istraživačku zajednicu u području postojanosti boja. ]]></summary_hr><summary_en><![CDATA[Color image enhancement is an important problem in many image processing applications. Development of image sensors and growing market demand for advanced solutions that are based on the image processing technology are the main factors for increasing importance of image enhancement techniques. In particular, image processing algorithms used for embedded systems such as digital cameras have strict requirements in terms of real-time operation and hardware constraints imposed by specific technology used for embedded implementation, such as FPGA technology. Most methods and algorithms published in the literature are not suitable for real-time operation due to their complexity or due to being hardware unfriendly so their embedded implementations are too complex and unable to satisfy strict requirements of real-time applications. The overall goal of this project proposal is to improve two important image enhancement tasks of color constancy and tone mapping found in many embedded systems such as digital cameras by proposing new practically implementable methods that are capable of real-time operation. The main objectives of this research proposal are research and development of: 1) methods for real-time color constancy, and 2) methods for real-time tone mapping. In addition, two new image datasets that are to be created during this research, will certainly have an important impact on the whole research field of color constancy.]]></summary_en></project><project>
<id>4476</id><title_hr><![CDATA[Aktivnošću i in silico usmjeren dizajn malih bioaktivnih molekula]]></title_hr><title_en><![CDATA[Activity and in silico guided design of bioactive small molecules]]></title_en><user_id>5462</user_id><user_firstLast_name>Tomica Hrenar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-3775</code><acronim><![CDATA[ADESIRE]]></acronim><duration>01.03.2017 - 28.02.2021</duration><status>Završio</status><financ_value>127.413,90 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>346, 19438, 19981, 5956, 6212, 20037, 19889, 25320, 28772, </team_members_id><team_members_names><![CDATA[Ines Primožič, Alma  Ramic, Linda  Mastelić, Renata  Odžak, Mirjana Skočibušić, Ricardo André Fernandes da Mata, Karlo Sović, Zlatan Spahić, Ana Mikelić, ]]></team_members_names><keywords_hr><![CDATA[dizajn bioaktivnih molekula, sinteza, bioaktivnost, molekularno modeliranje, doking, multi-way analiza]]></keywords_hr><keywords_en><![CDATA[design of bioactive small molecules, synthesis, bioactivity, molecular modelling, docking, multi-way analysis]]></keywords_en><summary_hr><![CDATA[U ovom projektu predložena je sinteza, karakterizacija i biološka evaluacija novih tipova spojeva te ekstenzivni kvantno-kemijski proračuni i multi-way analize. Bioaktivni kemijski skeletni tipovi kao što su benzimidazoli, imidazoli i kinuklidini prepoznati su kao spojevi sa širokim spektrom bioloških aktivnosti, također i u području infektivnih bolesti te poremećaja središnjeg živčanog sustava (Alzheimerova bolest, AD). Mi predviđamo da bi daljnja istraživanja tih klasa kemijskih spojeva mogla rezultirati s identifikacijom novih spojeva prikladnih za daljnji razvoj u moguće lijekove. Kao jako inovativni dio ovog istraživanja, a za razvoj točnih kvantitativnih modela povezivanja strukture i reaktivnosti bit će korištene napredne metode molekularnog modeliranja u kombinaciji s multi-way analizama. Ti modeli će se iskoristiti za iterativni postupak usmjerenog racionalnog dizajna. U početku će se korištenjem klasičnih i suvremenih metoda organske kemije sintetizirati novi bioaktivni spojevi. Za priređene kiralne spojeve odredit će se stereoselektivnost njihovih interakcija. Za sve spojeve, odredit će se antimikrobna aktivnost osobito prema rezistentnim Gram-negativnim bakterijama. Nadalje, njihov potencijal za razvoj poboljšanih lijekova za AD odredit će se mjerenjem njihove inhibicije kolinesteraza. Za procjenu mogućih pozitivnih sinergijskih učinaka, sintetizirat će se hibridne molekule te će se testirati i smjese najaktivnijih sintetiziranih spojeva. Molekularno modeliranje, doking simulacije i novorazvijena metodologija za primjenu multi-way analiza na kombinirane eksperimentalne i teorijske podatke koristit će se za ciljane strukturne promjene koje bi mogle dovesti do novih i efikasnijih bioaktivnih skeletnih tipova s potencijalnom primjenom u biotehnologiji, farmaceutskoj industriji i medicini.]]></summary_hr><summary_en><![CDATA[In this project synthesis, characterization, and biological evaluation of novel types of compounds including extensive quantum chemical calculations and multi-way analyses is proposed. Bioactive chemical scaffolds such as benzimidazoles, imidazoles, and quinuclidines are recognized as compounds with a broad spectrum of biological activities also in the fields of infectious diseases and central nervous system disorders (Alzheimer’s disease, AD). We envisioned that further exploration of these chemical classes can result with the identification of new leads suitable for further development into potential hits. As a highly innovative part of this study, advanced methods of molecular modelling combined with multi-way analysis will be used for construction of accurate quantitative structure–activity relationship models. These models will be used for iterative procedure of guided rational design. Initially, new bioactive compounds will be synthesized using classical and contemporary methods of organic chemistry. Chiral compounds will be prepared and the stereoselectivity of interactions evaluated. For all compounds, antimicrobial activity will be estimated targeting resistance genes to treat infections caused by multidrug-resistant Gram-negative bacteria. Furthermore, their perspective for development of enhanced anti-AD drugs will be assessed by determining their inhibitory potency toward cholinesterases. To evaluate possible beneficial synergistic effects, hybrid molecules as well as various combinations of the most active synthesized compounds will be prepared and tested. Molecular modelling, docking studies and a newly developed method for application of multi-way analysis to combined experimental and theoretical data will be used to direct structural changes leading to the synthesis of new, more efficient bioactive scaffolds with potential use in biotechnology, pharmaceutical industry and medicine.]]></summary_en></project><project>
<id>4481</id><title_hr><![CDATA[Napredno računalno modeliranje s ciljem smanjenja emisija razvojem Eulerove višefazne metode]]></title_hr><title_en><![CDATA[Advanced Computer Modelling for Emission Reduction by development of the Eulerian multiphase method]]></title_en><user_id>5040</user_id><user_firstLast_name>Milan Vujanović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-1488</code><acronim><![CDATA[ACMER]]></acronim><duration>01.04.2017 - 31.03.2021</duration><status>Prekinut</status><financ_value>118.762,70 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, Računarstvo, </scie_field_hr><scie_field_en>Mechnical engineering, Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>17236, 19762, 19763, 19760, </team_members_id><team_members_names><![CDATA[Tomaž Katrašnik, Marko Ban, Hrvoje Mikulčić, Zvonimir Petranović, ]]></team_members_names><keywords_hr><![CDATA[Računalne Simulacije, Višefazno strujanje, Sprej, Izgaranje, Emisije]]></keywords_hr><keywords_en><![CDATA[Computational Simulations, Multiphase flow, Spray, Combustion, Emissions]]></keywords_en><summary_hr><![CDATA[Kao rezultat izgaranja fosilnih goriva velika količina štetnih emisija ispušta se u atmosferu. Jedan način za smanjenje tih emisija je razvoj novih tehnologija izgaranja s poboljšanom učinkovitošću što se može postići kroz optimizaciju procesa raspršivanja i izgaranja goriva. Nadalje, s ciljem smanjenja emisija sve više značaja dobiva djelomična zamjena fosilnih goriva s novim gorivima kao što su biogoriva koja se smatraju CO2 neutralnima. Glavni cilj projektnog prijedloga je razvijanje napredne 3D računalne metode za simuliranje turbulentnih reaktivnih višefaznih strujanja. Predloženo istraživanje započet će razvojem i unaprjeđenjem modela raspadanja mlaza goriva, modela raspadanja i sudaranja kapljica te modela izgaranja goriva. Razvoj računalnih matematičkih modela predstavlja jednu od najsuvremenijih metoda u razvoju novih tehnologija izgaranja s poboljšanom učinkovitošću i smanjenim utjecajem na okoliš. Svi matematički modeli bit će razvijani unutar Euler Eulerovog višefaznog pristupa, što u kombinaciji s detaljnim kemijskim mehanizmima za opisivanje procesa izgaranja, čini novu i jedinstvenu metodu rješavanja višefaznih reaktivnih strujanja. S obzirom na trenutačno korištene metode, novo razvijena metoda bolje će opisivati procese u području gustog spreja što će rezultirati pouzdanim opisivanjem procesa izgaranja i stvaranja štetnih emisija. Novo razvijena metoda omogućit će detaljno modeliranje realnih inženjerskih sustava izgaranja. Rezultati dobiveni ovim projektom namijenjeni su razvoju novih tehnologija i konkretnom smanjenju emisija polutanata iz sektora industrije i transporta. Konačno, rezultati istraživanja bit će dostupni hrvatskom gospodarstvu te će se moći iskoristiti za unaprjeđenje njegove konkurentnosti na globalnom tržištu.]]></summary_hr><summary_en><![CDATA[As a result of fossil fuel combustion a vast amount of harmful pollutant emissions is released into the atmosphere. One way to reduce such emissions is the development of new combustion technologies with increased efficiency, which can be achieved through optimization of fuel spray and combustion processes. Furthermore, with aim to reduce emissions, more and more significance is given to partial fossil fuel replacement with new fuels such as bio-fuels which are considered CO2 neutral. The main goal of project is the development of an advanced 3D computational method for simulating turbulent reactive multiphase flows. The proposed project will start with development and enhancement of the mathematical models of jet atomization, droplet atomization, droplet collision and fuel combustion. The development of computer mathematical models represents state of the art method in development of new combustion technologies with increased efficiency and decreased environment impact. All mathematical models will be developed within the Euler Eulerian multiphase approach, which in combination with the detailed chemistry mechanisms for model the combustion process, defines new method for solving the multiphase reactive flows. Comparing to the commonly used methods, the new method will describe better the dense region processes which will result in reliable description of the combustion and emission formation processes. The newly developed method will allow research of real engineering combustion systems. The results from this project are intended for development of new technologies and specifically for reducing pollutant emission from industry and transport sector. Finally, research results will be available to Croatian economies and could be used for enhancing its competitiveness on the global market.]]></summary_en></project><project>
<id>4490</id><title_hr><![CDATA[INOVATIVNI FUNKCIONALNI PROIZVODI OD JANJEĆEG MESA]]></title_hr><title_en><![CDATA[INNOVATIVE FUNCTIONAL LAMB MEAT PRODUCTS]]></title_en><user_id>313</user_id><user_firstLast_name>Maja Popović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-3685</code><acronim><![CDATA[INOJANJETINA]]></acronim><duration>01.03.2018 - 28.09.2023</duration><status>Završio</status><financ_value>113.249,32 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Veterinarska medicina, Javno zdravstvo i zdravstvena zaštita, </scie_field_hr><scie_field_en>Veterinary medicine, Public health and health services, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Veterinarski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Veterinary Medicine]]></institution_en><team_members_id>17525, 17314, 5662, 17577, 17508, 19485, 19874, 5510, 17509, 17472, 17605, 20163, 17484, 19396, 28633, 26966, 11258, </team_members_id><team_members_names><![CDATA[Miljenko Šimpraga, Ana Shek Vugrovečki, Daniel Špoljarić, Bela  Njari, Željka Cvrtila, Ivona Žura Žaja, Matko Kardum, Gordan Mršić, Lidija Kozačinski, Suzana Milinković Tur, Tomislav Mikuš, Ksenija Vlahović, Nina Poljičak Milas, Branimira Špoljarić, Luka Pajurin, Goran Kiš, Silvijo Vince, ]]></team_members_names><keywords_hr><![CDATA[plemenita pečurka, janje, nutritivna modulacija, funkcionalni proizvod, tehnologija mesa]]></keywords_hr><keywords_en><![CDATA[white button muschroom, lamb, nutrition modulation, functional produc, meat technologyi]]></keywords_en><summary_hr><![CDATA[Janjeće meso se odlikuje vrlo plemenitim okusom i mirisom te se navodi kao izvor biološki vrijednih proteina, vitamina B kompleksa i nekih minerala, lako je probavljivo te je izvanrednih dijetetskih osobina no meso ima relativno visok udio masti (7,8 g/100 g krtog mesa) i kolesterola (78 mg/100g krtog mesa).U ovom projektu naše prethodno znanstveno dokazane preporuke o sigurnom i djelotvornom uvođenju pripravka plemenite pečurke (PPP) u hranu za perad i svinje ispitati ćemo na modelu janjeta (što do sada nije poznato), te pri tome istovremeno predstaviti mogući tržišno novi proizvod (janjetine s nižim udjelima masti i kolesterola). U dosadašnjim istraživanjima zapazili smo snižavanje koncentracije kolesterola i glukoze u serumu ispitivanih ovaca hranjenih uz dodatak PPP no da li je isti učinak i na meso nije poznato. S obzirom na navedeno, cilj je ovoga projekta ocijeniti utjecaj dodatka PPP na kvalitetu mesa janjadi koje bi onda bilo pogodno kao sirovina za  proizvodnju funkcionalnih proizvoda koji se temelje na inovativnim rješenjima u tehnološkim postupcima proizvodnje.]]></summary_hr><summary_en><![CDATA[Lamb meat is characterized by a very noble taste and smell, and is cited as a source of biologically valuable proteins, vitamins of B complex and some minerals, easily digestible and with exceptional nutritional qualities. but the meat has a relatively high fat content (7.8 g/100 g lean meat) and cholesterol (78 mg/100g of lean meat). In this project our previous recommendations on scientifically proven safe and effective introduction of white button mushrooms (WBM) preparation in feed for poultry and pigs will be tested on the lamb model (which was not known until now). At the same time a possible new product on a market - lamb with lower fat and cholesterol levels, would be presented. That is because we have in our previous studies observed a reduction in plasma cholesterol and glucose levels of tested sheep fed with the addition of WBM preparation but whether the same effect is in the meat is not known. That being said, the goal of this project is to evaluate the influence of WHB feed supplementation on lambs meat quality which would then be suitable as a material for production of functional products based on innovative solutions in technological processes of production.]]></summary_en></project><project>
<id>4494</id><title_hr><![CDATA[Hrvatska znanstvena i filozofska baština: transferi i aproprijacije znanja od srednjeg vijeka do dvadesetog stoljeća u europskom kontekstu]]></title_hr><title_en><![CDATA[Croatian Scientific and Philosophical Heritage: Transfers and Appropriations of Knowledge from the Middle Ages to the Twentieth Century in the European Context]]></title_en><user_id>19067</user_id><user_firstLast_name>Željko Dugac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-6762</code><acronim><![CDATA[HZIFBTIAZOSVDDSUEK]]></acronim><duration>20.03.2017 - 19.03.2021</duration><status>Završio</status><financ_value>77.500,92 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Povijest, Filozofija, </scie_field_hr><scie_field_en>History, Philosophy, </scie_field_en><institution_hr><![CDATA[Hrvatska akademija znanosti i umjetnosti]]></institution_hr><institution_en><![CDATA[Croatian Academy of Sciences and Arts]]></institution_en><team_members_id>20139, 20134, 19046, 1535, 268, </team_members_id><team_members_names><![CDATA[Marijana Borić, Bojan Marotti, Vedran Duančić, Branka Grbavac, Zrinka Blažević, ]]></team_members_names><keywords_hr><![CDATA[povijest znanosti, filozofija znanosti, transferi i aproprijacije znanstvenog znanja, srednji vijek, rani novi vijek, dvadeseto stoljeće]]></keywords_hr><keywords_en><![CDATA[history of science, philosophy of science, transfers and appropriations of scientific knowledge, middle ages, early modern period, twentieth century]]></keywords_en><summary_hr><![CDATA[Cilj istraživanja je kritički analizirati nove i neobjavljene izvore te ponuditi novi pogled na neke od najbitnijih i najutjecajnijih primjera transfera i aproprijacija znanstvenog znanja na hrvatskom prostoru od srednjega vijeka u širem međunarodnom i transnacionalnom kontekstu. Projekt istražuje aktivan proces aproprijacije od strane hrvatskih znanstvenika, njihov doprinos u različitim specifičnim lokalnim kontekstima, kao i na njihov doprinos globalnim znanstvenim procesima već prepoznatim u povijesti, filozofiji i sociologiji znanosti. Predloženi projekt istražuje specifične modalitete povijesnih transfera i aproprijacija znanstvenog znanja u kontekstu polu-perifernog položaja hrvatskih povijesnih teritorija, koji se očitovao u specifičnom položaju hrvatskih zemalja između mletačkih, osmanskih i habsburških imperijalnih sustava, kao i u liminalnom položaju tijekom Hladnog rata.]]></summary_hr><summary_en><![CDATA[The objective of the research is to critically analyze new and unpublished sources, and offer a new perspective on some of the most important and influential instances of transfers and appropriation of scientific knowledge in Croatia since the Middle Ages in a wider international and transnational context.  The research focuses on the active process of appropriation by scientists in/from Croatia, their contribution within a variety of specific local contexts as well as the impact in global processes recognized by history of philosophy and science. The proposed project examines the specific modalities of historical transfers and appropriations of scientific knowledge in connection to the Croatian semi-peripheral position, which was manifested in the position of Croatian lands between the Venetian, Ottoman, and Habsburg imperial systems and of an in-between position of Croatia and Yugoslavia for much of the Cold War.]]></summary_en></project><project>
<id>4495</id><title_hr><![CDATA[Transformacija rada u posttranzicijskoj Hrvatskoj]]></title_hr><title_en><![CDATA[Transformation of Work in Post-transitional Croatia]]></title_en><user_id>12526</user_id><user_firstLast_name>Reana Senjković-Svrčić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-7388</code><acronim><![CDATA[TRANSWORK]]></acronim><duration>01.04.2017 - 31.05.2021</duration><status>Završio</status><financ_value>63.756,06 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Etnologija i antropologija, </scie_field_hr><scie_field_en>Ethnology and anthropology, </scie_field_en><institution_hr><![CDATA[Institut za etnologiju i folkloristiku]]></institution_hr><institution_en><![CDATA[Institute of Ethnology and Folklore Research in Zagreb]]></institution_en><team_members_id>11205, 11288, 11210, 11211, 7812, 12631, 11206, 12897, 25145, </team_members_id><team_members_names><![CDATA[Tea Škokić, Ozren Biti, Orlanda Obad, Petar Bagarić, Ines Prica, Joško Ćaleta, Sanja Potkonjak, Mislav Žitko, Romana Pozniak, ]]></team_members_names><keywords_hr><![CDATA[transformacija, rad, posttanzicija, Hrvatska, etnografija rada]]></keywords_hr><keywords_en><![CDATA[transformation, work, post-transition, Croatia, ethnography of work]]></keywords_en><summary_hr><![CDATA[Na tragu kontinuiranog praćenja postsocijalističkih procesa predloženi projekt u hrvatsku etnologiju i kulturnu antropologiju uvodi subdisciplinu antropologije rada. Unutar interdisciplinarnog okvira oslonjenog na recentna postignuća europske antropologije, antropologije (post)socijalizma, antropologije rada, kritičkih studija rada, ekonomske antropologije itd., predložena konceptualna i neposredna etnografska istraživanja usredotočit će se na radnu svakodnevicu građana posttranzicijske Hrvatske. Istraživanja će pratiti dinamiku promjena i prilagodbi radne i životne ekonomije kroz efekte koji su u posttranzicijskoj Hrvatskoj dramatično promijenili iskustvo rada te će propitati nove kulturne imaginarije vezane uz ideju rada i projekciju budućnosti. Metodološki, projekt se temelji na empirijskim, etnografskim istraživanjima koja će se provesti na odabranim lokalitetima u Dalmaciji, Istri, Slavoniji, Baniji i u Zagrebu. Suradnici projekta TRANSWORK će, kvalitativnom metodom polustrukturiranih intervjua, razgovarati s informatorima o njihovim očekivanjima, ukoliko su zaposleni, o životu bez rada onih koji nisu zaposleni, o njihovom viđenju budućnosti, ali i o njihovim sjećanjima na rad i život kakav je nekad bio. Osim empirijskog dijela, projekt će se baviti i praćenjem koncepata i prakse rada u društvenopovijesnom kontinuitetu (od socijalističkog razdoblja do postsocijalističke periferije i krize neoliberalizma). Na osnovi arhivskih i teorijskih istraživanja, ali i izravnom metodom usmjerenih intervjua, ispitat će se koncepti, vrijednosti i praksa tradicionalnih modela rada koji sežu u socijalističko nasljeđe radničkog etosa te tranzicije industrijskog u aktualni, uslužni sektor djelatnosti.]]></summary_hr><summary_en><![CDATA[As part of the continual following of post-socialist processes the proposed project introduces to Croatian ethnology and cultural anthropology a sub-discipline of anthropology of work. Within the interdisciplinary framework based on the recent accomplishments of European anthropology, the anthropology of (post)socialism, anthropology of work, critical studies of work, economic anthropology etc., the proposed conceptual and ethnographic research will focus on the working everyday life of the citizens of post-transitional Croatia.The research will follow the dynamics of adjustment of the work and life economy in post-transitional Croatia through the effects that have dramatically changed the experience of work. It will examine new cultural imageries connected with the idea of work and projections for the future. The project will be based on empirical, ethnographic research method. Semi-structured interviews will be conducted at the selected locations in Dalmatia, Istria, Slavonia, Banija and in the town of Zagreb. The TRANSWORK team members will be interested in informants&#39; expectations, if they are employed, in their everyday life without work if they are unemployed, in their seeing of the future, but also in their memories of the life as it once was.In addition to the empirical part, project will be monitoring the concepts and work practices in social and historical continuity (spanning from the socialist period to the post-socialist periphery and the crisis of neo-liberalism). This includes archival and theoretical research, focused interviews of work models which derive from the socialist heritage of workers’ ethos, as well as professional and identity transitions into the industrial and service sector activities.]]></summary_en></project><project>
<id>4496</id><title_hr><![CDATA[Napredna monolitna i kompozitna keramika za zaštitu od trošenja i korozije]]></title_hr><title_en><![CDATA[Monolithic and composite advanced ceramics for wear and corrosion protection]]></title_en><user_id>900</user_id><user_firstLast_name>Lidija Ćurković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-6000</code><acronim><![CDATA[WECOR]]></acronim><duration>01.05.2017 - 30.11.2021</duration><status>Završio</status><financ_value>111.487,16 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, Kemijsko inženjerstvo, Temeljne tehničke znanosti, </scie_field_hr><scie_field_en>Mechnical engineering, Chemical engineering, Basic engineering sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>1160, 2537, 4538, 2798, 4064, 12690, 23213, 23212, 23211, </team_members_id><team_members_names><![CDATA[Krešimir Grilec, Danko Ćorić, Vera Rede, Darko Landek, Irena Žmak, Sanda Rončević, Milan Vukšić, Ivana Sever, Zrinka Švagelj, ]]></team_members_names><keywords_hr><![CDATA[napredna keramika, Al2O3, Al2O3-ZrO2, lijevanje suspenzije, trošenje, korozija]]></keywords_hr><keywords_en><![CDATA[advanced ceramics, Al2O3, Al2O3-ZrO2, slip casting, tribology, corrosion ]]></keywords_en><summary_hr><![CDATA[Istraživat će se suspenzije za oblikovanje napredne mikro/nanostrukturirane monolitne Al2O3 i kompozitne Al2O3-ZrO2 keramike postupkom lijevanja i optimirat će se parametri postupka oblikovanja i sinteriranja. Glavne su prednosti oblikovanja lijevanjem suspenzije niski troškovi procesa, ekološka prihvatljivost, jednostavnost i fleksibilnost, potencijal za jednoliko slaganje čestica te prikladnost za proizvodnju dijelova složenog oblika. Istražit će se i mogućnost dobivanja mikro/nanoporozne Al2O3 keramike, tako da se dio sirovine zamijeni otpadnim Al2O3 prahom koji nastaje strojnom obradom sirovca. Na taj način postići će se uštede na sirovinama uz istovremeno zbrinjavanje otpada, tj. zaštitu okoliša.Provest će se: (i) istraživanje reoloških svojstava u ovisnosti o sastavu suspenzije, (ii) istraživanje utjecaja omjera Al2O3-ZrO2, veličina njihovih čestica, utjecaj vrste i količine aditiva na reološka svojstva suspenzija, kao i na mikrostrukturu, mehanička, tribološka i korozijska svojstva konvencionalno i mikrovalno (nekonvencionalno) sinterirane napredne monolitne i kompozitne keramike te (iii) utvrđivanje funkcionalne ovisnosti sastava i svojstava napredne keramike na bazi Al2O3 kao matrice, uz dodatak ZrO2 nanočestica.Matematičko modeliranje koristit će se za utvrđivanje utjecaja sastava, procesnih parametara i postignute strukture na mehanička, tribološka i korozijska svojstva napredne monolitne i kompozitne keramike.Očekivani rezultati: (i) razumijevanje i prikupljanje znanja o postupcima priprave suspenzije te doprinosa pojedinih komponenata suspenzije na svojstva keramičkog materijala, (ii) optimiranje suspenzija za lijevanje mikro/nanostrukturirane monolitne i kompozitne keramike (iii) razvoj napredne kemijski postojane kompozitne Al2O3-ZrO2 keramike s poboljšanom kombinacijom mehaničkih svojstava i otpornosti na trošenje u usporedbi s monolitnom Al2O3 keramikom te (iv) razvoj mikro/nanoporozne Al2O3 keramike oporabom industrijskog otpada.]]></summary_hr><summary_en><![CDATA[Suspensions for the slip casting of micro/nanostructured monolithic Al2O3 and composite Al2O3-ZrO2 advanced ceramics will be investigated, and slip casting and sintering parameters will be optimized. Main advantages of slip casting process are low costs, environmentally friendly process, simplicity and flexibility, potential for uniform particle packing and suitability for the production of parts of intricate shape. The possibility of production of the micro/nanoporous alumina by the replacement of a part of the raw material with the alumina waste obtained by green machining will be investigated. This will result in reducing raw materials costs and enhance waste management, i.e. environmental protection.The research will involve (i) study of rheological properties, depending on the suspension composition, (ii) study of the influence of Al2O3-ZrO2 ratio, particle size and type, and the amount of additives on the slip rheological properties as well as on microstructure, mechanical, tribological and corrosion properties of conventionally and microwave sintered advanced ceramics, and (iii) estimation of composition–property functional relationships of ceramics based on alumina matrix with the addition of nanosized zirconia.Mathematical modelling will be used for the determination of influence of composition, processing parameters and resulting structure on mechanical, tribological and corrosion properties of advanced ceramics.Expected outcomes: (i) understanding and gathering the know-how on the suspension preparation procedures, and the contribution of different components on the bulk properties of sintered samples, (ii) optimization of suspensions for slip casting of micro/nanostructured advanced ceramics, (iii) development of chemical resistant composite ceramics with an improved combination of mechanical properties and wear resistance compared to the alumina ceramics, (iv) development of the micro/nanoporous Al2O3 ceramics from industrial waste.]]></summary_en></project><project>
<id>4501</id><title_hr><![CDATA[Priobalna rastilišta: obrasci i procesi demografske varijabilnosti morskih riba uzduž istočnojadranske obale]]></title_hr><title_en><![CDATA[Coastal nursery habitats: Patterns and processes of demographic variability in marine fish species along the eastern Adriatic coast ]]></title_en><user_id>2707</user_id><user_firstLast_name>SANJA MATIĆ-SKOKO</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-9884</code><acronim><![CDATA[NurseFish]]></acronim><duration>15.03.2017 - 14.08.2021</duration><status>Završio</status><financ_value>117.194,24 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut za oceanografiju i ribarstvo]]></institution_hr><institution_en><![CDATA[Institute of Oceanography and Fisheries]]></institution_en><team_members_id>1215, 4026, 4583, 4946, 3958, 5215, 124, 20129, 667, 19894, 27428, </team_members_id><team_members_names><![CDATA[Jakov Dulčić, Armin Pallaoro, Pero Tutman, Branko Dragičević, Dubravka Bojanić Varezić, Krešimir Markulin, Branko Glamuzina, Marcelo Kovačić, Melita Peharda Uljević, Dario Vrdoljak, Mišo Pavičić, ]]></team_members_names><keywords_hr><![CDATA[rastilište, nedorasle ribe, selidba, novačenje, otolit, geokemija, obala, estuarij]]></keywords_hr><keywords_en><![CDATA[nursery grounds, juvenile fish, settlement, recruitment, otolith, geochemistry, coast, estuary]]></keywords_en><summary_hr><![CDATA[Nažalost, mnoga priobalna staništa su pod povećanim okolišnim i antropogenim pritiscima i postoji  nedostatak saznanja o uzročno-posljedičnim odnosima tih pritisaka na morski ekosustav. Međutim, utvrđivanje takvih odnosa između širokog raspona stresnih čimbenika i njihovih učinaka na razini jedinke, vrste ili zajednice u morskom ekosustavu, je vrlo težak zadatak.Estuariji i priobalna područja se uobičajeno smatraju za visoko produktivne i vrijedne ekosustave. Istaknuta je njjihova uloga kao rastilišta za rane razvojne stadije mnogih vrsta. No, postoje  nejasni dokaz o važnosti obilježja staništa u u oblikovanju obrazaca dinamike populacija riba. Stoga, glavni istraživački ciljevi ovog projekta su šira prostorna procjena rastilišta riba uzduž obale srednjeg Jadrana, prostorno-vremenski trendovi u strukturi nedoraslih ribljih zajednica u rastilištima s međugodišnjom varijabilnosti u gustoći nedoraslih i jačine godišnje klase za određene gospodarski važne vrste riba; povezanost između estuarijskih i prioobalnih staništa preko elementarnih geokemijskih otisaka otolita  koji ukazuju na gibanja riba i vremensku konzistenciju individualnog doprinosa svakog pojedinog rastilišta obalnim područjima/populacijama riba. Također, analizirat će se vremenske promjene u strukturi nedoraslih ribljih zajednica unutar dva desetljeća s osnovnim matricama raznolikosti koje karakteriziraju promjene u taksonomskom sastavu zajednice kroz vrijeme, utvrđivanje da li je došlo do povećanja termofilnih vrsta i eventualno veća učestalost pelagičnih vrsta kako bi se osigurali dokazi za moguće faunističke promjene.Istraživanja u okviru predloženog projekta provodit će se duž istočne obale srednjeg Jadrana primjenom suvremenih metoda terenskog rada i analize. Projektni tim će izgraditi nove istraživačke kapacitete, a rezultati projekta u potpunosti će biti primjenjivi u upravljanju priobalnim ribarstvom na osnovu ekoloških principa i očuvanju biološke raznolikosti u Jadranu.]]></summary_hr><summary_en><![CDATA[Unfortunately, many of coastal habitats are under increasing environmental and anthropogenic pressures and there is a lack of data on causal relationships of these pressures on the marine ecosystems. However, establishing causal relationships between a wide range of stressors and effects at the individual, species or community level on marine ecosystems, is a difficult task.Estuaries and coastal areas are commonly acknowledged as highly productive and valuable ecosystems. Their role as nurseries for early life stages of many species has been highlighted. There is ambiguous evidence regarding the importance of habitat characteristics in driving patterns of fish population dynamics. Thus, the main research goals of this project are large-scale assessment of fish nursery grounds along the middle Adriatic coast, spatio-temporal trends in the structure of juvenile fish communities in nurseries with inter-annual variability in juvenile densities and year-class strength for certain economically important species; connectivity between estuarine and coastal habitats: through otolith elemental fingerprints unraveling fish movement and temporal consistence of individual nursery contributions to coastal areas. Also, temporal changes in juvenile fish assemblages structure over two decades with baseline of diversity metrics characterizing the change in taxonomic community composition through time, determining whether there has been an increase in warm-water affinity species and eventual higher incidence of pelagic species will be analyzed attempting to provide evidence for faunal changes. Research in the framework of the proposed project will be conducted along the middle eastern Adriatic coast applying modern fieldwork and analysis methods. The project team will build new research capacities while the results of the project are fully applicable for implementation in the ecology-based management of coastal fisheries and biodiversity conservation in the Adriatic Sea.]]></summary_en></project><project>
<id>4506</id><title_hr><![CDATA[Epigenetički biomarkeri u krvi i ejakulatu bolesnika sa seminomom testisa]]></title_hr><title_en><![CDATA[Epigenetic biomarkers in the blood and ejaculate of patients with testicular seminoma]]></title_en><user_id>3016</user_id><user_firstLast_name>Davor  Ježek</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-3692</code><acronim><![CDATA[epiSem]]></acronim><duration>01.08.2017 - 01.11.2021</duration><status>Završio</status><financ_value>129.802,91 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Kliničke medicinske znanosti, Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Clinical sciences, Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>1440, 3977, 3053, 3326, 19170, 13773, 20090, 19914, 3990, 4700, 19946, 641, 19217, 640, 19906, 2813, 4155, 19967, 4603, 7205, </team_members_id><team_members_names><![CDATA[Floriana Jakuš, Maja Vlahović, Ana Katušić Bojanac, Nino Sinčić, Jure Krasić, Jerka Dumić, Boris Ružić, Igor Tomašković, Tvrtko  Hudolin, Marija Gamulin, Miroslav  Tomić, Dinka Pavičić Baldani, Dejan Ljiljak, Lana Škrgatić, Nina Gelo, Davor Tomas, Marijana Ćorić, Monika Ulamec, Milan Milošević, Antonio Juretić, ]]></team_members_names><keywords_hr><![CDATA[tumori testisa, seminom, biomarkeri, epigenetika, slobodna DNA, metilacija DNA, varijacija broja kopija gena]]></keywords_hr><keywords_en><![CDATA[testicular tumors, seminoma, biomarkers, epigenetics, cell-free DNA, DNA methylation, gene copy number variation]]></keywords_en><summary_hr><![CDATA[Tumori zametnih stanica testisa (TGCT) najčešći su tumori mlađe muške populacije u svijetu. Naša epidemiološka studija iz 2011., pokazala je najviši trend porasta stope incidencije u svijetu te visok mortalitet u hrvatskoj populaciji. „Model-based“ istraživanja trendova rizika i demografskih kretanja iz 2014. ističu hrvatsku populaciju kao jednu od tri najugroženije u Europi te predviđaju da će u RH do 2025. jednom od 100 muškaraca godišnje biti dijagnosticiran TGCT. Upravo je seminom najčešći tip TGCTa, s trendom daljnjeg porasta. Smatra se da i (mikro)okolišni i (epi)genetski čimbenici dovode do njegova razvoja. Danas se epimutacije metilacije DNA kao tumorski biomarkeri ističu zbog svoje visoke frekvencije te izrazite kemijske i biološke stabilnosti, što im daje prednost u razvoju neinvazivne dijagnostike. Upravo se istraživanja biomarkera iz tjelesnih tekućina danas snažno potiču budući se taj koncept smatra jednim od temelja personalizirane medicine. Hipoteza je predloženog prospektivnog istraživanja da se u krvnoj plazmi i ejakulatu mogu identificirati biomarkeri seminoma na razini metilacije slobodne DNA. Usporedno s anamnestičkom i kliničkom obradom, sveobuhvatno istraživanje metilacije DNA provesti će se na uzorcima bolesnika prije i poslije terapijskog zahvata te rezultati usporediti s uzorcima zdravih muškaraca. Usporedba rezultata metiliranosti slobodne DNA i DNA tumora, kao i varijacije broja kopija gena, razjasnit će udio tumorske DNA u tjelesnim tekućinama, otkloniti pozadinski šum slobodne DNA zdravog tkiva te pokazati utjecaj genomskih aberacija na informativnost analize metilacije slobodne DNA. Usporedba ovih rezultata s proteinskom ekspresijom ispitivanih gena u seminomima u uzorcima istih bolesnika, razjasnit će odnos metoda suvremene molekularne patologije i predloženih novih pristupa u okviru razvoja personalizirane medicine. Očekuje se znanstveni doprinos u području razvoja epigenetičkih biomarkera u tjelesnim tekućinama onkoloških bolesnika.]]></summary_hr><summary_en><![CDATA[Testicular germ cell tumors (TGCTs) are the most common tumors of young male population worldwide. Our epidemiological study from 2011 showed Croatian population to have an increasing incidence trend which seems to be the steepest in the world, along with high mortality as well.  &#39;&#39;Model-based&#39;&#39; research of risks and demographic trends from 2014 highlights Croatian population as one of three most vulnerable in Europe, predicting that one of 100 Croatian men will be diagnosed with TGCT annually by 2025. The most frequent type of TGCT is seminoma, with further rising trend. It is believed that (micro)environmental and (epi)genetic factors lead to its development. DNA methylation epimutations as tumor biomarkers assert themselves because of their high frequency and extreme chemical and biological stability, giving them advantage in non-invasive diagnostics. Research of biomarkers from body fluids is strongly encouraged since it represents one of the basic elements of personalized medicine development. The hypothesis of proposed prospective study is that in the blood and ejaculate, seminoma specific biomarkers at the level of cell-free DNA methylation may be identified. Based on anamnestic and clinical data, comprehensive study of DNA methylation will be carried out in healthy men as well as patients, before and after therapeutic management. The study of cfDNA and DNA methylation in tumors, in addition to gene copy number variations, will clarify the proportion of tumor DNA in bodily fluids and show the impact of genomic aberrations in the analysis of cfDNA methylation. Comparison of these results with protein expression of tested genes in seminoma samples of same patients will clarify whether contemporary molecular pathology methods could be supplemented by the proposed new approach on the path of personalized medicine development. This study is expected to significantly contribute to the development of epigenetic biomarkers in body fluids of cancer patients.]]></summary_en></project><project>
<id>4511</id><title_hr><![CDATA[Procjena atmosverskog taloženja i razine ozona u mediteranskim šumskim ekosustavima]]></title_hr><title_en><![CDATA[Assessment of Atmospheric Deposition and Ozone levels in Mediterranean Forest ecosystems ]]></title_en><user_id>6636</user_id><user_firstLast_name>Tamara Jakovljević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-3337</code><acronim><![CDATA[DepOMedFor]]></acronim><duration>01.03.2017 - 29.02.2020</duration><status>Završio</status><financ_value>78.439,18 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Šumarstvo, </scie_field_hr><scie_field_en>Forestry, </scie_field_en><institution_hr><![CDATA[Hrvatski šumarski institut]]></institution_hr><institution_en><![CDATA[Croatian Forest Research Institute]]></institution_en><team_members_id>848, 849, 6352, 3501, 3507, 19671, 12438, 13364, 12446, 20028, 25412, 25878, </team_members_id><team_members_names><![CDATA[Nenad Potočić, Ivan Seletković, Krunoslav Indir, Lukrecija Butorac, Goran  Jelić, Renato Buljan, Željko Zgrablić, Aldo Marchetto, Alessandra De Marco, Guillaume Simioni, Lucija Lovreškov, Ivan Limić, ]]></team_members_names><keywords_hr><![CDATA[atmosfersko taloženje, ozon, mediteranski šumski ekosustav, procjena, praćenje]]></keywords_hr><keywords_en><![CDATA[atmospheric deposition, ozone, mediterranean forest ecosystems, assessment, monitoring]]></keywords_en><summary_hr><![CDATA[Šumski ekosustavi se odlikuju izrazito promijenjivim uvjetima za rast i razvoja. Mediteranska regija čini se da je najosjetljivija na globalne promjene i atmosferske utjecaje. Mediteranski šumski ekosustavi su od velike važnosti zbog ekoloških funkcija koje pružaju. Rizik od utjecaja atmosferskih taloženja, erozija, klizišta i poplava je tako visok. Ovi faktori rizika u kombinaciji s klimatskim promjenama  vjerojatno utječu na ciklus nutrienta i hranidbe vrijednosti, vlažnost tla i, u konačnici, na rast i primarnu produktivnosti. Predloženo istraživanje će dati jedinstvenu mogućnost za analizu ne samo biogeokemijskim ciklus elemenata, na lokalnoj razini, nego i procjenu utjecaja onečišćenja na dijelove šumskog ekosusstava, te tijek od izvora do receptora. Da bi ostvarili ciljeve projekta uspostavit će se plohe za praćenje atmosferskih taloženje i razine ozonski na kojima će se vršti mjerenja mjeriti zajedno drugim varijablama, uključujući one koji se odnose na tlo i lišće te hranjiva, zdravstveni satus stabla, rast i stanje krošnje u kombinaciji s meteorološkim podacima. Mi ćemo dobiti potpuno nove, ali potrebne informacije koje nedostaju o atmosferskom taloženju, statusu hranjivih tvari, stvarnim opterećenjima, razini ozona i njegovih učinaka na šumama. Dodane vrijednosti ovog istraživanja će biti ispunjavanja praznina u znanju o naših mediteranskim šumskim ekosustavima i nadogradnju stečenog znanja s različitim statističkim metodama i budućih predviđanja kako bi se procijenilo stanje mediteranskih šumskih ekosustava. Rezultata ovog istraživanja i suradnje s talijanskim i francuski znanstvenim institucijama doprinijeti će široj osvrtu na utjecaje atmosferilija na mediteranske šumske ekosustave istočne obale Jadrana na regionalnoj i Europskoj razini.]]></summary_hr><summary_en><![CDATA[Forest ecosystems are characterized by strongly ?uctuating conditions for tree growth and development. The Mediterranean region appears to be the most vulnerable to global change and atmospheric inputs. Mediterranean forest ecosystems are of very high significance because of ecological functions they provide. The risk of impacts of atmospheric inputs, erosion, landslides and floods is being so high in this region. These risk factors combined with climate change is likely to affect nutrient turnover and nutrient availability, soil moisture and, ultimately, growth and primary productivity. The proposed research will give the unique possibility to analyse not only the biogeochemical cycle of elements, at local scale, but also the assessment of the environmental impact of pollutants on forest ecosystems compartments, following the uptake and the fate, from the sources to the receptors. In order to accomplish project objectives the monitoring plots will be established and atmospheric deposition and ozone levels will be measured together with a suite of other variables including those related to soil and foliar nutrient, tree health, growth and crown condition combined with meteorological data. We will get completely new but necessary missing information on atmospheric deposition, nutrient status, actual loads and ozone levels and its effects on forests. The added values of this research will be filling the gap in knowledge of our Mediterranean forest ecosystems and upgrading the gained knowledge with different statistical methods and future predictions in order to assess the condition of Mediterranean forest ecosystems.The results of this research and collaboration with Italian and French scientific institutions will contribute to the wider overview on impacts of atmospheric inputs in Mediterranean forests ecosystem of Eastern Adriatic coast at the regional and European level.]]></summary_en></project><project>
<id>4515</id><title_hr><![CDATA[BILJKE KAO IZVOR BIOAKTIVNIH SUMPOROVIH SPOJEVA TE NJIHOVA SPOSOBNOST HIPERAKUMULACIJE METALA]]></title_hr><title_en><![CDATA[PLANTS AS A SOURCE OF BIOACTIVE SULPHUR COMPOUNDS AND THEIR ABILITY TO HYPERACCUMULATE METALS]]></title_en><user_id>90</user_id><user_firstLast_name>Ivica Blažević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-1316</code><acronim><![CDATA[BioSMe]]></acronim><duration>01.03.2017 - 31.08.2021</duration><status>Završio</status><financ_value>118.322,38 eur</financ_value><scie_area_hr>Prirodne znanosti, Biotehničke znanosti, Tehničke znanosti, </scie_area_hr><scie_area_en>Natural sciences, Biotechnical sciences, Technological sciences, </scie_area_en><scie_field_hr>Kemija, Kemijsko inženjerstvo, Biotehnologija, Prehrambena tehnologija, Nutricionizam, </scie_field_hr><scie_field_en>Chemistry, Chemical engineering, Biotechnology, Food technology, Nutrition, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Kemijsko-tehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Chemistry and Technology]]></institution_en><team_members_id>403, 3364, 250, 13382, 19118, 19145, 19228, 19975, 5082, 3954, 122, 89, 25207, 23035, 5669, 100, </team_members_id><team_members_names><![CDATA[Tea  Bilušić, Sandra Svilović, Ivana Generalić Mekinić, Maša Buljac, Lea Kukoč Modun, Mario Nikola Mužek, Maja Biočić, Azra Đulović, Mirko Ruščić, Ivica Ljubenkov, Vedrana Čikeš Čulić, Joško Markić, Ivana Vrca, Marijana Popović, Nada  Bezić, Franko Burčul, ]]></team_members_names><keywords_hr><![CDATA[bioaktivni sumporovi spojevi, antioksidacijsko djelovanje, antitumorsko djelovanje, antimikrobno djelovanje, hiperakumulacija metala]]></keywords_hr><keywords_en><![CDATA[bioactive sulphur compounds, antioxidative activity, anticancer activity, antimicrobial activity, metal hyperaccumulation]]></keywords_en><summary_hr><![CDATA[Gotovo četvrtina svih farmaceutskih proizvoda u svijetu se dobiva iz biljaka. Biljni metaboliti sa sumporom uključuju raznolike kemijske strukture koji upravo zbog prisutnosti sumpora pokazuju određene fizikalno-kemijske značajke i međudjelovanja s različitim molekulskim i biološkim metama.Botanički red Brassicales, u koji ubrajamo brojne svakodnevno korištene vrste povrća (kupus, brokula, kapare itd.), je izrazito kemokarakteriziran prisutnošću tiosaharidnih sekundarnih metabolita-glukozinolata (GLa). GLi su spojevi koji se neprekidno istražuju, otkrivaju se i nove strukture pa danas ta grupa fitokemikalija broji oko 130 spojeva. Projekt će se usredotočiti na slabo ili prethodno neistražene samonikle vrste (endemske i dr.) iz reda Brassicales. GLi, koji su povezani s atipičnom endogenom glukohidrolazom-mirozinazom (E.C.3.2.1.147), djeluju kao bioprekursori biološki aktivnim izotiocijanatima te im je, u posljednjih 20 godina, posvećena posebna pozornost zbog korisnih učinaka na zdravlje. Specifični ciljevi ovog projekta uključuju njihovu izolaciju i biološka ispitivanja. Korisni biološki učinci biljaka koje sadrže sumporove derivate očituju se njihovom svakodnevnom upotrebom u prehrani. Kako bi spoj pokazao aktivnost in vivo, mora biti stabilan i biodostupan te će se isti istražiti u uvjetima simuliranog dvofaznog probavnog procesa korištenjem ljudskih probavnih enzima (želučani i crijevni). Istraživanje novih GLa i drugih biljaka koje sadrže biološki aktivne sumporove spojeve može potaknuti razvoj novih hortikulturalnih usjeva. Do danas je poznat veliki broj biljnih vrsta iz porodice Brassicaceae koje posjeduju sposobnost hiperakumulacije metala. Mnogi metali, ne samo da se hiperakumuliraju, već spadaju u esencijalne nutrijente pa se obogaćivanje hrane mikronutrijentima i fitoremedijacija mogu promatrati kao dvije strane istog novčića. Određivanje sposobnosti akumuliranja metala predstavlja jedan od bitnih aspekata uporabe ovih biljaka.]]></summary_hr><summary_en><![CDATA[Nearly quarter of all pharmaceutical products worldwide are derived from plant sources. Sulphur-containing plant metabolites include a variety of chemical structures which due to the presence of sulphur show particular physicochemical features and interact with a range of molecular and biological targets.The botanical order of the Brassicales-which encompasses many of our daily vegetables (cabbage, broccoli, capper etc.) is strikingly chemocharacterized by the presence of thiosaccharidic secondary metabolites-glucosinolates (GLs). GL investigation is an ongoing research activity and new structures have been documented, now including ca. 130 compounds. This project will focus on scarcely or previously not investigated wild-growing species (endemic and other) from the botanical order Brassicales.Associated with an uncommon endogenous glucohydrolase-myrosinase (E.C.3.2.1.147) GLs operate like precursors to biologically active isothiocyanates. Over the last 20 years these compounds have gained growing attention owing to their health-promoting properties. Specific focus of the project will involve their isolation and biological testing.The beneficial effects have been attributed to dietary consumption of sulphur containing vegetables. In order for any compound to exert an activity in vivo it is necessary to show stability and bioaccessibility. Thus they will be investigated under conditions of simulated two-step digestion process using human digestive enzymes (gastric and duodenal). Investigating novel GLs and other biologicaly active sulphur-containing plants may stimulate the development of new horticultural crops.As on to date many plants of Brassicaceae family are known to hyperaccumulate metals. As many of the metals that can be hyperaccumulated are also essential nutrients, food fortification and phytoremediation might be considered two sides of the same coin. Thus, analyzing plant capacity to accumulate metals represents one of the crucial aspects of plant usage.]]></summary_en></project><project>
<id>4518</id><title_hr><![CDATA[Epidemiologija hipertenzije i unos kuhinjske soli u Hrvatskoj ]]></title_hr><title_en><![CDATA[Epidemiology of hypertension and salt intake in Croatia]]></title_en><user_id>5508</user_id><user_firstLast_name>Bojan Jelaković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-9033</code><acronim><![CDATA[EH-UH 2]]></acronim><duration>01.09.2017 - 31.08.2020</duration><status>Prekinut</status><financ_value>99.542,11 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Javno zdravstvo i zdravstvena zaštita, Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Public health and health services, Clinical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>19655, 6539, 19729, 19621, 4373, 11291, 19610, 6805, 13257, 19640, 19825, 19632, 20029, 19681, 20221, 12396, 25935, </team_members_id><team_members_names><![CDATA[Ana Vrdoljak, Vanja Vasiljev Marchesi, Hrvoje  Tiljak, Ranko Stevanović, Jadranka  Sertić, Ivan Pećin, Sandra Karanovic, Aleksandar Džakula, Livija Šimičević, Lovorka Bilajac, Ivana Vukovic Brinar, Mirjana Fuček, Marion Tomičić, Danijela Štimac Grbić, Ines Balint, Živka Dika, Mihaela Marinović Glavić, ]]></team_members_names><keywords_hr><![CDATA[hipertenzija, kuhinjska sol, epidemiologija, prevalencija, svjesnost, liječenje, kontrola]]></keywords_hr><keywords_en><![CDATA[hypertension, salt intake, epidemiology, prevalence, awareness, treatment, control]]></keywords_en><summary_hr><![CDATA[Arterijska hipertenzija (AH) je vodeći uzrok pobola i smrti u svijetu pa tako i u Hrvatskoj.Prema podacima nacionalne EH-UH studije koja je završena prije 10 godina prevalencija je 37%, uz vrlo lošu kontrolu od oko 20%. Jedan od glavnih razloga velike prevalencije  i loše kontrole je prekomjeran unos kuhinjske soli koji prema rezultatima našeg istraživanja u Hrvatskoj iznosi preko 11 grama dnevno.Ti podaci su bili temelj za Strateški plan vlade Republike Hrvatske za smanjivanje prekomjernog unosa kuhinjske soli.Ciljevi ovoga projekta su:1)na temelju podataka iz arhive EH-UH 1 studije pozvati na kontrolni pregled sve ispitanike, pratiti klinički tijek i ishod ovisno o ulaznim pokazateljima;2)na način kako je rađeno u EH-UH 1 u EH-UH 2 skupini randomizirati novi uzorak opće populacije u cijeloj Hrvatskoj,koristiti isti upitnik,preglede,mjerenja arterijskoga tlaka i određivanja pridruženih čimbenika rizika te odrediti prevalenciju, svjesnost, liječenje i kontrolu hipertoničara, te odrediti dinamiku kretanja u Hrvatskoj tijekom perioda od 10 godina;3)u obje skupine (EH-UH1 i EH-UH2) odrediti unos kuhinjske soli mjerenjem 24-satne natriurije (zlatni standard za dnevnu procjenu unosa kuhinjske soli);4)u istom uzorku urina odrediti količinu joda kako bismo dobili podatak o sigurnosti smanjivanja unosa kuhinjske soli.Rezultati ovoga projekta omogućit će određivanje koji čimbenici najznačajnije utječu na progresiju AH i povezani su s fatalnim i nefatalnim ishodima;dobit ćemo podatak o dinamici kretanja prevalencije i kontroli AH u Hrvatskoj. Napose dobit ćemo podatak o kretanju unosa kuhinjske soli i povezanosti s AT, te o unosu joda. Dobiveni podaci koristit će kod planiranje strategija s ciljem podizanja kontrole AH i posljedično smanjivanja kardiovaskularnog, cerebrovaskularnog i renalnog rizika, a bit će važni i na međunarodnom planu u pregovorima Europskog društva za hipertenziju s Europskom komisijom.]]></summary_hr><summary_en><![CDATA[Hypertension (HT) is leading cause of morbidity and mortality worldwide and in Croatia. According to results from nationwide EH-UH study done 10 years ago, prevalence was 37%, with very poor control rate (20%). One of the major causes of high prevalence and poor control rate is excessive intake of salt. One of our study showed that the daily intake of salt in Croatia is around 11 grams. Data from that study were ground stone for Strategic Plan of the Government of Republic of Croatia for reducing excessive salt intake. Aims of this project are: 1) based on the archive of EH-UH 1 study do the follow-up of all the participants, to assess clinical course and outcome regarding entry data; 2) in EH-UH 2, following same methodology from EH-UH 1, to enroll new random sample of general population of entire Nation, use same questionnaire, means of physical exam and blood pressure measurements; to determine associated risk factors and to obtained prevalence, awareness, treatment and control rate of HT and to define the trend in Croatia in last 10 years; 3) salt intake will be assessed by measuring 24-hour natriuresis in both samples (EH-UH 1 and EH-UH 2), procedure considered to be the gold standard for daily table salt intake; 4) intake of iodine will be assessed from the same urine sample in order to avert suspicions that lowering salt intake will lead to  hypoiodinemia. Results from this research will help to define the factors with strongest impact on HT progression and are related with fatal and nonfatal events; data about prevalence and control rate of HT in Croatia will be obtained. Particularly, data on table salt intake and its impact on HT will be retrieve, along with iodine intake levels. Given data will be of use for planning further strategies for increasing HT control, and by that mean lowering overall cardiovascular cerebrovascular and renal risk. Also, data will suffice for European society of hypertension in its negotiations with European commission]]></summary_en></project><project>
<id>4524</id><title_hr><![CDATA[Optimizacijski i statistički modeli i metode prepoznavanja svojstava skupova podataka izmjerenih s pogreškama]]></title_hr><title_en><![CDATA[The optimization and statistical models and methods in recognizing properties of data sets measured with errors]]></title_en><user_id>895</user_id><user_firstLast_name>Rudolf Scitovski</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-6545</code><acronim><![CDATA[OSMoMeSIP]]></acronim><duration>01.03.2017 - 28.02.2021</duration><status>Završio</status><financ_value>80.230,94 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Fakultet primijenjene matematike i informatike]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, School of Applied Mathematics and Informatics]]></institution_en><team_members_id>921, 3831, 2970, 6124, 19959, 3045, 19617, </team_members_id><team_members_names><![CDATA[Mirta Benšić, Kristian Sabo, Emmanuel Karlo  Nyarko, Petar Taler, Andrew Barron Barron, Dragan  Jukić, Safet Hamedović, ]]></team_members_names><keywords_hr><![CDATA[Optimizacija, Analiza velikih podataka, Grupiranje podataka, Dekonvolucija, Statistički modeli]]></keywords_hr><keywords_en><![CDATA[Optimization, Big data analysis, Data Clustering, Deconvolution, Statistical Models]]></keywords_en><summary_hr><![CDATA[U okviru projekta razmatraju se optimizacijski i statistički aspekti  prepoznavanja svojstava skupova podataka izmjerenih s pogreškama kao sastavni dio atraktivnog i aktivnog područja istraživanja poznatog kao analiza velikih podataka (engl. Big data analysis).  Istraživanja će biti usmjerena na  probleme grupiranja podataka te dekonvolucijske modele i primjene.  Polazi se od pretpostavke da  promatrani skupovi podataka  predstavljaju mjerene vrijednosti varijabli koje se analiziraju, ali u sebi sadrže grešku mjerenja. U velikim skupovima podataka vrlo često je prikladno podatke grupirati na temelju nekih karateristika te modelirati svaku grupu podataka posebnim modelima kojima se opisuju svojstva varijabli kao što su njihov  međusobni odnos, mogućnost separacije, rub skupa vrijednosti varijabli, oblik skupa vrijednosti varijabli, dimenzije (duljinu,  površinu ili volumen) skupa vrijednosti ili općenito vektor parametara kojim su te varijable određene. Problem se u mnogim konkretnim situacijama može formulirati u obliku optimizacijskog problema u kome kriterijska funkcija cilja općenito nije niti konveksna niti diferencijabilna.  U svrhu rješavanja takvih problema razvijat će se efikasne, brze i točne numeričke procedure. Također, zbog postojanja pogreške u podacima, u svrhu razumijevanja i pravilne interpretacije rezultata koristit će se statistički modeli te će se istražiti odgovarajuća statistička svojstva.  ]]></summary_hr><summary_en><![CDATA[As a part of an attractive and active area of research known as big data analysis, optimization and statistical aspects of recognizing data sets properties will be analyzed. Research will be focused on clustering problems, deconvolution models and applications. The assumption is that the observed data sets represent the measured values of the variables to be analyzed but also that they contain a measurement error. In large data sets it is often appropriate to cluster data sets on the basis of certain characteristics and then apply specific models for each group that can describe variable properties such as relationships among them, possibility of separation, edges, specific form of the set of values, dimensions (length, surface or volume) of the set of values or general parameter vector which determines them.  The problem in many practical situations can be formulated as an optimization problem for which the objective function is generally neither differentiable nor convex. In order to solve such problems effectively, rapid and accurate numerical procedures will be developed. Also, due to errors in the data, in order to understand and correctly interpret the results, statistical models will be used and important statistical properties will be characterized. ]]></summary_en></project><project>
<id>4526</id><title_hr><![CDATA[Metoda usvojenih deformacija za konačne elemente slojevitih ploča i ljuski i njena primjena na probleme delaminacije ]]></title_hr><title_en><![CDATA[Assumed strain method in finite elements for layered plates and shells with application on layer delamination problem]]></title_en><user_id>1014</user_id><user_firstLast_name>Dragan Ribarić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-4775</code><acronim><![CDATA[ASDEL]]></acronim><duration>01.03.2017 - 28.02.2021</duration><status>Završio</status><financ_value>81.301,75 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Temeljne tehničke znanosti, Građevinarstvo, </scie_field_hr><scie_field_en>Basic engineering sciences, Civil engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Građevinski fakultet u Rijeci]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Civil Engineering]]></institution_en><team_members_id>527, 906, 25238, 26077, 28914, </team_members_id><team_members_names><![CDATA[Gordan Jelenić, Leo Škec, Marin Grbac, Ivan Hlača, Maedeh Ranjbar Zefreh, ]]></team_members_names><keywords_hr><![CDATA[teorija ploča, metoda konačnih elemenata, usvojene interpolacije deformacija, uslojene ploče, uslojene ljuske, delaminacija]]></keywords_hr><keywords_en><![CDATA[plate theory, finite element method, assumed strain, layered plates, layered shells, delamination]]></keywords_en><summary_hr><![CDATA[Predlažemo istraživački projekt iz bazičnih tehničkih znanosti koji će se baviti numeričkim analizama Mindlinovih tipova umjereno debelih ploča pomoću metode konačnih elemenata. Temeljem naših dobrih rezultata kod dizajniranja četverostraničnih i trostraničnih pločastih elemenata (s različitim brojem čvorova) uz pomoć metode usvojenih interpolacija deformacija a za formuliranje njihove matrice krutosti, predlažemo proširenje istraživanja na uslojene ploče u 2D prostoru i uslojene ravne i zakrivljene ljuske u 3D prostoru.Materijal koji povezuje slojeve će se u početnoj fazi opisti elastičnim konstitutivnim zakonom, ali slijedom naših uspješnih numeričkih eksperimenata na uslojenim gredama, vezni materijal između slojeva će se u narednoj fazi opisati mješovitim konstitutivnim zakonom s kohezivnom zonom i oštećenjem. Ovaj tip povezivanja slojeva bit će kasnije primijenjen na sve tipove konstruktivnih modela – ploča, ravnih i zakrivljenih ljuski. Numerički rezultati bit će uspoređeni s rezultatima modela ili eksperimentalnim rezultatima drugih autora iz literature.Istovremeno, neka jednostavna eksperimentalna istraživanja izraditi će se s opremom iz naših laboratorija. U završnoj fazi, izvesti ćemo složene eksperimente na stvarnim modelima s delaminacijom slojeva, te i njih usporediti s odgovarajućim numeričkim modelima.]]></summary_hr><summary_en><![CDATA[We propose a research project in basic technical sciences concerning the numerical analysis of the Mindlin type moderately thick plates and shells by the finite element method.Given our good results in designing quadrilateral and the triangular plate elements (with various number of nodes) by the assumed strain interpolation in the element stiffness formulation, we propose to extend our research to the layered plates in 2D space and the layered facet or curved shells in 3D space. The material connecting the layers will be modeled at first with a simple elastic constitutive law, but following our successful numerical experiments on the layered beams, the interfaces between layers will be further modeled by a mixed-mode cohesive-zone damage-type constitutive law. This kind of interconnection behavior will be then applied to all kinds of structural models - plates, facet and curved shells. The numerical results will be compared with the other models and the experimental results from literature.At the same time, experimental research will be performed using the equipment in our laboratories. We shall try to perform experiments with delamination of the real layered models and also compare them with the appropriate numerical models.]]></summary_en></project><project>
<id>4528</id><title_hr><![CDATA[Računalno učinkovito upravljanje učinskim pretvaračima u mikromrežama]]></title_hr><title_en><![CDATA[Computationally Efficient Predictive Control of Power Converters in Microgrids ]]></title_en><user_id>5578</user_id><user_firstLast_name>Jadranko Matuško</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-2519</code><acronim><![CDATA[PowerCon2]]></acronim><duration>01.03.2017 - 29.02.2020</duration><status>Prekinut</status><financ_value>84.629,37 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>2524, 7357, 20510, 25380, </team_members_id><team_members_names><![CDATA[Željko Jakopović, Fetah Kolonić, Tamara Hadjina, Renato Babojelić, ]]></team_members_names><keywords_hr><![CDATA[ Učinski pretvarači, Mikromreža, Modelsko prediktivno upravljanje, Izravno upravljanje snagom, FPGA]]></keywords_hr><keywords_en><![CDATA[Power converters, microgrid, Model predictive control, Direct power control, FPGA]]></keywords_en><summary_hr><![CDATA[Sve veći udio obnovljivih izvora u proizvodnji električne energije doveo je to pojave koncepta mikromreže. Mikromreža predstavlja skupinu distribuiranih i međusobno povezanih izvora, potrošača i spremnika energije i koja kao entitet može raditi spojena na distribucijsku mrežu ili potpuno odvojena od nje, tj. u tzv otočnom režimu rada. Tehnologija koja omogućuje jedan takav fleksibilan koncept su učinski pretvarači koji osiguravaju učinkovit i upravljan tok energije unutar mikromreže kao i prema distribucijskoj mreži. U zadnjoj dekadi modelsko prediktivno upravljanje se pojavilo kao metodologija koja omogućuje ne samo poboljšanje učinkovitosti rada učinskih pretvarača već i da se na sustavan način u proces projektiranja sustava upravljanja ugrade svi operativni zahtjevi, zahvaljujući jedinstvenom svojstvu da omogućava optimiranje radom sustava prema željenoj funkciji cilja, poštujući pritom sva ograničenja sustava. Glavna prepreka široj primjeni modelskog prediktivnog upravljanja u energetskim pretvaračima su značajni računski zahtjevi algoritma.Ovaj projekt ima za cilj razvoj računalno učinkovitih algoritama upravljanja mrežnim učinskim pretvaračima prikladnim za implementaciju u stvarnom vremenu. Projektni ciljevi su sljedeći: (i) razvoj računalno učinkovitog algoritma prediktivnog upravljanja mrežnim učinskim pretvaračem s PWM modulatorom, (ii) razvoj računalno učinkovitog algoritma prediktivnog izravnog upravljanja snagom mrežnog učinskog pretvarača (DPC) i (iii) implementacija i testiranje razvijenih algoritama na FPGA sklopovlju. Svi razvijeni algoritmi će biti implementirani  i testirani u istosmjernoj mikromreži u Laboratoriju za obnovljive izvore na Falultetu elektrotehnike i računarstva (LARES) ]]></summary_hr><summary_en><![CDATA[Increasing penetration of renewable sources in electricity generation has given rise to the concept of microgrids, a group of interconnected loads and distributed energy resources with clearly defined electrical boundaries that acts as a single controllable entity with respect to the grid connect and disconnect from the grid to enable it to operate in both grid-connected or islanded mode. An enabling technology for such the highly flexible concept are power converters, that allows for an efficient and well controlled energy flow within microgrid and to/from the main grid. In the last decade model predictive control has emerged as a methodology that is capable not only to further increase the efficiency of energy conversion but also to systematically integrate control and operational requirements into control system design process, owing to its unique feature to optimize system behaviour over an arbitrary objective function while respecting the system constraints at the same time. The main obstacle to broader applications of MPC based algorithms in power converters is the significant computational burden of the MPC algorithm. This project aims to develop computationally efficient algorithms for grid connected power converters suitable for real time-implementation.  In particular, the project aims: (i) to develop a computationally efficient PWM based predictive control algorithm for grid-tied power converters, (ii) to develop a computationally efficient Predictive Direct Power Control algorithm for grid-tied power converters and (iii) to implement the developed control algorithm for grid-tied power converters into high performance hardware platforms such as Field Programmable Gate Array (FPGA). All the developed control algorithms will be implemented and tested in a small scale DC microgrid in the Laboratory for Renewable Energy Sources (LARES) at Faculty of electrical Engineering and Computing, Zagreb.  ]]></summary_en></project><project>
<id>4529</id><title_hr><![CDATA[Lokalno ekološko znanje i ribarstvena istraživanja u Hrvatskoj: promjene u ribolovnoj i biološkoj raznolikosti mora ]]></title_hr><title_en><![CDATA[Local Ecological Knowledge and Fisheries Research in Croatia: Fishing and Marine Biodiversity Changes ]]></title_en><user_id>1215</user_id><user_firstLast_name>Jakov Dulčić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-5251</code><acronim><![CDATA[LEK-FishRes-CRO]]></acronim><duration>01.03.2017 - 31.08.2021</duration><status>Završio</status><financ_value>111.354,44 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Biotehnologija, Poljoprivreda, </scie_field_hr><scie_field_en>Biotechnology, Agriculture, </scie_field_en><institution_hr><![CDATA[Institut za oceanografiju i ribarstvo]]></institution_hr><institution_en><![CDATA[Institute of Oceanography and Fisheries]]></institution_en><team_members_id>4583, 2707, 20129, 3958, 668, 13709, 7025, 669, 283, 3959, 4946, </team_members_id><team_members_names><![CDATA[Pero Tutman, SANJA MATIĆ-SKOKO, Marcelo Kovačić, Dubravka Bojanić Varezić, Vanja Čikeš Keč, Igor Isajlović, Nedo Vrgoč, Barbara Zorica, Svjetlana Krstulović Šifner, Nika Stagličić, Branko Dragičević, ]]></team_members_names><keywords_hr><![CDATA[Jadransko more, ribarstvo, bioraznolikost, lokalno ekološko znanje, indikatorske vrste]]></keywords_hr><keywords_en><![CDATA[Adriatic Sea, fishery, biodiversity, local ecological knowledge, indicator species]]></keywords_en><summary_hr><![CDATA[Lokalno Ekološko Znanje (LEZ) je uvaženo kao alternativni izvor informacija o prisutnosti termofilnih i ne-zavičajnih vrsta te kvalitativnih i kvantitativnih pokazatelja njihove brojnosti. Pojave ne-zavičajnih vrsta sve se češće bilježe u Jadranu, što naglašava hitnost potrebe da se osigura odgovarajuće praćenje, brzo otkrivanje i brzo djelovanje. Središnji cilj projekta je procjena  potencijalne upotreba LEZ u razvoju baza znanja za upravljanje ribarstvom i zaštitom živih bogatstava mora. Strategija za ovu evaluaciju će biti dvosmjerna rasprava između ribara i drugih zainteresiranih dionika s jedne strane, te biologa s druge strane, oko određivanja indikatora o stanju ekosustava. U ovom projektu možemo razlikovati: Cilj 1: Razvoj i primjena LEZ intervju protokola (anketno ispitivanje), Cilj 2: Analiza podataka i usporedba podataka temeljenih na IZ s onima prikupljenim anketnim ispitivanjem LEZ, Cilj 3: Identifikacija tropikalizacije/meridionalizacije te promjena abundancije indikatorskih vrsta s naglaskom na invazivne vrste: pružanje osnovnih biološko-ribarstvenih podataka za pravovremeni odgovor. Ti ciljevi podrazumijevaju stvaranje proširene baze znanja za učinkovito upravljanje u ribarstvu, uključujući razmatranje ekosustava kao cjeline i obnove baze resursa za ribarstvo. Očekivani rezultati će nam dati uvid da li je LEZ prikladan način za rekonstrukciju ekoloških procesa (identifikaciju indikatora meridionalizacije/tropikalizacije, rekonstrukciju povijesnih trendova abundancije za indikatorske vrste/praćenje invazije alohtonih vrsta). Također ćemo moći procijeniti da li je LEZ protokol pogodan za otkrivanje značajnih promjena u morskom ekosustavu i da li je dovoljno robustan da pruži pouzdane podatke koji bi mogli poslužiti kao polazište za odgovarajuće aktivnosti. Očekujemo da će se odrediti biološke, ekološke i ribarstvene osobine najvažnijih vrsta indikatora u kontekstu ribarstva kao  i procesa meridionallizacije/tropikalizacije/invazije.]]></summary_hr><summary_en><![CDATA[Local Ecological Knowledge (LEK) is appreciated as an alternative source of information about the presence of thermophilic and non-indigenous species (NIS) and the qualitative and quantitative indicators of their numbers. The appearance of NIS are increasingly recorded in the Adriatic, which emphasizes the urgency of the need to ensure adequate monitoring, early detection and rapid action. The central objective of the project is to assess the potential use of LEK in the development of a knowledge base for fisheries management and protection of living marine resources. The strategy for this evaluation will be a two-way discussion between the fishermenand biologists about the determination of indicators of the ecosystem state. In this project, we can distinguish 3 objectives: Development and application of LEK Interview-protocol (survey questionnaire), Data analysis and comparison of research based knowledge (RBK) with LEK surveys data, Identification of tropicalization/meridionalization and abundance change for indicator species with emphasis on invasive species: providing baseline biological fisheries data for timely response. These objectives include the creation of an extended knowledge base for effective fisheries management. The expected results will give us insight into whether the LEK is convenient way for the reconstruction of ecological processes (identification of  indicator of meridionalization/tropicalisation, reconstruction of historical trends abundance of indicator species and invasion of NIS). We will also be able to assess whether the LEK protocol is suitable for the detection of significant changes in the marine ecosystem and is robust enough to provide reliable data that could serve as a starting point for the relevant activities. We expect to determine the biological, ecological and fishery characteristics of the most important types of indicators in the context of fisheries and processes of meridionallization/tropicalisation/invasion.]]></summary_en></project><project>
<id>4530</id><title_hr><![CDATA[Upravljanje dinamičkim sustavima]]></title_hr><title_en><![CDATA[Control of Dynamical Systems]]></title_en><user_id>866</user_id><user_firstLast_name>Martin Lazar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-2468</code><acronim><![CDATA[ConDyS]]></acronim><duration>01.03.2017 - 31.08.2021</duration><status>Završio</status><financ_value>131.926,47 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Dubrovniku]]></institution_hr><institution_en><![CDATA[University of Dubrovnik]]></institution_en><team_members_id>5431, 19770, 844, 5167, 19723, </team_members_id><team_members_names><![CDATA[Ivica Nakić, Ivana Palunko, Zoran Tomljanović, Domagoj Tolić, Irena Brdar, ]]></team_members_names><keywords_hr><![CDATA[upravljanje, parametarski-ovisni sustavi, vibracijski sustavi, adaptivno dualno upravljanje, optimalni dizajn]]></keywords_hr><keywords_en><![CDATA[control, parameter dependent problems, vibrational systems, adaptive dual control, optimal design]]></keywords_en><summary_hr><![CDATA[Ovim se projektom unutar hrvatske istraživačke mreže planira uspostaviti tim znanstvenika koji će se baviti matematičkom teorijom upravljanja i moći odgovoriti na najsuvremenije izazove povezane s problemima iz stvarnog života. Teorija upravljanja interdisciplinarno je područje koje povezuje matematiku s tehničkim znanostima i proučava dinamičke sustave s ulazima. Rezultati iz teorije upravljanja uspješno su primijenjeni na mnoge konkretne zadaće iz područja kao što su elektrotehnika, strojarstvo, transport, komunikacije, medicina itd. Iako postojeća teorija pruža odgovore na brojna fundamentalna i praktična pitanja, mnogi važni problemi su i dalje nerazriješeni. Daljnji napredak u modeliranju i upravljanju (fizičkim ili ekonomskim) sustavima povezan je s razvojem sofisticiranih matematičkih alata.U srži zanimanja projekta bit će značajne teme privlačne s teorijskoga, numeričkog i primijenjenoga gledišta, posebice: upravljanje vibracijskim i parametarski ovisnim sustavima, adaptivno dualno upravljanje, trošak upravljanja u višeskalnim zadaćama, optimalni dizajn i upravljanje autonomnim sustavima. Dobiveni rezultati bit će primijenjeni na probleme zračnih isporuka, čovjek-robot suradnje, upravljanja prometom itd. Spomenute teme i primjene važne su točke u tekućim međunarodnim istraživanjima a članovi skupine već imaju iskustva u radu na njima.Cilj je projekta pružiti nove teorijske metode i rezultate, analizirati pripadna numerička pitanja, razviti prikladni računski softver i potvrditi primjenu novorazvijenih metoda na sustavima koji proizlaze iz praktičnih problema, na taj način premošćujući međuprostor između teorijskih razmatranja i industrijskih primjena.U istraživanju ćemo, između ostalog, upotrebljavati pohlepne algoritme, redukciju modela, dvokriterijsku sintezu, Carlemanove nejednakosti, homogenizaciju, H-mjere, racionalne Krilovljeve metode, Pontrjaginov princip, teoriju Ljapunovljeve stabilnosti, poluklasičnu i harmonijsku analizu, te Liejeve grupe.]]></summary_hr><summary_en><![CDATA[This project aims at establishing a strong group in mathematical control theory within the Croatian research network, able to address cutting-edge issues emerging from real-life problems. Control theory is an interdisciplinary field combining engineering and mathematics that analyses dynamical systems with inputs. Results from control theory have been successfully applied to many problems in fields such as electrical and mechanical engineering, transportation, communication, medicine etc. Although the existing theory provides answers to a number of fundamental and practical questions, many important problems are still unresolved. In order to model and control (physical or economic) systems as closely as possible, there is an increasing demand for a sophisticated mathematical apparatus.The project will focus on the highly relevant topics attracting attention from theoretical, numerical and applicational points of view, in particular: control of vibrational and parameter dependent systems, adaptive dual control, cost of control in a multiscale setting, optimal design and control of autonomous systems. The results will be applied to problems of aerial delivery, human-robot cooperation, traffic control etc. This choice of topics is influenced by their importance in the current international research as well as by the background and expertise of the team members.The goal of the project is to provide new theoretical methods and results, analyse the related numerical issues, develop new computational software and verify applications of the newly developed methods to systems based on real-life scenarios, thereby bridging the gap between theoretical considerations and industrial applications.The tools and techniques we will use include greedy algorithms, model reduction, bicriterial synthesis, Carleman inequalities, homogenisation, H-measures, semi-classical and harmonic analysis, rational Krylov methods, Pontryagin principle, Lyapunov stability theory, and Lie groups.]]></summary_en></project><project>
<id>4533</id><title_hr><![CDATA[Prognostička vrijednost i dinamika cirkulirajuće mikroRNA u visokorizičnom mijelodisplastičnom sindromu liječenom 5-azacitidinom]]></title_hr><title_en><![CDATA[Prognostic significance and dynamics of circulating microRNA in high-risk MDS patients treated with 5-azacitidine ]]></title_en><user_id>19353</user_id><user_firstLast_name>Slobodanka Ostojić Kolonić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-5842</code><acronim><![CDATA[MDSmicroRNA]]></acronim><duration>20.03.2017 - 19.03.2021</duration><status>Prekinut</status><financ_value>17.604,35 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Clinical sciences, </scie_field_en><institution_hr><![CDATA[Klinička bolnica "Merkur", Zagreb]]></institution_hr><institution_en><![CDATA[Merkur Clinical Hospital, Zagreb]]></institution_en><team_members_id>19347, 19490, 19044, 19370, 20299, 19736, 3792, 20227, 20183, </team_members_id><team_members_names><![CDATA[INGA MANDAC ROGULJ, Martina Bogeljić Patekar, Vibor Milunović, Mirjana Mariana Kardum Paro, MARKO MARTINOVIĆ, ZORAN ŠIFTAR, Biljana Jelić Puškarić, ANA PLANINC PERAICA, Goran Rincic, ]]></team_members_names><keywords_hr><![CDATA[mijelodisplastični sindrom, microRNA, 5-azacitidin, prognostički faktori,visoki rizik ]]></keywords_hr><keywords_en><![CDATA[myelodysplastic syndrome, microRNA, 5-azacitidine, prognostic factors, high risk]]></keywords_en><summary_hr><![CDATA[Mijelodisplastični sindrom (MDS) predstavlja najučestaliju hematološku neoplazmu starije životne dobi. Karakteriziran je s jednom ili više citopenija te mogućnosti transformacije u sekundarnu akutnu mijeloičnu leukemiju.MikroRNA (miRNA) je podvrsta nekodirajućih RNA čija glavna funkcija leži u inhibiciji translacije mRNA preko različitih mehanizama u stanici. Cirkulirajuća miRNA se putem staničnih vezikula ili staničnom smrti otpušta u perifernu krv. Usprkos sve većem istraživanju cirkulirajuće miRNA u različitim entitetima, samo nekoliko studija je istražilo njezinu povezanost s MDS-om što čini racional predloženog projekta. Glavni cilj ove studije je istražiti ekspresiju i dinamiku ekspresije cirkulirajuće miRNA te njezin prognostički značaj u uniformnoj skupini 40 bolesnika s visokorizičnim MDS-om definiranim kao „INT-2“ i „High“ prema IPSS bodovnom sustavu liječenih 5-azacitidinom.. U studiji će biti određivane sljedeće miRNA: let-7-a, miRNA-21, miRNA-144, i miRNA-125a. Ove miRNA će biti određivane u multiplim vremenskim točkama studije: pri dijagnozi, nakon 4. i 6. ciklusa liječenja 5-azacitidinom, pri relapsu te leukemijskoj transformaciji kako bismo dobili uvid u alteraciju ekspresije cirkulirajućih miRNA zbog uvida u tijek i liječenje MDS-a.Specifični ciljevi studije su: usporediti ekspresiju cirkulirajućih miRNA u bolesnika s visokorizičnim MDS-om pri dijagnozi s ekspresijom cirukulirajućih miRNA u zdravih bolesnika, ispitati povezanost ekspresije cirkulirajuće miRNA s kliničkim i morfološkim karakteristikama bolesnika s visokorizičnim MDS-om pri dijagnozi i tijekom liječenja 5-azacitidinom te usporediti ekspresiju cirkulirajuće miRNA pri dijagnozi i leukemijskoj transformaciji MDS-a. S obzirom na činjenicu da je istraživanje cirkulirajućih miRNA u MDS-u tek na početku, ova studija bi mogla definirati pojedine miRNA koje bi u idućim istraživanjima mogle biti neivazivan i lako dostupan biomarker u prognozi  i liječenju MDS-a.]]></summary_hr><summary_en><![CDATA[Myelodysplastic syndrome (MDS) is the most common hematological neoplasm of elderly. It is characterized by one or more cytopenias and the possibility of transforming to the secondary acute myeloid leukemia.MicroRNAs (miRNA) is a sub-coding RNA whose main function is to inhibit translation of mRNA via different mechanisms in the cell. Circulating miRNA is released via cellular vesicles or  after cell death  into the peripheral blood. Despite growing research circulating miRNA in different entities, only a few studies have examined its association with MDS which makes rational of the proposed project.The main objective of this study was to investigate the expression and dynamics of circulating miRNA expression and its prognostic significance in uniform group of 40 patients with high-risk MDS defined as &#39;&#39;INT-2&#39;&#39; and &#39;&#39;High&#39;&#39; according to the IPSS scoring system treated with 5-azacitidine. The study will  analyze following miRNAs: let-7, a miRNA-21, miRNA-144 and miRNA-125a. These miRNA will be determined at multiple time points of the study: at diagnosis, after 4 and 6 cycles of treatment 5-azacitidine in relapse and leukemic transformation in order to get insight into the alteration of expression of circulating miRNA for insight into the course and treatment of MDS.The specific objectives of the study are: to compare the expression of circulating miRNA in patients with high-risk MDS at diagnosis and  in healthy patients, examine the relationship between circulating miRNA expression with clinical and morphological characteristics of patients with high-risk MDS at diagnosis and during treatment with 5-azacitidine and to compare the expression of circulating miRNA in diagnosis and leukemic transformation of MDS. Given the fact that the investigation of circulating miRNAs  in MDS is just beginning, this study could define specific miRNA that in future research could be noninvasive  and readily available biomarker in the prognosis and treatment of MDS.]]></summary_en></project><project>
<id>4546</id><title_hr><![CDATA[Istraživanja početka plastičnog toka metala kod hladne deformacije ]]></title_hr><title_en><![CDATA[Study of the Beginning of Plastic Flow of Metals During Cold Deformation]]></title_en><user_id>1351</user_id><user_firstLast_name>Stoja Rešković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-1270</code><acronim><![CDATA[MFSRIP062016]]></acronim><duration>01.03.2017 - 29.02.2020</duration><status>Završio</status><financ_value>55.325,50 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Metalurgija, </scie_field_hr><scie_field_en>Metallurgy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Metalurški fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Metallurgy]]></institution_en><team_members_id>3259, 19619, 19755, 274, 1332, 4702, 19501, 652, 24856, 24864, 24878, 25774, </team_members_id><team_members_names><![CDATA[Ladislav Lazić, Debruyne Dimitri, Pascal Lava, Suzana Jakovljević, Ivan Jandrlić, Tamara Aleksandrov Fabijanić, Tin Brlić, Ljerka Slokar, Vjeran Furlan, Filip  Skender, Karlo Komosar, Miloš Matvija, ]]></team_members_names><keywords_hr><![CDATA[čelik, hladna deformacija, orijentacija zrna, niobijevi precipitati, brzina deformacije, Lüdersove linije,  termografija, DIC]]></keywords_hr><keywords_en><![CDATA[steel, cold deformation, niobium precipitates, strain rate, Lüders bands, thermography, DIC]]></keywords_en><summary_hr><![CDATA[Razvojem suvremenih metoda ispitivanja danas se u svijetu provode istraživanja toka materijala i raspodjele naprezanja u zoni deformacije. Posebna pozornost posvećuje se istraživanju početka plastičnog toka materijala, naročito u elastoplastičnom području. Zapaženo je da kod nekih niskougljičnih čelika i Al legura, nakon dostizanja granice proporcionalnosti, dolazi do pojave L?dersovih linija.  Različita su tumačenja  ove pojave. U ovom projektu provesti će se istraživanje na niskougljičnom i istom čeliku mikrolegiranom s različitim sadržajem niobija. Provesti će se istraživanja na čeliku istog kemijskog sastav a koji imaju različitu veličinu i raspored niobijevih precipitata. Primjenom suvremenih metoda visioplastičnosti, termografije, digitalne korelacije slike, te pretražne i transmisijske elektronske mikroskopije istražiti će se utjecaj niobija na početak i tok deformacije. Istodobno sa statičkim vlačnim pokusom provesti će se mjerenja s termografskom i optičkom kamerom. Istražiti će se utjecaj različitih parametara (brzine deformacije, stupnja deformacije, sadržaja mikrolegirajućeg elementa niobija, veličine i rasporeda niobijevih precipitata) na elastično, elastoplastično i plastično ponašanje čelika, te formiranje zone deformacije i raspodjelu naprezanja u zoni deformacije. Posebna pozornost će se posvetiti istraživanju utjecajnih parametara na formiranje i propagaciju Lüdersovih linija u elastoplastičnom području. Istražiti  će se utjecaju početne strukture,  veličine i orijentacije zrna na pojavu i propagaciju L?dersovih linija. Detaljno će se istražiti strukturne promjene koje nastaju u čeliku kod formiranja Lüdersove linije i u različitim fazama njene propagacije kroz zonu deformacije, pri različitim brzinama deformacije kod čelika koji imaju različit sadržaj mikrolegirajućeg elementa niobija. ]]></summary_hr><summary_en><![CDATA[With the development of modern testing methods, today in the world researches are conducted on material flow and stress distribution in the deformation zone. Special attention is paid to study the beginning of plastic flow of materials, especially in elastoplastic area. It has been noted that in some low carbon steels and aluminium alloys, after reaching the proportionality limit, there is occurrence of Lüders bands. There are different interpretations of this phenomenon. In this project research will be carried out on low carbon steel and the same steel microalloyed with different contents of niobium. Research will be carried out on steels with same chemical composition but with different size and arrangement of niobium precipitates. By applying modern methods of visioplasticity, thermography, digital image correlation, scanning and transmission electron microscopy, the influence of niobium on beginning and the flow of plastic deformation will be investigated. Simultaneously with tensile tests, measurements with thermographic and optical camera will be carried out. The impact of various parameters (strain rate, deformation degree, content of microalloying element niobium, size and distribution of precipitates of niobium) on the elastic, elastoplastic and plastic behaviour of steel will be investigated, and same on the forming of deformation zone and stresses distribution in deformation zone. Special attention will be paid to the study of parameters affecting the formation and propagation of Lüders bands in elastoplastic area. It will be explored the impact of the initial structure, size and orientation of the grains on the occurrence and propagation of Lüders bands. In detail will be explored the structural changes that occur in the steel during the formation of Lüders bands and at different stages of its propagation through the deformation zone, at different strain rates of steels which have different content microalloying element niobium.]]></summary_en></project><project>
<id>4548</id><title_hr><![CDATA[Inovativni postupci uklanjanja AFM1 biofiksatorima iz mlijeka]]></title_hr><title_en><![CDATA[Innovative methods for the removal of AFM1 using biofixators from the milk]]></title_en><user_id>416</user_id><user_firstLast_name>Ksenija Markov</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-4306</code><acronim><![CDATA[BIOMYCOFIX-MILKFREE]]></acronim><duration>01.03.2017 - 28.02.2019</duration><status>Završio</status><financ_value>64.249,92 eur</financ_value><scie_area_hr>Biotehničke znanosti, Biomedicina i zdravstvo, Prirodne znanosti, </scie_area_hr><scie_area_en>Biotechnical sciences, Biomedicine and health sciences, Natural sciences, </scie_area_en><scie_field_hr>Biotehnologija, Kemija, Javno zdravstvo i zdravstvena zaštita, </scie_field_hr><scie_field_en>Biotechnology, Chemistry, Public health and health services, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Food Technology and Biotechnology]]></institution_en><team_members_id>214, 19402, 19401, 19513, 19497, 19514, 19515, 19662, </team_members_id><team_members_names><![CDATA[Jadranka Frece, Željko  Jakopović, Iva Čanak, Jasna Bošnir, Željka Kuharić, Sonja Serdar, željka pavlek, Martina Ivešić, ]]></team_members_names><keywords_hr><![CDATA[AFM1, biofiksatori, bakterije mliječne kiseline, ß-glukan, inovativne metode uklanjanja AFM1, nutritivna vrijednost mlijeka]]></keywords_hr><keywords_en><![CDATA[AFM1, biofixators, lactic acid bacteria, ß-glucan, innovative methods of removing AFM1, nutritive value of milk]]></keywords_en><summary_hr><![CDATA[Praćenjem EU RASFF sustava žurnog uzbunjivanja primjećena je značajna prisutnost mikotoksina u hrani za ljude i životinje. S obzirom na toksičnost mikotoksina od iznimne je važnosti kontrolirati njihovu prisutnost i količinu u hrani. Nakon što je dokazano da kao produkt biološke pretvorbe aflatoksina B1 u mliječnim žlijezdama sisavaca hranjenih krmom koja je sadržavala spomenuti aflatoksin B skupine, nastaje aflatoksin M1, koji  je izoliran iz mlijeka i urina životinja, postoji zabrinutost oko ulaska mikotoksina u prehrambeni lanac čovjeka, ne samo kroz žitarice i proizvode od žitarica već i kroz meso, jaja, mlijeko i mliječne proizvode zbog faktora prijenosa („carry over” efekt). Međutim, važno je napomenuti da još uvijek nisu pronađene točne, pouzdane i učinkovite strategije uklanjanja prisutnih mikotoksina u hrani i/ili krmivu te se stoga istraživanja mogućnosti uklanjanja mikotoksina mikrobnim kulturama i njihovim staničnim komponentama nameću kao moguća alternativa postojećim fizikalnim i kemijskim metodama detoksifikacije. Cilj projekta je  istražiti primjenu bakterija mliječne kiseline (BMK) i ß- glukana i mogući način uklanjanja dobivenog kompleksa s mikotoksinom iz mlijeka. Kako bi se ispitao  utjecaj odabranih postupaka na kvalitetu mlijeka određivati će se i parametri kvalitete mlijeka: masti, bjelančevine, ugljikohidrati, laktoza. Cilj projekta  je i potaknuti proizvođače mlijeka  na kontinuirano praćenje AFM1 u mlijeku, budući da najveća odgovornost za kvalitetu i zdravstvenu ispravnost mlijeka leži na subjektima u poslovanju s hranom. Dobiveni rezultati pokazat će kako se primjenom BMK i  ß- glukana samostalno ili u kombinaciji može ukloniti AFM1  iz mlijeka ili svesti na propisane najveće dozvoljene količine (NDK). Nadalje rezultati ovog projekta biti će od značaja proizvođačima mlijeka i mliječnih proizvoda, te resornim ministarstvima, zbog njihove primjene u svrhu smanjenja gospodarskih šteta koje nastaju prilikom kontaminacije mlijeka AFM1.]]></summary_hr><summary_en><![CDATA[The EU RASFF system observed the significant presence of mycotoxins in food for humans and animals. Due to the toxicity of mycotoxins it is extremely important to control their presence and quantity in foods. After it was shown that the product of biological conversion of aflatoxin B1 in the mammary glands of mammals fed with feed containing said aflatoxin B group, aflatoxin M1 is formed, which is isolated from the milk and urine of animals, there are concerns about mycotoxins entering human food chain, not only through cereals and cereal products, but also through meat, eggs, milk and milk products if the animals were fed with feed contaminated with molds that synthesize mycotoxins, or with mycotoxins alone (carry over). It is important to note that accurate, reliable and efficient strategy for removal of present mycotoxins in food and feed have not yet been found, therefore research of opportunities for removing mycotoxins with microbial cultures and their cellular components are imposed as an alternative to existing physical and chemical methods of detoxification. The project aims to explore the application of lactic acid bacteria and ß-glucan and possible removal of resulting complex with a mycotoxin from the milk. In order to examine the impact of selected methods on milk quality, following parameters will be determined: fat, protein, carbohydrates, lactose. The project also aims to encourage milk producers to continuously monitor AFM1 in milk, since the greatest responsibility for the quality and safety of milk is the subjects dealing with food. The results will show how the application of LAB and ß-glucan alone or in combination can remove AFM1 from milk or reduce to a prescribed maximum permissible limit. Furthermore, the results of this project will be of great significance to the milk and dairy products producers as well as the relevant ministries, because of their application to reduce economic damages which results from the milk contamination with AFM1.]]></summary_en></project><project>
<id>4550</id><title_hr><![CDATA[Uloga unutarstaničnog života Francisella tularensis u patogenezi eksperimentalne tularemije]]></title_hr><title_en><![CDATA[The role of the intracellular life cycle of Francisella tularensis for the pathogenesis of experimental tularemia]]></title_en><user_id>114</user_id><user_firstLast_name>Marina Šantić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-9003</code><acronim><![CDATA[FRANCYCLE]]></acronim><duration>05.06.2017 - 04.11.2021</duration><status>Završio</status><financ_value>121.441,37 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, Clinical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Medicine]]></institution_en><team_members_id>6961, 115, 12452, 117, 3102, 20006, 20145, 25206, 27882, </team_members_id><team_members_names><![CDATA[Maja Abram, Mateja Ožanič, Mirna Mihelčić, Valentina Marečić, Sanja Štifter, Jiri Stulik, Marek Link, Ina Kelava, Maša Knežević, ]]></team_members_names><keywords_hr><![CDATA[Francisella, FPO, sazrijavanje fagosoma/vakuole, autofagija, in vitro, in vivo]]></keywords_hr><keywords_en><![CDATA[Francisella, FPI, phagosome/vacuole maturation, autophagy, in vitro, in vivo]]></keywords_en><summary_hr><![CDATA[Francisella tularensis je gram-negativna, visoko infektivna, fakultativno unutarstanična bakterija koja uzrokuje tularemiju. Unutarstanični život F. tularensis je jedinstven u odnosu na druge unutarstanične bakterije. Fagosom koji sadrži francizelu (FCP - Francisella containing phagosome) zaustavljen je u fazi kasnog nezakiseljenog endosoma, nakon čega slijedi postupni bakterijski izlazak u citosol. Očito je da Francisella kruži kroz različite unutarstanične odjeljke; FCP i vakuolu koja sadrži francizelu (FCV – Franicisella containing vacuole). Zbog važnosti ovih staničnih odjeljaka u uspostavi i održavanju infekcije, po prvi put ćemo izolirati FCP i FCV iz makrofaga. Ovo je potpuno novi pristup u razumijevanju njihove uloge u unutarstaničnom životu francizela. Nadalje, pretpostavljamo da se značajni dio interakcije sa citosolom domaćina ostvaruje putem autofagije. Moguće je da, u kasnijoj fazi infekcije, Francisella oblikuje oštećenu FCV u autofagnu vakuolu. Brojna su istraživanja usredotočena na dio bakterijskog genoma poznatijem kao Francizela patogeni otok (FPO). Mnoge FPO mutante pokazuju jednoobrazan fenotip karakteriziran nemogućnošću bijega iz fagosoma, izostankom unutarstanične replikacije te gubitkom virulencije in vivo. Želimo dokazati da su FPO proteini (PdpC, IglC, IglI, PdpE i IglG) koji su efektori tipa VI sekrecijskog sustava uključeni u regulaciju procesa autofagije. Autofagija se smatra jednim od efektorskih mehanizama urođene imunosti protiv unutarstaničnih bakterija. Podaci o ulozi autofagije u regulaciji citokinske mreže tijekom tularemije su još uvijek rijetki i proturječni. Stoga bi naša daljnja istraživanja, posebno u modelu Atg5 transgeničnih miševa, trebala pridonijeti boljem razumijevanju autofagije kao imunom odgovoru na infekciju francizelom. Očekivani rezultati doprinijet će rasvjetljavanju patogeneze tularemije te pridonijeti razvoju novih terapijskih i preventivnih strategija baziranih na autofagiji.]]></summary_hr><summary_en><![CDATA[Francisella tularensis is a highly virulent facultative intracellular pathogen that causes  disease tularemia. The intracellular lifestyle of F. tularensis is unique compared to other intracellular pathogens. The Francisella-containing phagosome (FCP) is arrested at a non-acidified late endosome-like stage, which is followed by gradual bacterial escape into the cytosol. It is obvious that Francisella cycles through different intracellular compartments; FCP and the Francisella-containing vacuole (FCV). Because of the importance of these subcellular compartments during infection, we will establish a novel method of isolating the FCP/FCV from macrophages. This is an innovative approach in understanding their role in Francisella intracellular life cycle. Secondly, we proposed that the great part of communication with the host cytosol environment is accomplished by autophagy. We assume that Francisella reseal damaged FCV into the autophagic vacuole later during the infection. Many studies have been focused on a genomic region called the Francisella pathogenicity island (FPI). Some of the FPI mutants show a uniform phenotype characterized by lack of phagosomal escape, no intracellular replication, and a loss of virulence in vivo. We expect to find that FPI proteins, PdpC, IglC, IglI, PdpE, and IglG that are effectors of the type VI secretion system are also involved in manipulation of autophagy machinery. Autophagy is regarded as one of the innate immunity effectors against intracellular bacteria. However, the data on the role of autophagy in the regulation of cytokine networks by Francisella are still unknown. We propose a new concept using transgenic Atg5 mouse that should contribute to a better understanding of autophagy as host immune response to Francisella infections. The project will contribute to understanding the pathogenesis of tularemia, providing opportunities for the development of novel autophagy-based therapeutic and preventive strategies.]]></summary_en></project><project>
<id>4552</id><title_hr><![CDATA[Ekstrakcije bioaktivnih spojeva iz mediteranskog bilja sa “zelenim otapalima” primjenom visokonaponskog pražnjenja]]></title_hr><title_en><![CDATA[High voltage discharges for green solvent extraction of bioactive compounds from Mediterranean herbs]]></title_en><user_id>469</user_id><user_firstLast_name>Anet Režek Jambrak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-1913</code><acronim><![CDATA[GREENVOLTEX]]></acronim><duration>01.03.2017 - 28.02.2021</duration><status>Završio</status><financ_value>132.225,10 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Prehrambena tehnologija, Poljoprivreda, Biotehnologija, </scie_field_hr><scie_field_en>Food technology, Agriculture, Biotechnology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Food Technology and Biotechnology]]></institution_en><team_members_id>19322, 19306, 19304, 130, 403, 4728, 3170, 5722, 591, 6854, 20213, 20245, 21336, 25273, 24300, 2853, 1342, </team_members_id><team_members_names><![CDATA[Farid Chemat, Francisco Jose Barba, Francesco Donsi&amp;#39; Donsi&amp;#39;, Jasminka Giacometti, Tea  Bilušić, Greta Krešić , Mara Banović, Sanda Pleslić, Marija  Badanjak Sabolović, Nikolina Mrduljaš, Slaven Jurić, Marko Viskić, Igor Dubrović, Marinela Nutrizio, Predrag Putnik, Adela Krivohlavek, Irena Žuntar, ]]></team_members_names><keywords_hr><![CDATA[visokonaponsko pražnjenje, plazma, ekstrakcije, zelena otapala, mediteransko bilje]]></keywords_hr><keywords_en><![CDATA[high voltage discharges, plasma, extraction, green solvents, mediteranean herbs]]></keywords_en><summary_hr><![CDATA[Prehrambena industrija intenzivno razvija ne-toplinske tehnike obrade hrane kao što su netoplinske plazme, pulsirajuće električno polje, visoki hidrostatski tlak te ultrazvuk visokog intenziteta. Nove netoplinske tehnike omogućavaju provedbu ekstrakcije bioaktivnih tvari bez primjene organskih otapala pri čemu se kao otapalo može koristiti voda ili neka tzv. “zelena otapala” npr. voda, D-limonen, dimetilkarbonat (DMC), etanol, etil-acetat i dr. Jedna od takvih obećavajućih tehnika je i visokonaponsko električno pražnjenje-plazma. Projektom će se nastojati ostvariti sljedeći ciljevi:C1 Razviti uređaj za generiranje plazme koji se sastoji od generatora plazme i reaktora s različitim konfiguracijama elektroda pri čemu će se koristiti inovativan pristup generiranja visokog napona DC napajanja pomoću moderne solid state tehnologije. C2 Utvrditi će se učinkovitost ekstrakcije bioaktivnih komponenti i eteričnih ulja iz autohtonog mediteranskog bilja (list masline, ružmarin, kadulja, mravinac, timijan, majčina dušica) plazmom uz upotrebu vode i „zelenih„ otapala. C3 Optimizirati će se djelovanje inovativnog uređaja za generiranje plazme tijekom ekstrakcija kako bi dobili što veće iskorištenje postupka.C4 Utvrditi će se biološka aktivnost dobivenih ekstrakata putem analitičkih metoda, te ispitati mogućnost nastajanja eventualnih oksidativnih promjena tijekom postupaka ekstrakcija. C5  Dobiveni ekstrakti će se na odgovarajući način izolirati te stabilizirati primjenom postupaka liofilizacije i/ili inkapsulacije.Predloženo istraživanje doprinijeti će području istraživanja, na način da će biti konstruiran inovativni uređaj za produkciju plazme direktno u tekućinama kojim će se moći provesti brza i učinkovita ekstrakcija bioaktivnih komponenata i eteričnog ulja iz autohtonog mediteranskog bilja. Novom netoplinskom tehnikom ekstrakcije nastojat će se smanjiti vrijeme ekstrakcije, upotreba otapala, onečišćenje okoliša i ukupan energetski utrošak uz istovjetno iskorištenje.]]></summary_hr><summary_en><![CDATA[The food industry is rapidly developing new non-thermal food processing techniques like non-thermal plasma, pulsed electric field, high hydrostatic pressure and high intensity ultrasound. New non-thermal techniques are considered “green” extraction methods for isolation of bioactive compounds, because conventionally used organic solvents for extraction can be replaced by water or other green solvents like D-limonen, dimethylcarbonate (DMC), ethanol, ethyl-acetate etc. High voltage electrical discharge-plasma (HVED) is one of new promising green techniques. The aims of this project will be accomplished and they include:O1 Design and development an equipment for generating plasma which consists of: plasma generator and reactor with different configuration of electrodes. During designing of plasma generator, new innovative approach for generating high voltage DC supply by usage of modern solid state technology will be applied.O2 To established effectiveness of extraction of bioactive compounds and volatile oils from autochthonous Mediterranean herbs (olive leaf, rosemary, sage, oregano, thyme, wild thyme), with plasma by usage of water and green solvents O3 To increase yield of process by optimisation of the operation mode of innovative equipment for generating plasma.O4 Biological activity of obtained extracts will be determined by analytical methods, and investigated the possibility of oxidative changes during extraction processO5 Obtained extracts will be isolated and stabilized by lyophilization and/or encapsulation. This Project proposal will contribute to the research area by constructing a new innovative equipment for liquid plasma which will be useful for quick and efficient extraction of bioactive compounds and volatile oils from leaves of autochthonous Mediterranean herbs. By new, non-thermal extraction technique, the attempt is to reduce duration of extraction, solvent usage, environment pollution and total energy consumption.]]></summary_en></project><project>
<id>4554</id><title_hr><![CDATA[Uporaba podataka daljinskih istraživanja dobivenih različitim 3D optičkim izvorima u izmjeri šuma]]></title_hr><title_en><![CDATA[Retrieval of Information from Different Optical 3D Remote Sensing Sources for Use in Forest Inventory]]></title_en><user_id>1275</user_id><user_firstLast_name>Ivan  Balenović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-7686</code><acronim><![CDATA[3D-FORINVENT]]></acronim><duration>01.03.2017 - 28.02.2021</duration><status>Završio</status><financ_value>96.622,20 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Šumarstvo, </scie_field_hr><scie_field_en>Forestry, </scie_field_en><institution_hr><![CDATA[Hrvatski šumarski institut]]></institution_hr><institution_en><![CDATA[Croatian Forest Research Institute]]></institution_en><team_members_id>19806, 20222, 819, 24108, 24045, 24107, </team_members_id><team_members_names><![CDATA[Anita  Simic Milas, Ante Seletković, Maša Zorana Ostrogović Sever, Danijela Ivanković, Goran Tijan, Luka Jurjević, ]]></team_members_names><keywords_hr><![CDATA[izmjera šuma, uređivanje šuma, daljinska istraživanja, digitalna fotogrametrija, GIS]]></keywords_hr><keywords_en><![CDATA[forest mensuration, forest management, remote sensing, digital photogrammetry, GIS]]></keywords_en><summary_hr><![CDATA[Šuma je najrašireniji kopneni ekosustav na Zemlji te pruža mnogo direktnih i indirektnih dobrobiti ljudskom čovječanstvu. Potrajno gospodarenje šumama uz osiguranje njenih mnogobrojnih funkcija i usluga zahtjeva prostorno određene  informacije o stanju i razvoju šume koje se uglavnom prikupljaju u okviru inventure šuma. Prikupljanje podataka o šumama na tradicionalni način, terenskom izmjerom, pruža točne informacije, ali zahtijeva dugotrajan i intenzivan rad, a u pojedinim slučajevima pristup određenim šumskim područjima je otežan ili čak nemoguć. Upravo iz tog razloga prepoznat je potencijal upotrebe metoda daljinskog istraživanja (DI) pri inventuri šuma. Unatoč dostupnosti različitih podataka DI i velikom potencijalom za njihovo korištenje pri izmjeri šuma, u Hrvatskoj, kao i u mnogim drugim zemljama, izmjera šuma se još uvijek temelji samo na tradicionalnoj terenskoj izmjeri.Stoga je glavni cilj predloženog projekta razviti i testirati metode temeljene na različitim 3D optičkim podacima DI za primjenu u inventuri šuma, a u svrhu poboljšanja učinkovitosti i ekonomičnosti postojećih terenskih načina prikupljanja podataka. Konkretno, ispitati će se točnost proizvoda (oblak točaka, DMVK, ortofoto) izvedenih iz različitih 3D podataka DI (aerosnimke, satelitske snimke, snimke bespilotne letjelice) i različitih prostornih rezolucija, za procjenu varijabli pojedinačnih stabala i šumskih sastojina na raznim prostornim razinama. Istražiti će se i mogućnost njihove primjene u automatskoj segmentaciji i klasifikaciji pojedinačnih stabala i šumskih sastojina. Općenito, a posebice u zemljama jugoistočne Europe, nedostaju komparativne studije koje se bave usporedbom podataka o šumama dobivenih iz različitih 3D optičkih senzora DI. Ovo istraživanje će dati prve informacije o kvaliteti i točnosti navedenih podataka i njihovih produkata te mogućnosti njihove primjene u inventuri šuma. Stoga, će dobiveni rezultati biti od iznimnog značaja i interesa za šumarsku znanost i praksu.]]></summary_hr><summary_en><![CDATA[As the most widely distributed terrestrial ecosystem on the earth, forests provide many direct and indirect benefits to human well-being. Sustainable management of forests’ multiple functions and services requires spatially explicit information about forests state and development, which are usually acquired through forest inventories.Although traditional field-based forest inventory can provide relatively accurate information, the process is time-consuming and labour intensive, and in some cases access to certain forest areas is not possible. Therefore, the potential of remote sensing (RS) application in forest inventory have been long recognized by both researchers and practicing foresters. Despite the availability of various RS data and great potential for their use, in Croatia as well as in many other countries, forest inventory is still based only on traditional field methods.Therefore, the main goal of this proposal is to develop and evaluate methods and workflows for forest inventory applications based on different 3D RS data, aiming to improve efficiency and cost-effectiveness of current field-based inventory practices. Specifically, the accuracy of products (image-based point cloud, CHM, orthoimage) derived from various 3D RS data (UAS, airborne, satellite stereo images) with different spatial resolutions will be evaluated for estimating the main tree and forest stand attributes at various spatial levels. Secondly, automatic segmentation and classification of both individual trees and forest stands using above mentioned products will be investigated. A comparison studies dealing with performance of different 3D RS data in forest inventory are lacking, especially in the South-east European region. Therefore, this research will provide first assessments of quality and accuracy of forest information derived from different 3D RS data and its products. Thus, the results of this research will be of interests for both forestry researchers and industry.]]></summary_en></project><project>
<id>4555</id><title_hr><![CDATA[Primjena visokog hidrostatskog tlaka u proizvodnji funkcionalnih sokova na bazi voća i povrća]]></title_hr><title_en><![CDATA[High Hydrostatic Pressure Processing of Functional Fruit and Vegetable Juices ]]></title_en><user_id>2657</user_id><user_firstLast_name>Damir Ježek</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-4006</code><acronim><![CDATA[HIGHPRESS-JUICE]]></acronim><duration>01.03.2017 - 31.05.2021</duration><status>Završio</status><financ_value>132.590,09 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Prehrambena tehnologija, </scie_field_hr><scie_field_en>Food technology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Food Technology and Biotechnology]]></institution_en><team_members_id>20146, 2663, 13352, 19401, 214, 1243, 1056, 20151, 7761, </team_members_id><team_members_names><![CDATA[Marko Marelja, Sven Karlović, Tomislav Bosiljkov, Iva Čanak, Jadranka Frece, Verica Dragović-Uzelac, Zoran Zorić, Marko Škegro, Nada Vahčić, ]]></team_members_names><keywords_hr><![CDATA[visoki hidrostatski tlak, funkcionalni sokovi, inaktivacija mikroorganizama, organoleptička analiza, bioaktivne tvari, voće, povrće]]></keywords_hr><keywords_en><![CDATA[high hydrostatic pressure, functional juices, inactivation of microorganisms, sensory analysis, bioactive compounds, fruit, vegetables]]></keywords_en><summary_hr><![CDATA[Svježi sokovi te smoothie od voća i povrća se mogu smatrati funkcionalnim proizvodima s visokim udjelom bioaktivnih spojeva kojima se pripisuju pozitivni učinci na zdravlje. Kako bi se sačuvali bioaktivni spojevi, poželjna senzorska svojstva te mikrobiološka stabilnost tijekom skladištenja, konzerviranje ovih proizvoda vrši se primjenom novih tehnika poput visokog hidrostatskog tlaka (VHT). Stoga je cilj ovog projekta istražiti biološki potencijal različitih vrsta voća i povrća (obzirom na zastupljenost bioaktivnih spojeva-karotenoida, klorofila, antocijana, polifenola), s krajnjim ciljem formuliranja voćnih ili povrtnih sokova i smoothija koji će sadržavati visok i izbalansiran udio bioaktivnih spojeva, dobrih senzorskih svojstava te veće stabilnosti tijekom skladištenja. Sokovi će se proizvoditi hladnim prešanjem nakon čega će se dio podrvgnuti pasterizaciji, a dio će se tretirati VHT. Određivat će se utjecaj VHT na učinkovitost postupka homogenizacije te disperziju čestica pulpe u obrađenim uzorcima. Za svaku vrstu proizvoda će se definirati optimalni uvjeti pri kojima se postižu najbolja nutritivna, biološka i  senzorska svojstva te mikrobiološka stabilnost. Provedena istraživanja predstavljaju dobru bazu za razvijanje  novih funkcionalnih proizvoda na bazi voća i povrća u kojima bi bili sadržani ciljani bioaktivni spojevi iz različitih skupina, koji bi zahvaljujući kombiniranom i sinergijskom djelovanju osigurali izrazita biološka te poželjna senzorska svojstva.]]></summary_hr><summary_en><![CDATA[Fresh juices and smoothies based on fruit and vegetables are considered to be functional products with a high amount of bioactive compounds, which have a positive influence on health. To preserve bioactive compounds, sensory properties, and microbiological stability during storage, preservation of those products is performed using new non-thermal technologies such as high hydrostatic pressure (HHP). In that regard main goal of this project is to investigate the biological potential of different fruits and vegetables (based on the proportion of bioactive compounds – carotenoids, chlorophylls, anthocyanins, polyphenols), with the end goal to formulate recipes and process parameters for fruit or vegetable juices and smoothies. Those products will contain a high and balanced share of bioactive compounds, have excellent sensory properties and longer shelf life. Juices will be produced using cold press technique, and afterwards processed using conventional pasteurisation or high hydrostatic pressure. Influence of HHP process parameters on the homogenization and particle dispersion in samples will be determined. For every type of product, optimal HHP processing conditions will be determined, to ensure best nutritive, biological and sensory properties, as well as microbiological stability. Conducted research is a solid base for development of new functional fruit and vegetable based products, which would contain targeted bioactive compounds from different groups. Those compounds will have combined and synergistic effect and ensure exceptional biological and sensory properties.]]></summary_en></project><project>
<id>4557</id><title_hr><![CDATA[Istraživanje ravnoteže mikrobioma debelog crijeva]]></title_hr><title_en><![CDATA[Exploring Gut Microbiome Equilibrium]]></title_en><user_id>5774</user_id><user_firstLast_name>Antonio Starčević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-3509</code><acronim><![CDATA[MicroEquilibrium]]></acronim><duration>02.05.2017 - 01.07.2021</duration><status>Završio</status><financ_value>126.352,11 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo, Biotehničke znanosti, Prirodne znanosti, Tehničke znanosti, Društvene znanosti, </scie_area_hr><scie_area_en>Biomedicine and health sciences, Biotechnical sciences, Natural sciences, Technological sciences, Social sciences, </scie_area_en><scie_field_hr>Biotehnologija u biomedicini, Matematika, Biologija, Računarstvo, Kliničke medicinske znanosti, Biotehnologija, Prehrambena tehnologija, Nutricionizam, </scie_field_hr><scie_field_en>Biotechnology in Biomedicine, Mathematics, Biology, Computer sciences, Clinical sciences, Biotechnology, Food technology, Nutrition, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Food Technology and Biotechnology]]></institution_en><team_members_id>19799, 20165, 7639, 4282, 799, 798, 18967, 20256, 517, 1040, 110, 3536, 28256, 28774, </team_members_id><team_members_names><![CDATA[Dina Rešetar, Ivona Višekruna, Marcel Lipej, Ivana Banić, Jagoda Šušković, Blaženka Kos, Martina Marijanović, Ena Melvan, Damir  Oros, Miran Čoklo, Jurica Žučko, Mario Cindrić, Jasenka Škrlin, Ema Svetličić, ]]></team_members_names><keywords_hr><![CDATA[mikrobiom, bioreaktor, mikrobiota, ravnoteža, probiotik, prebiotik, pretilost, fekalni transplant, personalizacija, enterotip]]></keywords_hr><keywords_en><![CDATA[microbiome, bioreactor, microbiota, equilibrium, probiotic, prebiotic, obesity, fecal transplant, personalization, enterotype]]></keywords_en><summary_hr><![CDATA[MicroEquilibrium želi in vitro, u bioreaktoru uspostaviti i održavati dinamičku ravnotežu mikroorganizama definiranu  postojanjem pozitivne kovarijance između udjela rodova Bacteroides, Prevotella i Ruminococcus u inokulumu (fecesu) i biomasi izuzetoj nakon provedenog šaržnog uzgoja s prihranom u bioreaktoru. U tako uspostavljenom modelu ispitivati će se utjecaj niza kombinacija prebiotika i pro-lijekova na promjenu ravnoteže sa ciljem pomaka prema enterotipu karakterističnom za fenotip zdravstveno poželjnog BMI-a. Jedino interdisciplinarnim pristupom koji uključuje sistemsku biologiju,genomiku, proteomiku,bioinformatiku,kliničku medicinu,antropologiju,matematičko modeliranje i društveni izazov pretilosti moguće je istraživati problematiku kompleksnih mikrobnih zajednica našeg probavila. Prednost ovakvog pristupa jest u činjenici da se istraživanjem in vitro, može efikasno eliminirati niz čimbenika i etičkih pitanja nad kojima inače nemamo kontrolu. Potencijal rezultata koje ovo istraživanje može generirati jest u mogućnosti personalizacije terapeutika baziranih na standardiziranim i neškodljivim dodacima prehrani u vidu prebiotika i pro-lijekova gdje je efikasnost ispitana u uvjetima in vitro. Uvođenje testiranja učinkovitosti in vitro, u bioreaktoru iznad je trenutnog stanja tehnike kada su u pitanju pretilost i dodaci prehrani gdje se sve više dovodi u pitanje njihova učinkovitost pri jednoobraznoj primjeni. Odjek ovakvog interdisciplinarnog istraživanja odnosi se na društvo u cjelosti. Pretilost je postala globalni problem,a niti jedna zemlja u posljednjih 33 godine nije uspjela preokrenuti ovaj negativni trend koji uzima veliki danak kroz sve veće izdatke u javnom zdravstvu. Istraživanje dinamike ravnoteže crijevnog mikrobioma s ciljem usmjeravanja prema željenom ishodu jedan je od najperspektivnijih smjerova u koji treba uložiti istraživačke napore da se pronađu odgovarajuća rješenja kako bismo ponudili što efikasniju terapiju ovom globalnom problemu.]]></summary_hr><summary_en><![CDATA[MicroEquilibrium aims to establish and maintain dynamic equilibrium of gut microbiota in vitro. Equilibrium is defined by positive covariance between ratios of Bacteroides, Prevotella and Ruminococcus observed in donor feces and in extracted biomass after fed-batch bioreactor cultivation. This in vitro model will be utilized to test hypothesis where introducing combinations of prebiotics and ortho-silicic acid in form of zeolites during cultivation can shift the observed equilibrium in targeted direction. Targeted direction is positively correlated with genus ratios observed in volunteers having healthy BMI span. Only an interdisciplinary approach which includes system biology,genomics,proteomics, bioinformatics,medicine,anthropology and mathematcial modelling can provide us with insights into dynamics of complex microbial communities existing in our guts. Using bioreactor model instead of volunteers is an attractive possibility which removes obstacles such as lack of control and ethical issues. Greatest benefit of planned research is the possibility to translate  results into personalized therapy for obesity which targets host mibrobiota equilibrium. The fact that the efficacy of this therapy is already tested in vitro is one step above current state-of-the-art in the field. Impact of this interdisciplinary research is great since it targets a major social, medical and economical problem. Obesity is one of the leading global problems. In the last 33 years not a single country has managed to turn this negative trend which is taking it&#39;s toll in terms of growing healthcare expenses. Since current research is questioning efficacy of generic treatment of systemic conditions such as obesity with drugs and probiotics, defining and exploring the dynamic equilibrium of microbiota is a perspective research direction. This direction requires a lot if effort and this project lowers threshold by going in vitro.]]></summary_en></project><project>
<id>4558</id><title_hr><![CDATA[Problemi u ponašanju djece školske dobi: Uloga izvršnih funkcija, individualnih, obiteljskih i genetskih čimbenika]]></title_hr><title_en><![CDATA[Problem behaviours in elementary school-aged children: The role of Executive funCtioning, individuL, familiAl, and geneTic factors ]]></title_en><user_id>2967</user_id><user_firstLast_name>Silvija Ručević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-3917</code><acronim><![CDATA[ECLAT]]></acronim><duration>10.01.2017 - 09.06.2021</duration><status>Završio</status><financ_value>46.006,37 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Psihologija, </scie_field_hr><scie_field_en>Psychology, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>2501, 2737, 20109, 12480, </team_members_id><team_members_names><![CDATA[Dino Krupić, Jasenka Wagner, Sandra Vučković, Tijana Borovac, ]]></team_members_names><keywords_hr><![CDATA[izvršne funkcije, MAOA, psihopatske tendencije, roditeljski postupci, rana iskustva, problemi u ponašanju, rizična ponašanja, longitudinalno]]></keywords_hr><keywords_en><![CDATA[executive functions, MAOA, psychopathic tendencies, parenting practecies, early experiences, problem behaviors, risky behaviors, longitudinal]]></keywords_en><summary_hr><![CDATA[Cilj istraživanja je ispitati učinke različitih čimbenika rizika iz različitih domena u razvoju problema u ponašanju djece osnovnoškolske dobi koristeći longitudinalni nacrt istraživanja. Ovo istraživanje se temelji na podacima slučajno odabranih 165 parova djece i roditelja iz 15 vrtića iz urbanog središta u Istočnoj Hrvatskoj. Podaci su prikupljeni u dvije točke mjerenja, s godinom dana razmaka (Pilot studija). Konkretno, prvi val (T1) Pilot studije proveden je između svibnja 2015. i veljače 2016. godine. Drugi val (T2) se trenutačno provodi. Djeca uključena u Pilot studiju su iz dvije dobne kohorte, (svibanj-prosinac) 2009. i (siječanj-svibanj) 2010, a oko polovice njih su dječaci (51%). Pilot studija će se koristiti kao prva dva vala sadašnjeg istraživanja.Sadašnje istraživanje imat će tri dodatna vala prikupljanja podataka, odnosno T3, T4 i T5. S obzirom na raspored istraživanja u Pilot studiji, T3, T4 i T5 bi trebali početi u svibnju 2017, svibnju 2018. i svibnju 2019. godine. U odnosu na Pilot istraživanje, sadašnje istraživanje će ispitati i učinke genetskih čimbenika (tj. MAOA) na probleme u ponašanju kod djece. Kako bismo postigli ovaj cilj radit ćemo u multidisciplinarnom timu (tri psihologa, pedagog i specijalist za genetiku).Koristeći se snagama longitudinalnog istraživanja, sadašnje istraživanje će ispitati učinke rizičnih/zaštitnih čimbenika na kasniji razvoj djeteta. Konkretno, ciljevi istraživanja su ispitati: (1) nezavisni doprinos i moderatorske/medijacijske učinke izvršnih funkcija, individualnih obilježja, roditeljskih postupaka, ranih iskustava, te genetskih čimbenika na objašnjenje problema u ponašanju djece školske dobi; (2) kratkoročnu i dugoročnu korisnost ispitivanih varijabli za predviđanje budućih socijalnih i ponašajnih ishoda kod djece, te (3) heterotipski kontinuitet ispitivanih varijabli tijekom prijelaza iz predškolske (Pilot studija) u školsku dob (sadašnje istraživanje), uzimajući u obzir homotipski kontinuitet.]]></summary_hr><summary_en><![CDATA[The aim of the study is to examine the effects of risk factors form multiple domains on problem behaviours in elementary school-aged children using a longitudinal research design. This study is based on the data collected from randomly selected 165 parent-child dyads from 15 kindergartens in a large urban area of eastern Croatia, in two successive assessments, one year apart (Baseline study). Specifically, the first wave (T1) of the Baseline study was conducted between May 2015-February 2016. The second wave (T2) is currently underway. Children included in the Baseline study are from two birth cohorts, (May-December) 2009 and (January-May) 2010, and about half of them are males (51%). The Baseline study will be used as two first waves of the Present study.The Present study will include three additional study waves, namely T3, T4 and T5. Based on the time table from the Baseline study, the T3, T4 and T4 should commence in May 2017, May 2018, and May 2019, respectively. Relative to the Baseline study, the present study will examine the effects of genetic factors (i.e., MAOA) on problem behaviours in children. To achieve this objective, we will have multidisciplinary team (three psychologists,specialist in development,specialist in genetics). Using the strengths of the longitudinal design, the Present study will investigate the effects of risk/protective factors on the later development of children. Specifically, the study will examine (1) independent contributions and moderating/mediating effects of executive functions, individual characteristics, parenting, early experiences, and genetic factors on problem behaviours in elementary school-aged children; (2) short and long-term utility of examined variables for predicting future social and behavioural outcomes in children; and (3) heterotypic continuity of examined variables during the transition from preschool (the Baseline study) to elementary school age (the Present study), taking into account homotypic continuity. ]]></summary_en></project><project>
<id>4559</id><title_hr><![CDATA[Od nusproizvoda u preradi žitarica i uljarica do funkcionalne hrane primjenom inovativnih procesa]]></title_hr><title_en><![CDATA[From Grain Byproducts to Functional Food through Innovative Processing]]></title_en><user_id>7661</user_id><user_firstLast_name>Duška Ćurić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-3789</code><acronim><![CDATA[GbP-FFood]]></acronim><duration>01.03.2017 - 29.02.2020</duration><status>Završio</status><financ_value>99.542,11 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Prehrambena tehnologija, Nutricionizam, </scie_field_hr><scie_field_en>Food technology, Nutrition, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Food Technology and Biotechnology]]></institution_en><team_members_id>19413, 19368, 13472, 13471, 12848, 19135, 19812, 13470, 19412, 6236, 20179, 11173, 25159, 25326, 26629, </team_members_id><team_members_names><![CDATA[Nikolina Čukelj, Dubravka Novotni, Dubravka Škevin, Klara Kraljic, Sandra Balbino, Saša Ajredini, Dražen Lušić, Marko Obranović, Bojana Voučko, Maja Benković, Marina Krpan, Mirjana Hruškar, Lidija Drobac, Matea  Habuš, Kristina Radoš, ]]></team_members_names><keywords_hr><![CDATA[nusproizvodi žitarica i uljarica, mikronizacija, ultrazvuk visokog intenziteta, enzimska hidroliza, nutritivni profil, funkcionalna hrana]]></keywords_hr><keywords_en><![CDATA[cereal and oilseed byproducts, micronization, high intensity ultrasound, enzimatic hydrolysis, nutritive profile, functional food]]></keywords_en><summary_hr><![CDATA[Suvremena prehrana je često nutritivno siromašna, a energetski bogata, što uzrokuje razne kronične bolesti. Unatoč tome, konvencionalna prerada biljnih kultura uobičajeno rezultira značajnom količinom nutritivno vrijednih nusproizvoda, kao što su posije žitarica i pogače uljarica, koje se uglavnom koriste kao stočna hrana. Primjenom spomenutih nusproizvoda u ljudskoj prehrani mogao bi se povećati unos vlakana, visokovrijednih proteina, esencijalnih masnih kiselina, mineralnih tvari, vitamina te raznih bioaktivnih spojeva koji mogu doprinijeti zdravlju. Jedan od razloga njihovog nedovoljnog iskorištenja u prehrani ljudi je slab interes potrošača, kao i narušena kvaliteta i trajnost prehrambenih proizvoda u koje se dodaju. Dodatno, upitna je i biološka iskoristivost navedenih nutrijenata, budući da se bioaktivni spojevi i mineralne tvari nalaze vezani u kompleksnim polimernim matriksima, a vlakna su većinom netopljiva.   Zbog svega navedenog se u okviru ovog projekta želi istražiti mogućnost maksimalnog iskorištenja makro- i mikronutrijenata te bioaktivnih sastojaka iz nusproizvoda mljevenja žitarica i proizvodnje ulja, uz osiguranje kvalitete krajnijih proizvoda. U tu svrhu provelo bi se fino usitnjavanje (10-30 µm) posija žitarica (pšenice, ječma, prosa i heljde) i pogača uljarica (buče, uljane repice, lana i sikavice) pri niskim temperaturama, obrada ultrazvukom visokog intenziteta te prirodna fermentacija sa ili bez dodatka enzima. Kombinacijom ovih tretmana očekuje se povećanje udjela slobodnih bioaktivnih spojeva te probavljivosti makro- i mikronutrijenata čime bi se moglo pospješiti njihovo djelovanje in vivo. Krajnji cilj projekta je optimizacija netoplinskih procesa obrade nusproizvoda žitarica i uljarica za dobivanje stabilnog i prehrambeno vrijednog materijala koji bi bio primjenjiv za obogaćivanje pekarskih i brašneno-konditorskih proizvoda i proizvoda namijenjenih osobama s posebnim prehrambenim potrebama.]]></summary_hr><summary_en><![CDATA[Modern diet is often based on nutritionally poor foods rich in energy, thus leading to different chronic diseases. Despite, conventional processing of plant foods results in significant amount of byproducts such as cereal bran and oilseed cakes, which are often used as an animal feed. Utilization of mentioned byproducts could result in increased daily intake of fibres, valuable proteins, essential fatty acids, minerals, vitamins, and different bioactive compounds, which can contribute to the human health. One reason of the insufficient utilization is low consumers interest, as well as impaired quality and shelf life of food products with added byproducts. Additionally, bioavailability of byproducts constituents is questionable, since bioactive compounds and minerals are mostly found in bound form in a complex polymer matrix, while fibres are mostly insoluble.  Thus, the aim of this project is the highest possible utilization of macro- and micronutrients and bioactive compounds from byproducts of industrial grain processing, together with preservation of the final products quality. For that reason, outer layers of cereal grains (wheat, barley, millet and buckwheat) and oilseed cakes (pumpkin seed, rapeseed, flax seed and milk thistle) will be milled to superfine particle size (10 – 30 µm), treated with high intensity ultrasound and spontaneously fermented with or without enzyme addition. The expected outcome of combined treatments is an increase of free bioactive compounds and digestibility of macro- and micronutrients, which could lead to their increased in vivo activity. Final goal of the project is optimisation of nonthermal processing of grain byproducts in order to obtain stable and nutritionally valuable material which can be used for enrichment of bakery and cereal based confectionary products and food for special dietary needs.   ]]></summary_en></project><project>
<id>4560</id><title_hr><![CDATA[Blaga repetitivna traumatska ozljeda mozga: model za istraživanje neuropatologije i neuroupale posredovane s TDP-43]]></title_hr><title_en><![CDATA[Mild repetitive traumatic brain injury: a model-system to study TDP-43-mediated neuropathology and neuroinflammation]]></title_en><user_id>20264</user_id><user_firstLast_name>Gordana Župan</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-4602</code><acronim><![CDATA[TDP-43repTBI]]></acronim><duration>01.06.2017 - 31.08.2021</duration><status>Završio</status><financ_value>129.072,93 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Medicine]]></institution_en><team_members_id>19186, 20286, 19750, 19848, 19752, 20292, 17173, 25435, </team_members_id><team_members_names><![CDATA[Kristina Pilipovic, Jasna Križ, Jelena Rajič, Tamara Janković, Petra Dolenec, Željko Župan, Jasenka Mršić-Pelčić, Nika Gržeta, ]]></team_members_names><keywords_hr><![CDATA[amiotrofična lateralna skleroza, frontotemporalna lobarna degeneracija, upala, repetitivna blaga traumatska ozljeda mozga, TDP-43, transgenični miš]]></keywords_hr><keywords_en><![CDATA[amyotrophic lateral sclerosis, frontotemporal lobar degeneration, inflammation, repetitive mild traumatic brain injury, TDP-43, transgenic mouse]]></keywords_en><summary_hr><![CDATA[Repetitivna blaga traumatska ozljeda mozga (engl. mild traumatic brain injury, mTBI) mogla bi biti povezana s proteinopatijom Tar DNA-vezujućeg proteina 43 (TDP-43) te klinički s razvojem kronične encefalopatije. Novija istraživanja ukazuju na prisutnost poremećaja u regulaciji TDP-43 u frontotemporalnoj lobarnoj degeneraciji (FTLD), amiotrofičnoj lateralnoj sklerozi (ALS) te drugim neurodegenerativnim poremećajima. Iako se repetitivna mTBI već dugo smatra čimbenikom rizika za pojavu demencija i ALS-a, patološka podloga još uvijek nije jasna. Prema novijim podatcima te našim preliminarni rezultatima, naša je hipoteza da repetitivna mTBI uzrokuje citosolno povećanje i agregaciju TDP-43 u središnjem živčanom sustavu (SŽS), što bi moglo biti uključeno u modulaciju dugotrajnog upalnog odgovora te posljedičnu neurodegeneraciju, a time i predispoziciju SŽS-a za razvoj FTLD/ALS. U ovom projektu koristit će se klinički relevantan model repetitivne mTBI. Radit će se testovi ponašanja, biokemijske i histološke metode, in vivo imaging te inovativne, stanično specifične, proteomske analize. Predloženi su sljedeći specifični ciljevi:1. Istražiti u kojoj je mjeri repetitivna mTBI povezana s disregulacijom TDP-43, neuroinflamacijom, neurodegeneracijom te razvojem TDP-43 posredovanih FTLD/ALS fenotipova u WT i TDP-43 transgeničnih miševa.2. Razviti sustav za in vivo imaging, koji će služiti za analize neuroinflamatornog odgovora izazvanog repetitivnom mTBI, u mišjem modelu, u realnom vremenu.3. Istražiti stanično-specifične molekularne karakteristike mikroglije nakon repetitivne mTBI u WT i TDP-43 transgeničnih miševa.Očekujemo da će rezultati ovog projekta omogućiti bolje razumijevanje patoloških promjena posredovanih TDP-43 i neuroinflamacijom u SŽS-u. Dodatno, jednom okarakteriziran mišji model za in vivo vizualizaciju mikroglioze u TBI/FTLD/ALS, bit će jedinstveno oruđe za analizu patologije te traženje meta za učinkovitu farmakoterapiju ovih bolesti.]]></summary_hr><summary_en><![CDATA[Repetitive mild traumatic brain injury (mTBI) may be associated with Tar DNA binding protein 43 (TDP-43) proteinopathy, and clinically with the development of chronic encephalopathy. Recent evidence suggests that TDP-43 disregulation has been identified also in frontotemporal lobar degeneration (FTLD), amyotrophic lateral sclerosis (ALS) and other neurodegenerative disorders. While repetitive mTBI has long been recognized as a risk factor for dementias and ALS, the underlying pathological mechanisms remain unclear. Based on some recent published evidence and our preliminary results, we hypothesize that repetitive mTBI induces cytosolic up-regulation/aggregation of TDP-43 in the CNS that may be involved in modulation of the long-lasting inflammatory response and consequent neurodegeneration thus predisposing CNS to develop FTLD/ALS. The clinically relevant model of repetitive mTB will be used. Behavioral, biochemical and histological methods, live imaging technique as well as innovative cell-type specific proteomic analyses will be performed. The following specific goals have been proposed: 1. To investigate to what extent the repetitive mTBI is associated with the deregulation of TDP-43, neuroinflammation, neurodegeneration and development of TDP-43 mediated FTLD/ALS phenotypes in WT mice and in the TDP-43 transgenic mice. 2. To develop in vivo model systems for real-time analysis of the repetitive mTBI-induced neuroinflammatory responses in biophotonic mouse model.  3. To investigate the microglial cells-specific molecular signatures after repetitive mTBI in WT and TDP-43 transgenic mice.   We expect that the results of this project will lead to better understanding of the TDP-43 and neuroinflammation mediated CNS pathology. Moreover, once characterized, the mouse model for live imaging of microgliosis in TBI/FTLD/ALS will represent unique tool for analysis of their in vivo pathology and efficient targeted drug screening. ]]></summary_en></project><project>
<id>4562</id><title_hr><![CDATA[Podrijetlo, ponašanje i modeliranje transporta nitrata u varaždinskom aluvijalnom vodonosniku]]></title_hr><title_en><![CDATA[Origin, fate and transport modelling of nitrate in the Varaždin alluvial aquifer]]></title_en><user_id>5844</user_id><user_firstLast_name>Tamara Marković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-5365</code><acronim><![CDATA[TRANITAL]]></acronim><duration>01.03.2017 - 28.02.2021</duration><status>Završio</status><financ_value>109.945,19 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Geologija, Kemija, Biologija, </scie_field_hr><scie_field_en>Geology, Chemistry, Biology, </scie_field_en><institution_hr><![CDATA[Hrvatski geološki institut]]></institution_hr><institution_en><![CDATA[Croatian Geological Survey]]></institution_en><team_members_id>5602, 3694, 19512, 19403, 19671, 19717, 19727, 19777, 6065, 23443, 25213, </team_members_id><team_members_names><![CDATA[Ozren Larva, Željka Brkić, Jasmina Martinčević Lazar, Marija Gligora Udovič, Renato Buljan, KREŠIMIR MALDINI, SIMANA MILOVIĆ, Marija Vrsalović, Martina Šparica Miko, Antonija Kulaš, Igor Karlović, ]]></team_members_names><keywords_hr><![CDATA[nitrat, kakvoća podzemne vode, stabilni izotopi, model transporta, aluvijalni vodonosnik]]></keywords_hr><keywords_en><![CDATA[nitrate, groundwater quality, stable isotopes, transport model, alluvial aquifer]]></keywords_en><summary_hr><![CDATA[Nitrat je spoj dušika koji se javlja u prirodni te se pojavljuje u umjerenim koncentracijama u brojnim vodenim sustavima. Visoke koncentracije nitrata su posljedica antropogene aktivnosti. Visoke koncentracije nitrata pojavljuju se u aluvijalnom vodonosniku na području grada Varaždina. Područje istraživanja zahvaća slivna područja crpilišta &#39;&#39;Varaždin&#39;&#39; i &#39;&#39;Vinokoščak&#39;&#39;. Istraživanja koja su provedene na području istraživanja s obzirom na probleme nitrata, su ili iz hidrogeološkog ili poljoprivrednog gledišta. Na području istraživanja nikada nije provedeno sustavno interdisciplinarno istraživanje ponašanja i raspodjele nitrata u vodonosniku koje bi uključivalo različite istraživače iz različitih disciplina, te različite tehnike istraživanja denitrifikacijskih i nitrifikacijskih procesa u vodonosnom sustavu. Šest je glavnih ciljeva TRANITAL projekta:1. Razviti multi-parameterski pristup za određivanje značajki aluvijalnog vodonosnika pomoću hidrauličkih, kemijskih, isotopnih i mikrobioloških pokazatelja2. Odrediti ulogu površinskih voda na napajanje/dreniranje aluvijalnog vodonosnika i njihov utjecaj na koncentraciju dušika u aluvijalnom vodonosniku3. Odrediti mineraloška i kemijska svojstva tla i njegov utjecaj na dušikov ciklus4. Određivanje podrijetla nitrata i procesa koji mogu dovesti do poboljšanja kakvoće podzemne vode5. Načiniti model toka podzemne vode i transporta nitrata u aluvijalnom vodonosniku6. Prenijeti spoznaje o podrijetlu, ponašanju i transportu nitrata u aluvijalnom vodonosnikuGlavni cilj TRANITAL projekta je osigurati znanstveno opravdani pristup i prijenos znanja između znanstvenika iz različitih disciplina koji će istraživati vodonosnike čija je kakvoća narušena zbog visokih koncentracija nitrata te prenijeti znanje upravi, planerima, vodnim grupacijama na lokalnoj i državnoj razini kako bi se osiguralo ekološko održivo upravljanje vodnim resursima i poljoprivrednom proizvodnjom.]]></summary_hr><summary_en><![CDATA[Nitrate is a compound of nitrogen that occurs naturally in moderate concentrations in many aquatic environments. Higher concentrations of nitrate in groundwater are typically caused by anthropogenic activities. High nitrate content is in groundwater of the surrounding area of the town Varaždin. The research area compromise the catchment area of the pumping sites ‘’Varaždin’’ and ‘’Vinokoščak’’. The studies that have been conducted in the research area considering the nitrate problems are from hydrogeological or agricultural point of view. In the research area there were never conducted systematic interdisciplinary research on fate and distribution of nitrate in the aquifer which would include different type of researchers, different techniques of studying denitrification and nitrification processes in the system such as aquifer. There are 6 main objectives in TRANITAL project:1.	To developed multi-parametric approach to characterize alluvial aquifer hydraulic properties and groundwater chemical, isotopic and microbiological properties. 2.	To define the role of surface waters on aquifer recharge and nitrogen cycle. 3.	To define the soil’s mineral and chemical and microbiological properties and its role in nitrogen cycle. 4.	To identify the sources of nitrate that causes the groundwater deterioration and the processes that may assist in groundwater natural attenuation. 5.	To create flow and nitrate transport numerical model of the alluvial aquifer. 6.	Transfer of knowledge about nitrate origin, fate and transport in the alluvial aquifer. The main goal of the TRANITAL project is to provide scientifically justified approach and transfer of knowledge between scientists of different disciplines which will study aquifers with high nitrate concentrations which deteriorate groundwater quality and to transfer the knowledge to decision makers and local water-use groups to ensure environmentally sustainable management of water resources and agricultural production.]]></summary_en></project><project>
<id>4571</id><title_hr><![CDATA[Primjena proteinskih hidrolizata iz pogača lana i konoplje u medijima za uzgoj životinjskih stanica]]></title_hr><title_en><![CDATA[Application of protein hydrolysates from flaxseed and hempseed oil cakes as animal cell culture media supplement]]></title_en><user_id>5279</user_id><user_firstLast_name>Višnja Gaurina Srček</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-3848</code><acronim><![CDATA[HYDRO PEP CELL]]></acronim><duration>01.03.2017 - 31.05.2021</duration><status>Završio</status><financ_value>106.943,43 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Biotehnologija, </scie_field_hr><scie_field_en>Biotechnology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Food Technology and Biotechnology]]></institution_en><team_members_id>3228, 796, 19708, 5443, 797, 6126, 25193, </team_members_id><team_members_names><![CDATA[Ivana Radojčić Redovniković, Jasna Beganović (udana Novak od 23. svibnja 2015.), Igor Slivac, Kristina  Radošević, Andreja Leboš Pavunc, Marina Cvjetko Bubalo, Marijan Logarušić, ]]></team_members_names><keywords_hr><![CDATA[uljne pogače, hidrolizati proteina, kultura životinjskih stanica, medij za uzgoj, CHO stanice]]></keywords_hr><keywords_en><![CDATA[oil cake, protein hydrolysates, animal cell culture, culture media, CHO cells]]></keywords_en><summary_hr><![CDATA[Kulture životinjskih stanica koriste se za proizvodnju visokovrijednih spojeva kao što su rekombinantni proteini. Za uspješan rast, održavanje i produktivnost kultura stanica potreban je medij za uzgoj koji mora sadržavati hranjive tvari, soli, hormone, faktore rasta te serum životinjskog porijekla. Posljednjih desetljeća uočeni su problemi primjene seruma u procesima s kulturama stanica, a koji se očituju u rizicima prijenosa virusa, priona i mikoplazmi te otežanoj izolaciji proizvoda. U cilju prevladavanja nedostataka primjene seruma razvijeni mediji bez seruma koji često sadrže hidrolizate biljnog porijekla. Hidrolizati sadrže aminokiseline, oligopeptide, lipide, vitamine i ostale spojeve koji potiču proliferaciju i produktivnost stanica u kulturi.Nus-proizvodi prehrambene industrije, a među njima i ostaci iz proizvodnje jestivog ulja tzv. pogače, zbog značajnog sadržaja proteina predstavljaju novu potencijalnu sirovinu za primjenu u tehnologiji životinjskih stanica. Pogače lana i industrijske konoplje sadrže 30-35% proteina i kao takve nisu zanemariv izvor proteina koji se može koristiti kao dodatak u medijima za uzgoj životinjskih stanica. Glavni cilj predloženog Projekta jest primjena proteinskih hidrolizata pripravljenih iz pogača lana i konoplje kao dodatka medijima za uzgoj stanica (s i bez seruma). Istražit će se učinak hidrolizata na prinos proizvoda biotehnološkog postupka proizvodnje rekombinantnih proteina obzirom na proliferaciju stanica i proizvodnost. Ukoliko predložena istraživanja budu provedena, rezultati dobiveni ovim Projektom doprinijet će većem ekonomskom iskorištenju nus-proizvoda iz proizvodnje ulja lana i konoplje. Štoviše, u slučaju pozitivnog učinka hidrolizata na rast stanica i proizvodnost rekombinantnih proteina, razvijeni postupak hidrolize te strategija prihranjivanja hidrolizatima tijekom uzgoja stanica, doprinijet će tehnologiji životinjskih stanica na način da će utjecati na oblikovanje medija bez seruma. ]]></summary_hr><summary_en><![CDATA[Animal cell culture has a great importance in production of recombinant proteins. For successful maintenance of animal cell culture, it is essential to ensure culture medium which consists of various nutrients and a blood serum of animal origin. However, the addition of animal sera has always been related to complex isolation of the cell product. Therefore, in order to overcome the obstacles of serum addition, cell culture experts developed serum-free media that still show better performance with addition of protein hydrolysates, preferably of plant origin. Plant hydrolysates are reach source of peptides and amino acids as well as other growth stimulating factors. One of the most promising substances for making these hydrolysates are protein rich by-products of edible oil industry called oil cakes or oil meals. Oil-cakes of flax and industrial hemp seeds contain 30-35% proteins, and as such can be used as a nutritious media supplement for animal cell cultivation. The main objective of the proposed project is to determine the effects of flaxseed and hempseed oil cake hydrolysates on cell proliferation and recombinant protein production. We want to carry out an enzyme based oil cake hydrolysis and apply different hydrolysate fractions and concentrations in cell culture, with or without serum. Defining the parameters of hydrolysis and characterization of derived peptides is the foundation for standardization of the hydrolysate composition and their administration as nutritive supplements for cell culture. The results obtained with this project will contribute to the re-evaluation of waste-products from flax and hemp oil industry and direct their application in the field of animal technology. If positive results were achieved, (i.e. hydrolysates show stimulatory effects on cell growth and productivity), the selected hydrolysate fractions could be used as a beneficial culture media component and thus affect future media formulations.]]></summary_en></project><project>
<id>4572</id><title_hr><![CDATA[Prototip višenamjenskog kompozitnog panela drvo – nosivo staklo]]></title_hr><title_en><![CDATA[Prototype of multipurpose timber - structural glass composite panel]]></title_en><user_id>19348</user_id><user_firstLast_name>Vlatka Rajčić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-3811</code><acronim><![CDATA[VETROLIGNUM]]></acronim><duration>01.03.2017 - 29.02.2020</duration><status>Završio</status><financ_value>99.455,84 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Građevinarstvo, Arhitektura i urbanizam, </scie_field_hr><scie_field_en>Civil engineering, Architecture and Urban Environment, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Građevinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Civil Engineering]]></institution_en><team_members_id>19909, 20254, 20244, 20363, 21350, 369, 21359, 21354, 21365, 21363, 21377, </team_members_id><team_members_names><![CDATA[Mislav Stepinac, Roko Žarnić, Jure Barbalić, Adriana Bjelanović, Ivan Ćurković, Davor Skejić, Ivica Plavec, Valentina Frighi, Roberto Di Giulio, Silvia Brunoro, Meta Kržan, ]]></team_members_names><keywords_hr><![CDATA[staklo, drvo, potres, kompoziti, prototip]]></keywords_hr><keywords_en><![CDATA[glass, timber, earthquake, composites, prototype]]></keywords_en><summary_hr><![CDATA[U posljednjih nekoliko desetljeća došlo je do naglog razvoja stakla kao nosivog materijala. S druge strane, povećanje primjene stakla djelomično je ograničeno jer ne postoje dostupni i odgovarajući propisi koji bi projektantima i izvođačima omogućili širu primjenu stakla. Nosivo staklo u kombinaciji s drvenim okvirom predstavlja kompozitni sustav koji ima predispozicije za dobro ponašanje prilikom potresa, istovremeno je energetski efikasno i isplativo, estetski prihvatljivo te ima dobre nosive karakteristike. U novije vrijeme provedeno je nekoliko istraživanja kompozitnih sustava drvo – nosivo staklo pri monotonim i cikličkim ispitivanjima koja su nužna kako bi kompoziti bili ugradljivi u potresno aktivnim zonama. U projektu će se ispitati ne samo nosiva svojstva panela već i energetska efikasnost cjelokupnog sustava.]]></summary_hr><summary_en><![CDATA[In recent decades there has been a rapid development of glass as a load-bearing material. The increase in the application of glass is partially limited because of the lack of available and appropriate regulations and standards. Structural glass combined with a timber frame is a composite system that has a predisposition for good behavior during an earthquake, it is energy-efficient and cost-effective, aesthetically acceptable and has a good load-bearing characteristics. In recent years, several research projects of composite systems timber - structural glass are in progress. Monotonous and cyclic tests are necessary for composites which will be used in earthquake prone zones. In the project both load bearing and energy efficiency properties of the panel will be tested and the behavior of the panels will be characterized in detail.]]></summary_en></project><project>
<id>4593</id><title_hr><![CDATA[Učinci ekonomskih katastrofa]]></title_hr><title_en><![CDATA[Effects of Economic Disasters]]></title_en><user_id>19176</user_id><user_firstLast_name>Bruno Ćorić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-4682</code><acronim><![CDATA[ECONDIS2016]]></acronim><duration>01.01.2017 - 31.12.2019</duration><status>Završio</status><financ_value>41.629,97 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, </scie_field_hr><scie_field_en>Economy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Ekonomski fakultet]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Economics, Business and Tourism]]></institution_en><team_members_id>19207, 12620, </team_members_id><team_members_names><![CDATA[Vladimir Šimić, Vinko Muštra, ]]></team_members_names><keywords_hr><![CDATA[ekonomske katastrofe, rast outputa, volatilnost outputa, investicije, transmisijski kanali, institucije]]></keywords_hr><keywords_en><![CDATA[economic disasters, output growth, output volatility, investment, transmission mechanisms, institutions]]></keywords_en><summary_hr><![CDATA[Kolaps na tržištu hipotekarnih kredita u ljeto 2007. godine u SAD-u izazvao je jednu od najtežih financijskih i ekonomskih kriza u novijoj povijesti, odnosno prvu globalnu krizu nakon Drugog svjetskog rata. Navedeni događaji pružili su poticaj razvoju pravca u ekonomskoj literaturi usmjerenom na promatranje utjecaja velikih ekonomskih kriza, takozvanih ekonomskih katastrofa. Nakon iznimno važnog istraživanja Barro-a (2006) fokus većine istraživanja je bio usmjeren na moguće učinke ekonomskih katastrofa na cijene financijske imovine i financijska tržišta. Naš prijedlog istraživanja, s druge strane, usredotočuje se na učinke ekonomske katastrofe na realni sektor gospodarstva. To je područje koje je ostalo uglavnom neistraženo u recentnoj literaturi o ekonomskim katastrofama.Naše istraživanje ima tri glavna cilja. U prvom redu istraživanje će sadržavati istragu povezanosti ekonomskih katastrofa i volatilnosti outputa. Preciznije, naš cilj je istražiti promjene u volatilnosti outputa u posljednja dva stoljeća i detektiranje mogućih objašnjenja tih promjena s posebnim osvrtom na ulogu ekonomskih katastrofa. Naš drugi cilj se odnosi na istraživanje dugoročnih učinaka ekonomskih katastrofa na stopu rasta outputa. Fokus je na istraživanju dugoročnih posljedica ekonomske katastrofe na stopu rasta outputa; moguće transmisijske kanale kroz koje ekonomske katastrofe mogu utjecati na rast outputa i ulogu institucija u ekonomskim katastrofama i njihovim dugoročnim učincima. Treći dio ovog istraživanja će se fokusirati na ulogu ekonomske katastrofe u gospodarskoj povijesti Hrvatske. Naš cilj je istražiti ekonomske katastrofe zabilježene u gospodarskoj povijesti Hrvatske; moguće dugoročne učinke ovih ekonomskih katastrofa na stopu rasta outputa i volatilnost outputa; analiziranje i predviđanje mogućih negativnih dugoročnih posljedica sadašnje krize i predlaganje mjera za sprečavanje ili ublažavanje tih negativnih posljedica.]]></summary_hr><summary_en><![CDATA[The collapse of the subprime mortgages market in the summer of 2007 in US triggered one of the most severe financial and economic crises in recent history and the first global economic downturn after the Second World War. These events give impetus to the new literature on the effects of large economic crises, the so called economic disasters. Following groundbreaking Barro’s (2006) study most of these researches focus on the possible effects of economic disasters on asset pricing and financial markets. Our research proposal, on the other hand, focuses on the effects of economic disasters on the real sector of economy. This is the area that has remained largely uninvestigated by the recent literature on economic disasters. 	Our research has three main goals. The first line of enquiry will comprise an investigation of the relationship between economic disasters and output volatility. In particular, our goal is to investigate changes in output volatility over the last two centuries and to provide possible explanation(s) for these changes with a special reference to the role of economic disasters. Our second line of enquiry will include an investigation of the long-run effects of economic disasters on output growth. The goal is to investigate the long-run effects of economic disasters on output growth; the possible transmission channels through which economic disasters can affect output growth, and the role of institutions in economic disasters and their long-run effects. The third part of this research is going to focus on the role of economic disasters in Croatian economic history. Our goal is to investigate economic disasters in the recorded economic history of Croatia; the possible long-run effects of these economic disasters on output growth and output volatility; to analyze and predict possible negative long-run effects of current crisis and suggest policy measures for prevention or amelioration of these negative consequences.]]></summary_en></project><project>
<id>4595</id><title_hr><![CDATA[Politike identiteta i hrvatska drama od 1990. do 2016.]]></title_hr><title_en><![CDATA[Identity Politics and Croatian Drama from 1990 to 2016]]></title_en><user_id>13758</user_id><user_firstLast_name>Zlatko Kramarić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-4316</code><acronim><![CDATA[PoIHDrama]]></acronim><duration>01.04.2017 - 31.03.2021</duration><status>U tijeku</status><financ_value>70.151,97 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filologija, Znanost o umjetnosti, </scie_field_hr><scie_field_en>Philology, Arts, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Građevinski i arhitektonski fakultet Osijek]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Civil Engineering and Architecture Osijek]]></institution_en><team_members_id>13740, 19293, 13737, 19561, 13752, 19633, </team_members_id><team_members_names><![CDATA[Lucija Ljubić, Martina Petranović, Ivan Trojan, Višnja Kačić Rogošić, Ivana Žužul, Kristina Peternai Andrić , ]]></team_members_names><keywords_hr><![CDATA[politike identiteta, hrvatska drama, hrvatsko kazalište, književna historiografija, kazališna historiografija]]></keywords_hr><keywords_en><![CDATA[identity politics, Croatian drama, Croatian theatre, literary historiography, theatre historiography]]></keywords_en><summary_hr><![CDATA[Budući da se hrvatskoj drami nastaloj od 1990. do 2016. zasad pristupalo parcijalno i većinom iz vizure jedne istraživačke osobnosti, projektnim prijedlogom Politike identiteta i hrvatska drama od 1990. do 2016. obuhvatit će se cjelovit dramski korpus navedenog razdoblja, a predmet istraživanja proširit će se analizom teksta nastalog tijekom rada na predstavi ili na samoj izvedbi u okviru samostalnih autorskih ili kolektivnih kazališnih predstava. Projektni prijedlog teorijsko-metodološki počiva na rodnim studijima i antiesencijalističkim teorijama nacije, a termin politike identiteta preuzet je iz recentnih proučavanja identiteta utemeljenih na izvođenju pojma razlike u poststrukturalizmu i dekonstruiranju esencijalističkog pristupa pojmu u kojem je identitet reprezentiran kao nedjeljiv, neproblematičan i prirodan. Istraživanje polazi od pretpostavke da kazališne, književne, kazališnopovijesne i književnopovijesne reprezentacije te druge narativne konstrukcije navedenog dramskog korpusa imaju važne implikacije u samoprepoznavanju i oblikovanju vlastitog nacionalnog identiteta i zato su u središtu interesa odnosi rodnog i nacionalnog identiteta, ali i drugih kolektivnih identiteta. Analizirat će se i institucionalni okviri unutar kojih nastaje i opstaje hrvatska drama, odnos hrvatske drame i kazališta, međunarodna recepcija i medijska slika hrvatske drame te učinci prešutnih naknadnih književnohistoriografskih i kazališnohistoriografskih teorijskih sudova i konstrukata koji skrivaju institucionalne napukline kanona književnosti i kazališta kao i bilo kojeg drugog identiteta. ]]></summary_hr><summary_en><![CDATA[Since the Croatian drama produced from 1990 to 2016 has been approached partially and mostly from a perspective of a singular researcher persona, the project proposal Identity Politics and Croatian Drama from 1990 to 2016 will encompass a comprehensive dramatic corpus of the adduced period, whereby the research topic will be expanded by an analysis of the text produced while working on a show or at a performance itself within the auctorial or collective theatrical performances. Theoretically and methodologically, the project proposal relies on gender studies and anti-essentialist nation theories, and the identity politics term is assumed from the recent identity studies based on a derivation of a notion of difference in poststructuralism and in a deconstruction of an essentialist approach to the term, in which identity is represented as inseparable, unproblematic, and natural. The research starts from a hypothesis that the theatrical, literary, theatrical-historical and historico-literary representations and other narrative constructions of the aforementioned dramatic corpus exert significant implications in a self-recognition and formulation of a proper national identity, because of which the relationships between a gender-based and national identity, as well as of other collective identities, are in the center of interest. The institutional frameworks within which the Croatian drama is being produced and sustained, a relationship between the drama and theatre, an international reception and a media picture of the Croatian drama, and the effects of the tacit subsequent literary-historiographic and theatrical-historiographic theoretical judgments and constructs that conceal the institutional flaws in the canons of literature and theatre and any other identity, will also be analyzed. ]]></summary_en></project><project>
<id>4600</id><title_hr><![CDATA[Inovativne tehnike u minimalnoj preradi krumpira (Solanum tuberosum) i njegova zdravstvena ispravnost nakon pripreme]]></title_hr><title_en><![CDATA[Innovative techniques in potato minimal processing (Solanum tuberosum) and its safety after preparation]]></title_en><user_id>2644</user_id><user_firstLast_name>Branka Levaj</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-5343</code><acronim><![CDATA[IMPROvePOTATO]]></acronim><duration>01.03.2017 - 30.06.2021</duration><status>Završio</status><financ_value>126.219,39 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Prehrambena tehnologija, </scie_field_hr><scie_field_en>Food technology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Food Technology and Biotechnology]]></institution_en><team_members_id>19066, 12848, 1062, 19143, 1330, 13351, 20284, 20040, 20300, 25271, 25824, </team_members_id><team_members_names><![CDATA[Kata Galić, Sandra Balbino, Sandra Pedisić, Mario  Ščetar, Maja Repajić, Filip Dujmić, Sanja Loncaric, Draženka Dite, Milan Poljak, Zdenka Pelaić, Zrinka Čošić, ]]></team_members_names><keywords_hr><![CDATA[minimalno prerađeni krumpir, visoki hidrostatski tlak, ultraljubičasto svjetlo, ultrazvuk , akrilamid, piliciklički aromatski ugljikovodici]]></keywords_hr><keywords_en><![CDATA[minimally processed potatoes, high hydrostatic pressure, ultraviolet light, ultrasound, acrylamide, polycyclic aromatic hydrocarbons]]></keywords_en><summary_hr><![CDATA[Krumpir (Solanum tuberosum) je široko raspstranjeno povrće, vrlo često u prehrani ljudi, prikladno za skladištenje u neprerađenom stanju i do jedne godine. Kompleksnog je kemijskog sastava podložnog promjenama ovisno o uvjetima i duljini skladištenja. Priprema se za jelo na različite načine pri čemu, također, dolazi do određenih poželjnih i nepoželjnih promjena u kemijskom sastavu. U Hrvatskoj se krumpir većinom plasira na tržište neprerađeni ili u manjoj mjeri prerađen u čips i sl. snack proizvode. U drugim zemljama prerada krumpira je u porastu pri čemu minimalno prerađeni krumpir - MPK (oguljen, opran, narezan, zapakiran, toplinski neobrađen) postaje sve traženiji. Iako vrlo praktičan, takav proizvod je kratkog vijeka trajanja (uobičajeno 7 dana) i sklon je posmeđivanju te je vrlo zahtjevan za proizvodnju i čuvanje (pri temperaturi ne višoj od 8oC). Cilj ovog projekta je stjecanje spoznaja koje bi pomogle u proizvodnji MPK. Konkretnije stjecanje znanja o kemijskom sastavu različitih sorata krumpira i njegovim promjenama tijekom skladištenja te o načinima sprječavanja enzimskog posmeđivanja narezanog krumpira, stjecanju spoznaja o mogućim utjecajima na održavanje poželjnog kemijskog sastava u cilju smanjenja nastanka nepoželjnog akrilamida usljed prženja i pečenja krumpira te o načinu provedbe prženja da udjel policikličkih aromatskih ugljikovodika koji putem ulja dospijevaju u prženi krumpir bude minimalan. Nadalje, cilj je stjecanje spoznaja o utjecaju netoplinskih tehnologija (ultrazvuka visokog intenziteta - UZV, visokog hidrostatskog pritiska - HHP i ultraljubičastvog svjetla - UV-C) na kemijski sastav i posljedično na stabilnost MPK pri različitim uvjetima čuvanja. Konačni cilj je optimiranje proizvodnje MPK što uključuje definiranje optimalne sorte, postupka za sprječavanje posmeđivanja (s ili bez UZV), ambalaže i uvjeta pakiranja, te primjene netoplinskih tretmana (HHP i UV-C) u svrhu produljenja trajnosti te mogućnosti čuvanja pri sobnoj temperaturi.]]></summary_hr><summary_en><![CDATA[Potato (Solanum tuberosum) is a widespread vegetable, often used in human diet, suitable for storage as unprocessed up to one year. It has a complex chemical composition susceptible to changes depending on the conditions and duration of storage. It could be prepared for consumption in many ways by which favorable or unfavorable changes in the chemical composition also occur. In Croatia, the majority of potatoes is marketed unprocessed or, to a lesser extent, processed as chips and similar snacks. In other countries, processing of potatoes is increasing with minimally processed potatoes - MPP (peeled, washed, sliced, packaged, untreated by heat) becoming more popular. Although very convenient, such product has short shelf life (usually 7 days), is susceptible to browning and very demanding for production and storage (at temperature lower than 8 °C). The aim of this project is to acquire knowledge that would help in the production of MPP, specifically on the chemical composition of different potato varieties, their changes during storage and preventing enzymatic browning of sliced potatoes. It will also deal with the effects for guarding suitable chemical composition in order to reduce the formation of undesired acrylamide, a result of potatoes frying and baking, and with the frying method that would minimize the level of polycyclic aromatic hydrocarbons from oil in the fried potatoes. Furthermore, the goal is to acquire knowledge about the impact of non-thermal technologies (high intensity ultrasound, high hydrostatic pressure and ultraviolet light) on the chemical composition and consequently the stability of the MPP at different storage conditions. The main goal is to optimize the manufacture of MPP including the selection of the optimal variety, the procedure to prevent browning, the packaging and the packaging conditions and the application of non-thermal treatment in order to prolong durability and make possible storage at room temperature.]]></summary_en></project><project>
<id>4603</id><title_hr><![CDATA[Novel Characterizations of Classical and Quantum Many-Body Systems]]></title_hr><title_en><![CDATA[Novel Characterizations of Classical and Quantum Many-Body Systems]]></title_en><user_id>20277</user_id><user_firstLast_name>Fabio Franchini</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-3347</code><acronim><![CDATA[ManyBodyCharacteriza]]></acronim><duration>01.05.2017 - 31.08.2021</duration><status>Završio</status><financ_value>129.006,57 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>6532, 11143, 25292, 28968, 28967, 28970, 26810, 29625, </team_members_id><team_members_names><![CDATA[Ivan Balog, Vinko Zlatić, Vanja Marić, Andrei Fedorenko, Domagoj Kuić, Luka Sinković, Salvatore Marco Giampaolo, Jovan Odavić, ]]></team_members_names><keywords_hr><![CDATA[mnogočestični sustavi, nered, lokalizacija, lavine, Isingov model u nasumičnom polju, neperturbativna renormalizacijska grupa, kvantno sprezanje]]></keywords_hr><keywords_en><![CDATA[Many-body systems, Disorder, Localization, Avalanches, Random Field Ising Model, Non-perturbative Renormalization Group, Entanglement]]></keywords_en><summary_hr><![CDATA[Više je različito napisao je P.W.Anderson godine 1972, objašnjavajući kako je glavni izazov moderne fizike razumjeti i opisati kako interakcija velikog broja elemenata dovodi do novih i kompleksnih ponašanja, koji se ne mogu objasniti preko ponašanja izvornih konstituenata.   Kako bismo identificirali najbolje varijable i pristupe nekoliko prototipskih modela, skupili smo stručnjake iz raznih aspekata kompleksih sustava.Koristit ćemo jednostavni model sa specifičnim svojstvima, kako bismo razumjeli odnos između novootkrivene vrste spontanog loma simetrije, lokalizacije i staklastog ponašanja, s primjenama u fizici čvrstog stanja i kompleksnih sustava (a možda i teoriji struna). Ovaj model je formuliran u preko članova velike matrice i već je prije povezan s metal/izolator prijelazom i Chern-Simons/topološkim teorijama struna. Nedavno je otkriveno kako je netrivijalni spontani lom simetrije koji se javlja u tom modelu odraz vrlo složenog energetskog krajolika, kojeg karakterizira parametarski velik broj ravnotežnih konfiguracija (sedla particijske funkcije). Takvo ponašanje je primjer kompleksnog sustava i može ga se opisati tim movim tipom loma simetrije.Paralelno tome istražiti ćemo jednodimenzionalni model s dugodosežnim interakcijama, kako bismo modelirali ponašanje Isingovog modela u nasumičnom polju i proučili critično ponašanje s naglaskom na fenomenologiju lavina. U ovom modelu efektivna dimenzija je enkodirana u parametru dosega interakcija, što nam dozvoljava prilagođavanje necjelobrojnoj dimenziji u kojoj se događa ponašanje koje nam je interesantno.Također ćemo se baviti jako interagirajućim kvantnim sustavima i njihovim svojstvima kvantnog sprezanja, kako bismo shvatili način na koji informacijska teorija može pomoći u razaznavanju specijalne prirode multi-kritičnih, ne-konformnih točaka. Kvantno sprezanje je suštinski povezano s kvantnim računanjem i koristit ćemo novu veličinu, koja se zove nelokalna konvertibilnost.]]></summary_hr><summary_en><![CDATA[More is Different wrote P.W. Anderson in 1972, explaining that the central challenge of modern physics is to understand how the interaction of a large number of elementary constituents can lead to the emergence of novel, complex behaviors, which can hardly be explained in terms of the original ingredients.In order to identify the appropriate variables and formalism to capture the behavior of a few prototypical toy models, we will assemble expertise in different types of complex systems.On one side, we will use a toy model understand the relation between a novel spontaneous symmetry breaking (SSB), localization and glassiness, with applications in condensed matter and complex systems. This model is formulated in terms of large matrices and has already been linked to the metal/insulator transition from one side, and to the Chern-Simons/topological string theories from another. More recently, it was understood that the conjectured nontrivial SSB realized in this model is the reflection of a complex energy landscape, characterized by a parametrically large number of equilibrium. Such a behavior is paradigmatic of a complex system and thus it can be captured by a new type of replica symmetry breaking.In a parallel effort, we will use a one dimensional model with long range interaction as a tool to model the behavior of the random field Ising model in different dimensions and to study the critical exponents and avalanche phenomenology. In the toy model, the effective dimension is encoded in decay rate of the long range interaction and thus allow for a fine tuning even to relevant “fractional” dimensions emerging from non-perturbative-RG.We will also tackle strongly interacting quantum systems and their entanglement properties, to understand how information theory can help in discriminating the special nature of multi-critical, non-conformal points and the computational power of topological phases through non-local convertibility.]]></summary_en></project><project>
<id>4608</id><title_hr><![CDATA[Ciljana izrada prototipa vlaknastog nosača za uzgoj tkivnih stanica kombiniranim elektroispredanjem]]></title_hr><title_en><![CDATA[Custom Tailored Fibrous Scaffold Prototype for Tissue Cells Culture via Combined Electrospinning]]></title_en><user_id>443</user_id><user_firstLast_name>BUDIMIR MIJOVIĆ</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-6878</code><acronim><![CDATA[COMBOELECTROSPUN]]></acronim><duration>01.03.2017 - 31.08.2021</duration><status>Završio</status><financ_value>128.701,43 eur</financ_value><scie_area_hr>Tehničke znanosti, Biotehničke znanosti, </scie_area_hr><scie_area_en>Technological sciences, Biotechnical sciences, </scie_area_en><scie_field_hr>Tekstilna tehnologija, Kemijsko inženjerstvo, Strojarstvo, Biotehnologija, </scie_field_hr><scie_field_en>Textile technology, Chemical engineering, Mechnical engineering, Biotechnology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Tekstilno-tehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Textile Technology]]></institution_en><team_members_id>19773, 826, 4848, 3644, 7628, 20048, 5286, 6487, 19708, </team_members_id><team_members_names><![CDATA[Emi Govorčin Bajsić, Tamara Holjevac Grgurić, Mirna Tominac Trcin, Emilija Zdraveva, Tamara Dolenec, Ivana Vrgoč, Iva Dekaris, Xungai Wang, Igor Slivac, ]]></team_members_names><keywords_hr><![CDATA[elektroispredanje, nosači, antibakterijsko svojstvo, faktor rasta, stanice]]></keywords_hr><keywords_en><![CDATA[electrospinning, scaffolds, antibacterial property, grow factor, cells]]></keywords_en><summary_hr><![CDATA[Glavni cilj ovog interdisciplinarnog projekta je ciljani razvoj prototipa vlaknastog nosača za uzgoj tkivnih stanica, temeljen na tekstilnoj tehnici elektroispredanja. Veliki izazov u elektroispredanju nosača je potreba za strukturom s porama dovoljno velikog promjera (makro skala) kako bi se olakšalo prodiranje stanica i vlaknima dovoljno malog promjera (nano skala) kako bi oponašali prirodno izvanstanično okruženje. Jedinstveni doprinos ovog projektnog prijedloga temelji se na kombinaciji dviju tehnika elektroispredanja. Elektroispredanje iz otopine i taline će se koristiti za izradu nosača kombiniranih nanovlaknastih i mikrovlaknastih slojeva. Površinska adhezija stanica biti će dodatno poboljšana s izradom ciljane topografije površine nosača, pripremljene elektroispredanjem na metalnim kolektorima s ciljanom poroznošću. Drugi aspekt je izrada nosača ciljanih funkcija, uključujući antibakterijsko svojstvo i svojstvo stimulacije staničnih procesa pomoću bioloških komponenti. Konačni cilj projekta je odabrati nosače s optimalnom strukturom i multifunkcionalnošću. Multifunkcionalnost nosača će se temeljiti na sustavnom istraživanju s ciljem definiranja  optimalnih uvjeta za posjedovanje antibakterijskih svojstava i svojstava kontroliranog oslobađanja biološke komponente. Predloženi materijali za izradu nosača su polikaprolakton i poliuretan kao matrice u kombinaciji s fibroinom svile za dodatno poboljšanje površinske adhezije stanica. Nosači će biti sustavno istraživani i u smislu mehaničkih svojstava, kako bi ispunili konstrukcijske zahtjeve za čvrstoću, a to je da se mogu oduprijeti opterećenjima nastalim uslijed formiranja tkiva.Treći aspekt projekta je validacija fizičke strukture i funkcionalnosti nosača in vitro. Model stanica će uključivati stanice kože i oka. Stanice će se pratiti kroz procjene imunoloških, mikrobioloških, biokemijskih i enzimskih aktivnosti, nakon čega slijedi antibakterijski test, te test citotoksičnosti i kancerogenosti.]]></summary_hr><summary_en><![CDATA[The main focus of this interdisciplinary project proposal is the development of custom tailored fibrous scaffold prototype for cells culture based on the textile technique of electrospinning. The big challenge in electrospun scaffolds is the need of a dual structure, i.e. pores with diameters big enough (macro scale) to facilitate cells penetration and fibres small enough (nano scale) to mimic the native extracellular matrix. The unique contribution of this project proposal is based on the combination of both techniques of electrospinning. Solution electrospinning and melt electrospinning to be used for the fabrication of nano fibers and micro fibers alternating layered scaffolds. Additionally cells surface adhesion will be enhanced by a target surface topography prepared based on custom tailored collectors. The second aspect is the design of scaffolds custom functionality including antibacterial property and cellular processes stimulating property based on biological compounds. Project final goal is to select scaffolds with optimal architecture and introduce them with multifunctionality. Scaffolds multifunctionality will be based on systematic study of the optimal condition defining co-existence of both functions, the antibacterial property and controlled release of the biological compounds. Scaffolds materials are polycaprolactone and polyurethane as the matrices combined with silk fibroin to further enhance cells surface adhesion. The scaffolds will be studied systematically in regard to their mechanical integrity as well, to meet the requirements of a construction, stiff enough to withstand neo-tissue formation. Project third aspect is the validation of the scaffolds physical structure and functionality in vitro. Model cells will include both skin and ocular cells culture. Cells will be monitored through immunological, microbiological, biochemicals and enzyme activity evaluations, followed by antibacterial, citotoxicity and carcinogenicity tests.  ]]></summary_en></project><project>
<id>4615</id><title_hr><![CDATA[Govori Makarskoga primorja - dijakronija i sinkronija]]></title_hr><title_en><![CDATA[The Dialects of Makarska Coast: Diachronic and synchronicapproaches]]></title_en><user_id>3092</user_id><user_firstLast_name>Ivana Kurtović Budja</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-8448</code><acronim><![CDATA[GOMAPRIDISI]]></acronim><duration>20.03.2017 - 19.03.2021</duration><status>Prekinut</status><financ_value>52.735,22 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filologija, </scie_field_hr><scie_field_en>Philology, </scie_field_en><institution_hr><![CDATA[Institut za hrvatski jezik]]></institution_hr><institution_en><![CDATA[Institute of Croatian Language]]></institution_en><team_members_id>20359, 13303, 1446, 20358, 4665, </team_members_id><team_members_names><![CDATA[Jurica Budja, Filip Galović, Lucija  Šimičić, Dijana Ćurković, Mario Essert, ]]></team_members_names><keywords_hr><![CDATA[govori Makarskoga primorja, dijakronija, sinkronija, dijalektologija, sociolingvistika, korpus, mrežni okvir]]></keywords_hr><keywords_en><![CDATA[Dialects of Makarska coast, Diachronic and synchronic approaches, dialectology, sociolinguistics, textology, network framework ]]></keywords_en><summary_hr><![CDATA[Makarsko je primorje u povijesti bilo zatvorena zemljopisna i politička jedinica zbog svojega zemljopisnog položaja. Sa sjevera graniči s Poljicima, a s juga s Neretvanskom krajinom. Ono je bilo dijelom zapadnoštokavskoga dijalekta hrvatskoga jezika koji se raspao nakon osmanlijskih osvajanja. S migracijama je došlo do preraspodjele dijalekata koji su postojali prije seobe oko ušća Neretve pa su se nakon odlaska govornika biokovsko-cetinskog dijalekta u Istru i Molise (Italija) našli u kontaktu ikavskošćakavski imotski govori nekadanjega livanjsko-vrbaskog dijalekta i ikavskošćakavski govori nekadanjega makarskoprimorskog dijalekta. Cilj je ovoga četverogodišnjeg projekta sustavno dijalektološki istražiti govore Makarskoga primorja, govore u njihovoj okolici te iseljeničke govore u Moliseu. Specifični je cilj projekta povijesnojezično istraživanje kojim će se na korpusu tekstova iz Makarskoga primorja u rasponu od 17. do 19. stoljeća pratiti specifične makarskoprimorske jezične crte čime će se dokazati kontinuitet jezika od najstarijih pisanih spomenika do danas. Uz to provest će se i sociolingvističko istraživanje stavova mladih o svom govoru. Pretpostavka je da su današnji govori Makarskoga primorja dijelom prežitak staroga zapadnoštokavskoga dijalekta. Istraživanje će intenzivnim terenskim i arhivskim radom i uobičajenim metodama provoditi skupina od šest znanstvenika i jednoga doktoranda uz podršku ispitanika iz svake jezične zajednice. Dobiveni rezultati bit će računalno obrađeni i pretraživi prema jezičnim karakteristikama sa sinkronijskoga i dijakronijskoga gledišta čime će se pokazati kontinutit ili diskontinuitet svake od njih. Inovativnost je ovoga projekta što povezuje sinkronijsko i dijakronijsko istraživanje skupine govora te rezultate, zahvaljujući računalnoj obradi, čini javnosti dostupnima.]]></summary_hr><summary_en><![CDATA[In history, the Makarska coast was a closed geographical and political unit due to its geographic position.  The goal of this four year project is to conduct a systematic dialectological analysis of the dialects of Makarska coast, the dialects in their vicinity, and the emigrant dialects in Molise. The specific goal of the project is to use the methods of historical linguistics to analyze the corpus of texts written in the area of Makarska coast from 17th to 19th century, in order to establish the linguistic features which would prove that there is a continuity of language from the oldest written texts until today. Apart from those two goals, a sociolinguistic research of attitudes towards the dialect will be conducted.The hypothesis is that the contemporary dialects of Makarska coast are, for the most part, a continuation of the former West Štokavian dialect. The research includes intensive field and archive research, and will be conducted by six scientists and a postgraduate student, with support by local informants from each observed community. The results will be computationally processed and searchable by linguistic characteristics from a synchronic and a diachronic point of view, and the continuity or discontinuity of each of them will be observable. The innovativeness of this project is in that it connects the synchronic and diachronic research of a group of local dialects, as well as in the availability of its data and results to the public, due to the computational processing.]]></summary_en></project><project>
<id>4629</id><title_hr><![CDATA[Plazmonički alternativni materijali za konverziju solarne energije]]></title_hr><title_en><![CDATA[Plasmonic alternative materials for solar energy conversion]]></title_en><user_id>812</user_id><user_firstLast_name>Jordi Sancho-Parramon</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>PKP</proposal_type><proposal_call>2016-06</proposal_call><code>PKP-2016-06-4469</code><acronim><![CDATA[PAMSEC]]></acronim><duration>01.06.2017 - 31.05.2019</duration><status>Završio</status><financ_value>142.544,30 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, Kemija, </scie_field_hr><scie_field_en>Physics, Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>20425, 2656, 20041, 20097, 21151, 2916, 25286, </team_members_id><team_members_names><![CDATA[Josep Ferré-Borrull, Boris Okorn, Zoran Ereš, Ivana Fabijanić, Stefano (Antonio) Mezzasalma, Vesna Blažek Bregović, Matej Bubaš, ]]></team_members_names><keywords_hr><![CDATA[plazmonički materijali, konverzija solarne energije, tanki slojevi, metalne nanočestice, obnovljivi izvori energije]]></keywords_hr><keywords_en><![CDATA[plasmonics, solar energy conversion, thin films, metal nanoparticles, renewable energy sources]]></keywords_en><summary_hr><![CDATA[Općeprihvaćen temelj ublažavanja efekata klimatskih promjena jest upotreba obnovljivih i održivih izvora energije, od kojih je osnovna upravo sunčeva energija. Efikasna konverzija solarne energije (KSE) će omogućiti fotovoltaicima, foto-termalnim tehnologijama, kao i tehnologiji skladištenja vodika na bazi svjetla da zamjene fosilna goriva i smanje proizvodnju stakleničkih plinova. Kao obećavajući put ka poboljšanju KSE se nedavno pojavilo područje plazmonike. Prilikom pobude plazmoničkih rezonancija unutar metalnih nano-struktura javlja se jaka interakcija između svjetla i materije koja može omogućiti vrlo efikasno iskorištavanje sunčevog svjetla. Iako je nekolicina eksperimenata pokazala prednosti koje plazmonika pruža za KSE, svi su temeljeni na rijetkim i skupim plazmoničkim materijalima poput zlata i srebra te koriste tehonloški vrlo zahtjevne metode nano-strukturiranja.Unutar ovog projekta planiramo povećati efikasnost KSE iskorištavanjem plazmoničkih svojstava širokodostupnih materijala poput aluminija i bakra, te njihovih legura sa srebrom i zlatom. Čini se da loša svojstva tih materijala za određene plazmoničke primjene poput vođenja valova i senzora mogu biti zaobiđena za primjene KSE-a. Navedeni materijali će biti nano-strukturirani korištenjem metoda tankih slojeva i post-depozicijskih tehnika koje su pogodne za niske cijene i masovnu proizvodnju budućih sustava. Potencijalne prednosti i ograničenja tih materijala će se istražiti korištenjem elektrodinamičkih i ab-initio simulacija, te verificirane izradom i karakterizacijom uzoraka. Metalne nano-strukture će biti optimizirane za specifične KSE sustave. Naročito ćemo se fokusirati na cijepanje vode i generiranje vodene pare kao reprezentativnih primjera KSE na velikim i malim skalama. Uspješno ostvarenje projektnih ciljeva će podići potencijal plazmonike iznad nivoa demonstracije i započeti put njezine uspješne implementacije u stvarnim industrijskim primjenama efikasnog iskorištavanja sunčevog svjetla.]]></summary_hr><summary_en><![CDATA[The use of sunlight as the basis for renewable and sustainable energy has been acknowledged as one of the cornerstones for climate change mitigation. Efficient solar energy conversion (SEC) will empower photovoltaics, photothermal and hydrogen photogeneration technologies as competitive candidates to replace fossil fuels and decrease greenhouse gas production in a close future. Recently, plasmonics has appeared as a promising pathway to enhance SEC. The strong light-matter interaction that takes place during excitation of plasmon resonances in metal nanostructures may lead to very efficient sunlight harvesting. Although several experiments have proven the benefits of plasmonics for SEC, they are based on scarce and expensive plasmonic materials (gold and silver) and often use technologically demanding nanostructuring methods. In the present project we aim to increase SEC efficiency by exploiting the plasmonic properties of widely available materials such as aluminum, copper and their alloys with silver and gold. It has been suggested that limitations of these materials for certain plasmonic applications such as waveguiding and sensing can be by-passed for SEC purposes. The materials will be nanostructured using thin film methods and post-depostion treatments that are suitable for low-cost and mass-production of future devices. The potential benefits and limitations of the materials will be investigated using electrodynamics and first-principle numerical simulations and verified by fabrication and characterization of samples in the laboratory. Optimization of material nanostructures will be carried out for specific SEC systems. In particular, we focus on water splitting and steam generation as representative examples of large and small scale SEC schemes. The successful achievement of the project goals will bring the potential of plasmonics beyond the demonstration level and set it on its path towards its implementation in actual solar light harvesting.]]></summary_en></project><project>
<id>4642</id><title_hr><![CDATA[Evaluacijski sustav za ublažavanje CO2]]></title_hr><title_en><![CDATA[EVALUATION SYSTEM FOR CO2 MITIGATION]]></title_en><user_id>5411</user_id><user_firstLast_name>Domagoj Vulin</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>PKP</proposal_type><proposal_call>2016-06</proposal_call><code>PKP-2016-06-6917</code><acronim><![CDATA[ESCOM]]></acronim><duration>01.04.2017 - 31.03.2019</duration><status>Završio</status><financ_value>85.919,44 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Rudarstvo, nafta i geološko inženjerstvo, Strojarstvo, </scie_field_hr><scie_field_en>Mining, petroleum and geological engineering, Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Rudarsko-geološko-naftni fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mining, Geology and Petroleum Engineering]]></institution_en><team_members_id>12942, 13694, 20462, 992, 5703, 5498, 23956, 24003, </team_members_id><team_members_names><![CDATA[Luka Perković, Marija Macenić, Lucija Jukić, Daria Karasalihović Sedlar, Bruno Saftić, Tomislav Kurevija, Maja Arnaut, Amalia Lekić, ]]></team_members_names><keywords_hr><![CDATA[Energetska efikasnost, CO2 emisije, otpadna toplina, naftna i plinska industrija, podzemno skladištenje energije, podzemno skladištenje CO2]]></keywords_hr><keywords_en><![CDATA[Energy efficiency, CO2 emissions, waste heat, oil and gas industry, underground energy storage, underground CO2 storage]]></keywords_en><summary_hr><![CDATA[Naftna i plinska industrija je energetski visoko-intenzivna te proizvodi velike količine CO2. U Hrvatskoj, pored aktivnosti naftne kompanije, termoelektrana i toplana koji se mogu smatrati tzv. točkastim izvorima CO2, manje kompanije ne primjenjuju novije, efikasnije tehnologije. Takve tehnologije moguće je unaprijediti i pri istraživanju i proizvodnji nafte i plina (upstream). Analiza ostvarivosti primjene novih metoda i tehnologija dala bi temelj za dalja istraživanja i analize mogućnosti smanjenja CO2 u ostalim sektorima. Potrebno je izraditi alat u vidu online aplikacije za početne procjene primjene metoda u smislu računanja energije, emisija i troškova bez mjera i istih parametara nakon primjene neke od dostupnih metoda.Na temelju cjelovite sheme za balansiranje električne i toplinske energije, kao i kretanja emisija CO2 i logistike plina vezano uz upstream aktivnosti, analizirale bi se prvo nepostojeće komponente, s ciljem procjena mjera smanjenja emisija CO2 u atmosferu.Pri tome su prisutna dva suprotstavljena cilja s gledišta sveukupne društvene koristi, a to su:(1) maksimiranje smanjenja emisija CO2 (i ostalih ekvivalentnih emisija) u atmosferu s obzirom na investicije, relativno u odnosu na scenarij „bez mjera“(2) maksimiranje sveukupne neto sadašnje vrijednosti (NPV) kao rezultat investicija u projekte smanjenja CO2Dva suprotstavljena cilja vode do rješavanja problema metodom višekriterijske optimizacije, s ciljem pronalaska optimuma opće društvene koristi. Nakon gore opisane analize, izradit će se generički proračuni svakog analiziranog elementa koji bi se modularno mogli uključivati u novi dizajn pojedinih procesa. Zajedno s izrađenom relacijskom bazom prikupljenih podataka, takvi algoritmi bi radili u obliku online aplikacije te omogućili inicijalne analize primjene pojedinih metoda u drugim sektorima i otvoreni pristup informacijama i analizama.]]></summary_hr><summary_en><![CDATA[Oil and gas industry is highly energy intensive and produces significant amounts of CO2. In Croatia, besides activities of oil company and thermal and power plants which can be considered as point sources of CO2, there are small companies which are not implementing new more efficient technologies. There is a room for an improvement for CO2 mitigation at upstream activities during hydrocarbon exploration and production also. The analysis of feasibility of available methods in upstream activities could help to develop the basis for further research and analysis of possibilities for CO2 emission reduction in other sectors. A tool for initial screening of available methods should be developed in form of online application which could calculate energy, cost and CO2 emission without measures (without more efficient methods applied) and the same three parameters with measures. Based on overall heat and power energy scheme, including the CO2 flow path and natural gas logistics related to upstream activities, non-existing components would be analysed with two opposed main objectives in estimation of the overall social welfare:(1) maximization of the CO2 (and equivalent) emission reduction into the atmosphere as a result of CO2 mitigation projects, relative to scenario without measures(2) maximization of the overall net present value (NPV) as a result of investment into the various CO2 mitigation projectsThe two opposing objectives lead to multiobjective optimization, where the overall optimum of social welfare can be found.After such analysis, generic set of equations will be generated for each analysed element in order to design new process in a modular way. Altogether with created relational database, such algorithms would be implemented to online application which would provide screening of applicability of methods to other sectors and open access to information and analysis.]]></summary_en></project><project>
<id>4647</id><title_hr><![CDATA[Novi materijali za pohranu energije]]></title_hr><title_en><![CDATA[New materials for energy storage]]></title_en><user_id>625</user_id><user_firstLast_name>Ivan Halasz</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>PKP</proposal_type><proposal_call>2016-06</proposal_call><code>PKP-2016-06-4480</code><acronim><![CDATA[NEWMATENG]]></acronim><duration>15.05.2017 - 14.05.2019</duration><status>Završio</status><financ_value>260.415,42 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>329, 13551, 2847, 25420, </team_members_id><team_members_names><![CDATA[Nikola Biliškov, Igor Dejanović, Irena Sović, Igor Milanović, ]]></team_members_names><keywords_hr><![CDATA[grafen, aerografit, mehanokemija, skladištenje energije, amidoborani metala, dihalkogenidi prijelaznih metala]]></keywords_hr><keywords_en><![CDATA[graphene, aerographite, mechanochemistry, energy storage, metal amidoboranes, transition metal dihalcogenides]]></keywords_en><summary_hr><![CDATA[Predloženi projekt se temelji na primjeni okolišno prihvatljivih mehanokemijskih metoda u priređivanju materijala u čvrstom stanju za upotrebu u pohrani energije. Fokus će biti na priređivanju glavnine grafena i aerografita (također poznatog kao grafenska spužva ili porozni ugljik), koji će biti funkcionaliziran dihalkogenidima prijelaznih metala (TMCD) i vodikom bogatim metalnim amidoboranima (MAB) za upotrebu npr. u baterijama, za cijepanje vode reakcijom razvoja vodika ili za pohranu vodika. Uspije li ovaj projekt, moći ćemo proizvoditi te materijale u većim količinama te se nadamo da ćemo time doprinjeti napretku hrvatske akademske zajednice, kao i industrije, u svrhu ostvarenja moguće primjene tih materijala na polju elektronike, pohrane energije, baterija, kondenzatora, u katalizi, pročišćavanju, spremnicima vodika, pohrani vodika itd. Očekivani ishod su nove čiste procedure priređivanja glavnine grafena, TMCD-a i MAB-a u čvrstom stanju. Dodatno, razumijevanje mehanizama tih procesa bit će omogućeno in-situ praćenjem mehanokemijskih reakcija. Na kraju, s obzirom na to da porozni materijali omogućuju nanodimenzionalnost čestica MAB-a, bit će priređen impregnirani aerografit te će biti karakteriziran s obzirom na svojstva relavantna za upotrebu u pohrani vodika. Očekujemo da će kombinirani pristup rezultirati značajno unaprijeđenim performansama priređenih MAB-a s obzirom na pohranu vodika. ]]></summary_hr><summary_en><![CDATA[This project proposes to apply environmentally friendly mechanochemical methods for the preparation of solid-state materials for energy-storage applications. The focus will be on the preparation of bulk graphene and aerographite (also known as grahene sponge or porous carbon) which will be funcionalised by transition metal dihalcogenides (TMDC) and hydrogen-rich metal amidoboranes (MAB) for the use e.g. in bateries, water splitting by hydrogen evolution reaction or for hydrogen storage. With the success of this project, we will be able to produce these materials in larger quantities and we hope to further the Croatian academic community as well as industry which are intended to use them to pursue possible applications in the fields of sorption, electronics, batteries, capacitors, catalysis, purification, hydogen fuel tanks, hydrogen storage etc. The expected outcome are novel clean procedures for solid-state preparation of bulk graphene, TMDCs  and MABs.  Additionally, mechanistic understanding of these processes will be provided by in-situ monitoring of mechanochemical reactions. Finally, since porous materials enable nanodimensionality of MAB particles, impregnated aerographite will be prepared and characterized with respect of the use in hydrogen storage applications. It is very probable that this combined approach would result in a considerably improved hydrogen storage performance of prepared MABs.]]></summary_en></project><project>
<id>4649</id><title_hr><![CDATA[Procjena potencijala jadranskih algi za ko-generacijsku proizvodnju biogoriva 3. generacije]]></title_hr><title_en><![CDATA[Assessment of Adriatic Algae Potential in Co-generation Production of 3rd. Generation Biofuel]]></title_en><user_id>533</user_id><user_firstLast_name>Maria Blažina</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>PKP</proposal_type><proposal_call>2016-06</proposal_call><code>PKP-2016-06-9081</code><acronim><![CDATA[A3-PICO-3G]]></acronim><duration>01.04.2017 - 31.03.2019</duration><status>Završio</status><financ_value>265.445,62 eur</financ_value><scie_area_hr>Biotehničke znanosti, Prirodne znanosti, </scie_area_hr><scie_area_en>Biotechnical sciences, Natural sciences, </scie_area_en><scie_field_hr>Biotehnologija, Biologija, Kemijsko inženjerstvo, </scie_field_hr><scie_field_en>Biotechnology, Biology, Chemical engineering, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>467, 20455, 20041, 20497, 4898, 5839, 20488, 451, 20392, 20473, 5520, 318, 23222, 23207, 2911, </team_members_id><team_members_names><![CDATA[Tamara Đakovac, Marko Mužic, Zoran Ereš, Darko Ferenčević, Tarzan Legović, sonja nikolić, Erik Muller, Jelena Godrijan, Lana Magić, Biserka Lukarić Špalj, Tin Klanjscek, Tina Šilović, Andrea Budiša, Ines Haberle, Enis Hrustić, ]]></team_members_names><keywords_hr><![CDATA[biomasa, biogoriva, lipidi, ugljikohidrati, fotobioreaktor, otpadne vode]]></keywords_hr><keywords_en><![CDATA[biomass, biofuels, microalgae, lipids, carbohydrates, photobioreactors, wastewaters]]></keywords_en><summary_hr><![CDATA[Zbog pozitivnog utjecaja na okoliš, postoji vrlo veliki interes za povezivanje sustava bioprerađivačkog uzgoja algi s postojećim industrijskim postrojenjima, kao što su rafinerije nafte i postrojenja za obradu otpadnih voda. U ovom znanstvenom projektu biti će razvijena pouzdana baza za bioprospecting mikroalgi sjevernog Jadrana na temelju numeričkih modela i empirijskih podataka. Ona će se koristiti za daljnji razvoj 3. generacije biogoriva u INA-rafineriji nafte u Urinju. Istražit će se metodologija za odabir najprikladnijih autohtonih vrsta mikroalgi u sjevernom Jadranu i povezanih heterotrofnih bakterija za proizvodnju biorafinerijske sirovine. Potencijal jadranskih mikroalgi za uzgoj ustvrdit će se odabirom različitih vrsta, na temelju (i) korištenja postojećeg znanja, (ii) predviđanja optimalnih uvjeta potrebnih za njihov rast putem numeričkih modela i (iii) eksperimentalne provjere u fotobioreaktoru pod različitim hranibdenim uvjetima. Modeli će biti razvijeni uzimajući u obzir karakteristike otpadnih voda (N, P hranjive tvari, organski C, temperatura i salinitet) te stehiometriju raznih vrsta. Projekcija mikroalgi će se usredotočiti na sljedeće kriterije: prinos biomase, proizvodnju lipida i ugljikohidrata, izdvajanje stanica i ekstrakciju ulja, C16, C18 i zasićenja masnih kiselina. Iskustva stečena u fazi validacije će predstavljati bazu za bioprospecting Jadrana u procesima bio-rafiniranja, omogućujući tako INA-rafineriji nafte poboljšanje postupka za pročišćavanje otpadnih voda kroz razvoj kogeneracije. Takva kogeneracija će imati pozitivan utjecaj na okoliš smanjenjem zagađenja i povećanjem učinkovitosti, kao i pozitivni gospodarski učinak smanjenjem troškova pročišćavanja voda te osigurati dodatnu zaradu od proizvodnje biomase.]]></summary_hr><summary_en><![CDATA[Because of the positive impact on environment, there is a rising interest in connecting boirefinery algal cultivation systems to existing industrial units, such as oil refineries, and wastewater treatment plants. Herein a scientifically reliable platform will be developed for the northern Adriatic microalgae bioprospecting, based on numerical model and empirical data. It will be used for further development of 3rd generation biofuel in INA-oil refinery in Urinj. The methodology for selection of the most suitable microalgae species indigenous to northern Adriatic and associated heterotrophic bacteria, will be explored for production of biorefinery feedstock. The potential of Adriatic microalgae for cultivation will be acquired through selection of candidate species, based on (i) the survey of existing knowledge, (ii) prediction of the optimum required growth conditions through numerical models and (iii) their experimental verification under various feeding-regimes of the photobioreactor. Models will be developed taking into account wastewater characteristics (N, P nutrients, organic C, temperature, salinity) and stoichiometry of the various species. Screening of microalgae will focus on following criteria: biomass yield, lipid and carbohydrate productivity, cells harvesting and oil extractability, C16, C18, and FA saturation. Lessons learned during validation phase will provide a platform for the Adriatic bioprospecting in biorefining processes, thus enabling INA-oil refinery to improve the wastewater cleanup procedure through co-generation development. Such co-generation would have a positive environmental impact by reducing pollution and increasing efficiency, as well as positive economic effect by reducing costs of water purification and providing added revenue from the biomass production.]]></summary_en></project><project>
<id>4650</id><title_hr><![CDATA[Izravna oporaba komunalne otpadne vode za navodnjavanje membranskim tehnologijama]]></title_hr><title_en><![CDATA[Direct reuse of municipal wastewater for agriculture irrigation with membrane technologies]]></title_en><user_id>20202</user_id><user_firstLast_name>Davor Dolar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>PKP</proposal_type><proposal_call>2016-06</proposal_call><code>PKP-2016-06-8522</code><acronim><![CDATA[ReHOHMem]]></acronim><duration>01.04.2017 - 31.03.2019</duration><status>Završio</status><financ_value>198.143,04 eur</financ_value><scie_area_hr>Tehničke znanosti, Prirodne znanosti, </scie_area_hr><scie_area_en>Technological sciences, Natural sciences, </scie_area_en><scie_field_hr>Kemijsko inženjerstvo, Kemija, Temeljne tehničke znanosti, </scie_field_hr><scie_field_en>Chemical engineering, Chemistry, Basic engineering sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet kemijskog inženjerstva i tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Chemical Engineering and Technology]]></institution_en><team_members_id>20206, 20261, 4216, 20232, 12557, 20234, 2711, 20409, 20229, 20269, 20233, </team_members_id><team_members_names><![CDATA[Krešimir Košutić, Marko Racar, Danijela Ašperger, Sanja Radman, Dario Omanović, Jasmin Pađan, Marinko Markić, ANA ŠPEHAR, Katarina Jambrošić, Nada Glumac, Natalija Kolenić, ]]></team_members_names><keywords_hr><![CDATA[komunalna otpadna voda, poljoprivreda, oporaba, navodnjavanje, ultrafiltracija, nanofiltracija, reverzna osmoza, membranski bioreaktor]]></keywords_hr><keywords_en><![CDATA[municipal wastewater, agriculture, reuse, irrigation, ultrafiltration, nanofiltration, reverse osmosis, membrane bioreactor]]></keywords_en><summary_hr><![CDATA[Industrijalizacija, porast ljudske populacije i klimatske promjene tri su ključna uzroka vezana uz globalni problem opskrbe vodom namijenjene za piće, te za industrijske i poljoprivredne potrebe. Hrvatska je relativno bogata vodom s procijenjenim kapacitetom pitke vode od oko 9.1 Mm3, no posljednjih godina klimatske promjene sve više dolaze do izražaja kroz dugotrajna sušna razdoblja. Ovaj problem posebno se odnosi na poljoprivredni sektor, pri čemu su prinosi poljoprivrednih kultura i sigurnost opskrbe hranom postali nestabilni i ugroženi. Klimatska predviđanja poručuju da budućnost nije puno svjetlija pa je nužno uvoditi napredne i održive tehnologije kojima će se u industrijskom mjerilu iskorištavati raspoloživi vodeni kapaciteti za prevladavanje uzroka krize.Membranske tehnologije spadaju u napredne i održive tehnologije obrade voda koje se snažno razvijaju i sve intenzivnije primjenjuju, ekonomski su opravdane, nisu destruktivne, učinkovito zadovoljavaju strogo propisane standarde, te su ekološki održive. Namjera je ispitati primjenu membranskih ekološki održivih tehnologija (MEOT) mikrofiltracije, ultrafiltracije, nanofiltracije i reverzne osmoze, te membranskog bioreaktora za oporabu (adekvatna obrada s ciljem ponovnog korištenja) komunalnih otpadnih voda i njihovu upotrebu u poljoprivredi.Tijekom projekta pratit će se značajan broj parametara uključujući patogene mikroorganizme, kemijska zagađivala (biorazgradljive organske tvari, makronutrijenti, mikronutrijenti, teški metali, anorganske soli, hormoni, itd.) i odabrane kategorije novih zagađivala određena Provedbenom odlukom komisije (EU) 2015/495.Cilj ovog projekta je pokazati mogućnost oporabe otpadnih voda komunalnog porijekla za potrebe navodnjavanja primjenom MEOT-a, povećati poljoprivrednu proizvodnju, kroz povećanu dostupnost vode integriranim i održivim korištenjem vodnih resursa. Oporabom otpadnih voda postiže se efekt smanjenja intenzivnog crpljenja površinskih i podzemnih voda namijenjenih piću.]]></summary_hr><summary_en><![CDATA[Industrialization, human population increase and climate change are three crucial factors related to global problems associated with drinking water supply for industrial and agricultural purposes. Croatia is rich with water with estimated capacity around 9.1 Mm3, but over the last year’s climate changes are increasingly becoming pronounced through the long dry periods. This problem is particularly related to the agricultural sector and thus the yields of agricultural crops and food security have become unstable and vulnerable. Climate prediction points out that the future is not much brighter so it is necessary to implement advanced and sustainable technologies which will be able to use available water source to overcome the causes of the crisis.Membrane technologies belong to advanced and sustainable technologies of water treatment that are strongly developing, applying more intensively, economically are justified, are not destructive, effectively meet the strict prescribed standards and are environmentally sustainable. The intention is to investigate application of membrane ecologically sustainable technologies (MEST) microfiltration, ultrafiltration, nanofiltration, reverse osmosis, and membrane bioreactor for reuse of municipal wastewater for agriculture.During the project significant number of parameters will be monitored including pathogen microorganisms (bacterias, viruses), chemical contaminants (biodegradable organics, macronutrients, micronutrients, metals, inorganic salts, hormones, etc.) and selected emerging contaminants determined by Commission implementing decision (EU) 2015/495.The goal of this project is to show possibility of municipal wastewater reuse for agricultural irrigation using advance membrane technologies, increase agricultural production, through increased water availability with integrated and sustainable use of water sources. Reuse of wastewater helps to decrease over-abstraction of surface and groundwater used for drinking.]]></summary_en></project><project>
<id>4655</id><title_hr><![CDATA[Vinogradarstvo i klimatske promjene na području Hrvatske/]]></title_hr><title_en><![CDATA[VITiculture and CLImate Change in Croatia]]></title_en><user_id>11142</user_id><user_firstLast_name>Maja  Telišman Prtenjak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>PKP</proposal_type><proposal_call>2016-06</proposal_call><code>PKP-2016-06-2975</code><acronim><![CDATA[VITCLIC]]></acronim><duration>03.04.2017 - 02.04.2019</duration><status>Završio</status><financ_value>224.308,18 eur</financ_value><scie_area_hr>Prirodne znanosti, Biotehničke znanosti, Društvene znanosti, </scie_area_hr><scie_area_en>Natural sciences, Biotechnical sciences, Social sciences, </scie_area_en><scie_field_hr>Geofizika, Poljoprivreda, Ekonomija, </scie_field_hr><scie_field_en>Geophysics, Agriculture, Economy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>7643, 17750, 20393, 12576, 13543, 20276, 13508, 20366, 4418, 20281, 20318, 20130, 19366, 246, </team_members_id><team_members_names><![CDATA[Branko Grisogono, Andreina Belušić, Antun Marki, Marko Karoglan, Jasminka Karoglan Kontić, Mirela Osrečak Osrečak, Željko  Andabaka, Ivana Tomaz, Silvio  Šimon, Ivana Vladimira Petric, Renata Leder, IVAN PRŠA, Željka Kordej-De Villa, Maja Vehovec, ]]></team_members_names><keywords_hr><![CDATA[klimatske promjene, agroklimatski indeksi, tuča, fenologija vinove loze, defolijacija, fenolni sastav, analiza isplativosti meteoroloških usluga]]></keywords_hr><keywords_en><![CDATA[climate change, agroclimate indices, hail, grapevine phenology, leaf removal, phenolic composition, cost-benefit analysis of meteorological service]]></keywords_en><summary_hr><![CDATA[U Hrvatskoj se uočava trend porasta srednje godišnjetemperature zraka kao i velika varijabilnost u mjerenojekstremnoj oborini. Klimatološka istraživanja koja se provoderegionalnim klimatskim modelima pokazuju da će se ekstremnevrijednosti temperature i oborine iznad Europe intenzivirati ubudućoj klimi. Spomenute promjene temperature i oborine (aonda često i duboke konvekcije) imaju velik utjecaj navinogradarstvo, s obzirom da od svih živih organizama biljkeprve reagiraju na promjenu prizemne temperature. Promjenatemperature uslijed klimatskih promjena utjecat će: (i) različitona razvojne faze vinove loze u pojedinim vinorodnim područjimadiljem Hrvatske (tj. njihove fenološke karakteristike) te (ii)različito na različite sorte. Istovremeno povećanje temperaturemijenja raspodjelu konvektivne aktivnosti (oluje) time i pojavutuče koje su procijenjene kao drugi najveći uzrok materijalnihšteta u Hrvatskoj. Ujedno je uočen i trend povećanjaprosječnog trajanja padanja tuče na temelju postojećihmjerenja dobivenih u kopnenom dijelu Hrvatske. Zbognavedenog projekt ima nekoliko ciljeva. Na temelju dosadašnjihmeteoroloških podataka i arhivske građe analizirat će sesadašnje stanje te uspostaviti sustav praćenja ključnihfenoloških faza vinove loze uslijed klimatskih promjena. Namjeraje povezati dozrijevanje i kakvoću grožđa s agroklimatskimindeksima te odrediti povezanost parametara tuče sa stupnjemoštećenja vinove loze. Svrha je također omogućiti podrobnijuagronomsku i gospodarsku evaluaciju hrvatskih autohtonihsorata vinove loze u sadašnjoj i budućoj klimi. Ujedno će seodrediti (pomoću agroklimatskih indeksa) promjene u budućojklimi odnosno dat će se procjena povećanja ili smanjenjaodređenog tipa vremena u budućoj klimi koji pogoduju razvojutuče u Hrvatskoj. Pri tome će se ispitivati uspješnost pojedinihampelotehničkih mjera kako bi se bolje procijenila učinkovitostzahvata u cilju adaptacije vinogradarske tehnologije naklimatske promjene.]]></summary_hr><summary_en><![CDATA[in Croatia is observed the increasing trend in mean annual airtemperature and the large variability in the measured extremeprecipitation from prominent drought to severe flooding.Climatological studies based on regional climate models showthe intensification of the extreme values of temperature andprecipitation over Europe in the future climate. These changes intemperature and precipitation have a great impact onviticulture, considering that of all living organisms, plants reactfirst to the change of surface temperature. Due to climatechange, changes in temperature will affect: (i) differently alldevelopmental stages of vines in certain wine-growing areas inCroatia (i.e. their phenological characteristics) and (ii) differentlyon different varieties. At the same time, the temperatureincrease changes convective activity (storms) and thus theoccurrence of hail that are estimated as the second biggestcause of material damage in Croatia. The trend of increasingaverage duration of hailfall was also observed on the basis ofmeasurements obtained in the low land of Croatia. Due tomentioned, this project has several goals. Based onmeteorological and climatological datasets and wine andgrapevine archive data, the current situation and a monitoringsystem of key phenological phases of the vine due to climatechange will be analyzed and established. Furthermore, the aimis to link the ripening and quality of grapes with agroclimaticindices and determine the relationship between hail parametersand the degree of damages in grapevines. The purpose is alsoto enable: (i) detailed agronomic and economic evaluation forpreserving Croatian autochthonous grapevine varieties, (ii)determination of climate changes through agroclimatic indices indifferent future periods and (iii) an estimation of the increase ordecrease in certain weather types which favor convectivedevelopments (and hail).]]></summary_en></project><project>
<id>4658</id><title_hr><![CDATA[Procjena adaptabilnosti hrvatskog sortimenta kukuruza i soje u funkciji oplemenjivanja za tolerantnost na sušu]]></title_hr><title_en><![CDATA[Adaptability assessment of maize and soybean cultivars of Croatia in the function of breeding for drought tolerance]]></title_en><user_id>2923</user_id><user_firstLast_name>Ivan Pejić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>PKP</proposal_type><proposal_call>2016-06</proposal_call><code>PKP-2016-06-8290</code><acronim><![CDATA[AGRO-DROUGHT-ADAPT]]></acronim><duration>01.04.2017 - 31.03.2019</duration><status>Završio</status><financ_value>261.065,76 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Agronomski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Agriculture]]></institution_en><team_members_id>7754, 2976, 20437, 19290, 6287, 20433, 3305, 20429, 20417, 20416, 20418, 20451, 3893, 12605, 20440, 20444, 20431, 20445, 18945, 20410, 5091, 20419, 4812, 20408, 20499, 20481, 22835, 22833, 22834, 23526, 5364, 21410, </team_members_id><team_members_names><![CDATA[Hrvoje Šarčević, Maja Žulj Mihaljević, Snježana Kereša, Ana Lovrić, Jerko Gunjača, Marija Pecina, Domagoj Šimić, ALEKSANDRA SUDARIĆ, Ivica Buhiniček, Mirko Jukić, Domagoj  Stepinac, Krešo Pandžić, Nataša Strelec Mahović, Milan Mesić, Mirta Rastija, Dario Iljkić, Bojan Marković, Ivan Varnica, Sara Godena, Elvino Šetić, Gvozden Dumičić, Vesna Samobor, Antun Jambrović, Stipe Ivić, Davor Tomsic Tomsic, Tanja Likso, Snježana Čavlovićak, Marko Čajić, Saša Vuletić, Krešimir Đuretec, Renata Erhatić, Goran Jukić, ]]></team_members_names><keywords_hr><![CDATA[Suša, adaptabilnost, oplemenjivanje, selekcija, kukuruz, soja]]></keywords_hr><keywords_en><![CDATA[Drought, adaptability, breeding, selection, maize, soybean ]]></keywords_en><summary_hr><![CDATA[Od svih ekstremnih vremenskih nepogoda izazvanih klimatskim promjenama suša ima najveći ekonomski utjecaj na društvo (1). Suša je glavni i najčešći uzrok nerentabilnih prinosa najvažnijih poljoprivrednih kultura u RH (2). Prema globalnim i lokalnim scenarijima klimatskih promjena, u bližoj budućnosti se očekuju sve češće suše jačeg intenziteta (3), a što će utjecati na održivost proizvodnje najvažnijih poljoprivrednih kultura od strateške važnosti za RH.U dvije uzastopne godine ispitat će se genetska adaptabilnost najvažnijih i novih sorata kukuruza i soje u pogledu tolerantnosti na sušu radi identifikacije superiorne germplazme i metoda selekcije za potrebe oplemenjivanja. Konzorcij od 29 istraživača iz 9 partnerskih ustanova provest će poljske pokuse na 19 lokacija širom Hrvatske (kontinentalno i priobalno područje) s namjerom zahvaćanja „slučajne suše“ i procjene niza istih genotipova u različitim klimatskim scenarijima i njihove reakcije na optimalne i sušne uvjete. U svim pokusima će se analizirati faze rasta, razvoja i najvažnija agronomska svojstva pojedinih genotipova. Usporedno će biti provedena i laboratorijska fiziološka i molekularno-genetička ispitivanja radi „brze detekcije tolerantnih genotipova“, a ove metode će biti validirane sa stvarnim rezultatima iz poljskih pokusa. Na svim pokusnim lokacijama će biti prikupljani i analizirani mikrometeorološki podaci potrebni za procjenu pojave, intenziteta i trajanja suše.Naprednom statističkom analizom meteoroloških i bioloških podataka identificirat će se genotipovi kukuruza i soje koji najbolje podnose uvjete suše te metodika ispitivanja koja najbolje diskriminira takve genotipove, a što bi unaprijedilo proizvodnju i proces selekcije na ovo svojstvo u tekućim oplemenjivačkim programima (4). Detaljna analiza pokusnih i povijesnih klimatskih podataka iz redovnih meteoroloških mjerenja omogućit će preciznu procjenu stvarne ekonomske štete u poljoprivredi u Hrvatskoj, kao osnove za buduće razvojne politike.]]></summary_hr><summary_en><![CDATA[Among all extreme weather conditions caused by climate change, drought has the greatest economic impact on society (1). It is the main and the most common cause of unprofitable yields of most important agricultural crops in the Republic of Croatia (RH) (2). According to global and local climate change scenarios, more frequent and severe drought is expected in the near future (3), which will affect the sustainability of the most strategically important crops for RH.The genetic adaptability of the most important new varieties of maize and soybean will be examined in two consecutive years in terms of their drought tolerance to identify superior germplasm and selection methods for breeding purposes. A consortium of 29 researchers from 9 partner institutions will carry out field trials at 19 locations around Croatia (continental and coastal areas) to grasp &#39;&#39;random drought&#39;&#39; and evaluate selected genotypes in different climatic scenarios in order to assess their reactions to optimum and drought conditions, through different growth stages as reflected to the most important agronomic traits. Simultaneously, laboratory physiological and molecular genetic testing will be conducted for &#39;&#39;fast detection of tolerant genotypes&#39;&#39;, and validated with actual results from field trials. At all field locations micrometeorological data will be collected and analysed in order to estimate the appearance, intensity and duration of the drought.Advanced statistical analysis of meteorological and biological data will enable the identification of the best drought tolerant maize and soybean genotypes and the best discriminating testing methodology, which would improve the production and selection for this trait in the current breeding programs (4). A comprehensive analysis of the experimental and historical climate data from regular meteorological measurements will enable an accurate assessment of actual economic losses to agriculture in Croatia, as a basis for future developmental policies.]]></summary_en></project><project>
<id>4660</id><title_hr><![CDATA[Smanjenje emisija stakleničkih plinova upotrebom gradskog i poljoprivrednog otpada u proizvodnji bilja]]></title_hr><title_en><![CDATA[Reduction of greenhouse gas emissions through urban and agricultural waste utilization in plant production]]></title_en><user_id>6613</user_id><user_firstLast_name>Dean Ban</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>PKP</proposal_type><proposal_call>2016-06</proposal_call><code>PKP-2016-06-9041</code><acronim><![CDATA[REDGREENPLANT]]></acronim><duration>01.04.2017 - 31.03.2019</duration><status>Završio</status><financ_value>265.018,38 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Institut za poljoprivredu i turizam]]></institution_hr><institution_en><![CDATA[Institute of Agriculture and Tourism in Poreč]]></institution_en><team_members_id>12403, 20413, 20387, 19017, 20472, 3037, 6861, 6108, 20438, 20523, 20521, 6490, 20475, 22828, 22830, 25256, 19688, </team_members_id><team_members_names><![CDATA[Igor Pasković, Marko Černe, Marija Romić, Aleksandra Perčin, Marina Diana Igrc, Igor Palčić, Milan Oplanić, Barbara Soldo, Vilim  Filipović, Josip Gugić, Ljudmila Benedik, Josipa Perković, Tea Zubin Ferri, Nikola Major Major, Danko Cvitan, Radojko Jaćimović, Zoran Užila, ]]></team_members_names><keywords_hr><![CDATA[kompost, biočar, piroliza, poljoprivreda, gnojivo]]></keywords_hr><keywords_en><![CDATA[compost, biochar, pyrolise, agriculture, fertilizer]]></keywords_en><summary_hr><![CDATA[Emisije stakleničkih plinova (SP) i klimatske promjene u jakoj su uzročno posljedičnoj vezi s poljoprivredom. Razlog tome je, što se iz poljoprivredne proizvodnje oslobađa značajna količina SP, a promjena klime utječe direktno na promjenu pogodnosti prostora za uzgoj poljoprivrednih vrsta bilja i životinja. Intenzivna se poljoprivreda, između ostalog, zasniva na velikoj potrošnji gnojiva, a njihova proizvodnja zahtjeva mnogo energije i stvara značajne emisije SP. Jedan od globalno prihvaćenih pristupa smanjenju emisija SP je smanjena upotreba mineralnih gnojiva, zamjenom za neki drugi oblik gnojiva. Gradski i poljoprivredni otpad koji neobrađen predstavlja ozbiljnu prijetnju zaštiti okoliša, obradom može postati kvalitetno gnojivo koje može zamijeniti mineralno. Naime, upotreba kompostiranog komunalnog mulja i maslinove komine, kao i upotreba biočara iz tih materijala, postaje sve zanimljivija zbog njihovog eventualnog pozitivnog utjecaja u obliku dodataka tlu, na strukturu i plodnosti tla, vraćanje hraniva u tlo te prinos. U mediteranskom području česti su tipovi tla s nedostatkom fosfora, te je gnojidba fosfornim gnojivima bitna za optimiziranje rasta usjeva. Istovremeno, organski otpad je često bogat fosforom, posebice komunalni mulj. Promatrajući utjecaj poljoprivrede na emisije SP i ograničenja koja postoje pri primjeni mineralnih gnojiva, ciljevi ovog projekta su istražiti upotrebu komunalnog mulja i komine u obliku komposta i biočara kao dodataka tlu sa svrhom povećanja plodnosti i smanjenja emisija SP u odnosu na primjenu mineralnih gnojiva. U ovom projektu istražit će se utjecaj navedenih dodataka tlu na fizikalna i kemijska svojstva te mikrobiološku aktivnost tla na primjeru crvenice i rendzine, rast i fiziologiju biljaka, usvajanje hraniva i toksičnih metala, te na kvalitetu i prinos istraživanih biljaka. Ciljevi predloženog projekta usmjereni na analizu postojećih i razvoj novih načina smanjenja emisija SP u poljoprivredi odgovaraju uvjetima natječaja.]]></summary_hr><summary_en><![CDATA[Greenhouse gas (GHG) emissions and climate changes are in strong causal relationship with agriculture. Agricultural production releases a significant amount of GHG, and at the same time climate changes affects directly the suitability of environment for plant and animal growing. Intensive agriculture is based on a large consumption of fertilizers and their production requires an ample energy and generates significant GHG emissions. One of the widely recognized approaches to reduce the GHG emissions is the reduced use of mineral fertilisers by their replacement with other forms of fertilizers. Untreated urban and agricultural waste represents a serious threat to environment; however after treatments could become a fertilizer that can replace the mineral one. The use of composted sewage sludge and olive pomace, and biochar derived from these wastes, as soil amendment, has been given an attention due to their positive effect on the soil structure, fertility, nutrient recycling, and yield. In Mediterranean area, P-low soils are widely present, and P fertilization is important strategy to optimize crop growth. At the same time, organic waste are often rich on P, particularly sludge waste. Considering the agricultural contribution to GHG emission and limitations in mineral fertilizers supply, the objectives of the project will focus on efficiency of sewage sludge and olive pomace as compost and biochar as soil amendments on increasing soil fertility and reducing GHG emissions compared to mineral fertilizers. The effect of waste amendments on physical and chemical properties and microbiological activity of terra rossa and rendzina soils, plant growth and physiological response, nutrients and toxic metals utilization, yield and quality of tested plant will be explored. The objectives of the proposed project are focused on analysis of existing application and development of new measures for reduction of GHG emissions in agriculture and they fulfil the goal of the call.]]></summary_en></project><project>
<id>4663</id><title_hr><![CDATA[Održivi koncept integracije distribuiranih spremnika energije]]></title_hr><title_en><![CDATA[Sustainable concept for integration of distributed energy storage systems]]></title_en><user_id>7001</user_id><user_firstLast_name>Tomislav Capuder</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>PKP</proposal_type><proposal_call>2016-06</proposal_call><code>PKP-2016-06-3190</code><acronim><![CDATA[SUCCESS]]></acronim><duration>01.04.2017 - 31.03.2019</duration><status>Završio</status><financ_value>126.790,10 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, Računarstvo, Strojarstvo, </scie_field_hr><scie_field_en>Electrical engineering, Computer sciences, Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>20487, 20181, 904, 13621, 20291, 17618, 20482, 20524, 20476, 23193, 23194, </team_members_id><team_members_names><![CDATA[Ante Marušić, Vedran Bobanac, Tomislav Dragičević, Ivan Pavić, Hrvoje Bašić, Ivan Periša, Marko Brkljačić Brkljačić, Danijel Habijan, Slavko Krajcar, Mirna Gržanić, Tomislav Pavlović, ]]></team_members_names><keywords_hr><![CDATA[Fleksibilni distribucijski sustavi, Laboratorijska ispitivanja, Niskougljični energetski sustavi, Napredne energetske mreže, Spremnici energije]]></keywords_hr><keywords_en><![CDATA[Battery storage, Distribution system operation and planning, Energy markets, Flexible distribution systems, Laboratory testing, Low carbon systems]]></keywords_en><summary_hr><![CDATA[Gotovo sve energetske strategije potiču integraciju niskougljičnih tehnologija, bilo na strani proizvodnje bilo na strani kranjih potrošača, s ciljem smanjenja utjecaja energetskog sektora na klimatske promjene. Ove nove tehnologije donose i nove izazove, posebice u planiranju i vođenju energetskog sustava, s obzirom da ih karakterizira veća varijabilnost i nesigurnost u odnosu na „tradicionalni“ energetski sustav. Ukoliko želimo postići ciljeve smanjenja stakleničkih plinova, utjecaj ovih varijabilnosti i nesigurnost potrebno je minimizirati te maksimalno iskoristiti proizvodenu energiju iz obnovljivih izvora energije. Spremnike energije smatra se ključnim tehnologijama u razvoju budućih niskougljičnih energetskih sustava. Sposobnost spremnika da pruže usluge fleksibilnosti i smanje nesigurnost koji obnovljivi izvori energije unose u pogon elektroenergetskog sustava, čini ih izuzetno atraktivnom tehnologijom u tranziciji prema održivom energetskom sustavu. Instaliranjem spremnika blizu mjesta potrošnje koncept distribucijskih mreža, koje su tradicionalno pasivne mreže, znatno se mijenja. Uz to, uloga spremnika u budućem elektroenergetskom sustavu trebala bi biti višestruka; od povečanih mogućnosti upravljanja mrežom, smanjenja troškova pogona, povećanja sigurnosti opskrbe krajnjih kupaca pa do stabiliziranja cijena električne energije.U prvom dijelu projekta biti će provedena detaljna analiza regulatornih i tržišnih okvira u Europi i SAD-u s ciljem detektiranja najboljih praksi u razvoju distribucijskih sustava i tržišta.Drugi dio projekta biti će usmjeren na razvoj novih algoritama za vođenje i pogon distribucijskih sustava, pri čemu će tehnologije spremnika energije imati ključnu ulogu u pružanju usluga fleksibilnosti i operatoru sustava, ali krajnjem korisniku.U završnom, trećem, dijelu biti će razvijeno laboratorijsko okruženje za ispitivanje mogućnosti baterijskih sustava da pruže tražene usluge fleksibilnosti, definirane u drugom dijelu projekta.]]></summary_hr><summary_en><![CDATA[A number of energy strategies today encourage the integration of low carbon technologies at both the generation side and the consumer side with the goal of reducing the impact of the energy sector on climate change. These new technologies are creating challenges in operation and development of the power system due to their more uncertain and variable behaviour compared to “traditional” power systems. To achieve the goals of reducing the greenhouse gas emissions these uncertainties and variabilities need to be minimized, utilizing the production from renewable sources as much as possible.Energy storage is seen as one of key technologies in enabling the development of the low-carbon electricity system. By providing flexibility and alleviating the intermittent nature of renewable, energy storage has the potential to bridge the gap towards highly sustainable renewable energy systems. These units are expected to be placed closer to the place of consumption. This means that the distribution grid, which has traditionally been a passive network, will go through significant changes.The role of storage in future all electric systems should be multiple; from improving the management of distribution networks, reducing costs, improving the security and efficiency of electricity distribution network to stabilising market prices for electricity.In the first part of the project we will conduct a detailed analysis of the regulatory and market framework in EU and USA with the goal of detecting best practices in development of distribution systems and markets.Second part of the projects will focus on developing novel algorithms for planning and operating the distribution system, where technologies such as battery storage play a crucial role in providing flexibility services to both the final users and network operator.In the third and last part of the project we will focus on testing the capabilities of batteries to provide multiple services defined in the second part.]]></summary_en></project><project>
<id>4744</id><title_hr><![CDATA[Učinkovito bežično napajanje]]></title_hr><title_en><![CDATA[Efficient wireless power supply]]></title_en><user_id>5120</user_id><user_firstLast_name>Davor Vinko</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-5373</code><acronim><![CDATA[EWPS]]></acronim><duration>01.03.2018 - 28.02.2023</duration><status>Završio</status><financ_value>230.935,42 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera Osijek, Fakultet elektrotehnike, računarstva i informacijskih tehnologija Osijek]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Electrical Engineering, Computer Science and Information Technology Osijek]]></institution_en><team_members_id>22470, 24016, 24905, 29701, </team_members_id><team_members_names><![CDATA[Vanja  Mandrić Radivojević , Krešimir Grgić, Domagoj Bilandžija, Luka Filipović, ]]></team_members_names><keywords_hr><![CDATA[bežični prijenos energije, napajanje, učinkovitost, blisko polje, internet stvari]]></keywords_hr><keywords_en><![CDATA[wireless power transmission, power supply, efficiency, near field, internet of things]]></keywords_en><summary_hr><![CDATA[Mogućnost bežične komunikacije je standarna funkcionalnost modernih elektroničkih uređaja.  Od uređaja se očekuje mogućnost međusobnog povezivanja i razmjene podataka te istovremeno podržavanje različitih komunikacijskih tehnologija (WiFi, 3G, BlueTooth, GSM, ...). Sljedeći korak u daljnjem razvoju elektroničkih uređaja jest proširivanje bežične funkcionalnosti na napajanje uređaja. Moderni elektronički uređaji nude visoku razinu bežične povezivnosti, ali je napajanje uređaja (baterijsko ili spajanje na pojnu mrežu) ono što stoji na putu do potpune autonomije uređaja.    Projektni prijedlog obuhvaća istraživanje rezonantnog magnetskog bežičnog prijenosa energije, kroz koje bi se razvila tehnologija za učinkovito bežično napajanje elektroničkih uređaja. Unutar projekta elektronički su uređaji podijeljeni u dvije kategorije koje se bitno razlikuju prema potrošnji i potrebnom stupnju slobode položaja i autonomije. U prvoj kategoriji su uređaji vrlo niske potrošnje koji su dio IoT svijeta (npr. bežični senzorski čvorovi) i koji zahtijevaju visok stupanj slobode položaja. Druga kategorija su uređaji potrošnje od 1 W do 100 W (npr. gadgeti, prijenosna računala) kod kojih je potrebna značajno veća snaga. Cilj projektnog prijedloga je ostvariti učinkovito bežično napajanje u višekorisničkom okruženju, gdje jedan izvor (predajnik) bežično napaja više trošila (prijemnika).     Istraživanje unutar projekta će rezultirati definiranim okvirom za učinkovito bežično napajanje elektroničkih uređaja, prilagođeno vrsti i namjeni uređaja, s posebnim naglaskom na kompromis između potrošnje i autonomije.  ]]></summary_hr><summary_en><![CDATA[Wireless communication is standard functionality of modern electronic devices. It is expected that devices can interact and exchange data wirelessly by employing various communication technologies (WiFi, 3G, BlueTooth, GSM, ...). The next step in further development of electronic devices is to expand wireless functionality to the power supply of the device. Modern electronic devices offer a high level of wireless connectivity, but the power supply of the device (battery or power grid) stands on the way to fully autonomous devices.     The project proposal focuses on resonant magnetic wireless power transmission. Research aims to develop technology for efficient wireless power supply for electronic devices. Within the project, electronic devices are divided into two categories that differ significantly with respect to power consumption and required degree of freedom of position and autonomy. In the first category are electronic device with very low power consumption that are a part of IoT world (e.g. Wireless sensor nodes). They require a high degree of freedom of movement. In the second category are electronic devices whose power consumption is in the range from 1 W to 100 W (e.g. gadgets, laptops). They have significantly higher power demand. The objective of the project proposal is to develop efficient wireless power supply in a multi-user environment, where one power source (transmitter) can wirelessly supply more devices (receivers).       The research within the project will result in a defined framework for the efficient wireless power supply, adapted to the type and the purpose of the device, with emphasis on a compromise between device consumption and autonomy.]]></summary_en></project><project>
<id>4748</id><title_hr><![CDATA[Formalno rasuđivanje i semantike]]></title_hr><title_en><![CDATA[Formal reasoning and semantics]]></title_en><user_id>21409</user_id><user_firstLast_name>Tin Perkov</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-9219</code><acronim><![CDATA[FORMALS]]></acronim><duration>01.12.2017 - 30.11.2022</duration><status>Završio</status><financ_value>148.981,35 eur</financ_value><scie_area_hr>Prirodne znanosti, Tehničke znanosti, Društvene znanosti, </scie_area_hr><scie_area_en>Natural sciences, Technological sciences, Social sciences, </scie_area_en><scie_field_hr>Matematika, Računarstvo, Informacijske znanosti, Kognitivna znanost, </scie_field_hr><scie_field_en>Mathematics, Computer sciences, Information sciences, Cognitive science, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Učiteljski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Teacher Education]]></institution_en><team_members_id>12963, 21430, 22496, 12516, 4388, 24024, 23890, 25905, 858383, 7040, 865424, 865425, </team_members_id><team_members_names><![CDATA[Tajana Ban Kirigin, Luka Mikec, Aleksandar Hatzivelkos, Marcel Maretić, Benedikt Perak, Branimir Stojanović, Sebastijan Horvat, Mandi Orlić Bachler, Tin Adlešić, Nikolina Filipović, Teo Šestak, Stipe Marić Marić, ]]></team_members_names><keywords_hr><![CDATA[matematička logika, modalna logika, teorija modela, logika u računarstvu, formalno rasuđivanje]]></keywords_hr><keywords_en><![CDATA[mathematical logic, modal logic, model theory, logic in computer science, formal reasoning]]></keywords_en><summary_hr><![CDATA[Projekt će uspostaviti novu istraživačku grupu u području matematičke logike, s ciljem uspostave suradnje među istraživačima čiji dosadašnji rezultati su pretežno teorijski s istraživačima koji su se u dosadašnjem znanstvenom radu fokusirali na primjene. Stoga je naglasak projekta na međusobnoj komunikaciji i diseminaciji, kao i usavršavanju doktoranada koji će se od samog početka znanstvene karijere poticati da razviju ovaj interdisciplinarni pogled. Sadržajno, cilj projekta je međusobno obogaćivanje teorijske i primijenjene logike s naglaskom na primjene logike u računarstvu, ali i obratno, primjene računalnih alata u logičkom i matematičkom istraživanju. Drugi cilj je primjena logike u konkretnim problemima lingvistike ili, općenitije, kognitivnih i informacijskih znanosti, pa i interdisciplinarnih područja u kojima se preklapaju ekonomija i matematika (teorija igara, teorija društvenog izbora). Na prvi pogled vrlo formalna i teorijska disciplina, logika je izrazito primjenjiva, a iznenađuje primjena istih ili sličnih logičkih sistema, osobito modalne logike, u vrlo različitim područjima. Formalizacija donosi pojmovnu preciznost i jasnoću, što omogućuje sigurnost u dokazivanju novih spoznaja, ali i rasvjetljuje kompleksnost problema i otkriva nova pitanja koja u neformalnom rasuđivanju mogu ostati skrivena. Teorijski aspekti projekta obuhvaćaju: 1) istraživanje izražajne snage formalnih jezika metodama teorije modela, 2) adekvatnost i potpunost, odlučivost i složenost logičkih sistema, osobito modalne logike, 3) istraživanje mogućnosti razvoja apstraktne teorije formalnih semantika. Aspekti primjene su: 1) razvoj, istraživanje i formalizacija matematičkih modela za probleme drugih disciplina, 2) razvoj i implementacija algoritama, 3) otkrivanje veza među pitanjima iz prividno različitih područja preko srodnih formalizacija. Projekt predviđa interdisciplinarnu i međunarodnu suradnju.]]></summary_hr><summary_en><![CDATA[A new research group in mathematical logic will be established, with the aim of collaboration between researchers whose previous results were mainly in pure logic and those who previously focused on applications. The emphasis of the project is on mutual communication and dissemination, and training of doctoral students who will be encouraged to develop this interdisciplinary approach from the very beginning of their career. The goal of the project is mutual enrichment of pure and applied logic, with emphasis on applications of logic in computer science, and vice versa, the application of computational tools in logical and mathematical research. Another goal is to apply logic to specific problems of linguistics or, more generally, cognitive and information sciences, as well as interdisciplinary areas in which economics and mathematics overlap (game theory, social choice theory). Even though logic is at the first glance a formal and theoretical discipline, logic is also exceptionally applicable, and it is surprising to see applications of the same or similar formal systems, especially modal logics, in a variety of areas. Formalization brings conceptual precision, clarity and confidence. Formalization also provides new insights of the complexity of problems and allows for discovery of new issues that remain hidden in informal reasoning. The theoretical aspects of the project include: 1) exploring the expressive power of formal languages by methods of model theory, 2) soundness and completeness, decidability and complexity of formal systems, especially modal logics, 3) exploring the possibilities of developing an abstract theory of formal semantics. Application aspects are: 1) development, research and formalization of mathematical models for problems of other disciplines, 2) development and implementation of algorithms, 3) detection of links between seemingly unrelated domains through related formalizations. Interdisciplinary and international collaboration is planned.]]></summary_en></project><project>
<id>4755</id><title_hr><![CDATA[Korisniku orijentiran (re)dizajn procesa i  modeliranje informacijskih sustava  na primjeru smart city usluga]]></title_hr><title_en><![CDATA[User-oriented process (re)design and information systems modelling – a case of smart city services]]></title_en><user_id>121</user_id><user_firstLast_name>Maja Ćukušić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-7625</code><acronim><![CDATA[MIS4SC]]></acronim><duration>01.01.2018 - 30.06.2023</duration><status>Završio</status><financ_value>129.186,85 eur</financ_value><scie_area_hr>Društvene znanosti, </scie_area_hr><scie_area_en>Social sciences, </scie_area_en><scie_field_hr>Ekonomija, Informacijske znanosti, </scie_field_hr><scie_field_en>Economy, Information sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Ekonomski fakultet]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Economics, Business and Tourism]]></institution_en><team_members_id>6889, 22717, 13037, 25307, 12620, 864836, 6863, </team_members_id><team_members_names><![CDATA[Mario Jadrić, Dino Pavlić, Tea Dragičević, Ivana Ninčević Pašalić, Vinko Muštra, Anton Manfreda, Tihomir Orehovački, ]]></team_members_names><keywords_hr><![CDATA[korisniku orijentiran (re) dizajn procesa, razvoj informacijskih sustava temeljen na podacima, smart city usluge, quadruple helix, prototipiranje IS-a]]></keywords_hr><keywords_en><![CDATA[user-oriented process (re)design, data driven development of information systems, smart city services, quadruple helix, informat. system prototyping]]></keywords_en><summary_hr><![CDATA[Projekt istraživačke grupe MIS4SC (Modelling information systems for smart city services) se fokusira na nekoliko povezanih područja koja se sva sadržajno odnose na informatizaciju poslovnih procesa. Ukratko – fokus istraživanja je korisniku orijentiran (re)dizajn procesa i razvoj povezanih, modernih informacijskih sustava baziranih na pametnim tehnologijama. Razvijeni koncepti i modeli će se testirati na konkretnim problemima i to u domeni servisa/rješenja za pametne gradove. Iz tog razloga, projektnim prijedlogom je predviđeno uključivanje svih relevantnih dionika prema quadruple helix modelu. Od rezultata se očekuju nove metodologije i modeli primjenjivi u privatnom i javnom sektoru, među kojima: metodologija za korisniku orijentiran (re)dizajn procesa, okvir za modeliranje informacijskih sustava temeljen na podacima korisnika (data driven developement) te provjereni modeli G2C/C2G smart city usluga spremni za implementaciju. Kao rezultat projekta očekuje se i povećanje znanja i kompetencija o istraživanju i provođenju korisniku orijentiranih pristupa unutar grupe i šire. Kao očekivani doprinos projekta, među ostalim, ističu se: (1)	Inovacije u praksama planiranja i modeliranja korisniku orijentiranih informacijskih sustava, (2)	Aktivna participacija i povećano zadovoljstvo korisnika informacijskih sustava (bilo u privatnom ili javnom sektoru),(3)	Partnerstvo u istraživanju i razvoju vezanom uz društvene izazove smart city koncepta, (4)	Poboljšanje kvalitete, učinkovitosti i prihvaćanja javnih usluga u G2C/C2G okruženju.]]></summary_hr><summary_en><![CDATA[The project of the research group MIS4SC (Modelling information systems for smart city services) focuses on a number of related areas in business process informatization / automation domain. In short - the research focuses on process (re)design and the development of modern information systems based on smart technologies. The concepts and the models developed within the framework of the project will be validated in a specific context - services/solutions for smart cities. For this reason, the project proposal foresees the inclusion of all relevant stakeholders in the four-tier helix model.As for the results, new methodologies and models applicable in the private and public sectors are expected, including: the methodology for user-oriented process (re)design, the framework for data-driven information system modelling and the development and validation of a number of G2C/C2G smart city models/services ready for deployment. As for the outcomes, among other things, the following could be expected:(1) Innovations in the planning and modelling practices of user-oriented, data-driven information systems,(2) Active participation and increased satisfaction of users of information systems (whether in the private or public sector),(3) Research and development partnerships tackling social challenges of the smart city concept,(4) Improving the quality, efficiency and acceptance of public services in the G2C / C2G environment.]]></summary_en></project><project>
<id>4763</id><title_hr><![CDATA[Nanostrukturirani tvrdi metali - Novi izazovi metalurgije praha]]></title_hr><title_en><![CDATA[Nanostructured  hardmetals - New challenges for Powder Metallurgy]]></title_en><user_id>4702</user_id><user_firstLast_name>Tamara Aleksandrov Fabijanić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-6538</code><acronim><![CDATA[NANO-PM]]></acronim><duration>15.05.2018 - 28.03.2023</duration><status>Završio</status><financ_value>308.950,20 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Metalurgija, Kemijsko inženjerstvo, Strojarstvo, </scie_field_hr><scie_field_en>Metallurgy, Chemical engineering, Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>7321, 5210, 22741, 24281, 855836, </team_members_id><team_members_names><![CDATA[Mateja Šnajdar Musa, Ivan Kumić, Marin Kurtela, Vedran Šimunović, Zoran Tomić Tomić, ]]></team_members_names><keywords_hr><![CDATA[metalurgija praha, nanosturkturirani tvrdi metali, nano prahovi, alternativna veziva, korozijska postojanost, PACVD ]]></keywords_hr><keywords_en><![CDATA[powder metallurgy, nanostructured hardmetals, nano powder, alternative binders, corrosion resistance, PACVD process]]></keywords_en><summary_hr><![CDATA[Projekt predviđa razvoj, istraživanje i inženjerstvo površina nanostrukturiranih tvrdih metala. Na početku projekta predviđa se zapošljavanje doktoranda i uspostava Laboratorija za metalurgiju praha čime se doprinosi jačanju kapaciteta prijavitelja. U Laboratoriju će se pripremati mješavine različitih polaznih karakteristika variranjem udjela i vrste matrice (Co, Ni, Fe..), karakteristika WC prahova i inhibitora rasta zrna (VC, NbC, TiC, TaC i Cr3C2) u cilju razvoja inovativnih nanostrukturiranih tvrdih metala s alternativnim vezivima i korozijski postojanih nanostrukturiranih tvrdih metala. Konsolidacija mješavina provest će se sinter-HIP postupkom i sinteriranjem plazmom na jednom od najznačajnih instituta u području istraživanja Fraunhoffer IKTS, Dresden, Njemačka. Istraživanje i analiza konsolidiranih uzoraka dovesti će do utvrđivanja utjecaja karakteristika polaznih mješavina i parametara konsolidacije na konačna svojstva nanostrukturiranih tvrdih metala. Nakon razvoja i detaljnog istraživanja predviđenih u prve tri godine projekta, u posljednje dvije godine istraživanja će se proširiti i na postupke prevlačenja nanostrukturiranih tvrdih metala. Prevlačenje će biti provedeno jednom od najsuvremenijih tehnologija inženjerstva površina, plazmom potpomognutog prevlačenja iz parne faze PACVD. Predviđa se nanošenje višeslojnih gradijentnih prevlaka kombinacijom slojeva TiN, TiCN i TiBN s ciljem postizanja inovativne prevlake poboljšanih svojstava na prethodno konsolidirane uzorke. Na temelju provedenih ispitivanja vrednovat će se provedeni postupak prevlačenja i optimirati parametri tehnološkog procesa. Donijet će se zaključi o primjenjivosti jedne od najsuvremenijih tehnologija inženjerstva površina, PACVD postupka, na nanostrukturirane tvrde metale. Predviđa se edukacija suradnika, sudjelovanje na konferencijama, objava znanstvenih radova u najutjecajnijim svjetskim časopisima, nabava kapitalne opreme te prijava projekta iz drugih izvora financiranja.  ]]></summary_hr><summary_en><![CDATA[The project predicts the development, research and surface engineering of nanostructured hardmetals. At the beginning of the project, the employment of Ph.D. student and the establishment of the Powder Metallurgy Laboratory is foreseen, thus contributing to the strengthening of the Faculty’s capacities. The mixtures would be prepared by varying the content and type of binder (Co, Ni, Fe ..), the characteristics of WC powders and grain growth inhibitors (VC, NbC, TiC, TaC and Cr3C2) in order to develop innovative nanostructured hardmetals with alternative binders and corrosion-resistant nanostructured hardmetals. The consolidation of the mixtures would be performed by sinter-HIP and plasma sintering process at Fraunhofer IKTS, Dresden, Germany, one of the most important institutes in the field. The research and analysis of the consolidated samples would be performed in order to determine the influence of starting mixture characteristics and consolidation parameters on the final properties. After the development and detailed research predicted in the first three years of the project, the research would be extended to the coating processes of nanostructured hardmetals in the last two years. Plasma assisted chemical vapor deposition PACVD, one of the most advanced surface engineering technologies, would be used. The multilayer gradient coatings by combination of TiN, TiCN and TiBN are planned for the purpose of creating an innovative coating with enhanced properties on previously consolidated samples.  On the basis of the carried research, the applied coating process will be evaluated and the process parameters would be optimized. The conclusions on the applicability of the PACVD process on the nanostructured hardmetals would be brought. Training of associates, conferences attending, publishing of scientific papers in the most influential world journals, procurement of capital equipment and submission of projects to other funding sources is predicted by the project.]]></summary_en></project><project>
<id>4765</id><title_hr><![CDATA[In silico i in vivo analiza transkriptoma stanične stijenke kvasca Saccharomyces cerevisiae i primjena dobivenih rezultata u konstrukciji novih biotehnoloških sojeva]]></title_hr><title_en><![CDATA[In silico and in vivo analysis of yeast Saccharomyces cerevisiae cell wall transcriptome and its application in construction of novel biotechnological strains]]></title_en><user_id>4377</user_id><user_firstLast_name>Igor Stuparevic</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-4411</code><acronim><![CDATA[SCCWTRANS]]></acronim><duration>01.12.2017 - 31.05.2023</duration><status>Završio</status><financ_value>295.069,35 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Biotehnologija, Prehrambena tehnologija, </scie_field_hr><scie_field_en>Biotechnology, Food technology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Food Technology and Biotechnology]]></institution_en><team_members_id>25073, 855426, </team_members_id><team_members_names><![CDATA[Ana Novačić, Nada Šupljika, ]]></team_members_names><keywords_hr><![CDATA[RNA, ncRNA, yeast, cell wall, transcriptome, Saccharomyces cerevisiae]]></keywords_hr><keywords_en><![CDATA[RNA, ncRNA, yeast, cell wall, transcriptome, Saccharomyces cerevisiae]]></keywords_en><summary_hr><![CDATA[Razvoj najnovijih tehnika sekvenciranja razotkrio je neočekivano veliku složenost transkriptoma eukariotskih stanica. Transkripcija koja se pojavljuje izvan definiranih genskih regija rezultira nastajanjem nekodirajućih RNA (ncRNA). Mi želimo ovim projektom rasvijetliti još uvijek podcjenjeni utjecaj i značaj ncRNA u regulaciji proteina staničnu stijenku kvasca Saccharomyces cerevisiae. Planiramo provesti bioinformatičku meta-analizu te in vivo analizu transkriptoma stanične stijenke kako bi prikupili informacije o transkriptima koji su potencijalno regulirani djelovanjem nekodirajućih RNA pri različitim uvjetima, različitim fazama rasta ili tijekom životnog ciklusa (mitoza i mejoza). Ovaj rad trebao bi rezultirati informacijama koje bi nam omogućile konstrukciju novih sojeva kvasca s izmjenjenim svojstvima stijenke, a što bi pak moglo unaprijediti brojne biotehnološke procese.]]></summary_hr><summary_en><![CDATA[Developments of deep sequencing techniques have unveiled an unexpected complexity of the eukaryotic transcriptome. Transcription occurring outside of annotated regions leads to the production of non-coding RNAs (ncRNAs). Here, we focus on an as yet underappreciated aspect of influence and significance of these ncRNAs to the cell wall of yeast Saccharomyces cerevisiae. We plan to conduct a bioinformatical meta-analysis and in vivo analysis of the cell wall transcriptome to gain knowledge about transcripts which are possibly regulated by non-coding RNAs under various conditions, different growth phases or along the life cycle (mitosis and meiosis). The outcome of this work should yield information that will enable us to construct novel yeast strains with modulated cell wall properties which could improve different biotechnological processes.   ]]></summary_en></project><project>
<id>4766</id><title_hr><![CDATA[ŽIVOT NA RIMSKOJ CESTI: komunikacije, trgovina i identiteti na rimskim cestama u Hrvatskoj od 1-8-.st.]]></title_hr><title_en><![CDATA[LIFE ON ROMAN ROAD: communications, trade and identities on Roman roads in Croatia from 1st – 8th CE ]]></title_en><user_id>2786</user_id><user_firstLast_name>Ivana Ožanić Roguljić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-9768</code><acronim><![CDATA[LRR]]></acronim><duration>01.01.2018 - 30.04.2023</duration><status>Završio</status><financ_value>149.578,61 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Arheologija, </scie_field_hr><scie_field_en>Archeology, </scie_field_en><institution_hr><![CDATA[Institut za arheologiju]]></institution_hr><institution_en><![CDATA[Institute of Archaeology in Zagreb]]></institution_en><team_members_id>22570, 22553, 22568, 22573, 855859, </team_members_id><team_members_names><![CDATA[Pia  Šmalcelj Novaković, Anita Rapan Papeša, valentina mantovani, Angelina Raickovic Savic, Jere Drpić, ]]></team_members_names><keywords_hr><![CDATA[rimska cesta, rimska keramika, rimska provincija Panonija,  rimska provincija Dalmacija, Avari]]></keywords_hr><keywords_en><![CDATA[Roman road, Roman ceramics, Roman province of Pannonia, Roman province of Dalmatia, Avari]]></keywords_en><summary_hr><![CDATA[Ceste u rimsko doba bili su arterije samog Carstva. Povezivali su provincije i gradove, a bez njih Rimljani nisu mogli niti osvojiti niti zadržati se na područjima kojima su vladali. Oni su bili sredstvo za pomicanje vojnih dužnosnika, civila i prijevoz robe. Rimske ceste stvorile su poveznice po kojima je u razdobljima nakon propasti Carstva organiziran život i osnivanje različitih naselja. Inženjerske i geodetske vještine Rimljana pružile su temelj mnogim današnjim rutama. Život na nekim rimskim cestama nastavio se i nakon pada Carstva i nije prestao do danas. Glavni cilj projekta je interpretacija svakodnevnog života na rimskoj cesti, od početka rimske vlasti do razdoblja propasti, akulturacije i integracije novih identiteta. Ovaj projekt nudi priliku za novu perspektivu: kako se život razvija oko rimskih cesta i staze tijekom glavne upotrebe cesta i nakon što je završio? Fokus projekta biti će razdijeljen na dva gledišta: 1. Život na rimskim cestama i stazama u rimsko doba, s obzirom na regionalne razlike (Lika - cesta Žuta Lokva, istočna Slavonija - Cibalae - Mursa), 2. Život neposrednih nasljednika (otok Korčula - cesta oko rimskih, kasnoantičkih i bizantske Lumbarde) i neizravnih sljedbenika (populacija kasnog Avarskog stanovništva iz 3 mjesta oko Cibala u istočnoj Slavoniji, bivša rimska pokrajina Panonnia Sirmiensis), rimska kulture u post-rimskom svijetu. U LRR projektu rimske ceste će se proučavati kao osnovna arterija rimskog svijeta, ali i kao metafora uvođenja, prihvaćanja i života rimskog načina života. Nakon propasti rimskog svijeta rimske ceste predstavljaju metaforu baštine i tradicije onoga što je nekada bilo veliko carstvo.]]></summary_hr><summary_en><![CDATA[Roads in Roman time were the arteries of the Empire itself. They connected provinces and cities, and without them the Romans could not have conquered and held onto the territories they ruled. They were means of moving military officials, civilians and to transport goods. Roman roads gave excellent links for organizing life and establishing various settlements in periods after the collapse of the Empire. Engineering and surveying skills of the Romans provided the basis for many of today&#39;s routes. Life on some Roman roads continued after the fall of the Empire and has not stopped until today. The main objective of the project is an interpretation of everyday life on the Roman road, from the beginning of the Roman rule to the period of decline, acculturation and integration of new identities. This project offers a chance for a new perspective: how does the life develop around Roman roads and a path during the main usage of the roads and after it’s over? Focus of the project will have different viewpoints: 1.Life on the Roman roads and paths in Roman times, considering the regional differences (Lika region – Road station Žuta Lokva;  Eastern Slavonia – Cibalae – Mursa route) 2.Life of direct successors (island Korčula – road around Roman, late Roman and Byzantine Lumbarda) and indirect followers (Late Avar population from 3 sites around Cibalae in Eastern Slavonia, former Roman province Panonnia Sirmiensis) of Roman culture in post-Roman world. In LRR project Roman roads will be studied as basic artery of Roman world but also a as a metaphors of introducing, accepting and living the Roman way of life. After the decline of Roman world Roman roads represent the metaphors of heritage and tradition of what was once a huge Empire.]]></summary_en></project><project>
<id>4773</id><title_hr><![CDATA[Metode za interpretaciju medicinskih snimki za detaljnu analizu zdravlja srca]]></title_hr><title_en><![CDATA[Medical Image Interpretation Methods for a Detailed Heart Health Analysis]]></title_en><user_id>21436</user_id><user_firstLast_name>Irena Galić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-4968</code><acronim><![CDATA[IMAGINEHEART]]></acronim><duration>01.03.2018 - 28.02.2023</duration><status>Završio</status><financ_value>151.703,76 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera Osijek, Fakultet elektrotehnike, računarstva i informacijskih tehnologija Osijek]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Electrical Engineering, Computer Science and Information Technology Osijek]]></institution_en><team_members_id>22468, 22473, 22467, 22558, 24844, 856226, 865511, </team_members_id><team_members_names><![CDATA[Hrvoje Leventić, Krešimir Romić, Zdravko Krpić, Tomislav Galba, Marija Habijan, Marin Benčević, Dario Mužević, ]]></team_members_names><keywords_hr><![CDATA[srce, segmentacija, analiza slike, simulacija, vizualizacija, programska biblioteka otvorenog koda, višestruka analiza zdravlja]]></keywords_hr><keywords_en><![CDATA[heart, segmentation, image analysis, simulation, visualisation, open source library, multiple health analysis]]></keywords_en><summary_hr><![CDATA[Kardiovaskularne bolesti uzrokuju godišnje više od 40% svih smrti u Europskoj Uniji. Metode snimanja u medicinske svrhe nezaobilazne su za utvrđivanje stanja kardiovaskularnog zdravlja neke osobe, a najčešće metode su računalna tomografija (CT) i magnetska rezonanca (MRI). Interpretacija tako prikupljenih medicinskih slika izrazito je ovisna o metodama računalne obrade, a potrebna programska podrška često je vrlo skupa i vezana uz proizvođača pojedinog uređaja, što otežava pristup takvom softveru manjim bolnicama i istraživačima.Osnovni cilj ovog projekta je razviti nove metode za analizu kardiovaskularne slike koje će moći odrediti što je više moguće kardiovaskularnih kvantifikacija srca iz što je moguće manje slika kako bi se postigla višestruka analiza kardiovaskularnog zdravlja. Takva analiza postići će se utvrđivanjem uzročno posljedičnih veza između određenih kvantifikacija i njihove dokazane utjecaje na kardiovaskularno zdravlje. Primjer kvantifikacija koje se mogu koristiti su: geometrija i volumen srca, geometrija bitnih arterija, morfologija aurikula lijeve pretklijetke, tok krvi kroz aortu, analiza srčane popustljivosti te kvantizacija epikardijalne masti. Odstupanje od normalnih vrijednosti gotovo svake od ovih kvanfitikacija faktor je rizika u razvoju neke od srčanih bolesti. Prepoznavanjem takvih odstupanja na vrijeme omogućit će se prepoznavanje potencijalnih rizika za zdravlje pacijenta što predstavlja fundamentalno poboljšanje u dijagnostici i tretmanu pacijenata.Konačan rezultat projekta bit će programska biblioteka otvorenog koda za analizu kardiovaskularnih slika, koja će sadržavate metode za sve kvantifikacije razvijene tijekom projekta. Bit će objavljena pod BSD licencom što će omogućiti suradnju i s industrijom i s akademskom zajednicom te će omogućiti istraživačima jednostavniju validaciju rezultata jer trenutno većina postojećih metoda nije javno dostupna istraživačima.]]></summary_hr><summary_en><![CDATA[Cardiovascular diseases are the main causes of more than 40% of all deaths in the European Union. Medical imaging techniques are unavoidable tools in the assesment of patient&#39;s cardiovascular health with the most often used methods being Computed Tomography (CT) and Magnetic Resonance Imaging (MRI).Interpretation of medical images acquired using these techniques depends on available image processing methods. Software packages implementing such methods are often both very expensive and proprietary, which means that small hospitals and research groups have difficulties purchasing such software.The main goal of this project is to develop a new method for the analysis of cardiovascular images which will be able to determine as many cardiovascular quantifications as possible using the lowest possible number of images, which will enable multiple analysis of cardiovascular health. Such analysis will determine the relationship between different hearh quantifications and risk factors for the development of cardiovascular diseases. The examples of quantifications that will be used are heart geometry and volume, geometry of important arteries, LAA morphology, blood flow through aorta, heart compliance, epicardial fat, etc. A discrepancy from reference values of each of these quantifications is a risk factor in the development of some heart disease.The final result of the project will be an open source library for cardiovascular image processing containing implementations of all methods developed within the scope of the project. The developed open source library will be BSD licensed fostering future cooperation with both academia and industry.]]></summary_en></project><project>
<id>4779</id><title_hr><![CDATA[Strukturiran ekološki uzgoj primjenom autonomnih robota u staklenicima]]></title_hr><title_en><![CDATA[Structured Ecological CULtivation with Autonomous Robots in Indoor Agriculture]]></title_en><user_id>21420</user_id><user_firstLast_name>Matko Orsag</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-4042</code><acronim><![CDATA[SPECULARIA]]></acronim><duration>01.06.2018 - 30.11.2023</duration><status>Završio</status><financ_value>238.224,91 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, Temeljne tehničke znanosti, </scie_field_hr><scie_field_en>Electrical engineering, Basic engineering sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>22738, 24179, 24172, 22725, 858415, 24260, 866665, 865777, 865776, </team_members_id><team_members_names><![CDATA[Antun Ivanović Ivanović, Marsela Polić, Juraj Oršulić, Marko Car, Jelena Tabak, Bruno Marić, Dean Martinović, Milena Jenić, Dario Stuhne, ]]></team_members_names><keywords_hr><![CDATA[Robotski sustavi, Bespilotne letjelice, Mobilna robotika, Podatni sustavi, Nelinearno upravljanje, Planiranje putanje, Planiranje zadataka ]]></keywords_hr><keywords_en><![CDATA[Robotic systems, Unmanned aerial vehicles, Mobile robotics, Compliant systems, Nonlinear control, Path planning, Path planning ]]></keywords_en><summary_hr><![CDATA[Cilj ovog projektnog prijedloga jest uspostaviti istraživačku grupu pri Fakultetu elektrotehnike i računarstva Sveučilišta u Zagrebu s istraživačkim fokusom na dvije posebno aktualne grane robotskog istraživanja, podatne manipulacije i heterogenih robotskih sustava. Predložene teme su trenutno jedne od najvećih pokretača istraživanja u robotici, te su pronašle svoju primjenu u različitim granama, počevši od medicine i industrije, pa sve do svemirske robotike. Budući da su ambiciozni praktični problemi, često najbolji pokretači istraživanja, za testiranje predloženih algoritama i ispitivanje sustava predložen je interdisciplinarni scenarij primjene heterogenog robotskog sustava u staklenicima organske poljoprivrede. Predloženim projektom planira se zaposliti i usavršiti doktorand i poslijedoktorand, odnosno educirati više generacija studenata fakulteta kroz rad na projektu. Uspješan nastavak rada na predloženoj temi, predviđen je, uz potporu Inovacijskog Centra Nikola Tesla, razvojem grupe u dva smjera: temeljno istraživanje i industrijsko primjenjivo istraživanje. Interdisciplinarnost projekta očituje se kroz horizontalnu temu poljoprivrede, a osigurana je potporom tvrtke Agrivi koja će pružiti svoje znanje i iskustvo.]]></summary_hr><summary_en><![CDATA[The main goal of this proposal is to establish a research group capable of performing internationally relevant research in the field of compliant robot control and heterogeneous robotic system in general, within the University of Zagreb Faculty of Electrical Engineering and Computing. These emerging topics are one of the most powerful drivers of robotic research. They are applied to various fields of research, including medical, industrial and even space robotics. Because, often enough practical problems are the best drivers of research, the project proposes validating these robotics research topics, in a scenario involving a heterogeneous robotics system utilized to help farmers in indoor organic agriculture. Project aim to employ and educate a PhD student and a Postdoctoral researcher, as well as offer undergraduate students an opportunity to work and learn on cutting edge robotics problems. Proposed three stage development of the group, in both basic technology research and industrial application, through the help of Innovation Center Nikola Tesla, will make sure the group continues the develop after the proposed project has ended. Interdisciplinary characteristic of the proposal is manifested through the application to agriculture and supported by a Croatian ICT company Agrivi, specialized in agriculture.]]></summary_en></project><project>
<id>4785</id><title_hr><![CDATA[Osnivanje i razvoj Centra za strukturno i nelinearno makroekonomsko modeliranje (MacroHub)]]></title_hr><title_en><![CDATA[Formation and Development of the Centre for Structural and Non-Linear Macroeconomic Modelling (MacroHub)]]></title_en><user_id>3635</user_id><user_firstLast_name>Tomislav Globan</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-6785</code><acronim><![CDATA[MACROHUB]]></acronim><duration>01.01.2018 - 31.12.2022</duration><status>Završio</status><financ_value>180.797,84 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, </scie_field_hr><scie_field_en>Economy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Ekonomski fakultet u Zagrebu]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Economics and Business]]></institution_en><team_members_id>3729, 3914, 3747, 3957, 4460, 3801, 3909, 25269, </team_members_id><team_members_names><![CDATA[Ozana Nadoveza, Marija Beg, Vladimir Arčabić, Tomislav Sekur, Lucija Rogić Dumančić, Tamara Slišković, Irena Raguž Krištić, Marin Levaj, ]]></team_members_names><keywords_hr><![CDATA[makroekonomija, strukturno modeliranje, istraživački centar, nelinearni modeli, evaluacija ekonomskih politika]]></keywords_hr><keywords_en><![CDATA[macroeconomics, structural modelling, research center, non-linear models, policy evaluation]]></keywords_en><summary_hr><![CDATA[Svrha projekta je osnovati i dugoročno razvijati moderni istraživački Centar za strukturno i nelinearno makroekonomsko modeliranje, koji bi u okviru Ekonomskog fakulteta u Zagrebu djelovao kao neovisna istraživačka jedinica - MacroHub. Istraživače MacroHuba činilo bi osam doktora ekonomskih znanosti te jedan doktorand. Svrha projekta ispunit će se ostvarenjem glavnih znanstvenih projektnih ciljeva: a) unaprjeđenjem znanstvenog kapaciteta uspostavljene istraživačke grupe; b) povećanjem istraživačke produktivnosti grupe; c) povećanjem istraživačke vidljivosti grupe; d) jačanjem znanstvene i stručne suradnje s inozemnim istraživačima. Na svjetskoj razini može se primijetiti nekoliko važnih trendova u makroekonomiji, od kojih se posebno ističu sve češća upotreba nelinearnih modela u teorijskim i primijenjenim istraživanjima te tzv. data rich pristup koji iskorištava dostupnost mnogobrojnih podataka. Uspostavljena istraživačka grupa će se organizirati oko tri istraživačke cjeline koje su usklađene s ovim trendovima. Prvi istraživački pravac fokusirat će se na razvoj i unaprjeđenje metodologije u makroekonomskim istraživanjima temeljenim na strukturnom (state-space) i nelinearnom (threshold) modeliranju te na njihovu primjenu u empirijskim istraživanjima. Unutar ovog pravca u sklopu projekta organizirat će se svjetski relevantna konferencija Society for Nonlinear Dynamics and Econometrics (SNDE) te će se razviti baza modela kojima će se istraživači MacroHuba koristiti kod primijenjenih istraživanja. Prvi pravac  komplementaran je drugom istraživačkom pravcu, usmjerenom na evaluaciju ekonomskih politika. U sklopu projekta izgrađeni modeli omogućit će  znanstvene temelje za bolji odabir među alternativnim ekonomskim politikama kroz vrednovanje njihovih učinaka. Treći istraživački pravac usmjerio bi se na razvoj novih i unaprjeđenje postojećih visokofrekventnih indikatora koji na jednostavan i lako razumljiv način opisuju dinamiku ekonomskih trendova u Hrvatskoj. ]]></summary_hr><summary_en><![CDATA[The purpose of the project is to set up and develop the Centre for Structural and Non-Linear Macroeconomic Modelling, which would act as an independent research unit (MacroHub) within the Faculty of Economics and Business in Zagreb. MacroHub research team comprises eight researchers with PhDs in the field of economics and one PhD student. The purpose of the project will be fulfilled by achieving several main scientific objectives: a) improving the scientific capacity of the formed research group; b) increasing the research productivity of the group; c) increasing the public visibility of the research group; d) strengthening the scientific and expert cooperation with foreign researchers. Several important trends can be observed on the global scene of macroeconomic research - more frequent use of non-linear models in theoretical and empirical studies and the data rich approach that utilises the availability of large volumes of data (big data). The formed research group will be organised around three research axes that are compliant to aforementioned global trends. The first research axis will focus on methodological developments and improvements in macroeconomic research based on structural (state-space) and non-linear (threshold) modelling and their application in empirical studies. Within this axis the research group will organise the globally prestigious conference of the Society for Nonlinear Dynamics and Econometrics (SNDE) and will develop the model database used by the MacroHub researchers in empirical papers. The first axis is complementary to the second research axis, focused on economic policy evaluation. Models built within the project will lay the groundwork for better policy implementation and evaluation of its effects. The third research axis will focus on the development of new and the improvement of existing high-frequency indicators, which describe and explain the dynamics of economic trends in Croatia in an easy and comprehensible fashion.]]></summary_en></project><project>
<id>4791</id><title_hr><![CDATA[Unaprjeđenje planiranja i gospodarenja zelenom infrastrukturom kroz participativno mapiranje kulturnih usluga ekosustava]]></title_hr><title_en><![CDATA[Improving green infrastructure planning and management through participatory mapping of cultural ecosystem services]]></title_en><user_id>7421</user_id><user_firstLast_name>Silvija  Krajter Ostoić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-1986</code><acronim><![CDATA[CULTUR-ES]]></acronim><duration>01.01.2018 - 31.12.2022</duration><status>Završio</status><financ_value>109.098,15 eur</financ_value><scie_area_hr>Biotehničke znanosti, Društvene znanosti, </scie_area_hr><scie_area_en>Biotechnical sciences, Social sciences, </scie_area_en><scie_field_hr>Šumarstvo, Sociologija, </scie_field_hr><scie_field_en>Forestry, Sociology, </scie_field_en><institution_hr><![CDATA[Hrvatski šumarski institut]]></institution_hr><institution_en><![CDATA[Croatian Forest Research Institute]]></institution_en><team_members_id>25104, 25107, </team_members_id><team_members_names><![CDATA[Martina Kičić, Ana Marija Marin, ]]></team_members_names><keywords_hr><![CDATA[zelena infrastruktura, percepcija građana, kulturne usluge ekosustava, participativno mapiranje, fokus grupe, upitnik, webGIS]]></keywords_hr><keywords_en><![CDATA[green infrastructure, citizen perception, cultural ecosystem services and disservices, participatory mapping, focus groups, survey, webGIS]]></keywords_en><summary_hr><![CDATA[Važnost zelene infrastrukture (ZI) za kvalitetu života u gradovima neprestano raste. Raste i broj ljudi koji žive u urbanim sredinama, pa ih je tako u Europi već sada tri četvrtine. ZI pruža brojne usluge ekosustava te ju je prepoznala i Europska komisija kao alat za prostorno planiranje koji je mnogostruko koristan za ispunjavanje ciljeva brojnih politika (prostornog planiranja, zaštite prirode i bioraznolikosti, prilagodbe na klimatske promjene i slično). Kulturne usluge ZI definiraju se prema Milenijskoj procjeni ekosustava kao „nematerijalne koristi ekosustava koje ljudima pružaju duhovno obogaćivanje, kognitivni razvoj, promišljanje, rekreacijske i estetske usluge“. Važnost istraživanja kulturnih usluga ekosustava ogleda se u činjenici da u Europi prevladavaju kulturni krajobrazi, a potražnja za njima u razvijenim zemljama sve više raste što će se nastaviti i u budućnosti. S druge strane u demokratskim društvima raste i potreba za većim uključivanjem javnosti u odlučivanje vezano za planiranje i gospodarenje ZI, dok izostanak javnosti često dovodi do otpora i protesta. Participativnim mapiranjem kulturnih usluga ZI prikupljaju se podatci o tome kako ljudi percipiraju ili koriste kulturne usluge ZI te je takva informacija korisna za daljnje prostorno planiranje i gospodarenje ZI. Cilj ovog projekta je na primjeru grada Zagreba identificirati, kvantificirati i mapirati kulturne usluge i štete na osnovu percepcije građana, otkriti što utječe na njihovu percepciju  te dati preporuke kako uključiti rezultate participativnog mapiranja u poboljšanje postojećeg sustava prostornog planiranja i gospodarenja ZI. U projektu će se koristiti kvalitativne i kvanititativne metode i alati (fokus grupe, upitnici, webGIS). Očekuje se da će projekt unaprijediti postojeća znanja o kulturnim uslugama i štetama od urbane ZI, naročito u smislu kvantificiranja neopipljivih koristi, ali i šteta, elemenata koji su često isključeni u dosadašnjim istraživanjima.]]></summary_hr><summary_en><![CDATA[With growing population in urban areas both globally and in Europe, importance of green infrastructure (GI) for quality of life is constantly increasing. GI provides various ecosystem services (ES) and is recognised by European Commission as a tool for achieving goals of various policies (spatial planning, nature and biodiversity conservation, climate change adaptation, etc.). According to the Millennium Ecosystem Assessment, cultural ES are defined as „the nonmaterial benefits people obtain from ecosystems through spiritual enrichment, cognitive development, reflection, recreation, and aesthetic experiences”. Importance of studying cultural ES is reflected in prevalence of cultural landscapes in Europe, demand for them is constantly increasing, and it will continue in future. On the other side, there is an increasing demand in democratic societies to include public in decision making with regard to planning and management of GI, while public exclusion from the process often leads to protests.  Participatory mapping of cultural ES collects data on how public perceive cultural ES from urban GI, which is useful input for future planning and management of urban GI. The goal of this project is to identify, quantify and map cultural ES and disservices from urban GI based on public perception, explore what affects the perception, and to give recommendation on how to include results of participatory mapping in current spatial planning and management of urban GI. Mix of qualitative and quantitative methods and tools will be used for that purpose (focus groups, survey, webGIS). The project will enhance knowledge on cultural ES and disservices from urban GI, especially in terms of quantification of non-material benefits, as well as disservices from GI since these are often excluded from research on cultural ES. ]]></summary_en></project><project>
<id>5790</id><title_hr><![CDATA[Razumijevanje popravka unakrsnog vezanja DNA-Protein in vivo koristeći zebricu kao istraživački model ]]></title_hr><title_en><![CDATA[Deciphering DNA-Protein Crosslink Repair in vivo using zebrafish model ]]></title_en><user_id>4272</user_id><user_firstLast_name>Marta Popović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-5258</code><acronim><![CDATA[DNAPRO]]></acronim><duration>01.02.2018 - 01.02.2023</duration><status>Završio</status><financ_value>246.997,15 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>1050, 25102, 27233, 29045, </team_members_id><team_members_names><![CDATA[Ivan Mihaljević, Christine Supina, Ivan Antičević, Cecile Otten, ]]></team_members_names><keywords_hr><![CDATA[DNA-protein unakrsna veza, DNA oštećenja, popravak DNA, in vivo, riba zebrica]]></keywords_hr><keywords_en><![CDATA[DNA-protein crosslink, DNA damage, DNA repair, in vivo, zebrafish]]></keywords_en><summary_hr><![CDATA[Unakrsna veza DNA-protein (eng. DNA-protein crosslink; DPC) je tip DNA oštećenja koje nastaje kao posljedica ireverzibilne kovalentne veze između DNA i proteina u prisutnosti endogenog ili egzogenog DPC inducirajućeg agensa. Endogeni DPC induceri su nusprodukti staničnog metabolizma poput oksidativnih radikala, aldehida i promjene u DNA strukturi, dok su primjeri egzogenih inducera ultraljubičasto i ionizirajuće zračenje te različiti kemijski agensi. DPC-i su česta DNA oštećenja i predstavljaju fizičku prepreku za sve DNA transakcije: replikaciju, transkripciju, rekombinaciju i popravak. Nemogućnost popravka DPC-ova uzrokuje genomsku nestabilnost i teške posljedice za organizam, uključujući preuranjeno starenje, neurodegenreaciju i pojavu tumora. Unatoč visokoj učestalosti pojave DPC-a, malo se zna o mehanizmu njihova popravka, jer se sve donedavno DPC popravak nije smatrao zasebnim mehanizom popravka DNA. Tijekom 2014. i 2016. god. nekoliko grupa je identificiralo nove stanične enzime, proteaze Wss1 i SPRTN, koje proteolizom DPC-a iniciraju njihov popravak. Otkriće proteolizno-ovisnog popravka DPC-a dovelo je do prepoznavanja DPC popravka kao zasebnog mehanizma popravka DNA oštećenja. Međutim, trenutno nije poznata regulacija cijelog mehanizma, niti je poznato koji drugi faktori sudjeluju u popravku, dok gotovo ništa nije poznato o mehanizmu DPC popravka in vivo. Stoga je glavni cilj predloženog projekta otkriti regulaciju puta popravka DPC-a in vivo koristeći ribu zebricu (Danio rerio) kao istraživački model. Koristit ćemo CRISPR/Cas9 gensku manipulaciju kako bi utišali ili mutirali gen(e) od interesa, a za koji pretpostavljamo da su uključeni u DPC popravak. Uloga pojedinih proteina (i njihovih kombinacija) u popravku DPC-a biti će analizirana nakon izolacije DPC-a iz transgeničnih embrija i odraslih jedinki zebrice. Također, konstruirati ćemo GFP reporter test sa transgenim ribama koji će omogućiti kvantifikaciju učinkovitosti DPC popravka in vivo. ]]></summary_hr><summary_en><![CDATA[A DNA-protein crosslink (DPC) is a type of DNA lesion where a protein becomes irreversibly covalently bound to DNA upon exposure to endogenous or exogenous crosslink inducers. Endogenous DPC inducers are products of normal cellular metabolism such as reactive oxygen species, aldehydes and DNA helical alterations, while exogenous inducers include UV light, ionizing radiation and various chemicals. DNA-protein crosslinks are one of the most common DNA lesions and present a physical blockage to all DNA transactions: replication, transcription, recombination and repair. If not repaired, DPCs cause genomic instability and adverse phenotypes in humans including premature aging, neurodegeneration and cancer. Despite the frequency and severe outcomes of DPC formation, DNA-protein crosslink repair (DPCR) has been sparsely studied, mostly because it has not been considered to be a separate DNA damage repair pathway until recently. In 2014 and 2016, several groups identified novel proteases, Wss1 and SPRTN, which initiate the removal of DPCs through the proteolytic digestion of crosslinked proteins. The discovery of proteolysis-coupled DPC repair lead to recognition of DPCR as a separate DNA damage repair pathway. However, we currently do not know how this pathway is orchestrated and which other factors are involved. Indeed, almost nothing is known of DPCR mechanisms in vivo. Therefore, within this project we aim to unravel the orchestration of the DPCR pathway in vivo using zebrafish as a well-characterized vertebrate model. We will use CRISPR/Cas9 gene manipulation tools to knock-out and mutate specific genes in zebrafish which we suspect are involved in DPC removal. The contribution of each protein (and their combinations) to DPCR will be quantified after DPC isolation from transgenic zebrafish embryos and adults. We will also generate a GFP reporter assay in transgenic fish which will enable the quantification of DPCR efficiency in vivo.]]></summary_en></project><project>
<id>5797</id><title_hr><![CDATA[Genotipska specifičnost pšenične trave (Triticum aestivum L.) visokonutritivnog prirodnog dodatka prehrani]]></title_hr><title_en><![CDATA[Genotype specificity of wheatgrass (Triticum aestivum L.) highly nutritional natural food supplement ]]></title_en><user_id>4574</user_id><user_firstLast_name>Andrijana Rebekić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-4292</code><acronim><![CDATA[WHEAT4GRASS]]></acronim><duration>01.01.2018 - 31.12.2022</duration><status>Završio</status><financ_value>231.840,20 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, Biotehnologija, </scie_field_hr><scie_field_en>Agriculture, Biotechnology, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Fakultet agrobiotehničkih znanosti Osijek]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Agrobiotechnical Sciences in Osijek]]></institution_en><team_members_id>22586, 1277, 22588, 22590, 25001, 25321, </team_members_id><team_members_names><![CDATA[Miroslav Lisjak, Katarina Mišković Špoljarić, Sunčica Guberac, vedran orkić, Sanja Grubišić, Marija Kristić, ]]></team_members_names><keywords_hr><![CDATA[pšenična trava, in vitro bioraspoloživost, antioksidacijska aktivnost, obogaćeni proizvod, biofortifikacija, nutraceutik]]></keywords_hr><keywords_en><![CDATA[wheatgrass, in vitro bioavailability, antioxidative activity, enriched food, biofortification]]></keywords_en><summary_hr><![CDATA[Podizanjem svijesti o važnosti zdrave prehrane sve je veća potražnja za funkcionalnom hranom. Najjednostavniji oblik funkcionalne hrane su namirnice koje prirodno imaju visok sadržaj tvari s pozitivim utjecajem na zdravlje ljudi. Takva namirnica je pšenična trava (Triticum aestivum L.) koja se u obliku svježeg soka ili praha koristi kao dodatak prehrani. Pšenična trava predstavlja mlade izdanke vrsta roda Triticum koji u velikim količinama sadrže klorofil, bioflavonoide, esencijalne aminokiseline, vitamine, minerale i antioksidante. Zbog svog sastava pšenična trava ima značajan pozitivna utjecaj na detoksikaciju organizma, jačanje imuniteta i cijeli niz akutnih oboljenja. Ciljevi predloženog istraživanja su (1) ispitati genotipsku specifičnost pšenične trave s obzirom na in vitro bioraspoloživost Zn, Fe, Se, Mn, Mg, Ca, K i Na, antioksidacijsku aktivnost te sadržaj kloroplastnih pigmenata, (2) ispitati utjecaj biofortifikacije cinkom i selenom na mineralni sastav, antioksidacijsku aktivnost i sadržaj kloroplasta, (3) izdvojiti genotipove pšenice za uzgoj pšenične trave koji će se moći preporučiti za direktnu uporabu kao dodatak prehrani, (4) ispitati antiproliferativni učinak ekstrakata pšenične trave na humanim tumorskim staničnim linijama. Ispitivanje genotipske specifičnosti provest će sa na 100 genotipova pšenice različitog podrijetla te će se izabrati genotipovi na kojima će se ispitivati utjecaj biofortifikacije selenom i cinkom na ispitivana svojstva pšenične trave. Antiproliferativni učinak ekstrakata pšenične trave ispitat će se na 5 humanih tumorskih staničnih linija. Predloženo istraživanje rezultirat će saznanjima značajnima hrvatskoj i međunarodnoj znanstvenoj zajednici, jer istraživanje pšenične trave ovakvog tipa i ovakvog obima još nije provedeno. Prema našim saznanjima, prva smo istraživačka skupina u Republici Hrvatskoj koje će se baviti istraživanjima na pšeničnoj travi.]]></summary_hr><summary_en><![CDATA[Raising awareness on the importance of healthy diet has increase demand for functional food. In their simplest form, functional food is a food that naturally possess substances that positively affect people&#39;s health. Wheatgrass (Triticum aestivum L.) is such food. Wheatgrass can be utilized as a dietary supplement in the form of fresh juice or powder made from young shoots of species of the genus Triticum. It contains chlorophyll, bioflavonoids, essential amino acids, vitamins, minerals and antioxidants in high quantities. Because of its composition, wheatgrass has a significant positive effect on detoxification of the body, strengthening of immunity and on a full range of acute illnesses. In the proposed study we will investigate (1) the genotype specificity of wheatgrass regarding the in vitro bioavailability of Zn, Fe, Se, Mn, Mg, Ca, K and Na, antioxidant activity and chloroplast pigment content, 2) the influence of zinc and selenium biofortification on mineral composition, antioxidant activity and content of chloroplast pigments; (3) select wheatgrass genotypes for cultivation and for recommendation for usage in the form of powder or fresh juice, (4) the antiproliferative effect of wheatgrass extracts on human tumor cell lines. A genotype specificity will be tested on a set of 100 wheat genotypes of different origin. Based on the results of genotype specificity testing, 10 genotypes will be selected for investigation of the effect of zinc and selenium biofortification on examined traits in wheatgrass. Investigation of the antiproliferative effect of wheat grass extracts will be performed on 5 human tumor cell lines. The proposed research will result in findings that are significant to the Croatian and international scientific community. Research of this type and this scope on wheatgrass has not been carried out yet. According to our knowledge, we are the first research group in the Republic of Croatia that will research nutraceutical properties of wheatgrass.]]></summary_en></project><project>
<id>5806</id><title_hr><![CDATA[Ars lignea: drvorezbarska umjetnička baština sjevernog Jadrana od 1300. do 1600. godine]]></title_hr><title_en><![CDATA[Ars lignea: the Woodcarving Art Heritage of the North Adriatic from 1300 until 1600]]></title_en><user_id>12940</user_id><user_firstLast_name>Barbara Španjol-Pandelo</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-6356</code><acronim><![CDATA[ArsLigneAdriatica]]></acronim><duration>01.03.2018 - 28.02.2021</duration><status>Završio</status><financ_value>82.117,86 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Povijest umjetnosti, Povijest, Znanost o umjetnosti, </scie_field_hr><scie_field_en>Art history, History, Arts, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Filozofski fakultet u Rijeci]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>22693, 12968, 28176, 5555, </team_members_id><team_members_names><![CDATA[Saša Potočnjak, Petra Predoević Zadković, Kosana Jovanović, Matko Matija Marušić, ]]></team_members_names><keywords_hr><![CDATA[drvorezbarstvo, drvena skulptura, Kvarner, Istra, srednji vijek, renesansa]]></keywords_hr><keywords_en><![CDATA[woodcarving, wooden sculpture, Kvarner bay, Istria, Middle Ages, Renaissance]]></keywords_en><summary_hr><![CDATA[U razdoblju između 1300. i 1600. godine drvorezbari su imali važan udio u oblikovanju i razvoju umjetničke produkcije u Europi. no na prostoru sjevernog Jadrana njihova je uloga u povijesno-umjetničkim istraživanjima često bila zanemarena. Sačuvane umjetnine važan su dio sakralnih prostora i svjedoče nam o važnosti njihove uloge u crkvenim obredima. Promjene u liturgiji uvjetovali su nestanak značajnog dijela drvenih predmeta sakralne namjene, no dio baštine se ipak sačuvao. Zbog osjetljivog drvenog materijala sklonog propadanju, ali i zbog promjena estetike sačuvan je manji broj predmeta svjetovne namjene. Ipak, oni nam govore u prilog značaja drvorezbarstva u svakodnevnom životu, a mogu nam biti važan izvor podataka o brojnim drvorezbarskim radionicama koje su zadovoljavale potrebe stanovništva i u duhovnom i u svjetovnom životu. Osnovni cilj projekta je omogućiti nove spoznaje o drvorezbarstvu i drvorezbarima koji su djelovali na prostoru sjevernog Jadrana odnosno Kvarnera, kvarnerskih otoka i Istre u razdoblju od 1300. do 1600. godine. Većina građe gotovo je potpuno zanemarena te je istraživanje nužno kako bi se u cjelovitom katalogu objedinili svi podaci. Važan dio istraživanja bit će pozicioniranje djelatnosti kasnosrednjovjekovnih i renesansnih drvorezbara u širi kontekst europske umjetnosti, u prvom redu drvorezbarske djelatnosti ostvarene na prostoru Apeninskog poluotoka i Srednje Europe. Rezultat osnovnog cilja projektnog prijedloga je cjeloviti uvid, baziran na temeljnim istraživanjima, o drvorezbarstvu i drvorezbarima koji su djelovali na prostoru sjevernog Jadrana, kako bi se pridonijelo valorizaciji i boljem očuvanju i čuvanju drvene skulpture i namještaja obuhvaćenog u predloženom projektnom prijedlogu. Također, rezultat osnovnog cilja projektnog prijedloga je uspostavljena istraživačka grupa mladih istraživača koji će razvijati istraživačku metodologiju i promicati značaj drvorezbarske baštine radi njene zaštite i društvene valorizacije. ]]></summary_hr><summary_en><![CDATA[Between 1300 and 1600 woodcarvers played an important role in shaping and developing artistic production in Europe. However, in the area of the northern Adriatic their role in art historical research has often been neglected. The preserved works of art are an important part of the sacred spaces and testify the importance of their role in liturgy. However, changes in the liturgy caused the disappearance of a significant part of wooden objects, but part of the sacral heritage has been preserved. Due to the susceptibility of wooden material to decay, but also due to the aesthetics changes, not many secular objects have been preserved. Nevertheless, both sacral and secular works of art stress the significance of woodcarving in the everyday life. Also they are an important source of information on numerous woodcarving workshops that had produced works of art for sacral and secular life. The main objective of the project is to provide the new insights into woodcarvings and woodcarvers that have been working in the area of the northern Adriatic, i.e. Kvarner bay, Kvarner islands and Istria from 1300 to 1600. Most of the woodcarvings have been neglected and the research is necessary in order to include all data in one complete catalogue. An important part of the research will be to put the activities of late medieval and Renaissance woodcarvers in the context of European art, firstly of woodcarving activities carried out on the Apennine Peninsula and Central Europe. The result of the overall objective would be a complete insight on woodcarvings of the northern Adriatic in order to contribute to valorisation and better preservation of wooden sculptures and furniture. Also, the result would be the establishment of a research group of young researchers who will develop research methodology and promote the importance of woodcarving heritage in order to protect it and evaluate it.  ]]></summary_en></project><project>
<id>6810</id><title_hr><![CDATA[Otiskivanje, kvaliteta i uporabljivost podloga s ne-drvnim vlakancima]]></title_hr><title_en><![CDATA[Printability, quality and utilization of substrates with non-wood fibres]]></title_en><user_id>19535</user_id><user_firstLast_name>IRENA BATES</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-2573</code><acronim><![CDATA[NWF prints quality]]></acronim><duration>08.01.2018 - 07.06.2023</duration><status>Završio</status><financ_value>119.529,88 eur</financ_value><scie_area_hr>Tehničke znanosti, Biotehničke znanosti, </scie_area_hr><scie_area_en>Technological sciences, Biotechnical sciences, </scie_area_en><scie_field_hr>Grafička tehnologija, Prehrambena tehnologija, </scie_field_hr><scie_field_en>Graphics technology, Food technology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Grafički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Graphic Arts]]></institution_en><team_members_id>22695, 22688, 19527, 19976, 25409, </team_members_id><team_members_names><![CDATA[Katja Petric Maretić, Maja  Rudolf, Ivana Plazonić, Mia Kurek, Valentina Radić Seleš, ]]></team_members_names><keywords_hr><![CDATA[tiskovnost, kvaliteta reprodukcije, boje, migracija, stabilnost, ne-drvna vlakanca, papir]]></keywords_hr><keywords_en><![CDATA[printability, quality of reproduction, inks, migation, resistance, non-wood fibres, paper]]></keywords_en><summary_hr><![CDATA[U papirnoj industriji najkorištenija sirovina su drvna celulozna vlakanca čija se dostupnost drastično smanjila zbog neracionalne eksploatacije šumskih površina. Istraživanja u ovom projektnom prijedlogu biti će usmjerena na procjenu mogućnosti korištenja vlakanaca slame žitarica u izradi inovativnih tiskovnih podloga te njihova uporabljivost za novi grafički proizvod. Slama žitarica kao alternativa drvnoj sirovini logično se nameće jer jeftin je i godišnje obnovljiv izvor vlakanaca. S obzirom na aktualnu problematiku nedostatka drvne sirovine i potrebe za novim izvorima vlakanaca načinit će se laboratorijski papiri s ne-drvnim vlakancima i otiskivati najzastupljenijim tehnikama tiska u cilju procjene njihove upotrebljivosti za određeni grafički proizvod. Fizikalno-kemijska svojstva boje ovisna su o različitim tehnikama tiska kako bi se postigla kvalitetna reprodukcija višebojne slike i teksta. Navedene tehnike tiska koriste drugačije boje prema viskoznosti, konzistenciji, ljepljivosti i koheziji stoga je potrebno ispitati i evaluirati prihvaćanje boje na načinjene laboratorijske papire kao i prihvaćanje boje na prethodno otisnutu boju. Mogućnost otiskivanja i uporabljivost papira s ne-drvnim vlakancima promatrat će se na laboratorijskim papirima nanošenjem najzastupljenijih konvencionalnih i modernih boja. Temeljem kvalitativnih parametara: penetracije i migracije boje u podlogu, zrnatosti i nejednoličnosti reprodukcije tonova, kvalitete reprodukcije tona cijan, magente, žute i crne boje, te prihvaćanja boje na prethodnu otisnutu boju i ukupne količine boje na tiskovnoj podlozi definirati će se mogućnost otiskivanja na laboratorijskim uzorcima papira. Dok će se upotrebljivost tih otiska definirati na temelju stabilnosti na kemijske agense, pritisak, temperaturu, vlagu i UV zračenje. Ostvarivanjem ovog projektnog prijedloga stvoriti će se novi grafički proizvod, koji će unaprijediti područje grafičke tehnologije pametnim iskorištenjem obnovljivih resursa.]]></summary_hr><summary_en><![CDATA[In the paper industry a cellulose fibres are the main raw material, which availability for utilization in the paper industry has been drastically reduced due to irrational exploitation of this natural resource. Assessing the possibility of using straw in form of the pulp for the production of innovative paper-based printing substrates and their usability for the new graphical product is the aim of this project proposal. The straw comparing to wood raw material is a logical alternative because it is a cheap and annually renewable source of fibres. Considering the lack of wood raw materials and the need for new fibre sources, laboratory produced papers will be made using different shares of straw pulp, which will be printed with the most widely used printing techniques in order to estimate their usability. Physical and chemical properties of inks depend on different printing techniques to achieve high quality reproduction. The aforementioned printing techniques use different inks in terms of their viscosity, consistency, adhesiveness and cohesion, therefore it is necessary to examine and assess the acceptance of inks on substrate as well as the ink trapping.The printability of papers containing non-wood fibres and the paper’s usability will be observed on laboratory produced papers by applying the most commonly used conventional and contemporary inks.Based on the qualitative parameters: the penetration and migration of printing ink into the substrate, graininess and mottling, the quality of the tone reproduction, trapping and the total amount of inks on the substrate will be defined as the possibility of printing on laboratory produced sheets. While the usability of these prints will be defined on the basis of stability in relation to chemical agents, pressure, temperature, humidity and UV radiation. By realizing this project proposal, a new graphical product will be created, which will advance the graphic technology with smart utilization of renewable resources. ]]></summary_en></project><project>
<id>6811</id><title_hr><![CDATA[HRVATSKI MONITOR NASILJA - Istraživanje pojavnih oblika, uzroka i procesuiranja delinkventnog nasilja s fokusom na zaštiti posebno ranjivih skupina žrtava]]></title_hr><title_en><![CDATA[CROATIAN VIOLENCE MONITOR - A Study of the Phenomenology, Etiology, and Prosecution of Delinquent Violence with Focus on Protecting Particularly Vulnerable Groups of Victims]]></title_en><user_id>21439</user_id><user_firstLast_name>Reana Bezic</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-8876</code><acronim><![CDATA[CroViMo]]></acronim><duration>01.03.2018 - 31.12.2025</duration><status>U tijeku</status><financ_value>181.195,64 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Pravo, </scie_field_hr><scie_field_en>Law, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Pravni fakultet u Zagrebu]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Law]]></institution_en><team_members_id>21441, 6366, 22507, 22482, 6127, 22461, 21442, 25465, 23551, 17736, 4770, </team_members_id><team_members_names><![CDATA[Ruža Karlović, Goran Livazović, Pero Mihaljević, Marko Mrakovčić, Lucija Sokanović Sokanović, Petra Šprem, Igor Vuletić, Mirjana Kondor-Langer, Karlo Bojčić, Vedran Recher, Marija Baković, ]]></team_members_names><keywords_hr><![CDATA[kriminologija, nasilje, prevencija nasilja, ubojstvo, kibernetičko uznemiravanje, Hrvatska]]></keywords_hr><keywords_en><![CDATA[criminology, violence, violence prevention, homicide, cyber harassment, Croatia]]></keywords_en><summary_hr><![CDATA[Projekt CroViMo ima za cilj uspostavljanje multidisciplinarne grupe mladih znanstvenika koji će provoditi inovativna istraživanja nasilja u Hrvatskoj kroz svoj „Laboratorij za analizu nasilja“. Glavni cilj istraživanja je empirijsko i normativno snimiti te analizirati fenomenologiju, etiologiju i procesuiranje delinkventnog nasilja u Hrvatskoj, pri čemu će naglasak biti na posebno ranjivim skupinama žrtava sa svojim vrlo specifičnim i različitim potrebama zaštite od nasilja. Te posebno ranjive skupine uključuju: djecu; žene i djevojke; starije; manjine, strance, izbjeglice i migrante; osobe u institucionaliziranoj skrbi; osoblje rizičnih zanimanja; i LGBT. Za razliku od uobičajenog tzv. „mainstream“ istraživanja nasilja, koje se uglavnom fokusira na specifične (pod)vrste nasilja i/ili skupine žrtava izvan općeg konteksta delinkventnog nasilja, CroViMo će prvo provesti izvorno istraživanje ukupnog delinkventnog nasilja, prije no što se fokusira na njegove pojedine (pod)vrste. Ovaj holistički pristup temelji se na pretpostavci da proučavanje određene (pod)vrste nasilja, bez empirijskih podataka o općem nasilnom kontekstu dovodi do fragmentarnih, a potencijalno i iskrivljenih shvaćanja pojedinih promatranih (pod)vrsta nasilja. Glavni zadatak CroViMo biti će razviti i testirati novu inovativnu klasifikaciju delinkventnog nasilja, „autentični sustav klasifikacije nasilja”, koja neće podlijegati normativnim ograničenjima trenutnih klasifikacija, nego će biti usredotočena isključivo na sam fenomen nasilja. Takav sustav klasifikacije mogao bi označiti prekretnicu u području istraživanja nasilja. Ovaj ambiciozni plan rada, ukoliko bi bio uspješno proveden, trebao bi dugoročno osigurati razvoj projekta CroViMo u prepoznatljiv nacionalni, regionalni i europski „Laboratorij za analizu nasilja“, te privući daljnje nacionalne i međunarodne znanstvene suradnje i uspješne nove kolaborativne projektne prijave, s velikim potencijalom za prijenos znanstvenih spoznaja u praksu.]]></summary_hr><summary_en><![CDATA[The CroViMo project aims at setting up a multidisciplinary nationwide research group of young researchers for conducting innovative violence research in Croatia through its&#39; “Violence Research Lab”. The central research objective is to empirically and normatively capture and analyse the phenomenology, etiology, and prosecution of delinquent violence in Croatia, with special focus on particularly vulnerable groups of victims with their very specific and diverse needs for protection from violence. These particularly vulnerable groups include: children; women and girls; the elderly; minorities, foreigners, refugees and migrants; persons in institutional custody; risky professions’ personnel; and LGBT. In contrast to ‘mainstream’ violence research, which predominantly focuses on specific (sub)types of violence and/or victim groups outside the overall context of general delinquent violence, CroViMo will conduct genuine foundational research on the total of delinquent violence, before focusing on its’ certain (sub)types. This broad approach is based on the premise that the study of certain (sub)types of violence without empirical data on the overall violent context leads to fragmentary, and potentially distorted understandings of the (sub)types in question. The main task of CroViMo will be to develop and test an innovative new classification of delinquent violence, the “genuine violence classification system” that will blend out the normative constraints of current mainstream classifications and focus strictly on the violence itself. Such a classification system might be a breakthrough in violence research. This ambitious work plan, if implemented successfully, should in the long run facilitate CroViMo’s development into a recognisable national, regional, and European “Violence Research Lab”, attracting further national and international scientific cooperation and successful joint funding applications, with a huge potential for dissemination of findings into practice.]]></summary_en></project><project>
<id>6824</id><title_hr><![CDATA[Derivati harmina kao potencijalni antimalarici]]></title_hr><title_en><![CDATA[Harmine derivatives as potential antimalarial agents]]></title_en><user_id>6183</user_id><user_firstLast_name>Zrinka Rajić Džolić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-5160</code><acronim><![CDATA[CLICKforMALARIA]]></acronim><duration>01.04.2018 - 30.06.2023</duration><status>Završio</status><financ_value>233.193,97 eur</financ_value><scie_area_hr>Prirodne znanosti, Biomedicina i zdravstvo, </scie_area_hr><scie_area_en>Natural sciences, Biomedicine and health sciences, </scie_area_en><scie_field_hr>Farmacija, Kemija, </scie_field_hr><scie_field_en>Pharmaceutical sciences, Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Farmaceutsko-biokemijski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Pharmacy and Biochemistry]]></institution_en><team_members_id>6174, 6538, 22512, 4758, 22514, 25221, 25308, 21322, 865248, 866031, </team_members_id><team_members_names><![CDATA[Ivana Perković, Kristina Pavić, Tamirat Gebru Woldearegai, Hrvoje Rimac, Diana Fontinha, Marina Marinović, Goran Poje, Maja Beus, Ana Penava, Lucija Bilandžija, ]]></team_members_names><keywords_hr><![CDATA[malarija, harmin, sinteza, antimalarijsko djelovanje, citotoksičnost, studije metabolizma]]></keywords_hr><keywords_en><![CDATA[malaria, harmine, synthesis, antimalarial activity, citotoxicity, metabolic studies]]></keywords_en><summary_hr><![CDATA[Malarija je smrtonosna bolest tropskih i subtropskih krajeva koja se prenosi ubodom komarca, a uzrokovana je parazitima roda Plasmodium. Cjepivo protiv malarije ne postoji, kao ni učinkovito uništavanje prijenosnika malarije. Osim toga, pojava otpornosti vrsta Plasmodium na postojeće lijekove dovodi do neučinkovitosti sadašnje terapije i zahtijeva otkriće lijekova s novim mehanizmima djelovanja. Alkaloidi b-karbolinskog tipa prisutni su u biljkama Peganum harmala i Eurycoma longifolia, koje se više od 2 tisućljeća koriste u tradicionalnoj kineskoj medicini za liječenje malarije i karcinoma. Djelatne supstancije ekstrakta biljke su alkaloidi harmin, harmalin, harmalol i harman. In vitro i in vivo studije pokazale su da harmin posjeduje snažno antimalarijsko djelovanje. Njegov mogući mehanizam djelovanja je inhibicija proteina toplinskog šoka 90 iz P. falciparum, koji je nužan za normalni razvoj parazita i ima važnu ulogu u razvoju rezistencije na postojeće antimalarike. U ovom projektu predviđeno je dizajniranje i sinteza knjižnice spojeva, koji se sastoje od harmina i 1) derivata cimetne kiseline (harmicini), 2) poznatih antimalarika: klorokina i meflokina (harmikini) i 3) ferocena (harmoceni). U sva tri tipa predviđenih spojeva poveznica će biti 1H-1,2,3-triazol, koji se pokazao korisnim u pripravi različitih biološki aktivnih spojeva. Predviđeni spojevi pripravit će se uobičajenim metodama sintetske organske kemije, te korištenjem modernih pristupa, &#39;&#39;click&#39;&#39; kemije i sinteze uz pomoć mikrovalova.Sintetiziranim spojevima ispitat će se antimalarijsko djelovanje in vitro, na eritrocitnu i hepatocitnu fazu plazmodija, te citoksično djelovanje na humane stanične linije. Uz to, provest će se studije metabolizma biološki aktivnih spojeva.Konačni rezultat projekta biti će novi spojevi učinkoviti protiv rezistentnih sojeva roda Plasmodium. Najaktivniji spojevi biti će polazišna točka za budući razvoj inovativnih lijekova.]]></summary_hr><summary_en><![CDATA[Malaria is a deadly mosquito-borne tropical and subtropical disease, caused the parazite of the genus Plasmodium. There is neither available vaccine, nor reliable vector control. In addition, Plasmodium is developing resistance to the existing therapy, which urges the discovery of novel drugs with new mechanisms of action.Alkaloids of b-carboline type are present in the medicinal plants Peganum harmala and Eurycoma longifolia, which have been used in the traditional Oriental medicine for the treatment of cancer and malaria. The active ingredients were identified as harmine, harmaline, harmalol and harman. In vitro and in vivo studies have proven harmine&#39;s antimalarial activity. Its possible mechanism of action is selective inhibition of P. falciparum heat shock protein 90, which is crucial for the parazite development and may play a major role in drug resistance. In the proposed project we decided to focus on the design and synthesis of a compound library, comprising harmine and 1) cinnamic acid moiety (harmicines), 2) known antimalarial drugs: chloroquine or mefloquine (harmiquines) and 3) ferrocene scaffold (harmocenes). The final compounds will incorporate 1H-1,2,3-triazole scaffolds, which proved to be useful in the synthesis of various biologically active compounds. Standard methods of synthetic organic chemistry, as well as modern approaches, such as click chemistry and microwave assisted synthesis will be employed. Antimalarial activity of the prepared compounds will be evaluated in vitro on both erythrocytic and hepatic stage of the Plasmodium, as well as cytotoxycity against human cell lines. In addition, metabolism studies for the biologically active compounds will be performed. As a final result, we will provide new candidate therapeutics against drug-resistant malaria parasite. The most active compounds will offer a valuable starting point for future development of innovative medicines.]]></summary_en></project><project>
<id>6829</id><title_hr><![CDATA[Istraživanje procesa koji se odvijaju u vodoopskrbnim sustavima]]></title_hr><title_en><![CDATA[Examination of the processes occurring in the drinking water distribution systems ]]></title_en><user_id>4429</user_id><user_firstLast_name>Magdalena Ujević Bošnjak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-3088</code><acronim><![CDATA[ProVoda]]></acronim><duration>01.04.2018 - 31.03.2023</duration><status>Završio</status><financ_value>341.138,31 eur</financ_value><scie_area_hr>Prirodne znanosti, Biomedicina i zdravstvo, </scie_area_hr><scie_area_en>Natural sciences, Biomedicine and health sciences, </scie_area_en><scie_field_hr>Kemija, Biologija, Javno zdravstvo i zdravstvena zaštita, </scie_field_hr><scie_field_en>Chemistry, Biology, Public health and health services, </scie_field_en><institution_hr><![CDATA[Hrvatski zavod za javno zdravstvo, Zagreb]]></institution_hr><institution_en><![CDATA[Croatian National Institute of Public Health, Zagreb]]></institution_en><team_members_id>19803, 22532, 4674, 25227, </team_members_id><team_members_names><![CDATA[Krunoslav Capak, Jurica  Štiglić, Mirjana Novak, Livia Kurajica, ]]></team_members_names><keywords_hr><![CDATA[voda za piće, vodoopskrbni sustav, nusprodukti dezinfekcije, arsen, olovo, nikal, naslage u cijevima, otpuštanje, biofilm, voda i zdravlje]]></keywords_hr><keywords_en><![CDATA[drinking water, distribution systems, disinfection by-products, arsenic, lead, nickel, pipe scales, release, biofilms, water and health]]></keywords_en><summary_hr><![CDATA[Fizički, kemijski i biološki procesi koji se odvijaju u vodoopskrbnim sustavima znatno utječu na kvalitetu vode koja se isporučuje potrošačima. Gotovo svi vodoopskrbni sustavi sadrže naslage krutih tvari. Prethodna istraživanja pokazala su da naslage bogate željezom u distribucijskim sustavima mogu akumulirati elemente u tragovima, čak i kada su oni prisutni u vodi za piće u koncentracijama nižim od maksimalno dopuštenih koncentracija, s mogućnošću naknadnog otpuštanja i transporta prema potrošačima u razdobljima velikog protoka. Procesi koji se odvijaju u vodoopskrbnim sustavima vrlo su složeni, a na njih utječu biotički i abiotički čimbenici. Promjene u sustavu, na primjer početak korištenja dezinfekcijskog sredstva ili prelazak na drugu vrstu dezinfekcijskog sredstva, utječu na kemizam vode i mogu uzrokovati lošiju kvalitetu vode kod potrošača nego li je bila na izlazu iz postrojenja za obradu vode.  Osim toga, pokazalo se da nusprodukti dezinfekcije, kao što su halooctene kiseline (HAA), koji nisu regulirani u Europskoj uniji, ako su prisutni s trihalometanima (THM), potiču otpuštanje kontaminanata iz naslaga u vodenu fazu. Glavni je cilj ovog projekta istražiti fizikalno-kemijske i mikrobiološke procese koji se odvijaju u vodoopskrbnim sustavima u različitim uvjetima i utječu na otpuštanje kontaminanata iz materijala nakupljenog u vodoopskrbnoj mreži. Istraživanje će biti provedeno u tri vodoopskrbna sustava u Hrvatskoj s različitim sastavom voda. Uzorkovat će se te  kemijski i mikrobiološki analizirati uzorci vode i naslaga. Također će se provesti laboratorijski eksperimenti kako bi se dalje proučavali uočeni procesi. Rezultati će biti statistički obrađeni, a procesi koji se odvijaju u vodoopskrbnim sustavima bit će modelirani. Kako je opskrba zdravstveno ispravnom vodom za piće temelj javno-zdravstvene zaštite stanovništva, izvršit će se procjena rizika za ljudsko zdravlje vezana uz prisutnost nusprodukata dezinfekcije (THM i HAA) u vodi za piće.]]></summary_hr><summary_en><![CDATA[Physical, chemical, and biological processes that take place in the distribution system largely influence water quality reaching consumer’s tap. Almost all drinking water distribution systems (DWDS) contain solids. Previous research showed that iron-rich deposits in the distribution systems can accumulate trace elements, even present in the drinking water below maximum allowable limit, with potential for subsequent removal and transport to consumers at periods of high flow. The processes occurring in the drinking water distribution systems are very complex and influenced by biotic and abiotic factors. Switching from nondisinfection to disinfection, or changing the type of disinfectant used will influence water chemistry and can cause water quality deterioration at the consumer tap when compared to the original water produced at the treatment plant. Furthermore, it is shown that in the EU, nonregulated disinfection by-products such as haloacetic acids (HAA) if present with trihalomethane (THM) promote release of contaminants from scales  in finished water. The main goal of this project is to understand the physicochemical and microbiological processes that occur in the DWDS under various conditions and influence release of contaminants from the material retained in the network. Research will be conducted in the three DWDS in Croatia exhibiting different water compositions, from which water and solid samples will be taken and chemically and microbiologically analyzed. Laboratory experiments will be conducted to study observed processes in further depth. The results will be statistically processed, whereas the processes taking place in DWDS will be modelled. Since the provision of safe drinking water is essential from the public health point, the assessment of public health risks related to presence of the disinfection by products (THMs and HAAs) in the drinking water will be done.]]></summary_en></project><project>
<id>6833</id><title_hr><![CDATA[Kulturni krajolik – model valorizacije, zaštite, upravljanja i korištenja kulturne baštine]]></title_hr><title_en><![CDATA[The Cultural Landscape - A Model for Valorisation, Protection, Management and Use of Cultural Heritage]]></title_en><user_id>22523</user_id><user_firstLast_name>Igor Kulenović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-2152</code><acronim><![CDATA[ProHeritage]]></acronim><duration>01.01.2018 - 31.12.2022</duration><status>Završio</status><financ_value>115.353,57 eur</financ_value><scie_area_hr>Humanističke znanosti, Društvene znanosti, </scie_area_hr><scie_area_en>Humanities, Social sciences, </scie_area_en><scie_field_hr>Arheologija, Sociologija, Povijest, </scie_field_hr><scie_field_en>Archeology, Sociology, History, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zadru]]></institution_hr><institution_en><![CDATA[University of Zadar]]></institution_en><team_members_id>22524, 22536, 19329, 17616, 19351, 22581, 17610, 18940, 25014, 5733, 861527, </team_members_id><team_members_names><![CDATA[Neda Kulenović Ocelić, Filomena Sirovica, Vedrana Glavaš, Gabrijela Vidić, Martina Dubolnić Glavan, Šime Vrkić, Vinko BAKIJA, Miro Stošić, Denis Radoš, Uroš Stepišnik, Sara Iglić, ]]></team_members_names><keywords_hr><![CDATA[kulturna baština, kulturni krajolik, karakterizacija povijesnog krajolika, GIS, valorizacija, zaštita, upravljanje]]></keywords_hr><keywords_en><![CDATA[cultural heritage, cultural landscape, HLC, valorisation, protection, management]]></keywords_en><summary_hr><![CDATA[Arheologija je u posljednjih 20-ak godina doživjela nekoliko transformacija. Osim epistemoloških i teorijskih zaokreta arheologiju su oblikovale nove tehnologije i novi mediji koji su stvorili nove perspektive i područja rada. Jedna od najvećih transformacija koja se je dogodila u arheologiji je razvoj arheologije krajolika. Ovaj zaokret su popratile i različite legislative od kojih je najznačajnija Europska konvencija o krajoliku (Firenca 2000.). Sukladno tome su razvijene metode i procedure valorizacije, zaštite i upravljanja baštinom na temelju krajolika. Cilj ovog projekta je razviti hrvatski model valorizacije, zaštite, upravljanja I korištenja kulturne baštine, a temeljen na krajoliku. Uzor za razvijanje modela je upravo Engleski model valorizacije baštine kroz platformu Povijesne Karakterizacije Krajolika (Historic Landscape Characterisation - HLC). Metodologija za provođenje projekta je metodologija arheologija krajolika. Studija slučaja koja je izabrana za izradu modela je područje današnje Općine Jasenice i Grada Obrovca. Područje studije slučaja predstavlja dovoljno velik prostorni uzorak za primjenu temeljnih principa Povijesne Karakterizacije Krajolika. Ova platforma, jednako kao i procedure će biti dodatno razrađene uzevši u obzir specifičnosti baštine u kršu. Modeli koji će nastati kroz ovaj projekt će biti primjenjivi za ostale krške dijelove Hrvatske, a na metodološkoj razini i na cijelu zemlju. Osim valorizacije i zaštite baštine projekt za cilj ima i razvijanje primijenjene arheologije kao svojevrsne ekstenzije primarne struke, a kroz sinergiju sa društvenim znanostima. Interdisciplinarnost je sadržana u radu na području razvoja kulturnog i baštinskog turizma. Koraci u tom smjeru su izrada zajedničkog kategorijskog aparata, jedinstvene terminologije, akcijskih planova i strategija s ciljem uspostave procedura za upravljanje i korištenje baštine po principu održivosti, a ujedno usmjerene na očuvanje prostora, krajolika i baštine.]]></summary_hr><summary_en><![CDATA[Archaeology has experienced several transformations in the last 20 years. Apart from epistemological and theoretical turns, archaeology was shaped by new technologies and new media enabling new perspectives and areas of practice. One of the greatest transformations which happened in archaeology was the development of landscape archaeology. This turn was followed by various legislation, the most significant being European Landscape Convention (Florence 2000). Accordingly, new methods and procedures were developed including valorisation, protection and heritage management based on landscape.The aim of this project is to developed Croatian model of valorisation, protection, management and use of cultural heritage, based on the landscape. The role model is precisely the English model of heritage valorisation through Historic Landscape Characterisation (HLC) platform. Project methodology is in fact a methodology developed within landscape archaeology. The case study selected to develop the model is an area of Jasenice Municipality and Town of Obrovac. It presents a large enough spatial sample to apply basic HLC principles. This platform as well as the procedures will be additionally developed considering specificities of heritage in karst. Models that will be created through this project will be applicable on other karst areas in Croatia and at the methodological level on the whole country. Apart from valorisation and protection of heritage, the aim of the project is to develop applied archaeology as an extension of the primary discipline, through synergy with social sciences. Interdisciplinarity of the project is reflected in areas such as the development of cultural and heritage tourism. Steps in that direction include conceptualisation of joint categorical apparatus and terminology, action plans and strategies in order to establish procedures for management and use of heritage based on sustainability principles and preservation of space, landscape and heritage.]]></summary_en></project><project>
<id>6836</id><title_hr><![CDATA[Šteta, namjere i odgovornost]]></title_hr><title_en><![CDATA[Harm, Intentions and Responsibility]]></title_en><user_id>22529</user_id><user_firstLast_name>Matej Sušnik</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-4308</code><acronim><![CDATA[HIRe]]></acronim><duration>01.01.2018 - 31.12.2022</duration><status>Završio</status><financ_value>92.945,78 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filozofija, </scie_field_hr><scie_field_en>Philosophy, </scie_field_en><institution_hr><![CDATA[Institut za filozofiju]]></institution_hr><institution_en><![CDATA[Institute for Philosophy in Zagreb]]></institution_en><team_members_id>2690, 4172, 22551, 25046, 861686, 858392, </team_members_id><team_members_names><![CDATA[Tvrtko Jolić, Marko Jurjako, Marin Biondić, Karolina Kudlek, Viktor Ivankovic, Ana Grgić, ]]></team_members_names><keywords_hr><![CDATA[Šteta, namjere, odgovornost, smrt, psihopatija, dopustivost, rat]]></keywords_hr><keywords_en><![CDATA[Harm, intentions, responsibility, death, psychopathy, permissibility, war]]></keywords_en><summary_hr><![CDATA[Šteta, namjera i odgovornost središnji su pojmovi oko kojih se odvijaju suvremene rasprave na području etike, političke filozofije i filozofije djelovanja. Naše istraživanje uklapa se u recentne filozofske rasprave koje tematiziraju značenje tih pojmova kao i njihove normativne implikacije u raznim domenama našega svakodnevnoga života. Istraživanje ćemo podijeliti u tri dijela: (1) Priroda štete; (2) Šteta i moralni značaj namjera; te (3) Individualna i kolektivna odgovornost. U posljednjoj fazi istraživanja objedinit ćemo prethodno ostvarene rezultate s namjerom zadobivanja jedinstvene i koherentne slike o tome na koji su način navedeni pojmovi međusobno povezani.]]></summary_hr><summary_en><![CDATA[Harm, intention, and responsibility are the central concepts around which contemporary discussions on ethics, political philosophy and philosophy of action take place. Our research fits into recent philosophical discussions that discuss the meaning of these concepts as well as their normative implications in the various domains of our everyday life. The research will be divided into three parts: (1) The nature of harm; (2) Harm and the moral significance of intentions; and (3) Individual and collective responsibility. In the last phase of the research, we will combine previously achieved results with the aim of obtaining a unique and coherent image of how these notions are related to each other.]]></summary_en></project><project>
<id>6843</id><title_hr><![CDATA[MOLEKULARNI MEHANIZMI TOKSIČNOSTI PROTUOTROVA I POTENCIJALNIH LIJEKOVA]]></title_hr><title_en><![CDATA[MOLECULAR MECHANISMS UNDERLYING THE TOXICITY OF ANTIDOTES AND POTENTIAL DRUGS]]></title_en><user_id>982</user_id><user_firstLast_name>Maja Katalinić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-7260</code><acronim><![CDATA[CellToxTargets]]></acronim><duration>01.03.2018 - 28.02.2023</duration><status>Završio</status><financ_value>224.739,53 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, Kemija, </scie_field_hr><scie_field_en>Biology, Chemistry, </scie_field_en><institution_hr><![CDATA[Institut za medicinska istraživanja i medicinu rada]]></institution_hr><institution_en><![CDATA[Institute for Medical Research and Occupational Health]]></institution_en><team_members_id>22563, 226, 22504, 657, 19605, 858373, </team_members_id><team_members_names><![CDATA[Sergej Pirkmajer, Ivana Vrhovac Madunić, Antonio Zandona, Nikola Maraković, Josip  Madunić, Ana-Marija Lulić, ]]></team_members_names><keywords_hr><![CDATA[antidoti, organofosforni spojevi, stanice, enzimi, nuspojave]]></keywords_hr><keywords_en><![CDATA[antidotes, organophosphorus compounds, cells, enzymes, side-effects]]></keywords_en><summary_hr><![CDATA[Predloženi projekt predstavlja nov i inovativan pristup u istraživanju protuotrova organofosfornim spojevima (OP), s potencijalom opće primjene u području dizajna novih lijekova. Glavni cilj predloženog projekta je odgovoriti na pitanje kako protuotrovi i potencijalni lijekovi djeluju na staničnoj razini te otkriti mehanizme okidače za neželjene učinke ili nuspojave in vivo. Kako bi se utvrdio mehanizam koji stoji iza takve toksičnosti spojeva i kako bi se potpomognula učinkovitija selekcija kandidata za razvoj lijeka, primijenit će se specifični pretklinički probir temeljen na staničnim testovima. Unutar predloženog projekta ispitat ćemo nekoliko strukturno povezanih setova spojeva. Po dobivanju rezultata istraživanja, moći ćemo primijeniti pristup analize strukture i aktivnosti kako bismo odredili moguće strukturne značajke ispitanih spojeva odgovorne za određene učinke. Tako se značajke poput tih mogu modificirati u ranoj fazi poboljšanja strukture vodećeg spoja bez provođenja ikakvih studija in vivo. To će omogućiti i učinkovitije povratne informacije istraživačima koji rade na oblikovanju npr. protuotrova i doprinijeti razvoju djelotvornije terapije za trovanje OP spojevima. Očekujemo i identifikaciju novih farmakoloških meta na staničnoj razini, kao i mogućnost istraživanja njihovog terapijskog potencijala. Jedna takva meta kod tretmana trovanja OP-ovima, koja je identificirana u našem istraživanju, je novi enzim NRE. Stoga ćemo ispitati ulogu i funkciju ovog enzima i odgovoriti bi li se isti mogao razmatrati kao ciljna molekula u liječenju otrovanja OP-ima ili bi mogao imati indikaciju u liječenju drugih stanja i bolesti. Ovi bi rezultati otvorili i novu perspektivu s utjecajem koji nadilazi prvotno polje primjene. Uz ovaj znanstveni dio, iskusni i kvalificirani istraživački tim nastavit će poticati prijenos tehnologije putem raznih suradnji, kontinuirane nadogradnje i unaprjeđenja metoda te osposobljavanjem u području specifičnih vještina.]]></summary_hr><summary_en><![CDATA[The project presents the new innovative approach in the field of antidote research for poisoning with organophosphates (OP), having the applications in overall drug discovery. The main goal of the project is to answer how the antidotes and drugs act on cell level and uncover the trigger mechanism leading to the side-effects or even severe effects that could occur in vivo. The specific cell-based screening will be applied to define the mechanism behind such unwanted toxicity of compounds and to aid a more efficient selection of a lead candidate for drug development. Within the proposed project, we will test several defined sets of structurally related antidotes/drugs. This will allow us to use, after obtaining sufficient cell-based data, a structure-activity approach to define the possible structural features of tested compounds triggering certain effects. Thus, features like these could be modified in the early lead compound structure refinement process without performing any in vivo studies. More efficient feedback will be given to studies designing drugs and aid the challenging development of an effective treatment primarily for OP poisoning. We also expect to identify new possible targets on the cell level and explore their therapeutic potential. One such target in treating exposure to OPs, NRE, was identified in our earlier research. Therefore, we will study the role and function of this unexplored enzyme and answer whether it could be considered as a potential target in OP treatment or even has an indication for being a target molecule in treatment of other diseases. Our findings should open up a new perspective with potential impact beyond the original scope. Beside the scientific part, the newly established experienced and skilled research team will stimulate a technology transfer through collaborations, continuous upgrading and improvement of methods and training in specific skills.]]></summary_en></project><project>
<id>6846</id><title_hr><![CDATA[Opasnosti i prednosti društvenih mreža: e-profesionalizam zdravstvenih djelatnika]]></title_hr><title_en><![CDATA[Dangers and benefits of social networks: e-professionalism of healthcare professionals ]]></title_en><user_id>22544</user_id><user_firstLast_name>Tea Vukušić Rukavina</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-2140</code><acronim><![CDATA[SMePROF]]></acronim><duration>09.05.2018 - 01.11.2023</duration><status>Završio</status><financ_value>127.364,13 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Javno zdravstvo i zdravstvena zaštita, Dentalna medicina, </scie_field_hr><scie_field_en>Public health and health services, Dental medicine, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>22559, 22557, 22739, 25312, 861501, </team_members_id><team_members_names><![CDATA[Joško Viskić, Danko Relic Relic, Kristijan Sedak, Marko Marelić, Lovela Machala Poplašen, ]]></team_members_names><keywords_hr><![CDATA[e-profesionalizam, zdravstveni djelatnici, društvene mreže, zdravstvena edukacija, studenti, smjernice]]></keywords_hr><keywords_en><![CDATA[e-professionalism, health care professionals, social media, health education, students, guidelines]]></keywords_en><summary_hr><![CDATA[Predloženi projekt ima za cilj istraživanje utjecaja društvenih mreža na e-profesionalizam zdravstvenih djelatnika u Republici Hrvatskoj gdje je e-profesionalizam definiran kao predanost izvršavanju profesionalne zadaća, pridržavanju etičkih principa i osjetljivosti za pacijentovu dobrobit tijekom on-line aktivnosti na društvenim mrežama te na osnovu rezultata razviti i testirati smjernice za poticanje razvoja e-profesionalizma zdravstvenih djelatnika. Rezultati ovog projektnog prijedloga pridonijet će boljem razumijevanju kako se e-profesionalizam razvija tijekom obrazovanja i prakse u zdravstvenoj skrbi. Rezultati istraživanja omogućit će detaljan uvid o korištenju društvenih mreža među zdravstvenim djelatnicima u Republici Hrvatskoj (studentima i nastavnicima medicine i dentalne medicine te doktorima medicine i dentalne medicine) te će se utvrditi razlike ovisno o podgrupi ispitanika čime će se omogućiti usporedba s rezultatima prethodno provedenih međunarodnih istraživanja. Identificiranjem kriterija kojima korisnici društvenih mreža procjenjuju profesionalizam zdravstvenih djelatnika na društvenim mrežama te vjerodostojnost i kvalitetu pruženih informacija omogućit će se razvijanje teorijske postavke modela za kreiranje preporuka o profesionalno adekvatnom ponašanju na društvenim mrežama u skladu su potrebnim vještinama koje omogućuju odgovorno ponašanje i očuvanje kredibiliteta profesije. Rezultati istraživanja će se primijeniti kao temelj za razvoj novih znanstveno utemeljenih edukativnih sadržaja o e-profesionalizmu u kurikulumima MEF-a i SFZG-a te će pridonijeti unaprjeđenju cijelo-životnog učenja zdravstvenih djelatnika. Ovim istraživanjem će se utvrditi determinante koje u pozitivnom i negativnom aspektu utječu na e-profesionalizam zdravstvenih djelatnika, obuhvaćajući sve generacije zdravstvenih djelatnika, te na taj način pridonijeti boljem razumijevanju dinamike kompleksnog odnosa u dinamičnom okruženju društvenih mreža koje se neprestano razvija.]]></summary_hr><summary_en><![CDATA[Aim of the proposed project is to explore the impact of social networks on e-professionalism of healthcare professionals in the Republic of Croatia where e-professionalism is defined as a commitment to carry out a professional task, adhering to ethical principles and sensitivity to patient&#39;s well-being during on-line activities on social networks, and based on these results develop and test guidelines to encourage the development of e-professionalism of the professional staff. The result of the project proposal will contribute to a better understanding of how e-professionalism develops during education and practice in health care. The results of the research will provide a detailed insight into the use of social networks among healthcare professionals in the Republic of Croatia and will determine the differences in attitudes and behaviors depending on the subgroup of respondents, which will enable comparison with the results of previously conducted international research. By identifying the criteria based on which social network users evaluate the professionalism of health professionals on social networks and the credibility and quality of information provided, it will enable the development of the theoretical set of models for the development of recommendations on professionally adequate behavior on social networks in accordance with the necessary skills that enable responsible behavior and the preservation of the credibility of the profession. This research will identify all determinants that affect the e-professionalism of health professionals in a positive and negative aspect, including all generations of healthcare professionals, and thus contribute to a better understanding of the dynamics of this evolving interaction. Results will be used as a basis for the development of new, evidence-based educational content on e-professionalism in School of Medicine and School of Dental Medicine University of Zagreb curricula.]]></summary_en></project><project>
<id>6851</id><title_hr><![CDATA[Utjecaj polimera na radiolitičku sintezu magnetskih nanočestica]]></title_hr><title_en><![CDATA[The impact of polymers on the radiolytic synthesis of magnetic nanoparticles]]></title_en><user_id>350</user_id><user_firstLast_name>Tanja Jurkin</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-7337</code><acronim><![CDATA[POLRADNANOP]]></acronim><duration>01.03.2018 - 31.08.2023</duration><status>Završio</status><financ_value>214.962,03 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>616, 25099, </team_members_id><team_members_names><![CDATA[Anđela Pustak, Ivan Marić, ]]></team_members_names><keywords_hr><![CDATA[polimeri, gama-zračenje, magnetske nanočestice,  Au, prevlaka, SERS]]></keywords_hr><keywords_en><![CDATA[polymers, gamma-irradiation, magnetic nanoparticles, gold layer, SERS]]></keywords_en><summary_hr><![CDATA[U ovom uspostavnom istraživačkom projektu istraživat će se utjecaj raznih polimera na gama-radiolitičku sintezu superparamagnetskih nanočestica željezovog oksida (SPION). SPION-i su odabrani kao modelni sustav radiolitički sintetiziranih nanočestica. SPION-i se mogu koristiti u raznim primjenama poput nosača za isporuku lijeka, kontrastnih sredstava, liječenja hipertermijom, razlaganja vode i kod magnetskog razdvajanja proteina. Radiolitička sinteza nanočestica (NČ) je novo područje istraživanja u Hrvatskoj koje do sada nikada nije bilo financirano. Treba istaknuti da predlagateljica projekta ima znanstvenu i eksperimentalnu podlogu u tom području. U ovom projektu sustavno će se istraživati utjecaj gama-zračenja kao i utjecaj odabranih polimera (poput PVP-a, dekstrana i PEO-a) na koloidnu stabilnost radiolitički sintetiziranih SPION-a, njihovu veličinu, oblik i fazni sastav. Pored toga, redukcijska svojstva ispitivanih polimera mjerit će se kvantitativnim određivanjem koncentracije nastalih Fe2+ iona u ozračenim suspenzijama. Konkretno, koncentracija Fe2+ iona bit će određena spektrofotometrijskom tehnikom upotrebom 1,10-fenantrolina i/ili redoks titracijom pomoću otopine kalijevog permanganata. U ovom projektu naći će se optimalni eksperimentalni uvjeti (najpogodniji polimer, doza i brzina doze gama-zračenja) za radiolitičku sintezu stabilne suspenzije nanočestica magnetita, odnosno SPION-a. Da bi se dobio nanomaterijal aktivan za površinski pojačanu Ramanovu spektroskopiju (SERS), površina SPION-a obložit će se zlatom (SPION@Au). Kakvoća i homogenost zlatne prevlake bitno ovisi o postupku oblaganja. U ovom projektu zlato će se nanijeti na SPION-e radiolitičkom tehnikom. Kakvoća zlatnih prevlaka ispitat će se UV-Vis spektroskopijom i visoko rezolucijskom elektronskom mikroskopijom. Uporaba SPION@Au NČ za određivanje mikromolarnih koncentracija organskih boja prisutnih u vodenoj otopini istraživat će se površinski pojačanom Ramanovom spektroskopijom.]]></summary_hr><summary_en><![CDATA[In this installation research project the impact of various polymers on the gamma radiolytic synthesis of superparamagnetic iron oxide nanoparticles (SPIONs) will be studied. The SPIONs are selected as model radiolytically synthesized nanoparticles (NPs). SPIONs can be used in various applications such as drug delivery, contrast agents, hyperthermia treatments, water splitting, magnetic separation, etc. The radiolytic synthesis of nanoparticles is new area of investigation in Croatia that has never been financially supported by Croatian authorities. It should be pointed out that project applicant has scientific and experimental background in the field. In this project we will systematically study the influence of irradiation conditions and the impact of certain polymers, such as PVP, dextran, PEO, etc., on colloidal stability of radiolitically synthesized SPIONs, their size and shape and phase composition. In addition, the reducing ability of investigated polymers will be quantitatively determined by measuring ferrous (Fe2+) ions concentration formed in irradiated suspensions. The spectrophotometric technique using 1,10-Phenanthroline or redox titration using potassium permanganate solution will be used for Fe2+ determination. The optimal experimental conditions (the most suitable polymer, irradiation dose and dose rate) for radiolytically synthesized magnetite suspension, i.e. SPIONs will be found. In order to obtain Surface Enhanced Raman Spectroscopy (SERS) active material, the surface of SPIONs will be coated with gold (SPIONs@Au core-shell NPs). The quality and homogeneity of gold coating depends significantly on the coating procedure. In this project gold will be coated onto SPIONs using radiolytic technique. The gold coatings will be examined using UV-Vis spectroscopy and high resolution electron microscopy. The capacity of SPIONs@Au NPs for determination of micromolar concentrations of organic dye dissolved in aqueous solution will be tested using SERS.]]></summary_en></project><project>
<id>6858</id><title_hr><![CDATA[Učinkovita stvarnovremenska obrada brzih geoprostornih podataka]]></title_hr><title_en><![CDATA[Efficient Real-Time Processing of Fast Geospatial Data]]></title_en><user_id>2706</user_id><user_firstLast_name>Krešimir Pripužić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-9066</code><acronim><![CDATA[RETROFIT ]]></acronim><duration>01.03.2018 - 28.02.2023</duration><status>Završio</status><financ_value>167.720,92 eur</financ_value><scie_area_hr>Tehničke znanosti, Prirodne znanosti, </scie_area_hr><scie_area_en>Technological sciences, Natural sciences, </scie_area_en><scie_field_hr>Računarstvo, Geografija, </scie_field_hr><scie_field_en>Computer sciences, Geography, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>6720, 17866, 3137, 22607, 22730, 22460, 5345, 858427, </team_members_id><team_members_names><![CDATA[Aleksandar Antonić, Martina Marjanović, Mladen Maradin, Ivan Livaja, Mirjana Pripužić, Siniša Sovilj, Damjan Katušić, Josip Marić Marić, ]]></team_members_names><keywords_hr><![CDATA[raspodijeljena obrada podataka, obrada velikih podataka, internet stvari, stvarnovremenska obrada podataka, primijenjeno strojno učenje]]></keywords_hr><keywords_en><![CDATA[distributed data processing, big data processing, internet of things, real-time data processing, applied machine learning]]></keywords_en><summary_hr><![CDATA[Svjedoci smo dramatične tranzicije našeg suvremenog informacijski usmjerenog svijeta kojom iz razdoblja samo jednog uređaja povezanog na Internet po osobi prelazimo u razdoblje Interneta stvari u kojem po osobi postoji mnoštvo povezanih uređaja. Mnogi od ovih uređaja generiraju specifičnu vrstu strujećih podataka koji su najčešće velike frekvencije, ali uglavnom male veličine, te se nazivaju se Brzi podaci. Projekt RETROFIT (Učinkovita stvarnovremenska obrada brzih geoprostornih podataka) rješavat će otvorena pitanja vezana uz filtriranje i obradu brzih podataka u stvarnom vremenu. Pritom će se uglavnom usredotočiti na brze geoprostorne podatke, kao posebnu vrstu brzih podataka koji uključuju geoprostorne informacije (npr. geografsku širinu i dužinu). Kroz svoje ciljeve istraživanja, projekt RETROFIT će istražiti učinkovitu usporedbu pristiglih brzih geoprostornih podataka s unaprijed definiranim interesima za njima te primjenu tehnika strojnog učenja u stvarnom vremenu nad njima kako bi ponudio rješenje za stvarnovremensku obradu brzih geoprostornih podataka. Kako bi se učinkovito nosio s problemom velike frekvencije takvih podataka, projekt RETROFIT će se usredotočiti na raspodijeljenu obradu podataka u računalnom grozdu. Identificirat će se nekoliko studijskih slučajeva u kojima je nužna stvarnovremenska obrada brzih geoprostornih podataka, kao što je npr. sustav ranog upozoravanja na poplave koji obrađuje podatke o vodostajima, protjecajima i padalinama u stvarnom vremenu. Ciljevi projekta će se postići sustavnim pristupom istraživanju i ostvarivim planom rada. Osim toga, uspostavit će se multidisciplinarna istraživačka skupina i postavit će se eksperimentalni računalni grozd u laboratoriju. Razvijeno rješenje, kao i stečeno znanje, poslužit će kao osnova za prijavu na druge izvore financiranja u završne dvije godine projekta, što će omogućiti održivost projekta RETROFIT.]]></summary_hr><summary_en><![CDATA[We are witnessing a dramatic transition in our modern information-oriented world from the age of a single Internet-connected device per person into the age of the Internet of Things (IoT) where there is a multitude of connected devices per person. Many of these devices generate a specific type of streaming data which is usually highly frequent, but mostly small in size, and is called the Fast data. The project RETROFIT (Efficient Real-Time Processing of Fast Geospatial Data) will address open questions regarding the real-time filtering and processing of the Fast data. In doing so, it will mostly focus on the fast geospatial data, as a special type of Fast data which includes geospatial information (e.g. latitude, longitude). Through its research objectives, the RETROFIT project will investigate efficient matching of generated fast geospatial data with predefined interests in such data and usage of machine learning techniques in real-time on such data to provide a solution for real-time processing of the fast geospatial data. To efficiently deal with the problem of a high frequency of such data, the RETROFIT project will focus on distributed data processing in the computer cluster. A several case studies, in which real-time processing of fast geospatial data is required, will be identified, such as an early warning system for floods which processes water level, discharge and precipitation data in real-time. The RETROFIT project objectives will be reached through the systematic approach to research and a realistic work plan. Additionally, a multidisciplinary research group will be established and an experimental computer cluster will be set up in the laboratory. The developed solution, as well as gained knowledge, will be used as the basis for applying to other funding sources in the last two project years, which will enable viability of the RETROFIT project.]]></summary_en></project><project>
<id>6859</id><title_hr><![CDATA[Diamantoidni sustavi s heteroatomima – priprava i primjena u razvoju naprednih materijala]]></title_hr><title_en><![CDATA[Diamondoid scaffolds containing heteroatoms – preparation and application in development of advanced materials]]></title_en><user_id>2988</user_id><user_firstLast_name>Marina Šekutor</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-9653</code><acronim><![CDATA[DiamMat]]></acronim><duration>01.09.2018 - 31.08.2023</duration><status>Završio</status><financ_value>162.585,44 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>3215, 3336, 28147, </team_members_id><team_members_names><![CDATA[Marija Alešković, Margareta  Sohora, Nataša  Burić, ]]></team_members_names><keywords_hr><![CDATA[diamantoidi, napredni materijali, organska sinteza, kavezasti spojevi, policiklički ugljikovodici, polifunkcionalizacija, alkilni derivati]]></keywords_hr><keywords_en><![CDATA[diamondoids, advanced materials, organic synthesis, cage compounds, polycyclic hydrocarbons, polyfunctionalization, alkyl derivatives]]></keywords_en><summary_hr><![CDATA[Razvoj novih materijala je tema od iznimne važnosti u kemiji te su najnovija istraživanja posvećena otkriću, poboljšanju i primjeni materijala u tehnologijama budućnosti. Naročito su intenzivne studije materijala baziranih na ugljiku, pri čemu je dijamant jedan od primjera. Međutim primjena dijamanta, unatoč njegovim mnogobrojnim izvrsnim svojstvima, ostaje ograničena zbog problema u kontroli selektivnosti njegove funkcionalizacije te nedovoljne uniformnosti strukture. Pogodna alternativa dijamantu su diamantoidi, organski kavezasti spojevi koji posjeduju sličnu strukturu, no koji se mogu selektivno supstituirati. Diamantoidi su stoga na granici između fleksibilnih organskih molekula i anorganskog dijamanta.Kemija diamantoida se značajno razvila u protekla dva desetljeća, no još uvijek ima prilika za daljnji napredak. Naš cilj je pripraviti i okarakterizirati dosad neistražene diamantoidne derivate te ih primijeniti u dizajnu materijala. Ciljne molekule bit će diamantoidni sustavi s heteroatomima uvedenim izravno na kavezastu podjedinicu, a pripravit će se i derivati s poveznicama („spacer“). Planirani spojevi uključuju diamantoidne etere, tioetere, amine (sekundarni i viši), estere, itd. Kako bi se postigli zadani ciljevi, bit će razvijene nove strategije za selektivnu funkcionalizaciju i polifunkcionalizaciju ovakvih spojeva jer precizna supstitucija diamantoida omogućava kontrolu njihovih svojstava. Daljnji korak bit će dizajn svojstava uvođenjem sekundarnih funkcionalnih skupina, a sa ciljem buduće primjene ovakvih spojeva u premazima te kao površinski slojevi na metalima ili poluvodičima. Eksperimentalna istraživanja bit će nadopunjena računalnim metodama kako bi se dobio uvid u fizikalno-kemijska svojstva pojedinih molekula, ali i novonastalih materijala. Predložena temeljna istraživanja će stoga produbiti spoznaje o utjecaju strukture na svojstva naprednih materijala te omogućiti dizajn novih „lead“ spojeva temeljenih na ugljikovim organskim sustavima.]]></summary_hr><summary_en><![CDATA[Development of new materials is an important key topic in chemistry and cutting edge research is devoted to discover, improve and apply them in future technologies. Currently special focus is placed on carbon-based materials, with diamond being a highly attractive scaffold. Despite its numerous excellent properties, diamond is still difficult to control in terms of selective functionalization and material uniformity. An alternative to bulk diamond are diamondoids, organic cage compounds that have a diamond-like structure but can be selectively substituted, thereby bridging the gap between flexible organic molecules and bulk diamond.Chemistry of diamondoids saw a breakthrough in the last two decades but there are still opportunities for further development. Our goal is to prepare and characterize unexplored diamondoid derivatives and apply them in materials design. Target compounds will be diamondoid scaffolds selectively functionalized with heteroatoms bound on the cage itself as well as derivatives with spacers, including ethers, thioethers, amines (secondary and higher), esters, etc. To achieve this, we will go beyond the state-of-the-art and develop new strategies for their selective functionalization and polyfunctionalization, since precise diamondoid substitution enables properties control. The next step will be tailoring of properties by introduction of secondary motifs/functionalities on the prepared diamondoid scaffolds, with a goal to pave the way for future application in coatings and advanced surfaces. Experimental studies will be complemented by computational methods to gain more insight into the physico-chemical nature of both the molecules and the materials they will form. The proposed research will therefore deepen the fundamental knowledge of structure-properties relationship in the design of new candidates for advanced materials, with a focus on highly promising carbon-based organic scaffolds.]]></summary_en></project><project>
<id>6861</id><title_hr><![CDATA[Razvoj postupaka kosimulacija programskih alata za primjenu mekog računarstva u elektroenergetici]]></title_hr><title_en><![CDATA[Co-simulation procedures development for soft computing application in power engineering]]></title_en><user_id>2962</user_id><user_firstLast_name>Marinko Barukčić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-8572</code><acronim><![CDATA[COPESOC]]></acronim><duration>25.05.2018 - 24.11.2023</duration><status>Završio</status><financ_value>211.913,29 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera Osijek, Fakultet elektrotehnike, računarstva i informacijskih tehnologija Osijek]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Electrical Engineering, Computer Science and Information Technology Osijek]]></institution_en><team_members_id>22642, 3110, 25170, </team_members_id><team_members_names><![CDATA[Tin Benšić, Vedrana Jerković Štil, Toni Varga, ]]></team_members_names><keywords_hr><![CDATA[elektroenergetika, distributivne mreže, industrijske mreže, kosimulacija, metode mekog računarstva]]></keywords_hr><keywords_en><![CDATA[electrical power, distribution network, industrial network, co-simulation, soft computing methods]]></keywords_en><summary_hr><![CDATA[U novije vrijeme u području električnih mreža i elektromotornih pogona aktualna je problematika vezana uz obnovljive izvore, energetski samoodržive mreže (mikro mreže), napredne (pametne, inteligentne sustave) i poboljšanje energetske učinkovitosti. Pri rješavanju ovih problema potrebno je provesti brojne simulacije za planiranje i upravljanje sustava. Prilikom toga nužno je što realističnije modelirati fizikalne pojave i razviti procedure koje će u kraćem vremenu dati preciznije rezultate. Realistično modeliranje uzrokuje visoku složenosti matematičkih modela što ograničava primjenu klasičnih metoda. Prilagodba metoda mekog računarstva rješavanju problema u elektroenergetici otvara mogućnost povećavanja kvalitete simulacija uz smanjenje vremena proračuna. Primjena ovih metoda se brzo razvija usljed brzog razvoja računalnih znanosti (računalnih sklopova i programa). Recentna literatura ukazuje na robusnost u primjenjivosti navedenih metoda. Svrha projektnog prijedloga je razvojem procedura za sinergiju tj. kosimulaciju algoritama mekog računarstva i proračuna fizikalnih veličina sustava dati okvir za rješavanje složenih postojećih i budućih probleme u elektroenergetici. Prema pregledu literature navedeni pristup je tek u začetku primjene u promatranom području. Projektnim prijedlogom predlaže se istraživanje mogućnosti kosimulacije računalnih programa specijaliziranih posebno za simulacije distributivnih mreža i elektromotornih pogona i programa posebno specijaliziranih za metode mekog računarstva. Razvijene kosimulacijske procedure potrebno je uspješno primijeniti za rješavanje specifičnih problema u području distributivnih i industrijskih mreža opisanih u ciljevima projektnog prijedloga. Svrha znanstveno-istraživačkog projekta opisanog projektnim prijedlogom je osposobljavanje istraživačke grupe za primjenu robusnih metoda mekog računarstva u elektroenergetici.]]></summary_hr><summary_en><![CDATA[The most recent topics form the electrical grid and drives research field are focused on problems regarding renewable power sources, self-sustained power grids (micro grids), advanced (smart, intelligent) systems and energy efficiency improvement. To solve the problems that occur in practice and research many planning and system management simulation’s need to be completed. Accurate physical models and less time-consuming procedures are needed to further evolve the electrical system. In contrary, accurate modelling leads to high mathematical complexity of the model that limits the usability of the classical approach to solving problems. Adapting soft computing methods to problems in power engineering opens the possibility to increase the quality of the simulations while reducing time consumption. The application of these methods is developing fast with the rapid evolution of computer science, software and hardware. Recent literature reports high robustness of soft computing in practice.The proposed project main objective is development of synergy (co-simulation) algorithms for soft computing and system physical quantities calculation giving the framework for solving complex existing and future problems in power engineering.According to the literature, the mentioned approach to solving problems is still unexplored. Project proposal suggests research of the co-simulation possibilities of the specialized soft computing software with the electrical grid and drives simulation software. The developed co-simulation procedures need to be successfully implemented for solving specific problems in the field of distributive and industrial grids described in the project proposal.The scientific research project goal is to form a qualified research group for application of soft computing methods in power engineering.]]></summary_en></project><project>
<id>6865</id><title_hr><![CDATA[Emulacija analognih sustava u stvarnom vremenu]]></title_hr><title_en><![CDATA[Towards cost-effective real-time emulation of analog systems]]></title_en><user_id>13699</user_id><user_firstLast_name>Vladimir Čeperić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-1900</code><acronim><![CDATA[EMUAN]]></acronim><duration>01.06.2018 - 31.05.2023</duration><status>Prekinut</status><financ_value>214.230,19 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>26443, </team_members_id><team_members_names><![CDATA[Alma Traživuk, ]]></team_members_names><keywords_hr><![CDATA[Emulacija, simulacija, modeliranje, hardverska simulacijska petlja, FPGA]]></keywords_hr><keywords_en><![CDATA[Emulation, simulation, modeling, hardware-in-the-loop, FPGA]]></keywords_en><summary_hr><![CDATA[Glavni cilj projekta je razviti novi tip emulacije analognih nelinearnih sustava u stvarnom vremenu uvođenjem distribuiranog načina simulacije po događaju.Predloženi pristup omogućit će potpunu virtualizaciju analognog hardvera. Hardver koji treba opisati, modelirati i emulirati na brz način zamjenjuje se modelom koji se izvodi u realnom vremenu na cjenovno povoljnim FPGA ili mikrokontrolerskim platforama.Postoje brojne primjene predloženog rješenja npr. u automobilskoj industriji, industriji infrastrukturne opreme, radara, robotici, energetskih sustava, udaljenih sustava poput platformi, industriji poluvodiča i integriranih sklopova, javnim komunalnim uslugama i mnogim drugim.]]></summary_hr><summary_en><![CDATA[The main objective of this project is to revolutionize the hardware emulation by introducing a decentralized, event-driven way of simulating analog non-linear systems in the digital domain in real time on commodity hardware.The proposed approach will enable full virtual prototyping of analog non-linear hardware. Such hardware is replaced by the model which runs in real-time on a cost-effective FPGA platform or a micro-controller board.There are numerous applications of the proposed system in the automotive industry, infrastructure equipment industry, radar-related industry, robotics, power systems, off-shore systems, integrated-circuits related, public utility and many other. ]]></summary_en></project><project>
<id>6868</id><title_hr><![CDATA[Glikozilacija serumskog transferina kao faktor u mehanizmu prijenosa željeza]]></title_hr><title_en><![CDATA[Glycosylation as a factor in the iron transport mechanism of human serum transferrin]]></title_en><user_id>4009</user_id><user_firstLast_name>Tin Weitner</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-9537</code><acronim><![CDATA[GlyMech]]></acronim><duration>01.02.2018 - 31.01.2023</duration><status>Prekinut</status><financ_value>284.955,87 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, Biologija, </scie_field_hr><scie_field_en>Chemistry, Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Farmaceutsko-biokemijski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Pharmacy and Biochemistry]]></institution_en><team_members_id>5548, 25197, 26503, </team_members_id><team_members_names><![CDATA[Ivan Biruš, Tomislav Friganović, Valentina Borko, ]]></team_members_names><keywords_hr><![CDATA[željezo, transferin, glikozilacija, ravnoteža, kinetika, mehanizam]]></keywords_hr><keywords_en><![CDATA[iron, transferrin, glycosylation, equilibrium, kinetics, mechanism]]></keywords_en><summary_hr><![CDATA[Projekt obuhvaća temeljno istraživanje utjecaja glikozilacije transferina, glavnog prenositelja željeza u ljudskom organizmu, na ravnotežu i kinetiku vezivanja željeza. Znanstveni ciljevi ovog projekta su: 1. određivanje konstanata ravnoteže vezivanja željeza za različite glikoforme transferina, 2. određivanje redukcijskog potencijala željeza vezanog u različitim glikoformama transferina te 3. određivanje kinetike i mehanizma vezanja i otpuštanja željeza iz različitih glikoformi transferina.Većina transferina su topljivi glikoproteini koji se sastoje od jednog lanca sa 700 aminokiselinskih ostataka i glikanskog dijela heretogene strukture i različitog sadržaja sijalinske kiseline. Tijekom fizioloških ili patofizioloških promjena u organizmu dolazi do post-translacijskih promjena u glikozilaciji transferina, pri čemu udio nesijaliniziranog transferina postaje značajno povišen. Promjene u razmjerno velikom glikanskom dijelu transferina mogu imati značajan utjecaj na konstantu vezivanja željeza te na vezivanje za transferinski receptor ciljnih stanica. Mehanizam vezivanja i otpuštanja željeza povezan je s njegovim redukcijskim potencijalom koji ovisi o različitim faktorima (npr. pH, sinergijski anion, itd.), a promjenom glikozilacije transferina također može doći i do značajne promjene redukcijskog potencijala te promjena u kinetici vezivanja ili otpuštanja željeza.Projekt osigurava preduvjete za znanstvenu izvrsnost i razvoj samostalnih istraživačkih karijera mladih znanstvenika poboljšanjem uvjeta rada u smislu opreme i drugih resursa te uklanjanja prepreka njihovoj mobilnosti. Provedbom projekta također će ojačati njihov kapacitet za povlačenje financijskih sredstava iz fondova EU i ostalih financijskih izvora te omogućiti održivost i proširenje znanstvene djelatnosti uspostavljene grupe.]]></summary_hr><summary_en><![CDATA[The proposed fundamental research of transferrin, the principal iron-transporting protein in the human body, and the impact of its glycosylation pattern on the equilibrium and kinetics of iron binding has the following scientific objectives: 1. determination of the iron-binding equilibrium constants for transferrin glycoforms, 2. determination of the reduction potential of iron bound to transferrin glycoforms, and 3. determination of the kinetics and mechanism of iron binding and release from transferrin glycoforms.Most transferrins are soluble glycoproteins consisting of a single chain of 700 amino acid residues and heterogeneous glycan structures. Physiological or pathophysiological changes in the organism lead to post-translational changes in the glycosylation of transferrin, resulting in the significantly increased levels of desialylated transferrin. Changes in relatively large glycan structures of transferrin may have a significant effect on the iron-binding constant and may also affect binding to the target cell receptors. The iron binding and release mechanism is associated with its reduction potential that depends on various factors (e.g. pH, synergic anion, etc.). Any alteration of the transferrin glycosylation pattern can result in changes in the reduction potential as well as the kinetics of iron binding or release.This project will facilitate scientific excellence and development of independent research careers of young scientists by increasing employment and improving their working conditions in terms of equipment and other resources or by removing obstacles to their mobility. Implementation of the project will also strengthen the capacity of young scientists to withdraw financial resources from EU funds and other sources and thus ensure the sustainability and expansion of the established research group’s scientific activity.]]></summary_en></project><project>
<id>6869</id><title_hr><![CDATA[Grupa za primijenjenu ultrabrzu spektroskopiju i fotokemijsku identifikaciju]]></title_hr><title_en><![CDATA[Group for Applied ultrafast Spectroscopy and Photochemical Identification]]></title_en><user_id>2622</user_id><user_firstLast_name>Silvije Vdović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-5831</code><acronim><![CDATA[GASPI]]></acronim><duration>01.03.2018 - 31.08.2023</duration><status>Završio</status><financ_value>178.591,81 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, Kemija, </scie_field_hr><scie_field_en>Physics, Chemistry, </scie_field_en><institution_hr><![CDATA[Institut za fiziku]]></institution_hr><institution_en><![CDATA[Institute of Physics in Zagreb]]></institution_en><team_members_id>4129, 12365, 22526, 25339, 865210, </team_members_id><team_members_names><![CDATA[Mario Rakić, Damir Dominko, Antonija Husak, Mateo Forjan, Vedran Brusar, ]]></team_members_names><keywords_hr><![CDATA[ultrabrza spektroskopija, fotofizika, fotokemija, tjerani fenomeni, nelinearna optika]]></keywords_hr><keywords_en><![CDATA[ultrafast spectroscopy, photophysics, photochemistry, driven phenomena, nonlinear optics]]></keywords_en><summary_hr><![CDATA[Cilj ovog projekta je uspostava nove istraživačke grupe koja će se fokusirati na proučavanje fotokemijskih procesa korištenjem metoda ultrabrze spektroskopije. Tranzijentna apsorpcija (TA) otkriva dinamiku promatranjem vremenskog razvoja sistema na potencijalnoj plohi pobuđenog stanja. Fotoinducirani procesi kao što su fotodisocijacija, fotoizomerizacija, prijenos energije i slični započinju apsorpcijom zračenja iz pumpne zrake. Pobuđena populacija prelazi na potencijalnu plohu pobuđenog stanja na kojoj se odvijaju fotoinducirani procesi. Probni puls zatim međudjeluje s pobuđenom molekulom te biva apsorbiran uzrokujući apsorpcijski spektar. Transfer populacije kroz međustanja može se pratiti uzimanjem TA spektara za niz vremenskih pomaka unutar vremenskog prozora od interesa. Kako bi se izvuklo što više korisnih informacija o tijeku fotoinduciranog procesa potrebna je pažljiva analiza TA spektara, što je često vrlo zahtijevan posao. Za otkrivanje procesa odgovornih za opažene spektralne promjene obično se koristi globalna analiza bazirana na određenom modelu. Rezultat prilagodbe su kinetički profili i pridruženi spektri zajedno sa konstantama rata. Ovim projektom unaprijeđeni eksperimentalni postav zasnovan na postojećem laserskom sustavu omogućiti će visoku vremensku rezoluciju te detekciju vrlo malih promjena tranzijentnih spektara. Eksperimentalni postav za tranzijentnu apsorpciju primijenti će se na istraživanje mehanizma fotokemijske reakcije nastajanja kinon-metida (QM) iz derivata fenola, naftola i antrola u fotokemijskoj reakciji dehidratacije. Važnost ovog istraživanja temelji se na činjenici da QM alkiliraju i križno spajaju lance DNA na temelju čega se zasniva antiproliferativno djelovanje nekih antitumorskih antibiotika. Također, dio projekta vezan je uz istraživanja tjeranih nelinearnih fenomena u sustavima s izraženim elektron-fonon vezanjem tehnikama ultrabrze spektroskopije koje su bazirane na detekciji signala pomoću Fourier transformacija.]]></summary_hr><summary_en><![CDATA[The aim of this project is to establish a new research group that will focus on investigation of photochemical processes using ultrafast spectroscopy methods. Monitoring of the ultrafast dynamics in complex molecular systems relies on pump – probe measurements with ultrashort pulses. Photo-induced processes like photodissociation, photoisomerisation, energy transfer and similar start with absorption of radiation from the pump beam. The population is then transferred to the upper potential energy surface where photo-induced process takes place. Probe pulse, following the pump pulse at some time delay, is absorbed by the molecule to form an absorption spectrum. The population transfer through intermediate states is then traced by taking the transient absorption (TA) spectrum at time delays within the time interval of interest. In order to extract as much information as possible, a careful analysis of TA spectra is needed, which can be quite tedious. To unravel processes underlying the observable spectroscopic changes, model-based global analysis is usually employed. As a result, kinetic profiles and associated spectra for the resolved components are obtained, together with rate constants. In this project, upgrade of a experimental equipment will enable high temporal resolution and detection of very small changes in transient spectra. The transient absorption setup will be used for investigation of mechanism of quinon methide (QM) generation from the phenol, naphthol and anthrol derivatives in photochemical reaction of dehydration. The importance of this research lies in the fact that QM alkylate and cross-link DNA chains which is the basis for antiproliferative activity of some antitumor antibiotics. In addition, one separate segment of the project is related to investigation of driven, nonlinear phenomena in systems with strong electron-phonon coupling using ultrafast Fourier transform spectroscopy techniques. ]]></summary_en></project><project>
<id>6880</id><title_hr><![CDATA[Rotavirusi u ekosustavu Republike Hrvatske: molekularna epidemiologija i zoonotski potencijal]]></title_hr><title_en><![CDATA[Rotaviruses in Croatian Ecosystem: molecular epidemiology and zoonotic potential]]></title_en><user_id>2597</user_id><user_firstLast_name>Dragan Brnić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-8580</code><acronim><![CDATA[REco]]></acronim><duration>01.04.2018 - 31.03.2023</duration><status>Završio</status><financ_value>319.122,66 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo, Prirodne znanosti, </scie_area_hr><scie_area_en>Biomedicine and health sciences, Natural sciences, </scie_area_en><scie_field_hr>Veterinarska medicina, Biologija, Javno zdravstvo i zdravstvena zaštita, </scie_field_hr><scie_field_en>Veterinary medicine, Biology, Public health and health services, </scie_field_en><institution_hr><![CDATA[Hrvatski veterinarski institut]]></institution_hr><institution_en><![CDATA[Croatian Veterinary Institute]]></institution_en><team_members_id>22596, 2543, 25601, 862758, 865085, </team_members_id><team_members_names><![CDATA[Ines Škoko, Nina Krešić, Željko Pavlinec, Rok Kogoj, Valentina Kunić, ]]></team_members_names><keywords_hr><![CDATA[Rotavirus, ekosustav, Republika Hrvatska, NGS, virusna metagenomika, cijeli genom, genotip ]]></keywords_hr><keywords_en><![CDATA[Rotavirus, Ecosystem, Croatia, NGS, viral metagenomics, whole genome, genotype]]></keywords_en><summary_hr><![CDATA[Rotavirusi, a posebno vrsta Rotavirus A (RVA), su široko rasprostranjeni uzročnici crijevnih infekcija visoke prevalencije i patogenosti u ljudi i različitih vrsti životinja. Dokazi učestalog križanja evolucije humanih i životinjskih  rotavirusa su do sada puno puta opisani. Međutim istraživanja životinjskih RVA sojeva znatno zaostaju za humanim, a naročito istraživanja sojeva podrijetlom od divljih životinja. Stoga je glavni cilj ovog projekta provesti sinkroniziranu prostorno-vremensku molekularnu epidemiološku studiju kako bi se procijenio zoonotski potencijal autohtonih rotavirusa A u ekosustavu Republike Hrvatske, slijedeći pri tome pristup „Jedno zdravlje? (One Health). Naša multidisciplinarna ideja istraživanja donosi cjelovitost i sveobuhvatnost, a takav usklađeni pristup veterinarske i humane medicine se smatra nužnim. Odabrana metodologija će nam pružiti jedinstvenu prigodu bolje upoznati genomsku strukturu, genotipski sastav genoma, filogenetsku srodnost i zoonotski potencijal hrvatskih autohtonih sojeva RVA istovremeno utvrđenih u domaćih i divljih životinja, u ljudi te okolišu. Povrh toga, NGS tehnologija primijenjena u postupku sekvenciranja cijelog genoma RVA će pri tome razotkriti raznolikost virusnog metagenoma u ekosustavu Republike Hrvatske, ali i moguće nove virusne prijetnje od javno-zdravstvenog značaja. Ovo istraživanje će po prvi puta definirati strukturu cijelog genoma RVA podrijetlom od nekoliko vrsti divljih životinja te donijeti novi pogled na njihovu evoluciju i sposobnost za pojavljivanje u populacijama ljudi i domaćih životinja. Novoosnovana autohtona RVA virusna banka će  zajedno s genotipskim bazama podataka omogućiti ubrzano genetsko praćenje novih emergentnih zoonotskih RVA sojeva. Ovim projektnim prijedlogom ćemo osnovati REco istraživačku skupinu s ciljem jačanja znanja, umrežavanja i konkurentnosti svakog člana u Europskom istraživačkom prostoru što će u konačnici rezultirati novim suradničkim istraživačkim inicijativama.]]></summary_hr><summary_en><![CDATA[Rotaviruses, especially the species Rotavirus A (RVA), are worldwide distributed enteric pathogens with high prevalence and pathogenicity in humans and variety of animals. The evidence for frequent intersections between the evolution of human and animal RVAs has been well documented. However the research on animal RVA strains is significantly lagging, especially on strains originating in wildlife. Therefore, the main aim of this project is to conduct a synchronized spatiotemporal molecular epidemiology study in order to assess the zoonotic potential of autochthonous RVA in Croatian ecosystem, by following the One Health concept. Our multidisciplinary research idea brings integrity and comprehensiveness in its approach and such concerted effort at the interface of veterinary medicine and public health is considered as warranted. By means of selected methodology, we will have a unique opportunity to get a closer look into genomic structure, genotype constellation, phylogenetic relatedness and zoonotic potential of Croatian autochthonous RVA strains simultaneously detected in domestic and wild animals, humans and environment. Moreover, the NGS technology applied for RVA whole genome sequencing will additionally reveal the diversity of viral metagenomes present in Croatian ecosystem and potentially expose new viral threats of public health importance. This study will be the first one defining a genetic backbone of RVAs in several wildlife species and bring a novel perspective on RVA evolution and the capacity of wildlife RVAs for the emergence into human and domestic animal populations. An autochthonous RVA virus bank will be formed, along with genotype databases enabling future seamless genetic tracking of novel emerging zoonotic strains. This project proposal will install a REco research group with the aim to boost knowledge, networking and competitiveness of each team member in the European Research Area, resulting in future novel collaborative research initiatives.]]></summary_en></project><project>
<id>6881</id><title_hr><![CDATA[Zeleni modularni putnički brod za Mediteran]]></title_hr><title_en><![CDATA[Green Modular Passenger Vessel for Mediterranean]]></title_en><user_id>252</user_id><user_firstLast_name>Nikola Vladimir</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-1253</code><acronim><![CDATA[ZEMP / GRiMM]]></acronim><duration>01.03.2018 - 31.07.2023</duration><status>Završio</status><financ_value>144.667,86 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Brodogradnja, Strojarstvo, </scie_field_hr><scie_field_en>Naval architecture, Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>22527, 22651, 22745, 19119, 25261, 858374, </team_members_id><team_members_names><![CDATA[Ivica Ančić, Inno Gatin, Marina Tošić, Vuko Vukcevic, Maja Perčić, Ivana Jovanović, ]]></team_members_names><keywords_hr><![CDATA[putnički brod, modularni pristup, hidrodinamičke značajke, energetska učinkovitost, buka, vibracije ekološka prihvatljivost]]></keywords_hr><keywords_en><![CDATA[passenger vessel, modular approach, hydrodynamic characteristics, energy efficiency, noise, vibrations, environmental impact]]></keywords_en><summary_hr><![CDATA[Svrha projekta „Zeleni modularni putnički brod za Mediteran – ZEMP“ je razvoj nove metodologije projektiranja malih putničkih brodova namijenjenih za plovidbu Mediteranskim morem primjenom modularnog pristupa. Modularni pristup omogućava promjenu proizvodne paradigme od klasičnog pristupa u kojemu se sve komponente izrađuju u brodogradilištu prema paralelnoj proizvodnji različitih modula od strane kooperanata te završnoj montaži u brodogradilištima. Predviđeno je da se putnički broj sastoji od tri modula koji će činiti trup broda, brodski energetski sustav i nadgrađe. Kombinacijom tih modula mijenjat će se karakteristike broda, kao što su dimenzije, kapacitet, propulzijske značajke, pogonsko gorivo i razne inovativne energetski učinkovite tehnologije. Dakako, ovakav pristup povećava složenost procesa projektiranja jer je već u fazi projektiranja modula potrebno uzeti u obzir mnoštvo različitih značajki kojima koncepti trebaju udovoljavati, kao i pripadajući regulatorni okvir.U sklopu projekta najprije će biti provedena analiza tržišta za razna područja plovidbe unutar Mediterana kako bi se mogle odrediti potrebe kojima putnički brodovi trebaju udovoljiti. Na temelju toga će biti predloženo nekoliko preliminarnih koncepata, dok će finalni koncepti biti razvijeni uzimajući u obzir i sve druge aspekte projektiranja: hidrodinamičke i propulzijske značajke, jednostavnost procesa izrade, razinu ugode za putnike i posadu, kao i ekološki prihvatljiva rješenja energetskog sustava. Na temelju kriterija za pojedine namjene odabrat će se optimalni koncepti malog putničkog broda. Projekt će rezultirati predloženim konceptima koji će, ovisno o potrebama tržišta, imati niže troškove proizvodnje, povećanu razinu ugode za putnike i posadu, smanjenu potrošnju goriva i smanjeni utjecaj na okoliš.]]></summary_hr><summary_en><![CDATA[The objective of the project “Green Modular Passenger Vessel for Mediterranean – GRiMM” is the development of the new design methodology for small passenger ships aimed for the operation in the Mediterranean Sea, by applying the modular concept approach. The modular concept enables the change of the ship production paradigm from the classical all-in-one approach to a parallel manufacture of different components done by highly specialized producers and a final assembly done by the local shipyard. The target vessel is considered as made of independent modules which can be combined together to achieve different characteristics in terms of ship dimensions, carrying capacity, operating conditions, fuel options and innovative energy efficient solutions. Fundamentally, the ship is made of three modules forming the ship hull, power system and superstructure. Of course this approach makes the design process much more complex than that for a single specific ship, as it has to account for all the different needs and for the associated regulatory aspects.First, an analysis of the market needs and of the corresponding ship requirements will be performed for different navigation regions in the Mediterranean Sea. Preliminary concepts based on that analysis will be proposed, while the final concepts will be developed taking into account all the aspects of ship design: hydrodynamic and propulsion efficiency, simplified manufacturing processes, ship habitability (comfort level for crew and passengers) as well as environmentally friendly energy solutions. Through this project several optimized modular passenger vessels will be proposed depending on the selected design criteria sets. In this sense it is expected that the project will result in a number of concepts depending on the market needs with reduced production costs, higher level of comfort for crew and passengers, reduced fuel consumption as well as lower environmental impact.]]></summary_en></project><project>
<id>6882</id><title_hr><![CDATA[Internet stvari: istraživanja i primjene ]]></title_hr><title_en><![CDATA[Internet of Things: Research and Applications]]></title_en><user_id>7605</user_id><user_firstLast_name>Petar Šolić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-4206</code><acronim><![CDATA[IoTRA]]></acronim><duration>19.03.2018 - 18.09.2023</duration><status>Završio</status><financ_value>277.060,09 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, Računarstvo, </scie_field_hr><scie_field_en>Electrical engineering, Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Fakultet elektrotehnike, strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Electrical Engineering, Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>22801, 2623, 7189, 25802, 28922, 865206, 866660, </team_members_id><team_members_names><![CDATA[Toni Perković, Duje Čoko, Maja Škiljo, Ana Čulić, Lea Dujić Rodić, Kristina Zovko, Ana Grubišić, ]]></team_members_names><keywords_hr><![CDATA[Internet stvari, RFID, uređaji niske potrošnje, pametna okruženja, prototipiranje uređaja]]></keywords_hr><keywords_en><![CDATA[Internet of Things (IoT), RFID, Low Power Devices, Smart Environemnt, Device Prototyping]]></keywords_en><summary_hr><![CDATA[Internet stvari je postala najistraživanija tema u području elektrotehnike i računarstva. Postojeće tehnološke infrastrukture se trenutno redizajniraju s ciljem organizacije mrežnih arhitektura potrebnih za komunikaciju milijardi uređaja u realnom vremenu, pohrane velike količine podataka i korištenja istih za izgradnju budućih pametnih okruženja. Posljedično, pojavit će se nove usluge i tehnologije koje će olakšati život.Cilj ovog projektnog prijedloga odgovara temi vizije Interneta stvari, a omogućava  smanjenje robusnosti i energetskih zahtjeva IoT uređaja, održivost i što je najvažnije primjenjivost u skoroj budućnosti. Temeljem zapaženih nedostataka postojeće tehnologije, cilj je dati nove prijedloge koje smanjuju ograničenja, te koriste stečena znanja s ciljem izrade prototipova poboljšanih uređaja. Kao posljedica, izraditi će se skupina novih poboljšanih prototipova testiranih u realnim uvjetima koje omogućuju takvu viziju.]]></summary_hr><summary_en><![CDATA[Internet of Things (IoT) became the hottest research topic in the field of electronics and computer science. New upcoming technological infrastructures are currently being redesigned in order to handle real time communication between billions of devices, storing their big data, analyzing and using the data to manipulate the future smart environments. Consequently, new services and technologies will emerge, and help in making life easier.The aim of this proposal goes in-line with the hottest research topics enabling IoT vision, while proposing new advances that make IoT technology less robust, less expensive, less power hungry, sustainable and the most important, applicable in the close future. In particular, the proposal is oriented toward gathering the state of the art IoT enabling technologies available on the market in order to provide in-depth analysis of their performances. Based on the noticed disadvantages of state of the art technologies, the goal is to provide new proposals that can enhance limitations, bring new related insights and use acquired knowledge to construct prototypes of these new enhanced devices. As a consequence, a set of new robust prototypes tested in real environments that can help in accomplishing such vision will be provided. ]]></summary_en></project><project>
<id>6883</id><title_hr><![CDATA[Razvoj novih membrana za ionsko-selektivne elektrode s dodatkom nanočestica metala i metalnih oksida]]></title_hr><title_en><![CDATA[Development of new membranes for ion-selective electrodes enriched with nanoparticles of metals and metal oxides]]></title_en><user_id>13403</user_id><user_firstLast_name>Ante Prkić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-6282</code><acronim><![CDATA[NANOISEM]]></acronim><duration>01.03.2018 - 28.02.2023</duration><status>Završio</status><financ_value>150.954,94 eur</financ_value><scie_area_hr>Prirodne znanosti, Biotehničke znanosti, Biomedicina i zdravstvo, Tehničke znanosti, </scie_area_hr><scie_area_en>Natural sciences, Biotechnical sciences, Biomedicine and health sciences, Technological sciences, </scie_area_en><scie_field_hr>Kemija, Kemijsko inženjerstvo, Biotehnologija, Biotehnologija u biomedicini, </scie_field_hr><scie_field_en>Chemistry, Chemical engineering, Biotechnology, Biotechnology in Biomedicine, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Kemijsko-tehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Chemistry and Technology]]></institution_en><team_members_id>13512, 5300, 1163, 22685, 22703, 22736, 25093, </team_members_id><team_members_names><![CDATA[Perica Bošković, Ivana Opačak, Miće Jakić, Anamarija Veljacic Veljacic, Tina Vukušić, Karmela  Zankli Kulazo, Andrea  Sedlar, ]]></team_members_names><keywords_hr><![CDATA[Ionsko-selektivne elektrode, membrane, nanočestice, potenciometrija, senzori]]></keywords_hr><keywords_en><![CDATA[Ion-selective electrodes, membranes, nanoparticles, potentiometry, sensors]]></keywords_en><summary_hr><![CDATA[Cilj projektnog prijedloga je razvoj višenamjenskih potenciometrijskih senzora u čvrstom stanju s membranama uz dodatak nanočestica metala, odnosno metalnih oksida te mikroemulzijskih gel membrana. Sekundarni cilj je razviti jednostavne potenciometrijske senzore za određivanje kemijskih vrsta od interesa (npr. kromovih specija u otpadnim vodama poslije kromiranja; kloridnih iona u prehrambenim proizvodima i sl.) koji će imati poboljšana svojstva. Poboljšana svojstva senzora očitovat će se u jednostavnijoj pripremi uzoraka za analizu (ne smeta obojenje i mutnoća uzorka), poboljšana kemijska, fizikalna i električna svojstva što će izravno poboljšati robustnost, povećati linearno dinamičko područje odziva, poboljšati vrijeme odziva, produžiti životni vijek senzora, omogućiti kontinuirano mjerenje u realnom vremenu, smanjiti troškove analize smanjenjem količine otopina čime se smanjuje i količina štetnih otpadnih kemikalija. Potom razvoj novih on-line i in-line analitičkih metoda za određivanje analita od interesa, što će poboljšati standardnu analitičku metodologiju za određivanje odabranih vrsta poboljšanjem selektivnosti, osjetljivosti, stabilnosti i trajnosti senzora. Razvoj ionsko-selektivnih elektroda izvest će se na dva plana: izrada novih membrana dodatkom nanočestica i mikroemulzijskih gel membrana te izradom novog tijela elektrode s čvrstim kontaktom, minijaturizacijom u cilju pojednostavljenja procesa proizvodnje ionsko selektivnih elektroda, odnosno povećane primjenjivosti senzora posebice kod kontinuiranog praćenja procesnih uvjeta proizvodnje, direktnim smanjenjem troškova proizvodnje što će u konačnici voditi smanjenju troškova analize.]]></summary_hr><summary_en><![CDATA[The aim of the project proposal is the development of multifunctional potentiometric sensors in solid state with membranes with the addition of nano particles, and microemulsion gel membrane. A secondary objective is to develop simple potentiometric sensors for the determination of chemical species of interest that would have improved properties. Improved sensor performance will be based on simpler preparation of samples for analysis (does not matter discoloration and turbidity of the sample), improved chemical, physical and electrical properties. Mentioned properties will directly improve the robustness, increase the linear dynamic range response, improved response time, extended life sensors, allow continuous measurement in real time, lower the costs of the analysis by reducing the amount of solution, which reduces the amount of harmful waste chemicals. Then the development of new on-line and in-line analytical method for the determination of an analyte of interest, which will improve the standard analytical methodology for the determination of selected species by improving the selectivity, sensitivity, stability and durability of the sensor. The development of ion-selective electrodes will be performed by the development of new membrane with addition of nano particles and microemulsion gel membrane. Following step will be creation of a new body of the electrode with solid contact, miniaturization in order to simplify the manufacturing process of ion selective electrodes or increased applicability of sensors especially for the continuous monitoring of process conditions of production, direct reduction in production costs, which will ultimately lead to reductions in the cost analysis. ]]></summary_en></project><project>
<id>6891</id><title_hr><![CDATA[Mikrobiom glavate želve (Caretta caretta): uvid u epizoičke i endozoičke zajednice]]></title_hr><title_en><![CDATA[Loggerhead sea turtle (Caretta caretta) microbiome: insight into endozoic and epizoic communities]]></title_en><user_id>4337</user_id><user_firstLast_name>Sunčica Bosak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-5635</code><acronim><![CDATA[TurtleBIOME]]></acronim><duration>01.03.2018 - 31.08.2023</duration><status>Završio</status><financ_value>306.011,02 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>17842, 19415, 25309, 855403, 858354, </team_members_id><team_members_names><![CDATA[Maja Mejdandžić, Romana Gračan, Klara Filek, Marta Zizek, Lucija Kanjer, ]]></team_members_names><keywords_hr><![CDATA[Mikrobiom, dijatomeje, morske kornjače, morska mikrobna ekologija, epizojske zajednice]]></keywords_hr><keywords_en><![CDATA[Microbiome, diatoms, sea turtles, marine microbial ecology, epizoic community  ]]></keywords_en><summary_hr><![CDATA[Mikrobiom predstavlja vitalni sustav koji se počeo razmatrati kroz paradigmu holobionta i opisivati kao cjelokupan sustav biljke/životinje zajedno s mikroorganizmima koji žive unutar ili na površini organizma. Morske kornjače su karizmatični morski kralješnjaci, među najugroženijim vrstama na svijetu. Nedavno je otkriveno da oklop morskih kornjača naseljavaju jedinstvene i brojne zajednice fotosintetskih mikroorganizama od kojih su najznačajnije dijatomeje. Jedinstvene vrste epibiontskih dijatomeja koloniziraju vanjske površine morskih kornjača, kožu i oklop, a novootkrivene epizoičke svojte pronađene su na svim vrstama morskih kornjača diljem svijeta. Unatoč važnosti i fundamentalnoj ulozi mikroorganizama u fiziološkim procesima morskih kornjača, u potpunosti nedostaju podaci o epibiontskim bakterijama,dok je sastav bakterijskih zajednica u probavilu samo sporadično opisan. Znanstveni doprinos predloženog projekta je pružiti jasnu sliku mikrobiološkog sastava površinskog biofilma i mikrobioma probavila glavatih želvi koje su najbrojnija vrsta morskih kornjača u Jadranu i Mediteranu. Kako bi ispunili zadani cilj koristiti ćemo najsuvremeniji molekularni pristup, ali i uhodane tradicionalne metode. Ovaj uspostavni istraživački projekt okuplja mlade i kompetentne znanstvenike u jedinstvenu sinergističku skupinu koja je sposobna postaviti temelj novom interdisciplinarnom istraživačkom pristupu u ekologiji i zaštiti mora te biologiji mora. Predloženi projekt će pružiti temeljne podatke o sastavu zajednica mikrobioma glavatih želvi koje će nadograditi postojeće znanje o ponašanju morskih kornjača, njihovim migracijskim putevima i staništima ishrane te pridonijeti dugotrajnim planovima zaštite morskih kornjača. Znanja prikupljena ovim projektom mogu se u budućnosti primijeniti za praćenje i zaštitu i drugih ugroženih morskih kralješnjaka poput dupina ili kitova, posebice jer će omogućiti nove spoznaje u svjetlu globalnih klimatskih promjena.]]></summary_hr><summary_en><![CDATA[The microbiome has become increasingly regarded as a vital system, currently viewed through paradigm of holobiont, describing the plant/animal together with the organisms living within or on their surface. Sea turtles are charismatic marine vertebrates and among the most endangered animals in the world. Recent findings show that sea turtles harbour unique and abundant epizoic microbial communities on their carapaces. Sea turtle-associated diatoms show ability to colonize the surface of animal tissues, both skin and carapace and new species/genera have been described worldwide from all sea turtle species. In spite of their importance and essential role in the host animal physiological functions there are huge knowledge gaps on the sea turtle holobiont. Our proposal aims to describe sea turtle microbial biodiversity by studying surface biofilm community and the gut microbiome of loggerhead turtles occurring in the Adriatic Sea. We will achieve this goal by pairing state-of-the-art culture-independent molecular approach with classic research methods. This installation research project aims to combine efforts of young and competent scientists in a single cohesive group that will set out the foundation for an interdisciplinary research approach in fields of marine ecology, marine biology and conservation. The proposed study will provide baseline data on the composition of loggerhead microbiome that might be integrated with the existing information on sea turtle behaviour, their migration routes, and foraging habitats thus contributing to a long term plans for sea turtle protection. Provided set of tools and methods may be applied in the future to other endangered marine animal-microbe associations in the rapidly changing world we live in.]]></summary_en></project><project>
<id>6896</id><title_hr><![CDATA[Prema pouzdanoj raspodijeljenoj upravljačkoj ravnini za programirljive komunikacijske mreže]]></title_hr><title_en><![CDATA[Towards Reliable Distributed Control Plane for Programmable Communication Networks]]></title_en><user_id>2572</user_id><user_firstLast_name>Ognjen Dobrijević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-1569</code><acronim><![CDATA[reCREATE]]></acronim><duration>01.03.2018 - 28.02.2023</duration><status>Prekinut</status><financ_value>108.697,86 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, Računarstvo, </scie_field_hr><scie_field_en>Electrical engineering, Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>4569, 3189, 22572, </team_members_id><team_members_names><![CDATA[Marija Furdek, Matija  Džanko, Haris Hodzic, ]]></team_members_names><keywords_hr><![CDATA[Virtualizacija mreže, programski upravljano umrežavanje, raspodijeljena upravljačka ravnina, mrežni hipervizor, pouzdanost, otpornost na kvarove]]></keywords_hr><keywords_en><![CDATA[Network virtualization, software-defined networking, distributed control plane, network hypervisor, reliability, failure resiliency]]></keywords_en><summary_hr><![CDATA[Komunikacijske mreže razvijaju se prema svojoj petoj generaciji, koja mora zadovoljiti stroge zahtjeve vezane uz raspoloživost usluga i komunikacijsko kašnjenje. Iz tih razloga, buduće mreže će se oslanjati na paradigme programski upravljanog umrežavanja (SDN) i virtualizacije mreže, za koje se predviđa da će unaprijediti prilagodljivost mreža. SDN je specifičan zbog odvajanja funkcija upravljanja mrežom iz uređaja podatkovne ravnine te njihove implementacije u vidu SDN upravljačkog uređaja (SDNC). Sa SDN-om, aplikacije treće strane mogu programirati mreže, pri čemu koriste otvorena sučelja izložena od strane SDNC-ova. Mrežni hipervizori omogućuju virtualizaciju apstrahiranjem mrežnih resursa u izolirane logičke segmente, pri čemu obavljaju i ulogu posrednika između više SDNC instanci i uređaja podatkovne ravnine. U takvim mrežama, osiguravanje otpornosti upravljačke ravnine na kvarove neophodan je preduvjet za ispravan rad mreže i njezinih usluga.Glavni znanstveni cilj ovog projekta je predložiti pristupe u projektiranju pouzdane SDN upravljačke ravnine koja obuhvaća više instanci SDNC-a i mrežnog hipervizora. U prvom dijelu istraživanja ispitat ćemo kritičnost komponenti upravljačke ravnine s obzirom na različite vrste kvarova i predložiti novu mjeru dostupnosti upravljačke ravnine. Zatim ćemo formulirati problem raspoređivanja upravljačkih uređaja i hipervizora, koji podrazumijeva otpornost na kvarove, te razviti optimizacijske algoritme za njegovo rješavanje. Rješenja tog problema određuju broj i fizičke lokacije instanci SDNC-a i mrežnog hipervizora, a pritom dodjeljuju dovoljno rezervnih resursa za slučaj pojava kvarova. U drugom dijelu istraživanja definirat ćemo model sinkronizacije stanja mreže za raspodijeljenu SDN upravljačku ravninu, kao i generičke postupke za upravljanje kvarovima. Svi predloženi pristupi eksperimentalno će se vrednovati u sklopu istraživačkog prototipa s modernom mrežnom opremom koja ima podršku za SDN.]]></summary_hr><summary_en><![CDATA[Communication networks are evolving towards their fifth generation, which needs to meet the rigorous requirements on service availability and communication latency. For these reasons, future networks will rely on the software-defined networking (SDN) and network virtualization paradigms, which are anticipated to enhance network flexibility. SDN is specific for its separation of the network control functions from data plane devices and then implementing the functions in an SDN controller (SDNC). With SDN, the networks are becoming programmable by third party applications, which utilize open interfaces exposed by SDNCs. Network hypervisors enable virtualization by abstracting network resources into isolated logical segments and by acting as mediators between multiple SDNC instances and data plane devices. In such networks, ensuring the control plane resilience to failures is an essential precondition for the accurate operation of the network and its services.The main scientific objective of this project is to propose approaches for the design of a reliable SDN control plane that encompasses multiple SDNC and network hypervisor instances. In the first research track, we will examine the criticality of control plane components against different failure types and specify a novel control plane availability measure. Then, we will formulate the controller and hypervisor placement problem that considers resilience to failures and develop optimization algorithms to solve it. The problem solutions determine the number and physical locations of SDNC and network hypervisor instances, while also allocating adequate backup resources in case of failures. In the second research track, we will specify a network state synchronization model for the distributed SDN control plane, as well as generic control procedures for dealing with failures. All the proposed approaches will be experimentally evaluated on a research testbed with the modern SDN-supported networking equipment.]]></summary_en></project><project>
<id>6897</id><title_hr><![CDATA[Neonikotinoidi i bakar u mediteranskoj poljoprivredi – učinci na neciljanu faunu beskralješnjaka kroz trofičke interakcije]]></title_hr><title_en><![CDATA[Neonicotinoids and Copper in the Mediterranean Agriculture - their effects on non-target invertebrates through trophic interactions]]></title_en><user_id>12919</user_id><user_firstLast_name>Lucija Šerić Jelaska</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-1046</code><acronim><![CDATA[MEDITERATRI]]></acronim><duration>01.03.2018 - 31.08.2023</duration><status>Završio</status><financ_value>264.803,90 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, Kemija, </scie_field_hr><scie_field_en>Biology, Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>12409, 12892, 25091, 28927, </team_members_id><team_members_names><![CDATA[Tomislav Kos, Mišel Jelić, Barbara  Anđelić , Lara Ivanković, ]]></team_members_names><keywords_hr><![CDATA[korisna fauna beskralješnjaka, mediteranska ekosustavi, održivo upravljanje, trofičke mreža, trčci,pauci, štrige]]></keywords_hr><keywords_en><![CDATA[Beneficial invertebrate fauna, Mediterranean ecosystems, sustainable management, trophic network, carabids, spiders, centipedes]]></keywords_en><summary_hr><![CDATA[Neonikotinoidi su relativno novi i najčešće korišteni insekticidi u svijetu. Za razliku od njih, primjena bakra (Cu) ima dugu povijest u zaštiti bilja, osobito u mediteranskoj poljoprivredi (npr. u vinogradima). Novija istraživanja su pokazala brojne negativne učinke na vrste koje nisu cilj djelovanja pesticida (npr. gujavice, ptice) i ukazala na problem očuvanja vrsta korisnih u biološkoj kontroli kao što su predatori (npr. kornjaši trčci, pauci i štrige) koji su ujedno ključni za pravilno funkcioniranje ekosustava. Velika biološka raznolikost u tlu i složene trofičke interakcije nisu dovoljno istražene i stoga je teško predvidjeti sve moguće negativne učinke pesticida. Slabo poznavanje hranidbenih lanaca kod beskralješnjaka dijelom je posljedica ograničenih mogućnosti koje nude tradicionalne metode poput mikroskopskog pregleda. Detaljne trofičke analize danas su moguće pomoću najnovijih molekularnih tehnika kao što je nova generacija sekvenciranja (NGS). Cilj ovog istraživanja je utvrditi trofičke odnose na terenu analizom probavila predatora beskralješnjaka, utvrditi vektore za prijenos pesticida putem ishrane te izravan utjecaj primjene pesticida na preživljavanje i raznolikost predatora i plijena. Terensko istraživanje obavit će se u mediteranskim poljoprivrednim ekosustavima, vinogradima i maslinicima, gdje se koriste oba pesticida, te u prirodnom staništu bez gospodarenja. NGS-om će se utvrditi kompletna ishrana predatora i ujedno će se generirati podaci o DNA sljedovima za brojne vrste beskralježnjaka koji će biti pohranjeni u bazama projekta &#39;&#39;The International Barcode of Life&#39;&#39;. LC-MS / MS i ICP-MS tehnikom kvantificirat će se ostatci neonikotinoida i izmjeriti koncentracije Cu u tlu i životinjama na različitim trofičkim razinama. Rezultati će uvelike doprinijeti procjeni rizika primjene i širenja neonikotinida i Cu u ekosustavu te znanju o održivosti  beskralješnjaka predatora kao ključne skupine u integriranoj zaštiti bilja u poljoprivredi.]]></summary_hr><summary_en><![CDATA[Neonicotinoids are the most commonly used insecticides worldwide, and are relatively new, whereas application of Copper (Cu) has a long history, especially in the Mediterranean agriculture, (e.g. in vineyards). Recent studies have shown their negative effects on non-target species (e.g. earthworms, insects, birds) and raised great concerns about survival of beneficial predatory species (e.g. carabid beetles, spiders and centipedes), important for pest control and essential for healthy ecosystem functioning. High biodiversity in the soil and very complex food webs are far from being well explored and thus it is hard to predict all possible negative effects of pesticides. This knowledge gap reflects, in part, the fact that traditional methods such as microscopic inspection cannot detect many trophic interactions. Recently, complex food web analysis has become possible with the advent of molecular techniques as Next Generation Sequencing NGS. By analysing trophic interactions of soil invertebrates, the aim is to identify vectors that transfer toxicant to general predators and to connect application of pesticides with the predator and prey survival and diversity in the field. Field survey will take place within Mediterranean agriculture ecosystems, in vineyards and olive orchards, treated with both pesticides and in pristine habitat. NGS will be used to reveal the complete diet of predatory invertebrates in the field. Besides, it will generate valuable DNA sequence data for numerous invertebrate species that will be deposited in “The International Barcode of Life“ databases. LC-MS/MS and ICP-MS technique will quantify neonicotinoid residues and Cu concentrations in soil and in animals representing different trophic guilds. The results will greatly contribute to the risk assessment of neonicotionid and copper proliferation in the ecosystem and to the knowledge on the overall field sustainability of predatory invertebrates, a key group in integrated pest control.]]></summary_en></project><project>
<id>6899</id><title_hr><![CDATA[Višerazinski pristup govornom diskursu u jezičnom razvoju]]></title_hr><title_en><![CDATA[Multilevel approach to spoken discourse in language development]]></title_en><user_id>6147</user_id><user_firstLast_name>Gordana Hržica</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-6603</code><acronim><![CDATA[MultiDis]]></acronim><duration>01.01.2018 - 31.12.2023</duration><status>Završio</status><financ_value>131.404,87 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Logopedija, </scie_field_hr><scie_field_en>Logopedics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Edukacijsko-rehabilitacijski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Education and Rehabilitation Sciences]]></institution_en><team_members_id>22675, 22678, 3664, 17791, 22665, 25250, 20102, 25249, 23925, 27955, 5121, </team_members_id><team_members_names><![CDATA[Gordana Dobravac, Nada Poropat Jeletić, Tomislava Bošnjak Botica, Marina Olujić, Marina Camber, Sara Košutar, Ivana Trtanj, Eliana Moscarda Mirković, Ana Leko Krhen, Matea Kramarić, Katarina Aladrović Slovaček, ]]></team_members_names><keywords_hr><![CDATA[govorni diskurs, jezični razvoj, mjere za procjenu diskursa, višerazinski pristup, dvojezični govornici, narušen jezični razvoj, SES]]></keywords_hr><keywords_en><![CDATA[spoken discourse, language development, measures for discourse assessment, multi-level approach, bilingualspeakers, atypical language development, SES]]></keywords_en><summary_hr><![CDATA[U psiholingvistici i primijenjenoj lingvistici procjena proizvedenog diskursa smatra se pouzdanim sredstvom procjene jezičnog znanja (Schneider i sur., 2006; Botting, 2002). Prikupljanje diskursnih uzoraka ekološki je valjano sredstvo procjene jer odražava uporabu jezika u svakodnevnom okruženju. Među različitim pristupima diskursu ističe se višerazinski pristup. Ovaj je pristup teorijska smjernica projektnog prijedloga, iako do sada nije bio primijenjen na područje jezičnog razvoja. Većina se teorija i mjera analize diskursa temelje na engleskom jeziku zbog čega postoji potreba za validacijom podatcima iz tipološki različitih jezika. U ovom projektu za istraživanja će se koristiti postojeći resursi, ali i nadopuniti ili u potpunosti razviti novi (leksičke baze i korpusi). Spoznaje koje će biti rezultat analize tih resursa, poput onih o pojavnosti i čestotnosti različitih struktura u hrvatskom jeziku u određenom razvojnom periodu kod različitih populacija, kao i prilagodbom automatiziranih korpusnih mjera hrvatskome, stvorit će se preduvjeti za razvoj novog materijala za poticanje proizvodnje diskursa. Materijal će se temeljiti na slikovnim predlošcima te će se rabiti računalno uz automatizaciju snimanja, podršku pri transkripciji te izračun mjera za procjenu diskursa. Zbog temeljenosti na prethodnim istraživanjima te psihometrijskih karakteristika materijal će se moći rabiti za jezičnu procjenu, a validacijsko će ispitivanje pružiti pouzdane podatke o razvoju diskursa za različite skupine govornika (jednojezični, dvojezični, narušen jezični razvoj, različit SES) u višerazinskom pristupu.Očekuje se da će se ovim pristupom u projektu a. steći uvid u kognitivne i jezične aspekte ključne za oblikovanje diskursa, b. doprinijeti međunarodnim znanstvenim teorijama i pristupima, c. razviti ili nadopuniti te učiniti javno dostupnima jezične resurse pogodne za druga lingvistička istraživanja te d. doprinijeti spoznajama područjima jezičnog obrazovanja i jezične procjene.]]></summary_hr><summary_en><![CDATA[In the field of psycholinguistics and applied linguistics, discourse analyses have been considered a valuable tool for assessing language knowledge (Schneider et al., 2006; Botting, 2002). The elicitation of discourse samples is an ecologically valid assessment tool since it reflects conversation in everyday environment. A multi-level approach is the main framework of this project proposal. Most of the theories, approaches and discourse analyses measures are based on English language so there is a need for their validation in typologically different languages. In this project new resources will be developed and some existing updated (i.e., lexical database and different corpora). Their analyses will lead to new findings, such as frequency and types of language structures in Croatian in a particular period during language development and in different populations, as well as to development of new automatized corpus measures. These findings will be crucial for development of the new discourse assessment material. Material will be based on picture stimuli in a computer-based application. Application will allow for the automatization of the recording procedure, transcription support and automatic calculation of discourse measures. As the material is grounded in research findings and validated, it will be ready for use as language assessment tool. Validity studies will provide reliable data on discourse development for different groups of speakers (monolingual, bilingual, atypical language development, different SES).It is expected that the project will a. provide a reliable insight into the cognitive and linguistic aspects that underlie the formation of a discourse, b. contribute to the body of research concentrated mainly on English data, c. develop or update language resources in open access needed for diverse linguistic research and d. provide knowledge relevant for language education and language assessment.]]></summary_en></project><project>
<id>6901</id><title_hr><![CDATA[Primjena naprednog peer-to-peer koncepta za trgovanje električnom energijom]]></title_hr><title_en><![CDATA[Implementation of Peer-to-Peer Advanced Concept for Electricity Trading]]></title_en><user_id>22498</user_id><user_firstLast_name>Ivan Rajšl</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-4068</code><acronim><![CDATA[IMPACT]]></acronim><duration>01.07.2018 - 30.06.2023</duration><status>Završio</status><financ_value>160.431,96 eur</financ_value><scie_area_hr>Tehničke znanosti, Društvene znanosti, </scie_area_hr><scie_area_en>Technological sciences, Social sciences, </scie_area_en><scie_field_hr>Elektrotehnika, Ekonomija, Informacijske znanosti, </scie_field_hr><scie_field_en>Electrical engineering, Economy, Information sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>22643, 20495, 22654, 22583, 22566, 22502, 903, 20517, 25411, 25407, </team_members_id><team_members_names><![CDATA[Zlatko Zmijarević, Zoran  Kordić, Perica Ilak, Marin Cerjan, Andrea Brajko, Goran Grdenić, Stjepan Sučić, Lin Herencic, Hrvoje Keko, Matej Cvitanović, ]]></team_members_names><keywords_hr><![CDATA[blockchain tehnologija, energetska demokracija, građanska energija, mikromreža, protrošači električne energije, peer-to-peer trgovanje]]></keywords_hr><keywords_en><![CDATA[blockchain technology, community energy, electricity prosumers, energy democracy, microgrid, peer-to-peer trading]]></keywords_en><summary_hr><![CDATA[Današnje moderne distribucijske mreže djelomično su transformirane iz pasivnih u aktivne posebno pod utjecajem značajne integracije OIE. Decentralizacija distribucijskih mreža jedan je od preduvjeta za energetsku demokraciju i poticaj malim korisnicima mreže da sudjeluju u trgovanju električnom energijom uvođenjem koncepta u kojem će pojedini korisnici električne energije, kao što su krajnji potrošači, proizvođači ili protrošači, trgovati električnom energijom unutar mikromrežnih zajednica. Takvo tržišno okruženje može se postići blockchain tehnologijom primijenjenom za peer-to-peer (P2P) transakcijske platforme.Budući da u takvom načinu trgovanja treće strane nisu nužne (preprodavači, operator tržišta), troškovi transakcija mogu se smanjiti, a procesi ubrzati. Blockchain Pametni ugovori automatski mogu pokrenuti transakciju između tržišnih sudionika (peer-ova) na temelju unaprijed definiranih individualnih i mrežnih parametra.Osim što se koristi za izvršavanje novčanih transakcija i reguliranje tokova snaga, predloženi P2P koncept također pruža osnovu za napredna mjerenja i naplate.Projekt ima za cilj uspostavu potpuno decentraliziranog energetskog sustava u kojem se ugovori o izravnoj trgovini električnom energijom između krajnjih korisnika mreže provode automatski.U prvom dijelu projekta provest će se detaljna analiza postojećeg tržišnog okruženja kako bi se ustanovila najbolja praksa primjene P2P koncepta u distribucijskim sustavima te razvio teorijski okvir za koncept P2P trgovanja električnom energijom.Teorijski koncept bit će osnova za drugi dio koji će se usredotočiti na razvoj novih algoritama i simulacijskih modela P2P koncepta trgovanja električnom energijom.Treći dio projekta će se usredotočiti na laboratorijsku implementaciju razvijenih simulacijskih modela i provedbu ispitivanja u SGLab laboratoriju FER-a.Rezultati naprednog koncepta P2P trgovine električnom energijom će se u završnoj fazi primijeniti u mikromreži na otoku Krku, Hrvatska.]]></summary_hr><summary_en><![CDATA[Today modern distribution grids have transformed partly from passive to active network especially due to significant recent RES integration. Decentralisation of distribution networks, can boost energy democracy and stimulate small electricity users to participate in trading electricity with introduction of concept where individual electricity users, such as end consumers, producers or prosumers will trade electricity within community microgrids. Such community energy market environment can be achieved through the blockchain technology for peer-to-peer (P2P) transaction platforms. Since third-party intermediaries (electricity retailers, market operator) are no longer needed the transaction costs could be lowered and processes accelerated. Blockchain’s smart contracts would automatically initiate transaction between peers based on predefined individual rules concerning desired network parameters. Besides being used to execute energy supply transactions and regulate power flows, proposed P2P concept also provides the basis for advanced metering, billing and clearing processes.The project aims at establishing a fully decentralised energy system in which energy supply contracts are made directly between end user of electricity that are carried out automatically. In the first part of the project detailed analysis of the existing market environment will be conducted in order to detect best practices of P2P in distribution systems and to develop theoretical framework for P2P electricity trading concept. Theoretical concept will be basis for the second part that will focus on developing novel algorithms, and simulation models of P2P electricity trading concept. The third part of the project will focus on laboratory implementation of developed simulation models and execution of testing in the SGLab laboratory on FER. Third part will result with advanced concept of P2P electricity trading that will be implemented into the real life site on microgrid in Krk Island, Croatia.]]></summary_en></project><project>
<id>6902</id><title_hr><![CDATA[Eksperimentalna i numerička istraživanja mehanizama u nesaturiranim geomaterijalima]]></title_hr><title_en><![CDATA[Experimental and numerical investigations of mechanisms in unsaturated geomaterials]]></title_en><user_id>22682</user_id><user_firstLast_name>Nataša Štambuk Cvitanović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-3429</code><acronim><![CDATA[UNSAT1]]></acronim><duration>01.03.2018 - 31.08.2023</duration><status>Završio</status><financ_value>190.473,32 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Građevinarstvo, </scie_field_hr><scie_field_en>Civil engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu Fakultet građevinarstva, arhitekture i geodezije]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Civil Engineering, Architecture and Geodesy]]></institution_en><team_members_id>13219, 22635, 25729, </team_members_id><team_members_names><![CDATA[Mijo Nikolić, Goran Vlastelica, Ana Raič, ]]></team_members_names><keywords_hr><![CDATA[Geomaterijali, Meke stijene, Nesaturirani uvjeti, Usis, SWCC krivulja, Rastrošba,  Eksperimentalna istraživanja, Numeričko modeliranje]]></keywords_hr><keywords_en><![CDATA[Geomaterials, Soft rock, Unsaturated conditions, Suction, SWCC curve, Weathering, Experimental investigations, Numerical modelling]]></keywords_en><summary_hr><![CDATA[Rastrošba, kao degradacija stijene pod izravnim djelovanjem uvjeta okoliša i ljudske aktivnosti u razdoblju inženjerske skale vremena, je ključan proces koji nadzire druge geomorfološke, ekološke i društvene procese i zbivanja. Meke stijene poput lapora, vrlo rasprostranjene u području Mediterana, posebno su podložne rastrošbi. Pod djelovanjem čimbenika rastrošbe meke stijene se degradiraju sve do sitnozrnog materijala, uz što su vezani problemi održivosti okoliša te stabilnosti, nosivosti i trajnosti. Prema novijim znanstvenim spoznajama, značajan doprinos razvoju rastrošbe daje proces diferencijalnog usisa i njime izazvanog diferencijalnog bubrenja, koji se javlja u nesaturiranim uvjetima. Posljedica diferencijalnog bubrenja je razvoj vlačnih i posmičnih naprezanja koja dovode do rastrošbe. Stoga je cilj ovog projekta istražiti i modelirati mehanizme rastrošbe s aspekta usisa, te povezati dobivene spoznaje s brojnim istraživanjima čimbenika rastrošbe prikupljenim sustavnim radom na Fakultetu u prethodnom razdoblju. Posmična čvrstoća i deformabilnost u nesaturiranim uvjetima za zadano stanje sukcije, kao i karakteristične krivulje sadržaja vode u tlu ovisno o naprezanju (SDSWCC-Stress Dependent Soil Water Characteristic Curve), odredit će se eksperimentalno sofisticiranom istraživačkom opremom na još neispitanim materijalima meke stijene iz obalnog područja RH. Istovremeno će se provesti i sva popratna ispitivanja te povezati nova i postojeća baza podataka. Dobiveni rezultati ugradit će se u postojeći numerički model (Plaxis), a dodatno će se razviti i novi numerički model temeljen na diskretnom pristupu koji može obuhvatiti mehanizam loma u geomaterijalima u nezasićenim uvjetima protoka. Time bi se unaprijedilo područje poznavanja mehanizama rastrošbe u geomaterijalima općenito i omogućila održiva projektna rješenja. Novu vrijednost predstavlja i formirana istraživačka grupa s potrebnim resursima.]]></summary_hr><summary_en><![CDATA[Weathering as rock degradation under the direct influence of environmental conditions and human activity in the engineering period of time, is a key process that affects geomorphologic, ecologic and societal processes and events. Soft rocks, such as marl, are very common in the Mediterranean and particularly susceptible to weathering. Under the influence of many different processes, weathering degrades soft rocks to fine-grained material, coupled with environmental sustainability, stability, bearing capacity and durability issues. According to recent scientific findings, a significant contributor to the development of weathering is the process of differential suction and induced differential swelling, which occurs in unsaturated conditions. The consequences of differential swelling are development of tensile and shear stresses that cause weathering. Therefore, the aim of this project is to investigate and model the mechanisms of weathering from the aspect of suction, and to link the acquired new findings with the significant previous research carried out at the Faculty. The shear strength and deformability in unsaturated conditions for the given degree of suction, and the characteristic SDSWCC curves (Stress Dependent Soil Water Characteristic Curve) will be determined by sophisticated testing equipment on still unexamined soft rock material from the Croatian coastal area. At the same time all “accompanying” tests will be carried out and new and existing databases will be linked. The results obtained will be incorporated into the existing numerical model (Plaxis) and into additionally developed new numerical model based on a discrete approach, which will include the fracture mechanism in geomaterials in unsaturated flow conditions. This will significantly improve the knowledge of weathering mechanisms in geomaterials and enable sustainable project solutions. A newly formed research group with the necessary resources provides additional value of the proposed project.]]></summary_en></project><project>
<id>6910</id><title_hr><![CDATA[Misterij subtalamusa - anatomska podjela subtalamičke jezgre]]></title_hr><title_en><![CDATA[Mystery of subthalamus - anatomical division of the subthalamic nucleus]]></title_en><user_id>4125</user_id><user_firstLast_name>Goran Sedmak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-7578</code><acronim><![CDATA[3STAN]]></acronim><duration>01.06.2018 - 31.05.2023</duration><status>Prekinut</status><financ_value>264.782,00 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>17841, 4972, 22795, 25257, </team_members_id><team_members_names><![CDATA[Andrija Štajduhar, Fadi Almahariq, Ivana Jurjević, Ema Bokulić, ]]></team_members_names><keywords_hr><![CDATA[subtalamus, Parkinsonova bolest, DBS, razvojna neurobiologija, MRI, neuroanatomija]]></keywords_hr><keywords_en><![CDATA[subthalamus, Parkinson&#39;s disease, DBS, developmental neurobiology, MRI, neuroanatomy]]></keywords_en><summary_hr><![CDATA[Subtalamus je trenutno jedna od klinički najzanimljivijih struktura bazalnih ganglija. Neurokirurško stimuliranje subtalamičke jezgre pomoglo je mnogim bolesnicima s Parkinsonovom bolesti otpornom na levodopu, no dovelo je i do neželjenih nuspojava. Nuspojave su posljedica stimuliranja neželjenih dijelova subtalamičke jezgre. Iako je u kliničkoj praksi uvriježena podjela subtalamičke jezgre u tri segmenta, postoje mnoga istraživanja koja osporavaju tu tvrdnju. Prva studija o podjeli subtalamičke jezgre objavljena je 1925. godine. Od tada pa do danas objavljene su 43 studije na čovjeku i primatima koje se bave ovom temom koristeći različite metode. Pregledom ovih studija pokazalo se da taj zaključak nije posve opravdan. Naime, samo manji broj studija (4) zagovara tri segmenta subtalamičke jezgre, a broj segmenata seže od 0 do 4. Zbog izrazite kliničke značajnosti subtalamičke jezgre i nedosljednosti u opisu broja segmenata subtalamičke jezgre, u predloženom istraživanju analizirati ćemo podjelu subtalamičke jezgre pomoću klasičnih histoloških metoda (npr. Nissl, Gallyas), modernim histološkim metodama (imunohistokemija i in-situ hibridizacija), metodama slikovnog prikaza mozga (strukturni MR, DTI MR) i modernim metodama molekularne biologije. Za kvantitativnu histološku analizu koristiti ćemo stereološku metodu. Također u sklopu ovog projekta nastaviti ćemo razvoj i testiranje programskog rješenja za automatsko prepoznavanje i kvantifikaciju neurona na histološkim preparatima. U prvoj fazi projekta analizirati ćemo post-mortem uzorke subtalamičke jezgre pomoću histoloških metoda i strukturnih MR metoda. U drugoj fazi projekta korelirati ćemo dobivene post-mortem histološke i MR rezultate s MR nalazima subtalamičke jezgre u zdravih dobrovoljaca u svrhu izrade prostorne mape subtalamičke jezgre in-vivo. U trećoj fazi korelirati ćemo podatke iz prve dvije faza s MR nalazima pacijenata oboljelih od Parkinsonove bolesti prije i nakon duboke mozgovne stimulacije.]]></summary_hr><summary_en><![CDATA[The subthalamus is clinically one of the most important parts of the basal ganglia. Neurosurgical stimulation of the subthalamic nucleus has significantly helped patients with resistant levodopa treatment. However, it also led to many side effects. Side effects are result of unwanted stimulation of other parts of subthalamic nucleus. Although, in clinical use the subthalamic nucleus is divided in three parts, there are many studies which do not support this conclusion. The first study about its subdivision was conducted in 1925. Since then, 43 studies have addressed this issue using human or primate samples and various different methods. A survey of these studies showed that three partite division of subthalamus is not supported by evidence. Only small number of studies have divided subthalamus into 3 segments (4 studies), and number of segments spans from 0 to 4. Due to the significant importance of subthalamus and inconsistencies in its division, in the proposed research we will conduct analysis of anatomical subdivision of subthalamic nucleus using classical histological methods (e.g. Nissl, Gallyas), modern histological methods (e.g. immunohistochemistry, in-situ hybridization); MR imaging methods (e.g. structural MR, DTI MR) and modern molecular biology methods. The quantification of neurons will be done using stereological approach. Furthermore, within this project we will continue to develop and test the program solution for automatic neuron recognition and counting on histological slides. In the first phase of the project we will analyse post-mortem samples of subthalamic nucleus using histological and MR techniques. In the second phase we will correlate data from the post-mortem part with the MR finding of subthalamic nucleus in healthy volunteers in order to develop spatial map of subthalamic nucleus. In the third phase we will correlate the data from first two phases with the MR findings of Parkinsonian patients prior and after the deep brain stimulation.]]></summary_en></project><project>
<id>6912</id><title_hr><![CDATA[Bilinogojstvom do sekundarnih biljnih metabolita: primjena mineralnih hraniva i elicitora za povećanje koncentracije fenola u listu masline]]></title_hr><title_en><![CDATA[Phytochemical Farming: Mineral Nutrients and Elicitors Application to Enhance Olive Leaf Phenolics]]></title_en><user_id>12403</user_id><user_firstLast_name>Igor Pasković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-8464</code><acronim><![CDATA[PhytoFarmOL]]></acronim><duration>01.12.2017 - 31.05.2023</duration><status>Završio</status><financ_value>265.438,93 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, Biotehnologija, </scie_field_hr><scie_field_en>Agriculture, Biotechnology, </scie_field_en><institution_hr><![CDATA[Institut za poljoprivredu i turizam]]></institution_hr><institution_en><![CDATA[Institute of Agriculture and Tourism in Poreč]]></institution_en><team_members_id>19496, 22584, 22579, 25397, 25433, 27540, 19478, 855521, 26869, 865042, </team_members_id><team_members_names><![CDATA[Sunčana Simonić-Kocijan, Joško Kaliterna, Paula Žurga, Valerija Majetić Germek, Kristina Grozić, Šime Marcelić, maja Kinkela Devčić, Marin Cukrov, Nikolina Vidović, Marija Polić Pasković, ]]></team_members_names><keywords_hr><![CDATA[ishrana bilja, list masline, oleuropein, paunovo oko, oralno zdravlje]]></keywords_hr><keywords_en><![CDATA[plant nutrition, olive leaf, oleuropein, olive leaf spot, oral health]]></keywords_en><summary_hr><![CDATA[Fenolni spojevi oleuropein i hidroksitirosol smatraju se glavnim aktivnim spojevima lista masline za koje je dokazano antikancerogeno, protuupalno i antimikrobno djelovanje. Oleuropein i hidroksitirosol, ali i ostali fenoli, imaju specifičnu ulogu u zaštiti bilja i povećanju otpornosti na fitopatogene gljive što može biti od presudne važnosti za održivi uzgoj maslina općenito. Fenoli i polifenoli su sveprisutni spojevi u biljkama koji igraju važnu ulogu u obrambenom mehanizmu biljke domaćina u odnosu na filamentozne gljive. Važnost fenola, pored povećanja otpornosti biljke na patogene, očituje se i u proizvodnji funkcionalne hrane i nutraceutika te lijekova na prirodnoj bazi za liječenje oralnih bolesti. Potreba za pronalaskom novih terapijskih postupaka u liječenju patoloških stanja usne šupljine dovela je do povećanog interesa za upotrebu prirodnih supstrata.Dokazano je da poljoprivredna praksa može povećati sadržaj fenola u listu masline. Samo je nekoliko istraživanja do sada bilo usmjereno na proučavanje utjecaja mineralne ishrane na sastav fenola u listu masline. U ovom projektu planira se provesti cijeli niz eksperimenata kako bi se utvrdio utjecaj određenih mineralnih hraniva (N, Ca, Mg, Mn, Zn, Cu i B) i elicitora (fosfit i kalijev silikat) na sastav fenola u listu masline kod različitih sorata. Također ocijenit će se i utjecaj prethodnog odabranog mineralnog hraniva ili elicitora, koji se pokaže kao najučinkovitiji u povećanju razine fenola, na razvoj bolesti paunovo oko koje uzrokuje fitopatogena gljiva Venturia oleaginea (sin. Spilocaea oleaginea). Razvoj bolesti pratit će se na tretiranim maslinama u polju ili kontroliranim uvjetima u plasteniku. Učinak najboljeg tretmana bit će ispitan kroz kvalitetu maslinovog ulja na sorti Leccino uzgajanoj na različitim terroirima. U okviru ovog projekta također se planiraju provesti predklinička i klinička istraživanja utjecaja ekstrakta lista masline na kandidijazu usne šupljine.]]></summary_hr><summary_en><![CDATA[Oleuropein and hydroxytyrosol are considered the main active olive compounds and their health benefits thought their anti-carcinogenic, anti-inflammatory, and antimicrobial proprieties has been proven. Nevertheless, oleuropein and hydroxytyrosol as well as total phenols, have specific role plant protection and resistance against fungal pathogens which may be of crucial importance for olive sustainable growing. It has been noticed that phenolic and polyphenolic compounds, as pre-formed antibiotic compounds, are ubiquitous in plants and play an important role in host plant’s pre-existing chemical defences against filamentous fungi. The phenolics in olive leaves, beside upgraded resistance to fungal pathogens, may have potential in the production of functional food and nutraceuticals. They could be easily used as oral remedies in the treatment of stomatognatic pathological conditions, where the need of finding new therapeutic procedures has led to increased interest in the use of natural substrates. There are evidence that agricultural practices can increase phenolics in olive leaves. Only a few studies have been focused on studying the effects of olive mineral nutrition on the olive leaves phenolic profile. In this project, series of experiments are planned to be conducted in order to determine the effect of selected mineral elements (N, Ca, Mg, Mn, Zn, Cu, and B) and elicitors (phosphite and potassium silicate) on leaf phenolic profile of olive cultivars. The effect of previously selected mineral/elicitor treatment as the best phenolic enhancer, on the development of olive leaf spot (Venturia oleaginea - syn. Spilocaea oleaginea), will be tested under greenhouse and field conditions. The impact of best phenolic enhancer will be tested thought quality of olive oil on Leccino cultivar grown at different terroirs. The preclinical and clinical studies investigating the effect of olive leaf extract on oral cavity candidiasis will be conducted during this project as well.]]></summary_en></project><project>
<id>6913</id><title_hr><![CDATA[Optimiranje depozicije raspršenih in situ gelirajućih i praškastih terapijskih sustava u nosnoj šupljini]]></title_hr><title_en><![CDATA[Optimisation of nasal deposition pattern of sprayable in situ gelling and powder drug delivery systems]]></title_en><user_id>5296</user_id><user_firstLast_name>Anita Hafner</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-4592</code><acronim><![CDATA[OptiNasalSpray]]></acronim><duration>01.01.2018 - 31.03.2023</duration><status>Završio</status><financ_value>237.839,27 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Farmacija, </scie_field_hr><scie_field_en>Pharmaceutical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Farmaceutsko-biokemijski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Pharmacy and Biochemistry]]></institution_en><team_members_id>6672, 22585, 24926, 855425, 858334, </team_members_id><team_members_names><![CDATA[Ivan Pepić, Ivo Ugrina, Laura Nižić, Cvijeta Jakobušić Brala, Mirna Perkušić, ]]></team_members_names><keywords_hr><![CDATA[Profil depozicije, profil raspršivanja, in situ geliranje, sušenje raspršivanjem, nazalna primjena, flutikazon, donepezil]]></keywords_hr><keywords_en><![CDATA[Deposition pattern, spray pattern, in situ gelling, spray drying, nasal delivery, fluticasone, donepezil]]></keywords_en><summary_hr><![CDATA[Nazalna primjena privlači značajnu pažnju svjetske znanstvene zajednice kao atraktivni put primjene lijekova sa lokalnim i sistemskim učinkom, te naročito neuroloških lijekova koji se mogu dostaviti direktno iz nosne šupljine u mozak. Anatomija i fiziologija nosne šupljine prepoznati su kao kritični faktori u razvoju terapijskih sustava, a posebice mukocilijarni mehanizam čišćenja koji ograničava vrijeme kontakta lijeka s nosnom sluznicom. Međutim, ključni parametar o kojem ovisi terapijski ishod nazalno primijenjenog lijeka je njegova depozicija unutar nosne šupljine.Cilj predloženog projekta je razviti terapijski sustav za nazalnu primjenu u obliku spreja, pažljivo dizajniranog profila depozicije i povoljnih biofarmaceutskih svojstava, a ovisno o ciljnom učinku lijeka. U istraživanju će se koristiti dva modelna lijeka, flutikazon – lijek s lokalnim učinkom koji treba doseći zonu polipa iza nosnih valvula, te donepezil- antidementik kojeg treba dostaviti u olfaktorno područje nosne šupljine kako bi se omogućila njegova direktna dostava u mozak. U izradi terapijskih sustava ispitat će se i usporediti primjenjivost dviju tehnologija s jednostavnim uvećanjem procesa: tehnologija in situ gelirajućih sustava i prašaka pripravljenih sušenjem raspršivanjem. Navedene tehnološke platforme omogućuju razvoj terapijskih sustava koji mogu produljiti vrijeme zadržavanja na mjestu depozicije te kontrolirati profil oslobađanja i apsorpcije lijeka.Nazalna depozicija ispitivat će se primjenom modela nosne šupljine uz simuliranje protoka zraka pri disanju. Fino ugađanje profila depozicije omogućit će se variranjem procesnih i formulacijskih parametara, uz primjenu različitih raspršivača i parametara primjene.Primjena statističkog dizajna eksperimenata omogućit će vrednovanje i razumijevanje utjecaja promatranih parametara na svojstva/profil depozicije in situ gelirajućih i praškastih sustava, te razvoj nazalnih pripravaka s ugrađenom kvalitetom uz uštedu uloženih sredstava i vremena.]]></summary_hr><summary_en><![CDATA[Nasal delivery receives much attention of the worldwide scientific community as an attractive route for drugs with local or systemic effect, and especially neurological drugs that can be delivered directly from the nasal cavity to the brain. The anatomy and physiology of the nasal cavity are recognized as the most critical factors in drug delivery system design, especially mucociliary clearance that limits the contact time between the drug and mucosa. However, the crucial parameter for the treatment outcome of nasally applied drug is its deposition within the nasal cavity. The purpose of the proposed project is to develop sprayable nasal delivery systems with carefully designed deposition pattern and favorable biopharmaceutical properties, in relation to targeted drug effect. Two model drugs will be used: fluticasone - a locally acting drug that needs to reach the polyp zone beyond the nasal valve, and donepezil - antidementic drug that needs to be deposited in the olfactory region within the nasal cavity to be directly transported to the brain.For the formulation development, applicability of two technologies that can be easily scaled up will be assessed and compared, namely, technology of in situ gelling systems and spray-dried powders. These technological platforms can be used to develop formulations able to prolong residence time at the deposition site and control drug release and absorption profiles.Nasal deposition will be studied using nasal cavity model simulating breath airflow. The deposition pattern will be fine-tuned by varying process and formulation parameters, in conjunction with different nasal devices and administration parameters.The usage of statistical Design of Experiments will enable the evaluation and elucidation of the influence of parameters employed on the characteristics/deposition pattern of developed drug delivery systems, potentiating the development of nasal formulations with built-in quality attributes in cost and time-saving manner.]]></summary_en></project><project>
<id>6917</id><title_hr><![CDATA[Razvoj, validacija i primjena analitičkih metoda za određivanje PBDE-a]]></title_hr><title_en><![CDATA[Development, validation and application of analytical methods for PBDE determination]]></title_en><user_id>1376</user_id><user_firstLast_name>Darija Klinčić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-6713</code><acronim><![CDATA[DeValApp]]></acronim><duration>01.10.2018 - 30.09.2023</duration><status>Završio</status><financ_value>189.063,64 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut za medicinska istraživanja i medicinu rada]]></institution_hr><institution_en><![CDATA[Institute for Medical Research and Occupational Health]]></institution_en><team_members_id>1490, 21444, 25491, </team_members_id><team_members_names><![CDATA[Marija Dvoršćak, Andreja Jurič, Karla Jagić, ]]></team_members_names><keywords_hr><![CDATA[polibromirani difenil eteri (PBDE), razvoj metode, mirkovalna ekstrakcija, GC-ECD, GC-MS, GC-MS/MS, kućna prašina, ljudsko mlijeko]]></keywords_hr><keywords_en><![CDATA[polybrominated diphenyl ethers (PBDEs), method development, microwave-assisted extraction (MAE), GC-ECD, GC-MS, GC-MS/MS, house dust, human milk]]></keywords_en><summary_hr><![CDATA[Svrha predloženog projekta je razvoj i validacija analitičkih metoda za određivanje specifičnih kongenera polibromiranih difenil etera (PBDE) u složenim uzorcima kućne prašine i ljudskog mlijeka. PBDE su široko rasprostranjeni u okolišu, akumuliraju se u hranidbenom lancu te dospijevaju u ljude na čije zdravlje mogu imati niz negativnih utjecaja. Kućna prašina prepoznata je kao važan izvor izloženosti ovim spojevima zbog njihove intenzivne uporabe kao usporivača gorenja u predmetima široko korištenim u svakom kućanstvu (namještaj, tekstil, električni i elektronski uređaji) dok je ljudsko mlijeko pouzdan bioindikator izloženosti ljudi ovim spojevima. Razvoj analitičkih metoda uključivat će ispitivanje i usporedbu različitih tehnika ekstrakcije analita iz uzorka pri čemu uz ekstrakciju na čvrstoj fazi i ultrazvučnu ekstrakciju posebno treba naglasiti primjenu dosad nekorištene metode, mikrovalne ekstrakcije. Ispitat će se načini i uvjeti pročišćavanja ekstrakta od interferirajućih spojeva i sastojaka matrice prije završne instrumentne analize. Odredit će se osjetljivost i selektivnost plinskokromatografskog određivanja PBDE-a uz detektore zahvata elektrona, spektrometar masa i spregnuti sustav tandemne spektrometrije masa. Validirane metode bit će provjerene analizom potvrđenih referencijskih uzoraka. Tijekom  projekta skupljat će se uzorci ljudskog mlijeka, a u domovima ispitanica paralelno će se uzorkovati i kućna prašina. Optimirane i validirane analitičke metode primijenit će se za analizu PBDE-a u skupljenim uzorcima. Dobiveni rezultati o razinama i raspodjeli PBDE-a bit će prvi takvi u Hrvatskoj i služit će za procjenu  važnosti unosa PBDE-a u organizam putem udisanja kućne prašine te izloženosti opće populacije PBDE-ima. Iz svega navedenog zaključit će se postoji li potencijalni rizik za zdravlje ljudi s posebnim naglaskom na osjetljive skupine dojilja, dojenčadi i male djece.]]></summary_hr><summary_en><![CDATA[The purpose of the proposed project is to develop and validate analytical methods for determining specific polybrominated diphenyl ether (PBDE) congeners in complex samples of house dust and human milk. PBDEs are widespread in the environment, they accumulate in the food chain and enter human organism where they can exert a number of negative impacts. House dust is recognized as an important source of exposure to PBDEs because of their intensive use as flame retardants in objects widely used in households (furniture, textiles, electrical and electronic devices). On the other hand, human milk is a reliable bioindicator of people&#39;s exposure to these compounds. The development of analytical methods will involve the examination and comparison of various types of extraction techniques, whereby along with the solid phase extraction and ultrasonic extraction, particular emphasis will be put on the application of an unused technique, microwave extraction. Techniques and conditions for the cleanup of the extract from the interfering compounds and matrix components before the final instrument analysis will be investigated. The sensitivity and selectivity of gas-chromatographic determination of PBDEs by electron capture detectors, mass spectrometer and coupled tandem mass spectrometry will be determined. Validated methods will be confirmed by analysis of certified reference samples. During the project, house dust will be sampled in the homes of milk donors. The optimized and validated analytical methods will be used for PBDE analysis in collected samples. Results on PBDE levels and distribution will be the first of a kind in Croatia and will be used to assess the importance of PBDE intake in the body by inhaling house dust and exposure of general population to PBDEs. From all of the above mentioned, it will be concluded whether there is a potential risk to human health with a special emphasis on sensitive population groups of nursing mothers, infants and young children.]]></summary_en></project><project>
<id>6925</id><title_hr><![CDATA[Razvoj naprednih analitičkih metoda za lijekove i biološki aktivne tvari u liječenju upalnih bolesti crijeva]]></title_hr><title_en><![CDATA[Development of sophisticated analytical methods for drugs and biologically active compounds in inflammatory bowel disease treatment]]></title_en><user_id>1301</user_id><user_firstLast_name>Ana Mornar Turk</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-3949</code><acronim><![CDATA[IBDAnalytics]]></acronim><duration>01.01.2018 - 31.03.2023</duration><status>Završio</status><financ_value>171.610,33 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Farmacija, Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Pharmaceutical sciences, Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Farmaceutsko-biokemijski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Pharmacy and Biochemistry]]></institution_en><team_members_id>13100, 25223, 29172, 25304, 865187, </team_members_id><team_members_names><![CDATA[Miranda Sertić, Mario-Livio Jeličić, Maja Friščić, Edvin Brusač, Jelena Kovačić, ]]></team_members_names><keywords_hr><![CDATA[upalne bolesti crijeva, kromatografija, masena spektrometrija, tehnike pripreme uzoraka, kontrola kvalitete lijekova, dodaci prehrani, biološki lijeko]]></keywords_hr><keywords_en><![CDATA[inflammatory bowel disease, chromatography, mass spectrometry, sample preparation, ADME, quality control, dietary supplements, biopharmaceuticals]]></keywords_en><summary_hr><![CDATA[Upalne bolesti crijeva (UBC) spadaju u skupinu upalnih bolesti kod kojih upalni proces zahvaća područje tankog i debelog crijeva. Odabir farmakoterapije ovisno o proširenosti  i smještenosti bolesti,  neželjenim popratnim pojavama i cijeni. Budući da smanjuju potrebu za koritikosteroidima, imunomodulatori su najčešće propisivani lijekovi u liječenju UBC. Liječenje s monoklonskim protutijelima omogućava liječenje visoko specifičnim i neposrednim mehanizmom djelovanja, ali visoka cijena utječe na učestalost primjene ove skupine lijekova.Budući da upalni procesi u crijevima narušavaju resorpciju vitamina i minerala, pacijentima se preporuča njihova suplementacija tijekom farmakoterapije. Štoviše, nedostatak folne kiseline povećava rizik razvoja tumora kod pacijenata oboljelih od UBC.Velik broj pacijenata smatra dodatke prehrani koje sadrže biljne ekstrakte sigurnim i prirodnim načinom liječenja. Stoga, velik broj pacijenata oboljelih od UBC koriste dodatke prehrani koji sadrže indijski tamjanovac, justiciju i kurkumu.Glavni cilj predloženog istraživanja je razviti nove instrumentalne analitičke metode za kontrolu kvalitete lijekova i dodataka prehrani koji se koriste u liječenju UBC.Kako bi se poboljšala suradljivost pacijenata predložit će se nove fiksne kombinacije imunosupresiva i folne kiseline. Razvit će se metode za ispitivanje farmakokinetike, kontrole kvalitete i terapeutskog praćenja koncentracije lijekova. Razvit će se i analitičke metode za određivanje aktivnih i toksičnih tvari u biljnim dodacima prehrani te će se metode primijeniti za procjenu kvalitete dodataka prehrani na hrvatskom tržištu. Konačno, razvit će se 2D-SE-RP-DAD tehnika za određivanje monoklonskih protutijela i njihovih onečišćenja u biološkim i biosličnim lijekovima.]]></summary_hr><summary_en><![CDATA[Inflammatory bowel disease (IBD) is a group of inflammatory conditions of the colon and small intestine. In IBD, treatment decision is dependent on the stage of the disease, laboratory findings and endoscopic examination. Choice of pharmacotherapy depends largely on the severity of disease, location, side effects and adverse events, as well as cost. Immunosuppressants are the most prescribed drug class in IBD treatment as steroid-sparing therapy. The treatment of IBD with monoclonal antibodies presents high specificity and directed mechanism of action, but the high cost still represents a barrier to be overcome. As the inflammatory process along the digestive tract disrupts resorption of vitamins and minerals, their additional supplementation is recommended with pharmacotherapy therapy. Moreover, low folate intake has been associated with tumor growth in IBD. The majority of the patients consider herbal dietary supplements are safe and natural way of healing. Many patients with IBD take supplements such as Indian frankincense, Justicia and Turmeric. The main objective of the proposed research is to develop new instrumental analytical methods that could be applied in quality control of medicinal products and dietary supplements used in treatment of IBD. A new fix-dose combination of two drugs an immunosuppressant and folic acid to improve patient&#39;s adherence to their prescribed treatment will be proposed. Methods for investigation of pharmacokinetic behaviour, quality control and therapeutic drug monitoring will be developed. Analytical methods for determination of active and toxic compounds of herbal dietary supplements will be developed. The proposed methods will be applied for evaluation of quality assurance for dietary supplements in Croatian marketplace. Finally, an advanced 2D-SE-RP-HPLC/DAD technique will be proposed and applied for determination of monoclonal antibodies and their impurities in biologic drugs and biosimilars.]]></summary_en></project><project>
<id>6926</id><title_hr><![CDATA[Transormacija robota u edukacijsko sredstvo]]></title_hr><title_en><![CDATA[Transforming robots into educational tool ]]></title_en><user_id>6592</user_id><user_firstLast_name>Ana Sović Kržić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-5917</code><acronim><![CDATA[TRES]]></acronim><duration>15.03.2018 - 14.03.2023</duration><status>Završio</status><financ_value>171.743,31 eur</financ_value><scie_area_hr>Tehničke znanosti, Društvene znanosti, </scie_area_hr><scie_area_en>Technological sciences, Social sciences, </scie_area_en><scie_field_hr>Temeljne tehničke znanosti, Elektrotehnika, Računarstvo, Obrazovne znanosti, </scie_field_hr><scie_field_en>Basic engineering sciences, Electrical engineering, Computer sciences, Educational sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>22784, 25376, 25956, 28856, 857307, 865176, </team_members_id><team_members_names><![CDATA[Kristina Cergol Kovačević, Liljana Pushkar, Petra Karabin, Ivana Storjak, Ivan Kunović, Valentina Gučec Gučec, ]]></team_members_names><keywords_hr><![CDATA[edukacijski robot, analitika učenja, obrada video signala, otkrivanje znanja u skupovima podataka, edukacijsko sredstvo, nastavni materijali]]></keywords_hr><keywords_en><![CDATA[educational robot, learning analytics, video processing, data mining, educational tool, learning materials]]></keywords_en><summary_hr><![CDATA[Današnji trend je korištenje velikog broja elektroničkih uređaja u razredu: pametne ploče, prezentacije, Internet, edukacijski roboti. Iz mnoštva uređaja i informacija, teško je odrediti pomažu li oni uopće u poučavanju. Mnoge aktivnosti se upravo svode na njihovo korištenje, a ne na iskorištavanje njihovih prednosti s ciljem poučavanja. Predloženi projekt će razviti metodologiju evaluacije korištenja edukacijskih robota u poučavanju osnovnoškolskih predmeta. Pri tome će se uzeti u obzir postignuta razina znanja, ali i zadovoljstvo učenika za vrijeme i nakon održanog sata. Dodatno, roboti će se koristiti za identifikaciju individualne strategije učenja svakog učenika. Na temelju razvijene metodologije i eksperimentalnih rezultata, napravit će se usporedna analiza edukacijskih robota koji postoje na tržištu. Kako bi se postigli ciljevi projekta koristit će se analitički podaci koje je moguće prikupiti iz samih robota i njihovih programskih okruženja za vrijeme njihove upotrebe. Razvit će se algoritmi obrade prikupljenih informacija, njihova analiza, evaluacija i vizualizacija. Predložit će se prototip sustava koji uključuje unaprijeđene edukacijske robote, individualnu strategiju učenja učenika i nastavne materijale, a sa ciljem postizanja maksimuma znanja i uz maksimalno ugodan proces učenja. Istraživači okupljeni u istraživačku grupu su iskusni u dizajniranju, programiranju i korištenju edukacijskih robota, u razvoju metodologije istraživanja, u radi s učenicima osnovnih škola, te u otkrivanju znanja u skupovima podataka i u razvoju metoda znanosti o podacima.]]></summary_hr><summary_en><![CDATA[Today&#39;s trend is to use a number of electronic devices during the class: smart boards, presentations, the Internet, educational robots. From a plenty of devices and information, it is difficult to determine do they help or not in teaching pupils. Many activities are just about how to use the devices, and not to exploit their strengths in the teaching process. Proposed project will develop methodology for evaluation of the usage of educational robots in teaching primary school subjects. The methodology will consider the level of knowledge as well as learners’ satisfaction during and after the lessons. Additionally, the robots will be used for identification of individual learning strategies. Based on the developed methodology and experimental results, comparison of the state-of-the-art educational robots will be made. To achieve the project goals, analytic data will be collected from the logs of the educational robots and their programming environments. Algorithms for processing of the collected data, their analysis, evaluation and visualization will be developed. Finally, a prototype of a system, that includes the improved educational robots, the individual learning strategies and teaching materials will be proposed. The aim of the prototype is to achieve the maximum of the knowledge through a satisfying learning process. Researchers gathered in the research group have experience in designing, programming and using educational robots, in developing research methodologies, in field work with pupils, and in data mining and data science methods.]]></summary_en></project><project>
<id>6927</id><title_hr><![CDATA[Filogeografija i evolucija triju ekološki divergentnih grupa amfi-jadranskih biljaka]]></title_hr><title_en><![CDATA[Phylogeography and evolution of three ecologically divergent amphi-Adriatic plant groups]]></title_en><user_id>13550</user_id><user_firstLast_name>Ivana Rešetnik</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-2882</code><acronim><![CDATA[AmphiAdriPlant]]></acronim><duration>01.03.2018 - 28.02.2024</duration><status>Završio</status><financ_value>231.465,26 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>22700, 28771, 25313, 17842, 11179, </team_members_id><team_members_names><![CDATA[Ivica Ljubičić, Marko  Doboš, Ana Terlević, Maja Mucko, Martina Temunovic, ]]></team_members_names><keywords_hr><![CDATA[filogeografija, glacijalni refugiji, amfi-jadranske biljke, modeliranje ekoloških niša, RADseq]]></keywords_hr><keywords_en><![CDATA[phylogeography, glacial refugia, amphi-Adriatic plants, habitat suitability models, RADseq]]></keywords_en><summary_hr><![CDATA[Jugoistočna Europa predstavlja jedan od glavnih centara europske bioraznolikosti, prvenstveno zahvaljujući činjenici da su Apeninski i Balkanski poluotok djelovali kao glavni glacijalni refugiji biljnih i životinjskih vrsta tijekom glacijalno-interglacijskih ciklusa u Kvartaru. U sklopu ovog projekta predlažemo komparativnu filogeografsku studiju koja kombinira tradicionalne (morfolgija i plastidne DNK sekvence) i nove pristupe, kao što su sekvenciranje slijedeće generacije (RADseq) i modeli povoljnosti staništa kako bi se istražiti evolucijski putevi i diversifikacija triju ekološki divergentnih biljnih skupina rasprostranjenih na Apeninskom i Balkanskom poluotoku. Prvo ćemo rekonstruirati pojedinačne filogeografije vrsta Aurinia leucadea, A. sinuata, Festuca bosniaca i Dianthus sylvestris grupe na Balkanu i Apeninima kako bismo otkrili detaljne obrasce genetske raznolikosti divergentnih linija. Drugo, identificirat ćemo morfološke varijacije u istraživanim skupinama i ispitati da li morfološka divergencija odgovara genetskoj raznolikosti i/ili trenutnoj taksonomiji. Treće, procijenit ćemo njihove ekološke niše kako bismo otkrili potencijalnu sadašnju i prošlu rasprostranjenost te ćemo istražiti odnose između genetskih i ekoloških razlika. Četvrto, ispitat ćemo prostornu i vremensku podudarnost između rekonstruiranih filogeografija i usporediti dobivene lokacije glacijalnih refugija kao i putanje postglacijalnih širenja. Važnost predloženog projekta leži u tri točke: 1) dobiveni RADseq podaci visoke razlučivosti omogućit će sveobuhvatno ispitivanje prirodnih varijacija u širokom prirodnom okruženju, 2) dobiveni rezultati predstavljat će izravan doprinos očuvanju i upravljanju prirodom, i 3) sinteza komparativne filogeografije i modeliranja povoljnosti staništa pridonijet će rješavanju intrigantnih pitanja koja su daleko izvan ispitivane skupine: kako je bioraznolikost na Balkanu i Apeninima nastala te koji su procesi bili uključeni u njezino stvaranje. ]]></summary_hr><summary_en><![CDATA[South-eastern Europe is one of the major European biodiversity hotspots largely due to the fact that Apennine and Balkan Peninsulas have acted as major glacial refugia of temperate species during the Quaternary glacial–interglacial cycles. Here we propose a comparative phylogeographic study that combines traditional (morphology and plastid DNA sequences) and brand new approaches taking advantage of next-generation sequencing (RADseq) and habitat suitability modelling in order to explore the evolutionary trajectories and diversification of three ecologically divergent plant groups distributed on Apennine and Balkan Peninsulas. First, we will reconstruct the individual phylogeographic histories of Aurinia leucadea, A. sinuata, Dianthus sylvestris group and Festuca bosniaca on Balkan and Apennine Peninsulas to reveal range-wide patterns of genetic diversity. Second, we will identify morphological variation in the study groups and examine if morphological divergence corresponds to genetic diversity and/or current taxonomy. Third, we will evaluate their ecological niches to obtain potential present and past distributions and to examine the relationship between genetic and environmental divergence. Fourth, we will examine spatial and temporal congruence among the reconstructed phylogeographies and compare inferred locations of glacial refugia and postglacial expansion routes. The power of the proposed study lies in three points: 1) the implementation of high-resolution RADseq data will provide comprehensive examination of natural variation within range-wide native environment, 2) the obtained results will present direct contribution to nature conservation and management, and 3) the synthesis of comparative phylogeography and habitat suitability modelling will yield a much broader basis to address questions of interest going far beyond the group investigated: how the biodiversity on the Balkans and Apennines arose and which processes were involved in its formation. ]]></summary_en></project><project>
<id>6935</id><title_hr><![CDATA[Stohastička stabilnost i teorija potencijala Markovljevih procesa]]></title_hr><title_en><![CDATA[Stochastic stability and potential theory of Markov processes]]></title_en><user_id>987</user_id><user_firstLast_name>Nikola Sandrić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-8958</code><acronim><![CDATA[SSPTMP]]></acronim><duration>01.05.2018 - 30.04.2023</duration><status>Završio</status><financ_value>44.827,13 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>635, 22576, 22575, </team_members_id><team_members_names><![CDATA[Vanja Wagner, Petra Lazić, Ivana Valentić, ]]></team_members_names><keywords_hr><![CDATA[cenzurirani Levyev proces, Harnackova nejednakost, homogenizacija, Markovljev proces, stohastička stabilnost, slučajna okolina, teorija potencijala]]></keywords_hr><keywords_en><![CDATA[censored Levy process, Harnack inequality, homogenization, Markov process, stochastic stability, random environment, potential theory ]]></keywords_en><summary_hr><![CDATA[Veliki broj fenomena koji se javljuju u prirodi i inženjerstvu uključuju određeni stupanj nedeterminističnosti u svojem ponašanju. Prikladan matematički alat u modeliranju takvih fenomena je teorija vjerojatnosti. Osnovna zadaća te teorije je razvoj različitih matematičkih koncepata koji omogućavaju predviđanje budućeg ponašanja fenomena kojeg proučavamo.Fokus istraživanja ovog projekta je klasa tzv. Markovljevih procesa. To su stohastički procesi karakterizirani odsustvom memorije. Zbog tog svojstva, primjenetih procesa su brojne, kako u teoriji tako i u praksi. Osim njihove primjene u drugim područjima znanosti i inženjerstva, oni su također usko povezani s nizom drugih grana matematike.U ovom projektu usredotočit ćemo se na dva osnovna problema u teoriji i primjenamaMarkovljevih procesa: (i) stohastičkoj stabilnosti te (ii) teoriji potencijala Markovljevih procesa. Obje predložene teme pripadaju klasičnom smjeru u analizi Markovljevih procesa i motivirane su trenutnim smjerom istraživanja u teoriji i primjenama stohastičkih procesa. Stohastički stabilni Markovljevi procesi prirodno se nameću kao matematički modeli niza fenomena koji se javljuju u prirodi i inženjerstvu, kao što su problemi vezani uz rast populacija i homogenizaciju heterogenih struktura. Teorija potencijala nastala je u sklopu matematičke fizike kao osnovni alat za proučavanje elektrostatičkih i gravitacijskih problema. Cilj ovog projekta je poboljšati i unaprijediti postojeće metode, modele i pristupe te razviti nove s ciljem boljeg razumijevanja prirode Markovljevih procesa kroz njihovu stohastičku stabilnost i potencijalna svojstva. U tu svrhu bit će kombinirani pristupi i alati iz različitih matematičkih disciplina, poput teorije vjerojatnosti i stohastičkih procesa, matematičke analize i teorije diferencijalnih jednadžbi.]]></summary_hr><summary_en><![CDATA[Many phenomena arising in nature and engineering are characterized by a certaindegree of randomness in their behaviour. A suitable mathematical tool in modelling such phenomena is probability theory. The main task of this theory is to develop various mathematical concepts which allow us to predict the future behaviour of the phenomenon we are studying.The focus of research of this project is the class of so-called Markov processes. These are stochastic processes characterized by the absence of memory. Due to this feature, applications of these processes are numerous, both in theory and applications. Besides their application in other areas of science and engineering, they are also closely related to a number of other branches of mathematics. In this project, we will focus on two fundamental problems in the theory and applications of Markov processes: (i) stochastic stability and (ii) potential theory of Markov processes. Both proposed topics belong to the classical direction in the analysis of Markov processes and are motivated by the current direction of research in the theory and applications of stochastic processes. Stochastically stable Markov processes naturally arise as mathematical models in a number of phenomena arising in nature and engineering, such as problems related to population dynamics and homogenization of heterogeneous structures. Potential theory originates from mathematical physics as a basic tool in studying electrostatic and gravitational problems. The goal of this project is to improve and advance existing methods, models and approaches and to develop new ones with aim of better understanding the nature of Markov processes through their stochastic stability and potential theoretical properties. For this purpose, approaches and tools from various mathematical disciplines, such as probability theory, theory of stochasticprocesses, mathematical analysis and theory of differential equations will becombined.]]></summary_en></project><project>
<id>6936</id><title_hr><![CDATA[Promjene sastava patogena i imunološkog odgovora tijekom širenja areala uspješnih invazivnih vrsta slatkovodnih rakova]]></title_hr><title_en><![CDATA[Changes in the pathogen composition and immune response during range expansion of successful crayfish invaders]]></title_en><user_id>19913</user_id><user_firstLast_name>Sandra Hudina</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-1720</code><acronim><![CDATA[STRIVE]]></acronim><duration>01.04.2018 - 30.09.2023</duration><status>Završio</status><financ_value>194.640,65 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>19735, 22737, 25151, </team_members_id><team_members_names><![CDATA[Maja Šrut, Silvija Černi, Paula Dragičević, ]]></team_members_names><keywords_hr><![CDATA[invazivne vrste, slatkovodni ekosustavi, širenje areala, imunološki odgovor, patogeni]]></keywords_hr><keywords_en><![CDATA[invasive species, freshwaters, range expansion, immune response, pathogens]]></keywords_en><summary_hr><![CDATA[Invazivne strane vrste (ISV) imaju negativan utjecaj na funkciju i usluge ekosustava diljem svijeta, te njihova predikcija i upravljanje predstavljaju globalni izazov. Brzo širenje je bitna odrednica invazivnog uspjeha dok patogeni mogu značajno mijenjati invazivni uspjeh jer utječu na ekologiju svojih domaćina. Tijekom širenja areala ulaganje u imunološki odgovor na frontama invazije vjerojatno će biti izmijenjeno zbog promijenjenog pritiska patogena i ekoloških procesa koji se javljaju tijekom širenja. Smanjena brojnost/raznolikost patogena i potencijalno manja stopa njihovog prijenosa pri niskim gustoćama domaćina mogla bi smanjiti potrebu za jakim imunološkim odgovorom. S druge strane, jedinke koje dolaze u novi okoliš potencijalno su izložene većem opsegu patogena što bi zahtijevalo pojačani imunološki odgovor. S obzirom da i smanjeni i pojačani imunološki odgovor može koristiti jedinkama na frontama invazije, nije očigledno koja od ovih tendencija će prevladati prilikom širenja areala. Predloženi projekt će ispitati ovu temu koristeći grupu uspješnih slatkovodnih ISV – deseteronožne rakove. Prvo ćemo usporediti raznolikost i zastupljenost mikrobnih zajednica i intenzitet imunološkog odgovora invazivne vrste signalnog raka (Pacifastacus leniusculus) iz središta i s fronti širenja u rijeci Korani. Zatim ćemo provesti opsežno laboratorijsko istraživanje koristeći partenogenetsku vrstu mramornog raka (Procambarus fallax f. virginalis) kako bismo identificirali učinke gustoće, imunološkog odgovora i prisutnosti patogena na rast i reprodukciju jedinki. Završno, temeljem prikupljenih podataka kvantificirati ćemo kompromise između energetskih ulaganja u imunološki odgovor naspram ulaganja u karakteristike životnog ciklusa bitnih za invazivni uspjeh koristeći dinamičko modeliranje energetskih budžeta. Ovakav sveobuhvatni okvir istraživanja omogućiti će procjenu uloge i posljedica promjena imunološkog odgovora u invazivnom uspjehu.]]></summary_hr><summary_en><![CDATA[Invasive species impair ecosystem function and services worldwide and prediction and management of successful invaders represents a global challenge. Rapid dispersal is an important determinant of invasion success. Pathogens may greatly impact invasion success since they influence host ecology/evolution. Due to altered pathogen pressures and ecological processes arising from dispersal, immune investment will likely be altered during range expansion. Lower pathogen prevalence and potentially lower transmission rates at low densities of available hosts at invasion fronts might reduce the need for strong immune response. On the other hand, in a novel environment individuals may experience a broader range of pathogens which would require increased immune investment. Since individuals at the invasion front could benefit from both elevated and decreased immune response, it is not immediately obvious which of these tendencies will prevail during range expansion. We will test these issues using a successful group of freshwater invaders – non-indigenous crayfish. Firstly, we will compare diversity and abundance of crayfish associated microbiota and the intensity of immune response in individuals of the invasive signal crayfish (Pacifastacus leniusculus) from the invasion core and invasion fronts in the Korana River, Croatia. Secondly, we will perform an extensive laboratory study using parthenogenetic marbled crayfish (Procambarus fallax f. virginalis) to identify the effects of population density, pathogen presence, and immune response on individual growth and reproduction. Based on this input, we aim to quantify potential energy allocation trade-offs between immune function and life-history traits promoting invasion success using dynamic energy budget modelling. This comprehensive framework will allow us to assess population-level consequences of immune response alterations and their role in invasion success of a species.]]></summary_en></project><project>
<id>6938</id><title_hr><![CDATA[Razvoj armiranobetonskih elemenata i sustava s otpadnim prahom automobilskih guma ]]></title_hr><title_en><![CDATA[Development of Reinforced Concrete Elements and Systems with Waste Tire Powder]]></title_en><user_id>4343</user_id><user_firstLast_name>Ivana Miličević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-7113</code><acronim><![CDATA[ReCoTiP]]></acronim><duration>01.01.2018 - 31.12.2022</duration><status>Završio</status><financ_value>240.516,96 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Građevinarstvo, Temeljne tehničke znanosti, </scie_field_hr><scie_field_en>Civil engineering, Basic engineering sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Građevinski i arhitektonski fakultet Osijek]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Civil Engineering and Architecture Osijek]]></institution_en><team_members_id>3043, 3049, 3081, 4092, 22571, 13426, 22521, 24514, 24511, </team_members_id><team_members_names><![CDATA[Tanja Kalman Šipoš, Marin Grubišić, Ivana Šandrk Nukić, Marijana Hadzima-Nyarko, Hugo Rodrigues, Naida Ademovic, Tihomir Dokšanović, Robert Bušić, Kristina  Strukar, ]]></team_members_names><keywords_hr><![CDATA[prašina reciklirane gume, samozbijajući beton, konstrukcijski elementi, potresna otpornost, a-b okvir]]></keywords_hr><keywords_en><![CDATA[tire powder,  self-compacting concrete, structural elements, seismic resistance, r-c frame]]></keywords_en><summary_hr><![CDATA[Glavni cilj ReCoTiP projekta je razvoj novog materijala, samozbijajućeg betona s otpadnim prahom automobilskih guma, primijenjenog u nosivim armirano-betonskim konstrukcijama poboljšane potresne otpornosti. Definirani cilj postići će se osnivanjem nove međunarodne istraživačke grupe mladih znanstvenika u svrhu ubrzanog procesa razvoja neovisnih istraživačkih karijera nakon stjecanja titule doktora znanosti. Nova istraživačka grupa, uz snažnu potporu organizacije, provest će znanstvena istraživanja te eksperimentalnim i numeričkim metodama dokazati postavljene hipoteze. Provest će se demonstracija primjene otpadnog praha i sitnih zrna recikliranih automobilskih guma u samozbijajućem betonu, izrada i ispitivanja konstrukcijskih elemenata (greda i stupova) jednakih mehaničkih i trajnosnih svojstava u usporedbi s običnim samozbijajućim betonom te razvoj novog tipa/vrste armirano-betonskog okvira poboljšane potresne otpornosti. ReCoTip projekt dodatno će ojačati znanstvene i organizacijske kapacitete kroz dvije obranjene doktorske disertacije, tri diplomska rada i provedenog jednog poslijedoktorskog usavršavanja. Ovime se jamči osiguranje provedbe strateških ciljeva organizacije kao što je razvoj karijera mladih istraživača i sudjelovanja na međunarodnim kompetitivnim pozivima za prijave projekata tijekom trajanja RecoTiP projekta. Doprinos ReCoTiP projekta razvoju znanosti bit će vidljiv kroz obranjene dvije doktorske disertacije, tri diplomska rada i provedeno poslijedoktorsko usavršavanje. Nakon završetka predloženog istraživanja na projektu ReCoTiP bit će definirane konkretne preporuke za upotrebu i primjenu praha i sitnih zrna recikliranih otpadnih automobilskih guma i ključni smjer daljnjeg područja istraživanja s obzirom na rezultate dobivene projektom.]]></summary_hr><summary_en><![CDATA[Main goal of the ReCoTip project is development of new material, selfocompacting concrete with waste tire powder,  used in load-bearing reinforced-concrete structures of the improved seismic resistance. Defined goal will be achieved by establishing the new international research group of young scientists in order to accelerate establishment of independent research careers after obtaining the PhD award. New research group will conduct scientific research via experimental and numerical methods to prove defined hypothesis with strong Organisation support. The demonstration of the use of recycled tire powder and fine particles will be carried out in the self-compacting concrete, production and testing of structural elements (beams and columns) with equal mechanic and durability properties in relation to normal self-compacting concrete, including the development of the reinforced-concrete frame with  improved earthquake resistance. ReCoTip project will further strengthen scientific and organisational capacity through the two defended PhD thesis, three master thesis and one postdoctoral specialization carried out. This guarantees strategic interest of the organisation for the successful development of the applicants&#39; career and participation in international competitive calls during ReCoTiP project implementation. Following the completion of the planned research within the project ReCoTiP, specific recommendations relating to the use and the utilization of the recycled car tire rubber powder and fine grains will be made and key direction defined for the further field of researching with regards to the results achieved by the project. ]]></summary_en></project><project>
<id>6939</id><title_hr><![CDATA[Multilinearna i nelinearna harmonijska analiza i primjene]]></title_hr><title_en><![CDATA[Multilinear and Nonlinear Harmonic Analysis and Applications]]></title_en><user_id>740</user_id><user_firstLast_name>Vjekoslav Kovač</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-4129</code><acronim><![CDATA[MUNHANAP]]></acronim><duration>01.03.2018 - 28.02.2023</duration><status>Završio</status><financ_value>65.790,70 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>22484, 999, 21452, 22516, 864932, 865261, </team_members_id><team_members_names><![CDATA[Jelena Rupčić, Kristina Ana Škreb, Mario Stipčić, Rudi Mrazović, Aleksandar Bulj, Bruno Predojević, ]]></team_members_names><keywords_hr><![CDATA[bilinearna Hilbertova transformacija, multilinearni množitelj, ergodičko usrednjenje, Szemerédijev teorem, nelinearna Fourierova analiza]]></keywords_hr><keywords_en><![CDATA[bilinear Hilbert transform, multilinear multiplier, ergodic average, Szemerédi theorem, nonlinear Fourier analysis]]></keywords_en><summary_hr><![CDATA[Predloženi znanstveni projekt pripada grani harmonijske analize, ali ga se može smatrati interdisciplinarnim unutar polja matematike, u smislu da naša grupa namjerava riješiti nekoliko otvorenih problema iz raznovrsnih matematičkih grana, poput ergodičke teorije, aditivne kombinatorike i same harmonijske/Fourierove analize. Naš pristup će svesti te probleme na odgovarajuće kvantitativne (multilinearne ili nelinearne) ocjene u harmonijskoj analizi, koje ćemo potom dokazati analitičkim tehnikama.Prvi dio našeg projekta proučava ocjene multilinearnih integralnih formi sa zapetljanom strukturom. Ovdje namjeravamo dokazati ocjene za singularne forme pridružene hipergrafovima i pojačati poznate ocjene za multilinearne i simpleks Hilbertove transformacije. U drugom dijelu projekta proučavamo kvantitativnu konvergenciju višestrukih ergodičkih usrednjenja. Glavni ciljevi su nam omeđivanje varijacije po normi tih usrednjenja obzirom na potencije jedne transformacije, odnosno obzirom na nekoliko komutirajućih transformacija te kontrola varijacije po normi/točkama kubičnih ergodičkih usrednjenja. Treći dio bavi se teoremima Szemerédijevog tipa za podskupove euklidskog prostora s pozitivnom gustoćom te jakom verzijom Littlewoodove slutnje, usputno dokazujući odgovarajući invezni teorem. Četvrti dio projekta proučava SU(1,1) model nelinearne Fourierove analize. Karakteriziramo konvergenciju lakunarnih SU(1,1) trigonometrijskih produkata po normi i g.s. te ispitujemo uniformnu ograničenost konstanti u nelinearnoj Hausdorff-Youngovoj nejednakosti.Dakle, cjelokupni smjer našeg istraživanja je jedinstveni spoj tema međusobno povezanih specifičnim tehnikama pristupa. Neka od pitanja na koja namjeravamo dati odgovor već su dosad opsežno popularizirana u postojećoj literaturi i dokazano su teška i zanimljiva.]]></summary_hr><summary_en><![CDATA[The proposed project falls into the realm of harmonic analysis, but it can be regarded as inter-disciplinary within the field of mathematics, in the sense that our group intends to solve several open problems from diverse branches of mathematics, such as ergodic theory, additive combinatorics, and the harmonic/Fourier analysis itself. Our approach will reduce those problems to the appropriate quantitative (multilinear or nonlinear) estimates in harmonic analysis, which will then be established using the analytical techniques.The first part of our project studies estimates for multilinear integral forms with entangled structure. Here we intend to prove estimates for singular forms associated with hypergraphs and improve the current estimates for the multilinear and simplex Hilbert transforms. In the second part of the project we investigate quantitative convergence of multiple ergodic averages. The main objectives are to bound the norm-variation of those averages with respect to powers of a single transformation or with respect to several commuting transformations, and to control the norm/pointwise-variation of cubic ergodic averages. The third part deals with the Szemerédi-type theorems for positive density subsets of the Euclidean space and with the strong version of Littlewood&#39;s conjecture, proving the corresponding inverse theorem along the way. The fourth part of the project studies the SU(1,1) model of the nonlinear Fourier analysis. We characterize the norm convergence and the a.e. convergence of the lacunary SU(1,1) trigonometric products and we investigate uniform boundedness of the constants in the nonlinear Hausdorff-Young inequality.Therefore, our research theme is a unique blend of the topics related by the specific techniques of approach. Some of the questions we intend to answer have already been popularized in the existing literature and they have proven to be difficult and interesting.]]></summary_en></project><project>
<id>6940</id><title_hr><![CDATA[Interakcije slatkovodnih patogenih oomiceta i okoliša]]></title_hr><title_en><![CDATA[Interactions of freshwater pathogenic oomycetes and their environment]]></title_en><user_id>18946</user_id><user_firstLast_name>Ana Bielen</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-6267</code><acronim><![CDATA[InteractOomyc]]></acronim><duration>01.02.2018 - 31.01.2023</duration><status>Završio</status><financ_value>248.431,39 eur</financ_value><scie_area_hr>Prirodne znanosti, Biotehničke znanosti, </scie_area_hr><scie_area_en>Natural sciences, Biotechnical sciences, </scie_area_en><scie_field_hr>Biologija, Biotehnologija, </scie_field_hr><scie_field_en>Biology, Biotechnology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Food Technology and Biotechnology]]></institution_en><team_members_id>1169, 11249, 25064, 25270, 11119, </team_members_id><team_members_names><![CDATA[Tomislav Vladušić, MAJA DENT, Dora Pavić, Anđela Miljanović, Marko Nuskol, ]]></team_members_names><keywords_hr><![CDATA[patogeni oomiceti, slatkovodni rakovi, slatkovodna akvakultura, mikrobne zajednice, ekološke interakcije]]></keywords_hr><keywords_en><![CDATA[pathogenic oomycetes, freshwater crayfish, freshwater aquaculture, microbial communities, ecological interactions]]></keywords_en><summary_hr><![CDATA[U posljednja dva desetljeća globalno širenje oomicetnih patogena u slatkovodnim ekosustavima uzrokuje smanjenje brojnosti mnogih populacija. Istovremeno, oomicetni patogeni uzrokuju značajne ekonomske gubitke u slatkovodnoj akvakulturi. Unatoč tome, većina postojećih istraživanja fokusirana je na odnos domaćina i uzročnika bolesti, dok se drugi tipovi ekoloških interakcija u koje su uključeni slatkovodni oomiceti uglavnom ne uzimaju u obzir. Stoga je osnovni cilj predloženog projekta poboljšati razumijevanje ekologije oomicetnih patogena u slatkovodnim ekosustavima. Kao modelni organizmi koristiti će se dva patogena oomiceta - Aphanomyces astaci i Saprolegnia sp. A. astaci je kao uzročnik račje kuge odgovoran za nestanak brojnih populacija zavičajnih deseteronožnih rakova u Europi i time je goruća tema u području konzervacije rakova. Oomiceti iz roda Saprolegnia uzročnici su saprolegnioze - bolesti pastrve i drugih salmonidnih riba značajnih za slatkovodnu akvakulturu u Hrvatskoj i svijetu. Primjenom interdisciplinarnog pristupa u kojem će se preklopiti moderne kemijske, molekularno-biološke, mikrobiološke i bioinformatičke metode, projekt će odgovoriti na nekoliko međunarodno relevantnih i do sada neistraženih pitanja. Istražit će se utjecaj abiotskih (sastav vode) i biotskih (sastav mikrobnih zajednica) čimbenika na različite faze životnog ciklusa oomiceta. Na taj će se način predvidjeti &#39;&#39;vruće točke&#39;&#39; koje imaju povećani rizik od širenja/izbijanja bolesti uzrokovanih oomicetima u slatkovodnim ekosustavima. Osim toga, istražiti će se potencijal komenzalnih bakterijskih zajednica domaćina za inhibiciju rasta oomiceta, kao i odabranih biljnih ekstrakata koji bi se mogli primijeniti kao mjera kontrole saprolegnioze u akvakulturi. Zaključno, rezultati predloženog projekta donijet će nova fundamentalna znanja o interakcijama oomicetnih patogena i njihovog okoliša te istražiti nove metode njihove kontrole.]]></summary_hr><summary_en><![CDATA[In the last two decades, global spreading of oomycete pathogens in freshwater ecosystems is causing decline of many populations. At the same time, oomycete pathogens are also causing significant economic losses in freshwater aquaculture. Despite of this, most of the existing research is focused on host/pathogen relationship, whereas other types of ecological interactions are largely overlooked. Therefore, the main objective of the proposed project is to improve understanding of the oomycete pathogens ecology in freshwater ecosystems. Two model oomycete pathogens will be used - Aphanomyces astaci and Saprolegnia sp. A. astaci is the causative agent of crayfish plague and is responsible for the disappearance of numerous indigenous decapod crayfish populations in Europe, which makes it a hot topic in the area of crayfish conservation. Oomycetes in the genus Saprolegnia are causing saprolegniosis – a disease of trouts and other salmonid fish important for freshwater aquaculture in Croatia and globally. Using an interdisciplinary approach with complementing methods in chemistry, molecular biology, microbiology and bioinformatics, the project will try to answer on several so far unexplored and internationaly relevant issues. The effect of abiotic (water composition) and biotic (microbial communities composition) factors on different oomycetal life cycle stages will be investigated. In that manner „hot spots“ in freshwater ecosystem will be predicted, having increased risk for outbreak/spreading of diseases caused by oomycete pathogens. In addition, the potential of hosts comensal bacterial communities and selected plant extracts to inhibit the growth of oomycetes will be investigated, as well as their potential application in controlling saprolegniosis in aquaculture. In summary, results of the proposed project will bring about new basic knowledge about oomycete pathogens interaction with their environment, and asses new methods for their control. ]]></summary_en></project><project>
<id>6948</id><title_hr><![CDATA[Fraktalna analiza diskretnih dinamičkih sustava]]></title_hr><title_en><![CDATA[Fractal analysis of discrete dynamical systems]]></title_en><user_id>2709</user_id><user_firstLast_name>Maja Resman</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-1020</code><acronim><![CDATA[DSfracta]]></acronim><duration>15.10.2018 - 14.10.2023</duration><status>Završio</status><financ_value>149.869,27 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>2932, 26243, </team_members_id><team_members_names><![CDATA[Goran Radunović, Dino Peran, ]]></team_members_names><keywords_hr><![CDATA[diskretni dinamički sustavi, klasifikacije fiksnih točaka, Dulacove klice, fraktalne zeta funkcije, teorija kompleksnih dimenzija]]></keywords_hr><keywords_en><![CDATA[discrete dynamical systems, classifications of fixed points, Dulac germs, fractal zeta functions, theory of complex dimensions]]></keywords_en><summary_hr><![CDATA[Cilj projekta je uspostava nove istraživačke grupe s novim smjerom istraživanja. Naglasak je na povezivanju dosadašnjih područja istraživanja članova tima: namjera nam je povezati kvalitativnu teoriju dinamičkih sustava i teoriju kompleksnih dimenzija fraktalnih skupova, kroz fraktalnu analizu orbita sustava. Pod pojmom fraktalnih svojstava orbita podrazumijevamo njihovu box dimenziju i generalizacije. Motivirani smo tzv. ‘inverznim pitanjem’: možemo li dobiti informaciju o ponašanju sustava fraktalnom analizom jedne jedine trajektorije sustava? Kompleksne dimenzije fraktalnog skupa generalizacije su njegove box dimenzije i preciznije otkrivaju geometrijsku strukturu skupa.  Analiza kompleksnih dimenzija orbita čini se dobro prilagođenom mjerenju složenosti sustava. Teorija kompleksnih dimenzija temelji se na analizi singulariteta kompleksnih funkcija (fraktalnih zeta funkcija koje je uveo Lapidus). To je samo po sebi zanimljivo područje, povezano sa spektralnom teorijom, matematičkom fizikom i teorijom brojeva (poznata Riemannova hipoteza). Namjera nam je primijeniti tu teoriju na važna pitanja u diskretnim dinamičkim sustavima, kao što je npr. klasifikacija sustava. Ukratko, ključne točke istraživanja su: klasifikacija (formalna ili analitička) 1-dimenzionalnih diskretnih sustava preko kompleksnih dimenzija njihovih orbita, te opisivanje bifurkacija sustava preko skupa kompleksnih dimenzija orbita. Cilj nam je i promicanje područja dinamičkih sustava u Hrvatskoj organiziranjem radionice i mini-kurseva. Planiramo proširiti i ojačati našu malu grupu zapošljavanjem novog doktoranda i poslijedoktoranda. U Hrvatskoj postoji samo mala, nedovoljno povezana grupa istraživača u području dinamičkih sustava, koju namjeravamo jače povezati. Tijekom provedbe projekta, poseban naglasak stavit ćemo na znanstveni razvoj doktoranda. Namjeravamo mu pružiti mogućnost međunarodne suradnje od samog početka karijere.]]></summary_hr><summary_en><![CDATA[The goal of the project is the formation of a new research group around a new research direction. It is meant as an interplay of areas of the team members: we plan to relate the qualitative theory of dynamical systems with the theory of complex dimensions of fractal sets, through fractal analysis of orbits. By fractal properties of orbits, we mean their box dimension and generalizations. We are motivated by the ‘inverse question’: can we extract information on the behavior of a system by fractal analysis of a single trajectory? The complex dimensions of fractal sets generalize the notion of their box dimension and reveal  the geometrical structure more precisely. Analysing complex dimensions of orbits seems to be well-adaptedto measuring the complexity of the system. The theory of complex dimensionsis based on the analysis of singularities of complex functions (fractal zeta functions introduced by Lapidus). It is a very interesting field in itself, related to spectral theory, mathematical physics and number theory (the well-known Riemann hypothesis).We plan to apply this theory to important questions in discrete dynamical systems, such as their classifications. In short, key points of the research are: classifications (formal and analytic) of 1-dim discrete systems through complex dimension analysis of attached orbits, and understanding their bifurcations by the set of complex dimensions of attached orbits. Our aim is also to promote the field of dynamical systems in Croatia by organizing a workshop and mini-courses. We plan to expand our small group by engaging a new PhD student and a postdoc. In Croatia, there is only a small group of researchers in dynamical systems, scattered in different areas, which we intend to bring closer together.  In the course of the project, we will put a particular effort in scientific growth of the new PhD student. We plan to provide her/him with the opportunity of international collaborations from the beginning of her/his career.]]></summary_en></project><project>
<id>6950</id><title_hr><![CDATA[Bolničke zaštitne tekstilije]]></title_hr><title_en><![CDATA[Hospital Protective Textiles]]></title_en><user_id>5211</user_id><user_firstLast_name>Sandra Flinčec Grgac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-8780</code><acronim><![CDATA[HPROTEX]]></acronim><duration>15.03.2018 - 14.09.2023</duration><status>Završio</status><financ_value>231.344,35 eur</financ_value><scie_area_hr>Tehničke znanosti, Biomedicina i zdravstvo, Biotehničke znanosti, </scie_area_hr><scie_area_en>Technological sciences, Biomedicine and health sciences, Biotechnical sciences, </scie_area_en><scie_field_hr>Tekstilna tehnologija, Farmacija, Biotehnologija, </scie_field_hr><scie_field_en>Textile technology, Pharmaceutical sciences, Biotechnology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Tekstilno-tehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Textile Technology]]></institution_en><team_members_id>3088, 4810, 4643, 2830, 22753, 22751, 19372, 3057, 22774, 25049, 26302, 865428, </team_members_id><team_members_names><![CDATA[Anita Tarbuk, Tihana Dekanić, Snježana Brnada, Ivana Kmetič, Jasna Jablan, Katia Grgić, Franka Žuvela Bošnjak, Teuta Murati, Marina Miletić, Rajna Malinar, Ivana Čorak, Ana Vrbić Vrbić, ]]></team_members_names><keywords_hr><![CDATA[generiranje tekstilne prašine, bolničke tekstilije, celulozne tkanine, kationiziranje, međupovršinske pojave, praćenje umrežavanja, postojane obrade]]></keywords_hr><keywords_en><![CDATA[textile dust generating, hospital textiles, cellulosic fabrics, cationization, interface phenomena, crosslinking monitoring,  durable  treatments]]></keywords_en><summary_hr><![CDATA[Glavni ciljevi projekta su uspostava interdisciplinarne istraživačke skupine, uključujući i mladog istraživača doktoranda, i Laboratorija za kontrolirano praćenje procesa umrežavanja, čime će se omogućiti sustavno istraživanje i prijenos znanja usmjerenih rješavanju problema pojave tekstilne prašine, potencijalnog prijenosnika zaraza i uzročnika kvarova uređaja u bolničkom okruženju. Proizvest će se tkanine od pređa iz pamuka (CO) i pamuk/poliestera (CO/PES) u svrhu istraživanja utjecaja konstrukcije pređe, veza i tkanine na generiranje tekstilne prašine prije i nakon provedenih ciklusa pranja. Razvijat će se i definirati uvjeti kationiziranja i antimikrobne dorade s kvarternim amonijevim spojevima, ß-ciklodekstrinima s inkapsuliranim antimikrobnim sredstvom i kitozanom u svrhu postizanja postojanosti na višestruke cikluse održavanja, a s ciljem minimalnog kemijskog i mehaničkog oštećenja što doprinosi manjem otpuštanju tekstilne prašine. Uspostavom Laboratorija detaljno će se istražiti sorpcija kupelji sa sredstvima za antimkrobnu obradu na tkanine primarno uzevši u obzir međupovršinska svojstva (DSA30S) i in situ praćenju utjecaja topline na fizikalno-kemijske promjene (FTIR-ATR GG) s ciljem preciznog definiranja sastava kupelji i procesnih parametra za postizanje postojanog umrežavanja. Promjene u CO i CO/PES tkaninama tijekom i nakon obrade, te višestrukih ciklusa održavanja, istražit će se na kristaliničnoj, fizikalno-kemijskoj i morfološkoj razini te analizom međupovršina primjenom FE-SEM, TGA, FTIR, XRD, MCC, GS-MS, EKA, SFE, CA, MMT, WRV, UV-VIS spektrofotometrijom. Novorazvijenim tkaninama ispitat će se toksičnost, te će se u skladu s dobivenim rezultatima predložiti njihova ciljana primjena u bolničkom okruženju uz prijedlog formulacije deterdženata i postupaka za njihovo održavanje. Pronalaženje i implementacija novih ideja bit će usmjerena prema poduzetništvu u svrhu poticanja gospodarskog rasta te daljnjim istraživanjima u okviru nove projektne prijave]]></summary_hr><summary_en><![CDATA[The project main goals are establishing of interdisciplinary research group, with young doctoral researcher, and Laboratory for Controlled Monitoring of the Crosslinking Process, enabling systematic research and knowledge transfer to solve the problem of generating textile dust, a disease carrier and instrument stoppage causer, in the hospital environment. The textile fabrics of cotton fibers (CO) and their polyester blends (CO/PES) will be produced. The influence of yarn, weave and fabric construction to the generating of textile dust before and after washing cycles will be researched. The conditions of cationization and antimicrobial finishing with quaternary ammonium compounds, ß-cyclodextrins with encapsulated antimicrobial agents, and chitosan will be developed to achieve permanency to textile care with minimizing chemical and mechanical damage, thereby contributing to a lower release of textile dust. By setting up a Laboratory, the fabric sorption of the bath with antimicrobial agents will be investigated through interfacial properties (DSA30S), and in situ heat-monitoring (FTIR-ATR GG) of physical-chemical change in fabric will be performed, in order to precisely define the bath composition and process parameters to achieve durable crosslinking. The change in CO and CO/PES during and after treatment, and after the textile care cycles, will be analyzed on crystalline, physico-chemical, morphological and interfacial level using FE-SEM, TGA, FTIR, XRD, MCC, GS-MS, EKA, SFE, CA, MMT, WRV, UV-VIS spectrophotometry. For the purpose of health and environment protection, all newly developed fabrics will be tested on toxicity and, according to the obtained results, their usage in the hospital environment with the proposal of detergent formulations and procedures for their care will be suggested. The finding and implementation of new ideas will be directed towards entrepreneurship with the aim of economic growth, and further research within new project application.]]></summary_en></project><project>
<id>6958</id><title_hr><![CDATA[Zelene tehnologije u sintezi heterocikličkih spojeva]]></title_hr><title_en><![CDATA[Green Technologies in Synthesis of Heterocyclic Compounds]]></title_en><user_id>11301</user_id><user_firstLast_name>Maja Molnar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-6593</code><acronim><![CDATA[GREENNESS]]></acronim><duration>01.01.2018 - 31.12.2022</duration><status>Završio</status><financ_value>190.382,74 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Prehrambena tehnologija, </scie_field_hr><scie_field_en>Food technology, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Prehrambeno-tehnološki fakultet]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Food Technology]]></institution_en><team_members_id>22632, 2735, 19387, 25728, 29593, </team_members_id><team_members_names><![CDATA[Mario Komar, Valentina Bušić, Melita Lončarić, Mirjana Prkačin, Martina Jakovljević, ]]></team_members_names><keywords_hr><![CDATA[eutektička otapala, zelena sinteza, kinazolinoni, Knoevenagelova kondenzacija, rodanin, piridin, 2,4-tiazolidindioni]]></keywords_hr><keywords_en><![CDATA[deep eutectic solvents, green synthesis, quinazolinone, Knoevenagel condensation, rhodanine, pyridine]]></keywords_en><summary_hr><![CDATA[Zelene metode sinteze u organskoj kemiji posljednjih godina postaju sve popularnije među znanstvenicima, koji ovim ekološki prihvatljivim načinom pokušavaju zamijeniti konvencionalne metode sinteze. Sinteza u eutektičkim otapalima, kao i sinteza uz pomoć mikrovalova su danas vrlo zastupljene u organskoj kemiji i mogu se okarakterizirati kao „zelene metode“ zbog malog utroška energije, kratkog reakcijskog vremena, upotrebi netoksičnih otapala, itd. Nadalje, eutektička otapala su netoksična i okolišno prihvatljiva otapala, lako se sintetiziraju iz biorazgradivih komponenti i pokazuju brojne prednosti u odnosu na konvencionalna organska otapala. Upravo zbog navedenih prednosti u odnosu na konvencionalne metode sinteze, osobito vezano za utjecaj na okoliš i ekološki aspekt, ove metode će se koristiti za sintezu nekih keterocikličkih spojeva na bazi kumarna, kinazolinona i piridina s potencijalnom biološkom aktivnošću.Glavni cilj ovog projekta je razviti ekološki prihvatljive metode sinteze važnih bioaktivnih heterocikličkih spojeva. Projekt će se uključivati 1) Sintezu derivata kinazolinona, 2) Knoevenagelovu kondenzaciju i 3) Sintezu derivata piridina, reakcije koje se svakodnevno provode u brojnim istraživačkim laboratorijima. Svakodnevno provođenje ovih reakcija konvencionalnim putem uzrok je povećanoj upotrebi, generiranju i odlaganju štetnih tvari, što ima golem negativan učinak na okoliš. Zelene metode u ovom slučaju su više nego dobrodošle. Stoga će se sve gore opisane reakcije optimirati i provesti u eutektičkim otapalima, uz miješanje i grijanje ili u kombinaciji s mikrovalovima i ultrazvukom. Na projektu će raditi dva doktoranda, u okviru svojih tema doktorskog rada, svaki na specifičnoj vrsti spojeva.]]></summary_hr><summary_en><![CDATA[Green methods in organic synthesis have been of interest for many chemists nowadays since there is a tendency of developing environmentally friendly and acceptable synthetic routes. Synthesis in deep eutectic solvents and microwave synthesis is often characterized as “green” due to their low energy consumption, short reaction times, use of non-toxic solvents, etc. Moreover, deep eutectic solvents are nontoxic and environmentally acceptable, easily synthesized from biodegradable components and show numerous advantages compared to conventional organic solvents. Therefore, due to their advantages compared to conventional synthesis, emphasising the environment safety and ecological issues, those methods will be employed in synthesis of some coumarin, quinazolinone and pyridine heterocyclic compounds with potential biological activity. The main goal of this project is to develop procedures for synthesis of various biologically active and important heterocycles using green technologies. This project will be performed considering three (3) aspects; 1) Synthesis of quinazolinone derivatives, 2) Knoevenagel condensation and 3) Synthesis of pyridine derivatives. All of these reactions are mostly performed conventionally and are very common in chemical laboratories, utilized in every day work of many researchers. Due to their daily performance, many toxic organic chemicals and solvents are spent, generated and disposed, causing an inormous impact on environment. Green technologies in this regard are more than welcomed. Therefore, all reactions described above will be optimized and performed in deep eutectic solvents, with stirring and heating, microwaves and ultrasound. Two doctoral students will be working on this project, each one of them dealing with specific type of compounds or reactions and it is expected that they gain their PhD diploma within this project. ]]></summary_en></project><project>
<id>6960</id><title_hr><![CDATA[Visokokvalitetna strojna tvorba govora za hrvatski jezik]]></title_hr><title_en><![CDATA[High-Quality Speech Synthesis for Croatian Language]]></title_en><user_id>4895</user_id><user_firstLast_name>Marin Vuković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-6917</code><acronim><![CDATA[HR-SYNTH]]></acronim><duration>01.05.2018 - 30.04.2023</duration><status>Završio</status><financ_value>125.033,61 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, Računarstvo, </scie_field_hr><scie_field_en>Electrical engineering, Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>5345, 25406, </team_members_id><team_members_names><![CDATA[Damjan Katušić, Renato Šoić, ]]></team_members_names><keywords_hr><![CDATA[strojna tvorba govora, sinteza govora, hrvatski jezik, primjena strojne tvorbe govora, generativni modeli]]></keywords_hr><keywords_en><![CDATA[speech synthesis, machine based speech synthesis, Croatian, speech synthesis applications, generative models]]></keywords_en><summary_hr><![CDATA[Strojna tvorba govora u informacijsko-komunikacijskoj tehnologiji prisutna je već dugi niz godina. Međutim, visokokvalitetna rješenja, koja su u mogućnosti savladati specifične i manje učestale jezične sintakse, su vrlo rijetka čak i za najzastupljenije svjetske jezike kao što su engleski i španjolski. Hrvatski je jezik, u kontekstu strojne tvorbe govora, vrlo složen i znatno složeniji od, primjerice, engleskog. Vjerojatno je i to jedan od razloga što za hrvatski jezik još ne postoji visokokvalitetna strojna tvorba govora. Promatrajući velike potencijale strojne tvorbe govora u mnogim područjima primjene, za koja postoje rješenja za najzastupljenije svjetske jezike, nameće se potreba za visokokvalitetnom strojnom tvorbom govora za hrvatski jezik. Kako bi se osigurala uspješna provedba predloženog projekta, osnovat će se istraživačka grupa sa zadaćama provedbe projekta, ostvarenja vidljivosti istraživačke grupe te diseminacijom znanja i rezultata projekta. Diseminacija rezultata je ključna za daljnje povezivanje s domenskim stručnjacima i istraživačima kako bi se osigurala održivost istraživanja te evolucija rješenja za strojnu tvorbu govora i nakon završetka predloženog projekta. Predloženi projekt ima više ciljeva, no prije svega je potrebno sustavno istražiti i evaluirati postojeće metode strojne tvorbe govora za sve jezike s naglaskom na jezicima sličnim hrvatskom jeziku. Na temelju istraživanja će se predložiti razvoj novih metoda koje bi mogle savladati specifičnosti hrvatskog jezika u kontekstu strojne tvorbe govora. Predložene metode će se implementirati u integrirano rješenje za strojnu tvorbu govora za hrvatski jezik u distribuiranoj i centraliziranoj okolini na odabranim područjima primjene. U konačnici, provest će se evaluacija razvijene strojne tvorbe govora kako bi se osiguralo visokokvalitetno rješenje koje će dugoročno moći zadovoljiti potrebe strojne tvorbe govora, evoluciju i primjenu na različitim područjima i nakon završetka predloženog projekta.]]></summary_hr><summary_en><![CDATA[Speech synthesis has been present in ICT domain for many years. However, high-quality solutions that can overcome specific and less common language syntax are rare, even for widespread languages such as English and Spanish. Croatian language is rather complex in the context of speech synthesis. Probably this is one of the reasons why there is still no high-quality speech synthesis for Croatian. When observing the great potential of speech synthesis in various application areas, which have several solutions for widespread languages, the need for Croatian speech synthesis becomes obvious. To ensure the successful implementation of the proposed project, a research group needs to be established with the tasks of project management, achieving visibility of the research group and dissemination of results of the project. Dissemination of project results is essential for further connecting with domain experts and researchers to ensure the sustainability of research and evolution of the proposed solution for speech synthesis, during and after the completion of the proposed project. The proposed project has several objectives, but above all it is first necessary to systematically analyse and evaluate existing methods of speech synthesis for all languages with an emphasis on languages like Croatian. The results of analysis and evaluation will help form a decision regarding implementation of new methods that could overcome the issues of Croatian language in the context of speech synthesis. The proposed methods will be implemented as an integrated solution for speech synthesis of the Croatian language in a distributed and centralised environment, on selected application areas. Finally, evaluation of the developed speech synthesis will be performed to ensure high-quality of the solution that will be able to meet the needs of speech synthesis in the long-term, as well as evolution and application in various fields during and after the completion of the proposed project.]]></summary_en></project><project>
<id>6962</id><title_hr><![CDATA[Modeli i inverzne metode za elektromagnetske senzore u bliskom polju]]></title_hr><title_en><![CDATA[Models and inverse methods for near field electromagnetic sensors]]></title_en><user_id>12596</user_id><user_firstLast_name>Darko Vasić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-6948</code><acronim><![CDATA[MIMES]]></acronim><duration>05.02.2018 - 04.07.2023</duration><status>Završio</status><financ_value>136.834,18 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, Računarstvo, </scie_field_hr><scie_field_en>Electrical engineering, Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>19300, 22790, 22765, 24508, 28628, </team_members_id><team_members_names><![CDATA[Davorin Ambruš, Robert Tutić, Matija Nestić, Dorijan Špikić, Ivan Rep, ]]></team_members_names><keywords_hr><![CDATA[senzori, elektronički sustavi, ugrađeni računalni sustav, inverzni problemi, elektromagnetski modeli, EM polje, blisko polje, nerazorno ispitivanje]]></keywords_hr><keywords_en><![CDATA[sensors, electronic systems, embedded systems, inverse problems, electromagnetic modelling, EM field, near field, nondestructive testing]]></keywords_en><summary_hr><![CDATA[Elektromagnetski senzori s radnim područjem u bliskom polju (eng. near field electromagnetic sensors, NFEMS) se temelje na promjenama električnog i magnetskog polja uslijed promjena u svojstvima materijala ili geometrije bliskih objekata ili procesa. NFEMS koji rade na frekvencijama do 10 MHz se mogu razvrstati prema dominantnom mehanizmu sprege na kapactivne (električna sprega) i induktivne (magnetska sprega). Aplikacije NFEMS-a su brojne zahvaljujući njihovoj neinvazivnosti, osjetljivosti, jednostavnosti i robusnosti. Uslijed rada u bliskom polju njihov najveći nedostatak je kompliciran odnos između mjerenih veličina (jakost polja, inducirani napon, impedancija) i ispitivanih svojstava (materijal, dimenzije, inkluzije i sl.). U pravilu, napredne primjene NFEMS-a zahtijevaju nepraktične računalno intenzivne inverzne procedure kako bi se dobio podatak pogodan za ljudsku upotrebu. Posljedično, aplikacije se oslanjaju na simplificirane modele za inverziju ili na ljudsku interpretaciju.Glavni cilj projekta je uspostava istraživačke grupe u području NFEMS-a uključujući senzorske tehnologije i sučelja, ugrađene računalne senzorske sustave, modeliranje i inverzne metode. U okviru projekta, istraživačka grupa će proučavati računalno efikasne modele NFEMS-a u području nerazornog ispitivanja cijevi i ispitivanja tla. Ova područja pokrivaju dva vrlo različita skupa materijala (vrlo vodljivi, magnetski i homogeni s inkluzijama, odnosno slabo vodljivi, dielektrični i heterogeni), pa će se istražiti različiti pristupi modeliranju te ekstrahirati zajedničke spoznaje. Istraživačka grupa će također proučavati inverzne metode zasnovane na razvijenim modelima te će eksperimentalno demonstrirati istraživane koncepte u dvije industrijski relevantne primjene. Radi ostvarivanja ciljeva projekta, grupa će razvijati napredna senzorska sučelja i ugrađene računalne sustave velike osjetljivosti, točnosti, raspoloživih računalnih resursa i sposobnosti za rad u otežanim uvjetima.]]></summary_hr><summary_en><![CDATA[Near field electromagnetic sensing (NFEMS) modality is based on the changes of electric and magnetic fields due to changes in material properties and geometry of nearby objects or processes. NFEMS operating below 10 MHz can be classified according to the dominant coupling as capacitive (electric coupling) and inductive (magnetic coupling) and they find their use in a vast number of sensing applications thanks to their non-intrusiveness, sensitivity, simple construction and robustness. Because of near field operation their greatest shortcoming is complicated relationships between measured quantities (field strength, induced voltage or impedance) and inspected properties (material properties, dimensions, inclusion, etc.). As a rule, advanced applications of NFEMS require impractical computationally-intensive inversion procedures to obtain human-suited information. Consequently, they rely either on simplified models for the inversion or on human interpretation.The overall objective of the project is to establish a research group in NFEMS including sensor technologies and interfaces, embedded sensor systems, modelling and inverse methods. During the project the group will study computationally efficient models for NFEMS in the domains of non-destructive testing of tubes and proximal soil sensing. These applications include two very different set of material properties (high conductive, magnetic, homogenous with small inclusions vs. low conductive, dielectric and heterogeneous) so different modelling approaches can be tested and complementary knowledge gained. The team will also study inverse methods based on the implemented models and will experimentally demonstrate the researched concepts on two industry-relevant applications. In order to accomplish the project&#39;s objectives, the group will engineer novel electromagnetic sensor interfaces and embedded systems with high performance in terms of sensitivity, accuracy, processing power and harsh environment deployment.]]></summary_en></project><project>
<id>6964</id><title_hr><![CDATA[Laboratorij za geoprostorne analize]]></title_hr><title_en><![CDATA[Geospatial analysis laboratory]]></title_en><user_id>12395</user_id><user_firstLast_name>Ante Šiljeg</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-2694</code><acronim><![CDATA[GAL / GAL]]></acronim><duration>06.03.2018 - 05.03.2023</duration><status>Završio</status><financ_value>181.228,88 eur</financ_value><scie_area_hr>Prirodne znanosti, Tehničke znanosti, Biotehničke znanosti, Humanističke znanosti, </scie_area_hr><scie_area_en>Natural sciences, Technological sciences, Biotechnical sciences, Humanities, </scie_area_en><scie_field_hr>Geografija, Geodezija, Poljoprivreda, Arheologija, </scie_field_hr><scie_field_en>Geography, Geodesy, Agriculture, Archeology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zadru]]></institution_hr><institution_en><![CDATA[University of Zadar]]></institution_en><team_members_id>22550, 22505, 19329, 22716, 21333, 3097, 25334, 865137, 22524, </team_members_id><team_members_names><![CDATA[Fran Domazetović, Ivan Marić, Vedrana Glavaš, Ivan Plaščak, Luka Babić, Nina Lončar, Mirko Barada, Lovre Panđa, Neda Kulenović, ]]></team_members_names><keywords_hr><![CDATA[daljinska istraživanja, GIS, LiDAR, morfometrijske analize, UAV, višekriterijske analize]]></keywords_hr><keywords_en><![CDATA[GIS, LiDAR, morphometric analysis, multi-criteria decision analysis, remote sensing, UAV]]></keywords_en><summary_hr><![CDATA[Osnovni  cilj projekta  je uspostava  Laboratorija  za geoprostorne analize  (GAL)  pri  Odjelu  za  geografiju  Sveučilišta  u  Zadru  te  okupljanje  interdisciplinarnog  tima  znanstvenika  iz  različitih  znanstvenih  polja (geografija,  arheologija, geodezija, agronomija). Osnovna  svrha GAL-a  je  provođenje  znanstvenih  istraživanja,  edukacija  mladih  istraživača, primjena novih znanja i tehnologija te razvoj  inovativnih metoda istraživanja. Prva faza uspostave usmjerena je na opremanje laboratorija s najsuvremenijim  uređajima  uz istovremeno usavršavanje istraživačkog  tima. Primjenom GIS-a u kombinaciji sa korištenjem tehnologije daljinskih istraživanja (bespilotna letjelica, 3D-skener, LiDAR, infracrvena kamera, termalna kamera itd.) omogućava se proučavanje određenog procesa  ili pojave u krupnom mjerilu, pri čemu su sve karakteristike promatranog objekta mjerljivo, odnosno kvantitativno opisane. Stoga je drugi cilj ovog projekta usmjeren na primjenu geoprostornih analiza u primijenjenim istraživanjima kroz  (a)  razvoj   višekriterijskog   modela  održivog  upravljanja   na  području  sedrotvornih vodotoka (b) razvijanje novog metodološkog pristupa u proučavanju  jaruga i (c)  pronalaženje  praktičnih  rješenja  kroz  primjenu  geoprostornih  analiza  u arheologiji i agronomiji. Ostvarenje navedenih ciljeva i izvedeni rezultati pokazali bi primjenjivost i opravdanost laboratorija u daljnjim znanstvenim istraživanjima. Jedinstveni doprinos ostvarenja ovog projekta očituje se u tome da bi GAL predstavljao prvi laboratorij za geoprostorne analize u RH koji će biti usmjeren na usavršavanje te promociju i edukaciju mladih znanstvenika kroz njihovo uključivanje u rad laboratorija. Znanstveni doprinos ovog istraživanja iskazati će se kroz pisanje dvije doktorske disertacije, čiji je osnovni cilj istraživanja izrada prvog plana održivog upravljanja sedrotvornim vodotocima te razvoj novog metodološkog koncepta za proučavanje jaruga. ]]></summary_hr><summary_en><![CDATA[The main aim of the project is to set up a Geospatial Analysis Laboratory (GAL) at the Department of Geography, University of Zadar, and to gather an interdisciplinary team of scientists from various fields (geography, archaeology, geodesy, agronomy). GAL&#39;s basic aim is to produce scientific research, educate young researchers, apply new knowledge and technology, and develop innovative research methods. The first phase of the application focuses on equipping the laboratory with the most up-to-date devices and accompanying software, while training the research team. The use of GIS in combination with RS technology (unmanned aerial vehicle, 3D scanner, LiDAR, infrared camera, thermal camera, etc.) facilitates the study of certain processes or phenomena at close range, while their characteristics are measurable, i.e. can be described quantitatively. Therefore, the second goal of the project focuses on the application of geospatial analyses in applied research through (a) the development of multicriteria models of sustainable management in the area of tufa-forming watercourses, (b) the development of a new methodical approach to studying gullies, and (c) discovering practical solutions through applying geospatial analyses in archaeology and agronomy. Achieving these goals and the results produced would demonstrate to applicability of and justification for GAL in further scientific research. The unique contribution of this project would be the creation of the first laboratory for geospatial analysis in Croatia, focusing on training, promoting and educating young scientists by engaging them in its work. The scientific contribution of this research will be seen in two doctoral dissertations, whose basic research topics are concerned with the production of the first plan for the sustainable management of tufa-forming watercourses, and the development of a new methodological concept for studying gullies. ]]></summary_en></project><project>
<id>6965</id><title_hr><![CDATA[Fotopobuđenja u 2D poluvodičima]]></title_hr><title_en><![CDATA[Photoexcitations in 2D semiconductors]]></title_en><user_id>6225</user_id><user_firstLast_name>Nataša  Vujičić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-3869</code><acronim><![CDATA[PhotoExcite(2)D]]></acronim><duration>01.03.2018 - 28.02.2023</duration><status>Završio</status><financ_value>201.101,60 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut za fiziku]]></institution_hr><institution_en><![CDATA[Institute of Physics in Zagreb]]></institution_en><team_members_id>19881, 22752, 22768, 28810, </team_members_id><team_members_names><![CDATA[Borna Pielić, Valentino Jadriško, Luca Moretti, Ana Senkić, ]]></team_members_names><keywords_hr><![CDATA[2D materijali, dihalkogenidi prijelaznih metala, ekscitoni, fotopobuda, vremenski razlučiva mjerenja, fotoluminiscencija, Raman spektroskopija]]></keywords_hr><keywords_en><![CDATA[2D materials, transition metal dichalcogenides, excitons, photoexcitations, time resolved measurements, photoluminescence, Raman spectroscopy]]></keywords_en><summary_hr><![CDATA[Glavni cilj ovog projektnog prijedloga je razvoj naprednih optičkih istraživanja dvodimenzionalnih (2D) poluvodičkih materijala poput dihalkogenida prijelaznih metala (TMDs) i njihovih iznimnih svojstava koja se ispoljavaju kao rezultat interakcije svjetlosti i materije. Ta interakcija, ne samo da otkriva elektronsku strukturu tih materijala, već može biti izniman način da se razumiju njihova strukturna svojstva. Iako je načinjen značajan pomak u istraživanju vlastitih ekscitonskih stanja monoslojeva (1L) TMDs, ta istraživanja se još uvijek intenzivno diskutiraju među teoretičarima, koji pak vape za eksperimentalnom potvrdom. Mjerenjem emisijskih spektara u različitim eksperimentalnim uvjetima, na sobnim i niskim temperaturama, izučavat ćemo elementarna pobuđenja u 2D poluvodičima koja su vrlo važna u fizici mnoštva čestica, koje je postalo vrlo atraktivno istraživačko područje upravo zbog toga što istražuje osnove kvantne mehanike.Još je jedan zaštitni znak 1L TMDs materijala, a to je tzv. vezanje spina i doline koje vodi do dolinski osjetljivih optičkih prijelaza između vrpci. Optičkom pobudom, uz pravilni odabir kiralnih pravila (uslijed narušavanja centralne simetrije), može se ostvariti obećavajuće svojstvo tih materijala za buduću primjenu u spintronici te valleytronici. Planiramo iskoristit našu mogućnost proizvodnje vertikalnih struktura iz 2D slojeva s ciljem utvrđivanja sistematične povezanosti između optičkog odziva i sastava slojeva u takvim materijalima te njihove međusobne orijentacije, primjenom čitavog niza inovativnih optičkih tehnika. Naš projekt će koristiti činjenicu da je na našem institutu razvijena tehnika sinteze uzoraka bazirana na depoziciji iz kemijskih para (CVD). Predloženi istraživački projekt i njegovi znanstveni ciljevi dobro se uklapaju u okvire međunarodno prepoznatljivog i relevantng znanstvenog rada, s odličnom perspektivom za uspjeh, ako imamo na umu njegovu uključenost u velike institutske projekte.]]></summary_hr><summary_en><![CDATA[The main goal of this proposal is advanced optical investigation of two-dimensional (2D) semiconductor materials such as transition metal dichalcogenides (TMDs) and their exceptional properties that emerge upon light-matter interaction. Not only that this interaction reveals electronic structure of such materials, but it can be an excellent tool for investigation of their structural properties. Though much progress has been made, intrinsic excitonic states of 1L TMDs are still highly debated in theory which craves for direct experimental determination. By measuring emission spectra in various experimental conditions in a controllable manner at both room and cryogenic temperatures we will explore elementary excitations in 2D semiconductors which are essential for many-body interactions study that become a very exciting research field for exploring fundamentals of quantum mechanics. Another trademark of monolayer (1L) TMDs is their valley-spin coupling which leads to a valley dependant helicity of interband optical transitions. Optical excitation using the chiral selection rules arising from 1L TMDs unique (a)symmetry is one route to obtain promising nanoscale systems for future spintronic and valleytronic applications. Our ability to vertically assemble 2D layers will be exploited with the aim to establish a systematic relationship between the optical response and heterostructure composition and stacking alignment between individual layers with innovative combination of various experimental techniques. Our project will benefit from the expertise in sample synthesis that has been established at the Institute based on controllable chemical vapor deposition (CVD) technique. Proposed research and its objectives fit well into the framework of internationally recognized and relevant scientific work, with the excellent perspective for success having in mind its involvement in major projects located at Institute of Physics.]]></summary_en></project><project>
<id>6968</id><title_hr><![CDATA[Klimatske promjene i varijabilnost u Hrvatskoj – od globalnih utjecaja do lokalnih zelenih rješenja]]></title_hr><title_en><![CDATA[Croatian climate variability and change – from global impacts to local green solutions]]></title_en><user_id>2650</user_id><user_firstLast_name>Ivana Herceg Bulić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-6396</code><acronim><![CDATA[CroClimGoGreen]]></acronim><duration>15.02.2018 - 15.08.2023</duration><status>Završio</status><financ_value>196.111,22 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Geofizika, </scie_field_hr><scie_field_en>Geophysics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>2635, 22511, 25094, 29394, 3137, 862800, </team_members_id><team_members_names><![CDATA[Melita Perčec Tadić, Irena Nimac, Sara Ivasić, Matej Žgela, Mladen Maradin, Marijana Boras, ]]></team_members_names><keywords_hr><![CDATA[urbani toplinski otok, klimatsko modeliranje, mjere ublažavanja, zelena i plava infrastruktura, Hrvatska]]></keywords_hr><keywords_en><![CDATA[urban heat island, climate modelling, mitigation measures, green and blue infrastructure, Croatia]]></keywords_en><summary_hr><![CDATA[Urbani razvoj bitno mijenja obilježja Zemljine površine i atmosfere te se pritom generiraju posebni klimatski uvjeti u urbanim sredinama - urbana klima. Nju karakterizira stvaranje urbanog toplinskog otoka (UHI, eng. Urban Heat Island), tj. bitno viša temperatura zraka u urbanom području u odnosu na okolno ruralno područje. UHI je značajan ekološki problem povezan s mnogim negativnim posljedicama (zagrijavanje podloge, nepovoljni klimatski uvjeti u gradu, povećan zdravstveni rizik, povećane potrebe za vodom, povećana potrošnja energije itd.). Projekt je usmjeren na proučavanje urbane klime, klimatske varijabilnosti i manifestacija klimatskih promjena u Hrvatskoj te njihovog utjecaja na urbani okoliš, a može se podijeliti na dvije povezane teme:   1) Klimatska obilježja urbanih sredina i klimatsko modeliranje: proučavanje obilježja urbanih sredina u Hrvatskoj i modeliranje potencijala za primjenu zelene i plave infrastrukture kao mjere ublažavanja učinaka UHI-a uz procjenu njihove učinkovitosti. Glavna namjera ovog dijela projekta je ispitati utjecaj različitih tipova vegetacije i otvorenih vodenih površina na urbani okoliš uzimajući u obzir njegov geografski položaj, lokalna klimatska obilježja i utjecaj okoline. Nadalje, istražit će se moguće buduće promjene karakteristika urbanog klimatskog otoka uz uvažavanje regionalnih klimatskih projekcija i pretpostavljenih promjena morfologije grada te učinkovitost mjera ublažavanja UHI-a u uvjetima toplije klime.2) Klimatska varijabilnost i klimatske promjene u Hrvatskoj će biti analizirane i u kontekstu utjecaja globalnih i regionalnih procesa. Ispitat će se mogući utjecaj globalnih modova klimatske varijabilnosti na klimatske ekstreme. Očekuje se da će ovaj dio projekta omogućiti istraživanje mogućeg sinergijskog međudjelovanja klimatske varijabilnosti velike skale i urbane mikro-klime.    ]]></summary_hr><summary_en><![CDATA[Urbanization brings many benefits for the society by improving the standards of living, but on the other hand, it is also associated with unwanted environmental, social and economic consequences. One such concern is Urban Heat Island (UHI), the phenomenon characterized by considerably higher air temperatures in urban areas as compared to the surrounding suburban and rural areas. UHI is a serious environmental problem associated with multiple negative consequences (overheating of the pavement surfaces, discomfort for citizens, increased health risk, increased water demand, increased consumption of energy etc.). Climate variability and manifestations of climate change in Croatia with potential impact on urban environment are in the focus of this project. The proposed project addresses to two main topics:1.) Urban climate in Croatia and climate modelling: examination of urban climate in different Croatian cities. Modelling approach is expected to enable analyses of the urban climate as well as to estimate the potential for integrating of green and blue infrastructure in urban environment as mitigation measures for reducing UHI effects. Impacts of different types of vegetation and open water surfaces on urban micro-climate will be considered. Also, possible future changes in UHI load will be examined taking into account regional climate projections and urban morphology.     2.) Croatian climate variability and change will be analysed in the context of influence of global and regional processes. The possible impact of climate variability and climate extremes related to, for example, global modes of climate variability and heat waves will be considered as well. It is expected that results obtained in this part of the project will provide analysis of possible synergistic interaction between large-scale climate variability and urban micro-climate.]]></summary_en></project><project>
<id>6969</id><title_hr><![CDATA[Formalno obrazovanje u funkciji održivog razvoja]]></title_hr><title_en><![CDATA[Formal Education In Service of Sustainable Development]]></title_en><user_id>2588</user_id><user_firstLast_name>Bojana Ćulum</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-2031</code><acronim><![CDATA[forOR]]></acronim><duration>03.01.2018 - 02.01.2024</duration><status>Završio</status><financ_value>144.077,24 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Pedagogija, Sociologija, </scie_field_hr><scie_field_en>Pedagogy, Sociology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Filozofski fakultet u Rijeci]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>3032, 923, 22758, 13384, 22714, 6892, 18914, </team_members_id><team_members_names><![CDATA[Nena Rončević, Siniša Kušić, Anja Gvozdanović, Branko Ančić, Nadja Čekolj, Nena Vukelić, Marija Brajdić Vuković, ]]></team_members_names><keywords_hr><![CDATA[održivi razvoj, građani održivosti, obrazovanje za održivi razvoj, kompetencije građana održivosti, obrazovanje građana održivosti]]></keywords_hr><keywords_en><![CDATA[sustainable development, sustainable citizens, sustainable citizenship, education for sustainable development, sustainable citizenship competencies]]></keywords_en><summary_hr><![CDATA[Ideja „održivosti“ prolazi kroz evolucijski put važnosti u kontekstu obrazovnih politika i praksi, a u literaturi se u posljednje dvije godine raspravlja o “građanima održivosti” i postupno se zamjenjuju poznati konstrukti ekološkog te društveno odgovornog i aktivnog građanstva. Prema UNESCO-vim smjernicama (2015, 2017), građanin održivosti razmišlja o utjecaju vlastita ponašanja na ekološki, društveni, politički i ekonomski aspekt svijeta oko sebe. Kritičan je prema vlastitom načinu življenja, a mora posjedovati kompetencije koje mu omogućuju kreativno, prilagodljivo i samoorganizirano djelovanje, razumijevanje kompleksnosti svijeta, suradnju, civilno zalaganje i djelovanje u smjeru ostvarivanja pozitivnih promjena u zajednici i društvu. Iako je obrazovanje za održivi razvoj uključeno u formalno obrazovanje, istraživanja upućuju na njegova ograničenja - postiže se pozitivan utjecaj na znanja učenika, ali ne i na njihove stavove i pro-aktivno ponašanje. O tome koliko formalno obrazovanje u Hrvatskoj doprinosi razvoju građana održivosti nema podataka pa ovaj projekt ima za cilj (I) identificirati odrednice, dominantna obilježja i zastupljenost građanstva održivosti u formalnom obrazovanju, (II) istražiti spremnost (budućih) učitelja i nastavnika za integraciju održivog razvoja u nastavu te izraditi njihovu tipologiju prema faktoru spremnosti na promjene. Rezultati istraživanja omogućiti će razvoj scenarija Obrazovanje za održivi razvoj u RH 2030. Primijenit će se multimetodološki pristup i provesti više empirijskih istraživanja o zastupljenosti i odrednicama građanstva održivosti na četiri populacije - (I) učenicima osnovnih i srednjih škola, (II) učiteljima i nastavnicima u osnovnim i srednjim školama, (III) studentima-budućim učiteljima i nastavnicima te (IV) nastavnicima u formalnom obrazovanju odraslih. Istraživanjem se doprinosi akademskoj i stručnoj raspravi u kontekstu stvaranja poticajnog okruženja za obrazovanje građana održivosti.]]></summary_hr><summary_en><![CDATA[The idea of sustainability has been going through an evolutionary path of importance in the context of educational policies and practices, while the construct of sustainable citizenship has been gradually replacing the well-known constructs of ecological and socially responsible and active citizenship. According to the UNESCO Guidelines (2015, 2017), the citizens of sustainability ponder the influence of their own behaviour regarding the ecological, social, political and economic aspects of the world. They are critical about their own way of life, and ought to possess the competencies which enable creative, adaptive and cooperative action by understanding the complexity of the world and civic engagement needed to foster positive changes. Although education for sustainable development is a part of the formal education, studies point to its limitations–it wields positive influence on students&#39; knowledge, but not on their attitudes and behaviour. There is no data on the extent to which formal education in Croatia contributes to the development of citizens of sustainability, so this project aims to (I) identify the determinants and representation of citizenship of sustainability in formal education, (II) explore competencies of (future) teachers needed to integrate sustainable development in their classes, and (III) make their typology according to their willingness to introduce changes in their teaching. Based on research results, a scenario for the Education for Sustainable Development in Croatia 2030 will be developed. A multi methodological approach with several empirical studies on the representation and the determinants of citizenship of sustainability will be implemented, targeting four populations-primary and secondary school students and teachers, student teachers, and teachers in formal adult education. The research will contribute to academic discussions on creating a stimulating environment for educating the citizens of sustainability.]]></summary_en></project><project>
<id>6971</id><title_hr><![CDATA[Jednozidne ugljikove nanocjevčice u eksperimentalnoj traumatskoj ozljedi mozga]]></title_hr><title_en><![CDATA[Single walled carbon nanotubes in experimental traumatic brain injury]]></title_en><user_id>19186</user_id><user_firstLast_name>Kristina Pilipovic</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-9517</code><acronim><![CDATA[CarNanoTBI]]></acronim><duration>01.09.2018 - 31.08.2023</duration><status>Završio</status><financ_value>228.946,84 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Medicine]]></institution_en><team_members_id>19848, 19752, 19750, 25435, 22656, </team_members_id><team_members_names><![CDATA[Tamara Janković, Petra Dolenec, Jelena Rajič, Nika Gržeta, Anja Harej, ]]></team_members_names><keywords_hr><![CDATA[astrociti, in vitro, in vivo, jednozidne ugljikove nanocjevčice, miš, traumatska ozljeda mozga]]></keywords_hr><keywords_en><![CDATA[astrocytes, in vitro, in vivo, mouse, single walled carbon nanotubes, traumatic brain injury]]></keywords_en><summary_hr><![CDATA[Traumatska ozljeda mozga (engl. traumatic brain injury, TBI) jedan je od vodećih uzroka invaliditeta i smrti u mladih osoba širom svijeta. Astrociti, najbrojnije i najraznolikije stanice u središnjem živčanom sustavu, snažni su regulatori održavanja homeostaze staničnog okoliša, a brojni dokazi upućuju na značajnu ulogu reaktivne astrocitoze u sinaptičkoj plastičnosti i reorganizaciji neuralnih krugova nakon TBI. Također, poznato je kako disfunkcija reaktivnih astrocita negativno utječe na ishode posljedično TBI-u. Iako su mnoge pretkliničke i kliničke studije doprinijele recentnim znanjima o patofoziologiji TBI, još uvijek postoje brojne nepoznanice zbog kojih ne postoji optimalno liječenje. Jedan od obećavajućih pristupa koji bi mogao omogućiti oporavak traumatski oštećenog mozga nakon TBI je tkivni inženjering, metoda koja je usmjerena na premoštenje strukturalnih defekata u moždanom tkivu. Ugljikove nanocjevčice (engl. carbon nanotubes, CNTs) imaju brojne izuzetne osobitosti poput veličine, čvrstoće, fleksibilnosti, vodljivosti i biokompatibilnosti koje ih čine obećavajućim materijalom za brojne biomedicinske aplikacije. S obzirom na gore navedeno, hipoteze ovog projekta jesu kako kemijski funkcionalizirane jednozidne CNTs potiču preživljenje i proliferaciju te utječu na funkcije astrocita podvrgnutih in vitro TBI, a kako nakon intracerebralne aplikacije u miša s traumom mozga potpomažu procese endogenog oporavka i regeneracije. Očekujemo kako će rezultati ovog projekta omogućiti bolje razumijevanje uloga astrocita u TBI te ukazati na moguću upotrebu gore spomenutog nanomaterijala u liječenju traume mozga.]]></summary_hr><summary_en><![CDATA[Traumatic brain injury (TBI) is one of the leading causes of disabilities and death in young adults worldwide. Astrocytes, the most abundant and diverse neuroglial cells in the central nervous system, are powerful regulators of the brain environment, and extensive evidence points to the significant role of reactive astrocytosis in post-TBI synaptic plasticity and the reorganization of neural circuits. However, it is also known that the dysfunction of the reactive astrocytes can contribute negatively to the TBI outcomes.  Even though many clinical and experimental studies have contributed to our knowledge regarding the pathophysiological basis of TBI, there are still many unknowns, and that is a major reason why there is still no optimal treatment. One of the promising approaches for the repair of the traumatically injured brain is the tissue engineering, a technique that focuses on the bridging of the structural gaps in the brain tissue. Carbon nanotubes (CNTs) possess many remarkable properties, such as the size, strength, flexibility, conductivity and biocompatibility, which make them a promising material for numerous biomedical applications. Based on the above mentioned, the hypotheses of this project are that chemically functionalized single walled CNTs improve the survival, the proliferation rate and affect the functions of astrocytes subjected to in vitro TBI and that their intracerebral application following brain trauma in mice provides support for the endogenous repair and regeneration processes. We expect that the results of this project will lead to better understanding of the roles of astrocytes in TBI and reveal the potential use of the aforementioned nanomaterial in the treatment of the brain trauma. ]]></summary_en></project><project>
<id>6972</id><title_hr><![CDATA[Epigenetički biomarkeri raka prostate]]></title_hr><title_en><![CDATA[Epigenetic Biomarkers in Prostate Cancer]]></title_en><user_id>3326</user_id><user_firstLast_name>Nino Sinčić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-8138</code><acronim><![CDATA[epiPro]]></acronim><duration>01.04.2018 - 31.03.2023</duration><status>Završio</status><financ_value>278.717,90 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Kliničke medicinske znanosti, Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Clinical sciences, Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>19967, 22587, 4711, 22582, 25378, 25176, 855381, 25371, </team_members_id><team_members_names><![CDATA[Monika Ulamec, Tomislav Kuliš, Stela Bulimbašić, Goran Štimac, Lucija Škara, Irena  Abramović, Ivan Pezelj, Dora Raos, ]]></team_members_names><keywords_hr><![CDATA[epigenetika, biomarkeri, rak prostate, metilacija DNA, miRNA, nsDNA, tekuće biopsije]]></keywords_hr><keywords_en><![CDATA[epigenetics, biomarkers, prostate cancer, DNA methylation, miRNA, cfDNA, liquid biopsies]]></keywords_en><summary_hr><![CDATA[Epigenetički poremećaji mogu se identificirati iznimno rano tijekom razvoja bolesti čovjeka. Stoga epigenetika snažno prodire u istraživanja biomarkera. Ipak, svijest o konkurentnosti epigenetičkih istraživanja sporo se razvija u hrvatskoj znanosti, što RH pozicionira na začelje europske znanosti u području. Namjera je ovog projekta podizati svijest o prednostima uvođenja epigenetičke problematike u uspostavljene istraživačke grupe, te educirati buduće mlade istraživače kao zalog budućih. Cilj je institucionalizirati grupu mladih istraživača koja će istraživati potencijalne epigenetičke biomarkere (EB) bolesti čovjeka (epiMark), odnosno identificirati EB raka prostate (RP) u okviru ovog projekta (epiPro). RP drugi je po učestalosti i treći uzrok smrti muškaraca od raka u RH. Naspram razvijenih zemalja, incidencija i mortalitet u RH stabilno rastu. Ipak, hrvatska znanost bilježi pad istraživanja RP što nas je pozicioniralo na začelje europskih zemalja gdje istraživanje EB RP predstavlja iznimno dinamično područje. Upravo EB, smatra se,  omogućit će između ostalog ranije postavljanje dijagnoze, osiguravajući i višu stopu preživljenja. Niz EB RP već je identificirano, ali ovo istraživanje prihvaća izazov najnovijeg koncepta u razvoju EB u okviru muškog reproduktivnog zdravlja – istraživanje EB sjemene tekućine, pored krvi. Hipoteza je predloženog istraživanja da se u sjemenoj tekućini, pored krvi, mogu identificirati EB RP. U okviru kliničke obrade, bit će uzeti anamnestički podaci te uzorci ejakulata i krvi pacijenata s RP i benignom hiperplazijom prostate. U sjemenoj tekućini i krvi, pirosekvenciranjem će se odrediti profili metilacije gena  na ne-staničnoj DNA, dočim qPCR-om ekspresija  miRNA, odabranih sukladno najnovijim spoznajama u literaturi. Epigenetičko i ekspresijsko profiliranje bit će provedeno i na uzorcima tumora istih pacijenata. Sveobuhvatnom statističkom analizom rezultata očekujemo identifikaciju EB RP.]]></summary_hr><summary_en><![CDATA[Epigenetic disorders can identified early during disease development. Therefore, epigenetics strongly penetrates into biomarker field. However, awareness of the competitiveness of epigenetic biomarker (EB) research is slowly developing in Croatia, which positions it at the margins of European science in the field. Intention of this project is to raise awareness of the benefits from addressing epigenetic issues into established groups and educate future young researchers as a pledge for future. The goal is to establish a new cohesive group of young researchers (epiMark) focused on investigating EB of human disease, as EB of prostate cancer (PC) within this very project (epiPro).CP is second in incidence and third cause of cancer deaths in Croatia. Contrary to developed countries, incidence and mortality in Croatia steadily rise. Nevertheless, Croatia records a fall in PC research, which has positioned us at the margins of European science where investigation of PC EB is an extremely dynamic field. Just as EB are considered, they will allow an earlier diagnosis ensuring patients a strong benefit. A line of PC EB has already been identified, but this research accepts the challenge of the latest concept in EB research within male reproductive health – a study of epigenetic BM in seminal fluid, beside blood. The hypothesis of the proposed study is that in the seminal fluid and blood, PC EB can be identified. In the frame of clinical processing of patient with PC and benign prostate hyperplasia, anamnestic data, samples of blood and seminal fluid will be taken. In seminal fluid and blood, profiles of gens DNA methylation within cfDNA will be identified by pyroseguencing, while expression of miRNA by qPCR. Genes and miRNA are selected according to recent findings. Epigenetic investigation and analysis of gene expression will be performed on patient cancer tissues as well. By comprehensible statistical analysis, we expect to identify potential CP EB from liquid biopsies.]]></summary_en></project><project>
<id>6973</id><title_hr><![CDATA[Otpornost stupova nadvožnjaka na djelovanje eksplozije ]]></title_hr><title_en><![CDATA[Blast Load Capacity of Highway Bridge Columns]]></title_en><user_id>4908</user_id><user_firstLast_name>Hrvoje Draganić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-7041</code><acronim><![CDATA[BLAST]]></acronim><duration>01.04.2018 - 30.09.2023</duration><status>Završio</status><financ_value>197.922,89 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Građevinarstvo, Temeljne tehničke znanosti, </scie_field_hr><scie_field_en>Civil engineering, Basic engineering sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Građevinski i arhitektonski fakultet Osijek]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Civil Engineering and Architecture Osijek]]></institution_en><team_members_id>3733, 12972, 4092, 22578, 25042, 1408, 3699, 2971, </team_members_id><team_members_names><![CDATA[Mario Jeleč, Ivan Radić, Marijana Hadzima-Nyarko, Adriana Cerovečki, Sanja Lukić, Ivan Kraus, Goran Gazić, Mario Galić, ]]></team_members_names><keywords_hr><![CDATA[stupište, eksplozije, ojačanje, numerički model, ispitivanje u stvarnom mjerilu]]></keywords_hr><keywords_en><![CDATA[column bent, blast load, strengthening, numerical model, full-scale experiment]]></keywords_en><summary_hr><![CDATA[Prometna infrastruktura postaje zanimljiv cilj terorističkih napada s obzirom da uništavanje određenih prometnih dionica ili konstrukcija, kao što su mostovi, može prouzročiti poteškoće u prometu i odsijecanje strateških točaka. Glavni cilj istraživačkog projekta je odrediti kapacitete na eksplozivna djelovanja za izgrađene mostove hrvatskih autocesta kroz određivanje najčešće korištenog tipa stupa mosta te štetu prouzročenu određenom količinom eksploziva postavljenom u automobilu smještenom ispod mosta. Prethodno istraživanje provedeno na stupovima zgrada je pokazalo da postoji veza između kapaciteta nosivosti na potresne sile i otpornosti na eksploziju. Sukladno tome, stupovi mosta će biti podijeljeni u dvije grupe, ispitani zasebno te uspoređeni s obzirom na otpornost na djelovanje eksplozija. Bit će ispitani u stvarnom mjerilu i to će biti prvo eksperimentalno istraživanje takvog tipa u svijetu. Ovo je važno budući da, bez obzira na korištene zakone skaliranja, nije moguće skalirati sve parametre koji su važni za ocjenu ponašanja stupa pri djelovanju eksplozija. Eksperimentalna istraživanja će biti provedena u suradnji s policijom koja će osigurati eksploziv i stručno osoblje za rukovanje eksplozivom. Količina eksploziva za ispitiivanje bit će određena kroz preliminarne analize na sustavima s jednim stupnjem slobode, temeljeno na pretpostavljenom stupnju ponašanja. Ovo će činiti bazu podataka mjerenih parametara uslijed djelovanja eksplozija, koja će biti korištena za kalibracije numeričkih modela. Cilj projekta je i razviti pouzdan i točan numerički model kojim će biti moguće numerički istražiti stup mosta koji nije eksperimentalno ispitan. Glavni rezultati projekta će biti: uspostavljena nova istraživačka grupa, izvršeno eksperimentalno istraživanje stupova u stvarnom mjerilu, baza otvorenog pristupa s mjerenim parametrima, točan i pouzdan numerički model stupa mosta, katalog oštećenja te prijedlog za ojačavanje i dimenzioniranje stupova mosta.]]></summary_hr><summary_en><![CDATA[Transportation infrastructure is becoming interesting target because damage or destruction of certain transportation routes or structures, as bridges, can cause disruption of traffic and cutting of strategic points. Main goal of this research project is to assess the blast load capacities of constructed bridges on Croatian highways by determining the most common type of bridge columns used and damage induced by charge detonation of certain amount of explosives by means of car deployment under the bridge. Previous research of building columns show that there is a relation between column seismic load capacity and column blast resistance. Based on this assumption, bridge columns will be separated into two groups investigated separately, and then compared for their blast resistance. Columns will be investigated in full-scale and this will be the first experimental investigation of this kind in the world. This is important because, no matter which scaling law is used, it is impossible to scale all parameters which are important for blast load assessment. Experimental investigation will be performed in cooperation with police which will provide explosives and trained personnel for explosive handling. Quantity of explosives for blast tests will be determined in preliminary single degree of freedom analysis of bridge columns based on performance levels assumed. This will make database of measured blast parameters which will be then used for numerical model calibration. Project goal is to develop reliable and accurate numerical model which will enable to numerically investigate bridge columns which are not experimentally tested. Main results of proposed project will be: establishment of a new research group, conducted experimental testing of full-scale bridge columns, open-access online database of measured blast parameters, accurate and reliable numerical model of bridge column, catalogue of sustained column damages and proposal for bridge column strengthening and design.]]></summary_en></project><project>
<id>6974</id><title_hr><![CDATA[Uloga urinarnih biomarkera u prekomjerno aktivnom mokraćnom mjehuru u djece]]></title_hr><title_en><![CDATA[Urinary biomarkers in overactive bladder in children]]></title_en><user_id>19974</user_id><user_firstLast_name>Slaven Abdović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-5379</code><acronim><![CDATA[pOAB]]></acronim><duration>01.01.2018 - 31.12.2022</duration><status>Završio</status><financ_value>149.885,33 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Kliničke medicinske znanosti, Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Clinical sciences, Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Klinika za dječje bolesti Zagreb]]></institution_hr><institution_en><![CDATA[Children's Hospital Zagreb]]></institution_en><team_members_id>22777, 25061, </team_members_id><team_members_names><![CDATA[Lorna Stemberger Marić, Merima Čolić, ]]></team_members_names><keywords_hr><![CDATA[Prekomjerno aktivni mokraćni mjehur, djeca, neurotrofini, NGF, urinarni biomarkeri, urodinamika]]></keywords_hr><keywords_en><![CDATA[Overactive bladder, children, neurotrophins, NGF, urinary biomarkers, urodynamics]]></keywords_en><summary_hr><![CDATA[Prekomjerno aktivni mokraćni mjehur (OAB) je najčešći funkcijski poremećaj donjeg urotrakta u djece i vodeći je uzrok intermitentne dnevne inkontinencije urina. Obligatorni simptom je hitnost, a hiperaktivnost detruzora je patognomonični urodinamski nalaz. Međutim, zbog invazivnosti urodinamike, dijagnoza se često postavlja samo na temelju simptoma. Pouzdana i neinvazivna dijagnostička metoda, kao i učinkovito liječenje, nužni su obzirom na visoku prevalenciju, značajan negativni utjecaj na kvalitetu života i nezanemarivo financijsko opterećenje. Patofiziologija bolesti temelji se na nesuspregnutim razinama neurotrofina u mjehuru, primarno NGF-a, što je potvrđeno na animalnim modelima i u kliničkim studijama. Kao učinkovito liječenje koriste se antikolinergici. Studije na odraslima pokazale su značajno više razine NGF-a u pacijenata s OAB-om koje su korelirale s težinom kliničke slike. Učinkovito liječenje dovodi do pada visokih razina urinarnog NGF-a, koje u refraktornim slučajevima perzistiraju. Refrakternost OAB-a je podržana kroničnom upalom mjehura što je potvrđeno visokom razinom urinarnih upalnih citokina. Potrebna su daljnja istraživanja kako bi se objasnila uloga urinarnih biomarkera, ne samo u patofiziologiji, već i kao učinkovite i neinvazivne dijagnostičke metode, što je osobito bitno u djece gdje se urodinamika, kao zlatni standard, većinom zaobilazi zbog nelagodnosti i nesuradnje djeteta. Ova studija je zamišljena kao prospektivna i intervencijska s ciljem ispitivanja varijabli koje značajno klinički koreliraju s produljenom primjenom antikolinergika (>6 mjeseci) i neučinkovitosti liječenja djece s OAB-om. Ispitane varijable će uključivati razine urinarnih neurotrofina i citokina, ultrazvučne biomarkere, simptome i znakove bolesti, demografske podatke i urodinamski nalaz. Sekundarni cilj je analizirati osjetljivost i specifičnost urinarnih biomarkera u dijagnostici i liječenju OAB-a u usporedbi s nalazom urodinamike i kliničkim mjerama ishoda. ]]></summary_hr><summary_en><![CDATA[Overactive bladder (OAB) is the most common bladder storage dysfunction in children and the primary cause of functional urinary incontinence. Urgency is the mandatory symptom, while detrusor overactivity is the urodynamic hallmark. Most of the time, the diagnosis is clinically based because of the invasiveness of the urodynamics. Reliable and noninvasive diagnosis, as well as effective management, are of great importance because of the high prevalence, significant negative impact on health-related quality of life, and substantial economic burden. Pathophysiology of OAB is based on uncontrollable high levels of urinary neurotrophins, primarily nerve growth factor (NGF), which was reported in animal experimental models and clinical trials. Anticholinergic therapy blocks neurotrophins pathway and is used as an effective treatment. Studies on adults have shown significantly higher NGF levels in patients with OAB which correlated to the severity of symptoms. Successful treatment resulted in significant decrease of NGF levels, while in refractory cases high urinary NGF persisted. In these patients, chronic bladder inflammation was implicated and was supported by high urinary inflammatory cytokines levels. Further research is needed to investigate the role of urinary biomarkers as a means of effective and noninvasive diagnosis, especially in children where invasive, gold standard for diagnosis of OAB, is mostly avoided. This study is planned as a single-center, prospective, single-arm trial. The aim is to investigate which variables are significantly correlated with prolonged anticholinergic treatment (>6 months) and nonresponse in children with OAB. Investigated variables will include urinary neurotrophins and inflammatory cytokines, sonographic biomarkers, symptom score, demographics, and urodynamic findings.  A secondary aim is to analyze sensitivity and specificity of urinary biomarkers in diagnosis and management of OAB compared to urodynamics and treatment outcomes.]]></summary_en></project><project>
<id>6976</id><title_hr><![CDATA[Primjena kakaove ljuske u proizvodnji čokolade i srodnih proizvoda]]></title_hr><title_en><![CDATA[Application of cocoa husk in production od chocolate and chocolate-like products]]></title_en><user_id>4578</user_id><user_firstLast_name>Đurđica Ačkar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-8709</code><acronim><![CDATA[COCOCHOCO]]></acronim><duration>02.01.2018 - 01.01.2023</duration><status>Završio</status><financ_value>162.756,27 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Prehrambena tehnologija, </scie_field_hr><scie_field_en>Food technology, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Prehrambeno-tehnološki fakultet]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Food Technology]]></institution_en><team_members_id>7262, 5709, 22708, 24554, </team_members_id><team_members_names><![CDATA[Ivana  Flanjak, Antun Jozinović, Kristina  Doko, Veronika Barišić, ]]></team_members_names><keywords_hr><![CDATA[kakaova ljuska, čokolada, kakao-proizvodi, polifenoli, vlakna, sigurnost hrane]]></keywords_hr><keywords_en><![CDATA[cocoa husk, chocolate, cocoa-products, polyphenols, fibre, food safety]]></keywords_en><summary_hr><![CDATA[Opći cilj projekta je uspostaviti istraživačku grupu za istraživanja u području tehnologije čokolade. Specifični cilj: primjena kakaove ljuske u obogaćivanju čokolade i srodnih proizvoda polifenolima i vlaknima te rješavanje problema njenog zbrinjavanja i utjecaja na okoliš. U tu svrhu pratit će se sastav i udio polifenola te udio prehrambenih vlakana u proizvodima. Kakaova ljuska teže se usitnjava od kotiledona pa će se primjenom hladne plazme pokušati riješiti taj problem.  Zbog velikog sadržaja vlakana u kakaovoj ljusci može doći do porasta viskoznosti proizvoda pa će se ispitati reološka svojstva i tekstura proizvoda i pokušati naći rješenje za njihovo optimiranje. Osim nutritivno vrijednih sastojaka, kakaova ljuska je i potencijalni izvor mikrobiološke kontaminacije, zbog visokog sadržaja proteina mogući je uzrok povećanog stvaranja akrilamida (AA) i hidroksimetilfurfurala (HMF), a masti u ljusci sadrže slobodne masne kiseline koje mogu smanjiti stabilnost proizvoda. Tijekom istraživanja i ovi će se aspekti uzeti u obzir. Očekivani rezultati su uspostavljena istraživačka grupa s kapacitetom za prijavljivanje novih projekata , izrađena 2 doktorska i 3 diplomska rada, 4 znanstvena rada pripremljena za objavu i čokoladna masa, krem-namaz i pripravak za instant napitak na bazi kakaa s definiranim udjelima polifenola, vlakana, svojstvima teksture i reološkim i senzorskim svojstvima. Nadalje, bit će definiran i utjecaj kakaove ljuske na sigurnost proizvoda – s utvrđenim udjelima AA i HMF-a te aerobnih mezofilnih i nekih patogenih bakterija, te plijesni i kvasaca. Rezultati istraživanja dat će izravan doprinos u širenju primjene hladne plazme sa dekontaminacije proizvoda na modifikaciju sirovina za proizvodnju hrane; omogućit će praktičnu primjenu kakaove ljuske u poboljšanju funkcionalnih svojstava čokolade i srodnih proizvoda, te dati uvid u nastanak nepoželjnih spojeva tijekom procesiranja (AA i HMF) i mikrobiološku ispravnost proizvoda s dodanom kakaovom ljuskom.]]></summary_hr><summary_en><![CDATA[The general objective of the proposed research is to establish research group for research on chocolate production. The specific goal is an application of cocoa husk in the enrichment of chocolate and similar products with polyphenols and fibre, solving its management since it has a large environmental impact. In that manner, polyphenol content and profile, and fibre content will be monitored in the products. Cocoa husk is coarser than nibs, so cold plasma will be used in an attempt to enhance its grinding. High fibre content in the husk can increase product viscosity, so its impact on rheological properties and texture of the products will be addressed and tried to be optimised.In addition to the high content of nutritionally valuable compounds, cocoa husk can be microbiological contamination source, its high protein content can cause an increase of acrylamide (AA) and hydroxymethylfurfural (HMF) formation, and fat in the husk contain free fatty acids that can decrease product stability. These problems will be considered in the research as well.Expected results are established research group with capacity to apply new projects in chocolate technology, showing it by application of the new project to a new funding source, 2 doctoral and 3 graduate theses, 4 scientific papers and chocolate mass, cream spread and instant cocoa-based beverage with defined contents of polyphenols, fibre, texture, rheology and sensory properties. Influence of the cocoa husk on food safety will be revealed as well – with revealed AA and HMF content, aerobic mesophyllic bacteria, several pathogenic bacteria and moulds and yeast content.The results will contribute to cold plasma application broadening to modification of food raw materials, it will aid practical application of cocoa husk to increase functional properties of chocolate and like products, and give insight into a synthesis of unwanted compounds during production and microbiological compliance of the products.]]></summary_en></project><project>
<id>6977</id><title_hr><![CDATA[Uloga Notch signalnog puta u patogenezi jetrene fibroze]]></title_hr><title_en><![CDATA[The Role of Notch Signalling Pathway in Pathogenesis of Hepatic Fibrosis]]></title_en><user_id>2631</user_id><user_firstLast_name>Tomislav Kelava</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-1965</code><acronim><![CDATA[NOFIBRO]]></acronim><duration>16.07.2018 - 01.05.2024</duration><status>Završio</status><financ_value>185.811,93 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, Clinical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>3133, 4149, </team_members_id><team_members_names><![CDATA[Petra Turčić, Anna Mrzljak, ]]></team_members_names><keywords_hr><![CDATA[fibroza jetre, Notch, alkoholna bolest jetre, praćenje sudbine stanica, transgenični model]]></keywords_hr><keywords_en><![CDATA[hepatic fibrosis, Notch, alcohol liver disease, fate mapping, transgenic mice]]></keywords_en><summary_hr><![CDATA[Osnovni cilj istraživanja je definirati ulogu Notch signalnog puta u patogenezi jetrene fibroze. U studiji ćemo koristiti animalni transgenični model u kojem se transgeničnim miševima Notch signalni put može selektivno potaknuti ili inhibirati u stanicama koje izražavaju alfaSMA primjenom tamoksifena .  Jetrena fibroza će biti inducirana primjenom CCL4 ili hranjenjem s DDC. U pojedinim pokusioma ćemo Notch inhibirati primjenom SAHM1 koji je specifičniji za NOtch od inhibitora korištenih u dosadašnjim studijama. Također, planiramo prikupljati I ljudske uzorke jetrenog tkiva cirotičnih I necirotičnih jetara I odrediti izražaj gena I proteina povezanih s Notch signalnim putovima, Iz uzoraka krvi, izdvojit će se DNA I određivati povezanost između odabranih Notch jednonukleotidnih genskih polimorfizama I jetrene fibroze tako što ćemo usporediti zastupljenoist polimorfizama u pacijenata sa cirozom jetre nastale zbog završnog stadija alkoholne bolesti  jetre koja zahtijeva liječenje transplantacijom sa zastupljenošću u kontrolnoj skupini.]]></summary_hr><summary_en><![CDATA[The main goal of project proposal is to define the role of Notch signaling in pathogenesis of hepatic fibrosis. To achieve this we will use animal transgenic mice model  in which Notch signalling can be activated or inhibited by tamoxifen injection selectively in alphaSMA expressing cells. To these mice hepatic fibrosis will be induced by CCL4 application and DDC feeding. In some experiments we will inhibit Notch pathway pharmaceutically by application of SAHM1 which is Notch specific in comparison with inhibitors used in previous studies.  We will also collect human samples from cirrhotic and noncirrhotic liver tissue and assess expression of Notch related genes and proteins. From blood samples DNA will be extracted to assess association between the selected Notch pathway single nucleotide polymorphisms and hepatic fibrosis by comparing their prevalence in general population with one in patients with end-stage liver disease due to alcoholic cirrhosis which require liver transplantation.]]></summary_en></project><project>
<id>6982</id><title_hr><![CDATA[Erozija i degradacija tala Hrvatske]]></title_hr><title_en><![CDATA[Soil erosion and degradation in Croatia]]></title_en><user_id>20011</user_id><user_firstLast_name>Igor Bogunović Bogunović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-7834</code><acronim><![CDATA[SEDCRO]]></acronim><duration>01.04.2018 - 31.03.2023</duration><status>Završio</status><financ_value>263.401,69 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Agronomski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Agriculture]]></institution_en><team_members_id>22749, 19017, 20377, 25053, 25711, 855969, </team_members_id><team_members_names><![CDATA[Paulo Pereira, Aleksandra Perčin, Ivana Šestak, Leon Josip Telak, Iva  Hrelja, Ivan Dugan, ]]></team_members_names><keywords_hr><![CDATA[erozija tla vodom, degradacija tala, vinogradi, klimatske promjene, voćnjaci]]></keywords_hr><keywords_en><![CDATA[soil water erosion, soil degradation, vineyards, climate changes, orchards]]></keywords_en><summary_hr><![CDATA[Degradacija tla je glavni okolišni problem u svijetu i ključno je da takvi procesi budu ublaženi. Potreba da se smanji utjecaj poljoprivrednih aktivnosti na okoliš i kontrolira degradacija strukture tala je jedan od glavnih ciljeva gospodarenja tlima. Različite strategije su razvijene radi smanjenja najvažnijeg degradacijskog problema – erozije tla. Međutim, poljoprivreda je još uvijek izvor najviše sedimenata u površinskim otjecajnim vodama. Danas, mnoštvo razloga pokreće neprihvatljivo gospodarenje tlima na poljoprivrednim tlima RH. Usprkos važnosti teme istraživanja o degradaciji tala na poljoprivrednim tlima u RH nedostaju. Mehanizmi, procesi, proporcije i kontrola erozije tla bili su istraživani u „Zapadnim“ državama više od stoljeća, ali je nadopuna potrebna radi prenošenja novih saznanja i rasprave o novim izazovima. U RH takva istraživanja nedostaju što otvara mnoga pitanja tijekom svakodnevnih klimatskih ekstrema. Klimatske promjene povećavaju broj olujnih kiša. Takve oluje su uzrok netolerantnih erozijskih nanosa s razarajućim posljedicama po okoliš. Istraživanje erozije i degradacije tla na tlima u RH mogu pružiti detaljan uvid za razumijevanje procesa degradacije tala. Trenutna tema istraživanja može otkriti najugroženija tla i najlošije načine korištenja istih. Glavni faktori koji određuju gubitak tla erozijom i površinskim otjecanjem biti će ocjenjeni.Ovaj projekt predlaže kompletni pregled tla, korištenja zemljišta u drugačijim klimatskim uvjetima u Hrvatskoj koji se bave problemom erozije tla vodom. Baza podataka iz 5-godišnjeg istraživanja (s više od 40 lokacija) biti će jedan od najkompletnijih aktualnih baza za proučavanje utjecaja uzročnih čimbenika na eroziju tla vodom. ]]></summary_hr><summary_en><![CDATA[Soil degradation is a major environmental problem worldwide and is crucial that such processes must be mitigated. The need to reduce the environmental impact of agricultural activities and to control soil structure degradation is one of the main aims of land management. Strategies have been developed to reduce the most important degradation problem- soil erosion. However, agriculture is still the source of most sediments in surface runoff waters. Nowadays, complex of reasons are driving forces for unsustainable soil management practices in Croatian agricultural land. Despite the relevance of the topic there is lack of research on soil degradation on Croatian agricultural soils. The mechanisms, processes, rates and control of soil erosion have been scientifically studied in Western countries, but an update was needed to convey new findings and discuss new challenges. In Croatia, such research is missing which especially open the new dilemma during every-day climatic extremes. Climate changes increase a numbers of high rainfall intensity events. Such events triggered intolerant soil erosion rates with devastating consequences to environment.Research of soil erosion and degradation on Croatian soils can provide deep insight for understanding the processes of soil degradation. Present subject can help to discover most endanger soils and unsustainable land use practices. This project will quantify water and soil losses in Croatian agricultural soils under high intensity rainfall simulation on the soils under several land use and management strategies. The main factors that determine soil losses and runoff will be assessed.This project proposed an overview of soils, land use, and climatic conditions in Croatia that deal with the problem of soil water erosion. Dataset derived from 5 years research (from more than 40 locations) will be one of the most complete and up to-date databases for studying the effect of triggering factors on soil water erosion. ]]></summary_en></project><project>
<id>6984</id><title_hr><![CDATA[ALTERNATIVNA VEZIVA ZA BETON: razumijevanje mikrostrukture za predviđanje trajnosti]]></title_hr><title_en><![CDATA[ALTERNATIVE BINDERS FOR CONCRETE: understanding microstructure to predict durability]]></title_en><user_id>3398</user_id><user_firstLast_name>Marijana Serdar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-4767</code><acronim><![CDATA[ABC]]></acronim><duration>01.04.2019 - 31.07.2024</duration><status>Završio</status><financ_value>285.020,83 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Građevinarstvo, Temeljne tehničke znanosti, </scie_field_hr><scie_field_en>Civil engineering, Basic engineering sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Građevinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Civil Engineering]]></institution_en><team_members_id>1276, 17806, 855345, 856242, 856244, 856247, 863810, 863808, 863809, 866632, 17771, 867584, </team_members_id><team_members_names><![CDATA[Ivan Gabrijel, Martina Pezer, Ivana Vladić Kancir, Matea Flegar, Kiran Ram Porikam Poil Poil, Antonino Runci Runci, Alma-Dina Bašić, Josipa Skočibušić Pejić, Marko Rukavina, Olivera Bukvić, Vanja Gilja, Valentina Mustapić, ]]></team_members_names><keywords_hr><![CDATA[alternativna veziva, održivost, mikrostruktura, trajnost, napredni instrumenti]]></keywords_hr><keywords_en><![CDATA[alternative binders, sustainability, microstructure, durability, advance techniques]]></keywords_en><summary_hr><![CDATA[Ukupna proizvodnja cementa u 2015. godini iznosila je 4,6 milijarde tona, što iznosi oko 626 kg cementa po stanovniku, količina veća od ukupne potrošnje hrane po stanovniku. Ako građevinska industrija nastavi s &#39;&#39;poslovanjem kao i obično&#39;&#39;, s obzirom na očekivani brzi rast populacije i predviđenu povećanu proizvodnju, u 2050. godini samo proizvodnja cementa će doprinijeti oko 24% ukupne globalne emisije CO2. Kako bi se istovremeno zadovoljila potreba ljudi za urbanizacijom i europski ciljevi zaštite prirodnih resursa i smanjenja emisija, postoji snažna motivacija za razvoj održivih građevinskih rješenja s manjim utjecajem na okoliš, sukladnih sedmom osnovnom zahtjevu za građevinske radove - održivom korištenju prirodnih resursa.Alternativni veziva za beton (ABC) predstavljaju novu generaciju građevinskih materijala, temeljenih na industrijskom otpadu i dosada neiskorištenim materijalima, koji su održiva i ekonomska alternativa klasičnom Portland cementu. Da bi se postigla gotovo potpuna zamjena cementa, od najveće je važnosti koristiti temeljnije pristupe istraživanju alternativnih veziva, omogućujući razumijevanje materijala na više razina (nano-mikro-makro). Istodobno, kako bi se osigurala upotreba ovih alternativnih materijala u praksi, potrebno je koristiti napredne analitičke instrumentalne metode i pouzdane modele za procjenu životnog vijeka kao odgovor na pitanja koja se tiču dugoročne trajnosti ABC u agresivnom okolišu.Ciljevi projekta su: osnivanje istraživačke skupine kao centra izvrsnosti za istraživanja, razumijevanje i korelaciju mikrostrukture i trajnosti alternativnih veziva za beton; osposobljavanje za samostalno korištenje naprednih analitičkih instrumentalnih metoda, koje pruža regionalna mreža instrumentarija; te obučavanje od strane međunarodnih centara znanja i izvrsnosti u specifičnom istraživačkom području. Nakon projekta ABC istraživačka skupina će biti održiva kroz konkurentno sudjelovanje u europskom istraživačkom prostoru.]]></summary_hr><summary_en><![CDATA[In 2015, the total mass of cement produced was 4,6 billion tonnes, which is equivalent to about 626 kg of cement/per capita, a value higher than the amount of human food consumption. If construction industry continues with “business as usual”, considering the expected rapid population growth and predicted production increase, in 2050 cement industry alone will contribute to 24% of total global CO2 emission. To meet the people’s need for urbanisation and at the same time satisfy European goals for protection of natural resources and lowering emissions, there is a strong motivation to develop more sustainable construction solutions with a lower environmental impact and in line with 7th basic requirement for construction works - sustainable use of natural resources.Alternative binders for concrete (ABC) present a new generation of construction materials, based on industrial waste and abundant materials, that are sustainable and economic alternative to ordinary Portland cement. To be able to reach high or total cement replacement, it is of paramount importance to use more fundamental approaches to research of alternative binders, enabling understanding across several scales (nano-micro-macro). At the same time, to secure their use in practice, it is necessary to use advance analytical tools and reliable service life models to answer the questions concerning long term durability of ABC in aggressive environments.The aim of the project is to establish research group as a centre of expertise for multiscale research, understanding and correlation of microstructure and durability of alternative binders for concrete, capable to autonomously use advanced analytical techniques provided by regional instrumentation network and trained by international centres of knowledge and excellence in the specific research field. After the project ABC research group will continue to be sustainable through competitive participation in European Research Area.]]></summary_en></project><project>
<id>6985</id><title_hr><![CDATA[Hrvatske filozofkinje u europskom kontekstu]]></title_hr><title_en><![CDATA[Croatian women philosophers in the European context]]></title_en><user_id>3152</user_id><user_firstLast_name>Luka Boršić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-1763</code><acronim><![CDATA[CroWomPhil]]></acronim><duration>01.01.2018 - 31.12.2022</duration><status>Završio</status><financ_value>102.200,52 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filozofija, </scie_field_hr><scie_field_en>Philosophy, </scie_field_en><institution_hr><![CDATA[Institut za filozofiju]]></institution_hr><institution_en><![CDATA[Institute for Philosophy in Zagreb]]></institution_en><team_members_id>2634, 17758, 25011, 3877, </team_members_id><team_members_names><![CDATA[Ivana Skuhala Karasman, Ana Maskalan, Matko Gjurašin, Ankica Čakardić, ]]></team_members_names><keywords_hr><![CDATA[filozofkinje, Hrvatska, povijest, filozofija, feminizam]]></keywords_hr><keywords_en><![CDATA[women philosophers, Croatia, history, philosophy, feminism]]></keywords_en><summary_hr><![CDATA[U projektu Hrvatske filozofkinje u europskom kontekstu imamo dva cilja:1. Prvi je cilj analitički proučiti hrvatske filozofkinje od počeka do naših dana i potom napisati monografsku povijest filozofije koja bi bila posvećena isključivo hrvatskim ženama u filozofiji u Hrvatskoj ili vezano uz Hrvatsku. Ovim proučavanjem hrvatskih filozofkinja i publikacijama o njima želimo ispuniti prazninu u sustavnom proučavanju našeg intelektualnog i društvenog nasljeđa budući da dosad u Hrvatskoj nema ni jedne povijesti filozofije, udžbenika ili kompendija u kojem bi se analizirale i sustavno prezentirale filozofske misli filozofkinja u Hrvatskoj ili vezanim za Hrvatsku. Rezultati našeg projekta bili bi sustavno i cjelovito istražene sljedeće filozofkinje: Mare Gundulić Gučetić, Helene Druskowitz, Elza Kučera, Ivana Rossi, Elly Ebenspanger, Marija Brida, Heda Festini, Blaženka Despot, Jasenka Kodrnja i Gordana Bosanac.2. Drugi je cilj uspostaviti Centar za istraživanje žena u filozofiji (CIŽUF) koji bismo osnovali pri Institutu za filozofiju u Zagrebu po uzoru na slične takve centre u Europi što dopušta Statut i Strategija Instituta za filozofiju. Osim proučavanja života i djela hrvatskih filozofkinja, CIŽUF bi istraživao recepcije stranih filozofkinja u Hrvatskoj i hrvatskih filozofkinja izvan Hrvatske, povijest feminizma, feminističke metateorije te žene kao predmeta filozofskog bavljenja. CIŽUF bi poticao suradnju s pojedincima i institucijama iz svih znanstvenih područja koji bi iskazali interes za interdisciplinarno istraživanje vezano uz predmete bavljenja CIŽUF. Oblici aktivnosti CIŽUF bi bili sljedeći: sastavljanje knjižnice, recepcija svjetskih filozofkinja u Hrvatskoj i ostalih tema kojima se CIŽUF bavi; organiziranje znanstvenih skupova, okruglih stolova, radionica, ljetnih škola, javnih predavanja, izložaba i ostali rad na popularizaciji i diseminaciji i razmjeni znanja; održavanje i izrada mrežne stranice; različita tiskana izdanja, prijevodi, zbornici itd.]]></summary_hr><summary_en><![CDATA[Our project &#39;&#39;Croatian women philosophers&#39;&#39; contains two main goals:1. The first goal is an analytic examination of Croatian women philosophers from the beginning to our day and then to write the monographic history of philosophy that would be devoted exclusively to Croatian women in philosophy in Croatia or in relation to Croatia. The results of our project would offer a complete and systematic research of Croatian women philosophers especially with respect to their ties and mutual influences of the wider European context since a systematic reserach into Croatian women philosophers has not yet been done in Croatia.. The focus of our study will be put on the following women philosophers: Mare Gundulić Gučetić, Helene (von) Druskowitz, Elza Kučera, Ivana Rossi, Elly Ebenspanger, Marija Brida, Heda Festini, Blaženka Despot, Jasenka Kodrnja i Gordana Bosanac.The second goal is foundation of a “Research center for women in philosophy (RCWP)” modelled on similar centres in Europe. The host institution of RCWP would be Institute of Philosophy in Zagreb and RCWP would be dedicated to the historical-philosophical study of women philosophers in Croatia and the close parts of the European environment. Areas of research of RCWP would be: Croatian women philosophers, non-Croatian women philosophers who lived or live in Croatia and/or are otherwise connected with Croatia, reception of non-Croatian women philosophers in Croatia, reception of Croatian women philosophers outside Croatia, the history and development of feminism(s) in Croatia, feminist metatheory, and woman as an object of philosophical studies. Activities of RCWP would be: creating a library, organization of scientific conferences, roundtables, workshops, summer schools, public lectures, exhibitions and other activities aiming at popularization and dissemination and exchange of knowledge; creating and maintaining a bilingual Croatian-English web page (Women in philosophy). various publications, translations etc.]]></summary_en></project><project>
<id>6986</id><title_hr><![CDATA[Dobrobit, pripadnost i društvena pravednost]]></title_hr><title_en><![CDATA[Well-being, affiliation and social justice]]></title_en><user_id>3291</user_id><user_firstLast_name>Nebojša Zelič</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-3462</code><acronim><![CDATA[Dobrobit/WellBeing]]></acronim><duration>01.01.2018 - 31.12.2022</duration><status>Završio</status><financ_value>75.205,52 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filozofija, </scie_field_hr><scie_field_en>Philosophy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Filozofski fakultet u Rijeci]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>22778, 896, 19830, 26568, </team_members_id><team_members_names><![CDATA[Ana Gavran Miloš, Ana Petek, Ivan Cerovac, Tamara Crnko, ]]></team_members_names><keywords_hr><![CDATA[Dobrobit, pravednost, pripadnost, jednakost, teorija sposobnosti]]></keywords_hr><keywords_en><![CDATA[Well-being, justice, affiliation, equality, capability approach]]></keywords_en><summary_hr><![CDATA[Projekt Dobrobit, pripadnost i društvena pravednost ima četiri specifična cilja istraživanja:(1) Prvo, cilj je istražiti dosadašnju raspravu o teorijama koje prihvaćaju vrijednosni pluralizam ali ujedno smatraju da modeli socijalne pravednosti mogu i trebaju biti usmjereni ka postizanju određenih funkcija koje čine život dobrim. Sukladno tome, cilj nam je pokazati da postoji jedna koncepcija dobrog života, a to je dobrobit određena kao zadovoljenje minimuma sposobnosti kako ih određuje Nussbaum, koja osigurava ljudsko dostojanstvo.(2) Drugo, istraživanje u sljedećem koraku ima za cilj ispitati važan aspekt određenja ljudskog dostojanstva, a to je pripadnost zajednici. S obzirom na to, cilj nam je pokazati da je za dobrobit ljudskog života važno promicati pripadnost zajednici.(3) Treći cilj istraživanja je pokazati na koji način naše razumijevanje TS i promicanje pripadnosti može pružiti puno bolji okvir socijalne pravednosti u čije središte ulaze pojmovi socijalne (a ne samo distributivne) nejednakosti, detektirajući na koje bi se funkcije više trebala usmjeriti pažnja u razvijanju javnih politika koje streme ka socijalnoj jednakosti.(4) Cilj empirijskog dijela istraživanja je opisati iskustva članova neprivilegiranih ciljanih skupina hrvatskih javnih politika s obzirom na relevatnost pojedinih sposobnosti, na specifične okolnosti razvoja pojedinih sposobnosti, utjecaj ekonomskog, društvenog i političkog konteksta na  ostvarivanje pojedinih sposobnosti, te efekte različitih državnih mjera na sposobnosti i dobrobit pojedine grupe.]]></summary_hr><summary_en><![CDATA[Project Well-being, affiliation and social justice has four specific research objectives:(1) First, the aim is to explore the current discussion on the theories that accept value pluralism, but also believe that social justice models may and should be directed towards achieving certain functions that make good life. Accordingly, our aim is to show that there is a concept of good life, and that it is determined by the capabilities which ensure human dignity.(2) The second aim is to examine an important aspect of human dignity. Here we want to show that human dignity and well-being as such are established upon the specific capability for affiliation. Unlike other capability theorist we want precisely to claim that it is particularly important to promote community affiliation in order to promote well-being specific for human life.(3) In the  next step of the study, the aim is to show how our understanding of the CA and promotion of affiliation can provide insights for the state and policy makers on the development of public policies that strive for social equality, by identifying those capabilities and functionings that should be focused on in order to promote well-being.(4) The aim of empirical part of the project is to describe the experiences of the underprivileged target groups of Croatian public policies about the relevance of certain capabilities; the specific circumstances of the development of different capabilites; the influence of the economic, social and political context on the achievement of different capabilities; and the effects of different state measures on the capabilities and well-being of the specific groups.]]></summary_en></project><project>
<id>6990</id><title_hr><![CDATA[Dinamika u sustavima u kojima postoji mikro-segregacija]]></title_hr><title_en><![CDATA[Dynamics in micro-segregated systems]]></title_en><user_id>5591</user_id><user_firstLast_name>Bernarda Lovrinčević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-1863</code><acronim><![CDATA[DINAMIS]]></acronim><duration>10.09.2018 - 09.09.2023</duration><status>Završio</status><financ_value>119.249,23 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Science]]></institution_en><team_members_id>5569, 855333, </team_members_id><team_members_names><![CDATA[Martina Požar, Ivo Jukić, ]]></team_members_names><keywords_hr><![CDATA[dinamika, mikro-segregacija, simulacije, vodene otopine, dinamička teorija funkcionala gustoće]]></keywords_hr><keywords_en><![CDATA[dynamics, micro-segregation, simulation, aqueous mixtures, dynamical density functional theory]]></keywords_en><summary_hr><![CDATA[Kompleksne mješavine, kao što su vodene otopine, imaju vrlo specifičnu strukturu koja proizlazi iz specifičnog tipa interakcija, kao što su hidrofobne i hidrofilne interakcije. To rezultira mikro-segregacijom molekula koje u nekim sustavima dovode do stvaranja novih objekata, kao što su micele ili domene. Međutim, informacije o dinamici tih novoformiranih struktura prilično su rijetke, posebno u području simulacija molekularne dinamike, gdje rezultati snažno ovise o računalnim resursima. Ovaj projekt ima za cilj poboljšati razumijevanje životnog vijeka novoformiranih objekata i njihovu kinetiku, što je problem koji se nalazi u srži biofizike, gdje se objekti kao što su membrane konstruiraju od lipidnih molekula u vodenom okolišu. Teorijsko istraživanje dinamike tekućih tvari razvilo se od ranih dana fizike tekućina (1970). Dok je primjena na jednostavne tekućine potvrdila valjanost raznih teorijskih pristupa, primjena na vodene otopine, naročito ne-elektrolita, bila je vrlo rijetka. Smatra se da su simulacije molekularne dinamike bolji način istraživanja tih sustava. U tom kontekstu za teoretičara, poželjno je razviti i testirati alate statističke fizike tekućina za ove otopine. Posebno, poželjno je razumjeti zašto te metode nisu primjenjive na te otopine na isti način kao i na  jednostavne tekućine. Ovaj problem nas navodi da se zapitamo što čini ključnu razliku između jednostavnih i složenih tekućina. Proteklih godina smo proučavali ovaj problem upravo sa statičkog stajališta. Osnovna razlika je da su složene otopine mikro-segregirane, s domenama u rasponu veličina od 1 do 5 nm. To se događa zbog međusobnih konkurentskih interakcija vodikovih veza, koje omogućuju samo-udruživanje molekula putem malih domena.]]></summary_hr><summary_en><![CDATA[Complex mixtures, such as aqueous mixtures, have a very particular structure that stems from the specific type of interactions, namely the hydrophobic and the hydrophilic interaction. This results in micro-segregation of molecules which in some systems leads to the creation of new objects, such as micelles or domains. However, the information about the dynamics of these newly formed structures are rather scarce, especially in the field of molecular dynamics simulations, where the results strongly depend on the computational resources. This projects aims at understanding the lifetime of newly formed objects and their kinetics, which is a problem that lies at the heart of biophysics and material science, where objects such as membranes are being constructed from lipid molecules in water milieu. The theoretical investigation of the dynamics of liquid matter have been developed since the early days of the physics of the liquid state (1970). While the application to simple liquids has confirmed the validity of the various theoretical developments, the extension to aqueous mixtures, and in particular non-electrolytes, have been very scarce. Molecular Dynamics simulations are thought to be a better way to explore these systems. In this context, and for a theoretician, it is desirable to develop and test the tools of statistical physics of liquids for these mixtures. And more particularly, it is desirable to understand why these methods do not apply to these mixtures in the same manner they apply for simple liquids. This problem sends us to ask what makes the essential difference between simple and complex liquids. And it turns out that we have precisely studied this problem in the past years, from static point of view. The principal difference is that complex mixtures are micro-segregated, with species domains in the 1-5 nm range. This is due to competing hydrogen bond interactions, which tend to favour self-association of species over small domains.]]></summary_en></project><project>
<id>6991</id><title_hr><![CDATA[Primjena inovativnih tehnika ekstrakcije bioaktivnih komponenti iz nusproizvoda biljnoga podrijetla]]></title_hr><title_en><![CDATA[Application of innovative techniques of the extraction of bioactive components from by-products of plant origin]]></title_en><user_id>3836</user_id><user_firstLast_name>Stela Jokić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-9909</code><acronim><![CDATA[ByProExtract]]></acronim><duration>01.01.2018 - 31.12.2022</duration><status>Završio</status><financ_value>213.379,62 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Prehrambena tehnologija, </scie_field_hr><scie_field_en>Food technology, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Prehrambeno-tehnološki fakultet]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Food Technology]]></institution_en><team_members_id>7395, 19191, 19195, 22686, 24555, 25722, 862787, </team_members_id><team_members_names><![CDATA[Ines Banjari, KRUNOSLAV ALADIĆ, Nika Pavlović, Senka Vidovic, Marija Banožić, Silvija Šafranko, Jelena Vladic Vladic, ]]></team_members_names><keywords_hr><![CDATA[ekstrakcija, zelene tehnologije, bioaktivne komponente, nusproizvod, optimizacija]]></keywords_hr><keywords_en><![CDATA[extraction, green technologies, bioactive components, byproduct, optimization]]></keywords_en><summary_hr><![CDATA[Cilj svake proizvodnje (industrije) je dobivanje kvalitetnog proizvoda, uz što bolje iskorištenje sirovine. Tijekom prerade sirovine nastaje određena količina nusproizvoda koji nužno ne moraju biti otpad i “problem” nego visokovrijedna sirovina za razvoj novih proizvoda. Kakao ljuska, otpad iz proizvodnje duhana i kore citrusa su nusproizvodi koji nastaju u velikim količinama i  koji su još uvijek nedovoljno istraženi i iskorišteni unatoč sadržaju značajnih korisnih tvari. Cilj ovog projekta je proizvodnja ekstrakata iz navedenih nusprozvoda primjenom šest inovativnih zelenih ekstrakcijskih tehnika: superkritične fluidne ekstrakcije, ekstrakcije vodom u supkritičnom stanju, ekstrakcije potpomognute mikrovalovima, ekstrakcije potpomognute ultrazvukom, ekstrakcije potpomognute hladnom plazmom i ekstrakcije eutektičkim otapalima. U određivanju ciljanih bioaktivnih komponenti iz odabranih nusproizvoda primjenit će se visokosofisticirane kromatografske tehnike. Zbog velike raznolikosti bioaktivnih komponenti iz odabranih nusproizvoda, za svaku primijenjenu tehniku ekstrakcije definirat će se optimalni procesni parametri primjenom metode odzivnih površina. Ekstrakti s najvećim biološkim potencijalom će se postupkom sušenja raspršivanjem prevesti u praškasti oblik s potencijalnom komercijalnom primjenom.Rezultati istraživanja doprinjeti će rješenju problema velikih količina organskog otpada koji predstavlja ogroman ekološki i financijski teret u svim segmentima procesne industrije. Naglasak projekta je na potencijalnoj komercijalnoj valorizaciji rezultata istraživanja i transferu dobivenih rezultata u industriju, kao i na jačanju veze akademske zajednice s industrijom s ciljem ekonomskog razvoja i boljitka cijelog društva.]]></summary_hr><summary_en><![CDATA[All industries aim to obtain a quality product and to utilise raw materials as efficiently as possible in the production process. During the processing of raw materials, a certain amount of by-products is produced, which does not necessarily have to be “waste”, but a by-product or high value raw material for development of new products. Cocoa shells, tobacco waste, and citrus peels, are by-products produced in large quantities which are usually underutilized or considered as waste, in spite of the fact that they contain different classes of useful components. The aim of this project is to obtain extracts rich in bioactive components from selected by-products using six innovative green extraction techniques: supercritical fluid extraction (SFE), subcritical water extraction (SWE), microwave-assisted extraction (MAE), ultrasound-assisted extraction (UAE), cold atmospheric plasma assisted extraction (CAPAE), and extraction using deep eutectic solvents (DES). Determination and isolation of bioactive components from selected by-products will be performed using highly sophisticated chromatographic techniques. Due to great diversity of bioactive components from diverse material, optimal extraction conditions will be defined for each applied technique by using response surface methodology (RSM). Extracts with the highest biological potential will be dried by using spray drying technology in order to produce plant powders with potential commercial application. The results of the research will contribute to solving the problem of large quantities of organic waste, which represents an enormous ecological and financial burden for all aspects of the process industry. Special emphasis in the project will be put on the possible commercial valorisation of the research results and on the transfer of those results to the application level, as well as on strengthening the relationship between the academic community and the industry.]]></summary_en></project><project>
<id>6992</id><title_hr><![CDATA[Dinamičnost kategorija specijaliziranoga znanja]]></title_hr><title_en><![CDATA[Dynamicity of Specialized Knowledge Categories]]></title_en><user_id>2897</user_id><user_firstLast_name>Ana Ostroški Anić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-7169</code><acronim><![CDATA[DIKA]]></acronim><duration>10.03.2018 - 09.03.2023</duration><status>Završio</status><financ_value>118.848,48 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filologija, </scie_field_hr><scie_field_en>Philology, </scie_field_en><institution_hr><![CDATA[Institut za hrvatski jezik]]></institution_hr><institution_en><![CDATA[Institute of Croatian Language]]></institution_en><team_members_id>1143, 2892, 22580, 7422, 22698, 25084, </team_members_id><team_members_names><![CDATA[Maja Lončar, Ivana Brač, Ivanka Rajh, Martina Bajcic, Larisa Grčić Simeunović, Martina Pavić, ]]></team_members_names><keywords_hr><![CDATA[terminologija, semantički okviri, semantika okvira, specijalizirano znanje, specijalizirana komunikacija]]></keywords_hr><keywords_en><![CDATA[terminology, semantic frames, Frame Semantics, specialized knowledge, specialized communication]]></keywords_en><summary_hr><![CDATA[Glavni je cilj projekta Dinamičnost kategorija specijaliziranoga znanja uspostaviti istraživačku grupu koja će provoditi međunarodno relevantna istraživanja iz područja terminologije. U okviru provodit će se istraživanja pojmovne i jezične razine terminoloških jedinica i kategorija specijaliziranoga znanja, zatim sintaktičko – semantička istraživanja sintagmatskih sveza naziva te diskursna istraživanja komunikacijske uloge naziva u strukovnim područjima zrakoplovstva, prava, marketinga i krša. Istraživanja će se provoditi primjenjujući teorijske postavke i spoznaje semantike okvira i terminologije okvira te oslanjajući se na komunikacijsku terminološku teoriju i sociokognitivni terminološki pristup. Kontrastivnim analizama prijevodnih ekvivalenata u hrvatskom, engleskom, njemačkom i francuskom jeziku doprinijet će se teorijskim istraživanjima stručnoga prevođenja. Primijenjeni su rezultati projekta englesko – hrvatski paralelni korpus tekstova iz domene zračnog prometa te terminološka baza okvira AirFrame u kojoj će nazivlje iz područja zrakoplovstva biti definirano u semantičkim okvirima s odgovarajućim elementima okvira, pojmovnim odnosima, figurativnim i frazeološkim terminološkim jedinicama. Zrakoplovni nazivi, definicije i jezični kontekst na hrvatskom jeziku pratit će ekvivalenti naziva i konteksta na trima jezicima: engleskom, francuskom i njemačkom. Na taj će se način izgraditi deskriptivna terminološka baza usmjerena prevoditeljskim potrebama, ali i postaviti model za izgradnju slične višedomenske i višejezične baze znanja hrvatskoga jezika.]]></summary_hr><summary_en><![CDATA[The main objective of the project Dynamicity of Specialized Knowledge Categories is establishing a research group that will work on internationally competitive research topics in the field of terminology. Theoretical research of terminological units and specialized knowledge categories at conceptual and linguistic levels, syntactic and semantic analyses of the syntagmatic term relations, as well as theoretical research of the communicative functions of terms in discourse based on examples from the domains of aviation, law, marketing and karstology. The research follows the theoretical framework of Frame Semantics and Frame-based Terminology, taking into account relevant findings from the Communicative Theory of Terminology and the Sociocognitive terminology theory. Contrastive analyses of the translation equivalents in Croatian, English, German and French will contribute to the development of theoretical research in the field of specialized translation. The project’s applied results include an English – Croatian parallel corpus in the domain of air traffic, and the terminological database of semantic frames AirFrame, in which the aviation terminology is defined in semantic frames including semantic elements, conceptual relations, and figurative and phraseological terminological units. English, French and German equivalents of terms and linguistic contexts are added to the Croatian part of the aviation terminology. A translator-oriented descriptive terminological database created following this methodology will serve as a model for the creation of a similar multidomain and multilingual knowledge base of the Croatian language.]]></summary_en></project><project>
<id>6993</id><title_hr><![CDATA[Uloga bradikinina u ishemiji mozga i mrežnice u mišjim modelima dijabetesa]]></title_hr><title_en><![CDATA[The role of bradykinin in brain and retinal ischemia in diabetic murine models]]></title_en><user_id>6226</user_id><user_firstLast_name>Marina Radmilović (Dobrivojević)</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-8082</code><acronim><![CDATA[BRADISCHEMIA]]></acronim><duration>01.09.2018 - 31.03.2024</duration><status>Završio</status><financ_value>261.463,93 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>19920, 22669, 22672, 22761, 5583, 22595, 25188, 25294, 865161, 25363, </team_members_id><team_members_names><![CDATA[Anton Glasnović, Grosche Antje, Dirk Wiedermann, Marin Radmilović, Zoran Vatavuk, Sandra Grgić, Helena Justić, Anja Barić, Marta Pongrac, Martina Ratko, ]]></team_members_names><keywords_hr><![CDATA[dijabetes, ishemija, bradikinin, moždani udar, dijabetička retinopatija]]></keywords_hr><keywords_en><![CDATA[diabetes, ischemia, bradykinin, stroke, diabetic retinopathy]]></keywords_en><summary_hr><![CDATA[Dijabetes je kronična bolest koja obuhvaća metaboličke poremećaje obilježene povišenom razinom glukoze u krvi kao posljedicom nedovoljne proizvodnje inzulina, rezistencije na djelovanje inzulina ili obaju mehanizama. Trenutno pola milijarde ljudi diljem svijeta ima dijabetes. Tijekom trajanja dijabetesa, trećina oboljelih razvije ishemijski moždani udar,  trećina razvije dijabetičku retinopatiju, a obje navedene komplikacije dovode do ozbiljnog invaliditeta s neizmjernim socioekonomskim utjecajem. S patofiziološkog gledišta, i dijabetička retinopatija i moždani udar karakterizirani su ishemijom. Bradikinin je među prvim upalnim čimbenicima koji se javljaju s nastupom ishemije. Bradikinin povećava permeabilnost krvno-moždane/-žilnične barijere, inducirajući nastanak edema. Budući da aktivacija njegovih receptora pridonosi nastanku edema i oštećenju tkiva modulacijom post-ishemijskog upalnog odgovora, potraga za inhibitorima koji bi mogli smanjiti te štetne učinke postala je važan cilj. Ipak, uloga bradikininskih receptora nije jednostrana, budući da su zabilježeni i razni povoljni učinci njihove aktivacije, poput prevencije odumiranja endotelnih stanica, redukcije glutamatne neurotoksičnosti, te preživljenja i migracije glija stanica. Ova dovojaka uloga bradikininskih receptora poticaj je za naše istraživanje, kojim ćemo istražiti ulogu bradikininskog receptora tipa 2 u dvama specifičnim komplikacijama koje se razvijaju u tijeku dijabetesa: dijabetičkoj retinopatiji i moždanom udaru. Korištenjem uspostavljenih modaliteta snimanja magnetskom rezonancijom, omogućit će nam longitudinalno praćenje razvoja ishemijske moždane ozljede. Također planiramo unutar već uspostavljenog laboratorija razviti s novu platformu za multimodalno pretkliničko istraživanje bolesti mrežnice, prvu platformu takve vrste u Republici Hrvatskoj, a koja bi otvorila mogućnosti novim i sveobuhvatnijim pretkliničkim istraživanjima ekperimentalnih terapija i učinkovitijoj translaciji prema klinici.]]></summary_hr><summary_en><![CDATA[Diabetes mellitus is a chronic disease that comprises metabolic conditions characterized by elevated blood glucose levels resulting from either inadequate insulin production, resistance to insulin action, or both. Currently, half a billion people are affected by diabetes worldwide. During the course of the disease, one-third of diabetic patients develop ischemic stroke, one third develop diabetic retinopathy, both leading to severe disabilities with immense socioeconomic impact. Pathophysiologicaly, both diabetic retinopathy and stroke are characterized by ischemia. Bradykinin is one of the first inflammatory factors released during the ischemia. Bradykinin increases the blood-brain/retinal barrier permeability, inducing edema formation. Since activation of bradykinin receptors contributes to brain edema and tissue damage modulating the post-ischemic inflammatory response, the search for inhibitors that could diminish these detrimental effects has become an important issue. However, the role of bradykinin receptors is not so unambiguous, since different beneficial effects of their activation were also shown in preventing endothelial cell death, lowering glutamate neurotoxicity, and enhancing glial cell survival and migration. This ambiguous role of the bradykinin receptors is what prompts our research, which will be achieved through the research of the role of bradykinin in two distinct complications that occur in the course of diabetes: diabetic retinopathy and ischemic stroke. By using magnetic resonance imaging modalities, we aim to perform a longitudinal study of the progression of cerebral ischemia. Within the established imaging facility, we plan to set up a completely new platform for multimodal preclinical research of retinal diseases, which would be the first platform of its kind in Croatia and would open up possibilities for novel more comprehensive preclinical evaluation of experimental therapies with a more efficient preclinical to clinical translation.]]></summary_en></project><project>
<id>6994</id><title_hr><![CDATA[Razvoj modela za povećanje efikasnosti izrade i funkcionalnosti grafičke ambalaže]]></title_hr><title_en><![CDATA[Development of the model for production efficiency increase and functionality of packaging]]></title_en><user_id>19215</user_id><user_firstLast_name>Tomislav Cigula</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-4081</code><acronim><![CDATA[MEGA]]></acronim><duration>15.02.2018 - 14.02.2023</duration><status>Završio</status><financ_value>133.638,60 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Grafička tehnologija, </scie_field_hr><scie_field_en>Graphics technology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Grafički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Graphic Arts]]></institution_en><team_members_id>22684, 3559, 5900, 19216, 25166, 26526, 865526, </team_members_id><team_members_names><![CDATA[Ante Poljičak, Tamara Tomašegović, Marija Prša, Davor Donevski, Tomislav Hudika, Petar Branislav Jelušić, Marina Vukoje, ]]></team_members_names><keywords_hr><![CDATA[grafička ambalaža, GCR, digitalni vodeni žig, funkcionalni premaz, matematičko modeliranje]]></keywords_hr><keywords_en><![CDATA[packaging, GCR, digital watermark, functional coatings, mathematical modeling]]></keywords_en><summary_hr><![CDATA[Grafička tehnologija je polje iz grane tehničkih znanosti s visokim stupnjem primjenjivosti u sustavima koji se naslanjaju na tehnološke napretke u području računarskih znanosti i inženjerstva i znanosti o materijalima. Specifičnost ovog istraživačkog područja jest upravo dvosmjerna veza između digitalnog okruženja koje se odnosi na manipulaciju i obradu slikovnih informacija i „realnog“ okruženja u kojem se navedene informacije reproduciraju koristeći različite materijale. Ovo istraživanje se provodi s ciljem razvoja modela za povećanje efikasnosti izrade i funkcionalnosti grafičke ambalaže. Navedeni cilj postići će se kroz provođenje grupa aktivnosti koje bismo mogli podijeliti u četiri osnovne skupine:-	Razvoj i evaluacija metode za zamjenu kromatskih boja akromatskom komponentom(GCR)-	Razvoj metode za implementaciju digitalnog vodenog žiga kao sredstva zaštite grafičke reprodukcije-	Karakterizacije grafičkih materijala i razvoj funkcionalnih premaza te analizom njihovih utjecaja karakteristika na višebojnu reprodukciju-	Razvoj i ocjena matematičkog modela koji će povezati utjecaj elemenata modulacije slikovne informacije i karakteristika materijala te oplemenjivanja otisaka na mehanička svojstva i vizualnu percepciju reprodukcijeOčekuje se da će rezultati ovog istraživanja doprinijeti povećanju konkurentnosti proizvodnje ambalažnog proizvoda, uz istovremeno povećanje funkcionalnosti kroz implementaciju zaštitnih elemenata u slikovni zapis te oplemenjivanje materijala poboljšavajući mu mehanička svojstva te vizualnu percepciju.Dodatni aspekt projektnog prijedloga je razvoj istraživačkog kapaciteta kroz uvođenje mladih znanstvenika u istraživački proces te njihovo usavršavanje kroz doktorski studij, pripremu publikacija te prezentacijom rezultata i diskusiji sa stručnjacima iz područja na znanstvenim skupovima.]]></summary_hr><summary_en><![CDATA[Graphic technology is a part of technical sciences which implements research advances in the various fields including computer science ad material sciences. This fact leads to a specific approach to the research as one must always have in mind the two way communication between image data manipulation in the digital and materials interaction in the printing process and product finishing.  The aim of this research proposal is to develop the model for production efficiency increase and functionality of packaging. This goal will be achieved by conducting of activities which could be divided in four main groups:- development and evaluation of the grey colour replacement (GCR) method- development of the method for implementing digital watermark as a mean to enable graphic reproduction protection- characterization of graphic materials and development of functional coatings and their impact on the multicolour graphic reproduction- development and evaluation of the mathematical model which will make connection between influence of the digital image modulation and material&#39;s characteristics and prints refining on it&#39;s mechanical properties and visual perception.It is expected that results of this research will contribute to the increase of the packaging production competitiveness, but simultaneously increase packaging functionality by implementing protecting elements in the image and material refinement to increase it&#39;s mechanical properties and visual perception.In addition, conducting of this project proposal will enable development of the research capacity by introducing young researchers into the research processes and specialization through finishing the PhD study, preparing research papers and presenting them at scientific conferences where they will be involved in discussions with researchers in the field.]]></summary_en></project><project>
<id>7000</id><title_hr><![CDATA[Matematička analiza i numeričke metode za višefazne sustave vođene difuzijom]]></title_hr><title_en><![CDATA[Mathematical analysis and numerical methods for diffusion driven multiphase systems]]></title_en><user_id>5872</user_id><user_firstLast_name>Mario Bukal</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-7249</code><acronim><![CDATA[MANDphy]]></acronim><duration>01.03.2018 - 31.08.2023</duration><status>Završio</status><financ_value>118.058,27 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>3179, 72, 865249, </team_members_id><team_members_names><![CDATA[Anja Vrbaški, Marko Erceg, Matija Livaić, ]]></team_members_names><keywords_hr><![CDATA[višefazni sustavi, nelinearna difuzija, unakrsna difuzija, homogenizacije, numeričke metode koje čuvaju strukturu]]></keywords_hr><keywords_en><![CDATA[multiphase systems, nonlinear diffusion, cross-diffusion, homogenization, structure preserving numerical schemes]]></keywords_en><summary_hr><![CDATA[Projekt se bavi teorijskim aspektima i numeričkom analizom parcijalnih diferencijalnih jednadžbi koje opisuju sustave s više faza, a javljuju se u fizici, biologiji i geologiji. Točnije, bavit ćemo se parcijalnim diferencijalnim jednadžbama koje opisuju: (i) dinamiku granice između dviju odvojenih faza (npr. granica zrak / tekućina ili tekućina / tekućina u tankim viskoznim fluidima, granica u sustavima spinova itd.) i (ii ) dinamiku gustoće ili volumnih udjela faza (npr. nemješive tekućine u poroznom mediju, viševrsni modeli u biologiji, kemiji itd.). U svim tim jednadžbama &#39;&#39;pokretačka sila&#39;&#39; dinamike proizlazi iz difuzijske strukture jednadžbe: degenerirana difuzija u obliku prostornih derivacija četvrtog reda (i) i sustav nelinearnih difuzijskih i unakrsnih difuzijskih jednadžbi (ii). Motivacije za proučavanje takvih sustava proizlaze iz brojnih i raznovrsnih primjena, što mi ocrtavamo kroz četiri scenarija: (1) fluktuacija granice u  sustavima spinova, (2) dinamika tankog viskoznog fluida s toplinskim efektima, (3) sanacija nafte u spremnicima ugljikovodika i (4) viševrsni biološki naliči za obradu otpadnih voda. Naši glavni ciljevi su analiza postojanja fizikalno relevantnih slabih rješenja, analiza njihovih kvalitativnih svojstava (dugoročno ponašanje, sebi-sličnost rješenja, eksplozija ili prekid itd.), izvod homogeniziranih (makroskopskih) modela za modele s višeskalnom prirodom poput modela  bioloških naliča za obradu otpadnih voda, i konačno, konstrukcija pouzdanih numeričkih metoda, koje čuvaju strukturu jednadžbi i u stanju su dohvatiti kvalitativna opažanja. Uspješna provedba ovog projekta doprinijet će najnovijim saznanjima u području istraživanja i bit će dodana vrijednost zajednici primijenjene matematike u Hrvatskoj.]]></summary_hr><summary_en><![CDATA[The project deals with theoretical aspects and numerical analysis of partial differential equations, which describe systems with multiple phases arising in physics, biology and geology. More precisely, we are interested in partial differential equations describing: (i) dynamics of the interface between two separated phases (e.g. air/liquid or liquid/liquid interface in thin viscous films, interface in spin systems, etc.), and (ii) dynamics of densities or volume fractions of system phases (e.g. immiscible fluid flows in porous medium, multispecies models in biology, chemistry, etc.). In all these equations the &#39;&#39;driving force&#39;&#39; of the dynamics emanates from the diffusion structure of the equation: degenerate diffusion in terms of fourth-order spatial derivatives (i), and systems of nonlinear diffusion and cross-diffusion equations (ii). Motivations for studying such systems arise from numerous and versatile applications and we render it through four application scenarios: (1) interface fluctuations in spin systems, (2) dynamics of thin viscous fluids with thermal effects, (3) oil recovery in hydrocarbon reservoirs, and (4) multispecies biofilms for wastewater treatment. Our main goals are to undertake the existence analysis of physically relevant weak solutions, analysis of their qualitative properties (long-time behaviour, self-similarities, blow-up or rupture, etc.), derivation of homogenized (macroscopic) models for models of multiscale nature like the biofilm model for wastewater treatment, and finally, to construct reliable structure preserving numerical schemes, which are able to capture qualitative observations. Successful implementation of this project will contribute to the state of the art in the research field and will be an added value to the Croatian applied mathematics community.]]></summary_en></project><project>
<id>7002</id><title_hr><![CDATA[Konsocijacija drvenastih vrsta i poljoprivrednih kultura kao inovativni pristup u agroekosustavima]]></title_hr><title_en><![CDATA[Intercropping of wood species and agricultural crops as an innovative approach in agroecosystems]]></title_en><user_id>20421</user_id><user_firstLast_name>Vladimir Ivezić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-7103</code><acronim><![CDATA[AGROINOVA]]></acronim><duration>01.02.2018 - 31.01.2023</duration><status>Završio</status><financ_value>198.279,41 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Fakultet agrobiotehničkih znanosti Osijek]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Agrobiotechnical Sciences in Osijek]]></institution_en><team_members_id>20380, 19239, 18940, 22803, 20436, 22802, 28689, 858405, </team_members_id><team_members_names><![CDATA[Josipa Puškarić Puškarić, Brigita  Popović, Miro Stošić, Jurica Jović, Vladimir  Zebec, jelena ilić, Helena Žalac, Ante Bubalo, ]]></team_members_names><keywords_hr><![CDATA[konsocijacija, orah, poljoprivredni usjevi, mikroklima, biološka raznolikost, konzervacija tla]]></keywords_hr><keywords_en><![CDATA[Intercopping, walnut, agricultural crops, microclimate, biodiversity, soil conservation]]></keywords_en><summary_hr><![CDATA[Konsocijacija ili kombinacija kultura podrazumijeva uzgoj više kultura na istoj površini u isto vrijeme. Glavne prednosti konsocijacije su: bolja iskoristivost proizvodne površine, pozitivan utjecaj na plodnost tla, raznolikost proizvodnje u jednoj vegetaciji, zaštita od pojave bolesti, štetnika i korova, bolja iskoristivost hraniva i vode u tlu te povećana biološka raznolikost. U konsocijacijama koje podrazumijevaju uzgoj u nasadima oraha poželjno je odabrati nasade s cijepljenim orasima zbog činjenice da orah luči juglon koji može imati toksičan efekt na nicanje drugih biljaka. Naime, u nasadima oraha s cijepljenim stablima lučenje juglona nije tako intenzivno i djelovanje juglona u prvih 15 godina u takvim nasadima nema značajno toksičan učinak. Isto tako, preporučljivo je unošenje organske tvari jer se time potiče mikrobiološka aktivnost koja pospješuje razgradnju juglona. Drugi važan čimbenik u ovakvim konsocijacijama jest odabir poljoprivrednih kultura koje su otporne na nisku pH vrijednost jer orah eksudatima zakiseljuje tlo.Cilj projektnog prijedloga je istražiti utjecaj međuodnosa cijepljenih oraha i poljoprivrednih kultura na mikroklimu te time na bioraznolikost u tlu (mikrobiološku aktivnost u tlu te strukture zajednice nematoda), konzervaciju tla i štetne organizme poput uzročnika biljnih bolesti. Pokus će biti proveden kroz pet godina, na dva lokaliteta u dvije županije od kojih će se svaki sastojati od tri parcele – kontrolna parcela sa usijanim poljoprivrednim kulturama bez oraha, parcela s nasadom oraha gdje će između redova biti usijane poljoprivredne kulture te trajni nasad oraha bez ratarskih kultura. Na osnovu dobivenih rezultata biti će kreiran kompjuterski model za predviđanje utjecaja mikroklime na istraživane parametre u projektnom prijedlogu. Iako su takvi modeli dostupni u svijetu u Republici Hrvatskoj ovo će biti prvi model takvog tipa koji će biti primjenjiv za agroekološke uvijete u široj regiji, odnosno područje dunavskog sliva.  ]]></summary_hr><summary_en><![CDATA[Intercropping or a combination of plant species involves more species on the same parcel at the same time. The main benefits of the intercropping are: better use of the production area, positive influence on soil, diversity of production, protection against plant disease, pests and weeds, better use of nutrients and water in soil as well as increased biodiversity. In intercropping systems with walnut it is desirable to choose orchards with grafted plants since the walnut tree secretes juglone that may have a toxic effect on the germination of other plants. In the orchards of walnuts with grafted trees, the secretion of juglone is not so intense and the activity of the juglone in the first 15 years in such intercropping systems has no significant toxic effect. Also, it is advisable to introduce organic matter as it promotes microbiological activity that decompose juglone. Another important factor in such systems is the selection of plants resistant to low-pH, since the walnuts can acidify soil.The aim of the proposed project is to investigate the interaction between grafted walnuts and agricultural crops to microclimate and consequently to soil biodiversity (microbiological activity in soil and nematode community structure), soil conservation and occurrence of plant diseases.The field trial will be conducted during five years, at two locations in two Counties, each field trial will consist of three parcels - control plot of agricultural crops without walnuts, walnut orchards with intercropped agricultural crops and a permanent walnut orchard without intercropped agricultural crops. Based on the obtained results, a computer model will be created for predicting the influence of microclimate on the investigated parameters in the project proposal. Although such models are available worldwide in the Republic of Croatia, this will be the first model of such type that will be applicable for agroecological conditions in the wider region, mainly the Danube Basin area.]]></summary_en></project><project>
<id>7003</id><title_hr><![CDATA[Utjecaj specifične površine oplošja čestice na hidrogeološka svojstva prapora i na njima razvijenih tala istočne Hrvatske]]></title_hr><title_en><![CDATA[Impact of specific surface area on hydrogeological properties of loess deposits and loess-derived soils in eastern Croatia]]></title_en><user_id>5920</user_id><user_firstLast_name>Kosta Urumović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-9435</code><acronim><![CDATA[ISSAH]]></acronim><duration>01.02.2018 - 31.01.2023</duration><status>Prekinut</status><financ_value>183.366,89 eur</financ_value><scie_area_hr>Tehničke znanosti, Biotehničke znanosti, Prirodne znanosti, </scie_area_hr><scie_area_en>Technological sciences, Biotechnical sciences, Natural sciences, </scie_area_en><scie_field_hr>Rudarstvo, nafta i geološko inženjerstvo, Geologija, Građevinarstvo, Poljoprivreda, </scie_field_hr><scie_field_en>Mining, petroleum and geological engineering, Geology, Civil engineering, Agriculture, </scie_field_en><institution_hr><![CDATA[Hrvatski geološki institut]]></institution_hr><institution_en><![CDATA[Croatian Geological Survey]]></institution_en><team_members_id>22781, 19631, 22782, 3405, 19512, 22798, 22785, 25274, </team_members_id><team_members_names><![CDATA[Vedran Rubinić, Tamara Dadić, Staša Borović, Jasmina Lukač Reberski, Jasmina Martinčević Lazar, Ivica Pavičić Pavičić, Marina Bubalo Kovačić, Marco Pola, ]]></team_members_names><keywords_hr><![CDATA[prapor, specifična površina oplošja čestice, hidrogeološki parametri, pedološka svojstva , zaštita podzemnih voda]]></keywords_hr><keywords_en><![CDATA[loess, specific surface area, hydrogeological properties, pedological properties, groundwater protection]]></keywords_en><summary_hr><![CDATA[Znanstveni i praktični interes o praporima je izrazito polidisciplinaran. Pri tome su interesantne teme osnovni i akcesorni granulometrijski i petrografski sastav, geometrijska svojstva pora povezanih s veličinom šupljina i specifičnom površinom oplošja krutine), sadržaj organskih tvari i fosilnih ostataka, sadržaj vlage, protočnost i zadržavanje vode, fizikalna i kemijska interakcija sadržane vode i krutine, okolišna hidrografska obilježja, geotehnička svojstva, lokalni i regionalni morfološki položaj i obilježja podinskih naslaga. Strateški značaj prapornih naslaga se za Republiku Hrvatsku prvenstveno temelji na poljoprivrednom i građevinskom korištenju i na zaštiti podzemnih voda. Specifična površina oplošja čestica tla je osnovno fizikalno svojstvo nevezanih i slabo vezanih tvorevina. Veličina specifične površine i petrološka obilježja sadržanih čestica u tlu presudno upravljaju kemijskim i fizikalnim procesima u tlu, a posljedica su kemijskog i mineralnog sastava tla. Isto tako, specifična površina uvjetuje hidrogeološka, geomehanička i pedološka svojstva tala koja imaju ulogu zaštite podzemnih voda, prikladnost za građevinske radove i poljoprivredne podloge. Ovaj je projekt zamišljen kao interdisciplinarno istraživanje utjecaja toga osnovnog fizikalnog parametra tla na mjerilu uzorka na hidrogeološke, geomehaničke, pedološke i poljoprivredne uvjete. Ovim će se projektom oformiti istraživačku grupu mladih hrvatskih znanstvenika iz različitih polja znanosti i usmjeriti ju u istraživanje sitnozrnastih klastičnih naslaga te proizvesti podlogu budućih interdisciplinarnih istraživanja u svrhu zaštite podzemnih voda i efikasnog korištenja zemljišta.Istraživanja bi se provodila na prostoru Baranje, Srijema i Istočne Slavonije gdje prapori i praporu slične tvorevine prekrivaju velike površine. Znanstveno utemeljeno poznavanje njihovih svojstava na konkretnim lokacijama i njihova regionalizacija važna su podloga za aktualni napredak i dugoročni razvitak ovih krajeva.]]></summary_hr><summary_en><![CDATA[Scientific and practical interest in loess deposits is extremely polidisciplinary. Interesting topics are the basic granulometric and petrographic composition, geometric properties of pores associated with size of pores and specific surface area of the solid, organic matter, moisture, permeability and water retention, physical and chemical interaction of the contained water and the solids, environmental hydrographic characteristics, geomechanical properties, local and regional morphology and the characteristics of bedrock. The strategic importance of loess deposits for the Republic of Croatia is based on agricultural and construction use and on the protection of groundwater. Specific surface area of soil particles is the basic physical property of non-cohesive and poorly-cohesive materials. Specific surface area and petrological characteristics of the soil particles are crucial to the chemical and physical processes in the soil, being the result of the chemical and mineral composition of soil. Hydrogeological, geomechanical and pedological properties of soils that have crucial role in groundwater protection, soil suitability for construction works and agricultural substrates are conditioned by the specific surface area. This project is conceived as an interdisciplinary study of the influence of this fundamental physical parameter on hydrogeological, geomechanical, pedological and agricultural conditions. The project will form a research group of young Croatian scientists from different fields of science and focus it on studying fine-grained deposits. It will produce the basis for future interdisciplinary researches for the purpose of groundwater protection and efficient land use. Researches will be conducted in Baranja, Srijem and Eastern Slavonia where loess covers large areas. Scientifically based knowledge of loess properties at specific locations and their regionalization is an important basis for the current progress and long-term development of these regions.]]></summary_en></project><project>
<id>7007</id><title_hr><![CDATA[Ispitivanje i modeliranje mehaničkog ponašanja bioosušenog otpada kao preduvjet energetske oporabe]]></title_hr><title_en><![CDATA[Testing and modelling of mechanical behavior of biodryed waste as a Waste-to-Energy prerequisite]]></title_en><user_id>742</user_id><user_firstLast_name>Igor Petrović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-5157</code><acronim><![CDATA[WtE]]></acronim><duration>01.01.2018 - 30.06.2023</duration><status>Završio</status><financ_value>123.293,85 eur</financ_value><scie_area_hr>Tehničke znanosti, Prirodne znanosti, </scie_area_hr><scie_area_en>Technological sciences, Natural sciences, </scie_area_en><scie_field_hr>Građevinarstvo, Kemijsko inženjerstvo, Temeljne tehničke znanosti, </scie_field_hr><scie_field_en>Civil engineering, Chemical engineering, Basic engineering sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Geotehnički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Geotechnical Engineering]]></institution_en><team_members_id>7418, 25255, 25881, 2527, 858370, </team_members_id><team_members_names><![CDATA[Linke Li, Nikola Kaniški, Nikola Hrnčić, Ivana Melnjak, Dino Bosilj, ]]></team_members_names><keywords_hr><![CDATA[bioosušeni MBO otpadni materijal, projektiranje bioreaktorskog odlagalita, otpad u energiju, mehaničko ponašanje otpada, konstitutivni modeli]]></keywords_hr><keywords_en><![CDATA[biodryed MBT waste material, bioractor landfill design, waste-to-energy, mechanical behavior of waste, constitutive modeling]]></keywords_en><summary_hr><![CDATA[Predloženi projekt orijentiran je na eksperimentalno ispitivanje i numeričko modeliranje mehaničkog ponašanja bioosušenog otpada. Biosušenje je varijacija aerobne razgradnje koja se primjenjuje za parcijalnu stabilizaciju komunalnog otpada. Nakon biosušenja otpad se upućuje u daljnju obradu gdje se izdvaja organski bogata sitnozrnata frakcija pogodna za odlaganje na bioreaktorsko odlagalište. Jednom odložena, ova se frakcija ponovno podvrgava postupku vlaženja, s ciljem energetske oporabe nastalog bioplina za proizvodnju toplinske i/ili električne energije. U RH postoje dva MBO postrojenja s izlaznim proizvodom pogodnim za odlaganje na bioreaktorsko odlagalište.U RH trenutno ne postoje bioreaktorska odlagališta iako Pravilnik o načinima i uvjetima odlaganja otpada (NN 114/15) prepoznaje bioreaktorska odlagališta. Kao jedan od razloga svakako se može istaknuti nedovoljan broj eksperimentalnih podataka o geotehničkim parametrima razmatranog otpada. Drugi razlog je nedostatak prikladnog numeričkog modela za ovu vrstu otpada. Uslijed ovih nedostataka projektiranje bioreaktorskih odlagališta nije moguće.Stoga je glavni cilj predloženog istraživanja razviti, na temelju utvrđenih eksperimentalnih podataka, prikladan konstitutivni model za opisivanje 3-D stanja naprezanja i deformacija sitnozrnate frakcije bioosušenog otpada. Razvijeni model mogao bi se koristiti za potrebe projektiranja bioreaktorskih odlagališta. Model bi svoju primjenu mogao naći ne samo u RH već i u drugim zemljama regije kod kojih MBO tehnologija tek treba biti implementirana.Rezultati ovog projekta omogućit će racionalniji pristup u projektiranju odlagališta otpada, kao i nadopunu Strategije gospodarenja otpadom Republike Hrvatske. Osim toga, rezultati pokusa će pružiti sveobuhvatan skup dobro kontroliranih, novih generičkih mjerila za računalnu validaciju različitih aspekata modeliranja MBO otpada te doprinijeti unaprjeđenju prediktivne snage modela za potrebe projektiranja odlagališta otpada.]]></summary_hr><summary_en><![CDATA[The proposed project is focused on the experimental investigation and numerical modelling of the biodryed waste. Biodrying is a variation of aerobic process which is used for partial stabilization of municipal waste. After biodrying process the waste is submitted for further processing to extract organically rich fine-grained fraction suitable for disposal on a bioreactor landfill. Once disposed, the waste is once again moisturized in order to energetically reuse produced biogas through generation of thermal and/or electrical energy. There are two operating MBT plants in Republic of Croatia whose final product is suitable for disposal on bioreactor landfill.There are no bioreactor landfills built on Croatian territory yet, although the Ordinance on the methods and conditions for the landfill of waste (OG 114/15; R Croatia) recognizes bioreactor landfills.The insufficient experimental data about geotechnical parameters of biodryed waste can be emphasized as one of the reasons. The second reason is the lack of the appropriate numerical model. Due to the mentioned obstacles, the proper design of bioreactor landfill is not feasible. The main goal of the proposal is to develop an appropriate constitutive model for general 3-D stress paths for the fine-grained fraction of biodryed waste. The proposed model can then be used as a design tool for bioreactor landfills. Since a lot of countries in the Danube area should implement waste treatment technologies, the usefulness of the proposed model is not strictly limited to Croatia.The obtained results will allow more rational landfill design and retrofit waste management strategies in Croatia.The experimental results will provide a comprehensive set of well controlled, novel generic benchmarks to computationally validate various modelling aspects of the biodryed MBT waste material and contribute towards its improved predictive power of proposed model for the landfill design purposes. ]]></summary_en></project><project>
<id>7090</id><title_hr><![CDATA[Istraživanje shizofrenije kroz ekspresiju netopivih proteina]]></title_hr><title_en><![CDATA[Characterization of Aggregated Proteins in Neuropsychiatric Disorders, including Drosophila Models]]></title_en><user_id>22771</user_id><user_firstLast_name>Nicholas Bradshaw</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-9424</code><acronim><![CDATA[CandidIskren]]></acronim><duration>08.11.2018 - 07.07.2023</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Biotehnologija, </scie_field_hr><scie_field_en>Biotechnology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Fakultet biotehnologije i razvoja lijekova]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Biotechnology and Drug Development]]></institution_en><team_members_id>23696, 23637, 69, 29297, 29295, 29346, 864878, 864880, 855734, 855733, 28659, </team_members_id><team_members_names><![CDATA[Gordana Rubeša, Aristea Pavešić Radonja, Rozi Andretić Waldowski, Bobana Samardžija Samardžija, Maja Odorčić, Giovanna Dashi, Mihaela Bergman, Simone Ruhije Bertoša, Tina Fartek, Anja Hart, Beti Zaharija, ]]></team_members_names><keywords_hr><![CDATA[Shizofrenija, Mentalna bolest, Agregiranje proteina, Drosophila, Neuroznanost]]></keywords_hr><keywords_en><![CDATA[Schizophrenia, Mental illness, Protein Aggregation, Drosophila, Neuroscience]]></keywords_en><summary_hr><![CDATA[Schizofrenija, bipolarni poremećaj i teška depresija su devastirajuće mentalne bolesti s jako kompliciranom genetskom pozadinom. U cilju izbjegavanja složenosti genetike, predlažemo istraživanje izravno na proteinima uključenim u staničnu patologiju. Inspiraciju smo dobili zahvaljujući spoznajama neurodegenerativnih bolesti, kao što su Alzheimerova i Parkinsonova bolest, u kojima specifični proteini formiraju netopive krivo smotane agregate u mozgu. Radna hipoteza je da poremećena proteostaza može također biti razlog kroničnim mentalnim bolestima. Rezultati istraživanja upućuju na pet proteina koji potencijalno formiraju netopive agregate u mozgu dijela pacijenata s teškim mentalnim bolestima. To su: CRMP1. DISC1, dysbindin-1, NPAS3 and TRIOBP-1. Do danas nije poznato da li ovi proteini agregiraju zajedno ili imaju kumulativni efekt u istom pacijentu.Predloženi projekt ima za cilj integrativni pristup istraživanju agregacije ovih pet proteina. Biti će određena regija neophodna za agregaciju i iskorištena za sintezu mutiranih formi koje imaju ili nemaju sposobnost stvaranja agregata. Potom će divlji tip i mutant protein biti analizirani u cilju određivanja posljedice agregacije, bilo zasebno ili u kombinaciji. Istraživat će se na neuronima sličnim staničnim kulturama da se odrede posljedice agregata na razvoj, i također na transgenoj vinskoj mušici - Drosophila u cilju testiranja utjecaja na ponašanje.Eksperimente koje predlažemo, u budućnosti mogu poslužiti za analizu proteinskih agregata mentalnih bolesti u kompleksnijim trensgenim modelima. Također će omogućiti važne spoznaje o mogućoj uporabi agregata kao dijagnostičkih biomarkera i meta budućim terapeutskim intervencijama.]]></summary_hr><summary_en><![CDATA[Schizophrenia, bipolar disorder and major depression are devastating mental illnesses with a highly complicated genetic background. In order to circumvent this, we have proposed studying directly proteins involved in their cellular pathology. Specifically, we have taken inspiration from neurodegenerative conditions, such as Alzheimer&#39;s disease or Parkinson&#39;s disease, in which specific proteins form insoluble misfolded aggregates in the brain. We therefore hypothesised that disrupted proteostasis may also be a component of chronic mental illness. Data now exists implicating five proteins as potentially forming insoluble aggregates in the brains of subsets of patients with major mental illness: CRMP1, DISC1, dysbindin-1, NPAS3 and TRIOBP-1. To date however, it is not clear whether these proteins aggregate together or have cumulative effects on the same patients.The project proposed here therefore aims to take an integrative approach to studying the aggregation of these five proteins. The regions of these proteins required for aggregation will be determined and used to design mutant forms of them which either have or lack the ability to form aggregates. These wild-type and mutant proteins will then be investigated, in order to determine the consequences of aggregation of the proteins, both individually and in combination. This will be performed both in neuronal-like cell culture systems, in order to determine the consequences of aggregation on development, and also in transgenic Drosophila fruit flies in order to test their effects on behaviour.The experiments proposed here will aid in the design of more complex transgenic models of proteins aggregation in mental illness. They will also provide important insight into the potential value of such aggregates both as diagnostic biomarkers and as targets for future therapeutic interventions.]]></summary_en></project><project>
<id>7091</id><title_hr><![CDATA[Istraživanje i razvoj novih mikro i nanostrukturnih bioaktivnih materijala u dentalnoj medicini]]></title_hr><title_en><![CDATA[Investigation and Development of New Micro and Nanostructural Bioactive Materials in Dental Medicine]]></title_en><user_id>12362</user_id><user_firstLast_name>Ivana Miletić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-1719</code><acronim><![CDATA[BIODENTMED]]></acronim><duration>08.11.2018 - 07.11.2022</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Dentalna medicina, Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Dental medicine, Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Stomatološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Dentistry]]></institution_en><team_members_id>23313, 23312, 23320, 6401, 23315, 23323, 23317, 23316, 23310, 7026, 23344, 23340, 23341, 23365, 23355, 23354, 23357, 858408, </team_members_id><team_members_names><![CDATA[Silvana Jukić Krmek, Senka Meštrović, Hrvoje  Jurić, Željko Verzak, Anja Baraba, Jurica Matijević, Samir Čimić, Ana Ivanišević, Valentina Rajić, Zdravko Schauperl, Tanja Jurčević Lulić, Gorana Baršić, Jasna Leder Horina, Maja Bilić Prcić, Petra Bučević Sojčić, Marko Rajda, Marina Šimunović Aničić, Ivan Šalinović, ]]></team_members_names><keywords_hr><![CDATA[bioaktivnost, staklenoionomeri, kalcij silikatni cementi, vlakna, nanočestice, mikro CT, metoda konačnih elemenata]]></keywords_hr><keywords_en><![CDATA[bioactivity, glass-ionomers, calcium silicate cements, fibers, nanofillers, micro CT, finite element method]]></keywords_en><summary_hr><![CDATA[Svrha projekta je interdisciplinarno ispitivanje i poboljšanje svojstava bioaktivnih materijala koji se primjenjuju u različitim granama dentalne medicine. Prvi dio istraživanja usmjeren je na bioaktivne staklenoionomerne cemente. Ti materijali ostvaruju kemijsku vezu s površinom zuba, imaju remineralizirajući i kariostatski učinak. Međutim, njihovi nedostatci su još uvijek slaba fizičko-mehanička svojstva. Prvi cilj ovog projekta je istražiti mogućnost njihova poboljšanja dodavanjem staklenih vlakana i nanočestica u različitim omjerima te ispitati njihovu čvrstoću, tvrdoću, modul elastičnosti, remineralizacijski potencijal i adhezivnost na površinu zuba. U drugom dijelu istraživanja provest će se analiza biokeramike kao predstavnika novog bioaktivnog materijala za punjenje korijenskih kanala. Biokeramika bi trebala djelovati stimulativno na vitalno tkivo parodonta i dobro brtviti korijenski kanal. Stoga je drugi cilj projekta procijeniti odnos biokeramičkih materijala i strukture zuba u endodontskom prostoru ispitivanjem kvalitete brtvljenja ispuna korijenskog kanala biokeramikom prije i nakon dinamičkog opterećenja te mogućnost uklanjanja biokeramičkih materijala nakon revizije mikro CT analizom. Dinamičkim opterećenjem  nastoje se postići uvjeti slični onima u stomatognatom sustavu što je potrebno za ispravnu procjenu ponašanja materijala u kliničkim uvjetima. Temeljem podataka dobivenih laboratorijski i metodom konačnih elemenata odredit će se biomehanička i biomimetička svojstva istraživanih materijala. Originalnost predloženog istraživanja očituje se u sveobuhvatnom ispitivanju bioaktivnih materijala i doprinijet će boljem razumijevanju njihove strukture i svojstava te omogućiti razvoj poboljšanih protokola njihove kliničke primjene. Također, rezultati analize različitih ojačanja biomaterijala usmjerit će istraživanja prema njihovom daljnjem razvoju.]]></summary_hr><summary_en><![CDATA[The aim of the project is an interdisciplinary investigation and the enhancement of properties of bioactive materials properties used in different fields of dental medicine. The first part of the research is focused on bioactive glassionomer cements.  These materials chemically bond to the tooth surface and have a remineralizing and cariostatic effect. However, their disadvantages are poor physico-mechanical properties. The first aim of this project is to investigate the possibility of enhancing glassionomers by adding fibers and nanoparticles in different ratios and to assess the strength, hardness, modulus of elasticity, remineralizing potential and adhesion to the tooth surface.  Subsequently, the project will be focused on investigation of bioceramics as a representative of a new bioactive material for root canal filling. Bioceramics should stimulate the vital periodontal tissue and provide a good seal. Therefore, the second aim of the project is to assess the relation of bioceramic materials and tooth structure in the endodontic system by investigating the sealing ability before and after dynamic loading and the possibilities of the removal of bioceramics using micro CT. With dynamic loading, we are attempting to recreate the conditions similar to those in oral cavity which is necessary to correctly assess the behaviour of the materials under clinical conditions. With the data obtained in the laboratory and by finite element method biomechanical and biomimetic properties of the investigated materials will be determined. The originality of the proposed research lies in the detailed assessment of bioactive materials which should result in the better understanding of its structure and properties. It should also enable the development of better protocols for clinical application of the materials. Furthermore, the results of the analysis of different reinforcements of biomaterials will direct research towards enabling the materials to evolve even further.]]></summary_en></project><project>
<id>7092</id><title_hr><![CDATA[Kvantificiranje neodređenosti u formalizmu nuklearnih energijskih funkcionala gustoće ]]></title_hr><title_en><![CDATA[Uncertainty quantification within the nuclear energy density functional framework]]></title_en><user_id>780</user_id><user_firstLast_name>Tamara Nikšić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-5987</code><acronim><![CDATA[NucEDF]]></acronim><duration>01.10.2018 - 30.09.2022</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>12567, 19023, 23616, 11296, 25816, </team_members_id><team_members_names><![CDATA[Tomislav Marketin, Kosuke Nomura, Luka Gulin, Nils Paar, Giacomo Accorto, ]]></team_members_names><keywords_hr><![CDATA[Nuklearni energijski funkcionali gustoće, strukutra atomske jezgre, kolektivni modeli, fisija, Bayesian analiza]]></keywords_hr><keywords_en><![CDATA[Nuclear energy density functionals, structure of atomic nucleus, collective models, fission, Bayesian analysis]]></keywords_en><summary_hr><![CDATA[Opći cilj projekta NucEDF je razvoj i primjena inovativnog nuklearnog energijskog funkcionala gustoće koji bi osigurao precizna i pouzdana predviđanja svojstava osnovnog stanja i kolektivnih pobuđenja pokrivajući pritom cijelu kartu nuklida.Tijekom projekta ćemo formulirati i implementirati teorijski formalizam ne-empirijskih funkcionala kroz sljedeće specifične ciljeve: i) razvoj sljedeće generacije nuklearnih energijskih funkcionala gustoće zasnovanih na relativističkim nukleon-nukleon interakcijama izvedenim pomoću kovarijantne kiralne efektivne teorije polja, ii) razvoj sveobuhvatne baze podataka sa svojstvima osnovnog stanja i kolektivnih pobuđenja atomskih jezgri, iii) procjena primjenjivosti tehnika funkcionalne renormalizacijske grupe u razvoju nuklearnih energijskih funkcionala gustoće, iv) primjena Bayes-ovih metoda u analizi teorijskih neodređenosti raznih opservabli, v) unapređenje opisa procesa inducirane fisije, vi) unapređenje opisa procesa spontane fisije. Koristeći statističke metode i tehnike naprednog računarstva procijenit ćemo stabilnost i međusobne korelacije parametara nuklearnog energijskog funkcionala gustoće, izračunati neodređenost parametara i posljedičnu neodređenost izračunatih opservabli te ih uključiti u bazu podataka nuklearnih svojstava. Istražit ćemo utjecaj različitih stupnjeva slobode na proces fisije i izračunati distribucije fisionih fragmenata. Očekujemo da će projekt NucEDF pozitivno utjecati ne samo na zajednicu teorijskih nuklearnih fizičara, nego i na eksperimentalne nuklearne fizičare pružajući podršku postojećim i planiranim eksperimentalnim programima. Planirane aktivnosti će također ojačati kapacitete NucEDF projektnog tima u području naprednog računarstva.]]></summary_hr><summary_en><![CDATA[The project NucEDF will develop and apply novel nuclear energy density functional (EDF) capable to provide accurate and reliable predictions for the nuclear ground state properties and collective excitations over the entire nuclear chart. We will formulate and implement a framework for the non-empirical nuclear EDFs  with specific objectives: i) to develop the next generation  nuclear EDF  based on relativistic nucleon-nucleon interactions derived using covariant chiral effective field theory, ii) to develop comprehensive database containing nuclear ground state properties and collective excitations over the entire nuclear chart, iii) to assess the applicability of the functional renormalization group techniques in constructing the nuclear EDF, iv) to apply the Bayesian inference methods in an analysis of theoretical statistical uncertainties for various observables calculated with the newly developed EDF, v) to improve the description of the induced fission process within the EDF framework, vi) to improve the description of the spontaneous fission process within the EDF framework. Using statistical methods and advanced computing techniques, the stability and interdependence of the EDF parameters, the inherent parameter uncertainties and their propagation, and the corresponding uncertainties of predicted observables will be calculated and included in the developed database. Influence of various degrees of freedom on the fission process will be studied and the resulting distributions for the fission fragment yields will be calculated. The expected impact of the NucEDF project will influence not only the theoretical, but also the experimental nuclear physics community by providing support for the existing and planned experimental programmes. The planned activities will also strengthen the capacities of the NucEDF project team in the area of high-performance computing.  ]]></summary_en></project><project>
<id>7098</id><title_hr><![CDATA[Moderne misleće žene: Intelektualni razvoj žena u Hrvatskoj 20. stoljeća]]></title_hr><title_en><![CDATA[Modern Women Thinkers: Intellectual Development of Women in the 20th century Croatia]]></title_en><user_id>23254</user_id><user_firstLast_name>Andrea Feldman</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-3732</code><acronim><![CDATA[MMŽ/MWT]]></acronim><duration>01.10.2018 - 30.09.2022</duration><status>Završio</status><financ_value>50.036,50 eur</financ_value><scie_area_hr>Interdiciplinarne znanosti, Humanističke znanosti, Društvene znanosti, </scie_area_hr><scie_area_en>Interdisciplinary scientific area, Humanities, Social sciences, </scie_area_en><scie_field_hr>Povijest, Politologija, Sociologija, Filologija, Etnologija i antropologija, Obrazovne znanosti, Rodni studiji, </scie_field_hr><scie_field_en>History, Political Science, Sociology, Philology, Ethnology and anthropology, Educational sciences, Gender Studies, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Učiteljski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Teacher Education]]></institution_en><team_members_id>23255, 19116, 23270, 17872, 23529, 23774, 23668, </team_members_id><team_members_names><![CDATA[Marijana Kardum, Ida Ograjšek Gorenjak, Peto Andrea, Ana Batinić, Marci Shore, Tiina Kinnunen, Alenka Jensterle Doležal, ]]></team_members_names><keywords_hr><![CDATA[žene, intelektualna povijest, Hrvatska, kultura, obrazovanje, XX stoljeće ]]></keywords_hr><keywords_en><![CDATA[women, intellectual history, Croatia, culture, education, XX century]]></keywords_en><summary_hr><![CDATA[Projekt će se baviti konstrukcijom ženske intelektualne historije u Hrvatskoj, i identificirati idejne promjene u shvaćanju koncepta žene u 20. stoljeću kako bi se objasnila intelektualna ishodišta shvaćanja moderne žene. Pratit će se razvoj ideja koje su oblikovale prvenstveno žene vlastitim intelektualnim djelovanjem, utjecajem i kritikom mijenjajući tako društveni položaj žene i definiranjem kategorije intelektualca/ke. Istraživački fokus projekta smješten je u hrvatski te širi jugoslavenski i srednjeeuropski prostor od kraja 19. stoljeća do kraja 20. stoljeća. Razdoblje je to od pojave većeg sudjelovanja žena u društvenome i javnome životu s nakanom stjecanja potpune zakonske ravnopravnosti. Interdisciplinarno istraživanje obuhvatit će teorijske i prakseološke uvide iz historiografije, obrazovanja, teorije književnosti, antropologije, filozofije korištenjem domaće i strane literature i arhivske građe u nekoliko zemalja. Projekt će se baviti mehanizmima konstrukcije (nacionalnih, vjerskih, rodnih, klasnih, kulturnih) kolektivnih i individualnih identiteta ženske polovice stanovništva svih političkih uređenja na hrvatskom prostoru u vremenskom razdoblju od više od stoljeća. Ponudit će se kompleksnije razumijevanje utjecaja strukturnih promjena usred velikih društvenih, gospodarskih, kulturnih i političkih događaja promatranoga razdoblja. Projekt će istražiti osobe i ideje koje su kreirale promjene u razumijevanju (položaja) žene proučavanjem oblika i načina njihova društvenoga organiziranja i javnoga djelovanja (ženske organizacije, intelektualke: književnice, novinarke, učiteljice, profesorice, liječnice, umjetnice, znanstvenice, pripadnice društvene elite). Izrazita pozornost projekta usmjerena je neobjavljenoj i neistraženoj arhivskoj građi te nekonvencionalnim povijesnim izvorima javne i privatne provenijencije. ]]></summary_hr><summary_en><![CDATA[Project’s purpose is to construct intellectual history of women in Croatia and to detect ideological change in understanding of concept of woman in the first half of the 20th century. It will explain intellectual origins of modern woman in the context of changing social circumstances. It will trace development of ideas formulated by women in their intellectual endeavors, with their influence and criticism, changing their social position and defining the categories of intellectuals. The research is focused on Croat, Yugoslav and Central European space from the last decades of the 19th century to the end of the WWII. That period saw more active involvement of women in social and public life with an aim of achieving political and legal equality of women. The interdisciplinary research will encompass theoretical and practical insights in fields as diverse as history, education, literary theory, anthropology, philosophy.  International and domestic literature will be consulted, as well as archival sources in several countries. Project will reveal the mechanisms of construction of complex women&#39;s identities (both individual and collective) with reference to their national, religious, gender, class and cultural components. The aim is to understand life of women, during different political systems that reigned in this area through more than 50 years. Research will offer a complex understanding of structural changes that took place amidst great economic, social, cultural and political commotion. It will encompass personalities and ideas that created change in understanding of the status of women by study of the ways and forms of their social organizations and public actions (women&#39;s organizations, intellectuals, journalists, schoolteachers, professors, medical doctors, artists, scientists and members of society&#39;s elites). Focused on hitherto unpublished archival sources, the research will consult unconventional historical sources of public and private origins.]]></summary_en></project><project>
<id>7106</id><title_hr><![CDATA[Hrvatski renesansni aristotelizam: nova era u mišljenju prošlosti]]></title_hr><title_en><![CDATA[Croatian Renaissance Aristotelianism: New Era in Thinking the Past ]]></title_en><user_id>1441</user_id><user_firstLast_name>Pavel Gregorić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-4966</code><acronim><![CDATA[CRANEtp]]></acronim><duration>01.12.2018 - 30.05.2023</duration><status>Završio</status><financ_value>66.812,40 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filozofija, Filologija, </scie_field_hr><scie_field_en>Philosophy, Philology, </scie_field_en><institution_hr><![CDATA[Institut za filozofiju]]></institution_hr><institution_en><![CDATA[Institute for Philosophy in Zagreb]]></institution_en><team_members_id>3931, 4860, 23272, 2634, 7132, </team_members_id><team_members_names><![CDATA[Gorana Stepanić, Šime Demo, Martino Rossi Monti, Ivana Skuhala Karasman, Dora Ivanisevic, ]]></team_members_names><keywords_hr><![CDATA[Aristotel, renesansa, Dubrovnik, filozofija, znanost]]></keywords_hr><keywords_en><![CDATA[Aristotle, Renaissance, Dubrovnik, philosophy, science]]></keywords_en><summary_hr><![CDATA[Za istraživanje hrvatskog renesansnog aristotelizma odabran je reprezentativni uzorak koji čine tri autora: Antun Medo (Dubrovnik, 1530 - Dubrovnik, 1600?), Nikola Vitov Gučetić (Dubrovnik, 1549 - Dubrovnik, 1610) and Matija Frkić (Krk, 1583 - Padova, 1669). Istraživanje će se fokusirati na šest djela navedenih autora: dva komentara Antuna Mede, tri komentara Nikole Vitova Gučetića i jednu aristotelovsku raspravu Matije Frkića. Tih šest djela pokrivaju polja logike, prirodne filozofije, psihologije, retorike i metafizike.         Osnovni ciljevi predloženoga projekta su (i) utvrditi i procijeniti glavne značajke i novíne hrvatskog renesansnog aristotelizma; (ii) prosuditi filozofsku relevantnost hrvatskog renesansnog aristotelizma; (iii) istražiti jezične specifičnosti hrvatskog renesansnog aristotelizma; (iv) prosuditi povijesnu i kulturnu relevantnost hrvatskog renesansnog aristotelizma; (v) dati stručnoj i široj javnosti hrvatske prijevode integralnih djela hrvatskog renesansnog aristotelizma, ali i temeljna djela antičkih autora koja su hrvatski renesansni aristotelovci tumačili.	Ovo je multidisciplinarno i interdisciplinarno istraživanje na raskrižju filozofije, filologije, povijesti ideja i kulturne povijesti, što se jasno ogleda u ekspertizama okupljenih suradnika na projektu. U različitim etapama istraživanja, i za različite ciljeve, koristit će se standardne filozofske, filološke i lingvističke metode.	Očekivani rezultati uključuju 5 uredničkih knjiga, 8 izvornih ili preglednih znanstvenih članaka (od kojih barem 4 u uglednim inozemnim časopisima), jedna međunarodna konferencija, 3 međunarodne radionice, desetak izlaganja rezultata ovog istraživačkog projekta na domaćim i inozemnim skupovima, jedan skup s izložbom prigodom 350. obljetnice smrti Matije Frkića (2019.). ]]></summary_hr><summary_en><![CDATA[For the purpose of our research on Croatian Renaissance Aristotelianism, a representative sample of three authors has been selected: Antun Medo (Dubrovnik, 1530 - Dubrovnik, 1600?), Nikola Vitov Gučetić (Dubrovnik, 1549 - Dubrovnik, 1610) and Matija Frkić (Krk, 1583 - Padova, 1669). The research will focus on six works by these authors: two commentaries by Antun Medo, three commentaries by Nikola Vitov Gučetić and one Aristotelian treatise by Matija Frkić. These six works cover the fields of logic, natural philosophy, psychology, rhetoric and metaphysics.      The basic research objectives of the proposed project are: (i) to identify and evaluate the main features and possible novelties of Croatian Renaissance Aristotelianism; (ii) to evaluate the philosophical relevance of Croatian Renaissance Aristotelianism; (iii) to explore the linguistic specificities of Croatian Renaissance Aristotelianism; (iv) to evaluate the historical and cultural relevance of Croatian Renaissance Aristotelianism; (v) to provide academic and wider Croatian public with translations of integral works of Croatian Renaissance Aristotelianism, as well as the fundamental works of ancient philosophers interpreted by Croatian Renaissance Aristotelian authors.      This is a multidisciplinary and interdisciplinary research at the intersection of philosophy, philology, history of ideas and cultural history, as reflected in the expertise of the team&#39;s collaborators. At different stages of the research, and for different purposes, the standard methods of philosophy, philology and linguistics will be used.      The expected results include 5 books, 8 research or overview articles (of which at least 4 in reputed international journals), one international conference, three international workshops, presentations of the results of this research project at conferences in Croatia and abroad, and a symposium and exhibition on the occasion of the 350th anniversary of Matija Frkić&#39;s death (2019).]]></summary_en></project><project>
<id>7109</id><title_hr><![CDATA[Novi spojevi temeljeni na bioizosterima purina za ispitivanje njihovih antitumorskih i antipatogenih djelovanja]]></title_hr><title_en><![CDATA[Novel purine bioisostere-based compounds for their anticancer and antipathogenic activity evaluations]]></title_en><user_id>76</user_id><user_firstLast_name>Silvana Raić-Malić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-4682</code><acronim><![CDATA[PurBioCaPa]]></acronim><duration>01.12.2018 - 30.11.2022</duration><status>Završio</status><financ_value>132.483,91 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet kemijskog inženjerstva i tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Chemical Engineering and Technology]]></institution_en><team_members_id>22656, 1135, 3913, 2767, 13235, 6203, 17839, 23311, 3924, 23649, 28746, 861758, 22852, 864999, </team_members_id><team_members_names><![CDATA[Anja Harej, Andrijana Meščić, Silvija Maračić, Krešimir Pavelić, Ivana Stolić, Domagoj Drenjančević, Andrea Bistrović, John Kelly, Tatjana Gazivoda Kraljević, Sanja Kostrun, Valentina Rep, Anja Rakas, Željka Peršurić, Ivana Sokol, ]]></team_members_names><keywords_hr><![CDATA[purinski bioizosteri, benzimidazol, benzotiazol, 1,2,3-triazol, antitumorska, antibakterijska, antitripanosomska aktivnost]]></keywords_hr><keywords_en><![CDATA[purine bioisosteres, benzimidazole, benzothiazole, 1,2,3-triazole, anticancer, antibacterial, antitrypanosomal activity]]></keywords_en><summary_hr><![CDATA[S ciljem razvoja novih kemijskih entiteta sa snažnim i selektivnim antitumorskim, antibakterijskim i antitripanosomskim učinkom, predlažemo dizajniranje i sintezu novih purinomimetika primjenom strategije dizajniranja lijekova, poput bioizosterije i izmjene skeleta kod kojih se atomi dušika u aromatskom prstenu zamjenjuju atomom ugljika ili drugim heteroatomom. Derivati strukturno srodni purinima povezat će se s drugom farmakofornom jedinicom preko različitih premosnica kako bi se odredio njihov utjecaj na interakciju s molekulskom metom, a time i na biološku aktivnost. Radi ispitivanja moguće prednosti održivih sintetskih metoda u odnosu na tradicionalni pristup, uz klasične će se sintetske metode izabranih reakcija provesti i nekonvencionalne, poput mehanokemijskih i protočnih reakcija provedenih u mikroreaktoru. Kako bi se ostvario cilj predloženog projekta, nužno je koordinirano provođenje sinteze i optimiranje struktura, zajedno s metodama dizajniranja spojeva i ispitivanja njihovih bioloških djelovanja. Potom će se provesti antipatogena i citostatska ispitivanja s posebnim naglaskom na dodatna ispitivanja novopripravljenih spojeva na izabrane kemorezistentne tumorske stanične linije i bakterijske kliničke sojeve koji su rezistentni na postojeće antibiotike. Nadalje, za najdjelotvornije spojeve provest će se istraživanja molekulskog mehanizma djelovanja usmjerena na polinukleotide (DNA/RNA), odnosno enzime odabrane analizom in silico. Na temelju rezultata bioloških ispitivanja, ciljanim će se strukturnim modifikacijama optimirati strukture odabranih spojeva kandidata u svrhu poboljšanja njihove biološke aktivnosti i ADMET svojstava. Očekujemo da će u konačnici projekt rezultirati novim predvodnim spojevima sa selektivnim i učinkovitim antipatogenim, odnosno citostatskim djelovanjem, koji neće biti toksični, i koji će zadovoljiti potrebne kriterije za sljedeću fazu optimiranja predvodnog spoja.]]></summary_hr><summary_en><![CDATA[With the aim to develop new chemical entities with marked and selective anticancer, antibacterial and antitrypanosomal activity, we propose the design and synthesis of novel purinomimetics using the bioisosterism and scaffold hop by swapping nitrogen atoms with carbon and other heteroatoms in an aromatic ring. Purine-related derivatives will be linked to another pharmacophoric unit through various linkers to assess their impact on molecular target interaction and thereby biological activity. To evaluate the benefit of sustainable synthetic method to traditional approach, batch-based syntheses of chosen reactions will be translated to non-conventional, such as mechanochemical and micro-flow processes. In order to accomplish the aim of the proposed project, the synthesis and structure optimization along with drug design tools and biological evaluations will be performed in a coordinated manner. Furthermore, antipathogenic and cytostatic evaluations of newly prepared compounds will be performed emphasizing the additional assays on selected chemoresistant cancer cell line and antibiotic-resistant bacteria clinical strains. The molecular mechanism studies of the most effective compounds targeting polynucleotides (DNA/RNA) or enzymes, indicated by in silico analysis, will be subsequently carried out. On the basis of results of biological evaluations, structure optimization by chemical modification of selected compound candidates will be performed to improve their biological potency and ADMET properties. Finally, we expect that new lead compounds with selective and pronounced antipathogenic and/or cytostatic activities with no toxicity will be identified and satisfy necessary criteria for further lead optimization phase. ]]></summary_en></project><project>
<id>7116</id><title_hr><![CDATA[EKONOMSKI SENTIMENT: STATISTIČKI, POLITIČKI, BIHEVIORALNI I MEDIJSKI ASPEKTI NJEGOVOG UTJECAJA NA EKONOMSKU AKTIVNOST]]></title_hr><title_en><![CDATA[ECONOMIC SENTIMENT: STATISTICAL, POLITICAL, BEHAVIORAL, AND MEDIA ASPECTS OF ITS INFLUENCE ON ECONOMIC ACTIVITY]]></title_en><user_id>4385</user_id><user_firstLast_name>Petar Sorić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-4189</code><acronim><![CDATA[EconSent]]></acronim><duration>01.11.2018 - 31.10.2022</duration><status>Završio</status><financ_value>50.524,92 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, Politologija, Psihologija, </scie_field_hr><scie_field_en>Economy, Political Science, Psychology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Ekonomski fakultet u Zagrebu]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Economics and Business]]></institution_en><team_members_id>21201, 4299, 23425, 3912, 6252, 6659, 26644, </team_members_id><team_members_names><![CDATA[Marina Matošec, Mirjana Čižmešija, Oscar Claveria, Blanka Škrabić Perić, Ivana Lolić, Andrija  Henjak, Marija  Logarušić, ]]></team_members_names><keywords_hr><![CDATA[ankete pouzdanja poduzeća i potrošača, bihevioralna ekonomija, indeks neizvjesnosti ekonomske politike, strojno učenje, analiza medijskih sadržaja]]></keywords_hr><keywords_en><![CDATA[Business and Consumer Surveys, Behavioral Economics, Economic Policy Uncertainty Index, Machine Learning, Media Content Analysis]]></keywords_en><summary_hr><![CDATA[Svjetska financijska kriza jasno je pokazala da ekonomski modeli ne mogu adekvatno objasniti ni prognozirati događaje poput gospodarskog pada 2008.g. Ekonomisti su na to odgovorili uvođenjem latentnih varijabli poput sentimenta u svoje analize. Ključnu ulogu u tim nastojanjima imale su ankete pouzdanja poduzeća i potrošača, bogate baze podataka o medijskim izvještajima te razna ispitivanja političkog sentimenta.Ciljevi ovog projekta (proizašli iz neophodne multidisciplinarnosti ekonomskog istraživanja) su:1) Identificirati uzročne veze između ekonomskog sentimenta, medijskih sadržaja, rezultata anketa o političkim preferencijama i ekonomske aktivnosti2) Testirati perzistentnost političkog i ekonomskog sentimenta među EU zemljama i po gospodarskim sektorima3) Analizirati stupanj sinkronizacije ciklusa ekonomskog sentimenta između perifernih zemalja i jezgre EU4) Testirati hipotezu „nove umjerenosti“ nakon krize 2008. na političkom i ekonomskom sentimentu u pojedinim članicama EU 5) Razviti indeks iznenađenja temeljenog na BCS podacima i primijeniti ga u kratkoročnom prognoziranju ekonomske aktivnosti u pojedinim članicama EU6) Generirati ekonomske indikatore temeljene na anketnim podacima o očekivanjima pomoću evolucijskog programiranja7) Modificirati metodologiju indeksa neizvjesnosti ekonomske politike korištenjem tehnika strojnog učenja u svrhu osnaživanja njegovih vodećih karakteristika (primjena na SAD i Hrvatsku)Ovaj projekt trebao bi doprinijeti podizanju svijesti ekonomista o nužnosti koherentnog multidisciplinarnog pristupa analizi makroekonomskih fenomena. Korištenje anketa o političkom mnijenju i podataka iz medijskih izvještaja može pripomoći našem razumijevanju kompleksnosti ekonomskih procesa, kao i njihove međupovezanosti s društvenim kretanjima (politikom i medijima). Također, očekuje se da će prodiranje metoda strojnog učenja u ekonomiju u cijelosti unaprijediti kvalitetu prognoziranja standardnih vodećih ekonomskih pokazatelja.]]></summary_hr><summary_en><![CDATA[The global financial crisis has vividly demonstrated that economic models are not able to adequately explain (or forecast) extreme events such as the economic downfall in 2008. Economists have responded by introducing latent variables (such as economic agents’ sentiment) in their analyses. The pivotal role in these efforts has been assigned to Business and Consumer Surveys (BCS), rich news media datasets, and various political opinion polls.The goals of this project (stemming from the much-needed multidisciplinarity of economic research) are to:1)	Identify causal links between economic sentiment, news media contents, political opinion poll results and economic activity2)	Test the persistence of political and economic sentiment across EU countries and economic sectors3)	Analyze the synchronization degree of economic sentiment cycles between peripheral and core EU countries 4)	Test the “new modesty” hypothesis after the 2008 crisis on political and economic sentiment in EU Member States 5)	Develop a BCS-based surprise index and apply it in short-term forecasting of economic activity in individual EU Member States6)	Generate data-driven economic indicators from survey expectations by means of evolutionary computation7)	Modify the methodology of Economic Policy Uncertainty (EPU) Index by utilizing machine learning techniques in order to strengthen its leading characteristics (applications to USA and Croatia)This project should contribute to raising economists’ awareness of the necessity of a coherent multidisciplinary approach to assessing macroeconomic phenomena. Utilizing political opinion polls and news reports datasets might add to our understanding of the complexity of economic processes, as well as of their interrelationships with other social developments (politics and the media). Likewise, the penetration of machine learning into economics is expected to raise the overall forecasting quality of standard economic leading indicators.]]></summary_en></project><project>
<id>7131</id><title_hr><![CDATA[Odgovori na antisocijalne osobnosti u demokratskom društvu ]]></title_hr><title_en><![CDATA[Responding to antisocial personalities in a democratic society]]></title_en><user_id>4121</user_id><user_firstLast_name>Luca Malatesti</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-3518</code><acronim><![CDATA[RAD]]></acronim><duration>15.10.2018 - 14.10.2022</duration><status>Završio</status><financ_value>75.311,02 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filozofija, Interdisciplinarne humanističke znanosti, </scie_field_hr><scie_field_en>Philosophy, Interdisciplinary humanities, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Filozofski fakultet u Rijeci]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>4172, 23385, 4815, 1453, 25808, 19830, 865224, </team_members_id><team_members_names><![CDATA[Marko Jurjako, Inti Angelo Brazil, John McMillan, Elvio Baccarini, Mia Biturajac, Ivan Cerovac, Mladen Bošnjak, ]]></team_members_names><keywords_hr><![CDATA[Neuroetika, psihijatrijska etika, antisocijalni poremećaj ličnosti, psihopatija, neuropsihologija, pučka psihologija, liječenje, moralno poboljšanje,]]></keywords_hr><keywords_en><![CDATA[Neuroethics, psychiatric ethics, antisocial personality disorder, psychopathy, treatment, moral enhancement, neuropsychology, folk psychology, ]]></keywords_en><summary_hr><![CDATA[Predloženi istraživački projekt istražit će etička pitanja koja se javljaju pri prevođenju i prenošenju znanstvenih spoznaja o antisocijalnim osobnostima na društvene prakse unutar demokratskog društva. Cilj je povezati ili sučeliti najznačajnije rezultate trenutno dostupnih znanstvenih spoznaja o antisocijalnom ponašanju s normativnim okvirom koji bi trebao potkrijepiti etičke preporuke o liječenju, intervenciji, poboljšanju i prevenciji kriminalaca i drugih osoba s tim poremećajima. U fokusu istraživanja se nalaze dva općenita i hitna teorijska izazova. Jedan je problem povezivanja ili sučeljavanja normativnog pojma osobe i njezinih kognitivnih moći i sposobnosti za odlučivanje sa znanstvenim koncepcijama i spoznajama o tim sposobnostima. Normativni pojam osobe se elaborira u filozofskim i pravnim teorijama kriminalne i moralne odgovornosti koje podrazumijevaju postojanje sposobnosti za racionalno odlučivanje i autonomiju. Drugi je problem artikuliranje normativnog okvira za primjenu na dva međusobno povezana normativna zadatka. Prvo, ovaj okvir mora dati formu opravdanja za pojam normativne osobe koji sam ne smije biti obilježen spornim metafizičkim gledištima već mora biti definiran u terminima koji su prihvatljivi unutar pluralističkog i demokratskog društva. Drugo, normativni okvir mora nas voditi prema praktičnim rješenjima o tome kako reagirati na pojedince s antisocijalnim poremećajima osobnosti, koja mogu biti prihvatljiva svim racionalnim članovima pluralističkog i demokratskog društva. ]]></summary_hr><summary_en><![CDATA[The proposed research project will investigate the ethical issues raised by translating scientific advances in the study of antisocial personalities to the social practices of a democratic society. The aim is to interface the most remarkable results of current science of antisocial behaviour with a normative framework that should underpin ethical recommendations on the treatment, intervention, enhancement and prevention that target offenders and other individuals with these disorders.Two general and pressing theoretical challenges will be at the core of the proposed investigation. One is the problem of interfacing the normative notion of a person and her cognitive and decision-making faculties with scientific conceptions of those faculties. The normative notion of a person is spelled out in philosophical and legal accounts of criminal and moral responsibility that presuppose having capacities for rational decision-making and autonomy. The other is the problem of articulating a normative framework for applying it to two interrelated normative tasks. First, this framework must inform the justification of a notion of the normative person that, being not hostage to metaphysically contestable views, is acceptable within a pluralistic democratic society. Second, it would guide our practical resolutions about how to respond to individuals with antisocial personalities that is viable in a pluralistic democratic society.]]></summary_en></project><project>
<id>7134</id><title_hr><![CDATA[Influence of redox status on psychostimulant-induced neural plasticity]]></title_hr><title_en><![CDATA[Utjecaj redoks stanja na neuralnu plastičnost izazvanu psihostimulansima]]></title_en><user_id>69</user_id><user_firstLast_name>Rozi Andretić Waldowski</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-2794</code><acronim><![CDATA[DrugPlast]]></acronim><duration>01.01.2019 - 31.12.2022</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci]]></institution_hr><institution_en><![CDATA[University of Rijeka]]></institution_en><team_members_id>20232, 23605, 5439, 8313, 4624, 28669, 855438, </team_members_id><team_members_names><![CDATA[Sanja Radman, Jorge Campusano, Ralph Greenspan, Rainer  Spanagel, Ana Filošević, Franka Rigo, Milan Petrović, ]]></team_members_names><keywords_hr><![CDATA[neuralna plastičnost, psihostimulansi, redoks, genetika, ponašanje, Drosophila]]></keywords_hr><keywords_en><![CDATA[neuronal plasticity, psychostimulants, redox, genetics, behavior, Drosophila]]></keywords_en><summary_hr><![CDATA[Opojne droge mijenjaju funkcije mozga i dovode do ovisnosti aktivirajući mehanizme neuralne plastičnosti. Drosophila melanogaster je do sada uspješno korištena kao model organizam za ispitivanje utjecaja opojnih droga na živčani sustav radi sličnosti na nivou gena, neurotransmitera i mehanizama kojima droge mijenjaju mozak.Naši preliminarni rezultati pokazuju da promjena redoks ravnoteže u Drosophile onemogućava razvoj lokomotorne senzitizacije na metamfetamin (METH) i kokain. Na osnovu tih otkrića predlažemo ispitati kako promijene u redoks ravnoteži utječu na neuralnu plastičnost izazvanu psihostimulansima. Naša hipoteza je da lokomotorna senzitizacija, kao oblik neuralne plastičnosti, ovisi o redoks stanju.Imamo tri glavna cilja:a) identificirati gene koji reguliraju redoks stanje i utječu na regulaciju lokomotorne senzitizacije na METH, b) identificirati u kojim dijelovima mozga je ekspresija gena koji reguliraju redoks stanje važna za regulaciju lokomotorne senzitizacije, i c) identificirati funkcionalne promijene na nivou otpuštanja biogenih amina, aktivacije antioksidativnih enzima i količine reaktivnih kisikovih vrsta koje su povezane s razvojem lokomotorne senzitizacije.Kako bi ostvarili te ciljeve koristiti ćemo niz komplementarnih pristupa koji će nam omogućiti da analiziramo neuralnu plastičnost na nivou ponašanja i genetike, transkriptomike, proteomike, elektrofiziologije i biokemije kako bi karakterizirali odgovorne gene i proteine.Ishodi ovoga projekta pridonijeti će razumijevanju osnovnih genetskih mehanizama koji su aktivirani opetovanom administracijom psihostimulansa. Očekujemo da će ishodi ovoga projekta pomoći u razumijevanju bazičnih principa neuralne plastičnosti općenito. Radi značajnog utjecaja redoks ravnoteže na stanične funkcije, naši rezultati mogu sugerirati jednostavne strategije za spriječavanje i tretman ovisnosti.]]></summary_hr><summary_en><![CDATA[Drugs of abuse change brain functioning and lead to addiction engaging mechanisms of neuronal plasticity. Drosophila melanogaster has successfully been used as a model organism to study action of addictive drugs on the nervous system because of the conservation at the levels of genes, neurotransmitters and mechanisms of change that drugs induce. Our preliminary data shows that in Drosophila the change in the redox balance interferes with the development of locomotor sensitization to methamphetamine (METH) and cocaine. Based on these findings we propose to investigate how do changes in the redox balance regulate drug-induced neuroplasticity. Our hypothesis is that locomotor sensitization, as one form of neuroplasticity, depends on redox status. We have three main objectives: a) to identify genes involved in redox regulation that affect development of locomotor sensitization to METH, b) to identify brain areas where expression of genes regulating redox balance is required for development of locomotor sensitization, and c) to identify functional changes at the level of the release of bigenic amines, activity of antioxidant enzymes and amount of reactive oxidative species that are correlated with development of locomotor sensitization. To achieve these objectives we will use number of different complementary approaches that will enable us to analyze neuronal plasticity at the level of behavior and genetics, transcriptomics, proteomics, electrophysiology and biochemistry to functionally characterize candidate genes and proteins.Outcomes of this study will contribute in the understanding of basic genetic mechanisms that are triggered with repeated administrations of psychostimulants. We expect that outcomes of this study will help in the understanding of basic principles of neuronal plasticity in general. Because of the wide influence of redox balance on cell functioning, our results may result in simple strategies for prevention and treatment of addiction.]]></summary_en></project><project>
<id>7147</id><title_hr><![CDATA[Razvoj održivog integriranog procesa proizvodnje biološki aktivnih izolata iz proizvodnih ostataka prehrambene industrije]]></title_hr><title_en><![CDATA[Development of a sustainable integrated process for the production of bioactive isolates from food industry residues]]></title_en><user_id>4070</user_id><user_firstLast_name>Ana  Bucić-Kojić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-1227</code><acronim><![CDATA[POPI-WinCEco]]></acronim><duration>31.10.2018 - 30.10.2022</duration><status>Završio</status><financ_value>132.237,04 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Prehrambena tehnologija, Interdisciplinarne biotehničke znanosti, </scie_field_hr><scie_field_en>Food technology, Interdisciplinary biotechnical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Prehrambeno-tehnološki fakultet]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Food Technology]]></institution_en><team_members_id>4717, 23326, 23393, 6811, 23651, 309, 1277, 25658, 856193, </team_members_id><team_members_names><![CDATA[Mirela Planinić, Gordana Šelo, Katarina Jukić, Daliborka Koceva Komlenić, Ana Šušak, Marina Tišma, Katarina Mišković Špoljarić, Josipa Grgić, Gabriela Perković, ]]></team_members_names><keywords_hr><![CDATA[proizvodni ostaci, biološki aktivni izolati, polifenoli, biološka obrada, ekstrakcija, sušenje, enkapsulacija, funkcionalni proizvod, bioraspoloživost]]></keywords_hr><keywords_en><![CDATA[food industry residues, bioactive isolates, polyphenols, biological treatment, extraction, drying, encapsulation, functional product, bioaccessibility]]></keywords_en><summary_hr><![CDATA[U prehrambenoj industriji zaostaju značajne količine proizvodnih ostataka (POPI) koji se uglavnom odbacuju iako po svom kemijskom sastavu imaju potencijal za daljnje korištenje u proizvodnji visokovrijednih produkata (npr. biološki aktivnih izolata bogatih polifenolnim spojevima, BAI). POPI biljnog porijekla su uglavnom teško razgradivi lignocelulozni materijali koji u svojoj strukturi sadrže inkorporirane polifenole, koji su zbog toga teško ekstraktibilni ili imaju nisku bioraspoloživost. Ekstrakcija teško topljivih polifenola zahtjeva dodatne postupke razgradnje (npr. kiselinama ili komercijalnim enzimima), koji povećavaju troškove proizvodnje i/ili nisu ekološki prihvatljivi. Fermentacija na čvrstim nosačima (solid-state fermentation, SSF) je bioproces koji ima veliki potencijal za pretvorbu otpada poljoprivredne i prehrambene proizvodnje u visokovrijedne produkte, među kojima su i BAI, na ekološki prihvatljiv način. Cilj ovog projekta je razviti održivi integrirani proces proizvodnje BAI-a iz POPI-a (trop grožđa; mekinje i pljevica žitarica) biljnog porijekla, pri čemu će se POPI prvo obraditi filamentoznim gljivama u SSF uvjetima, nakon čega će se koristiti za proizvodnju BAI a pomoću ekstrakcije otapalom. Razvit će se i protokoli stabilizacije BAI-a, primjenom suvremenih tehnologija (enkapsulacijom, sušenjem raspršivanjem, liofilizacijom), te će se odrediti antioksidacijska i antitumorska aktivnost BAI-a u in vitro uvjetima. Proizvedeni BAI koristiti će se kao dodaci u proizvodnji funkcionalnog keksa i srodnih proizvoda. Simuliranim procesom probave u in vitro uvjetima, ispitat će se bioraspoloživost polifenola iz BAI-a i funkcionalnog keksa. Rezultati predloženog projekta imat će pozitivne ekonomske i društvene utjecaje kroz razvoj ekološki prihvatljivog procesa proizvodnje BAI-a, minimiziranje količine otpada iz prehrambene industrije, povećanje dodane vrijednosti proizvoda, te indirektan utjecaj na ljudsko zdravlje kroz proizvodnju funkcionalnih proizvoda.]]></summary_hr><summary_en><![CDATA[There are significant amounts of residues from the food industry (POPI) which are usually discarded even though their chemical composition gives them the potential to be further used in the production of high-value products (e.g. biologically active polyphenol rich isolates, BAI). The POPI of plant origin are mostly lignocellulosic materials recalcitrant towards degradation, and incorporate polyphenolic compounds in its structure. Those polyphenolic compounds are difficult to be extracted, thus have low bioaccessibility. Extraction of low soluble polyphenols requires additional processes of degradation by e.g. acids or commercial enzymes, which increase the costs of production and/or are not environmentally friendly. Solid-state fermentation (SSF) has a great potential for conversion of agro-food industry residues into numerous high-value products, including BAI, in an environmentally friendly way. The goal of this project is to develop a sustainable integrated process for the production of BAI from POPI (grape pomace; bran and hull of cereals) where the POPI will be initially treated with filamentous fungi in SSF conditions. After the treatment it will be used for the production of BAI using solvent extraction. Protocols for the stabilization of BAI will be developed by using state-of-the-art technologies (spray drying, freeze-drying, encapsulation) and antioxidative and antitumor activity of BAI will be determined in in vitro conditions. Stable BAI will be used in the production of functional cookies and crackers. Through the simulated process of digestion in in vitro conditions, polyphenol bioaccessibility from the BAI and functional products will be tested. The results of the proposed project will have positive economic and social effects through development of environmentally friendly process for BAI production, minimization of food industry waste, increase of added product value, and indirect impact on human health through development of functional products.]]></summary_en></project><project>
<id>7156</id><title_hr><![CDATA[Kombinatorički objekti i kodovi]]></title_hr><title_en><![CDATA[Combinatorial objects and codes]]></title_en><user_id>885</user_id><user_firstLast_name>Dean Crnković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-6732</code><acronim><![CDATA[COCo]]></acronim><duration>01.01.2019 - 31.12.2022</duration><status>Završio</status><financ_value>130.068,35 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Fakultet za matematiku]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Mathematics]]></institution_en><team_members_id>919, 5381, 5935, 907, 4515, 4484, 1089, 3161, 3468, 3226, 23476, 23496, 4992, 23495, 23513, 17780, 28994, </team_members_id><team_members_names><![CDATA[Sanja Rukavina, Mario Osvin Pavčević, Vedran Krčadinac, Vedrana Mikulić Crnković, Andrea Švob, Anamari Nakić, Doris Dumičić Danilović, Marija Maksimović, Nina Mostarac, Marina Šimac, Sara Ban, Ivona Novak, Kristijan Tabak, Tin Zrinski, Matteo Mravić, Renata Vlahović, Daniel Hawtin, ]]></team_members_names><keywords_hr><![CDATA[kombinatorički dizajn, graf, Hadamardova matrica, konačna grupa, kod]]></keywords_hr><keywords_en><![CDATA[combinatorial design, graph, Hadamard matrix, finite group, code]]></keywords_en><summary_hr><![CDATA[U sklopu ovog projekta konstruirat će se i analizirati različiti tipovi kombinatoričkih dizajna i grafova. Kombinatoričke strukture konstruirat će se kombiniranjem računalnih, geometrijskih i algebarskih metoda. Proučavat će se i drugi kombinatorički objekti, kao što su binarni komplementarni nizovi (npr. periodični Golayjevi parovi) i Hadamardove matrice (uključujući kompleksne Hadamardove matrice). Također će se proučavati veza s drugim strukturama, na primjer s konačnim geometrijama i asocijacijskim shemama. Konačne grupe imat će značajnu ulogu u konstrukciji i analizi kombinatoričkih struktura. Nadalje, u sklopu projekta konstruirat će se i analizirati kodovi, posebno linearni kodovi dobiveni iz kombinatoričkih dizajna, grafova, binarnih nizova i Hadamardovih matrica. Kao rezultate predloženog istraživanja očekujemo konstrukcije i klasifikacije različitih tipova kombinatoričkih dizajna i grafova (npr. novih blokovnih dizajna i jako regularnih, odnosno distance regularnih, grafova) i drugih kombinatoričkih objekata (komplementarnih nizova, Hadamardovih matrica, itd.), kao i konstrukciju kodova s dobrim svojstvima (npr. linearnih kodova s velikom minimalnom udaljenošću s obzirom na duljinu i dimenziju koda, samodualnih kodova, itd.). Očekujemo da će rezultati ovog projekta biti zanimljivi znanstvenicima koji rade u području teorije dizajna, teorije kodiranja i teorije grafova, kao i onima koji se bave istraživanjima u području teorije konačnih grupa.  ]]></summary_hr><summary_en><![CDATA[This project deals with construction and analysis of various types of combinatorial designs and graphs. For construction of combinatorial structures we will combine computational, geometric and algebraic approach. We will also take into consideration other combinatorial objects, such as binary complementary sequences (e.g. periodic Golay pairs) and Hadamard matrices (including complex Hadamard matrices). Relations to other structures (finite geometries, association schemes, etc.) will also be taken into account. Finite groups actions will have a significant role in constructing and analysing combinatorial structures. Further, we will work on construction and analysis of codes, mostly linear codes that can be obtained from combinatorial designs, graphs, binary sequences and Hadamard matrices.As a result of the proposed research, we expect a construction and classification of various types of combinatorial designs and graphs (e.g. new block designs and strongly/distance regular graphs) and other combinatorial objects (complementary sequences, Hadamard matrices, etc.), as well as a construction of codes with good properties (e.g. linear codes with large minimum distance comparing to the length and the dimension of the code, self-dual codes, etc.). We expect that the outcomes of this project will be of interest for researchers working in design theory, coding theory and graph theory, and for those working in theory of finite groups.  ]]></summary_en></project><project>
<id>7157</id><title_hr><![CDATA[Utjecaj gospodarenja i klimatskih promjena na dinamiku rasta stabala i sastojina jele Dinarskog područja Hrvatske]]></title_hr><title_en><![CDATA[Influence of management and climate on Silver fir trees and stand growth dynamics in Croatian Dinarides]]></title_en><user_id>13792</user_id><user_firstLast_name>Jura Čavlović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-8820</code><acronim><![CDATA[FirGroDin]]></acronim><duration>01.11.2018 - 31.10.2022</duration><status>Završio</status><financ_value>127.821,36 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Šumarstvo, </scie_field_hr><scie_field_en>Forestry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet šumarstva i drvne tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Forestry and Wood Technology]]></institution_en><team_members_id>12737, 13518, 13572, 5728, 20509, 13381, 23555, 5743, 22673, </team_members_id><team_members_names><![CDATA[Mislav Vedriš, Tomislav Levanič, Ernest Goršić, Stjepan Posavec, Mario Božić, Krunoslav Teslak, Andrej Bončina, Karlo Beljan, Marijana Žunić, ]]></team_members_names><keywords_hr><![CDATA[razvoj sastojina, obična jela, režim gospodarenja, klimatske promjene, dendrokronologija, prirodne nepogode ]]></keywords_hr><keywords_en><![CDATA[Stand Development, Silver Fir, Management Regime, Climate Change, Dendrochronology, Natural Disasters]]></keywords_en><summary_hr><![CDATA[Uz jelove šume najčešće je vezan pristup prebornog gospodarenja koji je tip prirodi bliskog gospodarenja kao opći trend šumarstva Europe i svijeta, ali također uz jelu već je više godina povezan i pojam odumiranja šuma. Pokazatelji karakteristični za odumiranje stabala jele su gubitak vitalnosti, smanjeni rast i porast mortaliteta. Opće prihvaćena teorija o propadanju jele je povezanost između poremećaja u rastu i povećanog mortaliteta s onečišćenjem zraka (emisijama SO2) u kompleksnoj interakciji s klimatskim i biotskim faktorima, ali i postupcima gospodarenja. O potrebama za dugoročnim monitoringom šumskih ekosustava u uvjetima narušavanja njihove stabilnosti svjedoče brojni projekti i inicijative u Europi za sustavno praćenje ekološke stabilnosti, raznolikosti i prilagodbe šumskih ekosustava klimatskim promjenama. U Hrvatskoj nema primjera sveobuhvatnog i sustavnog istraživanja i praćenja šumskih ekosustava šireg prostora. Zbog navedenog značaja i promjena uslijed utjecaja gospodarenja i okolišnih čimbenika šuma jele Dinarskog područja na nacionalnoj i europskoj razini, ovaj projekt je predložen s ciljem uspostave i provedbe sveobuhvatnog sustava monitoringa i istraživanja šuma jele na cijelom području hrvatskih Dinarida. Na podlozi od 80 trajnih pokusnih ploha provelo bi se istraživanje i praćenje dugogodišnjeg i postojećeg utjecaja klimatskih i okolišnih čimbenika i režima gospodarenja na stanje i dinamiku stabala i sastojina jele. U sustav trajnih ploha koje pokrivaju gradijent klime, utjecaja onečišćenja i areala, te stanišne i gospodarske značajke na konzistentan način integriran je ograničeni uzorak ploha i stabala za detaljno praćenje i istraživanje. Razmjena rezultata i iskustava istraživane problematike te afirmacija istraživačke skupine i posljedično uključivanje u istraživačke projekte na međunacionalnoj razini krajnji je očekivani rezultat ovog projekta.]]></summary_hr><summary_en><![CDATA[Silver fir forests are nowadays mostly associated with selection forest management approach, being a type of close to nature forest management that is a general trend of European and world forestry. Other characteristic of fir forest is the forest decline. Impaired fir trees are typically characterized by loss of vitality, growth reduction and higher mortality. The most recent and widely accepted hypothesis of silver fir decline is that the growth decrease and higher mortality rate in the second half of twentieth century, along with its recovery afterwards, were linked to air pollution (SO2 emissions) in interaction with climatic and biotic factors, and also management approaches. Numerous projects and incentives in Europe on systematic monitoring of ecological stability, biodiversity and adaptation of forest ecosystems to climate changes indicate needs for long-term monitoring of forest ecosystems of disturbed stability. In Croatia, there are almost no examples of systematic monitoring and research of forest ecosystems on landscape level. Based on evidenced importance and caused changes of the silver fir-beech Dinaric forests on national and Europe level, this project is proposed in order to establish and conduct consistent monitoring and research silver fir forests within entire Dinaric region of Croatia. Research will be based on 80 permanent plots for monitoring of past and current influences of climatic and environmental factors and management regimes on current state and dynamics of silver fir trees and stands. The system of permanent plots covering gradient of climate, air emission and spread, site and management characteristics will include plots and trees for detailed and intensive measurements. The exchange of results and experience, and affirmation of the project research group with consequential integration in research projects on international level are expected results of this project.]]></summary_en></project><project>
<id>7159</id><title_hr><![CDATA[Oklapanje od elektromagnetskih polja električki vodljivim tekstilnim materijalima]]></title_hr><title_en><![CDATA[Shielding from electromagnetic fields with electrically conductive textile materials ]]></title_en><user_id>19352</user_id><user_firstLast_name>Krešimir Malarić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-7028</code><acronim><![CDATA[SEMECTEX]]></acronim><duration>01.12.2018 - 30.11.2022</duration><status>Završio</status><financ_value>128.626,45 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, Tekstilna tehnologija, </scie_field_hr><scie_field_en>Electrical engineering, Textile technology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>5841, 328, 13106, 6949, </team_members_id><team_members_names><![CDATA[Tanja Pušić, Martin Dadić, Bosiljka Šaravanja, Damir Muha, ]]></team_members_names><keywords_hr><![CDATA[elektromagnetska polja, tekstilni materijali, učinkovitost oklopa, elektromagnetsko zračenje, zaštita od elektromagnetskih polja]]></keywords_hr><keywords_en><![CDATA[electromagnetic fields, textile materials, shielding effectiveness, electromagnetic radiation, electromagnetic field protection ]]></keywords_en><summary_hr><![CDATA[Elektromagnetsko polje na mikrovalnim frekvencijama nalazi se svuda oko nas: mobilni telefoni, Wi-Fi, tableti, mikrovalne pećnice, itd... Današnji način života zahtjeva od ljudi kontinuiranu uporabu sve više i više elektroničkih uređaja. Najveći broj odašiljača radi na frekvencijama između 900 MHz i 2,4 GHz. To uključuje GSM telefone i bazne postaje (900 MHz i 1800 MHz) te Wi-Fi (2,4 GHz). Dok s jedne strane većina ljudi ne želi u blizini imati bazne postaje GSM-a, gotovo nitko se ne želi lišiti mogućnosti koje pruža pokretni telefon ili tablet. Danas se sve više ljudi želi zaštiti od elektromagnetskog polja. Potpuna zaštita od elektromagnetskog polja na mikrovalnim frekvencijama je nemoguća. Ona bi uključivala neku vrstu Faradayevog kaveza, ali tada komunikacija ne bi bila moguća, tj. elektromagnetski signal ne bi mogao doprijeti od odašiljača do prijamnika. Elektromagnetsko oklapanje jedna je mogućnost zaštite od elektromagnetskog zračenja. Kod ljudi, ta zaštita može biti u vodljivim tekstilnim materijalima koji se ugrađuju u odijela ili kape. Vodljivi materijali mogu se ugrađivati i u tapete ili zavjese radi zaštite od vanjskih elektromagnetskih polja. Danas na tržištu postoje tekstilni materijali s metalnim nitima uglavnom od srebra ili bakra. Ti materijali su vrlo lagani ali dosta skupi. Cilj predloženog istraživanja je analiza postojećih tekstilnih materijala s vodljivim nitima od srebra i bakra za elektromagnetsko oklapanje. Tijekom istraživanja na projektu razvile bi se metode mjerenja učinkovitosti vodljivih tekstilnih oklopa na frekvencijama od 900 MHz do 2,4 GHz, te mogućnost njihove primjene kod zaštite ljudi. Ispitala bi se i trajnost, odnosno životni ciklus vodljivih tekstilnih materijala tijekom uporabe i njege.  ]]></summary_hr><summary_en><![CDATA[Electromagnetic fields on microwave frequencies are present everywhere around us: mobile phones, W-Fi, tablets, microwave owens, etc. Today way of living demands from people continuous use of many electronic devices. The large number of transmitters nowadays works on frequencies between 900 MHz and 2.4 GHz. This includes GSM phones and base stations (900 MHz and 1800 MHz) and Wi-Fi (2.4 GHz). While on one hand most people do not want to live in vicinity of GSM base station, almost nobody wants to deprive himself from the advantages offered by mobile phone or tablet. Today, more and more people want to protect themselves from the electromagnetic field radiation. Complete protection from the electromagnetic fields on microwave frequencies is impossible. It would include some sort of Faraday cage, but then the communication would not be possible, that is; electromagnetic signal could not travel from transmitter to the receiver. Electromagnetic shielding is one possibility of protection from electromagnetic radiation. For humans, this protection can be conductive textile materials inserted in suits or hats. Furthermore, conductive materials can be built in wallpaper or curtains for protection from environmental electromagnetic fields. Today, on the market there are textile materials with metal threads mostly from copper or silver. These materials are very light but quite expensive. The aim of proposed research is the analysis of existing textile materials with conductive copper or silver threads for electromagnetic shielding. Research would include development of measurement methods of shielding effectiveness of conductive textile shields on frequencies from 900 MHz to 2.4 GHz as well as their possible application on humans. Furthermore, the durability and life cycle of the mentioned textile materials during use and caring. ]]></summary_en></project><project>
<id>7174</id><title_hr><![CDATA[3D mreže kompleksnih Ge-baziranih nanostruktura u staklima: svojstva i primjene]]></title_hr><title_en><![CDATA[3D networks of complex Ge-based nanostructures in glasses: properties and applications]]></title_en><user_id>1362</user_id><user_firstLast_name>Maja Buljan</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-3633</code><acronim><![CDATA[NetNano]]></acronim><duration>01.09.2018 - 31.08.2022</duration><status>Završio</status><financ_value>158.506,20 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, Kemija, Biologija, Interdisciplinarne prirodne znanosti, </scie_field_hr><scie_field_en>Physics, Chemistry, Biology, Interdisciplinary natural sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>2755, 17815, 21310, 20255, 5657, 3154, 5438, 23403, 3526, 23459, 24100, 329, 27507, 864982, 865363, 865362, 865408, </team_members_id><team_members_names><![CDATA[Ivančica Bogdanović Radović, Nikolina Nekić, Lovro Basioli, Iva Šarić, Krešimir Salamon, Igor Mekterović, Branko Šantić, Božidar Benko, Tihomir Car, Joško Erceg, Dario Mičetić, Nikola Biliškov, Marija Tkalčević, Ivana Periša, Gabrijela Svalina Svalina, Senad Isaković, Marija Šimat, ]]></team_members_names><keywords_hr><![CDATA[nanostrukture, samouređenje, Ge, konverzija energije, pohrana energije, zelena energija]]></keywords_hr><keywords_en><![CDATA[nanostructures, self-assembly, Ge, energy conversion, energy storage, green energy]]></keywords_en><summary_hr><![CDATA[Tijekom proteklih nekoliko godina razvili smo novu klasu materijala baziranih na pravilno uređenim Ge kvantnim točkama (KT) unutar staklene matrice. Ti materijali se pripremaju depozicijom magnetronskim rasprašenjem te naknadnim grijanjem i/ili zračenjem teškim ionima. Ovim projektom planiramo unaprijediti naše istraživanje na novu razinu istražujući kompleksne Ge-bazirane nanostrukture u staklima i njihovu primjenu u uređajima za visoko-učinkovitu konverziju energije  i njeno skladištenje.Naime, svojstva materijala baziranih na čistim, sferičnim Ge KT-ma mogu biti značajno poboljšana ili ciljano dizajnirana dodatkom drugog materijala na Ge KT-e obliku ljuske, pokrovnog sloja ili njihovom izradom u nekom kompleksnijem obliku. Ovi novi materijali, bazirani na kompleksnim Ge nanostrukturama, vrlo su zanimljivi za fundamentalnu znanost, dok njihova visoko prilagodljiva svojstva osiguravaju mogućnost primjene u modernim opto-elektroničkim uređajima.  Očekujemo uspješnu izradu nekoliko novih kompleksnih materijala, uključujući Ge/metal  jezgra/ ljuska KT-e, kontinuirane 3D mreže Ge nanožica i specifične nano-objekte nastale djelovanjem iona u različitim matricama. Razumjet ćemo kako njihova optička i električna svojstva ovise o njihovoj strukturi, te kako ih prilagoditi da bi dobili željena svojstva potrebna za primjene. Kao konačni cilj, iskoristit ćemo ih za proizvodnju energetski učinkovitih staklenika, visoko učinkovite elektrode za cijepanje vode i Li-ion baterije te za spremnike vodika.U konačnici očekujemo da će predloženi projekt donijeti važne rezultate za rješavanje aktualnih problema vezanih uz proizvodnju energije i zdrave hrane te čišćenje okoliša. Također očekujemo širenje znanstvene zajednice zainteresirane za ovu novu vrstu materijala. Ti materijali i uređaji imaju veliki potencijal da budu masovno proizvedeni i primijenjeni u suvremenoj nanotehnologiji budući da je magnetronsko rasprašenje standardna industrijska tehnika za oblaganje stakala.]]></summary_hr><summary_en><![CDATA[During the past several years we have developed a new material class based on regularly distributed Ge quantum dots (QDs) within the glass matrix. These materials are prepared by magnetron sputtering deposition followed by annealing and/or irradiation with heavy ions. We propose to advance our research to a new level by exploring complex Ge-based nanostructures in glasses and their applications in highly-efficient energy conversion and storage devices. Namely, the properties of materials based on pure, spherical Ge QDs can be significantly improved or designed specifically by addition of another material to Ge QDs in form of shell or capping layer, or by creating them to have some more complex shape. These new materials, based on complex Ge nanostructures, are very interesting from the fundamental point of view, while their highly-adjustable properties ensure their possible applications in modern opto-electronic devices.  We expect successful production of several novel complex material types including Ge/metal core/shell QDs, continuous 3D nanowire networks and ion-beam induced specific nano-objects in different matrices. We will understand how their optical and electrical properties depend on their structure and how to tailor them to get the desired properties needed for the applications. As the final goal, we will use them to produce energy-efficient greenhouses, highly-efficient electrodes for water splitting and Li-ion batteries, and hydrogen storage reservoirs.  In final, we expect that the proposed investigation will result in findings important for solving current energy-related problems, healthy food production and environment cleaning. We also expect a widening of scientific community interested for these novel material types. These materials and devices have great potential to be mass-produced and applied in modern nanotechnology since magnetron sputtering is the standard industrial technique for glass coating.]]></summary_en></project><project>
<id>7181</id><title_hr><![CDATA[Razumijevanje zračenja na niskim radio frekvencijama: Ususret novoj generaciji radio teleskopa]]></title_hr><title_en><![CDATA[Understanding foreground emission at low radio frequencies: towards the next generations of radio telescopes]]></title_en><user_id>19010</user_id><user_firstLast_name>Vibor Jelić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-2889</code><acronim><![CDATA[LowFreqCRO]]></acronim><duration>01.10.2018 - 31.03.2023</duration><status>Završio</status><financ_value>126.482,18 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>11144, 5738, 25785, 25825, 28978, 864859, </team_members_id><team_members_names><![CDATA[Vernesa Smolcic, Zeljka Marija  Bosnjak, Luka Turić, Bruno Slaus, Ana Erceg, Lana Ceraj Ceraj, ]]></team_members_names><keywords_hr><![CDATA[radioastronomija, polarimetrija, međuzvjezdana materija, magnetska polja, ekstragalaktički radio izvori]]></keywords_hr><keywords_en><![CDATA[radioastronomy, polarimetry, interstellar medium, magnetic fields, extragalactic radio sources]]></keywords_en><summary_hr><![CDATA[Razumijevanje zračenja na niskim radio frekvencijama ključna je za traženje odgovora na brojna temeljna pitanja u astrofizici. Pomoću novih radio teleskopa osjetljivih na radio zračenje niskih radio frekvencija, znanstvenici bi trebali po prvi put detektirati kozmološko zračenje iz perioda nastanka prvih zvijezda u svemiru, staro nekoliko milijardi godina. Ova vrlo duboka opažanja neće samo otkriti kada i gdje su prvi izvori formirani u ranom svemiru započeli ionizirati pretežno neutralnu sve prožimajuću materiju, već će pružiti visoko kvalitetne podatke za najsuvremeniju znanost zračenja iz prednjeg plana. Samo istraživanje fizike zračenja iz prednjeg plana, bilo galaktičkog ili ektragalaktičkog, je zanimljivo samo po sebi i igra ključnu ulogu u razvoju metoda za eliminaciju zračenja iz prednjeg plana u kozmološkim eksperimentima. Ovdje predlažemo najsuvremenije istraživanje zračenja iz prednjeg plana. Konkretnije, mi ćemo: (i) koristiti radio teleskopa LOFAR za detaljnu tomografiju (lokalne) međuzvjezdane materije (ISM) pomoću opažanja sinhrotronskog zračenja naše galaksije i njegove polarizacije; (ii) kombinirati radio-opažanja s drugim promatranjima (npr. HI, H?, prašina, GRB, zvijezde itd.) kako bi istražili povezanost Faradejevih struktura s ostalim fazama ISMa i njihove povezanost s međuzvjezdanim magnetskim poljima; (iii) izraditi novi model polariziranog zračenja naše Galaksije baziran na LOFARovim promatranjima, a koji će se koristiti za razvoj tehnika uklanjanja zračenja iz prednjeg plana; i (iv) simulacije ekstragalaktičkih radio izvora na temelju rezultata Cosmic Evolution Survey (COSMOS). Financiranje predloženog istraživanja bit će ključno za razvoj    hrvatske astrofizike na međunarodno kompetitivnoj razini, te će rezultati predloženog istraživanja otvoriti put prema ključnim znanstvenim projektima novih generacija radio teleskopa (npr. Square Kilometer Array). ]]></summary_hr><summary_en><![CDATA[Understanding foreground emission at low radio frequencies touches upon many fundamental questions in astrophysics. With the novel low-frequency radio telescopes researchers are expected to detect cosmological radiation emitted billions of years ago, from the time of the first “stars”. These very deep observations will not only set constraints on when and where the first sources formed in the early Universe and began (re)ionizing the predominantly neutral all-pervasive intergalactic medium, but they are also providing high-quality data for cutting edge auxiliary foreground science. Obviously studying the physical origin of the foregrounds, whether Galactic or extragalactic, is a very exciting field in its own right and is of fundamental importance for perfecting the foreground removal techniques in the cosmological experiments. Here, we propose the state-of-the-art study of the foreground emission. In particular, we will: (i) use the novel capabilities of the Low Frequency Array (LOFAR) radio telescope to conduct the detailed tomography of the local interstellar medium (ISM) by observing Galactic synchrotron emission and its polarization; (ii) combine these radio observations with other observational probes (e.g. HI, H?, dust, GRB afterglows, close-by stars, etc.) to investigate the association of Faraday structures with different ISM phases and association with the interstellar magnetic fields; (iii) built new data driven model of Galactic polarized emission that will be used for development of the foreground removal techniques; and (iv) simulations of extragalactic radio sources, based on the Cosmic Evolution Survey (COSMOS) results. Funding of the proposed research is essential to keep Croatian astrophysics at an internationally competitive level and go beyond this by providing results that will pave the way for the key science cases of the next generation of radio telescopes (e.g. Square Kilometer Array). ]]></summary_en></project><project>
<id>7184</id><title_hr><![CDATA[Molekularni aspekti patogenih procesa u AHCY deficijenciji]]></title_hr><title_en><![CDATA[Molecular aspects of disease pathogenesis in AHCY deficiency]]></title_en><user_id>54</user_id><user_firstLast_name>Oliver Vugrek</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-5632</code><acronim><![CDATA[MAPinAD]]></acronim><duration>30.04.2019 - 29.10.2023</duration><status>Završio</status><financ_value>130.777,16 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, Clinical sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>2896, 19486, 5101, 19242, 23450, 3891, 629, 23732, 23885, 28663, 865294, 866649, </team_members_id><team_members_names><![CDATA[Robert Belužić, Jorge Boucas, Josipa Vlainić, Filip Rokić, Grant Morahan, Kristina Crkvenac Gornik, Marko Marjanović, Darija Mužinić, JONG HOON PARK, Ivana Pavičić, Katrin Nedeljko, Gokhan Dogukan Akarsu, ]]></team_members_names><keywords_hr><![CDATA[Odgovor na oštećenje DNA, adenozin, stanični ciklus, karcinogeneza, bolest jetre, metastaza, transkriptomika]]></keywords_hr><keywords_en><![CDATA[DNA damage response, adenosine, cell cycle, cancerogenesis, liver disease, metastasis, transcriptomics]]></keywords_en><summary_hr><![CDATA[S-adenozilhomocistein hidrolaza (AHCY) katalizira hidrolizu S-adenozilhomocisteina (SAH) na adenozin (Ado) i homocistein (Hcs). Novija istraživanja ukazuju na povezanost AHCY i raka na nekoliko razina: AHCY može regulirati fenotipska obilježja stanica raka; AHCY kao ciljna molekula u terapijskim pristupima te kao biomarker za određena maligna oboljenja. Veza između adenozina (jednog od produkata hidrolize SAH) i raka jednim dijelom je poznata te uključuje stimulaciju proliferacije i ulogu u regulaciji upalnih/imunoloških procesa. Također, aktivnost AHCY u vezi je s razvojem patoloških promjena jetre, što potvrđuje i nedavno objavljen slučaj hepatocelularnog karcinoma kod pacijenta s nedostatnom aktivnošću AHCY.  Naši preliminarni podaci na stanicama hepatocelularnog karcinoma (HepG2) pokazuju da smanjena aktivnost AHCY uzrokuje sniženje razine Ado, uslijed čega dolazi do oštećenja DNA i zastoja u staničnom ciklusu. Iako navedeni podaci pokazuju ulogu AHCY u mehanizmima nastanka malignih oboljenja, točna molekularna podloga te veze nije razjašnjena. Da bismo je razjasnili, koristit ćemo &#39;multi-omics&#39; pristup, uz klasične metode kao što su analiza staničnog ciklusa, proliferacije i oštećenja DNA, na uzorcima tkiva i serumu pacijenata s patološkim promjenama jetre, odabranim staničnim linijama s utišanom ekspresijom AHCY, te na novorazvijenom transgeničnom mišu kao in vivo modelu.  Ispitat će se utjecaj sniženja razina adenozina (kao rezultat smanjene aktivnosti AHCY) na stanični metabolizam te predložiti mehanizam koji povezuje aktivnost AHCY, nastanak oštećenja DNA i regulaciju staničnog ciklusa. Rezultati predloženog istraživanja mogli bi unaprijediti terapijske pristupe u liječenju malignih oboljenja povezanih s smanjenom aktivnošću AHCY, te potaknuti razvoj novih metoda liječenja baziranih na regulaciji pomoću adenozina.]]></summary_hr><summary_en><![CDATA[S-adenosylhomocysteine hydrolase (AHCY) catalyzes the hydrolysis of S-adenosylhomocysteine (SAH) to Adenosine (Ado) and Homocysteine (Hyc). Recently, several studies pointed out connections of AHCY with cancer from various standpoints: as a player that possibly regulates cancer phenotype, as a druggable candidate, or, as a promising biomarker. Metabolome-wise, connections between adenosine and cancer have been established, showing stimulative effects on cell proliferation, and other important roles in inflammation or immunity. Implications of AHCY in hepatic pathology are well documented, and culminated in the recently reported case of hepatocellular carcinoma in an adult with AHCY deficiency. Also, as we have preliminary data showing that low AHCY activity and depletion of adenosine induces DNA damage and cell cycle arrest in hepatocellular carcinoma cells. In summary, involvement of AHCY in molecular mechanisms of cancer is undisputable. However, the molecular basis for the connection between AHCY and cancer is not quite obvious. In order to answers these questions we will deploy a multi-omics approach, in combination with basic molecular and cellular biology procedures focus on the role of AHCY and its mechanism of action on cell cycle, cellular proliferation and DNA damage response in histological and serum samples of liver disease patients, in relevant cancerous and AHCY deficient cell lines, and a unique mouse animal model. In particular, we will investigate the implications of adenosine, besides homocysteine, the primary product of AHCY hydrolytic activity on the cellular metabolism.  By answering these questions we hope to establish the mechanism that connects AHCY activity, DNA damage and regulation of cell cycle through adenosine levels. The outcomes of underlying research may lead to a refinement of therapeutical procedures for cancer as a result of AHCY malfunction, and a potentially new approach for targeted cancer therapy based on adenosine depletion. ]]></summary_en></project><project>
<id>7185</id><title_hr><![CDATA[Sport, diskriminacija i integracija. Sport kao medij društvene inkluzije i participacije]]></title_hr><title_en><![CDATA[Sport, discrimination, and integration. Sport as a vehicle of social inclusion and participation]]></title_en><user_id>19056</user_id><user_firstLast_name>Goran-Pavel Šantek</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-2756</code><acronim><![CDATA[INTEGRA]]></acronim><duration>01.01.2019 - 31.12.2022</duration><status>Završio</status><financ_value>79.633,69 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Etnologija i antropologija, </scie_field_hr><scie_field_en>Ethnology and anthropology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>23670, 19922, 19822, 19921, 19942, 25511, </team_members_id><team_members_names><![CDATA[Rahela Jurković, Anton Vukelić, Tibor Komar, Marijeta Rajković Iveta, Andrew Hodges, Andrej Ivan  Nuredinović , ]]></team_members_names><keywords_hr><![CDATA[Sport, integracija, diskriminacija, inkluzija, participacija]]></keywords_hr><keywords_en><![CDATA[Sport, integration, discrimination, inclusion, participation]]></keywords_en><summary_hr><![CDATA[Pitanje društvene kohezije nerazdvojivo je povezano s problemima integracije i diskriminacije, osobito prema rasi, regionalnoj, etničkoj ili nacionalnoj pripadnosti, ali i svakoj drugoj kulturnoj različitosti.U ovom će se projektu istraživanja provoditi u dva glavna, no međusobno ispreplićuća, istraživačka smjera: a) kroz istraživanja integracije, inkluzije i diskriminacije, kako se u sportu očituju kroz navijače, članove klubova i same sportaše, te b) kroz istraživanja migranata, postmigracijskih procesa i njihova kontekstualiziranja uz sport.Istraživanje se načelno može smjestiti unutar socijalnih koncepata koji razmatraju različite modele povećanja društvene inkluzivnosti i integracije s ciljem promoviranja društveno prihvatljivih obrazaca ponašanja, a sukladno Kevin T. Leichtu (2016). Put ka društvenoj inkluziji koncipiran je stadijima Gorana Therborna (2013).Kroz istraživanje navijača i klupskih članova, ali i migranata u sportu, njihov aktivizam, proteste, peticije, kampanje, radionice, svu javnu verbalnu i vizualnu ekspresiju te druge oblike djelovanja proučit će se njihova samopercepcija i osjećaj,  kako na razini pojedinaca  tako i skupine, diskriminiranosti i marginaliziranosti te kao onih kojima su ugrožena građanska i ljudska prava te kako klubovi djeluju na inkluziju i ekskluziju građana, odnosno kao oruđa društvene kohezije.Očekivani učinak  projekta je doprinos modelima za povećanje inkluzije i umanjenje ekskluzije navijača i migranata putem sporta, odnosno sporta kao oruđa društvene kohezije.Istraživanje će biti zasnovano na različitim praksama kvalitativne i kvantitativne metodologije, posebno na diskurzivnoj analizi, sudioničkom promatranju, etnografskom bilježenju, slobodnim i strukturiranim intervjuima, analizama verbalne i vizualne ekspresije, ali i anketnom upitniku socijalne distance.]]></summary_hr><summary_en><![CDATA[Questions concerning social cohesion are inseparable from those connected with problems of integration and discrimination, especially as regards race, regional, ethnic, sexual or national difference, as well as other kinds of social, cultural and human diversity.Research will be conducted in two main, interrelated research streams: a) through researching integration, inclusion and discrimination as understood by fans, members of clubs and athletes themselves, and b) through researching refugees, migrants, post-migration processes and their contextualising within sport.Such research, according to Leichtu (2016), may be situated inside a framework using social concepts, which consider different models of increasing social inclusion and integration with the aim of promoting socially acceptable patterns of behaviour. The path to social inclusion has been conceived according to Goran Therborne (2013).Fans and/or members of sports’ clubs, but also migrants active in sport, and their self-perceptions and feelings will be studied through their activism, protests, petitions, campaigns, workshops, and through all of their forms of public verbal, visual expression and action. They will be studied both at the individual and group level, including their discrimination and marginalization, and the endangering of their civil and human rights. How clubs work to include and exclude citizens, playing a role as a tool for social cohesion, will also be considered.One of the expected effects from the project is the contribution to models of improvements of fans and migrants’ inclusion and reduction of their exclusion, that is the improvement of sport as a vehicle of social cohesion.Research will be based on various practices of qualitative and quantitative methodology, especially on discursive analysis, participant observation, ethnographic note-taking, free and structured interviews, analysis of verbal and visual expression, but also on poll questionnaire of social distance.]]></summary_en></project><project>
<id>7187</id><title_hr><![CDATA[Kolektivna dinamika u magnetoelektricima]]></title_hr><title_en><![CDATA[Colective Dynamics in Magnetoelectrics]]></title_en><user_id>3184</user_id><user_firstLast_name>Tomislav Ivek</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-2730</code><acronim><![CDATA[ColDynaMo]]></acronim><duration>01.10.2018 - 30.09.2023</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut za fiziku]]></institution_hr><institution_en><![CDATA[Institute of Physics in Zagreb]]></institution_en><team_members_id>23242, 21233, 12365, 2842, 21185, 11197, 2873, 28904, </team_members_id><team_members_names><![CDATA[Željko Rapljenović, Martina Dragičević, Damir Dominko, Matija Čulo, David Rivas Góngora, Mirta Herak, Nikolina Novosel, Virna Kisiček, ]]></team_members_names><keywords_hr><![CDATA[multiferoik,magnetoelektrik,dielektrik,susceptibilnost,infracrveno,spektroskopija]]></keywords_hr><keywords_en><![CDATA[multiferroic,magnetoelectric,dielectric,susceptibility,infrared,spectroscopy]]></keywords_en><summary_hr><![CDATA[Multiferoični i magnetoelektrični sustavi su novi materijali u fizici čvrstog stanja s izravnom primjenom u industriji visoke tehnologije. Tome svjedoči rastući broj publikacija svake godine u časopisima s visokim faktorom utjecaja. Koristeći zajedno naše kompetitivne i komplementarne eksperimentalne tehnike na Institutu za fiziku u jedinstvenom smo položaju da istražimo ovu široku klasu uzbudljivih materijala. Naš predloženi projekt u skladu je s dva infrastrukturna projekta na Institutu za fiziku: Kriogeni centar Instituta za fiziku - KaCIF i Centar za napredne laserske tehnike - CALT. Sinergija ovog projektnog prijedloga s novim mogućnostima KaCIF-a i CALT-a će dati i nova fundamentalna saznanja o magnetoelektričnom vezanju odgovornom za egzotičnu multiferoičnost. Očekujemo visoki broj publikacija u vrhunskim časopisima iz područja. Ovaj prijedlog je također i platforma za doktorande i poslijedoktorande koji će nam se pridružiti u istraživanju da razviju svoju karijeru. Također planiramo proširiti naše istraživanje slanjem novih projektnih prijedloga na kompetitivne natječaje drugih izvora financiranja.Posebno, namjeravamo istražiti tri grupe multiferoičnih materijala: frustrirane nesumjerljive antiferomagnete, višedomenske magnete s električnom polarizacijom te heksaferite s kemijskom kontrolom svojstava. Cilj je sistematski opisati njihova kolektivna pobiuđenja u sektoru naboja i spina koristeći THz zračenje, magnetska, transportna i dielektrična mjerenja.]]></summary_hr><summary_en><![CDATA[Multiferroics and magnetoelectric systems are novel materials in solid state science with direct application in the high-tech industry. This is evidenced by the growing number of publications in high-impact-factor journals each year. Combining our competitive and complementary experimental techniques at Institute of Physics, we are uniquely positioned to research this broad and exciting class of materials. Our proposed project is in line with two infrastructural projects at our Institute: Cryogenic Centre at the Institute of Physics - KaCIF and Centre for Advanced Laser Techniques - CALT. The synergy of this project proposal with the new possibilities within KaCIF and CALT will result in new fundamental understanding about magnetoelectric coupling ruling a selection of exotic new multiferroics. We expect high publicability in top journals in the field. This proposal is also a platform for doctoral and postdoc students joining us in research to develop their careers. We also plan to extend our research by submitting new proposals to competitive funding calls of other funding agencies.Specifically, we plan to research three groups of multiferroic materials: frustrated incommensurate antiferromagnets, multi-domain magnets with electric polarization as well as chemically-controlled hexaferrites. The aim is to systematically describe their collective excitations in the spin and charge sector using THz radiation, magnetic, transport and dielectric bulk techniques.]]></summary_en></project><project>
<id>7188</id><title_hr><![CDATA[Utjecaj majčinog metaboličkog stanja na serotoninski sustav posteljice i neonatusa: od metilacije DNA do funkcije proteina]]></title_hr><title_en><![CDATA[Influence of maternal metabolic state on placental and neonatal serotonin system: from DNA methylation to protein function]]></title_en><user_id>519</user_id><user_firstLast_name>Jasminka Stefulj</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-6547</code><acronim><![CDATA[PLANS]]></acronim><duration>01.12.2018 - 01.06.2023</duration><status>Završio</status><financ_value>131.395,58 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>5668, 5996, 5314, 22574, 19949, 12342, 12701, 12354, 23562, 2514, 19126, 21427, 28681, 28959, 861748, 23790, </team_members_id><team_members_names><![CDATA[Lipa Čičin-Šain, Maja Kesic, Dubravka Hranilovic, Barbara Nikolić, Desoye Gernot, Marina Ivanisevic, Josip Juras, Marina Horvatiček, Mirta Starčević, Saša Kralik Oguić, Sandra Nakić Radoš, Maja Anđelinović, Maja Perić, Marina Kukolj, Maja Žutić, Ivona Bečeheli, ]]></team_members_names><keywords_hr><![CDATA[serotonin, posteljica, krv iz pupkovine, metilacija DNA, gestacijski dijabetes]]></keywords_hr><keywords_en><![CDATA[serotonin, placenta, cord blood, DNA methylation, gestational diabetes]]></keywords_en><summary_hr><![CDATA[Serotonin (5HT) je multifunkcionalna signalna molekula, najpoznatija kao neurotransmiter središnjeg živčanog sustava. Osim toga, 5HT igra važne ekstracerebralne uloge, kako u odrasloj dobi tako i tijekom razvoja. Poremećaji 5HT homeostaze povezuju se s mnogim mentalnim zdravstvenim problemima, a pojavljuju se i kao važan čimbenik u pretilosti i dijabetesu. Sve više dokaza sugerira da metilacija DNA modulira ekspresiju 5HT-regulirajućih gena i da može doprinositi  serotoninskoj disfunkciji. Metilacija DNA je dinamičan proces osjetljiv na okolinske utjecaje, posebno tijekom ranog razvoja. Naši nedavni rezultati upućuju da je posteljična metilacija DNA gena za 5HT prijenosnik (SLC6A4), glavni regulator 5HT signalizacije, osjetljiva na majčine metaboličke nepravilnosti povezane s gestacijskim dijabetes melitusom (GDM). Ovaj projekt usmjeren je na daljnje razumijevanje utjecaja majčinog metaboličkog stanja u trudnoći na 5HT sustav posteljice i novorođenčeta. Korištenjem tkiva posteljice i primarnih stanice posteljice dobivenih iz klinički dobro definiranih zdravih i GDM trudnoća, istražit ćemo odnos majčine gestacijske glikemije i predgestacijskog indeksa tjelesne mase (pITM) s posteljičnom metilacijom i ekspresijom gena SLC6A4 i gena za 5HT receptor tipa 2A (HTR2A). Nadalje, studijama in vitro na humanim primarnim trofoblastima istražit ćemo kako izloženost glukozi utječe na metilaciju DNA i ekspresiju gena SLC6A4 te na funkciju odgovarajućeg genskog produkta (aktivnost unosa serotonina). Konačno, istražit ćemo odnos majčine glikemije i pITM s 5HT sustavom novorođenčeta, mjerenjem serotoninskih biokemijskih parametara (razina 5HT, aktivnost 5HT prijenosnika, agregacija trombocita) i metilacije DNA 5HT-regulirajućih gena u krvi iz pupkovine.]]></summary_hr><summary_en><![CDATA[Serotonin (5HT) is a multifunctional signaling molecule, the best known as the central nervous system neurotransmitter. In addition, 5HT plays important extra-cerebral roles, both in adulthood and during development. Disturbances in 5HT homeostasis have been linked to many mental health conditions and are emerging as an important contributor also to obesity and diabetes. Rising evidence suggests that DNA methylation modulates expression of 5HT-regulating genes and may contribute to 5HT dysfunction. DNA methylation is a dynamic process sensitive to environmental influences, particularly during early development. Our recent results suggest that placental DNA methylation of the 5HT transporter gene (SLC6A4), a principal regulator of 5HT signaling, is sensitive to maternal metabolic derangements associated with gestational diabetes mellitus (GDM). This project is aimed to further understand impact of maternal metabolic state in pregnancy on placental and newborn&#39;s 5HT system. Using placental tissue and  primary placental cells obtained from clinically well-defined healthy and GDM pregnancies, we will investigate relationship of maternal gestational glycaemia and pregestational body mass index (pBMI) with placental DNA methylation and expression of SLC6A4 and 5HT receptor type 2A (HTR2A) genes. In addition, by in vitro studies in human primary trophoblasts, we will investigate how exposure to glucose affects SLC6A4 DNA methylation and expression as well as function of the corresponding gene product (serotonin uptake activity). Finally, we will investigate relathionship of meternal glycemia and pBMI with newborn&#39;s 5HT system, by measuring 5HT-related biochemical parameters (5HT levels, platelet 5HT uptake, platelet aggregation) and DNA methylation of 5HT-regulating genes in umbilical cord blood.]]></summary_en></project><project>
<id>7190</id><title_hr><![CDATA[HRVATSKI MONITOR NASILJA - Istraživanje pojavnih oblika, uzroka i procesuiranja delinkventnog nasilja s fokusom na zaštiti posebno ranjivih skupina žrtava]]></title_hr><title_en><![CDATA[]]></title_en><user_id>21439</user_id><user_firstLast_name>Reana Bezic</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-6494</code><acronim><![CDATA[CroViMo]]></acronim><duration>01.11.2018 - 31.03.2023</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Pravo, </scie_field_hr><scie_field_en>Law, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Pravni fakultet u Zagrebu]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Law]]></institution_en><team_members_id>22461</team_members_id><team_members_names><![CDATA[ Doktorand: Petra Šprem ]]></team_members_names><keywords_hr><![CDATA[kriminologija, nasilje, prevencija nasilja, ubojstvo, kibernetičko uznemiravanje, Hrvatska]]></keywords_hr><keywords_en><![CDATA[criminology, violence, violence prevention, homicide, cyber harassment, Croatia]]></keywords_en><summary_hr><![CDATA[Projekt CroViMo ima za cilj uspostavljanje multidisciplinarne grupe mladih znanstvenika koji će provoditi inovativna istraživanja nasilja u Hrvatskoj kroz svoj „Laboratorij za analizu nasilja“. Glavni cilj istraživanja je empirijsko i normativno snimiti te analizirati fenomenologiju, etiologiju i procesuiranje delinkventnog nasilja u Hrvatskoj, pri čemu će naglasak biti na posebno ranjivim skupinama žrtava sa svojim vrlo specifičnim i različitim potrebama zaštite od nasilja. Te posebno ranjive skupine uključuju: djecu; žene i djevojke; starije; manjine, strance, izbjeglice i migrante; osobe u institucionaliziranoj skrbi; osoblje rizičnih zanimanja; i LGBT. Za razliku od uobičajenog tzv. „mainstream“ istraživanja nasilja, koje se uglavnom fokusira na specifične (pod)vrste nasilja i/ili skupine žrtava izvan općeg konteksta delinkventnog nasilja, CroViMo će prvo provesti izvorno istraživanje ukupnog delinkventnog nasilja, prije no što se fokusira na njegove pojedine (pod)vrste. Ovaj holistički pristup temelji se na pretpostavci da proučavanje određene (pod)vrste nasilja, bez empirijskih podataka o općem nasilnom kontekstu dovodi do fragmentarnih, a potencijalno i iskrivljenih shvaćanja pojedinih promatranih (pod)vrsta nasilja. Glavni zadatak CroViMo biti će razviti i testirati novu inovativnu klasifikaciju delinkventnog nasilja, „autentični sustav klasifikacije nasilja”, koja neće podlijegati normativnim ograničenjima trenutnih klasifikacija, nego će biti usredotočena isključivo na sam fenomen nasilja. Takav sustav klasifikacije mogao bi označiti prekretnicu u području istraživanja nasilja. Ovaj ambiciozni plan rada, ukoliko bi bio uspješno proveden, trebao bi dugoročno osigurati razvoj projekta CroViMo u prepoznatljiv nacionalni, regionalni i europski „Laboratorij za analizu nasilja“, te privući daljnje nacionalne i međunarodne znanstvene suradnje i uspješne nove kolaborativne projektne prijave, s velikim potencijalom za prijenos znanstvenih spoznaja u praksu.]]></summary_hr><summary_en><![CDATA[The CroViMo project aims at setting up a multidisciplinary nationwide research group of young researchers for conducting innovative violence research in Croatia through its&#39; “Violence Research Lab”. The central research objective is to empirically and normatively capture and analyse the phenomenology, etiology, and prosecution of delinquent violence in Croatia, with special focus on particularly vulnerable groups of victims with their very specific and diverse needs for protection from violence. These particularly vulnerable groups include: children; women and girls; the elderly; minorities, foreigners, refugees and migrants; persons in institutional custody; risky professions’ personnel; and LGBT. In contrast to ‘mainstream’ violence research, which predominantly focuses on specific (sub)types of violence and/or victim groups outside the overall context of general delinquent violence, CroViMo will conduct genuine foundational research on the total of delinquent violence, before focusing on its’ certain (sub)types. This broad approach is based on the premise that the study of certain (sub)types of violence without empirical data on the overall violent context leads to fragmentary, and potentially distorted understandings of the (sub)types in question. The main task of CroViMo will be to develop and test an innovative new classification of delinquent violence, the “genuine violence classification system” that will blend out the normative constraints of current mainstream classifications and focus strictly on the violence itself. Such a classification system might be a breakthrough in violence research. This ambitious work plan, if implemented successfully, should in the long run facilitate CroViMo’s development into a recognisable national, regional, and European “Violence Research Lab”, attracting further national and international scientific cooperation and successful joint funding applications, with a huge potential for dissemination of findings into practice.]]></summary_en></project><project>
<id>7192</id><title_hr><![CDATA[Nove primjene 14 MeV neutrona]]></title_hr><title_en><![CDATA[Addvanced applications of 14 MeV neutrons]]></title_en><user_id>1377</user_id><user_firstLast_name>Davorin Sudac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-4060</code><acronim><![CDATA[NeA]]></acronim><duration>01.10.2018 - 31.03.2023</duration><status>Završio</status><financ_value>132.112,28 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>3983, 4190, 2505, 23275, 23358, 185, 23522, 25523, 28636, 861467, 866585, </team_members_id><team_members_names><![CDATA[Jasmina Obhođaš, Milorad Korolija, Vladivoj Valković, Karlo Nađ, Ilker Meric, Milivoj Uroić, Helge Egil Seime Pettersen, Dubravko Rendić, Martina Pavlovic Pavlovic, Josip Batur, Hadi Shahabinejad, ]]></team_members_names><keywords_hr><![CDATA[neutroni,istraživanje nafte, metan hidrat, rijetke zemlje, standardni materijali, metode detekcije, nove analitičke metode]]></keywords_hr><keywords_en><![CDATA[neutrons, oil logging, methane hydrate, rare earth elements, standard materials, method of detection, new analytical methods]]></keywords_en><summary_hr><![CDATA[Razvit će se metoda primjene brzih pulsiranih neutrona i/ili metode pridružene alfa čestice u istraživanju nalazišta metan hidrata (MH) i elemenata rijetkih zemalja (ERZ). Nalazišta metan hidrata mogu poslužiti kao izvor energije jednako značajan kao i postojeći fosilni izvori energije. Razvit će se metoda pasivnog određivanja koncentracija ERZa pomoću radioaktivnog izotopa 176Lu. Razviti će se kalibracijski postupak za neutronske senzore koji mjere C/O, N/C omjere kao i omjere drugih elemenata od interesa (Al, Si, P, S, Cl, Fe, …). Kako koncentracije elemenata mjerena neutronskim senzorom ovise o okruženju, kalibracijski postupak će se ponoviti za različita tipična okruženja (mineralna, metalna ili organska matrica). Specijalna pažnja posvetiti će se razvoju nove instrumentacije u istraživanju naftnih bušotina (Carbon-to Oxygen oil logging). Cilj istraživanja je razviti metodologiju mjerenja varijacija omjera koncentracija kemijskih elemenata, naročito C/O omjera na maloj skali, što može značajno povećati efikasnost eksploatacije već postojećih naftnih bušotina. Ciljevi istraživanja su:-	Razvoj metoda za ispitivanje podvodnih MH, ERZ i drugih mineralnih nalazišta od interesa-	Razvoj naprednih nuklearnih senzora, naročito za monitoriranje sirove nafte, precizno mjerenja C/O omjera u naftnim bušotinama, uz pomoć najnovijih tehnologija-	Razvoj ‘’ Quality Assurance/Quality Control QA/QC’’ procedure za neutronske sisteme-	Izobrazba mladih istraživača]]></summary_hr><summary_en><![CDATA[Applications of nuclear analytical methods in exploring and monitoring of methane hydrate (MH) and rare earth elements (REE) deposits will be developed by using the pulsed fast neutrons and/or associated alpha particle imaging (API) technique. Methane hydrate deposits can serve as an energy source favorably to the all of the world remaining conventional hydrocarbon sources. A method of passive determination of the REE concentration using a radioactive isotope 176Lu will be developed. The calibration procedures for neutron interrogation systems will be developed for measuring the C/O, N/C ratios and ratios of the other elements of interest (Al, Si, P, S, Cl, Fe, …). Since the concentration values measured by neutron interrogation systems depend on surrounding material too, the calibration procedure will be repeated for different types of surrounding (mineral, metal or organic matrix). Special interest shall be assigned to development of a new instrumentation in Carbon-to-Oxygen (C/O) oil logging. The aim of this research would be the development of a methodology for the measurement of small scale variations in chemical elements concentrations, in particular of C/O ratio, which could significantly increase the exploitation of the existing oil wells.  The specific research objectives are: -	Development of methods for investigation of underwater MH, REE and other mineral deposits of interest;-	Development of advanced nuclear sensors, in particular for crude oil monitoring and for precise C/O logging for very thin layers, coupled with cutting-edge developments in neutron generators, detector technologies, “smart” collimators and analysis techniques.-	Development of the Quality Assurance/Quality Control QA/QC procedures for neutron interrogation systems; -	Hands on training of young researchers.]]></summary_en></project><project>
<id>7197</id><title_hr><![CDATA[Tradicionalizam i inovacije u Dubrovniku  od srednjeg vijeka do devetnaestog stoljeća]]></title_hr><title_en><![CDATA[Traditionalism and Innovation in Dubrovnik  from the Middle Ages until the Nineteenth Century]]></title_en><user_id>739</user_id><user_firstLast_name>Zdenka Janeković Roemer</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-5527</code><acronim><![CDATA[INTRADA]]></acronim><duration>01.07.2019 - 30.06.2023</duration><status>Završio</status><financ_value>77.315,02 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Povijest, </scie_field_hr><scie_field_en>History, </scie_field_en><institution_hr><![CDATA[Hrvatska akademija znanosti i umjetnosti]]></institution_hr><institution_en><![CDATA[Croatian Academy of Sciences and Arts]]></institution_en><team_members_id>458, 386, 481, 398, 726, 389, 430, 1112, 1097, 330, 1078, 23252, 23278, 401, </team_members_id><team_members_names><![CDATA[Stanislava (Slavica) Stojan, Nella Lonza, Vesna Miović, Relja Seferović, Lovro  Kunčević, Rina Kralj-Brassard, Irena Ipšić, Marinko Marić, Kristina Puljizević, Zrinka Pešorda Vardić, Domagoj Madunić, Ariana Violić-Koprivec, Vedran Stojanović, Maja Katušić, ]]></team_members_names><keywords_hr><![CDATA[Dubrovnik, Dubrovačka Republika, tradicionalizam, inovacija, srednji vijek, rani novi vijek]]></keywords_hr><keywords_en><![CDATA[Dubrovnik, Dubrovnik Republic, traditionalism, innovation, Middle ages, Early modern period]]></keywords_en><summary_hr><![CDATA[Polazeći od recentne historiografije posvećene “konstrukcijama” prošlosti, projekt ispituje različite artikulacije tradicionalizma i posljedice tih artikulacija na politiku, društvo i stanovništvo predmodernog Dubrovnika. Tradicionalizam ovdje znači specifičan mentalitet koji prošlost doživljava kao normativnu, odnosno kao ideal za sadašnjost. Cilj projekta je istražiti tradicionalizam predmodernog Dubrovnika kroz koordinirano interdisciplinarno istraživanje sedamnaest povjesničara politike, društva i stanovništva. S obzirom da se tradicionalizam može razumjeti samo kroz međuodnos s inovacijom, projekt se također bavi raznim konceptualizacijama i promicateljima onoga što je smatrano novinom. Predmoderni Dubrovnik je odabran za predmet istraživanja iz dva glavna razloga: radilo se o izrazito tradicionalističkoj sredini koja je iznimno dobro dokumentirana. Sve u svemu, glavni cilj projekta jest: a) rekonstruirati tradicionalističku ideologiju i tradicionalističke povijesne mitove predmodernog Dubrovnika, vezane uz različite aspekte života, od prava preko politike do društvenih običaja; b) analizirati njihove autore (pojedince, skupine, institucije), svrhe i kontekste njihova pojavljivanja; c) rekonstruirati posljedice takvih tradicionalističkih konceptualizacija prošlosti na politiku, društvo i stanovništvo; d) istražiti konceptualizacije i promicatelje inovacije kao i načine na koje je interaktirala s tradicionalizmom.Projekt ima i dva dodatna cilja: prvo, unaprijediti vidljivost hrvatske historiografije kroz diseminaciju rezultata i drugo, unaprijediti istraživačke vještine doktorskih studenata uključenih u istraživački tim.Projekt će rezultirati s najmanje šesnaest izvornih znanstvenih radova, četiri znanstvene monografije, tri radionice i međunarodnom konferencijom.]]></summary_hr><summary_en><![CDATA[Building on the recent historiography on the “construction” of the past, the project investigates various articulations of traditionalism and their effect on the politics, society, and population of pre-modern Dubrovnik. Traditionalism designates a specific mentality which understood the past as being normative, i.e. as representing an ideal for the present. The goal of the project is to investigate Dubrovnik’s traditionalism in the Early modern period through a coordinated interdisciplinary research of seventeen historians of politics, society and population. However, since traditionalism can be understood only through its interplay with innovation, the project also focuses on various conceptualizations and propagators of what was considered to be new. The case-study of premodern Dubrovnik was chosen for two main reasons: it was a strongly traditionalist milieu and, moreover, an excellently documented one. In sum, the main research goal of the project is to: a.) reconstruct the traditionalist ideology and traditionalist historical myths of premodern Dubrovnik regarding the various aspects of life, from law and politics to social customs b.) analyse their creators (individuals, groups, institutions), their purposes, and contexts c.) reconstruct the effect of such traditionalist conceptualizations of the past on politics, society and population d.) investigate the conceptualizations and propagators of innovation as well as the means in which it interacted with traditionalism. The project also has two additional goals: first, improving the visibility of Croatian historiography through the dissemination of the project results; second, improving the research skills of PhD students engaged in the project.The project will result with minimally sixteen research articles, four monographs, three workshops and an international conference. ]]></summary_en></project><project>
<id>7200</id><title_hr><![CDATA[Istraživanje antroponimije na tlu Hrvatske u XV. stoljeću]]></title_hr><title_en><![CDATA[Research of the 15th century anthroponymy on the territory of Croatia]]></title_en><user_id>23405</user_id><user_firstLast_name>Ankica Čilaš Šimpraga</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-6053</code><acronim><![CDATA[CroNominaXV]]></acronim><duration>01.10.2018 - 30.09.2022</duration><status>Prekinut</status><financ_value>57.811,37 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filologija, </scie_field_hr><scie_field_en>Philology, </scie_field_en><institution_hr><![CDATA[Institut za hrvatski jezik]]></institution_hr><institution_en><![CDATA[Institute of Croatian Language]]></institution_en><team_members_id>19104, 19099, 23406, 6131, 5332, 23460, 818, </team_members_id><team_members_names><![CDATA[Domagoj Vidović, Joža Horvat, Ivan Botica, Dubravka Ivšić Majić, Branimir Brgles, Marijana Belaj, Anđela Frančić, ]]></team_members_names><keywords_hr><![CDATA[antroponimija, antroponomastika, Hrvatska, XV. stoljeće, osobna imena, antroponimijska formula]]></keywords_hr><keywords_en><![CDATA[anthroponymy, anthroponomastics, Croatia, 15th century, personal names, name formula]]></keywords_en><summary_hr><![CDATA[Petnaesto je stoljeće granično razdoblje u hrvatskoj antroponimiji s obzirom na to da od XVI. st., zbog povijesnih prilika, nastaju velike promjene u osobnoimenskome repertoaru i strukturi antroponimijske formule. Temeljni je cilj ovoga projekta stvaranje prve hrvatske antroponomastičke javno dostupne baze podataka te onomastička interpretacija osobnih imena i antroponimijskih formula ekscerpiranih iz reprezentativnih vrela iz XV. stoljeća. S obzirom na to da je osobno ime sociolingvistički znak te da su motivi nastanka i izbora imena ovisni o povijesnim, kulturnim, gospodarskim i političkim prilikama te svjetonazoru i običajima puka, pristup je obradbi antroponimijske građe interdisciplinaran. Zbog toga će u projektnoj skupini uz jezikoslovce surađivati povjesničari te i jedan etnolog. U rad će se uključiti i doktorand kako bi se izgradio mladi znanstvenik specijaliziran za povijesnu antroponomastiku.Antroponimi će se obrađivati u računalnoj bazi u programu Tlex prema metodologiji razvijenoj u dosadašnjim projektima i radovima uključenih suradnika. Dobivena imenska građa omogućit će: (1) analizu strukture antroponimijskih formula u pojedinim hrvatskim krajevima, (2) usporedbu osobnoimenskih repertoara s obzirom na čestoću imena, odnos između imena narodnoga i svetačkoga podrijetla, razlike u nadijevanju imena između seoskih i gradskih sredina te između pripadnika nižih i viših društvenih slojeva te (3) analizu dominantnoga adstratnog jezičnog utjecaja u različitim dijelovima Hrvatske. Jedan je od ciljeva projekta s pomoću interaktivnih zemljovida prikazati: (1) prostiranje najčešćih osobnih imena i (2) distribuciju najčešćih tvorbenih osnova i sufiksa. Rezultati rada na projektu javnosti će biti predstavljeni i kroz znanstvene studije, sudjelovanje na znanstvenim konferencijama i organiziranje znanstvene konferencije posvećene povijesnoj antroponimiji.]]></summary_hr><summary_en><![CDATA[Significant historical changes during the 15th c. influenced significant fractures in Croatian historical anthroponymy. The most notable changes, encountered by the beginning of the 16th c., included considerable transformations in the repertoire of personal names, variations in naming patterns and in the structure of the name formula. Proposed research is focused on excerpting attestations of personal names from selected and highly representative 15th-century sources into a database, which will also include onomastic interpretations and historical context for each name record, and in turn will be publicly available. Keeping in mind that a name is a sociolinguistic sign, and that the motives for its creation are interdependent with historical and cultural circumstances, as well as religious and other popular customs, the research methodology implies an interdisciplinary approach. Therefore the research team includes linguists, historians and an ethnologist, as well as a doctoral student.The database, which will be used to excerpt, document and interpret the attestations of anthroponyms, will be built using Tlex software. The database will enable: 1) analysis of the structure of naming formulas in different regions in the 15th c.; 2) a comparative analysis of the repertoire of personal names with respect to the frequency, relations between “folk” names and the names of the Christian saints, differences in patterns of naming in rural and urban areas and in different social strata; and 3) an analysis of the most common constitutive roots and suffixes. Research goals include the development of digital tools, interactive maps which will visualise: 1) the frequency and extent of most common personal names; 2) the distribution of most common radices and suffixes. The results of the research will be presented to the public through research studies, participation in conferences, and organisation of a conference dedicated to historical anthroponymy.]]></summary_en></project><project>
<id>7204</id><title_hr><![CDATA[Uloga proteina Spartan u DNA replikaciji]]></title_hr><title_en><![CDATA[]]></title_en><user_id>7349</user_id><user_firstLast_name>Ivana Marinović Terzić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-4568</code><acronim><![CDATA[SprtnRep]]></acronim><duration>01.07.2018 - 24.04.2023</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Split School of Medicine]]></institution_en><team_members_id>25210</team_members_id><team_members_names><![CDATA[ Doktorand: Anja Ančić ]]></team_members_names><keywords_hr><![CDATA[Spartan, DVC1, DNA replikacija, DNA popravak, metaloproteazna domena, hepatocelularni karcinom ]]></keywords_hr><keywords_en><![CDATA[Spartan, DVC1, DNA replication, DNA repair, metalloprotease domain, hepatocellular carcinoma]]></keywords_en><summary_hr><![CDATA[Stabilnost kromosoma tijekom replikacije i popravka DNA je presudna za sprečavanje patološke transformacije stanica. Nedostatnosti DNA popravka uzrokuju razvojne anomalije, preuranjeno starenje (progeriju) i rak. Većina DNA oštećenja blokira napredovanje replikacijske viljuške, jer DNA polimeraza ne može prepoznati oštećene nukleotide. Na takvim mjestima, ubikvitinacija replikacijskog proteina PCNA, koji kao stezaljka kliže po DNA molekuli, pokreće mehanizam  translezijske DNA sinteze (TLS). Nedavno smo identificirali nasljednu mutaciju gena SPRTN (Spartan) kod tri bolesnika, koji su razvili progeroidni sindrom karakteriziran genomskom nestabilnosti i razvojem hepatocelularnog karcinoma (HCC) u mladosti. Druge grupe su pokazale da ja Spartan važan za aktivaciju TLS (Ghosal et al, 2012; Kim i sur, 2013). Naši rezultati pokazuju da Spartan igra važnu ulogu u normalnoj replikaciji DNA, sprečavajući replikacijski stres i održavajući stabilnosti genoma (Marinović-Terzić et al, 2014). U ovom projektu predlažemo da je Spartan metaloproteaza važna za uklanjanje kovalentno vezanih proteina i DNA, čime se omogućava napredovanje replikacijske viljuške.	Cilj ovog projekta je:1. Definirati funkciju Spartan domena,2. Odredite interakcijska svojstva / partnere proteina Spartan3. Opisati dinamiku procesa popravka DNA oštećenja u stanicama bez proteina SpartanVećina tehnika koje ćemo koristiti u ovom radu su uvriježene u našim laboratorijima: Western blot, IP, GST-pulldown, Imunofluorescentna mikroskopija, RNAi, SILAC bazirana masena spektrometrije i protočna citometrija. Koristit ćemo i jednu novu tehniku - CRISPR / Cas9 ciljano preuređivanje gena. Svi pokusi će se raditi na kulturama stanica. Ovaj projekt ima potencijal za generiranje vrlo zanimljivih rezultata i visoku vjerojatnost publiciranja u vrhunskim znanstvenim časopisima. Rezultati ovog projekta će bolje razjasniti specifičnu ulogu proteina Spartan u DNA replikaciji i održavanju genomske stabilnosti.]]></summary_hr><summary_en><![CDATA[The maintenance of chromosomal stability during DNA replication and repair is crucial for preventing patogenic transformation of a cell. Defects in DNA repair cause developmental abnormalities, premature aging, and cancer. Most types of DNA damage block the progression of replication forks, because DNA polymerases cannot recognize damaged nucleotides. At sites of stalled DNA replication fork, replication sliding clamp protein PCNA becomes ubiquitinated and thus initiates translesion DNA synthesis (TLS). Recently, we have identified germline mutations in SPRTN gene (Spartan) in three patients, who developed progeroid syndrome characterized by genomic instability and early onset hepatocellular carcinoma (HCC). Previously it was proposed that Spartan is important for activation of TLS (Ghosal et al, 2012; Kim et al, 2013). Our results show that Spartan plays an essential role in normal DNA replication by preventing DNA replication-stress and maintaining genome stability (Marinovic-Terzic et al, 2014). Here we propose that Spartan is a metaloprotease important for removal of DNA-protein crosslinks, thus enabling the progression of replication forks. Our goal in this project is to:1. Define the functions of Spartan’s domains, 2. Determine Spartans interacting properties/partners, and 3. Describe the dynamics of a DNA damage repair process in Spartan depleted cells. Most of the techniques we will use in this work are established procedures in our laboratories: Western blot, IP, GST-pull down, immunofluorescent microscopy, RNAi, SILAC based mas spectrometry and flow cytometry. One novel technique will be used as well – CRISPR/Cas9 targeted gene editing. All experiments will be performed using cultured cells. This project proposal has a potential to generate very interesting results with high possibility for publications in top scientific journals. Results of this project will help to better understand the specific role of Spartan in DNA replication and genome stability.]]></summary_en></project><project>
<id>7205</id><title_hr><![CDATA[Formalno rasuđivanje i semantike]]></title_hr><title_en><![CDATA[]]></title_en><user_id>21409</user_id><user_firstLast_name>Tin Perkov</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-6812</code><acronim><![CDATA[FORMALS]]></acronim><duration>12.10.2018 - 12.01.2020</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Učiteljski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Teacher Education]]></institution_en><team_members_id>23890</team_members_id><team_members_names><![CDATA[ Doktorand: Sebastijan Horvat ]]></team_members_names><keywords_hr><![CDATA[matematička logika, modalna logika, teorija modela, logika u računarstvu, formalno rasuđivanje]]></keywords_hr><keywords_en><![CDATA[mathematical logic, modal logic, model theory, logic in computer science, formal reasoning]]></keywords_en><summary_hr><![CDATA[Projekt će uspostaviti novu istraživačku grupu u području matematičke logike, s ciljem uspostave suradnje među istraživačima čiji dosadašnji rezultati su pretežno teorijski s istraživačima koji su se u dosadašnjem znanstvenom radu fokusirali na primjene. Stoga je naglasak projekta na međusobnoj komunikaciji i diseminaciji, kao i usavršavanju doktoranada koji će se od samog početka znanstvene karijere poticati da razviju ovaj interdisciplinarni pogled. Sadržajno, cilj projekta je međusobno obogaćivanje teorijske i primijenjene logike s naglaskom na primjene logike u računarstvu, ali i obratno, primjene računalnih alata u logičkom i matematičkom istraživanju. Drugi cilj je primjena logike u konkretnim problemima lingvistike ili, općenitije, kognitivnih i informacijskih znanosti, pa i interdisciplinarnih područja u kojima se preklapaju ekonomija i matematika (teorija igara, teorija društvenog izbora). Na prvi pogled vrlo formalna i teorijska disciplina, logika je izrazito primjenjiva, a iznenađuje primjena istih ili sličnih logičkih sistema, osobito modalne logike, u vrlo različitim područjima. Formalizacija donosi pojmovnu preciznost i jasnoću, što omogućuje sigurnost u dokazivanju novih spoznaja, ali i rasvjetljuje kompleksnost problema i otkriva nova pitanja koja u neformalnom rasuđivanju mogu ostati skrivena. Teorijski aspekti projekta obuhvaćaju: 1) istraživanje izražajne snage formalnih jezika metodama teorije modela, 2) adekvatnost i potpunost, odlučivost i složenost logičkih sistema, osobito modalne logike, 3) istraživanje mogućnosti razvoja apstraktne teorije formalnih semantika. Aspekti primjene su: 1) razvoj, istraživanje i formalizacija matematičkih modela za probleme drugih disciplina, 2) razvoj i implementacija algoritama, 3) otkrivanje veza među pitanjima iz prividno različitih područja preko srodnih formalizacija. Projekt predviđa interdisciplinarnu i međunarodnu suradnju.]]></summary_hr><summary_en><![CDATA[A new research group in mathematical logic will be established, with the aim of collaboration between researchers whose previous results were mainly in pure logic and those who previously focused on applications. The emphasis of the project is on mutual communication and dissemination, and training of doctoral students who will be encouraged to develop this interdisciplinary approach from the very beginning of their career. The goal of the project is mutual enrichment of pure and applied logic, with emphasis on applications of logic in computer science, and vice versa, the application of computational tools in logical and mathematical research. Another goal is to apply logic to specific problems of linguistics or, more generally, cognitive and information sciences, as well as interdisciplinary areas in which economics and mathematics overlap (game theory, social choice theory). Even though logic is at the first glance a formal and theoretical discipline, logic is also exceptionally applicable, and it is surprising to see applications of the same or similar formal systems, especially modal logics, in a variety of areas. Formalization brings conceptual precision, clarity and confidence. Formalization also provides new insights of the complexity of problems and allows for discovery of new issues that remain hidden in informal reasoning. The theoretical aspects of the project include: 1) exploring the expressive power of formal languages by methods of model theory, 2) soundness and completeness, decidability and complexity of formal systems, especially modal logics, 3) exploring the possibilities of developing an abstract theory of formal semantics. Application aspects are: 1) development, research and formalization of mathematical models for problems of other disciplines, 2) development and implementation of algorithms, 3) detection of links between seemingly unrelated domains through related formalizations. Interdisciplinary and international collaboration is planned.]]></summary_en></project><project>
<id>7216</id><title_hr><![CDATA[Timska adaptabilnost u razvoju inovativnih proizvoda]]></title_hr><title_en><![CDATA[Team Adaptability for Innovation-Oriented Product Development]]></title_en><user_id>4471</user_id><user_firstLast_name>Mario Štorga</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-7269</code><acronim><![CDATA[TAIDE]]></acronim><duration>01.11.2018 - 31.10.2022</duration><status>Završio</status><financ_value>121.441,37 eur</financ_value><scie_area_hr>Tehničke znanosti, Interdiciplinarne znanosti, Društvene znanosti, Prirodne znanosti, Humanističke znanosti, </scie_area_hr><scie_area_en>Technological sciences, Interdisciplinary scientific area, Social sciences, Natural sciences, Humanities, </scie_area_en><scie_field_hr>Interdisciplinarne tehničke znanosti, Matematika, Računarstvo, Strojarstvo, Informacijske znanosti, Kognitivna znanost, Projektni menadžemnt, Interdisciplinarne društvene znanosti, </scie_field_hr><scie_field_en>Interdisciplinary technological sciences, Mathematics, Computer sciences, Mechnical engineering, Information sciences, Cognitive science, Project management, Interdisciplinary social sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>6397, 19022, 17795, 24043, 24142, 24150, 24138, 863804, 27167, </team_members_id><team_members_names><![CDATA[Stanko Škec, Tomislav Martinec, Marija Majda Perišić, Nikola Horvat, John Gero, Peter Törlind, Philip Cash Cash, Fanika Lukačević, Ivan Čeh, ]]></team_members_names><keywords_hr><![CDATA[timski rad, inovativni razvoj proizvoda, adaptabilnost, simulacije, eksprimentalno istraživanje u konstruiranju]]></keywords_hr><keywords_en><![CDATA[teamwork, innovative product development, adaptability, simulation, experimental design research]]></keywords_en><summary_hr><![CDATA[Inženjerski timovi se često koriste u dinamičnom okruženju koje zahtijevaa adaptaciju I promjenu zbog različitih utjecajnih faktora; timovi se moraju prilagoditi promjenama tržišnih trendova, tehnologije ili ograničenjima resursa. Kako se istraživačko područje koje se bavi inženjerskim timovima razvija, istraživanje u ovom području sve više zahtjeva interdisciplinarne pristupe za razumijevanje, modeliranje i unapređenje uloge koje timovi imaju u razvoju proizvoda. S obzirom na to da brojni faktori koji utječu na timski rad ovise o raspoloživom kontekstu aktivnosti, predviđanje performansi timova koji rade licem-u-lice ili u virtualnoj okolini je iznimno zahtjevno, te je očiti nedostatak istraživačkih studija u tom području.Cilj predloženog istraživanja je razvoj istraživačkog i konceptualnog okvira za eksperimentalno istraživanje inženjerskih timova (licem-u-lice kao i u virtualnoj okolini) koji rade na razvoju inovativnih proizvoda. Predloženi projekt će doprinijeti teoriji i praksi kroz interdisciplinarno istraživanje te će se nadograditi na rezultate trenutno aktivnog HRZZ projekta MINMED. Tijekom projekta kao istraživačka metodologija će se koristiti metodologija istraživanja u znanosti o konstruiranju, dok će metode eksperimentalnog istraživanje u konstruiranju biti glavna istraživačka paradigm.Od rezultata projekta se očekuje da ocrtaju kako empirijsko istraživanje i računalne simulacije timskog rada mogu dovesti do boljeg razumijevanja, modeliranja, I unapređenja timska adaptabilnosti kao jednog od glavnih svojstava timskog rada koje je važno za inovativnost. Računalni alati koji će nastati kao rezultat istraživanja trebali bi omogućiti istraživačima te ljudima iz industrije korištenje računalnih simulacija za razumijevanje uloge koju različiti uzroci poremećaja u radu imaju na timsku adaptabilnost.Istraživanje će se izvoditi u multidisciplinarnom okruženju koje uključuje istraživače, ali i istraživačku infrastrukturu u Hrvatskoj, Danskoj, Švedskoj i SAD.]]></summary_hr><summary_en><![CDATA[Engineering teams are often used in dynamic environments that require adaptation and constant change due to external and internal circumstances; they have to adjust to changes in market trends, and adapt to changing technologies or resources constraints. As the research field concerning engineering teams develops, it continues to require interdisciplinary approaches to understand, model and improve the role of the teamwork in product development. However, since there are numerous factors influencing teamwork depend on time and context, understanding and predicting face-to-face and virtual team performance is exceptionally challenging, and there are insufficient research studies.The goal of the proposed research project is the development of the research and conceptualisation framework for experimental studies of engineering teams (both face-to-face and virtual) within innovation-oriented product development projects. The proposed project will contribute to both the theory and practice by bringing together interdisciplinary research and it will build on the results of the ongoing CSF project MINMED. During the project, the Design Science Research framework will be applied as the research methodology, while experimental design research will be the primary research paradigm. The results are expected to delineate how empirical research and computational simulations can lead to better understanding, modelling, reflection on and improvement of team adaptability as one of the most important emergent properties of the engineering teams in relation to innovation. The resulting computational tools should enable researchers and practitioners from the industry to utilise simulations to understand the role that the different types of disruption triggers have on the resulting team adaptation.The research will be conducted by a multidisciplinary research group including the researchers and research infrastructure for experimentation from Croatia, USA, Denmark and Sweden.]]></summary_en></project><project>
<id>7228</id><title_hr><![CDATA[Efikasni algoritmi za robusnu diskretnu optimizaciju]]></title_hr><title_en><![CDATA[Efficient algorithms for robust discrete optimization]]></title_en><user_id>11204</user_id><user_firstLast_name>Robert Manger</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-5591</code><acronim><![CDATA[RoDiOpt]]></acronim><duration>22.10.2018 - 21.10.2022</duration><status>Završio</status><financ_value>27.871,79 eur</financ_value><scie_area_hr>Prirodne znanosti, Tehničke znanosti, </scie_area_hr><scie_area_en>Natural sciences, Technological sciences, </scie_area_en><scie_field_hr>Matematika, Računarstvo, </scie_field_hr><scie_field_en>Mathematics, Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>12413, 12411, 23346, 28984, </team_members_id><team_members_names><![CDATA[Goranka Nogo, Krunoslav Puljić, Ana Klobučar, Marko Špoljarec, ]]></team_members_names><keywords_hr><![CDATA[robusna optimizacija, diskretna optimizacija, oblikovanje i analiza algoritama, heuristike, meta-heuristike]]></keywords_hr><keywords_en><![CDATA[robust optimization, discrete optimization, design and analysis of algorithms, heuristics, meta-heuristics]]></keywords_en><summary_hr><![CDATA[Primjerak problema diskretne optimizacije zadaje se točnim vrijednostima parametara unutar njegove funkcije cilja i u njegovim ograničenjima. Te vrijednosti u stvarnom životu obično je teško odrediti – tada govorimo o neizvjesnosti kod formulacije problema.Suvremeni pristup u izlaženju na kraj sa spomenutom neizvjesnošću naziva se robusna optimizacija. U skladu s tim pristupom definira se skup scenarija – svaki od njih zadaje jednu moguću kombinaciju vrijednosti parametara. Promatraju se samo ona rješenja koja su dopustiva za sve scenarije. Na neki se način mjeri ponašanje rješenja ovisno o scenariju. Kao optimalno rješenje u robusnom smislu bira se ono čije je najgore ponašanje, mjereno na cijelom skupu scenarija, najbolje među svim rješenjima.Makar se konvencionalne varijante nekih problema diskretne optimizacije mogu riješiti u polinomijalnom vremenu, robusne varijante istih problema obično su NP-teške. To znači da pronalaženje efikasnih algoritama za robusne varijante predstavlja zanimljivu istraživačku temu. U ovom trenutku nema baš puno algoritama takve vrste koji bi se mogli smatrati prikladnima za primjene u stvarnom životu.Cilj ovog projekta je razviti efikasne i u praktičnom smislu upotrebljive algoritme za robusne varijante sljedećih problema diskretne optimizacije: optimalni putovi u grafovima, optimalni tokovi u mrežama, maksimalni težinski nezavisni skupovi, trgovački putnik i slični problemi. Promatrat će se varijante gdje je skup scenarija konačan i eksplicitno zadan. Naglasak će biti na heurističkim ili meta-heurističkim rješenjima.Svaki od algoritama analizirat će se sa stanovišta korektnosti, preciznosti, odnosno vremenske složenosti. Algoritmi će se implementirati kao softver, vrednovati na velikim primjercima problema te učiniti dostupnima drugim istraživačima preko repozitorija na webu. Postignuti rezultati dokumentirat će se u znanstvenim člancima i objaviti u odgovarajućim časopisima.]]></summary_hr><summary_en><![CDATA[An instance of a discrete optimization problem is specified by exact values of parameters within its objective function and its constraints. In real-world situations parameter values are often hard to determine - then we speak about uncertainty in problem formulation.A state-of-the-art approach to address the mentioned uncertainty is called robust optimization. According to this approach, a set of scenarios is defined - each of them specifies a possible combination of parameter values. Only those solutions are considered that are feasible for all scenarios. The behaviour of any solution under any scenario is measured in some way. As the optimal solution in the robust sense, the one is chosen whose worst behaviour, measured over the whole set of scenarios, turns out to be the best among all solutions.Although conventional variants of some discrete optimization problems can be solved in polynomial time, robust variants of the same problems are usually NP-hard. Consequently, finding efficient algorithms for robust variants is a challenging research topic. At this moment, there are not many algorithms of that kind that can be regarded as suitable for real-world applications.The aim of this project is to develop efficient and practically relevant algorithms for robust variants of the following discrete optimization problems: optimal paths in graphs, optimal flows in networks, maximum weighted independent sets, traveling salesman and similar problems. Variants will be considered where the set of scenarios is finite and given explicitly. Emphasis will be put on heuristic or meta-heuristic solutions.Each algorithm will be analysed in terms of correctness, precision and time complexity. The algorithms will be implemented in software, evaluated on large benchmark problem instances and made available over a web repository to other researchers.  All obtained results will be documented in research papers and published in appropriate journals. ]]></summary_en></project><project>
<id>7229</id><title_hr><![CDATA[Uloga oksidativnog stresa i opiorfina u temporomandibularnim poremećajima]]></title_hr><title_en><![CDATA[]]></title_en><user_id>612</user_id><user_firstLast_name>Iva Alajbeg</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-5137</code><acronim><![CDATA[ROStrO-TMD]]></acronim><duration>16.07.2018 - 15.10.2020</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Dentalna medicina, </scie_field_hr><scie_field_en>Dental medicine, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Stomatološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Dentistry]]></institution_en><team_members_id>21042</team_members_id><team_members_names><![CDATA[ Doktorand: Ema Vrbanović ]]></team_members_names><keywords_hr><![CDATA[temporomandibularni poremećaji, oksidativni stres, opiorfin, orofacijalna bol, ELISA, HPLC MS, slina]]></keywords_hr><keywords_en><![CDATA[temporomandibular disorders, oxidative stress,  opiorphin, orofacial pain, ELISA, HPLC MS, saliva]]></keywords_en><summary_hr><![CDATA[Temporomandibularni poremećaji (TMP) kronični su bolni poremećaji koji zahvaćaju čeljusni zglob, žvačne mišiće i okolna tkiva, s prevalencijom u populaciji od 3,6 do 7%. Patološki supstrat uglavnom izostaje, a uzrok je često nepoznat. Psihološki i mehanički stresni čimbenici mogu doprinijeti nastanku oksidativnog stresa (OS) i rezultirati TMP-om.Cilj je kvantificirati markere OS, totalni antioksidativni kapacitet (TAK) te nedavno izolirani endogeni peptid opiorfin (OP) u slini pacijenata s TMP-om i usporediti ih s kontrolnom skupinom. Kako kronična izloženost stresu može uzrokovati hiperalgeziju koja nastaje kao posljedica odgovora na stres u hipotalamičko-hipofizno-adrenalnoj (HHA) osi, cilj je istražiti ovaj mehanizam uspoređujući OP i markere OS s razinom salivarnog kortizola (SK).Hipoteze: OS ima ulogu u nastanku i održavanju TMP-a, stoga će markeri OS u slini rasti i/ili će se TAK smanjiti; opiorfin utječe na orofacijalne bolne sindrome kao što je TMP i njegove vrijednosti u slini će se razlikovati između bolesnika s TMP-om i kontrole. Poremećena HHA osovina je u podlozi povećanog OS i promjena razina OP u bolesnika s TMP-om.U 50 bolesnika s TMP-om (dijagnosticiranih pomoću kriterija i MRI nalaza) i 50 kontrolnih ispitanika sakupit će se slina. Za određivanje markera OS koristit će se ELISA sa spektrofotometrijom. Razine OP mjerit će se HPLC-MS/MS metodom koju smo sami razvili. Za određivanje SK koristit će se elektrokemiluminiscentna imunokemijska metoda s prethodnom ekstrakcijom.Pacijenti s TMP-om će biti randomizirani u 2 skupine (1:stabilizacijska udlaga + placebo tablete; 2:placebo udlaga + 1g vitamina C). Mjerenja će se ponoviti nakon 3 i 6 mjeseci. Praćenje OP, OS markera i SK tijekom tog razdoblja će, ovisno o promjenama simptoma TMP-a, dodatno rasvijetliti predloženi podliježeći mehanizam. Novi pristup u objašnjavanja neuroendokrinih mehanizama u TMP-u i uporaba sline kao neinvazivno pristupačne dijagnostičke tekućine predstavlja značajan napredak. ]]></summary_hr><summary_en><![CDATA[Temporomandibular disorders (TMD) are chronic painful conditions involving joints, masticatory muscles and associated tissues that affect 3.6-7% of the population. Observable pathology is mostly absent, and the cause is unknown. Psychological and mechanical stress factors could contribute to oxidative stress (OS) and lead to TMD. Aims are to quantify salivary OS markers and total antioxidant capacity (TAC) and to quantify recently isolated endogenous peptide opiorphin (OP) in saliva of TMD patients and compare them to controls. As chronic exposure to stress may cause hyperalgesia as a result of the stress response in the hypothalamic-pituitary-adrenal (HPA) axis, aim is to test this as an underlying mechanism by correlating OP and OS markers to salivary cortisol (SC) levels. Hypotheses: OS has a role in TMD onset and maintenance, thus salivary markers of OS will increase and/or TAC will decrease; OP influences orofacial pain syndromes, such as TMD, and its salivary level will differ between TMD patients and controls. Disbalanced HPA axis underlies the increase of OS and OP level changes in TMD patients.Saliva of 50 TMD patients (diagnosed by validated diagnostic criteria and MRI) and 50 controls will be collected. OS markers will be assessed by ELISA with spectrophotometric detection and by spectrophotometric reagent kits. OP levels will be measured by HPLC-MS/MS method, developed by team members. The electrochemiluminescence immunoassay ECLIA will be used for measuring SC.TMD patients will be randomized in 2 treatment groups (1:stabilization splint + placebo pills; 2:placebo splint + 1g of vitamin C). Measurements will be repeated after 3 and 6 months of treatment. Monitoring of OP, OS markers and SC during that period will, in relation to TMD symptoms changes, further elucidate underlying proposed mechanism.Novel approach to understanding neuroendocrine mechanisms in TMD and use of saliva as non-invasively available biofluid represent significant advances.]]></summary_en></project><project>
<id>7230</id><title_hr><![CDATA[Retrodigitalizacija i interpretacija hrvatskih gramatika do ilirizma]]></title_hr><title_en><![CDATA[Retro-digitization and Interpretation of Croatian Grammar Books before Illyrism]]></title_en><user_id>7861</user_id><user_firstLast_name>Marijana Horvat</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-3585</code><acronim><![CDATA[RETROGRAM]]></acronim><duration>25.11.2019 - 24.11.2023</duration><status>Završio</status><financ_value>39.687,57 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filologija, Interdisciplinarne humanističke znanosti, </scie_field_hr><scie_field_en>Philology, Interdisciplinary humanities, </scie_field_en><institution_hr><![CDATA[Institut za hrvatski jezik]]></institution_hr><institution_en><![CDATA[Institute of Croatian Language]]></institution_en><team_members_id>12671, 22807, 12754, 23437, 23740, 8629, 12874, 4025, 23565, 23646, </team_members_id><team_members_names><![CDATA[Petra Bago, Ivana  Lovrić Jović, Ana Mihaljević, Sanja Perić Gavrančić, Diana Stolac, Ljiljana  Šarić, Barbara Štebih Golub, Tamara Tvrtković, Ivo Pranjković, Martina Kramarić, ]]></team_members_names><keywords_hr><![CDATA[retrodigitalizacija, digitalna humanistika, hrvatska jezična baština, dopreporodne gramatike, portal hrvatskih gramatika, gramatikografija]]></keywords_hr><keywords_en><![CDATA[retro-digitization, digital humanities network, Croatian linguistic heritage, Pre-standard Croatian Grammars, portal of Croatian grammar books, gramma]]></keywords_en><summary_hr><![CDATA[U Hrvatskoj se tek stvaraju retrodigitalizirani resursi. Ne postoji repozitorij koji bi sadržavao digitalizirane i pretražive stare hrvatske gramatike ni model koji bi se na njih mogao primijeniti, kao ni sustavno provedena istraživanja u tom području. Ovim se projektom namjerava promijeniti takvo stanje. Retrodigitalizacija se odnosi na prijenos tiskanoga medija u računalno čitljiv i pretraživ tekst. Ona u ovom projektu obuhvaća i višerazinsko označivanje transkribiranoga/prevedenoga teksta hrvatskih dopreporodnih gramatika i njihovo povezivanje s faksimilima. Projektom je obuhvaćeno 17 gramatika, štokavskih i kajkavskih, objavljenih do hrvatskoga narodnog preporoda. Priredit će se faksimili svih 17 gramatika. Tekstualnim digitalnim izdanjem bit će predstavljeno 13 gramatika, na kojima će se provoditi kodiranje segmenata gramatičkoga teksta i morfoloških paradigma TEI oznakama, dok će se iz četiriju gramatičkih priručnika samo ispisivati hrvatsko nazivlje. Cilj je izraditi portal hrvatskih gramatika do ilirizma s faksimilima izvornika, metapodatcima i tekstovima transkripcija/prijevoda odabranih gramatika, omogućiti pretraživost na morfološkoj razini, istražiti i opisati gramatike, izraditi indeks hrvatskoga dopreporodnog gramatičkog nazivlja. Planirano je održavanje znanstvenoga skupa o hrvatskoj dopreporodnoj gramatikografiji u europskom kontekstu i objava e-zbornika radova. Projektom se nastoje intenzivirati istraživanja dopreporodne gramatičke građe, upotpuniti spoznaje o morfološkom razvoju hrvatskoga jezika u dopreporodnom razdoblju i spoznaje o razvoju normativnoga opisa te ponuditi znanja primjenom modernih lingvističkih disciplina (kognitivni pristup). Zaključci o izgradnji hrvatskoga gramatičkog modela temeljit će se i na raščlambi strukture latinskih gramatika te će promatrani korpus gramatika predmet interesa usmjeriti i na latinistička istraživanja.Portal bi bio otvorenoga pristupa, zamišljen za trajni daljnji razvoj i rast nakon dovršetka projekta.]]></summary_hr><summary_en><![CDATA[Creation of retro-digitized resources in Croatia is still in beginnings. There is no repository that would contain digitized and searchable database of old Croatian grammars, no model that could be applied, no systematically conducted research in the field. The aim of the proposed project is to change this situation. The retro-digitization implies the transfer of printed media to computer readable and searchable text. It also includes multilevel mark-up of transcribed/translated grammar text and its connection with facsimiles. The project plan covers 17 grammar books published before the Illyrian movement. Grammars will be represented by facsimiles, 13 of them by digital text editions. Digitization process will include mark-up of grammar text segments and morphological paradigms by TEI tags and will be conducted on transcriptions/translations. Four grammars will serve for extraction of linguistic terminology. The main aim of the project is to create a web portal of Croatian grammar books before Illyrism, which would include facsimiles with basic information, transcription/translation, an index of linguistic terminology. The portal will be equipped by thematic searching possibilities on the morphology level. An international scholarly conference on pre-standard Croatian grammaticography in European context is envisaged and online publishing of a conference proceeding on the project web page. The objective is to intensify research activities and interpretation of the Croatian pre-standard grammars within the scope of modern linguistic disciplines (cognitive approach), to complete existing knowledge about the morphological development of the Croatian language, its normative descriptions and developement of linguistic terminology in the pre-standard period. Conclusions on the formation of the Croatian language grammar model will also be based on analysis of the Latin language grammar structure. The result will be an open access web portal available for further upgrade.]]></summary_en></project><project>
<id>7231</id><title_hr><![CDATA[Od površinskih svojstava stanica alga do pokazatelja stresa u vodenim ekosustavima]]></title_hr><title_en><![CDATA[From algal cell surface properties to stress markers for aquatic ecosystems]]></title_en><user_id>513</user_id><user_firstLast_name>Nadica Ivošević DeNardis</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-5840</code><acronim><![CDATA[CELLSTRESS]]></acronim><duration>01.12.2018 - 30.11.2022</duration><status>Završio</status><financ_value>116.172,27 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Interdisciplinarne prirodne znanosti, Fizika, Kemija, Biologija, </scie_field_hr><scie_field_en>Interdisciplinary natural sciences, Physics, Chemistry, Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>6101, 19526, 5786, 23474, 23473, 23674, 25737, 17752, </team_members_id><team_members_names><![CDATA[Tea Mišić Radić, Petar Žutinić, Tomislav Vuletić, Joanna Zemła, Malgorzata Lekka, Kobiela Tomasz, Nives Novosel, Maja Levak Zorinc, ]]></team_members_names><keywords_hr><![CDATA[adhezija, AFM, alge, površinska svojstva, salinitet, stanična nanomehanika, stanični stres, temperatura, vodeni ekosustavi]]></keywords_hr><keywords_en><![CDATA[adhesion, AFM, algae, aquatic ecosystems, cell nanomechanics, cell stress, salinity, surface properties, temperature]]></keywords_en><summary_hr><![CDATA[Razumijevanje osjetljivosti različitih trofičkih razina ključno je za predviđanje utjecaja klimatskih promjena na zajednice u vodenom okolišu. CELLSTRESS projekt fokusiran je na morske mikroalge koje imaju ključnu ulogu u globalnoj primarnoj proizvodnji, glavnim biogeokemijskim ciklusima te predstavljaju temelj hranidbenoga lanca u vodenom okolišu. Odgovor stanica alga pouzdan je pokazatelj promjena u ekosustavu budući da zbog kratkoga životnog ciklusa brzo reagiraju na varijacije u okolišu. Cilj projekta je povezivanje staničnoga odgovora alga (u smislu površinskih svojstava i fiziološkoga odgovora) na glavne abiotičke stresore (temperaturu i salinitet) radi boljega razumijevanja preživljavanja i strategija prilagodbi alga u vodenim sustavima. Odabrani modelni organizmi jesu stanice alga različitih svojstava staničnih barijera, pokretljivosti i tolerancije na salinitet. Koristit ćemo komplementarne biofizičke površinske metode utemeljene na analizi pojedinačnih stanica (mikroskopija atomskih sila, kvarcna mikrovaga i elektrokemijska metoda). S obzirom na to da svaka metoda ispituje različite aspekte površinskih svojstava stanica, zajedno mogu pružiti jedinstveno razumijevanje te proširiti skalu karakterizacije stanične površine od mikro do nano razine, što je važno za razumijevanje ponašanja stanica u uvjetima stresa u morskom okolišu. Projekt CELLSTRESS mogao bi znatno doprinijeti sadašnjim spoznajama u biofizici stanica alga na temeljnoj razini. Razumijevanje površinskih svojstava stanica može pomoći u razjašnjavanju međudjelovanja mehanike i biokemije koja regulira funkcionalno ponašanje stanica. Rezultati projekta utjecat će potencijalno na buduće definiranje smjernica za zaštitu okoliša uključivanjem nanomehaničke studije staničnoga stresa u skup metoda za  ocjenu stanja ekosustava koji se proučava.]]></summary_hr><summary_en><![CDATA[A key to forecast the impact of climate change on aquatic communities is an understanding of fragility of different trophic levels in the ecosystem. The CELLSTRESS project focuses on marine microalgae as the globally important primary producers, drivers of essential biogeochemical cycles, as well as the basis of aquatic food web. Changes in algal cell responses can be an accurate marker of ecosystem perturbations, since microalgae quickly respond to subtle environmental variations due to short life cycles. The objective is to relate algal cell response (in terms of surface properties and physiological behaviour) to main abiotic environmental stressors (temperature and salinity) in order to better understand viability and adaptation strategies of algal populations in aquatic systems. Selected model organisms are algal species of varied cellular barrier properties, cell motility and salinity tolerance. We will use complementary biophysical surface methods capable of studying individual cells (atomic force microscopy, quartz crystal microbalance and electrochemical method). While each method probes a different aspect of cell surface properties, together they can provide a more unified understanding and extend the scale of cell surface characterization from micro to nano level, which is of importance to understand cell behaviour under environmental stress conditions. The CELLSTRESS project could substantially contribute to the present knowledge in the biophysics of algal cell on the fundamental level. Understanding of the cell surface properties may help to elucidate the interplay between mechanics and biochemistry that regulates functional cell behaviour. The project results may potentially impact the future environmental protection guidelines by inclusion of nanomechanical cell-stress study in the portfolio of methods to evaluate state of the ecosystem under consideration.]]></summary_en></project><project>
<id>7236</id><title_hr><![CDATA[Mikrolokalni defektni alati u parcijalnim diferencijalnim jednadžbama]]></title_hr><title_en><![CDATA[Microlocal defect tools in partial differential equations]]></title_en><user_id>58</user_id><user_firstLast_name>Nenad Antonić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-2449</code><acronim><![CDATA[MiTPDE]]></acronim><duration>01.11.2018 - 15.03.2023</duration><status>Završio</status><financ_value>130.333,80 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>72, 637, 1460, 17819, 23449, 25426, 864981, 865388, </team_members_id><team_members_names><![CDATA[Marko Erceg, Ivan Ivec, Darko Mitrovic, Andrej Novak, Ivana Vojnović, Matko Grbac, Sandeep Kumar Soni, Milosz Krupski, ]]></team_members_names><keywords_hr><![CDATA[mikrolokalne defektne mjere, H-mjere, H-distribucije, poluklasične mjere, kompaktnost kompenzacijom, zakoni sačuvanja, Friedrichsovi sustavi]]></keywords_hr><keywords_en><![CDATA[microlocal defect measures, H-measures, H-distributions, semiclassical measures, compactness by compensation, conservation laws, Friedrichs system]]></keywords_en><summary_hr><![CDATA[Parcijalne diferencijalne jednadžbe su nesumnjivo jedan od najuspješnijih matematičkih modela za razumijevanje različitih procesa, ne samo u fizici kontinuuma, nego i u drugim znanstvenim i inženjerskim disciplinama. Premda ne postoji opća temeljna teorija parcijalnih diferencijalnih jednadžbi, usvojena je klasa metoda temeljenih na različitim pojmovima slabe konvergencije, koja je primjenjiva na rješavanje širokih klasa parcijalnih diferencijalnih jednadžbi, kao i na proučavanje drugih relevantnih pitanja, bilo intrinsičnih samoj toj teoriji, bilo vezanih uz njezinu primjenu u drugim područjima znanosti i tehnologije. Kompaktnost kompenzacijom i Youngove mjere, razvijeni skoro prije pola stoljeća, su alati razvijeni za bolje razumijevanje što se događa pri prijelazu na limes. Mikrolokalni defektni alati, poput mikrolokalnih defektnih mjera (ili H-mjera), poluklasičnih mjera, jednoskalnih H-mjera, H-distribucija i njihovih inačica, su alati koji se u novije vrijeme razvijaju za istu svrhu. Njihov daljnji razvoj i primjene u području parcijalnih diferencijalnih jednadžbi je glavni cilj istraživanja na ovom projektu. Posebno ćemo proučavati širenje gustoće mikrolokalne energije za neke jednadžbe, kao i dobru postavljenost i numeričko rješavanje heterogenih zakona sačuvanja sa stohastičkom desnom stranom, ili bez nje, za što bi odgovarajuća inačica mikrolokalnog defektnog alata trebala biti konstruirana i primijenjena. Među jednadžbama koje nas zanimaju su i one koje mijenjaju tip (na primjer, zbog visoke heterogenosti permeabilnosti kod prijenosnih procesa), a koje uzrokuju posebne poteškoće. Drugi način proučavanja takvih jednadžbi je njihov zapis u obliku Friedrichsovog sustava, što je klasa sustava prvog reda koja obuhvaća većinu linearnih jednadžbi matematičke fizike, poput klasičnih eliptičkih, paraboličkih i hiperboličkih jednadžbi, ali također i jednadžbe koje mijenjaju tip. Istovremeno, ti sustavi su vrlo pogodni za numeričku analizu.]]></summary_hr><summary_en><![CDATA[Partial differential equations are certainly one of the most successful mathematical models for understanding various processes not only in continuum physics, but in other branches of sciences and engineering. While there is no general core theory of partial differential equations, a class of methods based on various notions of weak convergence has emerged, being applicable for solving large classes of partial differential equations as well as investigating other relevant questions, either intrinsic to this theory, or pertaining to its applications in other fields of science and technology. Compactness by compensation and Young measures were the tools for better understanding of what happens on the limit developed almost half a century ago. Microlocal defect tools, like microlocal defect measures (H-measures), semiclassical measures, one-scale H-measures, H-distributions, and their variants, are the tools being developed recently for the same purpose. Their further development, and applications in the field of partial differential equations is the primal goal of the research within this project. We shall study, in particular, the propagation of microlocal energy density of certain equations, as well as the well-posedness and numerical solutions of heterogeneous conservation laws with or without a stochastic forcing, for which certain variant of microlocal defect tools should be constructed and applied. Among all equations of our interest, there are also equations that change their type (e.g. due to a high heterogeneity of the permeability in transport processes), which cause particular difficulties. Another way to study such equations is by re-writingthem in the form of Friedrichs systems, a class of first order systems which encompasses most of the linear equations of mathematical physics, like classical elliptic, parabolic and hyperbolic equations, but also the equations that change their type. At the same time they are quite convenient for numerical analysis.]]></summary_en></project><project>
<id>7239</id><title_hr><![CDATA[Application of Nanobiotechnology for Nutritional Supplementation with Selenium]]></title_hr><title_en><![CDATA[Primjena nanobiotehnologije za suplementaciju hrane sa selenom]]></title_en><user_id>1258</user_id><user_firstLast_name>Tomislav Vinković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-8119</code><acronim><![CDATA[NutriNTENSe]]></acronim><duration>01.01.2019 - 31.12.2022</duration><status>Završio</status><financ_value>132.576,81 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, Biotehnologija, Interdisciplinarne biotehničke znanosti, </scie_field_hr><scie_field_en>Agriculture, Biotechnology, Interdisciplinary biotechnical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Fakultet agrobiotehničkih znanosti Osijek]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Agrobiotechnical Sciences in Osijek]]></institution_en><team_members_id>3133, 2649, 1390, 21380, 22513, 22492, 23751, 24109, 7747, 26256, 28910, 855872, 858396, 3927, 865170, </team_members_id><team_members_names><![CDATA[Petra Turčić, Blanka Tariba Lovaković, Ana Marija Marjanović, Kristina Radić, Ivna Štolfa Čamagajevac, Ana Vuković, Monika Tkalec, Michalke Bernhard, Zdenko Lončarić, Emerik Galić, Boris Ravnjak, Dejan Bošnjak, Lucija Galić, Dubravka Vitali Čepo, Nikolina Golub, ]]></team_members_names><keywords_hr><![CDATA[selen, biofortifikacija, nanobiotehnologija, povrće, suplementacija hrane, prehrambeni otpad]]></keywords_hr><keywords_en><![CDATA[selenium, biofortification, nanobiotechnology, vegetables, nutritional supplementation, food waste]]></keywords_en><summary_hr><![CDATA[Selen (Se) je bitan mikroelement koji igra važnu ulogu u metabolizmu i mnogim drugim vitalnim funkcijama. Zbog svoje zaštitne aktivnosti tijekom imunološkog odgovora te kod karcinoma, Se se koristi kao dodatak prehrani. Budući da su biljke glavni izvor Se za ljude i životinje, različite strategije poput biofortifikacije i korištenja biljnih ekstrakata se koriste za razvoj prehrambenih dodataka na bazi Se. Biološka raspoloživost selena varira ovisno o nekoliko čimbenika, uključujući kemijski oblik Se, druge hranjive komponente u hrani, fiziološki status i status Se u organizmu. Glavne zapreke u postizanju optimalnog unosa Se su visoko varijabilni sadržaj u različitim vrstama hrane i uska sigurnosna granica unosa različitih Se oblika. Nanotehnologija omogućuje primjenu selenovih nanočestica (SeNPs), koje posjeduju jaču antioksidativnu aktivnost i nižu toksičnost u odnosu na druge oblike Se. NutriNTENSe projekt ima za cilj istražiti djelotvornost i sigurnost inovativnih nutraceutika i funkcionalne hrane na bazi SeNPs primjenom nanobiotehnoloških metoda. To će se postići razvojem dviju inovativnih klasa Se-nutraceutika: funkcionalnog biofortificiranog povrća sa SeNPs (FBVegs) i Se-nanoceutika (SeNCes) korištenjem ekstrakata prehrambenog otpada za biogenu sintezu SeNPs. Oba tipa Se-nutraceutika bit će podvrgnuta in vitro i/ili in vivo ispitivanjima kako bi se istražila njihova biokompatibilnost, sigurnost, farmakokinetička svojstva i farmakološka aktivnost u usporedbi sa selenatom i/ili kemijski sintetiziranim SeNPs. Osim toga, procijeniti će se moguće sinergističko djelovanje biogenih SeNPs i specifičnih bioaktivnih spojeva iz NutriNTENSe biljaka ili ekstrakata. Rezultati dobiveni NutriNTENse projektom biti će od velike koristi za potrošače, poljoprivredne proizvođače i prehrambenu industriju kao krajnje korisnike ishoda projekta. Treba istaknuti da NutriNTENse ima zeleni karakter s ciljem povećanja primjene zdravih i ekološki prihvatljivih proizvoda.]]></summary_hr><summary_en><![CDATA[Selenium (Se) is an essential trace element playing important role in metabolism and many other vital functions. Due to its protective activity in immune response and cancer, it is widely used as a diet supplement. As plants are the main dietary source of Se for humans and animals, different strategies such as biofortification and plant-based extracts are used to develop Se dietary supplements. Selenium bioavailability varies depending on several factors including chemical form of Se, other dietary components, physiological status and selenium status of the organism. The major obstacles in achieving optimal Se intake are highly variable Se content in different food types and narrow safety margin of supplemental Se forms. Nanotechnology enables application of selenium nanoparticles (SeNPs), due to their enhanced antioxidant activities and lower toxicity as compared to other Se forms. NutriNTENSe project aims to investigate the efficacy and safety of innovative SeNPs-based nutraceuticals and functional food using nanobiotechnological tools. This will be achived by following development of two innovative classes of Se-nutraceuticals: functional SeNPs biofortified vegetables (FBVegs) and Se-nanoceuticals (SeNCes) using food waste extracts for biogenic synthesis of SeNPs. Both types of Se-nutraceuticals will be subjected to in vitro and/or in vivo testings to investigate their biocompatibility, safety, pharmacokinetic properties and pharmacological activity compared to selenite and chemically synthesized SeNPs. In addition, possible synergistic action of biogenic SeNPs and specific bioactive compounds found in NutriNTENSe plants and extracts will be evaluated. Results obtained within NutriNTENse will be of great interest for consumers, agricultural producers and food industry as final beneficiaries of project outcomes. It should be highlighted that NutriNTENse is green project aimed to increase implementation of healthy and environment friendly products.]]></summary_en></project><project>
<id>7244</id><title_hr><![CDATA[Od terena do nasada: karakteristike i prilagodljivost na stres prirodnih populacija pitomoga kestena i maruna]]></title_hr><title_en><![CDATA[From field to orchard: wild sweet chestnut populations and marron characteristics and adaptability to stress]]></title_en><user_id>975</user_id><user_firstLast_name>Marilena Idžojtić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-1295</code><acronim><![CDATA[CHESTNUT AND MARRON]]></acronim><duration>16.10.2018 - 15.10.2022</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Biotehničke znanosti, Prirodne znanosti, </scie_area_hr><scie_area_en>Biotechnical sciences, Natural sciences, </scie_area_en><scie_field_hr>Šumarstvo, Biologija, Prehrambena tehnologija, </scie_field_hr><scie_field_en>Forestry, Biology, Food technology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet šumarstva i drvne tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Forestry and Wood Technology]]></institution_en><team_members_id>757, 12402, 12710, 12599, 770, 2506, 761, 4570, 27583, 28741, </team_members_id><team_members_names><![CDATA[Igor Poljak, Vibor Roje, Damir Drvodelić, Ivan Perković, Zlatko Liber, Marin Ježić, Mirna  Ćurković Perica, Ines Panjkota Krbavčić, Antonio  Vidaković, Katarina Tumpa, ]]></team_members_names><keywords_hr><![CDATA[pitomi kesten, Castanea sativa, marun, raznolikost, adaptabilnost, epigenetika, rak kestenove kore, Cryphonectria parasitica, otpornost, sjemenske zon]]></keywords_hr><keywords_en><![CDATA[sweet chestnut, Castanea sativa, marron, variability, adaptability, epigenetics, chestnut blight, Cryphonectria parasitica, resistance, seed zones, Cr]]></keywords_en><summary_hr><![CDATA[Pitomi kesten (Castanea sativa Mill.) važana je, široko rasprostranjena, višestruko korisna vrsta drveća u mediteranskom području, od koje se koriste drvo, plodovi, med i tanin. Rak kestenove kore, uzrokovan introducirnom gljivom Cryphonectria parasitica, ugrožava opstanak sastojina pitomog kestena. Glavni cilj ovoga projekta je utvrditi: (1) neutralnu i adaptivnu raznolikost u prirodnim populacijama pitomog kestena u Hrvatskoj iz okolišno različitih staništa; (2) povezanost genetičke strukture, morfološke raznolikosti, kemijske raznolikosti i okolišnih razlika (klimatskih i pedoloških) u prirodnim populacijama i kultivarima pitomog kestena; (3) kvalitetu sjemena i zahtjeve za klijanje sjemena pitomog kestena; (4) genetičku osnovu raznolikosti za adaptivna svojstva na sadnicama uzgojenima u stakleniku i u recipročno-transpantacijskim pokusima; (5) epigenetičke odgovore na sušni stres; (6) tolerantnost selekcioniranih genotipova na patogene; (7) otpornost na patogene sadnica uzgojenih u rasadniku; (8) povezanost između populacijsko-genetičkog pristupa i pokusa u stakleniku kao i recipročno-transplantacijskih pokusa; (9) nastavak dugoročnog praćenja populacija C. parasitica; (10) neutralnu i adaptivnu raznolikost hrvatskih kultivara pitomog kestena; (11) razlike između hrvatskih kultivara pitomog kestena u morfologiji listova i plodova te kemijskom sastavu plodova; (12) razgraničenje sjemenskih zona i izrada smjernica za prijenos sjemena za hrvatske populacije pitomog kestena. Osim doprinosa osnovnim znanstvenim spoznajama o biologiji i ekološkim odnosima pitomog kestena, rezultati ovoga projekta doprinijet će održivom gospodarenju sastojinama pitomog kestena u Hrvatskoj. Rezultati će direktno doprinijeti zaštiti geografskog porijekla maruna, autohtonih hrvatskih kultivara pitomog kestena. Također će biti selekcionirani genotipovi tolerantni na sušni stres kao i oni s većom tolerancijom na biotski stres, odnosno infekciju gljivom Cryphonectria parasitica.]]></summary_hr><summary_en><![CDATA[The sweet chestnut (Castanea sativa Mill.) is a widely spread and important multipurpose tree species in the Mediterranean area, used for its wood, fruit, honey, and tannin. The chestnut blight, caused by the introduced fungus Cryphonectria parasitica, endangers the survival of the sweet chestnut stands. The main goal of this research is to reveal: (1) neutral and adaptive variability in sweet chestnut natural populations from different environmental habitats in Croatia; (2) associations between genetic structure, morphological variation, chemical variation and environmental differences (climatic and soil) in natural populations and in cultivars; (3) sweet chestnut seed quality and germination requirements; (4) genetic basis of variation for adaptive traits on seedlings reared in greenhouse and in reciprocal transplant experiments; (5) epigenetic responses to drought stress; (6) tolerance of selected genotypes to pathogens; (7) resistance to pathogens on seedlings reared in nursery; (8) associations between population genetic approach and greenhouse and reciprocal transplant experiments; (9) continuation of long term monitoring of C. parasitica populations; (10) neutral and adaptive variability in Croatian sweet chestnut cultivars; (11) differences in fruit and leaf morphology and chemical composition of fruits between Croatian marron cultivars; (12) delineation of seed zones and definition of seed transfer guidelines for Croatian sweet chestnut populations. Aside from contribution to the basic scientific knowledge on biology and ecological demands of sweet chestnut, the results will contribute to the sustainable management of sweet chestnut stands in Croatia. Results will contribute directly to the protection of geographic origin of the autochthonous marron cultivars. Croatian sweet chestnut genotypes tolerant to water stress and those with higher tolerance to biotic stress i.e. infection with C. parasitica, will be selected.]]></summary_en></project><project>
<id>7245</id><title_hr><![CDATA[Optimizacijski i statistički modeli i metode prepoznavanja svojstava skupova podataka izmjerenih s pogreškama]]></title_hr><title_en><![CDATA[]]></title_en><user_id>921</user_id><user_firstLast_name>Mirta Benšić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-6039</code><acronim><![CDATA[OSMoMeSIP]]></acronim><duration>01.07.2018 - 30.06.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Fakultet primijenjene matematike i informatike]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, School of Applied Mathematics and Informatics]]></institution_en><team_members_id>25217</team_members_id><team_members_names><![CDATA[ Doktorand: Una Radojičić ]]></team_members_names><keywords_hr><![CDATA[Optimizacija, Analiza velikih podataka, Grupiranje podataka, Dekonvolucija, Statistički modeli]]></keywords_hr><keywords_en><![CDATA[Optimization, Big data analysis, Data Clustering, Deconvolution, Statistical Models]]></keywords_en><summary_hr><![CDATA[U okviru projekta razmatraju se optimizacijski i statistički aspekti  prepoznavanja svojstava skupova podataka izmjerenih s pogreškama kao sastavni dio atraktivnog i aktivnog područja istraživanja poznatog kao analiza velikih podataka (engl. Big data analysis).  Istraživanja će biti usmjerena na  probleme grupiranja podataka te dekonvolucijske modele i primjene.  Polazi se od pretpostavke da  promatrani skupovi podataka  predstavljaju mjerene vrijednosti varijabli koje se analiziraju, ali u sebi sadrže grešku mjerenja. U velikim skupovima podataka vrlo često je prikladno podatke grupirati na temelju nekih karateristika te modelirati svaku grupu podataka posebnim modelima kojima se opisuju svojstva varijabli kao što su njihov  međusobni odnos, mogućnost separacije, rub skupa vrijednosti varijabli, oblik skupa vrijednosti varijabli, dimenzije (duljinu,  površinu ili volumen) skupa vrijednosti ili općenito vektor parametara kojim su te varijable određene. Problem se u mnogim konkretnim situacijama može formulirati u obliku optimizacijskog problema u kome kriterijska funkcija cilja općenito nije niti konveksna niti diferencijabilna.  U svrhu rješavanja takvih problema razvijat će se efikasne, brze i točne numeričke procedure. Također, zbog postojanja pogreške u podacima, u svrhu razumijevanja i pravilne interpretacije rezultata koristit će se statistički modeli te će se istražiti odgovarajuća statistička svojstva.  ]]></summary_hr><summary_en><![CDATA[As a part of an attractive and active area of research known as big data analysis, optimization and statistical aspects of recognizing data sets properties will be analyzed. Research will be focused on clustering problems, deconvolution models and applications. The assumption is that the observed data sets represent the measured values of the variables to be analyzed but also that they contain a measurement error. In large data sets it is often appropriate to cluster data sets on the basis of certain characteristics and then apply specific models for each group that can describe variable properties such as relationships among them, possibility of separation, edges, specific form of the set of values, dimensions (length, surface or volume) of the set of values or general parameter vector which determines them.  The problem in many practical situations can be formulated as an optimization problem for which the objective function is generally neither differentiable nor convex. In order to solve such problems effectively, rapid and accurate numerical procedures will be developed. Also, due to errors in the data, in order to understand and correctly interpret the results, statistical models will be used and important statistical properties will be characterized. ]]></summary_en></project><project>
<id>7251</id><title_hr><![CDATA[TransCultAA - Transfer of Cultural Objects in the Alpe Adria Region in the 20th century]]></title_hr><title_en><![CDATA[]]></title_en><user_id>402</user_id><user_firstLast_name>Ljerka Dulibić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-9585</code><acronim><![CDATA[]]></acronim><duration>01.09.2018 - 31.08.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Povijest umjetnosti, </scie_field_hr><scie_field_en>Art history, </scie_field_en><institution_hr><![CDATA[Hrvatska akademija znanosti i umjetnosti]]></institution_hr><institution_en><![CDATA[Croatian Academy of Sciences and Arts]]></institution_en><team_members_id>25208</team_members_id><team_members_names><![CDATA[ Doktorand: Bartol Fabijanić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>7256</id><title_hr><![CDATA[Disobedient Democracy: A Comparative Analysis of Contentious Politics in European Semi-periphery]]></title_hr><title_en><![CDATA[]]></title_en><user_id>7215</user_id><user_firstLast_name>Danijela Dolenec</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-4716</code><acronim><![CDATA[]]></acronim><duration>16.10.2018 - 31.12.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Politologija, </scie_field_hr><scie_field_en>Political Science, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet političkih znanosti]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Political Science]]></institution_en><team_members_id>25394</team_members_id><team_members_names><![CDATA[ Doktorand: Maja Gergorić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>7263</id><title_hr><![CDATA[ROBOCOM++  - Rethinking Robotics for the Robot Companion of the future]]></title_hr><title_en><![CDATA[]]></title_en><user_id>378</user_id><user_firstLast_name>Ivan Petrović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-9392</code><acronim><![CDATA[]]></acronim><duration>01.11.2018 - 30.08.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>22792</team_members_id><team_members_names><![CDATA[ Doktorand: Anđela Čirjak ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>7264</id><title_hr><![CDATA[Doprinos interne komunikacije uspješnosti organizacije: položaj, kanali,  mjerenje i odnos s povezanim konceptima]]></title_hr><title_en><![CDATA[The role of internal communication in an organization: position, channels, measurement and relationship with related concepts]]></title_en><user_id>23352</user_id><user_firstLast_name>Ana Tkalac Verčič</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-3323</code><acronim><![CDATA[IntComORG]]></acronim><duration>19.10.2018 - 18.10.2022</duration><status>Završio</status><financ_value>37.082,35 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Interdisciplinarne društvene znanosti, Ekonomija, Informacijske znanosti, Psihologija, </scie_field_hr><scie_field_en>Interdisciplinary social sciences, Economy, Information sciences, Psychology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Ekonomski fakultet u Zagrebu]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Economics and Business]]></institution_en><team_members_id>19833, 3974, 7317, 23842, 26347, </team_members_id><team_members_names><![CDATA[Dubravka Sinčić Ćorić, Zvonimir Galic, Nina Pološki Vokić, Dijana Najjar, Anja Špoljarić, ]]></team_members_names><keywords_hr><![CDATA[Interna komunikacija, Reputacija, Angažiranost, Marka poslodavca, Psihološki ugovor]]></keywords_hr><keywords_en><![CDATA[Internal communication, Reputation, Engagement, Employer brand, Psychological contract]]></keywords_en><summary_hr><![CDATA[Istraživanja pokazuju kako se svugdje u svijetu povjerenje zaposlenika u vodstvo organizacije smanjuje (Jiang i Probst, 2015; Coats, 2005; Tanner, 2011). Dodatne promjene koje pridonose većoj važnosti interne komunikacije uključuju smanjenja broja zaposlenika,  velike razlike u primanjima prosječnih zaposlenika i vodstva te masovne otkaze i njihov utjecaj na stupanj odanosti zaposlenika (Tkalac Verčič, 2016). Za internu komunikaciju u organizaciji to znači povećanu potrebu za iskrenom dvosmjernom komunikacijom. Globalizacija povećava usredotočenost na internu komunikaciju (Erkkila, 2010) kao i tehnologija koja je ubrzala povezivanje tržišta i organizacija (Mitić, Nikolić, Jankov, Vukonjanski i Terek, 2017). Osnovni cilj ovog projekta je proučavanje, definiranje i povezivanje pojedinih elemenata interne komunikacije s organizacijskom reputacijom putem medijatornih varijabli koje uključuju angažiranost zaposlenika, marku poslodavca, stupanj ispunjenosti psihološkog ugovora i percipiranu organizacijsku podršku. Povezivanje varijabli interne komunikacije s varijablama organizacijske uspješnosti najbolji je način mjerenja i time jasnijeg ustrojavanja funkcije interne komunikacije u organizaciji. Konačna svrha projekta je proširenje i prilagodba definicije interne komunikacije kako bi operacionalizacija precizno i realno odražavala stanje u organizacijskom okruženju; utvrđivanje položaja organizacijskog smještaja interne komunikacije te utvrđivanje mjera uspješnosti interne komunikacije koje se provode u hrvatskim organizacijama. Posebna pažnja biti će posvećena obilježjima internih javnosti, načinima segmentacije, društvenim medijima, angažiranosti zaposlenika, komunikaciji promjena, komunikaciji vodstva i načinima mjerenja i evaluacije. Istraživanje povezanosti zadovoljstva internom komunikacijom i razine angažiranosti zaposlenika značajno je za organizacijsku uspješnost baš kao i istraživanje potencijalne veze s markom poslodavca i reputacijom organizacije. ]]></summary_hr><summary_en><![CDATA[Research shows that all around the world employee trust in organizational leadership is declining (Jiang & Probst, 2015; Coats, 2005; Tanner, 2011). Additional changes that emphasize the significance of internal communication include huge differences in salaries between average employees and top management, mass employee reductions and the effect this has on the level of employee loyalty. For internal communication this means an increased need for open two-way communication. Globalization also increases focus on internal communication (Erkkila, 2010) as well as technology which brings markets and organizations even closer together (Mitić, Nikolić, Jankov, Vukonjanski & Terek, 2017). The main goal of this project is exploring, defining and connecting various elements of internal communication with organizational reputation through mediating variables which include employee engagement, employer brands, psychological contract fulfillment and perceived organizational support. Linking internal communication variables with indicators of organizational success is the best way to measure and establish internal communication as an organizational function. Connecting the level of internal communication satisfaction and the level of employee engagement is important for long term organizational success as is the potential connection with employer brands and organizational reputation.  The final goal of the project is to define internal communication in a way that will realistically and precisely reflect the situation in the organizational environment, to determine the typical position internal communication has in an organization and to define which measures of success are the best for internal communication in organizations. Special attention will be focused on characteristics of internal publics, typical segmentation techniques, social media choices, the level of employee engagement, change communication, leadership communication and measurement and evaluation techniques. ]]></summary_en></project><project>
<id>7268</id><title_hr><![CDATA[Elektroni, kaoni i neutroni u preciznim mjerenjima svojstava hadrona i jezgara]]></title_hr><title_en><![CDATA[Electrons, kaons and neutrons in high precision measurements of hadrons and nuclei properties]]></title_en><user_id>3809</user_id><user_firstLast_name>Damir Bosnar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-8570</code><acronim><![CDATA[EKNpEXP]]></acronim><duration>16.10.2018 - 15.03.2023</duration><status>Završio</status><financ_value>132.391,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>1479, 4413, 24068, 4993, 4909, 4395, </team_members_id><team_members_names><![CDATA[Mihael Makek, Petar Žugec, Darko Mekterović, Catalina Oana Curceanu, Ulrich Müller, Ivica Friščić, ]]></team_members_names><keywords_hr><![CDATA[Elektroni, kaoni, neutroni, hadroni, jezgre,mjerenja]]></keywords_hr><keywords_en><![CDATA[Electrons, kaons,neutrons, hadrons, nuclei, measurements]]></keywords_en><summary_hr><![CDATA[U fokusu su precizna mjerenja u eksperimentima elektronskih raspršenja na nukleonima i jezgrama na MAMI, spektroskopija X-zraka iz prijelaza u kaonskim atomima na DAPHNE i neutronske reakcije na jezgrama na n_TOF postrojenju na CERN-u. Važna komponenta je i razvoj i istraživanje detektora u laboratoriju u Zagrebu za buduće eksperimente.U eksperimentima elektronskih raspršenja elektromagnetski form faktori protona na niskom Q2 će biti određeni uporabom radijacije u početnom stanju kao doprinos pojašnjenju „zagonetke radijusa protona“, neslaganja protonskog radijusa određenog elektronskim i mionskim probama. Precizno određivanje protonskog magnetskog form faktora na višim Q2uporabom Rosenbluthove separacije će osigurati podatke za objašnjenje doprinosa izmjene dva fotona. Električni form faktor će biti mjeren u reakcijama prijenosa polarizacije novim neutronskim detektorom da se smanje sistematske nepouzdanosti. Istraživanja prirode nukleon-nukleon korelacija u jezgri bit će provedeno u eksperimentima s trostrukim koincidencijama. Kaon jezgre interakcije su od velike važnosti za nisko-energijsku QCD. Mjerenja X-zraka iz prijelaza u plinskim kaonskim atomima bit će napravljeno SIDDHARTA-2 detektorom na DAPHNE. Prijelazi u deuteriju su važni, zajedno s rezultatima za vodik, za određivanje isospinski ovisnih antikaon-nukleon duljina raspršenja,  a u heliju za pojašnjenje predloženih duboko vezanih kaonskih nuklearnih stanja. Prijelazi u određenim krutim metama bit će upotrijebljeni za studiju izvodivosti mjerenja mase nabijenog kaona s HPGe detektorom. Analiza podataka sakupljenih u određenim neutronskim reakcijama na n_TOF postrojenju od interesa u astrofizičkim i tehnološkim aplikacijama bit će završena uz znatnu uporabu procedura koje su razvili neki od sudionika projekta.Prototip sustava za detekciju gama zraka baziran na kinematici comptonskog raspršenja za određivanje smjera ulaznih gama zraka bit će sastavljen.    ]]></summary_hr><summary_en><![CDATA[In the focus are high precision measurements in electron scattering experiments on nucleons and nuclei at MAMI, spectroscopy of X-ray transitions in kaonic atoms at DAPHNE and neutron reactions on nuclei at n_TOF facility at CERN. Important component is also detector R&D in laboratory in Zagreb for future experiments.In electron scattering experiments the electromagnetic form factors of the proton at low Q2 using initial state radiation will be determined to contribute to the clarification of the “proton radius puzzle”, disagreement of the proton radius obtained using electron and muon probes. Precise determination of the proton magnetic form factor at higher Q2 by using Rosenbluth separation will provide data for the clarification of two-photon exchange contributions. The neutron electric form factor will be measured in polarization transfer reactions with the new neutron detector to reduce systematic uncertainties. The investigations of the nature of nucleon-nucleon correlations in nuclei will be done in triple coincidence experiments.Kaon-nucleons interactions are of big importance for low-energy QCD. Measurements of X-ray transitions in gaseous kaonic atoms will be done with the SIDDHARTA-2 detector at DAPHNE. Transitions in deuterium are important, with the hydrogen results, for determination of isospin dependent antikaon-nucleon scattering lengths and in helium for the proposed deeply bound kaonic nuclear states. Transitions in selected solid targets will be used for the feasibility study of the measurement of the charged kaon mass with a HPGe detector.Analysis of the data collected in specific neutron reactions on nuclei at n_TOF facility of interest for astrophysics and technological applications will be completed with the strong usage of the procedures developed by some of the project participants.A prototype of gamma detection system based on the kinematics of Compton scattering for the determination of incoming directions of gamma rays will be assembled.]]></summary_en></project><project>
<id>7272</id><title_hr><![CDATA[Mehanizmi nastajanja kalcijevih fosfata na anorganskim nanomaterijalima. Biomimetski put priprave multifunkcionalnih kompozita za regeneraciju čvrstih tkiva]]></title_hr><title_en><![CDATA[Mechanisms of calcium phosphates formation on inorganic nanomaterials. A biomimetic synthetic route for multifunctional nanocomposites for hard tissue regeneration]]></title_en><user_id>224</user_id><user_firstLast_name>Maja Dutour Sikirić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-1493</code><acronim><![CDATA[CaPBiomimNanocomp]]></acronim><duration>15.11.2018 - 14.03.2023</duration><status>Završio</status><financ_value>131.966,29 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, Interdisciplinarne prirodne znanosti, </scie_field_hr><scie_field_en>Chemistry, Interdisciplinary natural sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>1069, 339, 423, 4209, 404, 336, 19620, 19592, 28891, 865265, </team_members_id><team_members_names><![CDATA[Atiđa Selmani, Darija Domazet Jurašin, Suzana Šegota, Nadica Maltar Strmečki, Vida Čadež, Tea Mihelj Josipović, Barbara Vuković, Marija Milić, Ina Erceg, Suzana Inkret, ]]></team_members_names><keywords_hr><![CDATA[kalcijevi fosfati, anorganski nanomaterijali, bioaktivne molekule, kompoziti, biomimetski biomaterijali]]></keywords_hr><keywords_en><![CDATA[calcium phosphates, inorganic nanomaterials, bioactive molecules, composites, biomimetic biomaterials]]></keywords_en><summary_hr><![CDATA[Moderni način života i sve dulji životni vijek stanovništva rezultira sve većom učestalošću bolesti čvrstih tkiva (kostiju i zuba). Često je jedini način liječenja takvih oboljenja ugradnja implantata s ciljem regeneracije oboljelog ili oštećenog tkiva. Kako bi se izbjegli problemi vezani uz kvalitetu implantata, intenziviran je razvoj i istraživanje novih, inovativnih implant materijala. Pri tome se posebna pažnja pridaje kompozitnim multifunkcionalnim materijalima, koji osim poboljšanih osteoinduktivnih i mehaničkih svojstava, mogu djelovati i kao lokalni terapijski sustavi za isporuku lijekova. Kako bi takvi materijali bili što funkcinoalniji te kako bi se što više racionalizirao njihov dizajn potrebno je poznavati međudjelovanja komponenti kompozita. To vrlo često nije slučaj pa je pristup dizajnu i sintezi takvih materijala uglavnom empirijski.U posljednje vrijeme kompoziti kalcijevih fosfata (CaP) i anorganskih nanomaterijala (NM) privlače pažnju kao novi, široko primjenjivi materijali za regeneraciju čvrstih tkiva. Cilj predloženog projekta je sustavno istražiti međudjelovanja CaP i dvije vrste nanomaterijala NM, i) NM titanijevog dioksida različite morfologije (nanočestice, nanocjevčice, nanožice, nanopločice) i ii) srebrnih nanočestica različitih površinskih modifikacija, kako bi se utvrdio odnos između površinskih svojstava NM (površinske modifikacije, morfologije, gustoće površinskog naboja, kristalne strukture) i svojstava nastalih CaP u uvjetima bliskim fiziološkim. Također, istražit će se utjecaj albumina i hitosana na nastajanje CaP/NM kompozita, te odrediti potencijal njihove primjene kao materijala za regeneraciju čvrstih tkiva testovima imunokompatibilnosti i hemokompatibilnosti.Predloženi projekt doprinijeti će boljem razumijevanju procesa taloženja na nanopovršinama, što će omogućiti racionalniji pristup ne samo u biomimetskoj sintezi novih biokompozita za regeneraciju čvrstih tkiva, već i u sintezi kompozitnih materijala široke primjene.]]></summary_hr><summary_en><![CDATA[Population ageing and modern lifestyle leads to the increased frequency and consequently growing importance of hard tissues (bone and teeth) diseases. Often the only treatment of such diseases is implantation with the aim to regenerate affected tissue. To prevent failures of the hard tissue implants, new and innovative multifunctional implant materials are sought which, in addition to improved osteoinductive and mechanical properties, will act as local drug delivery system. In this sense, composite materials seems to be materials of choice. In order for these materials to be fully functional and to rationalize their design, the interactions between components should be fully understood. This very often is not the case and success stories are commonly result of empirical not systematic approach. New hard tissue regeneration biomaterials emerging in recent years are composite materials based on calcium phosphates (CaPs) and different inorganic nanomaterials (NMs). The aim of the proposed project is to systematically investigate the CaPs interactions with two types of inorganic NMs; i) titanium dioxide NMs of different morphology (nanoparticles, nanotubes, nanowires, nanoplates) and ii) silver nanoparticles of different surface modifications, in order to determine relationship between NMs interface properties (surface modification, morphology, surface charge density, crystal structure) and the properties of forming CaPs solid phase at conditions close to physiological. In addition, the influence of albumin and chitosan on the formation of CaP/NMs composites will be investigated and potential for their application will be determined using immunocompatibility and hemocompatibility tests. The proposed research will enable a deeper insight into precipitation processes on nanosurfaces, which will provide a rational approach not only in biomimetic synthesis of novel biocomposites for hard tissue regeneration but also in synthesis of materials for different applications.]]></summary_en></project><project>
<id>7274</id><title_hr><![CDATA[Nano-katalizatori aktivirani Sunčevim zračenjem u tehnologijama zaštite okoliša]]></title_hr><title_en><![CDATA[Nano-sized Solar-active Catalysts for Environmental Technologies]]></title_en><user_id>984</user_id><user_firstLast_name>Hrvoje Kušić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-1982</code><acronim><![CDATA[NaSCEnT]]></acronim><duration>22.10.2018 - 21.10.2022</duration><status>Završio</status><financ_value>136.392,84 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Kemijsko inženjerstvo, </scie_field_hr><scie_field_en>Chemical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet kemijskog inženjerstva i tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Chemical Engineering and Technology]]></institution_en><team_members_id>1122, 3651, 17765, 3845, 3168, 3191, 23523, 25653, 856133, 25650, 25242, 28791, </team_members_id><team_members_names><![CDATA[Ana Lončarić Božić, Marijana Kraljić Roković, Marin Kovačić, Urska Lavrencic Stangar, Panaghiotis Karamanis, Dionysios Dionysiou, Fernando Fresno, Klara Perović, Gabrijela Radić, Josipa Papac, Antonija Tomić, Tayebeh Sharifi, ]]></team_members_names><keywords_hr><![CDATA[solarna fotokataliza, nanokompozitni katalizatori, prioritetna onečišćivala, pročišćavanje vode, proizvodnja vodika]]></keywords_hr><keywords_en><![CDATA[solar photocatalysis, nanocomposite catalysts, priority substances, water purification, hydrogen production]]></keywords_en><summary_hr><![CDATA[Pristup pitkoj vodi i izvorima čiste energije neophodni su za ekonomski razvitak i napredak društva. Međuzavisnost proizvodnje energije i čiste vode dobro je poznata, međutim tehnologije trenutno nisu adekvatno integrirane. Inovativna ideja na kojoj počiva NaSCEnT projekt je dobivanje energije tijekom pročišćavanja vode. Takva hipoteza je utemeljena na istovjetnosti mehanizama koji se odvijaju tijekom fotokatalitičkog pročišćavanja vode te fotoelektrokemijskog cijepanja vode u svrhu dobivanja energije, to jest proizvodnju vodika (H2). Naime, oba procesa se temelje na istom osnovnom mehanizmu koji uključuje generiranje parova elektron/šupljina (e-/h+) na površini poluvodiča uslijed ekscitacije svjetlom, odnosno fotonima odgovarajuće energije. Glavni cilj NaSCEnT projekta je razvoj novog katalitičkog materijala nano-dimenzija (NKM), specifično razvijenog za učinkovito iskorištavanje Sunčeve energije u svrhu pročišćavanja vode i proizvodnje vodika. Sukladno tome, NKM će se pripremiti povezivanjem nanokompozitnih materijala sa poluvodičkim svojstvima na bazi TiO2, uz uključivanje SnS2, BiVO4, i ?-Fe2O3, te grafen oksida različitog stupnja redukcije (GO/rGO). Ciljana onečišćivala na kojima će se primijeniti solar/NKM sustav su farmaceutici, čiji su nusprodukti fotokatalitičke razgradnje niskomolekulske organske tvari koje mogu zamijeniti niskomolekulske alkohole koji se trenutno koriste u procesima fotoelektrokemijskog cijepanja vode. Optimiranje i procjena učinkovitosti solar/NKM sustava, uključujući okolišne, energetske i ekonomske aspekte, biti će provedena integriranjem računalnog i eksperimentalnog pristupa. Učinkovitost NKM-a će biti specifično podešavana kroz planirani dizajn i procedure sinteza, dok će se ugađanje ciljanih svojstava provesti pomoću modeliranja na molekularnoj razini. Rezultati NaSCEnT projekta imat će utjecaj na područja obrade vode i proizvodnje energije, te će utrti put ka primjeni nove, čiste i održive tehnologije.]]></summary_hr><summary_en><![CDATA[Accessible energy resources and clean water are nowadays among the highest priorities sustaining economic growth and societal wellbeing. Although the interdependency of energy and water is well known, the related technologies are still not sufficiently integrated. The groundbreaking idea of NaSCEnT project is to produce the clean energy while cleaning the water thus creating the shift of water-energy nexus paradigm. The underlying mechanism of photocatalytic processes for water purification and photoelectrochemical processes for energy conversion is basically the same. Both H2 production by water splitting and photocatalytic degradation of organic pollutants in water rely on the formation of electron/hole (e-/h+) pairs at a semiconducting material upon its excitation by the light with sufficient photon energy. The main goal of NaSCEnT is to develop novel nano-sized catalyst material (NCM) tailored to effectively harvest solar irradiation for simultaneous solar driven water purification and H2 production. Accordingly, NCM will be prepared by coupling semiconducting composites, made of TiO2 and semiconducting materials (SnS2, BiVO4, and ?-Fe2O3), and graphene oxide and its reduced form (GO/RGO). The NaSCEnT targets treatment of water polluted by pharmaceuticals. Their byproducts, low C-atom species, may mimic the role of lower C-atom alcohols, commonly used in H2 production in sole water splitting. The optimization and evaluation of solar/NCM system effectiveness, comprehending ecological, energetic and economic aspects will be performed integrating modeling and experimental approaches. The performance of NCM will be tailored through the planed design and development procedures. Fine tuning of the particular properties will be assisted by modeling at the molecular scale, thus minimizing the risk of the failure. The NaSCEnT results will address both water and energy fields and pave the way toward the application of innovative, clean and sustainable technologies.]]></summary_en></project><project>
<id>7275</id><title_hr><![CDATA[Utjecaj otvorenih požara na kvalitetu tla i voda]]></title_hr><title_en><![CDATA[Influence of Summer Fire on Soil and Water Quality]]></title_en><user_id>7706</user_id><user_firstLast_name>Ivica Kisić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-1645</code><acronim><![CDATA[POP&KTV]]></acronim><duration>01.12.2018 - 30.11.2022</duration><status>Završio</status><financ_value>121.020,64 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, Interdisciplinarne biotehničke znanosti, </scie_field_hr><scie_field_en>Agriculture, Interdisciplinary biotechnical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Agronomski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Agriculture]]></institution_en><team_members_id>20011, 23536, 19029, 23452, 19879, 19866, 5696, 19016, 19017, 4340, 26199, 28940, 865004, </team_members_id><team_members_names><![CDATA[Igor Bogunović, Marija Ćaćić, Darija Bilandžija, Goran Volf, Nevenka Ožanić, Barbara Karleuša, Željka Zgorelec, Ivana Vitasović Kosić, Aleksandra Perčin, Mak Kišević, Domina Delač, Bojana Horvat, Paulo Pereira, ]]></team_members_names><keywords_hr><![CDATA[erozija tla vodom, degradacija tla,erozija tla vodom, degradacija tla, bioraznolikost, s bioraznolikost, staklenički plinovi, mjere ublažavanja požara]]></keywords_hr><keywords_en><![CDATA[water erosion, soil degradation, water pollution, biodiversity, greenhouse gases, mitigation of summer fire]]></keywords_en><summary_hr><![CDATA[Požari otvorenoga prostora predstavljaju prirodnu katastrofu za cijeli prostor Republike Hrvatske, a osobito za Mediteranski dio RH. Dosadašnja iskustva pokazala su da je većina požara otvorenoga prostora inicirana paljenjem vatre na napuštenom poljoprivrednom zemljištu (Obad, 1990; Defilippis, 1997; Nodilo, 2003; Mamut, 2011; Matas, 2015). U posljednjih četrdesetak godina zabilježen je izraziti porast otvorenih požara. U razdoblju od 2006. do 2015. godine u prosjeku je u RH bilo godišnje 2541 otvoreni požar, a tijekom 2017. godine do kraja listopada zabilježen je najveći broj otvorenih požara – 4248. Jedna od najvećih posljedica otvorenih požara je povećanje erozijskih procesa što uzrokuje smanjenje kvalitete tla, onečišćenje voda, povećanje emisije stakleničkih plinova te smanjenje bioraznolikosti. Utjecaj požara na okoliš bi se u okviru ovoga projekta istraživao na nekoliko lokacija u Zadarskoj i Šibensko kninskoj županiji, ovisno o veličini i lokaciji požara. Požar bi morao biti u blizini otvorena vodotoka (rijeka Krka) ili jezera (Vransko jezero). Cilj istraživanja je kvantificirati posljedice po okoliš istraživanih požara; koliko požari uzrokuju degradaciju tla i onečišćenje voda, koliko povećavaju emisiju stakleničkih plinova, te kako utječu na obnovu vegetacije.Istraživanje bi uključivalo prikaz promjena meteoroloških pojava na prostoru Zadra i Šibenika tijekom zadnjih pedeset godina, te bi se temeljem podataka iz Statističkih ljetopisa i drugih raspoloživih baza, navele postotne promjene u načinu korištenja poljoprivrednih i šumskih površina. Bit će navedene postotne promjene u odnosu urbane i ruralne populacije. Izradila bi se karta erodibilnosti tla za istraživano područje. Opisale bi se posljedice požara na okoliš – utjecaj na izgled krajolika, tlo, vode, bioraznolikost i emisiju stakleničkih plinova. Mjerilo bi se površinsko otjecanje uzrokovano različitim intenzitetom kiše.]]></summary_hr><summary_en><![CDATA[Summer fire represent a natural disaster for the entire territory of the Republic of Croatia, and especially for the Mediterranean part of the Republic of Croatia. Previous experience has shown that most of the summer fire is initiated by burning fire on abandoned agricultural land (Obad, 1990; Defilippis, 1997; Nodilo, 2003; Mamut, 2011; Matas, 2015). Over the last forty years there has been a marked increase in summer fire. In the period from 2006 to 2015, there was an average of  2541 summer fire in Croatia, and during the year 2017, by the end of October, the largest number of summer fire was recorded - 4248. One of the greatest consequences of summer fire is increasing erosion processes thus reducing soil quality, water pollution, increasing greenhouse gas emissions  and biodiversity reduction. The impact of fire on the environment would be within the framework of this project explored at several locations in Zadar and Sibenik-Knin County, depending on the size and location of fire. The fire would have to be near an open watercourse (river Krka) or a lake (lake Vransko). The aim of the study is to quantify the environmental effects of the investigated fires; how  fires cause soil degradation and water pollution, how much they increase greenhouse gas emissions and how they affect the renewal of vegetation. The research would include an overview of the meteorological phenomena occurring in the Zadar and Šibenik areas over the past fifty years, and based on the data from the Statistical Yearbook and other available bases, the percentage changes in the use of agricultural and forest areas would be stated.  A percentage change in relation to the urban and rural population will be listed. A map of soil erodibility for the studied area will be created.  The effects of  fire on the environment will be described - its impact on landscape, soil, water, biodiversity and greenhouse gas emissions. The surface runoff would be measured by different rain intensity. ]]></summary_en></project><project>
<id>7276</id><title_hr><![CDATA[DNA kao dokaz o distribuciji i vitalnosti ugrožene balkanske divokoze]]></title_hr><title_en><![CDATA[]]></title_en><user_id>2954</user_id><user_firstLast_name>Nikica Šprem</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-4193</code><acronim><![CDATA[BalkCham]]></acronim><duration>02.07.2018 - 01.10.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Agronomski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Agriculture]]></institution_en><team_members_id>25111</team_members_id><team_members_names><![CDATA[ Doktorand: Sunčica Stipoljev ]]></team_members_names><keywords_hr><![CDATA[R. rupicapra balcanica, SNP, MHC, efektivna veličina populacije, inbreeding, populacijska struktura, Dinarske planine]]></keywords_hr><keywords_en><![CDATA[R. rupicapra balcanica, SNP, MHC, effective population size,  inbreeding, population structure,Dinaric mountains]]></keywords_en><summary_hr><![CDATA[Model vrsta projektnog prijedloga je balkanska divokoza (R. rupicapra balcanica), populacija sjeverozapadnih Dinarida u Hrvatskoj. Kao karizmatični papkar, balkanska divokoza, vodeća je vrsta kod očuvanja planinskog ekosustava Balkanskog poluotoka koji je jedan od 35 svjetski važnih lokaliteta biološke raznolikosti. Zbog mala veličina populacije i niska genetska varijabilnost populacija divokoza u Dinaridima podložna je mnogim čimbenicima. Sa svim dosadašnjim spoznajama, glavni cilj našeg projekta je analizirati genetsku strukturu balkanske divokoze, koristeći neutralni (SNP) biljeg i biljeg pod selekcijom (MHC kompleks) za procjenu statusa zaštite i proučiti mehanizme molekularne adaptaciji lokalne populacije. Nadalje, ekstrakcija DNA iz lubanja divokoza odstrjeljenih prije reintrodukcije i usporedba uspješnih sekvenci sa današnjim iz genske banke, te potencijalno rekonstruirati filogeografiju divokoza s Velebita. Okolišna i staništa analiza u GIS-u  provest će se analizom prisutnosti i godišnje migracije životinja. Sve to će se postići interdisciplinarnim istraživačkim timom sastavljenim od agronoma, biologa, šumara i veterinara. Rezultati našeg projekta će pružiti uvid u distribuciju i vitalnost, što je važno u uspostavljanju učinkovitog upravljanja buduće populacije divokoza u Dinaridima. Isto tako moramo biti svjesni da je biološka raznolikost kulturna baština stoga nam je dužnost zaštititi balkansku divokozu za buduće generacije.]]></summary_hr><summary_en><![CDATA[The model species of the project proposal is Balkan chamois (R. rupicapra balcanica), specifically population of the northwestern Dinaric Mountains in Croatia. As a charismatic ungulate, Balkan chamois, is an excellent flagship species for the conservation of the montane ecosystems of the Balkan Peninsula which is one of the world’s 35 biodiversity hotspots. The small population size and low genetic variability of the chamois populations in the Dinaric Mountains make them vulnerable to many factors. With all previous findings considered, main goal of our project is to analyse genetic structure of Balkan chamois, using neutral (SNP) and loci under selection (MHC complex) to estimate conservation status and to study mechanisms of molecular adaptation of local populations. Furthermore, DNA extraction from hunted chamois before reintroduction and comparison of successful sequences with contemporary ones from Gen bank, and potential reconstruction of phylogeography of chamois from Velebit Mountain. An environmental and habitat analyses in GIS will carry out to analysis of habitat occupation and annual migration of animals. This will be achieved by interdisciplinary research team composed of agronomist, biologists, forester and veterinarians. Results of our project will provide insights of distribution and vitality, what is important in establishment of the effective future management of chamois population in Dinaric Mountains. Also we must be aware that biodiversity is a cultural heritage and it is important to protect Balkan chamois for future generations.]]></summary_en></project><project>
<id>7278</id><title_hr><![CDATA[Istraživanje složenih multiferoičnih materijala pripravljenih metodama otopinske kemije ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>11136</user_id><user_firstLast_name>Igor Đerđ</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-1534</code><acronim><![CDATA[SOLFERROMAT]]></acronim><duration>17.07.2018 - 16.07.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Odjel za kemiju]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Department of Chemistry]]></institution_en><team_members_id>25200</team_members_id><team_members_names><![CDATA[ Doktorand: Jelena Bijelić ]]></team_members_names><keywords_hr><![CDATA[Multiferoici, telurati, volframati, metaloorganske mreže, struktura]]></keywords_hr><keywords_en><![CDATA[Multiferroics, Tellurates, Tungstates, Metal-organic framework, Structure]]></keywords_en><summary_hr><![CDATA[Kako su i feromagnetizam i feroelektricitet ključni u mnogim aspektima moderne tehnologije, zahtjevi za materijalima koji pokazuju oba svojstva predstavljaju značajnu fundamentalnu i tehnološku važnost. Ipak, kad se u jednofaznom materijalu pojavljuje dva ili više fero-uređenja, njihovo međudjelovanje može proizvesti novi učinak koji se manifestira kao električna polarizacija uslijed primjene magnetskoga polja ili, obratno, magnetizacija uslijed primjene električnog polja.Glavni je cilj projekta SOLFERROMAT dizajniranje tri nova tipa funkcionalnih multiferoičnih spojeva: i) metaloorganskih spojeva perovskitne strukture ABX3 (A = amin-kation, B = prijelazni metal, X = organski ligand)ii) hibridne organsko-anorganske perovskitne strukture ABX4 (A = amin-kation, B = prijelazni metal, X = halogeni element) iiii) kompleksnih dvostrukih ili pojedinačnih perovskita tipa A2B(Te/W)O6 ili A3B2(Te/W)O9 (A = laki dvovalentni metal, B = prijelazni metal).Principi moderne koordinacijske kemije koji uključuju sol-gel postupak, mehanokemiju i mehanokemiju potpomognutu otapalom bit će korišteni za dizajniranje novih materijala za pohranu podataka, poglavito za  spintronske uređaje. Pažljivo organizirani slijed sinteza, karakterizacija i mjerenja magnetskih, električnih i magnetoelektričnih svojstava omogućit će postizanje ovoga cilja.Predložena metodologija za karakterizaciju struktura i svojstava novih materijala jest sinergija tehnika korištenih u trima disciplinama: koordinacijskoj kemiji, fizici kondenzirane tvari i znanosti o materijalima.  Glavni je cilj projekta poboljšati istraživanje povezivanjem kristalnog inženjeringa s fizikom i kemijom materijala kako bi se otkrili materijali novih funkcionalnih multiferoičnih svojstava. ]]></summary_hr><summary_en><![CDATA[Since indeed both ferromagnetism and ferroelectricity are essential to many forms of modern technology the demand for materials displaying both properties is of a great fundamental and technological importance, however, when coexistence of two or more ferroic orders in single-phase material is found, and furthermore, intimately coupled, the coupling interaction could produce new effect which manifests itself as an appearance of an electric polarization upon applying a magnetic field, and the appearance of magnetization upon applying an electric field. The main objective of SOLFERROMAT proposal is the design of three novel types of functional multiferroic compounds: i) perovskite structured metal-organic frameworks ABX3 (A = amine cation, B = transition metal, X = organic ligand) ii) perovskite-like hybrid organic-inorganic structures ABX4 (A = amine cation, B= transition metal, X = halogen) and iii) complex double or single perovskites A2B(Te/W)O6 or A3B2(Te/W)O9 (A = light divalent metal, B = transition metal). Building principles of modern coordination chemistry including sol-gel route, mechanochemistry and solvent assisted mechanochemistry will be actively used to explore the fundamental potential of designing new solids for data storage, particularly for spintronic devices. Carefully organized sequence of synthesis, characterization, and magnetic, electric and magnetoelectric properties measurements will allow achieving this goal.The proposed methodology to characterize structure and properties of new materials is the synergy of techniques used in three disciplines: coordination chemistry, condensed matter physics and materials science. The main aim of the project is to enlarge research by introducing crystal engineering into the physics and chemistry of solids, in order to reveal materials with new functional multiferroic properties.]]></summary_en></project><project>
<id>7280</id><title_hr><![CDATA[Kooperativna robotika u nadzoru i istraživanju mora]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5962</user_id><user_firstLast_name>Nikola Mišković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-5239</code><acronim><![CDATA[CroMarX]]></acronim><duration>01.11.2018 - 30.06.2021</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>19973</team_members_id><team_members_names><![CDATA[ Doktorand: Ivan Lončar ]]></team_members_names><keywords_hr><![CDATA[robotika, kooperativna robotika, pomorska robotika, autonomna površinska plovila, autonomna ronilica, višerobotski sustavi]]></keywords_hr><keywords_en><![CDATA[robotics, cooperative robotics, marine robotics, autonomous surface marine vehicles, autonomous underwater vehicle, multi-robot systems]]></keywords_en><summary_hr><![CDATA[Bespilotna plovila (površinska i podvodna) se uspješno koriste za nadzor i istraživanje mora. Ona igraju veliku ulogu u mnogim područjima primjena kao što su morska biologija, morska ekologija, podvodna arheologija, akvakultura, pomorska sigurnost, offshore industrija. Sve pomorske zemlje, kao i Hrvatska koja ima jurisdikciju nad skoro polovicom Jadranskog mora, imaju obavezu nadgledati, istraživati i štititi svoja morska dobra.CroMarX projekt unosi novu dimenziju u nadzor i istraživanje mora uvođenjem kooperativnih plovila koja povećavaju operativnu učinkovitost. Glavni cilj CroMarX projekta je istražiti i razviti kooperativne upravljačke algoritme  u području pomorske robotike, uzimajući u obzir bespilotna površinska plovila (USV, engl. Unmanned Surface marine Vehicles) i bespilotne ronilice (UUV, engl. Unmanned Underwater Vehicles) u svrhu nadzora i istraživanja mora. Prvo, razvit ćemo kooperativne strategije za upravljanje flotom USV-ova kako bi se povećale sposobnosti distribuiranog nadzora mora. Drugo, razvit ćemo upravljačke algoritme koji omogućuju kooperaciju između USV-a i UUV-a, što će značajno povećati istraživačke sposobnosti UUV-ova kroz unaprjeđenje navigacijskih mogućnosti. Treće, razvit ćemo sustav za upravljanje misijama koji će osigurati pregled stanja plovila i imati ulogu korisniku prihvatljivog centra za upravljanje i zadavanje misija pojedinačnom plovilu kao i floti plovila. Na kraju, razvijeni algoritmi će biti eksperimentalno potvrđeni u sklopu tri definirana scenarija: 1) kooperativno upravljanje flotom USV-ova, 2) upravljanje flotom USV-ova koje se adaptira utjecajima iz okoliša, i 3) kooperativno upravljanje između USV-a i UUV-a.]]></summary_hr><summary_en><![CDATA[Unmanned marine vehicles (surface and underwater) are successfully exploited for monitoring and exploring the marine environment. They play a large role in many application fields such as marine biology, marine ecology, underwater archaeology, aquaculture, marine security, offshore industry. All maritime countries, as well as Croatia with jurisdiction over almost half of the Adriatic Sea, have the obligation to monitor, explore and protect their marine environment.CroMarX project brings a new dimension to marine monitoring and exploration by introducing cooperative marine vehicles that increase operational efficiency. The main objective of the CroMarX project is to investigate and develop cooperative control algorithms in the area of marine robotics, taking into account both unmanned surface marine vehicles (USVs) and an unmanned underwater vehicle (UUV) for the purpose of marine monitoring and exploration. Firstly, we will develop cooperative control strategies for operating a fleet of USVs in order to increase capabilities of distributed marine monitoring operations. Secondly, we will develop control algorithms that allow cooperation between a USV and a UUV, which will significantly enhance exploratory abilities of UUVs by increasing their navigational capabilities. Thirdly, we will develop a mission controller that will ensure situational awareness and act as a user-friendly command and control centre for commanding missions to individual vehicles as well as fleets of vehicles. Finally, the developed algorithms will be experimentally validated within three defined scenarios: 1) cooperative control of a fleet of USVs, 2) environmentally adaptive control of a fleet of USVs, and 3) cooperative control between a USV and a UUV. ]]></summary_en></project><project>
<id>7283</id><title_hr><![CDATA[Cas3 kao kontrolna točka obrane CRISPR-Cas: razjašnjenje  njegove regulacije istraživanjem stabilnosti proteina i prepisivanja u bakteriji Escherichia coli]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4503</user_id><user_firstLast_name>Ivana Ivančić Baće</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-8484</code><acronim><![CDATA[Cas3 status]]></acronim><duration>10.10.2018 - 31.12.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>25303</team_members_id><team_members_names><![CDATA[ Doktorand: Damjan Mitić ]]></team_members_names><keywords_hr><![CDATA[CRISPR-Cas, Cas3, E. coli, RecBCD, HNS]]></keywords_hr><keywords_en><![CDATA[CRISPR-Cas, Cas3, E. coli, RecBCD, HNS]]></keywords_en><summary_hr><![CDATA[Clustered regularly interspaced short palindromic repeats (CRISPR) i CRISPR-associated (Cas) proteini sačinjavaju adaptivni imunološki sustav bakterija i arheja u borbi protiv virusa i plazmida. Ovaj sustav temelji se na ugradnji kratkih fragmenata strane DNA (razmaknice) u regiju CRISPR procesom koji se zove adaptacija. Ugrađene razmaknice služe za pamćenje prethodnih infekcija. U bakteriji Escherichia coli poznata su dva načina adaptacije: naivna i pripremljena. Tijekom naivne adaptacije razmaknice se direktno uzimaju iz strane DNA, dok je u pripremljenoj adaptaciji neophodna već postojeća razmaknica koja stimulira ugradnju novih razmaknica iz iste strane DNA. Za oba načina adaptacije neophodni su proteini Cas1 i Cas2, dok su za pripremljenu adaptaciju još potrebni interferencijski kompleks Cascade i protein Cas3. Unatoč značajnom napretku u otkriću molekularnih mehanizama obrane sustavom CRISPR-Cas, detalji nastanka dvolančanih fragmenata DNA potrebnih za oba načina adaptacije nisu dovoljno poznati, a također je nedovoljno istražena i regulacija CRISPR-Cas interferencije. Za RecBCD smo mi i drugi pokazali da je potreban za pripremu i ugradnju razmaknice u naivnoj adaptaciji, a nedavno smo pokazali da je protein Cas3 ograničavajući faktor CRISPR-Cas interferencije u ovisnosti o temperaturi inkubiranja. To upućuje na mogućnost da postoji još jedna razina regulacije sustava CRISPR-Cas u bakteriji E. coli koju bismo željeli istražiti. Da bismo doznali više o proteinu Cas3, razlozima njegove neobične aktivnosti i ulogama u CRISPR-Cas adaptivnoj imunosti, ciljevi ovog projekta su a) razjasniti je li protein Cas3 reguliran na razini transkripcije i post-translacijski. b) Istražiti uloge proteina Cas3 i komponenti enzima RecBCD u izgradnji CRISPR imunosti (adaptaciji). Također bismo željeli istražiti jesu li uloge ovih proteina međusobno usklađene i povezane s drugim staničnim procesima uključenim u održavanje stabilnosti genoma.]]></summary_hr><summary_en><![CDATA[Clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated (Cas) proteins constitutes an adaptive immune system in bacteria and archaea against viruses and plasmids. It is based on integration of short fragments of foreign DNA (spacers) into the CRISPR array in a process called adaptation that serves as a memory of prior infections. Two modes of adaptation have been reported in Escherichia coli type IE system: naive and primed. During the naive adaptation, the spacers are directly obtained from a foreign DNA source while in primed adaptation the pre-existing spacer is required to enable enhanced uptake of new spacers from the same foreign DNA. Both modes require Cas1 and Cas2 proteins, and primed adaptation additionally requires interference complex Cascade and Cas3 protein. Despite the significant progress on the molecular mechanisms of defence by the CRISPR-Cas systems, details about generation of DNA fragments needed for both modes of adaptation are not sufficiently known, or mechanisms of the regulation of the CRISPR-Cas interference. We and others have recently shown that RecBCD enzyme is involved in spacer preparation and integration for naive adaptation, and we have very recently shown that Cas3 is the limiting factor for CRISPR-Cas interference depending on the temperature of incubation. This suggests a possibility that additional level of regulation of the CRISPR-Cas interference exists in E. coli. To learn more about the Cas3 protein, explain its unusual activity and find out about its roles in CRISPR-Cas adaptive immunity, the aims of this project are a) to understand if Cas3 is regulated in E. coli transcriptionally and post-translationally. (b) Delineate the roles of RecB and RecBC components of RecBCD and Cas3 protein in building CRISPR immunity (adaptation). We would also like to understand if their roles are coordinated and linked to other host cell genome maintenance processes.]]></summary_en></project><project>
<id>7286</id><title_hr><![CDATA[Utjecaj uključivanja istraživačkih učeničkih pokusa u srednjoškolsku nastavu fizike na razvoj znanstvenog zaključivanja i konceptualnog razumijevanja ]]></title_hr><title_en><![CDATA[Effect of inclusion of students&#39; investigative experiments in secondary school physics teaching on the development of scientific reasoning and conceptual understanding]]></title_en><user_id>23490</user_id><user_firstLast_name>Maja Planinić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-9085</code><acronim><![CDATA[INVESTIGATE]]></acronim><duration>22.10.2018 - 21.06.2023</duration><status>Završio</status><financ_value>61.716,11 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Interdisciplinarne prirodne znanosti, Fizika, </scie_field_hr><scie_field_en>Interdisciplinary natural sciences, Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>23541, 23543, 23550, 23643, </team_members_id><team_members_names><![CDATA[Ana Sušac, Karolina Matejak, Lana Ivanjek, Katarina Jeličić, ]]></team_members_names><keywords_hr><![CDATA[nastava fizike, istraživanje, istraživački pokus, znanstveno zaključivanje, konceptualno razumijevanje, valna optika]]></keywords_hr><keywords_en><![CDATA[ physics teaching, inquiry, investigative experiment, scientific reasoning, conceptual understanding, wave optics]]></keywords_en><summary_hr><![CDATA[U Hrvatskoj se trenutno nastoji provesti reforma u nastavi fizike s ciljem promicanja istraživački usmjerene nastave fizike u srednjim školama. Novi bi pristup trebao uključiti mnogo više učeničkih istraživačkih pokusa nego li je sada slučaj. Stoga je važno istražiti učinak njihovog uključivanja, te procijeniti moguće dobrobiti, kao i probleme.  Istraživanje bi se fokusiralo na  valnu optiku, koja se poučava u četvrtom razredu srednje škole (u dobi od 18 – 19 godina).  Postojeća istraživanja već ukazuju na mnoge učeničke konceptualne poteškoće u ovom području i sugeriraju da je ovu temu teško dobro savladati bez pokusa. Nedostatak odgovarajuće eksperimentalne opreme u većini srednjih škola, kao i nedostatak nastavnika fizike s iskustvom u provođenju ovakve nastave,  predstavljaju dodatnu veliku prepreku za uvođenje istraživački usmjerene nastave u hrvatske srednje škole. Cilj bi ovoga projekta  stoga bio osigurati potrebnu opremu, trening i podršku za uključene nastavnike, te tada procijeniti učinak nastavne intervencije na znanstveno zaključivanje i konceptualno razumijevanje valne optike srednjoškolskih učenika. Učeničko znanstveno zaključivanje bilo bi procijenjeno Lawsonovim testom znanstvenog zaključivanja. Za procjenu učeničkog razumijevanja  valne optike bit će razvijen novi instrument (test).  Za razvijanje testa i mjerenje učeničkih sposobnosti i prirasta znanja koristit će se Raschovo modeliranje. Očekivani rezultati projekta uključuju novi dijagnostički test iz valne optike, srednjoškolske istraživački usmjerene nastavne materijale za valnu optiku,  pregled poteškoća hrvatskih učenika  vezanih uz tu temu, te ocjenu učinka istraživačkih pokusa iz valne optike na učeničko znanstveno zaključivanje i konceptualno razumijevanje. ]]></summary_hr><summary_en><![CDATA[The current reform efforts in Croatia in the field of physics teaching are aimed at promoting inquiry –based teaching in Croatian secondary schools. The new approach should include many more investigative students&#39; experiments than is currently the case. It is important to investigate the effects of their inclusion,  and to assess the possible benefits and problems.  The research would be focused on wave optics , which is taught in the fourth year of secondary school (age 18-19 years).  The existing research already points to many student conceptual difficulties, and suggests that this topic is hard to master without experiments. However, the lack of the adequate experimental equipment in most secondary schools,  as well as the lack of physics teachers experienced in this kind of teaching, presents a huge obstacle for the introduction of inquiry-based teaching in Croatian secondary schools.  The aim of this project would therefore be to provide the necessary equipment, training and support for participating teachers, and then to estimate the effect of the teaching intervention on the secondary school students&#39; scientific reasoning and conceptual understanding .  Students&#39; scientific reasoning would be estimated with Lawson&#39;s classroom test of scientific reasoning. For the estimation of students&#39; conceptual understanding of wave optics, a new instrument (test) will be developed.  Rasch modelling will be used for test development and measurement of student abilities and gains. The expected results of the project will include a new diagnostic test in wave optics, an overview of Croatian student difficulties regarding this topic, and an assessment of the effect of investigative experiments in wave optics on students&#39; scientific reasoning and conceptual understanding.  ]]></summary_en></project><project>
<id>7288</id><title_hr><![CDATA[Biološka važnost dipeptidil peptidaze III i njezin utjecaj na zdravlje čovjeka              ]]></title_hr><title_en><![CDATA[Biological relevance of dipeptidyl peptidase III and its impact on human health]]></title_en><user_id>2974</user_id><user_firstLast_name>Sanja Tomić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-2936</code><acronim><![CDATA[DPP3BioRe]]></acronim><duration>01.10.2018 - 30.09.2022</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, Fizika, Biologija, </scie_field_hr><scie_field_en>Chemistry, Physics, Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>2975, 1522, 17312, 4619, 2700, 730, 23593, 11070, 22463, 5071, 1186, 27544, </team_members_id><team_members_names><![CDATA[Antonija Tomić, Zrinka Karačić, Karl  Gruber, Mihaela Matovina, Dejan Agić, Ana Tomašić Paić, Filip Šupljika, Hrvoje Brkić, Sara Matić, Marija Abramić, Ivana Kekez, Antonia Matić, ]]></team_members_names><keywords_hr><![CDATA[metaloenzim, peptidaza, proteinske interakcije, parametri za ion cinka, vezno mjesto, inhibicija, neuropeptidi, DPP III, Keap1-Nrf2 signalni put]]></keywords_hr><keywords_en><![CDATA[metalloenzyme, peptidase, protein interaction, zinc ion parameters, binding site, inhibition, neuropeptides, DPP III, Keap1-Nrf2 signalling pathway]]></keywords_en><summary_hr><![CDATA[Poznato je da ljudska dipeptidil peptidaza III (hDPP III) in vitro katalizira hidrolizu nekih neuropeptida, te da je uključena u stanični odgovor na oksidativni stres preko Keap1-Nrf2 signalnog puta.Cilj predloženog istraživanja je proširiti znanje o biološkom značaju te cink-ovisne egzopeptidaze i njezinom utjecaju na zdravlje čovjeka. Kako bismo postigli zadani cilj, planiramo: (1) razviti nove parametre za ion cinka u proteinima i optimizirati računalne metode u istraživanju strukture metaloenzima, (2) pobliže razjasniti ulogu hDPP III u oksidativnom stresu proučavanjem njenog sudjelovanja u Keap1-Nrf2 signalnom putu, (3) proučiti vezanje nekoliko metalnih dikationa (Zn2+, Cu2+, Mn2+ i Co2+ ) za hDPP III, rasvjetliti mehanizam njihove izmjene i identificirati potencijano inhibitorno vezno mjesto metala, (4) unaprijediti saznanja o prirodnim supstratima ljudske DPP III, te (5) nastojati pronaći nove, moćne inhibitore katalitičke funkcije hDPP III.Novorazvijeni parametri bit će primjenjivi ne samo na hDPP III, već i na druge o cinku ovisne proteine sa sličnim veznim mjestom za metal. Kombinacija računalnog i eksperimentalnog (kinetičkog, spektrometrijskog, strukturalnog i termodinamičkog) pristupa donijet će nova saznanja o protein-protein (hDPP III – Keap1) i protein-ligand (hDPP III – peptidi/inhibitori) interakcijama na molekularnoj razini i njihovoj povezanosti s prijenosom signala u stanici. Ovo istraživanje trebalo bi ponuditi nove smjerove u razvoju farmakoloških spojeva s mogućnošću kontroliranja mehanizama u koje je DPP III uključena.]]></summary_hr><summary_en><![CDATA[It is known that human dipeptidyl peptidase III (hDPP III) cleaves several neuropeptides in vitro, and participates in the cellular oxidative stress response through the involvement in Keap1-Nrf2 signalling pathway. The aim of the proposed research is to advance the knowledge on biological relevance of this zinc dependent exopeptidase and its influence on human health. In order to achieve this, we plan to: (1)  develop new parameters for Zn2+ ion in proteins and optimize the computational approaches in the study of metalloenzyme structure, (2) come closer in understanding the role hDPP III has in the oxidative stress by studying its involvement in the Nrf2-Keap1 signalling pathway, (3) study the binding of several metal dications (Zn2+, Cu2+, Mn2+, and Co2+ ) to hDPP III and mechanism of their exchange, as well as to find the potential inhibitory metal binding site, (4) improve the knowledge on DPP III natural substrates in human, and (5)  search for new, potent inhibitors of the hDPP III catalytic function.The newly developed parameters will be beneficial not only for hDPP III but also for the other zinc dependent proteins with similar metal binding site. The combined computational and experimental (kinetic, spectrometric, structural and thermodynamic) approach should advance the knowledge of the molecular basis of protein-protein (hDPP III – Keap1) and protein-ligand (hDPP III – peptides/inhibitors) interactions and their implications on cell signalling. The study should suggest directions  for the development of pharmacological molecules with potential to control processes in which human DPP III participates.]]></summary_en></project><project>
<id>7289</id><title_hr><![CDATA[Istraživanje granice između neurodegeneracije i neuroregeneracije: identifikacija ključnih molekula pomoću proteomike i funkcionalnih testova na leđnoj moždini sisavaca]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5326</user_id><user_firstLast_name>Miranda Mladinić Pejatović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-3087</code><acronim><![CDATA[DefineREgenAgeMode]]></acronim><duration>23.07.2018 - 22.03.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Fakultet biotehnologije i razvoja lijekova]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Biotechnology and Drug Development]]></institution_en><team_members_id>19202</team_members_id><team_members_names><![CDATA[ Doktorand: Ivana Tomljanović ]]></team_members_names><keywords_hr><![CDATA[regeneracija sisavaca, Monodelphis domestica, oposum, embrionalni razvoj, središnji živčani sustav, leđna moždina, rast aksona, proteomika]]></keywords_hr><keywords_en><![CDATA[mammalian regeneration, Monodelphis domestica, opossum, embryonal development, central nervous system, spinal cord, axonal growth, proteomics]]></keywords_en><summary_hr><![CDATA[Jedan od glavnih izazova suvremene biologije je nemogućnost odraslog središnjeg živčanog sustava (SŽS) sisavaca da se regenerira i oporavi nakon ozljede. Za razliku od odraslih sisavaca, niži kralježnjaci, kao što su ribe i vodozemci, te viši kralježnjaci tijekom embrionalnog razvoja mogu obnoviti znatan dio svog SŽS. Vrlo je nejasno kako se i zašto regenerativni potencijal gubi tijekom evolucije i razvoja i zašto je vrlo ograničen u odraslih sisavaca. Povoljan model za istraživanje i otkrivanje osnove ovog gubitka je mladi oposum (Monodelphis domestica). Oposumi su tobolčari koji se rađaju vrlo nezreli i imaju jedinstvenu mogućnost uspješne regeneracije leđne moždine nakon ozljede u prva dva tjedna svog života, te stoga pružaju izuzetnu priliku za istraživanje neuronalne regeneracije. U svojim sam prethodnim istraživanima identificirala gene čiji se izražaj razlikuje u tkivu leđne moždine oposuma koji imaju ili nemaju sposobnost regeneracije. U ovom istraživanju želimo nadograditi prijašnji pristup analizom proteoma tkiva leđne moždine oposuma različite dobi, kako bi se otkrile molekule povezane s regenerativnim rastom aksona i proliferacijom matičnih stanica. Inhibicijom aktivnosti odabranih molekula ispitat će se njihova funkcionalna uloga u regeneraciji živčanog tkiva, koristeći in vitro preparate intaktne leđne moždine i napredno mikroskopiranje. Paralelno, pripremiti ćemo i analizirati primarne stanične kulture iz tkiva leđne moždine oposuma različite dobi, kako bi testirali odabrane molekule, s težištem na onima koje kontroliraju aktivnost matičnih stanica vezanu za regeneraciju. Ovo originalno interdisciplinarno temeljno istraživanje koristi jedinstveni životinjski model i ujedinjuje napredne tehnike biotehnologije te molekularne i stanične neurobiologije. Rezultati ovog projekta mogli bi dati značajan doprinos razumijevanju regeneracije živčanog tkiva sisavaca, ali i pružiti osnovu za buduće nove terapijske postupke vezane za neurodegenerativne poremećaje.]]></summary_hr><summary_en><![CDATA[One of the major challenges of modern biology concerns the inability of the adult mammalian central nervous system (CNS) to regenerate and repair itself after injury. Unlike the situation in adult mammals, lower vertebrates, such as fish and amphibians, and embryonal higher vertebrates can regenerate significant portions of their CNS. It is poorly understood why this potential is lost with evolution and development, and becomes very limited in adult mammals. An advantageous model to understand the basis of this loss is the neonatal opossum (Monodelphis domestica). Opossums are marsupials born immature, with the unique ability to successfully regenerate spinal cord after injury postnatally: this property, therefore, offers an exceptional tool to study neuro-regeneration. In my previous studies I have identified the genes differentially expressed in the regenerating and non-regenerating opossum spinal tissue. In the present application we wish to upgrade approach and to analyze the proteoms of the spinal tissue of the opossums at different ages, looking for molecules associated with regenerative axon growth and stem cell proliferation. The activity of candidate molecules will be inhibited to investigate their functional role in neuronal regeneration using the in vitro intact spinal cord preparation and advanced imaging. In parallel, we will prepare and analyze opossum primary spinal cell cultures made from the animals of different age, to test candidate proteins, with focus on those involved in stem/progenitor cell activity related to regeneration. This original interdisciplinary basic research project, unique in the choice of the animal model to be used, combines advanced techniques of biotechnology and molecular and cellular neurobiology. The results of the project would make substantial contribution to our understanding of neuronal regeneration in mammals, and also provide candidate targets for future novel therapeutic interventions for neurodegenerative disorders.]]></summary_en></project><project>
<id>7290</id><title_hr><![CDATA[Sustav vjetar-sunce za optimiziranu proizvodnju električne energije u rezidencijalnim objektima]]></title_hr><title_en><![CDATA[]]></title_en><user_id>11280</user_id><user_firstLast_name>Mateo Bašić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-9865</code><acronim><![CDATA[WINDSOR]]></acronim><duration>17.10.2018 - 01.01.2023</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Fakultet elektrotehnike, strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Electrical Engineering, Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>25306</team_members_id><team_members_names><![CDATA[ Doktorand: Matija Bubalo ]]></team_members_names><keywords_hr><![CDATA[Proizvodnja električne energije, Samouzbudni asinkroni generator, Fotonaponski sustav, Modeliranje, Umjetna inteligencija, Optimizacija]]></keywords_hr><keywords_en><![CDATA[Electric power generation, Self-excited induction generator, Photovoltaic system, Modelling, Artificial Intelligence, Optimization]]></keywords_en><summary_hr><![CDATA[Važna motivacija za izradu predloženog projekta je potreba gradskih područja za zelenom i povoljnom energijom. U okviru ovog istraživačkog projekta razvit će se sustav za optimiziranu proizvodnju električne energije koji kao izvore električne energije sadrži vjetroagregat sa samouzbudnim asinkronim generatorom (SEIG od engl. Self-Excited Induction Generator), fotonaponski sustav i baterije. Predloženi sustav će se istraživati u otočnom režimu rada kao i s priključkom na električnu mrežu.Specifični ciljevi projekta su sljedeći: (i) Razvoj naprednog modela SEIG-a i pripadajućeg sustava vektorske regulacije s vjetroturbinom i trofaznim PWM-upravljanim ispravljačem, koji će uključivati: optimizaciju korisnosti vjetroagregata primjenom neizrazite logike; detekciju brzine vrtnje SEIG-a bez upotrebe mjernog člana; regulaciju napona SEIG-a primjenom naprednog regulatora temeljenog na teoriji algebre granica i genetičkim algoritmima te optimizaciju PWM modulacije ispravljača. (ii) Razvoj izmjenjivača kvazi Z-tipa čiji ulaz čini istosmjerna sabirnica na koju su priključeni PWM-upravljani ispravljač, fotonaponski sustav i baterije, a izlaz se koristi za napajanje trofaznih izmjeničnih trošila ili za priključak na električnu mrežu. Za potrebe sinkronizacije ovog izmjenjivača s električnom mrežom razvit će se novi sustav fazno zatvorene petlje temeljen na teoriji algebre granica i genetičkim algoritmima.(iii) Razvoj simulacijskog modela fotonaponskog sustava koji će uključivati utjecaj osunčanosti fotonaponske ćelije na njenu temperaturu, kapacitet diode fotonaponske ćelije te korekciju uobičajenog izraza za struju zasićenja diode. Za potrebe optimizacije korisnosti fotonaponskog sustava razvit će se algoritam za praćenje točke maksimalne snage, spregnut s regulacijom ulaznog napona izmjenjivača kvazi Z-tipa.Planirano istraživanje će se provesti u suradnji sa znanstvenicima iz Instituta informatičke tehnologije u Hanoju i Fakulteta elektronike u Thai Nguyenu. ]]></summary_hr><summary_en><![CDATA[An important motivation for the proposed project is the need of urban areas for green and affordable energy.Under this research project, a wind-solar system for optimized electric generation will be developed, containing a wind energy conversion system (WECS) with a self-excited induction generator (SEIG), a photovoltaic (PV) system, and batteries as sources of electric power. The proposed system will be investigated in island mode and in grid-connected mode.The specific objectives of the project are as follows:(i) Development of an advanced SEIG model and a corresponding vector control system with a wind turbine and a three-phase PWM-controlled rectifier, which will include the following features: fuzzy-logic-based optimization of the WECS’s efficiency; sensorless detection of the SEIG’s speed; control of the SEIG’s voltage by means of an advanced controller based on the hedge algebra theory and genetic algorithms, and optimization of the rectifier PWM control.(ii) Development of a quasi-Z-source inverter (qZSI) whose input is connected to a DC bus to which the PWM-controlled rectifier, the PV system, and the batteries are also connected, whereas the output of the qZSI is used for supplying three-phase AC loads or for connection to the electric grid. For the purpose of synchronization of the qZSI with the electric grid, a new phase-locked loop will be developed based on the hedge algebra theory and genetic algorithms.(iii) Development of a simulation model of the PV system including the impact of the PV cell irradiance on its temperature, the capacitance of the PV cell diode, and correction of the common term for the diode saturation current. A maximum-power-point-tracking algorithm, coupled with the control of the qZSI’s input voltage, will be developed for optimization of the PV system’s efficiency.The planned research will be carried in collaboration with researchers from the Institute of Information Technology, Hanoi, and Faculty of Electronics, Thai Nguyen.]]></summary_en></project><project>
<id>7292</id><title_hr><![CDATA[Rogozničko morsko jezero kao model odziva ekosustava na promjene u okolišu]]></title_hr><title_en><![CDATA[MARine lake (Rogoznica) as a model for EcoSystem functioning in a changing environment]]></title_en><user_id>287</user_id><user_firstLast_name>Irena  Ciglenečki-Jušić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-1717</code><acronim><![CDATA[MARRES]]></acronim><duration>22.10.2018 - 21.10.2022</duration><status>Završio</status><financ_value>134.806,56 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Interdisciplinarne prirodne znanosti, Matematika, Fizika, Kemija, Biologija, </scie_field_hr><scie_field_en>Interdisciplinary natural sciences, Mathematics, Physics, Chemistry, Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>454, 3702, 1020, 3035, 290, 19245, 19525, 2977, 278, 17873, 1155, 19321, 4486, 23749, 25748, 856281, </team_members_id><team_members_names><![CDATA[Palma  Orlović-Leko, Tatjana Bakran-Petricioli, Mathieu Dutour Sikirić, Katja Magdić Košiček, Marija Marguš, Željko Grahek, Ivana  Tucaković, Iris Dupčić Radić, Milan Čanković, Ana  Cvitešić Kušan, Jelena Dautović, Ivana Coha, Donat Petricioli, Kristijan Vidovic, Sarah Mateša, Niki Simonović, ]]></team_members_names><keywords_hr><![CDATA[Rogozničko jezero,  specijacija i dinamika S spojeva,biogeokemijski procesi, unos iz atmosfere,  radionuklidi ]]></keywords_hr><keywords_en><![CDATA[Rogoznica lake, S speciation and dynamics, biogeochemical processes, atmospheric input, radionuclides]]></keywords_en><summary_hr><![CDATA[MARRES, nastavak SPHERE projekta, ima za cilj koristiti jedinstveni okoliš Rogozničkog jezera kao primjer  ugroženog morskog sustava koji odražava sve hidrografske i atmosferske uvjete Jadranskog mora. U okviru MARRES-a  Rogozničko jezero biti će model za praćenje i karakterizaciju biogeokemijskih procesa kruženja sumpora i ugljika na različitim redoks granicama faza, odnosno pri različitim okolišnim uvjetima. Znanstvenu misiju MARRES će postići suvremenim laboratorijskim tehnikama i radom na terenu, objedinjenim u jedinstveno biogeokemijsko istraživanje. Važan dio projekta biti će usmjeren na transport i izmjenu između atmosfere, vodenog stupca i sedimenta jezera, mjerenjem unosa sumpornih spojeva, organske tvari, radionuklida, nutrijenata i tragova metala mokrim taloženjem iz kiše. Ovisno o specifičnim fizičko-kemijskim uvjetima  pratiti će se i diskutirati ekologija mikroorganizama, fito- i zoo-planktona, te bentosa. Analiza i rasprava novih i dugoročnih podataka ekološkog  statusa jezera, osnovni je preduvjet za razvoj biogeokemijskog modela. Osim Rogozničkog jezera, drugi sustav za praćenje promjena u okolišu povezanih s eutrofikacijom, biti će sjeverni Jadran kao primjer poluzatvorenog, plitkog i potencijalno eutrofnog morskog bazena s povremenim pojavama pridnene anoksije. Istraživanja MARRESa planirana su na vremenskoj skali  od 4 godine, a dobiveni rezultati će značajno pridonijeti općem znanju o stanju i odgovorima istraživanih ekosustava na promjene fizikalnih, kemijskih i bioloških uvjeta uslijed prirodnih i antropogenih, odnosno globalnih promjena u okolišu. Gore navedeni istraživački ciljevi, posebice oni vezani za mobilizaciju ljudskih, tehničkih i infrastrukturnih kapaciteta IRB-a, kao i uključenih partnerskih institucija, usko su usklađeni sa strateškim prioritetima i promicanjem hrvatske znanosti, znanja i iskustva na svjetskom znanstvenom tržištu.]]></summary_hr><summary_en><![CDATA[MARRES, the continuation of the SPHERE project, aims to put in focus Rogoznica lake as an unique example of the threatened marine ecosystems, which feels hydrographic and atmospheric conditions of the Adriatic Sea. Rogoznica lake will be a model for monitoring and characterization of biogeochemical processes related to sulfur and carbon cycling at different redox boundaries under different environmental conditions. The project will achieve scientific mission by state-of-the art laboratory studies and field monitoring integrated in an unique biogeochemical research. Discussion and synthesis of new and long term data of the Lake’s ecological status is fundamental for development of biogeochemical model. An important part of the project will be focused on the exchange and transport between atmosphere, water column and sediment by measuring the atmospheric input (wet deposition) of sulfur compounds (organic and inorganic), organic carbon, radionuclides (Be-7, Pb-210), nutrients and trace metals. Additionally, the ecology of the microorganisms, phyto-  and zoo-plankton, bentos will be correlated with specific lake water physico-chemical conditions. The northern Adriatic as a semi closed, shallow and potentially eutrophic marine basin with occasional appearance of bottom anoxia will be used as another system for tracking environmental changes related to eutrophication. The MARRES is planned for the period of 4 years, and its result will contribute substantially to the improvement of the knowledge on the studied ecosystems responses to likely changes of physical, chemical and biological conditions affected by natural and anthropogenic i.e. global environmental change. Research objectives listed above, especially those related to mobilization of human, technical, and infrastructural capacities of the RBI and involved partner Institutions  are closely in line with strategic priorities and promotion of Croatian science, knowledge and experience on the world science market.]]></summary_en></project><project>
<id>7294</id><title_hr><![CDATA[Vitalitet obične bukve (Fagus sylvatica L.) u izmijenjenim klimatskim uvjetima]]></title_hr><title_en><![CDATA[Vitality of common beech (Fagus sylvatica L.) in changing climate conditions]]></title_en><user_id>848</user_id><user_firstLast_name>Nenad Potočić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-5222</code><acronim><![CDATA[VitaClim]]></acronim><duration>01.11.2018 - 31.10.2022</duration><status>Završio</status><financ_value>131.881,72 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Šumarstvo, Interdisciplinarne biotehničke znanosti, </scie_field_hr><scie_field_en>Forestry, Interdisciplinary biotechnical sciences, </scie_field_en><institution_hr><![CDATA[Hrvatski šumarski institut]]></institution_hr><institution_en><![CDATA[Croatian Forest Research Institute]]></institution_en><team_members_id>849, 23575, 13518, 19450, 19502, 19459, 19870, 19035, 23784, 1121, 861738, </team_members_id><team_members_names><![CDATA[Ivan Seletković, Mladen Ognjenović, Tomislav Levanič, Jonard Mathieu, Pasi Rautio, Volkmar Timmermann, Nicole Wellbrock, Miran Lanšćak, Karin Rebel, Renata Sokol Jurković, Mia Marušić, ]]></team_members_names><keywords_hr><![CDATA[defolijacija, prirast, ishrana bilja, fotosinteza, modeliranje, rasadnički pokus]]></keywords_hr><keywords_en><![CDATA[defoliation, increment, foliar nutrition, photosynthesis, modelling, nursery trial]]></keywords_en><summary_hr><![CDATA[Vitalitet ili stanje stabla možemo definirati kao sposobnost stabla da asimilira, preživi stres i reagira na promjenu okolišnih uvjeta. Promijenjeni klimatski uvjeti smatraju se kritičnim za stanje stabala, jer određuju dostupnost vode u smislu njezine apsorpcije i transporta u drveću, a nedostatak vode uzrokuje nedostatnu ishranu biljaka i posljedični gubitak vitaliteta. Osnovni cilj ovog projekta je istražiti utjecaj promijenjenih klimatskih uvjeta na različite indikatore vitaliteta drveća, kao i njihove moguće međuovisnosti.Koristit ćemo nacionalne i europske podatke o osutosti obične bukve iz baze podataka ICP Forests programa i upotpuniti ih uzorkovanjem lišća, tla i izvrtaka stabala bukve na ICP Forests plohama razine I u Hrvatskoj. Povijesni klimatski podaci i projekcije klime biti će korišteni za daljnje analize. Modelirati ćemo promjene osutosti kroz vrijeme i prostor i odrediti utjecaj klimatskih uvjeta na osutost bukve ujedno ispitujući prikladnost pojedinih statističkih metoda. Istražit ćemo utjecaj klimatskih uvjeta na ishranu bukve biogenim makroelementima i odrediti da li se njihove koncentracije razlikuju u odnosu na osutost stabala. Naš je cilj također utvrditi postoje li povezanosti osutosti i debljinskog prirasta, uključujući mogući efekt kašnjenja. Konačno, fiziologija stresa obične bukve biti će istražena u kontroliranim uvjetima analizirajući fotosintezu, rast i ishranu sadnica u uvjetima sušnog stresa i za vrijeme oporavka od suše, upotpunjujući naša planirana istraživanja u bukovim sastojinama.Rezultati ovog projekta osigurati će podlogu za različite procese odlučivanja vezane uz gospodarenje šumama, usluge šumskih ekosustava, izvješćivanje o stanju šuma kao i planiranje u svrhu smanjenja posljedica klimatskih promjena. ]]></summary_hr><summary_en><![CDATA[Tree vitality or condition can be defined as the ability of a tree to assimilate, to survive stress and to react to changing conditions. Changing climate properties can be critical for the condition of trees, as they can bring about the disturbed water absorption and transport, and water deficits may cause inadequate nutrition of trees with a subsequent loss of tree vitality. The main goal of this project is to explore the impact of changing climate conditions on various indicators of tree vitality, as well as their possible interrelations.We will use national and Europe-wide data of common beech defoliation from ICP Forests program and complete this data by sampling foliage, soil and increment cores of common beech trees on Croatian ICP Forests Level I plots. Past climate data and climate projections will be used in the subsequent analysis.We aim to model temporal and spatial change of defoliation and determine the influence of climate conditions on common beech defoliation, thereby also testing the suitability of various statistical methods. Furthermore, our objectives are to investigate the influence of climate conditions on foliar mineral nutrition of common beech and determine whether foliar element concentrations differ according to defoliation. We will also establish the relationships between defoliation and radial growth as well as investigate whether defoliation has a lagged effect on radial growth. Finally, the stress physiology of beech will be investigated in a controlled environment by analyzing photosynthesis, growth and nutrition of potted plants under drought stress and during post-drought recovery, complementing the results of the mentioned exploratory research.We expect the results of this project to provide basis for various decision-making processes related to forest management, forest ecosystem services, forest status reporting and climate mitigation planning. ]]></summary_en></project><project>
<id>7295</id><title_hr><![CDATA[Koncept nepomičnog pola u numeričkom modeliranju Cosseratovog kontinuuma]]></title_hr><title_en><![CDATA[Fixed-pole concept in numerical modelling of Cosserats’ continuum]]></title_en><user_id>527</user_id><user_firstLast_name>Gordan Jelenić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-1732</code><acronim><![CDATA[FIMCOS]]></acronim><duration>01.01.2019 - 30.06.2023</duration><status>Završio</status><financ_value>131.395,58 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Temeljne tehničke znanosti, Brodogradnja, Građevinarstvo, Metalurgija, Strojarstvo, Zrakoplovstvo, raketna i svemirska tehnika, </scie_field_hr><scie_field_en>Basic engineering sciences, Naval architecture, Civil engineering, Metallurgy, Mechnical engineering, Aerospace, missile and space engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Građevinski fakultet u Rijeci]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Civil Engineering]]></institution_en><team_members_id>1014, 3167, 27510, 17756, 28914, 864842, 866591, 25238, </team_members_id><team_members_names><![CDATA[Dragan Ribarić, Edita Papa Dukić, Laura Žiković, Sara Grbčić Erdelj, Maedeh Ranjbar Zefreh, Magdy Ismail, Damjan Jurković, Marin Grbac, ]]></team_members_names><keywords_hr><![CDATA[Cosseratov kontinuum, opis metodom nepomičnoga pola, metoda konačnih elemenata, objektivnost, konzervativna integracija, identifikacija parametara]]></keywords_hr><keywords_en><![CDATA[Cosserats&#39; continuum, fixed-pole description, finite-element method, objectivity, conservative integration, parameter identification]]></keywords_en><summary_hr><![CDATA[U ovome projektnom prijedlogu razmatra se alternativna teorija kontinuuma poznata pod nazivom Cosseratova ili mikropolarna teorija. Predlaže se provedba detaljnije analize u okviru  takozvane metode nepomičnog pola s ciljem razvoja točnih i djelotvornih konačnih elemenata za linearnu i nelinearnu statičku i dinamičku analizu.Elementi će biti razvijeni slijedom niza istraživačkih ciljeva koji se sastoje od (O1) linearne statičke analize, (O2) nelinearne statičke analize, (O3) dinamičke analize i (O4) identifikacije parametara. Na taj način, putem ciljeva O1-O3 razvijeni elementi će tvoriti simulacijski alat sami za sebe, dok će putem cilja O4 stvoriti neophodni preduvjet za robusnu i pouzdanu proceduru potrebnu za identifikaciju materijalnih parametara iz eksperimentalnih mjerenja. Konačni elementi će biti provjereni putem niza standardnih testnih primjera, a par eksperimentalnih postava bit će projektiran da zaključi cilj O4. Ciljevi će biti dosegnuti kroz niz istraživačkih, edukacijskih i upravljačkih aktivnosti koje će voditi članovi projektne grupe i koji će se bazirati na ranijim dostignućima grupe u razvoju konačnih elemenata uključujući vezanu interpolaciju, objektivnu interpolaciju ovisnu o konfiguraciji, algoritme za vremensku integraciju, Cosseratovu elastičnost, metodu nepomičnog pola u nelinearnim gredama i iskustvo u provedbi beskontanog mjerenja. Konačni elementi će biti razvijeni unutar programa za analizu metodom konačnih elemenata FEAP.S projektnim rezultatima upoznat ćemo eksperte i širu javnost putem raznih diseminacijskih kanala, uključujući objave u znanstvenim časopisima najviše kategorije u području računske mehanike, predstavljanja na uglednim specijaliziranim konferencijama, kao i predavanja s ciljem populariziranja projektnoga istraživanja i znanosti općenito.]]></summary_hr><summary_en><![CDATA[An alternative continuum theory called Cosserats’ or micropolar theory is considered within this proposal and a case is made for its more thorough analysis within the framework of the so-called fixed-pole description with the aim of providing accurate and efficient finite elements for linear and non-linear static and dynamic analysis. The elements will be developed by pursuing a set of research objectives consisting of (O1) linear static analysis, (O2) non-linear static analysis, (O3) dynamic analysis and (O4) parameter identification. In this way, through objectives O1-O3 the elements developed will be usable as a simulation tool in their own right while in O4 they will make a vital pre-requisite for a robust and reliable procedure needed for identification of material parameters from experimental measurements. The finite elements will be tested against a number of bench-mark problems, while a couple of experimental setups will be designed to complete O4.The objectives will be reached through a series of research, training and management activities led by the members of the project team and built on previous achievements of the team in finite-element design involving linked interpolation, objective configuration-dependent interpolation, time-stepping algorithms, conventional Cosserats&#39; elasticity, fixed-pole approach in geometrically exact beams as well as experience in performing contactless measurements. The finite elements will be developed within the finite-element-analysis programme FEAP.The project results will be communicated to the professionals and general public through a variety of dissemination channels involving publications in the scientific journals of the highest rank within the area of computational mechanics, presentations at highly reputable thematic conferences, and lectures aimed at popularising the project research and science in general.]]></summary_en></project><project>
<id>7304</id><title_hr><![CDATA[Preuređivanje memorije: Manipuliranje T-staničnom memorijom u svrhu unapređenja učinkovitosti cjepiva]]></title_hr><title_en><![CDATA[]]></title_en><user_id>19051</user_id><user_firstLast_name>Felix Wensveen</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-2835</code><acronim><![CDATA[T-MEMORY]]></acronim><duration>02.07.2018 - 01.07.2020</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Medicine]]></institution_en><team_members_id>19748</team_members_id><team_members_names><![CDATA[ Doktorand: Inga Kavazović ]]></team_members_names><keywords_hr><![CDATA[T Stanična memorija, infekcija, rak, Eomes, T stanični receptor]]></keywords_hr><keywords_en><![CDATA[T cell memory, infection, cancer, Eomes, T cell receptor]]></keywords_en><summary_hr><![CDATA[Imunost posredovana CD8 T-limfocitima pruža nam zaštitu od brojnih patogena i tumora. Naivni repertoar limfocita T se sastoji od milijuna različitih klonova koji se međusobno razlikuju po specifičnosti svojih T-staničnih receptora. Prilikom infekcije, samo neki od klonova postaju dugovjeke memorijske stanice. Selekcijski proces odabira memorijskih klonova reguliran je ravnotežom između specifičnosti i raznolikosti kako bi se osigurao učinkovit sekundarni odgovor te mogućnost prepoznavanja istih, mutiranih antigena. Mehanizmi koji kontroliraju raznolikost memorije još uvijek nisu razjašnjeni. Naša grupa je prepoznala Eomes kao ključni transkripcijski čimbenik za formiranje memorije, no kako pojačana ekspresija Eomesa rezultira stvaranjem imunološke memorije je idalje nepoznato.	U ovom projektu, istražit ćemo utjecaj intenziteta signala i aktivacije T-staničnog receptora na formiranje memorije putem Eomes-a. Prvo ćemo ispitati kako razlike u jačini stimulacije utječu na kvantitativnu i kvalitativnu aktivaciju glavnih nizvodnih komponenti te način na koji se taj signal prevodi u određenu razinu ekspresije Eomes-a. Paralelno, proučavat ćemo i način na koji Eomes pretvara taj aktivirajući signal određene jačine u molekularni proces koji rezultira stvaranjem imunološke memorije. U trećoj fazi projekta utvrditi ćemo ključne čimbenike koji posreduju tim procesima. Još bitnije, usredotočit ćemo se na čimbenike koji mogu imati terapeutsku primjenu kako bi testirali učinkovitost specifičnog ciljanja tih molekula na unaprjeđenje antitumorskih i antivirusnih cjepiva.	Ovdje predstavljeni projektni prijedlog, osim iznimne inovativnosti, ima velike izglede za uspjeh budući da se temelji na velikoj količini preliminarnih rezultata. Uz to, jedna od ključnih prednosti je i naše dugogodišnje iskustvo i rad u području imunologije i istraživanja na životinjama. Stoga držimo da je ovaj projekt izvrsna investicija u hrvatsku akademsku zajednicu koja pomaže razvoju nove istraživačke grupe.]]></summary_hr><summary_en><![CDATA[CD8 T cell mediated immunity protects us against pathogens and cancer. The naive T cell pool consists of millions of clones, each one unique based on its T cell receptor (TCR). Upon infection, only a few of these clones are recruited to generate antigen-specific memory. Selection of memory clones is a trade-off between specificity and diversity to ensure both an efficient recall response and recognition of a sufficient number of targets. Mechanisms controlling memory diversity are largely unclear. Recently, we have identified the transcription factor Eomes as a key mediator of memory formation. How Eomes induction results in shaping of the memory cell pool is currently unknown.  	In this project, we will study the impact of activating T cell receptor signal intensity on memory formation via the transcription factor Eomes. First, we will investigate how TCR signal strength impacts the quality and quantity of activation of its main downstream components and how this translates into the activation of Eomes. In parallel, we will investigate how Eomes translates TCR-activating stimuli of a given strength in a molecular process that promotes memory formation. Using the combined information of these two lines of inquiry, we will identify and validate key factors that mediate these processes in the third phase of the project. Importantly, we will select for molecules that can be targeted by pharmacological means. Finally, we will test the potency of therapeutic intervention for the improvement of antiviral and anti-cancer vaccines. 	The proposal described here is both innovative, and has a high chance of success, since it is based on a large amount of preliminary data. This project builds on the strengths that our department has developed in the fields of immunology and animal research, while adding a fresh impulse of innovation. We therefore believe that this project is a solid investment in Croatian academia and aids in the development of a strong new research group. ]]></summary_en></project><project>
<id>7309</id><title_hr><![CDATA[Izračun antropometrijskih mjera pametnim telefonom i tabletom]]></title_hr><title_en><![CDATA[Smartphone and Tablet Extraction of Anthropometric Measurements]]></title_en><user_id>6456</user_id><user_firstLast_name>Tomislav Pribanić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-8118</code><acronim><![CDATA[STEAM]]></acronim><duration>01.02.2019 - 31.01.2023</duration><status>Završio</status><financ_value>127.281,17 eur</financ_value><scie_area_hr>Tehničke znanosti, Biomedicina i zdravstvo, Društvene znanosti, </scie_area_hr><scie_area_en>Technological sciences, Biomedicine and health sciences, Social sciences, </scie_area_en><scie_field_hr>Računarstvo, Elektrotehnika, Tekstilna tehnologija, Kliničke medicinske znanosti, Kineziologija, </scie_field_hr><scie_field_en>Computer sciences, Electrical engineering, Textile technology, Clinical sciences, Kinesiology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>4325, 6749, 23587, 23795, 23675, 23773, 23805, 6641, 23726, 7674, 7677, 27996, 861754, </team_members_id><team_members_names><![CDATA[Slavenka Petrak, Stanislav Peharec, Simone Gasparini, Stefan Gumhold, Anita Busic, Yago Diez Donoso, Zhan Song, Tomislav Petković, Davor Šentija, Nicola D&amp;#39;Apuzzo, Joaquim Salvi, Kristijan Bartol, David Bojanić, ]]></team_members_names><keywords_hr><![CDATA[3D skeniranja tijela, antropometrija, 3D antropometrijski podaci, ljudska postura, karakteristične točke tijela, tablet,pametni telefon, računalni vid]]></keywords_hr><keywords_en><![CDATA[3D body scan measurement, anthropometry, 3D anthropometric data, human posture, body landmark detection, tablet, smartphone, computer vision]]></keywords_en><summary_hr><![CDATA[Izrada 3D modela iz fotografija je jedna od glavnih zadaća računalnog vida, grane umjetne inteligencije u području računalne znanosti koja istražuje metodologiju izdvajanja informacija iz digitalnih slika. Dobivanje kvalitetnih 3D modela više nije ograničeno na obradu i istraživanje korištenjem stolnih računala i/ili prijenosnih računala visokih performansi. Moderni i moćni pametni telefoni te tableti (mobilne platforme) također otvaraju mogućnosti definiranja novih metoda za 3D rekonstrukciju. Dotično istraživanje ima dva glavna dijela. Prvi dio odnosi se na razvoj i implementaciju učinkovitih 3D algoritama rekonstrukcije optimiranih za posebnosti mobilnih platformi. Proširivanje funkcionalnosti pametnog telefona ili tableta prema 3D uređaju za skeniranje je značajno ne samo s gledišta znanstvenog istraživanja već i za potencijalnu industrijsku primjenu (ekonomsko iskorištavanje). Stoga je drugi dio ovog rada usmjeren na procjenu antropometrijskih veličina uporabom 2D i 3D podataka s mobilnih platformi. Antropometrijska mjerenja su od velikog značaja širokoj skupini korisnika jer antropometrija danas igra važnu ulogu u industrijskom dizajnu, dizajnu odjeće, ergonomiji, medicini i arhitekturi gdje se statistički podaci o raspodjeli dimenzija tijela u populaciji koriste za optimizaciju različitih proizvoda i usluga.]]></summary_hr><summary_en><![CDATA[The generation of 3D models from still images has been a long term goal in computer vision, a branch of artificial intelligence in the field of computer science which explores the state machines and models for extracting information from the digital images. Acquiring high quality 3D models is no longer restricted to processing on desktop computers and high end laptops. Modern and powerful smartphones and tablets (mobile platforms) open up the possibilities designing new methods for 3D reconstruction. The scope of this work is twofold. First part concerns the development and implementation of the efficient 3D reconstruction algorithms optimized for the mobile platforms features. Extending smartphone or tablet functionality towards 3D scanning device is interesting both for the scientific research and for the industrial (economic) exploitation as well. Therefore, the second part of this work is aimed at estimation of anthropometric measurements combining 2D and 3D data from mobile platforms. Anthropometric measurements are of particular interest to a large group of beneficiaries since nowadays anthropometry plays an important role in industrial design, clothing design, ergonomics, medicine and architecture where statistical data about the distribution of body dimensions in the population are used to optimize various products and services.]]></summary_en></project><project>
<id>7310</id><title_hr><![CDATA[Pojavnost, patogenetska obilježja i klinički značaj donor-specifičnih HLA i ne-HLA protutijela u bolesnika s presađenim bubregom]]></title_hr><title_en><![CDATA[Frequency, pathogenic characteristics and clinical significance of donor-specific HLA and non-HLA antibodies in kidney transplant recipients]]></title_en><user_id>3838</user_id><user_firstLast_name>Mladen Knotek</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-4737</code><acronim><![CDATA[PoPAtPB]]></acronim><duration>02.11.2018 - 01.11.2022</duration><status>Prekinut</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Kliničke medicinske znanosti, Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Clinical sciences, Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>3058, 24127, 24145, 24143, 24140, 24152, 5638, 4404, 13626, 4204, 4175, 3902, 23494, 24158, 5934, 4118, 24147, 24154, 5341, 6247, 24228, </team_members_id><team_members_names><![CDATA[Renata Žunec, Bojana Šimunov, Snježana Šulc, Ivan Margeta, Branislav Čingel, NATALIJA MARTINEZ, Zorana Grubić, Bojana Maksimović, Željka Jureković, Lada Zibar, Ivan Neretljak, Danica Galešić Ljubanović, Ksenija Vučur, Mario Sučić, Dinko Škegro, Mihaela Gunjača, Marija Maskalan, Biserka Palfi, Katarina Štingl Janković, MARIJA BUREK KAMENARIĆ, Goran Radulović, ]]></team_members_names><keywords_hr><![CDATA[transplantacija bubrega, HLA sustav, ne-HLA protutijela, HLA protutijela, odbacivanje, imunosupresija]]></keywords_hr><keywords_en><![CDATA[kidney transplantation, HLA system, non-HLA antibodies, HLA antibodies, rejection, immunosuppression]]></keywords_en><summary_hr><![CDATA[Humoralna aloimunost je glavni patogeni imunološki mehanizam u transplantaciji bubrega. Anti-HLA i ne-HLA protutijela posreduju odbacivanje bubrega protutijelima. Zasebni doprinos pojedine od tih kategorija protutijela, kao i njihov mogući sinergističkin učinak nisu dovoljno istraženi. Također, novi pristupi tipizaciji tkiva, odn. tkivnoj nepodudarnosti temeljeni na analizi epleta trebao bi doprinijeti smanjenju učestalosti odbacivanja posredovanog protutijelima. Ovaj projekt bi trebao istražiti ishod transplantacije u ovisnosti o odbacivanju posredovanom protutijelima i ulozi HLA i ne-HLA protutijela. Trebao bi istražiti i povezanost nepodudarnosti u epletima s ishodom transplantacije. Projekt će rezultirati novim spoznajama o patogenezi odbacivanja, i informirat će stručnu zajednicu za buduće donošenje hrvatskih smjernica o HLA tipizaciji i imunološkom nadzoru prije i nakon transplantacije bubrega.]]></summary_hr><summary_en><![CDATA[Humoral alloimmunity is the major pathogenic mechanism in kidney transplantation. Anti-HLA antibodies, as well as non-HLA antibodies participate in kidney graft rejection and loss. However, contribution of a particular type of antibodies in graft rejection and their possible synergistic effect has not been suficiently expolred. Better HLA matching should decrease rate of antibody-mediated rejection. In this project we plan to explore eplet-based HLA matching and the role of complement-binding HLA and non-HLA antibodies in kidney graft outcome. This project will result in more knowledge on pathogenesis of antibody-mediated rejection and its role on long-term graft outcomes. It will also form basis for Croatian guidelines on HLA typing and immune pre- and post-transplant surveillance in kidney transplantation]]></summary_en></project><project>
<id>7312</id><title_hr><![CDATA[Molekularno prepoznavanje DNA:RNA hibridnih i višelančanih struktura u bioanalitičkim i in vitro sustavima]]></title_hr><title_en><![CDATA[Molecular recognition of DNA:RNA hybrid and multistranded structures in bioanalytical and in vitro systems]]></title_en><user_id>1214</user_id><user_firstLast_name>Marijana Radić Stojković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-4694</code><acronim><![CDATA[DNARNAHyB-MolBio]]></acronim><duration>01.10.2018 - 30.09.2022</duration><status>Završio</status><financ_value>127.015,73 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Interdisciplinarne prirodne znanosti, Kemija, Biologija, </scie_field_hr><scie_field_en>Interdisciplinary natural sciences, Chemistry, Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>2953, 2522, 23593, 5964, 1232, 23560, 3527, 2974, 3713, 26556, 865135, </team_members_id><team_members_names><![CDATA[Lidija-Marija Tumir, Renata Kobetić, Filip Šupljika, Ljubica Glavaš-Obrovac, Ivo Crnolatac, Corrado Tringali, Ranko Stojković, Sanja Tomić, Anamaria Brozović, Iva Zonjić, SURESH SHANMUGAM, ]]></team_members_names><keywords_hr><![CDATA[DNA:RNA hibridne i višelančane strukture, molekularno prepoznavanje, metode visoke propusnosti, potencijal vezanja, antproliferativna aktivnost]]></keywords_hr><keywords_en><![CDATA[DNA:RNA hybrid and multistranded structures, molecular recognition, high-throughput methods, binding potential, antiproliferative activity]]></keywords_en><summary_hr><![CDATA[DNA:RNA hibridne i višelančane strukture stvaraju se kao prijelazne strukture tijekom mnogih biološki važnih procesa ako što su replikacija DNA, transkripcija, replikacija telomera i virusa HIV. Stoga predstavljaju atraktivne mete za male molekule osobito zato što nema puno literaturnih izvora koji navode ligande sa selektivnim vezanjem na te mete. Za ispunjavanje glavnog cilja projekta, potraga za novim strukturnim motivima/spojevima sa preferencijalnim vezanjem na DNA:RNA hibridne i višelančane strukture u odnosu na regularne DNA i RNA dvolančane i jednolančane strukture, prvo moraju biti ispunjeni drugi ciljevi: formiranje biblioteke spojeva sa strukturnim motivom potrebnim za prepoznavanje ovih meta, uvođenje i primjena novih DNA i RNA meta (DNA:RNA hibridne i višelančane strukture) i metoda visoke propusnosti  (kompeticijska dijaliza, temperaturno mekšanje smjesa, RNaseH test) u područje istraživanja projektnog tima, koje bi omogućile brzi probir spojeva sa sposobnošću prepoznavanja tih meta. Slijedeći cilj je detaljno istražiti način vezanja izabranih kompleksa ligand-DNA/RNA u bioanalitičkim sustavima (vodene puferirane otopine) pomoću spektroskopskih, kalorimetrijskih i komputacijskih metoda. Istražiti ćemo također moguću korelaciju između visokog veznog potencijala izabranih spojeva i antiproliferativne aktivnosti u kulturi stanica (MTT, protočna citometrija, konfokalna mikroskopija). Očekivani rezultati, ispunjavanje gore navedenih ciljeva, mogu se iskoristiti za: proširivanje osnovnog znanja u ovom području istraživanja, optimizaciju strukture spojeva s ciljem poboljšavanja njihove selektivnosti vezanja prema željenim DNA i RNA metama, moguću medicinsku primjenu, jačanje međuinstitucijske suradnje u Hrvatskoj i razvoj novih znanstvenih ekspertiza što će nama i našim suradnicima omogućiti publiciranje u časopisima visoke kvalitete.]]></summary_hr><summary_en><![CDATA[DNA:RNA hybrid and multistranded structures are formed as intermediate structures during many biologically important processes such as DNA replication, transcription, telomere replication and replication of HIV virus. Therefore, they represent attractive targets for small molecules, especially since the literature citations of the ligands with selective binding to these targets are scarce. To fulfill the main project goal, the search for new structural motives/compounds with preferential binding to DNA:RNA hybrid and multistranded structures vs. regular DNA and RNA duplexes and single-stranded structures, other aims have to be fulfilled first: forming a library of compounds, with structural motif necessary for interaction with these targets, introduction and implementation of new DNA and RNA targets (DNA:RNA hybrid and multistranded structures) and high-throughput methods (competition dialysis, thermal denaturation of mixtures, RNaseH assay) in the research study of our project team, which would enable fast screening of compounds for recognition of these targets. Another aim is to investigate in detail the mode of binding of selected ligand-DNA/RNA complexes in bioanalytical systems (aqueous buffered solutions) by spectroscopic, calorimetric and computational methods. Further, we will investigate the possible correlation between the strong binding potential of selected compounds and their antiproliferative activity in cell culture (MTT, flow cytometry, confocal microscopy).Expected results, fulfillment of the above-mentioned aims can be utilized for: broadening of the basic knowledge in the research area, optimisation of the ligands structure with the goal of improving the binding selectivity to desired DNA and RNA targets, possible medicinal use, strengthening of the inter-organizational collaboration in Croatia and development of novel research expertise that would enable publishing in quality scientific journals.]]></summary_en></project><project>
<id>7315</id><title_hr><![CDATA[Audio tehnologije u sustavima virtualne stvarnosti za primjenu u auralizaciji]]></title_hr><title_en><![CDATA[Audio Technologies in Virtual Reality Systems for Auralization Applications]]></title_en><user_id>3404</user_id><user_firstLast_name>Kristian Jambrošić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-6308</code><acronim><![CDATA[AUTAURA]]></acronim><duration>01.01.2019 - 31.03.2023</duration><status>Završio</status><financ_value>132.337,91 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, Interdisciplinarne tehničke znanosti, </scie_field_hr><scie_field_en>Electrical engineering, Interdisciplinary technological sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>19019, 1194, 12899, 962, 3612, 23979, 146, 856245, 21320, </team_members_id><team_members_names><![CDATA[Marko Horvat, Tin Oberman, Miljenko Krhen, Ivan Đurek, Tomislav Jagušt, Monika Rychtarikova, Antonio Petošić, Vedran Planinec, Petar Franček, ]]></team_members_names><keywords_hr><![CDATA[auralizacija, audio, virtualna akustika, virtualna stvarnost, binauralna sinteza, praćenje položaja glave]]></keywords_hr><keywords_en><![CDATA[auralisation, audio, virtual acoustics, virtual reality, binaural synthesis, head tracking]]></keywords_en><summary_hr><![CDATA[Auralizacija pronalazi sve više važnih primjena u svakodnevnom životu razvojem i lakom dostupnošću tehnologija i sustava virtualne stvarnosti. Projekt je fokusiran na istraživanje implementacije auralizacije na različitim sustavima, poglavito korištenjem binauralne tehnologije s dodanim sustavom za praćenje položaja glave. Uz dostupne komercijalne VR sustave, ispitati će se mogućnost uporabe povoljnih inercijskih senzora koji se dodaju jednostavnim ugradbenih sustavima kao alternativna inačica sučelja za auralizaciju radi dodavanja slušnog doživljaja u VR primjenama. Dodatno će se ispitati mogućnost korištenja široko rasprostranjenih pametnih telefona sa svojim već integriranim senzorima pokreta i smjera za potrebe auralizacije koristeći binauralnu tehnologiju. Navedeni sustavi izmjeriti će se i usporediti s obzirom na preciznost, latenciju i stabilnost, a ocijeniti će se i kvaliteta doživljaja prirodnosti virtualnog zvučnog polja na praktičnim primjerima auralizacije u laboratorijskom okruženju i u realnoj situaciji na terenu.]]></summary_hr><summary_en><![CDATA[Auralisation finds more and more important applications in everyday life by the development and broad availability of virtual reality technologies and systems. The project is focused on research of auralisation implementation in different systems, mainly by using binaural technology with an added head tracking system. Beside commercially available VR systems, the possibility of using inexpensive inertial measurement sensors added to simple embedded systems will be investigated as an alternative auralisation system for adding aural experience to VR applications. Additionally, the potential of using widely available smartphones with already integrated movement and direction sensors for auralisation purposes using binaural technology will be examined. The precision, stability and latency of the listed hardware platforms will be measured and compared, and the quality of immersion and naturalness of the virtual sound field in practical auralisation examples will be evaluated, both in laboratory and in-situ conditions.]]></summary_en></project><project>
<id>7318</id><title_hr><![CDATA[Hrvatski mrežni rječnik]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5199</user_id><user_firstLast_name>Lana Hudeček</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-6111</code><acronim><![CDATA[MREŽNIK]]></acronim><duration>01.09.2018 - 31.08.2021</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filologija, </scie_field_hr><scie_field_en>Philology, </scie_field_en><institution_hr><![CDATA[Institut za hrvatski jezik]]></institution_hr><institution_en><![CDATA[Institute of Croatian Language]]></institution_en><team_members_id>25202</team_members_id><team_members_names><![CDATA[ Doktorand: Josip Mihaljević ]]></team_members_names><keywords_hr><![CDATA[mrežni rječnik, hrvatski rječnik, jednojezični rječnik,  hipertekstni rječnik, e-leksikografija, e- rječnik, rječnik utemeljen na korpusu]]></keywords_hr><keywords_en><![CDATA[web dictionary, Croatian dictionary, monolingual dictionary,  hipertext dictionary; e-leksicography, e- dictionary, corpus based dictionary]]></keywords_en><summary_hr><![CDATA[U okviru projekta Hrvatski mrežni rječnik (MREŽNIK) izradit će se slobodno dostupan, jednojezični, hipertekstni, jednostavno pretraživ mrežni rječnik hrvatskoga standardnoga jezika od 10 000 natuknica koji će omogućivati interakciju s korisnicima. Natuknice i pojedine riječi i izrazi u rječničkim člancima povezivat će se unakrižno i s natuknicama u bazama podataka koje će nastati u okviru ovoga projekta (baza jezičnih savjeta, baza veznika s opisom vezničkih skupina i njihove modifikacije, baza objašnjenja podrijetla frazema, baza etnika i ktetika). Uz osnovne, rječnik će uključivati i školske definicije (3000) i definicije za strance (1000). Rječnik će biti utemeljen na kopusu (Hrvatska mrežna riznica i Hrvatski mrežni korpus). Uz te će se izvore uzimati u obzir pri uspostavi definicija, donošenju primjera i značenja i svi drugi dostupni tiskani i mrežni izvori. Rječnik će se pisati u programu TLex, prilagođenu za potrebe projekta, a za uvid u korpus upotrijebit će se mrežni alat za pretragu korpusa SketchEngine. Nakon završetka leksikografske obradbe, podatci će biti izvezeni iz TLexa te izrađena mrežna aplikacija rječnika. U okviru projekta predviđena je: 1. izradba temeljnoga rječnika od 10 000 natuknica; 2. izradba popratnih baza i njihovo povezivanje s temeljnim rječnikom; 3. povezivanje temeljnoga rječnika s drugim mrežnim izvorima koji se trenutačno izrađuju u Institutu za hrvatski jezik i jezikoslovlje (bazom glagolskih  valencija, kolokacija, hrvatskoga strukovnog nazivlja, Repozitorijem hratskih metafora, mrežnim stranicama Bolje je hrvatski (bolje.hr)); 4. izradba odostražnoga rječnika.MREŽNIK je zamišljen kao dinamični rječnik koji nakon završetka projektnoga razdoblja otvara mogućnost daljnjega dopunjivanja.]]></summary_hr><summary_en><![CDATA[As a part of the MREŽNIK (Croatian Online Dictionary) project, the online monolingual dictionary of Standard Croatian language with ten thousand dictionary entries will be compiled. The dictionary will be free, easy to search, it will allow interaction with users and will contain hypertext links. The dictionary entries will contain links to certain other words, expressions and repositories (Linguistic Advice Repository, Conjunction Repository, etc.). The dictionary will be corpus based (Croatian Language Repository and Croatian Web Corpus), but other sources, online and printed, will be taken into account when looking for example sentences and writing entry definitions.The dictionary will be compiled using TLex, a professional software application for compiling dictionaries. SketchEngine will be used to search the corpus. After the completion of the dictionary entries, the data will be exported from TLex, and the Web application will be developed.   The project will:1. compile the basic dictionary consisting of ten thousand entries;2. develope additional repositories and connect them with the basic dictionary; 3. connect the basic dictionary with other online resources which are currently being developed at the Institute of Croatian Language and Linguistics: (The Verb Valence Repository, The Collocation Repository, The Croatian Special Field Terminology of Croatian repository (Struna), The Etymological Dictionary of Croatian, The Croatian Metaphor Repository, website bolje.hr;4. compile a reverse dictionary.MREŽNIK is conceived as a dynamic dictionary, the development of which will not end at the end of the project.]]></summary_en></project><project>
<id>7319</id><title_hr><![CDATA[Izolacija i enkapsulacija bioaktivnih molekula samonikle i kultivirane koprive i komorača i učinci na fiziologiju organizma]]></title_hr><title_en><![CDATA[Isolation and encapsulation of bioactive molecules of wild and cultivated nettle and fennel and effects on organism physiology]]></title_en><user_id>1243</user_id><user_firstLast_name>Verica Dragović-Uzelac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-4924</code><acronim><![CDATA[PlantBioPower]]></acronim><duration>01.11.2018 - 31.10.2022</duration><status>Završio</status><financ_value>199.084,21 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Prehrambena tehnologija, Poljoprivreda, Nutricionizam, </scie_field_hr><scie_field_en>Food technology, Agriculture, Nutrition, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Food Technology and Biotechnology]]></institution_en><team_members_id>2644, 223, 2615, 1002, 1056, 1062, 1330, 3314, 23410, 3037, 23516, 5708, 25849, 855442, 13470, 3319, </team_members_id><team_members_names><![CDATA[Branka Levaj, IRENA LANDEKA JURČEVIĆ, Danijela Bursać Kovačević, Ivona Elez Garofulić, Zoran Zorić, Sandra Pedisić, Maja Repajić, Domagoj Đikić, Dyana Odeh, Igor Palčić, Sanja Radman, Ivanka Žutić, Valentina Kruk, Ena Cegledi, Marko Obranović, Nada Oršolić, ]]></team_members_names><keywords_hr><![CDATA[kopriva, komorač, bioaktivne molekule, biljni ekstrakti, eterična ulja, enkapsulacija, mikrobiom, mikotoksini]]></keywords_hr><keywords_en><![CDATA[nettle, fennel, bioactive molecules, plant extracts, essential oils, encapsulation, microbiome, mycotoxins]]></keywords_en><summary_hr><![CDATA[Kopriva (Urtica dioica L) i komorač (Foeniculum vulgare Mill) izvor su bioaktivnih molekula (BAM) (fitosteroli, karotenoidi, klorofili, terpenoidi, fenoli) smještenih u različitim dijelovima biljaka (nadzemni i podzemni). Rastu u prirodi kao samonikle ali se zbog postojanja brojnih kemotipova i varijabilnosti u kemijskom sastavu kultiviraju uz provođenje agrotehničkih mjera s ciljem dobivanja biljnog materijala ujednačene kvalitete.Zbog velikog broja BAM različitih molekulskih svojstava i farmakoloških učinaka (npr. antioksidacijsko, hipoglikemijsko, antivirusno, imunomodulacijsko djelovanje) mogu se koristiti u proizvodnji biljnih ekstrakata (BE) i eteričnih ulja (ETU) konvencionalnim te naprednim tehnikama ekstrakcije (npr. ASE; PHWE; MAE; SCO2 itd.). Dodatna stabilizacija BAM prisutnih u BE i ETU postiže se primjenom različitih postupaka enkapsulacije kojima se BAM inkorporiraju u zaštitni omotač nosača.Enkapsulacija omogućuje njihovu lakšu inkorporaciju u funkcionalne proizvode, naročito hidrofobnih i netopljivih molekula poput fitosterola, karotenoida, klorofila i sl. Također, BAM imaju značajan utjecaj na sastav mikrobioma crijeva te predstavljaju važan parametar u fiziološkoj modulaciji homeostaze organizma i osjetljivosti na bolesti.Stoga su ciljevi istraživanja:(i)definirati biološki potencijal samonikle koprive i komorača s različitih prirodna staništa te utvrditi utjecaj ishrane i agrotehničkih mjera na biosintezu BAM tijekom vegetacije; (ii)optimirati postupake proizvodnje BE i ETU te postupake enkapsulacije BE i ETU; (iii)odrediti djelovanje BAM koprive i komorača u prisutnosti mikotoksina na endogene probiotičke bakterije kolona, enzimsku aktivnost mikrobioma te posljedični tkivni i sistemski antioksidativni, antigenotoksični, metabolički, transkripcijski, upalni i imunosni odgovor domaćina; (iv)iznaći funkcionalne sastojake kao alternativni, ne-farmaceutski pristup u održavanju zdravlja i dobrobiti crijeva kroz promicanje crijevne mikrobne homeostaze.]]></summary_hr><summary_en><![CDATA[Nettle (Urtica dioica L.) and fennel (Foeniculum vulgare Mill) are rich source of bioactive molecules (BAM) (phytosterols, carotenoids, chlorophylls, terpenoids, phenols) located in different plant parts (over- and underground). They can be found as wild-grown, but because of a numerous chemotypes and variabilities, are being cultivated through various agrotechnical measures in order to obtain a uniform material. Due to the large number of BAMs of different properties and pharmacological effects (i.e. antioxidative, hypoglycemic, antiviral, immunomodulatory), they can be used for production of plant extracts (PE) and essential oils (EO) by conventional and novel extraction techniques (i.e. ASE; PHWE; MAE; SCO2 etc.). Their stabilization can be achieved by encapsulation where BAMs are incorporated into a protective wall material coating. Encapsulation provides easier incorporation of BAMs into functional products, especially for the hydrophobic ones (phytosterols, carotenoids, chlorophylls, etc.). Nevertheless, BAM have significant influence on the composition of intestinal microbiota and represent an important parameter in the physiological modulation of organism homeostasis and its susceptibility to diseases. Therefore, the aims of this research are to: (i) define the biological potential of wildf-grown nettle and fennel from different locations and to determine the influence of nutrition and agrotechnical measures on biosynthesis of BAM during vegetation; (ii) optimize PE and EO production and encapsulation procedures; (iii) determine the effect of nettle and fennel BAMs on endogenous probiotic colon bacteria in the presence of mycotoxins, microbial enzymatic activity and the consequent tissue and systemic antioxidative, antigenic, metabolic, transcriptional, inflammatory and immune response of the host; (iv) establish functional ingredients as an alternative, non-pharmaceutical approach to health care through promoting intestinal microbial homeostasis.]]></summary_en></project><project>
<id>7326</id><title_hr><![CDATA[Notch signaling in osteoclast progenitors induced by rheumatoid arthritis]]></title_hr><title_en><![CDATA[Notch signalni put u osteoklastnim progenitorima potaknutim reumatoidnim artritisom]]></title_en><user_id>3075</user_id><user_firstLast_name>Danka Grčević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-2414</code><acronim><![CDATA[NORA]]></acronim><duration>01.12.2018 - 30.11.2022</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, Clinical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>3895, 2978, 3882, 20922, 3604, 5107, 5110, 13283, 26491, 865162, 865435, </team_members_id><team_members_names><![CDATA[Alan Šućur, Vedran Katavić, Nataša Kovačić, Katarina Barbarić Starčević, Marina Ikić Matijašević, Zrinka Jajić, Ivo Kalajzić, Katerina Zrinski Petrovic, Masa Filipovic, Luka Minarik, Sara Aničić, ]]></team_members_names><keywords_hr><![CDATA[osteoclasts, arthritis, Notch, inflammation, progenitors, differentiation, cytokines, chemokines]]></keywords_hr><keywords_en><![CDATA[osteoklasti, artritis, Notch, upala, progenitori, diferencijacija, citokini, kemokini]]></keywords_en><summary_hr><![CDATA[Reumatoidni artritis karakteriziran je kroničnim upalnim odgovorom uz periartikularni i sustavni gubitak kosti uzrokovan pojačanom koštanom razgradnjom osteoklastima. S incidencijom od oko 1%, predstavlja značajan javnozdravstveni problem i pridonosi smanjenju kvalitete života. Osteokasti su velike multinuklearne stanice koje razgrađuju kost , a nastaju iz hematopoetskih stanica monocitno/makrofagne loze. Novije studije upućuju na moguću ulogu Notch signalnog puta u proliferaciji, diferencijaciji i migraciji stanica osteolastne loze. Međutim, točan mehanizam kako Notch signalni put djeluje u kontekstu artritisa nije poznat. Glavni cilj predloženog projekta je definirati ulogu Noch signalnog puta u proliferaciji, migraciji i diferencijaciji osteoklastnih progenitora u artritisu te testirati ima li manipulacija Notch signalnog puta učinak na aktivnost osteoklastnih progenitora i osteoresortivni potencijal.Korištenjem modela mišjeg artritisa izazvanog kolagenom (CIA) i uzoraka bolesnika s artritisom, cilj nam je razumjeti izražaj komponenti Notch sustava u pojedinim fazama tijekom diferencijacije osteoklasta i promjene izazvane artritisom, te učinke Notch-liganda na aktivnost osteoklastnih progenitora. Nadalje, planiramo testirati učinak inhibicije Notcha na proliferaciju, migraciju i diferencijaciju osteoklastnih progenitora in vitro. Kao in vivo model, primijenit ćemo neutralizacijska protutijela protiv Notcha i CreERT2 transgenične miševe u kojim će Notch signal biti inhibiran selektivno u osteoklastnim progenitorima koji izražavaju CX3CR1.Mišji CIA-model omogućit će praćenje i modulaciju razvoja bolesti uzrokovane pojačanom koštanom resorpcijom in vivo, dok će analiza ljudskih uzoraka omogućiti translaciju u kliničke uvjete. Karakterizacija Noch-signalnog puta u osteoklastnim progenitorima potaknutim artritisom pruža mogućnost razvoja terapijskih pristupa kojima će se kontrolirati njihova aktivnost, smanjujući time koštanu destrukciju uzorkovanu artritisom. ]]></summary_hr><summary_en><![CDATA[Rheumatoid arthritis (RA) is characterized by chronic inflammatory response as well as periarticular and generalized bone loss due to enhanced bone resorption by osteoclasts. With a prevalence of around 1%, it is an important contributor to public health burden and lower quality of life. Osteoclasts are large multinucleated bone-resorbing cells arising from monocyte/macrophage hematopoietic lineage. Recent evidences suggest the possible role of Notch signaling pathway in proliferation, differentiation and migration of osteoclast lineage cells. However, exact mechanism of how the Notch signaling works in the context of arthritis is largely unclear.The main goal of project proposal is to define the role of Notch signaling in osteoclast progenitor (OCP) proliferation, migration and differentiation in arthritis and to test if manipulation of Notch signaling has the effect on OCP activity and bone resorbing potential. Using the approach of mouse model of collagen-induced arthritis (CIA) and samples from arthritic patients, we aim to understand the stage specific expression of Notch system components during osteoclast differentiation and changes associated with arthritis, as well as the effects of Notch ligands on OCP activity. Furthermore, we plan to test the effect of Notch inhibition on OCP proliferation, migration and differentiation in vitro. As the in vivo model, we will utilize Notch inhibition by neutralizing antibodies and CreERT2 transgenic mouse model in which Notch signal is inhibited by tamoxifen injection selectively in CX3CR1-expressing OCPs.The mouse CIA model will enable us to monitor and modulate disease progression in the context of increased osteoresortion in vivo whereas the analysis of human samples will allow for the translation to the clinical settings. Characterization of Notch signaling in OCPs induced by arthritis could offer the potential to design therapeutic approaches to control their activity thus limiting bone destruction in arthritis.]]></summary_en></project><project>
<id>7328</id><title_hr><![CDATA[Zbrinjavanje mulja kroz proizvodnju energetskih kultura]]></title_hr><title_en><![CDATA[Sludge management via energy crops’ production]]></title_en><user_id>5606</user_id><user_firstLast_name>Neven Voća</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-7472</code><acronim><![CDATA[Mud4BioEnergy]]></acronim><duration>01.11.2018 - 31.10.2022</duration><status>Završio</status><financ_value>126.915,00 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, Biotehnologija, </scie_field_hr><scie_field_en>Agriculture, Biotechnology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Agronomski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Agriculture]]></institution_en><team_members_id>20300, 4927, 19006, 23630, 5608, 5589, 5600, 5604, 19643, 858338, 25226, 865134, </team_members_id><team_members_names><![CDATA[Milan Poljak, Tomislav  Karažija, Josip Leto, Hrvoje Kutnjak, Nikola Bilandžija, Tajana Krička, Vanja Jurišić, Ana Matin, Mateja Grubor, Jona Šurić, Anamarija Peter, Ivan Brandić, ]]></team_members_names><keywords_hr><![CDATA[Primjena mulja, energetske kulture, prinos, žetva, biogoriva]]></keywords_hr><keywords_en><![CDATA[Sludge application, energy crops,  yield,  harvest, biofuels]]></keywords_en><summary_hr><![CDATA[Prioritetna politika Europske unije jest da se mulj dobiven nakon pročistača otpadnih voda koristi na ekonomski optimalan način u poljoprivrednom sektoru te da se ukoliko je to moguće izbjegne njegovo spaljivanje. Zbrinjavanje mulja u poljoprivredi je definirano strogim propisima i direktivama koje nisu razdvojile njegovo korištenje u prehrambenoj ili neprehrambenoj proizvodnji. Postoje velike mogućnosti za napredak u isplativosti efikasne primjene mulja na tlo i to u količinama koje su veće od definiranih, bez ikakve opasnosti i mogućeg prodora štetnih tvari u okoliš. Naime, Pravilnikom o primjeni mulja u poljoprivrednoj proizvodnji u RH propisana je količina od najviše 1,66 tona suhe tvari mulja godišnje po hektaru poljoprivrednog zemljišta, bez obzira na vrstu poljoprivredne proizvodnje. Međutim, unatoč tim ograničenjima, kroz korištenje energetskih kultura postoji mogućnost obilnijeg korištenja mulja kao gnojiva. Procjene govore da bi se na taj način poljoprivredne površine višestruko reducirale u smislu intenzivnijeg zbrinjavanja mulja u poljoprivredi. Isto tako, idealno bi se korištenje mulja uklopilo upravo u proizvodnju energetskih kultura, koje bi bile oslobođene problema sa zdravstvenom reputacijom proizvoda. Ovom metodom mogla bi se iskoristiti tla lošije kvalitete i nepovoljnih agroklimatskih uvjeta koja ne mogu konkurirati u konvencionalnoj proizvodnji hrane. Zbog svega navedenog, kao idealne energetske kulture se nameću sterilna rizomatska trava Miscanthus x giganteus i biljka iz porodice sljezova Sida hermaphrodita. Cilj ovoga istraživanja analiza je biomase navedenih energetskih kultura, gnojenih različitim količinama mulja iz pročistača otpadnih voda, jednako u energetskom i ekološkom smislu. Isto tako, veliki izazov u uzgoju energetskih kultura leži u pravilnom odabiru datuma žetve, a samim time i smjeru korištenja biomase za potrebe proizvodnje različitih biogoriva.]]></summary_hr><summary_en><![CDATA[EU priority policy is a feasible utilization of sludge from wastewater treatment plant in the agricultural sector while avoiding its incineration. Sludge disposal in the agricultural sector is defined by strict regulations and directives which do not distinguish its utilization in food or non-food production. There is a great potential for improvement in terms of efficient sludge application to the soil, in larger quantities, without any danger or possible breaking of harmful substances into the environment. Regulations on the sludge application in agricultural production in Croatia is regulated by the amount of up to 1.66 t of sludge DM/year per ha of arable land, regardless of the type of agricultural production. However, despite these limitations, through the use of energy crops, there is a possibility of plentiful sludge use as a fertilizer. According to estimations, arable land will be greatly reduced in terms of intensive sludge management in agriculture in this way. Ideally, the use of sludge would fit right in the production of energy crops, which would be exempt from the problems with the healthy reputation of the product. Furthermore, this method could be used in lower quality soils and unfavorable climatic conditions that cannot compete with conventional food production. Consequently, sterile grass Miscanthus x giganteus and Mallow family plant Sida hermaphrodita are imposed as deal energy crops. The aim of this research is the analysis of those energy crops, fertilized with various quantities of sludge from the wastewater treatment plant. Also, a major challenge in energy crops growing lies in the proper selection of the harvesting date, as well as in choosing the optimal biofuel production pathway. ]]></summary_en></project><project>
<id>7329</id><title_hr><![CDATA[Klinički biomarkeri atopijskog dermatitisa]]></title_hr><title_en><![CDATA[Clinical biomarkers of atopic dermatitis]]></title_en><user_id>7190</user_id><user_firstLast_name>Branka Marinovic</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-5978</code><acronim><![CDATA[ADBIOMARK]]></acronim><duration>01.03.2019 - 28.02.2023</duration><status>Prekinut</status><financ_value>136.040,88 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo, Prirodne znanosti, </scie_area_hr><scie_area_en>Biomedicine and health sciences, Natural sciences, </scie_area_en><scie_field_hr>Kliničke medicinske znanosti, Kemija, </scie_field_hr><scie_field_en>Clinical sciences, Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>1261, 23634, 23524, </team_members_id><team_members_names><![CDATA[Ivone Jakaša, Suzana  Ljubojevic Hadzavdić, Ružica Jurakić Tončić, ]]></team_members_names><keywords_hr><![CDATA[atopijski dermatitis, imunološki biomarkeri, biomarkeri kožne barijere, filagrinske mutacije, molekularno profiliranje, prediktivni modeli]]></keywords_hr><keywords_en><![CDATA[atopic dermatitis, immunological biomarkers, biomarkers of skin barrier, filaggrin mutations, molecular profiling, predictive models]]></keywords_en><summary_hr><![CDATA[Atopijski dermatitis (AD) vrlo je česta kožna bolest s prevalencijom u djece od 15-30%, a u odraslih od 2-10%. Etiologija AD-a samo je dijelom razjašnjena, smatra se da bolest nastaje interakcijom okolišnih i genetskih čimbenika što dovodi do imunoloških poremećaja i oštećenja funkcije kožne barijere. Još uvijek ne možemo izliječiti bolesnike s AD, već bolest možemo držati pod kontolom ublažavanjem simptoma i produljavanjem razdoblja remisije. Trenutno ne postoji klasifikacija bolesti temeljem koje se može odrediti koji oblik terapije primijeniti, već se nakon provedene procjene težine bolesti u liječenju koristi višestepeni pristup što dodatno opterećuje kvalitetu života bolesnika ali i resurse našeg zdravstva. Glavni je cilj ove prospektivne kliničke studije identificirati biomarkere koji bi mogli biti od koristi za objektivnu procjenu težine bolesti i predviđanje odgovora na terapiju. Studija ce uključiti široki spektar genetskih i molekularnih čimbenika koji doprinose promjenama u kožnoj barijeri i imunološkom odgovoru kod AD-a. Istraživanje će biti usmjereno na neinvanzivne biomarkere koji se određuju u stratum corneumu (SC) koji će biti prikupljen pomoću adhezivnih traka. Biomarkeri iz SC omogućuju dobivanje informacija o kožnoj barijeri i imunološkim promjenama u koži, a, predstavljaju ciljne točke u liječenju primjenom lokalne i sistemske terapije. Značaj predložene studije je u tome što će uključiti široki raspon biomarkera relevantnih za patofiziologiju  AD-a određivanih u velikoj kohorti klinički dobro definiranih pacijenata s AD-om koje će se  prospektivno pratiti tijekom terapije. Biomarkeri bazirani na kliničkim, genetskim ili biokemijskim obilježjima doprinijeli bi objektivnosti i točnijoj procjeni aktivnosti bolesti, a time i podjelu u homogenije podgrupe s ciljem boljeg, individualnog pristupa u liječenju pacijenata sa AD-om što bi rezultiralo optimalnim omjerom koristi i rizika za bolesnika, ali i za zdravstveni sustav.]]></summary_hr><summary_en><![CDATA[Atopic dermatitis (AD), is the most prevalent skin disease with the life-time prevalence ranging between 15-30 % in children and 2-10 % in adults. Etiology of AD remains only partly understood but is believed to be multifactorial, most likely rooted in a complex interaction between environmental and genetic factors leading to immune deviation and impaired barrier function. At present AD cannot be cured and disease management is focused on improvement of symptoms and achievement of long-term disease control. With exception of disease severity which itself is challenging to quantify, at present there is no classifications which might be used to support decision on the type of therapy, and a multistep approach is followed imposing additional burden for patient’s quality of life and health care resources. The main objective of this prospective clinical study is to identify genetic, immunological and skin barrier biomarkers that can predict disease severity and treatment response in patients with AD. The focus will be on non-invasive biomarkers determined in the uppermost layer of the skin, stratum corneum (SC) collected by adhesive tapes. SC biomarkers also provide information on local immune milieu and skin barrier, both known as key components in AD pathophysiology as well as treatment targets for topical and systemic therapies. The strength of the proposed study is that it will include a wide range of biomarkers relevant for AD pathophysiology, which will be determined in a large cohort of clinically well-defined AD patients who will prospectively be followed during the therapy. Biomarkers based on clinical, genetic or biochemical features would enable more objective and accurate assessment of disease activity and furthermore stratification into more homogeneous subgroups aiming at personalized approach in treatment of AD with an optimal benefit/risk ratio for the patient and health care system.]]></summary_en></project><project>
<id>7330</id><title_hr><![CDATA[Temeljna elektronska svojstva novih kvantnih materijala: bezmaseni i korelirani fermion]]></title_hr><title_en><![CDATA[Fundamental electronic properties of new quantum materials: massless and correlated fermions]]></title_en><user_id>5009</user_id><user_firstLast_name>Ivan Kokanović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-8912</code><acronim><![CDATA[FEPNQMMCF]]></acronim><duration>01.10.2018 - 28.02.2023</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>1173, 3227, 17743, 23130, 6713, 4814, </team_members_id><team_members_names><![CDATA[Mario Novak, Mirko Baćani, Filip Orbanić, Bruno Gudac, Cooper John Robert, Zvonko Glumac, ]]></team_members_names><keywords_hr><![CDATA[Supravodljivost, bezmaseni i korelirani fermioni, topološki izolatori, Diracovi polumetali, Weyl polumetali]]></keywords_hr><keywords_en><![CDATA[Superconductivity, massless and correlated fermions, Topological insulators, Dirac semimetal, Weyl semimetal]]></keywords_en><summary_hr><![CDATA[U ovom projektu želimo primijeniti našu stručnost trendovima u fizici kondenzirane materije koji povezuju temeljna istraživanja s suvremenim tehnološkim razvojem. Stoga smo odabrali teme koje se bave električnim transportom, magnetskim, termoelektričnim kao i strukturnim i termodinamičkim svojstvima topoloških izolata, TI, Dirac i Weyl semimetal, DSM i WSM,  i supravodiči (visokotemperaturni kupratni supravodiči, VTS, i konvencionalni poremećeni supravodiči). Predloženi projekt nudi sveobuhvatna istraživanja od sinteze uzorka do interpretacije eksperimentalnih rezultata istraživanja. Cilj je proučiti kako se različiti parametri sinteze tih materijala odnose na njihove nanostrukturalne detalje i elektronske korelacije.   U području TI, DSM, WSM   će se sintetizirati novi materijali koje možemo koristiti za daljnje istraživanje i za suradnju s drugim znanstvenim grupama.  Rezultati u visokom magnetskom polju upućuju na snažne korelacijske efekte u ZrSiS-u, stoga pažljivom manipulacijom ove familije materijala kroz istraživanja učinka dopiranja, očekujemo da će se otkriti novi kvantni fazni prijelazi povezani s topološkom čvorom petljom, korelirani efekti  i  uređena stanja fermiona. U području tipa II Weylovih polumetala očekujemo uspješne sinteze visoko kvalitetnih monokristala nekoliko članova obitelji TaIrTe4, ugađanjem kompozicije, Fermijeva energija će se pomaknuti i omogućiti nam da promatramo svojstva ovih materijala. U polju VTS, primarni problem koji se želi riješiti u ovom projektu je postojanje elektronskih džepova u niskim magnetskim poljima uzrokovanih valovima gustoće naboja (CDW), u čistim YBa2Cu3O6+x monokristalima. Želimo istražiti termodinamičke dokaze CDW i magnetskih faznih prijelaza.  Konačno, poseban naglasak istraživanja će biti posvećen daljnjem razvoju novih metoda mjerenja specifične topline i magnetizacije na malim monokristalima koji su često najviše kvalitete. ]]></summary_hr><summary_en><![CDATA[In this project, we want to apply our expertise to the trends in condensed matter physics which link fundamental research with contemporary technological development. We have therefore selected topics that address electrical transport, magnetic, thermoelectric as well as structural, and thermodynamic properties, of topological insulators, TI,  Dirac and Weyl semimetals, DSM, WSM and superconductors (high-temperature cuprate superconductors, HTSC, and conventional disordered superconductors).  The proposed Project offers comprehensive research from sample synthesis to the interpretation of the experimental research results. The aim is to study how various parameters of synthesis of these materials relate to their nanostructural details and electronic correlations.In field of TI, DSM, WSM a useful new material will be synthesized which we can use for further study and for collaboration with other groups. The results in high magnetic field suggest that strong correlation effects are indeed present in ZrSiS, and with careful manipulation of this system through doping studies, novel transitions associated with the topological nodal loop may be realized as well as correlated fermion effects and ordered states will be revealed. In the field of type-II Weyl semimetals we expect to get high-quality single crystals of several members of TaIrTe4 family, by tuning the composition, the Fermi energy will be shifted and allow us to observe the material properties. In the field of HTSC, the primary issue addressed in this project is the existence of electron pockets in low magnetic fields caused by charge density waves (CDW) in pure YBa2Cu3O6+x single crystals. At the same time we will look for thermodynamic signatures of the CDW and magnetic phase transitions. Finally, a particular emphasis of the research will be the further development of novel apparatus to measure the specific heat and magnetisation of small single crystals which are often of the highest quality.   ]]></summary_en></project><project>
<id>7337</id><title_hr><![CDATA[Diofantska geometrija i primjene]]></title_hr><title_en><![CDATA[Diophantine geometry and applications]]></title_en><user_id>3767</user_id><user_firstLast_name>Matija Kazalicki</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-1313</code><acronim><![CDATA[DIOPHANT]]></acronim><duration>12.10.2018 - 11.10.2022</duration><status>Završio</status><financ_value>123.468,71 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>95, 1262, 1264, 23916, 23830, 1312, 1267, 1348, 2990, 4086, 1251, 23950, 23281, 23964, 23962, 23763, 2910, 17746, 865211, </team_members_id><team_members_names><![CDATA[Andrej Dujella, Alan Filipin, Ana Jurasić, Goran  Drazic, Daniel Kohen, Sanda Bujačić Babić, Ivica Gusić, Ivan Soldo, Tomislav Pejković, Nikola Adžaga, Petra Tadić, Ivan Krijan, Vinko Petričević, Antonela Trbović, Tomislav Gužvić, Bartosz Naskrecki, Filip Najman, Marija Bliznac Trebješanin, Petar Orlić, ]]></team_members_names><keywords_hr><![CDATA[Diofantove m-torke, eliptičke krivulje, modularne forme, Diofantske aproksimacije, kriptografija]]></keywords_hr><keywords_en><![CDATA[Diophantine m-tuples, elliptic curves, modular forms, Diophantine approximations, cryptography]]></keywords_en><summary_hr><![CDATA[Predloženi projekt će koordinirati i podržati istraživačke aktivnosti hrvatske grupe iz teorije brojeva. Teme istraživanja su: Diofantove m-torke i primjene, diofantske aproksimacije (separacija korijena, p-adski verižni razlomci), eliptičke krivulje i modularne forme. Nedavno su Dujella, Kazalicki, Mikić i Sziksai pokazali da postoje beskonačno mnogo racionalnih Diofantovih šestorki, te riješili problem koji je bio otvoren još od vremena Eulera. Planiramo proučiti geometriju tih šestorki kako bi utvrdili postojanje racionalnih Diofantovih sedmorki. Ti će rezultati biti korišteni za konstrukciju familija eliptičkih krivulja visokog ranga i fiksne torzije. Važan alat za proučavanje Mordell-Weil grupa je algoritam za injektivnost preslikavanja specijalizacije koju su razvili Gusić i Tadić koje namjeravamo generalizirati. Planiramo dokazati neke posebne slučajeve slutnje o regularnosti Diofantovih četvorki i proučavati taj fenomen u parametarskim familijama. Također ćemo razmotriti generalizacije na prstenove cijelih brojeva u poljima kao i općenitije D (n) -m-torke. Freitas, Le Hung i Siksek su nedavno dokazali da su sve eliptičke krivulje nad realnih kvadratnim poljima modularne. Planiramo proučavati modularnost na potpuno realnim kubnim poljima. Kazalicki i Kohen nedavno su otkrili vezu između ranga eliptičnih krivulja i nultočki pridruženih modularnih formi (mod p). Planiramo ovo dalje proučiti i povezati s rezultatima Mazur i Swinnerton-Dyer o analitičkom rangu eliptičkih krivulja. Najpopularniji kriptosustav s javnim ključem danas u upotrebi je RSA. Proučavajući diofantske aproksimacije planiramo razviti neke učinkovite napade na ovaj kriptosustav. Rezultati istraživanja bit će objavljeni u uglednim časopisima i predstavljeni na međunarodnim konferencijama. Ovim će se projektom produbiti naše znanstvene veze s međunarodnim grupama iz teorije brojeva te uvesti mlade znanstvenike u istraživanje.]]></summary_hr><summary_en><![CDATA[The proposed project will coordinate and support research activities of Croatian number theory group. The topics of research are: Diophantine m-tuples and applications, Diophantine approximations (root separation, p-adic continued fractions), elliptic curves and modular forms. Recently, Dujella, Kazalicki, Mikić and Sziksai showed that there are infinitely many rational Diophantine sextuples, and solved the problem that was open from the time of Euler. We plan to study the geometry of these sextuples to determine the existence of rational Diophantine septuplets. These results will be used for the construction of families of elliptic curves of high rank and fixed torsion. An important tool for studying Mordell-Weil groups is the algorithm for the injectivity of the specialization map developed by Gusić and Tadić which we plan to generalize. We plan to prove some special cases of regularity conjecture for Diophantine quadruples, and to study it in parametric families. Also, we will consider generalisations to the rings of integers of number fields, and to more general D(n)-m-tuples. Freitas, Le Hung and Siksek recently proved that all elliptic curves over real quadratic fields are modular. We plan to study the modularity over totally real cubic fields. Kazalicki and Kohen recently discovered the connection between the ranks of elliptic curves and zeros of associated modular forms (mod p). We plan to study this further, and connect it to the results of Mazur and Swinnerton-Dyer on the analytic rank of elliptic curves. The most popular public key cryptosystem in use today is the RSA. Studying Diophantine approximations, we plan to develop some efficient attacks on this cryptosystem. The results of the research will be published in respectable journals and presented on international conferences. Through this project we will intensify our scientific connections with international number theory groups and introduce young researchers to the research in number theory.]]></summary_en></project><project>
<id>7341</id><title_hr><![CDATA[Metabolomski pristupi u otkrivanju novih biomarkera i dubinska fenotipizacija u bolestima bubrega i srca pasa]]></title_hr><title_en><![CDATA[Metabolomic approaches to novel biomarker discovery and deep phenotyping in kidney and cardiac diseases of dogs]]></title_en><user_id>801</user_id><user_firstLast_name>Vladimir Mrljak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-8324</code><acronim><![CDATA[MetaDog]]></acronim><duration>12.11.2018 - 11.11.2022</duration><status>Završio</status><financ_value>126.020,31 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Veterinarska medicina, </scie_field_hr><scie_field_en>Veterinary medicine, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Veterinarski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Veterinary Medicine]]></institution_en><team_members_id>23757, 2779, 19047, 2720, 23647, 6734, 6678, 24078, 19049, 5882, 6338, 6240, 6965, 25377, </team_members_id><team_members_names><![CDATA[Andrea Tumpa, Anita  Horvatić, Guillemin Nicolas, Blanka  Beer Ljubić, David Eckersall, Josipa Kuleš, Martina Crnogaj, Burchmore Richard, Asier Galan, Alan Kovacevic, Jose Ceron, Jelena Gotić, Renata Barić Rafaj, Ivana Rubić, ]]></team_members_names><keywords_hr><![CDATA[ Metabolomika, Biomarkeri, Bubreg, Srce, Pas   ]]></keywords_hr><keywords_en><![CDATA[ Metabolomics, Biomarkers, Kidney, Heart, Dog]]></keywords_en><summary_hr><![CDATA[Metaboliti u serumu ili urinu mogu predstavljati biomarkere u otkrivanju bolesti, često i prije razvoja bolesti. Metabolomikom se identificiraju promijenjeni metaboliti u krvi i urinu. Vrlo malo istraživanja provedeno je na psima u cilju procjene potencijala metabolomike u dijagnostici. Metabolomskim pristupom će se istražiti metaboliti kao biomarkeri, u dvije česte i teške bolesti pasa: (a) protozoarnu bolest - babezioza s komplikacijom akutne ozljede bubrega (AKI) i (b) idiopatsku dilatacijsku kardiomiopatiju (iDCM).Ciljevi projekta su: otkrivanje novih biomarkera poremećaja funkcije bubrega i srca primijenom metabolomskih tehnika u analizi seruma i urina pasa s (a) nekompliciranim i kompliciranim oblikom babezioze,  (b) dijagnozom iDCM; određivanje učinka terapije Imizol u na metabolite u babeziozi; bolje razumijevanje  signalizacijski puteva u patogenezi ovih bolesti;  korištenje individualiziranih metaboličkih otisaka u terapiji prilagođenoj pacijentu.Napredne &#39;&#39;omika&#39;&#39; metode, tekućinska kromatografija, masena spektrometrija (LC-MS / MS) i plinska kromatografija (GC) -MS kombinirat će se s inovativnim metodama bioinformatike i biostatistike u dubinskoj analizi (dubinska fenotipizacija), obradom mnogobrojnih metabolomskih podataka.  Očekuje se da će rezultati pridonijeti    (a) identifikaciji promjena metabolita u infekciji  B. canis kao i novih biomarkera AKI i (b) ranoj dijagnostici  iDCM kod pasa, pri čemu će identificirani biomarkeri pridonijeti individualiziranom liječenju pacijenata. Metabolomika će pridonijeti razvoju veterinarske kliničke medicine prepoznavanjem novih biomarkera i terapijskih ciljeva lijekova, te doprinijeti širenju upotrebe ove metode u veterinarskoj medicini u Hrvatskoj. Znanstveni rezultati poboljšat će dijagnozu, prognozu i terapiju babezioze i iDCM-a. Dugoročno, uvođenje metabolomike u kliničku medicinu Veterinarski fakultet će se profilirati kao vodeća ustanova u &#39;&#39;omika&#39;&#39; područjima istraživanja na prostorima jugoistočne Europe.]]></summary_hr><summary_en><![CDATA[Metabolites in serum or urine are can act as biomarkers, detecting disease often before the development of illness. Metabolomics, identifies altered metabolites in blood and urine. In the dog there have been few investigations to assess the potential of metabolomics in diagnosis. Here a metabolomic approach will investigate metabolite biomarkers in two common and serious diseases of dogs; (a) the infectious disease of Babesiosis and acute kidney injury (AKI) and (b) non-infectious idiopathic dilated cardiomyopathy (iDCM). The goals of the project are to discover novel biomarkers of kidney and cardiac malfunction by metabolomics analysis of the sera and urine of dogs with (a) uncomplicated and complicated form of babesiosis, as well (b) dogs with diagnosed iDCM; to determine the effect of therapy for Babesiosis with the ImizolR, on metabolites; to understand pathway signalling in pathogenesis of these diseases; to use individual metabolomics fingerprints in tailored therapy. Advanced omics methods of liquid chromatography and mass spectrometry (LC-MS/MS) and gas chromatography (GC)-MS will be combined with innovative bioinformatics and biostatistics methods for in depth analysis (deep phenotyping) of the the rich metabolomics data from MS platforms.The results are expected to identify (a) metabolite change from B. canis infection and novel biomarkers of AKI and (b) early diagnosis of iDCM in dogs. Identified biomarkers will yield personalization of individual patient’s treatment. The impact of metabolomics will enhance veterinary clinical medicine by identification of biomarkers and therapeutic drug targets, spearheading the use of metabolomics in veterinary medicine in Croatia. The scientific results will improve the diagnosis, prognosis and therapy of babesiosis and iDCM.  For the long-term, introduction of metabolomics into clinical veterinary medicine will consolidate the Faculty of Veterinary Medicine as the leader in veterinary -omics research in SE Europe]]></summary_en></project><project>
<id>7342</id><title_hr><![CDATA[Monitoring rezistentnosti štetnika: nove metode detekcije i učinkovite strategije upravljanja rezistentnošću]]></title_hr><title_en><![CDATA[]]></title_en><user_id>12674</user_id><user_firstLast_name>Renata Bažok</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-2824</code><acronim><![CDATA[MONPERES]]></acronim><duration>02.07.2018 - 31.12.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Agronomski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Agriculture]]></institution_en><team_members_id>24311</team_members_id><team_members_names><![CDATA[ Doktorand: Martina Kadoić Balaško ]]></team_members_names><keywords_hr><![CDATA[biotest, metode detekcije, genetski monitoring, geometrijsko morfometrijska analiza, rezistentnost štetnika, upravljanje rezistentnošću]]></keywords_hr><keywords_en><![CDATA[ bioassay, detection methods, genetic monitoring, geometric morphometric analyse, pest resistance, restitance management strategies                   ]]></keywords_en><summary_hr><![CDATA[Proizvodnju važnih kultura u Hrvatskoj (kukuruz, krumpir i jabuka) ugrožavaju brojni štetnici, od kojih su najvažniji kukuruzna zlatica (Diabrotica virgifera virgifera LeConte) (WCR), krumpirova zlatica (Leptinotarsa decemlineata Say) (CPB) i jabukov savijač (Cydia pomonella L.) (CM). Navedene vrste razvile su rezistentnost na insekticide ili na strategije suzbijanja. Sustavno praćenje rezistentnosti štetnika u Hrvatskoj ne postoji. Za dokazivanje rezistentnosti uobičajeno se koriste biotestovi, biokemijski i molekularni testovi koji imaju određene prednosti, ali i nedostatke.Opći cilj predloženog projekta je otkriti i pratiti rezistentne populacije štetnika u Hrvatskoj, optimizirati genetske metode i istražiti pouzdanost geometrijsko-morfometrijskih metoda u otkrivanju rezistentnosti, te održati učinkovito suzbijanje uporabom odgovarajućih antirezistentnih strategija usmjerenih na najvažnije štetnike ratarskih (WCR, CPB) i voćarskih (CM) kultura.Specifični ciljevi projekta su:O1) u poljskim uvjetima Hrvatske organizirati sustavni monitoring rezistentnosti CPB i CM; O2) optimizirati genetske metode za otkrivanje varijabilnosti povezanih s razvojem rezistentnosti WCR, CPB i CM;O3) istražiti mogućnost korištenja geometrijsko-morfometrijskih metoda za otkrivanje razvoja rezistentnosti istraživanih štetnika;O4) utvrditi mogućnost korištenja alternativnih metoda suzbijanja; O5) osigurati prijenos znanja i spoznaja do ključnih interesnih skupina. Očekivani rezultati: R1) osigurani pouzdani podaci o pojavi i distribuciji rezistentnih populacija CPB i CM u Hrvatskoj; R2) istražene, razvijene i optimizirane genetske i R3) geometrijsko-morfometrijske metode za otkrivanje i praćenje nerezistentnih i rezistentnih populacija CPB, WCR i CM; R4) osigurani podaci o alternativnim (uključujući nekemijske) metodama i strategijama suzbijanja i R5) stečena znanja i spoznaje predočene interesnim skupinama. Osigurana potpora provedbi novo razvijenih strategija u poljoprivrednu praksu.]]></summary_hr><summary_en><![CDATA[The production of the important crops, maize, potato and apples in Croatia is endangered by many of insect pests out of which very important are Western corn rootworm (Diabrotica virgifera virgifera LeConte) (WCR), Colorado potato beetle (Leptinotarsa decemlineata Say) (CPB) and Codling moth (Cydia pomonella L.) (CM). These pests have shown resistance to insecticides or to management strategies. No systematic monitoring of pest resistance is carried out in Croatia. Methods available for resistance detection  (bioassays, biochemical or molecular) have positive and negative points. The main objective is to detect and monitor the resistant variants in Croatia, optimize genetic and explore reliability of morphometric based survey techniques for the detection of resistance, and to maintain effective control using appropriate resistance manageemnt strategies of WCR, CPB and CM. Specific objectives are: O1) to conduct systematic field monitoring of resistance in CPB  and CM in Croatia; O2) to optimize techniques to detect genetic differentiation correlated with resistance development in WCR, CPB and CM; O3) to explore the potential of geometric morphometric techniques in order to detect resistance development in investigated pests;O4) to establish the potential for use of alternative control options for investigated pests.O5) to disseminate gained knowledge to key stakeholders The expected results are: R1 provided reliable data on the presence and distribution of resistant variants of CPB and CM in Croatia; R2) The genetic and R3) morphometric based survey techniques to detect and monitor the movement of non-resistant and resistant variants of CPB, WCR and CM explored, developed and optimized; R4) the summarized information on alternative (including non-chemical) control options and strategies provided and R5) The gained knowledge disseminated to key stakeholders. Provided support to implementation of newly developed strategies into the agricultural practice.]]></summary_en></project><project>
<id>7343</id><title_hr><![CDATA[Metodološki okvir za učinkovito upravljanje energijom s pomoću inteligentne podatkovne analitike]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6717</user_id><user_firstLast_name>Dario Šebalj</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-5414</code><acronim><![CDATA[MERIDA]]></acronim><duration>24.09.2018 - 31.01.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, </scie_field_hr><scie_field_en>Economy, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Ekonomski fakultet u Osijeku]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Economics]]></institution_en><team_members_id>25355</team_members_id><team_members_names><![CDATA[ Doktorand: Marinela Knežević ]]></team_members_names><keywords_hr><![CDATA[podatkovna analitka, strojno učenje, energetska učinkovitost, troškovi energije, lanac opskrbe, simulacije, metodološki okvir]]></keywords_hr><keywords_en><![CDATA[data analytics, machine learning, energy efficiency, energy cost, energy supply chain, simulation, methodological framework]]></keywords_en><summary_hr><![CDATA[Iako u Hrvatskoj i u drugim zemljama EU postoje strategije i nacionalni planovi energetske učinkovitosti kojima se određuju i prate ciljevi smanjenja potrošnje energije,  podaci se nedovoljno znanstveno analiziraju u svrhu učinkovitijeg upravljanja energijom, a posebice nedostaje uporaba metoda strojnog učenja. Upravo je svrha projekta provesti inteligentnu analizu podataka o energetskoj učinkovitosti zgrada u javnom sektoru, ponuditi metode i modele koji bi omogućili bolje planiranje nacionalne energetske politike te upravljanje troškovima. Ciljevi projekta su: (1) identificirati karakteristične skupine (klastere) javnih zgrada za koje se prate energetske karakteristike, mjere za poboljšanje tih karakteristika i potrošnja energije, (2) uporabom podatkovne analitike razviti metodološki okvir za  predviđanja i analizu utjecaja pojedinih varijabli na uštede u potrošnji energije, emisiji CO2 i troškovima, (3) naprednim analitičkim metodama procijeniti financijsku isplativost i dugoročne financijske učinke mjera za povećanje energetske učinkovitosti i (4) simulacijskim modeliranjem predložiti prilagodbe modela lanca opskrbe prirodnog plina kao jednog od važnijih energenata u javnom sektoru. Za dobivanje modela testirat će se metode strojnog učenja, kao što su klaster analize, neuronske mreže, stabla odlučivanja, metoda potpornih vektora i druge, zatim financijske metode, mapiranje lanca opskrbe i simulacijsko modeliranje. Statističkim testovima izabrat će se metode koje generiraju preciznije modele i predložiti njihova integracija u nov metodološki okvir kao znanstveni doprinos projekta.  Osim toga, otkrit će se utjecaj pojedinih ulaznih varijabli na potrošnju energije i trošak te stvoriti jedinstvena baza podataka energetske učinkovitosti koja će služiti i za buduće analize. Osim istraživača, korisnici ovog projekta mogu biti državne institucije davatelji subvencija, donositelji i provoditelji energetske politike, korisnici zgrada i pružatelji energetskih usluga.]]></summary_hr><summary_en><![CDATA[Although there are strategies and national plans of energy efficiency in Croatia and other EU countries, which determine and monitor the objectives of reducing energy consumption, the data have not been scientifically analyzed enough for the purpose of efficient energy management, and there is a lack of machine learning methods usage.  The purpose of the project is to conduct an intelligent data analysis on public buildings energy efficiency, and to suggest methods and models that will enable better planning of national energy policy. The aims of the project are: (1) to identify characteristic clusters of public buildings for which data on energetic characteristics, measures for improving those characteristics, and energy consumption are captured, (2) to develop a methodological framework for predictions and analyses of variable influence on energy consumption, CO2 emission and cost, by using intelligent data analytics,  (3) to estimate financial compensation and long-term financial effects of measures for increasing energy efficiency by advanced analytical methods, and (4) to suggest improvements in supply chain of natural gas as one of the important energy sources in building sector. In order to obtain models, methods of machine learning will be tested such as cluster analysis, neural networks, decision trees, support vector machines, and others, as well as financial methods, supply chain mapping, and simulation modelling.  By using statistical tests, the more successful methods will be suggested for integration in the methodological framework that will be the major scientific contribution. In addition, the influence of specific input variables on energy consumption and cost will be revealed, and a unique database of energy efficiency will be established that could be used for future data analyses. Besides researchers, the users of this project could be state institutions providers of subventions, policy makers, managers in public sector, and energy providers.]]></summary_en></project><project>
<id>7345</id><title_hr><![CDATA[Napredni nositelji energije u oporabi plastičnog otpada]]></title_hr><title_en><![CDATA[Smart energy carriers in recovery of plastic waste]]></title_en><user_id>2536</user_id><user_firstLast_name>Daniel Rolph Schneider</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-3200</code><acronim><![CDATA[NEOPLAST]]></acronim><duration>01.01.2019 - 31.12.2022</duration><status>Završio</status><financ_value>132.617,64 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Interdisciplinarne tehničke znanosti, Kemijsko inženjerstvo, Strojarstvo, </scie_field_hr><scie_field_en>Interdisciplinary technological sciences, Chemical engineering, Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>17796, 23650, 12978, 23756, 23752, 12861, 24013, 864831, 864830, 913, 25819, </team_members_id><team_members_names><![CDATA[Tihomir Tomić, Mladen Šercer, Boris Ćosić, Petar  Gvero, Saša Papuga, Davor Ljubas, Robert Mikulandric, Maja Fabulić Ruszkowski, Iva Sanja Beer Romac, Zlata Hrnjak-Murgić, Irma  Kremer, ]]></team_members_names><keywords_hr><![CDATA[plastični otpad, iskorištavanje energije, gorivo iz otpada, piroliza, isplinjavanje, utjelovljena primarna energija]]></keywords_hr><keywords_en><![CDATA[plastic waste, energy recovery, waste-to-fuel, pyrolysis, gasification, embedded primary energy]]></keywords_en><summary_hr><![CDATA[Zbrinjavanje plastičnog otpada postaje sve veći problem u svijetu pa tako i u Hrvatskoj, pri čemu veliki dio tog materijala završi na odlagalištima ili se akumulira u prirodnom okolišu. Iako su prednosti materijske oporabe (recikliranja) veće, ne mogu se sve količine plastičnog otpada zbrinuti na taj način zbog različitih tehničkih, ekonomskih ili ekoloških razloga.U ovom se projektu, između ostalih, razmatraju i inovativne tehnologije za valorizaciju otpadne plastike kao alternativnog izvora energije i goriva, poput postupaka pirolize, isplinjavanja ili katalitičkih procesa depolimerizacije. Svi relevantni postupci sagledavaju se s tehničkih, okolišnih i socio-ekonomskih aspekata. Istraživanje se provodi kombinacijom različitih modelskih alata u svrhu simulacije različitih lanaca plastičnog otpada od njegovog nastanka do konverzije u energiju, goriva i druge produkte kao i njihove optimizacije u cilju lakše integracije u postojeće sustave gospodarenja otpadom i sustave proizvodnje energije. Pri tome se koristi višekriterijski pristup, od analize materijskih tokova, analize utjelovljene primarne energije i indeksa kumulativne potrošnje energije, do procjene cjeloživotnog vijeka.U okviru projekta provodi se mapiranje dostupnih količina i vrsta otpadne nereciklabilne plastike na prostoru RH. Formirat će se i klaster zainteresiranih tvrtki iz industrije koje mogu imati koristi od provedenih istraživanja. Unutar klastera definirat će se potencijalni pilot-projekti zasnovani na nekoj od naprednih tehnologija energetske konverzije. Za razmatrane procese kod odabranih studija slučaja provest će se numeričko modeliranje, s eksperimentalnom validacijom. Vezano uz to biti će napravljene laboratorijske analize uzoraka ulaznog otpada kao i izlaznog produkta, a za same procese biti će urađena energetska, eksergo-ekonomska i detaljna LCA analiza procesa. Naposljetku će se napraviti tehno-ekonomska analiza s procjenom isplativosti predloženih rješenja za odabrane realne slučajeve.]]></summary_hr><summary_en><![CDATA[Disposal of plastic waste is becoming increasingly problematic in the world as well as in Croatia, where a large part of this material ends up in landfills or accumulates in a natural environment. Although the benefits of material recovery (recycling) are higher, not all the quantities of plastic waste can be disposed on that way because of different technical, economic or ecological reasons.In this project, among others, innovative technologies for the valorisation of waste plastics as alternative energy and fuel, such as pyrolysis, gasification or catalytic depolymerization processes, are also considered. All relevant methods are reviewed from the technical, environmental and socio-economic aspects. The research is carried out by a combination of different model tools for the simulation of various plastic waste chains from its emergence to conversion into energy, fuels and other products as well as their optimization in order to facilitate integration into existing waste management and energy production systems. This involves a multi-criteria approach, from material flow analysis, embedded primary energy analysis, and cumulative energy consumption index to life cycle analysis.Within the project, the mapping of the available quantities and types of unrecyclable waste plastic in the Republic of Croatia is being carried out. A cluster of interested companies from industry that could benefit from the research will be formed. Within the cluster, potential pilot projects will be defined based on one of the advanced energy conversion technologies. Numerical modeling, with experimental validation, will be performed for the selected processes in the case studies. Furthermore, laboratory analyses of samples of input plastic waste and output products-fuel, and for the processes will be carried out the energetic, exergo-economic, and detailed LCA analysis. Finally, a techno-economic analysis will be carried out with the estimation of the feasibility for selected real cases.]]></summary_en></project><project>
<id>7346</id><title_hr><![CDATA[Derivati harmina kao potencijalni antimalarici]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6183</user_id><user_firstLast_name>Zrinka Rajić Džolić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-4042</code><acronim><![CDATA[CLICKforMALARIA]]></acronim><duration>01.09.2018 - 31.12.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Farmaceutsko-biokemijski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Pharmacy and Biochemistry]]></institution_en><team_members_id>25221</team_members_id><team_members_names><![CDATA[ Doktorand: Marina Marinović ]]></team_members_names><keywords_hr><![CDATA[malarija, harmin, sinteza, antimalarijsko djelovanje, citotoksičnost, studije metabolizma]]></keywords_hr><keywords_en><![CDATA[malaria, harmine, synthesis, antimalarial activity, citotoxicity, metabolic studies]]></keywords_en><summary_hr><![CDATA[Malarija je smrtonosna bolest tropskih i subtropskih krajeva koja se prenosi ubodom komarca, a uzrokovana je parazitima roda Plasmodium. Cjepivo protiv malarije ne postoji, kao ni učinkovito uništavanje prijenosnika malarije. Osim toga, pojava otpornosti vrsta Plasmodium na postojeće lijekove dovodi do neučinkovitosti sadašnje terapije i zahtijeva otkriće lijekova s novim mehanizmima djelovanja. Alkaloidi b-karbolinskog tipa prisutni su u biljkama Peganum harmala i Eurycoma longifolia, koje se više od 2 tisućljeća koriste u tradicionalnoj kineskoj medicini za liječenje malarije i karcinoma. Djelatne supstancije ekstrakta biljke su alkaloidi harmin, harmalin, harmalol i harman. In vitro i in vivo studije pokazale su da harmin posjeduje snažno antimalarijsko djelovanje. Njegov mogući mehanizam djelovanja je inhibicija proteina toplinskog šoka 90 iz P. falciparum, koji je nužan za normalni razvoj parazita i ima važnu ulogu u razvoju rezistencije na postojeće antimalarike. U ovom projektu predviđeno je dizajniranje i sinteza knjižnice spojeva, koji se sastoje od harmina i 1) derivata cimetne kiseline (harmicini), 2) poznatih antimalarika: klorokina i meflokina (harmikini) i 3) ferocena (harmoceni). U sva tri tipa predviđenih spojeva poveznica će biti 1H-1,2,3-triazol, koji se pokazao korisnim u pripravi različitih biološki aktivnih spojeva. Predviđeni spojevi pripravit će se uobičajenim metodama sintetske organske kemije, te korištenjem modernih pristupa, &#39;&#39;click&#39;&#39; kemije i sinteze uz pomoć mikrovalova.Sintetiziranim spojevima ispitat će se antimalarijsko djelovanje in vitro, na eritrocitnu i hepatocitnu fazu plazmodija, te citoksično djelovanje na humane stanične linije. Uz to, provest će se studije metabolizma biološki aktivnih spojeva.Konačni rezultat projekta biti će novi spojevi učinkoviti protiv rezistentnih sojeva roda Plasmodium. Najaktivniji spojevi biti će polazišna točka za budući razvoj inovativnih lijekova.]]></summary_hr><summary_en><![CDATA[Malaria is a deadly mosquito-borne tropical and subtropical disease, caused the parazite of the genus Plasmodium. There is neither available vaccine, nor reliable vector control. In addition, Plasmodium is developing resistance to the existing therapy, which urges the discovery of novel drugs with new mechanisms of action.Alkaloids of b-carboline type are present in the medicinal plants Peganum harmala and Eurycoma longifolia, which have been used in the traditional Oriental medicine for the treatment of cancer and malaria. The active ingredients were identified as harmine, harmaline, harmalol and harman. In vitro and in vivo studies have proven harmine&#39;s antimalarial activity. Its possible mechanism of action is selective inhibition of P. falciparum heat shock protein 90, which is crucial for the parazite development and may play a major role in drug resistance. In the proposed project we decided to focus on the design and synthesis of a compound library, comprising harmine and 1) cinnamic acid moiety (harmicines), 2) known antimalarial drugs: chloroquine or mefloquine (harmiquines) and 3) ferrocene scaffold (harmocenes). The final compounds will incorporate 1H-1,2,3-triazole scaffolds, which proved to be useful in the synthesis of various biologically active compounds. Standard methods of synthetic organic chemistry, as well as modern approaches, such as click chemistry and microwave assisted synthesis will be employed. Antimalarial activity of the prepared compounds will be evaluated in vitro on both erythrocytic and hepatic stage of the Plasmodium, as well as cytotoxycity against human cell lines. In addition, metabolism studies for the biologically active compounds will be performed. As a final result, we will provide new candidate therapeutics against drug-resistant malaria parasite. The most active compounds will offer a valuable starting point for future development of innovative medicines.]]></summary_en></project><project>
<id>7352</id><title_hr><![CDATA[Modeliranje mentalne gramatike hrvatskoga: ograničenja informacijske strukture]]></title_hr><title_en><![CDATA[]]></title_en><user_id>12893</user_id><user_firstLast_name>Anita Peti-Stantić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-5567</code><acronim><![CDATA[MEGAHR/MEGACRO]]></acronim><duration>01.10.2018 - 30.09.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filologija, </scie_field_hr><scie_field_en>Philology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>25299</team_members_id><team_members_names><![CDATA[ Doktorand: Vedrana Gnjidić ]]></team_members_names><keywords_hr><![CDATA[mentalna gramatika, informacijska struktura, računalno modeliranje, psiholingvistika, paralelna arhitektura, jezična kompetencija]]></keywords_hr><keywords_en><![CDATA[mental grammar, information structure, computational modeling, psycholinguistics, parallel architecture, language competence]]></keywords_en><summary_hr><![CDATA[Osnovni je cilj projekta Modeliranje mentalne gramatike hrvatskoga: ograničenja informacijske strukture odrediti gradivne sastavnice informacijske strukture mentalne gramatike hrvatskoga. Na temelju korpusnog i psiholingvističkog pristupa istražit ćemo načine procesiranja morfosintaktičkoga i semantičkoga slaganja konkretnih i/ili apstraktnih leksičkih jedinica u koordiniranim i eliptičnim strukturama, kao i načine procesiranja informacijske strukture rečenice s obzirom na smještaj klitika. Na temelju toga ćemo odrediti skup nužnih, univerzalnih kao i jezičnospecifičnih obrazaca koji određuju informacijsku strukturu hrvatskoga, na morfosintaktničkoj i na semantičkoj razini. Usredotočit ćemo se na lokalna (linearna) i globalna (hijerarhijska) ograničenja procesiranja u mentalnoj gramatici hrvatskoga. Teorijske posljedice takvoga pristupa vidjet će se u mogućnosti razvijanja modela jezičnoga procesiranja, kao i za određivanje i uspostavljanje veza između globalnih i lokalnih gradivnih elemenata mentalne gramatike hrvatskoga. Na praktičnoj će razini projekt kroz kurikularnu obnovu pridonijeti poboljšanju produktivne jezične kompetencije u okvirima obrazovnog sustava. Kako bismo ostvarili ove ciljeve, provest ćemo tri vrste aktivnosti: 1) na temelju korpusa hrWaC uspostavit ćemo korelaciju između kategorija konkretnosti i predočivosti za 3000 leksičkih jedinica kao i za skup gramatičkih jedinica (zamjeničkih i glagolskih klitika); 2) uspostavit ćemo odnos između konretnosti i slaganja (s obzirom na rod, elipsu i smještaj klitika); 3) odredit ćemo specifične obrascie potrebne za izgradnju komunikacijski učinkovitih mreža riječi i gramatičkih struktura u hrvatskom obrazovnom sustavu.Metodološka inovativnost istraživanja ogleda se u povezivanju teorijski informiranog kvalitativnog i kvantitativnog psiholingvistički relevantnog istraživanja koje će omogućiti uspostavu prediktivne leksičke analize na razini korpusa, kao i na razini gramatičkih obrazaca mentalne gramatike.]]></summary_hr><summary_en><![CDATA[The goal of the project The Building Blocks of Croatian Mental Grammar: Constraints of Information Structure is to determine the building blocks of the information structure of Croatian mental grammar. Specifically, based on corpus and psycholinguistic research, we will look into how speakers process morphosyntactic and semantic agreement of concrete and/or abstract lexical items in coordinated constructions and elliptical conditions, as well as how they process sentence information structure with regard to complex clitic cluster positioning. Thus, we will determine a set of necessary, universal and language-specific patterns that represent the requirements determining the information structure in Croatian, both on the morphosyntactic and the semantic level. We are predominantly interested in local (linear) and global (hierarchical) processing constraints within the mental grammar of Croatian. Our approach will have theoretical consequences for developing a model of language processing, as well as identifying and correlating global and local building blocks of mental grammar of Croatian. On the practical level, we seek to improve the productive linguistic competence of pupils in the education system. This will be operationalized through three main activities: (1) psycholinguistically establishing a correlation between concreteness and imageability for a set of high and low frequency lexical and grammatical items (clitics) based on corpus data; (2) psycholinguistically establishing the relationship between concreteness and agreement (in gender, ellipsis and clitic cluster positioning); (3) establishing language-specific patterns for building effective word and grammar webs within the educational system. Methodological novelty is reflected in connecting a theoretically-based qualitative and quantitative psycholinguistic research with a corpus study, which will enable the establishment of a predictive lexical analysis, as well as grammatical patterns in mental grammar.]]></summary_en></project><project>
<id>7359</id><title_hr><![CDATA[Nanokompoziti s perovskitima za fotovoltaike, fotokatalizu i senzoriku]]></title_hr><title_en><![CDATA[Nanocomposites comprising perovskites for photovoltaics, photo-catalysis and sensing]]></title_en><user_id>3922</user_id><user_firstLast_name>Andreja Gajović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-5246</code><acronim><![CDATA[NanoPeroPhotoSens]]></acronim><duration>01.11.2018 - 31.10.2022</duration><status>Završio</status><financ_value>196.500,76 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, Kemija, </scie_field_hr><scie_field_en>Physics, Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>12522, 3932, 12524, 3012, 1271, 12832, 1338, 2580, 13228, 22501, 23623, 1529, 22804, 742, 2527, 18922, 28192, 861726, 864912, 26021, 865293, </team_members_id><team_members_names><![CDATA[Krunoslav Juraić, Milivoj Plodinec, Daniel Meljanac, Davor Gracin, Nikša Krstulović, Jelena Macan, Vilko Mandić, Igor Lukačević, Maja Varga Pajtler, Matko Mužević, Denis Stanić, Ivana Grčić, Marko Petric, Igor Petrović, Ivana Melnjak, Lucija Radetić, Tihana Čižmar, Vedran Kojić, Andreja Žužić, Mario Bohač, Ivan Kovač, ]]></team_members_names><keywords_hr><![CDATA[perovskitni oksidi, BaTiO3, oksidni perovskiti na bazi Mn, nanostructure, nanokompoziti, fotovoltaici, fotokataliza, senzorika]]></keywords_hr><keywords_en><![CDATA[perovskite oxides, BaTiO3, Mn-based oxide perovskites, nanostrucures, nanocomposites, photovoltaics, photo-catalysis, sensing]]></keywords_en><summary_hr><![CDATA[Projekt će biti nastavak istraživanja provedenih u prethodnom razdoblju, posvećenih mogućnosti podešavanja svojstava tankih filmova za uporabu u fotoosjetljivim uređajima, modificiranjem njihove strukture i sastava. Istraživati će se nano-strukture i nanokompoziti koji imaju poseban oblik, kao što su nanocjevčice, nano-štapići i vrlo tanki slojevi. Za dodatnu prilagodbu svojstava, modificirat će se kemijski sastav i struktura površine filmova elektrokemijskim jetkanjem, prekrivanjem nanočesticama i tretmanom u reaktivnim plinovima. Podrška eksperimentalnom radu u postizanju ciljanih svojstava za fotonaponsku, senzorsku i fotokatalitičku primjenu, bit će teorijska predviđanja temeljena na DFT računu elektronske strukture pojedinih materijala i nanokompozita. Eksperimenti na ZnO i TiO2, provedeni u prethodnom projektu, bit će prošireni na oksidne materijale koji imaju perovskitnu strukturu, počevši od BaTiO2 i perovskita na bazi Mn. U daljnjim koracima, funkcionalnost istraživanih tankih filmova će biti istražena njihovom integracijom u dvoslojne i višeslojne strukture relevantne za pojedinu vrstu fotoosjetljivih uređaja.Za pripravu i modifikaciju tankih filmova će se koristiti razne fizikalne i kemijske metode. Strukturna i funkcionalna svojstva će se određivati standardnim tehnikama i korelirati s parametrima formiranja, što će omogućiti bolji uvid u procese relevantne za rast tankog filma. Dobiveni eksperimentalni podaci, u kombinaciji s teorijskim predviđanjima temeljenim na DFT izračunima, rezultirati će boljim razumijevanjem utjecaja sastava i nanostrukture na makroskopska svojstva. Ovo će omogućiti procjenu u kojoj mjeri je moguće, postupcima korištenim u projektu, poboljšati svojstava fotovoltaika, fotokatalizatora i senzora. Dobiveni rezultati će biti objavljeni u časopisima s visokim faktorom odjeka iz područja znanosti o materijalima.Projekt će biti djelomično posvećen obrazovanju diplomskih i doktorskih studenata što podrazumijeva i razvoj novih karijera.]]></summary_hr><summary_en><![CDATA[Project will be continuation of research conducted in the previous period, devoted to exploring possibility of tailoring thin film properties by structural and compositional modification, for use in photosensitive devices. The nano-sized structures and nanocomposites with specific shape as nanotubes, nanorods and thin layers will be investigated. For additional adjustment of properties, the surface chemistry and structure will be modified by electrochemical etching, decoration with nanoparticles and treatment in reactive gases. The achievement of preferred properties targeting for the photovoltaic, sensing and photo-catalytic application will be supported by prediction of theoretical study, based on DFT calculation of electronic structure of individual materials and nanocomposites. The experiments on ZnO and TiO2, done in previous project, will be extended on oxide materials having perovskite structures, starting with BaTiO2 and Mn based perovskites. In further steps, the functionality of studied thin films will be tested by integration in bi-layer and multilayer structures as a part of photosensitive device.For preparation and modification of thin films, various physical and chemical methods will be used. Their structural and functional properties will be determined by using standard techniques and correlated with parameters of formation, enabling better insight into the processes relevant for the thin film growth. The obtained experimental data, combined with theoretical predictions based on DFT calculations, will lead to better understanding of the influence of composition and nanostructure on macroscopic properties. It will enable the evaluation of possibilities of using applied approaches for improving properties of photovoltaics, photo-catalysts and sensors. The results will be published in the high ranking journals in the field of material science.Project will be partially devoted to education of the graduate and PhD students implying new careers development.]]></summary_en></project><project>
<id>7360</id><title_hr><![CDATA[Nove geometrije za gravitaciju i prostor-vrijeme]]></title_hr><title_en><![CDATA[New Geometries for Gravity and Spacetime]]></title_en><user_id>5035</user_id><user_firstLast_name>Athanasios Chatzistavrakidis</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-7615</code><acronim><![CDATA[GRASP]]></acronim><duration>01.10.2018 - 28.02.2023</duration><status>Završio</status><financ_value>111.354,44 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>52, 1356, 23690, 23722, 25315, 25067, 29368, 865431, 865552, </team_members_id><team_members_names><![CDATA[Larisa Jonke, Zoran Škoda, Richard Szabo, Bergshoeff Eric, Georgios Karagiannis, Grgur Šimunić, Kökényesi Zoltan, Pantelis Panopoulos, Jan Rosseel, ]]></team_members_names><keywords_hr><![CDATA[Teorija struna, dualnosti u teoriji struna, ne-geometrijske jakosti polja, sigma modeli, Newton-Cartanova gravitacija]]></keywords_hr><keywords_en><![CDATA[String theory, string dualities, non-geometric fluxes, generalized geometry, sigma models, Newton-Cartan gravity]]></keywords_en><summary_hr><![CDATA[Kako pomiriti opću teoriju relativnosti i kvantnu mehaniku te opisati kvantnu strukturu prostor-vremena je jedan od glavnih izazova za teorijsku fiziku danas. Dva istaknuta okvira unutar kojih se taj problem rješava su teorija struna i nekomutativna geometrija. Nedavno ostvareni napredak u području ukazuje da zatvorene strune &#39;&#39;vide&#39;&#39; nekomutativnu i moguće neasocijativnu geometriju prostor-vremena. U okviru ovog projekta želimo produbiti naše razumijevanje same geometrije i gravitacijskog sektora teorije struna. Preciznije, istraživat ćemo propagaciju struna na pozadini koja uključuje ne-geometrijske jakosti polja koristeći matematičke metode nekomutativne i neasocijativne geometrije, Courantovih algebroida te generalizirane i više geometrije. Glavni cilj istraživanje je osigurati solidnu geometrijsku osnovu za teorije koje su invarijantne s obzirom na T- i U- dualnost, poput dvostruke teorije polje i izuzetne teorije polje, konstruirati gravitacijske modele koje uključuju poopćene jakosti polja te brane kao izvore i zatim istražiti fizikalne implikacije tih modela. Drugi cilj je usmjeran na istraživanje geometrijske strukture nerelativističkih teorija gravitacije koje u zadnje vrijeme privlače puno pažnje zbog primjena u raznim područjima fizike, od holografije, teorije kondenzirane tvari do teorije struna. Rezultati projekta će imati bitan utjecaj na naše razumijevanje gravitacijskih interakcija te će u višegodišnjoj perspektivi doprinjeti rasvjetljavnju pitanja začetka i strukture svemira.]]></summary_hr><summary_en><![CDATA[Reconciling general relativity and quantum mechanics and understanding the quantum structure of spacetime is one of the major challenges for present day theoretical physics. Two prominent frameworks addressing this conundrum are string theory and noncommutative geometry. Recent advances provide evidence that the generic spacetime geometries experienced by closed strings are noncommutative and even nonassociative. Within this project we aim at a deeper understanding of the geometry and the gravitational sector of string theory. In particular, we are going to study strings propagating in backgrounds with non-geometric fluxes, using mathematical tools such as noncommutative and nonassociative differential geometry, Courant algebroids, generalized and higher geometry. Our main goal is to provide a solid geometric basis for T- and U-duality-invariant theories, such as double field theory and exceptional field theories, elucidate the structure of string and membrane sigma models, construct models of gravity in the presence of general fluxes and brane sources and study their physical implications. A second goal is to investigate the geometric structure of non-relativistic gravity theories, which attract a lot of interest in recent years due to applications in diverse physical settings, ranging from holography and condensed matter physics to string theory. We expect that the results of this project will have an impact in our understanding of the gravitational interaction, and will contribute to the long-term goal of elucidating the origin and the structure of the universe. ]]></summary_en></project><project>
<id>7367</id><title_hr><![CDATA[Određivanje ključnih molekula epitelno-mezenhimalne tranzicije kao mogućih ciljeva za terapiju raka jajnika ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3713</user_id><user_firstLast_name>Anamaria Brozović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-8086</code><acronim><![CDATA[DEvOuT]]></acronim><duration>17.10.2018 - 29.01.2024</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>25301</team_members_id><team_members_names><![CDATA[ Doktorand: Margareta Pernar ]]></team_members_names><keywords_hr><![CDATA[Epitelno-mezenhimalna tranzicija, otpornost na lijekove, rak jajnika, miRNA-200, karboplatina]]></keywords_hr><keywords_en><![CDATA[epithelial-mesenchymal transition, drug resistance, ovarian cancer, miRNA-200, carboplatin]]></keywords_en><summary_hr><![CDATA[U najvećem broju slučajeva rak jajnika dijagnosticira se u uznapredovalom stadiju zbog čega je kemoterapija neuspješna. Kod bolesnica koje odgovore uspješno na terapiju čak u 70-80% bolest se ponovo javlja unutar godine dana. Prema tome, razvoj otpornosti na terapiju glavna je prepreka njene uspješnosti. Karboplatina (CBP) je jedan od lijekova prve linije terapije. Proces epitelno-mezenhimalna tranzicija (EMT) korelira s napredovanjem bolesti i metastaziranjem te otpornosti na terapiju. Literaturni podaci opisuju promjene različitih proteina i miRNA u tim procesima. Međutim, još uvijek nije poznato koje od tih molekula su uključene u oba procesa. U okviru naših preliminarnih istraživanja razvili smo nekoliko staničnih linija raka jajnika otpornih na CBP koje su prošle proces EMT, te u jednoj od njih identificirali smanjenu ekspresiju svih članova miRNA-200 obitelji za koje se iz literature zna da reguliraju ekspresiju mnogih proteina u stanici. Budući da se proces EMT i razvoj otpornosti događaju istovremeno naša je hipoteza da postoje ključne molekule koje se uključene u oba procesa te da bi se one mogle koristiti kao ciljne molekule za terapiju. Prvi cilj ovog projekta je u in vitro modelima kulture stanica pronaći ključne molekule (proteine na transkripcijskom i translacijskom nivou i miRNA) odgovorne za EMT i razvoj otpornosti na CBP i njihovu međusobnu povezanost. Uključenost svake od pronađenih molekula utvrdit će se odgovarajućim funkcionalnim testovima. Drugi cilj je utvrditi ekspresijski status pronađenih molekula u uzorcima tkiva bolesnica (normalno vs tumorsko) te korelirati pronađene promjene s odgovorom bolesnica na terapiju. Treći cilj je potvrditi važnost otkrivenih molekula u regulaciji EMT i razvoju otpornosti na CBP u modelu organoida. Ukupni cilj projekta je pronaći ključne molekule odgovorne za EMT i otpornost na CBP, te moguće korištenje tih molekula u  liječenju bolesnica oboljelih od raka jajnika.]]></summary_hr><summary_en><![CDATA[Most epithelial ovarian cancer patients are diagnosed with advanced-stage disease and do not respond to chemotherapy. About 70-80% of patients, who respond to the chemotherapy, experience a recurrence of cancer within months to years. Therefore the development of tumor drug resistance is the major problem for a successful therapy. Carboplatin (CBP) is one of the drugs in the first-line therapy. Epithelial-mesenchymal transition (EMT) correlates with cancer progression, metastasis and drug resistance. Literature data have shown changes in expression of different proteins and miRNA in these processes. However, it is still not known which molecules are involved in both of these processes. Our preliminary research resulted in establishment of several CBP resistant ovarian cancer cell lines that underwent EMT. In one of these cell lines we found decreased expression of miRNA-200 members, for which it has been known to regulate many different proteins in the cells. Since EMT and development of drug resistance have been shown to occur in the cell simultaneously, our hypothesis proposes the existence of key molecules involved in both of these processes making them valuable therapy targets. The first goal of this project is to determine key molecules (proteins at transcriptional and translation levels and miRNA) involved in EMT and development of drug resistance and to confirm their role by using functional tests. The second goal is to establish the expression pattern of these molecules in tissue samples from patients with ovarian cancer (normal vs tumor) and to correlate these changes with the patient response to the therapy. The third goal is to confirm the importance of identified molecules in EMT and drug resistance development by using organoids culture. The overall goal of this project is to find key molecules involved in EMT and development of drug resistance and to investigate the possibility of using them as targets for ovarian cancer therapy.]]></summary_en></project><project>
<id>7368</id><title_hr><![CDATA[BlueMed]]></title_hr><title_en><![CDATA[]]></title_en><user_id>667</user_id><user_firstLast_name>Melita Peharda Uljević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-9373</code><acronim><![CDATA[]]></acronim><duration>01.08.2018 - 31.10.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut za oceanografiju i ribarstvo]]></institution_hr><institution_en><![CDATA[Institute of Oceanography and Fisheries]]></institution_en><team_members_id>25078</team_members_id><team_members_names><![CDATA[ Doktorand: Hana Uvanović ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>7370</id><title_hr><![CDATA[Primjena inovativnih metoda u praćenju proteolitičkih, lipolitičkih i oksidativnih procesa tijekom proizvodnje pršuta]]></title_hr><title_en><![CDATA[]]></title_en><user_id>19625</user_id><user_firstLast_name>Helga Medić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-3240</code><acronim><![CDATA[IM-HQHAM ]]></acronim><duration>10.09.2018 - 09.09.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Prehrambena tehnologija, </scie_field_hr><scie_field_en>Food technology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Food Technology and Biotechnology]]></institution_en><team_members_id>25241</team_members_id><team_members_names><![CDATA[ Doktorand: Ivna Poljanec ]]></team_members_names><keywords_hr><![CDATA[pršut, proteoliza, oksidacija proteina, masena spektrometrija, lipoliza, aroma, senzorska analiza]]></keywords_hr><keywords_en><![CDATA[dry-cured ham, proteolysis, protein oxidation, mass spectrometry, aroma, sensory analysis]]></keywords_en><summary_hr><![CDATA[Primjena novih metoda masene spektrometrije u prehrambenoj tehnologiji omogućuje bolji uvid u biokemijske procese koji se odvijaju tijekom prerade hrane, a njihovi produkti utječu na kvalitetu i nutritivnu vrijednost prehrambenih proizvoda.  S obzirom da su proteini i masti osnovne komponente pršuta, imaju značajan utjecaj na nutritivnu vrijednost, a njihovom razgradnjom tijekom proizvodnog procesa nastaju spojevi odgovorni za teksturu, boju i aromu proizvoda. Znanstveno je utvrđeno da su glavne biokemijske reakcije koje se odvijaju tijekom proizvodnje pršuta proteoliza i lipoliza te su najnovija znanstvena istraživanja u svijetu intenzivno usmjerena na proteolizu i oksidaciju proteina zbog njihovog utjecaja na kvalitetu gotovog proizvoda. Brojni čimbenici koji proizlaze iz tehnološkog procesa proizvodnje utječu na intenzitet proteolitičkih, lipolitičkih i oksidativnih procesa. Stoga je cilj ovog projekta istražiti utjecaj brzine i opsega proteolitičkih, lipolitičkih i oksidativnih procesa na teksturu, boju i aromu finalnog proizvoda, prateći promjene na proteinima i lipidima kroz cijeli proizvodni proces, korištenjem inovativnih analitičkih metoda. Odredit će se  i identificirati proteini, peptidi i amino kiseline kao i proteolitički indeks te oksidacija proteina određivanjem ukupnih proteinskih karbonila. Paralelno s navedenim, odredit će se i oksidacija masti te sastav masnih kiselina, boja, osnovni kemijski sastav, koncentracija NaCl, proteinski i neproteinski dušik te tekstura pršuta. Rezultati ovog projekta pokazat će kako se primjenom novih metoda masene spektrometrije može utvrditi odnos između uvjeta prerade, biokemijskih procesa i teksture pršuta kako bi se osigurala visoka kvaliteta proizvoda. ]]></summary_hr><summary_en><![CDATA[The application of novel mass spectrometry-based methods in food technology provides better insight into the biochemical processes that occur during the processing and their products affect the quality and nutritional value of food. Proteins and fats are major components of dry-cured ham with significant impact on the nutritional value of the product. Through their degradation during the processing arise compounds responsible for the product texture, color and flavor. It has been scientifically established that the main biochemical reactions during the production of dry-cured ham are proteolysis and lipolysis and current scientific research studies are focused intensely on proteolysis and oxidation of proteins because of their impact on the quality of the final product. Numerous factors arising from the technological process influence the intensity of proteolytic, lipolytic and oxidative processes. Therefore, the aim of this project is to investigate the influence of proteolytic, lipolytic and oxidative changes on the texture, color and flavor of the final product by monitoring changes of the proteins and lipids throughout the dry-cured ham process using innovative analytical methods. Proteins will be identified, peptides and amino acids, proteolysis index, the oxidation of proteins and protein carbonyls will be analyzed. In parallel, the oxidation of fat and fatty acid composition, color, basic chemical composition, concentration of NaCl, protein and non-protein nitrogen and texture of the ham will be determined. The results of this project will show that the application of novel mass spectrometry-based methods can help in defining the relationship among processing conditions, the biochemical processes and the texture of dry-cured ham to ensure high quality product.]]></summary_en></project><project>
<id>7371</id><title_hr><![CDATA[Klimatske promjene i invazivne vrste – utvrđivanje utjecaja na bioraznoliost nativnih slatkovodnih rakova i pastrva i njihova konzervacija]]></title_hr><title_en><![CDATA[]]></title_en><user_id>12634</user_id><user_firstLast_name>Ivana Maguire</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-9589</code><acronim><![CDATA[CLINEinBIOta]]></acronim><duration>10.10.2018 - 09.10.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>25329</team_members_id><team_members_names><![CDATA[ Doktorand: Leona Lovrenčić ]]></team_members_names><keywords_hr><![CDATA[genetska varijabilnost, evolucijska povijest, Astacus astacus, Austropotamobius torrentium, Salmo trutta, modeli pogodnosti staništa]]></keywords_hr><keywords_en><![CDATA[genetic variability, evolutionary history, Astacus astacus, Austropotamobius torrentium, Salmo trutta, habitat suitability models]]></keywords_en><summary_hr><![CDATA[Slatkovodni su ekosustavi pod sve većim antropogenim pritiskom što negativno utječe na njihovu bioraznolikost, a time i na njihovo funkcioniranje te usluge koje pružaju. Bioraznolikost posebice ugrožavaju globalne klimatske promjene i unos stranih vrsta. Stoga je cilj ovog projekta istražiti njihov utjecaj na slatkovodne organizme. U fokusu predloženog projekta su tri slatkovodne zavičajne vrste (potočni i plemeniti rak, potočna pastrva) koje imaju ključnu ulogu u ekosustavima, osiguravaju njihovo normalno funkcioniranje (rakovi) i ekonomski su značajne (pastrve). Njihov nestanak iz staništa značajno mijenja slatkovodne ekosustave, dovodi do promjena u dinamici transporta sedimenta te uzrokuje promjene u sastavu zajednica. Ove su vrste osjetljivi na promjene u staništu, a zbog negativnog antropogenog utjecaja i sve izraženijih klimatskih promjena, ugrožene su i zaštićene međunarodnim i nacionalnim zakonima.Cilj predloženog projekta je istražiti genetsku varijabilnost odabranih populacija ove tri vrste upotrebom mitohondrijskih, nuklearnih i mikrosatelitnih DNA biljega i doprinijeti novim spoznajama o njihovoj evolucijskoj povijesti i nasljeđu te identificirati njihove evolucijski bitne jedinice i jedinice upravljanja. Isto tako cilj je razviti modele potencijalno pogodnih područja za invazivne vrste rakova i strane linije pastrva kako bismo mogli predvidjeti područja i zavičajne populacije koja će biti pod njihovim najvećim pritiskom u budućnosti. Nadalje, cilj je izraditi modele pogodnosti staništa za proučavane zavičajne vrste, te njihova projekcija u budućnost prema različitim scenarijima klimatskih promjena što će omogućit identifikaciju područja koja će biti izrazito nepogodna za njihovo preživljavanje, kao i područja koja će osigurati njihov dugotrajni opstanak. Očekujemo da će dobiveni rezultati poslužiti kao kvalitetna osnova za izradu adekvatnih konzervacijskih strategija i planova upravljanja s ove tri osjetljive i ključne vrste slatkovodnih ekosustava. ]]></summary_hr><summary_en><![CDATA[Freshwater ecosystems are under growing anthropogenic pressure that negatively influence onto their biodiversity, and consequently onto alteration of ecosystem processes and impairment of ecosystem services. Nowadays, climate change and introduction of non-native species are recognised as one of the main factors of freshwater biodiversity loss. Therefore, objective of this project is to study their influence onto freshwater organisms. In the focus of the proposed project are three freshwater native species (stone and noble crayfish, brown trout) that have key role in the ecosystems; crayfish ensuring their normal functioning and trout being economically important.  Their disappearance from a habitat significantly alters freshwater ecosystem processes, species abundance and diversity. These three species are highly sensitive to habitat alteration, and due to negative human impacts onto their habitats and pronounced climate changes, they are vulnerable and protected by international and national legislation. The purpose of proposed project is to study genetic variability of different populations of these three species using mitochondrial, nuclear and microsatellite DNA markers, aiming to bring new insight into their evolutionary history and to identify their evolutionary significant and management units. Further, the aim is to develop habitat suitability models for non-native invasive crayfish species and allochthones trout lineages that would enable us to foresee areas that will be under biggest pressure in the future. Also, the aim is to develop habitat suitability models for native species future distribution under climate change scenarios that will enable us to identify areas, which will be unsuitable for their survival as well as areas that will ensure their long-term survival. We expect that obtained results will serve as a sound base for development of conservation strategies and management plans for these three vulnerable freshwater species.]]></summary_en></project><project>
<id>7372</id><title_hr><![CDATA[Višestruki stresori u vodenom okolišu: razumijevanje svojstava stresora i receptora]]></title_hr><title_en><![CDATA[Understanding stressor and receptor properties in multi-stressed aquatic environments]]></title_en><user_id>12890</user_id><user_firstLast_name>Marko Rožman</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-2298</code><acronim><![CDATA[UNDERSTANDOR]]></acronim><duration>07.01.2019 - 06.01.2023</duration><status>Završio</status><financ_value>132.718,83 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Interdisciplinarne prirodne znanosti, Kemija, Biologija, </scie_field_hr><scie_field_en>Interdisciplinary natural sciences, Chemistry, Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>1414, 3926, 19938, 23444, 20412, 23729, 1522, 29033, 27426, </team_members_id><team_members_names><![CDATA[Sandra Babić, Mirta Čizmić, Igor Novak, Ivančica Ternjej, Ana Previšić, Vicenç Acuna, Zrinka Karačić, Katarina Cetinić, Ivana Grgić, ]]></team_members_names><keywords_hr><![CDATA[stresori, vodeni okoliš, onečišćivač, spektrometrija masa, nanomaterijali, metabolomika, proteomika]]></keywords_hr><keywords_en><![CDATA[multiple stressors, aquatic environment, emerging contaminants, mass spectrometry, nanomaterials, metabolomics, proteomics]]></keywords_en><summary_hr><![CDATA[Posljednja znanstvena dostignuća prepoznaju sve veći utjecaj kombinacije različitih stresora na vodna tijela u Europi. Razumijevanje međudjelovanja stresora i njihovog utjecaja na biološki te kemijski status vodenih ekosustava jedan je od glavnih izazova u oblikovanju budućih politika za zaštitu okoliša. Kako bi odgovorili na navedeni izazov, utjecaje stresora treba sagledati jednako iz perspektive stresora i receptora. Sukladno tome, svrha ovog projekta je doprinijeti razumijevanju svojstava stresora i receptora. Iz „perspektive stresora“, primjenjujući metode računalne kemije kao i multifaktorska fotodegradacijska istraživanja, projekt će unaprijediti razumijevanje međuodnosa onečišćivača u smjesi stavljajući poseban naglasak na nanomaterijale i njihovu interakciju s drugim onečišćivačima tijekom procesa adsorpcije i fotodegradacije. Iz „perspektive receptora“ projekt je usmjeren na pružanje zbirnog pogleda na molekularne procese tijekom općeg odgovora na višestruki stres. UNDERSTANDOR predlaže korištenje Postrojenja umjetnih rijeka (jedinstvenog sustava u Europi) i mesokosmos pokusa koji će omogućiti vremensko &#39;&#39;omics&#39;&#39; profiliranje biofilma kao i vodenih beskralješnjaka tijekom izlaganja ekološki značajnim (dugoročna izloženost niskim dozama) stresnim događajima. Dobiveni profili omogućit će vremensku rekonstrukciju dinamike gena, proteina i metabolita u zajednici biofilma i vodenih beskralješnjaka u uvjetima višestrukog stresa (npr. onečišćivači, temperatura, suša). Okupljanjem interdisciplinarnog tima s četiri europske i jedne ne-europske znanstvene institucije s jedinstvenom kombinacijom znanja i vještina, stvoriti će se razina znanja i iskustva neophodna za provođenje projektnih aktivnosti. Očekujemo da će rezultati istraživanja u okviru ovog projekta imati znatan utjecaj na područje istraživanja slatkih voda.]]></summary_hr><summary_en><![CDATA[Current state-of-the-art research identifies Europe’s water bodies and resources influenced by a complex mixture of stressors. Understanding how stressors interfere and impact biological and chemical status of aquatic system is identified as main challenge for shaping future environmental policies. To meet the challenge multiple stressors effects should be understood equally from stressor and receptor side. Accordingly, UNDERSTANDOR aims at advancing our knowledge on stressor and receptor properties in multi-stressed aquatic environments. In particular, on “stressor’s side” the project will further develop and apply some of the cutting edge computational chemistry methods and multifactorial photodegradation studies to improve our understanding of ensemble interactions of emerging contaminants (ECs). Special emphasis will be put on carbon based nanomaterials and their interactions with other xenobiotics during adsorption and photodegradation. From a “receptor’s side” the project will provide a multidisciplinary perspective of molecular responses and mechanisms resulting from multiple stress events (e.g. ECs, temperature, drought). The project proposes use of Experimental Stream Facility (a unique European facility) and mesocosm experiments that will permit temporal “omics” profiling of biofilm community and aquatic macroinvertebrates at environmentally relevant (long-term low-dose) multiple stress events. Obtained profiles will enable reconstruction of time points in gene-protein-metabolite dynamics of biofilm and macroinvertebrates under stress conditions. By assembling a multidisciplinary team of four European and one non-European scientific institution with unique combination of skills and expertise, a critical mass of experience and knowledge will be mobilized to carry out the project activities. Accordingly, we expect that the results produced by this innovative research plan will have substantial impact on the field of inland water research.]]></summary_en></project><project>
<id>7374</id><title_hr><![CDATA[Karakterizacija kandidat gena za kongenitalne anomalije bubrega i urotrakta (CAKUT) tijekom razvoja u miša i čovjeka]]></title_hr><title_en><![CDATA[]]></title_en><user_id>12479</user_id><user_firstLast_name>Katarina Vukojević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-3987</code><acronim><![CDATA[CAKUT]]></acronim><duration>10.01.2019 - 09.10.2024</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Split School of Medicine]]></institution_en><team_members_id>25216</team_members_id><team_members_names><![CDATA[ Doktorand: Anita Muić ]]></team_members_names><keywords_hr><![CDATA[kongenitalne anomalije bubrega i urotrakta, genetika, imunohistokemija, imunofluorescencija, knock-out miš]]></keywords_hr><keywords_en><![CDATA[congenital anomalies of the kidney and urinary tract, genetics, immunohistochemistry, immunofluorescence, knock-out mice]]></keywords_en><summary_hr><![CDATA[Kongenitalne anomalije bubrega i mokraćnog sustava (CAKUT) u 40-50% pedijatrijskih bolesnika dovode do krajnjeg stadija zatajenja bubrega. Među kategorijama CAKUTa, kongenitalna opstruktivna uropatija predstavlja zajednički i teški oblik malformacija. Zbog nedostatka temeljnog uvida o njegovoj primarnoj patogenezi, dijagnostičke i terapijske mogućnosti su ograničene.Nedavno smo identificirali dominantne štetne mutacije u DSTYK genu koji kodira dvostruku serin-treonin i tirozin protein-kinazu, kod osoba s malformacijama mokraćnog sustava koristeći sekvenciranje exoma u kombinaciji s funkcionalnim modelom u zebraste ribice (New Engl J Med 2013). Protein kodiran DSTYK genom djeluje kao pozitivan regulator u signalizaciji faktora rasta fibroblasta (FGF), tijekom nefrogeneze. Osim toga, identificirali smo pet novih gena kandidata za CAKUT koji su pokazali ekspresiju u miša i čovjeka tijekom razvoja urinarnog trakta. Među tim genima, DLG1 i KIF12 su vjerojatno susceptibilni geni za razvoj CAKUTa kod ljudi (Kidney Int 2015).Ovdje predlažemo početnu karakterizaciju funkcije novih gena kandidata za CAKUT tijekom embrionalnog razvoja, nefrogeneze i razvoja uretera. Prvo ćemo istraživati profil vremenskog-prostornog izražaja i ko-lokaliziranje kandidat gena za CAKUT u različitim fazama embriogeneze u tkivima normalnih miševa i ljudskog zametka te bubrega i mokraćnog sustava u razvoju i usporediti markere nefrogeneze i razvoja uretera. Zatim ćemo odabrati jedan visoko prioritetni novi kandidat gen te generirati i okarakterizirati miša koji nosi mutaciju u ovom genu od interesa (knockout miš), zatim ćemo identificirati mehanizme kojima mutacije u ovom genu dovode do malformacija urinarnog trakta kod ljudi.Ova studija je osmišljena kako bi se okarakterizirali funkcionalni učinci kandidat gena za CAKUT u razvoju mokraćnih puteva, identificirati disregulacijske putove i na kraju osmisliti nove dijagnostičke alate i terapijske strategije za taj učestali oblik zatajenja bubrega.]]></summary_hr><summary_en><![CDATA[Congenital Anomalies of the Kidney and the Urinary Tract (CAKUT) account for 40-50% of pediatric end-stage kidney failure. Among CAKUT categories, congenital obstructive uropathy represents a common and severe form. Due to paucity of fundamental insight about its primary pathogenesis, diagnostic and therapeutic options are severely limited.  We recently identified dominant deleterious mutations in DSTYK, encoding a dual serine-threonine and tyrosine protein-kinase, in individuals with urinary tract malformations using exome sequencing combined to functional modeling in zebrafish (New Engl J Med 2013). The protein encoded by DSTYK acts as a positive regulator of fibroblast growth factor (FGF) signaling during nephrogenesis. Additionally, we identified five novel candidate genes for CAKUT that showed specific expression in the human and mouse developing urinary tract. Among these genes, DLG1 and KIF12 are likely novel susceptibility genes for CAKUT in humans (Kidney Int 2015).Here we propose to initially characterize the function of novel CAKUT candidate genes during embryonic development, nephrogenesis and ureteric development. We will first study the candidate genes temporal-spatial expression and colocalization profile during different stages of embryogenesis in normal mouse and human embryonic tissue and in developing kidneys and urinary tract and compare to markers of nephrogenesis and ureteric development. We will next choose one high-priority novel candidate gene and generate and characterize mouse harboring mutation in a gene of interest (knockout mice) to identify the mechanisms by which mutations in this gene lead to urinary tract malformations in humans. This study is designed to characterize the functional effect of CAKUT candidate genes in urinary tract development, to identify dysregulated pathways, and, ultimately, to devise novel diagnostic tool and therapeutic strategies for this common form of renal failure.]]></summary_en></project><project>
<id>7387</id><title_hr><![CDATA[Unitarne reprezentacije, automorfne i modularne forme]]></title_hr><title_en><![CDATA[Unitary representations, automorphic and modular forms]]></title_en><user_id>1079</user_id><user_firstLast_name>Marcela Hanzer</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-3628</code><acronim><![CDATA[UNAM]]></acronim><duration>09.10.2018 - 08.10.2022</duration><status>Završio</status><financ_value>120.047,78 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>23430, 23409, 863, 1000, 890, 850, 820, 1154, 17779, </team_members_id><team_members_names><![CDATA[Petar Bakić, Barbara Bošnjak, Darija Brajković, Igor Ciganović, Neven Grbac, Ivan Matić, Goran Muić, Marko Tadić, Sonja Žunar, ]]></team_members_names><keywords_hr><![CDATA[unitarne reprezentacije, automorfne forme, modularne forme, klasične grupe, metaplektička grupa]]></keywords_hr><keywords_en><![CDATA[unitary representations, automorphic forms, modular forms, classical groups, metaplectic group]]></keywords_en><summary_hr><![CDATA[U projektu Unitarne reprezentacije, automorfne i modularne forme uključujemo se u novi val istraživanja u okviru Langlandsovog programa, omogućen, prije svega, novim rezultatima Arthura i suradnika. Istražujemo dvije teme koje se međusobno isprepliću: unitarne reprezentacije reduktivnih (i srodnih) p-adskih grupa, te klasične modularne i automorfne forme. U istraživanju unitarnog duala klasičnih grupa, među ostalim i koristeći rezultate Moeglin o konstrukciji A-paketa, namjeravamo konstruirati široke familije reprezentacija analiziranjem parabolički induciranih reprezentacija specijalnog tipa i odrediti kompozicione nizove. Time ćemo generalizirati mnoge rezultate Speh, Tadića, Muića, Matića i Hanzer. Automorfne reprezentacije globalnih klasičnih grupa namjeravamo analizirati prije svega koristeći Eisensteinove redove, proučavane u radovima Hanzer i Muića, te nedavne Arthurove rezultate o endoskopiji. Iz tih rezultata namjeravamo dobiti rezultate o L-funkcijama, a u dobivanju informacija o slikama Eisensteinovih redova namjeravamo koristiti rezultate dobivene iz lokalne teorije. S druge strane, ti se rezultati mogu primijeniti i na proučavanje klasičnih modularnih formi, uz pažljivo konstruiranje restrikcija. Modularne forme namjeravamo i direktno istražiti koristeći Poincareove redove, istražujući uvjete neponištavanja generalizirajući Muićeve rezultate i nalazeći baze pojedinih prostora modularnih formi. U analiziranju reprezentacija metaplektičke grupe namjeravamo proučavati generičke reprezentacije, i to koristeći nedavne rezultate Savina, Takede, Lapida, Atobe i Gana o konstrukciji lokalnih faktora i o theta korespondenciji.]]></summary_hr><summary_en><![CDATA[In project Unitary representations, automorphic and modular forms we are joining a new wave of research in the framework of Langlands program which stems from the recent results of Arthur and collaborators. We explore two intertwining themes: unitary representations of reductive p-adic (and related) groups and classical modular and automorphic forms. In the research of the unitary dual of classical groups, using, among other things, Moeglin’s results about construction of A-packets, we intend to construct large families of unitary representations. We plan to do that by analyzing parabolically induced representations of a special type and determine the composition series. By doing this, we generalize many results of Speh, Tadić, Muić, Matić and Hanzer. We intend to analyze automorphic representations of global classical groups primarily using Eisenstein series, in a way that was previously used in the works of Muić and Hanzer, and some recent results of Arthur about endoscopy. From these results, we intend to get information about L-functions, and in getting those knowledge, we intend to use results obtained in our research in local theory. On the other hand, the results on the Eisenstein series can be applied on the classical modular forms. We also intend to obtain new modular forms and analyze them using Poincare series, examining non-vanishing conditions and thus generalizing previous work of Muić. Also we want to find explicit bases for the spaces of modular forms. In the research of the representations of metaplectic group, we mostly intend to focus on generic representations, and we intend to use recent results of Savin, Takeda, Lapid, Atobe and Gan about construction of local factors and  theta correspondence.]]></summary_en></project><project>
<id>7405</id><title_hr><![CDATA[Enzimska sinteza fluoriranih kiralnih građevnih blokova]]></title_hr><title_en><![CDATA[Enzymatic Synthesis of Fluorinated Chiral Building Blocks]]></title_en><user_id>19060</user_id><user_firstLast_name>Maja Majerić Elenkov</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-4493</code><acronim><![CDATA[EnzyFluor]]></acronim><duration>01.10.2018 - 30.09.2022</duration><status>Završio</status><financ_value>112.814,39 eur</financ_value><scie_area_hr>Prirodne znanosti, Biotehničke znanosti, Biomedicina i zdravstvo, </scie_area_hr><scie_area_en>Natural sciences, Biotechnical sciences, Biomedicine and health sciences, </scie_area_en><scie_field_hr>Kemija, Biologija, Biotehnologija, </scie_field_hr><scie_field_en>Chemistry, Biology, Biotechnology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>352, 2835, 3232, 363, 28627, 858379, </team_members_id><team_members_names><![CDATA[Zvjezdana Findrik Blažević, Višnja Stepanić, Irena Dokli, Martina Sudar, Nevena Milčić, Petra Marin, ]]></team_members_names><keywords_hr><![CDATA[biokataliza, halogenhidrin-dehalogenaze, fluorirani kiralni građevni blokovi, kinetički model, molekulsko modeliranje]]></keywords_hr><keywords_en><![CDATA[biocatalysis, halohydrin dehalogenases, fluorinated building blocks, kinetical model, in sillico]]></keywords_en><summary_hr><![CDATA[Predloženi projekt usmjeren je na dizajn enzimskih transformacija kojima se polazeći iz epoksida, mogu pripraviti sintetski korisni fluorirani građevni blokovi. Halogenhidrin-dehalogenaze (HHDH), relativno nova i još uvijek nedovoljno istražena grupa enzima, koristit će se kao biokatalizatori. Fokus istraživanja će biti na procjeni utjecaja organskih otapala kao medija za provođenje ovih biotransformacija. Upotreba organskih otapala može imati prednosti u slučaju HHDH-kataliziranih reakcija. Prvenstveno se to odnosi na povećanje topljivosti i stabilnosti supstrata, što rezultira većim prinosom produkata. Ciljane transformacije su reakcije otvaranja fluoriranih derivata aril epoksida u prisutnosti natrij azida i natrij cijanida kao nukleofila. U reakcijama će se ispitati niz divljih tipova te genetski optimiziranih enzima radi odabira biokatalizatora s najboljim katalitičkim svojstvima. Korištenjem molekulskog uklapanja i metoda QM/MM odredit će se važni sterički i elektronski faktori koji utječu na katalitičku aktivnost, enantio- i/ili regioselektivnost reakcija.  Metode molekulske dinamike koristit će se i za ispitivanje utjecaja organskog otapala na strukturu, dinamiku i katalitičku aktivnost enzima. Nadalje, ispitat će se različita organska otapala u smjesi s vodom (monofazni i dvofazni sustavi) ili čista kao medij za provođenje enzimskih reakcija. Na odabranim sustavima odredit će se kinetike enzimskih reakcija, te utvrditi operacijska stabilnost enzima. Razvijeni kinetički modeli procesa će se koristiti za njihovu optimizaciju, tj. pronalaženje optimalnih radnih uvjeta kako bi se postigla maksimalna konverzija supstrata, enantiomerna čistoća produkta i/ili volumna produktivnost procesa, kao i za odabir najpovoljnijeg tipa reaktora za provedbu procesa te za uvećanje procesa. ]]></summary_hr><summary_en><![CDATA[The proposed project aims at the design of enzymatic conversions for the production of synthetically useful fluorinated chiral building blocks from epoxides. Halohydrin dehalogenases (HHDH), relatively new and still not sufficiently explored group of enzymes, will be used as biocatalysts. The strong focus will be on the evaluation of aqueous-organic solvent mixtures and pure organic solvents as reaction media. The use of organic media can offer significant advantages in the case of HHDH-catalysed transformations. In particular, it could lead to higher productivity, due to better solubility and stability of substrates. The target conversions are incorporation of cyano and azido groups through the HHDH-catalysed ring-opening reaction of fluorine-substituted aryl epoxides. The approach will be to select enzymes by screening a number of known wild-type and mutant enzymes. After the appropriate enzyme(s) and substrate(s) are selected, different organic solvents will be tested as media for the reaction, either as water-organic solvent mixtures or pure organic solvents. The important steric and electronic factors governing the catalytic activity, enantio- and / or regio-selectivity will be determined by using the molecular docking and QM/MM calculations in combination with the in silico mutagenesis study. The MD simulation in non-aqueous medium will be used for investigating the solvent effects on the structural and dynamic properties of HHDHs as well as their catalytic activity.  Furthermore, enzyme(s) will be kinetically characterized in the selected reaction media and its operational stability will be evaluated. Kinetical model of the process will be developed in order to facilitate the reaction optimization. With the use of the kinetic model it is possible to determine the best reactor type for the investigated reaction, and to find initial conditions to achieve high productivity, substrate conversion and product yield without extensive experimental work.]]></summary_en></project><project>
<id>7406</id><title_hr><![CDATA[Eksperimentalna i klinička istraživanja hipoksijsko-ishemijskog oštećenja mozga u perinatalnoj i odrasloj dobi, ZCI – Neuro, KK.01.1.1.01.0007]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6256</user_id><user_firstLast_name>Nataša Jovanov Milošević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-3771</code><acronim><![CDATA[]]></acronim><duration>03.10.2018 - 30.11.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>25418</team_members_id><team_members_names><![CDATA[ Doktorand: Sara Trnski ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>7408</id><title_hr><![CDATA[Cikloadicijske strategije prema policikličkim gvanidinima]]></title_hr><title_en><![CDATA[Cycloaddition strategies towards polycyclic guanidines]]></title_en><user_id>243</user_id><user_firstLast_name>Davor Margetić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-3298</code><acronim><![CDATA[CycloGu]]></acronim><duration>01.11.2018 - 31.10.2022</duration><status>Završio</status><financ_value>128.741,12 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>368, 566, 4851, 3939, 25478, 28639, 856211, </team_members_id><team_members_names><![CDATA[Zoran Glasovac, Ivana Antol, Anamarija Briš, Vjekoslav Štrukil, Akmaral Kussayeva, Luka Barešić, Petar Štrbac, ]]></team_members_names><keywords_hr><![CDATA[organska sinteza, cikloadicije, gvanidini, bazičnost, kvantno-kemijski računi]]></keywords_hr><keywords_en><![CDATA[organic synthesis, cycloadditions, guanidines, basicity, quantum-chemical calculations]]></keywords_en><summary_hr><![CDATA[Znanstveni pristup projekta temelji se na kombinaciji eksperimentalnih i teorijskih istraživanja. Projekt obuhvaća organsku kemijsku sintezu, fizikalno-kemijsku karakterizaciju novih organskih molekula, kao i kvantno-kemijske proračune i molekularno modeliranje.Cilj projekta je istražiti inherentna fizikalno-kemijska svojstva (poli)cikličnih gvanidina u kojima je barem jedan atom dušika ugrađen u heterociklički prsten ili vezan za policikličke strukture. Ciljevi su: a) Sinteza (poli)cikličkih molekularnih sustava koji posjeduju gvanidinske funkcionalnosti primjenom ekološki prihvatljivih sintetskih metoda (s naglaskom na cikloadicijske rakcije) i njihovu spektroskopsku i strukturnu karakterizaciju; b) Mehanističke studije primijenjenih reakcija; c) Detaljni uvid u temeljne molekularne mehanizme kako inkorporiranje gvanidinske funkcionalnosti u cikličke strukture posreduje svojstvu superbazičnosti; d) Razvoj modelnih cikličkih gvanidinskih sustava za anionsko prepoznavanje; e) Uporaba cikličkih gvanidinskih sustava u razvoju bazne katalize.Rezultati temeljnih studija provedenih u okviru ovog projekta poboljšat će razumijevanje fizikalno-kemijskih čimbenika koji upravljaju superbazičnosti u cikličkim sustavima i unaprijediti njihov dizajn. Očekivani rezultati omogućuju dizajn i pripravu novih cikličkih gvanidinskih sustava koji bi se mogli primijeniti u različitim istraživačkim područjima, uključujući anionsko prepoznavanje i homogenu katalizu, sintezu prirodnih produkata i bioaktivnih molekula.]]></summary_hr><summary_en><![CDATA[The scientific approach of the project is based on a combination of experimental and theoretical investigations. Project encompasses organic chemical synthesis, physico-chemical characterization of novel organic molecules, as well as quantum-chemical calculations and molecular modelling.The goal of the project is to investigate inherent physico-chemical properties of (poly)cyclic guanidines in which at least one nitrogen atom is embedded in heterocycle or attached to polycyclic structures. The objectives are: a) Synthesis of (poly)cyclic molecular systems possessing guanidine functionalities by employment of environmentally friendly synthetic methods (with the emphasize on cycloaddition reactions) and their spectroscopic and structural characterization; b) Mechanistic studies of reactions employed; c) Detailed insight into the fundamental molecular mechanisms how incorporation of guanidine moiety in cyclic structures mediates superbasicity properties; d) Development of model cyclic guanidine systems for anion sensing; e) Utilization of cyclic guanidine systems in development of base catalysis.The results of fundamental studies carried out within this project will enhance the understanding of physico-chemical factors governing superbasicity in cyclic systems and advance their design. Expected results will enable design and preparation of novel cyclic guanidine systems which could be applied in different research areas including anion sensing and homogeneous catalysis, synthesis of natural products and bioactive molecules.]]></summary_en></project><project>
<id>7419</id><title_hr><![CDATA[EVOLUCIJSKA SINTEZA OBLIKA S INTEGRALNIM I PARTICIONIRANIM 3D FENOTIPOVIMA, DINAMIČKOM PARAMETRIZACIJOM I BEZMREŽNIM MODELIRANJEM]]></title_hr><title_en><![CDATA[EVOLUTIONARY SHAPE SYNTHESIS WITH INTEGRAL AND PARTITINED 3D PHENOTYPES, DYNAMIC PARAMETERIZATIONS AND MESHLESS MODELING ]]></title_en><user_id>3851</user_id><user_firstLast_name>Damir Vučina</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-6774</code><acronim><![CDATA[Synth3D]]></acronim><duration>01.12.2018 - 30.11.2022</duration><status>Završio</status><financ_value>108.845,98 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Temeljne tehničke znanosti, Računarstvo, Strojarstvo, Interdisciplinarne tehničke znanosti, </scie_field_hr><scie_field_en>Basic engineering sciences, Computer sciences, Mechnical engineering, Interdisciplinary technological sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Fakultet elektrotehnike, strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Electrical Engineering, Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>23786, 13265, 13396, 4873, 4969, 4871, 5150, 4983, 21278, </team_members_id><team_members_names><![CDATA[Miro Bugarin, Ivo Marinić-Kragić, Milan Ćurković, Damir Sedlar, Igor Pehnec, Ivan Tomac, Željan Lozina, Zoran Milas, Anđela Bartulović, ]]></team_members_names><keywords_hr><![CDATA[Sinteza oblika, Evolucijska optimizacija, Učinkovita parametrizacija, Heterogeni fenotipovi, Particioniranje, Izogeometrijsko modeliranje]]></keywords_hr><keywords_en><![CDATA[Shape synthesis, Evolutionary optimization, Efficient parameterization, Heterogeneous phenotypes, Partitioning, Isogeometric modelling]]></keywords_en><summary_hr><![CDATA[Projekt nastavlja prethodni dvogodišnji HRZZ projekt koji je rezultirao u šest publikacija u prestižnim časopisima te planira razvoj generičke platforme za optimizacijski baziranu sintezu 3D oblika temeljenu isključivo na danim kriterijima izvrsnosti i ograničenjima, uključujući:- fazu apstraktne inicijalizacije (geneza 3D oblika) s uklanjanjem pristranosti prema bilo kojem obliku ili pojedinim sastavima geometrijskih primitiva- nasljeđivanje i uključivanje oblika postojećih objekata temeljenih na 3D skeniranju u oblake 3D točaka- evolucijsku optimizaciju oblika populacija heterogenih fenotipova pretvorenih u zajedničke genotipove na temelju parametarskog fitanja- dinamičku parametrizaciju koja obuhvaća čak i dramatično promjenjive 3D oblike temeljenu na inteligentnoj prilagodbi postojećim geometrijskim značajkama- 3D oblike konceptualno modelirane i kao integralne entitete i kao skupove particija s kodiranim međusobnim relacijama- razvoj opcija za detekciju značajki (npr. rubovi, vrhovi) u integralnim geometrijama za dekompoziciju optimiranog oblika,- konceptualni razvoj procesa post-optimizacije oblika integralnih oblika u smislu potencijalnog predstavljanja kao skupa djelomičnih particija oblika,- implementaciju izogeometrijske analize (IGA) u fazama analize polja za ograničenja i ciljne funkcije (izogeometrijske i bezmrežne metode bi mogle učinkovito podržati optimizaciju oblika uz istu infrastrukturu za analizu polja sa ograničenjima i za promjene oblika)- primjenu IGA u strategijama optimizacije uz iste baze uključene u parametrizaciju oblika i tražene izračune polja, što smanjuje utrošak vremena u prijenosu podataka.Projekt će razviti računalne radne tokove koji efikasno implementiraju gornje elemente te ih sustavno testirati. Proučit će se nekoliko teorijskih i stvarnih testnih slučajeva, a ad-hoc aerodinamički tunel će biti nadograđen za komparativnu eksperimentalnu verifikaciju optimiziranih oblika vjetroturbina s vertikalnom osi.]]></summary_hr><summary_en><![CDATA[The project continues the former two-year CSF project which resulted in six publications in prestigious journals and aims at developing a generic platform for optimization-based synthesis of 3D shape based solely on given excellence criteria and constraints, involving: - an abstract initiation phase (3D shape genesis) with elimination of bias towards any candidate shapes or particular compositions of geometric primitives- inheriting and import of shapes of existing objects based on 3D scanning into point clouds,- evolutionary shape optimization of populations of heterogeneous phenotypes converted into common genotypes based on parametric fitting- dynamic parameterization to encapsulate even dramatically changing 3D shapes based on intelligent adaptation to current shape features- 3D shapes conceptually modelled both as integral entities and sets of partitions with coding of mutual relationships- options for feature-detection approaches (e.g. edges, peaks) in integral geometries towards shape decomposition of optimized shape- conceptual development of post-shape-optimization processing of integral shapes in terms of potential representation as sets of partial shape entities,- implementation of isogeometric analysis (IGA) in the field analysis stages towards constraints and objective functions (isogeometric and meshless procedures could efficiently support shape optimisation using the same infrastructure in constraint dependent field analysis and reshaping)- application of IGA in optimisation strategies with the same basis involved in shape parameterization and field calculations, thereby reducing time consumption in data transfers.The project will develop computational workflows which efficiently implement above elements and systematically test them. Several theoretical and actual test-cases will be studied, and the ad-hoc aerodynamic tunnel will be upgraded for comparative experimental verification of optimized shapes of vertical-axis wind turbines.]]></summary_en></project><project>
<id>7422</id><title_hr><![CDATA[Rasvijetljavanje mehanizama rezistencije na terapiju raka debelog crijeva sa mutacijom BRAF pomoću integriranog -omics pristupa]]></title_hr><title_en><![CDATA[Dissecting the mechanisms of therapy resistance in BRAF-mutant colon cancer using an integrated –omics approach]]></title_en><user_id>3261</user_id><user_firstLast_name>Mirela Sedić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-3900</code><acronim><![CDATA[BRAFCON]]></acronim><duration>15.01.2019 - 14.01.2023</duration><status>Završio</status><financ_value>131.568,12 eur</financ_value><scie_area_hr>Prirodne znanosti, Biomedicina i zdravstvo, Interdiciplinarne znanosti, </scie_area_hr><scie_area_en>Natural sciences, Biomedicine and health sciences, Interdisciplinary scientific area, </scie_area_en><scie_field_hr>Interdisciplinarne prirodne znanosti, Biologija, Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Interdisciplinary natural sciences, Biology, Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Institut za antropologiju]]></institution_hr><institution_en><![CDATA[Institute for Anthropological Research]]></institution_en><team_members_id>19745, 23360, 7807, 12407, 19203, 28696, </team_members_id><team_members_names><![CDATA[Thomas Eichmann, Olga Vasieva, Djuro  Josic, Elitza Petkova Markova-Car, Petra Grbčić, Iris Car, ]]></team_members_names><keywords_hr><![CDATA[BRAF, rak debelog crijeva, kemorezistencija, proteomika, sfingolipidomika, sektretom stanica raka]]></keywords_hr><keywords_en><![CDATA[BRAF, colon cancer, chemoresistance, proteomics, sphingolipidomics, cancer secretome]]></keywords_en><summary_hr><![CDATA[Kolorektalni karcinom (CRC) je treće po redu najčešće dijagnosticirano maligno oboljenje i četvrti vodeći uzrok smrtnosti povezane s rakom na globalnoj razini. Zahvaljujući naprecima u sistemskoj kemoterapiji, ciljanim terapijama i kirurškim tehnikama, preživljenje pacijenata s metastatskim CRC se poboljšalo u posljednja dva desetljeća. Unatoč tome, napreci u terapiji nisu unaprijedili liječenje svih molekularnih podtipova CRC. Ovo se naročito odnosi na populaciju CRC pacijenata sa BRAFV600E mutacijom (7–10%) koji slabo odgovaraju na većinu sistemske terapije i imaju vrlo lošu prognozu. Vemurafenib, protein kinazni inhibitor BRAFV600E kojeg je FDA odobrila za liječenje metastatskog melanoma sa BRAFV600E mutacijom, unio je nadu u liječenje BRAF-mutiranog CRC. Međutim, suprotno rezultatima dobivenim kod melanoma sa BRAFV600E mutacijom, monoterapija vemurafenibom je pokazala limitiranu kliničku učinkovitost u CRC pacijenata sa BRAFV600E mutacijom. Kako bi se poboljšali ishodi liječenja CRC pacijenata sa BRAFV600E mutacijom, potrebno je bolje razumjeti mehanizme rezistencije na BRAF inhibitore. Projekt BRAFCON će rasvijetliti procese koji vode ka razvoju rezistencije na BRAF inhibiciju vemurafenibom u stanicama raka debelog crijeva sa BRAFV600E mutacijom tako što će omogućiti integraciju različitih slojeva molekularne informacije (proteom, glikoproteom, sekretom i sfingolipidom) uzevši u obzir složenu interakciju između molekularnih signala unutar i izvan stanica raka debelog crijeva koji utječu na brojne aspekte staničnog ponašanja. Bioinformatička analiza i integracija –omics podataka će otkriti nove markere i mete rezistencije omogućujući tako dizajniranje nove kombinirane strategije za prevladavanje terapijske rezistencije na vemurafenib koja će potom biti validirana in vitro. Na taj će način BRAFCON doprinjeti razvoju novih modaliteta liječenja oboljelih od raka debelog crijeva sa BRAF mutacijom. ]]></summary_hr><summary_en><![CDATA[Colorectal cancer (CRC) is the third most commonly diagnosed malignancy and the fourth leading cause of cancer-related deaths in the world. Owing to the improvements in systemic chemotherapy, targeted therapies and surgical techniques, the survival of patients with metastatic CRC (mCRC) has improved over the past two decades. Still, these therapeutic advances have not brought benefit to all molecular subtypes of CRC. This particularly holds true for the population of mCRC patients with BRAFV600E mutation (7–10%) which have poor response to most systemic therapies and a very poor prognosis. Vemurafenib, a protein kinase inhibitor of BRAFV600E approved by the FDA for the treatment of metastatic melanoma with BRAFV600E mutation, has raised hopes of treatment for BRAF-mutant CRC. However, opposite to the results seen in patients with BRAFV600E mutant melanoma, single-agent vemurafenib exerted limited clinical efficacy in patients with BRAFV600E mutant CRC. In order to improve outcomes in CRC patients with BRAF mutation, there is a critical need to better understand the mechanisms of resistance to BRAF inhibitors. The BRAFCON project strives to give a new perspective on the processes governing acquired resistance to BRAF inhibition by vemurafenib in BRAFV600E mutant colon cancer cells by integrating different layers of molecular information (proteome, glycoproteome, secretome and sphingolipidome) while taking into account an intricate interplay of molecular signals both, inside and outside of colon cancer cells that influence multiple aspects of cell behaviour.  Bioinformatics analysis and integration of –omics data would reveal novel resistance markers and targets guiding the design of new combinatorial strategy to counter therapeutic resistance to vemurafenib in BRAF-mutant colon cancer cells, which will be validated in vitro. In this way, BRAFCON will contribute to the development of new treatment modalities for BRAF-mutant colon cancer patients.  ]]></summary_en></project><project>
<id>7428</id><title_hr><![CDATA[Genotipska specifičnost pšenične trave (Triticum aestivum L.) visokonutritivnog prirodnog dodatka prehrani]]></title_hr><title_en><![CDATA[]]></title_en><user_id>22586</user_id><user_firstLast_name>Miroslav Lisjak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-1672</code><acronim><![CDATA[WHEAT4GRASS]]></acronim><duration>24.10.2018 - 31.12.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Fakultet agrobiotehničkih znanosti Osijek]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Agrobiotechnical Sciences in Osijek]]></institution_en><team_members_id>25321</team_members_id><team_members_names><![CDATA[ Doktorand: Marija Kristić ]]></team_members_names><keywords_hr><![CDATA[pšenična trava, in vitro bioraspoloživost, antioksidacijska aktivnost, obogaćeni proizvod, biofortifikacija, nutraceutik]]></keywords_hr><keywords_en><![CDATA[wheatgrass, in vitro bioavailability, antioxidative activity, enriched food, biofortification]]></keywords_en><summary_hr><![CDATA[Podizanjem svijesti o važnosti zdrave prehrane sve je veća potražnja za funkcionalnom hranom. Najjednostavniji oblik funkcionalne hrane su namirnice koje prirodno imaju visok sadržaj tvari s pozitivim utjecajem na zdravlje ljudi. Takva namirnica je pšenična trava (Triticum aestivum L.) koja se u obliku svježeg soka ili praha koristi kao dodatak prehrani. Pšenična trava predstavlja mlade izdanke vrsta roda Triticum koji u velikim količinama sadrže klorofil, bioflavonoide, esencijalne aminokiseline, vitamine, minerale i antioksidante. Zbog svog sastava pšenična trava ima značajan pozitivna utjecaj na detoksikaciju organizma, jačanje imuniteta i cijeli niz akutnih oboljenja. Ciljevi predloženog istraživanja su (1) ispitati genotipsku specifičnost pšenične trave s obzirom na in vitro bioraspoloživost Zn, Fe, Se, Mn, Mg, Ca, K i Na, antioksidacijsku aktivnost te sadržaj kloroplastnih pigmenata, (2) ispitati utjecaj biofortifikacije cinkom i selenom na mineralni sastav, antioksidacijsku aktivnost i sadržaj kloroplasta, (3) izdvojiti genotipove pšenice za uzgoj pšenične trave koji će se moći preporučiti za direktnu uporabu kao dodatak prehrani, (4) ispitati antiproliferativni učinak ekstrakata pšenične trave na humanim tumorskim staničnim linijama. Ispitivanje genotipske specifičnosti provest će sa na 100 genotipova pšenice različitog podrijetla te će se izabrati genotipovi na kojima će se ispitivati utjecaj biofortifikacije selenom i cinkom na ispitivana svojstva pšenične trave. Antiproliferativni učinak ekstrakata pšenične trave ispitat će se na 5 humanih tumorskih staničnih linija. Predloženo istraživanje rezultirat će saznanjima značajnima hrvatskoj i međunarodnoj znanstvenoj zajednici, jer istraživanje pšenične trave ovakvog tipa i ovakvog obima još nije provedeno. Prema našim saznanjima, prva smo istraživačka skupina u Republici Hrvatskoj koje će se baviti istraživanjima na pšeničnoj travi.]]></summary_hr><summary_en><![CDATA[Raising awareness on the importance of healthy diet has increase demand for functional food. In their simplest form, functional food is a food that naturally possess substances that positively affect people&#39;s health. Wheatgrass (Triticum aestivum L.) is such food. Wheatgrass can be utilized as a dietary supplement in the form of fresh juice or powder made from young shoots of species of the genus Triticum. It contains chlorophyll, bioflavonoids, essential amino acids, vitamins, minerals and antioxidants in high quantities. Because of its composition, wheatgrass has a significant positive effect on detoxification of the body, strengthening of immunity and on a full range of acute illnesses. In the proposed study we will investigate (1) the genotype specificity of wheatgrass regarding the in vitro bioavailability of Zn, Fe, Se, Mn, Mg, Ca, K and Na, antioxidant activity and chloroplast pigment content, 2) the influence of zinc and selenium biofortification on mineral composition, antioxidant activity and content of chloroplast pigments; (3) select wheatgrass genotypes for cultivation and for recommendation for usage in the form of powder or fresh juice, (4) the antiproliferative effect of wheatgrass extracts on human tumor cell lines. A genotype specificity will be tested on a set of 100 wheat genotypes of different origin. Based on the results of genotype specificity testing, 10 genotypes will be selected for investigation of the effect of zinc and selenium biofortification on examined traits in wheatgrass. Investigation of the antiproliferative effect of wheat grass extracts will be performed on 5 human tumor cell lines. The proposed research will result in findings that are significant to the Croatian and international scientific community. Research of this type and this scope on wheatgrass has not been carried out yet. According to our knowledge, we are the first research group in the Republic of Croatia that will research nutraceutical properties of wheatgrass.]]></summary_en></project><project>
<id>7429</id><title_hr><![CDATA[Pouzdani kompozitni primjenski sustavi zasnovani na web uslugama]]></title_hr><title_en><![CDATA[Reliable Composite Applications Based on Web Services]]></title_en><user_id>7793</user_id><user_firstLast_name>Siniša Srbljić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-6423</code><acronim><![CDATA[RELS]]></acronim><duration>01.12.2018 - 30.11.2022</duration><status>Završio</status><financ_value>119.408,59 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>12997, 12993, 11194, 22589, 27127, </team_members_id><team_members_names><![CDATA[Marin Šilić, Klemo Vladimir, Goran Delač, Adrian Satja Kurdija, Lucija Šikić, ]]></team_members_names><keywords_hr><![CDATA[kvaliteta usluge, predviđanje, web usluge, odabir usluga, kompozicija usluga]]></keywords_hr><keywords_en><![CDATA[QoS, Prediction, Web Services, Services Selection, Services Composition]]></keywords_en><summary_hr><![CDATA[U posljednjih nekoliko godina sveprisutne su postale različite platforme zasnovane na računarstvu u oblaku. Korištenje udaljenih usluga omogućava računalno rasterećenje te dobiva sve veći značaj s popularizacijom različitih komercijalnih sustava zasnovanih na konceptu Interneta stvari. Jedan od glavnih istraživačkih izazova u računarstvu zasnovanom na uslugama jest pouzdanost web usluga. Web usluge su primjenski sustavi postavljeni na Internetu koji svoje funkcionalnosti pružaju putem javno dostupnih i poznatih sučelja. Posljedica je da se kvalitetom usluge (QoS) ne može upravljati s aspekta korisnika obzirom da korisnik nema izravnu kontrolu nad trenutnim stanjem okoline unutar koje se usluga izvršava i nema uvid u različita nefunkcijska svojstva komunikacijskog kanala. Ovaj projekt fokusiran je na dvije osnovne teme u području pouzdanosti računarstva zasnovanog na uslugama. Prva tema pokriva područje predviđanja QoS parametara atomarnih web usluga. Predviđanje je popularna metoda procjene QoS parametara web usluga jer tradicionalni koncept mjerenja nije primjenjiv zbog degradacije radnih svojstava web usluge. Konkretno, aktivnosti u okviru prve teme fokusirane su na predviđanje QoS parametara uz poznavanje konteksta unutar kojeg se poziv odvija. Bolje poznavanje konteksta poziva web usluge omogućuje bolju procjenu QoS parametara. Druga tema istraživanja bavi se problemom odabira usluga prilikom izgradnje kompozitnih primjenskih sustava. Kompozitni primjenski sustavi izgrađeni su od atomarnih usluga gdje svaka usluga pruža određenu funkcionalnost. Međutim, u praksi često postoji više različitih instanci usluga koje pružaju željenu funkcionalnost. Tada se odabir pojedine instance u kompoziciji zasniva na analizi ostalih nefunkcijskih svojstava. U okviru projekta fokus će biti na oblikovanju učinkovitih i preciznih algoritama za odabir prikladnih instanci atomarnih usluga u trenutku izvršavanja kompozitnog primjenskog sustava.]]></summary_hr><summary_en><![CDATA[Recent years have brought a rapid adoption of platforms based on computing in the cloud. Consumption of remote services that enable computational offloading has gained traction as various systems based on the Internet of Things (IoT) concept are becoming increasingly popular. One of the main research concerns in service-oriented computing is the question of maintaining a reliable execution environment. Services are self-contained applications deployed on remote servers which can be consumed using well-established interfaces. Thus, the Quality of Service (QoS) cannot be maintained by the service consumer as it does not have the direct control over the execution environment nor does it have control over the parameters influencing the non-functional properties of the communication channel.This project focuses on two major problems in the area of dependable service computing. The first topic covers the issues of predicting the QoS parameters of atomic web services. Prediction is one of the popular methods to estimate the QoS parameters as active measurements can lead to degradation of service quality. More specifically, the project activates are focused on context-aware QoS prediction that gives estimation of QoS properties as seen by the service consumer. The other portion of research efforts of this project is focused at service selection. It is often the case that atomic services are used as building blocks to create more complex composite applications. In such cases, each atomic service has the purpose of handling a specific functional requirement of the application. However, multiple different web services that meet specific functional properties can be available. In such an environment it is possible to select a service with more favorable QoS properties during runtime. This project focuses on developing efficient and accurate algorithms that can perform atomic service selection at the time of service composition invocation.]]></summary_en></project><project>
<id>7434</id><title_hr><![CDATA[H2020-MSCA-RISE-2015: Advanced physical-acoustic and psycho-acoustic diagnostic methods for innovation in building acoustics (papabuild)]]></title_hr><title_en><![CDATA[]]></title_en><user_id>19019</user_id><user_firstLast_name>Marko Horvat</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-4147</code><acronim><![CDATA[]]></acronim><duration>22.10.2018 - 21.10.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>25352</team_members_id><team_members_names><![CDATA[ Doktorand: Dominik Kisić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>7435</id><title_hr><![CDATA[TFF3 protein na raskrižju metabolizma i neurodegeneracije]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1263</user_id><user_firstLast_name>Mirela Baus Loncar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-2572</code><acronim><![CDATA[Inter MeNe-3]]></acronim><duration>10.10.2018 - 09.12.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>25290</team_members_id><team_members_names><![CDATA[ Doktorand: Iva Bazina ]]></team_members_names><keywords_hr><![CDATA[Tff3 protein, jetra, mozak, diabetes, neurodegeneracija, Alzheimerova bolest homeostaza  glukoze, stres endoplazmatskog retikuluma  ]]></keywords_hr><keywords_en><![CDATA[Tff3 protein, liver, brain, diabesity, neurodegeneracija, Alzheimer disasese, glucose homeostasis, endoplasmatic reticulum (ER) stress  ]]></keywords_en><summary_hr><![CDATA[Većina bolesti koje prate užurbani životni ritam su povezane sa poremećenim metabolizmom glukoze i lipida. Diabetes i Alzheimerova bolest (AB) su među najvećim prijetnjama današnjice. Obje bolesti  u podlozi imaju neosjetljivost na inzulin i zajedničke upalne signalne putove. Kliničke i pred kliničke studije pokazale su  da je AB degenerativna metabolička bolest, posredovana narušenim inzulinskim signaliziranjem u mozgu, poremećenim iskorištenjem glukoze i energetskog metabolizma koji dovode do oksidativnog stresa, upale i pogoršanja inzulinske  neosjetljivosti. Veza između diabetes/debljine i AB, može razjasniti mehanizam nastanka sporadične AB koja se javlja kod 90% AB pacijenata. Potraga za biomarkerima u likvoru  AB pacijenata otkrila  je  TFF3 protein (Trefoil factor family protein 3) kao mogućeg povezujućeg kandidata. Nova istraživanja pokazala su da bolest nealkoholna masna jetra izazvana masnom hranom u mišjem modelu može uzrokovati sve simptome AB uključujući i smrt neurona. Dramatično smanjenje razine Tff3 glasničke RNA u jetri uočena je u ranoj fazi diabetesa kod mišjeg modela diabetes Tipa 2 (Tally Ho). Tff3 protein je prisutan u neuronima a Tff3 iz jetre može djelovati neuroprotektivno i nakupljati se u mozgu nakon ozljede. Cilj ovog projekta je utvrditi ulogu Tff3 proteina u Jetri/mozgu koristeći Tff3 -/- mišji soj i modelirajući diabetesa tipa 1 i tipa 2. Korelirati ćemo učinak nedostatka Tff3 na jetru kao glavni metabolički organ i mozak (hippocampus/cortex),te pratiti specifične pokazatelje neurodegeneracije i stresa endoplazmatskog retikuluma. Koristeći novu tehnologiju (XFe96 Extracellular Flux Analyzer) utvrdit ćemo učinak Tff3 na mitohondrijsku respiraciju i glikolizu u živućim primarnim hepatocitima. Ovakav sistemski pristup pridonijeti će razumijevanju zajedničkih procesa koji se odvijaju u osnovi obje bolesti (diabetesa i neurodegeneracije), te potencijalno ukazati na nove terapijske mete. ]]></summary_hr><summary_en><![CDATA[Most of the diseases accompanying fast  life rhythm in developed countries are connected with  deregulated  lipid and glucose metabolism. Diabetes and Alzheimer’s disease (AD) are considered among top threats to human health and they both have in common insulin resistance and common inflammatory signaling pathways. Human and preclinical studies have provided convincing evidence that AD is a degenerative metabolic disease, mediated by impaired insulin responsiveness in the brain, glucose utilization and energy metabolism leading to increased oxidative stress, inflammation and worsening of insulin resistance. The connection between diabetes/obesity and AD, may shed light how sporadic AD develops. Biomarker search in cerebrospinal fluid of  AD  patients  identified  TFF3 protein as a new  possible candidate for this crosstalk. Novel research showed that non-alcoholic fatty liver disease provoked by High fat diet is able to induce hallmarks of AD and even neuronal death in wild type mice. Diminishment of liver Tff3 gene expression was noticed in early stage of diabetes in Tally Ho mouse model of Type 2 diabetes. Tff3 protein is present in neurons and liver produced Tff3 can act neuroprotective and concentrate in brain upon injury. In this project  proposal we will investigate impact of Tff3 protein in liver/brain axis using  Tff3 -/- mouse strain and modeling Type 1 and Type 2 diabesity conditions. We will correlate  the effect  of Tff3 deficiency on liver as major metabolic organ,  and hippocampus/cortex as affected brain regions is AD, monitoring neurodegenerative hallmarks and endoplasmatic reticulum stress markers. Using novel technology (XFe96 Extracellular Flux Analyzer) we will estimate impact of Tff3 on mitochondrial respiration and glycolysis in living primary hepatocytes. This systemic approach will help us understand common pathways in diabesity and neurodegeneration and possibly reveal novel therapeutic targets. ]]></summary_en></project><project>
<id>7438</id><title_hr><![CDATA[Višegodišnje i dekadne oscilacije Jadranskog mora: opažanja, modeliranje  i posljedice]]></title_hr><title_en><![CDATA[]]></title_en><user_id>195</user_id><user_firstLast_name>Ivica Vilibić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-7511</code><acronim><![CDATA[ADIOS]]></acronim><duration>11.07.2018 - 30.11.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Geofizika, </scie_field_hr><scie_field_en>Geophysics, </scie_field_en><institution_hr><![CDATA[Institut za oceanografiju i ribarstvo]]></institution_hr><institution_en><![CDATA[Institute of Oceanography and Fisheries]]></institution_en><team_members_id>25204</team_members_id><team_members_names><![CDATA[ Doktorand: Petra Zemunik ]]></team_members_names><keywords_hr><![CDATA[Jadransko more, višegodišnje i dekadske oscilacije, stvaranje guste vode, BIOS, združeno klimatsko modeliranje atmosfere i mora]]></keywords_hr><keywords_en><![CDATA[Adriatic Sea, interannual and decadal oscillations, dense water formation, BIOS regimes, coupled atmosphere/ocean climate modelling]]></keywords_en><summary_hr><![CDATA[Glavni cilj projekta Adios je istražiti i kvantificirati procese koji pogone međugodišnje i desetljetne termohaline varijacije u jadransko-jonskom bazenu. Cilj će se postići (i) dokumentiranjem međugodišnje i desetljetne varijabilnosti analizom dugoročnih oceanografskih mjerenja i postojećih klimatskih modela, (ii) istraživanjem kratkoročnih i dugogodišnjih procesa koji pokreću jadransko-jonsku termohalinu cirkulaciju, u prvom redu stvaranje guste vode u Jadranu i BIOS-a (Bimodalna jadransko-jonska oscilacija), i (iii) procjenom prošle i buduće jadranske klime i varijabilnosti primjenom jadranskog združenog (atmosfera-more) klimatskog modela visoke razlučivosti. Iako se odavno zna da je međugodišnja i desetljetna termohalina promjenjivost dominantna u Jadranu, odgovarajuća teorija (BIOS) razvijena je tek nedavno, te još uvijek nije ispravno reproducirana od strane oceanskih numeričkih modela. Stoga će se u okviru ADIOS projekta postaviti i pokrenuti ugniježđeni združeni klimatski model visoke rezolucije u području Jadrana. Nakon verifikacije nad mjerenjima, model će se primijeniti na buduću klimu koristeći nekoliko IPCC scenarija. Takav pristup omogućit će preciznu procjenu budućih klimatskih promjena na Jadranu, uključujući i višegodišnju i desetljetnu varijabilnost i regulirajuće procese, što će biti temelj za procjenu klimatskih rizika na nacionalnoj i regionalnoj razini. Značajan projektni napor će se posvetiti nastavku mjerenja na Palagruškom oceanografskom profilu, najdužem sezonski uzorkovanom oceanografskom transektu na Sredozemlju u trajanju od oko 60 godina, ali vrlo rijetko uzorkovanom nakon 2013. godine. ADIOS projekt će imati snažnu međunarodnu komponentu koja uključuje priznate oceanografske institute (OGS, CNRS-GAME), te njihove istraživače aktivno uključene na predviđena projektna istraživanja, što će rezultirati povećanjem kapaciteta, umreženosti i učinkovitosti hrvatske oceanografske i klimatske zajednice.]]></summary_hr><summary_en><![CDATA[The major objective of the ADIOS project is to investigate and to quantify processes driving interannual to decadal thermohaline variations in the Adriatic-Ionian basin. This objective will be achieved by (i) documenting interannual to decadal variability from long-term oceanographic series and existing climate models, (ii) investigating short- and long-time processes that drive the Adriatic-Ionian thermohaline circulation, primarily the Adriatic dense water formation and the BiOS (Adriatic-Ionian Bimodal Oscillating System), and (iii) assessing past and future Adriatic climate and variability from the Adriatic-adopted high-resolution atmosphere/ocean climate model runs. Although interannual to decadal thermohaline variability is known to be dominant in the Adriatic, the respective theory (cf. BIOS) has been developed very recently and is still not properly reproduced and verified by ocean numerical models. To tackle this, the Adriatic climate run will be setup and executed through nesting of state-of-the-art high-resolution atmospheric/ocean models into the Mediterranean runs. Once validated for a 30 year hindcast time period, the Adriatic model will be used in forecast mode for several IPCC scenarios. Such an approach will allow for better assessment of future climate changes in the Adriatic, including interannual to decadal variability and governing processes. These simulations will be a base for an upgrade in climate hazard assessment on national and basin levels. A significant project effort will be dedicated to continuation of the Palagruža Sill oceanographic transect, the longest seasonally-sampled transect in the Mediterranean, lasting over 60 years but very sparsely sampled since 2013. The project will have a strong international component, incorporating recognized institutes (OGS, CNRS-GAME) and their researchers to the ADIOS research and therefore increasing capacities, networks and efficiency of the Croatian oceanographic and climate communities.]]></summary_en></project><project>
<id>7441</id><title_hr><![CDATA[Molekularni mehanizam neurodegeneracije u Niemann-Pickovoj bolesti tip C]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4828</user_id><user_firstLast_name>Silva Katušić Hećimović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-7587</code><acronim><![CDATA[neuroNiPiC]]></acronim><duration>09.10.2018 - 09.12.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>25281</team_members_id><team_members_names><![CDATA[ Doktorand: Ana Rastija ]]></team_members_names><keywords_hr><![CDATA[Alzheimerova bolest, Aß, APP, BACE1, kolesterol, neurodegeneracija, neuroinflamacija, Niemann-Pickova bolest tip C, NPC1, tau]]></keywords_hr><keywords_en><![CDATA[Alzheimer’s disease, Aß, APP, BACE1, cholesterol, neurodegeneration, neuroinflammation, Niemann-Pick type C disease, NPC1, tau]]></keywords_en><summary_hr><![CDATA[Niemann-Pickova bolest tip C (NPC) je rijetka dječja progresivna neurodegenerativna bolest koju karakterizira nakupljanje kolesterola, gubitak Purkinjeovih neurona u cerebelumu, hiperfosforilacija proteina tau i značajna neuroinflamacija. Intrigantno je da ova rijetka nasljedna bolest (uzrokovana mutacijama u genu NPC1 ili NPC2) pokazuje niz značajki kompleksne Alzheimerove bolesti (AB). Međutim, ove neurodegenerativne bolesti pokazuju različitu „ranjivost“ regija mozga; hipokampus je primarno oštećen u AB, dok je pošteđen u bolesti NPC, a cerebelum je pošteđen u AB, dok je primarno zahvaćen u bolesti NPC. U ovom projektu ćemo primijeniti saznanja opsežnih istraživanja proteolitičke razgradnje proteina prekursora peptida amiloid-ß (APP) u najčešćoj neurodegenerativnoj bolesti AB s ciljem razumijevanja molekularnog mehanizam neurodegeneracije u rijetkoj bolesti NPC. Potaknuti našim nedavnim otkrićem da jedan od glavnih enzima AB ß-sekretaza (BACE1) povećano cijepa protein APP u bolesti NPC, ispitat ćemo ulogu proteolize enzimom BACE1 u patogenezi bolesti NPC i može li BACE1 predstavljati novu ciljnu molekulu za tretiranje/ublažavanje bolesti NPC. U hipokampusu i cerebelumu NPC1- i wt-miševa ispitat ćemo proteolizu i distribuciju APP kao i dva nedavno otkrivena isključiva supstrata za BACE1. Primarne kulture neurona hipokampusa i Purkinjeovih neurona cerebeluma ćemo upotrijebiti za otkrivanje mehanizma učinka BACE1 na patološke značajke NPC bolesti. Također, razvit ćemo ex vivo model bolesti NPC korištenjem organotipskih kultura moždanih rezova hipokampusa i cerebeluma te ćemo pratiti utjecaj inhibicije BACE1 na prevenciju/ublažavanje patoloških značajki bolesti NPC. Konačno, generirat ćemo mišji model NPC1 u kojem ćemo ukloniti gen BACE1 za potvrdu dobivenih rezultata in vivo. Ova istraživanja će ukazati na ulogu BACE1 u patogenezi NPC bolesti i na potencijalno ciljanje enzima BACE1 kao alternativnog pristupa liječenja ove još uvijek neizlječive bolesti.]]></summary_hr><summary_en><![CDATA[Niemann-Pick type C disease (NPC) is a rare childhood progressive neurodegenerative disorder characterized by cholesterol accumulation, the loss of Purkinje neurons in the cerebellum, hyperphosphorylation of tau and profound neuroinflammation. It is intriguing that this rare inherited disease (caused by mutations in NPC1 or NPC2 genes) shows several key features of a complex Alzheimer&#39;s disease (AD). However, these two neurodegenerative disorders show different regional vulnerabilities; hippocampus is the most affected region in AD and is spared in NPC disease, and the cerebellum is spared in AD but is primarily affected in NPC. In this project we will use the knowledge gained through extensive research on the processing of the ß-amyloid precursor protein (APP) in the most common neurodegenerative disease AD to elucidate molecular mechanism(s) of neurodegeneration in a rare disorder NPC. Based on our recent finding that proteolysis of APP by one of the key AD enzymes ß-secretase (BACE1) is enhanced in NPC, in this project we will elucidate the role of BACE1 in the pathogenesis of NPC and whether BACE1 may represent a novel target for treating/ameliorating NPC disease. We will analyze BACE1-proteolysis and distribution of APP and the two recently identified exclusive BACE1 substrates in hippocampus and cerebellum of NPC1- and wt-mice. Primary hippocampal and cerebellar Purkinje neuronal cultures will be used to dissect the mechanism(s) of the BACE1-mediated effect on pathological features of NPC. Also, we will develop an ex vivo model of NPC disease using hippocampal and cerebellar organotypic brain slices and will monitor whether BACE1-inhibition may prevent/ameliorate any of the NPC pathological features. Lastly, we will genetically deplete BACE1 in NPC1-mice to validate our findings in vivo. These studies may indicate a role of BACE1 in NPC pathogenesis and the potential of targeting BACE1 as an alternative approach for treating this devastating disease.]]></summary_en></project><project>
<id>7442</id><title_hr><![CDATA[Mikotoksini u hrvatskim tradicionalnim mesnim proizvodima: molekularna identifikacija plijesni producenata i procjena izloženosti potrošača]]></title_hr><title_en><![CDATA[Mycotoxins in traditional Croatian meat products: molecular identification of mycotoxin-producing moulds and consumer exposure assessment ]]></title_en><user_id>135</user_id><user_firstLast_name>Jelka Pleadin</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-9017</code><acronim><![CDATA[TMPmouldRISK]]></acronim><duration>01.11.2018 - 31.10.2022</duration><status>Završio</status><financ_value>132.712,19 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Prehrambena tehnologija, Interdisciplinarne biotehničke znanosti, </scie_field_hr><scie_field_en>Food technology, Interdisciplinary biotechnical sciences, </scie_field_en><institution_hr><![CDATA[Hrvatski veterinarski institut]]></institution_hr><institution_en><![CDATA[Croatian Veterinary Institute]]></institution_en><team_members_id>7761, 19402, 23422, 23487, 2782, 4243, 3740, 23478, 3689, 23472, 23475, 23470, </team_members_id><team_members_names><![CDATA[Nada Vahčić, Željko  Jakopović, Tomaz Polak, Brigita Hengl, Mario Mitak, Manuela Zadravec, Nina Kudumija, Tina Lešić, Ana Vulić, Mario Škrivanko, Irena Perković, Maja Kiš, ]]></team_members_names><keywords_hr><![CDATA[mikotoksini, hrvatski tradicionalni mesni proizvodi, molekularna identifikacija, plijesni, procjena izloženosti potrošača]]></keywords_hr><keywords_en><![CDATA[mycotoxins, traditional Croatian meat products, molecular identification, moulds, consumer exposure assessment ]]></keywords_en><summary_hr><![CDATA[Dosadašnja istraživanja o mikotoksinima u tradicionalnim mesnim proizvodima (TMP) uglavnom su usmjerena na okratoksin A (OTA) te aflatoksin B1 (AFB1), dok su spoznaje o pojavnosti citrinina (CIT), sterigmatocistina (STC) i ciklopiazonične kiseline (CPA) općenito nedostatne. Isto tako, nedostaje podataka o vrstama plijesni koje obrastaju površinu TMP i produciraju ove mikotoksine kao sekundarne metabolite u ovisnosti o brojnim čimbenicima utjecaja. U okviru predloženog projekta, u najznačajnijih predstavnika hrvatskih TMP, molekularnim metodama (lančana reakcija polimerazom, PCR) identificirati će se vrste površinskih plijesni i dokazati geni odgovorni za produkciju mikotoksina. Identificirane plijesni dovesti će se u vezu s utvrđenim senzorskim i fizikalno-kemijskim svojstvima TMP te pojavnošću mikotoksina. Koncentracije AFB1, OTA i CIT odrediti će se primjenom tekućinske kromatografije (ultra) visoke djelotvornosti u kombinaciji s fluorescentnom detekcijom (uHPLC-FLD), dok će se za određivanje STC i CPA razviti metode tekućinske kromatografije s tandemskom spektrometrijom masa (LC-MS/MS). Razvoj ovih metoda dati će značajan analitički doprinos u daljnjim istraživanjima pojavnosti STC i CPA u mesnim proizvodima diljem svijeta. Prema našim saznanjima, provedena istraživanja po prvi puta će dati uvid u koncentracije svih mikotoksina značajnih za mesne proizvode, ujedno uzimajući u obzir utjecaj vrste TMP te regionalnih klimatskih uvjeta tijekom dvije proizvodne godine. Temeljem prehrambenih navika stanovništva u Hrvatskoj, provesti će se procjena izloženosti potrošača mikotoksinima kroz konzumaciju ove vrste proizvoda, a rezultati istraživanja služiti će za izradu znanstvenog mišljenja, kao vrijedne podloge nadležnim tijelima u području sigurnosti hrane za uspostavu najvećih dopuštenih količina (NDK) mikotoksina u mesnim proizvodima, te proizvođačima u cilju prevencije kontaminacije TMP.]]></summary_hr><summary_en><![CDATA[Research on mycotoxins in traditional meat products (TMPs) conducted insofar has mostly been focused on ochratoxin A (OTA) and aflatoxin B1 (AFB1), while the knowledge on citrinin (CIT), sterigmatocystin (STC) and cyclopiazonic acid (CPA) prevalence is still insufficient. Data on mould species overgrowing TMP surfaces and producing these mycotoxins as secondary metabolites depending on a number of factors are also scarce. Within the frame of the proposed project, mould species overgrowing the surface of the most prominent Croatian TMPs shall be identified using molecular techniques (Polymerase Chain Reaction, PCR); on top of that, genes responsible for mycotoxin production shall be pinpointed. The identified moulds shall be linked to the established sensory and physicochemical features of TMPs and mycotoxins occurrence. Concentrations of AFB1, OTA and CIT shall be determined using (ultra) high performance liquid chromatography combined with fluorescence detection (uHPLC-FLD). As for the STC & CPA determination, liquid chromatography tandem mass spectrometry (LC-MS/MS) techniques shall be developed, contributing thereby to the potential of analytical tools to be used in further research devoted to the prevalence of these mycotoxins worldwide. To the best of our knowledge, this research shall give the very first insight into the concentrations of each and every mycotoxin of relevance for meat products, taking thereby into account the type of TMPs and the impact of regional climate witnessed during the two production years. Based on the data on dietary habits of Croatian population, TMPs consumption-mediated consumer exposure to these mycotoxins shall be assessed. The results of this research shall serve as the cornerstone for Scientific Opinion drafting and a valuable rationale to be used by food safety authorities in stipulating the Maximum Levels (MLs) of mycotoxins in meat products, as well for producers striving to prevent TMPs contamination.]]></summary_en></project><project>
<id>7443</id><title_hr><![CDATA[Uloga fosfoinozitida u nastanku trombocita]]></title_hr><title_en><![CDATA[]]></title_en><user_id>35</user_id><user_firstLast_name>Antonija Jurak Begonja</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-7426</code><acronim><![CDATA[MkPI]]></acronim><duration>19.09.2018 - 29.12.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Fakultet biotehnologije i razvoja lijekova]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Biotechnology and Drug Development]]></institution_en><team_members_id>24298</team_members_id><team_members_names><![CDATA[ Doktorand: Ana Bura ]]></team_members_names><keywords_hr><![CDATA[megakariociti, trombociti, trombopoeza, endocitoza, fosfoinozitidi]]></keywords_hr><keywords_en><![CDATA[megakaryocytes, platelets, thrombopoiesis, endocytosis, phosphoinositides]]></keywords_en><summary_hr><![CDATA[Trombociti su neophodni za hemostazu te također posreduju u procesima različitih bolesti uključujući upale, metastaze, aterosklerozu. Liječenje leukemija i drugih malignih oboljenja ili transplantacije organa često dovode do smanjenja broja trombocita, te predstavljaju rizik od krvarenja. Trombociti nastaju iz citoplazme megakariocita (MK) u koštanoj srži u procesu trombopoeze. MK prolaze složen proces sazrijevanja koji vodi ka stvaranju dugih, razgranatih citoplazmatskih struktura – protrombocita. Molekularni mehanizmi koji reguliraju ove citoplazmatske promjene MK-a u velikoj mjeri su nepoznati. Naša preliminarna istraživanja pokazuju da određena vrsta fosfoinozitida (PI), fosfatidilinozitol 3-monofosfat (PI3P) ima glavnu ulogu u formiranju protrombocita u primarnim kulturama MK-a. U stanicama PI3P se nalazi u ranim endosomima i sudjeluje u endosomskom prometu. Naša je hipoteza da membranski promet reguliran PI3P-om u endocitnom putu znatno pridonosi biogenezi trombocita. Predloženi projekt istražit će točnu ulogu PI3P u stvaranju protrombocita. Koristit ćemo genetski napravljene  fluorescentne probe, tehniku koja se temelji na proteinskim domenama fuzioniranim s fluorescentnim proteinom eksprimiranim s retrovirusa, kako bi odredili lokalizaciju u stvarnom vremenu različitih PI u MK-ima i protrombocitima. Istražit ćemo kako interferencija PI3P funkcije utječe na sazrijevanje MK te utvrditi je li defekt ograničen na endosomski odjeljak. U svrhu utvrđivanja mehanizma djelovanja PI3P-a koristit ćemo genetski i farmakološki pristup kako bi ispitali je li progresija ranih u kasne endosome nužna za stvaranje trombocita. Osim toga, identificirat ćemo proteine koji vežu PI3P regulirajući endosomsku dinamiku važnu za stvaranje protrombocita. Ovo će istraživanje doprinijeti našem razumijevanju osnovnih molekularnih procesa trombopoeze koji bi mogli doprinijeti novim terapijskim strategijama u liječenju trombocitopenije.]]></summary_hr><summary_en><![CDATA[Platelets are essential for hemostasis and they also mediate diverse disease processes including inflammation, metastasis, atherosclerosis. Cancer and leukemia treatments or organ transplants often lead to reduced platelet numbers, putting patients at risk of bleedings. Platelets derive from cytoplasm of megakaryocytes (MKs) in the bone marrow in a process called thrombopoiesis. MKs undergo complex maturation process that leads towards extension of long, branched cytoplasmic structures called proplatelets that eventually release platelets. Molecular mechanisms that govern these elaborate cytoplasmic changes of MKs remain largely unknown. Based on primary MKs our preliminary studies show that one type of phosphoinositides (PIs), phosphatidylinositol 3-monophosphate (PI3P) has a major role in proplatelet formation. PI3P is concentrated in early endosomes and is involved in endosomal trafficking. Our hypothesis is that PI3P regulation of membrane traffic in the endocytic pathway contributes significantly to platelet biogenesis. This proposed project will reveal the exact role of PI3P in proplatelet formation. We will use genetically engineered fluorescent probes, a technique based on protein domains fused with fluorescent protein expressed from retroviruses, to define spatial and temporal localization of different PIs in MKs and proplatelets. We will investigate if interference of PI3P function affects MK maturation and examine if defect is confined to endosomal compartment. To determine mechanism of PI3P action we will use genetic and pharmacologic approaches to examine if progression of early to late endosomes is needed for platelet genesis. In addition, we will identify proteins  that act in concert with PI3P to regulate endosomal dynamics important for proplatelet formation. These studies will contribute to our understanding of basic molecular processes underlying thrombopoieses and might lead towards novel therapeutic strategies in treatment of thrombocytopenia.]]></summary_en></project><project>
<id>7444</id><title_hr><![CDATA[Ekologija i karakterizacija dva nova virusa vinove loze]]></title_hr><title_en><![CDATA[Ecology and characterization of two novel viruses infecting grapevine]]></title_en><user_id>21451</user_id><user_firstLast_name>Darko Voncina</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-1305</code><acronim><![CDATA[ENVISaGE]]></acronim><duration>01.12.2018 - 30.11.2022</duration><status>Završio</status><financ_value>153.945,19 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, Interdisciplinarne biotehničke znanosti, </scie_field_hr><scie_field_en>Agriculture, Interdisciplinary biotechnical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Agronomski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Agriculture]]></institution_en><team_members_id>4954, 13509, 24128, 23863, 24209, 11198, 26015, 855437, </team_members_id><team_members_names><![CDATA[Boris Lazarević, Zvjezdana Marković, Maher Al Rwahnih, Pierfederico La Notte, Angelo De Stradis, Darko  Preiner, Martin  Jagunić, Mladen Poletti Kopešić, ]]></team_members_names><keywords_hr><![CDATA[detekcija, distribucija, prijenos, zeljasti domaćini, biološke karakteristike, ozdravljivanje, utjecaj, elektronska mikroskopija]]></keywords_hr><keywords_en><![CDATA[detection,distribution, transmission, herbaceous hosts, biological properties, sanitation, impact, electron microscopy]]></keywords_en><summary_hr><![CDATA[Vinova loza je jedna od najstarijih kultura koja se uzgaja u svim dijelovima svijeta gdje za to  vladaju povoljni klimatski uvjeti. Osim povoljnih uvjeta za uzgoj, Hrvatsku karakterizira značajan broj autohtonih sorata vinove loze, a vinogradarstvo predstavlja važan dio nacionalnog gospodarstva. Do danas je kod loze utvrđeno više od 75 različitih virusa.  Virusne bolesti predstavljaju veliki ekonomski problem u poljoprivrednoj proizvodnji širom svijeta, posebno kod kultura s vegetativnim razmnožavanjem. Njihova kontrola se  uglavnom temelji na suzbijanju poznatih vektora (insekti, grinje, nematode), korištenju bezvirusnog sadnog materijala i konstantnom radu na klonskoj i zdravstvenoj selekciji. Uvođenjem tehnike sekvenciranja nove generacije (NGS) u dijagnostiku biljnih patogena, nekoliko novih virusa potvrđeno je u vinovoj lozi. Dva nova virusa, uvjetno nazvana G-virus vinove loze i badnavirus vinove loze 1, nedavno su primjenom NGS metode pronađeni kod hrvatskih autohtonih sorata. Međutim, biološki podaci o nedavno otkrivenim virusima vrlo su ograničeni ili ne postoje, a sposobnost otkrivanja velikog broja mogućih patogena ograničene je primjenjivosti ako ne postoje istraživanja koja opisuju njihove uloge i kako smanjiti njihov negativan utjecaj na ekonomski značajne kulture. Uzimajući u obzir  dogmu da se svi virusi smatraju patogenima dok se ne dokaže drugačije, cilj projekta je detaljnije istražiti dva nova virusa vinove loze. Projekt će rezultirati robusnim i pouzdanim testovima za detekciju dva virusa, podacima o njihovoj morfologiji i rasprostranjenosti u Hrvatskoj, načinu prijenosa (mehanički, vektori, sjeme, cijepljenje), alternativnim domaćinima, mogućnosti uklanjanja iz zaraženih biljaka i utjecaja na fiziološke procese kod različitih sorata u normalnim i sušnim uvjetima. Projekt će dati korisne podatke o ekonomskoj važnosti novih virusa, potrebi za regulacijom (karantena ili uvoz/ izvoz) zajedno s mogućnostima njihove odgovarajuće kontrole.]]></summary_hr><summary_en><![CDATA[Grapevine is one of the oldest crop cultivated in all parts of the word with appropriate climatic conditions. Beside favorable conditions for grapevine production, Croatia is characterized by significant number of autochthonous cultivars and viticulture is representing important branch of national economy. Up to date over 75 different viruses have been identified from grapevine. Viral diseases are currently a major economic problem in agriculture throughout the world, especially in crops with vegetative propagation. Their management is mainly based on control of known vectors (insects, mites, nematodes), use of virus-free planting material and constant work on clonal and sanitary selection. With implementation of next generation sequencing (NGS) in diagnostic of plant pathogens several novel viruses from grapevine were reported. Two novel viruses, tentatively named grapevine virus G and grapevine badnavirus-1, were recently reported from Croatian autochthonous grapevine varieties using NGS. However, biological information about recently reported viruses is very limited or non-existent, and the ability to detect large number of putative pathogens is of limited applied value if there are no studies describing their respective roles or how to reduce their impact to a crop of economic importance. Challenging the dogma that all viruses are considered pathogens till proved otherwise, aim of the project is detailed investigation or two novel viruses reported from Croatia. Project will resulted in robust detection assays for novel viruses, data about their morphology and distribution in Croatia, modes of spread (mechanical, vectors, seed, grafting), alternative hosts, sanitation and impact on physiological process of different grapevine varieties under normal and dry conditions. Project will generate beneficial data about economic importance of novel viruses, need for regulation (quarantine or import/export) together with options for appropriate management.]]></summary_en></project><project>
<id>7446</id><title_hr><![CDATA[Održiva proizvodnja biokemikalija iz sekundarnih lignoceluloznih sirovina ]]></title_hr><title_en><![CDATA[Sustainable production of biochemicals from waste lignocellulose containing feedstocks]]></title_en><user_id>4332</user_id><user_firstLast_name>Božidar Šantek</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-9717</code><acronim><![CDATA[OPB-SLS/SPB-LCF ]]></acronim><duration>01.11.2018 - 31.10.2022</duration><status>Završio</status><financ_value>199.084,21 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Biotehnologija, </scie_field_hr><scie_field_en>Biotechnology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Food Technology and Biotechnology]]></institution_en><team_members_id>5039, 4544, 4321, 450, 3709, 4912, 6032, 1307, 453, 4324, 5414, 4098, 4102, 4100, 4438, 23620, 23617, 23329, 864820, 4430, 26476, </team_members_id><team_members_names><![CDATA[Vesna  Zechner-Krpan, Draženka Komes, Ivan-Krešimir Svetec, Tonči Rezić, Vlatka Petravić Tominac, Sunčica Beluhan, Mirela Ivančić Šantek, Damir Stanzer, Jasna Mrvčić, Anamarija Štafa, Marina Svetec Miklenić, Antonija Trontel, Mladen Pavlečić, Mario Novak, Aleksandra  Vojvodić Cebin, Nenad Marđetko, Karla Hanousek Čiča, Ana Huđek, Angela Matanović, Arijana Martinić, Danijela Šeremet, ]]></team_members_names><keywords_hr><![CDATA[proizvodnja biokemikalija, lignocelulozne sirovine, integralni bioprocesi, procjena održivosti, procedura za povećanje mjerila]]></keywords_hr><keywords_en><![CDATA[biochemicals production, lignocellulose containing feedstocks, integral bioprocesses, sustainbility evaluation, scale-up procedure]]></keywords_en><summary_hr><![CDATA[Ovaj projekt bavi se razvojem održivih bioprocesa za proizvodnju biokemikalija [mikrobnih lipida (posebno poli-nezasićenih masnih kiselina), L-laktata, 2,3-butandiola i polifenola] iz sekundarnih lignoceluloznih sirovina (npr. ostataka šumarstva i prerade drva, pšenične slame, kukuruzovine i kukuruznih oklasaka, otpadne trave, kore banane i cikle, mahune graška, ljuske luka, ljuske kakaovog zrna i oraha). Predobrade tih sirovina provodit će se u visokotlačnom reaktoru uz primjenu metode koja koristi razrijeđenu kiselinu ili lužinu. U drugom stupnju predobrade, čvrsti ostatak (iz visokotlačnog reaktora) bit će podvrgnut procesu hidrolize pomoću komercijalnih enzimskih preparata ili mikroorganizama s relativno velikom celulitičkom aktivnošću. U ovom istraživanju dobiveni hidrolizati lignoceluloznih sirovina biti će analizirani, korigirat će im se sastav, te će se primijeniti za proizvodnju biokemikalija. Istraživanje proizvodnje biokemikalija bit će fokusirano na provođenje bioprocesa na polučvrstim ili čvrstim supstratima u horizontalnom rotirajućem cijevnom bioreaktoru. Odabrat će se najadekvatniji mikroorganizmi za proizvodnju proučavanih biokemikalija čije će osobine biti poboljšane primjenom metoda genetičkog inženjerstva. Za izdvajanje i pročišćavanje tih biokemikalija bit će razvijeni postupci koji će biti integrirani s procesom njihove proizvodnje da bi se poboljšali ekološki i ekonomski aspekti tih bioprocesa. Održivost proizvodnje proučavanih biokemikalija bit će procjenjena na osnovi LCA. Najefikasnija i održiva konfiguracija proučavanih bioprocesa će se definirati na osnovi LCA rezultata, te će se razviti procedura za povećanje mjerila. Procedura za povećanje mjerila će se bazirati na razvijenom integralnom matematičkom modelu bioprocesa i ostalim kriterijima za povećanje mjerila. Novi integrirani bioprocesi za proizvodnju biokemikalija iz sekundarnih lignoceluloznih sirovina glavni su rezultat ovog projekta.]]></summary_hr><summary_en><![CDATA[This project proposal is dealing with development of sustainable bioprocesses for the biochemicals [microbial lipids (especially polyunsaturated fatty acids), L-lactate, 2,3-butanediol and polyphenols] production from the waste lignocellulose containing feedstocks (e.g. forestry residues, wheat straw, corn stover and cobs, waste grass, banana and beetroot peels, pea pods, onion peels, cocoa bean husks and walnut shells). Pretreatment of these feedstocks will be performed in high pressure reactor combined with the use of dilute acid or alkaline methods. In second stage of pretreatment, the solid residues (from high pressure reactor) will be hydrolyzed be using commercial enzymes mixtures or microorganism with relatively high cellulolytic activity. In this research, obtained hydrolyzates of lignocellulose containing feedstocks will be analyzed, corrected their content and used for biochemicals production. The study of biochemicals production will be focused on the semi-solid or solid state fermentations in the horizontal rotating tubular bioreactor (HRTB). The most suitable microorganisms for these biochemicals production will be identified and improved by genetic methods. Separation and purification procedure for studied biochemicals have to be developed and integrated with their production in order to improve ecological and economical aspects of these bioprocesses. The sustainability of these biochemicals production will be evaluated through the Life Cycle Assessment (LCA). The most efficient and sustainable bioprocess configuration will be defined on the basis of LCA results and consequently scale-up procedure will be developed. The scale-up procedure will be based on the developed integral bioprocess mathematical model and other scale-up criteria. Project outcomes will be new integrated bioprocesses for biochemicals production from waste lignocellulose containing feedstocks.]]></summary_en></project><project>
<id>7448</id><title_hr><![CDATA[Sulfasoli: nova generacija kompleksnih funkcionalnih materijala]]></title_hr><title_en><![CDATA[Sulfosalts: new generation of complex functional materials]]></title_en><user_id>4897</user_id><user_firstLast_name>Denis Sunko</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-7828</code><acronim><![CDATA[SulfNewFunMat]]></acronim><duration>01.11.2018 - 31.10.2022</duration><status>Završio</status><financ_value>128.542,04 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, Kemija, </scie_field_hr><scie_field_en>Physics, Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>4289, 2708, 3420, 97, 3567, 3247, 23868, </team_members_id><team_members_names><![CDATA[Neven Barišić, Mario Basletić, Ivo Batistić, Ante Bilušić, Predrag Lazić, Petar Popčević, Marko  Kuveždić, ]]></team_members_names><keywords_hr><![CDATA[metalizacija, polarna veza, DFT, sulfidi, kuprati, sinteza, transport]]></keywords_hr><keywords_en><![CDATA[metallization, polar bond, DFT, sulphides, cuprates, synthesis, transport]]></keywords_en><summary_hr><![CDATA[Sulfasoli se uvode kao nova klasa elektronskih materijala koji premoštavaju raspon između dvije poznate klase visokotemperaturnih supravodiča, kuprata i pniktida, te su idealni kandidati za pojavu nove „prijelazne“ fizike. Glavna ideja projekta je eksperimentalno i teorijsko istraživanje veze između orbitalnog sastava aktivnih elektrona i osobina materijala. Ključni novi moment su p orbitale sumpora, koje su analogne kisikovim orbitalama u kupratima ili arsenovim u pniktidima. Budući da su sulfasoli manje ionske od oksida, pokazuju iznenađujuću kristalokemijsku fleksibilnosti i bolju podesivost valencije iona prijelaznih metala. Tako se pojavljuje širok raspon zanimljivih elektronskih, magnetičnih i mehaničkih svojstava. Visoka kompresibilnost sumporovih spojeva olakšava proučavanje utjecaja tlaka na strukturna i elektronska svojstva, u čemu podnositelji imaju posebnog iskustva.Predlažemo proučavanje faznog dijagrama K2(Cu,Fe)4S4 (murunskita), kao posebno izgledne sulfasoli, koji bi prema preliminarnim teorijskim računima moga pokazati niz zanimljivih fizičkih svojstava, uključujući supravodljivost i termoelektriciteta. Paralelno će se proučavati srodni sustavi (npr. BaVS3, anataza, kuprati). Zbog energetskih skala nižih nego u oksidima, čime se pojačava kovalentnost na štetu ioniciteta, te zbogi više mogućih oksidacijskih stanja sumpora, očekujemo da će naši odabrani sulfidi imati i širi raspon i finiju gradaciju ponašanja od oksida prilikom dopiranja, interkalacije, ili pod utjecajem uniaksijalnog ili hidrostatskog tlaka.Osim što je strukturalno analogan kupratima i pniktidima, murunskit nudi priliku dopiranja duž dvije elektronski aktivne osi. Nadamo se da će iskorištavanjem ovih mogućnosti murunskit sam za sebe postati nova paradigmatska klasa funkcionalnih materijala.]]></summary_hr><summary_en><![CDATA[Sulfosalts are introduced as a new class of electronic materials which bridge the gap between the two known classes of high-temperature superconductors, cuprates and pnictides, thus being an ideal candidate for novel “crossover” physics. The main idea is to investigate, experimentally and theoretically, the connection between the orbital content of the active electrons and the material properties. The key player are the sulphur p orbitals, directly analogous to those of oxygen in the cuprates or arsenic in the pnictides. Because sulphides are less ionic than oxides, they show considerable crystallochemical flexibility and superior tunability of the transition metal valences. This gives rise to a variety of interesting electronic, magnetic and mechanical properties. The large compressibility of sulphur compounds facilitates studies of structural and electronic properties of those systems under pressure, which is one domain of the applicants’ expertise.We propose to study the phase diagram of K2(Cu,Fe)4S4 (murunskite) as a particularly promising sulfosalt that could, according to preliminary theoretical calculations, exhibit a variety of exciting physical properties, superconductivity and thermoelectricity included. Related systems will be tackled in parallel (e.g., BaVS3, anatase, cuprates). Because the relevant energy scales are lower than in oxides, promoting covalency at the expense of ionicity, and allowing for several possible oxidation states of sulphur, we expect our sulphides to have a wider range and finer graining of behavior than oxides under doping, intercalation, and uniaxial or hydrostatic pressure.Besides being structurally analogous both to cuprates and to pnictides, murunskite offers the attractive opportunity of two electronically active doping axes. By exploring these opportunities, we hope for murunskite to become a paradigmatic class of modern functional materials by itself.]]></summary_en></project><project>
<id>7451</id><title_hr><![CDATA[Mikrobiom glavate želve (Carreta carreta): uvid u epizoičke i endozoičke zajednice (TurtleBIOME) UIP-05-2017-5635]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4337</user_id><user_firstLast_name>Sunčica Bosak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-5777</code><acronim><![CDATA[]]></acronim><duration>23.10.2018 - 23.12.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>25309</team_members_id><team_members_names><![CDATA[ Doktorand: Klara Filek ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>7455</id><title_hr><![CDATA[Višekromoforne probe za prepoznavanje pojedinih struktura DNA, RNA i proteina]]></title_hr><title_en><![CDATA[Multichromophore probes for recognition of particular DNA, RNA and protein structures]]></title_en><user_id>480</user_id><user_firstLast_name>Ivo Piantanida</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-5475</code><acronim><![CDATA[BioMultiChromoProbes]]></acronim><duration>16.11.2018 - 15.11.2022</duration><status>Završio</status><financ_value>131.528,30 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>1232, 2953, 444, 3684, 23618, 26666, 865429, </team_members_id><team_members_names><![CDATA[Ivo Crnolatac, Lidija-Marija Tumir, Vilko Smrečki, Dijana Saftić, Marija Matković, Ivona Krošl, Marta Košćak Košćak, ]]></team_members_names><keywords_hr><![CDATA[DNA, RNA, protein, fluorescencija, supramolekulsko prepoznavanje, bioaktivnost]]></keywords_hr><keywords_en><![CDATA[DNA, RNA, protein, fluorescence, supramolecular recognition, bioactivity]]></keywords_en><summary_hr><![CDATA[Molekularno prepoznavanje nukleinskih kiselina i proteina je od temeljne važnosti za život. Male molekule koje selektivno vežu specifične biomakromolekule stoga su vrlo zanimljive ne samo za razumijevanje takvih procesa već i za potencijalne medicinske primjene, kao lijekovi ili obilježavači za biooslikavanje i analitičke svrhe. U posljednjih 5 godina razvili smo u suradnji s našim partnerima niz novih fluorescentnih aminokiselina i oligopeptida koji su prepoznavali različite DNA ili RNA strukture. Također smo pokazali da se ne-kovalentna agregacija kromofora može koristiti za prepoznavanje DNA / RNA. Nedavno smo razvili inhibitore fluorescentnih enzima i nove mitohondrijske specifične fluorescentne markere. U ovom prijedlogu želimo koristiti veliku biblioteku fluorescentnih aminokiselina razvijenih u prethodnom HrZZ projektu (i pripremiti nove poboljšane), kao i naša znanja o agregaciji boja, te dizajnirati i pripremiti multikromoforne peptide s različito kombiniranim kromoforima (npr. FRET parovi) i DNA / RNA / proteinski ciljanim supstituentima. Takvi peptidni sustavi bi poslužili kao višenamjenski obilježavači za simultano obilježavanje (različitim spektrometrijskim odgovorima) nekoliko različitih sekundarnih struktura (npr. raznih ds- ili ss-DNA / RNA sekvenci, proteina). Alternativno, peptidi će biti dizajnirani za visoko selektivnu interakciju s određenim biološkim ciljem (npr. određeni ds- ili ss-DNA/RNA slijed, DPP III enzim ili amiloid-fibrilacijski peptidni slijed). Interakcija s DNA / RNA / proteinima proučavat će se UV / Vis, fluorescencijom, CD / LD spektroskopijom i DSC / ITC mikrokalorimetrijom, MS, NMR, CLSM.Prijedlog je u skladu s ciljevima HrZZ-a: a) suradnja s međunarodno dobro prepoznatim inozemnim znanstvenicima, b) osposobljavanje mladih istraživača u međunarodnom istraživačkom okruženju i c) očekivani rezultati imaju potencijal komercijalizacije kao nove biokemijski obilježavači / ili lijekovi. Troškovi projekta su 994.000,00 kn za 4 godine.]]></summary_hr><summary_en><![CDATA[Molecular recognition of nucleic acids and proteins is of fundamental importance for life. Small molecules selectively targeting specific biomacromolecules are therefore highly interesting not only for understanding of such processes but also for potential medicinal applications, as drugs or probes for bioimaging and analytical purposes. In the last 5 years we developed in collaboration with our partners a series of novel fluorescent amino acids and oligopeptides, which recognised various types of DNA or RNA structures. Also, we showed that non-covalent aggregation of chromophores could be used for DNA/RNA recognition. Very recently we developed fluorescent enzyme inhibitors and novel mitochondria-specific fluorescent markers. In this proposal we want to use large library of fluorophore-amino acids developed in previous CSF project (and prepare new improved ones), as well as our knowledge on dye aggregation, to design and build multichromophore peptides, with variously combined chromophores (e.g. in FRET pairs) and DNA/RNA/protein targeting substituents. Such peptides would serve as multi-purpose probes for the simultaneous sensing (by different spectrometric responses) of several different biomacromolecule secondary structures (e.g. various ds- or ss- DNA/RNA sequences, proteins). Alternatively, peptides will be designed for highly selective interaction with particular bio-target (e.g. particular ds- or ss- DNA, RNA, DPP III enzyme or amyloid-fibrillation peptide sequence). The interaction with DNA/RNA/proteins will be studied by UV/Vis, fluorescence, CD/LD spectroscopy and DSC/ITC microcalorimetry, MS, NMR, CLSM. Proposal addresses the most important CSF goals: a) collaboration with well-established international scientists, b) training of young researchers within the international research environment and c) the expected results have commercialisation potential as novel biochemical probes and/or drugs. Project costs are 994,000.00 HRK for 4 years.]]></summary_en></project><project>
<id>7457</id><title_hr><![CDATA[Izračunljive strukture, odlučivost i složenost]]></title_hr><title_en><![CDATA[Computable structures, decidability and complexity]]></title_en><user_id>19935</user_id><user_firstLast_name>Zvonko Iljazović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-7459</code><acronim><![CDATA[CompStruct]]></acronim><duration>01.10.2018 - 30.09.2022</duration><status>Završio</status><financ_value>88.127,94 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>23802, 21430, 23804, 21409, 23807, 19927, 23844, 23890, 19210, 24114, 25399, </team_members_id><team_members_names><![CDATA[Vedran Čačić, Luka Mikec, Mladen Vuković, Tin Perkov, Konrad Burnik, Lucija Validžić, Marko Horvat, Sebastijan Horvat, Bojan Pažek, Domagoj Vrgoč, Matea Kalinić, ]]></team_members_names><keywords_hr><![CDATA[izračunljiva analiza, izračunljiva topologija, izračunljivost skupa, odlučivost logika, složenost logika, ]]></keywords_hr><keywords_en><![CDATA[computable analysis, computable topology, computability of a set, decidability of logics, complexity of logics]]></keywords_en><summary_hr><![CDATA[Predloženi projekt trebao bi koordinirati i podržavati aktivnosti hrvatske grupe koja se bavi istraživanjima u matematičkoj logici i teorijskom računarstvu. Očekivane teme istraživanja su izračunljivost u analizi i topologiji te odlučivost i složenost raznih logika.Jedan od glavnih ciljeva ovog projekta je istraživanje nekoliko aspekata izračunljive analize. Posebno, planira se istraživanje uvjeta pod kojima je poluizračunljiv skup u izračunljivom metričkom ili topološkom prostoru izračunljiv. Poznato je da topologija ima važnu ulogu u opisu takvih uvjeta. Istraživanja planirana ovim projektom trebala bi doprinijeti daljnjem razumijevanju odnosa izračunljivosti i topologije. Nadalje, u ovom projektu će biti istražena razna svojstva struktura izračunljivosti na metričkim prostorima kao i odnos između separabilnih i maksimalnih struktura izračunljivosti. Također je u planu istražiti, s gledišta izračunljivosti, neka svojstva metričkih prostora na kojima je zadana određena geometrijska struktura. Logike interpetabilnosti su proširenja logike dokazivosti GL (Gödel-Löb). Glavno otvoreno pitanje u području je odrediti aksiomatizaciju logike IL(All), tj. logike interpretabilnosti koja je u presjeku svih sistema. Kao pokušaj odgovora na to glavno pitanje definirane su razna proširenja osnovnog sistema IL. U predloženom projektu trebala bi se istražiti potpunost nekih proširenja u odnosnu na generaliziranu Veltmanovu semantiku. Zatim, namjera nam je proučiti odlučivost i složenost, te implementirati algoritme. Posebno će se razmatrati složenost nekih deskriptivnih logika koje su povezane s nadogradnjama propozicijske dinamičke logike, a imaju primjenu u bazama podataka.]]></summary_hr><summary_en><![CDATA[The proposed project is intended to help coordinate and support the activities of the Croatian group which carries out research in mathematical logic and theoretical computer science. The envisioned topics of research are computability in analysis and topology and the decidability and complexity of various logics.One of the main objectives of this project is the investigation of several aspects of computable analysis. In particular, it is planned to examine conditions under which a semicomputable set in a computable metric or topological space is computable. It is known that topology plays an important role in the description of such conditions. The investigations planned in this project should contribute to the further understanding of the relationship between computability and topology. Furthermore, in this project will be investigated various properties of computability structures on metric spaces as well as the relationship between separable and maximal computability structures. It is also planned to examine, from the computability viewpoint, some properties of metric spaces on which certain geometric structure is given.Interpretability logics are extensions of provability logic GL (Gödel-Löb). The main open question in the area is to determine the axiomatization of the logic IL(All), i.e. the interpretability logic that is in the intersection of all the systems. In an attempt to answer this famous question, various extensions of the basic system IL were defined. The completeness of some extensions w.r.t. generalized Veltman semantics should be studied in this project. Further, we purpose to study decidability and complexity, and then we would like to consider implementation of algorithms for deciding provability. Particular consideration will be given to the complexity of some descriptive logics that are associated with the upgrades of the propositional dynamic logic and have application in databases.]]></summary_en></project><project>
<id>7458</id><title_hr><![CDATA[Fizika mnogočestičnih sustava - iskorištavanje svijeta kompleksnosti]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4336</user_id><user_firstLast_name>Osor  Slaven Barišić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-9860</code><acronim><![CDATA[COMPLEX_ORBIS]]></acronim><duration>20.09.2018 - 19.09.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut za fiziku]]></institution_hr><institution_en><![CDATA[Institute of Physics in Zagreb]]></institution_en><team_members_id>25108</team_members_id><team_members_names><![CDATA[ Doktorand: Juraj Krsnik ]]></team_members_names><keywords_hr><![CDATA[jaka međudjelovanja, nered, neravnotežna dinamika, kompleksni sustavi, izranjajuće pojave]]></keywords_hr><keywords_en><![CDATA[strong interactions, disorder, nonequlibrium dynamics, complex systems, emerging phenomena]]></keywords_en><summary_hr><![CDATA[Kompleksni sustavi karakterizirani su izranjajućim pojavama koje se u hijerarhiji skala pojavljuju vrlo daleko od onih skala koje karakteriziraju međuodnose između pojedinačnih sastavnica tih sustava. Zato takve pojave, vrlo različitih uzroka, konstantno privlače pažnju znanstvene zajednice. Bez obzira na inherentnu raznolikost, različite teme vezane za fiziku kompleksnih sustava dijele neke zajedničke koncepte i principe. Razumijevanje takvog fizikalnog bogatstva zahtijeva razvoj integrativnog teorijskog pristupa, sposobnog  tretirati probleme istovremeno preko različitih polja istraživanja. Osnovna ideja ovoga projekta je ostvarivanje široke strategije istraživanja, birajući probleme koji su izrazito aktualni unutar međunarodnih istraživanja, uz istovremeno održavanje bliske veze s eksperimentalnim rezultatima.Projekt se bavi izranjajućim pojavama u mnogočestičnim sustavima karakteriziranim jakim međudjelovanjem, neredom i/ili izvanravnotežnim stanjem. Predmeti predloženog istraživanja kreću se od specifičnih materijala od posebnog interesa u polju kondenzirane materije, do bioloških sustava, čije se funkcije u prirodnom okruženju u pravilu ostvaruju u izvanravnotežnim stanjima. Projekt je organiziran u tri radna paketa (WP), pri čemu se svaki od njih usredotočuje na jednu od klasa mnogočestičnih sustava u kojima se opažaju izranjajuće pojave. To su sustavi s jakim međudjelovanja, sustavi s neredom i sustavi izvan ravnoteže. Svaki WP je organiziran je u različite zadaće, koje iako su specifične za određeni WP dijele ujedno i značajan stupanj komplementarnosti, osiguravajući koherentnost i međupovezanost između WP-ova.Osim specifičnih znanstvenih doprinosa, namjera projekta je omogućiti i značajnu konsolidaciju teorijskih istraživanja na Institutu za fiziku, uključujući poboljšano okruženje za mlade istraživače. Podrška HrZZ-a projektu je stoga od ključne važnosti za održanje međunarodne kompetitivnosti članova tima, kao i za otvaranje novih perspektiva. ]]></summary_hr><summary_en><![CDATA[Complex systems are characterized by phenomena emerging in the hierarchy of scales far from those describing the numerous individual components. Such phenomena, which have a variety of origins, have repeatedly attracted the attention of the scientific community. Irrespective of the inherent diversity, some common concepts and principles are shared across different topics. Uncovering and understanding this richness requires the development of an integrative theoretical approach, capable of dealing with many-body problems across different fields. In this light, the main purpose of the present project is to enforce such a broad strategy by choosing problems that are highly relevant in current international research endeavors, while simultaneously maintaining a close connection with experimental results.The project addresses phenomena that emerge in systems characterized by strong interactions, disorder and/or the absence of equilibrium. The objects of the proposed research range from specific materials, the investigation of which is on the forefront of condensed matter research, to biological systems, functioning in their natural environment as physical systems far from equilibrium. The project is organized into work packages (WPs), each of which focuses on one important aspect of many-body systems exhibiting emergent phenomena. These are strong interactions, disorder and out-of-equilibrium dynamics. Each WP is organized around a series of different tasks, which, while WP-specific, share a significant degree of complementarity, ensuring coherence and interconnectedness across the WPs. Besides specific scientific contributions, the project aims to provide a significant consolidation of theoretical investigations at the Institute of Physics, including an improved environment for young researchers. The HrZZ’s support of the project is therefore of crucial importance for maintaining the international competitiveness of team members and for future perspectives.]]></summary_en></project><project>
<id>7459</id><title_hr><![CDATA[Platforma za satelitsko mjerenje elektromagnetskog zračenja]]></title_hr><title_en><![CDATA[Satellite-based measurement of electromagnetic radiation]]></title_en><user_id>7148</user_id><user_firstLast_name>Dubravko Babic</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-2504</code><acronim><![CDATA[CROSPERITY]]></acronim><duration>22.10.2018 - 21.10.2022</duration><status>Prekinut</status><financ_value>193.158,40 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, Računarstvo, Strojarstvo, Zrakoplovstvo, raketna i svemirska tehnika, Temeljne tehničke znanosti, Interdisciplinarne tehničke znanosti, </scie_field_hr><scie_field_en>Electrical engineering, Computer sciences, Mechnical engineering, Aerospace, missile and space engineering, Basic engineering sciences, Interdisciplinary technological sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>23858, 6686, 6955, 20069, 6893, 3652, 24438, 17790, 26560, 858311, </team_members_id><team_members_names><![CDATA[Josip Vuković, Zvonimir Šipuš, Tomislav Suligoj, Josip Lončar, Marko Bosiljevac, Ana Babic, Stefan Cikota, Jurica Jurec, Sonja Grgić, Tomislav Kos, ]]></team_members_names><keywords_hr><![CDATA[piko-sateliti, cubesat, geomagnetsko polje, svjetlosno zagađenje, promatranje Zemlje]]></keywords_hr><keywords_en><![CDATA[pico-satellite, cubesat, geomagnetic field, light pollution, Earth observation]]></keywords_en><summary_hr><![CDATA[Plan ovog projektnog prijedloga je razvoj platforme za satelitsko mjerenje elektromagnetskih emisija sa zemlje i iz svemira. Razvijena platforma će biti demonstrirana implementacijom (i) novog ultraljubičastog fotodetektora na temelju elementarnog bora (engl. pure B) u svrhu demonstracije robusnosti i primjenjivosti ovog tipa detektora na svemirske uvjete, (ii) sustava za spektralno razlučenje svjetla u svrhu identifikacije svjetlosnih izvora u svrhu praćenja razvoja svjetlosnog zagađenja sa Zemlje, tj. zamjene električnih žarulja i fluorescentnog osvjetljenja svjetlećim diodama, i (iii)  sustavom za mjerenje geomagnetskog polja u svrhu identifikacije fenomena koji utječu na navigaciju i praćenje satelita. Visina sa koje će se opservacije voditi je oko 600 km, a područje mjerenja bit će globalno.  U sklopu ovog projekta, razvit će se piko-satelit volumena 1 litre i težine 1 kg (CubeSat) koji će biti prilagođen za navedenu mjernu platformu.]]></summary_hr><summary_en><![CDATA[The purpose of this project is the development of a characterization platform for the measurement of electromagnetic emissions from Earth and space. The developed platform shall be demonstrated using (i) a novel ultraviolet photodetector based on pure Boron with the aim to demonstrate the robustness the technology and its suitability for space applications, (ii) a system for spectral resolving of light emitted from the earth to monitor light pollution and the global installation of light-emitting diodes in public places, and (iii)  a system  for monitoring of geomagnetic field which influences the navigation and tracking of satellites. The elevation from which these observations will be made is around 600 km above earth and the measurements will be global (entire earth).  This project plans to develop a pico-satellite with volume 1 liter and 1 kg weight, also known as the CubeSat, that will be customized to perform these functions. ]]></summary_en></project><project>
<id>7461</id><title_hr><![CDATA[Fizika teraskale na LHC-u i u svemiru]]></title_hr><title_en><![CDATA[]]></title_en><user_id>19131</user_id><user_firstLast_name>Oleg Antipin</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-6503</code><acronim><![CDATA[TsPhLC]]></acronim><duration>01.11.2018 - 30.10.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>25341</team_members_id><team_members_names><![CDATA[ Doktorand: Jahmall Matteo Bersini ]]></team_members_names><keywords_hr><![CDATA[neutrinske mase, asimptotskih sigurnih teorija, LHC, Standardnog modela,kosmologija]]></keywords_hr><keywords_en><![CDATA[neutrino mass, asymptotically safe theories, LHC, Standard Model, cosmology]]></keywords_en><summary_hr><![CDATA[Europska zajednica je uložila mnogo u razvoj LHC (Velikog hadronskog sudarača čestica) da bi se rješili neki osnovni problemi u fizici visokih energija. LHC Run-2 period koji upravo počinje bi se mogao pokazati kao najuzbudljivije vrijeme u fizicičestica u 21. stoljeću jer postoje naznake za postojanje novih čestica iz ranijih podataka s LHC-a. Ovaj prijedlog projekta će doprinjeti rješavanju fundamentalnih problema unutar fizike visokih energija u svjetlu novih LHC podataka. Cilj ovog projektnog prijedloga je da se dotaknu problemi proširenjem Standardnog modela (SM) jakih, slabih i elektromagnetskih interakcija koje su trenutno prihvačeni teorijski okvir za opisivanje fundamentalnih interakcija elementarnih čestica.Glavni kriterij za uspjeh je dovoljno poznavanje novih eksperimentalnih podataka od strane jakog teorijskoj tima vodećih svjetskih znanstvenika koji rade na povezivanjuizmeđu računa na superračunalnim rešetkama, teorijskih metoda teorije polja, fizike izvan SM i kozmologije. Zajedno sa svojim timom, doprinjet ću različitim relevantnim tehnikama isposobnošću da generiram svoja vlastita istraživanja što je dokazano mojim trenutnim postignutim znanstvenim rezultatima u postojećim suradnjama širom svijeta. Projekt ima četiri faze: 1. Prvo ćemo istražiti novu paradigmu asimptotske sigurnosti proširenja SM s glavnim ciljem formuliranja novih predviđanja za LHC Run-2. 2. S tim novim predviđanjima, cilj nam je proučavati temeljni problem masaneutrina. 3. U ovoj fazi, planiramo obaviti fenomenološke analize tih novih teorija koje vode do točnih predviđanja na ubrzivačima čestica. 4. Konačno, cilj nam je istraživati kozmološke posljedice tih novih modela s težištem naproučavanje tamne materije i bariogeneze.]]></summary_hr><summary_en><![CDATA[The European Community has invested heavily in the Large Hadron Collider (LHC) to solve fundamental problems within high energy physics. The LHC Run-2 period that begins now may prove to be the most exciting time for particle physics in 21th century as there are indications for existence of the new particles from the earlier LHC data. This proposal will contribute to solutions of fundamental problems within high energy physics in light of the new LHC data. The aim of this proposal is to address these problems by extending the Standard Model (SM) of strong, weak and electromagnetic interactions which is the currently accepted theoretical framework to describe interactions of fundamental particles. This is interesting because existing unsolved fundamental problems require new, beyond SM physics.The main criteria for success is a thorough understanding of the new experimental data by the strong theoretical team of the world’s leading researchers working at the interface between lattice supercomputing, field theoretical methods, beyond SM physics and cosmology.Together with my team, I will contribute with a variety of relevant techniques and ability to generate my own research proven by scientific results I currently achieved with existing collaborations worldwide.The project has four phases:1. First I will explore the new paradigm of the asymptotically safe extensions of the SM with the main goal to formulate new predictions for the LHC Run-2.2. With these new predictions, I aim to study the fundamental problem of neutrino mass.3. In this phase, I plan to perform phenomenological analysis of these new theories leading to accurate predictions for colliders.4. Finally, I aim to investigate cosmological implications of these new models with main focus on dark matter and baryogenesis.]]></summary_en></project><project>
<id>7464</id><title_hr><![CDATA[Razumijevanje, praćenje i analiziranje transparentnosti proračuna lokalnih jedinica: Primjer Hrvatske i Slovenije - Indeks otvorenosti lokalnih proračuna]]></title_hr><title_en><![CDATA[]]></title_en><user_id>13372</user_id><user_firstLast_name>Katarina Ott</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-8937</code><acronim><![CDATA[OLBI]]></acronim><duration>01.11.2018 - 15.12.2023</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, </scie_field_hr><scie_field_en>Economy, </scie_field_en><institution_hr><![CDATA[Institut za javne financije]]></institution_hr><institution_en><![CDATA[Institute of Public Finance]]></institution_en><team_members_id>25362</team_members_id><team_members_names><![CDATA[ Doktorand: Simona Prijaković ]]></team_members_names><keywords_hr><![CDATA[Local government, budget transparency, Open local budget index, Croatia, Slovenia]]></keywords_hr><keywords_en><![CDATA[lokalne jedinice, transparetnost proračuna, Indeks otvorenosti lokalnih proračuna, Hrvatska, Slovenija]]></keywords_en><summary_hr><![CDATA[Transparentnost proračuna lokalnih jedinica (TPLJ) od iznimne je važnosti budući da odluke lokalnih vlasti o trošenju javnih sredstava utječu na svakog građanina.  TPLJ označava u kojoj mjeri i koliko jednostavno građani mogu pristupati informacijama o prihodima i rashodima lokalnih proračuna. Transparentnost proračuna prvi je korak prema demokratizaciji proračunskog procesa i uključivanju građana u oblikovanje politika  i raspodjelu sredstava. Netransparentan proračun ne može se valjano analizirati, njegova se provedba ne može u potpunosti pratiti, niti se mogu vrednovati njegovi ishodi. Unatoč važnosti TPLJ-a, rijetka su istraživanja o njenim mjerenjima, uzrocima i posljedicama. Naš cilj je popuniti tu prazninu u literaturi istražujući: TPLJ u Hrvatskoj i Sloveniji, način na koji se ona mijenja tijekom vremena i razloge zbog kojih su neki lokalni proračuni transparentniji od drugih. Također ćemo nastojati odgovoriti na pitanja utječe li TPLJ na proračunske ishode u izbornim godinama, djeluje li na izborne rezultate i utječu li promjene TPLJ-a tijekom vremena na preferencije političara na vlasti i glasača u vezi s proračunskim ishodima. Oslanjajući se na postojeću literaturu i naše prijašnje radove, cilj nam je postaviti temelj za buduće istraživanje TPLJ-a, čiji će rezultat biti Indeks otvorenosti lokalnih proračuna (IOLP). Najprije ćemo uskladiti i prilagoditi već postojeću hrvatsku metodologiju (Ott, Bronić i Petrušić, 2013.; 2014.), kako bi se  mogla kontinuirano i na isti način primjenjivati na godišnjoj razini u Hrvatskoj i Sloveniji. Budući da će ovo  biti prvi put da se empirijski mjeri i prati TPLJ za prilično dugo razdoblje u dvije zemlje i budući da osim našeg rada (Ott, Bronić i Petrušić, 2013, 2014) nismo uspjeli naći niti jedan drugi rad o uzrocima i posljedicama TPLJ, naš kontinuirani projekt  će predstavljati jedinstven doprinos literaturi. Omogućit ćemo i donošenje boljih politika te veće sudjelovanje građana u odlučivanju o lokalnim proračunima. ]]></summary_hr><summary_en><![CDATA[Local government budget transparency (LBT) is of extreme importance as local authorities’ decisions upon spending public money have an impact on each and every citizen. LBT refers to how easily and to what extent citizens can access information on local government revenues and expenditures. Transparent budgets are a first step toward democratizing the budget process and giving citizens a say in policy formulation and resource allocation. A non-transparent budget cannot be properly analysed, its implementation cannot be thoroughly monitored nor can its outcomes be evaluated. Despite the importance of LBT, research into its measures, causes and consequences is thin. Our aim is to fill this literature gap and investigate: LBT in Croatia and Slovenia, how it changes over time and why some local budgets are more transparent than others. We will also try to answer: whether LBT affects budget outcomes in election years; whether it affects election outcomes and whether its changes over time influence incumbents&#39; and voters’ preferences regarding budget outcomes. Building upon the existing literature and our previous works, the aim is to construct the basis for future research into LBT, resulting in an open local budget index (OLBI). We will first harmonize and adapt the already existing Croatian methodology (Ott, Bronić and Petrušić, 2013; 2014) so that it can be further continually, annually applied in the same way in Croatia and Slovenia. Since this will be the first time that LBT will be empirically measured and monitored for a fairly long period of time in two countries, and since except for our own work (Ott, Bronić and Petrušić, 2013; 2014) we could find no other papers dealing with the causes and consequences of LBT, our continuous research will represent a unique contribution to the existing literature. Our results will also enable better policy-making and greater citizens’ participation in local budget deliberations.  ]]></summary_en></project><project>
<id>7468</id><title_hr><![CDATA[Predplanirana i reaktivna agilnost; razvoj i validacija specifičnih metoda mjerenja, utvrđivanje faktora utjecaja i učinkovitost transformacijskih postupaka]]></title_hr><title_en><![CDATA[Change of direction speed and reactive agility; development of the specific measurement tools, identification of predictors, and evaluation of training effects]]></title_en><user_id>147</user_id><user_firstLast_name>Damir Sekulić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-8330</code><acronim><![CDATA[RAGCODS]]></acronim><duration>01.10.2018 - 30.09.2022</duration><status>Završio</status><financ_value>74.338,36 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Kineziologija, </scie_field_hr><scie_field_en>Kinesiology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Kineziološki fakultet]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Kinesiology]]></institution_en><team_members_id>261, 175, 433, 149, 23813, 3198, 23926, 23986, 27180, 856001, </team_members_id><team_members_names><![CDATA[Mia Perić, Miodrag Spasić, Ognjen Uljević, Nataša  Zenić Sekulić, Ante Krolo, Dinko  Pivalica, Dean Kontić, Aleksandar Selmanović, Barbara Gilić, Toni Modrić, ]]></team_members_names><keywords_hr><![CDATA[testovi, prediktori, povezanost, utjecaj, agilnost otvorene vještine, agilnost zatvorene vještine]]></keywords_hr><keywords_en><![CDATA[tests, predictors, associations, influence, open skill agility, closed skill agility]]></keywords_en><summary_hr><![CDATA[Poznata je važnost agilnosti u sportu, ali je u skorije vrijeme prepoznata njena važnost i izvan natjecateljskog sporta. Utvrđeno je postojanje dva manifestacijska oblika agilnosti: pred-planirane agilnosti (CODS) i reaktivne agilnosti (RAG). Ciljevi projekta su: (i) razviti testove za mjerenje RAG i CODS, (ii) utvrditi faktore utjecaja na RAG i CODS, (iii) provjeriti učinkovitost transformacijskih programa (treninga) u razvoju RAG i CODS; za sportaše i kliničku populaciju. Uzorak ispitanika činiti će sportaši i klinička populacija (svi stariji od 18 godina). Skupinu sportaša činiti će podskupine: rukometaši (n = 60; 50% žena), košarkaši (n = 60; 50% žena), vaterpolisti (n = 60; 50% žena) i igrači fustala (n = 60; 50% žena). Kliničku populaciju činiti će osobe starije od 50 godina koje će se nalaziti na postoperativnom tretmanu nakon operativnog zahvata zamjena zgloba ili artroskopske operacije koljena (n=100; 50% žena). Zavisne varijable biti će novokonstruirani testovi RAG i CODS. Nezavisne varijable biti će antropometrijske mjere i mjere sastava tijela (za sve skupine), mjere brzine, sile, eksplozivne snage i reaktivne snage (za sportaše). Najprije će se razviti i validirati testovi RAG i CODS temeljeni na bežičnim tehnologijama. Potom će se utvrditi povezanost nezavisnih i zavisnih varijabli. Konačno, provjeriti će se efikasnost specifičnih treninga u razvoju RAG i CODS. Metode obrade rezultata uključivati će procjenu metrijskih karakteristika testova, univarijatne i multivarijatne analize povezanosti nezavisnih i zavisnih varijabli, te analize za procjenu učinkovitosti treninga. Radit će se o jednom od prvih istraživanja u svijetu u kojem će se razviti testovi za mjerenje RAG i CODS u različitim sportovima, koje će sistematski istražiti problem RAG i CODS kod analizirane kliničke populacije, te koje će istražiti učinkovitost treninga RAG i CODS. Projekt će imati izravnu primjenu u sportskom treningu i postoperativnoj rehabilitacijskoj praksi.]]></summary_hr><summary_en><![CDATA[The importance of agility in sport is well known, and since recently the significance of this quality is recognized in non-athletic population. Two facets of agility are recognized, differentiating reactive agility (RAG), and change of direction speed (CODS). The aims of this project are: (i) to develop RAG and CODS tests, (ii) to identify predictors of RAG and CODS, (iii) to define efficacy of training aimed at development of RAG and CODS; in athletic- and non-athletic (clinical) participants. The sample will comprise athletes, and clinical sample. The athletes will be involved in handball (n = 60; 50% females), basketball (n = 60; 50% females), water polo (n = 60; 50% females), and futsal (n = 60; 50% females), Clinical sample will comprise 100 participants (50% females, > 50 years) patients at postoperative treatment after joint replacement or arthroscopic knee surgery. The developed tests of RAG and CODS will be observed as dependent variables (DV). The independent (IV) variables will comprise anthropometric/body composition indices (for all participants), sprinting-, power-, force-, and reactive-strength-capacites (for athletes). First, tests of RAG and CODS will be evaluated for reliability and validity. Next, relationships between IV and DV will be established. Finally, the efficacy of the training aimed at improvement of RAG and CODS will be evaluated. Statistics will include analyses aimed at evaluation of (i) reliability and validity of tests, (ii) relationships among variables, and (iii) evaluation of training effects. This investigation will be one of the first which will systematically develop and validate RAG and CODS tests in different sports and clinical population, and probably the first one where the problem of development of RAG and CODS will be systematically investigated. The findings will have direct implications in sports training, as well as in postoperative rehabilitation of an investigated clinical sample.  ]]></summary_en></project><project>
<id>7469</id><title_hr><![CDATA[Prevencija hipoglikemije u trudnica s dijabetesom tipa 1]]></title_hr><title_en><![CDATA[Prevention of hypoglycemia in pregnant women with diabetes type 1]]></title_en><user_id>12342</user_id><user_firstLast_name>Marina Ivanisevic</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-1284</code><acronim><![CDATA[PRE-HYPO]]></acronim><duration>01.02.2019 - 31.01.2023</duration><status>Završio</status><financ_value>124.626,72 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Clinical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>12464, 12695, 12701, 12704, 23407, 23562, 23700, 7272, 12770, 12799, 6359, 12803, 26625, </team_members_id><team_members_names><![CDATA[Josip Đelmiš, Slavko Orešković, Josip Juras, Mislav Herman, Ksenija Tuškan, Mirta Starčević, Nada Sindičić Dessardo, Darko Marčinko, Lea Smirčić Duvnjak, Sandra Vučković-Rebrina, Ivana Pavlić-Renar, Vito Starčević, Matea Vukušić Mijačika, ]]></team_members_names><keywords_hr><![CDATA[dijabetes tipa 1, hipoglikemija, trudnoća, kardiovaskularna autonomna neuropatija, kognitivna funkcija, telomere]]></keywords_hr><keywords_en><![CDATA[diabetes type 1, hypoglycemia, pregnancy, cardiovascular autonomic neuropathy, cognitive function, telomere]]></keywords_en><summary_hr><![CDATA[Dijabetes tipa 1 (T1DM) u trudnoći donosi brojne probleme i za majku i za dijete. Ako se želi postići dobar ishod trudnoće, odnosno rađanje zdravoga djeteta, potreban je intenzivni pristup u postizanju normoglikemije prije začeća i tijekom trudnoće. Sa željom za što bolju kontrolu glikemije povisuje se rizik od hipoglikemije, s mogućim nepovoljnim komplikacijama trudnice/babinjače, uključujući komu, konvulzije i smrt. Cilj je prijedloga istraživanja prevencija, odnosno smanjenje pojavnosti hipoglikemije kod trudnice/babinjače s T1DM-om. Specifični ciljevi uključuju: a Izrada smjernica za sprječavanje nastanka hipoglikemije u trudnica s T1DM om na temelju testiranja potencijala biomarkera kao što je C-peptid, pouzdanog pretkazatelja teške hipoglikemije; b) Utvrđivanje utjecaja hipoglikemije na kardiovaskularnu neuropatiju; c) Utvrđivanje utjecaja hipoglikemije na kognitivnu funkciju i kvalitetu života trudnica kod uključenja u projekt, nakon porođaja i godinu dana nakon porođaja i njihove novorođenčadi i dojenčadi; d) Utvrđivanje utjecaja hipoglikemije na duljinu telomera u žena nakon porođaja i kod novorođenčeta. Istraživanjem će se utvrditi pojavnost i težina hipoglikemije u trudnica/rodilja/babinjača s T1DM-om u odnosu prema metaboličkoj kontroli uključujući maternalni i perinatalni ishod. Određivanjem C-peptida natašte i nakon jela te za vrijeme hipoglikemije uz ostale čimbenike kao što su kontinuirano mjerenje glukoze (CGM), trajanje dijabetesa, vrijednost HbA1c dobit će se siguran pretkazatelj nastanka hipoglikemije. Dobiven program edukacije i smjernice o pravodobnom prepoznavanju hipoglikemije koristit će se za prevenciju hipoglikemije u trudnica/babinjača. ]]></summary_hr><summary_en><![CDATA[Type 1 diabetes (T1DM) in pregnancy represents a burden for both a mother and a fetus. In order to accomplish a successful pregnancy outcome which includes delivery of healthy newborn, it is utmost importance to conduct the pre-pregnancy planning and achieve optimal glycemia in patient before conception, throughout pregnancy and in postpartum period. Nevertheless, the effort to reach the ideal glycemic control is often linked with increased risk of hypoglycemia which may lead to further maternal complications during pregnancy including coma, convulsions and death. The aim of this study is prevention and reduction of hypoglycemia prevalence in pregnant women with T1DM. Specific objectives include: a) establishing guidelines for prevention of hypoglycemia in pregnant women with T1DM based on biomarker potentials such as C-peptide, a reliable predictor of hypoglycemia; b) outlining the influence of hypoglycemia on cardiovascular neuropathy; c) identifying the influence of hypoglycemia on cognitive function and quality of life in pregnant women at booking, after delivery and one year after delivery, and in their newborns; d) determining the effect of hypoglycemia on telomere lengths in women after delivery, and their newborns an infants. PRE-HYPO consortium intends to provide a robust and evidence based data on incidence and clinical consequences of hypoglycemia in women with established T1DM during pregnancy/delivery/postpartum taking into an account metabolic control, maternal and perinatal outcome. The ambition of the proposal is to combine the results of the C peptide levels during fasting, post prandial and hypoglycemia events along with data from continuous glucose monitoring (CGM), duration of diabetes, HbA1c values in order to obtain reliable and realistic predictor of hypoglycemia. We will use specific training program and guidance for the timely recognition of hypoglycemia in order to prevent hypoglycemia in pregnant women. ]]></summary_en></project><project>
<id>7474</id><title_hr><![CDATA[Mikroskopska istraživanja induciranih faza u jako koreliranim elektronskim sustavima]]></title_hr><title_en><![CDATA[Microscopic study of induced phases in Strongly correlated electron systems]]></title_en><user_id>50</user_id><user_firstLast_name>Miroslav Požek</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-2970</code><acronim><![CDATA[MicroS]]></acronim><duration>01.10.2018 - 30.09.2023</duration><status>Završio</status><financ_value>153.958,46 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>3159, 3109, 3145, 3116, 17735, 23833, 25857, </team_members_id><team_members_names><![CDATA[Mihael Srđan Grbić, Damjan Pelc, Antonije Dulčić, Tonči  Cvitanić, Marija Vučković, Ana Najev, Ivan Jakovac, ]]></team_members_names><keywords_hr><![CDATA[jako korelirani elektronski sustavi, nuklearna magnetska rezonancija, tlak, kuprati, titanati, spinski lanci]]></keywords_hr><keywords_en><![CDATA[strongly correlated electron systems, nuclear magnetic resonance, pressure, cuprates, titanates, spin chains]]></keywords_en><summary_hr><![CDATA[Nove tehnologije počivaju na stalnom razvoju novih materijala, ali paradigmatični tehnološki skokovi se događaju kad se otkrivaju novi koncepti i/ili stanja tvari. Veliki teren za otkrivanje novih faza materije nalazimo među jako koreliranim elektronskim sustavima (SCES), natjecanje međudjelovanja i kvantne kritične pojave omogućuju bogatstvo uređenih stanja. Stoga je proučavanje koreliranih elektronskih sustava na samoj fronti istraživanja kondenzirane tvari.	SCES imaju vrlo složene fazne dijagrame s raznim kontrolnim parametrima kao što su temperatura, magnetsko polje, tlak ili dopiranje. Na faznim prijelazima fluktuacije mogu modificirati osnovna elektronska svojstva i stvoriti novu vrstu “kvantne kritične” materije, te time promijeniti svojstva materijala. Naša istraživanja usredotočit će se na nekoliko odabranih SCES tražeći odgovore na važna otvorena pitanja.	Proučavat ćemo okside trovalentnog titana, u kojima istaknuta pitanja obuhvaćaju magnetsku/orbitalnu kritičnu točku, ugađanje magnetizma i vodljivosti naprezanjem, te induciranu nisku spinsku dimenzionalnost. Naša istraživanja lantanovih kuprata trebala bi odrediti prirodu prijelaza između magnetskog izolatora i (supra)vodiča, te pokazati kako nabojno uređenje međudjeluje sa supravodljivošću pod tlakom u spoju dopiranom barijem. Istraživat ćemo i kvazi-1D Haldaneov spinski lanac s ciljem razumijevanja Bose-Einsteinove uređene faze i njezine evolucije u fazu s procjepom.	Popisu kontrolnih parametara koje već primijenjujemo u našem laboratoriju (temperatura, magnetsko polje, dopiranje) dodat ćemo izotropan i uniaksijalni tlak kako bismo istražili faze u nastajanju i fazne prijelaze. Upotrebljavat ćemo lokalne (NMR/NQR) i mezoskopske eksperimentalne metode (linearna i nelinearna vodljivost te toplinski kapacitet).	Projekt će rezultirati s nekoliko članaka u časopisima visoke kvalitete t dvjema doktorskim disertacijama. Usto, projekt će podići istraživačke kapacitete Fakulteta nabavom novog NMR spektrometra.]]></summary_hr><summary_en><![CDATA[New technologies rely on the continuing development of new materials, but technological paradigm shifts occur only when new concepts and/or states of matter are revealed. A large playground for discovering novel phases of matter is found in strongly correlated electron systems (SCES), where competing interactions and quantum criticality ensure an enormous wealth of ordering phenomena. The study of correlated electronic systems is thus on the forefront of condensed matter research.SCES display complex phase diagrams, with control parameters such as temperature, magnetic field, pressure or doping. At phase transitions, fluctuations can modify the basic properties of electrons and form new types of “quantum critical” matter, changing the overall properties of the material. Our research will focus on several prominent SCES, and will address important open questions.We will study trivalent titanium oxides, where the outstanding issues include a magnetic/orbital critical point, strain tuning of magnetism and conductivity, and induced low spin dimensionality. Our investigations of lanthanum copper oxides should determine the nature of the crossover between magnetic insulator and (super)conductor, and show how charge order and superconductivity interact in barium-doped compounds under pressure. We will also investigate a quasi-1D Haldane spin chain compound, aiming to understand the Bose-Einstein ordered phase and its evolution into the gapped phase.We will add isotropic and uniaxial pressure to the list of control parameters already used in our group (temperature, magnetic field, doping) to explore emergent phases and phase transitions. Experimental methods will include both local probes (NMR/NQR) and mesoscopic probes (linear and nonlinear conductivity, heat capacity).The project will result in several papers in high-quality research journals and two PhD theses. It will also increase the research capacities of the Faculty through the acquisition of a new NMR spectrometer.]]></summary_en></project><project>
<id>7477</id><title_hr><![CDATA[Imunosne i regenerativne implikacije korozije dentalnih materijala u djece i adolescenata]]></title_hr><title_en><![CDATA[]]></title_en><user_id>77</user_id><user_firstLast_name>Stjepan Špalj</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-2531</code><acronim><![CDATA[IMUNODENT]]></acronim><duration>01.08.2018 - 31.07.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Dentalna medicina, </scie_field_hr><scie_field_en>Dental medicine, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Medicine]]></institution_en><team_members_id>25209</team_members_id><team_members_names><![CDATA[ Doktorand: Martina Žigante ]]></team_members_names><keywords_hr><![CDATA[allergy, antibiotic resistance, nickel exposure, titan exposure, corrosion]]></keywords_hr><keywords_en><![CDATA[allergy, antibiotic resistance, nickel exposure, titan exposure, corrosion]]></keywords_en><summary_hr><![CDATA[Pomicanje zubi napravama baziranim na niklu i titanu ima veliki osteogeni potencijal i može regenerirati deficijentne dijelove alveolarne kosti i gingive te rehabilitirati narušene okluzijske odnose i žvačnu funkciju pacijenta. Zbog dugotrajnosti takve terapije paralelno se primjenjuju postupci i materijali za prevenciju te regeneraciju oštećene cakline i oralnih sluznica. Usna šupljina može se smatrati galvanskim člankom gdje su dentalne slitine elektrode, a elektrolit čine slina te oralni preventivni i regeneracijski agensi. Interakcija uzrokuje koroziju, smanjenje elastičnosti naprava, produkciju prevelikih sila, poremećaj regeneracije tikiva i nepopravljive štete na korijenu zuba, parodontu i kosti. Tijekom dugotrajne eksponiranosti otpušteni korozivni produkti u okolnim tkivima te transportirani slinom i krvlju mogu izazvati cijeli niz nusefekata. Alergije su danas sve češće i javljaju se sve ranije, a posebna skupina su djeca i mladi adolescenti u periodu pubertetskog rasta kada se razvija i imunološki sustav. Nikal je dugo poznati alergen i prisutan je u brojnim dentalnim legurama. Alergija na nikal događaje su u do 28.5% populacije i ne može se više smatrati niskim potencijalnim rizikom. U posljednje vrijeme reportira se i alergija na titan, za koji se smatralno da je biokompatibilan, a izloženi su mu brojni pacijenti s endoprotezama kuka, stentovima, dentalnim implantatima i ortodontskim napravama. Alergija na titan može biti odgovorna za neobjašnjene slučajeve neuspjeha i odbacivanja dentalnih implantata. Nikal i titan mogu uzrokovati rezistenciju bakterija na antibiotike što može stvarati probleme u terapiji niza infekcija koje su češće u djece i adolesceanta. Cilj je ovog projekta ispitati u kojoj mjeri i kojim mehanizmima korozija dentalnih materijala baziranih na niklu i titanu izaziva prethodno navedene biološke učinke.]]></summary_hr><summary_en><![CDATA[Tooth movement, based on nickel-titanium appliance, has great osteogenic potential, it can regenerate deficient alveolar bone sites and gingiva, rehabilitate deficient occlusal relationships and masticatory function. Due to prolonged therapy materials and techniques for prevention and regeneration of damaged enamel and oral tissues are concurrently used. Oral cavity can be considered as a galvanic cell, where saliva is electrolyte and dental alloys and oral agents are galvanic coupling components. Decreasing elasticity of orthodontic wires due to intraoral corrosion can produce excessive forces and therefore can disturb regeneration of tissues and irreparable damage to root and surrounding periodontium and bone. Due to long-term exposure corrosive products are released into adjacent tissues, saliva and blood. There from a number of undesired side effects can develop. Nowadays, the allergies occur more often and onset earlier during a lifetime. Children and young adolescents are undergoing pubertal growth, changes and maturation of immune system and particular attention should be paid to their exposure. Nickel has been well known allergen, present in many dental alloys. Nickel allergic hypersensitivity occurs in up to 28.5% of the population and it cannot be considered a low potential risk. Lately, allergic reactions to titanium were reported in patients with endoprosthesis and dental implants, contrary to the previously established biocompatibility. The occurrence of an allergy to titanium could be responsible for successive unexplained cases of failure of dental implants. Nickel and titan can enhance resistance of some bacteria to antibiotics which can produce problems in treatment of several infections that are more common in children and adolescents. The aim of this project is to explore to what extent and by which mechanisms does corrosion of dental materials based on nickel and titan produce above mentioned biological effects.]]></summary_en></project><project>
<id>7479</id><title_hr><![CDATA[Oscilatorna dinamika citoskeleta]]></title_hr><title_en><![CDATA[]]></title_en><user_id>7715</user_id><user_firstLast_name>Igor Weber</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-6409</code><acronim><![CDATA[OSCITON]]></acronim><duration>01.10.2018 - 31.12.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>25284</team_members_id><team_members_names><![CDATA[ Doktorand: Lucija Mijanović ]]></team_members_names><keywords_hr><![CDATA[citoskelet, mikrotubuli, motorni proteini, diobeno vreteno, stanično kretanje, Rho GTPaze, mikroskopija, teorijsko modeliranje]]></keywords_hr><keywords_en><![CDATA[cytoskeleton, microtubules, motor proteins, mitotic spindle, cell migration, Rho GTPases, microscopy, theoretical modeling]]></keywords_en><summary_hr><![CDATA[Oscilacije u citoskeletu važne su za biologiju stanice kao sredstvo prostorne i vremenske regulacije stanične organizacije, diobe stanica i njihove pokretljivosti. U projektu OSCITON istraživat ćemo dva oscilatorna procesa. Kao prvo, proučavat ćemo mehanizam oscilacija kinetohora koje pokreću mikrotubuli tijekom mitoze, te utjecaj kinezina-8 na taj proces. Te oscilacije stvaraju sile napetosti između sestrinskih kinetohora, bez kojih stanica ne može proći kontrolnu točku u metafazi. Oscilacije ćemo proučavati uz pomoć naprednih tehnika svjetlosne mikroskopije u HeLa stanicama u kojima ćemo eksprimirati tubulin-GFP i kinetohorni protein mRFP-Cenp-B, te smanjiti ili pojačati ekspresiju kinezina-8. Da bismo proučavali sile koje djeluju na kinetohore, promijenit ćemo ravnotežu sila laserskom mikrodisekcijom mikrotubula vezanih na kinetohore. Paralelno s eksperimentima razvit ćemo teorijski model, koji će omogućiti interpretaciju utjecaja kinezina-8 na oscilacije. Kao drugo, proučavat ćemo oscilatornu repolarizaciju stanica Dictyostelium tijekom njihovog nasumičnog gibanja. Pretpostavljamo da kompeticija efektorskih kompleksa DGAP1/korteksilin i Scar/Wave za zajednički aktivator Rac1 igra središnju ulogu u repolarizaciji. Kako bismo testirali ovu hipotezu, koristit ćemo novu fluorescentnu sondu za aktivni Rac1, stanice s poremećenom ravnotežom efektorskih kompleksa, te stanice sa reduciranom funkcionalnošću proteina Rac1. Eksperimentalno i teorijski ćemo proučavati dinamiku Rac1, njegovih efektora, te F-aktina u stanicama divljeg tipa i mutiranih sojeva. Ovaj će interdisciplinarni projekt omogućiti optimalno korištenje resursa i okupiti znanstvenike s iskustvom u širokom rasponu disciplina od molekularne i stanične biologije, biokemije, mikroskopije do teorijske biofizike. Udruživanjem svih istraživača iz područja dinamike citoskeleta u Hrvatskoj okupit ćemo tim koji će igrati važnu ulogu u tom području istraživanja na međunarodnoj razini.]]></summary_hr><summary_en><![CDATA[Oscillations in the cytoskeleton are of general importance in cell biology as a means of spatial and temporal regulation of the cellular organization, cell division and motility. The project OSCITON focuses on two oscillatory processes. First, we will investigate the mechanism of microtubule-driven kinetochore oscillations during mitosis, and the role of kinesin-8 motors in this process. These oscillations generate tension between sister kinetochores, which is required to pass the spindle checkpoint. We will use HeLa cells expressing tubulin-GFP and mRFP-CENP-B, a kinetochore protein, in combination with advanced light microscopy and depletion or overexpression of kinesin-8 motors. To study the forces acting on kinetochores, we will perturb the force balance by performing laser microsurgery of the microtubules attached to kinetochores. The experiments will be accompanied by the development of a theoretical model, which will allow us to explore the role of kinesin-8 in the oscillations. Second, we will study the oscillatory repolarization of Dictyostelium cells during random migration. We propose that the competition of DGAP1/cortexillin and SCAR/Wave complexes for the common activator Rac1 plays a central role in this process. To test this hypothesis, we will use a novel fluorescent probe for active Rac1 GTPases, generate cells with disturbed balance of Rac1 effectors, and cells deficient in functional Rac1. Dynamics of the probes for Rac1, its effectors, and F-actin will be studied experimentally in live cells and theoretically. This interdisciplinary project is designed to optimize the use of resources and bring together researchers with the expertise in a range of disciplines, including molecular and cellular biology, biochemistry, microscopy, and theoretical biophysics. Through joining forces of all investigators of the cytoskeletal dynamics in Croatia, we intend to assemble a team that will play a prominent role in this field of research internationally.]]></summary_en></project><project>
<id>7483</id><title_hr><![CDATA[Određivanje fizikalno-kemijskih svojstava i toksičnosti nanočestica srebra, bakra i plastike kao potencijalno štetnih novih materijala u obalnim vodama]]></title_hr><title_en><![CDATA[Understanding the physico-chemical behaviour and toxicity of silver, copper and plastic NANOparticles as Emerging Materials of Concern in coastal waters]]></title_en><user_id>4961</user_id><user_firstLast_name>Daniel Lyons</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-5351</code><acronim><![CDATA[NANO-EMC2]]></acronim><duration>01.10.2018 - 31.12.2022</duration><status>Završio</status><financ_value>120.656,31 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Interdisciplinarne prirodne znanosti, Fizika, Kemija, Biologija, </scie_field_hr><scie_field_en>Interdisciplinary natural sciences, Physics, Chemistry, Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>556, 439, 119, 528, 546, 11303, 12729, 4614, 17878, 28141, 858380, 865123, </team_members_id><team_members_names><![CDATA[Bojan Hamer, Dijana Pavičić-Hamer, Lorena Perić, Petra Burić, Ines Kovačić, Biljana Balen, Petra Peharec Štefanić, Petra Cvjetko, Lara Jurković, Ivana Hazdovac, Bruno Komazec, Matea Marelja, ]]></team_members_names><keywords_hr><![CDATA[istraživanja mora i ušće rijeke, nanočestica, nanoplastika, kinetika, toksičnost, bioakumulacija, klimatske promjene ]]></keywords_hr><keywords_en><![CDATA[marine and estuarine research, nanoparticle, nanoplastic, kinetics, toxicity, bioaccumulation, climate change]]></keywords_en><summary_hr><![CDATA[Usporedno s rastućom uporabom proizvoda koji sadrže nanočestice, očekuje se značajno povećanje njihovog oslobađanja u okolinu. Mnoga istraživanja vezana za ponašanje i sudbinu umjetno proizvedenih nanočestica (engl. engineered nanoparticles, ENPs) usmjerena su na kopnene vodene sustave (jezera, rijeke i podzemne vode) zbog očekivanja da će se nanočestice oslobođene u okolinu s vremenom razgraditi u tim istim sustavima bez značajnog prijenosa na ostale dijelove okoliša. Međutim, uzimajući u obzir mnoga nastanjena mjesta u obalnim područjima, potencijalno opterećenje velikom količinom nanočestica u ušćima rijeka kao i priobalnim vodama u nadolazećim godinama sve je značajnije. Budući da postoje dokazi da različite nanočestice mogu biti toksične za brojne organizme, posebno osjetljivi bi mogli biti organizmi u ušćima rijeka i u priobalnim područjima. Međutim, dostupne informacije vezane za ponašanje nanočestica u elektrolitima velike ionske jakosti, posebice učinak koji mogu imati njihovi omotači na koloidnu stabilnost, specijaciju i kinetiku, malobrojne su i nedorečene. Nadalje, trenutno postoji veoma malo raspoloživih podataka o međusobnom djelovanju nanočestica s širokim rasponom raznih organizama u bočatoj i obalnoj vodi. Ovaj će projekt istražiti fizikalno-kemijsko ponašanje nanočestica srebra, bakra i polimera/plastike različitih veličina i površinskih omotača, kao potencijalno opasnih materijala u vodenom stupcu bočatih i obalnih voda, uzevši u obzir abiotičke čimbenike kao što su salinitet, pH, koncentracija kisika i otopljena organsku tvar. Standardizirani biokemijski testovi, prilagođeni specifičnim svojstvima i učinku interferencije ENP, koristiti će se za mjerenje širokog raspona indikatora toksičnosti na izabrane organizme od algi i makroalgi do ježinaca, školjkaša i rakova. Ovim projektom omogućit će se po prvi puta cjelokupni pregled ponašanja nanočestica srebra, bakra i plastike u bočatoj vodi kao kompleksnoj zoni prijelaza iz slatkovodne u morsku vodu.]]></summary_hr><summary_en><![CDATA[In parallel with the growing use of nanoparticle-containing products, their release into the environment over the coming years is expected to increase significantly. Much of the research on the behaviour and fate of engineered nanoparticles (ENPs) in the environment has focused on terrestrial aquatic systems (lakes, rivers and groundwater) due to the expectation that ENPs would eventually be degraded in these systems without significant transport to other environmental compartments. However, with many large population centres located in near-coastal areas, the potential environmental load of nanoparticles in estuarine and coastal waters over the coming years is enormous. As there is increasing evidence that various nanoparticles may be toxic to a range of organisms, biota in estuarine and coastal waters may thus be particularly vulnerable. However, available data on how nanoparticles behave in high strength electrolytes, in particular the effect of their coating on colloidal stability, speciation or ion release kinetics are scarce. Further, there is little data on how such aged nanoparticles interact with the wide range of diverse organisms in brackish and coastal waters.This project will investigate the physico-chemical behaviour of silver, copper and polymer/plastic nanoparticles with a range of different sizes and surface coatings, as materials of concern, in brackish and marine waters based on a range of abiotic factors including salinity, pH, oxygen concentration and dissolved organic matter. Standardised biochemical tests, adapted to take into account the specific properties and interference effects of ENPs, will be used to measure a range of toxicity endpoints in selected organisms ranging from algae and macroalgae to urchins, mussels and crabs. The results from this project will provide for the first time a systematic overview of the behaviour of silver, copper and plastic nanoparticles in brackish water as a complex transition zone from fresh to salt water.]]></summary_en></project><project>
<id>7484</id><title_hr><![CDATA[Sinteza naprednih anorganskih katalizatora s povećanim brojem kiselih mjesta]]></title_hr><title_en><![CDATA[]]></title_en><user_id>609</user_id><user_firstLast_name>Josip Bronić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-1739</code><acronim><![CDATA[SAdInCat]]></acronim><duration>05.09.2018 - 31.12.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>25291</team_members_id><team_members_names><![CDATA[ Doktorand: Glorija Medak ]]></team_members_names><keywords_hr><![CDATA[zeolitni katalizatori, hijerarhijski zeoliti, hibridni materijal, nano-zeoliti, mokra impregnacija, converzija metanola u olefine, ]]></keywords_hr><keywords_en><![CDATA[zeolite catalyst, hierarchical zeolites, hybrid materijal,  nano-zeolites, wet impregnation, methanol to olefin conversion, ]]></keywords_en><summary_hr><![CDATA[Zeoliti su mikroporozni alumino-silikatni materijali vrlo dobro definirane kristalne strukture i termičke stabilnosti. Zahvaljujući svojoj strukturi, kanali i otvori pora mogu biti raznih veličina (0.2-1.3 nm) i oblika. Broj dostupnih Lewis-ovih (kadkad i Bronsted-ovih) kiselih mjesta na čvrstim katalzatorima, kao što su zeoliti, je od najveće važnosti za efikasnost katalizirane organske reakcije. U cilju razjašnjenja utjecaja različitih zeolitnih struktura (MFI, MOR, BEA, FAU) na katalitička svojstva za pretvorbu metanola u olefin, sintetizirat će se kristali različitih zeolita (ZSM-5, mordentie, beta, ZY) mikrometarske veličine. Poboljšanje njihovih katalitičkih mogućnosti će se realizirati sustavnim studiranjem preko dva pristupa: - povećanjem dostupne površine na kristalima i - povećanjem broja kiselih mjesta.Površina kristala može se povećati kroz redukciju njihove veličine (kroz sintezu nanometarskih kristala) ili pravljenjem većih pora na kristalima mikrometarske veličine. Mezoporoznost kristala će se postići sintezom hierarhijskih zeolita koristeći dva (ili više) templata za sintezu, kao i tehnikom dealuminacije/desilikacije. Drugi način povećanja broja kiselih mjesta u pripravljenim zeolitima je uvođenje određenih kationa metala (Ti, Zr, Fe, Sn) koristeći ionsku zamjenu u čvrstom stanju metodom mljvenja i/ili mokrom impregnacijom. Broj katalitičkih kiselih mjesta će se određivati uporabom vacuum FTIR spektroskopije adsorbiranog piridina ili sličnih organskih molekula.Dodatni post-sintetski tretman pripravljenih hierarhijskih zeolita, provodit će se ugradnjom nanometarskih čestica metalnih-oksida (priređenih sol-gel postupkom) u njih da čine hibridne (kompozitne) katalizatore. Mnoge tehnike/metode će se koristiti za karakterizaciju strukturnih, čestičnih i katalitičkih svojstava uzoraka: PXRD, AAS, OM, SEM, TEM, LLS, FTIR, DR-UV/Vis, NMR, TG-DTG, N2 adsorption/desorption, PALS.]]></summary_hr><summary_en><![CDATA[Zeolites are microporous alumino-silicate materials of very well defined crystal structure and thermal stability. Due to their structure, a crystal channels and pore openings can be of various size (0.2-1.3 nm) and shape.The number of available Lewis&#39; (sometimes Bronsted) acid sites at solid state catalysts, such as zeolites, is crucial for efficiency of catalysed organic reactions. In order to elucidate the role of different zeolite structures (MFI, MOR, BEA, FAU) on catalytic properties for methanol to olefin conversion, various micrometer sized zeolite crystals (ZSM-5, mordentie, beta, ZY) will be synthesized. Improvement of their catalytic abilities will be realized by systematic study via two approaches: - increase of available surface at crystals, and - increase of the number of acid sites.The crystals surface can be enlarged through reduction of its size (by synthesis of nanometer sized crystals) or by creation of larger pores on micrometer sized crystals. Mesoporosity of the crystals will be obtained by synthesis of hierarchical zeolites using dual (or multi) template synthesis and by dealumination/desilication technique. Another way to increase the number of acid sits in prepared zeolites is introduction of certain metal cations (Ti, Zr, Fe, Sn) exploiting solid state ion exchange via grinding or/and via wet impregnation. The number of catalytic acid sites will be determined using vacuum FTIR spectroscopy of adsorbed pyridine or similar probe molecules.Additional post-synthesis treatment of obtained hierarchical zeolites will be done through incorporation of the nanometer sized metal-oxides (obtained by sol-gel method) to form hybrid (composite) catalyst. Many techniques/methods will be used for characterization of samples structural, particulate and catalytic properties, such as: PXRD, AAS, OM, SEM, TEM, LLS, FTIR, NMR, DR-UV/Vis, TG-DTG, N2 adsorption/desorption, PALS.]]></summary_en></project><project>
<id>7488</id><title_hr><![CDATA[Semantičke domene deiktičkih riječi: Istraživanje brzih semantičkih procesa u jeziku ]]></title_hr><title_en><![CDATA[Semantic domains of deictic terms: Investigating the nature of fast meaning processes in language]]></title_en><user_id>7114</user_id><user_firstLast_name>Marija Brala-Vukanović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-2243</code><acronim><![CDATA[DeicTeS]]></acronim><duration>01.11.2018 - 31.10.2022</duration><status>Završio</status><financ_value>39.575,29 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Interdisciplinarne humanističke znanosti, Filozofija, Filologija, </scie_field_hr><scie_field_en>Interdisciplinary humanities, Philosophy, Philology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Filozofski fakultet u Rijeci]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>23887, 5309, 23898, 28939, 4040, </team_members_id><team_members_names><![CDATA[Peter Gärdenfors, Mihaela Matešić, Danijela  Trenkic, Biljana Stojanovska, Ana Meštrović, ]]></team_members_names><keywords_hr><![CDATA[deikse, kognitivna semantika, brzosemantičko procesiranje, demonstrativi, odnos jezika i geste]]></keywords_hr><keywords_en><![CDATA[deixis, cognitive semantics, fast semantic processing, demonstratives, language - gesture ralation]]></keywords_en><summary_hr><![CDATA[Deikse u jeziku i njihova semantika sržna su tema ovoga projekta. Polazeći od teorije prema kojoj se deiktičkim riječima pridjeljuje značenje tzv. brzim semantičkim procesom, analiziraju se deiktičke riječi u odabranim jezicima: engleskome, talijanskome, hrvatskome, makedonskome, bugarskome i njemačkome. Analiza se provodi korpusnim metodama te zatim introspektivno, s ciljem konstruiranja značenjske radijalne mreže svake proučavane deiktičke kategorije i deiktičke riječi. Na temelju teorijskoga i introspektivnoga pristupa provodi se zatim i empirijsko istraživanje koje ima za cilj proučiti psiholingvističke aspekte brzoga semantičkog procesiranja.Istraživanjem provedenim na opisani način donose se novi uvidi u: a) značenjske domene koje se izražavaju deiktičkim riječima, b) kognitivne i jezične mehanizme koji su uključeni u brze semantičke procese, c) razliku između brzih i sporih semantičkih jezičnih procesa, d) razlike između semantičkih i pragmatičkih funkcija deiktičkih riječi.Sve u svemu, cilj je projekta pružiti nove spoznaje o strukturi deiktičkih riječi, njihovim funkcionalnim (gramatičkim), semantičkim i pragmatičkim obilježjima. Poseban je cilj pritom pridonijeti daljnjemu razumijevanju strukture deiktičkoga sustava upravo hrvatskoga jezika. Projektom se stoga omogućuje i veća vidljivost te dostupnost hrvatskoga jezičnog materijala u (kognitivno)lingvističkome istraživačkom prostoru u međunarodnoj zajednici. Naposljetku, ovakav sustavan lingvistički opis strukturnih (funkcionalnih, semantičkih i pragmatičkih) aspekata deiksa primjenjiv je i u drugim znanstvenim područjima i poljima, ponajprije u psihologiji i neurolingvistici. Povezivanjem sa suvremenim istraživanjima neurolingvističkih procesa koji upravljaju proizvodnjom i recepcijom deiktičkih riječi,  rezultati ovoga projekta iskoristivi su također na područjima jezičnoga poučavanja te rehabilitacije govora.]]></summary_hr><summary_en><![CDATA[The focus of this project is on deixis in language. Following the position that deictic terms are given meanings by the fast semantic process, we will analyse deictic words in a set of languages (English, Italian, Croatian, Macedonian, Bulgarian, and German). Methodologically, an initial literature review will be followed by corpus analysis, subsequently followed by introspective data analysis. The aim is to construct a motivated radial network for each deictic term and, subsequently, each deictic category, under examination. The theoretical and introspective segment of project activities will be followed by work on an empirical study, aimed at investigating the psycholinguistic aspects of fast semantic processing.The investigation is aimed at providing new insights into: a) the semantic domains expressed by deictic words; b) the cognitive and linguistic mechanisms involved in fast semantic processes; c) the difference between fast and slow linguistic processes d) the differences between semantic and pragmatic functions of deictic terms.Ultimately, the objective of the project is to provide new insights into the structure of deictic terms; their functional (grammatical), semantic and pragmatic features, but also, more specifically, to contribute to the understanding of the structure of the deictic system in the Croatian language, thus providing visibility and availability of the Croatian data. Finally, by providing a detailed account of the structural (functional, semantic and pragmatic) elements of deictic elements in language, we also hope to offer useful insights for psychologists and neurolinguistics. In fact, one of air aims is to link our findings to the current knowledge regarding the neurolinguistic processes underlying the production and reception of deictic terms, hopefully providing useful information for fields outside linguistics, e.g. language teaching methodology or speech therapy.]]></summary_en></project><project>
<id>7489</id><title_hr><![CDATA[Biokemijski odgovori površinskog sloja oligotrofnog područja Jadranskog mora na atmosfersko taloženje]]></title_hr><title_en><![CDATA[Biochemical responses of oligotrophic Adriatic surface ecosystems to atmospheric deposition inputs]]></title_en><user_id>84</user_id><user_firstLast_name>Sanja Frka Milosavljević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-3105</code><acronim><![CDATA[BiREADI]]></acronim><duration>29.10.2018 - 28.10.2022</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Interdisciplinarne prirodne znanosti, Kemija, Biologija, Geofizika, </scie_field_hr><scie_field_en>Interdisciplinary natural sciences, Chemistry, Biology, Geophysics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>17873, 5789, 986, 23793, 23794, 17849, 23380, 23367, 85, 81, 106, 4294, 23848, 25777, 25845, </team_members_id><team_members_names><![CDATA[Ana  Cvitešić Kušan, Sanda Skejić, Tvrtko Smital, Sonja Vidič, Vedrana Džaja Grgičin, Tihana Novak, Ranka Godec, Silva Žužul, Abra Penezić, Blaženka Gašparović, Slađana Strmečki Kos, Ivan Bešlić, Stjepana Brzaj, Andrea Milinković, Saranda Bakija Alempijević, ]]></team_members_names><keywords_hr><![CDATA[atmosfersko taloženje, površinski (mikro)sloj mora, Jadransko more, fitoplankton, hranjive soli, organska zagađivala, tragovi metala, površinski film]]></keywords_hr><keywords_en><![CDATA[atmospheric deposition, sea surface (micro)layer, Adriatic Sea, phytoplankton, macronutrients, organic pollutants, trace metals, surface films]]></keywords_en><summary_hr><![CDATA[Najizazovnija područja istraživanja globalnih klimatskih promjena danas uključuju kompleksna međudjelovanja biologije i kemije površinskih voda, atmosferske kemije te klime koja bi mogla imati još veći značaj u budućim klimatskim scenarijima. Koristeći multidisciplinarni, cjeloviti pristup, BiREADI ima za cilj ispitati utjecaje atmosferskog taloženja (AT) na složene biokemijske odgovore oligotrofnih vodenih sustava; primarno fitoplanktonskih zajednica te, posljedično, i na kemijske promjene u površinskim slojevima, uključujući mikrosloj na granici faza zrak-voda. Predložen je fazni pristup i specifični ciljevi: (I) procijeniti koncentracije, izvore i taložne tokove atmosferskih sastavnica te prirodu obogaćenja površinskih slojeva mora hranjivim solima, tragovima metala i organskim zagađivalima, (II) procijeniti utjecaje okolišnog AT na fiziologiju i biomasu prirodne planktonske populacije, a time i na kemiju površinskih slojeva mora, (III) dobiti uvid u mehanizme kojima AT utječe na morski fitoplankton, ali i procijeniti toksične učinke sinergijskog djelovanja atmosferskih zagađivala na različite razine biološke organizacije vodenih sustava, (IV) bolje razumijevanje prirode varijabilnosti biogene organske tvari  vodenih površinskih slojeva pod utjecajem AT te mehanizama stvaranja površinskih filmova i njihovih svojstava. BiREADI će značajno doprinijeti temeljnom razumijevanju povezanosti procesa AT i biokemijskih odgovora morskih površinskih sustava primjenom najsuvremenijih laboratorijskih ispitivanja, modeliranja, složenog terenskog rada, uključujući i mezokozmos na području srednjeg Jadrana–oligotrofnoj zoni i ključnom području proučavanja biokemijskih učinaka AT na Jadransko more.]]></summary_hr><summary_en><![CDATA[Complex interactions between surface water chemistry, phytoplankton, atmospheric chemistry, and climate are among the most challenging global climate issues today, and should become even more pronounced in future climate scenarios. With a holistic, multidisciplinary approach, the BiREADI is designed to assess the impact of atmospheric deposition (AD) on complex biochemical responses of oligotrophic systems, considering the importance of promotion and inhibition effects on phytoplankton, and the consequent altering of the surface water chemistry, including the sea surface microlayer at the air-water interface. To achieve the main project goals, a phased approach is proposed: Phase I - to evaluate concentrations, sources and deposition fluxes of atmospheric constituents, and to get insight into the nature of enrichments of macro-nutrients, trace metals and organic pollutants within the sea surface layers; Phase II - to assess the impact of ambient AD from diverse sources on the physiology and biomass of the natural plankton population, and consequently on the chemistry of the sea surface layers; Phase III - to get insight into the mechanisms by which AD affects marine phytoplankton, but also to assess the toxic effects of atmospheric pollutants that can interact synergistically on various levels of biological organisation in aquatic systems; Phase IV - to better understand the nature of biogenic OM variabilities within the aqueous surface layers affected by AD inputs with the consequences on the surface film formation and properties. The BiREADI will make a significant progress in the fundamental understanding of the linkage between AD inputs and complex surface ocean biochemical responses by a state-of-the-art laboratory and modelling studies, and by comprehensive field work including the mesocosm experiment at the Middle Adriatic - an extremely oligotrophic water zone and the «hotspot» area to study the biochemical effects of AD to the Adriatic Sea.]]></summary_en></project><project>
<id>7496</id><title_hr><![CDATA[Ciljano liječenje, stanični mikrookoliš i tumorska distribucija u kroničnoj limfocitnoj leukemiji (B-KLL) ]]></title_hr><title_en><![CDATA[Targeted therapy, cell microenvironment and tumor distribution in B-cell chronic lymphocytic leukemia (B-CLL)]]></title_en><user_id>1222</user_id><user_firstLast_name>Ozren Jakšić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-3453</code><acronim><![CDATA[TTMTDCLL]]></acronim><duration>01.10.2018 - 31.03.2024</duration><status>Završio</status><financ_value>108.832,70 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Kliničke medicinske znanosti, Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Clinical sciences, Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Klinička bolnica "Dubrava", Zagreb]]></institution_hr><institution_en><![CDATA[Dubrava Clinical Hospital, Zagreb]]></institution_en><team_members_id>6760, 6139, 4556, 19193, 4697, 7198, 5917, 6578, 6577, 19259, 23847, 23838, 6997, </team_members_id><team_members_names><![CDATA[Vlatko Pejša, Silvia Deaglio, Branimir Jakšić, Renata Huzjan Korunić, Branimir Gizdić, Vlatka Pandžić Jakšić, Zdravko Mitrovic, Mario Piršić, Zorana Miletić, Anteja Krištić, Marija Ivić, David Čičić, Željko Prka, ]]></team_members_names><keywords_hr><![CDATA[KLL, mikrookoliš, ciljano liječenje, tumorska distribucija, B-receptor, bcl-2]]></keywords_hr><keywords_en><![CDATA[CLL, microenvironment, targeted therapy, tumor distribution, B receptor, bcl-2]]></keywords_en><summary_hr><![CDATA[Fenomen  tumorske distribucije (TD) u B-kroničnoj limfocitnoj leukemiji (B-KLL) usko je povezan s interakcijom između neoplastičnih B-KLL stanica i odgovarajućeg mikrookoliša (ME) što je sada u središtu translacijskog istraživanja zbog intrigantnih implikacija na novu terapijsku paradigmu. Predloženo istraživanje predstavlja inovativni pristup istraživanju uloge TD i ME u B-KLL. Ciljevi su ispitati neovisni doprinose i učinke (1) kvantificirane TD primjene na aktualne standardne kriterije praćenje kao i na identifikaciju ranih prediktora odgovora na nove terapije; (2) ekspresijskog profila površinskih receptora / liganda te unutarstaničnih molekula B-KLL limfocita na objašnjenje razlika koje proizlaze iz uzorkovanja iz različitih mikrookoliša (intraklonalna raznolikost) i (3) dinamike ekspresijskog profila molekula na objašnjavanje promjena koje proizlaze iz nove terapijske intervencije. Praćenjem kohorte B-KLL bolesnika klinički i radiološki vrednovat ćemo kriterije za praćenje i prognostičke prediktore. Imunofenotipizacijom  protočnom citometrijom i imunocitno- i histokemijom odredit će se profil adhezijskih molekula, kemokinskih receptora, bcl-2 molekula i drugih relevantnih površinskih i unutarstaničnih molekula. Analizom i povezivanjem podataka na kliničkoj i staničnoj razini prikladnim univarijatnim, multivarijatnim te istraživačkim tehnikama upotrijebit će se za karakterizaciju biološke pozadine raspodjele tumora i odgovora na nove terapije. Očekivani doprinos istraživanja je u poboljšanju kriterija dijagnostike i praćenja te ranih prediktora odgovora na nove lijekove. Ovi rezultati mogu se lako provesti u kliničkoj praksi. Na staničnoj razini očekujemo doprinos boljem razumijevanju molekularnih mehanizama kruženja i nastanjivanja B-KLL limfocita te odgovora na ciljanu terapiju. Ovi rezultati mogu pomoći u prepoznavanju, karakterizaciji, modeliranju i ciljanju važnih B-KLL signalnih putova.]]></summary_hr><summary_en><![CDATA[The phenomenon of Tumor Distribution (TD) in B-chronic lymphocytic leukemia (B-CLL) is closely related to interaction between neoplastic B-CLL cells and respective microenvironment (ME) and is now in the focus of translational research because of the intriguing implications on new therapeutic paradigm. The proposed research presents an innovative approach to study the role of TD and ME in B-CLL. Objectives are to investigate independent contribution and effects of (1) quantified TD application on current standard monitoring criteria improvement and to identification of early response predictors for novel therapies; (2) the B-CLL lymphocytes surface receptor/ligands and intracellular molecules expression profile on explanation of differences resulting from different sampling microenvironment (intraclonal diversity) and (3) molecule expression profile dynamics on explanation of changes resulting from new treatment intervention. We will evaluate clinically and radiologically cohort of patients to study monitoring criteria and prognostic predictors. Immunophenotyping by flow cytometry and immunocyto- and histochemistry will be used to determine profiles of adhesion molecules, chemokine receptors, bcl-2 molecules and other relevant surface and intracellular molecules. Appropriate univariate and multivariate analysis, exploratory techniques relating data at clinical and cellular level will be used for characterization of biological background of tumor distribution and response to novel treatments. We expect contribution in improving of diagnostic and follow-up criteria and early response predictors for novel treatments. These results can be readily implemented in clinical practice. At a cellular level we expect the contribution to better understanding of molecular mechanisms of B-CLL trafficking and homing and response to the targeted therapy. These results may help identification, characterization, modeling and targeting important B-CLL signaling pathways.]]></summary_en></project><project>
<id>7502</id><title_hr><![CDATA[Frakcionalni analogni i mješoviti sustavi obrade signala]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6508</user_id><user_firstLast_name>Dražen Jurišić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-4665</code><acronim><![CDATA[FractalAnalogFilters]]></acronim><duration>01.09.2018 - 01.09.2021</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>21276</team_members_id><team_members_names><![CDATA[ Doktorand: Edi Emanović ]]></team_members_names><keywords_hr><![CDATA[Analogni i mješoviti krugovi, Aktivni električni filtri, Analogno sučelje, Cadence, PSpice]]></keywords_hr><keywords_en><![CDATA[Analog and mixed circuits, Active electrical filters, Analog front end,  Cadence, PSpice]]></keywords_en><summary_hr><![CDATA[U predloženom projektu će se istraživati nove metode projektiranja vremenski kontinuiranih aktivnih analognih filtara necjelobrojnog (frakcionalnog) reda za analogno sučelje u komunikacijskim sustavima. Do sada su takvi sustavi bili cjelobrojnog reda, a u ovom projektu će se izvršiti poopćavanje na necjelobrojni red. U najnovijim publikacijama dokazano je da su takve metode poželjne, ali u mnogim primjenama postoje ograničenja zbog izvedivosti frakcionalnih komponenata koji nisu još u komercijalnoj uporabi. Osim problema u proizvodnji frakcionalnih komponenata postoje i neriješeni matematički problemi kao što su analiza osjetljivosti, šuma, te stabilnosti necjelobrojnih sustava. U integriranoj realizaciji se ti problemi posebno uočavaju (visoke osjetljivosti na tolerancije komponenata, nestabilnost zbog parazita) i pozivaju na nove, nekonvencionalne i kreativne tehnike realizacije. Posebno ćemo se u istraživanju usredotočiti na analogni dio mješovitih elektroničkih sklopova, kao dio &#39;analognog sučelja&#39; prema vanjskom analognom svijetu. Pokazati ćemo da se primjenom teorije električnih krugova i linija mogu postići razna predložena poboljšanja. Istraživanja u početku će biti cjelobrojna, a zatim ćemo se koristiti frakcionalnim računom kako bi dobili što veću fleksibilnost i dodatni stupanj slobode u projektiranju. Pomoću teorije fraktala predložiti ćemo novu Besselovu filtarsku aproksimaciju. Kao rezultat projekta, uz navedena nova teoretska dostignuća, dva integrirana kruga koja služe za verifikaciju teorije, realizirat će se u tipičnoj CMOS 0,18um ili 0,35um tehnologiji za koju imamo podršku na FER-u. Ovaj projekt je važan jer unaprjeđuje analogne električne filtre, koji su kasnili u razvoju. Projekt također nudi mogućnost znanstvenog usavršavanja mladih znanstvenika u Hrvatskoj, jer su doktorski studenti i postdoktorski istraživači predviđeni kao suradnici na projektu.  Također je primjenjiv u industriji.]]></summary_hr><summary_en><![CDATA[The proposed project will explore new methods for design of continuous time analog filters of non-integer (fractional) order for analog interface in communication systems. Until now, such systems were of integer order, and in this project the generalization to the non-integer order will be done. In recent publications it has been proven that such methods are desirable, but in many applications, there are limitations due to the feasibility of fractional components that are not yet in commercial use. In addition to the problems in the production of fractional components there are unsolved mathematical problems such as sensitivity analysis, noise and stability of non-integer systems. In the integrated implementation these problems are especially observed (high sensitivity to components tolerances, instability due to parasitic components) and are calling for new, unconventional and creative techniques of realization. In particular we will focus our research on analog part of mixed electronic circuits, which is a part of the &#39;analog interface&#39; to the outside analog world. We will show that the application of the theory of electrical circuits and lines can achieve a variety of proposed improvements. Research in the beginning will be of integer order, and afterwards fractional for high flexibility and additional degree of design freedom. Using the theory of fractals we propose a new Bessel filter approximation. As a result of the project, with new theoretical achievements, two integrated circuits that are used for verification of the theory will be realized in a typical CMOS 0,18um or 0,35um technology for which we have the support of the FER. This project is important because it improves the analog electrical filters that were late in development. The project also offers the possibility of training young scientists in Croatia, because they are predicted as collaborators on this project as doctoral students and postdoctoral researchers. It is applicable for industry, too.]]></summary_en></project><project>
<id>7503</id><title_hr><![CDATA[Geokemija i zapis redoks indikatora u različitim uvjetima okoliša: prema boljem razumijevanju redoks uvjeta u prošlosti]]></title_hr><title_en><![CDATA[Geochemistry and redox proxie’s signature under the diverse environmental conditions: towards better understanding of the past redox]]></title_en><user_id>561</user_id><user_firstLast_name>Elvira Bura-Nakić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-7813</code><acronim><![CDATA[REDOX]]></acronim><duration>01.11.2018 - 31.10.2022</duration><status>Završio</status><financ_value>131.395,58 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Geologija, Kemija, </scie_field_hr><scie_field_en>Geology, Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>23754, 12557, 989, 595, 28632, 864978, </team_members_id><team_members_names><![CDATA[Morten Andersen, Dario Omanović, Nevenka Mikac, Dijana Jadreško, Lucija Knežević, Igor Živković, ]]></team_members_names><keywords_hr><![CDATA[redoks prošlost, pokazatelj, izotopi, koncentracija, redoks vrste]]></keywords_hr><keywords_en><![CDATA[redox history, proxie&#39;s, isotopes, abundance, redox species]]></keywords_en><summary_hr><![CDATA[Rekonstrukcija kemijskog sastava atmosfere i oceana tijekom duge Zemljine geološke povijesti, kao i karakterizacija redoks uvjeta atmosfere i oceana, odnedavna privlači veliku pozornost. Oceanski sedimenti sadržavaju geokemijske zapise kroz veći dio Zemljine povijesti. Istraživanja su pokazala da faktor obogaćenja metala osjetljivih na redoks uvjete, kao i njihov izotopni sastav u (anoksičnim) sedimentima, nose važne informacije o redoks uvjetima u vremenu taloženja sedimenta. Ipak kako bi se u potpunosti iskoristile mogućnosti koje pružaju različiti pokazatelji za rekonstrukciju Zemljine redoks prošlosti obligatorno je temeljito razumijevanje ponašanja istih u suvremenim okolišima.Cilj REDOX-a je daljnja karakterizacija ponašanja prethodno istraživanih pokazatelja (Mo i U), te detaljno istraživanje relativno novih redoks pokazatelja kao što su V i Re. Kombinacija tih pokazatelja pružiti će poboljšani radni okvir nužan za što bolje tumačenje prošlih redoks uvjeta kao i za razdvajanje općih zapisa od zapisa uslijed procesa ograničenih unutar sedimenta.Istraživanja unutar projekta REDOX usmjerena su na:i.) unapređenje primjene skupne Mo-U koncentracije i izotopnih sastava kao redoks pokazatelja;ii.) razvijanje/implementacija specifičnih analitičkih postupaka za određivanje V redoks vrsta i Re izdvajanje i koncentriranje;iii.) definiranje procesa koji kontroliraju Re i V koncentraciju i mobilnost u sedimentu i vodenoj fazi u oksičnim, hipoksičnim i anoksičnim sredinama.Istraživanje unutar REDOX-a ima za cilj kombinirati specifične analitičke pristupe (kromatografsko određivanje V redoks vrsta, izolacija i koncentriranje Re), klasične analitičke tehnike (spektrofotometrija, MC-ICP-MS i elektrokemija) kao i specifičnosti jedinstvenih anoksičinih okoliša uz istočnu obalu Jadrana. Očekuje se da će istraživanja u okviru REDOX-a imati veliki utjecaj u području geokemije i izotopne geokemije metala osjetljivih na redoks (Mo, U, V i Re) unutar modernih i drevnih okruženja.]]></summary_hr><summary_en><![CDATA[Reconstructing the chemistry of past Earth’s atmosphere and ocean, and their redox states, has gained enormous attention recently. Ocean sediments provide geochemical records through much of Earth’s history. The enrichment of several redox-sensitive trace elements, as well as their isotopic composition in (anoxic) sediments have previously shown to carry important information about the prevailing redox conditions at the time of sediment deposition. Yet, to fully capitalize potential of these emerging redox proxies in reconstructing Earths’ past oxygenation state, a thorough understanding proxies geochemistry in modern environments is mandatory.   We aim to further characterise the redox chemistry on proxies which already have some maturity (Mo and U) as well targeting the newly emerging proxies such are V and Re. Combining these proxies will provide an improved framework for interpreting the specific past redox conditions and separate global ocean signatures from localised effects in the sediments. The research within project REDOX will target following subjects:i.) improve the usage of coupled Mo-U abundance and isotopic composition as redox proxy;ii.) development/implementation of specific analytical procedures for determining V redox speciation and Re concentration;iii.) determine the processes controlling Re and V abundance and mobility in sediments and overlying waters spanning oxic, hypoxic and anoxic conditions.The research within REDOX aims to combine particular analytical procedures (chromatographic redox V speciation, Re pre-concentration) with the several others classical analytical techniques (spectrophotometry, MC-ICP-MS and electrochemistry) and the unique study sites along the eastern Adriatic Coast. The research within REDOX is expected to have high impact in the field of environmental and isotope geochemistry, and will significantly contribute to our fundamental understanding of Mo, U, V and Re geochemistry within modern and ancient environments.]]></summary_en></project><project>
<id>7506</id><title_hr><![CDATA[Zaštitni mehanizmi i učinci flavonoida ugrađenih u nanonosače u modelnim membranama i neuronima]]></title_hr><title_en><![CDATA[]]></title_en><user_id>423</user_id><user_firstLast_name>Suzana Šegota</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-8752</code><acronim><![CDATA[NanoFlavNeuroProtect]]></acronim><duration>01.09.2018 - 31.12.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>25279</team_members_id><team_members_names><![CDATA[ Doktorand: Anja Sadžak ]]></team_members_names><keywords_hr><![CDATA[mikroskopija atomskih sila, modelne membrane, flavonoidi, nanočestice, neuroni, oksidativni stres, neurozaštita]]></keywords_hr><keywords_en><![CDATA[atomic force microscopy, model membranes, flavonoids, nanoparticles, neurons,  oxidative stress, neuroprotection]]></keywords_en><summary_hr><![CDATA[Flavonoidi, polifenolne biomolekule s antioksidativnom aktivnošću prepoznate su kao potencijalno novi terapeutici neurodegenerativnih bolesti. Osim što mehanizam antioksidativnog učinka flavonoida do danas nije u potpunosti razjašnjen, mogućnosti njihove terapeutske primjene smanjuje i slaba topljivost u vodi te kemijska nestabilnost pri fiziološkim uvjetima, koja se javlja prilikom primjene farmaceutskih proizvoda. Moguće rješenje je ugradnja flavonoida u nanočestice (NČ) kao nosače. Cilj predloženog projekta je riješiti problem slabe topljivosti u vodi i kemijske nestabilnosti dostavom flavonoida ugrađenih u NČ do modelnih membrana i neurona, čime bi se trebali poboljšati njihovi zaštitni učinci. Kako bi potvrdili primjenjivost ovog pristupa, u sklopu predloženog projekta istražit će se i interakcije između NČ i stanica, posebice membrana i NČ, jer su one od iznimne važnosti za unos u stanice i nanotoksičnost.Kao nano-nosači flavonoida koristit će se dvije vrste biorazgradivih mezoporoznih NČ, silike i getita. Mezoporozne magnetske Fe3O4 NČ su odabrane kao kontrolne NČ zbog dokazanih superiornih svojstava ugradnje i otpuštanja lijekova. Kombinacijom komplementarnih eksperimentalnih tehnika, koja do sada nije u potpunosti iskorištena u području nanobiotehnologije (mikroskopija atomskih sila, spektroskopija sila, infracrvena spektroskopija s oslabljenom totalnom refleksijom, dinamičko raspršenje svijetlosti, mikrokalorimetrija), predloženi projekt će u konačnici omogućiti detaljne informacije o utjecaju veličine, oblika, naboja i hidrofobnosti NČ s ugrađenim flavonoidima na modelne membrane i neurone, posebice u uvjetima oksidativnog stresa. Također, informacije o naboju te promjeni strukturnih i nanomehaničkih svojstava modelnih odnosno neuronskih membrana će omogućiti razvoj novih, poboljšanih terapeutika za neurološke poremećaje izazvane oksidativnim stresom.]]></summary_hr><summary_en><![CDATA[Flavonoids, polyphenolic biomolecules with antioxidative activity, have recently emerged as potential novel therapeutics for neurodegenerative diseases. In addition to the fact that the mechanisms of their antioxidant effects have not yet been fully elucidated, their applicability is rendered by poor water solubility and chemical instability under physiological conditions encountered during pharmaceutical product consumption. Flavonoid incorporation in nanoparticles (NPs) as carriers has been proposed as possible solution to surpass these obstacles. Therefore, the aim of the proposed project is to overcome the problem of poor water solubility and chemical instability of flavonoids by delivering them loaded in NPs to model membranes and neurons whereby their protective effects should be enhanced. In order to confirm usefulness of this approach, interactions between NPs and cells, in particular, membrane-NP interactions, will be determined since they are of crucial importance both for cell uptake and nanotoxicity.Two kinds of biodegradable mesoporous NPs, silica and goethite, will be investigated as flavonoid nanocarriers. Fe3O4 NPs were chosen as control due to their superior drug-loading and controlled release properties. By applying combination of complementary experimental techniques not yet fully exploited in the field of nanobiotechnology (atomic force microscopy, force spectroscopy, infrared spectroscopy with attenuated total reflection, dynamic light scattering, microcalorimetry), this project will ultimately generate detailed knowledge about the effects of the size, shape, charge and hydrophobicity of NPs loaded with flavonoids on model membranes and neurons, especially under oxidative stress conditions. In addition, information about the changes in structural and nanomechanical properties of model and neuronal membranes will pave the way towards development of novel and improved therapeutic solutions for oxidative stress-associated neurological disorders.]]></summary_en></project><project>
<id>7514</id><title_hr><![CDATA[Zdravstvene, kulturne i biološke odrednice dugovječnosti: antropološka studija preživljenja u dubokoj starosti]]></title_hr><title_en><![CDATA[Health, Cultural, and Biological Determinants of Longevity: Anthropological Perspective on Survival in Very Old Age]]></title_en><user_id>12597</user_id><user_firstLast_name>Tatjana Škarić-Jurić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-2497</code><acronim><![CDATA[HECUBA]]></acronim><duration>15.10.2018 - 01.03.2023</duration><status>Završio</status><financ_value>132.623,27 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo, Humanističke znanosti, Društvene znanosti, Prirodne znanosti, Biotehničke znanosti, </scie_area_hr><scie_area_en>Biomedicine and health sciences, Humanities, Social sciences, Natural sciences, Biotechnical sciences, </scie_area_en><scie_field_hr>Javno zdravstvo i zdravstvena zaštita, Biologija, Psihologija, Demografija, Etnologija i antropologija, </scie_field_hr><scie_field_en>Public health and health services, Biology, Psychology, Demography, Ethnology and anthropology, </scie_field_en><institution_hr><![CDATA[Institut za antropologiju]]></institution_hr><institution_en><![CDATA[Institute for Anthropological Research]]></institution_en><team_members_id>12594, 828, 23190, 13712, 23990, 23483, 23466, 4093, 29632, 28871, </team_members_id><team_members_names><![CDATA[Nina Smolej Narančić, Ana Perinić Lewis, Luka Bočkor, Jasminka Despot Lučanin, Spomenka Tomek-Roksandić, Tanja Ćorić, Hrvojka Marija Zeljko, Šime Smolić, Maja Šetinc, Željka Celinšćak, ]]></team_members_names><keywords_hr><![CDATA[starenje, dugovječnost, funkcionalna sposobnost, zdravlje, kultura, biologija]]></keywords_hr><keywords_en><![CDATA[ageing, longevity, functional ability, health, culture, biology]]></keywords_en><summary_hr><![CDATA[Osobe duboke starosti ogledan su primjer uspješnog starenja. Stoga je 2007. - 2009. provedeno antropološko istraživanje u zagrebačkim domovima za starije i nemoćne osobe u sklopu kojeg je za 300 osoba starih 85 i više godina prikupljen širok spektar podataka (anketni, biometrijski, DNA uzorci) koji čine polazište predloženog istraživanja. Protok vremena od 10 godina od inicijalnog istraživanja daje prvorazrednu mogućnost utvrđivanja dvaju ključnih ishoda: duljine života ispitanika (te izdvajanje poduzorka uistinu dugovječnih osoba) i duljine razdoblja njihove funkcionalne sposobnosti. Obje vrste ishoda predstavljaju krajnje točke prema kojima se mogu ocjenjivati sve mjerene značajke ispitanika te detektirati one koje obilježavaju uspješno starenje. Cilj je predloženog istraživanja da sveobuhvatno istraži utjecaj ne samo pojedinih bioloških odrednica i zdravstvenog stanja, već i socioekonomskih i psiholoških odlika kao i utjecaja osobne povijesti te čimbenika kulture (stavova, ponašanja, navika) na dinamiku procesa starenja. U sklopu projekta dodatno će se izvršiti genotipizacija „gena dugovječnosti“ i duljine telomera te regrutirati uzorak mladih odraslih osoba za komparativne genetičke analize. Utvrdit će se i učestalost rizičnih varijanti farmakogenetički relevantnih ADME gena koje mogu dovesti do štetnih djelovanja pri uzimanju pojedinih lijekova, što s obzirom na polipragmaziju prisutnu u ovoj dobnoj skupini predstavlja specifičan praktični doprinos projekta. Istraživanje povezanosti dvaju ključnih ishoda s biološkim, zdravstvenim i sociokulturnim obilježjima provest će multidisciplinarni tim stručnjaka iz različitih znanstvenih područja (medicina, biologija, antropologija, psihologija, ekonomija). Očekuje se da predloženo istraživanje fenomena dugovječnosti doprinese suvremenim teorijama starenja, ali i da ono urodi rezultatima koji bi mogli imati implikacije za gerontološku i gerijatrijsku praksu te za planiranje javnozdravstvenih i socijalnih politika u RH.]]></summary_hr><summary_en><![CDATA[Persons of very old age may be a particularly useful model for successful ageing. Within the extensive anthropological survey of 300 oldest old persons (85+ yrs) conducted in 2007/09 in retirement homes in Zagreb, a wide spectrum of data from face-to-face interviews, biometry and blood samples was collected that forms the basis for proposed research. The period of 10 years that elapsed since this initial study offers now a first class possibility to detect the two key outcomes: the examinees&#39; survival time (and selection of exceptionally long-lived subsample) and the duration of their preserved functional ability. Both outcomes represent the endpoints according to which all studied traits will be assessed in order to elucidate those that have a crucial role in successful ageing. While most studies have focused on particular aspects of human longevity, the proposed project aims at investigating comprehensively the impact of numerous biological and health-related features along with different socioeconomic and psychological traits as well as life history and cultural factors (attitudes, behavior, habits). Additional data will be generated through genotyping of „longevity genes“ and telomeres’ length in long-lived and in newly recruited comparative sample of young persons. Also, genotyping of the pharmacogenetically relevant ADME genes will be performed in order to determine the frequency of their risk variants for adverse reactions to drugs which is of high practical importance due to the existing polypragmasy in advanced age. To achieve the aims of the project, a multidisciplinary team of investigators from the fields of anthropology, medicine, biology, psychology and economy has been set up. The proposed investigation of successful ageing and longevity is expected to contribute to the current theories of ageing and to bring results relevant for gerontological and geriatric practice and for planning the public health and social policies in the Republic of Croatia.]]></summary_en></project><project>
<id>7515</id><title_hr><![CDATA[Analiza interakcija butirilkolinesteraze s novim inhibitorima i reaktivatorima ]]></title_hr><title_en><![CDATA[Analysis of Butyrylcholinesterase Interactions with Novel Inhibitors and Reactivators]]></title_en><user_id>872</user_id><user_firstLast_name>Zrinka Kovarik</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-7683</code><acronim><![CDATA[AnalyseBChE]]></acronim><duration>01.10.2018 - 30.09.2022</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut za medicinska istraživanja i medicinu rada]]></institution_hr><institution_en><![CDATA[Institute for Medical Research and Occupational Health]]></institution_en><team_members_id>991, 411, 489, 3241, 982, 3033, 5926, 24011, 28637, 28972, 17747, </team_members_id><team_members_names><![CDATA[Anita Bosak, Nikolina  Maček Hrvat, Goran Šinko, Anamarija Knežević, Maja Katalinić, Suzana Žunec, ZORAN RADIC RADIC, Vesna Gabelica Marković, Tena Cadez Cadez, Ana Matošević, Tamara Zorbaz, ]]></team_members_names><keywords_hr><![CDATA[acetilkolinesteraza, butirilkolinesteraza, bojni otrovi, inačice, kinetika]]></keywords_hr><keywords_en><![CDATA[acetylcholinesterase, butyrylcholinesterase, bioscavengers, variants, nerve agents, kinetics]]></keywords_en><summary_hr><![CDATA[Inhibicija ljudske butirilkolinesteraze (BChE) vezanjem spojeva na katalitički serin ima iznimnu ulogu u detoksikaciji i zaštiti organizma od ksenobiotika kao što su organofosfati (OP) te u metabolizmu lijekova kao što su karbamat bambuterol i fenotiazin etopropazin. Međutim, unatoč ovoj važnoj ulozi BChE, proučavanje kinetike tog enzima uglavnom je vezano uz istraživanje srodnog enzima acetilkolinesteraze (AChE) ključne za prijenos živčanih impulsa. Štoviše, reaktivatori inhibirane BChE, kao i lijekovi koji se koriste za liječenje neurodegenerativnih bolesti, sintetizirani su empirijski prije razriješenja kristalne strukture enzima. Zbog specifičnosti aktivnog mjesta BChE afinitet enzima te inhibicija i brzina reaktivacije nisu do sada detaljno istražene. Isto tako naša istraživanja ukazuju da na brzinu reakcije reaktivacije značajno utječe dizajn eksperimenta te reakcije poput oksimolize i reverzibilne inhibicije, kao i adekvatna razrjeđenja u Ellmanovoj metodi potrebna za zaustavljanje ovih reakcija. Stoga je cilj ovog projekta detaljno istražiti mehanizme interakcija BChE i moguća ograničenja, koristeći cjelovitu analizu dosadašnjih spoznaja te istraživanjem interakcija BChE s poznatim i novim spojevima. Biokemijski mehanizam enzimskih interakcija proučavat će se na molekulskom nivou pomoću in silico, in vitro i ex vivo metoda. Kinetičke konstante ispitivanih reakcija odredit će se na temelju poznatih kinetičkih modela, dok će u slučaju ne standardne regresijse biti razvijeni novi kinetički modeli. Ove složene analize dat će uvid u strukturna svojstva koje neki spoj mora zadovoljiti kako bi ostvario produktivne interakcije s BChE čime će se stvoriti osnove za dizajn i sintezu reaktivatora fosfilirane BChE kao i potencijalnih lijekova za bolesti koje uključuju inhibiciju BChE. Stoga, rezultati ovog projekta će otvoriti nove perspektive, a njihov će utjecaj izaći iz okvira istraživanja kolinesteraza.]]></summary_hr><summary_en><![CDATA[The inhibition of butyrylcholinesterase (BChE) in human tissues by binding of compounds to its active site serine is important for the detoxification and scavenging of xenobiotics such as organophosphates (OP) as well as for the metabolism of pro-drugs and drugs such as the carbamate bambuterol and the phenothiazine ethopropazine. Despite of the importance of BChE, its kinetic reactions were investigated mostly as comparative studies on the related enzyme acetylcholinesterase (AChE), which has a vital function in cholinergic neurotransmission. Moreover, reactivators of inhibited BChE, as well as drugs for the treatment of neurodegenerative diseases were empirically synthesized before the BChE crystal structure was resolved. Due to specific structural requirements, its binding affinity, inhibition and reactivation rates have not been rigorously investigated. It is known from our recent analyses that reactivation rates are influenced by experimental design and assays need to account for side reactions – oximolysis, reversible inhibition, and adequate dilution of reactants. Therefore, this project utilizes known and new compounds to gain a better understanding of the mechanistic basis of cholinesterase family interactions and their limitations. The biochemical mechanism of enzyme interactions will be comprehensively studied on a molecular level with in silico, in vitro, and ex vivo methods. Kinetic constants of the studied interactions will be determined based on known kinetic models, while in need of unusual regression analysis new kinetic models will be developed. These comprehensive analyses will explain structural requirements for compounds interacting with BChE and gain a platform for synthesis of reactivators of inhibited BChE and potentially active drugs in disorders that involve BChE inhibition. Many of the findings that should arise from this project will impact the mechanisms of hydrolytic catalysis, extending beyond the field of cholinesterases.]]></summary_en></project><project>
<id>7516</id><title_hr><![CDATA[Makroekonomski učinci turizma]]></title_hr><title_en><![CDATA[Macroeconomic impact of tourism]]></title_en><user_id>2832</user_id><user_firstLast_name>Ivan Kožić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-2961</code><acronim><![CDATA[MACROTOUR]]></acronim><duration>01.12.2018 - 30.11.2022</duration><status>Završio</status><financ_value>7.536,27 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, </scie_field_hr><scie_field_en>Economy, </scie_field_en><institution_hr><![CDATA[Institut za turizam]]></institution_hr><institution_en><![CDATA[Institute for Tourism in Zagreb]]></institution_en><team_members_id>5218, 4385, 5245, 23294, </team_members_id><team_members_names><![CDATA[Ivan Sever, Petar Sorić, NEVEN IVANDIĆ, Velimir Šonje, ]]></team_members_names><keywords_hr><![CDATA[Makroekonomija, Turizam, BDP, Zaposlenost, Inflacija]]></keywords_hr><keywords_en><![CDATA[Macroeconomics, Tourism, GDP, Employment, Inflation]]></keywords_en><summary_hr><![CDATA[Turizam kao amalgam različitih industrija koje udružene služe zadovoljenju ljudske potrebe za razonodom i rekreacijom ima velik i raznolik i utjecaj na društva u suvremenom svijetu.Stoga je sveobuhvatni cilj ovog projekta sustavno istražiti makroekonomske učinke turizma, odnosno one njihove aspekte koji su još uvijek neadekvatno i nedovoljno istraženi. To podrazumijeva analizu triju makroekonomskih kanala putem kojih turizam utječe na gospodarstvo neke zemlje: (1) veza turizma i BDP-a, zatim (2) veza turizma i zaposlenosti te (3) veza turizma i inflacije.Iako je istraživanje veze turizma i BDP-a u postojećoj literaturi razmjerno izdašno dokumentirano, većina objavljenih radova isključivo je usmjerena na izračun turizmom generiranog BDP-a te ispitivanje veze između turizma i gospodarskog rasta. Prvi glavni cilj projekta je proširiti postojeće spoznaje istraživanjem utjecaja turizma na fluktuacije BDP-a te uz to istražiti u kojoj mjeri je veza turizma i gospodarskog rasta ovisna o društveno-političkom kontekstu.S druge strane mjerenje turizmom generirane zaposlenosti nije ni izdaleka tako opsežno istraženo kao mjerenje turizmom generiranog BDP-a. Stoga je drugi glavni cilj projekta ispitati kritične aspekte turizmom generirane zaposlenosti u slučaju malog, otvorenog gospodarstva poput hrvatskog, koje je u velikoj mjeri ovisno o turizmu te uz to istražiti i utjecaj turističke aktivnosti na cikličku (ne)zaposlenost.Treći glavni cilj projekta je istražiti turizmom inducirane inflatorne pritiske. Temeljna pitanja vezana uz dinamiku i trajanje turizmom inducirane inflacije u postojećoj literaturi još uvijek ostaju neodgovorena. Relevantnost projekta je dvostruka. Rezultati istraživanja bi s jedne strane trebali poslužiti kao sveobuhvatni okvir za daljnji razvoj područja makroekonomike turizma. Dok bi s druge strane mogli poslužiti kao empirijski doprinos budućim pokušajima modeliranja računalnog makroekonomskog modela hrvatskog gospodarstva.]]></summary_hr><summary_en><![CDATA[Tourism is an amalgam of different industries that together serve the human needs for leisure and recreation. As such, tourism is a socially important phenomenon that plays a significant transformative role in modern societies.The scope of this project is to explore the macroeconomic impact of tourism. It involves analysis of three channels through which tourism affects the economy: (1) the tourism-GDP nexus, (2) the tourism-employment nexus, and (3) the tourism-prices nexus.Although the issue of the tourism-GDP nexus is relatively well documented in the literature, most of the publications are focused on the calculation of the tourism-generated GDP and testing the tourism-led growth hypothesis. The first main objective of this project is to explore the impact of the activity of tourism on GDP fluctuation. Also to be explored is how tourism development impacts economic growth according to the political and social contexts.The measurement of employment generated by tourism has by no means been analyzed as plentifully as the measurement of tourism-generated GDP. Another main objective is to investigate the practical issues emerging from the measurement of tourism-generated employment in the case of a small tourism-driven economy. Also to be explored is how the activity of tourism impacts cyclical (un-)employment.The last main objective is to explore the inflationary pressure induced by tourism. The open questions regarding the tourism-prices nexus are related to the nature and dynamics of tourism-induced inflation. Is it a transitory or permanent phenomenon in a country like Croatia whose small open economy is heavily dependent on tourism?The relevance of the project is twofold. The written deliverables could serve as a comprehensive framework for further development of tourism macroeconomics. On the other hand, the research results could serve as empirical inputs in any future attempt at modelling a computable macroeconomic model of the Croatian economy.]]></summary_en></project><project>
<id>7519</id><title_hr><![CDATA[Studija važnosti spinskih međudjelovanja  kao osnova za nove pristupe u istraživanju materijala]]></title_hr><title_en><![CDATA[Elucidating the importance of spin-spin interactions as a tool for new approaches in ESR studies of materials]]></title_en><user_id>510</user_id><user_firstLast_name>Marina Ilakovac Kveder</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-3168</code><acronim><![CDATA[SPES]]></acronim><duration>01.11.2018 - 31.03.2023</duration><status>Završio</status><financ_value>137.932,68 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, Kemija, </scie_field_hr><scie_field_en>Physics, Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>1213, 2647, 3280, 23120, 3545, 8238, 28786, 864926, </team_members_id><team_members_names><![CDATA[Dalibor Merunka, Dijana Žilić, Boris Rakvin, Senada Muratović, Srećko Valić, Miroslav Peric, Jakov Slade, Lucija Vujević, ]]></team_members_names><keywords_hr><![CDATA[dekoherencija spina elektrona, molekulski magneti,rotacijska i translacijska dinamika u tekućinama, ESR, HF-ESR]]></keywords_hr><keywords_en><![CDATA[electron spin decoherence, molecular magnets, rotational and translational dynamics in liquids, ESR, HF-ESR]]></keywords_en><summary_hr><![CDATA[Spin elektrona predstavlja osjetljivu lokalnu probu okoline u kojoj se nalazi te sudjeluje u jakim/slabim magnetskim spregama. Te se sprege mogu detaljno proučavati spektroskopijom elektronske spinske rezonancije (ESR). U okviru ovog projektnog prijedloga primijenit će se tehnička postignuća impulsne ESR instrumentacije te ESR spektrometara koji koriste visoke frekvencije/magnetska polja u svrhu dobivanja novih spoznaja o svojstvima promatranih materijala. Otvorena pitanja, koja su izabrana kao ciljevi istraživanja u ovom projektnom prijedlogu, su: a) kako kontrolirati dekoherenciju elektronskih spinova u krutini gdje odlučujući utjecaj ima dinamika mnoštva nuklearnih spinova. U središtu interesa ovog pitanja je hiperfina interakcija kao uzrok nuklearne spektralne difuzije. Sustavi u kojima dominira ovaj mehanizam raspada fazne memorije elektronskih spinova bit će izabrani kao prikladni eksperimentalni modelni sustavi. Primijenit će se različite tehnike dinamičkog razsprezanja u svrhu spoznaje kako se na fizičko stanje krute matrice (staklasto ili kristalinično) može zaključiti iz mjerenja vremena fazne memorije;b) kako opisati magnetska međudjelovanja i uređenje u kristalnoj strukturi molekulskog magneta (metalo-organske mreže, koordinacijski polimeri, kompleksi prijelaznih metala);c) kako dobiti informaciju o rotacijskoj i translacijskoj dinamici paramagnetskih molekula u tekućinama uzimajući u obzir sve efekte hiperfinog i dipolarnog međudjelovanja te međudjelovanja izmjene na pripadajuće ESR spektre.Te tri netrivijalne teme, koje uključuju proučavanje spinskih međudjelovanja elektrona u amorfnim i kristaliničnim materijalima te tekućinama, imaju za cilj proširenje granica koje imaju postojeći teorijski modeli. Također, očekivani cilj je i da se pravilnom manipulacijom i kontrolom spinskih stanja elektrona u ESR eksperimentu omogući dobivanje što više informacija iz spektralne analize, te, ako je moguće, utječe i na svojstva/dizajn materijala.]]></summary_hr><summary_en><![CDATA[Electron spin represents sensitive local probe of its environment and, thus, experiences strong/weak magnetic couplings. These can be thoroughly studied by electron spin resonance spectroscopy (ESR). In this context technical developments regarding pulsed/high magnetic field ESR spectrometers will be exploited in order to achieve new insight into the properties of the material under investigation. Therefore, within this project proposal several open questions are to be addressed: a) how to control the electron spin decoherence in a solid material when nuclear spin bath dynamics is a determining factor. Here, the hyperfine interaction in terms of nuclear spectral diffusion is in the focus of interest. Experimental model systems in which this channel of electron spin phase memory time decay is dominant will be purposely tailored; b) how to describe magnetic interactions in the crystal structure containing transition metal centres (metal-organic frameworks, coordination polymers);c) how to get information about rotational and translational dynamics of paramagnetic molecules in liquid systems by taking fully into account the effects of hyperfine, exchange, and dipolar interactions on their ESR spectra. These three non-trivial experimental tasks to be performed in amorphous, liquid and crystalline materials aim to extend the current limits of the existing theoretical models of electron spin-spin interactions. The expected goal is to extract as much as possible information from the ESR spectral analyses by proper manipulation of the electron spin states in an ESR experiment and possibly paw the way to influence the properties/design of materials. ]]></summary_en></project><project>
<id>7520</id><title_hr><![CDATA[Hiperfosforilacija, agregacija i transsinaptički prijenos tau proteina u Alzheimerovoj bolesti: analiza likvora i ispitivanje potencijalnih neuroprotektivnih spojeva]]></title_hr><title_en><![CDATA[]]></title_en><user_id>20884</user_id><user_firstLast_name>Mirta Boban</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-9299</code><acronim><![CDATA[ALZTAUPROTECT]]></acronim><duration>01.10.2018 - 31.12.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>25387</team_members_id><team_members_names><![CDATA[ Doktorand: Klara Zubčić ]]></team_members_names><keywords_hr><![CDATA[Alzheimerova bolest, cerebrospinalna tekućina (likvor), ELISA, neurofibrilarna degeneracija, neuroprotektivni spojevi, tau protein, tioflavin S ]]></keywords_hr><keywords_en><![CDATA[Alzheimer&#39;s disease, cerebrospinal fluid, ELISA, neurofibrillary degeneration, neuroprotective compounds, tau protein, thioflavine S]]></keywords_en><summary_hr><![CDATA[Za Alzheimerovu bolest (AB) ne postoji uzročno liječenje jer su brojni dosadašnji pokušaji intervencije temeljeni na amiloidnoj kaskadnoj hipotezi bili neuspješni. Usporedno s napretkom razumijevanja uloge tau proteina u patogenezi AB, metabolizam tau proteina je postao i važan terapijski cilj. Naime, smatra se da je u AB ravnoteža između kinaza i fosfataza tau proteina narušena, što dovodi do njegove hiperfosforilacije. Posljedično se povećava i frakcija tau proteina nevezanih za mikrotubule, pa se hiperfosforilirani tau monomeri vežu jedan za drugoga proizvodeći oligomere. Spajanje tau oligomera dovodi do oblikovanja sparenih uzvojitih filamenata, od kojih se sastoje sve neurofibrilarne promjene za koje je dokumentirano da predstavljaju najraniji neuropatološki događaj (tzv. &#39;&#39;pre-tangle&#39;&#39; stadij) od ključnog značaja za patogenezu AB. Ciljevi našeg projekta su: 1) bolje definirati odnos između bioloških biljega ranih stadija AB: ukupnih i fosforiliranih tau proteina, kao i amiloida ß u cerebrospinalnoj tekućini (likvoru) bolesnika s AD, MCI (blagi spoznajni poremećaj) i kontrolnih ispitanika. Uporabom inovativnog ELISA postupka i modificiranog eseja pomoću tioflavina S, u uzorcima likvora odrediti ćemo omjer između monomera i oligomera (agregata) tau proteina. Ti će novi podatci biti uspoređeni s kliničkim, neuropsihološkim i MRI nalazima; 2) testirati ćemo neke poznate i potencijalno neuroprotektivne spojeve (donepezil, klorgilin, nekoliko različitih flavonoida, te PF9601N i ASS234) na fosforilaciju tau proteina izazvanu okadaičnom kiselinom i nokodazolom u kulturama SH-SY5Y i P19 stanica. Epitope tau proteina fosforilirane na Thr181, Ser199 i Thr231 analizirati ćemo ELISA postupkom, a one na epitopima Thr202, Thr205, Ser396 i Ser404 pomoću westernske razložbe; i 3) istražiti ćemo biokemijski i imunocitokemijski transsinaptičko širenje neurofibrilarne degeneracije i razinu izraženosti tau mRNA nakon injekcije tau oligomera u entorinalnu moždanu koru miša.]]></summary_hr><summary_en><![CDATA[There is no effective treatment for Alzheimer’s disease (AD). As many drugs discovery attempts based on the amyloid cascade hypothesis have not been successful, tau protein has become an increasingly important therapeutic target owing to advances in understanding of its role in AD pathogenesis. In AD, the balance of tau kinase and phosphatase activity is shifted, creating a highly phosphorylated species of tau. This raises the fraction of unbound tau, which is no longer attached to microtubules, allowing for monomeric hyperphosphorylated tau to bind to one another to produce oligomers. Fusion of these oligomeric species leads to the formation of paired helical filaments, the primary constituent of neurofibrillary changes, which have been documented to be an early and pivotal event (so-called „pre-tangle“ stage) in the pathogenesis of AD. Our aims are: 1) to define better the relationship between the early AD biomarkers total and phospho-tau proteins, as well as amyloid ß in cerebrospinal fluid (CSF) of AD, MCI (mild cognitive impairment), and control subjects. By using innovative ELISA and modified thioflavin S binding assay on CSF samples, we will also assess the ratio between monomer and oligomer (aggregated) tau species. These new data will be correlated to clinical, neuropsychological, and MRI findings; 2) to test the effect of several known and potentially neuroprotective compounds (donepezil, clorgyline, several flavonoids, PF9601N and ASS234, among others) on tau phosphorylation induced by okadaic acid and nocodazole in SH-SY5Y and P19 cell cultures. Tau epitopes phosphorylated at Thr181, Ser199 and Thr231 residues will be analyzed by ELISA, while p-tau epitopes at Thr202, Thr205, Ser396 and Ser404 will be analyzed by Western blot; and 3) to investigate biochemically and immunocytochemically the trans-synaptic spreading of neurofibrillary degeneration and tau mRNA expression after the injection of tau oligomers in the mouse entorhinal cortex.]]></summary_en></project><project>
<id>7521</id><title_hr><![CDATA[Ekstrakcije bioaktivnih spojeva iz mediteranskog bilja sa “zelenim otapalima” primjenom visokonaponskog pražnjenja]]></title_hr><title_en><![CDATA[]]></title_en><user_id>469</user_id><user_firstLast_name>Anet Režek Jambrak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-8194</code><acronim><![CDATA[GREENVOLTEX]]></acronim><duration>01.10.2018 - 29.06.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Prehrambena tehnologija, </scie_field_hr><scie_field_en>Food technology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Food Technology and Biotechnology]]></institution_en><team_members_id>25273</team_members_id><team_members_names><![CDATA[ Doktorand: Marinela Nutrizio ]]></team_members_names><keywords_hr><![CDATA[visokonaponsko pražnjenje, plazma, ekstrakcije, zelena otapala, mediteransko bilje]]></keywords_hr><keywords_en><![CDATA[high voltage discharges, plasma, extraction, green solvents, mediteranean herbs]]></keywords_en><summary_hr><![CDATA[Prehrambena industrija intenzivno razvija ne-toplinske tehnike obrade hrane kao što su netoplinske plazme, pulsirajuće električno polje, visoki hidrostatski tlak te ultrazvuk visokog intenziteta. Nove netoplinske tehnike omogućavaju provedbu ekstrakcije bioaktivnih tvari bez primjene organskih otapala pri čemu se kao otapalo može koristiti voda ili neka tzv. “zelena otapala” npr. voda, D-limonen, dimetilkarbonat (DMC), etanol, etil-acetat i dr. Jedna od takvih obećavajućih tehnika je i visokonaponsko električno pražnjenje-plazma. Projektom će se nastojati ostvariti sljedeći ciljevi:C1 Razviti uređaj za generiranje plazme koji se sastoji od generatora plazme i reaktora s različitim konfiguracijama elektroda pri čemu će se koristiti inovativan pristup generiranja visokog napona DC napajanja pomoću moderne solid state tehnologije. C2 Utvrditi će se učinkovitost ekstrakcije bioaktivnih komponenti i eteričnih ulja iz autohtonog mediteranskog bilja (list masline, ružmarin, kadulja, mravinac, timijan, majčina dušica) plazmom uz upotrebu vode i „zelenih„ otapala. C3 Optimizirati će se djelovanje inovativnog uređaja za generiranje plazme tijekom ekstrakcija kako bi dobili što veće iskorištenje postupka.C4 Utvrditi će se biološka aktivnost dobivenih ekstrakata putem analitičkih metoda, te ispitati mogućnost nastajanja eventualnih oksidativnih promjena tijekom postupaka ekstrakcija. C5  Dobiveni ekstrakti će se na odgovarajući način izolirati te stabilizirati primjenom postupaka liofilizacije i/ili inkapsulacije.Predloženo istraživanje doprinijeti će području istraživanja, na način da će biti konstruiran inovativni uređaj za produkciju plazme direktno u tekućinama kojim će se moći provesti brza i učinkovita ekstrakcija bioaktivnih komponenata i eteričnog ulja iz autohtonog mediteranskog bilja. Novom netoplinskom tehnikom ekstrakcije nastojat će se smanjiti vrijeme ekstrakcije, upotreba otapala, onečišćenje okoliša i ukupan energetski utrošak uz istovjetno iskorištenje.]]></summary_hr><summary_en><![CDATA[The food industry is rapidly developing new non-thermal food processing techniques like non-thermal plasma, pulsed electric field, high hydrostatic pressure and high intensity ultrasound. New non-thermal techniques are considered “green” extraction methods for isolation of bioactive compounds, because conventionally used organic solvents for extraction can be replaced by water or other green solvents like D-limonen, dimethylcarbonate (DMC), ethanol, ethyl-acetate etc. High voltage electrical discharge-plasma (HVED) is one of new promising green techniques. The aims of this project will be accomplished and they include:O1 Design and development an equipment for generating plasma which consists of: plasma generator and reactor with different configuration of electrodes. During designing of plasma generator, new innovative approach for generating high voltage DC supply by usage of modern solid state technology will be applied.O2 To established effectiveness of extraction of bioactive compounds and volatile oils from autochthonous Mediterranean herbs (olive leaf, rosemary, sage, oregano, thyme, wild thyme), with plasma by usage of water and green solvents O3 To increase yield of process by optimisation of the operation mode of innovative equipment for generating plasma.O4 Biological activity of obtained extracts will be determined by analytical methods, and investigated the possibility of oxidative changes during extraction processO5 Obtained extracts will be isolated and stabilized by lyophilization and/or encapsulation. This Project proposal will contribute to the research area by constructing a new innovative equipment for liquid plasma which will be useful for quick and efficient extraction of bioactive compounds and volatile oils from leaves of autochthonous Mediterranean herbs. By new, non-thermal extraction technique, the attempt is to reduce duration of extraction, solvent usage, environment pollution and total energy consumption.]]></summary_en></project><project>
<id>7523</id><title_hr><![CDATA[Nove Strategije Za Pripravu Tetrasupstituiranih Kiralnih Centara: Asimetrične Katalitičke Reakcije Usmjerene Protuanionom]]></title_hr><title_en><![CDATA[New Strategies for the Synthesis of Tetrasubstituted Chiral Centers: Asymmetric Counteranion-Directed Catalysis]]></title_en><user_id>558</user_id><user_firstLast_name>Matija Gredičak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-4053</code><acronim><![CDATA[NSYNC-ACDC]]></acronim><duration>01.10.2018 - 31.12.2022</duration><status>Završio</status><financ_value>132.284,82 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>22528, 23628, 23654, 27441, 855382, 25282, </team_members_id><team_members_names><![CDATA[Danijel Glavač, Shu-Li You, Chao Zheng, Arben Beriša, Nikola Topolovcan, Mateja Matišić, ]]></team_members_names><keywords_hr><![CDATA[ACDC, organska sinteza, asimetrična organokataliza, kiralne Bronstedove kiseline, tetrasupstituirani kiralni centri]]></keywords_hr><keywords_en><![CDATA[ACDC, organic synthesis, asymmetric organocatalysis, chiral Bronsted acids, tetrasubstituted chiral centers]]></keywords_en><summary_hr><![CDATA[Jedan od primarnih zadataka sintetske organske kemije je razvoj kemijskih reakcija koje na kontrolirani način selektivno omogućuju molekulsku raznolikost. Stoga je od velikog značaja razvoj novih metoda za visoko selektivne i specifične priprave složenih spojeva. Prilikom razvoja takvih metoda, jedan od najvećih izazova kemičarima predstavlja priprava kiralnih tetrasupstituiranih stereogenih centara. Iako je moderna sintetska kemija opremila kemičare nizom metoda za savladavanje najsloženijih sintetskih problema, takvi su protokoli često skupi i vremenski zahtjevni. S druge strane, Priroda takve procese obavlja s lakoćom upotrebom enzima – složenih strojeva usavršavanih milijunima godina evolucije. Cilj ovog projekta je razvoj istraživačkog programa za oponašanje Prirode i enzima korištenjem asimetričnih organokatalitičkih reakcija, s ciljem kontroliranja selektivnog i specifičnog nastajanja složenih struktura koji u sebi sadrže tetrasupstituirane stereogene centre kao aktivne strukturne podjedinice.Nastajanje novih kemijskih veza temeljit će se na strategiji ionskih parova, konceptu koji je već primjenjen u seriji asimetričnih transformacija, no koji je ograničen relativno niskom aktivacijom početnih spojeva. Kako bi se omogućila aktivacija takvih sustava, projektom se predlaže proširenje koncepta ionskih parova na asimetrične katalitičke reakcije usmjerene protuanionom (eng. asymmetric counteranion-directed catalysis, ACDC). Na taj bi se način omogućila priprava složenih strukturnih kostura koji se trenutno mogu dobiti isključivo primjenom zahtjevnih, skupih i nepraktičnih protokola. Projektom se predviđa razvoj asimetričnih metoda za pripravu tetrasupstituiranih stereogenih centara korištenjem ACDC strategije, s posljedičnim ciljem razvoja učinkovitije katalize nekovalentnim interakcijama. Projekt pruža mogućnost za istraživanje i primjenu čitavog niza katalitičkih asimetričnih organskih reakcija za koje trenutno ne postoji presedan.     ]]></summary_hr><summary_en><![CDATA[One of the primary goals of synthetic organic chemistry is the development of chemical reactions that selectively introduce molecular diversity in a controlled manner. In this regard, the development of novel methods for highly selective and specific syntheses of complex materials is of great importance. In the development of these novel methods, one of the biggest challenges presented to chemists is the construction of tetrasubstituted stereogenic centers. Although modern chemistry offers access to a plethora of tools to tackle the most complex total syntheses, these processes are expensive and time consuming. On the other hand, Nature effortlessly performs these tasks by employing enzymes – complex machines perfected through millions of years of evolution.In this proposal, we aim to emulate Nature through asymmetric catalysis in order to develop selective and specific protocols for the construction of complex materials comprising tetrasubstituted stereogenic centres as active structural subunits. We plan to base our new strategic bond forming reactions on ion pairing strategy. This principle has already been exploited in the range of elegant selective asymmetric transformations, but can be limited by relatively low levels of activation offered by these materials. In order to achieve activation of such systems, we plan to extend the principle of ion–binding in catalysis by employing asymmetric counteranion–directed catalysis (ACDC). This is an important task as it will allow formation of demandingstructural motifs that are currently difficult to produce. This proposal aims to develop transformations for the generation of complex materials with chiral tetrasubstituted centers by employing ACDC strategies, and lead to the development of more efficient catalyst systems that operate through non–covalent interactions. The project offers a rare opportunity to investigate and exploit an entire manifold of unprecedented catalytic asymmetric organic reactions.]]></summary_en></project><project>
<id>7531</id><title_hr><![CDATA[Reprogramiranje homeostaze i regeneracije kože uporabom nove tehnike mikro-transplantacije stanica]]></title_hr><title_en><![CDATA[Reprogramming of skin homeostasis and regeneration using a novel cell micro-transplantation technology]]></title_en><user_id>1396</user_id><user_firstLast_name>Ivica Rubelj</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-8654</code><acronim><![CDATA[REPROSKIN]]></acronim><duration>17.12.2018 - 23.04.2023</duration><status>Završio</status><financ_value>132.059,19 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>19039, 3333, 570, 6719, 23714, 23744, 27530, 1137, </team_members_id><team_members_names><![CDATA[Lucia Nanić, Marija Mary Sopta, Miljenko Huzak, Sanja Davidović-Mrsić, Michael Bader, Florian Gruber, Andrea Cedilak, Vladimir Farkaš, ]]></team_members_names><keywords_hr><![CDATA[starenje, regeneracija, starenje kože, mikro-transplantacija, tkivna homeostaza, SASP]]></keywords_hr><keywords_en><![CDATA[aging, regeneration, skin aging, micro-transplantation, tissue homeostasis, SASP]]></keywords_en><summary_hr><![CDATA[Nakupljanje starih stanica u tkivima je glavni katalizator starenja kod ljudi. Stare stanice imaju promijenjenu ekspresiju gena, karakteriziranu porastom sekrecije citokina, kemokina i ekstracelularnih proteinaza, poznatih kao senescence-associated secretory phenotype (SASP). SASP negativno utječe na homeostazu kože i epidermalne matične stanice (ESC). Ekspresija enzima telomeraze sprječava starenje stanica i održava njihov mladi fenotip. U ovom projektu ćemo istražiti mogučnost za regeneraciju i pomlađivanje kože pomoću tehnike mikrotransplantacije stanica. Analizirat ćemo promjene u koži nakon povečanja udjela mladih ili pomlađenih zdravih stanica na modelu štakora te na modelu ljudskih organotipskih epidermalnih kultura. To će se postići značajnim povečanjem postotka (> 35%, do 55%) mladih stanica ili telomerazom revitaliziranih stanica u koži. Očekujemo da će doći do povećanja regenerativne sposobnosti dermisa i epidermisa, kao i povećanja aktivnosti epidermalnih matičnih stanica. Osim starenja, različiti genetski poremećaji mogu poremetiti zaštitnu funkciju kože. Među najtežim takvim poremećajima je Epidermoliza bullosa (EB). EB je heterogena skupina nasljednih poremećaja kože uzrokovanih mutacijama u 18 različitih gena važnih za dermalno-epidermalne veze, među kojima je i kolagen VII (C7) koji učvršćuje bazalnu membranu. Štakori koji nose takve mutacije imaju krhku kožu sklonu guljenju koja ujedno pokazuje sve glavne karakteristike EB kod ljudi. Stoga ćemo također analizirati promjene u koži EB štakora nakon povećanja udjela stanica koje nose divlji tip C7. Do sada smo uspostavili protokol za mikrotransplantaciju stanica u tkivo kože koji nam omogućuje manipulaciju raznim staničnim tipovima. Glavni cilj ovog projekta je izravno pokazati da je moguće mijenjati stanični sastav kože i time utjecati na metabolički profil lokalnog tkiva, poboljšati aktivnost matičnih stanica in vivo te time povećati regeneraciju kože.]]></summary_hr><summary_en><![CDATA[Accumulation of senescent cells in tissues is the main catalyst of aging in humans. Old cells have altered gene expression, highlighted by a strong increase in secreted cytokines, chemokines and extracellular proteinases known as the senescence-associated secretory phenotype (SASP) which has a negative impact on skin and epidermal stem cells (ESC). Expression of the enzyme telomerase prevents cell aging and maintains their young phenotype. In this project we will explore the potential for skin regeneration and rejuvenation by using a cell micro-seeding technique. We will analyse changes in the skin following an increase in proportion of young or rejuvenated healthy cells in a rat skin model and in human organotypic epidermal equivalent model. This will be achieved by introducing a large proportion (>35%, up to 55%) of young cells or telomerase revitalized cells into skin. We expect to observe increase in regenerative capacity of dermis and epidermis as well as increase in ESC viability. Besides aging, various genetic disorders can disrupt protective function of the skin. Among most severe of such disorders is Epidermolysis bullosa (EB). EB is a heterogeneous group of hereditary skin fragility disorders caused by mutations in 18 different genes important for dermal-epidermal connections, among which is Collagen VII (C7) that anchor the basal membrane. Affected animals have fragile and blister-prone skin showing all major signs of EB in humans. Therefore we will also analyse changes in the EB rat skin following an increase in proportion of cells carrying wild type C7. So far we have established a protocol for micro-transplantation of cells into skin tissue which allows for manipulation of various cell populations. The main objective of this project is to directly show that it is possible to alter the cellular composition of tissues and with that alter the local tissue metabolic profile, improve viability of ESC in vivo and increase skin healing and regeneration.]]></summary_en></project><project>
<id>7538</id><title_hr><![CDATA[Hlađenje atoma frekventnim češljem]]></title_hr><title_en><![CDATA[Frequency comb cooling of atoms]]></title_en><user_id>5029</user_id><user_firstLast_name>Damir Aumiler</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-9047</code><acronim><![CDATA[CoolComb]]></acronim><duration>01.11.2018 - 31.07.2023</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut za fiziku]]></institution_hr><institution_en><![CDATA[Institute of Physics in Zagreb]]></institution_en><team_members_id>23782, 23999, 23973, 22599, 28963, </team_members_id><team_members_names><![CDATA[Bojan Resan, Danijel Buhin, Wesley Campbell, Neven Šantić, Vjekoslav Vulić, ]]></team_members_names><keywords_hr><![CDATA[lasersko hlađenje, hladni atomi, optički frekventni češalj, rubidij, magneto-optička stupica]]></keywords_hr><keywords_en><![CDATA[laser cooling, cold atoms, optical frequency comb, rubidium, magneto-optical trap]]></keywords_en><summary_hr><![CDATA[Uvođenje laserskog hlađenja u atomsku i molekulsku fiziku prije tri desetljeća započelo je revoluciju koja nastavlja redefinirati krajolik eksperimenata koji nam pomažu bolje razumijeti kvantni svijet. Korištenje uskopojasnih kontinuiranih lasera za kontrolu temperature atoma evoluiralo je tijekom godina te postiglo puno šire područje primjene nego što je prvobitno bilo predviđeno, brzo pomičući granice znanstvenog razvoja kroz impresivne pothvate u području ultrahladnih atoma. Ipak, unatoč značajnim napretcima, preostaju važne praznine unutar područja, a jedna od najizraženijih je naša nemogućnost da laserski hladimo i zarobljavamo vodik, (gotovo sve) molekule te najrasprostranjenije atome organske kemije: ugljik, kisik i dušik.Cilj ovog projekta je stvoriti alate koji će nam omogućiti širenje primjene laserskog hlađenja na raznolike vrste atoma i molekula. Konkretno, koristit ćemo optički frekventni češalj za izravno lasersko hlađenje i zarobljavanje atoma rubidija (Rb) te demonstrirati istodobno hlađenje dva Rb izotopa. Kako bi postigli taj cilj, okupili smo iskusan tim istraživača - stručnjake za lasersku fiziku, hladne atome, spektroskopiju frekventnim češljem te teorijsko modeliranje međudjelovanja lasera i atoma - koji će (i) teorijski modelirati radijativnu silu na atome uzrokovanu frekventnim češljem i odrediti optimalne parametre češlja za hlađenje, (ii) dizajnirati i izgraditi novi pikosekundni Ti:safir laser sa spregnutim modovima pumpan plavim diodama, (iii) stabilizirati i postići kontrolu nad spektrom frekventnog češlja lasera te (iv) primijeniti frekventni češalj za izravno hlađenje i zarobljavanje Rb atoma i istodobno hlađenje dvije vrste atoma.Naša uspješna demonstracija potvrdit će frekventni češalj kao novi alat za lasersko hlađenje šireg raspona molekula i atoma koje do sada nije bilo moguće hladiti, omogučujući tako napredak u područjima kao što su kontrolirana kemija, astrofizika, precizna mjerenja te kvantne informacije i simulacije.]]></summary_hr><summary_en><![CDATA[The introduction of laser cooling to atomic and molecular physics three decades ago started a revolution that continues to redefine the landscape of feasible experiments which help us better understand the quantum world. The use of narrow-band continuous-wave lasers to control the motional temperature of atoms has evolved over the years to have much broader applications than originally anticipated, rapidly pushing forward the frontiers of scientific development through impressive efforts in the field of ultracold atoms. Yet despite these substantial advances, there remain important gaps in the field, one of the most conspicuous being our inability to laser cool and trap hydrogen, (almost any) molecules, or the most prevalent atoms in organic chemistry: carbon, oxygen, and nitrogen.The aim of this project is to create the tools that will allow us to extend laser cooling to more diverse species of atoms and molecules. Specifically, we will use an optical frequency comb for direct laser cooling and trapping of rubidium (Rb) atoms, and demonstrate simultaneous comb cooling of two Rb isotopes. To achieve this goal, we have gathered an experienced team of researchers – experts in laser physics, cold atoms, frequency comb spectroscopy, and theoretical modeling of laser-atom interactions – who will (i) theoretically model the comb-induced radiative force on atoms and define optimal comb parameters for cooling, (ii) design and build a novel blue-diode-pumped Ti:sapphire picosecond mode-locked laser, (iii) stabilize and gain control over its frequency comb spectrum, and (iv) apply the comb for direct cooling and trapping of Rb atoms and simultaneous dual-species cooling.Our successful demonstration will validate the frequency comb as a new tool for laser cooling a broader range of molecules and so far un-coolable species thus allowing breakthroughs in fields as diverse as controlled chemistry, astrophysics, precision measurements, and quantum information and simulation.]]></summary_en></project><project>
<id>7539</id><title_hr><![CDATA[Novi biomarkeri kronične bolesti presatka protiv primatelja]]></title_hr><title_en><![CDATA[]]></title_en><user_id>19447</user_id><user_firstLast_name>Dražen Pulanić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-5291</code><acronim><![CDATA[Bio-cGVHD]]></acronim><duration>01.10.2018 - 16.02.2020</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Clinical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>25382</team_members_id><team_members_names><![CDATA[ Doktorand: Antonela Samardžić ]]></team_members_names><keywords_hr><![CDATA[kronična bolest presatka protiv primatelja, biomarkeri, alogena transplantacija krvotvornih matičnih stanica, vWF, faktor VIII, glikani, imunologija]]></keywords_hr><keywords_en><![CDATA[chronic Graft-versus-Host disease, biomarkers, allogeneic hematopoietic stem cell transplantation, vWF, factor VIII, glycans, immunology]]></keywords_en><summary_hr><![CDATA[Kronična bolest presatka protiv primatelja (eng. chronic Graft-versus-Host disease, cGVHD) je multiorganska aloimuna i autoimuna bolest koja je najvažnija kasna komplikacija nakon alogenične presadbe krvotvornih matičnih stanica (aloPKMS) i vodeći uzrok ne-relapsnog morbiditeta i smrtnosti nakon aloPKMS. Zapažena incidencija bolesti kreće se između 30-70% nakon aloPKMS i povećava se zbog sve manjeg peritransplantacijskog mortaliteta, starije dobi transplantiranih bolesnika, češće upotrebe perifernih krvotvornih matičnih stanica i sve većeg broja transplantacija od nesrodnog davatelja. Bolest je kompleksna i obično zahvaća više različitih organskih sustava (kožu, oči, usta, jetru, gastrointestinalni sustav, pluća, muskuloskeletni sustav i genitourinarni sistem), a često se prezentira manifestacijama koje nalikuju na promjene u autoimunosnih bolesti. Nužno je pronalaženje prediktivnih i dijagnostičkih biomarkera koji bi koristili u procjeni rizika nastanka, dijagnoze i praćenja, procjene ativnosti i ishoda kroničnog GVHD. U Kliničkom bolničkom centru Zagreb 2013. godine osnovan je multidisciplinarni tim stručnjaka za cGVHD po uzoru na onaj formiran na National Institutes of Health (NIH, Bethesda, SAD). Osim što doprinosi poboljšanju skrbi za cGVHD pacijente, ovaj tim omogućuje preciznu interdisciplinarnu kliničku i laboratorijsku evaluaciju bolesti, prikupljanje bioloških uzoraka te nudi veliki potencijal za ispitivanje biomarkera ove teške i potencijalno smrtonosne kasne komplikacije nakon aloPKMS.Cilj ovog novog četverogodišnjeg projekta je prospektivnim longitudinalnim istraživanjem ispitati moguće nove biomarkere kroničnog GVHD (analizu glikana, faktora koagulacije, laboratorijskih parametara upale, B limfocita i monocita) uz detaljno kliničko multidisciplinarno evaluiranje bolesnika korištenjem suvremenih NIH standarda za cGVHD. ]]></summary_hr><summary_en><![CDATA[Chronic graft-versus-host disease (cGVHD) is a multi-organ alloimmune and autoimmune disorder and the most important late complication after allogeneic hematopoietic stem cell transplantation (alloHSCT). It is the major cause of non-relapse morbidity and mortality after alloHSCT. Reported incidence rates of cGVHD range from 30-70% of patients after alloHSCT, and are increasing due to lower peritransplant mortality, older recipients, the more frequent use of peripheral blood graft, and more unrelated donors. It is a complex and multisystem disease, affecting skin, eyes, mouth, liver, gastrointestinal tract, lungs,  muscular-skeletal system, and genital tract, often resembling manifestations of various autoimmune diseases. Predictive and diagnostic biomarkers of cGVHD are much needed to predict its onset, diagnose and monitor the disease, prognoses its course and outcome, and characterize its activity. At the University Hospital Center Zagreb a multidisciplinary team for cGVHD was formed in 2013 according to the team from the National Institutes of Health (NIH, Bethesda, USA).  This approach improved care of patients with cGVHD, but also provides interdisciplinary clinical and laboratory evaluation of this disease, collection of biologic samples with great potential for investigation of biomarkers of this complex and potentially lethal late complication after alloHSTC. The goal of this 4-year project is to study possible new biomarkers of cGVHD (glycan analysis, coagulation factors, laboratory markers of inflammation, B lymphocytes and monocytes) in a prospective longitudinal assessment of cGVHD patients, with their detail multidisciplinary evaluations using modern NIH standards for cGVHD.]]></summary_en></project><project>
<id>7543</id><title_hr><![CDATA[Kronične upalne bolesti crijeva u djece: incidencija, tijek bolesti te uloga prehrane i crijevne mikroflore u etiopatogenezi]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5694</user_id><user_firstLast_name>Sanja Kolaček</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-1181</code><acronim><![CDATA[PED-IBD]]></acronim><duration>23.07.2018 - 22.07.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Clinical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>25201</team_members_id><team_members_names><![CDATA[ Doktorand: Ivana Trivić ]]></team_members_names><keywords_hr><![CDATA[upalne bolesti crijeva, djeca, crijevna flora, enteralna prehrana, incidencija, registar]]></keywords_hr><keywords_en><![CDATA[inflammatory bowel disease, children, enteral nutrition, incidence, registry]]></keywords_en><summary_hr><![CDATA[Etiologija i patogeneza kroničnih upalnih bolesti crijeva (IBD - inflammatory bowel disease), unatoč visokoj prevalenciji, nisu razjašnjene. Predloženi mehanizam uključuje interakciju neodgovarajućeg (aberantnog) imunološkog odgovora na crijevnu mikrofloru / crijevni sadržaj, u genetski predisponiranih osoba. Cilj je ovog istraživačkog projekta pridonijeti rasvjetljavanju navedene patogeneze.Ciljevi. 1. Prehrana. Bolesnici s IBD-om vrlo često izbjegavaju određene namirnice u prehrani, pridajući im – po njihovu bolest – neželjena svojstva. Međutim, učinak takvih samonametnutih dijeta nije do sada istražen i za takve dijetetske postupke zasad nema znanstveno utemeljnog opravdanja. Od posebne je to važnosti za djecu u koje ozbiljnije dijetetske restrikcije mogu imati dugoročne posljedice na rast i razvitak. Stoga je prvi cilj ovog projekta utvrditi učestalost samoiniciranih dijeta u djece s IBD-om i procijeniti njihov učinak na: a) nutritivni status koristeći strogo definirane parametre, b) tijek bolesti. U istraživanje će se uključiti novodijagnosticirani bolesnici s IBD-om te zdrave kontrole.2. Crijevna mikroflora. Znanstveno je potvrđena terapijska učinkovitost isključive enteralne prehrane (EEN - exclusive enteral nutrition) na aktivnu formu Crohnove bolesti (CD) u djece, koja se, dijelom, pripisuje utjecaju na crijevnu mikrofloru. Međutim, dokaza o njihovoj povezanosti zasad nema. Stoga je drugi cilj ovog istraživanja utvrditi razliku u crijevnoj mikroflori u trenutku postavljanja dijagnoze i nakon indukcije remisije sa EEN. Crijevna mikroflora bolesnika usporedit će se s crijevnom mikroflorom zdravog brata ili sestre oboljelog djeteta i to neposredno prije, i dva dana nakon početka EEN. Nadalje, u djece s CD crijevna će se mikroflora odrediti i nakon završetka EEN te svakih dva mjeseca tijekom cijele prve godine praćenja. 3. PED-IBD registar. Do sada nije utvrđena incidencija, tijek i ishod bolesti („natural history“) u djece oboljele od IBD-a u Republici Hrvatskoj. Slijedom navedenoga, treći je cilj našeg projekta utemeljiti nacionalni registar djece s IBD-om s on-line bazom podataka koja će sadržavati sve važne kliničke i dijagnostičke parametre u sve djece s novodijagnosticiranom bolesti u Hrvatskoj. Podaci o bolesniku unositi će se kod dijagnoze i nakon godine dana praćenja. Za određivanje rizičnih čimbenika za nastanak relapsa koristit će se multivarijatna analiza koja će uključiti kliničke i terapijske parametre. ]]></summary_hr><summary_en><![CDATA[The etiology and pathogenesis of inflammatory bowel disease (IBD) have not been fully elucidated. 1. Diet. Patients with IBD, despite the absence of scientific evidence, often avoid certain types of food; however the effect of those self-imposed diets has not been determined. This is especially important in children whereby insufficient diet could have long-term consequences on growth and development. Therefore, the first objective of our study is to determine the frequency of self-induced diets in children with IBD and their impact on: a) nutritional status by using clearly defined parameters and b) course of the disease. The study will include newly diagnosed patients with IBD and healthy controls. 2. Intestinal microflora. It has been hypothesized that the excellent therapeutic effect of exclusive enteral nutrition (EEN) on pediatric active Crohn&#39;s disease (CD) could be explained by the effect on intestinal microflora. However, well performed studies are lacking. Therefore, the second objective of our study is to determine the difference in gut microflora at diagnosis and after remission induction achieved with EEN. Patients’ intestinal microflora will be compared with the microflora of healthy siblings before and two days after both groups receive EEN. Furthermore, in children with CD the intestinal microflora will be determined after 6 weeks of EEN and during the first year of follow up.  3. PED-IBD Registry. The incidence and natural history of pediatric IBD in Croatia has not been determined yet. The third goal of our project is to establish a national registry of children with IBD by providing an on-line database that will contain relevant clinical and diagnostic factors on all newly diagnosed pediatric IBD patients. To achieve this goal data will be entered at diagnosis and after one year of follow up. Multivariate analysis, which will include clinical and therapeutic parameters, will be used to determine risk factors for early disease relapse.]]></summary_en></project><project>
<id>7544</id><title_hr><![CDATA[Utjecaj akvakulture na prirodne morske populacije]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3217</user_id><user_firstLast_name>Tanja Šegvić Bubić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-1940</code><acronim><![CDATA[AquaPop]]></acronim><duration>01.08.2018 - 30.04.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Institut za oceanografiju i ribarstvo]]></institution_hr><institution_en><![CDATA[Institute of Oceanography and Fisheries]]></institution_en><team_members_id>21299</team_members_id><team_members_names><![CDATA[ Doktorand: Igor Talijančić ]]></team_members_names><keywords_hr><![CDATA[Akvakultura, utjecaj, prirodne populacije riba i školjkaša, ekološke zamke, prebjezi, genetske interakcije]]></keywords_hr><keywords_en><![CDATA[Aquaculture, Impact, Wild fish and shellfish populations, ecological traps, escapees, genetic interactions]]></keywords_en><summary_hr><![CDATA[Zbog stalnog rasta broja lokacija za uzgoj morskih organizama javlja se sveprisutna zabrinutost da marikultura kao gospodarska djelatnost može predstavljati opasnost za morsku biološku raznolikost kroz negativni utjecaj na prirodne populacije morskih organizama kao i cjelokupni morski ekosustav. Ekološke interakcije se odražavaju kroz činjenicu da kavezne uzgojne instalacije postaju nove ekološke niše za prirodne populacije ribe kod kojih promjene u fiziologiji i ponašanju su moguće. Drugi rizik za okoliš se očituje u mogućem utjecaju zbjegova uzgojne ribe iz kaveza prisutne u morskom okolišu kao rezultat slučajnog bijega iz kaveza ili namjernog poribljavanja. Pobjezi ili poribljavane jedinke iz uzgoja predstavljaju potencijalni rizik genetskoj osnovi izvornih ribljih populacija. Zbog boljeg razumijevanja složenosti  utjecaja akvakulture na prirodne populacije, ovaj projekt će iskoristiti najnovije instrumentalne i genetske pristupe s ciljem podržavanja uzgojnih i upravljačkih aktivnosti, kao i zaštite morskog okoliša. Projekt uključuje: (i) uporabu suvremenog sustava stereoskopske kamere i multivarijatnih analizi indirektnih pokazatelja kondicije s ciljem procjene uloge uzgajališta kao ekoloških zamki divljih ribljih populacija, (ii) korištenje forenzički svojstvenih genetskih alata u procjeni genetske strukture divljih/uzgojnih riba i školjkaša , (iii) uporaba suvremenog genetski-analitičkog pristupa s ciljem određivanja porijekla uzgojnih populacija i utvrđivanja možebitnih genetskih interakcija populacija iz uzgoja s prirodnim/divljim populacijama iste vrste, a na kraju (iv) procjena utjecaja translokacije mlađi kamenica između geografski udaljenih uzgojnih lokacija na genetsku strukturu izvornih populacija kamenice u hrvatskom dijelu Jadrana.Zaključno, predloženi projekt se nadovezuje na zajednički izazov evropske zajednice  koji se očituje u poticanju razvoja održive akvakulture kroz poboljšanje konkurentnosti i ekološki prihvatljive proizvodnje. Kako su potencijalno negativni učinci akvakulture prisutni u svim zemljama EU-a, međunarodna suradnja će se biti prepoznata i implementirana tijekom provedbe projektnih zadataka. Projektni ishodi će biti dostupni svim zainteresiranim strankama odnosno istraživačima, industriji, zakonodavnim tijelima i svim potencijalnim korisnicima.]]></summary_hr><summary_en><![CDATA[Expansion of marine farming sites raised the concern that aquaculture may pose a threat to biodiversity due to detrimental impacts on wild populations and ecosystem. Ecological interactions of farm installations are reflected through  acting as new ecological niches for the local fish where also altered wild fish physiology and behaviour may occur. Another environmental risk is the potential impact of releasing farmed fish into the wild, through accidental escape or deliberate restocking. Escapes or releases of the domesticated aquaculture fish pose a potential risk of adverse effects on native fish gene pools. To better understand the complexity of aquaculture impacts on the native populations, this project will take advantage of cutting edge instrumental and genetic approaches to support aquaculture activity and management, as well as the protection of marine environment. This includes: (i) using novel stereoscopic camera system and multivariable analysis of proxy measure of fitness to asses do farms function as ecological traps for wild fish, (ii) using forensically validated genetic tools to assess genetic structure of wild/farmed fish and shellfish, (iii) using cutting edge genetic analytical approach to trace the origin of farmed fish and to monitor genetic interactions between fish from aquaculture and their wild conspecifics, and finally (iv) validation of the impact of oyster spat translocation between geographically distinct farming locations on genetic structure of native oysters populations in the Croatian part of the Adriatic Sea. Thus, this project addresses the common European challenge to develop sustainable aquaculture through improved competitiveness and environmentally-friendly production. As the potential adverse effects of aquaculture affect all EU countries, international collaboration will be implemented. The outcome of the project will be available to the researchers, the industry, policy makers and the general public.]]></summary_en></project><project>
<id>7547</id><title_hr><![CDATA[Uloga unutarstaničnog života Francisella tularensis u patogenezi eksperimentalne tularemije]]></title_hr><title_en><![CDATA[]]></title_en><user_id>114</user_id><user_firstLast_name>Marina Šantić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-3785</code><acronim><![CDATA[FRANCYCLE]]></acronim><duration>02.07.2018 - 31.12.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Medicine]]></institution_en><team_members_id>25206</team_members_id><team_members_names><![CDATA[ Doktorand: Ina Kelava ]]></team_members_names><keywords_hr><![CDATA[Francisella, FPO, sazrijavanje fagosoma/vakuole, autofagija, in vitro, in vivo]]></keywords_hr><keywords_en><![CDATA[Francisella, FPI, phagosome/vacuole maturation, autophagy, in vitro, in vivo]]></keywords_en><summary_hr><![CDATA[Francisella tularensis je gram-negativna, visoko infektivna, fakultativno unutarstanična bakterija koja uzrokuje tularemiju. Unutarstanični život F. tularensis je jedinstven u odnosu na druge unutarstanične bakterije. Fagosom koji sadrži francizelu (FCP - Francisella containing phagosome) zaustavljen je u fazi kasnog nezakiseljenog endosoma, nakon čega slijedi postupni bakterijski izlazak u citosol. Očito je da Francisella kruži kroz različite unutarstanične odjeljke; FCP i vakuolu koja sadrži francizelu (FCV – Franicisella containing vacuole). Zbog važnosti ovih staničnih odjeljaka u uspostavi i održavanju infekcije, po prvi put ćemo izolirati FCP i FCV iz makrofaga. Ovo je potpuno novi pristup u razumijevanju njihove uloge u unutarstaničnom životu francizela. Nadalje, pretpostavljamo da se značajni dio interakcije sa citosolom domaćina ostvaruje putem autofagije. Moguće je da, u kasnijoj fazi infekcije, Francisella oblikuje oštećenu FCV u autofagnu vakuolu. Brojna su istraživanja usredotočena na dio bakterijskog genoma poznatijem kao Francizela patogeni otok (FPO). Mnoge FPO mutante pokazuju jednoobrazan fenotip karakteriziran nemogućnošću bijega iz fagosoma, izostankom unutarstanične replikacije te gubitkom virulencije in vivo. Želimo dokazati da su FPO proteini (PdpC, IglC, IglI, PdpE i IglG) koji su efektori tipa VI sekrecijskog sustava uključeni u regulaciju procesa autofagije. Autofagija se smatra jednim od efektorskih mehanizama urođene imunosti protiv unutarstaničnih bakterija. Podaci o ulozi autofagije u regulaciji citokinske mreže tijekom tularemije su još uvijek rijetki i proturječni. Stoga bi naša daljnja istraživanja, posebno u modelu Atg5 transgeničnih miševa, trebala pridonijeti boljem razumijevanju autofagije kao imunom odgovoru na infekciju francizelom. Očekivani rezultati doprinijet će rasvjetljavanju patogeneze tularemije te pridonijeti razvoju novih terapijskih i preventivnih strategija baziranih na autofagiji.]]></summary_hr><summary_en><![CDATA[Francisella tularensis is a highly virulent facultative intracellular pathogen that causes  disease tularemia. The intracellular lifestyle of F. tularensis is unique compared to other intracellular pathogens. The Francisella-containing phagosome (FCP) is arrested at a non-acidified late endosome-like stage, which is followed by gradual bacterial escape into the cytosol. It is obvious that Francisella cycles through different intracellular compartments; FCP and the Francisella-containing vacuole (FCV). Because of the importance of these subcellular compartments during infection, we will establish a novel method of isolating the FCP/FCV from macrophages. This is an innovative approach in understanding their role in Francisella intracellular life cycle. Secondly, we proposed that the great part of communication with the host cytosol environment is accomplished by autophagy. We assume that Francisella reseal damaged FCV into the autophagic vacuole later during the infection. Many studies have been focused on a genomic region called the Francisella pathogenicity island (FPI). Some of the FPI mutants show a uniform phenotype characterized by lack of phagosomal escape, no intracellular replication, and a loss of virulence in vivo. We expect to find that FPI proteins, PdpC, IglC, IglI, PdpE, and IglG that are effectors of the type VI secretion system are also involved in manipulation of autophagy machinery. Autophagy is regarded as one of the innate immunity effectors against intracellular bacteria. However, the data on the role of autophagy in the regulation of cytokine networks by Francisella are still unknown. We propose a new concept using transgenic Atg5 mouse that should contribute to a better understanding of autophagy as host immune response to Francisella infections. The project will contribute to understanding the pathogenesis of tularemia, providing opportunities for the development of novel autophagy-based therapeutic and preventive strategies.]]></summary_en></project><project>
<id>7548</id><title_hr><![CDATA[Napredni deterministički i hibridni algoritmi na nizovima, sljedovima i stablima s primjenama u tehničkim znanostima i znanostima o životu]]></title_hr><title_en><![CDATA[Advanced deterministic and hybrid algorithms on strings, sequences and trees with applications in technical and life sciences]]></title_en><user_id>4140</user_id><user_firstLast_name>Strahil Ristov</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-7317</code><acronim><![CDATA[ALGSEQ18]]></acronim><duration>01.10.2018 - 30.09.2022</duration><status>Završio</status><financ_value>112.150,77 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, Temeljne tehničke znanosti, Interdisciplinarne tehničke znanosti, </scie_field_hr><scie_field_en>Computer sciences, Basic engineering sciences, Interdisciplinary technological sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>6650, 864917, </team_members_id><team_members_names><![CDATA[Ino Čurik, Dalibor Hršak, ]]></team_members_names><keywords_hr><![CDATA[algoritmi, računarska teorija, kompaktne strukture podataka, promjenljive strukture podataka, bioinformatika, populacijska genetika]]></keywords_hr><keywords_en><![CDATA[algorithms, theoretical computer science, compact data structures, dynamic data structures, bioinformatics, population genetics]]></keywords_en><summary_hr><![CDATA[Deterministički kombinatorni algoritmi na nizovima i sljedovima temeljni su dio u rješenjima mnogih računarskih problema u tehničkim znanostima i znanostima o životu. U tehničkim znanostima radi se o sažimanju, pohrani, te pretrazi i dohvatu podataka. U znanostima o životu ti se postupci specifično primjenjuju na velike količine podataka o biološkim sekvencama. U novije vrijeme, veliko povećanje raspoloživih podataka (big data) stvorilo je potrebu za novim rješenjima i naprednijim algoritmima. U nekim primjenama koriste se hibridni postupci koji uključuju i probabilističke metode, kao što su to skriveni Markovljevi lanci, no u većini rješenja problema na nizovima i sljedovima postoji kombinatorna podloga. U ovom projektu, originalni postupci temeljeni na kombinatornom pristupu, koji je prema potrebi nadopunjen probabilističkim, koristit će se, u području tehničkih znanosti, za konstrukciju kompaktnih struktura podataka i rješavanje dinamičkih problema na nizovima. U  području znanosti o životu istraživat će se mogućnosti rješavanja algoritamskih zadaća u bioinformatici koje proizlaze iz različitih oblika problema  mapiranja kraćih dijelova sekvenci na dulje. Također, u području populacijske genetike istraživat će se mogućnost pronalaženja učinkovitije definicije regija homozigotnosti kod diploidnih organizama, te uključivanja detaljnih podataka o sekvencama u pedigre stabla sa svrhom optimiziranja populacijskih analiza i poboljšanja uzgojnog procesa u komercijalnim vrstama.Uz to, algoritmi na stablima će biti korišteni za optimizaciju postupka izbora jedinki od kojih treba uzeti uzorke DNA za optimalnu analizu populacije.]]></summary_hr><summary_en><![CDATA[Deterministic combinatorial algorithms on strings and sequences are central part of many computational solutions of problems in technical and life sciences. The relevant methods in technical sciences mainly include those for the compression, storage, and search and retrieval of data. In life sciences, these methods are specifically applied on huge amounts of biological sequence data. Recently, large increase in quantity of the available data (big data) has induced the need for novel and advanced algorithmic solutions. Some of the problems require the hybrid solutions that include probabilistic methods, such as hidden Markov models. However, in most of the solutions of the problems on strings and sequences there exists a central combinatorial part. In this project, original methods based on the combinatorial approach, and in some instances complemented with the probabilistic approach, will be used, in the field of computer science, for the construction of compact data structures and for solving dynamical problems on strings. In life sciences field, these types of methods will be used, in bioinformatics, to investigate possible solutions of various algorithmic problems arising from the task of mapping shorter sequence parts to the longer sequence. In the population genetics field, the possibility of finding a more productive definition of regions (runs) of homozigosity in diploid organisms will be investigated, as well as the inclusion of the detailed sequence data into pedigree trees, with the goal of optimizing the population analysis and improving the breeding selection for commercial species. Additionally, algorithms on trees will be used for the optimization of the process of the selection of individuals from which the sample should be taken for the optimal population analysis.]]></summary_en></project><project>
<id>7549</id><title_hr><![CDATA[Profesionalizam u zdravstvu]]></title_hr><title_en><![CDATA[]]></title_en><user_id>776</user_id><user_firstLast_name>Ana Marušić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-3134</code><acronim><![CDATA[ProHealth]]></acronim><duration>01.09.2018 - 31.08.2021</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Javno zdravstvo i zdravstvena zaštita, </scie_field_hr><scie_field_en>Public health and health services, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Split School of Medicine]]></institution_en><team_members_id>25225</team_members_id><team_members_names><![CDATA[ Doktorand: Marin Viđak ]]></team_members_names><keywords_hr><![CDATA[profesionalizam, zdravstvena skrb, profesionalci, integritet, izvrsnost, odgovornost, transparencija]]></keywords_hr><keywords_en><![CDATA[professionalism, health care, students, professionals, integrity, excellence, accountability, transparence]]></keywords_en><summary_hr><![CDATA[Predloženi projekt ima za cilj istraživanje izvrsnosti, odgovornosti i integriteta/transparencije kao atributa profesionalizma koji su relevantni za zdravstvenu skrb utemeljenu na dokazima, gdje je profesionalizam široko definiran kao predanost izvršavanju profesionalne zadaća, pridržavanju etičkih principa i osjetljivosti za pacijentovu dobrobit. Prva istraživačka tema projekta usmjerena je na profesionalizam u studenata. Istražit ćemo determinante profesionalnog razvoja studenata, kao i okružje za razvoj profesionalne izvrsnosti i integriteta. Temeljem nalaza iz tog dijela istraživanja, razvit ćemo i testirati intervencije za poticanje razvoja profesionalizma tijekom studija. Druga istraživačka tema usmjerena je na profesionalizam u praksi zdravstvene skrbi. Prvo ćemo usporediti okvire za profesionalnu izvrsnost i integritet, uključujući i dokaze dostupne zdravstvenim profesionalcima i njihovu translaciju u praksi. Temeljem nalazi iz tog dijela istraživanja, razvit ćemo i testirati intervencije za poboljšanje profesionalne prakse. Pristup svakom specifičnom cilj istraživanja uključit će 1) mapiranje trenutnog znanja i identifikacija područja s manjkavim znanjem, 2) uporabu adekvatnih istraživačkih ustroja i metodologija, 3) sinteza rezultata istraživanja u eksplanatorne teorije i modele i 4) razvoj i diseminacija aplikacija važnih za javnu politiku i pristup zdravstvenoj skrbi. Rezultati predloženih istraživanja pridonijet će boljem razumijevanju kako se profesionalizam razvija tijekom obrazovanja i prakse u zdravstvenoj skrbi. Razvojem i testiranjem novih intervencija za poticanje razvoja profesionalizma, projekt će donijeti dokaze za promicanje kurikularnog i cjeloživotnog učenja i za promjenu politike zdravstvene skrbi, kao i donijeti važne ekonomske i javnozdravstvene koristi.]]></summary_hr><summary_en><![CDATA[The proposed project aims to study excellence, accountability and integrity/transparency as attributes of professionalism which are most relevant for evidence-based healthcare, where professionalism is broadly defined as commitment to carrying out professional responsibilities, adherence to ethical principles and sensitivity to patient populations. The first research theme addresses professionalism in healthcare students. We will investigate the determinants of professional development in students, as well as the environment for the development of professional excellence and integrity. Based on the findings from this research, we will develop and test interventions for teaching professionalism in health curricula. The second research theme addresses professionalism in healthcare practice. We will first describe the framework for professional excellence and integrity, including the evidence available to healthcare practitioners and its translation to practice. Based on research results, we will develop and test interventions for professional practice. Each specific objective will include: 1) mapping of current research results and identification of knowledge gaps, 2) using appropriate research design and methodology, 3) synthesising research results into explanatory theories and models, and 4) developing and disseminating applications relevant for policy and public use. Results from the proposed research will contribute to better understanding of how professionalism develops during healthcare education and practice. By developing and testing new interventions for professionalism, the project will provide evidence for the advancement of curricular and life-long learning and policy changes in healthcare, as well as bring important economic and public health benefits.]]></summary_en></project><project>
<id>7550</id><title_hr><![CDATA[Detaljan uvid u mehanizme polaronske i ionske vodljivosti u oksidnoj staklo-(keramici)]]></title_hr><title_en><![CDATA[Expanding insights into the mechanisms of POLARonic and IONic conduction in oxide GLASS-(ceramics)]]></title_en><user_id>3297</user_id><user_firstLast_name>Ana Šantić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-5425</code><acronim><![CDATA[POLAR-ION-GLASS]]></acronim><duration>19.10.2018 - 18.03.2023</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>4869, 3421, 3302, 23899, 13670, 13669, 23663, 13648, 26576, 865074, </team_members_id><team_members_names><![CDATA[Andrea Moguš-Milanković, Luka Pavić, Kristina  Sklepić, Radha Dilip Banhatti, Ladislav Koudelka, Petr Mosner, Petr Kalenda, Grégory Tricot, Sanja Renka, Sara Marijan, ]]></team_members_names><keywords_hr><![CDATA[staklo, staklo-keramika, ionska vodljivost, polaronska vodljivost, struktura]]></keywords_hr><keywords_en><![CDATA[glasses, glass-ceramics, ionic conductivity, polaronic conductivity, structure]]></keywords_en><summary_hr><![CDATA[Električki vodljiva oksidna stakla važni su elektrolitni/elektrodni materijali koji se sve više primijenjuju u modernim elektrokemijskim uređajima. U ovim staklima tip električne vodljivosti (polaronski, ionski ili miješani ionsko-polaronski) ovisi o sastavu stakla, dok utjecaj međudjelovanja nositelja naboja s lokalnim strukturnim okruženjem definira mehanizam transporta. Zbog strukturne neuređenosti i velike raznolikosti strukturnih jedinica razumijevanje električnog transporta na mikroskopskoj skali u staklu predstavlja veliki izazov. Glavni je cilj predloženog projekta razjasniti mehanizme polaronske i ionske vodljivosti u volframsko- i molibdensko-fosfatnim staklima i staklo-keramici s posebnim naglaskom na povezanost sa strukturom. Predloženo istraživanje sastoji se od tri međusobno povezana koraka: 1) određivanje faktora koji određuju polaronsku vodljivost u binarnim volframsko- i molibdensko-fosfatnim staklima, 2) istraživanje miješanog ionsko-polaronskog transporta u volframsko- i molibdensko-fosfatnim staklima koja sadrže alkalijske okside i 3) ispitivanje utjecaja kristalizacije na električni transport u odabranim modelnim staklima iz koraka 1) i 2) s ciljem priprave vodljive staklo-keramike s prilagodljivim doprinosom ionske i polaronske vodljivosti. Odabrani sustavi posebno su atraktivni za primjenu kao katode u krutim baterijama jer fosforov oksid tvori stakla s alkalijskim i prijelaznim metalnim oksidima u širokom koncentracijskom području što omogućava visoku polaronsku i ionsku vodljivost. Detaljna strukturna i električna karakterizacija neophodna za rasvjetljavanje i povezivanje procesa polaronskog i ionskog transporta u ovim materijalima provest će se nizom naprednih komplementarnih metoda (Ramanska, MAS NMR i EPR spektroskopija, neutronska i rendgenska difrakcija, impedancijska spektroskopija, DC mjerenja), a značajan uvid u elementarne procese gibanja polarona i iona dat će numeričko modeliranje električne provodnosti MIGRATION konceptom.]]></summary_hr><summary_en><![CDATA[Electrically conducting oxide glasses are an important class of electrolyte/electrode materials whose application in modern electrochemical devices are growing rapidly. The type of conduction (polaronic, ionic or mixed polaronic-ionic) in these glasses depends on the composition, while the transport mechanism itself is strongly influenced by the interaction of charge carriers with the local structural environment and understanding it from a microscopic point of view poses a major challenge. The overall aim of the proposed project is to clarify the mechanisms of polaronic and ionic conduction in tungsten phosphate and molybdenum phosphate glasses and glass-ceramics with a special emphasis on their correlation to the structure. The proposed research contains three interconnected steps: 1) identification of factors that govern polaronic conduction in binary tungsten/molybdenum phosphate glasses, 2) investigation of the mixed conduction in tungsten/molybdenum phosphate glasses containing alkali oxides and 3) study of the influence of crystallization on electrical transport in selected glasses from steps 1) and 2) in order to obtain highly conductive glass-ceramics with tuneable contributions of polaronic and ionic conduction. The chosen phosphate glasses are especially attractive for application as cathodes in solid-state batteries because they can accommodate a considerable amounts of transition metal and alkali oxides, and hence exhibit high polaronic and ionic conductivity. Detailed structural and electrical characterizations which are needed for resolving and relating processes of polaronic and ionic transport in these materials will be achieved using various advanced methods (Raman, MAS NMR and EPR spectroscopy, neutron and X-ray diffraction, impedance spectroscopy, DC measurements), while the numerical modelling of electrical conductivity using MIGRATION concept will give additional valuable insights into the elementary processes of polaronic and ionic motions.]]></summary_en></project><project>
<id>7551</id><title_hr><![CDATA[Sinkroni reluktantni generatori za mikro hidroelektrane]]></title_hr><title_en><![CDATA[Synchronous reluctance generators for micro hydropower plants]]></title_en><user_id>1528</user_id><user_firstLast_name>Stjepan Stipetić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-5822</code><acronim><![CDATA[HYDREL]]></acronim><duration>01.11.2018 - 31.10.2022</duration><status>Završio</status><financ_value>128.910,88 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Temeljne tehničke znanosti, Elektrotehnika, </scie_field_hr><scie_field_en>Basic engineering sciences, Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>23934, 19026, 6380, 3873, 2534, 3953, 22617, 2703, 22554, 6695, 23940, 28672, 25402, 25401, 25403, 5949, </team_members_id><team_members_names><![CDATA[Ivana Pavlić, Igor Sirotić, Igor Erceg, Damir Žarko, Marinko Kovačić, Zlatko Hanić, Filip Jukić, Mario Vražić, Luka Pravica, Martina Kutija, Nikola Vuger, Marijan Martinović, Niksa Ćavar, Mario Klanac, Dora Penić, Damir Sumina, ]]></team_members_names><keywords_hr><![CDATA[sinkroni generatori, reluktantni strojevi, mikro hidroelektrane, optimizacija, energetski pretvarači]]></keywords_hr><keywords_en><![CDATA[synchronous generators, reluctance machines, micro hydropower plants, optimisation, power electronic converter]]></keywords_en><summary_hr><![CDATA[Učinkovita potrošnja energije i povećana upotreba energije iz obnovljivih izvora su promovirane strateškim planovima Europske unije i Hrvatske. Mikro, mini i male hidroelektrane imaju značajan neiskorišteni potencijal i prednost pred energijom vjetra i sunčevom energijom u stabilnijoj i predvidivoj proizvodnji. Vodna turbina i električni generator su ključni elementi takvih sustava koji trebaju imati nisku cijenu, visoku učinkovitost i pouzdanost. Novi sustavi za pretvorbu energije su temeljeni na turbini promjenjive brzine vrtnje i na generatoru spojenom na energetski pretvarač čime se ostvaruje fleksibilan sustav za upravljanje radnom i jalovom snagom. Topologije generatora, koje nude visoku učinkovitost, temeljene su na stalnim magnetima s elementima rijetkih zemalja koji imaju visoku i nestabilnu cijenu na tržištu i čija proizvodnja ima iznimno negativan učinak na okoliš. Alternativa strojevima sa stalnim magnetima su sinkroni reluktantni strojevi, jednostavnog robusnog dizajna bez magneta, visoke učinkovitosti i niske cijene.Projekt HYDREL istražuje mogućnosti korištenja reluktantnih strojeva kao generatora u mikro hidroelektranama. Istraživanja i inovacije na projektu HYDREL su usredotočeni na sljedeće ciljeve: (i) istraživanje koncepta proizvodnje energije u mikro hidroelektranama inovativnim simulacijskim sustavom, (ii) istraživanje inovativnih i optimalnih oblika rotorskih barijera uz projektiranje i izradu prototipa reluktantnih generatora visoke učinkovitosti, (iii) projektiranje i izradu prototipa energetskog pretvarača s optimiranim filterskim komponentama, (iv) istraživanje inovativnog upravljačkog algoritma za energetski učinkovito upravljanje uz identifikaciju i adaptaciju parametara generatora. Razvijeni koncepti će biti potvrđeni simulacijskim modelima i eksperimentalno na laboratorijskom postavu dva mehanički spojena prototipna stroja, koji predstavljaju turbinu i generator, a spojeni su na mrežu preko prototipa energetskog pretvarača.]]></summary_hr><summary_en><![CDATA[Efficient energy consumption and the increased use of energy from renewable sources are promoted by strategic plans of the European Union and Croatia. Micro, mini and small hydropower plants have a significant unused potential and an advantage over wind and solar in more stable and predictable energy production. Water turbine and electrical generator are the key elements of such systems which need to have low cost, high efficiency, and reliability. Novel systems for energy conversion are based on the variable speed turbine and on the synchronous generator coupled with the power converter thus forming a flexible system capable of active and reactive power control. The most efficient generator topologies are based on rare-earth permanent magnets which have high and unstable price and whose manufacturing has an extremely negative environmental impact. An alternative to permanent magnet machines are the synchronous reluctance machines, which have simple robust design without magnets, high efficiency, and low cost.HYDREL project explores the capability of exploiting synchronous reluctance machine as a main generating unit in a micro hydropower plant. As a step forward in research and innovation, the focus of HYDREL is set on the following objectives: (i) research on power generation concept of micro hydropower plant through innovative simulation environment, (ii) research on innovative and optimal rotor flux barrier shapes along with design and prototyping of two high-efficiency synchronous reluctance generators, (iii) design and prototyping of power electronic converter with optimized filter components, (iv) research on innovative energy-efficient control algorithm with identification and adaptation of generator parameters. The developed system will be experimentally verified on the test rig consisting of two coupled prototyped machines representing turbine-generator system connected to the electrical grid through a prototyped power electronic converter.]]></summary_en></project><project>
<id>7552</id><title_hr><![CDATA[Unapređenje usluga šumskih ekosustava Hrvatske kroz vrednovanje bioraznolikosti gljiva temeljenoj na DNA barkodiranju]]></title_hr><title_en><![CDATA[Enhancement of Croatian forest ecosystem services through assessment of fungal diversity based on DNA barcoding ]]></title_en><user_id>19224</user_id><user_firstLast_name>Armin Mešić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-1736</code><acronim><![CDATA[ForFungiDNA]]></acronim><duration>01.10.2018 - 15.02.2023</duration><status>Završio</status><financ_value>126.153,03 eur</financ_value><scie_area_hr>Biotehničke znanosti, Prirodne znanosti, </scie_area_hr><scie_area_en>Biotechnical sciences, Natural sciences, </scie_area_en><scie_field_hr>Šumarstvo, Biologija, Interdisciplinarne biotehničke znanosti, </scie_field_hr><scie_field_en>Forestry, Biology, Interdisciplinary biotechnical sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>5710, 13114, 12839, 13120, 13180, 12438, 5744, 23931, 23880, 23894, 5235, 27440, 26553, 865066, </team_members_id><team_members_names><![CDATA[Zdenko Tkalčec, Ivana Kušan, Margita Jadan, Neven Matočec, Tine Grebenc, Željko Zgrablić, Sanja Novak Agbaba, Dino Buršić, Ondřej Koukol, Luis Jesús Quijada Fumero, Nevenka Ćelepirović, Zuzana  Sochorová , Ana Pošta, Lucia Pole, ]]></team_members_names><keywords_hr><![CDATA[šumarstvo, usluge šumskih ekosustava, gljive, bioraznolikost, DNA barkodiranje, integrativna taksonomija, biogeografija, fitopatologija]]></keywords_hr><keywords_en><![CDATA[forestry, forest ecosystem services, fungi, biodiversity, DNA barcoding, integrative taxonomy, biogeography, phytopathology]]></keywords_en><summary_hr><![CDATA[Usluge ekosustava su ekološke značajke, funkcije ili procesi ekosustava koji imaju utjecaj na ljudsko blagostanje. Očuvanje cjelokupne biološke raznolikosti u šumama ima izrazito pozitivan utjecaj na unapređivanje usluga šumskih ekosustava. U ukupnoj kopnenoj površini Republike Hrvatske šume zauzimaju oko 37%. Zbog položaja na razmeđi kontinentalne, sredozemne, panonske i alpske biogeografske regije, Hrvatska se u europskim okvirima ističe vrlo velikom bioraznolikošću. Šume su najsloženiji kopneni ekosustavi i najznačajniji tip staništa za gljive u kojem živi najveći broj gljivljih vrsta. Gljive u šumskim staništima imaju ključne ekološke uloge i nužne su za zdravlje i opstanak šuma. Ljudski utjecaj koji se ogleda u često prekomjernom iskorištavanju prirodnih resursa i položaj u jednom od svjetskih žarišta klimatskih promjena čine biološku raznolikost u hrvatskim šumama vrlo ugroženom. Gljive su u Hrvatskoj daleko najslabije istražena skupina organizama, pri čemu je do danas poznato tek oko 23% od ukupno procijenjenog broja vrsta. Glavni cilj projekta je istražiti bioraznolikost gljiva u šumama Hrvatske uz pomoć metoda DNA barkodiranja, te analizirati njen utjecaj na usluge šumskih ekosustava. Važan rezultat projekta biti će nadopunjavanje bioinformatičkih međunarodnih baza podataka DNA sekvencama gljivljih vrsta koje do danas u tim bazama nisu zastupljene. Sve vrste za koje su u ovom projektu dobiveni DNA barkodovi kategorizirat će se u trofičke skupine (patogene, mikorizne i saprotrofne vrste) i procijenit će se status ugroženosti tih vrsta u Hrvatskoj. Rezultati projekta imat će veliki potencijal primjene u šumarstvu, prehrambenoj industriji, farmaciji te zaštiti prirode. Podaci o DNA barkodovima vrsta gljiva posebno će biti značajni u šumarstvu za relativno brzu i preciznu identifikaciju, kontrolu i suzbijanje patogena drveća, ali i za identifikaciju mikoriznih i saprotrofnih vrsta.]]></summary_hr><summary_en><![CDATA[Ecosystem services are the ecological characteristics, functions, or ecosystem processes that contribute to human wellbeing. Conservation of the overall biodiversity in the forests has strong positive effect on the enhancement of forest ecosystem services. About 37% of the total land area of the Republic of Croatia is covered by forests. Croatia is distinguished by the great biodiversity due to its position on the dividing line between Continental, Mediterranean, Pannonian and Alpine biogeographical regions. Forests are the most complex terrestrial ecosystems and the most important habitat for fungi. Fungi play key ecological roles in the forests and are necessary for the forest health and existence. Human over-exploitation of natural resources and the geographical position of Croatia in the climate change hot-spot area, make biodiversity of its forests highly endangered. Fungi are the far least studied group of organisms in Croatia with only 23% of species recorded so far out of the total estimated number. The main project aim is to study fungal biodiversity of Croatian forests through the DNA barcoding methods and to analyze its impact on forest ecosystem services. The project will result in the addition of fungal DNA sequences to international bioinformatic databases for a number of species that are not represented in these bases to date. All DNA barcoded species in this project will be categorised in trophic groups (pathogens, saprotrophs, and mycorrhizal species) and the intensity of their impact on the forest ecosystem services will be assessed. The project results will have great potential for different applications in forestry, food industry, pharmacy and nature conservation. Application of DNA fungal barcodes will be especially important in forestry for relatively fast and accurate identification, control, and suppression of plant pathogens, as well as for identification of mycorrhizal and saprotrophic species.]]></summary_en></project><project>
<id>7558</id><title_hr><![CDATA[Dinamika defekta u nanomaterijalima: istraživanje putem eksperimenata s ionskim tragovima]]></title_hr><title_en><![CDATA[Defects dynamics in NanoMaterials: research based on Ion Track Experiments]]></title_en><user_id>3498</user_id><user_firstLast_name>Marko Karlušić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-2786</code><acronim><![CDATA[DyNaMITE++]]></acronim><duration>01.11.2018 - 31.12.2022</duration><status>Završio</status><financ_value>132.457,36 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>21267, 4589, 4976, 2639, 5438, 25833, 25293, 865268, </team_members_id><team_members_names><![CDATA[Kristina Tomić, Stjepko Fazinić, Iva Božičević Mihalić, Pavo Dubček, Branko Šantić, Juraj Hanžek, Damjan Iveković, Sunil Kumar, ]]></team_members_names><keywords_hr><![CDATA[brzi teški ion, ionski trag, defekt, RBS/c, Ramanova spektroskopija, AFM, grafen]]></keywords_hr><keywords_en><![CDATA[swift heavy ion, ion track, defect, RBS/c, Raman spectroscopy, AFM, graphene]]></keywords_en><summary_hr><![CDATA[Napredni materijali i napredne tehnike procesiranja materijala osnova su suvremene tehnologije. Znanstveni napredak započet nedavnim otkrićem grafena koji u jednom materijalu sažima više izvanrednih svojstava, obećaje naslućene mogućnosti koje bi mogle uzrokovati velike promjene u sadašnjim industrijskim procesima i rezultirati radikalno novim proizvodima. Zato je kontrola svojstava ovih novih i uzbudljivih nanomaterijala od najveće važnosti za bilo koju industrijsku primjenu.Ionska implantacija je dobar primjer u kojem električna svojstva poluvodiča mogu biti dopiranjem podešavana u ogromnom rasponu. Visokoenergetska ozračavanja ionima se također mogu koristiti za kontroliranje svojstava materijala, ali putem inženjeringa defekata (tj. pomoću ionskih tragova). Ova vrsta zračenja je našla mnogobrojne primjene, npr. u proizvodnji membrana, hadronterapiji i istraživanjima skladištenja nuklearnog otpada.Cilj projekta je detaljno istraživanje defekata i njihove dinamike u naprednim materijalima tijekom zračenja visokoenergetskim ionima, a u svrhu da bi se odredili pogodni uvjeti za inženjering defekata. U fokusu su istraživanja defekata u grafenu i drugim izabranim 2D materijalima pomoću AFM/STM i Ramanove spektroskopije. Komplementarno ovom istraživanju bit će provedene studije o inženjeringu defekata putem visokoenergetskih ionskih snopova u drugim tehnološki važnim materijalima pomoću RBS/c-PIXE/c i AFM. Kako bi zadobili potpunu kontrolu nad defektima unesenim putem ionskih snopova, važno je razumijeti osnovne procese koji utječu na stvaranje defekata i njihovu dinamiku. Stoga, očekujemo da rezultati projekta pruže uvid u procese koji vladaju dinamikom defekata u naprednim materijalima tijekom zračenja ionima. Očekujemo da će rezultati projekta imati utjecaj na primjene poput senzora i katalizatora, putem novih funkcionalnih svojstava materijala dobivenih inženjeringom defekata. ]]></summary_hr><summary_en><![CDATA[Advanced materials and advanced materials processing techniques are basis of the present-day technology. Scientific advances initiated by recent discovery of graphene that captures many extraordinary properties in a single material promises unpreceded benefits that should justify disruption of current industrial processes, thus giving birth to radically new products. Clearly, to control properties of these new and exciting nanomaterials is of paramount importance for any kind of industrial application. Ion implantation is good example where electrical properties of semiconductors can be tuned in extraordinary wide range by ion doping. High energy ion irradiations can also be used to control materials properties, but in this instance control is achieved via defect engineering (i.e. ion tracks). This kind of irradiation has found many uses in diverse applications like track-etch-membrane production, hadron therapy, and nuclear waste storage studies.The aim of the project is to study in detail defects and their dynamics in advanced materials during high energy ion irradiation, in order to establish suitable conditions for defects engineering. In the research focus is defects analysis in graphene and other selected 2D materials using AFM/STM and Raman spectroscopy. Complementary to this research, studies of defects engineering by high energy ion beams in other technologically relevant materials using RBS/c-PIXE/c and AFM will be undertaken. To gain full control over defect engineering using ion beams, it is important to understand basic mechanisms governing defect production and their dynamics. Therefore, expected results of the project will provide insight into processes governing defect dynamics in advanced materials during ion irradiation. We expected project results to have impact on applications, like sensing and catalysis, due to new materials functionalities gained by defects engineering.]]></summary_en></project><project>
<id>7559</id><title_hr><![CDATA[Laboratorij za geoprostorne analize]]></title_hr><title_en><![CDATA[]]></title_en><user_id>12395</user_id><user_firstLast_name>Ante Šiljeg</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-5748</code><acronim><![CDATA[GAL / GAL]]></acronim><duration>18.12.2019 - 17.07.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Interdisciplinarno područje znanosti</scie_area_hr><scie_area_en>Interdisciplinary scientific area</scie_area_en><scie_field_hr>Geografija, </scie_field_hr><scie_field_en>Geography, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zadru]]></institution_hr><institution_en><![CDATA[University of Zadar]]></institution_en><team_members_id>22524</team_members_id><team_members_names><![CDATA[ Doktorand: Neda Kulenović ]]></team_members_names><keywords_hr><![CDATA[daljinska istraživanja, GIS, LiDAR, morfometrijske analize, UAV, višekriterijske analize]]></keywords_hr><keywords_en><![CDATA[GIS, LiDAR, morphometric analysis, multi-criteria decision analysis, remote sensing, UAV]]></keywords_en><summary_hr><![CDATA[Osnovni  cilj projekta  je uspostava  Laboratorija  za geoprostorne analize  (GAL)  pri  Odjelu  za  geografiju  Sveučilišta  u  Zadru  te  okupljanje  interdisciplinarnog  tima  znanstvenika  iz  različitih  znanstvenih  polja (geografija,  arheologija, geodezija, agronomija). Osnovna  svrha GAL-a  je  provođenje  znanstvenih  istraživanja,  edukacija  mladih  istraživača, primjena novih znanja i tehnologija te razvoj  inovativnih metoda istraživanja. Prva faza uspostave usmjerena je na opremanje laboratorija s najsuvremenijim  uređajima  uz istovremeno usavršavanje istraživačkog  tima. Primjenom GIS-a u kombinaciji sa korištenjem tehnologije daljinskih istraživanja (bespilotna letjelica, 3D-skener, LiDAR, infracrvena kamera, termalna kamera itd.) omogućava se proučavanje određenog procesa  ili pojave u krupnom mjerilu, pri čemu su sve karakteristike promatranog objekta mjerljivo, odnosno kvantitativno opisane. Stoga je drugi cilj ovog projekta usmjeren na primjenu geoprostornih analiza u primijenjenim istraživanjima kroz  (a)  razvoj   višekriterijskog   modela  održivog  upravljanja   na  području  sedrotvornih vodotoka (b) razvijanje novog metodološkog pristupa u proučavanju  jaruga i (c)  pronalaženje  praktičnih  rješenja  kroz  primjenu  geoprostornih  analiza  u arheologiji i agronomiji. Ostvarenje navedenih ciljeva i izvedeni rezultati pokazali bi primjenjivost i opravdanost laboratorija u daljnjim znanstvenim istraživanjima. Jedinstveni doprinos ostvarenja ovog projekta očituje se u tome da bi GAL predstavljao prvi laboratorij za geoprostorne analize u RH koji će biti usmjeren na usavršavanje te promociju i edukaciju mladih znanstvenika kroz njihovo uključivanje u rad laboratorija. Znanstveni doprinos ovog istraživanja iskazati će se kroz pisanje dvije doktorske disertacije, čiji je osnovni cilj istraživanja izrada prvog plana održivog upravljanja sedrotvornim vodotocima te razvoj novog metodološkog koncepta za proučavanje jaruga. ]]></summary_hr><summary_en><![CDATA[The main aim of the project is to set up a Geospatial Analysis Laboratory (GAL) at the Department of Geography, University of Zadar, and to gather an interdisciplinary team of scientists from various fields (geography, archaeology, geodesy, agronomy). GAL&#39;s basic aim is to produce scientific research, educate young researchers, apply new knowledge and technology, and develop innovative research methods. The first phase of the application focuses on equipping the laboratory with the most up-to-date devices and accompanying software, while training the research team. The use of GIS in combination with RS technology (unmanned aerial vehicle, 3D scanner, LiDAR, infrared camera, thermal camera, etc.) facilitates the study of certain processes or phenomena at close range, while their characteristics are measurable, i.e. can be described quantitatively. Therefore, the second goal of the project focuses on the application of geospatial analyses in applied research through (a) the development of multicriteria models of sustainable management in the area of tufa-forming watercourses, (b) the development of a new methodical approach to studying gullies, and (c) discovering practical solutions through applying geospatial analyses in archaeology and agronomy. Achieving these goals and the results produced would demonstrate to applicability of and justification for GAL in further scientific research. The unique contribution of this project would be the creation of the first laboratory for geospatial analysis in Croatia, focusing on training, promoting and educating young scientists by engaging them in its work. The scientific contribution of this research will be seen in two doctoral dissertations, whose basic research topics are concerned with the production of the first plan for the sustainable management of tufa-forming watercourses, and the development of a new methodological concept for studying gullies. ]]></summary_en></project><project>
<id>7560</id><title_hr><![CDATA[Transformacija pepela iz drvene biomase u građevne kompozite s dodanom vrijednošću]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3406</user_id><user_firstLast_name>Nina Štirmer</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-3084</code><acronim><![CDATA[TAREC2]]></acronim><duration>22.10.2018 - 15.01.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Građevinarstvo, </scie_field_hr><scie_field_en>Civil engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Građevinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Civil Engineering]]></institution_en><team_members_id>25367</team_members_id><team_members_names><![CDATA[ Doktorand: Jelena Šantek Bajto ]]></team_members_names><keywords_hr><![CDATA[drvna biomasa, pepeo drvne biomase, mineralni kompozit, građevni proizvod, trajnost]]></keywords_hr><keywords_en><![CDATA[wood biomass, wood biomass ash, mineral composite, construction product, durability ]]></keywords_en><summary_hr><![CDATA[Energane na krutu i plinovitu biomasu predstavljaju jedan od najznačajnijih obnovljivih izvora energije u Europskoj uniji te se očekuje da će biti jedan od glavnih aktera pri dostizanju europskog plana za primjenu 20 % obnovljive energije u 2020. Uobičajeno se tijekom izgaranja 1 tone drvne biomase proizvede 5 MWh energije, ali i 20 – 50 kg pepela s dna peći kao i letećeg pepela. Predviđa se da će u EU-28 primjena energije iz energana na drvnu biomasu u budućnosti utjecati na proizvodnju približno 600 000 tona pepela. Trenutno se 70 % biopepela drvne biomase (PDB) odlaže, 20 % se nastoji primijeniti kao dodatak tlu u poljoprivredi i 10 % za ostale namjene. Strategijom energetskog razvoja RH određeno je da će se do 2020. godine koristiti 85 MWe iz biomase. U ožujku 2016. u Hrvatskoj je bilo 10 elektrana na biomasu, potpisano je 57 ugovora s Hrvatskim operatorom tržišta energije za gradnju elektrana u 2014. i 2015. godini (ukupno 95,342 MWe) te su zaprimljeni zahtjevi za odobrenje građenja dodatnih elektrana na biomasu snage 51,034 MWe.Cilj projekta TAREC2 je transformirati pepeo drvne biomase (PDB) u građevne kompozite s dodanom vrijednošću, kroz povezivanje tri ključna aktera s njihovim specifičnim interesima, u industrijsku simbiozu sa zajedničkim komplementarnim interesom, koji je u skladu s EU pravnim okvirima. Prvi akter je energetski sektor koji je korisnik drvne biomase kako bi proizveo energiju i kao rezultat toga proizvođač otpada drvne biomase. Drugi je građevinski sektor koji je korisnik sirovine koju proizvodi energetski sektor. Na kraju, znanost o materijalima služi kao poveznica između dva sektora koja osigurava podatke o sirovini i moguće primjene. Projekt uključuje i optimizaciju i modifikaciju cijelog lanca u tehnologiji procesa: dobivanje pepela iz energetskog procesa, karakterizaciju pepela, određivanje udjela sastojaka mješavine za građevinsku industriju i konačno demonstraciju razvijenog proizvoda i primjenu u građevinskoj industriji. ]]></summary_hr><summary_en><![CDATA[Solid and gaseous biomass fuelled power plants are the biggest source of renewable energy in the EU and are expected to make a key contribution to the 20% EU renewable energy target by 2020. Typically burning of 1 tons of forest biomass and wood waste generates 5 MWh of energy as well as 20 – 50 kg/t of bottom ash and fly ash. It is foreseen that the use of energy from wood biomass plants will lead in the future to the production of approximately 600 000 tons of biomass ash in the EU-28. Currently, 70% of wood biomass ash (WBA) is land filled, 20% tends to be used as a soil supplement in agriculture and 10% is used for miscellaneous application. Energy Sector Development Strategy of the Republic of Croatia determined that by 2020 use of energy from biomass should be 85 MW. In March 2016, there were 10 biomass power plants installed (total power 24.585 MWe). Additionally, 57 contracts were signed with Croatian energy market operator for construction of power plants during 2014 and 2015 (in total 95.342 MWe), while HROTE received requests for approval of construction of additional 51.034 MWe of biomass power plants.TAREC2 aims to transform waste wood biomass ash (WBA) into resilient construction composites, through incorporating three key actors, into an industrial symbiosis with joint complementary interest that is in accordance with EU legal framework. First key actor is the energy sector; user of wood biomass to produce energy and consequently producer of waste wood biomass ash. Another one is construction industry; user of raw material provided by the energy sector. Finally, materials science acts as a bridge between the two sectors, providing information on properties of obtained material and potential application. Project involves the optimization and the modification of the whole chain of process technology: ash obtaining and characterization, mixture proportioning and demonstration of the developed products and the applications in construction industry.]]></summary_en></project><project>
<id>7561</id><title_hr><![CDATA[Dinamični hibridni materijali za novu primjenu temeljeni na metalnim nanočesticama i gelovima]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4406</user_id><user_firstLast_name>Zoran Džolić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-4114</code><acronim><![CDATA[NanoGelMat]]></acronim><duration>17.09.2018 - 18.09.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>25267</team_members_id><team_members_names><![CDATA[ Doktorand: Toni Grgurić ]]></team_members_names><keywords_hr><![CDATA[supramolekulska kemija, gelovi, metalne nanočestice, plazmoni, meki materijali]]></keywords_hr><keywords_en><![CDATA[supramolecular chemistry, gels, metal nanoparticles, plasmons, soft materials]]></keywords_en><summary_hr><![CDATA[Proučavanje fenomena kiralnosti kod anorganskih nanočestica postaje jedna od vodećih tema istraživanja u nanoznanosti. Otkrivena su nova i zanimljiva svojstva kiralnih nanočestica koja pokazuju buduću primjenu tih sustava u temeljnim (metamaterijali) i primijenjenim (medicinska dijagnostika, terapija karcinoma) istraživanjima. Kiralnost nanočestica je važan parametar u utrci minijaturizacije. Cilj je pripraviti kiralne nanočestice s efektom cirkularnog dikroizma induciranog površinskim plazmonom (SP-CD) u vidljivom i infracrvenom dijelu spektra. Napredak u ovom području istraživanja do sada je bio otežan zbog strukturne složenosti takvih sustava te kompliciranih metoda priprave kiralnih nanočestica. Zbog toga je razvoj učinkovitih metoda priprave kiralnih nanočestica jedan od vodećih izazova s kojim se nanoznanost danas suočava. Nedavno smo izložili novi pristup dizajnu i pripravi kiralnih nanočestica. U njemu je kiralna organizacija nanočestica dobivena upotrebom predloška, supramolekularne gelne niti, po kojem je raspored nanočestica dirigiran &#39;&#39;upisanom informacijom&#39;&#39; unutar gelnih niti. Našim pristupom plazmonski cirkularni dikroizam je dobiven samo-udruživanjem zlatnih nanoštapića po predlošku, gelne niti, s upletenom (engl. twisted) morfologijom. Spektri cirkularnog dikroizma su pokazali intenzivne plazmonom-inducirane Cottonove efekte, a dobivene su do sada najviše vrijednosti anizotropnog faktora za metalne nanočestice u otopini. Predloženi projekt ima za za cilj pojasniti porijeklo fenomena kiralnosti kod anorganskih nanočestica i na molekularnoj razini proširiti saznanja o interakcijama između anorganskih nanočestica i molekula gelatora unutar gelne mreže. Nadalje, unutar ovog projekta planirano je istražiti, upotrebom oksalamidnih derivata kao molekula gelatora, mehanizam nastajanja gelnih niti s kiralnom morfologijom, kao i mogućnosti kontrole dobivene morfologije. ]]></summary_hr><summary_en><![CDATA[The observation of chirality on inorganic nanoparticles (NPs) systems is an interesting and highly important phenomenon which has recently attracted considerable attention and has become a hot topic in nanoscience research. Many novel and interesting properties of chiral NPs have been explored and studied, showing that these systems could be of significant importance in both fundamental and application-oriented research. Very recently we have introduced a new strategy for designing and preparing chiral NPs which relies on a gelator fiber-templated approach in which the local organization is driven by the information already inscribed on the gel fibers. Plasmonic circular dichroism was obtained by chiral 3D organisation of gold nanorods, generated by their self-assembly onto a gel fiber template with twisted morphology. Circular dichroism measurements revealed intense plasmon-induced Cotton effect, and the highest anisotropy factor for metal nanoparticles in solution reported so far. The aim of this project is to gain a molecular-level understanding of the interaction of NPs with the gelators within the gel matrix and of the origin of the chirality observed in the inorganic NPs. Furthermore, a comprehensive understanding of the mechanism of the twist formation and control the chiral twists in oxalamide-based gelator assemblies will be sought. The long-term objective of this project is to explore the correlation between the morphology of the chiral gel fibers and the SP-CD responses of NPs. More specifically, the project will focus on (1) the preparation of nanocomposite chiral materials built-up from supramolecular fibers of different morphology serving as templates for surface assembly of NPs; (2) the screening of their optical properties and on identifying the factors responsible for an efficient optical enhancement; (3) the determination of the characteristics and the origins of the chirality in NPs.]]></summary_en></project><project>
<id>7563</id><title_hr><![CDATA[Stohastički procesi sa skokovima i nelokalni operatori]]></title_hr><title_en><![CDATA[Discontinuous stochastic processes and non-local operators]]></title_en><user_id>145</user_id><user_firstLast_name>Zoran Vondraček</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-4197</code><acronim><![CDATA[DISPNOLO]]></acronim><duration>01.10.2018 - 30.09.2022</duration><status>Završio</status><financ_value>91.578,74 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>987, 635, 19068, 23258, 858435, </team_members_id><team_members_names><![CDATA[Nikola Sandrić, Vanja Wagner, Stjepan Šebek, Ivan Biočić, Indranil Chowdhury, ]]></team_members_names><keywords_hr><![CDATA[stohastički procesi sa skokovima, teorija potencijala, stohastička analiza, nelokalni operatori, semilinearne jednadžbe]]></keywords_hr><keywords_en><![CDATA[discontinuous stochastic processes, potential theory, stochastic analysis, non-local operators, semilinear equations]]></keywords_en><summary_hr><![CDATA[Mnoge slučajne pojave u životu i znanosti ne odvijaju se neprekidno u vremenu već imaju isprekidano ponašanje koje se očituje kroz iznenadne promjene stanja. Stohastički procesi sa skokovima modeliraju dinamiku takvih slučajnih evolucija. Slučaj kada evolucija zaboravlja svoju prošlost vodi do Markovljevog svojstva stohastičkog procesa. Markovljevi procesi su kroz svoje infinitezimalne generatore povezani s funkcionalnom analizom i teorijom parcijalnih diferencijalnih jednadžbi. Infinitezimalni generator Markovljevog procesa sa skokovima je nelokalni, integro-diferencijalni operator. Cilj ovog projekta je proučavanje određene klase stohastičkih procesa sa skokovima i nelokalnih operatora, pripadajuće teorije potencijala, teorije stabilnosti i veze s teorijom parcijalnih diferencijalnih jednadžbi. Preciznije, naši ciljevi su istraživanje sljedećih problema: (1)  Studirati Markovljev proces sa skokovima na omeđenom podskupu Euklidskog prostora definiran pomoću svoje jezgre skokova koja osim udaljenosti između točaka uzima u obzir i udaljenost točaka do granice podskupa. Postavljamo pitanje konstrukcije takvog procesa, te proučavamo njegovu teoriju potencijala, svojstva stabilnosti i analitička svojstva; (2) Proširiti neke dijelove teorije semilinearnih jednadžbi za eliptičke diferencijalne operatore na nelokalne operatore kao što su frakcionalni Laplaceov operator te općenitiji nelokalni operatori koji zadovoljavaju izvjesna slaba svojstva skaliranja. Konačni cilj je pronaći vjerojatnosnu interpretaciju rješenja semilinearnih jednadžbi za nelokalne operatore; (3) Primijeniti stohastičke procese sa skokovima u teoriji rizika.Metode istraživanja koje koristimo dolaze iz teorije vjerojatnosti, teorije potencijala, parcijalnih diferencijalnih jednadžbi i funkcionalne analize. Očekivani rezultat predloženog istraživanja je daljnji razvoj nekih aspekata teorije stohastičkih procesa sa skokovima i nelokalnih operatora i doprinos dubljem razumijevanju teorije. ]]></summary_hr><summary_en><![CDATA[Many random phenomena in real life and science do not evolve continuously in time, but rather have abrupt behaviour, manifested through a sudden change of states. Discontinuous stochastic processes model the dynamics of such random evolutions. The case when the evolution forgets its past leads to the Markov property of the stochastic process. Markov processes are, through their infinitesimal generators, related to functional analysis and partial differential equations. The infinitesimal generator of a discontinuous Markov process is a non-local, integro-differential operator. The goal of this project is to study certain classes of discontinuous stochastic processes and non-local operators, their potential theory and stability theory, and connection to partial differential equations. Specifically, our objectives are to investigate the following problems: (1) Study a discontinuous Markov process on a bounded subset of the Euclidean space defined through its jumping kernel which takes into account the distances of points to the boundary of the subset, as well as the distance between the points. We address the question of constructing such a process and study its potential-theoretic, analytic and stability properties; (2) Extend some parts of the theory of semilinear equations for elliptic differential operators to non-local operators such as the fractional Laplacian and more general non-local operators satisfying certain weak scaling properties and to find a probabilistic representation of solutions of semilinear equations for non-local operators; (3) Apply discontinuous stochastic processes to risk theory.The research methods we use come from probability theory, potential theory, partial differential equations and functional analysis. The expected result of the proposed research is to further develop some aspects of the mathematical theory of discontinuous stochastic processes and non-local operators and to contribute to deeper understanding of the theory. ]]></summary_en></project><project>
<id>7566</id><title_hr><![CDATA[Dialogue about Radicalisation and Equality (DARE;  725349)]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3880</user_id><user_firstLast_name>Renata Franc</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-1642</code><acronim><![CDATA[]]></acronim><duration>20.09.2018 - 20.12.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Psihologija, </scie_field_hr><scie_field_en>Psychology, </scie_field_en><institution_hr><![CDATA[Institut društvenih znanosti Ivo Pilar]]></institution_hr><institution_en><![CDATA[Institute of Social Sciences Ivo Pilar in Zagreb]]></institution_en><team_members_id>25218</team_members_id><team_members_names><![CDATA[ Doktorand: Tomislav Pavlović ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>7569</id><title_hr><![CDATA[Ekstrakcija bioaktivnih biljnih sastavnica pomoću zelenih otapala – korak prema zelenim kozmeceuticima]]></title_hr><title_en><![CDATA[Bioactive plant principles extraction using green solvents - a step towards green cosmeceuticals ]]></title_en><user_id>4167</user_id><user_firstLast_name>Marijana Zovko Končić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-6504</code><acronim><![CDATA[CosmoGreen]]></acronim><duration>01.10.2018 - 28.02.2023</duration><status>Završio</status><financ_value>139.204,19 eur</financ_value><scie_area_hr>Prirodne znanosti, Biomedicina i zdravstvo, </scie_area_hr><scie_area_en>Natural sciences, Biomedicine and health sciences, </scie_area_en><scie_field_hr>Kemija, Farmacija, </scie_field_hr><scie_field_en>Chemistry, Pharmaceutical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Farmaceutsko-biokemijski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Pharmacy and Biochemistry]]></institution_en><team_members_id>23855, 23854, 6966, 20361, 22753, 3925, 23856, 3915, 23972, 26076, 858443, 861756, 6482, 18925, 3946, </team_members_id><team_members_names><![CDATA[Vassilios Roussis, Efstathia Ioannou, Lovorka Vujić, Monika Barbarić, Jasna Jablan, Suzana Inić, Biljana Božin, Mario Jug, Petar Ciganović, Marina Jurić, Lejsa Jakupovic, Michal Tomczyk, Jasna Prlić Kardum, Anamarija Mitar, Marijan Marijan, ]]></team_members_names><keywords_hr><![CDATA[Anti-aging, fibroblasti, izolacija vođena bioaktivnošću, kozmeceutici, optimizacija ekstrakcije, zelena otapala]]></keywords_hr><keywords_en><![CDATA[Anti-aging, bioactivity guided isolation, cosmeceuticals, extraction optimization, fibroblasts, green solvents]]></keywords_en><summary_hr><![CDATA[Mnogobrojne biljne sastavnice mogu utjecati na različite mete u ljudskom organizmu, uključujući stanice kože i ekstracelularni matriks. Na taj način one mogu djelovati ne samo na izgled nego i na zdravlje ovog važnog organa. Zbog toga se biljni ekstrakti često koriste u izradi takozvanih &#39;&#39;kozmeceutika&#39;&#39;, proizvoda za koje se smatra da imaju značajke kozmetike i lijekova. Prirodno porijeklo sastavnica takvih proizvoda, što uključuje i aktivne i pomoćne tvari, vrlo je poželjno. Stoga bi otapala koja se koriste za ekstrakciju biljnog materijala trebala biti prirodnog porijekla, biorazgradiva i netoksična. Nadalje, postupak ekstrakcije trebao bi biti usmjeren k povećanju sadržaja aktivne tvari u ekstraktima. Također je poželjno da otapalo ne bude samo pasivni nosač aktivne tvari nego i da učinkovito povećava njezinu djelotvornost. U sklopu projekta biti će priređena serija ekstrakata kopnenih i morskih organizama. Izolirat će se njihove aktivne sastavnice te odrediti njihova struktura. Biološka aktivnost ekstrakata bit će detaljno ispitana korištenjem više enzimskih testova te ispitivanja na stanicama. Odredit će se optimalni uvjeti ekstrakcije aktivnih tvari. Rezultati projekta bit će primjenjivi u razvoju kozmetičkih i dermatoloških proizvoda. Imajući na umu da će dio biljnog materijala koji će se koristiti u istraživanju biti dobiven iz otpadne biomase, rezultati će imati značajan ekonomski i ekološki potencijal  za proizvodnju kozmetike iz obnovljivih izvora. ]]></summary_hr><summary_en><![CDATA[Numerous plant secondary metabolites can affect multiple targets in human body, including skin cells and extracellular matrix. In this way, they can influence not only look, but also overall health of this important organ. For this reason plant extracts are often part of so-called “cosmeceuticals”, products combining the principles of cosmetics and drugs. Natural origin of such products&#39; ingredients, including both the active principles and the excipients, is highly valued. Therefore, the solvent used for the extraction of plant material should be of natural origin, biodegradable and non-toxic. Furthermore, the extraction process should be aimed at increasing the content of the active ingredient in the extract. Finally, it is desirable that the solvent is not only a passive carrier of the bioactive molecule but that it effectively enhances its desired activity. In the course of the project, a series of extracts from both terrestrial and marine organisms using non-toxic solvents of natural origin will be prepared. Their active constituents will be isolated, their structure determined and the biological activity thoroughly tested using several enzyme and cellular assays. Optimal conditions for the &#39;&#39;green&#39;&#39; extraction of active principles will be determined. The findings of this project will be applicable in development of cosmetic and dermatological products. Having in mind that the part of plant material used for the extraction will be obtained from waste biomass, the results will have a significant economical and ecological potential for production of cosmetics from renewable sources.]]></summary_en></project><project>
<id>7573</id><title_hr><![CDATA[Umrežavanje glazbom: promjene paradigmi u „dugom 19. stoljeću“ – od Luke Sorkočevića do Franje Ks. Kuhača]]></title_hr><title_en><![CDATA[]]></title_en><user_id>7808</user_id><user_firstLast_name>Vjera Katalinić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-8641</code><acronim><![CDATA[NETMUS19]]></acronim><duration>01.08.2018 - 01.10.2021</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Znanost o umjetnosti, </scie_field_hr><scie_field_en>Arts, </scie_field_en><institution_hr><![CDATA[Hrvatska akademija znanosti i umjetnosti]]></institution_hr><institution_en><![CDATA[Croatian Academy of Sciences and Arts]]></institution_en><team_members_id>19469</team_members_id><team_members_names><![CDATA[ Doktorand: Sara Ries ]]></team_members_names><keywords_hr><![CDATA[umrežavanje, glazba, dugo 19. stoljeće, Luka Sorkočević, Franjo Ksaver Kuhač, korespondencija, dnevnik]]></keywords_hr><keywords_en><![CDATA[networking, music, long 19th century, Luka Sorkočević, Franjo Ksaver Kuhač, correspondence, diary]]></keywords_en><summary_hr><![CDATA[Umrežavanje glazbom u „dugom 19. stoljeću“ proučavat će se komparativno na tri tematska kruga: 1) Boravak Luke Sorkočevića (1734-1789) u Beču (1781-82) i njegov dnevnik koji pruža uvid u krug istaknutih političkih, kulturnih i intelektualnih ličnosti i u sustav provođenja politike Dubrovačke Republike; 2) mapiranje dolazaka i nastupa inozemnih putujućih opernih družina i solista u Zagrebu sredinom 19. stoljeća od „prve nacionalne opere“ - Ljubavi i zlobe V. Lisinskoga (1846) do pokretanja stalne nacionalne opere u zagrebu i Zajčeva Mislava (1870); 3) obrazovna i istraživačka povezivanja F. Ks. Kuhača (1834-1911) sa skladateljima, muzikografima i melografima srednje i jugoistočne Europe kroz prizmu korespondencije te objavljene dokumentacije i njegovih radova. Uz arhivska i terenska istraživanja komparativno će se analizirati izvori sačuvani u Hrvatskoj i inozemstvu (Italija, Austrija, Mađarska, Češka, Slovačka, Poljska, Srbija, Bugarska). Istraživanja će rezultirati pojedinačnim člancima i kritičkim izdanjima Sorkočevićeva dnevnika te druge i treće knjige (1864-1872) korespondencije od 13 sačuvanih iz Kuhačeve ostavštine.]]></summary_hr><summary_en><![CDATA[Networking through music in the „long 19th century“ will be comparatively investigated within three thematic areas: 1) The sojourn of Luka Sorkočević (1734-1789) in Vienna in 1781-82 and his diary which gives insight into the circle of outstanding political, cultural and intellectual figures and into the functioning of the politics led by the Dubrovnik Republic; 2) maping of arrivals and performances of foreign itinerant opera companies and soloists in Zagreb in the mid-19th century, from „first national opera“ - Lisinski&#39;s Love and malice (1846) - to the foundation of the permanent opera ensemble in Zagreb and Zajc&#39;s opera Mislav  (1870); 3) educational and research connections of Franjo Ksaver Kuhač (1834-1911) with composers, musicographers and melographers from the central and south-eastern Europe through his correspondence and published documents and his publications. Beside archival and filed research, a comparative analyses of sources preserved in Croatia and abroad (Italy, Austria, Hungary, Czechia, Slovakia, Poland, Serbia, Bulgaria) will be conducted. The research will result with articles and critical editions of Sorkočević&#39;s diary, as well as the second and third book of correspondence (1864-1872) out of 13 preserved in the legacy F. Ks. Kuhač.]]></summary_en></project><project>
<id>7577</id><title_hr><![CDATA[Dinamička i ergodička svojstva preslikavanja na plohama]]></title_hr><title_en><![CDATA[Dynamical and ergodic properties of maps on surfaces]]></title_en><user_id>2870</user_id><user_firstLast_name>Sonja Štimac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-7491</code><acronim><![CDATA[DEPOMOS]]></acronim><duration>01.11.2018 - 31.10.2022</duration><status>Završio</status><financ_value>85.871,66 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>5838, 740, 20035, </team_members_id><team_members_names><![CDATA[Siniša Slijepčević, Vjekoslav Kovač, Kristijan Kilassa Kvaternik, ]]></team_members_names><keywords_hr><![CDATA[Teorija tiještenja, topološka entropija, atraktor, metrička entropija, tvist difeomorfizam, ergodički teorem, Heisenbergova grupa]]></keywords_hr><keywords_en><![CDATA[The kneading theory, topological entropy, attractor, metric entropy, twist diffeomorphism, ergodic theorem, Heisenberg group]]></keywords_en><summary_hr><![CDATA[Teorija dinamičkih sustava i posebno studija kaotičnih sustava bila je jedan od važnih otkrića u znanosti 20-og stoljeća. Geometrijske i kvalitativne tehnike iz dinamičkih sustava uspješno se primijenjuju na niz važnih nelinearnih problema, od fizike i kemije do ekologije i ekonomije. Razvoj snažnih računala i kompjutorske grafike pokazao je da dinamika niskodimenzionalnih sustava može biti istodobno lijepa i komplicirana.Cilj predloženog projekta je proučavanje određenih klasa tih lijepih i kompliciranih niskodimenzionalnih kaotičnih dinamičkih sustava. Točnije, naši ciljevi su istražiti sljedeće probleme: (1) Lozijevski atraktori. Planiramo istražiti dinamička svojstva lozijevskih preslikavamnja i topološka svojstva lozijevskih atraktora. (2) Tvist difeomorfizmi na cilindru koji čuvaju površinu. Postoje brojna fundementalna ergodsko-teoretska pitanja za te klase preslikavanja koja još nisu odgovorena, posebice vezano uz jake ocjene topološke i metričke entropije te Lyapunovljevih eksponenata. Planiramo dalje razvijati varijacione metode koje adresiraju te probleme.(3) Ergodička teorija na Heisenbergovoj grupi. Namjeravamo izvesti ocjene koje daju kvantitativnu informaciju o konvergenciji po normi dvostrukih ergodičkih usrednjenja obzirom na dva toka/preslikavanja koji/koja generiraju Heisenbergovu grupu. To će biti ostvareno proučavanjem svojstava lijevo-invarijantnih tokova i pripadnih analitičkih usrednjenja na neprekidnoj Heisenbergovoj grupi, koja je već zanimljiva sama za sebe. Metode istraživanja koje namjeravamo koristiti dolaze iz ergodske teorije, simboličke i hiperboličke dinamike, teorije kontinuuma, topologije i analize. Očekivani rezultati su daljnji razvoj nekih aspekata niskodimenzionalnih dinamičkih sustava. Rezultati istraživanja bit će napisani u 10-12 radova objavljenih u vodećim svjetskim matematičkim časopisima.]]></summary_hr><summary_en><![CDATA[The theory of dynamical systems and especially the study of chaotic systems has been one of the important breakthroughs in science in the 20th century. Scientists have been able to apply the geometric and qualitative techniques from dynamical systems to a number of important nonlinear problems ranging from physics and chemistry to ecology and economics. Development of powerful computers and computer graphics has shown that the dynamics of low-dimensional systems can be at once beautiful and complicated. The goal of the proposed project is to study certain classes of these beautiful and complicated low-dimensional chaotic dynamical systems. More precisely, our objectives are as follows: (1) The Lozi-like maps. We plan to investigate dynamical properties of the Lozi-loke maps and topological properties of the Lozi-like attractors. (2) The area-preserving twist diffeomorphisms on a cylinder. There is a number of fundamental ergodic theoretical questions still unanswered for these classes of maps, in particular related to obtaining sharp bounds on topological and metric entropy and Lyapunov exponents. We plan to develop further variational techniques to address these problems. (3) Ergodic theory on the Heisenberg group. We plan to derive estimates providing quantitative information on the norm convergence of double ergodic averages with respect to two flows/maps generating the Heisenberg group. This will be achieved by investigating properties of left-invariant flows and the corresponding analytical averages on the continuous Heisenberg group, which is an interesting structure on its own. The research methods we plan to use come from ergodic theory, symbolic and hyperbolic dynamics, continua theory, topology and analysis. The expected results are to further develop some aspects of the low-dimensional dynamical systems. The results of the research will be written in 10 – 12 papers published in leading international mathematical journals.]]></summary_en></project><project>
<id>7579</id><title_hr><![CDATA[Svjetlo na molekulama: istraživanje spregnute elektronske i nuklearne dinamike]]></title_hr><title_en><![CDATA[]]></title_en><user_id>2848</user_id><user_firstLast_name>Nađa Došlić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-4034</code><acronim><![CDATA[LightMol]]></acronim><duration>05.09.2018 - 04.12.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>25276</team_members_id><team_members_names><![CDATA[ Doktorand: Tomislav Piteša ]]></team_members_names><keywords_hr><![CDATA[neadijabatska dinamika, fotoelektronska spektroskopija, DNA, mikrosolvatacija, višekromoforni sustavi]]></keywords_hr><keywords_en><![CDATA[nonadiabatic dynamics, photoelectron spectroscopy, DNA, microsolvation, multichromophore systems]]></keywords_en><summary_hr><![CDATA[Mogućnost praćenja elektronskih i strukturnih transformacija kroz koje molekulski sustav prolazi nakon apsorpcije svjetla je dugo sanjani san. Njegovo je ostvarenje moguće samo kombinacijom teorijskih i eksperimentalnih istraživanja.  Nove spektroskopijske tehnike temeljene na interakciji s visokofrekventnim zračenjem dopuštaju istraživanje molekulske strukturne dinamike na dosad neviđenoj razini detaljnosti.  Posebno se vremenski razlučena fotoelektronska spektroskopija (TRPES) etablirala kao vodeća tehnika u tom polju. Međutim, interpretacija TRPES eksperimenata zahtijeva naprednu razinu teorije. Teorijske metode za računanje TRPES opservabli moraju biti dovoljno točne da se može uspostaviti izravna veza između strukture molekule i eksperimentalne opservable. One također moraju biti efikasne, jer simulacija vremenski razlučenih eksperimenata zahtijeva račune za stotine ili čak za tisuće molekulskih gemoetrija. Ciljevi ovog projekta su (i) poboljšanje numeričke efikasnosti računanja fotoionizacijskih opservabli. Naš cilj je učiniti vrijeme potrebno za računanje vrlo točnih udarnih presjeka i parametara asimetrije usporedivim s vremenom računanja dinamike u pobuđenim stanjima.;(ii) razvoj metoda za pouzdanije simulacije nedijabatske molekulske dinamike. To se prvenstveno odnosi na uključivanje u simulacije nuklearnih kvantnih efekata. Relaksacija pobuđenih stanja u biomolekulama često odvija  eliminacijom vodika kojeg simulacije neadijabatske dinamike često “ne vide” .(iii) poboljšanje numeričke efikasnost simulacija neadijabatske molekulske dinamike prijenosom dijela računa na grafičke procesore (GPU). To će nam omogućiti istraživanje dinamike složenih  struktura kao što su hidratirane nukleobaze, vertikalno i horizontalno povezane DNA baze.Mišljenja smo da uz korištenje naprednih algoritamskih tehnika ostvarenje sna i nije tako daleko.]]></summary_hr><summary_en><![CDATA[The possibility to follow the electronic and structural transformations that a molecular system undergoes after light absorption is a long-standing dream. The realization of this dream is possible only through a joint theoretical and experimental effort. New spectroscopic techniques based on interaction with high frequency radiation permit the investigation of molecular structural dynamics at an unprecedented level of detail. In particular, time-resolved photoelectron spectroscopy (TRPES) has emerged as the leading technique in this field. However, the interpretation of TRPES experiments requires advanced theory. Theoretical methods for calculating TRPES observables need to be accurate, so that a direct link between the structure of a molecule and the experimental observable can be established. They also need to be efficient because the simulation of time-resolved experiments requires calculations to be performed for hundreds or even thousands of molecular geometries. In order to meet these conditions, which are at the very heart of this project, advances on several fronts will be made: (i) we will improve the numerical efficiency of the computation of photoionization observables. Our goal is to make the numerical effort required for the computation of very accurate cross sections and asymmetry parameters comparable to the one for the computation of the excited state dynamics; (ii) better-quality methods for nonadiabatic molecular dynamics will be developed by the inclusion of nuclear quantum effects in simulations; (iii) we will improve the numerical efficiency of nonadiabatic molecular dynamics simulations by porting part of the calculation to graphical processor units (GPU). This will allow us to explore the dynamics of complex structures such as hydrated nucleobases, stacked and paired DNA bases.We feel that with advanced algorithmic techniques the dream is not so far away.]]></summary_en></project><project>
<id>7580</id><title_hr><![CDATA[Anisakis kao kancerogen: Izazov rušenja Lancetovog mita ili otkrivanje prave istine]]></title_hr><title_en><![CDATA[Anisakis as a carcinogen: Daring to bust Lancet&#39;s myth or revealing its true colours]]></title_en><user_id>132</user_id><user_firstLast_name>Ivona Mladineo</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-8490</code><acronim><![CDATA[AnisCar]]></acronim><duration>01.04.2019 - 31.03.2023</duration><status>Prekinut</status><financ_value>199.084,21 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Veterinarska medicina, </scie_field_hr><scie_field_en>Veterinary medicine, </scie_field_en><institution_hr><![CDATA[Institut za oceanografiju i ribarstvo]]></institution_hr><institution_en><![CDATA[Institute of Oceanography and Fisheries]]></institution_en><team_members_id>23685, 23713, 19279, 4601, 23767, 13683, 23921, 1238, 1127, 28773, 5343, </team_members_id><team_members_names><![CDATA[Concetta Maria Messina, Binh Dang Thuy, Violeta Šoljić, Mirela Petrić, Anamarija Vrbatović, Jerko Hrabar, Igor Azinovic, Diana Nonković, Vedran Poljak, Tina Pavelin, Svjetlana  Cvjetan Čutura, ]]></team_members_names><keywords_hr><![CDATA[Anisakis pegreffii, kancerogenost, zoonoza, nametnik, CTA]]></keywords_hr><keywords_en><![CDATA[Anisakis pegreffii, carcinogenicity, zoonosis, parasite, CTA]]></keywords_en><summary_hr><![CDATA[AnisCar obuhvaća temeljna istraživanja usmjerena prema otkrivanju kancerogenog potencijala ličinke zoonotičnog oblića Anisakis u ljudi. Danas je poznato da je više od 20% bolesti raka u zemljama u razvoju uzrokovano infekcijama, ali je manje poznata činjenica da infekcija helmintima može imati slične posljedice. Međunarodna agencija za istraživanje raka (IARC) zasada smatra da su jedino tri vrste metilja odgovorne za izazivanje raka u ljudi: Schistosoma haematobium, Opisthorchis viverrini i Clonorchis sinensis. Pred gotovo tri desetljeća prestižni časopis Lancet je objavio rad u kojem se spekuliralo o mogućnosti da pripadnici roda Anisakis mogu djelovati kao potencijalni kancerogeni, dok se tek u nekoliko nedavnih studija dokazala kolokalizacija raka probavila i infektivne Anisakis ličinke. Iako još uvijek nije razjašnjeno jesu li dvije etiologije, anisakijaza i karcinom, povezane ili slučajna pojava, u svim opisanim slučajevima je zapaženo da neoplazija i ličinka dijele područje zahvaćeno kroničnom upalom. Nadalje, nekoliko opreznih pokušaja interpretacije interakcije između Anisakisa i stanica domaćina je potaklo ideju da kronična infekcija ličinkom može biti okidač za intestinalnu kancerogenezu. Nastavljajući se na prethodni HRZZ projekt, cilj AnisCar je rasvijetliti mehanizme toksičnog i kancerogenog potencijala Anisakis ličinke u in vivo i in vitro mišjem modelu, u usporedbi s dva poznata kancerogena, azijskim metiljima O. viverrini i C. sinensis. Metodologija obuhvaća izolaciju ukupnih proteina iz tri vrste nametnika, određivanje njihove citotoksičnosti u BALB/c 3T3 mišjim fibroblastima, tesiranje potencijala transformacije BALB/c 3T3 stanica, te konačno dokazivanje tumorskog rasta u miševa nakon aplikacije BALB/c 3T3 transformiranih stanice. Ova saznanja će utjecati na osnove parazitologije pružajući uvid u nove osobine oblića, te će dati na važnosti i težini ovoj bolesti koja se kod ljudi često pogrešno dijagnosticira i slabo prijavljuje na području Europe. ]]></summary_hr><summary_en><![CDATA[AnisCar is a fundamental research directed toward better understanding of carcinogenic potential of zoonotic nematode larvae Anisakis in men. Today more than 20% of cancers in the developing world are caused by infections, but less perceived is the fact that infection with helminths can have similar consequences. The International Agency for Research on Cancer so far considers only three species of trematodes, Schistosoma haematobium, Opisthorchis viverrini and Clonorchis sinensis, responsible for helminth-induced human cancer. Almost three decades ago, prestigious journal Lancet published a view speculating on the possibility that Anisakis could also act as potential carcinogen, and only recently a number of studies have co-localised intestinal cancers and Anisakis larvae. Even though it is still unclear if two aetiologies, anisakiasis and carcinoma are related or just accidental incidence, all reported cases observed neoplasia and embedded larvae sharing the common site affected by chronic inflammation. In addition, a few timid assessments of Anisakis-host cells interactions encouraged the idea that chronic larval infection could represent a trigger for intestinal carcinogenesis. Capitalising on previous HRZZ project, AnisCar objective is to divulge mechanisms of Anisakis toxic and carcinogenic potential in vivo and in vitro mouse model, in relation to two known helminth carcinogens, Asian trematodes O. viverrini and C. sinensis. Methodology encompasses the isolation of crude extracts from three parasites; determination of its cytotoxicity in BALB/c 3T3 fibroblast mice cells; testing of transformation potential of BALB/c 3T3 cells; and finally evidencing tumour growth in mice after application of BALB/c 3T3 transformed cells. Contributing with this knowledge, we will affect the fundamental parasitology by gaining insight in new traits of nematodes and contribute to seriousness of the disease that in men throughout the Europe is misdiagnosed and underreported.]]></summary_en></project><project>
<id>7581</id><title_hr><![CDATA[Umjetnost i država u Hrvatskoj od prosvjetiteljstva do danas]]></title_hr><title_en><![CDATA[Art and the State in Croatia from the Enlightenment to the Present]]></title_en><user_id>3499</user_id><user_firstLast_name>Dragan Damjanović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-9364</code><acronim><![CDATA[ASCEP]]></acronim><duration>15.10.2018 - 14.04.2023</duration><status>Završio</status><financ_value>79.633,69 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Povijest umjetnosti, </scie_field_hr><scie_field_en>Art history, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>4794, 23503, 23689, 4206, 4195, 23276, 23484, 4143, 4446, 4416, 4554, 4475, 23485, 23307, 865209, </team_members_id><team_members_names><![CDATA[Frano Dulibić, Ivan Kokeza, Matea Brstilo Rešetar, Sandi Bulimbašić, Zvonko Maković, Jasmina Nestić, Patricia Počanić, Željka Miklošević, Lovorka Magaš Bilandžić, Silvija Lučevnjak, Jasminka Najcer Sabljak, Sanja  Zadro, Marina Bregovac Pisk, Josipa Alviž, Sanja Delić, ]]></team_members_names><keywords_hr><![CDATA[umjetnost, država, baština, politika, obrazovanje, muzeji, povijest umjetnosti, moderno i suvremeno doba]]></keywords_hr><keywords_en><![CDATA[state, art, heritage, politics, education, museums, history of art, late modern and contemporary period]]></keywords_en><summary_hr><![CDATA[Cilj je projekta Umjetnost i država u Hrvatskoj od prosvjetiteljstva do danas istražiti utjecaje koje su državne strukture vlasti imale na umjetničku produkciju te na interpretaciju umjetničkih djela i baštine.Budući da je hrvatski politički i kulturni prostor u promatranom razdoblju od kraja 18. stoljeća do osamostaljenja Hrvatske 1991., bio u sastavu raznih država (Habsburške, odnosno Austro-Ugarske Monarhije, prve i druge Jugoslavije, Kraljevine Italije, Nezavisne Države Hrvatske) istraživači na projektu pokušat će pokazati kako, koliko (i da li je) promjena državnih okvira utjecala na odnose prema umjetničkoj produkciji te kulturnoj i obrazovnoj politici uopće u polju vizualnih umjetnosti.Zbivanja u hrvatskoj umjetnosti nastojat će se kontekstualizirati sa situacijom u susjednim zemljama, odnosno s područjima kojima je Hrvatska politički pripadala te stoga uključuje brojna terenska, arhivska, muzejska i bibliotečna istraživanja. Istraživački ciljevi unutar projekta mogu se podijeliti u dvije osnovne skupine – istraživanje utjecaja države na sva polja likovnog stvaralaštva putem narudžbi, subvencija i kontrole nad umjetničkom produkcijom, te istraživanje utjecaja države na procese stvaranja i očuvanja umjetničke baštine kao i na formalno i neformalno obrazovanje u području likovnih umjetnosti.Uz voditelja u projekt je uključeno 14 istraživača, od kojih je 8 u statusu doktoranda ili postdoktoranda kojima je ovaj projekt od osobite važnosti za daljnju izgradnju znanstvenih karijera. Uključivanjem istraživača iz baštinskih institucija (muzeja, konzervatorskih odjela) nastojat će se produbiti međuinstitucionalna suradnja i omogućiti višedimenzionalno sagledavanje složenih odnosa države prema umjetnosti.Rezultate projekta predstavljat će radovi u časopisima, knjige, zbornici, katalozi i druge publikacije, izložbe, izlaganja na znanstvenim skupovima, a članovi projekta namjeravaju organizirati i dva znanstvena skupa te radionicu.]]></summary_hr><summary_en><![CDATA[The project Art and the State in Croatia from the Enlightenment to the Present aims to explore influences of the state regime on art production and interpretation of artworks and artistic heritage.Since the Croatian cultural and political space in the period from the late 18th century to 1991 formed part of different states (Austro-Hungarian Empire, first and second Yugoslavia, Independent State of Croatia, Kingdom of Italy), the project researchers will attempt to show the degree and nature of the impact the state-based bodies exerted on artistic production and cultural and educational policies related to visual arts.Croatian art will be contextualized with artistic developments in the neighboring countries or the areas of political association with Croatia, due to which the implementation of the project entails numerous field researches (urban space, museums, libraries, archives).In terms of its goals, the project is divided into two major groups of activities – research on the impact of the state on different areas of artistic production through commissions, grants and censorship, and the impacts on the process of artistic heritage production and care and on formal and informal education in the field of visual arts.In addition to the principal investigator the project includes 14 researchers (2 doctoral students and 6 postdoctoral researchers) for whom this project presents an opportunity for academic career development. By engaging researchers from heritage institutions (museums and conservation departments), the project contributes to the promotion of inter-institutional cooperation and ensures multidimensional views on intricate relationships between art and the state.Project results will be published in journals, books, proceedings, catalogues and the like, as well as through exhibitions and conferences. The team plans to organize two project-related scientific conferences and a workshop.]]></summary_en></project><project>
<id>7582</id><title_hr><![CDATA[Književne revolucije]]></title_hr><title_en><![CDATA[Literary Revolutions]]></title_en><user_id>19523</user_id><user_firstLast_name>Marina  Protrka Štimec</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-7020</code><acronim><![CDATA[LIRE]]></acronim><duration>12.11.2018 - 11.05.2023</duration><status>Završio</status><financ_value>27.745,57 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filologija, Interdisciplinarne humanističke znanosti, </scie_field_hr><scie_field_en>Philology, Interdisciplinary humanities, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>5581, 6591, 23960, 19189, 19165, 27498, </team_members_id><team_members_names><![CDATA[Zrinka Božić Blanuša, Aleksandar Mijatović, Ana Tomljenović, Zvonimir Glavaš, Andrea Milanko, Mirela Dakić, ]]></team_members_names><keywords_hr><![CDATA[književnost, revolucije, avangarda, književni kanon, estetska autonomija, emancipacija, zajednica]]></keywords_hr><keywords_en><![CDATA[literature, revolutions, Avangarde, literary canon formation, esthetic autonomy, emantipation, community]]></keywords_en><summary_hr><![CDATA[Projektom će se istraživati naslijeđe avangarde u književnom i društvenom polju, složena međuovisnost estetske autonomije i emancipacijskih praksi. Taj će se problemski sklop analizirati s obzirom na: 1. plan na kojemu se književnost odvija (poetički, estetički, politički, ideološki), 2. logiku temporalnosti – odnos prema prošlosti i tradiciji, 3. ideologiju – građansku, nacionalne narative i projekte političkih zajednica, te na 4. dominantni tip racionalnosti, tj. prevladavajuće simboličke prakse.U prvom koraku ćemo nastaviti tradiciju istraživanja avangarde kao književnopovijesnog fenomena, ali tako da je kritički promotrimo u svjetlu novih metodologija i pristupâ te u širem srednjoeuropskom i južnoslavenskom kontekstu. Cilj projekta je razviti temeljna znanja – teorijsku i metodološku paradigmu za razumijevanje i analizu koncepta književnih revolucija, utemeljenih u estetskoj autonomiji književnosti. Ispitat ćemo kako su revolucije, Francuska i Oktobarska, generirale promjene u književnom polju i kako je književno polje odredilo razumijevanje političkih pojmova zajednice i povijesnih procesa.  Pri tome ćemo identificirati pretpostavke koje su omogućile avangardnu književnu revoluciju te opisati tekstualnu mrežu simboličkih i političkih praksi koje zajednički tvore revolucionarni, emancipatorski potencijal književnosti, posebno kanonskih autora „malih“ književnosti poput hrvatske čiji je status dodatno složen i slabo istražen zbog političkih otpora koji su se vodili na književnom polju, odvraćajući pozornost istraživača s otpora forme (Krleža, Begović, Desnica). Istražit ćemo kako se prema dominantnim tekstualnim strategijama odnosi subverzivno „žensko pismo“ (Cixious), po definiciji manjinsko, a kako feministička teorija i književna kritika, a posebno ona nastala na psihoanalitičkim temeljima. Istraživačke aktivnosti rezultirat će  teorijskom i metodološkom platformom za istraživanje avangarde te novim opisom poetike kanonskih autora hrvatskog modernizma.]]></summary_hr><summary_en><![CDATA[The research project will investigate the avant-garde literary and social legacy, with special emphasis on its intricate interrelations between aesthetic autonomy and emancipation practices, to be analyzed with respectto: i) the emergence of literature and its spheres of influence (poetic, aesthetic, political and ideological); ii) a particular logic of temporality, i.e. how newly emerged literature relates to its past and tradition; iii) ideology, i.e. national narratives, political communities, and citizenship; iv) the dominant mode of rationality, i.e. prevalent symbolic practices.Innovation in approach is in critical examination of literary avant-garde in the light of contemporary methodologies and approaches, as well as in taking a wider context into consideration (Central European and South Slavic). This will help develop fundamental knowledge, i.e. theoretical and methodological paradigm for understanding and analysis of literary revolutions with their basis in the idea of aesthetic autonomy. We will be focusing on how the French and October Revolutions induced changes in literary field and how literary field marked out the understanding of political notions. Special attention will be paid to the status of &#39;&#39;minor&#39;&#39;literature such as Croatian, even more complex and critically underexamined case due to political resistance that took place on literary field, diverting interest of literary scholars and critics from the resistance of form (Krleza, Begovic, Desnica). We will also encompass &#39;&#39;écriture féminine&#39;&#39; (Cixous), by definition minor and subversive, how it positions itself towards the patriarchal yet dominant textual strategies and concepts, along with feminist literary theory and criticism, especially its he latter&#39;s psychoanalytically informed branch. All this will offer an innovative description of poetics of canonical writers of Croatian modernity and invention of a theoretical and methodological study platform for critical research of the avant-garde.]]></summary_en></project><project>
<id>7584</id><title_hr><![CDATA[Zemljovid atomskih jezgara - neutronski bogata strana]]></title_hr><title_en><![CDATA[Neutron Rich Side of the Nuclear Landscape]]></title_en><user_id>166</user_id><user_firstLast_name>Suzana Szilner</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-1257</code><acronim><![CDATA[NeRiS-Land]]></acronim><duration>01.12.2018 - 30.05.2024</duration><status>Završio</status><financ_value>191.253,57 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>255, 414, 4019, 163, 185, 193, 21303, 23001, 257, 865037, 865036, </team_members_id><team_members_names><![CDATA[Mile Zadro, Neven Soić, Matko Milin, Igor Gašparić, Milivoj Uroić, Deša Jelavić Malenica, Nikola Vukman, Deni Nurkić, Tea Mijatović, Luka Palada, Josipa Diklić, ]]></team_members_names><keywords_hr><![CDATA[struktura atomskih jezgara, nuklearne reakcije, nukleonske korelacije, sparivanja nukleona, nuklearni klasteri]]></keywords_hr><keywords_en><![CDATA[nuclear structure, nuclear reactions, neutron-rich nuclei, nucleon-nucleon correlations, nuclear pairing, nuclear clustering]]></keywords_en><summary_hr><![CDATA[Vrlo nedavno opažanje spajanja dvaju neutronskih zvijezda, koje nedvojbeno povezuje konkretan astronomski događaj s proizvodnjom teških elemenata, pobudilo je posebnu pažnju nuklearnih i astrofizičkih zajednica. Doprinosi u vidu novih nuklearnih podataka nužni su, uz poznavanje zvjezdanih parametara, za razumijevanje podrijetla elemenata u svemiru i određivanje stvarnog puta odvijanja procesa brzog neutronskog uhvata u karti nuklida, kao i eksplozivne nukleosinteze lakih jezgara. Predloženi projekt ima za cilj rješavanje ključnih nepoznanica na neutronskoj strani nuklearnog zemljovida upotrebom specijaliziranih akceleratorskih postrojenja i unaprijeđenih detektorskih sustava velikih dimenzija u prikupljanju visoko-kvalitetnih podataka, a uz fokus na metode produkcije jezgara bogatih neutronima i pobuđivanja egzotičnih nuklearnih struktura. Novi podaci poslužit će i za testiranje naprednih teorijskih modela i time unaprijediti razumijevanje nuklearne interakcije i još uvijek neutvrđene veze između nuklearne strukture i dinamike s teorijom jake nuklearne sile koja veže neutrone i protone.Najveći dio predloženih mjerenja izvršit će se na vrhunskim međunarodnim akceleratorskim postrojenjima za stabilne i radioaktivne ionske snopove, korištenjem najsuvremenijih detekcijskih sustava. U prikladnim slučajevima mjerenja će se provoditi i na ubrzivačima IRB-a. Ovaj projekt ujedinjuje hrvatsku zajednicu eksperimentalnih niskoenergijskih nuklearnih fizičara i jača njen položaj na karti europske nuklearne fizike. Znanstvenici koji sudjeluju u projektu bili su glasnogovornici brojnih eksperimenata na međunarodnim postrojenjima, imaju veliko iskustvo u nuklearnim eksperimentalnim istraživanjima i značajan međunarodni ugled. Konačno, ovaj je projekt posve usklađen sa strateškim dokumentom dugoročnog plana ekspertne komisije za nuklearnu fiziku Europske znanstvene zaklade.]]></summary_hr><summary_en><![CDATA[The very recent observation of a merger of two neutron stars, which has unambiguously connected an astronomical event with the production of heavy elements, is presently receiving a distinctive attention of the nuclear and astrophysics community. In order to understand the origin of elements in the Universe, besides stellar parameters, inputs from nuclear physics are indispensable to define the actual path of the rapid neutron capture of heavy-mass and explosive synthesis of low-mass nuclei. The proposed project aims to address key unknowns at the neutron-rich side of the nuclear landscape by exploiting dedicated accelerator facilities and improved large-scale detection systems in acquisition of a new high quality data, focusing on the methods of  production of neutron-rich nuclei and on excitation of exotic nuclear structures. New informations will benchmark recent advanced theoretical models and thus progress the present understanding of nuclear interaction and the still missing link between the nuclear structure and dynamics and the theory of strong interaction which binds neutrons and protons.The major part of the proposed experimental work will be performed at the top international accelerator facilities for stable and radioactive ion beams by using state-of-the-art detection systems. In the well suited cases, the measurements will also be performed at the RBI accelerators. This project consolidates the Croatian community of experimental low-energy nuclear physicists and strengthens its position on the map of European nuclear physics. Senior scientists involved in this project were spokespersons of numerous experiments at international facilities, have a great experience in nuclear experimental research and a considerable international reputation. Finally, this project nicely matches the strategic community document Long Range Plan of the Nuclear Physics European Collaboration Committee of European Science Foundation.]]></summary_en></project><project>
<id>7585</id><title_hr><![CDATA[Regulacija GLI koda u tumorima ovisnim o BRAF/NRAS mutacijama]]></title_hr><title_en><![CDATA[Differential regulation of the GLI code in BRAF/NRAS driven tumors]]></title_en><user_id>19584</user_id><user_firstLast_name>Maja Sabol</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-4889</code><acronim><![CDATA[GLIcode]]></acronim><duration>01.01.2019 - 31.12.2022</duration><status>Završio</status><financ_value>132.464,53 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>23741, 942, 712, 1033, 23840, 13676, 28631, 27627, 864899, 865071, </team_members_id><team_members_names><![CDATA[Nenad Bartoniček, Vesna Musani, Petar Ozretić, Diana Trnski, Sanja Poduje, Majda Vučić, Nikolina Rinčić, Matea Kurtović, Tina Petrić, Josipa Čonkaš, ]]></team_members_names><keywords_hr><![CDATA[Signalni put Hedgehog, BRAF, NRAS, melanom, GLI]]></keywords_hr><keywords_en><![CDATA[Hedgehog signaling, BRAF, NRAS, melanoma, GLI]]></keywords_en><summary_hr><![CDATA[Signalni put Hedgehog povezan je s nastankom raznih tumora, ali točni mehanizmi djelovanja još nisu u potpunosti razjašnjeni. Fokus ovog istraživanja su tumori s mutacijama u genima BRAF ili NRAS, te njihov odgovor na inhibiciju signalnog puta Hedgehog. BRAF i NRAS nekanonički aktiviraju sva tri proteina GLI, ali točan slijed i djelovanje ovih interakcija još nisu razjašnjeni. Ovim projektom planiramo odrediti točne transkripcijske mete proteina GLI1, GLI2 i GLI3 u melanomima s različitim genetičkim podlogama: mutacijom u BRAF, mutacijom u NRAS, ili bez mutacije u ova dva gena. Stoga ćemo prvo provesti analizu ChIP-seq kako bismo odredili točne transkripcijske mete ovih proteina. Nakon toga uklonit ćemo gene za svaki od tih proteina („knock-out“) i sekvencirati transkriptome tih staničnih linija. Nakon izrade „knock-out“ linija, testirat ćemo ih nizom testova kako bismo odredili ulogu svakog od tri proteina GLI u tumorima ovisnim o BRAF/NRAS mutacijama, te kako bismo razjasnili mehanizam njihovog djelovanja u melanomima. Kombiniranim tretmanima inhibitorima signalnog puta Hedgehog i specifičnim inhibitorima BRAF/NRAS, te izradom i testiranjam staničnih linija otpornih na te lijekove, pokazat ćemo postoji li pozitivan učinak za potencijalno liječenje melanoma. Sve ove analize pokazat će nam mogu li se proteini GLI ili njihovi ciljni geni koristiti kao potencijalni biomarkeri za melanom. Na kraju, u zadnjoj godini projekta, analizirat ćemo set kliničkih uzoraka na te potencijalne biomarkere, kako bismo procijenili njihovu moguću primjenu u klinici. Ukratko, ovim projektom u planu je kompletna analiza GLI koda u melanomima ovisnim o BRAF/NRAS mutacijama, od određivanja transkripcijskih meta i pronalaženja molekularnih mehanizama do potencijalne primjene u klinici.]]></summary_hr><summary_en><![CDATA[The Hedgehog signaling pathway has been implicated in development of various tumors, but the exact roles and molecular mechanisms are still not understood. The focus of this research are the tumors harboring BRAF of NRAS mutations, and their differential response to Hedgehog pathway inhibition. Both BRAF and NRAS non-canonically activate the three GLI proteins, but the activity and interplay of this interaction in still unclear. With this project we propose to determine the exact transcriptional targets of GLI1, GLI2 and GLI3 proteins in melanoma with different genetic backrounds, either harboring a BRAF mutation, a NRAS mutation, or no mutation in these two genes. For this purpose, we will first perform ChIP-seq to determine the transcriptional targets, then knock-out each of the three GLI proteins and sequence the transcriptomes of the knock-out cell lines. After the knock-outs have been generated, a series of cell assays will be performed to determine to role of each of the three GLI proteins in BRAF/NRAS dependant tumors, and to elucidate the mechanism of their action in melanoma. Combined treatments with Hedgehog inhibitors and specific BRAF/NRAS inhibitors, followed by generation and testing of resistant cell lines, will demonstrate if there is a potential benefit in the clinical management of melanoma. All these analyses will demonstrate whether GLI proteins or their transcriptional targets can be used as potential biomarkers for melanoma. Finally, in the final year of the project, a set of clinical samples will be analyzed for these potential biomarkers to determine their possible use in the clinic. In summary, this project plans a complete analysis of the GLI code in BRAF/NRAS dependant melanoma, from determining the transcriptional targets and finding molecular mechanisms, to potential translation to the clinic.]]></summary_en></project><project>
<id>7589</id><title_hr><![CDATA[Razvoj integriranog mikrosustava za biokatalitičku proizvodnju biodizela]]></title_hr><title_en><![CDATA[]]></title_en><user_id>7049</user_id><user_firstLast_name>Bruno Zelić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-5527</code><acronim><![CDATA[DeMSy(BioPro)2]]></acronim><duration>17.09.2018 - 16.09.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Kemijsko inženjerstvo, </scie_field_hr><scie_field_en>Chemical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet kemijskog inženjerstva i tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Chemical Engineering and Technology]]></institution_en><team_members_id>25366</team_members_id><team_members_names><![CDATA[ Doktorand: Martin Gojun ]]></team_members_names><keywords_hr><![CDATA[biodizel, enzim lipaza, pročišćavanje, mikroreaktor, integrirani proces]]></keywords_hr><keywords_en><![CDATA[biodiesel, lipase, purification, microreactor, integrated process]]></keywords_en><summary_hr><![CDATA[U današnje vrijeme kada se raspoloživost i dostupnost fosilnih goriva značajno smanjuje, potreba za proizvodnjom biogoriva iz različitih obnovljivih izvora je sve izraženija. Biorazgradivost, netoksičnost i mala emisija štetnih tvari samo su neka od svojstava koja čine biodizel ekološki prihvatljivijim gorivom. Cilj ovog projekta je razviti integrirani mikrosustav za biokatalitičku proizvodnju biodizela. U tu svrhu će se proizvesti biokatalizator, enzim lipaza podrijetlom iz gljive Thermomyces lanuginosus fermentacijom na čvrstom otpadu prehrambene industrije kao supstrat, sintetizirati biodizel transesterifikacijom u kotlastom bioreaktoru i različitim mikroreaktoriskim sustavima korištenjem komercijalno dostupne i lipaze proizvedene fermentacijom na čvrstim nosačima pomoću gljive T. lanuginosus, provesti separaciju glicerola u prvoj fazi i pročišćavanje dobivenog biodizela u drugoj fazi primjenom membranske ultrafiltracije na modulima sa šupljim vlaknima kako bi proizvedeni biodizel kvantitativno i kvalitativno zadovoljio propisane norme. Kao supstrat u procesu transeterifikacije koristit će se svježe i otpadno jestivo ulje, a rezultati pokusa provedenih u različitim reaktorskim konfiguracijama će se usporediti kako bi se izabrao najpogodniji reakcijski sustav. Po prvi puta razvit će se integrirani mikroreaktorski sustav koji će na jednom čipu omogućiti kontinuiranu proizvodnju biodizela dok će se na drugom čipu odvijati kontinuirana separacija i pročišćavanje biodizela korištenjem filtera integriranih u sustav. Osim provedbe pokusa posebna pozornost će se posvetiti i razvoju matematičkog modela procesa proizvodnje biodizela u mikroreaktoru. Razvit će se 2D i 3D matematički model procesa, a rezultati simulacije matematičkog modela procesa koristit će se u svrhu boljeg razumijevanja strujanja reakcijske smjese u mikrokanalu, optimizacije procesa i uvećanja procesa.]]></summary_hr><summary_en><![CDATA[Nowadays as the availability and accessibility of fossil fuels is significantly declining, the need for the production of biofuels from various renewable sources is becoming increasingly interesting. Biodegradability, non-toxicity and low pollution emissions are merely some properties making biodiesel a more environmentally friendly fuel. The aim of this project is to develop an integrated microsystem for the biocatalytic production of biodiesel. For this purpose: (i) an enzyme lipase from the fungus Thermomyces lanuginosus will be produced on solid waste from food industry, (ii) biodiesel will be produced using transesterification reaction in a stirred-tank bioreactor and different microrector systems utilising a commercially available lipase and a lipase produced by solid-state fermentation using the fungus T. lanuginosus, (iii) separation of glycerol will be carried out in the first phase and purification of the obtained biodiesel in the second phase applying  the membrane ultrafiltration modules with hollow fibres to produce biodiesel that quantitatively and qualitatively fulfils the prescribed standards. Fresh and waste cooking oil will be used as a substrate in the transesterification process. The results of the experiments conducted in different reactor configurations will be compared in order to select the most appropriate reaction system. For the first time, an integrated microreactor system will be developed. The continuous production of biodiesel will take place in a single chip, while another chip will be used for continuous separation and purification of biodiesel using a filter integrated into the system. Special attention will be paid to the development of mathematical models for biodiesel production in a microreactor. 2D and 3D mathematical models will be developed for the processes and the results of mathematical model simulations will be used to better understand the flow of the reaction mixture, process optimization and process scale up.]]></summary_en></project><project>
<id>7590</id><title_hr><![CDATA[Imunosni mehanizmi u razvoju upale i metaboličkog sindroma u debljini]]></title_hr><title_en><![CDATA[]]></title_en><user_id>7082</user_id><user_firstLast_name>Bojan Polić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-5814</code><acronim><![CDATA[INFLAMETAB]]></acronim><duration>02.07.2018 - 01.10.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Medicine]]></institution_en><team_members_id>25199</team_members_id><team_members_names><![CDATA[ Doktorand: Ante Benić ]]></team_members_names><keywords_hr><![CDATA[Upala, Debljina, Rezistencija na inzulin, metabolički sindrom, diabetes, NASH,  stanice NK, urođeni limfociti, gamma delta limfociti T, citokini]]></keywords_hr><keywords_en><![CDATA[Inflammation, Obesity, Insuline resistance, Metabolic Syndrome, diabetes, NASH, NK cells, ILCs, gamma delta T cells, macrophages, cytokines]]></keywords_en><summary_hr><![CDATA[Pretilost je jedan od najznačajnijih i rastućih medicinskih zdravstvenih problema današnjice. Procjenjuje se da trenutno na svijetu živi više od pola milijarde debelih ljudi i  preko milijarde onih s prekomjernom težinom. Značajan broj njih oboljeva od šećerne bolesti tipa 2 (DM2) i nealkoholne bolesti masne jetre (NAFLD), koje često koegzistirjau i dijele patogene abnormalnosti debljine kao što su rezistencija na inzulin (IR), dislipidemija i hipertenzija, što su karakteristike metaboličkog sindroma. Debljina je povezana sa kroničnom sistemskom upalom niskog intenziteta za koju se smatra da je važan pozadinski uzrok IR, koja dovodi do DM2 i NAFLD. Ciljanje mehanizama upale u obje bolesti je stoga obećavajuće za buduće pristupe u terapiji. No, stvarni mehanizmi koji induciraju ili pogoršavaju upalu u debljini i uzrokuju prijelaz iz stadija pre-dijabetesa u DM2 ili iz stadija jetrene steatoze u nealkoholni steatohepatitis (NASH) su još uvjek uglavnom nejasni. Stoga je bolje poznavanje imunosnih uzroka DM2-a i NASH-a neophodno potrebno. U ovom projektu namjeravamo istražiti imunosne mehanizme koji su važni za indukciju upalnih procesa u visceralnom masnom tkivu (VAT) i jetri, te su odgovorni za razvoj DM2 i NASH. Dodatno, naš cilj je istražiti virusne faktore koji pogoršavaju IR i imaju učinak na tranziciju iz pre-dijabetesa u DM2. U ovoj studiji koristi ćemo dobro pozate mišje modele dijetom inducirane debljine (DIO), te odgovarajuće mišje mutante i druga oruđa kako bismo odgovorili na postaljena pitanja. Isto tako, usporediti ćemo eksperimentalne podatke sa podacima analize uzoraka sakupljenih od pretilih bolesnika što je također planirano projektom. Ovaj projekt povezuje imunologiju, virologiju i endokrinologiju. Istraživački tim ima dovoljno iskustva i znanja za uspješno provođenje predloženog istraživanja, te će bti sposoban stvoriti nova vrijedna i korisna saznanja o razvoju DM2-a i NASH-a. ]]></summary_hr><summary_en><![CDATA[Obesity is one of the most prominent and growing health problem of our time. It is estimated that more than a half billion of obese and another billion of overweight people live currently in the world. A significant number of them develop Diabetes Mellitus type 2 (DM2) and Non-alcoholic Fatty Liver Disease (NAFLD), which often coexist and share pathogenic abnormalities of obesity like insulin resistance (IR), dyslipidaemia and hypertension, which are features of the metabolic syndrome. Obesity is associated with a chronic systemic low-grade inflammation which is thought to be an important underlying cause of IR that leads to DM2 and NAFLD. Targeting of the underlying mechanisms of inflammation in both diseases therefore holds much promise for future therapies. However, the exact mechanisms that induce or aggravate inflammation and trigger transition from pre-diabetes to DM2 or from hepatic steatosis to non-alcoholic steatohepatitis (NASH) in obesity are still largely unclear. A better understanding of immunological causes of DM2 and NASH is therefore required.In this project we aim to investigate immune mechanisms that are important for induction of inflammatory processes in visceral adipose tissue (VAT) and liver, which are responsible for development of DM2 and NASH. In addition, our goal is to investigate viral factors that aggravate IR such as impact progression from pre-diabetes to DM2. In our study we will use well established mouse models of diet induced obesity (DIO) and appropriate mouse mutants and tools to address raised questions. We will compare experimental data with the analysis of samples collected from obese human subjects also planned in the project. Our project bridges immunology, virology and endocrinology. Our team has enough experience and expertise to drive successfully proposed research and will be able to provide valuable new insights in the development of DM2 and NASH. ]]></summary_en></project><project>
<id>7594</id><title_hr><![CDATA[Razumijevanje rimskih granica: primjer istočnog Jadrana]]></title_hr><title_en><![CDATA[Understanding Roman Borders: the Case of the Eastern Adriatic]]></title_en><user_id>7512</user_id><user_firstLast_name>Domagoj Tončinić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-4934</code><acronim><![CDATA[AdriaRom]]></acronim><duration>19.10.2018 - 18.10.2022</duration><status>Završio</status><financ_value>118.986,00 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Arheologija, </scie_field_hr><scie_field_en>Archeology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>7551, 7519, 7536, 7532, 7513, 7537, 7516, 19244, 23601, 25773, 4028, 17731, </team_members_id><team_members_names><![CDATA[Zrinka Šimić-Kanaet, Ina Miloglav, Zrinka Buljević, Sanja Ivčević, Iva Kaić, Ana Pavlović, Vinka Matijević, Miroslav Vuković, Joško Zaninović, Domagoj Bužanić, Mirjana Sanader, Mirna Vukov, ]]></team_members_names><keywords_hr><![CDATA[Istočni Jadran, Rimljani, pogranična zona, delmatski limes, rimski logori i kasteli, rimska vojska, nedestruktivne arheološke metode]]></keywords_hr><keywords_en><![CDATA[Eastern Adriatic, Romans, border zone, Delmataean limes, legionary fortresses, auxiliary forts, Roman army, non-destructive archaeology]]></keywords_en><summary_hr><![CDATA[Nakon uspjeha u Prvom punskom ratu, Rimljani su se zainteresirali za područje Grčke i Makedonije te su stoga počeli tražiti odgovarajuće prometne pravce prema tim teritorijima. Uz morski, jedini kopneni put vodio je duž istočne jadranske obale nastanjene narodima koje su Rimljani nazivali Ilirima. Rimsko osvajanje tog područja trajalo je od Prvog ilirskog rata 229. god. pr. Kr. do 9. god. po. Kr. Kako bi osigurali osvojeni teritorij između kolonija Jadera i Salone, gdje su se već smjestili prvi rimski imigranti, Rimljani su sagradili dva legijska logora i nekoliko kastela. U znanstvenoj literaturi taj je obrambeni sustav lakonski nazivan Delmatski limes, što je uzrokovalo trajnu znanstvenu raspravu. Međutim, zbog nedostatka arheoloških istraživanja koja bi podržala raspravu, još treba dovršiti sveobuhvatni pregled konteksta i značenja gore spomenute izgradnje. Namjera AdriaRom projekta jest istraživanje linije logora i kastela na tzv. Delmatskom limesu kako bi se pokazalo je li ta linija bila granica ili ne. Slijedom toga projekt bi pokušao pokazati koliku je ulogu ta granica imala u zaštiti rimskih imigranata i njihovih ekonomskih interesa. Pritom će projekt AdriaRom koristiti metodološki pristup temeljen na kombinaciji triju metoda: primjeni nedestruktivnih arheoloških istraživanja, ciljanih arheoloških iskopavanja i analizi arheoloških nalaza. Naime, ako su navedene građevne konstrukcije uistinu bile u funkciji obrane pogranične zone, to bi impliciralo da je tzv. Delmatski lime bio jedan od najranijih rimskodobnih obrambenih sustava.Ishodi predloženog projekta AdriaRom omogućit će bolje razumijevanje i potaknuti daljnje rasprave o razvoju rimskih granica, sigurnosnim i imigracijskim politikama u pograničnim zonama duž istočne obale Jadrana, kao i u rimskom svijetu općenito.]]></summary_hr><summary_en><![CDATA[Following their success in the First Punic War, the Romans became more interested in the area of Greece and Macedonia and hence sought appropriate routes to those territories. The only alternative to traveling there by the sea was using the overland route leading along the eastern Adriatic coast inhabited by the people referred to by Romans as Illyrians. The Roman conquest of this region lasted from the First Illyrian war in 229BCE until 9CE. To secure the conquered territory between the colonies of Iader and Salona, where the first Roman immigrants had already arrived, Romans built two fortresses and several forts. In the scientific literature, this defence construction was laconically called the Delmataean limes, and it has been the subject of persistent scientific discussion. However, due to insufficient archaeological research that would support the discussion, comprehensive overview of the context and meaning of above mentioned construction is yet to be completed.The aim of the AdriaRom project is to investigate the line of fortresses and forts of so called Delmataean limes in order to show whether that line was a border or not. Consequently, project aims to establish the role of the border in the protection of the safety and economic interests of Roman immigrants. In doing so, the AdriaRom project will use a methodological approach based on the combination of three methods: application of non-destructive archaeological research, targeted archaeological excavations and analysis of archaeological findings. Namely, if the stated construction was indeed intended to be a border line of a frontier zone, it would imply that so called Delmataean limes was one of the earliest Roman defence systems.The outcome of the proposed AdriaRom project will enable better understanding and drive further discussions about the development of Roman borders, security and immigration policies in frontier zones along the eastern Adriatic coast, as well as in the rest of the Roman world.]]></summary_en></project><project>
<id>7596</id><title_hr><![CDATA[Između istoka i zapada – dolina rijeke Cetine kao komunikacijska poveznica tijekom prapovijesti i antike]]></title_hr><title_en><![CDATA[]]></title_en><user_id>19187</user_id><user_firstLast_name>Helena Tomas Bakota</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-5724</code><acronim><![CDATA[CeVaS]]></acronim><duration>01.09.2018 - 01.09.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Arheologija, </scie_field_hr><scie_field_en>Archeology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>25379</team_members_id><team_members_names><![CDATA[ Doktorand: Jura Triplat ]]></team_members_names><keywords_hr><![CDATA[dolina rijeke Cetine, komunikacijski putevi, prapovijest, antika, naselja, grobnice, trgovačka razmjena, terenski pregled]]></keywords_hr><keywords_en><![CDATA[Cetina River Valley, communication pathway, prehistory, antiquity, settlement pattern, burials, trade and exchange, survey]]></keywords_en><summary_hr><![CDATA[U rano brončano doba u dolini Cetine razvila se cetinska kultura čije se odlike mogu naći po cijelom jadranskome bazenu, Malti i u Grčkoj. Stoga se s pravom može reći da je cetinska kultura predstavljala najznačajniju epohu prapovijesnoga života u dolini; ona ukazuje da su njeni nosioci mogli ostvariti kontakte s udaljenim krajevima. Rijeka Cetina, koja je u nekim svojim dijelovima plovna, pri tim je putovanjima vjerojatno služila kao važan put. Usprkos tako profitabilnoj komunikaciji koja je dolinu povezivala s Jadranom i vibrantnim Sredozemljem, razdoblja prije i nakon cetinske kulture nisu bila podjednako napredna. Jedan od ciljeva projekta jest ustanoviti koji su faktori utjecali na te varijacije kroz vrijeme. Također se namjeravaju utvrditi stupnjevi važnosti doline kao mjesta obitavališta i komunikacijskih puteva kroz prapovijesna i povijesna razdoblja. Ovi bi se ciljevi ostvarili metodom arheološkog rekognosciranja (terenskog pregleda) ciljano odabranih dijelova cetinske doline. Očekuje se da će otkriveni materijal ukazati na intenzitet naseljavanja doline u pojedinim razdobljima, ali i na intenzitet kontakata s ostalim, pogotovo udaljenijim područjima, pa će nam tako i odgovoriti na pitanja do koje je mjere u određenom razdoblju dolina bila izolirana ili pak otvorena vanjskome svijetu. Usporedbe s recentnijim epohama i događajima mogu ukazati na prednosti koje pruža život u tako plodnome okružju, ali isto tako i na nedostatke uvjetovane činjenicom da je cetinska dolina važna poveznica unutrašnjosti Balkanskoga poluotoka i Jadranskoga mora, pa je tako bila metom brojnih sila i poprištem čestih sukoba i ratova. Činjenica da je rimska legija nekoć bila stacionirana upravo u ovoj dolini (rimski vojni logor kod Trilja) govori nam da su slični problemi i sukobi život u dolini ugrožavali i u davnijoj prošlosti. Podaci prikupljeni predloženim rekognosciranjem zasigurno će pružiti bogatstvo novih arheoloških i povijesnih svjedočanstava o dolini Cetine.]]></summary_hr><summary_en><![CDATA[During the Early Bronze Age a culture developed in the Cetina Valley – the Cetina Culture – whose features over time got distributed in the Adriatic basin, Malta and Greece. That culture was a prehistoric highlight of the valley and demonstrated that its inhabitants were capable of establishing far-reaching contacts; the Cetina river, navigable at some parts, may have in that process served as a crucial communication channel. Despite this beneficial river giving access to the Adriatic sea and the vibrant Mediterranean basin, periods prior or posterior to the Cetina Culture were not equally prominent. The project seeks to explore the factors that may have influenced such a diachronic variation. Also, it aims to establish degrees of general importance of the valley as a place of habitation and communication through prehistoric and historic times. These goals will be achieved by archaeological surveying of the purposefully selected parts of the valley. The material recovered during surveying is expected to give an insight into the level of intensity of habitation of the area through time, as well as the intensity of foreign contacts (i.e. the isolation of the valley versus its receptiveness of the outside world). Comparisons to more recent periods or episodes may highlight the advantages of living in a very fertile environment, but also disadvantages caused by the role of the Cetina Valley as a transit zone from the inner Balkan peninsula to the open sea. As such, the valley has been a stage of numerous conflicts and wars. The fact that a Roman legion was once settled in the Valley (the fort of Tilurium) testifies that conflicts may have disturbed the life in the valley even in a more distant past. In brief, data obtained through a systematic archaeological survey will certainly reveal valuable archaeological and historical testimonies, but will also enhance the awareness of present local communities of the rich past of the valley.]]></summary_en></project><project>
<id>7598</id><title_hr><![CDATA[Kristalno inženjerstvo višekomponentnih metaloorganskih materijala povezanih halogenskom vezom: ususret supramolekulskom ugađanju strukture i svojstava]]></title_hr><title_en><![CDATA[]]></title_en><user_id>310</user_id><user_firstLast_name>Vladimir Stilinović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-7325</code><acronim><![CDATA[CrystEngMOM]]></acronim><duration>10.10.2018 - 09.10.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>25323</team_members_id><team_members_names><![CDATA[ Doktorand: Luka Fotović ]]></team_members_names><keywords_hr><![CDATA[Halogenska veza, metaloorganski materijali, kokristali, supramolekulska kemija, mehanosinteza]]></keywords_hr><keywords_en><![CDATA[Halogen bond, metal-organic materials, cocrystals, supramolecular chemistry, mechanosynthesis]]></keywords_en><summary_hr><![CDATA[Glavni cilj predloženog istraživanja je razvijanje općeg principa priprave višekomponentnih kristalnih materijala (kokristala) ugodivih svojstava koji sadrže metaloorganske jedinice povezane halogenskim vezama. Ciljana sinteza kokristala metaloorganskih spojeva s donorima halogenske veze predstavljala bi značajan doprinos ne samo kristalnom inženjerstvu već i kemiji materijala te supramolekulskoj kemiji krutina. Predloženo istraživanje otvorit će put ka sintezi novih supramolekulskih krutina kontrolirane strukture i dimenzionalnosti sastavljenih od metaloorganskih jedinica. Takvi materijali mogu imati magnetska, optička i električna svojstva različita od svojstava organskih supramolekulskih materijala. Uz temeljne spoznaje o povezivanju metaloorganskih spojeva halogenskim vezama, proučit će se mogućnost primjene takovog povezivanja u ciljanoj sintezi fotoosjetljivih materijala, navlast kokristala sposobnih prevoditi svjetlostnu energiju u mehaničku. Drugi dio predloženog projekta bit će dizajn i sinteza organskih višekomponentnih materijala povezanih halogenskim vezama. Do sada je izučavanje halogenskih veza bilo osjetno ograničeno jednoličnošću dostupnih donora halogenske veze. Predložena istraživačka skupina spaja iskustva pojedinih suradnika u kovalentnoj sintezi, koordinacijskoj kemiji te kristalnim inženjerstvu, što će omogućiti sintezu kako novih donora halogenske veze, tako i metaloorganskih akceptora te supramolekulskih krutina. Ti će spojevi omogućiti temeljno istraživanje sintonâ halogenske veze, te izučavanje pouzdanih načina izrade proširenih metaloorganskih materijala povezanih halogenskim vezama i mogućnosti priprave izostrukturnih metaloorganskih kokristala radi ugađanja svojstava materijala unošenjem samo malih promjena u zadanu arhitekturu kokristala.]]></summary_hr><summary_en><![CDATA[The principal aim of the proposed research is to develop the first general designs for the assembly of functional multicomponent crystalline materials (cocrystals) involving metal-organic units organized by way of halogen-bonding interactions. The controlled and deliberate synthesis of halogen-bonded cocrystals involving metal-organic building blocks remains an outstanding challenge of crystal engineering, materials science and solid-state supramolecular chemistry. The proposed research will open a path to synthesize new molecular materials with controlled 1-, 2- or 3-D architectures, involving metal-organic building blocks which are expected to provide access to new magnetic, optical and electrical properties not usually available in carbon-based supramolecular networks. In particular, besides establishing the fundamental aspects of the design of halogen-bonded metal-organic materials, the proposed research will explore the application of these designs in the synthesis of photoresponsive switching materials, specifically of cocrystals capable of transforming light into mechanical motion. Another element of the proposed research project will be the design and synthesis of purely organic halogen-bonded multi-component materials. The field of halogen-bonded cocrystals has so far been heavily limited by the poor availability of diverse halogen bond donor building blocks. A particular strength of the assembled research team lies in the extensive experience in covalent synthesis, coordination chemistry and crystal engineering, enabling the synthesis of new halogen bond donors of different bonding strength and directionality, which will be employed for the fundamental studies of halogen bonding synthons, of reliable strategies for the construction of extended halogen bonded metal-organic materials, and of isostructural metal-organic cocrystals as a means to fine-tune the properties of solid materials by introducing minute differences into a given cocrystal architecture.]]></summary_en></project><project>
<id>7604</id><title_hr><![CDATA[Arhitekture eksaskalarnih računala visokih performanci]]></title_hr><title_en><![CDATA[High Performance Computing Architectures for Exascale Era]]></title_en><user_id>5886</user_id><user_firstLast_name>Mario Kovač</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-7674</code><acronim><![CDATA[HPCExa]]></acronim><duration>01.06.2019 - 31.05.2023</duration><status>Prekinut</status><financ_value>111.212,33 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>170, 24050, 3619, 5946, 6062, 5914, </team_members_id><team_members_names><![CDATA[Josip Knezović, Alen Duspara, Daniel Hofman, Igor Čavrak, Vlado Sruk, Hrvoje Mlinaric, ]]></team_members_names><keywords_hr><![CDATA[računarstvo visokih performanci, eksaskalarno računarstvo, heterogene arhitekture, energetski učinkovito računarstvo,  akceleratori, optimizacija]]></keywords_hr><keywords_en><![CDATA[High Performance Computing, exascale computing, heterogeneous architectures, energy efficient computing, accelerators, application optimisation]]></keywords_en><summary_hr><![CDATA[Globalni izazov eksaskalarnom računarstvu visokih performanci (engl. HPC) je izgraditi sustav koji će isporučiti 50 GFlops/W. Kako bi se riješio taj problem, uporaba HPC arhitektura temeljenih na akceleratorima dobila je značajnu ulogu u proteklim godinama. Potrebna nam je nova heterogena arhitektura koja se može učinkovito prilagoditi širokom rasponu aplikacija kako bi se premostio jaz snage i performansi uz održavanje primjenjivosti. Aplikacije obično imaju skup pareto-optimalnih izvedbi koje u obzir uzimaju mnoštvo kompromisa između mjerljivih podataka kao što su performance, propusnost, moć, energija, trošak, kvaliteta usluge, ograničenja vremena i sl.HPCExa projekt ima za cilj istražiti i predložiti eksaskalarnu heterogenu arhitekturu za buduće HPC sustave koji su temeljeni na novim arhitekturalnim značajkama, kao što su Intel x86 SIMD i vektorska proširenja, nove ISA inicijative (RISC-V) i već prisutne ARM-temeljene ISA-e, zajedno s akceleratorima za odabrane računalno-intenzivne aplikacije. Projekt će istražiti kombinacije akceleratora koje uključuju: RISC CPU male potrošnje, akceleratore temeljene na GPU-u i prilagodljive akceleratore. Kako bismo ostvarili predložene ciljeve usredotočit ćemo se na dva glavna računarska uzorka: a) iznimno visoka mogućnost paralelizacije podataka, veliki i dinamičan raspon (eng. floating point) računanja na velikim multidimenzionalnim redovima s podesivom preciznosti. Ovo će pokriti većinu aplikacija koje se koriste u HPC-u, uključujući i strojno učenje. b) operacije s cijelim brojevima, manipulacijom bitova, s visokom paralelizacijom na razini proizvođač - potrošač. Ovo pokriva aplikacije transkodiranja i kriptiranja. Cilj nam je razviti studije slučaja i demonstracije provjere valjanosti za aplikacije koje se izvode na predloženom sustavu: umjetna inteligencija, video transkodiranje i 3D/4D obrada medicinskih slika u realnom vremenu. Konačno, projekt će integrirati rezultate u EPI H2020 FPA projekt.]]></summary_hr><summary_en><![CDATA[A global exascale challenge in High Performance Computing (HPC) is to build a system that would deliver 50 GFlops/W. To address this problem, the use of accelerator based HPC has gained significant importance in the last years. We need a novel heterogeneous architecture that can be efficiently customized to a wide range of applications to bridge the power/performance gap while maintaining applicability. Applications generally have a set of Pareto-optimal implementations that trade-off numerous metrics such as performance, throughput, power, energy, cost, quality of service, timing constraints etc. The HPCExa project aims to explore and propose the Exascale Heterogeneous Architectures for next-generation HPC based on novel architectural features such as SIMD and Vector extensions, new ISA initiatives such as RISC-V and already present and consolidated ARM-based ISA, together with customized and customizable accelerators for selected compute-intensive applications.  The project will Investigate the accelerator mixes comprising of: low-power RISC CPUs, GPU-based accelerators and custom designed FPGA accelerators. To make the proposed accelerators goals attainable, we will focus on two main computational patterns: a) extremely data-parallel, high-dynamic range (floating point) computation on large multidimensional arrays with tunable precision. This will cover most of classical HPC applications as well as machine learning (AI).  b) integer/fixed-point, bit-manipulation centric computation, with extreme producer-consumer parallelism. This covers transcoding and crypto application. We then aim to develop the case studies and validation demonstrators for the following applications running on the proposed Heterogeneous Computing System: Artificial Intelligence (AI), Video Transcoding (VT), and 3D/4D Real-Time Medical Image Processing (MP). Finally, the project will integrate the results into EPI H2020 FPA project.]]></summary_en></project><project>
<id>7605</id><title_hr><![CDATA[Sinteza supramolekulskih samo-udruženih nanostruktura za izgradnju naprednih funkcionalnih materijala]]></title_hr><title_en><![CDATA[Synthesis of Supramolecular Self-assembled Nanostructures for Construction of Advanced Functional Materials]]></title_en><user_id>348</user_id><user_firstLast_name>Leo Frkanec</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-6910</code><acronim><![CDATA[SUPeRNANO]]></acronim><duration>06.11.2018 - 05.11.2022</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>21266, 963, 1104, 4852, 7690, 9862, 7725, 2927, 28075, 864887, 865253, </team_members_id><team_members_names><![CDATA[Tomislav Gregorić, Tomislav Portada, Ruža Frkanec, Adela Štimac, Vladislav Tomišić, Žiga  Jakopin , Mladen Žinić, Berislav Perić, Nika Gazdek, Ivona Čipor, Marcela Šišić, ]]></team_members_names><keywords_hr><![CDATA[supramolekulska kemija,  sinteza, samo-udruge, nanostrukture, napredni funkcionalni materijala]]></keywords_hr><keywords_en><![CDATA[Supramolecular Chemistry, Synthesis, Self-assembles, Nanostructures, Advanced Functional Materials]]></keywords_en><summary_hr><![CDATA[Istraživanja u okviru predloženog projekta su interdisciplinarna s ciljem dizajna, supramolekulske  sinteze i karakterizacije novih samoorganizirajućih nano-struktura za izgradnju naprednih funkcionalnih materijala. Molekularno samoudruživanje koristi prednosti supramolekulskih interakcija (ionske, hidrofobne, van der Waals-ove, vodikove i koordinacijske veze)  koje omogućavaju konstruiranje novih nanostruktura  atraktivnih svojstava. Temeljeno na zakonitostima supramolekulske kemije, „bottom-up“ pristup za projektiranje funkcionalnih struktura u nano dimenzijama omogućuje nastajanje vrlo sofisticiranih materijala za široku primjenu. Takve strukturne karakteristike danas su dobro poznate i mogu se precizno kontrolirati kako bi se uvela i prilagodila specifična funkcionalna svojstva samoorganiziranih nanomaterijala. Nadalje, ovi sustavi pokazuju složenu morfologiju i dinamiku te imaju veliki potencijal za primjenu u biomedicinskim znanostima, informacijskim tehnologijama i znanostima o okolišu. U nastavku naših istraživanja supramolekulskih sustava pažnja u ovom projektu bit će usmjerena na dva glavna područja: 1) nanoproizvode, sintezu i karakterizacija novih mekih nanomaterijala temeljenih na organo- i hidro-gelovima s inkorporiranim oksalilamidnim ili fumaramidnim centralnim jedinicama i sinteze bioinspiriranih supramolekulskih sustava baziranih na samoorganizacijama  prirodnih peptida, priprava novih materijala polimerizacijom gelske mreže i razvoj novih supramolekulskih materijala koje uključuju fotoaktivne funkcionalne skupine 2) dizajn, priprema i karakterizacija novih funkcionalnih supramolekulskih sustava baziranih na liposomima i ß-ciklodekstrinama za ciljanu dostavu lijekova i istraživanje staničnog prepoznavanja. Nadalje, testirat će se biološki potencijal sintetiziranih funkcionalnih supramolekulskih sustava u dostavi lijekova i genskoj dostavi.]]></summary_hr><summary_en><![CDATA[Research in the framework of the proposed project is interdisciplinary with the aim of design, supramolecular synthesis and characterization of new functional supramolecular self-assembled nanostructures for construction of advanced functional materials. Molecular self-assembly usually takes advantage of supramolecular interactions (ionic, hydrophobic, van der Waals, hydrogen and coordination bonds) which allow construction of new nanostructures with attractive properties. Based on the rules of supramolecular chemistry, the bottom-up approach to design functional structures at the nanoscale is currently producing highly sophisticated materials for wide application. These structural features are nowadays well understood and can be finely controlled in order to introduce and tune specific functional properties of self-assembled nanomaterials. Further, such systems exhibit a complex array of morphologies and dynamics and have a huge potential for new applications in biomedical sciences, information technologies and environmental sciences. In continuation of our previous research of self-assembly systems the attention in this project will be focused on two main areas of research: 1) nanofabrication, preparation and characterization of new soft nanomaterials based on organo- and hydro-gels with incorporated oxalylamide or fumaramide central units and synthesis of bioinspirated supramolecular systems based on self-assembled natural peptides, the preparation of new materials by gel polymerization and the development of new supramolecular materials that incorporate photoactive functional groups 2) design, preparation and characterization of new functional supramolecular systems based on liposomes and ß-cyclodextrines for targeted drug delivery and surface recognition studies. Further, biological potential of synthesized functional supramolecular systems in drug and gene delivery will be tested. ]]></summary_en></project><project>
<id>7608</id><title_hr><![CDATA[Razvoj kapilarne mikroprobe za MeV SIMS s primjenom na analizu bioloških materijala]]></title_hr><title_en><![CDATA[]]></title_en><user_id>2755</user_id><user_firstLast_name>Ivančica Bogdanović Radović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-4454</code><acronim><![CDATA[BioCapSIMS]]></acronim><duration>09.10.2018 - 08.10.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>25285</team_members_id><team_members_names><![CDATA[ Doktorand: Marko Brajković ]]></team_members_names><keywords_hr><![CDATA[teški ioni, kapilarna mikroproba, MeV SIMS, biološki uzorci, ispodmikronska rezolucija]]></keywords_hr><keywords_en><![CDATA[heavy ions, capillary microbeam, MeV SIMS, biological samples, sub-micron resolution]]></keywords_en><summary_hr><![CDATA[Određivanje molekularnog sastava na staničnom nivou važno je za razumjevanje biokemijskih procesa unutar stanica a time i za istraživanje nastanka pojedinih bolesti. Jedna od obećavajućih masenih spektrometrija za 2D molekularno mapiranje na staničnom nivou je i MeV SIMS, spektrometrija sekundarnih molekularnih iona pomoću iona MeVskih energija koja je 2013. instalirana na ionskoj mikroprobi akceleratora u Zagrebu. Nedavno je pokazano da je s trenutnim eksperimentalnim postavom moguće postići 2D mapiranje molekula unutar stanice s lateralnom razlučljivošću ispod jednog mikrometra. Ipak, puni potencijal metode moglo bi se ostvariti samo korištenjem najtežih iona (npr I, Au) energija oko 30 MeV-a, što u postojećem MeV SIMS sustavu na ionskoj mikroprobi IRB-a nije moguće zbog ograničenja u potrebnim magnetskim poljima ionsko-optičkih elemenata. Naime od ranije je poznato da prinos sekundarnih molekularnih iona jako ovisi o elektronskoj zaustavnoj moći iona koji se koriste kao pobuda, te je znatno veći ako se koriste teški ioni visokih energija. Visoka vjerojatnost ovih procesa omogućila bi da se umjesto složenog sustava fokusirajućih leća ionski snop kolimira na mikronske dimenzije pomoću staklene kapilare. Nova kapilarna mikroproba za MeV SIMS koja bi u potpunosti bila optimizirana za 2D mapiranje bioloških materijala bi zbog svoje jednostavnosti mogla biti u daleko široj primjeni posebno na akceleratorima koji nemaju složene i skupe sustave za fokusiranje iona. Također, kapilarna mikroproba sa masenim spektrometrom bit će izgrađena na centralnoj eksperimentalnoj liniji 6.0 MV tandem akceleratora IRB-a te bi se tako minimizirale i teškoće zakretanja ionskog snopa u skretnom magnetu. Na taj način dobio bi se uređaj koji bi i po lateralnoj razlučljivosti i po prinosu sekundarnih molekularnih iona bio superioran u odnosu na postojeće slične uređaje za masenu spektrometriju bioloških materijala.]]></summary_hr><summary_en><![CDATA[Determination of the molecular composition at the cellular level is important to understand the biochemical processes within the cells and thus to explore the occurrence of certain diseases. One of the promising mass spectrometry methods for 2D molecular mapping at the cellular level is MeV SIMS, spectrometry of secondary molecular ions using MeV ions that was installed in 2013 at the ion microprobe in Zagreb. Recently we have demonstrated that with the current experimental setup we can achieve 2D imaging of molecular distribution within the cell with the sub-micron later resolution. However, the full potential of the method could only be achieved by using heavier ions such as I or Au with energies up to 30 MeV, which is presently not possible in the current MeV SIMS setup due to the limitations in the required magnetic fields in the ion-optical elements. It is already known that the secondary molecular ion yield strongly depends on the electronic stopping power of the used ions which increases significantly for heavier high energy ions. High probability of these processes allow us that instead of a complex system of focusing lenses ion beam can be collimated to micron dimensions by using glass capillaries. New capillary microprobe for MeV SIMS that would be fully optimised for 2D mapping of biological samples due to its simplicity could be very interesting at accelerators facilities that do not have complex and expensive systems for ion focusing. Also, capillary microprobe mass spectrometer will be mounted in the central experimental line of the 6.0 MV tandem accelerator RBI in order to minimise the difficulties of turning ion beam to the other beam lines. In this way the setup can be obtained with the lateral resolution and secondary ion molecular yields that is superior to the existing similar setups for mass spectrometry of biological materials.]]></summary_en></project><project>
<id>7609</id><title_hr><![CDATA[Sto dvadeset i pet  milijuna piksela za otkriće vezanja Higgsovog bozona na fermione i novih čestica na Velikom hadronskom sudarivaču]]></title_hr><title_en><![CDATA[]]></title_en><user_id>19738</user_id><user_firstLast_name>Dinko Ferenček</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-9182</code><acronim><![CDATA[HIGGS125]]></acronim><duration>14.06.2019 - 31.03.2023</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>29408</team_members_id><team_members_names><![CDATA[ Doktorand: Saswat Mishra ]]></team_members_names><keywords_hr><![CDATA[Higgsov bozon, fermionska vezanja, Standardni model, nove čestice, identifikacija b kvarkova, piksel detektor, LHC]]></keywords_hr><keywords_en><![CDATA[Higgs boson, fermionic couplings, Standard model, new particles,  b tagging, pixel detector, LHC]]></keywords_en><summary_hr><![CDATA[Ulaskom u drugu fazu rada Velikog hadronskog sudarivača čestica (LHC) na CERN-u započelo je još jedno uzbudljivo razdoblje u istraživanju temeljnih gradivnih  elemenata tvari. Opažanjem čestice sa svojstvima Higgsovog bozona na LHC-u čini se da je potvrđeno jedno od središnjih predviđanja Standardnog modela (SM) fizike čestica.  Međutim, sva svojstva otkrivene čestice tek se trebaju precizno odrediti kako bi se potvrdilo da je ona uistinu Higgsov bozon predviđen Standardnim modelom.  Cilj projekta je proučavanje vezanja Higgsovog bozona s fermionima, koja su u SM-u odgovorna za mase kvarkova i leptona. Ova vezanja dopuštaju raspade  Higgsovog bozona u fermione.  Međutim, takvi raspadi još nisu opaženi. Cilj projekta je opažanje raspada Higgsovog bozona u par b kvarkova  te precizno mjerenje učestalosti ovog raspada koristeći sve podatke koji će se prikupiti detektorom CMS u drugoj fazi rada LHC-a. Neopažanje ovog raspada ili odstupanje učestalosti raspada od vrijednosti predviđenih SM-om ukazalo bi na postojanje fizike izvan SM-a što bi bilo od iznimne važnosti. Cilj projekta su i izravne potrage za novim česticama proučavanjem konačnih stanja s b kvarkovima.  Projekt također namjerava pridonijeti poboljšanju performansi detektora CMS boljom identifikacijom hadronskih mlazova koji nastaju hadronizacijom b kvarkova (b mlazovi). Unapređenju identifikacije b mlazova (B označavanje) ponajviše će doprinijeti instalacija nadograđenog silicijskog piksel detektora početkom 2017. Jedan od ciljeva projekta je optimizacija performansi identifikacije b mlazova koristeći svojstva nadograđenog detektora, s posebnim naglaskom na označavanje topologija u kojima su se dva vrlo energijska b mlaza spojila u jedan mlaz. To će ovisiti o dobroj integraciji nadograđenog piksel detektora u CMS mjerenja, te projekt također uključuje niz ciljeva vezanih uz poboljšanje performansi piksel detektora i rekonstrukcije događaja.]]></summary_hr><summary_en><![CDATA[With the start of the second running phase (Run 2) of the Large Hadron Collider (LHC) at CERN, the study of the fundamental constituents of matter has again entered an exciting time. The observation of a Higgs-like boson at the LHC seems to confirm a central prediction of the Standard Model (SM) of particle physics. All properties of the discovered particle need however to be accurately determined to establish whether the new particle is the Higgs boson predicted in the SM.The proposal aims at studying the couplings of the Higgs boson to fermions, which in the SM gives rise to masses of quarks and leptons. These couplings allow the Higgs boson to decay into fermions. No such decay has however been observed yet. This projects targets an observation of the Higgs boson decay into a pair of b quarks, and a precise measurement of this decay rate using the full dataset to be acquired by the CMS detector during Run 2. A lack of observation of this decay or a deviation of its rate from the SM expectation would point at the presence of physics beyond the SM and be of great significance. The project also aims at direct searches for new particles by studying final states with b quarks.The project also intends to contribute to the improved performance of the CMS detector by improving the identification of hadronic jets stemming from the hadronization of a b quark (b-jets). The identification of b-jets (B tagging) will in particular benefit from the installation of an upgraded silicon pixel detector in early 2017. One of the project goals consists in optimizing the B tagging performance using the features of the upgraded detector, with a special focus on the tagging of topologies in which two very energetic b-jets are merged in one so-called “fat jet”. This relies on a good integration of the upgraded pixel detector in the CMS measurements, and the project therefore also includes a set of objectives linked to the improvement of the pixel detector performance and reconstruction.]]></summary_en></project><project>
<id>7610</id><title_hr><![CDATA[Interakcije slatkovodnih patogenih oomiceta i okoliša]]></title_hr><title_en><![CDATA[]]></title_en><user_id>18946</user_id><user_firstLast_name>Ana Bielen</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-8751</code><acronim><![CDATA[InteractOomyc]]></acronim><duration>01.10.2018 - 30.09.2022</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Biotehnologija, </scie_field_hr><scie_field_en>Biotechnology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Food Technology and Biotechnology]]></institution_en><team_members_id>25270</team_members_id><team_members_names><![CDATA[ Doktorand: Anđela Miljanović ]]></team_members_names><keywords_hr><![CDATA[patogeni oomiceti, slatkovodni rakovi, slatkovodna akvakultura, mikrobne zajednice, ekološke interakcije]]></keywords_hr><keywords_en><![CDATA[pathogenic oomycetes, freshwater crayfish, freshwater aquaculture, microbial communities, ecological interactions]]></keywords_en><summary_hr><![CDATA[U posljednja dva desetljeća globalno širenje oomicetnih patogena u slatkovodnim ekosustavima uzrokuje smanjenje brojnosti mnogih populacija. Istovremeno, oomicetni patogeni uzrokuju značajne ekonomske gubitke u slatkovodnoj akvakulturi. Unatoč tome, većina postojećih istraživanja fokusirana je na odnos domaćina i uzročnika bolesti, dok se drugi tipovi ekoloških interakcija u koje su uključeni slatkovodni oomiceti uglavnom ne uzimaju u obzir. Stoga je osnovni cilj predloženog projekta poboljšati razumijevanje ekologije oomicetnih patogena u slatkovodnim ekosustavima. Kao modelni organizmi koristiti će se dva patogena oomiceta - Aphanomyces astaci i Saprolegnia sp. A. astaci je kao uzročnik račje kuge odgovoran za nestanak brojnih populacija zavičajnih deseteronožnih rakova u Europi i time je goruća tema u području konzervacije rakova. Oomiceti iz roda Saprolegnia uzročnici su saprolegnioze - bolesti pastrve i drugih salmonidnih riba značajnih za slatkovodnu akvakulturu u Hrvatskoj i svijetu. Primjenom interdisciplinarnog pristupa u kojem će se preklopiti moderne kemijske, molekularno-biološke, mikrobiološke i bioinformatičke metode, projekt će odgovoriti na nekoliko međunarodno relevantnih i do sada neistraženih pitanja. Istražit će se utjecaj abiotskih (sastav vode) i biotskih (sastav mikrobnih zajednica) čimbenika na različite faze životnog ciklusa oomiceta. Na taj će se način predvidjeti &#39;&#39;vruće točke&#39;&#39; koje imaju povećani rizik od širenja/izbijanja bolesti uzrokovanih oomicetima u slatkovodnim ekosustavima. Osim toga, istražiti će se potencijal komenzalnih bakterijskih zajednica domaćina za inhibiciju rasta oomiceta, kao i odabranih biljnih ekstrakata koji bi se mogli primijeniti kao mjera kontrole saprolegnioze u akvakulturi. Zaključno, rezultati predloženog projekta donijet će nova fundamentalna znanja o interakcijama oomicetnih patogena i njihovog okoliša te istražiti nove metode njihove kontrole.]]></summary_hr><summary_en><![CDATA[In the last two decades, global spreading of oomycete pathogens in freshwater ecosystems is causing decline of many populations. At the same time, oomycete pathogens are also causing significant economic losses in freshwater aquaculture. Despite of this, most of the existing research is focused on host/pathogen relationship, whereas other types of ecological interactions are largely overlooked. Therefore, the main objective of the proposed project is to improve understanding of the oomycete pathogens ecology in freshwater ecosystems. Two model oomycete pathogens will be used - Aphanomyces astaci and Saprolegnia sp. A. astaci is the causative agent of crayfish plague and is responsible for the disappearance of numerous indigenous decapod crayfish populations in Europe, which makes it a hot topic in the area of crayfish conservation. Oomycetes in the genus Saprolegnia are causing saprolegniosis – a disease of trouts and other salmonid fish important for freshwater aquaculture in Croatia and globally. Using an interdisciplinary approach with complementing methods in chemistry, molecular biology, microbiology and bioinformatics, the project will try to answer on several so far unexplored and internationaly relevant issues. The effect of abiotic (water composition) and biotic (microbial communities composition) factors on different oomycetal life cycle stages will be investigated. In that manner „hot spots“ in freshwater ecosystem will be predicted, having increased risk for outbreak/spreading of diseases caused by oomycete pathogens. In addition, the potential of hosts comensal bacterial communities and selected plant extracts to inhibit the growth of oomycetes will be investigated, as well as their potential application in controlling saprolegniosis in aquaculture. In summary, results of the proposed project will bring about new basic knowledge about oomycete pathogens interaction with their environment, and asses new methods for their control. ]]></summary_en></project><project>
<id>7612</id><title_hr><![CDATA[Međuusporedba metoda mjerenja denudacije krša]]></title_hr><title_en><![CDATA[Inter-comparison of karst denudation measurement methods]]></title_en><user_id>6006</user_id><user_firstLast_name>Kristina Krklec</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-7080</code><acronim><![CDATA[KADEME]]></acronim><duration>01.10.2018 - 30.09.2022</duration><status>Završio</status><financ_value>132.632,56 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Agronomski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Agriculture]]></institution_en><team_members_id>4675, 19493, 20456, 24181, 24134, 24096, 24218, 25734, 855332, 865056, </team_members_id><team_members_names><![CDATA[Sonja Lojen, David Domínguez-Villar, Aleksandra Bensa, Braucher Regis, Sanja Lozić, Dražen Perica, Natalija Andačić, Kristina Koret, Mirna Švob, Josip Šušnjar, ]]></team_members_names><keywords_hr><![CDATA[denudacija, trošenje stijena, tlo, krš, špilja]]></keywords_hr><keywords_en><![CDATA[denudation, rock weathering, soil, karst, cave]]></keywords_en><summary_hr><![CDATA[Denudacija površine temeljni je proces razvoja reljefa i tla. Otapanjem karbonata ostaje netopivi ostatak iz kojeg se može razviti tlo. Stoga je poznavanje brzine trošenja stijena i denudacije važno za evaluaciju potrebnog vremena za razvoj tla. Postoji nekoliko različitih metodoloških pristupa za mjerenje stope denudacije. Najčešće se koriste: izlaganje stijenskih pločica uvjetima u okolišu; upotreba mikro-erozijskog metra; mjerenje koncentracije kozmogenih radionuklida na izloženim stijenama i mjerenje hidrokemijskih značajki vode u svrhu određivanja količine otopljenih karbonatnih stijena. Svaka metoda ima prednosti i nedostatke i ne postoji konsenzus o tome koja metoda pruža najpouzdanije vrijednosti stope denudacije, štoviše, zabilježene su značajne razlike u rezultatima među metodama. Stoga ovo istraživanje ima za cilj identificirati metode koje bi mogle pružiti pristrane rezultate i ukazati na prednosti i nedostatke svake metode, kako bi se istraživačima olakšao odabir bolje metode ovisno o ciljevima njihovih istraživanja.Metode će se primijeniti na dvije različite lokacije pod utjecajem mediteranske klime, ali s vrlo različitom debljinom tla. Ovaj pristup važan je za vrednovanje sprege stope denudacije i debljine tla, te za utvrđivanje jesu li rezultati usporedbe metoda sustavni na mjestima s promjenjivom značajkama. Dobivene stope denudacije koristiti će se za procjenu produkcije materijala na lokacijama istraživanja, odnosno za proučavanje potencijalne proizvodnje tla ovisno o denudaciji. Važnost ovoga ogleda se u činjenici da je u scenariju erozije tla u mediteranskoj regiji važno znati potencijal oporavka tih sustava.]]></summary_hr><summary_en><![CDATA[Denudation of earth surface is the fundamental process governing the landscape and soil development. The dissolution of carbonates results in insoluble material of these rocks being available for the development of soils. Therefore, knowing rock denudation-weathering rates is important to evaluate the time required for a certain soil to develop. There are several different methodological approaches to measure denudation rate. The must commonly used are: the exposure of rock tablets to the natural environment; the use of micro-erosion meters; measuring the concentration of cosmogenic radionuclides on exposed rocks and measuring water hydrochemistry to infer amount of carbonates being dissolved. Every method has pros and cons and there is no consensus on which method provides the more reliable denudation rates, furthermore, significant differences among methods have been reported. Therefore, this investigation aims to identify methods that could provide biased results and as well to report the strengths and flaws of every method, to help researchers to select the better methods depending on the goals of their particular studies.The methods will be applied at two different locations affected by Mediterranean climate, but with very different soil thickness. This approach is important to evaluate the feedback of soil thickness on denudation rates, and confirm if the conclusions from the method comparison are systematic on sites with variable characteristics. The denudation rates obtained will be used to evaluate the production of material at the studied sites to study the potential production of soil depending on denudation. This is important, since in a scenario of soil erosion in the Mediterranean region, it is important to know the potential recovery of these systems. ]]></summary_en></project><project>
<id>7613</id><title_hr><![CDATA[Utjecaj prehrambenih vlakana na bioraspoloživost polifenola istraživanjem adsorpcije i simuliranih probavnih procesa, in vitro]]></title_hr><title_en><![CDATA[]]></title_en><user_id>7376</user_id><user_firstLast_name>Lidija Jakobek Barron</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-6710</code><acronim><![CDATA[BIO-POLIFENOL]]></acronim><duration>01.10.2018 - 30.09.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Prehrambena tehnologija, </scie_field_hr><scie_field_en>Food technology, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Prehrambeno-tehnološki fakultet]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Food Technology]]></institution_en><team_members_id>25258</team_members_id><team_members_names><![CDATA[ Doktorand: Jozo Ištuk ]]></team_members_names><keywords_hr><![CDATA[adsorpcija, bioraspoloživost, b-glukan, prehrambena vlakna, polifenoli, bioaktivnosti]]></keywords_hr><keywords_en><![CDATA[adsorption, bioaccessibility, b-glucan, dietary fiber, polyphenols, bioactivities]]></keywords_en><summary_hr><![CDATA[Ranijim istraživanjima pokazalo se da polifenolni spojevi imaju razne bioaktivnosti. Od antioksidacijskog djelovanja do modulacije enzima, djelovanja metabolita polifenola, interakcija s mikroflorom te interakcija s makromolekulama prisutnima u hrani. Sve ove bioaktivnosti mogu zajedno objasniti potencijalno pozitivan utjecaj polifenola na zdravlje. U zadnje vrijeme pažnja se posvećuje interakcijama s makromolekulama u hrani jer one mogu utjecati na bioraspoloživost polifenola. Bioraspoloživost se definira kao količina nutrijenata koji su raspoloživi za apsorpciju u probavnom traktu. Ukoliko polifenoli kroz interakcije s molekulama iz hrane bivaju “zarobljeni” (vezani) za molekule to može utjecati na raspoloživost za njihovu apsorpciju te na njihovo djelovanje u organizmu. Prehrambena vlakna imaju potencijal  vezanja polifenola te ih na taj način mogu zaštititi od razgradnje i prenijeti u donje dijelove probavnog trakta. To može utjecati na bioraspoloživost, ali imati i druge potencijalno pozitivne efekte – polifenoli mogu u izvornom obliku pokazati pozitivne bioaktivnosti u donjim dijelovima probavnog trakta. U ovom projektu cilj je istražiti bioraspoloživost polifenola kroz dva procesa. Prvi bi bio istraživanje procesa adsorpcije polifenola na prehrambenim vlaknima (b-glukan). U ovom dijelu istraživala bi se adsorpcija polifenolnih standarda na prehrambena vlakna (b-glukan) te utjecaj pH, temperature i vremena na adsorpciju. Preko adsorpcije bi se interpretirale interakcije koje se mogu dogoditi između polifenola i prehrambenih vlakana. Drugi proces koji bi se istraživao bio bi simulirani probavni proces, in vitro, u kojem bi se simulirali probavni procesi te istraživala količina polifenola (iz voća) u izvornom obliku nakon probave te utjecaj prehrambenih vlakana na ovaj proces. Rezultatima iz istraživanja adsorpcije i simuliranih probavnih procesa interpretirala bi se bioraspoloživost polifenola te utjecaj prehrambenih vlakana na bioraspoloživost.]]></summary_hr><summary_en><![CDATA[Previous studies have shown that the polyphenolic compounds have various bioactivities: from antioxidant activity to the modulation of enzymes, the action of polyphenol metabolites, interaction with the microflora, and interactions with macromolecules present in food. All of these bioactivities can together explain a potentially positive effect of polyphenols on health. Lately, attention is paid to interactions with macromolecules in food because they can affect the bioaccessibility of polyphenols. Bioaccessibility is defined as the amount of nutrients available for absorption in the gastrointestinal tract. If polyphenols through interaction with molecules from food are &#39;&#39;captured&#39;&#39; (linked) to molecules that can affect the availability for their absorption and their effects in the body. Dietary fibers have the potential to bind polyphenols. Polyphenols can thus be protected from degradation and transferred to the lower parts of intestinal tract. This may affect the bioaccessibility, or have other potentially positive effects - polyphenols may in their original form show positive bioactivities in the lower digestive tract. In this project, the goal is to explore the bioaccessibility of polyphenols through two processes. The first will be the study the adsorption of polyphenols onto dietary fiber (b-glucan), along with the impact of pH, temperature and time on this process. Through adsorption, the interactions that can occur between polyphenols and dietary fiber could be interpreted. Another process that will be studied is the simulated digestion process, in vitro, which would simulate the digestive processes, explore the amount of polyphenols (in fruit) in its original form upon digestion, and the effect of dietary fiber on this process. The results from the adsorption and simulated digestive processes would be used to interpret bioaccessibility of polyphenols and the impact of dietary fiber on bioaccessibility.]]></summary_en></project><project>
<id>7614</id><title_hr><![CDATA[MATH-BTB proteini kao regulatori transkripcije i RNA posredovane metilacije DNA u biljnom razvitku]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3746</user_id><user_firstLast_name>Dunja Leljak-Levanić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-2144</code><acronim><![CDATA[PHYTOMETHDEV]]></acronim><duration>10.10.2018 - 31.12.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>25338</team_members_id><team_members_names><![CDATA[ Doktorand: Tamara Vuk ]]></team_members_names><keywords_hr><![CDATA[metilacija DNA, RdDM, MATH-BTB, embriogeneza, stres, biljke]]></keywords_hr><keywords_en><![CDATA[DNA methylation, RdDM, MATH-BTB, embryogenesis, stress, plants]]></keywords_en><summary_hr><![CDATA[Metilacija DNA jedan je od nekoliko epigenetičkih mehanizama kontrole ekspresije gena. U biljaka raznolikost epigenetičkih mehanizama ima, osim u regulaciji razvojnih procesa, važnu ulogu u fenotipskoj i fiziološkoj prilagodljivosti, te sposobnosti biljaka da prežive i razmnožavaju se u promjenjivom okolišu. Metilacija biljne DNA odvija se na sljedovima CG, CHG i asimetričnom CHH (H simbol za A, C ili T), a svaki od njih ima različite &#39;&#39;genetičke zahtjeve&#39;&#39; za očuvanje. Nesimetrična metilacija CHH ne može se održati i zahtijeva de novo metilaciju u svakom staničnom ciklusu. Proces kojim se to ostvaruje je metilacija DNA usmjerena s RNA (RdDM). Dvije RNA polimeraze specifične za biljke, Pol IV i Pol V sintetiziraju male interferirajuće RNA, odnosno dugačke nekodirajuće molekule RNA, važne za RNA-DNA prepoznavanje. Kompleks DDR predstavlja proteinski kompleks za koji se smatra da je odgovoran za dovođenje enzima Pol V na mjesto regulacije gena, no mehanizam specifičnosti nije jasan. Naši preliminarni rezultati ukazuju da proteini MATH-BTB iz uročnjaka stupaju u interakciju s kompleksom DDR, te tako mogu posredovati u pozicioniranju sustava RdDM. Najnovija otkrića ukazuju da su supstrati proteina BPM transkripcijski faktori. Proteini s ovakvim interakcijskim mogućnostima imaju potencijal  održavanja ravnoteže između metilacije (posredovane Pol V) i transkripcije (posredovane Pol II). Glavni cilj projekta je rasvjetljavanje funkcionalne uloge proteina BPM u regulaciji transkripcije i RdDM-a kao i moguće uloge u biljnoj embriogenezi i prilagodbi na stresne uvjete. Posebna pozornost biti će dana identifikaciji gena čija je transkripcija ili RdDM metilacija uravnotežena proteinom BPM1 (kromatinska imunoprecipitacija-ChIP, ChIP-sekvenciranje). Nadalje, metilacijski uzorak (bisulfitno sekvenciranje) odabranih gena će biti povezan s njihovom ekspresijom (Q-PCR), te s embriogenezom i odgovorom biljaka na stres u linijama s promijenjenim sustavom RdDM ili ekspresijom gena BPM.]]></summary_hr><summary_en><![CDATA[DNA methylation is one of several epigenetic mechanisms used by cells to control gene expression. In plants epigenetic diversity, besides regulating development, presumably contributes in plant phenotypic and physiological plasticity and the ability to survive and reproduce in unpredictable environments. Plant DNA methylation occurs at CG, CHG and nonsymmetrical CHH (where H is A, C or T) sequences, each of which has different genetic requirements for its preservation. Nonsymmetrical CHH methylation cannot be sustained by the maintenance machinery and require de novo methylation in each cell cycle through a process called RNA-directed DNA methylation (RdDM). Two plant specific RNA polymerases, Pol IV and Pol V, produce small interfering RNAs and long non-coding RNAs respectively, which are important for RNA-DNA target sequence recognition. The DDR complex represents a major determinant that is proposed to be responsible for recruitment of the Pol V enzyme to the specific loci, but the mechanism is still not clear. Our preliminary results indicate that Arabidopsis MATH-BTB proteins recognize and interact with the DDR complex and thus might mediate the positioning of RdDM machinery. Recent findings indicate that substrates of BPM proteins are predominantly transcription factors. These two properties of a single BPM protein suggest its capacity to act as a control switch between methylation (mediated by Pol V) and transcription (mediated by Pol II). The main goal of this project is to elucidate the functional roles of BPMs in orchestrating transcription and RdDM, and its possible role in plant embryogenesis and stress adaptation. Particular focus will be placed to identification of genes whose transcription or RdDM methylation is affected by BPMs (by ChIP and ChIP seq). Further, methylation context (bisulfite sequencing) of selected genes will be correlated with their expression (Q-PCR) and with embryogeneis and stress responses in different RdDM and BPM mutant lines.]]></summary_en></project><project>
<id>7615</id><title_hr><![CDATA[Demistificiranje dvočestičnih korelacija u pp sudarima s nadograđenom komorom vremenske projekcije]]></title_hr><title_en><![CDATA[Demystifying Two Particle Correlations in pp collisions with the upgraded Time Projection Chamber]]></title_en><user_id>7691</user_id><user_firstLast_name>Mirko Planinić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-4108</code><acronim><![CDATA[TPCwithTPC]]></acronim><duration>01.10.2018 - 31.10.2022</duration><status>Završio</status><financ_value>132.515,36 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>12808, 13010, 24010, 13058, 28908, </team_members_id><team_members_names><![CDATA[Nikola Poljak, Filip Erhardt, Marko Jerčić, Antonija Utrobičić, David Karatović , ]]></team_members_names><keywords_hr><![CDATA[Dvočestične korelacije, Kvarkovsko-gluonska plazma, TPC, GEM, Iskrenje, RIDGE]]></keywords_hr><keywords_en><![CDATA[Two particle correlations, Quark-Gluon Plasma (QGP), TPC, GEM, sparking, RIDGE]]></keywords_en><summary_hr><![CDATA[Primarni cilj ovog projekta je istražiti dvočestične korelacije čestica u sudarima protona (pp) koristeći varijable oblika događaja koje je naša grupa u prethodnim analizama opsežno koristila. 2010. g. izmjerena je izražena struktura u dvodimenzionalnoj funkciji angularnih korelacija za parove čestica kod malih azimutalnih kutnih razlika delta phi i preko širokog raspona razlika pseudorapiditeta delta eta. Ta je struktura nazvana &#39;&#39;greben&#39;&#39;, a promatrana je u događajima s velikim multiplicitetom. Korelacija grebena prvi put se vidjela u sudarima teških iona u kojima znamo da se proizvodi kvarkovsko-gluonska plazma (QGP). Nedavno je opažena struktura grebena u pp događajima visokog multipliciteta kod 7 TeV. Greben u  pp događajima visokog multipliciteta potaknuo je spekulacije o formiranju QGP u malim sustavima. Nedavni rezultati ALICE-a o prvom opažanju povećanja stranosti u sudarima protona s velikim multiplicitetom također nam govore da još ne razumijemo mehanizam formiranja QGP. Korištenje metoda razvijenih u PI grupi može pomoći u razumjevanju podrijetla strukture &#39;&#39;grebena&#39;&#39; novom metodom eliminiranja pozadine koju je već uspješno koristila naša grupa.  Sekundarni cilj ovog projekta je demistificirati pojavu iskrenja  GEM detektora  koji se koriste za TPC nadogradnju ALICE detektora na CERN-u. PI je utemeljio GEM laboratorij s čistom sobom koristeći prijašnji  UKF projekt i grupa je već stekla značajno iskustvo s GEM folijama. GEM folije su sastavni dio nadolazeće nadogradnje ALICE detektora, budući da su neophodne za planirane  pp i teškoionske sudare velikog luminoziteta. Ova nadogradnja je također motivirana otvorenim pitanjima u QGP-u, budući da će run velikog luminoziteta rezultirati značajnim povećanjem količine podataka koji se koriste za QGP analize.]]></summary_hr><summary_en><![CDATA[The primary objective of this project is to explore two particle correlations in proton-proton (pp) collisions using event shape variables extensively used by our group in previous analyses. In 2010, a pronounced structure in the two-dimensional angular correlation function was measured for particle pairs at small azimuthal angle differences delta phi and over a wide range of pseudorapidity differences delta eta. This structure was named the “ridge” and is observed in events with sufficiently high multiplicity. The ridge correlation was first seen in those heavy ion collisions for which we firmly believe that quark-gluon plasma (QGP) is produced.Recently, the ridge correlation was also observed in high-multiplicity pp events at 7 TeV. The appearance of this “ridge-like” structure in high-multiplicity pp events caused speculation for the formation of QGP in small systems. Recent ALICE results of the first observation of strangeness enhancement in high-multiplicity pp collisions are also telling us that we do not yet understand the mechanism of QGP formation. Using the methods developed in the PI’s group may help understand the origin of “ridge-like” structures by a novel background elimination method which was already successfully used by our group. The secondary objective of this project is to demystify the occurrence of sparking in Gas Electron Multiplier (GEM) detectors that are used for TPC upgrade of the ALICE detector at CERN. The PI has founded a GEM Lab with a clean room using a previous Unity through Knowledge Fund grant and the group has already gained significant experience with GEM foils. The GEM foils are an integral part of the upcoming ALICE detector upgrade, since they are essential for the planned high luminosity pp and heavy ion collisions at the LHC. This upgrade is also motivated by the open questions in QGP, since a high luminosity run will result in a significant increase in the data sample used for QGP analyses. ]]></summary_en></project><project>
<id>7618</id><title_hr><![CDATA[Željeznodobni ženski identiteti u južnom dijelu Karpatske kotline]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3432</user_id><user_firstLast_name>Hrvoje Potrebica</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-7084</code><acronim><![CDATA[FEMINE]]></acronim><duration>01.10.2018 - 29.06.2024</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Arheologija, </scie_field_hr><scie_field_en>Archeology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>25275</team_members_id><team_members_names><![CDATA[ Doktorand: Julia Katarina Kramberger ]]></team_members_names><keywords_hr><![CDATA[željezno doba, žene, identitet, Karpatska kotlina, nošnja, nakit, grobovi, groblja, rod, funkcionalna analiza, bioarheologija]]></keywords_hr><keywords_en><![CDATA[Iron Age, females, identity, Carpathian Basin, costume, jewellery, graves, cemeteries, gender, functional analysis, bioarchaeology]]></keywords_en><summary_hr><![CDATA[Cilj predloženoga projekta o razdoblju željeznoga doba, poduzetoga od strane arheologije u suradnji s antropološkim i arheometalurškim istraživanjima, naglasak stavlja na proučavanje različitih aspekata željeznodobnih (ŽD) ženskih društvenih identiteta koji se jedino mogu rekonstruirati iz arheoloških podataka. U projektu je predviđeno istraživanje zajedničkih modela, uz korištenje trenutnih interdisciplinarnih mogućnosti, koji se odnose na proučavanje rodnoga koncepta, što će predstavljati inovativnu aktivnost i značajan napredak u istraživanju ŽD zajednica u južnom dijelu Karpatske kotline (KK). Ženski identitet sastavljen je od višestrukih značajki koje su združene kako bi stvorile individualnu osobnost. Za vrijeme života pojedinac ima različite društvene identitete, čak i po nekoliko u isto vrijeme. Žene za vrijeme ŽD u južnom dijelu KK postaju posebno vidljive na osnovi arheoloških nalaza koji pokazuju razvoj brojnih karakterističnih predmeta. Naše trenutne spoznaje o položaju i ulozi žena većinom potječu iz istraživanja groblja koja nude prilično točnu sliku o svakodnevnom životu ŽD zajednica. Za vrijeme ŽD u KK uobičajeno je kako su pokojnice bile pokopane u svakodnevnoj nošnji i s osobnim nakitom koji se, s nalazima pršljena, smatraju kao iznimno jasan rodni prikaz. Projekt predstavlja kompleksnu studiju poznatih ŽD ženskih pokopa sa šest groblja u promatranom području na osnovi roda, dobi i grobnih priloga koje mogu obogatiti naše spoznaje o ŽD društvu na mnogo načina, pri čemu se posebna pažnja posvećuje funkcionalnoj analizi kombinacija u grobovima koje prikazuju različite lokalne ŽD zajednice te  višestruke identiteta jedne osobe. Funkcionalna analiza, odnosno kako su različiti elementi nošnje i nakita organizirani i udruženi u različite kombinacije, pruža pouzdane podatke o načinima koje su različiti pojedinci i/ili zajednice odabirali kako bi vizualno prikazali vlastite identitete i društvene odnose.]]></summary_hr><summary_en><![CDATA[Aim of proposed Iron Age project, conducted by archaeology in collaboration with anthropological and archaeometallurgical researches, is emphasis placed on the study of different aspects of the Iron Age (IA) female social identities which only can be reconstructed from the archaeological records. In this project is planning to explore common models, with the use of current interdisciplinary possibilities, in the field of gender concept which will be innovative activity and significant improvements in exploring of IA communities in the southern Carpathian Basin (CB). Female identity is composed of multiple features that are connected together to create an individual personhood. During a lifetime an individual has various social identities, even several at the same time. Females during the IA in the southern CB become increasingly visible in the archaeological record through the development of numerous characteristic accessories. Our present knowledge about position and role of women comes mostly from cemeteries which offer a fairly accurate picture of the everyday life of the IA communities. During the IA in the CB was a standard for the deceased to be buried in the everyday costume and with personal jewellery which, with spindle whorls, are remarkably sharp gender outfits. A project represent a complex study of the known IA female burials from six cemeteries in define region in terms of gender, age and grave goods which can enrich our knowledge of the IA society in many ways, with special attention to the functional analysis of the grave assemblages which reflects different local IA communities and shared identities of single persons. Functional analysis, the manner in which different costume and jewellery elements are composed and associated in various assemblages, provides relevant information regarding the ways in which various individuals and/or different communities chose to visually express their identities and social relationships.]]></summary_en></project><project>
<id>7622</id><title_hr><![CDATA[METALOSUPRAMOLEKULSKE STRUKTURE I ANORGANSKO-ORGANSKI POLIOKSOMETALATNI HIBRIDI ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>134</user_id><user_firstLast_name>Višnja Vrdoljak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-2201</code><acronim><![CDATA[MOLART]]></acronim><duration>10.10.2018 - 31.12.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>25322</team_members_id><team_members_names><![CDATA[ Doktorand: Mirna Mandarić ]]></team_members_names><keywords_hr><![CDATA[metalosupramolekulski spojevi, polioksometalati, hibridi, hidrazoni, dikarboksilati, struktura, biološka svojstva, kvantno kemijski računi]]></keywords_hr><keywords_en><![CDATA[metallosupramolecular compounds, poyoxometalates, hybrides, hydrazones, dicarboxylate, structure, biological properties, quantum chemical calculations]]></keywords_en><summary_hr><![CDATA[Glavna ideja projekta temelji se na principima koordinacijske kemije u dizajnu i sintezi novih MoVI metalosupramolekulskih struktura i organsko-anorganskih hibridnih polioksometalatnih materijala. Sinteza novih spojeva bazirat će se na “bottom-up” pristupu, odnosno njihovoj pripravi iz građevnih blokova nastalih in situ kako u otopini tako i u čvrstom stanju. To će omogućiti ispitivanje procesa samoudruživanja i kristalnog rasta navedenih sustava. Poveznica svih segmenata istraživanja je i u pronalaženju uvjeta neophodnih u kontroli sastava, strukture i svojstava ciljnih spojeva. Očekuje se da će ovo istraživanje dati uvid u mehanizme ispitivanih reakcija i omogućiti tumačenje utjecaja različitih inter- i intramolekulskih interakcija na svojstva višedimenzionalnih sustava ili njihovih građevnih blokova. Metode koje će se koristiti u sintezi organskih, metalosupramolekulskih i anorgansko-organskih polioksometalatnih hibrida bit će modificirane metode otopinske kemije, ali će se koristiti i metodologije zelene kemije. Istraživanja termički induciranih reakcija u čvrstom stanju predstavljaju dodatni izazov ovoga projekta. Predloženi projekt sastoji se od sljedećih dijelova: (i) dizajna i sinteze multifunkcionalnih N,O-donorskih liganada i ispitivanja njihovih svojstava; (ii) sinteze novih MoVI metalosupramolekulskih sustava; (iii) sinteze novih hibridnih organsko-anorganskih polioksometalatnih spojeva; (iv) karakterizacije svih priređenih spojeva; (v) kvantno-kemijskih proračuna i teorijskih tumačenja eksperimentalnih rezultata s ciljem boljeg razumijevanja i poboljšanja ispitivanih procesa; (vi) ispitivanja kemijskih i fizikalnih svojstava priređenih spojeva; (vii) ispitivanja bioloških svojstava odabranih spojeva.]]></summary_hr><summary_en><![CDATA[The main idea of the project is to apply principles of coordination chemistry to design and synthesise new MoVI metallosupramolecular architectures and POM-based organic-inorganic hybrid materials. Such systems will be developed via a bottom-up approach combining suitable building blocks generated in situ in solution as well as in the solid state. The complexity in their construction is an invaluable opportunity to study the self-assembly and crystal growth processes. Links between all segments of this research are in finding suitable conditions that are necessary to control the composition and/or structural features of target architectures. It is expected that our investigation will give insight into particular reaction mechanisms and provide explanation for the influence of different inter- and intramolecular interactions on properties of high-dimensional compounds or their building blocks. Methods used in the synthesis of organic, metallosupramolecular and inorganic-organic hybrids will be modified and performed in accordance to conventional, but also green, chemical methodologies. Investigations of thermally induced reactions in the solid state are additional challenging part of the project. The proposed project consists of the following parts: (i) design and synthesis of multifunctional N,O-donor ligands and study of their properties; (ii) synthesis of novel MoVI metallosupramolecular architectures; (iii) preparation of novel hybrid organic-inorganic compounds based on polyoxomolybdates; (iv) characterisation of all prepared compounds; (v) quantum chemical calculations and theoretical support to the experimental research which will be used to understand and guide the improved efficiency of the studied processes; (vi) investigation of chemical and physical properties of prepared compounds; (vii) investigation of biological properties of selected compounds.]]></summary_en></project><project>
<id>7625</id><title_hr><![CDATA[H2020 “Mediterranean Aquaculture Integrated Development – MedAID”]]></title_hr><title_en><![CDATA[]]></title_en><user_id>2574</user_id><user_firstLast_name>Snježana Zrnčić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-2908</code><acronim><![CDATA[]]></acronim><duration>28.09.2018 - 31.12.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Veterinarska medicina, </scie_field_hr><scie_field_en>Veterinary medicine, </scie_field_en><institution_hr><![CDATA[Hrvatski veterinarski institut]]></institution_hr><institution_en><![CDATA[Croatian Veterinary Institute]]></institution_en><team_members_id>25383</team_members_id><team_members_names><![CDATA[ Doktorand: Ivana Giovanna Zupičić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>7628</id><title_hr><![CDATA[Normativni modeli vaskularnih biomarkera za unapređenje stratifikacije kardiovaskularnog rizika u primarnoj i sekundarnoj prevenciji]]></title_hr><title_en><![CDATA[Normative models of,vascular biomarkers for improvement of stratification of cardiovascular risk in primary and secondary prevention]]></title_en><user_id>2713</user_id><user_firstLast_name>Ana Jerončić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-4729</code><acronim><![CDATA[NormPreven]]></acronim><duration>12.11.2018 - 11.02.2024</duration><status>Prekinut</status><financ_value>121.640,45 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Javno zdravstvo i zdravstvena zaštita, Kliničke medicinske znanosti, Dentalna medicina, </scie_field_hr><scie_field_en>Public health and health services, Clinical sciences, Dental medicine, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Split School of Medicine]]></institution_en><team_members_id>65, 3182, 4547, 2679, 24041, 24088, 24104, 24136, 19211, 24198, 22661, 5404, 24221, 4096, 865290, </team_members_id><team_members_names><![CDATA[Joško Božić, Viktor Čulić, Renata Pecotić, Mladen Boban, Daniela  Šupe-Domić, Roko Duplančić, Maja Vajagić, Mario Podrug , Tea Galić, Damir Ivanković, Marija Roguljić, Tina Poklepović Peričić, Darko Božić, Varja Đogaš, Pjero Koren, ]]></team_members_names><keywords_hr><![CDATA[kardiovaskularni rizik, primarna i sekundarna prevencija, vaskularni biomarkeri, unapređenje procjene rizika, inovativni modeli   ]]></keywords_hr><keywords_en><![CDATA[cardiovascular risk, primary and secondary prevention, vascular biomarkers,  improvement in risk assessment, innovative models]]></keywords_en><summary_hr><![CDATA[Hrvatska ima visok mortalitet od kardiovaskularnih bolesti i stopu izbježive smrtnosti. Točna procjena ukupnog kardiovaskularnog (KV) rizika omogućuje rano otkrivanje osoba s rizikom i izbor optimalne preventivne skrbi. Tradicionalni modeli procjene KV rizika predviđaju rizik na razini populacije, ali nisu dovoljno točni u utvrđivanju rizika za pojedinca. Vaskularni biomarkeri (VB), pokazatelji ranog vaskularnog starenja, imaju velik potencijal za preciznije predviđanje pojedinačnog rizika.Projekt predviđa razvoj dva inovativna modela za procjenu KV rizika temeljena na VB, kao nadopunu tradicionalnim pristupima. Slučajno ćemo uzorkovati populaciju odraslih zdravstvenih osiguranika u Splitu i sakupiti njihove podatke o čimbenicima KV rizika, VB i drugim stanjima povezanim s vaskularnim oštećenjem, kao što su parodontitis, opstruktivna apneja u spavanju te kardiometabolički rizik. Model1 temelji se na robusnom grupiranju ispitanika s obzirom na različite VB što smo već opazili u velikoj kohortnoj studiji na populaciji Splita i što ukazuje na zajedničku vaskularnu strukturu unutar skupine. Testirat ćemo: a) replicira li se fenomen u našem uzorku, b) odražava li grupiranje stupanj vaskularne štete; c) je li u korelaciji s tradicionalnim modelom KV rizika. Model2 obuhvaća izradu normativnih jednadžbi centralnog augmentacijskog indeksa - surogatne mjere arterijske elastičnosti, na ispitanicima s niskim KV rizikom uz korištenje regresijskih modela specifičnih za spol i dobnu dekadu te uz dodatni prediktor što bi trebao poboljšati preciznost stratifikacije KV rizika. Modeli će se procjenjivati neizravno, putem slaganja sa SCORE modelom te procjenom njihove povezanosti s brojnim pokazateljima vaskularnog oštećenja. Provest će se i mnoštvo epidemioloških istraživanja.Očekujemo da ćemo izraditi obećavajuće modele za unapređenje procjene KV rizika, unaprijediti  znanje o epidemiologiji ispitivanih stanja i dati doprinos javno-zdravstvenim intervencijama utemeljenim na dokazima.]]></summary_hr><summary_en><![CDATA[Croatia is country with high burden of cardiovascular diseases, and amenable mortality. An accurate assessment of total cardiovascular (CV) risk enables early detection of people at risk and choice of optimal preventive treatment. Conventional models of CV risk assessment predict population attributable risk but lack sensitivity or specificity in identifying individual’s risk. Vascular biomarkers such as arterial stiffness indices are hallmarks of early vascular aging and have potential to predict this risk more accurately.We propose two innovative models for CV risk assessment that are based on vascular biomarkers and intended to complement traditional approaches. We will randomly sample adult primary care population from Split and collect data on CV risk factors, vascular biomarkers, and other conditions associated with vascular damage such as periodontitis and obstructive sleep apnea diagnoses, cardiometabolic risk. Model 1 is based on robust clustering of subjects according to various vascular biomarkers we had observed in large cohort; implying common vascular structure in a cluster. We will test if: a) phenomenon is replicated in our sample, b) clustering reflects the gradation of vascular damage; c) is correlated to traditional CV risk stratification model (SCORE). Model 2 foresees building of normative equations of central augmentation index, a surrogate measure of arterial stiffness, on data of low CV risk participants by using sex- and age-decade specific regression models and additional predictor which should improve precision of CV risk stratification. Models will be assessed indirectly via agreement with the SCORE model; and by evaluating their associations with numerous indicators of vascular damage. A multitude epidemiological research will also be performed.We expect to generate promising models for CV risk assessment, improve existing knowledge on epidemiology of screened conditions, and provide input for evidence-based public health interventions.]]></summary_en></project><project>
<id>7629</id><title_hr><![CDATA[Lipidi hrane, spol i dob u patogenezi metaboličkog sindroma]]></title_hr><title_en><![CDATA[]]></title_en><user_id>12663</user_id><user_firstLast_name>Kristina Starčević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-6623</code><acronim><![CDATA[DietMetSyn]]></acronim><duration>03.09.2018 - 20.03.2024</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Veterinarska medicina, </scie_field_hr><scie_field_en>Veterinary medicine, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Veterinarski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Veterinary Medicine]]></institution_en><team_members_id>25364</team_members_id><team_members_names><![CDATA[ Doktorand: Petra Roškarić ]]></team_members_names><keywords_hr><![CDATA[Lipidi, metabolički sindrom, hrana, miRNA, kronična upala, rezistencija na inzulin]]></keywords_hr><keywords_en><![CDATA[Lipids, metabolic syndrome, food, miRNA, cronic inflammation, insulin resistence]]></keywords_en><summary_hr><![CDATA[Poremećaj metabolizma lipida ključna je komponenta u razvoju metaboličkog sindroma pa je i prevalencija metaboličkog sindroma povezana sa stupnjem pretilosti. Stoga, promjene u sastavu hrane mogu biti važna strategija za prevenciju metaboličkog sindroma i posljedičnih bolesti.Pretilost nastaje tijekom dugotrajne pozitivne energetske ravnoteže koja potiče proupalni odgovor. To uzrokuje kroničnu upalu i pojačani dotok lipida iz masnog tkiva u jetru, mišićno tkivo i gušteraču što rezultira s glukotoksičnosti i lipotoksičnosti. Kronična upala i rezistencija na inzulin danas su prepoznati kao bitni čimbenici kod mnogih bolesti kao što su dijabetes tipa 2, kardiovaskularne bolesti, Alzheimerove bolesti i tumora.Za postizanje ciljeva projekta istražit ćemo nekoliko interakcija važnih za patogenezu metaboličkog sindroma: A) utjecaj n3/n6 omjera lipida hrane i dodavanja DHA kao prevencije metaboličkog sindroma, B) utjecaj n3/n6 omjera lipida hrane i dodavanja DHA kao moguće terapije metaboličkog sindroma, C) prijenos sklonosti razvitku metaboličkog sindroma i prekomjerne tjelesne mase s roditelja na potomstvo kao i utjecaj prehrane potomstva na težinu poremetnji prije i nakon spolne zrelosti, D) interakciju između dobi i metaboličkog sindroma i E) metabolizam lipida u tumorskom tkivu i tumorske markere lipidnog porijekla kao moguću vezu između pretilosti, metaboličkog sindroma, kronične upale i tumora.Naposlijetku, podaci iz cijelog projekta rezultirat će integracijom stečenih znanja iz svih pokusa i boljem razumijevanju složenosti patogeneze metaboličkog sindroma. Integrativni pristup omogućit će nove pristupe prevenciji i liječenju metaboličkog sindroma putem modifikacije prehrane kao i bolje razumijevanje veze između kronične upale izazvane pretilošću i tumora.]]></summary_hr><summary_en><![CDATA[Dysfunction of lipid metabolism is a key component in the development of metabolic syndrome and the prevalence of metabolic syndrome is strongly associated with the severity of obesity. Therefore, dietary intervention could be important strategy for the prevention of metabolic syndrome and associated diseases.Obesity arises from a sustained positive energy balance which triggers a pro-inflammatory response. These disturbances culminate in impaired insulin signaling, dysregulated glucose homeostasis and consequent development of insulin resistance. Chronic inflammation and insulin resistance are now recognized as contributing factors to many modern diseases such as insulin non dependent diabetes mellitus, cardiovascular diseases, Alzheimer disease and cancer. To achieve project objectives we will investigate several interactions that take place in metabolic syndrome pathogenesis: A) Influence of dietary n6/n3 ratio and DHA as a preventive mechanism on the severity of metabolic syndrome, B) Influence of dietary n6/n3 ratio and DHA on therapy of induced metabolic syndrome, C) Parental transmission of predisposition to obesity-related disorders to their offspring and influence of offspring diet on severity of metabolic disorders before and after sexual maturity, D) Interaction between age and metabolic syndrome and E) Cancer lipid metabolism and cancer markers of lipid origin as well as possible link between obesity, metabolic syndrome, low grade chronic inflammation and cancer.Finally, data from the whole project will result in the integration of gained knowledge from all experiments and in better understanding of complex pathogenesis of metabolic syndrome. Integrative approach will allow us to suggest new approaches to dietary prevention and therapy of metabolic syndrome and to better understand underlying link between obesity related chronic inflammation and cancer.]]></summary_en></project><project>
<id>7631</id><title_hr><![CDATA[Razvoj i toplinska svojstava inteligentne odjeće]]></title_hr><title_en><![CDATA[Development and thermal properties of intelligent clothing]]></title_en><user_id>3850</user_id><user_firstLast_name>Dubravko Rogale</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-6363</code><acronim><![CDATA[ThermIC]]></acronim><duration>01.01.2019 - 31.05.2023</duration><status>Završio</status><financ_value>109.907,76 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Tekstilna tehnologija, Temeljne tehničke znanosti, </scie_field_hr><scie_field_en>Textile technology, Basic engineering sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Tekstilno-tehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Textile Technology]]></institution_en><team_members_id>5611, 5992, 6964, 4448, 4273, 24165, 857, 3644, 26338, </team_members_id><team_members_names><![CDATA[Snježana  Firšt Rogale, Željko Knezić, Antoneta Tomljenović, Martina  Bobovčan Marcelić, Siniša Fajt, NIKOLINA JUKL, Kristina Krulić Himmelreich, Emilija Zdraveva, Daniel  Časar Veličan, ]]></team_members_names><keywords_hr><![CDATA[inteligentna odjeća, toplinska svojstva, termalni maneken,  vruća ploča, toplinski konduktometar, visokotehnološke metode spajanja odjeće]]></keywords_hr><keywords_en><![CDATA[intelligent clothing, thermal properties, thermal mannequin, hot plate, heat conductor, high-tech joining methods of clothing]]></keywords_en><summary_hr><![CDATA[Tim znanstvenika na Tekstilno-tehnološkom fakultetu bavi se razvojem potpuno nove vrste odjeće nazvane inteligentna odjeća s adaptivnim termoizolacijskim svojstvima. Razvili su i patentirali dvije generacije funkcionirajućih prototipova gdje senzori prate stanje vanjskog okoliša i mikroklime inteligentne odjeće, kao i trenutačno stanje tehničkih podsustava u odjeći. Stanje interpretira ugrađeno računalo, donosi zaključke o njemu te donosi odluke o potrebnim promjenama kako bi odjevni predmet smisleno reagirao i automatski adaptirao svoja toplinska svojstva u skladu sa stanjem okoliša i fizičke aktivnosti nositelja. Početna istraživanja i razvoj ukazala su na opravdanost uvođenja koncepcije inteligentne odjeće, a prototipovi i dijelovi mjeriteljske opreme dobili su priznanje međunarodne inovacijske zajednice nizom nagrada.Ciljevi ovog projekta su usavršavanje gradbene arhitekture sustava senzor-računalo-aktuator, izrada novih ergonomski oblikovanih segmentiranih termoizolacijskih komora i tehničkih podsustava korištenjem visokotehnoloških metoda spajanja te uspostava prototipa nove generacije inteligentne odjeće.Potom će se istražiti rad i karakteristike tehničkih podsustava i uspješnosti reakcija inteligentne odjeće s adaptivnim toplinskim svojstvima.  Za to će biti potrebno uspostaviti više novih mjernih metoda i protokola za mjerenje toplinskih svojstava te uspostaviti istraživački laboratorij za cjelovita mjerenja toplinskih svojstava odjeće. Stoga će se izvesti integracija svih mjeriteljskih podsustava u novoj klima komori podesivih parametara. Na temelju tih istraživanja izvest će se završno optimiranje reakcija inteligentne odjeće i određivanje njezinih svojstava pri promjenjivim uvjetima okoliša u laboratorijskim uvjetima i pri fizičkoj aktivnosti nositelja.Konačan cilj projekta je izrada usavršenog prototipa i istraživanje karakteristika nove vrste inteligentne odjeće te uspostava laboratorija za ispitivanje toplinskih svojstava svih vrsta odjeće.]]></summary_hr><summary_en><![CDATA[A team of scientists of the Faculty of Textile Technology is dealing with the development of an intelligent clothing with adaptive thermal insulation properties. They have developed and patented two generations of prototypes where sensors monitor the state of outdoor environment and the microclimate of intelligent clothing. The integrated computer interprets the existing situation, and it makes decisions about necessary changes so that the article of clothing intelligently responds and automatically adapts its thermal properties in accordance with the environment and physical activities of the wearer. Initial research activities and development have shown the justification of introducing the concept of intelligent clothing, while prototypes and parts of metrology equipment have been recognized by the innovation community with awards. The objectives of this project are to improve the architecture of the sensor-computer-actuator system, to design new ergonomically shaped segmented thermal insulation chambers and technical subsystems using high-tech welding methods and to create a new generation of intelligent clothing prototypes. The operation and characteristics of the technical subsystems and the reaction rate of intelligent clothing will be investigated. A new research laboratory for complete measurements of thermal properties of clothing shall also be established. The integration of metrology subsystems will be performed in the new climatic chamber. On the basis of these research activities, the final optimization of the reactions of intelligent clothing will be performed, and its properties in changing environmental conditions under laboratory conditions and during physical activities of the wearer will be determined. The final objective of this project is to create a sophisticated prototype and to study the properties of new kind of intelligent clothing and to establish a new laboratory for testing thermal properties of all types of clothing.]]></summary_en></project><project>
<id>7633</id><title_hr><![CDATA[Implicitna ličnost, donošenje odluka i vođenje u organizacijama]]></title_hr><title_en><![CDATA[Implicit personality, decision making and organizational leadership]]></title_en><user_id>3974</user_id><user_firstLast_name>Zvonimir Galic</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-9354</code><acronim><![CDATA[IMPEDEMOL]]></acronim><duration>01.12.2018 - 30.04.2023</duration><status>Završio</status><financ_value>79.208,97 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Psihologija, </scie_field_hr><scie_field_en>Psychology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>23666, 6601, 22773, 5480, 13589, 4979, 6848, 5575, 27640, </team_members_id><team_members_names><![CDATA[Nikola Erceg, Maja Parmač Kovačić, Mitja Ružojčić, Andreja Bubić, Maja Klindžić, Nataša Trojak, Željko Jerneić, Tomislav Hernaus, Antun Palanović, ]]></team_members_names><keywords_hr><![CDATA[vođenje u organizacijama, implicitna ličnosti, motiv za moći, testovi uvjetovanog rezoniranja,  individualne razlike u donošenju odluka]]></keywords_hr><keywords_en><![CDATA[organizational leadership, implicit personality, power motive, conditional reasoning tests,  individual differences in decision-making]]></keywords_en><summary_hr><![CDATA[Menadžeri i rukovoditelji u organizacijama odgovorni su za motiviranje zaposlenika, donošenje kvalitetnih odluka i izgradnju timova koji će s vremenom postizati dobre rezultate. Oni su ključni za uspjeh i razvoj tvrtki, kao i za motivaciju i dobrobit podređenih. Ipak, istraživanja pokazuju da je više od pola menadžera neuspješno u svom poslu te ili sami daju otkaz ili bivaju otpušteni. Također, neke studije ukazuju na to da čak 50% odluka koje donesu visokopozicionirani menadžeri rezultiraju neuspjehom. Neovisno o sektoru ili poziciji unutar organizacijske hijerarhije, razlozi za neuspjeh menadžera uglavnom su povezani s nekim njihovim psihološkim karakteristikama.Smatramo da rukovoditelji utječu na organizacijske ishode putem skupa kompetencija koje čine njihov rukovoditeljski potencijal. Rukovoditeljski potencijal dijelom ovisi o ličnosti i kompetentnosti u  donošenju odluka. Kroz ovaj projekt, pokušat ćemo istražiti mogu li novije spoznaje u području mjerenja implicitne ličnosti doprinijeti istraživanju rukovođenja u organizacijama. Također, u skladu s novijim prijedlozima o potrebi integracije spoznaja iz područja psihologije rada i organizacijske psihologije s onima iz područja prosuđivanja i donošenja odluka, istražit ćemo kako je uspješnost u rukovođenju povezana s individualnim razlikama u odlučivanju.Kao ishod ovog projekta, planiramo razviti i empirijski validirati bateriju psihologijskih testova za odabir i razvoj menadžera, koja će biti bazirana na najnovijim znanstvenim spoznajama u području selekcije i menadžmenta. Baterija će se sastojati od testova implicitne ličnosti temeljenih na paradigmi uvjetovanog rezoniranja, instrumenata za mjerenje individualnih razlika u donošenju odluka i testa situacijskih prosudi za procjenu rukovoditeljskog potencijala.]]></summary_hr><summary_en><![CDATA[Managers or organizational leaders are responsible for motivating their employees, making good decisions, and building teams that produce results over time. They are crucial for success and development of companies as well as for motivation and well-being of their subordinates. Still, recent research shows that about half of managers are unsuccessful in their jobs and either resign or get fired. Moreover, some studies showed that important decisions by top managers in at least 50% of cases result with failure.  Irrespective of the type of industry or exact level of the position in an organizational hierarchy, the reasons for managerial derailment are typically related to some psychological characteristics of the leaders.We believe that leaders affect organizations through a set of competencies that make their leadership potential, and that, in turn, determine their performance.  The leadership potential and leadership performance are to a large extent a function of leaders’ personality, and decision-making competencies. Within the project, we will try to explore how recent advances in implicit personality assessment could contribute to organizational leadership research. Moreover, in accordance with recent calls to integrate work and organizational psychology with decision-making literature, we will try to explore how is leadership performance related to individual differences in decision-making. As an outcome of this research project, we plan to develop and empirically test a battery of psychological instruments for selection and development of managers that is based on recent advances in personnel selection and management literature. The battery will consist of the tests of implicit personality based on the conditional reasoning paradigm, instruments for measurement of individual differences in decision-making and a situational judgment test for the assessment of leadership potential.]]></summary_en></project><project>
<id>7634</id><title_hr><![CDATA[Asimptotička analiza rubnih problema u mehanici kontinuuma]]></title_hr><title_en><![CDATA[Asymptotic analysis of boundary value problems in continuum mechanics]]></title_en><user_id>1462</user_id><user_firstLast_name>Eduard Marušić-Paloka</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-2735</code><acronim><![CDATA[ASAN]]></acronim><duration>01.10.2018 - 30.09.2022</duration><status>Završio</status><financ_value>94.498,64 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, Fizika, Biologija, </scie_field_hr><scie_field_en>Mathematics, Physics, Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>4816, 22664, 23314, 817, 3424, 864969, </team_members_id><team_members_names><![CDATA[Josip Tambača, Marko Radulović, Matko Ljulj, Igor Pažanin, Andrijana Ćurković, Jean Carlos Nakasato, ]]></team_members_names><keywords_hr><![CDATA[asimptotička analiza, mehanika kontinuuma, rubni problemi, parcijalne diferencijalne jednadžbe, matematičko modeliranje]]></keywords_hr><keywords_en><![CDATA[asymptotic analysis, continuum mechanics, boundary value problems, partial-differential equations, mathemetical modeling]]></keywords_en><summary_hr><![CDATA[Cilj ovog projekta je koristiti asimptotičke metode za izvod efektivnih modela koji opisuju razne procese u mehanici kontinuuma. Istraživanje je podijeljeno u 7 cjelina koje su opisane sljedećim ciljevima: Cilj 1. Perturbacija ruba i Darcy-Weisbachov zakon. Koristeći perturbacijske tehnike razvijene u [24] i [25] izvodimo formulu za računanje pada tlaka u cijevi, usljed trenja o stijenku. Cilj 2. Spoj tankih sudova ispunjenih fluidom. Uobičajena metoda za proučavanje tokova fluida kroz takva područja je izvođenje nižedimenzionalnih modela. Planiramo koristiti sličan pristup kakav je korišten u teoriji elastičnosti za izvođenje novih modela u mehanici fluida. Cilj 3. Nestacionarni tok mikropolarnog fluida. Idući cilj predložiti je nove efektivne modele višeg reda točnosti koji bi opisivali nestacionarni tok mikropolarnog fluida u tankim cijevima.Cilj 4. Neizotermni tok u poroznoj sredini. Motivirani brojnim inženjerskim primjenama, planiramo izučavati i prijenos topline u fluidu koji se kreće kroz poroznu sredinu. Cilj 5. Modeli interakcije elastičnih tijela. U ovom dijelu projekta radit ćemo na izvodu i opravdanju različitih modela interakcije elastičnih tijela različitih veličina. Cillj 6. Interakcija elastične ploče i tankog sloja kompresibilnog fluida.Ideja je razviti pojednostavljeni model za interakciju tankog sloja fluida i ploče koja se nalazi na dijelu ruba domene.]]></summary_hr><summary_en><![CDATA[We propose a research that uses rigorous asymptotic techniques for deriving effective models governing different processes in continuum mechanics. The research is separated in 6 parts defined by following goals: Goal 1. Boundary perturbation and the Darcy-Weisbach law.  Using the perturbation and homogenization methods developed , our first goal is to derive the effective law describing the pressure drop in the rough pipe, due to the friction on the boundary. Goal 2. Junctions of thin vessels filled with fluid.  We plan to use the methods applied in elasticity theory and hope to derive some new models. Goal 3. Non-stationary micropolar fluid flow. Our next goal is to propose new effective models of higher order of accuracy describing non-stationary flow of a micropolar fluid in thin pipe-like domains. Goal 4. Non-isothermal porous medium flow. Motivated by a broad range of engineering applications, we also intend to study heat transfer phenomena through fluid- saturated porous media. Goal 5. Interactions of elastic bodies. We will work on derivation and justification of  different models of interaction of elastic bodies of different sizes. For instance three-dimensional and thin plate-like elastic bodies or thin plate-like and thin rod-like elastic bodies. Goal 6.Interaction of an elastic plate and a thin layer of compressible fluid. The idea is to develop a simplified model for the interaction of the thin layer of fluid and the plate which is part of the fluid domain boundary.  ]]></summary_en></project><project>
<id>7635</id><title_hr><![CDATA[Utjecaj podrijetla i izolacije na ADME gene: primjer romske populacije]]></title_hr><title_en><![CDATA[]]></title_en><user_id>12348</user_id><user_firstLast_name>Marijana Peričić Salihović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-4817</code><acronim><![CDATA[ADMEROMA]]></acronim><duration>10.09.2018 - 31.12.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut za antropologiju]]></institution_hr><institution_en><![CDATA[Institute for Anthropological Research]]></institution_en><team_members_id>25214</team_members_id><team_members_names><![CDATA[ Doktorand: Anita Stojanović Marković ]]></team_members_names><keywords_hr><![CDATA[ADME geni, Romi, izolacija, populacijska struktura, polimorfizmi, CYP2D6, CYP1A2]]></keywords_hr><keywords_en><![CDATA[ADME genes, Roma, isolation, population structure, polymorphisms, CYP2D6, CYP1A2]]></keywords_en><summary_hr><![CDATA[Genomska raznolikost suvremenih populacija odražava demografske i evolucijske događaje u prošlosti što se posebno očituje u izoliranim populacijama. Romi su primjer populacije utemeljitelja u kojoj je višestoljetna sociokulturna izolacija ostavila tragove u zalihi gena, vidljive u znatnoj genskoj različitosti Roma od drugih populacija. ADME geni, odgovorni za apsorpciju, distribuciju, metabolizam i izlučivanje lijekova, ubrajaju se u one koji pokazuju značajnu varijabilnost među populacijama. Unatoč dokazanoj funkcionalnoj ulozi, znanje o njihovoj distribuciji u izoliranim populacijama vrlo je ograničeno. Stoga u ovom projektu namjeravamo istražiti polimorfizme ADME gena analizom temeljnih ADME biljega i gena CYP2D6 i CYP1A2 na uzorku od 300 osoba, pripadnika triju različitih romskih skupina iz Hrvatske. Glavni je cilj projekta odrediti varijacije ADME gena u romskoj populaciji kako bi se utvrdio utjecaj višestrukih učinaka utemeljitelja i uskog grla, izolacije i endogamije na ovu važnu skupinu gena. Taj cilj bit će postignut provedbom analize populacijske strukture, procjenom starosti mutacija i funkcionalnom analizom in silico. Očekujemo da ćemo pronaći specifične razdiobe alela istraživanih lokusa unutar ADME gena, kao i genske osobitosti koje odražavaju indijsko podrijetlo Roma te pokazatelje koji upućuju na tok gena između romske i drugih populacija s kojima su dolazili u doticaj tijekom migracija iz Indije u Europu. Novoutvrđeni ADME genski profil svojstven romskoj populaciji bit će važan za svakodnevnu medicinsku praksu pri modulaciji farmakoterapije. Također, dobiveni će rezultati doprinijeti farmakogenetici upotpunjavanjem slike o varijacijama ADME gena kod Roma te omogućiti primjenu tih spoznaja u razvoju farmakogenetičkih testova specifičnih za ovu manjinsku populaciju koja u svijetu broji preko 15 milijuna ljudi. Očekujemo da će rezultati istaknuti populacijsku specifičnost ADME gena i potaknuti provedbu takvih istraživanja u ostalim izolatima svijeta.]]></summary_hr><summary_en><![CDATA[Contemporary populations’ genomic diversity reflects past demographic and evolutionary events, pronounced in isolated populations. The Roma is an example of a founder population with centuries long sociocultural isolation which left traces in their gene pool which shows considerable differences compared with other populations. The genes that significantly differentiate among populations are those responsible for absorption, distribution, metabolism and excretion of drugs (ADME genes). The knowledge on their distribution in isolated populations is limited. Therefore, in this application we propose to study ADME genes&#39; polymorphisms through the analysis of ADME core markers and CYP2D6 and CYP1A2 genes in 300 DNA samples obtained from three Roma groups in Croatia. The general objective of this project is to determine the variation of ADME genes in Roma population, to assess the extent to which the population history which includes multiple bottleneck/founder events, isolation and endogamy impacted this important gene family. This will be achieved through population structure analysis, the assessment of the age of mutations and in silico functional analysis. We expect to find specific allele distributions of the investigated loci within the ADME genes, landmarks that reflect the Indian origin of the Roma and the signals of admixture with the populations they came in close contact with in the past during their migration from India to Europe. Our assessment of Roma’ unique genetic profile will contribute to the medical practice through the modulation of pharmacotherapy in Roma population. It will also significantly contribute to the field of pharmacogenetics in terms of information on the genetic variation in Roma, essential for the development of pharmacogenetic tests specific for this minority population estimated to around 15 million people. The results promise to highlight the population uniqueness in ADME genes and encourage similar research in the world’s isolates.]]></summary_en></project><project>
<id>7637</id><title_hr><![CDATA[EVOLUCIJA UPALNOG ARTRITISA U DJECE: ULOGA OSNAŽENOGA MUSKULOSKELETNOGA ULTRAZVUKA TE EPIGENETSKIH, PROTEINSKIH I DISBIOTIČKIH BIOMARKERA U RAZVOJU JUVENILNOG IDIOPATSKOG ARTRITISA]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4768</user_id><user_firstLast_name>Miroslav Harjaček</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-9203</code><acronim><![CDATA[childARTHRITISevolve]]></acronim><duration>27.10.2018 - 26.10.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Clinical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>25390</team_members_id><team_members_names><![CDATA[ Doktorand: Domagoj Buljan ]]></team_members_names><keywords_hr><![CDATA[juvenilni idiopatski artritis, nediferencirani artritis, epigenetika, proteomika, disbioza, ultrazvuk, biomarkeri]]></keywords_hr><keywords_en><![CDATA[juvenile idiopathic arthritis, undifferentiated arthritis, epigenetics, proteomics, dysbiosis, ultrasound, biomarkers]]></keywords_en><summary_hr><![CDATA[Juvenilni idiopatski artritis (JIA) najčešća je reumatska bolest dječje dobi. Kako bi se spriječilo oštećenje zglobova te razvoj funkcionalne nesposobnosti, jedan od glavnih ciljeva u liječenju bolesti postao je rano postavljanje dijagnoze te odabir učinkovite i poštedne terapije. Nažalost, na samom početku bolesti trenutno je vrlo teško odrediti kako će bolest napredovati. Dosada je provedeno mnogo istraživanja koja su pokazala da u podlozi bolesti leži kompleksna disregulacija imunološkog sustava do koje dolazi zbog utjecaja genetskih i okolišnih čimbenika. Ipak, još smo daleko od jasne slike mehanizama koji predisponiraju dijete za razvoj bolesti, pogoršanje simptoma ili za dobar odgovor na pojedini oblik liječenja. Cilj ovoga projekta stoga je u krvi, stolici, slini i sinovijalnoj tekućini bolesnika otkriti različite epigenetske i proteinske biomarkere te odrediti vrijednost osnaženog muskuloskeletnog ultrazvuka (engl. power-doppler ultrasound) i različitih kliničkih pokazatelja u otkrivanju ranih promjena i predviđanju tijeka bolesti. U istraživanju će sudjelovati 17 bolesnika s nediferenciranim artritisom (NA) i 33 bolesnika s razvijenim JIA koji će biti praćeni tijekom dvije godine. U više vremenskih točaka ispitat će se epigenetski mehanizmi (metilacija, histonska modifikacija) regulacije ključnih čimbenika transkripcije i fosfataza koji se povezuju s razvojem bolesti te izražaj nekodirajućih RNA. Nadalje, u više navrata će se provesti i analize proteoma pomoću masene spektometrije, a odabrani proteini analizirati će se pomoću komplementarnih metoda. Rezultati ovog sveobuhvatnog projekta pružit će nam bolji uvid u kompleksne mehanizme u podlozi bolesti te otkriti potencijalne epigenetske, proteinske i disbiotičke biomarkere koji će nam omogućiti ranije postavljanje dijagnoze te bolje klasificiranje bolesti i predviđanje odgovora na liječenja. Naposljetku, dobiveni rezultati mogli bi nam omogućiti i otkrivanje novih načina liječenja ove nepredvidive bolesti.]]></summary_hr><summary_en><![CDATA[Juvenile idiopathic arthritis (JIA) is the most common childhood rheumatic disease. The early diagnosis of new-onset JIA has become a major objective for pediatric rheumatologists in order to identify a management strategy able to change the natural history of the disease and to prevent joint damage and functional impairment. The term undifferentiated arthritis (UA) is applied to the most common type of arthritis at the early stage when, in the absence of current recommended diagnostic criteria, it cannot be classified into the clinical subtypes of JIA. Patients with UA may progress towards JIA; however in some cases arthritis may completely resolve. Many studies has shown important role of immune system dysregulation influenced by genetic and environmental factors, but we are still far from having a clear picture of the molecular network that predisposes a child to develop the disease, to worsen the symptoms, or to successfully respond to a specific treatment. The goal of this project is to identify various epigenetic, protein and dysbiotic biomarkers in blood, stool, saliva and synovial fluid of 17 UA and 33 JIA patients, along with the value of power-doppler ultrasound (PDUS) and clinical assessment tools in the prediction of disease evolution. Therefore, we will analyze epigenetic modifications (methilatyon and histone modifications) of transcription factors and phosphatases with a known role in disease development, as well as microRNA expression profiles. Furthermore, to elucidate the possible role of other proteins, proteome will be analyzed by mass spectrometry, and selected proteins will be confirmed by complementary methods. The results of this comprehensive project will provide new insights into complex pathophysiology of JIA and enable us to use epigenetic, protein and dysbiotic biomarkers for better diagnosis, classification and treatment response prediction. In addition, results of the project may help to identify potentially new therapeutic targets.]]></summary_en></project><project>
<id>7639</id><title_hr><![CDATA[Makrozoni, novi konjugati makrolidnih antibiotika: Dizajn, priprava i interakcije]]></title_hr><title_en><![CDATA[Macrozones, New Conjugates of Macrolide Antibiotics: Design, Synthesis and Interactions]]></title_en><user_id>1106</user_id><user_firstLast_name>Predrag Novak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-8098</code><acronim><![CDATA[Makrozoni/Macrozones]]></acronim><duration>01.10.2018 - 31.01.2023</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, Interdisciplinarne prirodne znanosti, </scie_field_hr><scie_field_en>Chemistry, Interdisciplinary natural sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>47, 3260, 3144, 19148, 1387, 19297, 3242, 3022, 28650, 20946, </team_members_id><team_members_names><![CDATA[Marina Cindrić, Katarina Pičuljan, Tomislav Jednačak, Iva Habinovec, Jelena Parlov Vuković, Ivančica Kovaček, Mirjana Bukvic, Klaus Zangger, Ivana Mikulandra, Kristina Smokrović, ]]></team_members_names><keywords_hr><![CDATA[makrozoni, dizajn, priprava, bioaktivnost, interakcije]]></keywords_hr><keywords_en><![CDATA[macrozones, design, synthesis, bioactivity, interactions]]></keywords_en><summary_hr><![CDATA[Porast bakterijske rezistencije na postojeće antibiotike danas predstavlja vrlo ozbiljan globalni problem u čije se rješavanje uključila i svjetska zdravstvena organizacija WHO. Zabrinjavajuća je činjenica da je u posljednjih desetak godina otkriveno svega nekoliko novih antibiotika što uskoro za posljedicu može imati povećanu smrtnost čak i od običnih infekcija. Stoga je potrebno uložiti znatne napore u istraživanja koja imaju za cilj prevladavanje bakterijske rezistencije. Naši preliminarni rezultati su pokazali da postoji veliki potencijal za istraživanje konjugata makrolidnih antibiotika. Sukladno tome, cilj predloženog projekta je dizajn, priprava i interakcije makrozona, novih bioaktivnih konjugata makrolidnih antibiotika i tiosemikarbazona. Planirana istraživanja uključujuju: sintezu konjugata njihovim povezivanjem na odabranim ključnim mjestima; određivanje njihove strukture i karakterizaciju u čvrstom stanju i otopini; istraživanje njihove stabilnosti i interakcija s biološkim metama; biološka ispitivanja i određivanje odnosa strukture i biološke aktivnosti kao preduvjet za dizajn novih bioaktivnih spojeva. Važnost istraživanja je i u činjenici da će sustavno određivanje odnosa kemijske strukture i biološke aktivnosti, s naglaskom na utjecaju položaja tiosemikarbazonskog supstituenta, na promjenu bioloških svojstava i vezanja na biološku metu dati nove spoznaje i omogućiti razvoj bioaktivnih spojeva. Očekuje se da će suradnja znanstvenika u predloženim interdisplinarnim istraživanjima stvoriti centar izvrsnosti u ovom području znanosti, čime će se proširiti i baza ekspertize u području medicinske kemije i otkrića novih antibiotika. Rezultati koji se očekuju u sklopu predloženog projekta omogućit će stjecanje novih znanja s mogućnošću patentiranja i praktične primjene u zdravstvu i farmaceutskoj industriji. ]]></summary_hr><summary_en><![CDATA[Emerging multi-drug resistant microbes present today a serious and challenging global problem which demand novel antimicrobial agents to be discovered. The WHO has recognized the threat and issued recently a report warning that even minor injuries could become lethal. In the last ten years just nine new antibiotics have been approved which was significantly less than decades before and not enough new ones are being developed to counter resistance. Our preliminary result have shown a great antibacterial potential of new macrolide antibiotic conjugates, the macrozones. Hence, the main objective of the proposed project is design, preparation and interactions of new classes of bioactive macrolide antibiotic conjugates by linking azithromycin and clarithromycin to thiosemicarbazone at key positions. The proposed rearch is interdisciplinary since it includes a) preparation of new conjugates, b) their complete characterisation in solution and solid state, c) evaluation of their biological properties and interactions with biological receptors and d) establishing structure activity relationships as a basis for design of molecules with better biological activity. The importance of this project also lies in the fact that establishing structure-activity relationships by systematic determination of influence of the position of thiosemicarbazone moiety at azalide/macrolide ring to antimicrobial activity will provide new insights into their binding and enable new bioactive molecules to be discovered. By joining different expert teams from synthetic and structural chemistry to biology and medicine this project will benefit and we expect that it will provide new scientific discoveries and knowledge that can further be exploited in practice to develop medical products based on high technology. We believe that investigations performed in the project and the cooperation of research groups will create centre of excellence in the field of medicinal chemistry and antibiotic drug design.]]></summary_en></project><project>
<id>7640</id><title_hr><![CDATA[Generalizirana geometrija i simetrije]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5035</user_id><user_firstLast_name>Athanasios Chatzistavrakidis</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-3001</code><acronim><![CDATA[GGSymm]]></acronim><duration>16.10.2018 - 15.10.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>25315</team_members_id><team_members_names><![CDATA[ Doktorand: Georgios Karagiannis ]]></team_members_names><keywords_hr><![CDATA[generalizirana kompleksna geometrija, nekomutativna geometrija, baždarne teorije, matrični modeli, fuzzy prostorir]]></keywords_hr><keywords_en><![CDATA[generalized complex geometry, non-commutative geometry, gauge theory, matrix models, fuzzy spaces]]></keywords_en><summary_hr><![CDATA[Ujedinjenje Einsteinove teorije opće relativnosti s kvantnom fizikom predstavlja jedan od najvećih izazova moderne teorijske fizike. Jedna pretpostavka zajednička svim istraživačkim smjerovima usmjerenih ka razumijevanja kvantne teorije gravitacije jest  da  za  opis geometrije prostor-vremena nije dostatna  klasična slika prostor-vremena kao diferencijabilne mnogostrukosti. U okviru ovog projekta smo zainteresirani za generalizirane geometrije motivirane fizikom teorije struna; generalizirana kompleksna geometrija i nekomutativna geometrija. Naš cilj jest  bolje razumijevanje  kako spomenute ideje generalizirane geometrije   iskoristiti u generalizaciji načela simetrije. Konkretno, zainteresirani smo za proširenje baždarnog principa, ključne ideje koji se koristi u fizici za opis svih (poznatih) međudjelovanja materije, a u svjetlu ovih proširenja klasične geometrije. Želimo opisati učinke dualnosti u teoriji struna, nekomutativne baždarne teorije te  viših baždarnih teorija u okviru učinkovne teorija polja koja nam je potrebne za obavljanje pouzdanih izračuna koje je moguće eksperimentalno provjeriti. Očekujemo da će nam geometrizacija ovih poopćenih simetrija pružiti, u dugogodišnjoj perspektivi, konzistentan okvir unutar kojeg bi se mogla riješiti neka od otvorenih pitanja u kozmologiji i fizici crnih rupa.]]></summary_hr><summary_en><![CDATA[The unification of Einstein&#39;s theory of general relativity with quantum physics represents one of the greatest challenges of modern theoretical physics. A hypothesis common to all research directions aiming at understanding the quantum theory of gravity is that our description of space-time geometry has to go beyond the classical picture of space-time as a differentiable manifold.  Within this project we are interested in generalized concepts of geometry, physically motivated by string theory: generalized complex geometry and non-commutative geometry. We aim at improving our understanding on how these generalized notions of geometry could be utilized to obtain consistent extensions of symmetry principles. In particular, we are interested in extending the gauge principle, the key physical notion used to describe all (known) matter interactions, in view of the above generalizations of classical geometry. Our goal is to capture the effects of string duality symmetries, non-commutative gauge theory and higher gauge theories at the level of the effective field theory description, which is necessary in order to perform reliable calculations and yield experimentally testable predictions. We expect that geometrizing these generalized symmetries would provide us, as a long-term perspective, with a consistent framework within which one could address open issues in cosmology and black-hole physics.]]></summary_en></project><project>
<id>7642</id><title_hr><![CDATA[Istraživanje antioksidativnog djelovanja benzazolskog skeleta u dizajnu novih antitumorskih agensa]]></title_hr><title_en><![CDATA[Exploring the antioxidative potential of benzazole scaffold in the design of novel antitumor agents ]]></title_en><user_id>2914</user_id><user_firstLast_name>Marijana Hranjec</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-4379</code><acronim><![CDATA[AntioxPot]]></acronim><duration>01.12.2018 - 31.03.2023</duration><status>Završio</status><financ_value>131.926,47 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, Biologija, Interdisciplinarne prirodne znanosti, </scie_field_hr><scie_field_en>Chemistry, Biology, Interdisciplinary natural sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet kemijskog inženjerstva i tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Chemical Engineering and Technology]]></institution_en><team_members_id>2865, 2768, 2769, 23576, 613, 2607, 4012, 1099, 23747, 23963, 2811, 25735, 4391, 27497, 26992, 24377, </team_members_id><team_members_names><![CDATA[Livio Racané, Maja Cindrić, Nataša Perin, Lucija Ptiček, Marijeta Kralj, Irena Martin-Kleiner, Karmen Brajša, Ivana Novak Jovanović, Kristina Butković, Ines Vujasinović, Grace Karminski-Zamola, Ida Boček, Dragana Mutavdžić Pavlović, Kristina Tolić, Anja Beč, Katarina Zlatić, ]]></team_members_names><keywords_hr><![CDATA[sinteza, benzazoli, računalna kemija, antioksidativna aktivnost, antitumorska aktivnost]]></keywords_hr><keywords_en><![CDATA[synthesis, benzazoles, computational chemistry, antioxidative activity, antitumor activity]]></keywords_en><summary_hr><![CDATA[Predloženi znanstveni projekt usmjeren je na dizajn i razvoj novih i učinkovitih derivata benzazola kao antioksidansa s antitumorskom aktivnošću koji će biti dio antitumorske terapeutske strategije temeljene na inhibiciji ROS-a. Projekt je multidisciplinaran i okuplja interdisciplinarnu skupinu istraživača čija zajednička sinergija treba voditi do ostvarenja glavnih ciljeva projekta. Projekt će se sastojati od tri glavna cilja, uključujući sintezu i strukturnu karakterizaciju derivata benzazola, računalna istraživanja i određivanje biološke aktivnosti. Tijekom projekta sintetizirat će se mala biblioteka derivata benzazola, a dodatno će ovo zajedničko istraživanje rezultirati optimizacijom benzazolskog skeleta što bi trebalo osigurati bolju aktivnost i optimirana svojstva odabranih vodećih spojeva kao antioksidativnih i antitumorskih agensa. Računalna kemija i QSAR modeliranje omogućit će strukturnu optimizaciju odabranih vodećih spojeva. Biološka ispitivanja uključivat će in vitro metode za određivanje antioksidativne aktivnosti. Dodatno, odabranim spojevima odredit će se antiproliferativna aktivnost in vitro na humane stanice karcinoma. Da bi se dodatno objasnili mehanizmi biološkog djelovanja vodećih spojeva, provest će se procjena razine ROS-a u stanicama i mitohondrijima, analiza oksidativnih oštećenja DNK te procjena ekspresije proteina. Jedan od ciljeva projekta bit će i razvoj manje toksičnih derivata kao potencijalnih fluorescentnih proba za detekciju biomakromolekula. Zaključno, predstavljeno istraživanje temelji se na zajedničkim istraživanjima različitih institucija uključujući istraživače iz različitih znanstvenih područja. Predloženi projekt temelji se na istraživanju u području medicinske kemije, s naglaskom na moguća daljnja ciljana istraživanja kao i daljnji razvoj naše znanstvene skupine na međunarodnoj razini.]]></summary_hr><summary_en><![CDATA[The proposed scientific project is oriented towards the design and development of novel and efficient benzazole derivatives as antioxidants with antitumor activity as a part of antitumor therapeutic strategy based on inhibition of ROS. The project is highly multidisciplinary and brings together an interdisciplinary team of researchers whose common synergy will lead to the main goals of the project. The project will consist of three main objectives including synthesis and structural characterization of benzazole derivatives, computational research and biological evaluation. Within the project synthesis of small library of benzazole derivatives will be performed while additionally this collaborative research should result in the optimization of the benzazole scaffold which will ensure more efficient activity and optimized properties of lead compounds as antioxidants and antitumor agents. Computational chemistry and QSAR modelling will allow a structural optimization of chosen lead compounds. Biological evaluation will include in vitro assays for evaluation of antioxidative activity. Additionally, the chosen compounds will be tested for antitproliferative activity in vitro on human cancer cells. To get more insight into the mechanisms of action of lead compounds the assessment of ROS levels in the cells as well in mitochondria, along with the oxidative DNA damage and analysis of expression of proteins will be performed. One of the objectives will be the development of less toxic derivatives as potential fluorescent probes for detection of biomacromolecules. Finally, the presented research is based on joint research of different institutions including researchers from different scientific fields. Proposed project is based on the research in the field of medicinal chemistry with focus on possible further target research as well as further development of our scientific group on the international level.]]></summary_en></project><project>
<id>7643</id><title_hr><![CDATA[Novel Characterizations of Classical and Quantum Many-Body Systems]]></title_hr><title_en><![CDATA[]]></title_en><user_id>20277</user_id><user_firstLast_name>Fabio Franchini</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-7464</code><acronim><![CDATA[ManyBodyCharacteriza]]></acronim><duration>12.09.2018 - 11.11.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>25292</team_members_id><team_members_names><![CDATA[ Doktorand: Vanja Marić ]]></team_members_names><keywords_hr><![CDATA[mnogočestični sustavi, nered, lokalizacija, lavine, Isingov model u nasumičnom polju, neperturbativna renormalizacijska grupa, kvantno sprezanje]]></keywords_hr><keywords_en><![CDATA[Many-body systems, Disorder, Localization, Avalanches, Random Field Ising Model, Non-perturbative Renormalization Group, Entanglement]]></keywords_en><summary_hr><![CDATA[Više je različito napisao je P.W.Anderson godine 1972, objašnjavajući kako je glavni izazov moderne fizike razumjeti i opisati kako interakcija velikog broja elemenata dovodi do novih i kompleksnih ponašanja, koji se ne mogu objasniti preko ponašanja izvornih konstituenata.   Kako bismo identificirali najbolje varijable i pristupe nekoliko prototipskih modela, skupili smo stručnjake iz raznih aspekata kompleksih sustava.Koristit ćemo jednostavni model sa specifičnim svojstvima, kako bismo razumjeli odnos između novootkrivene vrste spontanog loma simetrije, lokalizacije i staklastog ponašanja, s primjenama u fizici čvrstog stanja i kompleksnih sustava (a možda i teoriji struna). Ovaj model je formuliran u preko članova velike matrice i već je prije povezan s metal/izolator prijelazom i Chern-Simons/topološkim teorijama struna. Nedavno je otkriveno kako je netrivijalni spontani lom simetrije koji se javlja u tom modelu odraz vrlo složenog energetskog krajolika, kojeg karakterizira parametarski velik broj ravnotežnih konfiguracija (sedla particijske funkcije). Takvo ponašanje je primjer kompleksnog sustava i može ga se opisati tim movim tipom loma simetrije.Paralelno tome istražiti ćemo jednodimenzionalni model s dugodosežnim interakcijama, kako bismo modelirali ponašanje Isingovog modela u nasumičnom polju i proučili critično ponašanje s naglaskom na fenomenologiju lavina. U ovom modelu efektivna dimenzija je enkodirana u parametru dosega interakcija, što nam dozvoljava prilagođavanje necjelobrojnoj dimenziji u kojoj se događa ponašanje koje nam je interesantno.Također ćemo se baviti jako interagirajućim kvantnim sustavima i njihovim svojstvima kvantnog sprezanja, kako bismo shvatili način na koji informacijska teorija može pomoći u razaznavanju specijalne prirode multi-kritičnih, ne-konformnih točaka. Kvantno sprezanje je suštinski povezano s kvantnim računanjem i koristit ćemo novu veličinu, koja se zove nelokalna konvertibilnost.]]></summary_hr><summary_en><![CDATA[More is Different wrote P.W. Anderson in 1972, explaining that the central challenge of modern physics is to understand how the interaction of a large number of elementary constituents can lead to the emergence of novel, complex behaviors, which can hardly be explained in terms of the original ingredients.In order to identify the appropriate variables and formalism to capture the behavior of a few prototypical toy models, we will assemble expertise in different types of complex systems.On one side, we will use a toy model understand the relation between a novel spontaneous symmetry breaking (SSB), localization and glassiness, with applications in condensed matter and complex systems. This model is formulated in terms of large matrices and has already been linked to the metal/insulator transition from one side, and to the Chern-Simons/topological string theories from another. More recently, it was understood that the conjectured nontrivial SSB realized in this model is the reflection of a complex energy landscape, characterized by a parametrically large number of equilibrium. Such a behavior is paradigmatic of a complex system and thus it can be captured by a new type of replica symmetry breaking.In a parallel effort, we will use a one dimensional model with long range interaction as a tool to model the behavior of the random field Ising model in different dimensions and to study the critical exponents and avalanche phenomenology. In the toy model, the effective dimension is encoded in decay rate of the long range interaction and thus allow for a fine tuning even to relevant “fractional” dimensions emerging from non-perturbative-RG.We will also tackle strongly interacting quantum systems and their entanglement properties, to understand how information theory can help in discriminating the special nature of multi-critical, non-conformal points and the computational power of topological phases through non-local convertibility.]]></summary_en></project><project>
<id>7644</id><title_hr><![CDATA[Izranjanje i poniranje u području srednjeg Jadrana]]></title_hr><title_en><![CDATA[Middle Adriatic Upwelling and Downwelling]]></title_en><user_id>3375</user_id><user_firstLast_name>Mirko Orlić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-9849</code><acronim><![CDATA[MAUD]]></acronim><duration>01.11.2018 - 30.04.2023</duration><status>Završio</status><financ_value>182.759,31 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Geofizika, </scie_field_hr><scie_field_en>Geophysics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>6846, 4997, 17753, 2983, 2761, 23420, 1315, 3525, 23787, 2662, 2898, 1417, 172, 23433, 6243, 4777, 12559, 23518, 774, 3007, 3031, 203, </team_members_id><team_members_names><![CDATA[Boris Antolić, Alica Bajić, Maja Bubalo, Tomislav Džoić, Branka Grbec, Petra Lučić, Iva Međugorac, Hrvoje Mihanović, Stipe Muslim, Živana Ninčević Gladan, Miroslava Pasarić, Zoran Pasarić, Mladen Šolić, Jere Veža, Olja Vidjak, Ante Žuljević, Frano Matić, Antonio Stanešić, Martina Tudor, Gordana Beg Paklar, Žarko Kovač, Stefanija Šestanović, ]]></team_members_names><keywords_hr><![CDATA[Izranjanje/poniranje, numerčiko modeliranje, bentos, plankton, Jadran]]></keywords_hr><keywords_en><![CDATA[Upwelling/downwelling, numerical modelling, benthos, plankton, Adriatic]]></keywords_en><summary_hr><![CDATA[Proces izranjanja ima značajne posljedice za život u moru jer se uzlaznim gibanjem prenosi nutrijentima bogata voda iz dubine prema površini i tako potiče primarna produkcija, a onda i razvoj viših razina hranidbenog lanca. Biološka istraživanja 1980-ih dovela su u vezu obilje planktona, zone mrijesta srdele te velike ulove u području Blitvenice, s izranjanjem potpovršinske vode iz Jabučke kotline.Krajnji cilj projekta MAUD je stvoriti cjelovitu multidisciplinarnu sliku procesa izranjanja i poniranja (I/P) vodenih masa u području Srednjeg Jadrana, pobliže u širem akvatoriju otočića Jabuke i Blitvenice te na prostoru koji ih povezuje. Osim fizikalnih aspekata, istražit će se kako I/P utječe na biogeokemijske procese i staništa te kako se biološki indikatori očituju u područjima izraženog I/P.Ovo će se postići zajedničkim radom geofizičara – oceanografa i meteorologa – te biologa i kemičara. Istraživat će se meteorološki uvjeti koji pogoduju izranjanju i poniranju. Pomoću satelitskih mjerenja identificirat će se područja I/P u Jadranu. Provest će se dvogodišnja kontinuirana mjerenja temperature, otopljenog kisika i razine mora. Tijekom višednevnih krstarenja, osim klasičnih CTD mjerenja, s visokom prostornom rezolucijom će se mjeriti hidrografska svojstva te morske struje u eufotičkoj zoni. Kvantificirat će se podmorska vegetacija Jabuke, Blitvenice i okolnog područja te dovesti u vezu s abiotičkim čimbenicima, dok će se planktonske zajednice analizirati u sprezi s detaljnim mjerenjima hidrografskih svojstava. Hidrodinamičko numeričko modeliranje će, s osloncem na mjerenja, pomoći da se razumije uloga meteorološkog forsiranja i složene batimetrije kao i ukupna dinamika izranjanja i poniranja.]]></summary_hr><summary_en><![CDATA[Upwelling has significant consequences on marine life because the upward motion transports nutrient-rich deep water towards the surface, and in doing so stimulates primary production and the development of higher levels of the food web. Biological research in the 1980s linked an abundance of plankton, zones of sardine spawning and large catches in the region of Blitvenica Island to upwelling of subsurface water from the Jabuka Pit.The final goal of the MAUD project is to create an integral picture of upwelling and downwelling (U/D) of water masses in the Middle Adriatic, specifically in the wider area of Jabuka and Blitvenica Islands and the connecting region. In addition to the physical aspects, the effect of U/D on biogeochemical processes and habitats as well as the manifestation of biological indicators in U/D areas will be investigated.  This will be accomplished through the joint work of geophysicists – oceanographers and meteorologists – as well as biologists and chemists. Meteorological conditions favourable for upwelling and downwelling will be investigated. Satellite measurements will be used to identify U/D regions in the Adriatic. Two-year continuous temperature, dissolved oxygen and sea level measurements will be performed. During multiday cruises, in addition to classic CTD measurements, high-spatial-resolution measurements of hydrographic properties and sea currents in the euphotic zone will be carried out. Marine vegetation at Jabuka and Blitvenica Islands and the surrounding area will be quantified and connected to abiotic factors, whereas plankton groups will be analysed in connection with detailed measurements of hydrographic parameters. Hydrodynamic numerical modelling, relying on measurements, will help to understand the role of meteorological forcing and complex bathymetry as well as the complete dynamics of upwelling and downwelling.]]></summary_en></project><project>
<id>7649</id><title_hr><![CDATA[ET TIBI DABO: naručitelji i donatori umjetnina u Istri, Hrvatskom primorju i sjevernoj Dalmaciji od 1300. do 1800. godine]]></title_hr><title_en><![CDATA[]]></title_en><user_id>845</user_id><user_firstLast_name>Damir Tulić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-6031</code><acronim><![CDATA[donart]]></acronim><duration>24.09.2018 - 23.09.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Povijest umjetnosti, </scie_field_hr><scie_field_en>Art history, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Filozofski fakultet u Rijeci]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>25243</team_members_id><team_members_names><![CDATA[ Doktorand: Mario Pintarić ]]></team_members_names><keywords_hr><![CDATA[donatori, naručitelji, društv. elite, Istra, Hr. primorje, sjev. Dalmacija, arhitektura, skulptura, slikarstvo, primijenjena umjetnost, 1300. – 1800. ]]></keywords_hr><keywords_en><![CDATA[donors, commissions, social elites, Istria, Croatian Littoral, North Dalmatia, architecture, sculpture, painting, applied arts, 1300 - 1800]]></keywords_en><summary_hr><![CDATA[Cilj projekta je istražiti utjecaj društvenih elita i pojedinaca na širenje umjetničkih oblika, stilova i rješenja. Taj su proces na području Hrvatske što je u žarištu ovog istraživanja, dijelom kreirali i najvažniji predstavnici europskih dvorova, poput habsburških careva, bavarskih vojvoda, venecijanskih duždeva, apostolskih nuncija i kardinala. Uvid u razloge i odlike njihovih narudžbi omogućit će bolje razumijevanje položaja i htijenja lokalnih donatora u europskom kontekstu. Primjenom metode istraživanja pojedinačnih slučajeva, pokušat će se doći do zaključaka, primjenjivih ne samo na područje jadranske Hrvatske, već i na teritorij Mletačke republike, Apeninskog poluotoka i Srednje Europe. U radu na projektu će uz voditeljicu sudjelovati još 12 istraživača, od kojih je 6 iskusnih znanstvenika s brojnim radovima objavljenim u Hrvatskoj i inozemstvu, a čak 6 mlađih istraživača su studenti doktorskih studija. Glavnina rada na projektu sastojat će se od istraživanja na terenu te usavršavanja u hrvatskim i inozemnim bibliotekama i arhivima. Rezultati istraživanja na projektu, čiji se dodir s interdisciplinarnošću ogleda u povezivanju povijesno-umjetničkog i historiografskog istraživanja, kao i istraživanja socijalnih fenomena, bit će od koristi istraživanjima u heraldici, genealogiji, sfragistici, etnologiji, povijesti književnosti, glazbe i mode te povijesti društva i kulture. U okviru projekta organizirat će se dvije znanstvene radionice i dva međunarodna znan. skupa na kojima će uz istraživače na projektu sudjelovati i drugi znanstvenici iz Hrvatske i inozemstva. Sva četiri skupa rezultirat će zbornicima radova opremljenima znanstvenom aparaturom te objavljenima na internetskoj stranici projekta. Jedan od važnih ciljeva projekta je i diseminacija rezultata istraživanja koja će se provoditi kroz javna predavanja istraživača, prisustvo u medijima, ali naročito kroz kraće diseminacijske tekstove koje će istraživači sustavno objavljivati na blog stranici projekta. ]]></summary_hr><summary_en><![CDATA[The project intends to investigate the influence of the social elites and individuals on the propagation of artistic forms, styles and solutions. In the Croatian territory that will be in the focus of this project, such a process was significantly shaped by the most important representatives of the European courts, such as Habsburg emperors, Bavarian Dukes, Venetian doges, Apostolic Nuncios and Cardinals. A better insight into reasons and characteristics of their commissions will generate a better understanding of the situation and aspirations of the local donors in the European context. By applying the “case study” methodology, we will try to reach conclusions, valid not only for the complete Croatian littoral, but also for the territory of the Venetian Republic, the Apennine Peninsula and Central Europe. Apart from the principal investigator, 12 researchers will take part in the project, half of which are experienced scholars with numerous papers published in Croatia and abroad and half of them are concluding their PhD studies. The project will mainly consist in field research and training and research in the Croatian and international libraries and archives. The results of the research, that interconnects art history and historiography, as well as the research of social phenomena, should also prove valuable for the research in heraldry, genealogy, sphragistics, ethnology, history of literature, music, fashion, as well as the cultural history. The project will also comprise two workshops for the participants and two international conferences, all resulting in proceedings that will be published online. One of the most important goals of the project is the dissemination of the research results through its web page and blog (numerous shorter articles by all the researchers), public lectures and the media.]]></summary_en></project><project>
<id>7655</id><title_hr><![CDATA[Qualifying and implementing a user-centric designed and efficient electric vehicle  (Kvalificiranje i implementacija energetski učinkovitog električnog vozila s dizajnom usmjerenim korisniku)]]></title_hr><title_en><![CDATA[]]></title_en><user_id>11149</user_id><user_firstLast_name>Joško Deur</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-5435</code><acronim><![CDATA[]]></acronim><duration>01.10.2018 - 01.10.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, </scie_field_hr><scie_field_en>Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>25393</team_members_id><team_members_names><![CDATA[ Doktorand: Ivan Cvok ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>7657</id><title_hr><![CDATA[Adaptivno i prediktivno upravljanje utičnim hibridnim električnim vozilima]]></title_hr><title_en><![CDATA[Adaptive and Predictive Control of Plug-in Hybrid Electric Vehicles]]></title_en><user_id>11149</user_id><user_firstLast_name>Joško Deur</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-8323</code><acronim><![CDATA[ACHIEVE]]></acronim><duration>15.10.2018 - 14.10.2022</duration><status>Završio</status><financ_value>131.521,67 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, Elektrotehnika, Računarstvo, Tehnologija prometa i transport, </scie_field_hr><scie_field_en>Mechnical engineering, Electrical engineering, Computer sciences, Transport technology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>12618, 12806, 2741, 7616, 23831, 17751, 24047, 23981, 23948, 24126, 23978, </team_members_id><team_members_names><![CDATA[Branimir Škugor, Mihael Cipek, Tonči Carić, Vinko Lešić, Davorin Hrovat, Vanja Ranogajec, Jure  Soldo, Jakov Topić, Filip Maletić, Martina Ravlić, Ivana Mijić, ]]></team_members_names><keywords_hr><![CDATA[Utična hibridna električna vozila, modeliranje, sinteza voznih ciklusa, optimiranje, adaptivno upravljanje, prediktivno upravljanje, strojno učenje]]></keywords_hr><keywords_en><![CDATA[Plug-in hybrid electric vehicles, modelling, synthetic driving cycles, optimisation, adaptive control, predictive control, machine learning]]></keywords_en><summary_hr><![CDATA[Projekt se bavi projektiranjem adaptivnih i prediktivnih strategija upravljanja tokovima energije utičnih hibridnih električnih vozila (PHEV), kao ključne tranzicijske tehnologije prema energetski učinkovitom, čistom, tihom i održivom transportu budućnosti. Projekt je organiziran oko tri međusobno povezane istraživačke teme: (i) sinteza naturalističkih voznih ciklusa bazirana na metodi Markovljevih lanaca uzimajući u obzir promjenljiv nagib ceste i masu vozila; (ii) optimizirana strategija upravljanja tokovima energije PHEV-a koja za cilj ima postizanje minimalne potrošnje goriva te emisija štetnih plinova, dobre voznosti i udobnosti te umjerenog stupnja degradacije baterije, za širok spektar režima rada i voznih uvjeta; te (iii) adaptivne i stohastičke modelsko prediktivne strategije upravljanja zasnovane na estimaciji i predikciji statističkih značajki voznih ciklusa u stvarnom vremenu. Predložena metodologija demonstrira se kroz studiju slučaja vezanu uz gradske autobuse (PHEV naspram konvencionalnog/Diesel autobusa), za koju je projektnom timu na raspolaganju bogati skup snimljenih voznih ciklusa. Iako se istraživanje usredotočuje na PHEV u paralelnoj (P2) konfiguraciji i demonstrira na primjeru gradskih autobusa uključujući aspekte zona s niskim emisijama (LEZ), razvijena metodologija primjenjiva je i na druge tipove električnih vozila (HEV, EREV te BEV), konfiguracije (serijsku i serijsko-paralelnu) i kategorije (npr. osobna vozila i kamioni). Predložene strategije upravljanja sustavno se verificiraju u odnosu na referentno mjerilo postavljeno optimizacijama upravljačkih varijabli, pri čemu se kvantificiraju poboljšanja ostvarena primjenom adaptivnih i prediktivnih mehanizama te procjenjuje transferabilnost na druge konfiguracije PHEV pogona. Kako bi se ostvarili ambiciozni ciljevi istraživanja, projekt okuplja multidisciplinarnu istraživačku skupinu koja uključuje istraživače iz područja strojarstva, elektrotehnike i računarstva, te prometnih znanosti.]]></summary_hr><summary_en><![CDATA[The project deals with design of adaptive and predictive energy management control strategies for plug-in hybrid electric vehicles (PHEV), as a key transition technology towards an energy efficient, clean, quiet and sustainable transport of the future. The project is organised around three mutually interconnected research themes: (i) Markov chain-based synthesis of naturalistic driving cycles taking into account road grade and vehicle mass variability; (ii) optimised PHEV energy management control strategy providing minimal fuel consumption/emissions, favourable drivability and comfort, and modest battery degradation, for a wide range of operating modes and driving conditions; and (iii) adaptive and stochastic model predictive control strategies which account for on-line estimated and predicted statistical features of driving cycles. The proposed methodology is demonstrated through a case study of city buses (PHEV vs. conventional/Diesel bus), for which a rich set of recorded driving cycles is available to the project team. Although the research is focused on PHEVs of parallel (P2) configuration and city bus application including aspects of low-emission zones (LEZ), the developed methodology is applicable to other electric vehicle types (HEV, EREV, and also BEV), configurations (series and series-parallel) and categories (e.g. passenger vehicles and trucks). The proposed control strategies are systematically verified with respect to control trajectory optimisation benchmark provided, while quantifying improvements gained through adaptation and prediction mechanisms, and assessing transferability to other PHEV powertrain configurations. To accomplish the ambitious research goals, the project brings together an multidisciplinary research group including researchers from the areas of mechanical engineering, electrical engineering and computing, and traffic engineering.]]></summary_en></project><project>
<id>7658</id><title_hr><![CDATA[Prilagodba uzgoja bijele ribe klimatskim promjenama]]></title_hr><title_en><![CDATA[Adapting marine finfish aquaculture to a changing climate]]></title_en><user_id>5520</user_id><user_firstLast_name>Tin Klanjscek</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-3150</code><acronim><![CDATA[AqADAPT]]></acronim><duration>05.11.2018 - 04.05.2023</duration><status>Završio</status><financ_value>172.420,20 eur</financ_value><scie_area_hr>Biotehničke znanosti, Prirodne znanosti, Tehničke znanosti, Interdiciplinarne znanosti, </scie_area_hr><scie_area_en>Biotechnical sciences, Natural sciences, Technological sciences, Interdisciplinary scientific area, </scie_area_en><scie_field_hr>Biotehnologija, Matematika, Fizika, Kemija, Biologija, Računarstvo, Poljoprivreda, Prehrambena tehnologija, Interdisciplinarne prirodne znanosti, Interdisciplinarne tehničke znanosti, Interdisciplinarne biotehničke znanosti, </scie_field_hr><scie_field_en>Biotechnology, Mathematics, Physics, Chemistry, Biology, Computer sciences, Agriculture, Food technology, Interdisciplinary natural sciences, Interdisciplinary technological sciences, Interdisciplinary biotechnical sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>20457, 5800, 19037, 5426, 3983, 1377, 20466, 19972, 2551, 5519, 23207, 6027, 25277, 29281, 17593, 865078, 865306, </team_members_id><team_members_names><![CDATA[Lav  Bavčević, Damir Kapetanović, Jakov Žunić, Ana Gavrilovic, Jasmina Obhođaš, Davorin Sudac, Marko Jusup, Mauro Štifanić, Jadranka Pečar Ilić, Sunčana Geček, Ines Haberle, Branimir Hackenberger Kutuzović, Andrija Vinković, Fran Barac, Nina Marn, Marija Purgar Purgar, Božidar Kurtović, ]]></team_members_names><keywords_hr><![CDATA[modeliranje rasta riba, prilagodba agrikulture klimatskim promjenama, sedimenti, vodeni stupac, zdravlje riba, radiokronologija, frakcionacija izotopa]]></keywords_hr><keywords_en><![CDATA[modelling fish growth, adaptation of agriculture to climate change, sediment, water column, fish health, radiochronology, isotope fractionation]]></keywords_en><summary_hr><![CDATA[Uzgoj bijele ribe predstavlja važnu gospodarsku granu u Hrvatskoj sa značajnim potencijalom za rast. Budući da se uzgoj pretežno odvija u priobalnim kavezima ovisnim o uvjetima okoliša, rast i zdravlje riba, a samim time i proizvodnja, podložnisu klimatskim promjenama. Klimatske promjene i njihovi utjecaji postaju sve vidljiviji, te ugrožavaju opstojnost i razvoj akvakulture. Predloženi projekt će provođenjem temeljnih istraživanja prirodnih procesa i primjenom rezultata na biotehnologiju uzgoja riba te uz uspostavu baze znanja, doprinjeti stvaranju prilika za poboljšanje proizvodnje i smanjiti ugroze zbog utjecaja klimatskih promjena. Istraživanje će započeti identifikacijom najznačajnijih fizikalnih i bioloških procesa u akvakulturi povezanih s klimatskim promjenama. U tu svrhu prikupit će se i analizirati dugoročni povijesni trendovi u vodenom stupcu i sedimentu u područjima tipičnim za hrvatskuakvakulturu. Rezultati će se iskoristiti za razvoj modela rasta riba i razumijevanje zdravlja riba i mikrobioloških pokazatelja kao funkcije okolišnih uvjeta. Pomoću razvijenih modela i stečenih znanja predvidjet ćemo učinke najmanje tri scenarijaIPCC klimatskih promjena na proizvodnju i zdravlje riba, koje ćemo analizirati te ćemo za svaki od scenarija specificirati preporuke za prilagodbe proizvodnog procesa. Rezultati će biti objedinjeni u online bazu znanja u obliku koji je dostupan znanstvenicima, proizvođačima u akvakulturi i stvarateljima politika. Projekt, dakle, planira (i) temeljna istraživanja koja rezultiraju novim znanjem, podacima i modelima od interesa za znanstvenike, i (ii) primijenjena istraživanja usmjerena na pripremu akvakulture u Hrvatskoj za promjenu klime. Pokušat će se i uspostaviti suradnja s relevantnim EU projektima u tijeku (npr. ClimeFish) s ciljem postizanja sinergija i priključivanja konzorcija u budućim prijavama na EU projekte.]]></summary_hr><summary_en><![CDATA[Marine finfish aquaculture is an important industry in Croatia with significant growth potential. Since fish are cultured mainly in near-shore cages open to environmental conditions, their growth and well-being, and therefore the aquaculture production, is susceptible to climate change. The effects of the ongoing climate change are becoming increasingly visible, and threaten the viability and development of the aquaculture. AqADAPT will help turn the threats into an opportunity by conducting fundamental research into imminent threats to the aquaculture, and creating a know ledge base for adaptation of the industry. The research will start by focusing on identification of key physical and biological processes in aquaculture affected by climate change. To this end, we will collect and analyze both long-term historical trends, and the seasonal cycles in physical characteristics of the water column and sediments relevant tothe Croatian aquaculture. The results will be used to inform physiologically-based fish growth models, and analysis of threats to fish health and pools of microbiological contamination as functions of environmental conditions. We will use the modelsand knowledge to forecast effects of at least three IPCC climate change scenarios on aquaculture production and fish health. Finally, we will assess the predicted effects, and develop recommendations for adaptation for each of the scenarios. Theresults will be integrated into an on-line know ledge base in a form accessible to scientist, aquaculture producers, and decision-makers. The project therefore plans both (i) fundamental research resulting in new knowledge, data, and models of interest to scientists, and (ii) applied research aimed at preparing aquaculture industry in Croatia for the changing climate. An effort will be made to interact with relevant ongoing EU projects (e.g. ClimeFish), with the goal of achieving synergies and joining the consortium(s) in a future EU funding proposal. ]]></summary_en></project><project>
<id>7659</id><title_hr><![CDATA[Proizvodnja željeza uz rijeku Dravu u antici i srednjem vijeku: stvaranje i transfer znanja, tehnologija i roba]]></title_hr><title_en><![CDATA[]]></title_en><user_id>7810</user_id><user_firstLast_name>Tajana Sekelj Ivančan</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-6767</code><acronim><![CDATA[TransFER]]></acronim><duration>24.10.2018 - 23.10.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Arheologija, </scie_field_hr><scie_field_en>Archeology, </scie_field_en><institution_hr><![CDATA[Institut za arheologiju]]></institution_hr><institution_en><![CDATA[Institute of Archaeology in Zagreb]]></institution_en><team_members_id>25295</team_members_id><team_members_names><![CDATA[ Doktorand: Tena Karavidović ]]></team_members_names><keywords_hr><![CDATA[Proizvodnja željeza, talioničke peći, sirovina, drveni ugljen, Podravlje, socio-kulturološki odnosi ]]></keywords_hr><keywords_en><![CDATA[Production of Iron, Smelting furnaces, Raw Materials, Charcoal, Drava River Valley, Socio-Cultural Relations]]></keywords_en><summary_hr><![CDATA[Cilj projekta je proširiti spoznaje o primarnoj obradi željeza u nizinskom području rijeke Drave te definirati značenje proizvodnje željeza u kontekstu socio-kulturoloških odnosa u različitim povijesnim razdobljima (antika i srednji vijek). Projektni zadaci usmjereni su na važna pitanja: 1. definirati podrijetlo željezne rude i potrebnih resursa (glina, voda, drvo); 2. definirati tehnologiju obrade željezne rude kroz povijesna razdoblja;3. definirati utjecaj proizvodnje željeza u kontekstu socio-kuturoloških odnosa. Važan naglasak u svim fazama projekta stavljen je na interdisciplinarna istraživanja. Provest će se preliminarna istraživanja nizinskog prostora uz rijeku Dravu primjenjujući arheološke, geološke i geofizičke metode. Na temelju dobivenih rezultata poduzet će se uzorkovanje tla radi definiranja izvora sirovine, kao i ciljana arheološka istraživanja na dvije odabrane pozicije. Fokus istraživanja usmjerit će se prema promjenama u tehnologiji obrade željeza kroz primjenu različitih tipova peći u različitim razdobljima. Na uzorcima će se provest arheometalurške i metalografske analize s ciljem dobivanja podataka o tehnologiji prerade rude u određenom razdoblju, ali i njena podrijetla, odnosno veze s geološkom podlogom. Analizom vrste drva, posredno će se dobiti slika krajolika (šume) dravske nizine. Očekuje se da će projekt pružiti nove podatke za razumijevanje promjena u tehnologiji obrade željezne rude koje su se dogodile, primarno, unutar istog prostora kroz vrijeme.Sinergijski efekt interdisciplinarnog istraživačkog tima i sveobuhvatna metodologija omogućit će, kroz praćenje gotovih željeznih proizvoda u svakodnevnici, razumijevanje socioloških i kulturoloških odnosa u nizinskom dravskom prostoru, ali i u širem, srednjeeuropskom kontekstu.Novi podaci bit će prikazani pomoću GIS platforme te time u odgovarajućoj formi javno dostupni za razmatranja prostornih korelacija unutar samih metalurških kompleksa, ali i u odnosu na šire područje.]]></summary_hr><summary_en><![CDATA[The aim of the project is to expand knowledge about the primary processing of iron in the lowland area of the Drava River and to define the significance of iron production in the context of socio-cultural relations in the context of ancient and medieval societies. The project focuses on several important aspects: 1. To define the source of iron ore and necessary resources (clay, water, wood); 2. To define the technology of processing iron ore throughout historical periods; 3. To define the impact of iron production in the context of sociocultural relations. An important emphasis is placed on interdisciplinary research in all phases of the project. Preliminary investigation of the lowlands will be performed using archaeological, geological, and geophysical methods. Soil sampling will take place on the basis of obtained results, as will targeted archaeological excavation at two selected sites. Research will be focused on changes in the technology of iron processing through the used of various kinds of furnaces in different periods. Archaeometallic and metallurgical analyses will be performed on samples to obtain data about the processing of ore in a given period, but also its origin in terms of the geology. Through charcoal analysis, the wood types will indirectly offer information about the then landscape (forests). The project is expected to offer new data for understanding changes in the technology of processing iron ore that occurred within the same area throughout time. The synergistic effect of the interdisciplinary research and the comprehensive methodology will enable, through analysis of the finished everyday iron products, comprehension of social and cultural relations in the lowland Drava valley, but also in a wider, central European context. New data will be presented in a GIS platform, enabling public access to consideration of spatial correlations within the metallurgical complex, but also referring to the broader region.]]></summary_en></project><project>
<id>7660</id><title_hr><![CDATA[Filostratigrafija nastanka i gubitka gena]]></title_hr><title_en><![CDATA[]]></title_en><user_id>598</user_id><user_firstLast_name>Tomislav Domazet-Lošo</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-6673</code><acronim><![CDATA[PhyLoss]]></acronim><duration>04.10.2018 - 01.01.2023</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>25280</team_members_id><team_members_names><![CDATA[ Doktorand: Nina Čorak ]]></team_members_names><keywords_hr><![CDATA[filostratigrafija, evolucijska genomika, nastanak gena, gubitak gena, genske obitelji]]></keywords_hr><keywords_en><![CDATA[phylostratigraphy, evolutionary genomics, gene gain, gene loss, gene families]]></keywords_en><summary_hr><![CDATA[Evolucijski životni ciklus gena u genomu pokretan je procesom rađanja i umiranja gena. Mada ovaj mehanizam direktno utječe na sadržaj genoma uzrokujući dobitak i gubitak gena njegova dinamika kroz filogeniju eukariota još je nerazjašnjena. Nastanak i gubitak cijelih genskih obitelji je dodatna razina evolucijskog protoka u genomima koja je česta ali često ignorirana pojava. Za praćenje nastanka i gubitka genskih obitelji moguće je u principu koristiti filostratigrafski pristup. U ovom projektu, predlažemo stvaranje sveobuhvatne i usklađene procjene nastanka i gubitka genskih obitelji kroz filogeniju eukariota koristeći stotine eukariostkih genoma unutar filostratigrafskog okvira. Ovo znanje omogućit će nam procjenu odnosa između stopa nastanka i gubitka genskih obitelji kroz evolucijsko vrijeme i rekonstrukciju sastava genskih obitelji u predačkim genomima. Kako bi ostvarili ove ciljeve razvit ćemo nove algoritme i implementirati nove strategije računanja unutar filostratigrafskog okvira te ćemo ova rješenja učiniti javno dostupna kroz web aplikaciju.  Kada katalog nastanka i gubitka gena bude gotov cilj nam je povezati profile nastanka i nestanka gena s evolucijom fenotipova. Osim evolucijske biologije, naša kolekcija nastanka i gubitka genskih obitelji biti će vrijedan izvor informacija za različita područja uključujući komparativnu genomiku, razvojnu biologiju i translacijsku medicinu. Na primjer, biti će moguće pronaći organizme koji su ‘evolucijski nul-mutanti’ za gene povezane s patološkim promjenama kod čovjeka kao i nove gene povezane s bolestima.Osim direktne koristi od publikacija u vodećim časopisima i znanstvenih suradnji uvjereni smo da će ovaj projekt imati značajan utjecaj na trening mladih znanstvenika koje namjeravamo zaposliti na projektu i osposobiti ih za vođenje istraživanja na presjeku evolucijske i računalne biologije.]]></summary_hr><summary_en><![CDATA[The evolutionary life cycle of genes is powered by the process of gene birth and death. Although this mechanism directly impacts the genome content by generating the gain and loss of genes its dynamics within the phylogeny of eukaryotes is still unclear. The gain and loss of entire gene families is another level of the evolutionary turnover in genomes which is rather frequent but often ignored phenomena. To trace gene family gain and loss one can in principle use phylostratigraphic approach.In this project, we propose to get a comprehensive and synchronized estimate of gene family gain and loss across phylogeny of eukaryotes using hundreds of eukaryotic genomes within the phylostratigraphic framework. This knowledge will allow us to estimate rates of gene family gain and loss relate over evolutionary time, and to reconstruct the ancestral genomes. To achieve these goals we will develop novel algorithms and implement a new computational strategy within the phylostratigraphic framework which will be available as a publicly accessible web resource.   Once the catalogue of gene family gain and loss is complete, we aim to link the gene-and-loss patterns to the evolution of phenotypes. Beside evolutionary biology, our gene gain and loss collection that cover wide range of eukaryotes will provide valuable information for many fields including comparative genomics, developmental biology and translational medicine. For instance it will allow us to look for the organisms that are ‘evolutionary knockouts’ for genes related to human pathologies and to find new candidate genes for diseases.    Beyond the immediate benefits of high impact scientific publications and scientific collaboration we believe that this project will have a profound impact in training young experts that we aim to hire on the project and enabling them to lead the research at the interface between evolutionary and computational biology.]]></summary_en></project><project>
<id>7666</id><title_hr><![CDATA[Uloga heterozigotnosti gena za ribosomski protein S6 u zloćudnoj preoprazbi stanica]]></title_hr><title_en><![CDATA[]]></title_en><user_id>7705</user_id><user_firstLast_name>Siniša Volarević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-5710</code><acronim><![CDATA[ONCO-RIB]]></acronim><duration>17.09.2018 - 16.09.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Medicine]]></institution_en><team_members_id>25212</team_members_id><team_members_names><![CDATA[ Doktorand: Ylenia Prodan ]]></team_members_names><keywords_hr><![CDATA[zloćudni tumori, ribosomski protein S6, supresor tumora p53, sinteza ribosoma, jezgrica]]></keywords_hr><keywords_en><![CDATA[cancer, ribosomal protien S6, p53 tumor suppressor, ribosome biogenesis, nucleolus]]></keywords_en><summary_hr><![CDATA[Istraživanja tijekom proteklih desetak godina dokazala su da heterozigotne mutacije specifičnih ribosomskih proteina (RP) uzrokuju patološke promjene u životinjskim pokusnim modelima i nekoliko bolesti u ljudi, uključujući 5q- mijelodisplastični sindrom, anemiju Diamond-Blackfan i brojne vrste zloćudnih tumora. Međutim, molekularni mehanizmi putem kojih heterozigotne mutacije RPs uzrokuju bolesti najvećim dijelom su nepoznati. Proizveli smo genetički modificiranog miša u kojemu se gen za RpS6 može izrezati pomoću rekombinaze Cre. Upotrebom toga životinjskog modela dokazano je da heterozigotnost za RpS6 u stanicama koštane srži uzrokuje patološke promjene koje su slične premalignom sindromu 5q- u ljudi. U pripremi za ovaj projekt HRZZ dokazali smo da heterozigotnost za RpS6 u fibroblastima iz embrija miša (MEF) značajno doprinosi njihovoj zloćudnoj preobrazbi. Temeljem tih rezultata postavljamo hipotezu da heterozigotnost za RpS6 uzrokuje molekularne promjene koje potiču zloćudnu preobrazbu normalnih stanica. Predlažemo sljedeće specifične ciljeve istraživanja koji će omogućiti testiranje te hipoteze:1. Proizvesti MEF-ove u kojima se može uvjetno odstraniti jedan alel gena za RpS6 i gen p53 2. Testirati onkogeni potencijal MEF-ova heterozigotnih za RpS6 3. Odrediti učinak heterozigotnosti za RpS6 gen i gubitka gena p53 na morfološka obilježja jezgrice i njene funkcije, stabilnost genoma, strukturu kromatina i globalnu regulaciju izražaja gena.4. Identificirati mRNA čija je translacija na ribosomima poremećena.Ovaj prijedlog projekta pravovremen je i inovativan. Predloženo istraživanje razjasnit će zagonetku kako sniženi izražaj RP, ključnih sastavnica staničnih strojeva koji omogućuju rast stanice, uzrokuju zloćudne tumore. Osim toga, projekt će unaprijediti istraživački kapacitet, obrazovanje mladih znanstvenika i podići razinu kvalitete istraživanja u Hrvatskoj putem suradnje s vrhunskim svjetskim istraživačima.]]></summary_hr><summary_en><![CDATA[An abundance of evidence from animal models and human disease has shown that inherited and acquired heterozygous mutations of a number of ribosomal proteins can lead to cancer development as well as a variety of other diseases. However, the underlying molecular mechanisms are still largely unknown. We have previously generated a mouse model in which one allele of the RpS6 gene can be conditionally deleted. By employing this model it was shown that RpS6 heterozygosity in bone marrow recapitulates key features of a premalignant condition in humans, the 5q- syndrome. Our preliminary results have shown that RpS6 heterozygous mouse embryonic fibroblasts (MEFs) in the absence of p53 show much greater tumorigenicity than p53 null MEFs, further supporting the view that RpS6 heterozygosity is an oncogenic event. Thus, we hypothesize that RpS6 heterozygosity may lead to molecular alterations that could facilitate malignant transformation. In order to test this hypothesis, we propose the following specific aims:1. Generate conditional MEFs for inducible deletion of one RpS6 allele alone or in combination with p53 gene2. Assess tumorigenic potential of RpS6 heterozygosity3. Determine the impact of RpS6 heterozygosity and p53 loss on nucleolar structure and function, maintenance of genome stability, chromatin structure and global regulation of gene transcription.4. Characterize the mRNA translation landscape of RpS6 heterozygous MEFs.This is innovative and timely proposal. Our studies will elucidate a long standing conundrum, how hypomorphic mutations in RP genes, essential components of the cell’s growth machinery can lead to cancer. The project should positively impact the research capacity, education and science in Croatia via scientific cooperation with world-renowned scientists abroad.]]></summary_en></project><project>
<id>7670</id><title_hr><![CDATA[Kvantno-kemijski dizajn, priprava i biološka svojstva organometalnih derivata nukleobaza]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5594</user_id><user_firstLast_name>Valerije Vrček</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-5277</code><acronim><![CDATA[OrDeN]]></acronim><duration>23.07.2018 - 22.10.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Farmaceutsko-biokemijski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Pharmacy and Biochemistry]]></institution_en><team_members_id>25235</team_members_id><team_members_names><![CDATA[ Doktorand: Mateja Toma ]]></team_members_names><keywords_hr><![CDATA[metalocen, nukleozid, bioaktivnost, elektrokemija, DFT računi]]></keywords_hr><keywords_en><![CDATA[metallocene, nucleoside, bioactivity, electrochemistry, DFT calculations]]></keywords_en><summary_hr><![CDATA[Organometalni derivati nukleobaza (OrDeN-i) nova su generacija konjugata u kojima su povezani metaloceni s temeljnim supstrukturnim elementima nasljeđivanja. Zbog elektrofornih i bioaktivnih svojstava OrDeN-i nalaze primjenu u (bio)analitičkoj i medicinskoj kemiji. Priprava OrDeN-a se temelji na sintetskoj kopulaciji organometalnog dijela i heterocikličke baze koristeći razne vrste mostova. Izbor fragmenata uglavnom je vođen pristupom što veće raznolikosti strukturnih motiva. U okviru ovog projekta strukturne modifikacije OrDeN-a bit će usmjerene prema pripravi derivata s izraženim elektrokemijskim i biološkim svojstvima. Eksperimentalnom dijelu istraživanja prethodit će opsežni kvantno-kemijski izračuni. Metodama teorije funkcionala gustoće (DFT metode) moguće je predvidjeti kemijska svojstva OrDeN-a, poput reaktivnosti/stabilnosti, redukcijskog potencijala, supstitucijskih i solvatacijskih efekata. Ti parametri mogu poslužiti za dizajn OrDeN-a s poboljšanim biološkim svojstvima. Koristit će se one DFT metode koje se tijekom sustavne procjene teorijskih modela (benchmarking) pokažu optimalnim u opisu bioorganometalnih modela za koje postoje eksperimentalni podaci. Novi strukturni elementi OrDeN-a uključuju funkcionalni most, niz homoanularnih supstituenata, odabrane parove metalocena  i nukleobaza, te bis-adukte. Novi most (linker) koji povezuje dva osnovna dijela OrDeN-a je karbonilna skupina i njezini reducirani oblici, hidroksilna i metilenska skupina. Elektronska komunikacija metalocena i nukleobaze ovisit će, dakle, o oksidacijskom stanju i hibridizaciji funkcionalnog mosta, a podešavat će se uvođenjem odabranih supstituenata na ciklopentadienilni prsten. Usporedba kvantno-kemijskih procjena s elektrokemijskim/ biološkim profilima pripravljenih modela upotrijebit će se u (re)dizajnu parova metalocena i nukleobaza, te ciljanih bis-adukata OrDeN-a.]]></summary_hr><summary_en><![CDATA[Organometallic nucleobase derivatives (OrDeNs) correspond to a new generation of conjugates in which metallocenes are linked to the basic structural elements of heredity. Due to their electrophoric and bioactive properties, OrDeNs are of use in (bio)analytical and medicinal chemistry. The preparation of OrDeNs is based on the copulation reaction between the organometallic part with a heterocyclic base, by using different linkers. The choice of fragments usually follows the target of the ever-growing diversity of structural motifs. In this project all modifications of OrDeNs structures will be directed toward derivatives with marked electrochemical and biological properties. An extensive quantum chemical study will precede the experimental part of the research. By using the density functional theory methods (DFT methods) the chemical properties of OrDeNs, such as stability/reactivity, reduction potential, substituent and solvation effects, can be predicted. These parameters can assist in designing OrDeNs with enhanced bioactivity. A benchmark study in evaluating DFT methods will be performed. DFT methods which are superior in the description of biorganometallic models (for which experimental data are known) will be used to study OrDeNs. New structural elements in OrDeNs include the functional linker, a series of homoannular substituents, selected metallocene-nucleobase pairs, and bis-adducts. A new linker type, which connects the two constitutional parts in OrDeNs, is a carbonyl group and its reduced forms, hydroxyl and methylene groups. The electron communication between metallocene and nucleobase depends, therefore, on the oxidation state and hybridization of the functional linker, and can be tuned by using selected substituents at the cyclopentadienyl ring. The interplay between quantum chemical estimates and electrochemical/biological profiles for model compounds will advance the (re)design of new metallocenes-nucleobase pairs and bis-adducts of OrDeNs.]]></summary_en></project><project>
<id>7672</id><title_hr><![CDATA[Identifikacija interaktoma paralognih proteina SSB u višestaničnom prokariotu, Streptomyces coelicolor ]]></title_hr><title_en><![CDATA[Identifying interactome of paralogous SSB proteins in a multicellular prokaryote, Streptomyces coelicolor ]]></title_en><user_id>5240</user_id><user_firstLast_name>Ksenija Zahradka</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-1754</code><acronim><![CDATA[id_ROBUST]]></acronim><duration>15.10.2018 - 14.07.2023</duration><status>Završio</status><financ_value>131.992,83 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>5910, 5912, 6405, 24074, 23953, 28732, 865445, 23612, </team_members_id><team_members_names><![CDATA[Tina  Paradžik, Želimira Filić, Boris Macek, Dagmara  Jakimowicz, Paul Hoskisson, Goran Pipalović, Mohammad Sarim Khan, Mirsada Ćehić, ]]></team_members_names><keywords_hr><![CDATA[Interaktom, paralozi proteina SSB, Streptomyces, DNA metabolizam, sinteza antibiotika]]></keywords_hr><keywords_en><![CDATA[Interactome, paralogous SSB, Streptomyces, DNA metabolism, antibiotic synthesis ]]></keywords_en><summary_hr><![CDATA[Streptomiceti su bakterije poznate po proizvodnji važnih antibiotika te složenom životnom ciklusu. U svim domenama života, proteini SSB koji vežu jednolančanu DNA imaju ključnu ulogu u replikaciji, popravku i rekombinaciji DNA. Različite bakterijske vrste imaju više paraloga SSB-a, no njihova biološka uloga je slabo istražena. Naši rezultati su pokazali kako su paralozi SSB bakterije S. coelicolor evoluirali te poprimili različite stanične funkcije. SsbA je nužan za preživljavanje, dok SsbB ima ključnu ulogu u segregaciji kromosoma tijekom sporulacije. Nedavno smo uočili da delecija gena ssbB kod određenog mutanta S. coelicolor pojačava proizvodnju antibiotika. U svrhu boljeg razumijevanja bioloških funkcija proteina SSB, cilj ovog projekta je identifikacija ineraktoma paralognih proteina SSB, analiza domene/motiva odgovornih za interakcije, te rasvjetljavanje uloge disulfidnih mostova za funkciju proteina SsbB. Najinteresantniji partneri SSB-a koji će se identificirani B2H i TAP tehnologijama,  dodatno će se analizirati raznim in vivo i in vitro tehnikama. Konstruirat ćemo, te morfološki i fenotipski okarakterizirati jednostruke i dvostruke mutante streptomiceta kojima nedostaje gen za sintezu interaktanta i gen ssbB. Kolokalizacija SSB-a i odabranih partnera ispitat će se fluorescencijskom mikroskopijom. Mehanizam vezanja proteina SSB i partnera istražit će se primjenom raznovrsnih metoda za određivanje afiniteta vezanja, poput polukvantitativnih metoda (EMSA), spektroskopskih tehnika (CD, fluorescencija, MST) i kalorimetrijskih tehnika (npr. ITC). Komparativnom proteomskom analizom istražit će se vremenska dinamika sinteze SsbB-a i njegovih partnera tijekom rane log faze i faze programirane stanične smrti kod S. coelicolor i S. rimosus s povećanom sintezom antibiotika. Pretpostavljaući da je većina partnera SsbB-a sačuvana kod streptomiceta, predložena analiza mogla bi otkriti i vremenski-ovisne SSB interakcije, potencijalno važne za sintezu antibiotika.  ]]></summary_hr><summary_en><![CDATA[Streptomycetes are best known as producers of clinically important antibiotics and for their complex life cycle. Single-strand DNA-binding (SSB) proteins have a key role in DNA replication, repair and recombination in all domains of life. Various bacteria possess paralogous SSBs, but their biological role is poorly understood. We reported that two S. coelicolor SSBs have adopted different cellular functions through evolution. While SsbA is indispensable for survival, SsbB has a key role in chromosome segregation during spore formation. Recently, we found that a specific mutant with deleted ssbB increases antibiotic production. To get a better insight into biological functions of paralogous SSB proteins, this project aims to identify SSB-interactomes, to analyse their binding domains and to elucidate the importance of disulphide bridges for SsbB functionality. Once identified by B2H system or TAP technology, the most promising interactants will be analysed by applying in vivo and in vitro techniques. Genetic constructs carrying mutations in gene encoding protein partner (if not essential) or double mutants with ssbB gene will be examined phenotypically and morphologically. The co-localization of selected SSB partners will be examined by fluorescence microscopy. To obtain information on the binding mechanisms of SSB-protein interactions, the affinity of the interacting proteins will be analysed by several approaches, such as semi-quantitative assays (EMSA), spectroscopic techniques (CD, fluorescence, MST), and calorimetric techniques like ITC. Comparative proteomic analysis will be applied to examine temporal synthesis of SsbB and its protein partners during early log and programmed cell death stage of growth in S. coelicolor and S. rimosus with elevated antibiotic production. Expecting that most of the SSB partners are conserved in Streptomyces spp., proposed analyses could uncover time-specific interaction, potentially important for antibiotic production. ]]></summary_en></project><project>
<id>7674</id><title_hr><![CDATA[Nova generacija poluvodičkih elemenata i integriranih sklopova za eru Interneta stvari]]></title_hr><title_en><![CDATA[Next-generation Semiconductor Devices and Integrated Circuits for the Internet-of-Things Era]]></title_en><user_id>6955</user_id><user_firstLast_name>Tomislav Suligoj</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-5296</code><acronim><![CDATA[NexGenSemi]]></acronim><duration>12.10.2018 - 11.03.2023</duration><status>Završio</status><financ_value>198.102,06 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, Interdisciplinarne tehničke znanosti, </scie_field_hr><scie_field_en>Electrical engineering, Interdisciplinary technological sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>7054, 6083, 6081, 24097, 7148, 6852, 28937, 861727, 22510, 865117, </team_members_id><team_members_names><![CDATA[Mirko Poljak, Tihomir Knežević, Josip Žilak, Željko Osrečki, Dubravko Babic, Marko Koričić, Ivan Berdalović, Filip Bogdanović, Lovro Marković, Borna Požar, ]]></team_members_names><keywords_hr><![CDATA[Internet stvari, bipolarni tranzistor s horizontalnim tokom struje, pouzdanost, poluvodički fotodetektor, galij-nitrid, simulacije poluvodiča]]></keywords_hr><keywords_en><![CDATA[Internet of Things, Horizontal Current Bipolar Transistor, reliability, semiconductor photodetectors, gallium-nitride, semiconductor simulations]]></keywords_en><summary_hr><![CDATA[Cilj ovoga projekta je istražiti nove poluvodičke elemente i sklopove pogodne za primjenu na različitim nivoima Interneta stvari (eng. Internet-of-Things – IoT), od senzorskih čvorova, preo komunikacijskih sklopova, do elemenata za mrežnu infrastrukturu. Elektronički elementi i sklopovi za tako različite dijelove IoT sustava bit će istraženi u 3 područja: (i) Pouzdanost i pojačala snage u tehnologiji tranzistora sa horizontalnim tokom struje (HCBT), (ii) Projektiranje, karakterizacija i modeliranje blisko infracrvenih, vidljivih i UV fotodetektorskih prednjih krajeva, i (iii) Modeliranje i primjene GaN HEMT-ova.Doherty pojačalo snage i pojačalo za praćenje envelope kao primjeri visokoefikasnih RF pojačala snage za modulacije s velikim omjerom maksimalne i prosječne snage projektirat će se u HCBT tehnologiji koja ima nisku cijenu proizvodnje, a vrlo visoke performanse. To će biti prva RF pojačala snage s HCBT-ovima čime će se pokazati prikladnost tehnologije za sklopove s velikim signalom. Dodatno će se proučavati i pouzdanost HCBT elemenata s obzirom na pobudu jakim RF signalom i zračenjima.Uz proširenje našeg jedinstvenog električkog modela PureB materijala na siliciju za UV detektore, predloženi projekt bit će usmjeren i na visoko-osjetljive, blisko infra-crvene detektore implementirane u čistom galiju i PureB (PureGaB) na germaniju (Ge) nanesenom na Si supstrat, kao i na projektiranje detektora jednog fotona i njegove sklopove za potiskivanje proboja.Modeliranje GaN HEMT-a bit će istraženo pomoću fizikalno-baziranih modela. Transport elektrona u kanalu HEMT-a bit će modeliran samo-konzistentnim simulacijama mehanizama raspršenja, sa korijenima u kvantnoj mehanici, koji će uzeti u obzir kvantno ograničenje, strukturu energetskih pojaseva i sve relevantne mehanizme raspršenja.S obzirom na dosadašnja postignuća naše grupe, mogu se očekivati publikacije u vodećim znanstvenim časopisima i konferencijama kao i prijave patenata.]]></summary_hr><summary_en><![CDATA[The aim of this project is to conduct a research on novel semiconductor devices and circuits suitable for the Internet-of-Things (IoT) applications at various levels, to cover sensor nodes, communication circuits and devices for network infrastructure. Electron devices and circuits for such different parts of IoT systems will be researched in 3 areas: (i) Device reliability and power amplifiers (PAs) in Horizontal Current Bipolar Transistor (HCBT) technology, (ii) Design, characterization and modeling of near-infrared, visible and UV photodetector front-ends, and (iii) Modeling and applications of GaN HEMTs.The Doherty and Envelope tracking PAs with their high-efficiencies for high peak-to-average-power-ratio modulations will be designed in low-cost, high-performance HCBT technology. These will be the first RF power amplifiers with HCBTs demonstrating the suitability of HCBT technology for large-signal RF applications. Additionally, the reliability of HCBT devices will be tested against high RF power stress and radiation stresses.Besides extending our unique electrical model of PureB-on-Silicon material for UV detectors, the focus in the proposed project will also be on high-sensitivity, near-infra-red (NIR) detectors implemented in pure gallium and PureB (PureGaB) on germanium (Ge) grown on Si substrate together with the design of single photon avalanche detectors (SPADs) and their quenching circuits.The modeling of GaN high electron mobility transistor (HEMT) will be researched by physics-based models. The transport of electrons in HEMT channel will be assessed by self-consistent carrier scattering simulations, rooted in quantum mechanics that will take into account quantum confinement, bandstructure effects and all relevant scattering mechanisms.Based on a track record of the group, the publications in the top journals and conferences in the field and patent applications can be expected in this project.]]></summary_en></project><project>
<id>7677</id><title_hr><![CDATA[Modeliranje okolišnih aspekata napredne obrade voda za razgradnju prioritetnih onečišćivala]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1122</user_id><user_firstLast_name>Ana Lončarić Božić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-1728</code><acronim><![CDATA[MEAoWT]]></acronim><duration>13.07.2018 - 12.07.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Kemijsko inženjerstvo, </scie_field_hr><scie_field_en>Chemical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet kemijskog inženjerstva i tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Chemical Engineering and Technology]]></institution_en><team_members_id>25242</team_members_id><team_members_names><![CDATA[ Doktorand: Antonija Tomić ]]></team_members_names><keywords_hr><![CDATA[prioritetna onečišćivala, napredni procesi obrade voda, okolišni aspekti, mehanističko modeliranje, molekulsko modeliranje]]></keywords_hr><keywords_en><![CDATA[priority pollutants, advanced water treatment, environmental aspects, mechanistic modeling, molecular modeling]]></keywords_en><summary_hr><![CDATA[Voda je ključni resurs za čovječanstvo koji stvara i održava ekonomski rast i prosperitet. Europska Okvirna direktiva o vodama postavlja strategiju o onečišćenju voda u EU i uključuje listu prioritetnih tvari koje predstavljaju značajan rizik za vodni okoliš. Konvencionalne tehnologije obrade voda većinom se temelje na fizikalnim i biološkim procesima koji nisu adekvatni za učinkovito uklanjanje prioritetnih tvari. Stoga, razvoj održivih tehnologija obrade voda zahtijeva primjenu naprednih kemijskih procesa. Iako je konverzija onečišćivala glavni kriterij u ocjeni učinkovitosti obrade, okolišni aspekti primijenjene tehnologije odnose se na ukupnu kvalitetu obrađene vode koja se može izraziti putem sumarnih ekoloških pokazatelja kvalitete voda. Glavni cilj projekta MEAoWT je predložiti održivu tehnologiju za obradu voda koje sadrže prioritetna onečišćivala (farmaceutike i pesticide) te pružiti metodologiju za predviđanje okolišnih aspekata primijenjene tehnologije koja će služiti kao alat za procjenu kvalitete voda i kontrolu onečišćenja. U tu svrhu, za razgradnju odabranih prioritetnih onečišćivala u vodi primijenit će se UV/H2O2, UV/S2O82- i ferat (VI) oksidacijski procesi. Eksperimentalni će se podaci koristiti za izradu modela kombinirajući statističke, matematičke, mehanističke i strukturne pristupe, koristeći napredne računalne alate. Strukturne karakteristike onečišćivala u vodi, mehanizmi i kinetika razgradnje kao i radni parametri procesa obrade korelirat će se s kvalitetom obrađene vode izražene preko sumarnih ekoloških pokazatelja. Predložit će se metodologija za predviđanje, procjenu i kontrolu okolišnih aspekata tehnologije za obradu voda.]]></summary_hr><summary_en><![CDATA[Water is a crucial resource for humanity, generating and sustaining economic growth and prosperity. The European Water Framework Directive lays the EU water pollution strategy, and includes a list of priority substances which represent a significant risk to aquatic environment. The conventional water treatment technologies rely mostly on physical and biological processes which seem to be inadequate for effective removal of priority substances. Therefore, development of sustainable water treatment technologies requires the application of advanced chemical processes. Although the conversion of pollutants is main criterion in evaluation of treatment efficiency, the environmental aspects of applied technology are related to the overall quality of treated water which can be expressed in the terms of ecological sum-parameters. The main goal of MEAoWT project is to propose sustainable technology for the treatment of water containing priority pollutants (pharmaceuticals and pesticides) and to provide the methodology for the prediction of environmental aspects of applied technology, as a powerful tool for water quality assessment and pollution control. For that purpose UV/H2O2, UV/S2O82- and ferrate(VI) oxidation processes will be applied for the degradation of selected priority pollutants in water. Experimental data will be used for development of models combining statistical, mathematical, mechanistic and structural approaches using advanced computational tools. Structural characteristics of water pollutants, degradation mechanisms and kinetics as well as operating parameters of treatment processes will be correlated with the quality of treated water in terms of ecological sum-parameters. The methodology for prediction, assessment and control of the environmental aspects of water treatment technology will be proposed.]]></summary_en></project><project>
<id>7679</id><title_hr><![CDATA[Eugen Savojski (1663.-1736.) i gradovi-tvrđave jugoistočne granice Habsburške Monarhije]]></title_hr><title_en><![CDATA[Eugene of Savoy (1663-1736) and Fortress-Towns on the South-Eastern Border of the Hapsburg Monarchy]]></title_en><user_id>23359</user_id><user_firstLast_name>Katarina Horvat Levaj</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-3844</code><acronim><![CDATA[EUGEN]]></acronim><duration>09.11.2018 - 08.05.2023</duration><status>Završio</status><financ_value>76.626,19 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Povijest umjetnosti, </scie_field_hr><scie_field_en>Art history, </scie_field_en><institution_hr><![CDATA[Institut za povijest umjetnosti]]></institution_hr><institution_en><![CDATA[Institute of Art History, Zagreb]]></institution_en><team_members_id>2693, 3987, 23376, 20064, 23392, 1226, 19261, 24105, 6365, 861740, </team_members_id><team_members_names><![CDATA[Andrej Žmegač, Ratko Vučetić, Margareta  Turkalj Podmanicki, Petar Puhmajer, Vlasta Zajec, Milan Pelc, Radoslav Tomić, Zlatko Uzelac, Ivana Haničar Buljan, Iva Vidović, ]]></team_members_names><keywords_hr><![CDATA[Eugen Savojski, Habsbruška Monarhija, Hrvatska, gradovi-tvrđave, arhitektura, barok]]></keywords_hr><keywords_en><![CDATA[Eugene of Savoy, Hapsburg Monarchy, Croatia, Fortress-Towns, Architecture, Baroque]]></keywords_en><summary_hr><![CDATA[Osloboditelj istočnih dijelova Habsburške Monarhije od Osmanlija, princ Eugen Savojski (1663.–1736.), uz svoju briljantnu vojnu karijeru, istaknuo se i kao inicijator važnih urbanističkih i arhitektonskih zahvata. S jedne strane, njegova se graditeljska djelatnost odnosi na podizanje vlastitih rezidencija u samoj prijestolnici i različitim dijelovima Monarhije. Drugi dio graditeljske aktivnosti, koji je princ vodio kao predsjednik Dvorskog ratnog vijeća, odnosi se na gradove-tvrđave novoformirane granice prema Osmanskom Carstvu. Izgrađeni s upućenošću genijalnog stratega, oni ne znače samo primjenu najmodernijih bastionskih konstrukcija, već sadrže barokne ambijente visoke urbanističke i arhitektonske kvalitete. Strateški položaj današnje istočne Hrvatske u kontekstu nekadašnje austrijsko-turske granice rezultirao je činjenicom da se neki od najmarkantnijih utvrđenih gradova nalaze upravo na hrvatskom teritoriju – Osijek, Slavonski Brod, Stara Gradiška, Orlica – a s njima nedjeljivu cjelinu čini Petrovaradin. Iako formiranje većine navedenih gradova-tvrđava počinje prije Eugenove ere, i nastavlja se nakon njega, upravo im princ od Savoje daje ključni pečat. Angažiranjem vrhunskih vojnih inženjera, pogranične tvrđave po svojim fortifikacijskim sustavima mogu parirati projektima najpoznatijeg europskog graditelja utvrda – Vaubana (1633.–1707.). Istodobno, uključivanjem vodećih državnih arhitekata u projektiranje glavnih javnih i sakralnih zdanja unutar fortifikacijskih prstenova, hrvatska je arhitektura upravo ovdje obogaćena nekim antologijskim primjerima baroka. Budući da navedena tematika u nacionalnim okvirima još nije do kraja istražena, a međunarodnoj je znanstvenoj javnosti gotovo potpuno nepoznata, cilj je ovog projekta istražiti urbanizam i arhitekturu Osijeka, Slavonskog Broda, Stare Gradiške i Petrovaradina, te ih valorizirati u kontekstu drugih utvrda i rezidencija Eugena Savojskog (na području Austrije, Češke, Mađarske, Rumunjske i Srbije).]]></summary_hr><summary_en><![CDATA[The liberator of the eastern parts of the Hapsburg Monarchy from the Ottoman Turks, Prince Eugene of Savoy (1663–1736), in addition to his brilliant military career, was also initiator of important town-planning and architectural undertakings. One the one hand, his building activities concerned the construction his own residences in the capital city and various parts of the Monarchy. The second segment of his building activities, which the Prince headed as President of the Imperial War Council, concerned fortress-towns along the new boundary with the Ottoman Empire. They were built based on the knowledge of a strategic genius, they were not just the application of the most modern bastion structures but also contain Baroque ambiences of high urbanistic and architectural quality.    The strategic position of today’s eastern Croatian in the context of the former Austrian-Ottoman border resulted in some of the most imposing fortified towns being on Croatian territory - Osijek, Slavonski Brod, and Stara Gradiška. Although the formation of most of the fortress-towns began before Prince Eugene’s era, and continued after him, it was the Prince of Savoy that gave them a key signature. By engaging top military engineers, border fortresses and their fortification systems match projects of the most famous European fortress builder - Vauban. At the same time, by including leading state architects in designing the main public and religious buildings within the fortified encloses, Croatian architecture was here enriched by some anthological examples of Baroque. Since this theme has not been fully explored in the national context, and the international scientific public knows hardly anything about it, the aim of this project is to explore the urbanism and architecture of Osijek, Slavonski Brod, Stara Gradiška, Petrovaradin, and evaluate them in the context of Eugene of Savoy’s other fortifications and residences (on the territory of Austria, Bohemia, Hungary, Romania and Serbia).]]></summary_en></project><project>
<id>7681</id><title_hr><![CDATA[Dinamika plodonošenja i očuvanja genofonda hrasta lužnjaka (Quercus robur L.) i obične bukve (Fagus sylvatica L.) u svjetlu klimatskih promjena]]></title_hr><title_en><![CDATA[Dynamic of fructification and conservation of genetic resources of Pedunculate oak (Quercus robur L.) and European beech (Fagus sylvatica L.) in light of climate changes]]></title_en><user_id>5275</user_id><user_firstLast_name>Mladen Ivanković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-8189</code><acronim><![CDATA[CropForClim]]></acronim><duration>01.12.2018 - 30.11.2023</duration><status>Završio</status><financ_value>124.095,83 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Šumarstvo, </scie_field_hr><scie_field_en>Forestry, </scie_field_en><institution_hr><![CDATA[Hrvatski šumarski institut]]></institution_hr><institution_en><![CDATA[Croatian Forest Research Institute]]></institution_en><team_members_id>21001, 19035, 5716, 24012, 17850, 24108, 11314, 24045, 24107, 24110, 44, 12638, 26146, </team_members_id><team_members_names><![CDATA[Anđelina Gavranović, Miran Lanšćak, Marija Gradečki-Poštenjak, Zvonimir Vujnović, Sanja Bogunović, Danijela Ivanković, Vladimir Novotny, Goran Tijan, Luka Jurjević, Robert Licht, Saša Bogdan, Ivica Čehulić, Nikola Zorić, ]]></team_members_names><keywords_hr><![CDATA[hrast lužnjak, obična bukva, plodonošenje, testiranje kvalitete sjemena, okolišni čimbenici, adaptivna genetska raznolikost, pokusi provenijencija]]></keywords_hr><keywords_en><![CDATA[pedunculate oak, common beech, fructification, seed quality testing, environmental factors, adaptive genetic diversity, provenance trials]]></keywords_en><summary_hr><![CDATA[Hrast lužnjak (Quercus robur L.) i obična bukva (Fagus sylvatica L.) su najznačajnije gospodarske vrste listopadnog drveća u Hrvatskoj. Svrha je projekta „Dinamika plodonošenja i očuvanje genofonda hrasta lužnjaka (Quercus robur L.) i obične bukve (Fagus sylvatica L.) u svjetlu klimatskih promjena“ stvoriti odnosno proširiti znanstveno utemeljne preduvjete za očuvanje genetske raznolikosti, gospodarenje i prometovanje reprodukcijskim materijalom ovih vrsta.Ključni ciljevi projekta su:1. Utvrditi dinamiku plodonošenja ciljnih vrsta u promjenjivim okolišnim uvjetima našeg klimatskog područja.2. Uspostaviti metodologiju preciznije procjene uroda.3. Utvrditi korelaciju učestalosti, količine i kvalitete plodonošenja s raznovrsnim okolišnim faktorima.4. Izraditi protokol za optimalno skladištenje sjemena.5. Osnovati eksperimentalne nasade radi ex situ očuvanja genofonda.6. Povećati znanje o adaptivnoj genetskoj raznolikosti provenijencija ovih vrsta u našem području.7. Diseminacija rezultata korisnicima/dionicima (šumarska operativa, zakonodavci, privatni vlasnici i dr.Rezultati istraživanja pružit će bolji uvid u genetsku raznolikost hrasta lužnjaka i obične bukve, kao i bolje razumijevanje prilagodbenog potencijala istraživanih populacija ovih dviju vrsta. Također, rezultati ovoga projekta mogu biti primjenjivi u šumarskoj praksi, a time značajni i za gospodarstvo Republike Hrvatske. ]]></summary_hr><summary_en><![CDATA[Pedunculate oak (Quercus robur L.) and European beech (Fagus sylvatica L.) are the most important economic species of deciduous trees in Croatia. The purpose of the project &#39;&#39;Fructification dynamics and conservation of genetic resources of pedunculate oak (Quercus robur L.) and European beech (Fagus sylvatica L.) in the light of climate change“ is to create and expand the science-based prerequisites for the conservation of genetic diversity, management and trading of reproductive material of these species.The key objectives of the project are:1. Determine seed crop dynamics of the target species in changing environmental conditions of the local climatic region.2. Establish a methodology for more accurate estimation of their seed crops.3. Determine correlation between their masting (quantity and quality of the seed crops) and various environmental factors.4. Create a protocol for optimal seed storage of the target species.5. Establish field trials for ex situ conservation of their genetic resources.6. Increase knowledge about adaptive genetic diversity of the target species in the local region.7. Disseminate results to various users/stakeholders (forestry sector, legislators, private owners, etc.)The results of the research will provide a better insight into the genetic diversity of pedunculate oak and European beech as well as a better understanding of the adaptive potential of the studied populations of these two species. Also, the results of this project may be applied in forestry practice, and therefore significant for the economy of the Republic of Croatia. ]]></summary_en></project><project>
<id>7684</id><title_hr><![CDATA[Pristup utemeljen na znanju za analizu mnoštva ljudi u nadzornim sustavima]]></title_hr><title_en><![CDATA[Knowledge-based Approach to Crow d Analysis in Video Surveillance]]></title_en><user_id>4290</user_id><user_firstLast_name>Slobodan Ribarić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-7619</code><acronim><![CDATA[KACAVIS]]></acronim><duration>01.11.2018 - 30.06.2021</duration><status>Završio</status><financ_value>127.920,90 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>6974, 14818, 4775, 20383, 4593, 4584, 25719, </team_members_id><team_members_names><![CDATA[Tomislav Hrkać, Ivo Ipšić, Marina Ivašić-Kos, Darko Mihalić, Marijo Maračić, Darijan Marčetić, Franjo Matković, ]]></team_members_names><keywords_hr><![CDATA[Analiza mnoštva ljudi, Nadzorni sustav, Sustav temeljen na znanju, Raspoznavanje uzoraka, Analiza ponašanja]]></keywords_hr><keywords_en><![CDATA[Crowd Analysis, Video Surveillance, Knowledge-based, Pattern recognition, Behaviour  Analysis]]></keywords_en><summary_hr><![CDATA[Jedno od trenutno najaktivnijih istraživačkih područja računalnog vida je analiza scena s mnoštvom ljudi (engl. crowd). Mnoštvo se može definirati kao grupa ljudi ili velika skupina pojedinaca okupljenih u istom fizičkom okruženju. Modeliranje mnoštva, analiza scena s mnoštvom i raspoznavanje ponašanja su najzahtjevnije teme računalnog vida i umjetne inteligencije. Znanstveni cilj predloženog istraživanja je razvoj eksperimentalnog inteligentnog sustava utemeljenog na znanju za analizu mnoštva i raspoznavanje ponašanja na temelju vizualnih informacija dobivenih video nadzornim sustavom. Predložen je novi pristup utemeljen na znanju za modeliranje scena s mnoštvom, koji predstavlja spoj metoda utemeljenih na agentima i entitetima, i zdravorazumskog ljudskog znanja. Ideja je pretvoriti ljudsko (ili ekspertno) znanje o ponašanju mnoštva, utemeljeno na vizualnim informacijama, i dodati ga drugim modelima temeljenim na informacijama dobivenim metodama računalnog vida, u bazu znanja koju podržava stroj za zaključivanje. Glavni ciljevi istraživanja su: i) Kritički pregled i analiza ranijih pristupa na području modeliranja i analize mnoštva u sustavima video nadzora; ii) Novi model mnoštva koji se temelji na fuziji agenata i entiteta; iii) Razvijati metode izlučivanja značajki iz videa prilagođene za makroskopsku i mikroskopsku analizu scena s mnoštvom; iv) Pristup modeliranja mnoštva utemeljen na zdravorazumskom znanju; v) Nova arhitektura za hibridno predstavljanje znanja koja kombinira zdravorazumsko ljudsko znanje i koncepte dubokog učenja; vi) Razviti shemu hibridnog predstavljanja znanja te njezinu integraciju s dubokim neuronskim mrežama; vii) klasifikacija ponašanja mnoštva ljudi; viii) Dizajn dubokog modela učenja za analizu scena s mnoštvom; ix) Razvoj eksperimentalnog sustava i njegovo ispitivanje i evaluacija.Važniji ciljevi projekta su diseminacija rezultata istraživanja (tj. objavljivanje časopisa i konferencija) i razvoj karijera mladih istraživača.]]></summary_hr><summary_en><![CDATA[Recently, one of the most active research areas in computer vision is crowd scene analysis. Crowd modelling, crowd scene analysis and behavioural recognition are some of most challenging topics in computer vision and more generally in artificial intelligence. The scientific goal of the proposed research is the development of an experimental intelligent, knowledge-based system for crowd analysis and behaviour recognition based on visual information obtained by video surveillance systems. A proposal is made for a novel knowledge-based approach to modelling crowd scenes, which represents a fusion of agent-based and entity-based approaches, together with human common-sense modelling. The idea is to convert human (or expert) knowledge about crowd behaviour, based on visual information, and to add it to the other models based on information extracted by means of computer vision techniques, in a knowledge base which is supported by an inference engine. The main objectives of the research are: i) to critically review and analyse previous approaches to the field of crowd modelling and analysis in video surveillance systems; ii) to develop a new crowd model based on the fusion of agent-based and entity-based approaches; iii) to develop feature extraction methods from video adapted to macroscopic and microscopic crowd level analyses; iv) to develop a common-sense knowledge approach to crowd modelling; v) to develop a new architecture for hybrid knowledge representation which combines human common-sense knowledge and  deep learning concepts; vi) to develop a hybrid knowledge representation scheme and to integrate it with deep neural networks; vii) to classify crowd behaviour; viii) to design a deep learning model for crowd scene analysis; ix) to develop an experimental system and to test and evaluate it. The important objectives of the project are dissemination (i.e. publishing of journal and conference papers) and young researchers&#39; career development. ]]></summary_en></project><project>
<id>7685</id><title_hr><![CDATA[Visokoenergijska astronomija gama-zraka teleskopima MAGIC i CTA]]></title_hr><title_en><![CDATA[]]></title_en><user_id>19423</user_id><user_firstLast_name>Dijana Dominis Prester</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-5931</code><acronim><![CDATA[MAGIC-CTA]]></acronim><duration>01.10.2018 - 30.09.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Fakultet za fiziku]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Physics]]></institution_en><team_members_id>25265</team_members_id><team_members_names><![CDATA[ Doktorand: Lovro Pavletić ]]></team_members_names><keywords_hr><![CDATA[gama-zrake,  MAGIC, CTA, pulsari, aktivne galaktičke jezgre]]></keywords_hr><keywords_en><![CDATA[gamma rays, MAGIC, CTA, pulsars, active galactic nucleai]]></keywords_en><summary_hr><![CDATA[Visokoenergijska astronomija (VHE) gama-zraka izučava najsilovitije procese u svemiru. Ciljevi ovog projektnog prijedloga su izučavanje emisije VHE gama-zraka iz aktivnih galaktičkih jezgri (AGN), pulsara i proširenih izvora pomoću postojećih teleskopa MAGIC, zatim doprinos dizajnu, izgradnji i puštanju u rad teleskopskog niza Cherenkov Telescope Array (CTA), te analizi prvih podataka prikupljenih tim teleskopima. Analiza VHE gama-zraka iz pulsara omogućit će izučavanje akceleracijskih mehanizmima u magnetosferi neutronskih zvijezda. Za bolje razumijevanje emisijskih mehanizama VHE gama-zraka iz AGN provodit će se opažanja i analizirati korelacije između zračenja u različitim područjima elektromagnetskog spektra. Iako su izvori VHE gama-zraka većinom točkasti, znatan broj ima konačnu kutnu veličinu, za što ne postoji standardizirana analiza podataka. Kako bi se u potpunosti iskoristio potencijal teleskopa MAGIC, a pogotovo budućih teleskopa CTA čije će performance biti za red veličine bolje, razvit ćemo metodu analize proširenih izvora. To će omogućiti izučavanje morfologije izvora VHE gama-zraka, te detekciju drugih izvora opažanih u istom vidnom polju. Monte Carlo simulacijama optimizirat ćemo raspored teleskopa CTA te konfiguracija okidača, za koji će sustav biti najosjetljiviji. Da se dostignu zahtjevane performance Large Size Telescope (LST) (najveći teleskopi u nizu CTA, zrcalo promjera 23 m), nužno je poznavati položaj optičke osi teleskopa u odnosu na centar kamere s preciznošću od 5 lučnih sekundi. Dizajnirati ćemo, testirati, izgraditi i upogoniti sustav za praćenje položaja optičke osi LST teleskopa. Kako na opažani spektar  izvora gama-zraka  Čerenkovljevim teleskopima, utječe  atmosferska transmisija, razvit ćemo novu metodu raspodjele opažačkog vremena koju ćemo testirati na MAGIC teleskopima, a kasnije nadograditi i prilagoditi za potrebe CTA. Razvit ćemo i softverski alat za dugoročno praćenje performansi CTA teleskopa.]]></summary_hr><summary_en><![CDATA[Very high energy (VHE) gamma-ray astronomy studies the most violent processes in the Universe. Aims of this project proposal are study of VHE gamma-ray emission from active galactic nuclei (AGN), pulsars and extended sources using MAGIC telescopes, as well as participation in the design, construction and commissioning of the future Cherenkov Telescope Array (CTA) and analysis of the first data collected with these telescopes. Analysis of VHE gamma-rays from pulsars will enable study of the particle acceleration mechanism in pulsar magnetospheres. A better understanding of the VHE gamma-ray emission mechanisms in AGN will be achieved through observations and correlation analysis of data in different parts of the electromagnetic spectrum. Although mostly point-like, a significant number of VHE sources has a finite angular size, and are not covered by the standard data analysis. In order to fully exploit the potential of the MAGIC telescopes, and in particular the future CTA with even an order of magnitude higher performance, we will develop a method for extended sources data analysis. This will enable study of the morphology of VHE gamma-ray sources, and analysis of other sources observed in the same field of view. Monte Carlo studies will be used to optimize the CTA performance. To achieve the targeted performances of the Large Size Telescope (LST) of CTA, it is necessary to know the position of the telescope optical axis in respect to the centre of the camera with precession of 5 arc seconds. We will design, build and commission the position of the telescope optical axis monitoring system with the required precision. Since the gamma-ray spectra observed by Cherenkov telescopes depend on the atmospheric transmission, an improved observation scheduling method will be developed and implemented first in the MAGIC observation program, and later in the CTA. The software tool for long-term monitoring of the CTA telescope performances will be developed.]]></summary_en></project><project>
<id>7686</id><title_hr><![CDATA[Višerazinski pristup govornom diskursu u jezičnom razvoju]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6147</user_id><user_firstLast_name>Gordana Hržica</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-7002</code><acronim><![CDATA[MultiDis]]></acronim><duration>01.10.2018 - 31.12.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Logopedija, </scie_field_hr><scie_field_en>Logopedics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Edukacijsko-rehabilitacijski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Education and Rehabilitation Sciences]]></institution_en><team_members_id>25250</team_members_id><team_members_names><![CDATA[ Doktorand: Sara Košutar ]]></team_members_names><keywords_hr><![CDATA[govorni diskurs, jezični razvoj, mjere za procjenu diskursa, višerazinski pristup, dvojezični govornici, narušen jezični razvoj, SES]]></keywords_hr><keywords_en><![CDATA[spoken discourse, language development, measures for discourse assessment, multi-level approach, bilingualspeakers, atypical language development, SES]]></keywords_en><summary_hr><![CDATA[U psiholingvistici i primijenjenoj lingvistici procjena proizvedenog diskursa smatra se pouzdanim sredstvom procjene jezičnog znanja (Schneider i sur., 2006; Botting, 2002). Prikupljanje diskursnih uzoraka ekološki je valjano sredstvo procjene jer odražava uporabu jezika u svakodnevnom okruženju. Među različitim pristupima diskursu ističe se višerazinski pristup. Ovaj je pristup teorijska smjernica projektnog prijedloga, iako do sada nije bio primijenjen na područje jezičnog razvoja. Većina se teorija i mjera analize diskursa temelje na engleskom jeziku zbog čega postoji potreba za validacijom podatcima iz tipološki različitih jezika. U ovom projektu za istraživanja će se koristiti postojeći resursi, ali i nadopuniti ili u potpunosti razviti novi (leksičke baze i korpusi). Spoznaje koje će biti rezultat analize tih resursa, poput onih o pojavnosti i čestotnosti različitih struktura u hrvatskom jeziku u određenom razvojnom periodu kod različitih populacija, kao i prilagodbom automatiziranih korpusnih mjera hrvatskome, stvorit će se preduvjeti za razvoj novog materijala za poticanje proizvodnje diskursa. Materijal će se temeljiti na slikovnim predlošcima te će se rabiti računalno uz automatizaciju snimanja, podršku pri transkripciji te izračun mjera za procjenu diskursa. Zbog temeljenosti na prethodnim istraživanjima te psihometrijskih karakteristika materijal će se moći rabiti za jezičnu procjenu, a validacijsko će ispitivanje pružiti pouzdane podatke o razvoju diskursa za različite skupine govornika (jednojezični, dvojezični, narušen jezični razvoj, različit SES) u višerazinskom pristupu.Očekuje se da će se ovim pristupom u projektu a. steći uvid u kognitivne i jezične aspekte ključne za oblikovanje diskursa, b. doprinijeti međunarodnim znanstvenim teorijama i pristupima, c. razviti ili nadopuniti te učiniti javno dostupnima jezične resurse pogodne za druga lingvistička istraživanja te d. doprinijeti spoznajama područjima jezičnog obrazovanja i jezične procjene.]]></summary_hr><summary_en><![CDATA[In the field of psycholinguistics and applied linguistics, discourse analyses have been considered a valuable tool for assessing language knowledge (Schneider et al., 2006; Botting, 2002). The elicitation of discourse samples is an ecologically valid assessment tool since it reflects conversation in everyday environment. A multi-level approach is the main framework of this project proposal. Most of the theories, approaches and discourse analyses measures are based on English language so there is a need for their validation in typologically different languages. In this project new resources will be developed and some existing updated (i.e., lexical database and different corpora). Their analyses will lead to new findings, such as frequency and types of language structures in Croatian in a particular period during language development and in different populations, as well as to development of new automatized corpus measures. These findings will be crucial for development of the new discourse assessment material. Material will be based on picture stimuli in a computer-based application. Application will allow for the automatization of the recording procedure, transcription support and automatic calculation of discourse measures. As the material is grounded in research findings and validated, it will be ready for use as language assessment tool. Validity studies will provide reliable data on discourse development for different groups of speakers (monolingual, bilingual, atypical language development, different SES).It is expected that the project will a. provide a reliable insight into the cognitive and linguistic aspects that underlie the formation of a discourse, b. contribute to the body of research concentrated mainly on English data, c. develop or update language resources in open access needed for diverse linguistic research and d. provide knowledge relevant for language education and language assessment.]]></summary_en></project><project>
<id>7689</id><title_hr><![CDATA[De novo sastavljanje genoma i metagenoma]]></title_hr><title_en><![CDATA[Single-genome and metagenome de novo assembly]]></title_en><user_id>1480</user_id><user_firstLast_name>Mile Šikić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-5886</code><acronim><![CDATA[SIGMA]]></acronim><duration>01.11.2018 - 31.03.2023</duration><status>Završio</status><financ_value>125.571,69 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>3154, 4312, 18950, 7098, 18951, 29054, 864850, 865247, 865540, </team_members_id><team_members_names><![CDATA[Igor Mekterović, Nino Antulov-Fantulin, Robert Vaser, Niranjan Nagarajan, Krešimir Križanović, Dominik Stanojević, Filip Bosnić, Josipa Lipovac, Filip Tomas, ]]></team_members_names><keywords_hr><![CDATA[de novo, assembly, genome, metagenome, seqeuncing]]></keywords_hr><keywords_en><![CDATA[de novo, sastavljanje, genom, metagenom, sekvenciranje]]></keywords_en><summary_hr><![CDATA[Prvi moderni alat za sastavljanje genoma proizvela je Celera 2001. godine za sastavljanje prve verzije ljudskog genoma. Od tada su mnoge metode za sastavljanje genoma razvijene i korištene, ali konačni genomi visoke preciznosti još uvijek zahtijevaju dugotrajan angažman istraživačkih skupina i dugotrajno ručno provjeravanje i prepravljanje. Najveći izazov u proizvodnji visoko preciznih i neprekinutih sastavljenih genoma su dugi nizovi ponavljajući regija. Nove i nadolazeće tehnologije za sekvenciranje tvrtki Pacific Biosciences i Oxford Nanopore Technologies daju nam nadu da je automatizacija postupka sastavljaja genoma moguća. Nove tehnologije proizvode očitanja velike duljine, ali i velikog postotka pogreške. Duljina proizvedenih očitanja može premašiti i nekoliko stotina tisuća nukleotida, što bi trebalo biti dovoljno za ispravnu rekonstrukciju većine ponavljajućih dijelova genoma. Međutim, znanstvena zajednica još uvijek ima značajne poteškoće prilikom sastavljanja većih genoma (genoma životinja i biljaka) te prilikom sastavljanja genoma mikrobnih zajednica. Metode za sastavljanje obično koriste pristup utemeljen na grafovima. Grafovi se grade spajajući očitanja koja se preklapaju, a zatim se heurističkim metodama traži put kroz graf koji će svako očitanje obići samo jednom. To je često nemoguće zbog petlji u grafu, uzrokovanih neispravnim preklapanjima i ponavljajućim djelovima genoma. To je posebno izraženo kod dugih genoma koji se sastoje od većeg broja kromosoma te kod metagenomeskih uzoraka koji sadrže od desetak pa do nekoliko stotina organizama. Glavni cilj ovog projekta jest razviti metode pomoću kojih koje će se proizvesti (i) potpuni i precizni dugi genomi te (ii) genomi organizama iz metagenomskog uzorka. Da bi to postigli planiramo razviti nekoliko metoda utemeljenih na grafovima i strojnom učenju pomoću kojih ćemo detektirati neispravna preklapanja.]]></summary_hr><summary_en><![CDATA[The first modern software for DNA assembly was developed by Celera for generating the draft of human genome in 2001. Since then ample of methods have tried to correctly assemble genomes, but a high-quality assembly still requires laborious work of large groups of scientists and many years of data curation. The biggest challenges for achieving high accuracy and contiguity of genome assemblies have been long stretches of highly repetitive regions. The recent advent of new generation of sequencing technologies such as those of companies Pacific Biosciences and Oxford Nanopore Technologies gives us hope that automated complete genome reconstruction is feasible. They produce long, but error-prone reads whose size exceeds hundreds of thousand nucleotides which should be long enough for spanning most repetitive parts. Nevertheless, researchers still struggle to completely assemble long genomes (ie. animal and plant genomes) and genomes of microbial communities. Assembly methods usually use a graph-based approach which starts with building a graph by joining overlapping reads, followed by using heuristics to find a path which visits each read once. However, this is often unfeasible because of tangles in the graph which occur due to incorrect read overlaps and repetitive regions. This is particularly critical for both long genomes with many chromosomes and for metagenomic samples with anything from ten to several hundred present genomes. The primary aim of this project is the development of methods which will result in (i) complete large genomes and (ii) accurate metagenomic assemblies. To achieve this aim we will develop several graph-based and machine learning methods for detection of incorrect overlaps.]]></summary_en></project><project>
<id>7690</id><title_hr><![CDATA[Razvoj naprednih analitičkih metoda za lijekove i biološki aktivne tvari u liječenju upalnih bolesti crijeva]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1301</user_id><user_firstLast_name>Ana Mornar Turk</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-9047</code><acronim><![CDATA[IBDAnalytics]]></acronim><duration>01.09.2018 - 30.08.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Farmacija, </scie_field_hr><scie_field_en>Pharmaceutical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Farmaceutsko-biokemijski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Pharmacy and Biochemistry]]></institution_en><team_members_id>25223</team_members_id><team_members_names><![CDATA[ Doktorand: Mario-Livio Jeličić ]]></team_members_names><keywords_hr><![CDATA[upalne bolesti crijeva, kromatografija, masena spektrometrija, tehnike pripreme uzoraka, kontrola kvalitete lijekova, dodaci prehrani, biološki lijeko]]></keywords_hr><keywords_en><![CDATA[inflammatory bowel disease, chromatography, mass spectrometry, sample preparation, ADME, quality control, dietary supplements, biopharmaceuticals]]></keywords_en><summary_hr><![CDATA[Upalne bolesti crijeva (UBC) spadaju u skupinu upalnih bolesti kod kojih upalni proces zahvaća područje tankog i debelog crijeva. Odabir farmakoterapije ovisno o proširenosti  i smještenosti bolesti,  neželjenim popratnim pojavama i cijeni. Budući da smanjuju potrebu za koritikosteroidima, imunomodulatori su najčešće propisivani lijekovi u liječenju UBC. Liječenje s monoklonskim protutijelima omogućava liječenje visoko specifičnim i neposrednim mehanizmom djelovanja, ali visoka cijena utječe na učestalost primjene ove skupine lijekova.Budući da upalni procesi u crijevima narušavaju resorpciju vitamina i minerala, pacijentima se preporuča njihova suplementacija tijekom farmakoterapije. Štoviše, nedostatak folne kiseline povećava rizik razvoja tumora kod pacijenata oboljelih od UBC.Velik broj pacijenata smatra dodatke prehrani koje sadrže biljne ekstrakte sigurnim i prirodnim načinom liječenja. Stoga, velik broj pacijenata oboljelih od UBC koriste dodatke prehrani koji sadrže indijski tamjanovac, justiciju i kurkumu.Glavni cilj predloženog istraživanja je razviti nove instrumentalne analitičke metode za kontrolu kvalitete lijekova i dodataka prehrani koji se koriste u liječenju UBC.Kako bi se poboljšala suradljivost pacijenata predložit će se nove fiksne kombinacije imunosupresiva i folne kiseline. Razvit će se metode za ispitivanje farmakokinetike, kontrole kvalitete i terapeutskog praćenja koncentracije lijekova. Razvit će se i analitičke metode za određivanje aktivnih i toksičnih tvari u biljnim dodacima prehrani te će se metode primijeniti za procjenu kvalitete dodataka prehrani na hrvatskom tržištu. Konačno, razvit će se 2D-SE-RP-DAD tehnika za određivanje monoklonskih protutijela i njihovih onečišćenja u biološkim i biosličnim lijekovima.]]></summary_hr><summary_en><![CDATA[Inflammatory bowel disease (IBD) is a group of inflammatory conditions of the colon and small intestine. In IBD, treatment decision is dependent on the stage of the disease, laboratory findings and endoscopic examination. Choice of pharmacotherapy depends largely on the severity of disease, location, side effects and adverse events, as well as cost. Immunosuppressants are the most prescribed drug class in IBD treatment as steroid-sparing therapy. The treatment of IBD with monoclonal antibodies presents high specificity and directed mechanism of action, but the high cost still represents a barrier to be overcome. As the inflammatory process along the digestive tract disrupts resorption of vitamins and minerals, their additional supplementation is recommended with pharmacotherapy therapy. Moreover, low folate intake has been associated with tumor growth in IBD. The majority of the patients consider herbal dietary supplements are safe and natural way of healing. Many patients with IBD take supplements such as Indian frankincense, Justicia and Turmeric. The main objective of the proposed research is to develop new instrumental analytical methods that could be applied in quality control of medicinal products and dietary supplements used in treatment of IBD. A new fix-dose combination of two drugs an immunosuppressant and folic acid to improve patient&#39;s adherence to their prescribed treatment will be proposed. Methods for investigation of pharmacokinetic behaviour, quality control and therapeutic drug monitoring will be developed. Analytical methods for determination of active and toxic compounds of herbal dietary supplements will be developed. The proposed methods will be applied for evaluation of quality assurance for dietary supplements in Croatian marketplace. Finally, an advanced 2D-SE-RP-HPLC/DAD technique will be proposed and applied for determination of monoclonal antibodies and their impurities in biologic drugs and biosimilars.]]></summary_en></project><project>
<id>7692</id><title_hr><![CDATA[Novi pristup razvoju cjepiva za kongenitalnu citomegalovirusnu infekciju]]></title_hr><title_en><![CDATA[New Approach in Development of Vaccine for Congenital Cytomegalovirus Infection]]></title_en><user_id>4958</user_id><user_firstLast_name>Astrid Krmpotić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-9086</code><acronim><![CDATA[VaccongCMV]]></acronim><duration>01.01.2019 - 30.04.2023</duration><status>Završio</status><financ_value>130.814,25 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Medicine]]></institution_en><team_members_id>19695, 5273, 4753, 864864, </team_members_id><team_members_names><![CDATA[Mijo Golemac, Irena Slavuljica, Lea Hiršl, Lydia Gaćina, ]]></team_members_names><keywords_hr><![CDATA[Citomegalovirus, kongenitalna CNS infekcija, receptor NKG2D, cjepivo, CD8 T stanice]]></keywords_hr><keywords_en><![CDATA[Cytomegalovirus, congenital CNS infection, NKG2D receptor, vaccine, CD8 T cells]]></keywords_en><summary_hr><![CDATA[Humani citomegalovirus (HCMV) je najčešći virusni uzročnik kongenitalne infekcije te često uzrokuje dugotrajne neurološke posljedice. Razvoj cjepiva za HCMV je prioritet moderne medicine. Citomegalovirusi (CMV) su specifični za vrstu te je infekcija miševa mišjim CMV-om (MCMV) često korišteni model HCMV-infekcije. NKG2D je snažni aktivacijski receptor stanica NK. Važnost NKG2D u virusnoj kontroli ilustrira činjenica da su CMV-i razvili brojne mehanizme za izbjegavanje kontrole posredovane NKG2D. Mi smo karakterizirali proteine MCMV-a m145, m152 i m155 koji negativno reguliraju ispoljavanje NKG2D-liganada MULT1, RAE-1 and H60. Budući je NKG2D također i kostimulacijski receptor CD8 limfocita T, insercija liganda koji prepoznaje ovaj aktivacijski receptor u genom CMV-a može biti korištena kao novi pristup u dizajniranju cjepiva koja su usmjerena indukciji odgovora CD8 limfocita T. Stoga smo konstruirali rekombinantni MCMV u kojem je NKG2D ligand RAE-1g ubačen u genom MCMV-a na mjesto njegovog inhibitora m152 (RAE-1gMCMV) (Slavuljica i sur. JCI, 2010). RAE-1gMCMV je jako atenuiran in vivo, ali u isto vrijeme potiče snažan i dugotrajan imuni odgovor. U ovom projektu planiramo koristiti rekombinante MCMV koji ispoljavaju druga dva NKG2D liganda, MULT1 i H60, te testirati mogu li rekombinantni CMV koji ispoljavaju različite NKG2D ligande biti korišteni kao cjepivo protiv kongenitalne infekcije CMV-om. Odrediti ćemo imunogeničnost i protektivni kapacitet ovih rekombinantnih virusa. Poseban naglasak ćemo staviti na sigurnosti njihove primjene kao cjepiva. Stoga ćemo na modelu CMV infekcije novookoćenih miševa proučavati razvojne i upalne promjene u mozgu. Konačni cilj ovog projekta je dizajnirati rekombinantno CMV cjepivo koje je sigurno i jako atenuirano i u imunološki nezrelom domaćinu, a u isto vrijeme inducira protektivan i dugotrajan imuni odgovor.    ]]></summary_hr><summary_en><![CDATA[Human cytomegalovirus (HCMV) is the most common viral cause of congenital infections and frequently leads to long-term neurologic sequelae. Development of HCMV vaccine is a high priority of modern medicine. Cytomegaloviruses (CMVs) are species specific and infection of mice with the murine CMV (MCMV) is frequently used model for HCMV infection. NKG2D is a potent activating receptor on NK cells. The importance of NKG2D in virus control is illustrated by the fact that CMVs developed numerous mechanisms to evade NKG2D-mediated control. We have characterize MCMV proteins m145, m152 and m155 involved in the downmodulation of NKG2D ligands MULT1, RAE-1 and H60, respectively. Since NKG2D also acts as a co-stimulatory receptor on CD8 T cells, the insertion of a ligand recognized by this activating receptor into the CMV genome could be used as a new approach in designing vaccines that are directed to the induction of CD8 T cell response. Therefore we constructed recombinant MCMV in which NKG2D ligand RAE-1g was inserted into the MCMV genome in place of its inhibitor m152 (RAE-1gMCMV) (Slavuljica et al. JCI, 2010). RAE-1gMCMV is highly attenuated in vivo but at the same time induces potent and long-lasting immune response. In frame of this project we plan to use recombinant MCMV expressing two other NKG2D ligands, MULT1 and H60, and test whether recombinant CMV expressing various NKG2D ligands could be used as vaccine against congenital CMV infection. Immunogenicity and protective capacity of these recombinant viruses will be determined. Special emphasis will be given on safety of their use as vaccines. To that aim in newborn model of CMV infection developmental changes and inflammation in brain will be studied. The ultimate goal of this project is to design recombinant CMV vaccine which is safe and strongly attenuated even in immunologically immature hosts, but at the same time able to induce protective and long-lasting immune response.]]></summary_en></project><project>
<id>7694</id><title_hr><![CDATA[Dizajniranje, sinteza i evaluacija derivata primakina, vorinostata i sorafeniba kao potencijalnih citostatika]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6143</user_id><user_firstLast_name>Branka Zorc</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-3121</code><acronim><![CDATA[PVSderivatives]]></acronim><duration>10.07.2018 - 02.05.2021</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Farmaceutsko-biokemijski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Pharmacy and Biochemistry]]></institution_en><team_members_id>21322</team_members_id><team_members_names><![CDATA[ Doktorand: Maja Beus ]]></team_members_names><keywords_hr><![CDATA[sinteza, primakin, sorafenib, vorinostat, citostatik]]></keywords_hr><keywords_en><![CDATA[synthesis, primaquine, sorafenib, vorinostat, cytostatic]]></keywords_en><summary_hr><![CDATA[Dugoročni cilj projektnog prijedloga je razvoj novih bioaktivnih spojeva koji mogu dovesti do otkrića potencijalnih vodećih spojeva i antitumorskih lijekova. Projekt je usmjeren na dizajniranje, sintezu i biološko vrednovanje novih derivata primakina, vorinostata i sorafeniba. Primakin je antimalarik, dok su vorinostat i sorafenib citostatici.Potencijal da se novi citostatici razviju iz antimalarika postao je očit nakon otkrića da većina antimalarika djeluje citostatski, a čak sedam registriranih antimalarijskih lijekova nalazi se u kliničkim ispitivanjima kao potencijalni citostatici. Naša istraživačka skupina fokusirala se na primakin, antimalarik s kinolinskom strukturom. U nekoliko naših radova opisani su urea i semikarbazidni derivati primakina sa značajnim citostatskim djelovanjem i/ili velikom selektivnosti. Najveću selektivnost prema staničnim linijama MCF-7 i praktički neaktivnost prema ostalim staničnim linijama karcinoma pokazao je hibrid dviju primakin-urea. Na temelju tih rezultata predviđeno je dizajniranje, sinteza i evaluacija novih hibridnih molekula primakina kao potencijalnih citostatika. Prvo će se sintetizirati dvojni lijekovi primakina i vorinostata 3-8. Ti spojevi će se razlikovati po duljini alifatskog lanca i/ili funkcionalnim skupinama: spojevi opće formule 3 su esteri, 4 su karboksilne kiseline, a 6 hidroksamske kiseline kao i sam vorinostat. Potpunom ili djelomičnom redukcijom 4 priredit će se amini 7 i amidi 8. U ovom projektom prijedlogu predviđena je i sinteza amida primakina s derivatima cimetne kiseline 9 te analoga sorafeniba 14 s pirazinski prstenom, s pretpostavkom da će dodatni atom dušika pojačati vezne interakcije na aktivnom mjestu. Da bi odredili utjecaj supstituenata u amidnom ostatku na fizikalno-kemijska svojstva i jačinu djelovanja, planirana je modifikacija tog dijela molekule.Novi spojevi biti će biološki ispitani na citostatsko djelovanje, inhibiciju specifičnih enzima i antioksidativno djelovanje.]]></summary_hr><summary_en><![CDATA[The long-term goal of the proposed research is development of novel compounds with a potential for development to drug lead(s) and anticancer drug(s). The project will focus on rational design, synthesis and biological screening of novel derivatives of three marketed drugs: antimalarial primaquine and two antitumoral drugs vorinostat and sorafenib.The potential for discovery of new anticancer agents among antimalarials was first noted when commonly used antimalarials showed significant anticancer activity (7 of them have reached a clinical stage of development).  We have focused our attention to primaquine, the antimalarial agent with quinoline moiety. In our several papers novel urea and semicarbazide primaquine derivatives with strong antiproliferative activity and/or high selectivity were reported. The highest selectivity against MCF-7 cells and practically no activity against other tested cancer cell lines showed hybrid of two primaquine ureas. Based on these results we intend to design, synthesize and evaluate novel primaquine hybrid compounds as potential anticancer agents. First objective is to design and prepare novel twin drugs based on primaquine and vorinostat scaffolds 3-6. These compounds will differ in length of aliphatic chain and/or functional groups: compounds 3 are esters, 4 are carboxylic acids and 6 hydroxamic acids like vorinostat itself. Reduction of compounds 4 would generate amines 7 and amides 8. Further on, we plan to prepare primaquine amides 9 with substituted cinnamic acid and sorafenib analogs 14 based on pyrazine structure, hoping that additional nitrogen atom would increase the binding interactions. To study how the amide part of the molecule affects the activity and physico-chemical properties of the new pyrazine analogs, the preparation of a number of amides is planned.All new compounds will be screened for cytostatic activity in vitro on several human cancer cell lines, inhibition of specific enzymes and antioxidative activity.]]></summary_en></project><project>
<id>7695</id><title_hr><![CDATA[Aktivnošću i in silico usmjeren dizajn malih bioaktivnih molekula]]></title_hr><title_en><![CDATA[]]></title_en><user_id>346</user_id><user_firstLast_name>Ines Primožič</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-9357</code><acronim><![CDATA[ADESIRE]]></acronim><duration>23.10.2018 - 31.12.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>25320</team_members_id><team_members_names><![CDATA[ Doktorand: Zlatan Spahić ]]></team_members_names><keywords_hr><![CDATA[dizajn bioaktivnih molekula, sinteza, bioaktivnost, molekularno modeliranje, doking, multi-way analiza]]></keywords_hr><keywords_en><![CDATA[design of bioactive small molecules, synthesis, bioactivity, molecular modelling, docking, multi-way analysis]]></keywords_en><summary_hr><![CDATA[U ovom projektu predložena je sinteza, karakterizacija i biološka evaluacija novih tipova spojeva te ekstenzivni kvantno-kemijski proračuni i multi-way analize. Bioaktivni kemijski skeletni tipovi kao što su benzimidazoli, imidazoli i kinuklidini prepoznati su kao spojevi sa širokim spektrom bioloških aktivnosti, također i u području infektivnih bolesti te poremećaja središnjeg živčanog sustava (Alzheimerova bolest, AD). Mi predviđamo da bi daljnja istraživanja tih klasa kemijskih spojeva mogla rezultirati s identifikacijom novih spojeva prikladnih za daljnji razvoj u moguće lijekove. Kao jako inovativni dio ovog istraživanja, a za razvoj točnih kvantitativnih modela povezivanja strukture i reaktivnosti bit će korištene napredne metode molekularnog modeliranja u kombinaciji s multi-way analizama. Ti modeli će se iskoristiti za iterativni postupak usmjerenog racionalnog dizajna. U početku će se korištenjem klasičnih i suvremenih metoda organske kemije sintetizirati novi bioaktivni spojevi. Za priređene kiralne spojeve odredit će se stereoselektivnost njihovih interakcija. Za sve spojeve, odredit će se antimikrobna aktivnost osobito prema rezistentnim Gram-negativnim bakterijama. Nadalje, njihov potencijal za razvoj poboljšanih lijekova za AD odredit će se mjerenjem njihove inhibicije kolinesteraza. Za procjenu mogućih pozitivnih sinergijskih učinaka, sintetizirat će se hibridne molekule te će se testirati i smjese najaktivnijih sintetiziranih spojeva. Molekularno modeliranje, doking simulacije i novorazvijena metodologija za primjenu multi-way analiza na kombinirane eksperimentalne i teorijske podatke koristit će se za ciljane strukturne promjene koje bi mogle dovesti do novih i efikasnijih bioaktivnih skeletnih tipova s potencijalnom primjenom u biotehnologiji, farmaceutskoj industriji i medicini.]]></summary_hr><summary_en><![CDATA[In this project synthesis, characterization, and biological evaluation of novel types of compounds including extensive quantum chemical calculations and multi-way analyses is proposed. Bioactive chemical scaffolds such as benzimidazoles, imidazoles, and quinuclidines are recognized as compounds with a broad spectrum of biological activities also in the fields of infectious diseases and central nervous system disorders (Alzheimer’s disease, AD). We envisioned that further exploration of these chemical classes can result with the identification of new leads suitable for further development into potential hits. As a highly innovative part of this study, advanced methods of molecular modelling combined with multi-way analysis will be used for construction of accurate quantitative structure–activity relationship models. These models will be used for iterative procedure of guided rational design. Initially, new bioactive compounds will be synthesized using classical and contemporary methods of organic chemistry. Chiral compounds will be prepared and the stereoselectivity of interactions evaluated. For all compounds, antimicrobial activity will be estimated targeting resistance genes to treat infections caused by multidrug-resistant Gram-negative bacteria. Furthermore, their perspective for development of enhanced anti-AD drugs will be assessed by determining their inhibitory potency toward cholinesterases. To evaluate possible beneficial synergistic effects, hybrid molecules as well as various combinations of the most active synthesized compounds will be prepared and tested. Molecular modelling, docking studies and a newly developed method for application of multi-way analysis to combined experimental and theoretical data will be used to direct structural changes leading to the synthesis of new, more efficient bioactive scaffolds with potential use in biotechnology, pharmaceutical industry and medicine.]]></summary_en></project><project>
<id>7698</id><title_hr><![CDATA[Epigenetički biomarkeri u krvi i ejakulatu bolesnika sa seminomom testisa]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3016</user_id><user_firstLast_name>Davor  Ježek</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-4076</code><acronim><![CDATA[]]></acronim><duration>01.10.2018 - 01.09.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>25371</team_members_id><team_members_names><![CDATA[ Doktorand: Dora Raos ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>7699</id><title_hr><![CDATA[Nastajanje i svojstva 1D a-Fe2O3 nanostruktura dopiranih odabranim metalnim ionima]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1073</user_id><user_firstLast_name>Stjepko Krehula</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-6574</code><acronim><![CDATA[1D-DopedFeOX]]></acronim><duration>04.09.2018 - 03.12.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>25288</team_members_id><team_members_names><![CDATA[ Doktorand: Nina Popov ]]></team_members_names><keywords_hr><![CDATA[a-Fe2O3, 1D nanostrukture, dopiranje, Mossbauerova spektroskopija, elektronska mikroskopija, magnetska svojstva, fotokataliza]]></keywords_hr><keywords_en><![CDATA[a-Fe2O3, 1D nanostructures, doping, Mossbauer spectroscopy, electron microscopy, magnetic properties, photocatalysis]]></keywords_en><summary_hr><![CDATA[U zadnje vrijeme 1D (jednodimenzijski) željezovi oksidi su predmet brojnih fundamentalnih istraživanja kojima se žele polučiti nova saznanja o kemijskim i fizičkim svojstvima tih materijala te na temelju toga predložiti primjene u različitim tehnologijama, posebno u naprednim. Pri tome je važno uspostaviti odnose između vrste i uvjeta kemijske sinteze te svojstava istraživanog materijala kao što su morfologija i veličina čestica s promjenama u strukturnim, magnetskim i optičkim svojstvima. Cilj predloženih istraživanja je polučiti nova saznanja o kinetici, faznoj transformaciji i mehanizmu nastajanja 1 D a-Fe2O3. Kontroliranim dopiranjem odabranim metalnim ionima, nastojat će se poboljšati optička, magnetska i katalitička svojstva 1D a-Fe2O3. Istraživat će se nanostrukture u području od finih anizotropnih nanočestica do nekoliko stotina mikrometara dugih nanovlakana. Budući da formiranje specifičnih nanostruktura ovisi o brojnim eksperimentalnim parametrima, posebna pažnja će se posvetiti praćenju kinetika te faznim transformacijama tijekom nastajanja nanostruktura a-Fe2O3 upotrebom sofisticiranih strukturnih, mikroskopskih i spektroskopskih instrumentalnih tehnika. Za ostvarenje postavljenih ciljeva predlažu se sljedeća istraživanja: (I) praćenje kinetike i fazne transformacije nastajanja nedopiranih i dopiranih 1D a-Fe2O3 nanostruktura iz koncentriranih ili djelomično neutraliziranih otopina FeCl3, (II) razvoj novih sintetčkih postupaka dobivanja vrlo dugih nedopiranih i dopiranih nanovlakana a-Fe2O3 metodom elektroispredanja i (III) testiranje fotokatalitičke aktivnosti sintetiziranih 1D nanostruktura a-Fe2O3. Osim stjecanja novih temeljnih znanja o 1D nanstrukturiranim materijalima, priredit će se i materijali točno definiranih fizičko-kemijskih svojstava.]]></summary_hr><summary_en><![CDATA[1D (one-dimensional) iron oxides are in the focus of many researchers due to the importance of these materials in fundamental research and their high potential in advanced technologies. The knowledge of relationship  between the chemical and physical properties on one side and the synthesis conditions on the other is extremely important, especially when 1D iron oxides (undoped or doped) with desired properties must be designed. This proposal aims to provide new knowledge about the kinetics, phase transformation and the mechanism of the formation of 1D a-Fe2O3 in dependence of various experimental parameters. In order to pronounce their optical, magnetic and catalytic  properties control doping with selected metal ions will be performed using different experimental approaches. The 1D a-Fe2O3 oxide nanostructures will be investigated in the range from fine anisotropic nanoparticles up to several hundred microns long nanofibers. Since the formation of specific nanostructures is dependent on many experimental parameters a special attention in this proposal will be given to the monitoring of the formation kinetics and phase transformations using sophisticated instrumental techniques such as structural, spectroscopic and microscopic techniques. To achieve the objectives of the proposal the following investigations will be done: (i) monitoring the kinetics, phase transformation and mechanism of the formation of undoped and metal-doped 1D a-Fe2O3 nanostructures from concentrated or partially neutralized FeCl3 solutions, (II) development of new procedures in the formation of very long nanofibers of undoped and metal doped a-Fe2O3 using electrospinning methods and (III) testing the photocatalytic activity of synthesized 1D a-Fe2O3 nanostructures. This proposal is aimed to gain new fundamental knowledge on the formation of 1D nanostructured materials in general, but will also provide the materials with defined physicochemical properties.]]></summary_en></project><project>
<id>7701</id><title_hr><![CDATA[Istraživanje razvoja, diferencijacije i evolucije životinja kroz genomiku bazalnih metazoa ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1187</user_id><user_firstLast_name>Kristian Vlahoviček</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-6729</code><acronim><![CDATA[BAMGEN]]></acronim><duration>20.10.2018 - 20.12.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>25324</team_members_id><team_members_names><![CDATA[ Doktorand: Silvestar Beljan ]]></team_members_names><keywords_hr><![CDATA[regulacija gena, genomika, transkriptomika, spužve, genomika raka]]></keywords_hr><keywords_en><![CDATA[gene regulation, genomics, transcriptomics, sponges, cancer genomics]]></keywords_en><summary_hr><![CDATA[Projekti velikih razmjera koji uključuju metode -omike priskrbili su veliku količinu znanja o molekularnim mehanizmima u stanicama i tkivima ljudi i modelnih organizama, te pružili mnoštvo informacija o raznolikosti staničnih procesa, poglavito genske regulacije. Ti su projekti ujedno razotkrili neizmjernu kompleksnost životinjske stanice, potencijal za diferencijaciju u stanice različitih tkiva, gubitak kontrole pri nastajanju raka, te time potakli niz dubljih pitanja na različitim područjima znanosti o životu: Kako funkcionira diferencijacija u specifične stanice tkiva? Koliko su mehanizmi genske regulacije očuvani kroz životinjsko carstvo? Odakle potječe kompleksnost procesa diferencijacije? I, konačno, koje je porijeklo višestaničnosti?  Bazalne životinje (Metazoa), ključne su za odgovore na ova pitanja: mi na njih namjeravamo odgovoriti proučavanjem ne-modelnih organizama na samom dnu životinjskog evolucijskog stabla - najjednostavnijim višestaničnim životinjama - spužvama (Porifera). Spužve su najstarije danas živuće životinje koje su se vjerojatno najranije odvojile na razvojnom stablu životinja, te posjeduju neka izvanredna svojstva koja ih čine idealnim modelom za istraživanja regulacije gena uključenih u razvoj: u bliskoj su simbozi s jednostaničnim prokariotima, sadrže mali broj osnovnih tipova stanica, nemaju pravih tkiva, organa ni zametnih listića, a istovremeno posjeduju mnoge gene uključene u rani razvoj i povezane s nastankom raka, kao i totipotentne stanice. Metodama komparativne genomike i transkriptomike, htjeli bismo istražiti procese unutar simbioze, kao i procese razvoja i diferencijacije stanica za koje vjerujemo da su naslijedile sve višestanične životinje.  Pomoću čvrste mreže suradnika, stručnjaka u području biologije Metazoa s iskustvom u  metodama genomike i računalne biologije kompleksnih sustava, te preliminarnim setom zanimljivih rezultata, namjeravamo odgovoriti na prethodno postavljena pitanja i interdisciplinarnim pristupom razjasniti neka od ključnih otvorenih pitanja na području genomike i evolucije čitavog životinjskog carstva.]]></summary_hr><summary_en><![CDATA[Large scale –omics projects have provided valuable knowledge on the molecular mechanisms occurring in cells and tissues of human and other related model organisms, delivering a wealth of information on the diversity of cellular processes, and in particular gene regulation. Yet, these projects have also uncovered the immense complexity of the animal cell, its potential to differentiate into various tissues, or spiral out of control by forming cancer, opening up even more profound questions on diverse fronts of the life sciences: How does tissue-specific cell differentiation work? How conserved are gene regulation mechanisms throughout animal kingdom? Where does complexity of differentiation originate from? And, finally, what is the origin of multicellularity?Basal metazoans hold key answers to these questions: we propose to tackle them by investigating the non-model organisms at the very base of the animal evolutionary tree – the simplest multicellular animals – sponges (Porifera). Sponges, are probably the earliest branching and the oldest extant animals. They hold remarkable properties that make them an excellent subject for studying developmental gene regulation: a handful of major cell types, no true tissues and organs, and no germ layers, but at the same time they are rich in early developmental genes associated to cancer and possessing totipotent cells. With the aid of comparative genomics and transcriptomics, we wish to explore developmental and cell differentiation processes that we believe are ancestral to all multicellular animals.With a strong collaboration network, expert base in metazoan biology, expertise in genomics and computational biology of complex systems, and a preliminary set of interesting results, we propose to answer the above questions through a truly interdisciplinary approach and elucidate some of the crucial open questions in genomics and evolution of the entire animal kingdom. ]]></summary_en></project><project>
<id>7705</id><title_hr><![CDATA[Stručno usavršavanje učitelja u funkciji unapređenja rezultata učenja učenika osnovne škole u prirodoslovnom i matematičkom području]]></title_hr><title_en><![CDATA[Professional Development of Teachers with the Purpose of Improving the Learning Outcomes in Natural Sciences and Mathematics]]></title_en><user_id>23398</user_id><user_firstLast_name>Branko Bognar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-8363</code><acronim><![CDATA[SURFPRIMA]]></acronim><duration>01.12.2018 - 31.08.2023</duration><status>Završio</status><financ_value>81.555,48 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Pedagogija, </scie_field_hr><scie_field_en>Pedagogy, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>6800, 6862, 23512, 4420, 23505, 3753, 23604, 6817, 23482, 23588, 23520, 861736, 862785, 861599, 861598, 867436, 867440, 867439, </team_members_id><team_members_names><![CDATA[Renata Jukić, MIRKO LUKAŠ, Diana Moslavac Bičvić, Irena  Labak, Mirela Skelac, Siniša Opić, Ljerka Jukić Matić, Marija Sablić, Marina Ništ, Jelena Noskov, Alma Škugor, Mia Filipov, Ana Mirosavljević, Ozrenka Meštrović, Jasenka Meštrović, Sanela Mužar Horvat, Darko Samardžić, Magdalena Mikulić, ]]></team_members_names><keywords_hr><![CDATA[akcijsko istraživanje, eksperimentalno istraživanje, nastava biologije, nastava matematike, stručno usavršavanje učitelja, video tehnologija]]></keywords_hr><keywords_en><![CDATA[action research, biology teaching, experimental research, mathematics teaching, teacher professional development, video technology]]></keywords_en><summary_hr><![CDATA[U većini obrazovnih sustava ne postoji značajna povezanost između stručnog usavršavanja učitelja i rezultata njihovih učenika. Unatoč tome, ne bi bilo dobro zaključiti kako stručno usavršavanje općenito ne doprinosi promjenama u nastavi, već samo da postojeće stručno usavršavanje nije dovoljno učinkovito te da bi ga trebalo mijenjati. Učinkovito stručno usavršavanje je kontinuirano, integrirano s područjem primjene, aktivno i dobro vođeno. Ono uključuje učenje po modelu te refleksivne zajednice prakse za što se mogu koristiti mrežne aplikacije i video zapisi nastave. Svrha ovog projekta je razvoj i provjera učinkovitosti modela stručnog usavršavanja učitelja biologije i matematike koji može doprinijeti kvaliteti učenja učitelja, bitnim promjenama u nastavi i rezultatima koje postižu učenici. Projekt će biti ostvaren kroz četiri faze od kojih će svaka trajati godinu dana. Prva faza namijenjena je ispitivanju stanja u svezi stručnog usavršavanja i pripremi akcijskog i eksperimentalnog istraživanja koje će biti ostvareno tijekom druge, odnosno treće faze istraživanja. U završnoj fazi na temelju analize rezultata prethodno provedenih istraživanja razradit ćemo model stručnog usavršavanja primjenjiv u hrvatskom obrazovnom kontekstu koji ćemo prezentirati stručnoj i znanstvenoj javnosti.S obzirom da u Hrvatskoj ne postoje istraživanja stručnog usavršavanja u kojima su praćene promjene u nastavi i rezultati učenja učenika, radovi koje namjeravamo publicirati mogu doprinijeti spoznajama u svezi mogućnosti stvaranja učinkovitog stručnog usavršavanja, a time i boljim rezultatima naših učenika. ]]></summary_hr><summary_en><![CDATA[In most education systems, there is no significant association between the teacher&#39;s professional development and the results of their students. Nevertheless, it would not be good to conclude that the professional development in general does not contribute to changes in teaching, but only that existing professional development is not efficient enough and that it should be changed. Effective professional development should be directed to a specific teaching area. It should offer active and collaborative learning for teachers starting from the best practice models. It should be well-managed. Teachers need timely feedback and reflection. In order to make reflections, video presentations are increasingly used. Finally, to make changes in the teaching process, continuity and time are needed. The purpose of this project is to develop and verify the effectiveness of a model of professional development appropriate to the Croatian educational context that can contribute to the quality of teacher&#39;s learning, substantial changes in teaching and the achievements of students in biology and mathematics. The project will be realized through four phases, each of which will last for one year. The first phase is aimed at examining the state of the professional development and the preparation of action and experimental research that will be realized during the second and the third phase of the project. In the final phase, based on the analysis of the results of the previous research, we will devise a model of professional development applicable in the Croatian education system. Since there are no research studies on professional development in Croatia exploring changes in teaching and student&#39;s learning outcomes, the accounts we intend to publish can contribute to the knowledge about the possibilities of creating effective professional development, especially for teachers in science and mathematics where our students are less successful.]]></summary_en></project><project>
<id>7707</id><title_hr><![CDATA[Elektromagnetske strukture za nadolazeće generacije  komunikacijskih sustava ]]></title_hr><title_en><![CDATA[ Electromagnetic Structures for Emerging Communication Systems]]></title_en><user_id>18913</user_id><user_firstLast_name>Silvio Hrabar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-9753</code><acronim><![CDATA[ELESECOM]]></acronim><duration>01.11.2018 - 30.04.2023</duration><status>Završio</status><financ_value>132.926,08 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>6686, 7123, 6808, 6555, 24468, 865115, 23810, 865118, 2656, </team_members_id><team_members_names><![CDATA[Zvonimir Šipuš, Igor Krois, Juraj Bartolić, Davor Bonefačić, Leo Vincelj, Dominik Žanić, Dominik Barbarić, Dubravko Tomić, Boris Okorn, ]]></team_members_names><keywords_hr><![CDATA[elektromagnetizam, metamaterijali, antene, bežični senzori, nefosterovske mreže]]></keywords_hr><keywords_en><![CDATA[electromagnetics, metamaterials, antennas, wireless sensor, non-Foster network]]></keywords_en><summary_hr><![CDATA[Jedan od glavnih zahtjeva i pokazatelja kvalitete naprednih bežičnih komunikacijskih sustava je mogućnost komuniciranja s velikim brojem korisnika i uređaja koristeći velike brzine prijenosa. Stoga je izgradnja odgovarajućih antena i pripadajućeg sklopovlja  za upravljanje  tokom elektromagnetske energije svakako veliki inženjerski izazov. Takvi antenski sustavi uključuju svojstva širokopojasnog rada, višestruku funkcionalnost, upravljanje različiitm snopovima i / ili višestruki višestruki izlazno-ulazni  način rada (MIMO), kontrolu polarizacije, prostorno i frekvencijsko filtriranje, aktivno i pasivno suzbijanje smetnji, čak uključujući radiofrekvencijsku obradu signala unutar sklopovlja antena. Trenutačno nije jasno koja bi tehnologija bila najbolji izbor za ispunjavanje svih ovih zahtjeva. Elektromagnetska skupina na Sveučilištu u Zagrebu iskoristit će svoje nedavne  rezultate istraživanja u metamaterijalima korištenjem tri komplementarna pristupa za uporabu u antenama i pripadajućim elektromagnetnim strukturama za buduće komunikacijske sustave. Prvi pristup temelji se na periodičnim strukturama za vođenje elektromagnetske energije u kombinaciji s lećama i metapovršinama. Ovaj pristup će dovesti do milimetarskih antenskih nizova s visokom učinkovitošću. Drugi pristup poboljšat će svojstva sustava ugradnjom naprednih aktivnih metamaterijalnih struktura kao što su radiofrekvencijski linearni i nelinearni podsustavi s negativnom impedancijom. Ovi aktivni podsustavi će omogućiti upravljanje glavnom zrakom i kontrolu polarizacije, zajedno s pretvorbom prema gore i prema dolje, te svojstvom samo-osciliranja. Treći se pristup bavi novom bežičnom senzorskom tehnologijom u milimetarskom režimu. U završnom dijelu projekta pokušat će se kombinirati znanje postignuto korištenjem sva tri pristupa integracijom u višenamjenski elektromagnetski sustav, prikladan za uporabu u novim sustavima komunikacija, senzora i pozicioniranja.]]></summary_hr><summary_en><![CDATA[One of the main requirements and quality indicators of the advanced wireless communications systems is the ability to communicate with a large number of users and devices with high-speed connections. Therefore,  construction of  the appropriate antennas and associated hardware for steering the flow of electromagnetic energy in emerging communication systems is certainly a big engineering challenge. The required properties of these antenna systems will include broad frequency-band operation, multi-functionality, beam steering and/or multiple-input multiple-output (MIMO) mode of operation, polarization control, spatial and frequency filtering, active and passive interference suppression including radiofrequency signal processing.  At the moment, it is not clear which technology would be the best choice for meeting these requirements. The electromagnetic group at University of Zagreb will leverage their recent advances in metamaterials by investigation of three complementary approaches for use in the antennas and associated electromagnetic structures for future emerging communication systems. The first approach will be based on the guiding periodic structures combined with lenses and metasurfaces. This approach will lead to millimeter antenna arrays with high efficiency. The second approach will enhance the system properties by incorporation of advanced active metamaterial-inspired structures such as negative-impedance linear and non-linear processing subsystems. These active subsystems will add tunability, steering and polarization control, together with up-conversion, down-conversion and self-oscillating properties.  The third approach will deal with novel wireless sensor technology in millimeter regime.  In the final part of the project, it will be attempted to combine knowledge achieved using all three approaches towards integration into a multi-functional electromagnetic system, convenient for use in emerging communications, sensing and positioning systems.]]></summary_en></project><project>
<id>7712</id><title_hr><![CDATA[Selektivno ciljanje matičnih stanica sarkoma askorbinskom kiselinom]]></title_hr><title_en><![CDATA[Ascorbic Acid for Selective Targeting of Sarcoma Stem Cells ]]></title_en><user_id>3273</user_id><user_firstLast_name>Inga Marijanović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-7590</code><acronim><![CDATA[ASTar]]></acronim><duration>22.10.2018 - 21.04.2023</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, Kemija, </scie_field_hr><scie_field_en>Biology, Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>955, 4688, 23970, 23958, 4398, 24224, 28662, </team_members_id><team_members_names><![CDATA[Marijan Gotic, Katarina Caput Mihalić, Tadija Petrović, Marijana Šimić Jovičić, Alan Ivković, Robert Kolundžić, Maja Ledinski, ]]></team_members_names><keywords_hr><![CDATA[sarkom, tumorske matične stanice, sarkosfere, askorbinska kiselina, čvrste lipidne nanočestice]]></keywords_hr><keywords_en><![CDATA[sarcoma, cancer stem cells, sarcospheres, ascorbic acid, solid lipid nanoparticles]]></keywords_en><summary_hr><![CDATA[Sarkomi su prilično smrtonosni oblici raka, ponajprije zbog kasne dijagnoze i uznapredovalosti pri pojavi simptoma. Zbog niske učestalosti i velikog broja podvrsta, sarkomi su zahtjevna bolest. Upravo stoga, potrebno je ciljati njihovu zajedničku osobinu, a to je postojanje matičnih stanica sarkoma. One predstavljaju mali udio u staničnoj populaciji tumora koje imaju sposobnost inicijacije tumora. Otporne su na terapije i zadržavaju sposobnost regeneracije tumora. Zbog specifičnosti matičnih stanica sarkome, za njihovo uništenje potrebno je ciljati molekularne različitosti. Matične stanice sarokoma se, kao i druge matične stanice, smatraju mirujućima te imaju karakterističan metabolički profil i redox stanje. Naši preliminarni rezultati ukazuju da askorbinska kiselina (AA) ima jak citotoksični učinak na matične stanice sarkoma dok ne utječe na vijabilnost drugih stanica. Stoga bi željeli pobliže istražiti utjecaj AA na matične stanice sarkoma analizirajući njene različite oblike – AA, dehidroksiaskorbinsku kiselinu (DHA) i askorbil palmitat (AP). Kako bi izbjegli ozbiljne nuspojave prilikom potencijalne kliničke primjene, ugradit ćemo AA, DHA i AP u čvrste lipidne nanočestice (SLN). Matične stanice sarkoma i primarne stanice sarkoma iz 30 pacijenata, mezenhimske matične stanice i stanične linije U2OS i HEK293 tretirat ćemo s AA, DHA i AP bez is a SLN. Odredit ćemo staničnu vijabilnost, vrstu stanične smrti i optimalno doziranje. Također ćemo analizirati profil onkogena i tumor supresora 30 sarkoma i istražiti mehanizme selektivnog ciljanja koristeći panele metabolizma i oksidativnog stresa. Ukoliko je osjetiljivost na AA specifična za matične stanice sarkoma, velika je vjerojatnost da je specifična i za matične stanice drugih tumora. Stoga bi ovi rezultati mogli imati velik klinički značaj jer bi se AA mogla koristiti kao adjuvantna terapija uz standardne lijekove s ciljem uništenja matične populacije stanica unutar tumora. ]]></summary_hr><summary_en><![CDATA[Sarcomas are quite deadly forms of cancer, primarily due to delayed diagnosis and advanced disease at presentation. The rarity of the disease combined with the diverse number of subtypes make sarcomas challenging. Therefore, it is important to target their common feature – the existence of sarcoma stem cells. They represent a small fraction of the cellular population of tumor that have the tumor-initiation capacity. They are resistant to current therapies retaining the capacity to regenerate tumor. Due to their specific properties, eradication of sarcoma stem cells requires targeting their molecular differences. Sarcoma stem cells, as other cancer stem cells, are generally considered quiescent with specific metabolic profile and redox state. Our preliminary data suggest that ascorbic acid (AA) has a strong cytotoxic effect on sarcoma stem cells while it does not interfere with viability of other cell types. Therefore, we would like to explore further the impact of AA on sarcoma stem cells by analyzing different its different forms – AA, dehydroascorbic acid (DHA) and ascorbic palmitate (AP). To avoid serious side effects in potential clinical application, we will incorporate AA, DHA and AP in solid lipid nanoparticles (SNPs). Sarcoma stem cells and primary sarcoma cells derived from 30 patients, mesenchymal stem cells, U2OS and HEK293 cell lines will be treated with AA, DHA and AP with and without SNP packaging. We will determine cell viability, cell death modality and dosage effect. Also, we will analyze oncogene/tumor suppressor profile from 30 sarcomas and explore mechanism of selective targeting using metabolic and oxidative stress panels. If sensitivity to AA is a property of sarcoma stem cells, there is a high probability that it is property of other cancer stem cells as well. Therefore, these data could have important and interesting clinical consequences as AA could be used as an adjuvant to standard therapy to eradicate tumor stem cell population.]]></summary_en></project><project>
<id>7718</id><title_hr><![CDATA[Arheološki krajolik u održivom razvoju kulturnog turizma Općine Vrsar (ArchaeoCulTour)]]></title_hr><title_en><![CDATA[]]></title_en><user_id>823</user_id><user_firstLast_name>Robert Matijašić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-7843</code><acronim><![CDATA[]]></acronim><duration>01.10.2018 - 30.09.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Arheologija, </scie_field_hr><scie_field_en>Archeology, </scie_field_en><institution_hr><![CDATA[Sveučilište Jurja Dobrile u Puli]]></institution_hr><institution_en><![CDATA[Juraj Dobrila University of Pula]]></institution_en><team_members_id>21367</team_members_id><team_members_names><![CDATA[ Doktorand: Katarina Šprem ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>7719</id><title_hr><![CDATA[Model rasta aneurizme temeljen na biokemijskim i mehaničkim podražajima ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1010</user_id><user_firstLast_name>Igor Karšaj</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-5244</code><acronim><![CDATA[BCMModAneuGr]]></acronim><duration>01.10.2018 - 31.12.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, </scie_field_hr><scie_field_en>Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>25392</team_members_id><team_members_names><![CDATA[ Doktorand: Josip Živić ]]></team_members_names><keywords_hr><![CDATA[aneurizma, abdominalna aorta, intraluminalni tromb, rast i promjena strukture, hiperelastičnost, naprezanja, prilagodba, razgradnja elastina, kolagen]]></keywords_hr><keywords_en><![CDATA[aneurysm, abdominal aorta, intraluminal thrombus, growth and remodeling, hyperelasticity, stress, adaptation, elastin degradation, collagen turnover]]></keywords_en><summary_hr><![CDATA[Modeliranje biokemijskih kao i mehaničkih promjena tijekom razvoja intraluminalnog tromba (ILT) ima potencijal da pomogne nam odgovoriti na pitanje kako dolazi do rasta aneurizme i što uzrokuje njenu rupturu. Konačni cilj ovog istraživanja je utvrditi promjene koje s javljaju rastom aneurizme. Simulirat ćemo od početnog krvnog ugruška pa kasnog stadija aneurizme promjera većeg od 5 cm. Pretpostavljamo da povećanje AAA je izravna posljedica razvoja ILT.  Predlažemo sljedeće ciljeve za ovaj projekt:Cilj 1: Razviti model rasta i promjene strukture fuziformne aneurizme koji je moguće koristiti u paketu za konačne elemente.Cilj 2: Potrebno je razviti trodimenzijski model rasta i promjene strukture sakularne aneurizme s uključenim intraluminalnim trombom.Cilj 3: Potrebno je ispitati različite hipoteze o tome kako dolazi do rupture ili stabilizacije AAA na realističnoj geometriji.Uspješno ostvarenje navedenih ciljeva bit će veliki napredak u polju biomehanike krvnih žila jer će omogućiti po prvi put praćenje kinetike razvoja intraluminalnog tromba unutar AAA i otkrivanje faktora koji utječu na rast i rupturu aneurizme.]]></summary_hr><summary_en><![CDATA[Proper biochemomechanical modeling of the development of an intraluminal thrombus (ILT) has the potential to help us answer the question about reasons for aneurysmal growth and to define parameters influencing potential for rupture?. The overall goal of this project, therefore, is to quantify the development of ILT from the initial blood clot to a mature formation, with special attention to changes in the clot structure. Our hypothesis is that AAA growth is a direct consequence of ILT development. We propose following aims for this proposal:Aim 1: To develop a finite element growth and remodeling model of thrombus-laden fusiform aneurysm from the moment of initiation.Aim 2: To develop a 3-D finite element growth and remodeling model of thrombus-laden saccular abdominal aortic aneurysm from the healthy aorta.Aim 3: To test different hypothesis on AAA rupture and stabilization on realistic geometry from Aim 2.Successful realization of these aims will advance the field of vascular mechanics by allowing for the first time quantification of kinetics of an intraluminal clot within AAA, and factors that significantly influence aneurysmal growth and risk of the rupture. ]]></summary_en></project><project>
<id>7720</id><title_hr><![CDATA[Metode i algoritmi za poboljšanje slika u boji u stvarnom vremenu]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5393</user_id><user_firstLast_name>Sven Lončarić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-1993</code><acronim><![CDATA[PerfectColor]]></acronim><duration>22.10.2018 - 22.10.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>25373</team_members_id><team_members_names><![CDATA[ Doktorand: Karlo Koščević ]]></team_members_names><keywords_hr><![CDATA[obrada slike, poboljšanje slike, konstantnost boja, preslikavanje tonova, balans bijele boje]]></keywords_hr><keywords_en><![CDATA[image processing, image enhancement, color constancy, tone mapping, white balance]]></keywords_en><summary_hr><![CDATA[Poboljšanje slika u boji je važan problem u mnogim primjenama obrade slika. Razvoj senzora slike i rastuće potrebe tržišta za naprednim rješenjima koja su temeljena na tehnologijama obrade slika su glavni razlozi za sve veću važnost tehnika za poboljšanje slika. Algoritmi za obradu slika koji se koriste u ugradbenim računalnim sustavima kao što su digitalne kamere imaju oštra ograničenja s obzirom na rad u stvarnom vremenu te ograničenja tehnologije korištene za sklopovsku implementaciju, kao npr. FPGA tehnologija. Većina metoda i algoritama objavljenih u literaturi nisu prikladni za rad u stvarnom vremenu zbog njihove složenosti ili jer su neprikladni za sklopovsku izvedbu. Sveukupni cilj projekta je unaprjeđenje dviju važnih operacija za poboljšanje slika, algoritama za postojanost boja i preslikavanja intenziteta slike, koji su prisutni  u mnogim ugradbenim sustavima kao što su npr. digitalne kamere, kroz razvoj novih metoda za rad u stvarnom vremenu koje se i sklopovski daju učinkovito ostvariti. Glavni ciljevi ovog prijedloga su istraživanje i razvoj 1) metoda za postojanost boja koje rade u stvarnom vremenu i 2) metoda za preslikavanje intenziteta slike za rad u stvarnom vremenu. Uz to, bit će razvijene dvije nove baze slika koje će imati važan utjecaj na cijelu istraživačku zajednicu u području postojanosti boja. ]]></summary_hr><summary_en><![CDATA[Color image enhancement is an important problem in many image processing applications. Development of image sensors and growing market demand for advanced solutions that are based on the image processing technology are the main factors for increasing importance of image enhancement techniques. In particular, image processing algorithms used for embedded systems such as digital cameras have strict requirements in terms of real-time operation and hardware constraints imposed by specific technology used for embedded implementation, such as FPGA technology. Most methods and algorithms published in the literature are not suitable for real-time operation due to their complexity or due to being hardware unfriendly so their embedded implementations are too complex and unable to satisfy strict requirements of real-time applications. The overall goal of this project proposal is to improve two important image enhancement tasks of color constancy and tone mapping found in many embedded systems such as digital cameras by proposing new practically implementable methods that are capable of real-time operation. The main objectives of this research proposal are research and development of: 1) methods for real-time color constancy, and 2) methods for real-time tone mapping. In addition, two new image datasets that are to be created during this research, will certainly have an important impact on the whole research field of color constancy.]]></summary_en></project><project>
<id>7721</id><title_hr><![CDATA[Zeleni modularni putnički brod za Mediteran]]></title_hr><title_en><![CDATA[]]></title_en><user_id>252</user_id><user_firstLast_name>Nikola Vladimir</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-4766</code><acronim><![CDATA[ZEMP / GRiMM]]></acronim><duration>01.10.2018 - 20.11.2023</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Brodogradnja, </scie_field_hr><scie_field_en>Naval architecture, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>25261</team_members_id><team_members_names><![CDATA[ Doktorand: Maja Perčić ]]></team_members_names><keywords_hr><![CDATA[putnički brod, modularni pristup, hidrodinamičke značajke, energetska učinkovitost, buka, vibracije ekološka prihvatljivost]]></keywords_hr><keywords_en><![CDATA[passenger vessel, modular approach, hydrodynamic characteristics, energy efficiency, noise, vibrations, environmental impact]]></keywords_en><summary_hr><![CDATA[Svrha projekta „Zeleni modularni putnički brod za Mediteran – ZEMP“ je razvoj nove metodologije projektiranja malih putničkih brodova namijenjenih za plovidbu Mediteranskim morem primjenom modularnog pristupa. Modularni pristup omogućava promjenu proizvodne paradigme od klasičnog pristupa u kojemu se sve komponente izrađuju u brodogradilištu prema paralelnoj proizvodnji različitih modula od strane kooperanata te završnoj montaži u brodogradilištima. Predviđeno je da se putnički broj sastoji od tri modula koji će činiti trup broda, brodski energetski sustav i nadgrađe. Kombinacijom tih modula mijenjat će se karakteristike broda, kao što su dimenzije, kapacitet, propulzijske značajke, pogonsko gorivo i razne inovativne energetski učinkovite tehnologije. Dakako, ovakav pristup povećava složenost procesa projektiranja jer je već u fazi projektiranja modula potrebno uzeti u obzir mnoštvo različitih značajki kojima koncepti trebaju udovoljavati, kao i pripadajući regulatorni okvir.U sklopu projekta najprije će biti provedena analiza tržišta za razna područja plovidbe unutar Mediterana kako bi se mogle odrediti potrebe kojima putnički brodovi trebaju udovoljiti. Na temelju toga će biti predloženo nekoliko preliminarnih koncepata, dok će finalni koncepti biti razvijeni uzimajući u obzir i sve druge aspekte projektiranja: hidrodinamičke i propulzijske značajke, jednostavnost procesa izrade, razinu ugode za putnike i posadu, kao i ekološki prihvatljiva rješenja energetskog sustava. Na temelju kriterija za pojedine namjene odabrat će se optimalni koncepti malog putničkog broda. Projekt će rezultirati predloženim konceptima koji će, ovisno o potrebama tržišta, imati niže troškove proizvodnje, povećanu razinu ugode za putnike i posadu, smanjenu potrošnju goriva i smanjeni utjecaj na okoliš.]]></summary_hr><summary_en><![CDATA[The objective of the project “Green Modular Passenger Vessel for Mediterranean – GRiMM” is the development of the new design methodology for small passenger ships aimed for the operation in the Mediterranean Sea, by applying the modular concept approach. The modular concept enables the change of the ship production paradigm from the classical all-in-one approach to a parallel manufacture of different components done by highly specialized producers and a final assembly done by the local shipyard. The target vessel is considered as made of independent modules which can be combined together to achieve different characteristics in terms of ship dimensions, carrying capacity, operating conditions, fuel options and innovative energy efficient solutions. Fundamentally, the ship is made of three modules forming the ship hull, power system and superstructure. Of course this approach makes the design process much more complex than that for a single specific ship, as it has to account for all the different needs and for the associated regulatory aspects.First, an analysis of the market needs and of the corresponding ship requirements will be performed for different navigation regions in the Mediterranean Sea. Preliminary concepts based on that analysis will be proposed, while the final concepts will be developed taking into account all the aspects of ship design: hydrodynamic and propulsion efficiency, simplified manufacturing processes, ship habitability (comfort level for crew and passengers) as well as environmentally friendly energy solutions. Through this project several optimized modular passenger vessels will be proposed depending on the selected design criteria sets. In this sense it is expected that the project will result in a number of concepts depending on the market needs with reduced production costs, higher level of comfort for crew and passengers, reduced fuel consumption as well as lower environmental impact.]]></summary_en></project><project>
<id>7723</id><title_hr><![CDATA[Multimodalni prikaz molekularnih zbivanja tijekom oporavka mišjeg mozga nakon ishemijskog oštećenja]]></title_hr><title_en><![CDATA[]]></title_en><user_id>7297</user_id><user_firstLast_name>Srećko Gajović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-6297</code><acronim><![CDATA[RepairStroke]]></acronim><duration>01.10.2018 - 01.04.2023</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>25254</team_members_id><team_members_names><![CDATA[ Doktorand: Paula Josić ]]></team_members_names><keywords_hr><![CDATA[moždani udar, miš, snimanje magnetskom rezonancijom, snimanje bioluminiscencijom, upala]]></keywords_hr><keywords_en><![CDATA[stroke, mouse, magnetic resonanse imaging, bioluminescence imaging, inflammation]]></keywords_en><summary_hr><![CDATA[Moždani udar predstavlja vodeći zdravstveni problem, te postoji potreba razumijevanja mehanizma oporavka i mogućeg liječenja mozga nakon moždanog udara. Ovim projektom pokušava se razjasniti slijed zbivanja tijekom oporavka mozga primjenom multimodalnog prikaza molekularnih zbivanja u mozgu živog miša. To će se postići primjenom niza modaliteta snimanja živih miševa magnetskom rezonancijom, te pretkliničkim optičkim snimanjem bioluminiscencije. Eksperimentalnim zatvaranjem srednje moždane arterije postići će se ishemijsko oštećenje mišjeg mozga. Procesi koji će biti promatrani uključuju upalu (praćenu bioluminiscencijom Tlr2-luc transgeničnog miša), stvaranje novih nastavaka živčanih stanica (praćenu bioluminiscencijom Gap43-luc transgeničnog miša), apoptozu (praćenu zatočenim DEVD-luciferinom), poremećaj i obnovu povezanosti mozga (difuzijskim tenzornim snimanjem magnetskom rezonancijom), te obnovu perfuzije mozga (označavanjem spina u arterijama tijekom snimanja magnetskom rezonancijom) , čijom kombinacijom se očekuje uočiti kritična molekularna i stanična zbivanja koja djeluju neuroprotektivno i obnavljaju mozak. Snimanja živog miša korelirat će se s funkcionalnim i morfološkim analizama mišjeg mozga mikroskopijom i testovima ponašanja životinja. Ovim će se omogućiti definiranje parametara oporavka mozga u mišjem modelu moždanog udara kako bi se pretklinički provjerili mogući terapijski pristupi i omogućila njihova translacija u kliničke pokuse.]]></summary_hr><summary_en><![CDATA[Stroke is the leading health problem, hence a need to understand the mechanism of recovery and possible treatment of the brain dammaged by stroke. This project attempts to clarify the sequence of events during the brain recovery after ischemic lesion by using in vivo multimodal molecular imaging of the mouse brain. This will be achieved through a combination of imaging modalities including magnetic resonance imaging (MRI), and preclinical optical bioluminescence imaging (BLI). Mouse stroke model of the middle cerebral artery occlusion (MCAO) will result in the ischemic brain damage. The processes that will be monitored include inflammation (visualized by bioluminescence of TLR2-luc transgenic mouse), extension of neuronal processes (visualized by bioluminescence of GAP43-luc transgenic mouse), apoptosis (followed by caged DEVD-luciferin), brain connectivity (MR diffusion tensor imaging), and brain perfusion (MRI arterial spin labeling), which combination is expected to describe critical molecular and cellular events that act neuroprotective and regenerate brain. In vivo imaging will be correlated with functional and morphological analysis of the mouse brain using microscopy and behavioral tests. This will allow to define the preclinical parameters of recovery of the brain in a mouse model of stroke to be used to evaluate possible therapeutic approaches and enable their translation into the clinical trials.]]></summary_en></project><project>
<id>7726</id><title_hr><![CDATA[Multi-funkcionalni tkani kompoziti za toplinsku zaštitnu odjeću]]></title_hr><title_en><![CDATA[Multifunctional woven composites for thermal protective clothing]]></title_en><user_id>773</user_id><user_firstLast_name>Stana Kovačević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-3170</code><acronim><![CDATA[MF-WCOMPROTECT]]></acronim><duration>15.11.2018 - 14.11.2022</duration><status>Završio</status><financ_value>115.203,40 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Tekstilna tehnologija, </scie_field_hr><scie_field_en>Textile technology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Tekstilno-tehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Textile Technology]]></institution_en><team_members_id>4636, 4643, 23951, 24077, 24195, 19362, 5086, 864980, </team_members_id><team_members_names><![CDATA[Ivana Schwarz, Snježana Brnada, Barbara Iskerka Pavlica, Tatjana Rijavec Rijavec, Polona Dobnik Dubrovski, Beti Rogina-Car, Jacqueline Domjanic, Ana Kiš, ]]></team_members_names><keywords_hr><![CDATA[Tkani kompoziti, toplinska zaštitna odjeća, multi-funkcionalnost, višeslojne provezujuće tkanine, procesi projektiranja]]></keywords_hr><keywords_en><![CDATA[Woven composites, thermal protective clothing, multifunctionality, multilayer interlacing woven fabrics, designing processes]]></keywords_en><summary_hr><![CDATA[Tkanina predstavlja nezaobilazan element u gotovo svakoj zaštitnoj odjeći i čini važan dio mnogih zaštitnih sredstava. Na zaštitne tkanine postavljeni su brojni i visoki zahtjevi, čijim zadovoljavanjem omogućavaju zaštitu ljudskog tijela u krajnjim uvjetima primjene, gdje su prisutne najveće opasnosti od vanjskih utjecaja. Ovim projektom dat će se naglasak na proces projektiranja tkanina, što će rezultirati izradom inovativnih višeslojnih, provezujućih, dišljivih i laganih tkanina, koje će svojom strukturom nadmašiti svojstva dosadašnjih tkanina u primjeni za toplinsku zaštitnu odjeću. Njihova zaštita svojstva bazirati će se prvenstveno konstrukcijskim parametrima tkanine, ali i novim vlaknima visokih svojstava, koja će biti utkana u gornju tkaninu na licu, time pružajući svojstva određene i snažne zaštite, dok će naličje činiti lagana tkanina ugodnog opipa i prozračne strukture, koja će svojim karakteristikama povećati udobnost nošenja. Provezivanjem spomenutih dviju tkanina u postupku tkanja, dobit će se jedna kompaktna plošna tvorevina koja će imati funkciju laganog i tankog kompozita, a koji će odražavati sliku zaštitne tkanine visoke funkcionalnosti. Kompaktnost takovih materijala u fizikalno-mehaničkim svojstvima, daje im prednost u odnosu na jednoslojne tkanine i poznate kompozite, gdje je opravdano očekivanje postizanja svojstava iznimno dobre čvrstoće, trajnosti, otpornosti na habanje i relevantne vanjske uvjete, dišljivosti te udobnosti pri nošenju. Kompleksnost izrade višeslojnih provezujućih tkanina, omogućuje neograničenost u projektiranju struktura tkanina, ali istovremeno predstavlja i veliki izazov u njihovom razvoju, izradi, znanstvenim istraživanjima te primjeni. Sve navedeno upućuje na mogućnost postizanja iznimne funkcionalnosti te time i na opravdanost primjene takovih inovativnih tkanih kompozita u zaštitnoj odjeći.]]></summary_hr><summary_en><![CDATA[Fabric is an indispensable element in almost every protective article of clothing and makes an important part of many protective products. Numerous and high requirements are placed on protective fabrics. By meeting these requirements these fabrics enable the protection of the human body under extreme conditions of application where the highest risks of external influences are present. This project will focus on the fabric design process which will result in the creation of innovative, multi-layered, breathable and lightweight fabrics that will overcome the properties of the previous fabrics in the application for thermal protective clothing. Their protective properties will be based primarily on construction fabric parameters, and also on new high performance fibres that will be woven into the upper fabric on the face side, thus providing properties of specific and strong protection, while the back fabric side will be a lightweight fabric of comfortable handle and airy structure whose characteristics will enhance wear comfort. By interlacing the two mentioned fabrics in the weaving process one compact fabric will be obtained that will have the function of a lightweight and thin composite and reflect the image of a protective high performance fabric. The compactness of such materials taking account of physical-mechanical properties gives them an advantage over single-layer fabrics and well-known composites whereby it is reasonable to achieve properties of exceptionally good strength, abrasion resistance, durability and relevant external conditions, breathability and wear comfort. The complexity of making multilayer interlacing fabrics makes it possible to design fabrics without any limits, but at the same time it is a great challenge for their development, manufacture, scientific research and use. All of the above indicates the possibility of achieving the extraordinary functionality which justifies the use of these innovative woven composites in protective clothing.]]></summary_en></project><project>
<id>7727</id><title_hr><![CDATA[Mikrostrukture jugoslavenskoga socijalizma: Hrvatska 1970-1990.]]></title_hr><title_en><![CDATA[Microstructures of Yugoslav Socialism: Croatia 1970-1990]]></title_en><user_id>2955</user_id><user_firstLast_name>Igor Duda</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-5394</code><acronim><![CDATA[MICROSOCIALISM]]></acronim><duration>09.11.2018 - 08.04.2023</duration><status>Završio</status><financ_value>76.888,98 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Povijest, </scie_field_hr><scie_field_en>History, </scie_field_en><institution_hr><![CDATA[Sveučilište Jurja Dobrile u Puli]]></institution_hr><institution_en><![CDATA[Juraj Dobrila University of Pula]]></institution_en><team_members_id>5558, 7221, 19077, 4311, 24094, 23306, 865125, </team_members_id><team_members_names><![CDATA[Magdalena Najbar-Agičić, Christian Axboe Nielsen, Chiara Bonfiglioli, Anita Buhin, Saša Vejzagić, Tina Filipović, Tomislav Branđolica, ]]></team_members_names><keywords_hr><![CDATA[samoupravni socijalizam, društvene strukture, mikrohistorija, Hrvatska, povijest Jugoslavije]]></keywords_hr><keywords_en><![CDATA[self-managed socialism, social structure, microhistory, Croatia, history of Yugoslavia]]></keywords_en><summary_hr><![CDATA[Sedamdesete i osamdesete godine vrijeme su u potpunosti oblikovanoga jugoslavenskog socijalističkog sustava u kojem je samoupravljanje primijenjeno na svim razinama s namjerom odumiranja države i prepuštanja njezinih ovlasti samoupravnim zajednicama i organizacijama. Općina je bila zamišljena kao zajednica u kojoj se na mikrorazini aktiviraju sve poluge društveno-političkog ustroja. Osnovni znanstveni cilj projekta je istraživanjem društvenih odnosa i struktura u odabranim općinama dati odgovore na pitanja o funkcioniranju kasnoga socijalizma. Pozornost će biti usmjerena na ulogu građana kao samoupravljača u mjesnim zajednicama, zaštitu samoupravnih prava i društvenoga vlasništva, javnu i državnu sigurnost, lokalne medije koji stvaraju sliku o zajednici, položaj organizacija udruženog rada između ekonomije i politike, kulturno stvaralaštvo i kulturnu politiku u samoupravnim interesnim zajednicama, ulogu žene i ženskoga aktivizma te na položaj i utjecaj boraca i njihove veteranske organizacije. Poredbena analiza studija slučaja daje uvid u splet međuodnosa koji svjedoče o položaju moći, društvenoj umreženosti, stanju zajamčenih prava i sloboda, nadzoru i udovoljavanju različitim interesima. Metodološki pristup proizlazi iz perspektive društvene, kulturne, političke i ekonomske povijesti, povijesti svakodnevice i mentaliteta te povezivanja pogleda odozdo i odozgo, horizontalne i vertikalne komunikacije, odnosno mikropovijesti s makropovijesnim okvirom. Rezultati će biti objavljeni kao znanstvena monografija, zbornik radova i još dvadesetak izvornih znanstvenih radova.]]></summary_hr><summary_en><![CDATA[The 1970s and 1980s were a time in which the Yugoslav socialist system was fully formed, and during which self-management was implemented at all levels, in order for the state to wither away and to leave its powers to self-managed communities and organizations. The municipality was envisioned as a small community in which all the levels of the general socio-political organization were established, only on a microscale. The main academic aim of the project is to unravel the functioning of late socialism through an investigation of social relations and structures in selected municipalities. The project will focus on the role of citizens as self-managers in local communities, on the protection of self-management rights and social property, on public and state security, on local media in charge of creating an image of the community, on the position of organizations of associated labour between economics and politics, on cultural creativity and cultural politics in self-managed communities of interests, on the role of women and women&#39;s activism, and on the position and influence of veterans and their organization. A comparative analysis of case studies will shed light on the interplay of relationships that provide insights into issues such as power relations, social networking, the status of guaranteed rights and freedoms, as well as surveillance and compliance with different interests. The methodological approach will rely on social, cultural, political and economic history, the history of everyday life and the history of mentality. It will also establish connections between perspectives from below and perspective from above, as well as between horizontal and vertical communication, connecting microhistory with a macro-historical framework. The research results will be presented through an academic monograph, an edited volume and another twenty academic papers based on original research.]]></summary_en></project><project>
<id>7731</id><title_hr><![CDATA[Eksperimentalna platforma za simulaciju endovaskularnog liječenja intrakranijskih aneurizmi]]></title_hr><title_en><![CDATA[Experimental Platform for Simulation of Endovascular Treatment of Intracranial Aneurysms]]></title_en><user_id>7650</user_id><user_firstLast_name>David Ozretić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-3796</code><acronim><![CDATA[ElPlaSTICA]]></acronim><duration>10.05.2019 - 01.11.2023</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Clinical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>24130, 1010, 20210, 1012, 28647, 865301, 865237, </team_members_id><team_members_names><![CDATA[Ivan Jovanović, Igor Karšaj, Damir Godec, Lana Virag, Toni Škugor, Philipp Milović, Mislav Tujmer, ]]></team_members_names><keywords_hr><![CDATA[intrakranijska aneurizma, endovaskularno liječenje, potpornica za preusmjeravanje protoka, metamaterijal, 3D ispis, inverzni problem]]></keywords_hr><keywords_en><![CDATA[intracranial aneurysm, endovascular treatment, flow diverter stent, metamaterial, 3D printing, inverse problem]]></keywords_en><summary_hr><![CDATA[Potpornice za preusmjeravanje protoka postale su nedavno novi način liječenja intrakranijskih aneurizmi. Takve potpornice usmjeruju krv mimo otvora aneurizme i smanjuju utok, s ciljem izazivanja hemostaze unutar njenog lumena i, u konačnici, njene okluzije. Još uvijek nije razjašnjeno zašto takvo liječenje u nekim slučajevima dovodi do potpune okluzije, dok u drugim aneurizma ostaje otvorena ili čak raste i rupturira. Brojna istraživanja smatraju kako je promjena u hemodinamici izazvana ugrađenom potpornicom odgovorna kako za razvoj okluzije, tako i rupture. Ovaj projekt nastoji donijeti nove spoznaje o hemodinamici intrakranijske aneurizme i arterije na kojoj se nalazi. Glavni cilj projekta je proučiti karakteristike protoka u aneurizmi prije i nakon ugradnje potpornice za preusmjeravanje protoka, i preslikati te karakteristike na eksperimentalnu platformu. Središnji dio platforme bit će realistična 3D ispisana replika aneurizme, stvorena na temelju podataka bolesnika i razvijena da bude realistična i po pitanju geometrije i mehaničkog ponašanja. Nakon uspješne validacije, eksperimentalna platforma mogla bi služiti za planiranje, pripremu i uvježbavanje endovaskularnog liječenja intrakranijskih aneurizmi.]]></summary_hr><summary_en><![CDATA[In recent years, flow diverter stents have emerged as a new way of treating intracranial aneurysms. A flow diverter stent diverts blood flow past the aneurysm opening and reduces inflow with the intent of causing hemostasis inside its lumen and, eventually, occlusion of the aneurysm. It is yet unclear why in some cases the treatment leads to complete occlusion, while in other cases the aneurysm stays open or even grows and ruptures. In many studies the change in hemodynamics induced by flow diverter is considered as main factor, both for promoting occlusion and rupture. This project aims to bring new insights into hemodynamics of intracranial aneurysm and its parent artery. The main goal of the project is to study the flow conditions in an aneurysm before and after the treatment with a flow diverter, and to replicate that conditions in an experimental platform. Central part of the platform will be a realistic 3D printed replica of an aneurysm, created from patient data and developed to be realistic both in terms of geometry and mechanical behaviour. Upon successful validation, experimental platform could be used for planning, preparation and training of endovascular treatment of intracranial aneurysms.]]></summary_en></project><project>
<id>7732</id><title_hr><![CDATA[Homogenizacija, redukcija dimenzije i strukturalna optimizacija u mehanici kontinuuma]]></title_hr><title_en><![CDATA[Homogenization, dimension reduction and structural optimization in continuum mechanics]]></title_en><user_id>6764</user_id><user_firstLast_name>Igor  Velčić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-8904</code><acronim><![CDATA[Homdirestroptcm]]></acronim><duration>06.11.2018 - 05.11.2022</duration><status>Završio</status><financ_value>69.104,39 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>23610, 23580, 23626, 23619, 20370, 349, 23775, 23783, 23578, 23191, 864987, </team_members_id><team_members_names><![CDATA[Paolo Piovano, Elisa Davoli, Mikhail Cherdantsev, Kirill Cherednichenko, Marin Bužančić, Krešimir Burazin, Ivana Crnjac, Jelena Jankov, Antonio Gaudiello, Josip Žubrinić, Pedro Luis Hernandez Llanos, ]]></team_members_names><keywords_hr><![CDATA[homogenizacija, redukcija dimenzije, strukturalna optimizacija, elastičnost, elasto-plastičnost, feromagnetizam, veliki contrast, kristalizacija]]></keywords_hr><keywords_en><![CDATA[homogenization, dimension reduction, structural optimization, elasticity, elasto-plasticity, ferromagnetism, high-contrast, crystallization]]></keywords_en><summary_hr><![CDATA[Mješovite i tanke strukture su posvuda oko nas. Primjeri se protežu od industrijski proizvedenih dijelova materijala pa sve do bioloških tkiva. Općenito se ovakvi materijali u svojoj prirodi bitno razlikuju i podvrgnuti su različitim tipovima vanjskih utjecaja. U slučaju kad materijal oscilira na maloj skali ili je zamjetno tanji u jednom ili dva smjera (ili kombinacija tih dvaju svojstava) teško je numerički tretirati pripadne parcijalne diferencijalne jednadžbe. U tim slučajevima se identificira jedan ili nekoliko malih parametara, koji predstavljaju skalu na kojoj materijal oscilira ili odnos duljine i debljine objekta, te se izvodi efektivni model kad se ti parametri puštaju ka nuli. Očekuje se da su tako dobiveni modeli jednostavniji sa analitičke i numeričke strane. Asimptotička analiza diferencijalnih jednadžbi s brzo oscilirajućim koeficijentima ili sa singularitetima koji su posljedice tankoće domene je bila predmet interesa primjenjenih analitičara tijekom zadnjih pola stoljeća. Razumijevanje i kvantificiranje ponašanja heterogenih i tankih materijala je sljedeći prirodan korak u općem napretku znanosti materijala, širenja valova i matematičke fizike.  Ovisno o prirodi oscilacija koje mogu biti periodičke, ergodične ili općenite, materijali se analiziraju metodama dvoskalne konvergencije, stohastičke dvoskalne konvergencije, metodama kompenziranr kompaktnosti te varijacijskim računom. Od posebnog su interesa mješavine u velikom kontrasta (smjese materijala s suprotnim svojstvima) koje tvore metamaterijal čiji spektar ima isprekidanu strukturu. Matematički alati kojima se pristupa ovakvim problemima uključuju teoriju operatora, varijacijski račun, vjerojatnosne metode, H-konvergenciju i H-mjere.]]></summary_hr><summary_en><![CDATA[Composite and thin structures are everywhere around us. The examples go from industrially produced pieces of materials to biological tissues. In general, these kind of materials have different nature and are exposed to different kind of external loads. Usually when the material oscillates on a small scale or is significantly thinner in one or two directions (or the combination of both properties) it is difficult to treat the appropriate partial differential equations numerically. In these cases one usually identifies one or more small parameters, being the scale on which material oscillates or the relation between the width and length of the object, and then looks for the effective model when these parameters go to zero. The obtained models are expected to be simpler both from the analytical and numerical point of view. Asymptotic analysis of differential equations with rapidly oscillating coefficients or with singularities that emerge from the thickness of the domain has featured prominently among the interests of the applied analysis community during the last half a century. The problem of understanding and quantifying the overall behaviour of heterogeneous or thin media has emerged as a natural step within the general progress of material science, wave propagation and mathematical physics. The nature of the oscillations of the material can be assumed to be periodic, ergodic or completely general and thus analysed by two-scale convergence method, stochastic two-scale convergence, compensated compactness approach or calculus of variations. The special interest arises in high-contrast composites (mixtures of materials with opposite properties) where one obtains a metamaterial with a band gap structure of the spectrum. The mathematical tools to deal with these kind of problems include operator theory, calculus of variation, probability, H-convergence, H-measure. ]]></summary_en></project><project>
<id>7737</id><title_hr><![CDATA[Analiza problema interakcije fluida i strukture i primjene]]></title_hr><title_en><![CDATA[Analysis of fluid-structure interaction problems and applications]]></title_en><user_id>5074</user_id><user_firstLast_name>Boris Muha</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-3706</code><acronim><![CDATA[FSIApp]]></acronim><duration>01.11.2018 - 15.01.2023</duration><status>Završio</status><financ_value>130.051,76 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>24025, 17761, 23677, 23758, 23697, 628, </team_members_id><team_members_names><![CDATA[Suncica Canic, Marija Galić, Petar Kunštek, Sarka Necasova, Ana Radošević, Marko Vrdoljak, ]]></team_members_names><keywords_hr><![CDATA[Interakcija fluida i struktura, Generalizirana rješenja, Slabo-jaka jedinstvenost, Navier-Stokesove jednadžbe, Derivacija oblika, Numeričke metode]]></keywords_hr><keywords_en><![CDATA[Fluid-structure interaction, Generalized solutions, Weak-strong uniqueness,  Navier-Stokes equations,  Shape derivative, Numerical method for PDEs]]></keywords_en><summary_hr><![CDATA[Problemi interakcije fluida i struktura (FSI problemi) opisuju dinamiku multifizikalnog sustava koji uključuje tekuće i krute/elastične komponente. Oni su svakodnevna pojava u prirodi i pojavljuju se u raznim primjenama, od biomedicine do inženjerstva. Matematički, FSI problemi su nelinearni sustavi parcijalnih diferencijalnih jednadžbi mješovitog hiperboličkog-paraboličnog tipa sa slobodnom granicom. Tok fluida opisuju 3D Navier-Stokesove jednadžbe, dok je struktura modelirana jednadžbama 3D nelinearne elastodinamike ili s nekim nižedimenzionalnim modelom (npr. Koiterova ljuska). Unatoč svojoj važnosti u primjenama i velikoj istraživačkoj aktivnosti u području FSI problema tijekom proteklih desetljeća, zbog složenosti problema čak i osnovna pitanja kao što su postojanje rješenja i dalje su otvorena u općem slučaju. Naš prvi cilj je konstrukcija slabih i rješenja koje poprimaju vrijednost u mjerama za FSI probleme koji uključuju nelinearne modele za strukturu. Drugo, proučavat ćemo jedinstvenost konstruiranih rješenja. Točnije, dokazat ćemo rezultate tipa „slabo-jake“ jedinstvenosti za razne FSI modele. Naši treći i četvrti ciljevi motivirani su primjenama u biomedicini i inženjeringu. Nastavit ćemo razvijati tehnike derivacije oblika u kontekstu FSI problema i koristiti ga za proučavanje FSI problema optimalnog upravljanja.Razni pojednostavljeni i reducirani FSI modeli često se koriste u inženjerskoj i matematičkoj literaturi, npr. FSI s linearno elastičnom ljuskom povezanom preko rubnih slip/no-slip uvjeta i jednadžba tankog sloja. Naš je cilj rigorozno izvesti i analizirati ove modele, počevši od općeg FSI modela (3D fluid povezan s 3D strukturom).Važnost FSI problema u primjenama zahtijeva dizajn i implementaciju učinkovitih numeričkih shema. Te će se sheme temeljiti na našoj teorijskoj analizi, koju planiramo upotpuniti odgovarajućom analizom konvergencije.]]></summary_hr><summary_en><![CDATA[Fluid-structure interaction (FSI) problems describe the dynamics of a multiphysics system involving fluid and solid components. They are everyday phenomena in nature and arise in various applications ranging from biomedicine to engineering. Mathematically, FSI problems are non-linear systems of partial differential equations of mixed hyperbolic-parabolic type with a moving boundary. The fluid flow is typically governed by the 3D Navier-Stokes equations, while the structure is modelled by the equations of 3D non-linear elastodynamics or with some lower dimensional model (e.g. Kotier shell). Despite its importance in applications and large research activity in the FSI area during last decades, due to the complexity of the problem, even the basic questions like the existence of solutions are still open in the general case.  Our first objective is to construct global in time weak or measure valued solutions to the FSI problems involving nonlinear models for the structure. Secondly, we will study uniqueness properties of the constructed solutions. More precisely, our goal is to prove the results of weak-strong uniqueness type for various FSI models.Our third and fourth goals are motivated by applications in biomedicine and engineering. We will further develop shape derivative techniques in the context of FSI problems and use it to study FSI optimal control problems. Various simplified and reduced FSI models are extensively used in engineering and mathematical literature, e.g. FSI with linearly elastic shells coupled via slip/no-slip boundary condition and sixth-order thin-film equations. Our goal is to rigorously derive and analyze these models, starting from the general FSI model (3D fluid coupled with 3D structure). High applicational relevance of the considered problems demands design and implementation of efficient numerical schemes. These schemes will be based on our theoretical analysis, which we plan to enhance with the corresponding convergence analysis. ]]></summary_en></project><project>
<id>7738</id><title_hr><![CDATA[Pametne hibridne tehnike hlađenja silicijskih fotonaponskih panela ]]></title_hr><title_en><![CDATA[Smart hybrid cooling techniques for siliceous photovoltaic panels]]></title_en><user_id>860</user_id><user_firstLast_name>Sandro Nižetić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-2814</code><acronim><![CDATA[SMART-PV-COOL]]></acronim><duration>05.11.2018 - 04.11.2022</duration><status>Završio</status><financ_value>89.030,46 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Temeljne tehničke znanosti, Strojarstvo, </scie_field_hr><scie_field_en>Basic engineering sciences, Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Fakultet elektrotehnike, strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Electrical Engineering, Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>2623, 2698, 23797, 23796, 23808, 25442, </team_members_id><team_members_names><![CDATA[Duje Čoko, Filip Grubišić Čabo, Müslüm Arici, Agis Papadopoulos, EFFROSYNI GIAMA, Mišo Jurčević, ]]></team_members_names><keywords_hr><![CDATA[fotonaponi,tehnike hlađenja,učinkovitost,eksperiment,obnovljivi izvori energije]]></keywords_hr><keywords_en><![CDATA[photovoltaics,cooling techniques,efficiency,experimental approach,renewable energy sources]]></keywords_en><summary_hr><![CDATA[Ukupna proizvodnja električne energije iz fotonaponskih (FN)  tehnologija trenutno prema podatku iz 2016. pokriva oko 2% globalnih svjetskih potreba za električnom energijom pri čemu je u svijetu instalirano preko 300 GW. Na tržištu su najzastupljenije silicijske fotonaponske tehnologije (94%) i to u formi poly ili mono fotonaponskih panela od čega se danas najviše proizvode polikristalni (poly) silicijski paneli. Iako se znatni napori ulažu u razvoj novih fotonaponskih tehnologija, trenutne novo razvijene FN tehnologije su ipak u ranoj fazi razvoja, tj laboratorijskih istraživanja, te su ekonomski svakako nekoknuretne sa silicijskim FN tehnologijama. Stoga, razumno je za očekivati kako će upravo i u narednim dekadama biti tržišno najzastupljenije silicijske FN tehnologije.  Jedan od ključnih nedostataka silicijskih FN tehnologija je pored relativno visoke investicije, zatim skromne ukupne učinkovitosti je upravo je i problem degradacije učinkovitosti fotonaponske energetske konverzije porastom radne temperature FN panela. Za postojeće silicijske FN tehnologije prosječna degradacija učinkovitost iznosi od 0.4%/°C od 0.6%/°C, odnosno kod vršnih radnih temperatura FN panela ukupna degradacija performansi kreće se od 10% do 15% . Nadalje, prema najnovijim istraživanjima snižavanje radne temperature FN panela utječe povoljno i na povećanje životnog vijeka istog (prema nekim autorima i preko 40 god., dok je primjerice za postojeće silicijske tehnologije deklarirani životni vijek uobičajeno 25 godina). Glavni cilj predloženog projekta je razviti i testirati dvije hibridne tehnike hlađenja koje će imati realiziran sustav pametne regulacije, čime će se u sušitni kombinirati po potrebi pasivna te aktivna tehnika hlađenja u cilju maksimizacije radnih perfomansi (iz toga razloga hibridni pristup). U konačnici cilj je povećanje učinkovitosti komercijalno dostupnih silicijskih FN tehnologija kao i povećanja trajnosti istih.]]></summary_hr><summary_en><![CDATA[According to the data from 2016, the overall electricity production from the photovoltaic (PV) technologies covers about 2% of the global world electricity demands, with currently installed around 300 GW of the PV capacities. Currently, the highest market share is related to the siliceous (Si) based FN technologies (94% in 2016) and majority of the produced PVs are in the multi-crystalline form (Si-poly), and the rest are in the mono-crystalline form. Although, the intense research efforts are focused on the development of the novel PV technologies, still they are in the early stage development (laboratory investigations usually), and in any case they can’t compete with the SI-based PV technologies with respect to the economic aspect. One of the main issues related to the PV technologies is degradation of the photovoltaic energy conversion efficiency due to elevated operating temperature of the PV panels. Existing PV technologies have an average efficiency degradation rate from 0.4%/°C to 0.6%/°C, i.e. performance drop can be expected from about 10% to 15% (where the most intense efficiency degradation is in the case of the multi-crystalline PV panels). Application of the proper cooling technique for the PVs can reduce PV panel operating temperature and by that can ensure increase in the produced electricity from the PV system. Furthermore, according to the latest research findings the benefit of the cooling techniques is also increase in the PV panel lifetime (from usually 25 years to over 40 years). The main goal of the herein proposed project is to develop (and test by experimental way) the two specific hybrid cooling techniques for PVs that will have ensured smart regulation system (which will enable combination both of the passive and cooling techniques as well as optimization of the operation time). Final project goal is to ensure increase in the efficiency of the market available siliceous PV technologies as well as their lifetime. ]]></summary_en></project><project>
<id>7741</id><title_hr><![CDATA[Europski korijeni moderne Hrvatske: transfer ideja na političkom i kulturnom polju u 18. i 19. stoljeću ]]></title_hr><title_en><![CDATA[European Origins of Modern Croatia: Transfer of Ideas on Political and Cultural Field in 18th an 19th centuriesd ]]></title_en><user_id>1526</user_id><user_firstLast_name>Vlasta Švoger</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-2539</code><acronim><![CDATA[EuKor]]></acronim><duration>19.10.2018 - 18.10.2023</duration><status>Završio</status><financ_value>51.111,55 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Povijest, </scie_field_hr><scie_field_en>History, </scie_field_en><institution_hr><![CDATA[Hrvatski institut za povijest]]></institution_hr><institution_en><![CDATA[Croatian Institute of History]]></institution_en><team_members_id>23980, 1124, 23635, 23728, 4836, 23415, 19523, 23699, 232, 4458, </team_members_id><team_members_names><![CDATA[Jasna Turkalj, Teodora Shek Brnardić, Mirela Krešić, Štefka Batinić, Branko Ostajmer, Marijan Šabić, Marina  Protrka Štimec, Zrinko Novosel, Ivana Horbec, Dinko Župan, ]]></team_members_names><keywords_hr><![CDATA[Hrvatska, (proto)modernizacija, transfer ideja, europski utjecaji, 18. i 19. stoljeće, intelektualna povijest, povijest institucija]]></keywords_hr><keywords_en><![CDATA[Croatia, (proto)modernisation, transfer of ideas, European influences, 18th and 19th centuries, intellectual history, history of institutions]]></keywords_en><summary_hr><![CDATA[Polazeći od hipoteze da su temelji za izgradnju Hrvatske kao moderne države postavljeni tijekom 18. i „dugog“ 19. stoljeća cilj projekta je istražiti transfer i recepciju različitih ideja i idejnih strujanja europske provenijencije u političkom i kulturnom životu Hrvatske koje su pridonijele oblikovanju europskog identiteta Hrvatske i njezinom preoblikovanju u modernu državu. Istraživanja će polaziti od rubnog geopolitičkog položaja hrvatskih zemalja koji je stoljećima bilo sjecište putova i civilizacijskih okvira - mediteranskog, zapadnoeuropskog i euroazijskog - i analizirat će na koji je način on utjecao na transfer političkih i kulturnih ideja iz drugih europskih zemalja. Istraživanjem će se nastojati rekonstruirati korelacije između novih europskih ideja i hrvatskih tradicionalnih političkih i kulturnih obrazaca. Propitivat će se europski idejni utjecaji na razvoj parlamentarnog sustava i parlamentarne kulture u Hrvatskoj, na postavljanje temelja moderne javne uprave, javnozdravstvenog sustava i školstva te na transfer ideja na području privatnog prava i književnosti. Istraživat će se i veze istaknutih europskih intelektualaca s nekim uglednim hrvatskim političkim i kulturnim djelatnicima. Istraživanje će se temeljiti na komparativnoj metodi i studijama slučaja (case studies) koje će se interpretirati primjenom teorije kulturnog transfera i drugih translacijskih teorija. Projekt će rezultirati nizom znanstvenih radova u međunarodno indeksiranom časopisima i zbornicima, dvjema e-knjigama i digitalnim repozitorijem koji će biti javno dostupni na mrežnoj stranici projekta te organiziranjem nekoliko znanstvenih kolokvija uz sudjelovanje relevantnih inozemnih i domaćih stručnjaka. ]]></summary_hr><summary_en><![CDATA[Proceeding from a hypothesis that the foundations of Croatia as a modern state were laid in the 18th and “long” 19th centuries, the objective of the project is to research into the transfer and reception of various ideas and the influence of ideas of European provenance in Croatia’s political and cultural life, which contributed to the shaping of Croatia’s European identity and its transformation into a modern state. The research will proceed from the peripheral location of Croatian Lands, which has been for centuries at the junction of ways and at the boundary of different civilisations – Mediterranean, West European, and Euro-Asian. Moreover, it will analyse in what way this location influenced the transfer of political and cultural ideas from other European countries. The researches will primarily focus on the analysis of the correlations between new European ideas and traditional Croatian political and cultural patterns. The influence of European ideas will be questioned on development of parliamentary system and culture in Croatia, on laying foundations for modern public administration, public health care system and school system, and on transfer of ideas in private law and literature. The object of the analysis will also be links between distinguished European intellectuals and some reputable Croatian political and cultural figures. The research will be based on the comparative method and case studies, which will be interpreted applying the theory of cultural transfer and other translation theories. The project will result in a sizeable number of scientific papers in internationally indexed journals and in edited books, two e-books and a digital repository publicly accessible at the project’s web-site, as well as in organisation of several scientific colloquia with the participation of relevant foreign and domestic experts.]]></summary_en></project><project>
<id>7746</id><title_hr><![CDATA[Funkcija novo-otkrivenog proteina u mozgu, urogvanilina, od stanične fiziologije do ljudskog zdravlja]]></title_hr><title_en><![CDATA[The Function of URoguanylin, a New protein in the brAin, from the CEll physiology to human health]]></title_en><user_id>5255</user_id><user_firstLast_name>Aleksandra Dugandžić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-7416</code><acronim><![CDATA[FURNACE/FURNACE]]></acronim><duration>01.12.2018 - 30.11.2022</duration><status>Završio</status><financ_value>131.328,92 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, Clinical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>12975, 4921, 4936, 4667, 19503, 23467, 23436, 23688, 23596, 24159, 23598, 28893, </team_members_id><team_members_names><![CDATA[Nikola Habek, Vladiana Crljen, Vesna Lukinović-Škudar, Spomenka Ljubić, Milan Kordić, Martina Tkalčić, Petar Škavić, Margarita Berkopić, Ante Piljac, Nada Pjevač, Pero Bubalo, Domagoj Prebeg, ]]></team_members_names><keywords_hr><![CDATA[elektrofiziološka istraživanja, hipotalamus, smeđe masno tkivo, klinička istraživanja, infracrvena termografija]]></keywords_hr><keywords_en><![CDATA[patch clamp, hypothalamus, brown adipose tissue, clinical studies, infrared thermography]]></keywords_en><summary_hr><![CDATA[Diabetes mellitus tipa 2 (T2DM) i komplikacije veliki su teret za današnje čovječanstvo. Komplikacije ove bolesti koje nastaju zbog hiperglikemije godišnje uzrokuju smrt oko 3,4 milijuna ljudi u svijetu. Novi pristup ovom problemu bio bi porast potrošnje glukoze putem aktivacije smeđeg masnog tkiva (BAT) putem regulacije središnjim živčanim sustavom. BAT pretvara glukozu nakon obroka u toplinu. Nedavno smo otkrili novi protein u mozgu, urogvanilin (UGN), čiji izražaj se mijenja nakon unosa hrane te promjene u njegovoj funkciji u mozgu mijenja aktivnost BAT-a. Cilj ovog projekta je odrediti funkciju UGN-a u mozgu i njegovu ulogu u fiziologiji BAT-a. To će biti istraženo na staničnoj razini (elektrofiziološka istraživanja), na životinjskom modelu te na zdravoj i T2DM populaciji. Specifični ciljevi ovog projekta su odrediti: mehanizam djelovanja UGN-a u hipotalamusu, regulacija stvaranja UGN-a u mozgu i promjene volumena i aktivnosti BAT-a nakon produljene primjene UGN-a. Usporedit ćemo ulogu UGN-a u regulaciji aktivnosti BAT-a kod oboljelih od T2DM i zdravih ispitanika mjerenjem aktivnosti BAT-a nakon obroka. Ta aktivnost biti će uspoređena s promjenama u homeostazi glukoze i sintezom inzulina, glukagonu sličnog peptida-1 (GLP-1) i UGN-a. Moguć utjecaj dobi, spola i tjelesne težine na moždane učinke UGN-a biti će određeni procjenom izražaja njegovog receptora u različitim regijama ljudskog mozga. Aktivnost BAT-a nakon obroka biti će određena jednostavnom, neinvazivnom, ali dovoljno osjetljivom infracrvenom termografijom. Svi pokusi biti će izvedeni na oba spola zbog toga što postoje velike razlike u metabolizmu glukoze između muškaraca i žena koje još nisu u potpunosti razjašnjene. Ovo istraživanje moglo bi dovesti do novog pristupa liječenju hiperglikemije kod oboljelih od T2DM koje bi poboljšalo metabolizam glukoze, smanjilo komplikacije dijabetesa, odgodilo terapiju inzulinom, smanjilo troškove liječenja te sveukupno unaprijedilo kvalitetu života oboljelih od T2DM.]]></summary_hr><summary_en><![CDATA[Type 2 Diabetes mellitus (T2DM) and its complications are great burden for humanity today. Diabetic complications due to hyperglycaemia cause death to about 3.4 million people worldwide yearly. A new approach to maintain glucose homeostasis in T2DM patients is to increase the glucose consumption by an activation of brown adipose tissue (BAT) via central nervous system. BAT converts glucose to heat after a meal. Recently, we discovered a new protein in the brain, uroguanylin (UGN), which expression is regulated by food intake and its brain function changes BAT activity. The goal of our project is to determine the function of UGN in the brain and its role on BAT physiology. They will be investigated at cellular level (electrophysiological research), animal model and in healthy and T2DM human population. The specific aims of this study are: to determine mechanism of UGN action in the hypothalamus, regulation of UGN synthesis in the brain, BAT volume and activity after prolonged UGN administration. The importance of UGN in regulation of BAT function in humans will be established by measuring of BAT activity after a meal and compared to glucose homeostasis and production of insulin, glucagon-like peptide-1, and UGN. The possible influence of age, gender and body weight on brain UGN effects will be determined by estimation of expression of UGN receptor in different human brain regions. BAT activity after a meal will be determined by simple non-invasive but more sensitive infrared thermography. All experiments will be performed in both genders, since there is a huge difference in glucose metabolism in male and female patients which are still not explained. This study could lead to development of a new approach in treatment of hyperglycaemia in T2DM patients, which will improve glucose metabolism, decrease diabetic complications, postpone insulin application, decrease medical expenses and overall improve the quality of life of patients with T2DM.]]></summary_en></project><project>
<id>7747</id><title_hr><![CDATA[Povećanje energetske učinkovitosti izmjenjivača topline]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5302</user_id><user_firstLast_name>Anica Trp</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-9661</code><acronim><![CDATA[HEXENER]]></acronim><duration>11.10.2018 - 10.10.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, </scie_field_hr><scie_field_en>Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Tehnički fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Engineering]]></institution_en><team_members_id>25384</team_members_id><team_members_names><![CDATA[ Doktorand: Josip Batista ]]></team_members_names><keywords_hr><![CDATA[energetska učinkovitost, lamelni izmjenjivači topline, latentni spremnik topline, obnovljivi izvori energije, numeričke simulacije, eksperiment]]></keywords_hr><keywords_en><![CDATA[energy efficiency, fin and tube heat exchanger, latent heat storage, renewable energy sources, numerical simulations, experiment]]></keywords_en><summary_hr><![CDATA[Predmet istraživanja projekta je povećanje energetske učinkovitosti izmjenjivača topline. Istraživanja će biti usmjerena na analizu izmjene topline i povećanja energetske učinkovitosti lamelnih izmjenjivača topline te latentnog spremnika topline kao posebnog tipa izmjenjivača. Znanstveno-istraživački ciljevi projekta usmjereni su na produbljivanje znanstvenih spoznaja u području izmjenjivača topline te obuhvaćaju: numeričko i eksperimentalno istraživanje utjecaja geometrijskih karakteristika i pogonskih uvjeta izmjenjivača topline na fizikalni proces izmjene topline i učinkovitost, numeričko i eksperimentalno istraživanje utjecaja pogonskih uvjeta, geometrije i karakteristika akumulatora topline na izmjenu topline i učinkovitost latentnih spremnika te istraživanje pohrane energije u sustavu obnovljivih izvora energije s latentnim spremnikom.U okviru projekta nabavit će se i instalirati eksperimentalna oprema potrebna za provođenje eksperimentalnog dijela istraživanja. U svrhu provedbe numeričkih analiza, za svaki od problema istraživanja, definirat će se domena numeričkog proračuna, postaviti matematički model, odabrati numerička metoda i provesti numeričko rješavanje. Postavljeni matematički i računalni modeli bit će provjereni usporedbom rezultata s rezultatima eksperimentalnog istraživanja. Nakon provjere valjanosti, provest će se nizovi numeričkih simulacija u svrhu ispitivanja utjecaja različitih geometrijskih karakteristika i pogonskih uvjeta lamelnih izmjenjivača topline, kao i utjecaja pogonskih uvjeta, geometrije i karakteristika akumulatora topline latentnog spremnika na izmjenu topline i učinkovitost. Provest će se računalna analiza sustava obnovljivih izvora energije s latentnim spremnikom topline, za različite pogonske uvjete i dimenzije komponenata sustava. Očekivani rezultati i znanstveni doprinos obuhvaćaju proširenje postojećih znanstvenih spoznaja i prijedlog mjera za poboljšanje u svrhu povećanja energetske učinkovitosti izmjenjivača topline.]]></summary_hr><summary_en><![CDATA[The research topic of the project is the enhancement of the heat exchanger energy efficiency. Investigations will focus on the analysis of heat transfer and energy efficiency enhancement of the fin and tube heat exchanger and the latent heat storage as special type of heat exchanger.Scientific research objectives of the project are focused on enlarging of scientific knowledge in field of heat exchangers and include: numerical and experimental research of influence of heat exchanger geometry characteristics and operating conditions, as well as influence of latent heat storage operating conditions, geometry and phase change material characteristics on heat transfer and efficiency. Also, energy storing in system of renewable energy sources with latent heat storage will be studied.Experimental equipment, needed to carry out experimental part of the research, will be acquired and installed as part of the project. For purposes of numerical analysis, for each problem, domain for numerical calculation will be defined, mathematical model will be set up, numerical method will be chosen and numerical calculations will be performed. The established mathematical and computer models will be validated by comparing results with the results of experiments. After validation, series of numerical simulations will be carried out to investigate influence of different geometry characteristics and operating conditions of the fin and tube heat exchangers, as well as effects of operating conditions, geometry and characteristics of phase change material on heat transfer and efficiency of latent heat storage. Computational analysis of renewable energy system with latent heat storage, for different operating conditions and dimensions of system components, will be carried out.Expected results and scientific contributions include the enlarging of existing scientific knowledge and proposal of measures for improvement in order to enhance the heat exchanger energy efficiency.]]></summary_en></project><project>
<id>7748</id><title_hr><![CDATA[Hidrotermalna sinteza dopiranog cerij oksidnog nanokatalizatora]]></title_hr><title_en><![CDATA[Hydrothermal synthesis of doped ceria nanocatalyst]]></title_en><user_id>2766</user_id><user_firstLast_name>Stanislav Kurajica</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-2963</code><acronim><![CDATA[HOuDiNI]]></acronim><duration>01.11.2018 - 31.10.2022</duration><status>Završio</status><financ_value>63.043,33 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Temeljne tehničke znanosti, Kemijsko inženjerstvo, </scie_field_hr><scie_field_en>Basic engineering sciences, Chemical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet kemijskog inženjerstva i tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Chemical Engineering and Technology]]></institution_en><team_members_id>1333, 1517, 23982, 6813, 28679, </team_members_id><team_members_names><![CDATA[Juraj Šipušić, Gordana Matijašić, Katarina Mužina, Marina Duplančić, Ivana Katarina Munda, ]]></team_members_names><keywords_hr><![CDATA[cerijev oksid, hidrotermalna sinteza, dopanti, katalitička aktivnost, termička stabilnost]]></keywords_hr><keywords_en><![CDATA[ceria, hydrothermal synthesis, dopants, catalytic activity, thermal stability]]></keywords_en><summary_hr><![CDATA[Hidrotermalnom sintezom bit će pripravljene dopirane nanočestice cerijeva oksida namijenjene uporabi kao heterogeni katalizator za uklanjanje hlapivih organskih spojeva. Ključna značajka cerijeva oksida je njegova sposobnost reverzibilnog redoks procesa čime se omogućava stvaranje vakancija kisika, velika pokretljivost kisika i kapacitet skladištenja kisika unutar kristalne rešetke. Takva svojstva čine cerijev oksid široko korištenim heterogenim katalizatorom.Jedna od metoda sinteze nanočestica cerijeva oksida je hidrotermalna sinteza budući da posjeduje brojne prednosti kao što su jednostavnost, dostupnost i ekološka neškodljivost te omogućuje pripremu nanočestica visoke čistoće, željene veličine, morfologije i velike površine.Uvođenje defekata u kristalnu rešetku cerijeva oksida ugradnjom metalnih iona daje cerijevom oksidu poboljšana svojstva. Stoga će se provesti sustavna studija uzoraka cerijeva oksida dopiranog ionima prijelaznih metala (Mn, Fe, Co, Ni, Cu i Zn) priravljenih pomoću hidrotermalne sinteze, kako bi se istražila sposobnost prijelaznih metala da uđu u kristalnu rešetku cerijeva oksida u uvjetima hidrotermalne sinteze, toplinska stabilnost pripremljenih katalizatora i njihova katalitička aktivnost u procesu oksidacije modelnog spoja. Na temelju dobivenih rezultata odabrat će se dva dopanta, najvjerojatnije bakar i mangan, a cerijev oksid dopiran ovim elementima bit će temeljito istražen. Pored strukture, mikrostrukture, fizikalnih svojstava i katalitičke aktivnosti, posebna pozornost bit će posvećena stabilizaciji veličine kristala i specifične površine cerijeva oksida pri povišenim temperaturama. Istraživanje će omogućiti stjecanje novih znanja o dopiranom cerijevom oksidu pripremljenom hidrotermalnom sintezom. Dodatno, očekuju se značajni rezultati na području kinetike rasta zrna i uporabe kinetičke analize za procjenu stabilnosti veličine kristala i specifične površine nanokatalizatora na povišenim temperaturama.]]></summary_hr><summary_en><![CDATA[Doped ceria nanoparticles, aimed to be used as heterogeneous catalyst for elimination of volatile organic compounds, will be prepared using hydrothermal synthesis.A key feature of ceria is its capability of reversible redox process enabling the creation of oxygen vacancies, high oxygen mobility and oxygen storage capacity within the crystal lattice. Such properties make ceria extensively used as heterogeneous catalysts. One of the synthesis methods of choice for the preparation of ceria nanoparticles is the hydrothermal synthesis, since it possesses numerous advantages such as simplicity, affordability and environmental benignity, and it enables the preparation of high purity nanoparticles of desired size, morphology and large surface area. The introduction of defects by incorporation of metal ions into ceria crystal lattice yields with enhanced properties of ceria. Therefore a systematic study of transition metals (Mn, Fe, Co, Ni, Cu i Zn) doped ceria prepared using the hydrothermal synthesis will be conducted in order to investigate the ability of transition metals to enter the ceria crystal lattice under hydrothermal synthesis conditions, thermal stability of prepared catalysts, and their catalytic activity for oxidation of model compound. On the basis of obtained results two dopant elements, most probably copper and manganese, will be selected and ceria doped with these elements should be thoroughly investigated. Beside structure, microstructure, physical properties and catalytic activity, special attention will be paid to the stabilization of crystal size and specific surface area of ceria under elevated temperatures. The investigation will enable the gain of new knowledge on doped ceria prepared by hydrothermal synthesis. Additionally, significant results are expected in the area of grain growth kinetics and its use for the estimation of nanocatalyst crystal size and specific surface area stability at elevated temperatures. ]]></summary_en></project><project>
<id>7749</id><title_hr><![CDATA[Kontrola neurodegeneracije moduliranjem sprege između upale i proteinopatije]]></title_hr><title_en><![CDATA[Controlling neurodegeneration by modulating the crosstalk between inflammation and proteinopathy]]></title_en><user_id>4630</user_id><user_firstLast_name>Ivana Munitić </user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-8563</code><acronim><![CDATA[ImmunoModifyCNS]]></acronim><duration>25.03.2019 - 24.09.2023</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Fakultet biotehnologije i razvoja lijekova]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Biotechnology and Drug Development]]></institution_en><team_members_id>5326, 20286, 12500, 5775, 604, 6264, 20580, 28721, 861732, </team_members_id><team_members_names><![CDATA[Miranda Mladinić Pejatović, Jasna Križ, Andrea Markovinović, Hrvoje Jakovac, Marin Dominović, Jonathan Ashwell, Emanuele Buratti, Nikolina Prtenjača, Josip Peradinović, ]]></team_members_names><keywords_hr><![CDATA[neuroinflamacija, neurodegeneracija, optineurin, TBK1, IFN-beta]]></keywords_hr><keywords_en><![CDATA[neuroinflammation, neurodegeneration,  optineurin, TBK1, IFN-beta]]></keywords_en><summary_hr><![CDATA[Dva obilježja zajednička svim neurodegenerativnim bolestima su kronična neuroinflammacija i proteinopatija, procesi koji se aktivno međusobno amplificiraju. Mutacije u optineurinu, adaptorskom proteinu koji regulira različite stanične funkcije poput prijenosa signala tijekom upale i autofagije, pronađene su u amiotrofičnoj lateralnoj sklerozi (ALS) i frontotemporalnoj demenciji (FTD). Da bismo istražili ulogu optineurina u neurodegeneraciji prilikom ALS/FTD-a, razvili smo mišji model u kojem smo izrezali regiju kojom veže ubiquitin, time oponašajući C-terminalne delecije pronađene u bolesnika. Zanimljivo je da su u bolesnika s ALS-om i FTD-om nedavno pronađene mutacije i u proteinskim partnerima optineurina, poput Tank binding kinaze 1 (TBK1), što sugerira da djeluju u zajedničkom neuroprotektivnom putu. Ovdje ćemo pratiti dva ključna opažanja iz naše početne karakterizacije modela Optn470T gdje smo ustanovili da nedostatak funkcionalnog optineurina umanjuje aktivnost TBK1 i produkciju IFN-ß u stanicama mikroglije i makrofaga, dovodeći do neravnoteže u proupalnim i protuupalnim čimbenicima, te da su ostarjeli Optn470T miševi razvijaju patognomonične ALS/FTD agregate u frontalnom korteksu, koji sadrže TDP-43 i ubikvitin. U ovom projektu planiramo 1) primijeniti nove CRISPR modele stanične deficijencije optineurina kako bismo razjasnili spregu između agregacije proteina i upale in vitro, te  2) manipulirati tijek bolesti u in vivo ALS/FTD modelu odabranim genetskim i virusnim metodama. Nadalje, na temelju naših rezultata da je optineurin ključni regulator imunomodulacijskog IFN-ß citokina, posebna pažnja će biti stavljena na pokušaj terapijskog apliciranja IFN-ß intratekalno pomoću genske terapije s AAV 2/9. Budući da je optineurin neuroprotektivna molekula na raskrižju upale i proteinopatije, nadamo se da ćemo točnim molekularnim razjašnjenjem njengove neuroprotektivne uloge, identificirati najprikladnije putove za terapijsku manipulaciju.]]></summary_hr><summary_en><![CDATA[Two hallmarks common to all neurodegenerative diseases are chronic neuroinflammation and proteinopathy, processes that actively amplify each other. Mutations in optineurin, an adaptor protein implicated in various cellular functions including inflammatory signalling and autophagy, have been found in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). To investigate the mechanistic role of optineurin in neurodegeneration in ALS/FTD, we have generated a mouse model in which the ubiquitin-binding region of optineurin was deleted, mimicking C-terminal truncations found in patients. Interestingly, optineurin-interacting proteins, such as Tank binding kinase 1 (TBK1), have also recently been found in ALS and FTD patients, suggesting that they participate in a shared neuroprotective pathway. Here we will follow-up two key observations from our initial characterization of the Optn470T model where we found that the lack of functional optineurin precluded optimal TBK1 activation and IFN-ß production in microglia and macrophages, leading to a disbalance in proinflammatory and anti-inflammatory factors, and that aged Optn470T mice developed pathognomonic ALS/FTD aggregates containing TDP-43 and ubiquitin in their frontal cortices. To this end, we will 1) apply novel CRISPR-generated cellular systems of optineurin deficiency to elucidate the crosstalk between protein aggregation and inflammation in vitro, and 2) manipulate the disease course in the in vivo ALS/FTD models by selected genetic and viral tools. In particular, based on our results that optineurin is a key regulator of the immunomodulatory IFN-ß pathway, a special focus will be to deliver IFN-ß intrathecally by adenovirus-associated virus 2/9 gene therapy. Overall, by addressing several outstanding questions on optineurin, a neuroprotective molecule at the crossroads of inflammation and proteinopathy, we intend to pinpoint the most likely pathway(s) for therapeutic manipulation.]]></summary_en></project><project>
<id>7750</id><title_hr><![CDATA[Marine robotics research infrastructure network (EUMarineRobots)]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5244</user_id><user_firstLast_name>Stjepan Bogdan</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-6042</code><acronim><![CDATA[]]></acronim><duration>01.11.2018 - 01.09.2021</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Temeljne tehničke znanosti, </scie_field_hr><scie_field_en>Basic engineering sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>25385</team_members_id><team_members_names><![CDATA[ Doktorand: Barbara Arbanas ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>7751</id><title_hr><![CDATA[Teorijske pretpostavke molekularne biologije]]></title_hr><title_en><![CDATA[Theoretical Underpinnings of Molecular Biology]]></title_en><user_id>4704</user_id><user_firstLast_name>Predrag Šustar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-3378</code><acronim><![CDATA[ThUMB]]></acronim><duration>01.11.2018 - 31.10.2022</duration><status>Završio</status><financ_value>88.150,63 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filozofija, Interdisciplinarne humanističke znanosti, </scie_field_hr><scie_field_en>Philosophy, Interdisciplinary humanities, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Filozofski fakultet u Rijeci]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>3788, 23599, 598, 24063, 24064, 24065, 23826, 26521, 6074, 864837, 856122, </team_members_id><team_members_names><![CDATA[Zdenka Brzović, James DiFrisco, Tomislav Domazet-Lošo,  Pierdaniele Giaretta, Philip Kitcher, Telmo Pievani, Thomas Reydon, Vito Balorda, Martina Blečić, Zvonimir Anić, Aleksandar Božić, ]]></team_members_names><keywords_hr><![CDATA[Gen, funkcija, prirodna selekcija, znanstveno objašnjenje, društvena spoznajna teorija, evolucija genoma, evo. očuvana područja, mehanizam, zakoni]]></keywords_hr><keywords_en><![CDATA[Gene, function, natural selection, scientific explanation, social epistemology, genome evolution, evolutionary conserved regions, mechanism, laws]]></keywords_en><summary_hr><![CDATA[Istražujemo načine utjecaja suvremene molekularne biologije na razumijevanje ključnih pojmova evolucijske biologije. Utjecaj možemo promatrati ne samo u projektima tzv. &#39;velike znanosti&#39; (big-science), prije svega, Projektu ljudskog genoma, odnosno nastavnim projektima, npr. ENCODE (ENCyclopedia Of Dna Elements), već i u mnogim projektima tzv. &#39;male znanosti&#39; (small-science). U središtu projekta bit će odnos dviju spomenutih bioloških domena – molekularne i evolucijske biologije, koji u području istraživanja (PI) filozofije biologije nije u dovoljnoj mjeri sustavno razmatran (usp., iznimno, Sarkar (2015); Doolittle (1984)).Struktura projekta je sljedeća: u prvome (1) dijelu ispitujemo kako visoko sofisticirana otkrića unutar eukariotskog genoma navode na ponovno razmatranje odgovarajućih teoretskih pojmova kao što su gen, biološka funkcija i prirodna selekcija. Ponajprije, otkrića koja se tiču mehanizma genske duplikacije, gene-sharing i mehanizama povezanih s visokim udjelom tzv. &#39;mobilne DNA&#39; te recentnih otkrića novih funkcionalnih gena u ne-kodirajućim genomskim područjima. Sva navedena otkrića zahtijevaju značajne promjene na pojmovnoj razini. Stoga želimo pokazati kako tri spomenuta ključna pojma – gen, biološka funkcija i prirodna selekcija – nisu samo povezana s dotokom novih empirijskih informacija, već su međusobno isprepletena i na teoretskoj razini. To također utječe na funkcioniranje znanstvene prakse, odnosno na znanstveno zaključivanje.U drugome (2) dijelu projekta, usredotočujemo se na različite vrste znanstvenog objašnjenja u području evolucije genoma. Naše je gledište da treba transformirati prevladavajuću mehanicističku teoriju objašnjenja, integrirajući strukturalne i etiološke vrste znanstvenog objašnjenja.Konačno, u trećem (3) dijelu, koristeći recentne znanstvene studije/analize slučaja (case-studies), istražujemo način na koji znanstvene odluke i rezultati utječu na šire javno razumijevanje funkcioniranja znanosti o živim sustavima.]]></summary_hr><summary_en><![CDATA[In this project, we examine the ways in which contemporary molecular biology is influencing the understanding of some of the key-notions in evolutionary biology. The influence in question can be traced not only in ‘big-science’ projects, most notably, the Human Genome Project (HGP) and its follow-ups, e.g., the Encyclopedia of DNA Elements (ENCODE), but also in many ‘small-science’ research projects. In that regard, we focus on the exchange between these two main biological domains as a less explored layer in philosophy of biology. Accordingly, our project is structured as follows: in Part 1, we examine how discoveries of intricate workings within eukaryotic genomes, in particular, the human genome, have clearly suggested to rethink the corresponding more theoretical notions of a gene, biological function and natural selection. Namely, the discoveries concerned with the mechanisms of gene duplication and gene sharing, then, extremely large portions of mobile DNA elements within eukaryotic genomes and, for instance, new functional genes arising from non-coding regions, all call for significant accommodations at the corresponding conceptual level. The notion of gene is closely associated with the notion of biological function, which, depending on the account endorsed, can be defined with reference to natural selection. Accordingly, we show how these three notions are theoretically intertwined in many interesting ways, which also influence scientific practice. In Part 2 of the project, we single out distinct types of explanatory practices in the area of genome evolution. We claim that, in this regard, we should overcome the standard view of mechanistic explanation and adopt an appropriate level of explanatory integration between structural and etiological explanations. Finally, in Part 3, through some recent case-studies, we explore how scientific decision-making and dissemination of scientific results relate to the public understanding of the life sciences.]]></summary_en></project><project>
<id>7754</id><title_hr><![CDATA[Mehanizmi nutrijentom posredovanih učinaka endogenog glukagonu sličnog peptida-1 na kognitivne i metaboličke poremećaje u eksperimentalnim modelima neurodegenerativnih bolesti]]></title_hr><title_en><![CDATA[Mechanisms of nutrient-mediated effects of endogenous glucagone-like peptide -1 on cognitive and metabolic alterations in experimental models of neurodegenerative disorders]]></title_en><user_id>1198</user_id><user_firstLast_name>Melita Šalković-Petrišić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-8938</code><acronim><![CDATA[NutrientGLP-1]]></acronim><duration>01.12.2018 - 28.02.2023</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>3079, 1191, 22452, 27148, 861481, </team_members_id><team_members_names><![CDATA[Jelena  Osmanović Barilar, Ana Knezović, Ana Babić, Jan Homolak, Davor Virag, ]]></team_members_names><keywords_hr><![CDATA[glukagonu sličan peptid-1, galaktoza, Alzheimerova bolest, Parkinsonova bolest, streptozotocin, 6-OHDA, kognitivne funkcije]]></keywords_hr><keywords_en><![CDATA[glucagone-like peptide -1, galactose, Alzheimer disease, Parkinson disease, streptozotocin, 6-OHDA, cognition]]></keywords_en><summary_hr><![CDATA[Projekt nastavlja prethodna istraživanja učinaka oralne galaktoze u eksperimentalnoj Alzheimerovoj bolesti (AB) putem detaljne karakterizacije mehanizama terapijskog učinka paralelno u eksperimentalnoj AB i Parkinsonovoj bolesti (PB). Rezultati aktualnog projekta podupiru naše preliminarne rezultate i upućuju da oralne galaktoza ublažava/normalizira kognitivna oštećenja u ranoj patološkoj fazi eksperimentalne sporadične AB (sAB) izazvane intracerebroventrikularnom primjenom streptozotocina u štakora (STZ-icv model). Ovo istraživanje će objediniti dva nova terapijska pristupa u liječenju neurodegenerativnih bolesti, temeljena na glukagonu-sličnom peptidu-1 (GLP-1) i nutrijentima. U netransgeničnim, toksinom izazvanim štakorskim modelima (sAB/STZ-icv model, PB/6-hidroksidopamin, 6-OHDA model) istražit će se učinak endogenog GLP-1 posredovan primjenom oralne galaktoze/nutrijenta. Cilj ovog 4-godišnjeg projekta je ispitati jesu li akutni metabolički/neuroprotektivni učinci jedne doze oralne galaktoze u sAB modelu posredovani samo endogenim GLP-1 ili/i endogenim glukoza-ovisnim inzulinotropnim peptidom (GIP). Također, cilj je ispitati je li terapijski potencijal dugotrajne primjene oralne galaktoze na kognitivna oštećenja, metaboličke i neuropatološke poremećaje u sAB i PB modelima povezan primarno s kompleksnim učincima galaktoze (izravni + inkretinima posredovani učinci) ili se radi samo o inkretinom posredovanim učincima. U 5 akutnih+5 kroničnih pokusa ispitat će se kognitivne i motorne funkcije, te poremećaji homeostaze glukoze/inzulina, te glavna neuropatološka sAB/PB obilježja i parametri signalizacije GLP-1/GIP/inzulina. Projekt će donijeti nove spoznaje i razviti specifični oblik modela-načina liječenja koji nalikuje mogućoj etiopatogenezi ovih bolesti u stvarnom životu.  Rezultati će pridonijeti pojašnjenju terapijskog pristupa sAB/PB temeljenog na GLP-1 lijekovima, a očekivane publikacije povećati kompetitivnost mladih istraživača za buduće projektne prijave. ]]></summary_hr><summary_en><![CDATA[This project aims to continue previous research on oral galactose treatment in experimental Alzheimer’s disease (AD) by in parallel characterizing in depth mechanisms of its therapeutic activity in experimental AD and Parkinson disease (PD). The results of on-going research supported our preliminary data and demonstrated that in the streptozotocin (STZicv)-induced rat model of sAD, oral galactose ameliorates or normalizes cognitive impairment in the early stage of sAD pathology.  By combining glucagon-like peptide-1 (GLP-1)-related and nutrient-based trends in accomplishing desirable neuroprotective effects in the treatment of neurodegenerative disorder, this research will explore oral galactose (nutrient)-promoted activity of endogenous GLP-1 in non-transgenic rat models of toxin-induced sporadic AD (sAD/STZ-icv model) and PD (6-hydroxydopamine, 6-OHDA model). This 4-year project aims to explore whether acute metabolic/neuroprotective effects of a single oral galactose dose in sAD model are mediated by promotion of solely endogenous GLP-1 or/and by endogenous glucose-dependent insulinotropic peptide (GIP), and whether the therapeutic potential of chronic oral galactose treatment on cognitive deficits, metabolic dysfunction and neuropathology in STZ-icv and 6-OHDA models results primarily from the complex galactose-induced effects (direct + incretin-mediated ones) or it is solely the incretin-mediated effect. Cognitive and motor performance and glucose/insulin homeostasis will be explored in 5 acute and 5 chronic experiments accompanied by AD-/PD-neuropathological hallmarks as well as GLP-1/GIP/insulin signalling assessment.  Project will gain new knowledge and establish the specific model-treatment design that mimics more closely the real life situation. The results will contribute to elucidation of GLP-1-based therapeutic approach in AD/PD treatment. Expected publications will increase competitiveness of young researches in future grant applications.]]></summary_en></project><project>
<id>7755</id><title_hr><![CDATA[Seizmička izolacija osnove građevine s uporabom prirodnih materijala - testiranje s potresnom platformom i numeričko modeliranje]]></title_hr><title_en><![CDATA[]]></title_en><user_id>12821</user_id><user_firstLast_name>Jure Radnić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-3575</code><acronim><![CDATA[BASEISOLATION]]></acronim><duration>17.08.2018 - 17.08.2021</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Građevinarstvo, </scie_field_hr><scie_field_en>Civil engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu Fakultet građevinarstva, arhitekture i geodezije]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Civil Engineering, Architecture and Geodesy]]></institution_en><team_members_id>19464</team_members_id><team_members_names><![CDATA[ Doktorand: Ivan Banović ]]></team_members_names><keywords_hr><![CDATA[Seizmička izolacija baze, aseizmički sloj, prirodni materijal, kameni oblutci, potresna platforma, numerički model]]></keywords_hr><keywords_en><![CDATA[Seismic base isolation, aseismic layer, natural material, pebbles, shake table, numerical model]]></keywords_en><summary_hr><![CDATA[Primarni cilj projekta je kreiranje i eksperimentalna provjera inovativnog koncepta za smanjenje potresnih sila na niže i srednje visoke građevine pomoću aseizmičkog sloja od prirodnih materijala ispod temelja. Predviđena su dva rješenja takvog sloja. Nakana je da takav koncept bude dostatno efikasan, racionalan i jednostavan za realizaciju, te da nađe svoju široku praktičnu primjenu. Najprije bi se eksperimentalno testirala efikasnost predviđenih aseizmičkih slojeva, varirajući više njihovih tehničko - tehnoloških parametara, s ciljem da se na građevinu prenesu što manja potresna ubrzanja (sile). Prvi aseizmički sloj je predviđen samo iz prirodnih kamenih oblutaka, a drugi od prirodnih kamenih oblutaka u kombinaciji s tankim slojem „kliznog“ materijala. Potom bi se eksperimentalno ispitalo ponašanje zgrada s prethodno navedenim aseizmičkim slojevima pri različitim potresima. Koristio bi se pojednostavljeni umanjeni modeli zgrada koji dobro simuliraju njihove dinamičke karakteristike. Testirala bi se četiri jednostupnjevna modela različite krutosti, simlirajući ponašanje građevina različite krutosti. Isti modeli zgrada bi se testirali i za slučaj bez aseizmičkog sloja, kako bi se mogla provjeriti efikasnost predviđene seizmičke izolacije.Ako bi rezultati istraživanja potvrdili očekivanja, predloženi koncept seizmičke izolacije imao bi slijedeće prednosti u odnosu na uobičajenu seizmičku izolaciju pomoću diskretnih, tehnički složenih i skupih naprava: racionalnost, jednostavnost, trajnost, proširenje tržišta, prihvatljivost za siromašnije zemlje i sl.Jedan od ciljeva projekta je razvoj numeričkog modela za pouzdanu seizmičku analizu ravninskih konstrukcija s predviđenom aseizmičkom izolacijom, kao i prijedlog jednostavnih inženjerskih izraza za proračun kapaciteta posmične nosivosti i deformabilnosti aseizmičkog sloja.Smatra se da bi uspješna realizacija predloženog projekta dala vrijedan doprinos razvoju znanosti i prakse u predmetnom području.]]></summary_hr><summary_en><![CDATA[The primary objective of the project is creation and experimental verification of an innovative concept for reducing seismic forces acting on buildings by using aseismic layer made of natural materials below foundation. Two solutions of such layer are planned. The intention is to make an efficient, rational and easy-to-implement concept, with its wide practical application. First, the effectiveness of the planned aseismic layers would be experimentally tested on the model of a rigid building, by varying several their technical - technological parameters, in order to transfer seismic acceleration (force) on the building as less as possible. The first aseismic layer is predicted as consisted only of natural stone pebbles, and the other of the natural stone pebbles in combination with a thin layer of a &#39;&#39;sliding&#39;&#39; material. Afterwards, the behaviour of real buildings with the above mentioned non-seismic layers would be experimentally tested under different earthquakes. Simplified reduced models of buildings that simulate their dynamic characteristics well would be used. Four one-degree models with different stiffness would be tested. If the results of the study would confirm expectations, the proposed concept of seismic isolation would have the following advantages compared to conventional seismic isolation using discrete, technically complex and expensive systems: rationality, simplicity, sustainability, market expansion, eligibility for poorer countries, etc. One of the objectives of the project is the development of numerical models for reliable seismic analysis of planar structures with the planned seismic isolation, as well as the proposal of simple engineering expressions for the calculation of the shear strength capacity and deformability of the aseismic layer. It is believed that the successful implementation of the proposed project would provide a valuable contribution to the development of science and practice in the concerned area. ]]></summary_en></project><project>
<id>7761</id><title_hr><![CDATA[NK stanice u patogenezi kongenitalne infekcije citomegalovirusom]]></title_hr><title_en><![CDATA[NK cells in pathogenesis of congenital cytomegalovirus infection]]></title_en><user_id>4834</user_id><user_firstLast_name>Ilija Brizić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-4435</code><acronim><![CDATA[NKconCMV]]></acronim><duration>01.12.2018 - 31.03.2023</duration><status>Završio</status><financ_value>131.862,76 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Medicine]]></institution_en><team_members_id>4682, 24014, 19694, 4652, 5357, 4999, 28652, 865130, </team_members_id><team_members_names><![CDATA[Vanda Juranić Lisnić, Ester Pernjak Pugel, Jelena Tomac, Berislav Lisnić, Daria Kveštak, Đurđica Cekinović Grbeša, Carmen Rožmanić, Jelena Materljan, ]]></team_members_names><keywords_hr><![CDATA[citomegalovirus, kongenitalna infekcija, NK stanice, iscrpljenost NK stanica, Eomes]]></keywords_hr><keywords_en><![CDATA[cytomegalovirus, congenital infection, NK cells, NK cell exhaustion, Eomes]]></keywords_en><summary_hr><![CDATA[Kongenitalna infekcija humanim citomegalovirusom (HCMV) najčešći je virusni uzročnik razvojnih i funkcijskih poremećaja živčanog sustava, kao što su mentalna retardacija, mikrocefalija i senzori neuralnog oštećenja sluha. S obzirom da je HCMV specifičan za vrstu u istraživanjima kongenitalne infekcije se koristi model infekcije miševa s mišjim citomegalovirusom (MCMV). U mnogim razvojnim aspektima novookoćeni su miševi ekvivalentni ljudskom fetusu u drugom trimestru trudnoće, što je i vrijeme kada najčešće dolazi do infekcije HCMV-om u trudnoći. NK stanice su važne za kontrolu infekcije citomegalovirusom (CMV), a nedavno je pokazano da tijekom infekcije CMV-om NK stanice pokazuju i karakteristike stečene imunosti. Međutim, utjecaj kongenitalne CMV infekcije na imunološka svojstva NK stanica i dalje je uvelike nepoznat. Kako bi odredili utjecaj kongenitalne infekcije citomegalovirusom na NK stanice, inficirat ćemo novookoćene miševe MCMV-om i pratiti sazrijevanje i funkcionalnost NK stanica. Naši preliminarni rezultati ukazuju da infekcija MCMV-om snažno utječe na sazrijevanje NK stanica, te potiče iscrpljivanje NK stanica karakterizirano smanjenjem izražaja transkripcijskog faktora Eomesa. Cilj ovog projekta je karakterizirati funkcionalne, fenotipske i transkripcijske promjene NK stanica uzrokovane perinatalnom MCMV infekcijom. Nadalje, cilj je odrediti čimbenike i mehanizme koji potiču iscrpljivanje NK stanica, te odrediti mogu li se procesi iscrpljivanja NK stanica spriječiti ili ispraviti. Ujedno, ovim projektom će se odrediti uloga NK stanica u kontroli virusa, te nastanku patologije uzrokovane infekcijom novookoćenih miševa. Predloženo istraživanje će značajno pridonijeti razumijevanju patogeneze kongenitalne infekcije citomegalovirusom, ali i boljem razumijevanju biologije NK stanica, a napose u patološkim uvjetima. ]]></summary_hr><summary_en><![CDATA[Congenital human cytomegalovirus (HCMV) infection is the most common viral cause of long-term neurodevelopmental sequelae, including mental retardation, microcephaly and sensorineural hearing loss. As HCMV does not cross species barrier, we employ a mouse model in which newborn mice are infected with mouse cytomegalovirus (MCMV) to study congenital cytomegalovirus (CMV) infection. In many aspects newborn mice are developmentally equivalent to the human fetus during 2nd trimester of gestation, a time period when HCMV infection in humans is most frequently acquired during pregnancy. NK cells play an important role in control of CMV infection, and adaptive features of NK cells in response to CMV infection are recently being increasingly recognized. However, the extent to which congenital CMV infection affects and shapes NK-cell mediated immunity is largely unknown. To address this issue, we will use MCMV infected newborn mice and follow the impact of infection on the maturation and functional properties of NK cells. Our preliminary results indicate that MCMV infection strongly affects the maturation of NK cells and induces NK cell exhaustion characterized by downregulation of transcription factor Eomes. The goal of this project is to characterize functional, phenotypic and transcriptional changes in NK cells following perinatal MCMV infection. Furthermore, the goal is to characterize the factors and mechanisms that induce NK cell exhaustion and to determine if NK cell exhaustion can be prevented or reverted. In addition, in the proposed study we will determine the role of NK cells in MCMV control and virus induced pathology in newborn mice. The proposed research is an important step towards better understanding of pathogenesis of congenital CMV infection, but will as well contribute to better understanding of NK cell biology in general, and especially in pathological conditions.]]></summary_en></project><project>
<id>7762</id><title_hr><![CDATA[Sustav potpore odlučivanju za zeleniju i sigurniju plovidbu brodova]]></title_hr><title_en><![CDATA[DEcision Support System for green and safE ship RouTing]]></title_en><user_id>4256</user_id><user_firstLast_name>Jasna Prpić-Oršić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-3739</code><acronim><![CDATA[DESSERT]]></acronim><duration>15.01.2019 - 14.06.2023</duration><status>Završio</status><financ_value>131.793,75 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Brodogradnja, Računarstvo, Strojarstvo, Tehnologija prometa i transport, </scie_field_hr><scie_field_en>Naval architecture, Computer sciences, Mechnical engineering, Transport technology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Tehnički fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Engineering]]></institution_en><team_members_id>2951, 5403, 23653, 24206, 3868, 19041, 21407, 24213, 4179, 24204, 25744, 858448, 859450, 865636, </team_members_id><team_members_names><![CDATA[Marko Valčić, Igor Rudan, Srđan Žuškin, Vedran Mrzljak, Tomislav Mrakovčić, Natalija Vitali, Jonatan Lerga, Luca Braidotti, Duško Pavletić, Kenji Sasa, Denis Selimović, Ivan Sulovsky, Francesco Mauro, Marijana Balas, ]]></team_members_names><keywords_hr><![CDATA[sustav potpore odlučivanju, pomorstvenost, spektar valova, optimizacija rute, mjerenje, emisija stakleničkih plinova]]></keywords_hr><keywords_en><![CDATA[decision support system, seakeeping, wave spestra, route optimisation, measurements, greenhouse gases emissions]]></keywords_en><summary_hr><![CDATA[Cilj istraživanja u okviru projekta Sustav potpore odlučivanju za zeleniju i sigurniju plovidbu brodova (DESSERT) je razvoj učinkovitog sustava potpore odlučivanju (Decision Support System - DSS) kapetanima broda, kao i zapovjednicima stroja, a koji bi doprinio ”zelenijoj” i sigurnijoj plovidbi brodova. Krajnji učinak takvog DSS bilo bi svođenje ljudske pogreške na što manju mjeru, odnosno pružanje odgovornim osobama na brodu maksimalno vjerodostojne podatke i smjernice tijekom plovidbe kako bi se smanjilo onečišćenje okoliša i kako bi ljudi i teret bili što sigurniji. Istraživanja vezana uz razvoj DSS-a odvijat će se u dva osnovna smjera: energetski učinkovitija plovidba uz smanjenje emisije stakleničkih plinova; i povećanje sigurnosti plovidbe s aspekta izbjegavanja sudara i s aspekta pravovremenih reakcija u slučaju naplavljivanja broda.U okviru istraživanja planira se osmišljavanje, provedba i analiza upitnika (anketa) koji su namijenjeni kapetanima i upraviteljima stroja na brodovima. Namjera je dobivanje što vjerodostojnijih podataka o reakciji posade na pojedine dinamičke učinke uzrokovane pogoršanjem vremenskih uvjeta. Analizom anketa planira se dobiti povratne podatke o kriterijima i graničnim vrijednostima kriterija koji su mjerodavni za namjernu promjenu brzine ili kursa zbog pretjeranog njihanja broda na valovima, te razviti model “virtualnog kapetana” koji bi se koristio prilikom simulacije i planiranja rute plovidbe. Značajan znanstveni doprinos istraživanja vezan je za brodska pogonska postrojenja. Cilj je razviti sustav potpore odlučivanju na brodu uzimajući u obzir projektantsku, strojarsku i pomorsku ekspertizu u cilju stvaranja sigurnog i ekološki učinkovitog ili &#39;&#39;zelenijeg&#39;&#39; broda i plovidbe. Projektni tim sastoji se od znanstvenika koji su stručnjaci u brodogradnji, strojarstvu,  pomorskom inženjerstvu i računarstvu koji omogućuju multidisciplinarno rješavanje ovog problema.]]></summary_hr><summary_en><![CDATA[The goal of the research in a frame of project DEcision Support System for green and safE ship RouTing – DESSERT is the development of an effective Decision Support System (DSS) is planned for ship captains as well as machine commanders, which would contribute to &#39;&#39;greener&#39;&#39; and safer navigation of ships. The ultimate impact of such a DSS would be to make human error as small as possible, or to provide responsible persons on board the most credible data and guidance during navigation to reduce environmental pollution and make people and cargo safer.Research related to the development of DSS will take place in two main directions: energy-efficient navigation along with reduction of greenhouse gas emissions; and increase sailing safety by collision avoidance as well as from timely reactions in the event of flooding. Within the scope of the survey, the design, implementation and analysis of questionnaires (surveys) designed for captains and engineers on ships are planned. The intention is to get the most credible data on the crew response to the individual dynamic effects caused by the worsening of weather conditions. Survey analysis is designed to get feedback on the criteria and limit values of the criteria that are relevant to deliberate speed or course change due to excessive ship motions on waves, and to develop a &#39;&#39;virtual captain&#39;&#39; model to be used when simulating and planning the navigation route. Significant scientific contribution to research is related to ship propulsion plants. The objective is to develop decision support system on board taking into accounts the environmental issue, creating a so called safe and eco-efficient or “green” ship. The project team consists of the scientists who are experts in the naval architecture, mechanical engineering, marine engineering field and computational sciences which allow solving this problem multidisciplinary.]]></summary_en></project><project>
<id>7764</id><title_hr><![CDATA[Genetsko poboljšanje i optimizacija potencijala rodnosti pšenice]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1259</user_id><user_firstLast_name>Karolina Vrandečić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-5965</code><acronim><![CDATA[GI OPTI WHEAT]]></acronim><duration>24.10.2018 - 24.12.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Fakultet agrobiotehničkih znanosti Osijek]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Agrobiotechnical Sciences in Osijek]]></institution_en><team_members_id>25332</team_members_id><team_members_names><![CDATA[ Doktorand: Magdalena Matić ]]></team_members_names><keywords_hr><![CDATA[pšenica, urod, kvaliteta, zrno, dušik, Fusarium,  ]]></keywords_hr><keywords_en><![CDATA[wheat, yield, quality, grain, nitrogen, Fusarium, ]]></keywords_en><summary_hr><![CDATA[Današnji i budući zahtjevi za pšenicom u svijetu zahtijevaju korištenje niza novih pristupa u povećanju prinosa pšenice kako u svijetu tako i u regiji. Najizravnije i najočitije rješenje za ove izazove je kroz povećanje produktivnosti usvajanjem germplazme pšenice povećanog genetskog potencijala rodnosti i adaptabilnosti u različitim proizvodnim uvjetima. Prema tome, glavni ciljevi ovog projektnog prijedloga su: 1. fenotipizacija i karakterizacija elitne germplazme pšenice iz regije za najvažnija agronomska svojstva i svojstva kvalitete, svojstva vezanih uz NUE (nitrogen use efficiency), te tolerantnosti na najvažnije biotske stresove kao što je fuzarijska palež klasa u različitim proizvodnim uvjetima i režimu dušične gnojidbe, 2. genotipizirati odabranu germplazmu pšenice na poznate funkcionalne markere, 3. ponuditi ideotip pšenice kako bi pomogli oplemenjivačima pšenice da odaberu roditelje i optimiziraju svojstva pšenice kroz selekcijski proces ciljajući područje jugoistočne Europe, 4. razviti strategiju prema modelu temeljenom na analizi interakciji genotip*okolina (GEI) koja će povećati učinkovitost programa oplemenjivanja pšenice, i 5. identificirati superiorne genotipove pšenice koji će se koristiti u razvoju mapirajućih  i oplemenjivačkih populacija za buduća istraživanja i oplemenjivački  rad kako bi se osigurala buduća dobit od oplemenjivanja i gospodarska korist za proizvođače pšenice u Hrvatskoj. Nadamo se da će ovaj inovativni i integracijski pristup u istraživanju pšenici rezultirati objavom radova visoke kvalitete, novom nacionalnom istraživačkom platformom za pšenicu i da će povećati konkurentnost i sudjelovanje u od EU financiranim istraživačkim projektima.]]></summary_hr><summary_en><![CDATA[Current and future demands for world wheat production and security require the  exploitation of a suite of novel  approaches to increase both regional and worldwide wheat yields. The most direct and obvious solution to these challenges will be to increase productivity through the adoption of wheat germplasm with improved genetic potential and adaptability to diverse growing conditions. Thus the main objectives of this project proposal include: 1. phenotyping and characterizing elite wheat germplasm from the region for the most important agronomic and quality traits, nitrogen use efficiency (NUE) related traits, and tolerance to main biotic stresses such as Fusarium head blight under different growing conditions and regimes of nitrogen, 2. genotyping selected wheat germplasm using functional markers, 3. identification of wheat ideotypes to help breeders to select parents and optimize wheat traits through selection process targeting South-Eastern European region, 4. development of a modeling strategy for GEI analysis that will help to increase the efficiency of a plant breeding program and 5.  Identification of superior wheat genotypes that will be used to develop mapping and breeding populations for future research and breeding purposes in order to ensure future genetic gains in wheat improvement and economic benefits to farmers community in Croatia.This innovative and integrative approach to wheat research will result in high-quality research papers, a newl national wheat research platform and increased  competitiveness and participation in EU funded research projects.]]></summary_en></project><project>
<id>7765</id><title_hr><![CDATA[Inflammation and Hearing Loss Following Congenital CMV Infection]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4958</user_id><user_firstLast_name>Astrid Krmpotić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-8958</code><acronim><![CDATA[]]></acronim><duration>21.09.2018 - 21.09.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Medicine]]></institution_en><team_members_id>25389</team_members_id><team_members_names><![CDATA[ Doktorand: Marko Šustić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>7766</id><title_hr><![CDATA[Phylogeography and evolution of three ecologically divergent amphi-Adriatic plant groups]]></title_hr><title_en><![CDATA[]]></title_en><user_id>13550</user_id><user_firstLast_name>Ivana Rešetnik</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-9304</code><acronim><![CDATA[]]></acronim><duration>23.10.2018 - 31.12.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>25313</team_members_id><team_members_names><![CDATA[ Doktorand: Ana Terlević ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>7767</id><title_hr><![CDATA[Napredna simulacija samoobnavljajućih kompozita]]></title_hr><title_en><![CDATA[Advanced Composite Selfhealing Simulation]]></title_en><user_id>12906</user_id><user_firstLast_name>Ivica Smojver</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-2248</code><acronim><![CDATA[ACCESS]]></acronim><duration>28.09.2018 - 27.02.2023</duration><status>Završio</status><financ_value>108.388,08 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Zrakoplovstvo, raketna i svemirska tehnika, Strojarstvo, </scie_field_hr><scie_field_en>Aerospace, missile and space engineering, Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>1245, 602, 13620, 20217, 28693, </team_members_id><team_members_names><![CDATA[Tomislav Filetin, Tatjana Haramina, Darko Ivančević, Daniel Pugar, Dominik Brezetić, ]]></team_members_names><keywords_hr><![CDATA[Višerazinska analiza, samoobnavljajući materijali, mikromehanika, višeslojni kompoziti, napredne kompozitne konstrukcije]]></keywords_hr><keywords_en><![CDATA[Multiscale analysis, self-healing materials, micromechanics, layered composites, advanced composite structures]]></keywords_en><summary_hr><![CDATA[Predmet istraživanja je razvoj numeričke metodologije za modeliranje naprednih kompozitnih konstrukcija sa samoobnavljanjem mehaničkih svojstava. Istraživanje je usmjereno na nove vrste kompozitnih materijala s mogućnošću samoobnavljanja te će zbog toga razvoj numeričke metodologije biti usko povezan s eksperimentalnim istraživanjem. Princip samoobnavljanja temelji se na pristupu u kojemu je zacjeljivanje (obnavljanje) mehaničkih svojstava inicirano samom pojavom oštećenja u konstrukciji. Ovaj proces može biti unutarnji (autonoman) ili izazvan vanjskim utjecajem (grijanje, ultraljubičasto zračenje ili neka druga vanjska pobuda). Numerička metodologija za kompozitne materijale sa samoobnavljanjem svojstava će se temeljiti na višerazinskim metodama, budući da se načini popuštanja kompozitnih konstrukcija i događaju na različitim razinama. Višerazinski pristup će omogućiti daljnji razvoj konstitutivnih modela, kao i modela mehanike oštećenja i homogenizacije mehaničkih svojstava kompozitnog materijala. Metodologija će biti prilagođena primjeni na materijalnim sustavima samoobnavljanja s ciljem primjene na konstruktivnim elementima budućih konstrukcija.  Stoga se predloženo istraživanje temelji na naprednim analitičkim i polu-analitičkim mikromehaničkim modelima koji su atraktivna alternativa potpuno numeričkim modelima.Razvijena višerazinska metodologija će biti verificirana usporedbom s eksperimentalnim istraživanjem.  Biti će istražena mehanička svojstva i efikasnost zacjeljivanja vlaknima ojačane termoplastične matrice, sa prethodno dokazanim svojstvima samozacjeljivanja. Kompozit uključuje jednousmjerena ugljična vlakna u djelomično neutraliziranom poly(ethylene-co-methacrylic acid) ionomernom kopolimeru, Surlyn 8940 (DuPont). Širi cilj provođenja eksperimenata biti će istraživanje primjene razmatranih samoobnavljaućih materijalnih sustava u potencijalnoj budućoj primjeni u kompozitnim konstrukcijama. ]]></summary_hr><summary_en><![CDATA[The project deals with the development of a numerical methodology for modelling of advanced composite structures with self-healing capabilities. The research is aimed at a novel composite material with intrinsic self-healing capability. Therefore, the development of the numerical procedures will be supported by experimental analyses. Self-healing includes a new paradigm where the healing process is initiated by the damage itself within the mechanical component. The numerical methodology for self-healing composites will be based on multiscale concepts, since the failure modes of composite structures appear at different length scales. Application of the multiscale methodology will enable the further development of constitutive models, as well as damage models and material homogenisation of the composite material, to be applied in self-healing structures with the future final goal of application various structural elements. Therefore, an important aspect of the numerical model is computational efficiency at the micro-scale of the heterogeneous material which will allow structural scale application of the multiscale approach. Consequently, the proposed research is based on advanced analytical and semi-analytical micromechanical models which present an attractive alternative to purely numerical models. The developed multiscale methodology will be validated by comparison with experimental investigation. Mechanical properties and healing efficiency of a fibre reinforced thermoplastic resin with previously proved self-healing properties will be investigated. The composite incorporates uniaxially aligned carbon fibres in a partially neutralised poly(ethylene-co-methacrylic acid) ionomer copolymer, Surlyn 8940 (DuPont). A further objective of the experiments will be to investigate the applicability of the evaluated self-healing material system for a possible future application in composite structures.]]></summary_en></project><project>
<id>7768</id><title_hr><![CDATA[Nanofluidics and Ultrafiltration with Track-Etched Graphene-Polymer-Composite Membranes  (NU-TEGRAM)]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3498</user_id><user_firstLast_name>Marko Karlušić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-5631</code><acronim><![CDATA[]]></acronim><duration>01.10.2018 - 31.12.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>25293</team_members_id><team_members_names><![CDATA[ Doktorand: Damjan Iveković ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>7769</id><title_hr><![CDATA[Transformacija rada u posttranzicijskoj Hrvatskoj]]></title_hr><title_en><![CDATA[]]></title_en><user_id>12526</user_id><user_firstLast_name>Reana Senjković-Svrčić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-8599</code><acronim><![CDATA[TRANSWORK]]></acronim><duration>02.07.2018 - 03.07.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Etnologija i antropologija, </scie_field_hr><scie_field_en>Ethnology and anthropology, </scie_field_en><institution_hr><![CDATA[Institut za etnologiju i folkloristiku]]></institution_hr><institution_en><![CDATA[Institute of Ethnology and Folklore Research in Zagreb]]></institution_en><team_members_id>25145</team_members_id><team_members_names><![CDATA[ Doktorand: Romana Pozniak ]]></team_members_names><keywords_hr><![CDATA[transformacija, rad, posttanzicija, Hrvatska, etnografija rada]]></keywords_hr><keywords_en><![CDATA[transformation, work, post-transition, Croatia, ethnography of work]]></keywords_en><summary_hr><![CDATA[Na tragu kontinuiranog praćenja postsocijalističkih procesa predloženi projekt u hrvatsku etnologiju i kulturnu antropologiju uvodi subdisciplinu antropologije rada. Unutar interdisciplinarnog okvira oslonjenog na recentna postignuća europske antropologije, antropologije (post)socijalizma, antropologije rada, kritičkih studija rada, ekonomske antropologije itd., predložena konceptualna i neposredna etnografska istraživanja usredotočit će se na radnu svakodnevicu građana posttranzicijske Hrvatske. Istraživanja će pratiti dinamiku promjena i prilagodbi radne i životne ekonomije kroz efekte koji su u posttranzicijskoj Hrvatskoj dramatično promijenili iskustvo rada te će propitati nove kulturne imaginarije vezane uz ideju rada i projekciju budućnosti. Metodološki, projekt se temelji na empirijskim, etnografskim istraživanjima koja će se provesti na odabranim lokalitetima u Dalmaciji, Istri, Slavoniji, Baniji i u Zagrebu. Suradnici projekta TRANSWORK će, kvalitativnom metodom polustrukturiranih intervjua, razgovarati s informatorima o njihovim očekivanjima, ukoliko su zaposleni, o životu bez rada onih koji nisu zaposleni, o njihovom viđenju budućnosti, ali i o njihovim sjećanjima na rad i život kakav je nekad bio. Osim empirijskog dijela, projekt će se baviti i praćenjem koncepata i prakse rada u društvenopovijesnom kontinuitetu (od socijalističkog razdoblja do postsocijalističke periferije i krize neoliberalizma). Na osnovi arhivskih i teorijskih istraživanja, ali i izravnom metodom usmjerenih intervjua, ispitat će se koncepti, vrijednosti i praksa tradicionalnih modela rada koji sežu u socijalističko nasljeđe radničkog etosa te tranzicije industrijskog u aktualni, uslužni sektor djelatnosti.]]></summary_hr><summary_en><![CDATA[As part of the continual following of post-socialist processes the proposed project introduces to Croatian ethnology and cultural anthropology a sub-discipline of anthropology of work. Within the interdisciplinary framework based on the recent accomplishments of European anthropology, the anthropology of (post)socialism, anthropology of work, critical studies of work, economic anthropology etc., the proposed conceptual and ethnographic research will focus on the working everyday life of the citizens of post-transitional Croatia.The research will follow the dynamics of adjustment of the work and life economy in post-transitional Croatia through the effects that have dramatically changed the experience of work. It will examine new cultural imageries connected with the idea of work and projections for the future. The project will be based on empirical, ethnographic research method. Semi-structured interviews will be conducted at the selected locations in Dalmatia, Istria, Slavonia, Banija and in the town of Zagreb. The TRANSWORK team members will be interested in informants&#39; expectations, if they are employed, in their everyday life without work if they are unemployed, in their seeing of the future, but also in their memories of the life as it once was.In addition to the empirical part, project will be monitoring the concepts and work practices in social and historical continuity (spanning from the socialist period to the post-socialist periphery and the crisis of neo-liberalism). This includes archival and theoretical research, focused interviews of work models which derive from the socialist heritage of workers’ ethos, as well as professional and identity transitions into the industrial and service sector activities.]]></summary_en></project><project>
<id>7773</id><title_hr><![CDATA[Regulacija prostitucije u Hrvatskoj]]></title_hr><title_en><![CDATA[Regulation of Prostitution in Croatia]]></title_en><user_id>12713</user_id><user_firstLast_name>Ivana Radačić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-3878</code><acronim><![CDATA[ProReg]]></acronim><duration>02.05.2019 - 01.05.2023</duration><status>Završio</status><financ_value>61.177,64 eur</financ_value><scie_area_hr>Interdisciplinarno područje znanosti</scie_area_hr><scie_area_en>Interdisciplinary scientific area</scie_area_en><scie_field_hr>Rodni studiji, </scie_field_hr><scie_field_en>Gender Studies, </scie_field_en><institution_hr><![CDATA[Institut društvenih znanosti Ivo Pilar]]></institution_hr><institution_en><![CDATA[Institute of Social Sciences Ivo Pilar in Zagreb]]></institution_en><team_members_id>24073, 18985, 13332, 13435, 24090, 24123, 25936, 5678, </team_members_id><team_members_names><![CDATA[Mirjana Adamović, Rašeljka Krnić, Tihana Štojs Brajković, Josip  Šipić, Nikola Baketa, Stephanie Stelko, Marija Antić, Antonija Petričušić, ]]></team_members_names><keywords_hr><![CDATA[prostitucija, regulacija, politike, stavovi, iskustva]]></keywords_hr><keywords_en><![CDATA[prostitucija, regulacija, politike, stavovi, iskustva]]></keywords_en><summary_hr><![CDATA[Prostitucija je kompleksan društveni fenomen oko kojeg postoje brojne kontroverze, pa i po pitanju najprikladnijih javnih politika i pravnih rješenja. Hrvatska je jedna od rijetkih europskih zemalja u kojoj je „odavanje prostituciji“ kažnjivo, a tema u znanosti zanemarena. Nedavno završeno prvo interdisciplinarno kvalitativno istraživanje prostitucije u Hrvatskoj pokazalo da je pravni okvir jedna od ključnih odrednica iskustava osoba koje se bave prostitucijom (Radačić i Pajnik, 2017). Ovaj, teorijski i metodološki ambiciozniji projekt, nastavlja se na navedeno istraživanje, usredotočujući se na regulaciju prostitucije u Hrvatskoj i njezinih učinaka na osobe koje se bave prostitucijom. Projekt je interdisciplinaran i uključuje polja prava, sociologije i politologije. U teorijskom smislu nastavlja se na feminističku i ljudskopravnu literaturu koja propituje regulatorne modele koje počivaju na dominantnom dihotomnom shvaćanju prostitucije kao rada ili nasilja (Scoular, 2015.; Munro i Della Giusta, 2016.; Marshall, 2016; Larson i Hernandez Truyol, 2006). Ciljevi projekta su opisati razvoj politika prostitucije u Hrvatskoj, analizirati postojeće zakone i sudsku praksu te propitati usklađenost hrvatskog modela sa standardima zaštite ljudskih prava, istražiti stavove stručnjaka o prostituciji i zakonskim rješenjima te iskustva osoba koje se bave prostitucijom, predložiti smjernice za izradu javnih politika, proširiti znanstvene spoznaje o prostituciji i povećati istraživačke kapacitete tima. Osim analize zakona, sudskih postupaka te dokumenata javnih politika, projekt predviđa i kvalitativno istraživanje s osobama koje se bave prostitucijom te predstavnicima relevantnih ministarstava, udruga i nezavisnih institucija za zaštitu ljudskih prava, kao i stručnjacima pravosudnog i policijskog sustava. Projekt donosi nove interdisciplinarne spoznaje o slabo istraženom fenomenu, koje su primjenjive u izradi i implementaciji javnih politika.]]></summary_hr><summary_en><![CDATA[Prostitution is a complex social phenomenon, which entails many controversies related to the best public policy and legislative solutions. Croatia is one of the very few European countries in which involvement in prostitution is criminalised, while the topic is neglected in scientific production. The recent first empirical interdisciplinary study on prostitution has shown how prostitution laws have a significant impact on experiences of persons involved in prostitution (Radačić and Pajnik, 2017). This, theoretically and methodologically more ambitious project is a continuation of the previous research, focused on regulation of prostitution in Croatia. It is an interdisciplinary project that gathers researchers from legal studies, sociology and political science. At the theoretical level, it builds on feminist and human rights literature on prostitution that challenges regulatory models rooted in the dominant dichotomous understanding of prostitution as work or violence (Scoular, 2015; Munro and Della Giusta, 2016; Marshall, 2016; Larson and Hernandez Truyol, 2006). The project aims to describe the development of prostitution policies in the European context, analyse the existing legislation and case-law and assess its compatibility with human rights standards, investigate experts’ attitudes on prostitution and legal solutions, examine sex workers’ experiences, propose policy design guidelines, broaden knowledge on prostitution and expand research capacities of the project team. Besides analysing laws, judicial practice and policy documents, it also includes qualitative research sex workers and two categories of experts – the representatives of relevant ministries, NGOs and human rights institutions and judicial and police officials. The project brings new interdisciplinary perspectives on this marginalised topic, which are applicable in design and implementation of public policies.  ]]></summary_en></project><project>
<id>7774</id><title_hr><![CDATA[Karakterizacija hrskavice acetabuluma i femura u odraslih bolesnika s razvojnim poremećajem kuka]]></title_hr><title_en><![CDATA[Acetabular and femoral cartilage characterization in adult patients with developmental dysplasia of the hip ]]></title_en><user_id>7499</user_id><user_firstLast_name>Domagoj  Delimar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-3688</code><acronim><![CDATA[HIPoCART]]></acronim><duration>01.12.2018 - 30.11.2022</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Clinical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>7637, 4726, 24258, 28649, 28720, 28727, </team_members_id><team_members_names><![CDATA[Ivan Bohaček, Ivan Dobrić, Tomislav Smoljanović, Tea Duvančić, Mihovil Plečko, Andreja Vukasović Barišić, ]]></team_members_names><keywords_hr><![CDATA[Hrskavica, Razvojni poremećaj kuka, Multimodalna karakterizacija, Histologija, Ortopedija]]></keywords_hr><keywords_en><![CDATA[Cartilage, Developmental dysplasia of the hip, Multimodal characterisation, Histology, Orthopaedics]]></keywords_en><summary_hr><![CDATA[Razvojni poremećaj kuka u odrasloj dobi (RPKOD) predstavlja jedan od najčešćih uzroka sekundarne koksartroze. Ovim projektom razjasniti će se po prvi put histološka građa hrskavice glave femura i acetabuluma koja u visokim stupnjevima RPKOD (Crowe 3. i 4. stupanj) nije u kontaktu s kontralateralnim zglobnim tijelom. Nepostojanje međusobnog kontakta zglobnih tijela tijekom razvoja čini prirodni eksperiment koji je prisutan u bolesnika s visokim stupnjem RPKOD, budući da se hijalina hrskavica kod tih bolesnika razvija bez prisutnosti mehaničkog opterećenja. Karakterizacijom građe hrskavice potvrditi će se i/ili redefinirati i modificirati općeprihvaćena paradigma koja podrazumijeva nužno postojanje mehaničke sile kao neophodnog preduvjeta za uredan razvoj hijaline hrskavice zgloba kuka. Uzorci tkiva hrskavice te subhondralne kosti acetabuluma, neoacetabuluma i femura će se prikupiti tijekom ugradnje totalne endoproteze (TEP) kuka u bolesnika s razvijenom sekundarnom koksartrozom zbog RPKOD (Crowe 3 i 4). Dobiveni rezultati usporediti će se s rezultatima analize uzoraka hrskavice bolesnika s primarnom koksartrozom, te bolesnika s očuvanom hrskavicom koji podliježu operativnom zahvatu ugradnje TEP kuka zbog prijeloma u području kuka (kontrolne skupine). Provesti će se snimanje strukture uzoraka hrskavice i subhondralne kosti magnetskom rezonancom uređajem od 7T te mikro-kompjuteriziranom tomografijom. Potom će se provesti karakterizacija mikroskopske građe hrskavice primjenom niza različitih histoloških obilježavanja (klasična i specifična histološka bojenja, imunohistokemijska obilježavanja pojedinih podvrsta kolagena i sl.), uz adekvatnu analizu slika. Rezultati istraživanja uvelike će pridonijeti općem razumijevanju razvoja hijaline hrskavice i subhondralne kosti, a posebice utjecaja mehaničkog stimulusa u istome. Očekuje se značajan utjecaj dobivenih rezultata na područje regenerativne medicine kao i translacija dobivenih rezultata na kliničku praksu.]]></summary_hr><summary_en><![CDATA[Developmental dysplasia of the hip (DDH) is one of the most common causes of secondary hip osteoarthritis in adult population. In higher grades of DDH in adult age (Crowe grade 3 or 4), in more than 75% of the cartilage surface there is no contact between acetabulum and femur. In this project, cartilage and subchondral bone structure on both articular surfaces will be characterized for the first time, using different approaches. Lack of contact between these cartilage surfaces represents a natural experiment, since the development of such cartilage does not include mechanical load. Characterization of the articular cartilage structure will either confirm or redefine and modify the currently accepted paradigm that mechanical load is crucial for normal development of joint cartilage. Tissue samples of acetabulum, neoacetabulum and femoral head, including cartilage and underlying subchondral bone will be harvested during total hip arthroplasty (THA) in patients with secondary hip osteoarthritis caused by DDH (Crowe 3 or 4). Results will be compared to the results of samples harvested in patients suffering from primary hip osteoarthritis, or patients with femoral neck fracture that require THA, but have healthy cartilage (control group). Samples will be scanned using 7T micro-magnetic resonance imaging as well as micro computed tomography. Afterwards, samples will be microscopically analysed using specific histological staining protocols and immunohistochemical labelling of e.g. various collagen subtypes etc. Results of this project will merely influence general understanding of cartilage and subchondral bone development. These results will determine whether mechanical load plays crucial role for proper cartilage formation. Results of this project will definitely have impact on the field of regenerative medicine, and translation of these results to clinical practice is expected as well.]]></summary_en></project><project>
<id>7775</id><title_hr><![CDATA[Napredne metode i tehnologije u znanosti o podatcima i kooperativnim sustavima (DATACROSS)]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1480</user_id><user_firstLast_name>Mile Šikić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-3373</code><acronim><![CDATA[]]></acronim><duration>22.10.2018 - 20.10.2021</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>25374</team_members_id><team_members_names><![CDATA[ Doktorand: Lovro Vrček ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>7777</id><title_hr><![CDATA[Epigenetički biomarkeri raka prostate]]></title_hr><title_en><![CDATA[]]></title_en><user_id>19967</user_id><user_firstLast_name>Monika Ulamec</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-1477</code><acronim><![CDATA[]]></acronim><duration>29.10.2018 - 28.10.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Clinical sciences, </scie_field_en><institution_hr><![CDATA[Klinički bolnički centar "Sestre Milosrdnice", Zagreb]]></institution_hr><institution_en><![CDATA[Clinical Hospital Center "Sestre Milosrdnice", Zagreb]]></institution_en><team_members_id>25378</team_members_id><team_members_names><![CDATA[ Doktorand: Lucija Škara ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>7778</id><title_hr><![CDATA[Utjecaj različitih vinifikacijskih tehnologija na kvalitativna svojstva vina od autohtonih hrvatskih sorti: uloga vina u ljudskoj prehrani]]></title_hr><title_en><![CDATA[Influence of different vinification technologies on the qualitative characteristics of wines from Croatian autochthonous varieties: the role of wine in human diet]]></title_en><user_id>6511</user_id><user_firstLast_name>Sanja Radeka</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-5049</code><acronim><![CDATA[VINUM SANUM]]></acronim><duration>27.12.2018 - 26.12.2022</duration><status>Završio</status><financ_value>174.945,74 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, Prehrambena tehnologija, </scie_field_hr><scie_field_en>Agriculture, Food technology, </scie_field_en><institution_hr><![CDATA[Institut za poljoprivredu i turizam]]></institution_hr><institution_en><![CDATA[Institute of Agriculture and Tourism in Poreč]]></institution_en><team_members_id>7005, 23748, 23506, 5208, 13383, 6224, 13660, 23781, 23521, 1182, 222, 25498, 855671, 865018, </team_members_id><team_members_names><![CDATA[Marijan Bubola, Andreja Vanzo, Teodora Zaninović Jurjević, Štefica Dvornik, Anita Silvana Ilak Peršurić, Karin Kovačević Ganić, Tomislav Plavša, Klemen Lisjak, Dejan Bavčar, Irena Budić-Leto, Marina Tomašević, Sara Rossi , Ena Bestulić, Fumica Orbanić, ]]></team_members_names><keywords_hr><![CDATA[vino, vinifikacijske tehnologije, polifenoli, antioksidanti, ljudsko zdravlje]]></keywords_hr><keywords_en><![CDATA[wine, vinification technology, polyphenols, antioxidants, human health]]></keywords_en><summary_hr><![CDATA[Postoji veliki nedostatak objektivnih spoznaja o utjecaju primjene različitih vinifikacijskih tehnologija na kvalitativna svojstva vina od hrvatskih autohtonih bijelih  crnih sorti vinove loze, te njihove uloge u ljudskoj prehrani. Cilj ovog projekta je utvrditi razlike između kvalitativnih svojstava mladih (svježih) i zrelih (odležalih) vina gospodarski najvažnijih hrvatskih autohtonih bijelih i crnih sorti vinove loze (Malvazija istarska, Teran, Pošip i Plavac mali), proizvedenih različitim tehnologijama vinifikacije (kao što su standardna „brza prerada“ bez maceracije masulja, sa dodatkom i bez dodatka enoloških tanina, kratkotrajna, predfermentativna (crio) maceracija, dugotrajna, postfermentativna maceracija masulja i odležavanje vina u drvenim bačvama), te utjecaj njihove umjerene, kontrolirane konzumacije na psiho-fizičko zdravlje skupina ispitanika uključenih u istraživanje. Proizvedena vina biti će podvrgnuta detaljnoj analizi osnovnog fizikalno-kemijskog sastava, sastava hlapljivih armatskih spojeva, fenolnih spojeva, antioksidacijskog potencijala i nutritivnih svojstva, te će vina biti i senzorno ocjenjena. Posebna pozornost posvetit će se istraživanju spojeva zaslužnih za biološku aktivnost vina i njegovu pozitivnu ulogu u ljudskoj prehrani. Skupine ispitanika uklučene u istraživanje biti će podvrgnute kontroliranoj umjerenoj konzumaciji bijelih i crnih vina, proizvedenih specifičnim tehnologijama, u trajanju od 1-3 mjeseca, te će im se redovito kontrolirati zdravstveni parametri (tlak, šećer, kolesterol LDL, HDL, hormoni „sreće“ itd.). Također ispitanici će biti anketirani, prema unaprijed razrađenim anketnim upitnicima, o razini raspoloženja prije i nakon umjerene konzumacije vina. ]]></summary_hr><summary_en><![CDATA[There is a great lack of objective knowledge of the influence of the use of different vinification technologies on the qualitative properties of wines produced from Croatian autochthonous white grape varieties of vines and their role in human nutrition. The aim of this project is to determine the differences between the qualitative characteristics of young (fresh) and mature (aged) wines of the most important Croatian autochthonous white and black grape varieties (Malvazija istarska, Teran, Pošip and Plavac mali) produced by various vinification technologies (such as standard &#39;&#39;rapid processing&#39;&#39; without maceration of the grape mash, with addition and without the addition of oenological tannins, short-term pre-fermentation (cryo) maceration, long-lasting, post fermentative maceration and maturation of wine in wooden barrels), and the influence of moderate, controlled consumption of wine on the psychophysical health of surveyed groups. Produced wines will be subjected to a detailed analysis of the basic physical-chemical composition, volatile compounds, phenolic compounds, antioxidant potential and nutritional properties, and the wines will be sensoricaly evaluated. Particular attention will be paid to the research of compounds responsible for the bioactivity of wine and its positive role in human diet. The groups of participants surveyed will be subjected to controlled moderate consumption of white and black wines produced by specific technologies for 1-3 months and human health parameters will be regularly monitored (blood pressure, sugar, LDL cholesterol, HDL, &#39;&#39;happiness hormones&#39;&#39;, etc.). Also, participants will be interviewed, according to pre-elaborated questionnaires, about the psychological state before and after moderate consumption of wine.]]></summary_en></project><project>
<id>7781</id><title_hr><![CDATA[Proučavanje reperfuzijske ozljede u ljudskom srcu; sprječavanje negativnih aspekata vitalnog terapeutskog postupka]]></title_hr><title_en><![CDATA[]]></title_en><user_id>168</user_id><user_firstLast_name>Marko Ljubković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-4748</code><acronim><![CDATA[REFINE]]></acronim><duration>01.09.2018 - 01.09.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Split School of Medicine]]></institution_en><team_members_id>25252</team_members_id><team_members_names><![CDATA[ Doktorand: Ivan Mihanović ]]></team_members_names><keywords_hr><![CDATA[srčana, ljudska, ishemija, reperfuzija, terapija]]></keywords_hr><keywords_en><![CDATA[cardiac, human, ischemia, reperfusion, therapy]]></keywords_en><summary_hr><![CDATA[Smrtnost od kardiovaskularnih bolesti, unatoč unaprijeđenim preventivnim i terapijskim mjerama koje su rezultirale poboljšanim trendovima preživljenja zadnjih godina, još uvijek predstavlja glavni uzrok smrti u svijetu. Ponovna uspostava protoka krvi kroz prethodno začepljene ogranke koronarne arterije je glavni cilj terapeutskog postupka neophodnog u svrhu smanjenja odumiranja srčanog mišićnog tkiva. Međutim, postoji niz dokaza da i sama reperfuzija dijelom dovodi do oštećenja tkiva te da doprinosi sa čak 50% u konačnoj veličini infarkta miokarda. Stoga je veliki broj istraživanja usmjeren pronalaženju postupaka kojima bi se smanjila srčana reperfuzijska ozljeda, od kojih su neki dosegnuli i razinu kliničkih istraživanja. Međutim, rezultati provedenih kliničkih studija su bili mahom negativni, pa je translacija eksperimentalnih podataka, koji su na staničnim i životinjskim modelima bili obećavajući, dosad bila neuspješna. U predloženom projektu planiramo istražiti glavne patološke elemente reperfuzijske ozljede u srčanom tkivu bolesnika s koronarnom bolešću koji će biti podvrgnuti operaciji postavljanja srčane premosnice. Pritom ćemo koristiti suvremene eksperimentalne metode procjene razine slobodnih kisikovih radikala, parametara oštećenja mitohondrija i analize metabolita tijekom ishemije i rane faze reperfuzije, kada je poznato da se većina tkivne ozljede događa. Također planiramo razvoj eksperimentalne platforme koja će omogućiti istraživanje raznih protektivnih postupaka u ljudskom srčanom tkivu, stanicama i mitohondrijima. Svrha predloženog pristupa je omogućiti ispitivanje i translaciju eksperimentalnih rezultata dobivenih temeljnim istraživanjima u kliničku uporabu te u konačnici dati doprinos razvoju terapije reperfuzijske ozljede.]]></summary_hr><summary_en><![CDATA[Mortality due to cardiovascular diseases, despite improved preventive and therapeutic measures that resulted in beneficial trends in the last decades, still remains the main global cause of death. Re-establishment of coronary blood flow following an ischemic period is the main goal of coronary recanalization therapies and is essential for reducing myocardial ischemic damage. However, there is ample evidence that reperfusion itself, besides bringing nutrients and oxygen back to the energy-deprived myocardium, can actually further induce cardiomyocyte death. This reperfusion injury is considered to account up to 50% of the final myocardial damage. Therefore, a great number of research studies focused their efforts on finding various modes of attenuation of the reperfusion injury, with many of them reaching even clinical setting. However, due to negative results of clinical studies, translation of experimental data that showed efficient cardiac protection in cellular and animal models of ischemia-reperfusion has been largely unsuccessful. In the proposed project, we aim to investigate the main culprits of reperfusion injury in myocardial tissue obtained from patients suffering from coronary heart disease and undergoing coronary artery bypass graft (CABG) surgery. We will use state-of-the-art experimental approaches for assessment of free oxygen radicals, mitochondrial damage and metabolomic analysis during ischemia and at the early onset of reperfusion, the time-point which was shown to be responsible for the most of reperfusion injury. Moreover, we propose to develop an experimental platform for investigation of various (potentially) cardioprotective strategies in human cardiac tissue, cells and mitochondria. The purpose of such approach is to bring closer to clinics some of the experimental findings obtained in animal models of the disease and ultimately come closer to reducing the reperfusion injury.]]></summary_en></project><project>
<id>7782</id><title_hr><![CDATA[Utjecaj vrlo brzih prijelaznih pojava na kapacitivno gradiranu uljno-papirnu izolaciju]]></title_hr><title_en><![CDATA[Capacitively graded oil-paper insulation behavior under very fast transients]]></title_en><user_id>324</user_id><user_firstLast_name>Tomislav Župan</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-3670</code><acronim><![CDATA[CROPIBUFT]]></acronim><duration>01.11.2018 - 15.03.2023</duration><status>Završio</status><financ_value>118.973,30 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, Kemijsko inženjerstvo, </scie_field_hr><scie_field_en>Electrical engineering, Chemical engineering, </scie_field_en><institution_hr><![CDATA[KONČAR - Institut za elektrotehniku d.d., Zagreb]]></institution_hr><institution_en><![CDATA[KONčAR - Institute for Electrical Engineering, Zagreb]]></institution_en><team_members_id>1373, 2792, 23680, 24242, 6797, </team_members_id><team_members_names><![CDATA[Dalibor Filipović-Grčić, Igor Žiger, Ivan Novko, Petar Gabrić, Bruno Jurišić, ]]></team_members_names><keywords_hr><![CDATA[uljno-papirna izolacija, kapacitivno gradirana izolacija, prijelazne pojave, vrlo brzi prenaponi, udarni generator, parcijalna izbijanja]]></keywords_hr><keywords_en><![CDATA[oil-paper insulation, capacitively graded insulation, transient overvoltages, very fast overvoltage transients, impulse generator, partial discharges]]></keywords_en><summary_hr><![CDATA[Kapacitivno gradirana uljno-papirna izolacija je osnovna vrsta električke izolacije mnogih električnih uređaja, poput provodnika i mjernih transformatora. Unatoč tome što je cjenovni udio tih uređaja u sustavu opskrbe električnom energijom minimalan, njihovi kvarovi uzrokuju prekide u opskrbi te time i veliku ekonomsku štetu. Zbog toga oni predstavljaju sigurnosni i ekonomski rizik koji se danas umanjuje kvalitetnim dizajnom, sustavom monitoringa te preventivnom zamjenom.U današnje je vrijeme elektroenergetski sustav izraženije izložen prijelaznim stanjima zbog sve većeg broja obnovljivih izvora električne energije u sustavu. Oni zbog svoje dislociranosti i nestalnosti rada uzrokuju povećan broj sklopnih operacija u sustavu. Također, zbog porasta udjela plinom oklopljenih rasklopnih postrojenja, raste i broj vrlo brzih prijelaznih pojava. U novije vrijeme, uobičajena se mineralna ulja zbog sigurnosnih i ekoloških razloga nastoje zamijeniti prirodnim ili sintetskim esterima, čiji je utjecaj električki gledano još nedovoljno poznat. Zbog svega navedenog, električki se uređaji u prijenosnom sustavu izlažu većim dugoročnim naprezanjima te je potrebno istražiti utjecaj tih pojava na njihovu izolaciju.U navedenom projektu će se konstruirati kućište modela prikladno za ispitivanje vrlo brzih prijelaznih pojava te osigurati eksperimentalni postav za kvalitetno mjerenje svih tipova naponskih prijelaznih pojava. Istraživanjem utjecajnih i kontrolnih parametara, napravit će se ispitni plan kojim će se kvalitetno istražiti utjecaj navedenih pojava na kapacitivno gradiranu uljno-papirnu izolaciju. Različiti materijali kapacitivnih obloga i vrsta ulja bit će uzeti u obzir.Očekivani doprinos projekta je proširenje znanja o ponašanju kapacitivno gradirane uljno-papirne izolacije prilikom prijelaznih pojava čime se može doprinijeti optimizaciji dizajna električkih uređaja i njihovog monitoringa te time povećati njihovu sigurnost i smanjiti utjecaj na okoliš.]]></summary_hr><summary_en><![CDATA[Capacitively graded oil-paper insulation is the basis of electrical insulation for many electrical devices, such as bushings and instrument transformers. Despite their relative low cost in overall electrical energy distribution system, failures of such devices lead to distribution interruptions and can cause great economic losses. As such, they represent safety and economic risks that are today being alleviated by proper design, monitoring systems and preventive replacement.Power utility system is nowadays more frequently exposed to overvoltage transients due to the increase in renewable sources. Since they are dislocated and naturally inconsistent in operation, they attribute to the increase of switching operations. Moreover, since the gas insulated switchyards are becoming more widely used, the number of very fast transients is also on the rise. Because of better safety and ecological aspects, accustomed mineral oil is lately being replaced with natural or synthetic esters, whose electrical effects are still not adequately known. All things considered, electrical devices throughout the system are being more frequently and severely stressed. The influence of the mentioned effects on their insulation properties should be investigated thoroughly.In this project, the model housing for very fast overvoltage transient testing will be developed together with the experimental setup capable of producing and measuring all overvoltage transient signals. Investigating the influential and control parameters, the test plan for the measurement procedure will be given. Different materials for the capacitive sheets and oil types will be taken into account.Expected contribution of the project is the increase of knowledge of the capacitively graded oil-paper insulation behavior under overvoltage transients. This can lead to better device optimization and monitoring techniques which will enhance the safety of electrical devices and reduce their environmental footprint.]]></summary_en></project><project>
<id>7784</id><title_hr><![CDATA[UIP-05-2017 Metode za interpretaciju medicinskih snimki za detaljnu analizu zdravlja srca (IMAGINE HEART)]]></title_hr><title_en><![CDATA[]]></title_en><user_id>21436</user_id><user_firstLast_name>Irena Galić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-6211</code><acronim><![CDATA[]]></acronim><duration>03.09.2018 - 31.01.2021</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera Osijek, Fakultet elektrotehnike, računarstva i informacijskih tehnologija Osijek]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Electrical Engineering, Computer Science and Information Technology Osijek]]></institution_en><team_members_id>25211</team_members_id><team_members_names><![CDATA[ Doktorand: Filip Novoselnik ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>7785</id><title_hr><![CDATA[Istraživanje recentnih regionalnih i lokalnih geodinamičkih procesa na području Republike Hrvatske primjenom suvremenih satelitskih geodetskih metoda]]></title_hr><title_en><![CDATA[Research of recent regional and local geodynamic processes in the Republic of Croatia using modern satellite geodetic methods]]></title_en><user_id>7681</user_id><user_firstLast_name>Boško Pribičević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-8944</code><acronim><![CDATA[GEOMSAT]]></acronim><duration>05.10.2018 - 04.10.2022</duration><status>Završio</status><financ_value>132.822,35 eur</financ_value><scie_area_hr>Tehničke znanosti, Prirodne znanosti, </scie_area_hr><scie_area_en>Technological sciences, Natural sciences, </scie_area_en><scie_field_hr>Geodezija, Geologija, Geofizika, </scie_field_hr><scie_field_en>Geodesy, Geology, Geophysics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Geodetski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Geodesy]]></institution_en><team_members_id>21337, 21358, 21348, 3304, 21333, 21347, 21383, 20328, 12913, 22798, 26457, 26426, 12406, </team_members_id><team_members_names><![CDATA[Almin Đapo, Boštjan Kovačič, Rok Kamnik, Ante Marendić, Luka Babić, Marin Govorčin, Eduard Prelogović, Vanja Miljković, Snježan Prevolnik, Ivica Pavičić Pavičić, Marijan Marjanović, Marko Pavasović, Bojan  Matoš, ]]></team_members_names><keywords_hr><![CDATA[geodinamika, Jadranska mikroploča, potresi, satelitske geodetske metode, GNSS, MT-InSAR, prostorne baze podataka]]></keywords_hr><keywords_en><![CDATA[geodynamics, Adriatic microplate, earthquakes, satellite geodetic methods, GNSS, MT-InSAR, spatial databases]]></keywords_en><summary_hr><![CDATA[Istraživanje geodinamičkih procesa od izuzetne je važnosti za razumijevanje mehanizama koji dovode do potresa. Razvojem suvremenih geodetskih satelitskih metoda prikupljanja prostornih podataka, uloga geodezije u predmetnim interdisciplinarnim istraživanjima značajno je povećana. Glavni ciljevi projektnog prijedloga su prikupljanje novih i poboljšanje postojećih znanja o recentnim geodinamičkim procesima na području Republike Hrvatske. To se planira postići primjenom suvremenih geodetskih satelitskih metoda: Globalni Navigacijski Satelitski Sustav (GNSS) i Multi-temporalna Satelitska Radarska Interferometrija (MT-InSAR) te interdisciplinarnom analizom dobivenih geodetskih podataka s geološkim i seizmološkim podacima. Poboljšanje postojećih znanja o recentnim geodinamičkim procesima na području Republike Hrvatske ostvariti će se istraživanjem navedenih procesa koji se odvijaju na širem (regionalnom) području, dobivanjem kinematičkog modela Jadranske mikroploče, na temelju izjednačenja regionalne GNSS mreže koja uključuje GNSS stanice nacionalnih mreža u regiji (Hrvatske, Italije, Slovenije, Mađarske, BiH i Crne Gore). Nadalje, poboljšanje navedenih znanja ostvariti će se i na lokalnoj razini karakterizacijom i kvantifikacijom recentne tektonske aktivnosti na glavnim rasjednim zonama na širim područjima gradova Rijeke i Dubrovnika, primjenom MT-InSAR metoda. Rezultati dobiveni geodetskim, geološkim i seizmološkim metodama integrirati će se u zajedničku bazu podataka i WebGIS aplikaciju, na temelju kojih će se uspostaviti visoko kvalitetna geodetsko-geodinamička osnova za daljnja istraživanja geodinamičkih procesa u RH i široj regiji. Uspostava navedene osnove od izuzetnog je značaja i za dobivanje pouzdanih procjena seizmičkog hazarda, te indirektno i za proces prostornog planiranja i gradnje prema europskoj normi EUROKOD8. Na taj način projektni prijedlog direktno i indirektno doprinosi očuvanju života i imovine stanovništva u Republici Hrvatskoj i široj regiji.]]></summary_hr><summary_en><![CDATA[Research of geodynamic processes are of utmost importance for understanding the mechanisms that lead to earthquakes. With the development of modern geodetic satellite methods, the role of geodesy has been significantly increased in geodynamic research. The main objectives of the project proposal are to collect new data and improve the existing knowledge on recent geodynamic processes in the Croatia by applying modern geodetic satellite methods, the GNSS and Multi-Temporal Satellite Radar Interferometry (MT-InSAR) and through interdisciplinary analysis of obtained data with geological and seismological data. Improvement of existing knowledge on recent geodynamic processes in the territory of the Republic of Croatia will be realized by researching these processes on the wider area (regional) by creating the kinematic model of the Adriatic microplate, based on the adjustment of the regional GNSS network that includes the GNSS stations of the national networks in the region (Croatia, Italy, Slovenia, Hungary, BiH and Montenegro). Furthermore, the improvement of the knowledge will be realized at the local level by characterizing and quantifying recent tectonic activity on the major fault zones in the wider areas of the cities of Rijeka and Dubrovnik, using MT-InSAR method. The results, obtained by geodetic, geological and seismological methods, will be integrated into the database and corresponding WebGIS application, based on which will be established high quality geodetic and geodynamic basis for further research of the geodynamic processes in the Croatia and the wider region. The establishment of this basis is of utmost importance for obtaining reliable estimates of seismic hazards, as well as indirectly for the process of spatial planning and construction according to EUROCODE8. In this way, the project proposal, directly and indirectly, contributes to the preservation of life and property in the Republic of Croatia and the wider region.]]></summary_en></project><project>
<id>7788</id><title_hr><![CDATA[Milimetarska i submilimetarska opažanja Sunčeve kromosfere pomoću ALMA-e]]></title_hr><title_en><![CDATA[Millimeter and submillimeter observations of the solar chromosphere with ALMA]]></title_en><user_id>6078</user_id><user_firstLast_name>Roman Brajša</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-7549</code><acronim><![CDATA[MSOC]]></acronim><duration>01.10.2018 - 30.09.2022</duration><status>Završio</status><financ_value>119.845,50 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Geodetski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Geodesy]]></institution_en><team_members_id>4850, 6028, 4326, 5899, 19711, 865039, </team_members_id><team_members_names><![CDATA[Bojan Vršnak, Davor Sudar, Domagoj Ruždjak, Jaša Čalogović, Ivica Skokić, Filip Matković, ]]></team_members_names><keywords_hr><![CDATA[kromosfera, radioastronomija, rotacija Sunca, prominencije, eruptivni procesi]]></keywords_hr><keywords_en><![CDATA[chromosphere, radio astronomy, solar rotation, prominences, eruptive processes]]></keywords_en><summary_hr><![CDATA[	Sunčeva kromosfera je dinamički sloj atmosfere Sunca smješten između fotosfere i korone koji igra važnu ulogu u prijenosu materije i energije u vanjske slojeve te je presudan za razumijevanje zagrijavanja korone. Potpuno razumijevanje ovog sloja još uvijek je nedostižno, uglavnom zbog nedostatka prikladnih opažačkih instrumenata i mjerenja. Cilj ovog projekta je analiza podataka iz solarnih opažanja s teleskopa Atacama Large Millimeter/submillimeter Array (ALMA), naprednog i trenutno najvećeg astronomskog instrumenta na Zemlji, kojim se mogu istraživati gotovo svi tipovi nebeskih objekata, uključujući Sunce. Glavna prednost solarnih opažanja s ALMA-om je mapiranje Sunčeve kromosfere s dosad nedostignutom prostornom, vremenskom i spektralnom razlučivosti u rasponu valnih duljina između 0,3 mm i 8,6 mm. ALMA se također može koristiti kao približno linearni termometar - izmjerena temperatura sjaja izravno je proporcionalna temperaturi plina opažane strukture ili sloja koji je izvor detektiranog kontinuiranog zračenja u Sunčevoj atmosferi. Visina stvaranja kontinuiranog zračenja povećava se s povećanjem valne duljine promatranja koja, zajedno s visokom spektralnom razlučivosti ALMA-e, omogućuje vrlo precizno mjerenje temperature kromosfere kao funkcije visine. Sve navedene prednosti ALMA-e omogućuju istraživanje trodimenzionalne strukture kromosfere i njenih mnogobrojnih zanimljivih dinamičkih pojava. Glavni cilj predloženog istraživanja je poboljšati razumijevanje kromosfere Sunca pomoću novog naprednog instrumenta ALMA-e. Da bismo ostvarili taj cilj, namjeravamo se usredotočiti na četiri glavne teme: analizu struktura velikih razmjera opažanih ALMA-om, analizu struktura malih razmjera opažanih ALMA-om, modeliranje i tumačenje ALMA promatranja te njihov utjecaj na druga područja fizike Sunca.]]></summary_hr><summary_en><![CDATA[Solar chromosphere is a dynamic interface layer of the Sun&#39;s atmosphere located between the photosphere and corona which plays an important role in transporting energy and matter into the outer layers and is crucial for understanding of coronal heating. Full understanding of this layer is still elusive mostly due to the lack of suitable measurements and instruments. The aim of this project is to utilize solar observations with the Atacama Large Millimeter/submillimeter Array (ALMA), a new state-of-the-art and currently the world largest ground-based astronomical facility, capable of observing almost all types of celestial objects including the Sun. The main advantage of ALMA solar observations is mapping of the solar chromosphere with an unprecedented spatial, temporal, and spectral resolution in the wavelength range between 0.3 mm and 8.6 mm. It can also be used as an approximately linear thermometer - the measured brightness temperature is directly proportional to the gas temperature of the observed structure or the continuum-forming layer in the solar atmosphere. Formation height of the continuum radiation increases with increasing wavelength of the observation which, coupled with ALMA&#39;s high spectral resolution, enables very accurate measurements of chromosphere&#39;s temperature as a function of height. All of these capabilities of ALMA will provide the possibility to investigate full 3D structure of the chromosphere and many interesting dynamic phenomena therein.  The main goal of the proposed research is to improve understanding of the solar chromosphere using the new advanced instrument ALMA. To achieve this goal we intend to focus on four main objectives: analysis of large scale structures observed by ALMA, analysis of small scale structures observed by ALMA, modeling and interpretation of ALMA observations, and impact on other fields of solar physics.]]></summary_en></project><project>
<id>7790</id><title_hr><![CDATA[Neonikotinoidi i bakar u mediteranskoj poljoprivredi – učinci na neciljanu faunu beskralješnjaka kroz trofičke interakcije]]></title_hr><title_en><![CDATA[]]></title_en><user_id>12919</user_id><user_firstLast_name>Lucija Šerić Jelaska</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-6054</code><acronim><![CDATA[MEDITERATRI]]></acronim><duration>14.11.2019 - 13.11.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>28927</team_members_id><team_members_names><![CDATA[ Doktorand: Lara Ivanković ]]></team_members_names><keywords_hr><![CDATA[korisna fauna beskralješnjaka, mediteranska ekosustavi, održivo upravljanje, trofičke mreža, trčci,pauci, štrige]]></keywords_hr><keywords_en><![CDATA[Beneficial invertebrate fauna, Mediterranean ecosystems, sustainable management, trophic network, carabids, spiders, centipedes]]></keywords_en><summary_hr><![CDATA[Neonikotinoidi su relativno novi i najčešće korišteni insekticidi u svijetu. Za razliku od njih, primjena bakra (Cu) ima dugu povijest u zaštiti bilja, osobito u mediteranskoj poljoprivredi (npr. u vinogradima). Novija istraživanja su pokazala brojne negativne učinke na vrste koje nisu cilj djelovanja pesticida (npr. gujavice, ptice) i ukazala na problem očuvanja vrsta korisnih u biološkoj kontroli kao što su predatori (npr. kornjaši trčci, pauci i štrige) koji su ujedno ključni za pravilno funkcioniranje ekosustava. Velika biološka raznolikost u tlu i složene trofičke interakcije nisu dovoljno istražene i stoga je teško predvidjeti sve moguće negativne učinke pesticida. Slabo poznavanje hranidbenih lanaca kod beskralješnjaka dijelom je posljedica ograničenih mogućnosti koje nude tradicionalne metode poput mikroskopskog pregleda. Detaljne trofičke analize danas su moguće pomoću najnovijih molekularnih tehnika kao što je nova generacija sekvenciranja (NGS). Cilj ovog istraživanja je utvrditi trofičke odnose na terenu analizom probavila predatora beskralješnjaka, utvrditi vektore za prijenos pesticida putem ishrane te izravan utjecaj primjene pesticida na preživljavanje i raznolikost predatora i plijena. Terensko istraživanje obavit će se u mediteranskim poljoprivrednim ekosustavima, vinogradima i maslinicima, gdje se koriste oba pesticida, te u prirodnom staništu bez gospodarenja. NGS-om će se utvrditi kompletna ishrana predatora i ujedno će se generirati podaci o DNA sljedovima za brojne vrste beskralježnjaka koji će biti pohranjeni u bazama projekta &#39;&#39;The International Barcode of Life&#39;&#39;. LC-MS / MS i ICP-MS tehnikom kvantificirat će se ostatci neonikotinoida i izmjeriti koncentracije Cu u tlu i životinjama na različitim trofičkim razinama. Rezultati će uvelike doprinijeti procjeni rizika primjene i širenja neonikotinida i Cu u ekosustavu te znanju o održivosti  beskralješnjaka predatora kao ključne skupine u integriranoj zaštiti bilja u poljoprivredi.]]></summary_hr><summary_en><![CDATA[Neonicotinoids are the most commonly used insecticides worldwide, and are relatively new, whereas application of Copper (Cu) has a long history, especially in the Mediterranean agriculture, (e.g. in vineyards). Recent studies have shown their negative effects on non-target species (e.g. earthworms, insects, birds) and raised great concerns about survival of beneficial predatory species (e.g. carabid beetles, spiders and centipedes), important for pest control and essential for healthy ecosystem functioning. High biodiversity in the soil and very complex food webs are far from being well explored and thus it is hard to predict all possible negative effects of pesticides. This knowledge gap reflects, in part, the fact that traditional methods such as microscopic inspection cannot detect many trophic interactions. Recently, complex food web analysis has become possible with the advent of molecular techniques as Next Generation Sequencing NGS. By analysing trophic interactions of soil invertebrates, the aim is to identify vectors that transfer toxicant to general predators and to connect application of pesticides with the predator and prey survival and diversity in the field. Field survey will take place within Mediterranean agriculture ecosystems, in vineyards and olive orchards, treated with both pesticides and in pristine habitat. NGS will be used to reveal the complete diet of predatory invertebrates in the field. Besides, it will generate valuable DNA sequence data for numerous invertebrate species that will be deposited in “The International Barcode of Life“ databases. LC-MS/MS and ICP-MS technique will quantify neonicotinoid residues and Cu concentrations in soil and in animals representing different trophic guilds. The results will greatly contribute to the risk assessment of neonicotionid and copper proliferation in the ecosystem and to the knowledge on the overall field sustainability of predatory invertebrates, a key group in integrated pest control.]]></summary_en></project><project>
<id>7792</id><title_hr><![CDATA[Transformacija robota u edukacijsko sredstvo]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6592</user_id><user_firstLast_name>Ana Sović Kržić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-3733</code><acronim><![CDATA[]]></acronim><duration>06.09.2019 - 31.10.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>28856</team_members_id><team_members_names><![CDATA[ Doktorand: Ivana Storjak ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>7799</id><title_hr><![CDATA[Glikozilacija alfa kiselog glikoproteina - put prema personaliziranoj terapiji]]></title_hr><title_en><![CDATA[]]></title_en><user_id>12360</user_id><user_firstLast_name>Mario Gabričević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-2499</code><acronim><![CDATA[GlycoDrugs]]></acronim><duration>17.10.2018 - 31.03.2023</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Farmacija, </scie_field_hr><scie_field_en>Pharmaceutical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Farmaceutsko-biokemijski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Pharmacy and Biochemistry]]></institution_en><team_members_id>25302</team_members_id><team_members_names><![CDATA[ Doktorand: Robert Kerep ]]></team_members_names><keywords_hr><![CDATA[alfa kiseli glikoprotein, glikozilacija, konstanta vezanja lijeka, personalna terapija, lijekovi ]]></keywords_hr><keywords_en><![CDATA[alpha acid glycoprotein, glycosylation, drug binding constant, personally oriented therapy, drugs ]]></keywords_en><summary_hr><![CDATA[Nakon što se lijek aplicira u krv, on se najčešće u određenoj mjeri vezuje na proteine plazme. Važnost ovakvog vezanja je dobro opisana u literaturi, a udio vezanja pri ravnotežnim uvjetima određuje koncentraciju slobodnog lijeka. Slobodni udio lijeka je najčešće onaj koji je raspoloživ za aktivnost ili difuziju u okolna tkiva te se stoga samo nevezana frakcija lijeka smatra aktivnim oblikom, u skladu s “principom slobodnog lijeka”. Kao posljedica visoke koncentracije, proteini plazme kontroliraju koncentraciju slobodnog lijeka u plazmi, kao i u biološkim odjeljcima koji su s njom u ravnoteži, utječući na taj način na djelotvornost in vivo. U kliničkom smislu ovaj kapacitet treba se uzeti u obzir kad se određuje doza lijeka ili procjenjuje moguća toksičnost primijenjenog lijeka, što je obično dodatno usloženo uslijed promijena u kapacitetu proteina za vezanje lijeka kod određenih pacijenata. Izrazito glikozilirani alfa kiseli glikoprotein je jedan od dva proteina koji vežu veliki broj različitih lijekova i općenito utječu na djelotvornost lijekova. Postoje tri genetičke varijante i to F1, S i A. Vezanje lijekova za AGP može biti promijenjeno i u brojnim patološkim i fiziološkim stanjima kao rezultat promjene u glikozilacijskom uzorku. Ukupno gledano, tri faktora utječu na vezanje lijekova za AGP: Koncentracija AGP-a, omjer različitih genetičkih varijanti i promjene u glikozilacijskom uzorku. Ciljevi projekta su: 1. Kako različite genetičke varijante AGP-a utječu na ukupno vezanje lijekova? 2. Kakav je utjecaj promijenjenog glikozilacijskog uzorka na vezanje lijekova 3.  Predviđenje slobodnog udijela lijeka ovisno o navedena tri faktora. Koristit će se fizikalne metode kao fluorescencijska spektroskopija, ravnotežna dijaliza i masena spektroskopija kako bi se odredio utjecaj glikozilacijskih promjena AGP-a na vezanje lijekova i posljedično predvidio utjecaj te promjene na terapiju.]]></summary_hr><summary_en><![CDATA[After the administration of the drug to the blood stream, it often binds to a certain extent to plasma proteins. The importance of such plasma protein binding is a well recognized phenomenon and the extent of this association at equilibrium determines the concentration of unbound drug. Free fraction of the drug is most commonly the only one available for active uptake or diffusion into the surrounding tissue according to the “free drug principle”. Due to their high concentration, the plasma proteins control the free drug concentration in plasma thus influencing the drug potency in vivo. Clinically, this effect should be considered when adjusting the dosage of a drug, as well as in assessing the toxicity of the administered drug which is often complicated by changes in patient’s protein-binding capacity. Heavily glycosylated alpha-1-acid glycoprotein (AGP) is one of two proteins present in sufficient quantity to bind a broad variety of drugs and generally has a significant effect on drug action. Adding to complexity, human AGP exists as a heterogeneous population of three genetic variants namely F1, S and A. Importantly, drug binding to the AGP may be altered in numerous pathological and physiological states as a result of changes in glycosylation pattern. Overall, there are three major factors influencing binding of drugs to AGP: Concentration of AGP, ratio of different genetic forms and changes in glycosylation. Goals of this project are: 1. How different genetic forms of native AGP influence the overall drug binding? 2. What is the influence of changed glycosylation patterns of AGP on drug binding? 3. “Free drug” prediction dependent on mentioned three factors. We will use physical methods like fluorescence spectroscopy, equilibrium dialysis and MS to evaluate influence of AGP glycosylation change on drug binding and subsequently predict influence on drug therapy.]]></summary_en></project><project>
<id>7801</id><title_hr><![CDATA[Interakcija nositelj-parazit: odnos tri različita tipa nositelja prema invaziji metiljem Fascioloides magna]]></title_hr><title_en><![CDATA[Host-pathogen interaction: differences in relation between three types of hosts to Fascioloides magna infection   ]]></title_en><user_id>3919</user_id><user_firstLast_name>Dean Konjević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-8963</code><acronim><![CDATA[MAGNA]]></acronim><duration>25.10.2018 - 24.10.2022</duration><status>Završio</status><financ_value>168.305,79 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Veterinarska medicina, Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Veterinary medicine, Clinical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Veterinarski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Veterinary Medicine]]></institution_en><team_members_id>23908, 20442, 24243, 24202, 6444, 6460, 5763, 6172, 6141, 6734, 17766, 858367, </team_members_id><team_members_names><![CDATA[Eva Bazsalovicsova, Zdravko Janicki, Ivica Kralova-Hromadova, Alen Slavica, Franjo Martinković, Magda Sindičić Sindičić, Marina Pavlak, Ana Galov, Haidi Arbanasić, Josipa Kuleš, Miljenko Bujanić, Ida Svetličić, ]]></team_members_names><keywords_hr><![CDATA[Fascioloides magna, interakcija nositelj-parazit, srna obična, jelen obični, divlja svinja]]></keywords_hr><keywords_en><![CDATA[Fascioloides magna, host-parasite interaction, roe deer, red deer, wild boar]]></keywords_en><summary_hr><![CDATA[Fascioloidoza je invazijska bolest uzrokovana sa za Europu nezavičajnom vrstom dvorodnog metilja Fascioloides magna. Za sada je moguće razlikovati tri tipa konačnih divljih nositelja ovog metilja u Europi: tipični (jelen obični i lopatar), &#39;&#39;slijepa ulica&#39;&#39; (svinja divlja) i atipični (srna obična, muflon i divokoza). Iako je pojava ovog parazita potaknula razmjerno velik interes znanstvene javnosti rezultirajući objavom brojnih znanstvenih članaka, interakcije nositelj-parazit i dalje nisu razjašnjene. Pri tome je fascioloidoza atipičnih nositelja često smrtonosna bolest te je na invadiranim područjima zabilježen pad brojnosti srna. Cilj je razumijevanje interakcije nositelj-parazit u različitim tipovima nositelja. Pretpostavke projekta su: i) trajna migracija metilja kroz jetru nositelja je posljedica neadekvatnog imunosnog odgovora nositelja, i ii) trajna migracija metilja kroz jetru nositelja posljedica je nemogućnosti spolnog sazrijevanja metilja. Ciljevi projekta su: a) proučiti makroskopske i mikorskopske promjene na i u jetrima različitih tipova nositelja, b) razumjeti imunosni odgovor na metilja F. magna kod različitih nositelja, c) usporediti raznolikost/postojanje specifičnih alela MHC gena kod različitih tipova nositelja, d) analizirati različite stadije metilja kod različitih nositelja. Uzorci krvi, čitave jetre i metilji prikupit će se tijekom redovitih lovnih zahvata. Jedinke ćemo razvrstavati na negativne, invadirane, ponovno invadirane i  izliječene. Životinje s područja na kojima nije utvrđena fascioloidoza će poslužiti kao potpuno negativne kontrole. Prikupljene uzorke analizirat ćemo parazitološki, omika metodama, NGS i klasičnom analizom MHC gena, seciranjem metilja. Analize će provesti tim oformljen tijekom provedbe uspostavnog istraživačkog projekta uz pomoć članova projekta ERA Chairs  za dio proteomike. Očekujemo da će rezultati projekta pružiti odgovore o značajnim interakcijama između nositelja i parazita na primjeru fascioloidoze.]]></summary_hr><summary_en><![CDATA[Fascioloidosis is parasitic disease caused by to Europe non-native digenean trematode Fascioloides magna. For now, three different types of final hosts can be recognized in Europe: definitive (red and fallow deer), dead-end (wild boar) and aberrant (roe deer, mouflon, chamois). Despite the fact that this parasite caused significant scientific interest resulting in numerous publications, host-parasite interactions remains unclear. Since fascioloidosis in aberrant hosts often causes mortality, a decline in roe deer population was observed on infected areas. The aim is to understand the mechanisms of host-parasite interactions in different types of hosts. Project hypothesis are: i) the continuing migration of a parasite is a result of inadequate host immune response, and ii) the continuing migration of a parasite is a result of its inability to reach sexual maturation. Project goals are: a) to analyse gross and microscopic liver lesions in different types of hosts, b) to understand immune responses to F. magna in different types of host, c) to compare variability/presence of the specific alleles of the MHC genes in different types of hosts, d) to analyse different stages of the flukes in different types of hosts. Samples of blood, whole livers and flukes will be collected following regular hunting operations. Animals will be classified as negative, infected, reinfected and cured. Animals from disease free areas will be used as full negative controls. Methods applied to achieve project goals include parasitological analysis, whole proteome analysis, classical approach and NGS for exon 2 of MHC class II loci analysis, fluke dissection. The analysis will be performed by the team formed during the installation grant, strengthen by ERA Chairs member for proteomic analysis. The deliverables of the proposed project should provide answers for important host-pathogen interactions in fascioloidosis. ]]></summary_en></project><project>
<id>7802</id><title_hr><![CDATA[Signalni mehanizmi i metaboličke promjene u diferencijaciji stanica akutne mijeloične leukemije]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4677</user_id><user_firstLast_name>Dora Višnjić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-9599</code><acronim><![CDATA[SignalmetabAML]]></acronim><duration>15.09.2018 - 14.12.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>25361</team_members_id><team_members_names><![CDATA[ Doktorand: Barbara Tomić ]]></team_members_names><keywords_hr><![CDATA[signaliziranje, AMPK, diferencijacija, ciklus, leukemija]]></keywords_hr><keywords_en><![CDATA[signaling, AMPK, differentiation, cycle, leukemia]]></keywords_en><summary_hr><![CDATA[Akutna mijeloična leukemija (AML) je heterogena skupina bolesti koja je obilježena nekontroliranom proliferacijom blasta koji su zakočeni u ranoj fazi diferencijacije. Najuspješnije farmakološko liječenje AML je diferencijacijsko liječenje pomoću sve-trans-retinske kiseline (ATRA, prema engl. all-trans retinoic acid). Međutim, ATRA se rabi isključivo u liječenju akutne promijelocitne leukemije (APL),  podvrste AML koja sadrži translokaciju t(15;17). Svi ostali oblici AML liječe se intenzivnom kemoterapijom koja nije značajno povećala trajanje remisije ili opće preživljenje. Naše nedavno istraživanje pokazalo je da 5-aminoimidazol-4-karboksamid ribonukleozid (AIKAR, akadezin) potiče apoptozu i pospješuje diferencijaciju staničnih linija AML koje nisu APL, ali je mehanizam djelovanja AIKAR-a još uvijek nepoznat. Stoga je svrha predloženih istraživanja određivanje mehanizama koji su odgovorni za povoljno djelovanje AIKAR-a u stanicama non-APL AML te otkrivanje signalnih mehanizama i metaboličkih promjena koje su odgovorne za monocitnu i granulocitnu diferencijaciju stanica AML. U istraživanju ćemo rabiti komercijalne stanične linije AML da bismo opisali: a) ulogu i mehanizam autofagije u monocitno/makrofagnoj i granulocitnoj diferencijaciji, b) promjene u metabolizmu tijekom diferencijacije i prolaska kroz stanični ciklus, te c) ulogu deacetilaza Sirt u monocitno/makrofagnoj i granulocitnoj diferencijaciji staničnih linija AML. Dodatno, ispitat ćemo učinke AIKAR-a in vitro na uzorcima blasta izoliranih iz oboljelih od AML. Istraživanja signalnih mehanizama odgovornih za diferencirajući učinak u leukemijskim stanicama mogu u konačnici pridonijeti uspješnijem liječenju oboljelih od AML.]]></summary_hr><summary_en><![CDATA[Acute myeloid leukemia (AML) is a heterogeneous group of diseases characterized by clonal proliferation of blasts that are blocked at an early stage of differentiation. The most successful pharmacological therapy of AML is differentiation therapy with all-trans-retinoic acid (ATRA); however, ATRA-based therapy is restricted to acute promyelocytic leukemia (APL), a particular subtype that carries t(15;17) translocation. All other AMLs are treated with intensive chemotherapy, which have not significantly improved the disease-free or overall survival. Our recent study demonstrated that 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR, acadesine) induces apoptosis and enhances differentiation of non-APL AML cell lines, but the mechanism is still unknown. Therefore, proposed studies are aimed to determine the mechanism responsible for beneficial effects of AICAR in non-APL AML cells and to further elucidate signaling mechanisms and metabolic changes responsible for monocytic and granulocytic differentiation of AML cells. We will use commercially available AML cell lines to define: a) the role and the mechanism of autophagy in monocytic/macrophage and granulocytic differentiation, b) the changes in metabolism during differentiation and cell cycle progression, and to determine c) the role of Sirt deacetylase in monocytic/macrophage and granulocytic differentiation of AML cell lines. In addition, in vitro profiling of the sensitivity of primary AML samples to AICAR will be performed. The proposed project aims to define signaling mechanisms responsible for differentiation of leukemia cells, which may eventually lead to the development of an improved therapy, thus contributing to well-being of AML patients.]]></summary_en></project><project>
<id>7807</id><title_hr><![CDATA[Racionalnost: između logičkog ideala i svakodnevnog zaključivanja ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>2681</user_id><user_firstLast_name>Nenad Smokrović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-2832</code><acronim><![CDATA[RACIO]]></acronim><duration>16.07.2018 - 15.09.2020</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filozofija, </scie_field_hr><scie_field_en>Philosophy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Filozofski fakultet u Rijeci]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>23262</team_members_id><team_members_names><![CDATA[ Doktorand: David Grčki ]]></team_members_names><keywords_hr><![CDATA[racionalnost, logika, zaključivanje, prirodni jezik, argumentacija, kritičko mišljenje]]></keywords_hr><keywords_en><![CDATA[rationality, logic, reasoning, natural language, argumentation, critical thinking]]></keywords_en><summary_hr><![CDATA[Opći je cilj projekta odrediti narav i značajke racionalnosti shvaćene kao kriterij ispravnog zaključivanja. Područje istraživanja čini prostor između jakog normativnog standarda racionalnosti određenog formalnim logičkim pravilima i istraživanja koja nastoje izvesti norme zaključivanja na temelju stvarnog ponašanja ljudi pri rješavanju deduktivnih zadataka. Fokus istraživanja oslanja se na logicistički pristup racionalnosti koji će biti podvrgnut provjeri s obzirom na ponašanje subjekata prilikom svakodnevnog zaključivanja.Kako bi se ostvario taj cilj istraživačke su aktivnosti usmjerene na istraživanja vezana uz četiri teme:1) Prirodni jezik kao medij za deduktivno zaključivanje. Ako su logička pravila barem djelomično normativna za ispravno zaključivanje, važan je podcilj istražiti mogućnosti izražavanja i zrcaljenja logičkih operatora u prirodnome jeziku.2) Uloga individualnih razlika u svakodnevnom zaključivanju. Istaknuta je značajka svakodnevnoga zaključivanja da subjekt zahvaća deduktivni problem u skladu s onim kako ga razumije, stoga je moguća aktivacija različitih mehanizama zaključivanja. Prihvatljivost ove hipoteze značajno će utjecati na raspravu o postojanju jedinstvenog standarda racionalnosti.3) Racionalnost u kontekstu društvenih interakcija, posebno u argumentacijskom procesu. Argumentacijski je proces bitno određen oblikovanjem i procjenjivanjem argumenata, što od sudionika zahtijeva dijeljenje istih komunikacijskih i deduktivnih pravila.4) Pitanje kritičkoga mišljenja određuje područje istraživanja u kojem će sva ranije spomenuta pitanja biti sažeta, analizirana i testirana u kontekstu različitih područja svakodnevnoga života te će dobiveni rezultati poslužiti za formuliranje regulativnih uputa za moguće unaprjeđenje vještina kritičkoga mišljenja.Najznačajnijim se doprinosom projekta može smatrati pokušaj određenja dobro usklađenog standarda racionalnosti smještenog između ideala logičkih pravila i prakse svakodnevnoga zaključivanja.]]></summary_hr><summary_en><![CDATA[The overall goal of the project is to determine the nature and characteristics of rationality understood as a criterion of correct reasoning. The research area is the space between a strong normative standard of rationality determined by formal logical rules and researches that strive to derive norms of reasoning from the actual people’s behavior in solving deductive tasks. The focal point of the investigation relies on the logistic approach to rationality to be tested against subjects’ behavior in everyday reasoning.To reach this goal, research activities will be focused on investigations in four topics:1) Natural language as a media for deductive reasoning. If logical rules are at least partly normative for correct reasoning, the important sub-goal is to investigate natural language’s possibilities to express and mirror logical terms.2) The role of individual differences in everyday reasoning. The salient feature of everyday reasoning is that the subject responds to a deductive problem as he/she understands it, so the activation of a variety of reasoning mechanisms is possible. If this hypothesis can be confirmed, it will significantly contribute to the debate concerning uniqueness or plurality of the rationality standard(s). 3) The rationality of social interactions, particularly in the argumentative process. The argumentative process is determined by the making and assessing of arguments, which requires a mutual recognition of communicative and deductive rules. 4) The issue of critical thinking determines the investigation area in which all mentioned questions could be summarized, analyzed and tested in various fields of everyday life and the obtained results will be used to enable the articulation of prescriptions for a possible improvement of critical thinking skills. The most important contribution of the project can be seen as an attempt to determine the well-balanced standard of rationality placed between ideal logical rules and everyday reasoning practice.]]></summary_en></project><project>
<id>7809</id><title_hr><![CDATA[Genomske i epigenomske promjene u auto- i alopoliploidima na modelu dalmatinskog buhača, ljutike i anemona]]></title_hr><title_en><![CDATA[]]></title_en><user_id>19769</user_id><user_firstLast_name>Višnja Besendorfer</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-9358</code><acronim><![CDATA[AutoAloPol]]></acronim><duration>10.10.2018 - 15.11.2023</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>25319</team_members_id><team_members_names><![CDATA[ Doktorand: Adela  Jurković ]]></team_members_names><keywords_hr><![CDATA[autopoliploidija, alopoliploidija, genomika, epigenomika, evolucija biljnog genoma]]></keywords_hr><keywords_en><![CDATA[autopolyploidy, allopolyploidy, genomic, epigenomic, plant genome evolution]]></keywords_en><summary_hr><![CDATA[Poliploidija/udvostručavanje genoma glavni je pokretački mehanizam specijacije i bioraznolikosti biljaka koji dovodi do stvaranja novih genetičkih varijanti, pokreće evoluciju, povećava genetičku raznolikost organizama te ima veliku ulogu u domestikaciji biljaka. Iako su rađena brojna istraživanja još uvijek se malo zna o promjenama koje se događaju na razini genoma nakon poliploidizacije i hibridizacije. Auto- i alopoliploidija dovodi do nestabilnosti i reorganizacije genoma. Nepravilna segregacija kromosoma u mejozi glavni je problem za formiranje funkcionalnih gameta i uspješnog spolnog razmnožavanja novosintetiziranih autopoliploida. Evolucijski stari autopoliploidi razvili su mehanizme koji su s vremenom osigurali pravilnu segregaciju kromosoma. Točan mehanizam prelaska iz nestabilnog u stabilno stanje genoma nakon poliploidizacije još je nerazjašnjeno. Ovim projektom istražit će se mejotski procesi koji dovode do pravilne segregacije kromosoma i ekspresija gena uključenih u sparivanje kromosoma/homolognu rekombinaciju u autotetraploidu dalmatinskog buhača (T. cinerariifolium). Stabilizacija mejoze kroz mali broj generacija važna je za komercijalnu proizvodnju autotetraploida. Genomi alopoliploidnih vrsta izuzetno su dinamični zbog interakcija između subgenoma koje dovode do homogenizacije alopoliploida. Homogenizacija se odvija kroz genomske rearanžmane (inverzije, translokacije, trasnpozicije) i delecije dijelova genoma u koje su najčešće uključene ponavljajuće DNA kao i promjene u metilaciji DNA. Ovim projektom žele se na razini genoma i epigenoma utvrditi koji mehanizmi i u kojoj mjeri su uključeni u reorganizaciju genoma sterilne alotriploidne ljutike (A. × cornutum), fertilne alotetraploidne vrste A. multifida i aloheksaploidne A. baldensis. Istraživanja predložena ovim projektom pružit će bolji uvid u promjene na razini genoma i epigenoma u vrstama važnim za ljudsku prehranu, ekološku poljoprivredu i proizvodnju novih hortikulturnih varijanti.]]></summary_hr><summary_en><![CDATA[Polyploidy/genome duplication is the main mechanism of speciation and biodiversity in plants, drives evolution, increases genetic diversity and organism complexity, and plays an important role in domestication of plants. Although numerous studies have been conducted so far, we still don’t know enough about the genomic changes that are taking place after polyploidization and hybridization. Auto- and allopolyploidy lead to genome instability and reorganization. Improper chromosome segregation in meiosis is the main problem for functional gamete formation and successful sexual reproduction in neo-autopolyploids. Evolutionary old autopolyploids have developed mechanisms that lead to proper chromosome segregation but the exact mechanism of transition from unstable to stable genome condition after polyploidization is not fully understood. This project will study meiotic processes that lead to the proper chromosome segregation as well as gene expression involved in chromosome pairing/homologous recombination in autotetraploid pyrethrum (T. cinerariifolium). Stabilization of meiosis through a few generations is important for commercial production of autotetraploids. Genomes of allopolyploid species are extremely dynamic in terms of their subgenome interactions that lead to their homogenization. Homogenization is carried out through genomic rearrangements (inversions, translocations, transposition) and partial genome (rich in repetitive DNA) deletions as well as changes in DNA methylation. With this project we want to determine the mechanisms at the genome and the epigenome level which are involved in reorganization of subgenomes in sterile allotriploid shallot (A. x cornuntum) and fertile allotetraploid A. multifida and allohexaploid A. baldensis. The research proposed in this project will provide a better insight into changes at the genomic and epigenomic level in species important for human consumption, organic farming and the production of new horticultural varieties.]]></summary_en></project><project>
<id>7810</id><title_hr><![CDATA[Razlaganje električnim poljem u tankim optičkim slojevima - nanostrukturiranje, dopiranje, porozni slojevi]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1019</user_id><user_firstLast_name>Vesna Janicki</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-3956</code><acronim><![CDATA[REPTOSNANODOPS]]></acronim><duration>01.11.2018 - 31.12.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>25344</team_members_id><team_members_names><![CDATA[ Doktorand: Petar Pervan ]]></team_members_names><keywords_hr><![CDATA[tanki slojevi, dopiranje, razlaganje električnim poljem, Li-ion tankoslojne baterije, porozni slojevi, metalne nanočestice, nanostrukturiranje]]></keywords_hr><keywords_en><![CDATA[thin films, doping, electric field assisted dissolution, Li-ion thin film batteries,  porous layers,  metal nanoparticles, nanostructuring]]></keywords_en><summary_hr><![CDATA[Proces izmjene metalnih iona se koristi već stotinama godina u proizvodnji obojenih stakala. Kao izvor metalnih iona može se koristiti sloj metala u čvrstom stanju. Da bi se ubrzala difuzija primjenjuje se umjereno zagrijavanje i električno polje. Istraživanja su pokazala da u ovakvim uvjetima dolazi do razlaganja metalnih nanočestica (NČ) uronjenih u staklo, dielektrični tanki sloj ili višeslojni sustav. Ovaj proces je poznat kao razlaganje električnim poljem (EFAD - electric field assisted dissolution). Ovaj proces ima nekoliko zanimljivih efekata. Primjenom EFAD-a na NČ uronjene u dielektričnu matricu, u njoj ostaju šupljine - pore. Razlaganjem metalnih NČ primjenom strukturirane elektrode, uzorak s elektrode se preslikava na sistem s metalnim NČ. Zagrijavanjem podloge dopirane metalnim ionima u njoj se formiraju NČ. Nedavno je pokazano da metal ponovno izlazi na površinu zagrijavanjem u atmosferi vodika, formirajući inverzni uzorak onome strukturirane primijenjene elektrode. Navedeno pokazuje brojne mogućnosti EFAD-a: dopiranje, formiranje poroznih slojeva i restrukturiranje. No, unatoč velikom potencijalu EFAD-a, znanstvene aktivnosti koje ga uključuju nisu brojne, te ostaju na nivou baznih istraživanja, s primjenom samo za pripremu nanokompozitnog stakla s Ag NČ. Ovim projektom bi se sistematično istražio EFAD kao metoda dopiranja i izrade poroznih slojeva. Projekt se ne bi ograničio samo na bazna istraživanja. Postignute spoznaje bi se primijenile za poboljšanje karakteristika punjivih litijskih tankoslojnih baterija i izradu nanostruktura reverznim restrukturiranjem. Radi znatnog potencijala EFAD-a, dio vremena i resursa će se posvetiti i ostalim mogućim primjenama.]]></summary_hr><summary_en><![CDATA[The ion exchange process has been used for hundreds of years in production of stained glass windows. A solid metal film can be used as the dopant source. Moderate annealing and electric field are applied to enhance the penetration of dopant ions. Recent research has shown that these conditions enable the dissolution of metal nanoparticles (NP), whether they are embedded in glass, dielectric thin film or multilayer system. This process in known as electric field assisted dissolution (EFAD). It opens many different possibilities. EFAD applied to NP embedded in dielectric matrix results in pores remaining on the positions of NP. If structured electrode is applied to NP containing system, the pattern from the electrode is copied onto the system. By annealing a metal ion doped substrate, metal NP form in the substrate. Very recent research has shown that annealing in hydrogen atmosphere makes metal ions diffuse to the surface, forming pattern inverse to the one of the applied electrode. All of this presents numerous possibilities of EFAD: doping, porous layers formation and restructuring. However, despite of EFAD great potential, scientific activities involving this process remain modest, at the level of a fundamental research and applied only for Ag NP nanocomposite glass preparation. This project will systematically study EFAD as a method for doping of different kinds of substrates and for preparation of porous layers. The project will not be limited merely to fundamental research. The obtained results will be applied to improve characteristics of rechargeable thin film lithium batteries and fabrication of nanostructures by reverse restructuring. Due to the significant potential of EFAD, part of time and resources will be devoted to the other applications as well. ]]></summary_en></project><project>
<id>7811</id><title_hr><![CDATA[Fizičko modeliranje ponašanja konstrukcija za sanaciju klizišta u uvjetima statičkih i seizmičkih djelovanja]]></title_hr><title_en><![CDATA[Physical modelling of landslide remediation constructions behaviour under static and seismic actions]]></title_en><user_id>20171</user_id><user_firstLast_name>Željko Arbanas</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-1503</code><acronim><![CDATA[ModLandRemSS]]></acronim><duration>01.10.2018 - 30.09.2022</duration><status>Završio</status><financ_value>131.992,83 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Građevinarstvo, </scie_field_hr><scie_field_en>Civil engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Građevinski fakultet u Rijeci]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Civil Engineering]]></institution_en><team_members_id>4285, 23421, 23427, 13520, 23429, 19011, 28704, 866215, </team_members_id><team_members_names><![CDATA[Vedran Jagodnik, Sanja Dugonjić Jovančević, Martina Vivoda, Petra Đomlija, Josip Peranić, Nina Čeh, Sara Pajalić, Davor Marušić, ]]></team_members_names><keywords_hr><![CDATA[klizište, fizički model, modeliranje, sanacija, konstrukcija, monitoring]]></keywords_hr><keywords_en><![CDATA[landslide, physical model, modelling, remediation, structure, monitoring]]></keywords_en><summary_hr><![CDATA[Fizičko modeliranje klizišta na temelju analiza ponašanja umanjenih modela započeto je krajem 1980-tih kad je istraživano ponašanje tokova tla i fluidifikacije kliznog materijala u umanjenom fizičkom modelu (također poznatom pod nazivom flume ili flume test). Glavni zadatak fizičkog modeliranja klizišta u zadnjih 25 godina bilo je istraživanje pokretanja, kretanja i akumulacije brzih klizišta nalik tečenju uzrokovanih infiltracijom vode u kosinu. Brojni modeli klizišta i istraživanja mogu se podijeliti u dvije glavne grupe vezane na osnovne pokretače klizišta: oborine i potrese. Postojeće studije ponašanja sanacijskih konstrukcija na klizištima u fizičkim modelima vrlo su rijetke. Predloženi Projekt uključiti će istraživanja ponašanja različitih konstrukcije primijenjenih za sanacije klizišta u fizičkim modelima umanjenih klizišta u statičkim i dinamičkim uvjetima gdje statički uvjeti pretpostavljaju uvjete klizišta pokrenutih oborinama, a dinamički uvjeti uvjete klizišta izazvanih potresima. Promatranje gibanja u fizičkom modelu klizišta provesti će se mrežom senzora za mjerenje pomaka, pritisaka, sila i pornih pritisaka i inovativnom fotogrametrijskom opremom koja uključuje terestrički laserski skener i infracrvenu kameru. Umanjene sanacijske konstrukcije izraditi će se 3D printerom što će omogućiti precizne umanjene elemente konstrukcija. Izmjereni parametra iz fizičkog modela biti će uključeni u 3D numeričke simulacije. Rezultati iz oba modela omogućiti će bolje razumijevanje ponašanja konstrukcija za sanaciju klizišta. Metode analiza stabilnosti koje se koriste za projekte sanacije klizišta u inženjerskoj praksi još uvijek su grube i rezultiraju odabirom konzervativnih sanacijskih konstrukcija. Zbog tog razloga, rezultati istraživanja mogli bi predstavljati osnovu za nove pristupe racionalnog projektiranja sanacijskih konstrukcija za klizišta u inženjerskoj praksi.]]></summary_hr><summary_en><![CDATA[Physical modelling of landslide using scaled landslide models behaviour was established at the end of 1980s when in a scaled physical model (flume or flume test) behaviour of flowslide and liquefaction of sliding material were investigated. The main task of landslide physical modelling in last 25 years was research of initiation, motion and accumulation of fast flow like slides caused by infiltration of surface water in a slope. The numerous established landslide physical models and researches can be divided in two main groups related to landslide main triggering factors: rainfall and earthquakes. The existing studies of landslide remedial construction behaviour using physical modelling are very rare. The proposed Project will encompass researches of behaviour of different construction applied for landslide remediation in physical models of scaled landslides in static and dynamic conditions where static conditions imply conditions for rainfall triggered landslides and dynamic conditions imply conditions for earthquake induced landslides. Observations of landslide movements in a physical model will be carried out by sensor network for measuring displacements, pressures, forces and pore pressures and innovative photogrammetric equipment including terrestrial laser scanner and infrared camera. Scaled remedial constructions will be constructed by 3D printer that will enable precise scaled construction elements. The measured parameters from physical model will be included in 3D numerical simulation. The results of both physical and numerical modelling will enable better understanding of landslide remedial construction behaviour. Methods of stability analysis used for landslide remediation design in engineering practice are still very rough and result with selection of conservative remedial constructions. For that reason, research results would represent the base for new approaches to the rational landslide remedial construction designing in engineering practice.]]></summary_en></project><project>
<id>7812</id><title_hr><![CDATA[Rasvjetljivanje onkogenih funkcija E6/E7 HPV-a na različitim anatomskim mjestima ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>15915</user_id><user_firstLast_name>Vjekoslav Tomaić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-2852</code><acronim><![CDATA[HPVHNC]]></acronim><duration>05.10.2018 - 31.12.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>25278</team_members_id><team_members_names><![CDATA[ Doktorand: Lucija Lulić ]]></team_members_names><keywords_hr><![CDATA[HPV, Karcinom, Glava i Vrat, E6, E7]]></keywords_hr><keywords_en><![CDATA[HPV, Cancer, Head and Neck, E6, E7 ]]></keywords_en><summary_hr><![CDATA[Humani papiloma virusi (HPV) uzrokuju preko 600.000 novih slučajeva raka godišnje na različitim anatomskim mjestima. Najčešća sijela raka uzrokovanog HPV-om su anogenitalno područje te glava i vrat. Najvažniji tip tumora uzrokovan HPV-om je rak vrata maternice, koji je jedan od glavnih uzroka smrti od tumora žena diljem svijeta. HPV-i kodiraju dva onkoproteina, E6 i E7 koji su direktno odgovorni za tumorigenezu. Ovi onkoproteini ciljaju različite signalne puteve stanice domaćina vezane uz kontrolu staničnog ciklusa i apoptozu te su trajno potrebni za proces tumorigeneze. Ukoliko se bilo koji od njih prestane ispoljavati, dolazi do prestanka rasta transformiranih stanica. Stoga ovi proteini predstavljaju značajne mete za eventualne terapije, a detaljno razumijevanje molekularnih mehanizama njihovog funkcioniranja je od iznimne važnosti. U zadnjih nekoliko godina je zamijećen trend porasta učestalosti nekih od HPV-povezanih tipova tumora, pogotovo u regiji glave i vrata. Ovi tumori većinom sadrže HPV tip 16, a karakterizira ih relativno kraće vrijeme između infekcije i nastanka tumora u odnosu na anogenitalne tumore. Ovo upućuje na postojanje značajnih razlika u mehanizmima nastanka tumora na različitim anatomskim mjestima. Jedan od glavnih ciljeva ovog projekta će biti otkriti da li su spomenute razlike posljedica različitih interakcija virusa i domaćina u različitim anatomskim mjestima. ]]></summary_hr><summary_en><![CDATA[Human Papillomaviruses (HPVs) cause over 600,000 cancers annually. These occur at diverse anatomical sites, and include anogenital and head and neck (HN) cancers. Of these the most important is cervical cancer, which is the leading cause of cancer-related death in women in many parts of the world. HPVs encode two oncoproteins, E6 and E7 that are directly responsible for the development of HPV-induced malignancies. They do this cooperatively by targeting diverse cellular pathways involved in the regulation of cell cycle control and apoptosis. Most importantly, there is a continued requirement for E6 and E7 expression throughout tumourigenesis, with loss of either protein resulting in a cessation of transformed cell growth. Therefore these viral proteins represent excellent targets for therapeutic intervention and understanding the molecular mechanisms underlying their respective functions is critical for developing such antiviral therapies. In recent years there has been dramatic increase in the number of HPV-associated cancers at other anatomical sites, especially in the HN region. Cancers found in this area largely contain HPV-16 sequences and the time frame between initial infections and cancer progression is much shorter in comparison with the anogenital cancers, indicating potentially major differences in how these viruses induce cancer development at different anatomical sites. Determining if this is a reflection of different modes of virus-host interactions in these sites will be the main focus of this project.]]></summary_en></project><project>
<id>7813</id><title_hr><![CDATA[Eksperimentalna i klinička istraživanja hipoksijsko-ishemijskog oštećenja mozga u perinatalnoj i odrasloj dobi (KK.01.1.1.01.0007) ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5255</user_id><user_firstLast_name>Aleksandra Dugandžić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-9597</code><acronim><![CDATA[]]></acronim><duration>29.10.2018 - 30.11.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>25363</team_members_id><team_members_names><![CDATA[ Doktorand: Martina Ratko ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>7814</id><title_hr><![CDATA[Patogeni potencijal Virusa uvijenosti lista vinove loze 3 i njegova interakcija s domaćinskim biljkama]]></title_hr><title_en><![CDATA[Pathogenic potential of Grapevine leafroll-associated virus 3 and its interaction with grapevine hosts]]></title_en><user_id>3236</user_id><user_firstLast_name>Katarina Hančević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-9622</code><acronim><![CDATA[GRAPE-PATH3]]></acronim><duration>01.01.2019 - 31.12.2022</duration><status>Završio</status><financ_value>99.024,49 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, Biotehnologija, Interdisciplinarne biotehničke znanosti, </scie_field_hr><scie_field_en>Agriculture, Biotechnology, Interdisciplinary biotechnical sciences, </scie_field_en><institution_hr><![CDATA[Institut za jadranske kulture i melioraciju krša]]></institution_hr><institution_en><![CDATA[Institute for Adriatic Crops and Karst Reclamation in Split]]></institution_en><team_members_id>2795, 2826, 22737, 3387, 12462, 23869, 23818, 1507, 26106, </team_members_id><team_members_names><![CDATA[Ana Mucalo, Tomislav Radić, Silvija Černi, Sandra Radić Brkanac, Matevž Likar, Marjana Regvar, Pasquale Saldarelli, Goran Zdunić, Mate Čarija, ]]></team_members_names><keywords_hr><![CDATA[vinova loza, GLRaV-3,biološko indeksiranje, molekularna karakterizacija, fiziološki biljni odgovor ]]></keywords_hr><keywords_en><![CDATA[grapevine, GLRaV-3, biological indexing, molecular characterization, physiological plant responses]]></keywords_en><summary_hr><![CDATA[Bolest uvijenost lista vinove loze (GLD) jedna je od najznačajnijih virusnih bolesti vinove  loze, a virus uvijenosti lista vinove loze 3 (GLRaV-3) jedan je od glavnih uzročnika te bolesti. Istraživanja vezana za GLRaV-3 uglavnom su usmjerena na proučavanje epidemiologije bolesti i razvoja pouzdanih metoda detekcije, dok je uloga različitih genetičkih varijanti GLRaV-3 u GLD etiologiji i odgovor biljke na prisutnost ovog virusa u velikoj mjeri nepoznat. Glavni cilj ovog projekta je dijagnosticirati i bolje razumjeti promjene koje visoko patogeni virus GLRaV-3 uzrokuje u osjetljivim domaćinskim biljkama in vivo. Napraviti će se pregled distribucije ekonomski štetnih virusa vinove loze u autohtonim kultivarima vinove loze južne Hrvatske s posebnim osvrtom na GLRaV-3 i njegove genetske varijante. Varijante čistih sojeva ovog virusa prisutne u jadranskim vinogradima, kao i njihove kombinacije molekularno će se okarakterizirani koristeći PCR i SSCP metode te će se biološki okarakterizirati na setu bezvirusnih indikatorskih biljaka. Koristit će se tri biološke indikatorske vrste koje intenzivno razvijaju simptome GLRaV infekcije i stoga su najbolji domaćini za otkrivanje morfoloških, fizioloških i biokemijskih promjena koje ovaj virus uzrokuje. Odgovori domaćina promatrat će se preko promjena u sastavu nutrienata, promjena hormonskog statusa, enzimskih aktivnosti uključenih u stresna stanja, fotosinteze i transpiracije, sadržaja klorofila, permeabilnosti membrane i sadržaja vode. Posebna pažnja posvetit će se interakciji virusa i odabranih domaćinskih biljaka kroz dinamiku virusne replikacije u biljkama domaćina tijekom procesa infekcije metodom real-time RT-PCR. Dobiveni rezultati omogućit će bolje razumijevanje patogenog potencijala čistih varijanti GLRaV-3 i njihovih kombinacija te posljedica koje ovaj virus ima na autohtone sorte vinove loze s jadranskog područja, osim već dobro proučenih vidljivih simptoma uvijenosti lista. ]]></summary_hr><summary_en><![CDATA[Grapevine leafroll disease (GLD) is one of the most important grapevine viral diseases, with the Grapevine leafroll-associated virus-3 (GLRaV-3) being one of its main causal agents. Research on GLRaV-3 has been largely focused on epidemiology and the development of reliable detection assays while the role of different genetic variants of GLRaV-3 in GLD aetiology and consequent plant response is largely unknown. The main objective of this study is to diagnose and better understand changes that highly pathogenic GLRaV-3 induce in susceptible hosts’ plant in vivo. Distribution screening in autochthonous grapevine cultivars of Southern Croatia will be performed with special attention to GLRaV-3 and its genetic variants. Pure variants present in Adriatic vineyards as well as their combinations molecularly determined by PCR and SSCP methods will be biologically characterised on the set of virus-free indicator plants. Three biological indicators of GLD are the most sensitive woody species that strongly develop symptoms of GLRaV-3 infection and thus are the best hosts to detect morphological, physiological and biochemical changes this virus causes. Host responses will be observed via changes in nutrient status, hormonal statuses, enzyme activity involved in scavenging stressed condition, photosynthetic and transpiration rates, chlorophyll content, membrane permeability and water content. Special attention will be paid on the interaction between virus and host plants by exploring the dynamic of virus replication throughout the infection processes examined by real-time RT-PCR. Obtained results will enable deeper understanding of the pathogenic potential of GLRaV-3 pure strains and their combinations and the consequences on the autochthonous grapevine cultivars from the Adriatic coast, apart from the well-studied visible symptoms. ]]></summary_en></project><project>
<id>7816</id><title_hr><![CDATA[Uloga stresnog proteina Hsp70 u imunosno-upalnom odgovoru kod kronične opstrukcijske plućne bolesti]]></title_hr><title_en><![CDATA[]]></title_en><user_id>12345</user_id><user_firstLast_name>Lada Rumora</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-7947</code><acronim><![CDATA[Hsp70COPD]]></acronim><duration>05.07.2018 - 04.07.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Farmacija, </scie_field_hr><scie_field_en>Pharmaceutical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Farmaceutsko-biokemijski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Pharmacy and Biochemistry]]></institution_en><team_members_id>25103</team_members_id><team_members_names><![CDATA[ Doktorand: Iva Hlapčić ]]></team_members_names><keywords_hr><![CDATA[Hsp70, KOPB, upala, TLR, NLRP3 inflamasom, signalne molekule, stanično umiranje, biomarkeri]]></keywords_hr><keywords_en><![CDATA[Hsp70, COPD, inflammation, TLR, NLRP3 inflammasome, signalling molecules, cell death, biomarkers]]></keywords_en><summary_hr><![CDATA[Kroničnu opstrukcijsku plućnu bolest (KOPB) karakterizira stalno ograničenje protoka zraka koje je povezano s pojačanom kroničnom upalom.Glavna hipoteza ovog istraživanja je da je pojačan imunosno-upalni odgovor posljedica povišenih koncentracija izvanstaničnog Hsp70 (eHsp70) u bolesnika s KOPB-om.Cilj in vitro istraživanja ispitati je mehanizam djelovanja eHsp70 na plućnim i krvnim stanicama. Stoga će se pratiti aktivacija TLR2 i TLR4 receptora, NLRP3 inflamasoma i signalnih molekula MAPK i NF-kappaB, koje potiču otpuštanje upalnih citokina (TNFalpha, IL-6, IL-1alpha, IL-1beta). Kako bi se razjasnilo funkcionalno značenje aktivacije navedenih molekula, koristit će se specifični agonisti, antagonisti i inhibitori. Također će se istraživati citotoksičnost eHsp70 te će se proučiti različiti načini umiranja stanica (apoptoza, nekroptoza, piroptoza).Cilj ex vivo istraživanja ispitati je povezanost eHsp70 i drugih upalnih parametara s klinički značajnim ishodima KOPB-a. Predloženo istraživanje longitudinalno je praćenje sistemskih upalnih biomarkera u skupinama bolesnika u stabilnoj fazi KOPB-a te zdravih ispitanika (pušača i nepušača). Spirometrijska mjerenja vršit će se jednom godišnje tijekom tri godine, a krv će se vaditi na početku istraživanja i nakon godine dana. Genska komponenta bolesti istražit će se ispitivanjem ekspresije (RT-qPCR) i polimorfizama (PCR-RFLP) gena za Hsp70, TLR2 i TLR4. Sistemska upala ispitat će se određivanjem upalnih DAMP molekula (eHsp70, eATP, IL-1alpha), citokina (TNFalpha, IL-6, IL-1beta) te općih upalnih biomarkera (leukociti, CRP, fibrinogen).Smatramo da će rezultati ovog istraživanja doprinijeti boljem razumijevanju sistemskog upalnog fenotipa u KOPB-u te da će pripomoći individualizaciji terapijskog pristupa kao i poboljšanju značajnih kliničkih ishoda KOPB-a.]]></summary_hr><summary_en><![CDATA[Chronic obstructive pulmonary disease (COPD) is characterized by persistent airflow limitation associated with an enhanced chronic inflammation.Main hypothesis of our research is that strong activation of immune and inflammatory responses is result of increased levels of extracellular Hsp70 (eHsp70) in COPD patients.The objective of in vitro investigations is to explore underlying mechanisms of eHsp70 effects in pulmonary and peripheral blood cells. Therefore we will monitor activation of TLR2 and TLR4 receptors, NLRP3 inflammasome, and signalling molecules MAPKs and NF-kappaB, important for pro-inflammatory cytokines release (TNFalpha, IL-6, IL-1alpha, IL-1beta). To elucidate the functional significance of molecules’ activation in eHsp70-induced inflammation, we will use specific agonists, antagonists and inhibitors. We will also explore eHsp70 cytotoxicity and differentiate between various modes of cell death (apoptosis, necroptosis, pyroptosis).The objective of ex vivo investigations is to associate eHsp70 and other pro-inflammatory parameters with clinically relevant COPD outcomes. The proposed study provides longitudinal investigations of systemic inflammatory biomarkers in stabile COPD patients, and smoking and non-smoking controls. Spirometry measurements will be performed annually during three year follow up, and blood will be collected at the recruitment and after one year. Genetic component of the disease will be explored by assessing expression (RT-qPCR) and polymorphisms (PCR-RFLP) of Hsp70, TLR2 and TLR4 genes. Systemic inflammation will be evaluated by pro-inflammatory DAMPs (eHsp70, eATP, IL-1alpha), cytokines (TNFalpha, IL-6, IL-1beta) and general biomarkers (leukocytes, CRP, fibrinogen) determination.We believe that obtained results will provide new information on the systemic inflammatory COPD phenotype, which might help to individualize therapeutic strategy, and to improve relevant clinical outcomes of the disease.]]></summary_en></project><project>
<id>7817</id><title_hr><![CDATA[Priobalna rastilišta: obrasci i procesi demografske varijabilnosti morskih riba uzduž istočnojadranske obale]]></title_hr><title_en><![CDATA[]]></title_en><user_id>2707</user_id><user_firstLast_name>Sanja Matić-Skoko</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-2092</code><acronim><![CDATA[NurseFish]]></acronim><duration>01.08.2018 - 01.02.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut za oceanografiju i ribarstvo]]></institution_hr><institution_en><![CDATA[Institute of Oceanography and Fisheries]]></institution_en><team_members_id>19894</team_members_id><team_members_names><![CDATA[ Doktorand: Dario Vrdoljak ]]></team_members_names><keywords_hr><![CDATA[rastilište, nedorasle ribe, selidba, novačenje, otolit, geokemija, obala, estuarij]]></keywords_hr><keywords_en><![CDATA[nursery grounds, juvenile fish, settlement, recruitment, otolith, geochemistry, coast, estuary]]></keywords_en><summary_hr><![CDATA[Nažalost, mnoga priobalna staništa su pod povećanim okolišnim i antropogenim pritiscima i postoji  nedostatak saznanja o uzročno-posljedičnim odnosima tih pritisaka na morski ekosustav. Međutim, utvrđivanje takvih odnosa između širokog raspona stresnih čimbenika i njihovih učinaka na razini jedinke, vrste ili zajednice u morskom ekosustavu, je vrlo težak zadatak.Estuariji i priobalna područja se uobičajeno smatraju za visoko produktivne i vrijedne ekosustave. Istaknuta je njjihova uloga kao rastilišta za rane razvojne stadije mnogih vrsta. No, postoje  nejasni dokaz o važnosti obilježja staništa u u oblikovanju obrazaca dinamike populacija riba. Stoga, glavni istraživački ciljevi ovog projekta su šira prostorna procjena rastilišta riba uzduž obale srednjeg Jadrana, prostorno-vremenski trendovi u strukturi nedoraslih ribljih zajednica u rastilištima s međugodišnjom varijabilnosti u gustoći nedoraslih i jačine godišnje klase za određene gospodarski važne vrste riba; povezanost između estuarijskih i prioobalnih staništa preko elementarnih geokemijskih otisaka otolita  koji ukazuju na gibanja riba i vremensku konzistenciju individualnog doprinosa svakog pojedinog rastilišta obalnim područjima/populacijama riba. Također, analizirat će se vremenske promjene u strukturi nedoraslih ribljih zajednica unutar dva desetljeća s osnovnim matricama raznolikosti koje karakteriziraju promjene u taksonomskom sastavu zajednice kroz vrijeme, utvrđivanje da li je došlo do povećanja termofilnih vrsta i eventualno veća učestalost pelagičnih vrsta kako bi se osigurali dokazi za moguće faunističke promjene.Istraživanja u okviru predloženog projekta provodit će se duž istočne obale srednjeg Jadrana primjenom suvremenih metoda terenskog rada i analize. Projektni tim će izgraditi nove istraživačke kapacitete, a rezultati projekta u potpunosti će biti primjenjivi u upravljanju priobalnim ribarstvom na osnovu ekoloških principa i očuvanju biološke raznolikosti u Jadranu.]]></summary_hr><summary_en><![CDATA[Unfortunately, many of coastal habitats are under increasing environmental and anthropogenic pressures and there is a lack of data on causal relationships of these pressures on the marine ecosystems. However, establishing causal relationships between a wide range of stressors and effects at the individual, species or community level on marine ecosystems, is a difficult task.Estuaries and coastal areas are commonly acknowledged as highly productive and valuable ecosystems. Their role as nurseries for early life stages of many species has been highlighted. There is ambiguous evidence regarding the importance of habitat characteristics in driving patterns of fish population dynamics. Thus, the main research goals of this project are large-scale assessment of fish nursery grounds along the middle Adriatic coast, spatio-temporal trends in the structure of juvenile fish communities in nurseries with inter-annual variability in juvenile densities and year-class strength for certain economically important species; connectivity between estuarine and coastal habitats: through otolith elemental fingerprints unraveling fish movement and temporal consistence of individual nursery contributions to coastal areas. Also, temporal changes in juvenile fish assemblages structure over two decades with baseline of diversity metrics characterizing the change in taxonomic community composition through time, determining whether there has been an increase in warm-water affinity species and eventual higher incidence of pelagic species will be analyzed attempting to provide evidence for faunal changes. Research in the framework of the proposed project will be conducted along the middle eastern Adriatic coast applying modern fieldwork and analysis methods. The project team will build new research capacities while the results of the project are fully applicable for implementation in the ecology-based management of coastal fisheries and biodiversity conservation in the Adriatic Sea.]]></summary_en></project><project>
<id>7818</id><title_hr><![CDATA[Opterećenja vjetra i mora na energetske konstrukcije]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4960</user_id><user_firstLast_name>Hrvoje Kozmar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-1962</code><acronim><![CDATA[WESLO]]></acronim><duration>01.10.2018 - 31.01.2020</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, </scie_field_hr><scie_field_en>Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>25331</team_members_id><team_members_names><![CDATA[ Doktorand: Danijel Bosnar ]]></team_members_names><keywords_hr><![CDATA[Inženjerstvo vjetra, aerodinamika okoliša, vjetar i konstrukcije, opterećenja mora, vjetroturbina, pučinska konstrukcija, zračni tunel]]></keywords_hr><keywords_en><![CDATA[Wind engineering, environmental aerodynamics, wind and structures, sea loads, wind turbine, offshore structure, wind tunnel]]></keywords_en><summary_hr><![CDATA[Vjetroturbine i pučinske platforme su izložene ekstremnim vremenskim uvjetima uključujući djelovanje vjetra, mora i valova. Da bi se produljio njihov vijek trajanja i povećala učinkovitost nužno je pažljivo analizirati utjecaje opterećenja okoliša na te objekte i predložiti odgovarajuća inženjerska rješenja. Uočeno je da su opterećenja vjetra, valova i mora na pučinske energetske objekte prethodno uglavnom bila analizirana odvojeno. Također se aerodinamička opterećenja na vjetroturbine u blizini brdovite obale i otoka bitno razlikuju od opterećenja na ravnom terenu i otvorenoj pučini, a karakteristike mahovitih vjetrova su u velikoj mjeri nepoznate u inženjerskim krugovima. Uz modelska laboratorijska ispitivanja, važan alat predstavljaju i računalne simulacije, u kojima trenutno nije moguće adekvatno reproducirati karakteristike atmosferske turbulencije. Sukladno navedenom vrlo aktualne istraživačke teme su: a) karakterizacija ekstremnih opterećenja i odziva vjetroturbina i platformi istovremeno uzrokovanih vjetrom, valovima i morskim strujama, b) aerodinamička opterećenja vjetroturbina u blizini brdovitog terena, c) karakteristike turbulencije mahovitog vjetra bure u obliku prikladnom za inženjersko projektiranje konstrukcija, d) metodologija računalne simulacije atmosferskog graničnog sloja i primjena na proračun opterećenja vjetroturbina i platformi. Da bi se navedeni ciljevi u potpunosti ostvarili u radu će biti korištene napredne istraživačke metode uključujući mjerenja u prirodi, laboratorijske eksperimente, računalnu mehaniku i dinamiku fluida. Budući da se integralna opterećenja vjetra, valova i morskih struja na energetske konstrukcije u potpunosti mogu analizirati isključivo kroz suradnju različitih grana znanosti i tehnike, istraživačka grupa u okviru ovog projekta na jedinstveni način uključuje stručnjake iz područja strojarstva, građevine, meteorologije i pomorske tehnike.]]></summary_hr><summary_en><![CDATA[Wind turbines and offshore platforms are exposed to a harsh marine environment including wind, wave and sea current loads. To extend their lifetime and increase energy production, it is necessary to carefully analyze effects of environmental loads on those structures and suggest appropriate engineering solutions. In the past, wind, wave and sea loads on offshore energy structures were commonly studied separately. In addition, aerodynamic loads on wind turbines close to hilly coast and islands are considerably different than the loads on wind turbines in flat terrain and open sea, whereas transient wind characteristics are fairly unknown to engineers. In addition to laboratory experiments, computational simulations are valuable tools to determine wind and sea loads on wind turbines and platforms. An important drawback with this approach at the moment is that it is not possible to completely accurately simulate characteristics of atmospheric turbulence. Hence, very contemporary research topics are: a) characterization of extreme loads and response of wind turbines and platforms simultaneously induced by wind, waves and sea currents, b) aerodynamic loads on wind turbines in complex terrain, c) characteristics of bora wind turbulence in a form usable for engineering design of structures, d) computational simulation methodology for the atmospheric boundary layer and application on wind-turbine and platform loads. To achieve those goals, various advanced research tools will be used including field measurements, small-scale laboratory experiments, computational mechanics and fluid dynamics. As integral wind, wave and sea current loads on energy structures can be completely analyzed only in case different engineering/science disciplines are involved, the research group on this project uniquely includes experts from mechanical and civil engineering, meteorology and offshore engineering in a unique blend of disciplines.]]></summary_en></project><project>
<id>7820</id><title_hr><![CDATA[BILJKE KAO IZVOR BIOAKTIVNIH SUMPOROVIH SPOJEVA TE NJIHOVA SPOSOBNOST HIPERAKUMULACIJE METALA]]></title_hr><title_en><![CDATA[]]></title_en><user_id>403</user_id><user_firstLast_name>Tea  Bilušić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-9627</code><acronim><![CDATA[BioSMe]]></acronim><duration>01.09.2018 - 30.11.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Prehrambena tehnologija, </scie_field_hr><scie_field_en>Food technology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Kemijsko-tehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Chemistry and Technology]]></institution_en><team_members_id>25207</team_members_id><team_members_names><![CDATA[ Doktorand: Ivana Vrca ]]></team_members_names><keywords_hr><![CDATA[bioaktivni sumporovi spojevi, antioksidacijsko djelovanje, antitumorsko djelovanje, antimikrobno djelovanje, hiperakumulacija metala]]></keywords_hr><keywords_en><![CDATA[bioactive sulphur compounds, antioxidative activity, anticancer activity, antimicrobial activity, metal hyperaccumulation]]></keywords_en><summary_hr><![CDATA[Gotovo četvrtina svih farmaceutskih proizvoda u svijetu se dobiva iz biljaka. Biljni metaboliti sa sumporom uključuju raznolike kemijske strukture koji upravo zbog prisutnosti sumpora pokazuju određene fizikalno-kemijske značajke i međudjelovanja s različitim molekulskim i biološkim metama.Botanički red Brassicales, u koji ubrajamo brojne svakodnevno korištene vrste povrća (kupus, brokula, kapare itd.), je izrazito kemokarakteriziran prisutnošću tiosaharidnih sekundarnih metabolita-glukozinolata (GLa). GLi su spojevi koji se neprekidno istražuju, otkrivaju se i nove strukture pa danas ta grupa fitokemikalija broji oko 130 spojeva. Projekt će se usredotočiti na slabo ili prethodno neistražene samonikle vrste (endemske i dr.) iz reda Brassicales. GLi, koji su povezani s atipičnom endogenom glukohidrolazom-mirozinazom (E.C.3.2.1.147), djeluju kao bioprekursori biološki aktivnim izotiocijanatima te im je, u posljednjih 20 godina, posvećena posebna pozornost zbog korisnih učinaka na zdravlje. Specifični ciljevi ovog projekta uključuju njihovu izolaciju i biološka ispitivanja. Korisni biološki učinci biljaka koje sadrže sumporove derivate očituju se njihovom svakodnevnom upotrebom u prehrani. Kako bi spoj pokazao aktivnost in vivo, mora biti stabilan i biodostupan te će se isti istražiti u uvjetima simuliranog dvofaznog probavnog procesa korištenjem ljudskih probavnih enzima (želučani i crijevni). Istraživanje novih GLa i drugih biljaka koje sadrže biološki aktivne sumporove spojeve može potaknuti razvoj novih hortikulturalnih usjeva. Do danas je poznat veliki broj biljnih vrsta iz porodice Brassicaceae koje posjeduju sposobnost hiperakumulacije metala. Mnogi metali, ne samo da se hiperakumuliraju, već spadaju u esencijalne nutrijente pa se obogaćivanje hrane mikronutrijentima i fitoremedijacija mogu promatrati kao dvije strane istog novčića. Određivanje sposobnosti akumuliranja metala predstavlja jedan od bitnih aspekata uporabe ovih biljaka.]]></summary_hr><summary_en><![CDATA[Nearly quarter of all pharmaceutical products worldwide are derived from plant sources. Sulphur-containing plant metabolites include a variety of chemical structures which due to the presence of sulphur show particular physicochemical features and interact with a range of molecular and biological targets.The botanical order of the Brassicales-which encompasses many of our daily vegetables (cabbage, broccoli, capper etc.) is strikingly chemocharacterized by the presence of thiosaccharidic secondary metabolites-glucosinolates (GLs). GL investigation is an ongoing research activity and new structures have been documented, now including ca. 130 compounds. This project will focus on scarcely or previously not investigated wild-growing species (endemic and other) from the botanical order Brassicales.Associated with an uncommon endogenous glucohydrolase-myrosinase (E.C.3.2.1.147) GLs operate like precursors to biologically active isothiocyanates. Over the last 20 years these compounds have gained growing attention owing to their health-promoting properties. Specific focus of the project will involve their isolation and biological testing.The beneficial effects have been attributed to dietary consumption of sulphur containing vegetables. In order for any compound to exert an activity in vivo it is necessary to show stability and bioaccessibility. Thus they will be investigated under conditions of simulated two-step digestion process using human digestive enzymes (gastric and duodenal). Investigating novel GLs and other biologicaly active sulphur-containing plants may stimulate the development of new horticultural crops.As on to date many plants of Brassicaceae family are known to hyperaccumulate metals. As many of the metals that can be hyperaccumulated are also essential nutrients, food fortification and phytoremediation might be considered two sides of the same coin. Thus, analyzing plant capacity to accumulate metals represents one of the crucial aspects of plant usage.]]></summary_en></project><project>
<id>7821</id><title_hr><![CDATA[Enhancing Coastal Management in the Adriatic and the Black Sea by Using Nuclear Analytical Techniques]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3983</user_id><user_firstLast_name>Jasmina Obhođaš</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-8678</code><acronim><![CDATA[]]></acronim><duration>04.09.2018 - 01.01.2023</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Interdisciplinarne prirodne znanosti, </scie_field_hr><scie_field_en>Interdisciplinary natural sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>25277</team_members_id><team_members_names><![CDATA[ Doktorand: Andrija Vinković ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>7824</id><title_hr><![CDATA[Višekomponentne reakcije u sintezi peptidnih mimetika]]></title_hr><title_en><![CDATA[]]></title_en><user_id>558</user_id><user_firstLast_name>Matija Gredičak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-8487</code><acronim><![CDATA[MIMICRy]]></acronim><duration>02.10.2018 - 01.10.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>25282</team_members_id><team_members_names><![CDATA[ Doktorand: Mateja Matišić ]]></team_members_names><keywords_hr><![CDATA[peptidomimetici, višekomponentne reakcije, makrociklički spojevi, neprirodne aminokiseline, ugljikohidrati, endiinski spojevi]]></keywords_hr><keywords_en><![CDATA[peptidomimetics, multicomponent reactions, macrocycles, non-natural amino acids, carbohydrates, enediyne compounds]]></keywords_en><summary_hr><![CDATA[Probir biblioteka malih molekula je najčešće korišten pristup u otkriću novih lijekova u posljednih dvadeset godina. Međutim, glavni nedostatak biblioteka je mala raznovrsnost bioloških i kemijskih svojstva spojeva koje sadrže, tj. biblioteke pokrivaju vrlo mali «kemijski prostor». U posljednjih 15 godina, svega 15 % novih kemijskih spojeva zapravo pripadaju novim klasama spojeva. To predstavlja glavnu zapreku razvoju novih vodećih spojeva potrebnih za istraživanje novih bioloških meta. Cilj ovog projekta je proširiti kemijski prostor novim spojevima koji imaju slične karakteristike kao i prirodni spojevi, korištenjem višekomponentnih reakcija. To ćemo postići: (a) razvojem novih gradivnih jedinica temeljenih na neprirodnim aminokiselinama, ugljikohidratima i endiinskim spojevima, (b) provođenjem Passerinijeve i Ugijeve reakcije za dobivanje raznovrsnih linearnih i cikličkih produkata i (c) proučavanjem stereokemije višekomponentnih reakcija.  	Rezultati projekta i znanje o metodologiji, stereokemiji i svojstvima novih spojeva značajni su za istraživanja u više područja: medicinska kemija (nove strukture za obogaćivanje biblioteka spojeva), razvoj katalizatora (posebno makrociklički spojevi s endiinskom jedinicoma) i biomedicinska istraživanja (spojevi s ugljikohidratnim strukturnim elementom mogu se koristiti kao biološke probe). Projekt je usklađen s ciljevima Hrvatske zaklade za znanost: razvoj konkurentnog istraživačkog okruženja i stvaranje novih znanja za jačanje hrvatskog gospodarstva. Rezultati projekta će biti temelj za stvaranje bibliteka sa strukturno različitim malim molekulama i makrocikličkim spojevima, kao odgovor na potrebe farmaceutske industrije: identifikacija još nepoznatih bioloških ciljeva i razvoj novih vodećih spojeva. Stoga projekt doprinosi i jednom od ključnih ciljeva u Europskoj uniji: poboljšanju zdravlja građana EU-a za povećanje bogatstva i dobrobiti ljudi. ]]></summary_hr><summary_en><![CDATA[Screening of small-molecule libraries has been the most commonly used tool in drug discovery over the past two decades. However, currently used libraries lack diversity in terms of biological and chemical properties, i.e. “chemical space” covered is infinitely small. In the past 15 years, only 15 % of the emerging novel chemical entities have been novel classes of compounds. This limitation significantly hampers development of novel lead compounds needed to tackle new generations of biological targets. The project goal is to expand the chemical space of natural product-like compounds by using multicomponent reactions. This will be achieved by: (a) developing novel non-natural amino acid-, carbohydrate- and enediyne-based building blocks; (b) performing Passerini and Ugi multicomponent reactions to obtain structurally diverse linear and macrocyclic compounds and (c) studying the stereochemistry of multicomponent reactions. Project results, and the knowledge about methodologies, stereochemistry and properties of novel compounds, are highly relevant for the following fields: medicinal chemistry - novel structures to fill the libraries; catalyst development – particularly enediyne-based macrocycles; and biomedical studies – carbohydrate-based compounds can be used as biological probes. Project is aligned with the goals of the Croatian Science Foundation: development of competitive research environment, and creation of new knowledge for the strengthening the Croatian economy. Project results will be the base for the generation of libraries with structurally diverse peptide-like small molecules and macrocyclic compounds, as an answer to the pharmaceutical industry needs: identification of yet undisclosed biological targets and the development of novel lead compounds. Therefore, project contributes to one the key objectives in the European Union: improving the health of EU citizens for generation of wealth and public wellbeing. ]]></summary_en></project><project>
<id>7826</id><title_hr><![CDATA[Multi stakeholder and governance approach for SECAP development and implementation (PentaHelix)]]></title_hr><title_en><![CDATA[]]></title_en><user_id>13333</user_id><user_firstLast_name>Goran Krajačić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-5323</code><acronim><![CDATA[]]></acronim><duration>01.09.2018 - 01.12.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, </scie_field_hr><scie_field_en>Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>25248</team_members_id><team_members_names><![CDATA[ Doktorand: Marko Mimica ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>7828</id><title_hr><![CDATA[Primjena NGS metoda u procjeni genomske varijabilnosti preživača]]></title_hr><title_en><![CDATA[ Application of NGS in assessment of genomic variability in ruminants]]></title_en><user_id>7343</user_id><user_firstLast_name>Vlatka Čubrić Čurik</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-8708</code><acronim><![CDATA[ANAGRAMS]]></acronim><duration>01.12.2018 - 30.05.2023</duration><status>Završio</status><financ_value>132.258,28 eur</financ_value><scie_area_hr>Prirodne znanosti, Biotehničke znanosti, Tehničke znanosti, Humanističke znanosti, Interdiciplinarne znanosti, </scie_area_hr><scie_area_en>Natural sciences, Biotechnical sciences, Technological sciences, Humanities, Interdisciplinary scientific area, </scie_area_en><scie_field_hr>Interdisciplinarne prirodne znanosti, Biologija, Računarstvo, Poljoprivreda, Arheologija, Interdisciplinarne biotehničke znanosti, </scie_field_hr><scie_field_en>Interdisciplinary natural sciences, Biology, Computer sciences, Agriculture, Archeology, Interdisciplinary biotechnical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Agronomski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Agriculture]]></institution_en><team_members_id>19007, 6650, 6279, 1339, 24095, 4140, 7242, 23715, 7067, 22742, 2738, 7061, 865128, </team_members_id><team_members_names><![CDATA[Vladimir Brajković, Ino Čurik, Maja Ferenčaković, Dinko Novosel, Dinko Radić, Strahil Ristov, Dragica Šalamon, Bruna Tariba, Ivana Držaić, Nikolina Kelava Ugarković, Boris Lukić, Stašo  Forenbaher, Mario Shihabi, ]]></team_members_names><keywords_hr><![CDATA[arheogenetika, konzervacijska genetika, bioraznolikost, genomika, domaće životinje]]></keywords_hr><keywords_en><![CDATA[archaeogenetics, conservation genetics, biodiversity, genomics, livestock]]></keywords_en><summary_hr><![CDATA[Izuzetno brz razvoj metode slijedeće-generacije sekvenciranja (NGS) i računalnih kapaciteta otvorili su nove mogućnosti u različitim znanstvenim područjima (humanoj i veterinarskoj medicini, poljoprivredi, šumarstvu, ekologiji, računalnoj znanosti, pa čak i arheologiji). Uspješna primjena NGS-a i njegova upotreba u različitim discplinama snažno ovisi o stručnosti na nekoliko područja. Ovdje smo okupili stručnjake iz molekularne genetike, populacijske genomike, uzgoja životinja, računalnih znanosti i arheologije kako bismo odgovorili na nekoliko tema vezanih uz konzervacijsku genomiku (efektivnu veličinu populacije, inbreeding i štetno opterećenje genoma) i genomsku biološku raznolikost (izmješanost i poulacijska struktura) preživača. Također ćemo analizirati drevne kosti (>3000 godina) goveđih, kozjih i ovčjih jedinki kako bismo poboljšali naše razumijevanje genomskih promjena u postupku domestikacije (filogeneza mitogenoma). Naš projektni prijedlog ima snažnu komponentu teorijskih dostignuća za procjenu inbreedinga, efektivne veličine populacije i pojedinačnog umješavanja analiziranih računalnim simulacijama (sve oponašaju sekvence). Osim toga, NGS analiza (visoko propusni SNP beadchip i sekvence cijelkupnog genoma) izvoditi će se na nekoliko autohtonih pasmina (goveda, koza i ovaca) sa slijedećim ciljevima; (i) osigurati “genomsko pozicioniranje” hrvatskih pasmina među ostalim svjetskim pasminama, (ii) pružiti procjenu statusa konzervacije hrvatskih pasmina (razina inbreedinga, veličinu efektivne populacije, štetno opterećenje i genetsku raznolikost) i (iii) identificirati genomsku jedinstvenost (genomske regije) koje su specifične za hrvatske autohtone pasmine. Dobiveni rezultati pružit će temelj za buduće upravljanje očuvanjem pasmina. Primjena NGS-a ima snažan potencijalni ekonomski učinak na društvo u budućnosti. Zbog toga ćemo organizrati otvoreni tečaj “Genomika za zaštitu životinja”, napisat nekoliko popularizirajućih članaka i educirati doktorande.]]></summary_hr><summary_en><![CDATA[The extremely fast developments of next-generation-sequencing (NGS) and computer capacity have opened a large number of new possibilities in diverse scientific areas (human and veterinary medicine, agriculture, forestry, ecology, computer science and even archaeology). Unfortunately, successful application of NGS and its application in diverse disciplines is strongly depended on the expertise in several fields. Here we gathered experts from molecular genetics, population genomics, animal breeding, computer science and archaeology to address several topics related to conservation genomics (effective population size, inbreeding and detrimental load) and genomic biodiversity (admixture and population structure) of ruminants. We will also analyse ancient bones (>3000 years) belonging to bovine, caprine and ovine individuals in order to improve our understanding of genomic changes in the domestication process (mitogenome phylogenetics). Our proposal has strong component of theoretical developments for estimation of inbreeding, effective population size and individual admixture analysed by computer simulations (all imitating sequence data). In addition, NGS analyses (high-throughput SNP beadchip and whole genome sequencing) will be performed on several autochthonous breeds (cattle, goat and sheep) with following aims; (i) to provide &#39;&#39;genomic positioning&#39;&#39; of Croatian breeds among other world breeds, (ii) to provide estimates of the conservation status of Croatian (inbreeding level, effective population size, admixture, detrimental load, genetic diversity) and (iii) to identify genomic uniqueness (genomic regions) that are specific for Croatian autochthonous breeds. Results obtained will provide basis for their future conservation management. Application of NGS has strong potential economic impact on the society in future. For that reason, we will organise open course &#39;&#39;Livestock Conservation Genomics&#39;&#39;, write several popularisation articles and train two PhD students.]]></summary_en></project><project>
<id>7831</id><title_hr><![CDATA[Intenzifikacija fotokatalitičkih i katalitičkih procesa za obradu otpadnih voda i otpadnih plinova]]></title_hr><title_en><![CDATA[Intensification of photocatalytic and catalytic processes for wastewater and waste gases treatment ]]></title_en><user_id>3295</user_id><user_firstLast_name>Vesna  Tomašić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-8669</code><acronim><![CDATA[IN-PhotoCat]]></acronim><duration>01.11.2018 - 31.10.2022</duration><status>Završio</status><financ_value>121.242,29 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Kemijsko inženjerstvo, Temeljne tehničke znanosti, </scie_field_hr><scie_field_en>Chemical engineering, Basic engineering sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet kemijskog inženjerstva i tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Chemical Engineering and Technology]]></institution_en><team_members_id>24210, 3943, 6813, 24022, 25646, 855353, 17771, 855436, </team_members_id><team_members_names><![CDATA[Zoran Gomzi, Vanja Kosar, Marina Duplančić, Jerome Le Cunff, Filip Car, Ivana Elizabeta Zelić, Vanja Gilja, Vjeran Gomzi, ]]></team_members_names><keywords_hr><![CDATA[intenzifikacija procesa, heterogena fotokataliza, monolitni reraktori, neonikotinoidni insekticidi, aromatski hlapljivi organski spojevi]]></keywords_hr><keywords_en><![CDATA[process intensification, heterogeneous photocatalysis, monolithic reactors, neonicotinoidic insecticides, aromatic volatile compounds]]></keywords_en><summary_hr><![CDATA[Znanstvenici i inženjeri na uglednim sveučilištima i industrijskim istraživačkim centrima intenzivno rade na otkriću novih procesnih uređaja i tehnika, koji će predstavljati velik iskorak u odnosu na dosadašnja saznanja o kemijskim procesnim postrojenjima i omogućiti razvoj integriranih, sigurnijih, energetski učinovitijih i ekološki prihvatljivijih tehnologija. Zahvaljujući snažnom razvoju znanosti i sve većem interesu javnosti za ovo područje, intenzifikacija procesa postepeno se počinje izdvajati kao nova disciplina unutar kemijskog inženjerstva. Cilj predloženog projekta je razvoj novih fotokatalizatora i katalizatora te inovativnih izvedbi fotokatalitičkih i katalitičkih reaktora primjenom temeljne metodologije kemijskog inženjerstva i osnovnih načela intenzifikacije procesa s ciljem njihove primjene za rješavanje globalnih problema vezanih uz obradu otpadnih voda i otpadnih plinova te izrade odgovarajućih prototipova reaktora. Aktivnosti na projektu obuhvaćat će dva katalitička sustava: fotokatalitičku razgradnju neonikotinoidnih insekticida na novim fotokatalizatorima s povećanom aktivnošću u vidljivom dijelu sunčevog spektra i heterogenu katalitičku oksidaciju smjese aromatskih hlapljivih organskih spojeva (BTEX) u plinskoj fazi u keramičkim monolitnim reaktorima. Izvornost i značaj predloženog projekta za hrvatsku javnost i njezinu promociju u svijetu očituje se u razvoju inovativnih tehnologija zaštite okoliša s visokim potencijalom za transfer takvih tehnologija u realne sustave te u usmjerenosti predloženog projekta na stjecanje novih znanja, vještina i osposobljavanje mladih istraživača. Rezultati projekta bit će prezentirani na domaćim i međunarodnim znanstvenim skupovima što će hrvatskim znanstvenicima osigurati veću vidljivost i omogućiti sudjelovanje na kompetitivnim međunarodnim projektima iz navedenog područja.]]></summary_hr><summary_en><![CDATA[Scientists and engineers at renowned universities and industrial research centers are working intensively on the discovery of new process equipment and techniques, which will represent a major breakthrough in relation to existing knowledge of chemical process facilities and enable the development of integrated, safer, more energy-efficient and environmentally-friendly technologies. Thanks to the strong development of science and the growing interest of the public in this area, the process intensification gradually begins to emerge as a new discipline within chemical engineering. The aim of the proposed project is the development of new photocatalysts and catalysts as well as innovative performance of photocatalytic and catalytic reactors using the basic methodology of chemical engineering and basic principles of process intensification. The goal is in their potential application to solve global problems related to the wastewater and waste gases treatment and design of appropriate prototypes of reactors. Project activities will include two catalytic systems: photocatalytic degradation of neonicotinoid insecticides on new photocatalysts with increased activity in the visible part of the solar spectrum and heterogeneous catalytic oxidation of the mixture of aromatic organic compounds (BTEX) in the gas phase in various designs of ceramic monolithic reactors. The originality and significance of the proposed project for the Croatian public and its promotion in the world is reflected in the development of innovative environmental technologies with high potential for technology transfer to the realistic systems as well as in focusing of the proposed project to acquire new knowledge, skills and training of young researchers. The results of the project will be presented at national and international scientific conferences, which will enable Croatian scientists to gain greater visibility and enable participation in competitive international projects from the mentioned area.]]></summary_en></project><project>
<id>7833</id><title_hr><![CDATA[Optomehanika uzrokovana frekventnim češljem]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5410</user_id><user_firstLast_name>Ticijana Ban</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-7489</code><acronim><![CDATA[MeCombO]]></acronim><duration>20.09.2018 - 19.12.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut za fiziku]]></institution_hr><institution_en><![CDATA[Institute of Physics in Zagreb]]></institution_en><team_members_id>25234</team_members_id><team_members_names><![CDATA[ Doktorand: Mateo Kruljac ]]></team_members_names><keywords_hr><![CDATA[optomehanika, frekventni češalj, optička šupljina, spektroskopija, koherencija, hladni atomi, rubidij, magneto-optička zamka (MOT), dipolna zamka]]></keywords_hr><keywords_en><![CDATA[optomechanics, frequency comb, optical cavity, spectroscopy, coherence, cold atoms,rubidium, magneto-optical trap (MOT), optical dipole trap]]></keywords_en><summary_hr><![CDATA[Sila na atome uzrokovana kontinuiranim (eng. continuous wave, cw) laserima predstavlja centralni dio istraživanja u području atomske fizike već zadnjih nekoliko desetljeća. Radijativna sila čini osnovu za lasersko hlađenje i zarobljavanje atoma, čime je omogućeno stvaranje dovoljno gustih i hladnih atomskih uzoraka. Ipak, unatoč opsežnom i dobro shvaćenom području optomehanike uzrokovane cw laserom, istraživanja sila na atome uslijed interakcije s nizom ultrakratkih pulseva (odnosno frekventnim češljem) su oskudna. U međuvremenu, rezultati istraživanja provedenih u našoj grupi ukazuju na to da se, u specifičnoj geometriji pobude atoma frekventnim češljem, javljaju posve novi fenomeni koji zahtjevaju dodatna eksperimentalna i teorijska istraživanja.  Cilj ovog projekta je istraživanje novih fenomena koji se javljaju uslijed dijelovanja sile na atome uzrokovane frekventnim češljem (FC), a uključuje fenomene sprezanja i dekoherencije, stvaranja dipolne zamke s fs laserima u blizini atomske rezonancije te hlađenje atoma u optičkoj šupljini (rezonatoru) uzrokovano FC-om. Predložena istraživanja otvorit će nekoliko intrigantnih tema u području istraživanja koje je relevantno znanstvenoj zajednici širom svijeta. Predloženi će projekt utjecati na podizanje prepoznatljivosti hrvatske znanosti u svijetu, zapošljavanje i usavršavanje mladih istraživača i jačanje kapaciteta Instituta za fiziku putem međunarodne suradnje.]]></summary_hr><summary_en><![CDATA[Inducing mechanical action on atoms by continuous wave (cw) laser excitation has been a central topic in atomic physics for decades. Yet, in contrast to the rich and fruitful field of cw-laser-induced optomechanics, the investigations of mechanical action on atoms due to interaction with trains of ultrashort laser pulses (i.e. frequency combs) are scarce in literature. Meanwhile, recent results made in our group have indicated that in a specific excitation geometry an entirely new type of FC-atom interaction emerges that calls out for further experimental and theoretical investigation.The aim of the project is to explore novel phenomena that arise when the mechanical action on cold atoms is induced by frequency comb (FC) excitation, including entanglement and decoherence, near-resonance dipole trap, and frequency-comb-induced cavity cooling. The proposed research will open up several intriguing topics in the field of research that is relevant to the scientific community worldwide.The proposed project will increase the visibility of Croatian science, employ and educate young researchers and strengthen the capacity of the Institute of Physics through international cooperation.]]></summary_en></project><project>
<id>7835</id><title_hr><![CDATA[Protein carbonylation in healthy ageing and age-related disease – CarboNyx ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5769</user_id><user_firstLast_name>Janoš Terzić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-7406</code><acronim><![CDATA[]]></acronim><duration>01.07.2018 - 09.09.2024</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Javno zdravstvo i zdravstvena zaštita, </scie_field_hr><scie_field_en>Public health and health services, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Split School of Medicine]]></institution_en><team_members_id>19117</team_members_id><team_members_names><![CDATA[ Doktorand: Ajka Relja ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>7837</id><title_hr><![CDATA[Hrvatska longitudinalna studija tjelesne aktivnosti u adolescenciji]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1126</user_id><user_firstLast_name>Maroje Sorić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-2328</code><acronim><![CDATA[CRO-PALS]]></acronim><duration>01.09.2018 - 30.09.2021</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Javno zdravstvo i zdravstvena zaštita, </scie_field_hr><scie_field_en>Public health and health services, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Kineziološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Kinesiology]]></institution_en><team_members_id>25220</team_members_id><team_members_names><![CDATA[ Doktorand: Josip Karuc ]]></team_members_names><keywords_hr><![CDATA[tjelesna neaktivnost, zdravlje, pretilost, sedntarna ponašanja, mladež]]></keywords_hr><keywords_en><![CDATA[inactivity, health, obesity, sedentarism, youth]]></keywords_en><summary_hr><![CDATA[Nedovoljna tjelesna aktivnost (TA) na četvrtom je mjestuvodećih rizika smrtnosti u svijetu. Tijekom adolescencijesmanjuje se u oba spola, a determinante i ishodi tog smanjenjanisu u potpunosti razjašnjeni. Stoga su ciljevi ovog istraživanja:analizirati obrasce promjena TA tijekom adolescencije; identificirati determinante TA i sedentarnih ponašanja tijekom ovog razdoblja; istražiti povezanost TA i sedentarnih ponašanja sa nekim sa zdravljem povezanim ishodima; identificirati moderatore tih povezanosti. Ovaj projekt se naslanja na tekuće longitudinalno istraživanje koje je započelo 2014. godine, a obuhvaća  903 učenika iz 14 slučajno odabranih zagrebačkih srednjih škola. TA i sedentarna ponašanja se procijenjuju SHAPES upitnikom i pomoću multisenzornog monitora TA (the SenseWear Armband).Za evaluaciju motivacije koristit se &#39;The Motives for Physical Activity Measure- Revised&#39; upitnik. Trajanje spavanja ispituje se SWA monitorom i upitnikom. Dijetetske metode uključuju 24-h prisjećanje unosa hrane i upitnik o učestalosti unosa hrane. BMI, WHR i % tjelesne masti računaju se temeljem antropometrije.Krvni tlak mjeri se u skladu s ESH preporukama, a pušenje i socio-ekonomski faktori procijenjuju se upitnicima. Subjektivni osjećaj zdravlja ispituje se hrvatskom verzijom upitnika KIDSCREEN-27, a koncept mentalnog zdravlja primjenom &#39;&#39;TheStrengths and Difficulties Questionnaire&#39;&#39;. Mjeru školskog uspjeha čini prosjek ocjena na kraju školske godine. Obrada podataka temeljit će se većinom na višerazinskom modeliranju za ponavljana mjerenja. Rezultati ovog projekta omogućit će bolje razumijevanje determinanti i moderatora TA i sedentarnih ponašanja u mladih. Nadalje, rasvijetlit će se relativna uloga TA i sedentarnih ponašanja u povezanostima sa zdravstvenim ishodima, što će doprinijeti i znanstveno utemeljenom planiranju ciljanih intervencijskih programa primarne prevencije kroničnih bolesti.]]></summary_hr><summary_en><![CDATA[Lack of physical (PA) is recognized as the fourth leading risk for global death. During adolescence PA declines in both genders. Still, determinants and outcomes of this decline remain to be clarified. The aims of this study are: to analyze patterns ofchange in PA during adolescence; to identify determinants and moderators of PA and sedentary behaviours in this period; to explore the effect of PA and sedentary behaviours on several health related outcomes; to examine how different correlates of PA moderate the effect of PA and sedentary behaviours on health-related outcomes. The project extends on the on-going prospective longitudinal study that started in 2014 and involves around 900 high school students from the city of Zagreb (Croatia). PA and sedentary behaviours are assessed annually during 4 years of high school education by the SHAPES questionnaire and by the SenseWear Armband multiple-sensor activity monitor. Motivation for PA is evaluated by &#39;The Motives for Physical Activity Measure - Revised&#39; and perceived health by the KIDSCREEN-27 questionnaire. Sleep is examined using several self-report instruments and by the SWA monitor. The 24-h dietary recall and a food frequency questionnaire are applied. BMI, WHR and body fat percentage will be calculated based on anthropometry. Blood pressure is  taken following ESH guidelines. Smoking and socioeconomic factors will be assessed through questionnaires. Mental health is evaluated by the Strengths and Difficulties Questionnaire; grade point average will be used as a measure of academic achievement. Data analytic techniques will mostly rely on multi-level modelling for repeated measures. The results of this study will aid in understanding PA decline in youth, its determinants and moderators. In addition, the relative importance of PA and sedentary behaviours for physical and mental health will be elucidated. Consequently, future interventions aimed at primary prevention of chronic diseases will be improved.]]></summary_en></project><project>
<id>7838</id><title_hr><![CDATA[Značaj interakcija metalnih nanočestica sa sumpornim biomolekulama za nano-bio sučelje ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>573</user_id><user_firstLast_name>Ivana Vinković Vrček</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-8860</code><acronim><![CDATA[NanoFaceS]]></acronim><duration>01.07.2018 - 30.06.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut za medicinska istraživanja i medicinu rada]]></institution_hr><institution_en><![CDATA[Institute for Medical Research and Occupational Health]]></institution_en><team_members_id>25203</team_members_id><team_members_names><![CDATA[ Doktorand: Rinea Barbir ]]></team_members_names><keywords_hr><![CDATA[metalne nanočestice, sumporne biomolekule, nanomedicina, interakcije, vezanje]]></keywords_hr><keywords_en><![CDATA[metallic nanoparticle, sulphur containing biomolecules, nanomedicine, interactions, binding]]></keywords_en><summary_hr><![CDATA[Nanomedicina kao područje primjene nanotehnologije u razvoju zaštite zdravlja ima veliki utjecaj na razvoj inovativnih medicinskih tretmana i terapija. Primjena nanočestica (NP) ima ogroman potencijal za učinkovitiju isporuku lijekova i gena, u razvoju fluorescentnih i kontrastnih dijagnostičkih alatki u medicini. ...Međutim, opsežna in vivo primjena NP zahtijeva iscrpnije istraživanje fizikalno-kemijskih i fizioloških procesa koji se odvijaju u biološkim uvjetima. Takvo &#39;nano-bio&#39; sučelje obuhvaća dinamičke fizikalno-kemijske interakcije, te kinetiku i termodinamiku razmjene između površine nanočestica i bioloških površina. ...Nemoguće je potpuno opisati sve čimbenike značajne za to sučelje, ali su za daljnji razvoj nanomedicine nužne dodatne informacije o specifičnim interakcijama nanočestica s bioaktivnim komponentama prisutnim u živim stanicama i tkivima. Glavni cilj predloženog NanoFaceS projekta je pružiti nove  informacije o prirodi &#39;&#39;nano-bio &#39;sučelja između metalnih teranostičkih nanomaterijala i biomolekula koje sadrže sumpor (S-biomolekula), a koje imaju važnu i  kompleksnu funkcionalnu ulogu u živim sustavima. ...Modelni sustav NanoFaceS projekta čini (i) skup nanočestica s jezgrom od srebra, zlata i željezovog oksida,  različitih fizikalno kemijskih svojstava (veličine, površinskog naboja i kemijskog sastava) i (ii)  šest važnih S-biomolekula: cistein, glutation, metalotionein, albumin i inzulin. ... Konceptualni temelj predloženog projekta jest multimetodološki i multidisciplinarni pristup koji će pružiti nove uvide u prirodu specifičnih bioloških interakcija NP sa S-biomolekulama. Projekt će na taj način značajno doprinijeti znanju potrebnom za daljnji razvoj nanomedicinskog područja..........]]></summary_hr><summary_en><![CDATA[Nanomedicine, the application of nanotechnology to healthcare, has great impact on innovation of medical treatments and therapies. Nanoparticles (NPs) have an enormous potential in the medical arena as drug and gene delivery vehicles, fluorescent labels and contrast agents. ...However, extensive in vivo applications of NPs require a more exhaustive exploration of the physicochemical and physiological processes coupled with introduction of NPs to biological environments. The dynamic physicochemical interactions, kinetics and thermodynamic exchanges between NPs surfaces and the surfaces of biological components give rise to the ‘nano–bio’ interface. It is impossible to inevitably describe all events at this interface, but additional information on the more specific interplay of NPs with bioactive components of living cells and tissues are of the highest relevance for prospective evolution of nanomedicine....Proposed NanoFaceS project aims to provide a body of new information and new knowledge to the nanomedical endeavor in addressing the scientific uncertainties related to the beyond-state-of-the-art interaction of engineered metal-based NPs, used in theranostics, and sulfur-containing biomolecules (S-biomols), important in living systems due to their complex functional roles. NanoFaceS will use model system comprising (i) a set of silver, gold and iron oxide NPs with varying physico-chemical properties, i.e. size, surface charge and chemical composition and (ii) six representative S-biomols: cysteine, glutathione, metallothionein, albumin and insulin. ...The underlying concept of NanoFaceS will be based on understanding of interactions between NPs and S-biomols by implementing multimethodological and multidisciplinary approach which would yield competence on biological consequences of NPs interaction with S-biomols. As a major outcome, project will provide substantial knowledge to the nanomedical landscape....]]></summary_en></project><project>
<id>7840</id><title_hr><![CDATA[Istraživanje ekološki osjetljivih područja komercijalno značajnih morskih organizama s naglaskom na rast i razvoj i zaštitu najmlađih razvojnih stadija]]></title_hr><title_en><![CDATA[Exploration of ecologically sensitive areas with special emphasis on growth, development and protection of commercially important maritime organisms]]></title_en><user_id>669</user_id><user_firstLast_name>Barbara Zorica</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-8013</code><acronim><![CDATA[ESAmar]]></acronim><duration>27.09.2018 - 26.09.2022</duration><status>Završio</status><financ_value>108.950,06 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Interdisciplinarne biotehničke znanosti, Biotehnologija, </scie_field_hr><scie_field_en>Interdisciplinary biotechnical sciences, Biotechnology, </scie_field_en><institution_hr><![CDATA[Institut za oceanografiju i ribarstvo]]></institution_hr><institution_en><![CDATA[Institute of Oceanography and Fisheries]]></institution_en><team_members_id>668, 7025, 13709, 1029, 29300, </team_members_id><team_members_names><![CDATA[Vanja Čikeš Keč, Nedo Vrgoč, Igor Isajlović, Ivana Lepen Pleić, Lana Schmidt, ]]></team_members_names><keywords_hr><![CDATA[mrijestilišta, rastilišta, demerzalne vrste, pelagične vrste, DNA analiza]]></keywords_hr><keywords_en><![CDATA[spawning habitat, nursery habitat, demersal species, pelagic species, DNA analysis]]></keywords_en><summary_hr><![CDATA[Biološka obnovljiva bogatstva Jadrana čine brojne pridnene i pelagične vrste riba, rakova i glavonožaca. Dugoročno održivo stanje populacija ovisno je, kako o intenzitetu eksploatacije, tako i o intenzitetu novačenja svake vrste. Na sam uspjeh novačenja utječe čitav niz abiotičkih i biotičkih čimbenika koji karakteriziraju ekološki osjetljiva staništa, kao i kasnije migracije u šira područja rasprostranjenja. Kako bi se osiguralo dugoročno održivo ribarstvo kao nužno se nameće uspostavljanje adekvatnih mjera zaštite ekološki osjetljivih područja kao i definiranje stanja populacija i zajednica koje ih nastanjuju s naglaskom na komercijalno najznačajnije vrste.  Glavni cilj predloženog Projekta je identifikacija ekološki osjetljivih staništa komercijalno važnih pridnenih i pelagičnih vrsta u Jadranu, opisivanje stanja populacija i zajednica u njima, kao i definiranje osnovnih ekoloških parametara ključnih za njihov uspješni rast i razvoj. Specifični ciljevi istraživanja su: 1) kritički pregled i analiza postojećih podataka o mrijestilištima, rastilištima i razmnožavanju komercijalno važnih organizama u Jadranskom moru; 2) identifikacija ekološko osjetljivih područja (mrijestilišta i rastilišta) razmatranih vrsta; 3) prikupljanje podataka o rasprostranjenosti, dinamici populacija i indeksima gustoće različitih razvojnih faza pridnenih i pelagičnih vrsta u osjetljivim staništima; te opisivanje interakcija unutar populacija i zajednica i 4) predlaganje adekvatnih mjera za buduću zaštitu i upravljanje bazirano na stečenom znanju o ekološko osjetljivim područjima te stanju glavnih populacija i zajednica.  Krajnji cilj Projekta je unaprijediti znanje o ekološko osjetljivim područjima komercijalno važnih vrsta, međusobnim odnosima u tim područjima te dati znanstvenu podlogu kako bi se osigurala dugotrajna stabilnost i očuvanje živih morskih resursa uvažavajući, kako integritet ekosustava u cjelini, tako i socio-ekonomske aspekte ribarstva kao grane gospodarstva.]]></summary_hr><summary_en><![CDATA[Biological renewable resources in the Adriatic are composed mainly from demersal and pelagic fish, crustacean and cephalopods. Status of their population size, strongly depends on the intensity of exploration as well as on the intensity of recruitment because in general, sustainability of population depends on successful recruitment of young fish in nursery areas and migration from nursery areas to the other areas of distribution inhabited by adult fraction of the population. Hence, an evidence-based understanding of the distribution noted areas is required to improve management activities related to the protection of marine resources.The main goal of the proposed Project is to identify the ecologically sensitive areas of commercially important demersal and pelagic species in the Adriatic, describe population and community statuses within, as well as detect main ecological parameters crucial for development and recruitment.Project specific objectives are: 1) critical review of existing data regarding spawning and nursery features of exploited demersal and pelagic stocks and existing fisheries regulation with gap analysis; 2) identification of ecologically sensitive areas for main commercial species; 3) improvement of knowledge about the status of marine communities in the ecologically sensitive areas, intra- and  interspecies interactions and status of the most important populations; 4) proposing measures for future adequate management of the renewable marine resources based on gained knowledge on their ecologically sensitive areas and interactions streaming to ecosystem approach in the fisheries. The overall objective is to improve knowledge on ecologically sensitive areas of commercially exploited species, inter and intra-species relationships within, to establish scientific platform in order to achieve conservation and long-term sustainable use of marine living resources in a manner that respects both integrity of ecosystems and the socio-economic interests.]]></summary_en></project><project>
<id>7843</id><title_hr><![CDATA[Potpora vrhunskim istraživanjima Centra izvrsnosti za napredne materijale i senzore]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3688</user_id><user_firstLast_name>Mile Ivanda</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-6519</code><acronim><![CDATA[]]></acronim><duration>12.10.2018 - 13.12.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>25316</team_members_id><team_members_names><![CDATA[ Doktorand: Kamran ali Syed  ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>7846</id><title_hr><![CDATA[Znanstveni centar izvrsnosti STIM REI]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6077</user_id><user_firstLast_name>Damir Kovačić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-8031</code><acronim><![CDATA[]]></acronim><duration>19.12.2018 - 31.03.2023</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Science]]></institution_en><team_members_id>25445</team_members_id><team_members_names><![CDATA[ Doktorand: Boris Delipetar ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>7847</id><title_hr><![CDATA[Mjeriteljska infrastruktura za pametne mreže]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3230</user_id><user_firstLast_name>Goran Petrović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-5902</code><acronim><![CDATA[SMAGRIMET]]></acronim><duration>01.11.2018 - 31.10.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Fakultet elektrotehnike, strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Electrical Engineering, Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>25330</team_members_id><team_members_names><![CDATA[ Doktorand: Antonijo Kunac ]]></team_members_names><keywords_hr><![CDATA[Pametne mreže, mjeriteljstvo, precizne mjerne metode, mjerenje snage, mjerenje energije]]></keywords_hr><keywords_en><![CDATA[Smart grid, metrology, precise measurement methods, measurement of power, measurement of energy]]></keywords_en><summary_hr><![CDATA[Cilj ovog projekta je izgradnja nacionalne mjeriteljske infrastrukture za podršku Smart Grid tehnologiji, koja u potpunosti nedostaje u trenutnoj hrvatskoj mjeriteljskoj infrastrukturi. Nedostaje čak i nacionalni etalon za snagu i energiju. SMAGRIMET će biti glavni centar za istraživanje i razvoj potrebne mjeriteljske infrastrukture u Republici Hrvatskoj za smart grid i srodna znanstvena područja koji će učinkovito premostiti jaz između hrvatske i europske mjeriteljske infrastrukture. Većina europskih mjeriteljskih instituta sudjelovala je u projektu razvoja Smart Grid mjeriteljske infrastrukture u kojem Hrvatska nije sudjelovala zbog nedostatka infrastrukture za mjerenje snage i energije i povezanih istraživanja vezana za pametne mreže. Istraživanje u ovom projektu će biti usmjereno na razvoj vrlo preciznih naponskih i strujnih mjernih pretvornika, pomoću analogno digitalnih pretvornika i koristeći nove algoritme za preciznu analizu mjernih podataka. Ovaj istraživački projekt će adresirati niz mjeriteljskih izazova koji će pružiti neophodnu podršku kako bi se osigurala sigurnost opskrbe električnom energijom i stabilnost mreže. Izazovi su mnogi: Mjerni okvir za nadzor i stabilnost pametne mreže, sljedivost mjerenja na udaljenim lokacijama energetske infrastrukture koji osiguravaju pravednu trgovinu energijom, daljinsko mjerenje u energetskim postrojenjima i kućanstvima, kvalitetu i učinkovitost energije te modeliranje, simulacija i analiza stanja pametne mreže. Također, uvođenje novog standarda IEC 61850 će promijeniti način na koji će trafostanica funkcionirati u budućnosti, a novi izazovi i rješenja tek trebaju biti istraženi i razvijeni. ]]></summary_hr><summary_en><![CDATA[The aim of this project is to build national metrology infrastructure to support smart grid technology and research, as it is completely lacking in the current Croatian metrology infrastructure. Even, the power and energy national standard is missing.The SMAGRIMET will be main centre for research and development of necessary metrological infrastructure in Croatia for smart grid and related scientific fields that will effectively bridge the gap between the Croatian metrological infrastructure and European counterparts. Most of the European metrological institutes have contributed to the European Smart grid metrology project in which Croatia has not taken part because of the lack of infrastructure for measuring power and energy and related issues related to smart grids.The research will be focused in developing highly accurate voltage and current transducers, using precision sampling devices and using new algorithms to accurately analyse measurement data.This research project addresses a series of metrological challenges that will provide essential support to ensure security of electricity supply and grid stability, grid quality, and fair trade between commercial parties employing the grid. The challenges are many: Measurement framework for monitoring stability of smart grids, traceable on-site energy measurement systems for ensuring fair energy trade, remote on-site measurement of power quality and efficiency and modelling, simulation and network analysis of the system state of smart grids-. Also the introduction of the new standard IEC 61850 will change the way the substation will function in the future. The standard makes new challenges and solutions have yet to be researched and developed.]]></summary_en></project><project>
<id>7852</id><title_hr><![CDATA[Od nusproizvoda u preradi žitarica i uljarica do funkcionalne hrane primjenom inovativnih procesa]]></title_hr><title_en><![CDATA[]]></title_en><user_id>19368</user_id><user_firstLast_name>Dubravka Novotni</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-2894</code><acronim><![CDATA[GbP-FFood]]></acronim><duration>22.10.2018 - 22.10.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Prehrambena tehnologija, </scie_field_hr><scie_field_en>Food technology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Food Technology and Biotechnology]]></institution_en><team_members_id>25326</team_members_id><team_members_names><![CDATA[ Doktorand: Matea  Habuš ]]></team_members_names><keywords_hr><![CDATA[nusproizvodi žitarica i uljarica, mikronizacija, ultrazvuk visokog intenziteta, enzimska hidroliza, nutritivni profil, funkcionalna hrana]]></keywords_hr><keywords_en><![CDATA[cereal and oilseed byproducts, micronization, high intensity ultrasound, enzimatic hydrolysis, nutritive profile, functional food]]></keywords_en><summary_hr><![CDATA[Suvremena prehrana je često nutritivno siromašna, a energetski bogata, što uzrokuje razne kronične bolesti. Unatoč tome, konvencionalna prerada biljnih kultura uobičajeno rezultira značajnom količinom nutritivno vrijednih nusproizvoda, kao što su posije žitarica i pogače uljarica, koje se uglavnom koriste kao stočna hrana. Primjenom spomenutih nusproizvoda u ljudskoj prehrani mogao bi se povećati unos vlakana, visokovrijednih proteina, esencijalnih masnih kiselina, mineralnih tvari, vitamina te raznih bioaktivnih spojeva koji mogu doprinijeti zdravlju. Jedan od razloga njihovog nedovoljnog iskorištenja u prehrani ljudi je slab interes potrošača, kao i narušena kvaliteta i trajnost prehrambenih proizvoda u koje se dodaju. Dodatno, upitna je i biološka iskoristivost navedenih nutrijenata, budući da se bioaktivni spojevi i mineralne tvari nalaze vezani u kompleksnim polimernim matriksima, a vlakna su većinom netopljiva.   Zbog svega navedenog se u okviru ovog projekta želi istražiti mogućnost maksimalnog iskorištenja makro- i mikronutrijenata te bioaktivnih sastojaka iz nusproizvoda mljevenja žitarica i proizvodnje ulja, uz osiguranje kvalitete krajnijih proizvoda. U tu svrhu provelo bi se fino usitnjavanje (10-30 µm) posija žitarica (pšenice, ječma, prosa i heljde) i pogača uljarica (buče, uljane repice, lana i sikavice) pri niskim temperaturama, obrada ultrazvukom visokog intenziteta te prirodna fermentacija sa ili bez dodatka enzima. Kombinacijom ovih tretmana očekuje se povećanje udjela slobodnih bioaktivnih spojeva te probavljivosti makro- i mikronutrijenata čime bi se moglo pospješiti njihovo djelovanje in vivo. Krajnji cilj projekta je optimizacija netoplinskih procesa obrade nusproizvoda žitarica i uljarica za dobivanje stabilnog i prehrambeno vrijednog materijala koji bi bio primjenjiv za obogaćivanje pekarskih i brašneno-konditorskih proizvoda i proizvoda namijenjenih osobama s posebnim prehrambenim potrebama.]]></summary_hr><summary_en><![CDATA[Modern diet is often based on nutritionally poor foods rich in energy, thus leading to different chronic diseases. Despite, conventional processing of plant foods results in significant amount of byproducts such as cereal bran and oilseed cakes, which are often used as an animal feed. Utilization of mentioned byproducts could result in increased daily intake of fibres, valuable proteins, essential fatty acids, minerals, vitamins, and different bioactive compounds, which can contribute to the human health. One reason of the insufficient utilization is low consumers interest, as well as impaired quality and shelf life of food products with added byproducts. Additionally, bioavailability of byproducts constituents is questionable, since bioactive compounds and minerals are mostly found in bound form in a complex polymer matrix, while fibres are mostly insoluble.  Thus, the aim of this project is the highest possible utilization of macro- and micronutrients and bioactive compounds from byproducts of industrial grain processing, together with preservation of the final products quality. For that reason, outer layers of cereal grains (wheat, barley, millet and buckwheat) and oilseed cakes (pumpkin seed, rapeseed, flax seed and milk thistle) will be milled to superfine particle size (10 – 30 µm), treated with high intensity ultrasound and spontaneously fermented with or without enzyme addition. The expected outcome of combined treatments is an increase of free bioactive compounds and digestibility of macro- and micronutrients, which could lead to their increased in vivo activity. Final goal of the project is optimisation of nonthermal processing of grain byproducts in order to obtain stable and nutritionally valuable material which can be used for enrichment of bakery and cereal based confectionary products and food for special dietary needs.   ]]></summary_en></project><project>
<id>7853</id><title_hr><![CDATA[Centar za napredne laserske tehnike, jedinica Plazmene tehnologije, Laboratorij za obradu materijala plazmom]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1271</user_id><user_firstLast_name>Nikša Krstulović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-2630</code><acronim><![CDATA[]]></acronim><duration>01.03.2019 - 31.12.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut za fiziku]]></institution_hr><institution_en><![CDATA[Institute of Physics in Zagreb]]></institution_en><team_members_id>25721</team_members_id><team_members_names><![CDATA[ Doktorand: Julio Car ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>7855</id><title_hr><![CDATA[BBI-IA-DEMO Growing Advanced Industrial Crops on Marginal Lands for Biorafineris]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5606</user_id><user_firstLast_name>Neven Voća</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-1777</code><acronim><![CDATA[]]></acronim><duration>14.09.2018 - 13.09.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Agronomski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Agriculture]]></institution_en><team_members_id>25226</team_members_id><team_members_names><![CDATA[ Doktorand: Anamarija Peter ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>7856</id><title_hr><![CDATA[Advanced solution for assuring the overal authenticity and quality of olive oil (Napredna rješenja osiguranja sveukupne autentičnosti i kvalitete maslinovih ulja)]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5679</user_id><user_firstLast_name>Karolina Brkić Bubola</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-4693</code><acronim><![CDATA[]]></acronim><duration>01.08.2018 - 31.07.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Prehrambena tehnologija, </scie_field_hr><scie_field_en>Food technology, </scie_field_en><institution_hr><![CDATA[Institut za poljoprivredu i turizam]]></institution_hr><institution_en><![CDATA[Institute of Agriculture and Tourism in Poreč]]></institution_en><team_members_id>25232</team_members_id><team_members_names><![CDATA[ Doktorand: Anja Novoselić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>7857</id><title_hr><![CDATA[Iznad Nyquistove granice]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6991</user_id><user_firstLast_name>Davor Petrinović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-2976</code><acronim><![CDATA[BeyondLimit]]></acronim><duration>01.10.2019 - 10.12.2023</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>28913</team_members_id><team_members_names><![CDATA[ Doktorand: Anita Gribl Gribl ]]></team_members_names><keywords_hr><![CDATA[pod-Nyquistovsko uzorkovanje, sažimajuće očitavanje, kauzalni splajnovi, rijetke reprezentacije, adaptivni valići, napredni dizajn sustava]]></keywords_hr><keywords_en><![CDATA[sub-Nyquist sampling, compressive sensing, causal splines, sparse representations, adaptive wavelets, advanced system design]]></keywords_en><summary_hr><![CDATA[Moderne informacijske i komunikacijske tehnologije suočene su s nizom izazova. Među njima izdvojili smo dva važna: ogromnu količinu podataka koja dolazi iz realnog svijeta putem senzora, kao i snagu računala potrebnu za njihovu obradu. U ovom projektnom prijedlogu smo se usmjerili na oba navedena izazova, kao i na napredne primjene ponuđenih rješenja.Desetljećima, Nyquistova granica postavlja doseg rada digitalnih elektroničkih sustava koji djeluju u analognom svijetu. Korištenjem našeg prethodnog istraživanja u području kauzalnih splajnova, adaptivnih valića, rijetkih reprezentacija te naprednog dizajna sustava, razvit ćemo originalni sustav koji radi iznad Nyquistove granice. Pod-Nyquistovsko uzorkovanje u uniji analognih potprostora te sažimajuće očitavanje su područja istraživanja korištena za postizanje ovog cilja. Obje tehnike rezultiraju aplikacijama koje idu preko poznatih granica: rezultiraju u novim tehnikama prikupljanja i obrade slika, naprednim radarskim i sonarskim uređajima, širokopojasnom programski definiranom radiju, kao i naprednim sustavima za obradu govornih i audio signala. Oslanjaju se na rijetke reprezentacije signala, sofisticiranu rekonstrukciju i algoritme za obradu signala, kao i na inteligentne implementacije koje kombiniraju analogne i digitalne podsustave.Istraživači okupljeni u ovom projektnom timu imaju iskustvo u modeliranju rijetkim signalima, dizajnu naprednih analognih i digitalnih sustava, a razvili su i različite aplikacije u obradi slika, audio i govornih signala. Razvit ćemo originalan sustav iznad Nyquistove granice zasnovan na našim kauzalnim splajnovima. Koristit ćemo naše adaptivne sustave i brze L1 minimizacijske algoritme radi postizanja rijetkih reprezentacija potrebnih u sažimajućem očitavanju. Rezultati će se koristiti u dizajnu novog pod-Nyquistovog sustava, čija će se realizacija oslanjati na naš napredni dizajn. Razvit ćemo aplikacije u obradi 3D signala, slika te obradi audio i govornih signala.]]></summary_hr><summary_en><![CDATA[Modern information and communication technologies face various challenges. We identified two of them as important: huge amount of data delivered from the real world via sensing devices, and computing power required for its processing. Both challenges are targeted in our project proposal, as well as some advanced applications of the proposed solutions.For decades, Nyquist limit sets the achievable work range of digital electronic systems operating in an analogue world. Using our previous research and expertise in causal splines, adaptive wavelets, sparse representations, and advanced system design, we will develop an original system that works beyond the Nyquist limit. Sub-Nyquist sampling in a union of analogue subspaces and compressive sensing are research topics used to achieve this goal. Both approaches result in applications that go beyond the known limits: they result in novel imaging techniques, advanced radar and sonar devices, wide-band software defined radios, as well as in advanced speech and audio processing systems. They rely on sparse representation of signals, sophisticated reconstruction and signal processing algorithms, as well as on intelligent hardware implementations that mix analogue and digital subsystems. The researchers gathered in this project team have research experience in causal splines, adaptive wavelets and sparse signal modeling, as well as in design of advanced analogue and digital systems. They have developed various applications in image, audio and speech signal processing. We will develop an original beyond Nyquist system based on our causal splines. We will use our adaptive systems and fast L1 minimization algorithms to achieve sparse representations needed in compressive sensing. The results will be used in design of novel sub-Nyquist systems, whose realization will rely on our advanced system design. We will develop its applications in 3D, image, audio and speech signal processing.]]></summary_en></project><project>
<id>7858</id><title_hr><![CDATA[Podrijetlo, ponašanje i modeliranje transporta nitrata u varaždinskom aluvijalnom vodonosniku]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5844</user_id><user_firstLast_name>Tamara Marković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-8417</code><acronim><![CDATA[TRANITAL]]></acronim><duration>01.09.2018 - 31.08.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Rudarstvo, nafta i geološko inženjerstvo, </scie_field_hr><scie_field_en>Mining, petroleum and geological engineering, </scie_field_en><institution_hr><![CDATA[Hrvatski geološki institut]]></institution_hr><institution_en><![CDATA[Croatian Geological Survey]]></institution_en><team_members_id>25213</team_members_id><team_members_names><![CDATA[ Doktorand: Igor Karlović ]]></team_members_names><keywords_hr><![CDATA[nitrat, kakvoća podzemne vode, stabilni izotopi, model transporta, aluvijalni vodonosnik]]></keywords_hr><keywords_en><![CDATA[nitrate, groundwater quality, stable isotopes, transport model, alluvial aquifer]]></keywords_en><summary_hr><![CDATA[Nitrat je spoj dušika koji se javlja u prirodni te se pojavljuje u umjerenim koncentracijama u brojnim vodenim sustavima. Visoke koncentracije nitrata su posljedica antropogene aktivnosti. Visoke koncentracije nitrata pojavljuju se u aluvijalnom vodonosniku na području grada Varaždina. Područje istraživanja zahvaća slivna područja crpilišta &#39;&#39;Varaždin&#39;&#39; i &#39;&#39;Vinokoščak&#39;&#39;. Istraživanja koja su provedene na području istraživanja s obzirom na probleme nitrata, su ili iz hidrogeološkog ili poljoprivrednog gledišta. Na području istraživanja nikada nije provedeno sustavno interdisciplinarno istraživanje ponašanja i raspodjele nitrata u vodonosniku koje bi uključivalo različite istraživače iz različitih disciplina, te različite tehnike istraživanja denitrifikacijskih i nitrifikacijskih procesa u vodonosnom sustavu. Šest je glavnih ciljeva TRANITAL projekta:1. Razviti multi-parameterski pristup za određivanje značajki aluvijalnog vodonosnika pomoću hidrauličkih, kemijskih, isotopnih i mikrobioloških pokazatelja2. Odrediti ulogu površinskih voda na napajanje/dreniranje aluvijalnog vodonosnika i njihov utjecaj na koncentraciju dušika u aluvijalnom vodonosniku3. Odrediti mineraloška i kemijska svojstva tla i njegov utjecaj na dušikov ciklus4. Određivanje podrijetla nitrata i procesa koji mogu dovesti do poboljšanja kakvoće podzemne vode5. Načiniti model toka podzemne vode i transporta nitrata u aluvijalnom vodonosniku6. Prenijeti spoznaje o podrijetlu, ponašanju i transportu nitrata u aluvijalnom vodonosnikuGlavni cilj TRANITAL projekta je osigurati znanstveno opravdani pristup i prijenos znanja između znanstvenika iz različitih disciplina koji će istraživati vodonosnike čija je kakvoća narušena zbog visokih koncentracija nitrata te prenijeti znanje upravi, planerima, vodnim grupacijama na lokalnoj i državnoj razini kako bi se osiguralo ekološko održivo upravljanje vodnim resursima i poljoprivrednom proizvodnjom.]]></summary_hr><summary_en><![CDATA[Nitrate is a compound of nitrogen that occurs naturally in moderate concentrations in many aquatic environments. Higher concentrations of nitrate in groundwater are typically caused by anthropogenic activities. High nitrate content is in groundwater of the surrounding area of the town Varaždin. The research area compromise the catchment area of the pumping sites ‘’Varaždin’’ and ‘’Vinokoščak’’. The studies that have been conducted in the research area considering the nitrate problems are from hydrogeological or agricultural point of view. In the research area there were never conducted systematic interdisciplinary research on fate and distribution of nitrate in the aquifer which would include different type of researchers, different techniques of studying denitrification and nitrification processes in the system such as aquifer. There are 6 main objectives in TRANITAL project:1.	To developed multi-parametric approach to characterize alluvial aquifer hydraulic properties and groundwater chemical, isotopic and microbiological properties. 2.	To define the role of surface waters on aquifer recharge and nitrogen cycle. 3.	To define the soil’s mineral and chemical and microbiological properties and its role in nitrogen cycle. 4.	To identify the sources of nitrate that causes the groundwater deterioration and the processes that may assist in groundwater natural attenuation. 5.	To create flow and nitrate transport numerical model of the alluvial aquifer. 6.	Transfer of knowledge about nitrate origin, fate and transport in the alluvial aquifer. The main goal of the TRANITAL project is to provide scientifically justified approach and transfer of knowledge between scientists of different disciplines which will study aquifers with high nitrate concentrations which deteriorate groundwater quality and to transfer the knowledge to decision makers and local water-use groups to ensure environmentally sustainable management of water resources and agricultural production.]]></summary_en></project><project>
<id>7859</id><title_hr><![CDATA[Molekularni biljezi vulnerabilnosti, adaptacije i plastičnosti neurona u akutnoj i kroničnoj ozljedi mozga]]></title_hr><title_en><![CDATA[]]></title_en><user_id>12600</user_id><user_firstLast_name>Svjetlana Kalanj Bognar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-3508</code><acronim><![CDATA[NeuroReact]]></acronim><duration>01.10.2018 - 31.03.2023</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>23338</team_members_id><team_members_names><![CDATA[ Doktorand: Mario Stojanović ]]></team_members_names><keywords_hr><![CDATA[selektivna vulnerabilnost neurona, hipokampus, mali mozak, glikolipidom, plastičnost, neurodegeneracija]]></keywords_hr><keywords_en><![CDATA[selective neuronal vulnerability, hippocampus, cerebellum, glycolipidome, plasticity, neurodegeneration]]></keywords_en><summary_hr><![CDATA[Više od 165 milijuna ljudi u Europi boluje od poremećaja koji zahvaćaju živčani sustav. Izrazito opterećenje za bolesnika i zdravstveni sustav predstavljaju bolesti kojima je zajednička neurodegeneracija. Neuroni pokazuju selektivnu vulnerabilnost, a intrigantna je razlika u odgovoru na raznovrsne nokse između velikog i malog mozga. Naša je hipoteza da različiti tipovi stanica u mozgu sadrže prepoznatljiv molekularni „potpis“ koji ih čini više ili manje osjetljivima i koji sudjeluje u odgovoru na patološki proces. Cilj projekta je utvrditi u kolikoj mjeri su za selektivnu vulnerabilnost neurona odgovorni zajednički učinci ekspresije određenih proteina i njihovog lipidnog miljea, odnosno postoje li specifične promjene sastava i ekspresije membranskih glikolipida i proteina koje se mogu povezati s patogenezom neurodegeneracije u stanjima akutne i kronične ozljede mozga. Fokusirat ćemo se na analizu neurona hipokampusa i malog mozga u stanjima hiperekscitabilnosti, hipoksične lezije i Alzheimerovoj bolesti. U istraživanju će biti korišteni ljudski uzorci, tkivo mišjih modela i stanični model, čiji će specifični glikolipidomski profili biti povezani s rezultatima transkriptomske, proteomske, elektrofiziološke i morfološke analize. Projekt je nastavak naših istraživanja koja su dokazala: promjene sastava i metabolizma gangliozida u Alzheimerovoj bolesti u mozgu i perifernim tkivima; utjecaj sastava moždanih gangliozida na ekspresiju membranskih proteina uključenih u sinaptičku plastičnost i transport iona, u mišjem modelu čijim fenotipom dominira degeneracija aksona i sklonost konvulzijama. U ovoj studiji ćemo usporediti ekspresiju glikolipida i izabranih proteina u dvije regije mozga s različitim odgovorom na neurodegeneraciju, stoga očekujemo da će istraživanje olakšati prepoznavanje specifičnih molekularnih biljega vulnerabilnosti i adaptacije neurona. Hipotetski je moguće modulirati aktivnost molekula-biljega i pospješiti funkcionalnu prilagodbu tkiva na ozljedu.  ]]></summary_hr><summary_en><![CDATA[Nervous system disorders affect more than 165 million people in Europe. Diseases sharing neurodegeneration as a common pathological feature present a particularly big burden for patients and public health. Neurons are selectively vulnerable and there is intriguing difference between cerebral and cerebellar neurons responding to pathological stimuli. We hypothesize that different neuronal types contain recognizable molecular “signature” making them more or less susceptible and which is involved in tissue response to lesion. The aim of the project is to estimate combined effects of specific membrane proteins expression and their lipid environment on selective neuronal vulnerability, i.e. to determine whether specific changes in membrane glycolipid and protein composition and expression may be related to neurodegenerative pathogenic events. We will focus on the analysis of hippocampal and cerebellar neurons affected by hyperexcitability, hypoxia and Alzheimer’s disease. Glycolipidomic profile of selected regions derived from human and mouse models brain and cellular model will be associated with results of detailed transcriptomic, proteomic, electrophysiological and morphological analysis. Project is based on our previous research showing: changes of ganglioside composition and metabolism in brain and peripheral tissues in Alzheimer’s disease; influence of brain ganglioside composition on expression of membrane proteins involved in synaptic plasticity and ion transport in mouse model with phenotype characterized by axonal degeneration and susceptibility to convulsions. In this study, we will compare the expression of glycolipids and selected proteins in two brain regions responding/reacting differently to neurodegeneration. We expect that such an approach will enable recognition of specific molecular markers of neuronal vulnerability and adaptation. Hypothetically, modulating the activity of these molecular markers may contribute to functional tissue adaptation.]]></summary_en></project><project>
<id>7860</id><title_hr><![CDATA[Napredni senzorski sustavi za precizno navodnjavanje u krškom krajobrazu]]></title_hr><title_en><![CDATA[]]></title_en><user_id>18912</user_id><user_firstLast_name>Vedran Bilas</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-6012</code><acronim><![CDATA[SENSIRRIKA]]></acronim><duration>01.09.2018 - 01.04.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>25240</team_members_id><team_members_names><![CDATA[ Doktorand: Marko Gazivoda ]]></team_members_names><keywords_hr><![CDATA[senzori, niska cijena, niska potrošnja, tlo, biljka, voda, poljoprivreda, Mediteran, održivost]]></keywords_hr><keywords_en><![CDATA[sensors, low-cost, low power, soil, plant, water, agriculture, Mediterranean, sustainability]]></keywords_en><summary_hr><![CDATA[Krški krajobraz je poljoprivredni potencijal primorskih i otočnih područja, posebice za proizvodnju grožđa i maslina. Unatoč povoljnim klimatskim uvjetima, uslijed konfiguracije terena i strukture tla oborinske vode se ne zadržavaju u gornjim slojevima. Izvori vode u ovim krajevima su vrlo oskudni pa je njeno racionalno korištenje za navodnjavanje osobito važno. Precizno navodnjavanje primjenjuje potrebnu količinu vode na pravom mjestu i u pravo vrijeme čime raste kvaliteta plodova, smanjuju se troškovi i čuva okoliš. Za precizno navodnjavanje treba poznavati čimbenike tla, zraka i biljke te njihovu prostornu i vremensku promjenjivost. Opći cilj ovog projekta je doprinijeti održivosti poljoprivrede na mediteranskom kršu izloženom vodnom stresu. Vodna ravnoteža krškog tla se radi heterogenosti ne može odrediti komercijalnim senzorima te je prvi dio istraživanja usmjeren na razvoj naprednog elektromagnetskog senzora vlažnosti tla. Drugi dio istraživanja odnosi se na ekonomične senzore za motrenje vodne ravnoteže biljke koju treba određivati u gustom rasporedu radi prostorne varijabilnosti tla. Senzori koriste energiju iz okoline i iznimno su male potrošnje. Izvedeni su kao senzorski čvorovi bežične mreže čime se omogućuje fuzija senzorskih podataka cjelovite površine. Sustav je zasnovan na otvorenim komunikacijskim tehnologijama radi proširivosti i nadogradnje. Treći dio istraživanja odnosi se na agronomsku validaciju podataka demonstracijskog senzorskog sustava. U istraživanjima ćemo koristiti iskustva u navodnjavanju krških vinograda i maslinika, modeliranju elektromagnetskih svojstava tla i dizajnu naprednih elektromagnetskih senzora, primjeni bežičnih senzorskih mreža u poljoprivredi, projektiranju senzorskih sučelja s iznimno malom potrošnjom, razvoju napajanja energijom iz okoline te razvoju umreženih ugradbenih sustava. Razvijeno rješenje ćemo demonstrirati u stvarnim uvjetima i prenijeti znanja i iskustva na stručnu javnosti i industriju. ]]></summary_hr><summary_en><![CDATA[Karst landscapes can provide cultivated land in Adriatic coast and islands, especially for grapevine and olive trees. The area benefits from Mediterranean climate, but due to terrain configuration and soil structure, rain water percolates rapidly downward. As freshwater sources are very scarce, their rational use for irrigation is of the greatest importance. Precision irrigation (PI) refers to application of accurately assessed volume of water at right place and time to improve crops quality, reduce costs and preserve environment. Implementation of PI requires knowledge of soil, air and plant factors in space and time. The overall objective of this project is to contribute to sustainability of agriculture in karst Mediterranean landscape providing water stress information for PI. Due to coarse nature of karst soil, its water balance cannot be estimated by commercial root zone soil moisture sensors. First part of the research aims to development of an advanced electromagnetic (EM) karst soil moisture sensor. Second part of the research refers to cost-effective sensors for plant water balance monitoring that need to be densely deployed due to high within-field variability of soil. The sensors are ultra low power and use energy harvesting. They form wireless sensor network providing sensor data integration over field area. The network uses open communication technologies enabling scalability and upgrading. In third part of the research data from a field demonstrator are agronomically validated. In this project we will use our expertise in irrigation of karst; modelling of EM soil properties and design of advanced EM sensors; application of wireless sensor networks in agriculture; and design of ultra low power sensor interfaces, energy harvesting systems and networked embedded systems. We will demonstrate the developed system in field and transfer the knowledge and experiences to professional community and industry.]]></summary_en></project><project>
<id>7862</id><title_hr><![CDATA[Geoprostorno praćenje zelene infrastrukture na temelju terestričkih, zračnih i satelitskih snimaka]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3207</user_id><user_firstLast_name>Damir Medak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-3278</code><acronim><![CDATA[GEMINI]]></acronim><duration>01.10.2018 - 30.08.2019</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Geodezija, </scie_field_hr><scie_field_en>Geodesy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Geodetski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Geodesy]]></institution_en><team_members_id>25463</team_members_id><team_members_names><![CDATA[ Doktorand: Mihael Galinac ]]></team_members_names><keywords_hr><![CDATA[geoinformatika, zelena infrastruktura, fotogrametrija, daljinska istraživanja, geostatistika]]></keywords_hr><keywords_en><![CDATA[geoinformatics, green infrastructure, photogrammetry, remote sensing, geostatistics]]></keywords_en><summary_hr><![CDATA[Zelena infrastruktura je mreža prirodnih i izgrađenih područja, objekata i zelenih površina u ruralnom i urbanom prostoru koja omogućuje društvu održivo zdravo okružje za svakodnevni život. Satelitska daljinska istraživanja predstavljaju ključni izvor podataka za kartiranje takvih okružja, ali nisu dovoljna za njihovo potpuno razumijevanje, jer zelena infrastruktura također sadrži i vertikalne strukture kao što su zelene terase i balkoni koje nije moguće snimiti vertikalnim satelitskim opažanjima. Nijedan pojedinačni izvor podataka nije dovoljan kako bi se kvalitetno kartiralo, pratilo, modeliralo i na kraju razumjelo i upravljalo interakcijom s takvim urbanim sustavima. Beskontaktno snimanje uz pomoć bespilotnih letjelica značajno proširuje mogućnosti prikupljanja dodatnih informacija potrebnih za praćenje zelene infrastrukture unutar urbanih područja na brz i jednostavan način. Glavni cilj ovog istraživačkog projekta je u ispitivanju i uspostavi inovativnog, više­dimenzionalnog sustava praćenja urbane zelene infrastrukture, koji integrira najnovije mogućnosti pridobivanja statičkih i dinamičkih multispektralnih informacija (satelitske snimke, zračne i terestričke snimke), naprednih prostornih analiza sa svrhom unapređenja sustava upravljanja i odlučivanja o zelenim gradskim područjima. S obzirom na trenutno stanje i značaj istraživane problematike, očekivani rezultati projekta omogućit će značajno tehnološko i metodološko unapređenje sadašnjih sustava upravljanja ZI u Hrvatskoj i Europi. Područje istraživanja obuhvaća urbano područje grada Zagreba s naglaskom na zaštićena zelena područja. Istraživanje se temelji na geoprostornim tehnologijama i metodama: daljinska istraživanja i geoinformacijski sustavi omogućit će integraciju utemeljenu na standardima Otvorenog geoprostornog konzorcija. Klasifikacija, određivanje granica objekata i ostale metode daljinskih istraživanja bit će temeljene na terestričkim, zračnim i satelitskim multispektralnim snimkama.]]></summary_hr><summary_en><![CDATA[Green infrastructure (GI) is a network of natural and semi-natural areas, features and green spaces in rural and urban areas that collectively provide society sustainable healthy living environment. Satellite remote sensing technology provides a key data source for mapping such environments, but is not sufficient for fully understanding them, because GI also comprise vertical structures like green terraces and balconies that are not detectable by perpendicular satellite imagery. No single data source is sufficient to satisfy the information needs required to map, monitor, model, and ultimately understand and manage our interaction within such urban systems. Unmanned Aerial Vehicles (UAV) based remote sensing offers great possibilities to acquire field data for monitoring of GI within the urban areas in a fast and easy way. The main objective of this research project is to establish an innovative, multidimensional system for monitoring of urban green infrastructure, which integrates the latest means of data collection (multispectral satellite imagery improved and calibrated with high resolution terrestrial and airborne multispectral sources), advanced spatial analysis with the aim to improve decision support system for better management of urban GI. Taking in the account current state of the art and the importance of research topic, the results of the project will significantly improve the technology and methodology of current management techniques of GI in Croatia as well as Europe.The proposed study area is the urban area of the city of Zagreb with focus on protected green areas inside the city. The research will be based on geospatial technologies and techniques: Remote Sensing and GIS tools and recommend a holistic integration of these technologies within the language of Open Geospatial Consortium (OGC) standards. Classification, object detection and other remote sensing methods will be based on the terrestrial, airborne and satellite multispectral imagery.]]></summary_en></project><project>
<id>7864</id><title_hr><![CDATA[CROSS BOrder management of variable renewable energies and storage units enabling a transnational Wholesale market — CROSSBOW]]></title_hr><title_en><![CDATA[]]></title_en><user_id>7162</user_id><user_firstLast_name>Hrvoje Pandžić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-4852</code><acronim><![CDATA[]]></acronim><duration>18.10.2018 - 01.08.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>25372</team_members_id><team_members_names><![CDATA[ Doktorand: Marija Miletić Miletić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>7866</id><title_hr><![CDATA[Matične stanice usne šupljine čovjeka za liječenje ishemijske bolesti mozga]]></title_hr><title_en><![CDATA[]]></title_en><user_id>12653</user_id><user_firstLast_name>Dinko Mitrečić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-8783</code><acronim><![CDATA[ORASTEM]]></acronim><duration>01.10.2018 - 31.03.2023</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>25391</team_members_id><team_members_names><![CDATA[ Doktorand: Valentina Hribljan ]]></team_members_names><keywords_hr><![CDATA[moždani udar, matične stanice, sluznica usne šupljine, regenerativna medicina, transkriptom ]]></keywords_hr><keywords_en><![CDATA[stroke, stem cells, oral mucosa, regenerative medicine, transriptome]]></keywords_en><summary_hr><![CDATA[Ishemijska ozljeda mozga je najčešći oblik moždanog udara te predstavlja jedan od najvećih medicinskih problema čovječanstva. U ovom projektu ćemo po prvi put istražiti terapijski potencijal nedavno otkrivenih ektodermalnih matičnih stanica ljudske sluznice usne šupljine (SOS) na modelu ishemije mozga miša. U preliminarnim pokusima smo pokazali da se ove stanice lako dobivaju iz sluznice usne šupljine pacijenta, a zbog svojeg ektodermalnog podrijetla daju živčane i glija stanice. Nakon dobivanja stanica u suradnji sa Stomatološkim fakultetom u Zagrebu, analizirat ćemo njihovo umnažanje, diferencijacijski potencijal i preživljenje tijekom rasta in vitro. Biljege diferencijacije ćemo analizirati RT-PCRom i imunohistokemijom u periodu od 14 dana, a rezultati dobiveni u normalnim uvjetima će se usporediti sa onima u uvjetima hipoksije. Razlike u odgovoru stanica na ishemiju će biti analizirane na razini transkriptoma koja će biti učinjena u suradnji s New York University Abu Dhabi. U idućoj grupi pokusa ćemo transplantirati SOS u mišji model moždanog udara. U dvije vremenske točke, 7 i 30 dana nakon transplantacije ćemo opisati njihovo preživljenje, migraciju i diferencijaciju. Miševi tretirani mišjim živčanim matičnm stanicama, ljudskim stanicama sluznice usne šupljine te netretirani miševi će biti uspoređeni - oslikani na magnetnoj rezonanci (Bruker 7T) i praćeni u nizu testova zdravstvenog statusa. Na taj način ćemo zaključiti o brzini njihovog oporavka. Očekujemo da će matične stanice usne šupljine čovjeka zbog svojeg podrijetla, pozitivnih rezultata na modelima neurodegeneracije i ozljede te naših preliminarnih rezultata pokazati visok potencijal za liječenje ishemijske bolesti mozga. Ukoliko se naša hipoteza potvrdi, ove će stanice zbog svoje dostupnosti, ektodermalnog podrijetla i terapijskog potencijala biti predložene kao stanice prvog izbora u kliničkim pokusima na pacijentima oboljelima od moždanog udara. ]]></summary_hr><summary_en><![CDATA[Ischemic brain damage is the most common form of stroke and represents one of the largest medical problems of the human society. In this project we will, for the first time, analyze therapeutic potential of recently discovered ectodermal stem cells from the oral mucosa (hOMSC) for treatment of brain ischemia. In preliminary experiments we have shown that hOMSC can be easily isolated from the mouth cavity of the patients and because of their origin – they give rise to neurons and glia. After isolation of cells, in collaboration with University of Zagreb School of Dentistry, we will analyze cell proliferation, differentiation potential and survival during cultivation in vitro . We will analyze markers of differentiation by immunhistochemistry and RT PCR in the period of 14 days and results obtained in normal conditions will be compared to in vitro hypoxia. Difference in cell response will be additionally analyzed on the level of transcriptome  which will be performed by New York University Abu Dhabi. In the next group of experiments we will transplant hOMSC in the animal model of stroke. In two time points, 7 and 30 days after transplantation we will describe their survival, migration and differentiation. Mice treated by hOMSC, NSC and untreated group will be tested in standardized tests of mouse Health status and imaged on MRI (Bruker, 7T). This will allow to conclude about histological and functional recovery of tested mice. We expect that, based on their embryonic origin, positive results on animal models of neurodegeneration and nerve damage and our promising preliminary results, hOMSC will exhibit beneficial effects for animals affected by stroke. If our hypothesis will be confirmed, hOMSC will be, because of their easy access, ectodermal origin and therapeutic potential, suggested as the perfect candidate for clinical trials on patients affected by stroke. ]]></summary_en></project><project>
<id>7867</id><title_hr><![CDATA[Cultural Heritage and Identities of Europe&#39;s Future (CHIEF 770464-2)]]></title_hr><title_en><![CDATA[]]></title_en><user_id>24257</user_id><user_firstLast_name>Benjamin Perasović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-3250</code><acronim><![CDATA[]]></acronim><duration>01.09.2018 - 01.09.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Sociologija, </scie_field_hr><scie_field_en>Sociology, </scie_field_en><institution_hr><![CDATA[Institut društvenih znanosti Ivo Pilar]]></institution_hr><institution_en><![CDATA[Institute of Social Sciences Ivo Pilar in Zagreb]]></institution_en><team_members_id>20100</team_members_id><team_members_names><![CDATA[ Doktorand: Dino Vukušić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>7868</id><title_hr><![CDATA[Inovativne tehnike u minimalnoj preradi krumpira (Solanum tuberosum) i njegova zdravstvena ispravnost nakon pripreme]]></title_hr><title_en><![CDATA[]]></title_en><user_id>2644</user_id><user_firstLast_name>Branka Levaj</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-3563</code><acronim><![CDATA[IMPROvePOTATO]]></acronim><duration>01.10.2018 - 01.10.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Prehrambena tehnologija, </scie_field_hr><scie_field_en>Food technology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Food Technology and Biotechnology]]></institution_en><team_members_id>25271</team_members_id><team_members_names><![CDATA[ Doktorand: Zdenka Pelaić ]]></team_members_names><keywords_hr><![CDATA[minimalno prerađeni krumpir, visoki hidrostatski tlak, ultraljubičasto svjetlo, ultrazvuk , akrilamid, piliciklički aromatski ugljikovodici]]></keywords_hr><keywords_en><![CDATA[minimally processed potatoes, high hydrostatic pressure, ultraviolet light, ultrasound, acrylamide, polycyclic aromatic hydrocarbons]]></keywords_en><summary_hr><![CDATA[Krumpir (Solanum tuberosum) je široko raspstranjeno povrće, vrlo često u prehrani ljudi, prikladno za skladištenje u neprerađenom stanju i do jedne godine. Kompleksnog je kemijskog sastava podložnog promjenama ovisno o uvjetima i duljini skladištenja. Priprema se za jelo na različite načine pri čemu, također, dolazi do određenih poželjnih i nepoželjnih promjena u kemijskom sastavu. U Hrvatskoj se krumpir većinom plasira na tržište neprerađeni ili u manjoj mjeri prerađen u čips i sl. snack proizvode. U drugim zemljama prerada krumpira je u porastu pri čemu minimalno prerađeni krumpir - MPK (oguljen, opran, narezan, zapakiran, toplinski neobrađen) postaje sve traženiji. Iako vrlo praktičan, takav proizvod je kratkog vijeka trajanja (uobičajeno 7 dana) i sklon je posmeđivanju te je vrlo zahtjevan za proizvodnju i čuvanje (pri temperaturi ne višoj od 8oC). Cilj ovog projekta je stjecanje spoznaja koje bi pomogle u proizvodnji MPK. Konkretnije stjecanje znanja o kemijskom sastavu različitih sorata krumpira i njegovim promjenama tijekom skladištenja te o načinima sprječavanja enzimskog posmeđivanja narezanog krumpira, stjecanju spoznaja o mogućim utjecajima na održavanje poželjnog kemijskog sastava u cilju smanjenja nastanka nepoželjnog akrilamida usljed prženja i pečenja krumpira te o načinu provedbe prženja da udjel policikličkih aromatskih ugljikovodika koji putem ulja dospijevaju u prženi krumpir bude minimalan. Nadalje, cilj je stjecanje spoznaja o utjecaju netoplinskih tehnologija (ultrazvuka visokog intenziteta - UZV, visokog hidrostatskog pritiska - HHP i ultraljubičastvog svjetla - UV-C) na kemijski sastav i posljedično na stabilnost MPK pri različitim uvjetima čuvanja. Konačni cilj je optimiranje proizvodnje MPK što uključuje definiranje optimalne sorte, postupka za sprječavanje posmeđivanja (s ili bez UZV), ambalaže i uvjeta pakiranja, te primjene netoplinskih tretmana (HHP i UV-C) u svrhu produljenja trajnosti te mogućnosti čuvanja pri sobnoj temperaturi.]]></summary_hr><summary_en><![CDATA[Potato (Solanum tuberosum) is a widespread vegetable, often used in human diet, suitable for storage as unprocessed up to one year. It has a complex chemical composition susceptible to changes depending on the conditions and duration of storage. It could be prepared for consumption in many ways by which favorable or unfavorable changes in the chemical composition also occur. In Croatia, the majority of potatoes is marketed unprocessed or, to a lesser extent, processed as chips and similar snacks. In other countries, processing of potatoes is increasing with minimally processed potatoes - MPP (peeled, washed, sliced, packaged, untreated by heat) becoming more popular. Although very convenient, such product has short shelf life (usually 7 days), is susceptible to browning and very demanding for production and storage (at temperature lower than 8 °C). The aim of this project is to acquire knowledge that would help in the production of MPP, specifically on the chemical composition of different potato varieties, their changes during storage and preventing enzymatic browning of sliced potatoes. It will also deal with the effects for guarding suitable chemical composition in order to reduce the formation of undesired acrylamide, a result of potatoes frying and baking, and with the frying method that would minimize the level of polycyclic aromatic hydrocarbons from oil in the fried potatoes. Furthermore, the goal is to acquire knowledge about the impact of non-thermal technologies (high intensity ultrasound, high hydrostatic pressure and ultraviolet light) on the chemical composition and consequently the stability of the MPP at different storage conditions. The main goal is to optimize the manufacture of MPP including the selection of the optimal variety, the procedure to prevent browning, the packaging and the packaging conditions and the application of non-thermal treatment in order to prolong durability and make possible storage at room temperature.]]></summary_en></project><project>
<id>7872</id><title_hr><![CDATA[Jačanje kapaciteta CerVirVac-a (Centra izvrsnosti za virusnu imunologiju i cjepiva) za istraživanja u virusnoj imunologiji i vakcinologiji]]></title_hr><title_en><![CDATA[]]></title_en><user_id>111</user_id><user_firstLast_name>Marija Brgles</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-5088</code><acronim><![CDATA[]]></acronim><duration>29.10.2018 - 25.09.2019</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu]]></institution_hr><institution_en><![CDATA[University of Zagreb]]></institution_en><team_members_id>25333</team_members_id><team_members_names><![CDATA[ Doktorand: Ana Vlašić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>7873</id><title_hr><![CDATA[Reprogramiranje citoprotektivnih puteva u mezoteliomu]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5915</user_id><user_firstLast_name>Sven Seiwerth</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-4788</code><acronim><![CDATA[ReprogrammingMM]]></acronim><duration>15.10.2018 - 14.10.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Clinical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>25311</team_members_id><team_members_names><![CDATA[ Doktorand: Sunčana Sikirić ]]></team_members_names><keywords_hr><![CDATA[matične stanice, pluripotencija, reprogramiranje, mezoteliom, citoprotekcija, onkogeni]]></keywords_hr><keywords_en><![CDATA[stem cells, pluripotency, reprogramming, malignant mesothelioma, cytoprotection, oncogenes]]></keywords_en><summary_hr><![CDATA[Vjeruje se da je evolucija malignih tumora stohastički proces potaknut mutacijama koje uzrokuju aktivaciju i inaktivaciju glavnih gena kojima tumorske stanice stječu fenotipske prednosti pred normalnim stanicama što im omogućava proliferaciju, lokalnu migraciju i metastaziranje. Svježi podaci ukazuju da su neke od osnovnih značajki malignosti jednake normalnim pocesima u embrionalnom razvoju koji je programiran i precizno reguliran. Subpopulacija tumorskih stanica koja pokazuje svojstva pluripotentnih stanica, tzv. tumorske matične stanice, imaju bitnu ulogu u rezistenciji na radio- i kemoterapiju, mirovanje tumora te metastaziranje. Mi ćemo proučavati maligne karakteristike mezotelioma koje su potaknute programiranim procesima povezanim s regulacijom pluripotentnosti i koje mogu biti modificirane vanjskim djelovanjem. Opća hipoteza je da je rezistencija na oksidativni stres i kemoterapiju u stanicama mezotelioma regulirana onkogenim putem PI3K/AKT/BCL2. Istražit će se može li se ovaj put kontrolirati glavnim regulatorima pluripotencije i diferencijacije uz pomoć reprogramiranja. Stanice mezotelioma će se reprogramirati u pluripotentno stanje uvođenjem specifičnih čimbenika tvoreći inducirane pluripotentne mezoteliomske matične stanice. Dobivene stanice će se diferencirati u tri linije. Ovo će nam omogućiti da odredimo može li ovakva eksperimentalna perturbacija smanjti aktivnost onkogenog puta PI3K/AKT/BCL2 koji bi mogao kontrolirati mitohondrijske citoprotektivne puteve. Konačno takva intervencija može stanice učiniti osjetljivijima na oksidativni stres i kemoterapeutike. In vitro studije će biti poduprijete s klinički relevantnim histopatološkim ispitivanjem tumora pacijenata u kojem ćemo usporediti diferencijacijski status, aktivnost PI3K/AKT/BCL2 puta i preživljenje pacijenata. ]]></summary_hr><summary_en><![CDATA[It is generally believed that the evolution of a cancer is a stochastic process of mutation-induced activation and inactivation of principal genes by which tumor cells acquire phenotypic advantages over normal cells allowing them to proliferate and migrate locally and to remote organs. Recent data indicate that some of key features of malignancy are similar to normal processes of embryonic development, which are programmed and highly regulated. The subpopulation of cancer cells that exhibit properties of embryonic stem cells are called cancer stem cells (CSCs) and studies showed their essential role in resistance to radio- and chemotherapy, tumor dormancy and metastasizing. We aim to investigate malignant characteristics of mesothelioma that are driven by programmed processes associated with the regulation of pluripotency, and which can be modified by exogenous treatment. Our overall hypothesis is that the resistance to oxidative stress and chemotherapeutics in mesothelioma cells is regulated by the activity of oncogenic pathway PI3K/AKT/BCL2. It will be investigated whether this pathway can be controlled with master regulators of pluripotency and differentiation by reprogramming mesothelioma cells. Mesothelioma cells will be reprogrammed to pluripotent state with introduction of defined factors yielding induced pluripotent mesothelioma stem cells (iPMSCs). iPMSCs will be differentiated into three different lineages. This will allow us to determine whether such experimental perturbation decreases activity of the specific oncogenic pathway PI3K/AKT/BCL2 that may control mitochondrial cytoprotective pathways. Ultimately such intervention may render cells more sensitive to oxidative stress and chemotherapeutics. In vitro studies will be corroborated with clinically relevant histopathological examination of patient’s tumors where correlation among differentiation status, PI3K/AKT/BCL2 pathway activity and patient’s survival will be examined. ]]></summary_en></project><project>
<id>7874</id><title_hr><![CDATA[NRF2 na raskrižju epigenetičkog modeliranja, metabolizma i proliferacije stanice raka]]></title_hr><title_en><![CDATA[]]></title_en><user_id>11305</user_id><user_firstLast_name>Koraljka Gall Trošelj</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-5099</code><acronim><![CDATA[CrossEMPATICNRF2]]></acronim><duration>03.10.2018 - 02.10.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>25296</team_members_id><team_members_names><![CDATA[ Doktorand: Anamarija Mojzeš ]]></team_members_names><keywords_hr><![CDATA[rak, NRF2, epigenetičko modeliranj, metabolizam, proliferacija, kliničko značenje]]></keywords_hr><keywords_en><![CDATA[cancer, NRF2, epigenetic remodeling, metabolism, proliferation, clinical significance]]></keywords_en><summary_hr><![CDATA[NRF2 je čimbenik transkripcije neophodan za aktiviranje mnogih enzima Faze 2 i detoksicirajućih enzima koji su stanici potrebni za funkcionalan antioksidacijski odgovor na stres. U kontekstu kemoprevencije, NRF2 štiti zdravu stanicu od slobodnih radikala i zbog toga je koristan i stanici, i domaćinu. U kontekstu zloćudne bolesti, njegova je aktivnost korisna samo zloćudno promijenjenoj stanici. Najnoviji podaci upućuju na važnost NRF2 u reguliranju transkripcije nekih metaboličkih enzima koji su, izravno ili neizravno, uključeni u nastanak pro-proliferativnog Warburgovog učinka. Na neke se od ovih enzima može vezati kurkumin. Aktivnost NRF2 je regulirana na nekoliko razina. Razina njegove transkripcije ovisi o metiliranosti DNA njegovog promotora (ova su dva parametra negativno korelirana) i postojanju represivne trimetilacijske oznake na lizinu 27 u histonu H3 (H3K27me3). Metiltransferaza histona EZH2, odgovorna za uspostavu ove epigenetske modifikacije smatra se onkoproteinom. Međutim, rezultati studija pokazuju da je njezino ispoljavanje vrlo varijabilno, a prognostička vrijednost kontradiktorna u nekim kliničkim modelima raka (rak pluća). Kako bismo shvatili uzroke ovih razlika, pratit ćemo funkciju NRF2 in vitro, u nekoliko linija stanica raka, u mirovanju i potaknutima gladovanjem i kurkuminom, na razini: a) aktivnosti promotora NRF2; b) prisustvu micro-RNA 200-a i 200-b; c) prisutnosti biljega proliferacije Ki-67; d) prisutnoj aktivnosti dobro znanih gena koje NRF2 izravno potiče (HO-1 i NOQ-1); c) prisustvu enzima koje NRF2 potiče neizravno, a koji su izravno ili neizravno uključeni u nastanak Warburgova učinka (PKM2, SHMT2). Analiza spomenutih proteina bit će, metodom imunohistokemije, napravljena i na arhivskim uzorcima tumora glave i vrata, kako bi se njihova ispoljenost korelirala s biološkim ponašanjem tumora.]]></summary_hr><summary_en><![CDATA[NRF2 is a transcription factor needed to activate Phase II- and detoxifying enzymes which are needed for functional cellular antioxidative stress response. In a chemopreventive setting, NRF2 protects healthy cells from free radicals and is beneficial for the cell and for the host. In the setting of developed malignant disease, its activity is beneficial only for the cancer cell. The most recent data point out its importance in regulating transcription of some metabolic enzymes which are included, directly or indirectly, in the onset of pro-proliferative Warburg&#39;s effect. Some of them were shown to be targets for direct curcumin binding. NRF2 activity is regulated at several levels. Its transcription was shown to be regulated by the level of DNA promoter methylation (which negatively correlates to the level of its transcription) and suppressive trimethylated marks on lysine 27 in histone 3 (H3K27me3). The histone methyltransferase EZH2, which is responsible for establishing this epigenetic modification, is considered to be an oncogene. However, studies have shown that its expression seems to be highly variable, with opposite prognostic values in some clinical cancer models (lung cancer). For understanding these discrepancies, we will follow NRF2 functioning in vitro, in several cancer cell lines, under resting and stimulated (starvation/exposure to curcumin) conditions, at the level of: a) its promoter activity, b) the presence of microRNAs 200-a and 200-b; c) the presence of proliferation marker Ki-67; d) the presence of NRF2 bona fide targets (HO-1 i NOQ-1); c) the presence of enzymes, shown to be indirect NRF2 targets, which are directly or indirectly involved in Warburg&#39;s effect (PKM2, SHMT2). The research will be translated to a clinical setting, through immunohistochemical evaluation of the expression of previously mentioned proteins in archive samples of head and neck tumors to establish a clinical value related to the biological characteristics of the tumor.]]></summary_en></project><project>
<id>7876</id><title_hr><![CDATA[Bioraznolikost i molekularno oplemenjivanje bilja ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6613</user_id><user_firstLast_name>Dean Ban</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-6362</code><acronim><![CDATA[]]></acronim><duration>20.09.2018 - 01.12.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Institut za poljoprivredu i turizam]]></institution_hr><institution_en><![CDATA[Institute of Agriculture and Tourism in Poreč]]></institution_en><team_members_id>25268</team_members_id><team_members_names><![CDATA[ Doktorand: Iva Bažon ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>7877</id><title_hr><![CDATA[Cross-border movement of a child in the EU]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5986</user_id><user_firstLast_name>Mirela Župan</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-5001</code><acronim><![CDATA[]]></acronim><duration>03.09.2018 - 02.09.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Pravo, </scie_field_hr><scie_field_en>Law, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Pravni fakultet u Osijeku]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Law]]></institution_en><team_members_id>25205</team_members_id><team_members_names><![CDATA[ Doktorand: Martina Drventić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>7878</id><title_hr><![CDATA[Metoda usvojenih deformacija za konačne elemente slojevitih ploča i ljuski i njena primjena na probleme delaminacije ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1014</user_id><user_firstLast_name>Dragan Ribarić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-9316</code><acronim><![CDATA[ASDEL]]></acronim><duration>16.07.2018 - 15.07.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Temeljne tehničke znanosti, </scie_field_hr><scie_field_en>Basic engineering sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Građevinski fakultet u Rijeci]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Civil Engineering]]></institution_en><team_members_id>25238</team_members_id><team_members_names><![CDATA[ Doktorand: Marin Grbac ]]></team_members_names><keywords_hr><![CDATA[teorija ploča, metoda konačnih elemenata, usvojene interpolacije deformacija, uslojene ploče, uslojene ljuske, delaminacija]]></keywords_hr><keywords_en><![CDATA[plate theory, finite element method, assumed strain, layered plates, layered shells, delamination]]></keywords_en><summary_hr><![CDATA[Predlažemo istraživački projekt iz bazičnih tehničkih znanosti koji će se baviti numeričkim analizama Mindlinovih tipova umjereno debelih ploča pomoću metode konačnih elemenata. Temeljem naših dobrih rezultata kod dizajniranja četverostraničnih i trostraničnih pločastih elemenata (s različitim brojem čvorova) uz pomoć metode usvojenih interpolacija deformacija a za formuliranje njihove matrice krutosti, predlažemo proširenje istraživanja na uslojene ploče u 2D prostoru i uslojene ravne i zakrivljene ljuske u 3D prostoru.Materijal koji povezuje slojeve će se u početnoj fazi opisti elastičnim konstitutivnim zakonom, ali slijedom naših uspješnih numeričkih eksperimenata na uslojenim gredama, vezni materijal između slojeva će se u narednoj fazi opisati mješovitim konstitutivnim zakonom s kohezivnom zonom i oštećenjem. Ovaj tip povezivanja slojeva bit će kasnije primijenjen na sve tipove konstruktivnih modela – ploča, ravnih i zakrivljenih ljuski. Numerički rezultati bit će uspoređeni s rezultatima modela ili eksperimentalnim rezultatima drugih autora iz literature.Istovremeno, neka jednostavna eksperimentalna istraživanja izraditi će se s opremom iz naših laboratorija. U završnoj fazi, izvesti ćemo složene eksperimente na stvarnim modelima s delaminacijom slojeva, te i njih usporediti s odgovarajućim numeričkim modelima.]]></summary_hr><summary_en><![CDATA[We propose a research project in basic technical sciences concerning the numerical analysis of the Mindlin type moderately thick plates and shells by the finite element method.Given our good results in designing quadrilateral and the triangular plate elements (with various number of nodes) by the assumed strain interpolation in the element stiffness formulation, we propose to extend our research to the layered plates in 2D space and the layered facet or curved shells in 3D space. The material connecting the layers will be modeled at first with a simple elastic constitutive law, but following our successful numerical experiments on the layered beams, the interfaces between layers will be further modeled by a mixed-mode cohesive-zone damage-type constitutive law. This kind of interconnection behavior will be then applied to all kinds of structural models - plates, facet and curved shells. The numerical results will be compared with the other models and the experimental results from literature.At the same time, experimental research will be performed using the equipment in our laboratories. We shall try to perform experiments with delamination of the real layered models and also compare them with the appropriate numerical models.]]></summary_en></project><project>
<id>7879</id><title_hr><![CDATA[Primjena proteinskih hidrolizata iz pogača lana i konoplje u medijima za uzgoj životinjskih stanica]]></title_hr><title_en><![CDATA[]]></title_en><user_id>19708</user_id><user_firstLast_name>Igor Slivac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-6952</code><acronim><![CDATA[HYDRO PEP CELL]]></acronim><duration>01.10.2018 - 31.12.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Biotehnologija, </scie_field_hr><scie_field_en>Biotechnology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Food Technology and Biotechnology]]></institution_en><team_members_id>25193</team_members_id><team_members_names><![CDATA[ Doktorand: Marijan Logarušić ]]></team_members_names><keywords_hr><![CDATA[uljne pogače, hidrolizati proteina, kultura životinjskih stanica, medij za uzgoj, CHO stanice]]></keywords_hr><keywords_en><![CDATA[oil cake, protein hydrolysates, animal cell culture, culture media, CHO cells]]></keywords_en><summary_hr><![CDATA[Kulture životinjskih stanica koriste se za proizvodnju visokovrijednih spojeva kao što su rekombinantni proteini. Za uspješan rast, održavanje i produktivnost kultura stanica potreban je medij za uzgoj koji mora sadržavati hranjive tvari, soli, hormone, faktore rasta te serum životinjskog porijekla. Posljednjih desetljeća uočeni su problemi primjene seruma u procesima s kulturama stanica, a koji se očituju u rizicima prijenosa virusa, priona i mikoplazmi te otežanoj izolaciji proizvoda. U cilju prevladavanja nedostataka primjene seruma razvijeni mediji bez seruma koji često sadrže hidrolizate biljnog porijekla. Hidrolizati sadrže aminokiseline, oligopeptide, lipide, vitamine i ostale spojeve koji potiču proliferaciju i produktivnost stanica u kulturi.Nus-proizvodi prehrambene industrije, a među njima i ostaci iz proizvodnje jestivog ulja tzv. pogače, zbog značajnog sadržaja proteina predstavljaju novu potencijalnu sirovinu za primjenu u tehnologiji životinjskih stanica. Pogače lana i industrijske konoplje sadrže 30-35% proteina i kao takve nisu zanemariv izvor proteina koji se može koristiti kao dodatak u medijima za uzgoj životinjskih stanica. Glavni cilj predloženog Projekta jest primjena proteinskih hidrolizata pripravljenih iz pogača lana i konoplje kao dodatka medijima za uzgoj stanica (s i bez seruma). Istražit će se učinak hidrolizata na prinos proizvoda biotehnološkog postupka proizvodnje rekombinantnih proteina obzirom na proliferaciju stanica i proizvodnost. Ukoliko predložena istraživanja budu provedena, rezultati dobiveni ovim Projektom doprinijet će većem ekonomskom iskorištenju nus-proizvoda iz proizvodnje ulja lana i konoplje. Štoviše, u slučaju pozitivnog učinka hidrolizata na rast stanica i proizvodnost rekombinantnih proteina, razvijeni postupak hidrolize te strategija prihranjivanja hidrolizatima tijekom uzgoja stanica, doprinijet će tehnologiji životinjskih stanica na način da će utjecati na oblikovanje medija bez seruma. ]]></summary_hr><summary_en><![CDATA[Animal cell culture has a great importance in production of recombinant proteins. For successful maintenance of animal cell culture, it is essential to ensure culture medium which consists of various nutrients and a blood serum of animal origin. However, the addition of animal sera has always been related to complex isolation of the cell product. Therefore, in order to overcome the obstacles of serum addition, cell culture experts developed serum-free media that still show better performance with addition of protein hydrolysates, preferably of plant origin. Plant hydrolysates are reach source of peptides and amino acids as well as other growth stimulating factors. One of the most promising substances for making these hydrolysates are protein rich by-products of edible oil industry called oil cakes or oil meals. Oil-cakes of flax and industrial hemp seeds contain 30-35% proteins, and as such can be used as a nutritious media supplement for animal cell cultivation. The main objective of the proposed project is to determine the effects of flaxseed and hempseed oil cake hydrolysates on cell proliferation and recombinant protein production. We want to carry out an enzyme based oil cake hydrolysis and apply different hydrolysate fractions and concentrations in cell culture, with or without serum. Defining the parameters of hydrolysis and characterization of derived peptides is the foundation for standardization of the hydrolysate composition and their administration as nutritive supplements for cell culture. The results obtained with this project will contribute to the re-evaluation of waste-products from flax and hemp oil industry and direct their application in the field of animal technology. If positive results were achieved, (i.e. hydrolysates show stimulatory effects on cell growth and productivity), the selected hydrolysate fractions could be used as a beneficial culture media component and thus affect future media formulations.]]></summary_en></project><project>
<id>7880</id><title_hr><![CDATA[Uloga bradikinina u ishemiji mozga i mrežnice u mišjim modelima dijabetesa – BRADISCHEMIA]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6226</user_id><user_firstLast_name>Marina Radmilović (Dobrivojević)</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-7776</code><acronim><![CDATA[]]></acronim><duration>01.10.2018 - 01.03.2023</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>25294</team_members_id><team_members_names><![CDATA[ Doktorand: Anja Barić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>7882</id><title_hr><![CDATA[STIM-REI projektna aktivnost ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1118</user_id><user_firstLast_name>Frano Barbir</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-7027</code><acronim><![CDATA[]]></acronim><duration>01.11.2018 - 31.03.2023</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, </scie_field_hr><scie_field_en>Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Fakultet elektrotehnike, strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Electrical Engineering, Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>25327</team_members_id><team_members_names><![CDATA[ Doktorand: Andrej Zvonimir Tomić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>7883</id><title_hr><![CDATA[Uporaba podataka daljinskih istraživanja dobivenih različitim 3D optičkim izvorima u izmjeri šuma]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1275</user_id><user_firstLast_name>Ivan  Balenović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-6336</code><acronim><![CDATA[3D-FORINVENT]]></acronim><duration>16.07.2018 - 15.09.2021</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Šumarstvo, </scie_field_hr><scie_field_en>Forestry, </scie_field_en><institution_hr><![CDATA[Hrvatski šumarski institut]]></institution_hr><institution_en><![CDATA[Croatian Forest Research Institute]]></institution_en><team_members_id>24107</team_members_id><team_members_names><![CDATA[ Doktorand: Luka Jurjević ]]></team_members_names><keywords_hr><![CDATA[izmjera šuma, uređivanje šuma, daljinska istraživanja, digitalna fotogrametrija, GIS]]></keywords_hr><keywords_en><![CDATA[forest mensuration, forest management, remote sensing, digital photogrammetry, GIS]]></keywords_en><summary_hr><![CDATA[Šuma je najrašireniji kopneni ekosustav na Zemlji te pruža mnogo direktnih i indirektnih dobrobiti ljudskom čovječanstvu. Potrajno gospodarenje šumama uz osiguranje njenih mnogobrojnih funkcija i usluga zahtjeva prostorno određene  informacije o stanju i razvoju šume koje se uglavnom prikupljaju u okviru inventure šuma. Prikupljanje podataka o šumama na tradicionalni način, terenskom izmjerom, pruža točne informacije, ali zahtijeva dugotrajan i intenzivan rad, a u pojedinim slučajevima pristup određenim šumskim područjima je otežan ili čak nemoguć. Upravo iz tog razloga prepoznat je potencijal upotrebe metoda daljinskog istraživanja (DI) pri inventuri šuma. Unatoč dostupnosti različitih podataka DI i velikom potencijalom za njihovo korištenje pri izmjeri šuma, u Hrvatskoj, kao i u mnogim drugim zemljama, izmjera šuma se još uvijek temelji samo na tradicionalnoj terenskoj izmjeri.Stoga je glavni cilj predloženog projekta razviti i testirati metode temeljene na različitim 3D optičkim podacima DI za primjenu u inventuri šuma, a u svrhu poboljšanja učinkovitosti i ekonomičnosti postojećih terenskih načina prikupljanja podataka. Konkretno, ispitati će se točnost proizvoda (oblak točaka, DMVK, ortofoto) izvedenih iz različitih 3D podataka DI (aerosnimke, satelitske snimke, snimke bespilotne letjelice) i različitih prostornih rezolucija, za procjenu varijabli pojedinačnih stabala i šumskih sastojina na raznim prostornim razinama. Istražiti će se i mogućnost njihove primjene u automatskoj segmentaciji i klasifikaciji pojedinačnih stabala i šumskih sastojina. Općenito, a posebice u zemljama jugoistočne Europe, nedostaju komparativne studije koje se bave usporedbom podataka o šumama dobivenih iz različitih 3D optičkih senzora DI. Ovo istraživanje će dati prve informacije o kvaliteti i točnosti navedenih podataka i njihovih produkata te mogućnosti njihove primjene u inventuri šuma. Stoga, će dobiveni rezultati biti od iznimnog značaja i interesa za šumarsku znanost i praksu.]]></summary_hr><summary_en><![CDATA[As the most widely distributed terrestrial ecosystem on the earth, forests provide many direct and indirect benefits to human well-being. Sustainable management of forests’ multiple functions and services requires spatially explicit information about forests state and development, which are usually acquired through forest inventories.Although traditional field-based forest inventory can provide relatively accurate information, the process is time-consuming and labour intensive, and in some cases access to certain forest areas is not possible. Therefore, the potential of remote sensing (RS) application in forest inventory have been long recognized by both researchers and practicing foresters. Despite the availability of various RS data and great potential for their use, in Croatia as well as in many other countries, forest inventory is still based only on traditional field methods.Therefore, the main goal of this proposal is to develop and evaluate methods and workflows for forest inventory applications based on different 3D RS data, aiming to improve efficiency and cost-effectiveness of current field-based inventory practices. Specifically, the accuracy of products (image-based point cloud, CHM, orthoimage) derived from various 3D RS data (UAS, airborne, satellite stereo images) with different spatial resolutions will be evaluated for estimating the main tree and forest stand attributes at various spatial levels. Secondly, automatic segmentation and classification of both individual trees and forest stands using above mentioned products will be investigated. A comparison studies dealing with performance of different 3D RS data in forest inventory are lacking, especially in the South-east European region. Therefore, this research will provide first assessments of quality and accuracy of forest information derived from different 3D RS data and its products. Thus, the results of this research will be of interests for both forestry researchers and industry.]]></summary_en></project><project>
<id>7884</id><title_hr><![CDATA[ERC StG 337283 MembranesAct]]></title_hr><title_en><![CDATA[]]></title_en><user_id>2682</user_id><user_firstLast_name>Ana-Sunčana Smith</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-9055</code><acronim><![CDATA[]]></acronim><duration>01.11.2018 - 01.08.2021</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Interdisciplinarne prirodne znanosti, </scie_field_hr><scie_field_en>Interdisciplinary natural sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>25340</team_members_id><team_members_names><![CDATA[ Doktorand: Josip Augustin Janeš ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>7886</id><title_hr><![CDATA[Procjena atmosverskog taloženja i razine ozona u mediteranskim šumskim ekosustavima]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6636</user_id><user_firstLast_name>Tamara Jakovljević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-9483</code><acronim><![CDATA[DepOMedFor]]></acronim><duration>01.12.2018 - 31.10.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Šumarstvo, </scie_field_hr><scie_field_en>Forestry, </scie_field_en><institution_hr><![CDATA[Hrvatski šumarski institut]]></institution_hr><institution_en><![CDATA[Croatian Forest Research Institute]]></institution_en><team_members_id>25412</team_members_id><team_members_names><![CDATA[ Doktorand: Lucija Lovreškov ]]></team_members_names><keywords_hr><![CDATA[atmosfersko taloženje, ozon, mediteranski šumski ekosustav, procjena, praćenje]]></keywords_hr><keywords_en><![CDATA[atmospheric deposition, ozone, mediterranean forest ecosystems, assessment, monitoring]]></keywords_en><summary_hr><![CDATA[Šumski ekosustavi se odlikuju izrazito promijenjivim uvjetima za rast i razvoja. Mediteranska regija čini se da je najosjetljivija na globalne promjene i atmosferske utjecaje. Mediteranski šumski ekosustavi su od velike važnosti zbog ekoloških funkcija koje pružaju. Rizik od utjecaja atmosferskih taloženja, erozija, klizišta i poplava je tako visok. Ovi faktori rizika u kombinaciji s klimatskim promjenama  vjerojatno utječu na ciklus nutrienta i hranidbe vrijednosti, vlažnost tla i, u konačnici, na rast i primarnu produktivnosti. Predloženo istraživanje će dati jedinstvenu mogućnost za analizu ne samo biogeokemijskim ciklus elemenata, na lokalnoj razini, nego i procjenu utjecaja onečišćenja na dijelove šumskog ekosusstava, te tijek od izvora do receptora. Da bi ostvarili ciljeve projekta uspostavit će se plohe za praćenje atmosferskih taloženje i razine ozonski na kojima će se vršti mjerenja mjeriti zajedno drugim varijablama, uključujući one koji se odnose na tlo i lišće te hranjiva, zdravstveni satus stabla, rast i stanje krošnje u kombinaciji s meteorološkim podacima. Mi ćemo dobiti potpuno nove, ali potrebne informacije koje nedostaju o atmosferskom taloženju, statusu hranjivih tvari, stvarnim opterećenjima, razini ozona i njegovih učinaka na šumama. Dodane vrijednosti ovog istraživanja će biti ispunjavanja praznina u znanju o naših mediteranskim šumskim ekosustavima i nadogradnju stečenog znanja s različitim statističkim metodama i budućih predviđanja kako bi se procijenilo stanje mediteranskih šumskih ekosustava. Rezultata ovog istraživanja i suradnje s talijanskim i francuski znanstvenim institucijama doprinijeti će široj osvrtu na utjecaje atmosferilija na mediteranske šumske ekosustave istočne obale Jadrana na regionalnoj i Europskoj razini.]]></summary_hr><summary_en><![CDATA[Forest ecosystems are characterized by strongly ?uctuating conditions for tree growth and development. The Mediterranean region appears to be the most vulnerable to global change and atmospheric inputs. Mediterranean forest ecosystems are of very high significance because of ecological functions they provide. The risk of impacts of atmospheric inputs, erosion, landslides and floods is being so high in this region. These risk factors combined with climate change is likely to affect nutrient turnover and nutrient availability, soil moisture and, ultimately, growth and primary productivity. The proposed research will give the unique possibility to analyse not only the biogeochemical cycle of elements, at local scale, but also the assessment of the environmental impact of pollutants on forest ecosystems compartments, following the uptake and the fate, from the sources to the receptors. In order to accomplish project objectives the monitoring plots will be established and atmospheric deposition and ozone levels will be measured together with a suite of other variables including those related to soil and foliar nutrient, tree health, growth and crown condition combined with meteorological data. We will get completely new but necessary missing information on atmospheric deposition, nutrient status, actual loads and ozone levels and its effects on forests. The added values of this research will be filling the gap in knowledge of our Mediterranean forest ecosystems and upgrading the gained knowledge with different statistical methods and future predictions in order to assess the condition of Mediterranean forest ecosystems.The results of this research and collaboration with Italian and French scientific institutions will contribute to the wider overview on impacts of atmospheric inputs in Mediterranean forests ecosystem of Eastern Adriatic coast at the regional and European level.]]></summary_en></project><project>
<id>7887</id><title_hr><![CDATA[Bioprospecting Jadranskog mora]]></title_hr><title_en><![CDATA[]]></title_en><user_id>993</user_id><user_firstLast_name>Bono Lučić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-9531</code><acronim><![CDATA[]]></acronim><duration>04.10.2018 - 04.01.2021</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>25287</team_members_id><team_members_names><![CDATA[ Doktorand: Viktor Bojović ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>7888</id><title_hr><![CDATA[Različiti učinci okolišno relevantnih mješavina metal temeljenih nanočestica i pesticida na faunu tla: Nove smjernice za procjenu rizika]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6027</user_id><user_firstLast_name>Branimir Hackenberger Kutuzović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-4257</code><acronim><![CDATA[DEFENSoil]]></acronim><duration>17.07.2018 - 16.07.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Odjel za biologiju]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Department of Biology]]></institution_en><team_members_id>25219</team_members_id><team_members_names><![CDATA[ Doktorand: Marija Kovačević ]]></team_members_names><keywords_hr><![CDATA[metal temeljene nanočestice, toksičnost mješavina, procjena okolišnog rizika, fauna tla, gujavice, ekotoksikologija]]></keywords_hr><keywords_en><![CDATA[metal based nanoparticles, mixture toxicity, environmental risk assessment, soil fauna, earthworm, ecotoxicology]]></keywords_en><summary_hr><![CDATA[Tlo je neobnovljivi prirodni resurs karakteriziran mnogobrojnim procesima koji se uvelike mijenjaju kao posljedica povećanog antropogenog pritiska na okoliš. Pravilno i stabilno funkcioniranje tla nužan je preduvjet održivosti terestričkih ekoloških sustava, te bitan čimbenik u planiranju ljudskih aktivnosti u smislu održivog razvoja. Među brojnim zagađivalima prisutnima u okolišu pesticidi se, zbog njihove široke i uobičajene upotrebe, te utjecaja na neciljne organizme, smatraju jednima od glavnih zagađivala tla. Nanočestice (NP) su u novije vrijeme dovedene u središte pozornosti zbog sve veće zastupljenosti u poljoprivredi što naglašava važnost razumijevanja njihovih ekotoksikoloških učinaka. Cilj projektnog prijedloga je određivanje različitih učinaka mješavina NP i pesticida na neciljnim organizmima u tlu. Kako bi ostvarili navedene ciljeve predlažemo sveobuhvatno  ekotoksikološko istraživanje koje uključuje različite razine složenosti (preliminarna laboratorijska-eksperimenti u ograničenim okolišnim uvjetima), različite krajnje točke (molekularna-populacijska razina), različite scenarije izlaganja (jedan toksikant–mješavina, kratko-dugačko izlaganje, jednostruko–niz izlaganja) i uključivanje modelnih i nativnih organizama tla. Na temelju složenih eksperimentalnih podataka o toksičnim učincima odabranih pesticida i NP, izraditi će se predikcijski model pogodan za optimizaciju biomonitoringa opterećenja tla, te matrični modeli učinaka na razini populacija ispitivanih organizama. Iz modela će se procijeniti učinci istraživanih toksikanata, te odrediti uvjeti pod kojima modelirana populacija pruža odgovor na aplicirane toksikante i mijenja svoj potencijal odgovora na druge stresore. Očekivani rezultati poboljšati će znanje o toksičnosti smjesa na neciljne organizme tla, te o mogućim utjecajima i ekotoksikološkim karakteristikama metal temeljenih NP što će biti primjenjivo u procesu procjene okolišnog rizika pogodnim za tehnološki suvremene načine korištenja tla. ]]></summary_hr><summary_en><![CDATA[Soil is a non-renewable resource subjected to a series of degradation processes and increasing environmental pressure, driven or exacerbated by human activity. As the appropriate functioning of the soil is essential for terrestrial ecosystems and human activity the risk of its impairment should be taken very seriously. Among numerous pollutants present in the environment, pesticides, due to their wide and common usage and impact on non-target organisms, represent one of the major soil pollutants. More recently nanoparticles (NPs) have been brought into focus as the increased interest for their usage in agriculture highlights the importance of understanding its ecotoxicological effects. The proposed project aims to identify the various effects of NPs and pesticides mixtures on non-targeted soil organisms, but also to identify the interactions of metal-based NPs and pesticides. In order to deliver the specified objectives of the project we propose a comprehensive ecotoxicological research which includes various levels of complexity (from preliminary laboratory to semi-field experiments), different endpoints (from molecular to population level), different exposure scenarios (single-mixture, short-long, single application-sequence of applications) and inclusion of both model and native soil organisms. Additionally, based on experimental data on toxic effects of selected pesticides and metal-based NPs, population-level matrix models will be constructed. From the model outputs the effects of investigated toxicants will be assessed and used to establish under which set of conditions a modelled population will respond to applied toxicants and alter its potential to respond to other stressors. The expected results will improve the state of knowledge on toxicity of mixtures on non-targeted soil organisms and can be implemented in risk assessment process. Consequently, expected results can enhance soil protection and soil ecological sustainability.]]></summary_en></project><project>
<id>7890</id><title_hr><![CDATA[Genotip-fenotip korelacija u Alportovom sindromu i nefropatiji tankih glomerularnih bazalnim membrana]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3902</user_id><user_firstLast_name>Danica Galešić Ljubanović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-8957</code><acronim><![CDATA[GPofASandTBMN]]></acronim><duration>01.10.2018 - 30.09.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Clinical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>24835</team_members_id><team_members_names><![CDATA[ Doktorand: Matija Horaček ]]></team_members_names><keywords_hr><![CDATA[Alportov sindrom, nefropatija tankih glomerularnih bazalnih membrana, COL4A3, COL4A4, COL4A5, genotip-fenotip korelacija]]></keywords_hr><keywords_en><![CDATA[Alport’s syndrome, Thin Glomerular Basement Membrane Nephropathy, COL4A3, COL4A4, COL4A5, genotype-phenotype correlation]]></keywords_en><summary_hr><![CDATA[Alportov sindrom (AS) i nefropatija tankih glomerularnih bazalnih membrana (TBMN) su genetski heterogeni, strukturalni poremećaji glomerularne bazalne membrane (GBM). Genetska osnova obaju poremećaja je u mutaciji gena koji kodiraju izoforme kolegena tipa IV.  Glavni simptom u oba poremećaja (AS i TBMN) je hematurija, a glavna razlika je u kliničkom tijeku i progresiji bolesti. Razlikovanje AS i TBMN je važno, ali ponekad komplicirano. Planiramo provesti multidisciplinarno, kolaborativno istraživanje na nacionalnoj razini, u kojem će sudjelovati sedam vodećih hrvatskih nefroloških, pedijatrijsko-nefroloških i nefropatoloških institucija (Klinička bolnica Dubrava,  Klinička bolnica Merkur, Klinički bolnički centri Zagreb, Rijeka i Split, Klinički bolnički centar Sestre Milosrdnice, Zagreb i Klinika za dječje bolesti, Zagreb). Prikupit ćemo kliničke podatke o bubrežnim i izvanbubrežnim simptomima, histološke podatke (uključujući bojenje za lance kolagena tipa IV) i provesti studiju obitelji za AS i TBMN pacijente u Hrvatskoj. U svrhu otkrivanja mutacija gena COL4A5, COL4A4 i COL4A3 koristit ćemo kombinirani pristup - multipleks PCR amplifikaciju, kvantifikaciju amplikona  i  sekvenciranje slijedeće generacije (eng. next generation sequencing). Ove analize će biti provedene u molekularnom laboratoriju Zavoda za patologiju i Centru za translacijska i klinička istraživanja Medicinskog fakulteta Sveučilišta u Zagrebu. Glavni cilj istraživanja je utvrditi prevalenciju AS i TBMN u Hrvatskoj i razjasniti AS i TBMN histološki, genetski i klinički. Naš krajnji cilj je stvoriti Hrvatski  registar AS i TBMN pacijenta s kliničkim, histološkim i genetskim podacima te podacima o praćenju pacijenata. Voditelj projekta je izv.prof.dr.sc. Danica Galešić Ljubanović, a uz nju, na projektu će sudjelovati 20 znanstvenika.]]></summary_hr><summary_en><![CDATA[Alport&#39;s syndrome (AS) and thin basement membrane nephropathy (TBMN) are genetically heterogenic, structural disorders of glomerular basement membrane (GBM). Genetic base of both disorders lies in mutation of genes which encode isoforms of collagen type IV. Major symptom of both disorders (AS and TBMN) is hematuria, and the main difference between them, is clinical course and progression of the disease. The distinction between AS and TBMN is important but may be difficult. Our plan is to conduct multidisciplinary, nationwide, collaborative research in which seven leading Croatian nephrology, pediatric nephrology and nephropathology institutions (Dubrava University Hospital Zagreb, Merkur University Hospital Zagreb, University Hospital Centers Zagreb, Rijeka and Split, University Hospital Center Sisters of Mercy, Zagreb and Children&#39;s Hospital Zagreb) will participate.  We plan to collect clinical data, about both renal and extra-renal symptoms, histological data (including staining for collagen IV chains), as well as, family study data on Croatian AS and TBMN patients.  The combined approach of multiplex PCR amplification, amplicon quantification, and next generation sequencing for COL4A5, COL4A4 and COL4A3 gene mutation screening will be done at molecular laboratory at Department of Pathology and Center for Translational Research, University of Zagreb. School of Medicine. Main goal of our research is to identify prevalence of AS and TBMN in Croatia and to clarify these two entities histologically, genetically and clinically. Our ultimate goal is to create AS and TBMN patients&#39; registry with clinical, histological, genetic and follow up information. Project leader is Associate Professor Danica Galešić Ljubanović, and beside her, on project will work 20 scientists.]]></summary_en></project><project>
<id>7892</id><title_hr><![CDATA[Računalno učinkovito upravljanje učinskim pretvaračima u mikromrežama]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5578</user_id><user_firstLast_name>Jadranko Matuško</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-6395</code><acronim><![CDATA[PowerCon2]]></acronim><duration>01.11.2018 - 31.10.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>25380</team_members_id><team_members_names><![CDATA[ Doktorand: Renato Babojelić ]]></team_members_names><keywords_hr><![CDATA[ Učinski pretvarači, Mikromreža, Modelsko prediktivno upravljanje, Izravno upravljanje snagom, FPGA]]></keywords_hr><keywords_en><![CDATA[Power converters, microgrid, Model predictive control, Direct power control, FPGA]]></keywords_en><summary_hr><![CDATA[Sve veći udio obnovljivih izvora u proizvodnji električne energije doveo je to pojave koncepta mikromreže. Mikromreža predstavlja skupinu distribuiranih i međusobno povezanih izvora, potrošača i spremnika energije i koja kao entitet može raditi spojena na distribucijsku mrežu ili potpuno odvojena od nje, tj. u tzv otočnom režimu rada. Tehnologija koja omogućuje jedan takav fleksibilan koncept su učinski pretvarači koji osiguravaju učinkovit i upravljan tok energije unutar mikromreže kao i prema distribucijskoj mreži. U zadnjoj dekadi modelsko prediktivno upravljanje se pojavilo kao metodologija koja omogućuje ne samo poboljšanje učinkovitosti rada učinskih pretvarača već i da se na sustavan način u proces projektiranja sustava upravljanja ugrade svi operativni zahtjevi, zahvaljujući jedinstvenom svojstvu da omogućava optimiranje radom sustava prema željenoj funkciji cilja, poštujući pritom sva ograničenja sustava. Glavna prepreka široj primjeni modelskog prediktivnog upravljanja u energetskim pretvaračima su značajni računski zahtjevi algoritma.Ovaj projekt ima za cilj razvoj računalno učinkovitih algoritama upravljanja mrežnim učinskim pretvaračima prikladnim za implementaciju u stvarnom vremenu. Projektni ciljevi su sljedeći: (i) razvoj računalno učinkovitog algoritma prediktivnog upravljanja mrežnim učinskim pretvaračem s PWM modulatorom, (ii) razvoj računalno učinkovitog algoritma prediktivnog izravnog upravljanja snagom mrežnog učinskog pretvarača (DPC) i (iii) implementacija i testiranje razvijenih algoritama na FPGA sklopovlju. Svi razvijeni algoritmi će biti implementirani  i testirani u istosmjernoj mikromreži u Laboratoriju za obnovljive izvore na Falultetu elektrotehnike i računarstva (LARES) ]]></summary_hr><summary_en><![CDATA[Increasing penetration of renewable sources in electricity generation has given rise to the concept of microgrids, a group of interconnected loads and distributed energy resources with clearly defined electrical boundaries that acts as a single controllable entity with respect to the grid connect and disconnect from the grid to enable it to operate in both grid-connected or islanded mode. An enabling technology for such the highly flexible concept are power converters, that allows for an efficient and well controlled energy flow within microgrid and to/from the main grid. In the last decade model predictive control has emerged as a methodology that is capable not only to further increase the efficiency of energy conversion but also to systematically integrate control and operational requirements into control system design process, owing to its unique feature to optimize system behaviour over an arbitrary objective function while respecting the system constraints at the same time. The main obstacle to broader applications of MPC based algorithms in power converters is the significant computational burden of the MPC algorithm. This project aims to develop computationally efficient algorithms for grid connected power converters suitable for real time-implementation.  In particular, the project aims: (i) to develop a computationally efficient PWM based predictive control algorithm for grid-tied power converters, (ii) to develop a computationally efficient Predictive Direct Power Control algorithm for grid-tied power converters and (iii) to implement the developed control algorithm for grid-tied power converters into high performance hardware platforms such as Field Programmable Gate Array (FPGA). All the developed control algorithms will be implemented and tested in a small scale DC microgrid in the Laboratory for Renewable Energy Sources (LARES) at Faculty of electrical Engineering and Computing, Zagreb.  ]]></summary_en></project><project>
<id>7894</id><title_hr><![CDATA[Uloga upale u razvoju zloćudnog tumora mokraćnog mjehura]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5769</user_id><user_firstLast_name>Janoš  Terzić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-1571</code><acronim><![CDATA[iBC]]></acronim><duration>21.06.2018 - 30.11.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Split School of Medicine]]></institution_en><team_members_id>19132</team_members_id><team_members_names><![CDATA[ Doktorand: Maria Bošković ]]></team_members_names><keywords_hr><![CDATA[mokraćni mjehur, rak, upala, mikrobiom, STAT3, IL-6]]></keywords_hr><keywords_en><![CDATA[bladder, cancer, inflammation, microbiome, STAT3, IL-6]]></keywords_en><summary_hr><![CDATA[Oko 20% smrtnih slučajeva od zloćudnih tumora posljedica je kronične upale. Virusne i bakterijske infekcije, infestacije parazitima, autoimunost i iritirajuće kemikalije uzrokuju upalne promjene koje stimuliraju začetak zloćudnih tumora, njihov ras i metastaziranje. Drugi istraživači i mi smo pokazali da su ključne molekularne poveznice između kronične upale i zloćudnih tumora citokin IL-6 i transkripcijski čimbenik STAT3. Postaje sve očitije da i mikrobni sastav pojedinog tkiva ima važnu ulogu u razvoju kronične upale i zloćudnih tumora. Uloga upale u patogenezi zloćudnih tumora mokraćnog mjehura (TMM) slabo je proučena iako upala izazvana sa Schistosoma haematobium potiče razvoj TMM, dok se upala uzrokovana s BCG uspješno koristi za njegovo liječenje.Za pročavanje upale u razvoju TMM koristiti ćemo najmodernije mišje modele (tzv. knock-out miševe) koijma će tumori biti inicirati s BBN-om. Analizirati ćemo: (1) ulogu IL-6 i (2) ulogu STAT3 u razvoju TMM kao i (3) terapijski potencijal STAT3 inhibitora. Nadalje planiramo (4) proučavati važnosti mikrobioma u nastanku TMM koristeći mišji model te bolesti uz upotrebu antibiotika koji će promijeniti sastav mikrobioma. Proučavajući (5) mikrobiomski sastav urina osoba s TMM i zdravih jedinki pokušati ćemo povezati određene mikrobe s TMM. Projekt proučava temeljne odlike zloćudnih tumora mokraćnog mjehura pa ukoliko se pokaže da smanjivanje aktivnosti STAT3 usporava razvoj TMM naši rezultati mogu potaknuti stvaranje novih lijekova (inhibitora STAT3) za TMM. Rezultati proučavanja mikrobioma mogu dovesti do novih preventivinih mjera (razvoja cjepiva ili upotrebe antibiotika). Kako je TMM sedmi tumor po učestalosti predloženi projekt je od velikog medicinskog, socijalnog i ekonomskog značaja. Članovi projektnog tima su iskusni istraživači su kao ključni znanstvenici objavljivali otkrića u najboljim časopisima poput Cancer Cell i Nature Genetics, što jamči uspješnu realizaciju projekta. ]]></summary_hr><summary_en><![CDATA[Around 20% of cancer deaths are a consequence of chronic inflammation. Viral and bacterial infections, parasitic infestation, autoimmunity or chemical irritants cause inflammatory changes that stimulate cancer initiation, promotion and metastasis. We and others have shown that main molecular links between inflammation and cancer are cytokine IL-6 and its transcription factor STAT3. It is becoming obvious that microbiome composition of particular niche is important element of inflammation and cancer development. The role of inflammation in urinary bladder cancer (BC) pathogenesis is poorly understood although chronic inflammation caused by Schistosoma haematobioum has pro-tumorigenic effect while acute inflammation caused by BCG is successfully used as a therapy for BC. To investigate the role of inflammation in BC development we will use BBN induced BC mice models and will study: (1) the role of IL-6 (by using IL-6 KO mice); (2) the role of STAT3 by assessing its targeted deletion in mice urothelium and (3) therapeutic potential of STAT3 inhibitor. Additionally, we plan to (4) test importance of microbiome in BC development by using mice BC model and antibiotic treatment to manipulate bladder microbiome composition and to (5) analyze human bladder cancer microbiome, in order to associate BC with specific microbiota.This project addresses fundamental questions of bladder cancerogensis. If altering STAT3 activity has inhibitory effect on BC development that finding can lead to new therapies (use of STAT3 inhibitors) for established BC. Findings generated by the microbiome analysis can lead to novel preventive measures (microbiota manipulation by antibiotics or vaccination). Team members are experienced scientist with publications in Cancer Cell and Nature Genetics which is securing successful realization of the project. Because BC is the seventh most common malignancy, proposed project is of great medical, social and economic importance.]]></summary_en></project><project>
<id>7895</id><title_hr><![CDATA[Pojavnosti moderne skulpture u Hrvatskoj: skulptura na razmeđima društveno-političkog pragmatizma, ekonomskih mogućnosti i estetske kontemplacije]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5489</user_id><user_firstLast_name>Dalibor Prančević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-6586</code><acronim><![CDATA[CROSCULPTURE]]></acronim><duration>01.10.2018 - 01.08.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Povijest umjetnosti, </scie_field_hr><scie_field_en>Art history, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>24567</team_members_id><team_members_names><![CDATA[ Doktorand: Dora Derado ]]></team_members_names><keywords_hr><![CDATA[skulptura, društvo, politika, estetika, povijest umjetnosti, centar, periferija, Hrvatska]]></keywords_hr><keywords_en><![CDATA[sculpture, society, politics, aesthetics, art history, center, periphery, Croatia]]></keywords_en><summary_hr><![CDATA[Cilj projekta je „dubinsko mapiranje“ moderne skulpture u Hrvatskoj kroz različite „prostorne“ i „vremenske“ slojeve, te sagledavanje specifičnih okolnosti unutar kojih se ona oblikovala. Kiparska produkcija u Hrvatskoj promatrala bi se ponajprije u odnosu na europsku umjetničku produkciju, istražilo bi se njezino snalaženje u neprekidnim promjenama kako državnih asocijacija tako i društveno-političkih paradigmi i politikâ identiteta, ali i nastajanje u posebnim ekonomskim prilikama. Istraživanjem bi se pratila i notirala kretanja kipara različitim europskim političkim i kulturnim geografijama. Cilj istraživačkog tima jest razviti nove metode opisivanja vremenskih, prostornih i terminoloških definicija moderne skulpture u Hrvatskoj. Fokus istraživanja kiparska je produkcija nastajala u razdoblju koje započinje na kraju 19. stoljeća i zaključuje se sedamdesetih godina 20. stoljeća. Pritom će se u razmatranje uzeti društvo, politika, ekonomija i estetika. U pripremi projektnog prijedloga uvažila se i činjenica kako je dobar dio kiparske produkcije u Hrvatskoj nastajao eksteritorijalno. Stoga bi se istraživanjem propitalo u kojoj mjeri i na koje načine su hrvatski kipari diseminirali nove pristupe angažmana u kiparstvu, koji su to specifični protagonisti i kako se i može li se kroz njihovo djelovanje postaviti okvir diskursa o „deprovincijalizaciji“ hrvatskog kulturnog prostora. Vizualizacije takvih odnosa realizirale bi se posebnim softverskim alatima, već poznatima području djelovanja digitalne humanistike. Nadalje, posebno bi se istražile i sve one pojave kiparstva isključene iz dominantnih narativa, poput primjerice rodnih pitanja. Zasebni dio projektnog prijedloga uključuje stvaranje rječnika skulpture dvadesetog stoljeća kojim bi se stvorio tezaurus termina što se vezuju uz pojavu skulpture i njezinu artikulaciju. Rezultati istraživanja bili bi predstavljeni na međunarodnim konferencijama i okruglim stolovima, te u objavljenim recenziranim radovima i knjigama.]]></summary_hr><summary_en><![CDATA[The aim of the project is to come to an “in-depth mapping” of Modern sculpture in Croatia, with regards to various „spatial“ and „time“ layers, as well as investigation of the specific context within which Modern sculpture was shaped. Sculptural production in Croatia is to be observed in relation to European art, and in the context of constant change of state associations, different socio-political paradigms and identity politics, but also in relation to the economic situation. The research also aims to trace the movement of sculptors and their work throughout various European political and cultural geographies. Research team aims to develop new descriptions of the terms of reference within time, spatial and terminological definitions of Modern sculpture in Croatia. The main research focus will be on sculptural production in the period beginning at the end of the 19th century until the 1970s. Society, politics, economy, aesthetics will be taken into consideration. During the preparation of the project proposal it became clear that a reasonable part of Croatian sculpture was created extraterritorially. This research will investigate how and to what measure Croatian sculptors disseminated new approaches to sculptural activity, who are the specific protagonists, and how is it possible to establish a discourse frame dealing with ”de-provincialisation” of Croatian cultural space. Visualisations of such relations are to be displayed using special software tools, well known in the area of digital humanities. Furthermore, the aim is to research all those phenomena in the domain of sculpture that were excluded from the dominant narratives, for example gender issues. Special part of the project includes generating 20th century sculpture vocabulary, in order to create a thesaurus of terms that are related to the manifestation of sculpture and its articulation. Research results will be presented at international conferences, via reviewed papers and in books.]]></summary_en></project><project>
<id>7896</id><title_hr><![CDATA[Genomički aspekti brze evolucije primorske gušterice (Podarcis sicula)]]></title_hr><title_en><![CDATA[]]></title_en><user_id>19008</user_id><user_firstLast_name>Anamaria Štambuk</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-8879</code><acronim><![CDATA[GENRALIZ]]></acronim><duration>10.10.2018 - 11.02.2021</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>25018</team_members_id><team_members_names><![CDATA[ Doktorand: Iva Sabolić ]]></team_members_names><keywords_hr><![CDATA[adaptivna evolucija, populacijska genomika, selekcija, evolucijska ekologija, fenotipska evolucija, Lacertidae, otoci, morfologija guštera, prehrana]]></keywords_hr><keywords_en><![CDATA[adaptive evolution, population genomics, selection, evolutionary ecology, phenotypic divergence, Lacertidae, islands, lizard morphology, diet]]></keywords_en><summary_hr><![CDATA[Sposobnost vrsta da nastanjuju nove okoliše ovisi u najvećoj mjeri o sposobnosti jedinki da se prilagode drugačijim ekološkim uvjetima. Razumijevanje mikroevolucijskih procesa koji određuju brzu adaptivnu evoluciju, kao i načina na koji selekcija oblikuje fenotipsku divergenciju u prirodnim populacijama i dalje je jedan od glavnih ciljeva evolucijske biologije. Ovaj projekt implementira dosadašnja saznanja o povijesti kolonizacije i ekološki uvjetovanoj fenotipskoj divergenciji populacija gušterice Podarcis sicula na otocima Lastovskog arhipelaga (Jadran) u istraživanje evolucijskih procesa koji uvjetuju brze fenotipske promjene u populacijama izloženim novim okolišnim uvjetima.  Ukratko, 1971. godine proveden je pokus u kojem je pet parova  gušterica P. sicula premješteno s njihovog nativnog otoka Pod Kopište na susjedni otok Pod Mrčaru. 35 godina nakon introdukcije za populaciju gušterica u novom okolišu utvrđena je nevjerojatna fenotipska divergencija u morfologiji i ekologiji, uzrokovana prijelazom s insektivorne na omnivornu prehranu. Ciljevi ovog projekta su: odrediti da li su te fenotipske promjene posljedica genetičkih promjena ili fenotipske plastičnosti, te saznati, proučavanjem dodatnih prirodnih populacija, kako fenotipska divergencija i učinak uskog grla utječu na genomičku divergenciju populacija gušterica P. sicula. Eksperimentalni i analitički okvir projekta, koji se bazira na pokusima križanja, pokusima „zajedničkog okoliša“ te populacijskoj genomici, omogućit će nam da testiramo da li 1) brzo evolvirajuća adaptivna fenotipska obilježja koja su omogućila prijelaz u prehrani gušterica s otoka Pod Mrčaru imaju genetičku osnovu, te da li su 2) jaka selekcija i učinak uskog grla  ostavili jasan otisak na genomičku divergenciju između populacija.]]></summary_hr><summary_en><![CDATA[The successful establishment of a species in novel environment depends on the capacity of individuals to cope with the novel conditions. Understanding the microevolutionary processes underlying rapid adaptive evolution and the way selection shapes phenotypic divergence in natural populations remains one of the major goals of evolutionary biology. In the proposed project we leverage the relatively well known colonisation history, and knowledge on ecologically induced phenotypic divergence of populations of the lizard Podarcis sicula that inhabit islands of the Lastovo archipelago (Adriatic) to study the evolutionary events driving rapid phenotypic shifts in populations encountering novel environments. Briefly, in 1971 a transplant experiment was conducted in which five pairs of P. sicula were introduced from their native island Pod Kopište onto a nearby islet, Pod Mrčaru. In 35 years since their introduction those populations exhibited spectacular phenotypic divergence in morphology and ecology, linked to a dietary shift from an insectivorous to an omnivorous diet. This project aims to identify if this phenotypic shift is due to genetic changes or phenotypic plasticity, and to investigate additional populations to understand how rapid phenotypic divergence and population bottlenecks influence genomic divergence amongst P. sicula populations. The experimental and analytical framework based on common garden experiments and population genomics will enable us to test whether 1) the rapidly evolved and adaptive phenotypic traits that facilitate a dietary shift in lizards from Pod Mrčaru have a genetic basis, and 2) if strong selection and population bottlenecks left distinct signatures of genomic divergence between populations.]]></summary_en></project><project>
<id>7897</id><title_hr><![CDATA[Predictive Models and Experimental Validation of Multicomponent Dense Spray Dynamics]]></title_hr><title_en><![CDATA[]]></title_en><user_id>240</user_id><user_firstLast_name>Hrvoje Jasak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-7176</code><acronim><![CDATA[]]></acronim><duration>01.10.2018 - 30.09.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, </scie_field_hr><scie_field_en>Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>25388</team_members_id><team_members_names><![CDATA[ Doktorand: Robert Keser ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>7898</id><title_hr><![CDATA[Strengthening European Food Chain Sustainability by Quality and Procurement Policy]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4466</user_id><user_firstLast_name>Irena Colić Barić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-4691</code><acronim><![CDATA[]]></acronim><duration>14.10.2018 - 14.10.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Nutricionizam, </scie_field_hr><scie_field_en>Nutrition, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Food Technology and Biotechnology]]></institution_en><team_members_id>25325</team_members_id><team_members_names><![CDATA[ Doktorand: Ana Ilić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>7901</id><title_hr><![CDATA[Network for Using BIM to Increase the Energy Performance - Net-UBIEP (Mreža za povećanje energetske učinkovitosti korištenjem BIM-a) (Project ID: 754016)]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4319</user_id><user_firstLast_name>Bojan Milovanović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-8611</code><acronim><![CDATA[]]></acronim><duration>10.10.2018 - 09.10.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Temeljne tehničke znanosti, </scie_field_hr><scie_field_en>Basic engineering sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Građevinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Civil Engineering]]></institution_en><team_members_id>25360</team_members_id><team_members_names><![CDATA[ Doktorand: Sanjin Gumbarević ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>7902</id><title_hr><![CDATA[Ispitivanje reaktivnosti trombocita u različitim srčanožilnim bolestima]]></title_hr><title_en><![CDATA[]]></title_en><user_id>7462</user_id><user_firstLast_name>Davor  Miličić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-4564</code><acronim><![CDATA[SPARELIFE-CVD]]></acronim><duration>05.04.2019 - 20.12.2019</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Clinical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>26203</team_members_id><team_members_names><![CDATA[ Doktorand: Dubravka Šipuš ]]></team_members_names><keywords_hr><![CDATA[kardiovaskularne bolesti, reaktivnost trombocita, agregometrija, personalizirana kardiologija, klinički ishodi]]></keywords_hr><keywords_en><![CDATA[cardiovascular diseases, platelet reactivity, aggregometry, personalized cardiology, clinical outcomes]]></keywords_en><summary_hr><![CDATA[Predloženi projekt je nastavak dosadašnjeg rada u kojem se nastoji ispitati značaj reaktivnosti trombocita u različitim srčanožilnim oboljenjima te mogućnost da se individualiziranom primjenom antitrombocitnih lijekova prema vrijednostima reaktivnosti trombocita poboljšaju klinički ishodi. Istraživanje je podijeljeno u pet cjelina koje će se paralelno provoditi. Prva cjelina obuhvaća nastavak istraživanja utjecaja povišene ostatne reaktivnosti trombocita i individualiziranog pristupa primjene antitrombocitne terapije u bolesnika s akutnim koronarnim sindromom. Druga cjelina će istraživati promjene reaktivnosti trombocita kod bolesnika nakon izvanbolničkog aresta koji se podvrgavaju protokolu terapijske hipotermije. Nedovoljno je istraženo kako kontrolirano snižena tjelesna temperatura utječe na agregacijsku kaskadu in vivo, osobito u bolesnika koji se liječe antitrombocitnim lijekovima. Treća cjelina će obuhvatiti bolesnike koji se liječe mehaničkom cirkulacijskom potporom zbog terminalne faze srčanog popuštanja. U toj skupini evaluirat ćemo reaktivnost trombocita povezanu s korištenjem izvantjelesnog krvotoka odnosno mehaničkih srčanih crpki i povezanost s trombozama uređaja i s krvarenjima. U četvrtoj cjelini istraživat ćemo ulogu funkcije trombocita u sekundarnoj plućnoj hipertenziji uzrokovanoj bolešću miokarda lijeve klijetke (WHO tip II). Povezanost reaktivnosti trombocita i težine bolesti je već pokazana u primarnoj plućnoj hipertenziji, ali ne i u mnogo češćoj, plućnoj hipertenziji tipa II. Rezultati bi mogli pridonijeti poznavanju patofiziologije sekundarne plućne hipertenzije tipa II s mogućim terapijskim implikacijama, jer se namjerava ispitati, moduliraju li promjene reaktivnosti trombocita vazoaktivni odgovor na prostaglandin E1. Posljednja, peta cjelina će biti posvećena ispitivanju prognostičkog značenja reaktivnosti trombocita na razvoj koronarne vaskulopatije u bolesnika nakon presadbe srca što do sada nije istraživano.]]></summary_hr><summary_en><![CDATA[The proposed project represents a continuation of our previous work which will examine the significance of platelet reactivity (PR) in a variety of cardiovascular diseases and the potential of individualized approach in antiplatelet therapy regimen based on the values of PR to improve clinical outcomes. The research will be divided into five arms that will be conducted simultaneously. The first arm will be the continuation of our research on the impact of high on-treatment platelet reactivity and individualized approach to the application of antiplatelet therapy in patients with acute coronary syndrome. The second arm will study the changes of PR in patients with out-of-hospital cardiac arrest who undergo therapeutic hypothermia protocol. It is insufficiently explored how a controlled low body temperature affects the aggregation cascade in vivo, particularly in patients treated with antiplatelet drugs. The third arm will include patients with implanted mechanical circulatory support (MCS) due to end-stage heart failure. In this group we will evaluate the association of PR levels in patients with MCS and device thromboses as well as bleeding events. In the fourth study arm we will investigate the role of platelet function in secondary pulmonary hypertension caused by left ventricular myocardial disease (WHO type II). Correlation between PR and the severity of the disease has been shown in primary pulmonary hypertension, but not in much more frequent, type II pulmonary hypertension. The results might contribute to the knowledge of the pathophysiology of pulmonary hypertension, with potential therapeutic implications as we intend to examine whether the changes in PR modulate the response to vasoactive prostaglandin E1. The last, fifth arm will be devoted to heart transplant patients where we will examine the prognostic significance of PR in the development of coronary vasculopathy after heart transplantation which has not been investigated so far.]]></summary_en></project><project>
<id>7903</id><title_hr><![CDATA[634429 ParaFishControl  Advanced Tools and Research Strategies for Parasite Control in European farmed fish]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3130</user_id><user_firstLast_name>Ivana Ujević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-5569</code><acronim><![CDATA[]]></acronim><duration>01.08.2018 - 10.12.2019</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Interdisciplinarne prirodne znanosti, </scie_field_hr><scie_field_en>Interdisciplinary natural sciences, </scie_field_en><institution_hr><![CDATA[Institut za oceanografiju i ribarstvo]]></institution_hr><institution_en><![CDATA[Institute of Oceanography and Fisheries]]></institution_en><team_members_id>25222</team_members_id><team_members_names><![CDATA[ Doktorand: Anka Pralija ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>7905</id><title_hr><![CDATA[Plan/test/coordinate Underwater Museums, Diving Parks and Knowledge Awareness Centres in order to support sustainable and responsible tourism development and promote Blue growth in coastal areas and islands of the Mediterranean (BLUEMED)]]></title_hr><title_en><![CDATA[]]></title_en><user_id>18903</user_id><user_firstLast_name>Zoran Vukić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-1727</code><acronim><![CDATA[]]></acronim><duration>01.11.2018 - 31.10.2019</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>25317</team_members_id><team_members_names><![CDATA[ Doktorand: Igor Kvasić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>7907</id><title_hr><![CDATA[1)&#39;&#39;Upgrading the research performance in molecular medicine at the Faculty of Veterinary Medicine University of Zagreb&#39;&#39; ;2)&#39;&#39;Molecular Animal Nutrition&#39;&#39;]]></title_hr><title_en><![CDATA[]]></title_en><user_id>801</user_id><user_firstLast_name>Vladimir Mrljak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-6431</code><acronim><![CDATA[]]></acronim><duration>03.09.2018 - 02.09.2022</duration><status>Završio</status><financ_value>0,13 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Veterinarska medicina, </scie_field_hr><scie_field_en>Veterinary medicine, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Veterinarski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Veterinary Medicine]]></institution_en><team_members_id>25377</team_members_id><team_members_names><![CDATA[ Doktorand: Ivana Rubić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>7929</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[Exotic Nuclear Structure and Dynamics]]></title_en><user_id>19023</user_id><user_firstLast_name>Kosuke Nomura</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>TTP</proposal_type><proposal_call>2018-07</proposal_call><code>TTP-2018-07-3554</code><acronim><![CDATA[ExoNSD]]></acronim><duration>01.05.2019 - 30.04.2024</duration><status>Završio</status><financ_value>995.421,06 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Nuclear  Structure, Exotic Nuclei, Nuclear Shapes, Collective Excitations, Fission, Nuclear Astrophysics, Fundamental Symmetries, Quantum Chemistry]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[This project will establish a leading independent research group with the aim to conduct frontier research programs to quest for the structure and dynamics of atomic nuclei. Scientific objectives will be pursued in the cutting-edge theoretical nuclear physics, that unifies mathematical modelling of complex systems and advanced scientific computing. Atomic nucleus is a self-organized quantum many-body systems of protons and neutrons. Nowadays it has become possible to access extremely short-lived (exotic) nuclei at experiments using radioactive-ion beams. The study of exotic nuclei helps deepen our understanding of the origin of matter, test fundamental symmetries in Nature, and even allows practical applications. Key questions addressed by experimental programs will also require developing advanced theoretical methods, often coupled to innovative and high-performance computer simulation techniques that also finds applications in other areas of science. The central idea of ExoNSD is to develop a novel consistent theory framework based on the nuclear energy density functional and algebraic theory. The theoretical method will be originally developed by the PI and his team, and provides unprecedented opportunity to study exotic nuclei that are being extensively investigated at experiments all over the world, but that are beyond reach of any other theoretical approach. The focus of the research will be on the exotic shapes and decay spectroscopy in nuclei far from the beta stability line, induced fission dynamics in superheavy elements, modelling astrophysical processes, fundamental physics at low energy – neutrino-less double–beta decay and CP violation, and trans-disciplinary applications in nuclear chemistry. ExoNSD also includes activities to promote the project in the scientific community, support the dissemination and publications of results, initiate new collaborations, and to strengthen the integration of Croatian science within the European Research Area.]]></summary_en></project><project>
<id>7935</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[Evolution in the dark]]></title_en><user_id>1207</user_id><user_firstLast_name>Helena Bilandžija</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>TTP</proposal_type><proposal_call>2018-07</proposal_call><code>TTP-2018-07-9675</code><acronim><![CDATA[Evodark]]></acronim><duration>01.05.2019 - 30.07.2024</duration><status>Završio</status><financ_value>1.004.784,99 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>858357, </team_members_id><team_members_names><![CDATA[Magdalena Grgić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[cave dwelling animals, the loss of pigmentation, adaptation to darkness, the evolution of novel phenotypes, convergent evolution]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[How organisms adapt to the environment and generate novel phenotypes are fundamental questions in biology. Cave adapted animals offer outstanding opportunities to answer them because the cave environment is simple, novel phenotypes evolved convergently in different phyla, and surface dwelling relatives resembling the ancestral form are available for comparative studies. I will integrate molecular, cellular, and organismal approaches to 1) explore the effect of the environment and 2) investigate the molecular origin of a major evolutionary adaptation. 1. By exposing closely related surface relatives to constant darkness in controlled laboratory conditions we can identify the adaptations in the cave forms that evolved due to the lack of light - the major feature of caves. My previous research on the fish Astyanax mexicanus showed that traits considered as cave adaptations (e.g. metabolism, stress response) can be induced by exposing the surface form to darkness.  I propose to investigate i) the molecular mechanisms that underlie these phenotypic changes in Astyanax surface fish and ii) whether darkness would induce similar changes in closely related surface relatives of cave adapted invertebrates (arthropods, planaria). 2. One of the hallmarks of cave adaptations is the loss of pigmentation, present almost ubiquitously in all groups regardless of the type of pigment they synthesize. My previous research identified a relevant molecular change in multiple cave animals with melanin pigmentation, and that natural selection as opposed to drift is likely involved. Nothing is known about the other pigments that are lost in cave animals.  Therefore, I propose to investigate the molecular and evolutionary mechanisms of ommochrome and porphyrin loss in cave adapted arthropods and planaria. Insights from these studies would provide new understanding of the mechanisms of convergent evolution and the genetic origin of novel phenotypes.]]></summary_en></project><project>
<id>7943</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[Mining the Variable Sky]]></title_en><user_id>24834</user_id><user_firstLast_name>Lovro Palaversa</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>TTP</proposal_type><proposal_call>2018-07</proposal_call><code>TTP-2018-07-1171</code><acronim><![CDATA[MVS]]></acronim><duration>01.05.2019 - 29.07.2024</duration><status>Završio</status><financ_value>956.327,56 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, Interdisciplinarne prirodne znanosti, </scie_field_hr><scie_field_en>Physics, Interdisciplinary natural sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[astronomy, astrophysics, stars, galaxies, transients, variability, machine learning ]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The aim of the &#39;&#39;Mining the Variable Sky&#39;&#39; project is to establish an independent research group that will study the history of the Galaxy and the physics driving the variability of astrophysical sources through the application of machine learning techniques. The proposed project is fully aligned to the Ruđer Bošković Institute&#39;s (RBI, the Host Institute) strategy of developing a regional centre for astronomy and astrophysics. The project would take full advantage of the RBI&#39;s status of an International Contributor to the Large Synoptic Survey Telescope.The transient and variable sky are still under-explored. Combining the results from the surveys across the electromagnetic spectrum allows us to discover and study populations of heretofore unknown transients, for example the mysterious fast radio bursts or rare transients such as the tidal disruptions of stars by supermassive black holes.  Furthermore, time-domain surveys can help in pinpointing the sources of gravitational waves by identifying their electromagnetic counterparts.In the case of more common transients like the type Ia supernovae, larger samples are required to study the expansion history of the Universe in more detail. It is therefore necessary to develop rapid and reliable classification methods that will optimize the use of the scarce follow-up resources.Complementary studies of stellar variability, in conjunction with the parallaxes provided by the Gaia mission, allow us to precisely and accurately anchor and apply luminosity-based distance estimation methods on galactic to cosmological scales, study stellar evolution and the Milky Way&#39;s history of formation and accretion. Thanks to the publicly available, state-of-the-art Gaia mission archive with 1.7-billion sources, the Galaxy can now be explored in unprecedented detail. ]]></summary_en></project><project>
<id>7960</id><title_hr><![CDATA[BioProspecting Jadranskog mora ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>206</user_id><user_firstLast_name>Zoran Herceg</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-9620</code><acronim><![CDATA[]]></acronim><duration>06.05.2019 - 04.11.2023</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Prehrambena tehnologija, </scie_field_hr><scie_field_en>Food technology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Food Technology and Biotechnology]]></institution_en><team_members_id>26346</team_members_id><team_members_names><![CDATA[ Doktorand: Mia Ivanov ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>7962</id><title_hr><![CDATA[Glikozilacija serumskog transferina kao faktor u mehanizmu prijenosa željeza]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4009</user_id><user_firstLast_name>Tin Weitner</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-1042</code><acronim><![CDATA[GlyMech]]></acronim><duration>23.04.2019 - 23.11.2023</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Farmaceutsko-biokemijski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Pharmacy and Biochemistry]]></institution_en><team_members_id>26503</team_members_id><team_members_names><![CDATA[ Doktorand: Valentina Borko ]]></team_members_names><keywords_hr><![CDATA[željezo, transferin, glikozilacija, ravnoteža, kinetika, mehanizam]]></keywords_hr><keywords_en><![CDATA[iron, transferrin, glycosylation, equilibrium, kinetics, mechanism]]></keywords_en><summary_hr><![CDATA[Projekt obuhvaća temeljno istraživanje utjecaja glikozilacije transferina, glavnog prenositelja željeza u ljudskom organizmu, na ravnotežu i kinetiku vezivanja željeza. Znanstveni ciljevi ovog projekta su: 1. određivanje konstanata ravnoteže vezivanja željeza za različite glikoforme transferina, 2. određivanje redukcijskog potencijala željeza vezanog u različitim glikoformama transferina te 3. određivanje kinetike i mehanizma vezanja i otpuštanja željeza iz različitih glikoformi transferina.Većina transferina su topljivi glikoproteini koji se sastoje od jednog lanca sa 700 aminokiselinskih ostataka i glikanskog dijela heretogene strukture i različitog sadržaja sijalinske kiseline. Tijekom fizioloških ili patofizioloških promjena u organizmu dolazi do post-translacijskih promjena u glikozilaciji transferina, pri čemu udio nesijaliniziranog transferina postaje značajno povišen. Promjene u razmjerno velikom glikanskom dijelu transferina mogu imati značajan utjecaj na konstantu vezivanja željeza te na vezivanje za transferinski receptor ciljnih stanica. Mehanizam vezivanja i otpuštanja željeza povezan je s njegovim redukcijskim potencijalom koji ovisi o različitim faktorima (npr. pH, sinergijski anion, itd.), a promjenom glikozilacije transferina također može doći i do značajne promjene redukcijskog potencijala te promjena u kinetici vezivanja ili otpuštanja željeza.Projekt osigurava preduvjete za znanstvenu izvrsnost i razvoj samostalnih istraživačkih karijera mladih znanstvenika poboljšanjem uvjeta rada u smislu opreme i drugih resursa te uklanjanja prepreka njihovoj mobilnosti. Provedbom projekta također će ojačati njihov kapacitet za povlačenje financijskih sredstava iz fondova EU i ostalih financijskih izvora te omogućiti održivost i proširenje znanstvene djelatnosti uspostavljene grupe.]]></summary_hr><summary_en><![CDATA[The proposed fundamental research of transferrin, the principal iron-transporting protein in the human body, and the impact of its glycosylation pattern on the equilibrium and kinetics of iron binding has the following scientific objectives: 1. determination of the iron-binding equilibrium constants for transferrin glycoforms, 2. determination of the reduction potential of iron bound to transferrin glycoforms, and 3. determination of the kinetics and mechanism of iron binding and release from transferrin glycoforms.Most transferrins are soluble glycoproteins consisting of a single chain of 700 amino acid residues and heterogeneous glycan structures. Physiological or pathophysiological changes in the organism lead to post-translational changes in the glycosylation of transferrin, resulting in the significantly increased levels of desialylated transferrin. Changes in relatively large glycan structures of transferrin may have a significant effect on the iron-binding constant and may also affect binding to the target cell receptors. The iron binding and release mechanism is associated with its reduction potential that depends on various factors (e.g. pH, synergic anion, etc.). Any alteration of the transferrin glycosylation pattern can result in changes in the reduction potential as well as the kinetics of iron binding or release.This project will facilitate scientific excellence and development of independent research careers of young scientists by increasing employment and improving their working conditions in terms of equipment and other resources or by removing obstacles to their mobility. Implementation of the project will also strengthen the capacity of young scientists to withdraw financial resources from EU funds and other sources and thus ensure the sustainability and expansion of the established research group’s scientific activity.]]></summary_en></project><project>
<id>7963</id><title_hr><![CDATA[Istraživanje shizofrenije kroz ekspresiju netopivih proteina]]></title_hr><title_en><![CDATA[]]></title_en><user_id>22771</user_id><user_firstLast_name>Nicholas Bradshaw</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-5395</code><acronim><![CDATA[CandidIskren]]></acronim><duration>09.10.2019 - 13.06.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Interdisciplinarno područje znanosti</scie_area_hr><scie_area_en>Interdisciplinary scientific area</scie_area_en><scie_field_hr>Biotehnologija u biomedicini, </scie_field_hr><scie_field_en>Biotechnology in Biomedicine, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Fakultet biotehnologije i razvoja lijekova]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Biotechnology and Drug Development]]></institution_en><team_members_id>28659</team_members_id><team_members_names><![CDATA[ Doktorand: Beti Zaharija ]]></team_members_names><keywords_hr><![CDATA[Shizofrenija, Mentalna bolest, Agregiranje proteina, Drosophila, Neuroznanost]]></keywords_hr><keywords_en><![CDATA[Schizophrenia, Mental illness, Protein Aggregation, Drosophila, Neuroscience]]></keywords_en><summary_hr><![CDATA[Schizofrenija, bipolarni poremećaj i teška depresija su devastirajuće mentalne bolesti s jako kompliciranom genetskom pozadinom. U cilju izbjegavanja složenosti genetike, predlažemo istraživanje izravno na proteinima uključenim u staničnu patologiju. Inspiraciju smo dobili zahvaljujući spoznajama neurodegenerativnih bolesti, kao što su Alzheimerova i Parkinsonova bolest, u kojima specifični proteini formiraju netopive krivo smotane agregate u mozgu. Radna hipoteza je da poremećena proteostaza može također biti razlog kroničnim mentalnim bolestima. Rezultati istraživanja upućuju na pet proteina koji potencijalno formiraju netopive agregate u mozgu dijela pacijenata s teškim mentalnim bolestima. To su: CRMP1. DISC1, dysbindin-1, NPAS3 and TRIOBP-1. Do danas nije poznato da li ovi proteini agregiraju zajedno ili imaju kumulativni efekt u istom pacijentu.Predloženi projekt ima za cilj integrativni pristup istraživanju agregacije ovih pet proteina. Biti će određena regija neophodna za agregaciju i iskorištena za sintezu mutiranih formi koje imaju ili nemaju sposobnost stvaranja agregata. Potom će divlji tip i mutant protein biti analizirani u cilju određivanja posljedice agregacije, bilo zasebno ili u kombinaciji. Istraživat će se na neuronima sličnim staničnim kulturama da se odrede posljedice agregata na razvoj, i također na transgenoj vinskoj mušici - Drosophila u cilju testiranja utjecaja na ponašanje.Eksperimente koje predlažemo, u budućnosti mogu poslužiti za analizu proteinskih agregata mentalnih bolesti u kompleksnijim trensgenim modelima. Također će omogućiti važne spoznaje o mogućoj uporabi agregata kao dijagnostičkih biomarkera i meta budućim terapeutskim intervencijama.]]></summary_hr><summary_en><![CDATA[Schizophrenia, bipolar disorder and major depression are devastating mental illnesses with a highly complicated genetic background. In order to circumvent this, we have proposed studying directly proteins involved in their cellular pathology. Specifically, we have taken inspiration from neurodegenerative conditions, such as Alzheimer&#39;s disease or Parkinson&#39;s disease, in which specific proteins form insoluble misfolded aggregates in the brain. We therefore hypothesised that disrupted proteostasis may also be a component of chronic mental illness. Data now exists implicating five proteins as potentially forming insoluble aggregates in the brains of subsets of patients with major mental illness: CRMP1, DISC1, dysbindin-1, NPAS3 and TRIOBP-1. To date however, it is not clear whether these proteins aggregate together or have cumulative effects on the same patients.The project proposed here therefore aims to take an integrative approach to studying the aggregation of these five proteins. The regions of these proteins required for aggregation will be determined and used to design mutant forms of them which either have or lack the ability to form aggregates. These wild-type and mutant proteins will then be investigated, in order to determine the consequences of aggregation of the proteins, both individually and in combination. This will be performed both in neuronal-like cell culture systems, in order to determine the consequences of aggregation on development, and also in transgenic Drosophila fruit flies in order to test their effects on behaviour.The experiments proposed here will aid in the design of more complex transgenic models of proteins aggregation in mental illness. They will also provide important insight into the potential value of such aggregates both as diagnostic biomarkers and as targets for future therapeutic interventions.]]></summary_en></project><project>
<id>7964</id><title_hr><![CDATA[EKONOMSKI SENTIMENT: STATISTIČKI, POLITIČKI, BIHEVIORALNI I MEDIJSKI ASPEKTI NJEGOVOG UTJECAJA NA EKONOMSKU AKTIVNOST]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4385</user_id><user_firstLast_name>Petar Sorić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-1038</code><acronim><![CDATA[EconSent]]></acronim><duration>02.05.2019 - 02.05.2023</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, </scie_field_hr><scie_field_en>Economy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Ekonomski fakultet u Zagrebu]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Economics and Business]]></institution_en><team_members_id>26644</team_members_id><team_members_names><![CDATA[ Doktorand: Marija  Logarušić ]]></team_members_names><keywords_hr><![CDATA[ankete pouzdanja poduzeća i potrošača, bihevioralna ekonomija, indeks neizvjesnosti ekonomske politike, strojno učenje, analiza medijskih sadržaja]]></keywords_hr><keywords_en><![CDATA[Business and Consumer Surveys, Behavioral Economics, Economic Policy Uncertainty Index, Machine Learning, Media Content Analysis]]></keywords_en><summary_hr><![CDATA[Svjetska financijska kriza jasno je pokazala da ekonomski modeli ne mogu adekvatno objasniti ni prognozirati događaje poput gospodarskog pada 2008.g. Ekonomisti su na to odgovorili uvođenjem latentnih varijabli poput sentimenta u svoje analize. Ključnu ulogu u tim nastojanjima imale su ankete pouzdanja poduzeća i potrošača, bogate baze podataka o medijskim izvještajima te razna ispitivanja političkog sentimenta.Ciljevi ovog projekta (proizašli iz neophodne multidisciplinarnosti ekonomskog istraživanja) su:1) Identificirati uzročne veze između ekonomskog sentimenta, medijskih sadržaja, rezultata anketa o političkim preferencijama i ekonomske aktivnosti2) Testirati perzistentnost političkog i ekonomskog sentimenta među EU zemljama i po gospodarskim sektorima3) Analizirati stupanj sinkronizacije ciklusa ekonomskog sentimenta između perifernih zemalja i jezgre EU4) Testirati hipotezu „nove umjerenosti“ nakon krize 2008. na političkom i ekonomskom sentimentu u pojedinim članicama EU 5) Razviti indeks iznenađenja temeljenog na BCS podacima i primijeniti ga u kratkoročnom prognoziranju ekonomske aktivnosti u pojedinim članicama EU6) Generirati ekonomske indikatore temeljene na anketnim podacima o očekivanjima pomoću evolucijskog programiranja7) Modificirati metodologiju indeksa neizvjesnosti ekonomske politike korištenjem tehnika strojnog učenja u svrhu osnaživanja njegovih vodećih karakteristika (primjena na SAD i Hrvatsku)Ovaj projekt trebao bi doprinijeti podizanju svijesti ekonomista o nužnosti koherentnog multidisciplinarnog pristupa analizi makroekonomskih fenomena. Korištenje anketa o političkom mnijenju i podataka iz medijskih izvještaja može pripomoći našem razumijevanju kompleksnosti ekonomskih procesa, kao i njihove međupovezanosti s društvenim kretanjima (politikom i medijima). Također, očekuje se da će prodiranje metoda strojnog učenja u ekonomiju u cijelosti unaprijediti kvalitetu prognoziranja standardnih vodećih ekonomskih pokazatelja.]]></summary_hr><summary_en><![CDATA[The global financial crisis has vividly demonstrated that economic models are not able to adequately explain (or forecast) extreme events such as the economic downfall in 2008. Economists have responded by introducing latent variables (such as economic agents’ sentiment) in their analyses. The pivotal role in these efforts has been assigned to Business and Consumer Surveys (BCS), rich news media datasets, and various political opinion polls.The goals of this project (stemming from the much-needed multidisciplinarity of economic research) are to:1)	Identify causal links between economic sentiment, news media contents, political opinion poll results and economic activity2)	Test the persistence of political and economic sentiment across EU countries and economic sectors3)	Analyze the synchronization degree of economic sentiment cycles between peripheral and core EU countries 4)	Test the “new modesty” hypothesis after the 2008 crisis on political and economic sentiment in EU Member States 5)	Develop a BCS-based surprise index and apply it in short-term forecasting of economic activity in individual EU Member States6)	Generate data-driven economic indicators from survey expectations by means of evolutionary computation7)	Modify the methodology of Economic Policy Uncertainty (EPU) Index by utilizing machine learning techniques in order to strengthen its leading characteristics (applications to USA and Croatia)This project should contribute to raising economists’ awareness of the necessity of a coherent multidisciplinary approach to assessing macroeconomic phenomena. Utilizing political opinion polls and news reports datasets might add to our understanding of the complexity of economic processes, as well as of their interrelationships with other social developments (politics and the media). Likewise, the penetration of machine learning into economics is expected to raise the overall forecasting quality of standard economic leading indicators.]]></summary_en></project><project>
<id>7965</id><title_hr><![CDATA[Utjecaj majčinog metaboličkog stanja na serotoninski sustav posteljice i neonatusa: od metilacije DNA do funkcije proteina]]></title_hr><title_en><![CDATA[]]></title_en><user_id>519</user_id><user_firstLast_name>Jasminka Štefulj</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-7794</code><acronim><![CDATA[PLANS]]></acronim><duration>13.05.2019 - 01.12.2024</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>28681</team_members_id><team_members_names><![CDATA[ Doktorand: Maja Perić ]]></team_members_names><keywords_hr><![CDATA[serotonin, posteljica, krv iz pupkovine, metilacija DNA, gestacijski dijabetes]]></keywords_hr><keywords_en><![CDATA[serotonin, placenta, cord blood, DNA methylation, gestational diabetes]]></keywords_en><summary_hr><![CDATA[Serotonin (5HT) je multifunkcionalna signalna molekula, najpoznatija kao neurotransmiter središnjeg živčanog sustava. Osim toga, 5HT igra važne ekstracerebralne uloge, kako u odrasloj dobi tako i tijekom razvoja. Poremećaji 5HT homeostaze povezuju se s mnogim mentalnim zdravstvenim problemima, a pojavljuju se i kao važan čimbenik u pretilosti i dijabetesu. Sve više dokaza sugerira da metilacija DNA modulira ekspresiju 5HT-regulirajućih gena i da može doprinositi  serotoninskoj disfunkciji. Metilacija DNA je dinamičan proces osjetljiv na okolinske utjecaje, posebno tijekom ranog razvoja. Naši nedavni rezultati upućuju da je posteljična metilacija DNA gena za 5HT prijenosnik (SLC6A4), glavni regulator 5HT signalizacije, osjetljiva na majčine metaboličke nepravilnosti povezane s gestacijskim dijabetes melitusom (GDM). Ovaj projekt usmjeren je na daljnje razumijevanje utjecaja majčinog metaboličkog stanja u trudnoći na 5HT sustav posteljice i novorođenčeta. Korištenjem tkiva posteljice i primarnih stanice posteljice dobivenih iz klinički dobro definiranih zdravih i GDM trudnoća, istražit ćemo odnos majčine gestacijske glikemije i predgestacijskog indeksa tjelesne mase (pITM) s posteljičnom metilacijom i ekspresijom gena SLC6A4 i gena za 5HT receptor tipa 2A (HTR2A). Nadalje, studijama in vitro na humanim primarnim trofoblastima istražit ćemo kako izloženost glukozi utječe na metilaciju DNA i ekspresiju gena SLC6A4 te na funkciju odgovarajućeg genskog produkta (aktivnost unosa serotonina). Konačno, istražit ćemo odnos majčine glikemije i pITM s 5HT sustavom novorođenčeta, mjerenjem serotoninskih biokemijskih parametara (razina 5HT, aktivnost 5HT prijenosnika, agregacija trombocita) i metilacije DNA 5HT-regulirajućih gena u krvi iz pupkovine.]]></summary_hr><summary_en><![CDATA[Serotonin (5HT) is a multifunctional signaling molecule, the best known as the central nervous system neurotransmitter. In addition, 5HT plays important extra-cerebral roles, both in adulthood and during development. Disturbances in 5HT homeostasis have been linked to many mental health conditions and are emerging as an important contributor also to obesity and diabetes. Rising evidence suggests that DNA methylation modulates expression of 5HT-regulating genes and may contribute to 5HT dysfunction. DNA methylation is a dynamic process sensitive to environmental influences, particularly during early development. Our recent results suggest that placental DNA methylation of the 5HT transporter gene (SLC6A4), a principal regulator of 5HT signaling, is sensitive to maternal metabolic derangements associated with gestational diabetes mellitus (GDM). This project is aimed to further understand impact of maternal metabolic state in pregnancy on placental and newborn&#39;s 5HT system. Using placental tissue and  primary placental cells obtained from clinically well-defined healthy and GDM pregnancies, we will investigate relationship of maternal gestational glycaemia and pregestational body mass index (pBMI) with placental DNA methylation and expression of SLC6A4 and 5HT receptor type 2A (HTR2A) genes. In addition, by in vitro studies in human primary trophoblasts, we will investigate how exposure to glucose affects SLC6A4 DNA methylation and expression as well as function of the corresponding gene product (serotonin uptake activity). Finally, we will investigate relathionship of meternal glycemia and pBMI with newborn&#39;s 5HT system, by measuring 5HT-related biochemical parameters (5HT levels, platelet 5HT uptake, platelet aggregation) and DNA methylation of 5HT-regulating genes in umbilical cord blood.]]></summary_en></project><project>
<id>7966</id><title_hr><![CDATA[Razumijevanje rimskih granica: primjer istočnog Jadrana]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4028</user_id><user_firstLast_name>Mirjana Sanader</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-3004</code><acronim><![CDATA[AdriaRom]]></acronim><duration>08.03.2019 - 07.09.2023</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Arheologija, </scie_field_hr><scie_field_en>Archeology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>25773</team_members_id><team_members_names><![CDATA[ Doktorand: Domagoj Bužanić ]]></team_members_names><keywords_hr><![CDATA[Istočni Jadran, Rimljani, pogranična zona, delmatski limes, rimski logori i kasteli, rimska vojska, nedestruktivne arheološke metode]]></keywords_hr><keywords_en><![CDATA[Eastern Adriatic, Romans, border zone, Delmataean limes, legionary fortresses, auxiliary forts, Roman army, non-destructive archaeology]]></keywords_en><summary_hr><![CDATA[Nakon uspjeha u Prvom punskom ratu, Rimljani su se zainteresirali za područje Grčke i Makedonije te su stoga počeli tražiti odgovarajuće prometne pravce prema tim teritorijima. Uz morski, jedini kopneni put vodio je duž istočne jadranske obale nastanjene narodima koje su Rimljani nazivali Ilirima. Rimsko osvajanje tog područja trajalo je od Prvog ilirskog rata 229. god. pr. Kr. do 9. god. po. Kr. Kako bi osigurali osvojeni teritorij između kolonija Jadera i Salone, gdje su se već smjestili prvi rimski imigranti, Rimljani su sagradili dva legijska logora i nekoliko kastela. U znanstvenoj literaturi taj je obrambeni sustav lakonski nazivan Delmatski limes, što je uzrokovalo trajnu znanstvenu raspravu. Međutim, zbog nedostatka arheoloških istraživanja koja bi podržala raspravu, još treba dovršiti sveobuhvatni pregled konteksta i značenja gore spomenute izgradnje. Namjera AdriaRom projekta jest istraživanje linije logora i kastela na tzv. Delmatskom limesu kako bi se pokazalo je li ta linija bila granica ili ne. Slijedom toga projekt bi pokušao pokazati koliku je ulogu ta granica imala u zaštiti rimskih imigranata i njihovih ekonomskih interesa. Pritom će projekt AdriaRom koristiti metodološki pristup temeljen na kombinaciji triju metoda: primjeni nedestruktivnih arheoloških istraživanja, ciljanih arheoloških iskopavanja i analizi arheoloških nalaza. Naime, ako su navedene građevne konstrukcije uistinu bile u funkciji obrane pogranične zone, to bi impliciralo da je tzv. Delmatski lime bio jedan od najranijih rimskodobnih obrambenih sustava.Ishodi predloženog projekta AdriaRom omogućit će bolje razumijevanje i potaknuti daljnje rasprave o razvoju rimskih granica, sigurnosnim i imigracijskim politikama u pograničnim zonama duž istočne obale Jadrana, kao i u rimskom svijetu općenito.]]></summary_hr><summary_en><![CDATA[Following their success in the First Punic War, the Romans became more interested in the area of Greece and Macedonia and hence sought appropriate routes to those territories. The only alternative to traveling there by the sea was using the overland route leading along the eastern Adriatic coast inhabited by the people referred to by Romans as Illyrians. The Roman conquest of this region lasted from the First Illyrian war in 229BCE until 9CE. To secure the conquered territory between the colonies of Iader and Salona, where the first Roman immigrants had already arrived, Romans built two fortresses and several forts. In the scientific literature, this defence construction was laconically called the Delmataean limes, and it has been the subject of persistent scientific discussion. However, due to insufficient archaeological research that would support the discussion, comprehensive overview of the context and meaning of above mentioned construction is yet to be completed.The aim of the AdriaRom project is to investigate the line of fortresses and forts of so called Delmataean limes in order to show whether that line was a border or not. Consequently, project aims to establish the role of the border in the protection of the safety and economic interests of Roman immigrants. In doing so, the AdriaRom project will use a methodological approach based on the combination of three methods: application of non-destructive archaeological research, targeted archaeological excavations and analysis of archaeological findings. Namely, if the stated construction was indeed intended to be a border line of a frontier zone, it would imply that so called Delmataean limes was one of the earliest Roman defence systems.The outcome of the proposed AdriaRom project will enable better understanding and drive further discussions about the development of Roman borders, security and immigration policies in frontier zones along the eastern Adriatic coast, as well as in the rest of the Roman world.]]></summary_en></project><project>
<id>7968</id><title_hr><![CDATA[INOVATIVNI FUNKCIONALNI PROIZVODI OD JANJEĆEG MESA]]></title_hr><title_en><![CDATA[]]></title_en><user_id>313</user_id><user_firstLast_name>Maja Popović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-1737</code><acronim><![CDATA[INOJANJETINA]]></acronim><duration>25.03.2019 - 24.09.2023</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Veterinarska medicina, </scie_field_hr><scie_field_en>Veterinary medicine, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Veterinarski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Veterinary Medicine]]></institution_en><team_members_id>28633</team_members_id><team_members_names><![CDATA[ Doktorand: Luka Pajurin ]]></team_members_names><keywords_hr><![CDATA[plemenita pečurka, janje, nutritivna modulacija, funkcionalni proizvod, tehnologija mesa]]></keywords_hr><keywords_en><![CDATA[white button muschroom, lamb, nutrition modulation, functional produc, meat technologyi]]></keywords_en><summary_hr><![CDATA[Janjeće meso se odlikuje vrlo plemenitim okusom i mirisom te se navodi kao izvor biološki vrijednih proteina, vitamina B kompleksa i nekih minerala, lako je probavljivo te je izvanrednih dijetetskih osobina no meso ima relativno visok udio masti (7,8 g/100 g krtog mesa) i kolesterola (78 mg/100g krtog mesa).U ovom projektu naše prethodno znanstveno dokazane preporuke o sigurnom i djelotvornom uvođenju pripravka plemenite pečurke (PPP) u hranu za perad i svinje ispitati ćemo na modelu janjeta (što do sada nije poznato), te pri tome istovremeno predstaviti mogući tržišno novi proizvod (janjetine s nižim udjelima masti i kolesterola). U dosadašnjim istraživanjima zapazili smo snižavanje koncentracije kolesterola i glukoze u serumu ispitivanih ovaca hranjenih uz dodatak PPP no da li je isti učinak i na meso nije poznato. S obzirom na navedeno, cilj je ovoga projekta ocijeniti utjecaj dodatka PPP na kvalitetu mesa janjadi koje bi onda bilo pogodno kao sirovina za  proizvodnju funkcionalnih proizvoda koji se temelje na inovativnim rješenjima u tehnološkim postupcima proizvodnje.]]></summary_hr><summary_en><![CDATA[Lamb meat is characterized by a very noble taste and smell, and is cited as a source of biologically valuable proteins, vitamins of B complex and some minerals, easily digestible and with exceptional nutritional qualities. but the meat has a relatively high fat content (7.8 g/100 g lean meat) and cholesterol (78 mg/100g of lean meat). In this project our previous recommendations on scientifically proven safe and effective introduction of white button mushrooms (WBM) preparation in feed for poultry and pigs will be tested on the lamb model (which was not known until now). At the same time a possible new product on a market - lamb with lower fat and cholesterol levels, would be presented. That is because we have in our previous studies observed a reduction in plasma cholesterol and glucose levels of tested sheep fed with the addition of WBM preparation but whether the same effect is in the meat is not known. That being said, the goal of this project is to evaluate the influence of WHB feed supplementation on lambs meat quality which would then be suitable as a material for production of functional products based on innovative solutions in technological processes of production.]]></summary_en></project><project>
<id>7969</id><title_hr><![CDATA[Kvantificiranje neodređenosti u formalizmu nuklearnih energijskih funkcionala gustoće ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>780</user_id><user_firstLast_name>Tamara Nikšić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-6359</code><acronim><![CDATA[NucEDF]]></acronim><duration>20.02.2019 - 19.02.2023</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>25816</team_members_id><team_members_names><![CDATA[ Doktorand: Giacomo Accorto ]]></team_members_names><keywords_hr><![CDATA[Nuklearni energijski funkcionali gustoće, strukutra atomske jezgre, kolektivni modeli, fisija, Bayesian analiza]]></keywords_hr><keywords_en><![CDATA[Nuclear energy density functionals, structure of atomic nucleus, collective models, fission, Bayesian analysis]]></keywords_en><summary_hr><![CDATA[Opći cilj projekta NucEDF je razvoj i primjena inovativnog nuklearnog energijskog funkcionala gustoće koji bi osigurao precizna i pouzdana predviđanja svojstava osnovnog stanja i kolektivnih pobuđenja pokrivajući pritom cijelu kartu nuklida.Tijekom projekta ćemo formulirati i implementirati teorijski formalizam ne-empirijskih funkcionala kroz sljedeće specifične ciljeve: i) razvoj sljedeće generacije nuklearnih energijskih funkcionala gustoće zasnovanih na relativističkim nukleon-nukleon interakcijama izvedenim pomoću kovarijantne kiralne efektivne teorije polja, ii) razvoj sveobuhvatne baze podataka sa svojstvima osnovnog stanja i kolektivnih pobuđenja atomskih jezgri, iii) procjena primjenjivosti tehnika funkcionalne renormalizacijske grupe u razvoju nuklearnih energijskih funkcionala gustoće, iv) primjena Bayes-ovih metoda u analizi teorijskih neodređenosti raznih opservabli, v) unapređenje opisa procesa inducirane fisije, vi) unapređenje opisa procesa spontane fisije. Koristeći statističke metode i tehnike naprednog računarstva procijenit ćemo stabilnost i međusobne korelacije parametara nuklearnog energijskog funkcionala gustoće, izračunati neodređenost parametara i posljedičnu neodređenost izračunatih opservabli te ih uključiti u bazu podataka nuklearnih svojstava. Istražit ćemo utjecaj različitih stupnjeva slobode na proces fisije i izračunati distribucije fisionih fragmenata. Očekujemo da će projekt NucEDF pozitivno utjecati ne samo na zajednicu teorijskih nuklearnih fizičara, nego i na eksperimentalne nuklearne fizičare pružajući podršku postojećim i planiranim eksperimentalnim programima. Planirane aktivnosti će također ojačati kapacitete NucEDF projektnog tima u području naprednog računarstva.]]></summary_hr><summary_en><![CDATA[The project NucEDF will develop and apply novel nuclear energy density functional (EDF) capable to provide accurate and reliable predictions for the nuclear ground state properties and collective excitations over the entire nuclear chart. We will formulate and implement a framework for the non-empirical nuclear EDFs  with specific objectives: i) to develop the next generation  nuclear EDF  based on relativistic nucleon-nucleon interactions derived using covariant chiral effective field theory, ii) to develop comprehensive database containing nuclear ground state properties and collective excitations over the entire nuclear chart, iii) to assess the applicability of the functional renormalization group techniques in constructing the nuclear EDF, iv) to apply the Bayesian inference methods in an analysis of theoretical statistical uncertainties for various observables calculated with the newly developed EDF, v) to improve the description of the induced fission process within the EDF framework, vi) to improve the description of the spontaneous fission process within the EDF framework. Using statistical methods and advanced computing techniques, the stability and interdependence of the EDF parameters, the inherent parameter uncertainties and their propagation, and the corresponding uncertainties of predicted observables will be calculated and included in the developed database. Influence of various degrees of freedom on the fission process will be studied and the resulting distributions for the fission fragment yields will be calculated. The expected impact of the NucEDF project will influence not only the theoretical, but also the experimental nuclear physics community by providing support for the existing and planned experimental programmes. The planned activities will also strengthen the capacities of the NucEDF project team in the area of high-performance computing.  ]]></summary_en></project><project>
<id>7970</id><title_hr><![CDATA[Novi spojevi temeljeni na bioizosterima purina za ispitivanje njihovih antitumorskih i antipatogenih djelovanja]]></title_hr><title_en><![CDATA[]]></title_en><user_id>76</user_id><user_firstLast_name>Silvana Raić-Malić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-4840</code><acronim><![CDATA[PurBioCaPa]]></acronim><duration>18.02.2019 - 15.12.2025</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet kemijskog inženjerstva i tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Chemical Engineering and Technology]]></institution_en><team_members_id>28746</team_members_id><team_members_names><![CDATA[ Doktorand: Valentina Rep ]]></team_members_names><keywords_hr><![CDATA[purinski bioizosteri, benzimidazol, benzotiazol, 1,2,3-triazol, antitumorska, antibakterijska, antitripanosomska aktivnost]]></keywords_hr><keywords_en><![CDATA[purine bioisosteres, benzimidazole, benzothiazole, 1,2,3-triazole, anticancer, antibacterial, antitrypanosomal activity]]></keywords_en><summary_hr><![CDATA[S ciljem razvoja novih kemijskih entiteta sa snažnim i selektivnim antitumorskim, antibakterijskim i antitripanosomskim učinkom, predlažemo dizajniranje i sintezu novih purinomimetika primjenom strategije dizajniranja lijekova, poput bioizosterije i izmjene skeleta kod kojih se atomi dušika u aromatskom prstenu zamjenjuju atomom ugljika ili drugim heteroatomom. Derivati strukturno srodni purinima povezat će se s drugom farmakofornom jedinicom preko različitih premosnica kako bi se odredio njihov utjecaj na interakciju s molekulskom metom, a time i na biološku aktivnost. Radi ispitivanja moguće prednosti održivih sintetskih metoda u odnosu na tradicionalni pristup, uz klasične će se sintetske metode izabranih reakcija provesti i nekonvencionalne, poput mehanokemijskih i protočnih reakcija provedenih u mikroreaktoru. Kako bi se ostvario cilj predloženog projekta, nužno je koordinirano provođenje sinteze i optimiranje struktura, zajedno s metodama dizajniranja spojeva i ispitivanja njihovih bioloških djelovanja. Potom će se provesti antipatogena i citostatska ispitivanja s posebnim naglaskom na dodatna ispitivanja novopripravljenih spojeva na izabrane kemorezistentne tumorske stanične linije i bakterijske kliničke sojeve koji su rezistentni na postojeće antibiotike. Nadalje, za najdjelotvornije spojeve provest će se istraživanja molekulskog mehanizma djelovanja usmjerena na polinukleotide (DNA/RNA), odnosno enzime odabrane analizom in silico. Na temelju rezultata bioloških ispitivanja, ciljanim će se strukturnim modifikacijama optimirati strukture odabranih spojeva kandidata u svrhu poboljšanja njihove biološke aktivnosti i ADMET svojstava. Očekujemo da će u konačnici projekt rezultirati novim predvodnim spojevima sa selektivnim i učinkovitim antipatogenim, odnosno citostatskim djelovanjem, koji neće biti toksični, i koji će zadovoljiti potrebne kriterije za sljedeću fazu optimiranja predvodnog spoja.]]></summary_hr><summary_en><![CDATA[With the aim to develop new chemical entities with marked and selective anticancer, antibacterial and antitrypanosomal activity, we propose the design and synthesis of novel purinomimetics using the bioisosterism and scaffold hop by swapping nitrogen atoms with carbon and other heteroatoms in an aromatic ring. Purine-related derivatives will be linked to another pharmacophoric unit through various linkers to assess their impact on molecular target interaction and thereby biological activity. To evaluate the benefit of sustainable synthetic method to traditional approach, batch-based syntheses of chosen reactions will be translated to non-conventional, such as mechanochemical and micro-flow processes. In order to accomplish the aim of the proposed project, the synthesis and structure optimization along with drug design tools and biological evaluations will be performed in a coordinated manner. Furthermore, antipathogenic and cytostatic evaluations of newly prepared compounds will be performed emphasizing the additional assays on selected chemoresistant cancer cell line and antibiotic-resistant bacteria clinical strains. The molecular mechanism studies of the most effective compounds targeting polynucleotides (DNA/RNA) or enzymes, indicated by in silico analysis, will be subsequently carried out. On the basis of results of biological evaluations, structure optimization by chemical modification of selected compound candidates will be performed to improve their biological potency and ADMET properties. Finally, we expect that new lead compounds with selective and pronounced antipathogenic and/or cytostatic activities with no toxicity will be identified and satisfy necessary criteria for further lead optimization phase. ]]></summary_en></project><project>
<id>7971</id><title_hr><![CDATA[Višestruki stresori u vodenom okolišu - razumijevanje svojstava stresora i receptora]]></title_hr><title_en><![CDATA[]]></title_en><user_id>12890</user_id><user_firstLast_name>Marko Rožman</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-7618</code><acronim><![CDATA[]]></acronim><duration>09.05.2019 - 09.10.2023</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Interdisciplinarne prirodne znanosti, </scie_field_hr><scie_field_en>Interdisciplinary natural sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>27426</team_members_id><team_members_names><![CDATA[ Doktorand: Ivana Grgić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>7976</id><title_hr><![CDATA[Nove primjene 14 MeV neutrona]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1377</user_id><user_firstLast_name>Davorin Sudac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-5687</code><acronim><![CDATA[NeA]]></acronim><duration>19.02.2019 - 26.12.2026</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>28636</team_members_id><team_members_names><![CDATA[ Doktorand: Martina Pavlovic Pavlovic ]]></team_members_names><keywords_hr><![CDATA[neutroni,istraživanje nafte, metan hidrat, rijetke zemlje, standardni materijali, metode detekcije, nove analitičke metode]]></keywords_hr><keywords_en><![CDATA[neutrons, oil logging, methane hydrate, rare earth elements, standard materials, method of detection, new analytical methods]]></keywords_en><summary_hr><![CDATA[Razvit će se metoda primjene brzih pulsiranih neutrona i/ili metode pridružene alfa čestice u istraživanju nalazišta metan hidrata (MH) i elemenata rijetkih zemalja (ERZ). Nalazišta metan hidrata mogu poslužiti kao izvor energije jednako značajan kao i postojeći fosilni izvori energije. Razvit će se metoda pasivnog određivanja koncentracija ERZa pomoću radioaktivnog izotopa 176Lu. Razviti će se kalibracijski postupak za neutronske senzore koji mjere C/O, N/C omjere kao i omjere drugih elemenata od interesa (Al, Si, P, S, Cl, Fe, …). Kako koncentracije elemenata mjerena neutronskim senzorom ovise o okruženju, kalibracijski postupak će se ponoviti za različita tipična okruženja (mineralna, metalna ili organska matrica). Specijalna pažnja posvetiti će se razvoju nove instrumentacije u istraživanju naftnih bušotina (Carbon-to Oxygen oil logging). Cilj istraživanja je razviti metodologiju mjerenja varijacija omjera koncentracija kemijskih elemenata, naročito C/O omjera na maloj skali, što može značajno povećati efikasnost eksploatacije već postojećih naftnih bušotina. Ciljevi istraživanja su:-	Razvoj metoda za ispitivanje podvodnih MH, ERZ i drugih mineralnih nalazišta od interesa-	Razvoj naprednih nuklearnih senzora, naročito za monitoriranje sirove nafte, precizno mjerenja C/O omjera u naftnim bušotinama, uz pomoć najnovijih tehnologija-	Razvoj ‘’ Quality Assurance/Quality Control QA/QC’’ procedure za neutronske sisteme-	Izobrazba mladih istraživača]]></summary_hr><summary_en><![CDATA[Applications of nuclear analytical methods in exploring and monitoring of methane hydrate (MH) and rare earth elements (REE) deposits will be developed by using the pulsed fast neutrons and/or associated alpha particle imaging (API) technique. Methane hydrate deposits can serve as an energy source favorably to the all of the world remaining conventional hydrocarbon sources. A method of passive determination of the REE concentration using a radioactive isotope 176Lu will be developed. The calibration procedures for neutron interrogation systems will be developed for measuring the C/O, N/C ratios and ratios of the other elements of interest (Al, Si, P, S, Cl, Fe, …). Since the concentration values measured by neutron interrogation systems depend on surrounding material too, the calibration procedure will be repeated for different types of surrounding (mineral, metal or organic matrix). Special interest shall be assigned to development of a new instrumentation in Carbon-to-Oxygen (C/O) oil logging. The aim of this research would be the development of a methodology for the measurement of small scale variations in chemical elements concentrations, in particular of C/O ratio, which could significantly increase the exploitation of the existing oil wells.  The specific research objectives are: -	Development of methods for investigation of underwater MH, REE and other mineral deposits of interest;-	Development of advanced nuclear sensors, in particular for crude oil monitoring and for precise C/O logging for very thin layers, coupled with cutting-edge developments in neutron generators, detector technologies, “smart” collimators and analysis techniques.-	Development of the Quality Assurance/Quality Control QA/QC procedures for neutron interrogation systems; -	Hands on training of young researchers.]]></summary_en></project><project>
<id>7977</id><title_hr><![CDATA[Molekularni aspekti patogenih procesa u AHCY deficijenciji]]></title_hr><title_en><![CDATA[]]></title_en><user_id>54</user_id><user_firstLast_name>Oliver Vugrek</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-8192</code><acronim><![CDATA[MAPinAD]]></acronim><duration>05.06.2019 - 05.12.2023</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>28663</team_members_id><team_members_names><![CDATA[ Doktorand: Ivana Pavičić ]]></team_members_names><keywords_hr><![CDATA[Odgovor na oštećenje DNA, adenozin, stanični ciklus, karcinogeneza, bolest jetre, metastaza, transkriptomika]]></keywords_hr><keywords_en><![CDATA[DNA damage response, adenosine, cell cycle, cancerogenesis, liver disease, metastasis, transcriptomics]]></keywords_en><summary_hr><![CDATA[S-adenozilhomocistein hidrolaza (AHCY) katalizira hidrolizu S-adenozilhomocisteina (SAH) na adenozin (Ado) i homocistein (Hcs). Novija istraživanja ukazuju na povezanost AHCY i raka na nekoliko razina: AHCY može regulirati fenotipska obilježja stanica raka; AHCY kao ciljna molekula u terapijskim pristupima te kao biomarker za određena maligna oboljenja. Veza između adenozina (jednog od produkata hidrolize SAH) i raka jednim dijelom je poznata te uključuje stimulaciju proliferacije i ulogu u regulaciji upalnih/imunoloških procesa. Također, aktivnost AHCY u vezi je s razvojem patoloških promjena jetre, što potvrđuje i nedavno objavljen slučaj hepatocelularnog karcinoma kod pacijenta s nedostatnom aktivnošću AHCY.  Naši preliminarni podaci na stanicama hepatocelularnog karcinoma (HepG2) pokazuju da smanjena aktivnost AHCY uzrokuje sniženje razine Ado, uslijed čega dolazi do oštećenja DNA i zastoja u staničnom ciklusu. Iako navedeni podaci pokazuju ulogu AHCY u mehanizmima nastanka malignih oboljenja, točna molekularna podloga te veze nije razjašnjena. Da bismo je razjasnili, koristit ćemo &#39;multi-omics&#39; pristup, uz klasične metode kao što su analiza staničnog ciklusa, proliferacije i oštećenja DNA, na uzorcima tkiva i serumu pacijenata s patološkim promjenama jetre, odabranim staničnim linijama s utišanom ekspresijom AHCY, te na novorazvijenom transgeničnom mišu kao in vivo modelu.  Ispitat će se utjecaj sniženja razina adenozina (kao rezultat smanjene aktivnosti AHCY) na stanični metabolizam te predložiti mehanizam koji povezuje aktivnost AHCY, nastanak oštećenja DNA i regulaciju staničnog ciklusa. Rezultati predloženog istraživanja mogli bi unaprijediti terapijske pristupe u liječenju malignih oboljenja povezanih s smanjenom aktivnošću AHCY, te potaknuti razvoj novih metoda liječenja baziranih na regulaciji pomoću adenozina.]]></summary_hr><summary_en><![CDATA[S-adenosylhomocysteine hydrolase (AHCY) catalyzes the hydrolysis of S-adenosylhomocysteine (SAH) to Adenosine (Ado) and Homocysteine (Hyc). Recently, several studies pointed out connections of AHCY with cancer from various standpoints: as a player that possibly regulates cancer phenotype, as a druggable candidate, or, as a promising biomarker. Metabolome-wise, connections between adenosine and cancer have been established, showing stimulative effects on cell proliferation, and other important roles in inflammation or immunity. Implications of AHCY in hepatic pathology are well documented, and culminated in the recently reported case of hepatocellular carcinoma in an adult with AHCY deficiency. Also, as we have preliminary data showing that low AHCY activity and depletion of adenosine induces DNA damage and cell cycle arrest in hepatocellular carcinoma cells. In summary, involvement of AHCY in molecular mechanisms of cancer is undisputable. However, the molecular basis for the connection between AHCY and cancer is not quite obvious. In order to answers these questions we will deploy a multi-omics approach, in combination with basic molecular and cellular biology procedures focus on the role of AHCY and its mechanism of action on cell cycle, cellular proliferation and DNA damage response in histological and serum samples of liver disease patients, in relevant cancerous and AHCY deficient cell lines, and a unique mouse animal model. In particular, we will investigate the implications of adenosine, besides homocysteine, the primary product of AHCY hydrolytic activity on the cellular metabolism.  By answering these questions we hope to establish the mechanism that connects AHCY activity, DNA damage and regulation of cell cycle through adenosine levels. The outcomes of underlying research may lead to a refinement of therapeutical procedures for cancer as a result of AHCY malfunction, and a potentially new approach for targeted cancer therapy based on adenosine depletion. ]]></summary_en></project><project>
<id>7978</id><title_hr><![CDATA[Karakterizacija kandidat gena za kongenitalne anomalije bubrega i urotrakta (CAKUT) tijekom razvoja u miša i čovjeka]]></title_hr><title_en><![CDATA[]]></title_en><user_id>12479</user_id><user_firstLast_name>Katarina Vukojević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-1283</code><acronim><![CDATA[CAKUT]]></acronim><duration>01.06.2019 - 31.05.2023</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Split School of Medicine]]></institution_en><team_members_id>28630</team_members_id><team_members_names><![CDATA[ Doktorand: Mirela Lozić Lozić ]]></team_members_names><keywords_hr><![CDATA[kongenitalne anomalije bubrega i urotrakta, genetika, imunohistokemija, imunofluorescencija, knock-out miš]]></keywords_hr><keywords_en><![CDATA[congenital anomalies of the kidney and urinary tract, genetics, immunohistochemistry, immunofluorescence, knock-out mice]]></keywords_en><summary_hr><![CDATA[Kongenitalne anomalije bubrega i mokraćnog sustava (CAKUT) u 40-50% pedijatrijskih bolesnika dovode do krajnjeg stadija zatajenja bubrega. Među kategorijama CAKUTa, kongenitalna opstruktivna uropatija predstavlja zajednički i teški oblik malformacija. Zbog nedostatka temeljnog uvida o njegovoj primarnoj patogenezi, dijagnostičke i terapijske mogućnosti su ograničene.Nedavno smo identificirali dominantne štetne mutacije u DSTYK genu koji kodira dvostruku serin-treonin i tirozin protein-kinazu, kod osoba s malformacijama mokraćnog sustava koristeći sekvenciranje exoma u kombinaciji s funkcionalnim modelom u zebraste ribice (New Engl J Med 2013). Protein kodiran DSTYK genom djeluje kao pozitivan regulator u signalizaciji faktora rasta fibroblasta (FGF), tijekom nefrogeneze. Osim toga, identificirali smo pet novih gena kandidata za CAKUT koji su pokazali ekspresiju u miša i čovjeka tijekom razvoja urinarnog trakta. Među tim genima, DLG1 i KIF12 su vjerojatno susceptibilni geni za razvoj CAKUTa kod ljudi (Kidney Int 2015).Ovdje predlažemo početnu karakterizaciju funkcije novih gena kandidata za CAKUT tijekom embrionalnog razvoja, nefrogeneze i razvoja uretera. Prvo ćemo istraživati profil vremenskog-prostornog izražaja i ko-lokaliziranje kandidat gena za CAKUT u različitim fazama embriogeneze u tkivima normalnih miševa i ljudskog zametka te bubrega i mokraćnog sustava u razvoju i usporediti markere nefrogeneze i razvoja uretera. Zatim ćemo odabrati jedan visoko prioritetni novi kandidat gen te generirati i okarakterizirati miša koji nosi mutaciju u ovom genu od interesa (knockout miš), zatim ćemo identificirati mehanizme kojima mutacije u ovom genu dovode do malformacija urinarnog trakta kod ljudi.Ova studija je osmišljena kako bi se okarakterizirali funkcionalni učinci kandidat gena za CAKUT u razvoju mokraćnih puteva, identificirati disregulacijske putove i na kraju osmisliti nove dijagnostičke alate i terapijske strategije za taj učestali oblik zatajenja bubrega.]]></summary_hr><summary_en><![CDATA[Congenital Anomalies of the Kidney and the Urinary Tract (CAKUT) account for 40-50% of pediatric end-stage kidney failure. Among CAKUT categories, congenital obstructive uropathy represents a common and severe form. Due to paucity of fundamental insight about its primary pathogenesis, diagnostic and therapeutic options are severely limited.  We recently identified dominant deleterious mutations in DSTYK, encoding a dual serine-threonine and tyrosine protein-kinase, in individuals with urinary tract malformations using exome sequencing combined to functional modeling in zebrafish (New Engl J Med 2013). The protein encoded by DSTYK acts as a positive regulator of fibroblast growth factor (FGF) signaling during nephrogenesis. Additionally, we identified five novel candidate genes for CAKUT that showed specific expression in the human and mouse developing urinary tract. Among these genes, DLG1 and KIF12 are likely novel susceptibility genes for CAKUT in humans (Kidney Int 2015).Here we propose to initially characterize the function of novel CAKUT candidate genes during embryonic development, nephrogenesis and ureteric development. We will first study the candidate genes temporal-spatial expression and colocalization profile during different stages of embryogenesis in normal mouse and human embryonic tissue and in developing kidneys and urinary tract and compare to markers of nephrogenesis and ureteric development. We will next choose one high-priority novel candidate gene and generate and characterize mouse harboring mutation in a gene of interest (knockout mice) to identify the mechanisms by which mutations in this gene lead to urinary tract malformations in humans. This study is designed to characterize the functional effect of CAKUT candidate genes in urinary tract development, to identify dysregulated pathways, and, ultimately, to devise novel diagnostic tool and therapeutic strategies for this common form of renal failure.]]></summary_en></project><project>
<id>7980</id><title_hr><![CDATA[Predplanirana i reaktivna agilnost; razvoj i validacija specifičnih metoda mjerenja, utvrđivanje faktora utjecaja i učinkovitost transformacijskih postupaka]]></title_hr><title_en><![CDATA[]]></title_en><user_id>147</user_id><user_firstLast_name>Damir Sekulić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-1940</code><acronim><![CDATA[RAGCODS]]></acronim><duration>04.03.2019 - 04.03.2023</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Kineziologija, </scie_field_hr><scie_field_en>Kinesiology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Kineziološki fakultet]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Kinesiology]]></institution_en><team_members_id>27180</team_members_id><team_members_names><![CDATA[ Doktorand: Barbara Gilić ]]></team_members_names><keywords_hr><![CDATA[testovi, prediktori, povezanost, utjecaj, agilnost otvorene vještine, agilnost zatvorene vještine]]></keywords_hr><keywords_en><![CDATA[tests, predictors, associations, influence, open skill agility, closed skill agility]]></keywords_en><summary_hr><![CDATA[Poznata je važnost agilnosti u sportu, ali je u skorije vrijeme prepoznata njena važnost i izvan natjecateljskog sporta. Utvrđeno je postojanje dva manifestacijska oblika agilnosti: pred-planirane agilnosti (CODS) i reaktivne agilnosti (RAG). Ciljevi projekta su: (i) razviti testove za mjerenje RAG i CODS, (ii) utvrditi faktore utjecaja na RAG i CODS, (iii) provjeriti učinkovitost transformacijskih programa (treninga) u razvoju RAG i CODS; za sportaše i kliničku populaciju. Uzorak ispitanika činiti će sportaši i klinička populacija (svi stariji od 18 godina). Skupinu sportaša činiti će podskupine: rukometaši (n = 60; 50% žena), košarkaši (n = 60; 50% žena), vaterpolisti (n = 60; 50% žena) i igrači fustala (n = 60; 50% žena). Kliničku populaciju činiti će osobe starije od 50 godina koje će se nalaziti na postoperativnom tretmanu nakon operativnog zahvata zamjena zgloba ili artroskopske operacije koljena (n=100; 50% žena). Zavisne varijable biti će novokonstruirani testovi RAG i CODS. Nezavisne varijable biti će antropometrijske mjere i mjere sastava tijela (za sve skupine), mjere brzine, sile, eksplozivne snage i reaktivne snage (za sportaše). Najprije će se razviti i validirati testovi RAG i CODS temeljeni na bežičnim tehnologijama. Potom će se utvrditi povezanost nezavisnih i zavisnih varijabli. Konačno, provjeriti će se efikasnost specifičnih treninga u razvoju RAG i CODS. Metode obrade rezultata uključivati će procjenu metrijskih karakteristika testova, univarijatne i multivarijatne analize povezanosti nezavisnih i zavisnih varijabli, te analize za procjenu učinkovitosti treninga. Radit će se o jednom od prvih istraživanja u svijetu u kojem će se razviti testovi za mjerenje RAG i CODS u različitim sportovima, koje će sistematski istražiti problem RAG i CODS kod analizirane kliničke populacije, te koje će istražiti učinkovitost treninga RAG i CODS. Projekt će imati izravnu primjenu u sportskom treningu i postoperativnoj rehabilitacijskoj praksi.]]></summary_hr><summary_en><![CDATA[The importance of agility in sport is well known, and since recently the significance of this quality is recognized in non-athletic population. Two facets of agility are recognized, differentiating reactive agility (RAG), and change of direction speed (CODS). The aims of this project are: (i) to develop RAG and CODS tests, (ii) to identify predictors of RAG and CODS, (iii) to define efficacy of training aimed at development of RAG and CODS; in athletic- and non-athletic (clinical) participants. The sample will comprise athletes, and clinical sample. The athletes will be involved in handball (n = 60; 50% females), basketball (n = 60; 50% females), water polo (n = 60; 50% females), and futsal (n = 60; 50% females), Clinical sample will comprise 100 participants (50% females, > 50 years) patients at postoperative treatment after joint replacement or arthroscopic knee surgery. The developed tests of RAG and CODS will be observed as dependent variables (DV). The independent (IV) variables will comprise anthropometric/body composition indices (for all participants), sprinting-, power-, force-, and reactive-strength-capacites (for athletes). First, tests of RAG and CODS will be evaluated for reliability and validity. Next, relationships between IV and DV will be established. Finally, the efficacy of the training aimed at improvement of RAG and CODS will be evaluated. Statistics will include analyses aimed at evaluation of (i) reliability and validity of tests, (ii) relationships among variables, and (iii) evaluation of training effects. This investigation will be one of the first which will systematically develop and validate RAG and CODS tests in different sports and clinical population, and probably the first one where the problem of development of RAG and CODS will be systematically investigated. The findings will have direct implications in sports training, as well as in postoperative rehabilitation of an investigated clinical sample.  ]]></summary_en></project><project>
<id>7984</id><title_hr><![CDATA[Selektivno ciljanje matičnih stanica sarkoma askorbinskom kiselinom]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3273</user_id><user_firstLast_name>Inga Marijanović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-8407</code><acronim><![CDATA[ASTar]]></acronim><duration>07.06.2019 - 07.06.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>28662</team_members_id><team_members_names><![CDATA[ Doktorand: Maja Ledinski ]]></team_members_names><keywords_hr><![CDATA[sarkom, tumorske matične stanice, sarkosfere, askorbinska kiselina, čvrste lipidne nanočestice]]></keywords_hr><keywords_en><![CDATA[sarcoma, cancer stem cells, sarcospheres, ascorbic acid, solid lipid nanoparticles]]></keywords_en><summary_hr><![CDATA[Sarkomi su prilično smrtonosni oblici raka, ponajprije zbog kasne dijagnoze i uznapredovalosti pri pojavi simptoma. Zbog niske učestalosti i velikog broja podvrsta, sarkomi su zahtjevna bolest. Upravo stoga, potrebno je ciljati njihovu zajedničku osobinu, a to je postojanje matičnih stanica sarkoma. One predstavljaju mali udio u staničnoj populaciji tumora koje imaju sposobnost inicijacije tumora. Otporne su na terapije i zadržavaju sposobnost regeneracije tumora. Zbog specifičnosti matičnih stanica sarkome, za njihovo uništenje potrebno je ciljati molekularne različitosti. Matične stanice sarokoma se, kao i druge matične stanice, smatraju mirujućima te imaju karakterističan metabolički profil i redox stanje. Naši preliminarni rezultati ukazuju da askorbinska kiselina (AA) ima jak citotoksični učinak na matične stanice sarkoma dok ne utječe na vijabilnost drugih stanica. Stoga bi željeli pobliže istražiti utjecaj AA na matične stanice sarkoma analizirajući njene različite oblike – AA, dehidroksiaskorbinsku kiselinu (DHA) i askorbil palmitat (AP). Kako bi izbjegli ozbiljne nuspojave prilikom potencijalne kliničke primjene, ugradit ćemo AA, DHA i AP u čvrste lipidne nanočestice (SLN). Matične stanice sarkoma i primarne stanice sarkoma iz 30 pacijenata, mezenhimske matične stanice i stanične linije U2OS i HEK293 tretirat ćemo s AA, DHA i AP bez is a SLN. Odredit ćemo staničnu vijabilnost, vrstu stanične smrti i optimalno doziranje. Također ćemo analizirati profil onkogena i tumor supresora 30 sarkoma i istražiti mehanizme selektivnog ciljanja koristeći panele metabolizma i oksidativnog stresa. Ukoliko je osjetiljivost na AA specifična za matične stanice sarkoma, velika je vjerojatnost da je specifična i za matične stanice drugih tumora. Stoga bi ovi rezultati mogli imati velik klinički značaj jer bi se AA mogla koristiti kao adjuvantna terapija uz standardne lijekove s ciljem uništenja matične populacije stanica unutar tumora. ]]></summary_hr><summary_en><![CDATA[Sarcomas are quite deadly forms of cancer, primarily due to delayed diagnosis and advanced disease at presentation. The rarity of the disease combined with the diverse number of subtypes make sarcomas challenging. Therefore, it is important to target their common feature – the existence of sarcoma stem cells. They represent a small fraction of the cellular population of tumor that have the tumor-initiation capacity. They are resistant to current therapies retaining the capacity to regenerate tumor. Due to their specific properties, eradication of sarcoma stem cells requires targeting their molecular differences. Sarcoma stem cells, as other cancer stem cells, are generally considered quiescent with specific metabolic profile and redox state. Our preliminary data suggest that ascorbic acid (AA) has a strong cytotoxic effect on sarcoma stem cells while it does not interfere with viability of other cell types. Therefore, we would like to explore further the impact of AA on sarcoma stem cells by analyzing different its different forms – AA, dehydroascorbic acid (DHA) and ascorbic palmitate (AP). To avoid serious side effects in potential clinical application, we will incorporate AA, DHA and AP in solid lipid nanoparticles (SNPs). Sarcoma stem cells and primary sarcoma cells derived from 30 patients, mesenchymal stem cells, U2OS and HEK293 cell lines will be treated with AA, DHA and AP with and without SNP packaging. We will determine cell viability, cell death modality and dosage effect. Also, we will analyze oncogene/tumor suppressor profile from 30 sarcomas and explore mechanism of selective targeting using metabolic and oxidative stress panels. If sensitivity to AA is a property of sarcoma stem cells, there is a high probability that it is property of other cancer stem cells as well. Therefore, these data could have important and interesting clinical consequences as AA could be used as an adjuvant to standard therapy to eradicate tumor stem cell population.]]></summary_en></project><project>
<id>7986</id><title_hr><![CDATA[Adaptivno i prediktivno upravljanje utičnim hibridnim električnim vozilima]]></title_hr><title_en><![CDATA[]]></title_en><user_id>11149</user_id><user_firstLast_name>Joško Deur</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-3252</code><acronim><![CDATA[ACHIEVE]]></acronim><duration>01.12.2020 - 30.11.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, </scie_field_hr><scie_field_en>Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>24047</team_members_id><team_members_names><![CDATA[ Doktorand: Jure  Soldo ]]></team_members_names><keywords_hr><![CDATA[Utična hibridna električna vozila, modeliranje, sinteza voznih ciklusa, optimiranje, adaptivno upravljanje, prediktivno upravljanje, strojno učenje]]></keywords_hr><keywords_en><![CDATA[Plug-in hybrid electric vehicles, modelling, synthetic driving cycles, optimisation, adaptive control, predictive control, machine learning]]></keywords_en><summary_hr><![CDATA[Projekt se bavi projektiranjem adaptivnih i prediktivnih strategija upravljanja tokovima energije utičnih hibridnih električnih vozila (PHEV), kao ključne tranzicijske tehnologije prema energetski učinkovitom, čistom, tihom i održivom transportu budućnosti. Projekt je organiziran oko tri međusobno povezane istraživačke teme: (i) sinteza naturalističkih voznih ciklusa bazirana na metodi Markovljevih lanaca uzimajući u obzir promjenljiv nagib ceste i masu vozila; (ii) optimizirana strategija upravljanja tokovima energije PHEV-a koja za cilj ima postizanje minimalne potrošnje goriva te emisija štetnih plinova, dobre voznosti i udobnosti te umjerenog stupnja degradacije baterije, za širok spektar režima rada i voznih uvjeta; te (iii) adaptivne i stohastičke modelsko prediktivne strategije upravljanja zasnovane na estimaciji i predikciji statističkih značajki voznih ciklusa u stvarnom vremenu. Predložena metodologija demonstrira se kroz studiju slučaja vezanu uz gradske autobuse (PHEV naspram konvencionalnog/Diesel autobusa), za koju je projektnom timu na raspolaganju bogati skup snimljenih voznih ciklusa. Iako se istraživanje usredotočuje na PHEV u paralelnoj (P2) konfiguraciji i demonstrira na primjeru gradskih autobusa uključujući aspekte zona s niskim emisijama (LEZ), razvijena metodologija primjenjiva je i na druge tipove električnih vozila (HEV, EREV te BEV), konfiguracije (serijsku i serijsko-paralelnu) i kategorije (npr. osobna vozila i kamioni). Predložene strategije upravljanja sustavno se verificiraju u odnosu na referentno mjerilo postavljeno optimizacijama upravljačkih varijabli, pri čemu se kvantificiraju poboljšanja ostvarena primjenom adaptivnih i prediktivnih mehanizama te procjenjuje transferabilnost na druge konfiguracije PHEV pogona. Kako bi se ostvarili ambiciozni ciljevi istraživanja, projekt okuplja multidisciplinarnu istraživačku skupinu koja uključuje istraživače iz područja strojarstva, elektrotehnike i računarstva, te prometnih znanosti.]]></summary_hr><summary_en><![CDATA[The project deals with design of adaptive and predictive energy management control strategies for plug-in hybrid electric vehicles (PHEV), as a key transition technology towards an energy efficient, clean, quiet and sustainable transport of the future. The project is organised around three mutually interconnected research themes: (i) Markov chain-based synthesis of naturalistic driving cycles taking into account road grade and vehicle mass variability; (ii) optimised PHEV energy management control strategy providing minimal fuel consumption/emissions, favourable drivability and comfort, and modest battery degradation, for a wide range of operating modes and driving conditions; and (iii) adaptive and stochastic model predictive control strategies which account for on-line estimated and predicted statistical features of driving cycles. The proposed methodology is demonstrated through a case study of city buses (PHEV vs. conventional/Diesel bus), for which a rich set of recorded driving cycles is available to the project team. Although the research is focused on PHEVs of parallel (P2) configuration and city bus application including aspects of low-emission zones (LEZ), the developed methodology is applicable to other electric vehicle types (HEV, EREV, and also BEV), configurations (series and series-parallel) and categories (e.g. passenger vehicles and trucks). The proposed control strategies are systematically verified with respect to control trajectory optimisation benchmark provided, while quantifying improvements gained through adaptation and prediction mechanisms, and assessing transferability to other PHEV powertrain configurations. To accomplish the ambitious research goals, the project brings together an multidisciplinary research group including researchers from the areas of mechanical engineering, electrical engineering and computing, and traffic engineering.]]></summary_en></project><project>
<id>7987</id><title_hr><![CDATA[Moderne misleće žene: Intelektualni razvoj žena u Hrvatskoj 20. stoljeća]]></title_hr><title_en><![CDATA[]]></title_en><user_id>23254</user_id><user_firstLast_name>Andrea Feldman</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-4689</code><acronim><![CDATA[MMŽ/MWT]]></acronim><duration>01.05.2019 - 31.12.2023</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Povijest, </scie_field_hr><scie_field_en>History, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Učiteljski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Teacher Education]]></institution_en><team_members_id>23255</team_members_id><team_members_names><![CDATA[ Doktorand: Marijana Kardum ]]></team_members_names><keywords_hr><![CDATA[žene, intelektualna povijest, Hrvatska, kultura, obrazovanje, XX stoljeće ]]></keywords_hr><keywords_en><![CDATA[women, intellectual history, Croatia, culture, education, XX century]]></keywords_en><summary_hr><![CDATA[Projekt će se baviti konstrukcijom ženske intelektualne historije u Hrvatskoj, i identificirati idejne promjene u shvaćanju koncepta žene u 20. stoljeću kako bi se objasnila intelektualna ishodišta shvaćanja moderne žene. Pratit će se razvoj ideja koje su oblikovale prvenstveno žene vlastitim intelektualnim djelovanjem, utjecajem i kritikom mijenjajući tako društveni položaj žene i definiranjem kategorije intelektualca/ke. Istraživački fokus projekta smješten je u hrvatski te širi jugoslavenski i srednjeeuropski prostor od kraja 19. stoljeća do kraja 20. stoljeća. Razdoblje je to od pojave većeg sudjelovanja žena u društvenome i javnome životu s nakanom stjecanja potpune zakonske ravnopravnosti. Interdisciplinarno istraživanje obuhvatit će teorijske i prakseološke uvide iz historiografije, obrazovanja, teorije književnosti, antropologije, filozofije korištenjem domaće i strane literature i arhivske građe u nekoliko zemalja. Projekt će se baviti mehanizmima konstrukcije (nacionalnih, vjerskih, rodnih, klasnih, kulturnih) kolektivnih i individualnih identiteta ženske polovice stanovništva svih političkih uređenja na hrvatskom prostoru u vremenskom razdoblju od više od stoljeća. Ponudit će se kompleksnije razumijevanje utjecaja strukturnih promjena usred velikih društvenih, gospodarskih, kulturnih i političkih događaja promatranoga razdoblja. Projekt će istražiti osobe i ideje koje su kreirale promjene u razumijevanju (položaja) žene proučavanjem oblika i načina njihova društvenoga organiziranja i javnoga djelovanja (ženske organizacije, intelektualke: književnice, novinarke, učiteljice, profesorice, liječnice, umjetnice, znanstvenice, pripadnice društvene elite). Izrazita pozornost projekta usmjerena je neobjavljenoj i neistraženoj arhivskoj građi te nekonvencionalnim povijesnim izvorima javne i privatne provenijencije. ]]></summary_hr><summary_en><![CDATA[Project’s purpose is to construct intellectual history of women in Croatia and to detect ideological change in understanding of concept of woman in the first half of the 20th century. It will explain intellectual origins of modern woman in the context of changing social circumstances. It will trace development of ideas formulated by women in their intellectual endeavors, with their influence and criticism, changing their social position and defining the categories of intellectuals. The research is focused on Croat, Yugoslav and Central European space from the last decades of the 19th century to the end of the WWII. That period saw more active involvement of women in social and public life with an aim of achieving political and legal equality of women. The interdisciplinary research will encompass theoretical and practical insights in fields as diverse as history, education, literary theory, anthropology, philosophy.  International and domestic literature will be consulted, as well as archival sources in several countries. Project will reveal the mechanisms of construction of complex women&#39;s identities (both individual and collective) with reference to their national, religious, gender, class and cultural components. The aim is to understand life of women, during different political systems that reigned in this area through more than 50 years. Research will offer a complex understanding of structural changes that took place amidst great economic, social, cultural and political commotion. It will encompass personalities and ideas that created change in understanding of the status of women by study of the ways and forms of their social organizations and public actions (women&#39;s organizations, intellectuals, journalists, schoolteachers, professors, medical doctors, artists, scientists and members of society&#39;s elites). Focused on hitherto unpublished archival sources, the research will consult unconventional historical sources of public and private origins.]]></summary_en></project><project>
<id>7988</id><title_hr><![CDATA[Ekologija i karakterizacija dva nova virusa vinove loze]]></title_hr><title_en><![CDATA[]]></title_en><user_id>21451</user_id><user_firstLast_name>Darko Vončina</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-3439</code><acronim><![CDATA[ENVISaGE]]></acronim><duration>03.04.2019 - 02.04.2023</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Agronomski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Agriculture]]></institution_en><team_members_id>26015</team_members_id><team_members_names><![CDATA[ Doktorand: Martin  Jagunić ]]></team_members_names><keywords_hr><![CDATA[detekcija, distribucija, prijenos, zeljasti domaćini, biološke karakteristike, ozdravljivanje, utjecaj, elektronska mikroskopija]]></keywords_hr><keywords_en><![CDATA[detection,distribution, transmission, herbaceous hosts, biological properties, sanitation, impact, electron microscopy]]></keywords_en><summary_hr><![CDATA[Vinova loza je jedna od najstarijih kultura koja se uzgaja u svim dijelovima svijeta gdje za to  vladaju povoljni klimatski uvjeti. Osim povoljnih uvjeta za uzgoj, Hrvatsku karakterizira značajan broj autohtonih sorata vinove loze, a vinogradarstvo predstavlja važan dio nacionalnog gospodarstva. Do danas je kod loze utvrđeno više od 75 različitih virusa.  Virusne bolesti predstavljaju veliki ekonomski problem u poljoprivrednoj proizvodnji širom svijeta, posebno kod kultura s vegetativnim razmnožavanjem. Njihova kontrola se  uglavnom temelji na suzbijanju poznatih vektora (insekti, grinje, nematode), korištenju bezvirusnog sadnog materijala i konstantnom radu na klonskoj i zdravstvenoj selekciji. Uvođenjem tehnike sekvenciranja nove generacije (NGS) u dijagnostiku biljnih patogena, nekoliko novih virusa potvrđeno je u vinovoj lozi. Dva nova virusa, uvjetno nazvana G-virus vinove loze i badnavirus vinove loze 1, nedavno su primjenom NGS metode pronađeni kod hrvatskih autohtonih sorata. Međutim, biološki podaci o nedavno otkrivenim virusima vrlo su ograničeni ili ne postoje, a sposobnost otkrivanja velikog broja mogućih patogena ograničene je primjenjivosti ako ne postoje istraživanja koja opisuju njihove uloge i kako smanjiti njihov negativan utjecaj na ekonomski značajne kulture. Uzimajući u obzir  dogmu da se svi virusi smatraju patogenima dok se ne dokaže drugačije, cilj projekta je detaljnije istražiti dva nova virusa vinove loze. Projekt će rezultirati robusnim i pouzdanim testovima za detekciju dva virusa, podacima o njihovoj morfologiji i rasprostranjenosti u Hrvatskoj, načinu prijenosa (mehanički, vektori, sjeme, cijepljenje), alternativnim domaćinima, mogućnosti uklanjanja iz zaraženih biljaka i utjecaja na fiziološke procese kod različitih sorata u normalnim i sušnim uvjetima. Projekt će dati korisne podatke o ekonomskoj važnosti novih virusa, potrebi za regulacijom (karantena ili uvoz/ izvoz) zajedno s mogućnostima njihove odgovarajuće kontrole.]]></summary_hr><summary_en><![CDATA[Grapevine is one of the oldest crop cultivated in all parts of the word with appropriate climatic conditions. Beside favorable conditions for grapevine production, Croatia is characterized by significant number of autochthonous cultivars and viticulture is representing important branch of national economy. Up to date over 75 different viruses have been identified from grapevine. Viral diseases are currently a major economic problem in agriculture throughout the world, especially in crops with vegetative propagation. Their management is mainly based on control of known vectors (insects, mites, nematodes), use of virus-free planting material and constant work on clonal and sanitary selection. With implementation of next generation sequencing (NGS) in diagnostic of plant pathogens several novel viruses from grapevine were reported. Two novel viruses, tentatively named grapevine virus G and grapevine badnavirus-1, were recently reported from Croatian autochthonous grapevine varieties using NGS. However, biological information about recently reported viruses is very limited or non-existent, and the ability to detect large number of putative pathogens is of limited applied value if there are no studies describing their respective roles or how to reduce their impact to a crop of economic importance. Challenging the dogma that all viruses are considered pathogens till proved otherwise, aim of the project is detailed investigation or two novel viruses reported from Croatia. Project will resulted in robust detection assays for novel viruses, data about their morphology and distribution in Croatia, modes of spread (mechanical, vectors, seed, grafting), alternative hosts, sanitation and impact on physiological process of different grapevine varieties under normal and dry conditions. Project will generate beneficial data about economic importance of novel viruses, need for regulation (quarantine or import/export) together with options for appropriate management.]]></summary_en></project><project>
<id>7990</id><title_hr><![CDATA[Doprinos interne komunikacije uspješnosti organizacije: položaj, kanali,  mjerenje i odnos s povezanim konceptima]]></title_hr><title_en><![CDATA[]]></title_en><user_id>23352</user_id><user_firstLast_name>Ana Tkalac Verčič</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-7071</code><acronim><![CDATA[IntComORG]]></acronim><duration>18.04.2019 - 18.07.2023</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, </scie_field_hr><scie_field_en>Economy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Ekonomski fakultet u Zagrebu]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Economics and Business]]></institution_en><team_members_id>26347</team_members_id><team_members_names><![CDATA[ Doktorand: Anja Špoljarić ]]></team_members_names><keywords_hr><![CDATA[Interna komunikacija, Reputacija, Angažiranost, Marka poslodavca, Psihološki ugovor]]></keywords_hr><keywords_en><![CDATA[Internal communication, Reputation, Engagement, Employer brand, Psychological contract]]></keywords_en><summary_hr><![CDATA[Istraživanja pokazuju kako se svugdje u svijetu povjerenje zaposlenika u vodstvo organizacije smanjuje (Jiang i Probst, 2015; Coats, 2005; Tanner, 2011). Dodatne promjene koje pridonose većoj važnosti interne komunikacije uključuju smanjenja broja zaposlenika,  velike razlike u primanjima prosječnih zaposlenika i vodstva te masovne otkaze i njihov utjecaj na stupanj odanosti zaposlenika (Tkalac Verčič, 2016). Za internu komunikaciju u organizaciji to znači povećanu potrebu za iskrenom dvosmjernom komunikacijom. Globalizacija povećava usredotočenost na internu komunikaciju (Erkkila, 2010) kao i tehnologija koja je ubrzala povezivanje tržišta i organizacija (Mitić, Nikolić, Jankov, Vukonjanski i Terek, 2017). Osnovni cilj ovog projekta je proučavanje, definiranje i povezivanje pojedinih elemenata interne komunikacije s organizacijskom reputacijom putem medijatornih varijabli koje uključuju angažiranost zaposlenika, marku poslodavca, stupanj ispunjenosti psihološkog ugovora i percipiranu organizacijsku podršku. Povezivanje varijabli interne komunikacije s varijablama organizacijske uspješnosti najbolji je način mjerenja i time jasnijeg ustrojavanja funkcije interne komunikacije u organizaciji. Konačna svrha projekta je proširenje i prilagodba definicije interne komunikacije kako bi operacionalizacija precizno i realno odražavala stanje u organizacijskom okruženju; utvrđivanje položaja organizacijskog smještaja interne komunikacije te utvrđivanje mjera uspješnosti interne komunikacije koje se provode u hrvatskim organizacijama. Posebna pažnja biti će posvećena obilježjima internih javnosti, načinima segmentacije, društvenim medijima, angažiranosti zaposlenika, komunikaciji promjena, komunikaciji vodstva i načinima mjerenja i evaluacije. Istraživanje povezanosti zadovoljstva internom komunikacijom i razine angažiranosti zaposlenika značajno je za organizacijsku uspješnost baš kao i istraživanje potencijalne veze s markom poslodavca i reputacijom organizacije. ]]></summary_hr><summary_en><![CDATA[Research shows that all around the world employee trust in organizational leadership is declining (Jiang & Probst, 2015; Coats, 2005; Tanner, 2011). Additional changes that emphasize the significance of internal communication include huge differences in salaries between average employees and top management, mass employee reductions and the effect this has on the level of employee loyalty. For internal communication this means an increased need for open two-way communication. Globalization also increases focus on internal communication (Erkkila, 2010) as well as technology which brings markets and organizations even closer together (Mitić, Nikolić, Jankov, Vukonjanski & Terek, 2017). The main goal of this project is exploring, defining and connecting various elements of internal communication with organizational reputation through mediating variables which include employee engagement, employer brands, psychological contract fulfillment and perceived organizational support. Linking internal communication variables with indicators of organizational success is the best way to measure and establish internal communication as an organizational function. Connecting the level of internal communication satisfaction and the level of employee engagement is important for long term organizational success as is the potential connection with employer brands and organizational reputation.  The final goal of the project is to define internal communication in a way that will realistically and precisely reflect the situation in the organizational environment, to determine the typical position internal communication has in an organization and to define which measures of success are the best for internal communication in organizations. Special attention will be focused on characteristics of internal publics, typical segmentation techniques, social media choices, the level of employee engagement, change communication, leadership communication and measurement and evaluation techniques. ]]></summary_en></project><project>
<id>7991</id><title_hr><![CDATA[Ekologija i toksičnost vrsta roda Pseudo-nitzschia u obalnim vodama srednjeg i južnog Jadrana]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5818</user_id><user_firstLast_name>Jasna Arapov</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-1195</code><acronim><![CDATA[PSEUDOTOX]]></acronim><duration>16.09.2019 - 06.03.2026</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut za oceanografiju i ribarstvo]]></institution_hr><institution_en><![CDATA[Institute of Oceanography and Fisheries]]></institution_en><team_members_id>28773</team_members_id><team_members_names><![CDATA[ Doktorand: Tina Pavelin ]]></team_members_names><keywords_hr><![CDATA[Pseudo-nitzschia, taksonomija, toksičnost, molekularne analize, Jadransko more]]></keywords_hr><keywords_en><![CDATA[Pseudo-nitzschia, taxonomy, toxicity, molecular analyses, Adriatic Sea]]></keywords_en><summary_hr><![CDATA[Projektni prijedlog obuhvaća ekološko i taksonomsko istraživanje potencijalno toksičnog fitoplanktonskog roda Pseudo-nitzschia.  Danas ovaj rod dijatomeja čini 60 vrsta od kojih se polovica smatra toksičnim. Međutim, zbog postojanja kriptičnih i pseudo-kriptičnih vrsta determinacija vrsta roda Pseudo-nitzschia moguća je jedino kombiniranom primjenom molekularnih i morfoloških analiza. Glavni cilj predloženog istraživanja je uspostava istraživačke grupe koja će uvesti nove, dosad nekorištene istraživačke metode: Sanger sekvenciranje, DNA-metabarcoding i transmisijsku elektronsku mikroskopiju, u svrhu morfološke i molekularne karakterizacije populacija Pseudo-nitszchia. Istraživanje će se provesti tijekom jedne godine na četiri najvažnija uzgojna i izlovna područjima za školjkaše srednjeg i južnog Jadrana. Terenskim istraživanjem prikupit će se uzorci okolišnih i bioloških parametara kako bi se odredili uvjeti koji pogoduju razvoju Pseudo-nitzschia vrsta. Primjenom novih metoda detaljno će se odrediti sastav istraživanog roda i uspostaviti stanične kulture. Toksičnost staničnih kultura određivati će se pri standardnim i izmijenjenim uzgojnim uvjetima u eksprimentalnom dijelu projekta. Najvažniji znanstveni doprinos predloženog istraživanja će biti detaljno određivanje taksonomskog stastava roda Pseudo-nitzschia na istraživanim područjima, koje će za područje južnog Jadrana predstavljati prve podatke. Predloženim istraživanjem dobit će se prve saznanja o toksičnosti istraživanog roda, a rezultati analize DNA planktonske zajednice upotpuniti će dosadašnja taksonomska istraživanja elektronskom mikroskopijom. Rezultati istraživanja objavit će se u četiri znanstvena rada. Prikupljeni podaci bit će temelj za buduća istraživanja roda Pseudo-nitzshcia u Jadranskom moru.]]></summary_hr><summary_en><![CDATA[The project proposal covers an ecological and taxonomic study of the potentially toxic phytoplankton genus Pseudo-nitzschia. This genus of diatoms consists of 60 species, half of which are considered toxic. However, due to the existence of cryptic and pseudo-cryptic species, the determination of species of the genus Pseudo-nitzschia is only possible through the combined application of molecular and morphological analyses. The main objective of the proposed research is to establish a research group that will introduce new, previously unused research methods: Sanger sequencing, DNA metabarcoding and transmission electron microscopy, for the purpose of morphological and molecular characterisation of Pseudo-nitzschia populations. The research will be carried out during one year at four most important breeding and fishing areas for shellfish in the central and southern Adriatic. Field sampling of environmental and biological parameters will be carried out to determine conditions that favors the development of Pseudo-nitzschia species. The use of new methods will determine in detail the composition of the genus under study and establish cell cultures. Cell culture toxicity will be determined under standard and modified breeding conditions in the experimental part of the project. The most important scientific contribution of the proposed research will be to determine in detail the taxonomic status of the genus Pseudo-nitzschia in the studied areas, which will be the first data for the southern Adriatic area. The proposed research will gain the first knowledge about the toxicity of the studied genus, and the results of  analysis of the DNA of the planktonic community will complement current taxonomic research by electron microscopy. The research results will be published in four scientific papers. The data collected will be the basis for future research into the genus Pseudo-nitzschia in the Adriatic Sea.]]></summary_en></project><project>
<id>7992</id><title_hr><![CDATA[KeepWarm - Improving the performance of district heating systems in Central and East Europe]]></title_hr><title_en><![CDATA[]]></title_en><user_id>20175</user_id><user_firstLast_name>Ankica Kovač</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-9405</code><acronim><![CDATA[]]></acronim><duration>23.04.2019 - 01.10.2023</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, </scie_field_hr><scie_field_en>Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>26266</team_members_id><team_members_names><![CDATA[ Doktorand: Matej Paranos ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>7993</id><title_hr><![CDATA[Sustav potpore odlučivanju za zeleniju i sigurniju plovidbu brodova]]></title_hr><title_en><![CDATA[]]></title_en><user_id>21407</user_id><user_firstLast_name>Jonatan Lerga</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-7233</code><acronim><![CDATA[DESSERT]]></acronim><duration>10.04.2019 - 10.04.2023</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Tehnički fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Engineering]]></institution_en><team_members_id>25744</team_members_id><team_members_names><![CDATA[ Doktorand: Denis Selimović ]]></team_members_names><keywords_hr><![CDATA[sustav potpore odlučivanju, pomorstvenost, spektar valova, optimizacija rute, mjerenje, emisija stakleničkih plinova]]></keywords_hr><keywords_en><![CDATA[decision support system, seakeeping, wave spestra, route optimisation, measurements, greenhouse gases emissions]]></keywords_en><summary_hr><![CDATA[Cilj istraživanja u okviru projekta Sustav potpore odlučivanju za zeleniju i sigurniju plovidbu brodova (DESSERT) je razvoj učinkovitog sustava potpore odlučivanju (Decision Support System - DSS) kapetanima broda, kao i zapovjednicima stroja, a koji bi doprinio ”zelenijoj” i sigurnijoj plovidbi brodova. Krajnji učinak takvog DSS bilo bi svođenje ljudske pogreške na što manju mjeru, odnosno pružanje odgovornim osobama na brodu maksimalno vjerodostojne podatke i smjernice tijekom plovidbe kako bi se smanjilo onečišćenje okoliša i kako bi ljudi i teret bili što sigurniji. Istraživanja vezana uz razvoj DSS-a odvijat će se u dva osnovna smjera: energetski učinkovitija plovidba uz smanjenje emisije stakleničkih plinova; i povećanje sigurnosti plovidbe s aspekta izbjegavanja sudara i s aspekta pravovremenih reakcija u slučaju naplavljivanja broda.U okviru istraživanja planira se osmišljavanje, provedba i analiza upitnika (anketa) koji su namijenjeni kapetanima i upraviteljima stroja na brodovima. Namjera je dobivanje što vjerodostojnijih podataka o reakciji posade na pojedine dinamičke učinke uzrokovane pogoršanjem vremenskih uvjeta. Analizom anketa planira se dobiti povratne podatke o kriterijima i graničnim vrijednostima kriterija koji su mjerodavni za namjernu promjenu brzine ili kursa zbog pretjeranog njihanja broda na valovima, te razviti model “virtualnog kapetana” koji bi se koristio prilikom simulacije i planiranja rute plovidbe. Značajan znanstveni doprinos istraživanja vezan je za brodska pogonska postrojenja. Cilj je razviti sustav potpore odlučivanju na brodu uzimajući u obzir projektantsku, strojarsku i pomorsku ekspertizu u cilju stvaranja sigurnog i ekološki učinkovitog ili &#39;&#39;zelenijeg&#39;&#39; broda i plovidbe. Projektni tim sastoji se od znanstvenika koji su stručnjaci u brodogradnji, strojarstvu,  pomorskom inženjerstvu i računarstvu koji omogućuju multidisciplinarno rješavanje ovog problema.]]></summary_hr><summary_en><![CDATA[The goal of the research in a frame of project DEcision Support System for green and safE ship RouTing – DESSERT is the development of an effective Decision Support System (DSS) is planned for ship captains as well as machine commanders, which would contribute to &#39;&#39;greener&#39;&#39; and safer navigation of ships. The ultimate impact of such a DSS would be to make human error as small as possible, or to provide responsible persons on board the most credible data and guidance during navigation to reduce environmental pollution and make people and cargo safer.Research related to the development of DSS will take place in two main directions: energy-efficient navigation along with reduction of greenhouse gas emissions; and increase sailing safety by collision avoidance as well as from timely reactions in the event of flooding. Within the scope of the survey, the design, implementation and analysis of questionnaires (surveys) designed for captains and engineers on ships are planned. The intention is to get the most credible data on the crew response to the individual dynamic effects caused by the worsening of weather conditions. Survey analysis is designed to get feedback on the criteria and limit values of the criteria that are relevant to deliberate speed or course change due to excessive ship motions on waves, and to develop a &#39;&#39;virtual captain&#39;&#39; model to be used when simulating and planning the navigation route. Significant scientific contribution to research is related to ship propulsion plants. The objective is to develop decision support system on board taking into accounts the environmental issue, creating a so called safe and eco-efficient or “green” ship. The project team consists of the scientists who are experts in the naval architecture, mechanical engineering, marine engineering field and computational sciences which allow solving this problem multidisciplinary.]]></summary_en></project><project>
<id>7994</id><title_hr><![CDATA[Genetički i epigenetički biomarkeri urođene imunosti u KOPB-u i karcinomu pluća]]></title_hr><title_en><![CDATA[]]></title_en><user_id>13083</user_id><user_firstLast_name>Jelena Knežević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-6350</code><acronim><![CDATA[LungInflaCare]]></acronim><duration>10.05.2019 - 10.09.2023</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>27624</team_members_id><team_members_names><![CDATA[ Doktorand: Jurica Baranašić ]]></team_members_names><keywords_hr><![CDATA[KOPB, tumori pluća, urođena imunost, receptori, genetika, epigenetika, biomarkeri]]></keywords_hr><keywords_en><![CDATA[COPD, lung cancer, innate immunity, receptors, genetic, epigenetic, biomarkers]]></keywords_en><summary_hr><![CDATA[Kronična opstruktivna plućna bolest (KOPB) i tumori pluća vodeći su uzroci smrtnosti u svijetu. Usko su povezani i dijele zajedničke faktore rizika, pušenje i genetičku predispoziciju. Naime, samo 20% pušača razvije KOPB ili tumor pluća, dok prisutnost KOPB-a, definiranog smanjenim ekspiratornim volumenom zraka u 1 sekundi (FEV1), povećava rizik nastanka tumora pluća za 4 do 5 puta. Mehanistička povezanost KOPB-a i tumora pluća još uvijek je nedovoljno poznato, vjerojatno zbog heterogene kliničke slike obje bolesti.Urođeni imunološki odgovor neophodan je za održavanje zdravlja pluća i tkivne homeostaze, no nekontrolirana upala povezuje se s nastankom KOPB-a i tumora pluća. Stanice dišnog epitela i imunosne stanice eksprimiraju različite receptore za specifično prepoznavanje određenih uzoraka (eng. pattern recognition receptors, PPR) koji su sudjeluju u reakciji urođenog imunološkog odgovora na patogene i molekule koje mogu oštetiti tkivo. Poznato je da je dugotrajna i opsežna upala dovoljan rizični faktor za nastanak KOPB-a i karcinoma pluća. Međutim, još uvijek je potpuno nepoznato kako je genetička raznolikost receptora urođene imunosti povezana s regulacijom upale u plućima i dišnim putevima i kako ti procesi doprinose razvoju KOPB-a i nastanku tumora na molekularnoj i staničnoj razini. Također, histološka i molekularna heterogenost tumora pluća samog po sebi, otežava naše razumjevanje karcinogeneze i liječenja obje bolesti. Obzirom na veliku učestalost i snažnu povezanost KOPB-a i tumora pluća i nepostojanje adekvatne terapije za obje bolesti, identifikacija specifičnih genetičkih varijanti i rasvjetljavanje njihove uloge u bolesnim stanjima pridonijeti će liječenju bolesti na osobnom nivou. Stoga su specifični ciljevi predloženog projekta sažeti u dva radna područja:1. Identifikacija genetičkih i epigenetičkih faktora rizika zajedničkih KOPB-u i tumorima pluća2. Utvrđivanje mehanističke poveznice KOPB-a i TP-a uzimajući u obzir ulogu receptora urođene imunosti]]></summary_hr><summary_en><![CDATA[Chronic obstructive pulmonary disease (COPD) and lung cancer (LC) are leading causes of morbidity and mortality worldwide. They are closely related and share cigarette smoke as a common environmental risk factor. Genetic predisposition is also shared; only minority of smokers (20%) develops LC or COPD. The presence of COPD, defined as reduced forced expiratory volume in 1 second (FEV1), increases the risk to development of LC up to 4,5 fold. The mechanistic explanation of this finding is still poorly understood, likely due to heterogeneous nature of diseases. Innate immune response is essential for maintaining lung health and tissue homeostasis but unbalanced inflammation of lungs is associated with diseased conditions, such as COPD and LC. Pulmonary epithelial and immune cells are equipped with pattern recognition receptors (PRRs) able to initiate appropriate innate immune response to invading pathogens or tissue damage associated molecules. It is well known that excessive inflammation is sufficient to confer risk to both diseases. There is still lack of knowledge how genetic variability of innate immunity receptors orchestrate inflammation in lungs and how these processes contribute to development of both diseases, on molecular and cellular level. Also, the histological and molecular heterogeneity of LC, by itself, makes our understanding of carcinogenesis, as well as treatment of disease challenging. Because of global increase in COPD and LC prevalence, strong association of COPD with lung cancer and absence of specific therapeutic targets for both disease, identification of specific gene variants and their involvement in diseased conditions will improve disease treatment at personalized level. The specific aims of this project could be summarized in two work areas:1. Identification of shared genetic and epigenetic risk factors/biomarkers for COPD and LC2. Determination of common mechanistic link of COPD and LC considering the role of innate immunity receptors]]></summary_en></project><project>
<id>7996</id><title_hr><![CDATA[Konsocijacija drvenastih vrsta i poljoprivrednih kultura kao inovativni pristup u agroekosustavima]]></title_hr><title_en><![CDATA[]]></title_en><user_id>20421</user_id><user_firstLast_name>Vladimir Ivezić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-9785</code><acronim><![CDATA[AGROINOVA]]></acronim><duration>07.03.2019 - 08.07.2023</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Fakultet agrobiotehničkih znanosti Osijek]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Agrobiotechnical Sciences in Osijek]]></institution_en><team_members_id>28689</team_members_id><team_members_names><![CDATA[ Doktorand: Helena Žalac ]]></team_members_names><keywords_hr><![CDATA[konsocijacija, orah, poljoprivredni usjevi, mikroklima, biološka raznolikost, konzervacija tla]]></keywords_hr><keywords_en><![CDATA[Intercopping, walnut, agricultural crops, microclimate, biodiversity, soil conservation]]></keywords_en><summary_hr><![CDATA[Konsocijacija ili kombinacija kultura podrazumijeva uzgoj više kultura na istoj površini u isto vrijeme. Glavne prednosti konsocijacije su: bolja iskoristivost proizvodne površine, pozitivan utjecaj na plodnost tla, raznolikost proizvodnje u jednoj vegetaciji, zaštita od pojave bolesti, štetnika i korova, bolja iskoristivost hraniva i vode u tlu te povećana biološka raznolikost. U konsocijacijama koje podrazumijevaju uzgoj u nasadima oraha poželjno je odabrati nasade s cijepljenim orasima zbog činjenice da orah luči juglon koji može imati toksičan efekt na nicanje drugih biljaka. Naime, u nasadima oraha s cijepljenim stablima lučenje juglona nije tako intenzivno i djelovanje juglona u prvih 15 godina u takvim nasadima nema značajno toksičan učinak. Isto tako, preporučljivo je unošenje organske tvari jer se time potiče mikrobiološka aktivnost koja pospješuje razgradnju juglona. Drugi važan čimbenik u ovakvim konsocijacijama jest odabir poljoprivrednih kultura koje su otporne na nisku pH vrijednost jer orah eksudatima zakiseljuje tlo.Cilj projektnog prijedloga je istražiti utjecaj međuodnosa cijepljenih oraha i poljoprivrednih kultura na mikroklimu te time na bioraznolikost u tlu (mikrobiološku aktivnost u tlu te strukture zajednice nematoda), konzervaciju tla i štetne organizme poput uzročnika biljnih bolesti. Pokus će biti proveden kroz pet godina, na dva lokaliteta u dvije županije od kojih će se svaki sastojati od tri parcele – kontrolna parcela sa usijanim poljoprivrednim kulturama bez oraha, parcela s nasadom oraha gdje će između redova biti usijane poljoprivredne kulture te trajni nasad oraha bez ratarskih kultura. Na osnovu dobivenih rezultata biti će kreiran kompjuterski model za predviđanje utjecaja mikroklime na istraživane parametre u projektnom prijedlogu. Iako su takvi modeli dostupni u svijetu u Republici Hrvatskoj ovo će biti prvi model takvog tipa koji će biti primjenjiv za agroekološke uvijete u široj regiji, odnosno područje dunavskog sliva.  ]]></summary_hr><summary_en><![CDATA[Intercropping or a combination of plant species involves more species on the same parcel at the same time. The main benefits of the intercropping are: better use of the production area, positive influence on soil, diversity of production, protection against plant disease, pests and weeds, better use of nutrients and water in soil as well as increased biodiversity. In intercropping systems with walnut it is desirable to choose orchards with grafted plants since the walnut tree secretes juglone that may have a toxic effect on the germination of other plants. In the orchards of walnuts with grafted trees, the secretion of juglone is not so intense and the activity of the juglone in the first 15 years in such intercropping systems has no significant toxic effect. Also, it is advisable to introduce organic matter as it promotes microbiological activity that decompose juglone. Another important factor in such systems is the selection of plants resistant to low-pH, since the walnuts can acidify soil.The aim of the proposed project is to investigate the interaction between grafted walnuts and agricultural crops to microclimate and consequently to soil biodiversity (microbiological activity in soil and nematode community structure), soil conservation and occurrence of plant diseases.The field trial will be conducted during five years, at two locations in two Counties, each field trial will consist of three parcels - control plot of agricultural crops without walnuts, walnut orchards with intercropped agricultural crops and a permanent walnut orchard without intercropped agricultural crops. Based on the obtained results, a computer model will be created for predicting the influence of microclimate on the investigated parameters in the project proposal. Although such models are available worldwide in the Republic of Croatia, this will be the first model of such type that will be applicable for agroecological conditions in the wider region, mainly the Danube Basin area.]]></summary_en></project><project>
<id>7997</id><title_hr><![CDATA[Zdravstvene, kulturne i biološke odrednice dugovječnosti: antropološka studija preživljenja u dubokoj starosti]]></title_hr><title_en><![CDATA[]]></title_en><user_id>12597</user_id><user_firstLast_name>Tatjana Škarić-Jurić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-8382</code><acronim><![CDATA[HECUBA]]></acronim><duration>01.03.2020 - 29.02.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Javno zdravstvo i zdravstvena zaštita, </scie_field_hr><scie_field_en>Public health and health services, </scie_field_en><institution_hr><![CDATA[Institut za antropologiju]]></institution_hr><institution_en><![CDATA[Institute for Anthropological Research]]></institution_en><team_members_id>29632</team_members_id><team_members_names><![CDATA[ Doktorand: Maja Šetinc ]]></team_members_names><keywords_hr><![CDATA[starenje, dugovječnost, funkcionalna sposobnost, zdravlje, kultura, biologija]]></keywords_hr><keywords_en><![CDATA[ageing, longevity, functional ability, health, culture, biology]]></keywords_en><summary_hr><![CDATA[Osobe duboke starosti ogledan su primjer uspješnog starenja. Stoga je 2007. - 2009. provedeno antropološko istraživanje u zagrebačkim domovima za starije i nemoćne osobe u sklopu kojeg je za 300 osoba starih 85 i više godina prikupljen širok spektar podataka (anketni, biometrijski, DNA uzorci) koji čine polazište predloženog istraživanja. Protok vremena od 10 godina od inicijalnog istraživanja daje prvorazrednu mogućnost utvrđivanja dvaju ključnih ishoda: duljine života ispitanika (te izdvajanje poduzorka uistinu dugovječnih osoba) i duljine razdoblja njihove funkcionalne sposobnosti. Obje vrste ishoda predstavljaju krajnje točke prema kojima se mogu ocjenjivati sve mjerene značajke ispitanika te detektirati one koje obilježavaju uspješno starenje. Cilj je predloženog istraživanja da sveobuhvatno istraži utjecaj ne samo pojedinih bioloških odrednica i zdravstvenog stanja, već i socioekonomskih i psiholoških odlika kao i utjecaja osobne povijesti te čimbenika kulture (stavova, ponašanja, navika) na dinamiku procesa starenja. U sklopu projekta dodatno će se izvršiti genotipizacija „gena dugovječnosti“ i duljine telomera te regrutirati uzorak mladih odraslih osoba za komparativne genetičke analize. Utvrdit će se i učestalost rizičnih varijanti farmakogenetički relevantnih ADME gena koje mogu dovesti do štetnih djelovanja pri uzimanju pojedinih lijekova, što s obzirom na polipragmaziju prisutnu u ovoj dobnoj skupini predstavlja specifičan praktični doprinos projekta. Istraživanje povezanosti dvaju ključnih ishoda s biološkim, zdravstvenim i sociokulturnim obilježjima provest će multidisciplinarni tim stručnjaka iz različitih znanstvenih područja (medicina, biologija, antropologija, psihologija, ekonomija). Očekuje se da predloženo istraživanje fenomena dugovječnosti doprinese suvremenim teorijama starenja, ali i da ono urodi rezultatima koji bi mogli imati implikacije za gerontološku i gerijatrijsku praksu te za planiranje javnozdravstvenih i socijalnih politika u RH.]]></summary_hr><summary_en><![CDATA[Persons of very old age may be a particularly useful model for successful ageing. Within the extensive anthropological survey of 300 oldest old persons (85+ yrs) conducted in 2007/09 in retirement homes in Zagreb, a wide spectrum of data from face-to-face interviews, biometry and blood samples was collected that forms the basis for proposed research. The period of 10 years that elapsed since this initial study offers now a first class possibility to detect the two key outcomes: the examinees&#39; survival time (and selection of exceptionally long-lived subsample) and the duration of their preserved functional ability. Both outcomes represent the endpoints according to which all studied traits will be assessed in order to elucidate those that have a crucial role in successful ageing. While most studies have focused on particular aspects of human longevity, the proposed project aims at investigating comprehensively the impact of numerous biological and health-related features along with different socioeconomic and psychological traits as well as life history and cultural factors (attitudes, behavior, habits). Additional data will be generated through genotyping of „longevity genes“ and telomeres’ length in long-lived and in newly recruited comparative sample of young persons. Also, genotyping of the pharmacogenetically relevant ADME genes will be performed in order to determine the frequency of their risk variants for adverse reactions to drugs which is of high practical importance due to the existing polypragmasy in advanced age. To achieve the aims of the project, a multidisciplinary team of investigators from the fields of anthropology, medicine, biology, psychology and economy has been set up. The proposed investigation of successful ageing and longevity is expected to contribute to the current theories of ageing and to bring results relevant for gerontological and geriatric practice and for planning the public health and social policies in the Republic of Croatia.]]></summary_en></project><project>
<id>7998</id><title_hr><![CDATA[Održivost javnih financija na putu u monetarnu uniju]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3265</user_id><user_firstLast_name>Hrvoje Šimović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-9533</code><acronim><![CDATA[PuFiSuMU]]></acronim><duration>02.05.2019 - 02.11.2023</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, </scie_field_hr><scie_field_en>Economy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Ekonomski fakultet u Zagrebu]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Economics and Business]]></institution_en><team_members_id>26392</team_members_id><team_members_names><![CDATA[ Doktorand: Marija  Davidović ]]></team_members_names><keywords_hr><![CDATA[Fiskalna održivost, monetarna unija, javni dug, fiskalni multiplikatori, narativni pristup, mala i otvorena ekonomija, model opće ravnoteže, Hrvatska]]></keywords_hr><keywords_en><![CDATA[Fiscal sustainability, monetary union, public debt, fiscal multipliers, narrative approach, small and open economy, general equilibrium models, Croati]]></keywords_en><summary_hr><![CDATA[U posljednjem desetljeću Hrvatska je prošla dinamičan ekonomski i politički put koji je bio obilježen sa šest godina recesije i ulaskom u EU. Navedeno razdoblje karakterizirala je neusklađenost ekonomskih politika i nedostatak konzistentne fiskalne politike uzrokovane političkom nestabilnosti (3 koalicijske Vlade, 4 premijera, 5 ministra financija), ali i sustavne nespremnosti Vlada na provođenje suštinske fiskalne konsolidacije. Diskrecijske mjere u najvećoj su se mjeri svodile na povećanje porezne presije radi smanjivanja deficita, dok se na rashodnoj strani provodila tzv. politika nečinjenja što je rezultiralo izostankom strukturnih reformi. Takva politika rezultirala je eksplozijom javnog duga (s 36% na 85% BDP-a od 2008-15). U međuvremenu je snižen kreditni rejting na špekulativnu razinu te je aktiviran postupak prekomjernog deficita (EDP) i postupak prekomjernih makroekonomskih neravnoteža (MIP). U uvjetima slabog rasta (oko 2%) i fiskalne neodrživosti (kamate iznose oko 3,5% BDP-a), nositeljima ekonomske politike posao dodatno otežava činjenica da Hrvatska u svojoj europskoj perspektivi ima obavezu uvođenja Eura.Osnovi cilj predloženog projekta je analiza i evaluacija održivosti javnih financija u Hrvatskoj te projekcija dinamike javnog duga s ciljem postizanja potrebnih kriterija konvergencije i uvođenja Eura. Očekivani rezultati istraživanja dali bi cjelovitu sliku mogućnosti fiskalne i monetarne politike da u srednjem roku osvare preduvjete za ulazak Hrvatske u monetarnu uniju. Kao krajnji cilj trebalo bi se utvrditi optimalno razdoblje i tranzicijski trošak ulaska i uvođenje Eura, kao i sve ekonomske pretpostavke za ostvarivanje predloženog scenarija.]]></summary_hr><summary_en><![CDATA[In the last decade Croatia has experienced a dynamic economic and political path during which Croatia struggled with six years of recession and joined the EU. The observed period was characterized by uncoordinated economic policies and the lack of consistent fiscal policy partially due to the political instability (3 coalition governments, 4 Prime Ministers, 5 Ministers of Finance), but also because of the lack of government’s efforts to implement substantial fiscal consolidation. Discretionary measures were mainly conducted by increasing taxes in order to reduce the budget deficit, while government spending was led by the “policy of doing nothing” which resulted with the absence of structural reforms. Aforementioned policies resulted in public debt explosion (36% to 85% GDP in 2008-15). In the meanwhile, credit-rating was downgraded to the speculative level, and the EC activated Excessive deficit procedure (EDP) and Macroeconomic imbalances procedure (MIP). Need for fiscal consolidation in the period of slow economic growth (around 2%) and fiscal unsustainability (interest expenses amount to 3.5% of GDP) are even more challenging having in mind the fact that economic and political EU future includes (obligatory) adoption of the Euro. The overall goal of the proposed project is to analyse and evaluate Croatia’s public finance sustainability and to estimate public debt dynamics in order to fulfil convergence criteria and adopt the Euro. Expected results of this research should provide an overview of the possibilities of fiscal and monetary policies in the mid-term to create the preconditions for the Croatian accession to the EMU. The ultimate goal is to determine the target date for Croatia&#39;s accession, evaluate transition cost of adopting the Euro and to determine all economic requirements in order to achieve that goal. ]]></summary_en></project><project>
<id>7999</id><title_hr><![CDATA[Regulacija GLI koda u tumorima ovisnim o BRAF/NRAS mutacijama]]></title_hr><title_en><![CDATA[]]></title_en><user_id>19584</user_id><user_firstLast_name>Maja Sabol</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-8653</code><acronim><![CDATA[GLIcode]]></acronim><duration>03.05.2019 - 02.05.2023</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>28631</team_members_id><team_members_names><![CDATA[ Doktorand: Nikolina Rinčić ]]></team_members_names><keywords_hr><![CDATA[Signalni put Hedgehog, BRAF, NRAS, melanom, GLI]]></keywords_hr><keywords_en><![CDATA[Hedgehog signaling, BRAF, NRAS, melanoma, GLI]]></keywords_en><summary_hr><![CDATA[Signalni put Hedgehog povezan je s nastankom raznih tumora, ali točni mehanizmi djelovanja još nisu u potpunosti razjašnjeni. Fokus ovog istraživanja su tumori s mutacijama u genima BRAF ili NRAS, te njihov odgovor na inhibiciju signalnog puta Hedgehog. BRAF i NRAS nekanonički aktiviraju sva tri proteina GLI, ali točan slijed i djelovanje ovih interakcija još nisu razjašnjeni. Ovim projektom planiramo odrediti točne transkripcijske mete proteina GLI1, GLI2 i GLI3 u melanomima s različitim genetičkim podlogama: mutacijom u BRAF, mutacijom u NRAS, ili bez mutacije u ova dva gena. Stoga ćemo prvo provesti analizu ChIP-seq kako bismo odredili točne transkripcijske mete ovih proteina. Nakon toga uklonit ćemo gene za svaki od tih proteina („knock-out“) i sekvencirati transkriptome tih staničnih linija. Nakon izrade „knock-out“ linija, testirat ćemo ih nizom testova kako bismo odredili ulogu svakog od tri proteina GLI u tumorima ovisnim o BRAF/NRAS mutacijama, te kako bismo razjasnili mehanizam njihovog djelovanja u melanomima. Kombiniranim tretmanima inhibitorima signalnog puta Hedgehog i specifičnim inhibitorima BRAF/NRAS, te izradom i testiranjam staničnih linija otpornih na te lijekove, pokazat ćemo postoji li pozitivan učinak za potencijalno liječenje melanoma. Sve ove analize pokazat će nam mogu li se proteini GLI ili njihovi ciljni geni koristiti kao potencijalni biomarkeri za melanom. Na kraju, u zadnjoj godini projekta, analizirat ćemo set kliničkih uzoraka na te potencijalne biomarkere, kako bismo procijenili njihovu moguću primjenu u klinici. Ukratko, ovim projektom u planu je kompletna analiza GLI koda u melanomima ovisnim o BRAF/NRAS mutacijama, od određivanja transkripcijskih meta i pronalaženja molekularnih mehanizama do potencijalne primjene u klinici.]]></summary_hr><summary_en><![CDATA[The Hedgehog signaling pathway has been implicated in development of various tumors, but the exact roles and molecular mechanisms are still not understood. The focus of this research are the tumors harboring BRAF of NRAS mutations, and their differential response to Hedgehog pathway inhibition. Both BRAF and NRAS non-canonically activate the three GLI proteins, but the activity and interplay of this interaction in still unclear. With this project we propose to determine the exact transcriptional targets of GLI1, GLI2 and GLI3 proteins in melanoma with different genetic backrounds, either harboring a BRAF mutation, a NRAS mutation, or no mutation in these two genes. For this purpose, we will first perform ChIP-seq to determine the transcriptional targets, then knock-out each of the three GLI proteins and sequence the transcriptomes of the knock-out cell lines. After the knock-outs have been generated, a series of cell assays will be performed to determine to role of each of the three GLI proteins in BRAF/NRAS dependant tumors, and to elucidate the mechanism of their action in melanoma. Combined treatments with Hedgehog inhibitors and specific BRAF/NRAS inhibitors, followed by generation and testing of resistant cell lines, will demonstrate if there is a potential benefit in the clinical management of melanoma. All these analyses will demonstrate whether GLI proteins or their transcriptional targets can be used as potential biomarkers for melanoma. Finally, in the final year of the project, a set of clinical samples will be analyzed for these potential biomarkers to determine their possible use in the clinic. In summary, this project plans a complete analysis of the GLI code in BRAF/NRAS dependant melanoma, from determining the transcriptional targets and finding molecular mechanisms, to potential translation to the clinic.]]></summary_en></project><project>
<id>8001</id><title_hr><![CDATA[Mikrosatelitna nestabilnost (MSI i EMAST) u molekularnom profiliranju sporadičnih karcinoma debelog crijeva]]></title_hr><title_en><![CDATA[]]></title_en><user_id>12624</user_id><user_firstLast_name>Tamara Čačev</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-6042</code><acronim><![CDATA[MSIandEMASTinCRC]]></acronim><duration>08.05.2019 - 07.11.2023</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>26763</team_members_id><team_members_names><![CDATA[ Doktorand: Anamarija Salar ]]></team_members_names><keywords_hr><![CDATA[karcinom debelog crijeva, mikrosatelitna nestabilnost, MSI, EMAST, NLRP3, molekularno profiliranje]]></keywords_hr><keywords_en><![CDATA[colon cancer, microsatellite instability, MSI, EMAST, NLRP3, molecular profiling]]></keywords_en><summary_hr><![CDATA[Zloćudni tumori predstavljaju jedan od vodećih zdravstvenih problema u svijetu. Karcinom debelog crijeva je jedan od najčešćih zloćudnih tumora i jedan od vodećih uzroka smrti od raka u zemljama razvijenog svijeta. Najveći broj karcinoma debelog crijeva javlja se u sporadičnom obliku, a nastaje kao posljedica stupnjevitog procesa tijekom kojeg kao posljedica stečenih mutacija nastaje zloćudni invazivni tumor. Poznato je da mikrosatelitna nestabilnost (MSI) kao i mikroRNA (miRNA) koje reguliraju ekspresiju gena također imaju ulogu u tumorigenezi ovog tumora. EMAST (od engl. Elevated Microsatellite Alterations at Selected Tetranucleotide repeats) je oblik mikrosatelitne nestabilnosti čiji je nastanak potaknut upalom, a koji utječe na napredovanje tumorske bolesti. Rezultati naših prijašnjih istraživanja ukazuju na ulogu upalnih citokina u tumorigenezi karcinoma debelog crijeva. Ovim ćemo projektom istraživanja proširiti na inflamasom NLRP3 za kojeg je pokazano da utječe na tumorigenezu s upalom povezanih gastrointestinalnih tumora. Cilj ovog projekta je ispitati mikrosatelitnu nestabilnost tipa MSI i EMAST u sporadičnim karcinomima debelog crijeva te rezultate korelirati s kliničko-patološkim karakteristikama tumora i oboljelih. Tumore ćemo molekularno profilirati s obzirom na učestalost i distribuciju MSI i EMAST te mutacija u genima koji kodiraju molekule ključnih signalnih puteva (KRAS/BRAF, p53). Rezultati će također biti korelirani s naslijeđenim genetskim profilima oboljelih temeljenim na polimorfizmima inflamasoma NLRP3 i citokina kao i s ekspresijom gena od interesa na razini mRNA, miRNA i proteina. Očekujemo da će rezultati istraživanja doprinjeti rasvjetljavanju molekularne osnove sporadičnih karcinoma debelog crijeva, te naći primjenu u praćenju i liječenju oboljelih.]]></summary_hr><summary_en><![CDATA[Cancer is one of the most important health issues of today and number of cancer cases is expected to increase in the future. Colon cancer is one of the most common cancers and the second leading cause of cancer death in the Western world. Most cases of colon cancer occur in sporadic form and follow the adenoma-carcinoma sequence. The development of the sporadic colon cancer is a result of the accumulation of sporadic mutations in many different genes, oncogenes, tumor suppressor genes as well as mismatch repair genes. It is known that microsatellite instability (MSI) as well as microRNAs (miRNAs) as regulators of gene expression also have a role in sporadic CRC tumorigenesis. Elevated microsatellite alterations at selected tetranucleotide repeats (EMAST) is a form of microsatellite instability that is initiated by inflammation and modulates colon cancer progression. The results of our previous study suggest the role of inflammatory cytokines in colon cancer tumorigenesis. In this project the research will be extended to NLRP3 inflammasome, a potent inducer of proinflammatory cytokines. The main goal of this project is to investigate MSI and EMAST microsatellite instability in sporadic colon cancer and to correlate the obtained results with clinico-pathological characteristics of tumors and patients. Tumors will be molecularly profiled with regard to frequency and distribution of MSI and EMAST and mutations in key cancer pathways (KRAS/BRAF, p53). In addition results will be correlated with patients’ inherited genetic profiles based on inflammasome NLRP3 and cytokine polymorphisms as well as expression of specific genes on mRNA, miRNA and protein level. We expect that our results will contribute to the elucidation of molecular basis of sporadic colon cancer, and be useful in patients’ surveillance and treatment.]]></summary_en></project><project>
<id>8002</id><title_hr><![CDATA[Notch signaling in osteoclast progenitors induced by rheumatoid arthritis]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3075</user_id><user_firstLast_name>Danka Grčević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-4276</code><acronim><![CDATA[NORA]]></acronim><duration>06.05.2019 - 05.08.2023</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>26491</team_members_id><team_members_names><![CDATA[ Doktorand: Masa Filipovic Filipovic ]]></team_members_names><keywords_hr><![CDATA[osteoclasts, arthritis, Notch, inflammation, progenitors, differentiation, cytokines, chemokines]]></keywords_hr><keywords_en><![CDATA[osteoklasti, artritis, Notch, upala, progenitori, diferencijacija, citokini, kemokini]]></keywords_en><summary_hr><![CDATA[Reumatoidni artritis karakteriziran je kroničnim upalnim odgovorom uz periartikularni i sustavni gubitak kosti uzrokovan pojačanom koštanom razgradnjom osteoklastima. S incidencijom od oko 1%, predstavlja značajan javnozdravstveni problem i pridonosi smanjenju kvalitete života. Osteokasti su velike multinuklearne stanice koje razgrađuju kost , a nastaju iz hematopoetskih stanica monocitno/makrofagne loze. Novije studije upućuju na moguću ulogu Notch signalnog puta u proliferaciji, diferencijaciji i migraciji stanica osteolastne loze. Međutim, točan mehanizam kako Notch signalni put djeluje u kontekstu artritisa nije poznat. Glavni cilj predloženog projekta je definirati ulogu Noch signalnog puta u proliferaciji, migraciji i diferencijaciji osteoklastnih progenitora u artritisu te testirati ima li manipulacija Notch signalnog puta učinak na aktivnost osteoklastnih progenitora i osteoresortivni potencijal.Korištenjem modela mišjeg artritisa izazvanog kolagenom (CIA) i uzoraka bolesnika s artritisom, cilj nam je razumjeti izražaj komponenti Notch sustava u pojedinim fazama tijekom diferencijacije osteoklasta i promjene izazvane artritisom, te učinke Notch-liganda na aktivnost osteoklastnih progenitora. Nadalje, planiramo testirati učinak inhibicije Notcha na proliferaciju, migraciju i diferencijaciju osteoklastnih progenitora in vitro. Kao in vivo model, primijenit ćemo neutralizacijska protutijela protiv Notcha i CreERT2 transgenične miševe u kojim će Notch signal biti inhibiran selektivno u osteoklastnim progenitorima koji izražavaju CX3CR1.Mišji CIA-model omogućit će praćenje i modulaciju razvoja bolesti uzrokovane pojačanom koštanom resorpcijom in vivo, dok će analiza ljudskih uzoraka omogućiti translaciju u kliničke uvjete. Karakterizacija Noch-signalnog puta u osteoklastnim progenitorima potaknutim artritisom pruža mogućnost razvoja terapijskih pristupa kojima će se kontrolirati njihova aktivnost, smanjujući time koštanu destrukciju uzorkovanu artritisom. ]]></summary_hr><summary_en><![CDATA[Rheumatoid arthritis (RA) is characterized by chronic inflammatory response as well as periarticular and generalized bone loss due to enhanced bone resorption by osteoclasts. With a prevalence of around 1%, it is an important contributor to public health burden and lower quality of life. Osteoclasts are large multinucleated bone-resorbing cells arising from monocyte/macrophage hematopoietic lineage. Recent evidences suggest the possible role of Notch signaling pathway in proliferation, differentiation and migration of osteoclast lineage cells. However, exact mechanism of how the Notch signaling works in the context of arthritis is largely unclear.The main goal of project proposal is to define the role of Notch signaling in osteoclast progenitor (OCP) proliferation, migration and differentiation in arthritis and to test if manipulation of Notch signaling has the effect on OCP activity and bone resorbing potential. Using the approach of mouse model of collagen-induced arthritis (CIA) and samples from arthritic patients, we aim to understand the stage specific expression of Notch system components during osteoclast differentiation and changes associated with arthritis, as well as the effects of Notch ligands on OCP activity. Furthermore, we plan to test the effect of Notch inhibition on OCP proliferation, migration and differentiation in vitro. As the in vivo model, we will utilize Notch inhibition by neutralizing antibodies and CreERT2 transgenic mouse model in which Notch signal is inhibited by tamoxifen injection selectively in CX3CR1-expressing OCPs.The mouse CIA model will enable us to monitor and modulate disease progression in the context of increased osteoresortion in vivo whereas the analysis of human samples will allow for the translation to the clinical settings. Characterization of Notch signaling in OCPs induced by arthritis could offer the potential to design therapeutic approaches to control their activity thus limiting bone destruction in arthritis.]]></summary_en></project><project>
<id>8003</id><title_hr><![CDATA[Aminoacil-tRNA-sintetaze kao čuvari standardnog genetičkog koda]]></title_hr><title_en><![CDATA[]]></title_en><user_id>20081</user_id><user_firstLast_name>Jasmina Rokov Plavec</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-1578</code><acronim><![CDATA[AARSCODE]]></acronim><duration>10.06.2019 - 09.03.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>27538</team_members_id><team_members_names><![CDATA[ Doktorand: Valentina Ević ]]></team_members_names><keywords_hr><![CDATA[aminoacil-tRNA-sintetaze, biosinteza proteina, kontrolni mehanizmi u translaciji, norvalin, sintetske aminokiseline, editing]]></keywords_hr><keywords_en><![CDATA[aminoacyl-tRNA synthetases, protein biosynthesis, translational quality control, norvaline, synthetic amino acids, editing]]></keywords_en><summary_hr><![CDATA[Genetički kod definira zakonitosti koje omogućavaju prevođenje genetičke informacije u funkcionalne molekule proteina. Suodnos kodona i aminokiseline ostvaruje se pomoću aminoacil-tRNA-sintetaza (aaRS), enzima koji sparuju aminokiselinu s pripadnom molekulom tRNA. Visok stupanj točnosti u translaciji osigurava se dijelom kroz korektivne mehanizme enzima aaRS. Učestalost mistranslacije predstavlja važno pitanje u temeljnim istraživanjima i njihovoj primjeni u medicini i biotehnologiji. Korektivni mehanizmi također djeluju kao čuvari standardnog genetičkog koda i sprječavaju ugradnju prirodnih aminokiselina koje nisu definirane genetičkim kodom. Ti mehanizmi, s druge strane, mogu otežati ugradnju sintetskih aminokiselina u dizajnerske proteine.U sklopu projekta predlaže se istraživanje sintetskih i korektivnih mehanizama enzima koji omogućuju ugradnju leucina, valina i izoleucina u proteine. Usporedit ćemo katalitičke principe i specifičnost sintetskog i korektivnog mjesta tih enzima prema proteinogenim aminokiselinama i onima koje nisu kodirane genetičkim kodom. Također, istražit ćemo toksičnost mistranslacije i stanični odgovor na izazvani stres. Cilj je razumjeti principe koji definiraju odabir standardne aminokiselinske abecede te kako narušavanje genetičkog koda utječe na staničnu fiziologiju. Navedene spoznaje olakšat će usmjerenu ugradnju fluoriranih aminokiselina u dizajnerske proteine. Konačno, testirat ćemo postojanje sprege između točnosti translacije i adaptacije na stres izazvan okolišnim uvjetima.Ovo istraživanje, kroz redizajniranje suodnosa kodona i aminokiseline, nalazi se na granici biokemije i kemijske biologije. Atraktivnost i izvedivost predloženog istraživanja uočljiva je kroz suradnje naše grupe, značajno prepoznate u polju biosinteze proteina, s istaknutim internacionalnim (Prof. Budiša, TU Berlin, Prof. Anderluh, NIC, Ljubljana, Prof. Maček, Proteome Center Tübingen) i domaćim (Dr. Vianello, IRB, Zagreb) partnerima. ]]></summary_hr><summary_en><![CDATA[The genetic code provides the basis for translation of genetic information into functional proteins. Codon assignments are established by aminoacyl-tRNA synthetases (aaRS), which couple amino acids to their cognate tRNAs. Mistakes in translation are generally kept low, in part by inherent aaRS hydrolytic editing. The extent to which mistranslation occurs presents a fundamental question in basic research with impact on medicine and biotechnology. AaRS quality control mechanisms also act as gatekeepers of the standard genetic code and prevent infiltration of natural but non-coded amino acids. Consequently, they present an obstacle for synthetic amino acid translation in rational protein design.Here we propose to investigate the synthetic and editing mechanisms of three aaRSs responsible for translation of amino acids that build the protein core: leucine, valine and isoleucine. We will compare the catalytic principles and gained specificity of the enzymes’ synthetic and editing sites against proteinogenic and non-coded amino acids. The cellular toxicity and stress responses of induced non-canonical mistranslation will be addressed. The goal is to improve our understanding of the basis for selection of the natural amino acid alphabet, and how violation of the coding principles influences cell physiology. Mechanistic insight will extend our ability to apply fluorinated amino acids in protein rational design. A possible link between altered translational fidelity and adaptation to environmental stress will be sought. This research couples biochemistry and chemical biology through the interest in reassignment of the genetic code. The assembled expertise through the international (Prof. Budiša, TU Berlin, Prof. Anderluh, NIC, Ljubljana, and Prof. Maček, Proteome Center Tübingen) and national (Dr. Vianello, RBI, Zagreb) collaborators will strongly enhance the capacity of our group, which is well-recognized in the field of protein translation, to conduct this research.]]></summary_en></project><project>
<id>8004</id><title_hr><![CDATA[Izračun antropometrijskih mjera pametnim telefonom i tabletom]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6456</user_id><user_firstLast_name>Tomislav Pribanić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-9800</code><acronim><![CDATA[STEAM]]></acronim><duration>15.07.2019 - 14.07.2023</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>27996</team_members_id><team_members_names><![CDATA[ Doktorand: Kristijan Bartol Bartol ]]></team_members_names><keywords_hr><![CDATA[3D skeniranja tijela, antropometrija, 3D antropometrijski podaci, ljudska postura, karakteristične točke tijela, tablet,pametni telefon, računalni vid]]></keywords_hr><keywords_en><![CDATA[3D body scan measurement, anthropometry, 3D anthropometric data, human posture, body landmark detection, tablet, smartphone, computer vision]]></keywords_en><summary_hr><![CDATA[Izrada 3D modela iz fotografija je jedna od glavnih zadaća računalnog vida, grane umjetne inteligencije u području računalne znanosti koja istražuje metodologiju izdvajanja informacija iz digitalnih slika. Dobivanje kvalitetnih 3D modela više nije ograničeno na obradu i istraživanje korištenjem stolnih računala i/ili prijenosnih računala visokih performansi. Moderni i moćni pametni telefoni te tableti (mobilne platforme) također otvaraju mogućnosti definiranja novih metoda za 3D rekonstrukciju. Dotično istraživanje ima dva glavna dijela. Prvi dio odnosi se na razvoj i implementaciju učinkovitih 3D algoritama rekonstrukcije optimiranih za posebnosti mobilnih platformi. Proširivanje funkcionalnosti pametnog telefona ili tableta prema 3D uređaju za skeniranje je značajno ne samo s gledišta znanstvenog istraživanja već i za potencijalnu industrijsku primjenu (ekonomsko iskorištavanje). Stoga je drugi dio ovog rada usmjeren na procjenu antropometrijskih veličina uporabom 2D i 3D podataka s mobilnih platformi. Antropometrijska mjerenja su od velikog značaja širokoj skupini korisnika jer antropometrija danas igra važnu ulogu u industrijskom dizajnu, dizajnu odjeće, ergonomiji, medicini i arhitekturi gdje se statistički podaci o raspodjeli dimenzija tijela u populaciji koriste za optimizaciju različitih proizvoda i usluga.]]></summary_hr><summary_en><![CDATA[The generation of 3D models from still images has been a long term goal in computer vision, a branch of artificial intelligence in the field of computer science which explores the state machines and models for extracting information from the digital images. Acquiring high quality 3D models is no longer restricted to processing on desktop computers and high end laptops. Modern and powerful smartphones and tablets (mobile platforms) open up the possibilities designing new methods for 3D reconstruction. The scope of this work is twofold. First part concerns the development and implementation of the efficient 3D reconstruction algorithms optimized for the mobile platforms features. Extending smartphone or tablet functionality towards 3D scanning device is interesting both for the scientific research and for the industrial (economic) exploitation as well. Therefore, the second part of this work is aimed at estimation of anthropometric measurements combining 2D and 3D data from mobile platforms. Anthropometric measurements are of particular interest to a large group of beneficiaries since nowadays anthropometry plays an important role in industrial design, clothing design, ergonomics, medicine and architecture where statistical data about the distribution of body dimensions in the population are used to optimize various products and services.]]></summary_en></project><project>
<id>8005</id><title_hr><![CDATA[Identifikacija interaktoma paralognih proteina SSB u višestaničnom prokariotu, Streptomyces coelicolor ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5923</user_id><user_firstLast_name>Dušica Vujaklija</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-5563</code><acronim><![CDATA[id_ROBUST]]></acronim><duration>10.06.2019 - 09.04.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>28732</team_members_id><team_members_names><![CDATA[ Doktorand: Goran Pipalović ]]></team_members_names><keywords_hr><![CDATA[Interaktom, paralozi proteina SSB, Streptomyces, DNA metabolizam, sinteza antibiotika]]></keywords_hr><keywords_en><![CDATA[Interactome, paralogous SSB, Streptomyces, DNA metabolism, antibiotic synthesis ]]></keywords_en><summary_hr><![CDATA[Streptomiceti su bakterije poznate po proizvodnji važnih antibiotika te složenom životnom ciklusu. U svim domenama života, proteini SSB koji vežu jednolančanu DNA imaju ključnu ulogu u replikaciji, popravku i rekombinaciji DNA. Različite bakterijske vrste imaju više paraloga SSB-a, no njihova biološka uloga je slabo istražena. Naši rezultati su pokazali kako su paralozi SSB bakterije S. coelicolor evoluirali te poprimili različite stanične funkcije. SsbA je nužan za preživljavanje, dok SsbB ima ključnu ulogu u segregaciji kromosoma tijekom sporulacije. Nedavno smo uočili da delecija gena ssbB kod određenog mutanta S. coelicolor pojačava proizvodnju antibiotika. U svrhu boljeg razumijevanja bioloških funkcija proteina SSB, cilj ovog projekta je identifikacija ineraktoma paralognih proteina SSB, analiza domene/motiva odgovornih za interakcije, te rasvjetljavanje uloge disulfidnih mostova za funkciju proteina SsbB. Najinteresantniji partneri SSB-a koji će se identificirani B2H i TAP tehnologijama,  dodatno će se analizirati raznim in vivo i in vitro tehnikama. Konstruirat ćemo, te morfološki i fenotipski okarakterizirati jednostruke i dvostruke mutante streptomiceta kojima nedostaje gen za sintezu interaktanta i gen ssbB. Kolokalizacija SSB-a i odabranih partnera ispitat će se fluorescencijskom mikroskopijom. Mehanizam vezanja proteina SSB i partnera istražit će se primjenom raznovrsnih metoda za određivanje afiniteta vezanja, poput polukvantitativnih metoda (EMSA), spektroskopskih tehnika (CD, fluorescencija, MST) i kalorimetrijskih tehnika (npr. ITC). Komparativnom proteomskom analizom istražit će se vremenska dinamika sinteze SsbB-a i njegovih partnera tijekom rane log faze i faze programirane stanične smrti kod S. coelicolor i S. rimosus s povećanom sintezom antibiotika. Pretpostavljaući da je većina partnera SsbB-a sačuvana kod streptomiceta, predložena analiza mogla bi otkriti i vremenski-ovisne SSB interakcije, potencijalno važne za sintezu antibiotika.  ]]></summary_hr><summary_en><![CDATA[Streptomycetes are best known as producers of clinically important antibiotics and for their complex life cycle. Single-strand DNA-binding (SSB) proteins have a key role in DNA replication, repair and recombination in all domains of life. Various bacteria possess paralogous SSBs, but their biological role is poorly understood. We reported that two S. coelicolor SSBs have adopted different cellular functions through evolution. While SsbA is indispensable for survival, SsbB has a key role in chromosome segregation during spore formation. Recently, we found that a specific mutant with deleted ssbB increases antibiotic production. To get a better insight into biological functions of paralogous SSB proteins, this project aims to identify SSB-interactomes, to analyse their binding domains and to elucidate the importance of disulphide bridges for SsbB functionality. Once identified by B2H system or TAP technology, the most promising interactants will be analysed by applying in vivo and in vitro techniques. Genetic constructs carrying mutations in gene encoding protein partner (if not essential) or double mutants with ssbB gene will be examined phenotypically and morphologically. The co-localization of selected SSB partners will be examined by fluorescence microscopy. To obtain information on the binding mechanisms of SSB-protein interactions, the affinity of the interacting proteins will be analysed by several approaches, such as semi-quantitative assays (EMSA), spectroscopic techniques (CD, fluorescence, MST), and calorimetric techniques like ITC. Comparative proteomic analysis will be applied to examine temporal synthesis of SsbB and its protein partners during early log and programmed cell death stage of growth in S. coelicolor and S. rimosus with elevated antibiotic production. Expecting that most of the SSB partners are conserved in Streptomyces spp., proposed analyses could uncover time-specific interaction, potentially important for antibiotic production. ]]></summary_en></project><project>
<id>8006</id><title_hr><![CDATA[Otvorene Inovacije - traslacijsko istraživanje  i razmjena znanja kroz suradnju  sveučilišta i gospdarstva Open Innovation – Research Translation and Applied Knowledge Exchange in Practice through UniversityIndustry-Cooperation]]></title_hr><title_en><![CDATA[]]></title_en><user_id>392</user_id><user_firstLast_name>Marina Dabic</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-5658</code><acronim><![CDATA[]]></acronim><duration>27.03.2019 - 26.09.2023</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, </scie_field_hr><scie_field_en>Economy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Ekonomski fakultet u Zagrebu]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Economics and Business]]></institution_en><team_members_id>27153</team_members_id><team_members_names><![CDATA[ Doktorand: Tena Obradović ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>8007</id><title_hr><![CDATA[Hidrotermalna sinteza dopiranog cerij oksidnog nanokatalizatora]]></title_hr><title_en><![CDATA[]]></title_en><user_id>2766</user_id><user_firstLast_name>Stanislav Kurajica</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-5807</code><acronim><![CDATA[HOuDiNI]]></acronim><duration>11.02.2019 - 23.09.2024</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Temeljne tehničke znanosti, </scie_field_hr><scie_field_en>Basic engineering sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet kemijskog inženjerstva i tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Chemical Engineering and Technology]]></institution_en><team_members_id>28679</team_members_id><team_members_names><![CDATA[ Doktorand: Ivana Katarina Munda ]]></team_members_names><keywords_hr><![CDATA[cerijev oksid, hidrotermalna sinteza, dopanti, katalitička aktivnost, termička stabilnost]]></keywords_hr><keywords_en><![CDATA[ceria, hydrothermal synthesis, dopants, catalytic activity, thermal stability]]></keywords_en><summary_hr><![CDATA[Hidrotermalnom sintezom bit će pripravljene dopirane nanočestice cerijeva oksida namijenjene uporabi kao heterogeni katalizator za uklanjanje hlapivih organskih spojeva. Ključna značajka cerijeva oksida je njegova sposobnost reverzibilnog redoks procesa čime se omogućava stvaranje vakancija kisika, velika pokretljivost kisika i kapacitet skladištenja kisika unutar kristalne rešetke. Takva svojstva čine cerijev oksid široko korištenim heterogenim katalizatorom.Jedna od metoda sinteze nanočestica cerijeva oksida je hidrotermalna sinteza budući da posjeduje brojne prednosti kao što su jednostavnost, dostupnost i ekološka neškodljivost te omogućuje pripremu nanočestica visoke čistoće, željene veličine, morfologije i velike površine.Uvođenje defekata u kristalnu rešetku cerijeva oksida ugradnjom metalnih iona daje cerijevom oksidu poboljšana svojstva. Stoga će se provesti sustavna studija uzoraka cerijeva oksida dopiranog ionima prijelaznih metala (Mn, Fe, Co, Ni, Cu i Zn) priravljenih pomoću hidrotermalne sinteze, kako bi se istražila sposobnost prijelaznih metala da uđu u kristalnu rešetku cerijeva oksida u uvjetima hidrotermalne sinteze, toplinska stabilnost pripremljenih katalizatora i njihova katalitička aktivnost u procesu oksidacije modelnog spoja. Na temelju dobivenih rezultata odabrat će se dva dopanta, najvjerojatnije bakar i mangan, a cerijev oksid dopiran ovim elementima bit će temeljito istražen. Pored strukture, mikrostrukture, fizikalnih svojstava i katalitičke aktivnosti, posebna pozornost bit će posvećena stabilizaciji veličine kristala i specifične površine cerijeva oksida pri povišenim temperaturama. Istraživanje će omogućiti stjecanje novih znanja o dopiranom cerijevom oksidu pripremljenom hidrotermalnom sintezom. Dodatno, očekuju se značajni rezultati na području kinetike rasta zrna i uporabe kinetičke analize za procjenu stabilnosti veličine kristala i specifične površine nanokatalizatora na povišenim temperaturama.]]></summary_hr><summary_en><![CDATA[Doped ceria nanoparticles, aimed to be used as heterogeneous catalyst for elimination of volatile organic compounds, will be prepared using hydrothermal synthesis.A key feature of ceria is its capability of reversible redox process enabling the creation of oxygen vacancies, high oxygen mobility and oxygen storage capacity within the crystal lattice. Such properties make ceria extensively used as heterogeneous catalysts. One of the synthesis methods of choice for the preparation of ceria nanoparticles is the hydrothermal synthesis, since it possesses numerous advantages such as simplicity, affordability and environmental benignity, and it enables the preparation of high purity nanoparticles of desired size, morphology and large surface area. The introduction of defects by incorporation of metal ions into ceria crystal lattice yields with enhanced properties of ceria. Therefore a systematic study of transition metals (Mn, Fe, Co, Ni, Cu i Zn) doped ceria prepared using the hydrothermal synthesis will be conducted in order to investigate the ability of transition metals to enter the ceria crystal lattice under hydrothermal synthesis conditions, thermal stability of prepared catalysts, and their catalytic activity for oxidation of model compound. On the basis of obtained results two dopant elements, most probably copper and manganese, will be selected and ceria doped with these elements should be thoroughly investigated. Beside structure, microstructure, physical properties and catalytic activity, special attention will be paid to the stabilization of crystal size and specific surface area of ceria under elevated temperatures. The investigation will enable the gain of new knowledge on doped ceria prepared by hydrothermal synthesis. Additionally, significant results are expected in the area of grain growth kinetics and its use for the estimation of nanocatalyst crystal size and specific surface area stability at elevated temperatures. ]]></summary_en></project><project>
<id>8008</id><title_hr><![CDATA[NUMERIČKI EFIKASNI RAČUNALNI ALGORITMI ZA UGRADBENE MULTI-FIZIKALNE SUSTAVE U VEKTORSKIM PROSTORIMA I NA MNOGOSTRUKOSTIMA]]></title_hr><title_en><![CDATA[]]></title_en><user_id>7734</user_id><user_firstLast_name>Zdravko  Terze</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-3465</code><acronim><![CDATA[NUMECA4EMBEDDED]]></acronim><duration>15.03.2019 - 12.02.2023</duration><status>Završio</status><financ_value>5,97 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Zrakoplovstvo, raketna i svemirska tehnika, </scie_field_hr><scie_field_en>Aerospace, missile and space engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>28668</team_members_id><team_members_names><![CDATA[ Doktorand: Marko Kasalo ]]></team_members_names><keywords_hr><![CDATA[geometrijska integracija, računanje u stvarnom vremenu, ugradbeni sustav, redukcija modela, sustav više tijela, interakcija fluida i strukture]]></keywords_hr><keywords_en><![CDATA[geometric integration, real-time simulation, embedded system, model reduction, multibody system, fluid-structure interaction]]></keywords_en><summary_hr><![CDATA[Razvoj numerički efikasnih simulacijskih modela za rad u stvarnom vremenu predmet je velikog interesa istraživača tijekom poslijednjih godina. S obzirom na stalni razvoj suvremenih tehnologija temeljenim na primjeni sve složenijih ugradbenih sustava, povećale su se i potrebe za simulacijskim modelima takvih složenih objekata, pri čemu se dinamika različitih multi-fizikalnih modela simulira unutar zajedničkog algoritma u stvarnom vremenu. Za razliku od jednostavnijih mehaničkih sustava, čije se procesiranje u stvarnom vremenu može postići konvencionalnim računalnim metodama, spregnuti multi-fizikalni sustavi zahtjevaju napredne algoritme koji su predmet intenzivnih istraživanja.Tijekom ovog projekta, uz standardne računalne formulacije u vektorskim prostorima, istražit će se i geometrijski numerički algoritmi na mnogostrukostima i Lievim grupama u svrhu razvoja numerički efikasnih simulacijskih procedura za multi-fizikalne ugradbene sustave. Posebna zadaća će se posvetiti ciljem vođenim zadaćama redukcije spregnutih modela, geometrijskim integracijskim algoritmima koji održavaju diferencijalno-geometrijsku strukturu dinamike spregnutih sustava, efikasne implementacije na specifičnom hardveru. Kada god je to opravdano, provest će se usporedba novorazvijenih geometrijskih numeričkih procedura s konvencionalnim formulacijama u vektorskim prostorima, a posebno u području redukcije multi-fizikalnih modela i optimiranih integracijskih procedura. Nakon odabira najprikladnijih algoritama, projektom će se istražiti prikladni hardver za ciljem vođene platformske (‘on-line’) računalne simulacije dinamike ugradbenih sustava. U toj fazi istraživanja, odabrat će se prikladna programska paradigma za novorazvijene algoritme i numerički eksperimenti. Poslijednja faza projekta obuhvatit će dizajn eksperimentalnih postava za odabrane multi-fizikalne ugradbene sustave s ciljem validacije numeričke efikasnosti, upravljivosti i stabilnosti novorazvijenih računalnih algoritama i procedura.]]></summary_hr><summary_en><![CDATA[Development of the numerically efficient simulation models capable of running in real-time has been a particular focus for researchers and industrial developers during the last decade. With the constant developments in the field of embedded systems, the demand for real-time simulation models of complex mechanical systems, where dynamics of different multi-physical models needs to be co-simulated within the same framework, became even larger. While conventional modelling techniques are suitable for simulating simpler tasks, coupled mechanical systems require more advanced techniques than those still being used.In this project, geometric numerical algorithms formulated on manifolds and Lie groups, as well as standard vector space formalisms, will be investigated in order to design efficient simulation procedures for multi-physical dynamics of the embedded systems. To this end, special attention will be devoted to the issues such as objective-based model reduction, structure preserving integration schemes, efficient numerical techniques and hardware-oriented code implementation. Whenever justified, novel differential-geometric computational procedures will be numerically tested against the standard vector space formalisms, especially in the context of the multi-physics model reduction and optimized integration schemes. Once the most appropriate computational models and numerical algorithms are selected during off-line simulations of the real-time dynamical processes, the project will focus on investigation of the suitable hardware platforms for the objective-based on-board simulations. This step also includes selection of the programming paradigm for the selected algorithms, as well as numerical tests. Within the last phase, the experimental implementation, comprising building of the testbed for the selected multi-physical embedded systems will be conducted in order to validate the numerical efficiency, controllability, and stability of the overall installations.]]></summary_en></project><project>
<id>8009</id><title_hr><![CDATA[Modeli i inverzne metode za elektromagnetske senzore u bliskom polju]]></title_hr><title_en><![CDATA[]]></title_en><user_id>12596</user_id><user_firstLast_name>Darko Vasić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-9574</code><acronim><![CDATA[MIMES]]></acronim><duration>15.04.2019 - 14.04.2023</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>28628</team_members_id><team_members_names><![CDATA[ Doktorand: Ivan Rep ]]></team_members_names><keywords_hr><![CDATA[senzori, elektronički sustavi, ugrađeni računalni sustav, inverzni problemi, elektromagnetski modeli, EM polje, blisko polje, nerazorno ispitivanje]]></keywords_hr><keywords_en><![CDATA[sensors, electronic systems, embedded systems, inverse problems, electromagnetic modelling, EM field, near field, nondestructive testing]]></keywords_en><summary_hr><![CDATA[Elektromagnetski senzori s radnim područjem u bliskom polju (eng. near field electromagnetic sensors, NFEMS) se temelje na promjenama električnog i magnetskog polja uslijed promjena u svojstvima materijala ili geometrije bliskih objekata ili procesa. NFEMS koji rade na frekvencijama do 10 MHz se mogu razvrstati prema dominantnom mehanizmu sprege na kapactivne (električna sprega) i induktivne (magnetska sprega). Aplikacije NFEMS-a su brojne zahvaljujući njihovoj neinvazivnosti, osjetljivosti, jednostavnosti i robusnosti. Uslijed rada u bliskom polju njihov najveći nedostatak je kompliciran odnos između mjerenih veličina (jakost polja, inducirani napon, impedancija) i ispitivanih svojstava (materijal, dimenzije, inkluzije i sl.). U pravilu, napredne primjene NFEMS-a zahtijevaju nepraktične računalno intenzivne inverzne procedure kako bi se dobio podatak pogodan za ljudsku upotrebu. Posljedično, aplikacije se oslanjaju na simplificirane modele za inverziju ili na ljudsku interpretaciju.Glavni cilj projekta je uspostava istraživačke grupe u području NFEMS-a uključujući senzorske tehnologije i sučelja, ugrađene računalne senzorske sustave, modeliranje i inverzne metode. U okviru projekta, istraživačka grupa će proučavati računalno efikasne modele NFEMS-a u području nerazornog ispitivanja cijevi i ispitivanja tla. Ova područja pokrivaju dva vrlo različita skupa materijala (vrlo vodljivi, magnetski i homogeni s inkluzijama, odnosno slabo vodljivi, dielektrični i heterogeni), pa će se istražiti različiti pristupi modeliranju te ekstrahirati zajedničke spoznaje. Istraživačka grupa će također proučavati inverzne metode zasnovane na razvijenim modelima te će eksperimentalno demonstrirati istraživane koncepte u dvije industrijski relevantne primjene. Radi ostvarivanja ciljeva projekta, grupa će razvijati napredna senzorska sučelja i ugrađene računalne sustave velike osjetljivosti, točnosti, raspoloživih računalnih resursa i sposobnosti za rad u otežanim uvjetima.]]></summary_hr><summary_en><![CDATA[Near field electromagnetic sensing (NFEMS) modality is based on the changes of electric and magnetic fields due to changes in material properties and geometry of nearby objects or processes. NFEMS operating below 10 MHz can be classified according to the dominant coupling as capacitive (electric coupling) and inductive (magnetic coupling) and they find their use in a vast number of sensing applications thanks to their non-intrusiveness, sensitivity, simple construction and robustness. Because of near field operation their greatest shortcoming is complicated relationships between measured quantities (field strength, induced voltage or impedance) and inspected properties (material properties, dimensions, inclusion, etc.). As a rule, advanced applications of NFEMS require impractical computationally-intensive inversion procedures to obtain human-suited information. Consequently, they rely either on simplified models for the inversion or on human interpretation.The overall objective of the project is to establish a research group in NFEMS including sensor technologies and interfaces, embedded sensor systems, modelling and inverse methods. During the project the group will study computationally efficient models for NFEMS in the domains of non-destructive testing of tubes and proximal soil sensing. These applications include two very different set of material properties (high conductive, magnetic, homogenous with small inclusions vs. low conductive, dielectric and heterogeneous) so different modelling approaches can be tested and complementary knowledge gained. The team will also study inverse methods based on the implemented models and will experimentally demonstrate the researched concepts on two industry-relevant applications. In order to accomplish the project&#39;s objectives, the group will engineer novel electromagnetic sensor interfaces and embedded systems with high performance in terms of sensitivity, accuracy, processing power and harsh environment deployment.]]></summary_en></project><project>
<id>8010</id><title_hr><![CDATA[Geokemija i zapis redoks indikatora u različitim uvjetima okoliša: prema boljem razumijevanju redoks uvjeta u prošlosti]]></title_hr><title_en><![CDATA[]]></title_en><user_id>561</user_id><user_firstLast_name>Elvira Bura-Nakić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-7990</code><acronim><![CDATA[REDOX]]></acronim><duration>12.02.2019 - 11.10.2023</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Interdisciplinarne prirodne znanosti, </scie_field_hr><scie_field_en>Interdisciplinary natural sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>28632</team_members_id><team_members_names><![CDATA[ Doktorand: Lucija Knežević ]]></team_members_names><keywords_hr><![CDATA[redoks prošlost, pokazatelj, izotopi, koncentracija, redoks vrste]]></keywords_hr><keywords_en><![CDATA[redox history, proxie&#39;s, isotopes, abundance, redox species]]></keywords_en><summary_hr><![CDATA[Rekonstrukcija kemijskog sastava atmosfere i oceana tijekom duge Zemljine geološke povijesti, kao i karakterizacija redoks uvjeta atmosfere i oceana, odnedavna privlači veliku pozornost. Oceanski sedimenti sadržavaju geokemijske zapise kroz veći dio Zemljine povijesti. Istraživanja su pokazala da faktor obogaćenja metala osjetljivih na redoks uvjete, kao i njihov izotopni sastav u (anoksičnim) sedimentima, nose važne informacije o redoks uvjetima u vremenu taloženja sedimenta. Ipak kako bi se u potpunosti iskoristile mogućnosti koje pružaju različiti pokazatelji za rekonstrukciju Zemljine redoks prošlosti obligatorno je temeljito razumijevanje ponašanja istih u suvremenim okolišima.Cilj REDOX-a je daljnja karakterizacija ponašanja prethodno istraživanih pokazatelja (Mo i U), te detaljno istraživanje relativno novih redoks pokazatelja kao što su V i Re. Kombinacija tih pokazatelja pružiti će poboljšani radni okvir nužan za što bolje tumačenje prošlih redoks uvjeta kao i za razdvajanje općih zapisa od zapisa uslijed procesa ograničenih unutar sedimenta.Istraživanja unutar projekta REDOX usmjerena su na:i.) unapređenje primjene skupne Mo-U koncentracije i izotopnih sastava kao redoks pokazatelja;ii.) razvijanje/implementacija specifičnih analitičkih postupaka za određivanje V redoks vrsta i Re izdvajanje i koncentriranje;iii.) definiranje procesa koji kontroliraju Re i V koncentraciju i mobilnost u sedimentu i vodenoj fazi u oksičnim, hipoksičnim i anoksičnim sredinama.Istraživanje unutar REDOX-a ima za cilj kombinirati specifične analitičke pristupe (kromatografsko određivanje V redoks vrsta, izolacija i koncentriranje Re), klasične analitičke tehnike (spektrofotometrija, MC-ICP-MS i elektrokemija) kao i specifičnosti jedinstvenih anoksičinih okoliša uz istočnu obalu Jadrana. Očekuje se da će istraživanja u okviru REDOX-a imati veliki utjecaj u području geokemije i izotopne geokemije metala osjetljivih na redoks (Mo, U, V i Re) unutar modernih i drevnih okruženja.]]></summary_hr><summary_en><![CDATA[Reconstructing the chemistry of past Earth’s atmosphere and ocean, and their redox states, has gained enormous attention recently. Ocean sediments provide geochemical records through much of Earth’s history. The enrichment of several redox-sensitive trace elements, as well as their isotopic composition in (anoxic) sediments have previously shown to carry important information about the prevailing redox conditions at the time of sediment deposition. Yet, to fully capitalize potential of these emerging redox proxies in reconstructing Earths’ past oxygenation state, a thorough understanding proxies geochemistry in modern environments is mandatory.   We aim to further characterise the redox chemistry on proxies which already have some maturity (Mo and U) as well targeting the newly emerging proxies such are V and Re. Combining these proxies will provide an improved framework for interpreting the specific past redox conditions and separate global ocean signatures from localised effects in the sediments. The research within project REDOX will target following subjects:i.) improve the usage of coupled Mo-U abundance and isotopic composition as redox proxy;ii.) development/implementation of specific analytical procedures for determining V redox speciation and Re concentration;iii.) determine the processes controlling Re and V abundance and mobility in sediments and overlying waters spanning oxic, hypoxic and anoxic conditions.The research within REDOX aims to combine particular analytical procedures (chromatographic redox V speciation, Re pre-concentration) with the several others classical analytical techniques (spectrophotometry, MC-ICP-MS and electrochemistry) and the unique study sites along the eastern Adriatic Coast. The research within REDOX is expected to have high impact in the field of environmental and isotope geochemistry, and will significantly contribute to our fundamental understanding of Mo, U, V and Re geochemistry within modern and ancient environments.]]></summary_en></project><project>
<id>8012</id><title_hr><![CDATA[Establishing a F-16 flight simulator with additional focus on the psycho-physical endurance of the pilot]]></title_hr><title_en><![CDATA[]]></title_en><user_id>18918</user_id><user_firstLast_name>Krešimir Ćosić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-9863</code><acronim><![CDATA[]]></acronim><duration></duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>28800</team_members_id><team_members_names><![CDATA[ Doktorand: Zvonimir Jukić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>8013</id><title_hr><![CDATA[Kontrola neurodegeneracije moduliranjem sprege između upale i proteinopatije]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4630</user_id><user_firstLast_name>Ivana Munitić </user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-7739</code><acronim><![CDATA[ImmunoModifyCNS]]></acronim><duration>04.03.2019 - 03.11.2023</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Interdisciplinarno područje znanosti</scie_area_hr><scie_area_en>Interdisciplinary scientific area</scie_area_en><scie_field_hr>Biotehnologija u biomedicini, </scie_field_hr><scie_field_en>Biotechnology in Biomedicine, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Fakultet biotehnologije i razvoja lijekova]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Biotechnology and Drug Development]]></institution_en><team_members_id>28721</team_members_id><team_members_names><![CDATA[ Doktorand: Nikolina Prtenjača ]]></team_members_names><keywords_hr><![CDATA[neuroinflamacija, neurodegeneracija, optineurin, TBK1, IFN-beta]]></keywords_hr><keywords_en><![CDATA[neuroinflammation, neurodegeneration,  optineurin, TBK1, IFN-beta]]></keywords_en><summary_hr><![CDATA[Dva obilježja zajednička svim neurodegenerativnim bolestima su kronična neuroinflammacija i proteinopatija, procesi koji se aktivno međusobno amplificiraju. Mutacije u optineurinu, adaptorskom proteinu koji regulira različite stanične funkcije poput prijenosa signala tijekom upale i autofagije, pronađene su u amiotrofičnoj lateralnoj sklerozi (ALS) i frontotemporalnoj demenciji (FTD). Da bismo istražili ulogu optineurina u neurodegeneraciji prilikom ALS/FTD-a, razvili smo mišji model u kojem smo izrezali regiju kojom veže ubiquitin, time oponašajući C-terminalne delecije pronađene u bolesnika. Zanimljivo je da su u bolesnika s ALS-om i FTD-om nedavno pronađene mutacije i u proteinskim partnerima optineurina, poput Tank binding kinaze 1 (TBK1), što sugerira da djeluju u zajedničkom neuroprotektivnom putu. Ovdje ćemo pratiti dva ključna opažanja iz naše početne karakterizacije modela Optn470T gdje smo ustanovili da nedostatak funkcionalnog optineurina umanjuje aktivnost TBK1 i produkciju IFN-ß u stanicama mikroglije i makrofaga, dovodeći do neravnoteže u proupalnim i protuupalnim čimbenicima, te da su ostarjeli Optn470T miševi razvijaju patognomonične ALS/FTD agregate u frontalnom korteksu, koji sadrže TDP-43 i ubikvitin. U ovom projektu planiramo 1) primijeniti nove CRISPR modele stanične deficijencije optineurina kako bismo razjasnili spregu između agregacije proteina i upale in vitro, te  2) manipulirati tijek bolesti u in vivo ALS/FTD modelu odabranim genetskim i virusnim metodama. Nadalje, na temelju naših rezultata da je optineurin ključni regulator imunomodulacijskog IFN-ß citokina, posebna pažnja će biti stavljena na pokušaj terapijskog apliciranja IFN-ß intratekalno pomoću genske terapije s AAV 2/9. Budući da je optineurin neuroprotektivna molekula na raskrižju upale i proteinopatije, nadamo se da ćemo točnim molekularnim razjašnjenjem njengove neuroprotektivne uloge, identificirati najprikladnije putove za terapijsku manipulaciju.]]></summary_hr><summary_en><![CDATA[Two hallmarks common to all neurodegenerative diseases are chronic neuroinflammation and proteinopathy, processes that actively amplify each other. Mutations in optineurin, an adaptor protein implicated in various cellular functions including inflammatory signalling and autophagy, have been found in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). To investigate the mechanistic role of optineurin in neurodegeneration in ALS/FTD, we have generated a mouse model in which the ubiquitin-binding region of optineurin was deleted, mimicking C-terminal truncations found in patients. Interestingly, optineurin-interacting proteins, such as Tank binding kinase 1 (TBK1), have also recently been found in ALS and FTD patients, suggesting that they participate in a shared neuroprotective pathway. Here we will follow-up two key observations from our initial characterization of the Optn470T model where we found that the lack of functional optineurin precluded optimal TBK1 activation and IFN-ß production in microglia and macrophages, leading to a disbalance in proinflammatory and anti-inflammatory factors, and that aged Optn470T mice developed pathognomonic ALS/FTD aggregates containing TDP-43 and ubiquitin in their frontal cortices. To this end, we will 1) apply novel CRISPR-generated cellular systems of optineurin deficiency to elucidate the crosstalk between protein aggregation and inflammation in vitro, and 2) manipulate the disease course in the in vivo ALS/FTD models by selected genetic and viral tools. In particular, based on our results that optineurin is a key regulator of the immunomodulatory IFN-ß pathway, a special focus will be to deliver IFN-ß intrathecally by adenovirus-associated virus 2/9 gene therapy. Overall, by addressing several outstanding questions on optineurin, a neuroprotective molecule at the crossroads of inflammation and proteinopathy, we intend to pinpoint the most likely pathway(s) for therapeutic manipulation.]]></summary_en></project><project>
<id>8014</id><title_hr><![CDATA[Razumijevanje popravka unakrsnog vezanja DNA-Protein in vivo koristeći zebricu kao istraživački model ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4272</user_id><user_firstLast_name>Marta Popović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-8636</code><acronim><![CDATA[DNAPRO]]></acronim><duration>08.05.2019 - 08.11.2023</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>27233</team_members_id><team_members_names><![CDATA[ Doktorand: Ivan Antičević ]]></team_members_names><keywords_hr><![CDATA[DNA-protein unakrsna veza, DNA oštećenja, popravak DNA, in vivo, riba zebrica]]></keywords_hr><keywords_en><![CDATA[DNA-protein crosslink, DNA damage, DNA repair, in vivo, zebrafish]]></keywords_en><summary_hr><![CDATA[Unakrsna veza DNA-protein (eng. DNA-protein crosslink; DPC) je tip DNA oštećenja koje nastaje kao posljedica ireverzibilne kovalentne veze između DNA i proteina u prisutnosti endogenog ili egzogenog DPC inducirajućeg agensa. Endogeni DPC induceri su nusprodukti staničnog metabolizma poput oksidativnih radikala, aldehida i promjene u DNA strukturi, dok su primjeri egzogenih inducera ultraljubičasto i ionizirajuće zračenje te različiti kemijski agensi. DPC-i su česta DNA oštećenja i predstavljaju fizičku prepreku za sve DNA transakcije: replikaciju, transkripciju, rekombinaciju i popravak. Nemogućnost popravka DPC-ova uzrokuje genomsku nestabilnost i teške posljedice za organizam, uključujući preuranjeno starenje, neurodegenreaciju i pojavu tumora. Unatoč visokoj učestalosti pojave DPC-a, malo se zna o mehanizmu njihova popravka, jer se sve donedavno DPC popravak nije smatrao zasebnim mehanizom popravka DNA. Tijekom 2014. i 2016. god. nekoliko grupa je identificiralo nove stanične enzime, proteaze Wss1 i SPRTN, koje proteolizom DPC-a iniciraju njihov popravak. Otkriće proteolizno-ovisnog popravka DPC-a dovelo je do prepoznavanja DPC popravka kao zasebnog mehanizma popravka DNA oštećenja. Međutim, trenutno nije poznata regulacija cijelog mehanizma, niti je poznato koji drugi faktori sudjeluju u popravku, dok gotovo ništa nije poznato o mehanizmu DPC popravka in vivo. Stoga je glavni cilj predloženog projekta otkriti regulaciju puta popravka DPC-a in vivo koristeći ribu zebricu (Danio rerio) kao istraživački model. Koristit ćemo CRISPR/Cas9 gensku manipulaciju kako bi utišali ili mutirali gen(e) od interesa, a za koji pretpostavljamo da su uključeni u DPC popravak. Uloga pojedinih proteina (i njihovih kombinacija) u popravku DPC-a biti će analizirana nakon izolacije DPC-a iz transgeničnih embrija i odraslih jedinki zebrice. Također, konstruirati ćemo GFP reporter test sa transgenim ribama koji će omogućiti kvantifikaciju učinkovitosti DPC popravka in vivo. ]]></summary_hr><summary_en><![CDATA[A DNA-protein crosslink (DPC) is a type of DNA lesion where a protein becomes irreversibly covalently bound to DNA upon exposure to endogenous or exogenous crosslink inducers. Endogenous DPC inducers are products of normal cellular metabolism such as reactive oxygen species, aldehydes and DNA helical alterations, while exogenous inducers include UV light, ionizing radiation and various chemicals. DNA-protein crosslinks are one of the most common DNA lesions and present a physical blockage to all DNA transactions: replication, transcription, recombination and repair. If not repaired, DPCs cause genomic instability and adverse phenotypes in humans including premature aging, neurodegeneration and cancer. Despite the frequency and severe outcomes of DPC formation, DNA-protein crosslink repair (DPCR) has been sparsely studied, mostly because it has not been considered to be a separate DNA damage repair pathway until recently. In 2014 and 2016, several groups identified novel proteases, Wss1 and SPRTN, which initiate the removal of DPCs through the proteolytic digestion of crosslinked proteins. The discovery of proteolysis-coupled DPC repair lead to recognition of DPCR as a separate DNA damage repair pathway. However, we currently do not know how this pathway is orchestrated and which other factors are involved. Indeed, almost nothing is known of DPCR mechanisms in vivo. Therefore, within this project we aim to unravel the orchestration of the DPCR pathway in vivo using zebrafish as a well-characterized vertebrate model. We will use CRISPR/Cas9 gene manipulation tools to knock-out and mutate specific genes in zebrafish which we suspect are involved in DPC removal. The contribution of each protein (and their combinations) to DPCR will be quantified after DPC isolation from transgenic zebrafish embryos and adults. We will also generate a GFP reporter assay in transgenic fish which will enable the quantification of DPCR efficiency in vivo.]]></summary_en></project><project>
<id>8015</id><title_hr><![CDATA[Biološka važnost dipeptidil peptidaze III i njezin utjecaj na zdravlje čovjeka              ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>2974</user_id><user_firstLast_name>Sanja Tomić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-9456</code><acronim><![CDATA[DPP3BioRe]]></acronim><duration>23.08.2019 - 23.02.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>27544</team_members_id><team_members_names><![CDATA[ Doktorand: Antonia Matić ]]></team_members_names><keywords_hr><![CDATA[metaloenzim, peptidaza, proteinske interakcije, parametri za ion cinka, vezno mjesto, inhibicija, neuropeptidi, DPP III, Keap1-Nrf2 signalni put]]></keywords_hr><keywords_en><![CDATA[metalloenzyme, peptidase, protein interaction, zinc ion parameters, binding site, inhibition, neuropeptides, DPP III, Keap1-Nrf2 signalling pathway]]></keywords_en><summary_hr><![CDATA[Poznato je da ljudska dipeptidil peptidaza III (hDPP III) in vitro katalizira hidrolizu nekih neuropeptida, te da je uključena u stanični odgovor na oksidativni stres preko Keap1-Nrf2 signalnog puta.Cilj predloženog istraživanja je proširiti znanje o biološkom značaju te cink-ovisne egzopeptidaze i njezinom utjecaju na zdravlje čovjeka. Kako bismo postigli zadani cilj, planiramo: (1) razviti nove parametre za ion cinka u proteinima i optimizirati računalne metode u istraživanju strukture metaloenzima, (2) pobliže razjasniti ulogu hDPP III u oksidativnom stresu proučavanjem njenog sudjelovanja u Keap1-Nrf2 signalnom putu, (3) proučiti vezanje nekoliko metalnih dikationa (Zn2+, Cu2+, Mn2+ i Co2+ ) za hDPP III, rasvjetliti mehanizam njihove izmjene i identificirati potencijano inhibitorno vezno mjesto metala, (4) unaprijediti saznanja o prirodnim supstratima ljudske DPP III, te (5) nastojati pronaći nove, moćne inhibitore katalitičke funkcije hDPP III.Novorazvijeni parametri bit će primjenjivi ne samo na hDPP III, već i na druge o cinku ovisne proteine sa sličnim veznim mjestom za metal. Kombinacija računalnog i eksperimentalnog (kinetičkog, spektrometrijskog, strukturalnog i termodinamičkog) pristupa donijet će nova saznanja o protein-protein (hDPP III – Keap1) i protein-ligand (hDPP III – peptidi/inhibitori) interakcijama na molekularnoj razini i njihovoj povezanosti s prijenosom signala u stanici. Ovo istraživanje trebalo bi ponuditi nove smjerove u razvoju farmakoloških spojeva s mogućnošću kontroliranja mehanizama u koje je DPP III uključena.]]></summary_hr><summary_en><![CDATA[It is known that human dipeptidyl peptidase III (hDPP III) cleaves several neuropeptides in vitro, and participates in the cellular oxidative stress response through the involvement in Keap1-Nrf2 signalling pathway. The aim of the proposed research is to advance the knowledge on biological relevance of this zinc dependent exopeptidase and its influence on human health. In order to achieve this, we plan to: (1)  develop new parameters for Zn2+ ion in proteins and optimize the computational approaches in the study of metalloenzyme structure, (2) come closer in understanding the role hDPP III has in the oxidative stress by studying its involvement in the Nrf2-Keap1 signalling pathway, (3) study the binding of several metal dications (Zn2+, Cu2+, Mn2+, and Co2+ ) to hDPP III and mechanism of their exchange, as well as to find the potential inhibitory metal binding site, (4) improve the knowledge on DPP III natural substrates in human, and (5)  search for new, potent inhibitors of the hDPP III catalytic function.The newly developed parameters will be beneficial not only for hDPP III but also for the other zinc dependent proteins with similar metal binding site. The combined computational and experimental (kinetic, spectrometric, structural and thermodynamic) approach should advance the knowledge of the molecular basis of protein-protein (hDPP III – Keap1) and protein-ligand (hDPP III – peptides/inhibitors) interactions and their implications on cell signalling. The study should suggest directions  for the development of pharmacological molecules with potential to control processes in which human DPP III participates.]]></summary_en></project><project>
<id>8016</id><title_hr><![CDATA[Science and Technology in childhood Obesity Policy]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1126</user_id><user_firstLast_name>Maroje Sorić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-8532</code><acronim><![CDATA[]]></acronim><duration>01.09.2019 - 31.08.2023</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Javno zdravstvo i zdravstvena zaštita, </scie_field_hr><scie_field_en>Public health and health services, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Kineziološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Kinesiology]]></institution_en><team_members_id>28715</team_members_id><team_members_names><![CDATA[ Doktorand: Petra Jurić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>8017</id><title_hr><![CDATA[Transormacija robota u edukacijsko sredstvo]]></title_hr><title_en><![CDATA[]]></title_en><user_id>22784</user_id><user_firstLast_name>Kristina Cergol Kovačević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-2559</code><acronim><![CDATA[TRES]]></acronim><duration>01.04.2019 - 31.03.2023</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filologija, </scie_field_hr><scie_field_en>Philology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Učiteljski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Teacher Education]]></institution_en><team_members_id>25956</team_members_id><team_members_names><![CDATA[ Doktorand: Petra Karabin ]]></team_members_names><keywords_hr><![CDATA[edukacijski robot, analitika učenja, obrada video signala, otkrivanje znanja u skupovima podataka, edukacijsko sredstvo, nastavni materijali]]></keywords_hr><keywords_en><![CDATA[educational robot, learning analytics, video processing, data mining, educational tool, learning materials]]></keywords_en><summary_hr><![CDATA[Današnji trend je korištenje velikog broja elektroničkih uređaja u razredu: pametne ploče, prezentacije, Internet, edukacijski roboti. Iz mnoštva uređaja i informacija, teško je odrediti pomažu li oni uopće u poučavanju. Mnoge aktivnosti se upravo svode na njihovo korištenje, a ne na iskorištavanje njihovih prednosti s ciljem poučavanja. Predloženi projekt će razviti metodologiju evaluacije korištenja edukacijskih robota u poučavanju osnovnoškolskih predmeta. Pri tome će se uzeti u obzir postignuta razina znanja, ali i zadovoljstvo učenika za vrijeme i nakon održanog sata. Dodatno, roboti će se koristiti za identifikaciju individualne strategije učenja svakog učenika. Na temelju razvijene metodologije i eksperimentalnih rezultata, napravit će se usporedna analiza edukacijskih robota koji postoje na tržištu. Kako bi se postigli ciljevi projekta koristit će se analitički podaci koje je moguće prikupiti iz samih robota i njihovih programskih okruženja za vrijeme njihove upotrebe. Razvit će se algoritmi obrade prikupljenih informacija, njihova analiza, evaluacija i vizualizacija. Predložit će se prototip sustava koji uključuje unaprijeđene edukacijske robote, individualnu strategiju učenja učenika i nastavne materijale, a sa ciljem postizanja maksimuma znanja i uz maksimalno ugodan proces učenja. Istraživači okupljeni u istraživačku grupu su iskusni u dizajniranju, programiranju i korištenju edukacijskih robota, u razvoju metodologije istraživanja, u radi s učenicima osnovnih škola, te u otkrivanju znanja u skupovima podataka i u razvoju metoda znanosti o podacima.]]></summary_hr><summary_en><![CDATA[Today&#39;s trend is to use a number of electronic devices during the class: smart boards, presentations, the Internet, educational robots. From a plenty of devices and information, it is difficult to determine do they help or not in teaching pupils. Many activities are just about how to use the devices, and not to exploit their strengths in the teaching process. Proposed project will develop methodology for evaluation of the usage of educational robots in teaching primary school subjects. The methodology will consider the level of knowledge as well as learners’ satisfaction during and after the lessons. Additionally, the robots will be used for identification of individual learning strategies. Based on the developed methodology and experimental results, comparison of the state-of-the-art educational robots will be made. To achieve the project goals, analytic data will be collected from the logs of the educational robots and their programming environments. Algorithms for processing of the collected data, their analysis, evaluation and visualization will be developed. Finally, a prototype of a system, that includes the improved educational robots, the individual learning strategies and teaching materials will be proposed. The aim of the prototype is to achieve the maximum of the knowledge through a satisfying learning process. Researchers gathered in the research group have experience in designing, programming and using educational robots, in developing research methodologies, in field work with pupils, and in data mining and data science methods.]]></summary_en></project><project>
<id>8018</id><title_hr><![CDATA[PC-ATE Buildings -- Razvoj sustava prediktivnog upravljanja i autonomnog trgovanja energijom u zgradi]]></title_hr><title_en><![CDATA[]]></title_en><user_id>7612</user_id><user_firstLast_name>Mario Vašak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-5161</code><acronim><![CDATA[]]></acronim><duration>02.09.2019 - 01.12.2023</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>28688</team_members_id><team_members_names><![CDATA[ Doktorand: Marko Kovačević ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>8019</id><title_hr><![CDATA[Istraživanje ravnoteže mikrobioma debelog crijeva]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5774</user_id><user_firstLast_name>Antonio Starčević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-7577</code><acronim><![CDATA[MicroEquilibrium]]></acronim><duration>06.05.2019 - 06.05.2023</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Biotehnologija, </scie_field_hr><scie_field_en>Biotechnology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Food Technology and Biotechnology]]></institution_en><team_members_id>28774</team_members_id><team_members_names><![CDATA[ Doktorand: Ema Svetličić ]]></team_members_names><keywords_hr><![CDATA[mikrobiom, bioreaktor, mikrobiota, ravnoteža, probiotik, prebiotik, pretilost, fekalni transplant, personalizacija, enterotip]]></keywords_hr><keywords_en><![CDATA[microbiome, bioreactor, microbiota, equilibrium, probiotic, prebiotic, obesity, fecal transplant, personalization, enterotype]]></keywords_en><summary_hr><![CDATA[MicroEquilibrium želi in vitro, u bioreaktoru uspostaviti i održavati dinamičku ravnotežu mikroorganizama definiranu  postojanjem pozitivne kovarijance između udjela rodova Bacteroides, Prevotella i Ruminococcus u inokulumu (fecesu) i biomasi izuzetoj nakon provedenog šaržnog uzgoja s prihranom u bioreaktoru. U tako uspostavljenom modelu ispitivati će se utjecaj niza kombinacija prebiotika i pro-lijekova na promjenu ravnoteže sa ciljem pomaka prema enterotipu karakterističnom za fenotip zdravstveno poželjnog BMI-a. Jedino interdisciplinarnim pristupom koji uključuje sistemsku biologiju,genomiku, proteomiku,bioinformatiku,kliničku medicinu,antropologiju,matematičko modeliranje i društveni izazov pretilosti moguće je istraživati problematiku kompleksnih mikrobnih zajednica našeg probavila. Prednost ovakvog pristupa jest u činjenici da se istraživanjem in vitro, može efikasno eliminirati niz čimbenika i etičkih pitanja nad kojima inače nemamo kontrolu. Potencijal rezultata koje ovo istraživanje može generirati jest u mogućnosti personalizacije terapeutika baziranih na standardiziranim i neškodljivim dodacima prehrani u vidu prebiotika i pro-lijekova gdje je efikasnost ispitana u uvjetima in vitro. Uvođenje testiranja učinkovitosti in vitro, u bioreaktoru iznad je trenutnog stanja tehnike kada su u pitanju pretilost i dodaci prehrani gdje se sve više dovodi u pitanje njihova učinkovitost pri jednoobraznoj primjeni. Odjek ovakvog interdisciplinarnog istraživanja odnosi se na društvo u cjelosti. Pretilost je postala globalni problem,a niti jedna zemlja u posljednjih 33 godine nije uspjela preokrenuti ovaj negativni trend koji uzima veliki danak kroz sve veće izdatke u javnom zdravstvu. Istraživanje dinamike ravnoteže crijevnog mikrobioma s ciljem usmjeravanja prema željenom ishodu jedan je od najperspektivnijih smjerova u koji treba uložiti istraživačke napore da se pronađu odgovarajuća rješenja kako bismo ponudili što efikasniju terapiju ovom globalnom problemu.]]></summary_hr><summary_en><![CDATA[MicroEquilibrium aims to establish and maintain dynamic equilibrium of gut microbiota in vitro. Equilibrium is defined by positive covariance between ratios of Bacteroides, Prevotella and Ruminococcus observed in donor feces and in extracted biomass after fed-batch bioreactor cultivation. This in vitro model will be utilized to test hypothesis where introducing combinations of prebiotics and ortho-silicic acid in form of zeolites during cultivation can shift the observed equilibrium in targeted direction. Targeted direction is positively correlated with genus ratios observed in volunteers having healthy BMI span. Only an interdisciplinary approach which includes system biology,genomics,proteomics, bioinformatics,medicine,anthropology and mathematcial modelling can provide us with insights into dynamics of complex microbial communities existing in our guts. Using bioreactor model instead of volunteers is an attractive possibility which removes obstacles such as lack of control and ethical issues. Greatest benefit of planned research is the possibility to translate  results into personalized therapy for obesity which targets host mibrobiota equilibrium. The fact that the efficacy of this therapy is already tested in vitro is one step above current state-of-the-art in the field. Impact of this interdisciplinary research is great since it targets a major social, medical and economical problem. Obesity is one of the leading global problems. In the last 33 years not a single country has managed to turn this negative trend which is taking it&#39;s toll in terms of growing healthcare expenses. Since current research is questioning efficacy of generic treatment of systemic conditions such as obesity with drugs and probiotics, defining and exploring the dynamic equilibrium of microbiota is a perspective research direction. This direction requires a lot if effort and this project lowers threshold by going in vitro.]]></summary_en></project><project>
<id>8020</id><title_hr><![CDATA[Višekromoforne probe za prepoznavanje pojedinih struktura DNA, RNA i proteina]]></title_hr><title_en><![CDATA[]]></title_en><user_id>480</user_id><user_firstLast_name>Ivo Piantanida</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-5977</code><acronim><![CDATA[BioMultiChromoProbes]]></acronim><duration>09.05.2019 - 09.07.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>26666</team_members_id><team_members_names><![CDATA[ Doktorand: Ivona Krošl ]]></team_members_names><keywords_hr><![CDATA[DNA, RNA, protein, fluorescencija, supramolekulsko prepoznavanje, bioaktivnost]]></keywords_hr><keywords_en><![CDATA[DNA, RNA, protein, fluorescence, supramolecular recognition, bioactivity]]></keywords_en><summary_hr><![CDATA[Molekularno prepoznavanje nukleinskih kiselina i proteina je od temeljne važnosti za život. Male molekule koje selektivno vežu specifične biomakromolekule stoga su vrlo zanimljive ne samo za razumijevanje takvih procesa već i za potencijalne medicinske primjene, kao lijekovi ili obilježavači za biooslikavanje i analitičke svrhe. U posljednjih 5 godina razvili smo u suradnji s našim partnerima niz novih fluorescentnih aminokiselina i oligopeptida koji su prepoznavali različite DNA ili RNA strukture. Također smo pokazali da se ne-kovalentna agregacija kromofora može koristiti za prepoznavanje DNA / RNA. Nedavno smo razvili inhibitore fluorescentnih enzima i nove mitohondrijske specifične fluorescentne markere. U ovom prijedlogu želimo koristiti veliku biblioteku fluorescentnih aminokiselina razvijenih u prethodnom HrZZ projektu (i pripremiti nove poboljšane), kao i naša znanja o agregaciji boja, te dizajnirati i pripremiti multikromoforne peptide s različito kombiniranim kromoforima (npr. FRET parovi) i DNA / RNA / proteinski ciljanim supstituentima. Takvi peptidni sustavi bi poslužili kao višenamjenski obilježavači za simultano obilježavanje (različitim spektrometrijskim odgovorima) nekoliko različitih sekundarnih struktura (npr. raznih ds- ili ss-DNA / RNA sekvenci, proteina). Alternativno, peptidi će biti dizajnirani za visoko selektivnu interakciju s određenim biološkim ciljem (npr. određeni ds- ili ss-DNA/RNA slijed, DPP III enzim ili amiloid-fibrilacijski peptidni slijed). Interakcija s DNA / RNA / proteinima proučavat će se UV / Vis, fluorescencijom, CD / LD spektroskopijom i DSC / ITC mikrokalorimetrijom, MS, NMR, CLSM.Prijedlog je u skladu s ciljevima HrZZ-a: a) suradnja s međunarodno dobro prepoznatim inozemnim znanstvenicima, b) osposobljavanje mladih istraživača u međunarodnom istraživačkom okruženju i c) očekivani rezultati imaju potencijal komercijalizacije kao nove biokemijski obilježavači / ili lijekovi. Troškovi projekta su 994.000,00 kn za 4 godine.]]></summary_hr><summary_en><![CDATA[Molecular recognition of nucleic acids and proteins is of fundamental importance for life. Small molecules selectively targeting specific biomacromolecules are therefore highly interesting not only for understanding of such processes but also for potential medicinal applications, as drugs or probes for bioimaging and analytical purposes. In the last 5 years we developed in collaboration with our partners a series of novel fluorescent amino acids and oligopeptides, which recognised various types of DNA or RNA structures. Also, we showed that non-covalent aggregation of chromophores could be used for DNA/RNA recognition. Very recently we developed fluorescent enzyme inhibitors and novel mitochondria-specific fluorescent markers. In this proposal we want to use large library of fluorophore-amino acids developed in previous CSF project (and prepare new improved ones), as well as our knowledge on dye aggregation, to design and build multichromophore peptides, with variously combined chromophores (e.g. in FRET pairs) and DNA/RNA/protein targeting substituents. Such peptides would serve as multi-purpose probes for the simultaneous sensing (by different spectrometric responses) of several different biomacromolecule secondary structures (e.g. various ds- or ss- DNA/RNA sequences, proteins). Alternatively, peptides will be designed for highly selective interaction with particular bio-target (e.g. particular ds- or ss- DNA, RNA, DPP III enzyme or amyloid-fibrillation peptide sequence). The interaction with DNA/RNA/proteins will be studied by UV/Vis, fluorescence, CD/LD spectroscopy and DSC/ITC microcalorimetry, MS, NMR, CLSM. Proposal addresses the most important CSF goals: a) collaboration with well-established international scientists, b) training of young researchers within the international research environment and c) the expected results have commercialisation potential as novel biochemical probes and/or drugs. Project costs are 994,000.00 HRK for 4 years.]]></summary_en></project><project>
<id>8021</id><title_hr><![CDATA[Cikloadicijske strategije prema policikličkim gvanidinima]]></title_hr><title_en><![CDATA[]]></title_en><user_id>368</user_id><user_firstLast_name>Zoran Glasovac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-6401</code><acronim><![CDATA[CycloGu]]></acronim><duration>14.05.2019 - 14.11.2023</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>28639</team_members_id><team_members_names><![CDATA[ Doktorand: Luka Barešić ]]></team_members_names><keywords_hr><![CDATA[organska sinteza, cikloadicije, gvanidini, bazičnost, kvantno-kemijski računi]]></keywords_hr><keywords_en><![CDATA[organic synthesis, cycloadditions, guanidines, basicity, quantum-chemical calculations]]></keywords_en><summary_hr><![CDATA[Znanstveni pristup projekta temelji se na kombinaciji eksperimentalnih i teorijskih istraživanja. Projekt obuhvaća organsku kemijsku sintezu, fizikalno-kemijsku karakterizaciju novih organskih molekula, kao i kvantno-kemijske proračune i molekularno modeliranje.Cilj projekta je istražiti inherentna fizikalno-kemijska svojstva (poli)cikličnih gvanidina u kojima je barem jedan atom dušika ugrađen u heterociklički prsten ili vezan za policikličke strukture. Ciljevi su: a) Sinteza (poli)cikličkih molekularnih sustava koji posjeduju gvanidinske funkcionalnosti primjenom ekološki prihvatljivih sintetskih metoda (s naglaskom na cikloadicijske rakcije) i njihovu spektroskopsku i strukturnu karakterizaciju; b) Mehanističke studije primijenjenih reakcija; c) Detaljni uvid u temeljne molekularne mehanizme kako inkorporiranje gvanidinske funkcionalnosti u cikličke strukture posreduje svojstvu superbazičnosti; d) Razvoj modelnih cikličkih gvanidinskih sustava za anionsko prepoznavanje; e) Uporaba cikličkih gvanidinskih sustava u razvoju bazne katalize.Rezultati temeljnih studija provedenih u okviru ovog projekta poboljšat će razumijevanje fizikalno-kemijskih čimbenika koji upravljaju superbazičnosti u cikličkim sustavima i unaprijediti njihov dizajn. Očekivani rezultati omogućuju dizajn i pripravu novih cikličkih gvanidinskih sustava koji bi se mogli primijeniti u različitim istraživačkim područjima, uključujući anionsko prepoznavanje i homogenu katalizu, sintezu prirodnih produkata i bioaktivnih molekula.]]></summary_hr><summary_en><![CDATA[The scientific approach of the project is based on a combination of experimental and theoretical investigations. Project encompasses organic chemical synthesis, physico-chemical characterization of novel organic molecules, as well as quantum-chemical calculations and molecular modelling.The goal of the project is to investigate inherent physico-chemical properties of (poly)cyclic guanidines in which at least one nitrogen atom is embedded in heterocycle or attached to polycyclic structures. The objectives are: a) Synthesis of (poly)cyclic molecular systems possessing guanidine functionalities by employment of environmentally friendly synthetic methods (with the emphasize on cycloaddition reactions) and their spectroscopic and structural characterization; b) Mechanistic studies of reactions employed; c) Detailed insight into the fundamental molecular mechanisms how incorporation of guanidine moiety in cyclic structures mediates superbasicity properties; d) Development of model cyclic guanidine systems for anion sensing; e) Utilization of cyclic guanidine systems in development of base catalysis.The results of fundamental studies carried out within this project will enhance the understanding of physico-chemical factors governing superbasicity in cyclic systems and advance their design. Expected results will enable design and preparation of novel cyclic guanidine systems which could be applied in different research areas including anion sensing and homogeneous catalysis, synthesis of natural products and bioactive molecules.]]></summary_en></project><project>
<id>8022</id><title_hr><![CDATA[Od terena do nasada: karakteristike i prilagodljivost na stres prirodnih populacija pitomoga kestena i maruna]]></title_hr><title_en><![CDATA[]]></title_en><user_id>12402</user_id><user_firstLast_name>Vibor Roje</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-4332</code><acronim><![CDATA[CHESTNUT AND MARRON]]></acronim><duration>01.03.2019 - 31.08.2023</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet šumarstva i drvne tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Forestry and Wood Technology]]></institution_en><team_members_id>28741</team_members_id><team_members_names><![CDATA[ Doktorand: Katarina Tumpa ]]></team_members_names><keywords_hr><![CDATA[pitomi kesten, Castanea sativa, marun, raznolikost, adaptabilnost, epigenetika, rak kestenove kore, Cryphonectria parasitica, otpornost, sjemenske zon]]></keywords_hr><keywords_en><![CDATA[sweet chestnut, Castanea sativa, marron, variability, adaptability, epigenetics, chestnut blight, Cryphonectria parasitica, resistance, seed zones, Cr]]></keywords_en><summary_hr><![CDATA[Pitomi kesten (Castanea sativa Mill.) važana je, široko rasprostranjena, višestruko korisna vrsta drveća u mediteranskom području, od koje se koriste drvo, plodovi, med i tanin. Rak kestenove kore, uzrokovan introducirnom gljivom Cryphonectria parasitica, ugrožava opstanak sastojina pitomog kestena. Glavni cilj ovoga projekta je utvrditi: (1) neutralnu i adaptivnu raznolikost u prirodnim populacijama pitomog kestena u Hrvatskoj iz okolišno različitih staništa; (2) povezanost genetičke strukture, morfološke raznolikosti, kemijske raznolikosti i okolišnih razlika (klimatskih i pedoloških) u prirodnim populacijama i kultivarima pitomog kestena; (3) kvalitetu sjemena i zahtjeve za klijanje sjemena pitomog kestena; (4) genetičku osnovu raznolikosti za adaptivna svojstva na sadnicama uzgojenima u stakleniku i u recipročno-transpantacijskim pokusima; (5) epigenetičke odgovore na sušni stres; (6) tolerantnost selekcioniranih genotipova na patogene; (7) otpornost na patogene sadnica uzgojenih u rasadniku; (8) povezanost između populacijsko-genetičkog pristupa i pokusa u stakleniku kao i recipročno-transplantacijskih pokusa; (9) nastavak dugoročnog praćenja populacija C. parasitica; (10) neutralnu i adaptivnu raznolikost hrvatskih kultivara pitomog kestena; (11) razlike između hrvatskih kultivara pitomog kestena u morfologiji listova i plodova te kemijskom sastavu plodova; (12) razgraničenje sjemenskih zona i izrada smjernica za prijenos sjemena za hrvatske populacije pitomog kestena. Osim doprinosa osnovnim znanstvenim spoznajama o biologiji i ekološkim odnosima pitomog kestena, rezultati ovoga projekta doprinijet će održivom gospodarenju sastojinama pitomog kestena u Hrvatskoj. Rezultati će direktno doprinijeti zaštiti geografskog porijekla maruna, autohtonih hrvatskih kultivara pitomog kestena. Također će biti selekcionirani genotipovi tolerantni na sušni stres kao i oni s većom tolerancijom na biotski stres, odnosno infekciju gljivom Cryphonectria parasitica.]]></summary_hr><summary_en><![CDATA[The sweet chestnut (Castanea sativa Mill.) is a widely spread and important multipurpose tree species in the Mediterranean area, used for its wood, fruit, honey, and tannin. The chestnut blight, caused by the introduced fungus Cryphonectria parasitica, endangers the survival of the sweet chestnut stands. The main goal of this research is to reveal: (1) neutral and adaptive variability in sweet chestnut natural populations from different environmental habitats in Croatia; (2) associations between genetic structure, morphological variation, chemical variation and environmental differences (climatic and soil) in natural populations and in cultivars; (3) sweet chestnut seed quality and germination requirements; (4) genetic basis of variation for adaptive traits on seedlings reared in greenhouse and in reciprocal transplant experiments; (5) epigenetic responses to drought stress; (6) tolerance of selected genotypes to pathogens; (7) resistance to pathogens on seedlings reared in nursery; (8) associations between population genetic approach and greenhouse and reciprocal transplant experiments; (9) continuation of long term monitoring of C. parasitica populations; (10) neutral and adaptive variability in Croatian sweet chestnut cultivars; (11) differences in fruit and leaf morphology and chemical composition of fruits between Croatian marron cultivars; (12) delineation of seed zones and definition of seed transfer guidelines for Croatian sweet chestnut populations. Aside from contribution to the basic scientific knowledge on biology and ecological demands of sweet chestnut, the results will contribute to the sustainable management of sweet chestnut stands in Croatia. Results will contribute directly to the protection of geographic origin of the autochthonous marron cultivars. Croatian sweet chestnut genotypes tolerant to water stress and those with higher tolerance to biotic stress i.e. infection with C. parasitica, will be selected.]]></summary_en></project><project>
<id>8023</id><title_hr><![CDATA[ET TIBI DABO: naručitelji i donatori umjetnina u Istri, Hrvatskom primorju i sjevernoj Dalmaciji od 1300. do 1800. godine]]></title_hr><title_en><![CDATA[]]></title_en><user_id>269</user_id><user_firstLast_name>Nina Kudiš</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-8018</code><acronim><![CDATA[donart]]></acronim><duration>03.04.2019 - 02.04.2023</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Povijest umjetnosti, </scie_field_hr><scie_field_en>Art history, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Filozofski fakultet u Rijeci]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>27385</team_members_id><team_members_names><![CDATA[ Doktorand: Marin Bolić ]]></team_members_names><keywords_hr><![CDATA[donatori, naručitelji, društv. elite, Istra, Hr. primorje, sjev. Dalmacija, arhitektura, skulptura, slikarstvo, primijenjena umjetnost, 1300. – 1800. ]]></keywords_hr><keywords_en><![CDATA[donors, commissions, social elites, Istria, Croatian Littoral, North Dalmatia, architecture, sculpture, painting, applied arts, 1300 - 1800]]></keywords_en><summary_hr><![CDATA[Cilj projekta je istražiti utjecaj društvenih elita i pojedinaca na širenje umjetničkih oblika, stilova i rješenja. Taj su proces na području Hrvatske što je u žarištu ovog istraživanja, dijelom kreirali i najvažniji predstavnici europskih dvorova, poput habsburških careva, bavarskih vojvoda, venecijanskih duždeva, apostolskih nuncija i kardinala. Uvid u razloge i odlike njihovih narudžbi omogućit će bolje razumijevanje položaja i htijenja lokalnih donatora u europskom kontekstu. Primjenom metode istraživanja pojedinačnih slučajeva, pokušat će se doći do zaključaka, primjenjivih ne samo na područje jadranske Hrvatske, već i na teritorij Mletačke republike, Apeninskog poluotoka i Srednje Europe. U radu na projektu će uz voditeljicu sudjelovati još 12 istraživača, od kojih je 6 iskusnih znanstvenika s brojnim radovima objavljenim u Hrvatskoj i inozemstvu, a čak 6 mlađih istraživača su studenti doktorskih studija. Glavnina rada na projektu sastojat će se od istraživanja na terenu te usavršavanja u hrvatskim i inozemnim bibliotekama i arhivima. Rezultati istraživanja na projektu, čiji se dodir s interdisciplinarnošću ogleda u povezivanju povijesno-umjetničkog i historiografskog istraživanja, kao i istraživanja socijalnih fenomena, bit će od koristi istraživanjima u heraldici, genealogiji, sfragistici, etnologiji, povijesti književnosti, glazbe i mode te povijesti društva i kulture. U okviru projekta organizirat će se dvije znanstvene radionice i dva međunarodna znan. skupa na kojima će uz istraživače na projektu sudjelovati i drugi znanstvenici iz Hrvatske i inozemstva. Sva četiri skupa rezultirat će zbornicima radova opremljenima znanstvenom aparaturom te objavljenima na internetskoj stranici projekta. Jedan od važnih ciljeva projekta je i diseminacija rezultata istraživanja koja će se provoditi kroz javna predavanja istraživača, prisustvo u medijima, ali naročito kroz kraće diseminacijske tekstove koje će istraživači sustavno objavljivati na blog stranici projekta. ]]></summary_hr><summary_en><![CDATA[The project intends to investigate the influence of the social elites and individuals on the propagation of artistic forms, styles and solutions. In the Croatian territory that will be in the focus of this project, such a process was significantly shaped by the most important representatives of the European courts, such as Habsburg emperors, Bavarian Dukes, Venetian doges, Apostolic Nuncios and Cardinals. A better insight into reasons and characteristics of their commissions will generate a better understanding of the situation and aspirations of the local donors in the European context. By applying the “case study” methodology, we will try to reach conclusions, valid not only for the complete Croatian littoral, but also for the territory of the Venetian Republic, the Apennine Peninsula and Central Europe. Apart from the principal investigator, 12 researchers will take part in the project, half of which are experienced scholars with numerous papers published in Croatia and abroad and half of them are concluding their PhD studies. The project will mainly consist in field research and training and research in the Croatian and international libraries and archives. The results of the research, that interconnects art history and historiography, as well as the research of social phenomena, should also prove valuable for the research in heraldry, genealogy, sphragistics, ethnology, history of literature, music, fashion, as well as the cultural history. The project will also comprise two workshops for the participants and two international conferences, all resulting in proceedings that will be published online. One of the most important goals of the project is the dissemination of the research results through its web page and blog (numerous shorter articles by all the researchers), public lectures and the media.]]></summary_en></project><project>
<id>8025</id><title_hr><![CDATA[Application of Nanobiotechnology for Nutritional Supplementation with Selenium]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1258</user_id><user_firstLast_name>Tomislav Vinković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-1298</code><acronim><![CDATA[NutriNTENSe]]></acronim><duration>01.04.2019 - 01.07.2023</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Fakultet agrobiotehničkih znanosti Osijek]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Agrobiotechnical Sciences in Osijek]]></institution_en><team_members_id>26256</team_members_id><team_members_names><![CDATA[ Doktorand: Emerik Galić ]]></team_members_names><keywords_hr><![CDATA[selen, biofortifikacija, nanobiotehnologija, povrće, suplementacija hrane, prehrambeni otpad]]></keywords_hr><keywords_en><![CDATA[selenium, biofortification, nanobiotechnology, vegetables, nutritional supplementation, food waste]]></keywords_en><summary_hr><![CDATA[Selen (Se) je bitan mikroelement koji igra važnu ulogu u metabolizmu i mnogim drugim vitalnim funkcijama. Zbog svoje zaštitne aktivnosti tijekom imunološkog odgovora te kod karcinoma, Se se koristi kao dodatak prehrani. Budući da su biljke glavni izvor Se za ljude i životinje, različite strategije poput biofortifikacije i korištenja biljnih ekstrakata se koriste za razvoj prehrambenih dodataka na bazi Se. Biološka raspoloživost selena varira ovisno o nekoliko čimbenika, uključujući kemijski oblik Se, druge hranjive komponente u hrani, fiziološki status i status Se u organizmu. Glavne zapreke u postizanju optimalnog unosa Se su visoko varijabilni sadržaj u različitim vrstama hrane i uska sigurnosna granica unosa različitih Se oblika. Nanotehnologija omogućuje primjenu selenovih nanočestica (SeNPs), koje posjeduju jaču antioksidativnu aktivnost i nižu toksičnost u odnosu na druge oblike Se. NutriNTENSe projekt ima za cilj istražiti djelotvornost i sigurnost inovativnih nutraceutika i funkcionalne hrane na bazi SeNPs primjenom nanobiotehnoloških metoda. To će se postići razvojem dviju inovativnih klasa Se-nutraceutika: funkcionalnog biofortificiranog povrća sa SeNPs (FBVegs) i Se-nanoceutika (SeNCes) korištenjem ekstrakata prehrambenog otpada za biogenu sintezu SeNPs. Oba tipa Se-nutraceutika bit će podvrgnuta in vitro i/ili in vivo ispitivanjima kako bi se istražila njihova biokompatibilnost, sigurnost, farmakokinetička svojstva i farmakološka aktivnost u usporedbi sa selenatom i/ili kemijski sintetiziranim SeNPs. Osim toga, procijeniti će se moguće sinergističko djelovanje biogenih SeNPs i specifičnih bioaktivnih spojeva iz NutriNTENSe biljaka ili ekstrakata. Rezultati dobiveni NutriNTENse projektom biti će od velike koristi za potrošače, poljoprivredne proizvođače i prehrambenu industriju kao krajnje korisnike ishoda projekta. Treba istaknuti da NutriNTENse ima zeleni karakter s ciljem povećanja primjene zdravih i ekološki prihvatljivih proizvoda.]]></summary_hr><summary_en><![CDATA[Selenium (Se) is an essential trace element playing important role in metabolism and many other vital functions. Due to its protective activity in immune response and cancer, it is widely used as a diet supplement. As plants are the main dietary source of Se for humans and animals, different strategies such as biofortification and plant-based extracts are used to develop Se dietary supplements. Selenium bioavailability varies depending on several factors including chemical form of Se, other dietary components, physiological status and selenium status of the organism. The major obstacles in achieving optimal Se intake are highly variable Se content in different food types and narrow safety margin of supplemental Se forms. Nanotechnology enables application of selenium nanoparticles (SeNPs), due to their enhanced antioxidant activities and lower toxicity as compared to other Se forms. NutriNTENSe project aims to investigate the efficacy and safety of innovative SeNPs-based nutraceuticals and functional food using nanobiotechnological tools. This will be achived by following development of two innovative classes of Se-nutraceuticals: functional SeNPs biofortified vegetables (FBVegs) and Se-nanoceuticals (SeNCes) using food waste extracts for biogenic synthesis of SeNPs. Both types of Se-nutraceuticals will be subjected to in vitro and/or in vivo testings to investigate their biocompatibility, safety, pharmacokinetic properties and pharmacological activity compared to selenite and chemically synthesized SeNPs. In addition, possible synergistic action of biogenic SeNPs and specific bioactive compounds found in NutriNTENSe plants and extracts will be evaluated. Results obtained within NutriNTENse will be of great interest for consumers, agricultural producers and food industry as final beneficiaries of project outcomes. It should be highlighted that NutriNTENse is green project aimed to increase implementation of healthy and environment friendly products.]]></summary_en></project><project>
<id>8026</id><title_hr><![CDATA[Nano-katalizatori aktivirani Sunčevim zračenjem u tehnologijama zaštite okoliša]]></title_hr><title_en><![CDATA[]]></title_en><user_id>984</user_id><user_firstLast_name>Hrvoje Kušić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-4193</code><acronim><![CDATA[NaSCEnT]]></acronim><duration>11.02.2019 - 10.08.2023</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Kemijsko inženjerstvo, </scie_field_hr><scie_field_en>Chemical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet kemijskog inženjerstva i tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Chemical Engineering and Technology]]></institution_en><team_members_id>25653</team_members_id><team_members_names><![CDATA[ Doktorand: Klara Perović ]]></team_members_names><keywords_hr><![CDATA[solarna fotokataliza, nanokompozitni katalizatori, prioritetna onečišćivala, pročišćavanje vode, proizvodnja vodika]]></keywords_hr><keywords_en><![CDATA[solar photocatalysis, nanocomposite catalysts, priority substances, water purification, hydrogen production]]></keywords_en><summary_hr><![CDATA[Pristup pitkoj vodi i izvorima čiste energije neophodni su za ekonomski razvitak i napredak društva. Međuzavisnost proizvodnje energije i čiste vode dobro je poznata, međutim tehnologije trenutno nisu adekvatno integrirane. Inovativna ideja na kojoj počiva NaSCEnT projekt je dobivanje energije tijekom pročišćavanja vode. Takva hipoteza je utemeljena na istovjetnosti mehanizama koji se odvijaju tijekom fotokatalitičkog pročišćavanja vode te fotoelektrokemijskog cijepanja vode u svrhu dobivanja energije, to jest proizvodnju vodika (H2). Naime, oba procesa se temelje na istom osnovnom mehanizmu koji uključuje generiranje parova elektron/šupljina (e-/h+) na površini poluvodiča uslijed ekscitacije svjetlom, odnosno fotonima odgovarajuće energije. Glavni cilj NaSCEnT projekta je razvoj novog katalitičkog materijala nano-dimenzija (NKM), specifično razvijenog za učinkovito iskorištavanje Sunčeve energije u svrhu pročišćavanja vode i proizvodnje vodika. Sukladno tome, NKM će se pripremiti povezivanjem nanokompozitnih materijala sa poluvodičkim svojstvima na bazi TiO2, uz uključivanje SnS2, BiVO4, i ?-Fe2O3, te grafen oksida različitog stupnja redukcije (GO/rGO). Ciljana onečišćivala na kojima će se primijeniti solar/NKM sustav su farmaceutici, čiji su nusprodukti fotokatalitičke razgradnje niskomolekulske organske tvari koje mogu zamijeniti niskomolekulske alkohole koji se trenutno koriste u procesima fotoelektrokemijskog cijepanja vode. Optimiranje i procjena učinkovitosti solar/NKM sustava, uključujući okolišne, energetske i ekonomske aspekte, biti će provedena integriranjem računalnog i eksperimentalnog pristupa. Učinkovitost NKM-a će biti specifično podešavana kroz planirani dizajn i procedure sinteza, dok će se ugađanje ciljanih svojstava provesti pomoću modeliranja na molekularnoj razini. Rezultati NaSCEnT projekta imat će utjecaj na područja obrade vode i proizvodnje energije, te će utrti put ka primjeni nove, čiste i održive tehnologije.]]></summary_hr><summary_en><![CDATA[Accessible energy resources and clean water are nowadays among the highest priorities sustaining economic growth and societal wellbeing. Although the interdependency of energy and water is well known, the related technologies are still not sufficiently integrated. The groundbreaking idea of NaSCEnT project is to produce the clean energy while cleaning the water thus creating the shift of water-energy nexus paradigm. The underlying mechanism of photocatalytic processes for water purification and photoelectrochemical processes for energy conversion is basically the same. Both H2 production by water splitting and photocatalytic degradation of organic pollutants in water rely on the formation of electron/hole (e-/h+) pairs at a semiconducting material upon its excitation by the light with sufficient photon energy. The main goal of NaSCEnT is to develop novel nano-sized catalyst material (NCM) tailored to effectively harvest solar irradiation for simultaneous solar driven water purification and H2 production. Accordingly, NCM will be prepared by coupling semiconducting composites, made of TiO2 and semiconducting materials (SnS2, BiVO4, and ?-Fe2O3), and graphene oxide and its reduced form (GO/RGO). The NaSCEnT targets treatment of water polluted by pharmaceuticals. Their byproducts, low C-atom species, may mimic the role of lower C-atom alcohols, commonly used in H2 production in sole water splitting. The optimization and evaluation of solar/NCM system effectiveness, comprehending ecological, energetic and economic aspects will be performed integrating modeling and experimental approaches. The performance of NCM will be tailored through the planed design and development procedures. Fine tuning of the particular properties will be assisted by modeling at the molecular scale, thus minimizing the risk of the failure. The NaSCEnT results will address both water and energy fields and pave the way toward the application of innovative, clean and sustainable technologies.]]></summary_en></project><project>
<id>8027</id><title_hr><![CDATA[MATH-BTB proteini kao regulatori transkripcije i RNA posredovane metilacije DNA u biljnom razvitku]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4217</user_id><user_firstLast_name>Nataša Bauer</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-9542</code><acronim><![CDATA[PHYTOMETHDEV]]></acronim><duration>07.06.2019 - 01.01.2024</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>28653</team_members_id><team_members_names><![CDATA[ Doktorand: Mirta Tokić ]]></team_members_names><keywords_hr><![CDATA[metilacija DNA, RdDM, MATH-BTB, embriogeneza, stres, biljke]]></keywords_hr><keywords_en><![CDATA[DNA methylation, RdDM, MATH-BTB, embryogenesis, stress, plants]]></keywords_en><summary_hr><![CDATA[Metilacija DNA jedan je od nekoliko epigenetičkih mehanizama kontrole ekspresije gena. U biljaka raznolikost epigenetičkih mehanizama ima, osim u regulaciji razvojnih procesa, važnu ulogu u fenotipskoj i fiziološkoj prilagodljivosti, te sposobnosti biljaka da prežive i razmnožavaju se u promjenjivom okolišu. Metilacija biljne DNA odvija se na sljedovima CG, CHG i asimetričnom CHH (H simbol za A, C ili T), a svaki od njih ima različite &#39;&#39;genetičke zahtjeve&#39;&#39; za očuvanje. Nesimetrična metilacija CHH ne može se održati i zahtijeva de novo metilaciju u svakom staničnom ciklusu. Proces kojim se to ostvaruje je metilacija DNA usmjerena s RNA (RdDM). Dvije RNA polimeraze specifične za biljke, Pol IV i Pol V sintetiziraju male interferirajuće RNA, odnosno dugačke nekodirajuće molekule RNA, važne za RNA-DNA prepoznavanje. Kompleks DDR predstavlja proteinski kompleks za koji se smatra da je odgovoran za dovođenje enzima Pol V na mjesto regulacije gena, no mehanizam specifičnosti nije jasan. Naši preliminarni rezultati ukazuju da proteini MATH-BTB iz uročnjaka stupaju u interakciju s kompleksom DDR, te tako mogu posredovati u pozicioniranju sustava RdDM. Najnovija otkrića ukazuju da su supstrati proteina BPM transkripcijski faktori. Proteini s ovakvim interakcijskim mogućnostima imaju potencijal  održavanja ravnoteže između metilacije (posredovane Pol V) i transkripcije (posredovane Pol II). Glavni cilj projekta je rasvjetljavanje funkcionalne uloge proteina BPM u regulaciji transkripcije i RdDM-a kao i moguće uloge u biljnoj embriogenezi i prilagodbi na stresne uvjete. Posebna pozornost biti će dana identifikaciji gena čija je transkripcija ili RdDM metilacija uravnotežena proteinom BPM1 (kromatinska imunoprecipitacija-ChIP, ChIP-sekvenciranje). Nadalje, metilacijski uzorak (bisulfitno sekvenciranje) odabranih gena će biti povezan s njihovom ekspresijom (Q-PCR), te s embriogenezom i odgovorom biljaka na stres u linijama s promijenjenim sustavom RdDM ili ekspresijom gena BPM.]]></summary_hr><summary_en><![CDATA[DNA methylation is one of several epigenetic mechanisms used by cells to control gene expression. In plants epigenetic diversity, besides regulating development, presumably contributes in plant phenotypic and physiological plasticity and the ability to survive and reproduce in unpredictable environments. Plant DNA methylation occurs at CG, CHG and nonsymmetrical CHH (where H is A, C or T) sequences, each of which has different genetic requirements for its preservation. Nonsymmetrical CHH methylation cannot be sustained by the maintenance machinery and require de novo methylation in each cell cycle through a process called RNA-directed DNA methylation (RdDM). Two plant specific RNA polymerases, Pol IV and Pol V, produce small interfering RNAs and long non-coding RNAs respectively, which are important for RNA-DNA target sequence recognition. The DDR complex represents a major determinant that is proposed to be responsible for recruitment of the Pol V enzyme to the specific loci, but the mechanism is still not clear. Our preliminary results indicate that Arabidopsis MATH-BTB proteins recognize and interact with the DDR complex and thus might mediate the positioning of RdDM machinery. Recent findings indicate that substrates of BPM proteins are predominantly transcription factors. These two properties of a single BPM protein suggest its capacity to act as a control switch between methylation (mediated by Pol V) and transcription (mediated by Pol II). The main goal of this project is to elucidate the functional roles of BPMs in orchestrating transcription and RdDM, and its possible role in plant embryogenesis and stress adaptation. Particular focus will be placed to identification of genes whose transcription or RdDM methylation is affected by BPMs (by ChIP and ChIP seq). Further, methylation context (bisulfite sequencing) of selected genes will be correlated with their expression (Q-PCR) and with embryogeneis and stress responses in different RdDM and BPM mutant lines.]]></summary_en></project><project>
<id>8028</id><title_hr><![CDATA[Lobor - ranosrednjovjekovno središte moći]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6829</user_id><user_firstLast_name>Krešimir Filipec</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-5720</code><acronim><![CDATA[LearlyCoP]]></acronim><duration>08.03.2019 - 07.07.2023</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Arheologija, </scie_field_hr><scie_field_en>Archeology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>12780</team_members_id><team_members_names><![CDATA[ Doktorand: Petra Nikšić ]]></team_members_names><keywords_hr><![CDATA[Lobor, rani srednji vijek, središte moći, grobne cjeline, arheologija]]></keywords_hr><keywords_en><![CDATA[Lobor, early middle ages, center of power, grave units, archaeology]]></keywords_en><summary_hr><![CDATA[Vidljiva arheološka kultura, ali i bogatstvo u specifičnom središtu moći, kao što je Lobor u Panoniji, korespondira s onim što donose istraživanja te analiza pripadajućih grobnih cijelina. Interdisciplinarnim istraživačkim metodama na odabranom manjem broju grobnih cjelina (80 do 100), raspoređenih od 500. do 1100. godine ispitat će se mogućnosti arheološke i povijesne interpretacije. Predviđenim istraživanjima na odabranom mikro-lokalitetu (Lobor), namjera je pridonijeti boljem razumijevanju ne samo načina pokopa u Karpatskoj kotlini, time i u srednjoj Europi, u vidu poboljšanja kronologije i metodologije istraživanja grobalja te njihova odnosa prema miljeu u kojem su nastala, već također ispitati krajnje mogućnosti arheoloških i povijesnih izvora za europsku povijest srednjeg vijeka. Istraživanje će doprinjeti rekonstrukciji svakodnevnih kulturnih navika i značajki srednjovjekovne populacije. Projekt je usmjeren na proučavanje povijesnog, kulturološkog i biološkog totaliteta ljudske populacije na određenom prostoru na određenom i jedinstvenom uzorku. Namjera je dobiti cjelovitu sliku svakodnevnih kulturnih navika i obilježja ljudi te odrediti njihove životne i radne uvjete. ]]></summary_hr><summary_en><![CDATA[A clearly discernible archaelogical culture, and the richness of one specific centre of power such as Lobor in Pannonia, corresponds with what the research and analysis of the associated grave ensembles. The possibilities of archaeological and historical interpretation will be examined, through interdisciplinary research methods, on a selected number of grave ensembles (approximately 80 to 100 grave ensembles), dating from 500 to 1000 AD. The planned researches at the selected microlocality (Lobor) are planned to contribute to a better understanding of the manner of burial in the Carpathian Basin, i.e. Central Europe in terms of improving the chronology and the methodology of the research of cemeteries and how they relate to the milieu in which they were created, and also to provide an opportunity to examine the highest possibilities for them to be used as archaeological and historical sources for the medieval history of Europe. The research will contribute to the reconstruction of everyday cultural habits and characteristics of a medieval population. The project aims to study the historical, cultural and biological totality of a human population in a particular area and on a particular and unique sample. The intention is to get a complete picture of everyday cultural habits and characteristics of the people, and to determine their living and working conditions.]]></summary_en></project><project>
<id>8029</id><title_hr><![CDATA[Međuusporedba metoda mjerenja denudacije krša]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6006</user_id><user_firstLast_name>Kristina Krklec</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-5748</code><acronim><![CDATA[KADEME]]></acronim><duration>17.02.2020 - 17.02.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Geologija, </scie_field_hr><scie_field_en>Geology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Agronomski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Agriculture]]></institution_en><team_members_id>855332</team_members_id><team_members_names><![CDATA[ Doktorand: Mirna Švob ]]></team_members_names><keywords_hr><![CDATA[denudacija, trošenje stijena, tlo, krš, špilja]]></keywords_hr><keywords_en><![CDATA[denudation, rock weathering, soil, karst, cave]]></keywords_en><summary_hr><![CDATA[Denudacija površine temeljni je proces razvoja reljefa i tla. Otapanjem karbonata ostaje netopivi ostatak iz kojeg se može razviti tlo. Stoga je poznavanje brzine trošenja stijena i denudacije važno za evaluaciju potrebnog vremena za razvoj tla. Postoji nekoliko različitih metodoloških pristupa za mjerenje stope denudacije. Najčešće se koriste: izlaganje stijenskih pločica uvjetima u okolišu; upotreba mikro-erozijskog metra; mjerenje koncentracije kozmogenih radionuklida na izloženim stijenama i mjerenje hidrokemijskih značajki vode u svrhu određivanja količine otopljenih karbonatnih stijena. Svaka metoda ima prednosti i nedostatke i ne postoji konsenzus o tome koja metoda pruža najpouzdanije vrijednosti stope denudacije, štoviše, zabilježene su značajne razlike u rezultatima među metodama. Stoga ovo istraživanje ima za cilj identificirati metode koje bi mogle pružiti pristrane rezultate i ukazati na prednosti i nedostatke svake metode, kako bi se istraživačima olakšao odabir bolje metode ovisno o ciljevima njihovih istraživanja.Metode će se primijeniti na dvije različite lokacije pod utjecajem mediteranske klime, ali s vrlo različitom debljinom tla. Ovaj pristup važan je za vrednovanje sprege stope denudacije i debljine tla, te za utvrđivanje jesu li rezultati usporedbe metoda sustavni na mjestima s promjenjivom značajkama. Dobivene stope denudacije koristiti će se za procjenu produkcije materijala na lokacijama istraživanja, odnosno za proučavanje potencijalne proizvodnje tla ovisno o denudaciji. Važnost ovoga ogleda se u činjenici da je u scenariju erozije tla u mediteranskoj regiji važno znati potencijal oporavka tih sustava.]]></summary_hr><summary_en><![CDATA[Denudation of earth surface is the fundamental process governing the landscape and soil development. The dissolution of carbonates results in insoluble material of these rocks being available for the development of soils. Therefore, knowing rock denudation-weathering rates is important to evaluate the time required for a certain soil to develop. There are several different methodological approaches to measure denudation rate. The must commonly used are: the exposure of rock tablets to the natural environment; the use of micro-erosion meters; measuring the concentration of cosmogenic radionuclides on exposed rocks and measuring water hydrochemistry to infer amount of carbonates being dissolved. Every method has pros and cons and there is no consensus on which method provides the more reliable denudation rates, furthermore, significant differences among methods have been reported. Therefore, this investigation aims to identify methods that could provide biased results and as well to report the strengths and flaws of every method, to help researchers to select the better methods depending on the goals of their particular studies.The methods will be applied at two different locations affected by Mediterranean climate, but with very different soil thickness. This approach is important to evaluate the feedback of soil thickness on denudation rates, and confirm if the conclusions from the method comparison are systematic on sites with variable characteristics. The denudation rates obtained will be used to evaluate the production of material at the studied sites to study the potential production of soil depending on denudation. This is important, since in a scenario of soil erosion in the Mediterranean region, it is important to know the potential recovery of these systems. ]]></summary_en></project><project>
<id>8030</id><title_hr><![CDATA[Erozija i degradacija tala Hrvatske]]></title_hr><title_en><![CDATA[]]></title_en><user_id>20377</user_id><user_firstLast_name>Ivana Šestak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-6092</code><acronim><![CDATA[SEDCRO]]></acronim><duration>25.02.2019 - 24.02.2023</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Agronomski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Agriculture]]></institution_en><team_members_id>25711</team_members_id><team_members_names><![CDATA[ Doktorand: Iva  Hrelja ]]></team_members_names><keywords_hr><![CDATA[erozija tla vodom, degradacija tala, vinogradi, klimatske promjene, voćnjaci]]></keywords_hr><keywords_en><![CDATA[soil water erosion, soil degradation, vineyards, climate changes, orchards]]></keywords_en><summary_hr><![CDATA[Degradacija tla je glavni okolišni problem u svijetu i ključno je da takvi procesi budu ublaženi. Potreba da se smanji utjecaj poljoprivrednih aktivnosti na okoliš i kontrolira degradacija strukture tala je jedan od glavnih ciljeva gospodarenja tlima. Različite strategije su razvijene radi smanjenja najvažnijeg degradacijskog problema – erozije tla. Međutim, poljoprivreda je još uvijek izvor najviše sedimenata u površinskim otjecajnim vodama. Danas, mnoštvo razloga pokreće neprihvatljivo gospodarenje tlima na poljoprivrednim tlima RH. Usprkos važnosti teme istraživanja o degradaciji tala na poljoprivrednim tlima u RH nedostaju. Mehanizmi, procesi, proporcije i kontrola erozije tla bili su istraživani u „Zapadnim“ državama više od stoljeća, ali je nadopuna potrebna radi prenošenja novih saznanja i rasprave o novim izazovima. U RH takva istraživanja nedostaju što otvara mnoga pitanja tijekom svakodnevnih klimatskih ekstrema. Klimatske promjene povećavaju broj olujnih kiša. Takve oluje su uzrok netolerantnih erozijskih nanosa s razarajućim posljedicama po okoliš. Istraživanje erozije i degradacije tla na tlima u RH mogu pružiti detaljan uvid za razumijevanje procesa degradacije tala. Trenutna tema istraživanja može otkriti najugroženija tla i najlošije načine korištenja istih. Glavni faktori koji određuju gubitak tla erozijom i površinskim otjecanjem biti će ocjenjeni.Ovaj projekt predlaže kompletni pregled tla, korištenja zemljišta u drugačijim klimatskim uvjetima u Hrvatskoj koji se bave problemom erozije tla vodom. Baza podataka iz 5-godišnjeg istraživanja (s više od 40 lokacija) biti će jedan od najkompletnijih aktualnih baza za proučavanje utjecaja uzročnih čimbenika na eroziju tla vodom. ]]></summary_hr><summary_en><![CDATA[Soil degradation is a major environmental problem worldwide and is crucial that such processes must be mitigated. The need to reduce the environmental impact of agricultural activities and to control soil structure degradation is one of the main aims of land management. Strategies have been developed to reduce the most important degradation problem- soil erosion. However, agriculture is still the source of most sediments in surface runoff waters. Nowadays, complex of reasons are driving forces for unsustainable soil management practices in Croatian agricultural land. Despite the relevance of the topic there is lack of research on soil degradation on Croatian agricultural soils. The mechanisms, processes, rates and control of soil erosion have been scientifically studied in Western countries, but an update was needed to convey new findings and discuss new challenges. In Croatia, such research is missing which especially open the new dilemma during every-day climatic extremes. Climate changes increase a numbers of high rainfall intensity events. Such events triggered intolerant soil erosion rates with devastating consequences to environment.Research of soil erosion and degradation on Croatian soils can provide deep insight for understanding the processes of soil degradation. Present subject can help to discover most endanger soils and unsustainable land use practices. This project will quantify water and soil losses in Croatian agricultural soils under high intensity rainfall simulation on the soils under several land use and management strategies. The main factors that determine soil losses and runoff will be assessed.This project proposed an overview of soils, land use, and climatic conditions in Croatia that deal with the problem of soil water erosion. Dataset derived from 5 years research (from more than 40 locations) will be one of the most complete and up to-date databases for studying the effect of triggering factors on soil water erosion. ]]></summary_en></project><project>
<id>8031</id><title_hr><![CDATA[Razvoj integriranog mikrosustava za biokatalitičku proizvodnju biodizela]]></title_hr><title_en><![CDATA[]]></title_en><user_id>309</user_id><user_firstLast_name>Marina Tišma</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-5677</code><acronim><![CDATA[DeMSy(BioPro)2]]></acronim><duration>20.02.2019 - 19.02.2023</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Biotehnologija, </scie_field_hr><scie_field_en>Biotechnology, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Prehrambeno-tehnološki fakultet]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Food Technology]]></institution_en><team_members_id>25659</team_members_id><team_members_names><![CDATA[ Doktorand: Darijo Šibalić ]]></team_members_names><keywords_hr><![CDATA[biodizel, enzim lipaza, pročišćavanje, mikroreaktor, integrirani proces]]></keywords_hr><keywords_en><![CDATA[biodiesel, lipase, purification, microreactor, integrated process]]></keywords_en><summary_hr><![CDATA[U današnje vrijeme kada se raspoloživost i dostupnost fosilnih goriva značajno smanjuje, potreba za proizvodnjom biogoriva iz različitih obnovljivih izvora je sve izraženija. Biorazgradivost, netoksičnost i mala emisija štetnih tvari samo su neka od svojstava koja čine biodizel ekološki prihvatljivijim gorivom. Cilj ovog projekta je razviti integrirani mikrosustav za biokatalitičku proizvodnju biodizela. U tu svrhu će se proizvesti biokatalizator, enzim lipaza podrijetlom iz gljive Thermomyces lanuginosus fermentacijom na čvrstom otpadu prehrambene industrije kao supstrat, sintetizirati biodizel transesterifikacijom u kotlastom bioreaktoru i različitim mikroreaktoriskim sustavima korištenjem komercijalno dostupne i lipaze proizvedene fermentacijom na čvrstim nosačima pomoću gljive T. lanuginosus, provesti separaciju glicerola u prvoj fazi i pročišćavanje dobivenog biodizela u drugoj fazi primjenom membranske ultrafiltracije na modulima sa šupljim vlaknima kako bi proizvedeni biodizel kvantitativno i kvalitativno zadovoljio propisane norme. Kao supstrat u procesu transeterifikacije koristit će se svježe i otpadno jestivo ulje, a rezultati pokusa provedenih u različitim reaktorskim konfiguracijama će se usporediti kako bi se izabrao najpogodniji reakcijski sustav. Po prvi puta razvit će se integrirani mikroreaktorski sustav koji će na jednom čipu omogućiti kontinuiranu proizvodnju biodizela dok će se na drugom čipu odvijati kontinuirana separacija i pročišćavanje biodizela korištenjem filtera integriranih u sustav. Osim provedbe pokusa posebna pozornost će se posvetiti i razvoju matematičkog modela procesa proizvodnje biodizela u mikroreaktoru. Razvit će se 2D i 3D matematički model procesa, a rezultati simulacije matematičkog modela procesa koristit će se u svrhu boljeg razumijevanja strujanja reakcijske smjese u mikrokanalu, optimizacije procesa i uvećanja procesa.]]></summary_hr><summary_en><![CDATA[Nowadays as the availability and accessibility of fossil fuels is significantly declining, the need for the production of biofuels from various renewable sources is becoming increasingly interesting. Biodegradability, non-toxicity and low pollution emissions are merely some properties making biodiesel a more environmentally friendly fuel. The aim of this project is to develop an integrated microsystem for the biocatalytic production of biodiesel. For this purpose: (i) an enzyme lipase from the fungus Thermomyces lanuginosus will be produced on solid waste from food industry, (ii) biodiesel will be produced using transesterification reaction in a stirred-tank bioreactor and different microrector systems utilising a commercially available lipase and a lipase produced by solid-state fermentation using the fungus T. lanuginosus, (iii) separation of glycerol will be carried out in the first phase and purification of the obtained biodiesel in the second phase applying  the membrane ultrafiltration modules with hollow fibres to produce biodiesel that quantitatively and qualitatively fulfils the prescribed standards. Fresh and waste cooking oil will be used as a substrate in the transesterification process. The results of the experiments conducted in different reactor configurations will be compared in order to select the most appropriate reaction system. For the first time, an integrated microreactor system will be developed. The continuous production of biodiesel will take place in a single chip, while another chip will be used for continuous separation and purification of biodiesel using a filter integrated into the system. Special attention will be paid to the development of mathematical models for biodiesel production in a microreactor. 2D and 3D mathematical models will be developed for the processes and the results of mathematical model simulations will be used to better understand the flow of the reaction mixture, process optimization and process scale up.]]></summary_en></project><project>
<id>8032</id><title_hr><![CDATA[Timska adaptabilnost u razvoju inovativnih proizvoda]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4471</user_id><user_firstLast_name>Mario Štorga</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-5773</code><acronim><![CDATA[TAIDE]]></acronim><duration>15.03.2019 - 14.06.2023</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, </scie_field_hr><scie_field_en>Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>27167</team_members_id><team_members_names><![CDATA[ Doktorand: Ivan Čeh ]]></team_members_names><keywords_hr><![CDATA[timski rad, inovativni razvoj proizvoda, adaptabilnost, simulacije, eksprimentalno istraživanje u konstruiranju]]></keywords_hr><keywords_en><![CDATA[teamwork, innovative product development, adaptability, simulation, experimental design research]]></keywords_en><summary_hr><![CDATA[Inženjerski timovi se često koriste u dinamičnom okruženju koje zahtijevaa adaptaciju I promjenu zbog različitih utjecajnih faktora; timovi se moraju prilagoditi promjenama tržišnih trendova, tehnologije ili ograničenjima resursa. Kako se istraživačko područje koje se bavi inženjerskim timovima razvija, istraživanje u ovom području sve više zahtjeva interdisciplinarne pristupe za razumijevanje, modeliranje i unapređenje uloge koje timovi imaju u razvoju proizvoda. S obzirom na to da brojni faktori koji utječu na timski rad ovise o raspoloživom kontekstu aktivnosti, predviđanje performansi timova koji rade licem-u-lice ili u virtualnoj okolini je iznimno zahtjevno, te je očiti nedostatak istraživačkih studija u tom području.Cilj predloženog istraživanja je razvoj istraživačkog i konceptualnog okvira za eksperimentalno istraživanje inženjerskih timova (licem-u-lice kao i u virtualnoj okolini) koji rade na razvoju inovativnih proizvoda. Predloženi projekt će doprinijeti teoriji i praksi kroz interdisciplinarno istraživanje te će se nadograditi na rezultate trenutno aktivnog HRZZ projekta MINMED. Tijekom projekta kao istraživačka metodologija će se koristiti metodologija istraživanja u znanosti o konstruiranju, dok će metode eksperimentalnog istraživanje u konstruiranju biti glavna istraživačka paradigm.Od rezultata projekta se očekuje da ocrtaju kako empirijsko istraživanje i računalne simulacije timskog rada mogu dovesti do boljeg razumijevanja, modeliranja, I unapređenja timska adaptabilnosti kao jednog od glavnih svojstava timskog rada koje je važno za inovativnost. Računalni alati koji će nastati kao rezultat istraživanja trebali bi omogućiti istraživačima te ljudima iz industrije korištenje računalnih simulacija za razumijevanje uloge koju različiti uzroci poremećaja u radu imaju na timsku adaptabilnost.Istraživanje će se izvoditi u multidisciplinarnom okruženju koje uključuje istraživače, ali i istraživačku infrastrukturu u Hrvatskoj, Danskoj, Švedskoj i SAD.]]></summary_hr><summary_en><![CDATA[Engineering teams are often used in dynamic environments that require adaptation and constant change due to external and internal circumstances; they have to adjust to changes in market trends, and adapt to changing technologies or resources constraints. As the research field concerning engineering teams develops, it continues to require interdisciplinary approaches to understand, model and improve the role of the teamwork in product development. However, since there are numerous factors influencing teamwork depend on time and context, understanding and predicting face-to-face and virtual team performance is exceptionally challenging, and there are insufficient research studies.The goal of the proposed research project is the development of the research and conceptualisation framework for experimental studies of engineering teams (both face-to-face and virtual) within innovation-oriented product development projects. The proposed project will contribute to both the theory and practice by bringing together interdisciplinary research and it will build on the results of the ongoing CSF project MINMED. During the project, the Design Science Research framework will be applied as the research methodology, while experimental design research will be the primary research paradigm. The results are expected to delineate how empirical research and computational simulations can lead to better understanding, modelling, reflection on and improvement of team adaptability as one of the most important emergent properties of the engineering teams in relation to innovation. The resulting computational tools should enable researchers and practitioners from the industry to utilise simulations to understand the role that the different types of disruption triggers have on the resulting team adaptation.The research will be conducted by a multidisciplinary research group including the researchers and research infrastructure for experimentation from Croatia, USA, Denmark and Sweden.]]></summary_en></project><project>
<id>8033</id><title_hr><![CDATA[Ekstrakcija bioaktivnih biljnih sastavnica pomoću zelenih otapala – korak prema zelenim kozmeceuticima]]></title_hr><title_en><![CDATA[]]></title_en><user_id>21380</user_id><user_firstLast_name>Kristina Radić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-3795</code><acronim><![CDATA[CosmoGreen]]></acronim><duration>15.04.2019 - 11.04.2026</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Farmacija, </scie_field_hr><scie_field_en>Pharmaceutical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Farmaceutsko-biokemijski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Pharmacy and Biochemistry]]></institution_en><team_members_id>26076</team_members_id><team_members_names><![CDATA[ Doktorand: Marina Jurić ]]></team_members_names><keywords_hr><![CDATA[Anti-aging, fibroblasti, izolacija vođena bioaktivnošću, kozmeceutici, optimizacija ekstrakcije, zelena otapala]]></keywords_hr><keywords_en><![CDATA[Anti-aging, bioactivity guided isolation, cosmeceuticals, extraction optimization, fibroblasts, green solvents]]></keywords_en><summary_hr><![CDATA[Mnogobrojne biljne sastavnice mogu utjecati na različite mete u ljudskom organizmu, uključujući stanice kože i ekstracelularni matriks. Na taj način one mogu djelovati ne samo na izgled nego i na zdravlje ovog važnog organa. Zbog toga se biljni ekstrakti često koriste u izradi takozvanih &#39;&#39;kozmeceutika&#39;&#39;, proizvoda za koje se smatra da imaju značajke kozmetike i lijekova. Prirodno porijeklo sastavnica takvih proizvoda, što uključuje i aktivne i pomoćne tvari, vrlo je poželjno. Stoga bi otapala koja se koriste za ekstrakciju biljnog materijala trebala biti prirodnog porijekla, biorazgradiva i netoksična. Nadalje, postupak ekstrakcije trebao bi biti usmjeren k povećanju sadržaja aktivne tvari u ekstraktima. Također je poželjno da otapalo ne bude samo pasivni nosač aktivne tvari nego i da učinkovito povećava njezinu djelotvornost. U sklopu projekta biti će priređena serija ekstrakata kopnenih i morskih organizama. Izolirat će se njihove aktivne sastavnice te odrediti njihova struktura. Biološka aktivnost ekstrakata bit će detaljno ispitana korištenjem više enzimskih testova te ispitivanja na stanicama. Odredit će se optimalni uvjeti ekstrakcije aktivnih tvari. Rezultati projekta bit će primjenjivi u razvoju kozmetičkih i dermatoloških proizvoda. Imajući na umu da će dio biljnog materijala koji će se koristiti u istraživanju biti dobiven iz otpadne biomase, rezultati će imati značajan ekonomski i ekološki potencijal  za proizvodnju kozmetike iz obnovljivih izvora. ]]></summary_hr><summary_en><![CDATA[Numerous plant secondary metabolites can affect multiple targets in human body, including skin cells and extracellular matrix. In this way, they can influence not only look, but also overall health of this important organ. For this reason plant extracts are often part of so-called “cosmeceuticals”, products combining the principles of cosmetics and drugs. Natural origin of such products&#39; ingredients, including both the active principles and the excipients, is highly valued. Therefore, the solvent used for the extraction of plant material should be of natural origin, biodegradable and non-toxic. Furthermore, the extraction process should be aimed at increasing the content of the active ingredient in the extract. Finally, it is desirable that the solvent is not only a passive carrier of the bioactive molecule but that it effectively enhances its desired activity. In the course of the project, a series of extracts from both terrestrial and marine organisms using non-toxic solvents of natural origin will be prepared. Their active constituents will be isolated, their structure determined and the biological activity thoroughly tested using several enzyme and cellular assays. Optimal conditions for the &#39;&#39;green&#39;&#39; extraction of active principles will be determined. The findings of this project will be applicable in development of cosmetic and dermatological products. Having in mind that the part of plant material used for the extraction will be obtained from waste biomass, the results will have a significant economical and ecological potential for production of cosmetics from renewable sources.]]></summary_en></project><project>
<id>8034</id><title_hr><![CDATA[Unapređenje usluga šumskih ekosustava Hrvatske kroz vrednovanje bioraznolikosti gljiva temeljenoj na DNA barkodiranju]]></title_hr><title_en><![CDATA[]]></title_en><user_id>19224</user_id><user_firstLast_name>Armin Mešić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-7081</code><acronim><![CDATA[ForFungiDNA]]></acronim><duration>06.05.2019 - 05.02.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>26553</team_members_id><team_members_names><![CDATA[ Doktorand: Ana Pošta ]]></team_members_names><keywords_hr><![CDATA[šumarstvo, usluge šumskih ekosustava, gljive, bioraznolikost, DNA barkodiranje, integrativna taksonomija, biogeografija, fitopatologija]]></keywords_hr><keywords_en><![CDATA[forestry, forest ecosystem services, fungi, biodiversity, DNA barcoding, integrative taxonomy, biogeography, phytopathology]]></keywords_en><summary_hr><![CDATA[Usluge ekosustava su ekološke značajke, funkcije ili procesi ekosustava koji imaju utjecaj na ljudsko blagostanje. Očuvanje cjelokupne biološke raznolikosti u šumama ima izrazito pozitivan utjecaj na unapređivanje usluga šumskih ekosustava. U ukupnoj kopnenoj površini Republike Hrvatske šume zauzimaju oko 37%. Zbog položaja na razmeđi kontinentalne, sredozemne, panonske i alpske biogeografske regije, Hrvatska se u europskim okvirima ističe vrlo velikom bioraznolikošću. Šume su najsloženiji kopneni ekosustavi i najznačajniji tip staništa za gljive u kojem živi najveći broj gljivljih vrsta. Gljive u šumskim staništima imaju ključne ekološke uloge i nužne su za zdravlje i opstanak šuma. Ljudski utjecaj koji se ogleda u često prekomjernom iskorištavanju prirodnih resursa i položaj u jednom od svjetskih žarišta klimatskih promjena čine biološku raznolikost u hrvatskim šumama vrlo ugroženom. Gljive su u Hrvatskoj daleko najslabije istražena skupina organizama, pri čemu je do danas poznato tek oko 23% od ukupno procijenjenog broja vrsta. Glavni cilj projekta je istražiti bioraznolikost gljiva u šumama Hrvatske uz pomoć metoda DNA barkodiranja, te analizirati njen utjecaj na usluge šumskih ekosustava. Važan rezultat projekta biti će nadopunjavanje bioinformatičkih međunarodnih baza podataka DNA sekvencama gljivljih vrsta koje do danas u tim bazama nisu zastupljene. Sve vrste za koje su u ovom projektu dobiveni DNA barkodovi kategorizirat će se u trofičke skupine (patogene, mikorizne i saprotrofne vrste) i procijenit će se status ugroženosti tih vrsta u Hrvatskoj. Rezultati projekta imat će veliki potencijal primjene u šumarstvu, prehrambenoj industriji, farmaciji te zaštiti prirode. Podaci o DNA barkodovima vrsta gljiva posebno će biti značajni u šumarstvu za relativno brzu i preciznu identifikaciju, kontrolu i suzbijanje patogena drveća, ali i za identifikaciju mikoriznih i saprotrofnih vrsta.]]></summary_hr><summary_en><![CDATA[Ecosystem services are the ecological characteristics, functions, or ecosystem processes that contribute to human wellbeing. Conservation of the overall biodiversity in the forests has strong positive effect on the enhancement of forest ecosystem services. About 37% of the total land area of the Republic of Croatia is covered by forests. Croatia is distinguished by the great biodiversity due to its position on the dividing line between Continental, Mediterranean, Pannonian and Alpine biogeographical regions. Forests are the most complex terrestrial ecosystems and the most important habitat for fungi. Fungi play key ecological roles in the forests and are necessary for the forest health and existence. Human over-exploitation of natural resources and the geographical position of Croatia in the climate change hot-spot area, make biodiversity of its forests highly endangered. Fungi are the far least studied group of organisms in Croatia with only 23% of species recorded so far out of the total estimated number. The main project aim is to study fungal biodiversity of Croatian forests through the DNA barcoding methods and to analyze its impact on forest ecosystem services. The project will result in the addition of fungal DNA sequences to international bioinformatic databases for a number of species that are not represented in these bases to date. All DNA barcoded species in this project will be categorised in trophic groups (pathogens, saprotrophs, and mycorrhizal species) and the intensity of their impact on the forest ecosystem services will be assessed. The project results will have great potential for different applications in forestry, food industry, pharmacy and nature conservation. Application of DNA fungal barcodes will be especially important in forestry for relatively fast and accurate identification, control, and suppression of plant pathogens, as well as for identification of mycorrhizal and saprotrophic species.]]></summary_en></project><project>
<id>8035</id><title_hr><![CDATA[Istraživanje antioksidativnog djelovanja benzazolskog skeleta u dizajnu novih antitumorskih agensa]]></title_hr><title_en><![CDATA[]]></title_en><user_id>2914</user_id><user_firstLast_name>Marijana Hranjec</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-7463</code><acronim><![CDATA[AntioxPot]]></acronim><duration>18.02.2019 - 17.06.2023</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet kemijskog inženjerstva i tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Chemical Engineering and Technology]]></institution_en><team_members_id>26992</team_members_id><team_members_names><![CDATA[ Doktorand: Anja Beč ]]></team_members_names><keywords_hr><![CDATA[sinteza, benzazoli, računalna kemija, antioksidativna aktivnost, antitumorska aktivnost]]></keywords_hr><keywords_en><![CDATA[synthesis, benzazoles, computational chemistry, antioxidative activity, antitumor activity]]></keywords_en><summary_hr><![CDATA[Predloženi znanstveni projekt usmjeren je na dizajn i razvoj novih i učinkovitih derivata benzazola kao antioksidansa s antitumorskom aktivnošću koji će biti dio antitumorske terapeutske strategije temeljene na inhibiciji ROS-a. Projekt je multidisciplinaran i okuplja interdisciplinarnu skupinu istraživača čija zajednička sinergija treba voditi do ostvarenja glavnih ciljeva projekta. Projekt će se sastojati od tri glavna cilja, uključujući sintezu i strukturnu karakterizaciju derivata benzazola, računalna istraživanja i određivanje biološke aktivnosti. Tijekom projekta sintetizirat će se mala biblioteka derivata benzazola, a dodatno će ovo zajedničko istraživanje rezultirati optimizacijom benzazolskog skeleta što bi trebalo osigurati bolju aktivnost i optimirana svojstva odabranih vodećih spojeva kao antioksidativnih i antitumorskih agensa. Računalna kemija i QSAR modeliranje omogućit će strukturnu optimizaciju odabranih vodećih spojeva. Biološka ispitivanja uključivat će in vitro metode za određivanje antioksidativne aktivnosti. Dodatno, odabranim spojevima odredit će se antiproliferativna aktivnost in vitro na humane stanice karcinoma. Da bi se dodatno objasnili mehanizmi biološkog djelovanja vodećih spojeva, provest će se procjena razine ROS-a u stanicama i mitohondrijima, analiza oksidativnih oštećenja DNK te procjena ekspresije proteina. Jedan od ciljeva projekta bit će i razvoj manje toksičnih derivata kao potencijalnih fluorescentnih proba za detekciju biomakromolekula. Zaključno, predstavljeno istraživanje temelji se na zajedničkim istraživanjima različitih institucija uključujući istraživače iz različitih znanstvenih područja. Predloženi projekt temelji se na istraživanju u području medicinske kemije, s naglaskom na moguća daljnja ciljana istraživanja kao i daljnji razvoj naše znanstvene skupine na međunarodnoj razini.]]></summary_hr><summary_en><![CDATA[The proposed scientific project is oriented towards the design and development of novel and efficient benzazole derivatives as antioxidants with antitumor activity as a part of antitumor therapeutic strategy based on inhibition of ROS. The project is highly multidisciplinary and brings together an interdisciplinary team of researchers whose common synergy will lead to the main goals of the project. The project will consist of three main objectives including synthesis and structural characterization of benzazole derivatives, computational research and biological evaluation. Within the project synthesis of small library of benzazole derivatives will be performed while additionally this collaborative research should result in the optimization of the benzazole scaffold which will ensure more efficient activity and optimized properties of lead compounds as antioxidants and antitumor agents. Computational chemistry and QSAR modelling will allow a structural optimization of chosen lead compounds. Biological evaluation will include in vitro assays for evaluation of antioxidative activity. Additionally, the chosen compounds will be tested for antitproliferative activity in vitro on human cancer cells. To get more insight into the mechanisms of action of lead compounds the assessment of ROS levels in the cells as well in mitochondria, along with the oxidative DNA damage and analysis of expression of proteins will be performed. One of the objectives will be the development of less toxic derivatives as potential fluorescent probes for detection of biomacromolecules. Finally, the presented research is based on joint research of different institutions including researchers from different scientific fields. Proposed project is based on the research in the field of medicinal chemistry with focus on possible further target research as well as further development of our scientific group on the international level.]]></summary_en></project><project>
<id>8036</id><title_hr><![CDATA[Istraživanje granice između neurodegeneracije i neuroregeneracije: identifikacija ključnih molekula pomoću proteomike i funkcionalnih testova na leđnoj moždini sisavaca]]></title_hr><title_en><![CDATA[]]></title_en><user_id>19076</user_id><user_firstLast_name>Jelena Ban</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-1155</code><acronim><![CDATA[DefineREgenAgeMode]]></acronim><duration>04.03.2019 - 03.09.2023</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Interdisciplinarno područje znanosti</scie_area_hr><scie_area_en>Interdisciplinary scientific area</scie_area_en><scie_field_hr>Biotehnologija u biomedicini, </scie_field_hr><scie_field_en>Biotechnology in Biomedicine, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Fakultet biotehnologije i razvoja lijekova]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Biotechnology and Drug Development]]></institution_en><team_members_id>25289</team_members_id><team_members_names><![CDATA[ Doktorand: Zrinko Baričević ]]></team_members_names><keywords_hr><![CDATA[regeneracija sisavaca, Monodelphis domestica, oposum, embrionalni razvoj, središnji živčani sustav, leđna moždina, rast aksona, proteomika]]></keywords_hr><keywords_en><![CDATA[mammalian regeneration, Monodelphis domestica, opossum, embryonal development, central nervous system, spinal cord, axonal growth, proteomics]]></keywords_en><summary_hr><![CDATA[Jedan od glavnih izazova suvremene biologije je nemogućnost odraslog središnjeg živčanog sustava (SŽS) sisavaca da se regenerira i oporavi nakon ozljede. Za razliku od odraslih sisavaca, niži kralježnjaci, kao što su ribe i vodozemci, te viši kralježnjaci tijekom embrionalnog razvoja mogu obnoviti znatan dio svog SŽS. Vrlo je nejasno kako se i zašto regenerativni potencijal gubi tijekom evolucije i razvoja i zašto je vrlo ograničen u odraslih sisavaca. Povoljan model za istraživanje i otkrivanje osnove ovog gubitka je mladi oposum (Monodelphis domestica). Oposumi su tobolčari koji se rađaju vrlo nezreli i imaju jedinstvenu mogućnost uspješne regeneracije leđne moždine nakon ozljede u prva dva tjedna svog života, te stoga pružaju izuzetnu priliku za istraživanje neuronalne regeneracije. U svojim sam prethodnim istraživanima identificirala gene čiji se izražaj razlikuje u tkivu leđne moždine oposuma koji imaju ili nemaju sposobnost regeneracije. U ovom istraživanju želimo nadograditi prijašnji pristup analizom proteoma tkiva leđne moždine oposuma različite dobi, kako bi se otkrile molekule povezane s regenerativnim rastom aksona i proliferacijom matičnih stanica. Inhibicijom aktivnosti odabranih molekula ispitat će se njihova funkcionalna uloga u regeneraciji živčanog tkiva, koristeći in vitro preparate intaktne leđne moždine i napredno mikroskopiranje. Paralelno, pripremiti ćemo i analizirati primarne stanične kulture iz tkiva leđne moždine oposuma različite dobi, kako bi testirali odabrane molekule, s težištem na onima koje kontroliraju aktivnost matičnih stanica vezanu za regeneraciju. Ovo originalno interdisciplinarno temeljno istraživanje koristi jedinstveni životinjski model i ujedinjuje napredne tehnike biotehnologije te molekularne i stanične neurobiologije. Rezultati ovog projekta mogli bi dati značajan doprinos razumijevanju regeneracije živčanog tkiva sisavaca, ali i pružiti osnovu za buduće nove terapijske postupke vezane za neurodegenerativne poremećaje.]]></summary_hr><summary_en><![CDATA[One of the major challenges of modern biology concerns the inability of the adult mammalian central nervous system (CNS) to regenerate and repair itself after injury. Unlike the situation in adult mammals, lower vertebrates, such as fish and amphibians, and embryonal higher vertebrates can regenerate significant portions of their CNS. It is poorly understood why this potential is lost with evolution and development, and becomes very limited in adult mammals. An advantageous model to understand the basis of this loss is the neonatal opossum (Monodelphis domestica). Opossums are marsupials born immature, with the unique ability to successfully regenerate spinal cord after injury postnatally: this property, therefore, offers an exceptional tool to study neuro-regeneration. In my previous studies I have identified the genes differentially expressed in the regenerating and non-regenerating opossum spinal tissue. In the present application we wish to upgrade approach and to analyze the proteoms of the spinal tissue of the opossums at different ages, looking for molecules associated with regenerative axon growth and stem cell proliferation. The activity of candidate molecules will be inhibited to investigate their functional role in neuronal regeneration using the in vitro intact spinal cord preparation and advanced imaging. In parallel, we will prepare and analyze opossum primary spinal cell cultures made from the animals of different age, to test candidate proteins, with focus on those involved in stem/progenitor cell activity related to regeneration. This original interdisciplinary basic research project, unique in the choice of the animal model to be used, combines advanced techniques of biotechnology and molecular and cellular neurobiology. The results of the project would make substantial contribution to our understanding of neuronal regeneration in mammals, and also provide candidate targets for future novel therapeutic interventions for neurodegenerative disorders.]]></summary_en></project><project>
<id>8037</id><title_hr><![CDATA[Enzimska sinteza fluoriranih kiralnih građevnih blokova]]></title_hr><title_en><![CDATA[]]></title_en><user_id>352</user_id><user_firstLast_name>Zvjezdana Findrik Blažević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-6070</code><acronim><![CDATA[EnzyFluor]]></acronim><duration>01.04.2019 - 31.03.2023</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Kemijsko inženjerstvo, </scie_field_hr><scie_field_en>Chemical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet kemijskog inženjerstva i tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Chemical Engineering and Technology]]></institution_en><team_members_id>28627</team_members_id><team_members_names><![CDATA[ Doktorand: Nevena Milčić ]]></team_members_names><keywords_hr><![CDATA[biokataliza, halogenhidrin-dehalogenaze, fluorirani kiralni građevni blokovi, kinetički model, molekulsko modeliranje]]></keywords_hr><keywords_en><![CDATA[biocatalysis, halohydrin dehalogenases, fluorinated building blocks, kinetical model, in sillico]]></keywords_en><summary_hr><![CDATA[Predloženi projekt usmjeren je na dizajn enzimskih transformacija kojima se polazeći iz epoksida, mogu pripraviti sintetski korisni fluorirani građevni blokovi. Halogenhidrin-dehalogenaze (HHDH), relativno nova i još uvijek nedovoljno istražena grupa enzima, koristit će se kao biokatalizatori. Fokus istraživanja će biti na procjeni utjecaja organskih otapala kao medija za provođenje ovih biotransformacija. Upotreba organskih otapala može imati prednosti u slučaju HHDH-kataliziranih reakcija. Prvenstveno se to odnosi na povećanje topljivosti i stabilnosti supstrata, što rezultira većim prinosom produkata. Ciljane transformacije su reakcije otvaranja fluoriranih derivata aril epoksida u prisutnosti natrij azida i natrij cijanida kao nukleofila. U reakcijama će se ispitati niz divljih tipova te genetski optimiziranih enzima radi odabira biokatalizatora s najboljim katalitičkim svojstvima. Korištenjem molekulskog uklapanja i metoda QM/MM odredit će se važni sterički i elektronski faktori koji utječu na katalitičku aktivnost, enantio- i/ili regioselektivnost reakcija.  Metode molekulske dinamike koristit će se i za ispitivanje utjecaja organskog otapala na strukturu, dinamiku i katalitičku aktivnost enzima. Nadalje, ispitat će se različita organska otapala u smjesi s vodom (monofazni i dvofazni sustavi) ili čista kao medij za provođenje enzimskih reakcija. Na odabranim sustavima odredit će se kinetike enzimskih reakcija, te utvrditi operacijska stabilnost enzima. Razvijeni kinetički modeli procesa će se koristiti za njihovu optimizaciju, tj. pronalaženje optimalnih radnih uvjeta kako bi se postigla maksimalna konverzija supstrata, enantiomerna čistoća produkta i/ili volumna produktivnost procesa, kao i za odabir najpovoljnijeg tipa reaktora za provedbu procesa te za uvećanje procesa. ]]></summary_hr><summary_en><![CDATA[The proposed project aims at the design of enzymatic conversions for the production of synthetically useful fluorinated chiral building blocks from epoxides. Halohydrin dehalogenases (HHDH), relatively new and still not sufficiently explored group of enzymes, will be used as biocatalysts. The strong focus will be on the evaluation of aqueous-organic solvent mixtures and pure organic solvents as reaction media. The use of organic media can offer significant advantages in the case of HHDH-catalysed transformations. In particular, it could lead to higher productivity, due to better solubility and stability of substrates. The target conversions are incorporation of cyano and azido groups through the HHDH-catalysed ring-opening reaction of fluorine-substituted aryl epoxides. The approach will be to select enzymes by screening a number of known wild-type and mutant enzymes. After the appropriate enzyme(s) and substrate(s) are selected, different organic solvents will be tested as media for the reaction, either as water-organic solvent mixtures or pure organic solvents. The important steric and electronic factors governing the catalytic activity, enantio- and / or regio-selectivity will be determined by using the molecular docking and QM/MM calculations in combination with the in silico mutagenesis study. The MD simulation in non-aqueous medium will be used for investigating the solvent effects on the structural and dynamic properties of HHDHs as well as their catalytic activity.  Furthermore, enzyme(s) will be kinetically characterized in the selected reaction media and its operational stability will be evaluated. Kinetical model of the process will be developed in order to facilitate the reaction optimization. With the use of the kinetic model it is possible to determine the best reactor type for the investigated reaction, and to find initial conditions to achieve high productivity, substrate conversion and product yield without extensive experimental work.]]></summary_en></project><project>
<id>8038</id><title_hr><![CDATA[„Napredne metode i tehnologije u znanosti o podatcima i kooperativnim sustavima (DATACROSS)“ Znanstvenoga centra izvrsnosti za znanost o podacima i kooperativne sustave (ZCI)]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4132</user_id><user_firstLast_name>Ivan Marković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-9877</code><acronim><![CDATA[]]></acronim><duration>01.04.2019 - 01.11.2023</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>28661</team_members_id><team_members_names><![CDATA[ Doktorand: Antea Hadviger Hadviger ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>8039</id><title_hr><![CDATA[Centar izvrsnosti za znanost i tehnologiju – integracija Mediteranske regije ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>74</user_id><user_firstLast_name>Sandi  Orlić </user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-1550</code><acronim><![CDATA[]]></acronim><duration>01.04.2019 - 01.10.2023</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Interdisciplinarne prirodne znanosti, </scie_field_hr><scie_field_en>Interdisciplinary natural sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>25954</team_members_id><team_members_names><![CDATA[ Doktorand: Lorena Selak ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>8040</id><title_hr><![CDATA[Dinamika defekta u nanomaterijalima: istraživanje putem eksperimenata s ionskim tragovima]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3498</user_id><user_firstLast_name>Marko Karlušić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-5771</code><acronim><![CDATA[DyNaMITE++]]></acronim><duration>14.03.2019 - 14.09.2023</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>25833</team_members_id><team_members_names><![CDATA[ Doktorand: Juraj Hanžek ]]></team_members_names><keywords_hr><![CDATA[brzi teški ion, ionski trag, defekt, RBS/c, Ramanova spektroskopija, AFM, grafen]]></keywords_hr><keywords_en><![CDATA[swift heavy ion, ion track, defect, RBS/c, Raman spectroscopy, AFM, graphene]]></keywords_en><summary_hr><![CDATA[Napredni materijali i napredne tehnike procesiranja materijala osnova su suvremene tehnologije. Znanstveni napredak započet nedavnim otkrićem grafena koji u jednom materijalu sažima više izvanrednih svojstava, obećaje naslućene mogućnosti koje bi mogle uzrokovati velike promjene u sadašnjim industrijskim procesima i rezultirati radikalno novim proizvodima. Zato je kontrola svojstava ovih novih i uzbudljivih nanomaterijala od najveće važnosti za bilo koju industrijsku primjenu.Ionska implantacija je dobar primjer u kojem električna svojstva poluvodiča mogu biti dopiranjem podešavana u ogromnom rasponu. Visokoenergetska ozračavanja ionima se također mogu koristiti za kontroliranje svojstava materijala, ali putem inženjeringa defekata (tj. pomoću ionskih tragova). Ova vrsta zračenja je našla mnogobrojne primjene, npr. u proizvodnji membrana, hadronterapiji i istraživanjima skladištenja nuklearnog otpada.Cilj projekta je detaljno istraživanje defekata i njihove dinamike u naprednim materijalima tijekom zračenja visokoenergetskim ionima, a u svrhu da bi se odredili pogodni uvjeti za inženjering defekata. U fokusu su istraživanja defekata u grafenu i drugim izabranim 2D materijalima pomoću AFM/STM i Ramanove spektroskopije. Komplementarno ovom istraživanju bit će provedene studije o inženjeringu defekata putem visokoenergetskih ionskih snopova u drugim tehnološki važnim materijalima pomoću RBS/c-PIXE/c i AFM. Kako bi zadobili potpunu kontrolu nad defektima unesenim putem ionskih snopova, važno je razumijeti osnovne procese koji utječu na stvaranje defekata i njihovu dinamiku. Stoga, očekujemo da rezultati projekta pruže uvid u procese koji vladaju dinamikom defekata u naprednim materijalima tijekom zračenja ionima. Očekujemo da će rezultati projekta imati utjecaj na primjene poput senzora i katalizatora, putem novih funkcionalnih svojstava materijala dobivenih inženjeringom defekata. ]]></summary_hr><summary_en><![CDATA[Advanced materials and advanced materials processing techniques are basis of the present-day technology. Scientific advances initiated by recent discovery of graphene that captures many extraordinary properties in a single material promises unpreceded benefits that should justify disruption of current industrial processes, thus giving birth to radically new products. Clearly, to control properties of these new and exciting nanomaterials is of paramount importance for any kind of industrial application. Ion implantation is good example where electrical properties of semiconductors can be tuned in extraordinary wide range by ion doping. High energy ion irradiations can also be used to control materials properties, but in this instance control is achieved via defect engineering (i.e. ion tracks). This kind of irradiation has found many uses in diverse applications like track-etch-membrane production, hadron therapy, and nuclear waste storage studies.The aim of the project is to study in detail defects and their dynamics in advanced materials during high energy ion irradiation, in order to establish suitable conditions for defects engineering. In the research focus is defects analysis in graphene and other selected 2D materials using AFM/STM and Raman spectroscopy. Complementary to this research, studies of defects engineering by high energy ion beams in other technologically relevant materials using RBS/c-PIXE/c and AFM will be undertaken. To gain full control over defect engineering using ion beams, it is important to understand basic mechanisms governing defect production and their dynamics. Therefore, expected results of the project will provide insight into processes governing defect dynamics in advanced materials during ion irradiation. We expected project results to have impact on applications, like sensing and catalysis, due to new materials functionalities gained by defects engineering.]]></summary_en></project><project>
<id>8041</id><title_hr><![CDATA[Opterećenja vjetra i mora na energetske konstrukcije]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4960</user_id><user_firstLast_name>Hrvoje Kozmar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-1200</code><acronim><![CDATA[WESLO]]></acronim><duration>15.11.2019 - 16.02.2026</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, </scie_field_hr><scie_field_en>Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>29416</team_members_id><team_members_names><![CDATA[ Doktorand: Petar Škvorc ]]></team_members_names><keywords_hr><![CDATA[Inženjerstvo vjetra, aerodinamika okoliša, vjetar i konstrukcije, opterećenja mora, vjetroturbina, pučinska konstrukcija, zračni tunel]]></keywords_hr><keywords_en><![CDATA[Wind engineering, environmental aerodynamics, wind and structures, sea loads, wind turbine, offshore structure, wind tunnel]]></keywords_en><summary_hr><![CDATA[Vjetroturbine i pučinske platforme su izložene ekstremnim vremenskim uvjetima uključujući djelovanje vjetra, mora i valova. Da bi se produljio njihov vijek trajanja i povećala učinkovitost nužno je pažljivo analizirati utjecaje opterećenja okoliša na te objekte i predložiti odgovarajuća inženjerska rješenja. Uočeno je da su opterećenja vjetra, valova i mora na pučinske energetske objekte prethodno uglavnom bila analizirana odvojeno. Također se aerodinamička opterećenja na vjetroturbine u blizini brdovite obale i otoka bitno razlikuju od opterećenja na ravnom terenu i otvorenoj pučini, a karakteristike mahovitih vjetrova su u velikoj mjeri nepoznate u inženjerskim krugovima. Uz modelska laboratorijska ispitivanja, važan alat predstavljaju i računalne simulacije, u kojima trenutno nije moguće adekvatno reproducirati karakteristike atmosferske turbulencije. Sukladno navedenom vrlo aktualne istraživačke teme su: a) karakterizacija ekstremnih opterećenja i odziva vjetroturbina i platformi istovremeno uzrokovanih vjetrom, valovima i morskim strujama, b) aerodinamička opterećenja vjetroturbina u blizini brdovitog terena, c) karakteristike turbulencije mahovitog vjetra bure u obliku prikladnom za inženjersko projektiranje konstrukcija, d) metodologija računalne simulacije atmosferskog graničnog sloja i primjena na proračun opterećenja vjetroturbina i platformi. Da bi se navedeni ciljevi u potpunosti ostvarili u radu će biti korištene napredne istraživačke metode uključujući mjerenja u prirodi, laboratorijske eksperimente, računalnu mehaniku i dinamiku fluida. Budući da se integralna opterećenja vjetra, valova i morskih struja na energetske konstrukcije u potpunosti mogu analizirati isključivo kroz suradnju različitih grana znanosti i tehnike, istraživačka grupa u okviru ovog projekta na jedinstveni način uključuje stručnjake iz područja strojarstva, građevine, meteorologije i pomorske tehnike.]]></summary_hr><summary_en><![CDATA[Wind turbines and offshore platforms are exposed to a harsh marine environment including wind, wave and sea current loads. To extend their lifetime and increase energy production, it is necessary to carefully analyze effects of environmental loads on those structures and suggest appropriate engineering solutions. In the past, wind, wave and sea loads on offshore energy structures were commonly studied separately. In addition, aerodynamic loads on wind turbines close to hilly coast and islands are considerably different than the loads on wind turbines in flat terrain and open sea, whereas transient wind characteristics are fairly unknown to engineers. In addition to laboratory experiments, computational simulations are valuable tools to determine wind and sea loads on wind turbines and platforms. An important drawback with this approach at the moment is that it is not possible to completely accurately simulate characteristics of atmospheric turbulence. Hence, very contemporary research topics are: a) characterization of extreme loads and response of wind turbines and platforms simultaneously induced by wind, waves and sea currents, b) aerodynamic loads on wind turbines in complex terrain, c) characteristics of bora wind turbulence in a form usable for engineering design of structures, d) computational simulation methodology for the atmospheric boundary layer and application on wind-turbine and platform loads. To achieve those goals, various advanced research tools will be used including field measurements, small-scale laboratory experiments, computational mechanics and fluid dynamics. As integral wind, wave and sea current loads on energy structures can be completely analyzed only in case different engineering/science disciplines are involved, the research group on this project uniquely includes experts from mechanical and civil engineering, meteorology and offshore engineering in a unique blend of disciplines.]]></summary_en></project><project>
<id>8042</id><title_hr><![CDATA[Uloga unutarstaničnog života Francisella tularensis u patogenezi eksperimentalne tularemije]]></title_hr><title_en><![CDATA[]]></title_en><user_id>114</user_id><user_firstLast_name>Marina Šantić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-5858</code><acronim><![CDATA[FRANCYCLE]]></acronim><duration>16.04.2019 - 15.12.2023</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Medicine]]></institution_en><team_members_id>27882</team_members_id><team_members_names><![CDATA[ Doktorand: Maša Knežević ]]></team_members_names><keywords_hr><![CDATA[Francisella, FPO, sazrijavanje fagosoma/vakuole, autofagija, in vitro, in vivo]]></keywords_hr><keywords_en><![CDATA[Francisella, FPI, phagosome/vacuole maturation, autophagy, in vitro, in vivo]]></keywords_en><summary_hr><![CDATA[Francisella tularensis je gram-negativna, visoko infektivna, fakultativno unutarstanična bakterija koja uzrokuje tularemiju. Unutarstanični život F. tularensis je jedinstven u odnosu na druge unutarstanične bakterije. Fagosom koji sadrži francizelu (FCP - Francisella containing phagosome) zaustavljen je u fazi kasnog nezakiseljenog endosoma, nakon čega slijedi postupni bakterijski izlazak u citosol. Očito je da Francisella kruži kroz različite unutarstanične odjeljke; FCP i vakuolu koja sadrži francizelu (FCV – Franicisella containing vacuole). Zbog važnosti ovih staničnih odjeljaka u uspostavi i održavanju infekcije, po prvi put ćemo izolirati FCP i FCV iz makrofaga. Ovo je potpuno novi pristup u razumijevanju njihove uloge u unutarstaničnom životu francizela. Nadalje, pretpostavljamo da se značajni dio interakcije sa citosolom domaćina ostvaruje putem autofagije. Moguće je da, u kasnijoj fazi infekcije, Francisella oblikuje oštećenu FCV u autofagnu vakuolu. Brojna su istraživanja usredotočena na dio bakterijskog genoma poznatijem kao Francizela patogeni otok (FPO). Mnoge FPO mutante pokazuju jednoobrazan fenotip karakteriziran nemogućnošću bijega iz fagosoma, izostankom unutarstanične replikacije te gubitkom virulencije in vivo. Želimo dokazati da su FPO proteini (PdpC, IglC, IglI, PdpE i IglG) koji su efektori tipa VI sekrecijskog sustava uključeni u regulaciju procesa autofagije. Autofagija se smatra jednim od efektorskih mehanizama urođene imunosti protiv unutarstaničnih bakterija. Podaci o ulozi autofagije u regulaciji citokinske mreže tijekom tularemije su još uvijek rijetki i proturječni. Stoga bi naša daljnja istraživanja, posebno u modelu Atg5 transgeničnih miševa, trebala pridonijeti boljem razumijevanju autofagije kao imunom odgovoru na infekciju francizelom. Očekivani rezultati doprinijet će rasvjetljavanju patogeneze tularemije te pridonijeti razvoju novih terapijskih i preventivnih strategija baziranih na autofagiji.]]></summary_hr><summary_en><![CDATA[Francisella tularensis is a highly virulent facultative intracellular pathogen that causes  disease tularemia. The intracellular lifestyle of F. tularensis is unique compared to other intracellular pathogens. The Francisella-containing phagosome (FCP) is arrested at a non-acidified late endosome-like stage, which is followed by gradual bacterial escape into the cytosol. It is obvious that Francisella cycles through different intracellular compartments; FCP and the Francisella-containing vacuole (FCV). Because of the importance of these subcellular compartments during infection, we will establish a novel method of isolating the FCP/FCV from macrophages. This is an innovative approach in understanding their role in Francisella intracellular life cycle. Secondly, we proposed that the great part of communication with the host cytosol environment is accomplished by autophagy. We assume that Francisella reseal damaged FCV into the autophagic vacuole later during the infection. Many studies have been focused on a genomic region called the Francisella pathogenicity island (FPI). Some of the FPI mutants show a uniform phenotype characterized by lack of phagosomal escape, no intracellular replication, and a loss of virulence in vivo. We expect to find that FPI proteins, PdpC, IglC, IglI, PdpE, and IglG that are effectors of the type VI secretion system are also involved in manipulation of autophagy machinery. Autophagy is regarded as one of the innate immunity effectors against intracellular bacteria. However, the data on the role of autophagy in the regulation of cytokine networks by Francisella are still unknown. We propose a new concept using transgenic Atg5 mouse that should contribute to a better understanding of autophagy as host immune response to Francisella infections. The project will contribute to understanding the pathogenesis of tularemia, providing opportunities for the development of novel autophagy-based therapeutic and preventive strategies.]]></summary_en></project><project>
<id>8044</id><title_hr><![CDATA[Primjena inovativnih tehnika ekstrakcije bioaktivnih komponenti iz nusproizvoda biljnoga podrijetla]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3836</user_id><user_firstLast_name>Stela Jokić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-4340</code><acronim><![CDATA[ByProExtract]]></acronim><duration>15.02.2019 - 15.04.2023</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Prehrambena tehnologija, </scie_field_hr><scie_field_en>Food technology, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Prehrambeno-tehnološki fakultet]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Food Technology]]></institution_en><team_members_id>25722</team_members_id><team_members_names><![CDATA[ Doktorand: Silvija Šafranko ]]></team_members_names><keywords_hr><![CDATA[ekstrakcija, zelene tehnologije, bioaktivne komponente, nusproizvod, optimizacija]]></keywords_hr><keywords_en><![CDATA[extraction, green technologies, bioactive components, byproduct, optimization]]></keywords_en><summary_hr><![CDATA[Cilj svake proizvodnje (industrije) je dobivanje kvalitetnog proizvoda, uz što bolje iskorištenje sirovine. Tijekom prerade sirovine nastaje određena količina nusproizvoda koji nužno ne moraju biti otpad i “problem” nego visokovrijedna sirovina za razvoj novih proizvoda. Kakao ljuska, otpad iz proizvodnje duhana i kore citrusa su nusproizvodi koji nastaju u velikim količinama i  koji su još uvijek nedovoljno istraženi i iskorišteni unatoč sadržaju značajnih korisnih tvari. Cilj ovog projekta je proizvodnja ekstrakata iz navedenih nusprozvoda primjenom šest inovativnih zelenih ekstrakcijskih tehnika: superkritične fluidne ekstrakcije, ekstrakcije vodom u supkritičnom stanju, ekstrakcije potpomognute mikrovalovima, ekstrakcije potpomognute ultrazvukom, ekstrakcije potpomognute hladnom plazmom i ekstrakcije eutektičkim otapalima. U određivanju ciljanih bioaktivnih komponenti iz odabranih nusproizvoda primjenit će se visokosofisticirane kromatografske tehnike. Zbog velike raznolikosti bioaktivnih komponenti iz odabranih nusproizvoda, za svaku primijenjenu tehniku ekstrakcije definirat će se optimalni procesni parametri primjenom metode odzivnih površina. Ekstrakti s najvećim biološkim potencijalom će se postupkom sušenja raspršivanjem prevesti u praškasti oblik s potencijalnom komercijalnom primjenom.Rezultati istraživanja doprinjeti će rješenju problema velikih količina organskog otpada koji predstavlja ogroman ekološki i financijski teret u svim segmentima procesne industrije. Naglasak projekta je na potencijalnoj komercijalnoj valorizaciji rezultata istraživanja i transferu dobivenih rezultata u industriju, kao i na jačanju veze akademske zajednice s industrijom s ciljem ekonomskog razvoja i boljitka cijelog društva.]]></summary_hr><summary_en><![CDATA[All industries aim to obtain a quality product and to utilise raw materials as efficiently as possible in the production process. During the processing of raw materials, a certain amount of by-products is produced, which does not necessarily have to be “waste”, but a by-product or high value raw material for development of new products. Cocoa shells, tobacco waste, and citrus peels, are by-products produced in large quantities which are usually underutilized or considered as waste, in spite of the fact that they contain different classes of useful components. The aim of this project is to obtain extracts rich in bioactive components from selected by-products using six innovative green extraction techniques: supercritical fluid extraction (SFE), subcritical water extraction (SWE), microwave-assisted extraction (MAE), ultrasound-assisted extraction (UAE), cold atmospheric plasma assisted extraction (CAPAE), and extraction using deep eutectic solvents (DES). Determination and isolation of bioactive components from selected by-products will be performed using highly sophisticated chromatographic techniques. Due to great diversity of bioactive components from diverse material, optimal extraction conditions will be defined for each applied technique by using response surface methodology (RSM). Extracts with the highest biological potential will be dried by using spray drying technology in order to produce plant powders with potential commercial application. The results of the research will contribute to solving the problem of large quantities of organic waste, which represents an enormous ecological and financial burden for all aspects of the process industry. Special emphasis in the project will be put on the possible commercial valorisation of the research results and on the transfer of those results to the application level, as well as on strengthening the relationship between the academic community and the industry.]]></summary_en></project><project>
<id>8045</id><title_hr><![CDATA[Višegodišnje i dekadne oscilacije Jadranskog mora: opažanja, modeliranje  i posljedice]]></title_hr><title_en><![CDATA[]]></title_en><user_id>195</user_id><user_firstLast_name>Ivica Vilibić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-2771</code><acronim><![CDATA[ADIOS]]></acronim><duration>01.06.2019 - 29.02.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Geofizika, </scie_field_hr><scie_field_en>Geophysics, </scie_field_en><institution_hr><![CDATA[Institut za oceanografiju i ribarstvo]]></institution_hr><institution_en><![CDATA[Institute of Oceanography and Fisheries]]></institution_en><team_members_id>28651</team_members_id><team_members_names><![CDATA[ Doktorand: Petra Pranić ]]></team_members_names><keywords_hr><![CDATA[Jadransko more, višegodišnje i dekadske oscilacije, stvaranje guste vode, BIOS, združeno klimatsko modeliranje atmosfere i mora]]></keywords_hr><keywords_en><![CDATA[Adriatic Sea, interannual and decadal oscillations, dense water formation, BIOS regimes, coupled atmosphere/ocean climate modelling]]></keywords_en><summary_hr><![CDATA[Glavni cilj projekta Adios je istražiti i kvantificirati procese koji pogone međugodišnje i desetljetne termohaline varijacije u jadransko-jonskom bazenu. Cilj će se postići (i) dokumentiranjem međugodišnje i desetljetne varijabilnosti analizom dugoročnih oceanografskih mjerenja i postojećih klimatskih modela, (ii) istraživanjem kratkoročnih i dugogodišnjih procesa koji pokreću jadransko-jonsku termohalinu cirkulaciju, u prvom redu stvaranje guste vode u Jadranu i BIOS-a (Bimodalna jadransko-jonska oscilacija), i (iii) procjenom prošle i buduće jadranske klime i varijabilnosti primjenom jadranskog združenog (atmosfera-more) klimatskog modela visoke razlučivosti. Iako se odavno zna da je međugodišnja i desetljetna termohalina promjenjivost dominantna u Jadranu, odgovarajuća teorija (BIOS) razvijena je tek nedavno, te još uvijek nije ispravno reproducirana od strane oceanskih numeričkih modela. Stoga će se u okviru ADIOS projekta postaviti i pokrenuti ugniježđeni združeni klimatski model visoke rezolucije u području Jadrana. Nakon verifikacije nad mjerenjima, model će se primijeniti na buduću klimu koristeći nekoliko IPCC scenarija. Takav pristup omogućit će preciznu procjenu budućih klimatskih promjena na Jadranu, uključujući i višegodišnju i desetljetnu varijabilnost i regulirajuće procese, što će biti temelj za procjenu klimatskih rizika na nacionalnoj i regionalnoj razini. Značajan projektni napor će se posvetiti nastavku mjerenja na Palagruškom oceanografskom profilu, najdužem sezonski uzorkovanom oceanografskom transektu na Sredozemlju u trajanju od oko 60 godina, ali vrlo rijetko uzorkovanom nakon 2013. godine. ADIOS projekt će imati snažnu međunarodnu komponentu koja uključuje priznate oceanografske institute (OGS, CNRS-GAME), te njihove istraživače aktivno uključene na predviđena projektna istraživanja, što će rezultirati povećanjem kapaciteta, umreženosti i učinkovitosti hrvatske oceanografske i klimatske zajednice.]]></summary_hr><summary_en><![CDATA[The major objective of the ADIOS project is to investigate and to quantify processes driving interannual to decadal thermohaline variations in the Adriatic-Ionian basin. This objective will be achieved by (i) documenting interannual to decadal variability from long-term oceanographic series and existing climate models, (ii) investigating short- and long-time processes that drive the Adriatic-Ionian thermohaline circulation, primarily the Adriatic dense water formation and the BiOS (Adriatic-Ionian Bimodal Oscillating System), and (iii) assessing past and future Adriatic climate and variability from the Adriatic-adopted high-resolution atmosphere/ocean climate model runs. Although interannual to decadal thermohaline variability is known to be dominant in the Adriatic, the respective theory (cf. BIOS) has been developed very recently and is still not properly reproduced and verified by ocean numerical models. To tackle this, the Adriatic climate run will be setup and executed through nesting of state-of-the-art high-resolution atmospheric/ocean models into the Mediterranean runs. Once validated for a 30 year hindcast time period, the Adriatic model will be used in forecast mode for several IPCC scenarios. Such an approach will allow for better assessment of future climate changes in the Adriatic, including interannual to decadal variability and governing processes. These simulations will be a base for an upgrade in climate hazard assessment on national and basin levels. A significant project effort will be dedicated to continuation of the Palagruža Sill oceanographic transect, the longest seasonally-sampled transect in the Mediterranean, lasting over 60 years but very sparsely sampled since 2013. The project will have a strong international component, incorporating recognized institutes (OGS, CNRS-GAME) and their researchers to the ADIOS research and therefore increasing capacities, networks and efficiency of the Croatian oceanographic and climate communities.]]></summary_en></project><project>
<id>8046</id><title_hr><![CDATA[Fitotoksičnost nanosrebra: mehanizmi akcije i interakcije u stanicama duhana]]></title_hr><title_en><![CDATA[]]></title_en><user_id>11303</user_id><user_firstLast_name>Biljana Balen</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-3722</code><acronim><![CDATA[NanoPhytoTox]]></acronim><duration>17.06.2019 - 16.12.2023</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>27557</team_members_id><team_members_names><![CDATA[ Doktorand: Karla Košpić ]]></team_members_names><keywords_hr><![CDATA[nanosrebro, biotransformacija, biomarkeri, stanična ultrastruktura, omotači, oksidacijski stress, proteomika, mehanizmi toksičnosti]]></keywords_hr><keywords_en><![CDATA[nanosilver, biotransformation, biomarkers, cell ultrastructure, coatings, tobacco, oxidative stress, proteomics, toxicity mechanisms]]></keywords_en><summary_hr><![CDATA[Male dimenzije nanočestica (NPs), rezultiraju jedinstvenim kemijskim i fizikalnim značajkama, zbog čega se one proizvode u velikim količinama i koriste u različitim proizvodima. Zbog široke upotrebe nanosrebra (AgNPs), najzastupljenijeg nanomaterijala koji ima protubakterijska i protugljivična svojstva, raste zabrinutost glede mogućih štetnih učinaka na okoliš. Do sada je objavljeno nekoliko toksikoloških studija na česticama AgNP, no još uvijek je teško donijeti konačne zaključke o njihovoj toksičnosti. AgNPs su sklone (bio)transformaciji, koja mijenja njihova svojstva i još uvijek nije jasno potječe li toksičnost od samih nanočestica ili od otpuštenih iona Ag+. Biljke kao vitalan dio ekološkog sustava imaju važnu ulogu u transportu i bioakumulaciji toksičnih tvari u hranidbeni lanac. No, studije fitotoksičnosti AgNP su malobrojne i manjkave. Nadalje, nedostaju i podaci o učincima AgNPs na važne stanične procese. Stoga u ovom projektu želimo otkriti i objasniti toksične učinke nekoliko različitih tipova AgNPs na biljke, što će doprinijeti procjeni okolišnog rizika izlaganja nanosrebru. Kao modelni organizam predlažemo duhan, ekonomski važnu biljku često korištenu u istraživanjima abiotičkog stresa. Testirat ćemo AgNPs stabilizirane različitim omotačima, kako bi otkrili utječu li različite osobine ovih nanočestica na njihovu toksičnost. Kako bismo ustanovili potječe li toksičnost AgNPs od oslobođenih iona Ag+ ili od samih nanočestica, odredit ćemo stabilnost i biotransformaciju AgNPs i ustanoviti ulaze li nanočestice u biljno tkivo odnosno stanicu. Nadalje, utvrdit ćemo ulogu oksidacijskog stresa u mehanizmu toksičnosti nanosrebra te dolazi li tijekom izlaganja nanosrebru do promjene u sastavu proteina. Na temelju dobivenih rezultata definirat ćemo biomarkere fitotoksičnosti AgNPs koji bi se mogli koristiti u biomonitoringu okoliša. Dobiveni rezultati moći će se primijeniti za procjenu sigurnosti korištenja nanočestica srebra.]]></summary_hr><summary_en><![CDATA[The small size of nanoparticles (NPs) results in unique chemical and physical characteristics, which is why they are produced in large quantities for implementation in various products. Due to widespread use of silver nanoparticles (AgNPs), the dominating nanomaterial with antibacterial and antifungal properties, there is a concern regarding its potential detrimental impacts on the environment. Although there have been a lot of toxicological studies published on AgNPs, it is still difficult to draw conclusions about their toxicity. AgNPs are prone to (bio)transformation, which modifies their properties and it is not clear whether toxicity results from the nanoparticles or from Ag+ dissociation. Besides being the vital part of healthy ecosystems, plants play a significant role in transport and bioaccumulation of toxic substances in food chains, but toxicological studies of AgNPs conducted on plants are scare and inconclusive. Moreover, there is a lack of information about effects of AgNPs on important cellular processes. Therefore, in this project we aim to reveal and explain the toxicity of a set of diverse AgNPs to plants in order to contribute to the environmental hazard assessment of AgNP. As the model organism we propose tobacco, an economically interesting plant, frequently used in stress research. We will investigate AgNPs with different coatings, used to enhance NP stability, to reveal whether those characteristics are determinants of toxicity. Stability and biotransformation of AgNPs as well as their uptake in the cells will be studied and correlated with AgNPs-induced effects to distinguish between particle and Ag+ toxicity. We will establish the involvement of oxidative stress in the mechanism of toxicity as well as possible proteomic changes. The results will be used to define biomarkers of AgNP-induced phytotoxicity, which could be useful for environmental biomonitoring. Also, results can be applied to estimate the possibility of use and safety of AgNPs.]]></summary_en></project><project>
<id>8047</id><title_hr><![CDATA[Razumijevanje zračenja na niskim radio frekvencijama: Ususret novoj generaciji radio teleskopa]]></title_hr><title_en><![CDATA[]]></title_en><user_id>19010</user_id><user_firstLast_name>Vibor Jelić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-9169</code><acronim><![CDATA[LowFreqCRO]]></acronim><duration>12.02.2019 - 12.08.2023</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>25785</team_members_id><team_members_names><![CDATA[ Doktorand: Luka Turić ]]></team_members_names><keywords_hr><![CDATA[radioastronomija, polarimetrija, međuzvjezdana materija, magnetska polja, ekstragalaktički radio izvori]]></keywords_hr><keywords_en><![CDATA[radioastronomy, polarimetry, interstellar medium, magnetic fields, extragalactic radio sources]]></keywords_en><summary_hr><![CDATA[Razumijevanje zračenja na niskim radio frekvencijama ključna je za traženje odgovora na brojna temeljna pitanja u astrofizici. Pomoću novih radio teleskopa osjetljivih na radio zračenje niskih radio frekvencija, znanstvenici bi trebali po prvi put detektirati kozmološko zračenje iz perioda nastanka prvih zvijezda u svemiru, staro nekoliko milijardi godina. Ova vrlo duboka opažanja neće samo otkriti kada i gdje su prvi izvori formirani u ranom svemiru započeli ionizirati pretežno neutralnu sve prožimajuću materiju, već će pružiti visoko kvalitetne podatke za najsuvremeniju znanost zračenja iz prednjeg plana. Samo istraživanje fizike zračenja iz prednjeg plana, bilo galaktičkog ili ektragalaktičkog, je zanimljivo samo po sebi i igra ključnu ulogu u razvoju metoda za eliminaciju zračenja iz prednjeg plana u kozmološkim eksperimentima. Ovdje predlažemo najsuvremenije istraživanje zračenja iz prednjeg plana. Konkretnije, mi ćemo: (i) koristiti radio teleskopa LOFAR za detaljnu tomografiju (lokalne) međuzvjezdane materije (ISM) pomoću opažanja sinhrotronskog zračenja naše galaksije i njegove polarizacije; (ii) kombinirati radio-opažanja s drugim promatranjima (npr. HI, H?, prašina, GRB, zvijezde itd.) kako bi istražili povezanost Faradejevih struktura s ostalim fazama ISMa i njihove povezanost s međuzvjezdanim magnetskim poljima; (iii) izraditi novi model polariziranog zračenja naše Galaksije baziran na LOFARovim promatranjima, a koji će se koristiti za razvoj tehnika uklanjanja zračenja iz prednjeg plana; i (iv) simulacije ekstragalaktičkih radio izvora na temelju rezultata Cosmic Evolution Survey (COSMOS). Financiranje predloženog istraživanja bit će ključno za razvoj    hrvatske astrofizike na međunarodno kompetitivnoj razini, te će rezultati predloženog istraživanja otvoriti put prema ključnim znanstvenim projektima novih generacija radio teleskopa (npr. Square Kilometer Array). ]]></summary_hr><summary_en><![CDATA[Understanding foreground emission at low radio frequencies touches upon many fundamental questions in astrophysics. With the novel low-frequency radio telescopes researchers are expected to detect cosmological radiation emitted billions of years ago, from the time of the first “stars”. These very deep observations will not only set constraints on when and where the first sources formed in the early Universe and began (re)ionizing the predominantly neutral all-pervasive intergalactic medium, but they are also providing high-quality data for cutting edge auxiliary foreground science. Obviously studying the physical origin of the foregrounds, whether Galactic or extragalactic, is a very exciting field in its own right and is of fundamental importance for perfecting the foreground removal techniques in the cosmological experiments. Here, we propose the state-of-the-art study of the foreground emission. In particular, we will: (i) use the novel capabilities of the Low Frequency Array (LOFAR) radio telescope to conduct the detailed tomography of the local interstellar medium (ISM) by observing Galactic synchrotron emission and its polarization; (ii) combine these radio observations with other observational probes (e.g. HI, H?, dust, GRB afterglows, close-by stars, etc.) to investigate the association of Faraday structures with different ISM phases and association with the interstellar magnetic fields; (iii) built new data driven model of Galactic polarized emission that will be used for development of the foreground removal techniques; and (iv) simulations of extragalactic radio sources, based on the Cosmic Evolution Survey (COSMOS) results. Funding of the proposed research is essential to keep Croatian astrophysics at an internationally competitive level and go beyond this by providing results that will pave the way for the key science cases of the next generation of radio telescopes (e.g. Square Kilometer Array). ]]></summary_en></project><project>
<id>8048</id><title_hr><![CDATA[Rasvijetljavanje mehanizama rezistencije na terapiju raka debelog crijeva sa mutacijom BRAF pomoću integriranog -omics pristupa]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3261</user_id><user_firstLast_name>Mirela Sedić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-4454</code><acronim><![CDATA[BRAFCON]]></acronim><duration>04.03.2019 - 03.09.2023</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Interdisciplinarno područje znanosti</scie_area_hr><scie_area_en>Interdisciplinary scientific area</scie_area_en><scie_field_hr>Biotehnologija u biomedicini, </scie_field_hr><scie_field_en>Biotechnology in Biomedicine, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Fakultet biotehnologije i razvoja lijekova]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Biotechnology and Drug Development]]></institution_en><team_members_id>28696</team_members_id><team_members_names><![CDATA[ Doktorand: Iris Car ]]></team_members_names><keywords_hr><![CDATA[BRAF, rak debelog crijeva, kemorezistencija, proteomika, sfingolipidomika, sektretom stanica raka]]></keywords_hr><keywords_en><![CDATA[BRAF, colon cancer, chemoresistance, proteomics, sphingolipidomics, cancer secretome]]></keywords_en><summary_hr><![CDATA[Kolorektalni karcinom (CRC) je treće po redu najčešće dijagnosticirano maligno oboljenje i četvrti vodeći uzrok smrtnosti povezane s rakom na globalnoj razini. Zahvaljujući naprecima u sistemskoj kemoterapiji, ciljanim terapijama i kirurškim tehnikama, preživljenje pacijenata s metastatskim CRC se poboljšalo u posljednja dva desetljeća. Unatoč tome, napreci u terapiji nisu unaprijedili liječenje svih molekularnih podtipova CRC. Ovo se naročito odnosi na populaciju CRC pacijenata sa BRAFV600E mutacijom (7–10%) koji slabo odgovaraju na većinu sistemske terapije i imaju vrlo lošu prognozu. Vemurafenib, protein kinazni inhibitor BRAFV600E kojeg je FDA odobrila za liječenje metastatskog melanoma sa BRAFV600E mutacijom, unio je nadu u liječenje BRAF-mutiranog CRC. Međutim, suprotno rezultatima dobivenim kod melanoma sa BRAFV600E mutacijom, monoterapija vemurafenibom je pokazala limitiranu kliničku učinkovitost u CRC pacijenata sa BRAFV600E mutacijom. Kako bi se poboljšali ishodi liječenja CRC pacijenata sa BRAFV600E mutacijom, potrebno je bolje razumjeti mehanizme rezistencije na BRAF inhibitore. Projekt BRAFCON će rasvijetliti procese koji vode ka razvoju rezistencije na BRAF inhibiciju vemurafenibom u stanicama raka debelog crijeva sa BRAFV600E mutacijom tako što će omogućiti integraciju različitih slojeva molekularne informacije (proteom, glikoproteom, sekretom i sfingolipidom) uzevši u obzir složenu interakciju između molekularnih signala unutar i izvan stanica raka debelog crijeva koji utječu na brojne aspekte staničnog ponašanja. Bioinformatička analiza i integracija –omics podataka će otkriti nove markere i mete rezistencije omogućujući tako dizajniranje nove kombinirane strategije za prevladavanje terapijske rezistencije na vemurafenib koja će potom biti validirana in vitro. Na taj će način BRAFCON doprinjeti razvoju novih modaliteta liječenja oboljelih od raka debelog crijeva sa BRAF mutacijom. ]]></summary_hr><summary_en><![CDATA[Colorectal cancer (CRC) is the third most commonly diagnosed malignancy and the fourth leading cause of cancer-related deaths in the world. Owing to the improvements in systemic chemotherapy, targeted therapies and surgical techniques, the survival of patients with metastatic CRC (mCRC) has improved over the past two decades. Still, these therapeutic advances have not brought benefit to all molecular subtypes of CRC. This particularly holds true for the population of mCRC patients with BRAFV600E mutation (7–10%) which have poor response to most systemic therapies and a very poor prognosis. Vemurafenib, a protein kinase inhibitor of BRAFV600E approved by the FDA for the treatment of metastatic melanoma with BRAFV600E mutation, has raised hopes of treatment for BRAF-mutant CRC. However, opposite to the results seen in patients with BRAFV600E mutant melanoma, single-agent vemurafenib exerted limited clinical efficacy in patients with BRAFV600E mutant CRC. In order to improve outcomes in CRC patients with BRAF mutation, there is a critical need to better understand the mechanisms of resistance to BRAF inhibitors. The BRAFCON project strives to give a new perspective on the processes governing acquired resistance to BRAF inhibition by vemurafenib in BRAFV600E mutant colon cancer cells by integrating different layers of molecular information (proteome, glycoproteome, secretome and sphingolipidome) while taking into account an intricate interplay of molecular signals both, inside and outside of colon cancer cells that influence multiple aspects of cell behaviour.  Bioinformatics analysis and integration of –omics data would reveal novel resistance markers and targets guiding the design of new combinatorial strategy to counter therapeutic resistance to vemurafenib in BRAF-mutant colon cancer cells, which will be validated in vitro. In this way, BRAFCON will contribute to the development of new treatment modalities for BRAF-mutant colon cancer patients.  ]]></summary_en></project><project>
<id>8049</id><title_hr><![CDATA[Glikozilacija alfa kiselog glikoproteina - put prema personaliziranoj terapiji]]></title_hr><title_en><![CDATA[]]></title_en><user_id>12360</user_id><user_firstLast_name>Mario Gabričević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-2878</code><acronim><![CDATA[GlycoDrugs]]></acronim><duration>15.04.2019 - 14.04.2023</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Farmaceutsko-biokemijski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Pharmacy and Biochemistry]]></institution_en><team_members_id>26516</team_members_id><team_members_names><![CDATA[ Doktorand: Tino Šeba ]]></team_members_names><keywords_hr><![CDATA[alfa kiseli glikoprotein, glikozilacija, konstanta vezanja lijeka, personalna terapija, lijekovi ]]></keywords_hr><keywords_en><![CDATA[alpha acid glycoprotein, glycosylation, drug binding constant, personally oriented therapy, drugs ]]></keywords_en><summary_hr><![CDATA[Nakon što se lijek aplicira u krv, on se najčešće u određenoj mjeri vezuje na proteine plazme. Važnost ovakvog vezanja je dobro opisana u literaturi, a udio vezanja pri ravnotežnim uvjetima određuje koncentraciju slobodnog lijeka. Slobodni udio lijeka je najčešće onaj koji je raspoloživ za aktivnost ili difuziju u okolna tkiva te se stoga samo nevezana frakcija lijeka smatra aktivnim oblikom, u skladu s “principom slobodnog lijeka”. Kao posljedica visoke koncentracije, proteini plazme kontroliraju koncentraciju slobodnog lijeka u plazmi, kao i u biološkim odjeljcima koji su s njom u ravnoteži, utječući na taj način na djelotvornost in vivo. U kliničkom smislu ovaj kapacitet treba se uzeti u obzir kad se određuje doza lijeka ili procjenjuje moguća toksičnost primijenjenog lijeka, što je obično dodatno usloženo uslijed promijena u kapacitetu proteina za vezanje lijeka kod određenih pacijenata. Izrazito glikozilirani alfa kiseli glikoprotein je jedan od dva proteina koji vežu veliki broj različitih lijekova i općenito utječu na djelotvornost lijekova. Postoje tri genetičke varijante i to F1, S i A. Vezanje lijekova za AGP može biti promijenjeno i u brojnim patološkim i fiziološkim stanjima kao rezultat promjene u glikozilacijskom uzorku. Ukupno gledano, tri faktora utječu na vezanje lijekova za AGP: Koncentracija AGP-a, omjer različitih genetičkih varijanti i promjene u glikozilacijskom uzorku. Ciljevi projekta su: 1. Kako različite genetičke varijante AGP-a utječu na ukupno vezanje lijekova? 2. Kakav je utjecaj promijenjenog glikozilacijskog uzorka na vezanje lijekova 3.  Predviđenje slobodnog udijela lijeka ovisno o navedena tri faktora. Koristit će se fizikalne metode kao fluorescencijska spektroskopija, ravnotežna dijaliza i masena spektroskopija kako bi se odredio utjecaj glikozilacijskih promjena AGP-a na vezanje lijekova i posljedično predvidio utjecaj te promjene na terapiju.]]></summary_hr><summary_en><![CDATA[After the administration of the drug to the blood stream, it often binds to a certain extent to plasma proteins. The importance of such plasma protein binding is a well recognized phenomenon and the extent of this association at equilibrium determines the concentration of unbound drug. Free fraction of the drug is most commonly the only one available for active uptake or diffusion into the surrounding tissue according to the “free drug principle”. Due to their high concentration, the plasma proteins control the free drug concentration in plasma thus influencing the drug potency in vivo. Clinically, this effect should be considered when adjusting the dosage of a drug, as well as in assessing the toxicity of the administered drug which is often complicated by changes in patient’s protein-binding capacity. Heavily glycosylated alpha-1-acid glycoprotein (AGP) is one of two proteins present in sufficient quantity to bind a broad variety of drugs and generally has a significant effect on drug action. Adding to complexity, human AGP exists as a heterogeneous population of three genetic variants namely F1, S and A. Importantly, drug binding to the AGP may be altered in numerous pathological and physiological states as a result of changes in glycosylation pattern. Overall, there are three major factors influencing binding of drugs to AGP: Concentration of AGP, ratio of different genetic forms and changes in glycosylation. Goals of this project are: 1. How different genetic forms of native AGP influence the overall drug binding? 2. What is the influence of changed glycosylation patterns of AGP on drug binding? 3. “Free drug” prediction dependent on mentioned three factors. We will use physical methods like fluorescence spectroscopy, equilibrium dialysis and MS to evaluate influence of AGP glycosylation change on drug binding and subsequently predict influence on drug therapy.]]></summary_en></project><project>
<id>8050</id><title_hr><![CDATA[Makrozoni, novi konjugati makrolidnih antibiotika: Dizajn, priprava i interakcije]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1106</user_id><user_firstLast_name>Predrag Novak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-6675</code><acronim><![CDATA[Makrozoni/Macrozones]]></acronim><duration>14.03.2019 - 13.03.2023</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>28650</team_members_id><team_members_names><![CDATA[ Doktorand: Ivana Mikulandra ]]></team_members_names><keywords_hr><![CDATA[makrozoni, dizajn, priprava, bioaktivnost, interakcije]]></keywords_hr><keywords_en><![CDATA[macrozones, design, synthesis, bioactivity, interactions]]></keywords_en><summary_hr><![CDATA[Porast bakterijske rezistencije na postojeće antibiotike danas predstavlja vrlo ozbiljan globalni problem u čije se rješavanje uključila i svjetska zdravstvena organizacija WHO. Zabrinjavajuća je činjenica da je u posljednjih desetak godina otkriveno svega nekoliko novih antibiotika što uskoro za posljedicu može imati povećanu smrtnost čak i od običnih infekcija. Stoga je potrebno uložiti znatne napore u istraživanja koja imaju za cilj prevladavanje bakterijske rezistencije. Naši preliminarni rezultati su pokazali da postoji veliki potencijal za istraživanje konjugata makrolidnih antibiotika. Sukladno tome, cilj predloženog projekta je dizajn, priprava i interakcije makrozona, novih bioaktivnih konjugata makrolidnih antibiotika i tiosemikarbazona. Planirana istraživanja uključujuju: sintezu konjugata njihovim povezivanjem na odabranim ključnim mjestima; određivanje njihove strukture i karakterizaciju u čvrstom stanju i otopini; istraživanje njihove stabilnosti i interakcija s biološkim metama; biološka ispitivanja i određivanje odnosa strukture i biološke aktivnosti kao preduvjet za dizajn novih bioaktivnih spojeva. Važnost istraživanja je i u činjenici da će sustavno određivanje odnosa kemijske strukture i biološke aktivnosti, s naglaskom na utjecaju položaja tiosemikarbazonskog supstituenta, na promjenu bioloških svojstava i vezanja na biološku metu dati nove spoznaje i omogućiti razvoj bioaktivnih spojeva. Očekuje se da će suradnja znanstvenika u predloženim interdisplinarnim istraživanjima stvoriti centar izvrsnosti u ovom području znanosti, čime će se proširiti i baza ekspertize u području medicinske kemije i otkrića novih antibiotika. Rezultati koji se očekuju u sklopu predloženog projekta omogućit će stjecanje novih znanja s mogućnošću patentiranja i praktične primjene u zdravstvu i farmaceutskoj industriji. ]]></summary_hr><summary_en><![CDATA[Emerging multi-drug resistant microbes present today a serious and challenging global problem which demand novel antimicrobial agents to be discovered. The WHO has recognized the threat and issued recently a report warning that even minor injuries could become lethal. In the last ten years just nine new antibiotics have been approved which was significantly less than decades before and not enough new ones are being developed to counter resistance. Our preliminary result have shown a great antibacterial potential of new macrolide antibiotic conjugates, the macrozones. Hence, the main objective of the proposed project is design, preparation and interactions of new classes of bioactive macrolide antibiotic conjugates by linking azithromycin and clarithromycin to thiosemicarbazone at key positions. The proposed rearch is interdisciplinary since it includes a) preparation of new conjugates, b) their complete characterisation in solution and solid state, c) evaluation of their biological properties and interactions with biological receptors and d) establishing structure activity relationships as a basis for design of molecules with better biological activity. The importance of this project also lies in the fact that establishing structure-activity relationships by systematic determination of influence of the position of thiosemicarbazone moiety at azalide/macrolide ring to antimicrobial activity will provide new insights into their binding and enable new bioactive molecules to be discovered. By joining different expert teams from synthetic and structural chemistry to biology and medicine this project will benefit and we expect that it will provide new scientific discoveries and knowledge that can further be exploited in practice to develop medical products based on high technology. We believe that investigations performed in the project and the cooperation of research groups will create centre of excellence in the field of medicinal chemistry and antibiotic drug design.]]></summary_en></project><project>
<id>8051</id><title_hr><![CDATA[Molekularni biljezi vulnerabilnosti, adaptacije i plastičnosti neurona u akutnoj i kroničnoj ozljedi mozga]]></title_hr><title_en><![CDATA[]]></title_en><user_id>12492</user_id><user_firstLast_name>Kristina Mlinac Jerković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-7900</code><acronim><![CDATA[NeuroReact]]></acronim><duration>06.05.2019 - 04.11.2023</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>26530</team_members_id><team_members_names><![CDATA[ Doktorand: Borna Puljko ]]></team_members_names><keywords_hr><![CDATA[selektivna vulnerabilnost neurona, hipokampus, mali mozak, glikolipidom, plastičnost, neurodegeneracija]]></keywords_hr><keywords_en><![CDATA[selective neuronal vulnerability, hippocampus, cerebellum, glycolipidome, plasticity, neurodegeneration]]></keywords_en><summary_hr><![CDATA[Više od 165 milijuna ljudi u Europi boluje od poremećaja koji zahvaćaju živčani sustav. Izrazito opterećenje za bolesnika i zdravstveni sustav predstavljaju bolesti kojima je zajednička neurodegeneracija. Neuroni pokazuju selektivnu vulnerabilnost, a intrigantna je razlika u odgovoru na raznovrsne nokse između velikog i malog mozga. Naša je hipoteza da različiti tipovi stanica u mozgu sadrže prepoznatljiv molekularni „potpis“ koji ih čini više ili manje osjetljivima i koji sudjeluje u odgovoru na patološki proces. Cilj projekta je utvrditi u kolikoj mjeri su za selektivnu vulnerabilnost neurona odgovorni zajednički učinci ekspresije određenih proteina i njihovog lipidnog miljea, odnosno postoje li specifične promjene sastava i ekspresije membranskih glikolipida i proteina koje se mogu povezati s patogenezom neurodegeneracije u stanjima akutne i kronične ozljede mozga. Fokusirat ćemo se na analizu neurona hipokampusa i malog mozga u stanjima hiperekscitabilnosti, hipoksične lezije i Alzheimerovoj bolesti. U istraživanju će biti korišteni ljudski uzorci, tkivo mišjih modela i stanični model, čiji će specifični glikolipidomski profili biti povezani s rezultatima transkriptomske, proteomske, elektrofiziološke i morfološke analize. Projekt je nastavak naših istraživanja koja su dokazala: promjene sastava i metabolizma gangliozida u Alzheimerovoj bolesti u mozgu i perifernim tkivima; utjecaj sastava moždanih gangliozida na ekspresiju membranskih proteina uključenih u sinaptičku plastičnost i transport iona, u mišjem modelu čijim fenotipom dominira degeneracija aksona i sklonost konvulzijama. U ovoj studiji ćemo usporediti ekspresiju glikolipida i izabranih proteina u dvije regije mozga s različitim odgovorom na neurodegeneraciju, stoga očekujemo da će istraživanje olakšati prepoznavanje specifičnih molekularnih biljega vulnerabilnosti i adaptacije neurona. Hipotetski je moguće modulirati aktivnost molekula-biljega i pospješiti funkcionalnu prilagodbu tkiva na ozljedu.  ]]></summary_hr><summary_en><![CDATA[Nervous system disorders affect more than 165 million people in Europe. Diseases sharing neurodegeneration as a common pathological feature present a particularly big burden for patients and public health. Neurons are selectively vulnerable and there is intriguing difference between cerebral and cerebellar neurons responding to pathological stimuli. We hypothesize that different neuronal types contain recognizable molecular “signature” making them more or less susceptible and which is involved in tissue response to lesion. The aim of the project is to estimate combined effects of specific membrane proteins expression and their lipid environment on selective neuronal vulnerability, i.e. to determine whether specific changes in membrane glycolipid and protein composition and expression may be related to neurodegenerative pathogenic events. We will focus on the analysis of hippocampal and cerebellar neurons affected by hyperexcitability, hypoxia and Alzheimer’s disease. Glycolipidomic profile of selected regions derived from human and mouse models brain and cellular model will be associated with results of detailed transcriptomic, proteomic, electrophysiological and morphological analysis. Project is based on our previous research showing: changes of ganglioside composition and metabolism in brain and peripheral tissues in Alzheimer’s disease; influence of brain ganglioside composition on expression of membrane proteins involved in synaptic plasticity and ion transport in mouse model with phenotype characterized by axonal degeneration and susceptibility to convulsions. In this study, we will compare the expression of glycolipids and selected proteins in two brain regions responding/reacting differently to neurodegeneration. We expect that such an approach will enable recognition of specific molecular markers of neuronal vulnerability and adaptation. Hypothetically, modulating the activity of these molecular markers may contribute to functional tissue adaptation.]]></summary_en></project><project>
<id>8052</id><title_hr><![CDATA[Analiza interakcija butirilkolinesteraze s novim inhibitorima i reaktivatorima ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>872</user_id><user_firstLast_name>Zrinka Kovarik</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-7257</code><acronim><![CDATA[AnalyseBChE]]></acronim><duration>04.02.2019 - 02.06.2023</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut za medicinska istraživanja i medicinu rada]]></institution_hr><institution_en><![CDATA[Institute for Medical Research and Occupational Health]]></institution_en><team_members_id>28637</team_members_id><team_members_names><![CDATA[ Doktorand: Tena Cadez Cadez ]]></team_members_names><keywords_hr><![CDATA[acetilkolinesteraza, butirilkolinesteraza, bojni otrovi, inačice, kinetika]]></keywords_hr><keywords_en><![CDATA[acetylcholinesterase, butyrylcholinesterase, bioscavengers, variants, nerve agents, kinetics]]></keywords_en><summary_hr><![CDATA[Inhibicija ljudske butirilkolinesteraze (BChE) vezanjem spojeva na katalitički serin ima iznimnu ulogu u detoksikaciji i zaštiti organizma od ksenobiotika kao što su organofosfati (OP) te u metabolizmu lijekova kao što su karbamat bambuterol i fenotiazin etopropazin. Međutim, unatoč ovoj važnoj ulozi BChE, proučavanje kinetike tog enzima uglavnom je vezano uz istraživanje srodnog enzima acetilkolinesteraze (AChE) ključne za prijenos živčanih impulsa. Štoviše, reaktivatori inhibirane BChE, kao i lijekovi koji se koriste za liječenje neurodegenerativnih bolesti, sintetizirani su empirijski prije razriješenja kristalne strukture enzima. Zbog specifičnosti aktivnog mjesta BChE afinitet enzima te inhibicija i brzina reaktivacije nisu do sada detaljno istražene. Isto tako naša istraživanja ukazuju da na brzinu reakcije reaktivacije značajno utječe dizajn eksperimenta te reakcije poput oksimolize i reverzibilne inhibicije, kao i adekvatna razrjeđenja u Ellmanovoj metodi potrebna za zaustavljanje ovih reakcija. Stoga je cilj ovog projekta detaljno istražiti mehanizme interakcija BChE i moguća ograničenja, koristeći cjelovitu analizu dosadašnjih spoznaja te istraživanjem interakcija BChE s poznatim i novim spojevima. Biokemijski mehanizam enzimskih interakcija proučavat će se na molekulskom nivou pomoću in silico, in vitro i ex vivo metoda. Kinetičke konstante ispitivanih reakcija odredit će se na temelju poznatih kinetičkih modela, dok će u slučaju ne standardne regresijse biti razvijeni novi kinetički modeli. Ove složene analize dat će uvid u strukturna svojstva koje neki spoj mora zadovoljiti kako bi ostvario produktivne interakcije s BChE čime će se stvoriti osnove za dizajn i sintezu reaktivatora fosfilirane BChE kao i potencijalnih lijekova za bolesti koje uključuju inhibiciju BChE. Stoga, rezultati ovog projekta će otvoriti nove perspektive, a njihov će utjecaj izaći iz okvira istraživanja kolinesteraza.]]></summary_hr><summary_en><![CDATA[The inhibition of butyrylcholinesterase (BChE) in human tissues by binding of compounds to its active site serine is important for the detoxification and scavenging of xenobiotics such as organophosphates (OP) as well as for the metabolism of pro-drugs and drugs such as the carbamate bambuterol and the phenothiazine ethopropazine. Despite of the importance of BChE, its kinetic reactions were investigated mostly as comparative studies on the related enzyme acetylcholinesterase (AChE), which has a vital function in cholinergic neurotransmission. Moreover, reactivators of inhibited BChE, as well as drugs for the treatment of neurodegenerative diseases were empirically synthesized before the BChE crystal structure was resolved. Due to specific structural requirements, its binding affinity, inhibition and reactivation rates have not been rigorously investigated. It is known from our recent analyses that reactivation rates are influenced by experimental design and assays need to account for side reactions – oximolysis, reversible inhibition, and adequate dilution of reactants. Therefore, this project utilizes known and new compounds to gain a better understanding of the mechanistic basis of cholinesterase family interactions and their limitations. The biochemical mechanism of enzyme interactions will be comprehensively studied on a molecular level with in silico, in vitro, and ex vivo methods. Kinetic constants of the studied interactions will be determined based on known kinetic models, while in need of unusual regression analysis new kinetic models will be developed. These comprehensive analyses will explain structural requirements for compounds interacting with BChE and gain a platform for synthesis of reactivators of inhibited BChE and potentially active drugs in disorders that involve BChE inhibition. Many of the findings that should arise from this project will impact the mechanisms of hydrolytic catalysis, extending beyond the field of cholinesterases.]]></summary_en></project><project>
<id>8053</id><title_hr><![CDATA[Uspostava integralnog sustava za upravljanje službenom dokumentacijom Republike Hrvatske]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6211</user_id><user_firstLast_name>Jan Šnajder</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-2399</code><acronim><![CDATA[]]></acronim><duration>01.03.2019 - 28.02.2023</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>25726</team_members_id><team_members_names><![CDATA[ Doktorand: Zoran Medić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>8056</id><title_hr><![CDATA[Filogeografija i evolucija triju ekološki divergentnih grupa amfi-jadranskih biljaka]]></title_hr><title_en><![CDATA[]]></title_en><user_id>13550</user_id><user_firstLast_name>Ivana Rešetnik</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-3036</code><acronim><![CDATA[AmphiAdriPlant]]></acronim><duration>17.09.2019 - 31.08.2023</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>28771</team_members_id><team_members_names><![CDATA[ Doktorand: Marko Doboš Doboš ]]></team_members_names><keywords_hr><![CDATA[filogeografija, glacijalni refugiji, amfi-jadranske biljke, modeliranje ekoloških niša, RADseq]]></keywords_hr><keywords_en><![CDATA[phylogeography, glacial refugia, amphi-Adriatic plants, habitat suitability models, RADseq]]></keywords_en><summary_hr><![CDATA[Jugoistočna Europa predstavlja jedan od glavnih centara europske bioraznolikosti, prvenstveno zahvaljujući činjenici da su Apeninski i Balkanski poluotok djelovali kao glavni glacijalni refugiji biljnih i životinjskih vrsta tijekom glacijalno-interglacijskih ciklusa u Kvartaru. U sklopu ovog projekta predlažemo komparativnu filogeografsku studiju koja kombinira tradicionalne (morfolgija i plastidne DNK sekvence) i nove pristupe, kao što su sekvenciranje slijedeće generacije (RADseq) i modeli povoljnosti staništa kako bi se istražiti evolucijski putevi i diversifikacija triju ekološki divergentnih biljnih skupina rasprostranjenih na Apeninskom i Balkanskom poluotoku. Prvo ćemo rekonstruirati pojedinačne filogeografije vrsta Aurinia leucadea, A. sinuata, Festuca bosniaca i Dianthus sylvestris grupe na Balkanu i Apeninima kako bismo otkrili detaljne obrasce genetske raznolikosti divergentnih linija. Drugo, identificirat ćemo morfološke varijacije u istraživanim skupinama i ispitati da li morfološka divergencija odgovara genetskoj raznolikosti i/ili trenutnoj taksonomiji. Treće, procijenit ćemo njihove ekološke niše kako bismo otkrili potencijalnu sadašnju i prošlu rasprostranjenost te ćemo istražiti odnose između genetskih i ekoloških razlika. Četvrto, ispitat ćemo prostornu i vremensku podudarnost između rekonstruiranih filogeografija i usporediti dobivene lokacije glacijalnih refugija kao i putanje postglacijalnih širenja. Važnost predloženog projekta leži u tri točke: 1) dobiveni RADseq podaci visoke razlučivosti omogućit će sveobuhvatno ispitivanje prirodnih varijacija u širokom prirodnom okruženju, 2) dobiveni rezultati predstavljat će izravan doprinos očuvanju i upravljanju prirodom, i 3) sinteza komparativne filogeografije i modeliranja povoljnosti staništa pridonijet će rješavanju intrigantnih pitanja koja su daleko izvan ispitivane skupine: kako je bioraznolikost na Balkanu i Apeninima nastala te koji su procesi bili uključeni u njezino stvaranje. ]]></summary_hr><summary_en><![CDATA[South-eastern Europe is one of the major European biodiversity hotspots largely due to the fact that Apennine and Balkan Peninsulas have acted as major glacial refugia of temperate species during the Quaternary glacial–interglacial cycles. Here we propose a comparative phylogeographic study that combines traditional (morphology and plastid DNA sequences) and brand new approaches taking advantage of next-generation sequencing (RADseq) and habitat suitability modelling in order to explore the evolutionary trajectories and diversification of three ecologically divergent plant groups distributed on Apennine and Balkan Peninsulas. First, we will reconstruct the individual phylogeographic histories of Aurinia leucadea, A. sinuata, Dianthus sylvestris group and Festuca bosniaca on Balkan and Apennine Peninsulas to reveal range-wide patterns of genetic diversity. Second, we will identify morphological variation in the study groups and examine if morphological divergence corresponds to genetic diversity and/or current taxonomy. Third, we will evaluate their ecological niches to obtain potential present and past distributions and to examine the relationship between genetic and environmental divergence. Fourth, we will examine spatial and temporal congruence among the reconstructed phylogeographies and compare inferred locations of glacial refugia and postglacial expansion routes. The power of the proposed study lies in three points: 1) the implementation of high-resolution RADseq data will provide comprehensive examination of natural variation within range-wide native environment, 2) the obtained results will present direct contribution to nature conservation and management, and 3) the synthesis of comparative phylogeography and habitat suitability modelling will yield a much broader basis to address questions of interest going far beyond the group investigated: how the biodiversity on the Balkans and Apennines arose and which processes were involved in its formation. ]]></summary_en></project><project>
<id>8058</id><title_hr><![CDATA[Agrivi Smart - povećanje produktivnosti uzgoja krumpira uz pomoć algoritama strojnog učenja]]></title_hr><title_en><![CDATA[]]></title_en><user_id>13406</user_id><user_firstLast_name>Zvonko Kostanjčar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-7845</code><acronim><![CDATA[]]></acronim><duration>07.03.2019 - 07.10.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>25649</team_members_id><team_members_names><![CDATA[ Doktorand: Fredi Šarić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>8059</id><title_hr><![CDATA[Koncept nepomičnog pola u numeričkom modeliranju Cosseratovog kontinuuma]]></title_hr><title_en><![CDATA[]]></title_en><user_id>527</user_id><user_firstLast_name>Gordan Jelenić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-8806</code><acronim><![CDATA[FIMCOS]]></acronim><duration>15.03.2019 - 15.08.2023</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Temeljne tehničke znanosti, </scie_field_hr><scie_field_en>Basic engineering sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Građevinski fakultet u Rijeci]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Civil Engineering]]></institution_en><team_members_id>27510</team_members_id><team_members_names><![CDATA[ Doktorand: Laura Žiković ]]></team_members_names><keywords_hr><![CDATA[Cosseratov kontinuum, opis metodom nepomičnoga pola, metoda konačnih elemenata, objektivnost, konzervativna integracija, identifikacija parametara]]></keywords_hr><keywords_en><![CDATA[Cosserats&#39; continuum, fixed-pole description, finite-element method, objectivity, conservative integration, parameter identification]]></keywords_en><summary_hr><![CDATA[U ovome projektnom prijedlogu razmatra se alternativna teorija kontinuuma poznata pod nazivom Cosseratova ili mikropolarna teorija. Predlaže se provedba detaljnije analize u okviru  takozvane metode nepomičnog pola s ciljem razvoja točnih i djelotvornih konačnih elemenata za linearnu i nelinearnu statičku i dinamičku analizu.Elementi će biti razvijeni slijedom niza istraživačkih ciljeva koji se sastoje od (O1) linearne statičke analize, (O2) nelinearne statičke analize, (O3) dinamičke analize i (O4) identifikacije parametara. Na taj način, putem ciljeva O1-O3 razvijeni elementi će tvoriti simulacijski alat sami za sebe, dok će putem cilja O4 stvoriti neophodni preduvjet za robusnu i pouzdanu proceduru potrebnu za identifikaciju materijalnih parametara iz eksperimentalnih mjerenja. Konačni elementi će biti provjereni putem niza standardnih testnih primjera, a par eksperimentalnih postava bit će projektiran da zaključi cilj O4. Ciljevi će biti dosegnuti kroz niz istraživačkih, edukacijskih i upravljačkih aktivnosti koje će voditi članovi projektne grupe i koji će se bazirati na ranijim dostignućima grupe u razvoju konačnih elemenata uključujući vezanu interpolaciju, objektivnu interpolaciju ovisnu o konfiguraciji, algoritme za vremensku integraciju, Cosseratovu elastičnost, metodu nepomičnog pola u nelinearnim gredama i iskustvo u provedbi beskontanog mjerenja. Konačni elementi će biti razvijeni unutar programa za analizu metodom konačnih elemenata FEAP.S projektnim rezultatima upoznat ćemo eksperte i širu javnost putem raznih diseminacijskih kanala, uključujući objave u znanstvenim časopisima najviše kategorije u području računske mehanike, predstavljanja na uglednim specijaliziranim konferencijama, kao i predavanja s ciljem populariziranja projektnoga istraživanja i znanosti općenito.]]></summary_hr><summary_en><![CDATA[An alternative continuum theory called Cosserats’ or micropolar theory is considered within this proposal and a case is made for its more thorough analysis within the framework of the so-called fixed-pole description with the aim of providing accurate and efficient finite elements for linear and non-linear static and dynamic analysis. The elements will be developed by pursuing a set of research objectives consisting of (O1) linear static analysis, (O2) non-linear static analysis, (O3) dynamic analysis and (O4) parameter identification. In this way, through objectives O1-O3 the elements developed will be usable as a simulation tool in their own right while in O4 they will make a vital pre-requisite for a robust and reliable procedure needed for identification of material parameters from experimental measurements. The finite elements will be tested against a number of bench-mark problems, while a couple of experimental setups will be designed to complete O4.The objectives will be reached through a series of research, training and management activities led by the members of the project team and built on previous achievements of the team in finite-element design involving linked interpolation, objective configuration-dependent interpolation, time-stepping algorithms, conventional Cosserats&#39; elasticity, fixed-pole approach in geometrically exact beams as well as experience in performing contactless measurements. The finite elements will be developed within the finite-element-analysis programme FEAP.The project results will be communicated to the professionals and general public through a variety of dissemination channels involving publications in the scientific journals of the highest rank within the area of computational mechanics, presentations at highly reputable thematic conferences, and lectures aimed at popularising the project research and science in general.]]></summary_en></project><project>
<id>8060</id><title_hr><![CDATA[Strukturiran ekološki uzgoj primjenom autonomnih robota u staklenicima]]></title_hr><title_en><![CDATA[]]></title_en><user_id>21420</user_id><user_firstLast_name>Matko Orsag</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-1126</code><acronim><![CDATA[SPECULARIA]]></acronim><duration>15.03.2019 - 14.12.2021</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>24179</team_members_id><team_members_names><![CDATA[ Doktorand: Marsela Polić ]]></team_members_names><keywords_hr><![CDATA[Robotski sustavi, Bespilotne letjelice, Mobilna robotika, Podatni sustavi, Nelinearno upravljanje, Planiranje putanje, Planiranje zadataka ]]></keywords_hr><keywords_en><![CDATA[Robotic systems, Unmanned aerial vehicles, Mobile robotics, Compliant systems, Nonlinear control, Path planning, Path planning ]]></keywords_en><summary_hr><![CDATA[Cilj ovog projektnog prijedloga jest uspostaviti istraživačku grupu pri Fakultetu elektrotehnike i računarstva Sveučilišta u Zagrebu s istraživačkim fokusom na dvije posebno aktualne grane robotskog istraživanja, podatne manipulacije i heterogenih robotskih sustava. Predložene teme su trenutno jedne od najvećih pokretača istraživanja u robotici, te su pronašle svoju primjenu u različitim granama, počevši od medicine i industrije, pa sve do svemirske robotike. Budući da su ambiciozni praktični problemi, često najbolji pokretači istraživanja, za testiranje predloženih algoritama i ispitivanje sustava predložen je interdisciplinarni scenarij primjene heterogenog robotskog sustava u staklenicima organske poljoprivrede. Predloženim projektom planira se zaposliti i usavršiti doktorand i poslijedoktorand, odnosno educirati više generacija studenata fakulteta kroz rad na projektu. Uspješan nastavak rada na predloženoj temi, predviđen je, uz potporu Inovacijskog Centra Nikola Tesla, razvojem grupe u dva smjera: temeljno istraživanje i industrijsko primjenjivo istraživanje. Interdisciplinarnost projekta očituje se kroz horizontalnu temu poljoprivrede, a osigurana je potporom tvrtke Agrivi koja će pružiti svoje znanje i iskustvo.]]></summary_hr><summary_en><![CDATA[The main goal of this proposal is to establish a research group capable of performing internationally relevant research in the field of compliant robot control and heterogeneous robotic system in general, within the University of Zagreb Faculty of Electrical Engineering and Computing. These emerging topics are one of the most powerful drivers of robotic research. They are applied to various fields of research, including medical, industrial and even space robotics. Because, often enough practical problems are the best drivers of research, the project proposes validating these robotics research topics, in a scenario involving a heterogeneous robotics system utilized to help farmers in indoor organic agriculture. Project aim to employ and educate a PhD student and a Postdoctoral researcher, as well as offer undergraduate students an opportunity to work and learn on cutting edge robotics problems. Proposed three stage development of the group, in both basic technology research and industrial application, through the help of Innovation Center Nikola Tesla, will make sure the group continues the develop after the proposed project has ended. Interdisciplinary characteristic of the proposal is manifested through the application to agriculture and supported by a Croatian ICT company Agrivi, specialized in agriculture.]]></summary_en></project><project>
<id>8061</id><title_hr><![CDATA[Mikrostrukture jugoslavenskoga socijalizma: Hrvatska 1970-1990.]]></title_hr><title_en><![CDATA[]]></title_en><user_id>2955</user_id><user_firstLast_name>Igor Duda</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-5967</code><acronim><![CDATA[MICROSOCIALISM]]></acronim><duration>01.04.2019 - 01.07.2023</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Povijest, </scie_field_hr><scie_field_en>History, </scie_field_en><institution_hr><![CDATA[Sveučilište Jurja Dobrile u Puli]]></institution_hr><institution_en><![CDATA[Juraj Dobrila University of Pula]]></institution_en><team_members_id>23306</team_members_id><team_members_names><![CDATA[ Doktorand: Tina Filipović ]]></team_members_names><keywords_hr><![CDATA[samoupravni socijalizam, društvene strukture, mikrohistorija, Hrvatska, povijest Jugoslavije]]></keywords_hr><keywords_en><![CDATA[self-managed socialism, social structure, microhistory, Croatia, history of Yugoslavia]]></keywords_en><summary_hr><![CDATA[Sedamdesete i osamdesete godine vrijeme su u potpunosti oblikovanoga jugoslavenskog socijalističkog sustava u kojem je samoupravljanje primijenjeno na svim razinama s namjerom odumiranja države i prepuštanja njezinih ovlasti samoupravnim zajednicama i organizacijama. Općina je bila zamišljena kao zajednica u kojoj se na mikrorazini aktiviraju sve poluge društveno-političkog ustroja. Osnovni znanstveni cilj projekta je istraživanjem društvenih odnosa i struktura u odabranim općinama dati odgovore na pitanja o funkcioniranju kasnoga socijalizma. Pozornost će biti usmjerena na ulogu građana kao samoupravljača u mjesnim zajednicama, zaštitu samoupravnih prava i društvenoga vlasništva, javnu i državnu sigurnost, lokalne medije koji stvaraju sliku o zajednici, položaj organizacija udruženog rada između ekonomije i politike, kulturno stvaralaštvo i kulturnu politiku u samoupravnim interesnim zajednicama, ulogu žene i ženskoga aktivizma te na položaj i utjecaj boraca i njihove veteranske organizacije. Poredbena analiza studija slučaja daje uvid u splet međuodnosa koji svjedoče o položaju moći, društvenoj umreženosti, stanju zajamčenih prava i sloboda, nadzoru i udovoljavanju različitim interesima. Metodološki pristup proizlazi iz perspektive društvene, kulturne, političke i ekonomske povijesti, povijesti svakodnevice i mentaliteta te povezivanja pogleda odozdo i odozgo, horizontalne i vertikalne komunikacije, odnosno mikropovijesti s makropovijesnim okvirom. Rezultati će biti objavljeni kao znanstvena monografija, zbornik radova i još dvadesetak izvornih znanstvenih radova.]]></summary_hr><summary_en><![CDATA[The 1970s and 1980s were a time in which the Yugoslav socialist system was fully formed, and during which self-management was implemented at all levels, in order for the state to wither away and to leave its powers to self-managed communities and organizations. The municipality was envisioned as a small community in which all the levels of the general socio-political organization were established, only on a microscale. The main academic aim of the project is to unravel the functioning of late socialism through an investigation of social relations and structures in selected municipalities. The project will focus on the role of citizens as self-managers in local communities, on the protection of self-management rights and social property, on public and state security, on local media in charge of creating an image of the community, on the position of organizations of associated labour between economics and politics, on cultural creativity and cultural politics in self-managed communities of interests, on the role of women and women&#39;s activism, and on the position and influence of veterans and their organization. A comparative analysis of case studies will shed light on the interplay of relationships that provide insights into issues such as power relations, social networking, the status of guaranteed rights and freedoms, as well as surveillance and compliance with different interests. The methodological approach will rely on social, cultural, political and economic history, the history of everyday life and the history of mentality. It will also establish connections between perspectives from below and perspective from above, as well as between horizontal and vertical communication, connecting microhistory with a macro-historical framework. The research results will be presented through an academic monograph, an edited volume and another twenty academic papers based on original research.]]></summary_en></project><project>
<id>8063</id><title_hr><![CDATA[Biokemijski odgovori površinskog sloja oligotrofnog područja Jadranskog mora na atmosfersko taloženje]]></title_hr><title_en><![CDATA[]]></title_en><user_id>84</user_id><user_firstLast_name>Sanja Frka Milosavljević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-2664</code><acronim><![CDATA[BiREADI]]></acronim><duration>08.03.2019 - 07.10.2023</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Interdisciplinarne prirodne znanosti, </scie_field_hr><scie_field_en>Interdisciplinary natural sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>25777</team_members_id><team_members_names><![CDATA[ Doktorand: Andrea Milinković ]]></team_members_names><keywords_hr><![CDATA[atmosfersko taloženje, površinski (mikro)sloj mora, Jadransko more, fitoplankton, hranjive soli, organska zagađivala, tragovi metala, površinski film]]></keywords_hr><keywords_en><![CDATA[atmospheric deposition, sea surface (micro)layer, Adriatic Sea, phytoplankton, macronutrients, organic pollutants, trace metals, surface films]]></keywords_en><summary_hr><![CDATA[Najizazovnija područja istraživanja globalnih klimatskih promjena danas uključuju kompleksna međudjelovanja biologije i kemije površinskih voda, atmosferske kemije te klime koja bi mogla imati još veći značaj u budućim klimatskim scenarijima. Koristeći multidisciplinarni, cjeloviti pristup, BiREADI ima za cilj ispitati utjecaje atmosferskog taloženja (AT) na složene biokemijske odgovore oligotrofnih vodenih sustava; primarno fitoplanktonskih zajednica te, posljedično, i na kemijske promjene u površinskim slojevima, uključujući mikrosloj na granici faza zrak-voda. Predložen je fazni pristup i specifični ciljevi: (I) procijeniti koncentracije, izvore i taložne tokove atmosferskih sastavnica te prirodu obogaćenja površinskih slojeva mora hranjivim solima, tragovima metala i organskim zagađivalima, (II) procijeniti utjecaje okolišnog AT na fiziologiju i biomasu prirodne planktonske populacije, a time i na kemiju površinskih slojeva mora, (III) dobiti uvid u mehanizme kojima AT utječe na morski fitoplankton, ali i procijeniti toksične učinke sinergijskog djelovanja atmosferskih zagađivala na različite razine biološke organizacije vodenih sustava, (IV) bolje razumijevanje prirode varijabilnosti biogene organske tvari  vodenih površinskih slojeva pod utjecajem AT te mehanizama stvaranja površinskih filmova i njihovih svojstava. BiREADI će značajno doprinijeti temeljnom razumijevanju povezanosti procesa AT i biokemijskih odgovora morskih površinskih sustava primjenom najsuvremenijih laboratorijskih ispitivanja, modeliranja, složenog terenskog rada, uključujući i mezokozmos na području srednjeg Jadrana–oligotrofnoj zoni i ključnom području proučavanja biokemijskih učinaka AT na Jadransko more.]]></summary_hr><summary_en><![CDATA[Complex interactions between surface water chemistry, phytoplankton, atmospheric chemistry, and climate are among the most challenging global climate issues today, and should become even more pronounced in future climate scenarios. With a holistic, multidisciplinary approach, the BiREADI is designed to assess the impact of atmospheric deposition (AD) on complex biochemical responses of oligotrophic systems, considering the importance of promotion and inhibition effects on phytoplankton, and the consequent altering of the surface water chemistry, including the sea surface microlayer at the air-water interface. To achieve the main project goals, a phased approach is proposed: Phase I - to evaluate concentrations, sources and deposition fluxes of atmospheric constituents, and to get insight into the nature of enrichments of macro-nutrients, trace metals and organic pollutants within the sea surface layers; Phase II - to assess the impact of ambient AD from diverse sources on the physiology and biomass of the natural plankton population, and consequently on the chemistry of the sea surface layers; Phase III - to get insight into the mechanisms by which AD affects marine phytoplankton, but also to assess the toxic effects of atmospheric pollutants that can interact synergistically on various levels of biological organisation in aquatic systems; Phase IV - to better understand the nature of biogenic OM variabilities within the aqueous surface layers affected by AD inputs with the consequences on the surface film formation and properties. The BiREADI will make a significant progress in the fundamental understanding of the linkage between AD inputs and complex surface ocean biochemical responses by a state-of-the-art laboratory and modelling studies, and by comprehensive field work including the mesocosm experiment at the Middle Adriatic - an extremely oligotrophic water zone and the «hotspot» area to study the biochemical effects of AD to the Adriatic Sea.]]></summary_en></project><project>
<id>8064</id><title_hr><![CDATA[Sinteza supramolekulskih samo-udruženih nanostruktura za izgradnju naprednih funkcionalnih materijala]]></title_hr><title_en><![CDATA[]]></title_en><user_id>348</user_id><user_firstLast_name>Leo Frkanec</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-8355</code><acronim><![CDATA[SUPeRNANO]]></acronim><duration>13.05.2019 - 12.02.2026</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>28075</team_members_id><team_members_names><![CDATA[ Doktorand: Nika Gazdek ]]></team_members_names><keywords_hr><![CDATA[supramolekulska kemija,  sinteza, samo-udruge, nanostrukture, napredni funkcionalni materijala]]></keywords_hr><keywords_en><![CDATA[Supramolecular Chemistry, Synthesis, Self-assembles, Nanostructures, Advanced Functional Materials]]></keywords_en><summary_hr><![CDATA[Istraživanja u okviru predloženog projekta su interdisciplinarna s ciljem dizajna, supramolekulske  sinteze i karakterizacije novih samoorganizirajućih nano-struktura za izgradnju naprednih funkcionalnih materijala. Molekularno samoudruživanje koristi prednosti supramolekulskih interakcija (ionske, hidrofobne, van der Waals-ove, vodikove i koordinacijske veze)  koje omogućavaju konstruiranje novih nanostruktura  atraktivnih svojstava. Temeljeno na zakonitostima supramolekulske kemije, „bottom-up“ pristup za projektiranje funkcionalnih struktura u nano dimenzijama omogućuje nastajanje vrlo sofisticiranih materijala za široku primjenu. Takve strukturne karakteristike danas su dobro poznate i mogu se precizno kontrolirati kako bi se uvela i prilagodila specifična funkcionalna svojstva samoorganiziranih nanomaterijala. Nadalje, ovi sustavi pokazuju složenu morfologiju i dinamiku te imaju veliki potencijal za primjenu u biomedicinskim znanostima, informacijskim tehnologijama i znanostima o okolišu. U nastavku naših istraživanja supramolekulskih sustava pažnja u ovom projektu bit će usmjerena na dva glavna područja: 1) nanoproizvode, sintezu i karakterizacija novih mekih nanomaterijala temeljenih na organo- i hidro-gelovima s inkorporiranim oksalilamidnim ili fumaramidnim centralnim jedinicama i sinteze bioinspiriranih supramolekulskih sustava baziranih na samoorganizacijama  prirodnih peptida, priprava novih materijala polimerizacijom gelske mreže i razvoj novih supramolekulskih materijala koje uključuju fotoaktivne funkcionalne skupine 2) dizajn, priprema i karakterizacija novih funkcionalnih supramolekulskih sustava baziranih na liposomima i ß-ciklodekstrinama za ciljanu dostavu lijekova i istraživanje staničnog prepoznavanja. Nadalje, testirat će se biološki potencijal sintetiziranih funkcionalnih supramolekulskih sustava u dostavi lijekova i genskoj dostavi.]]></summary_hr><summary_en><![CDATA[Research in the framework of the proposed project is interdisciplinary with the aim of design, supramolecular synthesis and characterization of new functional supramolecular self-assembled nanostructures for construction of advanced functional materials. Molecular self-assembly usually takes advantage of supramolecular interactions (ionic, hydrophobic, van der Waals, hydrogen and coordination bonds) which allow construction of new nanostructures with attractive properties. Based on the rules of supramolecular chemistry, the bottom-up approach to design functional structures at the nanoscale is currently producing highly sophisticated materials for wide application. These structural features are nowadays well understood and can be finely controlled in order to introduce and tune specific functional properties of self-assembled nanomaterials. Further, such systems exhibit a complex array of morphologies and dynamics and have a huge potential for new applications in biomedical sciences, information technologies and environmental sciences. In continuation of our previous research of self-assembly systems the attention in this project will be focused on two main areas of research: 1) nanofabrication, preparation and characterization of new soft nanomaterials based on organo- and hydro-gels with incorporated oxalylamide or fumaramide central units and synthesis of bioinspirated supramolecular systems based on self-assembled natural peptides, the preparation of new materials by gel polymerization and the development of new supramolecular materials that incorporate photoactive functional groups 2) design, preparation and characterization of new functional supramolecular systems based on liposomes and ß-cyclodextrines for targeted drug delivery and surface recognition studies. Further, biological potential of synthesized functional supramolecular systems in drug and gene delivery will be tested. ]]></summary_en></project><project>
<id>8065</id><title_hr><![CDATA[Napredni nositelji energije u oporabi plastičnog otpada (NEOPLAST)]]></title_hr><title_en><![CDATA[]]></title_en><user_id>2536</user_id><user_firstLast_name>Daniel Rolph Schneider</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-6944</code><acronim><![CDATA[]]></acronim><duration>15.03.2019 - 15.11.2023</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, </scie_field_hr><scie_field_en>Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>25819</team_members_id><team_members_names><![CDATA[ Doktorand: Irma  Kremer ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>8066</id><title_hr><![CDATA[Kolektivna dinamika u magnetoelektricima]]></title_hr><title_en><![CDATA[]]></title_en><user_id>12365</user_id><user_firstLast_name>Damir Dominko</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-4483</code><acronim><![CDATA[ColDynaMo]]></acronim><duration>01.10.2019 - 31.03.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut za fiziku]]></institution_hr><institution_en><![CDATA[Institute of Physics in Zagreb]]></institution_en><team_members_id>28904</team_members_id><team_members_names><![CDATA[ Doktorand: Virna Kisiček ]]></team_members_names><keywords_hr><![CDATA[multiferoik,magnetoelektrik,dielektrik,susceptibilnost,infracrveno,spektroskopija]]></keywords_hr><keywords_en><![CDATA[multiferroic,magnetoelectric,dielectric,susceptibility,infrared,spectroscopy]]></keywords_en><summary_hr><![CDATA[Multiferoični i magnetoelektrični sustavi su novi materijali u fizici čvrstog stanja s izravnom primjenom u industriji visoke tehnologije. Tome svjedoči rastući broj publikacija svake godine u časopisima s visokim faktorom utjecaja. Koristeći zajedno naše kompetitivne i komplementarne eksperimentalne tehnike na Institutu za fiziku u jedinstvenom smo položaju da istražimo ovu široku klasu uzbudljivih materijala. Naš predloženi projekt u skladu je s dva infrastrukturna projekta na Institutu za fiziku: Kriogeni centar Instituta za fiziku - KaCIF i Centar za napredne laserske tehnike - CALT. Sinergija ovog projektnog prijedloga s novim mogućnostima KaCIF-a i CALT-a će dati i nova fundamentalna saznanja o magnetoelektričnom vezanju odgovornom za egzotičnu multiferoičnost. Očekujemo visoki broj publikacija u vrhunskim časopisima iz područja. Ovaj prijedlog je također i platforma za doktorande i poslijedoktorande koji će nam se pridružiti u istraživanju da razviju svoju karijeru. Također planiramo proširiti naše istraživanje slanjem novih projektnih prijedloga na kompetitivne natječaje drugih izvora financiranja.Posebno, namjeravamo istražiti tri grupe multiferoičnih materijala: frustrirane nesumjerljive antiferomagnete, višedomenske magnete s električnom polarizacijom te heksaferite s kemijskom kontrolom svojstava. Cilj je sistematski opisati njihova kolektivna pobiuđenja u sektoru naboja i spina koristeći THz zračenje, magnetska, transportna i dielektrična mjerenja.]]></summary_hr><summary_en><![CDATA[Multiferroics and magnetoelectric systems are novel materials in solid state science with direct application in the high-tech industry. This is evidenced by the growing number of publications in high-impact-factor journals each year. Combining our competitive and complementary experimental techniques at Institute of Physics, we are uniquely positioned to research this broad and exciting class of materials. Our proposed project is in line with two infrastructural projects at our Institute: Cryogenic Centre at the Institute of Physics - KaCIF and Centre for Advanced Laser Techniques - CALT. The synergy of this project proposal with the new possibilities within KaCIF and CALT will result in new fundamental understanding about magnetoelectric coupling ruling a selection of exotic new multiferroics. We expect high publicability in top journals in the field. This proposal is also a platform for doctoral and postdoc students joining us in research to develop their careers. We also plan to extend our research by submitting new proposals to competitive funding calls of other funding agencies.Specifically, we plan to research three groups of multiferroic materials: frustrated incommensurate antiferromagnets, multi-domain magnets with electric polarization as well as chemically-controlled hexaferrites. The aim is to systematically describe their collective excitations in the spin and charge sector using THz radiation, magnetic, transport and dielectric bulk techniques.]]></summary_en></project><project>
<id>8067</id><title_hr><![CDATA[Geoprostorno praćenje zelene infrastrukture na temelju terestričkih, zračnih i satelitskih snimaka]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3478</user_id><user_firstLast_name>Mario Miler</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-8609</code><acronim><![CDATA[GEMINI]]></acronim><duration>01.05.2019 - 01.05.2023</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Geodezija, </scie_field_hr><scie_field_en>Geodesy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Geodetski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Geodesy]]></institution_en><team_members_id>26389</team_members_id><team_members_names><![CDATA[ Doktorand: Petar Božičević ]]></team_members_names><keywords_hr><![CDATA[geoinformatika, zelena infrastruktura, fotogrametrija, daljinska istraživanja, geostatistika]]></keywords_hr><keywords_en><![CDATA[geoinformatics, green infrastructure, photogrammetry, remote sensing, geostatistics]]></keywords_en><summary_hr><![CDATA[Zelena infrastruktura je mreža prirodnih i izgrađenih područja, objekata i zelenih površina u ruralnom i urbanom prostoru koja omogućuje društvu održivo zdravo okružje za svakodnevni život. Satelitska daljinska istraživanja predstavljaju ključni izvor podataka za kartiranje takvih okružja, ali nisu dovoljna za njihovo potpuno razumijevanje, jer zelena infrastruktura također sadrži i vertikalne strukture kao što su zelene terase i balkoni koje nije moguće snimiti vertikalnim satelitskim opažanjima. Nijedan pojedinačni izvor podataka nije dovoljan kako bi se kvalitetno kartiralo, pratilo, modeliralo i na kraju razumjelo i upravljalo interakcijom s takvim urbanim sustavima. Beskontaktno snimanje uz pomoć bespilotnih letjelica značajno proširuje mogućnosti prikupljanja dodatnih informacija potrebnih za praćenje zelene infrastrukture unutar urbanih područja na brz i jednostavan način. Glavni cilj ovog istraživačkog projekta je u ispitivanju i uspostavi inovativnog, više­dimenzionalnog sustava praćenja urbane zelene infrastrukture, koji integrira najnovije mogućnosti pridobivanja statičkih i dinamičkih multispektralnih informacija (satelitske snimke, zračne i terestričke snimke), naprednih prostornih analiza sa svrhom unapređenja sustava upravljanja i odlučivanja o zelenim gradskim područjima. S obzirom na trenutno stanje i značaj istraživane problematike, očekivani rezultati projekta omogućit će značajno tehnološko i metodološko unapređenje sadašnjih sustava upravljanja ZI u Hrvatskoj i Europi. Područje istraživanja obuhvaća urbano područje grada Zagreba s naglaskom na zaštićena zelena područja. Istraživanje se temelji na geoprostornim tehnologijama i metodama: daljinska istraživanja i geoinformacijski sustavi omogućit će integraciju utemeljenu na standardima Otvorenog geoprostornog konzorcija. Klasifikacija, određivanje granica objekata i ostale metode daljinskih istraživanja bit će temeljene na terestričkim, zračnim i satelitskim multispektralnim snimkama.]]></summary_hr><summary_en><![CDATA[Green infrastructure (GI) is a network of natural and semi-natural areas, features and green spaces in rural and urban areas that collectively provide society sustainable healthy living environment. Satellite remote sensing technology provides a key data source for mapping such environments, but is not sufficient for fully understanding them, because GI also comprise vertical structures like green terraces and balconies that are not detectable by perpendicular satellite imagery. No single data source is sufficient to satisfy the information needs required to map, monitor, model, and ultimately understand and manage our interaction within such urban systems. Unmanned Aerial Vehicles (UAV) based remote sensing offers great possibilities to acquire field data for monitoring of GI within the urban areas in a fast and easy way. The main objective of this research project is to establish an innovative, multidimensional system for monitoring of urban green infrastructure, which integrates the latest means of data collection (multispectral satellite imagery improved and calibrated with high resolution terrestrial and airborne multispectral sources), advanced spatial analysis with the aim to improve decision support system for better management of urban GI. Taking in the account current state of the art and the importance of research topic, the results of the project will significantly improve the technology and methodology of current management techniques of GI in Croatia as well as Europe.The proposed study area is the urban area of the city of Zagreb with focus on protected green areas inside the city. The research will be based on geospatial technologies and techniques: Remote Sensing and GIS tools and recommend a holistic integration of these technologies within the language of Open Geospatial Consortium (OGC) standards. Classification, object detection and other remote sensing methods will be based on the terrestrial, airborne and satellite multispectral imagery.]]></summary_en></project><project>
<id>8068</id><title_hr><![CDATA[Patogeni potencijal Virusa uvijenosti lista vinove loze 3 i njegova interakcija s domaćinskim biljkama]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3236</user_id><user_firstLast_name>Katarina Hančević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-6049</code><acronim><![CDATA[GRAPE-PATH3]]></acronim><duration>01.04.2019 - 01.07.2023</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut za jadranske kulture i melioraciju krša]]></institution_hr><institution_en><![CDATA[Institute for Adriatic Crops and Karst Reclamation in Split]]></institution_en><team_members_id>26106</team_members_id><team_members_names><![CDATA[ Doktorand: Mate Čarija ]]></team_members_names><keywords_hr><![CDATA[vinova loza, GLRaV-3,biološko indeksiranje, molekularna karakterizacija, fiziološki biljni odgovor ]]></keywords_hr><keywords_en><![CDATA[grapevine, GLRaV-3, biological indexing, molecular characterization, physiological plant responses]]></keywords_en><summary_hr><![CDATA[Bolest uvijenost lista vinove loze (GLD) jedna je od najznačajnijih virusnih bolesti vinove  loze, a virus uvijenosti lista vinove loze 3 (GLRaV-3) jedan je od glavnih uzročnika te bolesti. Istraživanja vezana za GLRaV-3 uglavnom su usmjerena na proučavanje epidemiologije bolesti i razvoja pouzdanih metoda detekcije, dok je uloga različitih genetičkih varijanti GLRaV-3 u GLD etiologiji i odgovor biljke na prisutnost ovog virusa u velikoj mjeri nepoznat. Glavni cilj ovog projekta je dijagnosticirati i bolje razumjeti promjene koje visoko patogeni virus GLRaV-3 uzrokuje u osjetljivim domaćinskim biljkama in vivo. Napraviti će se pregled distribucije ekonomski štetnih virusa vinove loze u autohtonim kultivarima vinove loze južne Hrvatske s posebnim osvrtom na GLRaV-3 i njegove genetske varijante. Varijante čistih sojeva ovog virusa prisutne u jadranskim vinogradima, kao i njihove kombinacije molekularno će se okarakterizirani koristeći PCR i SSCP metode te će se biološki okarakterizirati na setu bezvirusnih indikatorskih biljaka. Koristit će se tri biološke indikatorske vrste koje intenzivno razvijaju simptome GLRaV infekcije i stoga su najbolji domaćini za otkrivanje morfoloških, fizioloških i biokemijskih promjena koje ovaj virus uzrokuje. Odgovori domaćina promatrat će se preko promjena u sastavu nutrienata, promjena hormonskog statusa, enzimskih aktivnosti uključenih u stresna stanja, fotosinteze i transpiracije, sadržaja klorofila, permeabilnosti membrane i sadržaja vode. Posebna pažnja posvetit će se interakciji virusa i odabranih domaćinskih biljaka kroz dinamiku virusne replikacije u biljkama domaćina tijekom procesa infekcije metodom real-time RT-PCR. Dobiveni rezultati omogućit će bolje razumijevanje patogenog potencijala čistih varijanti GLRaV-3 i njihovih kombinacija te posljedica koje ovaj virus ima na autohtone sorte vinove loze s jadranskog područja, osim već dobro proučenih vidljivih simptoma uvijenosti lista. ]]></summary_hr><summary_en><![CDATA[Grapevine leafroll disease (GLD) is one of the most important grapevine viral diseases, with the Grapevine leafroll-associated virus-3 (GLRaV-3) being one of its main causal agents. Research on GLRaV-3 has been largely focused on epidemiology and the development of reliable detection assays while the role of different genetic variants of GLRaV-3 in GLD aetiology and consequent plant response is largely unknown. The main objective of this study is to diagnose and better understand changes that highly pathogenic GLRaV-3 induce in susceptible hosts’ plant in vivo. Distribution screening in autochthonous grapevine cultivars of Southern Croatia will be performed with special attention to GLRaV-3 and its genetic variants. Pure variants present in Adriatic vineyards as well as their combinations molecularly determined by PCR and SSCP methods will be biologically characterised on the set of virus-free indicator plants. Three biological indicators of GLD are the most sensitive woody species that strongly develop symptoms of GLRaV-3 infection and thus are the best hosts to detect morphological, physiological and biochemical changes this virus causes. Host responses will be observed via changes in nutrient status, hormonal statuses, enzyme activity involved in scavenging stressed condition, photosynthetic and transpiration rates, chlorophyll content, membrane permeability and water content. Special attention will be paid on the interaction between virus and host plants by exploring the dynamic of virus replication throughout the infection processes examined by real-time RT-PCR. Obtained results will enable deeper understanding of the pathogenic potential of GLRaV-3 pure strains and their combinations and the consequences on the autochthonous grapevine cultivars from the Adriatic coast, apart from the well-studied visible symptoms. ]]></summary_en></project><project>
<id>8069</id><title_hr><![CDATA[Bolničke zaštitne tekstilije]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3088</user_id><user_firstLast_name>Anita Tarbuk</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-4254</code><acronim><![CDATA[HPROTEX]]></acronim><duration>25.04.2019 - 25.04.2023</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Tekstilna tehnologija, </scie_field_hr><scie_field_en>Textile technology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Tekstilno-tehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Textile Technology]]></institution_en><team_members_id>26302</team_members_id><team_members_names><![CDATA[ Doktorand: Ivana Čorak ]]></team_members_names><keywords_hr><![CDATA[generiranje tekstilne prašine, bolničke tekstilije, celulozne tkanine, kationiziranje, međupovršinske pojave, praćenje umrežavanja, postojane obrade]]></keywords_hr><keywords_en><![CDATA[textile dust generating, hospital textiles, cellulosic fabrics, cationization, interface phenomena, crosslinking monitoring,  durable  treatments]]></keywords_en><summary_hr><![CDATA[Glavni ciljevi projekta su uspostava interdisciplinarne istraživačke skupine, uključujući i mladog istraživača doktoranda, i Laboratorija za kontrolirano praćenje procesa umrežavanja, čime će se omogućiti sustavno istraživanje i prijenos znanja usmjerenih rješavanju problema pojave tekstilne prašine, potencijalnog prijenosnika zaraza i uzročnika kvarova uređaja u bolničkom okruženju. Proizvest će se tkanine od pređa iz pamuka (CO) i pamuk/poliestera (CO/PES) u svrhu istraživanja utjecaja konstrukcije pređe, veza i tkanine na generiranje tekstilne prašine prije i nakon provedenih ciklusa pranja. Razvijat će se i definirati uvjeti kationiziranja i antimikrobne dorade s kvarternim amonijevim spojevima, ß-ciklodekstrinima s inkapsuliranim antimikrobnim sredstvom i kitozanom u svrhu postizanja postojanosti na višestruke cikluse održavanja, a s ciljem minimalnog kemijskog i mehaničkog oštećenja što doprinosi manjem otpuštanju tekstilne prašine. Uspostavom Laboratorija detaljno će se istražiti sorpcija kupelji sa sredstvima za antimkrobnu obradu na tkanine primarno uzevši u obzir međupovršinska svojstva (DSA30S) i in situ praćenju utjecaja topline na fizikalno-kemijske promjene (FTIR-ATR GG) s ciljem preciznog definiranja sastava kupelji i procesnih parametra za postizanje postojanog umrežavanja. Promjene u CO i CO/PES tkaninama tijekom i nakon obrade, te višestrukih ciklusa održavanja, istražit će se na kristaliničnoj, fizikalno-kemijskoj i morfološkoj razini te analizom međupovršina primjenom FE-SEM, TGA, FTIR, XRD, MCC, GS-MS, EKA, SFE, CA, MMT, WRV, UV-VIS spektrofotometrijom. Novorazvijenim tkaninama ispitat će se toksičnost, te će se u skladu s dobivenim rezultatima predložiti njihova ciljana primjena u bolničkom okruženju uz prijedlog formulacije deterdženata i postupaka za njihovo održavanje. Pronalaženje i implementacija novih ideja bit će usmjerena prema poduzetništvu u svrhu poticanja gospodarskog rasta te daljnjim istraživanjima u okviru nove projektne prijave]]></summary_hr><summary_en><![CDATA[The project main goals are establishing of interdisciplinary research group, with young doctoral researcher, and Laboratory for Controlled Monitoring of the Crosslinking Process, enabling systematic research and knowledge transfer to solve the problem of generating textile dust, a disease carrier and instrument stoppage causer, in the hospital environment. The textile fabrics of cotton fibers (CO) and their polyester blends (CO/PES) will be produced. The influence of yarn, weave and fabric construction to the generating of textile dust before and after washing cycles will be researched. The conditions of cationization and antimicrobial finishing with quaternary ammonium compounds, ß-cyclodextrins with encapsulated antimicrobial agents, and chitosan will be developed to achieve permanency to textile care with minimizing chemical and mechanical damage, thereby contributing to a lower release of textile dust. By setting up a Laboratory, the fabric sorption of the bath with antimicrobial agents will be investigated through interfacial properties (DSA30S), and in situ heat-monitoring (FTIR-ATR GG) of physical-chemical change in fabric will be performed, in order to precisely define the bath composition and process parameters to achieve durable crosslinking. The change in CO and CO/PES during and after treatment, and after the textile care cycles, will be analyzed on crystalline, physico-chemical, morphological and interfacial level using FE-SEM, TGA, FTIR, XRD, MCC, GS-MS, EKA, SFE, CA, MMT, WRV, UV-VIS spectrophotometry. For the purpose of health and environment protection, all newly developed fabrics will be tested on toxicity and, according to the obtained results, their usage in the hospital environment with the proposal of detergent formulations and procedures for their care will be suggested. The finding and implementation of new ideas will be directed towards entrepreneurship with the aim of economic growth, and further research within new project application.]]></summary_en></project><project>
<id>8070</id><title_hr><![CDATA[Pristup utemeljen na znanju za analizu mnoštva ljudi u nadzornim sustavima]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4290</user_id><user_firstLast_name>Slobodan Ribarić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-9608</code><acronim><![CDATA[KACAVIS]]></acronim><duration>01.03.2019 - 28.02.2023</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>25719</team_members_id><team_members_names><![CDATA[ Doktorand: Franjo Matković ]]></team_members_names><keywords_hr><![CDATA[Analiza mnoštva ljudi, Nadzorni sustav, Sustav temeljen na znanju, Raspoznavanje uzoraka, Analiza ponašanja]]></keywords_hr><keywords_en><![CDATA[Crowd Analysis, Video Surveillance, Knowledge-based, Pattern recognition, Behaviour  Analysis]]></keywords_en><summary_hr><![CDATA[Jedno od trenutno najaktivnijih istraživačkih područja računalnog vida je analiza scena s mnoštvom ljudi (engl. crowd). Mnoštvo se može definirati kao grupa ljudi ili velika skupina pojedinaca okupljenih u istom fizičkom okruženju. Modeliranje mnoštva, analiza scena s mnoštvom i raspoznavanje ponašanja su najzahtjevnije teme računalnog vida i umjetne inteligencije. Znanstveni cilj predloženog istraživanja je razvoj eksperimentalnog inteligentnog sustava utemeljenog na znanju za analizu mnoštva i raspoznavanje ponašanja na temelju vizualnih informacija dobivenih video nadzornim sustavom. Predložen je novi pristup utemeljen na znanju za modeliranje scena s mnoštvom, koji predstavlja spoj metoda utemeljenih na agentima i entitetima, i zdravorazumskog ljudskog znanja. Ideja je pretvoriti ljudsko (ili ekspertno) znanje o ponašanju mnoštva, utemeljeno na vizualnim informacijama, i dodati ga drugim modelima temeljenim na informacijama dobivenim metodama računalnog vida, u bazu znanja koju podržava stroj za zaključivanje. Glavni ciljevi istraživanja su: i) Kritički pregled i analiza ranijih pristupa na području modeliranja i analize mnoštva u sustavima video nadzora; ii) Novi model mnoštva koji se temelji na fuziji agenata i entiteta; iii) Razvijati metode izlučivanja značajki iz videa prilagođene za makroskopsku i mikroskopsku analizu scena s mnoštvom; iv) Pristup modeliranja mnoštva utemeljen na zdravorazumskom znanju; v) Nova arhitektura za hibridno predstavljanje znanja koja kombinira zdravorazumsko ljudsko znanje i koncepte dubokog učenja; vi) Razviti shemu hibridnog predstavljanja znanja te njezinu integraciju s dubokim neuronskim mrežama; vii) klasifikacija ponašanja mnoštva ljudi; viii) Dizajn dubokog modela učenja za analizu scena s mnoštvom; ix) Razvoj eksperimentalnog sustava i njegovo ispitivanje i evaluacija.Važniji ciljevi projekta su diseminacija rezultata istraživanja (tj. objavljivanje časopisa i konferencija) i razvoj karijera mladih istraživača.]]></summary_hr><summary_en><![CDATA[Recently, one of the most active research areas in computer vision is crowd scene analysis. Crowd modelling, crowd scene analysis and behavioural recognition are some of most challenging topics in computer vision and more generally in artificial intelligence. The scientific goal of the proposed research is the development of an experimental intelligent, knowledge-based system for crowd analysis and behaviour recognition based on visual information obtained by video surveillance systems. A proposal is made for a novel knowledge-based approach to modelling crowd scenes, which represents a fusion of agent-based and entity-based approaches, together with human common-sense modelling. The idea is to convert human (or expert) knowledge about crowd behaviour, based on visual information, and to add it to the other models based on information extracted by means of computer vision techniques, in a knowledge base which is supported by an inference engine. The main objectives of the research are: i) to critically review and analyse previous approaches to the field of crowd modelling and analysis in video surveillance systems; ii) to develop a new crowd model based on the fusion of agent-based and entity-based approaches; iii) to develop feature extraction methods from video adapted to macroscopic and microscopic crowd level analyses; iv) to develop a common-sense knowledge approach to crowd modelling; v) to develop a new architecture for hybrid knowledge representation which combines human common-sense knowledge and  deep learning concepts; vi) to develop a hybrid knowledge representation scheme and to integrate it with deep neural networks; vii) to classify crowd behaviour; viii) to design a deep learning model for crowd scene analysis; ix) to develop an experimental system and to test and evaluate it. The important objectives of the project are dissemination (i.e. publishing of journal and conference papers) and young researchers&#39; career development. ]]></summary_en></project><project>
<id>8071</id><title_hr><![CDATA[Mehanizmi nutrijentom posredovanih učinaka endogenog glukagonu sličnog peptida-1 na kognitivne i metaboličke poremećaje u eksperimentalnim modelima neurodegenerativnih bolesti]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1198</user_id><user_firstLast_name>Melita Šalković-Petrišić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-6526</code><acronim><![CDATA[NutrientGLP-1]]></acronim><duration>06.05.2019 - 06.11.2023</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>27148</team_members_id><team_members_names><![CDATA[ Doktorand: Jan Homolak ]]></team_members_names><keywords_hr><![CDATA[glukagonu sličan peptid-1, galaktoza, Alzheimerova bolest, Parkinsonova bolest, streptozotocin, 6-OHDA, kognitivne funkcije]]></keywords_hr><keywords_en><![CDATA[glucagone-like peptide -1, galactose, Alzheimer disease, Parkinson disease, streptozotocin, 6-OHDA, cognition]]></keywords_en><summary_hr><![CDATA[Projekt nastavlja prethodna istraživanja učinaka oralne galaktoze u eksperimentalnoj Alzheimerovoj bolesti (AB) putem detaljne karakterizacije mehanizama terapijskog učinka paralelno u eksperimentalnoj AB i Parkinsonovoj bolesti (PB). Rezultati aktualnog projekta podupiru naše preliminarne rezultate i upućuju da oralne galaktoza ublažava/normalizira kognitivna oštećenja u ranoj patološkoj fazi eksperimentalne sporadične AB (sAB) izazvane intracerebroventrikularnom primjenom streptozotocina u štakora (STZ-icv model). Ovo istraživanje će objediniti dva nova terapijska pristupa u liječenju neurodegenerativnih bolesti, temeljena na glukagonu-sličnom peptidu-1 (GLP-1) i nutrijentima. U netransgeničnim, toksinom izazvanim štakorskim modelima (sAB/STZ-icv model, PB/6-hidroksidopamin, 6-OHDA model) istražit će se učinak endogenog GLP-1 posredovan primjenom oralne galaktoze/nutrijenta. Cilj ovog 4-godišnjeg projekta je ispitati jesu li akutni metabolički/neuroprotektivni učinci jedne doze oralne galaktoze u sAB modelu posredovani samo endogenim GLP-1 ili/i endogenim glukoza-ovisnim inzulinotropnim peptidom (GIP). Također, cilj je ispitati je li terapijski potencijal dugotrajne primjene oralne galaktoze na kognitivna oštećenja, metaboličke i neuropatološke poremećaje u sAB i PB modelima povezan primarno s kompleksnim učincima galaktoze (izravni + inkretinima posredovani učinci) ili se radi samo o inkretinom posredovanim učincima. U 5 akutnih+5 kroničnih pokusa ispitat će se kognitivne i motorne funkcije, te poremećaji homeostaze glukoze/inzulina, te glavna neuropatološka sAB/PB obilježja i parametri signalizacije GLP-1/GIP/inzulina. Projekt će donijeti nove spoznaje i razviti specifični oblik modela-načina liječenja koji nalikuje mogućoj etiopatogenezi ovih bolesti u stvarnom životu.  Rezultati će pridonijeti pojašnjenju terapijskog pristupa sAB/PB temeljenog na GLP-1 lijekovima, a očekivane publikacije povećati kompetitivnost mladih istraživača za buduće projektne prijave. ]]></summary_hr><summary_en><![CDATA[This project aims to continue previous research on oral galactose treatment in experimental Alzheimer’s disease (AD) by in parallel characterizing in depth mechanisms of its therapeutic activity in experimental AD and Parkinson disease (PD). The results of on-going research supported our preliminary data and demonstrated that in the streptozotocin (STZicv)-induced rat model of sAD, oral galactose ameliorates or normalizes cognitive impairment in the early stage of sAD pathology.  By combining glucagon-like peptide-1 (GLP-1)-related and nutrient-based trends in accomplishing desirable neuroprotective effects in the treatment of neurodegenerative disorder, this research will explore oral galactose (nutrient)-promoted activity of endogenous GLP-1 in non-transgenic rat models of toxin-induced sporadic AD (sAD/STZ-icv model) and PD (6-hydroxydopamine, 6-OHDA model). This 4-year project aims to explore whether acute metabolic/neuroprotective effects of a single oral galactose dose in sAD model are mediated by promotion of solely endogenous GLP-1 or/and by endogenous glucose-dependent insulinotropic peptide (GIP), and whether the therapeutic potential of chronic oral galactose treatment on cognitive deficits, metabolic dysfunction and neuropathology in STZ-icv and 6-OHDA models results primarily from the complex galactose-induced effects (direct + incretin-mediated ones) or it is solely the incretin-mediated effect. Cognitive and motor performance and glucose/insulin homeostasis will be explored in 5 acute and 5 chronic experiments accompanied by AD-/PD-neuropathological hallmarks as well as GLP-1/GIP/insulin signalling assessment.  Project will gain new knowledge and establish the specific model-treatment design that mimics more closely the real life situation. The results will contribute to elucidation of GLP-1-based therapeutic approach in AD/PD treatment. Expected publications will increase competitiveness of young researches in future grant applications.]]></summary_en></project><project>
<id>8072</id><title_hr><![CDATA[Funkcija novo-otkrivenog proteina u mozgu, urogvanilina, od stanične fiziologije do ljudskog zdravlja]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5255</user_id><user_firstLast_name>Aleksandra Dugandžić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-1176</code><acronim><![CDATA[FURNACE/FURNACE]]></acronim><duration></duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>26210</team_members_id><team_members_names><![CDATA[ Doktorand: Ines Drvar ]]></team_members_names><keywords_hr><![CDATA[elektrofiziološka istraživanja, hipotalamus, smeđe masno tkivo, klinička istraživanja, infracrvena termografija]]></keywords_hr><keywords_en><![CDATA[patch clamp, hypothalamus, brown adipose tissue, clinical studies, infrared thermography]]></keywords_en><summary_hr><![CDATA[Diabetes mellitus tipa 2 (T2DM) i komplikacije veliki su teret za današnje čovječanstvo. Komplikacije ove bolesti koje nastaju zbog hiperglikemije godišnje uzrokuju smrt oko 3,4 milijuna ljudi u svijetu. Novi pristup ovom problemu bio bi porast potrošnje glukoze putem aktivacije smeđeg masnog tkiva (BAT) putem regulacije središnjim živčanim sustavom. BAT pretvara glukozu nakon obroka u toplinu. Nedavno smo otkrili novi protein u mozgu, urogvanilin (UGN), čiji izražaj se mijenja nakon unosa hrane te promjene u njegovoj funkciji u mozgu mijenja aktivnost BAT-a. Cilj ovog projekta je odrediti funkciju UGN-a u mozgu i njegovu ulogu u fiziologiji BAT-a. To će biti istraženo na staničnoj razini (elektrofiziološka istraživanja), na životinjskom modelu te na zdravoj i T2DM populaciji. Specifični ciljevi ovog projekta su odrediti: mehanizam djelovanja UGN-a u hipotalamusu, regulacija stvaranja UGN-a u mozgu i promjene volumena i aktivnosti BAT-a nakon produljene primjene UGN-a. Usporedit ćemo ulogu UGN-a u regulaciji aktivnosti BAT-a kod oboljelih od T2DM i zdravih ispitanika mjerenjem aktivnosti BAT-a nakon obroka. Ta aktivnost biti će uspoređena s promjenama u homeostazi glukoze i sintezom inzulina, glukagonu sličnog peptida-1 (GLP-1) i UGN-a. Moguć utjecaj dobi, spola i tjelesne težine na moždane učinke UGN-a biti će određeni procjenom izražaja njegovog receptora u različitim regijama ljudskog mozga. Aktivnost BAT-a nakon obroka biti će određena jednostavnom, neinvazivnom, ali dovoljno osjetljivom infracrvenom termografijom. Svi pokusi biti će izvedeni na oba spola zbog toga što postoje velike razlike u metabolizmu glukoze između muškaraca i žena koje još nisu u potpunosti razjašnjene. Ovo istraživanje moglo bi dovesti do novog pristupa liječenju hiperglikemije kod oboljelih od T2DM koje bi poboljšalo metabolizam glukoze, smanjilo komplikacije dijabetesa, odgodilo terapiju inzulinom, smanjilo troškove liječenja te sveukupno unaprijedilo kvalitetu života oboljelih od T2DM.]]></summary_hr><summary_en><![CDATA[Type 2 Diabetes mellitus (T2DM) and its complications are great burden for humanity today. Diabetic complications due to hyperglycaemia cause death to about 3.4 million people worldwide yearly. A new approach to maintain glucose homeostasis in T2DM patients is to increase the glucose consumption by an activation of brown adipose tissue (BAT) via central nervous system. BAT converts glucose to heat after a meal. Recently, we discovered a new protein in the brain, uroguanylin (UGN), which expression is regulated by food intake and its brain function changes BAT activity. The goal of our project is to determine the function of UGN in the brain and its role on BAT physiology. They will be investigated at cellular level (electrophysiological research), animal model and in healthy and T2DM human population. The specific aims of this study are: to determine mechanism of UGN action in the hypothalamus, regulation of UGN synthesis in the brain, BAT volume and activity after prolonged UGN administration. The importance of UGN in regulation of BAT function in humans will be established by measuring of BAT activity after a meal and compared to glucose homeostasis and production of insulin, glucagon-like peptide-1, and UGN. The possible influence of age, gender and body weight on brain UGN effects will be determined by estimation of expression of UGN receptor in different human brain regions. BAT activity after a meal will be determined by simple non-invasive but more sensitive infrared thermography. All experiments will be performed in both genders, since there is a huge difference in glucose metabolism in male and female patients which are still not explained. This study could lead to development of a new approach in treatment of hyperglycaemia in T2DM patients, which will improve glucose metabolism, decrease diabetic complications, postpone insulin application, decrease medical expenses and overall improve the quality of life of patients with T2DM.]]></summary_en></project><project>
<id>8073</id><title_hr><![CDATA[Reprogramiranje homeostaze i regeneracije kože uporabom nove tehnike mikro-transplantacije stanica]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1396</user_id><user_firstLast_name>Ivica Rubelj</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-5184</code><acronim><![CDATA[REPROSKIN]]></acronim><duration>08.05.2019 - 07.05.2023</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>27530</team_members_id><team_members_names><![CDATA[ Doktorand: Andrea Cedilak ]]></team_members_names><keywords_hr><![CDATA[starenje, regeneracija, starenje kože, mikro-transplantacija, tkivna homeostaza, SASP]]></keywords_hr><keywords_en><![CDATA[aging, regeneration, skin aging, micro-transplantation, tissue homeostasis, SASP]]></keywords_en><summary_hr><![CDATA[Nakupljanje starih stanica u tkivima je glavni katalizator starenja kod ljudi. Stare stanice imaju promijenjenu ekspresiju gena, karakteriziranu porastom sekrecije citokina, kemokina i ekstracelularnih proteinaza, poznatih kao senescence-associated secretory phenotype (SASP). SASP negativno utječe na homeostazu kože i epidermalne matične stanice (ESC). Ekspresija enzima telomeraze sprječava starenje stanica i održava njihov mladi fenotip. U ovom projektu ćemo istražiti mogučnost za regeneraciju i pomlađivanje kože pomoću tehnike mikrotransplantacije stanica. Analizirat ćemo promjene u koži nakon povečanja udjela mladih ili pomlađenih zdravih stanica na modelu štakora te na modelu ljudskih organotipskih epidermalnih kultura. To će se postići značajnim povečanjem postotka (> 35%, do 55%) mladih stanica ili telomerazom revitaliziranih stanica u koži. Očekujemo da će doći do povećanja regenerativne sposobnosti dermisa i epidermisa, kao i povećanja aktivnosti epidermalnih matičnih stanica. Osim starenja, različiti genetski poremećaji mogu poremetiti zaštitnu funkciju kože. Među najtežim takvim poremećajima je Epidermoliza bullosa (EB). EB je heterogena skupina nasljednih poremećaja kože uzrokovanih mutacijama u 18 različitih gena važnih za dermalno-epidermalne veze, među kojima je i kolagen VII (C7) koji učvršćuje bazalnu membranu. Štakori koji nose takve mutacije imaju krhku kožu sklonu guljenju koja ujedno pokazuje sve glavne karakteristike EB kod ljudi. Stoga ćemo također analizirati promjene u koži EB štakora nakon povećanja udjela stanica koje nose divlji tip C7. Do sada smo uspostavili protokol za mikrotransplantaciju stanica u tkivo kože koji nam omogućuje manipulaciju raznim staničnim tipovima. Glavni cilj ovog projekta je izravno pokazati da je moguće mijenjati stanični sastav kože i time utjecati na metabolički profil lokalnog tkiva, poboljšati aktivnost matičnih stanica in vivo te time povećati regeneraciju kože.]]></summary_hr><summary_en><![CDATA[Accumulation of senescent cells in tissues is the main catalyst of aging in humans. Old cells have altered gene expression, highlighted by a strong increase in secreted cytokines, chemokines and extracellular proteinases known as the senescence-associated secretory phenotype (SASP) which has a negative impact on skin and epidermal stem cells (ESC). Expression of the enzyme telomerase prevents cell aging and maintains their young phenotype. In this project we will explore the potential for skin regeneration and rejuvenation by using a cell micro-seeding technique. We will analyse changes in the skin following an increase in proportion of young or rejuvenated healthy cells in a rat skin model and in human organotypic epidermal equivalent model. This will be achieved by introducing a large proportion (>35%, up to 55%) of young cells or telomerase revitalized cells into skin. We expect to observe increase in regenerative capacity of dermis and epidermis as well as increase in ESC viability. Besides aging, various genetic disorders can disrupt protective function of the skin. Among most severe of such disorders is Epidermolysis bullosa (EB). EB is a heterogeneous group of hereditary skin fragility disorders caused by mutations in 18 different genes important for dermal-epidermal connections, among which is Collagen VII (C7) that anchor the basal membrane. Affected animals have fragile and blister-prone skin showing all major signs of EB in humans. Therefore we will also analyse changes in the EB rat skin following an increase in proportion of cells carrying wild type C7. So far we have established a protocol for micro-transplantation of cells into skin tissue which allows for manipulation of various cell populations. The main objective of this project is to directly show that it is possible to alter the cellular composition of tissues and with that alter the local tissue metabolic profile, improve viability of ESC in vivo and increase skin healing and regeneration.]]></summary_en></project><project>
<id>8074</id><title_hr><![CDATA[Intenzifikacija fotokatalitičkih i katalitičkih procesa za obradu otpadnih voda i otpadnih plinova]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3295</user_id><user_firstLast_name>Vesna  Tomašić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-7215</code><acronim><![CDATA[IN-PhotoCat]]></acronim><duration>11.02.2019 - 10.02.2023</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Kemijsko inženjerstvo, </scie_field_hr><scie_field_en>Chemical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet kemijskog inženjerstva i tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Chemical Engineering and Technology]]></institution_en><team_members_id>25646</team_members_id><team_members_names><![CDATA[ Doktorand: Filip Car ]]></team_members_names><keywords_hr><![CDATA[intenzifikacija procesa, heterogena fotokataliza, monolitni reraktori, neonikotinoidni insekticidi, aromatski hlapljivi organski spojevi]]></keywords_hr><keywords_en><![CDATA[process intensification, heterogeneous photocatalysis, monolithic reactors, neonicotinoidic insecticides, aromatic volatile compounds]]></keywords_en><summary_hr><![CDATA[Znanstvenici i inženjeri na uglednim sveučilištima i industrijskim istraživačkim centrima intenzivno rade na otkriću novih procesnih uređaja i tehnika, koji će predstavljati velik iskorak u odnosu na dosadašnja saznanja o kemijskim procesnim postrojenjima i omogućiti razvoj integriranih, sigurnijih, energetski učinovitijih i ekološki prihvatljivijih tehnologija. Zahvaljujući snažnom razvoju znanosti i sve većem interesu javnosti za ovo područje, intenzifikacija procesa postepeno se počinje izdvajati kao nova disciplina unutar kemijskog inženjerstva. Cilj predloženog projekta je razvoj novih fotokatalizatora i katalizatora te inovativnih izvedbi fotokatalitičkih i katalitičkih reaktora primjenom temeljne metodologije kemijskog inženjerstva i osnovnih načela intenzifikacije procesa s ciljem njihove primjene za rješavanje globalnih problema vezanih uz obradu otpadnih voda i otpadnih plinova te izrade odgovarajućih prototipova reaktora. Aktivnosti na projektu obuhvaćat će dva katalitička sustava: fotokatalitičku razgradnju neonikotinoidnih insekticida na novim fotokatalizatorima s povećanom aktivnošću u vidljivom dijelu sunčevog spektra i heterogenu katalitičku oksidaciju smjese aromatskih hlapljivih organskih spojeva (BTEX) u plinskoj fazi u keramičkim monolitnim reaktorima. Izvornost i značaj predloženog projekta za hrvatsku javnost i njezinu promociju u svijetu očituje se u razvoju inovativnih tehnologija zaštite okoliša s visokim potencijalom za transfer takvih tehnologija u realne sustave te u usmjerenosti predloženog projekta na stjecanje novih znanja, vještina i osposobljavanje mladih istraživača. Rezultati projekta bit će prezentirani na domaćim i međunarodnim znanstvenim skupovima što će hrvatskim znanstvenicima osigurati veću vidljivost i omogućiti sudjelovanje na kompetitivnim međunarodnim projektima iz navedenog područja.]]></summary_hr><summary_en><![CDATA[Scientists and engineers at renowned universities and industrial research centers are working intensively on the discovery of new process equipment and techniques, which will represent a major breakthrough in relation to existing knowledge of chemical process facilities and enable the development of integrated, safer, more energy-efficient and environmentally-friendly technologies. Thanks to the strong development of science and the growing interest of the public in this area, the process intensification gradually begins to emerge as a new discipline within chemical engineering. The aim of the proposed project is the development of new photocatalysts and catalysts as well as innovative performance of photocatalytic and catalytic reactors using the basic methodology of chemical engineering and basic principles of process intensification. The goal is in their potential application to solve global problems related to the wastewater and waste gases treatment and design of appropriate prototypes of reactors. Project activities will include two catalytic systems: photocatalytic degradation of neonicotinoid insecticides on new photocatalysts with increased activity in the visible part of the solar spectrum and heterogeneous catalytic oxidation of the mixture of aromatic organic compounds (BTEX) in the gas phase in various designs of ceramic monolithic reactors. The originality and significance of the proposed project for the Croatian public and its promotion in the world is reflected in the development of innovative environmental technologies with high potential for technology transfer to the realistic systems as well as in focusing of the proposed project to acquire new knowledge, skills and training of young researchers. The results of the project will be presented at national and international scientific conferences, which will enable Croatian scientists to gain greater visibility and enable participation in competitive international projects from the mentioned area.]]></summary_en></project><project>
<id>8075</id><title_hr><![CDATA[Nove Strategije Za Pripravu Tetrasupstituiranih Kiralnih Centara: Asimetrične Katalitičke Reakcije Usmjerene Protuanionom]]></title_hr><title_en><![CDATA[]]></title_en><user_id>558</user_id><user_firstLast_name>Matija Gredičak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-3656</code><acronim><![CDATA[NSYNC-ACDC]]></acronim><duration>05.04.2019 - 05.09.2023</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>27441</team_members_id><team_members_names><![CDATA[ Doktorand: Arben Beriša ]]></team_members_names><keywords_hr><![CDATA[ACDC, organska sinteza, asimetrična organokataliza, kiralne Bronstedove kiseline, tetrasupstituirani kiralni centri]]></keywords_hr><keywords_en><![CDATA[ACDC, organic synthesis, asymmetric organocatalysis, chiral Bronsted acids, tetrasubstituted chiral centers]]></keywords_en><summary_hr><![CDATA[Jedan od primarnih zadataka sintetske organske kemije je razvoj kemijskih reakcija koje na kontrolirani način selektivno omogućuju molekulsku raznolikost. Stoga je od velikog značaja razvoj novih metoda za visoko selektivne i specifične priprave složenih spojeva. Prilikom razvoja takvih metoda, jedan od najvećih izazova kemičarima predstavlja priprava kiralnih tetrasupstituiranih stereogenih centara. Iako je moderna sintetska kemija opremila kemičare nizom metoda za savladavanje najsloženijih sintetskih problema, takvi su protokoli često skupi i vremenski zahtjevni. S druge strane, Priroda takve procese obavlja s lakoćom upotrebom enzima – složenih strojeva usavršavanih milijunima godina evolucije. Cilj ovog projekta je razvoj istraživačkog programa za oponašanje Prirode i enzima korištenjem asimetričnih organokatalitičkih reakcija, s ciljem kontroliranja selektivnog i specifičnog nastajanja složenih struktura koji u sebi sadrže tetrasupstituirane stereogene centre kao aktivne strukturne podjedinice.Nastajanje novih kemijskih veza temeljit će se na strategiji ionskih parova, konceptu koji je već primjenjen u seriji asimetričnih transformacija, no koji je ograničen relativno niskom aktivacijom početnih spojeva. Kako bi se omogućila aktivacija takvih sustava, projektom se predlaže proširenje koncepta ionskih parova na asimetrične katalitičke reakcije usmjerene protuanionom (eng. asymmetric counteranion-directed catalysis, ACDC). Na taj bi se način omogućila priprava složenih strukturnih kostura koji se trenutno mogu dobiti isključivo primjenom zahtjevnih, skupih i nepraktičnih protokola. Projektom se predviđa razvoj asimetričnih metoda za pripravu tetrasupstituiranih stereogenih centara korištenjem ACDC strategije, s posljedičnim ciljem razvoja učinkovitije katalize nekovalentnim interakcijama. Projekt pruža mogućnost za istraživanje i primjenu čitavog niza katalitičkih asimetričnih organskih reakcija za koje trenutno ne postoji presedan.     ]]></summary_hr><summary_en><![CDATA[One of the primary goals of synthetic organic chemistry is the development of chemical reactions that selectively introduce molecular diversity in a controlled manner. In this regard, the development of novel methods for highly selective and specific syntheses of complex materials is of great importance. In the development of these novel methods, one of the biggest challenges presented to chemists is the construction of tetrasubstituted stereogenic centers. Although modern chemistry offers access to a plethora of tools to tackle the most complex total syntheses, these processes are expensive and time consuming. On the other hand, Nature effortlessly performs these tasks by employing enzymes – complex machines perfected through millions of years of evolution.In this proposal, we aim to emulate Nature through asymmetric catalysis in order to develop selective and specific protocols for the construction of complex materials comprising tetrasubstituted stereogenic centres as active structural subunits. We plan to base our new strategic bond forming reactions on ion pairing strategy. This principle has already been exploited in the range of elegant selective asymmetric transformations, but can be limited by relatively low levels of activation offered by these materials. In order to achieve activation of such systems, we plan to extend the principle of ion–binding in catalysis by employing asymmetric counteranion–directed catalysis (ACDC). This is an important task as it will allow formation of demandingstructural motifs that are currently difficult to produce. This proposal aims to develop transformations for the generation of complex materials with chiral tetrasubstituted centers by employing ACDC strategies, and lead to the development of more efficient catalyst systems that operate through non–covalent interactions. The project offers a rare opportunity to investigate and exploit an entire manifold of unprecedented catalytic asymmetric organic reactions.]]></summary_en></project><project>
<id>8076</id><title_hr><![CDATA[Imunosni mehanizmi u razvoju upale i metaboličkog sindroma u debljini]]></title_hr><title_en><![CDATA[]]></title_en><user_id>7082</user_id><user_firstLast_name>Bojan Polić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-8638</code><acronim><![CDATA[INFLAMETAB]]></acronim><duration>01.06.2020 - 01.01.2024</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Medicine]]></institution_en><team_members_id>856079</team_members_id><team_members_names><![CDATA[ Doktorand: Karlo Mladenić ]]></team_members_names><keywords_hr><![CDATA[Upala, Debljina, Rezistencija na inzulin, metabolički sindrom, diabetes, NASH,  stanice NK, urođeni limfociti, gamma delta limfociti T, citokini]]></keywords_hr><keywords_en><![CDATA[Inflammation, Obesity, Insuline resistance, Metabolic Syndrome, diabetes, NASH, NK cells, ILCs, gamma delta T cells, macrophages, cytokines]]></keywords_en><summary_hr><![CDATA[Pretilost je jedan od najznačajnijih i rastućih medicinskih zdravstvenih problema današnjice. Procjenjuje se da trenutno na svijetu živi više od pola milijarde debelih ljudi i  preko milijarde onih s prekomjernom težinom. Značajan broj njih oboljeva od šećerne bolesti tipa 2 (DM2) i nealkoholne bolesti masne jetre (NAFLD), koje često koegzistirjau i dijele patogene abnormalnosti debljine kao što su rezistencija na inzulin (IR), dislipidemija i hipertenzija, što su karakteristike metaboličkog sindroma. Debljina je povezana sa kroničnom sistemskom upalom niskog intenziteta za koju se smatra da je važan pozadinski uzrok IR, koja dovodi do DM2 i NAFLD. Ciljanje mehanizama upale u obje bolesti je stoga obećavajuće za buduće pristupe u terapiji. No, stvarni mehanizmi koji induciraju ili pogoršavaju upalu u debljini i uzrokuju prijelaz iz stadija pre-dijabetesa u DM2 ili iz stadija jetrene steatoze u nealkoholni steatohepatitis (NASH) su još uvjek uglavnom nejasni. Stoga je bolje poznavanje imunosnih uzroka DM2-a i NASH-a neophodno potrebno. U ovom projektu namjeravamo istražiti imunosne mehanizme koji su važni za indukciju upalnih procesa u visceralnom masnom tkivu (VAT) i jetri, te su odgovorni za razvoj DM2 i NASH. Dodatno, naš cilj je istražiti virusne faktore koji pogoršavaju IR i imaju učinak na tranziciju iz pre-dijabetesa u DM2. U ovoj studiji koristi ćemo dobro pozate mišje modele dijetom inducirane debljine (DIO), te odgovarajuće mišje mutante i druga oruđa kako bismo odgovorili na postaljena pitanja. Isto tako, usporediti ćemo eksperimentalne podatke sa podacima analize uzoraka sakupljenih od pretilih bolesnika što je također planirano projektom. Ovaj projekt povezuje imunologiju, virologiju i endokrinologiju. Istraživački tim ima dovoljno iskustva i znanja za uspješno provođenje predloženog istraživanja, te će bti sposoban stvoriti nova vrijedna i korisna saznanja o razvoju DM2-a i NASH-a. ]]></summary_hr><summary_en><![CDATA[Obesity is one of the most prominent and growing health problem of our time. It is estimated that more than a half billion of obese and another billion of overweight people live currently in the world. A significant number of them develop Diabetes Mellitus type 2 (DM2) and Non-alcoholic Fatty Liver Disease (NAFLD), which often coexist and share pathogenic abnormalities of obesity like insulin resistance (IR), dyslipidaemia and hypertension, which are features of the metabolic syndrome. Obesity is associated with a chronic systemic low-grade inflammation which is thought to be an important underlying cause of IR that leads to DM2 and NAFLD. Targeting of the underlying mechanisms of inflammation in both diseases therefore holds much promise for future therapies. However, the exact mechanisms that induce or aggravate inflammation and trigger transition from pre-diabetes to DM2 or from hepatic steatosis to non-alcoholic steatohepatitis (NASH) in obesity are still largely unclear. A better understanding of immunological causes of DM2 and NASH is therefore required.In this project we aim to investigate immune mechanisms that are important for induction of inflammatory processes in visceral adipose tissue (VAT) and liver, which are responsible for development of DM2 and NASH. In addition, our goal is to investigate viral factors that aggravate IR such as impact progression from pre-diabetes to DM2. In our study we will use well established mouse models of diet induced obesity (DIO) and appropriate mouse mutants and tools to address raised questions. We will compare experimental data with the analysis of samples collected from obese human subjects also planned in the project. Our project bridges immunology, virology and endocrinology. Our team has enough experience and expertise to drive successfully proposed research and will be able to provide valuable new insights in the development of DM2 and NASH. ]]></summary_en></project><project>
<id>8077</id><title_hr><![CDATA[Hrvatska longitudinalna studija tjelesne aktivnosti u adolescenciji]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6355</user_id><user_firstLast_name>Tatjana Trošt Bobić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-3125</code><acronim><![CDATA[CRO-PALS]]></acronim><duration></duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Kineziologija, </scie_field_hr><scie_field_en>Kinesiology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Kineziološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Kinesiology]]></institution_en><team_members_id>28634</team_members_id><team_members_names><![CDATA[ Doktorand: Marija Martina Glavaš ]]></team_members_names><keywords_hr><![CDATA[tjelesna neaktivnost, zdravlje, pretilost, sedntarna ponašanja, mladež]]></keywords_hr><keywords_en><![CDATA[inactivity, health, obesity, sedentarism, youth]]></keywords_en><summary_hr><![CDATA[Nedovoljna tjelesna aktivnost (TA) na četvrtom je mjestuvodećih rizika smrtnosti u svijetu. Tijekom adolescencijesmanjuje se u oba spola, a determinante i ishodi tog smanjenjanisu u potpunosti razjašnjeni. Stoga su ciljevi ovog istraživanja:analizirati obrasce promjena TA tijekom adolescencije; identificirati determinante TA i sedentarnih ponašanja tijekom ovog razdoblja; istražiti povezanost TA i sedentarnih ponašanja sa nekim sa zdravljem povezanim ishodima; identificirati moderatore tih povezanosti. Ovaj projekt se naslanja na tekuće longitudinalno istraživanje koje je započelo 2014. godine, a obuhvaća  903 učenika iz 14 slučajno odabranih zagrebačkih srednjih škola. TA i sedentarna ponašanja se procijenjuju SHAPES upitnikom i pomoću multisenzornog monitora TA (the SenseWear Armband).Za evaluaciju motivacije koristit se &#39;The Motives for Physical Activity Measure- Revised&#39; upitnik. Trajanje spavanja ispituje se SWA monitorom i upitnikom. Dijetetske metode uključuju 24-h prisjećanje unosa hrane i upitnik o učestalosti unosa hrane. BMI, WHR i % tjelesne masti računaju se temeljem antropometrije.Krvni tlak mjeri se u skladu s ESH preporukama, a pušenje i socio-ekonomski faktori procijenjuju se upitnicima. Subjektivni osjećaj zdravlja ispituje se hrvatskom verzijom upitnika KIDSCREEN-27, a koncept mentalnog zdravlja primjenom &#39;&#39;TheStrengths and Difficulties Questionnaire&#39;&#39;. Mjeru školskog uspjeha čini prosjek ocjena na kraju školske godine. Obrada podataka temeljit će se većinom na višerazinskom modeliranju za ponavljana mjerenja. Rezultati ovog projekta omogućit će bolje razumijevanje determinanti i moderatora TA i sedentarnih ponašanja u mladih. Nadalje, rasvijetlit će se relativna uloga TA i sedentarnih ponašanja u povezanostima sa zdravstvenim ishodima, što će doprinijeti i znanstveno utemeljenom planiranju ciljanih intervencijskih programa primarne prevencije kroničnih bolesti.]]></summary_hr><summary_en><![CDATA[Lack of physical (PA) is recognized as the fourth leading risk for global death. During adolescence PA declines in both genders. Still, determinants and outcomes of this decline remain to be clarified. The aims of this study are: to analyze patterns ofchange in PA during adolescence; to identify determinants and moderators of PA and sedentary behaviours in this period; to explore the effect of PA and sedentary behaviours on several health related outcomes; to examine how different correlates of PA moderate the effect of PA and sedentary behaviours on health-related outcomes. The project extends on the on-going prospective longitudinal study that started in 2014 and involves around 900 high school students from the city of Zagreb (Croatia). PA and sedentary behaviours are assessed annually during 4 years of high school education by the SHAPES questionnaire and by the SenseWear Armband multiple-sensor activity monitor. Motivation for PA is evaluated by &#39;The Motives for Physical Activity Measure - Revised&#39; and perceived health by the KIDSCREEN-27 questionnaire. Sleep is examined using several self-report instruments and by the SWA monitor. The 24-h dietary recall and a food frequency questionnaire are applied. BMI, WHR and body fat percentage will be calculated based on anthropometry. Blood pressure is  taken following ESH guidelines. Smoking and socioeconomic factors will be assessed through questionnaires. Mental health is evaluated by the Strengths and Difficulties Questionnaire; grade point average will be used as a measure of academic achievement. Data analytic techniques will mostly rely on multi-level modelling for repeated measures. The results of this study will aid in understanding PA decline in youth, its determinants and moderators. In addition, the relative importance of PA and sedentary behaviours for physical and mental health will be elucidated. Consequently, future interventions aimed at primary prevention of chronic diseases will be improved.]]></summary_en></project><project>
<id>8078</id><title_hr><![CDATA[Europski korijeni moderne Hrvatske: transfer ideja na političkom i kulturnom polju u 18. i 19. stoljeću ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1526</user_id><user_firstLast_name>Vlasta Švoger</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-2672</code><acronim><![CDATA[EuKor]]></acronim><duration>01.02.2019 - 01.12.2023</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Povijest, </scie_field_hr><scie_field_en>History, </scie_field_en><institution_hr><![CDATA[Hrvatski institut za povijest]]></institution_hr><institution_en><![CDATA[Croatian Institute of History]]></institution_en><team_members_id>23699</team_members_id><team_members_names><![CDATA[ Doktorand: Zrinko Novosel ]]></team_members_names><keywords_hr><![CDATA[Hrvatska, (proto)modernizacija, transfer ideja, europski utjecaji, 18. i 19. stoljeće, intelektualna povijest, povijest institucija]]></keywords_hr><keywords_en><![CDATA[Croatia, (proto)modernisation, transfer of ideas, European influences, 18th and 19th centuries, intellectual history, history of institutions]]></keywords_en><summary_hr><![CDATA[Polazeći od hipoteze da su temelji za izgradnju Hrvatske kao moderne države postavljeni tijekom 18. i „dugog“ 19. stoljeća cilj projekta je istražiti transfer i recepciju različitih ideja i idejnih strujanja europske provenijencije u političkom i kulturnom životu Hrvatske koje su pridonijele oblikovanju europskog identiteta Hrvatske i njezinom preoblikovanju u modernu državu. Istraživanja će polaziti od rubnog geopolitičkog položaja hrvatskih zemalja koji je stoljećima bilo sjecište putova i civilizacijskih okvira - mediteranskog, zapadnoeuropskog i euroazijskog - i analizirat će na koji je način on utjecao na transfer političkih i kulturnih ideja iz drugih europskih zemalja. Istraživanjem će se nastojati rekonstruirati korelacije između novih europskih ideja i hrvatskih tradicionalnih političkih i kulturnih obrazaca. Propitivat će se europski idejni utjecaji na razvoj parlamentarnog sustava i parlamentarne kulture u Hrvatskoj, na postavljanje temelja moderne javne uprave, javnozdravstvenog sustava i školstva te na transfer ideja na području privatnog prava i književnosti. Istraživat će se i veze istaknutih europskih intelektualaca s nekim uglednim hrvatskim političkim i kulturnim djelatnicima. Istraživanje će se temeljiti na komparativnoj metodi i studijama slučaja (case studies) koje će se interpretirati primjenom teorije kulturnog transfera i drugih translacijskih teorija. Projekt će rezultirati nizom znanstvenih radova u međunarodno indeksiranom časopisima i zbornicima, dvjema e-knjigama i digitalnim repozitorijem koji će biti javno dostupni na mrežnoj stranici projekta te organiziranjem nekoliko znanstvenih kolokvija uz sudjelovanje relevantnih inozemnih i domaćih stručnjaka. ]]></summary_hr><summary_en><![CDATA[Proceeding from a hypothesis that the foundations of Croatia as a modern state were laid in the 18th and “long” 19th centuries, the objective of the project is to research into the transfer and reception of various ideas and the influence of ideas of European provenance in Croatia’s political and cultural life, which contributed to the shaping of Croatia’s European identity and its transformation into a modern state. The research will proceed from the peripheral location of Croatian Lands, which has been for centuries at the junction of ways and at the boundary of different civilisations – Mediterranean, West European, and Euro-Asian. Moreover, it will analyse in what way this location influenced the transfer of political and cultural ideas from other European countries. The researches will primarily focus on the analysis of the correlations between new European ideas and traditional Croatian political and cultural patterns. The influence of European ideas will be questioned on development of parliamentary system and culture in Croatia, on laying foundations for modern public administration, public health care system and school system, and on transfer of ideas in private law and literature. The object of the analysis will also be links between distinguished European intellectuals and some reputable Croatian political and cultural figures. The research will be based on the comparative method and case studies, which will be interpreted applying the theory of cultural transfer and other translation theories. The project will result in a sizeable number of scientific papers in internationally indexed journals and in edited books, two e-books and a digital repository publicly accessible at the project’s web-site, as well as in organisation of several scientific colloquia with the participation of relevant foreign and domestic experts.]]></summary_en></project><project>
<id>8079</id><title_hr><![CDATA[Studija važnosti spinskih međudjelovanja  kao osnova za nove pristupe u istraživanju materijala]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1213</user_id><user_firstLast_name>Dalibor Merunka</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-6246</code><acronim><![CDATA[SPES]]></acronim><duration>16.09.2019 - 25.07.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>28786</team_members_id><team_members_names><![CDATA[ Doktorand: Jakov Slade ]]></team_members_names><keywords_hr><![CDATA[dekoherencija spina elektrona, molekulski magneti,rotacijska i translacijska dinamika u tekućinama, ESR, HF-ESR]]></keywords_hr><keywords_en><![CDATA[electron spin decoherence, molecular magnets, rotational and translational dynamics in liquids, ESR, HF-ESR]]></keywords_en><summary_hr><![CDATA[Spin elektrona predstavlja osjetljivu lokalnu probu okoline u kojoj se nalazi te sudjeluje u jakim/slabim magnetskim spregama. Te se sprege mogu detaljno proučavati spektroskopijom elektronske spinske rezonancije (ESR). U okviru ovog projektnog prijedloga primijenit će se tehnička postignuća impulsne ESR instrumentacije te ESR spektrometara koji koriste visoke frekvencije/magnetska polja u svrhu dobivanja novih spoznaja o svojstvima promatranih materijala. Otvorena pitanja, koja su izabrana kao ciljevi istraživanja u ovom projektnom prijedlogu, su: a) kako kontrolirati dekoherenciju elektronskih spinova u krutini gdje odlučujući utjecaj ima dinamika mnoštva nuklearnih spinova. U središtu interesa ovog pitanja je hiperfina interakcija kao uzrok nuklearne spektralne difuzije. Sustavi u kojima dominira ovaj mehanizam raspada fazne memorije elektronskih spinova bit će izabrani kao prikladni eksperimentalni modelni sustavi. Primijenit će se različite tehnike dinamičkog razsprezanja u svrhu spoznaje kako se na fizičko stanje krute matrice (staklasto ili kristalinično) može zaključiti iz mjerenja vremena fazne memorije;b) kako opisati magnetska međudjelovanja i uređenje u kristalnoj strukturi molekulskog magneta (metalo-organske mreže, koordinacijski polimeri, kompleksi prijelaznih metala);c) kako dobiti informaciju o rotacijskoj i translacijskoj dinamici paramagnetskih molekula u tekućinama uzimajući u obzir sve efekte hiperfinog i dipolarnog međudjelovanja te međudjelovanja izmjene na pripadajuće ESR spektre.Te tri netrivijalne teme, koje uključuju proučavanje spinskih međudjelovanja elektrona u amorfnim i kristaliničnim materijalima te tekućinama, imaju za cilj proširenje granica koje imaju postojeći teorijski modeli. Također, očekivani cilj je i da se pravilnom manipulacijom i kontrolom spinskih stanja elektrona u ESR eksperimentu omogući dobivanje što više informacija iz spektralne analize, te, ako je moguće, utječe i na svojstva/dizajn materijala.]]></summary_hr><summary_en><![CDATA[Electron spin represents sensitive local probe of its environment and, thus, experiences strong/weak magnetic couplings. These can be thoroughly studied by electron spin resonance spectroscopy (ESR). In this context technical developments regarding pulsed/high magnetic field ESR spectrometers will be exploited in order to achieve new insight into the properties of the material under investigation. Therefore, within this project proposal several open questions are to be addressed: a) how to control the electron spin decoherence in a solid material when nuclear spin bath dynamics is a determining factor. Here, the hyperfine interaction in terms of nuclear spectral diffusion is in the focus of interest. Experimental model systems in which this channel of electron spin phase memory time decay is dominant will be purposely tailored; b) how to describe magnetic interactions in the crystal structure containing transition metal centres (metal-organic frameworks, coordination polymers);c) how to get information about rotational and translational dynamics of paramagnetic molecules in liquid systems by taking fully into account the effects of hyperfine, exchange, and dipolar interactions on their ESR spectra. These three non-trivial experimental tasks to be performed in amorphous, liquid and crystalline materials aim to extend the current limits of the existing theoretical models of electron spin-spin interactions. The expected goal is to extract as much as possible information from the ESR spectral analyses by proper manipulation of the electron spin states in an ESR experiment and possibly paw the way to influence the properties/design of materials. ]]></summary_en></project><project>
<id>8080</id><title_hr><![CDATA[Prilagodba uzgoja bijele ribe klimatskim promjenama]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5520</user_id><user_firstLast_name>Tin Klanjscek</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-4671</code><acronim><![CDATA[AqADAPT]]></acronim><duration>01.04.2019 - 01.10.2023</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Interdisciplinarne prirodne znanosti, </scie_field_hr><scie_field_en>Interdisciplinary natural sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>23207</team_members_id><team_members_names><![CDATA[ Doktorand: Ines Haberle ]]></team_members_names><keywords_hr><![CDATA[modeliranje rasta riba, prilagodba agrikulture klimatskim promjenama, sedimenti, vodeni stupac, zdravlje riba, radiokronologija, frakcionacija izotopa]]></keywords_hr><keywords_en><![CDATA[modelling fish growth, adaptation of agriculture to climate change, sediment, water column, fish health, radiochronology, isotope fractionation]]></keywords_en><summary_hr><![CDATA[Uzgoj bijele ribe predstavlja važnu gospodarsku granu u Hrvatskoj sa značajnim potencijalom za rast. Budući da se uzgoj pretežno odvija u priobalnim kavezima ovisnim o uvjetima okoliša, rast i zdravlje riba, a samim time i proizvodnja, podložnisu klimatskim promjenama. Klimatske promjene i njihovi utjecaji postaju sve vidljiviji, te ugrožavaju opstojnost i razvoj akvakulture. Predloženi projekt će provođenjem temeljnih istraživanja prirodnih procesa i primjenom rezultata na biotehnologiju uzgoja riba te uz uspostavu baze znanja, doprinjeti stvaranju prilika za poboljšanje proizvodnje i smanjiti ugroze zbog utjecaja klimatskih promjena. Istraživanje će započeti identifikacijom najznačajnijih fizikalnih i bioloških procesa u akvakulturi povezanih s klimatskim promjenama. U tu svrhu prikupit će se i analizirati dugoročni povijesni trendovi u vodenom stupcu i sedimentu u područjima tipičnim za hrvatskuakvakulturu. Rezultati će se iskoristiti za razvoj modela rasta riba i razumijevanje zdravlja riba i mikrobioloških pokazatelja kao funkcije okolišnih uvjeta. Pomoću razvijenih modela i stečenih znanja predvidjet ćemo učinke najmanje tri scenarijaIPCC klimatskih promjena na proizvodnju i zdravlje riba, koje ćemo analizirati te ćemo za svaki od scenarija specificirati preporuke za prilagodbe proizvodnog procesa. Rezultati će biti objedinjeni u online bazu znanja u obliku koji je dostupan znanstvenicima, proizvođačima u akvakulturi i stvarateljima politika. Projekt, dakle, planira (i) temeljna istraživanja koja rezultiraju novim znanjem, podacima i modelima od interesa za znanstvenike, i (ii) primijenjena istraživanja usmjerena na pripremu akvakulture u Hrvatskoj za promjenu klime. Pokušat će se i uspostaviti suradnja s relevantnim EU projektima u tijeku (npr. ClimeFish) s ciljem postizanja sinergija i priključivanja konzorcija u budućim prijavama na EU projekte.]]></summary_hr><summary_en><![CDATA[Marine finfish aquaculture is an important industry in Croatia with significant growth potential. Since fish are cultured mainly in near-shore cages open to environmental conditions, their growth and well-being, and therefore the aquaculture production, is susceptible to climate change. The effects of the ongoing climate change are becoming increasingly visible, and threaten the viability and development of the aquaculture. AqADAPT will help turn the threats into an opportunity by conducting fundamental research into imminent threats to the aquaculture, and creating a know ledge base for adaptation of the industry. The research will start by focusing on identification of key physical and biological processes in aquaculture affected by climate change. To this end, we will collect and analyze both long-term historical trends, and the seasonal cycles in physical characteristics of the water column and sediments relevant tothe Croatian aquaculture. The results will be used to inform physiologically-based fish growth models, and analysis of threats to fish health and pools of microbiological contamination as functions of environmental conditions. We will use the modelsand knowledge to forecast effects of at least three IPCC climate change scenarios on aquaculture production and fish health. Finally, we will assess the predicted effects, and develop recommendations for adaptation for each of the scenarios. Theresults will be integrated into an on-line know ledge base in a form accessible to scientist, aquaculture producers, and decision-makers. The project therefore plans both (i) fundamental research resulting in new knowledge, data, and models of interest to scientists, and (ii) applied research aimed at preparing aquaculture industry in Croatia for the changing climate. An effort will be made to interact with relevant ongoing EU projects (e.g. ClimeFish), with the goal of achieving synergies and joining the consortium(s) in a future EU funding proposal. ]]></summary_en></project><project>
<id>8081</id><title_hr><![CDATA[Multimodalni prikaz molekularnih zbivanja tijekom oporavka mišjeg mozga nakon ishemijskog oštećenja]]></title_hr><title_en><![CDATA[]]></title_en><user_id>7297</user_id><user_firstLast_name>Srećko Gajović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-1994</code><acronim><![CDATA[RepairStroke]]></acronim><duration>01.07.2019 - 31.12.2023</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>27600</team_members_id><team_members_names><![CDATA[ Doktorand: Sanja Srakočić ]]></team_members_names><keywords_hr><![CDATA[moždani udar, miš, snimanje magnetskom rezonancijom, snimanje bioluminiscencijom, upala]]></keywords_hr><keywords_en><![CDATA[stroke, mouse, magnetic resonanse imaging, bioluminescence imaging, inflammation]]></keywords_en><summary_hr><![CDATA[Moždani udar predstavlja vodeći zdravstveni problem, te postoji potreba razumijevanja mehanizma oporavka i mogućeg liječenja mozga nakon moždanog udara. Ovim projektom pokušava se razjasniti slijed zbivanja tijekom oporavka mozga primjenom multimodalnog prikaza molekularnih zbivanja u mozgu živog miša. To će se postići primjenom niza modaliteta snimanja živih miševa magnetskom rezonancijom, te pretkliničkim optičkim snimanjem bioluminiscencije. Eksperimentalnim zatvaranjem srednje moždane arterije postići će se ishemijsko oštećenje mišjeg mozga. Procesi koji će biti promatrani uključuju upalu (praćenu bioluminiscencijom Tlr2-luc transgeničnog miša), stvaranje novih nastavaka živčanih stanica (praćenu bioluminiscencijom Gap43-luc transgeničnog miša), apoptozu (praćenu zatočenim DEVD-luciferinom), poremećaj i obnovu povezanosti mozga (difuzijskim tenzornim snimanjem magnetskom rezonancijom), te obnovu perfuzije mozga (označavanjem spina u arterijama tijekom snimanja magnetskom rezonancijom) , čijom kombinacijom se očekuje uočiti kritična molekularna i stanična zbivanja koja djeluju neuroprotektivno i obnavljaju mozak. Snimanja živog miša korelirat će se s funkcionalnim i morfološkim analizama mišjeg mozga mikroskopijom i testovima ponašanja životinja. Ovim će se omogućiti definiranje parametara oporavka mozga u mišjem modelu moždanog udara kako bi se pretklinički provjerili mogući terapijski pristupi i omogućila njihova translacija u kliničke pokuse.]]></summary_hr><summary_en><![CDATA[Stroke is the leading health problem, hence a need to understand the mechanism of recovery and possible treatment of the brain dammaged by stroke. This project attempts to clarify the sequence of events during the brain recovery after ischemic lesion by using in vivo multimodal molecular imaging of the mouse brain. This will be achieved through a combination of imaging modalities including magnetic resonance imaging (MRI), and preclinical optical bioluminescence imaging (BLI). Mouse stroke model of the middle cerebral artery occlusion (MCAO) will result in the ischemic brain damage. The processes that will be monitored include inflammation (visualized by bioluminescence of TLR2-luc transgenic mouse), extension of neuronal processes (visualized by bioluminescence of GAP43-luc transgenic mouse), apoptosis (followed by caged DEVD-luciferin), brain connectivity (MR diffusion tensor imaging), and brain perfusion (MRI arterial spin labeling), which combination is expected to describe critical molecular and cellular events that act neuroprotective and regenerate brain. In vivo imaging will be correlated with functional and morphological analysis of the mouse brain using microscopy and behavioral tests. This will allow to define the preclinical parameters of recovery of the brain in a mouse model of stroke to be used to evaluate possible therapeutic approaches and enable their translation into the clinical trials.]]></summary_en></project><project>
<id>8082</id><title_hr><![CDATA[Odgovori na antisocijalne osobnosti u demokratskom društvu ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4121</user_id><user_firstLast_name>Luca Malatesti</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-5165</code><acronim><![CDATA[RAD]]></acronim><duration>18.03.2019 - 17.12.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filozofija, </scie_field_hr><scie_field_en>Philosophy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Filozofski fakultet u Rijeci]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>25808</team_members_id><team_members_names><![CDATA[ Doktorand: Mia Biturajac ]]></team_members_names><keywords_hr><![CDATA[Neuroetika, psihijatrijska etika, antisocijalni poremećaj ličnosti, psihopatija, neuropsihologija, pučka psihologija, liječenje, moralno poboljšanje,]]></keywords_hr><keywords_en><![CDATA[Neuroethics, psychiatric ethics, antisocial personality disorder, psychopathy, treatment, moral enhancement, neuropsychology, folk psychology, ]]></keywords_en><summary_hr><![CDATA[Predloženi istraživački projekt istražit će etička pitanja koja se javljaju pri prevođenju i prenošenju znanstvenih spoznaja o antisocijalnim osobnostima na društvene prakse unutar demokratskog društva. Cilj je povezati ili sučeliti najznačajnije rezultate trenutno dostupnih znanstvenih spoznaja o antisocijalnom ponašanju s normativnim okvirom koji bi trebao potkrijepiti etičke preporuke o liječenju, intervenciji, poboljšanju i prevenciji kriminalaca i drugih osoba s tim poremećajima. U fokusu istraživanja se nalaze dva općenita i hitna teorijska izazova. Jedan je problem povezivanja ili sučeljavanja normativnog pojma osobe i njezinih kognitivnih moći i sposobnosti za odlučivanje sa znanstvenim koncepcijama i spoznajama o tim sposobnostima. Normativni pojam osobe se elaborira u filozofskim i pravnim teorijama kriminalne i moralne odgovornosti koje podrazumijevaju postojanje sposobnosti za racionalno odlučivanje i autonomiju. Drugi je problem artikuliranje normativnog okvira za primjenu na dva međusobno povezana normativna zadatka. Prvo, ovaj okvir mora dati formu opravdanja za pojam normativne osobe koji sam ne smije biti obilježen spornim metafizičkim gledištima već mora biti definiran u terminima koji su prihvatljivi unutar pluralističkog i demokratskog društva. Drugo, normativni okvir mora nas voditi prema praktičnim rješenjima o tome kako reagirati na pojedince s antisocijalnim poremećajima osobnosti, koja mogu biti prihvatljiva svim racionalnim članovima pluralističkog i demokratskog društva. ]]></summary_hr><summary_en><![CDATA[The proposed research project will investigate the ethical issues raised by translating scientific advances in the study of antisocial personalities to the social practices of a democratic society. The aim is to interface the most remarkable results of current science of antisocial behaviour with a normative framework that should underpin ethical recommendations on the treatment, intervention, enhancement and prevention that target offenders and other individuals with these disorders.Two general and pressing theoretical challenges will be at the core of the proposed investigation. One is the problem of interfacing the normative notion of a person and her cognitive and decision-making faculties with scientific conceptions of those faculties. The normative notion of a person is spelled out in philosophical and legal accounts of criminal and moral responsibility that presuppose having capacities for rational decision-making and autonomy. The other is the problem of articulating a normative framework for applying it to two interrelated normative tasks. First, this framework must inform the justification of a notion of the normative person that, being not hostage to metaphysically contestable views, is acceptable within a pluralistic democratic society. Second, it would guide our practical resolutions about how to respond to individuals with antisocial personalities that is viable in a pluralistic democratic society.]]></summary_en></project><project>
<id>8083</id><title_hr><![CDATA[Bilinogojstvom do sekundarnih biljnih metabolita: primjena mineralnih hraniva i elicitora za povećanje koncentracije fenola u listu masline]]></title_hr><title_en><![CDATA[]]></title_en><user_id>12403</user_id><user_firstLast_name>Igor Pasković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-1841</code><acronim><![CDATA[PhytoFarmOL]]></acronim><duration>20.12.2018 - 18.04.2023</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Institut za poljoprivredu i turizam]]></institution_hr><institution_en><![CDATA[Institute of Agriculture and Tourism in Poreč]]></institution_en><team_members_id>25433</team_members_id><team_members_names><![CDATA[ Doktorand: Kristina Grozić ]]></team_members_names><keywords_hr><![CDATA[ishrana bilja, list masline, oleuropein, paunovo oko, oralno zdravlje]]></keywords_hr><keywords_en><![CDATA[plant nutrition, olive leaf, oleuropein, olive leaf spot, oral health]]></keywords_en><summary_hr><![CDATA[Fenolni spojevi oleuropein i hidroksitirosol smatraju se glavnim aktivnim spojevima lista masline za koje je dokazano antikancerogeno, protuupalno i antimikrobno djelovanje. Oleuropein i hidroksitirosol, ali i ostali fenoli, imaju specifičnu ulogu u zaštiti bilja i povećanju otpornosti na fitopatogene gljive što može biti od presudne važnosti za održivi uzgoj maslina općenito. Fenoli i polifenoli su sveprisutni spojevi u biljkama koji igraju važnu ulogu u obrambenom mehanizmu biljke domaćina u odnosu na filamentozne gljive. Važnost fenola, pored povećanja otpornosti biljke na patogene, očituje se i u proizvodnji funkcionalne hrane i nutraceutika te lijekova na prirodnoj bazi za liječenje oralnih bolesti. Potreba za pronalaskom novih terapijskih postupaka u liječenju patoloških stanja usne šupljine dovela je do povećanog interesa za upotrebu prirodnih supstrata.Dokazano je da poljoprivredna praksa može povećati sadržaj fenola u listu masline. Samo je nekoliko istraživanja do sada bilo usmjereno na proučavanje utjecaja mineralne ishrane na sastav fenola u listu masline. U ovom projektu planira se provesti cijeli niz eksperimenata kako bi se utvrdio utjecaj određenih mineralnih hraniva (N, Ca, Mg, Mn, Zn, Cu i B) i elicitora (fosfit i kalijev silikat) na sastav fenola u listu masline kod različitih sorata. Također ocijenit će se i utjecaj prethodnog odabranog mineralnog hraniva ili elicitora, koji se pokaže kao najučinkovitiji u povećanju razine fenola, na razvoj bolesti paunovo oko koje uzrokuje fitopatogena gljiva Venturia oleaginea (sin. Spilocaea oleaginea). Razvoj bolesti pratit će se na tretiranim maslinama u polju ili kontroliranim uvjetima u plasteniku. Učinak najboljeg tretmana bit će ispitan kroz kvalitetu maslinovog ulja na sorti Leccino uzgajanoj na različitim terroirima. U okviru ovog projekta također se planiraju provesti predklinička i klinička istraživanja utjecaja ekstrakta lista masline na kandidijazu usne šupljine.]]></summary_hr><summary_en><![CDATA[Oleuropein and hydroxytyrosol are considered the main active olive compounds and their health benefits thought their anti-carcinogenic, anti-inflammatory, and antimicrobial proprieties has been proven. Nevertheless, oleuropein and hydroxytyrosol as well as total phenols, have specific role plant protection and resistance against fungal pathogens which may be of crucial importance for olive sustainable growing. It has been noticed that phenolic and polyphenolic compounds, as pre-formed antibiotic compounds, are ubiquitous in plants and play an important role in host plant’s pre-existing chemical defences against filamentous fungi. The phenolics in olive leaves, beside upgraded resistance to fungal pathogens, may have potential in the production of functional food and nutraceuticals. They could be easily used as oral remedies in the treatment of stomatognatic pathological conditions, where the need of finding new therapeutic procedures has led to increased interest in the use of natural substrates. There are evidence that agricultural practices can increase phenolics in olive leaves. Only a few studies have been focused on studying the effects of olive mineral nutrition on the olive leaves phenolic profile. In this project, series of experiments are planned to be conducted in order to determine the effect of selected mineral elements (N, Ca, Mg, Mn, Zn, Cu, and B) and elicitors (phosphite and potassium silicate) on leaf phenolic profile of olive cultivars. The effect of previously selected mineral/elicitor treatment as the best phenolic enhancer, on the development of olive leaf spot (Venturia oleaginea - syn. Spilocaea oleaginea), will be tested under greenhouse and field conditions. The impact of best phenolic enhancer will be tested thought quality of olive oil on Leccino cultivar grown at different terroirs. The preclinical and clinical studies investigating the effect of olive leaf extract on oral cavity candidiasis will be conducted during this project as well.]]></summary_en></project><project>
<id>8084</id><title_hr><![CDATA[Karakterizacija hrskavice acetabuluma i femura u odraslih bolesnika s razvojnim poremećajem kuka]]></title_hr><title_en><![CDATA[]]></title_en><user_id>7499</user_id><user_firstLast_name>Domagoj  Delimar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-5584</code><acronim><![CDATA[HIPoCART]]></acronim><duration>06.05.2019 - 05.11.2023</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Clinical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>28649</team_members_id><team_members_names><![CDATA[ Doktorand: Tea Duvančić ]]></team_members_names><keywords_hr><![CDATA[Hrskavica, Razvojni poremećaj kuka, Multimodalna karakterizacija, Histologija, Ortopedija]]></keywords_hr><keywords_en><![CDATA[Cartilage, Developmental dysplasia of the hip, Multimodal characterisation, Histology, Orthopaedics]]></keywords_en><summary_hr><![CDATA[Razvojni poremećaj kuka u odrasloj dobi (RPKOD) predstavlja jedan od najčešćih uzroka sekundarne koksartroze. Ovim projektom razjasniti će se po prvi put histološka građa hrskavice glave femura i acetabuluma koja u visokim stupnjevima RPKOD (Crowe 3. i 4. stupanj) nije u kontaktu s kontralateralnim zglobnim tijelom. Nepostojanje međusobnog kontakta zglobnih tijela tijekom razvoja čini prirodni eksperiment koji je prisutan u bolesnika s visokim stupnjem RPKOD, budući da se hijalina hrskavica kod tih bolesnika razvija bez prisutnosti mehaničkog opterećenja. Karakterizacijom građe hrskavice potvrditi će se i/ili redefinirati i modificirati općeprihvaćena paradigma koja podrazumijeva nužno postojanje mehaničke sile kao neophodnog preduvjeta za uredan razvoj hijaline hrskavice zgloba kuka. Uzorci tkiva hrskavice te subhondralne kosti acetabuluma, neoacetabuluma i femura će se prikupiti tijekom ugradnje totalne endoproteze (TEP) kuka u bolesnika s razvijenom sekundarnom koksartrozom zbog RPKOD (Crowe 3 i 4). Dobiveni rezultati usporediti će se s rezultatima analize uzoraka hrskavice bolesnika s primarnom koksartrozom, te bolesnika s očuvanom hrskavicom koji podliježu operativnom zahvatu ugradnje TEP kuka zbog prijeloma u području kuka (kontrolne skupine). Provesti će se snimanje strukture uzoraka hrskavice i subhondralne kosti magnetskom rezonancom uređajem od 7T te mikro-kompjuteriziranom tomografijom. Potom će se provesti karakterizacija mikroskopske građe hrskavice primjenom niza različitih histoloških obilježavanja (klasična i specifična histološka bojenja, imunohistokemijska obilježavanja pojedinih podvrsta kolagena i sl.), uz adekvatnu analizu slika. Rezultati istraživanja uvelike će pridonijeti općem razumijevanju razvoja hijaline hrskavice i subhondralne kosti, a posebice utjecaja mehaničkog stimulusa u istome. Očekuje se značajan utjecaj dobivenih rezultata na područje regenerativne medicine kao i translacija dobivenih rezultata na kliničku praksu.]]></summary_hr><summary_en><![CDATA[Developmental dysplasia of the hip (DDH) is one of the most common causes of secondary hip osteoarthritis in adult population. In higher grades of DDH in adult age (Crowe grade 3 or 4), in more than 75% of the cartilage surface there is no contact between acetabulum and femur. In this project, cartilage and subchondral bone structure on both articular surfaces will be characterized for the first time, using different approaches. Lack of contact between these cartilage surfaces represents a natural experiment, since the development of such cartilage does not include mechanical load. Characterization of the articular cartilage structure will either confirm or redefine and modify the currently accepted paradigm that mechanical load is crucial for normal development of joint cartilage. Tissue samples of acetabulum, neoacetabulum and femoral head, including cartilage and underlying subchondral bone will be harvested during total hip arthroplasty (THA) in patients with secondary hip osteoarthritis caused by DDH (Crowe 3 or 4). Results will be compared to the results of samples harvested in patients suffering from primary hip osteoarthritis, or patients with femoral neck fracture that require THA, but have healthy cartilage (control group). Samples will be scanned using 7T micro-magnetic resonance imaging as well as micro computed tomography. Afterwards, samples will be microscopically analysed using specific histological staining protocols and immunohistochemical labelling of e.g. various collagen subtypes etc. Results of this project will merely influence general understanding of cartilage and subchondral bone development. These results will determine whether mechanical load plays crucial role for proper cartilage formation. Results of this project will definitely have impact on the field of regenerative medicine, and translation of these results to clinical practice is expected as well.]]></summary_en></project><project>
<id>8085</id><title_hr><![CDATA[Fizičko modeliranje ponašanja konstrukcija za sanaciju klizišta u uvjetima statičkih i seizmičkih djelovanja]]></title_hr><title_en><![CDATA[]]></title_en><user_id>20171</user_id><user_firstLast_name>Željko Arbanas</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-9004</code><acronim><![CDATA[ModLandRemSS]]></acronim><duration>01.05.2019 - 01.03.2023</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Građevinarstvo, </scie_field_hr><scie_field_en>Civil engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Građevinski fakultet u Rijeci]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Civil Engineering]]></institution_en><team_members_id>28704</team_members_id><team_members_names><![CDATA[ Doktorand: Sara Pajalić ]]></team_members_names><keywords_hr><![CDATA[klizište, fizički model, modeliranje, sanacija, konstrukcija, monitoring]]></keywords_hr><keywords_en><![CDATA[landslide, physical model, modelling, remediation, structure, monitoring]]></keywords_en><summary_hr><![CDATA[Fizičko modeliranje klizišta na temelju analiza ponašanja umanjenih modela započeto je krajem 1980-tih kad je istraživano ponašanje tokova tla i fluidifikacije kliznog materijala u umanjenom fizičkom modelu (također poznatom pod nazivom flume ili flume test). Glavni zadatak fizičkog modeliranja klizišta u zadnjih 25 godina bilo je istraživanje pokretanja, kretanja i akumulacije brzih klizišta nalik tečenju uzrokovanih infiltracijom vode u kosinu. Brojni modeli klizišta i istraživanja mogu se podijeliti u dvije glavne grupe vezane na osnovne pokretače klizišta: oborine i potrese. Postojeće studije ponašanja sanacijskih konstrukcija na klizištima u fizičkim modelima vrlo su rijetke. Predloženi Projekt uključiti će istraživanja ponašanja različitih konstrukcije primijenjenih za sanacije klizišta u fizičkim modelima umanjenih klizišta u statičkim i dinamičkim uvjetima gdje statički uvjeti pretpostavljaju uvjete klizišta pokrenutih oborinama, a dinamički uvjeti uvjete klizišta izazvanih potresima. Promatranje gibanja u fizičkom modelu klizišta provesti će se mrežom senzora za mjerenje pomaka, pritisaka, sila i pornih pritisaka i inovativnom fotogrametrijskom opremom koja uključuje terestrički laserski skener i infracrvenu kameru. Umanjene sanacijske konstrukcije izraditi će se 3D printerom što će omogućiti precizne umanjene elemente konstrukcija. Izmjereni parametra iz fizičkog modela biti će uključeni u 3D numeričke simulacije. Rezultati iz oba modela omogućiti će bolje razumijevanje ponašanja konstrukcija za sanaciju klizišta. Metode analiza stabilnosti koje se koriste za projekte sanacije klizišta u inženjerskoj praksi još uvijek su grube i rezultiraju odabirom konzervativnih sanacijskih konstrukcija. Zbog tog razloga, rezultati istraživanja mogli bi predstavljati osnovu za nove pristupe racionalnog projektiranja sanacijskih konstrukcija za klizišta u inženjerskoj praksi.]]></summary_hr><summary_en><![CDATA[Physical modelling of landslide using scaled landslide models behaviour was established at the end of 1980s when in a scaled physical model (flume or flume test) behaviour of flowslide and liquefaction of sliding material were investigated. The main task of landslide physical modelling in last 25 years was research of initiation, motion and accumulation of fast flow like slides caused by infiltration of surface water in a slope. The numerous established landslide physical models and researches can be divided in two main groups related to landslide main triggering factors: rainfall and earthquakes. The existing studies of landslide remedial construction behaviour using physical modelling are very rare. The proposed Project will encompass researches of behaviour of different construction applied for landslide remediation in physical models of scaled landslides in static and dynamic conditions where static conditions imply conditions for rainfall triggered landslides and dynamic conditions imply conditions for earthquake induced landslides. Observations of landslide movements in a physical model will be carried out by sensor network for measuring displacements, pressures, forces and pore pressures and innovative photogrammetric equipment including terrestrial laser scanner and infrared camera. Scaled remedial constructions will be constructed by 3D printer that will enable precise scaled construction elements. The measured parameters from physical model will be included in 3D numerical simulation. The results of both physical and numerical modelling will enable better understanding of landslide remedial construction behaviour. Methods of stability analysis used for landslide remediation design in engineering practice are still very rough and result with selection of conservative remedial constructions. For that reason, research results would represent the base for new approaches to the rational landslide remedial construction designing in engineering practice.]]></summary_en></project><project>
<id>8086</id><title_hr><![CDATA[Genomske i epigenomske promjene u auto- i alopoliploidima na modelu dalmatinskog buhača, ljutike i anemona]]></title_hr><title_en><![CDATA[]]></title_en><user_id>19875</user_id><user_firstLast_name>Jasna Puizina</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-1792</code><acronim><![CDATA[AutoAloPol]]></acronim><duration></duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu]]></institution_hr><institution_en><![CDATA[University of Split]]></institution_en><team_members_id>29194</team_members_id><team_members_names><![CDATA[ Doktorand: Mila Vuković ]]></team_members_names><keywords_hr><![CDATA[autopoliploidija, alopoliploidija, genomika, epigenomika, evolucija biljnog genoma]]></keywords_hr><keywords_en><![CDATA[autopolyploidy, allopolyploidy, genomic, epigenomic, plant genome evolution]]></keywords_en><summary_hr><![CDATA[Poliploidija/udvostručavanje genoma glavni je pokretački mehanizam specijacije i bioraznolikosti biljaka koji dovodi do stvaranja novih genetičkih varijanti, pokreće evoluciju, povećava genetičku raznolikost organizama te ima veliku ulogu u domestikaciji biljaka. Iako su rađena brojna istraživanja još uvijek se malo zna o promjenama koje se događaju na razini genoma nakon poliploidizacije i hibridizacije. Auto- i alopoliploidija dovodi do nestabilnosti i reorganizacije genoma. Nepravilna segregacija kromosoma u mejozi glavni je problem za formiranje funkcionalnih gameta i uspješnog spolnog razmnožavanja novosintetiziranih autopoliploida. Evolucijski stari autopoliploidi razvili su mehanizme koji su s vremenom osigurali pravilnu segregaciju kromosoma. Točan mehanizam prelaska iz nestabilnog u stabilno stanje genoma nakon poliploidizacije još je nerazjašnjeno. Ovim projektom istražit će se mejotski procesi koji dovode do pravilne segregacije kromosoma i ekspresija gena uključenih u sparivanje kromosoma/homolognu rekombinaciju u autotetraploidu dalmatinskog buhača (T. cinerariifolium). Stabilizacija mejoze kroz mali broj generacija važna je za komercijalnu proizvodnju autotetraploida. Genomi alopoliploidnih vrsta izuzetno su dinamični zbog interakcija između subgenoma koje dovode do homogenizacije alopoliploida. Homogenizacija se odvija kroz genomske rearanžmane (inverzije, translokacije, trasnpozicije) i delecije dijelova genoma u koje su najčešće uključene ponavljajuće DNA kao i promjene u metilaciji DNA. Ovim projektom žele se na razini genoma i epigenoma utvrditi koji mehanizmi i u kojoj mjeri su uključeni u reorganizaciju genoma sterilne alotriploidne ljutike (A. × cornutum), fertilne alotetraploidne vrste A. multifida i aloheksaploidne A. baldensis. Istraživanja predložena ovim projektom pružit će bolji uvid u promjene na razini genoma i epigenoma u vrstama važnim za ljudsku prehranu, ekološku poljoprivredu i proizvodnju novih hortikulturnih varijanti.]]></summary_hr><summary_en><![CDATA[Polyploidy/genome duplication is the main mechanism of speciation and biodiversity in plants, drives evolution, increases genetic diversity and organism complexity, and plays an important role in domestication of plants. Although numerous studies have been conducted so far, we still don’t know enough about the genomic changes that are taking place after polyploidization and hybridization. Auto- and allopolyploidy lead to genome instability and reorganization. Improper chromosome segregation in meiosis is the main problem for functional gamete formation and successful sexual reproduction in neo-autopolyploids. Evolutionary old autopolyploids have developed mechanisms that lead to proper chromosome segregation but the exact mechanism of transition from unstable to stable genome condition after polyploidization is not fully understood. This project will study meiotic processes that lead to the proper chromosome segregation as well as gene expression involved in chromosome pairing/homologous recombination in autotetraploid pyrethrum (T. cinerariifolium). Stabilization of meiosis through a few generations is important for commercial production of autotetraploids. Genomes of allopolyploid species are extremely dynamic in terms of their subgenome interactions that lead to their homogenization. Homogenization is carried out through genomic rearrangements (inversions, translocations, transposition) and partial genome (rich in repetitive DNA) deletions as well as changes in DNA methylation. With this project we want to determine the mechanisms at the genome and the epigenome level which are involved in reorganization of subgenomes in sterile allotriploid shallot (A. x cornuntum) and fertile allotetraploid A. multifida and allohexaploid A. baldensis. The research proposed in this project will provide a better insight into changes at the genomic and epigenomic level in species important for human consumption, organic farming and the production of new horticultural varieties.]]></summary_en></project><project>
<id>8087</id><title_hr><![CDATA[Relevantnost hermeneutičkog prosuđivanja]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4842</user_id><user_firstLast_name>Jure Zovko</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-3964</code><acronim><![CDATA[RHJ]]></acronim><duration>01.09.2019 - 31.08.2023</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filozofija, </scie_field_hr><scie_field_en>Philosophy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zadru]]></institution_hr><institution_en><![CDATA[University of Zadar]]></institution_en><team_members_id>865276</team_members_id><team_members_names><![CDATA[ Doktorand: Maja Ferenec Kuća ]]></team_members_names><keywords_hr><![CDATA[Hermeneutika, prosudba, interpretacija, razumijevanje, um, humanistika]]></keywords_hr><keywords_en><![CDATA[Hermeneutics, Judgment, Interpretation, Understanding, Reason, Humanities]]></keywords_en><summary_hr><![CDATA[Primarna intencija ovog planiranoga istraživanja jest pokazati da je hermeneutička prosudba integralni dio teorije razumijevanja i interpretacije. Tradicionalno, strogo metodološko razlikovanje između prirodnih i humanističkih znanosti posve je neodrživo (W. Dilthey, M. Heidegger, Charles Percy Snow, Hans-Georg Gadamer). Razumijevanje nije samo obilježje humanističkih znanosti, nego je također krucijalni segment prirodnih i tehničkih znanosti. Svrha prijavljenoga istraživačkoga projektnoga prijedloga jest razmotriti hermeneutičku metodologiju u kontekstu suvremenih promjena paradigma i pragmatičnoga zaokreta s posebnim osvrtom na filozofiju. Primarno ćemo se usredotočiti na relevantnost prosuđivanja u procesu razumijevanja i na hermeneutičku interpretaciju te pokazati da postupak razumijevanja ne podrazumijeva samo rekonstrukciju stvaralaštva duha, nego također njegovu prosudbu, vrjednovanje i sustavnu analizu.Uspješno kultiviranje sposobnosti prosuđivanja podrazumijeva stručnu kompetentnost i sposobnost refleksivne analize svega onoga što predstavlja stvaralaštvo ljudskoga duha, kulturnu baštinu. Na primjeru analize filozofskih djela kao što su Kantova Kritika moći suđenja, Wittgensteinovi kasni spisi,  te suvremene recepcije Hegelove praktične filozofije (Pippin, Brandom, McDowell, Honneth) razmotrit ćemo u kojoj je mjeri  kultiviranje duha preduvjet za uspješnu interpretaciju i prosudbu stvaralačkoga djela, kao i za kritičko suočavanje s postojećim formama kulturnoga i društvenoga životnoga svijeta te svega onoga što predstavlja interpretandum. U tom kontekstu kultiviranja ljudskoga uma i prosudbe razmotrit ćemo zahtjevnu ulogu i zadaću obrazovanja. ]]></summary_hr><summary_en><![CDATA[The proposal’s primary intention is to show that hermeneutical judgment is an integral part of the theory of understanding and interpretation. The traditional strict methodological distinction between the natural sciences and the humanities (Dilthey, Heidegger, Snow, Gadamer) is no longer acceptable.  Understanding is not only a feature of the humanities, but also a crucial segment of the natural sciences and engineering.Our aim is to examine hermeneutical methodology in the context of changing paradigms and the pragmatic turn, in particular with regard to philosophy. Primarily, we will focus on the relevance of judgment in the process of understanding, interpretation and explanation. In this context, we will show that the process of understanding presupposes not only a reconstruction of the products of human intelligence and creativity, but also their judgment, evaluation, and systematic analysis. The successful cultivation of judgement requires informed competence and the capacity for reflective analysis of higher-level manifestations of the human spirit which form the content of our cultural heritage and whose interpretation forms the specific task of the humanities. On the basis of analysis of works such as Kant&#39;s Critique of Judgment, Wittgenstein’s late works, and contemporary interpretation of Hegel’s practical philosophy (Pippin, Brandom, McDowell, Honneth) the project will investigate to what extent cultivation of mind is a precondition for successful interpretation and judgment of, as well as for critical confrontation with, forms of cultural and social production. We will consider to what extent understanding in the humanities presupposes the reflective capacity of judgment and in what manner study of content and topics from the humanities contributes to cultivation and sharpening of the ability to judge, evaluate and comprehend the intepretandum. In the context of the analysis of judgment we will consider the role and task of education.]]></summary_en></project><project>
<id>8088</id><title_hr><![CDATA[NERO- Neurokirurški robot]]></title_hr><title_en><![CDATA[]]></title_en><user_id>7302</user_id><user_firstLast_name>Bojan Jerbić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-2312</code><acronim><![CDATA[]]></acronim><duration>11.03.2019 - 11.03.2023</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, </scie_field_hr><scie_field_en>Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>25713</team_members_id><team_members_names><![CDATA[ Doktorand: Ivan Župančić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>8089</id><title_hr><![CDATA[Novi pristup razvoju cjepiva za kongenitalnu citomegalovirusnu infekciju]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5273</user_id><user_firstLast_name>Irena Slavuljica</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-7189</code><acronim><![CDATA[VaccongCMV]]></acronim><duration>09.09.2019 - 24.09.2025</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Medicine]]></institution_en><team_members_id>864864</team_members_id><team_members_names><![CDATA[ Doktorand: Lydia Gaćina ]]></team_members_names><keywords_hr><![CDATA[Citomegalovirus, kongenitalna CNS infekcija, receptor NKG2D, cjepivo, CD8 T stanice]]></keywords_hr><keywords_en><![CDATA[Cytomegalovirus, congenital CNS infection, NKG2D receptor, vaccine, CD8 T cells]]></keywords_en><summary_hr><![CDATA[Humani citomegalovirus (HCMV) je najčešći virusni uzročnik kongenitalne infekcije te često uzrokuje dugotrajne neurološke posljedice. Razvoj cjepiva za HCMV je prioritet moderne medicine. Citomegalovirusi (CMV) su specifični za vrstu te je infekcija miševa mišjim CMV-om (MCMV) često korišteni model HCMV-infekcije. NKG2D je snažni aktivacijski receptor stanica NK. Važnost NKG2D u virusnoj kontroli ilustrira činjenica da su CMV-i razvili brojne mehanizme za izbjegavanje kontrole posredovane NKG2D. Mi smo karakterizirali proteine MCMV-a m145, m152 i m155 koji negativno reguliraju ispoljavanje NKG2D-liganada MULT1, RAE-1 and H60. Budući je NKG2D također i kostimulacijski receptor CD8 limfocita T, insercija liganda koji prepoznaje ovaj aktivacijski receptor u genom CMV-a može biti korištena kao novi pristup u dizajniranju cjepiva koja su usmjerena indukciji odgovora CD8 limfocita T. Stoga smo konstruirali rekombinantni MCMV u kojem je NKG2D ligand RAE-1g ubačen u genom MCMV-a na mjesto njegovog inhibitora m152 (RAE-1gMCMV) (Slavuljica i sur. JCI, 2010). RAE-1gMCMV je jako atenuiran in vivo, ali u isto vrijeme potiče snažan i dugotrajan imuni odgovor. U ovom projektu planiramo koristiti rekombinante MCMV koji ispoljavaju druga dva NKG2D liganda, MULT1 i H60, te testirati mogu li rekombinantni CMV koji ispoljavaju različite NKG2D ligande biti korišteni kao cjepivo protiv kongenitalne infekcije CMV-om. Odrediti ćemo imunogeničnost i protektivni kapacitet ovih rekombinantnih virusa. Poseban naglasak ćemo staviti na sigurnosti njihove primjene kao cjepiva. Stoga ćemo na modelu CMV infekcije novookoćenih miševa proučavati razvojne i upalne promjene u mozgu. Konačni cilj ovog projekta je dizajnirati rekombinantno CMV cjepivo koje je sigurno i jako atenuirano i u imunološki nezrelom domaćinu, a u isto vrijeme inducira protektivan i dugotrajan imuni odgovor.    ]]></summary_hr><summary_en><![CDATA[Human cytomegalovirus (HCMV) is the most common viral cause of congenital infections and frequently leads to long-term neurologic sequelae. Development of HCMV vaccine is a high priority of modern medicine. Cytomegaloviruses (CMVs) are species specific and infection of mice with the murine CMV (MCMV) is frequently used model for HCMV infection. NKG2D is a potent activating receptor on NK cells. The importance of NKG2D in virus control is illustrated by the fact that CMVs developed numerous mechanisms to evade NKG2D-mediated control. We have characterize MCMV proteins m145, m152 and m155 involved in the downmodulation of NKG2D ligands MULT1, RAE-1 and H60, respectively. Since NKG2D also acts as a co-stimulatory receptor on CD8 T cells, the insertion of a ligand recognized by this activating receptor into the CMV genome could be used as a new approach in designing vaccines that are directed to the induction of CD8 T cell response. Therefore we constructed recombinant MCMV in which NKG2D ligand RAE-1g was inserted into the MCMV genome in place of its inhibitor m152 (RAE-1gMCMV) (Slavuljica et al. JCI, 2010). RAE-1gMCMV is highly attenuated in vivo but at the same time induces potent and long-lasting immune response. In frame of this project we plan to use recombinant MCMV expressing two other NKG2D ligands, MULT1 and H60, and test whether recombinant CMV expressing various NKG2D ligands could be used as vaccine against congenital CMV infection. Immunogenicity and protective capacity of these recombinant viruses will be determined. Special emphasis will be given on safety of their use as vaccines. To that aim in newborn model of CMV infection developmental changes and inflammation in brain will be studied. The ultimate goal of this project is to design recombinant CMV vaccine which is safe and strongly attenuated even in immunologically immature hosts, but at the same time able to induce protective and long-lasting immune response.]]></summary_en></project><project>
<id>8090</id><title_hr><![CDATA[Sinkroni reluktantni generatori za mikro hidroelektrane]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1528</user_id><user_firstLast_name>Stjepan Stipetić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-8572</code><acronim><![CDATA[HYDREL]]></acronim><duration>12.06.2019 - 12.03.2023</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>28672</team_members_id><team_members_names><![CDATA[ Doktorand: Marijan Martinović ]]></team_members_names><keywords_hr><![CDATA[sinkroni generatori, reluktantni strojevi, mikro hidroelektrane, optimizacija, energetski pretvarači]]></keywords_hr><keywords_en><![CDATA[synchronous generators, reluctance machines, micro hydropower plants, optimisation, power electronic converter]]></keywords_en><summary_hr><![CDATA[Učinkovita potrošnja energije i povećana upotreba energije iz obnovljivih izvora su promovirane strateškim planovima Europske unije i Hrvatske. Mikro, mini i male hidroelektrane imaju značajan neiskorišteni potencijal i prednost pred energijom vjetra i sunčevom energijom u stabilnijoj i predvidivoj proizvodnji. Vodna turbina i električni generator su ključni elementi takvih sustava koji trebaju imati nisku cijenu, visoku učinkovitost i pouzdanost. Novi sustavi za pretvorbu energije su temeljeni na turbini promjenjive brzine vrtnje i na generatoru spojenom na energetski pretvarač čime se ostvaruje fleksibilan sustav za upravljanje radnom i jalovom snagom. Topologije generatora, koje nude visoku učinkovitost, temeljene su na stalnim magnetima s elementima rijetkih zemalja koji imaju visoku i nestabilnu cijenu na tržištu i čija proizvodnja ima iznimno negativan učinak na okoliš. Alternativa strojevima sa stalnim magnetima su sinkroni reluktantni strojevi, jednostavnog robusnog dizajna bez magneta, visoke učinkovitosti i niske cijene.Projekt HYDREL istražuje mogućnosti korištenja reluktantnih strojeva kao generatora u mikro hidroelektranama. Istraživanja i inovacije na projektu HYDREL su usredotočeni na sljedeće ciljeve: (i) istraživanje koncepta proizvodnje energije u mikro hidroelektranama inovativnim simulacijskim sustavom, (ii) istraživanje inovativnih i optimalnih oblika rotorskih barijera uz projektiranje i izradu prototipa reluktantnih generatora visoke učinkovitosti, (iii) projektiranje i izradu prototipa energetskog pretvarača s optimiranim filterskim komponentama, (iv) istraživanje inovativnog upravljačkog algoritma za energetski učinkovito upravljanje uz identifikaciju i adaptaciju parametara generatora. Razvijeni koncepti će biti potvrđeni simulacijskim modelima i eksperimentalno na laboratorijskom postavu dva mehanički spojena prototipna stroja, koji predstavljaju turbinu i generator, a spojeni su na mrežu preko prototipa energetskog pretvarača.]]></summary_hr><summary_en><![CDATA[Efficient energy consumption and the increased use of energy from renewable sources are promoted by strategic plans of the European Union and Croatia. Micro, mini and small hydropower plants have a significant unused potential and an advantage over wind and solar in more stable and predictable energy production. Water turbine and electrical generator are the key elements of such systems which need to have low cost, high efficiency, and reliability. Novel systems for energy conversion are based on the variable speed turbine and on the synchronous generator coupled with the power converter thus forming a flexible system capable of active and reactive power control. The most efficient generator topologies are based on rare-earth permanent magnets which have high and unstable price and whose manufacturing has an extremely negative environmental impact. An alternative to permanent magnet machines are the synchronous reluctance machines, which have simple robust design without magnets, high efficiency, and low cost.HYDREL project explores the capability of exploiting synchronous reluctance machine as a main generating unit in a micro hydropower plant. As a step forward in research and innovation, the focus of HYDREL is set on the following objectives: (i) research on power generation concept of micro hydropower plant through innovative simulation environment, (ii) research on innovative and optimal rotor flux barrier shapes along with design and prototyping of two high-efficiency synchronous reluctance generators, (iii) design and prototyping of power electronic converter with optimized filter components, (iv) research on innovative energy-efficient control algorithm with identification and adaptation of generator parameters. The developed system will be experimentally verified on the test rig consisting of two coupled prototyped machines representing turbine-generator system connected to the electrical grid through a prototyped power electronic converter.]]></summary_en></project><project>
<id>8091</id><title_hr><![CDATA[Hlađenje atoma frekventnim češljem]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5029</user_id><user_firstLast_name>Damir Aumiler</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-6984</code><acronim><![CDATA[CoolComb]]></acronim><duration>16.12.2019 - 15.12.2024</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut za fiziku]]></institution_hr><institution_en><![CDATA[Institute of Physics in Zagreb]]></institution_en><team_members_id>28963</team_members_id><team_members_names><![CDATA[ Doktorand: Vjekoslav Vulić ]]></team_members_names><keywords_hr><![CDATA[lasersko hlađenje, hladni atomi, optički frekventni češalj, rubidij, magneto-optička stupica]]></keywords_hr><keywords_en><![CDATA[laser cooling, cold atoms, optical frequency comb, rubidium, magneto-optical trap]]></keywords_en><summary_hr><![CDATA[Uvođenje laserskog hlađenja u atomsku i molekulsku fiziku prije tri desetljeća započelo je revoluciju koja nastavlja redefinirati krajolik eksperimenata koji nam pomažu bolje razumijeti kvantni svijet. Korištenje uskopojasnih kontinuiranih lasera za kontrolu temperature atoma evoluiralo je tijekom godina te postiglo puno šire područje primjene nego što je prvobitno bilo predviđeno, brzo pomičući granice znanstvenog razvoja kroz impresivne pothvate u području ultrahladnih atoma. Ipak, unatoč značajnim napretcima, preostaju važne praznine unutar područja, a jedna od najizraženijih je naša nemogućnost da laserski hladimo i zarobljavamo vodik, (gotovo sve) molekule te najrasprostranjenije atome organske kemije: ugljik, kisik i dušik.Cilj ovog projekta je stvoriti alate koji će nam omogućiti širenje primjene laserskog hlađenja na raznolike vrste atoma i molekula. Konkretno, koristit ćemo optički frekventni češalj za izravno lasersko hlađenje i zarobljavanje atoma rubidija (Rb) te demonstrirati istodobno hlađenje dva Rb izotopa. Kako bi postigli taj cilj, okupili smo iskusan tim istraživača - stručnjake za lasersku fiziku, hladne atome, spektroskopiju frekventnim češljem te teorijsko modeliranje međudjelovanja lasera i atoma - koji će (i) teorijski modelirati radijativnu silu na atome uzrokovanu frekventnim češljem i odrediti optimalne parametre češlja za hlađenje, (ii) dizajnirati i izgraditi novi pikosekundni Ti:safir laser sa spregnutim modovima pumpan plavim diodama, (iii) stabilizirati i postići kontrolu nad spektrom frekventnog češlja lasera te (iv) primijeniti frekventni češalj za izravno hlađenje i zarobljavanje Rb atoma i istodobno hlađenje dvije vrste atoma.Naša uspješna demonstracija potvrdit će frekventni češalj kao novi alat za lasersko hlađenje šireg raspona molekula i atoma koje do sada nije bilo moguće hladiti, omogučujući tako napredak u područjima kao što su kontrolirana kemija, astrofizika, precizna mjerenja te kvantne informacije i simulacije.]]></summary_hr><summary_en><![CDATA[The introduction of laser cooling to atomic and molecular physics three decades ago started a revolution that continues to redefine the landscape of feasible experiments which help us better understand the quantum world. The use of narrow-band continuous-wave lasers to control the motional temperature of atoms has evolved over the years to have much broader applications than originally anticipated, rapidly pushing forward the frontiers of scientific development through impressive efforts in the field of ultracold atoms. Yet despite these substantial advances, there remain important gaps in the field, one of the most conspicuous being our inability to laser cool and trap hydrogen, (almost any) molecules, or the most prevalent atoms in organic chemistry: carbon, oxygen, and nitrogen.The aim of this project is to create the tools that will allow us to extend laser cooling to more diverse species of atoms and molecules. Specifically, we will use an optical frequency comb for direct laser cooling and trapping of rubidium (Rb) atoms, and demonstrate simultaneous comb cooling of two Rb isotopes. To achieve this goal, we have gathered an experienced team of researchers – experts in laser physics, cold atoms, frequency comb spectroscopy, and theoretical modeling of laser-atom interactions – who will (i) theoretically model the comb-induced radiative force on atoms and define optimal comb parameters for cooling, (ii) design and build a novel blue-diode-pumped Ti:sapphire picosecond mode-locked laser, (iii) stabilize and gain control over its frequency comb spectrum, and (iv) apply the comb for direct cooling and trapping of Rb atoms and simultaneous dual-species cooling.Our successful demonstration will validate the frequency comb as a new tool for laser cooling a broader range of molecules and so far un-coolable species thus allowing breakthroughs in fields as diverse as controlled chemistry, astrophysics, precision measurements, and quantum information and simulation.]]></summary_en></project><project>
<id>8092</id><title_hr><![CDATA[Preuređivanje memorije: Manipuliranje T-staničnom memorijom u svrhu unapređenja učinkovitosti cjepiva]]></title_hr><title_en><![CDATA[]]></title_en><user_id>19051</user_id><user_firstLast_name>Felix Wensveen</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-2620</code><acronim><![CDATA[T-MEMORY]]></acronim><duration>01.03.2019 - 28.09.2023</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Medicine]]></institution_en><team_members_id>25630</team_members_id><team_members_names><![CDATA[ Doktorand: Mia Krapić ]]></team_members_names><keywords_hr><![CDATA[T Stanična memorija, infekcija, rak, Eomes, T stanični receptor]]></keywords_hr><keywords_en><![CDATA[T cell memory, infection, cancer, Eomes, T cell receptor]]></keywords_en><summary_hr><![CDATA[Imunost posredovana CD8 T-limfocitima pruža nam zaštitu od brojnih patogena i tumora. Naivni repertoar limfocita T se sastoji od milijuna različitih klonova koji se međusobno razlikuju po specifičnosti svojih T-staničnih receptora. Prilikom infekcije, samo neki od klonova postaju dugovjeke memorijske stanice. Selekcijski proces odabira memorijskih klonova reguliran je ravnotežom između specifičnosti i raznolikosti kako bi se osigurao učinkovit sekundarni odgovor te mogućnost prepoznavanja istih, mutiranih antigena. Mehanizmi koji kontroliraju raznolikost memorije još uvijek nisu razjašnjeni. Naša grupa je prepoznala Eomes kao ključni transkripcijski čimbenik za formiranje memorije, no kako pojačana ekspresija Eomesa rezultira stvaranjem imunološke memorije je idalje nepoznato.	U ovom projektu, istražit ćemo utjecaj intenziteta signala i aktivacije T-staničnog receptora na formiranje memorije putem Eomes-a. Prvo ćemo ispitati kako razlike u jačini stimulacije utječu na kvantitativnu i kvalitativnu aktivaciju glavnih nizvodnih komponenti te način na koji se taj signal prevodi u određenu razinu ekspresije Eomes-a. Paralelno, proučavat ćemo i način na koji Eomes pretvara taj aktivirajući signal određene jačine u molekularni proces koji rezultira stvaranjem imunološke memorije. U trećoj fazi projekta utvrditi ćemo ključne čimbenike koji posreduju tim procesima. Još bitnije, usredotočit ćemo se na čimbenike koji mogu imati terapeutsku primjenu kako bi testirali učinkovitost specifičnog ciljanja tih molekula na unaprjeđenje antitumorskih i antivirusnih cjepiva.	Ovdje predstavljeni projektni prijedlog, osim iznimne inovativnosti, ima velike izglede za uspjeh budući da se temelji na velikoj količini preliminarnih rezultata. Uz to, jedna od ključnih prednosti je i naše dugogodišnje iskustvo i rad u području imunologije i istraživanja na životinjama. Stoga držimo da je ovaj projekt izvrsna investicija u hrvatsku akademsku zajednicu koja pomaže razvoju nove istraživačke grupe.]]></summary_hr><summary_en><![CDATA[CD8 T cell mediated immunity protects us against pathogens and cancer. The naive T cell pool consists of millions of clones, each one unique based on its T cell receptor (TCR). Upon infection, only a few of these clones are recruited to generate antigen-specific memory. Selection of memory clones is a trade-off between specificity and diversity to ensure both an efficient recall response and recognition of a sufficient number of targets. Mechanisms controlling memory diversity are largely unclear. Recently, we have identified the transcription factor Eomes as a key mediator of memory formation. How Eomes induction results in shaping of the memory cell pool is currently unknown.  	In this project, we will study the impact of activating T cell receptor signal intensity on memory formation via the transcription factor Eomes. First, we will investigate how TCR signal strength impacts the quality and quantity of activation of its main downstream components and how this translates into the activation of Eomes. In parallel, we will investigate how Eomes translates TCR-activating stimuli of a given strength in a molecular process that promotes memory formation. Using the combined information of these two lines of inquiry, we will identify and validate key factors that mediate these processes in the third phase of the project. Importantly, we will select for molecules that can be targeted by pharmacological means. Finally, we will test the potency of therapeutic intervention for the improvement of antiviral and anti-cancer vaccines. 	The proposal described here is both innovative, and has a high chance of success, since it is based on a large amount of preliminary data. This project builds on the strengths that our department has developed in the fields of immunology and animal research, while adding a fresh impulse of innovation. We therefore believe that this project is a solid investment in Croatian academia and aids in the development of a strong new research group. ]]></summary_en></project><project>
<id>8093</id><title_hr><![CDATA[Aktivnošću i in silico usmjeren dizajn malih bioaktivnih molekula]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5462</user_id><user_firstLast_name>Tomica Hrenar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-3416</code><acronim><![CDATA[ADESIRE]]></acronim><duration>06.06.2019 - 06.10.2023</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>28772</team_members_id><team_members_names><![CDATA[ Doktorand: Ana Mikelić ]]></team_members_names><keywords_hr><![CDATA[dizajn bioaktivnih molekula, sinteza, bioaktivnost, molekularno modeliranje, doking, multi-way analiza]]></keywords_hr><keywords_en><![CDATA[design of bioactive small molecules, synthesis, bioactivity, molecular modelling, docking, multi-way analysis]]></keywords_en><summary_hr><![CDATA[U ovom projektu predložena je sinteza, karakterizacija i biološka evaluacija novih tipova spojeva te ekstenzivni kvantno-kemijski proračuni i multi-way analize. Bioaktivni kemijski skeletni tipovi kao što su benzimidazoli, imidazoli i kinuklidini prepoznati su kao spojevi sa širokim spektrom bioloških aktivnosti, također i u području infektivnih bolesti te poremećaja središnjeg živčanog sustava (Alzheimerova bolest, AD). Mi predviđamo da bi daljnja istraživanja tih klasa kemijskih spojeva mogla rezultirati s identifikacijom novih spojeva prikladnih za daljnji razvoj u moguće lijekove. Kao jako inovativni dio ovog istraživanja, a za razvoj točnih kvantitativnih modela povezivanja strukture i reaktivnosti bit će korištene napredne metode molekularnog modeliranja u kombinaciji s multi-way analizama. Ti modeli će se iskoristiti za iterativni postupak usmjerenog racionalnog dizajna. U početku će se korištenjem klasičnih i suvremenih metoda organske kemije sintetizirati novi bioaktivni spojevi. Za priređene kiralne spojeve odredit će se stereoselektivnost njihovih interakcija. Za sve spojeve, odredit će se antimikrobna aktivnost osobito prema rezistentnim Gram-negativnim bakterijama. Nadalje, njihov potencijal za razvoj poboljšanih lijekova za AD odredit će se mjerenjem njihove inhibicije kolinesteraza. Za procjenu mogućih pozitivnih sinergijskih učinaka, sintetizirat će se hibridne molekule te će se testirati i smjese najaktivnijih sintetiziranih spojeva. Molekularno modeliranje, doking simulacije i novorazvijena metodologija za primjenu multi-way analiza na kombinirane eksperimentalne i teorijske podatke koristit će se za ciljane strukturne promjene koje bi mogle dovesti do novih i efikasnijih bioaktivnih skeletnih tipova s potencijalnom primjenom u biotehnologiji, farmaceutskoj industriji i medicini.]]></summary_hr><summary_en><![CDATA[In this project synthesis, characterization, and biological evaluation of novel types of compounds including extensive quantum chemical calculations and multi-way analyses is proposed. Bioactive chemical scaffolds such as benzimidazoles, imidazoles, and quinuclidines are recognized as compounds with a broad spectrum of biological activities also in the fields of infectious diseases and central nervous system disorders (Alzheimer’s disease, AD). We envisioned that further exploration of these chemical classes can result with the identification of new leads suitable for further development into potential hits. As a highly innovative part of this study, advanced methods of molecular modelling combined with multi-way analysis will be used for construction of accurate quantitative structure–activity relationship models. These models will be used for iterative procedure of guided rational design. Initially, new bioactive compounds will be synthesized using classical and contemporary methods of organic chemistry. Chiral compounds will be prepared and the stereoselectivity of interactions evaluated. For all compounds, antimicrobial activity will be estimated targeting resistance genes to treat infections caused by multidrug-resistant Gram-negative bacteria. Furthermore, their perspective for development of enhanced anti-AD drugs will be assessed by determining their inhibitory potency toward cholinesterases. To evaluate possible beneficial synergistic effects, hybrid molecules as well as various combinations of the most active synthesized compounds will be prepared and tested. Molecular modelling, docking studies and a newly developed method for application of multi-way analysis to combined experimental and theoretical data will be used to direct structural changes leading to the synthesis of new, more efficient bioactive scaffolds with potential use in biotechnology, pharmaceutical industry and medicine.]]></summary_en></project><project>
<id>8094</id><title_hr><![CDATA[Epidemiologija hipertenzije i unos kuhinjske soli u Hrvatskoj ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6539</user_id><user_firstLast_name>Vanja Vasiljev</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-7966</code><acronim><![CDATA[EH-UH 2]]></acronim><duration>01.04.2019 - 16.01.2026</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Javno zdravstvo i zdravstvena zaštita, </scie_field_hr><scie_field_en>Public health and health services, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Medicine]]></institution_en><team_members_id>25935</team_members_id><team_members_names><![CDATA[ Doktorand: Mihaela Marinović Glavić ]]></team_members_names><keywords_hr><![CDATA[hipertenzija, kuhinjska sol, epidemiologija, prevalencija, svjesnost, liječenje, kontrola]]></keywords_hr><keywords_en><![CDATA[hypertension, salt intake, epidemiology, prevalence, awareness, treatment, control]]></keywords_en><summary_hr><![CDATA[Arterijska hipertenzija (AH) je vodeći uzrok pobola i smrti u svijetu pa tako i u Hrvatskoj.Prema podacima nacionalne EH-UH studije koja je završena prije 10 godina prevalencija je 37%, uz vrlo lošu kontrolu od oko 20%. Jedan od glavnih razloga velike prevalencije  i loše kontrole je prekomjeran unos kuhinjske soli koji prema rezultatima našeg istraživanja u Hrvatskoj iznosi preko 11 grama dnevno.Ti podaci su bili temelj za Strateški plan vlade Republike Hrvatske za smanjivanje prekomjernog unosa kuhinjske soli.Ciljevi ovoga projekta su:1)na temelju podataka iz arhive EH-UH 1 studije pozvati na kontrolni pregled sve ispitanike, pratiti klinički tijek i ishod ovisno o ulaznim pokazateljima;2)na način kako je rađeno u EH-UH 1 u EH-UH 2 skupini randomizirati novi uzorak opće populacije u cijeloj Hrvatskoj,koristiti isti upitnik,preglede,mjerenja arterijskoga tlaka i određivanja pridruženih čimbenika rizika te odrediti prevalenciju, svjesnost, liječenje i kontrolu hipertoničara, te odrediti dinamiku kretanja u Hrvatskoj tijekom perioda od 10 godina;3)u obje skupine (EH-UH1 i EH-UH2) odrediti unos kuhinjske soli mjerenjem 24-satne natriurije (zlatni standard za dnevnu procjenu unosa kuhinjske soli);4)u istom uzorku urina odrediti količinu joda kako bismo dobili podatak o sigurnosti smanjivanja unosa kuhinjske soli.Rezultati ovoga projekta omogućit će određivanje koji čimbenici najznačajnije utječu na progresiju AH i povezani su s fatalnim i nefatalnim ishodima;dobit ćemo podatak o dinamici kretanja prevalencije i kontroli AH u Hrvatskoj. Napose dobit ćemo podatak o kretanju unosa kuhinjske soli i povezanosti s AT, te o unosu joda. Dobiveni podaci koristit će kod planiranje strategija s ciljem podizanja kontrole AH i posljedično smanjivanja kardiovaskularnog, cerebrovaskularnog i renalnog rizika, a bit će važni i na međunarodnom planu u pregovorima Europskog društva za hipertenziju s Europskom komisijom.]]></summary_hr><summary_en><![CDATA[Hypertension (HT) is leading cause of morbidity and mortality worldwide and in Croatia. According to results from nationwide EH-UH study done 10 years ago, prevalence was 37%, with very poor control rate (20%). One of the major causes of high prevalence and poor control rate is excessive intake of salt. One of our study showed that the daily intake of salt in Croatia is around 11 grams. Data from that study were ground stone for Strategic Plan of the Government of Republic of Croatia for reducing excessive salt intake. Aims of this project are: 1) based on the archive of EH-UH 1 study do the follow-up of all the participants, to assess clinical course and outcome regarding entry data; 2) in EH-UH 2, following same methodology from EH-UH 1, to enroll new random sample of general population of entire Nation, use same questionnaire, means of physical exam and blood pressure measurements; to determine associated risk factors and to obtained prevalence, awareness, treatment and control rate of HT and to define the trend in Croatia in last 10 years; 3) salt intake will be assessed by measuring 24-hour natriuresis in both samples (EH-UH 1 and EH-UH 2), procedure considered to be the gold standard for daily table salt intake; 4) intake of iodine will be assessed from the same urine sample in order to avert suspicions that lowering salt intake will lead to  hypoiodinemia. Results from this research will help to define the factors with strongest impact on HT progression and are related with fatal and nonfatal events; data about prevalence and control rate of HT in Croatia will be obtained. Particularly, data on table salt intake and its impact on HT will be retrieve, along with iodine intake levels. Given data will be of use for planning further strategies for increasing HT control, and by that mean lowering overall cardiovascular cerebrovascular and renal risk. Also, data will suffice for European society of hypertension in its negotiations with European commission]]></summary_en></project><project>
<id>8095</id><title_hr><![CDATA[Razvoj održivog integriranog procesa proizvodnje biološki aktivnih izolata iz proizvodnih ostataka prehrambene industrije]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4070</user_id><user_firstLast_name>Ana  Bucić-Kojić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-6203</code><acronim><![CDATA[POPI-WinCEco]]></acronim><duration>20.02.2019 - 20.11.2023</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Prehrambena tehnologija, </scie_field_hr><scie_field_en>Food technology, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Prehrambeno-tehnološki fakultet]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Food Technology]]></institution_en><team_members_id>25658</team_members_id><team_members_names><![CDATA[ Doktorand: Josipa Grgić ]]></team_members_names><keywords_hr><![CDATA[proizvodni ostaci, biološki aktivni izolati, polifenoli, biološka obrada, ekstrakcija, sušenje, enkapsulacija, funkcionalni proizvod, bioraspoloživost]]></keywords_hr><keywords_en><![CDATA[food industry residues, bioactive isolates, polyphenols, biological treatment, extraction, drying, encapsulation, functional product, bioaccessibility]]></keywords_en><summary_hr><![CDATA[U prehrambenoj industriji zaostaju značajne količine proizvodnih ostataka (POPI) koji se uglavnom odbacuju iako po svom kemijskom sastavu imaju potencijal za daljnje korištenje u proizvodnji visokovrijednih produkata (npr. biološki aktivnih izolata bogatih polifenolnim spojevima, BAI). POPI biljnog porijekla su uglavnom teško razgradivi lignocelulozni materijali koji u svojoj strukturi sadrže inkorporirane polifenole, koji su zbog toga teško ekstraktibilni ili imaju nisku bioraspoloživost. Ekstrakcija teško topljivih polifenola zahtjeva dodatne postupke razgradnje (npr. kiselinama ili komercijalnim enzimima), koji povećavaju troškove proizvodnje i/ili nisu ekološki prihvatljivi. Fermentacija na čvrstim nosačima (solid-state fermentation, SSF) je bioproces koji ima veliki potencijal za pretvorbu otpada poljoprivredne i prehrambene proizvodnje u visokovrijedne produkte, među kojima su i BAI, na ekološki prihvatljiv način. Cilj ovog projekta je razviti održivi integrirani proces proizvodnje BAI-a iz POPI-a (trop grožđa; mekinje i pljevica žitarica) biljnog porijekla, pri čemu će se POPI prvo obraditi filamentoznim gljivama u SSF uvjetima, nakon čega će se koristiti za proizvodnju BAI a pomoću ekstrakcije otapalom. Razvit će se i protokoli stabilizacije BAI-a, primjenom suvremenih tehnologija (enkapsulacijom, sušenjem raspršivanjem, liofilizacijom), te će se odrediti antioksidacijska i antitumorska aktivnost BAI-a u in vitro uvjetima. Proizvedeni BAI koristiti će se kao dodaci u proizvodnji funkcionalnog keksa i srodnih proizvoda. Simuliranim procesom probave u in vitro uvjetima, ispitat će se bioraspoloživost polifenola iz BAI-a i funkcionalnog keksa. Rezultati predloženog projekta imat će pozitivne ekonomske i društvene utjecaje kroz razvoj ekološki prihvatljivog procesa proizvodnje BAI-a, minimiziranje količine otpada iz prehrambene industrije, povećanje dodane vrijednosti proizvoda, te indirektan utjecaj na ljudsko zdravlje kroz proizvodnju funkcionalnih proizvoda.]]></summary_hr><summary_en><![CDATA[There are significant amounts of residues from the food industry (POPI) which are usually discarded even though their chemical composition gives them the potential to be further used in the production of high-value products (e.g. biologically active polyphenol rich isolates, BAI). The POPI of plant origin are mostly lignocellulosic materials recalcitrant towards degradation, and incorporate polyphenolic compounds in its structure. Those polyphenolic compounds are difficult to be extracted, thus have low bioaccessibility. Extraction of low soluble polyphenols requires additional processes of degradation by e.g. acids or commercial enzymes, which increase the costs of production and/or are not environmentally friendly. Solid-state fermentation (SSF) has a great potential for conversion of agro-food industry residues into numerous high-value products, including BAI, in an environmentally friendly way. The goal of this project is to develop a sustainable integrated process for the production of BAI from POPI (grape pomace; bran and hull of cereals) where the POPI will be initially treated with filamentous fungi in SSF conditions. After the treatment it will be used for the production of BAI using solvent extraction. Protocols for the stabilization of BAI will be developed by using state-of-the-art technologies (spray drying, freeze-drying, encapsulation) and antioxidative and antitumor activity of BAI will be determined in in vitro conditions. Stable BAI will be used in the production of functional cookies and crackers. Through the simulated process of digestion in in vitro conditions, polyphenol bioaccessibility from the BAI and functional products will be tested. The results of the proposed project will have positive economic and social effects through development of environmentally friendly process for BAI production, minimization of food industry waste, increase of added product value, and indirect impact on human health through development of functional products.]]></summary_en></project><project>
<id>8096</id><title_hr><![CDATA[CROSSBOW (CROSS BOrder management of variable renewable energies and storage units enabling a transnational Wholesale market)]]></title_hr><title_en><![CDATA[]]></title_en><user_id>7162</user_id><user_firstLast_name>Hrvoje Pandžić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-5900</code><acronim><![CDATA[]]></acronim><duration>04.03.2019 - 03.08.2023</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>25844</team_members_id><team_members_names><![CDATA[ Doktorand: Karlo Šepetanc ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>8097</id><title_hr><![CDATA[Hrvatski mrežni rječnik]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5200</user_id><user_firstLast_name>Milica Mihaljević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-7416</code><acronim><![CDATA[MREŽNIK]]></acronim><duration>01.05.2019 - 01.05.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filologija, </scie_field_hr><scie_field_en>Philology, </scie_field_en><institution_hr><![CDATA[Institut za hrvatski jezik]]></institution_hr><institution_en><![CDATA[Institute of Croatian Language]]></institution_en><team_members_id>26889</team_members_id><team_members_names><![CDATA[ Doktorand: Maja Matijević ]]></team_members_names><keywords_hr><![CDATA[mrežni rječnik, hrvatski rječnik, jednojezični rječnik,  hipertekstni rječnik, e-leksikografija, e- rječnik, rječnik utemeljen na korpusu]]></keywords_hr><keywords_en><![CDATA[web dictionary, Croatian dictionary, monolingual dictionary,  hipertext dictionary; e-leksicography, e- dictionary, corpus based dictionary]]></keywords_en><summary_hr><![CDATA[U okviru projekta Hrvatski mrežni rječnik (MREŽNIK) izradit će se slobodno dostupan, jednojezični, hipertekstni, jednostavno pretraživ mrežni rječnik hrvatskoga standardnoga jezika od 10 000 natuknica koji će omogućivati interakciju s korisnicima. Natuknice i pojedine riječi i izrazi u rječničkim člancima povezivat će se unakrižno i s natuknicama u bazama podataka koje će nastati u okviru ovoga projekta (baza jezičnih savjeta, baza veznika s opisom vezničkih skupina i njihove modifikacije, baza objašnjenja podrijetla frazema, baza etnika i ktetika). Uz osnovne, rječnik će uključivati i školske definicije (3000) i definicije za strance (1000). Rječnik će biti utemeljen na kopusu (Hrvatska mrežna riznica i Hrvatski mrežni korpus). Uz te će se izvore uzimati u obzir pri uspostavi definicija, donošenju primjera i značenja i svi drugi dostupni tiskani i mrežni izvori. Rječnik će se pisati u programu TLex, prilagođenu za potrebe projekta, a za uvid u korpus upotrijebit će se mrežni alat za pretragu korpusa SketchEngine. Nakon završetka leksikografske obradbe, podatci će biti izvezeni iz TLexa te izrađena mrežna aplikacija rječnika. U okviru projekta predviđena je: 1. izradba temeljnoga rječnika od 10 000 natuknica; 2. izradba popratnih baza i njihovo povezivanje s temeljnim rječnikom; 3. povezivanje temeljnoga rječnika s drugim mrežnim izvorima koji se trenutačno izrađuju u Institutu za hrvatski jezik i jezikoslovlje (bazom glagolskih  valencija, kolokacija, hrvatskoga strukovnog nazivlja, Repozitorijem hratskih metafora, mrežnim stranicama Bolje je hrvatski (bolje.hr)); 4. izradba odostražnoga rječnika.MREŽNIK je zamišljen kao dinamični rječnik koji nakon završetka projektnoga razdoblja otvara mogućnost daljnjega dopunjivanja.]]></summary_hr><summary_en><![CDATA[As a part of the MREŽNIK (Croatian Online Dictionary) project, the online monolingual dictionary of Standard Croatian language with ten thousand dictionary entries will be compiled. The dictionary will be free, easy to search, it will allow interaction with users and will contain hypertext links. The dictionary entries will contain links to certain other words, expressions and repositories (Linguistic Advice Repository, Conjunction Repository, etc.). The dictionary will be corpus based (Croatian Language Repository and Croatian Web Corpus), but other sources, online and printed, will be taken into account when looking for example sentences and writing entry definitions.The dictionary will be compiled using TLex, a professional software application for compiling dictionaries. SketchEngine will be used to search the corpus. After the completion of the dictionary entries, the data will be exported from TLex, and the Web application will be developed.   The project will:1. compile the basic dictionary consisting of ten thousand entries;2. develope additional repositories and connect them with the basic dictionary; 3. connect the basic dictionary with other online resources which are currently being developed at the Institute of Croatian Language and Linguistics: (The Verb Valence Repository, The Collocation Repository, The Croatian Special Field Terminology of Croatian repository (Struna), The Etymological Dictionary of Croatian, The Croatian Metaphor Repository, website bolje.hr;4. compile a reverse dictionary.MREŽNIK is conceived as a dynamic dictionary, the development of which will not end at the end of the project.]]></summary_en></project><project>
<id>8098</id><title_hr><![CDATA[Implicitna ličnost, donošenje odluka i vođenje u organizacijama]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6601</user_id><user_firstLast_name>Maja Parmač Kovačić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-8732</code><acronim><![CDATA[IMPEDEMOL]]></acronim><duration>14.06.2019 - 13.09.2023</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Psihologija, </scie_field_hr><scie_field_en>Psychology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>27640</team_members_id><team_members_names><![CDATA[ Doktorand: Antun Palanović ]]></team_members_names><keywords_hr><![CDATA[vođenje u organizacijama, implicitna ličnosti, motiv za moći, testovi uvjetovanog rezoniranja,  individualne razlike u donošenju odluka]]></keywords_hr><keywords_en><![CDATA[organizational leadership, implicit personality, power motive, conditional reasoning tests,  individual differences in decision-making]]></keywords_en><summary_hr><![CDATA[Menadžeri i rukovoditelji u organizacijama odgovorni su za motiviranje zaposlenika, donošenje kvalitetnih odluka i izgradnju timova koji će s vremenom postizati dobre rezultate. Oni su ključni za uspjeh i razvoj tvrtki, kao i za motivaciju i dobrobit podređenih. Ipak, istraživanja pokazuju da je više od pola menadžera neuspješno u svom poslu te ili sami daju otkaz ili bivaju otpušteni. Također, neke studije ukazuju na to da čak 50% odluka koje donesu visokopozicionirani menadžeri rezultiraju neuspjehom. Neovisno o sektoru ili poziciji unutar organizacijske hijerarhije, razlozi za neuspjeh menadžera uglavnom su povezani s nekim njihovim psihološkim karakteristikama.Smatramo da rukovoditelji utječu na organizacijske ishode putem skupa kompetencija koje čine njihov rukovoditeljski potencijal. Rukovoditeljski potencijal dijelom ovisi o ličnosti i kompetentnosti u  donošenju odluka. Kroz ovaj projekt, pokušat ćemo istražiti mogu li novije spoznaje u području mjerenja implicitne ličnosti doprinijeti istraživanju rukovođenja u organizacijama. Također, u skladu s novijim prijedlozima o potrebi integracije spoznaja iz područja psihologije rada i organizacijske psihologije s onima iz područja prosuđivanja i donošenja odluka, istražit ćemo kako je uspješnost u rukovođenju povezana s individualnim razlikama u odlučivanju.Kao ishod ovog projekta, planiramo razviti i empirijski validirati bateriju psihologijskih testova za odabir i razvoj menadžera, koja će biti bazirana na najnovijim znanstvenim spoznajama u području selekcije i menadžmenta. Baterija će se sastojati od testova implicitne ličnosti temeljenih na paradigmi uvjetovanog rezoniranja, instrumenata za mjerenje individualnih razlika u donošenju odluka i testa situacijskih prosudi za procjenu rukovoditeljskog potencijala.]]></summary_hr><summary_en><![CDATA[Managers or organizational leaders are responsible for motivating their employees, making good decisions, and building teams that produce results over time. They are crucial for success and development of companies as well as for motivation and well-being of their subordinates. Still, recent research shows that about half of managers are unsuccessful in their jobs and either resign or get fired. Moreover, some studies showed that important decisions by top managers in at least 50% of cases result with failure.  Irrespective of the type of industry or exact level of the position in an organizational hierarchy, the reasons for managerial derailment are typically related to some psychological characteristics of the leaders.We believe that leaders affect organizations through a set of competencies that make their leadership potential, and that, in turn, determine their performance.  The leadership potential and leadership performance are to a large extent a function of leaders’ personality, and decision-making competencies. Within the project, we will try to explore how recent advances in implicit personality assessment could contribute to organizational leadership research. Moreover, in accordance with recent calls to integrate work and organizational psychology with decision-making literature, we will try to explore how is leadership performance related to individual differences in decision-making. As an outcome of this research project, we plan to develop and empirically test a battery of psychological instruments for selection and development of managers that is based on recent advances in personnel selection and management literature. The battery will consist of the tests of implicit personality based on the conditional reasoning paradigm, instruments for measurement of individual differences in decision-making and a situational judgment test for the assessment of leadership potential.]]></summary_en></project><project>
<id>8099</id><title_hr><![CDATA[DNA kao dokaz o distribuciji i vitalnosti ugrožene balkanske divokoze]]></title_hr><title_en><![CDATA[]]></title_en><user_id>19869</user_id><user_firstLast_name>Toni Safner</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-2894</code><acronim><![CDATA[BalkCham]]></acronim><duration></duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Agronomski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Agriculture]]></institution_en><team_members_id>25973</team_members_id><team_members_names><![CDATA[ Doktorand: Toni Tešija ]]></team_members_names><keywords_hr><![CDATA[R. rupicapra balcanica, SNP, MHC, efektivna veličina populacije, inbreeding, populacijska struktura, Dinarske planine]]></keywords_hr><keywords_en><![CDATA[R. rupicapra balcanica, SNP, MHC, effective population size,  inbreeding, population structure,Dinaric mountains]]></keywords_en><summary_hr><![CDATA[Model vrsta projektnog prijedloga je balkanska divokoza (R. rupicapra balcanica), populacija sjeverozapadnih Dinarida u Hrvatskoj. Kao karizmatični papkar, balkanska divokoza, vodeća je vrsta kod očuvanja planinskog ekosustava Balkanskog poluotoka koji je jedan od 35 svjetski važnih lokaliteta biološke raznolikosti. Zbog mala veličina populacije i niska genetska varijabilnost populacija divokoza u Dinaridima podložna je mnogim čimbenicima. Sa svim dosadašnjim spoznajama, glavni cilj našeg projekta je analizirati genetsku strukturu balkanske divokoze, koristeći neutralni (SNP) biljeg i biljeg pod selekcijom (MHC kompleks) za procjenu statusa zaštite i proučiti mehanizme molekularne adaptaciji lokalne populacije. Nadalje, ekstrakcija DNA iz lubanja divokoza odstrjeljenih prije reintrodukcije i usporedba uspješnih sekvenci sa današnjim iz genske banke, te potencijalno rekonstruirati filogeografiju divokoza s Velebita. Okolišna i staništa analiza u GIS-u  provest će se analizom prisutnosti i godišnje migracije životinja. Sve to će se postići interdisciplinarnim istraživačkim timom sastavljenim od agronoma, biologa, šumara i veterinara. Rezultati našeg projekta će pružiti uvid u distribuciju i vitalnost, što je važno u uspostavljanju učinkovitog upravljanja buduće populacije divokoza u Dinaridima. Isto tako moramo biti svjesni da je biološka raznolikost kulturna baština stoga nam je dužnost zaštititi balkansku divokozu za buduće generacije.]]></summary_hr><summary_en><![CDATA[The model species of the project proposal is Balkan chamois (R. rupicapra balcanica), specifically population of the northwestern Dinaric Mountains in Croatia. As a charismatic ungulate, Balkan chamois, is an excellent flagship species for the conservation of the montane ecosystems of the Balkan Peninsula which is one of the world’s 35 biodiversity hotspots. The small population size and low genetic variability of the chamois populations in the Dinaric Mountains make them vulnerable to many factors. With all previous findings considered, main goal of our project is to analyse genetic structure of Balkan chamois, using neutral (SNP) and loci under selection (MHC complex) to estimate conservation status and to study mechanisms of molecular adaptation of local populations. Furthermore, DNA extraction from hunted chamois before reintroduction and comparison of successful sequences with contemporary ones from Gen bank, and potential reconstruction of phylogeography of chamois from Velebit Mountain. An environmental and habitat analyses in GIS will carry out to analysis of habitat occupation and annual migration of animals. This will be achieved by interdisciplinary research team composed of agronomist, biologists, forester and veterinarians. Results of our project will provide insights of distribution and vitality, what is important in establishment of the effective future management of chamois population in Dinaric Mountains. Also we must be aware that biodiversity is a cultural heritage and it is important to protect Balkan chamois for future generations.]]></summary_en></project><project>
<id>8100</id><title_hr><![CDATA[Demistificiranje dvočestičnih korelacija u pp sudarima s nadograđenom komorom vremenske projekcije]]></title_hr><title_en><![CDATA[]]></title_en><user_id>7691</user_id><user_firstLast_name>Mirko Planinić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-7970</code><acronim><![CDATA[TPCwithTPC]]></acronim><duration>10.10.2019 - 09.04.2024</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>28908</team_members_id><team_members_names><![CDATA[ Doktorand: David Karatović  ]]></team_members_names><keywords_hr><![CDATA[Dvočestične korelacije, Kvarkovsko-gluonska plazma, TPC, GEM, Iskrenje, RIDGE]]></keywords_hr><keywords_en><![CDATA[Two particle correlations, Quark-Gluon Plasma (QGP), TPC, GEM, sparking, RIDGE]]></keywords_en><summary_hr><![CDATA[Primarni cilj ovog projekta je istražiti dvočestične korelacije čestica u sudarima protona (pp) koristeći varijable oblika događaja koje je naša grupa u prethodnim analizama opsežno koristila. 2010. g. izmjerena je izražena struktura u dvodimenzionalnoj funkciji angularnih korelacija za parove čestica kod malih azimutalnih kutnih razlika delta phi i preko širokog raspona razlika pseudorapiditeta delta eta. Ta je struktura nazvana &#39;&#39;greben&#39;&#39;, a promatrana je u događajima s velikim multiplicitetom. Korelacija grebena prvi put se vidjela u sudarima teških iona u kojima znamo da se proizvodi kvarkovsko-gluonska plazma (QGP). Nedavno je opažena struktura grebena u pp događajima visokog multipliciteta kod 7 TeV. Greben u  pp događajima visokog multipliciteta potaknuo je spekulacije o formiranju QGP u malim sustavima. Nedavni rezultati ALICE-a o prvom opažanju povećanja stranosti u sudarima protona s velikim multiplicitetom također nam govore da još ne razumijemo mehanizam formiranja QGP. Korištenje metoda razvijenih u PI grupi može pomoći u razumjevanju podrijetla strukture &#39;&#39;grebena&#39;&#39; novom metodom eliminiranja pozadine koju je već uspješno koristila naša grupa.  Sekundarni cilj ovog projekta je demistificirati pojavu iskrenja  GEM detektora  koji se koriste za TPC nadogradnju ALICE detektora na CERN-u. PI je utemeljio GEM laboratorij s čistom sobom koristeći prijašnji  UKF projekt i grupa je već stekla značajno iskustvo s GEM folijama. GEM folije su sastavni dio nadolazeće nadogradnje ALICE detektora, budući da su neophodne za planirane  pp i teškoionske sudare velikog luminoziteta. Ova nadogradnja je također motivirana otvorenim pitanjima u QGP-u, budući da će run velikog luminoziteta rezultirati značajnim povećanjem količine podataka koji se koriste za QGP analize.]]></summary_hr><summary_en><![CDATA[The primary objective of this project is to explore two particle correlations in proton-proton (pp) collisions using event shape variables extensively used by our group in previous analyses. In 2010, a pronounced structure in the two-dimensional angular correlation function was measured for particle pairs at small azimuthal angle differences delta phi and over a wide range of pseudorapidity differences delta eta. This structure was named the “ridge” and is observed in events with sufficiently high multiplicity. The ridge correlation was first seen in those heavy ion collisions for which we firmly believe that quark-gluon plasma (QGP) is produced.Recently, the ridge correlation was also observed in high-multiplicity pp events at 7 TeV. The appearance of this “ridge-like” structure in high-multiplicity pp events caused speculation for the formation of QGP in small systems. Recent ALICE results of the first observation of strangeness enhancement in high-multiplicity pp collisions are also telling us that we do not yet understand the mechanism of QGP formation. Using the methods developed in the PI’s group may help understand the origin of “ridge-like” structures by a novel background elimination method which was already successfully used by our group. The secondary objective of this project is to demystify the occurrence of sparking in Gas Electron Multiplier (GEM) detectors that are used for TPC upgrade of the ALICE detector at CERN. The PI has founded a GEM Lab with a clean room using a previous Unity through Knowledge Fund grant and the group has already gained significant experience with GEM foils. The GEM foils are an integral part of the upcoming ALICE detector upgrade, since they are essential for the planned high luminosity pp and heavy ion collisions at the LHC. This upgrade is also motivated by the open questions in QGP, since a high luminosity run will result in a significant increase in the data sample used for QGP analyses. ]]></summary_en></project><project>
<id>8101</id><title_hr><![CDATA[Influence of redox status on psychostimulant-induced neural plasticity]]></title_hr><title_en><![CDATA[]]></title_en><user_id>69</user_id><user_firstLast_name>Rozi Andretić Waldowski</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-8734</code><acronim><![CDATA[DrugPlast]]></acronim><duration>04.03.2019 - 03.11.2023</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci]]></institution_hr><institution_en><![CDATA[University of Rijeka]]></institution_en><team_members_id>28669</team_members_id><team_members_names><![CDATA[ Doktorand: Franka Rigo ]]></team_members_names><keywords_hr><![CDATA[neuralna plastičnost, psihostimulansi, redoks, genetika, ponašanje, Drosophila]]></keywords_hr><keywords_en><![CDATA[neuronal plasticity, psychostimulants, redox, genetics, behavior, Drosophila]]></keywords_en><summary_hr><![CDATA[Opojne droge mijenjaju funkcije mozga i dovode do ovisnosti aktivirajući mehanizme neuralne plastičnosti. Drosophila melanogaster je do sada uspješno korištena kao model organizam za ispitivanje utjecaja opojnih droga na živčani sustav radi sličnosti na nivou gena, neurotransmitera i mehanizama kojima droge mijenjaju mozak.Naši preliminarni rezultati pokazuju da promjena redoks ravnoteže u Drosophile onemogućava razvoj lokomotorne senzitizacije na metamfetamin (METH) i kokain. Na osnovu tih otkrića predlažemo ispitati kako promijene u redoks ravnoteži utječu na neuralnu plastičnost izazvanu psihostimulansima. Naša hipoteza je da lokomotorna senzitizacija, kao oblik neuralne plastičnosti, ovisi o redoks stanju.Imamo tri glavna cilja:a) identificirati gene koji reguliraju redoks stanje i utječu na regulaciju lokomotorne senzitizacije na METH, b) identificirati u kojim dijelovima mozga je ekspresija gena koji reguliraju redoks stanje važna za regulaciju lokomotorne senzitizacije, i c) identificirati funkcionalne promijene na nivou otpuštanja biogenih amina, aktivacije antioksidativnih enzima i količine reaktivnih kisikovih vrsta koje su povezane s razvojem lokomotorne senzitizacije.Kako bi ostvarili te ciljeve koristiti ćemo niz komplementarnih pristupa koji će nam omogućiti da analiziramo neuralnu plastičnost na nivou ponašanja i genetike, transkriptomike, proteomike, elektrofiziologije i biokemije kako bi karakterizirali odgovorne gene i proteine.Ishodi ovoga projekta pridonijeti će razumijevanju osnovnih genetskih mehanizama koji su aktivirani opetovanom administracijom psihostimulansa. Očekujemo da će ishodi ovoga projekta pomoći u razumijevanju bazičnih principa neuralne plastičnosti općenito. Radi značajnog utjecaja redoks ravnoteže na stanične funkcije, naši rezultati mogu sugerirati jednostavne strategije za spriječavanje i tretman ovisnosti.]]></summary_hr><summary_en><![CDATA[Drugs of abuse change brain functioning and lead to addiction engaging mechanisms of neuronal plasticity. Drosophila melanogaster has successfully been used as a model organism to study action of addictive drugs on the nervous system because of the conservation at the levels of genes, neurotransmitters and mechanisms of change that drugs induce. Our preliminary data shows that in Drosophila the change in the redox balance interferes with the development of locomotor sensitization to methamphetamine (METH) and cocaine. Based on these findings we propose to investigate how do changes in the redox balance regulate drug-induced neuroplasticity. Our hypothesis is that locomotor sensitization, as one form of neuroplasticity, depends on redox status. We have three main objectives: a) to identify genes involved in redox regulation that affect development of locomotor sensitization to METH, b) to identify brain areas where expression of genes regulating redox balance is required for development of locomotor sensitization, and c) to identify functional changes at the level of the release of bigenic amines, activity of antioxidant enzymes and amount of reactive oxidative species that are correlated with development of locomotor sensitization. To achieve these objectives we will use number of different complementary approaches that will enable us to analyze neuronal plasticity at the level of behavior and genetics, transcriptomics, proteomics, electrophysiology and biochemistry to functionally characterize candidate genes and proteins.Outcomes of this study will contribute in the understanding of basic genetic mechanisms that are triggered with repeated administrations of psychostimulants. We expect that outcomes of this study will help in the understanding of basic principles of neuronal plasticity in general. Because of the wide influence of redox balance on cell functioning, our results may result in simple strategies for prevention and treatment of addiction.]]></summary_en></project><project>
<id>8102</id><title_hr><![CDATA[Nova generacija poluvodičkih elemenata i integriranih sklopova za eru Interneta stvari]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6955</user_id><user_firstLast_name>Tomislav Suligoj</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-7928</code><acronim><![CDATA[NexGenSemi]]></acronim><duration>01.03.2020 - 31.10.2024</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>22510</team_members_id><team_members_names><![CDATA[ Doktorand: Lovro Marković ]]></team_members_names><keywords_hr><![CDATA[Internet stvari, bipolarni tranzistor s horizontalnim tokom struje, pouzdanost, poluvodički fotodetektor, galij-nitrid, simulacije poluvodiča]]></keywords_hr><keywords_en><![CDATA[Internet of Things, Horizontal Current Bipolar Transistor, reliability, semiconductor photodetectors, gallium-nitride, semiconductor simulations]]></keywords_en><summary_hr><![CDATA[Cilj ovoga projekta je istražiti nove poluvodičke elemente i sklopove pogodne za primjenu na različitim nivoima Interneta stvari (eng. Internet-of-Things – IoT), od senzorskih čvorova, preo komunikacijskih sklopova, do elemenata za mrežnu infrastrukturu. Elektronički elementi i sklopovi za tako različite dijelove IoT sustava bit će istraženi u 3 područja: (i) Pouzdanost i pojačala snage u tehnologiji tranzistora sa horizontalnim tokom struje (HCBT), (ii) Projektiranje, karakterizacija i modeliranje blisko infracrvenih, vidljivih i UV fotodetektorskih prednjih krajeva, i (iii) Modeliranje i primjene GaN HEMT-ova.Doherty pojačalo snage i pojačalo za praćenje envelope kao primjeri visokoefikasnih RF pojačala snage za modulacije s velikim omjerom maksimalne i prosječne snage projektirat će se u HCBT tehnologiji koja ima nisku cijenu proizvodnje, a vrlo visoke performanse. To će biti prva RF pojačala snage s HCBT-ovima čime će se pokazati prikladnost tehnologije za sklopove s velikim signalom. Dodatno će se proučavati i pouzdanost HCBT elemenata s obzirom na pobudu jakim RF signalom i zračenjima.Uz proširenje našeg jedinstvenog električkog modela PureB materijala na siliciju za UV detektore, predloženi projekt bit će usmjeren i na visoko-osjetljive, blisko infra-crvene detektore implementirane u čistom galiju i PureB (PureGaB) na germaniju (Ge) nanesenom na Si supstrat, kao i na projektiranje detektora jednog fotona i njegove sklopove za potiskivanje proboja.Modeliranje GaN HEMT-a bit će istraženo pomoću fizikalno-baziranih modela. Transport elektrona u kanalu HEMT-a bit će modeliran samo-konzistentnim simulacijama mehanizama raspršenja, sa korijenima u kvantnoj mehanici, koji će uzeti u obzir kvantno ograničenje, strukturu energetskih pojaseva i sve relevantne mehanizme raspršenja.S obzirom na dosadašnja postignuća naše grupe, mogu se očekivati publikacije u vodećim znanstvenim časopisima i konferencijama kao i prijave patenata.]]></summary_hr><summary_en><![CDATA[The aim of this project is to conduct a research on novel semiconductor devices and circuits suitable for the Internet-of-Things (IoT) applications at various levels, to cover sensor nodes, communication circuits and devices for network infrastructure. Electron devices and circuits for such different parts of IoT systems will be researched in 3 areas: (i) Device reliability and power amplifiers (PAs) in Horizontal Current Bipolar Transistor (HCBT) technology, (ii) Design, characterization and modeling of near-infrared, visible and UV photodetector front-ends, and (iii) Modeling and applications of GaN HEMTs.The Doherty and Envelope tracking PAs with their high-efficiencies for high peak-to-average-power-ratio modulations will be designed in low-cost, high-performance HCBT technology. These will be the first RF power amplifiers with HCBTs demonstrating the suitability of HCBT technology for large-signal RF applications. Additionally, the reliability of HCBT devices will be tested against high RF power stress and radiation stresses.Besides extending our unique electrical model of PureB-on-Silicon material for UV detectors, the focus in the proposed project will also be on high-sensitivity, near-infra-red (NIR) detectors implemented in pure gallium and PureB (PureGaB) on germanium (Ge) grown on Si substrate together with the design of single photon avalanche detectors (SPADs) and their quenching circuits.The modeling of GaN high electron mobility transistor (HEMT) will be researched by physics-based models. The transport of electrons in HEMT channel will be assessed by self-consistent carrier scattering simulations, rooted in quantum mechanics that will take into account quantum confinement, bandstructure effects and all relevant scattering mechanisms.Based on a track record of the group, the publications in the top journals and conferences in the field and patent applications can be expected in this project.]]></summary_en></project><project>
<id>8103</id><title_hr><![CDATA[De novo sastavljanje genoma i metagenoma]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1480</user_id><user_firstLast_name>Mile Šikić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-8714</code><acronim><![CDATA[SIGMA]]></acronim><duration>01.09.2022 - 28.02.2026</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>865540</team_members_id><team_members_names><![CDATA[ Doktorand: Filip Tomas ]]></team_members_names><keywords_hr><![CDATA[de novo, assembly, genome, metagenome, seqeuncing]]></keywords_hr><keywords_en><![CDATA[de novo, sastavljanje, genom, metagenom, sekvenciranje]]></keywords_en><summary_hr><![CDATA[Prvi moderni alat za sastavljanje genoma proizvela je Celera 2001. godine za sastavljanje prve verzije ljudskog genoma. Od tada su mnoge metode za sastavljanje genoma razvijene i korištene, ali konačni genomi visoke preciznosti još uvijek zahtijevaju dugotrajan angažman istraživačkih skupina i dugotrajno ručno provjeravanje i prepravljanje. Najveći izazov u proizvodnji visoko preciznih i neprekinutih sastavljenih genoma su dugi nizovi ponavljajući regija. Nove i nadolazeće tehnologije za sekvenciranje tvrtki Pacific Biosciences i Oxford Nanopore Technologies daju nam nadu da je automatizacija postupka sastavljaja genoma moguća. Nove tehnologije proizvode očitanja velike duljine, ali i velikog postotka pogreške. Duljina proizvedenih očitanja može premašiti i nekoliko stotina tisuća nukleotida, što bi trebalo biti dovoljno za ispravnu rekonstrukciju većine ponavljajućih dijelova genoma. Međutim, znanstvena zajednica još uvijek ima značajne poteškoće prilikom sastavljanja većih genoma (genoma životinja i biljaka) te prilikom sastavljanja genoma mikrobnih zajednica. Metode za sastavljanje obično koriste pristup utemeljen na grafovima. Grafovi se grade spajajući očitanja koja se preklapaju, a zatim se heurističkim metodama traži put kroz graf koji će svako očitanje obići samo jednom. To je često nemoguće zbog petlji u grafu, uzrokovanih neispravnim preklapanjima i ponavljajućim djelovima genoma. To je posebno izraženo kod dugih genoma koji se sastoje od većeg broja kromosoma te kod metagenomeskih uzoraka koji sadrže od desetak pa do nekoliko stotina organizama. Glavni cilj ovog projekta jest razviti metode pomoću kojih koje će se proizvesti (i) potpuni i precizni dugi genomi te (ii) genomi organizama iz metagenomskog uzorka. Da bi to postigli planiramo razviti nekoliko metoda utemeljenih na grafovima i strojnom učenju pomoću kojih ćemo detektirati neispravna preklapanja.]]></summary_hr><summary_en><![CDATA[The first modern software for DNA assembly was developed by Celera for generating the draft of human genome in 2001. Since then ample of methods have tried to correctly assemble genomes, but a high-quality assembly still requires laborious work of large groups of scientists and many years of data curation. The biggest challenges for achieving high accuracy and contiguity of genome assemblies have been long stretches of highly repetitive regions. The recent advent of new generation of sequencing technologies such as those of companies Pacific Biosciences and Oxford Nanopore Technologies gives us hope that automated complete genome reconstruction is feasible. They produce long, but error-prone reads whose size exceeds hundreds of thousand nucleotides which should be long enough for spanning most repetitive parts. Nevertheless, researchers still struggle to completely assemble long genomes (ie. animal and plant genomes) and genomes of microbial communities. Assembly methods usually use a graph-based approach which starts with building a graph by joining overlapping reads, followed by using heuristics to find a path which visits each read once. However, this is often unfeasible because of tangles in the graph which occur due to incorrect read overlaps and repetitive regions. This is particularly critical for both long genomes with many chromosomes and for metagenomic samples with anything from ten to several hundred present genomes. The primary aim of this project is the development of methods which will result in (i) complete large genomes and (ii) accurate metagenomic assemblies. To achieve this aim we will develop several graph-based and machine learning methods for detection of incorrect overlaps.]]></summary_en></project><project>
<id>8104</id><title_hr><![CDATA[A new class of microtubules in the spindle exerting forces on kinetochores (NewSpindleForce)]]></title_hr><title_en><![CDATA[]]></title_en><user_id>11207</user_id><user_firstLast_name>Iva Tolić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-5724</code><acronim><![CDATA[]]></acronim><duration>06.05.2019 - 06.11.2023</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>26497</team_members_id><team_members_names><![CDATA[ Doktorand: Monika Trupinić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>8105</id><title_hr><![CDATA[Metoda usvojenih deformacija za konačne elemente slojevitih ploča i ljuski i njena primjena na probleme delaminacije ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1014</user_id><user_firstLast_name>Dragan Ribarić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-6185</code><acronim><![CDATA[ASDEL]]></acronim><duration>15.03.2019 - 14.08.2023</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Interdisciplinarne tehničke znanosti, </scie_field_hr><scie_field_en>Interdisciplinary technological sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Građevinski fakultet u Rijeci]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Civil Engineering]]></institution_en><team_members_id>26077</team_members_id><team_members_names><![CDATA[ Doktorand: Ivan Hlača ]]></team_members_names><keywords_hr><![CDATA[teorija ploča, metoda konačnih elemenata, usvojene interpolacije deformacija, uslojene ploče, uslojene ljuske, delaminacija]]></keywords_hr><keywords_en><![CDATA[plate theory, finite element method, assumed strain, layered plates, layered shells, delamination]]></keywords_en><summary_hr><![CDATA[Predlažemo istraživački projekt iz bazičnih tehničkih znanosti koji će se baviti numeričkim analizama Mindlinovih tipova umjereno debelih ploča pomoću metode konačnih elemenata. Temeljem naših dobrih rezultata kod dizajniranja četverostraničnih i trostraničnih pločastih elemenata (s različitim brojem čvorova) uz pomoć metode usvojenih interpolacija deformacija a za formuliranje njihove matrice krutosti, predlažemo proširenje istraživanja na uslojene ploče u 2D prostoru i uslojene ravne i zakrivljene ljuske u 3D prostoru.Materijal koji povezuje slojeve će se u početnoj fazi opisti elastičnim konstitutivnim zakonom, ali slijedom naših uspješnih numeričkih eksperimenata na uslojenim gredama, vezni materijal između slojeva će se u narednoj fazi opisati mješovitim konstitutivnim zakonom s kohezivnom zonom i oštećenjem. Ovaj tip povezivanja slojeva bit će kasnije primijenjen na sve tipove konstruktivnih modela – ploča, ravnih i zakrivljenih ljuski. Numerički rezultati bit će uspoređeni s rezultatima modela ili eksperimentalnim rezultatima drugih autora iz literature.Istovremeno, neka jednostavna eksperimentalna istraživanja izraditi će se s opremom iz naših laboratorija. U završnoj fazi, izvesti ćemo složene eksperimente na stvarnim modelima s delaminacijom slojeva, te i njih usporediti s odgovarajućim numeričkim modelima.]]></summary_hr><summary_en><![CDATA[We propose a research project in basic technical sciences concerning the numerical analysis of the Mindlin type moderately thick plates and shells by the finite element method.Given our good results in designing quadrilateral and the triangular plate elements (with various number of nodes) by the assumed strain interpolation in the element stiffness formulation, we propose to extend our research to the layered plates in 2D space and the layered facet or curved shells in 3D space. The material connecting the layers will be modeled at first with a simple elastic constitutive law, but following our successful numerical experiments on the layered beams, the interfaces between layers will be further modeled by a mixed-mode cohesive-zone damage-type constitutive law. This kind of interconnection behavior will be then applied to all kinds of structural models - plates, facet and curved shells. The numerical results will be compared with the other models and the experimental results from literature.At the same time, experimental research will be performed using the equipment in our laboratories. We shall try to perform experiments with delamination of the real layered models and also compare them with the appropriate numerical models.]]></summary_en></project><project>
<id>8106</id><title_hr><![CDATA[Procjena atmosverskog taloženja i razine ozona u mediteranskim šumskim ekosustavima]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3501</user_id><user_firstLast_name>Lukrecija Butorac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-5066</code><acronim><![CDATA[DepOMedFor]]></acronim><duration>22.03.2019 - 21.09.2023</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Šumarstvo, </scie_field_hr><scie_field_en>Forestry, </scie_field_en><institution_hr><![CDATA[Institut za jadranske kulture i melioraciju krša]]></institution_hr><institution_en><![CDATA[Institute for Adriatic Crops and Karst Reclamation in Split]]></institution_en><team_members_id>25878</team_members_id><team_members_names><![CDATA[ Doktorand: Ivan Limić ]]></team_members_names><keywords_hr><![CDATA[atmosfersko taloženje, ozon, mediteranski šumski ekosustav, procjena, praćenje]]></keywords_hr><keywords_en><![CDATA[atmospheric deposition, ozone, mediterranean forest ecosystems, assessment, monitoring]]></keywords_en><summary_hr><![CDATA[Šumski ekosustavi se odlikuju izrazito promijenjivim uvjetima za rast i razvoja. Mediteranska regija čini se da je najosjetljivija na globalne promjene i atmosferske utjecaje. Mediteranski šumski ekosustavi su od velike važnosti zbog ekoloških funkcija koje pružaju. Rizik od utjecaja atmosferskih taloženja, erozija, klizišta i poplava je tako visok. Ovi faktori rizika u kombinaciji s klimatskim promjenama  vjerojatno utječu na ciklus nutrienta i hranidbe vrijednosti, vlažnost tla i, u konačnici, na rast i primarnu produktivnosti. Predloženo istraživanje će dati jedinstvenu mogućnost za analizu ne samo biogeokemijskim ciklus elemenata, na lokalnoj razini, nego i procjenu utjecaja onečišćenja na dijelove šumskog ekosusstava, te tijek od izvora do receptora. Da bi ostvarili ciljeve projekta uspostavit će se plohe za praćenje atmosferskih taloženje i razine ozonski na kojima će se vršti mjerenja mjeriti zajedno drugim varijablama, uključujući one koji se odnose na tlo i lišće te hranjiva, zdravstveni satus stabla, rast i stanje krošnje u kombinaciji s meteorološkim podacima. Mi ćemo dobiti potpuno nove, ali potrebne informacije koje nedostaju o atmosferskom taloženju, statusu hranjivih tvari, stvarnim opterećenjima, razini ozona i njegovih učinaka na šumama. Dodane vrijednosti ovog istraživanja će biti ispunjavanja praznina u znanju o naših mediteranskim šumskim ekosustavima i nadogradnju stečenog znanja s različitim statističkim metodama i budućih predviđanja kako bi se procijenilo stanje mediteranskih šumskih ekosustava. Rezultata ovog istraživanja i suradnje s talijanskim i francuski znanstvenim institucijama doprinijeti će široj osvrtu na utjecaje atmosferilija na mediteranske šumske ekosustave istočne obale Jadrana na regionalnoj i Europskoj razini.]]></summary_hr><summary_en><![CDATA[Forest ecosystems are characterized by strongly ?uctuating conditions for tree growth and development. The Mediterranean region appears to be the most vulnerable to global change and atmospheric inputs. Mediterranean forest ecosystems are of very high significance because of ecological functions they provide. The risk of impacts of atmospheric inputs, erosion, landslides and floods is being so high in this region. These risk factors combined with climate change is likely to affect nutrient turnover and nutrient availability, soil moisture and, ultimately, growth and primary productivity. The proposed research will give the unique possibility to analyse not only the biogeochemical cycle of elements, at local scale, but also the assessment of the environmental impact of pollutants on forest ecosystems compartments, following the uptake and the fate, from the sources to the receptors. In order to accomplish project objectives the monitoring plots will be established and atmospheric deposition and ozone levels will be measured together with a suite of other variables including those related to soil and foliar nutrient, tree health, growth and crown condition combined with meteorological data. We will get completely new but necessary missing information on atmospheric deposition, nutrient status, actual loads and ozone levels and its effects on forests. The added values of this research will be filling the gap in knowledge of our Mediterranean forest ecosystems and upgrading the gained knowledge with different statistical methods and future predictions in order to assess the condition of Mediterranean forest ecosystems.The results of this research and collaboration with Italian and French scientific institutions will contribute to the wider overview on impacts of atmospheric inputs in Mediterranean forests ecosystem of Eastern Adriatic coast at the regional and European level.]]></summary_en></project><project>
<id>8107</id><title_hr><![CDATA[Rogozničko morsko jezero kao model odziva ekosustava na promjene u okolišu]]></title_hr><title_en><![CDATA[]]></title_en><user_id>287</user_id><user_firstLast_name>Irena  Ciglenečki-Jušić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-7344</code><acronim><![CDATA[MARRES]]></acronim><duration>06.03.2019 - 27.10.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Interdisciplinarne prirodne znanosti, </scie_field_hr><scie_field_en>Interdisciplinary natural sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>25748</team_members_id><team_members_names><![CDATA[ Doktorand: Sarah Mateša ]]></team_members_names><keywords_hr><![CDATA[Rogozničko jezero,  specijacija i dinamika S spojeva,biogeokemijski procesi, unos iz atmosfere,  radionuklidi ]]></keywords_hr><keywords_en><![CDATA[Rogoznica lake, S speciation and dynamics, biogeochemical processes, atmospheric input, radionuclides]]></keywords_en><summary_hr><![CDATA[MARRES, nastavak SPHERE projekta, ima za cilj koristiti jedinstveni okoliš Rogozničkog jezera kao primjer  ugroženog morskog sustava koji odražava sve hidrografske i atmosferske uvjete Jadranskog mora. U okviru MARRES-a  Rogozničko jezero biti će model za praćenje i karakterizaciju biogeokemijskih procesa kruženja sumpora i ugljika na različitim redoks granicama faza, odnosno pri različitim okolišnim uvjetima. Znanstvenu misiju MARRES će postići suvremenim laboratorijskim tehnikama i radom na terenu, objedinjenim u jedinstveno biogeokemijsko istraživanje. Važan dio projekta biti će usmjeren na transport i izmjenu između atmosfere, vodenog stupca i sedimenta jezera, mjerenjem unosa sumpornih spojeva, organske tvari, radionuklida, nutrijenata i tragova metala mokrim taloženjem iz kiše. Ovisno o specifičnim fizičko-kemijskim uvjetima  pratiti će se i diskutirati ekologija mikroorganizama, fito- i zoo-planktona, te bentosa. Analiza i rasprava novih i dugoročnih podataka ekološkog  statusa jezera, osnovni je preduvjet za razvoj biogeokemijskog modela. Osim Rogozničkog jezera, drugi sustav za praćenje promjena u okolišu povezanih s eutrofikacijom, biti će sjeverni Jadran kao primjer poluzatvorenog, plitkog i potencijalno eutrofnog morskog bazena s povremenim pojavama pridnene anoksije. Istraživanja MARRESa planirana su na vremenskoj skali  od 4 godine, a dobiveni rezultati će značajno pridonijeti općem znanju o stanju i odgovorima istraživanih ekosustava na promjene fizikalnih, kemijskih i bioloških uvjeta uslijed prirodnih i antropogenih, odnosno globalnih promjena u okolišu. Gore navedeni istraživački ciljevi, posebice oni vezani za mobilizaciju ljudskih, tehničkih i infrastrukturnih kapaciteta IRB-a, kao i uključenih partnerskih institucija, usko su usklađeni sa strateškim prioritetima i promicanjem hrvatske znanosti, znanja i iskustva na svjetskom znanstvenom tržištu.]]></summary_hr><summary_en><![CDATA[MARRES, the continuation of the SPHERE project, aims to put in focus Rogoznica lake as an unique example of the threatened marine ecosystems, which feels hydrographic and atmospheric conditions of the Adriatic Sea. Rogoznica lake will be a model for monitoring and characterization of biogeochemical processes related to sulfur and carbon cycling at different redox boundaries under different environmental conditions. The project will achieve scientific mission by state-of-the art laboratory studies and field monitoring integrated in an unique biogeochemical research. Discussion and synthesis of new and long term data of the Lake’s ecological status is fundamental for development of biogeochemical model. An important part of the project will be focused on the exchange and transport between atmosphere, water column and sediment by measuring the atmospheric input (wet deposition) of sulfur compounds (organic and inorganic), organic carbon, radionuclides (Be-7, Pb-210), nutrients and trace metals. Additionally, the ecology of the microorganisms, phyto-  and zoo-plankton, bentos will be correlated with specific lake water physico-chemical conditions. The northern Adriatic as a semi closed, shallow and potentially eutrophic marine basin with occasional appearance of bottom anoxia will be used as another system for tracking environmental changes related to eutrophication. The MARRES is planned for the period of 4 years, and its result will contribute substantially to the improvement of the knowledge on the studied ecosystems responses to likely changes of physical, chemical and biological conditions affected by natural and anthropogenic i.e. global environmental change. Research objectives listed above, especially those related to mobilization of human, technical, and infrastructural capacities of the RBI and involved partner Institutions  are closely in line with strategic priorities and promotion of Croatian science, knowledge and experience on the world science market.]]></summary_en></project><project>
<id>8108</id><title_hr><![CDATA[Provedba vrhunskih istraživanja u sklopu Znanstvenog centra izvrsnosti za kvantne i kompleksne sustave te reprezentacije Liejevih algebri]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6276</user_id><user_firstLast_name>Nenad Pavin</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-5506</code><acronim><![CDATA[]]></acronim><duration>01.03.2019 - 31.08.2023</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>25723</team_members_id><team_members_names><![CDATA[ Doktorand: Arian Ivec ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>8109</id><title_hr><![CDATA[Primjena NGS metoda u procjeni genomske varijabilnosti preživača]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6650</user_id><user_firstLast_name>Ino Čurik</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-6777</code><acronim><![CDATA[ANAGRAMS]]></acronim><duration>23.09.2021 - 22.07.2024</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Agronomski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Agriculture]]></institution_en><team_members_id>865128</team_members_id><team_members_names><![CDATA[ Doktorand: Mario Shihabi ]]></team_members_names><keywords_hr><![CDATA[arheogenetika, konzervacijska genetika, bioraznolikost, genomika, domaće životinje]]></keywords_hr><keywords_en><![CDATA[archaeogenetics, conservation genetics, biodiversity, genomics, livestock]]></keywords_en><summary_hr><![CDATA[Izuzetno brz razvoj metode slijedeće-generacije sekvenciranja (NGS) i računalnih kapaciteta otvorili su nove mogućnosti u različitim znanstvenim područjima (humanoj i veterinarskoj medicini, poljoprivredi, šumarstvu, ekologiji, računalnoj znanosti, pa čak i arheologiji). Uspješna primjena NGS-a i njegova upotreba u različitim discplinama snažno ovisi o stručnosti na nekoliko područja. Ovdje smo okupili stručnjake iz molekularne genetike, populacijske genomike, uzgoja životinja, računalnih znanosti i arheologije kako bismo odgovorili na nekoliko tema vezanih uz konzervacijsku genomiku (efektivnu veličinu populacije, inbreeding i štetno opterećenje genoma) i genomsku biološku raznolikost (izmješanost i poulacijska struktura) preživača. Također ćemo analizirati drevne kosti (>3000 godina) goveđih, kozjih i ovčjih jedinki kako bismo poboljšali naše razumijevanje genomskih promjena u postupku domestikacije (filogeneza mitogenoma). Naš projektni prijedlog ima snažnu komponentu teorijskih dostignuća za procjenu inbreedinga, efektivne veličine populacije i pojedinačnog umješavanja analiziranih računalnim simulacijama (sve oponašaju sekvence). Osim toga, NGS analiza (visoko propusni SNP beadchip i sekvence cijelkupnog genoma) izvoditi će se na nekoliko autohtonih pasmina (goveda, koza i ovaca) sa slijedećim ciljevima; (i) osigurati “genomsko pozicioniranje” hrvatskih pasmina među ostalim svjetskim pasminama, (ii) pružiti procjenu statusa konzervacije hrvatskih pasmina (razina inbreedinga, veličinu efektivne populacije, štetno opterećenje i genetsku raznolikost) i (iii) identificirati genomsku jedinstvenost (genomske regije) koje su specifične za hrvatske autohtone pasmine. Dobiveni rezultati pružit će temelj za buduće upravljanje očuvanjem pasmina. Primjena NGS-a ima snažan potencijalni ekonomski učinak na društvo u budućnosti. Zbog toga ćemo organizrati otvoreni tečaj “Genomika za zaštitu životinja”, napisat nekoliko popularizirajućih članaka i educirati doktorande.]]></summary_hr><summary_en><![CDATA[The extremely fast developments of next-generation-sequencing (NGS) and computer capacity have opened a large number of new possibilities in diverse scientific areas (human and veterinary medicine, agriculture, forestry, ecology, computer science and even archaeology). Unfortunately, successful application of NGS and its application in diverse disciplines is strongly depended on the expertise in several fields. Here we gathered experts from molecular genetics, population genomics, animal breeding, computer science and archaeology to address several topics related to conservation genomics (effective population size, inbreeding and detrimental load) and genomic biodiversity (admixture and population structure) of ruminants. We will also analyse ancient bones (>3000 years) belonging to bovine, caprine and ovine individuals in order to improve our understanding of genomic changes in the domestication process (mitogenome phylogenetics). Our proposal has strong component of theoretical developments for estimation of inbreeding, effective population size and individual admixture analysed by computer simulations (all imitating sequence data). In addition, NGS analyses (high-throughput SNP beadchip and whole genome sequencing) will be performed on several autochthonous breeds (cattle, goat and sheep) with following aims; (i) to provide &#39;&#39;genomic positioning&#39;&#39; of Croatian breeds among other world breeds, (ii) to provide estimates of the conservation status of Croatian (inbreeding level, effective population size, admixture, detrimental load, genetic diversity) and (iii) to identify genomic uniqueness (genomic regions) that are specific for Croatian autochthonous breeds. Results obtained will provide basis for their future conservation management. Application of NGS has strong potential economic impact on the society in future. For that reason, we will organise open course &#39;&#39;Livestock Conservation Genomics&#39;&#39;, write several popularisation articles and train two PhD students.]]></summary_en></project><project>
<id>8110</id><title_hr><![CDATA[Jačanje kapaciteta CerVirVaca za istraživanja u virusnoj imunologiji i vakcinologiji]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4941</user_id><user_firstLast_name>Tihana Lenac Roviš</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-6543</code><acronim><![CDATA[]]></acronim><duration>01.04.2019 - 01.04.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Medicine]]></institution_en><team_members_id>28660</team_members_id><team_members_names><![CDATA[ Doktorand: Dubravka Karner ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>8111</id><title_hr><![CDATA[Kolektivni efekti, tunelirajući i topološki transport u novim nanospojevima]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6910</user_id><user_firstLast_name>Danko Radić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-5329</code><acronim><![CDATA[C3TiNN]]></acronim><duration>01.03.2019 - 30.06.2023</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>25070</team_members_id><team_members_names><![CDATA[ Doktorand: Petra Grozić ]]></team_members_names><keywords_hr><![CDATA[magnetsko polje, magnetski proboj, sintetičko baždarno polje, val gustoće, kvantne oscilacije, NEMS, tunelirajući transport, topološki transport]]></keywords_hr><keywords_en><![CDATA[magnetic field, magnetic breakdown, synthetic gauge field, density wave, quantum oscillations, NEMS, tunneling transport, topological transport]]></keywords_en><summary_hr><![CDATA[Prvi cilj ovog projekta je formulirati teorijski pristup za istraživanje novih značajki pod utjecajem magnetskog polja i drugih baždarnih polja, induciranim npr. deformacijom rešetke, na kolektivna, strukturna, magnetotransportna i elektromehanička svojstava materijala reducirane dimenzije, odnosno 2D i kvazi-2D sustava poput grafena, spojeva baziranih na grafenu i nekih hi-Tc kuprata. Želimo istražiti posebnu ulogu magnetskog proboja u grafenu i sličnim sustavima u kojima elektron-elektron interakcija nije naglašena &#39;&#39;ugnježđenjem&#39;&#39; Fermijeve plohe. Također, u posebnom fokusu je jedinstveno svojstvo grafenskog sustava s Dirakovskom elektronskom disperzijom: nastank snažnih pseudomagnetskih polja zbog mehaničke deformacije rešetke. Naše preliminarne estimacije ukazuju mogućnost nastanka novog tipa osnovnog stanja - val gustoće induciran magnetskim probojem zbog sinttičkog magnetskog polja što možda objašnjava opaženi vala gustoće naboja u interkaliranom grafitu CaC6. Također, želimo istražiti pojavu kvantnih oscilacija u magnetotransportu, fundamentalno utjecanih magnetskim probojem, opaženih u grafenskim sustavima i hi-Tc kupratima. Nadalje, istražit ćemo nanoelektromehanički sustav baziran na grafenu i &#39;&#39;spin-gate&#39;&#39; mehanizmu u cilju nalaženja parametarskog prostora za nastanak samo-ekscitiranih oscilacija zbog magnetomotornog vezanja elektronskog i mehaničkog podsustava uz poseban fokus na ulogu sintetičkih polja. Drugi cilj je eksperimentalna realizacija tj. dizajn i fabrikacija uređaja na nanoskali koji se temelji na spinskim efektima induciranim magnetskim poljem. Također, istražit ćemo nova kolektivna stanja kombiniranjem materijala s različitim parametrima uređenja ili topološki zaštićenim stanjima. Pored fabrikacije obavit ćemo mjerenje kompletne magnetotransportne karakteristike.]]></summary_hr><summary_en><![CDATA[The first goal of this project is to formulate a theoretical approach for novel features under influence of magnetic field and other gauge fields, introduced by e.g. deformation of the lattice, on collective, structural, magneto-transport and electromechanical properties of materials with reduced dimension, namely of 2D and quasi-2D systems like graphene, graphene-based compounds and some high-Tc cuprates. We want to address the special role of magnetic breakdown to collective properties in the graphene-like systems in which electron-electron interaction is not enhanced by the &#39;&#39;nesting&#39;&#39; of the Fermi surface. Also we put a special focus on unique feature of grapehene-like system with Dirac-like electron dispersion: the onset of strong pseudomagnetic fields due to mechanical deformation of lattice. Our preliminary estimations indicate the possibility of new type of ground state - magnetic breakdown-induced density wave, driven by the synthetic magnetic field, possibly explaining the recently observed charge density wave in intercalated graphite CaC6. Also, we want to address the onset of quantum oscillations in magnetotransport, also fundamentally influenced by magnetic breakdown, observed in graphene-based systems and high-Tc cuprates. Furthermore, the graphene-based nanoelectromechanical systems based on spin-gate mechanism will be investigated in order to find parameter space for onset of self-excited oscillations due to magnetomotive coupling of electronic and mechanical subsystem with special focus on the role od synthetic fields. The second goal is experimental realization i.e. design and fabrication of nanoscale devices that utilize and investigate the magnetic field-driven spin-dependent phenomena. We will also explore creating novel collective states by combining materials with different order parameters or topologically protected states. Besides fabrication the complete magnetotransport characteristic will be measured.]]></summary_en></project><project>
<id>8112</id><title_hr><![CDATA[Utjecaj različitih vinifikacijskih tehnologija na kvalitativna svojstva vina od autohtonih hrvatskih sorti: uloga vina u ljudskoj prehrani]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6511</user_id><user_firstLast_name>Sanja Radeka</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-5004</code><acronim><![CDATA[VINUM SANUM]]></acronim><duration>09.01.2019 - 10.03.2023</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Institut za poljoprivredu i turizam]]></institution_hr><institution_en><![CDATA[Institute of Agriculture and Tourism in Poreč]]></institution_en><team_members_id>25498</team_members_id><team_members_names><![CDATA[ Doktorand: Sara Rossi  ]]></team_members_names><keywords_hr><![CDATA[vino, vinifikacijske tehnologije, polifenoli, antioksidanti, ljudsko zdravlje]]></keywords_hr><keywords_en><![CDATA[wine, vinification technology, polyphenols, antioxidants, human health]]></keywords_en><summary_hr><![CDATA[Postoji veliki nedostatak objektivnih spoznaja o utjecaju primjene različitih vinifikacijskih tehnologija na kvalitativna svojstva vina od hrvatskih autohtonih bijelih  crnih sorti vinove loze, te njihove uloge u ljudskoj prehrani. Cilj ovog projekta je utvrditi razlike između kvalitativnih svojstava mladih (svježih) i zrelih (odležalih) vina gospodarski najvažnijih hrvatskih autohtonih bijelih i crnih sorti vinove loze (Malvazija istarska, Teran, Pošip i Plavac mali), proizvedenih različitim tehnologijama vinifikacije (kao što su standardna „brza prerada“ bez maceracije masulja, sa dodatkom i bez dodatka enoloških tanina, kratkotrajna, predfermentativna (crio) maceracija, dugotrajna, postfermentativna maceracija masulja i odležavanje vina u drvenim bačvama), te utjecaj njihove umjerene, kontrolirane konzumacije na psiho-fizičko zdravlje skupina ispitanika uključenih u istraživanje. Proizvedena vina biti će podvrgnuta detaljnoj analizi osnovnog fizikalno-kemijskog sastava, sastava hlapljivih armatskih spojeva, fenolnih spojeva, antioksidacijskog potencijala i nutritivnih svojstva, te će vina biti i senzorno ocjenjena. Posebna pozornost posvetit će se istraživanju spojeva zaslužnih za biološku aktivnost vina i njegovu pozitivnu ulogu u ljudskoj prehrani. Skupine ispitanika uklučene u istraživanje biti će podvrgnute kontroliranoj umjerenoj konzumaciji bijelih i crnih vina, proizvedenih specifičnim tehnologijama, u trajanju od 1-3 mjeseca, te će im se redovito kontrolirati zdravstveni parametri (tlak, šećer, kolesterol LDL, HDL, hormoni „sreće“ itd.). Također ispitanici će biti anketirani, prema unaprijed razrađenim anketnim upitnicima, o razini raspoloženja prije i nakon umjerene konzumacije vina. ]]></summary_hr><summary_en><![CDATA[There is a great lack of objective knowledge of the influence of the use of different vinification technologies on the qualitative properties of wines produced from Croatian autochthonous white grape varieties of vines and their role in human nutrition. The aim of this project is to determine the differences between the qualitative characteristics of young (fresh) and mature (aged) wines of the most important Croatian autochthonous white and black grape varieties (Malvazija istarska, Teran, Pošip and Plavac mali) produced by various vinification technologies (such as standard &#39;&#39;rapid processing&#39;&#39; without maceration of the grape mash, with addition and without the addition of oenological tannins, short-term pre-fermentation (cryo) maceration, long-lasting, post fermentative maceration and maturation of wine in wooden barrels), and the influence of moderate, controlled consumption of wine on the psychophysical health of surveyed groups. Produced wines will be subjected to a detailed analysis of the basic physical-chemical composition, volatile compounds, phenolic compounds, antioxidant potential and nutritional properties, and the wines will be sensoricaly evaluated. Particular attention will be paid to the research of compounds responsible for the bioactivity of wine and its positive role in human diet. The groups of participants surveyed will be subjected to controlled moderate consumption of white and black wines produced by specific technologies for 1-3 months and human health parameters will be regularly monitored (blood pressure, sugar, LDL cholesterol, HDL, &#39;&#39;happiness hormones&#39;&#39;, etc.). Also, participants will be interviewed, according to pre-elaborated questionnaires, about the psychological state before and after moderate consumption of wine.]]></summary_en></project><project>
<id>8113</id><title_hr><![CDATA[Molekularno prepoznavanje DNA:RNA hibridnih i višelančanih struktura u bioanalitičkim i in vitro sustavima]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1214</user_id><user_firstLast_name>Marijana Radić Stojković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-2741</code><acronim><![CDATA[DNARNAHyB-MolBio]]></acronim><duration>08.05.2019 - 07.09.2023</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>26556</team_members_id><team_members_names><![CDATA[ Doktorand: Iva Zonjić ]]></team_members_names><keywords_hr><![CDATA[DNA:RNA hibridne i višelančane strukture, molekularno prepoznavanje, metode visoke propusnosti, potencijal vezanja, antproliferativna aktivnost]]></keywords_hr><keywords_en><![CDATA[DNA:RNA hybrid and multistranded structures, molecular recognition, high-throughput methods, binding potential, antiproliferative activity]]></keywords_en><summary_hr><![CDATA[DNA:RNA hibridne i višelančane strukture stvaraju se kao prijelazne strukture tijekom mnogih biološki važnih procesa ako što su replikacija DNA, transkripcija, replikacija telomera i virusa HIV. Stoga predstavljaju atraktivne mete za male molekule osobito zato što nema puno literaturnih izvora koji navode ligande sa selektivnim vezanjem na te mete. Za ispunjavanje glavnog cilja projekta, potraga za novim strukturnim motivima/spojevima sa preferencijalnim vezanjem na DNA:RNA hibridne i višelančane strukture u odnosu na regularne DNA i RNA dvolančane i jednolančane strukture, prvo moraju biti ispunjeni drugi ciljevi: formiranje biblioteke spojeva sa strukturnim motivom potrebnim za prepoznavanje ovih meta, uvođenje i primjena novih DNA i RNA meta (DNA:RNA hibridne i višelančane strukture) i metoda visoke propusnosti  (kompeticijska dijaliza, temperaturno mekšanje smjesa, RNaseH test) u područje istraživanja projektnog tima, koje bi omogućile brzi probir spojeva sa sposobnošću prepoznavanja tih meta. Slijedeći cilj je detaljno istražiti način vezanja izabranih kompleksa ligand-DNA/RNA u bioanalitičkim sustavima (vodene puferirane otopine) pomoću spektroskopskih, kalorimetrijskih i komputacijskih metoda. Istražiti ćemo također moguću korelaciju između visokog veznog potencijala izabranih spojeva i antiproliferativne aktivnosti u kulturi stanica (MTT, protočna citometrija, konfokalna mikroskopija). Očekivani rezultati, ispunjavanje gore navedenih ciljeva, mogu se iskoristiti za: proširivanje osnovnog znanja u ovom području istraživanja, optimizaciju strukture spojeva s ciljem poboljšavanja njihove selektivnosti vezanja prema željenim DNA i RNA metama, moguću medicinsku primjenu, jačanje međuinstitucijske suradnje u Hrvatskoj i razvoj novih znanstvenih ekspertiza što će nama i našim suradnicima omogućiti publiciranje u časopisima visoke kvalitete.]]></summary_hr><summary_en><![CDATA[DNA:RNA hybrid and multistranded structures are formed as intermediate structures during many biologically important processes such as DNA replication, transcription, telomere replication and replication of HIV virus. Therefore, they represent attractive targets for small molecules, especially since the literature citations of the ligands with selective binding to these targets are scarce. To fulfill the main project goal, the search for new structural motives/compounds with preferential binding to DNA:RNA hybrid and multistranded structures vs. regular DNA and RNA duplexes and single-stranded structures, other aims have to be fulfilled first: forming a library of compounds, with structural motif necessary for interaction with these targets, introduction and implementation of new DNA and RNA targets (DNA:RNA hybrid and multistranded structures) and high-throughput methods (competition dialysis, thermal denaturation of mixtures, RNaseH assay) in the research study of our project team, which would enable fast screening of compounds for recognition of these targets. Another aim is to investigate in detail the mode of binding of selected ligand-DNA/RNA complexes in bioanalytical systems (aqueous buffered solutions) by spectroscopic, calorimetric and computational methods. Further, we will investigate the possible correlation between the strong binding potential of selected compounds and their antiproliferative activity in cell culture (MTT, flow cytometry, confocal microscopy).Expected results, fulfillment of the above-mentioned aims can be utilized for: broadening of the basic knowledge in the research area, optimisation of the ligands structure with the goal of improving the binding selectivity to desired DNA and RNA targets, possible medicinal use, strengthening of the inter-organizational collaboration in Croatia and development of novel research expertise that would enable publishing in quality scientific journals.]]></summary_en></project><project>
<id>8114</id><title_hr><![CDATA[Patogeneza citomegalovirusne infekcije u jajnicima, utjecaj na plodnost i održavanje trudnoće]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4682</user_id><user_firstLast_name>Vanda Juranić Lisnić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-9349</code><acronim><![CDATA[JaPI]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Medicine]]></institution_en><team_members_id>28629</team_members_id><team_members_names><![CDATA[ Doktorand: Ana Vrbanović Vrbanović ]]></team_members_names><keywords_hr><![CDATA[citomegalovirus, plodnost, jajnici, trudnoća, progesteron, infekcija, patogeneza, pobačaj]]></keywords_hr><keywords_en><![CDATA[cytomegalovirus, fertility, ovaries, pregnancy, progesterone, infection, pathogenesis, pregnancy-loss]]></keywords_en><summary_hr><![CDATA[Humani citomegalovirus (HCMV) je herpes virus kojim je zaražena većina svjetske populacije. Infekcija HCMV-om opasna je u trudnica: može izazvati pobačaj ili brojne trajne malformacije ploda. Efikasno cjepivo ne postoji, a dostupni lijekovi imaju brojne nuspojave. Infekcija miševa mišjim CMV-om najčešće je korišteni model kojim se istražuje biologija i patogeneza HCMV-a. U našem dosadašnjem radu primijetili smo da MCMV vrlo uspješno inficira jajnike spolno zrelih ženki miševa. Detaljnijom analizom ustanovili smo da je infekcija ograničena na žuta tijela i stromu jajnika. Folikuli, strukture u kojima se čuva jajna stanica do trenutka ovulacije, nisu bili inficirani. Čak i kod infekcije imunosuprimiranog mišjeg soja IFNgamma KO koji slabo kontrolira virus, folikuli su većinom ostali neinficirani unatoč izuzetno snažnoj infekciji žutih tijela i strome. Infekcija žutih tijela može ugroziti trudnoću, a infekcija folikula ugrožava cjelokupni fertilitet jedinke te je razumijevanje mehanizama kojima se folikuli brane od infekcije od izuzetne važnosti. Naša preliminarna istraživanja pokazuju da se folikularne stanice mogu inficirati ex vivo; stoga predlažemo istraživanja kojima bi se utvrdili morfološki i imunološki faktori koji brane folikule od infekcija u jajniku. Razumijevanje mehanizama kojima se folikuli brane od infekcije prirodnim patogenom pomoći će nam u rasvjetljavanju nekih uzroka neplodnosti.Žuta tijela glavni su proizvođači hormona progesterona koji je neophodan za održavanje trudnoće, posebno rane. Naša preliminarna istraživanja pokazuju da infekcija jajnika MCMV-om značajno smanjuje razinu progesterona te bi tako mogla dovesti do pobačaja. Stoga ćemo istražiti mehanizme koji dovode do smanjenja razina progesterona  kao i potencijalni terapeutski učinak davanja progesterona zaraženim trudnim ženkama.Zaključno, predloženo istraživanje predstavlja važan korak ka razumijevanju utjecaja infekcije izuzetno učestalim patogenom na reproduktivno zdravlje.]]></summary_hr><summary_en><![CDATA[Human cytomegalovirus (HCMV) is a herpes virus that infects the majority of world’s population. Infection during pregnancy can lead to pregnancy-loss or numerous developmental disabilities of the fetus. There is no effective vaccine while available treatments have numerous side-effects.Murine CMV infection of mice is the most commonly used model to study the biology and pathogenesis of HCMV. We observed strong infection of the ovaries of sexually mature female mice, in stroma and corpora lutea. Interestingly, the infection was excluded from the ovarian follicles, structures that contain oocytes. Even when very immunosuppressed mouse strain IFNgamma KO was infected, follicles mostly remained uninfected despite nearly complete infection of corpora lutea and stroma. Infection of corpora lutea may endanger ongoing pregnancy while infection of follicles threatens whole reproductive capacity. Therefore, better understanding of mechanisms that protect follicles from naturally occurring infections is of utmost importance. Since our preliminary results show that follicular cells can be infected ex vivo, we propose to investigate morphological and immunological factors that protect the follicles. Understanding the mechanisms that protect the follicles during infection with a natural and pervasive pathogen may help in uncovering etiology of infertility. Corpora lutea are the main producers of progesterone, hormone essential for pregnancy maintenance, especially early. Our preliminary data shows that MCMV infection of ovaries results in significant downregulation of serum progesterone levels which could cause abortions. We therefore wish to investigate the mechanisms behind this downregulation and therapeutic application of exogenous progesterone treatment.In conclusion, the proposed research is an important step in understanding the impact of naturally occurring pervasive pathogen on reproductive health.]]></summary_en></project><project>
<id>8116</id><title_hr><![CDATA[Marine robotics research infrastructure network (EUMarineRobots)]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5962</user_id><user_firstLast_name>Nikola Mišković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-9219</code><acronim><![CDATA[]]></acronim><duration>01.02.2021 - 30.11.2023</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>865288</team_members_id><team_members_names><![CDATA[ Doktorand: Fran Penić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>8117</id><title_hr><![CDATA[OLEUM – Advanced solution for assuring the overall authenticity and quality of olive oil]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5679</user_id><user_firstLast_name>Karolina Brkić Bubola</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-2293</code><acronim><![CDATA[]]></acronim><duration>20.12.2018 - 21.03.2023</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Prehrambena tehnologija, </scie_field_hr><scie_field_en>Food technology, </scie_field_en><institution_hr><![CDATA[Institut za poljoprivredu i turizam]]></institution_hr><institution_en><![CDATA[Institute of Agriculture and Tourism in Poreč]]></institution_en><team_members_id>25430</team_members_id><team_members_names><![CDATA[ Doktorand: Dora Klisović ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>8118</id><title_hr><![CDATA[Matične stanice usne šupljine čovjeka za liječenje ishemijske bolesti mozga]]></title_hr><title_en><![CDATA[]]></title_en><user_id>12653</user_id><user_firstLast_name>Dinko Mitrečić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-8773</code><acronim><![CDATA[ORASTEM]]></acronim><duration>06.05.2019 - 06.11.2023</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>28671</team_members_id><team_members_names><![CDATA[ Doktorand: Denis Jagečić ]]></team_members_names><keywords_hr><![CDATA[moždani udar, matične stanice, sluznica usne šupljine, regenerativna medicina, transkriptom ]]></keywords_hr><keywords_en><![CDATA[stroke, stem cells, oral mucosa, regenerative medicine, transriptome]]></keywords_en><summary_hr><![CDATA[Ishemijska ozljeda mozga je najčešći oblik moždanog udara te predstavlja jedan od najvećih medicinskih problema čovječanstva. U ovom projektu ćemo po prvi put istražiti terapijski potencijal nedavno otkrivenih ektodermalnih matičnih stanica ljudske sluznice usne šupljine (SOS) na modelu ishemije mozga miša. U preliminarnim pokusima smo pokazali da se ove stanice lako dobivaju iz sluznice usne šupljine pacijenta, a zbog svojeg ektodermalnog podrijetla daju živčane i glija stanice. Nakon dobivanja stanica u suradnji sa Stomatološkim fakultetom u Zagrebu, analizirat ćemo njihovo umnažanje, diferencijacijski potencijal i preživljenje tijekom rasta in vitro. Biljege diferencijacije ćemo analizirati RT-PCRom i imunohistokemijom u periodu od 14 dana, a rezultati dobiveni u normalnim uvjetima će se usporediti sa onima u uvjetima hipoksije. Razlike u odgovoru stanica na ishemiju će biti analizirane na razini transkriptoma koja će biti učinjena u suradnji s New York University Abu Dhabi. U idućoj grupi pokusa ćemo transplantirati SOS u mišji model moždanog udara. U dvije vremenske točke, 7 i 30 dana nakon transplantacije ćemo opisati njihovo preživljenje, migraciju i diferencijaciju. Miševi tretirani mišjim živčanim matičnm stanicama, ljudskim stanicama sluznice usne šupljine te netretirani miševi će biti uspoređeni - oslikani na magnetnoj rezonanci (Bruker 7T) i praćeni u nizu testova zdravstvenog statusa. Na taj način ćemo zaključiti o brzini njihovog oporavka. Očekujemo da će matične stanice usne šupljine čovjeka zbog svojeg podrijetla, pozitivnih rezultata na modelima neurodegeneracije i ozljede te naših preliminarnih rezultata pokazati visok potencijal za liječenje ishemijske bolesti mozga. Ukoliko se naša hipoteza potvrdi, ove će stanice zbog svoje dostupnosti, ektodermalnog podrijetla i terapijskog potencijala biti predložene kao stanice prvog izbora u kliničkim pokusima na pacijentima oboljelima od moždanog udara. ]]></summary_hr><summary_en><![CDATA[Ischemic brain damage is the most common form of stroke and represents one of the largest medical problems of the human society. In this project we will, for the first time, analyze therapeutic potential of recently discovered ectodermal stem cells from the oral mucosa (hOMSC) for treatment of brain ischemia. In preliminary experiments we have shown that hOMSC can be easily isolated from the mouth cavity of the patients and because of their origin – they give rise to neurons and glia. After isolation of cells, in collaboration with University of Zagreb School of Dentistry, we will analyze cell proliferation, differentiation potential and survival during cultivation in vitro . We will analyze markers of differentiation by immunhistochemistry and RT PCR in the period of 14 days and results obtained in normal conditions will be compared to in vitro hypoxia. Difference in cell response will be additionally analyzed on the level of transcriptome  which will be performed by New York University Abu Dhabi. In the next group of experiments we will transplant hOMSC in the animal model of stroke. In two time points, 7 and 30 days after transplantation we will describe their survival, migration and differentiation. Mice treated by hOMSC, NSC and untreated group will be tested in standardized tests of mouse Health status and imaged on MRI (Bruker, 7T). This will allow to conclude about histological and functional recovery of tested mice. We expect that, based on their embryonic origin, positive results on animal models of neurodegeneration and nerve damage and our promising preliminary results, hOMSC will exhibit beneficial effects for animals affected by stroke. If our hypothesis will be confirmed, hOMSC will be, because of their easy access, ectodermal origin and therapeutic potential, suggested as the perfect candidate for clinical trials on patients affected by stroke. ]]></summary_en></project><project>
<id>8119</id><title_hr><![CDATA[Određivanje fizikalno-kemijskih svojstava i toksičnosti nanočestica srebra, bakra i plastike kao potencijalno štetnih novih materijala u obalnim vodama]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4961</user_id><user_firstLast_name>Daniel Lyons</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-2123</code><acronim><![CDATA[NANO-EMC2]]></acronim><duration>11.07.2019 - 28.11.2024</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Interdisciplinarne prirodne znanosti, </scie_field_hr><scie_field_en>Interdisciplinary natural sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>28141</team_members_id><team_members_names><![CDATA[ Doktorand: Ivana Hazdovac ]]></team_members_names><keywords_hr><![CDATA[istraživanja mora i ušće rijeke, nanočestica, nanoplastika, kinetika, toksičnost, bioakumulacija, klimatske promjene ]]></keywords_hr><keywords_en><![CDATA[marine and estuarine research, nanoparticle, nanoplastic, kinetics, toxicity, bioaccumulation, climate change]]></keywords_en><summary_hr><![CDATA[Usporedno s rastućom uporabom proizvoda koji sadrže nanočestice, očekuje se značajno povećanje njihovog oslobađanja u okolinu. Mnoga istraživanja vezana za ponašanje i sudbinu umjetno proizvedenih nanočestica (engl. engineered nanoparticles, ENPs) usmjerena su na kopnene vodene sustave (jezera, rijeke i podzemne vode) zbog očekivanja da će se nanočestice oslobođene u okolinu s vremenom razgraditi u tim istim sustavima bez značajnog prijenosa na ostale dijelove okoliša. Međutim, uzimajući u obzir mnoga nastanjena mjesta u obalnim područjima, potencijalno opterećenje velikom količinom nanočestica u ušćima rijeka kao i priobalnim vodama u nadolazećim godinama sve je značajnije. Budući da postoje dokazi da različite nanočestice mogu biti toksične za brojne organizme, posebno osjetljivi bi mogli biti organizmi u ušćima rijeka i u priobalnim područjima. Međutim, dostupne informacije vezane za ponašanje nanočestica u elektrolitima velike ionske jakosti, posebice učinak koji mogu imati njihovi omotači na koloidnu stabilnost, specijaciju i kinetiku, malobrojne su i nedorečene. Nadalje, trenutno postoji veoma malo raspoloživih podataka o međusobnom djelovanju nanočestica s širokim rasponom raznih organizama u bočatoj i obalnoj vodi. Ovaj će projekt istražiti fizikalno-kemijsko ponašanje nanočestica srebra, bakra i polimera/plastike različitih veličina i površinskih omotača, kao potencijalno opasnih materijala u vodenom stupcu bočatih i obalnih voda, uzevši u obzir abiotičke čimbenike kao što su salinitet, pH, koncentracija kisika i otopljena organsku tvar. Standardizirani biokemijski testovi, prilagođeni specifičnim svojstvima i učinku interferencije ENP, koristiti će se za mjerenje širokog raspona indikatora toksičnosti na izabrane organizme od algi i makroalgi do ježinaca, školjkaša i rakova. Ovim projektom omogućit će se po prvi puta cjelokupni pregled ponašanja nanočestica srebra, bakra i plastike u bočatoj vodi kao kompleksnoj zoni prijelaza iz slatkovodne u morsku vodu.]]></summary_hr><summary_en><![CDATA[In parallel with the growing use of nanoparticle-containing products, their release into the environment over the coming years is expected to increase significantly. Much of the research on the behaviour and fate of engineered nanoparticles (ENPs) in the environment has focused on terrestrial aquatic systems (lakes, rivers and groundwater) due to the expectation that ENPs would eventually be degraded in these systems without significant transport to other environmental compartments. However, with many large population centres located in near-coastal areas, the potential environmental load of nanoparticles in estuarine and coastal waters over the coming years is enormous. As there is increasing evidence that various nanoparticles may be toxic to a range of organisms, biota in estuarine and coastal waters may thus be particularly vulnerable. However, available data on how nanoparticles behave in high strength electrolytes, in particular the effect of their coating on colloidal stability, speciation or ion release kinetics are scarce. Further, there is little data on how such aged nanoparticles interact with the wide range of diverse organisms in brackish and coastal waters.This project will investigate the physico-chemical behaviour of silver, copper and polymer/plastic nanoparticles with a range of different sizes and surface coatings, as materials of concern, in brackish and marine waters based on a range of abiotic factors including salinity, pH, oxygen concentration and dissolved organic matter. Standardised biochemical tests, adapted to take into account the specific properties and interference effects of ENPs, will be used to measure a range of toxicity endpoints in selected organisms ranging from algae and macroalgae to urchins, mussels and crabs. The results from this project will provide for the first time a systematic overview of the behaviour of silver, copper and plastic nanoparticles in brackish water as a complex transition zone from fresh to salt water.]]></summary_en></project><project>
<id>8120</id><title_hr><![CDATA[Detaljan uvid u mehanizme polaronske i ionske vodljivosti u oksidnoj staklo-(keramici)]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3297</user_id><user_firstLast_name>Ana Šantić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-5155</code><acronim><![CDATA[POLAR-ION-GLASS]]></acronim><duration>08.05.2019 - 07.09.2023</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>26576</team_members_id><team_members_names><![CDATA[ Doktorand: Sanja Renka ]]></team_members_names><keywords_hr><![CDATA[staklo, staklo-keramika, ionska vodljivost, polaronska vodljivost, struktura]]></keywords_hr><keywords_en><![CDATA[glasses, glass-ceramics, ionic conductivity, polaronic conductivity, structure]]></keywords_en><summary_hr><![CDATA[Električki vodljiva oksidna stakla važni su elektrolitni/elektrodni materijali koji se sve više primijenjuju u modernim elektrokemijskim uređajima. U ovim staklima tip električne vodljivosti (polaronski, ionski ili miješani ionsko-polaronski) ovisi o sastavu stakla, dok utjecaj međudjelovanja nositelja naboja s lokalnim strukturnim okruženjem definira mehanizam transporta. Zbog strukturne neuređenosti i velike raznolikosti strukturnih jedinica razumijevanje električnog transporta na mikroskopskoj skali u staklu predstavlja veliki izazov. Glavni je cilj predloženog projekta razjasniti mehanizme polaronske i ionske vodljivosti u volframsko- i molibdensko-fosfatnim staklima i staklo-keramici s posebnim naglaskom na povezanost sa strukturom. Predloženo istraživanje sastoji se od tri međusobno povezana koraka: 1) određivanje faktora koji određuju polaronsku vodljivost u binarnim volframsko- i molibdensko-fosfatnim staklima, 2) istraživanje miješanog ionsko-polaronskog transporta u volframsko- i molibdensko-fosfatnim staklima koja sadrže alkalijske okside i 3) ispitivanje utjecaja kristalizacije na električni transport u odabranim modelnim staklima iz koraka 1) i 2) s ciljem priprave vodljive staklo-keramike s prilagodljivim doprinosom ionske i polaronske vodljivosti. Odabrani sustavi posebno su atraktivni za primjenu kao katode u krutim baterijama jer fosforov oksid tvori stakla s alkalijskim i prijelaznim metalnim oksidima u širokom koncentracijskom području što omogućava visoku polaronsku i ionsku vodljivost. Detaljna strukturna i električna karakterizacija neophodna za rasvjetljavanje i povezivanje procesa polaronskog i ionskog transporta u ovim materijalima provest će se nizom naprednih komplementarnih metoda (Ramanska, MAS NMR i EPR spektroskopija, neutronska i rendgenska difrakcija, impedancijska spektroskopija, DC mjerenja), a značajan uvid u elementarne procese gibanja polarona i iona dat će numeričko modeliranje električne provodnosti MIGRATION konceptom.]]></summary_hr><summary_en><![CDATA[Electrically conducting oxide glasses are an important class of electrolyte/electrode materials whose application in modern electrochemical devices are growing rapidly. The type of conduction (polaronic, ionic or mixed polaronic-ionic) in these glasses depends on the composition, while the transport mechanism itself is strongly influenced by the interaction of charge carriers with the local structural environment and understanding it from a microscopic point of view poses a major challenge. The overall aim of the proposed project is to clarify the mechanisms of polaronic and ionic conduction in tungsten phosphate and molybdenum phosphate glasses and glass-ceramics with a special emphasis on their correlation to the structure. The proposed research contains three interconnected steps: 1) identification of factors that govern polaronic conduction in binary tungsten/molybdenum phosphate glasses, 2) investigation of the mixed conduction in tungsten/molybdenum phosphate glasses containing alkali oxides and 3) study of the influence of crystallization on electrical transport in selected glasses from steps 1) and 2) in order to obtain highly conductive glass-ceramics with tuneable contributions of polaronic and ionic conduction. The chosen phosphate glasses are especially attractive for application as cathodes in solid-state batteries because they can accommodate a considerable amounts of transition metal and alkali oxides, and hence exhibit high polaronic and ionic conductivity. Detailed structural and electrical characterizations which are needed for resolving and relating processes of polaronic and ionic transport in these materials will be achieved using various advanced methods (Raman, MAS NMR and EPR spectroscopy, neutron and X-ray diffraction, impedance spectroscopy, DC measurements), while the numerical modelling of electrical conductivity using MIGRATION concept will give additional valuable insights into the elementary processes of polaronic and ionic motions.]]></summary_en></project><project>
<id>8122</id><title_hr><![CDATA[HRVATSKI MONITOR NASILJA - Istraživanje pojavnih oblika, uzroka i procesuiranja delinkventnog nasilja s fokusom na zaštiti posebno ranjivih skupina žrtava]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6366</user_id><user_firstLast_name>Goran Livazović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-6175</code><acronim><![CDATA[CroViMo]]></acronim><duration>25.03.2019 - 24.09.2023</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Pedagogija, </scie_field_hr><scie_field_en>Pedagogy, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>23551</team_members_id><team_members_names><![CDATA[ Doktorand: Karlo Bojčić ]]></team_members_names><keywords_hr><![CDATA[kriminologija, nasilje, prevencija nasilja, ubojstvo, kibernetičko uznemiravanje, Hrvatska]]></keywords_hr><keywords_en><![CDATA[criminology, violence, violence prevention, homicide, cyber harassment, Croatia]]></keywords_en><summary_hr><![CDATA[Projekt CroViMo ima za cilj uspostavljanje multidisciplinarne grupe mladih znanstvenika koji će provoditi inovativna istraživanja nasilja u Hrvatskoj kroz svoj „Laboratorij za analizu nasilja“. Glavni cilj istraživanja je empirijsko i normativno snimiti te analizirati fenomenologiju, etiologiju i procesuiranje delinkventnog nasilja u Hrvatskoj, pri čemu će naglasak biti na posebno ranjivim skupinama žrtava sa svojim vrlo specifičnim i različitim potrebama zaštite od nasilja. Te posebno ranjive skupine uključuju: djecu; žene i djevojke; starije; manjine, strance, izbjeglice i migrante; osobe u institucionaliziranoj skrbi; osoblje rizičnih zanimanja; i LGBT. Za razliku od uobičajenog tzv. „mainstream“ istraživanja nasilja, koje se uglavnom fokusira na specifične (pod)vrste nasilja i/ili skupine žrtava izvan općeg konteksta delinkventnog nasilja, CroViMo će prvo provesti izvorno istraživanje ukupnog delinkventnog nasilja, prije no što se fokusira na njegove pojedine (pod)vrste. Ovaj holistički pristup temelji se na pretpostavci da proučavanje određene (pod)vrste nasilja, bez empirijskih podataka o općem nasilnom kontekstu dovodi do fragmentarnih, a potencijalno i iskrivljenih shvaćanja pojedinih promatranih (pod)vrsta nasilja. Glavni zadatak CroViMo biti će razviti i testirati novu inovativnu klasifikaciju delinkventnog nasilja, „autentični sustav klasifikacije nasilja”, koja neće podlijegati normativnim ograničenjima trenutnih klasifikacija, nego će biti usredotočena isključivo na sam fenomen nasilja. Takav sustav klasifikacije mogao bi označiti prekretnicu u području istraživanja nasilja. Ovaj ambiciozni plan rada, ukoliko bi bio uspješno proveden, trebao bi dugoročno osigurati razvoj projekta CroViMo u prepoznatljiv nacionalni, regionalni i europski „Laboratorij za analizu nasilja“, te privući daljnje nacionalne i međunarodne znanstvene suradnje i uspješne nove kolaborativne projektne prijave, s velikim potencijalom za prijenos znanstvenih spoznaja u praksu.]]></summary_hr><summary_en><![CDATA[The CroViMo project aims at setting up a multidisciplinary nationwide research group of young researchers for conducting innovative violence research in Croatia through its&#39; “Violence Research Lab”. The central research objective is to empirically and normatively capture and analyse the phenomenology, etiology, and prosecution of delinquent violence in Croatia, with special focus on particularly vulnerable groups of victims with their very specific and diverse needs for protection from violence. These particularly vulnerable groups include: children; women and girls; the elderly; minorities, foreigners, refugees and migrants; persons in institutional custody; risky professions’ personnel; and LGBT. In contrast to ‘mainstream’ violence research, which predominantly focuses on specific (sub)types of violence and/or victim groups outside the overall context of general delinquent violence, CroViMo will conduct genuine foundational research on the total of delinquent violence, before focusing on its’ certain (sub)types. This broad approach is based on the premise that the study of certain (sub)types of violence without empirical data on the overall violent context leads to fragmentary, and potentially distorted understandings of the (sub)types in question. The main task of CroViMo will be to develop and test an innovative new classification of delinquent violence, the “genuine violence classification system” that will blend out the normative constraints of current mainstream classifications and focus strictly on the violence itself. Such a classification system might be a breakthrough in violence research. This ambitious work plan, if implemented successfully, should in the long run facilitate CroViMo’s development into a recognisable national, regional, and European “Violence Research Lab”, attracting further national and international scientific cooperation and successful joint funding applications, with a huge potential for dissemination of findings into practice.]]></summary_en></project><project>
<id>8123</id><title_hr><![CDATA[Napredna simulacija samoobnavljajućih kompozita]]></title_hr><title_en><![CDATA[]]></title_en><user_id>12906</user_id><user_firstLast_name>Ivica Smojver</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-3954</code><acronim><![CDATA[ACCESS]]></acronim><duration>11.03.2019 - 09.06.2023</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Zrakoplovstvo, raketna i svemirska tehnika, </scie_field_hr><scie_field_en>Aerospace, missile and space engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>28693</team_members_id><team_members_names><![CDATA[ Doktorand: Dominik Brezetić ]]></team_members_names><keywords_hr><![CDATA[Višerazinska analiza, samoobnavljajući materijali, mikromehanika, višeslojni kompoziti, napredne kompozitne konstrukcije]]></keywords_hr><keywords_en><![CDATA[Multiscale analysis, self-healing materials, micromechanics, layered composites, advanced composite structures]]></keywords_en><summary_hr><![CDATA[Predmet istraživanja je razvoj numeričke metodologije za modeliranje naprednih kompozitnih konstrukcija sa samoobnavljanjem mehaničkih svojstava. Istraživanje je usmjereno na nove vrste kompozitnih materijala s mogućnošću samoobnavljanja te će zbog toga razvoj numeričke metodologije biti usko povezan s eksperimentalnim istraživanjem. Princip samoobnavljanja temelji se na pristupu u kojemu je zacjeljivanje (obnavljanje) mehaničkih svojstava inicirano samom pojavom oštećenja u konstrukciji. Ovaj proces može biti unutarnji (autonoman) ili izazvan vanjskim utjecajem (grijanje, ultraljubičasto zračenje ili neka druga vanjska pobuda). Numerička metodologija za kompozitne materijale sa samoobnavljanjem svojstava će se temeljiti na višerazinskim metodama, budući da se načini popuštanja kompozitnih konstrukcija i događaju na različitim razinama. Višerazinski pristup će omogućiti daljnji razvoj konstitutivnih modela, kao i modela mehanike oštećenja i homogenizacije mehaničkih svojstava kompozitnog materijala. Metodologija će biti prilagođena primjeni na materijalnim sustavima samoobnavljanja s ciljem primjene na konstruktivnim elementima budućih konstrukcija.  Stoga se predloženo istraživanje temelji na naprednim analitičkim i polu-analitičkim mikromehaničkim modelima koji su atraktivna alternativa potpuno numeričkim modelima.Razvijena višerazinska metodologija će biti verificirana usporedbom s eksperimentalnim istraživanjem.  Biti će istražena mehanička svojstva i efikasnost zacjeljivanja vlaknima ojačane termoplastične matrice, sa prethodno dokazanim svojstvima samozacjeljivanja. Kompozit uključuje jednousmjerena ugljična vlakna u djelomično neutraliziranom poly(ethylene-co-methacrylic acid) ionomernom kopolimeru, Surlyn 8940 (DuPont). Širi cilj provođenja eksperimenata biti će istraživanje primjene razmatranih samoobnavljaućih materijalnih sustava u potencijalnoj budućoj primjeni u kompozitnim konstrukcijama. ]]></summary_hr><summary_en><![CDATA[The project deals with the development of a numerical methodology for modelling of advanced composite structures with self-healing capabilities. The research is aimed at a novel composite material with intrinsic self-healing capability. Therefore, the development of the numerical procedures will be supported by experimental analyses. Self-healing includes a new paradigm where the healing process is initiated by the damage itself within the mechanical component. The numerical methodology for self-healing composites will be based on multiscale concepts, since the failure modes of composite structures appear at different length scales. Application of the multiscale methodology will enable the further development of constitutive models, as well as damage models and material homogenisation of the composite material, to be applied in self-healing structures with the future final goal of application various structural elements. Therefore, an important aspect of the numerical model is computational efficiency at the micro-scale of the heterogeneous material which will allow structural scale application of the multiscale approach. Consequently, the proposed research is based on advanced analytical and semi-analytical micromechanical models which present an attractive alternative to purely numerical models. The developed multiscale methodology will be validated by comparison with experimental investigation. Mechanical properties and healing efficiency of a fibre reinforced thermoplastic resin with previously proved self-healing properties will be investigated. The composite incorporates uniaxially aligned carbon fibres in a partially neutralised poly(ethylene-co-methacrylic acid) ionomer copolymer, Surlyn 8940 (DuPont). A further objective of the experiments will be to investigate the applicability of the evaluated self-healing material system for a possible future application in composite structures.]]></summary_en></project><project>
<id>8124</id><title_hr><![CDATA[NK stanice u patogenezi kongenitalne infekcije citomegalovirusom]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4652</user_id><user_firstLast_name>Berislav Lisnić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-1193</code><acronim><![CDATA[NKconCMV]]></acronim><duration>01.04.2019 - 31.03.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Medicine]]></institution_en><team_members_id>28652</team_members_id><team_members_names><![CDATA[ Doktorand: Carmen Rožmanić ]]></team_members_names><keywords_hr><![CDATA[citomegalovirus, kongenitalna infekcija, NK stanice, iscrpljenost NK stanica, Eomes]]></keywords_hr><keywords_en><![CDATA[cytomegalovirus, congenital infection, NK cells, NK cell exhaustion, Eomes]]></keywords_en><summary_hr><![CDATA[Kongenitalna infekcija humanim citomegalovirusom (HCMV) najčešći je virusni uzročnik razvojnih i funkcijskih poremećaja živčanog sustava, kao što su mentalna retardacija, mikrocefalija i senzori neuralnog oštećenja sluha. S obzirom da je HCMV specifičan za vrstu u istraživanjima kongenitalne infekcije se koristi model infekcije miševa s mišjim citomegalovirusom (MCMV). U mnogim razvojnim aspektima novookoćeni su miševi ekvivalentni ljudskom fetusu u drugom trimestru trudnoće, što je i vrijeme kada najčešće dolazi do infekcije HCMV-om u trudnoći. NK stanice su važne za kontrolu infekcije citomegalovirusom (CMV), a nedavno je pokazano da tijekom infekcije CMV-om NK stanice pokazuju i karakteristike stečene imunosti. Međutim, utjecaj kongenitalne CMV infekcije na imunološka svojstva NK stanica i dalje je uvelike nepoznat. Kako bi odredili utjecaj kongenitalne infekcije citomegalovirusom na NK stanice, inficirat ćemo novookoćene miševe MCMV-om i pratiti sazrijevanje i funkcionalnost NK stanica. Naši preliminarni rezultati ukazuju da infekcija MCMV-om snažno utječe na sazrijevanje NK stanica, te potiče iscrpljivanje NK stanica karakterizirano smanjenjem izražaja transkripcijskog faktora Eomesa. Cilj ovog projekta je karakterizirati funkcionalne, fenotipske i transkripcijske promjene NK stanica uzrokovane perinatalnom MCMV infekcijom. Nadalje, cilj je odrediti čimbenike i mehanizme koji potiču iscrpljivanje NK stanica, te odrediti mogu li se procesi iscrpljivanja NK stanica spriječiti ili ispraviti. Ujedno, ovim projektom će se odrediti uloga NK stanica u kontroli virusa, te nastanku patologije uzrokovane infekcijom novookoćenih miševa. Predloženo istraživanje će značajno pridonijeti razumijevanju patogeneze kongenitalne infekcije citomegalovirusom, ali i boljem razumijevanju biologije NK stanica, a napose u patološkim uvjetima. ]]></summary_hr><summary_en><![CDATA[Congenital human cytomegalovirus (HCMV) infection is the most common viral cause of long-term neurodevelopmental sequelae, including mental retardation, microcephaly and sensorineural hearing loss. As HCMV does not cross species barrier, we employ a mouse model in which newborn mice are infected with mouse cytomegalovirus (MCMV) to study congenital cytomegalovirus (CMV) infection. In many aspects newborn mice are developmentally equivalent to the human fetus during 2nd trimester of gestation, a time period when HCMV infection in humans is most frequently acquired during pregnancy. NK cells play an important role in control of CMV infection, and adaptive features of NK cells in response to CMV infection are recently being increasingly recognized. However, the extent to which congenital CMV infection affects and shapes NK-cell mediated immunity is largely unknown. To address this issue, we will use MCMV infected newborn mice and follow the impact of infection on the maturation and functional properties of NK cells. Our preliminary results indicate that MCMV infection strongly affects the maturation of NK cells and induces NK cell exhaustion characterized by downregulation of transcription factor Eomes. The goal of this project is to characterize functional, phenotypic and transcriptional changes in NK cells following perinatal MCMV infection. Furthermore, the goal is to characterize the factors and mechanisms that induce NK cell exhaustion and to determine if NK cell exhaustion can be prevented or reverted. In addition, in the proposed study we will determine the role of NK cells in MCMV control and virus induced pathology in newborn mice. The proposed research is an important step towards better understanding of pathogenesis of congenital CMV infection, but will as well contribute to better understanding of NK cell biology in general, and especially in pathological conditions.]]></summary_en></project><project>
<id>8125</id><title_hr><![CDATA[Od površinskih svojstava stanica alga do pokazatelja stresa u vodenim ekosustavima]]></title_hr><title_en><![CDATA[]]></title_en><user_id>513</user_id><user_firstLast_name>Nadica Ivošević DeNardis</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-9373</code><acronim><![CDATA[CELLSTRESS]]></acronim><duration>05.03.2019 - 04.03.2023</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Interdisciplinarne prirodne znanosti, </scie_field_hr><scie_field_en>Interdisciplinary natural sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>25737</team_members_id><team_members_names><![CDATA[ Doktorand: Nives Novosel ]]></team_members_names><keywords_hr><![CDATA[adhezija, AFM, alge, površinska svojstva, salinitet, stanična nanomehanika, stanični stres, temperatura, vodeni ekosustavi]]></keywords_hr><keywords_en><![CDATA[adhesion, AFM, algae, aquatic ecosystems, cell nanomechanics, cell stress, salinity, surface properties, temperature]]></keywords_en><summary_hr><![CDATA[Razumijevanje osjetljivosti različitih trofičkih razina ključno je za predviđanje utjecaja klimatskih promjena na zajednice u vodenom okolišu. CELLSTRESS projekt fokusiran je na morske mikroalge koje imaju ključnu ulogu u globalnoj primarnoj proizvodnji, glavnim biogeokemijskim ciklusima te predstavljaju temelj hranidbenoga lanca u vodenom okolišu. Odgovor stanica alga pouzdan je pokazatelj promjena u ekosustavu budući da zbog kratkoga životnog ciklusa brzo reagiraju na varijacije u okolišu. Cilj projekta je povezivanje staničnoga odgovora alga (u smislu površinskih svojstava i fiziološkoga odgovora) na glavne abiotičke stresore (temperaturu i salinitet) radi boljega razumijevanja preživljavanja i strategija prilagodbi alga u vodenim sustavima. Odabrani modelni organizmi jesu stanice alga različitih svojstava staničnih barijera, pokretljivosti i tolerancije na salinitet. Koristit ćemo komplementarne biofizičke površinske metode utemeljene na analizi pojedinačnih stanica (mikroskopija atomskih sila, kvarcna mikrovaga i elektrokemijska metoda). S obzirom na to da svaka metoda ispituje različite aspekte površinskih svojstava stanica, zajedno mogu pružiti jedinstveno razumijevanje te proširiti skalu karakterizacije stanične površine od mikro do nano razine, što je važno za razumijevanje ponašanja stanica u uvjetima stresa u morskom okolišu. Projekt CELLSTRESS mogao bi znatno doprinijeti sadašnjim spoznajama u biofizici stanica alga na temeljnoj razini. Razumijevanje površinskih svojstava stanica može pomoći u razjašnjavanju međudjelovanja mehanike i biokemije koja regulira funkcionalno ponašanje stanica. Rezultati projekta utjecat će potencijalno na buduće definiranje smjernica za zaštitu okoliša uključivanjem nanomehaničke studije staničnoga stresa u skup metoda za  ocjenu stanja ekosustava koji se proučava.]]></summary_hr><summary_en><![CDATA[A key to forecast the impact of climate change on aquatic communities is an understanding of fragility of different trophic levels in the ecosystem. The CELLSTRESS project focuses on marine microalgae as the globally important primary producers, drivers of essential biogeochemical cycles, as well as the basis of aquatic food web. Changes in algal cell responses can be an accurate marker of ecosystem perturbations, since microalgae quickly respond to subtle environmental variations due to short life cycles. The objective is to relate algal cell response (in terms of surface properties and physiological behaviour) to main abiotic environmental stressors (temperature and salinity) in order to better understand viability and adaptation strategies of algal populations in aquatic systems. Selected model organisms are algal species of varied cellular barrier properties, cell motility and salinity tolerance. We will use complementary biophysical surface methods capable of studying individual cells (atomic force microscopy, quartz crystal microbalance and electrochemical method). While each method probes a different aspect of cell surface properties, together they can provide a more unified understanding and extend the scale of cell surface characterization from micro to nano level, which is of importance to understand cell behaviour under environmental stress conditions. The CELLSTRESS project could substantially contribute to the present knowledge in the biophysics of algal cell on the fundamental level. Understanding of the cell surface properties may help to elucidate the interplay between mechanics and biochemistry that regulates functional cell behaviour. The project results may potentially impact the future environmental protection guidelines by inclusion of nanomechanical cell-stress study in the portfolio of methods to evaluate state of the ecosystem under consideration.]]></summary_en></project><project>
<id>8126</id><title_hr><![CDATA[Hiperfosforilacija, agregacija i transsinaptički prijenos tau proteina u Alzheimerovoj bolesti: analiza likvora i ispitivanje potencijalnih neuroprotektivnih spojeva]]></title_hr><title_en><![CDATA[]]></title_en><user_id>11124</user_id><user_firstLast_name>Goran Šimić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-7347</code><acronim><![CDATA[ALZTAUPROTECT]]></acronim><duration>06.05.2019 - 06.05.2023</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>26549</team_members_id><team_members_names><![CDATA[ Doktorand: Ena Španić ]]></team_members_names><keywords_hr><![CDATA[Alzheimerova bolest, cerebrospinalna tekućina (likvor), ELISA, neurofibrilarna degeneracija, neuroprotektivni spojevi, tau protein, tioflavin S ]]></keywords_hr><keywords_en><![CDATA[Alzheimer&#39;s disease, cerebrospinal fluid, ELISA, neurofibrillary degeneration, neuroprotective compounds, tau protein, thioflavine S]]></keywords_en><summary_hr><![CDATA[Za Alzheimerovu bolest (AB) ne postoji uzročno liječenje jer su brojni dosadašnji pokušaji intervencije temeljeni na amiloidnoj kaskadnoj hipotezi bili neuspješni. Usporedno s napretkom razumijevanja uloge tau proteina u patogenezi AB, metabolizam tau proteina je postao i važan terapijski cilj. Naime, smatra se da je u AB ravnoteža između kinaza i fosfataza tau proteina narušena, što dovodi do njegove hiperfosforilacije. Posljedično se povećava i frakcija tau proteina nevezanih za mikrotubule, pa se hiperfosforilirani tau monomeri vežu jedan za drugoga proizvodeći oligomere. Spajanje tau oligomera dovodi do oblikovanja sparenih uzvojitih filamenata, od kojih se sastoje sve neurofibrilarne promjene za koje je dokumentirano da predstavljaju najraniji neuropatološki događaj (tzv. &#39;&#39;pre-tangle&#39;&#39; stadij) od ključnog značaja za patogenezu AB. Ciljevi našeg projekta su: 1) bolje definirati odnos između bioloških biljega ranih stadija AB: ukupnih i fosforiliranih tau proteina, kao i amiloida ß u cerebrospinalnoj tekućini (likvoru) bolesnika s AD, MCI (blagi spoznajni poremećaj) i kontrolnih ispitanika. Uporabom inovativnog ELISA postupka i modificiranog eseja pomoću tioflavina S, u uzorcima likvora odrediti ćemo omjer između monomera i oligomera (agregata) tau proteina. Ti će novi podatci biti uspoređeni s kliničkim, neuropsihološkim i MRI nalazima; 2) testirati ćemo neke poznate i potencijalno neuroprotektivne spojeve (donepezil, klorgilin, nekoliko različitih flavonoida, te PF9601N i ASS234) na fosforilaciju tau proteina izazvanu okadaičnom kiselinom i nokodazolom u kulturama SH-SY5Y i P19 stanica. Epitope tau proteina fosforilirane na Thr181, Ser199 i Thr231 analizirati ćemo ELISA postupkom, a one na epitopima Thr202, Thr205, Ser396 i Ser404 pomoću westernske razložbe; i 3) istražiti ćemo biokemijski i imunocitokemijski transsinaptičko širenje neurofibrilarne degeneracije i razinu izraženosti tau mRNA nakon injekcije tau oligomera u entorinalnu moždanu koru miša.]]></summary_hr><summary_en><![CDATA[There is no effective treatment for Alzheimer’s disease (AD). As many drugs discovery attempts based on the amyloid cascade hypothesis have not been successful, tau protein has become an increasingly important therapeutic target owing to advances in understanding of its role in AD pathogenesis. In AD, the balance of tau kinase and phosphatase activity is shifted, creating a highly phosphorylated species of tau. This raises the fraction of unbound tau, which is no longer attached to microtubules, allowing for monomeric hyperphosphorylated tau to bind to one another to produce oligomers. Fusion of these oligomeric species leads to the formation of paired helical filaments, the primary constituent of neurofibrillary changes, which have been documented to be an early and pivotal event (so-called „pre-tangle“ stage) in the pathogenesis of AD. Our aims are: 1) to define better the relationship between the early AD biomarkers total and phospho-tau proteins, as well as amyloid ß in cerebrospinal fluid (CSF) of AD, MCI (mild cognitive impairment), and control subjects. By using innovative ELISA and modified thioflavin S binding assay on CSF samples, we will also assess the ratio between monomer and oligomer (aggregated) tau species. These new data will be correlated to clinical, neuropsychological, and MRI findings; 2) to test the effect of several known and potentially neuroprotective compounds (donepezil, clorgyline, several flavonoids, PF9601N and ASS234, among others) on tau phosphorylation induced by okadaic acid and nocodazole in SH-SY5Y and P19 cell cultures. Tau epitopes phosphorylated at Thr181, Ser199 and Thr231 residues will be analyzed by ELISA, while p-tau epitopes at Thr202, Thr205, Ser396 and Ser404 will be analyzed by Western blot; and 3) to investigate biochemically and immunocytochemically the trans-synaptic spreading of neurofibrillary degeneration and tau mRNA expression after the injection of tau oligomers in the mouse entorhinal cortex.]]></summary_en></project><project>
<id>8128</id><title_hr><![CDATA[Održiva proizvodnja biokemikalija iz sekundarnih lignoceluloznih sirovina ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4321</user_id><user_firstLast_name>Ivan-Krešimir Svetec</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-7667</code><acronim><![CDATA[OPB-SLS/SPB-LCF ]]></acronim><duration>01.11.2019 - 30.04.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Biotehnologija, </scie_field_hr><scie_field_en>Biotechnology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Food Technology and Biotechnology]]></institution_en><team_members_id>864820</team_members_id><team_members_names><![CDATA[ Doktorand: Angela Matanović ]]></team_members_names><keywords_hr><![CDATA[proizvodnja biokemikalija, lignocelulozne sirovine, integralni bioprocesi, procjena održivosti, procedura za povećanje mjerila]]></keywords_hr><keywords_en><![CDATA[biochemicals production, lignocellulose containing feedstocks, integral bioprocesses, sustainbility evaluation, scale-up procedure]]></keywords_en><summary_hr><![CDATA[Ovaj projekt bavi se razvojem održivih bioprocesa za proizvodnju biokemikalija [mikrobnih lipida (posebno poli-nezasićenih masnih kiselina), L-laktata, 2,3-butandiola i polifenola] iz sekundarnih lignoceluloznih sirovina (npr. ostataka šumarstva i prerade drva, pšenične slame, kukuruzovine i kukuruznih oklasaka, otpadne trave, kore banane i cikle, mahune graška, ljuske luka, ljuske kakaovog zrna i oraha). Predobrade tih sirovina provodit će se u visokotlačnom reaktoru uz primjenu metode koja koristi razrijeđenu kiselinu ili lužinu. U drugom stupnju predobrade, čvrsti ostatak (iz visokotlačnog reaktora) bit će podvrgnut procesu hidrolize pomoću komercijalnih enzimskih preparata ili mikroorganizama s relativno velikom celulitičkom aktivnošću. U ovom istraživanju dobiveni hidrolizati lignoceluloznih sirovina biti će analizirani, korigirat će im se sastav, te će se primijeniti za proizvodnju biokemikalija. Istraživanje proizvodnje biokemikalija bit će fokusirano na provođenje bioprocesa na polučvrstim ili čvrstim supstratima u horizontalnom rotirajućem cijevnom bioreaktoru. Odabrat će se najadekvatniji mikroorganizmi za proizvodnju proučavanih biokemikalija čije će osobine biti poboljšane primjenom metoda genetičkog inženjerstva. Za izdvajanje i pročišćavanje tih biokemikalija bit će razvijeni postupci koji će biti integrirani s procesom njihove proizvodnje da bi se poboljšali ekološki i ekonomski aspekti tih bioprocesa. Održivost proizvodnje proučavanih biokemikalija bit će procjenjena na osnovi LCA. Najefikasnija i održiva konfiguracija proučavanih bioprocesa će se definirati na osnovi LCA rezultata, te će se razviti procedura za povećanje mjerila. Procedura za povećanje mjerila će se bazirati na razvijenom integralnom matematičkom modelu bioprocesa i ostalim kriterijima za povećanje mjerila. Novi integrirani bioprocesi za proizvodnju biokemikalija iz sekundarnih lignoceluloznih sirovina glavni su rezultat ovog projekta.]]></summary_hr><summary_en><![CDATA[This project proposal is dealing with development of sustainable bioprocesses for the biochemicals [microbial lipids (especially polyunsaturated fatty acids), L-lactate, 2,3-butanediol and polyphenols] production from the waste lignocellulose containing feedstocks (e.g. forestry residues, wheat straw, corn stover and cobs, waste grass, banana and beetroot peels, pea pods, onion peels, cocoa bean husks and walnut shells). Pretreatment of these feedstocks will be performed in high pressure reactor combined with the use of dilute acid or alkaline methods. In second stage of pretreatment, the solid residues (from high pressure reactor) will be hydrolyzed be using commercial enzymes mixtures or microorganism with relatively high cellulolytic activity. In this research, obtained hydrolyzates of lignocellulose containing feedstocks will be analyzed, corrected their content and used for biochemicals production. The study of biochemicals production will be focused on the semi-solid or solid state fermentations in the horizontal rotating tubular bioreactor (HRTB). The most suitable microorganisms for these biochemicals production will be identified and improved by genetic methods. Separation and purification procedure for studied biochemicals have to be developed and integrated with their production in order to improve ecological and economical aspects of these bioprocesses. The sustainability of these biochemicals production will be evaluated through the Life Cycle Assessment (LCA). The most efficient and sustainable bioprocess configuration will be defined on the basis of LCA results and consequently scale-up procedure will be developed. The scale-up procedure will be based on the developed integral bioprocess mathematical model and other scale-up criteria. Project outcomes will be new integrated bioprocesses for biochemicals production from waste lignocellulose containing feedstocks.]]></summary_en></project><project>
<id>8129</id><title_hr><![CDATA[Dobrobit, pripadnost i društvena pravednost]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3291</user_id><user_firstLast_name>Nebojša Zelič</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-4567</code><acronim><![CDATA[Dobrobit/WellBeing]]></acronim><duration>06.05.2019 - 10.08.2023</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filozofija, </scie_field_hr><scie_field_en>Philosophy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Filozofski fakultet u Rijeci]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>26568</team_members_id><team_members_names><![CDATA[ Doktorand: Tamara Crnko ]]></team_members_names><keywords_hr><![CDATA[Dobrobit, pravednost, pripadnost, jednakost, teorija sposobnosti]]></keywords_hr><keywords_en><![CDATA[Well-being, justice, affiliation, equality, capability approach]]></keywords_en><summary_hr><![CDATA[Projekt Dobrobit, pripadnost i društvena pravednost ima četiri specifična cilja istraživanja:(1) Prvo, cilj je istražiti dosadašnju raspravu o teorijama koje prihvaćaju vrijednosni pluralizam ali ujedno smatraju da modeli socijalne pravednosti mogu i trebaju biti usmjereni ka postizanju određenih funkcija koje čine život dobrim. Sukladno tome, cilj nam je pokazati da postoji jedna koncepcija dobrog života, a to je dobrobit određena kao zadovoljenje minimuma sposobnosti kako ih određuje Nussbaum, koja osigurava ljudsko dostojanstvo.(2) Drugo, istraživanje u sljedećem koraku ima za cilj ispitati važan aspekt određenja ljudskog dostojanstva, a to je pripadnost zajednici. S obzirom na to, cilj nam je pokazati da je za dobrobit ljudskog života važno promicati pripadnost zajednici.(3) Treći cilj istraživanja je pokazati na koji način naše razumijevanje TS i promicanje pripadnosti može pružiti puno bolji okvir socijalne pravednosti u čije središte ulaze pojmovi socijalne (a ne samo distributivne) nejednakosti, detektirajući na koje bi se funkcije više trebala usmjeriti pažnja u razvijanju javnih politika koje streme ka socijalnoj jednakosti.(4) Cilj empirijskog dijela istraživanja je opisati iskustva članova neprivilegiranih ciljanih skupina hrvatskih javnih politika s obzirom na relevatnost pojedinih sposobnosti, na specifične okolnosti razvoja pojedinih sposobnosti, utjecaj ekonomskog, društvenog i političkog konteksta na  ostvarivanje pojedinih sposobnosti, te efekte različitih državnih mjera na sposobnosti i dobrobit pojedine grupe.]]></summary_hr><summary_en><![CDATA[Project Well-being, affiliation and social justice has four specific research objectives:(1) First, the aim is to explore the current discussion on the theories that accept value pluralism, but also believe that social justice models may and should be directed towards achieving certain functions that make good life. Accordingly, our aim is to show that there is a concept of good life, and that it is determined by the capabilities which ensure human dignity.(2) The second aim is to examine an important aspect of human dignity. Here we want to show that human dignity and well-being as such are established upon the specific capability for affiliation. Unlike other capability theorist we want precisely to claim that it is particularly important to promote community affiliation in order to promote well-being specific for human life.(3) In the  next step of the study, the aim is to show how our understanding of the CA and promotion of affiliation can provide insights for the state and policy makers on the development of public policies that strive for social equality, by identifying those capabilities and functionings that should be focused on in order to promote well-being.(4) The aim of empirical part of the project is to describe the experiences of the underprivileged target groups of Croatian public policies about the relevance of certain capabilities; the specific circumstances of the development of different capabilites; the influence of the economic, social and political context on the achievement of different capabilities; and the effects of different state measures on the capabilities and well-being of the specific groups.]]></summary_en></project><project>
<id>8130</id><title_hr><![CDATA[Promjene sastava patogena i imunološkog odgovora tijekom širenja areala uspješnih invazivnih vrsta slatkovodnih rakova]]></title_hr><title_en><![CDATA[]]></title_en><user_id>19913</user_id><user_firstLast_name>Sandra Hudina</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-3228</code><acronim><![CDATA[STRIVE]]></acronim><duration>01.07.2019 - 01.07.2023</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>27603</team_members_id><team_members_names><![CDATA[ Doktorand: Ana Dobrović ]]></team_members_names><keywords_hr><![CDATA[invazivne vrste, slatkovodni ekosustavi, širenje areala, imunološki odgovor, patogeni]]></keywords_hr><keywords_en><![CDATA[invasive species, freshwaters, range expansion, immune response, pathogens]]></keywords_en><summary_hr><![CDATA[Invazivne strane vrste (ISV) imaju negativan utjecaj na funkciju i usluge ekosustava diljem svijeta, te njihova predikcija i upravljanje predstavljaju globalni izazov. Brzo širenje je bitna odrednica invazivnog uspjeha dok patogeni mogu značajno mijenjati invazivni uspjeh jer utječu na ekologiju svojih domaćina. Tijekom širenja areala ulaganje u imunološki odgovor na frontama invazije vjerojatno će biti izmijenjeno zbog promijenjenog pritiska patogena i ekoloških procesa koji se javljaju tijekom širenja. Smanjena brojnost/raznolikost patogena i potencijalno manja stopa njihovog prijenosa pri niskim gustoćama domaćina mogla bi smanjiti potrebu za jakim imunološkim odgovorom. S druge strane, jedinke koje dolaze u novi okoliš potencijalno su izložene većem opsegu patogena što bi zahtijevalo pojačani imunološki odgovor. S obzirom da i smanjeni i pojačani imunološki odgovor može koristiti jedinkama na frontama invazije, nije očigledno koja od ovih tendencija će prevladati prilikom širenja areala. Predloženi projekt će ispitati ovu temu koristeći grupu uspješnih slatkovodnih ISV – deseteronožne rakove. Prvo ćemo usporediti raznolikost i zastupljenost mikrobnih zajednica i intenzitet imunološkog odgovora invazivne vrste signalnog raka (Pacifastacus leniusculus) iz središta i s fronti širenja u rijeci Korani. Zatim ćemo provesti opsežno laboratorijsko istraživanje koristeći partenogenetsku vrstu mramornog raka (Procambarus fallax f. virginalis) kako bismo identificirali učinke gustoće, imunološkog odgovora i prisutnosti patogena na rast i reprodukciju jedinki. Završno, temeljem prikupljenih podataka kvantificirati ćemo kompromise između energetskih ulaganja u imunološki odgovor naspram ulaganja u karakteristike životnog ciklusa bitnih za invazivni uspjeh koristeći dinamičko modeliranje energetskih budžeta. Ovakav sveobuhvatni okvir istraživanja omogućiti će procjenu uloge i posljedica promjena imunološkog odgovora u invazivnom uspjehu.]]></summary_hr><summary_en><![CDATA[Invasive species impair ecosystem function and services worldwide and prediction and management of successful invaders represents a global challenge. Rapid dispersal is an important determinant of invasion success. Pathogens may greatly impact invasion success since they influence host ecology/evolution. Due to altered pathogen pressures and ecological processes arising from dispersal, immune investment will likely be altered during range expansion. Lower pathogen prevalence and potentially lower transmission rates at low densities of available hosts at invasion fronts might reduce the need for strong immune response. On the other hand, in a novel environment individuals may experience a broader range of pathogens which would require increased immune investment. Since individuals at the invasion front could benefit from both elevated and decreased immune response, it is not immediately obvious which of these tendencies will prevail during range expansion. We will test these issues using a successful group of freshwater invaders – non-indigenous crayfish. Firstly, we will compare diversity and abundance of crayfish associated microbiota and the intensity of immune response in individuals of the invasive signal crayfish (Pacifastacus leniusculus) from the invasion core and invasion fronts in the Korana River, Croatia. Secondly, we will perform an extensive laboratory study using parthenogenetic marbled crayfish (Procambarus fallax f. virginalis) to identify the effects of population density, pathogen presence, and immune response on individual growth and reproduction. Based on this input, we aim to quantify potential energy allocation trade-offs between immune function and life-history traits promoting invasion success using dynamic energy budget modelling. This comprehensive framework will allow us to assess population-level consequences of immune response alterations and their role in invasion success of a species.]]></summary_en></project><project>
<id>8133</id><title_hr><![CDATA[DNA barkodiranje bioraznolikosti hrvatske faune ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>19707</user_id><user_firstLast_name>Mladen Kučinić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-1417</code><acronim><![CDATA[CroBarFauna]]></acronim><duration>14.06.2019 - 13.06.2023</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>28678</team_members_id><team_members_names><![CDATA[ Doktorand: Dora Hlebec ]]></team_members_names><keywords_hr><![CDATA[DNA barkodiranje, određivanje vrsta, bioraznolikost, kriptične vrste, zaštita]]></keywords_hr><keywords_en><![CDATA[DNA barcoding, species identification, biodiversity, cryptic species, protection]]></keywords_en><summary_hr><![CDATA[Metoda DNA barkodiranja predložena je 2003. godine kao univerzalni sistem za determinaciju biološkog materijala u smislu identifikacije vrste, a također i kao metoda za otkrivanje novih, još neopisanih vrsta koje se ne mogu međusobno razlikovati na temelju morfoloških obilježja (tzv. kriptičnih vrsta). Temelji se na određivanju slijeda nukleotida standardiziranog fragmenta mitohondrijskog gena za podjedinicu I citokrom oksidaze (COI) duljine oko 650 pb.Geografskim smještajem na zapadnom Balkanu i Mediteranu, teritorij Hrvatske predstavlja jednu od europskih „žarišnih točaka biološke raznolikosti“ (biodiversity hotspot). Visoki stupanj bioraznolikosti Hrvatske posljedica je raznolikog sastava staništa, klimatskih i hidroloških značajki kao i kompleksne geološke povijesti regije.Glavni cilj ovog istraživačkog projekta je upotrebom metode DNA barkodiranja steći uvid u opseg i geografsko rasprostranjenje ukupne genetske bioraznolikosti ciljanih skupina faune Hrvatske, te prepoznati vrste koje je neophodno dodatno detaljno istražiti s taksonomskog, filogenetskog i filogeografskog aspekta.U okviru ovog projekta prioritet će biti dan taksonomskim skupinama za koje postoje taksonomski stručnjaci među projektnim suradnicima s već djelomično prikupljenim materijalom, a s druge strane skupine koje su taksonomski potencijalno vrlo zanimljive i za koje je DNA barkodiranje već započeto u okviru ostalih Europskih inicijativa za barkodiranje.Podaci o DNA barkodovima prikupljeni ovim istraživanjem omogućiti će točniju identifikaciju velikog broja vrsta te ukazati na potrebu dodatnih istraživanja pojedinih skupina. Ukazati će vjerojatno i na nove, nepoznate kriptičke, možda i endemske vrste u Hrvatskoj, što bi imalo veliki značaj za razvitak strategija i planova za zaštitu bioraznolikosti u Hrvatskoj. Osim toga rezultati će imati moguću primjenu i u biomonitoringu kao i u epidemiološkim studijama (npr. kontrola štetnika, identifikacija i praćenje prijenosnika bolesti).]]></summary_hr><summary_en><![CDATA[DNA barcoding was proposed in 2003. as a universal system for assignment of specimens to a particular species but also as a tool for recognition of yet undescribed morphologically indistinguishable cryptic species. The method is based on the sequencing of standardized, ~650 bp long fragment of the mitochondrial cytochrome c oxidase subunit 1 gene (COI).Geographically located in the Western Balkan and Mediterranean basin, Croatian territory has great habitat diversity and represents one of the European biodiversity hotspots. High biodiversity index is consequence of very diverse habitats, climatic and hydrological features as well as complex geological history of the region. The primary goal of the proposed research project is to investigate the amount and geographic distribution of the genetic biodiversity of selected groups of Croatian fauna by using DNA barcoding methodology, flagging species for further rigorous taxonomic, phylogenetic and phylogeographic studies.In the frame of the proposed project the priority will be given to potentially taxonomically especially interesting groups, that have taxonomic expert among project collaborators, certain amount of already collected material, and groups for which DNA barcoding is already in progress within other European barcode initiatives.DNA barcodes obtained in this research will enable simple, fast and accurate identification for a great number of species, and flag certain groups for further investigation. They would most probably provide insights in some of still unrecognized or overlooked, cryptic, probably endemic species in Croatia. The assessment will be of primary importance for the development of strategies and action plans for the conservation of biodiversity in Croatia. In addition, these results will also find application in biomonitoring as well as for epidemiological studies (identification and monitoring of disease vectors).]]></summary_en></project><project>
<id>8135</id><title_hr><![CDATA[Sport, diskriminacija i integracija. Sport kao medij društvene inkluzije i participacije]]></title_hr><title_en><![CDATA[]]></title_en><user_id>19056</user_id><user_firstLast_name>Goran-Pavel Šantek</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-2607</code><acronim><![CDATA[INTEGRA]]></acronim><duration>01.05.2019 - 01.11.2023</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Etnologija i antropologija, </scie_field_hr><scie_field_en>Ethnology and anthropology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>25511</team_members_id><team_members_names><![CDATA[ Doktorand: Andrej Ivan  Nuredinović  ]]></team_members_names><keywords_hr><![CDATA[Sport, integracija, diskriminacija, inkluzija, participacija]]></keywords_hr><keywords_en><![CDATA[Sport, integration, discrimination, inclusion, participation]]></keywords_en><summary_hr><![CDATA[Pitanje društvene kohezije nerazdvojivo je povezano s problemima integracije i diskriminacije, osobito prema rasi, regionalnoj, etničkoj ili nacionalnoj pripadnosti, ali i svakoj drugoj kulturnoj različitosti.U ovom će se projektu istraživanja provoditi u dva glavna, no međusobno ispreplićuća, istraživačka smjera: a) kroz istraživanja integracije, inkluzije i diskriminacije, kako se u sportu očituju kroz navijače, članove klubova i same sportaše, te b) kroz istraživanja migranata, postmigracijskih procesa i njihova kontekstualiziranja uz sport.Istraživanje se načelno može smjestiti unutar socijalnih koncepata koji razmatraju različite modele povećanja društvene inkluzivnosti i integracije s ciljem promoviranja društveno prihvatljivih obrazaca ponašanja, a sukladno Kevin T. Leichtu (2016). Put ka društvenoj inkluziji koncipiran je stadijima Gorana Therborna (2013).Kroz istraživanje navijača i klupskih članova, ali i migranata u sportu, njihov aktivizam, proteste, peticije, kampanje, radionice, svu javnu verbalnu i vizualnu ekspresiju te druge oblike djelovanja proučit će se njihova samopercepcija i osjećaj,  kako na razini pojedinaca  tako i skupine, diskriminiranosti i marginaliziranosti te kao onih kojima su ugrožena građanska i ljudska prava te kako klubovi djeluju na inkluziju i ekskluziju građana, odnosno kao oruđa društvene kohezije.Očekivani učinak  projekta je doprinos modelima za povećanje inkluzije i umanjenje ekskluzije navijača i migranata putem sporta, odnosno sporta kao oruđa društvene kohezije.Istraživanje će biti zasnovano na različitim praksama kvalitativne i kvantitativne metodologije, posebno na diskurzivnoj analizi, sudioničkom promatranju, etnografskom bilježenju, slobodnim i strukturiranim intervjuima, analizama verbalne i vizualne ekspresije, ali i anketnom upitniku socijalne distance.]]></summary_hr><summary_en><![CDATA[Questions concerning social cohesion are inseparable from those connected with problems of integration and discrimination, especially as regards race, regional, ethnic, sexual or national difference, as well as other kinds of social, cultural and human diversity.Research will be conducted in two main, interrelated research streams: a) through researching integration, inclusion and discrimination as understood by fans, members of clubs and athletes themselves, and b) through researching refugees, migrants, post-migration processes and their contextualising within sport.Such research, according to Leichtu (2016), may be situated inside a framework using social concepts, which consider different models of increasing social inclusion and integration with the aim of promoting socially acceptable patterns of behaviour. The path to social inclusion has been conceived according to Goran Therborne (2013).Fans and/or members of sports’ clubs, but also migrants active in sport, and their self-perceptions and feelings will be studied through their activism, protests, petitions, campaigns, workshops, and through all of their forms of public verbal, visual expression and action. They will be studied both at the individual and group level, including their discrimination and marginalization, and the endangering of their civil and human rights. How clubs work to include and exclude citizens, playing a role as a tool for social cohesion, will also be considered.One of the expected effects from the project is the contribution to models of improvements of fans and migrants’ inclusion and reduction of their exclusion, that is the improvement of sport as a vehicle of social cohesion.Research will be based on various practices of qualitative and quantitative methodology, especially on discursive analysis, participant observation, ethnographic note-taking, free and structured interviews, analysis of verbal and visual expression, but also on poll questionnaire of social distance.]]></summary_en></project><project>
<id>8136</id><title_hr><![CDATA[Izolacija i enkapsulacija bioaktivnih molekula samonikle i kultivirane koprive i komorača i učinci na fiziologiju organizma]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1243</user_id><user_firstLast_name>Verica Dragović-Uzelac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-5271</code><acronim><![CDATA[PlantBioPower]]></acronim><duration>15.06.2020 - 15.02.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Prehrambena tehnologija, </scie_field_hr><scie_field_en>Food technology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Food Technology and Biotechnology]]></institution_en><team_members_id>855442</team_members_id><team_members_names><![CDATA[ Doktorand: Ena Cegledi ]]></team_members_names><keywords_hr><![CDATA[kopriva, komorač, bioaktivne molekule, biljni ekstrakti, eterična ulja, enkapsulacija, mikrobiom, mikotoksini]]></keywords_hr><keywords_en><![CDATA[nettle, fennel, bioactive molecules, plant extracts, essential oils, encapsulation, microbiome, mycotoxins]]></keywords_en><summary_hr><![CDATA[Kopriva (Urtica dioica L) i komorač (Foeniculum vulgare Mill) izvor su bioaktivnih molekula (BAM) (fitosteroli, karotenoidi, klorofili, terpenoidi, fenoli) smještenih u različitim dijelovima biljaka (nadzemni i podzemni). Rastu u prirodi kao samonikle ali se zbog postojanja brojnih kemotipova i varijabilnosti u kemijskom sastavu kultiviraju uz provođenje agrotehničkih mjera s ciljem dobivanja biljnog materijala ujednačene kvalitete.Zbog velikog broja BAM različitih molekulskih svojstava i farmakoloških učinaka (npr. antioksidacijsko, hipoglikemijsko, antivirusno, imunomodulacijsko djelovanje) mogu se koristiti u proizvodnji biljnih ekstrakata (BE) i eteričnih ulja (ETU) konvencionalnim te naprednim tehnikama ekstrakcije (npr. ASE; PHWE; MAE; SCO2 itd.). Dodatna stabilizacija BAM prisutnih u BE i ETU postiže se primjenom različitih postupaka enkapsulacije kojima se BAM inkorporiraju u zaštitni omotač nosača.Enkapsulacija omogućuje njihovu lakšu inkorporaciju u funkcionalne proizvode, naročito hidrofobnih i netopljivih molekula poput fitosterola, karotenoida, klorofila i sl. Također, BAM imaju značajan utjecaj na sastav mikrobioma crijeva te predstavljaju važan parametar u fiziološkoj modulaciji homeostaze organizma i osjetljivosti na bolesti.Stoga su ciljevi istraživanja:(i)definirati biološki potencijal samonikle koprive i komorača s različitih prirodna staništa te utvrditi utjecaj ishrane i agrotehničkih mjera na biosintezu BAM tijekom vegetacije; (ii)optimirati postupake proizvodnje BE i ETU te postupake enkapsulacije BE i ETU; (iii)odrediti djelovanje BAM koprive i komorača u prisutnosti mikotoksina na endogene probiotičke bakterije kolona, enzimsku aktivnost mikrobioma te posljedični tkivni i sistemski antioksidativni, antigenotoksični, metabolički, transkripcijski, upalni i imunosni odgovor domaćina; (iv)iznaći funkcionalne sastojake kao alternativni, ne-farmaceutski pristup u održavanju zdravlja i dobrobiti crijeva kroz promicanje crijevne mikrobne homeostaze.]]></summary_hr><summary_en><![CDATA[Nettle (Urtica dioica L.) and fennel (Foeniculum vulgare Mill) are rich source of bioactive molecules (BAM) (phytosterols, carotenoids, chlorophylls, terpenoids, phenols) located in different plant parts (over- and underground). They can be found as wild-grown, but because of a numerous chemotypes and variabilities, are being cultivated through various agrotechnical measures in order to obtain a uniform material. Due to the large number of BAMs of different properties and pharmacological effects (i.e. antioxidative, hypoglycemic, antiviral, immunomodulatory), they can be used for production of plant extracts (PE) and essential oils (EO) by conventional and novel extraction techniques (i.e. ASE; PHWE; MAE; SCO2 etc.). Their stabilization can be achieved by encapsulation where BAMs are incorporated into a protective wall material coating. Encapsulation provides easier incorporation of BAMs into functional products, especially for the hydrophobic ones (phytosterols, carotenoids, chlorophylls, etc.). Nevertheless, BAM have significant influence on the composition of intestinal microbiota and represent an important parameter in the physiological modulation of organism homeostasis and its susceptibility to diseases. Therefore, the aims of this research are to: (i) define the biological potential of wildf-grown nettle and fennel from different locations and to determine the influence of nutrition and agrotechnical measures on biosynthesis of BAM during vegetation; (ii) optimize PE and EO production and encapsulation procedures; (iii) determine the effect of nettle and fennel BAMs on endogenous probiotic colon bacteria in the presence of mycotoxins, microbial enzymatic activity and the consequent tissue and systemic antioxidative, antigenic, metabolic, transcriptional, inflammatory and immune response of the host; (iv) establish functional ingredients as an alternative, non-pharmaceutical approach to health care through promoting intestinal microbial homeostasis.]]></summary_en></project><project>
<id>8137</id><title_hr><![CDATA[The Mohamed Bin Zayed International Robotics Challenge – MBZIRC]]></title_hr><title_en><![CDATA[]]></title_en><user_id>24184</user_id><user_firstLast_name>Tamara Petrović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-4399</code><acronim><![CDATA[]]></acronim><duration>01.06.2019 - 01.12.2023</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Temeljne tehničke znanosti, </scie_field_hr><scie_field_en>Basic engineering sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>28644</team_members_id><team_members_names><![CDATA[ Doktorand: Ana  Batinović ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>8139</id><title_hr><![CDATA[Frakcionalni analogni i mješoviti sustavi obrade signala]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6508</user_id><user_firstLast_name>Dražen Jurišić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-2305</code><acronim><![CDATA[FractalAnalogFilters]]></acronim><duration>02.09.2019 - 31.08.2023</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>855338</team_members_id><team_members_names><![CDATA[ Doktorand: Andro Ćoza ]]></team_members_names><keywords_hr><![CDATA[Analogni i mješoviti krugovi, Aktivni električni filtri, Analogno sučelje, Cadence, PSpice]]></keywords_hr><keywords_en><![CDATA[Analog and mixed circuits, Active electrical filters, Analog front end,  Cadence, PSpice]]></keywords_en><summary_hr><![CDATA[U predloženom projektu će se istraživati nove metode projektiranja vremenski kontinuiranih aktivnih analognih filtara necjelobrojnog (frakcionalnog) reda za analogno sučelje u komunikacijskim sustavima. Do sada su takvi sustavi bili cjelobrojnog reda, a u ovom projektu će se izvršiti poopćavanje na necjelobrojni red. U najnovijim publikacijama dokazano je da su takve metode poželjne, ali u mnogim primjenama postoje ograničenja zbog izvedivosti frakcionalnih komponenata koji nisu još u komercijalnoj uporabi. Osim problema u proizvodnji frakcionalnih komponenata postoje i neriješeni matematički problemi kao što su analiza osjetljivosti, šuma, te stabilnosti necjelobrojnih sustava. U integriranoj realizaciji se ti problemi posebno uočavaju (visoke osjetljivosti na tolerancije komponenata, nestabilnost zbog parazita) i pozivaju na nove, nekonvencionalne i kreativne tehnike realizacije. Posebno ćemo se u istraživanju usredotočiti na analogni dio mješovitih elektroničkih sklopova, kao dio &#39;analognog sučelja&#39; prema vanjskom analognom svijetu. Pokazati ćemo da se primjenom teorije električnih krugova i linija mogu postići razna predložena poboljšanja. Istraživanja u početku će biti cjelobrojna, a zatim ćemo se koristiti frakcionalnim računom kako bi dobili što veću fleksibilnost i dodatni stupanj slobode u projektiranju. Pomoću teorije fraktala predložiti ćemo novu Besselovu filtarsku aproksimaciju. Kao rezultat projekta, uz navedena nova teoretska dostignuća, dva integrirana kruga koja služe za verifikaciju teorije, realizirat će se u tipičnoj CMOS 0,18um ili 0,35um tehnologiji za koju imamo podršku na FER-u. Ovaj projekt je važan jer unaprjeđuje analogne električne filtre, koji su kasnili u razvoju. Projekt također nudi mogućnost znanstvenog usavršavanja mladih znanstvenika u Hrvatskoj, jer su doktorski studenti i postdoktorski istraživači predviđeni kao suradnici na projektu.  Također je primjenjiv u industriji.]]></summary_hr><summary_en><![CDATA[The proposed project will explore new methods for design of continuous time analog filters of non-integer (fractional) order for analog interface in communication systems. Until now, such systems were of integer order, and in this project the generalization to the non-integer order will be done. In recent publications it has been proven that such methods are desirable, but in many applications, there are limitations due to the feasibility of fractional components that are not yet in commercial use. In addition to the problems in the production of fractional components there are unsolved mathematical problems such as sensitivity analysis, noise and stability of non-integer systems. In the integrated implementation these problems are especially observed (high sensitivity to components tolerances, instability due to parasitic components) and are calling for new, unconventional and creative techniques of realization. In particular we will focus our research on analog part of mixed electronic circuits, which is a part of the &#39;analog interface&#39; to the outside analog world. We will show that the application of the theory of electrical circuits and lines can achieve a variety of proposed improvements. Research in the beginning will be of integer order, and afterwards fractional for high flexibility and additional degree of design freedom. Using the theory of fractals we propose a new Bessel filter approximation. As a result of the project, with new theoretical achievements, two integrated circuits that are used for verification of the theory will be realized in a typical CMOS 0,18um or 0,35um technology for which we have the support of the FER. This project is important because it improves the analog electrical filters that were late in development. The project also offers the possibility of training young scientists in Croatia, because they are predicted as collaborators on this project as doctoral students and postdoctoral researchers. It is applicable for industry, too.]]></summary_en></project><project>
<id>8140</id><title_hr><![CDATA[Razvoj modela za povećanje efikasnosti izrade i funkcionalnosti grafičke ambalaže]]></title_hr><title_en><![CDATA[]]></title_en><user_id>22684</user_id><user_firstLast_name>Ante Poljičak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-7543</code><acronim><![CDATA[MEGA]]></acronim><duration>26.04.2019 - 26.07.2023</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Grafička tehnologija, </scie_field_hr><scie_field_en>Graphics technology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Grafički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Graphic Arts]]></institution_en><team_members_id>26526</team_members_id><team_members_names><![CDATA[ Doktorand: Petar Branislav Jelušić ]]></team_members_names><keywords_hr><![CDATA[grafička ambalaža, GCR, digitalni vodeni žig, funkcionalni premaz, matematičko modeliranje]]></keywords_hr><keywords_en><![CDATA[packaging, GCR, digital watermark, functional coatings, mathematical modeling]]></keywords_en><summary_hr><![CDATA[Grafička tehnologija je polje iz grane tehničkih znanosti s visokim stupnjem primjenjivosti u sustavima koji se naslanjaju na tehnološke napretke u području računarskih znanosti i inženjerstva i znanosti o materijalima. Specifičnost ovog istraživačkog područja jest upravo dvosmjerna veza između digitalnog okruženja koje se odnosi na manipulaciju i obradu slikovnih informacija i „realnog“ okruženja u kojem se navedene informacije reproduciraju koristeći različite materijale. Ovo istraživanje se provodi s ciljem razvoja modela za povećanje efikasnosti izrade i funkcionalnosti grafičke ambalaže. Navedeni cilj postići će se kroz provođenje grupa aktivnosti koje bismo mogli podijeliti u četiri osnovne skupine:-	Razvoj i evaluacija metode za zamjenu kromatskih boja akromatskom komponentom(GCR)-	Razvoj metode za implementaciju digitalnog vodenog žiga kao sredstva zaštite grafičke reprodukcije-	Karakterizacije grafičkih materijala i razvoj funkcionalnih premaza te analizom njihovih utjecaja karakteristika na višebojnu reprodukciju-	Razvoj i ocjena matematičkog modela koji će povezati utjecaj elemenata modulacije slikovne informacije i karakteristika materijala te oplemenjivanja otisaka na mehanička svojstva i vizualnu percepciju reprodukcijeOčekuje se da će rezultati ovog istraživanja doprinijeti povećanju konkurentnosti proizvodnje ambalažnog proizvoda, uz istovremeno povećanje funkcionalnosti kroz implementaciju zaštitnih elemenata u slikovni zapis te oplemenjivanje materijala poboljšavajući mu mehanička svojstva te vizualnu percepciju.Dodatni aspekt projektnog prijedloga je razvoj istraživačkog kapaciteta kroz uvođenje mladih znanstvenika u istraživački proces te njihovo usavršavanje kroz doktorski studij, pripremu publikacija te prezentacijom rezultata i diskusiji sa stručnjacima iz područja na znanstvenim skupovima.]]></summary_hr><summary_en><![CDATA[Graphic technology is a part of technical sciences which implements research advances in the various fields including computer science ad material sciences. This fact leads to a specific approach to the research as one must always have in mind the two way communication between image data manipulation in the digital and materials interaction in the printing process and product finishing.  The aim of this research proposal is to develop the model for production efficiency increase and functionality of packaging. This goal will be achieved by conducting of activities which could be divided in four main groups:- development and evaluation of the grey colour replacement (GCR) method- development of the method for implementing digital watermark as a mean to enable graphic reproduction protection- characterization of graphic materials and development of functional coatings and their impact on the multicolour graphic reproduction- development and evaluation of the mathematical model which will make connection between influence of the digital image modulation and material&#39;s characteristics and prints refining on it&#39;s mechanical properties and visual perception.It is expected that results of this research will contribute to the increase of the packaging production competitiveness, but simultaneously increase packaging functionality by implementing protecting elements in the image and material refinement to increase it&#39;s mechanical properties and visual perception.In addition, conducting of this project proposal will enable development of the research capacity by introducing young researchers into the research processes and specialization through finishing the PhD study, preparing research papers and presenting them at scientific conferences where they will be involved in discussions with researchers in the field.]]></summary_en></project><project>
<id>8142</id><title_hr><![CDATA[Automatsko raspoznavanje akcija i aktivnosti u multimedijalnom sadržaju iz domene sporta]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4775</user_id><user_firstLast_name>Marina Ivašić-Kos</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-8419</code><acronim><![CDATA[RAASS]]></acronim><duration>01.04.2019 - 31.10.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Informacijske znanosti, </scie_field_hr><scie_field_en>Information sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Fakultet informatike i digitalnih tehnologija]]></institution_hr><institution_en><![CDATA[University or Rijeka, Faculty of Informatics and Digital Technologies]]></institution_en><team_members_id>25880</team_members_id><team_members_names><![CDATA[ Doktorand: Kristina Host ]]></team_members_names><keywords_hr><![CDATA[raspoznavanje akcija, predstavljanje znanja, algoritmi zaključivanja, prostorno-vremenske značajke, vremenske neizrazite Petrijeve mreže]]></keywords_hr><keywords_en><![CDATA[action recognition, knowledge representation, inference algorithms, STIP features, timed Fuzzy Petri nets]]></keywords_en><summary_hr><![CDATA[Multimedijalni materijali poput digitalnih slika i videa postale su važan medij za pohranu i razmjenu informacija. U domeni sporta stvara se velik broj multimedijalnih materijala s različitih takmičenja, utakmica ili priprema te postoji jak interes za njihovom analizom kod sportaša i trenera, od amaterskih, preko profesionalnih do rekreativnih. U profesionalnom sportu takva analiza je danas neophodna ali još se uvijek vrši uglavnom ručnim označavanjem pojedinih akcija. Razvoj postupaka za automatsku detekciju akcija i tumačenje aktivnosti sportaša omogućio bi učinkovitiju analizu i širu dostupnost takvih rješenja svima koji se žele baviti sportom. Analiza pojedinih akcija kao što su npr. okret kod plivanja ili korak kod trčanja važna je za sportaše, trenere i fizioterapeute jer omogućuje praćenje točnosti izvođenja vježbi, unaprjeđenje njihove izvedbe te praćenje napretka. Za tumačenje više slijednih akcija i njihovo povezivanje u smislenu aktivnost potrebno je znanje iz domene sporta. Predlaže se istraživanje u kojem bi se razvili postupci za detekciju i označavanje akcija iz domene sporta u multimedijalnom sadržaju. Polazna točka za detekciju akcija bit će postupci temeljeni na strojnom učenju i značajkama koje opisuju prostorno-vremensku dimenziju multimedijalnog sadržaja. Za automatsko povezivanje i interpretaciju slijednih akcija u složenije aktivnosti razvit će se model temeljen na znanju o domeni sporta koja ima dobro definirana pravila, poznatu strukuru i kontekst te postoje jasne uloge sportaša i ostalih sudionika. Za modeliranje neizrazitog znanja o domeni i vremenskih odnosa definirat će se shema za predstavljanje znanja temeljena na teoriji vremenskih i neizrazitih Petrijevih mreža ili sličan formalizam. Zbog specifičnosti svakog sporta, u istraživanju će se razmatrati akcije iz odabranih sportova, no pri tome će se imati u vidu mogućnost primjene postupaka i na druge sportove. ]]></summary_hr><summary_en><![CDATA[Multimedia content such as digital images and video have become an important storage and exchange media. A large amount of such content from competitions, games and training sessions is constantly being created in the sports domain, and there has been a great interest for multimedia content analysis among athletes and coaches, on all levels from professional to recreational.Such analysis is indispensable in modern professional sports but is still done primarily by manual annotation of individual actions. Development of methods for automatic action detection and athlete’s activity interpretation would enable more efficient analysis and broaden the availability of analysis solutions to everyone involved with sports.Analysis of individual actions, such as swimming turns or steps in running, is important for athletes, coaches and physical therapists alike because it allows them to monitor the form of performing individual exercises, to improve the athlete’s performance and and to keep track of the progress. For interpretation of multiple sequential actions into a meaningful activity, sports domain knowledge is necessary.We propose a research in which methods for sports domain action detection and annotation in multimedia content would be developed. The starting point for action detection are methods based on machine learning and features that describe the spatio-temporal dimensions of multimedia content. For interpretation of sequential actions into more complex activities a model will be developed based on sports domain, which has well-defined rules, a known structure and context and clear roles exist for athletes and others involved. To model the fuzzy knowledge of the domain and temporal relations a knowledge representation scheme will be defined based on the theory of timed and fuzzy Petri nets or a similar formalism. Due to the specifics of different sports, actions from chosen sports will be considered in the research.]]></summary_en></project><project>
<id>8143</id><title_hr><![CDATA[Reproduktivna i regenerativna medicina – istraživanja novih platformi i potencijala (KK.01.1.1.01.0008)]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3053</user_id><user_firstLast_name>Ana Katušić Bojanac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-2852</code><acronim><![CDATA[]]></acronim><duration>06.05.2019 - 05.11.2023</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>27264</team_members_id><team_members_names><![CDATA[ Doktorand: Dajana Krsnik ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>8145</id><title_hr><![CDATA[Nanokompoziti s perovskitima za fotovoltaike, fotokatalizu i senzoriku]]></title_hr><title_en><![CDATA[]]></title_en><user_id>12522</user_id><user_firstLast_name>Krunoslav Juraić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-7558</code><acronim><![CDATA[]]></acronim><duration>01.04.2019 - 01.07.2023</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>26021</team_members_id><team_members_names><![CDATA[ Doktorand: Mario Bohač ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>8146</id><title_hr><![CDATA[Immersive Visual Technologies for Safety-critical Applications — ImmerSAFE]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5393</user_id><user_firstLast_name>Sven Lončarić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-9742</code><acronim><![CDATA[]]></acronim><duration>15.04.2019 - 14.04.2023</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>28654</team_members_id><team_members_names><![CDATA[ Doktorand: Vedran Stipetic Stipetic ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>8147</id><title_hr><![CDATA[Teorijske pretpostavke molekularne biologije]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4704</user_id><user_firstLast_name>Predrag Šustar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-7078</code><acronim><![CDATA[ThUMB]]></acronim><duration>08.04.2019 - 08.01.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filozofija, </scie_field_hr><scie_field_en>Philosophy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Filozofski fakultet u Rijeci]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>26521</team_members_id><team_members_names><![CDATA[ Doktorand: Vito Balorda ]]></team_members_names><keywords_hr><![CDATA[Gen, funkcija, prirodna selekcija, znanstveno objašnjenje, društvena spoznajna teorija, evolucija genoma, evo. očuvana područja, mehanizam, zakoni]]></keywords_hr><keywords_en><![CDATA[Gene, function, natural selection, scientific explanation, social epistemology, genome evolution, evolutionary conserved regions, mechanism, laws]]></keywords_en><summary_hr><![CDATA[Istražujemo načine utjecaja suvremene molekularne biologije na razumijevanje ključnih pojmova evolucijske biologije. Utjecaj možemo promatrati ne samo u projektima tzv. &#39;velike znanosti&#39; (big-science), prije svega, Projektu ljudskog genoma, odnosno nastavnim projektima, npr. ENCODE (ENCyclopedia Of Dna Elements), već i u mnogim projektima tzv. &#39;male znanosti&#39; (small-science). U središtu projekta bit će odnos dviju spomenutih bioloških domena – molekularne i evolucijske biologije, koji u području istraživanja (PI) filozofije biologije nije u dovoljnoj mjeri sustavno razmatran (usp., iznimno, Sarkar (2015); Doolittle (1984)).Struktura projekta je sljedeća: u prvome (1) dijelu ispitujemo kako visoko sofisticirana otkrića unutar eukariotskog genoma navode na ponovno razmatranje odgovarajućih teoretskih pojmova kao što su gen, biološka funkcija i prirodna selekcija. Ponajprije, otkrića koja se tiču mehanizma genske duplikacije, gene-sharing i mehanizama povezanih s visokim udjelom tzv. &#39;mobilne DNA&#39; te recentnih otkrića novih funkcionalnih gena u ne-kodirajućim genomskim područjima. Sva navedena otkrića zahtijevaju značajne promjene na pojmovnoj razini. Stoga želimo pokazati kako tri spomenuta ključna pojma – gen, biološka funkcija i prirodna selekcija – nisu samo povezana s dotokom novih empirijskih informacija, već su međusobno isprepletena i na teoretskoj razini. To također utječe na funkcioniranje znanstvene prakse, odnosno na znanstveno zaključivanje.U drugome (2) dijelu projekta, usredotočujemo se na različite vrste znanstvenog objašnjenja u području evolucije genoma. Naše je gledište da treba transformirati prevladavajuću mehanicističku teoriju objašnjenja, integrirajući strukturalne i etiološke vrste znanstvenog objašnjenja.Konačno, u trećem (3) dijelu, koristeći recentne znanstvene studije/analize slučaja (case-studies), istražujemo način na koji znanstvene odluke i rezultati utječu na šire javno razumijevanje funkcioniranja znanosti o živim sustavima.]]></summary_hr><summary_en><![CDATA[In this project, we examine the ways in which contemporary molecular biology is influencing the understanding of some of the key-notions in evolutionary biology. The influence in question can be traced not only in ‘big-science’ projects, most notably, the Human Genome Project (HGP) and its follow-ups, e.g., the Encyclopedia of DNA Elements (ENCODE), but also in many ‘small-science’ research projects. In that regard, we focus on the exchange between these two main biological domains as a less explored layer in philosophy of biology. Accordingly, our project is structured as follows: in Part 1, we examine how discoveries of intricate workings within eukaryotic genomes, in particular, the human genome, have clearly suggested to rethink the corresponding more theoretical notions of a gene, biological function and natural selection. Namely, the discoveries concerned with the mechanisms of gene duplication and gene sharing, then, extremely large portions of mobile DNA elements within eukaryotic genomes and, for instance, new functional genes arising from non-coding regions, all call for significant accommodations at the corresponding conceptual level. The notion of gene is closely associated with the notion of biological function, which, depending on the account endorsed, can be defined with reference to natural selection. Accordingly, we show how these three notions are theoretically intertwined in many interesting ways, which also influence scientific practice. In Part 2 of the project, we single out distinct types of explanatory practices in the area of genome evolution. We claim that, in this regard, we should overcome the standard view of mechanistic explanation and adopt an appropriate level of explanatory integration between structural and etiological explanations. Finally, in Part 3, through some recent case-studies, we explore how scientific decision-making and dissemination of scientific results relate to the public understanding of the life sciences.]]></summary_en></project><project>
<id>8148</id><title_hr><![CDATA[Analiza problema interakcije fluida i strukture i primjene]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5074</user_id><user_firstLast_name>Boris Muha</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-8366</code><acronim><![CDATA[FSIApp]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>25859</team_members_id><team_members_names><![CDATA[ Doktorand: Grgur Valentic ]]></team_members_names><keywords_hr><![CDATA[Interakcija fluida i struktura, Generalizirana rješenja, Slabo-jaka jedinstvenost, Navier-Stokesove jednadžbe, Derivacija oblika, Numeričke metode]]></keywords_hr><keywords_en><![CDATA[Fluid-structure interaction, Generalized solutions, Weak-strong uniqueness,  Navier-Stokes equations,  Shape derivative, Numerical method for PDEs]]></keywords_en><summary_hr><![CDATA[Problemi interakcije fluida i struktura (FSI problemi) opisuju dinamiku multifizikalnog sustava koji uključuje tekuće i krute/elastične komponente. Oni su svakodnevna pojava u prirodi i pojavljuju se u raznim primjenama, od biomedicine do inženjerstva. Matematički, FSI problemi su nelinearni sustavi parcijalnih diferencijalnih jednadžbi mješovitog hiperboličkog-paraboličnog tipa sa slobodnom granicom. Tok fluida opisuju 3D Navier-Stokesove jednadžbe, dok je struktura modelirana jednadžbama 3D nelinearne elastodinamike ili s nekim nižedimenzionalnim modelom (npr. Koiterova ljuska). Unatoč svojoj važnosti u primjenama i velikoj istraživačkoj aktivnosti u području FSI problema tijekom proteklih desetljeća, zbog složenosti problema čak i osnovna pitanja kao što su postojanje rješenja i dalje su otvorena u općem slučaju. Naš prvi cilj je konstrukcija slabih i rješenja koje poprimaju vrijednost u mjerama za FSI probleme koji uključuju nelinearne modele za strukturu. Drugo, proučavat ćemo jedinstvenost konstruiranih rješenja. Točnije, dokazat ćemo rezultate tipa „slabo-jake“ jedinstvenosti za razne FSI modele. Naši treći i četvrti ciljevi motivirani su primjenama u biomedicini i inženjeringu. Nastavit ćemo razvijati tehnike derivacije oblika u kontekstu FSI problema i koristiti ga za proučavanje FSI problema optimalnog upravljanja.Razni pojednostavljeni i reducirani FSI modeli često se koriste u inženjerskoj i matematičkoj literaturi, npr. FSI s linearno elastičnom ljuskom povezanom preko rubnih slip/no-slip uvjeta i jednadžba tankog sloja. Naš je cilj rigorozno izvesti i analizirati ove modele, počevši od općeg FSI modela (3D fluid povezan s 3D strukturom).Važnost FSI problema u primjenama zahtijeva dizajn i implementaciju učinkovitih numeričkih shema. Te će se sheme temeljiti na našoj teorijskoj analizi, koju planiramo upotpuniti odgovarajućom analizom konvergencije.]]></summary_hr><summary_en><![CDATA[Fluid-structure interaction (FSI) problems describe the dynamics of a multiphysics system involving fluid and solid components. They are everyday phenomena in nature and arise in various applications ranging from biomedicine to engineering. Mathematically, FSI problems are non-linear systems of partial differential equations of mixed hyperbolic-parabolic type with a moving boundary. The fluid flow is typically governed by the 3D Navier-Stokes equations, while the structure is modelled by the equations of 3D non-linear elastodynamics or with some lower dimensional model (e.g. Kotier shell). Despite its importance in applications and large research activity in the FSI area during last decades, due to the complexity of the problem, even the basic questions like the existence of solutions are still open in the general case.  Our first objective is to construct global in time weak or measure valued solutions to the FSI problems involving nonlinear models for the structure. Secondly, we will study uniqueness properties of the constructed solutions. More precisely, our goal is to prove the results of weak-strong uniqueness type for various FSI models.Our third and fourth goals are motivated by applications in biomedicine and engineering. We will further develop shape derivative techniques in the context of FSI problems and use it to study FSI optimal control problems. Various simplified and reduced FSI models are extensively used in engineering and mathematical literature, e.g. FSI with linearly elastic shells coupled via slip/no-slip boundary condition and sixth-order thin-film equations. Our goal is to rigorously derive and analyze these models, starting from the general FSI model (3D fluid coupled with 3D structure). High applicational relevance of the considered problems demands design and implementation of efficient numerical schemes. These schemes will be based on our theoretical analysis, which we plan to enhance with the corresponding convergence analysis. ]]></summary_en></project><project>
<id>8149</id><title_hr><![CDATA[ Bioprospecting Jadranskog mora – Centar izvrsnosti za bioprospecting mora]]></title_hr><title_en><![CDATA[]]></title_en><user_id>23209</user_id><user_firstLast_name>Dean Marković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-3071</code><acronim><![CDATA[]]></acronim><duration>04.03.2019 - 03.09.2023</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Fakultet biotehnologije i razvoja lijekova]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Biotechnology and Drug Development]]></institution_en><team_members_id>25643</team_members_id><team_members_names><![CDATA[ Doktorand: Dario Matulja ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>8150</id><title_hr><![CDATA[Uloga proteina Spartan u DNA replikaciji]]></title_hr><title_en><![CDATA[]]></title_en><user_id>7349</user_id><user_firstLast_name>Ivana Marinović Terzić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-7169</code><acronim><![CDATA[SprtnRep]]></acronim><duration>01.09.2019 - 02.03.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Split School of Medicine]]></institution_en><team_members_id>28748</team_members_id><team_members_names><![CDATA[ Doktorand: Mateo Glumac ]]></team_members_names><keywords_hr><![CDATA[Spartan, DVC1, DNA replikacija, DNA popravak, metaloproteazna domena, hepatocelularni karcinom ]]></keywords_hr><keywords_en><![CDATA[Spartan, DVC1, DNA replication, DNA repair, metalloprotease domain, hepatocellular carcinoma]]></keywords_en><summary_hr><![CDATA[Stabilnost kromosoma tijekom replikacije i popravka DNA je presudna za sprečavanje patološke transformacije stanica. Nedostatnosti DNA popravka uzrokuju razvojne anomalije, preuranjeno starenje (progeriju) i rak. Većina DNA oštećenja blokira napredovanje replikacijske viljuške, jer DNA polimeraza ne može prepoznati oštećene nukleotide. Na takvim mjestima, ubikvitinacija replikacijskog proteina PCNA, koji kao stezaljka kliže po DNA molekuli, pokreće mehanizam  translezijske DNA sinteze (TLS). Nedavno smo identificirali nasljednu mutaciju gena SPRTN (Spartan) kod tri bolesnika, koji su razvili progeroidni sindrom karakteriziran genomskom nestabilnosti i razvojem hepatocelularnog karcinoma (HCC) u mladosti. Druge grupe su pokazale da ja Spartan važan za aktivaciju TLS (Ghosal et al, 2012; Kim i sur, 2013). Naši rezultati pokazuju da Spartan igra važnu ulogu u normalnoj replikaciji DNA, sprečavajući replikacijski stres i održavajući stabilnosti genoma (Marinović-Terzić et al, 2014). U ovom projektu predlažemo da je Spartan metaloproteaza važna za uklanjanje kovalentno vezanih proteina i DNA, čime se omogućava napredovanje replikacijske viljuške.	Cilj ovog projekta je:1. Definirati funkciju Spartan domena,2. Odredite interakcijska svojstva / partnere proteina Spartan3. Opisati dinamiku procesa popravka DNA oštećenja u stanicama bez proteina SpartanVećina tehnika koje ćemo koristiti u ovom radu su uvriježene u našim laboratorijima: Western blot, IP, GST-pulldown, Imunofluorescentna mikroskopija, RNAi, SILAC bazirana masena spektrometrije i protočna citometrija. Koristit ćemo i jednu novu tehniku - CRISPR / Cas9 ciljano preuređivanje gena. Svi pokusi će se raditi na kulturama stanica. Ovaj projekt ima potencijal za generiranje vrlo zanimljivih rezultata i visoku vjerojatnost publiciranja u vrhunskim znanstvenim časopisima. Rezultati ovog projekta će bolje razjasniti specifičnu ulogu proteina Spartan u DNA replikaciji i održavanju genomske stabilnosti.]]></summary_hr><summary_en><![CDATA[The maintenance of chromosomal stability during DNA replication and repair is crucial for preventing patogenic transformation of a cell. Defects in DNA repair cause developmental abnormalities, premature aging, and cancer. Most types of DNA damage block the progression of replication forks, because DNA polymerases cannot recognize damaged nucleotides. At sites of stalled DNA replication fork, replication sliding clamp protein PCNA becomes ubiquitinated and thus initiates translesion DNA synthesis (TLS). Recently, we have identified germline mutations in SPRTN gene (Spartan) in three patients, who developed progeroid syndrome characterized by genomic instability and early onset hepatocellular carcinoma (HCC). Previously it was proposed that Spartan is important for activation of TLS (Ghosal et al, 2012; Kim et al, 2013). Our results show that Spartan plays an essential role in normal DNA replication by preventing DNA replication-stress and maintaining genome stability (Marinovic-Terzic et al, 2014). Here we propose that Spartan is a metaloprotease important for removal of DNA-protein crosslinks, thus enabling the progression of replication forks. Our goal in this project is to:1. Define the functions of Spartan’s domains, 2. Determine Spartans interacting properties/partners, and 3. Describe the dynamics of a DNA damage repair process in Spartan depleted cells. Most of the techniques we will use in this work are established procedures in our laboratories: Western blot, IP, GST-pull down, immunofluorescent microscopy, RNAi, SILAC based mas spectrometry and flow cytometry. One novel technique will be used as well – CRISPR/Cas9 targeted gene editing. All experiments will be performed using cultured cells. This project proposal has a potential to generate very interesting results with high possibility for publications in top scientific journals. Results of this project will help to better understand the specific role of Spartan in DNA replication and genome stability.]]></summary_en></project><project>
<id>8151</id><title_hr><![CDATA[Književne revolucije]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5581</user_id><user_firstLast_name>Zrinka Božić Blanuša</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-3086</code><acronim><![CDATA[LIRE]]></acronim><duration>04.06.2019 - 01.05.2023</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filologija, </scie_field_hr><scie_field_en>Philology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>27498</team_members_id><team_members_names><![CDATA[ Doktorand: Mirela Dakić ]]></team_members_names><keywords_hr><![CDATA[književnost, revolucije, avangarda, književni kanon, estetska autonomija, emancipacija, zajednica]]></keywords_hr><keywords_en><![CDATA[literature, revolutions, Avangarde, literary canon formation, esthetic autonomy, emantipation, community]]></keywords_en><summary_hr><![CDATA[Projektom će se istraživati naslijeđe avangarde u književnom i društvenom polju, složena međuovisnost estetske autonomije i emancipacijskih praksi. Taj će se problemski sklop analizirati s obzirom na: 1. plan na kojemu se književnost odvija (poetički, estetički, politički, ideološki), 2. logiku temporalnosti – odnos prema prošlosti i tradiciji, 3. ideologiju – građansku, nacionalne narative i projekte političkih zajednica, te na 4. dominantni tip racionalnosti, tj. prevladavajuće simboličke prakse.U prvom koraku ćemo nastaviti tradiciju istraživanja avangarde kao književnopovijesnog fenomena, ali tako da je kritički promotrimo u svjetlu novih metodologija i pristupâ te u širem srednjoeuropskom i južnoslavenskom kontekstu. Cilj projekta je razviti temeljna znanja – teorijsku i metodološku paradigmu za razumijevanje i analizu koncepta književnih revolucija, utemeljenih u estetskoj autonomiji književnosti. Ispitat ćemo kako su revolucije, Francuska i Oktobarska, generirale promjene u književnom polju i kako je književno polje odredilo razumijevanje političkih pojmova zajednice i povijesnih procesa.  Pri tome ćemo identificirati pretpostavke koje su omogućile avangardnu književnu revoluciju te opisati tekstualnu mrežu simboličkih i političkih praksi koje zajednički tvore revolucionarni, emancipatorski potencijal književnosti, posebno kanonskih autora „malih“ književnosti poput hrvatske čiji je status dodatno složen i slabo istražen zbog političkih otpora koji su se vodili na književnom polju, odvraćajući pozornost istraživača s otpora forme (Krleža, Begović, Desnica). Istražit ćemo kako se prema dominantnim tekstualnim strategijama odnosi subverzivno „žensko pismo“ (Cixious), po definiciji manjinsko, a kako feministička teorija i književna kritika, a posebno ona nastala na psihoanalitičkim temeljima. Istraživačke aktivnosti rezultirat će  teorijskom i metodološkom platformom za istraživanje avangarde te novim opisom poetike kanonskih autora hrvatskog modernizma.]]></summary_hr><summary_en><![CDATA[The research project will investigate the avant-garde literary and social legacy, with special emphasis on its intricate interrelations between aesthetic autonomy and emancipation practices, to be analyzed with respectto: i) the emergence of literature and its spheres of influence (poetic, aesthetic, political and ideological); ii) a particular logic of temporality, i.e. how newly emerged literature relates to its past and tradition; iii) ideology, i.e. national narratives, political communities, and citizenship; iv) the dominant mode of rationality, i.e. prevalent symbolic practices.Innovation in approach is in critical examination of literary avant-garde in the light of contemporary methodologies and approaches, as well as in taking a wider context into consideration (Central European and South Slavic). This will help develop fundamental knowledge, i.e. theoretical and methodological paradigm for understanding and analysis of literary revolutions with their basis in the idea of aesthetic autonomy. We will be focusing on how the French and October Revolutions induced changes in literary field and how literary field marked out the understanding of political notions. Special attention will be paid to the status of &#39;&#39;minor&#39;&#39;literature such as Croatian, even more complex and critically underexamined case due to political resistance that took place on literary field, diverting interest of literary scholars and critics from the resistance of form (Krleza, Begovic, Desnica). We will also encompass &#39;&#39;écriture féminine&#39;&#39; (Cixous), by definition minor and subversive, how it positions itself towards the patriarchal yet dominant textual strategies and concepts, along with feminist literary theory and criticism, especially its he latter&#39;s psychoanalytically informed branch. All this will offer an innovative description of poetics of canonical writers of Croatian modernity and invention of a theoretical and methodological study platform for critical research of the avant-garde.]]></summary_en></project><project>
<id>8152</id><title_hr><![CDATA[Utjecaj otvorenih požara na kvalitetu tla i voda]]></title_hr><title_en><![CDATA[]]></title_en><user_id>7706</user_id><user_firstLast_name>Ivica Kisić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-8340</code><acronim><![CDATA[POP&KTV]]></acronim><duration>18.04.2019 - 17.04.2023</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Agronomski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Agriculture]]></institution_en><team_members_id>26199</team_members_id><team_members_names><![CDATA[ Doktorand: Domina Delač ]]></team_members_names><keywords_hr><![CDATA[erozija tla vodom, degradacija tla,erozija tla vodom, degradacija tla, bioraznolikost, s bioraznolikost, staklenički plinovi, mjere ublažavanja požara]]></keywords_hr><keywords_en><![CDATA[water erosion, soil degradation, water pollution, biodiversity, greenhouse gases, mitigation of summer fire]]></keywords_en><summary_hr><![CDATA[Požari otvorenoga prostora predstavljaju prirodnu katastrofu za cijeli prostor Republike Hrvatske, a osobito za Mediteranski dio RH. Dosadašnja iskustva pokazala su da je većina požara otvorenoga prostora inicirana paljenjem vatre na napuštenom poljoprivrednom zemljištu (Obad, 1990; Defilippis, 1997; Nodilo, 2003; Mamut, 2011; Matas, 2015). U posljednjih četrdesetak godina zabilježen je izraziti porast otvorenih požara. U razdoblju od 2006. do 2015. godine u prosjeku je u RH bilo godišnje 2541 otvoreni požar, a tijekom 2017. godine do kraja listopada zabilježen je najveći broj otvorenih požara – 4248. Jedna od najvećih posljedica otvorenih požara je povećanje erozijskih procesa što uzrokuje smanjenje kvalitete tla, onečišćenje voda, povećanje emisije stakleničkih plinova te smanjenje bioraznolikosti. Utjecaj požara na okoliš bi se u okviru ovoga projekta istraživao na nekoliko lokacija u Zadarskoj i Šibensko kninskoj županiji, ovisno o veličini i lokaciji požara. Požar bi morao biti u blizini otvorena vodotoka (rijeka Krka) ili jezera (Vransko jezero). Cilj istraživanja je kvantificirati posljedice po okoliš istraživanih požara; koliko požari uzrokuju degradaciju tla i onečišćenje voda, koliko povećavaju emisiju stakleničkih plinova, te kako utječu na obnovu vegetacije.Istraživanje bi uključivalo prikaz promjena meteoroloških pojava na prostoru Zadra i Šibenika tijekom zadnjih pedeset godina, te bi se temeljem podataka iz Statističkih ljetopisa i drugih raspoloživih baza, navele postotne promjene u načinu korištenja poljoprivrednih i šumskih površina. Bit će navedene postotne promjene u odnosu urbane i ruralne populacije. Izradila bi se karta erodibilnosti tla za istraživano područje. Opisale bi se posljedice požara na okoliš – utjecaj na izgled krajolika, tlo, vode, bioraznolikost i emisiju stakleničkih plinova. Mjerilo bi se površinsko otjecanje uzrokovano različitim intenzitetom kiše.]]></summary_hr><summary_en><![CDATA[Summer fire represent a natural disaster for the entire territory of the Republic of Croatia, and especially for the Mediterranean part of the Republic of Croatia. Previous experience has shown that most of the summer fire is initiated by burning fire on abandoned agricultural land (Obad, 1990; Defilippis, 1997; Nodilo, 2003; Mamut, 2011; Matas, 2015). Over the last forty years there has been a marked increase in summer fire. In the period from 2006 to 2015, there was an average of  2541 summer fire in Croatia, and during the year 2017, by the end of October, the largest number of summer fire was recorded - 4248. One of the greatest consequences of summer fire is increasing erosion processes thus reducing soil quality, water pollution, increasing greenhouse gas emissions  and biodiversity reduction. The impact of fire on the environment would be within the framework of this project explored at several locations in Zadar and Sibenik-Knin County, depending on the size and location of fire. The fire would have to be near an open watercourse (river Krka) or a lake (lake Vransko). The aim of the study is to quantify the environmental effects of the investigated fires; how  fires cause soil degradation and water pollution, how much they increase greenhouse gas emissions and how they affect the renewal of vegetation. The research would include an overview of the meteorological phenomena occurring in the Zadar and Šibenik areas over the past fifty years, and based on the data from the Statistical Yearbook and other available bases, the percentage changes in the use of agricultural and forest areas would be stated.  A percentage change in relation to the urban and rural population will be listed. A map of soil erodibility for the studied area will be created.  The effects of  fire on the environment will be described - its impact on landscape, soil, water, biodiversity and greenhouse gas emissions. The surface runoff would be measured by different rain intensity. ]]></summary_en></project><project>
<id>8153</id><title_hr><![CDATA[Mikrolokalni defektni alati u parcijalnim diferencijalnim jednadžbama]]></title_hr><title_en><![CDATA[]]></title_en><user_id>58</user_id><user_firstLast_name>Nenad Antonić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-9109</code><acronim><![CDATA[MiTPDE]]></acronim><duration>18.12.2019 - 17.12.2023</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>864981</team_members_id><team_members_names><![CDATA[ Doktorand: Sandeep Kumar Soni ]]></team_members_names><keywords_hr><![CDATA[mikrolokalne defektne mjere, H-mjere, H-distribucije, poluklasične mjere, kompaktnost kompenzacijom, zakoni sačuvanja, Friedrichsovi sustavi]]></keywords_hr><keywords_en><![CDATA[microlocal defect measures, H-measures, H-distributions, semiclassical measures, compactness by compensation, conservation laws, Friedrichs system]]></keywords_en><summary_hr><![CDATA[Parcijalne diferencijalne jednadžbe su nesumnjivo jedan od najuspješnijih matematičkih modela za razumijevanje različitih procesa, ne samo u fizici kontinuuma, nego i u drugim znanstvenim i inženjerskim disciplinama. Premda ne postoji opća temeljna teorija parcijalnih diferencijalnih jednadžbi, usvojena je klasa metoda temeljenih na različitim pojmovima slabe konvergencije, koja je primjenjiva na rješavanje širokih klasa parcijalnih diferencijalnih jednadžbi, kao i na proučavanje drugih relevantnih pitanja, bilo intrinsičnih samoj toj teoriji, bilo vezanih uz njezinu primjenu u drugim područjima znanosti i tehnologije. Kompaktnost kompenzacijom i Youngove mjere, razvijeni skoro prije pola stoljeća, su alati razvijeni za bolje razumijevanje što se događa pri prijelazu na limes. Mikrolokalni defektni alati, poput mikrolokalnih defektnih mjera (ili H-mjera), poluklasičnih mjera, jednoskalnih H-mjera, H-distribucija i njihovih inačica, su alati koji se u novije vrijeme razvijaju za istu svrhu. Njihov daljnji razvoj i primjene u području parcijalnih diferencijalnih jednadžbi je glavni cilj istraživanja na ovom projektu. Posebno ćemo proučavati širenje gustoće mikrolokalne energije za neke jednadžbe, kao i dobru postavljenost i numeričko rješavanje heterogenih zakona sačuvanja sa stohastičkom desnom stranom, ili bez nje, za što bi odgovarajuća inačica mikrolokalnog defektnog alata trebala biti konstruirana i primijenjena. Među jednadžbama koje nas zanimaju su i one koje mijenjaju tip (na primjer, zbog visoke heterogenosti permeabilnosti kod prijenosnih procesa), a koje uzrokuju posebne poteškoće. Drugi način proučavanja takvih jednadžbi je njihov zapis u obliku Friedrichsovog sustava, što je klasa sustava prvog reda koja obuhvaća većinu linearnih jednadžbi matematičke fizike, poput klasičnih eliptičkih, paraboličkih i hiperboličkih jednadžbi, ali također i jednadžbe koje mijenjaju tip. Istovremeno, ti sustavi su vrlo pogodni za numeričku analizu.]]></summary_hr><summary_en><![CDATA[Partial differential equations are certainly one of the most successful mathematical models for understanding various processes not only in continuum physics, but in other branches of sciences and engineering. While there is no general core theory of partial differential equations, a class of methods based on various notions of weak convergence has emerged, being applicable for solving large classes of partial differential equations as well as investigating other relevant questions, either intrinsic to this theory, or pertaining to its applications in other fields of science and technology. Compactness by compensation and Young measures were the tools for better understanding of what happens on the limit developed almost half a century ago. Microlocal defect tools, like microlocal defect measures (H-measures), semiclassical measures, one-scale H-measures, H-distributions, and their variants, are the tools being developed recently for the same purpose. Their further development, and applications in the field of partial differential equations is the primal goal of the research within this project. We shall study, in particular, the propagation of microlocal energy density of certain equations, as well as the well-posedness and numerical solutions of heterogeneous conservation laws with or without a stochastic forcing, for which certain variant of microlocal defect tools should be constructed and applied. Among all equations of our interest, there are also equations that change their type (e.g. due to a high heterogeneity of the permeability in transport processes), which cause particular difficulties. Another way to study such equations is by re-writingthem in the form of Friedrichs systems, a class of first order systems which encompasses most of the linear equations of mathematical physics, like classical elliptic, parabolic and hyperbolic equations, but also the equations that change their type. At the same time they are quite convenient for numerical analysis.]]></summary_en></project><project>
<id>8155</id><title_hr><![CDATA[Razvoj i toplinska svojstava inteligentne odjeće]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3850</user_id><user_firstLast_name>Dubravko Rogale</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-7933</code><acronim><![CDATA[ThermIC]]></acronim><duration>25.04.2019 - 13.09.2023</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Tekstilna tehnologija, </scie_field_hr><scie_field_en>Textile technology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Tekstilno-tehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Textile Technology]]></institution_en><team_members_id>26338</team_members_id><team_members_names><![CDATA[ Doktorand: Daniel  Časar Veličan ]]></team_members_names><keywords_hr><![CDATA[inteligentna odjeća, toplinska svojstva, termalni maneken,  vruća ploča, toplinski konduktometar, visokotehnološke metode spajanja odjeće]]></keywords_hr><keywords_en><![CDATA[intelligent clothing, thermal properties, thermal mannequin, hot plate, heat conductor, high-tech joining methods of clothing]]></keywords_en><summary_hr><![CDATA[Tim znanstvenika na Tekstilno-tehnološkom fakultetu bavi se razvojem potpuno nove vrste odjeće nazvane inteligentna odjeća s adaptivnim termoizolacijskim svojstvima. Razvili su i patentirali dvije generacije funkcionirajućih prototipova gdje senzori prate stanje vanjskog okoliša i mikroklime inteligentne odjeće, kao i trenutačno stanje tehničkih podsustava u odjeći. Stanje interpretira ugrađeno računalo, donosi zaključke o njemu te donosi odluke o potrebnim promjenama kako bi odjevni predmet smisleno reagirao i automatski adaptirao svoja toplinska svojstva u skladu sa stanjem okoliša i fizičke aktivnosti nositelja. Početna istraživanja i razvoj ukazala su na opravdanost uvođenja koncepcije inteligentne odjeće, a prototipovi i dijelovi mjeriteljske opreme dobili su priznanje međunarodne inovacijske zajednice nizom nagrada.Ciljevi ovog projekta su usavršavanje gradbene arhitekture sustava senzor-računalo-aktuator, izrada novih ergonomski oblikovanih segmentiranih termoizolacijskih komora i tehničkih podsustava korištenjem visokotehnoloških metoda spajanja te uspostava prototipa nove generacije inteligentne odjeće.Potom će se istražiti rad i karakteristike tehničkih podsustava i uspješnosti reakcija inteligentne odjeće s adaptivnim toplinskim svojstvima.  Za to će biti potrebno uspostaviti više novih mjernih metoda i protokola za mjerenje toplinskih svojstava te uspostaviti istraživački laboratorij za cjelovita mjerenja toplinskih svojstava odjeće. Stoga će se izvesti integracija svih mjeriteljskih podsustava u novoj klima komori podesivih parametara. Na temelju tih istraživanja izvest će se završno optimiranje reakcija inteligentne odjeće i određivanje njezinih svojstava pri promjenjivim uvjetima okoliša u laboratorijskim uvjetima i pri fizičkoj aktivnosti nositelja.Konačan cilj projekta je izrada usavršenog prototipa i istraživanje karakteristika nove vrste inteligentne odjeće te uspostava laboratorija za ispitivanje toplinskih svojstava svih vrsta odjeće.]]></summary_hr><summary_en><![CDATA[A team of scientists of the Faculty of Textile Technology is dealing with the development of an intelligent clothing with adaptive thermal insulation properties. They have developed and patented two generations of prototypes where sensors monitor the state of outdoor environment and the microclimate of intelligent clothing. The integrated computer interprets the existing situation, and it makes decisions about necessary changes so that the article of clothing intelligently responds and automatically adapts its thermal properties in accordance with the environment and physical activities of the wearer. Initial research activities and development have shown the justification of introducing the concept of intelligent clothing, while prototypes and parts of metrology equipment have been recognized by the innovation community with awards. The objectives of this project are to improve the architecture of the sensor-computer-actuator system, to design new ergonomically shaped segmented thermal insulation chambers and technical subsystems using high-tech welding methods and to create a new generation of intelligent clothing prototypes. The operation and characteristics of the technical subsystems and the reaction rate of intelligent clothing will be investigated. A new research laboratory for complete measurements of thermal properties of clothing shall also be established. The integration of metrology subsystems will be performed in the new climatic chamber. On the basis of these research activities, the final optimization of the reactions of intelligent clothing will be performed, and its properties in changing environmental conditions under laboratory conditions and during physical activities of the wearer will be determined. The final objective of this project is to create a sophisticated prototype and to study the properties of new kind of intelligent clothing and to establish a new laboratory for testing thermal properties of all types of clothing.]]></summary_en></project><project>
<id>8156</id><title_hr><![CDATA[Social Engagement Framework for Addressing the Chronic – disease – challenge (SEFAC)]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5896</user_id><user_firstLast_name>Tomislav Rukavina</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-4799</code><acronim><![CDATA[]]></acronim><duration>19.06.2019 - 18.12.2023</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Javno zdravstvo i zdravstvena zaštita, </scie_field_hr><scie_field_en>Public health and health services, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Medicine]]></institution_en><team_members_id>27562</team_members_id><team_members_names><![CDATA[ Doktorand: Denis Juraga ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>8157</id><title_hr><![CDATA[3D mreže kompleksnih Ge-baziranih nanostruktura u staklima: svojstva i primjene]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1362</user_id><user_firstLast_name>Maja Buljan</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-5383</code><acronim><![CDATA[NetNano]]></acronim><duration>21.04.2019 - 20.01.2023</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>27507</team_members_id><team_members_names><![CDATA[ Doktorand: Marija Tkalčević ]]></team_members_names><keywords_hr><![CDATA[nanostrukture, samouređenje, Ge, konverzija energije, pohrana energije, zelena energija]]></keywords_hr><keywords_en><![CDATA[nanostructures, self-assembly, Ge, energy conversion, energy storage, green energy]]></keywords_en><summary_hr><![CDATA[Tijekom proteklih nekoliko godina razvili smo novu klasu materijala baziranih na pravilno uređenim Ge kvantnim točkama (KT) unutar staklene matrice. Ti materijali se pripremaju depozicijom magnetronskim rasprašenjem te naknadnim grijanjem i/ili zračenjem teškim ionima. Ovim projektom planiramo unaprijediti naše istraživanje na novu razinu istražujući kompleksne Ge-bazirane nanostrukture u staklima i njihovu primjenu u uređajima za visoko-učinkovitu konverziju energije  i njeno skladištenje.Naime, svojstva materijala baziranih na čistim, sferičnim Ge KT-ma mogu biti značajno poboljšana ili ciljano dizajnirana dodatkom drugog materijala na Ge KT-e obliku ljuske, pokrovnog sloja ili njihovom izradom u nekom kompleksnijem obliku. Ovi novi materijali, bazirani na kompleksnim Ge nanostrukturama, vrlo su zanimljivi za fundamentalnu znanost, dok njihova visoko prilagodljiva svojstva osiguravaju mogućnost primjene u modernim opto-elektroničkim uređajima.  Očekujemo uspješnu izradu nekoliko novih kompleksnih materijala, uključujući Ge/metal  jezgra/ ljuska KT-e, kontinuirane 3D mreže Ge nanožica i specifične nano-objekte nastale djelovanjem iona u različitim matricama. Razumjet ćemo kako njihova optička i električna svojstva ovise o njihovoj strukturi, te kako ih prilagoditi da bi dobili željena svojstva potrebna za primjene. Kao konačni cilj, iskoristit ćemo ih za proizvodnju energetski učinkovitih staklenika, visoko učinkovite elektrode za cijepanje vode i Li-ion baterije te za spremnike vodika.U konačnici očekujemo da će predloženi projekt donijeti važne rezultate za rješavanje aktualnih problema vezanih uz proizvodnju energije i zdrave hrane te čišćenje okoliša. Također očekujemo širenje znanstvene zajednice zainteresirane za ovu novu vrstu materijala. Ti materijali i uređaji imaju veliki potencijal da budu masovno proizvedeni i primijenjeni u suvremenoj nanotehnologiji budući da je magnetronsko rasprašenje standardna industrijska tehnika za oblaganje stakala.]]></summary_hr><summary_en><![CDATA[During the past several years we have developed a new material class based on regularly distributed Ge quantum dots (QDs) within the glass matrix. These materials are prepared by magnetron sputtering deposition followed by annealing and/or irradiation with heavy ions. We propose to advance our research to a new level by exploring complex Ge-based nanostructures in glasses and their applications in highly-efficient energy conversion and storage devices. Namely, the properties of materials based on pure, spherical Ge QDs can be significantly improved or designed specifically by addition of another material to Ge QDs in form of shell or capping layer, or by creating them to have some more complex shape. These new materials, based on complex Ge nanostructures, are very interesting from the fundamental point of view, while their highly-adjustable properties ensure their possible applications in modern opto-electronic devices.  We expect successful production of several novel complex material types including Ge/metal core/shell QDs, continuous 3D nanowire networks and ion-beam induced specific nano-objects in different matrices. We will understand how their optical and electrical properties depend on their structure and how to tailor them to get the desired properties needed for the applications. As the final goal, we will use them to produce energy-efficient greenhouses, highly-efficient electrodes for water splitting and Li-ion batteries, and hydrogen storage reservoirs.  In final, we expect that the proposed investigation will result in findings important for solving current energy-related problems, healthy food production and environment cleaning. We also expect a widening of scientific community interested for these novel material types. These materials and devices have great potential to be mass-produced and applied in modern nanotechnology since magnetron sputtering is the standard industrial technique for glass coating.]]></summary_en></project><project>
<id>8158</id><title_hr><![CDATA[Logistics for Manufacturing SMEs (L4MS)]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4210</user_id><user_firstLast_name>Marija Seder</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-4413</code><acronim><![CDATA[]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>25829</team_members_id><team_members_names><![CDATA[ Doktorand: Demijan Jurić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>8159</id><title_hr><![CDATA[IP-2016-06-7258 Fizika mnogočestičnih sustava - iskorištavanje svijeta kompleksnosti ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>25109</user_id><user_firstLast_name>Yuki Utsumi Boucher</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-9906</code><acronim><![CDATA[]]></acronim><duration>18.09.2019 - 17.03.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut za fiziku]]></institution_hr><institution_en><![CDATA[Institute of Physics in Zagreb]]></institution_en><team_members_id>28808</team_members_id><team_members_names><![CDATA[ Doktorand: Naveen Singh  Dhami ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>8160</id><title_hr><![CDATA[Volunteer and Empower: Enhancing Community Building and Social Integration through Dialogue and Collaboration amongst Young Europeans and Third Country Nationals]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6282</user_id><user_firstLast_name>Senada Šelo Šabić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-2625</code><acronim><![CDATA[]]></acronim><duration>01.08.2019 - 01.08.2023</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Politologija, </scie_field_hr><scie_field_en>Political Science, </scie_field_en><institution_hr><![CDATA[Institut za razvoj i međunarodne odnose]]></institution_hr><institution_en><![CDATA[Institute for Development and International Relations]]></institution_en><team_members_id>28367</team_members_id><team_members_names><![CDATA[ Doktorand: Nikica Kolar ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>8161</id><title_hr><![CDATA[Eksperimentalna platforma za simulaciju endovaskularnog liječenja intrakranijskih aneurizmi]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1010</user_id><user_firstLast_name>Igor Karšaj</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-9116</code><acronim><![CDATA[ElPlaSTICA]]></acronim><duration>15.04.2019 - 14.10.2023</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, </scie_field_hr><scie_field_en>Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>28647</team_members_id><team_members_names><![CDATA[ Doktorand: Toni Škugor ]]></team_members_names><keywords_hr><![CDATA[intrakranijska aneurizma, endovaskularno liječenje, potpornica za preusmjeravanje protoka, metamaterijal, 3D ispis, inverzni problem]]></keywords_hr><keywords_en><![CDATA[intracranial aneurysm, endovascular treatment, flow diverter stent, metamaterial, 3D printing, inverse problem]]></keywords_en><summary_hr><![CDATA[Potpornice za preusmjeravanje protoka postale su nedavno novi način liječenja intrakranijskih aneurizmi. Takve potpornice usmjeruju krv mimo otvora aneurizme i smanjuju utok, s ciljem izazivanja hemostaze unutar njenog lumena i, u konačnici, njene okluzije. Još uvijek nije razjašnjeno zašto takvo liječenje u nekim slučajevima dovodi do potpune okluzije, dok u drugim aneurizma ostaje otvorena ili čak raste i rupturira. Brojna istraživanja smatraju kako je promjena u hemodinamici izazvana ugrađenom potpornicom odgovorna kako za razvoj okluzije, tako i rupture. Ovaj projekt nastoji donijeti nove spoznaje o hemodinamici intrakranijske aneurizme i arterije na kojoj se nalazi. Glavni cilj projekta je proučiti karakteristike protoka u aneurizmi prije i nakon ugradnje potpornice za preusmjeravanje protoka, i preslikati te karakteristike na eksperimentalnu platformu. Središnji dio platforme bit će realistična 3D ispisana replika aneurizme, stvorena na temelju podataka bolesnika i razvijena da bude realistična i po pitanju geometrije i mehaničkog ponašanja. Nakon uspješne validacije, eksperimentalna platforma mogla bi služiti za planiranje, pripremu i uvježbavanje endovaskularnog liječenja intrakranijskih aneurizmi.]]></summary_hr><summary_en><![CDATA[In recent years, flow diverter stents have emerged as a new way of treating intracranial aneurysms. A flow diverter stent diverts blood flow past the aneurysm opening and reduces inflow with the intent of causing hemostasis inside its lumen and, eventually, occlusion of the aneurysm. It is yet unclear why in some cases the treatment leads to complete occlusion, while in other cases the aneurysm stays open or even grows and ruptures. In many studies the change in hemodynamics induced by flow diverter is considered as main factor, both for promoting occlusion and rupture. This project aims to bring new insights into hemodynamics of intracranial aneurysm and its parent artery. The main goal of the project is to study the flow conditions in an aneurysm before and after the treatment with a flow diverter, and to replicate that conditions in an experimental platform. Central part of the platform will be a realistic 3D printed replica of an aneurysm, created from patient data and developed to be realistic both in terms of geometry and mechanical behaviour. Upon successful validation, experimental platform could be used for planning, preparation and training of endovascular treatment of intracranial aneurysms.]]></summary_en></project><project>
<id>8164</id><title_hr><![CDATA[Zelene tehnologije u sintezi heterocikličkih spojeva]]></title_hr><title_en><![CDATA[]]></title_en><user_id>11301</user_id><user_firstLast_name>Maja Molnar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-3714</code><acronim><![CDATA[GREENNESS]]></acronim><duration>01.03.2019 - 18.04.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Prehrambena tehnologija, </scie_field_hr><scie_field_en>Food technology, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Prehrambeno-tehnološki fakultet]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Food Technology]]></institution_en><team_members_id>25728</team_members_id><team_members_names><![CDATA[ Doktorand: Mirjana Prkačin ]]></team_members_names><keywords_hr><![CDATA[eutektička otapala, zelena sinteza, kinazolinoni, Knoevenagelova kondenzacija, rodanin, piridin, 2,4-tiazolidindioni]]></keywords_hr><keywords_en><![CDATA[deep eutectic solvents, green synthesis, quinazolinone, Knoevenagel condensation, rhodanine, pyridine]]></keywords_en><summary_hr><![CDATA[Zelene metode sinteze u organskoj kemiji posljednjih godina postaju sve popularnije među znanstvenicima, koji ovim ekološki prihvatljivim načinom pokušavaju zamijeniti konvencionalne metode sinteze. Sinteza u eutektičkim otapalima, kao i sinteza uz pomoć mikrovalova su danas vrlo zastupljene u organskoj kemiji i mogu se okarakterizirati kao „zelene metode“ zbog malog utroška energije, kratkog reakcijskog vremena, upotrebi netoksičnih otapala, itd. Nadalje, eutektička otapala su netoksična i okolišno prihvatljiva otapala, lako se sintetiziraju iz biorazgradivih komponenti i pokazuju brojne prednosti u odnosu na konvencionalna organska otapala. Upravo zbog navedenih prednosti u odnosu na konvencionalne metode sinteze, osobito vezano za utjecaj na okoliš i ekološki aspekt, ove metode će se koristiti za sintezu nekih keterocikličkih spojeva na bazi kumarna, kinazolinona i piridina s potencijalnom biološkom aktivnošću.Glavni cilj ovog projekta je razviti ekološki prihvatljive metode sinteze važnih bioaktivnih heterocikličkih spojeva. Projekt će se uključivati 1) Sintezu derivata kinazolinona, 2) Knoevenagelovu kondenzaciju i 3) Sintezu derivata piridina, reakcije koje se svakodnevno provode u brojnim istraživačkim laboratorijima. Svakodnevno provođenje ovih reakcija konvencionalnim putem uzrok je povećanoj upotrebi, generiranju i odlaganju štetnih tvari, što ima golem negativan učinak na okoliš. Zelene metode u ovom slučaju su više nego dobrodošle. Stoga će se sve gore opisane reakcije optimirati i provesti u eutektičkim otapalima, uz miješanje i grijanje ili u kombinaciji s mikrovalovima i ultrazvukom. Na projektu će raditi dva doktoranda, u okviru svojih tema doktorskog rada, svaki na specifičnoj vrsti spojeva.]]></summary_hr><summary_en><![CDATA[Green methods in organic synthesis have been of interest for many chemists nowadays since there is a tendency of developing environmentally friendly and acceptable synthetic routes. Synthesis in deep eutectic solvents and microwave synthesis is often characterized as “green” due to their low energy consumption, short reaction times, use of non-toxic solvents, etc. Moreover, deep eutectic solvents are nontoxic and environmentally acceptable, easily synthesized from biodegradable components and show numerous advantages compared to conventional organic solvents. Therefore, due to their advantages compared to conventional synthesis, emphasising the environment safety and ecological issues, those methods will be employed in synthesis of some coumarin, quinazolinone and pyridine heterocyclic compounds with potential biological activity. The main goal of this project is to develop procedures for synthesis of various biologically active and important heterocycles using green technologies. This project will be performed considering three (3) aspects; 1) Synthesis of quinazolinone derivatives, 2) Knoevenagel condensation and 3) Synthesis of pyridine derivatives. All of these reactions are mostly performed conventionally and are very common in chemical laboratories, utilized in every day work of many researchers. Due to their daily performance, many toxic organic chemicals and solvents are spent, generated and disposed, causing an inormous impact on environment. Green technologies in this regard are more than welcomed. Therefore, all reactions described above will be optimized and performed in deep eutectic solvents, with stirring and heating, microwaves and ultrasound. Two doctoral students will be working on this project, each one of them dealing with specific type of compounds or reactions and it is expected that they gain their PhD diploma within this project. ]]></summary_en></project><project>
<id>8166</id><title_hr><![CDATA[Znanstveni centar izvrsnosti za temeljnu, kliničku i translacijsku neuroznanost]]></title_hr><title_en><![CDATA[]]></title_en><user_id>12709</user_id><user_firstLast_name>Siniša Škokić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-09</proposal_call><code>DOK-2018-09-8607</code><acronim><![CDATA[]]></acronim><duration>01.07.2019 - 01.07.2023</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>27643</team_members_id><team_members_names><![CDATA[ Doktorand: Tomislav Smolčić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>8192</id><title_hr><![CDATA[Uloga RNA vezujućeg proteina CELF 1 u neuronalnom razvoju čovjeka]]></title_hr><title_en><![CDATA[Role of RNA binding protein CELF1 in normal and abnormal human neuronal development ]]></title_en><user_id>5534</user_id><user_firstLast_name>Zeljka Krsnik</user_firstLast_name><svouser_id>25496</svouser_id><svouser_firstLast_name>Mladen-Roko Rasin</svouser_firstLast_name><proposal_type>PZS</proposal_type><proposal_call>2019-02</proposal_call><code>PZS-2019-02-4710</code><acronim><![CDATA[CELF1NeuDev]]></acronim><duration>01.01.2020 - 31.05.2023</duration><status>Završio</status><financ_value>254.588,89 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>22824, 6442, 25513, 25528, 25497, 25474, 25578, 855745, 22457, 861731, 19170, </team_members_id><team_members_names><![CDATA[Iva Salamon, Martina Rinčić, David Menassa, Alvaro Duque, Luka  Turkalj, Terezija Miškić, James Millonig, Janja Kopić, Iris Žunić Išasegi , Alisa Junaković, Jure Krasić, ]]></team_members_names><keywords_hr><![CDATA[cerebral cortex, mRNA translation, polysome, transcriptome, human iPSCs, neural progenitor cells (NPCs), induced neurons (iNs)]]></keywords_hr><keywords_en><![CDATA[moždana kora, mRNA translacija, polisomi, transkriptom, ljudske iPSC, neuralne progenitorske stanice, inducirani neuroni]]></keywords_en><summary_hr><![CDATA[Vremenski i prostorno precizno koordiniran izražaj gena preduvjet je normalnog razvoja mozga. Za razliku od regulacije transkripcije koja se desetljećima proučavala, tek je nedavno pokazana važnost regulacije sinteze proteina tijekom razvoja mozga miša. Grupa prof. Rašina sa Sveučilišta Rutgers je nedavno pokazala na mišjem modelu kako se mRNA molekule najprije prepisuju, a nakon toga čekaju signal za translaciju u proteine, pri čemu ključnu ulogu imaju RNA-vezujući proteini (engl. RNA-binding proteins, RBP). Jedan od tih proteina, Celf1, potreban je za razvoj progenitorskih stanica i glutamatergičkih neurona tijekom razvoja moždane kore miša. Unatoč impresivnom napretku u saznanju važne uloge mRNA translacije u regulaciji razvoja moždane kore miša posljednjih godina, niz pitanja ostaje otvoreno, uključujući temeljnog pitanja razvojne neurobiologije: da li je isti regulatorni mehanizam potreban i za neuronalni razvoj u čovjeka? Na osnovi preliminarnih rezultata, naša je hipoteza da ljudski CELF1 regulira mRNA translaciju tijekom razvoja neuralnih progenitorskih stanica, te da je CELF1-regulacija ključna tijekom razvoja moždane kore čovjeka. Hipotezu ćemo testirati u sklopu sljedećih ciljeva: (1) Utvrditi funkcije CELF1 u razvoju humanih neuralnih progenitorskih stanica (NPC) i induciranih neurona (iN) dobivenih iz normalnih induciranih pluripotentnih stanica (iPSC); (2) Utvrditi mRNA-kandidate koji imaju ulogu u regulaciji CELF1 u humanim NPC i iN; (3) Utvrditi funkciju gena-kandidata u humanim NPC i iN. Na kraju predloženog istraživanja, utvrdit ćemo mRNA koje su translacijski regulirane u različitim stadijima neuronalnog razvoja čovjeka, njihovu funkciju, te gdje i kada su eksprimirane, te ćemo značajno unaprijediti naše razumijevanje uloge mRNA translacije u neuronalnom razvoju moždane kore čovjeka.]]></summary_hr><summary_en><![CDATA[Neurodevelopment relies on the precise orchestration of gene expression at specific developmental times in particular cell types. We have known for decades the importance of transcriptional regulation in cortical development. However, only recently mRNA translation has emerged as another important regulatory pathway that controls mouse cortical development. Dr. Rasin group has shown that mRNAs are transcribed but then await a signal to be translated into protein and mRNA translation in the developing mouse cortex is regulated by RNA binding proteins (RBPs). One of these RBPs, Celf1, is expressed in early progenitors and is needed for differentiation of glutamatergic neurons. Despite these impressive advances, research gaps remain including whether mRNA translation regulates human neurodevelopment – a fundamental question in neuroscience. To address this question, our team will combine the following resources: human cortical development (Krsnik), mRNA translation regulation (Rasin) and human neural precursor cells (Millonig). We will test the following hypothesis: human CELF1 regulates mRNA translation during human NPC and neuronal development and the downstream CELF1 regulated mRNAs will be important regulators of human neurodevelopment. To test this hypothesis the assembled international research team will perform the following three aims: (1) CELF1 will be knocked-down in human NPCs and induced neurons and the effect on development determined; (2) To identify the mRNAs regulated by CELF1, an unbiased RNA-seq screen will be performed and expression pattern determined; (3): The function of CELF1-regulated mRNAs will be tested in human NPC and induced neurons. At the completion of this study, we will determine the mRNAs that are translationally regulated during human neuronal development, their functions,  when and where they are expressed, significantly extending our understand of mRNA translation and its role in human neurodevelopment]]></summary_en></project><project>
<id>8193</id><title_hr><![CDATA[Višefazni pristup za dešifriranje mikrobne ekologije i biotehnološkog potencijala geotermalnih izvora u Hrvatskoj]]></title_hr><title_en><![CDATA[A multiphasic approach for deciphering the microbial ecology and biotechnological potential of hot springs in Croatia]]></title_en><user_id>74</user_id><user_firstLast_name>Sandi  Orlić </user_firstLast_name><svouser_id>12469</svouser_id><svouser_firstLast_name>Petra Pjevac</svouser_firstLast_name><proposal_type>PZS</proposal_type><proposal_call>2019-02</proposal_call><code>PZS-2019-02-7373</code><acronim><![CDATA[MAMEBio]]></acronim><duration>01.10.2019 - 31.05.2023</duration><status>Završio</status><financ_value>279.315,15 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Biotehnologija, Interdisciplinarne biotehničke znanosti, </scie_field_hr><scie_field_en>Biotechnology, Interdisciplinary biotechnical sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>2511, 5844, 363, 864839, 864840, </team_members_id><team_members_names><![CDATA[Marija Vuković Domanovac, Tamara Marković, Martina Sudar, Maja Mitrović, Ema Kostesic, ]]></team_members_names><keywords_hr><![CDATA[geotermalni izvori, sekvenciranje slijedeće generacije,  biotehnološko istraživanje, ekstermofili , vodena mikrobna ekologija, bakterijska raznolikost]]></keywords_hr><keywords_en><![CDATA[Geothermal springs, next generation sequencing, biotechnological bioprospecting, extremophiles, aquatic microbial ecology, bacterial diversity ]]></keywords_en><summary_hr><![CDATA[Istraživanje bakterija i arheja koje žive u  geotermalnim sustavima bilo je presudno za naše razumijevanje raznolikosti i povijesti života na Zemlji. U posljednjih nekoliko godina, pojavom sekvenciranja genoma pojavile su se velike mogućnosti u istraživanju genomskom potencijala i metaboličke aktivnost globalnog mikrobioma. Genomi od više od  300 000 bakterija I više od  3000 arhea pružili su ključni uvid u, na primjer, njihovu evoluciju i ulogu u biogeokemijskim ciklusima, njihovim načinima patogeneze i antimikrobne rezistencije i genetskim osnovicama na kojima se temelji njihov biotehnološki potencijal. Stoga podati iz metagenoma dobiveni izravno iz DNK okoliša mogu pružiti nove, neviđene uvide u strukturu, funkciju i metabolički kapacitet mikrobne zajednice. Istraživanje enzima koji djeluju u ekstremnim uvjetima od posebnog je interesa za mnoge biotehnološke i industrijske procese. U Hrvatskoj je jedan takav okoliš, geotermalni izvori, gotovo potpuno neistražen i predstavlja potencijalni izvor mikrobnih vrsta, novih putova i enzima. Glavni cilj prijedloga je upotreba visoko paralelnog kvantitativnog sekvenciranja gena rRNA SSU, sekvenciranje amplikona SSD cDNA i kvantitativna PCR reverzne transkripcije, kao i metagenomika i metatranskriptomika za analizu sastava, dinamike i funkcije mikrobne zajednice, kao i biotehnološke perspektive u brojnim hrvatskim geotermalnim izvorima. Suradnja i umrežavanje s vrhunskim europskim znanstvenicima pridonijet će daljnjem razvoju kvalitete i konkurentnosti istraživanja mikrobne ekologije u Hrvatskoj. Rezultati projekta bit će vidljivi kroz snažniju buduću suradnju s biotehnološkim tvrtkama, što će imati snažan utjecaj na razvoj modernih industrija u Hrvatskoj.]]></summary_hr><summary_en><![CDATA[The investigation of the Bacteria and Archaea inhabiting geothermal systems has been critical to our understanding of the diversity and history of life on Earth. In recent years, the advent of genome sequencing has opened a window into the genomic potential and metabolic activity of the global microbiome. The genomes of >300 000 Bacteria and >3000 Archaea  have provided key insights into, for example, their evolution and role in biogeochemical cycles, their modes of pathogenesis and antimicrobial resistance and the genetic determinants underlying their biotechnological potential. Therefore, metagenomic datasets derived directly from environmental DNA can provide novel, unprecedented insights into microbial community structure, function and metabolic capacity. The bioprospecting of enzymes that operate under extreme conditions is of particular interest for many biotechnological and industrial processes. In Croatia, one such environment, geothermal springs, are almost entirely unexplored and represent a potential source of microbial species, novel pathways, and enzymes. The main objective of the proposal is using highly parallel quantitative SSU rRNA gene sequencing, SSU cDNA amplicon sequencing and reverse-transcription quantitative PCR, as well as metagenomic and metatranscriptomics to analyze the microbial community composition, dynamics, and function, as well as biotechnological perspectives in Croatia’s numerous geothermal springs. The collaboration and networking with top level European scientist will contribute to the further development quality and competitiveness of microbial ecology research in Croatia. The results of the project will be visible through a stronger future cooperation with biotechnology companies which will have a strong impact on the development of bio-based industries in Croatia.]]></summary_en></project><project>
<id>8194</id><title_hr><![CDATA[Fleksibilnost mikromreža s visokim udjelom pretvarača]]></title_hr><title_en><![CDATA[Flexibility of Converter-based Microgrids]]></title_en><user_id>7162</user_id><user_firstLast_name>Hrvoje Pandžić</user_firstLast_name><svouser_id>25696</svouser_id><svouser_firstLast_name>Damir Novosel</svouser_firstLast_name><proposal_type>PZS</proposal_type><proposal_call>2019-02</proposal_call><code>PZS-2019-02-7747</code><acronim><![CDATA[FLEXIBASE]]></acronim><duration>01.10.2019 - 31.05.2023</duration><status>Završio</status><financ_value>291.499,10 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>25507, 25372, 7001, 6990, 6996, 25525, 25526, 20291, 7348, 865405, 865034, 856080, 855435, 855441, </team_members_id><team_members_names><![CDATA[Yury Dvorkin, Marija Miletić, Tomislav Capuder, Zeljko Tomsic, Marko Delimar, Mateo Beus, Danijel Topić, Hrvoje Bašić, Juraj Havelka, Petra Miljan, Bojana Barać, Nikolina Čović, Ivan Grcić, Domagoj Badanjak, ]]></team_members_names><keywords_hr><![CDATA[mikromreže, AC/DC pretvarači, relejna zaštita, tržište električne energije, fleksibilnost, laboratorijsko ispitivanje]]></keywords_hr><keywords_en><![CDATA[microgrids, AC/DC converters, relay protection, electricity markets, flexibility, laboratory testing]]></keywords_en><summary_hr><![CDATA[Integracijom brzih punionica električnih vozila, baterijskih spremnika energije, fotonaponskih panela i istosmjernih tereta, povećava se količina mikromreža s visokim udjelom AC/DC pretvarača. Projekt je usmjeren na algoritme upravljanja i zaštite u takvim mikromrežama te na njihovu interakciju s distribucijskim sustavom i tržišnim sudionicima u svrhu monetizacije fleksibilnosti i upravljivosti koje mikromreže s visokim udjelom pretvarača posjeduju. Prvi cilj projekta je razvoj algoritama za estimaciju i maksimizaciju dostupne fleksibilnosti u mikromreži s visokim udjelom pretvarača korištenjem hijerarhijskog upravljanja koje će se temeljiti na dva upravljačka sloja. Gornji upravljački sloj minimizira dugoročne troškove pogona mikromreže, dok donji upravljački sloj osigurava kratkoročno zadovoljavanje tehničkih ograničenja tj. stabilnosti pogona mikromreže u mrežnom i otočnom radu. Na primjenu ovako definiranog upravljačkog koncepta mikromreže nadovezuje se drugi cilj projekta, a to je algoritam za bolju koordinaciju rada zaštitnih uređaja koji će omogućiti pogon mikromreže bliže granicama stabilnosti na temelju mjerenja i prikupljenih podataka. Pogon mikromreže bliže granicama stabilnosti povećava dostupnu fleksibilnost koja će se kroz treći cilj projekta nuditi na tržištima energije i pomoćnih usluga tržišnim sudionicima i operatorima sustava. Naime, tržišni algoritam imat će mogućnost kvantifikacije razine dostupne fleksibilnosti u ovisnosti o trenutnom položaju radne točke i prognozama za budućnost uz optimiziranu koordinaciju rada zaštitnih uređaja mikromreže. Nadalje, s obzirom da je jedna od osnovnih značajki i prednosti mikromreže otpornost na vanjske kvarove, četvrti je cilj projekta razviti model optimalnog pogona mikromreže koja u svakom trenutku može prijeći u otočni pogon uz zadržavanje stabilnosti i napajanja svojih potrošača. Svi razvijeni algoritmi testirat će se i verificirati u stvarnoj laboratorijskoj mikromreži s velikim udjelom pretvarača.]]></summary_hr><summary_en><![CDATA[Integration of fast DC chargers for electric vehicles, battery energy storage, photovoltaics and DC loads results in microgrids with a large share of AC/DC power converters. The project focuses on control and protection algorithms in such microgrids, as well as on their interaction with the distribution system and market participants with the goal of monetizing the flexibility and controllability of the converter-based microgrids. The first goal of this project is to develop algorithms for estimation and maximization of the available flexibility within a converter-based microgrid using the hierarchical control concept based on two layers. The upper control layer minimizes the long-run operational costs, while the lower control layer ensures feasibility of the technical constraints, i.e. microgrid stability both in on-grid and island operation. Application of this control concept is further enhanced with the second project goal, which is the algorithm for improved coordination of relay protection devices that enables microgrid operation closer to its stability limits based on measurements and historical data. Microgrid operation closer to its stability limits increases the available flexibility, which will be offered, in the third goal of this project, in energy and ancillary service markets to the market participants and system operators. The optimal market offering algorithm will be able to quantify the available flexibility within the microgrid considering its current operating point, future forecasts and coordinated operation of protection relays. Finally, since one of the main characteristics and advantages of microgrids in general is resilience to external faults, the fourth project goal is to develop a model of optimal operation model of a converter-based microgrid which can switch to the island operation at any time. All the developed algorithms will be tested and verified in an actual laboratory microgrid based on AC/DC converters.]]></summary_en></project><project>
<id>8200</id><title_hr><![CDATA[Ispitivanje stavova djece u Hrvatskoj o matematici – Razvoj marketinških strategija za veću uspješnost kurikularne reforme ]]></title_hr><title_en><![CDATA[Croatian School Children’s Attitudes About Mathematics: Evaluation and Outreach Strategies for a More Effective Curriculum Reform]]></title_en><user_id>25499</user_id><user_firstLast_name>Ružica Brečić</user_firstLast_name><svouser_id>25670</svouser_id><svouser_firstLast_name>Dario Cvencek</svouser_firstLast_name><proposal_type>PZS</proposal_type><proposal_call>2019-02</proposal_call><code>PZS-2019-02-9814</code><acronim><![CDATA[MATH ATTDS]]></acronim><duration>01.10.2019 - 01.05.2023</duration><status>Završio</status><financ_value>275.056,03 eur</financ_value><scie_area_hr>Društvene znanosti, Interdiciplinarne znanosti, </scie_area_hr><scie_area_en>Social sciences, Interdisciplinary scientific area, </scie_area_en><scie_field_hr>Interdisciplinarne društvene znanosti, Ekonomija, Psihologija, </scie_field_hr><scie_field_en>Interdisciplinary social sciences, Economy, Psychology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Ekonomski fakultet u Zagrebu]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Economics and Business]]></institution_en><team_members_id>25540, 855349, 855350, </team_members_id><team_members_names><![CDATA[Miroslav Mandić, Dora Gaćeša, David Skala, ]]></team_members_names><keywords_hr><![CDATA[Stavovi djece, Matematika, Samopouzdanje, Procjena, Komunikacija]]></keywords_hr><keywords_en><![CDATA[Children’s Attitudes, Math, Self-Esteem, Evaluation, Outreach strategies ]]></keywords_en><summary_hr><![CDATA[Trenutačno, edukatorima u Hrvatskoj nedostaju načini mjerenja uspješnosti Vladinih ulaganja u poboljšanje nastave matematike, a pogotovo su slabo korištene socio-emocionalne mjere za procjenu učinkovitosti. Predloženi projekt istražit će dva ključna pitanja: Je li hrvatska kurikularna reforma učinkovita u poticanju pozitivnijih stavova o matematici/samopoimanja i matematike kod učenika osnovnih škola? Koje marketinške strategije su uspješne za promicanje / komunikaciju HKR-a širom zemlje?Projekt koji predlažemo uključuje dijagnostički pristup za praćenje/vrednovanje socio-emocionalnog učenja učenika korištenjem implicitnog testa asocijacija (IAT) zajedno s eksplicitnim mjerama (samo-izvješća). Ove mjere pružaju novi način praćenja pozitivnih promjena u uvjerenjima i stavovima učenika o matematici tijekom vremena. Originalni doprinos našeg prijedloga je kombinacija implicitnih i eksplicitnih mjera za praćenje promjena. Dodatni doprinos je razvoj novih komunikacijskih strategija koje su prilagođene praktičarima, kako bi se rezultati podijelili s nastavnicima i roditeljima te se objasnilo njihovo značenje za svakodnevnu praksu s djecom.Razvili smo načine jednostavnog upravljanja implicitnim i eksplicitnim mjerama za procjenu stavova o matematici i samopoimanju, te smo te nove metode prilagodili uporabi u Hrvatskoj. Metode su utemeljene na dokazima, psihometrijski su čvrste i osjetljive na individualne razlike. Ravzijene mjere mogu se koristiti u izvornim školskim okruženjima kao dijagnostički alati kojima upravljaju učitelji kako bi pratili učenje djece tijekom vremena.Predložena kombinacija implicitnih i eksplicitnih mjera pruža korisnu, standardiziranu metriku za kvantificiranje uspjeha u cijelom školskom okruženju tijekom akademske godine. Predloženi projekt također će omogućiti koristan model za učinkovito partnerstvo za istraživanje u praksi, što će potencijalno omogućiti proširenje predloženog rada na druga školske okružja u regiji i šire.]]></summary_hr><summary_en><![CDATA[Currently, Croatian educators lack data using social emotional measurements to assess the effectiveness of governmental investments to improve mathematics instruction in Croatia.The proposed project will investigate two key questions: Is Croatian Curricular Reform (CCR) effective in fostering more positive math self-concepts/math attitudes in elementary school students? Which outreach marketing strategies are most effective for nation-wide promotion/ communication of CCR?Our proposed approach involves a diagnostic approach to track/evaluate students’ socio-emotional learning by using implicit (IAT) in conjunction with explicit (self-report) measures. These measures provide a novel way of tracking positive changes in students’ beliefs and attitudes about mathematics over time. Thus, a unique strength of our proposal is that we combine both implicit and explicit measures of change. An added strength is the development of new, practitioner-friendly communication strategies to share our results with educators and explain their meaning for teachers’ daily practice.We have developed ways of easily administering both implicit and explicit measures of math attitudes and self-concepts, and have adapted these novel methods for use in Croatia. Our methods are evidence-based, psychometrically sound, and sensitive to individual differences. These measures can be used in authentic school settings as diagnostic, teacher-administered tools to track their students’ learning over time.Our proposed combination of implicit and explicit measures provides a useful, standardized metric to quantify success across the school district over the course of an academic year. The proposed project will also provide a useful model for an effective research-to-practice partnership in the school district, which will potentially allow for the proposed work to be extended to other school districts in the region and beyond.]]></summary_en></project><project>
<id>8208</id><title_hr><![CDATA[Fraktalna svojstva bifurkacija dinamičkih sustava]]></title_hr><title_en><![CDATA[Fractal properties of bifurcations of dynamical systems]]></title_en><user_id>1391</user_id><user_firstLast_name>Vesna Županović</user_firstLast_name><svouser_id>3200</svouser_id><svouser_firstLast_name>Pavao Mardešić</svouser_firstLast_name><proposal_type>PZS</proposal_type><proposal_call>2019-02</proposal_call><code>PZS-2019-02-3055</code><acronim><![CDATA[FRABDYN]]></acronim><duration>01.10.2019 - 31.05.2023</duration><status>Završio</status><financ_value>217.434,42 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>2841, 2709, 3773, 2932, 29727, 856174, </team_members_id><team_members_names><![CDATA[Renato Huzak, Maja Resman, Domagoj Vlah, Goran Radunović, Vlatko Crnković, Martin Klimes, ]]></team_members_names><keywords_hr><![CDATA[dinamički sustav, bifurkacija, fraktalna geometrija, kompleksna analiza, singularne perturbacije]]></keywords_hr><keywords_en><![CDATA[dynamical system, bifurcation, fractal geometry, complex analysis, singular perturbation]]></keywords_en><summary_hr><![CDATA[Cilj projekta je novi pristup teoriji bifurkacija. Proučavamo dinamičke sustave, posebice singularne perturbacije, fraktalnu geometriju, kompleksnu analizu i numeričko modeliranje dinamičkih sustava. Kvalitativna teorija proučava rješenja jednadžbi bez eksplicitnog rješavanja jednadžbi. Te jednadžbe prirodno ovise o parametrima, stoga proučavamo teoriju bifurkacija, gdje bifurkacija znači kvalitativnu promjenu u ponašanju sustava. Sustav koji prolazi kroz bifurkaciju može promijeniti stabilnost, što je ključni problem u matematičkom modeliranju. Poznati neriješeni 16. Hilbertov problem traži uniformnu  gornju ogradu za broj graničnih ciklusa polinomijalnog vektorskog polja. Granični ciklusi mogu  nastati bifurkacijama i iz singularnih perturbacija sustava. U ovom projektu naš inovativni pristup je određivanje svojstava bifurkacija dinamičkih sustava iz mjere A(fr,E), te iz fraktalnih zeta funkcija Z(fr,E),  E-okolina orbita sustava fr, ovisnog o parametru r. Fraktalna dimenzija koja se naziva box dimenzija određena je iz vodećeg člana asimptotskog razvoja E –>A(fr,E), ali i drugi članovi razvoja također daju važne informacije o sustavu. Kompleksna analiza i Mellinova transformacija glavni su alati u konstrukciji zeta funkcija Z(fr,E) Nadalje, razvit će se nove numeričke metode za otkrivanje bifurkacija na temelju fraktalnog pristupa. Ove metode će uključivati numeričke izračune temeljene na GPU-u, nelinearnoj optimizaciji i finom uzorkovanju prostora bifurkacijskih parametara. Granični ciklusi rođeni u singularnim perturbacijama, često nazvani patkastim ciklusima (canardima), proučit će se primjenom box dimenzije  i fraktalnih zeta funkcija kako bi se dobila cikličnost sustava. Fenomen canarda je fenomen u kojem granični ciklus stvoren u Hopfovoj bifurkaciji za mali parameter, neko vrijeme ostaje „mali“, ali se onda vrlo brzo mijenja u  „veliki“ ciklus.]]></summary_hr><summary_en><![CDATA[The aim of the project is to obtain a new approach to bifurcation theory. We study dynamical systems, in particular singular perturbations, fractal geometry, complex analysis, and numerical modeling of dynamical systems. Qualitative theory studies solutions of equations without explicitly solving the equations. These equations naturally depend on parameters, so we study the bifurcation theory, where bifurcation means a qualitative change in the behavior of a system. A system undergoing a bifurcation can change stability, which is a crucial problem in mathematical modeling. The famous unsolved 16th Hilbert problem asks for a uniform upper bound on the number of limit cycles for a given polynomial vector field.  Limit cycles can be born from bifurcations, and also in singular perturbations of the system.  In this project our innovative approach is reading properties of bifurcations of dynamical systems from the measure A(fr,E), and from the fractal zeta functions Z(fr,E) of E-neighborhoods of orbits of the system fr,  depending on parameter r. A fractal dimension called the box dimension, is determined from the leading term of the asymptotic expansion of E –> A(fr,E) but other terms also give important information about the system. Complex analysis and the Mellin transform are the main tools in the construction of zeta functions Z(fr,E). Furthermore, new numerical methods for detecting bifurcations based on the fractal approach will be developed. These methods will include GPU based numerical computations, nonlinear optimization, and fine sampling of the bifurcation parameter space. Limit cycles born in singular perturbations, often called canards, will be considered using box dimension and fractal zeta function methods to obtain the cyclicity of the canard cycles. The Canard phenomenon is the phenomenon where for a small parameter the limit cycle created in a Hopf bifurcation stays of “small size” for a while, but then it changes very rapidly to a “big size” cycle.]]></summary_en></project><project>
<id>8212</id><title_hr><![CDATA[Kontrola kvalitete proteina putem selektivne razgradnje u stanicama u mirovanju]]></title_hr><title_en><![CDATA[Degradation-mediated protein quality control in quiescent cells]]></title_en><user_id>20884</user_id><user_firstLast_name>Mirta Boban</user_firstLast_name><svouser_id>25651</svouser_id><svouser_firstLast_name>Antonio Bedalov</svouser_firstLast_name><proposal_type>PZS</proposal_type><proposal_call>2019-02</proposal_call><code>PZS-2019-02-3610</code><acronim><![CDATA[Q-CTRL]]></acronim><duration>01.01.2020 - 31.05.2023</duration><status>Završio</status><financ_value>247.594,68 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>11124, 25651, 25387, 23233, 855795, 865158, </team_members_id><team_members_names><![CDATA[Goran Šimić, Antonio Bedalov, Klara Zubčić, Marija Renić, Dina Franić, Mihaela Pravica, ]]></team_members_names><keywords_hr><![CDATA[neurodegeneracija, starenje, proteinski agregati, misfolding, ubikvitin, proteasom, stanično mirovanje]]></keywords_hr><keywords_en><![CDATA[neurodegeneration, aging, protein aggregates, misfolding, ubiquitin, proteasome, quiescence]]></keywords_en><summary_hr><![CDATA[Održavanje proteoma jedan je od najvažnijih zadataka stanice. Nakupljanje proteinskih agregata povezano je s procesom starenja i neurodegeneracije, primjerice u Alzheimerovoj bolesti. Kako bismo rasvijetlili uzrok bolesti, važno je razumjeti na koji način se zdrava stanica nosi s problemom agregacije proteina. Kako bi spriječile nakupljanje oštećenih proteina, stanice su razvile sofisticirani sustav za kontrolu kvalitete proteina (KKP), koji uključuje selektivnu razgradnju terminalno oštećenih proteina pomoću ubikvitin-proteasoma. Molekulski putevi KKP evolucijski su konzervirani od kvasca do čovjeka. Mnoge stanice u ljudskom organizmu, poput neurona, ne proliferiraju. Za razliku od proliferirajućih stanica, koje se mogu riješiti oštećenja asimetričnom diobom, ne-proliferirajuće stanice ne posjeduju ovu mogućnost. U ovom projektu cilj nam je istražiti specifičnosti KKP u ne-proliferirajućim stanicama, te ispitati utjecaj starenja na ove molekulske puteve KKP.  Kako bismo rasvijetlili ova pitanja, koristit ćemo stanični model relevantan za proučavanje ne-proliferirajućih stanica te starenja, mirujuće stanice kvasca Saccharomyces cerevisiae. Zanimljivo je da su proteasomi u ovim stanicama re-organizirani u citoplazmatske granule, te trenutno nije jasno jesu li ovi proteasomi aktivni.  U predloženim projektu ispitat ćemo predstavljaju li oštećeni proteini u mirujućim stanicama supstrat za selektivnu razgradnju sustavomu ubikvitin-proteasoma, ili drugih molekulskih puteva. Nadalje, ispitat ćemo jesu li misfolded protein mofdificirani ubikvitinom, te ako da, koji molekulski putevi su uključeni. Također ćemo ispitati na koji način starenje utječe na ove procese. Vjerujemo kako će rasvjetljavanje puteva kontrole kvalitete proteina u mirujućim stanicama kvasca doprinijeti razumijevanju kontrole kvalitete proteina u ne-proliferirajućim ljudskim stanicama, kao što su neuroni, te razumijevanju kako ove stanice sprečavaju nakupljanje oštećenih proteina i nastanak agregata.]]></summary_hr><summary_en><![CDATA[Maintaining a functional proteome is one of the major tasks of the cell. Increased levels of protein aggregates are associated with aging and neurodegeneration, such as in Alzheimer’s and Parkinson’s disease. A key to understanding the cause of the disease is elucidating how a functional cell deals with the problem of protein misfolding and aggregation.To prevent accumulation of damaged proteins, cells have developed intricate network of protein quality control (PQC) pathways, including selective degradation of terminally damaged proteins by the ubiquitin-proteasome system (UPS). Notably, pathways of degradation-mediated PQC are highly conserved from yeast to man. Many cells in the human body, such as neurons, are non-dividing. In contrast to proliferating cells, which can clear the damage by asymmetric cell division, non-dividing cells lack this possibility. In this project, we wish to address the specificities of degradation-mediated PQC in non-dividing cells, and examine how these pathways are affected by aging. To this end, we chose a model that is relevant for non-dividing cells and suitable for studying aging, quiescent yeast Saccharomyces cerevisiae. Intriguingly, in quiescent cells, proteasomes re-localize from the nucleus into the cytoplasmic storage granules, and it is presently unclear whether those proteasomes are active. Specifically, we will test whether misfolded proteins in quiescent cells are selectively targeted for degradation by the UPS or other pathways, in addition to known pathway of bulk autophagy. Furthermore, we will examine whether misfolded proteins are modified by ubiquitin, and if yes, by which pathways. Finally, we will test how these processes are affected by chronological aging. We believe that elucidating the protein quality control in quiescent yeast cells will contribute to understanding how non-dividing mammalian cells, such as neurons, prevent accumulation of misfolded proteins, therefore preventing formation of aggregates.]]></summary_en></project><project>
<id>8215</id><title_hr><![CDATA[2D i kvazi-2D perovskiti: od ciljanog strukturnog dizajna do poboljšane učinkovitosti i stabilnosti]]></title_hr><title_en><![CDATA[Exploring halide 2D and quasi-2D perovskites: from rational structural design to enhanced efficiency and stability]]></title_en><user_id>11146</user_id><user_firstLast_name>Jasminka Popović</user_firstLast_name><svouser_id>25460</svouser_id><svouser_firstLast_name>Aleksandra Djurisic</svouser_firstLast_name><proposal_type>PZS</proposal_type><proposal_call>2019-02</proposal_call><code>PZS-2019-02-2068</code><acronim><![CDATA[2DQ2DPEROEXPLORE]]></acronim><duration>01.10.2019 - 31.05.2023</duration><status>Završio</status><financ_value>281.899,26 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, Fizika, </scie_field_hr><scie_field_en>Chemistry, Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>24947, 25534, 13002, 13189, 855358, 21308, </team_members_id><team_members_names><![CDATA[Ivor Lončarić, Luca Grisanti, Martina Vrankić, Željko Skoko, Juraj Ovčar, Lidija Kanižaj, ]]></team_members_names><keywords_hr><![CDATA[2D perovskites, Ruddlesden-Popper, Dion-Jacobson, optical properties, crystal structure, theoretical calculations]]></keywords_hr><keywords_en><![CDATA[2D perovskiti, Ruddlesden-Popper, Dion-Jacobson, optička svojstva, kristalna struktura, teorijski izračuni]]></keywords_en><summary_hr><![CDATA[Hibridni 3D perovskiti trenutno predstavljaju jedno od najaktivnijih polja istraživanja zbog ogromnog potencijala u solarnim ćelijama i svjetlosnim diodama. Performanse perovskitnih solarnih ćelija rasle su strelovitom brzinom, dostižući učinkovitosti veće od 23%. No, njihova komercijalizacija trenutno je sputana uslijed nedovoljne stabilnoti. Alternativa 3D perovskitima nedavno je predložena: na pitanje nedovoljne stabilnosti mogu odgovoriti perovskiti niže dimenzionalnosti, konkretno 2D Ruddlesden-Popper (A2A&#39;n-1BnX3n+1) i Dion-Jacobson (AA&#39;n-1BnX3n+1)  perovskti gdje je A&#39; je manji organski kation koji može formirati 3D perovskitni sloj, B je dvovalentni metal, najčešće Pb2+, X=I- ili Br-, n je debljina anorganskog perovskitnog slojeva, A je veliki organski kation, tkz. razmaknica ili spacer). Perovskiti nižih dimenzija mogu se smatrati kao samo-slagajuće višestruke kvantne jame, gdje su eksitoni ograničeni na anorganske „jame“ a organske razmaknice služe kao potencijalne barijere. Zbog njihove specifične strukture ovi materijali omogućuju jednostavno ugađanje ciljanih optičkih svojstava i veću stabilnost u odnosu na 3D analoge no, s druge strane, zadovoljavajuća učinkovitost nije postigunta, ponajviše zbog nedovoljnog razumijevanja odnosa kemijskog sastava, strukturnih značajki i rezultirajućih svojstava. Zbog toga je izuzetno važno primjeniti sinergijski pristup, kombinacijom eksperimentalnih istraživanja i teorijskih proračuna, koji će brže i djelotvornije ispitivati odnos između kemijskog/kristalnog inženjeringa i rezultirajućih svojstava. Takav pristup rasvjetljavjetliti će međuigru između jedinstvenih fizičkih svojstava 2D i kvazi-2D perovskita (eksitonska svojstva, elektron-fonon vezanje, i sl..), odabira perovskitnih građevnih jedinica, rezultirajuće kristalne strukture i orijentacije, optičkih svojstva te, konačno, poboljšanih optoelektričnih performansa solarnih ćelija i svjetlosnim diodama sastavljenih od 2D i kvazi-2D perovskita.]]></summary_hr><summary_en><![CDATA[ Hybrid perovskites are currently one of the most active fields of research due to their huge potential for applications in solar cells (SCs) and light-emitting diodes (LEDs). The performances of perovskite SCs have increased at an incredible rate, reaching efficiencies exceeding 23%. However, the commercialization is hindered by their poor stability. Very recently, low-dimensional 2D perovskites (Ruddlesden-Popper (RP) with formula A2A’n-1BnX3n+1 or Dion-Jacobson (DJ) with formula AA’n-1BnX3n+1) have been identified as promising alternatives to 3D perovskites. In those compounds, A is a large organic spacer cation, A’ is a smaller organic cation capable of forming 3D perovskite slab, B is a divalent metal (commonly Pb2+), X is halide anion, and n is number of inorganic perovskite layers.  Lower dimensional perovskites can be considered as self-assembled multiple-quantum-wells, with excitons confined in inorganic “wells”, while the organic spacers serve as potential barriers. Due to their chemical structure, these materials offer better tunability and higher stability compared to their 3D counterparts, but they suffer from reduced efficiency and insufficient understanding of the relationships between their chemical structure and their properties. Consequently, the progress in exploring huge realm of possible compounds in this category is proceeding mainly by trial and error. In contrast, this project proposes a comprehensive study on 2D and quasi-2D perovskites, by tackling the chemical/crystal engineering, detailed structural/physical property measurements and state-of-the-art theoretical approaches and computing. It will lead to elucidation of relationship between the unique physical properties of 2D perovskites (excitonic properties, electron–phonon coupling, etc.), the choice of perovskite building blocks and resulting crystal structure and orientation, optical properties and optoelectronic performances, thus extending the realm of SCs and LEDs applications.]]></summary_en></project><project>
<id>8220</id><title_hr><![CDATA[Mehanizmi nastajanja snopova mikrotubula potrebni za sazrijevanje diobenog vretena]]></title_hr><title_en><![CDATA[Mechanisms of microtubule bundle formation required for spindle maturation]]></title_en><user_id>11207</user_id><user_firstLast_name>Iva Tolić</user_firstLast_name><svouser_id>25529</svouser_id><svouser_firstLast_name>Marin Barisic</svouser_firstLast_name><proposal_type>PZS</proposal_type><proposal_call>2019-02</proposal_call><code>PZS-2019-02-7653</code><acronim><![CDATA[SpindleForm]]></acronim><duration>01.11.2019 - 31.10.2022</duration><status>Završio</status><financ_value>291.990,18 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>6276, 3581, 861477, 866276, 866270, </team_members_id><team_members_names><![CDATA[Nenad Pavin, Juraj Simunić, Mateja Ćosić, Isabella Koprivec, Valentina Štimac, ]]></team_members_names><keywords_hr><![CDATA[diobeno vreteno, mikrotubuli, proteini koji povezuju mikrotubule, motorni proteini, kinetohore]]></keywords_hr><keywords_en><![CDATA[mitotic spindle, microtubules, crosslinking proteins, motor proteins, kinetochores]]></keywords_en><summary_hr><![CDATA[Tijekom mitoze stanica formira diobeno vreteno koje simetrično razdvaja kromosome u dvije stanice kćeri. Diobeno vreteno sastoji se od nekoliko klasa mikrotubula, uključujući kinetohorna vlakna koja se vežu na kromosome putem kinetohora i preklapajuće ili interpolarne snopove antiparalelnih mikrotubula koji rastu iz suprotnih polova vretena. Za funkciju vretena potrebna je precizna prostorna organizacija snopova mikrotubula i kinetohora, koja je dobro opisana za metafazno vreteno. Međutim, tijekom prometafaze mikrotubuli su neravnomjerno raspoređeni na području budućeg metafaznog vretena, dok kinetohorna vlakna i preklapajući snopovi još nisu vidljivi. Središnje je pitanje kako se tijekom prometafaze neravnomjerno raspoređeni mikrotubuli preraspoređuju u dobro odijeljene i pravilno organizirane snopove koji smještaju kinetohore u metafaznu ploču. Naši početni pokusi pokazuju da se broj preklapajućih snopova povećava tijekom prometafaze i da novi snopovi mogu nastati uzdužnim cijepanjem postojećih. Da bismo analizirali molekularne mehanizme nastanka snopova, razvit ćemo pristup temeljen na novim humanim staničnim linijama dobivenima CRISPR metodom, koje ćemo proučavati pomoću konfokalne i superrezolucijske mikroskopije. Da bismo identificirali ključne proteine u formiranju snopova, modificirat ćemo ekspresiju proteina kandidata: kinetohornih proteina, motornih proteina i nemotornih proteina koji povezuju mikrotubule. Razvit ćemo i optogenetički pristup za uklanjanje proteina iz vretena, kao i pristup temeljen na bioaktivnim peptidima koji mijenjaju brzinu motornih proteina. Također ćemo identificirati mjesta nastanka kinetohornih vlakana i preklapajućih snopova te njihove detirozinacije, kao i vrijeme njihova formiranja i interakcije. Ovaj će projekt otkriti kako nastaju snopovi mikrotubula koji čine složenu arhitekturu zrelog metafaznog vretena.]]></summary_hr><summary_en><![CDATA[During mitosis, the cell forms a spindle that segregates chromosomes symmetrically into two daughter cells. The mitotic spindle consists of several classes of microtubules, including kinetochore fibers that interact with chromosomes via kinetochores, and overlap or interpolar bundles that consist of antiparallel microtubules extending from the opposite spindle poles. A precise spatial organization of microtubule bundles and kinetochores is necessary for spindle function, and it has been to a large extent described for a metaphase spindle. However, during prometaphase, microtubules are unevenly distributed over the area of the future metaphase spindle, whereas kinetochore fibers and the associated overlap bundles are not yet evident. A central question is how during prometaphase these unevenly distributed microtubules become rearranged into discrete well-organized bundles, which position kinetochores into the metaphase plate. Interestingly, our pilot experiments show that the number of overlap bundles increases during prometaphase, and that new bundles can form by lateral splitting of the existing ones. To dissect the molecular mechanisms of bundle formation, we will develop an approach based on new CRISPR-edited human cell lines, which will be studied by live-cell confocal and superresolution microscopy. To identify key molecular players in bundle formation, we will modify the expression of candidate kinetochore proteins, motor proteins, and non-motor microtubule crosslinkers. Moreover, we will develop an optogenetic approach to remove a crosslinker protein from the spindle, and an approach based on bioactive peptides to modulate motor velocity. Finally, we will identify the sites of kinetochore fiber and overlap bundle formation and detyrosination, as well as the time of their formation and interaction. This project will reveal how microtubule bundles form, giving rise to the highly organized architecture of the mature metaphase spindle.]]></summary_en></project><project>
<id>8224</id><title_hr><![CDATA[Inteligentni računalni procesi za predikciju, otkrivanje i razumijevanje u genomici i farmakogenomici]]></title_hr><title_en><![CDATA[Augmented intelligence workflows for prediction, discovery and understanding in genomics and pharmacogenomics]]></title_en><user_id>3806</user_id><user_firstLast_name>Tomislav Šmuc</user_firstLast_name><svouser_id>1421</svouser_id><svouser_firstLast_name>Fran Supek</svouser_firstLast_name><proposal_type>PZS</proposal_type><proposal_call>2019-02</proposal_call><code>PZS-2019-02-8525</code><acronim><![CDATA[AIGEN]]></acronim><duration>01.11.2019 - 30.04.2023</duration><status>Završio</status><financ_value>207.923,55 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, Interdisciplinarne tehničke znanosti, </scie_field_hr><scie_field_en>Computer sciences, Interdisciplinary technological sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>22813, 25586, 865308, </team_members_id><team_members_names><![CDATA[Matej Mihelčić, Jurica Levatić, Davor Oršolić, ]]></team_members_names><keywords_hr><![CDATA[multi-modalni podaci, fuzija informacija i modela, interpretabilnost, interakcije, genske funkcije, prokarioti, fenotip, rak, stanične linije]]></keywords_hr><keywords_en><![CDATA[multi-modalni podaci, fuzija informacija i modela, interpretabilnost, ineractions, gene function, prokaryotic, phenotype, cancer, cell line]]></keywords_en><summary_hr><![CDATA[Inteligentni računalni procesi za predikciju, otkrivanje i razumijevanje u genomici i farmakogenomiciAlgoritmi iz područja dubokog učenja i učenja reprezentacija iz podataka postali su  standard za prediktivne modele bazirane na multimodalnim podatacima. No njihova prediktivna moć praćena je velikom kompleksnošću modela i reprezentacija, a time i gubitkom interpretabilnosti. Za većinu istraživačkih problema u bioznanostima interpretabilnost model jednako je važna kao i prediktivna moć.Cilj ovog projekta je premostiti jaz između prediktivne moći i interpretabilnosti odnosno razumijevanja. Projekt će kombininrati istraživanja novih računalnih procesa za razvoj kompleksnih dubokih mreža iz multi-modalnih podataka za prediktivne modele, sa proširenjima i razvojem novih algoritama za alternativnog opisivanje podataka. Novo razvijene funkcionalnosti omogućit će učinkovito multi-modalno rudarenje podataka i otkrivanje  interpretabilnih asocijacija iz  podataka, kao i interpretaciju složenih dubokih  modela odnosno reprezentacija. Novo razvijeni računalni procesi će se primijeniti u okviru tri složena problema u označavanju i predviđanju iz genomike i farmakogenomike. Projekt će imati impakt na istraživanja u računarstvu, računalnoj biologiji, genomici i preciznoj medicini. Imat će važan impakt i na karijere mladih znanstvenika koji će se educirati kroz istraživanja u interdisciplinarnom okruženju, kao i na ukupnu vidljivost istraživačke skupine,  te sposobnosti za dobivanje kompetitivnih projekata na međunarodnoj razini.]]></summary_hr><summary_en><![CDATA[Augmented intelligence workflows for prediction, discovery and understanding in genomics and pharmacogenomicsRecent algorithmic developments in the area of deep learning and representation learning have become de-facto standard for predictive problems in multi-modal data settings. Advantageous predictive performance of comes with a cost: typically very complex models and a loss of interpretability. For most of the research problems in bio-sciences interpretability is equally important as predictive power.This project aims to bridge this prediction-understanding by combining developments in predictive computational workflows based on deep learning and graph embedding approaches with extensions of the state-of-the-art redescription mining framework, which will provide means for efficient multi-modal pattern mining and association discovery from omics data, as well as explanation of complex representation fusion models. This developments will be showcased and validated on three complex annotation and prediction problems from genomics and pharmacogenomics. The project aims to make impact on research in computer science, computational biology, genomics and precision medicine. It will have an impact on careers of young scientists who will receive research based education in an interdisciplinary setting, as well as for the overall visibility of research group, and its propensity and capacity for competitive projects on an international level.  ]]></summary_en></project><project>
<id>8231</id><title_hr><![CDATA[IZAZOVI FINANCIJSKOG I NEFINANCIJSKOG IZVJEŠTAVANJA JEDINICA JAVNOG SEKTORA  U KONTEKSTU PROMJENJIVIH ZAHTJEVA KORISNIKA INFORMACIJA]]></title_hr><title_en><![CDATA[CHALLENGES OF FINANCIAL AND NON-FINANCIAL REPORTING BY PUBLIC SECTOR ENTITIES IN THE CHANGING USER NEEDS ENVIRONMENT]]></title_en><user_id>7294</user_id><user_firstLast_name>Vesna Vašiček</user_firstLast_name><svouser_id>7069</svouser_id><svouser_firstLast_name>Nives Botica Redmayne</svouser_firstLast_name><proposal_type>PZS</proposal_type><proposal_call>2019-02</proposal_call><code>PZS-2019-02-5372</code><acronim><![CDATA[REPINPUBSEC]]></acronim><duration>01.10.2019 - 31.05.2023</duration><status>Završio</status><financ_value>238.967,42 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, </scie_field_hr><scie_field_en>Economy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Ekonomski fakultet u Zagrebu]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Economics and Business]]></institution_en><team_members_id>2956, 7104, 7230, 7095, 25597, 855444, 29318, </team_members_id><team_members_names><![CDATA[Davor Vašiček, Gorana ROJE, SANJA BROZ TOMINAC, MARTINA DRAGIJA KOSTIĆ, Josip Čičak, Matko Ljubić, Ivana Pajković, ]]></team_members_names><keywords_hr><![CDATA[računovodstvo javnog sektora, financijsko, nefinancijsko i integrirano izvještavanje, korisnici informacija, javni menadžment, financijsko upravljanje]]></keywords_hr><keywords_en><![CDATA[public sector accounting, financial, nonfinancial and integrated reporting, information users, public management, public sector financial management]]></keywords_en><summary_hr><![CDATA[Istraživanje na ovom projektu usmjereno je na dva komplementarna područja Računovodstvo i financijsko izvještavanje jedinica javnog sektora (JS): kako odgovoriti izazovu promjenjivih i rastućih zahtjeva korisnika informacija?, i Integrirano izvještavanje kao novi izazov za jedinice JS i odgovor na integrirano razmišljanje. Prvo područje fokusirano je na pozicioniranje aktualnog sustava proračunskog računovodstva u RH u odnosu na primjenu modela obračunske osnove, u kontekstu sve većih zahtjeva  brojnih korisnika za  računovodstveno – financijskim informacijama jedinica JS za razne svrhe, kao i zahtjeva šireg okruženja i globalizacijskih procesa koji teže ujednačavanju i standardizaciji informacija i ispitivanju korisnosti informacija. Slijedom toga, uz uvažavanje specifičnosti hrvatskog javnog sektora, cilj je istražiti najbolje prakse s uspješno provedenom reformom računovodstva JS (s naglaskom na primjeru Novog Zelanda) i ukazati na moguće varijante reforme računovodstva i financijskog izvještavanja jedinica JS  u RH.Drugo područje, ima za cilj istražiti mogućnosti primjene integriranog izvještavanja koje pored financijskog izvještavanja uključuje i nefinancijsko izvještavanje te predstavlja novi izazov, ali i veliki potencijal za korištenje u jedinicama JS. Namjera je u okviru projekta odgovoriti na istraživačko pitanje u kojoj mjeri su elementi integriranog izvještavanja prisutni u normativnom okviru u RH i u praksi izvještavanja jedinica JS u RH te koji se poticaji i prepreke razvoju integriranog izvještavanja mogu detektirati u RH. Uvažavajući primjere međunarodne dobre prakse u primjeni izvještavanja o nefinancijskim informacijama u jedinicama JS namjera je ukazati na izbor mogućih varijanti integriranog izvještavanja primjenjiv u JS u  RH.Dodatno se naglašava aplikativni značaj ovih istraživanja koji može biti koristan regulatornim tijelima u RH (prvenstveno Ministarstvu financija), ali i međunarodnim tijelima u primjeni IPSAS –a ili EPSAS-a u EU.    ]]></summary_hr><summary_en><![CDATA[The aim of this study is two-fold, as the study addresses two complementary topics with expressed mutual conditionality and influences. Firstly, it explores the existing system of public sector (PS) accounting and reporting by public sector entities and challenges of its further development, with the attempt to identify growing requirements for gathering accounting- financial information of PS entities for various reporting purposes, and the attempt to explore the impact of the international environment and globalization processes demands striving for uniformed and standardized information in a set of a wider PS financial management and accounting reform processes. Thus, the focus of this study is to explore the usefulness of implementing accrual accounting in the PS, by looking at advanced countries practices (i.e. New Zealand) and the possibilities of developed countries PS accounting reform experiences’ and wider international trends’ application in Croatian PS accounting system, taking into consideration the respective national specifics. The applicative significance of this research shall be most useful to regulatory bodies in Croatia (primarily the MoF), but also to international standard setters in the field of the ongoing and future application of IPSAS/EPSAS.  Secondly, the study explores the new, advanced and internationally recognized means of reporting - the integrated reporting as the challenge ahead of PS entities, which combines both the financial and non-financial reporting and hence represents a means of reporting of a high potential use by the PS entities. The intention is to explore to what extent the elements of the integrated reporting are present in the existing regulatory framework in Croatia, as well as in the reporting practice by PS entities, and what are the drivers and obstacles to the development of integrated reporting in the Croatia.Lastly the study purports to explore the interface between two aforementioned research areas. ]]></summary_en></project><project>
<id>8232</id><title_hr><![CDATA[Jednoslojni polarimetar gama zračenja za primjene u medicinskom oslikavanju i za temeljna istraživanja u fizici]]></title_hr><title_en><![CDATA[Single layer gamma-ray polarimeter for medical imaging applications and fundamental physics research]]></title_en><user_id>1479</user_id><user_firstLast_name>Mihael Makek</user_firstLast_name><svouser_id>25566</svouser_id><svouser_firstLast_name>Zdenka Kuncic</svouser_firstLast_name><proposal_type>PZS</proposal_type><proposal_call>2019-02</proposal_call><code>PZS-2019-02-5829</code><acronim><![CDATA[SiLGaP]]></acronim><duration>01.10.2019 - 31.05.2023</duration><status>Završio</status><financ_value>291.532,28 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>3809, 4413, 22715, 20067, 855376, 864949, 858418, 866738, 4395, </team_members_id><team_members_names><![CDATA[Damir Bosnar, Petar Žugec, Luka Pavelić, Darko Grošev, Ana Marija Kožuljević, Om prakash Dash, Tomislav Bokulić, Siddharth Parashari, Ivica Friščić, ]]></team_members_names><keywords_hr><![CDATA[Scintilacijski detektori, polarizacija gama zračenja, komptonsko oslikavanje, pozitronska emisijska tomografija, kvantna sprega]]></keywords_hr><keywords_en><![CDATA[Scintillation detectors, Gamma polarization, Compton imaging, Positron emission tomography, Quantum entanglement]]></keywords_en><summary_hr><![CDATA[Informacija o polarizaciji gama zračenja je važna u mnogim područjima suvremenih istraživanja u fizici. U području fundamentalnih istraživanja primjer je fenomen kvantne sprege, kojeg je moguće proučavati analiziranjem relativnih polarizacija tri gama fotona iz raspada orto-pozitronija. U području primjena, važan je slučaj biomedicinsko oslikavanje pomoću pozitronske emisijske tomografije (PET), gdje su simulacijske studije pokazale da polarizacijska informacija, koje se ne koristi u dostupnim PET sustavima, ima potencijal poboljšati kvalitetu slike. Polarizacija gama fotona se može odrediti putem Comptonova raspršenja, koje rezultira rapršenim elektronom i raspršenom gama česticom.  Za rekonstrukciju Comtponovih raspršenja potrebni su pozicijski i energijski osjetljivi detektori, koji se obično sastoje od dva sloja, prvog za detekciju elektrona i drugog za detekciju raspšenog fotona. No, u mnogim primjenama gdje su detektori izrazito segmentirani i sadrže velik broj kanala, kao u PET-u, sustav utemeljen na dvoslojnim detektorima imao bi relativno visoku cijenu. U ovom projektu napravit ćemo novi, modularni sustav za mjerenje polarizacije gama fotona, utemeljen na jednoslojnim detektorima za mjerenje Comptonova raspšrenja. Pojedini modul će se sastojati od matrice scintilacijskih detektora, iščitavanih silicijskim fotomultiplikatorima. U usporedbi sa dvoslojnim sustavima, ovaj koncept nudi mogućnost konstrukcije cjenovno povoljnijih, kompaktnih i višenamjenskih uređaja.  U projektu ćemo postaviti sustav od šesnaest modula, koji će se primijeniti u dva istraživanja. U prvom će se po prvi put eksperimentalno ispitati mogućnost korištenja informacija o polarizaciji gama zračenja u PETu, kao važan korak prema novoj generaciji efikasnijih uređaja za medicinsko oslikavanje. U drugom će analizirati azimutalne korelacije tri gama fotona iz raspada orto-pozitronija, da bi se istražila kvantna sprega, kao temeljni fizikalni koncept.]]></summary_hr><summary_en><![CDATA[Gamma-ray polarization information is valuable in many areas of contemporary physics research. An example in fundamental sector is the phenomenon of quantum entanglement, which may be investigated by analyzing relative polarizations of three gammas originating from ortho-positronium decay. In applications, an important case is the biomedical imaging with Positron Emission Tomography (PET), where it has been shown by simulated model studies, that the polarization information, which is not exploited in existing PET systems, has the potential to improve the image quality. The polarization of a gamma photon can be determined from its Compton scattering, where it produces a recoil electron and a scattered photon. For reconstruction of Compton events, one needs position and energy-sensitive detectors, usually encompassing two layers, for detection of the electron and the scattered photon, respectively. However, in many applications where detectors are highly granular and contain many channels, such as PET, a system based on two-layer readout would be costly.  In this project we will construct a new, modular detector system for gamma polarization measurements, based on single-layer Compton scattering detectors. A module will contain an array of scintillators, read-out by silicon photomultipliers. Compared to two-layer detectors, the single-layer concept offers a possibility to construct more cost-efficient, compact and versatile devices. We will assemble a sixteen-module system, which will be used in two applications: first, to evaluate experimentally for the first time the feasibility of using the information about gamma-ray polarization in PET, as an important step towards the next generation of more efficient medical imaging devices, and second, to analyze the azimuthal correlations of three gammas from ortho-positronium decay in order to investigate entanglement as a fundamental concept of quantum physics.]]></summary_en></project><project>
<id>8233</id><title_hr><![CDATA[Fotonaponska-geopolimerna fasada: uloga vode-kisika u naprednom sklapanju filmova kompozitnih materijala]]></title_hr><title_en><![CDATA[Photovoltaic-geopolymer facade: the water-oxygen role in the advanced assembly of layered composite materials ]]></title_en><user_id>1338</user_id><user_firstLast_name>Vilko Mandić</user_firstLast_name><svouser_id>3023</svouser_id><svouser_firstLast_name>Neven Ukrainczyk</svouser_firstLast_name><proposal_type>PZS</proposal_type><proposal_call>2019-02</proposal_call><code>PZS-2019-02-1555</code><acronim><![CDATA[PV-WALL]]></acronim><duration>01.10.2019 - 31.05.2023</duration><status>Završio</status><financ_value>291.921,83 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Kemijsko inženjerstvo, </scie_field_hr><scie_field_en>Chemical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet kemijskog inženjerstva i tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Chemical Engineering and Technology]]></institution_en><team_members_id>25552, 25553, 25515, 25542, 25512, 22641, 25503, 2766, 25567, 3932, 25518, 3421, 12630, 1333, 23211, 3971, 1362, 863809, </team_members_id><team_members_names><![CDATA[Thomas Rath, Gregor Trimmel, Chicot Didier, Roudet Francine, Uroš Cvelbar, Ivana Panžić, Franz-Josef Haug, Stanislav Kurajica, Igor Jajčinović, Milivoj Plodinec, Louis Ghislain, Luka Pavić, Ivan Brnardić, Juraj Šipušić, Zrinka Švagelj, Dragana Vuk, Maja Buljan, Marko Rukavina, ]]></team_members_names><keywords_hr><![CDATA[Fotonaponski-geopolimerni kompozit, Pametna fasada, Prozirni vodljivi oksid, Materijali za prinos naboja, Upravljanje iskorištavanjem energije]]></keywords_hr><keywords_en><![CDATA[PV-Geopolymer-Composite, Smart Facade, Transparent Conducting Oxide, Charge Transfer Materials, Energy Harvesting Management]]></keywords_en><summary_hr><![CDATA[Građevine najviše pridonose energetskim gubicima, na temelju čega otvaraju prostor za uštede u energiji na svjetskoj razini. Upravljanje energijom u građevinama može se doskočiti pomoću inovacija u području konstrukcijskih materijala. Cilj projekta je korištenje veziva, tj. priprava geopolimerne paste (GP) u vodljivoj i/ili prozirnoj konfiguraciji, sličnoj materijalima prozirnih vodljivih oksida (TCO), kako bi se istražila mogućnost primjene takvih materijala u solarnim ćelijama (SC).TCO materijali su važni za osiguranje površinskog vodljivosti u nizu optoelektroničkih sustava. Ovaj projekt za cilj ima izbjeći uobičajeno oštećivanje slojeva korištenjem mekih metoda depozicije (kemijske, ablacija iskrom, itd.), te termičke obrade i hidrogeniranja, bez narušavanja svojstva prozirnosti i vodljivosti. Moderne SC sadrže samo slojeve oksida za prijenos naboja (CTO) u nanostrukturiranoj konfiguraciji. Cilj projekta je proširiti postojeće znanje o povezivanju nanostrukturiranih TCO i CTO slojeva, kako bi se omogućilo bolje razumijevanje njihove stabilnosti. Naime, kontaktiranje filmova/površina u operativne SC predstavlja glavne izazove u razvoju zadnje generacije fotonaponskih uređaja. Projektu će istražiti pripravljanje SC temeljenih na: 1) silicijevom heterospoju (cilj: unaprjeđenje periferije i stoga povećanje efikasnosti/stabilnosti), 2) hibridno organskom višefaznom heterospoju (cilj: nova sinteza, kontrola spektra absorpcije i stabilnosti), te 3) fotoaktivnim perovskitima (cilj: isprobati miješanu višefaznu fotoabsorpciju, unaprjeđenja stabilnosti).Na temelju saznanja o umrežavanju GP te sklapanju SC, cilj je pokušaj izvedbe kompozita GP-SC, kao dokaza izvedivosti.Cilj je maksimalno uključiti mlade istraživače (ESR), koristiti metode koje nisu dostupne ili prigodne u Hrvatskoj, razviti novu metodu, osigurati široku diseminaciju, time povećati vidljivost istraživačke grupe, uključenih institucija i financijera, te potaknuti interes industrije za rezultate projekta.]]></summary_hr><summary_en><![CDATA[Buildings are the main contributors to energy-losses, so they offer margin for global energy savings. Buildings energy management can be addressed by innovations in the construction materials. We aim to use emerging binder; the geopolymer (GP) paste and prepare it in conducting and/or transparent configuration, much like the transparent conducting oxides (TCO) materials, to research the possibility of utilising such materials in solar cells (SC). TCO are important for lateral current transport in many optoelectronic systems. This project aim is to avoid or mitigate the common damage to the layers by the use of softer deposition methods (chemical, spark ablation, etc.), or annealing, or hydrogenation, but still provide conductivity and transparency. In modern SC, only charge transfer oxides (CTO) have been applied in nanostructural configuration. The aim is to expand the knowledge on interfacing of nanostructurised TCO & CTO layers, to investigate their stability to atmosphere conditions. Namely, further interfacing, i.e. the issues in assembly of the layers into operative SC contribute to mayor challenges of the last-generation of energy-harvesting technology. SC will comprise following photo-absorbing layers: 1) silicon heterojunction (aim: upgrade periphery, thus stability/efficiency increase), 2) bulk-heterojunction hybrid-organic (aim: novel synthesis, thus tailoring of stability and absorption spectra) and 3) photoactive perovskite (aim: try co-absorbing, thus stability advancements). On behalf of a GP polymerisation engineering knowledge and SC layer interfacing findings we aim an attempt to incorporate GP in SC, as a proof-of-concept.Aim is to maximise inclusion of Early Stage Researchers (ESR), use equipment not available or up to date in Croatia, to develop new technique, broadly disseminate results findings, increase international visibility of research Group, Institutions involved and Funding body and reach-out to industrial stakeholders.]]></summary_en></project><project>
<id>8235</id><title_hr><![CDATA[Globalni Humanizmi: Novi Pogledi na Srednji Vijek (300- 1600)]]></title_hr><title_en><![CDATA[Global Humanisms: New Perspectives on the Middle Ages (300-1600)]]></title_en><user_id>5939</user_id><user_firstLast_name>Miljenko Jurković</user_firstLast_name><svouser_id>25537</svouser_id><svouser_firstLast_name>Zrinka Stahuljak</svouser_firstLast_name><proposal_type>PZS</proposal_type><proposal_call>2019-02</proposal_call><code>PZS-2019-02-1624</code><acronim><![CDATA[GLOHUM]]></acronim><duration>01.11.2019 - 28.02.2023</duration><status>Završio</status><financ_value>291.990,18 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Povijest umjetnosti, Filologija, Povijest, Arheologija, </scie_field_hr><scie_field_en>Art history, Philology, History, Archeology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>2704, 25671, 7684, 5797, 6957, 839, 23876, 4762, 6063, 6260, 6375, 5523, 24133, 855891, 855892, 856225, 24009, </team_members_id><team_members_names><![CDATA[Danijel Dzino, Slavko  Kacunko, Neven  Budak, Predrag Marković, Dino Milinović, Marijan Bradanović, Goran Bilogrivić, Nikola Jakšić, Ivan Josipović, Jean-Pierre  Caillet, Xavier Barral i Altet, Vincenza Lucherini, Pascale Chevalier, Palmira Krleža, Ivor Kranjec, Filip Lovrić, Jelena Behaim, ]]></team_members_names><keywords_hr><![CDATA[globalni humanizmi, srednjovjekovni humanizmi, srednjovjekovne renesanse, dvorska umjetnost, srednji vijek u dugom trajanju]]></keywords_hr><keywords_en><![CDATA[global humanisms, medieval humanisms, medieval renaissances, the art of the court, the long lasting middle ages (longue duree)]]></keywords_en><summary_hr><![CDATA[Teza je pokazati da je humanizam već srednjovjekovni koncept, koji se manifestira u nizu renesansi, a ne invencija s početka ranog novog vijeka. Cilj je  ponuditi novu i drugačiju povijest srednjega vijeka, koja se rigoroznom i metodičkom primjenom interdisciplinarnog pristupa odmiče od ograničenja tradicionalne periodizacije. Umjesto „mračnog srednjeg vijeka“ nudi se vizija humanističkog srednjeg vijeka u „dugom trajanju“ (300-1600). Istraživanja potvrđuju teorijsku utemeljenost ideje da se kroz djela „dvorske umjetnosti“ manifestira niz renesansi (Konstantinova, Teodozijeva, Sixtova, Justinijanova, Teodolindina, Liutprandska, Karolinška, Otonska, renesansa 11. st., pa 12. st., stil 1200., rana gotika, vernakularni stil), pokazujući da se antički „humanizmi“ prenose djelovanjem intelektualnih elita. Ciljevi su ispitati tezu dijakronijski, kroz razdoblja od kasne antike do gotike, istražiti je i povezati kroz različite vidove umjetničkog izraza: pisane riječi, likovnih umjetnosti, arhitekture i urbanizma. Metodološki pristup u rasponu je od terenskog (arhivski rad, rekognosciranje, snimanje, katalogizacija građe, 3D rekonstrukcije) do komparativnog (renesanse u europskom prostoru). Potom će se dobivene rezultate povezati da bi se razvio model sekvenciranja srednjovjekovnih renesansi. U metodološkom smislu  interdisciplinarnost je ključna.Rezultati spoznaja će se istovremeno primijeniti na tradicionalno razdoblje renesanse 16. st., koju bismo mogli označiti kao kulminaciju svih prethodnih. Projekt time uključuje globalnu, izvan-europsku dimenziju renesanse, jer će se pažnja usredotočiti na transatlantski, habsburški imperij.Očekivani je rezultat unaprijediti saznanja o srednjem vijeku u dugom trajanju. Dodatni učinci proizlaze iz korištenja novih tehnologija - sve će biti dostupno korisnicima, službama zaštite spomenika, lokalnim zajednicama na istraživanim prostorima, za edukaciju i bolje donošenje odluka u očuvanju kulturne baštine.]]></summary_hr><summary_en><![CDATA[The thesis is to show that “humanism” is already a medieval notion and not an invention of early modernity. The goal is to write “a history of the Middle Ages” - one possible new, different history. A rigorous and methodological interdisciplinary approach intends to emancipate it from the constraints of traditional periodization. Instead of a dark Middle Ages, a humanistic Middle Ages, spanning the late antiquity and the Classical Age. Research has proven that, through the works of the “Arts of the Court,” there existed a sequence of renaissances (Constantine’s, Theodosian, Sixtus’, Justinan’s, Theodolinda’s, Liutprand’s, Carolinginan, Ottonian, Renaissance of 11th C., Renaissance of 12th C., The Style 1200, Early Gothic, Vernacular Style), evidence that Classical “humanisms” are translated through the actions of intellectual elites. The goal is to test the hypothesis diachronically, through all periods from Late Antiquity to Gothic, and synchronically through means of artistic expression: the written word, visual arts, architecture and urbanism. The methodological approach ranges from field research (work in archives, territory survey, recording, cataloguing, 3D) to comparative analysis of renaissances in Europe. Data and results will be merged to develop a model of sequencing medieval renaissances. Here an interdisciplinary approach is essential to the methodology. These findings will also be applied to the traditionally defined period of the 16th c. Renaissance, seen as the culmination of all the preceding ones. The project therefore includes an extra-European, global dimension for the Renaissance by focusing on the trans-Atlantic, Habsburg empire.The expected result is to improve our knowledge of the medieval period in the longue durée. The additional impact stems from the use of new technologies: all data will be available to users, heritage protection offices, and local communities in order to educate and to improve the decision making in CH preservation.]]></summary_en></project><project>
<id>8241</id><title_hr><![CDATA[Mehanokemijske i bezotopinske strategije za sintezu funkcionalnih poroznih materijala s naprednim fizičko-kemijskim i katalitičkim svojstvima]]></title_hr><title_en><![CDATA[Mechanochemical and solvent-free strategies towards functional porous materials with advanced physico-chemical and catalytic properties]]></title_en><user_id>280</user_id><user_firstLast_name>Krunoslav Užarević</user_firstLast_name><svouser_id>13224</svouser_id><svouser_firstLast_name>Tomislav Friscic</svouser_firstLast_name><proposal_type>PZS</proposal_type><proposal_call>2019-02</proposal_call><code>PZS-2019-02-4129</code><acronim><![CDATA[MECHADVANCE]]></acronim><duration>01.11.2019 - 31.01.2023</duration><status>Završio</status><financ_value>291.757,91 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>23293, 24360, 25645, 25568, 25639, 23120, 25569, 13551, 88, 25668, 25673, 864960, 865409, 29530, 21344, </team_members_id><team_members_names><![CDATA[Bahar Karadeniz, Tomislav Stolar, Vladislav Kataev, Blaž Likozar, Yulia Krupskaya, Senada Muratović, Venkata D B C  Dasireddy, Igor Dejanović, Aleksandar Sabljić, Tomislav Mrla, Vlatka Vraneša, Mihails Arhangelskis, Ivana Brekalo, Valentina Martinez, Katarina Lisac, ]]></team_members_names><keywords_hr><![CDATA[Mehanokemija, kemija čvrstog stanja, porozni materijali, odnos strukture i svojstava,  metalo-organske mreže, organski porozni materijali]]></keywords_hr><keywords_en><![CDATA[Mechanochemistry, solid-state chemistry, porous materials, structure-properties relationship, metal-organic frameworks, organic porous materials]]></keywords_en><summary_hr><![CDATA[Glavni cilj ovog prijedloga projekta je proširiti suradnju između dvije jake istraživačke skupine s komplementarnim vještinama, one iz McGill-a i skupine RBI, te razviti istraživačku mrežu i metodologiju za istraživanje bezotopinskih metoda, kao što su mehanokemija i ubrzano starenje, kao platforme za sintezu i modifikacije relevantnih metal-organskih mreža (MOF), njihovih nekonvencionalnih derivata i organskih poroznih materijala. Pokušat ćemo iskoristiti mehanokemiju i termalnu aktivaciju za pripremu amorfnih i staklenih faza ovih materijala, što je jedna od relevantnijih tema u suvremenoj kemiji materijala, i proučavati kako smanjenje unutrašnjeg uređenja utječe na njihove fizičko-kemijske osobine i potencijalnu primjenjivost (magnetizam, fluorescencija, osjetljivost, kataliza, poroznost i termička i kemijska stabilnost).Ovaj će se projekt posebno usredotočiti na zapošljavanje i razvoj mladih istraživača u skladu sa smjernicama EU-a za horizontalne teme u zemljama Europe. Oni će biti uključeni u svaki aspekt realizacije i pružiti će im se jedinstvena prilika za razvoj u dinamičnom poticajnom okruženju unutar istraživačke mreže izgrađene na temelju ovog projekta, koje osim McGilla i RBI-a uključuje tri druge institucije iz Hrvatske, Slovenije i Njemačke. Predloženi rad poslužit će za proširenje postojeće jake suradnje između Sveučilišta McGill i Instituta Ruđer Bošković te omogućiti razmjenu iskustava i znanja kroz razmjenu studenata i posjeta istraživača iz dviju institucija. Nova planirana instrumentacija je jedinstvena za ustanovu, i također će poslužiti za jačanje domaćeg istraživačkog potencijala. S obzirom da sćemo razviti nove instrumenate i materijala, očekujemo da će projekt imati snažnan učinak na sintetske pristupe u laboratoriju, ali i da imaju snažan potencijal za komercijalizaciju i ekonomskog napretka i provedbe u kemijskoj industriji.]]></summary_hr><summary_en><![CDATA[The main objective of this project proposal is to extend the collaboration between two strong research groups with complementary skills, the one from McGill and the RBI group, and develop research network and methodology for exploring solvent-free methods, such as mechanochemistry and accelerated aging, for synthesis and modifications of relevant metal-organic frameworks (MOFs), their derivatives, and organic porous materials. We will try to exploit mechanochemistry and thermal activation for preparing also the amorphous and glass phases of these materials, which is one of the most relevant topics in modern materials chemistry, and study how the reduction of internal ordering is affecting their physicochemical properties and applicability (magnetism, fluorescence, sensing, catalysis, porosity, and thermal and chemical stability). This project will be focused particularly on employing and development of young researchers in accordance with the guidance of the EU for horizontal themes in the south and eastern Europe. They will be included in every aspect of its realization and provided with an opportunity to develop in dynamic and innovative environments of both research groups, and inside of the research network built on the basis of this project, that beside McGill and RBI involves three other institutions from Croatia, Slovenia, and Germany. The proposed work will serve to extend the existing strong collaboration between McGill University and Ruđer Bošković Institute and enable the exchange of experience and knowledge through students-exchange and visits between the researchers from two institutions. The new instrumentation will serve to strengthen domestic research potential. As we will develop new instrumentation and materials, we expect the project to have a strong effect on solid-state reactivity in a laboratory, but also to have the potential for commercialization and economic prosperity and implementation in chemical industry.]]></summary_en></project><project>
<id>8242</id><title_hr><![CDATA[Sinteza naprednih nanočestica i primjene u fotokatalizi i tekstilnim materijalima]]></title_hr><title_en><![CDATA[Synthesis of advanced nanoparticles and applications in photocatalysis and textile materials]]></title_en><user_id>1271</user_id><user_firstLast_name>Nikša Krstulović</user_firstLast_name><svouser_id>25572</svouser_id><svouser_firstLast_name>Eva  Kovacevic </svouser_firstLast_name><proposal_type>PZS</proposal_type><proposal_call>2019-02</proposal_call><code>PZS-2019-02-5276</code><acronim><![CDATA[NanoCaTex]]></acronim><duration>01.10.2019 - 30.09.2022</duration><status>Završio</status><financ_value>277.455,17 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, Interdisciplinarne prirodne znanosti, </scie_field_hr><scie_field_en>Physics, Interdisciplinary natural sciences, </scie_field_en><institution_hr><![CDATA[Institut za fiziku]]></institution_hr><institution_en><![CDATA[Institute of Physics in Zagreb]]></institution_en><team_members_id>23343, 17797, 25634, 6722, 25572, 865330, 865353, 866588, </team_members_id><team_members_names><![CDATA[Damjan Blažeka, Dean Popović, Andrea Jagodar, SANJA ERCEGOVIĆ RAŽIĆ, Eva  Kovacevic , Rafaela Radičić, Tea Kaurin Kaurin, Dejan Maletić, ]]></team_members_names><keywords_hr><![CDATA[plazmene tehnologije, laserska sinteza nanočestica, metalne nanočestice, kataliza, biorazgradivost, tekstilni materijali]]></keywords_hr><keywords_en><![CDATA[plasma technology, laser synthesis of nanoparticles, metallic nanoparticles, catalysis, biodegradation, textile amterials]]></keywords_en><summary_hr><![CDATA[Plazmene tehnologije poprimaju sve veće zanimanje i značenje u razvoju naprednih materijala nove generacije zbog svojih jedinstvenih svojstava, široke primjene i učinkovitosti djelovanja. Obrada materijala pomoću plazme sve se više koristi u industrijskim, tehnoloških i medicinskim primjenama. Ovaj projekt se zasniva na laserskoj inovativnoj sintezi koloidnih otopina nanočestica, obradi tekstilnih materijala pomoću atmosferskog plazmenog mlaza i njihovim primjenama u razvoju fotokatalize i razvoju tekstilnih materijala s poboljšanim antimikrobnim svojstvima, boljom UV zaštitom i boljom biorazgradivošću.]]></summary_hr><summary_en><![CDATA[Plasma technologies today are taking attention in the development of emerging advanced materials of new generation due of its unique properties, broadness of applications and effectiveness of treatment. Plasma processing of materials is increasingly used in industrial, technological and medical applications. This project is based on innovative laser synthesis of colloidal nanoparticle solutions, treatment of textile materials with atmospheric pressure plasma jet (APPJ) and their applications in photocatalysis and in development of textile materials with improved antimicrobial activity, UV protection and biodegradation. ]]></summary_en></project><project>
<id>8249</id><title_hr><![CDATA[Učinci višestrukih stresora na biološku raznolikost i funkcije slatkovodnih ekosustava]]></title_hr><title_en><![CDATA[Effects of multiple stressors on freshwater biodiversity and ecosystem functioning  ]]></title_en><user_id>20412</user_id><user_firstLast_name>Ana Previšić</user_firstLast_name><svouser_id>3680</svouser_id><svouser_firstLast_name>Mira Petrovic</svouser_firstLast_name><proposal_type>PZS</proposal_type><proposal_call>2019-02</proposal_call><code>PZS-2019-02-9479</code><acronim><![CDATA[MUSE]]></acronim><duration>01.11.2019 - 31.05.2023</duration><status>Završio</status><financ_value>224.014,20 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Interdisciplinarne prirodne znanosti, Kemija, Biologija, </scie_field_hr><scie_field_en>Interdisciplinary natural sciences, Chemistry, Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>12890, 25563, 25623, 25627, 25628, 13634, 858403, 858400, 865412, </team_members_id><team_members_names><![CDATA[Marko Rožman, Graf Wolfram, Vitecek Simon, Zlatko Mihaljević, Andreja Brigić, Antun Alegro, Marina Veseli, Iva Kokotović, Filip Ložek, ]]></team_members_names><keywords_hr><![CDATA[višestruki stresori, slatkovodna bioraznolikost, funkcije ekosustava, DNA barkodiranje, spektrometrija masa]]></keywords_hr><keywords_en><![CDATA[multiple stressors, freshwater biodiversity, ecosystem functioning, DNA barcoding, mass spectrometry]]></keywords_en><summary_hr><![CDATA[Posljednja znanstvena dostignuća prepoznaju sve veći utjecaj višestrukih stresora na vodna tijela u Europi, što rezultira velikim promjenama bioraznolikosti, funkcija i usluga slatkovodnih ekosustava. S druge strane, učinci stresora na bioraznolikost vrsta ostaju uglavnom neotkriveni korištenjem viših taksonomskih kategorija u biomonitoringu. Slično tome, razumijevanje bioakumulacije i biomagnifikacije onečišćivača (npr. farmaceutski aktivnih spojeva, endokrinih disruptora, mikroplastike) u hranidbenim mrežama je nepotpuno. Nadalje, postoji malo podataka o prijenosu onečišćivača iz vodenih u kopnene hranidbene mreže. Sukladno tome, ovaj projekt ima za cilj unaprijediti naše znanje o učincima višestrukih stresora na: I) bioraznolikost slatkovodnih ekosustava, te na II) funkcije slatkovodnih ekosustava i povezanost vodenih i kopnenih staništa. Kako bi se ostvarili navedeni ciljevi, provesti će se terenska istraživanja i laboratorijski pokusi. Predloženo istraživanje unaprijediti će razumijevanje odgovora pojedinih vrsta i populacija na stresore u okolišu primjenom suvremenih alata, tj. DNA barkodiranja. Posljednja dostignuća spektrometrije masa koristiti će se za proučavanje profila metabolita te identifikaciju i kvantifikaciju onečišćivača u tkivima organizama. Očekivani rezultati dati će važan doprinos poznavanju uloge različitih predstavnika pojedinih trofičkih nivoa u putovima prijenosa onečišćivača kroz hranidbene mreže i ekosustave. Uspostavom suradnje sa svjetski poznatim znanstvenikom iz vodećeg europskog istraživačkog instituta i tri dodatne europske znanstvene institucije, mobilizirat će se jedinstvena kombinacija vještina i multidisciplinarnog znanja za provedbu projektnih aktivnosti. Sukladno tome, osim jačanja kapaciteta hrvatskih znanstvenika i institucija, očekujemo da će rezultati ovog istraživačkog plana imati značajan utjecaj na istraživanje slatkih voda.]]></summary_hr><summary_en><![CDATA[Current state-of-the-art research identifies Europe’s water bodies influenced by a complex mixture of stressors. As a result, biodiversity, ecosystem functions and services of the freshwaters are changing at an unprecedented rate. Impacts of stressors on species remain undetected when taxa are merged to a higher taxonomic level for biomonitoring. Similarly, understanding of bioaccumulation and biomagnification of emerging contaminants (ECs, e.g. pharmaceuticals, endocrine disrupting compounds, microplastics) in aquatic food webs are incomplete. Furthermore, there are only few studies on transfer of ECs to terrestrial ecosystems through the vital aquatic-terrestrial habitat linkage (ATHL). Accordingly, this project aims at advancing our knowledge on effects of multiple stressors on: I) freshwater biodiversity and II) ecosystem functioning and ATHL. Objectives will be approached by combining field-based research and laboratory mesocosm experiments. The proposal aims on providing novel insights into species- and lineage-specific responses to environmental stressors through application of the DNA barcoding method. Furthermore, the last generation analytical methods, such as hybrid and high resolution mass spectrometry, will be used to study metabolomic profiles and to detect ECs in biota samples. Anticipated results will provide essential links necessary for evaluation of routes and mechanisms of ECs transfer through food webs and ecosystems and for development of more realistic biomagnification scenarios. By establishing collaboration with world known scientist from a leading European water research institute and 3 additional European scientific institutions, unique combination of skills, expertise and knowledge will be mobilised to carry out the project activities. Accordingly, besides capacity building of Croatian scientists and institutions, the results produced by this innovative research plan will have substantial impact on the field of inland water research.]]></summary_en></project><project>
<id>8274</id><title_hr><![CDATA[Višerazinsko numeričko modeliranje i eksperimentalno istraživanje procesa starenja u sinteriranim konstrukcijskim komponentama]]></title_hr><title_en><![CDATA[Multiscale Numerical Modelling and Experimental Investigation of Ageing Processes in Sintered Structural Components]]></title_en><user_id>3311</user_id><user_firstLast_name>Zdenko Tonković</user_firstLast_name><svouser_id>20193</svouser_id><svouser_firstLast_name>Nenad Gubeljak</svouser_firstLast_name><proposal_type>PZS</proposal_type><proposal_call>2019-02</proposal_call><code>PZS-2019-02-4177</code><acronim><![CDATA[MultiSintAge]]></acronim><duration>01.11.2019 - 30.04.2023</duration><status>Završio</status><financ_value>290.640,72 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, </scie_field_hr><scie_field_en>Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>927, 263, 1039, 2803, 25641, 25621, 25648, 855836, 855835, </team_members_id><team_members_names><![CDATA[Jurica Sorić, Tomislav Jarak, Ivica Skozrit, Tomislav Lesičar, Krešimir Vučković, Ivan Čular, Srečko Glodež, Zoran Tomić Tomić, Tomislav Polančec, ]]></team_members_names><keywords_hr><![CDATA[starenje materijala i konstrukcija, numeričko modeliranje, eksperiment, višerazinska analiza, sinterirani materijal, zupčanik, zamor, rupičenje]]></keywords_hr><keywords_en><![CDATA[ageing of materials and structures, numerical modelling, experiment, multiscale analysis, sintered material, gear, fatigue, pitting]]></keywords_en><summary_hr><![CDATA[Upotreba materijala s naprednim svojstvima koji posjeduju visoku učinkovitost uz prihvatljive troškove je ključni detalj u razvoju modernih konstrukcija i strojnih dijelova. U sustavima prijenosa snage, upotreba tehnologije sinteriranih materijala pokazala je znatne prednosti u odnosu na klasičnu metalurgiju zbog relativno niskih cijena proizvodnje, ekološke prihvatljivosti, visokog udjela iskoristivosti sirovina i dobre redukcije buke u eksploataciji. U ovom projektu se proučavaju sinterirani zupčanici, koji imaju potencijal da u budućnosti postanu ključni elementi u sustavima prijenosa snage. Nosivost zupčanika je općenito ograničena raznim mehanizmima starenja konstrukcija, kao što je zamor u korijenu zuba uslijed savijanja zuba ili zamor uslijed pojave pitinga na boku zuba. U sinteriranim čelicima, pore u međudjelovanju uzrokuju lokalizaciju deformacija dok izolirane pore uvjetuju sveukupno deformiranje u materijalu. Za pouzdano predviđanje kolapsa konstrukcija uslijed zamora u numeričkim analizama iznimno je važno obuhvatiti i oštećenje u mikrostrukturi materijala. Takav način modeliranja još uvijek predstavlja veliki izazov u numeričkoj mehanici, s nizom neriješenih problema.Opći cilj projekta MultiSintAge je razvoj numeričkog pristupa za modeliranje starenja konstrukcija izrađenih od sinteriranog čelika uslijed zamora. U okviru projekta bit će provedena eksperimentalna istraživanja na mikro- i makro-razini kako bi se validirali razvijeni višerazinski numerički modeli. Za razliku od postojećih numeričkih pristupa za analizu cjelovitosti sinteriranih konstrukcija, u numeričkim modelima razvijenima u sklopu ovog projekta materijalna svojstva sinteriranog materijala na makro-razini bit će dobivena modeliranjem ponašanja materijala na mikro-razini, pri čemu će biti korišteni odgovarajući nelokalni numerički modeli i homogenizacijske procedure.]]></summary_hr><summary_en><![CDATA[The application of complex materials with enhanced properties that achieve high efficiency at acceptable cost is a key issue in developing modern structures and machine components. In mechanical power transmissions of today, the powder metallurgy (PM) technology has shown considerable advantages over the conventional metallurgy due to relatively low manufacturing costs, environmental friendliness, a high utilization rate of material and a good noise reduction in exploitation. Here, sintered gears, which might become key components of mechanical power transmission in future machines, are considered. The gear load bearing capacity is limited by different kinds of ageing mechanisms, such as the bending fatigue in tooth root or pitting at teeth flank. In the sintered steel, interconnected pores cause strain localizations between particles, while isolated porosity induces overall deformations. To accurately predict a failure during the ageing process due to the fatigue, a detailed numerical analysis incorporating damage at the microstructural level is of great importance, which still represents a challenge in scientific community, with many unanswered questions. The overall objective of the MultiSintAge project is the development of a computational framework for modelling the ageing of structures made of sintered steel subjected to fatigue loading conditions. Experimental investigations at the macroscopic and microscopic level will be performed to validate developed multi-scale computational models. In contrast to the existing numerical approaches for analysing structural integrity of sintered components, in the developed numerical methods the material properties of a sintered material at the macro-level will be obtained by means of material modelling at the microstructural level, whereby appropriate nonlocal numerical models and homogenization procedures will be used.]]></summary_en></project><project>
<id>8287</id><title_hr><![CDATA[Vlakna i proteini kao osnova za razvoj novih bioaktivnih dodataka hrani]]></title_hr><title_en><![CDATA[Fibers and proteins as building blocks for development of novel bioactive food ingredients]]></title_en><user_id>7246</user_id><user_firstLast_name>Mirela Kopjar</user_firstLast_name><svouser_id>7330</svouser_id><svouser_firstLast_name>Josip Simunovic</svouser_firstLast_name><proposal_type>PZS</proposal_type><proposal_call>2019-02</proposal_call><code>PZS-2019-02-1595</code><acronim><![CDATA[NovelBioactives]]></acronim><duration>01.10.2019 - 30.04.2023</duration><status>Završio</status><financ_value>251.343,82 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Prehrambena tehnologija, </scie_field_hr><scie_field_en>Food technology, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Prehrambeno-tehnološki fakultet]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Food Technology]]></institution_en><team_members_id>7296, 25600, 25662, 4090, 866629, </team_members_id><team_members_names><![CDATA[Anita Pichler, Vanja Kelemen, Josipa Vukoja, Indira Kosović, Ivana Buljeta, ]]></team_members_names><keywords_hr><![CDATA[Vlakna, proteini, fenoli, aroma, novi bioaktivni dodatci hrani]]></keywords_hr><keywords_en><![CDATA[Fibers, proteins, phenol, flavor, novel bioactive food ingredients]]></keywords_en><summary_hr><![CDATA[  Sve su veći zahtjevi potrošača za svježim, prirodno funkcionalnim prehrambenim proizvodima koji imaju odgovarajuću nutritivnu vrijednost ali i pozitivan učinak na zdravlje. Drugi rastući trend je povećanje zahtjeva potrošača za prikladnim proizvodima koji pojednostavljuju pripremu obroka i njegovu konzumaciju i omogućuju „healthy snacking“ u i izvan kuće. Ovaj trend je posebice potaknut modernim, brzim i mobilnim načinom života. Iz tih razloga se znanstvenici sve vise fokusiraju na razvoj novih dodataka hrani s potencijalnim pozitivnim učinkom na zdravlje. S druge strane, potrebna su dodatna istraživanja usmjerena na utjecaj tih dodataka na kvalitetu proizvoda u koji se dodaju. Prehrambena vlakna, proteini i fenoli vezani su uz mnoge pozitivne učinke na zdravlje te je stoga preporučen povećani unos navedenih komponenata. Zbog već spomenutog pozitivnog učinka na zdravlje, ove komponente se mogu koristiti individualno ili u kombinacijama kao dodatci prehrambenim proizvodima. Osim nutritivne vrijednosti i pozitivnog učinka na zdravlje, vlakna, protein i fenoli doprinose i senzorskim i tehnološkim svojstvima hrane, tako da njihovo kompleksiranje predstavlja dodatnu vrijednost prilikom formuliranja novih bioaktivnih dodataka.    Glavni cilj ovog projekta je razvoj i testiranje novih bioaktivnih dodataka hrani pripremljenih na osnovi vlakana i proteina. Novoformulirani bioaktivni dodatci hrani mogu se koristiti kao dodatci u mliječne i pekarske proizvode, te proizvode na bazi voća i povrća. Novina ovog istraživanja je formuliranje novih kombinacija protein/fenol, vlakna/fenol i protein/vlakna/fenol kompleksa. Dodatno, vrlo važan aspekt ovog istraživanja je razvoj bioaktivnih dodataka primjenom mikrovalova, dodatka trehaloze i kombinacije trehaloze i mikrovalova, odnosno tehnika koje do sada nisu bile korišten za formuliranje polimer/fenol kompleksa.]]></summary_hr><summary_en><![CDATA[Consumer demand is on the rise for fresh, healthy and naturally functional food products which provide both nutritional and health related benefits. Another emerging trend is the rising demand for convenience foods to simplify meal preparation and consumption and provide healthy snacking options in and outside of homes. This trend is driven by the rapidly changing modern, busy and mobile lifestyles. Therefore, researchers have been focusing on development of novel food ingredients with health benefits, however, additional research is needed to concentrate on the effects of these ingredients on the quality of resulting food products.  Dietary fibers, proteins and phenolic compounds are associated with numerous health benefits, thus increasing their intake is highly recommended. These ingredients can be used individually or in combinations as food additives to enrich foods and provide health benefits to consumers. In addition to their nutritional and health benefits, fibers, proteins and phenolics contribute to the sensory and technological properties of foods, so their association could be an additional justification for preparation of novel bioactive ingredients. The main objective of this project is development and testing of novel bioactive food ingredients using fibers, proteins and phenolics as building blocks. These novel bioactive ingredients can be used as additives for dairy, fruit, vegetable and bakery products. The novelty aspect of this research is the preparation of new combinations of protein/phenol, fiber/phenol and protein/fiber/phenol complexes. Additionally, very important part of this study is enhanced development of bioactive ingredients by applications of microwave treatments, addition of trehalose, and combinations of trehalose and microwave treatments which are the tools which have not been applied previously in preparation of polymer/phenolic complexes.]]></summary_en></project><project>
<id>8288</id><title_hr><![CDATA[Glikozilacija proteina u bolestima povezanim sa starenjem kroz istraživanje preuranjenog starenja u Downovom sindromu]]></title_hr><title_en><![CDATA[Protein glycosylation in ageing-related diseases through study of Down syndrome as accelerated ageing condition]]></title_en><user_id>5420</user_id><user_firstLast_name>Gordan Lauc</user_firstLast_name><svouser_id>25615</svouser_id><svouser_firstLast_name>Dean Nizetic</svouser_firstLast_name><proposal_type>PZS</proposal_type><proposal_call>2019-02</proposal_call><code>PZS-2019-02-4277</code><acronim><![CDATA[GlycoDown]]></acronim><duration>01.10.2019 - 31.05.2023</duration><status>Završio</status><financ_value>291.990,18 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[GENOS d.o.o. ]]></institution_hr><institution_en><![CDATA[GENOS Ltd ]]></institution_en><team_members_id>25522, 25644, 855367, 26383, 862781, 865331, 12653, </team_members_id><team_members_names><![CDATA[Jasminka Krištić, Frano Vučković, Dražen Juraj Petrović, Ana Cindrić, Helena Deriš, Thomas Klarić, Dinko Mitrečić, ]]></team_members_names><keywords_hr><![CDATA[Glikozilacija proteina, Downov sindrom, starenje, Alzheimerova bolest, inducirane pluripotentne matične stanice]]></keywords_hr><keywords_en><![CDATA[Protein glycosylation, Down Syndrome, Ageing, Alzheimer’s Disease, induced pluripotent stem cells]]></keywords_en><summary_hr><![CDATA[Hrvatska (i cijela Europa) imaju vrlo nepovoljne demografske trendove. Oni uključuju porast udjela starog stanovništva i povećanje učestalosti bolesti povezanih sa starenjem. Nedavno je istraživačka grupa Prof. Lauca pokazala da je obrazac glikozilacije imunoglobulina G (IgG) dobar biomarker kronološke dobi, biološkog starenja te sistemske upale.Downov sindrom (DS) (trisomija 21 (T21)) uzrokuje izrazito ubrzano starenje na razini stanica i organizma kao cjeline te stoga predstavlja odličan sustav za proučavanje ubrzanog starenja. Ipak, značajni broj osoba s DS je zaštićen od bolesti povezanih sa starenjem, kao što je Alzheimerova demencija (AD). Prof. Nižetić je međunarodno prepoznati istraživač u proučavanju DS, a njegova grupa je nedavno napravila novi izogenski model induciranih pluripotentnih matičnih stanica (iPSC) za DS.Glikozilacija proteina nije do sada bila sistematično istraživana u kontekstu Downovog sindroma (DS). Naši preliminarni podaci dobiveni analizom uzoraka plazme 10 osoba s DS su nakon usporedbe s podacima zdravih osoba koje su im odgovarale po dobi pokazali da vrijednosti za neke IgG glikane značajno odskaču u osoba s DS, ukazujući da je pokazatelje ubrzanog starenja moguće detektirati analiziranjem poremećaja u glikomu u DS.Ciljevi: (i) odrediti glikozilaciju IgG u Downovom sindromu (DS) analiziranjem 300 osoba s DS iz tri europske populacije. Napravit će se i analiza vezana uz komorbiditete koji se javljaju uz DS, osobito rani ili kasni/bez razvoj(a) AD; (ii) istražiti utjecaj određenih genskih produkata kromosoma 21 na glikozilacijski profil; (iii) ustanoviti utjecaj T21 na glikanski profil usporedbom isogenskih iPSC-ova koji se razlikuju samo po prisutnosti T21; (iv) analizirati potencijal glikanskih biomarkera u predviđanju rane AD usporedbom glikanskog profila iPSC-ova (i dobivenih neurona) dobivenih iz uzoraka osoba s DS s ranom demencijom (u njihovim 30-ima) i osoba s DS bez demencije u dobi >60 godina.]]></summary_hr><summary_en><![CDATA[Croatia (and the whole of Europe) are suffering from the most unfavourable demographic trends They include high population-ageing rates and an increasing incidence of age-related diseases. Recently, Prof. Lauc’s team discovered that immunoglobulin G (IgG) glycome pattern is an accurate biomarker of chronological and biological ageing, as well as systemic inflammation.Down’s Syndrome (DS) (trisomy 21 (T21)) causes extremely accelerated cellular and organism ageing and is therefore an excellent model of accelerated ageing. However, despite this, significant cohorts of people with DS are protected from ageing-related diseases, such as Alzheimer’s dementia (AD). Prof. Nižetić is an internationally leading researcher in DS and his team recently developed a new isogenic induced pluripotent stem cell (iPSC) model of DS.Protein glycosylation has never been systematically studied in the context of Down Syndrome. In our preliminary data from plasma samples of 10 DS individuals, compared to age-matched euploids, we detected extreme values in several glycan forms of IgG, indicating that markers of extremely accelerated ageing can be detected by studying glycome perturbations in DS.Aims: i) determine glycosylation of immunoglobulin G (IgG) in Down Syndrome (DS) by analysing 300 individuals with DS from 3 European population. In addition, they will be analysed based on co-morbidities, in particular early or late/absent onset of AD; (ii) examine the effect of specific chromosome 21 gene products on the glycosylation profiles; (iii) establish the effects of T21 on glycan profiles by comparing isogenic iPSCs that differ only on the presence of T21; (iv) search for novel glycan biomarkers predictive of early AD by comparing same glycan profiles in iPSCs (and derived neurons) from DS subjects with early dementia (in their 30s) with DS subjects with no dementia at age >60.]]></summary_en></project><project>
<id>8294</id><title_hr><![CDATA[Siguran pristup za razvoj nano-sustava za ciljanu isporuku lijekova u mozak]]></title_hr><title_en><![CDATA[Safe-by-Design Approach for Development of Nano-Enabled-Delivery Systems to Target the Brain]]></title_en><user_id>573</user_id><user_firstLast_name>Ivana Vinković Vrček</user_firstLast_name><svouser_id>4882</svouser_id><svouser_firstLast_name>Frances Separovic</svouser_firstLast_name><proposal_type>PZS</proposal_type><proposal_call>2019-02</proposal_call><code>PZS-2019-02-4323</code><acronim><![CDATA[SENDER]]></acronim><duration>01.11.2019 - 31.05.2023</duration><status>Završio</status><financ_value>277.160,22 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Interdisciplinarne prirodne znanosti, Fizika, Kemija, Biologija, </scie_field_hr><scie_field_en>Interdisciplinary natural sciences, Physics, Chemistry, Biology, </scie_field_en><institution_hr><![CDATA[Institut za medicinska istraživanja i medicinu rada]]></institution_hr><institution_en><![CDATA[Institute for Medical Research and Occupational Health]]></institution_en><team_members_id>549, 25545, 25546, 29014, 858452, 21322, 25203, 865025, 866727, 5248, 11180, </team_members_id><team_members_names><![CDATA[Ivan  Pavičić, Marc-Antoine  Sani, Shiying Zhu, Nikolina Kalčec, Ivan Mamić, Maja Beus, Rinea Barbir, Nikolina Peranić, Vedran Dovečer, Zeljko Debeljak, Marija Ćurlin, ]]></team_members_names><keywords_hr><![CDATA[Nnaomedicina, nanosustavi za isporuku, krvno-moždana barijera, zlato, selen]]></keywords_hr><keywords_en><![CDATA[Nanomedicine, nanodelivery systems, blood-brain barrier, gold, selenium]]></keywords_en><summary_hr><![CDATA[Nanotehnologija omogućava inovativna i učinkovita terapijska i dijagnostička sredstva i alate. Ipak, liječenje neurodegenerativnih poremećaja još uvijek predstavlja veliki izazov zbog postojanja krvno-moždane barijere (BBB) koja otežava efikasnu dostavu lijeka u mozak. Multifunkcionalne nanočestice (NP) predstavljaju novu i poboljšanu platformu za veću učinkovitost, bioraspoloživost i ciljanu dostavu lijekova preko BBB. Stoga je glavni cilj predloženog projekta razviti multifunkcionalni nanosustav koji će omogućiti isporuku lijekova u mozak (BRaiND) za učinkovito i sigurno liječenje abnormalnosti mozga koja su povezana sa starenjem i degeneracijom. U tu svrhu provest će se specifične aktivnosti: - projektiranje, priprema i karakterizacija BRaiND ; - ocjenjivanje stabilnosti i sudbine BRaiND u biološkim medijima;- mehanička i kvantitativna procjena interakcije BRaiND sustava s BBB; - profiliranje učinkovitosti i sigurnosti BRaiND kombiniranim in vitro i in vivo pristupom.BRaiND će se temeljiti na nanočesticama selena ili zlata, stabiliziranih polietilen gilkolom i funkcionaliziranih proteinima koji ciljaju receptore mozga. Na takav multifunkcionalni sustav vezat će se modelni neuroaktivni lijekovi kako bi se demonstrirala učinkovitost, kvalitetu i sigurnost BRaiND sustava. Bit će provedena pažljiva in vitro i in vivo ispitivanja uključujući stabilnost i interakcije BRaiND-a u različitim biološkim medijima, prolaznost kroz BBB, djelotvornost ciljanja na specifična mjesta u mozgu, neuroprotektivnu aktivnost i procjenu sigurnosti njihove primjene. Radni plan projekta temelji se na validiranim i standardiziranim metodologijama, kao i na inovativnim eksperimentalnim tehnikama.Obzirom na glavne izazove translacijskih istraživanja neurodegenerativnih bolesti, strategija SENDER-a temelji se na Safe-by-Design pristupu, a omogućena je nanotehnološkim alatima koji analiziraju i manipuliraju biološkim procesima na nanoskali, gdje bolesti nastaju i napreduju.]]></summary_hr><summary_en><![CDATA[Nanotechnology paves the way for innovative and efficient therapeutic and diagnostic agents and tools. Still, treatment of neurodegenerative disorders remains a challenging field due to therapeutic necessity to reach the brain by crossing the blood-brain barrier (BBB), one of the best gate-keeper. Multifunctional nanoparticles (NPs) offer new and improved platform to solve issues about efficacy, bioavailability and targeting ability by translocating drugs through the BBB. The ultimate goal of proposed project is development of multifunctional nano-enabled drug delivery systems for brain (BRaiND) for efficient and safe treatment of abnormalities that follow debilitating brain conditions linked to aging and degeneration.  This will be achieved by following specific objectives:- design, preparation and characterization of BRaiND; - evaluation of BRaiND stability and fate in biological media; - mechanistic and quantitative assessment of interaction of BRaiND with BBB; - efficacy and safety profiling of BRaiND by a combined in vitro and in vivo approach.BRaiND will be based on selenium or gold NPs, stabilized with polyethylene gylcol and functionalized with proteins that target the brain receptors. Such multifunctionalized system will be loaded with model neuroactive agents to demonstrate its efficacy, quality and safety. Careful in vitro and in vivo testings will be performed including stability and interactions of BRaiND in different biological media, BBB permeability, efficacy of targeting specific brain sites, neuroprotective activity, and safety profiling. SENDER work plan is based on validated and standardized methodologies, as well as emerging new experimental techniques. Considering the major challenges of translational research in neurodegenerative diseases, SENDER strategy is based on the Safe-by-Design approach and enabled by nanotechnological tools that analyse and manipulate biological processes at the nanoscale, where diseases initiate and progress.]]></summary_en></project><project>
<id>8295</id><title_hr><![CDATA[ODRŽIVA GRADNJA NASUTIH PLAŽA – GRADNJA NOVIH I POVEĆANJE KAPACITETA POSTOJEĆIH]]></title_hr><title_en><![CDATA[SUSTAINABLE CONSTRUCTION OF ARTIFICIAL GRAVEL BEACHES-CONSTRUCTION OF NEW BEACHES AND AN INCREASE OF EXISTING CAPACITY]]></title_en><user_id>4885</user_id><user_firstLast_name>Dalibor Carević</user_firstLast_name><svouser_id>25660</svouser_id><svouser_firstLast_name>Suzana Ilic</svouser_firstLast_name><proposal_type>PZS</proposal_type><proposal_call>2019-02</proposal_call><code>PZS-2019-02-3081</code><acronim><![CDATA[BEACHEX]]></acronim><duration>01.11.2019 - 30.04.2023</duration><status>Završio</status><financ_value>268.944,92 eur</financ_value><scie_area_hr>Tehničke znanosti, Prirodne znanosti, </scie_area_hr><scie_area_en>Technological sciences, Natural sciences, </scie_area_en><scie_field_hr>Građevinarstvo, Geologija, Biologija, </scie_field_hr><scie_field_en>Civil engineering, Geology, Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Građevinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Civil Engineering]]></institution_en><team_members_id>18928, 6656, 25618, 25633, 4351, 13460, 25608, 5780, 28946, 22817, 855752, 855740, 858425, 865068, </team_members_id><team_members_names><![CDATA[Igor Ružić, Goran Lončar, Milvana  Arko-Pijevac, Čedomir Benac, Petar Kružić, Nino Krvavica, Mirjana  Kovačić, Kristina Pikelj, Filip Kalinić, Damjan Bujak, Duje Kalajžić, Tonko Bogovac, Andrea Tadić, Hanna Miličević Miličević, ]]></team_members_names><keywords_hr><![CDATA[dohrana plaža, nasipavanje plaža, erozija plaža, utjecaj nasipavanja na okoliš, utjecaj nasipavanja na biocenozu,baza podataka plaža ]]></keywords_hr><keywords_en><![CDATA[beach nourishment, beach filling, beach erosion, enviromental impact of filling, beach database]]></keywords_en><summary_hr><![CDATA[Hrvatske plaže su pod pritiskom turizma s jedne strane gdje se teži povećanju kapaciteta plaža te utjecaja klimatskih promjena s druge strane koje povećavaju erozijski potencijal olujnih valova. Na strateškoj razini, Hrvatska provodi osnovne mjere s ciljem učinkovitog upravljanja plažama ali u tom procesu nedostaje tehnička podrška. Upravo definiranje tehničke podrške za potrebe dugoročnog nasipavanja postojećih i novih žala u Hrvatskoj s minimalnim utjecajem na okoliš je cilj ovog projekta. U okviru projekta planira se izraditi sveobuhvatna baza lokacija (podataka) na kojima se vrši nasipavanje u svrhu povećanja kapaciteta plaža. Na bazi opsežnog terenskog mjerenja, planira se rasvijetliti morfološke procese na nasutim plažama u uvjetima jadranske valne klime te razviti jednostavan inženjerski alat za tehničke proračune (SHINGLE model). Utjecaj na okoliš, odnosno podmorsku biocenozu, će se istražiti kroz pet ronilačkih pregleda na plažama na kojima se vrši redovito nasipavanje. Primjenom numeričkog modeliranja definirat će se tehničke mjere potrebne da bi se dugoročno minimizirao gubitak materijala iz nasutih žala te mjere za umanjenje utjecaja klimatskih promjena. Edukacija relevantnih dionika (tehničko osoblje županija, gradova i općina) će se osigurati kroz provedbu dviju radionica u primorskim županijama. Diseminacija znanstvenih rezultata će se obaviti kroz publikaciju četiri znanstvena rada te pet konferencijskih izlaganja.]]></summary_hr><summary_en><![CDATA[Beaches in Croatia are under the pressure due to tourism development from one side which tends to growth the beach capacities and from the other side due to influence of climate changes which enlarge erosion potential of storm waves. At the strategic level, Croatia implements basic measures to effectively manage beaches but, in that process, technical support lacks. Definition of the technical support for the needs of long-term nourishing of the existing and filing of the new beaches in Croatia with minimal environmental impact is the goal of this project. Within the project it is planned to create a comprehensive database of sites where filling is used to apply along the Croatian coast. Based on the extensive field measurements, it is planned to research the morphological processes on the gravel beaches in wave conditions of the Adriatic Sea and to develop a simple engineering tool for technical calculations (SHINGLE model). The impact on the environment, i.e. on the underwater biocenosis, will be investigated through five dive examinations at beaches where regular nourishment takes place. Applying numerical modeling, the technical measures needed to minimize the loss of material from the beaches in long-term conditions will be defined and measures to mitigate the impact of climate changes. Education of relevant stakeholders (technical staff of counties, cities and municipalities) will be ensured through the implementation of two workshops in coastal counties. Dissemination of scientific results will be carried out through the publication of four scientific papers and five conference presentations.]]></summary_en></project><project>
<id>8302</id><title_hr><![CDATA[Istraživanje utjecaja metalnih promotora rijetkih zemalja i stupnja uređenja na redoks svojstva sustava CeO2 - ZrO2]]></title_hr><title_en><![CDATA[The study of the role of rare earth metal promoters and ordering on the redox properties of CeO2 - ZrO2 system]]></title_en><user_id>11136</user_id><user_firstLast_name>Igor Đerđ</user_firstLast_name><svouser_id>25703</svouser_id><svouser_firstLast_name>Aleksandar Miletic</svouser_firstLast_name><proposal_type>PZS</proposal_type><proposal_call>2019-02</proposal_call><code>PZS-2019-02-2467</code><acronim><![CDATA[SREMPOREPROCEZIS]]></acronim><duration>01.10.2019 - 31.05.2023</duration><status>Završio</status><financ_value>291.792,51 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, Fizika, </scie_field_hr><scie_field_en>Chemistry, Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Odjel za kemiju]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Department of Chemistry]]></institution_en><team_members_id>3960, 25573, 4128, 25200, 856292, </team_members_id><team_members_names><![CDATA[Berislav Marković, Aleksandar Sečenji, Sanja Petrušić, Jelena Kojčinović, Dalibor Tatar, ]]></team_members_names><keywords_hr><![CDATA[Trosmjerni katalizatori, Cerijev dioksid, Cirkonijev dioksid, Kapacitet pohrane kisika (OSC), Teorija funkcionala gustoće (DFT)]]></keywords_hr><keywords_en><![CDATA[Three-way catalysts, Ceria, Zirconia, Oxygen storage capacity, Density functional theory]]></keywords_en><summary_hr><![CDATA[Čvrsta otopina cerijevog (IV) oksida i cirkonijevog oksida (eng. Ceria-zirconia – CZ) naširoko se koristi u heterogenoj katalizi zbog svog izvanrednog svojstva za oslobađanje značajnih količina kisika u okoliš kroz redukciju Ce4+ u Ce3+ bez gubitka svoje prvobitne strukture. To se koristi, na primjer, u trosmjernim katalizatorima (eng. Three-way catalysts – TWC) u kontroli emisije plinova u benzinskim vozilima. U ovom ambicioznom kooperativnom projektu između Sveučilišta Josipa Jurja Strossmayera u Osijeku i Univerziteta u Novom Sadu, predlažemo istraživanje i objašnjenje međusobnih utjecaja CZ faze, aktivnog metala (Rh) iz skupine platinskih metala (eng. Platinum group metals – PGM), promotora, i kationa elemenata rijetkih zemalja kao što su La3+, Y3+, Pr3+/4+ također promotora, na redoks svojstva Ce4+/Ce3+. Kako bi se postigli ovako zahtjevni ciljevi, koristit će se napredne karakterizacijske metode za praćenje redukcije i oksidacije Ce i Rh pri reakcijskim uvjetima u reprezentativnim sintetskim TWC. Kinetika strukturnih promjena praćena različitim analitičkim metodama će se usporediti s globalnom brzinom reakcije kako bi se procijenila značajnost procesa snimljenog spektroskopskim i difrakcijskim metodama. Teorijsko modeliranje pomoću DFT-a (eng. Density functional theory – DFT) će se koristiti za otkrivanje podrijetla mobilnosti kisika u CZ, utjecaj elemenata rijetkih zemalja (eng. Rare-Earth Elements – RE) na mobilnost kisika i utjecaj Rh na svojstva odabranog materijala. Utjecaj Rh i RE na redoks svojstva Ce4+/Ce3+ će se istražiti pomoću time-resolved in situ spektroskopskih i difrakcijskih metoda koje pružaju mogućnost za postizanje globalnog razumijevanja strukturnih promjena povezanih s prisustvom RE bitnih za kapacitet pohrane kisika (eng. Oxygen storage capacity – OSC) i katalitičku aktivnost za redukciju NO i oksidaciju CO.]]></summary_hr><summary_en><![CDATA[Ceria-zirconia (CZ) is widely used in heterogeneous catalysis because of its remarkable property to deliver significant amounts of oxygen to the environment through the reduction of Ce4+ to Ce3+ without loss of its structure. This is exploited for instance in automotive three-way catalysts (TWC) in the control of emissions of gasoline vehicles. In this ambitious cooperative project between Josip Juraj Strossmayer University of Osijek and the University of Novi Sad, we propose to provide an explanation of the mutual effects of the CZ phase, active metal (Rh) from Platinum group, the promoter and rare-earth cations such as La3+, Y3+, Pr3+/4+, also promoters, on the redox properties of the Ce4+/Ce3+. To achieve such demanding goals, the advanced characterization methods will be exploited to follow the reduction and oxidation of Ce and Rh under reaction conditions in representative synthetic TWC feeds. The structural changes followed by the various analytical methods will be compared with the global reaction rate in order to evaluate the relevance of the process captured by spectroscopy/diffraction. A powerful DFT theoretical modelling will be exploited to reveal the origin of the oxygen mobility in CZ, the influence of RE (La, Pr, Y) on the oxygen mobility and the influence of Rh on the properties of a selected material. The effect of Rh and RE on the redox properties of the Ce4+/Ce3+ pair will be exploited using time-resolved in situ spectroscopy/diffraction method providing the possibility to obtain a global understanding of the structural changes associated with the presence of RE and relevant to the OSC and the catalytic activity for NO reduction and CO oxidation.   ]]></summary_en></project><project>
<id>8309</id><title_hr><![CDATA[Biologija citomegalovirusne infekcije u mozgu tijekom razvoja i u latenciji]]></title_hr><title_en><![CDATA[Biology of cytomegalovirus infection in developing brain and latency]]></title_en><user_id>4834</user_id><user_firstLast_name>Ilija Brizić</user_firstLast_name><svouser_id>25710</svouser_id><svouser_firstLast_name>Luka Cicin-Sain</svouser_firstLast_name><proposal_type>PZS</proposal_type><proposal_call>2019-02</proposal_call><code>PZS-2019-02-7879</code><acronim><![CDATA[CMVbrain]]></acronim><duration>01.01.2020 - 31.05.2023</duration><status>Završio</status><financ_value>272.505,14 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Medicine]]></institution_en><team_members_id>4753, 24014, 5204, 20528, 857297, 17801, 861498, </team_members_id><team_members_names><![CDATA[Lea Hiršl, Ester Pernjak Pugel, Paola Kučan Brlić, Ivan Bubić, Andrea Mihalić, Marina Pribanić Matešić, Fran Krstanović, ]]></team_members_names><keywords_hr><![CDATA[citomegalovirus, kongenitalna infekcija, tropizam, stanice mozga, imunološki odgovor, gH/gL, astrociti, mikroglija, neuroni, MCMV]]></keywords_hr><keywords_en><![CDATA[cytomegalovirus, congenital infection, tropism, brain cells, immune response, gH/gL, astrocytes, microglia, neurons, MCMV]]></keywords_en><summary_hr><![CDATA[Prirođena CMV infekcija je glavni uzročnik transplacentarno prenosivih prirođenih infekcija koja može uzrokovati široki spektar strukturnih i funkcionalnih oštećenja i trajne neurološke posljedice. Infekcija mozga tijekom prirođene infekcije CMV-om ima veliki značaj, međutim, stanična mjesta infekcije tijekom akutne faze infekcije i latencije su još uvijek nejasna. In vitro CMV može inficirati do određene razine većinu staničnih vrsta mozga, međutim nije jasno vrijedi li to in vivo, i koja je priroda infekcije (abortivna ili produktivna) je slabo istraženo. Nadalje, nije poznato u kojim stanicama se nalazi latentni CMV i u kojim stanicama CMV reaktivira u mozgu. Mi ćemo se usredotočiti na tri glavne vrste stanice u mozgu: neurone, astrocite i mikrogliju. Kako bi odredili stanične vrste koje su inficirane koristit ćemo reporterski virus MCMV-GFP_Cre koji će nam omogućiti da odredimo u kojim stanicama se nalazi virus tijekom akutne faze infekcije i u latenciji. Nadalje, odredit ćemo u kojim stanicama MCMV reaktivira nakon deplecije T limfocita u mozgu i koje stanice proizvode infektivni virus u mozgu. Također, odredit ćemo transkriptom pojedinačnih stanica u mozgu, kako bi odredili kako infekcija u mozgu mijenja stanice. Kako bi odredili koji gH/gL kompleksi posreduju infekciju stanica u mozgu generirat ćemo nove rekombinantne viruse koji imaju mutacije u genima koji kodiraju za proteine MCK-2 i gO, MCMV proteine koji formiraju gH/gL komplekse. Ova istraživanja će odgovoriti na važna pitanja o infekciji stanica u mozgu, mjestima latencije virusa i izvoru (reaktivirajućeg) virusa u mozgu, kao i koji virusni proteini su važni za infekciju stanica u mozgu. Razumijevanje ovih mehanizama je potrebno kako bi spriječila infekcija i patologija u središnjem živčanom sustavu. Rezultati ovog projekta će pridonijeti boljem razumijevanju patogeneze prirođene CMV infekcije u mozgu, te će otvoriti nove smjerove istraživanje CMV infekcije, kao i terapije.]]></summary_hr><summary_en><![CDATA[Congenital CMV infection is a major cause of trans-placentally transmitted congenital infections and may cause a wide range of structural and functional disabilities and permanent neurological sequelae. Infection of the brain during congenital CMV infection is of great interest, however, the cellular sites of infection during acute and latent infection are still poorly characterized. The majority of brain cell types are fully or partially permissive for CMV in vitro, but it remains unclear which cell types are productively infected in vivo and support viral replication and dissemination within the brain. Furthermore, cells harboring latent CMV and cells reactivating CMV in brain are unknown. We will focus on major cell types in the brain: neurons, astrocytes and microglia. To determine the cellular sites of infection we are going to use a reporter virus (MCMV-GFP_Cre) which will enable us to identify cells harboring virus during acute and latent infection. Furthermore, we will determine which cells reactivate MCMV upon depletion of T cells in brain and cellular source of infectious virus in brain. Finally, we will perform single cell sequencing of uninfected and latently infected cells in the brain, to determine how latent infection remodels the brain cells. To determine which gH/gL complexes mediate infection of brain cells we will generate novel recombinant viruses harboring mutations in MCK-2 and gO, MCMV proteins forming complexes with gH/gL proteins. These studies will answer the longstanding questions regarding the infection, sites of latency and source of (reactivating) virus in brain. In addition, we will determine requirement for viral proteins for infection of brain cells. Understanding these mechanisms is needed to prevent CMV infection and pathology in central nervous system. Results of this project will contribute to better understanding of congenital CMV pathogenesis in brain, and will open new avenues of CMV research and therapy.]]></summary_en></project><project>
<id>8363</id><title_hr><![CDATA[Biomolekule koje vežu metale i zdravstveni poremećaji kod slatkovodnih organizama izloženih industrijskom otpadu]]></title_hr><title_en><![CDATA[Metal-binding biomolecules and health disturbances of freshwater organisms exposed to industrial wastes]]></title_en><user_id>11261</user_id><user_firstLast_name>Zrinka Dragun</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-2636</code><acronim><![CDATA[METABIOM]]></acronim><duration>01.01.2020 - 15.10.2023</duration><status>Završio</status><financ_value>131.493,53 eur</financ_value><scie_area_hr>Prirodne znanosti, Biomedicina i zdravstvo, </scie_area_hr><scie_area_en>Natural sciences, Biomedicine and health sciences, </scie_area_en><scie_field_hr>Interdisciplinarne prirodne znanosti, Kemija, Biologija, Javno zdravstvo i zdravstvena zaštita, Veterinarska medicina, </scie_field_hr><scie_field_en>Interdisciplinary natural sciences, Chemistry, Biology, Public health and health services, Veterinary medicine, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>11251, 5805, 12330, 21287, 26145, 5511, 2691, 12386, 26150, 26154, 25975, 5271, 29281, 865007, 865006, 26083, </team_members_id><team_members_names><![CDATA[Dušica Ivanković, Damir Valić, Vlatka Filipović Marijić, Tatjana Mijošek, Krešimira Trgovčić, Emil  Gjurčević, Krešimir Matanović, Jasna Lajtner, Maria Montes-Bayon, Elisa Blanco-Gonzalez, Zvjezdana Šoštarić Vulić, Snježana Kužir, Fran Barac, Zoran Kiralj, Ivana Karamatić, Tomislav Kralj, ]]></team_members_names><keywords_hr><![CDATA[metali, metalomika, histologija, bioakumulacija, biomarkeri, ribe, školjkaši, rijeka]]></keywords_hr><keywords_en><![CDATA[metals, metallomics, hystology, bioaccumulation, biomarkers, fish, bivalves, river]]></keywords_en><summary_hr><![CDATA[Cilj je ovoga projekta proširiti znanje o posljedicama zagađenja metalima u slatkovodnim ekosustavima primjenom dvaju slatkovodnih bioindikatora, štuke (Esox lucius), kao predstavnika ribljih vrsta, te školjkaša iz porodice Unionidae, iz ekološki značajne hrvatske rijeke Mrežnice, koja je u donjem dijelu svoga toka izložena otpadu nekoliko industrijskih postrojenja. Informacije o onečišćenju riječne vode i sedimenta metalima povezat ćemo s informacijama o bioakumulaciji metala i promjenama koncentracija i aktivnosti nekoliko biomarkera (biomarkera općeg stresa, izloženosti metalima, antioksidativnog kapaciteta i oksidativnih oštećenja) u ribljim jetrima i probavnim žlijezdama školjkaša, kao njihovim glavnim metaboličkim i detoksikacijskim organima, te s informacijama o zdravstvenom stanju riba. Cilj je projekta i rasvjetljavanje sudbine metala u tkivima i stanicama riba i školjkaša, primjenom metalomičkog pristupa. Pomoću triju HPLC tehnika (razdvajanja po veličini, anionske i kationske izmjene) u kombinaciji s HR ICP-MS-om, odredit ćemo raspodjele metala među citosolskim biomolekulama različitih veličina i naboja u jetrima štuke i probavnim žlijezdama školjkaša. Odabrane biomolekule koje vežu metale, koje bi mogle biti korištene kao biomarkeri izloženosti metalima ili biomarkeri učinaka metala, nadalje ćemo okarakterizirati i identificirati pomoću dviju metoda spektrometrije masa (MALDI-TOF-MS i LC-MS/MS). Dobivene informacije vodit će prema boljem razumijevanju funkcija metala, njihove detoksikacije i mehanizama njihove toksičnosti. Značajan aspekt ovoga projekta bit će i procjena ekološkog statusa rijeke Mrežnice te prepoznavanje najugroženijih lokacija i najvažnijih zagađivala, što će pomoći nadležnim tijelima da osiguraju najučinkovitiju zaštitu kakvoće riječne vode, kao i očuvanje akvatičkog života ove rijeke. Projekt će nadalje doprinijeti i obrazovanju mladih znanstvenika, zapošljavanjem novoga doktoranda.]]></summary_hr><summary_en><![CDATA[The aim of this project is to extend the knowledge on the consequences of metal pollution in the freshwater ecosystems using two freshwater bioindicators, fish species northern pike (Esox lucius) and the bivalves from the family Unionidae, from the ecologically important Croatian river Mrežnica, which, in its lower course, is impacted by the waste of several industrial facilities. The information on the river water and sediment contamination with metals will be associated with the information on the metal bioaccumulation and responses of several biomarkers (of general stress, metal exposure, antioxidative capacity and oxidative damage) in the fish liver and bivalve digestive gland, as their main metabolic and detoxification organs, as well as with the information on the fish health status. The project also aims to clarify the fate of metals in fish and bivalve tissues and cells, by application of metallomic approach. By use of three HPLC techniques (size exclusion, anion and cation exchange) combined with HR ICP-MS, metal distribution among cytosolic biomolecules of different sizes and charges in the northern pike liver and bivalve digestive gland will be determined. The metal-binding biomolecules of interest, which could be used as biomarkers of metal exposure or effects, will be further characterized and identified by two mass spectrometry methods (MALDI-TOF-MS and LC-MS/MS). The obtained information will lead to increased understanding of metal functions, detoxification and mechanisms of metal toxicity. Another important aspect of the project will be the assessment of the ecological status of the Mrežnica River and the recognition of the most threatened locations and the most important contaminants, which will help liable authorities to ensure the most effective protection of the water quality and the preservation of the aquatic life of this river. The project will also contribute to education of young scientists, by employing the new PhD student.]]></summary_en></project><project>
<id>8366</id><title_hr><![CDATA[Napredne metode za projektiranje profitabilnog, energetski efikasnog i okolišno prihvatljivog brodograđevnog proizvodnog procesa]]></title_hr><title_en><![CDATA[Advanced Methodologies for Cost Effective, Energy Efficient and Environmentally Friendly Ship Production Process Design]]></title_en><user_id>13308</user_id><user_firstLast_name>Neven Hadžić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2019-04</proposal_call><code>UIP-2019-04-6573</code><acronim><![CDATA[ANTYARD]]></acronim><duration>01.12.2019 - 30.11.2024</duration><status>Završio</status><financ_value>180.383,57 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Brodogradnja, Strojarstvo, </scie_field_hr><scie_field_en>Naval architecture, Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>3244, 855346, 25388, </team_members_id><team_members_names><![CDATA[Tihomir Opetuk, Viktor Ložar, Robert Keser, ]]></team_members_names><keywords_hr><![CDATA[Brodograđevni proizvodni proces, Proizvodno inženjerstvo, Profitabilna proizvodnja, Energetska efikasnost, Okolišna prihvatljivost]]></keywords_hr><keywords_en><![CDATA[Ship production process, Production system engineering, Cost effectiveness, Energy efficiency, Environmental friendliness]]></keywords_en><summary_hr><![CDATA[Značajan utjecaj na gospodarstvo i okoliš može se postići ako se brodograđevni proizvodni proces, kao osnovna djelatnost brodogradilišta, razmotri kao projektabilan, promjenjiv i prilagodljiv. Zbog toga je projekt poput projekta ANTYARD neophodan kako bi se snažno usmjerio razvoj i primjena naprednih metodologija za projektiranje brodograđevnog proizvodnog procesa, uzimajući u obzir profitabilnost, energetsku učinkovitost i okolišnu prihvatljivost. Projektiranje profitabilnog proizvodnog procesa podrazumijeva razvoj i primjenu metodologija planiranja procesa i detaljnog modela troškova proizvodnje kao ključnih zadataka. Prvi pristup zahtijeva razvoj analitičkih i numeričkih postupaka, dok potonji obuhvaća razvoj detaljnog i parametarskog modela proizvodnih troškova. Nadalje, razvit će se model potrošnje energije kako bi se formirala ukupna potražnja i udjeli u energetskoj potrošnji, te kako bi se identificirala energetska uska grla sustava. Razvijeni modeli biti će validirani pomoću podataka iz stvarne brodograđevne proizvodnje. Nadalje, analizirat će se i učinci zagađenja okoliša nastali uslijed provedbe brodograđevnog proizvodnog procesa čime će se omogućiti razvoj racionalne energetske politike te primjena koncepta zelene brodogradnje. Slični pristupi energetskoj potrošnji i istraživanju koncepata zelene brodogradnje su u potpunosti zapostavljeni u suvremenoj brodograđevnoj znanstvenoj zajednici, dok druge proizvodne industrije snažno promiču koncepte zelene proizvodnje. Istraživanje će se provoditi u Laboratoriju za unapređenje brodograđevne tehnologije na Fakultetu strojarstva i brodogradnje Sveučilišta u Zagrebu. Konkurentna, neovisna i propulzivna istraživačka grupa će tijekom istraživanja primjenjivati suvremene znanstvene alate i metodologije.]]></summary_hr><summary_en><![CDATA[A significant impact to economy and environment can be achieved if the ship production process, as the shipyards core business, is considered as designable, changeable and adoptable. This is why we need a project like ANTYARD that is strongly focused to development and application of the advanced methodologies for the ship production process design taking into account production cost effectiveness, energy efficiency and environmental friendliness. Production process design for cost effectiveness implies development and implementation of the process scheduling methodologies and bottom-up production cost models as critical tasks. The former approach requires development of analytical and numerical procedures, while the latter captures development of bottom-up and top-down production cost models. Furthermore, energy consumption model will be developed in order to arrive at the total production energy demand and share as well as to identify energy bottlenecks of the system. The developed models will be verified using shipyards floor data. Based on that, an environmental friendliness and pollution effects of the ship production process will be analysed enabling carbon footprint evaluation, rational energy and production policy development and implementation of the green ship production concepts. Similar energy demand-supply approaches and research on green ship production concepts are completely absent in the present literature body, while other manufacturing industries strongly promote green production concepts. The research will be implemented at the Laboratory for the improvement of shipbuilding technology at the Faculty of Mechanical Engineering and Naval Architecture, University of Zagreb. State of the art scientific tools and methodologies will be applied by a competitive, independent and propulsive project team.]]></summary_en></project><project>
<id>8368</id><title_hr><![CDATA[Istraživanje starije hrvatskoglagoljske zborničke baštine]]></title_hr><title_en><![CDATA[Research of the Old Croatian Glagolitic Miscellany Heritage]]></title_en><user_id>25636</user_id><user_firstLast_name>Vesna  Stipčević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-5942</code><acronim><![CDATA[CROGLAGPAR73]]></acronim><duration>01.02.2020 - 31.01.2024</duration><status>Završio</status><financ_value>53.819,10 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filologija, </scie_field_hr><scie_field_en>Philology, </scie_field_en><institution_hr><![CDATA[Staroslavenski institut]]></institution_hr><institution_en><![CDATA[Old Church Slavonic Institute in Zagreb]]></institution_en><team_members_id>25757, 25724, 1236, 25886, </team_members_id><team_members_names><![CDATA[Marinka Šimić, Kristijan Kuhar, Tanja Kuštović, Petra Stankovska, ]]></team_members_names><keywords_hr><![CDATA[hrvatskoglagoljska baština, hrvatskoglagoljski srednjovjekovni zbornici, hrvatskoglagoljska književnost, latinička transliteracija, filologija ]]></keywords_hr><keywords_en><![CDATA[Croatian Glagolitic Heritage, Croatian Glagolitic Medieval Miscellanies, Croatian Glagolitic literature, Latin transliteration, philology]]></keywords_en><summary_hr><![CDATA[U središtu istraživanja projektnoga prijedloga je starija hrvatskoglagoljska zbornička baština, osobito najstariji cjelovito sačuvani hrvatskoglagoljski Pariški (Borislavićev) zbornik Slave 73 iz 1375. godine. Dosadašnja istraživanja ovoga izuzetno vrijednog i opsežnog (296 pergmentnih folija) rukopisa pokazala su da bi bilo potrebno ne samo nastaviti nego i intenzivirati istraživanje zborničkoga sadržaja te proširiti proučavanje i na zborničke dijelove koji do sada nisu bili obuhvaćeni istraživanjima. Namjera je projektnoga prijedloga da se multidisciplinarnim filološkim istraživanjima, književnopovijesnim, tekstološkim, jezičnim analizama te povijesnoliturgijskim istraživanjima detaljno opiše Pariški zbornik Slave 73, istraže njegove društvene, liturgijske, književne i estetske funkcije te da se utvrdi odnos zbornika prema hrvatskoglagoljskoj liturgijskoj tradiciji (brevijarima, misalima, ritualima) i neliturgijskoj baštini (drugim zbornicima). U daljnjem proučavanju osobita bi pažnja bila posvećena činjenici da je Borislavićev zbornik rijedak primjer glagoljaške knjige namijenjene ženskoj publici, jer je u kolofonu zabilježeno da je napisan za redovnice šibenskog samostana svetog Julijana. Istraživački ciljevi projekta su: (1) pripremiti latinično transliterirano izdanje glagoljskoga Pariškoga zbornika Slave 73; (2) multidisciplinarno filološko i povijesnoliturgijsko istraživanje najstarijega cjelovito sačuvanoga glagoljskoga zbornika; (3) istražiti Pariški zbornik Slave 73 u kontekstu drugih hrvatskoglagoljskih spomenika i na taj način uspostaviti prototip za daljnja istraživanja. Latiničnim izdanjem Pariškoga zbornika Slave 73 hrvatska i međunarodna, znanstvena i kulturna zajednica, dobila bi uvid u sadržaj i značenje vrijednoga glagoljskog rukopisa. Utvrđivanje izvora i predložaka na temelju kojih je ovaj kodeks oblikovan, zasigurno će proširiti spoznaje o tragovima filoloških, književnih, liturgijskih i kulturnih utjecaja u srednjovjekovnoj Hrvatskoj. ]]></summary_hr><summary_en><![CDATA[The research topic of the project proposal is the older Croatian Glagolitic miscellany heritage, particularly The Paris Miscellany (Slave 73) by Grgur Borislavić, the oldest completely preserved Croatian Glagolitic miscellany dating from 1375. Previous research carried out on this extremely valuable and comprehensive manuscript with 296 parchment folios shows that it is necessary not only to continue but also to intensify research activities regarding the miscellany and to further expand them to cover those parts of the miscellany that have not been investigated so far. The intention of the project proposal is to apply multidisciplinary philological research methods, literary-historical, textological and linguistic analyses as well as liturgical research to describe The Paris Miscellany (Slave 73) in detail, study its social, liturgical, literary and aesthetic functions and establish a relationship between the miscellany and the Croatian Glagolitic liturgical tradition on the one hand and the non-liturgical heritage on the other. With further study, special attention would be given to the fact that The Paris Miscellany is a rare specimen of Glagolitic literature aimed at female readers or listeners: the colophon notes that the miscellany was written for the nuns of St Julian’s Convent in Šibenik. The objectives of this research are the following: (1) to prepare a Latin transliteration of miscellany Slave 73; (2) to conduct a multidisciplinary study covering philological and liturgical aspects of the oldest completely preserved Glagolitic miscellany; (3) to study miscellany Slave 73 in the context of other Croatian Glagolitic monuments and thus establish a prototype for further study. With miscellany Slave 73 prepared in this way, both the Croatian and the international scientific and cultural communities would gain an essential insight into the content and importance of this valuable Glagolitic manuscript. ]]></summary_en></project><project>
<id>8369</id><title_hr><![CDATA[Racionalan dizajn prirodnih eutektičkih otapala za pripremu i formulaciju kiralnih lijekova  ]]></title_hr><title_en><![CDATA[Rational design of natural deep eutectic solvents for chiral drugs preparation and formulation]]></title_en><user_id>3228</user_id><user_firstLast_name>Ivana Radojčić Redovniković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-7712</code><acronim><![CDATA[NADESChiralDrug]]></acronim><duration>01.01.2020 - 30.06.2024</duration><status>Završio</status><financ_value>169.354,17 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Biotehnologija, Interdisciplinarne biotehničke znanosti, </scie_field_hr><scie_field_en>Biotechnology, Interdisciplinary biotechnical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Food Technology and Biotechnology]]></institution_en><team_members_id>17606, 5279, 2509, 5443, 6126, 2512, 21346, 19402, 6112, 26375, 26468, 857311, 865178, </team_members_id><team_members_names><![CDATA[Giancarlo  Cravotto, Višnja Gaurina Srček, Senka Djaković, Kristina  Radošević, Marina Cvjetko Bubalo, Jasmina Lapić, Manuela  Panić, Željko  Jakopović, Marko Rogosic, Thanos Andreou, Maria Andrielou, Mia Radović, Martina Bagović, ]]></team_members_names><keywords_hr><![CDATA[biokataliza, kiralni sintoni, NADES, zelena otapala, THEDES]]></keywords_hr><keywords_en><![CDATA[biocatalysis, chiral synthon, NADES, green solvents , THEDES]]></keywords_en><summary_hr><![CDATA[Moderna kemijska i farmaceutska industrija zahtjeva visoki stupanj enantiomerne čistoće biološki aktivnih kiralnih spojeva stoga se razvijaju različite metode za proizvodnju i formulaciju kiralnih lijekova. Uvidom u suvremenu literaturu očituje se sve veći interes za nove i ekološki prihvatljive pristupe u pripravi i formulaciji kiralnih lijekova: primjena prirodnih eutektičkih otapala (NADES) kao medija za njihovu pripravu ili kao pomoćnog sredstva za isporuku kiralnog lijeka kroz sintezu terapeutskih eutektičkih otapala (THEDES). Međutim, unatoč obećavajućim rezultatima primjene ovih otapala, dosadašnja potraga za idealnim NADES za određeni reakcijski sustav vođena je empirijskim pristupom pokušaja i pogrešaka, pri čemu je sistematsko istraživanje odnosa struktura-aktivnoststruktura-aktivnost NADES, kao okosnice racionalnog dizajna ovih otapala za specifične namjene, još uvijek u povojima. To je izravna posljedica nedostatka temeljnih znanja o ovim otpalima, a što onemogućava potpuno razumijevanje njihove mehanističke uloge u raznim biotehnološkim procesima. Stoga, prikupljanje podataka o osnovnim svojstvima NADES te razvoj matematičkih metoda kao alata za dizajniranje otapala s optimalnim svojstvima predstavlja imperativ za njihovu industrijsku primjenu. Na temelju navedenog, glavni cilj predloženog multidisciplinarnog Projekta jest stjecanje znanja o NADES te istraživanje prednosti njihove primjene u zelenom pristupu priprave i formulacije kiralnih lijekova. Kako bi ostvarili zadane ciljeve projekta, definirani su sljedeći specifični ciljevi: (1) racionalni dizajn NADES za pripravu i formulaciju kiralnog lijeka (2) implementacija NADES u enzimski kataliziranoj pripravi intermedijera kiralnog lijeka (3) razvoj THEDES kao poboljšane formulacije kiralnog lijeka. Ovo multidisciplinarno istraživanje koje uključuje organske kemičare, biotehnologe i farmaceute bilo bi dokaz koncepta NADES kao otapala/pomoćne tvari u pripravi i formulaciji enantiomerno čistih lijekova.]]></summary_hr><summary_en><![CDATA[Nowadays, single-enantiomer drugs have become the standard in pharmaceutical companies when working with compounds featuring stereogenic centers, mobilizing chemical and biotechnological industry to develop versatile methods for production and formulation of biologically active chiral compounds of high enantiomeric purity. Overview of current literature on chiral drug production and formulation reveals exciting, new and green approach: the use of natural deep eutectic solvents (NADES) as medium for biotechnological preparation of chiral biologically active compounds and as auxiliaries in development of chiral drug delivery system through designing therapeutic deep eutectic solvents (TEHDES). However, this exciting research field still faces several great challenges. Namely, approaches used so far for screening ideal NADES have been governed by time consuming empirical methods, while systematic investigation in NADES structure-activity relationship, as a backbone for rational design of these solvents, is still lacking. Extension of fundamental research on NADES solvent properties, as well as development of mathematical models as tools for designing ideal NADES for specific purpose becomes an imperative for industrial use of NADES. Based on the stated above the aim of proposed Project is to is to demonstrate the advantages of using NADES as green approach in the biotechnological preparation and formulation of chiral drugs. To achieve Project goals, specific objectives of the Project are, therefore, the following: (1) rational design of NADES for chiral drug preparation and formulation (2) implementation of NADES in enyzme-catalyzed preparation of chiral drug intermediates (3) development of THEDES as improved formulation of chiral drug. This multidisciplinary research which includes chemists, biotechnologists and pharmacist would be our proof-of-concept of the NADES promising use as solvents/auxiliaries in enantiopure drug preparation and formulation. ]]></summary_en></project><project>
<id>8370</id><title_hr><![CDATA[Povezanost genskih polimorfizama s temporomandibularnim poremećajima]]></title_hr><title_en><![CDATA[Genetic polymorphisms and their association with temporomandibular disorders]]></title_en><user_id>612</user_id><user_firstLast_name>Iva Alajbeg</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-6211</code><acronim><![CDATA[GenPolTMD]]></acronim><duration>01.02.2020 - 31.01.2024</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Dentalna medicina, Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Dental medicine, Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Stomatološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Dentistry]]></institution_en><team_members_id>21042, 25647, 3378, 5987, 23312, 24296, 4284, 26707, 858422, 865464, 865465, </team_members_id><team_members_names><![CDATA[Ema Vrbanović, Zlatko Dembic, Lea Vuletić, Ivan Alajbeg, Senka Meštrović, Ivana Lapić, Dijana Zadravec, Davor Illeš, Marko Zlendić, Ivan Orabović, Klara Naka, ]]></team_members_names><keywords_hr><![CDATA[temporomandibularni poremećaji, orofacijalna bol, polimorfizam jednog nukleotida, genetika boli, genetski čimbenici rizika, opiorfin]]></keywords_hr><keywords_en><![CDATA[temporomandibular disorders, orofacial pain, single nucleotide polymorphisms,  pain genetics, genetic risk factors, opiorphin]]></keywords_en><summary_hr><![CDATA[Temporomandibularni poremećaji (TMP) najčešći su orofacijalni bolni poremećaji nedentalnog porijekla, s prevalencijom u populaciji 6,1-10,2% i incidencijom od 3,9%. Patološki supstrat uglavnom izostaje, a uzrok često ostaje nepoznat. Kako se za druga bolna stanja nejasnog porijekla (npr. fibromialgija) predlažu genski čimbenici, cilj je našeg istraživanja ispitati predstavlja li genetska predispozicija rizik za nastanak TMP-a. Stoga ćemo određivati ciljne polimorfizme u odabranim genima u osoba s TMP-om (DK/TMP upitnik) i kontrolnih ispitanika te istražiti postoji li povezanost polimorfizama i odgovora na liječenje. Hipoteze: (I) pojavnost specifičnih genskih polimorfizama (usporedba pacijenata i kontrole) primarno ovisi o prisustvu/odsustvu TMP-a, a moguće i o izvoru i intenzitetu boli, prisustvu promjena na kosti, prisutnim psihološkim značajkama i prethodnoj ortodontskoj terapiji te (II) odgovor na liječenje razlikovat će se ovisno o prisutnim polimorfizmima. Usporedno s anamnestičkom i kliničkom obradom, te terapijom okluzijskom udlagom, provest će se analiza genomske DNA iz obriska bukalne sluznice. Izdvojena DNA koristit će se za određivanje 19 polimorfizama odabranih gena metodom Real-Time PCR. Paralelno, provest će se analiza biljega oksidacijskog stresa i opiorfina iz sline, čija je povezanost s TMP-om dokazana našim prethodnim istraživanjima. Ovaj put, njihova će se koncentracija usporediti s polimorfizmima u genima promotorima odgovornima za njihovu sintezu. Očekujemo da će se određene skupine polimorfizama pokazati kao faktor rizika za TMP-a. Inovativnost u smislu utvrđivanja genetske sklonosti za razvoj TMP-a ima potencijal za komercijalizaciju genetičkog testa kojim bi se mogao procijeniti rizik za razvoj bolesti i/ili odgovor na liječenje, čime bi se mogla indicirati rana intervencija i aktivno izbjegavanje okolišnih čimbenika rizika.]]></summary_hr><summary_en><![CDATA[Temporomandibular disorders (TMD) are the most common orofacial pain disorders of non-dental origin with the prevalence of 6.1–10.2%, and incidence of 3.9%. Observable pathology is mostly absent, and the etiology often remains unknown. Since some other painful conditions of unknown origin (eg. fibromyalgia), also imply genetic factors, the aim of the study is to investigate genetic predisposition in relation to the risk for TMD onset. This will be achieved through analysis of polymorphisms in the selected genes in TMD patients (DC/TMD) and matched control subjects. The possibility of involvement of specific polymorphisms in modulation of therapy response will also be investigated. The hypotheses: (I) the Single Nucleotide Polymorphism (SNPs) clustering will be dependent on presence or absence of TMD (comparison of patients with control subjects), and will possibly depend on source of pain, pain intensity, presence of bone changes, psychological features and previous orthodontic therapy, and (II) SNPs will influence the treatment response. Along with anamnestic and clinical examination and occlusal splint therapy, genomic DNA will be analyzed from the buccal swabs. Isolated DNA will be used for the determination of 19 polymorphisms of selected genes using Real-Time PCR method. The analysis of salivary oxidative stress markers and opiorphin will be also performed, as their relationship with TMD has been shown previously. This time, their concentration will be associated with polymorphisms in the promoters of genes responsible for their synthesis. We expect to show that particular gene profile or group of SNPs represent a risk factor for TMD development. Innovative approach of the concept of determining the genetic predisposition for TMD has the potential for development of commercial genetic test with potential for risk estimation in relation to TMD onset. This could enable early interventions and active avoidance of environmental risk factors.]]></summary_en></project><project>
<id>8371</id><title_hr><![CDATA[Geni spužvi povezani s nastankom raka]]></title_hr><title_en><![CDATA[Cancer-related genes in sponges]]></title_en><user_id>1193</user_id><user_firstLast_name>Helena Ćetković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-5382</code><acronim><![CDATA[CanSponGE]]></acronim><duration>25.02.2020 - 24.07.2024</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>1228, 1207, 1187, 25324, 1107, 1221, 856260, 17865, 1426, </team_members_id><team_members_names><![CDATA[Matija Harcet, Helena Bilandžija, Kristian Vlahoviček, Silvestar Beljan, Maja Herak Bosnar, Andreja Mikoč, Antea Talajić, Kristina Dominko, Nikolina Škrobot Vidaček, ]]></team_members_names><keywords_hr><![CDATA[evolucija, Metazoa, Porifera, spužve, tumori, evolucija raka, geni povezani s nastankom raka]]></keywords_hr><keywords_en><![CDATA[evolution, basal metazoans, Porifera, sponges, tumors, cancer evolution, cancer-related genes]]></keywords_en><summary_hr><![CDATA[Proučavanje ljudskih bolesti korištenjem životinja kao eksperimentalnih modela ključno je za razumijevanje uzroka, biologije i prevencije bolesti. Malo se zna o genima povezanim s nastankom raka kod beskralježnjaka, osobito kod najjednostavnijih životinja - &#39;&#39;bazalnih&#39;&#39; Metazoa. Posljednjih nekoliko godina raste zanimanje za proučavanje evolucije gena povezanih s nastankom raka budući da je široki repertoar tih gena već prisutan u genomima morfološki jednostavnih životinja. Većina ovih gena pojavila se tijekom dva glavna evolucijska događaja – s pojavom eukariota i pri prelasku u višestaničnost, tj. nastanku životinja. Stoga proučavanje gena povezanih s nastankom raka kod ljudi na nivou jednostavnijih organizama, kao što su spužve, jedna od najstarijih skupina životinja, pruža bolji uvid u njihovu evoluciju i osnovnu fiziološku funkciju. Spužve su morfološki najjednostavnije životinje, bez bilateralne simetrije, tkiva i organa, koje su se vrlo malo mijenjale tijekom evolucije. Usprkos tome, posjeduju kompleksan genom u kojem većina gena pokazuje visoku sačuvanost s homolozima kod kralježnjaka te stoga daju najbolji uvid u svojstva genoma i proteoma pretka svih Metazoa. Cilj projekta je identificirati i okarakterizirati spužvine proteine čiji su homolozi kod čovjeka povezani s nastankom raka kako bi dobili što bolji uvid u evoluciju raka. Ovakav inovativni pristup na relativno jednostavnom modelu pružit će nam uvid u osnovne fiziološke funkcije gena povezanih s nastankom raka, prije njihove diverzifikacije i specijalizacije kroz evoluciju životinja. Naše istraživanje gena spužvi povezanih s nastankom raka pomoći će u razjašnjavanju složenijih interakcija njihovih homologa kod ljudi i time objasniti moguće razloge njihovog onkogenog potencijala. Zbog važnog evolucijskog položaja spužvi na samoj bazi filogenetskog stabla životinja, svaki novi uvid u svojstva njihovih homologa povezanih s rakom poboljšat će naše razumijevanje ove bolesti kod ljudi.]]></summary_hr><summary_en><![CDATA[The use of animals as experimental models for human diseases is imperative for understanding the causes, biology, and prevention of diseases. To date, little is known about the functions of cancer-related genes in invertebrates, especially in non-bilaterian Metazoa. In the last few years, the interest in genes associated with cancer from an evolutionary perspective is increasing, since it has been shown that many of them were already present in simple non-bilaterian animals. The majority of these genes appeared in two major evolutionary transitions - the emergence of eukaryotes and the transition to multicellularity in the animal lineage. Therefore, studying cancer-related genes in organisms at the base of Metazoa, such as sponges, can help unravel the original function as well as the evolution of those genes. Sponges are morphologically simple animals, with no tissues and organs, which have changed little during evolution. Despite that, sponges possess complex genomes with many genes highly similar to their vertebrate homologs. Therefore, they provide an invaluable insight into the metazoan last common ancestors’ genome and proteome features. The aim of the proposed project is to identify and characterize sponge homologs of human cancer-related genes and thus gain a clearer picture of the evolution of cancer. Such an innovative approach using a simple model system will provide insights into the original ancestral physiological functions of cancer-related genes before their diversification and specialization in &#39;&#39;higher&#39;&#39; animals. Our understanding of the basic physiological properties of cancer-related genes in simple animals will aid in unravelling complex interactions of their human homologs and thus elucidate possible causes of their oncogenic potential. Due to the &#39;&#39;basal&#39;&#39; phylogenetic position of sponges within animals, new insights in the properties of their cancer-related homologs will substantially improve our understanding of this disease.]]></summary_en></project><project>
<id>8376</id><title_hr><![CDATA[Metal-organski molekulski materijali kao potencijalni feroelektrici]]></title_hr><title_en><![CDATA[Metal-organic molecule-based materials as potential ferroelectrics]]></title_en><user_id>12971</user_id><user_firstLast_name>Lidija Androš Dubraja</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2019-04</proposal_call><code>UIP-2019-04-7433</code><acronim><![CDATA[MOLFERR]]></acronim><duration>11.05.2020 - 10.05.2025</duration><status>Završio</status><financ_value>243.546,35 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, Interdisciplinarne prirodne znanosti, </scie_field_hr><scie_field_en>Chemistry, Interdisciplinary natural sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>623, 864954, 866636, </team_members_id><team_members_names><![CDATA[Andreas Puškarić, Marko Dunatov, Mia Mesić, ]]></team_members_names><keywords_hr><![CDATA[molekulski materijali, metal-organski hibridni spojevi, sinteza, kristalna struktura, fazne transformacije, feroelektrici, metal-organski tanki film]]></keywords_hr><keywords_en><![CDATA[molecule-based materials, metal-organic hybrid compounds, synthesis, crystal structure, phase transition, ferroelectrics, metal-organic thin film]]></keywords_en><summary_hr><![CDATA[Potraga za novim multifunkcionalnim i ekološki prihvatljivim materijalima nameće nove izazove u sintezi i izvedbi suvremenih tehnoloških uređaja. Molekulski spojevi kao nova klasa materijala koji su se nedavno pojavili na feroelektričnoj sceni nude neka nova i uzbudljiva svojstva koja bi mogla omogućiti tehnološki napredak elektroničkih uređaja. Cilj ovog projekta je istražiti nekoliko klasa metal-organskih spojeva s potencijalnim feroelektričnim svojstvima. Dizajn ovih materijala bit će usmjeren na spojeve sa specifičnim molekulskim fragmentima koji su pokazali da ili mogu imati trajni dipolni moment ili mogu inducirati strukturne transformacije koje mogu dovesti do njegove pojave. Spojevi će biti pripremljeni različitim laboratorijskim tehnikama, literaturno poznatim ili originalnim postupcima sinteze. Da bi se postigla optimalna feroelektrična svojstva, materijal bi idealno trebao biti slobodan od nečistoća i defekata u strukturi i pokazati visoku kristalnost, što podrazumijeva detaljnu strukturnu analizu. Uvjerljiva strategija za potvrdu paraelektrično-feroelektričnog faznog prijelaza, prije feroelektričnog ispitivanja, je odrediti termički inducirane promjene mjerenjem diferencijalne skenirajuće kalorimetrije i dielektričnih karakteristika. Naposljetku, feroelektrično ponašanje će se analizirati mjerenjem polarizacije u ovisnosti o električnom polju, i broju ciklusa. Važan aspekt u različitim primjenama elektroničkih uređaja je proizvodnja visokokvalitetnih tankih filmova. Kako bi se približili potencijalnoj primjeni, proučavani metal-organski spojevi bit će priređeni kao tanki filmovi, koristeći jednostavne kemijske metode depozicije, kao što su spin- i dip-coating. Kada se postigne optimalna kvaliteta tankog filma, metal-organski spojevi će biti integrirani u uređaje za feroelektrična ispitivanja. Ovaj projekt pruža uzbudljivu priliku za istraživanje odnosa između strukture, morfologije i feroelektričnih svojstava metal-organskih spojeva.]]></summary_hr><summary_en><![CDATA[The quest for novel multifunctional and environmentally friendly materials imposes new challenges in the synthesis and performance of modern technological devices. Molecule-based compounds as a new class of materials that recently appeared on the ferroelectrics scene offer some new and exciting features that could allow for technological improvement of electronic devices. The aim of this project is to explore several classes of metal-organic compounds with potential ferroelectric properties. Design of these materials will be set on compounds with specific molecular fragments that have shown to either have the ability to possess a permanent dipole moment or to undergo or induce structural transformations that may lead to its occurrence. Compounds will be prepared by different laboratory techniques through the literature known or original synthetic procedures. To achieve optimum ferroelectric properties, material should ideally be free of impurities and defects in structure and exhibit high overall crystallinity, so detailed structural analysis will be required. A convincing strategy to confirm the paraelectric-ferroelectric phase transition, prior to ferroelectric testing, is to determine thermally induced changes measuring differential scanning calorimetry and dielectric characteristics. Finally, ferroelectric behaviour will be analysed by polarization switching and fatigue experiments. Important aspect in various electronic device applications is to produce high-quality thin films. In order to come closer towards potential applications, studied metal-organic compounds will be downsized to thin films, using simple chemical methods of depositions, such as spin- and dip-coating. Once the optimal thin film quality is achieved metal-organic compounds will be integrated into devices for ferroelectric testing. This project provides an exciting opportunity to investigate the relationship among structure, morphology, and ferroelectric properties of metal-organic compounds.]]></summary_en></project><project>
<id>8379</id><title_hr><![CDATA[Dinamika Aktivnih i Rotirajućih KONstrukcija]]></title_hr><title_en><![CDATA[Dynamics of Active and Rotating Structures]]></title_en><user_id>25884</user_id><user_firstLast_name>Neven Alujević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-5402</code><acronim><![CDATA[DARS]]></acronim><duration>01.02.2020 - 31.01.2024</duration><status>Završio</status><financ_value>190.511,78 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Temeljne tehničke znanosti, Brodogradnja, Elektrotehnika, Strojarstvo, Zrakoplovstvo, raketna i svemirska tehnika, </scie_field_hr><scie_field_en>Basic engineering sciences, Naval architecture, Electrical engineering, Mechnical engineering, Aerospace, missile and space engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>5584, 12344, 7741, 25931, 864953, 865360, </team_members_id><team_members_names><![CDATA[Ivan Ćatipović, Hinko Wolf, Ivo Senjanovic, Damjan Čakmak, Marin Jalšić, Srećko Arandia-Krešić, ]]></team_members_names><keywords_hr><![CDATA[Vibracije, Akustika, Vibroakustika, Automatska regulacija vibracija, Vibracije rotirajućih konstrukcija]]></keywords_hr><keywords_en><![CDATA[Vibration, Acoustics, Vibroacoustics, Active vibration control, Vibration of rotating structures ]]></keywords_en><summary_hr><![CDATA[U posljednjih dvadesetak godina vibroakustička kvaliteta tehničkih proizvoda postaje iznimno važna za kompetitivnost gospodarstava zemalja EU kao i za blagostanje njihovih građana. Primjerice, zagađenje bukom u prometu drugi je po redu uzrok povećanja smrtnosti građana EU. Njegovanje relevantnih inženjerskih disciplina i ciljana izobrazba novih stručnjaka u tom području jednako je važna i za razvoj hrvatskog gospodarstva i društva.Projektom DARS obrađuju se dvije znanstveno i tehnologijski zahtjevne istraživačke teme u području buke i vibracija.Prva tema je automatska regulacija buke i vibracija, s posebnim fokusom na razvoj nove klase aktivnih metamaterijala kroz koje se transmisija zvuka može suzbijati selektivno. Trenutno gorući istraživački problem u ovom području je kako poremetiti princip recipročnosti koji inače općenito vrijedi za linearne akustičke medije i linearno-elastična tijela. Projektom DARS razvit će se i provjeriti aktivna ćelija metamaterijala kako bi se demonstrirala mogućnost narušavanja principa recipročnosti transmisije zvuka kroz meta-materijalnu prepreku. Druga tema obuhvaća vibracije rotirajućih deformabilnih konstrukcija kao što su osovinski vodovi brodova ili automobilski pneumatici. Kod takvih konstrukcija postoji potreba za boljim razumijevanjem i kvalitetnijim opisom fizikalnih mehanizama koji uzrokuju pojavu rotirajućih formi vibriranja i bifurkacija prirodnih frekvencija. Kroz provedbu projekta DARS razvit će se i provjeriti fizikalno jasni modeli za analizu vibracijskog ponašanja takvih konstrukcija.Dvije istraživačke teme osnova su za dvije doktorske disertacije pa će se dvoje mladih istraživača profilirati kroz stjecanje novih znanja uz upotrebu najmodernijih istraživačkih metoda i opreme. Mladi istraživači će se integrirati u aktivnu i produktivnu istraživačku grupu iskusnu u području buke i vibracija stječući nove vještine i povećavajući svoju zapošljivost. Za potrebe provedbe projekta opremit će se vibroakustički laboratorij.]]></summary_hr><summary_en><![CDATA[In the last two decades noise and vibration quality of engineering products has become increasingly important for the competitiveness of industries of the EU countries and for the well-being of their citizens. For example, transportation noise is the second most deadly environmental pollutant in the EU. Nourishing the relevant engineering disciplines and a targeted education of new experts in the area is equally relevant for the development of Croatian economy and society. DARS project deals with two scientifically and technologically challenging research topics in the area of sound and vibration. The first topic is the active control of sound and vibration, in particular the development of a new class of active metamaterials that are able to selectively reduce sound transmission through them. A currently hot problem here is how to disrupt the well-known reciprocity principle in acoustic and structural media. Within the scope of DARS project an active metamaterial cell will be developed and validated in order to demonstrate the feasibility of non-reciprocal sound transmission through it.The second topic is the dynamics of rotating flexible structures, such as ship power transmission lines or automotive tyres. In such structures, there is a need to fully understand and describe the physical mechanisms of the generation of rotating modes and the bifurcation of natural frequencies with rotation speed. Within the scope of DARS project, physically transparent models that capture the relevant phenomena will be developed and validated.The two research trajectories will enable two PhD students to benefit from training through research using the most recent methods and equipment, boosting their expertise and employability. The young researchers will be immersed into an active and productive research group of scientists experienced in the area of sound and vibration. A laboratory for experimental vibroacoustics necessary for the project execution will be judiciously equipped.]]></summary_en></project><project>
<id>8383</id><title_hr><![CDATA[Endocitoza adenovirusa i urođeni imunosni odgovor]]></title_hr><title_en><![CDATA[Adenovirus endocytosis and innate immune response]]></title_en><user_id>12819</user_id><user_firstLast_name>Dragomira Majhen</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-6048</code><acronim><![CDATA[AdenoIN]]></acronim><duration>15.01.2020 - 14.07.2024</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>21250, 5654, 25895, 856291, 25278, </team_members_id><team_members_names><![CDATA[Davor Nestić, Lidija Cvetko Krajinović, Alan  Parker, Isabela Pehar, Lucija Lulić, ]]></team_members_names><keywords_hr><![CDATA[adenovirus tipa 26, vektorsko cjepivo, integrin, endocitoza, urođeni imunitet]]></keywords_hr><keywords_en><![CDATA[adenovirus type 26, vector vaccine, integrin, endocytosis, innate immunity]]></keywords_en><summary_hr><![CDATA[Vektorska cjepiva na bazi adenovirusa tipa 26 (HAdV26) istražuju se u 28 kliničkih ispitivanja, od kojih je nekoliko u fazi III. Dok je in vivo imunogenost HAdV26 prilično dobro opisana, osnovna biologija ovog virusa je još uvijek nedovoljno shvaćena. Nedavno smo pokazali da je avß3 integrin potreban za uspješnu infekciju epitelnih stanica s HAdV26, no nedostaju istraživanja vezana uz urođeni imunosni odgovor potaknut infekcijom epitelnih stanica s HAdV26 te endocitozu ovog virusa. Na temelju naših preliminarnih podataka pretpostavljamo da bi izmijenjena endocitoza HAdV26 zbog vezanja avß3 integrina ili smanjenog klatrina mogla potaknuti različit imunosni odgovora domaćina, te tako utjecati na uspješnost vektora baziranog na HAdV26. Cilj AdenoIN-a je istražiti urođeni imunosni odgovor potaknut infekcijom epitelnih stanica s HAdV26 u kontekstu upotrebe avß3 integrina kao receptora i/ili izmijenjene endocitoze virusa zbog smanjene količine klatrina. Stoga ćemo u stanicama s povećanom ekspresijom avß3 integrina i/ili smanjenom količinom klatrina nakon infekcije s HAdV26 koristeći metode western blot, ELISA, konfokalna mikroskopija i PCR čip: i) proučavati endocitozu fluorescentno obilježenog HAdV26, ii) profilirati gene povezane s urođenim imunitetom i inflamasomom, iii) analizirati identificirane proteine od interesa. Ukupni rezultat AdenoIN-a bit će sveobuhvatna analiza avß3 integrinom i klatrinom posredovane endocitoze HAdV26 i time potaknutog urođenog imuniteta u epitelnim stanicama. Dobiveni podaci omogućit će daljnja poboljšanja vektora za prijenos gena i cijepljenje temeljenih na HAdV26, te će tako privući interes ne samo akademskih kolega koji istražuju isto područje, nego i dionika iz industrije. Znanje i iskustvo stečeno u okviru AdenoIN-a, kao i novozaposleni doktorand i poslijedoktorand, omogućit će jačanje i daljnji razvoj nedavno uspostavljene istraživačke grupe za proučavanje adenovirusnih vektora koju na IRB-u vodi prijaviteljica ovog projekta.]]></summary_hr><summary_en><![CDATA[Vaccine vectors based on low seroprevalent adenovirus type 26 (HAdV26) are listed as intervention in 28 clinical trials, among which several in phase III. While HAdV26 immunogenicity in vivo is rather well described, basic biology of this virus is still insufficiently understood. Recently we reported avß3 integrin as a receptor required for HAdV26 successful infection of epithelial cells, however studies regarding HAdV26 endocytosis and innate immunity induced by HAdV26 infection of epithelial cells are missing. Based on our preliminary data we hypothesize that altered HAdV26 endocytosis due to binding avß3 integrin or downregulating clathrin, could lead to induction of different host innate immune response, hence influence performance of HAdV26-based vector. Therefore, the goal of AdenoIN is to address clear gap in understanding the innate immune response induced by HAdV26 infection of epithelial cells in the context of using avß3 integrin as a receptor and/or altered virus endocytosis due to lack of clathrin. Thus, in mock and HAdV26 infected cells with increased expression of avß3 integrin and/or downregulated or inhibited clathrin we will i) study endocytosis of fluorescently labeled HAdV26 by confocal microscopy, ii) profile innate immunity and inflammasome related genes by PCR array, iii) analyze identified proteins of interest by western blot, ELISA, confocal microscopy. Final output of AdenoIN will be comprehensive analysis of avß3 integrin and clathrin mediated HAdV26 endocytosis and subsequent innate immune signaling in epithelial cells. Those data will be valuable for further improvement of HAdV26-based vectors, hence will attract interest not only of academic peers, but also stakeholders from the industry. Knowledge acquired within AdenoIN as well as newly employed doctoral and postdoctoral students will enable strengthening and further development of recently established research group for studying adenovirus vectors led at RBI by PI of this project. ]]></summary_en></project><project>
<id>8387</id><title_hr><![CDATA[Prijenos tvari kroz biološke membrane potpomognut proteinima]]></title_hr><title_en><![CDATA[Protein Assisted Translocation of Matter across Biological Membranes]]></title_en><user_id>440</user_id><user_firstLast_name>Mario Vazdar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-3804</code><acronim><![CDATA[ProtBioMemb]]></acronim><duration>01.12.2019 - 30.11.2023</duration><status>Prekinut</status><financ_value>129.404,74 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, Fizika, Biologija, </scie_field_hr><scie_field_en>Chemistry, Physics, Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>26152, 5002, 373, 21289, 3618, 19550, </team_members_id><team_members_names><![CDATA[Dejan Milenković, Danijela Bakarić, Katarina Vazdar, Sanja Škulj, Zlatko Brkljača, Pohl Elena, ]]></team_members_names><keywords_hr><![CDATA[prijenos tvari kroz staničnu membranu, molekulska dinamika, izračuni slobodne energije, fluorescentno ispitivanje, mitohondrijski nosači]]></keywords_hr><keywords_en><![CDATA[cell membrane translocation, molecular dynamics, free energy calculations, fluorescent assays, mitochondrial carriers        ]]></keywords_en><summary_hr><![CDATA[Kontrolirani prijenos tvari preko staničnih membrana sastavljenih od lipida i proteina, ključan je za održavanje života. Osim pasivnog transporta koji se temelji na zakonima difuzije i uglavnom je neučinkovit u živim stanicama, aktivni transport potaknut ATP hidrolizom je neophodan za održavanje ionskog gradijenta kroz stanične membrane, volumena stanice, kao i za kontrolu brojnih biosintetskih putova. Međutim, treći vrlo bitan transportni mehanizam, koji djeluje kao kombinacija ova dva mehanizma, je pasivni transport uz pomoć membranskih proteina, ali bez potrebe za ATP-om. Ova vrsta transporta je uobičajena u prijenosu iona preko mitohondrijskih membrana, ali mehanizam kako membranski proteini kataliziraju inače spor prijenos iona bez dodatne energije nije dobro istražen i njegovo rasvjetljavanje bit će glavni cilj ovog prijedloga projekta. Budući da mnogi stanični procesi ovise o ovoj vrsti prijenosa kroz staničnu membranu, vrlo je važno razumjeti ih na molekulskoj razini budući da svaki poremećaj dovodi do energetske neravnoteže u mitohondrijima što zatim dovodi do raznih bolesti, kao što su rak, dijabetes, pretilost, Alzheimerova bolest, Parkinsonova bolest i druge. Cilj prijedloga projekta je povezivanje postojećih kvalitativnih slikovnih opisa fenomena translokacije preko staničnih membrana, s kvantitativnim i mjerljivim podacima na molekulskoj razini korištenjem suvremenih molekularnih simulacija, modelnih eksperimenata u liposomima i elektrofizioloških mjerenja u proteoliposomima. Istraživanje će ponuditi odgovore na brojna pitanja vezana uz zdravlje pružajući zajednici bolje razumijevanje temeljnih načela i mehanizma translokacije kroz stanične membrane. Znanje stečeno na tom putu pružit će snažne temelje u razvoju drugih, medicinski relevantnih otkrića, kao što je dizajn pametne isporuke lijekova uz pomoć prepoznavanja ključnih interakcija tijekom prijenosa preko staničnih membrana na molekulskoj razini.]]></summary_hr><summary_en><![CDATA[The controlled transport of matter across cell membranes composed of lipids and proteins, is vital for life sustaining. In addition to passive transport which is based on diffusion laws and largely ineffective in living cells, active transport driven by ATP hydrolysis is essential for maintaining ion gradients across cell membranes, cell volume as well as for controlling numerous biosynthetic pathways. However, a third highly relevant transport mechanism, acting as a combination of these two mechanisms, is passive transport assisted with membrane proteins but without the need for ATP. This type of transport is common in ion translocation across mitochondrial membranes, but the mechanism how membrane proteins catalyse otherwise slow transport of ions without additional energy is not well understood and its elucidation will be the main objective of this project proposal. Since many cell processes depend on this type of cell membrane transport, it is very important to understand it with molecular details, as any disruption of it leads to energetic misbalance in mitochondria leading to various diseases, such as cancer, diabetes, obesity, Alzheimer’s disease, Parkinson’s disease and others. The aim of the project proposal is to connect existing qualitative picturesque descriptions of cell membrane translocation phenomena, with quantitative, measurable and perceptible data at the molecular level using “state of the art” molecular simulations, model liposome experiments and electrophysiological measurements in proteoliposomes. The research will endorse health by providing the community with better understanding of the underlying principles and mechanisms of cell translocation mechanism. The knowledge gained along the way will provide strong foundations in development of other, more medicinally relevant discoveries, such as smart drug delivery design by identifying essential interactions of cell membrane transport at the molecular level.]]></summary_en></project><project>
<id>8388</id><title_hr><![CDATA[Multidisciplinarni pristup izradi  konceptualnih modela hidrotermalnih sustava]]></title_hr><title_en><![CDATA[Multidisciplinary Approach to Conceptual Modelling of Hydrothermal Systems]]></title_en><user_id>22782</user_id><user_firstLast_name>Staša Borović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2019-04</proposal_call><code>UIP-2019-04-1218</code><acronim><![CDATA[HyTheC]]></acronim><duration>17.02.2020 - 16.02.2025</duration><status>Završio</status><financ_value>259.229,15 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Rudarstvo, nafta i geološko inženjerstvo, </scie_field_hr><scie_field_en>Mining, petroleum and geological engineering, </scie_field_en><institution_hr><![CDATA[Hrvatski geološki institut]]></institution_hr><institution_en><![CDATA[Croatian Geological Survey]]></institution_en><team_members_id>5751, 6086, 5920, 858325, 25274, 864968, 864975, 12406, </team_members_id><team_members_names><![CDATA[Tihomir Frangen, Maja Briški, Kosta Urumović, Mirja Pavić, Marco Pola, Morena Mileusnić, Ivan Kosović Kosović, Bojan  Matoš, ]]></team_members_names><keywords_hr><![CDATA[hidrotermalni sustav, multidisciplinarni pristup, konceptualni model, numerički model, održivo korištenje]]></keywords_hr><keywords_en><![CDATA[hydrothermal system, multidisciplinary approach, conceptual model, numerical model, sustainable utilisation]]></keywords_en><summary_hr><![CDATA[Panonski dio Hrvatske ima povoljne geotermalne karakteristike, a prirodni izvori termalne vode (do 65°C) pojavljuju se na dvadesetak lokacija. Te se vode koriste tisućljećima, a u proteklih 50 godina predstavljaju ključni resurs turističkih i lječilišnih centara. Povećanje potražnje za termalnom vodom s vremenom je potaknulo crpljenje većih količina.Termalna izvorišta su dio hidrotermalnih sustava koji uključuju: područja prihranjivanja u zaleđima izvora; geotermalne vodonosnike (uglavnom mezozojske karbonatne stijene) u kojima se voda zadržava i zagrijava zbog toplinskog toka iz Zemlje; i područja istjecanja na mjestima povoljnih struktura veće propusnosti. Kontinuirano funkcioniranje sustava zavisi od osjetljive ravnoteže između brzine toka podzemne vode, procesa taloženja/otapanja i tektonskih pokreta. Kako bi se ona očuvala, i termalna izvorišta koristila na održiv način, potrebno je razumijevanje na razini sustava.Cilj projekta HyTheC je istražiti dinamiku fluida i topline u hidrotermalnim sustavima korištenjem multidisciplinarnog pristupa (hidrogeologija, hidrogeokemija, strukturna geologija, geofizička i daljinska istraživanja). Rezultati će se koristiti za izradu konceptualnih modela sustava, koji počivaju na 3D geološkim modelima i numeričkim simulacijama funkcioniranja sustava u prirodnim uvjetima i s različitim scenarijima crpljenja. Metodologija će se testirati u tri pilot područja u Hrvatskoj gdje se koriste termalne vode.Kvalitetni konceptualni i numerički modeli omogućuju ocrtavanje i zaštitu područja prihranjivanja i određivanje održivih crpnih količina, što je preduvjet za dugoročno održivo korištenje hidrotermalnih sustava.Mnogi europski i hrvatski strateški dokumenti predviđaju povećanje korištenja termalne vode. Stoga će HGI-CGS uspostaviti multidisciplinarnu istraživačku grupu koja će doprinijeti odgovornom korištenju hidrotermalnih sustava u Hrvatskoj, te biti znanstveno produktivna i konkurentna u prijavama na natječaje različitih programa.]]></summary_hr><summary_en><![CDATA[Pannonian part of Croatia has favourable geothermal characteristics and natural thermal springs (up to 65°C) appear at two dozen locations. These waters have been used for millennia, and in the past 50 years they are the basis for tourism and health care centres. As the water demand increased, higher quantities were abstracted.Thermal springs are part of hydrothermal systems which include: recharge areas in the hinterlands of springs; geothermal aquifers (mostly Mesozoic carbonate rocks) where water resides and heats up due to terrestrial heat flow; and discharge areas in places with structural characteristics of high permeability. Continuous functioning of systems depends on a delicate balance between groundwater flow velocities, precipitation/dissolution processes and tectonic movements. To maintain that balance and use thermal waters in a sustainable manner, a system-level understanding is required.The aim of HyTheC project is to investigate fluid and heat dynamics in hydrothermal systems using multidisciplinary approach (hydrogeology, hydrogeochemistry, structural geology, geophysics, and remote sensing). The results will be used to develop conceptual models of the systems that will benefit from 3D geological modelling and numerical simulations of system functioning in natural conditions and different pumping scenarios. The methodology will be tested in three pilot areas in Croatia where thermal water is used.Good conceptual and numerical models enable the delineation and protection of recharge areas and determination of sustainable pumping rates, which is the prerequisite for long-term sustainable use of hydrothermal resources.The increase in thermal water utilisation is foreseen by EU and Croatian strategic documents. Therefore the HGI-CGS will establish a multidisciplinary research group, which will contribute to the responsible development of hydrothermal systems in Croatia and will be scientifically productive and competitive in new calls for proposals.]]></summary_en></project><project>
<id>8390</id><title_hr><![CDATA[Simetrije u kvantnoj gravitaciji]]></title_hr><title_en><![CDATA[Symmetries for Quantum Gravity]]></title_en><user_id>52</user_id><user_firstLast_name>Larisa Jonke</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-4168</code><acronim><![CDATA[SYMM4QG]]></acronim><duration>01.03.2020 - 31.07.2024</duration><status>Završio</status><financ_value>130.068,35 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>5035, 22491, 26218, 855343, 861722, 862763, 865450, 867648, </team_members_id><team_members_names><![CDATA[Athanasios Chatzistavrakidis, Clay James Grewcoe, Marija Dimitrijevic  Ciric, Arash Ranjbar Zidehi, Georgios Manolakos, Toni Kodžoman, Eric Lescano, Sylvain Lavau, ]]></team_members_names><keywords_hr><![CDATA[dvostruka teorija polja, viša baždarna teorija, više grupe, Drinfeldov twist, L_infinity algebra]]></keywords_hr><keywords_en><![CDATA[double field theory, higher gauge theory, higher group, Drinfel&#39;d twist, L_infinity algebra]]></keywords_en><summary_hr><![CDATA[Važnost simetrija u istraživanjima u fizici ne može se prenaglasiti. Posebice, izniman uspjeh opće relativnosti u opisivanju prirode gravitacijske interakcije, što je potvrđeno u brojnim eksperimentima, temelji se na detaljnom razumijevanju fundamentalnih simetrija. Međutim, postoje jaki teorijski dokazi da je za opisivanje fizikalnih fenomena u kvantnoj gravitaciji nužno poopćiti dosad korištene principe simetrija. Predloženo istraživanje ima za cilj unaprijediti razumijevanje generaliziranih principa simetrije relevantnih za teoriju kvantne gravitacije kao jednog od temeljnih elemenata još nepoznate  teorije. Koristeći skup modela motiviranih teorijom struna kao približenje za kvantnu gravitaciju istražit ćemo relevantne strukture simetrije i njihove fizikalne implikacije. Očekujemo da će naši rezultati pridonijeti i formalnom matematičkom razumijevanju generaliziranih simetrija i razvoju konkretnog fizikalnog opisa fenomena kvantne gravitacije.]]></summary_hr><summary_en><![CDATA[The importance of symmetries in physics research cannot be overemphasized. In particular, the exceptional success of general relativity in describing the nature of gravitational interaction, as confirmed in numerous experiments, is based on thorough understanding of the underlying symmetries. However, there exists strong theoretical evidence that in order to describe physical phenomena in the quantum gravity regime one has to allow for more general symmetry structures. The proposed research aims at advancing our understanding of generalized symmetry principles relevant for a theory of quantum gravity as one of the building blocks of so far elusive theory. Using a set of models motivated by string theory as proxies for quantum gravity we shall investigate relevant symmetry structures and their physical implications. We expect that our result will contribute both to the more formal, mathematical understanding of generalized symmetries and to the development of concrete physical description of quantum gravity related phenomena.]]></summary_en></project><project>
<id>8392</id><title_hr><![CDATA[Raspadi i vremena života teških hadrona]]></title_hr><title_en><![CDATA[Heavy Hadron Decays and Lifetimes]]></title_en><user_id>2665</user_id><user_firstLast_name>Blaženka Melić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-7094</code><acronim><![CDATA[HHDeLi]]></acronim><duration>01.02.2020 - 21.07.2024</duration><status>Završio</status><financ_value>118.654,19 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>866160, 866657, 867383, </team_members_id><team_members_names><![CDATA[Ivan Nisandzic, Lovro Dulibić, Arslan Sikandar, ]]></team_members_names><keywords_hr><![CDATA[teorijska fizika elementarnih cestica, fizika teških hadrona, razvoj po masama teškog kvarka, inkluzivni raspadi, vremena života]]></keywords_hr><keywords_en><![CDATA[theoretical particle physics, heavy hadron physics, heavy quark expansion, inclusive decays, lifetimes]]></keywords_en><summary_hr><![CDATA[Vremena života teških hadrona, kao temeljna svojstva čestica, se dobivaju izračunom inkluzivnih širina raspada teških kvarkova koji su sustavno obrađeni u konzistentnom okviru poznatom kao razvoj po masi teškog kvarka (eng.HQE). Budući da su vezana stanja teškog kvarka i lakih konstituenata (mezoni, jednostruki c-(šarmantni) ili b-(beauty) barioni) ili dva teška kvarka i jednog lakog (dvostruki c-(šarmantni)  ili b-(beauty )barioni), teški hadroni sadrže meke stupnjeve slobode koji generiraju neperturbativne korekcije koje je teško izračunati. Novi eksperimentalni podaci, kako o c-hadronskim raspadima tako i o b-raspadima, omogućili su detaljnu usporedbu eksperimentalnih i teorijskih rezultata i otkrili su dobro slaganje uz nekoliko značajnih iznimaka: nedavna mjerenja vremena života  Ksi(c)+, Ksi(cc)++ i osobito, Omega(c)0  bariona se ne slažu s teorijskim predviđanjima. Stoga je potrebno pažljivo ispitati sve dijelove izračuna i odrediti ih vrlo precizno. Posebice, masa teškog kvarka nije dobro definirana veličina. Drugi glavni izvor neodređenosti je vrijednost valne funkcije teškog hadrona koja parametrizira doprinos operatora dimenzije 6 i viših, te dovodi do glavnih razlika u vremenima života. Neodređenosti koje nadilaze ove “prirodne neodređenosti ” smatraju se narušenjima kvark-hadronske dualnosti. Budući da je inverzna masa b-kvarka dobar parametar razvoja u raspadima b-hadrona, šarmantni hadronski raspadi ostaju kao najpogodniji za proučavanje i ispitivanje mogućeg narušenja kvark-hadronske dualnosti. Međutim, da bismo mogli razumjeti složenost barionskih valnih funkcija, b-barionski raspadi također mogu pružiti vrijedne informacije. Zbog svih gore navedenih činjenica, potrebno je ponovno detaljno razmotriti izračun vremena života teških hadrona i utvrditi pouzdane metode i modele koji se koriste u izračunu.]]></summary_hr><summary_en><![CDATA[The lifetimes of heavy hadrons, being the fundamental particle’s property, are obtained by calculating inclusive decays of heavy quarks which are  systematically treated in a consistent framework known as the heavy-quark expansion, HQE. Being the bound states of a heavy quark and light constituent (mesons, singly charmed/beauty baryons) or of two heavy quarks and one light constituent (doubly charmed/beauty baryons), heavy hadrons contain soft degrees of freedom which generate nonperturbative power corrections which are difficult to calculate. New experimental data, both on c-hadron decays and on b-decays, have made possible a detailed comparison of experimental and theoretical results and have revealed broad agreement with several notable exceptions: recent measurements of the Ksi(c)+, Ksi(cc)++ and in particular Omega(c)0  lifetimes do not agree with theoretical predictions. Therefore, one has to examine all ingredients of the calculation very carefully and to calculate them very precisely. In particular, the heavy quark mass is not a well defined quantity. The other main source of uncertainty is the value of the heavy hadron wave function which parametrizes the contribution of  dimension-6 operators and higher and leads to the main differences in the lifetimes. The uncertainties beyond these “natural uncertainties” are considered to be violations of quark-hadron duality. Since the inverse beauty quark mass appears to be a good expansion parameter in beauty decays the charmed hadron decays are left as a playground for studying and testing of the possible violation of the quark-hadron duality. However, to be able to understand the complexity of baryonic wave functions, the beauty baryon decays can provide valuable information too. Due to the all facts said above, it is timely to revisit the calculation of the heavy hadron lifetimes and to establish the reliable methods and models used in the calculation.]]></summary_en></project><project>
<id>8394</id><title_hr><![CDATA[Mehanokemijska aktivacija i funkcionalizacija veze C–H  potaknuta paladijem i usmjerena ligandom]]></title_hr><title_en><![CDATA[Palladium-Mediated Ligand-Directed C–H bond  Activation and Functionalization by Mechanochemistry]]></title_en><user_id>112</user_id><user_firstLast_name>Manda Ćurić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-9951</code><acronim><![CDATA[MECHEMFUN]]></acronim><duration>15.01.2020 - 14.06.2024</duration><status>Završio</status><financ_value>132.682,99 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>854, 1007, 3061, 21393, 21286, 862798, </team_members_id><team_members_names><![CDATA[Darko Babić, Marina Juribašić Kulcsar, Ana Budimir, Dajana Barišić, Alen Bjelopetrović, Mario Pajić, ]]></team_members_names><keywords_hr><![CDATA[mehanokemija, veza C–H, aktivacija, funkcionalizacija, katalizatori paladija(II), spektroskopije Raman, IR i NMR,  PXRD]]></keywords_hr><keywords_en><![CDATA[mechanochemistry, C–H bond, activation, functionalization, palladium(II) catalysts,  Raman, IR and NMR spectroscopies, PXRD ]]></keywords_en><summary_hr><![CDATA[Razvoj metoda za izravnu i selektivnu zamjenu inertne veze C–H, vezama C–O, C–X, C–N, C–S i C–C od iznimne je važnosti za organsku sintezu. Ove kemijske transformacije još uvijek se pretežno oslanjaju na protokole na bazi otapala koji su često dugotrajni i redovito zahtijevaju otrovna otapala.Cilj predloženog projekta je razvoj i optimizacija metoda u čvrstom stanju, zasnovanih na mljevenju reaktanata, za funkcionalizaciju veze C–H usmjerenu ligandom i kataliziranu različitim prekursorima s paladijem(II). Ovaj cilj postići će se upotrebom supstrata s donorskom skupinom koja se veže na metalni centar i dovodi ga u blizinu specifične veze C–H. U procesu poznatom kao aktivacija veze C-H ili ciklometalacija nastaje paladaciklički međuprodukt formiranjem veze C–Pd. Veza C–Pd daleko je reaktivnija od veze C–H, pa se reakcijom s odgovarajućim sekundarnim supstratom može postići njena pretvorba u drugu željenu vezu: C–O, C–X, C–N, C–S ili C–C. Prije transformacije veze C-H u druge funkcionalne skupine, bit će izveden niz reakcija između paladijevih(II) prekursora i supstrata s različitim donorskim skupinama na sobnoj i povišenoj temperaturi kako bi se dobili paladaciklički međuprodukti te definirali najprikladniji uvjeti aktivacije. Stečena saznanja bit će primijenjena za funkcionalizaciju veze C–H u istim supstratima, pomoću uobičajenih oksidansa i/ili partnera za spajanje, u prisutnosti katalitičkih količina paladijevih(II) prekursora. Sve reakcije pratit će se in situ Ramanovom spektroskopijom, koja će u kombinaciji s ex situ NMR, IR i X-ray eksperimentima, omogućiti karakterizaciju reakcijskih vrsta, izravan uvid u dinamiku i reakcijske putove, te optimizaciju procesa mljevenja. Rezultati predloženih istraživanja omogućit će detaljan uvid u mehanokemijsku funkcionalizaciju veze C–H kataliziranu različitim spojevima paladija(II), te će potaknuti razvoj učinkovitijih paladijevih katalizatora i daljnju primjenu mehanokemije u kemijskoj sintezi.]]></summary_hr><summary_en><![CDATA[Development of methods for the direct and selective replacement of inert C–H bond by C–O, C–X, C–N, C–S, or C–C bonds is of immense importance for organic synthesis. Currently, these processes still rely predominantly on solvent-based protocols which often require toxic solvents and are time-consuming.The objective of the proposed project is to develop and optimize ball milling methods for the ligand-directed C–H bond functionalization mediated by various Pd(II) catalytic precursors. This objective will be achieved by using substrates with a donor group which binds and positions the Pd(II) centre near the specific C–H bond. In the process known as C–H bond activation, the palladacyclic intermediate is produced by forming the C–Pd bond. The resulting C–Pd bond, which is far more reactive than its C–H predecessor, reacts with the secondary substrate to produce the targeted C–C, C–X, C–N, C–S, or C–C bonds. Prior to the transformation of C–H bonds to other functional groups, a series of ball-milling reactions between common Pd(II) precursors and substrates with different donor groups will be performed at variable temperatures to obtain intermediate palladacycles and define the most suitable activation conditions. The acquired knowledge will be applied in C–H bond functionalization of the same substrates with commonly used oxidants and/or coupling partners in the presence of a catalytic amount of Pd(II) precursors. The reactions will be monitored in situ by Raman spectroscopy, and ex situ by NMR, IR spectroscopies and X-ray diffraction for characterization of the participating reaction species, direct insight into the reaction pathways, and optimization of the milling process.The proposed study will provide a detailed insight into mechanochemical ligand-directed C–H bond functionalization catalysed by Pd(II) compounds, promote the development of more efficient catalysts as well as provide further applications of mechanochemistry in chemical synthesis.]]></summary_en></project><project>
<id>8397</id><title_hr><![CDATA[Moždani izvanstanični matriks u razvitku i perinatalnoj hipoksiji]]></title_hr><title_en><![CDATA[Brain extracellular matrix in development and in perinatal hypoxia]]></title_en><user_id>6256</user_id><user_firstLast_name>Nataša Jovanov Milošević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-3182</code><acronim><![CDATA[BRAINECM]]></acronim><duration>01.03.2020 - 30.06.2024</duration><status>Završio</status><financ_value>198.445,27 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, Clinical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>2567, 5314, 26275, 26263, 3483, 17812, 22600, 25418, 26092, 26265, 23892, 22574, 865159, </team_members_id><team_members_names><![CDATA[Zdravko Petanjek, Dubravka Hranilović, Davor Petrović, Ivana Pogledić, Sanja Darmopil, Vinka Knezović, Mihaela Bobić Rasonja, Sara Trnski, Ivan Banovac, Nataliya Di Donato, Marija Milković Periša, Barbara Nikolić, Matea Drlje, ]]></team_members_names><keywords_hr><![CDATA[perineuronske mreže, interneuroni, razvojne fetalne zone, lektikani, MRI]]></keywords_hr><keywords_en><![CDATA[perineuronal nets, interneurons, devlopmental zones, lecticans, MRI]]></keywords_en><summary_hr><![CDATA[Unatoč dostignućima u razumijevanju važnosti neuralnog izvanstaničnog matriksa (ECM, difuznog ili kondenziranog kao perineuronske mreže - PNN) za fiziološke i patološke procese u mozgu, on je još uvijek daleko manje prepoznat i istražen od staničnih elemenata. U cilju novih spoznaja o ključnim molekulama i razvojnim događajima u ECM-u, posebno onih koji su izraženi u ljudskom mozgu, istraživači sa HIIM-a, Zagreba i Tehničkog Sveučilišta u Dresdenu,  sa kliničarima-istraživačima sa KBC Zagreb i AKH, Sveučilišta u Beču će ujediniti znanstvene pristupe, modele (ljudski, štakorski i organoidi) i metodologije (3T I 7T MRI, histološke, molekularne, bihevioralne) kako bi se odgovorilo na sljedeće znanstvene ciljeve: (1) otkriti značajne razlike u sastavnicama ECM-a između fetalnih zona, odjeljaka, aksonskih (strata) i kortikalnih (layers) slojeva; (2) otkriti obrasce ekspresije molekula ECM-a telencefaličke stjenke i bazalnih ganglija u razvitku; (3) definirati ključne vremenske točke ireverzibilnih promjena ekspresijskih obrasca ECM-a prijelazom u juvenilni oblik ECM-a; (4) otkriti korelate fetalnih ECM obrazaca na slikovnim prikazima MRI u zdravlju (humani i štakorski model) i nakon perinatalne hipoksije (štakorski model); (5) otkriti staničnu i prostorno vremensku distribuciju PNN-a i njihove molekularne značajke u razvitku i nakon perinatalne hipoksije (štakora); (6) i korelirati ih sa bihevioralnim posljedicama hipoksije. Očekujemo da će istraživanje omogućiti da procijenimo značaj i ulogu molekula, obrazaca i reorganizacijskih procesa moždanog ECM-a. Rezultati projekta biti će nove znanstvene spoznaje, publikacije, unapređenje edukacije i pozicioniranje za daljnje međunarodne projekte usmjerene na razvoj novih ECM-baziranih istraživanja, dijagnostičkih i terapijskih strategija za neurorazvojne poremećaje kao što su kognitivni deficit, epilepsija, autizam ili shizofrenija.]]></summary_hr><summary_en><![CDATA[Despite recent advances in the understanding of the importance of the neural extracellular matrix (ECM,  diffused or condensed as perineuronal nets, PNN) for physiological and pathological processes in the brain, it is still widely less recognized and researched than different neural cellular elements. To combat the lack of knowledge on key ECM players relevant for human brain development, basic researchers (at CIBR, Zagreb, and TU, Dresden) and clinical oriented researchers (at CHC Zagreb, AKH Vienna and TU Dresden) will unite scientific approaches, models (human, rat, and organoids) and methodologies (3T and 7T MRI, histological, molecular and behavioural), to address the following scientific aims: (1) to detect major differences in ECM constituents among the fetal brain zones, compartments, axonal strata, and cortical layers; (2) to disclose the different ECM expression patterns in the developing brain;  (3) to define the crucial time points of ECM expression patterns irreversible up-turns in transition to juvenile ECM form; (4) to reveal the correlates of the fetal ECM patterns in high-resolution MRI in health (human, rat) and after perinatal hypoxia (rat); (5) to disclose cellular and spatial-temporal distribution, and molecular determinants of the PNN in health (human and rat) and after perinatal hypoxia (rat); and  to correlate them to behavioural consequences of hypoxic ECM lesion (rat). These will enable us to evaluate the significance and the role of ECM constituents, and ECM reorganization, for the developmental processes (proliferation, migration, axon growth, folding, and synaptogenesis) in the human brain, in health and disorders. The outcome of the project will be new knowledge, publications, advances in education, and positioning for joint international proposals towards ECM-based research, diagnostic and therapeutic strategies, for neurodevelopmental disorders as cognitive disabilities, epilepsy, autism or schizophrenia.]]></summary_en></project><project>
<id>8399</id><title_hr><![CDATA[Robusno kodiranje strukturiranog svjetla za 3D oslikavanje u teškim uvjetima]]></title_hr><title_en><![CDATA[Robust Structured Light Coding for 3D Imaging in Difficult Conditions]]></title_en><user_id>6641</user_id><user_firstLast_name>Tomislav Petković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-9157</code><acronim><![CDATA[3D-CODING]]></acronim><duration>01.02.2020 - 28.06.2024</duration><status>Završio</status><financ_value>126.816,64 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, Računarstvo, </scie_field_hr><scie_field_en>Electrical engineering, Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>6456, 6426, 23587, 27173, 7677, 864843, </team_members_id><team_members_names><![CDATA[Tomislav Pribanić, Antonio Vasilijević, Simone Gasparini, Josep Forest, Joaquim Salvi, Domagoj Zoraja, ]]></team_members_names><keywords_hr><![CDATA[strukturirano svjetlo, funkcije kodiranja, kalibracija projektora, podvodno 3D skeniranje, računalno oslikavanje]]></keywords_hr><keywords_en><![CDATA[structured light, coding functions, projector calibration, underwater 3D scanning, computational imaging]]></keywords_en><summary_hr><![CDATA[Površinsko 3D skeniranje korištenjem strukturiranog svjetla (SL) ima brojne primjene što između ostalog uključuje industrijsku metrologiju, skeniranje ljudskog tijela, dokumentiranje kulturne baštine i senziranje za robote. U skeniranju SL-om aktivni izvor svjetla osvjetljava neki objekt koristeći odabrani uzorak kojeg snima kamera. Dekodiranje snimljenog uzorka omogućuje rekonstrukciju površinskog profila kroz triangulaciju. Ključna komponenta uspješnog 3D skeniranja je odabrani uzorak SL-a i pripadna funkcija kodiranja. Većina postojećih skenera koji koriste SL, i komercijalnih i znanstvenih, je ograničena na 3D oslikavanje površine u kontroliranim uvjetima kao što je tamna soba gdje su interferencije i ostali neželjeni efekti zanemarivi. Otklanjanje takvih ograničenja i omogućavanje upotrebe 3D skeniranja izvan laboratorija zahtijeva dizajniranje novih uzorke SL-a i pripadne novih funkcija kodiranja. Taj istraživački cilj je sažeto opisan sljedećim prilično teškim istraživačkim pitanjem: „Koje su optimalne funkcije kodiranja?“. Cilj ovog projekta je ostvariti i teorijski i primijenjeni doprinos koji će nas približiti odgovoru na to pitanje. U okviru projekta će se istraživati robusne funkcije kodiranja za površinsko 3D oslikavanje u teškim uvjetima. Teški uvjeti koji će biti razmatrani uključuju globalnu interferenciju u obliku izravnog sunčevog svjetla i problem oslikavanja SL-om u raspršujućoj okolini što se najbolje istražuje na problemu podvodnog skeniranja u bistroj i mutnoj vodi. Očekivani teorijski doprinos je multidisciplinaran i upada presjek polja obrade signala, računalnog vida i optike a tiče se dizajna robusnih funkcija kodiranja za 3D oslikavanje. Očekivani primijenjeni doprinos je napravljen sustav za 3D skeniranje na otvorenom i pod vodom čija uporabnost je eksperimentalno potvrđena.]]></summary_hr><summary_en><![CDATA[Surface 3D scanning using structured light (SL) has numerous applications including among others industrial metrology, human body scanning, documenting cultural heritage and robot sensing. In SL scanning an active light source illuminates an object using a specific pattern which is observed by a camera. Decoding the observed pattern enables surface profile recovery via triangulation. The key to the successful 3D scanning is the selected SL pattern and the associated coding function. Most of the existing SL scanners, both commercial and scientific, are limited to 3D surface imaging in controlled environments such as dark rooms where interferences and other unwanted effects are negligible. To mitigate current limitations and to bring the 3D scanner outside of the lab novel SL patterns and associated novel coding functions must be designed. This research goal is summarized by the following quite difficult question: “What are the optimal coding functions?”. The aim of this project is to produce both theoretical and applied contribution which will bring us closer to answering this question. In this project robust coding functions for 3D surface imaging in difficult conditions will be investigated. The difficult conditions which will be considered include global interference in the form of direct sunlight and the problem of SL imaging in scattering media which is best investigated in an underwater scanning scenario including both clear and turbid water. The expected theoretical contribution is multi-scope as it falls at the intersection of signal processing, computer vision and optics and concerns the design of robust coding functions for 3D imaging. The expected applied contribution is a working system for 3D scanning in the open and underwater whose operation is experimentally verified.]]></summary_en></project><project>
<id>8402</id><title_hr><![CDATA[Biougljen kao ekološki prihvatljiv i održiv način upravljanja ishranom vinove loze u kontekstu klimatskih promjena]]></title_hr><title_en><![CDATA[Biochar as a tool for environment-friendly and sustainable grapevine nutrient management in the context of climate change]]></title_en><user_id>3037</user_id><user_firstLast_name>Igor Palčić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2019-04</proposal_call><code>UIP-2019-04-7370</code><acronim><![CDATA[BIONUTRIVINE]]></acronim><duration>01.01.2020 - 30.06.2025</duration><status>Završio</status><financ_value>263.627,31 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Institut za poljoprivredu i turizam]]></institution_hr><institution_en><![CDATA[Institute of Agriculture and Tourism in Poreč]]></institution_en><team_members_id>12403, 19688, 22830, 855798, 12801, 865077, 22828, </team_members_id><team_members_names><![CDATA[Igor Pasković, Zoran Užila, Danko Cvitan, Dominik Anđelini, Ivan Nemet, Melissa Prelac, Nikola Major, ]]></team_members_names><keywords_hr><![CDATA[biougljen, GHG emisije, hraniva, klimatske promjene, vinova loza]]></keywords_hr><keywords_en><![CDATA[biochar, climate change, GHG emissions, grapevine, nutrients]]></keywords_en><summary_hr><![CDATA[Konvencionalno vinogradarstvo može dovesti do degradacije tala u smislu gubitka organske tvari tla, zbijanja tla i smanjene infiltracije vode, smanjenja sadržaja hraniva i akumulacije teških metala. S druge strane, znanstveni dokazi ukazuju da klimatske promjene predstavljaju dominantan izazov za vinogradarstvo u nadolazećim desetljećima, budući da emisije stakleničkih plinova, temperatura, oborine i drugi čimbenici mogu izravno utjecati na ekosustave. Predloženo istraživanje ima za cilj integrirati alate za ublažavanje ova dva vrlo aktualna problema globalnog vinogradarstva - klimatske promjene i degradaciju tla, koristeći koncept kružne ekonomije i valorizacije otpada, putem korištenja ostataka rezidbe vinove loze i njihovu transformaciju u biougljen. Cilj predloženog istraživanja je postići: moguće smanjenje emisije stakleničkih plinova u vinogradima; ublažavanje stresa od suše poboljšanjem kapaciteta tla za vodu; i održivo upravljanje ishranom vinove loze vraćanjem hraniva koja bi se inače nepovratno iznijela tijekom rezidbe. Nadalje, prema dostupnoj literaturi,  ovo će biti prvi eksperiment dugotrajne primjene biougljena u vinogradarskim tlima koje će istražiti i utjecaj na kvalitetu vina. Glavni elementi predloženog projekta su: a) prikupljanje i karakterizacija ostataka rezidbe vinove loze; b) laboratorijska proizvodnja i karakterizacija biougljena iz ostataka ostataka rezidbe (PRDB); c) proizvodnja i karakterizacija većih količina PRDB-a za primjenu u vinograd; d) stacionarni pokus u vinogradu (pet tretmana - PRDB, PRDB obogaćen UREA-om, ostaci rezidbe, gnojivo i kontrola; tri vegetacije će biti obrađene projektom, ali eksperiment će se nastaviti i nakon završetka projekta); e) eksperiment s folijarnim tretmanima (s ciljem razvoja novog proizvoda). Rezultati projekta bit će od praktične važnosti za poljoprivredni i vinogradarski sektor te obećavajući alat za ekološki prihvatljivo i održivo upravljanje ishranom vinove loze i ublažavanje klimatskih promjena.]]></summary_hr><summary_en><![CDATA[Conventional viticulture can lead to the degradation of soils in terms of soil organic matter loss, compaction and reduced water infiltration, reduction of nutrient content and heavy metal accumulation. On the other hand, scientific evidence sharply states that climate change represents a dominant challenge for viticulture in the upcoming decades, since GHG emission, temperature, precipitation, and other factors can directly impact ecosystems. The proposed research aims to integrate the tools for possible mitigation of this two present problems for global viticulture – climate change and soil degradation, using the concept of circular and zero-waste economy, via the valorization and utilization of grapevine pruning residues by their transformation into biochar. The proposed research aims to achieve: the possible reduction of vineyard GHG emissions; alleviation of drought stress by improving soil water holding capacity; and sustainable grapevine nutrient management by giving back the nutrients which will be otherwise lost during pruning. Furthermore, to our knowledge it will be the first experiment on biochar long-term vineyard soil application researching also the effect on wine quality. The main elements of the proposed project are: a) grapevine pruning residues collection and characterization; b) pruning-residues-derived biochar (PRDB) laboratory production and characterization; c) PRDB field-scale production and characterization; d) vineyard long-term experiment (five treatments – PRDB, PRDB enriched with UREA, pruning residues, fertilizer and control; three growing seasons are part of the project, but the experiment will continue after the end of the project); e) foliar treatments experiment (with the aim to develop a new product). The outcomes of the project will be of practical importance to the agricultural and viticultural sector and a promising tool towards environment-friendly and sustainable grapevine nutrient management and climate change mitigation.]]></summary_en></project><project>
<id>8408</id><title_hr><![CDATA[Formuliranje, priprema i testiranje biopolimernih gelova kao nositelja bioaktivnih i hlapljivih komponenata u inovativnim funkcionalnim proizvodima]]></title_hr><title_en><![CDATA[Design, fabrication and testing of biopolymer gels as delivery systems for bioactive and volatile compounds in innovative functional foods ]]></title_en><user_id>7246</user_id><user_firstLast_name>Mirela Kopjar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-5749</code><acronim><![CDATA[bioACTIVEgels]]></acronim><duration>01.01.2020 - 31.12.2023</duration><status>Završio</status><financ_value>129.195,43 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Prehrambena tehnologija, </scie_field_hr><scie_field_en>Food technology, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Prehrambeno-tehnološki fakultet]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Food Technology]]></institution_en><team_members_id>7296, 7330, 25662, 25600, 26271, 856299, 866629, </team_members_id><team_members_names><![CDATA[Anita Pichler, Josip Simunovic, Josipa Vukoja, Vanja Kelemen, Ivana Ivić, Ina Ćorković, Ivana Buljeta, ]]></team_members_names><keywords_hr><![CDATA[Biopolimerni gelovi, bioaktivne komponente, hlapljive komponente, mikrovalovi, trehaloza, inovativni proizvodi]]></keywords_hr><keywords_en><![CDATA[Biopolymer gels, bioactive compounds, volatile compounds, microwave, trehalose, innovative products]]></keywords_en><summary_hr><![CDATA[Gelovi imaju široku primjenu, koriste se u proizvodnji prehrambenih proizvoda, farmaceutskih i različitih neprehrambenih proizvoda. Tradicionalni prehrambeni gelovi koji se najčešće proizvode, ali i koriste, su džemovi, marmelade, želei, slatkiši, voćni namazi, voćna punila. Osim u pripremi tradicionalnih proizvoda, gel-strukture se mogu formirati pomoću biopolimera s ciljem uklapanja i enkapsulacije bioaktivnih sastojaka i hlapljivih komponenata (ciljanih komponenata u ovom projektu). Tako dobivene gel-strukture mogu se koristiti za razvoj inovativnih, funkcionalnih proizvoda. Uz poboljšanje tradicionalnih prehrambenih gelova, istraživanja ćemo usmjeriti i na razvoj novih tzv. hidrogelova kao nositelja ciljanih komponenata. I bioaktivne i hlapljive komponente su vrlo važne za kvalitetu voća i proizvoda od voća obzirom da su odgovorne za boju, aromu, antioksidacijsku aktivnost te posjeduju potencijalni pozitivni učinak na zdravlje. Najveći problem je njihova nestabilnost. Hidrogelovi mogu biti vrlo korisni u razvoju tzv. „delivery by design“ koncepta jer tvore mrežu koja može fizički i/ili kemijski zarobiti bioaktivne i hlapljive komponente a isključujući dehidrataciju (popularnu za njihovu enkapsulaciju) koja može biti vrlo skupa. Oba tipa gelirani proizvoda pripremat će se od prehrambenih biopolimera. Biopolimeri mogu biti različitih struktura i fizikalno-kemijskih svojstava (npr. molekulske mase, naboja, razgranatosti, fleksibilnosti, polarnosti, topljivosti) te ovisno o svojstvima dolazi do njihovog povezivanja u koloidalne čestice koje mogu imati različita funkcionalna svojstva. Pažljivi odabir i balansiranje odgovarajućih biopolimera, sastav matriksa i metode pripreme, omogućuju formuliranje novih proizvoda odgovarajućih svojstava. Za pripremu gelova korist će se polisaharidi i/ili proteini. Dodatno, kako bi se postigla stabilnost bioaktivnih i hlapljivih komponenata korist će se tretiranje mikrovalovima (blagi proces) i dodatak trehaloze (stabilan šećer). ]]></summary_hr><summary_en><![CDATA[Gels have broad field of applications, from food products to pharmaceuticals, medicinal and non-food products. Traditional food gels that are very often prepared and used are jams, marmalades, jellies, sweets, fruit spreads, fruit fillings. Next to traditional application, gel-like structures can be formed by some biopolymers with the aim of inclusion and encapsulation of bioactive ingredients and volatile compounds (targeted compounds in this project), making them very attractive for immobilization of those compounds for development of innovative functional foods. Next to improvement of traditional gel products, we will concentre on development of hydrogels as delivery systems of targeted compounds. Both, bioactive and volatile compounds are very valuable for quality of fruit and fruit products since they are responsible for colour, flavour, antioxidant activity and poses health benefits. The major problem is their instability. Hydrogels could be quite useful for further growth of “delivery by design” concept, since they form network that can physically and/or chemically entrap bioactive and volatile compounds excluding dehydration step (popular tool for their encapsulation) that can be quite expensive. Both type of gelled products will be prepared with food biopolymers. Food biopolymers are having a diverse range of molecular and physicochemical properties (e.g. molecular weight, charge, branching, flexibility, polarity, solubility) allowing association of colloidal particles which have a broad range of functional attributes. Through careful selection and balancing of appropriate biopolymers, matrix composition and association methods, novel products with desired properties and behaviour can be formulated. For preparation of gel-structured products, polysaccharides and/or proteins will be used. Additionally, in order to improve stability of bioactive and volatile compounds, microwave treatment as mild process and/or trehalose as stable sugar will be applied. ]]></summary_en></project><project>
<id>8411</id><title_hr><![CDATA[Vulkano-sedimentne sukcesije sjeverozapadne Hrvatske i njihova uloga u razumijevanju geodinamike Paleotetisa tijekom srednjeg trijasa]]></title_hr><title_en><![CDATA[Revealing the Middle Triassic Paleotethyan geodynamics recorded in the volcano-sedimentary successions of NW Croatia]]></title_en><user_id>3342</user_id><user_firstLast_name>Damir  Slovenec</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-3824</code><acronim><![CDATA[GOST]]></acronim><duration>01.12.2019 - 30.11.2023</duration><status>Završio</status><financ_value>67.565,86 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Geologija, </scie_field_hr><scie_field_en>Geology, </scie_field_en><institution_hr><![CDATA[Hrvatski geološki institut]]></institution_hr><institution_en><![CDATA[Croatian Geological Survey]]></institution_en><team_members_id>4105, 4618, 23440, 4014, 23479, 5911, 13250, 3796, 855886, 864929, </team_members_id><team_members_names><![CDATA[Mirko Belak, Špela Goričan, Tonći Grgasović, Marija Horvat, Tea Kolar-Jurkovšek, Duje Smirčić, Branimir Šegvić, Duje Kukoč, Matija Vukovski, Luka Badurina, ]]></team_members_names><keywords_hr><![CDATA[srednji trijas, vulkano-sedimentne sukcesije, Paleotetis, mineraloško-petrološko-geokemijska karakerizacija, sedimentološka i paleontološka interpreta]]></keywords_hr><keywords_en><![CDATA[Middle Triassic, volcano-sedimentary successions, Paleotethys, mineralogical-petrological-geochemical characterization, sedimentological and palaeonto]]></keywords_en><summary_hr><![CDATA[Budući da se u zapadnom dijelu Paleotetisa vezanom za Alpsko-Karpatsko-Dinaridsko područje tijekom srednjeg trijasa duž kontinentalnih rubova karbonatne platforme odvijala intenzivna magmatska aktivnost, istraživanje vulkano-sedimentnih sukcesija od iznimnog je značaja za rješavanje geodinamike zbivanja. Područje istraživanja ovog projekta uključuje niz gora SZ Hrvatske (Ivanščica, Strahinjščica, Kuna gora, Desinić gora, Ravna gora, Žumberačka gora). Težište istraživanja bit će usmjereno na efuzive i vulkanoklastite interstratificirane u srednjotrijaskim marinskim sedimentnim stijenama. Cilj nam je sustavno proučiti vulkansko-sedimentne asocijacije iz perspektive različitih geoloških disciplina slijedeći suvremeni pristup kroz koji ćemo integrirati mineraloške, petrološke, geokemijske, paleontološke, sedimentološke, izotopne i strukturne podatke kako bi smo razjasnili tektonsku povijest područja. Rezultati će biti dobiveni upotrebom različitih analitičkih metoda i tehnika, uključujući i određivanje izotopne starosti. Analizom i sintezom rezultata  razjasnit će se geneza, karakter, podrijetlo i vrijeme kristalizacije primarnih magmi, zatim rekonstruirati geotektonski okoliši nastanka vulkanskih/vulkanoklastičnih stijena, te pružiti uvid u fizikalno-kemijske uvjete u kojima se zbivalo postkonsolidacijsko trošenje i dijagenetski procesi. Sedimentološkim analizama definirat će se okoliši i uvjeti taloženja vulkano-sedimentnih naslaga, a biostratigrafskim podacima i izotopnim datiranjem nastojat će se odrediti stratigrafski raspon vulkanske aktivnosti. Rezultati će omogućiti nove spoznaje o pojavnosti, načinu, uvjetima i vremenu postanka istraživanih vulkano-sedimentnih sukcesija sjeverozapadne Hrvatske. Takav pristup će u konačnici dovesti do kronološke rekonstrukcije tektonomagmatske evolucije tijekom donjeg mezozoika, što će poslužiti kao okvir za novi jednoznačni petrogenetsko-sedimentološki model razvoja geoloških zbivanja tijekom razdoblja srednjeg trijasa. ]]></summary_hr><summary_en><![CDATA[During middle Triassic, the area of western Paleotethys, specifically the Alpine-Dinaride-Carpathian System, experienced intensive magmatic activity along the carbonate platform margins. Accordingly, understanding the volcano-sedimentary successions is key knowledge to unveil the geodynamics. This project will, therefore, focus on area encompasses the mountain range of NW Croatia (Ivanščica Mt., Strahinjščica Mt., Kuna gora Mt., Desinić gora Mt., Ravna gora Mt., Žumberačka gora Mt.). The focus of this proposal is volcanic/volcaniclastic rocks interstratified within middle Triassic marine sedimentary sequences. We aim to study the volcano-sedimentary associations from the perspective of various geological sub-disciplines following a modern approach where we will integrate mineralogical, petrological, geochemical, paleontological, sedimentological, isotopic and structural data to illuminate the tectonic history of the area. Data will be acquired using multiple analytical methods and techniques  along with the radiometric dating. Processing and synthesis of results will shed light on genesis, characterization and crystallization time of primary magmas. It will furthermore enable reconstruction of the geotectonic setting of the formation of the volcanic rocks and will provide insights into physico-chemical conditions of post-consolidation weathering and diagenetic processes. Sedimentological analyses will be performed in order to define depositional environments of volcano-sedimentary deposits, whereas biostratigraphic and isotopic data will constrain stratigraphic span of volcanic activity. Results will enable new inferences on the occurrences as well as modes, conditions, and time of formation of volcano-sedimentary successions. Such approach will eventually lead to chronological reconstruction of tectono-magmatic evolution during the inception of Mesozoic, which will serve as the framework for a new petrogenetic and sedimentological model for the middle Triassic. ]]></summary_en></project><project>
<id>8414</id><title_hr><![CDATA[Istraživanje molekularnih i funkcionalnih svojstava glavnih regulatora aktivnosti stanica NK]]></title_hr><title_en><![CDATA[Elucidation of molecular and functional properties of master regulators of NK cell activation]]></title_en><user_id>19730</user_id><user_firstLast_name>Vedrana Jelenčić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2019-04</proposal_call><code>UIP-2019-04-9390</code><acronim><![CDATA[NK-MASTERS]]></acronim><duration>01.01.2020 - 31.05.2025</duration><status>Završio</status><financ_value>264.888,18 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Medicine]]></institution_en><team_members_id>19672, 855404, </team_members_id><team_members_names><![CDATA[Maja Lenartić, Vanna Imširović, ]]></team_members_names><keywords_hr><![CDATA[CD16, MCMV, NCR1, NKG2D, stanice NK, tumori,]]></keywords_hr><keywords_en><![CDATA[CD16, MCMV, NCR1, NKG2D, NK cells, tumours, ]]></keywords_en><summary_hr><![CDATA[Stanice NK kao dio prirođene imunosti imaju važnu ulogu u ranoj obrani organizma protiv raznih infekcija i tumora. One reagiraju na stanični stres te su bez prethodne senzibilizacije sposobne brzo eliminirati potencijalno opasne stanice , pošteđujući zdrave. Ne pravovremena aktivacija stanica NK je posebno opasna jer može dovesti do razorne auto-imunosti. Kako bi se to spriječilo stanice NK na svojoj površini izražavaju čitav niz aktivacijskih i inhibicijskih receptora. Ravnoteža signala koju stanica primi preko njih određuje hoće li doći do aktivacije. Međutim, tri aktivacijska receptora izražena na svim stanicama NK, NKG2D, CD16 i NCR1 nemaju svog inhibicijskog protu-regulatora te su naizgled oslobođeni regulacije aktivacije preko ravnoteže signala. Zbog toga mi pretpostavljamo da regulacija preko samo ravnoteže signala nije dovoljno osjetljiva da bi se postigla maksimalna aktivnost stanica NK, već da postoji potreba za dodatnim &#39;glavnim signalom&#39; preko NKG2D, CD16 ili NCR1 receptora. Upravo to i želimo istražiti u predloženom projektu. Korištenjem genetički modificiranih mišjih sojeva kojima nedostaje izražaj pojedinog, kombinacije ili sva tri navedena aktivacijska receptora ispitati ćemo utjecaj na kontrolu virusne infekcije i tumora. Također, koristeći polikromatsku protočnu citometriju u kombinaciji s raznim in vitro i in vivo metodama istražiti ćemo utjecaj ovih receptora na razvoj, signaliranje te efektorske funkcije stanica NK. Korištenjem visokoprotočne analize transkriptoma planiramo identificirati i analizirati molekularni potpis pojedinačnih glavnih regulatora. Rezultati ovog istraživanja omogućiti će bolje razumjevanje temeljne biologije stanica NK. Također, naši rezultati rasvjetljavanjem mehanizama koji dovode do aktivacije stanica NK mogu doprinjeti napretku razvoja imunoterapije bazirane na stanicama NK.]]></summary_hr><summary_en><![CDATA[NK cells, as part of innate immunity, play an important role in the early defence against infections and tumours. NK cells can respond to cellular threats without prior sensitization and are able to rapidly eliminate potentially dangerous cells whilst sparing healthy ones. Inappropriate NK cell activation is therefore particularly dangerous as it may lead to devastating auto-immunity. To prevent this from happening, NK cells express a large number of activating and inhibitory receptors on their surface. The balance of signals received through these proteins determines whether or not an NK cell gets activated. However, three activating receptors expressed on all NK cells, i.e. NKG2D, CD16 and NCR1, lack an inhibitory counter-regulator and are therefore seemingly exempt of balance-mediated activation of NK cell activation. We therefore hypothesize that the balance between inhibitory and activating signals is not sensitive enough to induce full activation of NK cells and that there is an additional requirement for a ‘master signal’ through NKG2D, CD16 or NCR1 in order to gain maximal NK cell reactivity. This question we plan to address in the proposed project. We plan to use genetically modified mouse models lacking individual, combination or all three activating receptors and investigate how it influence control of viral infection and tumours. In addition, using multipanel flow cytometry in combination with different in vitro and in vivo methods we plan to investigate how lack of this receptors influence development, signalling and effector functions of NK cells. Also, by using high-throughput transcriptome analysis we plan to identify and analyse molecular signature of the individual master regulators. Our anticipated results will provide deeper insight into fundamental NK cell biology. Importantly, our findings may lead to a more effective use of NK cells in cancer immunotherapy by providing valuable new clues towards the requirements of NK cell activation in vivo.]]></summary_en></project><project>
<id>8415</id><title_hr><![CDATA[Stanična parabioza: uloga međustanične komunikacije u fenotipskoj supresiji]]></title_hr><title_en><![CDATA[Cellular parabiosis: the role of cell-to-cell communication in phenotypic suppression  ]]></title_en><user_id>25906</user_id><user_firstLast_name>Katarina Trajkovic</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-3504</code><acronim><![CDATA[Stanična parabioza]]></acronim><duration>01.01.2020 - 12.03.2024</duration><status>Završio</status><financ_value>132.657,77 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Mediteranski institut za istraživanje života, Split]]></institution_hr><institution_en><![CDATA[Mediterranean Institute for Life Sciences, Split]]></institution_en><team_members_id>26065, 5816, 25337, 27240, 863814, 865059, </team_members_id><team_members_names><![CDATA[Tatjana Paunesku Paunesku, Miroslav Radman, Lea Vidatić, Sara Trifunović , Jelena Budimir, Nikola Pavlović, ]]></team_members_names><keywords_hr><![CDATA[fenotipska supresija, stres, senescencija, starenje, stanična heterogenost, neurodegeneracija, radiation, mikrozraka, međustanična komunikacija]]></keywords_hr><keywords_en><![CDATA[phenotypic suppression, stress, senescence, aging, cell heterogeneity, neurodegeneration, radiation, microbeam, cell-cell communication]]></keywords_en><summary_hr><![CDATA[Zdravo starenje jedan je od najvećih društvenih izazova suvremenog društva i s medicinskog i ekonomskog stajališta. Utvrđivanje molekularnih mehanizama starenja s ciljem razvoja strategija za njegovo usporavanje područje je intenzivnog istraživanja. Glavni cilj ovdje predloženog projekta je rješavanje nedovoljno istraženog koncepta da komunikacija između stanica igra važnu ulogu u odgađanju nastanka bolesti povezanih sa starenjem. Cilj nam je jednoznačno demonstrirati i mehanistički opisati fenomen fenotipske supresije disfunkcije pojedinačnih stanica kroz komunikaciju sa zdravom subpopulacijom okolnih stanica. Taj process nazivamo staničnom parabiozom. U tu svrhu, subpopulacija stanica s različitim aberantnim fenotipovima će se uzgajati u monokulturama ili u ko-kulturi s intaktnim, zdravim stanicama, a njihovi fenotipovi u ova dva stanja će se analizirati I usporediti upotrebom fluorescentne mikroskopije i protočne citometrije. Aberantni fenotipovi bit će inicirani prije ko-kultiviranja i to oksidativnim i proteotoksičnim stresom, zračenjem koje oštećuje DNK, uzgajanjem stanica do senescencije ili genskim mutacijama tipičnim za Niemann Pick neurodegeneraciju tipa C, kao i tretiranjem stanica koje su već u ko-kulturi vrlo prezicnim zračenjem pomoću X-ray mikrozrake. Očekujemo da ćemo otkriti poboljšanje aberantnih fenotipova u pogođenim stanicama koje rastu u ko-kulturama u usporedbi s onima koje se uzgajaju u monokulturama. Konačno, identificirat ćemo kojim mehanizmima stanice međusobno komuniciraju tijekom stanične parabioze ovisno o specifičnom izvoru oštećenja stanice. Jasna demonstracija i mehanistički opis središnje uloge stanične parabioze kao prirodnog zaštitnog principa otvorit će mogućnosti za razvoj inovativnih pristupa prevenciji višestrukih fenotipova povezanih sa starenjem usmjerenih na međustaničnu komunikaciju.]]></summary_hr><summary_en><![CDATA[Healthy aging is one of the most important goals of the contemporary society from the medical and economical perspectives. Thus, major research efforts are directed towards identifying molecular mechanisms of aging with the aim to develop strategies for attenuating aging. The main objective of our proposed project is to tackle promising, but insufficiently explored concept that cell-to-cell communication plays an important role in delaying onset of age-related diseases. We aim to unambiguously demonstrate and describe mechanistically the phenomenon of phenotypic suppression of individual cells&#39; dysfunction by the healthy subpopulation of surrounding cells, a process which we refer to as cellular parabiosis. To that end, a subpopulation of cells with various aberrant phenotypes will be grown in monocultures or in co-cultures with intact, healthy cells, and their phenotypes under these two conditions will be assessed and compared using fluorescent microscopy and flow cytometry. Aberrant phenotypes will be initiated before co-culturing by oxidative and proteotoxic stress, DNA-damaging radiation, by allowing cells to reach senescence or by genetic mutations underlying Niemann Pick type C neurodegeneration. Furthermore, DNA damage will be triggered directly in preexisting co-cultures using X-ray microbeam. We expect to detect amelioration of aberrant phenotypes in affected cells grown in co-cultures as compared to those grown in monocultures. Finally, we will identify cell-to-cell communication tools mediating cellular parabiosis in relation to specific aberrations. Clear demonstration and mechanistical description of the central role of cellular parabiosis as a natural protective principle will open possibilities for development of an innovative approach to prevention of multiple age-related phenotypes targeting cell-to-cell communication. ]]></summary_en></project><project>
<id>8418</id><title_hr><![CDATA[Računalno projektiranje nanotranzistora temeljenih na novim 2D materijalima]]></title_hr><title_en><![CDATA[Computational design of nanotransistors based on novel 2D materials]]></title_en><user_id>7054</user_id><user_firstLast_name>Mirko Poljak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2019-04</proposal_call><code>UIP-2019-04-3493</code><acronim><![CDATA[CONAN2D]]></acronim><duration>01.02.2020 - 30.06.2025</duration><status>Završio</status><financ_value>151.057,14 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>856199, 866807, 866787, </team_members_id><team_members_names><![CDATA[Mislav Matić, Tomo Vukadin Vukadin, Josip Jaram, ]]></team_members_names><keywords_hr><![CDATA[računska nanoelektronika, tranzistori, 2D materijali, skaliranje, atomistička simulacija, kvantni transport, NEGF, DFT]]></keywords_hr><keywords_en><![CDATA[computational nanoelectronics, transistors, 2D materials, scaling, atomistic simulation, quantum transport, NEGF, DFT]]></keywords_en><summary_hr><![CDATA[Predloženi projekt će istražiti karakteristike nanotranzistora temeljenih na novim dvodimenzionalnim materijalima otkrivenim nakon grafena, s fokusom na bizmuten. Istraživačka grupa će razviti napredni računalni program za atomističke simulacije i predviđanje performansi ovih nanotranzistora. Razvijeni program će spariti dvije napredne metode: ab initio teoriju funkcionala gustoće (DFT) i kvantni transport temeljen na formalizmu Greenove funkcije izvan termodinamičke ravnoteže (NEGF). DFT daje točnu strukturu energijskih pojaseva materijala s atomističkom rezolucijom, dok NEGF inherentno uključuje kvantnomehaničke efekte koji su prisutni u ekstremno skaliranim tranzistorima. Simulator ćemo implementirati na hibridnoj CPU-GPU platformi s paraleliziranim izvršenjem programskog koda da bi se omogućile simulacije na računalnom grozdu i na sveučilišnom superračunalu. Razvijeni alat će biti korišten za istraživanje utjecaja geometrije, dimenzija, materijala u stogu upravljačke elektrode i kristalnih defekata na karakteristike tranzistora. Provest će se projektiranje, istražiti mogućnosti optimizacije performansi i analizirati varijabilnost karakteristika uzrokovanu defektima. Ishodi istraživanja će odgovoriti na pitanje jesu li odabrani materijali ostvarive i uvjerljive alternative klasičnom volumnom siliciju i drugim 2D materijalima za sljedeće generacije poluvodičke tranzistorske tehnologije. Ovaj projekt će pružiti čvrstu osnovu za utemeljenje nove istraživačke grupe u području računske nanoelektronike. Uz programski paket, tehničku dokumentaciju, znanstvene publikacije i druge mjerljive rezultate, novoformirana grupa će doprinijeti izobrazbi hrvatskih studenata i istraživača što će unaprijediti njihove istraživačke i inovacijske kapacitete. Mreža potencijalnih suradnika, znanje i vještine koje će se steći za trajanja ovog projekta omogućit će buduće projektne prijave i osigurati snažan i održiv razvoj istraživačke grupe.]]></summary_hr><summary_en><![CDATA[The proposed project will explore the properties of nanoscale transistors implemented with novel two-dimensional materials beyond graphene, with a focus on bismuthene. Atomistic-level simulation software will be developed to simulate and predict the performance of these nanotransistors. The program will couple two state-of-the-art methods: ab initio density functional theory (DFT) and quantum transport based on non-equilibrium Green&#39;s function (NEGF) formalism. The DFT provides an accurate bandstructure with atomic resolution, while NEGF inherently covers quantum-mechanical effects present in extremely-scaled transistors. We will implement the simulator in a hybrid CPU-GPU platform with parallelized code execution in order to allow simulations on the computer cluster and university supercomputing facility. The simulation software will be employed to investigate the impact of device geometry, dimensions, gate stack materials and crystal defects on transistor characteristics. The results of this project will guide device design, explore possibilities for performance optimization, and assess device variability caused by defects. The outcomes of the research will answer the question of whether selected materials present feasible alternatives to bulk silicon and other contending 2D materials for next-generation transistor technologies. The project will provide a strong foundation for the establishment of an independent research group in the field of computational nanoelectronics. In addition to software, technical documentation, scientific publications and other project deliverables, the group will contribute to training of Croatian students and researchers, thus increasing their research and innovation capacities. Network of potential collaborators, knowledge, and expertise acquired during this project will facilitate future grant submissions that will ensure a strong and sustainable development of the research group.]]></summary_en></project><project>
<id>8421</id><title_hr><![CDATA[Antibiotička rezistencija u uređajima za obradu otpadnih voda u Hrvatskoj: naglasak na ß-laktamaze proširenog spektra i karbapenemaze]]></title_hr><title_en><![CDATA[Antibiotic Resistance in Wastewater Treatment Plants in Croatia: Focus on Extended-Spectrum ß-Lactamases and Carbapenemases]]></title_en><user_id>12566</user_id><user_firstLast_name>Nikolina Udiković Kolić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-5539</code><acronim><![CDATA[WasteCare]]></acronim><duration>01.01.2020 - 31.05.2024</duration><status>Završio</status><financ_value>164.383,83 eur</financ_value><scie_area_hr>Biotehničke znanosti, Prirodne znanosti, </scie_area_hr><scie_area_en>Biotechnical sciences, Natural sciences, </scie_area_en><scie_field_hr>Biotehnologija, Biologija, Interdisciplinarne prirodne znanosti, </scie_field_hr><scie_field_en>Biotechnology, Biology, Interdisciplinary natural sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>5324, 1305, 2653, 4621, 5731, 4001, 25998, 12589, 26296, 26274, 857304, </team_members_id><team_members_names><![CDATA[Ines Sviličić Petrić, Ivana Babić, Stela Križanović, Ana Šimatović, Ana Maravić, Marko Jelić, Josipa Kosic-Vuksic, Tamara Jurina, Gisle Vestergaard, Marko Virta, Ana Puljko, ]]></team_members_names><keywords_hr><![CDATA[antibiotička rezistencija, obrada otpadnih voda, karbapenemaze, ESBL, koliformne bakterije]]></keywords_hr><keywords_en><![CDATA[antibiotic resistance, wastewater treatment, carbapenemases, ESBLs, coliforms]]></keywords_en><summary_hr><![CDATA[Budući da rezistencija bakterija na antibiotike (AR) predstavlja značajnu prijetnju globalnom zdravlju, jedan od ciljeva Svjetske zdravstvene organizacije je integrirani nadzor AR u svim sektorima, uključujući i okoliš. U gradskim sredinama najvažniji rezervoari AR su postrojenja za obradu otpadnih voda (POV-a). Kroz interdisciplinarni pristup, projekt WasteCare je osmišljen da procjeni ulogu POV-a u širenju bakterija i gena koji ispoljavaju rezistenciju na kritično važne antibiotike u humanoj medicini, cefalosporine III. generacije i karbapeneme. Primijenit ćemo kvantitativni PCR za procjenu prevalencije gena za ß-laktamaze proširenog spektra (ESBL) i karbapenemaze te odabranih patogena kao potencijalnih nositelja tih gena u otpadnim vodama iz različitih POV-a u RH tijekom dvije sezone. Istodobno ćemo procijeniti prevalenciju E. coli i drugih koliformnih bakterija koje proizvode ESBL i karbapenemaze uzgojem na selektivnim podlogama. To će nam omogućiti procjenu lokalnih trendova AR u POV-a i njihovu sposobnost uklanjanja ciljnih gena i bakterija. Ovakav kvantitativni pristup bit će osnova za daljnje epicPCR analize kojima ćemo identificirati bakterije koje posjeduju gene za karbapenemaze u POV-a. To će, u kombinaciji sa izolacijom i fenotipskom te molekularnom karakterizacijom izoliranih enterobakterija, biti ključno za razumijevanje glavnih bakterijskih vrsta odgovornih za širenje AR putem otpadnih voda. U konačnici, prijenos plazmida koji proizvode ESBL i karbapenemaze direktno iz bakterija otpadnih voda u E. coli kao recipijent i njihovo kompletno sekvenciranje, bit će ključno za donošenje zaključaka o mogućoj razmjeni AR od najvećeg kliničkog prioriteta između okolišnih i bolničkih rezervoara. Vjerujemo da će dobivena saznanja imati vitalne implikacije na razvoj učinkovitih strategija upravljanja otpadnim vodama kako bi se smanjilo širenje AR preko okolišnih puteva.]]></summary_hr><summary_en><![CDATA[Integrated antibiotic resistance surveillance is one of the objectives of the World Health Organization global action plan on antibiotic resistance (AR), one of the biggest threats to global health today. Wastewater treatment plants (WWTPs) are among the most important reservoirs of AR in urban environments. With a holistic, interdisciplinary approach, the WasteCare is designed to assess the role of WWTPs in spreading of antibiotic resistant bacteria (ARB) and antibiotic resistance genes (ARGs) which are of highest concern in clinical settings. We will apply quantitative PCR (qPCR) to assess the prevalence of extended-spectrum ß-lactamase (ESBL) and carbapenemase genes as well as selected pathogens as relevant carriers of these genes in wastewaters from geographically dispersed WWTPs in Croatia over two seasons. As a complement to qPCR, the prevalence of ESBL- and carbapenemase-producing E. coli and other coliforms will be assessed by culturing. This will enable us to assess local AR trends in WWTPs and their ability to remove target ARGs and pathogens. The generated survey will lay the groundwork for epicPCR analyses to identify bacterial hosts of carbapenemase gene(s) in WWTPs. This, in combination with the isolation and characterization of enterobacterial isolates by phenotypic and molecular methods, will be crucial in understanding which species may be of major relevance for the spread of target AR via wastewaters. Finally, direct capturing of ESBL- and carbapenemase-producing plasmids from wastewater bacteria to E. coli as a recipient and their complete sequencing will be critical in drawing conclusions about the potential for exchange of AR of special clinical concern between environmental and clinical settings. We believe that this knowledge will have vital implications for the development of effective policy and wastewater management strategies to reduce the risk of hazardous ARB and ARGs being disseminated into the environment and thence back to humans.]]></summary_en></project><project>
<id>8430</id><title_hr><![CDATA[Antibakterijska prevlaka za biorazgradive medicinske materijale]]></title_hr><title_en><![CDATA[Antibacterial coating for biodegradable medicine materials]]></title_en><user_id>158</user_id><user_firstLast_name>Iva Rezić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-1381</code><acronim><![CDATA[ABBAMEDICA]]></acronim><duration>20.12.2019 - 19.06.2024</duration><status>Završio</status><financ_value>126.385,56 eur</financ_value><scie_area_hr>Tehničke znanosti, Biomedicina i zdravstvo, Prirodne znanosti, </scie_area_hr><scie_area_en>Technological sciences, Biomedicine and health sciences, Natural sciences, </scie_area_en><scie_field_hr>Interdisciplinarne tehničke znanosti, Kemija, Kemijsko inženjerstvo, Tekstilna tehnologija, Javno zdravstvo i zdravstvena zaštita, Farmacija, </scie_field_hr><scie_field_en>Interdisciplinary technological sciences, Chemistry, Chemical engineering, Textile technology, Public health and health services, Pharmaceutical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Tekstilno-tehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Textile Technology]]></institution_en><team_members_id>2958, 4302, 22624, 1048, 2762, 26359, 736, 26464, 864845, </team_members_id><team_members_names><![CDATA[Maja Somogyi Škoc, Slavica Bogović, Lela Pintarić, Roland Ludwig, Josip Barišić, Vanja Ljoljić Bilić, Marko Vinceković, Pierre-Alexis Mouthuy, Mislav Majdak, ]]></team_members_names><keywords_hr><![CDATA[kemija materijala, nanočestice, sol-gel modifikacija, antimikrobna zaštita, tanke prevlake, optimiranje]]></keywords_hr><keywords_en><![CDATA[materials chemistry, nanoparticles, sol gel modification, antimicrobial protection, thin coating, optimisation]]></keywords_en><summary_hr><![CDATA[Do 2050. godine od infekcija koje uzrokuju bakterije otporne na antibiotike moglo bi umrijeti više ljudi nego od AIDSa, tuberkuloze i virusnog hepatitisa zajedno. Samo u Europi 25000 smrtnih ishoda godišnje i troškovi > 1.5 milijarde eura posljedica su rezistentnih mikroorganizama. U ovom će projektu stoga biti razvijeni novi biorazgradivi medicinski materijali s antimikrobno aktivnom prevlakom učinkovitom protiv infekcija sojevima Staphylococcus Aureus na koje ne djeluju antibiotici (MSSA, MRSA). Time će se odgovoriti na zahtjeve Svjetske zdravstvene organizacije koja je ovaj problem istaknula kao glavni problem globalnom javnom zdravlju. Istraživanja će obuhvatiti razvoj antimikrobne prevlake za: i) vodoodbojnu posteljinu, ii) jednokratne antimikrobne obloge te iii) antimikrobne biorazgradive katetere. U razvoju antimikrobne formulacije primijeniti ćemo “beyond-state-of-the-art“ QSAR metode predviđanja djelovanja smjesa nanočestica s drugim biološki aktivnim tvarima pomoću metode odzivnih površina unutar računalnog programa dizajna eksperimenta. Tako proračunate antimikrobne smjese upotrijebiti će se za funkcionalizaciju površine biorazgradivih polimera kombinacijom sol-gel postupka, mikrokapsuliranja, elektroispredanja i 3D-tiska. Nove medicinske polimere karakterizirati ćemo spektroskopskim (LA-ICP-MS/MS, HPLCMS/MS Q-TOF te GC-MS/MS Q-TOF, NTA, UVVIS, ICPOES, GFAAS), kromatografskim (GC, TLC) i mikroskopskim (SEMEDX, TEM) metodama. Nakon modifikacije polimera, ispitat će se njihova nova funkcionalna svojstva (vodoodbojnost, antimikrobnost, postojanost, zeta potencijal). Provedba projekta pomoći će osnaživanju međunarodne interdisciplinarne istraživačke grupe i povećati istraživački potencijal ustanove nabavom nove opreme. Planira se prijava patenta čime će biti podržan razvoj farmaceutske i tekstilne industrije. Transferom znanja među europskih sveučilišta (Zagreba, Oxforda, Beča) poduprijeti će se integracija hrvatskih znanstvenika u europski istraživački okvir]]></summary_hr><summary_en><![CDATA[By the year 2050, more people will dye from infections caused by antibiotic-resistant bacteria than from AIDS, tuberculosis and viral hepatitis together. Only in Europe 25,000 deaths per year and costs over 1.5 billion euro are linked to the resistant microorganisms. Therefore in this project, new biodegradable medical materials with antimicrobial active coating will be developed against Staphylococcus Aureus MSSA and MRSA strains. This will address the priority demands of the World Health Organization, which has highlighted this problem as a major problem for the global public health. The research will include the development of antimicrobial coatings foreseen as: i) bedding materials, ii) wound coatings, and iii) biodegradable catheters. In the development of antimicrobial formulations, we will apply the &#39;&#39;beyond-state-of-the-art&#39;&#39; QSAR methods for prediction of antimicrobial properties of nanoparticles with other biologically active substances by response surface methodod and Design of Experiment. Optimized mixtures will be used for functionalization of biodegradable polymers by a combination of sol-gel process, microcapsulation, electrospinning and 3D printing. New polymers will be characterized by spectroscopic (LA-ICP-MS/MS, HPLCMS/MS Q-TOF, GC-MS/MS Q-TOF, NTA, UV-VIS, ICP-OES, GF-AAS), chromatographic (GC, TLC) and microscopic (SEM-EDX, TEM) techniques. After the modification of polymers, their new functional properties will be examined (water-resistance, antimicrobial, stability, zeta potential). The implementation of the project will strengthen the international interdisciplinary research group and increase the research potential of the institution by purchasing new equipment. A patent application is planned to support the development of the pharmaceutical and textile industries. Moreover, knowledge transfer between European universities (Zagreb, Oxford and Vienna) will support the integration of Croatian scientists into the European research framework.]]></summary_en></project><project>
<id>8432</id><title_hr><![CDATA[Aktivno sudjelovanje skupine kućanstava u energetskim tržištima]]></title_hr><title_en><![CDATA[Active NeIghborhoods energy Markets pArTicipatION]]></title_en><user_id>7162</user_id><user_firstLast_name>Hrvoje Pandžić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-9164</code><acronim><![CDATA[ANIMATION]]></acronim><duration>01.01.2020 - 31.12.2023</duration><status>Završio</status><financ_value>179.361,60 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>20517, 26067, 25844, 22498, 13621, 6990, 20291, 25372, 23193, 6996, 26129, 7194, 20181, 855435, 856080, 865151, 865100, 855441, </team_members_id><team_members_names><![CDATA[Lin Herencic, Sara Raos, Karlo Šepetanc, Ivan Rajšl, Ivan Pavić, Zeljko Tomsic, Hrvoje Bašić, Marija Miletić, Mirna Gržanić, Marko Delimar, Ivan Sudić, Matija Zidar, Vedran Bobanac, Ivan Grcić, Nikolina Čović, VIVEK PRAKASH, Marija Čuljak, Domagoj Badanjak, ]]></team_members_names><keywords_hr><![CDATA[aktivni potrošači, energetska tržišta, napredna kućanstva, optimizacija, razvoj softvera, laboratorijsko testiranje]]></keywords_hr><keywords_en><![CDATA[active consumers, energy markets, smart homes, optimization, software development, laboratory testing]]></keywords_en><summary_hr><![CDATA[Odziv potrošnje odnosi se na sposobnost potrošača električne energije da mijenja svoju krivulju potrošnje u cilju pružanja fleksibilnosti operatoru sustava, energetskom tržištu ili drugim korisnicima sustava. Velika većina današnjih pružatelja odziva potrošnje pripada skupini industrijskih ili komercijalnih pružatelja odziva potrošnje, dok su kućanstva rijetko uključena u programe odziva potrošnje. Predloženi istraživački projekt planira probuditi tržište odziva potrošnje u kućanstvima te aktivirati njihovu fleksibilnost. Predloženo istraživanje premostit će jaz između vladinih ciljeva, modela znanstvene zajednice i komercijalnih proizvođača sustava oblikovanjem i testiranjem kompletnog kućanstva koje će istovremeno moći na agregirani način sudjelovati na svim energetskim tržištima. Model kućanstva i agregatora bit će isporučen kao novi softverski alat osmišljen kako bi olakšao uključivanje i razumijevanje usluge odziva potrošnje te pokazao profitabilnost i učinkovitost predloženog koncepta.Osnovna ideja projekta je izraditi matematičke modele i opremiti laboratorij stvarnim kućanskim pametnim uređajima, punionicom za električna vozila, stacionarnom baterijom i fotonaponskim sustavom. Ispitat će se mogućnosti nuđenja usluga odziva potrošnje ovakvih kućanstava i definirati optimalna strategija za njihovo grupno sudjelovanje na tržištima. Ishodi istraživanja potaknut će kućanstva da pristupe različitim tržištima i da se transformiraju u aktivne potrošače svjesne svoje potrošnje i svojih računa. Kućanstva ujedinjena u zajedničkom cilju smanjenja troškova bi priključila svoje uređaje na aplikaciju za aktivna susjedstva koja bi ih uskladila i nudila njihove agregirane ponude na tržištu.]]></summary_hr><summary_en><![CDATA[Demand response (DR) refers to the ability of electrical load to change its consumption pattern in order to provide flexibility to the power system operator, in electricity market or to other power system users. Almost all of the demand response provided today is either industrial or commercial, as residential sector is much more delicate and complex to design due to a huge number of distributed resources as well as impact on people’s everyday lives. This especially applies to simultaneous participation of households in various markets. The proposed research project plans to shake up the household DR market and activate the households. The proposed research will bridge the gap between the government goals, scientific community models, and commercial system manufacturers as it will design and test a complete household able to simultaneously participate in an aggregated manner in all markets. The household and the aggregation models will be delivered as new software tools designed to ease the residents’ involvement and understanding of DR and to demonstrate the profitability and effectiveness of the proposed concept.General idea of the proposed project is to mathematically model and physically design a real household equipped with smart and connected devices, rooftop solar panels, EV charging station and a stationary battery. We will test the technical possibilities for DR provision of such households and define optimal market participation strategy for a group of households. Research outputs are aiming to empower and encourage active households to approach different power markets and to transform into active households aware of their power consumption and power bills. The households united under the same goal of cost minimization should connect their appliances to active neighborhood application, which will consolidate them, and submit aggregated bids to different markets. ]]></summary_en></project><project>
<id>8438</id><title_hr><![CDATA[Uloga biflavonoida u biljkama:  Gingko biloba L. kao modelni sustav]]></title_hr><title_en><![CDATA[Biflavonoids role in plants: Gingko biloba L. as a model system]]></title_en><user_id>2689</user_id><user_firstLast_name>Dunja Šamec</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2019-04</proposal_call><code>UIP-2019-04-1018</code><acronim><![CDATA[GinkoBiFlav]]></acronim><duration>15.06.2021 - 14.06.2026</duration><status>U tijeku</status><financ_value>265.445,62 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, Kemija, </scie_field_hr><scie_field_en>Biology, Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište Sjever]]></institution_hr><institution_en><![CDATA[University North]]></institution_en><team_members_id>334, 25413, 865508, 869686, </team_members_id><team_members_names><![CDATA[Bojan Šarkanj, Erna Karalija, Iva Jurčević, Barbara Medvedec, ]]></team_members_names><keywords_hr><![CDATA[biflavonoidi,  Gingko biloba L., prirodni spojevi, biljke, specijalizirani metaboliti]]></keywords_hr><keywords_en><![CDATA[biflavonoids, Gingko biloba L., natural product, plants, specialized metabolites]]></keywords_en><summary_hr><![CDATA[Biljke proizvode strukturalno raznovrsne specijalizirane metabolite, koji su se razvili u različitim biljnim vrstama i predstavljaju prilagodbe specifičnim ekološkim situacijama. Jedna od slabije istraženih skupina specijaliziranih metabolita su flavonoidni dimeri poznati kao biflavonoidi, a sastoje se od dvije identične ili ne-identične flavonoidne jedinice. Oni pokazuju bolju bioaktivnost od svojih monomernih podjedinica i smatraju se potencijalnim lijekovima u farmaceutskoj industriji i potencijalnim antioksidansima i antimikoticima u prehrambenoj industriji. Međutim, ostaje nejasno zašto neke biljne vrste proizvode dimerne strukture flavonoida, pod kojim uvjetima, te koja je uloga biflavonida u rastu i razvoju biljaka. Nakon doktorskog studija i postdoktorskog usavršavanja i 3 godine međunarodnog istraživačkog iskustva, u okviru predloženog projekta, glavni podnositeljica planira uspostaviti istraživačku grupu koja će se baviti proučavanjem uloge biflavonida u biljkama koristeći Gingko biloba L. kao modelni sustav. U sklopu projekta steći će se nova saznanja o relaciji strukture biflavonoida i biološke aktivnosti, o ulozi biflavonoida u starenju lišća G. bilobe kao i o biosintetskom putu biflavonoida koristeći in vitro kulturu G. biloba. U istraživanjima će se koristiti moderne metode biljne metabolomike (HPLC-DAD-MS/MS) i transkriptomike (NGS). Razumijevanje uloge biflavonoida u biljkama doprinosi sveukupnom znanju o interakcijama biljaka i okoline i procesima koji reguliraju rast, razvoj i adaptaciju biljaka tolerantnih na okolišne promjene. ]]></summary_hr><summary_en><![CDATA[The plant kingdom produces an overwhelming array of structurally diverse specialized metabolites. One of the less studied group of specialized metabolites are flavonoid dimers known as a biflavonoids, consist of two identical or non-identical flavonoid units. They show superior bioactivity than their monomeric subunits and are considered to be potential drugs in the pharmaceutical industry and potential antioxidant and antimicrobial agent in the food industry. But, it remains unclear why some plant species produce dimeric structures of flavonoids, under which condition, and what is the role of biflavonoids in plant growth and development.  After doctoral study, postdoctoral training and 3 years of international research experience, within the project, the main applicant plan to establish research group focus on evaluation of biflavonoid role in plants using Gingko biloba L. as a model system. As a part of the project we will gain knowledge about structure-biological activity relation of biflavonoids present in G. biloba., about the role of biflavonoids in G. biloba leaves senescence and about biflavonoid biosynthetic pathway(s) using in vitro culture. In a research we will use modern techniques of plant metabolomic (HPLC-DAD-MS/MS) and transcriptomic (NGS). Understanding of biflavonoids role in plants contributes to the overall knowledge about plant-environment interactions and processes that regulate growth, development and adaptation of tolerant species to ever-changing environment]]></summary_en></project><project>
<id>8439</id><title_hr><![CDATA[Međudjelovanje morskog (mikro)plastičnog otpada i metala zagađivala: mogući put od morskog okoliša do čovjeka]]></title_hr><title_en><![CDATA[Marine (micro)plastic litter and pollutant metals interaction: a possible pathway from marine environment to human]]></title_en><user_id>120</user_id><user_firstLast_name>Vlado Cuculić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-5832</code><acronim><![CDATA[METALPATH]]></acronim><duration>05.02.2020 - 04.07.2024</duration><status>Završio</status><financ_value>130.579,34 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Interdisciplinarne prirodne znanosti, </scie_field_hr><scie_field_en>Interdisciplinary natural sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>12837, 4198, 80, 3321, 23289, 2829, 5780, 212, 13139, 865067, 19764, 20245, </team_members_id><team_members_names><![CDATA[Ana-Marija Cindrić, Neven Cukrov, Stanislav Frančišković-Bilinski, Jasminka Klanjšček, Željko Kwokal, Zrinka Ljubešić, Kristina Pikelj, Irina Pucić, Hana Fajković, Ana Rapljenović, Nuša Cukrov, Marko Viskić, ]]></team_members_names><keywords_hr><![CDATA[morski (mikro)plastični otpad, metali u tragovima, morski okoliš, istočno Jadransko more, sediment, morska voda]]></keywords_hr><keywords_en><![CDATA[marine (micro)plastic litter, trace metals, marine environment, Eastern Adriatic Sea, sediment, seawater]]></keywords_en><summary_hr><![CDATA[Projekt je usmjeren k istraživanju međudjelovanja morskog plastičnog otpada i metala u tragovima (MT), posebice prioritetnih zagađivala Hg, Cd, Pb i Cu u obalnim područjima. S godišnjom proizvodnjom od 350 megatona (u rastu), plastika je jedan od glavnih onečišćivača te ima dugo vrijeme raspada i zbog toga se koncentrira u morima, dok Jadran postaje jedno od najzagađenijih mora plastikom. Druga potencijalno opasna komponenta u moru su MT koji predstavljaju značajnu prijetnju ljudskom zdravlju i morskim organizmima. Međudjelovanje morskog plastičnog otpada i MT može rezultirati njihovom prekoncentracijom/akumulacijom te stoga postati prijetnja za različite ekosustave.Interdisciplinarna istraživanja temelje se na suradnji širokog spektra znanstvenika i stručnjaka iz područja oceanologije, analitičke kemije, kemije polimera, geologije, biologije te ekološkog modeliranja. Specifični ciljevi su: analiza svojstava polimera te mikroplastike iz morskog okoliša; istraživanje adsorpcije MT na mikroplastiku; ispitivanje raspodjele koncentracija MT u morskoj vodi, sedimentu, mikroplastici i u morskim organizmima kao mogućoj direktnoj i/ili indirektnoj prijetnji čovjeku te procesa koji kontroliraju biogeokemijsko kruženje MT među njima; istraživanje učinka organske tvari, kao i pojedinih zajednica morskih mikroorganizama (mikrobiom) iz sedimenta na međudjelovanje MT i mikroplastike. Koristit ćemo najnovije elektrokemijske i spektrometrijske tehnike. Dobivene rezultate ćemo upotrijebiti za razvijanje ekološkog modela međudjelovanja MT i mikroplastike, za predviđanje njihova utjecaja na obalne ekosustave i pronalaženje optimalnih metoda za smanjivanje te prijetnje.Specifični ciljevi su odabrani s motivom da krajnji rezultat projekta bude koristan ne samo široj znanstvenoj zajednici, nego i krajnjim korisnicima kao što su lokalna i državna tijela koja upravljaju obalnim područjima. Nova saznanja mogu biti temelj boljoj procjeni rizika u svrhu unaprjeđenja kakvoće okoliša.]]></summary_hr><summary_en><![CDATA[Project will study marine plastic litter and trace metals (TM) interaction, especially primary pollutants Hg, Cd, Pb and Cu in the coastal areas. With annual production of 350 megatons (and rising), plastics have been recognized as one of the main pollutants, long-living, slowly decomposing and accumulating in oceans, while Adriatic becomes one of the most polluted seas regarding plastic litter. Another hazardous component in ocean are TMs that pose a substantial threat for the human health and marine biota. Once TM interact with marine plastic litter, hence concentrate/accumulate, it could become threat for the various coastal ecosystems.Interdisciplinary research involves wide spectrum of scientists and experts in the fields of oceanology, analytical chemistry, polymer chemistry, geology, biology and ecological modelling. Specific objectives are: characteristics assessment of polymer, and microplastics from marine environment; studying TM adsorption on unused polymers and on environmental microplastics; analysing TM distribution in coastal waters, sediments, microplastics and marine organisms as a possible direct and/or indirect threat to human, as well as the processes that govern TM biogeochemical cycles among them; study the effects of organic matter as well as specific marine microorganism communities (microbiome) from sediment on TM interaction with microplastics. We will use the most recent approaches utilizing electrochemical and spectrometric techniques. Results will enable us to develop an ecological model of TM-microplastics interactions, to predict TM-microplastic impact on coastal ecosystems and to find optimal method in weakening its threat.The specific objectives are selected to enable the outcome of the project be valuable not only to the broad scientific community, but also to end-users such as authorities that manage coastal zones. New findings can be the basis for a better risk assessment in order to improve the environmental quality.]]></summary_en></project><project>
<id>8440</id><title_hr><![CDATA[Analiza strukturnih čimbenika konvergencije Republike Hrvatske tijekom tranzicijskog procesa]]></title_hr><title_en><![CDATA[Analysis of structural factors of convergence of Croatia during the transition process]]></title_en><user_id>4150</user_id><user_firstLast_name>Josip Tica</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-4500</code><acronim><![CDATA[CONVRH]]></acronim><duration>20.02.2020 - 12.07.2024</duration><status>Završio</status><financ_value>64.779,07 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, </scie_field_hr><scie_field_en>Economy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Ekonomski fakultet u Zagrebu]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Economics and Business]]></institution_en><team_members_id>3966, 503, 4626, 3874, 3747, 23759, 3635, 4139, 26378, 26461, 45, 865142, </team_members_id><team_members_names><![CDATA[Alka Obadić, Jurica Šimurina, Tomislav Gelo, Ana Andabaka, Vladimir Arčabić, Marko  Družić, Tomislav Globan, Nebojša Stojčić, Viktor Viljevac, Goran Buturac, MARTINA BASARAC SERTIĆ, Matija Matić, ]]></team_members_names><keywords_hr><![CDATA[Tranzicija, konvergencija, ekonomski rast, faktori rasta, strukturne promjene, sektorske promjene, inovacije, globalni lanci vrijednosti]]></keywords_hr><keywords_en><![CDATA[Transition, convergence, economic growth, growth factors, structural change, relative shares of sectors, innovations, global value change]]></keywords_en><summary_hr><![CDATA[Čitav niz dosadašnjih istraživanja ukazao je ispravnost empirijske činjenice kako je Hrvatska tijekom posljednjih 27, odnosno gotovo 40 godina relativno zaostala za okruženjem. S izuzetkom nekih općenitih ideološki obojenih kritika stanja i razvoja ekonomije, ekonomska istraživanja nisu otišla u smjeru otkrivanja ključnih uzroka navedene stagnacije odnosno relativnog ekonomskog zaostajanja. Cilj ovoga istraživanja je pronaći ključne čimbenike koji objašnjavaju ekonomske (ne)uspjehe tranzicijskih zemalja u kontekstu teorija rasta, strukturnih promjena, tržišta rada, tržišta kapitala i sektorske analize. Najvažniji ishodi navedenog istraživanja trebali bi ponuditi podlogu na kojoj bi se mogla povesti činjenično utemeljena rasprava o rješavanja nagomilanih razvojnih problema hrvatskog gospodarstva. Osnovni učinak istraživanja trebao bi biti rasvjetljavanje različitosti zabilježenih u razvojnom putu Hrvatske i ostalih tranzicijskih zemalja tijekom posljednjih 30 godina tranzicije, ispitivanje korelacije i kauzalne veze između specifičnosti hrvatskog razvojnog puta, makroekonomskih agregata i relativnog gospodarskog zaostajanja. Očekivani znanstveni rezultati istraživanja su objava do (ovisno o trajanju recenzije) 11 radova u znanstvenim časopisima citiranim u WoS ili Scopus bazama podataka. Objava jednog poglavlja u knjizi kod svjetski renomiranog izdavača. Prezentacija 4 rada na domaćim i 11 prezentacija rezultata istraživanja na relevantnim međunarodnim konferencijama. U metodološkom smislu fokusirati ćemo se na sofisticirane ekonometrijske metode (PVAR, prostorna ekonometrija, log-t-testovi  konvergencije, dinamički threshold panel modeli...) kako bi maksimalno povećali izglede za objavljivanje u gornjim kvartilima, te stoga planiramo organizaciju 2 ekonometrijske radionice renomiranih gostujućih profesora iz područja panel ekonometrije i ekonometrije vremenskih serija. U posljednjoj godini projekta planiramo završni skup i prezentaciju rezultata na skupu u HAZU-u. ]]></summary_hr><summary_en><![CDATA[A large number of studies have confirmed stylized fact about relative divergence of Croatia during the last 27-40 years vis-a-vis comparable transition countries. With the exception of several ideologically biased analyses of the causes of divergence, economic research did not provide any sound proofs or evidence about key factors of relative divergence and absolute economic stagnation in Croatia. The aim of this research is to identify key factors of convergence within the transition process in terms of economic growth, structural changes, labour market, stock market, and sector analysis. The key results of the research will provide fundamentals for an objective discussion and policy recommendation necessary to address development issues of the Croatian economy. The main impact of the research will be an identification of differences in the development in Croatia vis-a-vis  other post-transition countries during the last thirty years. We will focus on the correlation and causality between specific development patterns in Croatia with macroeconomic aggregates and relative economic divergence. Project’s expected results are publication and/or submission (depending on the review process) of up to eleven research papers in the journals indexed in the WoS or Scopus databases, publication of a chapter in a book published by an internationally recognized publisher. Four paper presentations at local conferences, and eleven paper presentations at international conferences. We plan to use sophisticated methodological approach (PVAR, dynamic threshold panel models, t-log tests of convergence, spatial econometrics...)  in order to increase our chances of publishing in upper quartiles. Therefore, we plan to organize two econometric workshops with international visiting scholars in the field of advanced panel data econometrics and time series econometrics.  Furthermore, in the last year we plan to organize a conference in the Croatian academy of sciences and arts (HAZU).]]></summary_en></project><project>
<id>8444</id><title_hr><![CDATA[Istraživanje fononski posredovanih procesa u kvazi-dvodimenzionalnim materijalima]]></title_hr><title_en><![CDATA[Study of phonon-assisted processes in quasi-two-dimensional materials]]></title_en><user_id>26143</user_id><user_firstLast_name>Dino Novko</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2019-04</proposal_call><code>UIP-2019-04-6869</code><acronim><![CDATA[SyPhonAss_Q2D]]></acronim><duration>15.01.2020 - 14.01.2025</duration><status>Završio</status><financ_value>198.686,04 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut za fiziku]]></institution_hr><institution_en><![CDATA[Institute of Physics in Zagreb]]></institution_en><team_members_id>26407, 855985, 867651, </team_members_id><team_members_names><![CDATA[Fabio Caruso, NINA GIROTTO, Ertugrul Karaca, ]]></team_members_names><keywords_hr><![CDATA[elektron-fonon vezanje, ultrabrza dinamika, Raman, optička apsorpcija, fotoemisija, 2D materijali, grafen, dihalkogenidi prijelaznih metala]]></keywords_hr><keywords_en><![CDATA[electron-phonon coupling, ultrafast dynamics, Raman, optical absorption, fotoemission, 2D materials, graphene, transition metal dichalcogenides]]></keywords_en><summary_hr><![CDATA[Glavni cilj ovog projekta je provesti temeljitu teorijsku studiju o ulozi elektron-fonona vezanje u novim kvazi-dvodimenzionalnim materijalima pomoću kvantitativnih metoda iz prvih principa. Utjecaj elektron-fonon interakcije na dinamiku fonona i elektrona planira se proučavati u ravnotežnim i neravnotežnim uvjetima, pri čemu su energije elektrona i stupnjeva slobode rešetke jednake, odnosno nejednake. Naime, namjeravamo istražiti grafenske materijale, metalne i poluvodičke verzije dihalkogenida prijelaznih metala, kao i neke nedavno otkrivene dvodimenzionalne materijale poput borofena. Svaki od ovih materijala posjeduje jedinstvene optičke osobine poželjne za primjene u optoelektronskoj industriji, koje su dobrim djelom određene upravo dinamičkim međudjelovanjem elektrona i fonona. Pripadni teorijski rezultati moći će se izravno povezati s nekoliko spektroskopskih tehnika, kao što su Raman, reflektivna i fotoemisijska mjerenja, te također s njihovim vremenski razlučivim verzijama, gdje se neravnotežni uvjeti postižu tzv. &#39;&#39;pump-probe&#39;&#39; metodama. To čini predloženu studiju potencijalno bitnu za nadopunjavanje te rasvjetljavanje spomenutih eksperimenata, ali i za predviđanje novih fizikalnih pojava koje će služiti kao temelj za budući eksperimentalni rad.]]></summary_hr><summary_en><![CDATA[The main goal of the present project is to conduct a thorough theoretical study on the role the electron-phonon coupling in novel quasi-two-dimensional materials by using quantitative first-principles methods. The impact of the electron-phonon interaction on phonon and electron dynamics is planned to be studied under both equilibrium and nonequilibrium conditions, where energies of electron and lattice degrees of freedom are equal and mismatched, respectively. Specifically, we intend to investigate graphene-related materials, metallic and semiconductive versions of transition metal dichalcogenides, as well as some recently discovered two-dimensional materials like borophene. Each of these materials possesses unique optical properties highly desirable for applications in optoelectronic industry, which are ruled in parts by dynamical interplay between electrons and phonons. The corresponding theoretical output will be directly related to several spectroscopic techniques, like Raman, reflectivity, and photoemission measurements, as well as to their time-resolved versions, where nonequilibrium condition is achieved through &#39;&#39;pump-probe&#39;&#39; methods. This renders the proposed study a potentially essential for complementing and elucidating the aforementioned experiments, but also for predicting novel physical features and thus encouraging future experimental work.]]></summary_en></project><project>
<id>8450</id><title_hr><![CDATA[Gensko, proteinsko i RNA profiliranje kolorektalnog karcinoma primjenom tekuće biopsije]]></title_hr><title_en><![CDATA[Genetic, Protein and RNA Profiling of Colorectal Cancer Using Liquid Biopsy]]></title_en><user_id>13795</user_id><user_firstLast_name>Karmela Barišić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-4624</code><acronim><![CDATA[CRCMolProfil]]></acronim><duration>01.03.2020 - 31.05.2024</duration><status>Završio</status><financ_value>132.590,09 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Farmacija, Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Pharmaceutical sciences, Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Farmaceutsko-biokemijski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Pharmacy and Biochemistry]]></institution_en><team_members_id>20390, 23488, 23489, 23498, 21314, 6467, 23648, 23718, 6134, 23671, 12546, 12345, 12721, 6927, 3520, 3517, 5552, 23928, 865528, 867591, </team_members_id><team_members_names><![CDATA[Mario Štefanović, Lara Batičić Pučar, Dijana Detel, Neven Ljubičić, Andrea Čeri, Ivana Rako, Roberta Petlevski, Alma Demirović, Ivana Ćelap, József  Petrik, Anita Somborac Bačura, Lada Rumora, Božo Krušlin, Neven Baršić, Andrea Hulina Tomašković, Marija Grdić Rajković, Donatella Verbanac, Snježana Ramić, Marija Fabijanec, Martha Koržinek, ]]></team_members_names><keywords_hr><![CDATA[tekuća biopsija, kolorektalni karcinom, biopokazatelji, cirkulirajuća tumorska DNA, eksosomi, cirkulirajuće tumorske stanice]]></keywords_hr><keywords_en><![CDATA[liquid biopsy, colorectal cancer, biomarkers, circulating tumor DNA, exosomes, circulating tumor cells]]></keywords_en><summary_hr><![CDATA[Tekuća biopsija neinvazivan je i ponovljiv postupak uzimanja periferne krvi iz koje se specifičnim metodama izoliraju cirkulirajuće tumorske stanice (CTC), vezikulne strukture podrijetlom iz tumorskih stanica, eksosomi te cirkulirajuća tumorska DNA (ctDNA). Cilj predloženog istraživanja jest identifikacija biopokazatelja specifičnih za kolorektalni karcinom (CRC) u biološkim uzorcima dobivenim tim neinvazivnim postupkom te procjena njihovog dijagnostičkog potencijala u usporedbi s uzorcima tkiva dobivenim tijekom kolonoskopije. Za biopokazatelje odabrani su oni geni, RNA i proteini koji su povezani s etiologijom CRC-a; promjenama signalnih putova, remodeliranjem izvanstaničnog matriksa, međustaničnom komunikacijom, povećanom vaskularnom permeabilnošću i upalom potaknutom tumorom. Istraživanje će obuhvatiti detekciju genskih varijanti sljedećih gena: KRAS, BRAF, NRAS, PIK3CA, TP53, and JAK2. Među RNA transkriptima bit će analizirane relevantne mikroRNA i ekspresija gena c-MYC.  Proteinska analiza obuhvatit će proteine za koje postoji dokazana povezanost s CRC. Predloženi projekt uključit će 60 pacijenata s CRC-om i 200 pacijenata s adenomom (pre-CRC, referentna skupina).  Genski profili za CRC i pre-CRC bit će generirani iz podataka o genskim varijantama prisutnim u tkivu i ctDNA. RNA profil odnosit će se na podatke o prethodno navedenim RNA transkriptima prisutnim u tkivu i eksosomima. Proteinski profil bit će generiran iz podataka o koncentraciji CEA i CA 19-9 u serumu te DPP IV, MMP9, Hsp60, Hsp70, kadherin17 i TGF-beta u tkivu i eksosomima. Kao rezultat ispitivanja očekuje se utemeljena procjena dijagnostičkog potencijala svakog odabranog biopokazatelja za CRC koji se može analizirati u biološkim uzorcima dobivenim postupkom tekuće biopsije i da odabrani geni i njihove varijante, RNA transkripti i proteini prisutni u ctDNA i eksosomima jednoznačno zrcale molekulska događanja u tumorskom tkivu.  ]]></summary_hr><summary_en><![CDATA[Liquid biopsy is a non-invasive and repeatable procedure that involves sampling peripheral blood for isolation of circulating tumour cells (CTC), vesicular structures exosomes that are released into the circulation by tumour cells, and circulating tumour DNA (ctDNA). The general objective of this project is to identify biomarkers specific for colorectal cancer (CRC) in biological samples obtained with liquid biopsy and to evaluate their diagnostic potential. The project will include the detection of genetic variants of the following genes:  KRAS, BRAF, NRAS, PIK3CA, TP53, and JAK2. Among the RNA transcripts, we shall analyze the relevant microRNAs and the expression of the c-MYC gene. Protein analysis will include protein biomarkers with proven association with aetiology of CRC.  The project needs to include 60 CRC-subjects and 200 pre-CRC subjects (referent group), in accordance with the estimation of the study&#39;s strength, and taking into account the adenomas variability. Genetic profiles for CRC and pre-CRC will be generated based on the data describing genetic variants present in tissue and ctDNA. RNA profile refers to the transcripts present in tissue and exosomes. Protein profile will be generated based on data about serum concentrations of CEA, CA-19-9 and the expression of DPP IV, MMP9 Hsp60, Hsp60, Hsp70, cadherin17, TGF-beta in tissue and exosomes. The proposed project is expected to identify reliable diagnostic biomarkers for CRC that can be analysed in biological samples derived from peripheral blood using liquid biopsy. We expect to confirm the thesis that selected genes and their variants, transcripts and proteins, present in ctDNA and exosomes, accurately reflect the molecular events in the tumour tissue.]]></summary_en></project><project>
<id>8451</id><title_hr><![CDATA[Stohastičke aproksimacije malog ranga i primjene na parametarski ovisne probleme]]></title_hr><title_en><![CDATA[Randomized low rank algorithms and applications to parameter dependent problems]]></title_en><user_id>4557</user_id><user_firstLast_name>Luka Grubišić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-6268</code><acronim><![CDATA[RandLRAP]]></acronim><duration>15.01.2020 - 30.03.2024</duration><status>Završio</status><financ_value>85.149,64 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>2945, 5056, 4757, 17823, 25925, 26510, 25877, 26820, 26467, 865505, </team_members_id><team_members_names><![CDATA[Zlatko Drmač, Zvonimir Bujanović, Nela Bosner, Ivana Šain Glibić, Lana Periša, Daniel Kressner, Serkan Gugercin, Jeffrey Ovall, Harri Hakula, Domagoj Lacmanović, ]]></team_members_names><keywords_hr><![CDATA[aproksimacije malog ranga, diskretna empirijska interpolacija, algoritmi s probirom, multiparametarski problem vlastitih vrijednosti, konačni elementi]]></keywords_hr><keywords_en><![CDATA[low rank approximations, discrete empirical interpolation, sampling algorithms, multiparameter eigenvalue problems, finite elements, Lyapunov equation]]></keywords_en><summary_hr><![CDATA[Tehnike aproksimacije multilinearnim formama niskog ranga okosnica su mnogih modernih aplikacija koje se temelje na podacima. Takve aplikacije koriste se od analize sigurnosti i robusnosti inženjerskih problema, preko testiranja stabilnosti u financijskim aplikacijama do općih pitanja znanosti o podacima u primjenama od društvenog značaja. Proučavat ćemo teorijske i praktične aspekte ovog problema. Kao prototipove razmatrat ćemo dinamičke sustave u prisutnosti nesigurnosti. Vrijednosti od interesa su srednja vrijednost, varijanca i vjerojatnost prekoračenja za polje rješenja. Glavni izazov u proučavanju tih problema je pobijediti tzv. prokletstvo dimenzionalnosti (eksponencijalno povećanje računalnog napora s povećanjem broja parametara koji se uzorkuju). Usredotočit ćemo se na familiju problema za parcijalne diferencijalne jednadžbe ovisne o parametrima te ćemo razviti i analizirati robusne i učinkovite numeričke metode za njihovo rješavanje. Temeljna računska zadaća je numerička analiza rezolvente problema. Glavni alati koje koristimo je uzorkovanje u prostoru slike matrice, koje se temelji na maxvol algoritmu, i metode redukcije dimenzije modela aproksimacijom formom malog ranga. Ovaj projekt ćemo iskoristiti i za postavljanje temelja za razvoj istraživačke skupine u Hrvatskoj koja će se baviti matematičkim aspektima znanosti o podacima. Kao temelj iskoristiti naše iskustvo u numeričkoj linearnoj algebri i numeričkoj teoriji operatora u kontekstu proučavanja višeskalnih problema svojstvenih vrijednosti s primjenama na termo akustici i fotoničkim kristalima.]]></summary_hr><summary_en><![CDATA[Low rank approximation techniques are the backbone of many modern data driven applications. Such applications have utilization ranging from the analysis of the safety and robustness of engineering problems, over stress testing in financial applications to general big data questions in applications of societal relevance.  We will study both the theoretical as well as practical aspects of this problem. As prototypes we will consider dynamical systems in the presence of uncertainty. The quantities of interest are the mean, the variance and the exceedance probability for the solution field. The main challenge in the study of these problems is to beat the so-called curse of the dimensionalty (exponential increase in computing effort with the increase of the number of uncertain parameters). We will concentrate on the family of parameter dependent partial differential equations and we will develop and analyze robust and efficient numerical methods to tackle them. We will also study the modal problem and the frequency response problem, which are used to analyze dynamical systems. Both problems have a core computational task which is the computational analysis of the resolvent function. These problems fall into the category of modern data driven applications, even though we sample the system by simulation and not measurement. Main tools which we employ are randomized sampling in the image space of a matrix loosely based on maxvol algorithm and its variants and model order reduction by low rank compression. We also aim to use this project to lay foundation for a research group in Croatia which will study mathematical foundations of data driven applications (including those that fall into the area of machine learning). In the first instance, we will leverage our experience in numerical linear algebra and computational operator theory in the context of the study of multi parameter eigenvalue problems in thermoacustics and photonics. ]]></summary_en></project><project>
<id>8452</id><title_hr><![CDATA[Biomedicinsko oslikavanje karcinoma dojke]]></title_hr><title_en><![CDATA[Biomedical imaging of breast carcinoma]]></title_en><user_id>12520</user_id><user_firstLast_name>Maja Prutki</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-3684</code><acronim><![CDATA[BOBCAt]]></acronim><duration>07.01.2020 - 06.01.2024</duration><status>Završio</status><financ_value>81.146,73 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Kliničke medicinske znanosti, Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Clinical sciences, Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>26764, 25943, 26771, 26782, 25950, 26796, 26805, 26811, 24121, 17841, 26767, 22619, 12474, 862788, </team_members_id><team_members_names><![CDATA[Lucija Kovačević, Elvira Kresic, Paula Podolski, Ivan  Bilić, Ana Marija Alduk, Lea Korsa, Zlatko Marušić, Natalija Dedić Plavetić, Tomislav Lipić, Andrija Štajduhar, Sanja Baršić Ostojić, Anto Dujmović, Stjepko Pleština, Karlo Stemberger, ]]></team_members_names><keywords_hr><![CDATA[Radiomika, Veliki podatci, MR dojke, Oslikavanje dojke, Karcinom dojke, Biomarker, CaSR]]></keywords_hr><keywords_en><![CDATA[Radiomics, Big data, Breast MRI, Breast Imaging, Breast cancer, Biomarker, CaSR]]></keywords_en><summary_hr><![CDATA[Biomedicinsko oslikavanje omogućava vizualni prikaz unutarnjih organa te se smatra obećavajućom strategijom u dijagnostici. Radiomika, veza između slikovnih metoda i personalizirane medicine, analizira različite radiomske značajke ekstrakcijom velikih količina kvantitativnih značajki slike. Karcinom dojke (BC), heterogena bolest koja dolazi u nekoliko histoloških podtipova koji se razlikuju u kliničkoj slici i terapijskom odgovoru, je najčešći karcinom u žena.  Rezistencija na sistemsku terapiju je uobičajena, a rana detekcija iste krucijalna je za optimalno liječenje tih bolesnika. Neoadjuvantna terapija (NAT), preoperativna sistemska terapija, provodi se sa svrhom smanjenja opsega kirurškog zahvata.  Radiološka dijagnostika ima važnu ulogu u praćenju uspjeha NAT i ranom otkrivanju potencijalne progresije bolesti tijekom NAT. Procjena fenotipa primarnog tumora i metastaza je od velike važnosti za određivanje mogućnosti liječenja. Budući da je uzimanje uzastopnih biopsija iz udaljenih metastaza često otežano, radiomika kao neinvazivna metoda ima veliki potencijal u detekciji fenotipova otpornih na terapiju. Ova studija će procijeniti prediktivni potencijal radiomskih fenotipova ekstrahiranih iz  dinamičke magnetne rezonance (DCE-MRI) pri određivanju podtipova BC, stadija bolesti i procjeni dugoročnih ishoda. Evaluirat će se radiomski fenotipovi primarnog BC i udaljenih metastaza temeljeni na DCE-MRI snimkama. Analizirat ćemo promjene radiomskih značajki ekstrahiranih iz multiparametrijske magnetske rezonance (mp-MRI) prije i nakon dva ciklusa NAT, kao i potencijal istih u procjeni potpunog patološkog odgovora. Evaluirat će se prediktivna vrijednost razine ekspresije receptora osjetljivog na kalcij (CaSR) za razlikovanje koštanih i visceralnih metastaza kao i povezanost kolina i pojavnog difuzijskog koeficijenta iz analize mp-MRI s izražajem CaSR.]]></summary_hr><summary_en><![CDATA[Biomedical imaging provides a visual representation of the inner body and is considered a promising diagnostic strategy. Radiomics, a link between medical imaging and personalized medicine, analyses phenotypic gene expression through high throughput extraction of large amounts of quantitative image features. Breast cancer (BC), the most common cancer among women, is a highly heterogeneous disease that comes in several histological subtypes which differ in clinical presentations and therapy response. Systemic therapy resistance is common, making early recognition essential for the optimal management of these patients. Neoadjuvant Therapy (NAT) or preoperative systemic therapy, if effective, may allow for less extensive surgery. Imaging has a pivotal role in monitoring NAT success and early detection of potential disease progression during NAT. Assessment of primary tumor and metastasis phenotypes is essential for determining treatment options. Since consecutive biopsies from distant metastases are often difficult, it is necessary to find a more accessible approach to detect therapy resistant phenotype. Radiomics represents a new promising personalized approach. This study will evaluate the predictive potential of radiomic phenotypes extracted from dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) for determination of BC subtypes, stage of the disease, and long term outcomes. DCE-MRI image-based phenotypes of primary BC and distant metastases will be analyzed. Changes in textural features extracted from multiparametric magnetic resonance imaging (mp-MRI) before and after two cycles of NAT and the potential value of radiomic features in assessment of pathologic complete response will be examined. Predictive value of calcium-sensing receptor (CaSR) expression level for the distinction of skeletal vs. visceral metastases as well as the correlation of choline peak and apparent diffusion coefficient at mp-MRI with CaSR expression level will be assessed.]]></summary_en></project><project>
<id>8460</id><title_hr><![CDATA[Modeli odgovora na odgojno-obrazovne potrebe djece izložene riziku socijalne isključenosti u ustanovama ranog i predškolskog odgoja i obrazovanja]]></title_hr><title_en><![CDATA[Models of Response to Educational Needs of Children at Risk of Social Exclusion in Early and Childhood Education and Care Institutions]]></title_en><user_id>7722</user_id><user_firstLast_name>Dejana Bouillet</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-2011</code><acronim><![CDATA[MORENEC]]></acronim><duration>15.01.2020 - 14.05.2024</duration><status>Završio</status><financ_value>75.283,96 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Pedagogija, Psihologija, Edukacijsko-rehabilitacijske znanosti, </scie_field_hr><scie_field_en>Pedagogy, Psychology, Physical education and rehabilitation sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>7651, 25839, 23515, 12398, 22610, 23832, 25882, 13059, </team_members_id><team_members_names><![CDATA[Vlatka Domović, Adrijana Višnjić Jevtić, Ivana Visković, Esmeralda Sunko, Sanja  Skočić Mihić, Sandra Antulić Majcen, MAJA DRVODELIĆ , Monika Pažur, ]]></team_members_names><keywords_hr><![CDATA[rani i predškolski odgoj i obrazovanje, rizik socijalne isključenosti, etiološki i fenomenološki aspekti rizika, mjere potpore, evaluacija]]></keywords_hr><keywords_en><![CDATA[Early and Childhood Education and Care, Risk of Social Exclusion, Etiological and Phenomenological Aspects of Risks, measures of Support, Evaluation]]></keywords_en><summary_hr><![CDATA[Kumulativni činitelji rizika socijalne isključenosti se višestruko nepovoljno odražavaju na kvalitetu života i razvoja djece rane i predškolske dobi, što upućuje na potrebu definiranja njihovih potreba i problema, utvrđivanje područja u kojima je djeci i njihovim obiteljima potrebno osigurati dodatnu potporu, provjeru dostupnosti i kvalitete takve potpore, definiranje ciljeva, sadržaja i metoda potrebnog odgojno-obrazovnog djelovanja te realizaciju i evaluaciju specifičnih modela potpore. Cilj predloženog projekta je doprinijeti sistematizaciji postojećih i kreiranju novih znanstvenih spoznaja o etiološkim, fenomenološkim i intervencijskim aspektima rizika socijalne isključenosti djece rane i predškolske dobi. Ostvarivanje ovog cilja pretpostavka je daljnjeg osnaživanja ustanova RiPOO u ostvarivanju razvojnih prava djece izložene riziku socijalne isključenosti.Cilj će se ostvariti analizom etioloških, fenomenoloških i intervencijskih aspekata rizika socijalne isključenosti djece putem utvrđivanja udjela djece izložene riziku socijalne isključenosti, karakteristika njima usmjerene pedagoške prakse i dostupnih mjera potpore toj skupini obitelji i djece. Rezultati istraživanja omogućit će komparaciju i kritičku analizu inkluzivnosti ustanova ranog i predškolskog odgoja i obrazovanja (RiPOO). Istraživanje povezuje teorije i metode iz edukacijsko-rehabilitacijske i pedagogijske znanosti te kvantitativne i kvalitativne metode istraživanja, a planira se obuhvat reprezentativno odabranih 60 ustanova RiPOO u Hrvatskoj (djece, roditelja/skrbnika, odgajatelja i stručnih suradnika). Razvit će se mjerni instrumenti za utvrđivanje odgojno-obrazovnih potreba djece izložene riziku socijalne isključenosti, istražiti modeli odgovora ustanova RiPOO na te potrebe, te sistematizirati i razviti lepeza raznolikih, na pokazateljima uspješnosti temeljenih, mjera potpore djeci u sklopu RiPOO.]]></summary_hr><summary_en><![CDATA[Cumulative factors of risk of social exclusion (RSE) multiply unfavourable effect on the quality of children life in early age. That fact emphasizes the necessity for defining children needs and problems, for determination of the fields in which children and their families need support and for the analysis of availability of that support. It emphasizes the necessity for defining goals, content and methods of appropriate educational practice, and  evaluation of the specific models of the support. The objective of the proposed research is to contribute to the systematisation of current and development of new scientifically based findings regarding etiological, phenomenological and intervention aspects of RSE within children in early years. The realization of this objective is an important precondition to further empowerment of early childhood education and care institutions (ECECI) in fulfilling developmental rights of children at RSE. The objective will be achieved by the analysing of etiological, phenomenological, and intervention aspects of RSE of children through the establishing the proportion of children at RSE, characteristics of educational practices directed to these group of children, and available measures of educational support and professional treatment for these families and children. The results will enable a comparative and critical analysis of inclusivity of ECECI. The research interlinks theories and methods within educational-rehabilitation and pedagogical sciences, and quantitative and qualitative methods of data research. The plan is to include at least 60 representative ECECI (children, parents, teachers, and professional support staff). The measurement instruments for establishing educational needs of children at RSE will be developed, models of appropriate response of ECECI to such needs will be analysed, and systematization and development of a range of diverse evidence based interventions in ECECI will be provided.]]></summary_en></project><project>
<id>8462</id><title_hr><![CDATA[Prvi svjetski rat u kulturi sjećanja. Zaboravljena baština]]></title_hr><title_en><![CDATA[The First World War in the Culture of Memory. Forgotten Heritage]]></title_en><user_id>2739</user_id><user_firstLast_name>Ljiljana Dobrovšak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-5897</code><acronim><![CDATA[PSRUKSZB]]></acronim><duration>01.01.2020 - 31.12.2023</duration><status>Završio</status><financ_value>48.603,09 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Povijest, Povijest umjetnosti, Etnologija i antropologija, </scie_field_hr><scie_field_en>History, Art history, Ethnology and anthropology, </scie_field_en><institution_hr><![CDATA[Institut društvenih znanosti Ivo Pilar]]></institution_hr><institution_en><![CDATA[Institute of Social Sciences Ivo Pilar in Zagreb]]></institution_en><team_members_id>4949, 1174, 6522, 12434, 3499, 1005, 26012, 6424, 26340, </team_members_id><team_members_names><![CDATA[Monica Priante, Ivana Žebec Šilj, Mislav Gabelica, Jelka Vince Pallua, Dragan Damjanović, Vijoleta Herman Kaurić, Filip Hameršak, Sandra Cvikić, Danilo Šarenac, ]]></team_members_names><keywords_hr><![CDATA[Prvi svjetski rat, mjesta sjećanja, kultura sjećanja, baština, zaborav]]></keywords_hr><keywords_en><![CDATA[The First World War, Site of memory,  Culture of Memory, Heritage, Forgetting]]></keywords_en><summary_hr><![CDATA[Svrha je ovog istraživanja potaknuti znanstvenu raspravu o &#39;kulturi sjećanja&#39; na Prvi svjetski rat u Hrvatskoj na temelju dobivenih novih spoznaja o istraženoj baštini kako bi se utvrdili uzroci i odgovorilo na pitanje zašto je došlo do suvremenog &#39;fenomena zaborava&#39; na Prvi svjetski rat u Hrvatskoj.Cilj projekta je istražiti &#39;kulturu sjećanja&#39; na Prvi svjetski rat u Hrvatskoj za vrijeme Kraljevine SHS/Jugoslavije (u odnosu na širu regiju i Europu) kroz sustavno upoznavanje s &#39;politikama sjećanja&#39; (zakonodavni okvir), praksama obilježavanja &#39;mjesta sjećanja&#39; i &#39;komemorativnim praksama&#39; tijekom Prvoga svjetskoga rata i u međuratnom razdoblju.Istraživanje uključuje evidentiranje &#39;mjesta sjećanja&#39;, okolnosti njihova nastanka, postavljanja i/ili nestanka, te analiziranje i proučavanje djelatnosti i/ili odnosa hrvatskih institucija, vojnih i civilnih udruženja kao i centralnih institucija, vojnih i civilnih udruženja u Beogradu prema formiranju &#39;mjesta sjećanja&#39; na Prvi svjetski rat u Hrvatskoj.Istovremeno, istraživanje stavlja evidentirana &#39;mjesta sjećanja&#39; u širi društveno-politički kontekst istražujući tadašnji jugoslavenski zakonodavni okvir &#39;politike sjećanja&#39; prema njihovom formiranju kroz komemorativne prakse na svom prostoru, kao i odnos jugoslavenske države i centralnih institucija u Beogradu prema hrvatskim državljanima koji su se nalazili u austrougarskoj vojsci i stradali su boreći se za Austro-Ugarsku Monarhiju.Rezultat ovog primarno povijesnog znanstveno-istraživačkoga projekta multidisciplinarnog karaktera bit će ne samo proširene znanstvene spoznaje o toj zanemarenoj i nedovoljno istraženoj hrvatskoj kulturno-povijesnoj baštini; nego, što je još važnije, omogućuje znanstveno i kulturno integriranje hrvatske &#39;kulture sjećanja&#39; na Prvi svjetski rat i njegove sada valorizirane povijesne baštine u širi društveno-povijesni kontekst Europe.]]></summary_hr><summary_en><![CDATA[The aim of this research is to initiate scholarly debate on the 1st WW ‘cultural memory’ in Croatia based on newly acquired knowledge about its researched cultural heritage in order to determine causes and why it contributed to the contemporary social phenomenon of ‘forgetness’ related to the 1st WW in Croatia. The research objective is to examine the 1st WW ‘cultural memory’ in Croatia at the time of the Kingdom of SHS/Yugoslavia (and in relation to the wider region and Europe) through systematic investigation of ‘memory politics’ (legal framework), ‘sites of memory’ marking practices and ‘commemorative practices’ during the war and in the interwar period.  The first specific research goal is to investigate and record ‘sites of memory’, and to determine circumstances of its creation, establishment and/or disappearance analysing and studying actions and/or attitudes of the Croatian institutions, military and civilian  associations next to the central Belgrade institutions, military and civilian organizations towards 1st WW Croatian ‘sites of memory’. The second specific research goal is to situate the 1st WW ‘sites of memory ’in Croatia in a wider socio-political context investigating how, at the time, Yugoslav legal framework of ‘memory politics’ is developed towards its formation through ‘commemorative practices’ on its territory, as well as, attitudes of the Yugoslav state and central institutions in Belgrade towards Croatian citizens as members of the Austro-Hungarian Army who died fighting for the Austro-Hungarian Monarchy.  The overall result of this predominantly historical research project multidisciplinary in character thus is not only expanded knowledge about neglected and insufficiently researched Croatian cultural and historical heritage; but more importantly; the acquired knowledge enables scientific and cultural integration of the 1st WW Croatian ‘cultural memory’ and its valorised historical heritage into the wider socio-historical European context.]]></summary_en></project><project>
<id>8464</id><title_hr><![CDATA[Glikozilacija u kardiovaskularnim bolestima]]></title_hr><title_en><![CDATA[Glycosylation in Cardiovascular diseases]]></title_en><user_id>25794</user_id><user_firstLast_name>Ivan Gudelj</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2019-04</proposal_call><code>UIP-2019-04-5692</code><acronim><![CDATA[GLYCARD]]></acronim><duration>15.02.2020 - 14.02.2025</duration><status>Završio</status><financ_value>256.818,63 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Fakultet biotehnologije i razvoja lijekova]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Biotechnology and Drug Development]]></institution_en><team_members_id>1017, 26391, 26423, 26611, 27340, 855415, </team_members_id><team_members_names><![CDATA[Maja Pučić Baković, Janko Szavits Nossan, Filip Kliček, Aleksandar Blivajs, Igor Šesto, Barbara Radovani, ]]></team_members_names><keywords_hr><![CDATA[kardiovaskularne blesti, glikozilacija, perosnalizirana medicina, prevencija, imunoglobulin G,]]></keywords_hr><keywords_en><![CDATA[cardiovascular diseases, glycosylation, personalized medicine, prevention, immunoglobulin G]]></keywords_en><summary_hr><![CDATA[Kardiovaskularne bolesti su vodeći uzrok mortaliteta i morbiditeta u svijetu, a poznavanje faktora rizika i molekularnih mehanizama koji su ključni za njihov razvoj uvelike je doprinijelo njihovoj prevenciji i pravovremenom liječenju. Sve više istraživanja ukazuje da promjene glikozilacije, najčešće posttranslacijske modifikacija proteina, imaju važnu ulogu u razvoju kardiovaskularnih bolesti. Koristeći krajnje tehnološke dosege u analizi glikana, kao što su tekućinska kromatografija ultra-visoke djelotvornosti te spregnuta tehinika tekućinske kromatografije sa spektrometrijom masa, ovim projektom ispitat će se povezanost promjena glikozilacije imunoglobulina G, lipoproteina i ukupnih proteina plazme s fibrilacijom atrija, koronarnom bolešću, zatajivanjem srca, primjenom različitih terapija kao i vaskularnim, lipidnim i upalnim biomarkerima rizika za razvoj kardiovaskularnih bolesti. Također, ovim projektom će se ispitati biomarkerski potencijal glikana za prevenciju, ranu dijagnozu te izbor i praćenje terapije za kardiovaskularne bolesti. Nadalje, pokušat će se utvrditi jesu li promjene glikozilacije i svojevrsni faktor rizika koji je neovisan od ostalih, do sada poznatih. Tako da će projekt doprinijeti razumijevanju patologije kardiovaskularnih bolesti te rasvjetljavanju uloge glikana u njihovom razvoju što će potencijalno doprinijeti razvoju novih, na glikanima temeljnenim, testova kojima bi se moglo raditi na prevenciji kao i praćenju bolesti i terapije.Također, suradnja s Klinikom za kardiovaskularne bolesti „Magdalena“ i Zavodom za bolesti srca i krvnih žila Kliničke bolnice  Dubrava će omogućiti rano usvajanje i razvoj  takvog testa u Hrvatskoj, dok će suradnja s Harvard Medical School, Boston, SAD i National Institute for Health and Medical Research, Paris, Francuska olakšati transfer testa na međunarodno tržište.]]></summary_hr><summary_en><![CDATA[Cardiovascular diseases are the leading cause of mortality and morbidity in the world, and knowing risk factors and molecular mechanisms that are crucial for their development has greatly contributed to their prevention and early treatment. A growing body of research indicates that changes in glycosylation, the most common posttranslational modification of proteins, have an important role in the development of cardiovascular diseases. Using the cutting-edge technology for the glycan analysis, such as ultra-high performance liquid chromatography and liquid chromatography–mass spectrometry techniques, this project will study the association between glycosylation changes of immunoglobulin G, lipoproteins and total plasma proteins with atrial fibrillation, coronary disease, heart failure, administration of various therapies as well as vascular, lipid and inflammatory risk biomarkers for the development of cardiovascular disease. Also, this project will investigate the biomarker potential of glycans for prevention, early diagnosis as well as selection and monitoring of a therapy for cardiovascular diseases. Furthermore, the project will try to determine whether glycosylation changes are a risk factor that is independent from others, already known. Thus, the project will contribute to the understanding of the cardiovascular disease pathology and clarify the glycan role in their development, which will potentially advance the development of new, glycan-based tests that can be used for the disease prevention as well as the monitoring of disease and therapy. Also, the collaboration with Clinic for Cardiovascular Diseases “Magdalena” and the Department of Cardiovascular Diseases, University Hospital Dubrava, will enable early adoption and development of such a test in Croatia, while collaboration with Harvard Medical School, Boston, USA and the National Institute for Health and Medical Research, Paris, France will facilitate the transfer of a test to the international market.]]></summary_en></project><project>
<id>8468</id><title_hr><![CDATA[Solidarna ekonomija u Hrvatskoj: antropološka perspektiva]]></title_hr><title_en><![CDATA[Solidarity Economy in Croatia: Anthropological Perspective]]></title_en><user_id>1284</user_id><user_firstLast_name>Olga Orlić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-3946</code><acronim><![CDATA[SOLIDARan]]></acronim><duration>01.02.2020 - 31.01.2024</duration><status>Završio</status><financ_value>79.633,69 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Etnologija i antropologija, </scie_field_hr><scie_field_en>Ethnology and anthropology, </scie_field_en><institution_hr><![CDATA[Institut za antropologiju]]></institution_hr><institution_en><![CDATA[Institute for Anthropological Research]]></institution_en><team_members_id>3724, 25937, 20152, 3749, 11210, 24002, 27390, 828, 1524, 866730, </team_members_id><team_members_names><![CDATA[Aleksandar Lukić, Nataša Bokan, Duga Mavrinac, Anja Ivekovic Martinis, Orlanda Obad, Domagoj Račić, Valentina Valjak, Ana Perinić Lewis, Mirna Jernej Pulić, Ivan Šišak, ]]></team_members_names><keywords_hr><![CDATA[solidarna ekonomija, solidarnost, reciprocitet, zajednica, utopija rekonstrukcije, Hrvatska]]></keywords_hr><keywords_en><![CDATA[solidarity economy,  solidarity, reciprocity, community, utopia of reconstruction, Croatia]]></keywords_en><summary_hr><![CDATA[Nakon početka ekonomske krize 2008. godine, u svijetu i Hrvatskoj dolazi do proliferacije inicijativa „odozdo“, pa tako i društvenih inovacija temeljenih na principima solidarne ekonomije. Solidarna ekonomija obuhvaća skup vrlo raznolikih inicijativa i pokreta fokusiranih na kreiranje i prakticiranje alternativnih načina življenja, proizvođenja i konzumiranja, a time i na transformaciju dominantnog kapitalističkog ekonomskog sustava. To uključuje prakse poput zajedničkog stanovanja, radničkih kooperativa, urbanog vrtlarenja, poljoprivrede potpomognute zajednicom, ekosela, etičnog financiranja, alternativnih valuta, LETSustava, fair-trade inicijativa i drugih. Istraživanje solidarne ekonomije važno je ne samo u hrvatskom kontekstu već i na globalnoj razini, pogotovo stoga što ova tema predstavlja važan spoj kompleksnog područja znanstvenog istraživanja s društvenim i gospodarskim utjecajem koje sam istraživani fenomen ostvaruje. Predloženo bi istraživanje, uključivanjem antropološke perspektive i dijakronijskog pogleda na poimanje solidarnosti u predsocijalističkom, socijalističkom i postsocijalističkom razdoblju, doprinijelo razumijevanju praksi solidarne ekonomije u specifičnom hrvatskom tranzicijskom kontekstu. Glavna istraživačka pitanja fokusirat će se na propitivanje različitih i često međusobno isključivih  konceptualizacija solidarnosti u suvremenosti,  novih oblika zajednica praksi i novih načina zamišljanja zajednica te percepcije solidarne ekonomije kao načina oblikovanja utopije rekonstrukcije. Tako formuliran istraživački fokus doprinijet će razumijevanju procesnosti i višestruke grupne i međugrupne dinamike aktera solidarne ekonomije te teorijskom razmatranju važnih antropoloških pojmova solidarnosti, reciprociteta i zajednica. Značajan primijenjeni cilj projekta sastoji se od izrade modela (smjernica) za implementaciju elemenata solidarne ekonomije u javne politike u Hrvatskoj. ]]></summary_hr><summary_en><![CDATA[Since the start of the economic crisis in 2008, the world and Croatia have seen a proliferation of «bottom-up» initiatives, including social innovations based on the principles of solidarity economy. The solidarity economy comprises an array of diverse initiatives and movements focused on creating and practicing alternative ways of living, producing and consuming and thus also on transforming the dominant economic system. This includes practices such as communal living, workers&#39; cooperatives, urban gardening, community-supported agriculture, ecovillages, ethical financing, alternative currencies, LETS, fair-trade initiatives and others. Research on the solidarity economy is important not only in the Croatian context but on a global level as well, because this subject brings together a complex field of scholarly research and the social and economic influence of the researched phenomenon itself. By including an anthropological perspective and a diachronic view of the conceptualization of solidarity in the presocialist, socialist and postsocialist period, the proposed research would contribute to understanding solidarity economy practices in the specific Croatian context. The central research questions regard the different and often mutually exclusive conceptualizations of solidarity in the contemporary moment, new forms of communities of practice and new ways of imagining communities, as well as perceptions of the solidarity economy as a way of creating a utopia of reconstruction. The research will contribute to understanding the processual nature and the multiple intra- and intergroup dynamics among the actors of the solidarity economy, as well as to the theoretical consideration of the important anthropological concepts of solidarity, reciprocity and communities. The applied objective of the project consists in developing a model (guidelines) for the implementation of elements of the solidarity economy into public policy.]]></summary_en></project><project>
<id>8474</id><title_hr><![CDATA[Radionuklidi u dječjoj hrani i razvoj metoda za određivanje njihovih niskih aktivnosti ]]></title_hr><title_en><![CDATA[Radionuclides in children food and novel methods for low level activity determination ]]></title_en><user_id>19525</user_id><user_firstLast_name>Ivana  Tucaković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-1401</code><acronim><![CDATA[RiChFALL]]></acronim><duration>01.02.2020 - 31.01.2024</duration><status>Završio</status><financ_value>125.423,05 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Interdisciplinarne prirodne znanosti, Fizika, Geologija, Kemija, Biologija, </scie_field_hr><scie_field_en>Interdisciplinary natural sciences, Physics, Geology, Chemistry, Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>19245, 3035, 19321, 19522, 19700, 3809, 19436, 26797, 439, 2881, 867523, </team_members_id><team_members_names><![CDATA[Željko Grahek, Katja Magdić Košiček, Ivana Coha, Gorana Karanović, Delko Barišić, Damir Bosnar, Ivana Smičiklas, Nikola Marković, Dijana Pavičić-Hamer, Božena Skoko, Luka Bakrač, ]]></team_members_names><keywords_hr><![CDATA[Dječja hrana,  radionuklidi, ingestijska doza, aktivni štitovi, niske aktivnosti, automatizacija i integracija metoda separacije i detekcije]]></keywords_hr><keywords_en><![CDATA[Children food, radionuclides, ingestion dose, active shields, low activity, automatization and integration of separation and detection methods]]></keywords_en><summary_hr><![CDATA[Za ljudsko zdravlje vrlo je važno utvrđivanje točnog unosa prirodnih i umjetnih radionuklida u organizam kako bi se što pouzdanije mogao procijeniti zdravstveni rizik od unutarnjeg ozračenja kako za pojedinca tako i za pojedine starosne skupine u populaciji, a osobito za djecu -  populacijsku skupinu najosjetljiviju na izloženost radionuklidima. Stoga su u svijetu provedene brojne studije o sadržaju radionuklida u mlijeku koji predstavlja glavnu osnovnu hranu u prvih šest mjeseci prehrane djece. No, postoji nedostatak podataka o sadržaju radionuklida u drugim vrstama dječje hrane koja se koristi nakon navršenih šest mjeseci života. Prema dostupnim izvorima, u našoj zemlji nisu do sada rađena sustavna istraživanja o radiološkoj ispravnosti dječje hrane pa tako ni procjene rizika od unutarnjeg ozračenja za tu populaciju. Stoga smatramo da ovo istraživanje ima općedruštvenu važnost jer bi se po prvi puta utvrdilo kakva je kvaliteta dječje hrane s obzirom na sadržaj radionuklida te kojem su riziku naša djeca u tom pogledu izložena. Jedan od glavnih ciljeva istraživanja je provesti sveobuhvatnu analizu dugoživučih alfa, beta i gama emitera, kako prirodnih tako i umjetnih, u gotovoj dječjoj hrani dostupnoj na tržištu te sirovinama za njenu proizvodnju. Stoga se ovim projektom planira poboljšanje postojećih i razvijanje novih metoda određivanja niskih aktivnosti gama emitera uvođenjem pasivnih i aktivnih štitova u svrhu redukcije pozadinskog zračenja, te razvoj novih automatiziranih postupaka istovremene izolacije i separacije ciljanih radionuklida iz kompleksnih uzoraka s ciljem pojednostavljenja i ubrzanja u odnosu na postojeće metode. Ovim projektom razvijene metode moći će se primjenjivati i u drugim područjima kao što je nuklearna forenzika, karakterizacija materijala, praćenje kontaminacija zbog ispusta iz nuklearnih elektrana, u slučaju izvanrednih događaja ili pak pri skladištenju ili odlaganju radioaktivnog otpada i drugo.  ]]></summary_hr><summary_en><![CDATA[The accurate determination of the natural and artificial radionuclides intake in human body is very important in order to ascertain the health risk of internal irradiation of the individual as well as for different age groups in the population, especially for children - the most vulnerable to exposure to radionuclides . Therefore, numerous studies on the content of radionuclides in milk, the main food in the first six months of children&#39;s diet, have been conducted all over the world. However, there is a lack of data in other types of children food used in nutrition after six months of age. According to available sources for our country, there was no systematic research carried out on radiological safety of children food and neither for the risk assessment of internal irradiation for this population. Therefore, we consider this research to be of general importance because, for the first time, it would reveal the quality of children food with regard to the content of radionuclide and it would also indicate the level of risk of children&#39;s exposure. One of the main research goals is to carry out a comprehensive analysis of long-lived alpha, beta and gamma emitters, both natural and artificial, in ready-to-eat children food available on the market, and in raw materials for its production. Therefore, within this project we tend to improve the existing and develope the novel methods for low level activity gamma emitters determination by introducing passive and active shields to reduce the background signal, as well as  to develop the new automated simultaneous isolation and separation procedures of target radionuclides from complex samples. Additional value of this project is that the methods here developed can then also be applied in other domains such as nuclear forensics, material characterization, contamination monitoring due to the discharge from nuclear power plants, in the emergency situations or in the storage or disposal of radioactive waste monitoring, etc.]]></summary_en></project><project>
<id>8478</id><title_hr><![CDATA[Terapijski potencijal neurosteroida i neurotrofina u demenciji]]></title_hr><title_en><![CDATA[Therapeutic potential of neurosteroids and neurotrophins in dementia]]></title_en><user_id>1059</user_id><user_firstLast_name>Dubravka Švob Štrac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-6100</code><acronim><![CDATA[TePoNeDe]]></acronim><duration>01.02.2020 - 30.06.2024</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>4875, 4477, 4478, 13090, 23692, 23792, 23672, 23665, 22640, 1023, 1022, 1306, 858339, 865092, </team_members_id><team_members_names><![CDATA[Ninoslav Mimica, Suzana Uzun, Oliver Kozumplik, Julija Erhardt, Dóra Zelena, Erika Pinter, Coral Barbas, Marcela Konjevod, Lucija Tudor, Matea Nikolac Perković, Gordana Nedić Erjavec, Nela Pivac, Barbara Vuić, Tina Miloš, ]]></team_members_names><keywords_hr><![CDATA[neurosteroidi DHEA i DHEAS, neurotrofin BDNF, demencija, neuroprotekcija, stanični i animalni modeli, ispitanici ]]></keywords_hr><keywords_en><![CDATA[neurosteroids DHEA and DHEAS, neurotrophin BDNF, dementia, neuroprotection, cellular and animal models, human subjects]]></keywords_en><summary_hr><![CDATA[Demencija predstavlja sindrom globalnog i progresivnog propadanja kognitivnih sposobnosti, koji obično pogađa starije osobe. Kako se tijek demencije za sada ne može zaustaviti te s obzirom na ubrzano starenje stanovništva i produljenje životnog vijeka, u skoroj budućnosti demencija će postati jedan od vodećih globalnih problema. Neurosteroidi poput dehidroepiandrosterona (DHEA) i njegovog sulfata (DHEAS), kao i neurotrofini poput moždanog neurotrofnog čimbenika (BDNF), uključeni su u brojne važne funkcije mozga poput neuralne plastičnosti, učenja, pamćenja i ponašanja te pokazuju potencijal u prevenciji i liječenju demencija. Cilj projekta je istražiti neuroprotektivni potencijal i mehanizme djelovanja DHEA(S) i BDNF u demenciji, kombinacijom staničnih, animalnih i istraživanja na ispitanicima. Stanični i molekularni mehanizmi protektivnog djelovanja DHEA(S) i BDNF s posebnim naglaskom na ulogu PI3K signalnog puta istražiti će u primarnoj kulturi neurona C57BL/6 miša tretiranoj Aß-oligomerima kao in vitro modelu Alzheimerove bolesti (AB). Transgeničnim animalnim modelom AB (3xTg-AD miševi), istražiti će se mehanizmi protektivnog djelovanja DHEA(S), s fokusom na promjene BDNF-a i PI3K signalnog puta, in vivo testiranjem kognitivnih funkcija testovima ponašanja te ex vivo analizom patohistoloških, neurokemijskih i strukturnih promjena u tkivu i prerezima mozga, kao i metabolomskog profila u plazmi miševa. U ispitanika sa demencijama i blagim spoznajnim poremećajem (MCI), istražiti će se genetski (BDNF i SULT2A polimorfizmi) i epigenetski (DNA metilacija BDNF promotora) čimbenici uključeni u ekspresiju i regulaciju BDNF i DHEA(S) te povezanost njihove koncentracije u plazmi sa simptomima demencije. Dobiveni rezultati trebali bi pridonijeti boljem razumijevanju složene patofiziologije demencija, razvoju lako dostupnih biokemijskih, metabolomskih i (epi)genetičkih biomarkera u svrhu ranog otkrivanja i praćenja bolesti te novih pristupa u prevenciji i liječenju demencija.]]></summary_hr><summary_en><![CDATA[Dementia is a syndrome of global and progressive deterioration of cognitive skills, which usually affects the elderly. As dementia course for now cannot be halted, given the aging population and increased life expectance, dementia will become one of the leading global problems in near future. Neurosteroids dehydroepiandrosterone (DHEA) and its sulphate (DHEAS), as well as neurotrophin brain derived neurotrophic factor (BDNF) are involved in numerous brain functions such as neural plasticity, learning, memory and behaviour, showing potential in dementia prevention and treatment. The project aims to elucidate neuroprotective effects and mechanisms of DHEA(S) and BDNF in dementia by combining cellular, animal and human research. Cellular and molecular mechanisms of DHEA(S) and BDNF protective effects with emphasis on PI3K-Akt signalling pathway will be evaluated using primary C57BL/6 mouse neuronal culture treated with Aß-oligomers as in vitro model of Alzheimer’s disease (AD). Using transgenic animal AD model (3xTg-AD mice), mechanisms of DHEA(S) protective actions with focus on alternations in BDNF and PI3K signalling pathway, will be evaluated in vivo by behavioral testing of cognitive functions and ex vivo by analysis of pathohystological, neurochemical and structural changes in brain tissue and slices, as well as metabolomic profile in mouse plasma. In subjects with dementia and mild cognitive impairment (MCI), genetic (BDNF and SULT2A polymorphisms) and epigenetic (BDNF DNA methylation) factors, involved in BDNF and DHEA(S) expression and regulation, as well as association of their plasma concentrations with dementia symptoms will be evaluated. Obtained results should contribute to better understanding of complex cellular and molecular pathophysiology of dementia, development of easy available biochemical, metabolomic and (epi)genetic biomarkers for an early detection and disease course monitoring, as well as novel approaches in dementia prevention and treatment.]]></summary_en></project><project>
<id>8480</id><title_hr><![CDATA[Školjkaši: Arhiva okolišnih promjena u obalnim morskim ekosustavima]]></title_hr><title_en><![CDATA[Bivalves: Archives of environmental Change in the coastal Marine Ecosystems]]></title_en><user_id>667</user_id><user_firstLast_name>Melita Peharda Uljević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-8542</code><acronim><![CDATA[BivACME]]></acronim><duration>01.03.2020 - 29.06.2024</duration><status>Završio</status><financ_value>149.319,80 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, Interdisciplinarne prirodne znanosti, </scie_field_hr><scie_field_en>Biology, Interdisciplinary natural sciences, </scie_field_en><institution_hr><![CDATA[Institut za oceanografiju i ribarstvo]]></institution_hr><institution_en><![CDATA[Institute of Oceanography and Fisheries]]></institution_en><team_members_id>25078, 670, 25864, 25869, 2903, 3525, 25807, 5215, 5818, 5837, 19180, </team_members_id><team_members_names><![CDATA[Hana Uvanović, Daria Ezgeta Balić, Thébault Julien, Milica Mandić, Carlotta Mazzoldi, Hrvoje Mihanović, Schöne Bernd R., Krešimir Markulin, Jasna Arapov, Ivan Župan, Clea Denamiel, ]]></team_members_names><keywords_hr><![CDATA[sklerokronologija, školjkaši, ekologija mora, okolišne promjene, atmosfer-ocean klimatski modeli, geokemija ljuštura]]></keywords_hr><keywords_en><![CDATA[sclerochronology, bivalve, marine ecology, environmental change, atmosphere-ocean climate model, shell geochemistry]]></keywords_en><summary_hr><![CDATA[Sklerokronologija je supra disciplinarno područje, u kojem se zone prirasta u čvrstim dijelovima morskih organizama i geokemijske varijacije u njima koriste za stvaranje neprekidnog, više desetljeća dugog, vremenskog niza o rastu organiztama i varijabilnosti morskog okoliša. Projekt BivACME primijenit će sklerokronološki pristup u proučavanju nekoliko kraće živućih gospodarsko važnih vrsta školjkaša (Callista chione, Venus verrucosa, Pecten jacobaeus, Aequipecten opercularis) kao i zaštićene mediteranske endemske vrste školjkaša (Pinna nobilis). Uzorkovanja će se geografski protezati preko hrvatskih granica, a obuhvatit će talijanski dio sjevernog Jadrana, kao i južni Jadran koji pripadaju Crnoj Gori, kako bi uključio širi geografski i okolišni gradijent. Istraživačke aktivnosti temeljit će se na analizi zona prirasta, stabilnih izotopa kisika i ugljika u ljušturama i zapisa elemenata u ljušturama. Nadalje, u ovom projektu planiramo uključiti analizu izotopa dušika u ljušturama, kao i tkiva školjkaša, kako bismo analizirali promjene u priobalnom morskom okolišu. Najbolji raspoloživi proizvod, dugoročna simulacija AdriSC-a (1987.-2017.), koristit će se za kvantificiranje veza između parametara dobivenih iz školjkaša i varijabilnosti okoliša. Rezultati projekta BivACME pridonijet će razvoju metoda za procjenu ekoloških čimbenika rasta školjkaša, kao i uvid u procese i trendove koji bi mogli biti korisni za pravilnu kvantifikaciju prošlih promjena u okolišu. Ciljane vrste su gospodarski važne, stoga će predloženo istraživanje doprinijeti znanju potrebnom za omogućavanje održivog iskorištavanja školjkaša i akvakulture u promjenjivim morskim obalnim ekosustavima.]]></summary_hr><summary_en><![CDATA[Sclerochronology is a supra disciplinary field, where growth increments in hard parts of marine organisms and geochemical variations are used to generate uninterrupted multi decadal time-series of growth and marine environmental variability. BivACME project will apply sclerochronology approach to study of several shorter living commercially important bivalve species (Callista chione, Venus verrucosa, Pecten jacobaeus, Aequipecten opercularis) as well as protected Mediterranean endemic bivalve Pinna nobilis. Sampling will extend geographically, over Croatian boundaries, and will include Italian part of the northern Adriatic Sea as well as southern Adriatic waters that belong to Montenegro, in order to encompasses a wider geographical and environmental gradient. Research activities will be based on the analysis of growth increments, oxygen and carbon isotopes and element records in shell. Furthermore, in this project we plan to include analysis of nitrogen isotopes in the shell, as well as in bivalve tissue, to analyse changes in coastal marine environment. The best available product, the AdriSC long-term simulation (1987-2017), will be used in quantifying connections between bivalve-derived parameters and environmental variability. Results of the BivACME project will contribute toward developing methods for assessment of environmental drivers of bivalve growth, as well as provide an insight into processes and trends which might be useful for proper quantification of the past changes in the environment.  Target species are commercially important, thus, the proposed research will contribute to knowledge needed for enabling sustainable bivalve harvesting ad aquaculture in changing marine coastal ecosystems.]]></summary_en></project><project>
<id>8486</id><title_hr><![CDATA[Procjena granične nosivosti inženjerskih konstrukcija]]></title_hr><title_en><![CDATA[Estimation of limit load capacity of engineering structures]]></title_en><user_id>3329</user_id><user_firstLast_name>Domagoj Lanc</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-8615</code><acronim><![CDATA[LOCAPES]]></acronim><duration>01.12.2019 - 30.11.2023</duration><status>Završio</status><financ_value>100.802,97 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, Temeljne tehničke znanosti, </scie_field_hr><scie_field_en>Mechnical engineering, Basic engineering sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Tehnički fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Engineering]]></institution_en><team_members_id>3309, 3256, 3328, 3332, 17760, 23703, </team_members_id><team_members_names><![CDATA[Goran Turkalj, Josip Brnić, Igor Pešić, Sanjin Kršćanski, Damjan Banić, Sandra Kvaternik, ]]></team_members_names><keywords_hr><![CDATA[Granična nosivost, Grede, Mehaničke značajke, Kompoziti, Numeričke simulacije]]></keywords_hr><keywords_en><![CDATA[Limit load capacity, Beams, Mechanical properties, Composites, Numerical simulations]]></keywords_en><summary_hr><![CDATA[S ciljem projektiranja konstrukcije željene pouzdanosti, sigurnosti i funkcionalnosti neophodno je sagledati sve relevantne čimbenike kao što su vjek trajanja, materijalne značajke, uvjeti eksploatacije, i dr. Novi pristupi u konstruiranju, s obzirom na rapidan novih naperednih materijala praćen razvojem inovativnih tehnologija, za razliku od konvencionalnih, zahtjevaju adekvatan razvoj novih naprednih algoritama prosudbe. Uz eksperimentalna ispitivanja kao zasigurno najpouzdaniji pristup, numeričke se simulacije zbog smanjenja troškova nameću kao nužnost. Iskustvo članova projektnog tima u razvoju numeričkih modela, poglavito u domeni simulacija konstrukcija grednog tipa te u eksperimentalnom utvrđivanju nosivosti konstrukcijskih elemenata, čini okosnicu ovoga projektnog prijedloga. Dio će istraživanja biti posvećen razvoju novih i nadogradnji postojećih numeričkih simulatora za analizu prostornih grednih konstrukcija s posebnim naglaskom na kompozitne konstrukcije u režimu ekstremnih uvjeta, npr. povišenoj temperaturi. Cilj simulacija biti će procjena moći nošenja konstrukcije, odnosno predviđanje graničnog stanja s osvrtom na razloge nastupanja kolapsa. S obzirom na krucijalnu važnost pravilnog izbora materijala, eksperimentalna identifikacija materijalnih značajki iznimno je bitna; stoga će ovo istraživanje objediniti i aktivnosti statičkih i dinamičkih eksperimentalnih ispitivanja različitih konstrukcijskih materijala s naglaskom na do sada nedostupne mahaničke parametre specijalnih metalnih materijala, kako u normalnim tako i u uvjetima graničnih stanja. To je od iznimne važnosti za njihovu uporabu u odgovarajućim uvjetima eksploatacije a predstavlja potporu cjelovitom modelu prosudbe. Dobiveni podaci doprinjet će formiranju novih i nadopuni postojećih baza materijalnih značajki s ciljem podloge računalnim simulatorima. Uspostava novih metoda procjene granične nosivosti bazirat će se na novorazvijenim numeričkim algoritmima kao konačnom cilju ovoga projekta.]]></summary_hr><summary_en><![CDATA[Structural design acounting for desired reliability, safety and functionality, must consider all relevant factors such as lifespan, material parameters, exploitation conditions, etc. The new approaches, due to the advanced materials and rapid development of innovative technologies, contrary to conventional ones, require the development of new advanced estimation algorithms. While the experimental tests are surely the most reliable, numerical simulations, due to the cost reductions, are imposed as necessity. The experience of team members in the development of numerical models, especially in the field of simulation of the beam type construction and in the experimental determination of the load capacity of the structural elements, form the backbone of this project proposal. The part of the research will be devoted to the development of new and upgrading of existing numerical simulators for the analysis of spatial structures with special emphasis on composite structures in the regime of extreme conditions, eg elevated temperature. The aim of the simulations will be to estimate the load carrying capacity of structure, ie to predict the limit state with a review of the reasons of collapse. Due to the crucial importance of the proper material selection, the experimental identification of material features is extremely important; therefore, this study will combine the activities of static and dynamic experimental testing of different construction materials with emphasis on the unavailable mechanical parameters of special materials, both in normal and in the ultimate states. This is of utmost importance for their use under extreme conditions of exploitation and contribute as a support to the comprehensive model of assessment. The obtained data will contribute to material bases extension and as a support to computer simulators. The establishment of new methods for limit loads estimation will be based on newly developed numerical algorithms, the main goal of this project.]]></summary_en></project><project>
<id>8490</id><title_hr><![CDATA[Dopaminska regulacija kompetitivnog ponašanja u kohabituirajućim populacijama guštera Podarcis siculus i Podarcis melisellensis]]></title_hr><title_en><![CDATA[Dopamine regulation of competitive behavior in coexisting populations of lizards Podarcis siculus and Podarcis melisellensis]]></title_en><user_id>12445</user_id><user_firstLast_name>Sofia Ana Blažević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2019-04</proposal_call><code>UIP-2019-04-8469</code><acronim><![CDATA[BOLDer]]></acronim><duration>01.01.2020 - 30.06.2025</duration><status>Završio</status><financ_value>262.127,55 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>24034, 22727, 855417, 858391, 13161, 3008, 866677, 868780, </team_members_id><team_members_names><![CDATA[Marko Glogoški, Zoran Marčić, Tomislav Gojak, Dunja Šikić, Duje Lisičić, Lana Pađen, Josip Miljković, Matea Brižić, ]]></team_members_names><keywords_hr><![CDATA[ponašanje životinja, agresivno ponašanje, neuroetologija, neurotransmiteri, dopamin, HPLC, ekspresija gena, Podarcis, Lacertidae, competitive species]]></keywords_hr><keywords_en><![CDATA[animal behavior, aggresive behavior, neuroethology, neurotransmitters, dopamine, HPLC, gene expression, Podarcis, Lacertidae, competitive species]]></keywords_en><summary_hr><![CDATA[Agresivna i socijalna ponašanja utječu na dinamiku populacije, reprodukciju i raspodjelu energije unutar populacije. Ove paradigme ponašanja su rezultat monoaminskih neurotransmitera u mozgu – serotonin, dopamin (DA) i noradrenalin. Ovi neurotransmiteri su slabo proučeni u divljih životinja, u kojima uzročno-posljedične veze često nisu primjetne zbog fizioloških i bihevioralnih oscilacija unutar divljih populacija. Gušteri, amniotski kralježnjaci, usprkos tome što imaju jednostavniji mozak od sisavaca, s njima dijele u moždanom deblu zajednički neuronske krugove koji su odgovorni za motivacijsko ponašanje, uključujući agresiju. Ovaj jednostavniji mozak pogodan je za proučavanje temeljnih mehanizama kontrole ponašanja, s rezultatima koji se mogu translatirati na druge vrste. Poznato je da u istočnom Jadranu, Podarcis siculus, globalna invazivna vrsta, kompetitivno isključuje autohtonu Podarcis melisellensis. Nedavno smo pokazali u P. siculus dvostruko više dopamina nego u P. melisellensis. Projekt BOLDer ima za cilj proučiti ovaj jedinstveni model kohabituirajućih vrsta guštera kako bi razjasnili odnos između razlika u razinama neurotransmitera u mozgu i ekološku isključenost ovih vrsta. Konkretno, planiramo: 1) potvrditi razlike među vrstama u razinama DA u mozgu ove dvije vrste u različitm simpatrijskim populacijama (HPLC); 2) povezati ove razlike sa specifičnim komponentama agresivnog ponašanja (in situ i laboratorijska ispitivanja ponašanja); 3) ispitati stukturalne (histološko/imunohistokemijske) i transkripcijske (NGS transkriptoma i qRT-PCR) mehanizme koji određuju te razlike. BOLDER će formalno osnovati prvu neuroetološku istraživačku skupinu na Prirodoslovno-matematičkom fakultetu, koja će, svojim komparativnim pristupom, pokušati razjasniti osovinu koja povezuje agresivno ponašanje s regulacijom razine/aktivnosti neurotransmitera.]]></summary_hr><summary_en><![CDATA[Behaviors of aggressive and social character shape population dynamics, reproductive output, and energy balance within populations. These behavioral paradigms are the result of the activity of brain monoamine neurotransmitters – serotonin, dopamine (DA), and noradrenaline. These neurotransmitters are vastly understudied in wild animals and often, their causative roles in behavior are not directly evident due to behavioral and physiological variability within populations. Lizards, amniotic vertebrates, have simpler brains than mammals yet share with them common neural circuits in the brainstem that are responsible for motivational behavior including aggression. This simpler brain is favorable for studying underlying mechanisms of behavioral control, and the results could be translated to other species. It is well known that in the Eastern Adriatic, Podarcis siculus, a global invasive species, competitively excludes the native Podarcis melisellensis. We have recently demonstrated that P. siculus has twice as much dopamine in brain than P. melisellensis. The project BOLDer aims to study this unique model of coexisting lizards’ species to understand the relationship between differences in brain neurotransmitter content and ecological exclusion of these species. Specifically, we plan to:  1) demonstrate the interspecific differences in brain DA  levels between these two species across different sympatric populations (HPLC); 2) link these differences with specific components of aggressive behavior (in situ and lab. behavioral testing); and 3) examine structural (histology/immunohistochemistry) and transcriptional (transcriptome NGS and qRT-PCR) mechanisms that determine these differences. BOLDer will formally establish the first neuroethological research group at the Faculty of Science, that will, with its comparative approach, try to clarify the axis that links aggressive behavior with the regulation of neurotransmitter levels/activity.]]></summary_en></project><project>
<id>8491</id><title_hr><![CDATA[Integrin alpha V beta 5-povezane fokalne i retikularne adhezije u melanomu]]></title_hr><title_en><![CDATA[Integrin alpha V beta 5-associated Focal and Reticular Adhesions in Melanoma]]></title_en><user_id>1211</user_id><user_firstLast_name>Andreja Ambriović Ristov</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-1577</code><acronim><![CDATA[AdMeFoRe]]></acronim><duration>01.02.2020 - 31.01.2024</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>2888, 26000, 17822, 856302, 22598, </team_members_id><team_members_names><![CDATA[Nikolina Stojanović, Jonathan Humphries, Ksenija Božinović, Marija Tomić, Anja  Rac, ]]></team_members_names><keywords_hr><![CDATA[melanom, integrin alpha V beta 5, adhesom, kompleks adhezije integrina, fokalna adhezija, retikularna adhezija, paklitaksel, migracija, invazija]]></keywords_hr><keywords_en><![CDATA[melanoma, integrin alpha V beta 5, adhesome, integrin adhesion complex, focal adhesion, reticular adhesion, paclitaxel, migration, invasion]]></keywords_en><summary_hr><![CDATA[Ciljana terapija i/ili inhibitori imunosnih kontrolnih točaka neuspješni su pri liječenju velikog broja bolesnika s melanomom te se oni liječe klasičnim protutumorskim lijekovima, poput paklitaksela (PTX) koji nije toliko učinkovit u melanomu kao što je to slučaj u drugim tipovima tumora. Ne postoje lijekovi za inhibiciju pokretljivosti, a time i invaziju i širenje stanica melanoma. Stoga, postoji hitna potreba za razvojem inovativnih metoda za poboljšanje učinkovitosti PTX i za inhibiciju metastaziranja. Integrini, receptori na površini stanica, predstavljaju potencijalne ciljne molekule za tu svrhu. Vezanje integrina alpha v beta 5 na izvanstanični matriks dovodi do stvaranja velikih kompleksa proteina povezanih s membranom nazvanih fokalne adhezije (FA) i novootkrivenih kompleksa nazvanih retikularne adhezije (RA). Naši nedavno objavljeni podaci pokazali su, u dvije stanične linije melanoma, da utišavanje integrinske podjedinice alpha V povećava osjetljivost na PTX i istodobno smanjuje migraciju i invaziju stanica, a učinak smo pripisali integrinu alpha V beta 5. Analizirali smo sastav kompleksa adhezije i otkrili da obje stanične linije melanoma pretežno koriste integrin alpha V beta 5 i, nakon utišavanja integrina alpha V, identificirali specifične proteine u kompleksu adhezije. Hipoteza ovog projekta je da proteini integrin alpha V beta 5-povezanih FA ili RA mogu predstavljati izvrsne mete za povećanje osjetljivosti na PTX, smanjenje migracije i invazije stanica melanoma. U okviru ovog projekta analizirat ćemo molekularni sastav FA i RA te ulogu njihovih komponenti u stvaranju FA ili RA, citoskeleta aktina i mikrotubula, osjetljivosti stanica na PTX, migraciji i invaziji dviju staničnih linija melanoma. Ovaj će projekt povećati temeljna znanja o FA i RA i ima potencijal otkriti nove ciljne molekule koje bi se mogle koristiti u terapiji melanoma.]]></summary_hr><summary_en><![CDATA[Targeted agents and/or immune checkpoint inhibitors still fail in a substantial portion of melanoma cases and patients are treated with conventional antitumor drugs, such as paclitaxel (PTX) which is usually not as effective for melanoma as it is for some other types of tumours. There are no drugs available that inhibit motility, invasion and dissemination of melanoma. Therefore, there is an urgent need to develop innovative methods for improving effectiveness of PTX and to inhibit metastasis. Integrins, receptors on the cell surface, are the potential target molecules for this purpose. Ligation of integrin alpha V beta 5 to extracellular matrix leads to formation of large membrane-associated complexes called focal adhesions (FA) and newly discovered reticular adhesions (RA). Our recently published data has shown, in two melanoma cell lines, that the knockdown of integrin subunit alpha V increases the sensitivity to PTX and concurrently decreases cell migration and invasion and we ascribed this effect to integrin alpha V beta 5. We analysed the composition of adhesion complexes and discovered that both melanoma cell lines predominantly use integrin alpha V beta 5 and, upon integrin alpha V knockdown, we identified specific proteins within adhesion complexes. The hypothesis of this project is that proteins of the integrin alpha V beta 5-associated FA or RA may serve as excellent targets to achieve increased sensitivity to PTX, and, concurrently, decreased cell migration and invasion. Within this project we will reveal the molecular composition of integrin alpha V beta 5-associated FA and RA and analyse the role of its components in formation of FA and RA, actin and microtubule cytoskeletons, cell sensitivity to PTX, migration and invasion in two melanoma cell lines. This project will increase the fundamental knowledge on FA and RA, and has the potential to identify new target molecules within adhesion proteins that might be used in melanoma therapy.]]></summary_en></project><project>
<id>8492</id><title_hr><![CDATA[Interdisciplinarni pristup hrvatskoglagoljskomu misalu na primjeru Misala kneza Novaka ]]></title_hr><title_en><![CDATA[An Interdisciplinary Approach to the Glagolitic Missal on the Example of the Missal of Count Novak]]></title_en><user_id>25732</user_id><user_firstLast_name>Sandra Požar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-3797</code><acronim><![CDATA[NOMIS]]></acronim><duration>01.02.2020 - 31.01.2024</duration><status>Završio</status><financ_value>45.855,73 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Interdisciplinarne humanističke znanosti, Teologija, Filologija, Povijest, </scie_field_hr><scie_field_en>Interdisciplinary humanities, Theology, Philology, History, </scie_field_en><institution_hr><![CDATA[Staroslavenski institut]]></institution_hr><institution_en><![CDATA[Old Church Slavonic Institute in Zagreb]]></institution_en><team_members_id>25733, 23406, 25724, 25749, 6666, 865512, </team_members_id><team_members_names><![CDATA[Andrea Radošević, Ivan Botica, Kristijan Kuhar, Silvio Košćak, RENHART Erich, Thomas Klampfl, ]]></team_members_names><keywords_hr><![CDATA[srednjovjekovna Crkva, rimski obred, hrvatskoglagoljski misal, Biblija, hrvatski crkvenoslavenski jezik, glagoljica, srednjovjekovno plemstvo]]></keywords_hr><keywords_en><![CDATA[medieval Church, Roman Rite, Croatian Glagolitic missal, Bible, Croatian Church Slavonic language, Glagolitic script, medieval nobility]]></keywords_en><summary_hr><![CDATA[U fokusu je predloženoga interdisciplinarnog istraživanja jedan od najstarijih cjelovito sačuvanih i najstariji datirani hrvatskoglagoljski misal, Misal kneza Novaka ili Novakov misal, iz 1368. godine. Prepisao ga je, kako je navedeno u opširnu kolofonu samog kodeksa, knez Novak Disislavić od roda Mogorovića, vitez anžuvinske vladarske kuće dok je bio upraviteljem Nina u Hrvatskoj i Salgóa u Mađarskoj. Novakov je misal osobito vrijedan po tome što je bio predložak prvoj hrvatskoj tiskanoj knjizi Misalu po zakonu rimskog dvora, otisnutoj 22. veljače 1483., ujedno i prvoj nelatiničnoj tiskanoj knjizi zapadne civilizacije. Znanstveno je dokazana njihova poveznica u tekstu, jeziku i pismu (Pantelić 1967), ali i u svjedočanstvu o skoru tiskanju misala zabilježenom na posljednjoj stranici Novakova misala. Predloženo istraživanje bavi se liturgijskopovijesnim, filološkim, teološkopovijesnim, književnopovijesnim i historiografskim istraživanjima Misala kneza Novaka. Glavni je cilj digitalna obrada strukture Misala, koja će moći služiti kao osnova za daljnja istraživanja i objavljivanje tekstova. Obrada strukture temeljit će se na metodologiji istraživanja latinskih misala, opisanoj u disertaciji člana istraživačke grupe K. Kuhara (Kuhar 2017). Glavni rezultat projekta bit će digitalna konkordancija Misala. Projekt će se provoditi na Staroslavenskom institutu, a u suradnji s Centrom za istraživanje rukopisa i pisane baštine Vestigia iz Graza. Istraživačka grupa sastoji se od tri teologa, dvije filologinje, jednog povjesničara, jednog digitalnog humanista i jedne informatologinje. ]]></summary_hr><summary_en><![CDATA[The focus of the proposed interdisciplinary research is one of the oldest wholly preserved and the oldest dated Croatian Glagolitic missal, the Missal of count Novak or the Novak’s Missal, dating from 1368. It was written, as stated in the extensive colophon of the manuscript itself, by count Novak Disislavić of the kindred Mogorović, a knight of the Anjou Royal House while he was the governor of Nin in Croatia and Salgó in Hungary. Novak&#39;s missal is particularly valuable in that it was used as a pattern for the first Croatian printed book (incunabulum), Missal according to the law of the Roman court, printed on February 22 1483, also the first printed book of Western civilization in alphabet that was not Latin. Their link in text, language and script has been scholarly proven (Pantelić 1967), as well as in the testimony of the upcoming printing of the Missal recorded on the last page of the Novak&#39;s Missal. The proposed research deals with liturgical-historical, philological, theological-historical, literary-historical and historiographical research of the Novak’s Missal. The main goal is digital processing of the structure of the Missal, which will serve as a basis for further research and publication of texts. The elaboration of the structure will be based on methodology of Latin missal research, described in the dissertation of a member of the research group K. Kuhar (Kuhar 2017). The main result of the project will be the digital concordance of the Missal. The project will be implemented in the Old Church Slavonic Institute, in collaboration with the Centre for Manuscript Studies Vestigia from Graz. The research group consists of three theologians, two philologists, one historian, one digital humanist/theologian and one informatologist.]]></summary_en></project><project>
<id>8494</id><title_hr><![CDATA[Mikro i nano-strukture za 3D opto-bioelektroniku]]></title_hr><title_en><![CDATA[Micro- and nano-structures for 3D opto-bioelectronics]]></title_en><user_id>4750</user_id><user_firstLast_name>Vedran Đerek</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2019-04</proposal_call><code>UIP-2019-04-1753</code><acronim><![CDATA[3Doptobio]]></acronim><duration>01.01.2020 - 31.03.2025</duration><status>Završio</status><financ_value>258.384,76 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, Kemija, Biologija, Interdisciplinarne prirodne znanosti, </scie_field_hr><scie_field_en>Physics, Chemistry, Biology, Interdisciplinary natural sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>26410, 19451, 25316, 12975, 26663, 864847, 866658, 867693, </team_members_id><team_members_names><![CDATA[Malin Silvera Ejneby, Kristina Serec, Kamran ali Syed , Nikola Habek, Aleksandar Opančar, Anja Mioković, Tony Schmidt, Karla Filipović, ]]></team_members_names><keywords_hr><![CDATA[bioelektronika, optoelektronika, biofizika, nanostrukture, mikrostrukture, 3D]]></keywords_hr><keywords_en><![CDATA[bioelectronics, optoelectronics, biophysics, nanostructures, microstructures, 3D]]></keywords_en><summary_hr><![CDATA[Predlažemo osnivanje istraživačke grupe iz područja biofizike koja bi se bavila razvojem trodimenzionalno mikro- i nano-strukturiranih, bežičnih, svjetlošću upravljanih bioelektroničkih elemenata za primjenu u bio-medicinskom području. Grupu bi činili istraživači iz područja fizike i bio-medicinskog područja. Elementi bi bili pripremani na biokompatibilnim krutim i fleksibilnim supstratima, uz ciljanu namjenu kao  implantati za neurostimulaciju za primjenu u umjetnim mrežnicama, za stimulaciju perifernih živaca i autonomnog živčanog sustava i u biosenzorima za detekciju biološki važnih molekula. Optimalnu 3D geometriju elemenata i skalu veličina odredili bismo iz prvih principa numeričkim modeliranjem, nakon čega bi se elementi pripremili metodama kemijskog strukturiranja i mikrofabrikacije te odljevom u tanke slojeve polimera. Kao funkcionalni materijali koristili bi se organski poluvodiči i vodljivi polimeri, samostalno ili u hibridnoj kombinaciji sa silicijem. Opto-bioelektronički elementi bi bili karakterizirani optoelektronički i elektrofizološki. U projektu će sudjelovati znanstvene grupe iz hrvatskih znanstvenih organizacija, kao i vrhunske znanstvene grupe iz inozemstva.]]></summary_hr><summary_en><![CDATA[We propose the establishment of a research group in the field of biophysics with the aim of the development of three-dimensional micro- and nano-structured, wireless, light-controlled bioelectronic devices for use in the bio-medical field. The group would consist of researchers from the field of physics and the bio-medical field. The devices would be prepared on biocompatible rigid and flexible substrates, with targeted use as neurostimulation implants for use in the artificial retina, stimulation of peripheral nerve and autonomic nervous system, and as biosensors for the detection of biologically relevant molecules. Optimal 3D geometry of the devices and their size scale would be determined from the first principles by numerical modeling, after which the devices would be prepared by methods of chemical structuring and microfabrication, and by casting from the master to thin films of polymers. Organic semiconductors and conductive polymers, either alone or in hybrid combination with silicon would be used as the active materials. Optoelectronic and electrophysiological properties of the opto-bioelectronic devices would be characterized in detail. The project collaborators will be scientific groups from Croatian scientific organizations as well as the leading scientific groups from abroad.]]></summary_en></project><project>
<id>8495</id><title_hr><![CDATA[Fotokemija: Reakcijski mehanizmi i primjene u organskoj sintezi i biologiji]]></title_hr><title_en><![CDATA[Photochemistry: Reaction Mechanisms and Applications in Organic Synthesis and Biology]]></title_en><user_id>376</user_id><user_firstLast_name>Nikola Basaric</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-8008</code><acronim><![CDATA[PhotoApp]]></acronim><duration>15.01.2020 - 14.01.2024</duration><status>Završio</status><financ_value>132.324,51 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, Biologija, Interdisciplinarne prirodne znanosti, </scie_field_hr><scie_field_en>Chemistry, Biology, Interdisciplinary natural sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>3215, 3336, 22526, 3775, 3971, 647, 24377, 855930, 856185, 21264, </team_members_id><team_members_names><![CDATA[Marija Alešković, Margareta  Sohora, Antonija Husak, Irena Škorić, Dragana Vuk, Lidija Uzelac, Katarina Zlatić, Vilma Lovrinčević, Josip Draženović, Mladena Glavaš, ]]></team_members_names><keywords_hr><![CDATA[fotokemija, prijenos protona u pobuđenom stanju (ESIPT), kinon-metidi, fotokavezi, fotoaktivirajući lijekovi]]></keywords_hr><keywords_en><![CDATA[photochemistry, excited state intramolecular proton transfer (ESIPT), quinone methides, photocages, photoactivable drugs]]></keywords_en><summary_hr><![CDATA[Fotokemija je važno multidisciplinarno znanstveno područje zbog brojnih razvijenih primjena u suvremenim tehnologijama. Predloženi projekt usmjeren je na proučavanje nekoliko temeljnih fotokemijskih reakcija, kao i na pronalaženje primjene tih reakcija u organskoj sintezi i biologiji. Rad će obuhvatiti tri istraživačke teme: 1) prijenos protona u pobuđenom stanju s dušikovog atoma kao kiselog centra, 2) fotoheterolizu različitih anilinskih derivata za razvoj novih fotouklonjivih zaštitnih skupina u organskoj kemiji (fotocages) i 3) razvoj novih foto-tretmana raka, što će uključiti istraživanje nekoliko klasa molekula: karbazola, oligopeptida i BODIPY derivata. Istraživanje se sastoji od četiri radna paketa: A) sinteza novih molekula prekursora, B) ispitivanje fotokemijske reaktivnosti tih molekula i pronalaženje primjene fotokemijskih reakcija u organskoj sintezi, C) istraživanje mehanizama fotokemijskih reakcija spektroskopskim tehnikama i računima, te D) ispitivanje biološke aktivnosti. Predloženi projekt predstavlja prije svega temeljno istraživanje u području organske kemije. Očekuje se da će istraživačke aktivnosti dovesti do otkrića koja će povećati temeljna znanja u organskoj kemiji, fotokemiji, supramolekularnoj i medicinskoj kemiji. Osim temeljnog karaktera predloženih istraživanja, tražit ćemo primjene i unaprijediti stanje tehnike u otkrivanju novih lijekova koji se mogu aktivirati svjetlom. Očekuje se da će PhotoApp tim pronaći brojne lead molekule s antiproliferativnim djelovanjem, pružajući mogućnosti za daljnja istraživanja i potencijalni razvoj novih metodologija za liječenje raka uz minimalne nuspojave, što potencijalno utječe na dobrobit društva u cjelini.]]></summary_hr><summary_en><![CDATA[Photochemistry is an important multidisciplinary scientific field with  numerous developed applications in modern technologies. The herein proposed project is focused on the study of several fundamental photochemical reactions, as well as in finding applications of these reactions in organic synthesis and biology. The work will encompass three research topics, (1) excited state proton transfer from nitrogen atom as an acidic site, (2) photoheterolysis of different aniline derivatives for the development of new photocleavable protective groups in organic chemistry (photocages), and (3) development of novel photo-treatments of cancer, investigated for several classes of molecules: carbazoles, oligopeptides and BODIPY derivatives. The investigation comprises four working packages: (A) synthesis of new precursor molecules, (B) investigation of photochemical reactivity of these molecules and finding applications of photochemical reactions in organic synthesis, (C) investigation of photochemical reaction mechanisms by spectroscopic techniques and computations, and (D) investigation of biological activity. The proposed project will  deal with primarily fundamental research in the field of organic chemistry. Therefore, the research activities will lead to discoveries that will have an impact by increasing general knowledge in organic chemistry, photochemistry, supramolecular and medicinal chemistry. In addition to the fundamental character of the proposed investigation, we will look for the applications and go beyond the state of the art in the discovery of new photo-activable drugs. The PhotoApp team is expected to find a number of lead molecules with antiproliferative activity, providing possibilities for further research and potential development of new methodologies for treating cancer with minimal side effects, potentially benefiting the whole society in general.]]></summary_en></project><project>
<id>8496</id><title_hr><![CDATA[Profesionalizam u zdravstvu: odlučivanje u praksi i znanosti]]></title_hr><title_en><![CDATA[Professionalism in Health: Decision Making in Practice and Research]]></title_en><user_id>776</user_id><user_firstLast_name>Ana Marušić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-4882</code><acronim><![CDATA[ProDeM]]></acronim><duration>01.01.2020 - 31.12.2023</duration><status>Završio</status><financ_value>134.523,86 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Javno zdravstvo i zdravstvena zaštita, </scie_field_hr><scie_field_en>Public health and health services, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Split School of Medicine]]></institution_en><team_members_id>1016, 25966, 26405, 1418, 5258, 26438, 777, 12675, 4000, 25987, 26028, 26014, 937, 25225, 25888, 25870, 26348, 25887, 4510, 861720, 861719, 865114, 861718, 865474, 5404, 26706, 22661, </team_members_id><team_members_names><![CDATA[Lana Barać, Ivan Buljan, Danijel  Gudelj, Darko Hren, Davor Lukšić, Anita Lunić, Matko Marušić, Julije Meštrović, Damir Sapunar, Rea Ščepanović, Ružica Tokalić, Vicko Tomić, Ana  Utrobičić, Marin Viđak, Francisco Grimaldo, David Pina, Mariano Kaliterna, Pierpaolo Dondio, Livia Puljak, Jakov Matas, Antonija Mijatović, Nensi Ćaćić, Jelena Suto, Luka Ursić, Tina Poklepović Peričić, Diana Aranza, Marija Roguljić, ]]></team_members_names><keywords_hr><![CDATA[istraživanje u zdravstvu, zdravstvena praksa, odlučivanje, medicina utemeljena na dokazima, istraživačka odgovornost, znanstvena evaluacija]]></keywords_hr><keywords_en><![CDATA[health research, health practice, decision making, evidence-based medicine, research integrity, research evaluation]]></keywords_en><summary_hr><![CDATA[Predloženi projekt nastavlja istraživanja profesionalizma u zdravstvu iz prethodnog HRZZ projekta. U ovom se projektu usredotočujemo na odlučivanje kao važan čimbenik u zdravstvenoj skrbi i znanosti. Prva istraživačka tema usmjerena je na to kako pacijenti, studenti i zdravstveni stručnjaci donose odluke u praksi, utemeljene na tekstualnim sažetcima sinteze dokaza u Cochraneovim sustavnim pregledima zdravstvenih intervencija. Temeljem nalaza iz tog dijela istraživanja, testirat ćemo intervencije za poboljšanje odlučivanja u praksi. Intervencije će uključivati smjernice za kliničku praksu i mrežni alat. Druga istraživačka tema usmjerena je na donošenje odluka u istraživanju u zdravstvu u širem kontekstu znanstvene evaluacije. Istražit ćemo čimbenike koji utječu na odlučivanje o znanstvenoj čestitosti, analizom organizacijske etičke klime na medicinskom fakultetu u usporedbi s drugim fakultetima i testiranjem intervencija za poticanje razumijevanja etičkih pitanja. Kvalitativno i kvantitativno ćemo istražiti proces donošenja odluka o kvaliteti znanstvenog istraživanja u zdravstvu proučavanjem postupka evaluacije znanstvenih projekata i članaka u časopisima. U tom dijelu projekta radit ćemo s podatcima koje smo dobili od znanstvenih izdavača i agencija za financiranje znanosti. Pristup svakom specifičnom cilju istraživanja bit će utemeljen na trenutnom znanju i identifikaciji relevantnih istraživačkih pitanja; na uporabi adekvatnih istraživačkih ustroja i inovativnih metodologija, uključujući strojno učenje i računalnu jezičnu analizu; na sintezi rezultata u eksplanatorne teorije i modele; i na razvoju oruđa i diseminaciju rezultata važnih za javnu politiku i pristup zdravstvenoj skrbi. Bolje razumijevanje donošenja odluka u zdravstvenoj praksi i znanosti donijet će nove spoznaje i oruđa za poboljšanje zdravstvene skrbi i donijeti važne ekonomske i javnozdravstvene koristi.]]></summary_hr><summary_en><![CDATA[The proposed project aims to continue the research on professionalism in health from the previous CSF project. In this proposal, we focus on decision making as an important aspect of health care and research. The first research theme addresses decision making in health care practice. We will investigate the determinants of decision making by patients, students and health professionals in relation to textual summaries of evidence synthesis in Cochrane systematic reviews of health interventions. Based on the findings from this research, we will test interventions to improve making decisions in health. The interventions will include health practice guidelines and a web-based tool. The second research theme addresses decision making in health research within the wider context of research evaluation. We will explore factors that contribute to decision making about integrity in research, by analysing the ethical climate at a medical school compared to other university schools and by testing interventions to increase awareness about ethics issues. We will also study the process of decisions about quality of health research by qualitative and quantitative analysis of the peer evaluation of research grant proposals and of journal articles. This part of research will use dataset that were made available to us by granting bodies and journals. Each specific objective of the proposed research will be based on current evidence and identified knowledge gaps; it will use appropriate research design and innovative methodological tools, including machine learning and deep language analysis; it will synthesise research results into explanatory theories and models; and it will develop tools and disseminate results and experience relevant for policy and public use. Better understanding of how decisions are made in health practice and research will provide evidence and new tools to inform improving health care and bring important economic and public health benefits.]]></summary_en></project><project>
<id>8497</id><title_hr><![CDATA[Molekularno krojenje istezljivih i zacijeljivih vodljivih polimera za nosivu elektroniku]]></title_hr><title_en><![CDATA[Molecular Tailoring of Stretchable and Healable Conductive Polymers for Wearable Electronics ]]></title_en><user_id>973</user_id><user_firstLast_name>Zvonimir Katančić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2019-04</proposal_call><code>UIP-2019-04-8304</code><acronim><![CDATA[SHaPes]]></acronim><duration>01.02.2020 - 30.04.2025</duration><status>Završio</status><financ_value>261.410,84 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Kemijsko inženjerstvo, </scie_field_hr><scie_field_en>Chemical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet kemijskog inženjerstva i tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Chemical Engineering and Technology]]></institution_en><team_members_id>26951, 858331, 858333, 866838, </team_members_id><team_members_names><![CDATA[Roko Blažic, Marin Božičević, Lucija Fiket, Katarina Marković, ]]></team_members_names><keywords_hr><![CDATA[Molekularno krojenje, Nosiva elektronika, Samozacjeljivanje, Istezljivi elektrovodljivi polimeri, Radikalska polimerizacija prijenosom atoma (ATRP)]]></keywords_hr><keywords_en><![CDATA[Molecular tailoring, Wearable electronics, Self-healing, Stretchable conductive polymers, Atom transfer radical polymerization (ATRP)]]></keywords_en><summary_hr><![CDATA[Nove granice u organskoj elektronici su nosive elektronike od vodljivih polimernih materijala s visokim električnim i nalik-koži svojstvima. Takvi materijali imaju sposobnost istezanja i kretanja zajedno s ljudskim tijelom što otvara mogućnosti za razvoj istezljivih senzora za kontinuirano praćenje zdravlja. Ključno je krojenje molekularnog dizajna kako bi se dobili funkcionalni materijali koji se mogu istegnuti i zacijeliti nakon mehaničkih oštećenja. Trenutni molekularni dizajn vodljivih polimera ne može učiniti materijal istodobno rastezljivim i mehanički stabilnim uz zadržavanje sposobnosti visoke vodljivosti.Glavni cilj SHaPes-a je popuniti prazninu u znanju o novom konceptu dizajna kako bi se odgovorilo na navedeni izazov razvojem intrinzično rastezljivih i zacijeljivih vodljivih materijala koji će biti spremni za slaganje senzora za praćenje zdravlja.Ovdje predlažemo dva pristupa uvođenjem kemijskih skupina putem molekularnog krojenja za a) dinamičko nekovalentno umrežavanje i b) kovalentno umrežavanje konjugiranih graft kopolimera. Graft kopolimeri će se temeljiti na poli(3,4-etilendioksitiofenu) kao glavnom lancu i poli(akril-uretanu), te polietilen glikolu ili polikaprolaktonu kao bočnim lancima. Za postizanje postavljenog cilja koristit će se radikalska polimerizacija prijenosom atoma, kontrolirana radikalska polimerizacija kojom je moguće sintetizirati graft kopolimer s kontroliranom gustoćom i duljinom bočnih lanaca odgovornih za rastezljivost i zacijeljivost. Sintetizirani polimeri biti će inkjet tiskani na elastične podloge kako bi se dobio materijal spreman za integraciju senzora.Relevantnost i potencijalna korist SHaPes-a je razvoj znanstvene infrastrukture koja će doprinijeti modernizaciji hrvatske znanosti i tehnologije, te uključiti Hrvatsku u globalni napor za razvoj materijala sljedeće generacije za  izradu novih elektroničkih uređaja kao proizvoda visoke dodane vrijednosti.]]></summary_hr><summary_en><![CDATA[New frontiers in organic electronics are wearable electronics made of conductive polymer materials with high electrical performance and skin-like properties. Such materials have the ability to stretch and move together with the human body which opens opportunities for development of stretchable sensor for continuous health monitoring. The key is the tailoring of molecular design to obtain functional materials that can stretch and repair themselves after mechanical damage. Current molecular design of conductive polymers is unable to render material simultaneously stretchable, mechanically stable while retaining its high charge transport ability. The main goal of SHaPes is to fill the knowledge gap on new design concept to address the above challenge by developing intrinsically stretchable and healable conductive materials that will be ready for assembly of health monitoring sensors.  Herein, we propose two approaches by introducing chemical moieties through molecular tailoring to promote; a) dynamic non-covalent crosslinking and b) covalent crosslinking of the conjugated graft polymers. The graft copolymers will be based on poly(3,4-ethyilenedioxythiophene) as the backbone and poly(acrylate urethane), and polyethylene glycol or polycaprolactone as the side chains. To achieve the set goal atom transfer radical polymerization, a controlled radical polymerization able to create graft copolymer with controlled density and length of the side chains responsible for stretchability and healability, is going to be utilized. Synthesized polymers will be inkjet printed to elastic substrates to obtain material ready for sensor integration.Relevance and potential benefit of SHaPes is the development of scientific infrastructure that will contribute to modernization of Croatian science and technology and include Croatia into global effort for developing next-generation materials for fabrication of new electronic devices as products of high added value.]]></summary_en></project><project>
<id>8498</id><title_hr><![CDATA[Mapiranje parlamentarnih izbora 1848. – 1918. u Hrvatskoj]]></title_hr><title_en><![CDATA[Mapping the Parliamentary Elections 1848 – 1918 in Croatia]]></title_en><user_id>461</user_id><user_firstLast_name>Stjepan Matković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-5148</code><acronim><![CDATA[MAPPAR]]></acronim><duration>01.01.2020 - 01.06.2024</duration><status>Završio</status><financ_value>55.013,60 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Povijest, </scie_field_hr><scie_field_en>History, </scie_field_en><institution_hr><![CDATA[Hrvatski institut za povijest]]></institution_hr><institution_en><![CDATA[Croatian Institute of History]]></institution_en><team_members_id>532, 3212, 12934, 1501, 21408, 265, 6522, 26421, 26434, 2763, 26427, 6986, </team_members_id><team_members_names><![CDATA[Vedran Klaužer, Juraj Balić, Vlad Vasile Popovici, Arijana Kolak Bosnjak, Goran Ovčariček, Alexander Buczynski, Mislav Gabelica, Tomislav Kaniški, Zlatko Matijević, Marko Trogrlić, Denes Sokcsevits, Edi Miloš, ]]></team_members_names><keywords_hr><![CDATA[mapiranje, parlamentarni izbori, parlament, izbornici, Hrvatska, Vojna krajina, Habsburška Monarhija]]></keywords_hr><keywords_en><![CDATA[Mapping, Parliamentary Elections, Parliament, Electors, Croatia, Military Frontier, Habsburg Monarchy]]></keywords_en><summary_hr><![CDATA[Glavni istraživački cilj ovoga projekta jest na hrvatskom primjeru sustavno istražiti i mapirati parlamentarne izbore od uvođenja Sabora kao modernoga, jednodomnog predstavničkog tijela (1848) do sloma Austro-Ugarske (1918). Izbori su tada služili kao središnji način političkog izražavanja na nacionalnim i lokalnim razinama. Istraživanje obuhvaća područje Kraljevine Hrvatske i Slavonije, koje bi se, u određenoj mjeri, kompariralo s izbornim rezultatima u Dalmaciji, gdje se primjenjivao austrijski tip izbornoga prava s kurijalnim sustavom. U dosadašnjim historiografskim radovima nekoliko je autora pisalo o povijesti hrvatskoga parlamentarizma u sklopu multinacionalne zajednice naroda u Habsburškoj Monarhiji. U njima su, s obzirom na promatranje izbornih rezultata za Hrvatski sabor isključivo kao pokazatelja trenutačnih političkih ozračja za stvaranje stranačko-političkoga pejzaža, središnje mjesto zauzimali zbirni pregledi rezultata pojedinih saborskih izbora, a naglasak je stavljen na ispitivanje stranačkih ideologija i ustavnih pitanja. Na taj su način izostale sustavne analize izbora, koje bi ukazale na više bitnih čimbenika: izborne zakone, izborne reforme, izborne kampanje, strukture izbornih jedinica i izborništva (izborne geometrije), stranačke organizacije i biografske analize saborskih zastupnika u funkciji ispitivanja političkih elita. Osim toga, preliminarna istraživanja pokazuju da se u iznesenim pregledima pojavljuju neispravni podatci i da se nije vodilo računa o više specifičnih pojedinosti vezanih uz izborne zakone, poput dopunskih izbora ili verifikacije izbornih mandata. Stoga je zadaća ovoga projekta cjelovito sagledati izbornu povijest i ispraviti navedene propuste kako bi se dobila pouzdana baza podataka o saborskim zastupnicima i njihovim izbornim tijelima. ]]></summary_hr><summary_en><![CDATA[The main research objective of this project is to systematically investigate and map parliamentary elections on the Croatian example from the introduction of the Parliament as a modern, one chamber representative body (1848) until the dissolution of the Habsburg Monarchy (1918). In that period elections served as the basic way of political expression at national and local levels. The research covers the territory of the Kingdom of Croatia and Slavonia, which will be, to some extent, compared with election results in Dalmatia, where the Austrian type of electoral rights with a curial system was used. In previous history works, only a few authors wrote about Croatian parliamentarian history within the multinational framework of the Habsburg Monarchy. Starting from the fact that the electoral results for the Croatian Parliament were observed solely as indicators of the current political climate for the creation of a party-political landscape, the central place in the investigations thus far was a survey of the results of parliamentary elections, with an emphasis on party ideologies and constitutional issues. Up to now, there was neither a systematic analysis of the elections nor of other important factors such as: election laws, electoral reform, election campaign, electoral constituencies, manipulations (gerrymandering), and electoral structure (election geometry), party organizations and biographical analysis of parliamentary deputies as an integral part of political elites. In addition, preliminary research shows that erroneous data appear in the literature and that no more specific details of by-elections or the verification of election mandates have been taken into account. Therefore, the task of this project is to comprehensively review the electoral history and correct these omissions in order to obtain a reliable database on parliamentary representatives and their electoral bodies.]]></summary_en></project><project>
<id>8505</id><title_hr><![CDATA[Sezonska i prostorna raspodjela gena rezistencije na antibiotike u morskim mikrobnim zajednicama duž trofičkog gradijenta u srednjem Jadranu ]]></title_hr><title_en><![CDATA[Seasonal and spatial distribution of antibiotic resistance genes in marine microbial communities along a trophic gradient in central Adriatic Sea ]]></title_en><user_id>5731</user_id><user_firstLast_name>Ana Maravić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2019-04</proposal_call><code>UIP-2019-04-9778</code><acronim><![CDATA[ARGAS]]></acronim><duration>01.01.2020 - 30.06.2025</duration><status>Završio</status><financ_value>160.215,67 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, Kemija, Interdisciplinarne prirodne znanosti, </scie_field_hr><scie_field_en>Biology, Chemistry, Interdisciplinary natural sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Science]]></institution_en><team_members_id>19978, 204, 855419, </team_members_id><team_members_names><![CDATA[Ivica Šamanić, Slaven Jozić, Mia Dželalija, ]]></team_members_names><keywords_hr><![CDATA[rezistencija na antibiotike, distribucija gena, morski mikrobiom, srednji Jadran, NGS sekvenciranje ]]></keywords_hr><keywords_en><![CDATA[antibiotic resistance, gene distribution, marine microbiome, central Adriatic, NGS sequencing]]></keywords_en><summary_hr><![CDATA[Bakterijsku rezistenciju na antibiotike je Svjetska zdravstvena organizacija proglasila &#39;&#39;jednom od najvećih prijetnji globalnom zdravlju, sigurnosti hrane i razvoju danas&#39;&#39;. Prirodni okoliš, osobito vodeni, jedan je od glavnih izvora/rezervoara gena rezistencije na antibiotike (ARG). Još uvijek nam nedostaje mnogo da shvatimo sveukupni raspon ARG repertoara dostupnog u morskom okolišu i ulogu bakterijskih zajednica kao njihovih vektora prijenosa, osobito u smislu nastanka i daljnjeg širenja ARG-ova prema humanim patogenim bakterijama. Stoga, cilj nam je po prvi put sveobuhvatno i interdisciplinarno istražiti pozadinu rezistencije u planktonskim mikrobnim zajednicama duž trofičkog gradijenta srednjeg Jadrana, u odnosu na biološke i nebiološke čimbenika koji utječu na dinamiku mikrobnih zajednica kao nositelja ARG-ova, a time i raznolikosti i raspodjele ARG-ova na sezonskoj i prostornoj razini. Kombinirajući uzgojno-ovisne i najsuvremenije uzgojno-neovisne tehnike poput sekvenciranja sljedeće generacije (NGS) 16S rRNA gena procijenit ćemo prostornu i vremensku dinamiku sastava morskog mikrobioma na pet postaja u središnjem Jadranu koje se razlikuju prema razini antropogenog utjecaja, fizikalno-kemijskim i biološkim čimbenicima. Sezonske i prostorne promjene u raspodjeli ARG-ova bit će kvantificirane pomoću metode RT-PCR. Istražit će se višestruko rezistentni izolati na prisutnost drugih determinanti rezistencije i genotipizirati radi klonalne srodnosti. To, u kombinaciji s NGS sekvenciranjem nativnih plazmida koji nose svojstva rezistencije, omogućit će nove spoznaje o putevima razmjene ARG-ova u okolišu, i dalje prema taksonomski udaljenim vrstama humanih patogena. Istraživanje raznolikosti i mobilnosti okolišnog rezistoma je među ključnim čimbenicima za razumijevanje ukupne epidemiologije širenja rezistencije na antibiotike i konačnog uspjeha njegove kontrole, što je od globalnog značaja za zdravlje ljudi i okoliša.]]></summary_hr><summary_en><![CDATA[Bacterial resistance to antibiotics is declared by World Health Organization as &#39;&#39;one of the greatest threats to global health, food security and development today&#39;&#39;. Natural environments, particularly aquatic ones, are among major sources/reservoirs of antibiotic resistance genes (ARGs). We still lack much to comprehend the overall span of ARG repertoire available in marine environment as well as the role of bacterial communities as their vehicles, particularly in terms of proliferation and further dissemination of ARGs towards human pathogenic bacteria. Thus, we aim to for the first time comprehensively and interdisciplinary investigate the resistance background in planktonic microbial communities along a trophic gradient of central Adriatic Sea, regarding both biological and non-biological factors influencing the dynamics of microbial communities as ARGs carriers, and consequently, the diversity and distribution of ARGs on a seasonal and spatial scale. Combining culture-dependent and state-of-the-art culture-independent tools such as next-generation sequencing (NGS) we will assess spatial and temporal dynamics of marine microbiome composition along five sites in central Adriatic that differ by level of anthropogenic influence, physicochemical and biological factors. Seasonal and spatial changes in ARGs distribution will be quantified by RT-PCR. Multi-resistant isolates will be studied for the presence of other resistance determinants and genotyped for clonal relatedness. This, along with NGS sequencing of native plasmids carrying resistance traits will provide new insights on routes of ARGs exchange in environment, and further to taxonomically distant species of human pathogens. The research of diversity and mobility of environmental resistome is among crucial factors for the understanding of the overall epidemiology of antibiotic resistance spread and the ultimate success of its control, which is of global importance for the human and environmental health.]]></summary_en></project><project>
<id>8511</id><title_hr><![CDATA[Laserska sinteza nanočestica i primjene]]></title_hr><title_en><![CDATA[Laser synthesis of nanoparticles and applications]]></title_en><user_id>1271</user_id><user_firstLast_name>Nikša Krstulović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-6418</code><acronim><![CDATA[LaSyNanoApp]]></acronim><duration>01.02.2020 - 07.08.2024</duration><status>Završio</status><financ_value>199.073,59 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, Interdisciplinarne prirodne znanosti, </scie_field_hr><scie_field_en>Physics, Interdisciplinary natural sciences, </scie_field_en><institution_hr><![CDATA[Institut za fiziku]]></institution_hr><institution_en><![CDATA[Institute of Physics in Zagreb]]></institution_en><team_members_id>25721, 19143, 23301, 23300, 25965, 6722, 22458, 6683, 6748, 866588, 865330, 868673, </team_members_id><team_members_names><![CDATA[Julio Car, Mario  Ščetar, Nino Dimitrov, Ivona Vidić Štrac, Bernarda Damianić, SANJA ERCEGOVIĆ RAŽIĆ, Jelena Peran, Lucija Krce, Ivica Aviani, Dejan Maletić, Rafaela Radičić, Karolina Pietrzak, ]]></team_members_names><keywords_hr><![CDATA[plazmene tehnologije, obrade plazmom, laserska sinteza nanočestica, metalne nanočestice, dvokomponentne nanočestice, metal oksidne nanočestice, atmosf]]></keywords_hr><keywords_en><![CDATA[plasma technology, plasma processing, laser synthesis of nanoparticles, metallic nanoparticles, two-component nanoparticles, metal-oxide nanoparticles]]></keywords_en><summary_hr><![CDATA[Plazmene tehnologije poprimaju sve veće zanimanje i značenje u razvoju naprednih materijala nove generacije zbog svojih jedinstvenih svojstava, široke primjene i učinkovitosti djelovanja. Obrada materijala pomoću plazme sve se više koristi u industrijskim, tehnoloških i medicinskim primjenama. Ovaj projekt se zasniva na laserskoj inovativnoj sintezi koloidnih otopina nanočestica, obradi polimera pomoću atmosferskog plazmenog mlaza i njihovim primjenama u razvoju novih kompozitnih materijala. Laserska sinteza nanočestica bazira se na procesu laserske ablacije metalnih meta u tekućinama , a i ne onečišćuje okoliš (&#39;green&#39; tehnika sinteze) jer nema uporabe kemikalija i nusprodukata kemijskih reakcija. Nanočestice od interesa su metali, metalni oksidi i dvokomponentne nanočestice. Nanočestice će se koristiti za razvoj fotokatalize i za inkorporaciju u polimere i srodne materijale (tekstilne polimerne materijale i polimere relevantne za pakiranje hrane). Inkorporaciju nanočestica u polimerne materijale bit će potpomognuta hladnim atmosferskim plazmenim mlazom. Ovo je vrsta neravnotežne i netermalne plazme pa nema oštećenja za termoosjetljive materijale, ali je istovremeno vrlo reaktivna zbog prisutnosti radikala. Cilj projekta je dobiti polimerne materijale za pakiranje hrane s boljim barijernim svojstvima i antimikrobnom aktivnošću i malom stopom curenja nanočestica iz materijala, tekstilne polimerne materijale s boljom UV zaštitom i boljom antimikrobnom učinkovitošću kao i unaprijediti proces fotokatalize primjenom specijalno dizajniranih nanočestica dobivenih razvojem inovativne tehnike laserske sinteze nanočestica u tekućinama. Rezultati projekta mogu imati utjecaja na razvoj materijala relevantnih za pakiranje hrane i umjetnog tekstila.Projekt će jednim svojim dijelom biti posvećen obrazovanju dodiplomskih i doktorskih studenata kao i poslijedoktoranada što svakako doprinosi razvoju njihovih karijera.]]></summary_hr><summary_en><![CDATA[Plasma technologies are taking attention in the development of emerging advanced materials of new generation due of its unique properties, broadness of applications and effectiveness of treatment. Plasma processing of materials is increasingly used in industrial, technological and medical applications. This project is based on laser innovative synthesis of colloidal nanoparticle, treatment of polymers with atmospheric pressure plasma jet (APPJ) and their applications in development of new composite materials. Laser synthesis of nanoparticles is based on a process of laser ablation of metallic targets in liquids. This technique is known as &#39;green&#39; synthesis method because there are no chemicals or chemical byproducts involved in synthesis. Nanoparticles of interest are metallic, metal-oxides and two-component nanoparticles. Nanoparticles will be used for development of photocatalysis and for incorporation in polymers and polymer related materials (textile polymers and food packaging polymers). Incorporation of nanoparticles into materials will be assisted by APPJ. This is a non-equilibrium, non-thermal type of plasma  so there is no thermal damage on thermosensitive materials, but this type of plasma is very reactive due to presence of reactive chemical species. The goal of the project is to fabricate polymer food packaging materials with improved barrier properties, better antimicrobial activity and low rate of nanoparticles leaching and textile materials with better UV protection and better anti-microbial activity and to improve the photocatalysis process by application of specially designed nanoparticles fabricated from development of innovative technique of laser synthesis of nanoparticles in liquids. Project results may impact the development of materials related to food packaging and textiles.Project will be in part devoted to education and training of the graduate and PhD students and postdocs, certainly promoting career development of young scientists.]]></summary_en></project><project>
<id>8519</id><title_hr><![CDATA[Procjena stanja i obnova postojećih građevina -  Razvoj suvremenih metoda za zidane i drvene konstrukcije]]></title_hr><title_en><![CDATA[Assessment and rehabilitation of existing structures - Development of contemporary methods for masonry and timber structures]]></title_en><user_id>19909</user_id><user_firstLast_name>Mislav Stepinac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2019-04</proposal_call><code>UIP-2019-04-3749</code><acronim><![CDATA[ARES]]></acronim><duration>09.01.2020 - 08.01.2025</duration><status>Završio</status><financ_value>180.913,63 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Građevinarstvo, Temeljne tehničke znanosti, </scie_field_hr><scie_field_en>Civil engineering, Basic engineering sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Građevinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Civil Engineering]]></institution_en><team_members_id>26415, 26414, 26417, 26418, 20244, 26664, 29374, 861469, 865235, </team_members_id><team_members_names><![CDATA[Tvrtko Renić, Ivan Hafner, Janko Košćak, Nikola Perković, Jure Barbalić, Robert Jockwer, Luka Lulić, Karlo Ožić, Antonela Moretić, ]]></team_members_names><keywords_hr><![CDATA[ocjena, ziđe, drvo, pouzdanost, obnova, konstrukcije, metode]]></keywords_hr><keywords_en><![CDATA[assessment, masonry, timber, reliabilty, rehabilitation, structures, methods]]></keywords_en><summary_hr><![CDATA[Više od 75% hrvatskog građevinskog fonda starije je od 30 godina, što predstavlja vrijeme kod kojeg je, za većinu objekata, potrebna renovacija ili rekonstrukcija. Više od 40% zgrada starije je od 50 godina što bi značilo da je uporabni vijek tih zgrada već istekao. Procjena stanja postojećih konstrukcija temelji se na identifikaciji, lokalizaciji i ocjeni propadanja i oštećenja konstrukcije. Nalazi procjene stanja temeljeni su na postupcima projektiranja novih konstrukcija i planiranje zahvata obično sugerira pojačanje konstrukcije. Trenutna praksa ne može se smatrati prikladnom za sigurnu odluku o pouzdanosti konstrukcije. Determinističke metode za vrjednovanje postojećih konstrukcija dopuštaju jednostavnu procjenu, ali pate od velikih faktora sigurnosti. Kod procjene stanja na razini pouzdanosti izbjegava se otkazivanje i nepotrebno rušenje konstrukcije, a rezultat su sigurnije konstrukcije i bolje korištenje resursa. Rješavanjem problema kao što je učinkovito određivanje svojstava konstrukcije i materijala, određivanje utjecaja opterećenja u proteklom vremenu te njegovog trajanja na ponašanje konstrukcije može biti vrijedno i od velike pomoći za projektante, kao i za istraživače i znanstvenike koji se bave procjenom stanja zidanih i drvenih konstrukcija. Cilj ovog istraživačkog projekta je istražiti ulogu procjene stanja na analizu pouzdanosti postojećih konstrukcija. Projekt će se baviti postojećim zidanim i drvenim konstrukcijama kako bi utvrdio prednosti procjene stanja u pogledu ekonomičnosti i sigurnosti konstrukcija. U projektu će se vrjednovati metode “nadogradnje” podataka za primjenu procjene stanja te će se proučavati ponašanje konstrukcija ovisno o vremenu i utjecajima uvjeta okoliša. Izradit će se smjernice s integriranim metodama pouzdanosti za projektiranje, procjenu i obnovu stanja postojećih konstrukcija te će one biti najznačajniji rezultat projekta. Rezultati projekta imat će značajan utjecaj na međunarodne norme za projektiranje konstrukcija.]]></summary_hr><summary_en><![CDATA[More than 75% of the building stock in Croatia is older than 30 years, an age often requiring renovation or modification of buildings. In addition, more than 40% of the building stock is older than 50 years meaning that the service life of the structures is expired. The assessment of existing structures focuses mainly on the identification, localization and evaluation of deterioration, decay and damage. The diagnoses are based on the design procedures of new structures and the planning of interventions. The current practice might not be considered suitable to facilitate confident decisions about the reliability of structures. Deterministic methods for the evaluation of existing structures allow for an easy evaluation but suffer from large safety factors. Reliably assessing structures avoids failures and unnecessary decommissioning, and leads to safer structures and better use of resources. Solving the issues like the determination of structural & material properties, quantification of the impact of loading history and load duration on structural performance can be valuable and precious help for designers as well as for researchers and scholars dealing with the assessment of masonry and timber structures. The aim of this research project is to study the role of assessment on the reliability analysis of existing structures. The project focuses on existing masonry and timber structures to evaluate the benefits of assessment with regard to the economy and safety of structures. Also, the project will evaluate updating methods for the application of the assessment & verification of structures and consideration of time-dependent behaviour & the influence of environmental conditions. Design guidelines and integration of reliability methods in assessment and rehabilitation of existing structures will be the main benefit of the project. The results of the project will have a decisive impact on international codes regarding structural engineering.]]></summary_en></project><project>
<id>8522</id><title_hr><![CDATA[Diskografska industrija u Hrvatskoj od 1927. do kraja 1950-ih]]></title_hr><title_en><![CDATA[The record industry in Croatia from 1927 to the end of the 1950s]]></title_en><user_id>143</user_id><user_firstLast_name>Naila Ceribašić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-4175</code><acronim><![CDATA[DISKOGRAF]]></acronim><duration>18.02.2020 - 17.02.2024</duration><status>Završio</status><financ_value>51.362,67 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Znanost o umjetnosti, Povijest, Etnologija i antropologija, </scie_field_hr><scie_field_en>Arts, History, Ethnology and anthropology, </scie_field_en><institution_hr><![CDATA[Institut za etnologiju i folkloristiku]]></institution_hr><institution_en><![CDATA[Institute of Ethnology and Folklore Research in Zagreb]]></institution_en><team_members_id>27008, 12631, 26268, 20042, 26272, 22615, 856130, </team_members_id><team_members_names><![CDATA[Nada Bezić, Joško Ćaleta, Tanja Halužan, Irena Miholić, Željka Radovinović, Jelka Vukobratović, Dora Dunatov, ]]></team_members_names><keywords_hr><![CDATA[glazba, diskografska industrija, Zagreb, Hrvatska, glazba u izvedbi, diskografski filtar, nacionalna povijest, baština, tržište, (etno)muzikologija]]></keywords_hr><keywords_en><![CDATA[music, record industry, Zagreb, Croatia, music in performance, record filter, national history, heritage, market, (ethno)musicology]]></keywords_en><summary_hr><![CDATA[Predloženi će projekt biti prvim primjerom sustavnoga znanstvenog pristupa temi diskografske industrije u Hrvatskoj. Usredotočit će se na razdoblje od 1927. do kraja 1950-ih, obuhvaćajući time doba šelak ploča u produkciji triju diskografskih tvrtki sa sjedištem u Zagrebu (Edison Bell Penkala, Elektroton i Jugoton). Osim ugroženosti gramofonskih ploča kao primarnih izvora te manjka pouzdane dokumentacije o njima, poticaj za ovaj projekt dolazi i iz razumijevanja diskografije i njezine podupiruće industrije kao konstitutivnih za glazbu i glazbeni život s obzirom na dva ključna aspekta: samu glazbu koja se ostvaruje u izvedbi i/ili kao izvedba te diskografske “filtre” koji kroz odabir glazbenog repertoara i interpreta, produkcijske mogućnosti i težnje, uvjete rada glazbenika i načine tržišnog plasmana iscrtavaju ne samo dinamiku, hijerarhije i tendencije u glazbi i glazbenom životu nego i mikropovijest hrvatskog društva i kulture razmatranih razdoblja. Pet je osnovnih ciljeva projekta: izraditi temeljitu i sveobuhvatnu bazu podataka diskografskih izdanja triju zagrebačkih diskografskih tvrtki; dati znanstveno utemeljen uvid u poetiku, politiku i ekonomiju diskografske industrije razmatranih razdoblja; podrobno, u formi studija slučaja, istražiti pojedine odabrane aspekte diskografske industrije; unaprijediti domaću znanost o glazbi; pridonijeti jačanju svijesti u javnosti o diskografskim izdanjima kao važnom dijelu kulturne baštine. Projekt će rezultirati znanstvenim člancima (oko 16), zajedničkom knjigom (s oko 12 poglavlja), doktorskom disertacijom, individualnim i skupnim izlaganja na konferencijama (23) i konferencijom u vlastitoj organizaciji, elektronskom bazom podataka Hrvatska e-diskografija, slušaonicama starih ploča uz debatni klub (četiri puta godišnje) i prilozima iz tematike projekta priređenima za Hrvatski radio (triput godišnje).]]></summary_hr><summary_en><![CDATA[The proposed project will be the first instance of a systematic scholarly approach to the topic of record industry in Croatia. It will focus on the period from 1927 until the end of 1950s, thus covering the era of shellac records produced by three record companies based in Zagreb (Edison Bell Penkala, Elektroton and Jugoton). In addition to the endangerment of gramophone records as primary sources and the lack of reliable documentation on them, the impetus for this project comes from understanding discography and its supporting industry as constituent elements of music and musical life in view of two key aspects: the music itself, realized in/as performance, and the record “filters” which – through the choice of musical repertoire and interpreters, production possibilities and aspirations, musicians’ working conditions and ways of market placement – draw out not only the broader dynamics, hierarchy and tendencies in music and musical life but also the microhistory of Croatian society and culture in the periods in question. There are five main project objectives: to create a thorough and comprehensive database of record releases made by the three companies; to provide a scholarly based insight into the poetics, politics and economics of the record industry during the periods in question; to explore selected aspects of the record industry in detail in the form of case studies; to improve the (ethno)musicological studies in Croatia; to contribute to the public awareness of record releases as an important part of cultural heritage. The project will result in scholarly articles (about 16), a joint book (with about 12 chapters), a PhD thesis, individual and group presentations at conferences (23) and a conference in our organization, the digital database Hrvatska e-diskografija (Croatian e-discography), the old record listening sessions and the debate club (four times a year), and the features on the project topics prepared for the Croatian Radio (three times a year).]]></summary_en></project><project>
<id>8524</id><title_hr><![CDATA[Razvoj funkcionalnih biogoriva i (bio)aditiva te ispitivanje primjenskih svojstava mješavina s mineralnim gorivima]]></title_hr><title_en><![CDATA[Development of functional biofuels and (bio)additives and characterization of blends with mineral fuels ]]></title_en><user_id>1337</user_id><user_firstLast_name>Fabio Faraguna</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2019-04</proposal_call><code>UIP-2019-04-5242</code><acronim><![CDATA[FunBioFA]]></acronim><duration>04.01.2020 - 03.01.2025</duration><status>Završio</status><financ_value>172.900,66 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Temeljne tehničke znanosti, Kemijsko inženjerstvo, Strojarstvo, </scie_field_hr><scie_field_en>Basic engineering sciences, Chemical engineering, Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet kemijskog inženjerstva i tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Chemical Engineering and Technology]]></institution_en><team_members_id>13461, 23206, 26753, 858342, 858335, </team_members_id><team_members_names><![CDATA[Petar Ilinčić, Lucija Konjević, Dijana Blažek, Mia Gotovuša, Ivan Pucko, ]]></team_members_names><keywords_hr><![CDATA[Biogorivo, Bioaditiv, Membransko pročišćavanje, Motorni test, Ispušni plinovi, Mješavine goriva i biogoriva, Karakterizacija goriva, EN 590, EN 228, E]]></keywords_hr><keywords_en><![CDATA[Biofuel, Bioadditives, Membrane purification, Engine combustion tests, Exhaust gas, Fuel and Biofuel blends, Fuel characterization, EN 590, EN 228, EN]]></keywords_en><summary_hr><![CDATA[Fosilna goriva kao primarni izvori energije imaju značajan utjecaj na okoliš i pridonose globalnom zatopljenju. U okvirima svjetske klimatsko-energetske politike teži se zamjeni upotrebe fosilnih goriva s obnovljivim izvorima energije kao što su biomasa, sunce, vjetar i geotermalna energija. Trenutno je biomasa četvrti najzastupljeniji energetski resurs na svijetu, odmah nakon nafte, plina i ugljena. Biomasa se može pretvoriti u sve glavne energetske nositelje (npr. električna struja, toplina) kao i široku paletu kemikalija i materijala koji se trenutno proizvode iz fosilnih goriva. Sinergija perspektive znanosti i industrije u stvaranju inovativnih novih materijala na bio-osnovi, kao što su funkcionalna biogoriva i bioaditivi, ključni je korak za učinkoviti prijelaz iz trenutnog razdoblja, gdje su fosilni izvori osnova energije i kemikalija, u razdoblje biogoriva i biokemikalija iz obnovljivih izvora. U ovom projektu razvit će se nova funkcionalna biogoriva, bioaditivi i polimerni aditivi te osmisliti nove i unaprijediti postojeće metode pročišćavanja biokemikalija membranskim procesima. Ispitat će se primjenska svojstva dvokomponentnih (mineralno gorivo, biogorivo), trokomponentnih (mineralno gorivo, biogorivo, alkohol) i formuliranih mješavina s (bio)aditivima prema standardima i normama za goriva i biogoriva. Nakon analiza sljedit će ispitivanje karakteristika izgaranja u motoru te analiza ispušnih plinova. Cilj ovog projekta je od otpadne sirovine (otpadno ulje, životinjska mast) primjenom kemijskih i kemijsko inženjerskih znanja razviti proces sinteze/pročišćavanja koji će za produkt imati visokovrijednu biokemikaliju u obliku funkcionalnog biogoriva ili bioaditiva. Za vrijeme trajanja projekta, troje mladih znanstvenika (dvoje iz naftne industrije) steći će napredna znanja u području sinteze, pročišćavanja i analize biogoriva i bioaditiva što će moći primijeniti izravno u industriji tokom razvoja novih procesa i proizvoda.]]></summary_hr><summary_en><![CDATA[Fossil fuels as primary sources of energy have a significant impact on the environment and contribute to global warming. Within the framework of the global climate and energy policy, the replacement of fossil fuels with renewable energy sources such as biomass, solar, wind and geothermal energy is sought. At present, biomass, immediately after oil, gas and coal, is the fourth most abundant energy resource in the world. Biomass can be converted into all major energy carriers (e.g. electricity, heat) as well as a wide diversity of chemicals and materials that are currently produced from fossil fuels. In the field of sustainable energy, combining science and industry perspectives to create innovative new biobased materials, like functional biofuels and bioadditives, is critical to efficiently cope with the current period of transition from fossil based energy, chemicals and materials, to renewable energy, biochemicals and biomaterials. During this project, new functional biofuels, bioadditives and polymer additives will be developed and their purification using membrane process will be investigated. Application properties (according to standards for fuels and biofuels) of new biofuels, two-component (mineral fuel, biofuel), three-component (mineral fuel, biofuel, alcohol) blends and formulated mixtures with (bio)additives will be determined as well as their engine combustion characteristics and exhaust gas analysis. The aim of this project is to develop a synthesis / purification process which will produce a high value biochemical in the form of a functional biofuel or a bioadditive from waste material (waste oil, animal fat), using chemical and chemical engineering expertise. During the project, three young scientists (two from the industry) will acquire advanced knowledge in the field of synthesis, purification and analysis of biofuels and bioadditives, which they will be able to apply directly for development of new processes and products in the industry.]]></summary_en></project><project>
<id>8526</id><title_hr><![CDATA[Moderne europske diplomacije i istočnojadranski prostor]]></title_hr><title_en><![CDATA[Modern European Diplomacies and the Eastern Adriatic]]></title_en><user_id>26036</user_id><user_firstLast_name>Jadranka Neralić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-7244</code><acronim><![CDATA[MEDEA]]></acronim><duration>01.01.2020 - 31.12.2023</duration><status>Završio</status><financ_value>74.059,33 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Povijest, Filologija, Povijest umjetnosti, Religijske znanosti, Interdisciplinarne humanističke znanosti, </scie_field_hr><scie_field_en>History, Philology, Art history, Religion, Interdisciplinary humanities, </scie_field_en><institution_hr><![CDATA[Hrvatski institut za povijest]]></institution_hr><institution_en><![CDATA[Croatian Institute of History]]></institution_en><team_members_id>25741, 26156, 26305, 5524, 26078, 7383, 2834, </team_members_id><team_members_names><![CDATA[Valerija Macan Lukavečki, MASSIMILIANO VALENTE, Zdenko Dundović, Nikša Varezić, Andreas Gottsmann, Luka Špoljarić, Stipe Kljaić, ]]></team_members_names><keywords_hr><![CDATA[Renesansna Rimska Kurija, diplomatsko pregovaranje, Apostolske Nuncijature, Dalmacija, arhivski izvori, ranomoderna povijest, suvremena povijest]]></keywords_hr><keywords_en><![CDATA[Renaissance Roman Curia, diplomatic negotiation, Apostolic Nunciature, Dalmatia, Archival sources, Early Modern History, Contemporary History,]]></keywords_en><summary_hr><![CDATA[Prostor istočne jadranske obale i njegova zaleđa tijekom raznih povijesnih razdoblja bio je, zbog specifičnoga zemljopisnoga smještaja i upućenosti na posredničku trgovinu i mediteransku plovidbu, protagonist kompleksnih odnosa i politika brojnih država. Na njemu su svoje interese tražile i nalazile brojne velesile poput Mletačke Republike, Ugarskoga, Španjolskoga i Francuskoga Kraljevstva, Habsburške Monarhije, Ruskoga i Otomanskog Carstva. Svojim su dinamičnim međusobnim odnosima oblikovale gospodarsku i političku sliku Jadrana unutar mediteranskog konteksta i geopolitičkog okvira jugoistočne Europe. Jadranski je prostor oduvijek ovisio i o zaštiti političkih moćnika, a u vremenskim je okvirima ovoga projekta, od početka 15. stoljeća to Papinska Država. Ona je početkom renesansne izrasla u najsofisticiraniju europsku administraciju s najboljom mrežom diplomatskih predstavništava koje papa, poput suverenog vladara samostalno kontrolira uz pomoć učinkovite administrativne službe pri Državnom Tajništvu. Kao što Papa svoje najvjernije suradnike, koji uživaju njegovo neograničeno povjerenje, odašilje na vladarske dvorove širom Italije, Europe i svijeta, tako i vladari svoje diplomate upućuju na papin dvoru u Rimu. Svi su oni u najkraćem vremenu dobivali dragocjene informacije koje su olakšavale diplomatsko pregovaranje i brzo donošenje političkih odluka. Dakako, premda se čini kako su ispred ostalih europskih i svjetskih diplomacija, papine su aktivnosti sa njima svakako usklađene i unaprijed dogovorene. Ovim ćemo projektom, kroz mikrohistorijski pristup, proučavanjem transkulturalnih dodira na širem europskom prostoru, životopisa, karijera i intelektualnog svjetonazora diplomata sa prostora Dalmacije u papinoj službi,donijeti svježi pogled na povijesti diplomacije.]]></summary_hr><summary_en><![CDATA[Eastern Adriatic and its hinterland have for centuries been important protagonists of complex relations and policies of different states, thanks to their specific geographical position focused on mediatory trade and Mediterranean navigation. Great powers like the Venetian Republic, Hungarian, Spanish and French Kingdoms, Habsburg Monarchy as well as the Russian and Ottoman Empires found and constructed their economic, political, strategic or cultural interests there. Dynamic mutual networking inevitably defined political and economic Adriatic scene within a wider Mediterranean and south-eastern European context. However, Adriatic region has always depended on protection of various political powers, and within the timeframe proposed by this project research it was the Papal State. It grew into a sophisticated administration with the best organised diplomatic network at the very beginning of Renaissance, and continued to be a model to other European Courts for centuries after. The Sovereign Pontiff stood at the top of this network and controlled it, helped by the efficient Secretary of State administrative department. He would send his most trusted officials to Italian and European princes&#39; Courts; likewise, their diplomats were appointed to the Papal Court in Rome. Soon, the Roman Papal Curia became the best informed European Court with the constant flow of information which made the negotiations and political decision making fast and easier. Although it seems that the papal diplomacy stood well in front of its time and paved the way to others, the Pope&#39;s activities have evidently always been agreed and coordinated beforehand. This project will explore how micro-historical approach can yield a new kind of diplomatic history, through the study and reconstruction of transcultural encounters outside national frameworks, life, careers and intellectual worldview of Dalmatian born diplomats in Papal service through centuries.]]></summary_en></project><project>
<id>8527</id><title_hr><![CDATA[Utjecaj poreza i socijalnih naknada na raspodjelu dohotka i ekonomsku efikasnost]]></title_hr><title_en><![CDATA[Impact of taxes and benefits on income distribution and economic efficiency]]></title_en><user_id>842</user_id><user_firstLast_name>Ivica Urban</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-9924</code><acronim><![CDATA[ITBIDEE]]></acronim><duration>15.01.2020 - 14.06.2024</duration><status>Završio</status><financ_value>88.526,11 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, </scie_field_hr><scie_field_en>Economy, </scie_field_en><institution_hr><![CDATA[Institut za javne financije]]></institution_hr><institution_en><![CDATA[Institute of Public Finance]]></institution_en><team_members_id>12574, 21291, 20002, 25958, 12420, 22694, </team_members_id><team_members_names><![CDATA[Slavko Bezeredi, Martina Pezer, Ivica Rubil, Marko Ledic, Chrysa  Leventi, Nora Mustać, ]]></team_members_names><keywords_hr><![CDATA[mikrosimulacija, porezi, socijalne naknade, nejednakost dohotka, pravednost, efikasnost, optimalno oporezivanje]]></keywords_hr><keywords_en><![CDATA[microsimulation, taxes, social benefits, income inequality, equity, efficiency, optimal taxation]]></keywords_en><summary_hr><![CDATA[Ekonomska analiza nije sveobuhvatna ako se istodobno ne bavi ekonomskom efikasnošću i pravednošću u raspodjeli. Na tom se uporištu zasniva ovaj projekt, koji se bavi utjecajem poreza i socijalnih naknada na raspodjelu dohotka i ekonomsku efikasnost. Porezi i socijalne naknade imaju preraspodjelnu funkciju, ali istodobno utječu na alokaciju proizvodnih faktora i finalnih proizvoda, odnosno na efikasnost. Stoga pri dizajniranju i reformiranju poreza i socijalnih naknada treba voditi računa o pravednosti u raspodjeli i o efikasnosti. Projekt je empirijski orijentiran, a svrha mu je dvojaka. Prva svrha je unaprijediti metodologiju empirijske analize utjecaja poreza i socijalnih naknada na raspodjelu dohotka i ekonomsku efikasnost: (1) proširenje miCROmod-a uključivanjem modula za simulaciju neizravnih poreza; (2) povećanje vjerodostojnosti anketnih podataka o distribuciji dohotka u smislu da najviši dohoci u uzorku na reprezentativan način odražavaju one u populaciji; (3) promjena načina određivanja doprinosa neizravnih poreza efektivnoj poreznoj stopi. Druga svrha projekta je provesti nekoliko empirijskih analiza: razine i kretanja dohodovne nejednakosti; utjecaja izravnih i neizravnih poreza i socijalnih naknada na nejednakost, siromaštvo i isplativost rada; procjenu optimalnog oporezivanja najviših dohodaka; procjenu društvenih preferencija prema preraspodjeli dohotka. Unaprjeđenjem odabranih aspekata empirijske analize u ovom području doprinosi se međunarodnoj akademskoj literaturi na način da se uvode novine koje mogu utjecati na rezultate analiza koje provode brojni istraživači, a novi rezultati mogu korigirati neke dosadašnje spoznaje. Empirijska istraživanja za Hrvatsku ponudit će rezultate iskoristive pri promišljanju često zazivanih reformi sustava poreza i socijalnih naknada. Projektom se također pridonosi uspostavi kulture javne rasprave o poželjnosti i adekvatnosti politika na temelju znanstvenih rezultata.]]></summary_hr><summary_en><![CDATA[Economic analysis is not comprehensive if it does not deal both with economic efficiency and equity. This is the basic postulate of the project, which deals with the impact of taxes and social benefits on income distribution and economic efficiency. Taxes and social benefits have a redistributive function, but at the same time they affect the allocation of production factors and final products, i.e., the efficiency. Thus, in designing and reforming taxes and social benefits it is essential to take into account both equity and efficiency. The project is empirically oriented and its purpose is two-fold. The first purpose is to improve the methods of empirical analysis in this field of research: (1) to upgrade the miCROmod by the inclusion of the module for simulation of indirect taxes; (2) to improve the credibility of the survey data on income distribution, in the sense that the top incomes in the sample reflect in a representative way those in the population; (3) to change the way of determining the contribution of indirect taxes to the effective tax rate. The second purpose of the project is to conduct several empirical analyses: of the levels and trends of income inequality; of the impact of direct and indirect taxes and social benefits on inequality, poverty and work incentives; assessing the optimal taxation of the top incomes; estimating the social preferences towards redistribution of income. The improvements of selected aspects of empirical analysis in this area contributes to international academic literature by introducing novelties that can affect the results of analyses carried out by numerous researchers; new findings can bring changes to the current knowledge. Empirical research for Croatia will offer results usable in considering the often invoked reforms of the tax-benefit system. The project also contributes to a culture of evidence-based public debate on the desirability and adequacy of public policies.]]></summary_en></project><project>
<id>8529</id><title_hr><![CDATA[Nelokalni mehanički modeli nanogreda]]></title_hr><title_en><![CDATA[Nonlocal mechanical models of nanobeams]]></title_en><user_id>3419</user_id><user_firstLast_name>Marko Čanađija</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-4703</code><acronim><![CDATA[nonNano]]></acronim><duration>01.02.2020 - 31.05.2024</duration><status>Završio</status><financ_value>94.750,81 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Temeljne tehničke znanosti, Strojarstvo, Interdisciplinarne tehničke znanosti, </scie_field_hr><scie_field_en>Basic engineering sciences, Mechnical engineering, Interdisciplinary technological sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Tehnički fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Engineering]]></institution_en><team_members_id>26140, 3323, 3330, 13118, 13331, 29257, 858399, </team_members_id><team_members_names><![CDATA[Stefan Ivić, Marino Brčić, Neven Munjas, Ante Skoblar, Nikola Anđelić, Martin Zlatić, Valentina Košmerl, ]]></team_members_names><keywords_hr><![CDATA[nanogrede, nelokalna mehanika, nanosenzori, konačni elementi, integracijska formulacija, ugljične nanocijevi]]></keywords_hr><keywords_en><![CDATA[nanobeams, nonlocal mechanics, nanosensors, finite elements, integral formulation, carbon nanotubes]]></keywords_en><summary_hr><![CDATA[Predloženim istraživanjem razvit će se napredni nelokalni modeli nanogreda, a koji će biti prikladni za provođenje realističnih simulacija mehaničkog ponašanja nanostruktura. Naime, velika većina rezultata predstavljenih u literaturi uključuje određenje manjkavosti. U tom smislu valja istaći dva problema. Često korištena nelokalna gredna formulacija temeljena na gradijentnim metodama daje paradoksalne rezultate u nekim osnovnim problemima. Drugi je problem povezan s mehaničkim značajkama koje su potrebne radi dobivanja rezultata usporedivih s eksperimentima odnosno simulacijama provedenim pomoću molekularne dinamike. Pritom se kao najvažnija mehanička značajka može istaći nelokalni parametar. Točna vrijednost nelokalnog parametra za pojedine materijale uključuje mnoštvo nesigurnosti. Da bi se nadišlo gore opisane paradokse, koristit će se integracijska formulacija temeljena na naprezanjima. Ovo je novi i obećavajući pristup koji nema spomenute poteškoće. Što se pak tiče realističnog mehaničkog ponašanja, da bi se postigao takav cilj mora se uzeti u obzir i diskretnu prirodu nanostruktura. U tom smislu, izotermni procesi deformiranja nanogreda predstavljat će ishodišnu točku, no fokus će biti na neizotermičim problemima. U prvom redu, u tom kontekstu razmatrat će se važna proširenja na dinamičko ponašanje, kao i na kompozitne nanogrede. Razvijene formulacije bit će iskorištene za razvoj novog nelokalnog grednog konačnog elementa koji će biti ugrađen u softver za analizu konačnim elementima Simulia/Abaqus. Novi konačni element omogućit će provođenje niza simulacija s ciljem dobivanja topološki optimalnih struktura s ciljanim značajkama.]]></summary_hr><summary_en><![CDATA[The proposal at hand aims to develop advanced nonlocal models of nanobeams suitable for more realistic simulation of mechanical behavior of nanostructures. Motivation for this research arises from several shortcomings in majority of results presented in the literature. Two of them have to be pointed out. A widely used gradient based beam nonlocal formulations are prone to paradoxical results if applied to some of basic bending problems. The other problem is related to mechanical properties that are needed in order to obtain similar results like those obtained experimentally or by molecular dynamics simulations. The most important mechanical property is the nonlocal parameter, but its precise value for a certain material still encompasses a lot of uncertainties. In order to overcome mentioned paradoxes, the stress-driven integral formulation will be used. This is a novel and promising approach, not suffering from above described problems. As for the realistic mechanical behavior, in order to reach such a goal, the discrete nature of nanostructures must be accounted for. Although isothermal deformation of nanobeams will be the starting point, the focus will be on the nonisothermal processes. In particular, those will include important extensions to dynamical effects, as well as to composite materials. The formulations obtained in such manner will be used to develop a novel nonlocal beam finite element that will be implemented into finite element software Simulia/Abaqus. With new finite element, a series of simulations will be performed in order to obtain topologically optimal structures with tailored properties.]]></summary_en></project><project>
<id>8530</id><title_hr><![CDATA[Razumijevanje (eko)toksikološke uloge odabranih SLC i MATE transportnih proteina zebrice (Danio rerio) korištenjem metoda funkcionalne genomike]]></title_hr><title_en><![CDATA[Understanding the (eco)toxicological role of selected SLC and MATE transport proteins in zebrafish (Danio rerio) using functional genomics tools]]></title_en><user_id>986</user_id><user_firstLast_name>Tvrtko Smital</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-1147</code><acronim><![CDATA[DANIOTRANS]]></acronim><duration>01.03.2020 - 29.06.2024</duration><status>Završio</status><financ_value>125.688,50 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, Interdisciplinarne prirodne znanosti, </scie_field_hr><scie_field_en>Biology, Interdisciplinary natural sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>3923, 1050, 17738, 657, 951, 27233, </team_members_id><team_members_names><![CDATA[Jovica Lončar, Ivan Mihaljević, Jelena Dragojević, Nikola Maraković, Dean Karaica, Ivan Antičević, ]]></team_members_names><keywords_hr><![CDATA[uptake i efflux membranski transportni proteini, (eko)toksikološka relevantnost, zebrica (Danio rerio), funkcionalna genomika, CRISPR/Cas9]]></keywords_hr><keywords_en><![CDATA[uptake and efflux membrane transporters, (eco)toxicological relevance, zebrafish (Danio rerio), functional genomics, CRISPR/Cas9]]></keywords_en><summary_hr><![CDATA[Polispecifični membranski transportni proteini predstavljaju integralni dio kompleksne stanične obrane u sisavaca, a dva tipa transportera pri tome su od osobite toksikološke važnosti: tzv. uptake transporteri i efflux transporteri. Analogni stanični obrambeni sustav uključen je u procesiranje endo- i ksenobiotika i u vodenih organizama. Nedavna istraživanja naše i drugih istraživačkih skupina pokazala su da procesiranje ksenobiotika u vodenih organizama uključuje regulaciju njihove apsorpcije putem SLC (solute carriers) uptake transportera organskih aniona i kationa, nakon čega slijedi njihova biotransformacija posredovana detoksikacijskim enzimima faze I. i II. Nastali metaboliti, a u nekim slučajevima i originalni spojevi, potom se aktivno izbacuju iz stanica posredstvom tzv. ABC (ATP binding cassette) transportera. Osim toga, pokazali smo i da je nedavno otkrivena grupa efflux transportera, tzv. MATE (multidrug and toxic compound extrusion) proteina, prisutna i aktivna u ribi zebrici (Danio rerio). Oslanjajući se naša nedavna istraživanja uptake i efflux transportera, u ovom projektu namjeravamo značajno unaprijediti naše razumijevanje (eko)toksikološke uloge odabranih SLC i MATE proteina koristeći se oruđima funkcionalne genomike zebrice. Ukratko, u projektu ćemo: (1) koristiti zebricu kao etabliran istraživački model kralješnjaka; (2) fokusirati se na uptake i efflux transportere nedavno karakterizirane in vitro (Oatp1d1, Oat1/3, Oct1, Mate7), s dodatkom transportera koji nisu bili analizirani u našim prijašnjim in vitro istraživanjima (Oatp2b1, Mates3 and 8); i (3) pokušat ćemo otkriti fiziološku i/ili obrambenu ulogu odabranih transportera korištenjem CRISPR/Cas9 pristupa editiranja genoma za stvaranje prvih genetički modificiranih zebrica za odabrane transportere, koje ćemo potom koristiti za određivanje posljedičnih promjena fenotipa, odnosno toksikološkog odgovora tijekom izlaganja modelnim supstratima i inhibitorima, uključujući okolišna zagađivala. ]]></summary_hr><summary_en><![CDATA[Polyspecific transmembrane proteins are integral components of a highly complex cellular defense in mammalian cells, and the two types of transporters are of particular toxicological relevance: the so-called uptake transporters and the efflux transporters. Analogous cellular defense systems are involved in processing of endo- and xenobiotics in aquatic organisms. It has been demonstrated by our research group and the others that processing of xenobiotics in aquatic organisms includes regulation of their absorption by the SLC (solute carriers) uptake transporters of organic anions and cations, followed by biotransformation of xenobiotic substances mediated by the phase I and II enzymes. The resulting metabolites, and is some cases even original xenobiotic substances, are then actively pumped out of the cells by the ABC transporters. In addition, we showed that a more recently recognized class of efflux transporters, MATEs (multidrug and toxic compound extrusion proteins) are present and active in zebrafish (Danio rerio). Therefore, based on extensive research our group done recently working both on the uptake and efflux transporters, in this project we aim to significantly improve our understanding of the (eco)toxicological role of selected SLC and MATE transporters using zebrafish  functional genomics tools. In short, we will (1) use zebrafish as a well-established research model; (2) focus on uptake and efflux transporters recently characterized in vitro (Oatp1d1, Oat1/3, Oct1, Mate7), with addition of transporters not evaluated in vitro in our previous research (Oatp2b1, Mates3 and 8); and (3), will try to decipher physiological and/or defensive role of selected transporters using CRISPR/Cas9 based genome editing tools for generation of the first transporter(s) deficient zebrafish, followed by determinations of resulting phenotype changes, and toxicological endpoints upon exposure to model substrates and inhibitors, including environmental contaminants.  ]]></summary_en></project><project>
<id>8533</id><title_hr><![CDATA[Promatranje, identifikacija i kvantifikacija mehanizama mehaničkog oštećenja na kompozitima ojačanim staklenim vlaknima primjenom različitih metoda nerazornog ispitivanja ]]></title_hr><title_en><![CDATA[Observation, identification and quantification of the mechanical damage mechanisms of glass fibre reinforced composites via multiple non-destructive testing methods]]></title_en><user_id>21447</user_id><user_firstLast_name>Zvonimir Tomičević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2019-04</proposal_call><code>UIP-2019-04-5460</code><acronim><![CDATA[FULLINSPECT]]></acronim><duration>01.02.2020 - 31.01.2025</duration><status>Završio</status><financ_value>265.403,15 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, Interdisciplinarne tehničke znanosti, </scie_field_hr><scie_field_en>Mechnical engineering, Interdisciplinary technological sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>26794, 27042, 855429, 856301, 867038, 868611, </team_members_id><team_members_names><![CDATA[Gabrijel Mađerić, Neggers Jan, Ana Vrgoč, Andrija Zaplatić, Borna Božović, Fran Šaban, ]]></team_members_names><keywords_hr><![CDATA[vlaknasti kompoziti,IR termografija,višeosni test,CT X-Zraka,in-situ test,digitalna korelacija slika/volumena,inverzna identifikacija,oštećenje,zamor]]></keywords_hr><keywords_en><![CDATA[Fibrous composites,IR thermography,multiaxial test,X-Ray CT,in-situ test,digital image/volume correlation,inverse identification,damage,fatigue]]></keywords_en><summary_hr><![CDATA[Kompozitni materijali su postali adekvatna zamjena za konvencionalne materijale u relevantnoj inženjerskoj primjeni. Posebno prikladna alternativa za klasične metalne materijale i legure su polimeri ojačani vlaknima. Međutim, neadekvatna karakterizacija i trenutno ograničena predvidljivost oštećenja vlaknastih kompozita rezultira primjenom visokih sigurnosnih standarda prilikom dimenzioniranja konstrukcija. Sukladno navedenom vrlo aktualne istraživačke teme su: a) karakterizacija materijala ojačanih vlaknima primjenom različitih nerazornih metoda, ovisno o promatranom mjerilu, b) razumijevanje mehanizama loma koji se pojavljuju u mikrostrukturi složene arhitekture, c) numeričko modeliranje kompozita ojačanih vlaknima na mikro razini, d) zamorna svojstva kompozitnih konstrukcija i određivanje inherentnih mehanizama loma. Stoga je cilj ovog projekta analizirati blisku povezanost između ortotropne elastičnosti i mehanizama oštećenja na makro i mikro razini, tijekom loma u unutrašnjosti kompozitnih materijala, kod višeosnih i zamornih režima opterećenja. Na dobivenim eksperimentalnim i numeričkim rezultatima promatrat će se mikromehanizmi oštećenja te njihova interakcija s lokaliziranim zonama polja deformacija, kako bi se mogla razumjeti njihova fizikalna pozadina. Da bi se postigao ovaj cilj, napredne istraživačke metode bit će potpuno povezane, naime koristit će se, infracrvena termografija i µ-tomografija za snimanje in-situ ispitanih uzoraka izrađenih od polimera ojačanih staklenim vlaknima (FRP), korelacija slike za mjerenje 2D i 3D polja pomaka (i deformacija) u unutrašnjosti materijala, i višerazinske numeričke simulacije upravljane eksperimentalnim podacima. Povezivanjem nove metode promatranja materijala (tomografije), napredne metode korelacije digitalnih volumena i preciznog 2D/3D modeliranja loma/odvajanja vlakana čini ovaj projekt posebno prikladnim za dobivanje pouzdanijeg uvida u mehanizme oštećenja FRPa na mikrorazini za različite režime opterećenja.]]></summary_hr><summary_en><![CDATA[Composites have emerged as an effective substitute for conventional engineering materials in major structural applications. Fibre reinforced polymers are especially regarded to be a suitable alternative for regular metallic materials and alloys. However, the characterisation and currently limited predictability of material failure resulted in high safety limits for the allowable construction design. For this reason, very contemporary research topics arise: a) characterisation of fibrous materials via multiple non-destructive testing methods depending on the length-scale, b) understanding of the failure mechanisms appearing in the complex microstructural architecture, c) numerical modelling of the fibre reinforced composites at the microscopic level, d) fatigue performance of composite structures and underlying failure mode assessment. Hence, the objective of the present proposal is to study the intimate interaction between orthotropic elasticity and damage mechanisms at the macro- and microscales during failure in the bulk of composite materials for different multiaxial, and fatigue loading histories. These experimental and numerical results will investigate the observed fracture micromechanisms and their interaction with strain localization in order to understand the underlying physical mechanisms. To achieve this goal, modern techniques will be seamlessly coupled, namely, infrared thermography and µ-tomography to image in-situ tested samples made of glass fibre reinforced polymer (FRP) composites, image correlation to measure displacement (and strain) fields in the bulk, and numerical simulations using the experimental information on multiple scales. The combination of a new promising observation technique (tomography), of advanced digital volume correlation, and of accurate 2D/3D modelling of fibre failure/debonding makes this project particularly suitable to get a better understanding of FRPs damage mechanisms at the microscale for various loading conditions.]]></summary_en></project><project>
<id>8547</id><title_hr><![CDATA[Strukturna kiralnost vs molekulska kiralnost]]></title_hr><title_en><![CDATA[Structural Chirality vs Molecular Chirality]]></title_en><user_id>564</user_id><user_firstLast_name>Andreja Lesac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-7978</code><acronim><![CDATA[SMChiral]]></acronim><duration>01.03.2020 - 31.07.2024</duration><status>Završio</status><financ_value>135.642,71 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, Fizika, Interdisciplinarne prirodne znanosti, </scie_field_hr><scie_field_en>Chemistry, Physics, Interdisciplinary natural sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>3241, 3232, 2736, 184, 864961, 856171, 24377, </team_members_id><team_members_names><![CDATA[Anamarija Knežević, Irena Dokli, Jurica Novak, Darko Kontrec, Aleksandra Šimanović, Antonija Ožegović, Katarina Zlatić, ]]></team_members_names><keywords_hr><![CDATA[kiralni dimeri, sinteza, mezogena svojstva, strukturna kiralnost, konformacijska analiza]]></keywords_hr><keywords_en><![CDATA[chiral dimers, synthesis, mesomorphic properties, structural chirality, conformational analysis]]></keywords_en><summary_hr><![CDATA[Znanstvenici različitih disciplina oduvijek su bili fascinirani kiralnošću. Jedan od najnovijih primjera spontane kiralnosti je &#39;&#39;twist-bend&#39;&#39; nematička faza (NTB). Formiranje degeneriranih zavojnica ne zahtijeva molekulsku kiralnost, već je za to dovoljno da molekula ima zakrivljeni oblik. Dok je odnos strukture i svojstava akiralnih materijala koji pokazuju NTB fazu intenzivno proučavan, istraživanja kiralnih materijala su rijetka. Kiralne strukture sa svojstvima tekućih kristala (LC) se uglavnom postižu spajanjem kolesterola kao mezogene jedinice što ograničava strukturnu raznolikost ili uvođenjem metilne skupine što nepovoljno djeluje na formiranje mezofaze.Predloženi projekt se bavi s dva problema: strukturom kiralnog materijala LC koja ne uključuje grananje i učinkom kiralnog ugljika na kiralnu samoorganizaciju.U okviru ovog projekta predlažemo razvoj i istraživanje nove klase kiralnih dimera sa semifleksibilnim kiralnim dijelom smještenim u razmaknicu ili u mezogenu jedinicu. Predloženi rad je kombinacija eksperimentalnih, računskih i spektroskopskih metoda u rasponu od organske sinteze, ispitivanje mezogenih svojstava standardnim tehnikama, snimanja AFM-a do računalnih metoda i spektroskopije cirkularnog dikroizma.Kao rezultat ovog projekta biti će dobiveni novi kiralni materijal čija se struktura može modificirati postepeno, što će pridonjeti boljem razumijevanju odnosa strukture i svojstava kiralnih zakrivljenih dimera te pružiti novi uvid u pojačanje molekularne kiralnosti u tekućim kristalima. Rezultati ove studije povećat će broj dostupnih materijala, kako za temeljna istraživanja, tako i za istraživanja usmjerene prema tehnološkim primjenama. Radom na projektu, mladi će istraživači imati priliku steći nova znanja koja nisu pokrivena njihovim diplomskim obrazovanjem i pridonijeti daljnjem razvoju kemije organskih matrijala u Hrvatskoj.]]></summary_hr><summary_en><![CDATA[Scientists of various disciplines have always been fascinated by chirality. One of the most recent examples of spontaneous chirality is the twist-bend nematic phase (NTB). Formation of degenerate helices does not require molecular chirality, instead, it is facilitated by the shape of bent molecules The structure-property relation of achiral materials exhibiting the NTB phase, has been intensively studied but investigation of chiral materials is scarce. The chiral liquid crystal (LC) structures were mainly achieved by connecting cholesterol mesogenic unit or incorporating a methyl group which limits the structural diversity which and destabilizes mesophase, respectively. The proposed project addresses two issues: the structure of chiral LC material which does not include branching and the effect of chiral carbon on chiral self-assembly. Within this project, we propose development and investigation of a novel class of chiral dimers with the semi-flexible chiral moiety positioned in the spacer or within the mesogenic unit. The proposed work combines experimental, computational and spectroscopic techniques ranging from organic synthesis, investigation of mesogenic properties by standard techniques, AFM imaging to computational methods and circular dichroism spectroscopy.The results of this project will provide novel chiral material which structure can be modified progressively, a better understanding of the structure-property relation of chiral bent-shaped dimers and provide new insight into amplification of molecular chirality in liquid crystals. The results of this study will expand the number of such materials available for both, the fundamental purposes, and for materials targeted towards technological applications. Working on the project, the young researchers will have the opportunity to gain new knowledge that is not covered by their graduate education and contribute to the further development of organic material chemistry in Croatia.]]></summary_en></project><project>
<id>8560</id><title_hr><![CDATA[Alfa satelitska DNA u evoluciji mreža genske modulacije]]></title_hr><title_en><![CDATA[Alpha satellite DNA in evolution of gene modulatory networks]]></title_en><user_id>183</user_id><user_firstLast_name>Đurđica Ugarković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-6915</code><acronim><![CDATA[AlphaSatGenNet]]></acronim><duration>01.02.2020 - 30.06.2024</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>3003, 559, 25758, 21311, 861750, 863819, </team_members_id><team_members_names><![CDATA[Branka Bruvo Mađarić, Isidoro Feliciello, Dušan Kordiš, Antonio Sermek, Sven Ljubić, Alfredo Procino, ]]></team_members_names><keywords_hr><![CDATA[satelitska DNA, transkripcija, genska ekspresija, evolucija, toplinski stres, epigenetika]]></keywords_hr><keywords_en><![CDATA[satellite DNA, transcription, gene expression, evolution, heat stress, epigenetics]]></keywords_en><summary_hr><![CDATA[Satelitske DNA su uzastopno ponovljene sekvence koje se preferencijalno grupiraju unutar konstitutivnog heterokromatina. Međutim, u nekim slučajevima, one su djelomično raspršene u blizini gena unutar eukromatina. Smatra se da su takva mješovita organizacija i uzajamno djelovanje između satelitskih ponavljanja unutar heterokromatina i eukromatina odgovorni za učinak satelitske DNA na modulaciju ekspresije gena koja je prvi put pokazana u kukcu Tribolium castaneum.Primarni cilj predloženog projekta je istražiti ulogu ljudske alfa satelitske DNA u modulaciji genske ekspresije. Alfa satelitska DNA je glavna ljudska satelitska DNA smještena u (peri)centromernim područjima svih ljudskih kromosoma, a  zajednička je svim primatima. Pored (peri)centromernog položaja, bioinformatička pretraga ljudskog genoma otkriva alfa satelitska ponavljanja raspršena unutar eukromatina, uz gene, i ukazuje na sličnu genomsku organizaciju glavnog satelita kukca Tribolium castaneum i alfa satelitske DNA. Na temelju ovog zapažanja može se pretpostaviti da alfa satelitski transkripti mogu potaknuti epigenetski mehanizam koji modificira kromatin na raspršenim alfa satelitskim ponavljanjima, što dovodi do promjena u ekspresiji obližnjih gena.Koristeći eksperimentalni pristup, planiramo istražiti utjecaj glavne ljudske alfa satelitske DNA na ekspresiju susjednih gena, kao i molekularni mehanizam njenog modulatornog djelovanja  na gene. Osim toga, izvršit će se bioinformatička analiza i usporedba alfa satelitskih ponavljanja raspršenih unutar eukromatina svih sekvenciranih genoma primata kao i karakterizacija njima susjednih gena. Na temelju dobivenih podataka očekujemo da ćemo otkriti moguću ulogu alfa satelitske DNA u fiziologiji i evoluciji mreža genske modulacije u primata.]]></summary_hr><summary_en><![CDATA[Satellite DNAs are tandemly repeated sequences preferentially clustered within constitutive heterochromatin. However, in some cases, they are found partially dispersed in the vicinity of genes within euchromatin. Such mixed organization and interplay between repeats located within heterochromatin and euchromatin is proposed to be responsible for the gene-modulatory effect of satellite DNA which was first shown in the beetle Tribolium castaneum. The primary aim of the proposed project is to investigate the gene-modulatory role of human alpha satellite DNA. Alpha satellite DNA is a major human satellite located in the (peri)centromeric regions of all human chromosome and is common for all primates. In addition to (peri)centromeric location, a bioinformatics search of the human genome reveals alpha satellite repeats dispersed within euchromatin, adjacent to genes, and points to a similar genomic organization of a major Tribolium castaneum satellite and alpha satellite DNA. Based on this observation it could be proposed that alpha satellite transcripts could induce an epigenetic mechanism that modifies chromatin at dispersed alpha satellite repeats, leading consequently to changes in the expression of nearby genes.Using experimental approach, we plan to study influence of a major human alpha satellite DNA on the expression of adjacent genes as well as a molecular mechanism of its gene modulatory activity. In addition, bioinformatics analysis and comparison of alpha satellite repeats dispersed within euchromatin of all sequenced primate genomes and characterization of their associated genes will be performed. Based on obtained data we expect to reveal the possible role of alpha satellite DNA in physiology and in the evolution of gene modulatory networks in primates.]]></summary_en></project><project>
<id>8580</id><title_hr><![CDATA[Ekologija aerobnih anoksigenih fototrofa u Jadranskom moru]]></title_hr><title_en><![CDATA[Ecology of Aerobic Anoxygenic Phototrophs in the Adriatic Sea]]></title_en><user_id>437</user_id><user_firstLast_name>Danijela Šantić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2019-04</proposal_call><code>UIP-2019-04-8401</code><acronim><![CDATA[ADRISAAF/ADRISAAF]]></acronim><duration>01.02.2020 - 31.01.2025</duration><status>Završio</status><financ_value>264.143,21 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, Interdisciplinarne prirodne znanosti, </scie_field_hr><scie_field_en>Biology, Interdisciplinary natural sciences, </scie_field_en><institution_hr><![CDATA[Institut za oceanografiju i ribarstvo]]></institution_hr><institution_en><![CDATA[Institute of Oceanography and Fisheries]]></institution_en><team_members_id>19982, 3610, 531, </team_members_id><team_members_names><![CDATA[Željana Fredototvić, Željka Trumbić, Ana Vrdoljak Tomaš, ]]></team_members_names><keywords_hr><![CDATA[Aerobni anoksigeni fototrofi, pufM, gen, mikrobna hranidbena mreža, protok ugljika, sezonalnost, trofički gradijent, Jadransko more]]></keywords_hr><keywords_en><![CDATA[Aerobic Anoxygenic Phototrophs, pufM gen, microbial food web, carbon flux,  seasonality, trophic gradient, Adriatic Sea]]></keywords_en><summary_hr><![CDATA[Aerobni anoksigeni fototrofi široko su rasprostranjene u okolišu te čine i do 25 % ukupne bakterijske populacije u moru. Odlikuje ih visoka stopa rasta te značajno veća duljina stanica u odnosu na ostale bakterije. Pod pritiskom su ispaše od strane predatora te se na taj način njihova biomasa prenosi na više trofičke razine. Navedeno upućuje na njihovu važnost u morskoj hranidbenoj mreži te u biogeokemijskim ciklusima. Svoje predstavnike imaju među Alpha-, Beta- i Gammaproteobacteria-ma. Temeljem analize pufM gena ova funkcionalna grupa podijeljena je u 12 različitih filogrupa te zahvaljujući spomenutoj genetskoj raznolikosti stvara svoj odgovor prema ekološkim čimbenicima. U dosadašnjim istraživanjima u Jadranskom moru utvrđena je njihova prisutnost, no nema detaljnog istraživanja raspodjele njihove brojnosti, sastava zajednice, stopa rasta i ekološkim čimbenika koji utječu izravno na njih bilo na vremenskoj ili prostornoj skali. Zahvaljujući metodologiji korištenoj u ovom projektnom prijedlogu omogućit će se bolji uvid u ciklus ugljika u moru. Predloženi projektni prijedlog obuhvaća dosad ne korištenu metodologiju na području istraživanju mikrobne zajednice u Hrvatskoj. Uspostavom nove istraživačke grupe značajno će se proširiti istraživanje mikrobne zajednice i njezine važnosti u Jadranskom, a samim time i Sredozemnom moru.]]></summary_hr><summary_en><![CDATA[Clarify the theoretical background of the project and explain the research problems and in what way the research contributes to the development of the area of research, society and economy.Aerobic anoxygenic phototrophs are widespread in the environment and account for up to 25% of the total bacterial population in the sea. They are characterized by a high growth rate and significantly higher cell length compared to other bacteria. They are under the pressure of the predators and therefore their biomass is transferred to more trophic levels. This indicates their importance in the marine food web and in biogeochemical cycles. Furthermore, AAP has its representatives among Alpha-, Beta- and Gammaproteobacteria. Based on the pufM gene analysis, the appropriate marker for AAP light harvesting centers, this functional group is divided into 12 different phylogroups. Recent research suggests that this bacterial functional group, thanks to genetic diversity, creates its response to ecological factors.Their presence in the Adriatic Sea has been studied so far, but there is no detailed study of their abundance, community composition, growth rate and ecological factors affecting them directly on either time scale or spatial scale.Thanks to the methodology used in this project proposal, a better insight into the carbon cycle in the sea will be provided. The proposed project proposal includes unused methodology in the area of microbial research in Croatia. The establishment of a new research group will significantly expand the research of the microbial community and its importance in the Adriatic, and thus the Mediterranean Sea.]]></summary_en></project><project>
<id>8581</id><title_hr><![CDATA[Topografija vlasti: istočnojadranski gradovi u srednjovjekovnim prostorima vlasti ]]></title_hr><title_en><![CDATA[Topographies of Power: Eastern Adriatic Cities in Medieval Spheres of Power]]></title_en><user_id>421</user_id><user_firstLast_name>Irena  Benyovsky Latin</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-2055</code><acronim><![CDATA[TOPOS]]></acronim><duration>15.01.2020 - 14.01.2025</duration><status>Završio</status><financ_value>76.979,23 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Povijest, Interdisciplinarne humanističke znanosti, </scie_field_hr><scie_field_en>History, Interdisciplinary humanities, </scie_field_en><institution_hr><![CDATA[Hrvatski institut za povijest]]></institution_hr><institution_en><![CDATA[Croatian Institute of History]]></institution_en><team_members_id>3987, 535, 2688, 460, 509, 476, 466, 1036, 633, 330, 383, 436, 534, 6365, 867090, </team_members_id><team_members_names><![CDATA[Ratko Vučetić, Tonija Andrić, Ivan Majnarić, Sandra Begonja, Zrinka Nikolić Jakus, Bruno Škreblin, Marija Mogorović Crljenko, Danijela Doblanović Šuran, Marija Karbić, Zrinka Pešorda Vardić, Gordan Ravančić, Ante Birin, Dušan  Mlacović, Ivana Haničar Buljan, Ante Bećir, ]]></team_members_names><keywords_hr><![CDATA[Istočni Jadran, gradovi, hrvatsko srednjovjekovlje, topografija vlasti, društveno umrežavanje]]></keywords_hr><keywords_en><![CDATA[Eastern Adriatic, cities, Croatian Middle Ages, topography of power, social networking]]></keywords_en><summary_hr><![CDATA[Projekt TOPOS će istražiti i predstaviti istočnojadranske gradove u prostorima vlasti tijekom razvijenog i kasnog srednjeg vijeka. Istražit će se odnos gradova i vlasti kako na pojedinačnim primjerima i razdobljima, tako i komparativno – uspoređujući gradove koji su bili u sferama različitih vlasti i gradove unutar istog prostora vlasti (u kontekstu šireg sredozemnog ili kontinentalnog područja). Pod pojmom topografija vlasti podrazumijeva se određivanje prostora vlasti nad gradovima, definiranje njezina opsega i (dis)kontinuiteta. Fokus će biti i na kanalima i instrumentima provođenja vlasti, kao i na upravnim i administrativnim osobama. Suradnici će se usredotočiti na mobilnosti ljudi i znanja na istočnom Jadranu (ali i šire) – na međusobnim institucionalnim, društvenim i prostornim utjecajima te utjecajima iz središnje ili regionalne vlasti. Izradit će se relacijska on-line baza podataka u koju će biti uneseni podaci o promjenama vlasti, o različitim razinama vlasti (središnjoj, regionalnoj, lokalnoj), o predstavnicima vlasti (upravnim i administrativnim osobama), s podacima o ključnim promjenama u prostoru, upravi i društvu vezanima uz određenu vlast, te s pokazateljima stupnja autonomije. Ključne promjene u prostoru vezane uz promjenu vlasti bit će predstavljene i na on-line digitalnim mapama odabranih gradova. Na temelju prikupljenih podataka, suradnici će na (re)interpretirati složen položaj i funkcioniranje istočnojadranskih gradova u odnosu na sfere vlasti. Istraživanja će se temeljiti na arhivskoj građi te relevantnoj literaturi. Ovim projektom želi se naglasiti složena stvarnost gradova istočnog Jadrana u prostorima vlasti u srednjem vijeku, namjerava se jasnije istaknuti njihova specifičnost te nadlokalna perspektiva i postojanje društvenih mreža.]]></summary_hr><summary_en><![CDATA[The project TOPOS will explore and present Eastern Adriatic cities in the spheres of power during the High and Late Middle Ages. It will explore the relations between these urban communities and the governing powers on individual examples, but also comparatively - by comparing cities within the spheres of different (central and / or regional) authorities as well as cities within the same sphere of authority / power in broader Mediterranean / Central European context. The term “topography of power” refers to designating the area of authority (central, regional, municipal) over the cities, defining its character, reach, and continuity, and identifying the ways and channels used to consolidate and enforce that power. Team members will also focus on the mobility of people and transfer of knowledge in the Eastern Adriatic and beyond by researching mutual institutional, social and spatial influences and impacts from central and regional authorities. A relational on-line database will be created that will contain data on governing powers, as well as on different levels of governance (local, regional, central), on representatives of power and office-holders, on key changes in urban space, governance and society related to a particular authority, and on indicators of the degree of existing urban autonomy. Key changes in public space related to the changes of power will also be presented via online digital maps of selected cities. Based on the collected data, the team members will, in a comparative and interdisciplinary way, interpret the complex position of Eastern Adriatic cities in relation to different levels of power. The research will be based on archival field work, as well as on a relevant literature. This project aims to emphasize the complex reality of Eastern Adriatic cities in the Middle Ages, intending to make their supralocal perspective and supralocal networks, as well as their specifics, more visible.]]></summary_en></project><project>
<id>8582</id><title_hr><![CDATA[Razdvajanje uticaja parametara u inžinjerskom modeliranju s parametarskom identifikacijom]]></title_hr><title_en><![CDATA[Separation of Parameter Influence in Engineering Modelling and Parameter Identification]]></title_en><user_id>4072</user_id><user_firstLast_name>Ivica Kožar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-7926</code><acronim><![CDATA[SEPAEMPI]]></acronim><duration>02.12.2019 - 01.12.2023</duration><status>Završio</status><financ_value>121.308,65 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Građevinarstvo, Temeljne tehničke znanosti, Interdisciplinarne tehničke znanosti, </scie_field_hr><scie_field_en>Civil engineering, Basic engineering sciences, Interdisciplinary technological sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Građevinski fakultet u Rijeci]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Civil Engineering]]></institution_en><team_members_id>4880, 5624, 6013, 6135, 13541, 6912, 6843, 26852, 861729, 865452, </team_members_id><team_members_names><![CDATA[Joško Ožbolt, Boris Podobnik, Neira Torić Malić, Silvija Mrakovčić, Ivana Štimac Grandić, Natalija Bede, Anamarija Perušić Pribanić, Ivana Pranjić, Tea Sulovsky, Ivan Zambon, ]]></team_members_names><keywords_hr><![CDATA[beton, puzanje, konstrukcija, sistemski model, inverzni model, separacija parametara]]></keywords_hr><keywords_en><![CDATA[concrete, creep, structure, system model, inverse model, parameter separation]]></keywords_en><summary_hr><![CDATA[Što se tiče puzanja betona, cilj ovog istraživanja je eksperimentalno i numerički istražiti interakciju različitih procesa vezanih uz vremenski ovisnu deformaciju betona. Trenutno ne postoji eksperimentalna i numerička studija u kojoj se istražuju aspekti interakcije vremenske deformacije betona radi boljeg razumijevanja puzanja betona.Potrebno je formulirati poseban postupak za izdvajanje relevantnih parametara iz neizravnih mjerenja, tzv. “inverzna procedura”. Glavna poteškoća s inverznom procedurom je u tome što je općenito nestabilna, tj., osjetljiva na pogreške u mjerenjima.Novost predloženog projekta je razvoj postupka koji bi mogao odvojiti utjecaj pojedinih parametara u modelu. Postoje metode koje se već koriste u tu svrhu, ali nisu prikladne za građevinske materijale jer se temelje na velikim skupovima podataka. Ovdje nemamo veliki broj rezultata ispitivanja; problem ćemo prevladati proizvodnjom vlastitih eksperimenata i postupaka koji se temelje na kombinaciji determinističkog i stohastičkog opisa materijala.]]></summary_hr><summary_en><![CDATA[Regarding the creep of concrete, the aim of the present research project is to experimentally and numerically investigate the interaction between different processes related to the time-dependent deformation of concrete.  Currently there is no experimental and numerical study in which interaction aspects of time deformation of concrete is investigated in order to better understand creep of concrete.Special procedure has to be formulated for extraction of relevant parameters from indirect measurements, the so called “inverse procedure”. The main difficulty with inverse procedure is that it is generally unstable, i.e., sensitive to errors in measurements.Novelty of the proposed project is development of a procedure that could separate the influence of certain parameters in the model. There are methods that are already used for that purpose but are not suitable for civil engineering materials because they are based on large data sets. Here, we do not have a vast number of test results; we are going to overcome the problem by producing own experiments and procedures based on a combination of deterministic and stochastic material description.]]></summary_en></project><project>
<id>8584</id><title_hr><![CDATA[Strategije patogenosti fitoplazmi: efektori, faktori virulencije i pokretni genetički elementi]]></title_hr><title_en><![CDATA[Strategies of phytoplasma pathogenicity: effectors, virulence factors and mobile genetic elements ]]></title_en><user_id>12617</user_id><user_firstLast_name>Martina Šeruga Musić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-2469</code><acronim><![CDATA[PathoPhyto]]></acronim><duration>01.02.2020 - 31.08.2024</duration><status>Završio</status><financ_value>143.075,19 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>12676, 26493, 13554, 26515, 861503, </team_members_id><team_members_names><![CDATA[Foissac Xavier, Marina Drčelić, Saskia Hogenhout, Chih-Horng Kuo, Bruno Polak, ]]></team_members_names><keywords_hr><![CDATA[bakterije, efektor, filogenomika, fitoplazma, patogenost, proteomika, virulencija]]></keywords_hr><keywords_en><![CDATA[bacteria, effector, pathogenicity, phylogenomics, phytoplasma, proteomics, virulence]]></keywords_en><summary_hr><![CDATA[Bakterije roda &#39;Candidatus Phytoplasma&#39; su pleomorfni unutarstanični patogeni, uzročnici brojnih bolesti biljaka. Prenose se putem kukaca-vektora, a njihovi složeni životni ciklusi uključuju parazitiranje u oba domaćina. Uzgoj fitoplazmi u akseničnoj kulturi još uvijek je neuspješan. Metagenomički pristup i napredak tehnologija sekvenciranja omogućili su sastavljanje nekolicine genoma fitoplazmi, od kojih je jedan rezultat uspješno završenog Uspostavnog istraživačkog projekta. Mali genomi ovih patogena (530-1350 bp) reducirani su u mnogim metaboličkim putevima, a bogati ponavljajućim sljedovima i pokretnim genetičkim elementima. Era genomike donijela je nove mogućnosti pronalaska potencijalnih faktora virulencije, efektora i ostalih mehanizama patogenosti. U prethodnom HRZZ projektu, sekvenciranjem i analizama genoma fitoplazme &#39;Ca. P. solani&#39;, bioinformatičkim alatima identificirano je 38 potencijalnih efektora. U sklopu ovog projekta provele bi se funkcionalne studije odabranih efektora te istražila njihova raznolikost. Nadalje, istražila bi se raznolikost potencijalnih mobilnih jedinica (PMUs) unutar kojih su često smješteni gene za efektore. Kod patogenih bakterija, površinski i membranski proteini smatraju se važnim faktorima virulencije. Stoga bi se provela istraživanja interakcije membranskog proteina Stamp fitoplazme &#39;Ca. P. solani&#39; s proteinima kukaca, s naglaskom na specifičnost ovisno o genotipu fitoplazme i vrsti kukca-vektora. Fitoplazma &#39;Ca. P. solani&#39; širokog je kruga domaćina, uključujući gospodarski značajne kulture (vinova loza, kukuruz, krumpir, rajčica, paprika), a prenosi ju više vrsta kukaca. Jedna je od najraširenijih fitoplazmi u Hrvatskoj. Podaci o specifičnim efektorima i interakcijama s biljnim domaćinima i kukcima ukazali bi na faktore koji određuju njenu prilagodljivost različitim domaćinima i ekološkim sustavima te zajedno s podacima o molekularnoj epidemiologiji dali nove mogućnosti u pronalasku rješenja kontrole širenja ovog patogena.]]></summary_hr><summary_en><![CDATA[Bacteria of the genus &#39;Candidatus Phytoplasma&#39; are pleomorphic intracellular pathogens causing numerous plant diseases worldwide. They are transmitted by phloem-feeding insects, and their complex life-cycles include parasitism in both hosts. Axenic cultivation of phytoplasmas is still challenging. Metagenomic approach and new sequencing technologies enabled the assembly of several phytoplasma genomes, including the one done in the scope of the previous Installation Research Project. Phytoplasma genomes are small (530-1350 bp) and reduced in many metabolic pathways, but repeat-rich, encompassing characteristic mobile genetic elements. Genomics era has brought new possibilities in finding potential virulence factors, effectors and other pathogenicity mechanisms. In the previous CSF project, sequencing and analysis of &#39;Ca. P. solani&#39; phytoplasma genome identified 38 potential effectors by using bioinformatics tools. As a part of this project, functional studies of selected effectors and studies on their diversity would be performed. Diversity of potential mobile units (PMUs), often encompassing effector genes, would also be studied. In pathogenic bacteria, surface and membrane proteins are considered as important virulence factors. Therefore, studies on the interaction of the &#39;Ca. P. solani&#39; membrane protein Stamp with insect proteins, together with specificity depending on the phytoplasma genotype and the insect vector type, would be performed. Phytoplasma &#39;Ca. P. solani&#39; has a wide hosts range, including economically significant crops (grapevines, corn, potatoes, tomatoes, peppers), and is transmitted by several insect species. It is one of the most common phytoplasmas in Croatia. Data on specific effectors and their interactions with plants and insects would indicate factors determining its adaptability to different hosts and ecosystems and together with the data on molecular epidemiology, offer new opportunities in disease management and risk assessment.]]></summary_en></project><project>
<id>8599</id><title_hr><![CDATA[Zapadnoistarska antiklinala kao idealni prirodni laboratorij za proučavanje regionalnih diskordancija u karbonatnim stijenama]]></title_hr><title_en><![CDATA[Western Istrian Anticline as an ideal natural laboratory for the study of the regional unconformities in carbonate rocks]]></title_en><user_id>2669</user_id><user_firstLast_name>Goran Durn</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-8054</code><acronim><![CDATA[WIANLab]]></acronim><duration>01.04.2020 - 30.09.2024</duration><status>Završio</status><financ_value>161.664,34 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Geologija, </scie_field_hr><scie_field_en>Geology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Rudarsko-geološko-naftni fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mining, Geology and Petroleum Engineering]]></institution_en><team_members_id>12953, 6786, 2920, 3252, 3030, 13340, 3920, 22781, 13250, 26053, 6464, 4970, 856264, 864993, </team_members_id><team_members_names><![CDATA[Igor Vlahović, Ivan Sondi, Marta Mileusnić, Uroš Barudžija, Stanko Ružičić, Blanka Cvetko Tešović, Maja Martinuš, Vedran Rubinić, Branimir Šegvić, Nadia Sabatino, Srečo Davor Škapin, Ivan Razum, Ivor Perković, Darko Matešić, ]]></team_members_names><keywords_hr><![CDATA[Karbonatna sukcesija, regionalna diskordancija, paleotlo, klasifikacija, dijageneza, paleookoliš, paleoklima, Istra]]></keywords_hr><keywords_en><![CDATA[Carbonate succession, regional unconformity, palaeosol, classification, diagenesis, palaeoenvironment, palaeoclimate, Istria]]></keywords_en><summary_hr><![CDATA[Istraživanje paleotala (Pt) vezanih uz karbonatne sukcesije izuzetno je propulzivna tema u geoznanostima s aktualnim istraživanjima koja imaju za cilj pronalaženje novih i razvijanje postojećih primjena Pt, kao što su npr. rekonstrukcija paleookoliša i paleoklime, transformacija i alteracija pedogenetskih minerala tijekom procesa zalijeganja,  te uspostavljanje geokronologije terestričkih sedimenata. Cilj projekta je istražiti Pt povezana s četiri regionalne diskordancije (RD) u plitkovodnim marinskim karbonatnim sukcesijama Zapadnoistarske antiklinale kao indikatore paleookoliša, paleoklime i provenijencije. Istraživanja će obuhvatiti Pt i s njima asocirane sedimente, koji uključuju paleookršenu podinu te krovinu paleotala. Tako zajednički istraženi slijed sedimenata i Pt može pružiti cjelovitu informaciju o nastanku Pt. Istraživanje  će biti organizirano s fokusom na (a) Pt povezana s RD donji kimeridž–gornji titon, (b) Pt povezana s RD gornji apt–gornji alb, (c) Pt povezana s RD gornji cenoman/gornji santon–donji eocen, (d) Pt povezana s RD gornji eocen do danas i (e) silicijske dijagenetske sedimente  (SDS) u gornjoalbskim karbonatima. Svaka RD i SDS biti će zastupljeni s tri do četiri lokaliteta. Istraživanju Pt pristupiti ćemo visokorezolucijski, što uključuje detaljne analize petnaest atributa po dubini profila.  Nakon obavljenih analiza, Pt će biti klasificirana i njihovo formiranje interpretirano. Kombinacija povoljnih taložnih okoliša koji su rezultirali dobro definiranim stratigrafskim hijatusima duljeg trajanja i vrlo blage naknadne tektonike u Zapadnoistarskoj antiklinali omogućili su formiranje idealnog prirodnog laboratorija za multidisciplinarno istraživanje RD u karbonatnim stijenama. Smatramo da će rezultati WIANLab-a biti važan doprinos istraživanoj temi, te da imaju dobar potencijal za buduća, uglavnom primijenjena istraživanja (npr. REE u boksitima, koncept terroira).]]></summary_hr><summary_en><![CDATA[Investigation of palaeosols (Ps) related to carbonate successions is a global endeavour in geosciences, with active work that presents a variety of new and developing applications such as the utility of Ps for reconstructing palaeoenvironments and paleoclimates, the transformation and alteration of pedogenic minerals, and the establishment of geochronology within terrestrial sedimentary strata. The project goal is to investigate Ps related to the four regional unconformities in the shallow marine carbonate successions within the Western Istrian Anticline (WIA) as indicators of palaeoenvironments, palaeoclimates and provenance. Ps and deposits around them (palaeokarstified bedrock and immediate cover) as a unique package that only as a whole gives complete information on the Ps genesis will be studied. The work will be organized with the focus on (a) Ps related to the Lowermost Kimmeridgian–Upper Tithonian regional unconformity (RU), (b) Ps related to the  Upper Aptian–Upper Albian RU, (c) Ps related to the Upper Cenomanian/Upper Santonian–Lower Eocene RU, (d) Ps related to the Upper Eocene–Recent RU and (e) quartz-rich diagenetic sediments (QRDS) within the Upper Albian carbonate rocks. Each RU and  QRDS will be represented with three to four locations. High-resolution depth approach to investigation of Ps including detailed analysis of 15 attributes will be applied. After all attributes are accomplished, Ps will be classified and their formation interpreted. Combination of favourable depositional environments resulting in well-defined stratigraphic hiatuses of long duration and very gentle post-depositional tectonics in the WIA enabled formation of the ideal natural laboratory (NLab) for multidisciplinary study of RU in carbonate rocks. We find that WIANLab&#39;s results will be an important contribution to the research topic and that they have a good potential for future, mainly for the applied investigations (e.g. REE in bauxites, concept of terroir).]]></summary_en></project><project>
<id>8604</id><title_hr><![CDATA[Reguliranje funkcije štitne i doštitne žlijezde i homeostaze kalcija u krvi]]></title_hr><title_en><![CDATA[Regulation of thyroid and parathyroid function and blood calcium homeostasis]]></title_en><user_id>118</user_id><user_firstLast_name>Tatijana Zemunik</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-2593</code><acronim><![CDATA[THPTHCAREGULATION]]></acronim><duration>01.03.2020 - 29.02.2024</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Split School of Medicine]]></institution_en><team_members_id>137, 63, 3571, 588, 611, 25811, 19036, 22517, 4137, 8532, 858431, 858324, 17479, 26007, </team_members_id><team_members_names><![CDATA[Maja Barbalic, Vesna Boraska Perica, Ante Punda, Dubravka Brdar, Vesela Torlak, Valdi Pešutić-Pisac, Ivana Gunjača, Dean Kaličanin, Caroline Hayward, Mirjana Babić Leko, Mladen Lešin, Nikolina Pleić, Antonela Matana, Marko Vuletić, ]]></team_members_names><keywords_hr><![CDATA[hormoni i antitijela štitne žlijezde, parametri homeostaze kalcija u krvi, genetska varijanca, predikcijska analiza, analiza ekspresije gena]]></keywords_hr><keywords_en><![CDATA[thyroid hormones and antibodies, parameters of calcium homeostasis, genetic variance, prediction analysis, gene expression analysis]]></keywords_en><summary_hr><![CDATA[Publicirani rezultati naše istraživačke skupine predstavljaju prve identificirane genetske varijante za većinu hormona/antitijela štitne žlijezde. Udio objašnjene genetske varijance za hormon doštitne žlijezde (PTH) iznosi samo 5,34% dok za kalcitonin i osteokalcin koji zajedno s PTH reguliraju homeostazu kalcija u krvi nema provedenih cjelogenomskih studija do sada. Predikcijske analize poprimaju sve veći značaj u posljednjih nekoliko godina. Cilj takvih analiza je predviđanje vrijednosti kvantitativnog svojstva baziranog na zajedničkom učinku genetskih i okolišnih čimbenika. Ovakav tip analiza nije primijenjen za predviđanje razine hormona/antitijela štitne žlijezde, kao ni za parametre koju reguliraju homeostazu kalcija u krvi. Stoga su prva dva cilja predloženog projekta povećanje udjela objašnjene genetske varijance za hormone/antitijela štitne žlijezde i parametara regulacije homeostaze kalcija u krvi i predikcija istih bazirana na genetskim i okolišnim čimbenicima. Istraživanje će biti provedeno na 2.000 ispitanika (populacije imenovane Korčula2, Korčula3), a rezultati će biti objedinjeni meta-analizom s prethodno dobivenim rezultatima na 3.000 ispitanika (populacije imenovane Split, Korčula1, Vis) za hormone i antitijela štitne i doštitne žlijezde, dok će analize za vrijednosti kalcitonina i osteokalcina biti provedene po prvi put na ukupno 5.000 ispitanika (u svim populacijama). Svi ispitanici regrutirani su iz projekta „10.001 Dalmatinac“ te raspolažemo genotipskim i nizom anamnestičkih i fenotipski mjerljivih podataka potrebnih za ove analize. Treći cilj projekta predstavlja funkcionalnu potvrdu identificiranih gena koji se povezuju s razinom tireoglobulina (Tg) i pozitivnim nalazom protutijela štitne žlijezde (TPOAt i/ili TgAt) u plazmi. Utvrdit će se razlika u ekspresiji dva gena u patološkom u odnosu na zdravo tkivo štitne žlijezde imunohistokemijskim metodama. Ovakva istraživanja preduvjet su razvoja personalizirane medicine.]]></summary_hr><summary_en><![CDATA[First identified genetic variants for most thyroid hormones/antibodies have been recently published by our research group. For now, only 5.34% of genetic variance has been explained for parathyroid hormone (PTH) levels while calcitonin and osteocalcin, which together with PTH regulate blood calcium homeostasis, have not been analysed on a genome-wide level. Prediction analyses have gained increasing significance over the last few years. The aim of such analyses is to predict the value of a quantitative trait based on genetic and environmental parameters. These analyses have not been performed in the prediction of thyroid hormones/antibodies levels or blood calcium homeostasis parameters. Therefore, the first two goals of the proposed project are increasing the amount of explained genetic variance of thyroid complex phenotypes and parameters of calcium homeostasis, and their prediction based on identified genetic variants and environmental factors. The analysis of thyroid hormones/antibodies will be performed in 2.000 participants (populations named Korčula2, Korcula3), and the results will be meta-analyzed with previously obtained results of 3.000 participants (populations named Split, Korcula1, Vis). Analyses of calcitonin and osteocalcin will be performed in a total of 5.000 participants (in all populations), for the first time. All participants are recruited through the project „10.001 Dalmatians“ and have genotypic and a series of anamnestic and phenotypic data needed for these analyses. The third project goal is based on the best results of our previous project and represents the functional studies of genes identified to be associated with thyroglobulin (Tg) plasma levels and positive antibody (TPOAb and/or TgAb) findings. It is planned to establish the difference in the gene expression between pathological and healthy thyroid tissue using immunohistochemical methods. Such studies are a prerequisite for the development of personalized medicine.]]></summary_en></project><project>
<id>8609</id><title_hr><![CDATA[Otpornost potrošača na narušavanje privatnosti u online okruženju]]></title_hr><title_en><![CDATA[Consumer resilience to online privacy violation]]></title_en><user_id>177</user_id><user_firstLast_name>Jelena Budak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-7886</code><acronim><![CDATA[REPRICON]]></acronim><duration>03.01.2020 - 02.01.2024</duration><status>Završio</status><financ_value>49.771,05 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, </scie_field_hr><scie_field_en>Economy, </scie_field_en><institution_hr><![CDATA[Ekonomski institut Zagreb]]></institution_hr><institution_en><![CDATA[Institute of Economics in Zagreb]]></institution_en><team_members_id>25916, 5908, 27354, 19782, 174, </team_members_id><team_members_names><![CDATA[Šime Lugović, Zvjezdan Penezić, Bruno Škrinjarić, Sunčana Slijepčević, Edo Rajh, ]]></team_members_names><keywords_hr><![CDATA[otpornost, narušavanje privatnosti online, privatnost u online okruženju, ponašanje potrošača online, prilagodba ponašanja]]></keywords_hr><keywords_en><![CDATA[resilience, online privacy violation, privacy online, consumer behavior online, adaptive responses]]></keywords_en><summary_hr><![CDATA[Cilj projekta je razviti i empirijski testirati konceptualni model otpornosti korisnika Interneta koji su iskusili povredu privatnosti online. Sveobuhvatni popis odrednica otpornosti potrošača i prilagodbi ponašanja u online okruženju temeljit će se na interdisciplinarnom pristupu u proučavanju postojeće literature o otpornosti i ponašanju potrošača u online okruženju, u cilju definiranja varijabli u modelu. Objedinjavanje različitih koncepata otpornosti i integriranje suvremenih teorija ponašanja potrošača koristit će se za razvoj teorijskog okvira za online otpornost potrošača. U projektu će se razviti i  ocijeniti valjanost jedinstvenog mjernog instrumenta za uspješno ispitivanje čitavog modela na anketnim podacima prikupljenima na neto uzorku od 1000 korisnika interneta koji su doživjeli narušavanje privatnosti online. Odnosi među varijablama u modelu će se analizirati modeliranjem strukturalnim jednadžbama. Istražit će se i tehnička sigurnost na internetu i percipirani rizik povrede privatnosti u kontekstu ponašanja potrošača, tipologija korisnika interneta koji su doživjeli narušavanje privatnosti online, kao i povezanost otpornosti potrošača na povredu privatnosti online s digitalizacijom javnog sektora. Integrirani rezultati istraživanja doprinijet će definiranju završnog modela otpornosti potrošača online. Istraživanje u okviru REPRICON-a će ujediniti segmentirane i kontradiktorne nalaze prethodnih studija, identificirati najnovije trendove u istraživanju u različitim disciplinama, i iznaći teorijski i empirijski okvir za daljnja primijenjena istraživanja u društvenim znanostima. Implikacije i preporuke za politike koje proizlaze iz istraživanja koristile bi poslovnoj zajednici za razvoj učinkovitih poslovnih strategija. Očekivani je učinak i u podizanju svijesti donositelja javnih politika o važnosti zaštite privatnosti u online okruženju, kao i u odgovoru na pitanje kako izgraditi otpornost građana u digitalnom društvu.]]></summary_hr><summary_en><![CDATA[The goal of this project is to develop and empirically test the conceptual model of resilience of Internet users who have experienced privacy violation online. Developing a comprehensive list of antecedents and adaptive responses to online consumer resilience will be based on cross-disciplinary examination of literature on resilience and consumer behavior online in order to define variables in the model. Collating dispersed concepts of resilience and integrating contemporary consumer behavior approaches will provide a rationale background for developing a theoretical framework of online consumer resilience. Project will develop and validate the unique measurement instrument that would ensure the successful testing of the entire research model on the survey data collected on the net sample of 1000 Internet users who experienced online privacy breach. The relations between variables in the model will be analysed by structural equation modelling. Further, technical security aspects online and perceived risk in resilience and consumer behavior context, typology of internet users who experienced privacy online breach, as well as consumer resilience to online privacy violation and digitalization in public sector will be investigated. The wrap-up of all findings will lead to the final model of online consumer resilience. Research will reconcile segmented and controverting findings of previous studies, identify recent trends in this line of research across disciplines, and produce theoretical and empirical framework for further applicative research in social sciences. Implications and policy recommendations derived from the research would benefit business community to develop effective business strategies. Important impact is seen in raising public policy makers’ awareness on importance of protecting privacy online and in providing answers how to build the resilience of citizens in the digital society.]]></summary_en></project><project>
<id>8610</id><title_hr><![CDATA[Predobro da bi bilo istinito? Učinak turizma na tržište nekretnina u Hrvatskoj]]></title_hr><title_en><![CDATA[Too much of a good thing? The effects of tourism on the housing market in Croatia]]></title_en><user_id>603</user_id><user_firstLast_name>Maruška Vizek</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-7386</code><acronim><![CDATA[TOURCRO]]></acronim><duration>03.02.2020 - 02.02.2024</duration><status>Završio</status><financ_value>39.816,84 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, </scie_field_hr><scie_field_en>Economy, </scie_field_en><institution_hr><![CDATA[Ekonomski institut Zagreb]]></institution_hr><institution_en><![CDATA[Institute of Economics in Zagreb]]></institution_en><team_members_id>25838, 3373, 25826, 1363, 4139, 25892, 865153, </team_members_id><team_members_names><![CDATA[Tajana Barbić, Anita Čeh Časni, Ivana Logar, Josip Mikulić, Nebojša Stojčić, James E. Payne Payne, Josipa Filić, ]]></team_members_names><keywords_hr><![CDATA[cijene rezidencijalnih nekretnina, cijene građevinskog zemljišta, turistička aktivnost, turističke eksternalije, peer-to-peer platforme, prelijevanja]]></keywords_hr><keywords_en><![CDATA[housing prices, building plot prices, tourism activity, tourism externalities, peer-to-peer platforms, regional spillovers]]></keywords_en><summary_hr><![CDATA[Cilj ovog projekta jest istražiti utjecaj turističke aktivnosti na cijene nekretnina, što je tema od rastuće društvene i ekonomske važnosti koja je nedovoljno istražena u literaturi. Fokusirali smo se na Hrvatsku, malu otvorenu ekonomiju koja uvelike ovisi o prihodima od turizma, s turističkom industrijom koja se dominantno temelji na kratkoročnom najmu smještaja, kako bismo istražili utjecaj promjene turističke orijentacije u hrvatskim jedinicama lokalne samouprave (JLS) na cijene apartmana, obiteljskih kuća i građevinskih zemljišta. Budući da je Hrvatska relativno mala zemlja u kojoj je otprilike jedna trećina lokalnih jedinica orijentirana na turističke usluge, dok ostale jedinice lokalne samouprave nemaju izravnu izloženost turizmu, istražujemo karakteristike i modalitete prostornog prelijevanja cijena stanova i cijena obiteljskih kuća u svim jedinicama lokalne samouprave koje su posljedica promjena u turističkoj aktivnosti. Osim toga, zbog svoje povijesne ovisnosti o kratkoročnom najmu smještaja, Hrvatska je idealno područje za procjenu kako promjena ponude turističkog smještaja prema većoj dominaciji privatnih kratkoročnih iznajmljivanja putem digitalnih peer-to-peer platformi utječe na cijene stanova i cijene kuća. Konačno, ispitujemo imaju li vanjski utjecaji na okoliš, koji se mogu pripisati turističkoj aktivnosti, utjecaj na cijene stanova i obiteljskih kuća u hrvatskim jedinicama lokalne samouprave. Kako bismo ostvarili ove ciljeve, konstruirali smo sveobuhvatnu godišnju bazu podataka koja sadrži podatke za svih 557 hrvatskih gradova i općina od 2012. godine do danas, na koju ćemo primijeniti dinamičke i prostorne procjene panel podataka u kombinaciji s hedonističkim cjenovnim modelima. Baza podataka obuhvaća pokazatelje tržišta nekretnina (uključujući medijalnu cijenu stanova, obiteljskih kuća i apartmana), različite pokazatelje turističke aktivnosti i standardne odrednice ponude i potražnje cijena nekretnina.]]></summary_hr><summary_en><![CDATA[The aim of this project is to investigate the impact tourism activity exerts on house prices; a topic with increasing social and economic relevance which thus far has been scarcely addressed in the literature. We focus on Croatia, a small open economy highly dependent on tourism revenues with a tourism industry based dominantly on short-term rental accommodation, in order to investigate how changes in tourism orientation in Croatian local government units (LGUs) influences the prices of apartments, family houses, and building plots. Since Croatia is a relatively small country in which approximately one third of LGUs are oriented toward tourism services, while the rest of LGUs have no direct exposure to tourism, we explore the characteristics and modalities of spatial spillovers of apartments and family houses price across all LGUs due to changes in tourism activity. In addition, due to its historic dependence on short-term rental accommodation, Croatia is an ideal laboratory to assess how the change of the tourist accommodation supply towards the dominance of private short-term rentals offered through digital peer-to-peer platforms affects apartment and house prices. Lastly, we examine whether environmental externalities that can be attributed to tourism activity exhibit an impact on apartment and family house prices in Croatian LGUs. In order to achieve these tasks we build a comprehensive annual database containing data for all 557 Croatian cities and municipalities from 2012 to present, and apply dynamic and spatial panel data estimation methods coupled with hedonic price models. The database encompasses housing market indicators (including median prices of apartments, family houses and apartments), various indicators of tourism activity and standard supply- and demand-side determinants of house prices. ]]></summary_en></project><project>
<id>8616</id><title_hr><![CDATA[Modeliranje i praćenje iskustvene kvalitete imerzivnih višemedijskih usluga u 5G mrežama]]></title_hr><title_en><![CDATA[Modeling and Monitoring QoE for Immersive 5G-Enabled Multimedia Services ]]></title_en><user_id>3964</user_id><user_firstLast_name>Lea Skorin-Kapov</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-9793</code><acronim><![CDATA[Q-MERSIVE]]></acronim><duration>08.01.2020 - 07.01.2024</duration><status>Završio</status><financ_value>129.802,91 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Interdisciplinarne tehničke znanosti, Elektrotehnika, Grafička tehnologija, Računarstvo, </scie_field_hr><scie_field_en>Interdisciplinary technological sciences, Electrical engineering, Graphics technology, Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>932, 2626, 23923, 23984, 26399, 6704, 21062, 25517, 26403, 2775, 25539, 866670, </team_members_id><team_members_names><![CDATA[Maja Matijašević, Igor Sunday Pandžić, Lidija Mandić, Nina Pavlin-Bernardić, Sabina Baraković, Dunja  Vučić, Irena Oršolić, Ivan Bartolec, Ana Agić, Mirko Sužnjević, Sara Vlahović, Krunoslav Tržec, ]]></team_members_names><keywords_hr><![CDATA[modeliranje i praćenje iskustvene kvalitete, virtualna i proširena stvarnost, mobilne videokomunikacijske usluge, 5G, strojno učenje]]></keywords_hr><keywords_en><![CDATA[modeling and monitoring QoE, virtual and augmented reality, mobile videocommunication services, 5G, machine learning]]></keywords_en><summary_hr><![CDATA[Ubrzan razvoj u području telekomunikacija i mreža, temeljen na migraciji prema arhitekturama pete generacije (5G), utire put novim mogućnostima pružanja usluga. Predviđa se ostvarivanje niza novih slučajeva uporabe višemedijskih usluga s visokim zahtjevima na kašnjenje, pouzdanost i širinu pojasa, koji će postati sastavni dio svakodnevnog života ljudi. Primjeri uključuju napredne imerzivne aplikacije poput virtualne i proširene stvarnosti (engl. Virtual/Augmented Reality, VR/AR), igranja te strujanja videa ultra-visoke razlučivosti i s 360 stupnjeva. Skup aplikacija koje koriste VR/AR tehnologije zasigurno će se proširiti, te će uz rano usvojene primjene kao što je igranje uključiti i niz aplikacija za poboljšavanje društvenih iskustava, primjene u zdravstvu i obrazovanju ili u profesionalnim i industrijskim slučajevima. Uzevši u obzir kompleksnost takvih usluga, dostupnost novih uređaja, te nove domene primjene, istraživačka zajednica je suočena s izazovima istraživanja novih metodologija, modela i metrika koje bi omogućile razumijevanje i mjerenje iskustva krajnjeg korisnika. Istraživanje iskustvene kvalitete (engl. Quality of Experience, QoE) je stoga tijekom proteklih godina postalo istaknuto pitanje kojim se bave mrežni operatori i davatelji usluga. Adresiranje navedenih istraživačkih izazova inherentno zahtjeva multidisciplinaran pristup. Projekt Q-MERSIVE stoga u istraživačkom timu kombinira komplementarne ekspertize iz područja inženjerstva i mreža, dizajna sučelja/sustava i psihologije kako bi se ostvarili sljedeći ciljevi: 1) razvoj novih modela iskustvene kvalitete za imerzivne umrežene AR/VR 5G aplikacije i mobilne višekorisničke videokomunikacijske usluge, te 2) razvoj novih rješenja za praćenje iskustvene kvalitete i različitih pokazatelja performansi iz perspektive mreže, koristeći kao temelj razvijene modele iskustvene kvalitete. Rješenja će se temeljiti na tehnikama strojnog učenja, ali i analitičkim pristupima, ovisno o primjenjivosti.]]></summary_hr><summary_en><![CDATA[Rapid developments in the telecommunications and networking communities, centered around the migration towards 5G architectures, are paving the way towards new service delivery opportunities. A wide range of advanced applications are expected to become an integral part of people’s everyday lives, with examples including immersive applications, such as virtual reality (VR), augmented reality (AR), gaming, and ultra-high-definition/360-degree video streaming, requiring unprecedented high access speeds, fast rendering, and in certain cases ultra-low latency. Applications leveraging VR/AR technologies will likely go beyond early adopters such as gaming, to enhancing social experiences, healthcare, education, or being used in professional and industrial use cases. Given the complexity of such services, the availability of new hardware on the market, and new application domains, the research community is faced with the challenges of exploring new methodologies, models, and metrics to measure the end user experience. Quality of Experience (QoE) research has thus received much attention over the past years and has become a prominent issue addressed by network, service, and content providers. Addressing these research challenges inherently calls for a multidisciplinary approach. The Q-MERSIVE project combines complementary expertise from engineering and networking, interface/system design, and psychology, to achieve the following overall goals: 1) to propose novel QoE models for immersive 5G-enabled networked AR/VR applications and mobile multi-party conversational video communication services, that map underlying system, context, and user factors to QoE as perceived at the user level, and 2) to propose novel solutions for in-network monitoring of QoE and various Key Performance Indicators, using as a basis developed QoE models. Solutions will rely on machine learning-based techniques, as well as analytical approaches as applicable.]]></summary_en></project><project>
<id>8617</id><title_hr><![CDATA[Alosterički komunikacijski putevi u oligomernim enzimima]]></title_hr><title_en><![CDATA[Allosteric communication pathways in oligomeric enzymes]]></title_en><user_id>424</user_id><user_firstLast_name>Zoran Štefanić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-6764</code><acronim><![CDATA[ALOKOMP/ALOCOMP]]></acronim><duration>01.01.2020 - 31.05.2024</duration><status>Završio</status><financ_value>120.804,30 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, Matematika, Fizika, Biologija, Interdisciplinarne prirodne znanosti, </scie_field_hr><scie_field_en>Chemistry, Mathematics, Physics, Biology, Interdisciplinary natural sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>690, 3091, 25793, 7187, 2999, 863807, </team_members_id><team_members_names><![CDATA[Ivana Leščić Ašler, Aleksandra  Maršavelski, Alessandro Pandini, Bojana Dalbelo Bašić,  Agnieszka  Bzowska, Boris Gomaz, ]]></team_members_names><keywords_hr><![CDATA[alosterija, kristalografija, enzimska kinetika, molekulska dinamika, baze podataka, strojno učenje ]]></keywords_hr><keywords_en><![CDATA[allostery, crystallography, enzyme kinetics, molecular dynamics, databases, machine learning]]></keywords_en><summary_hr><![CDATA[Vjeruje se da alosterija (promjena svojstava enzima na jednom dijelu uzrokovana nekom drugom promjenom na udaljenom mjestu) igra ključnu ulogu u mehanizmu, aktivaciji i inhibiciji, te je od najveće važnosti za funkcioniranje enzima. No usprkos velikom značaju alosterije, njezin mehanizam je još uvijek nepoznat kod većine enzima. Unutar ovog projekta tom će se problemu pristupiti na inovativan način, kombinirajući nekoliko po sebi različitih metoda rijetko korištenih skupa u ovom kontekstu. Same 3D strukture enzima koje nam daje kristalografija rentgenskih zraka (XC), nisu u stanju objasniti u osnovi dinamičku sliku alostrije, te će one biti korištene kao polazne točke za molekulske simulacije (MD). Tako dobivene statičke (XC) i dinamičke (MD) slike enzima biti će povezane u obliku relacijske baze podataka. U ovom obliku te slike će biti idealne za pronalaženje skrivenih veza (putova) između različitih dijelova enzima, što i jest osnova alostrije. Zbog iznimne složenosti i količine podataka u takvoj bazi, u ovom projektu će se pribjeći algoritmima strojnog učenja (ML) koji će obrađivati ove visoko strukturirane podatke. Dakle glavni znanstveni cilj ovog projekta je objasniti mehanizam alosterije u oligomernim enzimima koristeći inovativni pristup u kojem se kombinira informacije dobivene različitim tehnikama: XC, MD i ML. Uz sam mehanizam alosterije unutar projekta će se pokušati razumjeti uloga oligomerizacije u svezi s alosterijom. U konačnici, pronađeni mehanizam alosterije biti će eksperimentalno potvrđen mutiranjem najvažnijih amino-kiselina u alosteričkim putovima pronađenim upotrebom ML algoritama te analizom promjene enzima do kojih dovode te mutacije. To će dati konačan dokaz valjanosti koncepta i algoritama te omogućiti njihovu primjenjivost u širem kontekstu drugih enzima.]]></summary_hr><summary_en><![CDATA[It is believed that allostery (a change in enzyme behaviour in one place caused by some other change at a distant location) plays a key role in enzyme mechanism, activation and inhibition, and is of paramount importance in enzyme functioning. In sharp contrast with its significance, the mechanism of allostery is still poorly understood in most enzymes. Current proposal will try to tackle this problem in a innovative way, by combining several very different methodologies that have seldom been used together in this context. As the 3D structure coming from X-ray crystallography (XC) alone is not capable to explain a fundamentally dynamic basis of allostery, it will serve as a basis for molecular dynamics (MD) simulations. Resulting static (XC) and dynamic (MD) data will be unified in a form of relational database. This database will be ideally suited for identifying hidden connections (pathways) between different enzyme regions, which is the basis of allostery. To address the complexity and the amount of data contained in the database, this proposal will leverage machine learning (ML) algorithms that will operate on this highly structured data. Therefore, the overall scientific objective of the project is to uncover the mechanism of allostery in oligomeric enzymes using a novel approach that combines the information obtained by different techniques: XC, MD and ML. Along with the mechanism of allostery, the project will try to understand the role of oligomerization in connection with allostery. Finally, the proposed allosteric mechanisms will be experimentally validated by mutating the most important residues in allosteric pathways found by ML algorithms and observing the change in enzyme behaviour upon mutations. This will then represent an ultimate proof of the validity of the concept and algorithms found in this project and show great prospect for their applicability in much broader domain of other enzymes. ]]></summary_en></project><project>
<id>8619</id><title_hr><![CDATA[Sekundarno omatanje i izlazak beta-herpesvirusa iz stanice]]></title_hr><title_en><![CDATA[Beta-herpesvirus secondary envelopment and egress]]></title_en><user_id>6604</user_id><user_firstLast_name>Pero Lučin</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-3582</code><acronim><![CDATA[AsCoSE&E]]></acronim><duration>01.01.2020 - 31.12.2023</duration><status>Završio</status><financ_value>177.972,99 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Medicine]]></institution_en><team_members_id>6883, 6891, 6187, 3540, 6963, 26289, 21237, 21236, 26551, 21238, 26801, 26855, 861733, 585, </team_members_id><team_members_names><![CDATA[Hana  Mahmutefendić, Gordana Blagojević Zagorac, Kristina Grabušić, Sandra Kraljević Pavelić, Ljerka Karleuša, Natalia Jug Vučko, Marina Marcelic, Silvija Lukanović Jurić, Valentino Pavišić, Igor Štimac, Messerle Martin, Zsolt Ruzsics, Ivona Viduka, Tamara Gulić, ]]></team_members_names><keywords_hr><![CDATA[beta-herpesvirus, citomegalovirus, odjeljak za sklapanje viriona, sekundarno omatanje viriona, izlazak virusa]]></keywords_hr><keywords_en><![CDATA[beta-herpesvirus, cytomegalovirsu, assembly compartment, secondary envelopment, virion egress]]></keywords_en><summary_hr><![CDATA[Beta-herpesvirusi opsežno reorganiziraju membranski sustav stanice domaćina i iskorištavaju ga za završne faze u proizvodnji virusa: stjecanje virusne ovojnice i izlazak virusa iz stanice. Mjesto i mehanizmi tih procesa su nejasni zbog nedovoljno razjašnjene složenosti membranskog sustava, nedovoljno razvijenih metoda za kvantifikaciju otpuštenih viriona, te nemogućnosti praćenja pojedinačnog virusa i/ili organele unutar stanice. U ovom projektu koristiti ćemo rekombinante mišjeg citomegalovirusa (MCMV), člana beta-herpesvirus obitelji, za poboljšanje metoda kvantifikacije izvanstaničnih viriona, razlikovanje virusne replikacije od proizvodnje virusa te unutarstanično praćenja virusa. Rekombinantni MCMV s fluorescentno-obilježenim malim kapsidnim proteinom, jedini raspoloživi virusi s označenom kapsidom u obitelji beta-herpesvirusa, omogućit će analizu kolokalizacije i dinamičko praćenje virusa tijekom procesa stjecanja ovojnice. S obzirom na to da je izlazak CMV iz stanice rijedak događaj, koristit ćemo digitalnu holotomografsku mikroskopiju (DHTM) kako bismo pratili izlazak MCMV-a iz stanice i razvili test za proučavanje procesa izlaska. Korištenjem sustavnih pristupa, kao što su analiza lokalnog interaktoma pomoću računalnih metoda i BioID testa (proximity-dependent biotin-identification assay), analiza transcriptoma i linearnih motiva u virusnim proteinima, usredotočit ćemo se na značajne stanične čimbenike koji kontroliraju procese virusnog omatanja i izlaska. Značajne čimbenike testirat ćemo pomoću novorazvijenih metoda za  siRNA skrining u dva koraka te identificirati one koji su neophodni za završne faze sazrijevanja virusa. Kako bi stekli mehanicistički uvid, pomoću poboljšane metodologije i knock-down metodama (siRNA) u zaraženim stanicama, dubinski ćemo analizirati male GTPaze iz obitelji Rab i/ili Arf koje kontroliraju svaki od tih procesa.]]></summary_hr><summary_en><![CDATA[Beta-herpesviruses extensively reorganize the membranous system of the host cell which is exploited for the final stages of virus manufacturing, the secondary envelopment and virion egress. The site and mechanisms of these processes remain unresolved due to the unrevealed complexity of the membranous system, insufficiently developed methods for quantification of released virions, and inability of single virus- and/or organelle-tracking inside the cell. In this project we will use recombinants of the murine cytomegalovirus (MCMV), a member of the beta-herpesvirus family, to improve methods of extracellular virus quantification, distinguishing virus replication from production, and virus tracking. Recombinant MCMVs with fluorescently tagged small capsid protein (SCP), the only available capsid-tagged viruses in the beta-herpesvirus family, will enable colocalization analysis and time-lapse tracking during processes of the secondary envelopment. Given that the CMV egress is a rare event we will use digital holotomographic microscopy (DHTM) to track MCMV egress and to develop an assay for egress monitoring. Using systems approaches, such as analysis of local interactome using computational methods and proximity-dependent biotin identification assay, analysis of transcriptome and linear motif mimicry, we will focus to significant host-cell factors that control the processes of envelopment and egress. The significant host-cell factors will be screened using the newly developed two-step siRNA screening assays and those that are essential for the final stages will be identified. To gain mechanistic insights, a small GTPase from Rab and/or Arf family that controls each of these processes will be analyzed in-depth using the improved methodology and knock-down in infected cells. The data obtained will serve for construction of the roadmap of cellular changes required for the final stages of beta-herpesvirus maturation and for identification of potential antiviral targets.]]></summary_en></project><project>
<id>8621</id><title_hr><![CDATA[Integracija i dezintegracija Europske unije: Dinamike europeizma i euroskepticizma]]></title_hr><title_en><![CDATA[Integration and disintegration of the European Union: Dynamics of Europeanism and Euroscepticism]]></title_en><user_id>6920</user_id><user_firstLast_name>Nikola Petrović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2019-04</proposal_call><code>UIP-2019-04-2979</code><acronim><![CDATA[IDEU]]></acronim><duration>24.02.2020 - 23.02.2025</duration><status>Završio</status><financ_value>152.431,48 eur</financ_value><scie_area_hr>Društvene znanosti, Humanističke znanosti, </scie_area_hr><scie_area_en>Social sciences, Humanities, </scie_area_en><scie_field_hr>Sociologija, Politologija, Povijest, </scie_field_hr><scie_field_en>Sociology, Political Science, History, </scie_field_en><institution_hr><![CDATA[Institut za društvena istraživanja]]></institution_hr><institution_en><![CDATA[Institute for Social Research in Zagreb]]></institution_en><team_members_id>26719, 5001, 22482, 27360, 855423, 5762, 865111, 865434, 865433, </team_members_id><team_members_names><![CDATA[Stevo Đurašković, Višeslav Raos, Marko Mrakovčić, Ivan Obadić, Filip Fila, Adrijana Martinović, Josip Bilić, Natasza Styczynska, Ivan Roško Roško, ]]></team_members_names><keywords_hr><![CDATA[Europska unija, ideologija, povijesne traume, identitet, integracija]]></keywords_hr><keywords_en><![CDATA[European union, ideology, historical grievances, identity, integration]]></keywords_en><summary_hr><![CDATA[Dezintegracija Europske unije izuzetno je aktualno i u sve većoj mjeri istraživano pitanje, kako teorijski, tako i empirijski. U ovom će se projektnom prijedlogu kroz interdisciplinarni pristup, te koristeći inovativnu komparativnu metodologiju i za ovu svrhu rijetko korištene sociološke teorije uspoređivati razvoj i dinamiku europeizma i euroskepticizma. Ideje europeizma i euroskepticizma u vrijeme intenzivne društvene polarizacije ključne su u razumijevanju integracijskih i dezintegracijskih procesa. Bit će izvršena kvalitativna komparacija nositelja europeističkih i euroskeptičnih ideja iz političke i intelektualne elite u pet država članica EU-a iz različitih faza proširenja (Njemačka, Ujedinjeno Kraljevstvo, Španjolska, Poljska, Hrvatska), kao i kvantitativna komparacija utjecaja povijesnih trauma na uspjeh euroskeptičnih stranaka u svim državama članicama EU. Rezultati istraživanja bi trebali doprinijeti razumijevanju utjecaja različitih povijesnih iskustava na različite vizije europske integracije u podijeljenim europskim društvima. Komparacija političkih i intelektualnih aktera koji su radili na izgradnji nadnacionalnog identiteta i njihovih protivnika u socijalističkoj Jugoslaviji i EU trebala bi omogućiti dublje razumijevanje integracijskih i dezintegracijskih procesa u nadnacionalnim organizacijama.Pretpostavljeni učinak uspostave istraživačke grupe je razvijanje intenzivnog interdisciplinarnog pristupa u istraživanju europske integraciji u kojem će biti zastupljene sociološke, politološke, povijesne i filozofske perspektive. Istraživačke i diseminacijske aktivnosti trebale bi doprinijeti deideologizaciji rasprave o europskoj integraciji i europskom identitetu u znanstvenom i javnom prostoru.]]></summary_hr><summary_en><![CDATA[Disintegration of the European Union is a highly relevant research question, which has been recently analysed through innovative theoretical and empirical approaches. This project proposal aims to apply an interdisciplinary approach, innovative comparative methodology and for this purpose rarely used sociological theories in order to compare the development of Europeanism and Euroscepticism.  Europeanism and Euroscepticism are ideas that are crucial for understanding integration and disintegration of the EU. Qualitative comparison of carriers of Europeanist and Eurosceptic ideas from political and intellectual elites in five EU member states representing different enlargement phases (Germany, the United Kingdom, Spain, Poland, Croatia) and quantitative comparison of the effects of historical grievances on electoral results of Eurosceptic parties in all EU member states should contribute to the understanding of the influences of diverse historical experiences on different visions of European integration in divided European societies. Comparison of political and intellectual elites that were trying to build supranational identities and their adversaries in socialist Yugoslavia and in the EU should contribute to a better understanding of integration and disintegration processes in supranational organizations. Another impact of this project proposal should be the establishment of a new research group that will develop an intensive interdisciplinary research approach (sociological, political science, historical and philosophical perspectives) to studying European integration. Research and dissemination activities should contribute to deideologization of scholarly and public debates on European integration and European identity. ]]></summary_en></project><project>
<id>8625</id><title_hr><![CDATA[Osnaživanje financijske sposobnosti mladih potrošača kroz programe edukacija i bihevioralne intervencije]]></title_hr><title_en><![CDATA[Empowering financial capability of young consumers through education and behavioural intervention]]></title_en><user_id>26534</user_id><user_firstLast_name>Andrea Lučić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2019-04</proposal_call><code>UIP-2019-04-3580</code><acronim><![CDATA[EfFICAcY]]></acronim><duration>01.02.2020 - 31.07.2025</duration><status>Završio</status><financ_value>165.455,97 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, </scie_field_hr><scie_field_en>Economy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Ekonomski fakultet u Zagrebu]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Economics and Business]]></institution_en><team_members_id>3285, 190, 23666, 3372, 858353, 855349, 855350, 25499, </team_members_id><team_members_names><![CDATA[Dajana Barbić, Ivan Balabanić, Nikola Erceg, Irena Palić, Marija Uzelac, Dora Gaćeša, David Skala, Ružica Brečić, ]]></team_members_names><keywords_hr><![CDATA[FInancijska sposobnost, Profili potrošača, Financijska edukacija, Bihevioralne intervencije, Mladi punoljetni, Panel istraživanje, Kvazi eksperiment]]></keywords_hr><keywords_en><![CDATA[Financial capability, Consumer profiles,  Financial education,  Behavioural interventions, Young adults, Panel study,  Quasi-experiment]]></keywords_en><summary_hr><![CDATA[Okolina u kojoj pojedinci danas donose financijske odluke složena je, promjenjiva i pruža malo mogućnosti za učenje. Odluke potrošača vezane za potrošnju, štednju i ulaganje određuju njihovu osobnu dobrobit kao i stabilnost cjelokupnih ekonomskih sustava. Mladima je posebno potrebna zaštita, jer donose obvezujuće financijske odluke sve ranije, imaju jednostavan pristup financijskim uslugama bez odgovarajućih navika, stavova ili financijske pismenosti. Naglašavajući važnost mutidisciplinarnog pristupa tematici, ciljevi ovog projekta su: 1. Istražiti domene i razviti mjerni instrument za financijsku sposobnost mladih punoljetnih potrošača2. Istražiti razinu financijske sposobnosti mladih punoljetnih potrošača longitudinalno i relevantne čimbenike utjecaja3. Utvrditi profile mladih potrošača prema financijskoj sposobnosti4. Razviti programe edukacije i bihevioralne intervencije s ciljem osnaživanja financijske sposobnosti mladih punoljetnih potrošača5. Ispitati učinkovitost edukativno-bihevioralnih intervencija na različitim profilima mladih prema financijskoj sposobnosti6. Razviti novi teoretski okvir, regulatorne preporuke kao i kurikulum za stvaranje financijske sposobnosti i zaštite mladih potrošača. Projekt će započeti s kombiniranim metodama istraživanja u utvrđivanju domena financijske sposobnosti i razvoju mjernog alata. Temelji se na longitudinalnoj studiji internetskog panela kako bi se pratila dinamika promjene financijske sposobnosti mladih odraslih potrošača. Efikasnost razvijenih edukativno-bihevioralni programi bit će testirana u odnosu na različite profile potrošača, sudionika u internetskom panelu. Projekt će pridonijeti podizanju svijesti o nužnosti koherentnog multidisciplinarnog pristupa razvoju financijske sposobnosti mladih. Kroz detaljno i multidisciplinarno razumijevanje složenosti financijskog ponašanja mladih odraslih potrošača ovaj će projekt pridonijeti ukupnoj kvaliteti zaštite potrošača i razvoju financijskog obrazovanja. ]]></summary_hr><summary_en><![CDATA[The environment in which people make their financial decisions is nowadays complex, volatile, and providing little opportunity for learning. Consumer decisions connected to spending, saving and investing determine their personal well-being and the stability of the economic systems. Young are particularly in need of protection, as they make binding financial decisions at younger age and have easy access to financial services without adequate habits, attitudes or financial literacy. The goals of this project are to:1.	To explore the domains and establish the measurement of financial capability among young adults2.	To investigate the level of financial capability of young adults longitudinally and the factors that influence it3.	To determine financial capability profiles of young consumers4.	To develop educational program and behavioural interventions to build financial capability of young adults5.	To test the effectiveness of educational-behavioural interventions on different financial capability profiles6.	To develop new theoretical framework, regulatory recommendations and educational curricula for building consumer financial capability and protection The project will start with the mixed-method approach in the exploration of financial capability and the development of measurement tool. It is based on the longitudinal opt-in online panel study, tracking the young adults’ financial capability dynamics of change. The developed financial educational-behavioural program will be tested for its effectiveness in the quasi experiment in the online panel, especially concerning different consumer profiles of participants. The project should to contribute to raising awareness of the necessity of a coherent multidisciplinary approach to financial capability. With the in-depth understanding of the complexity of financial behaviour of youth through time this project will contribute to the overall quality of consumer protection and the development of financial education. ]]></summary_en></project><project>
<id>8633</id><title_hr><![CDATA[(Novi) etički i društveni izazovi digitalnih tehnologija u domeni zdravstvene skrbi]]></title_hr><title_en><![CDATA[(New) Ethical and Social Challenges of Digital Technologies in the Healthcare Domain]]></title_en><user_id>23203</user_id><user_firstLast_name>Anto Čartolovni</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2019-04</proposal_call><code>UIP-2019-04-3212</code><acronim><![CDATA[Digit-HeaL]]></acronim><duration>01.01.2020 - 31.12.2024</duration><status>Završio</status><financ_value>180.401,57 eur</financ_value><scie_area_hr>Humanističke znanosti, Biomedicina i zdravstvo, Društvene znanosti, Tehničke znanosti, Prirodne znanosti, </scie_area_hr><scie_area_en>Humanities, Biomedicine and health sciences, Social sciences, Technological sciences, Natural sciences, </scie_area_en><scie_field_hr>Filozofija, Kliničke medicinske znanosti, Sociologija, </scie_field_hr><scie_field_en>Philosophy, Clinical sciences, Sociology, </scie_field_en><institution_hr><![CDATA[Hrvatsko katoličko sveučilište, Zagreb]]></institution_hr><institution_en><![CDATA[Catholic University of Croatia]]></institution_en><team_members_id>26207, 856295, 858426, 865136, </team_members_id><team_members_names><![CDATA[Maria Kolesarova, Anamaria Malešević, Ana Tomičić, Luka Poslon, ]]></team_members_names><keywords_hr><![CDATA[Digitalne tehnologije, Digitalno zdravlje, Bioetika, Umjetna inteligencija, Veliki podaci]]></keywords_hr><keywords_en><![CDATA[Digital technologies, Digital Health, Bioethics, Artificial intelligence, Big data]]></keywords_en><summary_hr><![CDATA[Zdravstvena skrb više nego ikad pogođena je različitim faktorima primjerice, manjkom obrazovane radne snage i kompleksnošću bolesti što zahtijeva određenu racionalizaciju i efikasnost. Kako bi učinkovito vodila prema povećanju blagostanja i produljenju čovjekova životnog vijeka, ostvarenje toga vidi u razvoju i primjeni digitalnih tehnologija. Upravo zbog toga, ovaj uspostavni istraživački projekt ima namjeru, prije svega, kritički analizirati etičke i društvene implikacije razvoja i primjene pojedinih digitalnih tehnologija (umjetne inteligencije, velikih podataka, digitalne fenotipizacije) u domeni zdravstvene skrbi. Važnost ovog istraživačkog projekta ogleda se u dvojakoj svrhovitosti, koja se manifestira u dvije glavne faze projekta i to prvoj znanstveno-istraživačkoj i drugoj organizacijsko-institucionalnoj, posjedujući međusobno ovisne i povezane ciljeve. Znanstveno-istraživačka faza sastoji se od teorijskog i empirijskog dijela, koji u svojoj sinergiji pružaju kompletnu sliku o etičkoj i društvenoj prihvatljivosti novih tehnologija u sektoru zdravstvene skrbi. Sastoji se od više istraživačkih ciljeva, a prvi među njima jest ispitati i provjeriti postoje li novi etički i društveni problemi ili izazovi u primjeni digitalnih tehnologija u području zdravstva, te mogu li se već postojeći instrumenti, načela i teorije u bioetici i medicinskoj etici nositi s ovim novim tehnologijama ili je zapravo, potrebna njihova određena evolucija u novu disciplinu ili subdisciplinu digitalne medicinske etike ili bioetike. Empirijski dio znanstveno-istraživačkog dijela odnosi se na ispitivanje kvalitativnom i kvantitativnom metodologijom percepcije i prihvaćenosti novih tehnologija točnije iščekivanja, strahova te potencijalnih problema zainteresiranih sudionika liječnika, pacijenata, inženjera i studenata medicine. U svojoj organizacijsko-institucionalnoj fazi projekt ima za cilj osnovati istraživačku grupu i Laboratorij za etiku digitalnih tehnologija u zdravstvu (Digit-HeaL).]]></summary_hr><summary_en><![CDATA[Healthcare today, more than ever before, is affected by many factors from the shortage of an educated labour force, to the complexity of diseases requiring specific rationalisation leading to increased welfare and the prolongation of the human life span, being relevant to the development and use of digital technologies. Therefore, this installation research project aims, primarily, to analyse the ethical and social implications of technological development critically, and use of digital technologies (artificial intelligence, big data, digital phenotyping) in the healthcare domain. The relevance of this project is reflected in its dual purpose developed through two project phases: the first being scientific-research and the second being an institutional-organisational phase. The former comprises the theoretical and empirical part, providing a complete picture of the ethical and social acceptability of these new technologies within the healthcare sector. The project itself comprises more research goals, the first being to investigate and check whether there exist new ethical and social issues or challenges arising from the digital technologies used within healthcare. The second goal is to verify whether the existing instruments, principles and theories in bioethics and medical ethics can be useful in dealing with these new technologies, or, whether they require particular evolution in the form of a new discipline or sub-discipline of digital medical ethics or bioethics. The empirical part refers to the investigation using qualitative and quantitative methodologies to examine the perception and acceptance of these new technologies in terms of the precise expectations, fears and potential issues as perceived by stakeholders: physicians, patients, engineers and medical students. Besides these research goals, this project, in its institutional-organisational phase, aims to establish a research group and found a digital healthcare ethics laboratory (Digit-HeaL).]]></summary_en></project><project>
<id>8638</id><title_hr><![CDATA[Lingvistička geografija Hrvatske u europskome okružju]]></title_hr><title_en><![CDATA[Linguistic Geography of Croatia in the European Context]]></title_en><user_id>3723</user_id><user_firstLast_name>Dunja Brozović Rončević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-3688</code><acronim><![CDATA[LinGeH]]></acronim><duration>01.01.2020 - 30.06.2024</duration><status>Završio</status><financ_value>95.825,87 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filologija, </scie_field_hr><scie_field_en>Philology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zadru]]></institution_hr><institution_en><![CDATA[University of Zadar]]></institution_en><team_members_id>751, 787, 2596, 1486, 26406, 818, 806, 589, 12818, 933, 13025, 869, 12878, 26448, 26454, 26447, 26561, 861495, 856145, 865413, 13303, 865479, 13304, 865486, 19099, 12688, </team_members_id><team_members_names><![CDATA[Mira Menac-Mihalić, Anita Celinić, Silvana Vranić, Martina Bašić, Marija Malnar Jurišić, Anđela Frančić, Marina Marinković, Nikola Vuletić, Ante Jurić, Vesna Zečević, Vladimir Skračić, Mijo Lončarić, Nataša Šprljan, Barbara Buršić-Giudici, Valter Milovan, Suzana Todorović, Tijmen  Pronk, Ivan Magaš, Hrvoje Bazina, Mate Kapović Kapović, Filip Galović, Matija Mužek, Lina Pliško, Ivan Miškulin, Joža Horvat, Marijana Tomelić Ćurlin, ]]></team_members_names><keywords_hr><![CDATA[lingvistička geografija, hrvatska dijalektologija, arealna lingvistika, geolingvistika, Lingvistički atlas Istre, OLA, ALE, ALM]]></keywords_hr><keywords_en><![CDATA[linguistic geography, Croatian dialectology, linguistic atlas, geolinguistics, Linguistic atlas of Istria, OLA, ALE, ALM]]></keywords_en><summary_hr><![CDATA[Temeljni je cilj projekta stvaranje reprezentativnoga jezičnog zemljovida Hrvatske (oko 150 pomno odabranih hrvatskih punktova te desetak punktova hrvatskih govora iz dijaspore) te izradba oglednih digitalnih zemljovida za Lingvistički atlas Istre na temelju kartografske obradbe tridesetak reprezentativnih tema. Tako zahtjevan i složen zadatak može se ostvariti samo stvaranjem snažne istraživačke grupe na području lingvističke geografije kako bi se koordinirala geolingvistička i dijalektološka istraživanja koja se provode u raznim istraživačkim ustanovama u Hrvatskoj. Objedinjavanjem istraživanja oko jednog središnjeg geolingvističkog znanstvenog projekta postići će se sinergijski učinak s ciljem stvaranja reprezentativnog jezičnog zemljovida Hrvatske. Rad na projektu provodit će se suradnjom nekoliko istraživačkih skupina (Zavod za lingvistička istraživanja HAZU, Sveučilišta u Zagrebu, Zadru, Rijeci i Puli, IHJJ) te dvoje suradnika iz Nizozemske i Slovenije. Iako se ovaj projektni prijedlog temelji na tradicionalnim dijalektološkim istraživanjima i uvriježenoj metodologiji lingvističke geografije, u izvedbi će se primjenjivati suvremene metode i tehnike na polju lingvističke geografije, odnosno arealne lingvistike. Jezični će zemljovidi biti georeferencirani, podatci će biti pohranjeni u baze podataka, a samo kartografiranje izvodit će se s pomoću GIS-a. Interpretacija zemljovida koja će se temeljiti na analizi unutarjezičnih i izvanjezičnih čimbenika rasprostranjenosti analizirane jezične pojave predstavlja bitan odmak od tradicionalne lingvističke geografije. Konačno, ovaj je projekt i međunarodno relevantan jer će pojedini suradnici hrvatsku jezičnu građu prezentirati i u okvirima već postojećih europskih projekata lingvističke geografije (Općeslavenski lingvistički atlas – OLA, Europski lingvistički atlas – ALE i Mediteranski lingvistički atlas – ALM) što neprijeporno bitno pridonosi međunarodnoj vidljivosti hrvatske dijalektologije i jezikoslovlja uopće.]]></summary_hr><summary_en><![CDATA[The basic goal of the project is to create a representative language map of Croatia (about 150 carefully selected Croatian points and about ten Croatian points from the diaspora). The second task is to design digital maps for the Linguistic Atlas of Istria based on the cartographic processing of thirty representative themes. Such a demanding and complex task can only be achieved by the creation of a strong research group in the field of linguistic geography in order to coordinate the geolinguistic and dialectological research carried out in various research institutes throughout Croatia. The project will bring together several research groups (at the Linguistic Research Institute of the Croatian Academy, Universities of Zagreb, Zadar, Rijeka and Pula, IHJJ) and two international associates. Consolidating their research into one central geolinguistic research project will offer synergistic benefits and will enable the creation of a representative language map of Croatia. Although this project proposal is based on traditional dialectological research and the established methodology of linguistic geography, contemporary methods and techniques will be applied in the field of linguistic geography. The language maps will be georeferenced, the data will be stored in the database, and mapping will be done using GIS. The essential innovation from traditional linguistic geography is the interpretation of the maps based on an analysis of the internal and external factors that influenced the distribution of linguistic phenomena. Finally, this project is internationally relevant, as some of the associates will present the Croatian language material within the framework of already existing European linguistic projects, such as Slavic Linguistic Atlas – OLA, European Linguistic Atlas – ALE and Mediterranean Linguistic Atlas – ALM. This undoubtedly contributes significantly to the international visibility of Croatian dialectology and linguistics in general.]]></summary_en></project><project>
<id>8639</id><title_hr><![CDATA[Poboljšani model neidealne detonacije gospodarskih eksploziva ]]></title_hr><title_en><![CDATA[An improved model of non-ideal detonation of commercial explosives]]></title_en><user_id>738</user_id><user_firstLast_name>Muhamed Sućeska</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-1618</code><acronim><![CDATA[NEIDEMO]]></acronim><duration>01.01.2020 - 31.12.2023</duration><status>Završio</status><financ_value>117.061,52 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Rudarstvo, nafta i geološko inženjerstvo, Kemijsko inženjerstvo, Strojarstvo, Interdisciplinarne tehničke znanosti, </scie_field_hr><scie_field_en>Mining, petroleum and geological engineering, Chemical engineering, Mechnical engineering, Interdisciplinary technological sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Rudarsko-geološko-naftni fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mining, Geology and Petroleum Engineering]]></institution_en><team_members_id>3171, 23350, 23480, 23273, 23372, 23371, 23464, 23370, 866624, </team_members_id><team_members_names><![CDATA[Mario Dobrilović, Vječislav Bohanek, Vinko Škrlec, Siniša Stanković, Martin Braithwaite, Thomas Klapotke, Miloslav Krupka, Serene Chan, Ivana Dobrilović, ]]></team_members_names><keywords_hr><![CDATA[eksplozivi, neidealna detonacija, numeričko modeliranje, termokemijski izračun, detonacijski parametri]]></keywords_hr><keywords_en><![CDATA[explosives, non-ideal detonation, numerical modeling, thermochemical calculation, detonation parameters]]></keywords_en><summary_hr><![CDATA[Detonacijska svojstva većine brizantnih vojnih eksploziva mogu se pouzdano predvidjeti primjenom Chapman-Jouguet i Zeldovich-von Neumann-Doering-ove hidrodinamičke teorije detonacije. Međutim, ponašanje gospodarskih eksploziva uvelike odstupa od spomenutih teorija. Naime, zbog znatno dužeg vremena trajanja reakcija kod ovih eksploziva, zona kemijskih reakcija je šira a radijalna ekspanzija produkata je značajna. Rezultat toga je znatno manja vrijednost detonacijske brzine u odnosu na teorijski izračunatu,  te izražena ovisnost detonacijskih parametara o promjeru naboja i prisustvu i karakteristikama obloge naboja. Takav oblik detonacije (tzv. „neidealna detonancija“) je složen interdisciplinarni problem koji se opisuje Euler-ovim jednadžbama toka, nadopunjenim jednadžbama za brzinu kemijskih reakcija, te jednadžbama stanja produkata i neizreagiranog eksploziva. Predloženo je nekoliko modela neidealne detonacije, no zbog složenosti problema još uvijek ne postoji dovoljno točan i općeprihvaćeni model primjenjiv na gospodarske eksplozive. Cilj je ovog istraživanja razviti poboljšani model neidealne detonacije koji se temelji na Wood i Kirkwood-ovoj teoriji blago divergentnog toka, sparenoj s termokemijskim računalnim kodom. Glavni istraživački zadaci su: a) prikupiti dovoljan broj eksperimentalnih podataka o detonacijskim svojstvima gospodarskih eksploziva i parametrima koji utječu na detonacijska svojstva, b) razviti poboljšani model brzine reakcija te c) razviti model za opisivanje utjecaja obloge naboja na detonacijska svojstva. Istraživanja će doprinijeti boljem razumijevanju fenomena neidealne detonacije, poglavito razumijevanju procesa u zoni kemijskih reakcija, te utjecaju pojedinih parametara na detonacijska svojstva. Osim toga razvit će se računalni alati koji će omogućiti pouzdanije predviđanje radne sposobnosti gospodarskih eksploziva i doprinijeti razumijevanju interakcije eksploziv/stijena, te pomoći pri izboru eksploziva za zadane geotehničke uvjete.]]></summary_hr><summary_en><![CDATA[The performance of most military high explosives can be accurately predicted applying the Chapman-Jouguet  and Zeldovich-von Neumann-Doering hydrodynamic theories. However, both of these theories often poorly model commercial explosives. Due to longer reaction time of these explosives, reaction zone is wider and radial expansion of products is significant. As a result, measured detonation velocity is lower than predicted.  In addition, their detonation properties strongly depend on charge diameter, and existence and characteristics of confinement. That is why such detonation is called “non-ideal”. The non-ideal detonation is complex interdisciplinary problem that can be described by the Euler flow equations, supplemented by a reaction rate equation, and equations of state of reacted and unreacted explosive. Because of the complexity of the phenomena there is yet no a well-established, generally accepted and accurate enough model of the non-ideal detonation. The aim of this research is to develop an improved non-ideal detonation model based on the Wood and Kirkwood slightly divergent flow theory, coupled with a thermochemical equilibrium code. The main objectives of the research are: I) to gather sufficient experimental data on commercial explosives and parameters that affect detonation behaviour, II) to develop an improved reaction rate model, and III) to develop confinement model. Expected results of the research are: I) better understanding of the non-ideal detonation phenomena, in particular the structure of detonation driving zone and the effects of individual parameters on detonation behaviour, II) more reliable prediction of performance of commercial explosives as a function of charge diameter and confinement characteristics, III) development of reliable computational tools that will help in understanding of the explosive/rock interaction, as well as selection of appropriate explosive for a given geotechnical environment.]]></summary_en></project><project>
<id>8641</id><title_hr><![CDATA[Dekompozicije i aproksimacije matrica i tenzora]]></title_hr><title_en><![CDATA[Decompositions and Approximations of Matrices and Tensors]]></title_en><user_id>13175</user_id><user_firstLast_name>Erna Begović Kovač</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2019-04</proposal_call><code>UIP-2019-04-5200</code><acronim><![CDATA[DAMAT]]></acronim><duration>01.01.2020 - 31.03.2025</duration><status>Završio</status><financ_value>133.758,05 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet kemijskog inženjerstva i tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Chemical Engineering and Technology]]></institution_en><team_members_id>17823, 26259, 858434, </team_members_id><team_members_names><![CDATA[Ivana Šain Glibić, Anita Carević, Ana Boksic Boksic, ]]></team_members_names><keywords_hr><![CDATA[numerička linearna algebra, znanstveno računanje, faktorizacija, aproksimacija, svojstveni problem, algoritmi koji čuvaju strukturu]]></keywords_hr><keywords_en><![CDATA[numerical linear algebra, scientific computing, factorization, approximation, eigenvalue problem, structure-preserving algorithms]]></keywords_en><summary_hr><![CDATA[U modernom svijetu gdje je svakodnevno potrebno obraditi iznimno velike količine podataka važnost razvoja brzih, točnih i robusnih numeričkih algoritama za matrice i tenzore nemoguće je previše naglasiti. Najvažniji i najizazovniji problemi znanstvenog računanja su oni koji uključuju velike količine numeričkih podataka koji se modeliraju velikim matricama ili višedimenzionalnim tenzorima. Ograničenost računalne memorije, kao i činjenica da je do rješenja potrebno doći u što kraćem vremenu postavljaju zahtjeve koji dodatno otežavaju početni problem. Tome se može doskočiti jako dobro osmišljenim algoritmima koji će što efikasnije iskoristiti memoriju računala, a pri tom zadržati visoku relativnu točnost. Neki od načina da se to postigne su iskorištavanje strukture problema, aproksimacije matricama, odnosno tenzorima, nižeg ranga koji zauzimaju bitno manje mjesta u memoriji i rad s matričnom (tenzorskom) dekompozicijom umjesto s polaznom matricom (tenzorom). Naša će se grupa baviti aktualnim područjem numeričke linearne algebre gdje se postavljaju mnoga zanimljiva pitanja, kako ona teorijske naravi, tako i ona vezana uz širok spektar primjena. U teorijskom dijelu istraživanja proučavat ćemo konvergenciju i točnost numeričkih metoda. Upravo takvi teorijski rezultati daju opravdanost razvoju numeričkih algoritama. S numeričkog aspekta bavit ćemo se razvojem novih i poboljšanjima postojećih algoritama. Uz znanstvene radove u visoko indeksiranim međunarodnim časopisima, naše će istraživanje rezultirati s nekoliko paketa u programskom jeziku Julia, novom programskom jeziku razvijenom za znanstveno računanje. Predloženo istraživanje može se podijeliti u sljedećih šest cjelina: Numerički algoritmi za tenzore, Algoritmi za aproksimacije matrica i tenzora koji čuvaju strukturu, Algoritmi za nelinearni svojstveni problem, Primjene matričnih dekompozicija u ultrazvučnoj tomografiji, Metode Jacobijevog tipa za rješavanje svojstvenog problema i Uparene dekompozicije.]]></summary_hr><summary_en><![CDATA[Every day it is necessary to analyse big data sets. Therefore, the importance of fast, accurate and robust numerical algorithms can hardly be overestimated. The most important and the most challenging problems of the scientific computing are those involving very big amount of numerical data modelled by big matrices or multidimensional tensors. Limitations of the computer memory and the fact that we want to obtain the solution fast imply additional requirements to our problems. We can overcome these obstacles by well-created algorithms that efficiently use computer memory while keeping the relative accuracy. Some of the approaches in this direction are using the particular structure of the problem in question, using low-rank approximations of matrices or tensors, and using matrix or tensor decompositions.Our group is going to work on hot topics of numerical linear algebra where many interesting questions are raised, both theoretical ones and those involving various applications. As for the theoretical part, we study convergence and accuracy of the numerical methods. Such results recline the development of the adequate numerical algorithms. For the numerical part we develop new algorithms and improve the existing ones. Apart from the research papers in prestigious international journals, our research will result with a few toolboxes for Julia, a rather new high-performance programming language designed for scientific computing. Proposed research can be split into the following six sections: Numerical algorithms for tensors, Structure-preserving matrix and tensor approximations, Algorithms for the nonlinear eigenvalue problem, Applications of matrix decompositions in ultrasound tomography, Jacobi-type methods for the eigenvalue problem, and Coupled decompositions.]]></summary_en></project><project>
<id>8648</id><title_hr><![CDATA[Pametne usluge usmjerene čovjeku u interoperabilnim i decentraliziranim okolinama Interneta stvari]]></title_hr><title_en><![CDATA[Human-centric smart services in interoperable and decentralised IoT environments]]></title_en><user_id>5079</user_id><user_firstLast_name>Ivana Podnar Žarko</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-1986</code><acronim><![CDATA[IoT4us]]></acronim><duration>01.01.2020 - 30.04.2024</duration><status>Završio</status><financ_value>161.150,71 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, Elektrotehnika, </scie_field_hr><scie_field_en>Computer sciences, Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>2612, 4930, 3681, 5946, 4895, 13399, 26574, 856054, 858432, 865126, 865440, </team_members_id><team_members_names><![CDATA[Gordan Ježić, Mario Kušek, Miljenko Mikuc, Igor Čavrak, Marin Vuković, Denis Salopek, Federico Matteo Benčić, Ivan Čilić, Katarina Mandarić, Dora Kreković, Petar Krivić, ]]></team_members_names><keywords_hr><![CDATA[Internet stvari (IoT), interoperabilnost, sigurnost, privatnost, tehnologija Blockchain, distribuirana digitalna knjiga, kognitivne usluge]]></keywords_hr><keywords_en><![CDATA[Internet of Things (IoT), interoperability, security, privacy, Blockchain, Distributed Ledger Technology, cognitive services]]></keywords_en><summary_hr><![CDATA[Internet stvari (IoT) je identificiran kao revolucionarna tehnologija koja donosi digitalnu transformaciju u mnoga područja te stvara značajan utjecaj na cjelokupno ljudsko društvo. Omogućava ispreplitanje fizičkog i digitalnog svijeta pomoću umreženih uređaja postavljenih u našu okolinu kojima rukuju korisničke aplikacije i usluge, dok njima upravljaju programske platforme. Međutim, semantička i sintaktička nekompatibilnost postojećih platformi ograničava širenje i bolje prihvaćanje IoT-rješenja u praksi te ih ograničava na određene domene ili ogledne projekte. Projekt IoT4us usvaja i nadograđuje aktualne rezultate proizašle iz projekta H2020 symbIoTe tijekom kojega je razvijena međuopremu otvorenog kôda za interoperabilnost Interneta stvari te je uspostavljen početni ekosustav interoperabilnih IoT-platformi, pokrećući tako novi val inovativnih aplikacija i usluga nad različitim domenama i platformama. IoT4us će nastaviti daljnji razvoj tog ekosustav kako bi stvorio interoperabilnu, decentraliziranu, dinamičnu i sigurnu IoT-okolinu koja čuva privatnost korisnika, a pritom se oslanja na računalne resurse na rubu mreže. IoT4us će u takvim dinamičnim okruženjima omogućiti autonomne i kognitivne IoT usluge usmjerene čovjeku i u skladu s potrebama korisnika. Provedeno istraživanje će pridonijeti nastanku IoT-rješenja sljedeće generacije koja su prikladna za mreže 5G, kroz masovno postavljanje IoT-uređaja s osnovnim ciljem ponude praktičnih i sigurnih aplikacija i usluga za krajnje korisnike koje štite njihovu privatnost. Kroz svoje istraživačke ciljeve, projekt će istražiti sljedeće izazovne teme: interoperabilne, dinamičke, decentralizirane i sigurne IoT-ekosustave namijenjene mrežama sljedeće generacije (uključujući mreže 5G), adaptivne komunikacijske protokole za učinkoviti prijenos podataka, inteligentne i kognitivne metode za IoT, tehnologiju Blockchain i mehanizme za očuvanje privatnosti u okolinama Interneta stvari.]]></summary_hr><summary_en><![CDATA[Internet of Things (IoT) is identified as a disruptive technology which brings digital transformation into many domains and creates significant impact on the overall human society. It enables the interweaving of the physical and digital world by means of networked devices placed in our environment that are operated by end user applications and services, while being managed by software platforms. However, semantic and syntactic incompatibilities of existing platforms are limiting a proliferation and higher adoption of IoT solutions in practice by restricting them to specific domains or pilot projects. The IoT4us project is adopting and building upon cutting-edge results of the H2020 project symbIoTe which has developed the Open Source middleware for IoT interoperability and established an initial ecosystem of interoperable IoT platforms steering a new wave of innovative IoT applications and services across different domains and platforms. IoT4us will evolve this ecosystem further to create interoperable, decentralised, dynamic, secure and privacy-preserving IoT environments that, in addition to cloud resources, also rely on edge/fog computing resources. IoT4us will enable human-centric, adaptive and cognitive IoT services and applications in line with user needs in dynamic environments. The performed research will contribute to the emergence of next-generation IoT solutions adequate for 5G networks and massive deployment of IoT devices with a primarily goal to offer practical, secure and privacy-preserving applications and services. Through its research objectives, the project will investigate the following challenging topics: interoperable, dynamic, decentralized and secure IoT ecosystems for next-generation networks (including 5G), adaptable communication protocols for efficient data transmission, intelligent and cognitive methods for IoT, Blockchain technology and privacy-preserving mechanisms for IoT.]]></summary_en></project><project>
<id>8649</id><title_hr><![CDATA[Projekt nedužnosti u Hrvatskoj]]></title_hr><title_en><![CDATA[Innocence Project in Croatia]]></title_en><user_id>5549</user_id><user_firstLast_name>Leo Cvitanović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-9893</code><acronim><![CDATA[CroINOP]]></acronim><duration>01.02.2020 - 31.01.2024</duration><status>Završio</status><financ_value>49.715,31 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Pravo, </scie_field_hr><scie_field_en>Law, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Pravni fakultet u Zagrebu]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Law]]></institution_en><team_members_id>4199, 26073, 26128, 13631, 5073, 6127, 865195, </team_members_id><team_members_names><![CDATA[Marta Dragičević Prtenjača, Damir Primorac, Steven Becker, Dragan Primorac, Sunčana Roksandić Vidlička, Lucija  Sokanović, Andrej Bozhinovski Bozhinovski, ]]></team_members_names><keywords_hr><![CDATA[projekt nedužnosti, obnova postupka, DNK analiza, baze podataka, naknadna vještačenja, privatnost]]></keywords_hr><keywords_en><![CDATA[innocence project, reopening of criminal proceedings, DNA analysis, databases, subsequent expert testimony, privacy]]></keywords_en><summary_hr><![CDATA[U  Hrvatskoj ne postoje tzv. projekti  nedužnosti kojima bi se pogrešno osuđenim osobama (nedužnima) omogućila obnova postupka naknadnim vještačenjem DNK u laboratorijima. Baze DNK podataka u Hrvatskoj za sada se vode jedino pri Centru &#39;Ivan Vučetić&#39;, a važne su jer omogućavaju pohranjivanje DNK podataka koji se zatim mogu koristiti u razne svrhe, pa i u svrhe utvrđivanja (ili oslobađanja) počinitelja kaznenih djela. U tom smislu prijedlog ovog projekta ide u smjeru identificiranja najbolje prakse za obnovu postupka na osnovi provedenih naknadnih DNK vještačenja. Za podnošenje tog zahtjeva, potrebno je i dobro skladištenje, tj. (o)čuvanje predmeta koji sadrže materijalne tragove (corpore), s kojih bi se izuzeo i analizirao DNK materijal (Lee, Palmbach, Primorac, Anđelinović 2014, 253-276; Kay, Bieber, Primorac 2014, 509-525). Ukoliko bi rezultati analize pokazali da bi osoba mogla biti oslobođena, savjetovalo bi joj se podnošenje zahtjeva za obnovom postupka temeljenog na novoj činjenici/dokazu. Ujedno bi se sugeriralo i poduzimanje daljnjih odgovarajućih pravnih mjera. Zainteresirane osobe bi ispunjavale tzv. &#39;pismo namjere&#39; za razmatranjem njihovih slučajeva putem mrežnog obrasca na stranicama projekta i/ili koji bi stizao na adresu &#39;sjedišta&#39; projekta. S tim u vezi bi se istraživale i mogućnosti kompenzacija osobama koje su bile pogrešno osuđene u vidu predlaganja donošenja relevantnog zakona ili pravilnika. Uz navedenu ideju kao temeljnu fokusnu točku, dodatno bi se istraživalo izuzimanje DNK u kaznenom postupku te bi se analizirali spisi predmeta u kojima je bila korištena DNK analiza, kao i broj obnova postupka temeljem ove metode. Provelo bi se i istraživanje o tome izuzima li se DNK u svim slučajevima propisanim čl. 174a ZIKZ. Jedna od istraživačkih točaka bila bi i ispitivanje interesa zatvorske populacije o podnošenju zahtjeva za obnovom postupka temeljem DNK analize, uz utvrđivanje eventualno opravdanih zahtjeva i njihovo daljnje procesuiranje. ]]></summary_hr><summary_en><![CDATA[There are no so-called Innocence Projects in Croatia, through which wrongfully convicted (innocent) persons would have the possibility of motioning for a new trial based on subsequent DNA analysis. DNA databases in Croatia are, so far, stored only with the Ivan Vučetić Centre and are essential because they enable the storing of DNA data which can then be used in different ways, including determining (or liberating) the culprits in criminal offenses. In that vicinity, this project proposal means to identify the best practice for a new trial based on subsequent DNA analysis. For motioning such a request, there is a need for proper storage, i.e., guarding of material evidence (corpore), from which DNA material would be extracted and analyzed (Lee, Palmbach, Primorac, Anđelinović 2014, 253-276; Kay, Bieber, Primorac 2014, 509-525). If the results showed that the person could be freed, he/she would be advised to motion for a new trial based on new evidence. Other applicable legal measures would also be recommended. Interested persons would fill out a so-called ‘’letter of intent’’ for the consideration of their cases via the web form on the project’s site and/or which would arrive by post at the project’s HQ. Means of financial compensation for wrongfully convicted persons using legal or normative acts would be considered. Along with the said idea as the main focal point, additional research would be based around extracting DNA in criminal proceedings and the analysis of case files where DNA analysis was used, as well as the number of new trials based on this method. Research would be conducted as to whether DNA is extracted in all cases proscribed by art. 174 of the ZIKZ. One of the points would be an inquiry into the interest of the prison population related to the motion for a new trial based on DNA analysis, with the determination of possibly legitimate requests and later proceedings. ]]></summary_en></project><project>
<id>8653</id><title_hr><![CDATA[Varijante u repetitivnim strukturama višeg reda u centromernim i NBPF dijelovima genoma čovjeka i viših primata]]></title_hr><title_en><![CDATA[Variants in higher order repeat structures in centromeric and NBPF regions of human and higher primates genomes]]></title_en><user_id>4004</user_id><user_firstLast_name>Matko Glunčić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-2757</code><acronim><![CDATA[HORVAR]]></acronim><duration>01.02.2020 - 31.01.2024</duration><status>Završio</status><financ_value>110.478,47 eur</financ_value><scie_area_hr>Prirodne znanosti, Biomedicina i zdravstvo, Interdiciplinarne znanosti, </scie_area_hr><scie_area_en>Natural sciences, Biomedicine and health sciences, Interdisciplinary scientific area, </scie_area_en><scie_field_hr>Interdisciplinarne prirodne znanosti, Fizika, Biologija, Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Interdisciplinary natural sciences, Physics, Biology, Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>5102, 5356, 22547, 26601, 5282, </team_members_id><team_members_names><![CDATA[Vladimir Paar, Ines Vlahović, Leo Mršić, Hrvoje Jerkovic, Marija Rosandić Pilaš, ]]></team_members_names><keywords_hr><![CDATA[ljudski genom, satelitska DNK, HOR, NBPF, centromera, poremećaji autističnog spektra, točkaste mutacije, varijante u broju kopija, genski regulatori]]></keywords_hr><keywords_en><![CDATA[human genome, satelitte DNA, higher order repeats, centromere, autism spectrum disorder, single point variants, copy number variants]]></keywords_en><summary_hr><![CDATA[Satelitsku DNK karakterizira iznimno veliki broj varijacija među vrstama i pojedincima. Bitno je razumjeti kako i zašto satelitska DNK varira jer su poznate veze između satelita i fenotipova, na primjer, varijacije u broju satelitskih kopija (CNV) povezane su s pojavom tumora, aneuploidijom, starenjem, razlikama u  genskoj ekspresiji te evolucijskim razvojem. Stoga je identifikacija i analiza satelitskih struktura od ključnog interesa.Istaknuti primjer satelitske DNK je alfa satelitska obitelj koja je ključna za različite funkcije centromere, kao što su podjela u mitozi i mejozi, sparivanje homolognih kromosoma, vezanje sestrinskih kromatida te formiranje kinetohore. Uzajamno djelovanje alfa satelitske organizacije i mreže uključene u formiranje centromere i kinetohore za sada je još slabo razumljivo. Cilj 1 predloženog projekta je otkriti mehanizam alfa satelitske organizacije u centromeri, analizirajući različite alfa satelitske nizove i njihove varijante u genomima primata. Rasvjetljavanje ovog mehanizma  pomoći će nam razumjeti ulogu alfa satelita u organizaciji i funkciji centromere, osobito njihovu ulogu u formiranju funkcionalne kinetohore.Poremećaj autističnog spectra (ASD) je kompleksno neurorazvojno stanje karakterizirano smanjenom socijalnom interakcijom i komunikacijskim sposobnostima, kao i povećanim repetitivnim ponašanjem i stereotipnim interesima. Nedavno je identificirana nova proteinska domena, unutar NBPF gena, povezana s ASD-om. Ova domena karakterizirana je s neobično širokim spektrom CNV-ova unutar ljudske populacije. Stoga postoji velika potreba za razvojem napredne strategije za točnu identifikaciju CNV-ova unutar NBPF gena. Cilj 2 predloženog projekta je analiza slobodno dostupnih genomskih sekvenci pojedinaca u AGRE repositoriju u svrhu identifikacije CNV-ove u NBPF genima. Analiza i klasifikacija varijanti u NBPF genima te njihovo povezivanje s fenotipovima ASD-ova pomoći će nam razumjeti genetički mehanizam razvoja raznih tipova ASD-a.]]></summary_hr><summary_en><![CDATA[Satellite DNA shows astonishing variation among species and individuals. It is important to understand how and why satellite DNA varies because there are established links between satellites and phenotypes, for example, satellite copy number variants (CNVs) are associated with cancer outcomes, aneuploidy, aging, differences in gene expression and evolutionary development. Therefore, their identification and analysis are currently of substantial interest.The pronounced example of satellite DNA is the alpha satellite family which is implicated in centromeric functions, such as segregation in mitosis and meiosis, pairing of homologous chromosomes, sister chromatid attachment and formation of kinetochore structures. The interplay between alpha satellite organization and the network involved in chromosome and kinetochore ensemble is poorly understood. Aim 1 of the project is to reveal the mechanism of alpha satellite organization by analyzing the different centromeric alpha satellite structures and its variants within primates. Elucidating the mechanism of alpha satellite generation and its structure will help to understand their role in centromeric organization and function, in particular their role in formation of functional kinetochore.Autism Spectrum Disorder (ASD) is a complex neurodevelopmental condition characterized by impaired social reciprocity and communicative skills. Recently, a new protein domene, within the NBPF genes connected to ASD have been identified. It is characterized with an unusually broad spectrum of CNVs within the human population. Consequently, there is a growing need to develop improved strategies for accurate CNVs determination within NBPF genes. Aim 2 of the project is to anlyse freely avaible whole genomes of individuals in the AGRE repository in order to identify CNVs in NBPF genes.  Analysis and classification of variants in NBPF genes and their linkage to ASD phenotypes will help to understand genetic mechanism of ASDs development.]]></summary_en></project><project>
<id>8655</id><title_hr><![CDATA[Višeskalni problemi u mehanici fluida]]></title_hr><title_en><![CDATA[Multiscale problems in fluid mechanics]]></title_en><user_id>817</user_id><user_firstLast_name>Igor Pažanin</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-1140</code><acronim><![CDATA[MultiFM]]></acronim><duration>01.01.2020 - 30.04.2024</duration><status>Završio</status><financ_value>128.011,15 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>25800, 966, 3683, 5074, 25801, 23697, 858439, 22664, 866674, </team_members_id><team_members_names><![CDATA[Michal Benes, Ivan Dražić, Josipa Pina Milišić, Boris Muha, Marcone Pereira, Ana Radošević, Borja Rukavina, Marko Radulović, Tvrtko Dorešić, ]]></team_members_names><keywords_hr><![CDATA[tanka domena, hrapavi rub, poroelastična stijenka, tok fluida, asimptotičke metode, matematički modeli višeg reda, rigorozno opravdanje    ]]></keywords_hr><keywords_en><![CDATA[thin domain, rough boundary, poroelastic wall, fluid flow, asymptotic methods, higher-order mathematical models, rigorous justification]]></keywords_en><summary_hr><![CDATA[Višeskalni problemi, u kojima se mali (ili veliki) parametar pojavljuje u fizikalnim koeficijentima ili u domeni geometrije koju promatramo, prirodno se pojavljuju u mehanici fluida te ih možemo smatrati svakodnevnim fenomenima (cjevovodi, krvožilni sustav, lubrikacijski uređaji, tokovi u poroznoj sredini, itd). Cilj projekta MultiFM predložiti je i analizirati matematičke modele višeg reda koji opisuju razne višeskalne procese u mehanici fluida. Projekt MultiFM okuplja produktivne istraživače mlađe generacije s značajnom međunarodnom reputacijom i rezultatima u području. Proučavat će se tok fluida u (tankim) domenama čiji su stijenke nepropusne, ali mogu biti i porozne ili čak poroelastične. Namjerava se istraživati efekte hrapavih rubova domene kod problema lubrikacije, te proučavati slabo propusne domene poput porozne sredine. Fluidi koje ćemo promatrati biti će klasični newtonovski fluidi, ali veliku pažnju posvetit ćemo i ne-newtonovskim fluidima (power-law fluidi, mikropolarni fluidi). Fluidi mogu biti u jednoj (tekućoj) fazi, a bavit ćemo se i višefaznim fluidima gdje dvije faze egzistiraju zajedno. Inspirirani primjenama, zadavat ćemo nestandardne, ali fizikalno relevantne rubne uvjete i baviti se raznim fizikalnim procesima koji se prirodno događaju kod fluida. Obzirom da nije moguće analitički odrediti rješenja jednadžbi koja dolaze od originalnih zakona sačuvanja, analiza se bazira na teoretskom proučavanju odgovarajućih parcijalnih diferencijalnih jednažbi. Unfolding metode, tehnike višeskalnih razvoja, entropijske metode, Faedo-Glerkinov pristup biti će korišteni u procesu. Formalno izvedeni modeli opravdat će se teorijskom analizom pogreške i numeričkim simulacijama. Kako su istraživačke teme zahtjevne s matematičke točke gledišta i motivirane primjenama iz stvarnog života, rezultati projekta doprinijet će razvitku matematičke mehanike fluida i pokazati se korisnima za inženjersku praksu također.]]></summary_hr><summary_en><![CDATA[Multiscale problems, in which small (or large) parameter appears either in physical coefficients, or in domain geometry, naturally arise in fluid mechanics and can be considered as the everyday phenomena (pipelines, blood circulation system, lubrication devices, porous medium flows, etc.). The goal of the project MultiFM is to derive and analyse higher-order mathematical models describing various multiscale processes in fluid mechanics. The project gathers internationally recognized and productive researchers of the younger generation with major results in the field. We will address the fluid flow through (thin) domains whose walls are rigid, but also could be porous or even poroelastic. We plan to explore the effects of boundary irregularities on the lubrication problems, and to study the low permeability domains such as porous media. The fluids considered will be classical Newtonian fluids, but most attention will be devoted to non-Newtonain fluids (power-law fluids, micropolar fluids). They can be either in one (liquid) phase but we will also investigate multiphase fluids where two phases exist together. Inspired by the applications, non-standard but physically relevant boundary conditions will be imposed and different physical processes occurring in the fluids will be considered. Since we cannot obtain the solutions of the equations coming from the original conservation laws, the analysis is based on theoretical study of the governing partial differential equations. The unfolding methods, multiscale expansion techniques, entropy-based methods, Faedo-Galerkin approach will be used in the process. Formally derived models will be justified via theoretical error analysis and numerical simulations. Since the research topics are demading from the mathematical point of view and motivated by the real-life applications, the project results will contribute to the development of the mathematical fluid mechanics and prove useful in the engineering practice as well.]]></summary_en></project><project>
<id>8661</id><title_hr><![CDATA[Posljednji neandertalci na razmeđu srednje Europe i Mediterana]]></title_hr><title_en><![CDATA[Last Neandertals on the Crossroads of Central Europe and the Mediterranean]]></title_en><user_id>7676</user_id><user_firstLast_name>Ivor Karavanić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-6649</code><acronim><![CDATA[NECEM]]></acronim><duration>01.04.2020 - 30.06.2024</duration><status>Završio</status><financ_value>79.629,70 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Arheologija, </scie_field_hr><scie_field_en>Archeology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>162, 26240, 19342, 3871, 4229, 1168, 26010, </team_members_id><team_members_names><![CDATA[Slobodan Miko, Natalija Čondić, Nikola Vukosavljević, Fred  Smith, Rory Becker, Ines Krajcar Bronić, Marko Banda, ]]></team_members_names><keywords_hr><![CDATA[neandertalci, rani moderni ljudi, musterijen, orinjasijen, Hrvatska]]></keywords_hr><keywords_en><![CDATA[Neandertals, early modern humans, Mousterian, Aurignacian, Croatia]]></keywords_en><summary_hr><![CDATA[Projektom je predložen opsežan interdisciplinaran pristup, koji uključuje širok opseg stručnjaka, s ciljem prikupljanje novih, raznolikih podataka o srednjem i ranom gornjem paleolitiku Hrvatske. Pomoću terenskog i laboratorijskog rada, projekt će baciti novo svjetlo na biokulturnu evoluciju čovjeka u južnom dijelu srednje Europe i središnjem dijelu Mediterana. To uključuje dobivanje precizne kronologije prijelaza srednjega na gornji paleolitik u kontinentalnoj i jadranskoj Hrvatskoj te potpunije razumijevanje odnosa između neandertalaca i ranih modernih ljudi tijekom prijelaznog razdoblja u srednjoj Europi i na Mediteranu. Nadalje, usporedbom ponašanja neandertalaca između dvije različite paleoekološke zone (kontinentalne i jadranske) otvorit će se jedinstvena perspektiva za tumačenje prilagodbe tih ljudi. ]]></summary_hr><summary_en><![CDATA[A comprehensive interdisciplinary approach is proposed by this project, involving  a wide range of professionals to obtain a variety of new data on the Middle and early Upper Paleolithic of Croatia. Employing both field and lab work, the project will shed new light on human biocultural evolution in south Central Europe and Central Mediterranean. This will involve obtaining a high resolution chronology of the Middle/Upper Paleolithic interface in both continental and Adriatic Croatia and provide a more complete understanding of the relationships between Neanderthals and early modern humans during the transitional period in Central Europe and the Mediterranean. Furthermore, comparison of Neandertal behaviour between two different paleoecological zones (Continental and Adriatic) will contribute a unique perspective on Neandertal adaptations.]]></summary_en></project><project>
<id>8663</id><title_hr><![CDATA[Platinom dekorirane čvrste otopine željezovog i kositrovog oksida za vodikove senzore]]></title_hr><title_en><![CDATA[Platinum decorated iron tin oxide solid solutions for hydrogen gas sensing]]></title_en><user_id>955</user_id><user_firstLast_name>Marijan Gotic</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-1195</code><acronim><![CDATA[HydGasSens]]></acronim><duration>01.02.2020 - 30.06.2024</duration><status>Završio</status><financ_value>129.613,25 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Interdisciplinarne prirodne znanosti, Fizika, Kemija, </scie_field_hr><scie_field_en>Interdisciplinary natural sciences, Physics, Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>3671, 13755, 616, 19125, 13753, 350, 865744, 866594, </team_members_id><team_members_names><![CDATA[Goran Štefanić, Jasmin Forić, Anđela Pustak, Nikola Baran, Goran Dražić, Tanja Jurkin, Izabela Đurasović, Monika Šoltić, ]]></team_members_names><keywords_hr><![CDATA[senzori vodika, kositar, zeljezo, čvrste otopine, XRD, Mossbauer, krmisorpcija, metalni oksidi]]></keywords_hr><keywords_en><![CDATA[hydrogen sensors, tin, iron, solid solution, XRD, Mossbauer, chemisorption, metal oxide]]></keywords_en><summary_hr><![CDATA[Mjerenje koncentracije vodikovog plina je važno u proizvodnji poluvodiča kao i u zrakoplovnoj i metalurškoj industriji. Među razvijenim senzorima vodika, oni koji se temelje na poluvodičkim metalnim oksidima privukli su pozornost zbog svoje relativno visoke osjetljivosti, dugog vijeka trajanja i termičke stabilnosti. U ovom projektu istraživat će se osjetljivost SnO2 i Fe2O3 i Fe2xSn2-2xO4-x uzoraka na plinoviti vodik. Dopiranje SnO2 željezovim ionima uzrokovat će promjene u parametrima jedinične ćelije, dužini kemijske veze, broju kisikovih vakancija i utjecat će na energijski procijep SnO2. Očekuje se da će formiranje čvrste otopine željezovog i kositrovog oksida (Fe2xSn2-2xO4-x) smanjiti radnu temperaturu osjetljivosti na vodik i imati blagotvoran učinak na osjetljivost senzora. Selektivnost prema vodiku poboljšat će se dekoriranjem platine (Pt) na površini sintetiziranih uzoraka. Mikrostrukturna svojstva sintetiziranih metalnih oksida optimizirat će se pomoću bezvodnog željezovog (II) i kositrovog (II) acetata. Dvovalentni kationi Fe (II) i Sn (II) će se oksidirati i hidrolizirati pomoću molekula vode nastalih &#39;&#39;in situ&#39;&#39; u reakciji esterifikacije između acetatnih skupina i etanola. Disperzija Pt klastera na sintetiziranim SnO2 i Fe2O3 i Fe2xSn2-2xO4-x uzorcima će se optimizirati upotrebom Pt (II) acetilacetonatnog prekursora. Ista skupina uzoraka bit će sintetizirana mehanokemijski kugličnim mljevenjem (sinteza u čvrstom stanju) i solvotermalnom sintezom pomoću mikrovalova (engl. bottom-up wet chemistry approach). Upotreba dvije različite tehnike sinteze omogućit će nam da odredimo optimalnu formulaciju čvrste otopine s najboljom Pt-disperzijom kako bismo dobili najbolje senzore vodikovog plina. Ovaj projekt može biti prvi korak u razvoju i proizvodnji novih materijala za senzore plina te u izgradnji komercijalno dostupnog sustava za mjerenje niskih koncentracija plina (senzori plinova).]]></summary_hr><summary_en><![CDATA[The hydrogen gas monitoring is important in numerous applications such as in the semiconductor manufacturing, aerospace applications and metallurgical processes. Among the developed hydrogen sensors, those based on semiconducting metal oxides have attracted attention due to their relative high sensitivity, long lifetime and thermal stability. In this project the hydrogen gas sensing properties of pristine SnO2 and Fe2O3 as well as of Fe2xSn2-2xO4-x solid solutions will be studied. SnO2 doping with iron will cause changes in lattice parameters and bond length, number of oxygen vacancies, and will have an impact on the narrowing SnO2 band gap. It is expected that the formation of iron tin oxide solid solution (Fe2xSn2-2xO4-x) will decrease sensor operating temperature and will have beneficial effect on the synthesized sensors sensitivity. The selectivity to hydrogen will be improved by platinum (Pt) decoration on the surface of synthesized samples. In this project the microstructural properties of synthesized metal oxide supports will be optimised using divalent anhydrous iron(II) and tin(II) acetates. The divalent Fe(II) and Sn(II) metal cations will be oxidised and hydrolysed using water molecules generated “in situ” in the esterification reaction between acetate groups and ethanol. The decoration of Pt clusters on the synthesized Fe2O3, SnO2 and Fe2xSn2-2xO4-x supports will be optimised using Pt(II) acetylacetonate precursor. The same set of samples will be synthesized using ball-milling (solid state synthesis) and microwave assisted solvothermal synthesis (bottom-up wet chemistry approach). Using two different synthesis techniques will enable us to determine the optimal solid solution formulation for the highest Pt-catalyst dispersion in order to accomplish the best hydrogen gas sensing properties. This project may be the first step in the development and production of new gas sensor materials and in the construction of commercially available gas-sensing system.]]></summary_en></project><project>
<id>8667</id><title_hr><![CDATA[Modeliranje šumskih zaliha i tokova ugljika te rizika prema budućim klimatskim scenarijima]]></title_hr><title_en><![CDATA[Modelling Forest Carbon Stocks, Fluxes and Forest Risks under Future Climate Scenarios]]></title_en><user_id>360</user_id><user_firstLast_name>Hrvoje Marjanović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-6325</code><acronim><![CDATA[MODFLUX]]></acronim><duration>01.02.2020 - 31.05.2024</duration><status>Završio</status><financ_value>118.030,39 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Šumarstvo, </scie_field_hr><scie_field_en>Forestry, </scie_field_en><institution_hr><![CDATA[Hrvatski šumarski institut]]></institution_hr><institution_en><![CDATA[Croatian Forest Research Institute]]></institution_en><team_members_id>819, 7033, 843, 17816, 26786, 27351, 855914, 18937, </team_members_id><team_members_names><![CDATA[Maša Zorana Ostrogović Sever, Zoltán BARCZA, Elvis Paladinić, Mislav Anić, Dóra Hidy, Giorgio Alberti, DOROTEJA DIMOSKI, Anikó Kern, ]]></team_members_names><keywords_hr><![CDATA[procesni modeli, vrtložna kovarijanca, CO2 tokovi, kalibracija modela, klimatske promjene, rizik šumskih požara, izvrtci, sitni korijen, C u tlu, C:N]]></keywords_hr><keywords_en><![CDATA[process-based model, eddy covariance, CO2 fluxes, model calibration, climate change, forest fire risk, tree cores, soil carbon, fine roots, C:N ratio]]></keywords_en><summary_hr><![CDATA[Klimatske promjene će utjecati na šume, ali alati, koji bi olakšali procjenu rizika i informirano donošenje odluka temeljeno na razumijevanja biogeokemijskih procesa u šumama, trenutno u Hrvatskoj ne postoje.Cilj MODFLUX-a je osigurati okvir za modeliranje klimatskih promjena koji je prilagođen nacionalnim šumskim ekosustavima i okolišnim uvjetima. Pomoću tehnike model-data-fusion (MDF), kroz iterativni i interaktivni proces usporedbe rezultata modela i izmjerenih podataka, kontinuiranog prilagođavanja parametara modela i moguće modifikacije modela, kalibrirat će se i validirati biogeokemijski procesni model Biome-BGCMuSo za glavne nacionalne šumske ekosustave. U MDF-u će se koristiti dva postojeća neovisna skupa podataka koji će se proširiti podacima iz novih mjerenja. Preciznije, visokofrekventne podaci o tokovima CO2 (EC) sa šumske eksperimentalne stanici u Jastrebarskim lugovima koja je u pogonu od 2008. godine, te baza podataka o sastojinskim značajkama (širina goda, stelja, tlo, sitni korijen) prikupljenih na 250 ploha raspoređenih u kontinentalnoj, alpskoj i mediteranskoj biogeografskoj regiji Hrvatske.Kalibrirani model će poboljšati mogućnosti procjene utjecaja klimatskih promjena na različite tipove šuma u Hrvatskog. Procijenjene promjene u zalihama ugljika u tlu, dobivene kroz MODFLUX, biti će na raspolaganju u izvješćivanju o emisijama stakleničkih plinova u Hrvatskoj. Procjenom rizika šumskih požara u budućim klimatskim scenarijima, MODFLUX će prvi omogućiti donositeljima odluka i široj javnosti uvid u očekivani budući rizika od požara u šumama bogatim dijelovima Hrvatske koji trenutno nisu pogođeni šumskim požarima. Unaprjeđenje postojeće EC stanice osigurat će nastavak međunarodno jedinstvenog istraživanja tokova CO2 u poplavnim šumama hrasta lužnjaka. Rezultati projekta biti će objavljeni u časopisima visokog odjeka, a podaci prikupljeni u okviru projekta bit će učitani u otvorene znanstvene baze podataka.]]></summary_hr><summary_en><![CDATA[Climate change will affect forest but tools, which would facilitate risk assessment and informed decision-making based on understanding undelaying biogeochemical processes in forests, currently do not exist in Croatia. MODFLUX aims at providing a climate change equipped modelling framework that is adapted for national forest ecosystems and environmental conditions. Using a model-data-fusion (MDF) technique, through an iterative and interactive process of comparison of model results and measured data, continuous adjustment of model parameters, and possible modification of the model, we will calibrate and validate a process-based biogeochemical model Biome-BGCMuSo for main national forest ecosystems. In MDF we will use two existing independent datasets which will be expanded with data from new measurements. Namely, a high-frequency eddy covariance (EC) data of CO2 fluxes at forest experimental station in Jastrebarsko operational since 2008, and database of forest strand traits (tree-ring widths, litter, soil, fine roots) collected at 250 plots distributed throughout Continental, Alpine and Mediterranean regions of Croatia. Calibrated model will yield in the improved capacity for the assessment of climate change impact on different forest types. Estimated changes in soil carbon stocks, obtained within MODFLUX, would be available for consideration in Croatia’s GHG reporting. By estimating forest fire risks under future climate scenarios, MODFLUX will be the first to provide to the policymakers, and to the general public, a notion of the expected future fire risks in forest-rich parts of Croatia which are currently not affected by forest fires. Overhaul of the existing EC station will ensure the continuation of the internationally unique research of CO2 fluxes in periodically flooded, pedunculate oak forest. The results will be published in high impact factor journals and data collected within the project will be uploaded to open-accesses scientific databases.]]></summary_en></project><project>
<id>8668</id><title_hr><![CDATA[Vrijednost u zdravstvu: emprijska istraživanja i aplikacija]]></title_hr><title_en><![CDATA[Value in health: empirical exploration and application ]]></title_en><user_id>22489</user_id><user_firstLast_name>Ana Bobinac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2019-04</proposal_call><code>UIP-2019-04-3721</code><acronim><![CDATA[VIHEEA]]></acronim><duration>01.01.2020 - 31.12.2024</duration><status>Završio</status><financ_value>174.288,27 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, Interdisciplinarne društvene znanosti, </scie_field_hr><scie_field_en>Economy, Interdisciplinary social sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Ekonomski fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Economics and Business]]></institution_en><team_members_id>5536, 865238, 858441, 5021, 7568, </team_members_id><team_members_names><![CDATA[Nikolina Dukić Samaržija, Elizabeta Ribarić, Ismar Velić, Iva Mucalo, Luka Vončina, ]]></team_members_names><keywords_hr><![CDATA[Ekonomske evaluacije, zdravstvo, troškovna-učinkovitost, financiranje, zdravstvene koristi, određivanje cijena ]]></keywords_hr><keywords_en><![CDATA[Economic evaluations, healthcare, cost-effectiveness, reimbursement, health-related benefits, pricing ]]></keywords_en><summary_hr><![CDATA[Pitanje koje zdravstvene tehnologije financirati iz ograničenog proračuna ima važne implikacije za društvo. Ekonomske procjene zdravstvenih tehnologija mogu pomoći donositeljima odluka u identificiranju tehnologija koje proizvode relativno više zdravstvenih koristi na određenoj razini troškova, tj. identificirati intervencije s višom isplativošću i time maksimizirati razinu zdravstvenih koristi koje proizlaze iz ograničenog proračuna. Ovaj prijedlog istraživanja ima za cilj (1) unaprijediti metodologiju ekonomskih evaluacija i doprinijeti pravilnom tumačenju rezultata ekonomskih evaluacija zdravstvenih tehnologija (procjenom novčane vrijednosti jedinice zdravstvene koristi u hrvatskoj populaciji); (2) baviti se pitanjem financiranja skupih novih lijekova koji donose male zdravstvene koristi po astronomskim cijenama (istražujući preferencije stanovništva o vrijednosti malih zdravstvenih koristi na kraju života pacijenta, kao i prihvatljivost odnosa između troškova i učinaka posebno skupih onkoloških lijekova) (3) primijeniti novi sustav određivanja cijena koji veže cijene lijekova na vrijednost koju generiraju u različitim sub-populacijama i pokazati njezin utjecaj na proračun Hrvatskog nacionalnog zdravstvenog osiguravatelja. U tu svrhu primijenit ćemo metode za ispitivanje preferencija (kontingentna procjena i eksperiment diskretnog izbora) u velikom reprezentativnom uzorku hrvatske javnosti kao i primijeniti tehnike modeliranja kako bismo utvrdili da li i pod kojim uvjetima cijene temeljene na vrijednosti mogu dovesti do smanjenja cijene skupih lijekova.  ]]></summary_hr><summary_en><![CDATA[The question of which healthcare technology to fund from restricted budgets has important implications for society. Economic evaluations of healthcare technologies can assist decision-makers in identifying technologies that produce relatively more health benefits at a certain level of cost, that is, identify interventions with higher cost-effectiveness and hence maximize the level of health benefits produced from the restricted healthcare budget. This research proposal aims to (1) address the appropriate interpretation of economic evaluations (by estimating the monetary value of a health gain in the Croatian population); (2) address the issue of funding expensive new medicines which bring only small benefits at astronomical prices (by exploring populations’ preferences regarding the value of small health gains at the end of patient’s life as well as the trade-off between the costs and effects of expensive medicines) and (3) apply a novel pricing scheme which ties medicine prices to the value they generate in different subpopulations and show its respective impact on the budget of the Croatian National health insurer. To this end, we will apply stated preference methods (contingent valuation and discrete choice experiment) in a large representative sample of the Croatian public as well as apply modelling techniques to discern whether and under which conditions can value-based pricing lead to a reduction in the prices of expensive medicines. ]]></summary_en></project><project>
<id>8671</id><title_hr><![CDATA[Porijeklo i taloženje sedimenata u vrijeme kasno kvartarnih promjena morske razine: Sustav rijeke Krke i Srednjojadranske kotline]]></title_hr><title_en><![CDATA[Sediments between source and sink during a late Quaternary eustatic cycle: the Krka River and the Mid Adriatic Deep System]]></title_en><user_id>162</user_id><user_firstLast_name>Slobodan Miko</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-8505</code><acronim><![CDATA[QMAD]]></acronim><duration>01.12.2019 - 30.11.2023</duration><status>Završio</status><financ_value>138.077,14 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Geologija, Interdisciplinarne prirodne znanosti, </scie_field_hr><scie_field_en>Geology, Interdisciplinary natural sciences, </scie_field_en><institution_hr><![CDATA[Hrvatski geološki institut]]></institution_hr><institution_en><![CDATA[Croatian Geological Survey]]></institution_en><team_members_id>7588, 7552, 26160, 26123, 2732, 5052, 3511, 17774, 7676, 4970, 25947, 6065, 3521, 6839, 26617, 22653, 26653, 6095, 7598, 26705, 855846, 865001, 865216, </team_members_id><team_members_names><![CDATA[Maria Geraga, DIMITRIOS CHRISTODOULOU, Eske Willerslev, Ana Prohaska, Branko Petrinec, Nikolina Ilijanić, Koraljka Bakrač, Dea Brunović, Ivor Karavanić, Ivan Razum, Petra Bajo, Martina Šparica Miko, Valentina Hajek-Tadesse, Ozren Hasan, Božena Mitić, Dario Hruševar, Tatjana Durn, Saša Mesić, George Papatheodorou, Schulz Hartmut, Natalia Šenolt, Ivona Baniček, Alexandros Menegatos, ]]></team_members_names><keywords_hr><![CDATA[promjene morske razine, pleistocene, holocen, srednjojadranska kotlina, paleoklima, geomorfologija podmorja, sedimenti, stratigrafija, aDNA]]></keywords_hr><keywords_en><![CDATA[sea level rise, Pleistocene, Holocene, Mid Adriatic Deep, paleoclimate, sediments, palynology, stratigraphy, marine geomorphology, aDNA]]></keywords_en><summary_hr><![CDATA[This project is set to gain insights and improve the very limited knowledge related to submerged karst paleolandscapes of the Eastern Adriatic Shelf and the Late Quaternary sedimentary sequences along the eastern part of the Mid Adriatic Deep (MAD, Jabuka Pit). The study of the Pleistocene deltaic plains of Krka River will provide an insight into stratigraphic sequence with development of deltaic systems and estuaries, produced by the interplay of eustatic sea level fluctuations and local factors such as sediment supply and tectonic activity. The continuous marine sedimentation during the Late Quaternary will be investigated in the MAD. The role of sediment inflow from Krka River catchment to the Eastern MAD could have been significant during LGM. Using geophysics, sedimentology, micropaleontology, geochemistry and aDNA analysis, the paleoenvironmental evolution will be tracked from fluvial/lacustrine to deeper marine environments, on a short transect less than 100 km in length (Lake Prokljan in the Krka River estuary to Eastern MAD). This suite of analyses will produce climate and environmental proxy data, as well as offer insights into the Late Upper Paleolithic hunters and gatherers migration and environmental adaptation along the Eastern Adriatic coast were a relatively short-lived Krka delta plain probably existed. The dated sea level and landscape changes will help to reconstruct possible human contacts between different regions during Falling, Lowstand and Transgressive System Tracts and decipher the possible role of the Krka River as a land/floodplain bridge. Special attention will be paid to potential anthropogenic environments, recent sedimentation rates and landscape features, as well as determination of fluxes of both organic carbon and terrestrial sedimentary components and potentially toxic elements. ]]></summary_hr><summary_en><![CDATA[Predloženi projekt ima za cilj unaprijediti spoznaje do sada slabo istražene potopljene krajolike istočno-jadranskog šelfa, kao i kasno-kvartarnih sedimenata istaloženih duž istočnog dijela Srednjojadranske kotline (MAD, Jabučka kotlina). Istraživanje pleistocenske naplavne ravnice rijeke Krke dati će uvid u stratigrafski slijed sedimenata s razvojem deltnog sustava i estuarija, koji su nastali interakcijom eustatskih promjena razine mora i lokalnih faktora poput donosa sedimenata i tektonske aktivnosti. Kontinuirana morska sedimentacija tijekom kasnog kvartara, te donos materijala iz slivnog područja rijeke Krke, biti će istražen na prostoru istočnog dijela MAD-a. Primjenom geofizičkih metoda visoke rezolucije, te sedimentoloških, petrofizičkih, geokemijskih, mikropaleontoloških i aDNA metoda na uzorcima iz jezgara sedimenata, po prvi puta će se moći pratiti paleookolišna evolucija od riječnih/jezerskih do dubljemorskih okoliša na profilu kraćem od 100 km (od jezera Prokljan u estuariju rijeke Krke do istočnog MAD-a). Prepoznat će se odgovarajući klimatski i okolišni pokazatelji, te će se dobiti uvid u migraciju i okolišnu prilagodbu lovaca i sakupljača koji su tijekom kasnog paleolitika obitavali na istočnoj obali Jadrana, gdje je vjerojatno postojala naplavna ravnica rijeke Krke. Dobiveni rezultati o promjenama morske razine i krajolika omogućit će razumijevanje moguće interakcije među ljudima sa šireg istraživanog prostora u vrijeme sustavnih traktova padajuće, niske i rastuće razine mora. Time će se istražiti moguća uloga rijeke Krke kao kopnenog/naplavnog „mosta“ za ljudsku migraciju. Posebna pažnja bit će posvećena procjeni recentne brzine sedimentacije, prepoznavanju obilježja potopljenih krajolika, te također izračunu brzine akumulacije organskog ugljika i kopnenih komponenata sedimenata, te potencijalno toksičnih elemenata. ]]></summary_en></project><project>
<id>8675</id><title_hr><![CDATA[Algebre kvantnih struja i njihova teorija reprezentacija]]></title_hr><title_en><![CDATA[Quantum current algebras and their representation theory]]></title_en><user_id>636</user_id><user_firstLast_name>Slaven Kožić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2019-04</proposal_call><code>UIP-2019-04-8488</code><acronim><![CDATA[QuantumCART]]></acronim><duration>01.01.2020 - 30.06.2025</duration><status>Završio</status><financ_value>193.643,90 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>687, 864884, </team_members_id><team_members_names><![CDATA[Marijana Butorac, Marina Sertić, ]]></team_members_names><keywords_hr><![CDATA[kvantne verteks algebre, kvantne afine algebre, glavni potprostori, afine Liejeve algebre, Rogers-Ramanujanovi identiteti, Hopfovi algebroidi]]></keywords_hr><keywords_en><![CDATA[quantum vertex algebras, quantum affine algebras, principal subspaces, affine Lie algebras, Rogers-Ramanujan identities, Hopf algebroids]]></keywords_en><summary_hr><![CDATA[Algebre kvantnih struja predstavljaju fundamentalnu vezu između dva važna područja moderne algebre, kvantnih grupa i kvantnih verteks algebri. Preciznije, javljaju se u realizacijama određenih klasa kvantnih grupa dok, s druge strane, imaju centralnu ulogu u konstrukciji kvantnih verteks algebri. Predloženi projekt će uspostaviti prvu istraživačku grupu iz područja kvantnih verteks algebri u Hrvatskoj. Grupa će se prvenstveno usredotočiti na razvoj teorije algebri kvantnih struja. Glavni cilj je uspostaviti vezu između teorija reprezentacija određenih klasa kvantnih verteks algebri i pripadnih kvantnih grupa. To će rezultirati novim i važnim metodama i alatima čiji širok raspon primjena u različitim područjima matematike planiramo detaljno proučiti. Primjerice, korištenjem koncepta kvazi-modula, dobit ćemo nove rezultate u teoriji algebri refleksija, koje se koriste u matematičkoj fizici za opis integrabilnih sustava s rubnim uvjetima. Nadalje, uvođenjem i proučavanjem pojma glavnog potprostora za određene klase modula algebri kvantnih struja dobit ćemo nove primjere prostih kvantnih verteks algebri, kao i novo okruženje za proučavanje kombinatornih identiteta Rogers-Ramanujanovog tipa. Grupa objedinjuje istraživačke snage članova koji se bave komplementarnim područjima, teorijom kvantnih verteks algebri, teorijom reprezentacija afinih Liejevih algebri i teorijom Hopfovih algebroida, koja su ključna za uspješno provođenje projekta. Doktorandu će iznimno koristiti ovakva istraživačka okolina jer će steći vrijedno iskustvo u tim područjima. Savladavanje najmodernijih metoda i sudjelovanje u razvoju novih alata pripremit će ga da u budućnosti uspješno slijedi vlastite smjerove istraživanja u bilo kojem od njih.]]></summary_hr><summary_en><![CDATA[Quantum current algebras present a fundamental connection between two important areas of contemporary algebra, quantum groups and quantum vertex algebras. More specifically, they occur in realizations of certain classes of quantum groups while, on the other hand, they play a central role in the construction of quantum vertex algebras. The proposed project will establish the first research group in the area of quantum vertex algebras in Croatia. The group will primarily focus on developing the quantum current algebra theory. The main goal is to obtain a correspondence between representation theories of certain classes of quantum vertex algebras and the corresponding quantum groups. This will result in new and important methods and tools whose broad range of applications in various areas of mathematics we plan to further investigate. For example, by employing the concept of quasi module, we will obtain new results in reflection algebra theory, which is used in mathematical physics to describe integrable systems with boundary conditions. Moreover, by introducing and studying the notion of principal subspace for certain classes of quantum current algebra modules, we will obtain new examples of simple quantum vertex algebras, as well as the new framework for studying interpretations of Rogers-Ramanujan-type combinatorial identities. The group combines the research strengths of the members who work in complementary areas, quantum vertex algebra theory, representation theory of affine Lie algebras and theory of Hopf algebroids, which are vital for the successful project implementation. The PhD student will greatly benefit from such research environment as he will gain a valuable experience in these areas. Mastering the cutting-edge methods and participation in the development of new tools will put him in the position where he will have a strong capacity to successfully pursue his own research directions in any of these areas in the future.]]></summary_en></project><project>
<id>8677</id><title_hr><![CDATA[Gluonsko zasićenje u visoko energetskim proton-jezgra sudarima - istraživanje novih fenomenoloških smjernica]]></title_hr><title_en><![CDATA[Gluon saturation in high energy proton-nucleus collisions - exploring new phenomenological directions]]></title_en><user_id>5932</user_id><user_firstLast_name>Sanjin Benić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2019-04</proposal_call><code>UIP-2019-04-5332</code><acronim><![CDATA[SAT-PHENO]]></acronim><duration>02.12.2019 - 01.06.2025</duration><status>Završio</status><financ_value>263.454,77 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>855856, 865052, 868772, </team_members_id><team_members_names><![CDATA[Anton Perkov, Eric Andreas Vivoda, Yoshikazu Hagiwara, ]]></team_members_names><keywords_hr><![CDATA[high energy collision, proton structure, nucleus structure, quantum chromodynamics, gluon, quark, gluon saturation]]></keywords_hr><keywords_en><![CDATA[visoko energetski sudari, struktura protona, struktura jezgre, kvantna kromodinamika, gluon, kvark, gluonsko zasićenje]]></keywords_en><summary_hr><![CDATA[Pojava gluonskog zasićenja modificira spektar i korelacije proizvedenih čestica u sudarima visokih energija. To je temeljno predviđanje efektivne teorije QCD-a na visokim energijama - Color Glass Condensate (CGC). Učinci zasićenja povećavaju se za jezgre i stoga je najbolja opcija razmatranje sudara proton-jezgra. Do sada ne postoje čvrsti eksperimentalni dokazi o gluonskom zasićenju. Kako bismo riješili ovaj problem, predlažemo da istražimo nove CGC observable. Foton i dilepton su posebno obećavajući jer su čista konačna stanja. Njihove fenomenološke implikacije za RHIC i LHC svakako zaslužuju više pozornosti za koje bi ovaj projekt bio vrlo pogodan. Sudaranje poprečno polariziranih protona s jezgrom je još jedan način izučavanja CGC-a jer različiti doprinosi nose različitu nuklearne ovisnost. Paralelno s tim, možemo bolje razumjeti strukturu polariziranog protona. Nedavno su polarizirani sudari p + A postali stvarnost na RHIC-u - za sada je ovo potpuno otvoreno polje te ga stoga svakako vrijedi istražiti. Dobiveni rezultati pružaju temeljni uvid u strukturu protona ili jezgre na visokoj energiji, ograničavaju početne uvjete za A + A sudare i nude kvantitativne smjernice za buduće e + A sudare.U ovom petogodišnjem projektu osnovala bi se istraživačka skupina na Fizičkom odsjeku Prirodoslovno-matematičkog fakulteta Sveučilišta u Zagrebu koja će se sastojati od doktorskog studenta (godina 1-4), dva postdoktoranda (godine 2-3 i 4-5) i mene kao glavnog istraživača. Tijekom svog postdoktorskog usavršavanja u inozemstvu surađivao sam s vrhunskim stručnjacima kako bih napravio nekoliko originalnih radova u ovom području. S kompletnim deficitom CGC stručnjaka u Hrvatskoj ovo je savršena prilika za pokretanje istraživačke CGC skupine. Ovim projektom predstavit će se novo i dinamično istraživačko područje fizičkoj zajednici u Hrvatskoj, uspostaviti nove veze s vrhunskim istraživačkim centrima, čime će se ojačati njezin položaj na znanstvenoj karti svijeta.]]></summary_hr><summary_en><![CDATA[The appearence of gluon saturation modifies the spectrum and correlations of particle production in high energy collisions. It is a fundamental prediction of the high-energy theory of QCD - Color Glass Condensate (CGC). Saturation effects are enhanced for the nuclei and so the best option is to consider proton-nucleus collisions. Up till now there is no firm experimental evidence of gluon saturation. To solve this problem we suggest to explore new CGC observables. Photon and dilepton are especially promising as they are clean final states. Their phenomenological implications for RHIC and LHC definitely deserve more attention for which this project would be very suitable. Colliding transversely polarized protons off a nucleus is another way of constraining CGC as different contributions carry different nuclear dependence. In parallel, we can use it to understand more about the structure of the polarized proton. Recently, polarized p+A collisions have become a reality at RHIC - so far this is a completely open field and so it is definitely worth exploring. The obtained results offer first-principle insight into the structure of the proton or the nuclei at high energy, constrain the initial conditions for A+A collisions and offer quantiative guidelines for future e+A collisions.In this 5 year project a research group would be established at the Physics Department, Faculty of Science, University of Zagreb consisting of a doctoral student (year 1-4), two postdoctoral researchers (year 2-3 and year 4-5) and myself as a principal investigator. During my postdoc abroad I have collaborated with top experts to produce several original works in the field. With a total deficit of CGC experts in Croatia this is a perfect opportunity to start a CGC research group. This project will introduce a young and vibrant research field to the physics community in Croatia, establish new connections with top research centers, strengthening its position on the scientific map of the world. ]]></summary_en></project><project>
<id>8678</id><title_hr><![CDATA[Imunomodulacijski učinci mastocita i eozinofila u mikrookolišu tumora mokraćnog mjehura]]></title_hr><title_en><![CDATA[Immunomodulatory role of mast cells and eosinophils in bladder cancer microenvironment]]></title_en><user_id>5111</user_id><user_firstLast_name>Jelena Korać Prlić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2019-04</proposal_call><code>UIP-2019-04-6680</code><acronim><![CDATA[emBC]]></acronim><duration>01.07.2020 - 30.12.2025</duration><status>U tijeku</status><financ_value>265.445,62 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Split School of Medicine]]></institution_en><team_members_id>5640, 858366, 861753, </team_members_id><team_members_names><![CDATA[Marina Degoricija, Lucija Franković, Ivana Gabela, ]]></team_members_names><keywords_hr><![CDATA[tumor mokraćnog mjehura, mikrookoliš tumora, mastociti, eozinofili, IL-33]]></keywords_hr><keywords_en><![CDATA[bladder cancer, tumor microenvironment, mast cells, eosinophils, IL-33]]></keywords_en><summary_hr><![CDATA[Tumori mokraćnog mjehura su šesti po učestalosti u muškaraca i imaju najveću stopu recidiva među tumorima. Liječenje tumora mokraćnog mjehura intravezikalnom instilacijom BCG cjepiva nakon transuretralne resekcije tumora daje vrlo uspješne rezultate u ranim fazama bolesti, no progresivni i ponavljajući tumori visokog gradusa, postaju otporni na taj oblik liječenja. Imunoterapijsko liječenje uznapredovalih tumora mokraćnog mjehura s PD-1/PD-L1 inhibitorima kontrolne točke pokazuje izvrsne rezultate, ali je ovaj vid terapije učinkovit tek u 20-30% pacijenata. Imunološke stanice su glavna komponenta mikrookoliša tumora, a uspješna primjena BCG cjepiva i inhibitora kontrolne točke ostvaruje svoje pozitivne učinke upravo djelovanjem na imunološke stanice. Mastociti i eozinofili su imunološke stanice redovito prisutne u mikrookolišu tumora mokraćnog mjehura, ali je njihova uloga tamo potpuno nepoznata. Cilj ovog projekta je istražiti ulogu mastocita i eozinofila u nastanku i razvoju tumora mokraćnog mjehura u svrhu poboljšavanja postojećih imunoterapijskih mogućnosti. Ulogu mastocita i eozinofila istraživat ćemo korištenjem mišjeg modela tumora mokraćnog mjehura induciranog kemikalijom N-butil-N-(4-hidroksibutil)-nitrozamin (BBN).  U istraživanju će se koristiti miševi kojima nedostaju mastociti i eozinofili (tzv. knock-out mišji modeli),  neutralizirajuća protutijela za uklanjanje mastocita i eozinofila kao i subkutani model tumora mokraćnog mjehura. Modulacijom učinaka mastocita i eozinofila u mikrookolišu tumora istražiti će se njihov protu-tumorski potencijal. Rezultati ovog projekta unaprijedit će razumijevanje uloge mastocita i eozinofila u tumorigenezi mokraćnog mjehura i pružit će osnove za daljnji razvoj liječenja tih tumora. Izmjena tumorskog mikrookoliša, djelovanjem na mastocite i eozinofile, ima velik potencijal u borbi protiv tumora mokraćnog mjehura koji recidiviraju ili su otporni na postojeće terapije.]]></summary_hr><summary_en><![CDATA[Bladder cancer is the sixth most common cancer in men and has the highest recurrence rate of all cancers. Intravesical therapy with BCG vaccine after the transurethral resection is an exemplary immunotherapeutic strategy for cancer management with a successful outcome in the early stages of the disease. However, progressive and recurrent bladder cancer becomes refractory to BCG. Immune checkpoint inhibitors targeting PD-1/PD-L1 axis were recently introduced in the management of locally advanced and metastatic bladder cancer, but the response rates are confined to 20-30%. Positive effects of BCG and checkpoint inhibitors depend on the activation of immune cells in the bladder cancer microenvironment. Mast cells and eosinophils are immune cells that are commonly found in bladder cancer microenvironment, but their role in bladder cancer pathogenesis remains elusive. Our aim is to investigate the role of mast cells and eosinophils during the initiation and progression of bladder cancer. The role of mast cells and eosinophils will be tested using a mouse model of bladder cancer induced with N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN), in wild type, as well as, in mast cell, and eosinophil knock-out (KO) mice. Furthermore, the role of mast cells and eosinophils will be re-evaluated by their depletion with neutralizing antibodies and by induction of subcutaneous tumors in mice. By modulating mast cell and eosinophil recruitment and activity in bladder cancer microenvironment, we will investigate their role in tumor pathogenesis. Results of this project will help clarify the functions of mast cells and eosinophils in bladder cancer tumorigenesis and will provide a basis for future improvements in bladder cancer immunotherapy.]]></summary_en></project><project>
<id>8691</id><title_hr><![CDATA[GEOloška karakterizacija podzemlja istočnog dijela Dravske depresije s ciljem procjene Energetskog Potencijala]]></title_hr><title_en><![CDATA[GEOlogical characterization of the Eastern part of the Drava depression subsurface intended for the evaluation of Energy Potentials ]]></title_en><user_id>1290</user_id><user_firstLast_name>Marko Cvetković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2019-04</proposal_call><code>UIP-2019-04-3846</code><acronim><![CDATA[GEODEP]]></acronim><duration>17.02.2020 - 16.02.2025</duration><status>Završio</status><financ_value>230.520,83 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Geologija, </scie_field_hr><scie_field_en>Geology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Rudarsko-geološko-naftni fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mining, Geology and Petroleum Engineering]]></institution_en><team_members_id>19181, 12406, 22540, 5613, 5911, 26723, 26640, 856207, 862764, 865522, 867258, </team_members_id><team_members_names><![CDATA[Marko Špelić, Bojan  Matoš, David Rukavina, Iva Kolenković Močilac, Duje Smirčić, Josipa Kapuralić, Ana Kamenski, Marija Pejić, Ana Brcković, Ivan Cindrić, Pegah Soleimani Dinani, ]]></team_members_names><keywords_hr><![CDATA[ugljikovodici, geološko skladištenje CO2, strukturno modeliranje, bazensko modeliranje, podpovršina, Panonski Bazen, Hrvatska]]></keywords_hr><keywords_en><![CDATA[hydrocarbons, geological storage of CO2, structural modelling, basin modelling, subsurface, Pannonian Basin, Croatia]]></keywords_en><summary_hr><![CDATA[Predloženi projekt svojim ciljevima je usklađen s trendom globalnog porasta potreba društva za korištenjem energetskih resursa, pri čemu još uvijek vodeće mjesto zauzimaju nafta i prirodni plin, no uz porast svijesti o potrebi dekarbonizacije energenata, naglašen je i rast potrošnje energije iz obnovljivih izvora. Kroz petogodišnje razdoblje planira se detaljno obraditi izdvojeni dio volumena podzemlja unutar hrvatskog dijela Panonskog bazenskog sustava kao primjera za utvrđivanje energetskog potencijala podzemlja s obzirom na preostale konvencionalne i nekonvencionalne rezerve nafte i prirodnog plina. Također, kao jednu od relevantnih znanstvenih i nacionalnih tema proizašlu iz osviještenosti problema klimatskih promjena i smanjivanja emisija stakleničkih plinova, kroz isto razdoblje procijenit će se potencijal istraživanog područja za geološko skladištenje CO2. Istraživanje je raspoređeno prema godišnjim razdobljima pri čemu su u prve tri godine istraživanja usredotočena na generalnu geološku karakterizaciju podzemlja, temeljenu na interpretaciji postojećih bušotinskih i seizmičkih podataka, kao i na interpretaciji novih podataka prikupljenih terenskim istraživanjima. U posljednje dvije godine ključni elementi (ugljikovodični potencijal i potencijal skladištenja CO2) se izvode iz geološkog modela podzemlja te se provodi diseminacija rezultata kroz konferencije, radionice i publikacije. Kao krajnji rezultat projekta, očekuje se kvantifikacija potencijalnih preostalih rezervi ugljikovodika, izdvajanje potencijalnih zona za iskorištavanje geotermalne energije te procjena mogućnosti geološkog skladištenja CO2 kao i razvoj novih metodologija u istraživanjima.]]></summary_hr><summary_en><![CDATA[The proposed project is aligned with the global trend of growth of the society&#39;s need for energy resources, with oil and natural gas still in leading position, but with highlighted increase of renewable energy consumption due to growing awareness of the need for energy decarbonization. Throughout the five-year period of the proposed research, it is planned to explore the selected part of the subsurface of the Croatian part of the Pannonian Basin System in detail, considering several key aspects. These would involve the definition of the energy potential of the underground with respect to the remaining conventional and unconventional reserves of oil and natural gas. Following one of the relevant scientific and national issues arising from the need for the reduction of greenhouse gas emissions, carbon dioxide storage potential of the research area will be estimated. The research is performed according to annual periods where the first year is most important for the preparation of the project implementation (group formation, equipment procurement, organization of a database of subsurface data and evaluation of the existing situation). The second year is crucial for carrying out field research and construction of the geological model along with establishment of the laboratory. The third year is important from the aspect of field research and characterization of geological relations. The results of the research are finalized in the fourth and fifth year and are dominated by the dissemination of results. The expected results of the project include: quantification of potential remaining hydrocarbon reserves and estimation of potential for geological storage of CO2 in the research area alongside develompment of the new research procedures.]]></summary_en></project><project>
<id>8697</id><title_hr><![CDATA[Kulturna animalistika: interdisciplinarna polazišta i tradicijske prakse ]]></title_hr><title_en><![CDATA[Cultural Animal Studies: Interdisciplinary Perspectives and Traditional Practices]]></title_en><user_id>19264</user_id><user_firstLast_name>Suzana Marjanić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-5621</code><acronim><![CDATA[ANIMAL]]></acronim><duration>01.02.2020 - 31.05.2024</duration><status>Završio</status><financ_value>55.367,97 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Etnologija i antropologija, Filologija, Povijest umjetnosti, Arheologija, Etnologija i antropologija, Interdisciplinarne humanističke znanosti, </scie_field_hr><scie_field_en>Ethnology and anthropology, Philology, Art history, Archeology, Ethnology and anthropology, Interdisciplinary humanities, </scie_field_en><institution_hr><![CDATA[Institut za etnologiju i folkloristiku]]></institution_hr><institution_en><![CDATA[Institute of Ethnology and Folklore Research in Zagreb]]></institution_en><team_members_id>20018, 26167, 20062, 25757, 19516, 26221, 26183, 26236, </team_members_id><team_members_names><![CDATA[Antonija Zaradija Kiš, Maja Pasarić, Lidija Bajuk, Marinka Šimić, Matija Dronjić, Lidija Delić, Marjetka Golež Kaučič, Zvjezdana Jembrih, ]]></team_members_names><keywords_hr><![CDATA[životinja, čovjek, hrvatska etnokultura, zooleksem,  književna animalistika, sakralna animalistička baština, zooarheologija, ekokritika, tezaurus]]></keywords_hr><keywords_en><![CDATA[animal, human, Croatian ethnoculture, zoolexem, literary animal studies, sacral animalistic heritage, zooarchaeology, ecocriticism, thesaurus]]></keywords_en><summary_hr><![CDATA[Projekt ANIMAL temelji se na začecima kulturne animalistike i njenim aktualnim dosezima u Hrvatskoj, na ostvarajima istraživačke kulturnoanimalističke teme IEF-a i na najsuvremenijim svjetskim stremljenjima u tom znanstvenom području. Cilj projekta je istraživanje i obrada etnografske, folklorističke i filološke animalističke građe uz povijesnoumjetničke i arheološke doprinose.  Jedinstven doprinos ANIMAL projekta je u njegovom multidisciplinarnom i interdisciplinarnom pristupu. Navedeno se očituje u razradi ključnih djela starije hrvatske književnosti kroz animalistička očišta, sustavnoj obradi i valorizaciji već postojećih animalističkih podataka u djelima hrvatske etnografije i folkloristike 19./20. st. te na prikupljenoj terenskoj građi pohranjenoj u Dokumentaciji IEF-a što će rezultirati pripremanjem leksikona, Bestijarij hrvatske etnokulture. Inovativnost projekta je prepoznatljiva u razmatranjima najsuvremenijih kulturnoanimalističkih spoznaja u svijetu. Na primjer, kritičke animalistike koja uključuje prava životinja i zooetiku/bioetiku, suvremene zoofolkloristike, etnozoologije i antropologije životinja koje redefiniraju tradiciju kulturnih praksi i promišljaju suživote ljudi i životinja u urbanim prostorima te društvene zooarheologije koja je usmjerena na razumijevanje interakcija čovjeka i životinja u prošlosti. U projektni animalistički korpus po prvi put se uključuje u ekstenzivnijim istraživanjima i povijesnoumjetnička niša kulturnoanimalističkih istraživanja koja se odnosi na prikaze životinja u pučkoj sakralnoj umjetnosti. U kontekstu suvremenih tehnologija inovativnost projekta očitovat će se i u načinu oblikovanja pohranjene građe tj. u modeliranju animalističkog tezaurusa – tehnološki visokosofisticiranome susretištu svih dosadašnjih i budućih animalističkih istraživanja u književnosti, etnologiji, folkloristici, kulturnoj antropologiji i srodnim humanističkim disciplinama.]]></summary_hr><summary_en><![CDATA[ANIMAL builds from the beginnings of cultural animal studies and current animalistic outreaches in Croatia, accomplishments of cultural-animalistic themes’ researched at IEF and contemporary world theoretical tendencies in that scientific area. The objective of the project is research and analysis of the ethnographic, folkloristic and philological animalistic data with art-historical and archaeological contributions. This includes the analysis of the more important works of older Croatian literature from animalistic viewpoints, the systematic analysis and valorization of the existent animalistic data in the capital works of Croatian ethnography and folklore research of the 19th/20th century and the gathered field materials stored in the Documentation of IEF which will result in the preparation of a lexicon with the working title of the Bestiary of Croatian Ethnoculture. ANIMAL also includes reflections on the most current world cultural-animalistic epistemology, e.g. critical animalistics which includes animal rights and zooethics/bioethics, current zoofolkloristics, ethnozoology and anthropology of animals that redefine the tradition of contested cultural practices as well as reflect on cohabitation of people and animals in urban spaces. Unavoidable is the role of social zooarchaeology, directed towards the understanding of interactions of humans and animals in the past and of art historical cultural-animalistic research, the contribution of which will be visible in the presentation of the depiction of animals in religious folk art. In the context of current technologies, the innovativeness of the project will be contained in the way of storing the data, that is, in the modeling of an animalistic thesaurus – technologically highly sophisticated meeting point of all up to current as well as future animalistic researches in literature, ethnology, folkloristics, cultural anthropology and related disciplines of the humanities.]]></summary_en></project><project>
<id>8699</id><title_hr><![CDATA[Količina i struktura biomase obične jele i obične smreke u izmijenjenim klimatskim uvjetima]]></title_hr><title_en><![CDATA[Quantity and structure of silver fir and Norway spruce biomass in variable climatic conditions]]></title_en><user_id>6061</user_id><user_firstLast_name>Andreja Đuka</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2019-04</proposal_call><code>UIP-2019-04-7766</code><acronim><![CDATA[BiomassInChange]]></acronim><duration>01.03.2021 - 28.02.2026</duration><status>U tijeku</status><financ_value>248.245,48 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Šumarstvo, </scie_field_hr><scie_field_en>Forestry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet šumarstva i drvne tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Forestry and Wood Technology]]></institution_en><team_members_id>6826, 22533, 3748, 864991, 865050, 865055, 4230, 867386, </team_members_id><team_members_names><![CDATA[Ivica Papa, Dinko Vusic, Milivoj Franjevic, Branko Ursić, David Janeš, Ivan Žarković, Kristijan Tomljanović, Mihael Lovrinčević, ]]></team_members_names><keywords_hr><![CDATA[sanitarna sječa, šumska biomasa, otvorenost šuma, gradacije potkoranjaka, elementarne nepogodne]]></keywords_hr><keywords_en><![CDATA[sanitary felling, forest biomass, forest accessibility, bark beetle outbreaks, natural disasters]]></keywords_en><summary_hr><![CDATA[Obična jela (Abies alba Mill.) i obična smreka (Picea abies (L.) Karsten) zajedno čine 11,8 % udjela u ukupnoj drvnoj zalihi Hrvatske te su i najzastupljenije četinjače. Prema podacima iz 2016. 64 % je značajno oštećenih stabala jele gdje je osutost krošnje veća od 25 %. Osutost smrekovih krošanja na nacionalnoj razini iznosi 59,3 %, a u Gorskome kotaru čak 96,2 %. Kao posljedica promjene prirodnih stanišnih čimbenika javlja se propadanje i odumiranje stabala, poremećaj šumskih ekosustava te pad proizvodnosti sastojina. Kod pridobivanja drva u tržišno usmjerenom gospodarstvu važno je razumijevanje razredbe drvnih proizvoda po kakvoći, dok je za utvrđivanje očekivane vrijednosti drvnog obujma pri planiranju šumarskih radnih operacija važno znati količinu i kakvoću drvnih sortimenata koje je moguće proizvesti. Šumska drvna biomasa, obnovljiv je izvor energije pa se i povećavanjem njezina iskorištavanja povećava udio obnovljivih izvora energije u ukupnoj energetskoj bilanci. Štete koje nastaju od posljedica klimatskih ekstrema i nevremena pogoduju razvoju populacije potkornjaka koji kao sekundarni štetnici nalaze povoljne uvjete za svoj razvoj i nagli porast populacije. Gradacije potkornjaka kao pulsno eruptivnih vrsta nastaju obično u razdoblju od jedne do tri godine nakon nevremena. Predloženo istraživanje doprinosi analizi posljedica na šume i gospodarenje šumama u promjenjivim klimatskim uvjetima te omogućuje nove spoznaje i njihovu primjenu u sličnim okolnostima u budućnosti. Intenzivno sušenje stabala jele i smreke velik je problem u smislu održivog gospodarenja te proizvodnje kvalitetnih drvnih sortimenata iz nacionalnih prebornih šuma što dovodi do razlike između planirane i proizvedene sortimentne strukture te između planiranih i ostvarenih prihoda proizvodnje čak i do granice isplativosti šumsko-uzgojnih radova.]]></summary_hr><summary_en><![CDATA[Silver fir (Abies alba Mill.) and Norway spruce (Picea abies L.) together amount to 11.8% of the total growing stock of Croatia and are the most common conifers. According to data from 2016, 64% of silver fir trees are significantly damaged with crown transparency greater than 25%. Crown transparency of Norway spruce on the national level is 59.3%, while in Gorski kotar is 96.2%. As a result of the change in stand conditions, the dieback of trees and disturbances in forest ecosystems stand production and timber quality is declining. When producing timber in a market-driven economy, it is important to understand the quality of timber products especially during the planning of forest management where expected timber value can be determined from assortment tables. Wood biomass is a renewable source of energy, and by increasing its utilization, it increases the share of renewable energy sources in the total energy balance. The damage caused by the effects of climate extremes is leading to the outbreaks of bark beetles which have favourable conditions for their development and a sudden increase in population. Bark beetle outbreaks as pulsating eruptive species usually occur in the period of one to three years after the climatic extremes. Such research is only possible with the creation of new coherent research groups that this project proposal allows. The proposed research contributes to the analysis of the consequences on forests and the management of forests in changing climatic conditions and enables new knowledge and their application in similar circumstances in the future. Fast drying of fir and spruce trees is a significant problem in terms of sustainable management and the production of high-quality timber assortments from selective national forests, which results in differences between planned and produced assortment structures and between expected and realised production revenues even to the level of profitability of forest management operations.]]></summary_en></project><project>
<id>8705</id><title_hr><![CDATA[Socijalno-ekološki izazovi ruralnog razvoja: objektivni i subjektivni pokazatelji otpornosti hrvatskih ruralnih socijalno-ekoloških sustava]]></title_hr><title_en><![CDATA[Social-ecological challenges of rural development: objective and subjective indicators of resilience of Crotian rural social-ecological systems]]></title_en><user_id>5335</user_id><user_firstLast_name>Tijana Trako Poljak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2019-04</proposal_call><code>UIP-2019-04-5257</code><acronim><![CDATA[SECRURAL]]></acronim><duration>01.01.2020 - 31.12.2024</duration><status>Završio</status><financ_value>155.961,64 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Sociologija, Interdisciplinarne društvene znanosti, </scie_field_hr><scie_field_en>Sociology, Interdisciplinary social sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>7578, 5850, 26402, 26673, 855432, 858328, </team_members_id><team_members_names><![CDATA[Jelena Puđak, Jelena  Zlatar Gamberožić, Mateja Jež Rogelj, Krešimir Žažar, Vladimir Ivanović, Bruno Šimac, ]]></team_members_names><keywords_hr><![CDATA[ruralni socijalno-ekološki sustav, indeks ruralne razvijenosti, prilagodljivost, objektivni pokazatelji otpornosti, subjektivni pokazatelji otpornosti]]></keywords_hr><keywords_en><![CDATA[rural socio-ecological system, rural development index, adaptability, objective indicators of resilience, subjective indicators of resilience]]></keywords_en><summary_hr><![CDATA[Glavni je cilj predloženog projekta utvrditi stanje razvijenosti hrvatskih ruralnih područja i kapacitet otpornosti socijalno-ekološkim izazovima na početku 21. st. Pritisci globalizacije, zajedno s realnošću ekološke krize, egzogeni su čimbenici koji nisu zaobišli ni hrvatska sela. Postsocijalističko nasljedovanje, ratna razaranja, tranzicija u demokratski liberalni sustav, te pristup Europskoj uniji, samo su neki od endogenih izazova perspektivama ruralnog razvoja. Međutim, danas kada ruralna područja zauzimaju ključno mjesto u međunarodnim razvojnim strategijama kao čuvari kulturnog i prirodnog bogatstva, u Hrvatskoj izostaju sustavna znanstvena istraživanja koja bi služila kao podsticaj za izradu strategija ruralnog razvoja prilagođenih hrvatskim okolnostima. Takve strategije mogu biti učinkovite i samo ako se ruralna područja i stanovništvo počnu razumijevati kao aktivni sudionici suvremenih kretanja. U istraživanju se stoga oslanjamo na nova znanja i metodologiju koja ruralna područja definiraju kao dinamične socijalno-ekološke sustave (RSES) s kapacitetima prilagodbe i otpornosti. Posebice se oslanjamo na autore koji uz objektivne pokazatelje otpornosti naglašavaju često zanemarenu subjektivnu dimenziju (socijalni, ljudski i kulturni kapital). U istraživanju ćemo koristiti mješovite metode istraživanja: 1) „desk“ metoda, kako bismo utvrdili objektivne pokazatelje otpornosti hrvatskih RSES-ova, 2) metoda ankete, kako bismo istražili subjektivne pokazatelje otpornosti hrvatskih RSES-ova na nacionalno reprezentativnom uzorku, te omogućili usporedbu međusobno i s urbanim sredinama, i 3) 200 intervjua s lokalnim stanovništvom i dionicima u 20 područja svih hrvatskih regija, kojima ćemo dubinskih istražiti subjektivnu dimenziju nošenja sa socijalno-ekološkim izazovima u svakodnevnom životu. Rezultat ovog sustavnog pristupa bit će izrađen i istražen model izračuna indeksa otpornosti hrvatskih ruralnih područja na temelju objektivnih i subjektivnih pokazatelja.]]></summary_hr><summary_en><![CDATA[The main goal of the project is to determine the current state of development of Croatian rural areas and their capacity for resilience against social-ecological challenges. Globalization processes, further aggravated by global ecological crisis, exert exogenous pressures on all parts of the world and Croatian rural areas are no exception. Post-socialist legacy, wartime destruction, transition to democratic liberal system, and accession to the European Union are just some of the endogenous challenges to the perspectives of rural development. However, while rural areas are regaining principal position in international developmental policies, there is a lack of systematic scientific research in Croatia that could inform national rural development strategies, which must be adapted to the local context. Furthermore, such strategies can only be successful if rural areas and their population are seen as active participants. In our research we, therefore, rely on new theoretical and methodological approaches, which define rural areas as dynamic social-ecological systems (RSES) with the capacity for adaptation and resilience. We especially rely on those authors who emphasize not only objective indicators of resilience but also focus on frequently neglected subjective dimension (social, cultural and human capital). In our research we will use mixed methodology: 1) desk research, to determine objective indicators of resilience of Croatian RSESs, 2) survey research, to examine subjective indicators of resilience of Croatian RSESs on a representative national sample, and enable comparison between them and with urban areas, and 3) 200 deep semi-structured interviews with local population and relevant actors across all Croatian regions, for an in-depth analysis of coping mechanisms in everyday lives. The overall result of the project will be a constructed and analyzed model for resilience index measurement for Croatian rural areas comprised of objective and subjective indicators.]]></summary_en></project><project>
<id>8711</id><title_hr><![CDATA[Multicentrične kovalentne veze i pi-interakcije određuju fizička svojstva kristala organskih radikala]]></title_hr><title_en><![CDATA[Multicentric covalent bonding and pi-interactions define physical properties of crystals of organic radicals]]></title_en><user_id>13343</user_id><user_firstLast_name>Krešimir Molčanov</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-4674</code><acronim><![CDATA[MULTICENTRICBONDING]]></acronim><duration>01.02.2020 - 31.01.2024</duration><status>Završio</status><financ_value>130.068,35 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, Fizika, </scie_field_hr><scie_field_en>Chemistry, Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>12831, 21309, 25855, 25778, 25776, 864856, </team_members_id><team_members_names><![CDATA[Marijana Jurić, Valentina Milašinović, Vedran Vuković, Jelsch Christian, Anna Krawczuk, Petra Stanić Stanić, ]]></team_members_names><keywords_hr><![CDATA[multicentrične kovalentne veze, međumolekulske interakcije, kristalografija, gustoća naboja, radikali]]></keywords_hr><keywords_en><![CDATA[multicentric covalent bonding, intermolecular interactions, crystallography, charge density, radicals]]></keywords_en><summary_hr><![CDATA[Glavni cilj projekta je dizajn i priprava kristala na bazi organskih radikala kod kojih se mogu ugađati prijenos naboja i energijski procijep, te njihov razvoj kao funkcionalnih materijala. Posebna pažnja bit će posvećena prirodi pi-interakcijâ između radikala, koje mogu imati djelomičan kovalentni karakter (multicentrične dvoelektronske veze, poznate kao &#39;palačinka-veze&#39;). Prirodu multicentričnih veza istraživat ćemo određivanjem eksperimentalne gustoće naboja iz rendgenske difrakcije te kombinacijom temperaturno ovisne rendgenske difrakcije i rendgenske difrakcije pri visokom tlaku. Istraživanja će se razvijati u dva glavna smjera: 1) priprava novih soli i sustava s prijenosom naboja temeljenih na organskim radikalima (uglavnom semikinonima, ali ćemo koristiti i druge planarne organske radikala) te određivanje njihovih svojstava (kristalna struktura, magnetska i električna svojstva) i 2) detaljno proučavanje multicentričnih kovalentnih veza i sličnih interakcija među organskim radikalima, na izabranim modelnim sustavima (kombinacijom određivanja gustoće naboja iz rendgenske difrakcije, temperaturno-ovisne difrakcije i difrakcije pri visokom tlaku te kvantno-kemijskih računa). Dodatni cilj ovoga projekta je uspostavljanje istraživanja gustoće naboja u Hrvatskoj; također ćemo započeti i s rendgenskom difrakcijom pri visokom tlaku.]]></summary_hr><summary_en><![CDATA[The main goal of the project is to design and prepare crystals of organic radicals suitable for tuning of the charge transfer and band gap, which can be used to design functional materials. Special attention will be given to the nature of pi-interactions between the radicals, which may involve partially covalent multicentric bonding (&#39;pancake bonding&#39;). We will undertake a thorough experimental study of the &#39;pancake bonds&#39; by X-ray charge density coupled by quantum chemical computations; under non-ambient conditions we will use high-pressure and variable-temperature single-crystal X-ray diffraction. Our work will branch into two main directions: 1) synthesis of novel salts and charge transfer compounds of organic radicals (mainly semiquinone radical anions, but similar planar organic radicals will also be used) and study of their properties (crystal structure, magnetic and electrical properties) and 2) in-depth study of multicentric covalent bonding and other interactions between stacked radicals on selected model compounds (a combination of X-ray charge density, non-ambient crystallography and quantum chemical computation). In addition, this project will be aimed towards establishing X-ray charge density research in Croatia, and will also introduce high-pressure X-ray diffraction.]]></summary_en></project><project>
<id>8712</id><title_hr><![CDATA[Razvoj novih rješenja za karakterizaciju i zaštitu brončane kulturne baštine  izložene vanjskom okolišu]]></title_hr><title_en><![CDATA[Development of New Solutions for Characterization and Protection of Bronze Cultural Heritage Exposed to Outdoor Environment]]></title_en><user_id>5203</user_id><user_firstLast_name>Helena Otmačić Ćurković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-5030</code><acronim><![CDATA[BroCH]]></acronim><duration>07.01.2020 - 06.03.2024</duration><status>Završio</status><financ_value>153.892,10 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Kemijsko inženjerstvo, Temeljne tehničke znanosti, Interdisciplinarne tehničke znanosti, </scie_field_hr><scie_field_en>Chemical engineering, Basic engineering sciences, Interdisciplinary technological sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet kemijskog inženjerstva i tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Chemical Engineering and Technology]]></institution_en><team_members_id>6981, 1437, 23682, 25899, 5803, 19699, 19813, 26352, 25949, 20143, 19845, 26030, 855924, 862801, 20245, </team_members_id><team_members_names><![CDATA[Sanja Martinez, Ljerka Kratofil Krehula, Dajana Mikić, Ivana Šoić, Domagoj Šatović, Katarina Marusic, Tadeja  Kosec, Neven Peko, Antonia Matković Šerić, Stela Cvetnić-Radić, Ana Vranić Rob, Saman Hosseinpour, Angela Kapitanović, Ines Šoljić, Marko Viskić, ]]></team_members_names><keywords_hr><![CDATA[kulturna baština, korozija, korozijska zaštita, organske prevlake, elektrokemijske tehnike]]></keywords_hr><keywords_en><![CDATA[cultural heritage, corrosion, corrosion protection, organic coatings, electrochemical techniques]]></keywords_en><summary_hr><![CDATA[Brončane skulpture izložene na javnim površinama su važan dio kulturne baštine, no korozivna gradska atmosfera uzrokuje njihovu degradaciju. Cilj ovog projekta je razviti nova rješenja za njihovu karakterizaciju te unapređivanje postupaka njihove zaštite. U tu svrhu, najprije će se spektroskopskim i elektrokemijskim tehnikama provesti detaljna karakterizacija izabranih urbanih brončanih skulptura na temelju kojih će se definirati uvjeti provedbe laboratorijskih istraživanja. Potom će se istražit mogućnost primjene dugolančanih organskih kiselina za poboljšanje adhezije organskih premaza, na bazi vode kao i na bazi organskih otapala, na brončanu podlogu čime bi se osigurala njena bolja i dugotrajnija korozijska zaštita. Utvrdit će se uvjeti pri kojima dolazi do nastanka čvrsto vezanog zaštitnog sloja organske kiseline u ovisnosti o metodi nanošenja i sastavu podloge te da li interakcija funkcionalnih skupina organske kiseline i premaza može dovesti do poboljšanja adhezije premaza. Zaštitna svojstva modificiranog premaza istražit će se ubrzanim korozijskim ispitivanjima uz primjenu ionizirajućeg zračenja i industrijske komore kao i elektrokemijskim ispitivanjima u elektrolitu koji simulira urbanu kišu.Dodatni inovativni aspekt ovog projekta je razvoj senzorskog dijela uređaja za određivanje korozijske stabilnosti brončanih skulptura. Elektrokemijske metode su temeljne metode za karakterizaciju korozijske stabilnosti materijala, no za njihovu provedbu uglavnom je nužno koristiti elektrokemijsku ćeliju s vodenim elektrolitom što otežava primjenu na realnim objektima zakrivljene geometrije. U projektu će se ispitati mogućnost konstruiranja jednostavne elektrokemijske ćelije s elektrolitom na bazi hidrogela odnosno vodljivom pastom koja bi bila primjenjiva za provođenje nedestruktivnih elektrokemijskih istraživanja brončanim skulpturama. Ćelija će se testirati na laboratorijskim i realnim uzorcima kako bi se utvrdila njena primjenjivost u praksi.]]></summary_hr><summary_en><![CDATA[Bronze sculptures exposed in public areas are an important part of cultural heritage, but corrosive urban atmospheres lead to their degradation. The aim of this project is to develop new solutions for their characterisation and to improve methods for their protection.Firstly, a detailed spectroscopic and electrochemical material characterization of selected bronze sculptures will be conducted in order to define key parameters for laboratory studies.Then the possibility of using long-chain organic acids for improved adhesion of solvent and water-based organic coatings on the bronze substrate will be examined. The conditions under which a strongly bonded organic acid layer is formed on the bronze surface will be determined, as well as whether the interaction between the functional groups of organic acids and coatings can lead to improved adhesion of the coating. The protective properties of the modified coatings will be investigated by accelerated corrosion tests using ionizing irradiation and an industrial chamber, as well as by electrochemical tests in electrolytes that simulate urban rain.An additional innovative aspect of this project is the development of an electrochemical cell for corrosion measurements that could be easily applied to bronze sculptures. Electrochemical methods are essential methods for characterizing the corrosion stability, but require the use an electrochemical cell with aqueous electrolyte, which makes it difficult to apply on real objects of curved geometry. This project will explore the possibility of designing a simple electrochemical cell with hydrogel or conductive paste electrolyte that would be applicable for conduction of non-destructive electrochemical testing on bronze sculptures. The cell will be tested on laboratory samples as well as on sculptures in order determine its practical applicability.]]></summary_en></project><project>
<id>8714</id><title_hr><![CDATA[Crijevne bolesti u djece: pogled izvan probavnog sustava]]></title_hr><title_en><![CDATA[Chronic bowel diseases in children: looking beyond the gut]]></title_en><user_id>2694</user_id><user_firstLast_name>Iva Hojsak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-3028</code><acronim><![CDATA[AUTORUNGUT]]></acronim><duration>01.01.2020 - 31.12.2023</duration><status>Završio</status><financ_value>131.475,21 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Kliničke medicinske znanosti, Javno zdravstvo i zdravstvena zaštita, </scie_field_hr><scie_field_en>Clinical sciences, Public health and health services, </scie_field_en><institution_hr><![CDATA[Klinika za dječje bolesti Zagreb]]></institution_hr><institution_en><![CDATA[Children's Hospital Zagreb]]></institution_en><team_members_id>5694, 4795, 1081, 3050, 4001, 24092, 5757, 24120, 25201, 21390, 865196, </team_members_id><team_members_names><![CDATA[Sanja Kolaček, Zrinjka Mišak, Mario Habek, Magdalena Krbot Skoric, Marko Jelić, Tena  Niseteo, Ana Močić Pavić, Antonella Geljić, Ivana Trivić, Sara Sila, Paola Blagec, ]]></team_members_names><keywords_hr><![CDATA[kronične upalne bolesti crijeva, iritabilni kolon, autonomni živčani sustav, tjelesna aktivnost, djeca]]></keywords_hr><keywords_en><![CDATA[inflammatory bowel disease, irritable bowel syndrome, autonomic nervous system, physical activity, children]]></keywords_en><summary_hr><![CDATA[Iako su kronične upalne bolesti crijeva (IBD) i sindrom iritabilnog kolona (IBS) vrlo različite bolesti, čija se etiopatogeneza, tijek, liječenje i komplikacije uvelike razlikuju, ove bolesti imaju i brojne sličnosti. Uzrokuju bolove u trbuhu, promjene u stolici, smanjuju kvalitetu života bolesnika, a sve ih također odlikuje kronična upala. Usto, u bolesnika s IBD-ijem koji nije aktivan, simptomi su često posljedica funkcijskog poremećaja za čiju patogenezu se odgovornom smatra disfunkcija osovine mikrobiota-crijevo-mozak. Ova osovina ima dvosmjerno djelovanje, crijevne promjene imaju utjecaj na neurološki sustav (osjet boli), ali i neurofiziološki čimbenici mogu djelovati na crijevo putem autononog živčanog sustava (ANS). Iako se navedeno čini zanimljivim u teoriji, malo je istraživanja, posebice u pedijatrijskoj populaciji, koja su pokušala dokazati ulogu osovine mikrobiota-crijevo-mozak u pojavi simptoma. Osim toga, ostaje nepoznato mogu li vanjske promjene kao što je fizička aktivnost djelovati na ovu osovinu. Postoje ograničeni podaci u odraslih ispitanika koji potvđuju da fizička aktivnost, ne samo da poboljšava tjelesnu spremnost već da pozitivno djeluje na mentalno zdravlje, sastav crijevne mikrobiote, tonus ANS-a, bolju kontrolu simptoma i poboljšanje kvalitete života. U djece nema nikakvih relevantnih znanstvenih istraživanja. Ova će studija pokušato procijeniti važnost pojave disfunkcije ANSa te disbioze u djece s IBSom u usporedbi s IBD-jem u remisiji i zdravim kontrolama. Osim toga nastojat će utvrditi može li strukturirana tjelesna aktivnost polučiti promjene u ANSu i crijevnoj mikrobioti čineći ju sličnijima onoj zdrave populacije (zdrave kontrole). Osim toga utvrdit će se poboljšava li ona kvalitetu života i sastav tijela u djece s IBD-jem u remisiji i IBS-om. ]]></summary_hr><summary_en><![CDATA[Although inflammatory bowel disease (IBD) and irritable bowel syndromes (IBS) are very different diseases, whose etiopathogenesis, course, treatment and complications significantly differ, these diseases also have similarities; cause abdominal pain with changes in frequency and consistency of the stool, significantly affect the patients quality of life (QoL), and in both diseases there are signs of mild active intestinal inflammation. In addition, in IBD patients, in the absence of disease activity, symptoms are largely attributable as functional for which pathogenesis the microbiota-gut-brain axis is recognized as crucial. This axis has a two-way effect, the changes in the intestine have neurological repercussions (sensory of pain) but also neuropsychological factors may have an effect on the digestive system through the autonomic nervous system (ANS).  Although interesting in theory, minimal has been done in the terms of research in pediatric population to clarify this hypothesis of microbiota-gut-brain axis involvement in the symptoms.  Strategy which remains unclear is whether outside stimuli like physical activity could induce change in the microbiota-gut-brain axis. There are some data in adults showing that physical activity is associated with improvements, not only in physical fitness, but also in mental health, microbiome composition, ANS tone, better symptoms control and QoL improvement. There are no data for pediatric population. This study will try to evaluate whether there is a significant pattern of intestinal microbiota and ANS disfunction in children with IBS and IBD in remission and whether inclusion in structured physical activity can change their microbiota composition and ANS function more towards healthy controls. It would be of interest to see whether physical activity further improves QoL and body composition in both groups of patients.]]></summary_en></project><project>
<id>8715</id><title_hr><![CDATA[Rasvjetljavanje evolucije satelitnih DNA visokoprotočnim analizama satelitoma srodnih vrsta]]></title_hr><title_en><![CDATA[Satellite DNA evolution illuminated by high-throughput satellitome analyses of related species]]></title_en><user_id>332</user_id><user_firstLast_name>Brankica Mravinac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-5522</code><acronim><![CDATA[EvoSat]]></acronim><duration>15.03.2020 - 14.08.2024</duration><status>Završio</status><financ_value>132.603,36 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>506, 2778, 2776, 22650, 26098, 26112, 858410, </team_members_id><team_members_names><![CDATA[Miroslav Plohl, Eva Šatović, Tanja Vojvoda Zeljko, Monika Tunjić, Juan J Pasantes, Daniel  García Souto, Damira Veseljak, ]]></team_members_names><keywords_hr><![CDATA[satelitom, satelitna DNA, Tribolium, kamenice, evolucija ponovljenih DNA]]></keywords_hr><keywords_en><![CDATA[satellitome, satellite DNA, Tribolium, oysters, repetitive DNA evolution]]></keywords_en><summary_hr><![CDATA[Uzastopno ponovljene sekvence DNA, poznate kao satelitne DNA (satDNA), najčešće smještene u heterokromatinskim regijama, čine značajne dijelove eukariotskih genoma. Desetljećima je biološka važnost satDNA bila osporavana prvenstveno zbog njihove nekodirajuće prirode, ali u novije vrijeme otkriva se značajna uloga satDNA u strukturi centromera, remodeliranju kromatina, specijacijskim procesima, kao i u tumorogenezi. Zbog uzastopne ponovljenosti ove sekvence DNA mahom su izostavljene u genomskim projektima. U posljednjih nekoliko godina, visokoprotočno sekvenciranje i pripadajući specijalizirani računalni alati stubokom mijenjaju studije satDNA, omogućavajući otkrivanje ukupnog sadržaja satDNA u genomu, nazvanog satelitom. Glavni cilj našeg projekta je istražiti satelitome dviju skupina beskralješnjaka: (i) kukaca roda Tribolium, čije genome karakteriziraju iznimno bogate satDNA smještene u velikim heterokromatinskim domenama te (ii) školjkaša, za koje je poznato da imaju nizak udio satDNA te kromosome bez velikih heterokromatinskih blokova. U svrhu istraživanja satelitoma osam vrsta, kombinirajući Illumina i PacBio sekvenciranje s različitim eksperimentalnim metodama, proučit ćemo: (i) vrsno-specifične i grupno-specifične satDNA, (ii) dinamiku i kromosomsku distribuciju satDNA sekvenci, (iii) organizacijske obrasce satDNA sljedova, (iv) postojanje i očuvanost potencijalno funkcionalnih motiva u sekvencama satDNA, (v) sličnosti i povezanost satDNA s mobilnim elementima. Očekujemo da ćemo sveobuhvatnim istraživanjem satelitoma dviju različitih skupina beskralješnjaka i usporednom analizom dobivenih podataka unaprijediti trenutne spoznaje o strukturi i evoluciji satDNA, uključujući životni ciklus, porijeklo i sudbinu, kao i moguće mehanizme nastanka i širenja uzastopnih ponavljanja te razjasniti veze između satDNA i mobilnih elemenata.]]></summary_hr><summary_en><![CDATA[Tandemly repeated DNA sequences, known as satellite DNAs (satDNAs), constitute significant portions of eukaryotic genomes, being usually located in genetically silent heterochromatin. SatDNA biological relevance has been disregarded for decades mostly due to their non-coding character but it is coming to light that these sequences play important roles in centromere structure, chromatin remodelling, speciation processes, as well as in tumorigenesis. Repetitiveness of satDNAs, that impedes contiguous sequence assemblies, has kept them underrepresented in genome project outputs. Recently, however, high-throughput sequencing accompanied by specialized computational tools has revolutionized satDNA studies enabling discovery of a whole set of satDNAs in a genome, named a satellitome. The main goal of this project is to investigate the satellitomes in two groups of invertebrates: (i) beetles of the genus Tribolium, characterized by highly abundant satDNAs located in large heterochromatic chromosomal domains, and (ii) bivalve species, known to have low satDNA contribution and chromosomes mostly devoid of large heterochromatic blocks. By engaging Illumina and PacBio sequencing combined with experimental methods to study satellitomes of eight species, our work will address: (i) shared and species-specific satDNAs, (ii) satDNA sequence dynamics and chromosomal distribution in the analysed satellitomes, (iii) sequential patterns of satellite repeats, (iv) existence and conservation of potentially functional motifs in satDNA sequences, and (v) satDNA similarities and association with transposable elements (TEs). By comprehensive surveys of satDNA concepts in two different invertebrate groups and ensuing data interlacing, we expect to further current ideas about satDNA structure and evolution, including the life-cycle, origin and destiny of satellite repeats, links between satDNAs and TEs, as well as possible mechanisms involved in the formation and spread of tandem repeats. ]]></summary_en></project><project>
<id>8720</id><title_hr><![CDATA[Visoko razlučiva spektrometrija x-zraka fokusiranim ionskim snopovima]]></title_hr><title_en><![CDATA[High resolution x-ray spectrometry with focused ion beams]]></title_en><user_id>4589</user_id><user_firstLast_name>Stjepko Fazinić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-9429</code><acronim><![CDATA[Hi-REXS]]></acronim><duration>01.01.2020 - 31.05.2024</duration><status>Završio</status><financ_value>132.327,29 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, Interdisciplinarne prirodne znanosti, </scie_field_hr><scie_field_en>Physics, Interdisciplinary natural sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>4976, 4893, 3498, 5072, 5947, 26162, 23721, 26721, 855354, 855359, 864847, 27507, </team_members_id><team_members_names><![CDATA[Iva Božičević Mihalić, Tonči Tadić, Marko Karlušić, Matea Krmpotić, Donny Domagoj Cosic, Domagoj Mudronja, Vladan Desnica, John Campbell, Toni Dunatov, Mauricio Rodriguez Ramos, Anja Mioković, Marija Tkalčević, ]]></team_members_names><keywords_hr><![CDATA[analiza ionskim snopovima, ionska mikroproba, visoko-rezolucijski spektri x-zraka, strukturni i kemijski efekti na x-zrake, višestruke ionizacije]]></keywords_hr><keywords_en><![CDATA[ion beam analysis, ion microprobe, high-resolution x-ray spectra, structural and chemical effects on x-rays, multiple ionizations]]></keywords_en><summary_hr><![CDATA[Tehnike ionskih snopova s akceleratorima koriste se za analize materijala ionskim snopovima (IBA) ili kao alat za brzu i efikasnu modifikaciju materijala ili kreiranje radijacijskih oštećenja u čvrsim tijelima. Povjerenje u analitičke tehnike poput IBA, osobito onih koje se baziraju na znanju fundamentalnih parametara interakcija, ovisi o razumijevanju fizikalnih procesa koje se kriju u temeljima tehnike, te u definiranim analitičkim protokolima. Ovdje predlažemo istraživanja fizikalnih procesa od važnosti za metode spektroskopije x-zraka (XES). Istraživati ćemo utjecaj strukturnih i kemijskih efekata na spektare x-zraka visoke rezolucije nakon pobude ionskim snopovima, uključujući istraživanje efekata na K x-zrakama za elemente od Mg do Fe, emisiju satelitskih x-zraka karakterističnih za višestruke ionizacije težim ionima, te efekte na L i M linijama x-zraka težih elemenata. Značajno ćemo unaprijediti IBA mogućnosti na ionskoj mikroprobi IRBa izgradnjom naprednog WDXRS spektrometra te ćemo demonstrirati njegovu upotrebljiivost i važnost određenih fundamentalnih parametara u istraživanjima objekata kulturnog nasljeđa te u istraživanju materijala, uključujući studije in-situ strukturnih i kemijskih promjena materijala uslijed iradijacije ionskim snopovima. Većina eksperimenata bit će obavljena koristeći ionsku mikroprobu Instituta Ruđer Bošković (IRB). Osim toga, koristit ćemo druge linije na akceleratorima IRBa te obaviti četiri terenska eksperimenta na sinhrotronima i drugim akceleratorima koji imaju spektrometre x-zraka visoke rezolucije da bi dobili komplementarne rezultate. Na kraju projekta novorazvijeni spektrometar bio bi na raspolaganju istraživačima za istraživanja raznih fenomena te za interdisciplinarne primjene. Također, naši mlađi istraživači steći će veliko iskustvo i znanje koje će biti vrlo relevantno za razvoj njihovih budućih karijera. Osim znanstvenih radova očekuju se i konkretni rezultati istraživanja objekata kulturnog nasljeđa.]]></summary_hr><summary_en><![CDATA[Accelerator-based ion beam techniques play prominent roles either in ion beam analysis (IBA) or as tools for fast and efficient modification of materials or creation of radiation damage in solids. Confidence in analytical techniques like IBA, in particular those that rely on knowledge of fundamental interaction parameters, is based on understanding of physical processes that lay behind the particular technique and in defined analytical protocols. We propose to study physical processes of importance for x-ray emission spectroscopy (XES) techniques. We will study structural and chemicall effects on high resolution x-ray spectra emitted after excitation by ion beams, including studies of solid state and chemical effects to K x-rays for elements from Mg to Fe, emission of multiple ionization x-ray satellites by heavy ions, and effects to L and M x-rays of heavier elements. We will significantly increase capabilities for IBA at the RBI ion microbeam station by building new advanced high resolution WD x-ray spectrometer (WDXRS) and proof its usefulness and importance of fundamental data in the fields of preservation/analysis of cultural heritage objects and in materials science, including  studies of in-situ structural and chemical changes of material under ion beam irradiation. Most of the experimental work will be performed using ion microprobe available at the RBI Tandem Accelerator Facility. In addition, we will use the other facility beamlines to complement the research outcome and we will perform four field experiments at synchrotrons and high resolution XRS facilities abroad. At the project end, newly developed WDXRS system will be on disposal to researchers to study various phenomena and interdisciplinary applications. Our younger researchers will obtain valuable experience and knowledge that will be very relevant for their future cariers. Besides research papers, some relevant results related to preservation of cultural heritage are expected.]]></summary_en></project><project>
<id>8723</id><title_hr><![CDATA[Anžuvinski archiregnum u srednjoistočnoj i jugoistočnoj Europi u 14. stoljeću: pogled s periferije]]></title_hr><title_en><![CDATA[Angevin Archiregnum in East Central and Southeastern Europe in the 14th Century: View from the Periphery]]></title_en><user_id>26237</user_id><user_firstLast_name>Valentina Šoštarić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-9315</code><acronim><![CDATA[AAPSP]]></acronim><duration>01.01.2020 - 31.05.2024</duration><status>Završio</status><financ_value>73.037,36 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Povijest, Etnologija i antropologija, </scie_field_hr><scie_field_en>History, Ethnology and anthropology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zadru]]></institution_hr><institution_en><![CDATA[University of Zadar]]></institution_en><team_members_id>25792, 249, 25841, 26237, 2688, 26394, 534, 5122, 26696, 1430, </team_members_id><team_members_names><![CDATA[Cosmin Popa-Gorjanu, Tomislav Popić, Neven Isailović, Valentina  Šoštarić, Ivan Majnarić, Štefan Štivičić, Dušan  Mlacović, Antun Nekić, Petra Vručina, Mladen Ančić, ]]></team_members_names><keywords_hr><![CDATA[Anžuvinci, Archiregnum, Srednjoistočna Europa, Jugoistočna Europa, periferija, političko središte, 14. stoljeće]]></keywords_hr><keywords_en><![CDATA[Angevins, Archiregnum, East Central Europe, Southeastern Europe, periphery, political center, 14th century]]></keywords_en><summary_hr><![CDATA[Projekt je usmjeren k istraživanju funkcioniranja političke tvorbe na čelu koje je od početka 14. stoljeća do njegovih 80-ih godina stajala anžuvinska dinastija te se temelji na postavci prema kojoj tu političku tvorbu, odnosno način na koji ona funkcionira tijekom 14. stoljeća, treba istraživati kao „Nadkraljevstvo“ (Archiregnum Hungaricum). U središte se istraživačke pozornosti pritom stavljaju pojmovi „(političko) središte“ i „periferija“, a cilj je razaznati narav veza koje ih povezuju te način na koji u tome sudjeluju poglavito akteri s „periferije“. Kako bi se to postiglo izlazi se izvan parametara postavljenih suvremenim nacionalnim granicama i pripadajućim historiografijama, što se projektom postiže usvajanjem suvremenih teorijskih modela te uključivanjem suradnika iz različitih historiografskih tradicija. Ciljevi projekta su pak: istražiti strukture vlasti istočnojadranskih gradova i analizirati njihove poveznice s kraljevskom vlašću; istražiti utjecaj elita na prostoru jugoistočnog oboda anžuvinskog archiregnuma u njegovoj političkoj (dez)integraciji; razumjeti reperkusije interakcije između (elita) pojedinih političkih cjelina koje čine periferiju anžuvinskog archiregnuma u oblikovanju njihovog pojedinačnog odnosa sa središtem; istražiti načine na koje se političko središte nastoji postaviti kao središte iz kojeg se širi dominantni sustav simbola, vrijednosti i vjerovanja; sagledati moć lokalnih aktera/institucija kroz prizmu teritorijalne organizacije i ekstrakcije materijalnih resursa. Ostvarenje tih ciljeva rezultirat će razumijevanjem funkcioniranja anžuvinskog archiregnum-a, promatrajući ga iz perspektive njegove jugoistočne periferije, širokog prostora od Jadranskog mora do Karpata, te će se razviti istraživački okvir i specifična znanja potrebna za komparaciju sa drugim sličnim europskim političkim konfiguracijama.]]></summary_hr><summary_en><![CDATA[The focus of the project is research on the functioning of the political entity governed by the Angevin dynasty from the beginning of the 14th century until the 1380’s. It starts from the assumption that this political entity and manner in which it functioned during the 14th century should be approached as “Arch-Kingdom” (Archiregnum Hungaricum). The research primarily focuses on the terms “(political) center” and “periphery”, and the aim is to understand the nature of connection between the two and the role of the actors from the “periphery” in this process. In order to analyze these processes it was necessary to step out of the boundaries set by contemporary national borders and corresponding historiographies, which is achieved by adopting contemporary theoretical models and through the involvement of researchers from various historiographical traditions. The aims of the project are: to research the structure of the government of the East-Adriatic cities and to analyze their connections with the royal government; research the role of the elites from the southeastern rim of the Angevin Achiregnum in its political (dis)integration; to understand the repercussions of the interaction between the (elites of) individual political entities that formed the periphery of the Angevin Archiregnum on the formation of their individual relationships with the center; to analyze the manner in which the political center strives to become the center that radiates the dominant system of symbols, values and beliefs; to look at the power of local actors/institutions through the prism of territorial organization and extraction of material resources. The completion of these aims will result in the understanding of functioning of the Angevin Archiregnum from the perspective of its southeastern periphery, vast area from the Adriatic Sea to the Carpathians, and in the development of a research frame and specific knowledge necessary for comparison with similar European political formations.]]></summary_en></project><project>
<id>8724</id><title_hr><![CDATA[Dinaridski predgorski bazen između dva eocenska terminalna optimuma: mogući scenarij za sjevernojadranski bazen]]></title_hr><title_en><![CDATA[Dinaridic foreland basin between two Eocene thermal optima: a possible scenario for the Northern Adriatic]]></title_en><user_id>5918</user_id><user_firstLast_name>Vlasta Ćosović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-5775</code><acronim><![CDATA[BREEMECO]]></acronim><duration>02.01.2020 - 01.05.2024</duration><status>Završio</status><financ_value>82.194,57 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Geologija, </scie_field_hr><scie_field_en>Geology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>1058, 5460, 2613, 26691, 4277, 4014, 6023, 4688, 26841, 26713, 23725, 26726, 6680, 865213, </team_members_id><team_members_names><![CDATA[Nenad Tomašić, Dunja Aljinović, Damir Bucković, Dražen Kurtanjek, Ines Galović, Marija Horvat, Igor Felja, Katarina Caput Mihalić, Valeria Luciani, Johannes Pignatti, Stjepan Coric, Antonino Briguglio, Đurđica  Pezelj, Igor Pejnović, ]]></team_members_names><keywords_hr><![CDATA[Eocen, predgorski bazen, Dinaridi, karbonatne stijene, klastiti, termalni optimumi]]></keywords_hr><keywords_en><![CDATA[Eocene, Foreland basin, Dinarides, Carbonates, Clastics, Thermal optima]]></keywords_en><summary_hr><![CDATA[Glavni cilj projekta BREEMECO je istražiti i kvantificirati promjene u zajednicama organizama u plitkomorskim i pelagičkim okolišima izazvane eocenskim termalnim odstupanjima (ranim - i srednje-eocenskim klimatskim optimumima) u području Vanjskih Dinarida. Cilj će se postići: i) istraživanjem promjena sastava zajednice bentosa ciljanih uzoraka Foraminiferskih vapnenanaca (teksturne i strukturne osobine čega su ključne za eliminaciju lokalnih taložnih utjecaja), ii) istraživanjem mineraloških, geokemijskih, sedimentoloških te mikro- i nano-paleonotoloških osobina pelagičkih sedimenta nastalih tijekom navedenih razdoblja, te iii) procjenom (kvantitativnom i kvalitativnom) veličine i karaktera promjena na pojedinim skupinama organizama. Unazad 20-tak godina iz svjetskih su primjera poznate posljedice izazvane jednom odnosno drugom termalnom promjenom na morske strujne režime i na sastav zajednica bentosa u dubokomorskim okolišima, ali do sada nisu opisane promjene koje su se dogodile u transektu plitkomorski – pelagički okoliš. Prostor Dinaridskog predgorskog bazena je jedinstven jer nalazimo plitkomorske i dubokomorske naslage istaložene u rasponu od 50 do 40 milijuna godina i u okviru ovoga projekta utvrditi će se i korelirati promjene izazvane termalnim događanja u naslagama. Dobiveni trendovi promjena mogu se koristiti pri procjeni rizika mogućih recentnih promjena koje se već događaju u sjevernom dijelu Jadranskog mora (promjene uočene na zajednicama dna povezane s hipoksijom u posljednjih 500 godina). Značajni napor će se posvetiti preciznom biostratigrafskom zoniranju eocenskih naslaga (dileme o starosti fliških naslaga), intenzitetu trošenja tek formiranih Dinarida ali i drugih mladih struktura u okruženju, čijim se materijalom punio predgorski bazen. BREEMECO projekt će imati i snažnu međunarodnu komponentu koja uključuje istraživače i odgovarajuće institucije, što će rezultirati povećanjem učinkovitosti i umreženosti hrvatske geološke zajednice.]]></summary_hr><summary_en><![CDATA[The main objective of the BREEMECO project is to investigate and quantify changes in benthic communities from the shallow-water and pelagic environments during the Eocene climatic episodes (Early and Middle Eocene Optima) in the External Dinarides. The aims are the following: i) to detect and interpret the changes in composition of bethos in the Foraminiferal limestones from selected localities, their textural and structural characteristics in particular; ii) to study mineralogical, geochemical, sedimentological, micro- and nano-paleonotological properties of pelagic sediments deposited during these thermal episodes, and iii) to evaluate (quantitatively and qualitatively) magnitude and character of changes in both benthic communities. Since the 2000s, the consequences of one or the other thermal changes have been studied only in deepwater sediments, or only from one or another episode, but so far no studies have been made in the transect shelf-basin. The Dinaridic Foreland basin is one of a few locations in the world where these transition and changes can be studied because deposits covering 50 to 40 Ma occur. This project will correlate the changes from both episodes and from the shallow to pelagic part of the basin. The obtained trends can be used to estimate the risk of changes occurring in the Northern Adriatic (changes observed in benthos in the last 500 ys due to hypoxia). The project will make a significant effort to devise a precise biostratigraphic zonation (related to the controversies about the age of flysch), the intensity of weathering of &#39;&#39;just up-lifted&#39;&#39; Dinarides and other young structures in the vicinity. The BREEMECO project will also have a strong international component involving researchers and relevant institutions, thus will result in increased efficiency and networking of the Croatian geological community.]]></summary_en></project><project>
<id>8726</id><title_hr><![CDATA[Pouzdani i sigurni kompleksni softverski sustavi: Od empirijskih principa prema teoretskim modelima iz perspektive industrijske primjene]]></title_hr><title_en><![CDATA[Reliable and Safe Complex Software Systems: From Empirical Principles to Theoretical Models in View of Industrial Applications]]></title_en><user_id>1409</user_id><user_firstLast_name>Tihana Galinac Grbac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-4216</code><acronim><![CDATA[RELYSOFT]]></acronim><duration>15.02.2020 - 14.02.2024</duration><status>Završio</status><financ_value>108.301,81 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište Jurja Dobrile u Puli]]></institution_hr><institution_en><![CDATA[Juraj Dobrila University of Pula]]></institution_en><team_members_id>5217, 23004, 5358, 890, 6832, 21406, 2658, 20529, 13494, 23101, 865441, 865442, </team_members_id><team_members_names><![CDATA[Per Runeson, Valeria Cardellini , Darko Huljenić, Neven Grbac, Valter Boljunčić, Joao Costa, Goran Mauša, Nikola Tanković, Jean Petric, Sanja Grbac Babić, Mladen Sverko Šverko, Dalibor Fonović, ]]></team_members_names><keywords_hr><![CDATA[software, complex, engineering, reliability, safety]]></keywords_hr><keywords_en><![CDATA[softver, kompleksni, inženjerstvo, pouzdanost, sigurnost]]></keywords_en><summary_hr><![CDATA[Softver progresivno ulazi u svaki aspekt ljudskog života. Broj uređaja i platformi koje okružuju i podupiru ljude u njihovim svakodnevnim aktivnostima kontinuirano raste. Ti uređaji i platforme temelje se na softveru i međusobno su povezani preko Interneta u novoj 5G mreži koja je virtualna, softverski definirana i rekonfigurabilna. Nadalje, kontinuirano raste broj softverskih usluga, raznih softverskih primjena, velikih podataka koji zahtijevaju softversku obradu. S druge strane, globalno tržište softvera je vrlo konkurentno i dinamično, što uvodi izazove tvrtkama za razvoj softvera. U takvim uvjetima, postojeće znanje o inženjerstvu softvera i sustava nije dostatno za postizanje zahtjeva pouzdanosti i sigurnosti sustava. Potrebne su nove teorije i nova znanja. U ovom projektu integriramo istraživanje softverskog i sistemskog inženjerstva s telekomunikacijskom i automobilskom industrijskom pozadinom te uz pomoć matematičkih znanja planiramo dobiti nova znanja potrebna za inženjerstvo pouzdanosti i sigurnost softverskih sustava na globalnom konkurentnom tržištu. U ovom projektu usmjerit ćemo naše napore u sljedeće tri grane istraživanja:1. Ponašanje pogrešaka u softverskim sustavima u evoluciji (modeliranje pouzdanosti, distribucija grešaka i predviđanje kvarova)2. Pouzdanost i sigurnost u dinamičkim okruženjima (Cloud, softverski definirane mreže i globalno tržište)3. Organizacijski aspekti za razvoj softvera]]></summary_hr><summary_en><![CDATA[Software is progressively entering every aspect of human life. The number of devices and platforms surrounding and supporting humans in every day activities is continuously growing. These devices and platforms are software based and interconnected over Internet in the new 5G network, which is virtual, software defined and reconfigurable. Furthermore, there is a continuous growth of the number of software services, variety of software applications, and big data that need software processing. On the other hand, the global software market is highly competitive and dynamic, which introduces challenges for software development companies. In such conditions, current software and system engineering knowledge is inadequate to cope with requirements on reliability and safety system properties. New theories and knowledge are needed. In this project we integrate the software and system engineering research with telecommunication and automotive industry background, and with the aid of mathematical knowledge, to yield new knowledge needed for engineering software system reliability and safety in global competitive market. In this project we will focus our efforts in the following three branches of research:1.	Fault behavior in evolving software systems (Reliability modeling, fault distribution and fault prediction)2.	Reliability and safety in dynamic environments (Cloud, software defined networks and global market)3.	Software development organization aspects ]]></summary_en></project><project>
<id>8730</id><title_hr><![CDATA[Osjetljivost komercijalno važnih školjkaša u akvakulturi istočnog dijela Jadrana na promjene okolišnih uvjeta ]]></title_hr><title_en><![CDATA[Sensitivity of commercially important bivalves from eastern Adriatic aquaculture to variations in environmental conditions]]></title_en><user_id>119</user_id><user_firstLast_name>Lorena Perić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-1956</code><acronim><![CDATA[BEST ADRIA]]></acronim><duration>01.01.2020 - 31.05.2024</duration><status>Završio</status><financ_value>132.628,31 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Biotehnologija, Interdisciplinarne biotehničke znanosti, </scie_field_hr><scie_field_en>Biotechnology, Interdisciplinary biotechnical sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>5800, 6257, 21141, 12700, 123, 4923, 4931, 3996, 1068, 26056, 528, 22579, 25977, 865103, 866587, </team_members_id><team_members_names><![CDATA[Damir Kapetanović, Irena Vardić Smrzlić, Anamarija Kolda, Marino Korlević, Vedrana Nerlović, Valter Kožul, Jakša Bolotin, Svjetlana Bobanović-Ćolić, Željko Linšak, Sanda Antunović, Petra Burić, Paula Žurga, Sandra Marinac-Pupavac, Karla Orlić, Marsej Markovski, ]]></team_members_names><keywords_hr><![CDATA[akvakultura, školjkaši, stres, bakterije, istočni Jadran]]></keywords_hr><keywords_en><![CDATA[aquaculture, bivalves, stress, bacteria, eastern Adriatic]]></keywords_en><summary_hr><![CDATA[Komercijalna akvakultura mediteranske dagnje Mytilus galloprovincialis i europske plosnate kamenice Ostrea edulis prevladava na području istočnog Jadrana. Budući da se proizvodnja školjkaša tradicionalno odvija u in situ uvjetima, njihove odlike u potpunosti ovise o okolišnim uvjetima. Zbog navedenog razloga, uspješnost uzgoja školjkaša zahtijeva obuhvatnije znanje o čimbenicima koji mogu nepovoljno utjecati na kvalitetu krajnjeg proizvoda. Tipična obilježja obalnih područja Jadrana pogodnih za akvakulturu školjkaša su prostorna i vremenska heterogenost hidroloških uvjeta i razine hranjivih tvari, a u današnje vrijeme i sve veći rizik uvjetovan izlaganjem kemijskim zagađivalima dospjelih s kopna. Svi navedeni čimbenici, pojedinačno ili u sprezi, mogu potaknuti fiziološki stres školjkaša u uzgoju. Osim toga, zbog iznimno velike sposobnosti filtriranja školjkaši u velikoj mjeri nakupljaju mikroorganizme koji se nalaze u vodenom stupcu. Zbog učestale pojavnosti i abundancije u obalnim vodama, bakterije roda Vibrio izazivaju veliku pozornost. Epidemije uzrokovane izlaganjem patogenim vrstama vibrija u morskoj vodi i konzumacijom kontaminiranih školjkaša ili blago termički obrađenih od globalnog je javno zdravstvenog značaja. No, povezanost lokalnog okoliša sa mikrobnom zajednicom školjkaša u uzgoju istočne obale Jadrana je neostatno dokumentirana. Cilj predstavljenog istraživanja, temeljenog na in situ eksperimentu, je utvrditi kako lokalne promjene okolišnih uvjeta utječu na odlike školjkaša u uzgoju i posljedično na strukturu njihove mikrobne zajednice i podložnost kolonizaciji patogenih vrsta vibrija. Navedeni aspekt će biti od ključne važnosti za produktivnost i održivost akvakulture školjkaša u Jadranu, a naročito u svjetlu nepovoljnog učinka globalnih klimatskih promjena u sprezi sa sve intenzivnijim antropogenim pritiscima predviđenim u bliskoj budućnosti. ]]></summary_hr><summary_en><![CDATA[Commercial aquaculture of Mediterranean mussel Mytilus galloprovincialis and European flat oyster Ostrea edulis largely predominates in the eastern Adriatic. Since bivalve production is traditionally carried out in situ their performance is entirely dependent on environmental conditions. Therefore, the overall success of aquaculture practice requires improved understanding of factors that may negatively influence the quality and health of bivalve products. Adriatic coastal environments suitable for bivalve aquaculture typically display spatial and temporal heterogeneity of hydrological conditions and nutrients availability, and are nowadays increasingly threatened by exposure to chemical pollutants originating from adjacent land. All these factors may, alone or in combination, elicit physiological stress in farmed bivalves. Further, because of their extraordinary seawater filtering capacity, bivalves readily acquire microbes from water column. Among them, bacteria of the genus Vibrio have attracted particular interest given their abundance and ubiquity in coastal waters. In particular, diseases caused by exposure to pathogenic Vibrio species in water and consumption of contaminated raw or undercooked seafood have raised global public health concerns. In addition, interaction of local environment with microbial community associated to bivalves farmed in the eastern Adriatic aquaculture is apparently poorly documented. The aim of this field based project is to investigate how locally modulated environmental conditions affect the performance of farmed bivalves and consequently their microbial community composition and susceptibility to colonization by Vibrio pathogens. This aspect is of paramount importance for productivity and sustainability of bivalve aquaculture along the Adriatic, in particular in light of the negative impacts of global climate change in combination with more intense anthropogenic pressure foreseen in the near future.]]></summary_en></project><project>
<id>8735</id><title_hr><![CDATA[Topološka raznolikost oksalatnih spojeva: sinteza, svojstva i upotreba za okside]]></title_hr><title_en><![CDATA[Topological Versatility of Oxalate-Based Compounds: Synthesis, Properties and Oxide-Related Usage]]></title_en><user_id>12831</user_id><user_firstLast_name>Marijana Jurić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-5742</code><acronim><![CDATA[TOPOXAL-SYPROXID]]></acronim><duration>15.01.2020 - 14.01.2024</duration><status>Završio</status><financ_value>126.962,64 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, Fizika, </scie_field_hr><scie_field_en>Chemistry, Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>3297, 21308, 2787, 22816, 13343, 858406, </team_members_id><team_members_names><![CDATA[Ana Šantić, Lidija Kanižaj, Damir Pajić, Pavla Šenjug, Krešimir Molčanov, Ana Lozančić, ]]></team_members_names><keywords_hr><![CDATA[Homo- i heterometalni koordinacijski spojevi, oksalatni most, strukturna analiza, mješoviti metalni oksidi, magnetska i električna svojstva]]></keywords_hr><keywords_en><![CDATA[Homo- and heterometallic coordination compounds, oxalate bridge, structural analysis, mixed-metal oxides, magnetic and electrical properties]]></keywords_en><summary_hr><![CDATA[Metal-organski koordinacijski spojevi zbog prilagodljive prirode organskih liganda i njihovog različitog načina koordiniranja, kao i geometrije metalnih iona koji ih izgrađuju, mogu imati različite topologije i arhitekture. Osim strukturnog svojstva, ove kristalne krutine mogu pokazivati i druga zanimljiva svojstva koja proizlaze iz različitih funkcionalnosti koja se uvode u ove materijale, naročito elektronska svojstva tj. magnetska, električna ili optička, prihvatljivim odabirom metalnih iona, organskih spojnica i načina na koji su oni međusobno povezani u krutini, ili uvođenjem funkcionalnih molekula u pore. U potrazi za novim molekulskim magnetima intenzivno se proučavaju kompleksi koji sadrže oksalatnu skupinu, C2O42–, koja ima mogućnosti raznolikog vezivanja na metalne ione i posredovanja u magnetskoj interakciji između paramagnetskih centara. Također, zbog razlaganja ovog liganda na plinovite faze, CO2 i CO, pri niskim temperaturama, kao i njegove niske cijene, heterometalni oksalatni sustavi se koriste kao molekulski prekursori za pripravu mješovitih metalnih oksida termičkom pretvorbom. Sveukupni znanstveni cilj predloženog projekta, koji se temelji na interdisciplinarnom pristupu, je istražiti nove homo- i heterometalne komplekse s premošćujućom oksalatnom skupinom, te okside priređene iz odgovarajućih oksalatnih spojeva. Pripremljenim oksalatnim spojevima i) homopolinuklearnim s jednostavnim aminima i ii) heteropolinuklearnim, sintetiziranim pristupom građevnih blokova, koji sadrže aromatske N-donorske ligande ili jednostavne amine, istražit će se strukturna, termička, magnetska i električna svojstva. Za svaki jednofazni produkt dobiven termičkom razgradnjom i) novopripravljenih heterometalnih oksalatnih spojeva, ii) smjese pogodnih, već poznatih hetero- i/ili homometalnih oksalatnih spojeva, te iii) čvrstih otopina dvaju prikladnih oksida, odredit će se energetski procijepi i fotokatalitička aktivnost, te istražiti magnetska i električna svojstva.]]></summary_hr><summary_en><![CDATA[The flexible nature of organic ligands and their variety of coordination modes, together with the geometry of the constitutive metal ions, provide a diversity of topologies and architectures of metal-organic coordination compounds. In addition to the structural property these crystalline solids may exhibit other interesting properties resulting from different functionalities introduced into these materials, in particular, electronic properties, i.e. magnetic, electrical or optical, by acceptable selection of the functional nodes, organic linkers and the way in which they are connected in the solid, or by including functional molecules in the pores. In the search for new molecule magnets, oxalate-based complexes have been intensively studied; the oxalate moiety, C2O42–, has rich binding facilities and can act as efficient mediators of the magnetic interaction between paramagnetic centres. Also, due to its easily decomposes to gaseous CO2 and CO at low temperatures and cheapness, heterometallic oxalate compounds have been used as molecular precursors for the preparation of mixed-metal oxides by thermal conversion. The overall scientific aim of this project, based on interdisciplinary approach, is to explore novel homo- and heterometallic oxalate-bridged complexes and the oxides derived from suitable oxalate species. Prepared oxalate compounds i) homopolynuclear with simple amine and ii) heteropolynuclear, synthesized by a building block approach, containing organic N-donor ligand or simple amine, will be structural, thermal, magnetic and electrical characterized. For every single-phase product obtained by thermal decomposition of i) newly synthesized heterometallic oxalate compounds, ii) the mixture of agreeable, well-known hetero- and/or homometallic oxalate compounds or iii) solid state solutions of two appropriate mixed-metal oxides, the band gaps and photocatalytic activity will be determined, as also characterization from magnetic and electrical points of view. ]]></summary_en></project><project>
<id>8736</id><title_hr><![CDATA[Europski režim iregulariziranih migracija na periferiji EU: od etnografije do pojmovnika]]></title_hr><title_en><![CDATA[The European Irregularized Migration Regime in the Periphery of the EU: from Ethnography to Keywords]]></title_en><user_id>19338</user_id><user_firstLast_name>Marijana  Hameršak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-6642</code><acronim><![CDATA[ERIM]]></acronim><duration>01.02.2020 - 15.06.2024</duration><status>Završio</status><financ_value>72.034,90 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Etnologija i antropologija, </scie_field_hr><scie_field_en>Ethnology and anthropology, </scie_field_en><institution_hr><![CDATA[Institut za etnologiju i folkloristiku]]></institution_hr><institution_en><![CDATA[Institute of Ethnology and Folklore Research in Zagreb]]></institution_en><team_members_id>11205, 25821, 25858, 911, 7737, 25145, 25837, 20316, 25860, 25827, 856144, </team_members_id><team_members_names><![CDATA[Tea Škokić, Teodora Jovanović, Uršula Lipovec Čebron, Mojca Piškor, Iva Pleše, Romana Pozniak, Marta Stojić Mitrović, Drago Župarić-Iljić, Jelka Zorn, Duško Petrović, Bojan Mucko, ]]></team_members_names><keywords_hr><![CDATA[balkanska ruta, Europska unija, granice, iregularnost/iregularizacija, migracije, multilokalna etnografija, periferija, režim migracija ]]></keywords_hr><keywords_en><![CDATA[Balkan route, borders, European Union, irregularity/irregularization, migration regime,  migration, multi-sited ethnography, periphery]]></keywords_en><summary_hr><![CDATA[Europski režim migracija i iregularizirana migrantska kretanja, pa tako i ona balkanskom rutom koja presijeca i Hrvatsku, ključni su fenomeni današnjice koji zahtijevaju i znanstvenu elaboraciju. Istraživanje tih fenomena, osobito na jugoistočnim granicama Europske unije, obilježeno je unutrašnjom disperziranošću, tematskom fragmentiranošću te nedovoljnom društvenom i međunarodnom vidljivošću. Stoga se već dulje uočava potreba za stvaranjem jake istraživačke grupe koja bi kontinuirano pratila i analizirala režim iregulariziranih migracija u transnacionalnom prostoru koji zahvaća Hrvatsku i zemlje okružja, a oblikovan je često cirkularnim migrantskim kretanjima.  Projektom ERIM teži se odozdo, polazeći  od multilokalnih etnografskih terenskih istraživanja metodama promatranja, sudjelovanja, intervjua i dr., zahvatiti razine i iskustva različitih dionika, od  migranata, preko članova lokalnih zajednica do zaposlenika i predstavnika tijela lokalnih vlasti, međunarodnih i drugih organizacija. U otklonu od razumijevanja režima migracija kao označitelja apstraktne i monolitne moći države, ERIM, dakle, režimu iregulariziranih migracija  pristupa kao dinamičnom polju heterogenih, pa i suprotstavljenih praksi i interakcija različitih aktera, koje se pritom na specifične načine artikuliraju na periferijama EU. Cilj projekta je višerazinski dokumentirati i istražiti te specifičnosti i ponuditi njihove empirijski utemeljene i teorijski relevantne konceptualizacije. Očekivanim rezultatima (prije svega pojmovnikom tj. mrežom etnografski dokumentiranih i analitički elaboriranih pojmova u okviru pojedinačnih znanstvenih radova, projektne publikacije, kao i multimedijalne mrežne platforme e-ERIM) nastojat će se pridonijeti dubljem razumijevanju kontradikcija i potencijala pojma režima migracija i iregulariziranih migrantskih kretanja u akademskoj, ali i široj društvenoj sferi.]]></summary_hr><summary_en><![CDATA[The European migration regime and irregularized migration movements, including those along the Balkan route that crosses Croatia, among other countries, are key contemporary phenomena that require academic study. Research into these phenomena, especially at the southeastern borders of the EU, has been characterized by internal dispersion, thematic fragmentation and insufficient social and international visibility. Therefore, a need to form a strong research group, which would continuously document and analyze the irregularized migration regime in the transnational space that includes Croatia and the surrounding countries and is shaped by often circular migrant movements, has been evident for some time now. Based on multi-sited ethnographic fieldwork (observation, participation, interviews and other methods), the ERIM project aims to encompass the levels and experiences of different stakeholders, from migrants, to members of local communities, and employees and representatives of local authorities, international and other organizations. By distancing from the notion that the migration regime is a signifier of the abstract and monolithic power of the state, ERIM approaches the irregularized migration regime as a dynamic field of heterogeneous and even opposed practices and interactions of various actors that are articulated in specific ways on the peripheries of EU. The goal of the project is to document and explore these specifics on multiple levels, and to offer their empirically based and theoretically relevant conceptualizations. The expected outcomes (primarily, the keywords i.e. a network of analytically elaborated concepts within the individual research papers, project publications, and the e-ERIM multimedia platform) will be aimed at contributing to a deeper understanding of the contradictions and potentials of the concept of migration regime and irregularized migrant movements in the academic, but also in the broader social sphere.]]></summary_en></project><project>
<id>8737</id><title_hr><![CDATA[Robotska percepcija stvarnog svijeta: razumijevanje složenih scena]]></title_hr><title_en><![CDATA[Real-World Robot Perception: Understanding of Complex Scenes]]></title_en><user_id>6310</user_id><user_firstLast_name>Robert Cupec</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-6819</code><acronim><![CDATA[COSPER]]></acronim><duration>01.03.2020 - 29.02.2024</duration><status>Završio</status><financ_value>113.690,36 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera Osijek, Fakultet elektrotehnike, računarstva i informacijskih tehnologija Osijek]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Electrical Engineering, Computer Science and Information Technology Osijek]]></institution_en><team_members_id>7327, 21326, 6349, 5672, 862760, 865032, </team_members_id><team_members_names><![CDATA[Ivan Vidović, Petra Pejić, Ratko Grbić, Damir Filko, Matej Džijan, Valentin Šimundić, ]]></team_members_names><keywords_hr><![CDATA[robotika, računalni vid, prepoznavanje objekata, razumijevanje slike, učenje robota od strane čovjeka]]></keywords_hr><keywords_en><![CDATA[robotics, computer vision, object recognition, image understanding, robot training by human instructor]]></keywords_en><summary_hr><![CDATA[Sposobnost prepoznavanja objekata od interesa u složenim scenama te identificiranja njihovih dijelova relevantnih za rješavanje određenog zadatka predstavlja jednu od osnovnih funkcionalnosti inteligentnih robota namijenjenih radu u stvarnom svijetu. Mada je prepoznavanje objekata poznatog oblika dobro istražen problem za koji su ponuđena mnoga rješenja, prepoznavanje prvi put viđenih pripadnika određene prethodno naučene klase objekata na složenim scenama još je uvijek izazovan problem. Pored same detekcije objekata od interesa, za robotiku je od posebnog interesa identifikacija dijelova objekata relevantnih za obavljanje određenih zadataka. U predloženom projektu istraživat će se prepoznavanje objekata od interesa i njihovih dijelova na složenim scenama s ciljem razvoja novih kompetitivnih pristupa. Osim prepoznavanja objekata koji predstavljaju kruta tijela, razvijat će se i algoritmi za prepoznavanje artikuliranih objekata, tj. objekata sastavljenih od više krutih tijela povezanih gibljivim zglobovima, kao što su ormarići s ladicama, prozori, vrata, roboti itd., te estimacije njihovih kinematičkih parametara. Istraživat će se mogućnost prenošenja naučenog znanja o mogućnostima promjene konfiguracije artikuliranih objekata na druge pripadnike iste klase objekata. Također će se istraživati i strategije aktivnog vida, koje omogućuju povećanje uspješnosti prepoznavanja objekata odgovarajućim pozicioniranjem kamere montirane na robotski manipulator te interakcijom robota i objekta prepoznavanja. Treća tema predloženog projekta je učenje robota da obavlja neku radnju kroz demonstraciju od strane čovjeka. Razvijat će se metode koje omogućuju prilagodbu naučene radnje na različite objekte i različite situacije. Za rješavanje navedenih problema, koristit će se neuronske mreže i metodologija zasnovana na poliedarskim modelima klasa oblika, razvijena u okviru prethodnog projekta implementiranog od strane prijavitelja ovog projekta i njegovog istraživačkog tima. ]]></summary_hr><summary_en><![CDATA[Ability to recognize objects of interest in complex scenes as well as to identify their parts relevant for solving a particular task is one of the basic functionalities of intelligent robots designed to operate in the real world. Although recognition of objects of known and rigid shape is a thoroughly studied problem, for which a number of solutions are proposed, recognition of previously unseen objects, which are members of previously learned object classes, in complex scenes is still a challenging problem. Besides detection of objects of interest, a subject of special importance for robotics is identification of object parts relevant for solving a particular task. In the proposed project, recognition of objects of interest and their parts in complex scenes will be addressed, with the aim of developing novel competitive approaches. The second research topic of the project is development of novel methods for recognition of articulated objects, i.e. objects built from several rigid bodies connected by movable joints, such as drawers, doors, windows, robots etc., and estimation of their kinematic parameters. We will investigate possibilities of transferring learned knowledge about changing configurations of articulated objects from few representatives to other members of the same object class. Furthermore, active vision strategies will be studied, aimed at improving the object recognition performance by optimal positioning of the camera mounted on a robot arm and interaction between the robot and the target object. The third topic of the proposed project is training a robot to perform certain actions by demonstration performed by a human instructor. We will develop methods which allow adaptation of a learned action to different objects and different situations. For solving the addressed problems, we will use neural networks and the methodology based on polyhedral shape class model, developed in a previously implemented project of the applicant.]]></summary_en></project><project>
<id>8738</id><title_hr><![CDATA[Uspostava kriterija za vrednovanje modernizacijskih i (post)tranzicijskih procesa u ruralnim prostorima Hrvatske kroz studiju slučaja ruralnog prostora Like]]></title_hr><title_en><![CDATA[Establishing Criteria for the Evaluation of Modernization and (Post-)Transition Processes in Croatian Rural Areas Through a Case Study of the Rural Lika Area]]></title_en><user_id>21224</user_id><user_firstLast_name>Anita Bušljeta Tonković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2019-04</proposal_call><code>UIP-2019-04-3024</code><acronim><![CDATA[RURALIKA]]></acronim><duration>01.02.2020 - 28.02.2026</duration><status>U tijeku</status><financ_value>83.708,28 eur</financ_value><scie_area_hr>Društvene znanosti, Humanističke znanosti, Interdiciplinarne znanosti, </scie_area_hr><scie_area_en>Social sciences, Humanities, Interdisciplinary scientific area, </scie_area_en><scie_field_hr>Interdisciplinarne društvene znanosti, Sociologija, Demografija, Povijest, Geografija, </scie_field_hr><scie_field_en>Interdisciplinary social sciences, Sociology, Demography, History, Geography, </scie_field_en><institution_hr><![CDATA[Institut društvenih znanosti Ivo Pilar]]></institution_hr><institution_en><![CDATA[Institute of Social Sciences Ivo Pilar in Zagreb]]></institution_en><team_members_id>25731, 25937, 3472, 1394, 862786, 866722, </team_members_id><team_members_names><![CDATA[Ivan Brlić, Nataša Bokan, Ivan Šulc, Slaven Gašparović, Ema Bašić, Adrian Knežević, ]]></team_members_names><keywords_hr><![CDATA[kriteriji vrednovanja, Lika, modernizacija, (post)tranzicija, ruralni prostor ]]></keywords_hr><keywords_en><![CDATA[evaluation criteria, Lika, modernization, (post-)transition, rural areas]]></keywords_en><summary_hr><![CDATA[Cilj projekta je uspostava idealtipskih interdisciplinarnih kriterija za vrednovanje modernizacijskih i (post)tranzicijskih procesa u ruralnim prostorima Hrvatske na temelju studije slučaja ruralnog prostora Like. Predložena tema istražit će se uz pomoć suvremenih teorija modernizacije i teorija razvoja, inovativnim pristupom u metodologiji koji se temelji na mješovitim metodama, a razmatra utjecaj (zakašnjelih) procesa modernizacije i (post)tranzicije na ruralne prostore u Hrvatskoj. Ti procesi bit će istraženi uz pomoć analize povijesnih izvora, demografskih podataka, pokazatelja iz područja gospodarstva, te kroz kvalitativno istraživanje – provedbu dvjesto polustrukturiranih intervjua (mikro-etnografija u dva kruga istraživanja i četiri etape) na nacionalnoj razini. Projekt se temelji na pretpostavci da utvrđeni i znanstveno valorizirani negativni modernizacijski i (post)tranzicijski procesi konkretnoga ruralnog prostora mogu poslužiti kao laboratorij za istraživanje ostalih ruralnih prostora, kako onih u kojima su uznapredovali isti procesi, tako i onih čiji su osnovni pokazatelji pozitivni. Stoga će ishodi projekta biti relevantni unutar konteksta razvojnih politika te se očekuje da značajno doprinesu socioekonomskom razvoju ruralnih prostora u Hrvatskoj.]]></summary_hr><summary_en><![CDATA[The aim of the project is to establish ideal-type interdisciplinary criteria for evaluating modernisation and (post-)transition processes in Croatian rural areas based on a case study of the rural Lika area. The proposed subject will be studied by employing contemporary modernization theories and development theories, in which an innovative approach to methodology based on mixed methods will be used. The topic that will be researched is the effect of (delayed) modernization and (post-)transition processes on Croatian rural areas. These processes shall be studied by analysing historical sources, demographic data, economic indicators and through a qualitative research: by conducting two hundred semi-structured interviews (microethnography – four stages of research in two rounds) at the national level. The project is based on the assumption that known and scientifically evaluated negative modernization and (post-)transition processes of a concrete rural area can serve as a laboratory for studying other rural areas, both the areas in which the mentioned process have significantly developed, and those areas whose basic indicators are positive. Therefore, the results of the project shall be relevant with regard to development policies and they are expected to significantly contribute to the socio-economic development of Croatian rural areas.]]></summary_en></project><project>
<id>8739</id><title_hr><![CDATA[Epigravetijenske zajednice sjeverne Dalmacije]]></title_hr><title_en><![CDATA[Epigravettian communities of Northern Dalmatia]]></title_en><user_id>499</user_id><user_firstLast_name>Dario Vujević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-6115</code><acronim><![CDATA[EpiC]]></acronim><duration>01.02.2020 - 31.01.2024</duration><status>Završio</status><financ_value>79.532,82 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Arheologija, </scie_field_hr><scie_field_en>Archeology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zadru]]></institution_hr><institution_en><![CDATA[University of Zadar]]></institution_en><team_members_id>23881, 12898, 2993, 19351, 23723, 12720, 2744, 6111, 26023, 5386, 865397, </team_members_id><team_members_names><![CDATA[Emanuela Cristiani, Mario Bodružić, Barbara Cvitkušić, Martina Dubolnić Glavan, Selena Vitezović , Zlatko Perhoč, Siniša Radović, Mate Parica, Maja Grgurić, Giovanni Boschian, Niccolo Mazzucco, ]]></team_members_names><keywords_hr><![CDATA[Vlakno, Gornji paleolitik, epigravetijen, pleistocen, litika, nakit, koštani alat]]></keywords_hr><keywords_en><![CDATA[Vlakno cave, Upper Palaeolithic, Epigravettian, Pleistocene, Lithic, personal ornaments, bone tools]]></keywords_en><summary_hr><![CDATA[Razdoblje gornjeg paleolitika na području sjeverne Dalmacije izrazito je slabo istraženo. Situacija nije bolja niti ako u obzir uzmemo širi prostor istočnog Jadrana, gdje postoji svega desetak dovoljno istraženih nalazišta iz vremena epigravetijena. Uz to, tek mali broj nalazišta na istočnoj obali Jadrana mogu se datirati u vrijeme starije od 13,000 god. prije sadašnjosti, a posebno su rijetka nalazišta koja se mogu datirati u vrijeme trajanja ili neposredno nakon kasnoglacijalnog maksimuma. Pećina Vlakno na Dugom otoku jedno je od rijetkih koje ima kulturne slojeve iz ovih razdoblja. Nova istraživanja kako u pećini Vlakno, tako i na drugim projektom predloženim lokacijama doprinijet će stoga proučavanju gornjeg paleolitika jugoistočne Europe. Sa znanstvene strane istraživanja će pomoći u definiranju načina na koji su ljudske zajednice mijenjale svoje ponašanje i pružiti važne informacije na temu naseljavanja i kretanja zajednica u razdoblju posljednjeg ledenog doba. Pomoći će u definiranju načina na koji su ljudske zajednice mijenjale svoje ponašanje i pružiti važne informacije na temu naseljavanja i mobilnosti zajednica. Dobiveni podatci lako će se moći inkorporirati u druga slična istraživanja na širem prostoru i tako popuniti praznine koje su do sada postojale vezane uz razdoblje epigravetijena.]]></summary_hr><summary_en><![CDATA[Current state of research of the Northern Dalmatia is quite limited. The situation is not even better if we take the wider area of the eastern Adriatic in consideration. In the eastern Adriatic region there are about ten Epigravettian sites explored in a satisfying manner. Only a small number of sites on the eastern coast of the Adriatic can be dated to the period before 13,000 bp, and sites which can be dated to the period of duration or immediately after the Late Glacial Maximum are particularly rare. Vlakno on the island of Dugi Otok is one of them. New research in the Vlakno Cave and other proposed locations will contribute to the study of the Upper Palaeolithic of Southeast Europe. From the scientific side of the research, it will help define the ways in which human groups have changed their behaviour and provide important information on the questions of communities mobility in the period of the Last Ice Age. The obtained data will easily be incorporated into other similar research in the wider space and thus fill the gaps that have so far been associated with the Epigrevattian period.]]></summary_en></project><project>
<id>8744</id><title_hr><![CDATA[Redukcija vibracija u mehaničkim sustavima]]></title_hr><title_en><![CDATA[Vibration Reduction in Mechanical Systems]]></title_en><user_id>844</user_id><user_firstLast_name>Zoran Tomljanović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-6774</code><acronim><![CDATA[VIMS]]></acronim><duration>01.01.2020 - 31.12.2023</duration><status>Završio</status><financ_value>115.137,04 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Fakultet primijenjene matematike i informatike]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, School of Applied Mathematics and Informatics]]></institution_en><team_members_id>25877, 838, 883, 855851, 865005, </team_members_id><team_members_names><![CDATA[Serkan Gugercin, Ivana Kuzmanović Ivičić, Suzana Miodragović, Marinela Pilj Vidaković, Ranjan Kumar Das, ]]></team_members_names><keywords_hr><![CDATA[mehanički sustav,  redukcija vibracija, kvadratni svojstveni problem, izolacija frekvencija, model reduciranog reda, optimizacija parametara]]></keywords_hr><keywords_en><![CDATA[mechanical system, vibration reduction, quadratic eigenvalue problem, frequency isolation, reduced-order model, parameter optimization]]></keywords_en><summary_hr><![CDATA[Analiza i redukcija vibracija u mehaničkom sustavu istaknuti su problemi u brojnim istraživačkim poljima. Iako je analiza vibracija sustava tema koja je intenzivno proučavana u skorijim desetljećima, mnogi problemi su i dalje otvoreni. Slučaj kada nema vanjskog podražaja vodi do proučavanja homogenih sustava, a s druge strane postojanje vanjske sile vodi do proučavanja nehomogenog sustava. U ovisnosti o prisustvu vanjske sile i primjenama, mi ćemo proučavati četiri istraživačke teme.Unutar prve teme proučavat ćemo teorijske rezultate relevantne za redukciju vibracija u mehaničkim sustavima.  Planiramo razviti teorijske rezultate koji karakteriziraju važna svojstva kvadratnog svojstvenog problema (QEP) koji se pojavljuje u analizi titranja mehaničkih sustava. Unutar druge istraživačke teme razvit ćemo nove metode za izolaciju frekvencija i pri tome koristit ćemo metode bazirane na algoritmima za ne-glatku optimizaciju. U ovom slučaju razvit ćemo nove algoritme koji čuvaju strukturu matrica kao i svojstva promatranog svojstvenog problema. U trećoj istraživačkoj temi promatrat ćemo redukciju vibracija baziranu na novim kriterijima koji koriste norme sustava (npr. H2 i Hinf) za sustav sa više ulaza i više izlaza. Također, proučavat ćemo pristupe za aproksimaciju modela punog reda modelom reduciranog reda koji zadržava strukturu parametarske ovisnosti. Novi pristupi će biti dobro prilagođeni za efikasnu optimizaciju parametara i proučavanje važnih svojstava sustava. U četvrtoj istraživačkoj temi proučavat ćemo integraciju istraživačkih tema I-III i primjenu u stvarnim primjerima. Nadalje, primjenit ćemo nove pristupe i algoritme u različitim akademskim primjerima, ali također i u stvarnim primjerima iz života koji se pojavljuju, npr. u auto industriji (poput problema kočionog diska), građevinskim konstrukcijama (poput greda i građevina), itd. Stoga, rezultati iz ovog projekta mogli bi imati široku primjenu.]]></summary_hr><summary_en><![CDATA[Vibration analysis and vibration reduction for mechanical systems are prominent problems in numerous research fields. Although the vibrations analysis is an intensively studied topic in recent decades, many problems still remain open. While the case without external excitation leads to the study of homogeneous systems, presence of an external forcing leads to the study of  nonhomogeneous systems. Depending on the presence of an external excitation and applications, we will consider four different research themes. Within the first research theme, we will study theoretical results that are relevant for vibration reduction. We plan to develop theoretical results that characterize important properties of the quadratic eigenvalue problem (QEP) arising from vibration analysis of mechanical systems. Within the second research theme we will develop new methods for frequency isolation and utilize methods which are based on algorithms for non-smooth optimization. For this case we will derive new algorithms that preserve the structure of the matrices and structural properties of the considered QEP. In the third research theme, we will consider vibration reduction based on criteria that use system norms (e.g. H2 and Hinf) for Multiple-Input Multiple-Output case. We will also study approaches for approximating the full-order model with a reduced-order model that retains the structure of parametric dependence. The new approaches will be well suited for computationally efficient parameter optimization and the study of important system properties. In the fourth research theme we will consider integrating research themes I-III and applications in real world examples. Moreover, we will apply obtained new approaches and algorithms in various academic examples, but also in real life examples that arise, e.g., in car industry (such as disc brake problem) and civil engineering (such as beams, civil buildings), etc.  Therefore, the results from this project could have wide applications.]]></summary_en></project><project>
<id>8747</id><title_hr><![CDATA[Taložni paleobazeni, vodeni prolazi i migracije biote]]></title_hr><title_en><![CDATA[Sedimentary paleobasins, water corridors and biota migrations]]></title_en><user_id>13393</user_id><user_firstLast_name>Marijan Kovačić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-7042</code><acronim><![CDATA[SEDBAS]]></acronim><duration>01.01.2020 - 30.04.2024</duration><status>Završio</status><financ_value>123.867,68 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Geologija, </scie_field_hr><scie_field_en>Geology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>1478, 6680, 25978, 25980, 13361, 13375, 3521, 4262, 26267, 23725, 26286, 5741, 22722, 22775, 865217, </team_members_id><team_members_names><![CDATA[Jasenka Sremac, Đurđica  Pezelj, Karmen Fio Firi, Katarina Gobo, Frane Marković, Davor Pavelić, Valentina Hajek-Tadesse, Anita Grizelj, Marija Bošnjak, Stjepan Coric, Vibor Novak, Morana Hernitz Kučenjak, Mario Matošević, Tomislav Kurečić, Valerije Makarun, ]]></team_members_names><keywords_hr><![CDATA[paleobazeni, vodeni prolazi, migracija biote, Krški Dinaridi, Centralni Paratethys]]></keywords_hr><keywords_en><![CDATA[paleobasins, water corridors, biota migration, Karst Dinarides, Central Paratethys]]></keywords_en><summary_hr><![CDATA[Živi svijet osjetljiv je na promjene okolišnih uvjeta. One utječu na prilagodbe, migracije i nastanak novih vrsta, a mogu dovesti i do izumiranja. Stijene sadrže dokaze o takvim zbivanjima u geološkoj prošlosti, fosile. Na području Hrvatske postoje stijenski zapisi o razvoju biote iz različitih životnih okoliša: od oceanskih i morskih, preko bočatih do slatkovodnih i kopnenih. Najstariji se nalaze u paleozojskim naslagama, a mogu se pratiti kroz mezozoik i kenozoik sve do danas. Posebno su zanimljive stijene gornjopaleozojsko-trijaskih oceanskih okoliša te neogenskih epeiričkih i jezersko-kopnenih bazena. U permu su zabilježene globalne krize na granici gvadalupija i lopingija, te, najveće izumiranje ikad, na prijelazu iz perma u trijas. Tragovi tih događaja nalaze se u stijenama naših Dinarida. S druge strane, razvoj neogenskoga epikontinentalnog Paratethys mora (danas u sjevernoj Hrvatskoj), uspostave i prekidi njegovih veza sa svjetskim morima i oceanima, prelazak u jezero, zapunjavanje jezera i formiranje kopna, utjecali su na biotu kroz njezinu radijaciju i diverzifikaciju, migraciju, izumiranje i pojavu endemizma. Suvremenim terenskim i laboratorijskim metodama, koje uključuju radiometrijsko datiranje naslaga, interpretaciju taložnih okoliša i njihove promjene kroz vrijeme te utjecaj čimbenika kao što su eustatska kolebanja, sinsedimentacijska tektonika, klimatske promjene i vulkanizam na bazene i biotu, istražit će se gornjopaleozojske i trijaske stijene na području Krških Dinarida te neogenske naslage u Sjeverozapadnoj Hrvatskoj, na prostoru Slavonskih gora i na Banovini. Ciljevi istraživanja uključuju odredbu vremenskoga okvira pojedinih događaja, rekonstrukciju razvoja i međusobne povezanosti taložnih bazena te utjecaj intrabazenskih i ekstrabazenskih čimbenika na bazene i živi svijet u njima. Istraživanjima će se nadopuniti znanja o globalnim i lokalnim, postupnim i iznenadnim stresnim događajima, njihovoj kronologiji i utjecaju na taložne bazene i biotu.]]></summary_hr><summary_en><![CDATA[Living biota are sensitive to changes in enivironmental conditions. They affect the adaptations, migrations and new species development, and can lead to the extinction of species. Evidence of such geological events are fossils, found in rocks. Fossil biota in Croatia lived in different environments: ocean, marine, brackish, freshwater and terrestric. The oldest fossils are recorded in Paleozoic rocks, and are present in Mesozoic and Cenozoic rocks up to the present day. Of great interest are Upper Paleozoic-Triassic ocean environments and Neogene epeiric and lacustrine-land basins. Permian global crises are recorded at the Guadalupian-Lopingian transition and, the greatest extinction ever, at the Permian-Triassic transition. Traces of these events are found in Croatian Dinarides. Fossil biota changes are also influenced by development of the Neogene epicontinental Paratethys sea (today&#39;s area of Northern Croatia), opening and closing of marine gateways, transition of marine into lacustrine environments, changes in basin infill and mainland formation. Changes reflected in biota radiation and diversification, migration, extinction and endemism. Upper Paleozoic-Triassic rocks from Karst Dinarides and Neogene deposits from Northwestern Croatia, Slavonia hills area and Banovina will be analyzed by applying the recent field and laboratory methods, including absolute dating, depositional environment interpretations well as the tracing the impact of eustatic fluctuations, sinsedimentary tectonics, climate changes and volcanism on basins and biota. The research goal is to determine the age of each of the above mentioned events, reconstruct the basins development and connections, and to determine the intrabasinal and extrabasinal influence on deposition and biota. The proposed research project will upgrade the knowledge of global and local, gradual and sudden stress events, their chronology and impact on depositional basins and biota. ]]></summary_en></project><project>
<id>8750</id><title_hr><![CDATA[Varijacije u broju kopija uzrokovane okolišem u mišjim spermijima]]></title_hr><title_en><![CDATA[Environmentally induced copy number variation in mouse sperm cells]]></title_en><user_id>1280</user_id><user_firstLast_name>Zeljka Pezer Sakac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2019-04</proposal_call><code>UIP-2019-04-7898</code><acronim><![CDATA[iCNV]]></acronim><duration>15.06.2020 - 14.12.2025</duration><status>U tijeku</status><financ_value>249.688,10 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>26678, 855849, 867481, 25111, </team_members_id><team_members_names><![CDATA[Jun Wang, Ivan Pokrovac, Mateja Janeš, Sunčica Stipoljev, ]]></team_members_names><keywords_hr><![CDATA[varijacije broja kopija, CNVs, replikacijski stres, de novo CNVs, sekvenciranje pojedinačnih stanica, spermiji, genomski poremećaji, miš]]></keywords_hr><keywords_en><![CDATA[copy number variation, CNVs, replication stress, de novo CNVs, single-cell sequencing, sperm cells, genomic disorders, mouse]]></keywords_en><summary_hr><![CDATA[Varijante broja kopija (engl. Copy Number Variants; CNVs) su najčešći oblik genetske varijacije, u smislu brzine mutacije i udjela genoma koji obuhvaćaju, te stoga imaju značajan utjecaj na zdravlje i evoluciju. Unatoč tome, nejasno je kako na varijante broja kopija i njihovu stopu mutacije utječu okolišni čimbenici. Studije koje se temelje na populacijskim genomskim analizama nisu u stanju detektirati de novo CNVs sve dok one nisu prisutne u većoj frekvenciji u populaciji. Stoga se utjecaj okoliša može pretpostavljati samo za varijante koje su manje ili više fiksirane u određenoj populaciji. Štoviše, ove analize kao i analize obitelji se redovito provode na diploidnim genomima iz somatskih tkiva, prilikom čega je nejasan broj kopija pojedinog alela. To onemogućava točne procjene učestalosti i brzine mutacije, povezivanje specifičnih varijanti s bolestima i poremećajima i detekciju utjecaja okolišnih čimbenika. Kako bi se prevladali ovi problemi, ovdje predloženo istraživanje ispitat će utjecaj nekoliko okolišnih čimbenika na frekvenciju CNVs u pojedinačnim spermijima, pomoću najnovije tehnologije istovremenog sekvenciranja genoma iz tisuća stanica. Osim toga, pomoću sekvenciranja i analize transkriptoma, ispitat ćemo mogu li jaki transkripcijski odgovori na okolišne čimbenike tijekom spermatogeneze stimulirati varijacije broja kopija na induciranim regijama putem replikacijskog stresa. Procijenit će se frekvencija varijanti vezanih za specifične okolišne uvjete, od kojih su mnogi povezani s kompleksnim poremećajima, te će tako rezultati doprinijeti razumijevanju mehanizma nastanka bolesti. Mišji soj koji će se koristiti u ovom istraživanju jedan je od glavnih genetičkih i biomedicinskih modela, pa se očekuje da će rezultati biti primjenjivi na ljude. Predloženi projekt predstavlja originalan pristup u istraživanju brzine mutacije CNVs, s potencijalom za dosad najvišu osjetljivost de novo CNV detekcije i razlučivanja interakcija između okoliša i genoma.]]></summary_hr><summary_en><![CDATA[Copy number variants (CNVs) are the most prevalent form of genetic variation, in terms of mutation rate and the fraction of the genome that they affect, thus having substantial impact on health and evolution. Despite of that, it is unclear how CNVs and their mutation rates are influenced by environmental factors. Studies that are based on population genomic analyses are unable to detect de novo CNVs until present at high frequency, so the environmental influence can only be speculated for CNVs which are more or less fixed in a particular population. Moreover, these analyses as well as analyses of families are readily performed on genomes from somatic tissues, providing only diploid copy number and leaving allelic copy numbers unknown. This precludes accurate estimates of CNV frequency and mutation rates, disease associations and environmental influence. To overcome these issues, the research proposed here will investigate the effect of several environmental factors on CNV frequency in single sperm cells, by using the most recently developed technology of simultaneous genome sequencing of thousands of cells. Additionally, by performing high throughput RNA sequencing, we will examine whether strong transcriptional responses invoked by environmental factors during spermatogenesis may promote CNVs at induced loci through replication stress. The project will estimate the frequency of CNVs linked to specific environmental exposures, many of which are suggested to associate with genomic disorders, hence contributing to the understanding of disease onset and pathogenesis. Given that the mouse strain used in this study is one of the major mammalian genetic and biomedical research models, the results are expected to be highly relevant to humans. The proposed research represents an original approach into the study of CNV mutation rate, with potential to provide unprecedented power of de novo CNV detection and resolution of environment-genome interactions.]]></summary_en></project><project>
<id>8761</id><title_hr><![CDATA[Doprinos religijskog obrazovanja suživotu u multikulturalnome društvu]]></title_hr><title_en><![CDATA[The Contribution of Religious Education to Coexistence in the Multicultural Society]]></title_en><user_id>26133</user_id><user_firstLast_name>Ružica Razum</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-3661</code><acronim><![CDATA[RELIGOBRAZ]]></acronim><duration>15.01.2020 - 14.01.2024</duration><status>Završio</status><financ_value>91.030,73 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Teologija, </scie_field_hr><scie_field_en>Theology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Katolički bogoslovni fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Catholic Faculty of Theology]]></institution_en><team_members_id>26231, 26155, 26785, 26175, 27252, 26540, 26727, 26735, 26135, 855681, 862784, 862759, </team_members_id><team_members_names><![CDATA[Blaženka Valentina Mandarić, Ana Thea Filipović, Juro Zečević-Božić, Jadranka Garmaz, Edina Vejo, Nenad Malović, Tomislav Kovač, Denis Barić, Gordana Barudžija, Marija  Jurišić, Kristina Vujica, Tomislav Šegina, ]]></team_members_names><keywords_hr><![CDATA[religijsko obrazovanje, hrvatski odgojnoobrazovni sustav, odgoj za suživot, interkulturalnost, nastavničke kompetencije]]></keywords_hr><keywords_en><![CDATA[religious education, Croatian educational system, education to coexistence, interculturality, teaching competences]]></keywords_en><summary_hr><![CDATA[U istraživačkome žarištu projekta nalazi se pojava multikulturalnih društvenih struktura koje mijenjaju odnose među ljudima te otvaraju za odgoj i obrazovanje mnoga pitanja. Hrvatska, kao dio europskoga prostora, suočena je sa sve većim razvojem komunikacijskih tehnologija, globalizacijom, migracijskim procesom i izbjegličkom krizom. Osim toga, Hrvatska ima veoma poseban geografsko-povijesni položaj. Nadalje, živi u konfliktnom postratnom kontekstu opterećenom bolnim ratnim iskustvima čije posljedice dodatno otežavaju suživot. Svi ti čimbenici i procesi zahtijevaju interkulturalni odgojno-obrazovni napor (naučiti živjeti zajedno), koji nužno uključuje i religijsku dimenziju kao bitan element kulture. Školi pripada osobito važno mjesto i odgovornost za promicanje dijaloga, nužnog preduvjeta mira i suživota.Cilj je projekta istražiti doprinos religijskoga obrazovanja u školama u Hrvatskoj odgoju i obrazovanju za suživot u multikulturanome društvu. Taj će se doprinos istražiti na dvije razine: na razini kurikuluma predmeta koji posreduju religijska znanja u osnovnoj i u srednjoj školi; na razini interkulturalnih kompetencija samih nastavnika. Istraživanje uključuje analizu dokumenata važnih za razumijevanje interkulturalnog i međureligijskog odgoja i obrazovanja. Nadalje, uključuje komparativnu analizu kurikuluma konfesionalnoga religijskoga obrazovanja u osam europskih zemalja s ciljem da se upoznaju temeljni interkulturalni / međureligijski ciljevi i sadržaji. Predmet istraživanja su također kurikulumi katoličkog, pravoslavnog i islamskog vjeronauka u RH. Predmet istraživanja su isto tako predmeti i međupredmetne teme koji posreduju religijsko znanje kao dio interkulturalnoga odgoja i obrazovanja. Unutar istraživanja provest će se i empirijsko istraživanje o stavovima nastavnika o međureligijskome obrazovanju u katoličkoj, pravoslavnoj i islamskoj vjeronaučnoj nastavi. Provest će se i analiza studijskih programa koji osposobljavaju buduće nastavnike vjeronauka.]]></summary_hr><summary_en><![CDATA[In the research focus of this project is the appearance of multicultural social structures that change the relations between people and open up many questions for education. Croatia has a very specific geographic-historical position. Through centuries of existence at the intersection of a number of various cultures and religions, Croatia has been strongly marked by a variety of complex historical, socio-cultural, and religious features. Furthermore, Croatia lives in a conflict post-war context burdened with extremely painful war experiences with consequences that additionally complicate coexistence. All those factors and processes required an intercultural educational effort, which necessarily includes the religious dimension as a significant element of culture.The objective of this project is to investigate the contribution of religious education in elementary and secondary schools in Croatia to the education for coexistence in modern multicultural society. That contribution will be investigated at two levels: at the level of curricula of school subjects that mediate religious knowledge in elementary and secondary schools; at the level of competences of teachers on whom the promotion of intercultural/interreligious education depends the most. Research includes an analysis of fundamental European, Croatian, and documents of the Catholic Church significant for understanding intercultural and interreligious education. Furthermore, it includes a comparative analysis of the curricula of confessional religious education in 8 European countries. An object of this research is also the new curricula of Catholic, Orthodox, and Islamic religious education in Croatia. An object of this research is also school subjects and inter-curricular subjects that are part of the social-humanistic area. Empirical research will also be conducted within this research, with the objective of investigating attitudes of teachers about the interreligious dialogue.]]></summary_en></project><project>
<id>8764</id><title_hr><![CDATA[Izazovi alternativnih oblika ulaganja]]></title_hr><title_en><![CDATA[Challenges of Alternative Investments]]></title_en><user_id>4833</user_id><user_firstLast_name>Zdravka Aljinović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-7816</code><acronim><![CDATA[CRYPRO]]></acronim><duration>01.01.2020 - 31.12.2023</duration><status>Završio</status><financ_value>49.333,07 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, </scie_field_hr><scie_field_en>Economy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Ekonomski fakultet]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Economics, Business and Tourism]]></institution_en><team_members_id>4162, 3912, 26591, 4342, 25753, 865454, 866638, </team_members_id><team_members_names><![CDATA[Branka Marasović, Blanka Škrabić Perić, Ana  Rimac Smiljanić, Tea Šestanović, Ante Toni Vrdoljak, Tea Kalinić Milićević, Ivana Jerković Jerković, ]]></team_members_names><keywords_hr><![CDATA[alternativni oblici ulaganja, kriptovalute, diverzifikacija, institucije, financijska pismenost]]></keywords_hr><keywords_en><![CDATA[alternative investments, cryptocurrencies, diversification, institutions, financial literacy]]></keywords_en><summary_hr><![CDATA[Brojni su izazovi alternativnih oblika ulaganja, a s obzirom na trenutno stanje u području istraživanja, te s obzirom na interese i kompetencije istraživačke grupe, u ovom će se projektu istražiti: Koreliranost prinosa pojedinih alternativnih investicija, posebno kriptovaluta, s prinosima tradicionalnih, ali i drugih alternativnih oblika ulaganja; Doprinos pojedinih alternativnih oblika ulaganja, posebno kriptovaluta u terminima Markowitzeve diverzifikacije - koji od alternativnih oblika imovine i u kojim udjelima najbolje doprinose performansama portfelja, uvažavajući sve prepoznate specifičnosti i ograničenja; Daju li neuronske mreže preciznije prognostičke vrijednosti cijena i volatilnosti odabranih kriptovaluta i koja neuronska mreža je pri tom najprikladnija; Postoji li veza između institucija i tržišta alternativnih ulaganja kao posebnog segmenta tržišta kapitala, postoji li razlika uloge institucija za zemlje u razvoju i razvijene zemlje; Je li financijska pismenost povezana s razvojem alternativnih tržišta, postoji li obostrana uzročnost između tržišta alternativne imovine i financijske pismenosti; Posebno, utječu li više razine financijske pismenosti na participaciju u trgovanju kriptovalutama te u kojoj mjeri razvoj tržišta kriptovaluta potiče sudjelovanje u trgovanju. Za postavljena istraživačka pitanja može se reći da su ili potpuno originalna i do sada neistražena ili je istraživanje po tim pitanjima na začetku, tek parcijalno, s puno prostora za metodološko unaprijeđenje. U uvjetima kada alternativni oblici ulaganja velikom brzinom i sa sve većim volumenima ulaze na financijska tržišta, odgovori na postavljena pitanja, uz uvođenje i implementaciju prikladne metodologije, od velike su važnosti za znanstvenu zajednicu, ali i brojne praktičare, u koje se u suvremenom svijetu ubraja i sve veći dio građanstva koje uviđa i uvažava potrebu za aktivnom brigom o svojoj imovini.]]></summary_hr><summary_en><![CDATA[There are numerous challenges associated with alternative investments, but given the state of research and considering the interests and expertise of the research group, the research issues to be investigated in this project are the following: Correlation of the return of particular alternative investments, especially cryptocurrencies, with the returns of traditional as well as some other alternative investments; Contribution of particular alternative investments, especially cryptocurrencies, in terms of Markowitz’ diversification - which of the alternative forms of assets and in which proportions best contribute to portfolio performance, considering all recognized features and constraints; If neural networks offer more accurate prognostic values of price and volatility of the selected cryptocurrencies and which neural network is the most suitable; The link between institutions and alternative asset market as a separate segment of capital market, the role of institutions in developing and developed countries; The link of financial literacy with the development of alternative markets, the possibility of mutual causality; If a more advanced level of financial literacy effects on participation in cryptocurrencies’ trading, to what extent the development of the cryptocurrency market encourages participation in trading. For all research issues it can be said that they are either original and hitherto unexplored or the existing research is at the beginning, only partial and leaving the space for methodology improvements. Under conditions where alternative forms of investment enter financial markets expeditiously and with increasing volumes, answers to the raised questions and issues, together with introduction and implementation of the most accurate methodology, are of major importance for scientific community, but also for numerous practitioners, including increasingly large number of citizens who recognize the necessity of active asset management approach.]]></summary_en></project><project>
<id>8771</id><title_hr><![CDATA[Nove građevne jedinke u supramolekulskom dizajnu složenih višekomponentnih molekulskih kristala temeljenih na halogenskim vezama]]></title_hr><title_en><![CDATA[New building blocks for the supramolecular design of complex multi-component molecular crystals based on halogen bonds]]></title_en><user_id>356</user_id><user_firstLast_name>Dominik Cinčić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-1868</code><acronim><![CDATA[HaloBond]]></acronim><duration>01.02.2020 - 28.02.2024</duration><status>Završio</status><financ_value>130.984,14 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>310, 12541, 24307, 4525, 13224, 26604, 5861, 29303, 858398, </team_members_id><team_members_names><![CDATA[Vladimir Stilinović, Vinko Nemec, Nikola Bedeković, Nenad Judaš, Tomislav Friscic, Robin Stein, Dejan-Krešimir Bučar, Nea Baus Topić, Lidija Posavec, ]]></team_members_names><keywords_hr><![CDATA[Halogenska veza, metaloorganski materijali, kokristali, supramolekulska kemija, mehanosinteza]]></keywords_hr><keywords_en><![CDATA[Halogen bond, metal-organic materials, cocrystals, supramolecular chemistry, mechanosynthesis]]></keywords_en><summary_hr><![CDATA[Halogenska veza je privlačna interakcija koja se intenzivno proučava u različitim područjima kemije, a ponajviše u kristalnom inženjerstvu. Za sustavno istraživanje halogenskih veza najčešće su primjenjivani organski sustavi s perhalogeniranim spojevima kao donorima halogenske veze, dok su najčešće korišteni akceptori organski spojevi koji sadrže različite funkcijske skupine s dušikom. Skupine s kisikom ili težim atomima kao akceptorima rjeđe su izučavane, a uključuju najviše spojeve sa sumporom te halogenima. Kao nastavak naših ranijih istraživanja u području kristalnog inženjerstva, kojima je uspostavljen preliminarni dizajn kokristala farmaceutskih spojeva temeljnih na halogenskoj vezi te prvi primjeri halogenske veze s teškim pniktogenima (P, As, Sb), ovaj projekt inovira dizajn i sintezu materijala temeljenih na halogenskim vezama te uključuje organsku, koordinacijsku i supramolekulsku kemiju. Projekt se sastoji od tri radne cjeline kojima je zajedničko izučavanje halogenskih veza, dizajn i sinteza: i) ionskih, ii) organskih te iii) metaloorganskih kokristala. Omogućit će: i) razjašnjavanje hijerarhije međumolekulskih interakcija u ionskim kristalima koji se temelje na halogenskoj vezi, ii) otkrivanje novih sintona halogenske veze te razumijevanje njihove fleksibilnosti, iii) istraživanje potencijala anorganskih i organskih aniona kao akceptora, iv) istraživanje potencijala kationskih vrsta kao donora i v) utvrđivanje potencijala težih pniktogena kao akceptora halogenske veze. Očekivani doprinos ovog projekta ponajviše je od fundamentalnog značaja za kristalno inženjerstvo kao i za eksperimentalnu i teorijsku supramolekulsku kemiju u čvrstom stanju. Značajni doprinosi bit će novi smjerovi za pouzdanu sintezu metaloorganskih materijala povezanih halogenskim vezama te u otvaranju novih mogućnosti korištenja halogenskih veza u dizajnu kokristala, višekomponentnih materijala od velikog interesa za razvoj lijekova, agrokemikalija i drugih funkcionalnih materijala.]]></summary_hr><summary_en><![CDATA[The halogen bond (X-bond) is emerging as an attractive interaction, intensely researched across different fields, and especially crystal engineering. Systematic studies of X-bonds are mostly performed using perhalogenated organic compounds as donors, using predominatly nitrogen-based acceptors. Studies with heavier atoms or oxygen as acceptors are less common, largely based on sulphur or halogens. As a continuation of our previous work in crystal engineering, which established preliminary designs for X-bonded pharmaceuticals and demonstrated the first examples of X-bonds to heavy pnictogen acceptors (P, As, Sb), this project will innovate the design and synthesis of materials based on X-bonds, by establishing ways to reliably combine coordination, covalent and supramolecular chemistry. The project is based on 3 work packages focusing on the design and synthesis of: i) ionic, ii) organic, and iii) metal-organic cocrystals. It will contribute by: i) elucidating the hierarchy of supramolecular interactions in X-bonded ionic crystals, ii) discovering new X-bonding synthons and understanding their flexibility, iii) investigating the potential of organic and inorganic anions as acceptors, iv) investigating the potential of cations as donors, and v) establishing the crystal engineering potential of heavy pnictogens as X-bond acceptors. Significant contributions will be new paths for reliable construction of metal-organic materials via X-bonds, and cocrystal-based routes for targeted synthesis of isostructural solids. The expected impact is in fundamental aspects of crystal engineering, as well as experimental and theoretical supramolecular chemistry of solids. The importance lies in opening new opportunities for using X-bonds in the design of cocrystals, i.e. multi-component materials of high interest in developing new pharmaceuticals, agrochemicals, and other functional advanced materials.]]></summary_en></project><project>
<id>8776</id><title_hr><![CDATA[Nanoemulzije unaprijeđene biofarmaceutske vrijednosti za liječenje bolesti suhoga oka]]></title_hr><title_en><![CDATA[Biopharmaceutically improved nanoemulsions for the treatment of dry eye disease]]></title_en><user_id>4075</user_id><user_firstLast_name>Jasmina Lovrić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-2174</code><acronim><![CDATA[BeatDED]]></acronim><duration>01.03.2020 - 30.11.2024</duration><status>Završio</status><financ_value>131.926,47 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Farmacija, </scie_field_hr><scie_field_en>Pharmaceutical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Farmaceutsko-biokemijski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Pharmacy and Biochemistry]]></institution_en><team_members_id>6672, 5296, 17861, 26777, 26770, 26822, 26775, 26778, 26768, 861730, 864848, 864849, </team_members_id><team_members_names><![CDATA[Ivan Pepić, Anita Hafner, Bisera Jurišić Dukovski, Igor Petriček, Marina Juretić, Iva Krtalić, Maša Safundžić Kučuk, Miguel Mano, Reichl Stephan, Josip Ljubica, Ivan Sušanj, Nina Popović, ]]></team_members_names><keywords_hr><![CDATA[bolest suhog oka, nanoemulzije, in vitro biorelevantne metode, razvoj formulacije, biofarmaceutska karakterizacija, oftlamička primjena lijekova]]></keywords_hr><keywords_en><![CDATA[dry eye disease, nano emulsions, in vitro biorelevant methods, formulation development, biopharmaceutical characterisation, ophthalmic drug delivery]]></keywords_en><summary_hr><![CDATA[Bolest suhog oka (engl. dry eye disease, DED) je multifaktorijalna bolest površine oka karakterizirana gubitkom homeostaze suznog filma. Pogađa milijune ljudi širom svijeta sa značajnim utjecajem na kvalitetu života. Prevalencija raste s dobi, no relativno visoke stope prevalencije zabilježene su i u mlađih ispitanika zbog ogromnog porasta uporabe digitalnih uređaja.U/V nanoemulzije (NE), ultrafine disperzije ulja u vodi, imaju veliki potencijal učinkovitog liječenja DED-a. Tijekom protekla dva desetljeća NE se razvijaju kao strategija za poboljšanje bioraspoloživosti imunomodulatora ciklosporina A (CsA) u oku nakon topikalne primjene. CsA se koristi u liječenju težih oblika DED-a, potrebno ga je koristiti dulje vrijeme, a početak djelovanja mu je odgođen. Kratkotrajna premedikacija topikalnim glukokortikoidima ili nesteroidnim protuupalnim lijekovima (NSAID) može osigurati brže otklanjanje simptoma u odnosu na CsA monoterapiju. Štoviše, topikalni glukokortikoidi ili NSAID imaju potencijal učinkovitog liječenja blagog do umjerenog DED-a. Razvoj formulacije s učinkom na stabilizaciju suznog filma, produljenim zadržavanjem na površini oka i produljenim oslobađanjem djelatne tvari omogućio bi smanjenje potrebne doze, odnosno bolji omjer koristi i rizika oftalmičkog lijeka. BeatDED projektom predviđen je strukturirani pristup razvoju NE s visokim kliničkim potencijalom za učinkovito liječenje DED-a. Strukturirani pristup osigurat će korištenje biorelevantnih in vitro alata razvijenih u sklopu projekta. Posebna pozornost posvetit će se izboru pomoćnih (bioaktivnih pomoćnih tvari fiziološki prisutnih u suznom filmu) i djelatnih tvari (glukokortikoidi i NSAID) s ciljem postizanja optimalne ravnoteže između svojstava formulacije i učinka formulacije na površini oka. Biorelevantni in vitro alati konstruirani na temelju ključnih fizioloških i anatomskih aspekata površine oka omogućit će razumijevanje procesa na međupovršini formulacije i površine oka.]]></summary_hr><summary_en><![CDATA[Dry eye disease (DED), a multifactorial disease of the ocular surface, is characterized by a loss of homeostasis of the tear film. DED affects millions of people worldwide, with a significant impact on the quality of life. The prevalence of DED increases with age. However, relatively high prevalence rates were reported in younger subjects due to enormous use of digital devices.O/w nanoemulsions (NE), ultrafine dispersions of oil in water, hold great potential for effective DED treatment. Over the past two decades, NEs are being developed as a strategy to enhance the eye-related bioavailability of immunomodulator cyclosporine A (CsA) following topical instillation. CsA is used in the treatment of severe DED; it has to be used for extended periods of time and its onset of action is postponed. Topical glucocorticoids or non-steroidal anti-inflammatory drugs (NSAIDs) short-term pretreatment could provide faster symptom relief than topical CsA alone. Moreover, topical glucocorticoids or NSAID have potential for effective treatment of mild-to-moderate DED. Development of formulations with tear film stabilizing effect, prolonged residence at ocular surface and sustained drug release would enable the reduction of required drug dose and consequent better benefit-risk balance of ophthalmic drug product. The BeatDED project envisions a structured approach to efficient development of NE with high clinical potential for the effective DED treatment guided by the developed biorelevant in vitro tools. Particular emphasis will be devoted to the selection of excipients (bioactive excipients normally present in the tear film) and drugs (glucocorticoids and NSAIDs) in order to achieve optimal balance between formulation properties and formulation effect on the ocular surface. The availability of biorelevant in vitro tools constructed on the basis of key physiological and anatomical aspects of ocular surface will enable understanding of processes at formulation/ocular surface interface.]]></summary_en></project><project>
<id>8788</id><title_hr><![CDATA[Istraživanje transkriptoma i sekretoma mezenhimskih matičnih stanica]]></title_hr><title_en><![CDATA[Revealing the adipose-derived mesenchymal stem cells transcriptome and secretome]]></title_en><user_id>2597</user_id><user_firstLast_name>Dragan Brnić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2019-04</proposal_call><code>UIP-2019-04-2178</code><acronim><![CDATA[SECRET]]></acronim><duration>01.03.2020 - 28.02.2025</duration><status>Završio</status><financ_value>265.440,31 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Veterinarska medicina, Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Veterinary medicine, Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Hrvatski veterinarski institut]]></institution_hr><institution_en><![CDATA[Croatian Veterinary Institute]]></institution_en><team_members_id>3051, 26950, 26783, 858411, 865510, 2543, </team_members_id><team_members_names><![CDATA[Dunja Vlahović, Petar Kostešić, Tomaž Mark Zorec, Marina Prišlin, Šimun Naletilić, Nina Krešić, ]]></team_members_names><keywords_hr><![CDATA[matične stanice, virus, molekularna biologija, regenerativna medicina, sekretom]]></keywords_hr><keywords_en><![CDATA[stem cells, virus, molecular biology, regenerative medicine, secretome]]></keywords_en><summary_hr><![CDATA[Potaknuta znatiželjom i željom za stvaranjem novih znanja u istraživanju matičnih stanica i virusa, interdisciplinarna skupina znanstvenika osmislila je SECRET projekt. Multidisciplinarnim pristupom i u inspirirajućoj atmosferi, SECRET stvara mrežu za razmjenu znanja i znanstveni rast. Okupljanjem oko nepoznanica vezanih uz osobitosti mezenhimskih matičnih stanica životinja i ljudi, njihovu gensku ekspresiju, sastav sekretoma tijekom in vitro kultivacije te prije i nakon infekcije, stvorit ćemo izvrsnu istraživačku grupu za predano istraživanje, suradnju i obrazovanje.	Istraživačke aktivnosti provodit će međunarodni tim od pet mladih i motiviranih istraživača Hrvatskog veterinarskog instituta, istraživač Veterinarskog fakulteta u Zagrebu, istraživač Instituta za mikrobiologiju i imunologiju Medicinskog fakulteta u Ljubljani i doktorand čije se zaposlenje planira u prvim mjesecima projekta. 	SECRET tim kombinira komplementarne vještine u različitim područjima istraživanja, uključujući molekularnu biologiju, virusologiju, biologiju stanica i matičnih stanica, patologiju i kirurgiju. S više od petnaest istraživačkih, šest edukacijskih aktivnosti, diseminaciju i umrežavanje, SECRET će pružiti izvanredne mogućnosti za razvoj karijera istraživača.	SECRET istražuje utjecaj uzgoja in vitro i infekcije na životinjske i ljudske mezenhimske matične stanice, moćan potencijalni lijek nazočan u ljudskom i životinjskom tijelu, istovremeno omogućavajući njihovu sveobuhvatnu komparativnu analizu. Integrirajući matične stanice u virusna istraživanja, SECRET pokazuje kako primijeniti inovativne pristupe u otkrivanju staničnog ponašanja i virusnih adaptacijskih mehanizama tijekom infekcije in vitro. 	Nova pitanja koja će se pojaviti tijekom projekta, postavit će temelje za buduću suradnju između istraživača. SECRET će osigurati doprinos regenerativnoj medicini i istraživanju matičnih stanica na europskoj razini, a u Hrvatskoj potaknuti značajan razvoj istraživanja matičnih stanica.]]></summary_hr><summary_en><![CDATA[Driven by curiosity and the desire to create new research avenues in stem cell and virus research, the SECRET project has been conceived by an interdisciplinary group of scientists. Through multidisciplinary approaches and an inspiring atmosphere, SECRET creates channels for knowledge exchange and scientific growth. Gathering around unanswered questions related to animal and human mesenchymal stem cell peculiarities in vitro, their gene expression, secretome composition prior to and following virus infection, will create a solid scientific network for dedicated research, collaboration and education. 	Research activities will be performed by an international team of five young and motivated researchers from the Croatian Veterinary Institute, a researcher from the Faculty of Veterinary Medicine, Zagreb, a researcher from Institute for Microbiology and Immunology, Faculty of Medicine, Ljubljana, and a to-be-employed doctoral student. The SECRET team combines complementary expertise and skills in various research areas, including molecular biology, virology, cell and stem cell biology, pathology and surgery. With over fifteen research activities, six education activities, dissemination and networking, SECRET will provide outstanding opportunities for the researchers’ career development.	The SECRET approach reveals the impact of cultivation on animal and human mesenchymal stem cells, a powerful potential therapeutic of the human and animal body, while also enabling their comparative analysis. 	Integrating stem cells into virus research SECRET teaches us how to take innovative approaches to reveal cellular behaviour and the viral adaptation struggle during the infection course in vitro. Scientific questions that will arise during project will lay the foundations for future collaborations.The SECRET project will ensure contributions to regenerative medicine and stem cell research at the European level, while in Croatia, it will foster the development of stem cell research.]]></summary_en></project><project>
<id>8792</id><title_hr><![CDATA[Modeliranje i simulacija u razvoju naprednih materijala]]></title_hr><title_en><![CDATA[Modelling and simulation in development of advanced materials]]></title_en><user_id>11229</user_id><user_firstLast_name>Marina Franulović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-3607</code><acronim><![CDATA[SIMMAT]]></acronim><duration>01.12.2019 - 15.06.2023</duration><status>Prekinut</status><financ_value>170.469,18 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, </scie_field_hr><scie_field_en>Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Tehnički fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Engineering]]></institution_en><team_members_id>13315, 12813, 26057, 26070, 26060, 865243, 25439, </team_members_id><team_members_names><![CDATA[Dražan Kozak, Kristina Marković, Matej Gljušćić, David Liović, Maja Dundović, Jasen Zenzerovic, Andrej Borić, ]]></team_members_names><keywords_hr><![CDATA[Ponašanje materijala, Eksperimentalno ispitivanje, Karakterizacija, Inverzno modeliranje, Simulacija]]></keywords_hr><keywords_en><![CDATA[Material behavior,  Experimental testing, Characterization, Inverse modeling, Simulation]]></keywords_en><summary_hr><![CDATA[Visoka razina tržišnog natjecanja danas postavlja putokaze za razvoj novih tehnologija u dizajnu strojarskih konstrukcija i predstavlja značajne izazove konstruktorima. Razvoj novih tehnologija proširuje mogućnosti optimizacije dizajna strojarskih konstrukcija te kao imperativ postavlja potrebu istraživanja ponašanja inovativnih materijala koji mogu ispuniti zahtjeve ovih tehnologija, te kriterije čvrstoće, krutosti i stabilnosti konstrukcija. Tijekom rada na projektu BIOMAT HRZZ-a koji je u završanoj fazi provedbe kontinuirano se vrši istraživanje mogućnosti primjene razvijene metodologije za modeliranje i simulaciju ponašanja biomaterijala na inovativne materijale. Posebnost u strukturi biomaterijala koja se promatra kao korelacija matrice i kolagenskih vlakana i njihova sličnost s kompozitnim strukturama, uz analizu potencijala za istraživanje inovativnih materijala usmjerava istraživanje prema kompozitnim strukturama. Razvoj novih tehnologija fokus projekta dodatno usmjerava prema istraživanju ponašanja ovih materijala dobivenih aditivnim tehnologijama. Planirano istraživanje predstavlja nastavak istraživanja na način da će se razvijena metodologija, efikasna kako za metalne materijale tako i biološke, prilagoditi i primijeniti na karakterizaciju, simulaciju te analizu ponašanja materijala dobivenih aditivnim tehnologijama. Stoga je osnovni cilj projekta utvrditi i provesti postupak modeliranja ponašanja kompozitnih materijala te dodatno titanijevih legura izrađenih aditivnim tehnologijama, validirati rezultate ispitivanjem fotoelastičnih materijala i preporučiti im primjenu. On će biti ostvaren kroz postupke eksperimentalnog istraživanja ponašanja materijala s fokusom na kompozitne materijale dobivene aditivnim tehnologijama uz testna ispitivanja titanijevih legura i fotoelastičnih materijala, matematičkog modeliranja uz optimizaciju identifikacije parametara materijala i simulaciju ponašanja materijala te validaciju rezultata fotoelastičnim ispitivanjem. ]]></summary_hr><summary_en><![CDATA[High level of competitiveness in the marketplace today increases importance of development of new technologies in mechanical structures design and represents challenges for constructors. The development of new technologies expands the possibilities of design optimization and raises the need for research of the innovative materials behavior which can meet the criteria of strength, rigidity and stability of construction. Within the framework of the project BIOMAT (CSF) the application of developed methodology for the characterization of biomaterials on innovative materials has been explored. Attention is given here to the biomaterials structure that is considered through the correlation of matrices and collagen fibers which appears similar to the composite structures. Consequently, with an analysis of the potential for the exploration of innovative materials, it directs the proposal of this research to the composite structures. The development of new technologies directs the research to the behavior of these materials produced using additive technologies. Thus the planned research is a continuation of previous research in a way that the developed methodology, efficient for both metallic and biomaterials, will be adapted and applied to the characterization, simulation and behavior analyses of innovative materials produced by additive technologies. Therefore, the main research goal is to determine and perform the characterization of composite materials produced by additive technologies, validate results by photoelasticimetry and recommend their application. It will be accomplished through:  experimental research of material behavior with focus on composite materials produced by additive technologies together with testing other materials (titanium alloys and photoelastic materials), mathematical modeling with optimization of material parameter identification and simulation of material behavior followed by validation of results by photoelastic testing.]]></summary_en></project><project>
<id>8794</id><title_hr><![CDATA[Istraživanje farmaceutskog ekspozoma slatkovodnih organizama - procjena rizika i prioritizacija]]></title_hr><title_en><![CDATA[Investigation of Pharmaceutical Exposome in Freshwater Organisms – Risk Assessment and Prioritization ]]></title_en><user_id>3673</user_id><user_firstLast_name>Senka Terzić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-9519</code><acronim><![CDATA[PHARMA-RISK]]></acronim><duration>01.02.2020 - 31.05.2024</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Interdisciplinarne prirodne znanosti, Kemija, </scie_field_hr><scie_field_en>Interdisciplinary natural sciences, Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>5188, 3674, 5179, 17738, 5158, 25897, 857298, 865850, </team_members_id><team_members_names><![CDATA[Ivan Senta, Marijan Ahel, Ivona Krizman Matasić, Jelena Dragojević, Iva Mikac, Petar Ujčić, Klaudija Ivanković, Karlo Jambrošić, ]]></team_members_names><keywords_hr><![CDATA[farmaceutski spojevi, slatkovodni organizmi, riba, bioakumulacija, metabolizam, sediment, voda, LC-MS, prioritizacija, procjena rizika, rijeka Sava]]></keywords_hr><keywords_en><![CDATA[pharmaceutical compounds, freshwater organisms, fish, bioaccumulation, metabolism,  sediment, water, LC-MS, proritization, risk assessment, Sava river]]></keywords_en><summary_hr><![CDATA[U posljednjih dvadeset godina farmaceutski spojevi su prepoznati kao važna kategorija zagađivala. Postojeća literatura pretežno je usmjerena na istraživanje pojavnosti i ponašanja farmaceutskih spojeva u abiotičkim matricama (npr. voda i sediment), dok su radovi o njihovim koncentracijama u vodenim organizmima još uvijek srazmjerno rijetki. Ta je situacija u suprotnosti s činjenicom da koncentracije farmaceutskih spojeva u vodi i sedimentu predstavljaju samo indirektnu mjeru njihove potencijalne toksičnosti, dok interne koncentracije tih tvari u vodenim organizmima određuju njihov stvarni potencijal za izazivanje štetnih posljedica. U skladu s tim, svrha ovog projekta je dobivanje novih uvida u bioakumulaciju i metaboličko ponašanje odabranih farmaceutskih spojeva u slatkovodnim organizmima, s ciljem unaprjeđenja procjene rizika izloženosti ovim zagađivalima i njihove znanstveno utemeljene prioritizacije. Plan projekta uključuje nekoliko međusobno povezanih koraka, od razvoja metoda preko provedbe laboratorijski kontroliranih modelnih pokusa do terenskih istraživanja. U prvoj fazi razvit će se i validirati visokospecifične multirezidualne analitičke metode za kvantitativno određivanje tragova odabranih farmaceutskih tvari u različitim tipovima okolišnih uzoraka (biota, sediment, voda). Te će metode biti upotrijebljene u pažljivo isplaniranim modelnim i terenskim istraživanjima usmjerenim na određivanje farmaceutskog ekspozoma slatkovodnih riba. Modelni bioakumulacijski pokusi provest će se na zebricama (Danio rerio), uz primjenu različitih uvjeta izlaganja farmaceutskim tvarima. Biokemijski učinci izlaganja odredit će se na temelju praćenja indukcije glavnih detoksifikacijskih enzima u sustavu citokroma P450. U završnoj fazi projekta provest će se terensko istraživanje u rijeci Savi. Dobiveni podatci bit će upotrijebljeni za procjenu okolišne relevantnosti rezultata modelnih pokusa te za prioritizaciju zagađivala farmaceutskog porijekla u savskom bazenu.]]></summary_hr><summary_en><![CDATA[The problem of environmental contamination with pharmaceutical chemicals has been widely recognised over the past 20 years. The current literature is strongly dominated by studies focused at assessing the exposure concentrations in abiotic matrices (e.g. water and sediments) while the reports on the pharmaceutical concentrations in aquatic organisms remain comparatively scarce. However, when considering the possible biological effects, the aqueous exposure concentrations are only an indirect measure of potential toxicity, while the key parameter which determines the substance&#39;s potential for adverse effects is its internal concentration in the organism. Consequently, this project aims to provide new insights into the bioaccumulation and metabolic behaviour of pharmaceuticals in freshwater organisms, which is essential for an improved risk assessment of these contaminants as well as for their scientifically-sound prioritization. The project plan includes several interconnected phases, from method development and laboratory-controlled exposure experiments to field studies. Highly specific analytical methods for quantitative multiresidue determination of trace levels of selected pharmaceutical compounds in different environmental matrices (biota, water, sediment) will be developed and validated. These methods will be applied in carefully planned model and field experiments focusing on the characterization of pharmaceutical exposome in freshwater fish. The model bioaccumulation experiments will be performed using zebrafish (Danio rerio) as target organism, while considering different exposure scenarios. The biochemical responses in fish will be followed by measuring induction of the major cytochrome P450 detoxification enzymes. As its final step, the project includes a ground-truthing study in the Sava River to assess the environmental relevance of the pharmaceutical exposome and to collect the critical data for prioritization of individual pharmaceutical contaminants.]]></summary_en></project><project>
<id>8796</id><title_hr><![CDATA[Djetinjstvo u protopovijesti na jugu Karpatske kotline]]></title_hr><title_en><![CDATA[Childhood in protohistory in the southern Carpathian Basin]]></title_en><user_id>3646</user_id><user_firstLast_name>Daria Ložnjak Dizdar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-2520</code><acronim><![CDATA[ARHKIDS]]></acronim><duration>01.02.2020 - 31.07.2024</duration><status>Završio</status><financ_value>76.448,34 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Arheologija, </scie_field_hr><scie_field_en>Archeology, </scie_field_en><institution_hr><![CDATA[Institut za arheologiju]]></institution_hr><institution_en><![CDATA[Institute of Archaeology in Zagreb]]></institution_en><team_members_id>7071, 6690, 26736, 19809, 25923, 12736, 26312, 26313, 21170, 5790, 13027, </team_members_id><team_members_names><![CDATA[Marko Dizdar, Ivan Drnić, Julie Dunne, Aleksandar Kapuran, Snježana Karavanić, Janja Mavrović Mokos, Katharina Rebay-Salisbury, Christophe Snoeck, Joanna Rachel Sofaer, Petra Rajić Šikanjić, Mateja Hulina, ]]></team_members_names><keywords_hr><![CDATA[prapovijest, južni dio Karpatske kotline, djetinjstvo, groblja, dob]]></keywords_hr><keywords_en><![CDATA[protohistory, southern Carpathian Basin, childhood, cemeteries, age]]></keywords_en><summary_hr><![CDATA[Projektom Djetinjstvo u protopovijesti na jugu Karpatske kotline (ARHKIDS) multidisplinarno će se proučavati djeca kao i materijalni tragovi vezani uz djecu pronađeni u grobljima, naseljima i ostalim arheološkim kontekstima u razdoblju od kasnoga brončanog do mlađega željeznog doba. Kombiniranim multidisciplinarnim pristupom, koji uključuje arheološku i antropološku analizu, zatim residio analize keramičkih posuda kao i analize stabilnih izotopa antropoloških uzoraka, istraživati će se biološka i socijalna dob djece, zatim svakodnevne aktivnosti kojima su se djeca bavila  – igra, usvajanje vještina, rad, odnos prema okolišu te rituali povezani s djecom. Dijakronim proučavanjem djece i djetinjstva kroz duži vremenski raspon od (1400. – 100. god. pr. Kr.) ukazalo bi se na položaj djece u različitim zajednicama i razdobljima te njihov doprinos prijenosu znanja i vještina u prošlim društvima. Proučavanje djece u zajednicama koje su živjele samoodrživim načinom života, povezane s prirodom i okolišem te ovisne o njima, mogu ukazati na pravce koje vrijednosti, vještine i znanja imaju trajniju vrijednost te su nužna za transfer društvenih i kulturalnih vrijednosti u budućnost.]]></summary_hr><summary_en><![CDATA[The project called Childhood in protohistory in the southern Carpathian Basin (ARHKIDS) will be a multidisciplinary study of children and child-related material traces found in graves, settlements, and other archaeological contexts in the period from the Late Bronze Age to the Early Iron Age. The combined multidisciplinary approach, which includes archaeological and anthropological analyses, residue analyses of ceramic vessels, and analyses of the stable isotopes of anthropological samples, will study the biological and social ages of children, the everyday activities undertaken by children – playing, adopting skills, working, interacting with the environment, and child-related rituals. The diachronic study of children and childhood over a long time period (1400 BC – 100 BC) will indicate the status of children in different communities and periods and their contribution to the transfer of knowledge and skills in past societies. The study of children from communities that were self-sustaining, connected with and dependent on nature and the environment, can show us which value, knowledge and skills have enduring value and are necessary for the transfer of social and cultural values into the future.]]></summary_en></project><project>
<id>8797</id><title_hr><![CDATA[Podpovršinski preferencijalni transportni procesi u poljoprivrednim padinskim tlima]]></title_hr><title_en><![CDATA[SUbsurface PREferential transport processes in agricultural HILLslope soils ]]></title_en><user_id>26843</user_id><user_firstLast_name>Lana Filipović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2019-04</proposal_call><code>UIP-2019-04-5409</code><acronim><![CDATA[SUPREHILL]]></acronim><duration>01.03.2020 - 29.02.2024</duration><status>Završio</status><financ_value>264.198,02 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, Interdisciplinarne biotehničke znanosti, </scie_field_hr><scie_field_en>Agriculture, Interdisciplinary biotechnical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Agronomski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Agriculture]]></institution_en><team_members_id>25784, 26703, 26774, 856048, 28579, 20438, </team_members_id><team_members_names><![CDATA[Zoran Kovač, Beck-Broichsitter Steffen, Groh Jannis, Jasmina Defterdarović, Vedran Krevh, Vilim Filipović, ]]></team_members_names><keywords_hr><![CDATA[hidropedologija, agrokemikalije, vadozna zona tla, lizimetri, preferencijalni tok, numerički modeli, opservatorij kritične zone]]></keywords_hr><keywords_en><![CDATA[hydropedology, agrochemicals, soil vadose zone, preferential flow, lysimeters, numerical models, critical zone observatory]]></keywords_en><summary_hr><![CDATA[Padinska poljoprivredna tla karakteriziraju značajne lokalne heterogenosti zbog kojih se javljaju procesi preferencijalnog toka vode u tlu te posljedično, neujednačeno vlaženje tla i nelinearni pronos agrokemikalija (gnojiva i pesticida). Primjer navedenih procesa, a koji se osobito negativno odražavaju na kvalitetu tla i vodnih resursa, su površinsko otjecanje, erozija, vertikalni pronos (procjeđivanje), podpovršinski preferencijalni tok te nelinearno ponašanje kemikalija; svi pod dodatnim utjecajem korijena biljke i evapotranspiracije. Stoga se kritična (nesaturirana) zona padinskih tala, smještena između površine tla i podzemne vode, smatra jednim od najsloženijih terestričkih sustava na Zemlji. Glavni cilj projekta SUPREHILL formiranje je istraživačke grupe i opservatorija kritične zone za praćenje procesa pronosa tvari na padinskim terenima kako bi se mogao kvantificirati podpovršinski preferencijalni tok vode i nelinearni pronos agrokemikalija. U istraživanju će se koristiti oprema za praćenje stanja na terenu u kombinaciji s laboratorijskim i numeričkim kvantifikacijskim metodama. Poljski će pokus biti opremljen senzorima za mjerenje vodne bilance, klimatskom stanicom te težinskim lizimetrima s neporušenim tlom u svrhu mjerenja izotopa vode, trasera, nitrata, otopljenog organskog ugljika te insekticida na bazi bakra u sustavu tlo-biljka-atmosfera. Interdisciplinarnim će se pristupom omogućiti kvantifikacija nelinearnih procesa u tlu, posebice toka vode i pronosa agrokemikalija. Detaljno praćenje procesa rezultirati će velikom bazom podataka koja će se koristiti za kalibraciju numeričkih modela te za razvoj novih postupaka modeliranja. Rezultati će se moći upotrijebiti za prilagodbu gospodarenja padinskim poljoprivrednim površinama, omogućavajući učinkovitije korištenje vode, hranjiva i pesticida. Također, cilj projekta jest uključivanje u inicijativu europske mreže lizimetara, što će osigurati buduće proširivanje istraživanja.]]></summary_hr><summary_en><![CDATA[Hillslope agricultural soils are characterized by local scale heterogeneities which can trigger preferential transport processes and result in uneven wetting of soil and a non-linear transport of agrochemicals (e.g., fertilizers, pesticides). Negative impact on soil and water resources may originate from these processes, e.g., from surface runoff, erosion, vertical leaching, subsurface preferential flow, nonlinear chemical behavior; also affected by crop uptake and evapotranspiration. Therefore, hillslope soil critical (vadose) zone, located between the soil surface and groundwater, is considered as one of the most complex terrestrial systems. The main objective of SUPREHILL project is to form a new research group and to set up critical zone observatory of transport processes in hillslope soils, aiming to quantify subsurface preferential flow and a nonlinear agrochemical transport. Research will be focused on local scale subsurface processes in soil and performed using field monitoring equipment combined with laboratory and numerical quantification methods. The experimental site will be equipped with a range of sensors for water balance measurements, climatic station and undisturbed weighable field lysimeters for measuring water isotopes, tracers, nitrates, dissolved organic carbon and copper-based insecticides in a soil-plant-atmosphere system. Interdisciplinary approach will ensure quantification of non-linear processes in hillslope soils, especially regarding the soil water flow and agrochemical dynamics. Precise monitoring will produce a large database, later used for numerical model calibration and development of novel modeling procedures. Results can be used for the adjustment of management practices at sloped agricultural sites, leading to more efficient use of water, nutrients and pesticides. Project objective is also to become a part of the Europe-wide lysimeter network initiative, allowing the expansion of the observatory focus through new research topics.]]></summary_en></project><project>
<id>8802</id><title_hr><![CDATA[(Epi)genomika i transkriptomika eukromatinskih satelitnih DNA u embriogenezi i razvoju]]></title_hr><title_en><![CDATA[(Epi)genomics and transcriptomics of euchromatic satellite DNAs in embryogenesis and development]]></title_en><user_id>5779</user_id><user_firstLast_name>Nevenka Meštrović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-4910</code><acronim><![CDATA[EpiTranSat]]></acronim><duration>15.02.2020 - 14.06.2024</duration><status>Završio</status><financ_value>132.404,27 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>332, 26554, 2781, 2776, 21387, 858407, </team_members_id><team_members_names><![CDATA[Brankica Mravinac, Gregor Bucher, Martina Pavlek, Tanja Vojvoda Zeljko, Evelin Despot Slade, Marin Volarić, ]]></team_members_names><keywords_hr><![CDATA[Tribolium castaneum, ponovljene sekvence, satelitne DNA, nanopor sekvenciranje, slaganje genoma, funkcija, transkripcija, modulacija gena]]></keywords_hr><keywords_en><![CDATA[Tribolium castaneum, repetitive sequences, satellite DNA, nanopore sequencing, genome assembly, function, transcription, genes modulation]]></keywords_en><summary_hr><![CDATA[Satelitne DNA (satDNAs) su visoko zastupljene, uzastopno ponovljene, nekodirajuće DNA, uglavnom smještene u (peri)centromernom heterochromatinu koje imaju ključnu ulogu u centromernoj funkciji. Postoje dokazi da su ta područja aktivno transkribirana, a transkripti su uključeni u formiranje heterohromatina, stresu i malignoj transformaciji. Novije studije također pokazuju postojanje različitih satDNA i u eukromatinu mnogih vrsta, ali podaci o njihovoj biološkoj ulozi u potpunosti nedostaju. Naša prethodna studija na modelnom organizmu, kukca Tribolium castaneum pokazala je postojanje devet vrlo zastupljenih satDNA (Cast1-Cast9) koji se nalaze isključivo u eukromatinskim regijama. Iako su satDNA, Cast1-Cas9, nisko zastupljene u sekvenciranom referentnom genomu vrste T. castaneum, kvantitativna analiza otkrila je da ove satDNA predstavljaju značajan udio, čak 5% genoma. Naši neobjavljeni rezultati ukazuju na transkripcijski potencijal i epigenetski status ovih satDNA koji govore u prilog njihovoj &#39;&#39;eukromatičnoj&#39;&#39; prirodi. Njihova zastupljenost u genomu, transkripcijski potencijal i moguća distribucija u blizini gena čine eukromatinske satDNA privlačnim za istraživanje. Stoga, da bismo stekli uvid u evolucijske trendove i biološku važnost eukromatinskih satDNA kod vrste T. castaneum, dva glavna cilja projekta biti će: 1) otkriti evolucijsku dinamiku eukromatinskih satDNA te otkriti gene u blizini nizova satDNA, što ćemo postići sekvenciranjem genoma dugim očitanjima nanopora i slaganjem Cast1-Cast9 u referentni genom i 2) utvrđivanje njihove funkcionalna uloge, istraživanjem transkripcijskijskog potencijala, epigenetske regulacije i utjecaja na ekspresiju gena u blizini tijekom embriogeneze i razvoja. Vrsta T. castaneum predstavlja izniman model za postizanje predloženih ciljeva, jer ima anotiran genom, jasno definirane razvojne faze, temeljito istraženu embriogenezu i razvojne faze mozga te tako omogućuje funkcionalnu procjenu transkriptoma eukromatinskih satDNA.]]></summary_hr><summary_en><![CDATA[Satellite DNAs (satDNAs) are abundant tandemly repeated, non-coding DNAs largely located in (peri)centromeric heterochromatin which have an essential role in centromere function. There are evidences that these regions are actively transcribed, and transcripts are engaged in heterochromatin formation, stress and malignant transformation. However, recent data revealed the existence of different satDNAs in euchromatin of many species but information on their biological role is completely missing. In the beetle model Tribolium castaneum we previously identified nine abundant satDNAs (Cast1-Cast9) located exclusively in euchromatic regions. Although Cast1-Cas9 satDNAs are strongly underrepresented in T. castaneum reference genome, quantitative analysis disclosed that these satDNAs comprise significant 5% of the genome. Our unpublished results indicate transcription potential and epigenetic status which speak in favour of their “euchromatic” nature. Genome abundance, their transcription potential and putative distribution in the vicinity of genes make euchromatic satDNAs attractive for investigation. To gain insight into evolutionary trends and the biological relevance of euchromatic satDNAs in T. castaneum two main goals will be addressed: 1) to discover the evolutionary dynamics of euchromatic satDNAs and detect genes in the vicinity of satDNA arrays, we will sequence the genome using a long read nanopore approach and Cast1-Cast9 will be assembled in the reference genome, and 2) to reveal their functional role, we will investigate their transcription potential, epigenetic regulation and possible impact on expression of genes in the vicinity during embryogenesis and development. T. castaneum represents an excellent model to achieve the proposed aims because it has annotated genome, clearly defined developmental stages, thoroughly explored embryogenesis and brain development which enable functional evaluation of the euchromatic satDNA transcriptome.]]></summary_en></project><project>
<id>8806</id><title_hr><![CDATA[Kliničko i eksperimentalno istraživanje laserski aktiviranog fotoakustičnog strujanja i fotoaktivirane dezinfekcije u endodontskom liječenju]]></title_hr><title_en><![CDATA[Clinical and experimental investigation of laser activated photoacoustic streaming and photoactivated disinfection in endodontic treatment]]></title_en><user_id>11262</user_id><user_firstLast_name>Ivona Bago </user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2019-04</proposal_call><code>UIP-2019-04-5303</code><acronim><![CDATA[LASERENDO]]></acronim><duration>01.01.2020 - 31.12.2024</duration><status>Završio</status><financ_value>213.401,15 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Dentalna medicina, Temeljne medicinske znanosti, Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Dental medicine, Basic Medical Sciences, Clinical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Stomatološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Dentistry]]></institution_en><team_members_id>6958, 19657, 25911, 25910, 23298, 23867, 23296, 23321, 855347, </team_members_id><team_members_names><![CDATA[Ivan Salarić, Ivana Savić Pavičin, Boris Pažin, Adriana Katunarić, Ivana Vidović Zdrilić, Jelena Vidas, Anja Sesar, Damir Šnjarić, Gabrijela Kapetanović Petričević, ]]></team_members_names><keywords_hr><![CDATA[endodoncija, infekcija, laser, ispiranje, fotoaktivirana dezinfekcija, bakterije ]]></keywords_hr><keywords_en><![CDATA[endodontics, infection, laser, irrigation, photo activated disinfection, bacteria]]></keywords_en><summary_hr><![CDATA[Glavni problem dosadašnjih protokola ispiranja korijenskih kanala je neturbulentna dinamika irigansa unutar kanala, što spriječava njegovo prodiranje u nedostupne dijelove endodontskog prostora. Rezultat je zaostajanje inficiranog organskog i anorganskog materijala i veći rizik neuspjeha endodontskog liječenja. Svrha ovog projekta je ispitati učinkovitost najnovijih protokola čišćenja kanalnog sustava zuba temeljenih na laserskoj tehnologiji. SWEEPS (engl. Shock Wave Enhanced Emission Photoacoustic Streaming) je tehnika laserski aktiviranog ispiranja koja se temelji na prijenosu energije Er:YAG lasera unutar irigansa uz stvaranje fotoakustičnih i fotomehaničkih kavitacija. Fotoaktivirana dezinfekcija (engl. photoactivated disinfection, PAD) je kemijska dezinfekcija koja se temelji na interakciji laserske zrake niske energije i netoksičnog fotosenzitivnog sredstva. U prvom dijelu istraživanja definirat će se mogućnost primjene SWEEPS tehnike za: uklanjanju vitalnog pulpnog tkiva, anorganskog materijala i bakterijskog biofilma iz endodontskog prostora zuba. U drugom dijelu projekta ispitat će se utjecaj SWEEPS tehnike ispiranja u kombinaciji s različitim irigansima na kemijska svojstva dentina. U trećem dijelu projekta ispitati će se klinički doprinos SWEEPS-a u eradikaciji endodontske infekcije kod pacijenata s pertistirajućom periapikalnom upalom. Ispitat će se i klinički doprinos PAD-e u cijeljenju perzistirajućeg periapikalnog procesa kod pacijenata koji zahtijevaju reviziju. Orginalnost predloženog projekta je u sveobuhvatnom interdisciplinarnom istraživanju najnovije tehnologije laserski aktiviranog ispiranja i fotoaktivirane dezinfekcije kojim će se razjasniti uloga SWEEPS-a u svim aspektima čišćenja endodontskog prostora zuba i njezin klinički doprinos standardnim protokolima endodontskog liječenja zuba. Rezultati istraživanja otvorit će nove mogućnosti uključivanja laserske tehnologije u standardne protokole endodontskog liječenja.]]></summary_hr><summary_en><![CDATA[The aim of modern root canal treatment is to remove intracanal infection and prevent reinfection. The main limitation of conventional irrigation protocols is inadequate dynamics of an irrigant inside the root canal, which prevents its penetration in inaccessible parts of endodontic space. The result is lagging of infected organic and inorganic material, which increases the risk of root canal treatment failure. The aim of this project is to evaluate the efficacy of the newest cleaning protocols based on laser technology. SWEEPS (Shock Wave Enhanced Emission Photoacoustic Streaming) is a laser activated irrigation technique which is based on the transmission of Er.YAG laser energy in irrigant inside the root canal with the creation of photoacoustic and photomechanical cavitations. Photoactivated irrigation (PAD) is chemical disinfection based on the interaction of low level laser energy and nontoxic photosensitive agent. In the first part of the study, the possibility of using SWEEPS technique will be defined for: removal of vital pulp tissue, inorganic material and bacterial biofilm from the endodontic space. In the second part, the influence of the SWEEPS irrigation technique in combination with various irigants on chemical properties of dentine will be examined. The third part of the project will examine the clinical contribution of the SWEEPS technique in eradication of endodontic infection in patients with perisistent periapical lesion. Also, the clinical contribution of the PAD in healing of persistent periapical lesion will be evaluated in group of patients requiring re-treatment. The originality of the proposed project is in interdisciplinary research of the latest laser activated irrigation protocols in order to clarify the role of the SWEEPS in all aspects of cleaning and its clinical contribution to standard root canal treatment. The research results will open new possibilities for incorporating laser technology into standard endodontic treatment.]]></summary_en></project><project>
<id>8814</id><title_hr><![CDATA[Jadranska maritimna hodočašća u lokalnom, nacionalnom i transnacionalnom kontekstu ]]></title_hr><title_en><![CDATA[Adriatic Maritime Pilgrimages in Local, National and Transnational Context ]]></title_en><user_id>22625</user_id><user_firstLast_name>Mario  Katić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2019-04</proposal_call><code>UIP-2019-04-8226</code><acronim><![CDATA[PILGRIMAR]]></acronim><duration>01.01.2020 - 31.12.2024</duration><status>Završio</status><financ_value>130.912,08 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Etnologija i antropologija, Povijest, </scie_field_hr><scie_field_en>Ethnology and anthropology, History, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zadru]]></institution_hr><institution_en><![CDATA[University of Zadar]]></institution_en><team_members_id>22670, 22671, 26834, 22562, 23328, 861526, 855443, </team_members_id><team_members_names><![CDATA[Mirela Hrovatin, Karmen Turčinov, Ante Blaće, Tomislav Klarin, Trpimir Vedriš, Petra Valovičić, Adriana Branka Pojatina, ]]></team_members_names><keywords_hr><![CDATA[hodočašće, Jadran, maritimni način života, turizam, baština, identitet, utjelovljeno iskustvo ]]></keywords_hr><keywords_en><![CDATA[pilgrimage, Adriatic, maritime way of life, tourism, heritage, identity, embodied experience]]></keywords_en><summary_hr><![CDATA[Uzimajući odabrana marijanska svetišta jadranskoga prostora kao arhetipska, maritimna hodočašća definiramo kao godišnje rituale štovanja lokalnih svetaca koja uključuju translokaciju svetoga objekta, ljudi, ili i jednoga i drugoga preko mora kao dio ritualne strukture. Naša je pretpostavka da su maritimna hodočašća postala „sidra“ za lokalne zajednice zbližavajući izmještene članove zajednice i održavajući transnacionalne veze. Štoviše, s razvojem turizma, maritimna hodočašća se ponovno „stvaraju“ te postaju važan ili glavni pokretač lokalne turističke ponude. Naša je hipoteza da su ovi različiti interesi oblikovani i potaknuti globalizacijskim procesima i da su lokalne hodočasničke prakse usmjerene više prema sekularnim manifestacijama koje rezultiraju procesom stvaranje baštine. Jedna od ideja ovoga interdisciplinarnog projekta je skupiti lokalno znanje pomoću etnografije kao osnovne metodologije, interpretirati mjesta unutar njihova povijesnoga konteksta nastanka pomoću novih spoznaja na temelju arhivskoga rada, kontekstualizirati ih pomoću GIS metodologije promatrajući ove religijske i kulturne prakse unutar njihova, vrlo važnoga, geografskoga konteksta morskoga krajolika i otoka. Te provesti analizu utjecaja turizma koja će se temeljiti na anketnom ispitivanju te organiziranju fokus grupa. Na temelju svega navedenoga, istraživačka skupina će proizvesti studiju koja će pokazati smjer održivoga razvoja maritimnih hodočašća na odabranim lokacijama kako bi lokalne zajednice imale koristi od maritimnih hodočašća kao resursa u održavanju zajednice, a s druge strane, zadržale utjecaj turizma u realnim okvirima i spriječile trajno devastiranje ovih mjesta i praksi. Cilj je i omogućiti bolje razumijevanje oblikovanja i prihvaćanja religijskih praksi unutar specifičnoga povijesnoga i geografskoga konteksta. Te na kraju, definirati temeljne karakteristike maritimnih hodočašća i uspostaviti referentnu točku za buduća istraživanja maritimnih hodočašća.  ]]></summary_hr><summary_en><![CDATA[With the Adriatic maritime pilgrimages serving as an archetype, we define maritime pilgrimages as those particular annual rites of veneration that include the translocation of sacred objects, people or both over water (including symbolical enactment) as a part of the ritual structure. Our hypothesis is that maritime pilgrimages have become anchors for local communities bringing together displaced members of the community and sustaining transnational ties. Moreover, with the development of tourism, maritime pilgrimages may have also been reinvented as one more, or in some cases the main, local tourist attraction. This study hypothesizes that these diverse interests may have been encouraged by globalization and that local pilgrimage practices may have evolved toward more secular and popular manifestations directed to “heritagization”. One of the ideas of this project is to gather local knowledge form the native point of view based on ethnographic research, frame it within historical background and new archival sources, contextualize with GIS methodology trying to observe these religious and cultural practices within their, very important, geographical context of the seascape and island, conduct a tourism study that will be produced based on a survey research and the organization of the focus groups. Following that, the project participants will produce a study that should indicate a sustainable development of these locations and practices in order to enable local community to benefit from maritime pilgrimage as a resource for keeping the community alive, but on the other hand, keeping the tourism impact on realistic levels in order not to irretrievable destroy these locations and practices. Provide a better understanding of the formation and adoption of religious practices within very specific historical and geographical context. And, define the main characteristics of maritime pilgrimages and establish a point of reference for future maritime pilgrimage research.]]></summary_en></project><project>
<id>8827</id><title_hr><![CDATA[Engleske riječi u hrvatskome jeziku: Identifikacija, afektivno-semantičko normiranje i ispitivanje kognitivne obrade bihevioralnim i neuroznanstvenim metodama]]></title_hr><title_en><![CDATA[English words in Croatian: Identification, affective-semantic norming and investigation into cognitive processing via behavioural and neuroscientific methods]]></title_en><user_id>25806</user_id><user_firstLast_name>Irena Bogunović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2019-04</proposal_call><code>UIP-2019-04-1576</code><acronim><![CDATA[ENGRI]]></acronim><duration>28.02.2020 - 27.02.2025</duration><status>Završio</status><financ_value>145.411,11 eur</financ_value><scie_area_hr>Interdiciplinarne znanosti, Humanističke znanosti, Tehničke znanosti, Društvene znanosti, </scie_area_hr><scie_area_en>Interdisciplinary scientific area, Humanities, Technological sciences, Social sciences, </scie_area_en><scie_field_hr>Interdisciplinarne humanističke znanosti, Računarstvo, Psihologija, Filologija, Kognitivna znanost, </scie_field_hr><scie_field_en>Interdisciplinary humanities, Computer sciences, Psychology, Philology, Cognitive science, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Pomorski fakultet ]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Maritime Studies]]></institution_en><team_members_id>26877, 4073, 26298, 26147, 26179, </team_members_id><team_members_names><![CDATA[Bojana Ćoso, Mirjana Borucinsky, Jasmina Jelčić Čolakovac, Mario Kučić, Eva Pavlinušić Vilus, ]]></team_members_names><keywords_hr><![CDATA[engleske riječi, hrvatski jezik, obrada prirodnog jezika,  jezična obrada, dvojezičnost ]]></keywords_hr><keywords_en><![CDATA[English words, Croatian language, natural language processing, language processing, bilingualism]]></keywords_en><summary_hr><![CDATA[Dosadašnja istraživanja u Hrvatskoj pristupala su engleskom kao globalnom i/ili stranom, te drugom jeziku. Novije spoznaje upućuju na to da se može govoriti o engleskom kao drugom jeziku, stoga će se ovo istraživanje smjestiti u teorijske okvire dvojezične obrade jezika. Modeli dvojezične leksičke obrade učenje riječi drugog jezika vide kao učenje/usvajanje novih formi za već postojeće koncepte, no engleske se riječi često koriste za nove pojmove za koje jezik primaoc nema odgovarajuću riječ. To ih čini posebno zanimljivima s neurokognitivnog aspekta, a podaci o njihovoj kognitivnoj obradi gotovo da ne postoje. U istraživanjima leksičke obrade učestalost riječi prepoznata je kao najjači utjecajni faktor, a uz učestalost važna su i afektivno-semantička obilježja, poput emocionalnosti riječi. No, podaci o učestalosti i afektivno-semantičkim obilježjima engleskih riječi u hrvatskome ne postoje. Stoga je neophodno izraditi bazu  engleskih riječi u hrvatskome s frekvencijama i hrvatskim istovrijednicama, za što će se koristiti metode obrade prirodnog jezika, kao i bazu njihovih afektivno-semantičkih normi. Rezultat prve dvije faze bit će dvije javno dostupne baze. Za potrebe eksperimentalnog dijela istraživanja, planira se uspostaviti laboratorij za psiholingvistička istraživanja s potrebnom opremom. Ispitivanje kognitivne obrade započet će bihevioralnim pristupom u kojem će se za ispitivanje leksičkog pristupa koristiti metoda pripremljenosti u kombinaciji sa zadatkom leksičke odluke, dok će se u drugom dijelu detektirati neurokognitivni obrasci prilikom obrade neprilagođenih engleskih riječi na leksičkoj i sintaktičkoj razini metodom evociranih potencijala. U završnoj fazi slijedi nadogradnja baze engleskih riječi s frekvencijama i hrvatskim istovrijednicama, što će omogućiti uvid u priljev takvih riječi u hrvatski jezik te eventualne promjene u učestalosti tijekom razdoblja od pet godina.]]></summary_hr><summary_en><![CDATA[In Croatian research, English has been treated either as a global and/or foreign language, or as a second language (L2). Resent research has given rise to the notion of English as L2. Thus, it seems appropriate to place this study within the theoretical frame of bilingual language processing. According to models of bilingual lexical processing, learning L2 words in most cases involves learning/acquisition of novel forms for already existing concepts. However, unadapted English words are often used for novel concepts for which the recipient language has yet to establish an adequate lexical item, which makes them especially interesting from a neurocognitive perspective.  Still, there is very little data on the lexical processing of these words. One reason might be a lack of data necessary for obtaining valid results. Research has recognized the importance of word frequency as well as affective-semantic properties of words as influential factors in word recognition. Therefore, the first two project stages are aimed at developing a database of English words in Croatian with frequencies and Croatian equivalents via natural language processing methods, as well as an affective and semantic normed database of English words, which will both be publicly available. To enable the research group to conduct the experimental part of the research, establishment of a laboratory for psycholinguistic research is planned. The first part of experimental investigation will explore cross-linguistic priming effect in Croatian-English bilinguals with different levels of L2 proficiency, while the second part will focus on neurocognitive patterns during cognitive processing of unadapted English words on lexical and syntactic level. Finally, the database of English words with frequencies will be updated, which will enable an insight into the diachronous aspect of the intake of English words into Croatian language.]]></summary_en></project><project>
<id>8828</id><title_hr><![CDATA[Nova bioanalitička rješenja za personalizaciju terapije raka dojke]]></title_hr><title_en><![CDATA[Novel bioanalytical solutions in personalized breast cancer treatment]]></title_en><user_id>13100</user_id><user_firstLast_name>Miranda Sertić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2019-04</proposal_call><code>UIP-2019-04-8461</code><acronim><![CDATA[OncoBioAnalytics]]></acronim><duration>01.03.2020 - 31.05.2025</duration><status>Završio</status><financ_value>250.580,66 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Farmacija, </scie_field_hr><scie_field_en>Pharmaceutical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Farmaceutsko-biokemijski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Pharmacy and Biochemistry]]></institution_en><team_members_id>26603, 4758, 26562, 855971, 865246, 865563, 865564, 865567, 869877, </team_members_id><team_members_names><![CDATA[Slaven Crnkovic, Hrvoje Rimac, Tajana Silovski, Lu Turković , Zvonimir Mlinarić, Josipa Božić, Matea Baković, Maja Ortner Hadžiabdić, Kristian Morić-Španić, ]]></team_members_names><keywords_hr><![CDATA[karcinom dojke, terapijsko praćenje lijeka, farmakokinetika, tekućinska kromatografija spregnuta s masenom spektrometrijom, kapilarna elektroforeza]]></keywords_hr><keywords_en><![CDATA[breast cancer, therapeutic drug monitoring, pharmacokinetics, liquid chromatography coupled to mass spectrometry, capillary electrophoresis]]></keywords_en><summary_hr><![CDATA[Rak dojke je najčešći zloćudni tumor u žena, od kojeg će oboljeti svaka osma žena. Gotovo 80% slučajeva raka dojke pozitivno je na hormonske receptore (HR+) i liječi se endokrinom terapijom. Nedavno je uvedena kombinacija endokrine (inhibitori aromataze anastrozol ili letrozol; antiestrogen fulvestrant) i ciljane terapije (inhibitori CDK4/6 palbociclib i ribociclib) za liječenje metastatskog raka dojke podtipa HR+, HER2- (receptor humanog epidermalnog faktora rasta 2).Kako bi se postigli bolji ishodi terapije i smanjile neželjene nuspojave, potreban je personalizirani pristup liječenju u svakodnevnoj kliničkoj praksi, čemu mogu značajno pridonijeti pouzdane i točne analitičke metode za terapijsko praćenje (TDM) onkoloških lijekova.Cilj ovog istraživanja je predložiti nove, osjetljive i selektivne bioanalitičke metode koji će poslužiti kao platforma za personalizirani pristup liječenju raka dojke. Naglasak će biti na novoodobrenim lijekovima, palbociklibu i ribociklibu, koji se primjenjuju zajedno s inhibitorima aromataze ili s fulvestrantom. Također će se provesti farmakokinetička i metabolička ispitivanja.Predložene nove analitičke metode koristit će se za praćenje koncentracije odabranih lijekova u plazmi. Bit će razvijene sofisticirane metode tekućinske kromatografije povezane s masenom spektrometrijom (HPLC-MS). Kao alternativa skupoj i složenoj HPLC-MS tehnici bit će razvijena robustna i potpuno automatizirana tehnika kapilarne elektroforeze (CE). CE ima veliki potencijal za primjenu u kliničkoj praksi zbog jednostavnosti i automatiziranosti, nakon uspostave validiranih protokola. Rezultati istraživanja će omogućiti optimalno terapijsko doziranje i povećati učinkovitost terapije, izbjegavajući toksičnost, nuspojave ovisne o koncentraciji ili izostanak željenog terapijskog učinka. Stoga će ovaj projekt doprinijeti implementaciji TDM-a za ciljanu terapiju raka dojke u sklopu standardne zdravstvene zaštite.]]></summary_hr><summary_en><![CDATA[Breast cancer is the most common malignant tumor in women with a one in eight prevalence.  Almost 80% of breast cancers are hormone receptor positive (HR+) and treated with endocrine therapy. Recently, a combination of endocrine (aromatase inhibitors anastrozole or letrozole; antiestrogen fulvestrant) and targeted therapy (CDK4/6 inhibitors palbociclib and ribociclib) has been introduced for the treatment of metastatic breast cancer subtype HR+, HER2- (human epidermal growth factor receptor 2). To achieve better therapy outcomes and reduce adverse drug events, a personalized approach to breast cancer treatment in routine clinical practice is needed. Reliable and accurate analytical methods for therapeutic drug monitoring (TDM) of oncology drugs can significantly contribute to this goal. The aim of this study is to propose new, reliable, sensitive and selective bioanalytical tools that will serve as a platform for a personalized approach to breast cancer treatment. Emphasis will be given to newly approved palbociclib and ribociclib, which are co-administered with aromatase inhibitors or fulvestrant. Pharmacokinetic and metabolic studies will also be conducted. Proposed new analytical methods will be used to monitor plasma concentrations of selected drugs. Highly sophisticated liquid chromatography coupled to mass spectrometry methods (HPLC-MS) will be developed. As an alternative to expensive and complex HPLC-MS technique, robust and fully automated capillary electrophoresis (CE) technique will be developed. CE has a great potential for translation to clinical setting due to minimal training and supervision required after establishing validated protocols. Research results will enable optimal therapeutic dosing and enhance the effectiveness of anticancer therapy, avoiding toxicity, concentration-dependent side-effects or therapeutic failure. This project will contribute to implementation of TDM for targeted breast cancer therapy as a part of standard health care.]]></summary_en></project><project>
<id>8831</id><title_hr><![CDATA[Identifikacija cirkulirajućih biomarkera neurološkog oporavka u bolesnika s ozljedom mozga]]></title_hr><title_en><![CDATA[Identification of circulating biomarkers for neuro-recovery  of brain-injured patients]]></title_en><user_id>6187</user_id><user_firstLast_name>Kristina Grabušić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-1511</code><acronim><![CDATA[CiMozak / CirBrain]]></acronim><duration>01.01.2020 - 31.12.2023</duration><status>Završio</status><financ_value>150.348,40 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Kliničke medicinske znanosti, Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Clinical sciences, Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Medicine]]></institution_en><team_members_id>25472, 25359, 3021, 26105, 26245, 26195, 26450, 25468, 856236, 855418, 856233, 855405, 855416, 855982, </team_members_id><team_members_names><![CDATA[Janja Kuharić, Vlatka Sotošek Tokmadžić, Natalia Kučić, Olga Shevchuk, Jelena Marinić, Ksenija Tulić, Simone Dal Zilio, Mladenka Malenica , Lada  kalagac Fabris, Lara Valenčić, Aleksandar Šuput, Maša Biberić, Siniša Zrna, Vedrana Krušić, ]]></team_members_names><keywords_hr><![CDATA[ozljeda mozga, neurološki oporavak, biomarkeri, cerebrospinalna tekućina, izvanstanične vezikule]]></keywords_hr><keywords_en><![CDATA[brain injury,  neurorecovery, biomarkers, cerebrospinal fluid, extracellular vesicles]]></keywords_en><summary_hr><![CDATA[Projektni prijedlog CiMozak usmjeren je na identifikaciju biomarkera neurološkog oporavka u bolesnika s teškom traumatskom ozljedom mozga. Ozljeda nastaje djelovanjem fizičke sile na glavu i dovodi do kome s potencijalnim smrtonosnim ishodom. Unatoč težini ozljede, moguć je potpuni neurološki oporavak. Međutim, nije poznato kada započinje oporavak mozga i koliko na njega utječu terapijske intervencije, jer nedostaje znanje o biomarkerima neurološkog oporavka.Glavni cilj je omogućiti praćenje oporavka mozga pomoću biomarkera u tjelesnim tekućinama. CiMozak ima snažno uporište u najnovijim ispitivanjima na životinjama koja pokazuju da odrasli mozak mijenja razine neuroregeneracijskih signala u cerebrospinalnoj tekućini (CSF). Nadalje, naši objavljeni i preliminarni rezultati analiza ljudskog CSF-a nakon ozljede mozga opisuju ranu indukciju: i) izvanstaničnih vezikula (IV-a), membranom obavijenih čestica koje se izlučuju iz stanica i prenose proteine i nukleinske kiseline; ii) novih proteina povezanih s neuroregeneracijom. Na temelju opisanih rezultata, CiMozak ima za cilj odrediti precizniju kinetiku promjena sljedećih elemenata u CSF-u: 1) veličine i broja IV-a pomoću nanotehnologije TRPS; 2) morfologije i proteinskog sadržaja IV-a pomoću elektronske mikroskopije; 3) subpopulacija IV-a pomoću kromatografije; 4) razina proteina povezanih s neuroregeneracijom pomoću spektrometrije; 5) sadržaj mikroRNA pomoću lančane reakcije polimerazom RT-PCR. Biomarkeri koji će u 1. fazi CiMozak-a pokazati najviše razine u CSF-u, bit će analizirani u plazmi u sklopu 2. faze CiMozak-a.Očekuje se da će CiMozak donijeti nove spoznaje o identitetu i kinetici cirkulirajućih biomarkera neurološkog oporavka. Biomarkeri iz CSF-a i krvi mogli bi omogućiti neinvazivno praćenje neurološkog oporavka bolesnika ne samo nakon teške traumatske ozljede mozga već i drugih ozljeda i bolesti mozga. Time bi se također omogućilo određivanje utjecaja različitih terapijskih intervencija na oporavak mozga.]]></summary_hr><summary_en><![CDATA[The CirBrain proposal intends to identify biomarkers of neurorecovery in patients with severe traumatic brain injury (TBI). Severe TBI is an intracranial damage caused by the impact on the head leading to coma and possible fatal outcome. Despite the severity of injury, a complete neural recovery is possible. However, it is not known when brain recovery is initiated and how it might be affected by therapeutic interventions since knowledge about neurorecovery biomarkers is lacking.The major goal of CirBrain is to enable monitoring of brain recovery by biomarkers in body fluids. CirBrain is strongly supported by the latest studies in animals showing that the adult mammalian brain modifies levels of neuroregenerative signals in cerebrospinal fluid (CSF). Moreover, our published and preliminary post-TBI analyses of human CSF describe early induction of: i) extracellular vesicles (EVs), membrane-enveloped particles derived from cells and able to transport proteins and nucleic acids; ii) novel neuroregeneration-associated proteins. Based on these results, CirBrain aims to determine a more precise CSF kinetics of changes in: 1) EV size and number by tunable resistive puls sensing; 2) EV morphology and protein content by immunogold staining and electron microscopy; 3) EV subpopulations by size-exclusion chromatography followed by slot-blot immunoanalysis; 4) levels of neuroregeneration- associated proteins by targeted mass spectrometry; 5) microRNA content by real-time PCR. The biomarkers with the highest CSF levels detected in the first phase will be further analysed in plasma as part of the second CirBrain phase.CirBrain is expected to give new insights into identity and kinetics of circulating biomarkers for neurorecovery after TBI. Moreover, biomarkers based on CSF and blood, might enable non-invasive monitoring of neurorecovery not only in TBI, but also in diverse brain pathologies, providing evaluation of how different treatments affect brain recovery.]]></summary_en></project><project>
<id>8839</id><title_hr><![CDATA[Daljinsko praćenje erozije riprap zaštite od podlokavanja na velikim rijekama u stvarnom vremenu]]></title_hr><title_en><![CDATA[Remote Real-time Riprap Protection Erosion AssessmenT on large rivers]]></title_en><user_id>6250</user_id><user_firstLast_name>Gordon Gilja</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2019-04</proposal_call><code>UIP-2019-04-4046</code><acronim><![CDATA[R3PEAT]]></acronim><duration>13.12.2019 - 12.06.2025</duration><status>Završio</status><financ_value>260.358,35 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Građevinarstvo, Geodezija, Interdisciplinarne tehničke znanosti, </scie_field_hr><scie_field_en>Civil engineering, Geodesy, Interdisciplinary technological sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Građevinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Civil Engineering]]></institution_en><team_members_id>20384, 27112, 4086, 27209, 856175, 866747, </team_members_id><team_members_names><![CDATA[Kristina Potočki, Antonija Cikojević, Nikola Adžaga, Matej Varga, Martina Kovačević, Marko Šrajbek, ]]></team_members_names><keywords_hr><![CDATA[Zaštita od podlokavanja, urušavanje riprapa, fizički model, hibridno modeliranje, remote sensing]]></keywords_hr><keywords_en><![CDATA[Scour protection, riprap subsidence, physical model, hybrid modelling, daljinsko istraživanje]]></keywords_en><summary_hr><![CDATA[Mjerenje hidrauličkih parametara tijekom nailaska velikih voda neophodno je za razumijevanje morfodinamičkog razvoja korita u blizini građevina, no istovremeno je mjerenje opasno i otežano zbog velike snage toka vode u blizini građevina. Ovim projektom planira se razviti sustav za daljinsko praćenje erozije riprap zaštite od podlokavanja na velikim rijekama u stvarnom vremenu za vrijeme velikih voda, kojim bi se omogućilo mjerenje u uvjetima koji ograničavaju primjenu tradicionalnih metoda. U tu svrhu planira se razviti prototip plutače ScourBuoy opremljene senzorima za daljinsko mjerenje dubine korita i svog prostornog kretanja. U ovom projektu istraživanje utjecaja velikovodnih događaja na razvoj kaverni temelji se na pristupu hibridnog modeliranja – združenog eksperimentalnog ispitivanja na fizičkom modelu umanjenog mjerila i numeričkih simulacija u mjerilu prototipa. Oba modela će biti verificirana podacima prikupljenim ScourBuoyom za dokazivanje pouzdanosti zaključaka izvedenih na temelju podataka modela. Doprinos predloženog istraživanja u odnosu na aktualno stanje područja ogleda se u premještanju težišta istraživanja na mostove oko kojih je već izvedena riprap zaštita od podlokavanja – postojećih građevina čija je stabilnost i s njom povezana sigurnost nepoznanica u hidrauličkom okolišu pod utjecajem klimatskih promjena i s njima povezanih velikovodnih događaja. Pojedinačni istraživački ciljevi projekta su: (1) unaprijediti postojeće empirijske zavisnosti za određivanje ravnotežnih karakteristika kaverne eksperimentalnim ispitivanjem u laboratoriju (faza I) i numeričkim simulacijama (faza II), (2) istražiti zavisnosti turbulentnih karakteristika toka i vremenskog razvoja kaverne te (3) ispitati uvjete u kojima dolazi do početnog pomaka čestica u kaverni. Implementacijom rezultata istraživanja u sustave gospodarenja mostovima omogućava pravovremeno donošenje odluka o mjerama i radnjama potrebnim za osiguranje stabilnosti mosta tijekom nailaska velikih voda.]]></summary_hr><summary_en><![CDATA[Field surveys of hydraulic parameters during floods is essential in understanding morphodynamic evolution of the river channel, while dangerous and difficult at the same time for field surveys due to the increased flow power in vicinity of the structures. The aim of this research is to develop “ScourBuoy, a remote real-time buoy for remote sensing of scouring and its own displacement. Development and progression of scouring under high flow conditions plans to be investigated using hybrid modelling approach – coupled experimental investigations on scaled physical model and numerical model in prototype scale. Both models will be verified using ScourBuoy field data in order to demonstrate the reliability of conclusions based on model generated data. Contribution of proposed project to state of the art research is focus shift towards the bridges that have installed riprap protection around them – existing structures whose stability and associated safety is unknown in hydraulic environment influenced by climate change. Project research goals are: (1) improve existing empirical equations for equilibrium scour hole size through experimental investigations in laboratory flume (phase I) and numerical simulations (phase II), (2) investigate dependence of temporal scour hole development on turbulent flow characteristics (3) investigate turbulent conditions for incipient motion of sediment particles. Implementation of results in bridge management systems enables timely decision-making implemented in plan of action mandatory to secure bridge stability during extreme flooding events.]]></summary_en></project><project>
<id>8840</id><title_hr><![CDATA[Potencijalne terapijske biomolekule druge generacije probiotika]]></title_hr><title_en><![CDATA[Potential therapeutic biomolecules of next-generation probiotics]]></title_en><user_id>798</user_id><user_firstLast_name>Blaženka Kos</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-2237</code><acronim><![CDATA[PRO-BIO 2.0]]></acronim><duration>10.12.2019 - 09.12.2023</duration><status>Završio</status><financ_value>115.681,20 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Biotehnologija, Interdisciplinarne biotehničke znanosti, </scie_field_hr><scie_field_en>Biotechnology, Interdisciplinary biotechnical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Food Technology and Biotechnology]]></institution_en><team_members_id>799, 796, 797, 18967, 21384, 1011, 26420, 26422, 3005, 23410, 858323, 3319, </team_members_id><team_members_names><![CDATA[Jagoda Šušković, Jasna Novak, Andreja Leboš Pavunc, Martina Banić, Katarina Butorac, Ksenija Durgo, Paola Cescutti, Barbara Bellich, Ana  Savić Mlakar, Dyana Odeh, Nina Čuljak, Nada Oršolić, ]]></team_members_names><keywords_hr><![CDATA[biomolekule, egzopolisaharidi, intestinalna mikrobiota, mikrobiom, nanoinkapsulacija, probiotici, S-proteini]]></keywords_hr><keywords_en><![CDATA[biomolecules, exopolysaccharides, intestinal microbiota, microbiome, nanoencapsulation, probiotics, S-proteins]]></keywords_en><summary_hr><![CDATA[Najnovija istraživanja druge generacije probiotika usmjerena su na njihovu terapijsku primjenu kao „živih lijekova”, nazvanih od strane US FDA „živi bioterapijski pripravci“. Naime, promjene u sastavu crijevne mikrobiote su ustanovljene kod različitih metaboličkih poremećaja i bolesti, a ključnu ulogu u uspostavljanju ravnoteže crijevne mikrobiote imaju prvi dani života, pri čemu mikrobiota majčinog mlijeka značajno utječe na sastav crijevne mikrobiote dojenčeta. Stoga je glavni cilj istraživanja odabir i funkcionalna karakterizacija probiotičkih sojeva bakterija mliječne kiseline (BMK), izoliranih iz uzoraka majčinog mlijeka, a koje proizvode molekule s potencijalnim terapijskim djelovanjem, egzopolisaharide (EPS) i površinske S-proteine, što je svojstvo samo rijetkih sojeva BMK. Bit će provedena komparativna  analiza sekvencioniranih genoma odabranih sojeva BMK te izolacija, purifikacija i karakterizacija potencijalnih terapijskih biomolekula, primjenom LC/MS, MALDI-TOF i NMR analiza. Potencijal odabranih probiotičkih sojeva BMK, i njihovih specifičnih biomolekula, u adheziji, kolonizaciji, kompetitivnoj ekskluziji patogena, imunomodulaciji, regeneraciji sluznice crijeva i utjecaju na sastav mikrobiote u gastrointestinalnom traktu (GIT-u) će biti istražen na in vitro, ex vivo i in vivo eksperimentalnim modelima simuliranog GIT-a, Caco-2 crijevnih epitelnih stanica, primarne stanične kulture humanih kolonocita s izazvanim upalnim procesom i eksperimentalnih miševa kojima će biti izazvana upalna bolest crijeva. Okarakterizirani sojevi BMK i njihove izolirane i purificirane funkcionalne biomolekule s potencijalnim terapijskim djelovanjem, biti će proizvedeni kao nano- i mikro-inkapsulirani, liofilizacijom osušeni pripravci. Bit će provedeno optimiranje sastava protektivnih matriksa za inkapsulaciju u svrhu postizanja zaštitnog učinka tijekom proizvodnje i oralne primjene, te boljeg preživljavanja i probiotičke aktivnosti sojeva BMK na ciljnom mjestu djelovanja.]]></summary_hr><summary_en><![CDATA[The next generation probiotic investigations are focused on their therapeutic use as &#39;&#39;living drugs&#39;&#39;, which are entitled &#39;&#39;Live Biotherapeutic Products&#39;&#39; by US FDA. Namely, the altered intestinal microbiota composition has been associated with various metabolic disorders, and the establishing of the intestinal microbiota balance in the earliest days of life is crucial, since breast milk microbiota is significantly affecting the composition of the infant intestinal microbiota. Therefore, the aim of this research is selection and functional characterization of probiotic lactic acid bacteria (LAB), isolated from mother&#39;s milk, with a capacity to synthesize biomolecules with potential therapeutic activity, exopolysaccharides (EPS) and surface S-proteins, which are produced by sparse LAB strains. Besides comparative genome analysis of the selected LAB, purification and characterization of promising therapeutic biomolecules will be performed by LC/MS, MALDI-TOF and NMR analysis. The potential of selected and characterised LAB strains and their specific biomolecules in the adhesion, colonisation, competitive exclusion, immunomodulation, regeneration of intestinal barrier function and the impact of the intestinal microbiota composition will be investigated by in vitro, ex vivo and in vivo experimental models demonstrated through application of Caco-2 intestinal epithelial cells, human colonocytes in primary cell culture with induced inflammation and on experimental chemically induced murine models of inflammatory bowel disease. Well-characterized LAB strains and their isolated and purified functional biomolecules with potential therapeutic activity will be produced as nano- and micro-encapsulated, freeze-dried preparations. The composition of protective matrices for encapsulation will be optimised in order to achieve protective effect during production and oral delivery, and to improve survival and probiotic activity of LAB strains in situ.]]></summary_en></project><project>
<id>8842</id><title_hr><![CDATA[Utjecaj klimatskih promjena na bioraznolikost koralja - istraživanje slučaja masovnih ugibanja u Jadranskom moru]]></title_hr><title_en><![CDATA[Impact of climate change on coral biodiversity - research of mass mortality events in the Adriatic Sea]]></title_en><user_id>4351</user_id><user_firstLast_name>Petar Kružić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-3389</code><acronim><![CDATA[ADRICOR]]></acronim><duration>01.02.2020 - 31.07.2024</duration><status>Završio</status><financ_value>132.513,77 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, Interdisciplinarne prirodne znanosti, </scie_field_hr><scie_field_en>Biology, Interdisciplinary natural sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>26720, 19415, 26575, 26123, 26520, 26871, 858428, 865665, </team_members_id><team_members_names><![CDATA[David Stanković, Romana Gračan, Sven Horvatić, Ana Prohaska, Borut Mavrič, Lovrenc Lipej, Pavel Ankon, Andrea Čačković Čačković, ]]></team_members_names><keywords_hr><![CDATA[Klimatske promjene, koralji, bioraznolikost, ugroženost, Jadransko more]]></keywords_hr><keywords_en><![CDATA[Climate change, corals, biodiversity, endanger, Adriatic Sea]]></keywords_en><summary_hr><![CDATA[Znanstvenici i upravitelji zaštićenih područja prepoznali su hitnu potrebu za poboljšanim metodama i alatima koji će omogućiti učinkovitu prilagodbu mjera upravljanja u uvjetima klimatskih promjena. Predloženi projekt se polazi iz znanstvenog i terenskog iskustva prikupljenog tijekom procjene utjecaja masovnih ugibanja koralja u različitim područjima Jadranskog mora. Projekt je razvijen usredotočujući se na glavne vrste koralja koje žive u plitkim vodama (0-50 m) u istočnom dijelu Jadranskog mora. Međutim, dobiveni rezultati projekta se također mogu prilagoditi kako bi se procijenio utjecaj na druge vrste sesilnih vrsta podmorja. Glavni cilj projekta je postaviti očuvanje ispitanih populacija ugroženih koralja uz prikupljanje osnovnih informacija kako bi se procijenili učinci događaja masovnih ugibanja kada do njih dođe. Godišnja istraživanja na odabranim mjestima pružit će polazne vrijednosti za procjenu mogućeg negativnog učinaka. Cilj projekta nije zaustaviti utjecaj klimatskih promjena, već pomoći u razumijevanju kako dodatno smanjiti negativan antropogeni utjecaj na podmorja Jadrana. Cilj projekta je steći nove informacije o posljedicama globalnih klimatskih promjena na ekosustav mora, posebno u obalnom području. Projekt identificira i karakterizira negativne utjecaje na biološku raznolikost mora i razvija sposobnost predviđanja budućih promjena. Kako bi ostvarili zadane ciljeve, projekt predlaže multidisciplinarni pristup koji integrira različite razine biološke organizacije, od jedinki do populacija i zajednica, u određenom prostoru i vremenu. ]]></summary_hr><summary_en><![CDATA[Scientists and managers of natural resources have recognized an urgent need for improved methods and tools to enable effective adaptation of management measures in the face of climate change. The proposed protocol is based on scientific and field experience gathered during the assessment of mass mortality impact in different areas of the Adriatic Sea. The project has been developed focusing in main coral species dwelling in shallow waters (0-50 m) in the Eastern part of the Adriatic Sea. However, the project can be adapted to assess the impact on other macrobenthic species. The main goal of the project is to preserve the populations surveyed by collecting basic information to assess the effects of mass mortalities. Annual research at selected sites will provide initial values for assessing possible negative effects. The project&#39;s goal is not to stop the negative impact of climate change, but to help understand how to further reduce the negative anthropogenic impact on the Adriatic Sea. The objective of the project is to gain new information regarding the consequences of global climate change on marine ecosystems, particularly in coastal regions. The project identifies and characterizes negative impacts on marine biodiversity and develops methods and models for predicting future changes. To achieve these goals, the project proposes a multidisciplinary approach that integrates different levels of biological organization, from individuals to populations.]]></summary_en></project><project>
<id>8843</id><title_hr><![CDATA[Uloga krvno-moždane barijere, urođene imunosti i oligomerizacije tau proteina u patogenezi Alzheimerove bolesti]]></title_hr><title_en><![CDATA[Role of blood-brain barrier, innate immunity, and tau protein oligomerization in the pathogenesis of Alzheimer&#39;s disease]]></title_en><user_id>11124</user_id><user_firstLast_name>Goran Šimić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-3584</code><acronim><![CDATA[ALZ-BBB-INNATETAU]]></acronim><duration>15.01.2020 - 14.06.2024</duration><status>Završio</status><financ_value>199.084,14 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, Clinical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>215, 26549, 22652, 27314, 25387, 20884, 25455, 19042, 4936, 12685, 8532, 13330, 6698, 13342, 6442, 27331, 855795, </team_members_id><team_members_names><![CDATA[Ankica Sekovanić, Ena Španić, Lea Langer Horvat, Velimir Altabas, Klara Zubčić, Mirta Boban, Ana Mlinarić, Antonela Blažeković, Vesna Lukinović-Škudar, Danira Bažadona, Mirjana Babić Leko, Željka Vogrinc, Dražen Huić, Marina Boban, Martina Rinčić, SREĆKO BRANICA, Dina Franić, ]]></team_members_names><keywords_hr><![CDATA[Alzheimerova bolest, amiloid ß, astrociti, krvno-moždana barijera, cerebrospinalna tekućina, urođena imunost, mikroglija, monociti, tau proteini]]></keywords_hr><keywords_en><![CDATA[Alzheimer’s disease, amyloid ß, astrocytes, blood-brain barrier, cerebrospinal fluid, innate immunity, microglia, monocytes, tau proteins]]></keywords_en><summary_hr><![CDATA[Hipoteza amiloidne kaskade dobro objašnjava obiteljske slučajeve Alzheimerove bolesti (AD) s poznatim mutacijama, ali je nedostatna za razumijevanje nastanka sporadične AD s kasnim početkom koja čini više od 95% svih slučajeva AD. Genetička i eksperimentalna istraživanja ukazuju da bi disfunkcija mikroglije i povećana propusnost krvno-moždane barijere (BBB) mogli biti uzročni čimbenici za nastanak AD. Zato predlažemo detaljnu analizu tih manje istraženih aspekata bolesti jer mogu doprinijeti objašnjenju agregacije tau proteina i neurofibrilarne patologije koja najbolje korelira s kliničkim simptomima i napredovanjem bolesti. Naši su ciljevi: 1. ispitati odnose između kognicije zdravih kontrola (HC), ispitanika s blagim spoznajnim oštećenjem (MCI) i ispitanika s AD s biološkim biljezima urođene imunosti u krvi i likvoru; osim niza neuropsiholoških testova, MR analize kortikalne atrofije i slušnih evociranih potencijala, stanje kognicije ćemo procjenjivati testom skrivenog objekta pomoću vlastitog ALZENTIA® sustava; 2. odrediti propusnost BBB u HC, MCI, i AD ispitanika mjerenjem omjera albumina u likvoru i serumu te određivanjem razine lakog lanca neurofilamenata i S100B proteina, kao i 24 metala, metaloida i elementa u tragovima; 3. procijeniti stupanj neuroimunološke aktivacije u sve 3 skupine ispitanika putem mjerenja vrijednosti TNF?, IL-1ß, VILIP-1, YKL-40, sTREM2, MCP1, CCL3, CCL4 i eotaksina-3 u krvi i likvoru te vizualizacijom neuroinflamacije i M1 mikroglije u postmortalnim uzorcima mozga (C1q, CD11b, CD68, CX3CR1, HLA-DR, Iba1, TREM2) i analize integriteta (prikaz akvaporinskih AQP4 kanala i kolagena tipa IV) i funkcije (prikaz LRP1, VDRLR i RAGE receptora) BBB u HC i AD, kao i mozgovima Wistar štakora inokuliranih patološkim tau oligomerima; i 4. Konstruirati luminescentni reporter za praćenje oligomerizacije tau proteina čovjeka u živim stanicama kvasca, koje ćemo koristiti za ispitivanje učinka proteotoksičnog stresa i starenja na tau oligomerizaciju.]]></summary_hr><summary_en><![CDATA[The amyloid cascade hypothesis explains familial cases of Alzheimer’s disease (AD) with known mutations, but is insufficient to explain sporadic, late-onset AD that accounts for over 95% of all cases. Genetic and experimental studies have implicated microglial dysfunction and blood-brain barrier (BBB) disruption as causal factors for AD. We propose an in-depth analysis of these aspects of the disease that may contribute mechanistically to the development of tau protein aggregation and neurofibrillary lesions, which show the highest correlation with clinical symptoms and progression of AD. Our aims are: 1. To examine the relationships between cognitive status of healthy controls (HC), subjects with mild cognitive impairment (MCI) and AD subjects with blood and cerebrospinal fluid (CSF) markers of innate immune activation; a battery of neuropsychological tests, MRI analysis of cortical atrophy, auditory event-related potentials will be performed, and cognition assessed by the hidden-goal test using the ALZENTIA® system we developed; 2. To determine the BBB permeability in HC, MCI, and AD subjects by measuring CSF/blood albumin ratio and levels of neurofilament light chain and S100B proteins, as well as concentrations of 24 metal, metalloids, and trace elements; 3. To evaluate neuroimmune activation in the 3 groups through assessment of CSF and blood TNF?, IL-1ß, VILIP-1, YKL-40, sTREM2, MCP1, CCL3, CCL4, and eotaxin-3, and postmortem tissue markers of neuroinflammation and M1 microglial activation (C1q, CD11b, CD68, CX3CR1, HLA-DR, IBA1, TREM2) and through immunocytochemical analysis of BBB integrity (AQP4 channels, collagen type IV) and function (LRP1, VDRLR, and RAGE receptors) in HC and AD brains as well as in Wistar rats inoculated with pathological tau oligomers; and 4. To construct a luminescent reporter for monitoring human tau oligomerization in living yeast cells, which we will use to examine the effect of proteotoxic stress and aging on tau oligomerization.]]></summary_en></project><project>
<id>8844</id><title_hr><![CDATA[Hiperheurističko oblikovanje pravila raspoređivanja]]></title_hr><title_en><![CDATA[Hyperheuristic Design of Dispatching Rules]]></title_en><user_id>6984</user_id><user_firstLast_name>Domagoj Jakobović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-4333</code><acronim><![CDATA[HyDDRa]]></acronim><duration>01.01.2020 - 31.12.2023</duration><status>Završio</status><financ_value>96.887,65 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>26484, 26109, 26096, 24153, 864992, </team_members_id><team_members_names><![CDATA[Marko Čupić, Mateja Đumić, Rebeka Čorić, Marko Đurasević, Bruno Gašperov, ]]></team_members_names><keywords_hr><![CDATA[raspoređivanje, heuristički algoritmi, hiperheuristike, evolucijsko računarstvo, genetičko programiranje]]></keywords_hr><keywords_en><![CDATA[scheduling, heuristic algorithms, hyperheuristics, evolutionary computation, genetic programming]]></keywords_en><summary_hr><![CDATA[Raspoređivanje je proces u kojemu je određeni skup poslova (aktivnosti) potrebno dodijeliti ograničenom skupu strojeva (sredstava), s ciljem optimiranja korisnički definiranih kriterija i zahtjeva. Zbog svoje složenosti većina problema raspoređivanja ne može se riješiti egzaktno, već se za njihovo rješavanje koriste različiti heuristički i metaheuristički postupci. Posebice veliki problem predstavljaju dinamički problemi raspoređivanja, kod kojih informacije o problemu (dolazak poslova u sustav, trajanja izvođenja poslova, kvarovi strojeva), nisu poznate unaprijed, već postaju poznate tijekom rada sustava. Umjesto ručnog definiranja prilagođenih algoritama raspoređivanja za različite kombinacije oganičenja i kriterija, hiperheurističkim postupcima moguće je automatski oblikovati postupak raspoređivanja za zadani problem. Hiperheuristički postupci su optimizacijske metode koje ne pronalaze rješenje zadanog problema, već optimiraju postupak rješavanja problema; najpoznatiji primjeri hiperheuristika su genetičko programiranje i inačice evolucijskih algoritama.Ovaj je projekt usmjeren na primjene različitih hiperheurističkih metoda s ciljem izrade pravila raspoređivanja za dinamičke probleme raspoređivanja koje nisu iscrpno proučene u literaturi. U ovom projektnom prijedlogu fokus je stavljen na okruženje nesrodnih strojeva i njegove varijante. Projektni prijedlog obuhvaća nekoliko smjerova istraživanja kojima je cilj poboljšanje kvalitete hiperheuristika u oblikovanju pravila raspoređivanja. Također, jedan od ciljeva projekta je i proširenje ove paradigme na srodne optimizacijske probleme, kao što su raspoređivanje uz ograničenja sredstava te usmjeravanje vozila. Projektni tim posjeduje potrebno iskustvo u primjeni hiperheurističkih i optimizacijskih postupaka te objavljene preliminarne rezultate koji upućuju na isplativost daljnjeg istraživanja u opisanom području.]]></summary_hr><summary_en><![CDATA[Scheduling is a process in which a certain set of tasks (activities) need to be assigned to a limited set of machines (resources) to optimize user-defined criteria and requirements. Because of its complexity, most of the scheduling problems cannot be solved exactly, but different heuristic and metaheuristic procedures are used for their solution. A particularly big challenge is dynamic scheduling, where information about the problem (job release dates, processing time, machine failures) is not known in advance but becomes known during system operation. Instead of manually defining customized scheduling algorithms for different combinations of constraints and criteria, hyperheuristic procedures can automatically form the scheduling algorithm for a given problem. Hyperheuristic procedures are optimization methods that do not find the solution to the problem, but optimize the problem-solving algorithm; the most common examples of hyperheuristics are genetic programming and variants of evolutionary algorithms. This project focuses on the application of various hyperheuristic methods with the aim of developing dispatching rules for dynamic scheduling problems that have not been thoroughly studied in the literature. In this project proposal, the focus is placed on the unrelated machines scheduling environment and its variants. The project proposal encompasses several research directions aimed at improving the quality of hyperheuristics in automatic developing of the dispatching rules. Additionally, one of the project&#39;s goals is to extend this paradigm to related optimization problems, such as scheduling with resource constraints and vehicle routing. The project team possesses the necessary experience in applying hyperheuristics and optimization methods and has published preliminary results indicating the viability of further research in this area.]]></summary_en></project><project>
<id>8851</id><title_hr><![CDATA[Hibridno sušenje i valorizacija biljnog prehrambenog otpada i nusproizvoda]]></title_hr><title_en><![CDATA[Hybrid drying and valorisation of plant food waste and by-products]]></title_en><user_id>2702</user_id><user_firstLast_name>Mladen Brnčić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-9750</code><acronim><![CDATA[HYDRYBY]]></acronim><duration>01.01.2020 - 30.12.2024</duration><status>Završio</status><financ_value>128.077,51 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Prehrambena tehnologija, </scie_field_hr><scie_field_en>Food technology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Food Technology and Biotechnology]]></institution_en><team_members_id>13351, 448, 2663, 591, 12337, 21438, 19134, 19151, 20151, 19401, 11209, 26724, 858359, </team_members_id><team_members_names><![CDATA[Filip Dujmić, Suzana Rimac Brnčić, Sven Karlović, Marija  Badanjak Sabolović, Antonela Ninčević Grassino, Kristina Kljak, Jana Šic Žlabur, Sandra  Voća, Marko Škegro, Iva Čanak, Damir Semenski, Atanas G. Atanasov, Roko Marović, ]]></team_members_names><keywords_hr><![CDATA[Vakuum-kondukcijsko sušenje, mikrovalno-konvekcijsko sušenje, ultrazvuk, visoki hidrostatski tlakovi, karoteni, bundeva, avokado, izoterme sorpcije]]></keywords_hr><keywords_en><![CDATA[Vacuum-conductive drying, microwave-convective drying, ultrasound, high hydrostatic pressures, carotenes, pumpkin, avocado, sorption isotherms]]></keywords_en><summary_hr><![CDATA[Sušenje je jedan od najstarijih procesa konzerviranja hrane. Dostupne su brojne tehnike sušenja različitih sirovina kako bi se dobili proizvodi visoke kvalitete i produljenog roka trajanja. U prehrambenoj industriji,  konvekcijsko sušenje u struji vrućeg zraka i dalje je jedna je od najčešćih tehnoloških operacija za dobivanje suhog proizvoda. Međutim, konvekcijsko sušenje ima određene nedostatke i ograničenja u pogledu kvalitete proizvoda i energetske učinkovitosti. U novije vrijeme, navedena ograničenja mogu se svesti na najmanju moguću mjeru uvođenjem kombinacije inovativnih netoplinskih tehnologija i hibridnog sušenja. Ultrazvučna predobrada i predobrada visokim tlakovima mogu dovesti do pozitivnih  fizikalno-kemijskih promjena, kao i poboljšati prijenos mase. Hibridno sušenje predstavlja kombinirani postupak sušenja koji koristi više tehnika sušenja, a može djelovati sinergijski te rezultirati kraćim vremenom sušenja i manjom potrošnjom energije uz zadržavanje kvalitativnih svojstava sušenog materijala. Cilj ovog projekta je istražiti utjecaj inovativnih tehnologija predobrade (ultrazvuk, visoki tlakovi) na učinkovitost sušenja, fizikalno-kemijska i nutritivna svojstva nedovoljno iskorištenog otpada avokada  i nusproizvoda bundeve  u definiranim uvjetima sušenja u hibridnoj kondukcijsko-vakuumskoj sušari i hibridnoj mikrovalno-konvekcijskoj sušari. Tijekom proizvodnje i skladištenja posebno su važna sorpcijska svojstva osušenog materijala te će stoga biti razvijeni različiti kinetički modeli  koji će se koristiti za odabir odgovarajućih uvjeta skladištenja i pakiranja i na taj način optimirati zadržavanje  poželjnih svojstava boje, teksture, hranjivih tvari i bioloških aktivnih spojeva, kao i uvjete sušenja i rehidratacije osušenog materijala.]]></summary_hr><summary_en><![CDATA[Drying is one of the oldest food preservation process. There are numerous drying techniques offered to dehydrate different kinds of raw materials in order to obtain products of a high quality and extended shelf-life. In food processing, convective hot-air drying is still one of the most extensively used method for dehydration of food products. However, it has some disadvantages and limitations regarding product quality and energy efficiency. Those limitations might be minimized by introducing the combination of the innovative non-thermal pretreatment technologies and hybrid drying technologies. Ultrasound and high pressure pretreatments could provide some beneficially physical or chemical changes as well as to enhance mass transport. Hybrid drying, a combined drying approach which utilizes more drying techniques, can provide a synergistic effect resulting in decreased drying time and energy consumption while maintaining most quality attributes.  The objective of this project is to investigate the effect of innovative pre-treatment technologies  (ultrasound, high pressures) on the drying efficiency, physico-chemical and nutritive properties of underutilized avocado waste and pumpkin byproducts in defined drying conditions in a hybrid conductive-vacuum dryer and a hybrid microwave-convective dryer. Particularly important during production and storage of the dried material are the sorption properties.  Different kinetic models will be developed. Such data can be used for selecting appropriate storage conditions and packaging systems that optimize the retention of color, texture, nutrients and biologically active compounds as well as optimize the drying or rehydration conditions of a dried material.]]></summary_en></project><project>
<id>8857</id><title_hr><![CDATA[Integrativna analiza signalnih puteva fitohormona uključenih u odgovor biljaka krumpira na infekciju viroidom vretenastoga gomolja krumpira]]></title_hr><title_en><![CDATA[Integrative analysis of phytohormone signaling pathways involved in potato response to infection with Potato spindle tuber viroid]]></title_en><user_id>5012</user_id><user_firstLast_name>Snježana Mihaljević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-9915</code><acronim><![CDATA[PotatoSignalHub]]></acronim><duration>01.03.2020 - 29.07.2024</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>26396, 26695, 3746, 25016, 20437, 25770, 3965, 26285, 861744, 866019, </team_members_id><team_members_names><![CDATA[Jana Oklešťková, César Llave, Dunja Leljak-Levanić, Mateja Jagić, Snježana Kereša, Ivanka Habus Jercic, Ana Smolko, Sabine Rosahl, Iva Marković, Bernard Jarić, ]]></team_members_names><keywords_hr><![CDATA[analiza transkriptoma, fitohormoni, jasmonska kiselina, krumpir, miRNA, razvoj simptoma, signalni putovi, salicilna kiselina, viroid, PSTVd]]></keywords_hr><keywords_en><![CDATA[jasmonic acid, miRNA, phytohormones, potato, PSTVd, salycilic acid, signaling pathways, symptome development, transcriptome analysis, viroid]]></keywords_en><summary_hr><![CDATA[Viroid vretenastoga gomolja krumpira (Potato spindle tuber viroid, PSTVd) je najvažniji subviralni patogen krumpira (Solanum tuberosum L.). Zbog široke rasprostranjenosti u svijetu i patogenog učinka na mnoge poljoprivredne kulture, zaraza viroidom PSTVd može predstavljati ograničenje u proizvodnji hrane. Molekularni mehanizmi kojima viroidi induciraju kompleksne promjene u ekspresiji gena i metabolizmu biljaka domaćina nisu u potpunosti razjašnjeni. Novija saznanja ukazuju  da fitohormoni posreduju u regulaciji mnogih signalnih putova uključenih u interakciju biljaka i viroida. Glavni cilj ove studije je analizirati dinamiku odgovora biljaka krumpira na infekciju viroidom PSTVd kako bi dobili uvid u fitohormonima-posredovane odgovore na infekciju i pojasnili ulogu fitohormona u razvoju simptoma. U ovoj studiji provesti ćemo sustavno istraživanje ekspresije gena i endogenih fitohormona kako bi bolje razumjeli fiziološko značenje promjena u statusu fitohormona tijekom napredovanja bolesti. Doprinos jasmonske kiseline (JA) i salicilne kiseline (SA) u odgovoru na infekciju viroidom PSTVd  istražit ćemo koristeći transgenične linij e krumpira koje nemaju mogućnost nakupljanja JA i SA, kako bi utvrdili može li nedostatak fitohormona biti povezan sa sistemskim odgovorom i karakteristikama simptoma. Analizu transkriptoma listova sistemski zaraženih ne-transgeničnih i transgeničnih linija krumpira provesti ćemo kako bi dobili detaljan uvid u diferencijalno eksprimirane gene uključene u signalne putove fitohormona i njihove interakcije. Nadalje, promjene u ekspresiji tih gena biti će uspoređen s profilom ekspresije nekih konzerviranih miRNA s ciljem identificikacije miRNA uključenih u modulaciju signalnih putova fitohormona tijekom odgovora krumpira na zarazu viroidom PSTVd. Nova saznanja mogu pridonijeti boljem razumijevanju kompleksnih interakcija biljaka i viroida te pomoći razvoj strategija za zaštitu biljaka od ovog patogena.]]></summary_hr><summary_en><![CDATA[Potato spindle tuber viroid (PSTVd) is the most important subviral pathogen of potato (Solanum tuberosum L.). Due to its worldwide distribution and its capacity to cause disease in many important crop plants, PSTVd is one of the main constraints on food production. The molecular mechanisms by which viroids induce complex changes in host gene expression and metabolism are not fully understood. Current findings indicate that many signal transduction pathways involved in plant-viroid interactions are mediated by phytohormones. The main goal of this study is to analyze the dynamic of potato-PSTVd interaction, in order to obtain a more comprehensive view of phytohormone-mediated responses to PSTVd infection, and to clarify their role in symptom development. During the study, a systematic exploration of gene expression and endogenous phytohormones along the progression of disease will be conducted to better understand the physiological meaning of changes in the status of phytohormones associated to viroid infection. To assess the contribution of jasmonic acid (JA) and salicylic acid (SA) in response to PSTVd infection, JA- and SA-deficient transgenic potato lines will be used in order to determine whether the lack of phytohormones could be implicated in the systemic response and symptom characteristics.  Transcriptome analysis in leaves of systemically infected non-transgenic and transgenic potato lines will be employed to achieve higher resolution of differentially expressed genes (DEGs) involved in phytohormone signaling pathways and their crosstalk. In addition, the profiles of DEGs will be compared with profiles of some conserved miRNAs to identify viroid-responsive miRNAs implicated in the modulation of phytohormone signaling in potato during PSTVd infection. New findings can contribute to better understanding of the complexity of plant-viroid interactions and to support the development of new strategies for plant protection against viroids.]]></summary_en></project><project>
<id>8861</id><title_hr><![CDATA[Tehnologija preprekama i 3D printanje za okolišno prihvatljivu proizvodnju funkcionalnih voćnih sokova]]></title_hr><title_en><![CDATA[Hurdle technology and 3D printing for sustainable fruit juice processing and preservation]]></title_en><user_id>2615</user_id><user_firstLast_name>Danijela Bursać Kovačević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-2105</code><acronim><![CDATA[3D-SustJuice]]></acronim><duration>01.03.2020 - 31.08.2024</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Prehrambena tehnologija, Interdisciplinarne biotehničke znanosti, </scie_field_hr><scie_field_en>Food technology, Interdisciplinary biotechnical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Food Technology and Biotechnology]]></institution_en><team_members_id>1011, 214, 416, 26297, 26300, 26315, 13352, 2853, 19662, 24212, 24300, 26159, 26400, 23329, 23664, 858394, </team_members_id><team_members_names><![CDATA[Ksenija Durgo, Jadranka Frece, Ksenija Markov, Daniel Granato, Ilija Đekić, Igor Tomašević, Tomislav Bosiljkov, Adela Krivohlavek, Martina Ivešić, Ivana Mandic Andacic, Predrag Putnik, Iva Palac Bešlić, Filip Valjak, Ana Huđek, Deni Kostelac, Anica Bebek Markovinović, ]]></team_members_names><keywords_hr><![CDATA[Tehnologija preprekama, 3D printanje, funkcionalni voćni sok, autohtone voćne vrste, održivost]]></keywords_hr><keywords_en><![CDATA[Hurdle technology, 3D print, functional fruit juice, autochthonous fruit, sustainability ]]></keywords_en><summary_hr><![CDATA[Republika Hrvatska (RH) ima dugu tradiciju uzgoja voća zbog posebnog zemljopisnog položaja, klimatskih prilika te kvalitetne sirovine. Unatoč dobrim morfološko–pomološkim karakteristikama starih autohtonih voćnih vrsta, njihov nutritivni sastav te biološki potencijal nedovoljno je istražen, kao i mogućnost prerade u funkcionalne voćne sokove, koji su u velikoj potražnji na tržištu. Sve veća intolerancija na laktozu i nemogućnost konzumacije funkcionalnih mliječnih proizvoda otvara mogućnost prerade ovih voćnih vrsta u funkcionalne voćne sokove. Preradom u sok, generira se značajan udio nusproizvoda koji predstavlja odličan izvor biološki aktivnih spojeva (BAS). Stoga će se ovim projektom ispitati uporaba selektiranih autohtonih voćnih vrsta u održivoj proizvodnji funkcionalnih voćnih sokova uz dodatak odabranih probiotičkih kultura i BAS-a izoliranih iz nusproizvoda. Klasična toplinska obrada (pasterizacija) narušava stabilnost termolabilnih molekula BAS-a, stoga će se istražiti primjena „tehnologije preprekama“ („hurdle“) tj. kombinacija netoplinskih tehnologija ultrazvuka visokog intenziteta (HPU) i pulsirajućeg električnog polja (PEF). S ciljem spajanja tradicije i inovacije primijeniti će se aditivna tehnologija 3D-printanja (3DP) za dizajn proizvoda jedinstvenog sastava i geometrije te produženog roka trajanja. 3DP funkcionalni voćni sokovi proizvedeni od autohtonih voćnih vrsta predstavljat će jedinstvene hrvatske voćne suvenire, a u skladu  s temeljnim smjernicama kružnog gospodarstva i turizma RH. Tako se cilja razviti održive načine prerade koji će potrošaču osigurati unikatan, nutritivno vrijedan, zdravstveno ispravan, atraktivan i kvalitetan prehrambeni proizvod na ekonomski prihvatljiv način.]]></summary_hr><summary_en><![CDATA[Republic of Croatia has a long tradition of fruit cultivation due to its geographic position, climatic conditions and high quality of fruit crops. Autochthonous fruit varieties are characterized by good morphological/pomological characteristics, but their nutritional and biological potential have been underestimated, as well as their ability to be processed into juices that are in high demand on the market. Increased lactose intolerance in population that is complemented with inability to consume functional dairy products led to the opportunity for processing of autochthonous fruit varieties into functional fruit juices. During the processing into juice, a significant amount of by-products is produced. This represents a high-value raw material for the isolation of biologically active compounds (BACs). Therefore, this project will examine the use of selected autochthonous fruit species in sustainable production of functional juices with addition of selected probiotic cultures and/or BACs isolated from the by-products. Classical heat treatment (pasteurization) disrupts the stability of the thermoluble BAS molecules, so the application of nonthermal &#39;&#39;hurdle technology&#39;&#39;, i.e. the combination of high intensity ultrasound (HPU) and pulse electric field (PEF) technology will be investigated.In order to combine tradition and innovation, additive technology e.g. 3D-printing (3DP) will be applied to design products of unique composition, geometry and extended shelf-life. 3DP functional fruit juices produced from autochthonous fruit varieties will represent unique Croatian fruit souvenirs, in line with the core principles of the Croatian circular economy and tourism. That way the aim is to develop sustainable ways of processing that will provide the consumers with a unique, healthy, attractive, and high quality food product in an economically acceptable way.]]></summary_en></project><project>
<id>8866</id><title_hr><![CDATA[Novi životi antičkih natpisa: epigrafski spoliji na području srednje Dalmacije]]></title_hr><title_en><![CDATA[The new lives of ancient inscriptions: Epigraphic spolia from the territory of central Dalmatia]]></title_en><user_id>7515</user_id><user_firstLast_name>Dino Demicheli</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-3537</code><acronim><![CDATA[EpiSpolia]]></acronim><duration>01.01.2020 - 31.12.2023</duration><status>Završio</status><financ_value>70.940,34 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Arheologija, </scie_field_hr><scie_field_en>Archeology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>26839, 7522, 26830, 26911, 26806, 26983, 26816, 26795, 23208, 26835, 864922, </team_members_id><team_members_names><![CDATA[Vanja Kovačić, Marina Milićević Bradač, Ivan Matijević, Lorenzo Calvelli, Ema Višić-Ljubić, Ante Jurčević, Vinka Marinkovic, Toni Glučina, Josip  Parat, Nino Švonja, Krešimir Grbavac, ]]></team_members_names><keywords_hr><![CDATA[Spoliji, antička epigrafija, natpisi, arheologija, srednja Dalmacija, Salona, Split]]></keywords_hr><keywords_en><![CDATA[Spolia, Latin and Greek epigraphy, inscriptions, archaeology, Central Dalmatia, Salona, Split]]></keywords_en><summary_hr><![CDATA[Antički epigrafski spomenici su u razdoblju od svog nastanka do danas bili iskorištavani za mnoge utilitarne funkcije koje im nisu bile izvorno namijenjene te se takvi spomenici nazivaju epigrafskim spolijima. Kako se uglavnom radi o kamenim spomenicima, najčešća naknadna uporaba je ona građevinska, ali poznati su i mnogi drugi načini na koje su ljudi koristili antičke epigrafske spomenike. Ovakva je pojava zabilježena na svim područjima na kojima je vidljiva prisutnost klasičnih civilizacija, a prostor Dalmacije je radi svoje goleme antičke arheološke ostavštine jedan od najbolje potvrđenih po pitanju epigrafskih spomenika. Mnogi su natpisi pronađeni kao spoliji, no dosad nije napravljena znanstvena studija koja bi tematizirala ovaj kulturološki fenomen i koja bi na jedno mjesto objedinila epigrafske spolije s nekog većeg područja.Ovaj projekt ima dva dijela koja se međusobno nadopunjuju: prvi dio je taj da se dokumentiraju i znanstveno valoriziraju svi poznati epigrafski spoliji na prostoru srednje Dalmacije, kako oni koji se danas nalaze u muzejima i zbirkama, tako oni koji su još uvijek in situ. Drugi dio projekta obuhvaća arheološka istraživanja salonitanskih bedema s namjerom pronalaska epigrafskih spolija u njima, budući da su od početka istraživanja ovih bedema mnogi natpisi ondje pronađeni, a koji su se u antičko i kasnoantičko vrijeme (2-7. st.) koristili kao običan građevinski materijal. Znanstveni rezultati bit će prezentirani javnosti, kako znanstvenoj tako i široj putem javnih predavanja, kongresa i znanstvenih članaka, ali neki će se spomenici očistiti, konzervirati i u novome obliku predstaviti javnosti. Jedan od načina na koje bi ova često nevidljiva baštine došla do što većeg broja ljudi, posebno mlađe populacije, jest taj da će se u blizini in situ spolija, posebice u urbanim cjelinama, postaviti QR kodovi preko kojih će se moći dobiti razumljiva informacija o spomeniku i koja će biti trajno pohranjena u digitalnom obliku.]]></summary_hr><summary_en><![CDATA[From the times of their creation until today, ancient epigraphic monuments have been exploited for many utilitarian functions that were not originally intended for and these monuments are called epigraphic spolia. They are mostly stone monuments and the most common use is for building, but there are many other purposes for which the ancient epigraphic monuments were used. This phenomenon has been observed in all areas where the presence of classical civilizations is visible, and the Dalmatian space is one of the best-known when speaking of ancient archeological legacy through the epigraphic monuments. Many inscriptions have been found as spolia, but so far no scientific study has been carried out to address this cultural phenomenon and that would incorporate epigraphic spolia from one larger area into one survey.This project has two parts that complement each other: the first part is to document and scientifically valorize all known epigraphic spolia in Central Dalmatia, both, those who are now in museums and collections, and those which are still in situ. The second part of the project encompasses archeological excavations of the Salonitan ramparts with the intent of finding epigraphic spolia, since numerous inscriptions have been found in these ramparts which were used as ordinary building materials in classical Roman and late antique times (2nd-7th c.). The scientific results will be presented to the community through public lectures, congresses and scientific articles; some of the monuments will be cleaned, conserved and presented to the public in a new form. One of the ways for this often-invisible heritage to reach an as broader community, especially the younger populations, is to set QR codes next to in situ spolia so the information about particular monument could be reachable, understandable and permanently stored in digital form.]]></summary_en></project><project>
<id>8877</id><title_hr><![CDATA[Metode za 3D rekonstrukciju i analizu kroničnih rana]]></title_hr><title_en><![CDATA[Methods for 3D reconstruction and analysis of chronic wounds]]></title_en><user_id>5672</user_id><user_firstLast_name>Damir Filko</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2019-04</proposal_call><code>UIP-2019-04-4889</code><acronim><![CDATA[Vision4Wounds]]></acronim><duration>01.01.2020 - 31.12.2024</duration><status>Završio</status><financ_value>190.125,42 eur</financ_value><scie_area_hr>Tehničke znanosti, Biomedicina i zdravstvo, </scie_area_hr><scie_area_en>Technological sciences, Biomedicine and health sciences, </scie_area_en><scie_field_hr>Računarstvo, Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Computer sciences, Clinical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera Osijek, Fakultet elektrotehnike, računarstva i informacijskih tehnologija Osijek]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Electrical Engineering, Computer Science and Information Technology Osijek]]></institution_en><team_members_id>2970, 6231, 865759, </team_members_id><team_members_names><![CDATA[Emmanuel Karlo  Nyarko, Dražen Bajer, Bruno Zorić, ]]></team_members_names><keywords_hr><![CDATA[kronična rana, detekcija, 3D rekonstrukcija, segmentacija, klasifikacija tkiva, robotski manipulator, 3D kamera]]></keywords_hr><keywords_en><![CDATA[chronic wound, detection, 3D reconstruction, segmentation, tissue classification, robot manipulator, 3D camera]]></keywords_en><summary_hr><![CDATA[Cijeljenje kronične rane je dugotrajan proces koji se može dodatno produljiti ako se ne uporabi adekvatni tretman. Liječniku je potrebna objektivna pretraga kojom bi mogao sa sigurnošću utvrditi da li je određen tretman adekvatan ili je potrebno upotrijebiti neku drugu metodu. Ovaj projekt ima za cilj istraživanje i razvoj potpuno automatskog sustava koje će pomoću robotskog manipulatora i modernih 3D kamera omogućavati dobivanje precizne 3D rekonstrukcije dijela ljudskog tijela na kojem se rana nalazi. Automatski će se segmentirati područje rane na snimljenom volumenu, te klasificirati pojedine tipove tkiva na rani. Realiziranje i primjena ovog sustava bi rezultiralo kompletno objektivnim mjerenjem fizičkih dimenzija rane (opsega, površine i volumena), te postotnih udjela pojedinog tipa tkiva rane (nekroza, fibrin i granulacija). Pošto bi dobiveni podaci znatno doprinijeli određivanju adekvatne terapije pacijenta smanjili bi se troškovi liječenja, a zbog potpuno automatiziranog sustava smanjilo bi se vrijeme obrade pacijenta što bi omogućilo da veći broj pacijenata bude obrađen u istom vremenu. Razvijeni sustav bi stoga znatno doprinio povećanju kvalitete liječenja pacijenata, smanjenju troškova i time poboljšanju zdravstvenog sustava u cjelini. Pored razvoja automatskog sustava za analizu rana, doprinos ovom području istraživanja bit će i javna objava anotirane baze snimaka i 3D modela koju bi ostali istraživači mogli javno koristiti za vlastita istraživanja, analize i vrednovanje razvijenih algoritama. ]]></summary_hr><summary_en><![CDATA[Chronic wounds heal very slowly and the healing process may further be prolonged if an ineffective treatment is used. Clinicians need an objective wound characterization method to decide whether the current treatment is adequate or requires modifications. The goal of this project is to research and develop a completely automatic system for precise 3D reconstruction of the wound affected area of the human body with the help of a robot manipulator and modern 3D camera. The system will automatically segment the wound area of the recorded volume and classify individual tissue types present in the wound. Implementation and application of the proposed system would result in a completely objective measurement of the physical parameters of the wound (circumference, area, volume) and percentages of individual tissue types present in the wound (necrotic, fibrin, granulation). These measurements would greatly contribute in determining adequate patient treatment and would therefore reduce overall cost of healing. Furthermore, due to the completely automated system for measurement, patient examination time would decrease which would enable more patients to be examined in the same amount of time. The developed system would therefore significantly contribute to the increase of patient treatment quality, cost reduction and consequently improve healthcare as a whole. Besides development of the automated system for wound analysis, this project would contribute in this field of study by enabling open access to a database of annotated wound recordings and 3D models which other researchers could use for their own research, analysis and benchmarking of developed systems and algorithms.]]></summary_en></project><project>
<id>8879</id><title_hr><![CDATA[Cementom stabilizirani nosivi slojevi s otpadnom gumom za održive kolnike]]></title_hr><title_en><![CDATA[Cement stabilized base courses with waste rubber for sustainable pavements]]></title_en><user_id>5128</user_id><user_firstLast_name>Ivana Barišić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2019-04</proposal_call><code>UIP-2019-04-8195</code><acronim><![CDATA[RubSuPave]]></acronim><duration>02.01.2020 - 01.01.2025</duration><status>Završio</status><financ_value>176.660,69 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Građevinarstvo, </scie_field_hr><scie_field_en>Civil engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Građevinski i arhitektonski fakultet Osijek]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Civil Engineering and Architecture Osijek]]></institution_en><team_members_id>5409, 22521, 12972, 2971, 26776, 26849, 26852, 26838, 855337, </team_members_id><team_members_names><![CDATA[Martina Zagvozda, Tihomir Dokšanović, Ivan Radić, Mario Galić, Sanja Šurdonja, Marijana Cuculić, Ivana Pranjić, Rok Cajzek, Matija Zvonarić, ]]></team_members_names><keywords_hr><![CDATA[cementom stabilizirani nosivi slojevi, guma, kolnička konstrukcija, održivi razvoj, reflektivne pukotine]]></keywords_hr><keywords_en><![CDATA[cement stabilised base courses, rubber, pavement structure, sustainable development, reflective cracks]]></keywords_en><summary_hr><![CDATA[Cementom stabilizirani nosivi slojevi (CNS) povećavaju nosivost kolnika i otpornost na smrzavanje te su dobra podloga kolničkom zastoru. Međutim, u CNS se razvijaju pukotine od skupljanja materijala koje se reflektiraju na površini zastora. Primjena otpadne gume u CNS ima potencijal smanjenja nastanka pukotina u tom sloju te posljedično i reflektivnih pukotina. Ovo smanjuje potrebu za održavanjem kolnika i produljuje njegov vijek trajanja. Do sada nije do kraja istražna mogućnost primjene otpadne gume u CNS obzirom na optimalni sastav, a posebice utjecaj na ponašanje asfaltnog zastora. Aktivnosti u sklopu ovog projekta su usmjerene na rješavanje i poboljšanje praktičnog cilja: stvaranje održivog kolnika kroz primjenu otpadnog materijala i produljenje vijeka trajanja kolničke konstrukcije. Važnost teme očituje se u potrebi proširenja dosadašnjih laboratorijskih istraživanja koja su bila na razini jednog materijala (CNS) na promatranje kolničke konstrukcije kao cjeline te prijenos laboratorijskih rezultata na model stvarne konstrukcije. Kroz aktivnosti: 1. uspostava istraživačke grupe; 2. laboratorijsko istraživanje, 3. numeričko modeliranje, 4. izrada optimizacijskog modela; 5. terensko istraživanje (izgradnja probnog polja) i 6. aktivnosti unutar vidljivosti želi se postići glavni cilj: razvoj novog materijala za izgradnju nosivih slojeva kolničke konstrukcije povećane otpornosti na razvoj reflektivnih pukotina. Specifični ciljevi:  Uspostava nove istraživačke grupe od znanstvenika iz različitih grana građevinarstva; istraživanje mogućnost primjene otpadne gume u CNS eksperimentalnim metodama; definiranje optimalne mješavine optimizacijskim modelom; istraživanje mogućnosti primjene otpadne gume u kolničkim konstrukcijama numeričkim metodama; istraživanje ponašanja kolničke konstrukcije s CNS s otpadnom gumom u realnim uvjetima; prijava projektnog prijedloga istraživačke grupe na druge izvore financiranja; diseminacija i upravljanje provedbom projekta.]]></summary_hr><summary_en><![CDATA[Cement Stabilized Base Courses (CBC) increase pavement bearing capacity and frost resistance and present good base for wearing courses. Nonetheless, cracks are emerging in the CBC from material shrinkage which are reflected on the asphalt surface. The use of waste rubber in the CBC have cracks reduction potential, which will result in reflective cracks reduction. This will reduce the need for road maintenance and extend its lifespan. Until now, the possibility of using waste rubber in CBC with regard to the optimal mixture composition, and in particular the effect on asphalt wearing course behaviour has not been fully investigated. Activities within this project aim to solving and improving the practical goal of creating a sustainable pavement through the application of waste materials and extending pavement life span. The theme importance is manifested in the need to extend the laboratory-level research at the level of a single material (CBC) to investigate pavement construction as a whole and transfer laboratory results to the model of an actual construction. By activities: 1. the establishment of a research group; 2. laboratory research, 3. numerical modelling, 4. development of optimization model; 5. field research (construction of test field) and 6. activity within visibility main goal is to achieved: development of new material for the construction of pavement base course with increased resistance to the development of reflective cracks. Specific objectives: Establishment of a new research group by scientists from different branches of civil engineering; Research on the possibility of using waste rubber in CBC by experimental methods; Defining optimal mixture by optimization model; Research on the possibility of using waste rubber in CBC by numerical methods; Real condition pavement behaviour research with CBC with waste rubber; Application of project proposal to other sources of funding; Disinformation and Project Implementation Management.]]></summary_en></project><project>
<id>8881</id><title_hr><![CDATA[Ravnoteža sila i momenta sila u diobenom vretenu]]></title_hr><title_en><![CDATA[Balance of forces and torques in the mitotic spindle]]></title_en><user_id>6276</user_id><user_firstLast_name>Nenad Pavin</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-5967</code><acronim><![CDATA[SpindleForceBalance]]></acronim><duration>01.02.2020 - 31.01.2024</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, Biologija, </scie_field_hr><scie_field_en>Physics, Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>11207, 25723, 26497, 865242, 13281, </team_members_id><team_members_names><![CDATA[Iva Tolić, Arian Ivec, Monika Trupinić, Ana Petelinec, Maja Novak, ]]></team_members_names><keywords_hr><![CDATA[sile i momenti sila, diobeno vreteno, mikrotubuli, model srednjeg polja, mikroskopija]]></keywords_hr><keywords_en><![CDATA[forces and torques, mitotic spindle, microtubules, mean-field model, microscopy]]></keywords_en><summary_hr><![CDATA[Diobeno vreteno je samoorganizirani mikro stroj sastavljen od mikrotubula i pripadajućih proteina, a dijeli genetski materijal između dvije stanice kćeri u nastajanju. Sile koje djeluju u diobenom vretenu tijekom mitoze ključne su za njegovo funkcioniranje u svakoj fazi. U metafazi, diobeno vreteno ima prepoznatljiv oblik s karakterističnim rasporedom mikrotubula. Mikrotubuli se protežu između suprotnih polova vretena, a međudjelu s kromosomima i međusobno. Sile koje djeluju na kinetohorne mikrotubule drže kromosome pod napetošću u metafaznoj ploči, što pridonosi utišavanju kontrolne točke udiobenom vretenu. Iako je postignut značajan napredak u razumijevanju mehanike vretena, pitanje ravnoteže sile u diobenom vretenu je još uvijek predmet znanstvene rasprave. Glavna ideja ovog projekta je istražiti ravnotežu sile cijelog vretena, na temelju našeg prethodnog rada na pojedinačnimsnopovima mikrotubula. Opisat ćemo ravnotežu sile vretena uvođenjem pristupa srednjeg polja gdje će se diskretni snopovi mikrotubula u određenom području, zajedno sa silama i momentima sila tih snopova, aproksimirati prosječnim snopom. Model će dati predviđanja za sile i momente sila u vretenu, te će stoga predvidjeti oblik cjelokupnog vretena uključujući oblike unutarnjeg i vanjskog snopa. Predviđeni oblici će se usporediti s oblicima promatranim u našim eksperimentima. Na temelju tih informacija ponudit ćemo mehaničko objašnjenje oblika unutarnjih i vanjskih snopova, uključujući velike razlike između njih. Ovaj pristup će pružiti sveobuhvatan uvid u sile i momente sila koji djeluju u cijelom vretenu, koji su ključni za pravilnu diobu stanica.]]></summary_hr><summary_en><![CDATA[The mitotic spindle is a self-organized micro-machine composed of microtubules and the associated proteins, which divides genetic material between the two nascent daughter cells. Forces exist in the spindle throughout mitosis and are crucial for spindle functioning in each phase. In metaphase, the mitoticspindle has a recognizable shape with a characteristic arrangement of microtubules. Microtubules extend from the opposite spindle poles and interact with the chromosomes and with each other. Forces exerted by kinetochore microtubules keep the chromosomes under tension at the metaphase plate,which contributes to silencing of the spindle assembly checkpoint. Though a significant progress in understanding the mechanics of the spindle is achieved, the question of force balance in the spindle is still under debate. The central idea of this project is to explore the force balance of the entire spindle, based on our previous work on individual microtubule bundles. We will describe the force balance of the spindle by introducing a mean-field approach where discrete microtubule bundles in a certain region, together with forces and torques exerted by these bundles, will be approximated by an averaged bundle.The model will provide predictions for forces and torques in the spindle, and consequently it will predict the shape of the entire spindle including the shapes of inner and outer bundles. The predicted shapes will be compared with shapes observed in our experiments. Based on such information, we will provide a mechanical explanation for shapes of inner and outer bundles, including major differences between them. This approach will provide comprehensive insight in forces and torques acting in the entire spindle, which are crucial for proper cell division.]]></summary_en></project><project>
<id>8893</id><title_hr><![CDATA[Uloga imunih semaforina u nealkoholnoj masnoj bolesti jetre i sepsi]]></title_hr><title_en><![CDATA[The role of immune semaphorins in NAFLD and sepsis]]></title_en><user_id>3443</user_id><user_firstLast_name>Neven Papić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2019-04</proposal_call><code>UIP-2019-04-7194</code><acronim><![CDATA[SepsisFAT]]></acronim><duration>01.03.2020 - 28.02.2025</duration><status>Završio</status><financ_value>217.646,69 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Kliničke medicinske znanosti, Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Clinical sciences, Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>9980, 26202, 26251, 26034, 26956, 5729, 26044, 26912, 26322, 865447, 865205, 29177, </team_members_id><team_members_names><![CDATA[Marko Kutleša, Ivana Knežević Štromar, Viktor Kotarski, Anita Atelj, Branimir Gjurašin, Iva Butić, Juraj Krznarić, Maja Mijić, Vladimir Krajinović, Nina Vrsaljko, Karlo Jeličić, Leona Radmanić, ]]></team_members_names><keywords_hr><![CDATA[sepsa, nealkoholna masna bolest jetre, imunološki odgovor, upala, semaforini]]></keywords_hr><keywords_en><![CDATA[sepsis, non-alcoholic fatty liver disease, immune response, inflammation, semaphorins]]></keywords_en><summary_hr><![CDATA[Jetra ima središnju ulogu u regulaciji upale proizvodnjom proteina akutne faze, komplementa i citokina. Tek nedavno se počela otkrivati uloga jetre u sepsi. Pokazalo se da uravnoteženi odnos upalnog i protuupalnog odgovora jetre rezultira eliminacijom bakterija i rezolucijom upale. Nealkoholna masna bolest jetre (eng. NAFLD) je najčešća kronična bolest jetre, a povezana je sa sustavnim promjenama imunološkog odgovora koje potiču progresiju u steatohepatitis, cirozu jetre i razvoj hepatocelularnog karcinoma. Iako postoje brojne imunološke veze između sepse i NAFLD-a, uloga NAFLD-a u prognozi i tijeku sepse nije poznata. Semaforini su nedavno prepoznati kao jedan od ključnih regulatora imunološkog odgovora; dok neki inhibiraju aktivaciju i proliferaciju imunih stanica te smanjuju proizvodnju upalnih citokina, drugi stimuliraju imunološki odgovor. U prethodnim istraživanjima pokazali smo da su semaforini uključeni u patogenezu virusnih hepatitisa i progresiju fibroze, no njihova uloga u NAFLD-u i sepsi još nije opisana. Hipoteza ovog projekta je da su semaforini regulatori upale u bolesnika s NAFLD-om koji utječu na ishod sepse. Radi se o prospektivnoj, neintervencijskoj studiji. Glavni ciljevi su: (a) identificirati semaforine koji su povezani s NAFLD-om, (b) analizirati utjecaj NAFLD-a na tijek i ishod sepse; (c) analizirati promjene u koncentraciji semaforina prema stadiju steatoze u bolesnika sa sepsom i povezanost s kliničkim ishodima; (d) analizirati povezanost semaforina s profilom upalnih i protuupalnih citokina prema stadiju steatoze u bolesnika sa sepsom; (e) analizirati promjene u koncentraciji semaforina i profil imunološkog odgovora u bolesnika s teškom pneumonijom; (f) identificirati polimorfizam semaforinskih gena povezan s NAFLD-om i njihov utjecaj na ishod sepse. Semaforini bi mogli biti novi dijagnostički i prognostički biomarkeri, s terapijskim potencijalom imunomodulacije u sepsi u svrhu zaštite oštećenja organa u bolesnika s NAFLD-om.]]></summary_hr><summary_en><![CDATA[The liver, with its ability to produce acute phase proteins, complement and cytokines, plays a central role in regulating inflammation. A balanced pro- and anti-inflammatory liver response results in bacterial clearance and resolution of inflammation. Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease associated with systemic changes in immune response. Although there are numerous immunological links between sepsis and NAFLD, there is a significant gap in knowledge regarding the role of NAFLD in sepsis. Semaphorins were recently recognized as one of the key regulators of immune responses; while some suppress immune cells activation, proliferation and production of inflammatory cytokines, others stimulate immune responses. We have previously shown that semaphorins are associated with pathogenesis of viral hepatitis and progression of fibrosis. However, their role in NAFLD and sepsis is unknown. The hypothesis of this project is that semaphorins are regulators of inflammation in patients with NAFLD that have impact on sepsis outcome. This study is designed as a prospective, non-interventional study. The main aims are: (a) to identify semaphorins that are associated with NAFLD, (b) to analyze the impact of NAFLD on sepsis outcomes; (c) to analyze changes in semaphorin concentration according to steatosis grade in patients with sepsis and its impact on clinical outcomes; (d) to describe correlation of semaphorins with the profile of pro- and anti-inflammatory cytokines in patients with sepsis; (e) to analyze the changes in semaphorin concentration and the profile of immune response in patients with severe community acquired pneumonia; (f) to identify semaphorin gene polymorphism associated with NAFLD and its impact on sepsis outcomes. Semaphorins could be a novel diagnostic and prognostic biomarkers as well as targets for immune modulation in sepsis aimed at protecting organs from injury in patients with NAFLD. ]]></summary_en></project><project>
<id>8901</id><title_hr><![CDATA[Multifaktorna analiza HPV inficiranih stanica u nastanku raka vrata maternice]]></title_hr><title_en><![CDATA[Multifactor analysis of HPV infected cells in cervical cancer development]]></title_en><user_id>898</user_id><user_firstLast_name>Ivan Sabol</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-3403</code><acronim><![CDATA[MACCD]]></acronim><duration>10.01.2020 - 09.07.2024</duration><status>Završio</status><financ_value>131.528,30 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>25530, 23297, 25850, 3294, 572, 25847, 4183, 858344, 13064, </team_members_id><team_members_names><![CDATA[Ivana Erceg Ivkošić, Rajko Fureš, Branka Molnar Stantić, Nina  Milutin Gašperov, Magdalena Grce , Tomas Kalina, Anja Barešić, Ena Pešut, Ivana Šimić, ]]></team_members_names><keywords_hr><![CDATA[HPV, masena citometrija, CyTOF, rak vrata maternice, biomarkeri]]></keywords_hr><keywords_en><![CDATA[HPV, mass cytometry, CyTOF, cervical cacner, biomarkers]]></keywords_en><summary_hr><![CDATA[Rak vrata maternice (RVM) je 4. rak u žena u svijetu te u Europi godišnje uzrokuje smrt oko 13.000 žena. Programi probira i cijepljenje protiv humanog papiloma virusa (HPV) nude značajnu zaštitu, no imaju specifične probleme. Cijepljenje je manje učinkovito ako se primjenjuje nakon izlaganja HPV-u, i ako se primjenjuje propisno, ne štiti od svih vrsta HPV-a koje uzrokuju RVM. Programi probira, ovisno o korištenoj metodi, citologiji ili HPV-testiranju, imaju ili smanjenu osjetljivost ili specifičnost, no još uvijek imaju visoke negativne prediktivne vrijednosti i u zemljama gdje se primjenjuju su se pokazali kao vrlo učinkoviti u smanjenju smrtnosti. Međutim, pozitivna prediktivna vrijednost (PPV) za otkrivanje žena s visokim rizikom razvoja RVM ostaje slaba, smanjujući efikasnost programa probira budući da se veliki broj žena upućuje na skupe zahvate koji možda i nisu nužni. Osim novčanih troškova, prekomjerno liječenje žena, često reproduktivne dobi, nosi rizike, a može dovesti i do komplikacija u trudnoći, uključujući pobačaj. Ovim projektom želimo istražiti panel od 30 staničnih biljega koji koreliraju s tijekom bolesti korištenjem najsuvremenije metode masene citometrije. Metoda omogućuje paralelnu identifikaciju biljega na pojedinačnim stanicama kombinacijom protočne citometrije i masene spektrometrije izotopa teških metala. Žene s različitim stupnjevima cervikalnih lezija (n=250) bit će uključene i praćene kroz 2 godine. Masenom citometrijom će se testirati najreprezentativnijih 100 uzoraka, kao i stanične linije RVM i normalnih stanica. Dobiveni podaci korelirat će se s promjenama cervikalnih lezija i promjenama u prisutnosti virusa kroz vrijeme. Obećavajući biljezi će se potvrditi imunocitokemijskim metodama na svim prikupljenim uzorcima. Pronalaženje biljega s visokom PPV otvorit će put za poboljšanje efikasnosti programa probira i time značajno ublažiti socioekonomski teret RVM a buduće pacijente poštedjeti prekomjernog rizika.]]></summary_hr><summary_en><![CDATA[Cervical cancer (CC) is the 4th cancer in women worldwide and even in Europe causing ~13,000 deaths annually. Although CC screening and human papillomavirus (HPV) vaccination offer significant protection, each has specific issues. Vaccination is ineffective if administered after HPV exposure, and even if offered according to recommendations, it does not protect against all HPV types causing CC. CC screening programmes, depending on the method used, cytology or HPV testing, have either reduced sensitivity or specificity, respectively, but still have high negative predictive values and effectively reduce mortality. Positive predictive value (PPV) for detecting women at high-risk of CC development, however, remains poor, making them less efficient since large number of women are referred to costly treatments that might not be needed. Besides costs, over-treating women, often of reproductive age, incurs treatment risks as well as complications in pregnancy including miscarriage. With this project, we aim to explore a panel of 30 potentially relevant cellular markers that are likely to correlate with disease course using state-of-the-art mass cytometry profiling. The method allows parallel identification of markers on single cells using a combination of flow cytometry and mass-spectrometry analysis of heavy metal isotope labels. Women with different stages of cervical lesions (n=250) will be enrolled and followed for up to 2 years. Mass cytometry will be done on best representative 100 patients as well as CC and normal cell lines. Resulting data will be correlated with cervical lesion and viral persistence changes. Potential biomarkers will be assessed by immunocytochemistry for validation on all collected samples. Finding biomarkers with high PPV will open the way for improving the efficacy of CC screening and thus significantly alleviate socioeconomic burden of CC as well as lessen the over-treatmetnt risks for future patients.]]></summary_en></project><project>
<id>8906</id><title_hr><![CDATA[Predviđanje ishodišnih stanica  i  istraživanje mehanizama razvoja raka bazirano na statističkom modeliranju]]></title_hr><title_en><![CDATA[A statistical modelling approach to predict the cell-of-origin and investigate mechanisms of cancer development]]></title_en><user_id>1188</user_id><user_firstLast_name>Rosa Karlić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-9308</code><acronim><![CDATA[PREDI-COO]]></acronim><duration>01.01.2020 - 31.08.2024</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>25665, 27132, 27193, 858372, </team_members_id><team_members_names><![CDATA[Pazi  Polak, Peter Arndt, Kirsten Kubler, Paula Štancl, ]]></team_members_names><keywords_hr><![CDATA[genomika, rak, statističko modeliranje, kromatin, mutacije]]></keywords_hr><keywords_en><![CDATA[Genomics, cancer, statistical modelling, chromatin, mutations]]></keywords_en><summary_hr><![CDATA[Raspodjela epigenetskih značajki ishodišne stanice i raspodjele mutacija u stanicama raka su međusobno ovisne, a utvrđeno je da je ta međuovisnost tkivno specifičan fenomen. U našem prethodnom radu smo iskoristili ovu činjenicu za razvoj jednostavne metode na temelju koje je sa velikom sigurnošću moguće predvidjeti ishodišno tkivo u kojem je rak nastao. Cilj ovog projekta je unapređenje prethodno razvijene metode određivanja ishodišnih stanica tumora korištenjem statističkih metoda i metoda strojnog učenja. Razviti će se i testirati metoda određivanja ishodišnih stanica tumora podacima dobivenim sekvenciranjem eksoma, te će se identificirati regije u genomu i epigenetske značajke koje su najinformativnije za određivanje ishodišnih stanica tumora. Nadalje, analizirati će se modeli trenirani na individualnim pacijentima te će se utvrditi minimalan broj mutacija i minimalna točnost modela potrebna za uspješno određivanje ishodišnih stanica tumora. Konačno, istražiti ćemo dovodi li uključivanje podataka o trodimenzionalnoj organizaciji kromatina do poboljšanja točnosti predviđanja ishodišnih stanica raka. Statistička analiza provedena u sklopu ovog projekta može dovesti do novih saznanja o staničnim procesima koji povezuju modifikacije histona i nastanak mutacija u raku, pomoći u istraživanju mehanizama nastanka različitih tipova raka i točnijeg određivanja gena koji sadrže takozvane „pogonske“ (driver) mutacije te omogućiti budući napredak u dijagnozi i tretmanu malignih bolesti.]]></summary_hr><summary_en><![CDATA[The distribution of epigenetic features of the cell-of-origin and the distribution of mutations in cancer cells are mutually dependent, and it is established that this interdependence is a tissue-specific phenomenon. In our previous work, we have used this fact to develop a simple method to predict the cell-of-origin of cancer with high accuracy.The aim of this project is to improve the previously developed method of determining the cancer cell-of-origin using statistical and machine learning methods. We will develop and validate a method of cell-of-origin prediction based on exome sequencing data and identify the most informative genomic regions and epigenetic features for prediction of the cell-of-origin. Furthermore, we will analyse models trained on individual patients and determine the minimum number of mutations and minimum accuracy of the model required for successful determination of cancer cell-of-origin. Finally, we will investigate whether the addition of information on the three-dimensional chromatin organization  will improve the prediction accuracy of the original model used for cell-of-origin prediction.The statistical analysis carried out within this project can lead to new findings about the cellular processes that link histone modifications and cancer mutations, help in the investigation of the mechanisms of development of different types of cancer and determination of genes that contain so-called &#39;&#39;driver&#39;&#39; mutations, and lead to further improvements in diagnosis and treatment of malignant diseases.]]></summary_en></project><project>
<id>8908</id><title_hr><![CDATA[Nesigurnost modeliranja odziva broda na valovima Jadranskog mora]]></title_hr><title_en><![CDATA[Modelling Uncertainty of Ship Wave-Induced Response  in the Adriatic Sea]]></title_en><user_id>810</user_id><user_firstLast_name>Joško Parunov</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-2085</code><acronim><![CDATA[MODUS]]></acronim><duration>01.01.2020 - 31.05.2024</duration><status>Završio</status><financ_value>113.876,17 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Brodogradnja, Tehnologija prometa i transport, </scie_field_hr><scie_field_en>Naval architecture, Transport technology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>17869, 26962, 26921, 26277, 6209, 861728, 17787, </team_members_id><team_members_names><![CDATA[Marko Katalinic, Antonio Mukilić, Petar Matić, Srđan Vujičić, Maro Ćorak, Tamara Petranović, Ivana Gledić, ]]></team_members_names><keywords_hr><![CDATA[valovi, brod, Jadransko more, mjerenja u naravi, nesigurnost modeliranja, umjetna inteligencija]]></keywords_hr><keywords_en><![CDATA[waves, ship, Adriatic Sea, full scale measurements, modelling uncertainty, artificial inteligence]]></keywords_en><summary_hr><![CDATA[U projektu se analiziraju dvije ključne nesigurnosti modeliranja  odziva broda na uzburkanom moru, tj. nesigurnost u modeliranju valova i nesigurnosti numeričkih proračuna pomorstvenosti broda. Svrha projekta je poboljšati razumijevanje i kvantificirati nesigurnosti modeliranja u predviđanju kratkoročnih i dugoročnih odziva broda. Nesigurnosti modeliranja koriste se u raznim problemima temeljenim na metodama pouzdanosti i rizika, kao što su analiza operabilnosti broda i optimiranje plovidbenih ruta, odlučivanje pri manevriranju broda u  nepovoljnim vremenskim prilikama i projektiranje brodske konstrukcije na osnovama metoda pouzdanosti. Projektom se određuju nesigurnosti odziva broda na valovima Jadranskog mora, iako se primijenjene metode i dobiveni rezultati mogu generalizirati i na druge akvatorije. Glavne aktivnosti u projektu su mjerenja u naravi, numerički proračuni  korištenjem metoda pomorstvenosti i primjena umjetne inteligencije za predviđanje odziva broda. Praktična primjena rezultata će se prikazati kroz analizu operabilnosti broda u Jadranskom moru,  temeljenu na metodama rizika.]]></summary_hr><summary_en><![CDATA[The project deals with two crucial types of the modelling uncertainties in predicting ship response in stochastic seaway, namely uncertainty in modelling wave data and uncertainty in theoretical seakeeping computations. The project is intended to improve understanding and quantification of modelling uncertainties in prediction of short- and long-term stochastic responses of ship in a seaway that may have different practical applications. Quantified uncertainties are typically used in ship reliability- and risk-based analyses as operability analysis and weather routing, heavy weather manoeuvring, risk-based ship operation and reliability-based ship structural design. The project covers description of the wave environment in the Adriatic Sea, although methods and obtained results may be generalized to other wave environments. Main activities in the project consist of full-scale measurements, numerical computations using standard seakeeping tools and application of artificial intelligence for ship response prediction. Practical application of results to the risk-based  ship operability analysis in the Adriatic Sea will be demonstrated. ]]></summary_en></project><project>
<id>8912</id><title_hr><![CDATA[Hrvatska rukopisna kultura: djela, pisari, zbirke]]></title_hr><title_en><![CDATA[Croatian Manuscript Culture: Works, Scribes, Collections]]></title_en><user_id>5337</user_id><user_firstLast_name>Irena Bratičević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-8566</code><acronim><![CDATA[HeRKUL]]></acronim><duration>01.01.2020 - 31.12.2023</duration><status>Završio</status><financ_value>51.150,71 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filologija, </scie_field_hr><scie_field_en>Philology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>4025, 769, 7383, 27007, 7050, 5024, 865254, </team_members_id><team_members_names><![CDATA[Tamara Tvrtković, Bojana Schubert , Luka Špoljarić, Ivan Lupić, Vladimir Rezar, Bratislav Lučin, Leon Cvitić, ]]></team_members_names><keywords_hr><![CDATA[rukopis, znanost o rukopisima, pisar, kolekcionarstvo, ranonovovjekovlje, hrvatska kultura]]></keywords_hr><keywords_en><![CDATA[manuscript, manuscript studies, scribe, collecting, early modern period, Croatian culture]]></keywords_en><summary_hr><![CDATA[Važnost ovog istraživanja leži u činjenici da je većina bogate hrvatske rukopisne književne baštine (procjenjujemo je na oko 10000 kodeksa) još uvijek neopisana i neproučena, dok je znanost o rukopisima, disciplina koja se u stranim filologijama formira posljednjih desetljeća, kod nas još u začecima te joj je potrebno postaviti teorijski okvir. Za proučavanje hrvatske rukopisne kulture odabrani su primjeri rukopisa i rukopisnih zbirki na temelju kojih će se iznijeti novi uvidi o materijalnim i nematerijalnim aspektima rukopisne kulture (fizičke značajke, postupak izrade rukopisa, suodnos autografa i prijepisa te tiskanih izdanja, djelovanje prepisivača, priređivača i kolekcionara, čitateljske prakse, promet rukopisa, predaja teksta itd.). Odabrani su rukopisi književnih djela na dvama najzastupljenijim jezicima, hrvatskom i latinskom, pokrivena sva razdoblja u rasponu od početka 15. do 2. pol. 19. stoljeća, kao i važnije kulturne sredine: dalmatinske komune, Dubrovnik i Zagreb s okolicom. Koristit ćemo se kodikološkom, paleografskom, tekstološkom, lingvističkom, književnom, historiografskom i kulturnopovijesnom metodologijom. Cilj je projekta ne samo dopuniti spoznaje o našoj rukopisnoj kulturi nego i koncipirati suvremeni teorijski pristup rukopisnoj građi te otvoriti put daljnjim istraživanjima. Planiramo izraditi kodikološki opis 15 rukopisa i 8 rukopisnih zbirki; proučiti povijesnu i usustaviti suvremenu kodikološku terminologiju te izraditi njezin pojmovnik; sastaviti registar domaćih i inozemnih zbirki s našim rukopisima, s popisom pripadajućih kataloga; rukopise prikazati na web-stranici; pripremiti 4 kritička izdanja; kompleksnosti i specifičnosti hrvatske rukopisne kulture predstaviti na međunarodnoj znanstvenoj sceni. Očekivani rezultati uključuju monografije, izvorne i pregledne znanstvene članke (od kojih neke u uglednim inozemnim časopisima), edukativne prezentacije, radionice, znanstveni skup, izlaganja rezultata na domaćim i inozemnim skupovima.]]></summary_hr><summary_en><![CDATA[The importance of this research lies with the fact that the majority of the manuscript literary heritage of Croatia (estimated at around 10,000 codices) has still not been studied and properly described. Manuscript studies, a discipline which has achieved prominence in the international scholarship in the last decades, is still taking shape in Croatia, lacking a proper theoretical and terminological framework. The research will be based on the manuscripts that can offer new insights into the material and nonmaterial aspects of the Croatian manuscript culture: physical aspects of manuscripts; process of making manuscripts; interrelationship between an autograph, a copy and a printed edition; scribal and editorial work, collectors; reading practices; circulation of manuscripts; transmission of the text etc. The research will cover manuscripts of literary works composed in Croatian and Latin, in the period between the early 15th and late 19th centuries, in the the Dalmatian cities, Dubrovnik and Zagreb. We will use codicological, palaeographical, textological, linguistic, literary, historiographical and culture-historical methodologies. The goal of the project is to fill the gaps in knowledge of Croatian manuscript culture and to conceptualize a modern theoretical approach to the manuscript sources and thus lay a groundwork for further research. We plan to prepare codicological descriptions of 15 manuscripts and 8 manuscript collections; study the historical and systematize the modern codicological terminology, prepare a glossary of terms; arrange a registry of national and foreign collections of Croatian manuscripts; present the manuscripts at the project web-page; prepare four critical editions; present the complexities and specificities of Croatian manuscript culture to the international scholarship. The expected results include monographs, original scholarly articles and overviews, workshops, educational presentations, a scholarly conference and presentations.]]></summary_en></project><project>
<id>8913</id><title_hr><![CDATA[Relativna promjena morske razine i klimatske promjene  duž istočne obale Jadrana ]]></title_hr><title_en><![CDATA[Relative sea level change and climate change along the  eastern Adriatic coast]]></title_en><user_id>3367</user_id><user_firstLast_name>Sanja Faivre</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-9445</code><acronim><![CDATA[SEALeveL]]></acronim><duration>31.01.2020 - 30.06.2024</duration><status>Završio</status><financ_value>132.425,51 eur</financ_value><scie_area_hr>Interdisciplinarno područje znanosti</scie_area_hr><scie_area_en>Interdisciplinary scientific area</scie_area_en><scie_field_hr>Geografija, </scie_field_hr><scie_field_en>Geography, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>3702, 3097, 10992, 1159, 3358, 27026, 27027, 27028, 23995, </team_members_id><team_members_names><![CDATA[Tatjana Bakran-Petricioli, Nina Lončar, Bogdan P. Onac, Jadranka Barešić, Davor Horvatic, Petra Kovač Konrad, Blaž Miklavič, Marin Mićunović, Marko Baričević, ]]></team_members_names><keywords_hr><![CDATA[promjena morske razine, klimatske promjene, algni vijenci, sige s fretskim obraštajem, obalna geomorfologija]]></keywords_hr><keywords_en><![CDATA[relative sea-level change, climate change, algal rim, phreatic overgrowths on speleothems, coastal geomorphology]]></keywords_en><summary_hr><![CDATA[Cilj predloženog projekt je istraživanje relativne promjene morske razine i klimatskih promjena duž istočne jadranske obale pomoću dva glavna markera algnih vijenaca i siga s fretaskim obraštajem. Algni vijenci koje gradi alga Lithophyllum byssoides pokazali su se dobrim indikatorom nekadašnje morske razine kod mikroplimnih obala, jer alge mogu živjeti samo u zoni plime i oseke te stoga predstavljaju najvišu biogenu konstrukciju u Mediteranu. Sige s freatskim obraštajem vrlo su rijetka pojava u špiljama obalnih područja gdje je razina podzemne vode određena morskom razinom. Formiranje freatskog obraštaja u uskoj zoni fluktuacije podzemne vode uzrokovane plimom i osekom te mogućnost preciznog određivanja njegove starosti čini ga izvrsnim indikatorom morske razine. Osim toga, špiljsko okružje u kojem nastaje štiti ga od erozije koja osigurava njegovo dugotrajno očuvanje. Oba markera, algni vijenci i sige s fretaskim obraštajem omogućuju određivanje indeksnih točaka promjene korištenih za konstruiranje krivulja relativne morske razine. Tako dobivene indeksne točke promjene povezati će se potom s fazama brzih klimatskih promjena na temelju analiza stabilnih izotopa dobivenih iz algnih vijenaca. Krivulje relativne promjene morske razine kvantificirati će se pomoću modela integriranog Gaussovog procesa s poznatom greškom varijabli (EIV-IGP). Krivulje relativne morske razine iz različitih dijelova Jadrana zajedno s podacima stabilnih izotopa iz alga predstavljati će osnovu za razumijevanje uzroka promjena: klimatske promjene, izostatički pomaci i tektonika. Istraživanje i razumijevanje kako i zašto se morska razina mijenjala u prošlosti omogućit će bolje procjene budućih promjena i procjene ranjivosti obalnih područja što može pomoći boljoj organizaciji i pripremi lokalne zajednice.]]></summary_hr><summary_en><![CDATA[The project aims to study the relative sea-level change and climate change along the eastern Adriatic coast by means of two principal sea-level indicators, algal rims and phreatic overgrowths on speleothems (POS). Rims of coralline rhodophyte Lithophyllum byssoides have proven to be a good proxy of past sea levels in microtidal environments because their living range is constrained around sea level. It thus creates the highest biogenic build-up in the Mediterranean. Phreatic overgrowths on speleothems (POS) are a rare occurrence in groundwater cave pools in coastal areas where groundwater level is controlled by sea level. Their formation in a narrow horizon within tide-induced groundwater fluctuation and the possibility of accurate dating makes POS an excellent sea-level indicator as well. In addition, the cave environment in which they occur protects them from erosion and thus ensures long-term preservation. Both, algal rims and POS allow the definition of sea-level index points (SLIP) used for the creation of relative sea-level curves. Obtained SLIPs from algal rims will be further related the periods of rapid climate changes by means of stable isotopes. The RSL changes will be quantified using an Error-In-Variables Integrated Gaussian Process (EIV-IGP) model. The relative sea-level curves from different parts of the eastern Adriatic coast together with stable isotope curves will represent the base for the understanding of driving mechanisms: climate changes, isostatic movements and tectonics. The study and understanding of relative sea-level changes in the past will allow better predictions of future changes and vulnerability estimation allowing community resilience to climate change.]]></summary_en></project><project>
<id>8925</id><title_hr><![CDATA[Nutritivna i funkcionalna vrijednost koprive (Urtica dioica L.) primjenom suvremenih hidroponskih tehnika uzgoja]]></title_hr><title_en><![CDATA[Nutritional and functional value of nettle (Urtica dioica L.) by application of modern hydroponic cultivation techniques]]></title_en><user_id>19151</user_id><user_firstLast_name>Sandra  Voća</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-3325</code><acronim><![CDATA[URTICA-BioFuture]]></acronim><duration>15.01.2020 - 14.01.2024</duration><status>Završio</status><financ_value>187.325,10 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Agronomski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Agriculture]]></institution_en><team_members_id>19134, 19358, 19844, 4953, 6184, 23516, 23403, 25247, 27115, 20422, 5708, 26941, 26953, 26954, 26957, 19768, 13477, 856289, 865271, </team_members_id><team_members_names><![CDATA[Jana Šic Žlabur, Ante Galić, Nadica Dobričević, Marko Petek, Marinko Petrović, Sanja Radman, Božidar Benko, Nina Toth, Zdenko Mlinar, Lepomir Čoga, Ivanka Žutić, Ivica Dodig, Davor Cafuta, Ivan Cesar, Brigitta Cafuta, Stjepan Pliestić, Sanja Fabek Uher, Nevena Opačić, Mia Dujmović, ]]></team_members_names><keywords_hr><![CDATA[kopriva, hidroponski uzgoj, vodni stres, specijalizirani metaboliti, antioksidacijska aktivnost ]]></keywords_hr><keywords_en><![CDATA[nettle, hydroponic cultivation, drought stress, specialized metabolites, antioxidant activity]]></keywords_en><summary_hr><![CDATA[Kopriva je višegodišnja biljka bogata fitokemikalijama i specijaliziranim metabolitima (SM), što ju svrstava u kategoriju biljaka velikog potencijala i široke primjene. Iako raste samoniklo u prirodi, teži se njenoj kultivaciji u svrhu dobivanja gotovog proizvoda ujednačenog kemijskog sastava. Odabranim agrotehničkim mjerama tijekom fenofaza u razvoju biljke značajno se može utjecati na sintezu i akumulaciju SM, koji su pod izravnim utjecajem brojnih biotskih, abiotskih i antropogenih čimbenika. Ključni čimbenici za dobivanje nutritivno kvalitetnog proizvoda adekvatnog prinosa uključuju balansiranu gnojidbu, fenofazu razvoja i dinamiku košnje. Sve evidentnije klimatske promjene potenciraju implementaciju suvremenih metoda uzgoja. Suvremene tehnike proizvodnje povrća podrazumijevaju hidroponski uzgoj koji pokazuje niz prednosti: dobro gospodarenje prirodnim resursima, racionaliziranu potrošnju vode zbog recirkulacije hranive otopine, sprječavanje gubitka hraniva iz rizosfere, kontrolu abiotskih čimbenika hranive otopine te zraka. Prilikom plasmana proizvoda na tržište, a u svrhu što duljeg očuvanja nutritivnih i organoleptičkih kvaliteta te trajnosti proizvoda, nužno je pakiranje istog s ciljem smanjenja kontakta svježe koprive s atmosferom okoliša. Ključni čimbenici prilikom pakiranja su odabir adekvatnog ambalažnog materijala i sastav plinova u pakiranjima. Pakiranje u modificiranoj atmosferi značajno usporava degradaciju nutritivnih svojstva svježe ubrane biljke uz osiguravanje mikrobiološke ispravnosti pakiranog proizvoda.]]></summary_hr><summary_en><![CDATA[Nettle is a perennial plant rich in phytochemicals and specialized metabolites (SM), often categorized as a product of great potential and wide usage. Although wild nettle is widespread in nature, its cultivation is necessary in order to achieve known chemical composition of final product. Agro-technical measures during different phases in plant&#39;s development can considerably impact the synthesis and accumulation of SM, which are directly influenced by numerous biotic, abiotic and anthropogenic factors. Key factors for obtaining a nutritive high quality product of adequate yield include balanced fertilization, plant development stage and harvest period. More evident climatic changes encourage the implementation of modern growing methods. Modern vegetables growing methods include hydroponic cultivation which shows number of advantages: good natural resources management, rationalized water consumption because of nutrient solution recirculation, preventing loss of nutrients from the rhizosphere, control of abiotic factors of nutrient solution and air. During the product market placement with an aim of longer nutritive and organoleptic qualities preservation and durability of the product it is necessary to pack the product with a goal to reduce the contact of fresh nettle with the surrounding atmosphere. Key factors during packaging are selection of adequate packaging material and gases composition in package. Packaging in a modified atmosphere significantly reduces the degradation of nutritional properties of fresh plant material while ensuring the microbiological safe of the packaged product.]]></summary_en></project><project>
<id>8926</id><title_hr><![CDATA[Model slobodnog odlučivanja o karijeri:  Uloga autonomne karijerne motivacije te zaštitnih i rizičnih faktora u profesionalnom razvoju adolescenata]]></title_hr><title_en><![CDATA[The Model of Free Career Choice:  The Role of Autonomous Career Motivation and Protective and Risk Factors in Career Development of Adolescents]]></title_en><user_id>1178</user_id><user_firstLast_name>Iva Šverko</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-7537</code><acronim><![CDATA[FreeCareerChoice]]></acronim><duration>01.01.2020 - 31.05.2025</duration><status>Završio</status><financ_value>71.805,69 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Psihologija, </scie_field_hr><scie_field_en>Psychology, </scie_field_en><institution_hr><![CDATA[Institut društvenih znanosti Ivo Pilar]]></institution_hr><institution_en><![CDATA[Institute of Social Sciences Ivo Pilar in Zagreb]]></institution_en><team_members_id>6293, 67, 27050, 27131, 5745, 6505, 19865, 21398, 21321, 861524, 865054, </team_members_id><team_members_names><![CDATA[Toni Babarović, Ljiljana Kaliterna Lipovčan, Terence  Tracey, Bart Wille, Maša Tonković Grabovac, Ivan Dević, Iva Černja, Mirta Blažev, Mara Šimunović, Dora Popović, Eta Krpanec, ]]></team_members_names><keywords_hr><![CDATA[Razvoj karijere, Model slobodnog odlučivanja o karijeri, autonomna karijerna motivacija, zaštitni i rizični faktori u karijeri, Put karijere]]></keywords_hr><keywords_en><![CDATA[Career development, Model of Free Career Choice, autonomous career motivation, protective and risk factors in career, The Career Path]]></keywords_en><summary_hr><![CDATA[Projekt FreeCareerChoice usmjeren je ispitivanju procesa odlučivanja o karijeri tijekom adolescencije. Teorije izbora i razvoja karijere uglavnom se ne bave širokim spektrom zaštitnih i rizičnih faktora koji djeluju na slobodu izbora zanimanja, niti se posvećuju motivacijskim procesima koji pokreću mlade ljude na odlučivanje o svom zanimanju. U okviru ovog projekta predlažemo Model slobodnog odlučivanja o karijeri u kojem naglašavamo ulogu zaštitnih i rizičnih faktora te autonomne karijerne motivacije u profesionalnom razvoju adolescenata. Smatramo da zaštitni i rizični faktori i autonomna karijerna motivacija, uz profesionalnu zrelost, djeluju na kvalitetu odabira karijere i posljedično na profesionalne ishode. U istraživanju će sudjelovati učenici osnovnih i srednjih škola dobi od 11 do 19 godina. Tri temeljna istraživačka cilja su (1) operacionalizacija konstrukta autonomne karijerne motivacije, (2) provjera uloge autonomne karijerne motivacije te zaštitnih i rizičnih faktora u modelu slobodnog odlučivanja u karijeri te (3) nadogradnja online sustava za profesionalno usmjeravanje Put karijere i evaluacija njegove učinkovitosti. Projekt uključuje tri nezavisna kvantitativna istraživanja (krossekcijsko i longitudinalno istraživanje te kvazieksperiment) te nekoliko manjih kvalitativnih studija. Rezultati istraživanja će osim znanstvenih publikacija i diseminacije uključivati i nadogradnju sustava za profesionalno usmjeravanje Put karijere koji će biti besplatan i javno dostupan svim korisnicima.]]></summary_hr><summary_en><![CDATA[The FreeCareerChoice project is focused on examining the career decision-making process during adolescence. Career theories largely do not deal with a wide range of protective and risk factors that can affect freedom of career choice and development, nor with motivational processes underlying career decisions of adolescents. Within this project we propose the Model of Free Career Choice, in which we emphasize the role of protective and risk factors and autonomous career motivation in the career development of adolescents. We believe that protective and risk factors and autonomous career motivation, along with career maturity, affect the quality of career choice and consequently related career outcomes. Primary and secondary school students from 11 to 19 years of age will participate in the research. The three fundamental research goals are (1) to operationalize the construct of autonomous career motivation, (2) to examine the role of autonomous career motivation and protective and risk factors in the Model of Free Career Choice, and (3) to upgrade the online career guidance system for students and evaluate its effectiveness. The project involves three independent quantitative studies (cross-sectional and longitudinal study and quasi-experiment) and several smaller qualitative studies. The research results will include, in addition to scientific publications and dissemination, the upgrading of the career guidance system The Career Path that will be free and publicly accessible to all users.]]></summary_en></project><project>
<id>8929</id><title_hr><![CDATA[Orkestracija hibridnih metoda umjetne inteligencije za računalne igre]]></title_hr><title_en><![CDATA[Orchestration of Hybrid Artificial Intelligence methods for computer Games]]></title_en><user_id>891</user_id><user_firstLast_name>Markus Schatten</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-5824</code><acronim><![CDATA[O-HAI 4 Games]]></acronim><duration>01.02.2020 - 30.04.2024</duration><status>Završio</status><financ_value>69.639,66 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Informacijske znanosti, Edukacijsko-rehabilitacijske znanosti, Interdisciplinarne društvene znanosti, </scie_field_hr><scie_field_en>Information sciences, Physical education and rehabilitation sciences, Interdisciplinary social sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet organizacije i informatike]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Organization and Informatics]]></institution_en><team_members_id>12678, 17828, 27043, 27052, 2508, 27048, 27103, 27023, 858355, </team_members_id><team_members_names><![CDATA[Neven Vrček, Bogdan Okreša Đurić, Damir Horvat, Vicente Julian Julian, Igor Tomičić, Jaime Andres Rincon Arango, Carlos Carrascosa, Smith Glenn, Tomislav Peharda, ]]></team_members_names><keywords_hr><![CDATA[umjetna inteligencija, višeagentni sustavi, računalne igre, hibridne metode, ansambl metoda, hologramske igre]]></keywords_hr><keywords_en><![CDATA[artificial intelligence, multi-agent systems, computer games, hybrid methods, ensemble of methods, holographic games]]></keywords_en><summary_hr><![CDATA[Hibridne metode umjetne inteligencije koje predstavljaju uspostavu ansambla različitih simboličkih i statističkih metoda umjetne inteligencije radi postizanja što točnijeg rezultata, sveprisutne su u stručnoj i znanstvenoj literaturi. Ipak, metodologija razvoja takvih metoda uglavnom je ad-hoc i ovisi od projekta do projekta. Računalne igre od samih su početaka vezane uz područje umjetne inteligencije - od Shannonovog minmax algoritma za umjetnog igrača šaha 1949., do najnovijih postignuća poput AlphaGo sustava koji je pobijedio velemajstora u igri Go, igre su se pokazale kao izrazito plodno područje za razvijanje metoda umjetne inteligencije. S druge strane umjetna je inteligencija izrazito važna komponenta većine računalnih igara koje se često vrednuju i hvale korištenjem novih i inovativnih metoda umjetne inteligencije. Računalne igre omogućuju nam provjeru metoda umjetne inteligencije ne samo u svrhu zabave, već i u mnogim drugim područjima ljudskog djelovanja, o čemu svjedoče područja ozbiljnih igara i igrifikacije. U projektnoj prijavi predlaže se uspostavljanje novog okvira za orkestraciju hibridnih metoda umjetne inteligencije s posebnom primjenom na razvoj računalnih igara. U skladu s time razvila bi se ontologija i meta-model alata za stvaranje modela (ansambla) metoda umjetne inteligencije, razvila modularna distribuirana platforma za orkestraciju hibridnih metoda umjetne inteligencije te razvio niz modula hibridnih ansambla koji bi se testirala u četiri okružja računalnih igara: (1) MMORPG igre, (2) igrificirana okolina za učenje, (3) ozbiljna igra vezana uz autonomna vozila i (4) igra za holografsku/volumetrijsku igraću konzolu koja bi se također razvila u projektu.]]></summary_hr><summary_en><![CDATA[Hybrid artificial intelligence methods, which can be defined as the orchestration of complementary heterogeneous both symbolic and statistical AI methods to acquire more precise results, are omnipresent in contemporary scientific literature. Still, the methodology of developing such systems is in most cases ad-hoc and depends from project to project. Computer games have always been connected to the development of AI. From the earliest chess minmax algorithm by Claude Shannon in 1949 to the more recent AlphaGo in 2015, computer games provide an ideal testing environment for AI methods. Similarly, AI has always been an important part of computer games, which have often been judged by the quality of their AI and praised if they used an innovative approach. Computer games allow us to test AI methods, not only for fun and leisure, but also for numerous other fields of human activity through the fields of serious games and gamification. The project proposes to establish an new framework for the orchestration of hybrid artificial intelligence methods with a special application to computer games. Therefore an ontology of hybrid AI methods as well as a meta-model shall be developed that would allow for creating models (ensembles) of hybrid AI methods. This meta-model would be implemented into a modular distributed orchestration platform which would be further enriched with a number of modules to be tested in four gaming related environments: (1) MMORPG games, (2) gamified learning platform, (3) serious game related to autonomous vehicles and (4) a game for a holographic/volumetric gaming console which would also be developed during the projedt.]]></summary_en></project><project>
<id>8932</id><title_hr><![CDATA[Razotkrivanje strukture hadrona pomoću tvrdih ekskluzivnih procesa]]></title_hr><title_en><![CDATA[Revealing the hadron structure through hard exclusive processes]]></title_en><user_id>5888</user_id><user_firstLast_name>Kornelija Passek-Kumerički</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-9709</code><acronim><![CDATA[REVESTRUCTURE]]></acronim><duration>01.02.2020 - 31.07.2024</duration><status>Završio</status><financ_value>115.269,76 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>5180, 335, 26506, 863811, 867414, 867606, </team_members_id><team_members_names><![CDATA[Goran Duplančić, Krešimir Kumerički, Lech Szymanowski, Nikola Crnković, Raj Kishore, Muhammad Saad Nabeebaccus, ]]></team_members_names><keywords_hr><![CDATA[teorijska fizika visokih energija, QCD, struktura hadrona, tvrdi ekskluzivni procesi, perturbativni račun, generalizirane partonske distribucije]]></keywords_hr><keywords_en><![CDATA[theoretical high-energy physics, QCD, hadron structure, hard exclusive processes, perturbative calculation, generalized parton distributions]]></keywords_en><summary_hr><![CDATA[Nukleoni (protoni i neutroni koji su građevni blokovi materije koja nas okružuje), pioni, kaoni i drugi hadroni sastoje se od kvarkova i gluona, čije su interakcije dobro opisane teorijom jakih interakcija, tj. kvantnom kromodinamikom. No  sveobuhvatno razumijevanje dinamike vezanih stanja hadrona i njihove strukture je još uvijek neuhvatljivo i izazovno. Štoviše, u akceleratorima čestica istraživanja Standardnog modela (SM) i istraživanja fizike izvan SMa se provode uglavnom koristeći protone i rastuća  točnost tih mjerenja  zahtijeva  sve bolji opis  strukture hadrona. U projektu REVESTRUCTURE istražit ćemo strukturu hadrona proučavanjem tzv. tvrdih ekskluzivnih procesa. Budući da se ti procesi izvode pri visokim energijama gdje jaka sila postaje slaba, u opisu partonskih potprocesa se može koristiti perturbativni pristup, a faktorizacija visoko i nisko energijske dinamike omogućuje nam pristup opisu hadrona preko distribucijskih amplituda i generaliziranih partonskih distribucija. Ovi potonji objekti fenomenološki su posebno zahvalni jer potencijalno nude trodimenzionalnu (3D) sliku hadrona za razliku od 1D slike dobivene iz dobro poznatih partonskih distribucijskih funkcija koje se susreću u duboko neelastičnom raspršenju. Predloženo fenomenološko istraživanje je pravovremeno jer je u zadnje vrijeme eksperimentalna aktivnost vrlo živa: mnogo podataka je već dostupno ili se očekuje u bliskoj budućnosti od  JLab i COMPASS (CERN) grupa, a planirana su i nova postrojenja (EIC u SAD-u, LHeC u CERN-u). Mi planiramo razviti odgovarajuće softverske alate, poboljšati teorijski opis izmjerenih procesa i analizirati nove procese koji bi se mogli mjeriti. Teorijske ćemo rezultate usporediti s dostupnim eksperimentalnim podacima i koristeći prilagodbe ćemo dobiti nove informacije o strukturi hadrona. A sve to bi trebalo omogućiti značajan korak k boljem razumijevanju hadrona.]]></summary_hr><summary_en><![CDATA[Nucleons, i.e., protons and neutrons that are the building blocks of the matter that surrounds us, pions, kaons and other hadrons consist of quarks and gluons, whose interactions are well described by the theory of strong interactions, i.e. quantum chromodynamics. But the comprehensive understanding of the bound state dynamic of hadrons and their structure is still elusive and challenging. Moreover, the experiments in particle accelerators used for Standard Model (SM) and beyond SM research are performed mostly using protons with ever higher accuracy demanding ever better description of hadron structure. In REVESTRUCTURE project we will investigate hadron structure by studying the, so-called, hard exclusive processes. Since these processes are performed at high energies where the strong force becomes weak the perturbative approach can be used in the description of the parton subprocesses and the factorization of the high and low energy dynamics enables us to access the hadron description of hadrons in terms of distribution amplitudes and generalized parton distributions. The latter objects are phenomenologically especially rewarding offering potentially a three-dimensional (3D) picture of hadrons in contrast to 1D obtained from well-known parton distribution amplitudes encountered in deeply inelastic scattering. Proposed phenomenological investigation is timely due to a recent vibrant experimental activity: a lot of data is already available or expected in the near future from JLab and COMPASS (CERN) groups, and new facilities are planned (EIC in USA, LHeC at CERN). We plan to develop the required software tools, to improve the theoretical description of the measured processes, and to analyze new processes to be measured in the future. We will confront the theoretical results with the available experimental data and through fits we will extract new informations about hadron structure. All this should make a significant step towards better understanding of hadrons.]]></summary_en></project><project>
<id>8933</id><title_hr><![CDATA[Operatori pomaka, statistički zakoni i beskonačno-dimenzionalni dinamički sustavi]]></title_hr><title_en><![CDATA[Transfer operators, statistical laws and infinite dimensional dynamical systems]]></title_en><user_id>2929</user_id><user_firstLast_name>Davor  Dragičević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-1239</code><acronim><![CDATA[TOSLDS]]></acronim><duration>01.01.2020 - 31.12.2023</duration><status>Završio</status><financ_value>98.480,32 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Fakultet za matematiku]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Mathematics]]></institution_en><team_members_id>793, 1027, 26449, 864894, </team_members_id><team_members_names><![CDATA[Danijel Krizmanić, Bojan Crnković, Mila Zovko, Lokesh singh singh, ]]></team_members_names><keywords_hr><![CDATA[operatori pomaka, granični zakoni, hiperbolična dinamika, linearizacija, algoritmi pretraživanja]]></keywords_hr><keywords_en><![CDATA[transfer operators, limit laws, hyperbolic dynamics, linearization, search algorithms ]]></keywords_en><summary_hr><![CDATA[Glavni cilj ovog projekta je ostvariti značajne doprinose u nekoliko različitih područja suvremene teorije dinamičkih sustava, kao i u usko povezanim područjima poput teorije vjerojatnosti i numeričke matematike. Problemi s kojima se planiramo baviti su teorijske i primijenjene prirode te su značajni ne samo za naša područja stručnosti, već i za druge discipline poput statističke fizike, matematičke statistike, teorije kontrole i inženjerstva.    Naše istraživačke aktivnosti će se fokusirati na unapređenju i daljnjem razvoju nedavnih važnih rezultata članova našeg tima, koji su objavaljeni u vodećim međunarodnim časopisima. Naglašavamo da je tijekom razdoblja 2014.-2019. naš tim publicirao 19 Q1 i 19 Q2 članaka. Najnoviji rezultati uključuju: razne granične teoreme za slučajne dinamičke sustave, uključujući prvu verziju lokalnog centralnog graničnog teorema u ovom kontekstu (D. Dragičević); prve rezultate posvećene glatkoj linearizaciji neautonomnih hiperboličnih dinamičkih sustava (D. Dragičević); razne spektralne karakterizacije hiperboličnosti neautonomnih dinamičkih sustava (D. Dragičević); nove funkcionalne granične teoreme za slabo zavisne slučajne procese (D. Krizmanić); nove algoritme pretraživanja (B. Crnković).Osim znanstvenog napretka, naš je cilj nastaviti postojeće i inicirati nove produktivne suradnje s više vodećih međunarodnih sveučilišta i eminentnih stručnjaka u našim područjima istraživanja. To će ne samo  učiniti naš istraživački tim vidljivijim, nego će i poboljšati međunarodnu prepoznatljivost Odjela za matematiku Sveučilišta u Rijeci.Štoviše, zapošljavanjem jednog doktoranda i jednog postdoktoranda planiramo privući mlade perspektivne matematičare te im pružiti poticajno istraživačko okruženje i mogućnost rada pod vodstvom energičnih iskusnih istraživača. To će također doprinijeti jačanju našeg istraživačkog tima.]]></summary_hr><summary_en><![CDATA[The main objective of this project is to make significant contributions to several different areas of the modern dynamical systems theory as well as to closely related fields like probability theory and numerical mathematics.  The problems we plan to address are of both theoretical and applied nature and relevant not only to our fields of expertise but also for several other disciplines like statistical physics, mathematical statistics, control theory and engineering. Our research activities will focus on advancement and further development of recent important results of the team members, published in leading international journals. We emphasize that during the period from 2014-2019, our team has published 19 Q1 and 19 Q2 articles. The recent results include: Various limit theorems for random dynamical systems including the first version of the local central limit theorem in this setting (D. Dragičević); First results devoted to smooth linearization of nonautonomous hyperbolic dynamics (D. Dragičević); Various spectral characterizations of hyperbolicity for nonautonomous dynamics (D. Dragičević), New functional limit theorems for weakly dependent processes (D. Krizmanić); New search algorithms (B. Crnković). In addition to scientific advancement, our goal is to continue existing and initiate new productive collaborations with several leading international universities and eminent experts in our research fields. This will not only make our research group more visible but will also improve international recognizability of the Department of Mathematics, University of Rijeka. Moreover, by hiring one PhD student and one postdoctoral researcher, we plan to attract young perspective mathematicians and provide them with a stimulating research environment and an opportunity to work under the guidance of energetic senior researchers. This will also contribute towards strengthening of our research team.  ]]></summary_en></project><project>
<id>8935</id><title_hr><![CDATA[Histološki, klinički, laboratorijski i genski prediktori ishoda bolesnika s Henoch-Schönleinovom purpurom i nefritisom]]></title_hr><title_en><![CDATA[Histological, Clinical, Laboratory and Genetic Predictors of Outcome in Patients with Henoch-Schönlein Purpura and Nephritis]]></title_en><user_id>26821</user_id><user_firstLast_name>Marija Jelušić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-8822</code><acronim><![CDATA[PURPURAPREDICTORS]]></acronim><duration>10.01.2020 - 09.04.2024</duration><status>Završio</status><financ_value>132.656,45 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Clinical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>4155, 5028, 2695, 20465, 5638, 4711, 19435, 3891, 27192, 4550, 27037, 4540, 5341, 27191, 26368, 861735, 865258, </team_members_id><team_members_names><![CDATA[Marijana Ćorić, Danko Milošević, Gordana Laškarin, Alenka Gagro, Zorana Grubić, Stela Bulimbašić, Ana Kozmar, Kristina Crkvenac Gornik, Carola Vinuesa, Kristina Fišter, Saša Sršen, Aleksandar Ovuka, Katarina Štingl Janković, Nastasia Kifer, Mario Šestan, Martina Held, Matej Šapina Šapina, ]]></team_members_names><keywords_hr><![CDATA[Henoch-Schönleinova purpura, IgA vaskulitis, glomerulonefritis, biomarkeri, biopsija, histologija, djeca, tipizacija, polimorfizam, alarmini ]]></keywords_hr><keywords_en><![CDATA[Henoch-Schönlein purpura, IgA Vasculitis, Glomerulonephritis, Biomarkers, Biopsy, Histology, Children, HLA Typing, Polymorphism, Alarmins ]]></keywords_en><summary_hr><![CDATA[Ovaj je projekt fokusiran na Henoch-Schönleinovu purpuru (HSP), najčešći vaskulitis u dječjoj dobi. Iako se radi o bolesti koja je najčešće samoograničavajuća, do 60% djece s HSP-om razvije nefritis (HSPN) koji je gotovo jedini uzrok morbiditeta i mortaliteta, s vjerojatnošću razvoja kroničnog bubrežnog zatajenja u rasponu od 1 do 15%. Za potvrdu dijagnoze HSPN-a, odabir terapije i praćenje bolesnika važna je biopsija bubrega, no još uvijek ne postoji jedinstvena histološka klasifikacija. Biopsija bubrega invazivan je postupak s određenim komplikacijama te se ulažu veliki napori u iznalaženju manje invazivnih markera pomoću kojih bi se moglo predvidjeti koji će bolesnici razviti HSPN, imati lošiju prognozu i zahtijevati agresivnije postupke liječenja. U sklopu nacionalnog multicentričnog istraživanja u pet tercijarnih pedijatrijskih reumatoloških i nefroloških centara namjeravamo utvrditi primjenjivost imunoglobulina A1 bez galaktoze (Gd-IgA1), proteina visoke pokretljivosti iz skupine 1 (HMGB1), kalprotektina, protokadherina-1 i tiola pri predviđanju razvoja nefritisa, odnosno aktivnosti upale te u predviđanju trajanja bubrežne bolesti, utvrditi moguću povezanost polimorfizama gena HMGB1 i RAGE i razvoja HSPN-a, odrediti izražaj HMGB1 i stupanj infiltracije makrofaga u bubrežnom tkivu, identificirati alele HLA-DRB1 koji se javljaju s većom učestalošću u oboljelih u hrvatskoj populaciji, odrediti primjenjivost sekvencioniranja cijelog egzoma u oboljelih, ispitati moguće genske mutacije koje imaju ulogu u etiopatogenezi te utvrditi koja od najčešće korištenih patohistoloških klasifikacija najbolje predviđa težinu i ishod bubrežne bolesti. Očekujemo da se analizom navedenih parametara koji ukazuju na produljeno trajanje autoimunosnog procesa i predstavljaju rani prediktor oštećenja funkcije bubrega, mogu izdvojiti bolesnici s nepovoljnim tijekom bolesti kako bi se u budućim istraživanjima pronašla strategija sprječavanja progresije u završni stadij bubrežne bolesti.]]></summary_hr><summary_en><![CDATA[This project is focused on Henoch-Schönlein&#39;s purpura (HSP), the most common vasculitis in childhood. Although the disease is most often self-limiting, up to 60% of children with HSP develop nephritis. Chronic renal failure has been reported in 1% to 15% patients, and is the major cause of mortality and morbidity among children suffering from HSP. The confirmation of diagnosis of HSPN requires a renal biopsy, that has an important role for therapy selection and patient monitoring, but still there is no single histological classification. Biopsy is an invasive procedure with certain complications, and great efforts are being made to find less invasive markers that could predict which patients would develop HSPN, have a poor prognosis and require more aggressive treatment procedures. In a national multi-centre research in 5 Croatian University Centers for pediatric rheumatology and nephrology we intend to establish the value of galactose-deficient IgA1, high-mobility group protein box 1 (HMGB1), calprotectin, protocadherin-1 and thiols in prediction of HSPN development, activity of inflammation and prediction of disease duration, establish possible associtation of HMGB1 and RAGE gene polymorphisms and HSPN development, determine the expression of HMGB1 and the degree of macrophage infiltration in renal tissue, identificate the HLA-DRB1 alleles with higher frequency in Croatian population of HSP/HSPN patients, determinate the feasibility of whole exome sequencing in patients with HSP and HSPN, explore possible rare variants involved in the etiopathogenesis and establish which of the most frequently used histological classifications most significantly predict severity and renal outcome. We expect that with the analysis of the mentioned parameters we will be able to early identificate HSP patients with unfavourable renal outcomes, that will guide more intensive clinical care and help design future research aiming to prevent progression to end-stage kidney disease.]]></summary_en></project><project>
<id>8938</id><title_hr><![CDATA[Modeliranje mreže prapovijesnih naselja u Slavoniji]]></title_hr><title_en><![CDATA[Modelling Prehistoric Networks of Slavonia]]></title_en><user_id>25165</user_id><user_firstLast_name>Rajna Šošić Klindžić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-5344</code><acronim><![CDATA[MOPRENS]]></acronim><duration>10.01.2020 - 09.01.2024</duration><status>Završio</status><financ_value>79.551,53 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Arheologija, </scie_field_hr><scie_field_en>Archeology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>3440, 7392, 3511, 21272, 26466, 19197, 22653, 19213, 27049, 856141, 866614, </team_members_id><team_members_names><![CDATA[Katarina Gerometta, Hrvoje Kalafatić, Koraljka Bakrač, Petra Rodik, Iza Romanowska, Jacqueline Balen, Dario Hruševar, Dragana Rajković, Boban Tripković, Goran Tomac, Petros Chatzimpaloglou, ]]></team_members_names><keywords_hr><![CDATA[Neolitik, Modeliranje bazirano na agentima, Mreža naselja, Društveni odnosi, Paleookoliš, Geoarheologija, Kronologija neolitika]]></keywords_hr><keywords_en><![CDATA[Neolithic, Agent-based modelling, Settlement Pattern, Social dynamics, Paleoenvironment, Geoarchaeology, Neolithic Chronology]]></keywords_en><summary_hr><![CDATA[Glavni cilj projekta je razumijevanje dinamike života u kasnom neolitiku Slavonije kroz računalne simulacije i izradu modela društvene dinamike. Za izgradnju modela koristit će se podaci prikupljeni terenskim i laboratorijskim istraživanjima u sklopu projekta, te rezultati prethodno provedenih istraživanja. Postojeći okvir arheoloških interpretacija oslanja se na teorijske modele i misaone koncepte posuđene iz drugih društvenih i humanističkih disciplina, a koji su formirani tijekom prve polovice 20. stoljeća te se kao takav pokazao nedostatnim za sveobuhvatno razumijevanje društvene dinamike u prošlosti. Paradigmatske promjene u arheologiji 21. stoljeća zahtijevaju nove teorije i objasnidbene modele za interpretaciju života u prošlosti. U sklopu projekta koristit će se modeliranje temeljno na agentima (ABM) jer daje rezultate koji odražavaju stohastičke procese, slično kao i povijest ljudskih aktivnosti te time nadilazi tradicionalna ograničenja analize i interpretacije prošlosti. Na ovom projektu bit će angažirani stručnjaci iz 4 znanstvena polja: arheologije, geologije, biologije i sociologije. Svaki od suradnika na projektu specijaliziran je za određenu istraživačku problematiku i analizu specifične vrste podataka: analizu materijalne kulture, analizu prostornih podataka, podatkovnu znanost, izgradnju  simulacijskih modela, proučavanje društvene dinamike, terenska istraživanja i zračna rekognosciranja, geološke i geoarheološke analize te analize faunskih i biljnih ostataka. Veliki i heterogeni skupovi podataka prikupljeni tijekom projekta će se analizirati i modelirati računalnim metodama kroz nove načine konceptualizacije, razine razmjera i detaljnosti u istraživanju društvenih promjena. Kroz primjenu ABM istraživat će se međusobni odnosi različitih varijabli u prostornom okruženju naseljenom agentima koji oponašaju društvene skupine u svrhu modeliranja mogućih uzroka i odrednica društvene dinamike i društvene promjene u neolitiku Slavonije.]]></summary_hr><summary_en><![CDATA[The main goal of the project is to understand the social dynamic in the late Neolithic Slavonia through computational simulations and the development of social and cultural relations and change models which will be built using data collected by field and laboratory research within the project, as well as the results of the previously conducted research.The existing framework of archaeological interpretations relies on theoretical models and concepts developed by other social and humanistic disciplines, formed during the first half of the 20th century and as such proved inadequate for a comprehensive understanding of social dynamics in the past. Paradigmatic changes in the 21st century archeology require new theories and explanatory models for the interpretation of life in the past.As part of the project, agent-based modelling (ABM) will be used, because it produces results that reflect stochastic complexity, similar to the history of human activities, thus exceeding the traditional limitations of interpretation and analysis of the past.This project will involve experts from 4 scientific fields: archaeology, geology, biology and sociology. Each of the team members is an expert in specific research issues and analysis of specific data sets: analysis of material culture, spatial data analysis, data science, agent-based modelling, social dynamics, field research and remote sensing, geological and geo-archaeological analysis, and analysis of fauna and plant residues. Large and heterogeneous data sets collected during the project will be analysed and modeled by computational methods through new ways of conceptualization, scale and resolution in social complexity and change research. Through the application of ABM, mutual relations of different variables in a spatial environment populated by agents that mimic social behavior will be investigated in order to build models of possible causes and reasons of social dynamics and social change in the Neolithic Slavonia.]]></summary_en></project><project>
<id>8939</id><title_hr><![CDATA[Od oblika do funkcije: Fleksibilni kristalni materijali s kontroliranim mehaničkim odzivom]]></title_hr><title_en><![CDATA[From form to function: Mechanically flexible crystalline materials with controllable responses]]></title_en><user_id>1229</user_id><user_firstLast_name>Marijana Đaković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-1242</code><acronim><![CDATA[FlexibleCrystals]]></acronim><duration>15.01.2020 - 14.07.2024</duration><status>Završio</status><financ_value>175.494,59 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>713, 4669, 4656, 17739, 23811, 1327, 23919, 3881, 26242, 858397, </team_members_id><team_members_names><![CDATA[Željka Soldin, Ivan Kodrin, Ivana Biljan, Mladen Borovina, Mateja Pisačić, Boris-Marko Kukovec, Marko Pužar, Christer Aakeroy, Simanhewa Lakshitha Viraj De Silva, Ozana Mišura, ]]></team_members_names><keywords_hr><![CDATA[kristali s mehaničkim odzivom, elastično savitljivi kristalni materijali, koordinacijski polimeri, kristalno inženjerstvo, nekovalentne interakcije]]></keywords_hr><keywords_en><![CDATA[mechanically responsive crystals, crystalline materials with elastic flexibility, coordination polymers, crystal engineering, non-covalent interaction]]></keywords_en><summary_hr><![CDATA[Mehanička savitljivost, iako osnovno svojstvo većine živih sustava, rijetko se pojavljuje kod kristalnih materijala. Kristalne krutine općenito su nesavitljive i lako pucaju i/ili se lome pri izlaganju mehaničkom podražaju, osobito ako su im građevne jedinke povezane međumolekulskim interakcijama usporedive jakosti u svim smjerovima. Međutim, nekoliko nedavno objavljenih znanstvenih radova opisuje savitljive organske kristale i svega nekoliko primjera 0-D metaloorganskih kristalnih krutina koje mogu pokazivati savitljivost pod utjecajem mehaničke sile. Prvi rad o mehanički savitljivim kristalnim 1-D koordinacijskim polimerima objavljen je 2018. godine. U tom radu smo pokazali da se stupanj elastičnosti može kontrolirati uvođenjem malih ali kontroliranih strukturnih promjena, a takvo nešto dosad još nije bilo poznato.S ciljem potpunog razumijevanja i objašnjenja uvjeta potrebnih za prilagodljivost i ugodivu savitljivost kristalnih koordinacijskih polimera pod utjecajem vanjskog mehaničkog podražaja, predlažemo kombinaciju teorije i eksperimenta za sustavno istraživanje specifičnih strukturnih značajki i međumolekulskih interakcija te njihovog utjecaja na mehanička svojstva kristalnih koordinacijskih polimera. Glavni je cilj ovog interdisciplinarnog istraživanja na granici kemije i znanosti o materijalima definirati postojane i prenosive smjernice za dizajn kristalnih koordinacijskih polimera s a priori određenom savitljivošću, na temelju ‘bottom-up’ pristupa. Takvi materijali imali bi najbolja svojstva meke i kristaline tvari – ugodivu pokretljivost i očuvanu uređenost dalekog dosega. Time bi pružili nove i jedinstvene mogućnosti znanosti o materijalima i inženjerstvu, jer navedeni koordinacijski polimeri omogućuju dosad nezamisliv uvid u novu generaciju pametnih materijala s ugodivom funkcijom.]]></summary_hr><summary_en><![CDATA[Mechanical flexibility, an essential characteristic of most living systems, is rare among crystalline materials. Crystalline solids are in general brittle, and they tend to crack and/or break upon application of mechanical stress, especially if they are held together by intermolecular bonds that are of comparable strength in all directions. Recently, however, there have been several publications describing flexible organic crystals, and a few cases of 0-D metal-organic crystalline solids that can respond flexibly to an applied mechanical force.  The very first paper on crystalline 1-D coordination polymers with mechanical flexibility was published in 2018, wherein we also demonstrated that the extent of elasticity could be controlled by introducing small and controllable structural modifications, something that had not been accomplished before. In order to fully understand and explain which conditions need to be met for crystalline coordination polymers to be adaptive and tunably flexible in response to external mechanical stimuli, we propose a combination of theory and experiment to systematically explore how specific structural features and intermolecular interactions impart mechanical properties in crystalline coordination polymers. The overarching goal of this interdisciplinary research effort at the interface of chemistry and materials science is to deliver robust and transferable guidelines for bottom-up design of coordination polymers with a priori determined flexibility.  Such materials would combine the best features of both soft and crystalline matter, by presenting tunable mobility whilst preserving a long-range order, and subsequently offer unique opportunities for materials science and engineering as they contain coordination polymers at their core, which can provide unprecedented access to a new generation of smart materials with tunable functionality.]]></summary_en></project><project>
<id>8946</id><title_hr><![CDATA[Miocenska sin-riftna evolucija Sjevernohrvatskog bazena (Karpatsko-Panonska regija): “multi-proxy” pristup, korelacija i integriranje sedimentnog i vulkanskog zapisa]]></title_hr><title_en><![CDATA[Miocene syn-rift evolution of the North Croatian Basin (Carpathian-Pannonian Region): a multi-proxy approach, correlation and integration of sedimentary and volcanic record]]></title_en><user_id>19153</user_id><user_firstLast_name>Mihovil Brlek</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2019-04</proposal_call><code>UIP-2019-04-7761</code><acronim><![CDATA[PYROSKA]]></acronim><duration>30.12.2019 - 29.06.2025</duration><status>Završio</status><financ_value>205.485,43 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Geologija, </scie_field_hr><scie_field_en>Geology, </scie_field_en><institution_hr><![CDATA[Hrvatski geološki institut]]></institution_hr><institution_en><![CDATA[Croatian Geological Survey]]></institution_en><team_members_id>19549, 13085, 26326, 3796, 22796, 26206, 26350, 26170, 855604, 865579, </team_members_id><team_members_names><![CDATA[Ivan Mišur, Vlatko Brčić, Viktória Baranyi, Duje Kukoč, Monika Milošević, Sanja Šuica, Simon Tapster, Belo Julie Christin, Nina Trinajstić, Sean Gaynor, ]]></team_members_names><keywords_hr><![CDATA[miocen, Sjevernohrvatski bazen, sin-rift, geokronologija, biostratigrafija, vulkanizam, Karpatsko-Panonska regija, Središnji Paratetis]]></keywords_hr><keywords_en><![CDATA[Miocene, North Croatian Basin, syn-rift, geochronology, biostratigraphy, volcanism, Carpathian-Pannonian Region, Central Paratethys]]></keywords_en><summary_hr><![CDATA[Vulkanogeno-sedimentni kompleksi Sjevernohrvatskog bazena (NCB) sadrže vrijedne informacije o evoluciji Karpatsko-Panonske regije (CPR, Alpsko-Karpatsko-Dinaridski orogenetski sustav) i Središnjeg Paratetisa. Međutim, mnoga su pitanja još uvijek otvorena. Projektni prijedlog PYROSKA okuplja desetoročlanu međunarodnu istraživačku grupu čiji je glavni cilj primjena najsuvremenijeg ”multi-proxy” pristupa u svrhu utočnjavanja miocenske sin-riftne evolucije NCB-a. Funkcionalna i referentna istraživačka grupa kombinirat će komplementarna znanja i vještine kako bi omogućila pouzdane rekonstrukcije i implementaciju projekta. Provođenje vremensko-stratigrafskih korelacija korištenjem integriranih biostratigrafskih i geokronoloških metoda visoke preciznosti omogućiti će određivanje točnog vremena početnog preplavljivanja NCB-a Središnjim Paratetisom. Tefrokronologija i rekonstrukcije vulkanske provenijencije piroklastita NCB-a zahtijevati će vulkanološke i petrološke odredbe, primjenu U-Pb i Ar/Ar geokronologije (EARTHTIME inicijativa), kao i mineraloške, geokemijske i izotopne analize. Stečeni podaci visoke rezolucije posljedično će omogućiti i pouzdanije regionalne rekonstrukcije, uključujući kalibraciju i sinkronizaciju ”bio-događaja” Središnjeg Paratetisa, kao i rekonstrukciju magmatske evolucije CPR-a. Karakteristični obrazac istraživačkih ciljeva (i povezanih aktivnosti) PYROSKA projekta biti će: Definiranje i uzorkovanje stratigrafskih stupova miocenskih vulkanogeno-sedimentnih kompleksa > Priprema uzoraka za analizu > Analiza uzoraka, obrada i interpretacija podataka. Originalna, te nacionalno i međunarodno značajna istraživačka ideja omogućiti će produciranje izvrsnih Q1/Q2 publikacija. Ostali rezultati PYROSKA projekta bit će: uspješan razvoj istraživačke karijere doktoranda, usavršavanje hrvatskih članova istraživačke grupe, kao i prijavljivanje novih kompetitivnih znanstvenih projekata od strane funkcionalne, referentne i opremljene PYROSKA istraživačke grupe.]]></summary_hr><summary_en><![CDATA[North Croatian Basin (NCB) volcano-sedimentary complexes hold valuable information concerning the evolution of the Carpathian-Pannonian Region (CPR, Alpine–Carpathian–Dinaridic orogenic system) and Central Paratethys. However, there are still many open questions. PYROSKA project proposal gathers an international 10-membered research group with the main goal of applying a state-of-the-art multi-proxy approach in refining Miocene NCB syn-rift evolution. In order to make reliable reconstructions and enable project implementation, the functional and referenced PYROSKA team will combine complementary expertise and skills. Timing of the initial Central Paratethys flooding of the NCB will be resolved by conducting time-stratigraphic correlations, that is by using integrated biostratigraphic and high-precision geochronological methods. Tephrochronology and volcanic provenance reconstructions of NCB pyroclastics will require volcanological and petrological determinations, U-Pb and Ar/Ar radiometric dating (EARTHTIME initiative), as well as mineralogical, geochemical and isotopic fingerprinting. Acquired high-resolution data will consequently enable more reliable regional reconstructions, including calibration and synchronization of Central Paratethys bioevents, as well as CPR magmatic evolution. Characteristic project pattern of research objectives (and associated activites) will be: Defining and sampling Miocene volcano-sedimentary stratigraphic sections > Sample preparation for the analysis > Sample analysis, data processing and interpretation. The research idea, being an original, nationally and internationally significant, will enable the production of excellent Q1/Q2 publications. PYROSKA project results will also include: successfull development of a doctoral student research career, supervised training of Croatian research group members, as well as application of new competitive scientific project by a functional, referenced and equipped PYROSKA research group.]]></summary_en></project><project>
<id>8955</id><title_hr><![CDATA[Dinamika reproduktivnog i seksualnog zdravlja mladih u Hrvatskoj od 2005. do 2020. godine]]></title_hr><title_en><![CDATA[Dynamics of Reproductive and Sexual Health in Emerging Croatian Adults, 2005—2020]]></title_en><user_id>5817</user_id><user_firstLast_name>Aleksandar Štulhofer</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-3609</code><acronim><![CDATA[SERZAM2020]]></acronim><duration>01.02.2020 - 31.01.2024</duration><status>Završio</status><financ_value>72.201,21 eur</financ_value><scie_area_hr>Društvene znanosti, Biomedicina i zdravstvo, </scie_area_hr><scie_area_en>Social sciences, Biomedicine and health sciences, </scie_area_en><scie_field_hr>Sociologija, Javno zdravstvo i zdravstvena zaštita, Psihologija, </scie_field_hr><scie_field_en>Sociology, Public health and health services, Psychology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>5502, 2729, 25866, 25946, 19564, 17799, 25828, 25843, 1087, 858445, </team_members_id><team_members_names><![CDATA[Ivan Landripet, Goran Milas, Ivana Božičević, Valerio Baćak, Tanja Jurin, Goran Koletić, Tatjana Nemeth Blažić, Mirjana Lana Kosanović Ličina, Azra Tafro, Sandra Sevic, ]]></team_members_names><keywords_hr><![CDATA[mladi, rizično ponašanje, reproduktivno i seksualnu zdravlje, religioznost, biobihevioralno istraživanje]]></keywords_hr><keywords_en><![CDATA[emerging adults, risk taking, reproductive and sexual health, religiosity, bio-behavioral study]]></keywords_en><summary_hr><![CDATA[Ovaj multidisciplinarni biobihevioralni projekt nastavlja se na dvije nacionalne studije seksualnog i reproduktivnog zdravlja mladih provedene 2005. i 2010. godine. Istraživanje ima dva cilja: (1) utvrditi trenutnu raširenost te vremensku dinamiku rizičnih seksualnih ponašanja u nacionalnoj populaciji mladih u dobi od 18 do 25 godina tijekom posljednjih 15 godina; (2) ispitati ulogu vjere i religioznosti kao zaštitnih čimbenika u kontekstu rizičnog seksualnog ponašanja. Drugi cilj projekta vezan je uz nepostojanje sustavne prevencije rizičnog seksualnog ponašanja među mladima te porast religioznosti u Hrvatskoj.Prikupljanje biobihevioralnih podataka provest će se na nacionalnom probabilističkom online panelu 1.200 osoba u dobi između 18 i 25 godina. Sve procedure u bihevioralnom dijelu studije razrađene su prema total survey error modelu. U biološkom dijelu istraživanja prikupit ćemo uzorke urina 400 slučajno odabranih seksualno aktivnih sudionika panela; informirani pristanak tražit će se odvojeno za bihevioralni i biološki dio istraživanja. Uzorke ćemo testirati na klamidijsku infekciju (kao u istraživanju iz 2010. godine) uporabom PCR metode. Jedinstveni numerički kodovi omogućit će povezivanje bioloških i bihevioralnih podataka. Svi sudionici biološkog dijela studije dobit će karticu s osobnom šifrom i uputom na koji način mogu saznati rezultat testiranja te, bude li potrebno, biti upućeni na liječenje.Očekujemo da će projektni uvidi pridonijeti razvoju empirijskim utemeljenih intervencija usmjerenih očuvanju reproduktivnog i seksualnog zdravlja mladih u Hrvatskoj.Konceptualni pristup koji koristimo za ispitivanje povezanosti između religioznosti i izloženosti seksualnim rizicima (testirajući četiri specifična mehanizma utjecaja) originalni je doprinos znanstvenoj literaturi – kako u razjašnjavanju kontradiktornih nalaza tako i unaprjeđivanjem spoznaja o odnosu između religioznosti i reproduktivnog te seksualnog zdravlja mladih.]]></summary_hr><summary_en><![CDATA[This multidisciplinary bio-behavioral research project builds upon two national probability-based surveys of reproductive and sexual health in emerging adults (18-25) carried out in 2005 and 2010. The project has two aims: (1) to describe and analyze the current prevalence of risky sexual behaviors, as well as its dynamics in the 2005-2020 period using repeated cross-sectional data; and (2) to provide a systematic assessment of the role of personal faith and religiosity in emerging adults’ sexual and reproductive health. The second aim is related to growing levels of religiosity among young people and the absence of comprehensive school-based sexuality education in Croatia.To collect data, we intend to use a national online panel of 1,200 individuals aged 18-25 years maintained by a local market research firm. All study procedures in the behavioral arm are specified according to the total survey error model. The biological arm of the study will include 400 urine samples to be tested for Chlamydia trachomatis (as in the 2010 study) from randomly sampled participants in the behavioral survey. Informed consent will be asked separately for the behavioral and biological parts of the study. Urine samples will be tested for Chlamydia trachomatis using PCR. All samples will be coded with a unique random-digit code to enable linking with behavioral data. Participants will receive a card containing a code and a phone number to learn about their result, receive post-test counseling and, if needed, be referred for treatment.The project will provide detailed and systematic insight into the dynamics of reproductive and sexual health in emerging adults to be used for evidence-based policy planning and specific public health interventions. In addition, our testing of four specific conceptual mechanisms hypothesized to underlie the association between religiosity and sexual risk taking is an original contribution to the literature currently characterized by ambivalent findings.]]></summary_en></project><project>
<id>8957</id><title_hr><![CDATA[Razvoj metodologije procjene podložnosti na klizanje za planiranje namjene zemljišta primjenom LiDAR tehnologije]]></title_hr><title_en><![CDATA[Methodology development for landslide susceptibility assessment for land-use planning based on LiDAR technology]]></title_en><user_id>27065</user_id><user_firstLast_name>Snježana Mihalić Arbanas</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-9900</code><acronim><![CDATA[LandSlidePlan]]></acronim><duration>01.01.2020 - 31.12.2023</duration><status>Završio</status><financ_value>76.178,91 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Rudarstvo, nafta i geološko inženjerstvo, Građevinarstvo, </scie_field_hr><scie_field_en>Mining, petroleum and geological engineering, Civil engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Rudarsko-geološko-naftni fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mining, Geology and Petroleum Engineering]]></institution_en><team_members_id>20171, 26766, 13520, 25805, 858322, 863816, 863815, 863812, 867492, </team_members_id><team_members_names><![CDATA[Željko Arbanas, Sanja Bernat Gazibara, Petra Đomlija, Martin Krkač, Marko Sinčić, Veronica Tofani, Nicola Casagli, Marko Komac, Hrvoje Lukačić, ]]></team_members_names><keywords_hr><![CDATA[klizišta, LiDAR, inventar klizišta, procjena podložnosti na klizanje, prostorno planiranje, namjena zemljišta, geohazard]]></keywords_hr><keywords_en><![CDATA[landslides, LiDAR, landslide inventory, landslide susceptibility assessment, spatial planning, land use, geohazard]]></keywords_en><summary_hr><![CDATA[Misija LandSlidePlan projekta je stjecanje novih znanja nužnih za procjenu podložnosti na klizanje u svim dijelovima Hrvatske, sa svrhom izrade karata podložnosti koje će biti korištene u procesu planiranja namjene zemljišta. Specifični ciljevi projekta su: (1) izraditi optimalni digitalni model terena bez vegetacije koji odražava morfologiju klizišta, te održava razliku između dijelova terena zahvaćenih klizanjem i dijelova terena bez klizišta; (2) izraditi pouzdanu kartu podložnosti na klizanje s najboljim prikazom područja podložnih na klizanje i područja s niskom vjerojatnosti pojave klizišta primjenom znanstvenih metoda na reprezentativnim područjima u Hrvatskoj, sa specifičnim inženjerskogeološkim uvjetima koji uvjetuju pojavu klizišta; (3) izraditi karte koje prikazuju informacije o klizištima prema potrebama sustava prostornog uređenja u Hrvatskoj, a obuhvaćaju lokalnu i regionalnu razinu te su usklađene na nacionalnoj razini. Znanstvena istraživanja će se temeljiti na inovativnim tehnologijama opažanja Zemlje, GIS analizama, statističkim metodama procjene podložnosti na klizanje, te će uzeti u obzir postojeća ograničenja koja se odnose na dostupnost prostornih podatka u Hrvatskoj te na potrebu za cjelovitim praktičnim rješenjima sustava prostornog planiranja Republike Hrvatske, sukladno s globalnim i europskim zahtjevima o održivom razvoju te zaštiti ljudi i okoliša. Zbog različitih prirodnih okoliša i tipova korištenja zemljišta u različitim dijelovima Hrvatske, metodologija će biti razvijena za tri pilot područja, odabrana na temelju karakteristične geološke građe i stupnja urbanizacije, u podsljemenskoj zoni Grada Zagreba, Hrvatskom Zagorju i Istri. Glavni rezultat primijenjenog istraživanja LandSlidePlan projekta je razvoj metodologije za procjenu podložnosti na klizanje korištenjem LiDAR tehnologije kao i izrada smjernica za praktičnu primjenu razvijene metodologije za sustavnu izradu karata klizišta kao dokumenata o ograničenjima u prostoru. ]]></summary_hr><summary_en><![CDATA[Mission of the LandSlidePlan project is to gain a new knowledge necessary for landslide susceptibility assessment in all parts of Croatia, with the objective of preparation of maps that will be used in the process of land use planning. Specific objectives of the project are: (1) to create optimal digital bare-earth model which reflects landslide morphology, and displays differences between landslide and non-landslide area; (2) to create reliable landslide susceptibility map with the appropriate presentation of spatial probability of landslide occurrence, by use of scientific methods on representative areas in Croatia, with specific engineering geological conditions; (3) to create maps which display information about landslides according to needs of the system of spatial planning in Croatia, including local and regional government and are homogenized at the national level. Scientific investigations will be based on innovative technologies of Earth Observations, GIS analyses and statistical methods of landslide susceptibility assessment considering existing limitation related to availability of spatial data in Croatia. Moreover, it is necessary to take into account needs for comprehensive practical solutions for the system of spatial planning in Croatia, in line with global and European requirements related to sustainable development, civil protection and environment. Because of variety of natural environments and types of land use in different parts of Croatia, methodology will be developed for 3 pilot areas, selected on the basis of characteristic geological settings and urbanization stage, in Podsljeme Zone in Zagreb, Hrvatsko Zagorje and Istria. The main results of the applied research of the project is methodology development for landslide susceptibility assessment using LiDAR technology as well as development of guidelines for practical application of the developed methodology for systematic production of landslide maps as documents about limitation in space.]]></summary_en></project><project>
<id>8962</id><title_hr><![CDATA[Genomska karakterizacija, konzervacija i selekcija s optimalnim doprinosima kod hrvatskih mliječnih pasmina ovaca]]></title_hr><title_en><![CDATA[Genomic characterization, preservation and optimum contribution selection of Croatian dairy sheep]]></title_en><user_id>23742</user_id><user_firstLast_name>Jelena Ramljak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-3559</code><acronim><![CDATA[OPTI-SHEEP]]></acronim><duration>01.01.2020 - 31.05.2024</duration><status>Završio</status><financ_value>105.342,09 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, Biotehnologija, </scie_field_hr><scie_field_en>Agriculture, Biotechnology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Agronomski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Agriculture]]></institution_en><team_members_id>26929, 20459, 23716, 23621, 27020, 23708, 6771, 865551, </team_members_id><team_members_names><![CDATA[Ivan Širić, Ante Ivanković, Valentino Držaić, Boro Mioč, Gregor Gorjanc, Ante Kasap, Marija Spehar, Ivan Pocrnić, ]]></team_members_names><keywords_hr><![CDATA[Ovce, mlijeko, genom, konzervacija, selekcija s optimalnim doprinosima]]></keywords_hr><keywords_en><![CDATA[Sheep, milk, genome, preservation, optimum contribution selection]]></keywords_en><summary_hr><![CDATA[PProfitabilnost uzgoja istarske (IO) i paške ovce (PO) predodređena je njihovim osobinama u proizvodnji mlijeka u okvirima postojeće ekološke niše. Selekcija na mliječnost važna je za gospodarsku održivost ovih pasmina, a održanje genetskog varijabiliteta za njihovu adaptabilnost na okolišne promjene. Ubrzanim razvojem molekularnih genetskih metoda u novije vrijeme stvoreni su uvjeti za učinkovitu i cjenovno prihvatljivu genotipizaciju većeg broja lokusa (SNPs) otvarajući mogućnost značajnije primjene genomske informacije u praksi (genomska selekcija, GS). Uvažavajući prednosti GS, prelazak na ovaj sustav u budućnosti se očekuje u svim stočarskim uzgojnim programima. Budući da prelaz na GS i njena opstojnost iziskuju značajna financijska ulaganja, potrebno je detaljno analizirati potencijal primjene GS u populacijama IO i PO. Cilj projekta je detaljnom analizom podataka u populacijama IO i PO valorizirati mogućnost primjene selekcije s optimalnim doprinosima (OCS) koja istovremeno maksimizira genetski napredak i minimalizira gubitak genetskog varijabiliteta. Navedeno se postiže simultanom selekcijom jedinki visokog genetskog potencijala i najmanjeg stupnja srodstva s ostatkom populacije. Uvažavajući OCS principe i dobivene rezultate projekt će imati dvostruki značaj: 1) „ex situ in vitro“ očuvanje „optimalnog genoma“ koji predstavlja rezultat sinergijskog djelovanja čovjeka i prirode kroz povijest i 2) „in situ in vivo“ očuvanje pasmina kroz selekcijski napredak za svojstva mliječnosti. Genotipizacijom, analizom genomskih podataka i primjenom optimizacijskih metoda ovim projektom će se omogućiti karakterizacija, očuvanje i optimizacija uzgoja mliječnih pasmina ovaca u Republici Hrvatskoj. Rezultati će doprinijeti dugovječnosti IO i PO i time osigurati brojne koristi uzgajivačima, prerađivačima i potrošačima. Također, rezultati će poslužiti i kao smjernice za provedbu selekcije uz očuvanje genetskog varijabiliteta kod drugih pasmina ovaca i vrsta domaćih životinja.]]></summary_hr><summary_en><![CDATA[Profitability of Istrian and Pag sheep dairy orientated homesteads depends on performances of Istrian (IS) and Pag (PS) sheep breeds within the existing ecological niches. Genetic improvement of dairy performance via selection is important for the economic viability of these breeds, while maintenance of the underlying genetic variability is vital for their adaptability to environmental changes. Recent developments of high throughput molecular genetic methods have provided conditions for “whole genome” genotyping (SNPs) for affordable price, which opens the possibility for widespread usage of genomic information in practice (genomic selection, GS). Given the benefits of the GS, the transition to this system is expected in the near future in all livestock breeding programs. Since the transition to GS and its’ long-term viability demand substantial investments, it is necessary to analyze the potential of long-term GS implementation in IS and PS populations. Based on a thorough analysis of the available data in the populations of IS and PS, aim of this project is to evaluate the potential of implementation of Optimum Contribution Selection (OCS) which simultaneously maximizes genetic gain and minimizes loss of genetic variability. This is achieved with the selection of genetically high-performant animals that have a minimal possible group genetic relationship. Two-fold benefit based on the OCS approach will be reflected through: 1) “ex situ in vitro” preservation of the &#39;&#39;optimal genome&#39;&#39; as the result of historical synergistic activity of man and nature, and 2) &#39;&#39;in situ in vivo&#39;&#39; preservation of the breeds through their improved genotypic profile regarding dairy traits. These project will impact long-term sustainability of IS and PS, which will benefit the breeders, consumers and corresponding (dairy) industries. By showing how to optimize selection with maintenance of genetic diversity, the results could also be beneficial to other sheep and livestock breeding programs.]]></summary_en></project><project>
<id>8963</id><title_hr><![CDATA[Transport, sudbina i toksičnost metal(oid)a otpuštenih iz ležišta industrijskog otpada]]></title_hr><title_en><![CDATA[Transport, fate and toxicity of metal(loid)s released from industrial w aste deposits]]></title_en><user_id>2726</user_id><user_firstLast_name>Željka Fiket</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-9354</code><acronim><![CDATA[FORtIS / FORtIS]]></acronim><duration>01.12.2019 - 30.11.2023</duration><status>Završio</status><financ_value>114.805,23 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Interdisciplinarne prirodne znanosti, Geologija, Kemija, Biologija, </scie_field_hr><scie_field_en>Interdisciplinary natural sciences, Geology, Chemistry, Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>12337, 26697, 24517, 4415, 624, 6000, 26631, 22577, 858378, 19214, </team_members_id><team_members_names><![CDATA[Antonela Ninčević Grassino, Jelena Loborec, Sanja Kapelj, Maja Ivanić, Neda Vdović, Matej Dolenec, Uroš Herlec, Gordana Medunić, Marija Petrović, Željka Vidaković-Cifrek, ]]></team_members_names><keywords_hr><![CDATA[odlagališta otpada, geokemija okoliša, biogeokemija, toksičnost, ranjivost podzemnih voda, procjedne vode]]></keywords_hr><keywords_en><![CDATA[waste deposits, environmental geochemistry, biogeochemistry, toxicity, groundwater vulnerability, waste leachates]]></keywords_en><summary_hr><![CDATA[Depoziti nastali odlaganjem industrijskog otpada predstavljaju dugotrajnu opasnost od onečišćenja kao potencijalna mjesta otpuštanja raznih onečišćujućih tvari, uključujući i metal(loid)e, s mogućnošću ozbiljnog zagađenja tla, površinskih i podzemnih voda u regiji, čak i desetljećima nakon njihovog odlaganja. Projekt FORtIS ima za cilj istražiti svojstva i utjecaj na okoliš četiri različita odlagališta industrijskog otpada obogaćenog metal(oid)ima koristeći, između ostalog, i svojstva procjednih voda. Područja istraživanja uključit će odlagalište ugljenog pepela i odlagalište pepela bivše tvornice sulfatne celuloze kao otpadni materijal visoke opasnosti, deponij tvornice čelika kao otpadni materijal srednjeg stupnja opasnosti, te bivšu tvornicu glinice kao otpad materijal umjerene opasnosti.Specifični ciljevi projekta uključuju: 1) ispitivanje osnovnih značajki otpada I okolnih tala, 2) istraživanje geokemijskih i mineralnih svojstava otpada i okolnih tla, 3) ispitivanje svojstava eluata otpada i okolnih tla, 4) istraživanje ekotoksikoloških značajki procjednih voda; 5) procjena mogućeg utjecaja na okoliš.Transport, sudbina i toksičnost metal(oid)a koji se otpuštaju iz spomenutih depozita industrijskog otpada istražit će se kroz skup fizikalno-kemijskih, morfoloških, mineraloških, geokemijskih i bioloških parametara kao i primjenom geokemijskog modeliranja i procjene rizika.Rezultati istraživanja pridonijet će razumijevanju načina pojavljivanja metal(oid)a koji se otpuštaju iz istraženih i sličnih vrsta otpada, procesa i mehanizama koji utječu na njihov ciklus u okolišu kao i detaljniji uvid u njihove bioreaktivne oblike. Rezultati projekta FORtIS predstavljat će važan doprinos znanju potrebnom za određivanje i provedbu strategija čiji je cilj minimiziranje negativnih utjecaja na okoliš vezanih uz odlaganje industrijskih otpada obogaćenih metal(oid)ima.]]></summary_hr><summary_en><![CDATA[Deposits arising from industrial waste disposal operations represent a long-term pollution risk as potential release points of various pollutants, including metal(loid)s, with the ability to severely contaminate soils, surface and groundwater in the region, even decades after their disposal. Project FORtIS aims to address the environmental impact of four different industrial waste deposits enriched in metal(loid)s using, inter alia, their leachates features. The location of interest will include the coal ash deposit and the ash deposit of the former sulphate cellulose factory as waste materials of high hazard score, the scrapyard of the steel factory as waste materials of medium hazard score, the ex-alumina factory deposit as waste materials of moderate hazard score.Specific objectives of the project will include the investigation of 1) the basic characteristics of the waste and surrounding soils, 2) the geochemical and mineral characteristics of waste and surrounding soils, 3) the chemistry of waste and soil leachates, 4) the ecotoxicological features of waste and soil leachates, and the assessment of 5) the potential environmental impact. Transport, fate and toxicity of metal(loid)s released from mentioned industrial waste deposits will be investigated through a set of physico-chemical, morphological, mineralogical, geochemical and biological parameters as well as the geochemical modeling and risk assessment. Results of the research will contribute to the understanding of the modes of occurrences of metal(loid)s released from investigated and similar waste deposits, processes and mechanisms that influence their environmental cycling, as well as more detailed insight into their bioreactive forms. The results of the FORtIS project will present an important contribution to the knowledge necessary to determine and implement strategies aimed at minimizing the negative environmental impacts related to deposition of industrial wastes enriched in metal(loid)s.]]></summary_en></project><project>
<id>8974</id><title_hr><![CDATA[Otkrivanje organizacije i funkcije kolesterolove domene u plasma membrani fibroznih stanica leće oka uz primjenu fluorescentnih metoda]]></title_hr><title_en><![CDATA[Unravelling cholesterol-domain organization and function in the plasma membrane of the eye lens fiber cells using fluorescent methods]]></title_en><user_id>6123</user_id><user_firstLast_name>Marija Raguž</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-1958</code><acronim><![CDATA[BioPhyCBD]]></acronim><duration>20.12.2019 - 19.05.2024</duration><status>Završio</status><financ_value>127.679,34 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Split School of Medicine]]></institution_en><team_members_id>20309, 23875, 23517, 24061, 23895, 24048, 856215, </team_members_id><team_members_names><![CDATA[Ljubo Znaor, Josipa Marin Lovrić, Zvonimir Boban, Witold Subczynski, Ana Vučinović, Akihiro Kusumi, Ivan Mardešić, ]]></team_members_names><keywords_hr><![CDATA[Očna mrena, kolesterol, domena dvosloja kolesterola, kristali kolesterola, očna leća, membrana fibroznih stanica, kisik, fluorescencija]]></keywords_hr><keywords_en><![CDATA[Cataract, cholesterol, cholesterol bilayer domain, cholesterol crystal, eye lens, fiber cell membrane, oxygen, fluorescence]]></keywords_en><summary_hr><![CDATA[Očna mrena je glavni uzrok sljepoće u svijetu. Operacija je trenutno jedini učinkovit tretman. Razlog za pojavu očne mrene je nepoznat, ali veliki broj dokaza ukazuje na to da prisutnost kolesterola i domena dvosloja kolesterola (DDKa) u očnoj leći pomaže u održavanju njene transparentnosti. Membrane očne leće igraju važnu ulogu u održavanju transparentnosti. Imaju jedinstven lipidni sastav i strukturu koja spriječava stvaranje očne mrene. U ovom istraživanju ćemo se usredotočiti na ulogu lipidnog dijela dvosloja membrane fibroznih stanica u održavanju homeostaze fibroznih stanica i leće. Prisutnost DDKa osigurava zasićenost okolnog fosfolipidnog dvosloja kolesterolom. Ove osobine održavaju glavna fizikalna svojstva lipidnih membrana leća konzistentnima i neovisnim o promjenama u fosfolipidnom sastavu. Dakle, DDKa pomažu u održavanju homeostaze membrane leće dok se membranski fosfolipidni sastav značajno mijenja sa starenjem. U ovom projektnom prijedlogu, prilagodit ćemo postojeće metode za pripremu modelnih membrana s visokim sadržajem kolesterola (odgovarajući modeli membrane fibroznih stanica) i primijeniti ih na ispitivanje membrana fibroznih stanica primjenjujući fluorescentne metode. Temeljem ovih istraživanja istražit ćemo promjene membrana fibroznih stanica koje se javljaju sa starenjem i pojavom mrene. Posebnu pažnju ćemo posvetiti određivanju glavnih razlika u organizaciji lipida u membranama leća osoba s mrenom i onih s prozirnim lećama iste starosti. U ovim studijama će se primjenjivati fluorescentna mikroskopija i protočna citometrija. Naš je cilj razjasniti kako se plazma membrane fibroznih stanica leće, a posebno njen lipidni dvosloj, mijenjaju tijekom starenja i stvaranja mrene, tako da se alternativne strategije za sprječavanje, usporavanje, napredovanje i liječenja mogu predložiti i razviti. ]]></summary_hr><summary_en><![CDATA[Cataracts are a major cause of blindness throughout the world. Surgery at present is the only effective treatment. The reason for the onset of cataracts is unknown, but a great deal of evidence suggests that the presence of high cholesterol content and cholesterol bilayer domains (CBDs) in the eye lens helps to maintain lens transparency. The eye lens membranes play important role in maintaining lens transparency. They have unique lipid composition and structure thought to protect against cataract formation. In this research we will focus on the role of the lipid bilayer portion of fiber cells membranes in maintaining fiber cell and lens homeostasis. The presence of the CBD ensures that the surrounding phospholipid bilayer is saturated with cholesterol. The saturating cholesterol content in fiber cell membranes keeps the bulk physical properties of lens lipid membranes consistent and independent of changes in phospholipid composition. Thus, the CBD helps to maintain lens-membrane homeostasis while the membrane phospholipid composition changes significantly with age. In this grant proposal, we will adapt recently existing methods for preparation of model membranes with high cholesterol content (appropriate models of fiber cell membranes) and apply them to investigate fiber cell membranes using fluorescent approaches. Based on these investigations we will examine changes in fiber cell membranes occurring with age and cataract formation. Special attention will be paid to determine major differences in the organization of lipids in lens membranes of people with cataractous and age-matched clear lenses. For this studies fluorescent microscopy and flow cytometry will be used. Our goal is to understand how fiber cell plasma membranes in the lens, in particular their lipid bilayer portion, change during aging and cataract formation so that alternative strategies for prevention, slowing the progression, and cure can be devised and evaluated.]]></summary_en></project><project>
<id>8976</id><title_hr><![CDATA[Zeoliti s malim šupljinama modificirani bakrom pogodni za primjenu u zaštiti okoliša]]></title_hr><title_en><![CDATA[Copper-modified Small-pore Zeolites Suitable for Environmental Applications]]></title_en><user_id>620</user_id><user_firstLast_name>Ana Palčić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2019-04</proposal_call><code>UIP-2019-04-4977</code><acronim><![CDATA[SMALLPORE]]></acronim><duration>01.03.2020 - 28.02.2025</duration><status>Završio</status><financ_value>217.552,59 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, Interdisciplinarne prirodne znanosti, </scie_field_hr><scie_field_en>Chemistry, Interdisciplinary natural sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>26465, 865073, 866590, 870700, </team_members_id><team_members_names><![CDATA[Magdalena Jablonska, Nikola Jakupec, Mladenka Jurin Jurin, Marko Jajčević, ]]></team_members_names><keywords_hr><![CDATA[zeoliti, male šupljine, bakar, dušikovi plinovi, uklanjanje]]></keywords_hr><keywords_en><![CDATA[zeolite, small pore, copper, nitrogen containing gases, elimination]]></keywords_en><summary_hr><![CDATA[Zeoliti su mikroporozni aluminosilikatni materijali definirane kristalne strukture unutar koje se nalazi sustav šupljina povezanih kanalima. Zbog specifične strukture i kemijskog sastava imaju veliku unutarnju površinu, adsorpcijski kapacitet te kapacitet ionska zamjene. Također su termički stabilni, a razina njihove hidrofobnosti se može mijenjati. Zeoliti s malim šupljinama imaju otvore šupljina omeđene osmeročlanim prstenovima. Pokazali su se izvrsnimkatalizatorima u procesu sinteze olefina iz metanola, ali i pri uklanjanju različitih štetnih plinova, posebice ispušnih plinova koji sadrže dušik. U sklopu predloženog projekta će se prirediti serija uzoraka zeolita s malim šupljinama (strukturni tipovi CHA, LTA, LEV) te provesti ionska zamjena bakrom kako bi se generirali metalni centri potrebni za katalitičke reakcije koje dovode do smanjenja emisije štetnih plinova. Kako bi se pripravili materijali s poboljšanimsvojstvima, sinteza materijala će biti potpomognuta mehanokemijskom predobradom polaznih spojeva. Mehanokemijski postupak će se također primijeniti prilikom ionske zamjene bakrom. Provest će se temeljita karakterizacija uzoraka, a oni koji će pokazati zadovoljavajuću (hidro)termičku stabilnost; količinu defekata unutar strukture; oblik i veličinu čestica; vrstu, jakost i raspodjelu kiselih mjesta te tip i raspodjelu bakrovih vrsti će biti ispitani kao katalizatori pri reakcijama uklanjanja plinovitih dušikovih spojeva. Posebna pozornost će se posvetiti ispitivanju djelovanja pripravljenih materijala prilikom selektivne katalitičke redukcije dušikovih oksida amonijakom te selektivne katalitičke oksidacije amonijaka.]]></summary_hr><summary_en><![CDATA[Zeolites are microporous crystalline alumosilicate materials with well-defined system of channels and cages. Due to their specific structure and chemical composition they have large internal surface area, adsorption capacity as w ell as ion-exchange capacity. They are thermally stable and the level of their hydrophobicity is tunable. Small-pore zeolites have pore openings comprising eight-membered rings. They present excellent catalyitic activity in thesynthesis of olefins from methanol (MTO), as w ell as in the elimination of various harmful gases, particularly nitrogen-containing exhaust gases. W ithin the proposed project, a series of small-pore zeolite materials (CHA-, LTA-, LEV-framew ork types) will be synthesized and subsequently ion-exchanged by copper which w ill generate the metal centers required for catalytic reactions leading to a reduction in the emission of harmful gases. In order to preparematerials with improved properties, the synthesis of the materials w ill be mechanochemically assisted by the pre-treatment of the starting compounds. The mechanochemical treatment is also going to be applied during the ion-exchange with copper. The obtained samples will be thoroughly characterized and those that will show adequate (hydro) thermal stability; quantity of the structural defects; particles’ shape and size; type, strength and distribution ofacid sites, as w ell as the type and distribution of the copper species are going to be tested as catalysts in the reactions of the gaseous nitrogen compounds removal. Particular attention will be devoted to the evaluation of catalytic activity of the prepared materials in the selective catalytic reduction of nitrogen oxides by ammonia and the selective catalytic oxidation of ammonia.]]></summary_en></project><project>
<id>9005</id><title_hr><![CDATA[Fenomeni na površini tijekom priprave naprednih nanokompozita infiltracijom i funkcionalizacijom poroznih materijala]]></title_hr><title_en><![CDATA[Surface limitations in preparing and infiltration of hard porous nanomaterial by soft or liquid precursors for performance enhancing]]></title_en><user_id>1338</user_id><user_firstLast_name>Vilko Mandić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2019-04</proposal_call><code>UIP-2019-04-2367</code><acronim><![CDATA[SLIPPERYSLOPE]]></acronim><duration>01.02.2020 - 31.01.2025</duration><status>Završio</status><financ_value>265.412,44 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Kemijsko inženjerstvo, </scie_field_hr><scie_field_en>Chemical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet kemijskog inženjerstva i tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Chemical Engineering and Technology]]></institution_en><team_members_id>861734, 864819, 22641, 863809, 869719, </team_members_id><team_members_names><![CDATA[Arijeta Bafti, Floren Radovanović-Perić, Ivana Panžić, Marko Rukavina, Davor Gašparić, ]]></team_members_names><keywords_hr><![CDATA[Površine, Poroznost, Infiltracija, Nanomaterijali, Grazing, Skliski kompoziti, Postupno otpuštanje]]></keywords_hr><keywords_en><![CDATA[Surface, Porous, Infiltration, Nanomaterials, Grazing, Slippery composites, Sustained release]]></keywords_en><summary_hr><![CDATA[Neophodno je unaprijediti pokazatelje učinkovitosti funkcionalnih materijala. U zadnje vrijeme, ova nejasna izjava prati istraživanje i razvoj naprednih materijala, kompozita i strukturiranih materijala koji teže uređenosti i funkcionalnosti na nano razini. Kao praktični ishod tijeka istraživanja česte su izjave poput: mehanizmi i razmjer kontakta faza nisu jasni na temelju čega je utvrđena potreba za daljnjim istraživanjem…Suprotno tome, ovaj projekt jasno utvrđuje da su procesi na i oko površine ključne za postizanje unaprjeđenja u širokom području naprednih materijala. Naime, istraživači koji se bave površinama još u potpunosti ne kontroliraju procese u planarnim uzorcima među sastavno jednostavnim fazama pri atmosferskim uvjetima. U tum duhu, ovaj projekt želi posvetiti pažnju razjašnjavanju složenijih aspekata istraživanja površina materijala.Posebno atraktivno i kompleksno, a nedovoljno istraženo je područje kontakta poroznih ili nanostrukturiranih materijala sa drugim materijalima korištenjem metoda mokre kemije. Problemi razumijevanja mehanizama unaprjeđenja svojstava materijala prilikom kontakta poroznih čvrstih i kapljevitih materijala su još izraženiji. Praćenje takvih konfiguracija praćeno je ključnim pitanjima:1) Kako kontrolirati procese potrebne za pripravu takvih materijala i svojstva?2) Kako uočiti, potvrditi i procijeniti pripravljene materijale i svojstva?3) Kako razumjeti i predvidjeti ponašanje materijale i svojstva?Cilj projekta je uspostaviti efikasnu ustraživačku grupu sa nezavisnim smjerom istraživanja u znanosti materijala. Grupa će na temelju dosadašnjih pokazatelja izvrsnosti i uspostavljenih domaćih i međunarodnih kanala suradnje biti u stanju interdisciplinarno primijeniti rezultate ovog istraživanja.]]></summary_hr><summary_en><![CDATA[The increase of performance parameters of functional materials is recently becoming increasingly important. In recent times, this relatively ambiguous expression accompanies the course of development of various composites, materials reaching to nano-seizes, materials implementing ordered structuration, etc. In reality, it seems that the outcome of this course of development is commonly the need to conduct further investigation since, for example, it was found that the mechanisms of the extent of the interfacing of the phases are not clear…Opposite of that, this project identifies the reactions at broader surface region as a bottleneck for upgrading performance of broad range of functional materials. Namely, the surface researchers still struggle to fully understand reactions even at planar samples between phases having simple composition that are stable at atmospheric conditions. Therefore, this project aim to devote more attention in more complex aspects of the surface science. The especially ambiguous area are porous or nanostructured oxide materials interfaced with other oxide materials using soft chemistry techniques to form heterostructures. Even more difficult is understanding of the systems where the properties of hard materials should be improved upon infiltration with special soft matter or liquids. Mentioning of such configurations immediately raise question such as: 1) How to control processes behind achieving the feature? 2) How to observe, confirm and evaluate the achieved feature? 3) How to understand and predict the performance of feature? The aim is to establish effective research group with independent course of research in material science. The group would benefit on excellent recent track-record and established national and international collaboration pathways to allow interdisciplinary applicability of the project results. ]]></summary_en></project><project>
<id>9006</id><title_hr><![CDATA[Mitohondrijske podpopulacije i UPRmt u dijabetičkoj kardiomiopatiji]]></title_hr><title_en><![CDATA[Mitochondrial Subpopulations and UPRmt in Diabetic Cardiomyopathy]]></title_en><user_id>6752</user_id><user_firstLast_name>Filip Sedlić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-1449</code><acronim><![CDATA[SweetMitochondria]]></acronim><duration>01.01.2020 - 30.06.2024</duration><status>Završio</status><financ_value>134.846,37 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Kliničke medicinske znanosti, Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Clinical sciences, Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>6755, 4288, 13271, 23942, 27152, 25311, 21389, 865168, </team_members_id><team_members_names><![CDATA[Ana Šepac, Vesna Kušec, Ana Kulić, Tomo Svaguša, Fran Seiwerth, Sunčana Sikirić, Petra Baković, Vid Mirošević, ]]></team_members_names><keywords_hr><![CDATA[mitohondriji, srčano zatajivanje, UPRmt, oksidativni stres, dijabetes]]></keywords_hr><keywords_en><![CDATA[mitochondria, failing heart, UPRmt, oxidative stress, diabetes]]></keywords_en><summary_hr><![CDATA[Mitochondrijska disfunkcija igra važnu ulogu u dijabetičkoj kardiomiopatiji. Mitohondrijski odgovor na nesmotane proteine (UPRmt) je jedan od ključnih mehanizama uključenih u regulaciju ispravne mitohondrijske funkcije. Uloga UPRmt-a nije istražena u dijabetičkoj kardiomiopatiji. Ovaj je prijedlog osmišljen kako bi istražio ulogu UPRmt-a u dijabetičkoj kardiomiopatiji, fokusirajući se na predloženi molekularni prekidač Yme1L-Oma1.Naši preliminarni podatci pokazuju da visoka razina glukoze smanjuje izražaj proteina Yme1L, okidača i efektora UPRmt-a. mitoTEMPO, antioksidans usmjeren na mitohondrije vraća ekspresiju proteina Yme1L. To ukazuje na uključenost ROS-a u smanjenju Yme1L-a visokom glukozom. Preliminarni podatci također pokazuju da visoka razina glukoze ubrzava otvaranje mPTP-a i povećava proizvodnju ROS-a.Naši će pokusi biti provedeni na izoliranim kardiomiocitima, srcima štakora s dijabetesom i ljudskom miokardu sa znakovima zatajivanja. Uloga UPRmt-a u dijabetičkoj kardiomiopatiji istraživat će se na nekoliko načina. Testirat ćemo izražaj UPRmt markera i predloženi molekularni prekidač koji regulira aktivaciju UPRmt-a pomoću qPCR-a i western blota. Otvaranje mPTP-a i stvaranje ROS-a testirat će se konfokalnom mikroskopijom, dok će stanična apoptoza i mitohondrijski kalcij biti testirani fluorimetrijskim pristupom. Vrijeme otvaranja mPTP-a i stvaranje ROS-a također će se analizirati u prethodno identificiranim mitohondrijskim podpopulacijama, subsarkolemalnim i interfibrilarnim mitohondrijima. Stupanj oštećenja srca bit će testiran imunopatohistološki. Primijenit ćemo prekomjerni izražaj Yme1L-a i utišavanje Oma1 te tretman s mitoTEMPO-om s ciljem obnavljanja Yme1L-Oma1 balansa, obnavljanja UPRmt-a i ublažavanja dijabetičke kardiomiopatije. ]]></summary_hr><summary_en><![CDATA[Mitochondrial dysfunction plays important role in diabetic cardiomyopathy. Mitochondrial unfolded protein response (UPRmt) is one of key mechanisms involved in regulation of proper mitochondrial function. However, the role of UPRmt is not investigated in diabetic cardiomyopathy. This proposal is designed to investigate the role of UPRmt in diabetic cardiomyopathy, focusing on the proposed Yme1L-Oma1 molecular switch.Our preliminary data show that high glucose downregulates Yme1L protein, a trigger and effector of UPRmt. mitoTEMPO, a mitochondria-targeted antioxidant restores Yme1L protein expression. This indicates involvement of ROS in glucose-induced Yme1L downregulation. Preliminary data also show that high glucose accelerates mPTP opening and increases ROS generation. Our experiments will be conducted on isolated cardiomyocytes, diabetic rat hearts and failing human myocardium. The role of UPRmt in diabetes-induced cardiomyopathy will be investigating by several approaches. We will be testing the expression of UPRmt markers and proposed molecular switch that regulates activation of UPRmt by qPCR and western blot. mPTP opening and ROS generation will be tested by confocal microscopy, while cell apoptosis and mitochondrial calcium will be testes by fluorimetric approaches. The mPTP opening time and ROS generation will be also analyzed in previously identified mitochondrial subpopulations, subsarcolemmal and interfibrilar mitochondria. The extent of heart damage will be tested immunopathohistologically. We will apply Yme1L overexpression, Oma1 silencing and mitoTEMPO treatment to restore Yme1L-Oma1 balance, restore UPRmt and ameliorate diabetic cardiomyopathy.]]></summary_en></project><project>
<id>9009</id><title_hr><![CDATA[Sferni optički mikrorezonatori za senzoriku, lasere i nelinearnu optiku]]></title_hr><title_en><![CDATA[Spherical optical microresonators for sensing, lasing and non–linear optics]]></title_en><user_id>4296</user_id><user_firstLast_name>Davor Ristić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-3045</code><acronim><![CDATA[SOMSLNO]]></acronim><duration>01.12.2019 - 30.11.2023</duration><status>Završio</status><financ_value>132.590,09 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, Kemija, </scie_field_hr><scie_field_en>Physics, Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>25761, 25764, 25760, 25762, 25968, 25976, 25989, 25454, 3743, 25427, 865283, </team_members_id><team_members_names><![CDATA[Gualtiero Nunzi Conti, Féron Patrice, Elena Romanova, Maurizio Ferrari, Anna Lukowiak, Vladimir Shiryaev, Boris Stepanov, Vlatko Gašparić, Hrvoje Gebavi, Daniil Zhivotkov, Snigdha Thekke Thalakkal, ]]></team_members_names><keywords_hr><![CDATA[Optički mikrorezonatori, modovi šapučuće galerije, laseri, senzor plina, nelinearna optika]]></keywords_hr><keywords_en><![CDATA[Optical microresonators, whispering gallery modes, lasers, gas sensors, non-linear optics]]></keywords_en><summary_hr><![CDATA[Projekt SOMSLNO obuhvaćat će proizvodnju, karakterizaciju i funkcionalizaciju sfernih optičkih mikrorezonatora (mikrosfera). Iskoristit će se već postojeći eksperimentalni postav na Institutu Ruđer Bošković (IRB) koji omogućuje proizvodnju visokokvalitetnih (Q> 10^7) optičkih mikrorezonatora od kvarcnog stakla i njihovu karakterizaciju. Projekt će obuhvatiti nadogradnju eksperimentalnog postava kako bi se omogućilo mjerenje nelinearnih optičkih efekata u mikrorezonatorima i oblaganje mikrorezonatora s optički aktivnim i pasivnim slojevima. Osim mikrosfera od kvarcnog stakla, projekt će uključivati i proizvodnju mikrosfera izrađenih od teluritnih i halkogenidnih stakala. Obložene sfere proučavat će se za primjene kao senzori plina (sfere obložene poroznim silicijem), kao laseri (obložene sfere od kvarcnog i teluritnog stakla) i u nelinearnoj optici (halkogenidne sfere). Projekt će biti podijeljen u 5 ciljeva (O1-O5). O1 će se baviti konstrukcijom sustava za spregu svjetlosti u sferu pomoću prizme. Upotrijebit će se kao alternativna metoda metodi sprege pomoću suženog optičkog vlakna koja je već prisutna na IRB-u. O2 će se baviti oblaganjem mikrosfera za primjenu kao senzor plina. Sfere će biti obložene poroznim silicijevim dioksidom i bit će korištene za detekciju različitih plinova kao što su amonijak ili pare etanola. O3 će se baviti proizvodnjom sfera od halkogenidnog stakla za primjenu u nelinearnoj optici. O4 će se baviti proizvodnjom sfera dopiranih s rijetkim zemljama za primjenu kao laseri. Mikrolaseri će biti proizvedeni kako oblaganjem mikrosfera od kvarcnog stakla sol-gel dobivenim slojevima, tako i proizvodnjom sfera od teluritnog stakla dopiranih rijetkim zemljama. O5 će se baviti proučavanjem optoakustičkih vibracija mikrosfera.]]></summary_hr><summary_en><![CDATA[The scope of the SOMSLNO project will be the production, characterization and functionalization of spherical optical microresonators (microspheres). It will take advantage of the already existing experimental facilities at the Ruđer Bošković Institute(RBI) that make possible the production of high quality (Q>10^7) optical silica microresonators and their characterization. The project will include the upgrade of the experimental facilities to make possible the measurement of nonlinear optical effects in microresonators and the coating of microresonators with optically active and passive layers. In addition to silica microsphere the project will include the production of microspheres made of tellurite and chalcogenide glasses. The coated spheres will be studied for applications in gas sensing (porous silicon coated spheres), lasing (coated silica spheres and tellurite spheres) and non-linear optics (chalcogenide spheres). The project will be divided into 5 objectives (O1-O5).  O1 will deal with the construction of the prism coupling system which will be used for coupling light into and out of the sphere. It will be used in addition to the taper coupling method already present at the RBI. O2 will deal with the coating of silica microspheres for use as gas sensors. The spheres will be coated with porous silicon and will be used to sense various gasses such as ammonia or ethanol vapors. O3 will deal with the production of chalcogenide glass spheres for use in nonlinear optics applications. O4 will deal with the production of rare earth doped spheres for lasing applications. Microlasers will be produced both by coating silica microspheres with sol-gel layers and by producing rare earth doped tellurite glass spheres. O5 will deal with the study of optoacoustical vibrations of the microspheres.]]></summary_en></project><project>
<id>9010</id><title_hr><![CDATA[Dobrobit djeteta u kontekstu obitelji]]></title_hr><title_en><![CDATA[Child Well-being in Family Context]]></title_en><user_id>133</user_id><user_firstLast_name>Andreja Brajša-Žganec</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-6198</code><acronim><![CDATA[CHILD-WELL]]></acronim><duration>01.02.2020 - 30.11.2024</duration><status>Završio</status><financ_value>69.097,48 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Psihologija, </scie_field_hr><scie_field_en>Psychology, </scie_field_en><institution_hr><![CDATA[Institut društvenih znanosti Ivo Pilar]]></institution_hr><institution_en><![CDATA[Institute of Social Sciences Ivo Pilar in Zagreb]]></institution_en><team_members_id>67, 6293, 5219, 2783, 1255, 6242, 26089, 20236, 26184, 23199, 26513, 26676, 26525, 865332, </team_members_id><team_members_names><![CDATA[Ljiljana Kaliterna Lipovčan, Toni Babarović, Tihana Brkljačić, Marina Kotrla Topić, Zvjezdana Prizmić-Larsen, Maja  Tadić Vujčić, Renata Miljević-Riđički, Ivana Hanzec Marković, Marija Džida, Lana Lučić, Lisa Newland, Ferran Casas, Daniel  Shek, Maja Kućar Kućar, ]]></team_members_names><keywords_hr><![CDATA[dobrobit, dijete, obitelj, roditeljstvo, digitalne tehnologije, longitudinalno, srednje djetinjstvo i rana adolescencija]]></keywords_hr><keywords_en><![CDATA[well-being, child, family, parenting, digital technologies, longitudinal, middle childhood and early adolescence ]]></keywords_en><summary_hr><![CDATA[Dobrobit djece je multidimenzionalni konstrukt koji obuhvaća kognitivnu, bihevioralnu i emocionalnu regulaciju, socijalnu kompetenciju te indikatore subjektivne dobrobiti djece. U zadnje vrijeme sve je veći naglasak na istraživanju subjektivne dobrobiti djece. Postoji relativno malo istraživanja promjena u različitim domenama dobrobiti, osobito u domenama subjektivne dobrobiti, u srednjem djetinjstvu te na prijelazu u adolescenciju. Osim toga, nije sasvim jasna priroda i smjer promjena u različitim domenama dobrobiti. Istraživanja pokazuju da su karakteristike roditelja i obitelji važni prediktori različitih aspekata dobrobiti djece. Stoga je važno istražiti ulogu obiteljskog konteksta u razvoju dobrobiti djece. Uz to istražit će se i uloga korištenja digitalnih medija u predviđanju dobrobiti djece. U ovom projektu koristit će se longitudinalno-sekvencijalni kohortni istraživački nacrt kako bi se provjerila (ne)stabilnost različitih domena dobrobiti djece te kako bi se ispitao doprinos različitih karakteristika obiteljskog konteksta i roditeljskih ponašanja za predviđanje dobrobiti djece. Tijekom 4 godine, planiraju se provesti 3 vala istraživanja s djecom u dobi od 9, 10 i 11 godina u prvoj točki mjerenja. U sva 3 vala djeca će procjenjivati vlastitu subjektivnu dobrobit te korištenje digitalnih tehnologija, roditelji će procjenjivati kognitivnu, bihevioralnu i emocionalnu regulaciju djece te obiteljsku dobrobit i roditeljska ponašanja, a učitelji će procjenjivati socijalnu kompetenciju djece. Na temelju dosadašnjih istraživanja, očekuje se pad u subjektivnim mjerama dobrobiti djece te porast u mjerama kognitivne, bihevioralne i emocionalne regulacije i socijalne kompetencije djece. Očekuje se da će karakteristike obitelji predviđati dobrobit djece direktno i preko roditeljskih ponašanja zasebno za majku i oca. Rezultati ovog istraživanja omogućit će proširenje spoznaja o promjenama i odrednicama dobrobiti djece u srednjem djetinjstvu te ranoj adolescenciji. ]]></summary_hr><summary_en><![CDATA[Child well-being is a multidimensional construct that encompasses cognitive, behavioral and emotional regulation, social competence, and subjective well-being of children. There is relatively little research of changes in different domains of well-being, especially in domains of subjective well-being, in middle childhood and during transition to adolescence. The nature and direction of these changes in different well-being domains are not quite clear. Research shows that characteristics of parents and families are important predictors of different aspects of child well-being. It is therefore important to explore the role of the family context in the development of child well-being. The role of digital media in predicting the well-being of children will also be examined. Longitudinal-sequential cohort study will be used to examine the (in)stability of different child well-being domains and to explore the contribution of different characteristics of the family context and parental behavior in prediction of child well-being. During 4 years, 3 waves of research will be conducted with children aged 9, 10 and 11 in the first measurement point. In all three waves, children will evaluate their own subjective well-being and digital technology usage, parents will assess cognitive, behavioral and emotional regulation of children, family wellbeing and parental behavior, and teachers will assess the child&#39;s social competences. Based on previous research, a decrease in subjective well-being and an increase in cognitive, behavioral and emotional regulation, and social competence of children is expected. It is expected that family characteristics will predict the well-being of children directly and through parental behavior separately for mother and father. The results of this research will enable the understanding of the changes and determinants of child well-being in middle childhood and early adolescence. ]]></summary_en></project><project>
<id>9013</id><title_hr><![CDATA[Metalni kompoziti za ultra-tanke infracrvene slojeve]]></title_hr><title_en><![CDATA[Metal composites for ultrathin infrared coatings]]></title_en><user_id>812</user_id><user_firstLast_name>Jordi Sancho-Parramon</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-5424</code><acronim><![CDATA[METACUC]]></acronim><duration>01.02.2020 - 30.06.2024</duration><status>Završio</status><financ_value>194.438,91 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, Kemija, Interdisciplinarne prirodne znanosti, </scie_field_hr><scie_field_en>Physics, Chemistry, Interdisciplinary natural sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>21151, 1019, 2916, 2656, 25286, 20041, 2846, 20097, 865263, 866633, </team_members_id><team_members_names><![CDATA[Stefano (Antonio) Mezzasalma, Vesna Janicki, Vesna Blažek Bregović, Boris Okorn, Matej Bubaš, Zoran Ereš, Jordi Arbiol, Ivana Fabijanić, Elizabeth Hedl, Nirmala Maria D&amp;#39;souza, ]]></team_members_names><keywords_hr><![CDATA[metalni kompositi, tanke slojeve, optička svjostava, perkolacija, infracrveno, hybridne čestice]]></keywords_hr><keywords_en><![CDATA[metal composites, thin films, optical properties, percolation, infrared, hybrid particles]]></keywords_en><summary_hr><![CDATA[Materijali s velikim gubicima, tj. s velikom ali konačnom vodljivošću, stvaraju složene pomake faze svjetla nakon refleksije. Zbog toga se mogu pojaviti jake interferencije u ultratankim filmovima, što je nedavno iskorišteno za dizajniranje apsorbera, sistema koji daju strukturalne boje i fotonaponskih sustava za vidljivo područje. Ako bi se primijenio u infracrvenom području, ovaj pristup bi mogao bitno transformirati tehnologiju slojeva, gdje je proizvodnja u konačnici ograničena minimalnom potrebnom debljinom. Međutim, materijali s visokim gubitkom u infracrvenom dijelu spektra su rijetki, budući da metali, koji imaju velike gubitke u vidljivom području, djeluju kao gotovo savršeni vodiči na većim valnim duljinama.Cilj ovog projekta je istražiti metalne kompozite kao materijale s velikim gubicima za ultra tanke infracrvene višeslojne sustave. Istraživanje će se fokusirati na: i) legurama metala, ii) slojevima hibridnih metalnih otočića i iii) metalnim slojevima u blizini praga perkolacije. Ovi sustavi potencijlano mogu pružiti znatno veće optičke gubitke od čistih metala radi svoje neuređenosti, prigušivanja na međupovršinama i elektromagnetske sprege među česticama. Prvi cilj projekta je unaprijediti temeljno razumijevanje ovakvih povećanih gubitaka pomoću teorijskih pristupa (ab-initio izračuna, elektrodinamičke simulacije i modeliranja tranzicije perkolacije i optičkih svojstava). Teorijski rad bit će potvrđen kombinacijom različitih eksperimentalnih pristupa izradi i modifikaciji uzoraka (nanošenje tankih slojeva, galvanska zamjena i žarenje) i tehnika karakterizacije. U drugoj fazi, stečeno znanje će se koristiti za izradu novih infracrvenih slojeva s naglaskom na temperaturnim prekidačima i ultratankim interferencijskim sustavima. Osim temeljne vrijednosti, potencijal teme projekta u primjeni ojačat će domaću instituciju kao budućeg partnera industriji. Projekt će mladim istraživačima omogućiti razvoj konkurentnih znanstvenih karijera u Hrvatskoj.]]></summary_hr><summary_en><![CDATA[It has been shown that highly lossy materials, i.e. with large but finite conductivity, generate complex phase shifts of light upon reflection. As a result strong interference can take place in ultrathin films, what has been recently exploited to design absorbers, structural coloration devices and photovoltaic systems for the visible range. If applied to infrared range, this approach could deeply transform coating technology, where fabrication is ultimately limited by the minimal required layers thickness. However, highly lossy materials are scarce in the infrared, since metals, that have large losses in the visible range, act as nearly perfect conductors in the infrared.The project aims to investigate metal composites as highly lossy materials for ultrathin infrared coatings. The research will focus on: i) metal alloys, ii) hybrid metallic island films and iii) nearly-percolated metal films. These systems can potentially provide significantly larger optical losses than pure metals due to disorder, interface damping and inter-particle coupling. The first project goal is to advance in fundamental understanding of these enhanced losses by means of several theoretical approaches (ab-initio calculations, electrodynamics simulations and modeling of percolation transition and optical properties). The theoretical work will be validated by combination of different approaches for sample fabrication and modification (thin film deposition, galvanic replacement and annealing treatments) and characterization techniques. In a second phase, the acquired knowledge will be used to devise novel infrared coatings, particularly temperature switches and ultrathin interference systems. In addition to fundamental value, the application potential of the project topic will reinforce the host institution for future industrially-oriented partnership. Finally, the project will provide opportunities to young investigators for developing a competitive research career in Croatia.]]></summary_en></project><project>
<id>9014</id><title_hr><![CDATA[Proširenje osjetilnosti senzora u laboratoriju za obradbu i analizu podataka iz okoline]]></title_hr><title_en><![CDATA[Software Sensor Augmentation at Environmental Data Analysis Laboratory]]></title_en><user_id>22609</user_id><user_firstLast_name>Hrvoje Kalinić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2019-04</proposal_call><code>UIP-2019-04-1737</code><acronim><![CDATA[SSA@EDAL]]></acronim><duration>15.02.2020 - 14.02.2025</duration><status>Završio</status><financ_value>223.805,76 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Science]]></institution_en><team_members_id>12323, 25509, 29067, 862804, 867659, 28922, </team_members_id><team_members_names><![CDATA[Martin Gregurić, Krešimir Kušić, Mladen Miletić, Leon Ćatipović, Antonio Buljan, Lea Dujić Rodić, ]]></team_members_names><keywords_hr><![CDATA[software sensor augmentation, artificial intelligence, neural networks, data reconstruction, meteorology, traffic analysis, transfer learning]]></keywords_hr><keywords_en><![CDATA[software sensor augmentation, artificial intelligence, neural networks, data reconstruction, meteorology, traffic analysis, transfer learning]]></keywords_en><summary_hr><![CDATA[U sklopu projekt bit će uspostavljen laboratorij za obradbu i analizu podataka iz okoline (EDAL). Jezgra grupe i fizički prostor će biti na Prirodoslovno-matematičkom fakultetu, a da bi se olakšala suradnja između članova tima i suradnika koji dolaze sa Sveučilišta u Zagrebu, Sveučilišta u Skopju, Instituta Ericsson Nikola Tesla i Instituta za ocenaografiju i ribarstvo, predviđen je i virtualni dio laboratorija za pohranu i razmjenu podataka. Istraživački ciljevi projekta je proučavanje modela strojnog učenja u svrhu proširenja osjetilnosti senzora. Proširenje osjetilnost senzora podrazumijeva procjenu podataka u točkama gdje (ili kada) podatci nisu mjereni, a temelji se na pretpostavci da je moguće pronaći reprezentaciju znanja koja dobro opisuje promatrani fenomen. Naučivši reprezentaciju znanja pohranjenog u podatcima to znanje možemo pohraniti ili prebaciti na drugi sustav. Na taj način drugi sustavi mogu profitirati od bolje incijalizacije i brže konvergencije ka rješenju problema. Naučena reprezentacija predstavlja komprimiranu informaciju, odnosno omogućava da se prati manja količina podataka koja nosi istu količinu informacije. Naučene reprezentacije se mogu primijeniti za rekonstrukciju podataka i tako proširiti osjetilnost senzora, što može rezultirati efikasnijim korištenjem resursa, s pozitivnim utjecajem na gospodarstvo i okoliš. Potencijalne primjene takvog osjetila mogu se predvidjeti u klasičnim sustavima za monitoring kao što je meteorologija, promet ili EU monitoring u ribarstvu. U IoT svijetu, razmjena informacija između senzora i zaključivanje na temelju podataka dobivenih iz različitih domena će prije biti pravilo, no iznimka - za što ovakvo istraživanje daje dobru podlogu.]]></summary_hr><summary_en><![CDATA[One of the project goals is to establish Environmental Data Analysis Laboratory (EDAL). EDAL core and physical space is to be located at University of Split, Faculty of Science. In order to ease cooperation with partners which come from University of Zagreb, University of Skopje, Institute Ericsson Nikola Tesla and Institute of Oceanography and Fisheries, a virtual laboratory for data storage and exchange will be organized. Scientific goals of the project assume machine learning models investigation for the purpose of software sensor augmentation (SSA). SSA denotes estimation of measurements in points where (or when) data has not been acquired, and assumes that it is possible to find knowledge representation which describes the problem well. By learning representation from the data the knowledge can be stored or transferred to another system (or problem domain). This can result in better initialization and faster convergence rate of such systems. Learned representation compresses the information and can be utilized in problems where lesser amount of data is necessary to transfer the same amount of information. Learned representation can be applied for data reconstruction and thus augment the sensor capabilities, which can result in more efficient  resource utilization with positive effects on industry and environment. Potential applications are in classical monitoring systems such as meteorology, transport or EU monitoring (e.g. of a fish stock). In IoT world, the exchange of information between sensors and inferring from data based on data from different domains is becoming a rule, rather than exception - and this research follows this direction.]]></summary_en></project><project>
<id>9017</id><title_hr><![CDATA[Koordinacijske reakcije makrocikličkih liganada u otopini]]></title_hr><title_en><![CDATA[Coordination Reactions of Macrocyclic Ligands in Solution]]></title_en><user_id>7690</user_id><user_firstLast_name>Vladislav Tomišić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-9560</code><acronim><![CDATA[MacroSol]]></acronim><duration>01.02.2020 - 31.01.2024</duration><status>Završio</status><financ_value>132.191,92 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>4270, 12733, 22634, 2558, 3260, 12384, 12766, 5334, 26870, 12769, 29449, 863818, 865152, 25323, </team_members_id><team_members_names><![CDATA[Branimir Bertoša, Nikola Bregović, Katarina Leko, Marina Tranfić Bakić, Katarina Pičuljan, Gordan Horvat, Nikola Cindro, Josip Požar, Giovanna Speranza, Renato Tomaš, Andrea Usenik, Marija Cvetnić, Matija Modrušan, Luka Fotović, ]]></team_members_names><keywords_hr><![CDATA[supramolekulska kemija, receptori, termodinamika, solvatacija, kaliksareni, ciklopeptidi, ciklodekstrini, kukurbiturili]]></keywords_hr><keywords_en><![CDATA[supramolecular chemistry, receptors, thermodynamics, solvation, calixarenes, cyclopeptides, cyclodextrins, cucurbiturils]]></keywords_en><summary_hr><![CDATA[Makrociklički spojevi zasigurno spadaju među najvažnije supramolekulske receptore aniona, kationa i neutralnih molekula. Ovaj će se projekt usmjeriti k dizajnu i sintezi brojnih takvih liganada, kao i detaljnoj fizikalno-kemijskoj karakterizaciji njihovih reakcija u otopini. Priredit će se niz derivata kaliksarena s različitim brojem supstituiranih fenolnih podjedinica. Ti će spojevi biti predvidivo vrlo efikasni i selektivni senzori za katione alkalijskih i zemnoalkalijskih metala te lantanoida, kao i raznih anionskih vrsta. Također će se istražiti reakcije receptora temeljenih na ciklodekstrinima i kukurbiturilima s različitim neutralnim supstratima. Predviđena istraživanja uključuju i veću skupinu ciklopeptida koji su prvenstveno zamišljeni kao receptori aniona. Neki od spomenutih liganada trebali bi biti iznimno osjetljivi fluorescentni senzori, a posebna pažnja bit će posvećena dizajnu receptora sa zadovoljavajućom topljivošću u vodi. Koordinacijske reakcije navedenih spojeva s raznim supstratima u nizu otapala detaljno će se proučiti sveobuhvatnim pristupom koji uključuje termodinamička, komputacijska i strukturna istraživanja. Koristit će se razne eksperimentalne metode, poput mikrokalorimetrije, UV-Vis spektrofotometrije, fluorimetrije, spektroskopije NMR, konduktometrije, potenciometrije i rentgenske strukturne analize. Receptori i njihovi kompleksi bit će također istraženi primjenom molekulske dinamike i drugih računalnih metoda. Takav pristup omogućit će pouzdano određivanje termodinamičkih veličina (konstante stabilnosti, standardne Gibbsove energije, entalpije i entropije reakcija kompleksiranja i otapanja) te dobivanje niza strukturnih informacija. Posebna će pažnja biti posvećena utvrđivanju utjecaja stvaranja vodikovih veza i solvatacije reaktanata i produkata na ravnoteže reakcija kompleksiranja. Prikupljeni termodinamički podatci trebali bi omogućiti vrlo detaljan uvid u ključne čimbenike koji određuju ravnotežni doseg istraživanih reakcija. ]]></summary_hr><summary_en><![CDATA[The efficient and selective macrocyclic receptors for charged and neutral species have played a key role in the development of supramolecular chemistry over the last few decades. This project will focus on the design and synthesis of a variety of such compounds as well as detailed physicochemical characterization of their reactions in solution. A series of calixarene derivatives with diverse number of substituted phenolic subunits will be prepared with the aim of obtaining the ligands which are capable of strongly and selectively binding alkaline, alkaline earth and lanthanide metal cations, and different kinds of anions. The receptors based on cyclodextrins and cucurbiturils and their reactions with several neutral guests will be explored as well. The investigation will also include a number of cyclopeptide derivatives primarily being designed as anion receptors. Some of the above mentioned compounds are envisaged to be highly efficient fluorescent receptors and/or to be water-soluble. The complexation abilities of all mentioned ligands towards various substrates in many solvents will be explored by using an integrated approach which includes thermodynamic, computational, and structural studies. A number of experimental methods (microcalorimetry, UV-Vis spectrophotometry, fluorimetry, NMR spectroscopy, conductometry, potentiometry, X-ray diffraction) as well as molecular dynamics and other computational techniques will be employed. Such an approach will yield detailed and reliable thermodynamic quantities (stability constants, reaction and solution Gibbs energies, enthalpies, and entropies) and the structural information regarding the receptors and their complexes. Particular attention will be paid to the hydrogen-bonding and solvent effects on the equilibria of binding reactions. The obtained thermodynamic and structural information will provide a detailed insight into the main factors governing the studied complexation processes.]]></summary_en></project><project>
<id>9020</id><title_hr><![CDATA[Odgovori smeđih algi roda Cystoseira, koje formiraju staništa, na lokalne i globalne stresore ]]></title_hr><title_en><![CDATA[The responses of habitat-forming brown macroalgae of the genus Cystoseira on local and global stressors]]></title_en><user_id>775</user_id><user_firstLast_name>Ljiljana Iveša</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-6984</code><acronim><![CDATA[HabCYS]]></acronim><duration>27.01.2020 - 26.07.2024</duration><status>Završio</status><financ_value>128.469,04 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, Interdisciplinarne prirodne znanosti, </scie_field_hr><scie_field_en>Biology, Interdisciplinary natural sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>710, 27011, 27039, 862761, 866070, 866679, </team_members_id><team_members_names><![CDATA[Massimo Devescovi, Emma Cebrian, Ezequiel Marzinelli, Andrea Bilajac, Shannen Smith, Edi Gljušćić, ]]></team_members_names><keywords_hr><![CDATA[Cystoseira, hridinasto dno, regresija, topografija, temperatura, bentoski cvat, hridinski ježinci, reproduktivna fenologija, restauracija]]></keywords_hr><keywords_en><![CDATA[Cystoseira species, rocky bottom, regression, topography, temperature, benthic mucilage, sea urchins, reproductive phenology, restoration]]></keywords_en><summary_hr><![CDATA[Sjeverni Jadran predstavlja najsjeverniji biogeografski sektor u Sredozemnom moru. Morsko dno uz zapadnu istarsku obalu uglavnom je hridinasto i stoga posebno pogodno za rast smeđih makroalgi roda Cystoseira. Zapadna obala Istre proteže se na oko 100 km zračne linije u smjeru sjever-jug. Ova posebna orijentacija utječe na veliku varijaciju oceanografskih varijabli i dinamiku valovanja. U zoni plime i oseke dominira naselje vrste Cystoseira amentacea, čija je maksimalna abundacija na jugu Istre. U predloženom projektu ispitat ćemo rasprostranjenost i gustoću naselja vrste C. amenatacea duž cijele istarske obale s posebnim osvrtom na određivanje topografije njenih staništa. Na području zapadne obale Istre zabilježena je opća regresija vrsta roda Cystoseira, prvenstveno u infralitoralnoj zoni. Prije 2015. godine, mješovita naselja smeđih makroalgi Cystoseira compressa, Cystoseira barbata, Cystoseira crinita, Cystoseira foeniculacea i Cystoseira humilis formirala su bogata staništa, koja su uglavnom dominirala na hridinastome dnu. Kronologija regresije naselja vrsta roda Cystoseira praćena je od proljeća 2015. do jeseni 2018. na nekoliko postaja. Na temelju navedenih opažanja u predloženom projektu procijenit ćemo trenutni status vrsta roda Cystoseira te moguće prve znakove regresije njihovih staništa uslijed lokalnih i globalnih stresora, među kojima ćemo veću pažnju posvetiti praćenju utjecaja povišenih ljetnih temperatura, bentoskog cvata te hridinskih ježinaca, kao brstioca. Nadalje, detaljnije ćemo ispitati reproduktivnu fenologiju vrsta roda Cystoseira, što je preduvjet za njihovu uspješnu reprodukciju te rast i razvoj, a testirat ćemo i neke ekonomski opravdane i učinkovite metode za eventualno obnavljanje nekih degradiranih staništa vrsta roda Cystoseira duž istarske obale.]]></summary_hr><summary_en><![CDATA[The northern Adriatic represents the northernmost biogeographic sector of the Mediterranean Sea. The sea bottom along the west Istrian Coast is mainly rocky and therefore particularly suitable for the growth of habitat-forming brown macroalgae of the genus Cystoseira. The west Istrian coast spans approximately 100 km air line in the north- south direction. This particular orientation produces large-scale gradients of oceanographic variables and wave action intensities.In intertidal zone Cystoseira stands were mainly composed of Cystoseira amentacea which attain maximum abundances along southern sectors of the coast. In the proposed project, we will inspect its distribution and abundance along the whole Istria Coast with special attention on determining C. amentacea habitat architecture. Starting from 2015, a general regression of Cystoseira species in subtidal zone was observed along the west Istrian Coast. Before 2015, mixed stands of Cystoseira compressa, Cystoseira barbata, Cystoseira crinita, Cystoseira foeniculacea and Cystoseira humilis formed flourishing forests, which predominantly covered the rocky bottom. The die-off chronology of Cystoseira forests was followed from spring 2015 to autumn 2018 at several stations. Based on those observations, in the proposed project we will evaluate Cystoseira current status and possible first signs of Cystoseira regression due to some local and global stressors, among which we will pay more attention to assessing the impact of high temperatures during summer, benthic mucilage formation and sea urchin grazing. Furthermore, we will inspect more in details the reproductive phenology of Cystoseira species that leads to the successful recruitment and we will test some cost-effective restoration methods for successfully restoring some degraded Cystoseira forests along the Istria coast. ]]></summary_en></project><project>
<id>9023</id><title_hr><![CDATA[Rat, žrtve, nasilje i granice slobode u hrvatskoj povijesti 20. stoljeća]]></title_hr><title_en><![CDATA[War, Victims, Violence and Borders of Freedom in the Croatian 20th Century]]></title_en><user_id>1364</user_id><user_firstLast_name>Vladimir  Gajger</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-6673</code><acronim><![CDATA[WarVic]]></acronim><duration>01.01.2020 - 31.12.2023</duration><status>Završio</status><financ_value>54.933,97 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Povijest, Interdisciplinarne humanističke znanosti, </scie_field_hr><scie_field_en>History, Interdisciplinary humanities, </scie_field_en><institution_hr><![CDATA[Hrvatski institut za povijest]]></institution_hr><institution_en><![CDATA[Croatian Institute of History]]></institution_en><team_members_id>846, 1060, 25803, 1344, 25822, 25914, </team_members_id><team_members_names><![CDATA[Martina Grahek Ravančić, Nikica Barić, Marica Karakaš Obradov, Miroslav Akmadža, Mario Kevo, Davor Marijan, ]]></team_members_names><keywords_hr><![CDATA[Hrvatska, suvremena povijest, totalitarizam, nasilje, žrtve]]></keywords_hr><keywords_en><![CDATA[Croatia, contemporary history, totalitarianism, violence, victims]]></keywords_en><summary_hr><![CDATA[Cilj projekta je istražiti kako su totalitarni-autoritarni režimi u Hrvatskoj tijekom 20 stoljeća (režim Nezavisne Države Hrvatske i režim Demokratske Federativne Jugoslavije/Federativne Narodne Republike Jugoslavije/Socijalističke Federativne Republike Jugoslavije) primjenjivali različite oblike nasilja kako bi ostvarili svoje ideološke-političke ciljeve. Projekt će se baviti razdobljem Drugoga svjetskoga rata i razdobljem od 1945. do 1990. godine. Podjednako važan cilj projekta je pobliže ustanoviti kako su na navedeno nasilje, kako bi se zaštitili i preživjeli, reagirali pojedinci i skupine  prema kojima je to nasilje bilo usmjereno. Također će se projekt baviti problemima ustanovljavanja broja, odnosno procjene žrtava Drugoga svjetskoga rata i poraća. Projekt će se znatnim dijelom temeljiti na opširnim istraživanjima neobjavljenog arhivskog gradiva. Rezultat projekta bit će, među ostalim, cijeli niz znanstvenih članaka, kao i nekoliko monografija, te održavanje niza znanstvenih kolokvija i okruglih stolova. ]]></summary_hr><summary_en><![CDATA[The goal of the project is to research how totalitarian-authoritarian regimes in Croatian during 20th century (regime of the Independent State of Croatia and regime of Democratic Federative Yugoslavia/Federative People’s Republic of Yugoslavia/Socialist Federative Republic of Yugoslavia) applied various forms of violence in order to achieve their ideological and political goals. The project will research the period of World War II and with the period from 1945 to 1990. Equally important goal is to ascertain how individuals and groups who were subjected to this violence reacted in order to protect themselves and survive. The project will also deal with the problems of establishment of numbers of certain groups of victims/casualties of World War II and immediate after war period. The project will to a large degree be based on comprehensive research of new archival sources. The project will result, among others, in series of scientific papers, monographs, and series of scientific colloquiums and round tables.   ]]></summary_en></project><project>
<id>9025</id><title_hr><![CDATA[Frustrirani Kompleksni sustavi]]></title_hr><title_en><![CDATA[Frustrated Complex Systems]]></title_en><user_id>26810</user_id><user_firstLast_name>Salvatore Marco Giampaolo</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-3321</code><acronim><![CDATA[FCS]]></acronim><duration>15.01.2020 - 31.12.2023</duration><status>Završio</status><financ_value>126.750,28 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>20277, 11143, 19411, 865299, 865286, </team_members_id><team_members_names><![CDATA[Fabio Franchini, Vinko Zlatić, Tena Dubcek, Riccarda Bonsignori, Sven Benjamin Kožić, ]]></team_members_names><keywords_hr><![CDATA[Frustracija, kompleksni sustavi, kompleksne mreže, kvantna isprepletenost, kvantna faza tvari, sistemski rizik, režim jakog grupiranja]]></keywords_hr><keywords_en><![CDATA[Frustration, Complex systems, Complex Networks, Entanglement, Quantum phase of matter, Systemic risk, Strong Clustering regime]]></keywords_en><summary_hr><![CDATA[Poznato je da frustracija, odnosno nemogućnost pronalaženja konfiguracije koja istodobno zadovoljava različita ograničenja sustava više tijela, igra ključnu ulogu u mnogim aktualnimpodručjima teorijske fizike. Međutim, unatoč toj važnosti, detaljna analiza različitih učinaka frustracije nije nikada napravljena. Naš projekt, pod nazivom &#39;&#39;Složeni frustriranisustavi&#39;&#39;, ima za cilj provesti ovu analizu u tri različita polja od iznimne važnosti za statističku fiziku: nisko-dimenzionalni spin-1/2 sustavi, kvantna termodinamika i kompleksne mreže.Koristeći nedavno razvijene analitičke alate i najmodernije numeričke simulacije, cilj našeg rada je uvođenje različitih modela u kojima se stupanj frustracije može lako kontrolirati. Utim sustavima analizirat će se kako različite količine fizičkog porijekla reagiraju na varijacije frustracije i ako se njihovo pojavljivanje može smatrati osnovom pojave / nestanka određenih karakteristika sustava. Rezultati našeg istraživanja mogli bi odigrati temeljnu ulogu u području znanstvenog istraživanja, kako s teoretskog taki i primjenjenog gledišta. U teoriji, povećati će naše razumijevanje samoorganizirajućih sustava i dovesti do otkrivanja novih uređenih faza. Oni bi također mogli biti primjenjeni na tako različite sustave kao štosu: novi uređaji za kvantni račun ili smanjenje sistemskog rizika u financijskim sustavu.]]></summary_hr><summary_en><![CDATA[It is w ell-know n that frustration, that is the impossibility of finding a configuration that simultaneously satisfies the different constraints of a many-body system, plays a key role in many fields of current interest in theoretical physics. How ever, despite this importance, a detailed analysis of the different effects of frustration has never been made. Our project, called &#39;&#39;Complex frustrated systems&#39;&#39;, aims to carry out this analysis in three different fields of extreme relevance for statistical physics: low - dimensionality spin 1/2 systems, quantum thermodynamics and complex networks. Using recently developed analytical tools and cutting-edge numerical simulations, the goal of our work is to introduce different models in which the degree of frustration can be easily controlled. In these systems it w ill be analyzed how the different quantities of physical origin respond to the variation of frustration and if the emergence of the latter can be considered the basis of the appearance / disappearance of particular characteristics of the systems. The results of our study could play a fundamental role in the field of scientific research both from a theoretical and applicational point of view. In theory, it w ill help to increase our understanding of self-organized systems and lead to the discovery of new ordered phases. They could also be applied to such diverse systems such as: new devices for quantum computation, or reduction ofsystemic risk in financial systems.]]></summary_en></project><project>
<id>9031</id><title_hr><![CDATA[Algoritmi dubokog podržanog učenja za upravljanje rizicima]]></title_hr><title_en><![CDATA[Deep Reinforcement Learning Algorithms for Risk Management]]></title_en><user_id>13406</user_id><user_firstLast_name>Zvonko Kostanjčar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-5241</code><acronim><![CDATA[DREAM]]></acronim><duration>01.02.2020 - 30.06.2024</duration><status>Završio</status><financ_value>123.432,21 eur</financ_value><scie_area_hr>Tehničke znanosti, Društvene znanosti, Prirodne znanosti, Biotehničke znanosti, Biomedicina i zdravstvo, </scie_area_hr><scie_area_en>Technological sciences, Social sciences, Natural sciences, Biotechnical sciences, Biomedicine and health sciences, </scie_area_en><scie_field_hr>Računarstvo, Matematika, Elektrotehnika, Ekonomija, Informacijske znanosti, Interdisciplinarne tehničke znanosti, </scie_field_hr><scie_field_en>Computer sciences, Mathematics, Electrical engineering, Economy, Information sciences, Interdisciplinary technological sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>7322, 20536, 733, 21046, 25649, 864841, 864992, 865163, 867517, 867518, </team_members_id><team_members_names><![CDATA[Branko Jeren, Davor Zoričić, Petra Posedel Šimović, Stjepan Begušić, Fredi Šarić, Tessa Bauman Bauman, Bruno Gašperov, Sven Goluža, Tomislav Kovačević, Andro Merćep, ]]></team_members_names><keywords_hr><![CDATA[duboko podržano učenje, kvantitativno upravljanje rizicima, duboko učenje reprezentacija, računalne financije, optimizacija portfelja]]></keywords_hr><keywords_en><![CDATA[deep reinforcement learning, quantitative risk management, deep representation learning, computational finance, portfolio optimization]]></keywords_en><summary_hr><![CDATA[Potreba za upravljanjem neizvjesnošću ishoda u procesima donošenja odluka dovela je do razvoja područja upravljanja rizicima. Tehnološki napreci i rastuća dostupnost podataka potaknuli su korištenje statističkih pristupa i kvantitativnog upravljanja rizicima u mnogim područjima, poput aktuarskih procjena, kreditnog rizika i optimizacije portfelja. Međutim, važan aspekt upravljanja rizicima – intrinzično sekvencijalna priroda problema – je zanemaren jer tradicionalne statističke metode razmatraju samo rizik jedne izolirane akcije bez uzimanja u obzir utjecaja nizova akcija na dugoročne rizike. U međuvremenu, evolucija računalne snage omogućila je uspješno korištenje složenih pristupa strojnog učenja, uključujući duboke arhitekture, u stvarnim problemima. U ovom projektnom prijedlogu, motivirani zahtjevima suvremenih scenarija upravljanja rizicima, fokusiramo se na pristup zasnovan na podržanom učenju, uzimajući u obzir neizvjesnosti budućih ishoda kao izvor rizika u problemu izravnog adaptivnog upravljanja gdje model razmatranog sustava nije potpuno poznat. Opći cilj ovog projekta je razviti novu klasu algoritama podržanog učenja osjetljivih na rizik za dinamičke okoline s primjenama u upravljanju financijskim rizicima. Konkretno, unutar predloženog projekta planiramo: (i) uključiti cilj osjetljiv na rizik u algoritme podržanog učenja temeljene na politici (ii) razviti novu klasu algoritama podržanog učenja temeljenu na aproksimaciji funkcija vrijednosti s eksplicitnim modeliranjem rizika uključenog u donošenje odluka agenta; (iii) implementirati modele reprezentacije prostora stanja koji izvlače korisne informacije iz podataka vremenskih nizova korištenjem latentnih modela; i (iv) oblikovati i implementirati metode optimizacije portfelja na temelju predloženih algoritama. Novo razvijeni algoritmi podržanog učenja poboljšat će postojeće metode i omogućiti principijelniji pristup u procesima donošenja odluka u neizvjesnim okolnostima.]]></summary_hr><summary_en><![CDATA[The need to manage uncertainty of outcomes in decision-making has given rise to the field of risk management. Advances in technology and rising availability of data have motivated the use of statistical approaches and quantitative risk management in many areas, such as actuarial assessments, credit risk, or portfolio optimization. However, an important aspect of risk management – its intrinsically sequential nature – is neglected by traditional statistical methods which only consider the risk of a single isolated action without taking into consideration the effect of sequences of actions on long-term risks. Meanwhile, the evolution of computational power has enabled the successful employment of complex machine learning approaches, including deep architectures, to real-world problems. In this project proposal, motivated by the requirements of modern risk management scenarios, we focus on a reinforcement learning based approach, by regarding the uncertainties of future outcomes as sources of risk in a direct adaptive control problem where the model of the considered system is not completely known. The overall goal of this project is to develop a novel class of risk-sensitive reinforcement learning algorithms in dynamic environments with applications in financial risk management. Specifically, within the proposed project we plan to: (1) incorporate a risk-sensitive objective in policy based reinforcement learning algorithms; (2) develop a new class of reinforcement learning algorithms based on value function approximation with explicit modeling of risk involved in agent decision making; (3) implement state space representation models that extract useful information from time series data by exploiting latent models; and (4) design and implement portfolio optimization methods based on proposed algorithms. The newly developed algorithms will ameliorate the typical flaws of the existing methods and enable decision makers to pursue a more principled approach to uncertainty.]]></summary_en></project><project>
<id>9035</id><title_hr><![CDATA[Istraživanje efikasnijeg i ekološki prihvatljivijeg izgaranja u Ottovim motorima s pretkomorom]]></title_hr><title_en><![CDATA[Research of More Efficient and Environment-Friendly Pre-Chamber Spark Ignition Combustion]]></title_en><user_id>11160</user_id><user_firstLast_name>Darko Kozarac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-4900</code><acronim><![CDATA[EF-PRECOM]]></acronim><duration>01.02.2020 - 31.07.2024</duration><status>Završio</status><financ_value>101.267,50 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, </scie_field_hr><scie_field_en>Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>13468, 13464, 26688, 864976, 865297, </team_members_id><team_members_names><![CDATA[Momir Sjerić, Rudolf Tomić, Josip Krajnović, Viktor Dilber, Sara Ugrinić, ]]></team_members_names><keywords_hr><![CDATA[pretkomora, izgaranje, učinkovitost, emisije, motor s unutarnjim izgaranjem]]></keywords_hr><keywords_en><![CDATA[pre-chamber, combustion, efficiency, emissions, internal combustion engine]]></keywords_en><summary_hr><![CDATA[Porast ekološke svijesti posljednjih godina doveo je do značajnog povećanja aktivnosti usmjerenih k smanjenju štetnog utjecaja sektora transporta, kao jednog od najvećih zagađivača, na okoliš. Električna vozila se zbog izazova s kojima se trenutno suočavaju mogu smatrati tek dugoročnim rješenjem dok, s obzirom na sve izraženije posljedice globalnog onečišćenja, postoji potreba za rješenjima koja će barem djelomično ublažiti štetne učinke, a mogu se primijeniti u mnogo kraćem vremenskom okviru. Posljednja istraživanja ukazuju kako Ottovi motori s pretkomorom predstavljaju jednu od ključnih tehnologija u ostvarivanju tih ciljeva. Ipak, dosadašnja istraživanja još uvijek nisu u potpunosti odgovorila na sve izazove za masovnu primjenu ove tehnologije u cestovnim vozilima. Iz pregleda literature identificirana su glavna područja od interesa, u skladu s čime su formirani ciljevi istraživanja. Za pogon benzinom ispitat će se utjecaj volumena i geometrije pretkomore uz zadržavanje konstantne energije goriva u pretkomori te istražiti mogućnost primjene naprednog načina izgaranja (PCHCCI) za poboljšanje rada motora. Za pogon prirodnim plinom ispitat će se primjena i utjecaj povrata ispušnih plinova te različite strategije ispiranja pretkomore što se pokazalo kao jedna od značajnijih problematika u Ottovim motorima s pretkomorom. Prije navedenih ispitivanja modificirati će se i unaprijediti trenutni eksperimentalni postav kako bi se omogućio rad motora s pretkomorom te sva potrebna mjerenja. Glavna svrha ovog istraživanja je temeljitim eksperimentalnim ispitivanjima potpomognutim naprednim numeričkim simulacijama i proračunima, a usmjerenim na dosad neodgovorena pitanja i izazove, dati znanstveni doprinos u istraživanju efikasnijeg i ekološki prihvatljivijeg načina izgaranja u Ottovim motorima te postići dodatni iskorak u pronalasku rješenja za smanjenje globalnog onečišćenja na dobrobit okoliša i cjelokupnog čovječanstva.]]></summary_hr><summary_en><![CDATA[Increased environmental awareness in recent years has led to a significant increase in the activities aimed at reducing the negative impact of the transport sector, as one of the largest polluters, on the environment. Electric vehicles, because of the challenges they currently face, can be considered only as a long-term solution while, given the pronounced effects of global pollution, there is a need for solutions that will at least partially mitigate harmful effects in a much shorter time frame. Recent research indicates that pre-chamber (PC) SI engines represent one of the key technologies in achieving those goals. However, investigations have not yet fully responded to all the challenges for mass application of this technology in road vehicles. From the literature review the main areas of interest are identified, in accordance with which the research objectives were formed. For operation with gasoline the influence of volume and geometry of the PC with constant energy of the fuel in the PC will be examined and the possibility of applying advanced combustion mode (PCHCCI) to improve the operation of the engine will be explored. For operation with natural gas the application and impact of EGR will be examined, as well as different strategies for PC scavenging, which proved to be one of the most important topics in such engines. Prior to the above tests it is necessary to modify and improve the current experimental set-up in order to enable the operation of the engine with PC, as well as all the necessary measurements. The main purpose of this research is to give a scientific contribution in the research of more efficient and environment-friendly combustion by thorough experimental studies, assisted by advanced numerical simulations and calculations directed to unanswered questions and challenges, thus achieving an additional step forward in finding solutions to reduce global pollution for the environment and to improve human life.]]></summary_en></project><project>
<id>9039</id><title_hr><![CDATA[Biodostupnost karotenoida kukuruza kod nesilica: utjecaj mikrostrukture zrna i sastava smjese]]></title_hr><title_en><![CDATA[Bioavailability of maize carotenoids in laying hens: Effect of grain microstructure and diet composition]]></title_en><user_id>21438</user_id><user_firstLast_name>Kristina Kljak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-9063</code><acronim><![CDATA[ColourMaize]]></acronim><duration>15.01.2020 - 14.01.2024</duration><status>Završio</status><financ_value>199.065,21 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, Nutricionizam, Interdisciplinarne biotehničke znanosti, </scie_field_hr><scie_field_en>Agriculture, Nutrition, Interdisciplinary biotechnical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Agronomski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Agriculture]]></institution_en><team_members_id>7806, 26998, 26966, 26970, 27018, 27255, 12377, 27226, 855936, 865277, </team_members_id><team_members_names><![CDATA[Darko Grbeša, Zlatko Janječić, Goran Kiš, Dalibor Bedeković, Marija Duvnjak, Zlatko Svečnjak, Zlata  Kralik, Vasil Pirgozliev, Dora Zurak, Veronika Gunjević, ]]></team_members_names><keywords_hr><![CDATA[karotenoidi, zrno kukuruza, hibridi kukuruza, bioraspoloživost, biodostupnost, nesilice, žumanjak jajeta, fizikalno-kemijska svojstva, sastav smjese]]></keywords_hr><keywords_en><![CDATA[carotenoids, maize grain, maize hybrids, bioaccessibility, bioavailability, laying hens, egg yolk, physicochemical traits, diet composition]]></keywords_en><summary_hr><![CDATA[Žumanjak jajeta se smatra bogatim izvorom žutih pigmenata luteina i zeaksantina, spojeva iz skupine karotenoida važnih za zdravlje očiju i antioksidacijsku zaštitu ljudskog organizma. Karotenoidi jajeta potječu samo iz hrane jer ih kokoši nesilice ne mogu sintetizirati. Zrno kukuruza je jedina žitarica koja sadrži značajne količine karotenoida, među kojima najviše ljudima potrebnih luteina i zeaksantina. Zbog visokog udjela zrna u hrani nesilica, oni mogu ne samo doprinijeti već i biti jedini izvor pigmenata za poželjnu boju žumanjka jajeta. Međutim, sadržaj i vjerojatno iskoristivost karotenoida su određeni genotipom kukuruza. Generalno, sva prisutna količina karotenoida hrane nije bioraspoloživa jer se iz matrice hrane samo dio oslobodi tijekom probave te je dostupan za apsorpciju, metabolizam i ugradnju u jaja (biodostupnost). Matrice potpune hrane nesilica i zrna su dva glavna čimbenika koji utječu na bioraspoloživost i biodostupnost karotenoida iz zrna kukuruza. Obilježja zrna kukuruza povezana s mikrostrukturom endosperma su kao i sadržaj karotenoida genetski uvjetovani te će se predloženim istraživanjem povezati bioraspoloživost karotenoida određena in vitro metodama te biodostupnost određena u pokusu s nesilicama i fizikalno-kemijska obilježja zrna najzastupljenijih hibrida kukuruza u RH. Zatim će se utjecaj obrade zrna – temperatura sušenja nakon berbe i veličina čestice meljave, i promjene sastava potpunih krmnih smjesa – različite razine dodatka repičinog ulja, lecitina i vitamina A te forme dodatka mikrominerala na biodostupnost karotenoida odrediti u tri hranidbena pokusa s nesilicama hranjenih smjesama s dva hibrida kukuruza divergentne biorasploživosti određene u prethodnom pokusu. Bioraspoloživost i biodostupnost karotenoida iz zrna kukuruza do sada nisu istraživane te bi poznavanje čimbenika koji na njih utječu omogućilo njihovo bolje iskorištenje u pigmentaciji peradi te odabir i proizvodnju hibrida boljih pigmentacijskih svojstava.]]></summary_hr><summary_en><![CDATA[Egg yolk is considered a rich source of yellow pigments lutein and zeaxanthin, carotenoid compounds important for eye health and antioxidant protection of the human body. Egg carotenoids are from dietary intake since laying hens can not synthesize them. Maize grain is the only cereal with significant content of carotenoids, mostly for humans important lutein and zeaxanthin. Due to the high proportion of grain in hens diet, they can contribute, but also be the only source of pigments for desirable egg yolk colour. However, the content and likely utilization of carotenoids are determined by maize genotype. Generally, all present carotenoid amounts in the diet are not bioaccessible as only a fraction is released from matrix during digestion and is available for absorption, metabolism and egg deposition (bioavailability). Matrices of laying hens diet and grain are two main factors affecting bioaccessibility and bioavailability of maize carotenoids. Maize grain traits associated with the endosperm microstructure are, as well as the carotenoid content, genetically determined, and proposed research will relate bioaccessibility of carotenoids determined using in vitro methods and bioavailability determined in hen trials with physicochemical traits of the most common maize hybrids in Croatia. Then, the effect of grain processing – the drying temperature and the grinding particle size, and changes in the diet composition – different supplementation levels of rapeseed oil, lecithin, and vitamin A, and micromineral form, on in vivo bioavailability of maize carotenoids will be investigated in three trials with hens fed diets based on two hybrids of diverse bioavailability selected in previous trial. Bioaccessibility and bioavailability of maize grain carotenoids have not been studied so far, and knowing the factors influencing them will allow better utilization of carotenoids for poultry pigmentation and the selection and production of hybrids of higher pigmentation properties.]]></summary_en></project><project>
<id>9046</id><title_hr><![CDATA[Primjena naprednih tehnologija obrade voda za uklanjanje mikroplastike]]></title_hr><title_en><![CDATA[Advanced Water Treatment Technologies for Microplastics Removal]]></title_en><user_id>1298</user_id><user_firstLast_name>Tomislav Bolanča</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-9661</code><acronim><![CDATA[AdWaTMiR]]></acronim><duration>15.12.2019 - 14.12.2023</duration><status>Završio</status><financ_value>118.455,11 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Interdisciplinarne tehničke znanosti, Kemijsko inženjerstvo, </scie_field_hr><scie_field_en>Interdisciplinary technological sciences, Chemical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet kemijskog inženjerstva i tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Chemical Engineering and Technology]]></institution_en><team_members_id>26761, 20202, 2711, 4661, 4216, 20206, 25625, 27210, 3296, 20261, 20856, 27217, 4429, 27259, 856187, 864972, 29635, 864974, 29641, </team_members_id><team_members_names><![CDATA[Laszlo Sipos, Davor Dolar, Marinko Markić, Šime Ukić, Danijela Ašperger, Krešimir Košutić, Dajana Kučić Grgić, Martina Miloloža, Vesna Ocelić Bulatović, Marko Racar, Matija Cvetnić, Miroslav Slouf, Magdalena Ujević Bošnjak, Matthias Zessner, Kristina Bule, Viktorija Prevarić, Silvia Morović, Iva Ćurić, Bruna Babić, ]]></team_members_names><keywords_hr><![CDATA[onečišćene vode, mikroplastika, uklanjanje, napredne tehnologije obrade, inovativni reaktor]]></keywords_hr><keywords_en><![CDATA[contaminated water, microplastics, removal, advanced treatment technologies, inovative reactor]]></keywords_en><summary_hr><![CDATA[U današnje vrijeme ljudi postaju svjesni problema prisutnosti mikroplastike (MP) u okolišu. Zbog veličine čestica (< 5 mm), organizmi ju znatno lakše unose u sebe. Na taj se način povećava njihova izloženost plastici, što može imati neželjene zdravstvene posljedice. Dosadašnje studije uklanjanja MP-a iz voda su relativno rijetke i oskudne pa je glavni cilj AdWaTMiR-a upravo razvoj novih inovativnih metodologija obrade MP-a u vodama te izrada i potvrđivanje rezultata u novoizrađenom prototipu reaktora za uklanjanje. Razvijeni procesi odlikovati će se tehnološkom učinkovitoću, ekološkom prihvatljivošćui i ekonomskom opravdanošću, bit će održivi i kompatibilni principima kružne ekonomije.Istraživanja vezana za AdWaTMiR odvijat će se kroz 6 cjelina:1.	Priprema MP standarda 2.	Razvoj analitičkih metoda za određivanje MP-a u vodi3.	Biorazgradnja MP-a u vodenim suspenzijama4.	Degradacija MP-a u vodenim suspenzijama pomoću AOP-a5.	Uklanjanje MP-a iz vodenih suspenzija membranskim postupcima 6.	Spajanje MBR sustava s AOP-ovima u inovativnom reaktorskom sustavuHipoteze projekta su:1.	Napredni procesi biorazgradnje su učinkovit pristup uklanjanju MP-a iz vode.2.	AOP je učinkovit pristup uklanjanju MP-a iz vode.3.	AOP-MBR spajanje je učinkovitije od ostalih dvaju MP tretmana.AdWaTMiR je fokusiran na postizanje kratkoročnih politika Europske komisije u dijelu razvoja novih tehnologija i zaštite okoliša, koje moraju biti održive, energetski učinkovite, usklađene s paradigmom kružne ekonomije, te dugoročnih politika vezanih uz klimatske promjene. Osim šireg društvenog konteksta, ekonomski će se očitovati u mogućoj brzoj implementaciji novorazvijenih inovativnih tehnologija visoke dodane vrijednosti, unutar industrije i javnih tvrtki s izrazito brzim povratima investicija i blagotvornim financijskim efektima. Znanja dobivena ovim projektom biti će podloga za daljnja znanstvena i stručna istraživanja te uspostavu novih istraživačkih grupa kako unutar RH tako i na prostoru EU.]]></summary_hr><summary_en><![CDATA[Presence of small plastic particles (< 5 mm) in environment has gain increasing attention in recent years. These microplastics (MP) can be ingested more readily. The ingestion increases chemical exposure and, thus, might cause unwanted health problems.Studies dealing with MP removal from water are so far relatively rare and scarce. Therefore, the main goals of AdWaTMiR are development of innovative methodologies for MP removal from water suspensions and design of newly constructed reactor prototype for related MP removal. Developed processes will be distinguished by technological efficiency, environmental acceptability and economic feasibility, and will be sustainable and compatible with principles of the circular economy.AdWaTMiR research will have six phases:1.	Preparation of MP standards2.	Development of methods for MP determination in water3.	MP biodegradation in suspensions4.	MP degradation in suspensions by AOPs 5.	MP removal from suspensions by membrane processes 6.	Coupling of MBR system with AOPs in innovative reactor Project hypotheses are:1.	Advanced microbiological processes are an effective approach in removal of MP from water.2.	AOP is an effective approach in removal of MP from water.3.	AOP-MBR coupling is more effective than other two MP treatments by means of selected optimization criteria.AdWaTMiR is focused on achieving short-term policies of the EU Commission in area of new technologies development and environmental protection (which must be sustainable and energetically efficient) and long-term policies related to climate changes. In addition to broader social context, possible rapid implementation of newly developed high value-added technologies will be economically evident within industries and public companies with fast investment-returns and beneficial financial effects. Knowledge gained by the project will be basis for further scientific and professional researches and for establishment of new research groups, within Croatia and abroad.]]></summary_en></project><project>
<id>9048</id><title_hr><![CDATA[Isplati li se transparentnost? Politički i socioekonomski učinci transparentnosti proračuna lokalnih jedinica  u Hrvatskoj]]></title_hr><title_en><![CDATA[Does Transparency pay-off? The political and socio-economic impacts of local government budget transparency in Croatia]]></title_en><user_id>2677</user_id><user_firstLast_name>Mihaela Bronić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-8360</code><acronim><![CDATA[IMPACTBT]]></acronim><duration>03.01.2020 - 02.01.2024</duration><status>Završio</status><financ_value>89.256,09 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, </scie_field_hr><scie_field_en>Economy, </scie_field_en><institution_hr><![CDATA[Institut za javne financije]]></institution_hr><institution_en><![CDATA[Institute of Public Finance]]></institution_en><team_members_id>13372, 13295, 25875, 25362, 861755, 21290, 864984, </team_members_id><team_members_names><![CDATA[Katarina Ott, Velibor Mačkić, Paulo Mourao, Simona Prijaković, Marija Opačak, Branko Stanić, Maria-Dolores Guillamon, ]]></team_members_names><keywords_hr><![CDATA[lokalne jedinice, transparentnost proračuna, Indeks otvorenosti lokalnih proračuna, Hrvatska, politički i socio-ekonomski učinci]]></keywords_hr><keywords_en><![CDATA[Local government, budget transparency, Open local budget index, Croatia, political and socio-economic impacts]]></keywords_en><summary_hr><![CDATA[Transparentnost proračuna lokalnih jedinica (TPLJ) podrazumijeva uvid u potpune, točne, pravovremene i razumljive informacije o proračunima lokalnih jedinica (Ott, Bronić, Petrušić i Stanić, 2018.). Važna je za sve građane, jer uplaćuju poreze u proračune lokalnih jedinica (LJ) i koriste se njihovim uslugama. Pristup informacijama i transparentnost mogu se smatrati i ljudskim pravom jer je općeprihvaćeno temeljno pravo znati što država radi i zašto (Kaufmann i Bellver, 2005.). Fiskalna/proračunska transparentnost može potaknuti preraspodjelu i uključivost, pomoći građanima da bolje razumiju i nadziru lokalne proračune, plaćaju niže poreze i dobiju efikasnije lokalne usluge (npr. škole ili ceste).Fiskalna/proračunska transparentnost jedna je od ključnih tema suvremenih istraživanja političke ekonomije i javne uprave, uz temeljnu pretpostavku da se njome osigurava odgovornost. Ipak, još uvijek nema dovoljno spoznaja o načinu kako transparentnost utječe na odgovornost i poboljšava kvalitetu upravljanja (Kaufmann i Bellver, 2005.), posebice na lokalnim razinama. Nedostatak podataka za dulja vremenska razdoblja vjerojatno je jedan od glavnih razloga za izostanak ovih istraživanja. Zahvaljujući prethodnom projektu HRZZ-a, Institut za javne financije od 2015. godišnje mjeri transparentnost proračuna svih 576 hrvatskih lokalnih jedinca i to planira nastaviti. Kako ni jedno drugo istraživanje nije tako dugo i kontinuirano mjerilo TPLJ, dostupnost podataka za čak deset godina, pružila bi nam jedinstvenu priliku, uz pomoć linearnih i nelinearnih panel modela, za utvrđivanje dugoročnih učinaka TPLJ na razinu lokalnih rashoda, deficit, dug i rezultate izbora. Tako bi se mogla popunit praznina u postojećim znanjima i znanstvenoj literaturi.Svrha projekta je istražiti: Isplati li se TPLJ u Hrvatskoj? Koji su politički i socioekonomski učinci povećanog TPLJ-a u Hrvatskoj? Kako i kada TPLJ u Hrvatskoj pridonosi ishodima koje kreatori politika, istraživači i građani žele postići?]]></summary_hr><summary_en><![CDATA[Local budget transparency (LBT) implies the insight into complete, accurate, timely and understandable local budget information (Ott, Bronić, Petrušić & Stanić, 2018). It is important to all citizens as they are all paying local taxes and using local services. Access to information and transparency can also be considered as the human right, i.e. a basic right to know what the government is doing and why (Kaufmann & Bellver, 2005). LBT is also critical for development as it provides incentives for redistribution and inclusiveness, has the potential to help citizens to understand and control local government (LG) budgets, reduce the local tax burden and provide more efficient public services (e.g. schools). Fiscal/budget transparency has become on of the key topics of contemporary research in political economy and public administration, with underlying assumption that it produces accountability, but with poor understanding of how it affects accountability and improves the quality of governance (Kaufmann & Bellver, 2005). That is especially true for local level. One of the reasons for scarce research on impacts of LBT might be the lack of longer time series of data. Thanks to the previous CSF project, Institute of Public Finance has since 2015 measured annually LBT for all 576 Croatian LGs and it will continue measuring it. As there is no known other measurements of LBT for such a long period, the availability of the data for up to ten years, would give us the unique opportunity, by using linear and nonlinear panel models, to investigate the long-term impacts of LBT on the LGs’ level of expenditures, deficit, debt and election results. Thus, it might be possible to fill gap in the existing knowledge and literature. The project on LBT in Croatia intends to answer: Does it really pay-off? What are the political and socio-economic impacts of its improvements? How and in what circumstances, it might contribute to outcomes desired by policy makers, researchers and citizens?]]></summary_en></project><project>
<id>9058</id><title_hr><![CDATA[Regulacija popravka dvolančanog loma u genomu bakterije Escherichia coli]]></title_hr><title_en><![CDATA[Regulation of DNA double-strand break repair in Escherichia coli]]></title_en><user_id>5308</user_id><user_firstLast_name>Damir Đermić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-3790</code><acronim><![CDATA[DNARegPop]]></acronim><duration>15.03.2020 - 14.08.2024</duration><status>Završio</status><financ_value>128.177,05 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>5202, 12366, 4407, 559, </team_members_id><team_members_names><![CDATA[Davor Zahradka, Siniša Ivanković, Edyta Đermić, Isidoro Feliciello, ]]></team_members_names><keywords_hr><![CDATA[dvolančani lom u DNA, homologna rekombinacija, popravak DNA, enzim RecBCD, egzonukleaze, protein SSB]]></keywords_hr><keywords_en><![CDATA[DNA double-strand break, homologous recombination, DNA repair, RecBCD enzyme, exonucleases, SSB protein]]></keywords_en><summary_hr><![CDATA[Dvolančani lom u molekuli DNA (DL)  je letalan ako se ne popravi, a njegov neprecizni popravak dovodi do mutacija i genomskih rearanžmana, što kod ljudi može uzrokovati nastanak raka i prerano starenje. Popravak DL-a je evolucijski konzerviran pa se proučava na modelnim organizmima kao što je bakterija Escherichia coli. DL se u bakteriji E. coli popravlja procesom homologne rekombinacije (HR), kopiranjem s intaktne homologne regije.  HR-u vrši jednolančana regija s 3&#39;-krajem, koja nastaje uklanjanjem komplementarnog lanca procesom nazvanim resekcija DL-a. Resekciju u bakteriji E. coli vrši helikaza/nukleaza RecBCD, koja odvija DNA i degradira oba odvijena lanca. Interakcijom sa slijedom Chi u procesiranoj DNA RecBCD prekida degradaciju lanca s 3'-krajem, te na njega polimerizira rekombinazu RecA. Ovaj projekt se bavi dosad nekarakteriziranim aspektima popravka DL-a u bakteriji E. coli. Koristeći genetičke, molekularnobiološke i bioinformatičke metode, proučavati ćemo sintezu i ulogu esencijalnog proteina SSB u popravku DL-a, posebno pri ilegitimnoj rekombinaciji. Također, nastavit ćemo naše proučavanje uloge egzonukleaza u popravku DL-a, a i njihove filogenetske odnose i distribuciju u bakterijama. Uz to, utvrditi ćemo da li se obrada DL-ova u bakteriji E. coli vrši jednokratnim ili višekratnim vezanjem helikaza na krajeve DNA, te također ulogu proteina RecA u interakciji RecBCD-a sa slijedom Chi. Od projekta se očekuje da produbi spoznaje o mehanizmima regulacije popravka DL-ova u genomu bakterije E. coli. S obzirom na konzerviranost popravka DL-a, ovo istraživanje može imati medicinski značaj u smislu razvoja spoznaja o nastanku raka i njegovom liječenju. Medicinsko značenje projekta može proizaći i iz boljeg razumijevanja bakterijskih obrambenih mehanizama pri interakciji s ljudskim domaćinom, koji utječu na bakterijsku patogenost i otpornost na antibiotike.]]></summary_hr><summary_en><![CDATA[DNA double-strand break (DSB) is a lethal lesion if left unrepaired, whereas its imprecise repair yields mutations and genomic rearrangements, which in humans may cause cancer and premature ageing. DSB repair is an evolutionary conserved process and hence is studied using model organisms, such as Escherichia coli. In E. coli, a process named homologous recombination (HR), wherein an intact homologous sequence serves as a template, repairs a DSB. HR is effected by a 3’-ovehang, which is produced by degrading its complementary 5’-ending strand in a process called DSB resection. Resection in E. coli is catalyzed by a RecBCD helicase/nuclease, which unwinds DNA and degrades both the unwound strands. Upon its interaction with Chi sequence of the processed DNA, RecBCD ceases degradation of the 3’ strand and starts loading RecA recombinase onto it. This project deals with some yet uncharacterized aspects of DSB repair in E. coli, using genetic, molecular biology and bioinformatics methods. We plan to determine production and the role of SSB, an essential protein, in DSB repair, specifically in illegitimate recombination. In addition, we will continue our studies of the role of exonucleases in E. coli DSB repair, as well as their phylogenetic relations and distribution in bacteria. Moreover, we plan to explore whether DSB processing in E. coli is achieved by a single or multiple rounds of helicase loading onto DNA ends, and additionally, what is the role of RecA protein in RecBCD interaction with Chi sequence. The project envisages a fundamental research that due to conserved mechanisms of DSB repair may have a medical relevance in a sense of deepening our insight into origins of cancer and the means to treat it. Another medical aspect of the project stems from better characterization of bacterial defense mechanisms involved in bacterial interaction with their human host, having repercussion on their pathogenicity and resistance to antibiotics.]]></summary_en></project><project>
<id>9061</id><title_hr><![CDATA[Genetski i epigenetski biljezi kao pokazatelji agresivnosti diferenciranog karcinoma štitnjače]]></title_hr><title_en><![CDATA[Genetic and epigenetic markers as indicators of aggressiveness of differentiated thyroid cancer]]></title_en><user_id>702</user_id><user_firstLast_name>Zvonko Kusić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-1130</code><acronim><![CDATA[ThyroGeneMark]]></acronim><duration>01.01.2020 - 31.03.2024</duration><status>Završio</status><financ_value>100.232,26 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Kliničke medicinske znanosti, Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Clinical sciences, Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Klinički bolnički centar "Sestre Milosrdnice", Zagreb]]></institution_hr><institution_en><![CDATA[Clinical Hospital Center "Sestre Milosrdnice", Zagreb]]></institution_en><team_members_id>5717, 5473, 5465, 5466, 6138, 5582, 5794, 6727, 6697, 5614, 24169, 23652, 24215, 24167, 26276, 26543, 22759, 396, 5734, 25371, 25811, 6462, 7245, 26441, 5561, 6104, 5764, 27156, 864844, 587, 19540, 865574, </team_members_id><team_members_names><![CDATA[Maja Franceschi, Tomislav Jukić, Josip Stanicic, MARIJA PUNDA, Ines  Šiško Markoš, Petra Petranović Ovčariček, Valentina Vidranski, Vedrana Gladić Nenadić, Ivan Jakšić, Roko Granić, Marija Bosak Butković, Ivan Blažeković, Tea Varjačić, Matija Romić, josipa Periša, Sanja Tadinac, Tihana Regović Džombeta, Ivan Šamija, Neven Mateša, Dora Raos, Valdi Pešutić-Pisac, Ivan Mihaljević, Jasmina  Rajc, Željko Zubčić, Nina Dabelić, Vladimir Bedeković, Dražena Krilić, Davor Vagić, Nikola Kolja Poljak, Nikolina Basic-Jukic, Petra Radulović, Dorotea Filipan, ]]></team_members_names><keywords_hr><![CDATA[karcinom štitnjače, BRAF, TERT, Ki67,metilacija DNA]]></keywords_hr><keywords_en><![CDATA[thyroid cancer, BRAF, TERT, Ki67, DNA methylation]]></keywords_en><summary_hr><![CDATA[Karcinom štitnjače unatoč svojem pretežito indolentnom toku predstavlja značajno opterećenje zdravstvenom sustavu svojom visokom incidencijom. Recentne publikacije ističu potrebu za napretkom u molekularnoj dijagnostici u svrhu otkrivanja biljega prognostičkog značenja za agresivnost bolesti koja se očituje recidivom ili perzistencijom bolesti, razvojem regionalnih i udaljenih metastaza ili refrakternošću na danas prihvaćenu terapiju radiojodom. Predloženi projekt nastoji istražiti utjecaj i korist analize BRAF i TERT mutacije te epigenetskih promjena TERT sekvence u bolesnika u odnosu s pokazateljima agresivnosti diferenciranog karcinoma štitnjače. Područje epigenetskih modifikacija u procesu nastanka bolesti je vrlo slabo istraženo te je analiza epigenetskih promjena jedan od bitnih prednosti predloženog projekta. Potvrdom korisnosti ovih biljega agresivnosti uvela bi se rutinska primjena određivanja navedenih biljega kod oboljelih od diferenciranih karcinoma štitnjače u kliničku praksu s ciljem rane selekcije bolesnika koji zahtijevaju daljnje liječenje, dijagnostiku i praćenje te u budućnosti eventualnu selekciju bolesnika za terapiju inhibitorima B-RAF-a. Uspješnom provedbom ovog projekta otvorio bi se novi smjer molekularne dijagnostike u Hrvatskoj za karcinome štitnjače te doprinijelo razvoju međunarodnih smjernica za selekciju ovih učestalih i potencijalno opasnih karcinoma. Klinika za onkologiju i nuklearnu medicinu kao Referentni centar za bolesti štitnjače Ministarstva zdravlja RH ovim nastoji otvoriti nove poglede na dugogodišnji zdravstveni problem te usmjeriti svoj znanstveni rad u trenutno najaktualnije područje dijagnostike i liječenja karcinoma štitnjače.]]></summary_hr><summary_en><![CDATA[Thyroid carcinoma, despite its predominantly indolent course, represents a significant burden on the health system with its high incidence. Recent publications emphasize the need for advancement in molecular diagnostics for the purpose of detecting a new markers of prognostic significance for the aggressiveness of the disease that is characterized by recurrence or persistence of the disease, the development of regional and distant metastases or the resistance on today&#39;s accepted radioiodine theraphy. The proposed project seeks to explore the benefit of BRAF and TERT mutation analysis and the epigenetic changes in the TERT sequence in patients in relation to the aggressiveness of differentiated thyroid carcinoma. The field of epigenetic modifications in the disease pathophysiology is poorly investigated and the analysis of epigenetic changes is one of the important advantages of the proposed project. By confirming the usefulness of these markers, routine analysis of said markers in patients with differentiated thyroid carcinoma would be introduced in clinical practice in order to provide early selection of patients requiring further treatment, diagnosis and monitoring and possibly for selection of patients suitable  for therapy with B-RAF inhibitors in future. The successful implementation of this project would open a new direction for molecular diagnostics in Croatia for thyroid carcinoma and contribute to the development of international guidelines for the selection of these common and potentially dangerous carcinoma. The Clinic for Oncology and Nuclear Medicine as the Reference Center for thyroid diseases of the Ministry of Health of the Republic of Croatia with this project aims to open new views on the longstanding health problem and to direct its scientific work into the most current field of diagnostics and treatment of thyroid cancer.]]></summary_en></project><project>
<id>9066</id><title_hr><![CDATA[Uloga lova i lovnog gospodarenja u širenju novonastalih populacija divljih papkara na Mediteranu]]></title_hr><title_en><![CDATA[The role of hunting related activities in the range expansion of recently established wild ungulate populations in the Mediterranean]]></title_en><user_id>19869</user_id><user_firstLast_name>Toni Safner</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-4096</code><acronim><![CDATA[MedUng]]></acronim><duration>15.01.2020 - 14.01.2024</duration><status>Završio</status><financ_value>98.812,13 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Agronomski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Agriculture]]></institution_en><team_members_id>25981, 26055, 2566, 3919, 27243, 2954, 25111, 19944, 865269, </team_members_id><team_members_names><![CDATA[Massimo Scandura, Alain Frantz, Keros Tomislav, Dean Konjević, KREŠIMIR KAVČIĆ, Nikica Šprem, Sunčica Stipoljev, Elena Bužan, Mihael Janječić, ]]></team_members_names><keywords_hr><![CDATA[Introdukcije, MHC, adaptabilnost, invazivnost, papkari, Grivasti skakač, Europski muflon, divlja svinja]]></keywords_hr><keywords_en><![CDATA[Introductions, MHC, adaptability, invasiveness, ungulates, aoudad, European mouflon, wild boar]]></keywords_en><summary_hr><![CDATA[Translokacije papkara u svrhu introdukcije, reintrodukcije ili nadomještanja su uglavnom motivirane lovom. Divljač se uobičajeno introducira u nova staništa kako bi se stvorile nove ili poboljšale postojeće prilike za lov, pogotovo kada se smanji brojnost autohtonih lovnih vrsta. Introducirane vrste mogu postati invazivne, pa je radi toga važno proučiti njihov utjecaj na staništa i prisutne autohtone vrste (moguću kompeticiju, prijenos uzročnika bolesti, hibridizaciju ili izmjenu staništa). U ovom istraživanju će se, kombinacijom najnovijih istraživačkih metoda iz različitih područja (genetike, genomike, biokemije, bioinformatike, GPS slijeđenja i parazitologije) prikazati detaljna slika učinka translokacija triju vrsta papkara. Grivasti skakač i europski muflon introducirane su vrste na području mediterana, dok su divlje svinje nedavno uspostavile nove populacija na nekim otocima kroz procese prirodne kolonizacije ili kroz nelegalne translokacije u svrhu lova. Integracijom podataka o neutralnim (mikrosateliti) i svojstvima povezanim sa fitnesom (MHC geni) razviti ćemo protokol koji će omogučiti procjenu statusa novonastalih populacija papkara i utjecaj aktivnosti povezanih s lovom na njihovo širenje. Ovaj pristup biti će polazište za daljna istraživanja selekcijskih procesa u izmijenjenim staništima i promjena ponašanja populacija koje se suočavaju s izmjenama u njihovim staništima. Ta saznanja su važna za razumijevanje načina na koji se divlje, ali i domaće, životinjske vrste prilagođavaju promjenama u okolišu, što je posebno važna tema u ozračju očekivanih promjena prirodnih uvjeta uvjetovanih klimatskim promjenama.  ]]></summary_hr><summary_en><![CDATA[Translocation of ungulate species with purpose of introduction, re-introduction or supplementation is mostly motivated by hunting. Wildlife is commonly introduced in new habitats to create or improve hunting opportunities, especially when native game species have become scarce. Since introduced species can become potential invaders, it is thus important to study their influence on habitat and native species (possible competition, transmission of pathogen, hybridization or habitat alteration). In this research, we will implement cutting edge research methodology in different fields (genetics, genomics, biochemistry, bioinformatics, GPS tracking and parasitology) and combine them to draw a detailed picture of translocation history for three ungulate species. Aoudad and European mouflon are introduced species in Mediterranean Europe, while wild boar recently established new populations on some islands through natural colonization or illegal translocations for hunting purposes. By integrating information on neutral and fitness-related traits, we will develop a protocol which will provide a comprehensive way to assess the status of non native populations and possible influence of hunting related activities to their expansion. Such approach will constitute the starting point for additional researches targeting selection processes in transformed landscapes and behavioral changes in populations facing alterations to their habitat. All these aspects are fundamental to understand how wild, but also domestic, species will adapt to changes in their environment, an aspect of increasing importance considering the alteration of natural conditions due to climate change.]]></summary_en></project><project>
<id>9068</id><title_hr><![CDATA[Sintaktička i semantička analiza dopuna i dodataka u hrvatskom jeziku]]></title_hr><title_en><![CDATA[Syntactic and Semantic Analysis of Arguments and Adjuncts in Croatian]]></title_en><user_id>19124</user_id><user_firstLast_name>Matea Andrea Birtić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-7896</code><acronim><![CDATA[SARGADA]]></acronim><duration>01.02.2020 - 31.01.2024</duration><status>Završio</status><financ_value>45.748,62 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filologija, Interdisciplinarne humanističke znanosti, </scie_field_hr><scie_field_en>Philology, Interdisciplinary humanities, </scie_field_en><institution_hr><![CDATA[Institut za hrvatski jezik]]></institution_hr><institution_en><![CDATA[Institute of Croatian Language]]></institution_en><team_members_id>2892, 2905, 23390, 23381, 23866, 23362, 19309, 27334, </team_members_id><team_members_names><![CDATA[Ivana Brač, Siniša Runjaić, Branimir Belaj, Irena Zovko Dinković, Ismail Palić, Mia Batinić Angster, Iva Nazalević Čučević, Ana Werkmann Horvat, ]]></team_members_names><keywords_hr><![CDATA[sintaksa, semantika, dopuna, dodatak, hrvatski jezik]]></keywords_hr><keywords_en><![CDATA[syntax, semantics, argument, adjunct, Croatian]]></keywords_en><summary_hr><![CDATA[Temeljni je cilj projekta precizno definirati kriterije za razlikovanje dopuna i dodataka u hrvatskom jeziku s teorijske i primijenjene strane. Teorijska strana projekta uključit će iscrpnu analizu pristupa dopunama i dodatcima unutar hrvatske gramatičarske tradicije te triju suvremenih lingvističkih pristupa (teorija valentnosti i ovisnosna gramatika, kognitivna i generativna gramatika). Istraživanje dopuna i dodataka temelji se na trima različitim teorijama, što ima metodološko opravdanje u teorijskim pitanjima koje postavlja ovaj projekt: kojim se kriterijima mogu definirati i izdvojiti dopune i dodatci u hrvatskom, koliko je uvriježeno razlikovanje dopuna i dodataka gramatički održivo te može li ta razlika biti teorijski neovisno definirana. Praktična strana projekta obuhvaća stvaranje mrežnoga repozitorija hrvatskih rečenica s glagolima uz koje se nalaze rečenični dijelovi dvojbene sintaktičke. Analiza rečenica u repozitoriju služit će učiteljima i profesorima hrvatskoga jezika kao pomoćno sredstvo pri poučavanju te studentima svih jezičnih smjerova. Konačno, repozitorij će biti izvor podataka o hrvatskom domaćim i inozemnim lingvistima, bit će lako poveziv s ostalim jezičnim resursima. Kad se teorijski precizno opiše razlika dopuna i dodatka te se takvo sintaktičko razlikovanje oprimjeri u repozitoriju, ova bi se razina opisa mogla implementirati u sintaktičke oznake na korpusima hrvatskoga jezika. Na projektu će sudjelovati istaknuti lingvisti i četvero mladih istraživača, kojima će rad na projektu pružiti priliku za usavršavanje i istraživanje. Usmjeravajući pozornost na nedovoljno proučene pojavnosti u hrvatskom, istraživanja na ovom projektu doprinijet će još boljem razumijevanju strukture hrvatskoga jezika te razumijevanju jezika uopće. Istraživanje ima važnost i u svjetlu trenutačne reforme hrvatskoga obrazovnog sustava u primjeni teorijskih znanja u jezičnoj analizi i u stvaranju učinkovitijih metoda podučavanja hrvatskoga s pomoću modernih alata.]]></summary_hr><summary_en><![CDATA[The main objective is to precisely define the criteria for distinguishing arguments and adjuncts in Croatian. From the theoretical point of view the project will encompass an analysis of the treatment of arguments and adjuncts in traditional Croatian grammars, and in three contemporary linguistic theories (Valence Theory and Dependency Grammar, Cognitive and Generative Grammar). The research of arguments and adjuncts based on three different linguistic theories is methodologically justified by theoretical demands this project seeks to answer: (1) which criteria and tests are suitable to define and extract arguments and adjuncts in Croatian, (2) is the established distinction between arguments and adjuncts grammatically tenable (3) could the distinction between arguments and adjuncts be theory-independently defined. The applied part of the project consists in building an online repository containing examples of sentences with ambiguous syntactic phrases, and their exhaustive analyses. Teachers and students of Croatian will be able to use it as an assistant tool in teaching. The repository will be a source of information about the structure of Croatian for both Croatian and foreign linguists, and it can be linked to other resources at the Institute. When the difference between arguments and adjuncts is defined and applied, that level of description could be implemented in syntactic annotations of all Croatian corpora. The project will gather prominent linguists and four young researchers, who will get the opportunity for training and research.By focusing on the understudied features of Croatian grammar, the project research will contribute to better description of the overall structure of Croatian. In the light of the current educational reform in Croatia this research carries important implications, not only for the application of theoretical knowledge in language analysis, but also for creating more efficient teaching methods of Croatian through user-oriented tools.]]></summary_en></project><project>
<id>9073</id><title_hr><![CDATA[Epidemiologija Parkinsonove bolesti u Hrvatskoj i utjecaj genetskih čimbenika i mikrobiote na progresiju bolesti i ishod liječenja]]></title_hr><title_en><![CDATA[The epidemiology of Parkinson’s disease in Croatia and the influence of genetic factors and microbiota on the progression and treatment outcomes of the disease]]></title_en><user_id>17378</user_id><user_firstLast_name>Vladimira Vuletic</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-7276</code><acronim><![CDATA[GiOPARK]]></acronim><duration>01.02.2020 - 31.01.2024</duration><status>Završio</status><financ_value>198.026,54 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Kliničke medicinske znanosti, Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Clinical sciences, Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Medicine]]></institution_en><team_members_id>27280, 27282, 2684, 24156, 20223, 7505, 19607, 27215, 27281, 27189, 27223, 27123, 6457, 13812, 25495, 862790, 863806, 862799, </team_members_id><team_members_names><![CDATA[Borut Peterlin, Nir Giladi, Fran Borovečki, Nenad Bogdanovic, Smiljana Ristić, Nada Starčević Čizmarević, Valentino Rački, Slavica Kovačić, Merica Aralica, Eliša Papić, Mira Bučuk, Saša  Ostojić, Lidija Bilić-Zulle, Miljenko Kapović, David Bonifačić, Anja Babić, Marina Legac Škifić, Kristian Stojšić, ]]></team_members_names><keywords_hr><![CDATA[Parkinsonova bolest, mikrobiota, genetska epidemiologija, okolišni čimbenici, neurodegenerativne bolesti, ekstrapiramidne bolesti]]></keywords_hr><keywords_en><![CDATA[Parkinsons disease, microbiota, genetic epidemiology, enviromental factors, neurodegenerative diseases, extrapiramidal diseases]]></keywords_en><summary_hr><![CDATA[Parkinsonova bolest je druga najčešća neurodegenerativna bolest, koja zahvaća od 2-3% opće populacije iznad 65te godine života. Broj oboljelih je u stalnom porastu zbog općeg starenja populacije te time značajno utječe na društvo. Točan uzrok je nepoznat, no smatra se da do bolesti dolazi zbog složenih interakcija između genetskih, okolišnih i intrinzičnih čimbenika te da je potrebno bolest proučavati cjelovitim pristupom. Postoji nedostatak istraživanja koji se bave najranijom fazom bolesti prije početka liječenja, te nedostatak genetskih epidemioloških istraživanja za Parkinsonovu bolest u našoj državi. Planiramo provesti interdisciplinarni, kolaborativni projekt koji uključuje dva istraživanja, a u kojem će sudjelovati Medicinski fakultet Sveučilišta u Rijeci, Klinički bolnički centri Rijeka i Zagreb, Univerzitetni klinički centar Ljubljana te Karolinska Institutet u Švedskoj. Glavni cilj epidemiološko genetičkog istraživanja su ispitati koje su mutacije gena najčešće u hrvatskoj populaciji bolesnika s familijarnim oblikom Parkinsonove bolesti. Kod prospektivne kliničke studije je cilj ispitati koji je utjecaj genetskih čimbenika i mikrobiote na progresiju bolesti i ishod liječenja kod Parkinsonove bolesti. U tu svrhu će se svim ispitanicima napraviti sekvenciranje cijelog egzoma, dok će se u prospektivnoj kliničkoj studiji učiniti i analiza sastava i funkcije mikrobiote te zbog markeri progresije bolesti kako bi se rasvijetlili međuodnosi tih čimbenika na progresiju i prognozu bolesti. Također, u sklopu istraživanju će biti uspostavljena nova metoda analize patološke konformacije proteina u suradnji s Karolinska Institutetom. Očekujemo da će projekt utjecati na znanstveno područje, struku i društvo te će biti završetkom projekta biti jasniji međusobni utjecaj genetskih i okolišnih čimbenika u nastanku i progresiji Parkinsonove bolesti, kao i ishodu liječenja, što može dovesti i do razvijanja nove ciljane terapije usmjerene na genetske ili okolišne čimbenike.]]></summary_hr><summary_en><![CDATA[Parkinson&#39;s disease is the second most common neurodegenerative disease, which affects around 2-3% of the general population above the age of 65. The number of people affected by it is constantly increasing due to an increased number of elderlies. Parkinson’s disease most likely occurs due to a complex interaction between genetic, environmental and intrinsic factors that make a comprehensive approach to the disease a necessity. There is a lack of research in both the earliest phase of the disease before treatment starts and in genetic epidemiological research for Parkinson’s disease in our country. We plan to implement an interdisciplinary project involving two studies, which will be done at the Faculty of Medicine of the University of Rijeka, the Clinical Hospital Centers Rijeka and Zagreb, the University Hospital Centre Ljubljana and the Karolinska Institutet. The aim of epidemiological genetic research is to investigate which genetic mutations are prevalent in the Croatian population of patients with familial Parkinson&#39;s disease. In the prospective clinical study, the aim is to investigate the influence of genetic factors and microbiota on the progression and the outcome of treatment. Whole exome sequencing will be performed for all subjects, while the analysis of the composition and function of the microbiota, disease progression markers will be performed to clarify the effect of these factors on the progression and prognosis of the disease. Also, a new method of analyzing pathological protein conformation will be established in co-operation with the Karolinska Institute in Sweden. We expect that the project will impact the scientific field, profession and society and that completion of the project will provide a clearer influence on the genetic and environmental factors in the emergence and progression of the disease as well as the outcome of treatment, which can lead to the development of new targeted therapy directed at genetic or environmental factors.]]></summary_en></project><project>
<id>9078</id><title_hr><![CDATA[Dizajn katalitički aktivnih peptida i peptidnih nanostruktura]]></title_hr><title_en><![CDATA[Design of short catalytic peptides and peptide assemblies ]]></title_en><user_id>24626</user_id><user_firstLast_name>Daniela Kalafatovic</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2019-04</proposal_call><code>UIP-2019-04-7999</code><acronim><![CDATA[DeShPet]]></acronim><duration>01.02.2020 - 30.06.2025</duration><status>Završio</status><financ_value>265.392,53 eur</financ_value><scie_area_hr>Prirodne znanosti, Tehničke znanosti, Biomedicina i zdravstvo, </scie_area_hr><scie_area_en>Natural sciences, Technological sciences, Biomedicine and health sciences, </scie_area_en><scie_field_hr>Interdisciplinarne prirodne znanosti, Kemija, Biologija, Računarstvo, Biotehnologija u biomedicini, </scie_field_hr><scie_field_en>Interdisciplinary natural sciences, Chemistry, Biology, Computer sciences, Biotechnology in Biomedicine, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Tehnički fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Engineering]]></institution_en><team_members_id>2658, 26358, 6094, 855605, 856300, 865282, 861667, 861663, 869795, </team_members_id><team_members_names><![CDATA[Goran Mauša, Ana Sofia Pina, Marko Perčić, Patrizia Janković, Erik Otović, Marko Babić, Toni Todorovski, Marko Njirjak, Ena Dražić, ]]></team_members_names><keywords_hr><![CDATA[Peptidi, samoorganizacija, kataliza, strojno učenje, modeli predviđanja, AFM, meki materijali]]></keywords_hr><keywords_en><![CDATA[Peptides, self-assembly, catalysis, machine learning, prediction models, AFM, soft materials]]></keywords_en><summary_hr><![CDATA[Područje umjetnih enzima u posljednje je vrijeme privuklo veliku pozornost istraživačke zajednice te su predloženi razni pristupi oponašanja bioloških katalizatora. Jedan od pristupa je stvaranje minimalističkih katalizatora na osnovi peptida i njihovih samoorganizirajućih nanostruktura. Peptidi su od velikog interesa u biomedicini zbog svoje inherentne bio-kompatibilnosti i biorazgradivosti, niske toksičnosti metabolita i zbog činjenice da su gradivni blokovi života. Poznato je da se kratki peptidi mogu samostalno organizirati u nano-strukture s različitim fizičkim i strukturnim karakteristikama, što često rezultira novim svojstvima i funkcijama koje nisu vidljive u njihovim monomerima, tj. sekvencama. Jedna takva funkcija je katalitička aktivnost. S druge strane, malo je poznato o principima koji reguliraju katalitičku aktivnost kratkih peptida, ali iz prethodnih istraživanja znamo da su i aminokiseline i njihov redoslijed unutar sekvence važni. U ovom projektu namjeravamo povezati strojno učenje i eksperimentalnu validaciju kako bi provedbu budućih eksperimenata učinili ciljanom, a time učinkovitijom i ekonomičnijom. U tu svrhu nastojati ćemo otkriti obrasce u postojećim podacima te ubrzati otkrivanje novih katalitičkih peptida kroz relativno mali broj eksperimenata. Sveobuhvatni cilj ovog projekta je odrediti možemo li uporabom strojnog učenja učinkovito predviđati katalitičku aktivnost kratkih peptida te otkriti ključne značajke koje upravljaju ovim procesom. U konačnici, želimo razumjeti kako određena peptidna sekvenca postiže katalitičku aktivnost te na koji se način željena funkcija može ostvarit kroz evoluciju sekvence u složenije (samoorganizirajuće i/ili tandemske) sustave. Upotrebom metodologije predložene ovim projektom želimo dati temelje za novu generaciju dizajna peptida, čija će se strategija moći proširiti na druge domene istraživanja kemijskog prostora te na nova otkrića.]]></summary_hr><summary_en><![CDATA[Artificial enzymes have attracted tremendous interest in recent years and several approaches to mimic biological catalysts have been proposed. One approach is to create minimalistic catalysts based on peptides and their assemblies. Peptides are increasingly investigated in biomedical applications due to their inherent biocompatibility, biodegradability, low toxicity of metabolites and because they are building blocks of life. Short peptides can self-assemble into nanostructures, which often results in new emerging functions, not observable with their constituting monomers. One such function is catalytic activity. Little is known about the principles that govern the catalytic activity of short peptides at the sequence level. From previous studies it is evident that the residues that make up the sequence and the order in which they appear are important. In this project, we want to combine machine learning with experimental validation to develop a more efficient and economical approach compared to the unguided experimental evaluation. We aim to discover patterns in existing data and accelerate the discovery of new catalytic peptides within a relatively small number of experiments. The overall objective is to determine whether we could use machine learning to efficiently predict the catalytic activity of short peptides and understand what are the key features that govern this process. We aim to reveal how are peptide sequences responsible for catalysis with the scope of evolving them to more complex systems, through self-assembly or tandem peptide repeats, to reach function. In our approach we aim to encompass the entire spectrum from fundamental understanding of peptide sequences and their ability to catalyze reactions to eventual societal benefit of discovering minimalistic versions of enzymes able to be used in every day life. The successful outcome of this project will result in a strategy able to explore broad sequence and structural spaces for future discoveries.]]></summary_en></project><project>
<id>9082</id><title_hr><![CDATA[Prediktivno upravljanje dinamikom vozila]]></title_hr><title_en><![CDATA[Predictive vehicle dynamics control]]></title_en><user_id>6481</user_id><user_firstLast_name>Šandor Ileš</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2019-04</proposal_call><code>UIP-2019-04-6487</code><acronim><![CDATA[PVDC]]></acronim><duration>01.03.2020 - 28.02.2025</duration><status>Završio</status><financ_value>186.359,92 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, Temeljne tehničke znanosti, </scie_field_hr><scie_field_en>Electrical engineering, Basic engineering sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>27081, 865417, </team_members_id><team_members_names><![CDATA[Marko Švec, Josip Kir Hromatko, ]]></team_members_names><keywords_hr><![CDATA[Upravljanje dinamikom vozila, vektoriranje momenta, modelsko prediktivno upravljanje, adaptivni tempomat, bespovratno podupravljanje]]></keywords_hr><keywords_en><![CDATA[Vehicle dynamics control, torque vectoring, model predictive control, adaptive cruise control, terminal understeer]]></keywords_en><summary_hr><![CDATA[Napredni sustavi upravljanja dinamikom vozila postali su standard u suvremenim automobilima, ne samo kako bi se povećala udobnost putnika već i zaštitili putnici i drugi sudionici u prometu.U zadnjih nekoliko godina istraživanje na području modelskog prediktivnog upravljanja dinamikom vozila je posebno aktivno. Takav način upravljanja koristi model sustava kako bi se predvidjelo buduće vladanje sustava na konačnom predikcijskom horizontu.  U svakom koraku rješava se optimizacijski problem kako bi se postiglo optimalno vladanje sustava na predikcijskom horizontu. Rezultat optimizacije je optimalna upravljačka sekvenca, čiji se prvi element primjenjuje na sustav i cijeli se postupak ponavlja. Najveća prednost ovog načina upravljanja je što se na sustavan način uzima u obzir dinamički model sustava, kao i njegova fizikalna ograničenja.Iako modelsko prediktivno upravljanje pokazuje obećavajuće rezultate u upravljanju uzdužnom i bočnom dinamikom vozila, još nema komercijalno dostupnih vozila koje ga koriste. Većina radova u literaturi koristi linearni vremenski promjenjivi model vozila i nemaju garancija za postojanje rješenja optimizacijskog problema u svakom koraku kao ni garancije da će optimizacijski problem biti riješen u zadanom vremenu.Projektom PVDC, planiraju se istražiti algoritmi modelskog prediktivnog upravljanja za uzdužnu i bočnu dinamiku zasnovani na linearnom vremenski promjenjivom modelu, ali i nelinearnom modelu vozila sa garancijama stabilnosti i postojanja rješenja prilikom uzastopnog rješavanja optimizacijskog problema. Ispitivanje algoritma upravljanja je predviđeno u simulacijskom okruženju, ali i eksperimentalno na laboratorijskom postavu izrađenom u sklopu projekta koji se sastoji od pokretne trake odgovarajućih dimenzija i skaliranog modela automobila koji omogućava neovisno upravljanje  momentom na pojedinim kotačima. Eksperimentalni postav omogućit će ispitivanje jesu li razvijeni algoritmi upravljanja izvedivi u stvarnom vremenu.]]></summary_hr><summary_en><![CDATA[Advanced vehicle dynamics control systems have become standard in modern automobiles, not only to increase comfort but also to increase the safety of passengers and other traffic participants.Recently, research in the field of Model Predictive Control(MPC) of vehicle dynamics is particularly active. MPC is a control approach in which a model of the system is used to predict its behavior on a finite prediction horizon. At every sampling instant, an optimization problem is solved to ensure optimal system behavior along the horizon. The first element in the obtained optimal control input sequence is applied to the plant and the whole procedure is repeated. Its greatest advantage is that it systematically takes into account the dynamical model of the system, as well as its constraints.Even though MPC shows promising results when controlling both longitudinal and lateral vehicle dynamics, there are still no commercially available vehicles that use MPC. Most of the papers in the literature use a linear time-varying model of the vehicle and do not provide the guarantees of the recursive feasibility as well as the guarantees that the optimization problem will be solved within the sampling time. With the PVDC project, it is planned to investigate MPC algorithms for both longitudinal and lateral vehicle dynamics based on both linear time-varying model and a nonlinear model of the vehicle and to provide stability and recursive feasibility guarantees. The control algorithms will be tested in a simulation environment, but also experimentally on the laboratory setup created within the project, which consists of a treadmill of a suitable size for the testing maneuvers and a scaled car which allows independent torque control of its wheels. The driver will be able to control the vehicle using a steering wheel and pedals to gain insight into the behavior of the tested algorithm. The experimental setup will enable testing real-time feasibility of the developed control algorithms.]]></summary_en></project><project>
<id>9085</id><title_hr><![CDATA[Teme i aspekti hrvatske fotografije od 19. stoljeća do danas]]></title_hr><title_en><![CDATA[Themes and Aspects of Croatian Photography from the 19th Century until Today]]></title_en><user_id>3151</user_id><user_firstLast_name>Sandra Križić Roban</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-1772</code><acronim><![CDATA[Ekspozicija ]]></acronim><duration>01.02.2020 - 31.01.2024</duration><status>Završio</status><financ_value>53.553,12 eur</financ_value><scie_area_hr>Humanističke znanosti, Tehničke znanosti, Interdiciplinarne znanosti, Društvene znanosti, Prirodne znanosti, </scie_area_hr><scie_area_en>Humanities, Technological sciences, Interdisciplinary scientific area, Social sciences, Natural sciences, </scie_area_en><scie_field_hr>Interdisciplinarne humanističke znanosti, Arhitektura i urbanizam, Informacijske znanosti, Filozofija, Povijest umjetnosti, Znanost o umjetnosti, Etnologija i antropologija, Rodni studiji, Interdisciplinarne prirodne znanosti, Interdisciplinarne tehničke znanosti, Interdisciplinarne društvene znanosti, </scie_field_hr><scie_field_en>Interdisciplinary humanities, Architecture and Urban Environment, Information sciences, Philosophy, Art history, Arts, Ethnology and anthropology, Gender Studies, Interdisciplinary natural sciences, Interdisciplinary technological sciences, Interdisciplinary social sciences, </scie_field_en><institution_hr><![CDATA[Institut za povijest umjetnosti]]></institution_hr><institution_en><![CDATA[Institute of Art History, Zagreb]]></institution_en><team_members_id>25768, 3905, 292, 304, 1090, 23611, 26068, 4789, 858419, </team_members_id><team_members_names><![CDATA[Hrvoje Gržina, Ana Šverko, Stella Fatović-Ferenčić, Martin Kuhar, Leonida  Kovač, Ana Šeparović, Ante Orlović, Tihana Rubić, Lana Lovrenčić, ]]></team_members_names><keywords_hr><![CDATA[fotografija, teorija, povijest, kritička teorija, identitet, vrijeme, slikovni obrat, edukacijski obrat, etika reprezentacije]]></keywords_hr><keywords_en><![CDATA[photography, theory, history, critical theory, identity, time, pictorial turn, educational turn, representational ethics ]]></keywords_en><summary_hr><![CDATA[Unatoč vrlo ranoj pojavi svega desetljeće nakon njezina izuma, fotografija unutar relativno tradicionalne strukture hrvatske povijesti umjetnosti nikad nije stekla punopravnu poziciju u odnosu na druge umjetničke medije. U Hrvatskoj se dosad najčešće razmatrala u humanističkim znanostima i umjetničkom području, te je uglavnom korištena kao pomoćni tehnički alat pri drugim vrstama istraživanja. Njezina marginalizirana pozicija na nacionalnom planu prouzročila je pak posvemašnje zanemarivanje teorije i kritike fotografije, što je u velikom nerazmjeru sa situacijom u Europi i svijetu. Ako je ovaj problem evidentan na umjetničkom polju, on postaje još akutniji kada se govori o poziciji fotografije u drugim poljima, kao što su tehničke i prirodne znanosti. Naime, fotografija je “alat” nužan u čitavom nizu znanstvenih područja, a njezina sposobnost da “svjedoči” istinitost trenutka, kao i mogućnost da njezin vizualni sadržaj pojašnjava određene fenomene, civilizacijska otkrića i drugo, u nacionalnom kontekstu dosad nisu bili istraženi ni prezentirani javnosti. Suvremeno tumačenje fotografije zahtjeva umrežavanje i kombinaciju analitičkih i interpretativnih pristupa koji joj prilaze iz različitih kutova promatranja. Upravo u nedvojbenom nedostatku interdisciplinarnog i transdisciplinarnog istraživanja hrvatske fotografije na razini svjetskih istraživanja ovog medija nalazimo prostor i potrebu za provedbom ovog istraživačkog projekta, ključnog za hrvatsku povijest umjetnosti, a pritom usko povezanog uz druge humanističke, prirodne i tehničke discipline.]]></summary_hr><summary_en><![CDATA[Despite its very early appearance only a decade after its invention, within the relatively traditional structure of Croatian art history, it never achieved equal status to other artistic media. In Croatia it has most frequently been considered within the humanities and arts, and mainly used as a technical tool to help with other kinds of research. Its marginalised position in the national context led to a total disregard of the theory and criticism of photography, greatly at odds with the situation in Europe and the world. If this problem is evident in the arts, it is still more acute in other fields, such as the technological and natural sciences. Photography is an essential “tool” in a whole range of scientific fields, and its ability to “bear witness” to the truth of a moment, as well as its visual content’s ability to elucidate certain phenomena, civilisational discoveries and others, has not yet been researched nor presented to the public in the national context. The contemporary understanding of photography requires entering into a network, and a combination of analytic and interpretative approaches that consider it from various perspectives. It is precisely in the unambiguous lack of interdisciplinary and transdisciplinary research of Croatian photography at the level of international studies of this medium that we find the space and the need for our project, a key one for Croatian art history, and therefore closely connected with other disciplines in the humanities, as well in the natural and technological sciences.]]></summary_en></project><project>
<id>9086</id><title_hr><![CDATA[In-silico potpomognut dizajn supstrata za hvatanje CO2 u katalitičkoj formaciji karbonata i karbamata]]></title_hr><title_en><![CDATA[In silico aided design of CO2 trapping substrates for catalyzed formation of carbonates and carbamates]]></title_en><user_id>23209</user_id><user_firstLast_name>Dean Marković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-8846</code><acronim><![CDATA[INDICATIOR]]></acronim><duration>01.02.2020 - 31.07.2024</duration><status>Završio</status><financ_value>199.057,67 eur</financ_value><scie_area_hr>Prirodne znanosti, Interdiciplinarne znanosti, </scie_area_hr><scie_area_en>Natural sciences, Interdisciplinary scientific area, </scie_area_en><scie_field_hr>Kemija, Interdisciplinarne prirodne znanosti, </scie_field_hr><scie_field_en>Chemistry, Interdisciplinary natural sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Fakultet biotehnologije i razvoja lijekova]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Biotechnology and Drug Development]]></institution_en><team_members_id>3948, 6961, 26730, 19203, 20047, 25643, 3261, 5594, 861746, 865949, 11156, 348, 26869, 865894, </team_members_id><team_members_names><![CDATA[Karlo Wittine, Maja Abram, Laclef Sylvain, Petra Grbčić, Gabriela Ambrožić, Dario Matulja, Mirela Sedić, Valerije Vrček, FIlip Vranješević, Gordan Janeš, Dusko Cakara, Leo Frkanec, Nikolina Vidović, Maria Kolympadi Markovic, ]]></team_members_names><keywords_hr><![CDATA[katalitičke ciklizacije, ugljični dioksid, karbonati, karbamati, in silico dizajn , mehanističke studije, biološke aktivnosti, komputacije]]></keywords_hr><keywords_en><![CDATA[catalitic cyclization reactions, carbon dioxide, carbonates, carbamates, in silico design, mechanistic studies, biological activities, computations]]></keywords_en><summary_hr><![CDATA[Dugoročni cilj podnositelja je usmjeriti svoje istraživačke napore prema in-silico utemeljenom racionalnom predviđanju ključnih kemijskih svojstava kao što su termodinamički i kinetički parametri kako bi se projektirali reaktanti i modulirala njihova reaktivnost s konačnom eksperimentalnom potvrdom računski postavljene hipoteze. Na toj liniji projekt se bavi korištenjem ugljičnog dioksida kao obnovljivog i jeftinog ugljičnog resursa u modernim metal kataliziranim ciklizacijama kako bi se učinkovito i jednostavno napravili karbonati i karbamati. Ove reakcije će upotrijebiti nezasićene alkohole i amine kao partnere za spajanje s ugljičnim dioksidom, da bi se formirali ciklički karbonati, odnosno karbamati. Glavna poteškoća za razvoj takvih novih procesa je relativno velika stabilnost CO2 ((DHf (CO2) ? -94 kcalmol-1), a time i inertnost koju treba prevladati. Za razliku od objavljenih postupaka koji uglavnom koriste jednostavne visoko energetske reaktante za hvatanje CO2 kako bi dobili potrebnu endergoničnost reakcije, plan ovog prijedloga je razviti novi racionalni, in silico potpomognut pristup kako bi se prilagodila reaktivnost supstrata za hvatanje CO2. U ovom slučaju potrebna endergoničnost reakcije dolazi od stabilizacije produkata kroz stvaranje dodatnih C-C veza. Za brzu optimizaciju reakcijskih uvjeta koristit će se trodimenzionalne kombinatorne metode. Ova metodologija će se primijeniti za sintezu alifatskih i aromatskih karbonata i karbamata. Budući da mnogi organski karbamati i karbonati imaju jaka biološka djelovanja, biblioteka sintetiziranih spojeva testirat će se in vitro za njihove antitumorske i antibiotske aktivnosti. Također će se istražiti mehanizam opisanih transformacija. Kako bi se prikupili mehanistički podaci i kako bi se u potpunosti razjasnili operativni mehanizmi uključeni u ove transformacije, eksperimentalni rezultati bit će dopunjeni računalnim studijama.]]></summary_hr><summary_en><![CDATA[The long-term goal of applicant is to direct his research efforts towards the in silico based rational prediction of the key chemical properties such as thermodynamic and kinetic parameters in order to design reactants and modulate their reactivities with final experimental confirmation of computationally imposed hypothesis. On this line the project deals with the employment of carbon dioxide as a renewable and inexpensive carbon resource in modern metal-catalyzed cyclization reactions to form carbonates and carbamates in efficient and simple manner. These reactions will employ unsaturated alcohols and amines with carbon dioxide as coupling partners in order to form cyclic carbonates and carbamates, respectively. The main difficulty for the development of such new processes is relatively large stability of CO2 (?Hf(CO2)? -94 kcalmol-1) and thus, inertness that should be overcome. In contrast to literature reported procedures that mostly use simple highly energetic reactants to trap CO2 in order to gain necessary endergonicity of the reaction, the plan of this proposal is to develop new rational in silico aided approach in order to adjust reactivity of substrate for CO2 trapping. The necessary endergonicity of the reaction would, come from the product stabilization through additional bonds formation. Three-dimensional combinatorial methods will be employed for the fast optimization of the reaction conditions. This methodology will be applied for the synthesis of aliphatic and aromatic carbonates and carbamates. As many of organic carbamates and carbonates have potent biological activities a library of synthetized compounds will be tested in vitro for their anticancer and antibiotic activities. The mechanism of the described transformations will be also studied. In order to collect mechanistic data and to fully elucidate the operative mechanism involved in these transformations, experimental results will be supplemented with computation studies.]]></summary_en></project><project>
<id>9088</id><title_hr><![CDATA[Pametna platforma za daljinska istraživanja u okolišu i industriji primjenom milimetarskih valova]]></title_hr><title_en><![CDATA[Smart platform for millimeter-wave environmental and industrial sensing ]]></title_en><user_id>6893</user_id><user_firstLast_name>Marko Bosiljevac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-1064</code><acronim><![CDATA[MMSENSE]]></acronim><duration>15.01.2020 - 30.04.2024</duration><status>Završio</status><financ_value>113.222,38 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, Interdisciplinarne tehničke znanosti, </scie_field_hr><scie_field_en>Electrical engineering, Interdisciplinary technological sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>26560, 26522, 6886, 856246, 864956, 7148, 864988, 19032, </team_members_id><team_members_names><![CDATA[Sonja Grgić, Gordan Šišul, Dario Bojanjac, Filip Turčinović, Ivana Žeger, Dubravko Babic, Jakov Tutavac, Marko Šprem, ]]></team_members_names><keywords_hr><![CDATA[sustavi za daljinska istraživanja, milimetarski elektromagnetski valovi, nadzor okoliša, klasifikacija objekata, primijenjeno strojno učenje]]></keywords_hr><keywords_en><![CDATA[remote sensing systems, millimeter electromagnetic waves, environment sensing, object classification, applied machine learning]]></keywords_en><summary_hr><![CDATA[Daljinska istraživanja primijenjena u okolišu i industriji temeljena na multispektralnom ili radarskom snimanju danas imaju važnu ulogu u osiguravanju održivosti i zaštiti prirodnih resursa, uštedi vremena i energije u industriji i poljoprivredi te u mnogim drugim primjenama. Postoje brojni primjeri takvih sustava koji pružaju informacije poput kvalitete proizvoda proizvođačima, parametara rasta usjeva poljoprivrednicima ili detalje strukturalnog integriteta građevinskim inženjerima. Zahvaljujući napretku u razvoju tehnologije u području elektromagnetskih milimetarskih valova (mm-valova), u brzoj obradi signala i primjeni umjetne inteligencije, primjena daljinskih istraživanja kratkog dometa koja koriste mm-valove ima snažan rast pri čemu tržište diktira nove primjene sa sve većom razinom autonomije sustava.Cilj ovog projekta je istražiti i realizirati metodologije, algoritme i sklopovske koncepte koji će zadovoljiti zahtjeve novih primjena u smislu poboljšane autonomije, pristupačne cijene, energetske učinkovitosti i unaprijeđenja komunikacijskih mogućnosti. Specifični ciljevi koji će se postići su; (i) učinkovita klasifikacija objekata primjenom nadziranog strojnog učenja na temelju informacija o radarskom raspršenju mm-valova, (ii) poboljšani algoritmi obrade i kompresije signala u radarima za daljinska istraživanja koji koriste mm-valove, (iii) razvoj antenskog niza s pametnom kontrolom skeniranja zrake, i (iv) optimizacija komunikacijskog protokola za prijenos velikih količina podataka dobivenih daljinskim istraživanjem. Konačni cilj je demonstrirati razvijene tehnike na pametnoj platformi za daljinska istraživanja zasnovanoj na mm-valovima koja bi se mogla koristiti u raznim ekološkim ili industrijskim područjima i lako integrirati s drugim senzorima u mrežama Interneta stvari. Osim toga, ovo će istraživanje značajno unaprijediti razinu stručnosti naše grupe, a posebno mladih istraživača uključenih kroz diplomske i doktorske studije.]]></summary_hr><summary_en><![CDATA[Remote environmental and industrial sensing based on multi-spectral or radar imaging today plays an important role in ensuring sustainability and protection of natural resources, in saving time and energy in industry and agriculture, and in many other applications. Numerous examples of such systems exist which provide information like product quality to manufacturers, crops growth parameters to farmers or structural integrity details to civil engineers. With recent developments in electromagnetic millimeter-wave (mm-wave) technology, high-speed signal processing and artificial intelligence implementation, short range mm-wave remote sensing is experiencing strong growth with the market dictating new applications with increasingly higher levels of system autonomy. The objective of this project is to investigate and realize methodologies, algorithms and hardware concepts that will meet the demands of these new applications in terms of improved autonomy, reasonable cost, energy efficiency and improved communication possibilities. The specific goals that will be achieved are; (i) efficient supervised machine learning classification of objects based on mm-wave radar scattering information, (ii) improved signal processing and compressing algorithms for mm-wave remote sensing radars, (iii) development of antenna array with smart control of beam scanning, and (iv) optimization of communication protocol for transmission of large quantities of data obtained by remote sensing. The final goal is to demonstrate developed principles on a smart mm-wave remote sensing platform that could be used in various environmental or industrial fields and easily integrated with other sensors in Internet-of-Things networks. Additionally, this research will significantly advance the level of expertise of our group and in particular of the young researchers involved through Master and PhD studies.]]></summary_en></project><project>
<id>9095</id><title_hr><![CDATA[Istraživanje puteva energetske tranzicije - meduovisnost &#39;&#39;power-to-X&#39;&#39; tehnologija, tehnologija odgovora potrošnje i povezivanja tržišta energijom]]></title_hr><title_en><![CDATA[Investigating energy transition pathways -  interrelation between power-to-X, demand response and market coupling]]></title_en><user_id>13012</user_id><user_firstLast_name>Neven Duić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-9482</code><acronim><![CDATA[INTERENERGY]]></acronim><duration>01.12.2019 - 30.11.2023</duration><status>Završio</status><financ_value>106.709,14 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, </scie_field_hr><scie_field_en>Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>27136, 27143, 27141, 27140, 20485, 862777, 865227, 25095, 867120, </team_members_id><team_members_names><![CDATA[Antun Pfeifer, Ingo Stadler, Iva Ridjan  Skov, Fei Wang, Henrik Lund, Felipe Feijoo Feijoo, Luka Herc, Hrvoje Dorotić, Stanislav Boldyryev, ]]></team_members_names><keywords_hr><![CDATA[Energetska tranzicija, obnovljivi izvori energije, tehnologije pretvorbe elektricne energije, odgovor potrošnje, energetska tržišta]]></keywords_hr><keywords_en><![CDATA[Energy transition, renewable energy sources, power-to-X technologies, demand response, energy markets]]></keywords_en><summary_hr><![CDATA[Energetski sustavi u tranziciji od centralizirane proizvodnje temeljene na fosilnim gorivima s visokim emisijama stakleničkih plinova prema niskougljučnim sustavima temeljenim na promjenjivim i distribuiranim obnovljivim izvorima energije, prolaze kroz različite faze. U prvoj fazi, povišenje integracije promjenjivih obnovljivih izvora energije može se izvesti, u većini energetskih sustava, bez primjene dodatnih tehnologija za skladištenje i pretvorbu energije. U kasnijim fazama, pri visokom udjelu varijabilnih OIE u sustavu, sinergije s drugim sustavima  potrebne su za integraciju najpovoljnije i održive energije. Ovaj projekt bavi se međupovezanošću različitih &#39;&#39;power-to-X&#39;&#39; tehnologija i tržišnog povezivanja u energetskoj tranziciji. U ovom kontekstu, &#39;&#39;power-to-X&#39;&#39; može značiti tehnologiju pohrane jeftine električne energije u transformacijom u toplinsku energiju, korištenjem za proizvodnju sintetskih elektrogoriva ili sinergijom s elektrificiranim transportnim sustavom u &#39;&#39;vehicle-to-grid&#39;&#39; konceptu, kao i drugim tehnologijama koje koriste energiju iz promjenjivih OIE, koja inače ne bi mogla biti iskorištena, da bi dekarbonizirali druge sektore. Štoviše, uloga ovih tehnologija se izučava u kontekstu povezivanja tržišta, koje je već odmaklo u Europskoj uniji. ]]></summary_hr><summary_en><![CDATA[Energy systems in the transition from fossil-based and centralized production, with high GHG emissions, to low-carbon systems based on variable and distributed renewable energy, pass through different phases of transformation. In the first phases, the rise of integration of variable renewable energy sources (RES) can be performed in most energy system configurations without the implementation of additional storage and conversion technologies. In later stages, with a high share of variable RES in the mix, synergies with other systems are needed to integrate the cheapest and sustainable energy. This project deals with interrelation between different power-to-x technologies and market coupling in the energy transition. In this context, power-to-X can mean power-to-heat in district heating systems, the power to electro-fuels or synergies with electrified transport sector in vehicle-to-grid concept, as well as other technologies, which use variable renewable energy, which would need to be curtailed otherwise, for decarbonization of other sectors. Moreover, the role of these technologies is investigated from the context of market coupling, which is already underway in the European Union. ]]></summary_en></project><project>
<id>9101</id><title_hr><![CDATA[Biotehnološka primjena ugradnje heterolognih proteina u stanične stijenke kvasaca]]></title_hr><title_en><![CDATA[Biotechnological application of surface engineering by incorporation of heterologous proteins in the yeast cell wall ]]></title_en><user_id>3258</user_id><user_firstLast_name>Renata Teparić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-2891</code><acronim><![CDATA[PRODIS]]></acronim><duration>10.12.2019 - 09.06.2024</duration><status>Završio</status><financ_value>159.420,77 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Biotehnologija, </scie_field_hr><scie_field_en>Biotechnology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Food Technology and Biotechnology]]></institution_en><team_members_id>4377, 25073, 4314, 4764, 25089, 27364, 13195, 4031, 4450, 862772, 865228, </team_members_id><team_members_names><![CDATA[Igor Stuparevic, Ana Novačić, Anita Slavica, Damir Iveković, Mateja Lozančić, Branko Kozulić, Ksenija Lopandić, Antonija Grbavac, Bojan Žunar, Egon Rešetar, Tea Martinić Cezar, ]]></team_members_names><keywords_hr><![CDATA[molekularna biotehnologija, kvasac, S. cerevisiae, P. pastoris, stanična stijenka, izlaganje proteina, genetička imobilizacija, ksiloza reduktaza]]></keywords_hr><keywords_en><![CDATA[molecular biotechnology, yeast, S. cerevisiae, P. Pastoris,  cell wall, surface display, genetic immobilization, xylose reductase]]></keywords_en><summary_hr><![CDATA[Spoznaje vezane uz molekularne mehanizme biosinteze staničnih stijenki kvasaca omogućile su razumijevanje osnovnih bioloških principa koje stanice koriste za izgradnju vanjskog omotača s odgovarajućim biofizičkim i biokemijskim svojstvima i dizajniranje površine stanice u skladu s pojedinim biotehnološkim potrebama. Stanična stijenka sastoji se od unutrašnjeg kostura od ß-1,3- i ß-1,6-glukana i manoproteina čiji mananski lanci formiraju vanjski sloj stijenke. Dio proteina veže se na glukan nekovalentnim vezama, dok se drugi dio veže kovalentno, ili povezivanjem glikozilfosfatidilinozitolnog sidra i ß-1,6-glukana ili karakteristične Pir-sekvence s ß-1,3-glukanom. Dodavanje odgovarajućih signalnih sekvencija heterolognim proteinima eksprimiranima u kvascu omogućilo je njihovo izlaganje na površini stanice. Tako su stanice poslužile za biosintezu i imobilizaciju tih proteina, a postupak je omogućio kreiranje novih biološki aktivnih materijala. U svim do sada opisanim slučajevima količina aktivnosti eksprimirana na površini stanica bila je razmjerno mala pa je za primjenu ove tehnologije ključno povećati količinu heterolognih proteina izloženih na površini stanice. To će se u okviru ovog projekta pokušati modificiranjem različitih molekularnih procesa uključenih u izgradnju stijenke kao što su sekrecija, glikozilacija proteina, endocitoza, vezanje GPI sidra ili vezanje autohtonih proteina stijenke.U drugom dijelu, metoda izlaganja proteina primijenit će se na dva nova tehnološki važna proteina, metionil adenozin transferazu (MAT), ključnog enzima u proizvodnji S-adenozilmetionina i saharoza fosforilazu (SPaza) koja u reakciji sa saharozom katalizira sintezu glukozilglicerola. Oba proizvoda danas se dobivaju biotransformacijama pri čemu se supstrati moraju transportirati u stanicu kvasca što predstavlja limitirajući faktor u proizvodnji. Stoga bi relociranje reakcije izvan stanice moglo značajno olakšati proces biosinteze što će se istražiti u ovom projektu.]]></summary_hr><summary_en><![CDATA[Our knowledge on molecular mechanisms of yeast cell wall biosynthesis enabled comprehension of basic biological principles used to build the external envelope with adequate biophysical and biochemical properties and designing the cell surface according to specific biotechnological needs. Cell wall comprises inner moiety of ß-1,3- and ß-1,6-glucan, and mannoproteins whose mannan chains form the outer layer of the wall. A part of proteins are linked to glucan non-covalently, while some other are bound covalently, either through GPI-anchors and ß-1,6-glucan, or by linking a characteristic Pir-sequence to ß-1,3-glucan. Addition of corresponding signal sequences to heterologous proteins expressed in yeasts lead to their exposure at the cell surface. Thus, cells both synthesized and immobilized these proteins. As biologically active proteins can be exposed at the surface, the procedure enabled creation of new biologically active materials. So far the level of enzyme activity expressed at the cell surface was low and for the practical use of this methodology it would be important to increase the amount of heterologous protein in the wall. It will be attempted by modifying different molecular processes involved in wall formation like secretion, protein glycosylation,endocytosis,GPI-anchor addition, or binding of autochthonous cell wall proteins.In the second part, the surface display method would be applied to two new technologically important enzymes, methionine adenosine transferase (MAT), the key enzyme in the production of S-adenosyl methionine, and succrose phosphorylase that catalysis the formation of glucosyl glycerol in a reaction with succrose. Both products are presently produced by biotransformations in which substrates have to be transported into the yeast cells which presents the limiting production factor. Therefore, relocating the reaction to the external surface of the cell could facilitate the bioproduction which would be investigated in this project.]]></summary_en></project><project>
<id>9102</id><title_hr><![CDATA[Digitalna tehnologija u obitelji: obrasci ponašanja i učinci na razvoj djece]]></title_hr><title_en><![CDATA[Digital technology in the family: patterns of behaviour and effects on child development]]></title_en><user_id>6384</user_id><user_firstLast_name>Marina Merkaš</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2019-04</proposal_call><code>UIP-2019-04-7547</code><acronim><![CDATA[ D.E.C.I.D.E.]]></acronim><duration>01.01.2020 - 31.12.2024</duration><status>Završio</status><financ_value>185.221,32 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Psihologija, </scie_field_hr><scie_field_en>Psychology, </scie_field_en><institution_hr><![CDATA[Hrvatsko katoličko sveučilište, Zagreb]]></institution_hr><institution_en><![CDATA[Catholic University of Croatia]]></institution_en><team_members_id>26679, 2783, 26683, 855440, 865188, </team_members_id><team_members_names><![CDATA[Vanesa Varga, Marina Kotrla Topić, Katarina Perić, Ana Žulec, Matea Bodrožić Selak, ]]></team_members_names><keywords_hr><![CDATA[digitalna tehnologija, obitelj, roditelji, djeca, dobrobit, razvoj]]></keywords_hr><keywords_en><![CDATA[digital technology, family, parents, children, well-being, development]]></keywords_en><summary_hr><![CDATA[Digitalna tehnologija (DT) oblikuje život djece, roditelja i obitelji svakodnevno. Projekt D.E.C.I.D.E. ima za cilj ispitati: a) motivaciju, navike i okolnosti korištenja DT te ometanje tehnologijom (OT) u roditelja, djece i obitelji, b) povezanost korištenja DT te OT u djece, roditelja i obitelji s razvojem i dobrobiti djece i c) OT tijekom interakcija roditelj-dijete te učinke OT na ponašanje djece. Na temelju rezultata dosadašnjih istraživanja, teorijskih objašnjenja učinaka kontekstualnih čimbenika na razvoj djece, obiteljske medijske ekologije, bioekološkog modela ljudskog razvoja, modela različite osjetljivosti na učinke medija, teorija o recipročnim učincima medija te preporuka za buduća istraživanja, postavljen je model mogućih učinaka i procesa djelovanja DT na djecu u obiteljskom kontekstu. Kombinacijom kvalitativne i kvantitativne istraživačke metodologije kroz 4 studije (fokus grupe, longitudinalno istraživanje, dnevničku studiju i opažanje) s djecom od 0 do 13 godina i roditeljima, empirijski se žele provjeriti hipoteze o diferencijalnoj osjetljivosti djece, roditelja i obitelji na učinke DT te OT, kao i postojanje neizravnih procesa djelovanja DT i OT na djecu. Očekuje se potvrda različite osjetljivosti djece, roditelja i obitelji na DT i OT te neizravnih procesa djelovanja DT i OT na razini pojedinca, odnosa i sustava na razvoj i dobrobit djece. Po završetku projekta očekuje se uspostavljena istraživačka grupa, 7 pozitivno recenziranih i/ili prihvaćenih za objavljivanje znanstvenih radova, 15 izlaganja na konferencijama, izrađena 1 disertacija i 3 diplomska rada, održane 2 istraživačke radionice sa stručnjacima iz inozemstva i festival za djecu i obitelji. Projektom se želi stvoriti baza znanja o učincima DT na razvoj djece u obiteljskom kontekstu, koja bi onda poslužila svim akterima dječjeg razvoja za osmišljavanje različitih praktičnih programa utemeljenih na dokazima i usmjerenih umanjivanju negativnih, a poticanju pozitivnih učinaka DT na djecu.]]></summary_hr><summary_en><![CDATA[Digital technology (DT) shapes the lives of children, parents, and families daily. Project D.E.C.I.D.E. aims to examine: a) the motivation, habits, and circumstances of DT use and technology interference (TI) in parents, children, and families, b) the relations of DT use and TI in children, parents, and families with child development and well-being, and c) TI during parent-child interaction and TI effects on the behaviour of children. Based on the results of the previous research, theoretical explanations of the effects of contextual factors on child development, family media ecology, the bioecological model of human development, the differential susceptibility to media effects model, theories about reciprocal effects of media, and recommendations for future research, a model of the possible effects and processes of effects of DT and TI on children in a family context is developed. An empirical examination of proposed hypotheses about the differential sensitivity of children, parents, and families to the effects of DT and TI, and the indirect effects and processes of effects of DT and TI on children is planned using qualitative and quantitative research methodology via 4 studies with children aged 0 to 13 years and parents. The confirmation of different sensitivity of children, parents, and families to DT and TI and the indirect effects of DT and TI on child development and well-being are expected. Expected outcomes upon completion of the project: the established research group, 7 positively reviewed and/or published scientific papers, 15 held presentations, 1 dissertation and 3 graduate theses written, 2 research workshops and a festival for children and families held. The project aims to create a knowledge base on the effects of DT on child development in a family context, that would serve to all actors of child development for designing evidence-based practical programs aimed at reducing the negative and enhancing the positive effects of DT on children.]]></summary_en></project><project>
<id>9106</id><title_hr><![CDATA[Učinkoviti sustavi za obradu signala namijenjeni programski definiranom radiju]]></title_hr><title_en><![CDATA[Efficient Signal Processing Systems for Software Defined Radio]]></title_en><user_id>6945</user_id><user_firstLast_name>Mladen Vučić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-4189</code><acronim><![CDATA[EfficientSDR]]></acronim><duration>01.12.2019 - 30.04.2024</duration><status>Završio</status><financ_value>129.338,38 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>26211, 21316, 26017, 26212, 26018, 856294, 864963, 28913, </team_members_id><team_members_names><![CDATA[Goran Molnar, Maja Jurišić Bellotti, Aljosa Dudarin, Ante Miloš, Marko Matijaščić, Katarina Vodvarka, Tin Vlašić, Anita Gribl Gribl Koščević, ]]></team_members_names><keywords_hr><![CDATA[programski definiran radio, obrada signala u komunikacijama, dizajn digitalnih sustava, višetaktna obrada signala, prostorna filtracija, UWB radio]]></keywords_hr><keywords_en><![CDATA[software defined radio, signal processing for communications, digital system design, multirate signal processing, spatial filtering, UWB radio]]></keywords_en><summary_hr><![CDATA[Od bežičnih komunikacijskih sustava neprestano se traži sve veća brzina prijenosa. Stoga se ovi sustavi moraju stalno unaprjeđivati. To je posebno slučaj kod radijskih podsustava koji često predstavljaju usko grlo cijelih prijenosnih lanaca. Programski definiran radio prepoznat je kao ključna tehnologija za njihov razvoj. Slijedeći ovaj trend, predloženi projekt razmatra poboljšavanje postojećih te razvoj novih postupaka za dizajn sustava za obradu signala koji se koriste u programski definiranom radiju. Konkretno, projekt je usmjeren na učinkovite višetaktne sustave, konvencionalne i prostorne filtre, te na sustave koji optimalno iskorištavaju spektar u ultra-širokopojasnom radiju. Od svih ovih sustava traži se učinkovita obrada signala, ali i učinkovita implementacija. S ciljem da se poveća učinkovitost, u istraživanjima će biti korištena sinteza u vremenskoj i frekvencijskoj domeni, sažeto očitavanje, polinomno izoštravanje, optimizacija, te niz drugih analitičkih i numeričkih tehnika. Kao rezultat projekta očekuju se novi postupci za dizajn sustava za višetaktnu obradu signala te novi postupci za dizajn sustava s rijetkim koeficijentima kao što su selektivni filtri, derivatori, integratori te sustavi sa stalnim i promjenjivim kašnjenjem. Nadalje, očekuje se doprinos u dizajnu antenskih polja koja omogućavaju robusno oblikovanje dijagrama zračenja te osiguravaju približno nezavisno upravljanje širinom snopa, usmjerenošću, razinom bočnih latica te dinamičkim rasponom koeficijenata. Konačno, očekuju se novi postupci za sintezu energetski i spektralno učinkovitih pulsova za ultra-širokopojasne komunikacije. Dobiveni postupci bit će izravno primjenjivi u razvoju komunikacijskih sustava. Nadalje, uključenost doktorskih studenata osigurat će visok obrazovni učinak te prijenos znanja u industrijsko okruženje. Svi ovi faktori su važni obzirom da se posljednjih godina komunikacijski sektor u Hrvatskoj intenzivno razvija.]]></summary_hr><summary_en><![CDATA[There is a constant need for the increase of transfer rate in wireless communication systems. Therefore, these systems must be continuously improved. This is particularly true for radio subsystems, which are often bottlenecks of entire communication chains. Software defined radio has been recognized as crucial technology for their development. Following this trend, the proposed project considers the improvement of existing and the development of new methods for the design of signal processing systems for software defined radio. In particular, the project is focused on multirate systems, conventional and spatial filters, as well as on the systems for optimal utilization of spectrum in ultra-wideband radio. Efficient signal processing and efficient implementation are required of all these systems. To increase the efficiency, the research will utilize time- and frequency-domain synthesis, compressed sensing, polynomial sharpening, optimization and various other analytical and numerical techniques. As project results, new methods are expected for the design of systems for multirate signal processing and for the design of systems with sparse coefficients such as selective filters, differentiators, integrators and systems with constant and variable delay. Furthermore, a contribution is expected in the design of antenna arrays that enable robust beamforming and provide nearly independent control of beamwidth, directivity, sidelobe level, and dynamic range ratio. Finally, new methods will be developed for the synthesis of energy- and spectral-efficient pulses for ultra-wideband communications. The resulting methods will be directly applicable in the development of communication systems. Furthermore, the involvement of doctoral students will ensure a high educational impact and the transfer of knowledge to the industrial environment. All of these factors are important because in recent years the communication sector in Croatia develops intensively.]]></summary_en></project><project>
<id>9109</id><title_hr><![CDATA[Sociodemografske odrednice potrošnje energije u Hrvatskoj]]></title_hr><title_en><![CDATA[Sociodemographic determinants of energy consumption in Croatia]]></title_en><user_id>5037</user_id><user_firstLast_name>Marin Strmota</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2019-04</proposal_call><code>UIP-2019-04-3054</code><acronim><![CDATA[EnergoDem ]]></acronim><duration>01.01.2020 - 31.12.2024</duration><status>Prekinut</status><financ_value>72.823,28 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Demografija, Ekonomija, </scie_field_hr><scie_field_en>Demography, Economy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Ekonomski fakultet u Zagrebu]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Economics and Business]]></institution_en><team_members_id>22561, 3801, 27237, </team_members_id><team_members_names><![CDATA[Krešimir Ivanda, Tamara Slišković, Ivan Šušnjar, ]]></team_members_names><keywords_hr><![CDATA[Demografija, energija, održivost, resursi, potrošnja]]></keywords_hr><keywords_en><![CDATA[Demography, energy, sustainability, resources, consumption]]></keywords_en><summary_hr><![CDATA[Svrha projekta je osnovati samostalnu istraživačku jedinicu koja bi povezala znanstvene discipline demografije i makroekonomije, a čiji je cilj istražiti povezanost demografskih promjena i potrošnje energije u Hrvatskoj. Istraživanje korelacije razvoja energetskog sektora i ukupnog društveno-gospodarskog razvoja od posebne je važnosti u novije vrijeme tehnološkog napretka kojim se nastoje nadoknaditi negativni efekti nepovoljnih demografskih kretanja. Četiri istraživača komplementarnih istraživačkih interesa sačinjavalo bi istraživačku jedinicu. Svi istraživači su zaposleni na Ekonomskom fakultetu u Zagrebu, na Katedri za demografiju i Katedri za makroekonomiju i  gospodarski razvoj. Troje istraživača posjeduje doktorat ekonomskih znanosti, a jedan je u postupku stjecanja. S obzirom na nedovoljno istraženo područje i nerazvijenu istraživačku mrežu u projektu će se pristupiti povezivanju i statističkoj analizi postojećih izvora podataka o karakteristikama potrošnje energije i izradi nove anketne baze stanovnika-potrošača. Područje energetske politike, u vidu znanstvene i primijenjene dimenzije ekonomije i tehničkog područja, u recentnoj literaturi sve više ostvaruje interdisciplinarnu suradnju, a demografska dimenzija u posebnom je fokusu europskih zemalja. U europskim zemljama već postoji niz istraživanja koja problematiziraju demografsko starenje u okviru potrošnje energije. Hrvatsku, uz demografsko starenje karakterizira i iseljavanje pa su implikacije demografskih promjena i izraženije. Navedeno istraživanje uz znanstvenu svrhu približavanja suvremenim europskim trendovima u području društvenih znanosti, ima i vrijednu aplikativnu svrhu u okviru evaluacije nacionalnih i subnacionalnih energetskih politika. ]]></summary_hr><summary_en><![CDATA[The purpose of the project is to establish an independent research unit that would link the scientific disciplines of demography and macroeconomics to explore the correlation between demographic changes and energy consumption in Croatia. An exploration of the correlation between the development of the energy sector and the overall socio-economic development is of particular importance in the recent technological advances aimed at compensating for the negative effects of unfavorable demographic trends. Four researchers of complementary research interests would constitute a research unit. All researchers are employed at the Faculty of Economics in Zagreb, the Department of Demography and the Departments for Macroeconomics and Economic Development. Three researchers have a PhD in economics, and one is in the process of acquiring it. Due to the insufficiently explored area and the underdeveloped research network, the project will link and analyze existing data sources on energy consumption characteristics and create a new population-consumer survey database. The area of energy policy, in the form of scientific and applied dimensions of economics and technical area, is increasingly interdisciplinary in recent literature, and the demographic dimension is in a special focus of European countries. There are already a number of studies in European countries that problematize demographic aging in energy consumption. Croatia is characterized by demographic aging and emigration, so the implications of demographic changes are more pronounced. This research, along with the scientific purpose of approaching contemporary European trends in the field of social sciences, has a valuable applicative purpose in the evaluation of national and sub-national energy policies.]]></summary_en></project><project>
<id>9114</id><title_hr><![CDATA[Renesansa teorije uzorkovanja]]></title_hr><title_en><![CDATA[Renaissance of the Sampling Theory]]></title_en><user_id>6982</user_id><user_firstLast_name>Damir Seršić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-6703</code><acronim><![CDATA[SamplingRenaissance]]></acronim><duration>01.12.2019 - 31.05.2024</duration><status>Završio</status><financ_value>126.086,67 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, Računarstvo, </scie_field_hr><scie_field_en>Electrical engineering, Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>6991, 6592, 1087, 22636, 858332, 864963, 28913, 865244, </team_members_id><team_members_names><![CDATA[Davor Petrinović, Ana Sović Kržić, Azra Tafro, Ivan Ralašić, Tomislav Matulić, Tin Vlašić, Anita Gribl Gribl Koščević, Dorotea Potoč, ]]></team_members_names><keywords_hr><![CDATA[post-uzorkovanje, sažimajuće očitavanje, hibridni podatkovni modeli, hibridne metode obrade, svjetlosno polje, 3D rekonstrukcija, PET]]></keywords_hr><keywords_en><![CDATA[post-sampling, compressive sensing, hybrid data models, hybrid processing methods, light field, 3D reconstruction, PET]]></keywords_en><summary_hr><![CDATA[Uzorkovanje i rekonstrukcija signala sačinjavaju središnji dio digitalne obrade signala (DSP). Teorem uzorkovanja predstavlja vezu između kontinuiranog i diskretnog svijeta u modernim elektroničkim uređajima, pametnim telefonima, kamerama te medicinskoj opremi. Sažimajuće očitavanje (CS) tehnika je koja se oslanja na konačnu frekvenciju inovacije kako bi se smanjio broj mjerenja potrebnih za statistički pouzdanu rekonstrukciju.  Brz napredak u ovom području istraživanja predstavlja renesansu teorije uzorkovanja, prvenstveno zbog svog značaja za znanstvenu zajednicu koja se bavi digitalnom obradom signala.Naše istraživanje doprinosi ovom izazovnom području u nekoliko aspekata. Nova paradigma post-uzorkovanja temeljit će se na hibridnim kontinuirano-diskretnim modelima podataka i metodama obrade. Navedeno će omogućiti kontinuiranu obradu signala na digitalnom računalu bez diskretnih aproksimacija temeljenih na uzorcima. Osim toga, uvest će se novi optimalni i adaptivni pristupi mjerenju. Kako bi se prevladali određeni nedostaci redukcije dimenzionalnosti u sažimajućem očitavanju, uvest će se eksploratorna mjerenja.U novije vrijeme pristup temeljen na dubokom učenju rezultirao je brzim napretkom metoda nadziranog učenja. Stoga ćemo primijeniti metode strojnog učenja kako bismo postigli visoku kvalitetu i brzu CS rekonstrukciju signala. Rezultati našeg istraživanja donijet će poboljšanja u praktičnim primjenama kao što su snimanje iz višestrukih pogleda, snimanje svjetlosnog polja, 3D rekonstrukcija te medicinsko snimanje, odnosno pozitronska emisijska tomografija (PET). Snimanje svjetlosnog polja nadilazi mogućnosti klasične fotografije te omogućuje naknadnu obradu slika, primjerice promjenu gledišta, digitalno refokusiranje te virtualnu promjenu otvora blende. Korištenjem slika iz višestrukih pogleda, slika svjetlosnog polja te PET slika, naše istraživanje omogućit će točniju 3D rekonstrukciju.]]></summary_hr><summary_en><![CDATA[Signal sampling and reconstruction are a central part of the digital signal processing (DSP) - the sampling theorem provides a bridge between the continuous and discrete-time world in modern electronic devices, smartphones, cameras and medical equipment. Compressive sensing (CS) is a technique that relies on finite rate of innovation in order to reduce the number of measurements needed for statistically reliable reconstruction. Rapid advances in this research area bring a renaissance of the sampling theory, mostly due to its significance to the DSP community. Our research contributes to this challenging field in several aspects. New post-sampling paradigm will be based on hybrid continuous-discrete data models and processing methods. It will enable continuous signal processing on a digital computer without the discrete approximation based on samples. Moreover, novel optimal and adaptive measurement approaches will be introduced. Exploratory measurements will be proposed to overcome certain drawbacks of the CS dimensionality reduction. Recently, a deep learning based approach resulted in a rapid advance of supervised learning methods. We will apply machine learning methods to achieve high quality and fast CS reconstruction. Applications that will benefit from our research results are multi-view and light field imaging, 3D reconstruction and medical imaging, namely positron emission tomography (PET). Light field imaging goes beyond the conventional photography and enables powerful post-capture capabilities, such as change of viewpoint, digital refocusing, and virtual change of aperture. Our research will enable more accurate 3D reconstruction from multi-view, light field and PET images.]]></summary_en></project><project>
<id>9115</id><title_hr><![CDATA[Snaga i varijabilnost ekstremnih razina Jadranskog mora u sadašnjoj i budućoj klimi]]></title_hr><title_en><![CDATA[Strength and Variability of the Adriatic Sea Level Extremes in Present and Future Climates]]></title_en><user_id>829</user_id><user_firstLast_name>Jadranka Šepić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-5875</code><acronim><![CDATA[StVar-Adri]]></acronim><duration>01.12.2020 - 30.11.2024</duration><status>Završio</status><financ_value>80.355,43 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Geofizika, </scie_field_hr><scie_field_en>Geophysics, </scie_field_en><institution_hr><![CDATA[Institut za oceanografiju i ribarstvo]]></institution_hr><institution_en><![CDATA[Institute of Oceanography and Fisheries]]></institution_en><team_members_id>1315, 17732, 2898, 22609, 26894, 27328, 12559, 17753, 27146, 26904, 26980, </team_members_id><team_members_names><![CDATA[Iva Međugorac, Natalija Dunić, Miroslava Pasarić, Hrvoje Kalinić, Isaak Fain, Alexander Rabinovich, Frano Matić, Maja Bubalo, Marko Mlinar, Maja Karlović, Srđan Čupić, ]]></team_members_names><keywords_hr><![CDATA[razina mora, olujni uspor, tsunami, meteotsunami, regionalni klimatski modeli, neuronske mreže ]]></keywords_hr><keywords_en><![CDATA[sea level, storm surges, tsunami, meteotsunami, regional climate models, neural networks ]]></keywords_en><summary_hr><![CDATA[Jadranske poplave predstavljaju znatnu prijetnju za priobalne zajednice, kao i za jezgre mnogih povijesnih gradova i gradića. Posebno su ugrožena priobalna područja plitkog sjevernog Jadrana. U sjevernom Jadranu, najjače poplave poznate su kao “Aqua alta” (tal. “visoka voda”). Ugroženost jadranske obale uslijed poplava će se vjerojatno povećati do kraja 21.-og stoljeća, a zbog porasta srednje razine mora za koji se očekuje da će globalno iznositi između 40 i 60 cm. Jadranske poplave obično se javljaju zbog superpozicije brojnih procesa koji uključuju: dugotrajne trendove razine mora (periodi > 10 godina), međugodišnju varijabilnost (1-10 godina), sezonske procese, planetarne procese (10-100 dana), sinoptičke procese (6 sati-10 dana), plimne oscilacije (dominanto na periodima od ~12 te ~24 sata u Jadranu), jadranski seš (period ~21 sat), visoko-frekventne oscilacije razine mora (<6 sati) i vjetrovne valove. Unutar projekta StVar-Adri proučavat će se nekoliko aspekta jadranskih poplava, i to unutar četiri modula: (i) izdvajanje i analiza povijesnih događaja s fokusom na olujne uspore, meteotsunamije i tsunamije; (ii) uloga dugoperiodičke (planetarne) komponente vodostaja u jadranskim poplavama i njena svojstva u budućoj klimi; (iii) uloga jadranskog seša u jadranskim poplavama i njegova svojstva u budućoj klimi; i (iv) procjena doprinosa visoko-frekventnih oscilacija razine mora poplavama i njihova svojstva u budućoj klimi. Kako bi se postigli projektni ciljevi, primijenit će se ove metodologije: (i) prikupljanje i kontrola povijesnih podataka; (ii) numeričko modeliranje; (iii) analiza produkata klimatskih modela; i (iv) analize putem neuronskih mreža. Planirana je suradnja između nekoliko istraživačkih grupa koje se sastoje od znanstvenika koji se bave ekstremnim razinama mora, analizom podataka i numeričkim modeliranjem. ]]></summary_hr><summary_en><![CDATA[The Adriatic extreme flooding events represent a considerable threat for coastal communities and historical town centres, especially along the coast of the shallow northern Adriatic where these events are known as “Aqua Alta” (It. “high water”). The threat is expected to further increase by the end of the 21st century, due to mean sea level rise which is projected to amount to 40-60 cm worldwide. The Adriatic floods normally develop due to a superposition of numerous processes including: long-term sea level trends (periods > 10 years), interannual variability (1-10 years), seasonal processes, planetary processes (10–100 days), synoptic processes (6 hours–10 days), tidal oscillations (dominantly at ~12 and ~24 hours in the Adriatic), Adriatic seiche (period of ~21 hours), high-frequency sea level oscillations (< 6 hours) and wind waves. Within project StVar-Adri several aspects of extreme flooding events will be studied within the 4 project modules: (i) assessing historical extreme flooding events with focus on storm surge events, meteotsunamis and tsunamis; (ii) estimating present-day and future contribution of planetary component of sea level to the Adriatic floods and sea level variability; (iii) estimating present-day and future contribution of the Adriatic seiche to flooding and sea level variability; and (iv) estimating present-day and future contribution of high-frequency processes to the flooding events and the Adriatic sea level variability. In order to achieve project goals, following methodologies will be applied: (i) collection and quality control of historical data; (ii) numerical ocean modelling; (iii) analysis of outputs of climate models; and (iv) neural network analysis. A strong collaboration between several research groups consisting of experts in sea level extreme, data analysis methods and numerical modelling is planned. ]]></summary_en></project><project>
<id>9122</id><title_hr><![CDATA[Ličnost, emocije i radna uspješnost nastavnika: dinamička perspektiva]]></title_hr><title_en><![CDATA[Teacher personality, emotion and performance: A dynamic perspective]]></title_en><user_id>6118</user_id><user_firstLast_name>Irena Burić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-5472</code><acronim><![CDATA[TEPEPDYN]]></acronim><duration>01.01.2020 - 31.08.2024</duration><status>Završio</status><financ_value>74.982,41 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Psihologija, </scie_field_hr><scie_field_en>Psychology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zadru]]></institution_hr><institution_en><![CDATA[University of Zadar]]></institution_en><team_members_id>3634, 26848, 26831, 6601, 5908, 6241, 22497, 21321, 858440, 865284, </team_members_id><team_members_names><![CDATA[Ana Butković, Anne Frenzel , Lisa Kim, Maja Parmač Kovačić, Zvjezdan Penezić, Izabela Sorić, Barbara Brdovčak, Mara Šimunović, Aleksandra Huić, Krešimir Jakšić, ]]></team_members_names><keywords_hr><![CDATA[nastavnici, ličnost, emocije, regulacija emocija, radna uspješnost, dinamička perspektiva]]></keywords_hr><keywords_en><![CDATA[teachers, personality, emotions, emotion regulation, performance, dynamic perspective]]></keywords_en><summary_hr><![CDATA[Posljednjih godina istraživanja emocija i emocionalne regulacije nastavnika su u stalnom porastu. Prepoznato je kako su različite diskretne emocije nastavnika i strategije emocionalne regulacije povezane s dobrobiti nastavnika, njihovom radnom uspješnošću i učeničkim ishodima. Unatoč ovim značajnim spoznajama, još je uvijek potrebno odgovoriti na velik broj važnih pitanja. Primjerice, istraživanja o ulozi emocija nastavnika i emocionalne regulacije u predviđanju njihove kvalitete poučavanja i učeničkih kognitivnih, afektivnih i motivacijskih ishoda su i dalje rijetka i gotovo isključivo temeljena na transverzalnim nacrtima pomoću kojih se ne mogu utvrditi uzročni mehanizmi u podlozi. Uz to, uzimajući u obzir činjenicu da osobine ličnosti utječu na emocije i emocionalnu regulaciju te radnu uspješnost nastavnika, istraživanja uloge stabilnijih karakteristika ličnosti nastavnika u predviđanju njihovih emocionalnih procesa i radne uspješnosti od velike je važnosti. Na kraju, unatoč tome što suvremene teorije emocija jasno naglašavaju njihovu dinamičku i prilagodljivu prirodu i da noviji teorijski okviri ličnosti naglašavaju dinamičku integraciju crta, konteksta i trenutnih psiholoških stanja, emocije nastavnika i emocionalna regulacija do sada su uglavnom bile definirane kao stabilne crte ili kao kratkotrajna stanja statična u vremenu. Stoga je cilj ovog projekta istražiti ulogu emocija nastavnika i emocionalne regulacije u objašnjenju njihove radne uspješnosti vodeći pritom računa o učincima stabilnih osobina ličnosti i promjenjivih situacijskih karakteristika te uzimajući u obzir dinamičnu prirodu emocionalnih iskustava nastavnika. Kako bi se postigao ovaj cilj, prikupit će se podaci od nastavnika i njihovih učenika te će se implementirati sofisticirane longitudinalne metode kako bi se utvrdili uzročni mehanizmi u podlozi koji bi mogli objasniti povezanosti između konstrukata koji se istražuju.]]></summary_hr><summary_en><![CDATA[In recent years, research on teacher emotion and emotion regulation has been steadily progressing. Varieties of discrete teacher emotions and emotion regulation strategies have been recognized to relate to teacher well-being, their performance, and student outcomes. In spite of these important insights, many questions are yet to be addressed. For example, the empirical evidence regarding the role of teachers’ emotions and emotion regulation in predicting their instructional quality and students’ cognitive, affective, and motivational outcomes are still rather scarce and almost exclusively based on cross-sectional designs that cannot reveal underlying causal mechanisms. In addition, considering the fact that personality traits are recognized to affect emotions and emotion regulation, as well as teacher performance, investigation the role of teacher more stable personality characteristics in predicting their emotional processes and performance is of great importance. Lastly, even though contemporary theories on emotions readily acknowledge their dynamic and malleable nature and that emerging personality frameworks emphasize the dynamic integration of traits, contexts, and momentary psychological states, teachers’ emotions and emotion regulation have been mostly conceptualized as stable traits or as brief states static in time. Therefore, the current project proposal aims to explore the role of teachers’ emotions and emotion regulation in explaining their performance while acknowledging the effects of stable personality dispositions and malleable situational characteristics and considering the dynamic nature of teachers’ emotional lives. In order to achieve this aim, data from teachers and their students will be collected and sophisticated longitudinal methods will be implemented to reveal the underlying causal mechanisms that can explain the associations between the constructs under study. ]]></summary_en></project><project>
<id>9127</id><title_hr><![CDATA[Novi aspekti dnevno-noćne vertikalne migracije zooplanktona u složenom ekosustavu otvorenoga južnoga Jadrana]]></title_hr><title_en><![CDATA[New aspects of diel vertical migration of zooplankton in the complex open South Adriatic ecosystem ]]></title_en><user_id>1051</user_id><user_firstLast_name>Mirna Batistić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-9043</code><acronim><![CDATA[DiVMAd]]></acronim><duration>01.03.2020 - 01.08.2024</duration><status>Završio</status><financ_value>121.109,56 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Interdisciplinarne prirodne znanosti, Fizika, Kemija, Biologija, Geofizika, </scie_field_hr><scie_field_en>Interdisciplinary natural sciences, Physics, Chemistry, Biology, Geophysics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Dubrovniku]]></institution_hr><institution_en><![CDATA[University of Dubrovnik]]></institution_en><team_members_id>26178, 1519, 26186, 26182, 26790, 26180, 4923, 13469, 3160, 2977, 2979, 7600, 3992, 2889, 27190, 866654, </team_members_id><team_members_names><![CDATA[Laura Ursella, Marijana Hure, Vanessa Rossana  Cardin, Stefano Miserocchi, Tjaša Kogovšek, Elena Mauri, Valter Kožul, Giuseppe Civitarese, Rade Garić, Iris Dupčić Radić, Ana Car, Miroslav Gacic, Jakica Njire, Nenad Jasprica, Priscilla Licandro, Nika Pasković, ]]></team_members_names><keywords_hr><![CDATA[Jadransko more, zooplankton, dnevno-noćne migracije, prijenos ugljika, BIOS mehanizam]]></keywords_hr><keywords_en><![CDATA[Adriatic Sea, zooplankton, diel vertical migration, carbon flux, BiOS mechanism]]></keywords_en><summary_hr><![CDATA[Dnevna vertikalna migracija (DVM) jest sinkronizirano kretanje zooplanktona gore i dolje u vodenom stupcu tijekom dnevnog ciklusa i vjerojatno je najveće prirodno dnevno kretanje biomase na Zemlji. Budući da zooplankton predstavlja trofičku vezu između primarnih proizvođača (tj. fitoplanktona u osvijetljenoj fotičkoj zoni) i višim trofičkim razinama do vršnih predatora (riba), razumijevanje njihovih migracijskih obrazaca i vertikalne raspodjele biomase od ključne je važnosti za razumijevanje funkcioniranja pelagičkog ekosustava. Dosada su detaljne informacije o DVM zooplanktona u Jadranskom moru, kao i u cijelom Sredozemlju, bile vrlo rijetke. Novi pristup u istraživanju će kombiniranjem širokopojasnih akustičnih tehnika (engl. Acoustic Current Doppler Profiler, ADCP), mrežnog uzorkovanja i optičkih tehnika omogućiti dobivanje visoko razlučive vremenske serije o abundanciji i sastavu te raspodjeli zooplanktona, od površine do mezopelagičkog sloja. To omogućuje određivanje migracijskih vrsta i migracijskog ponašanja te dobivanje najtočnijih podataka za razumijevanje fenomena DVM zooplanktona. Uočeni obrasci raspodjele zooplanktona bit će povezani s fizikalnim i biološkim okolišnim uvjetima (npr. dnevnom svjetlošću, mjesečinom, BiOS mehanizmom, strujama, vertikalnim miješanjem, stratifikacijom, potpovršinskom (dubokom) maksimumu klorofila, izvoru hrane), uključujući partikularni organski ugljik (POC) sakupljen u sedimentnim zamkama. Općenito, moći ćemo procijeniti doprinos migracije zooplanktona u vertikalnom prijenosu ugljika u različitim razdobljima i ekološkim uvjetima. Unaprijeđivanje postojećih spoznaja o raspodjeli planktona, ekologiji i bioraznolikosti trebalo bi nam pomoći u praćenju budućih promjena planktonske zajednice u Jadranskom moru, a koje pokreću različiti cirkulacijski režimi i klimatske promjene. To će, također, pomoći pri praćenju sličnih učinaka na zajednice riba, što je poglavito važno za upravljanje ribarstvom i gospodarstvo.]]></summary_hr><summary_en><![CDATA[Diel vertical migration (DVM) is the synchronised movement of zooplankton up and down in the water column over a daily cycle and it is likely the largest natural daily movement of biomass on the Earth. Since zooplankton represents the trophic link between primary producers (i.e. phytoplankton in the photic zone) and higher trophic levels up to top predators (e.g. fish), the comprehension of their migratory patterns and vertical biomass distribution is of crucial importance in understanding the pelagic ecosystem functioning. So far detailed information on zooplankton DVM in the Adriatic Sea, as in the whole Mediterranean basin, are very rare. To fill this knowledge gap we propose to develop a novel approach that combining broadband acoustics (ADCP), net sampling and optical techniques, will produce high-resolution time series of zooplankton abundance/composition and distribution, from the surface to the mesopelagic layer in the open southern Adriatic. This allow us to identify migrating species and its migrating behaviour and to get the most accurate data sets for understanding phenomenon of zooplankton diel vertical migration. The observed distribution patterns of zooplankton DVM will be related to the physical/biological environmental conditions, (e.g. daylight, moonlight, BiOS mechanisms, currents, vertical mixing, stratification, deep chlorophyll maximum, food resources) including particulate organic carbon (POC) collected in sediment traps. Overall, we will be able to assess the contribution of zooplankton migration to vertical carbon export under different periods and environmental scenarios. Improving current knowledge on plankton distribution, ecology and biodiversity should help us track future plankton community changes in the Adriatic Sea driven by different circulation patterns and on-going climate change. This will also help in tracking the related effects on fishes communities which is important for fisheries management and the economy.]]></summary_en></project><project>
<id>9128</id><title_hr><![CDATA[Izloženost piretroidnim i organofosfatnim insekticidima u djece - procjena rizika od štetnih učinaka na neuropsihološki razvoj i hormonski status]]></title_hr><title_en><![CDATA[Exposure to pyrethroid and organophosphate insecticides in children – risk assessment for adverse effects on neuropsychological development and hormonal status]]></title_en><user_id>5544</user_id><user_firstLast_name>Veda Marija Varnai</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-7193</code><acronim><![CDATA[PyrOPECh]]></acronim><duration>01.02.2020 - 25.03.2025</duration><status>Završio</status><financ_value>123.708,28 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Javno zdravstvo i zdravstvena zaštita, </scie_field_hr><scie_field_en>Public health and health services, </scie_field_en><institution_hr><![CDATA[Institut za medicinska istraživanja i medicinu rada]]></institution_hr><institution_en><![CDATA[Institute for Medical Research and Occupational Health]]></institution_en><team_members_id>4799, 13074, 3911, 879, 24190, 1209, 26193, 26592, 6431, 26502, 12667, 4573, 2514, 26474, 26486, 26411, 26717, 18906, 3765, 26436, 26910, 3660, 27367, 21444, 856213, 12504, 865024, 20238, </team_members_id><team_members_names><![CDATA[Jelena Kovačić, Adrijana Bjelajac (Košćec), Selma Cvijetić Avdagić, Jelena Macan, Rajka Turk, Željka Babić, Jim Garvey, Marija Posavec, Vera Musil, Bernarda Krnić, Marijana  Matek Sarić, Irena Keser, Saša Kralik Oguić, Iva  Bebek, Gordana Jurak, Tatjana Petričević-Vidović, Anne Nugent, Matijana  Jergović (born Grgic), Romana Gjergja Juraški, Snježana  Sekušak-Galešev, Breige McNulty, Katja Dumić Kubat, Brendan Murray, Andreja Jurič, Marija Macan, Antonija Sulimanec Grgec, Patricia Tomac, Eva Anđela Delale, ]]></team_members_names><keywords_hr><![CDATA[insekticidi, metaboliti pesticida u urinu, procjena izloženosti hranom, procjena rizika, neuropsihološki razvoj]]></keywords_hr><keywords_en><![CDATA[insecticides, biomonitoring, dietary exposure assessment, risk assessment, neuropsychological development, pubertal development]]></keywords_en><summary_hr><![CDATA[Epidemiološka istraživanja i pokusi na životinjama upućuju na moguće štetne učinke piretroidnih (PYR) i organofosfatnih (OP) insekticida na razvoj mozga i spolni razvoj u djece, čak i pri vrlo niskim razinama izloženosti. Međutim, moguća povezanost izloženosti pesticidima s navedenim zdravstvenim parametrima malo je istraživana za razdoblje puberteta, uz nejednoznačne rezultate i znatna metodološka ograničenja, kao što su nedovoljno definirana izloženost i presječni dizajn studija.   Glavni cilj predloženog projekta je procijeniti rizik od štetnih učinaka izloženosti PYR i OP insekticidima na neuropsihološki razvoj i hormonski status dječaka u predpubertetu i pubertetu u 2-godišnjoj kohortnoj studiji, uz kontrolu za potencijalne čimbenike utjecaja, koristeći isključivo neinvazivne metode. Izloženost djece PYR i OP insekticidima procjenjivat će mjerenjem njihovih metabolita u urinu u 5. i 7. razredu osnovne škole, te procjenom unosa pesticida hranom pomoću 24-satnog prisjećanja o prehrani u pet navrata tijekom 2-godišnjeg praćenja. U 5. i 7. razredu osnovne škole procjenjivat će se neuropsihološki razvoj testiranjem pažnje, pamćenja i brzine jednostavne psihomotorne reakcije, procjenom karakteristika spavanja i neurobihevioralnog funkcioniranja, a pubertetski razvoj procjenjivat će se pomoću kliničkog pregleda (po Tanneru i Praderu), mjerenja gonadotropina u urinu te spolnih hormona (testosterona i dehidroepiandrosteron sulfata) u slini.  Očekuje se da će istraživanje doprinijeti 1) razumijevanju rizika od mogućih štetnih učinaka PYR i OP insekticida na neuropsihološki razvoj i hormonski status dječaka u pubertetu; 2) prepoznavanju nedostataka i unaprjeđenju danas raspoložive metodologije ocjenjivanja razvojne neurotoksičnosti i endokrine disrupcije u okviru regulatorne toksikologije; 3) razvoju metodologije za procjenu izloženosti pesticidima koji nemaju osobinu nakupljanja u tijelu; 4) boljoj karakterizaciji izloženosti pesticidima u hrvatskoj populaciji.  ]]></summary_hr><summary_en><![CDATA[Epidemiological studies and animal experiments indicate the potential adverse effects of exposure to pyrethroid (PYR) and organophosphate (OP) insecticides on brain and sexual development in children, even at very low exposure levels. However, limited number of studies explored these potential risks during puberty, with inconsistent results and significant methodological limitations, such as insufficiently assessed exposure and cross-sectional study design.The main objective of the proposed research is to assess the risk of PYR and OP insecticide exposure to neuropsychological development and hormonal status in prepubertal and pubertal boys in a 2-year cohort study, while controlling for potential confounders, and using only non-invasive methods.Children’s exposure to PYR and OP insecticides will be assessed by biomonitoring (analysing urinary pesticide metabolites) in the 5th and 7th grades of elementary school, and by dietary exposure assessment - 24-hour dietary recall on five occasions during 2-year follow-up. In the 5th and 7th grades, neuropsychological development will be evaluated by testing attention, memory and simple psychomotor response speed, and by assessing the characteristics of child’s sleep and behaviour. Pubertal development will be evaluated by clinical examination (according to Tanner and Prader), and urinary gonadotropins and salivary sex hormones (testosterone and dehydroepiandrosterone sulfate) measurements. The research is expected to 1) increase the knowledge on possible risks of PYR and OP insecticides’ exposure for neurodevelopment and hormonal status in pubertal boys; 2) help to recognise deficiencies and assess available methodology for evaluation of developmental neurotoxicity and endocrine disruption within the framework of regulatory toxicology; 3) improve insufficient methodology for exposure assessment of non-bioaccumulative pesticides; 4) contribute to the better characterisation of pesticide exposure in the Croatian population.]]></summary_en></project><project>
<id>9132</id><title_hr><![CDATA[Sustavni pristup modelima konsenzualne pravde u hrvatskom kaznenom postupku]]></title_hr><title_en><![CDATA[Systematic Approach to Models of Negotiated Justice in Croatian Criminal Procedure]]></title_en><user_id>6657</user_id><user_firstLast_name>Elizabeta Ivičević Karas</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-1275</code><acronim><![CDATA[NegJusCro]]></acronim><duration>03.01.2020 - 02.01.2024</duration><status>Završio</status><financ_value>40.288,94 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Pravo, </scie_field_hr><scie_field_en>Law, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Pravni fakultet u Zagrebu]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Law]]></institution_en><team_members_id>6266, 7173, 6285, 3315, 7456, 816, 6110, 19800, 865285, </team_members_id><team_members_names><![CDATA[Zlata Đurđević, Marin Bonačić, Zoran  Burić, Igor Martinović, Ante Novokmet, Matko Pajčić, Marija Pleić, Ivana Radić, Darija Željko, ]]></team_members_names><keywords_hr><![CDATA[konsenzualni postupci, konsenzualna pravda, nagodbe, kazneni postupak, kazneno pravosuđe]]></keywords_hr><keywords_en><![CDATA[consensual procedures, consensual justice, plea bargaining, criminal procedure, criminal justice]]></keywords_en><summary_hr><![CDATA[Hrvatski je zakonodavac posljednjih godina, pod utjecajem raznih stranih modela, uvodio različite oblike konsenzualnih postupaka, postupno šireći područje njihove primjene. Iz do sada provedenih istraživanja, moguće je uočiti da zakonodavac nije bio dosljedan kada je uređivao njihove različite aspekte koji se primjerice odnose na težinu kaznenih djela za koja je moguć pojedini oblik sporazuma, ulogu suda, ulogu žrtve, prava obrane i drugo. Poseban problem predstavlja to što nisu jasno izdiferencirani, niti na legislativnoj razini niti u praksi, specifični ciljevi koje bi pojedini oblici sporazumijevanja trebali ostvarivati. Nepreciznost i nekonzistentnost u regulaciji temeljnih aspekata različitih oblika konsenzualnih postupaka ne doprinose transparentnosti i kvaliteti kaznenog pravosuđa te u konačnici narušavaju povjerenje građana u pravosuđe. Predloženo istraživanje omogućit će sustavnu analizu problematike nagodbi primjenom temeljnih znanstvenih metoda. Nakon teorijske, normativne i poredbene analize, te istraživanja sudske i državnoodvjetničke prakse različitih oblika sporazumijevanja, provest će se empirijsko istraživanje primjenom metode polustrukturiranih intervjua te fokus grupa s ključnim sudionicima: sucima, državnim odvjetnicima i odvjetnicima. Iskustva ispitanika doprinijet će detektiranju i analizi ključnih nedostataka postojećeg normativnog okvira i prakse nagodbi. Završna studija u okviru projekta sintetizirat će rezultate provedenih istraživanja te će ponuditi konkretne prijedloge za izgradnju konzistentnog zakonskog okvira i transparentne prakse konsenzualnih postupaka, u skladu s europskim pravnim standardima i temeljnim načelima suvremenog kaznenog postupka.]]></summary_hr><summary_en><![CDATA[The Croatian legislator has lately introduced various forms of consensual procedures, influenced by foreign models, and has gradually expanded the scope of their application. From previous researches, it is possible to conclude that the legislator was not consistent when addressing various aspects of these proceedings, regarding for example the gravity of criminal offenses for which a particular form of agreement is possible, the role of the court, the role of the victim, the defence rights etc. A particular problem is that there are no clear distinctions, either at the legislative level or in practice, of the specific objectives of certain forms of agreements. Imprecision and inconsistency in the regulation of the fundamental aspects of various forms of consensual procedures do not contribute to the transparency and quality of the criminal justice and ultimately disturb citizens&#39; trust in criminal justice system. The proposed research will provide a systematic analysis of consensual justice, using basic scientific methods. After theoretical, normative and comparative analysis, as well as after the research of judicial and state attorneys’ practices of various consensual forms, an empirical research will be conducted using the method of semi-structured interviews and focus groups with key participants: judges, state attorneys and attorneys. The experience of the respondents will contribute to detecting and analysing the key deficiencies of the existing normative framework and practice. The final study will synthesize the results of the researches and will offer concrete proposals for building a consistent legal framework and transparent practices of consensual procedures in accordance with European legal standards and basic principles of contemporary criminal proceedings.]]></summary_en></project><project>
<id>9133</id><title_hr><![CDATA[Mjeriteljska infrastruktura za potporu inteligentnoj energetskoj mreži]]></title_hr><title_en><![CDATA[Metrology infrastructure for support of the intelligent power grid]]></title_en><user_id>5372</user_id><user_firstLast_name>Roman Malarić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-7354</code><acronim><![CDATA[INTELIGRID]]></acronim><duration>16.12.2019 - 15.12.2023</duration><status>Završio</status><financ_value>88.406,66 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, Temeljne tehničke znanosti, </scie_field_hr><scie_field_en>Electrical engineering, Basic engineering sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>142, 5483, 5389, 3516, 3230, 4309, 5507, 1370, 21317, </team_members_id><team_members_names><![CDATA[Marko Jurcevic, Kruno Miličević, Petar Mostarac, Tonko Garma, Goran Petrović, Marin Despalatović, Hrvoje Hegeduš, Dubravko Sabolić, Jure Konjevod, ]]></team_members_names><keywords_hr><![CDATA[inteligentna energetska mreža, mjeriteljstvo, precizne mjerne metode, mjerenje snage, mjerenje energije, algoritmi obrade signala, PMU, sinkrofazor]]></keywords_hr><keywords_en><![CDATA[intelligent grid, metrology, precise measurement methods, measurement of power, measurement of energy, DSP algorithms, PMU, synchrophasor ]]></keywords_en><summary_hr><![CDATA[Opskrba električnom energijom iz obnovljivih izvora energije nije stabilna zbog same prirode izvora energije koji koriste. Ukoliko se takvi izvori pažljivo ne mjere i neprekidno nadziru, sve veća primjena takvih izvora dovesti će do smanjenja kvalitete električne energije, nestabilnosti elektroenergetskog sustava (EES) s mogućnošću povremenih raspada sustava i prekida u isporuci električne energije.Glavni ciljevi projekta predstavljaju:1) izrada i ispitivanje algoritama obrade mjerenja signala dobivenih s mreže PMU uređaja raspoređenih u EES-u,2) razvoj istraživačkog modela i prototipa uređaja PMU,3) razvoj sustava za ispitivanje i umjeravanje jedinica PMU primjenjivog u laboratoriju te kasnije u izvedbi prikladnoj za primjenu za udaljeno ispitivanje i umjeravanje.Predvidivo je načiniti algoritam (tj. grupu algoritama) za obradu podataka o kvaliteti električne energije i stanju EES-a (podacima o naponu, struji, frekvenciji i fazi) koje prikupljaju jedinice PMU, a koji se izvode na ugradbenim računalima te moraju imati brži odaziv od postojećih. Osim toga, cilj je, primjenom evolucijskih algoritama, načiniti algoritam koji će moći u skoro pa stvarnom vremenu locirati izvore nestabilnosti EES-a temeljem podataka dobivenih iz mreže PMU-ova. Predviđena izrada dvaju prototipova jedinica PMU što će omogućiti ispitivanje razvijenih mjernih algoritama na stvarnim modelima uređajima (dakle ne isključivo u računalnim simulacijama), a omogućiti će i ispitivanje sustava za umjeravanje jedinica PMU.Očekivani učinak istraživanja nalazi se u konkretnim znanstvenim doprinosima modernom načinu nadzora, zaštite i upravljanja EES-om, a koji je temeljen na mjernim podacima dobivenima s jedinica PMU (sinkrofazorima) u stvarnom vremenu. Tako će ovako zamišljen projekt predstavljati zaokruženu istraživačku cjelinu dosadašnjeg rada istraživačkih grupa, te povećati konkurentnost hrvatskih stručnjaka u svjetskim istraživačkim krugovima u navedenom području.]]></summary_hr><summary_en><![CDATA[Supply from renewable energy sources is unstable considering the source of the energy they convert. If those sources are left unsupervised and unchecked, the increase of their use will result in deterioration of power quality (PQ), instability of electric power system (EPS) with the possibility of situational system failure and disruption of the electrical energy distribution system.The main goals of the project are:1)	designing and testing an algorithm for processing of signals obtained from PMU units, and signals obtained from a PMU device network deployed in the EPS,2)	development of the research model and prototype of the PMU,3)	development of a system for testing and calibration of PMU units applicable in the laboratory and later on, in a form suitable for remote testing and calibration.It is envisaged to create a group of algorithms for processing data on the quality of electrical energy and state of the EPS (voltage, current, frequency, phase) coming from many PMU units, which are performed on embedded computers and must have a faster response than the existing ones. Additionally, using evolutionary algorithms, the goal is to create algorithms that will be able to locate instances of EPS instability in near real-time.It is envisaged to produce two PMU prototypes that will enable testing of developed measurement algorithms on real devices (ie not exclusively in computer simulations), and will also enable testing of the PMU calibration system.The expected impact of the research lies in concrete contributions to the modern way of monitoring, protecting and managing EPS, based on the metering data obtained from PMU units (synchrophazors) in real time. This activity will also provide the basis for new research in the area of monitoring and measurement of components in EPS, which will be funded from future projects. This way, the proposed project will represent the completion of the previous research as well as future planned work of research groups. ]]></summary_en></project><project>
<id>9135</id><title_hr><![CDATA[Brzi prekidački pretvornici zasnovani na GaN elementima i rezonantnim arhitekturama]]></title_hr><title_en><![CDATA[Fast switching converters based on GaN devices and resonant architectures]]></title_en><user_id>7714</user_id><user_firstLast_name>Adrijan Barić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-8959</code><acronim><![CDATA[FASCON]]></acronim><duration>01.06.2020 - 31.05.2024</duration><status>Završio</status><financ_value>192.448,07 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>7123, 13703, 27319, 13704, 855619, </team_members_id><team_members_names><![CDATA[Igor Krois, Raul Blečić, Vlatko Galić, Tvrtko  Mandić, Jurica Kundrata Kundrata, ]]></team_members_names><keywords_hr><![CDATA[prekidački pretvornik, GaN, galij-nitrid, rezonantni pretvornik, integrirani sklop, čip ]]></keywords_hr><keywords_en><![CDATA[switching converter, GaN, gallium-nitride, resonant converter, integrated circuit, chip]]></keywords_en><summary_hr><![CDATA[Prekidački pretvornici vrlo su značajni u modernoj elektronici za prenosive uređaje i za automobilsku elektroniku zbog njihove visoke efikasnosti. Kroz ovaj projekt razvijaju se metode za smanjenje generiranih elektromagnetskih (EM) smetnji kod rezonantnih pretvornika dok se u isto vrijeme održava visoka efikasnost. Analizira se više pristupa. Korištenje tehnike raspršenog spektra poboljšava elektromagnetsku kompatibilnost (EMC), ali može narušiti druge karakteristike pretvornika, npr. efikasnost. Modulacija s raspršenim spektrom je u komercijalnim pretvornicima uobičajeno fiksirana i njeni parametri se ne mogu podešavati. Korištenjem konfigurabilne modulacije raspršenog spektra mogu se smanjiti EM emisije bez žrtvovanja ostalih karakteristika. Drugo, korištenje galij-nitrid (GaN) tranzistora u prekidačkim pretvornicima umjesto silicijskih tranzistora smanjuje gubitke i omogućava rad pretvornika na višim prekidačkim frekvencijama. Zatim se istražuje utjecaj omjera ulaznog i izlaznog napona na efikasnost i EM emisije kod pretvornika koji rad ne visokim prekidačkim frekvencijama i koji se sastoje od više stupnjeva. Mjerenja prekidačkih pretvornika vrlo su zahtjevna, prije svega zbog mjerenja tranzistora na gornjoj strani, a osim toga i mjerenja EM smetnji. U ovom projektu razvija se cjelovito elektro-optičko mjerno okruženje za karakterizaciju elektromagnetske kompatibilnosti i mjerenje prekidačkih tranzistora. Provodi se analiza elektro-optičkog sustava kroz procjenu karakteristika te korisnosti pri mogućem komercijalnom korištenju sustava. Predloženo istraživanje ispituje metode optimiranja efikasnosti prekidačkih pretvornika snage uz održavanje elektromagnetskih emisija unutar dozvoljenih granica korištenjem novih elektroničkih elemenata i arhitektura istosmjernih pretvornika snage.]]></summary_hr><summary_en><![CDATA[Switching converters are very important in modern electronics because of their high efficiency in portable applications and in automotive electronics. This project aims to provide the methods for the reduction of the generated electromagnetic (EM) interference of the resonant converters while keeping their high efficiency. Several approaches are analyzed. Utilization of a spread-spectrum technique improves electromagnetic compatibility (EMC), but it may deteriorate other characteristics of the converter, e.g. the efficiency. The spread-spectrum modulation in commercially available converters is usually fixed and its parameters are not user-configurable. Having a configurable spread-spectrum modulator allows  fine tuning and reduction of  generated EM emissions without having to sacrifice the performance. Secondly, using gallium-nitride (GaN) transistors in switching power converters instead of silicon ones leads to lower power losses and operation of the converters at even higher switching frequencies. Thirdly, the investigation on the impact of the voltage conversion ratio on power efficiency and electromagnetic emissions in the high-frequency multi-stage DC-DC converter chain is performed. Finally, measurements of switching converters are very demanding, firstly because of the measurements of the high side transistors and secondly because of strong conducted and radiated electromagnetic emissions. In this project, an entire electro-optical measurement environment for characterization of electromagnetic compatibility and measurement of transistor switches is developed and its usage is fully assessed from the viewpoint of technical specifications and commercial usefulness. The proposed research investigates the methods for optimization of power efficiency of switching power supplies while meeting the acceptable levels of electromagnetic emissions using novel device technologies and architectures of DC-DC power converters.]]></summary_en></project><project>
<id>9147</id><title_hr><![CDATA[Biomimetički inteligentni kompozitni materijali]]></title_hr><title_en><![CDATA[Biomimetic intelligent composite materials]]></title_en><user_id>7666</user_id><user_firstLast_name>Zrinka  Tarle</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-6183</code><acronim><![CDATA[BIOMICS]]></acronim><duration>01.01.2020 - 31.12.2023</duration><status>Završio</status><financ_value>187.510,32 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Dentalna medicina, Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Dental medicine, Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Stomatološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Dentistry]]></institution_en><team_members_id>26045, 19740, 26086, 27329, 26772, 26658, 26917, 23492, 12826, 26637, 26687, 26624, </team_members_id><team_members_names><![CDATA[Danijela Marović, Eva Klarić Sever, Matej Par, Višnja Negovetić Mandić, Vlatko Pandurić, Attin Thomas, Tobias Tauböck, Goran Pichler, Rozelindra Čož-Rakovac, Ivana Šutej, Kristina Peroš, Josipa Vukelja, ]]></team_members_names><keywords_hr><![CDATA[bioaktivni kompozitni materijali, remineralizacija, sekundarni karijes, biomimetika, polimerizacija, mehanička svojstva]]></keywords_hr><keywords_en><![CDATA[bioactive composite materials, remineralization, secondary caries, biomimetics, polymerization, mechanical properties]]></keywords_en><summary_hr><![CDATA[Sekundarni karijes, karijes oko zubnih restauracija, najčešći je razlog za njihovu zamjenu, u čak do 70% zamijenjenih restauracija. Bioaktivni remineralizirajući kompozitni materijali sa sposobnošću otpuštanja iona i potencijalom izgradnje oštećene zubne strukture, imitacijom prirodnih procesa mineralizacije, bili bi temelj našeg rada i strategija prevencije sekundarnog karijesa. Osnovni nedostatak većine remineralizirajućih kompozita je njihova slaba mehanička snaga i brža degradacija u oralnoj sredini, što je uglavnom uzrokovano prisutstvom nesilaniziranih, topivih punila koja otpuštaju ione. U predloženom projektu, ovaj problem pokušat će se ublažiti modifikacijom smolaste matrice i/ili inkorporacijom nekoliko vrsta bioaktivnih i inertnih punila i vlakana, uključujući specifično formulirana bioaktivna staklena punila. Najnoviji komercijalno dostupni materijali i polimerizacijska svjetla bit će upotrijebljena za usporedbu podataka. Nove eksperimentalne kompozitne formulacije bit će podvrgnute opsežnoj evaluaciji njihovog remineralizacijskog potencijala, mehaničkih svojstava, polimerizacijske kinetike, apsorpcije vode i topljivosti, transmisije svjetlosti, porasta temperature i sveze za tvrda zubna tkiva. Većina planiranih ispitivanja provest će se tijekom jedne godine kako bi se moglo procijeniti dugoročno ponašanje. Sve navedeno trebalo bi pridonijeti boljem razumijevanju odnosa sastav-struktura-svojstvo i optimizaciji sastava kompozita u budućim ispitivanjima kako bi se ova obećavajuća skupina biomaterijala što više približila kliničkoj primjeni. Posljedice sekundarnog karijesa su fizička bol, samosvjesnost zbog vlastitog izgleda i značajan financijski teret pacijentu, njegovom poslodavcu, zdravstvenom osiguranju i državnoj ekonomiji. Ova neželjena serija događaja mogla bi se spriječiti prevencijom sekundarnog karijesa i poboljšanjem kvalitete života pacijenata s našim bioaktivnim kompozitnim materijalima.]]></summary_hr><summary_en><![CDATA[Secondary caries, caries surrounding dental fillings, is the most common reason for their replacement, amounting up to 70% of replaced fillings. Bioactive remineralizing composite materials with the ion-releasing ability and the potential to build up destructed tooth structure by imitation of naturally occurring process of mineralization will be the foundation of our work and a strategy for secondary caries prevention. The main shortcoming of the majority of remineralizing composites is their lower mechanical strength and faster degradation in oral environment, mainly caused by the presence of unsilanized, soluble, ion-releasing fillers. In the proposed project, this issue would be addressed by the modification of resinous matrix and/or incorporation of several kinds of bioactive and inert fillers and fibers, including specifically formulated bioactive glass fillers. The latest commercially available materials and polymerization lights would be used for comparison. New experimental composite formulations would be subjected to comprehensive evaluation of their remineralizing potential, mechanical properties, polymerization kinetics, water sorption and solubility, light transmission, temperature rise and bond to hard dental tissues. Most of the planned studies would be conducted during one year so that long-term behavior could be assessed. This should all contribute to better understanding of the composition-structure-property relationship and optimizing composite formulations in further studies, which should bring this promising class of biomaterials a step closer to clinical applicability. The repercussions of secondary caries are physical pain, self-consciousness due to personal appearance and significant financial burden for patients, their employers, health insurance and the state economy. This unwanted series of events could be averted by preventing secondary caries and improving the quality of life of our patients with our bioactive dental composite materials.]]></summary_en></project><project>
<id>9152</id><title_hr><![CDATA[Bentoske nezavičajne vrste u hrvatskom dijelu Jadranskog mora]]></title_hr><title_en><![CDATA[Benthic Non-Indigenous Species in the Croatian region of the Adriatic Sea]]></title_en><user_id>4777</user_id><user_firstLast_name>Ante Žuljević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-6702</code><acronim><![CDATA[BenthicNIS]]></acronim><duration>15.01.2020 - 14.06.2024</duration><status>Završio</status><financ_value>129.232,20 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, Fizika, </scie_field_hr><scie_field_en>Biology, Physics, </scie_field_en><institution_hr><![CDATA[Institut za oceanografiju i ribarstvo]]></institution_hr><institution_en><![CDATA[Institute of Oceanography and Fisheries]]></institution_en><team_members_id>27304, 3007, 6195, 6245, 6846, 23416, 23420, 2983, </team_members_id><team_members_names><![CDATA[Jelena  Nejašmić, Gordana Beg Paklar, Marija Despalatović, Ivan Cvitković, Boris Antolić, Ante Zunec, Petra Lučić, Tomislav Džoić, ]]></team_members_names><keywords_hr><![CDATA[strane vrste, biološka invazija, Jadransko more, makroalge, beskralješnjaci, bentos, NIS]]></keywords_hr><keywords_en><![CDATA[alien species, biological invasion, Adriatic Sea, macroalgae, invertebrates, benthos, NIS]]></keywords_en><summary_hr><![CDATA[U hrvatskom podmorju ne postoje područja infralitoralnog čvrstog dna bez prisutnosti bNIS vrsta (benthic Non-Indigenous Species). Dostupni podaci ne prikazuju ni približno stanje vezano za brojnost, točnu identifikaciju i rasprostranjenost, a posebno utjecaj te unos i širenje. Projekt ima za cilj utvrditi popis i rasprostranjenost bNIS vrsta (makroalge i beskralješnjaci). To će se obaviti kroz taksonomsku, morfometrijsku i molekularnu reviziju povijesnih nalaza te prikupljanje novih informacija posebno na hot-spot područjima (jug Hrvatske, Kaštelanski zaljev, uzgajališta tuna), ali i vanjskim otocima, sjevernom Jadranu te koćarskim dnima. Prvi će se put za Hrvatsku sustavno istraživati fauna alohtonih mnogočetinaša. Praćenje bNIS vrsta ostvarit će se i aktivnim uključivanjem građanske znanosti. Kvantificirat ćemo utjecaj najinvazivnijih vrsta, primarno algi Womersleyella setacea i Acrothamnion preissii i Caulerpa cylindracea. Istražit će se biologija i ekologija, prvenstveno reproduktivni ciklusi i ekološke valencije s obzirom na osnovne ekološke čimbenike. Istražit će se odnosi sa zavičajnim herbivornim/predatornim vrstama, npr. sakoglosnih puževa i algi roda Caulerpa. Podaci o biologiji će, uz združeni ROMS-Ichthyop modelarski sustav, pomoći u razumijevanju njihovog širenja Jadranom. Ono se, pretpostavljamo, značajno događa morskim strujama pri čemu uzgajališta tuna, kao stepping-stone element, imaju ključnu ulogu. Istraživanjem obraštajne zajednice trupa transportnih brodova utvrdit će se značaj ovog vektora na unos i širenje bNIS vrsta. Obraštaj je često spominjan ali iznimno neistražen vektor širenja, te bi rezultati projekta mogli utjecati na globalno razumijevanje i upravljanje obraštajem trupa kao načinom širenja bNIS vrsta. Projekt će značajno povećati svijest javnosti o problemu stranih vrsta u morskom ekosustavu. Dobiveni podaci poslužit će kao osnova za provedbu EU smjernica i strategija, ali i kao važna osnova za buduće projekte vezane uz bNIS vrste.]]></summary_hr><summary_en><![CDATA[Finding an infralittoral hard bottom area within the Croatian part of the Adriatic without bNIS (benthic Non-Indigenous Species) is nearly impossible. Published data do not represent reality in terms of the number of bNIS, taxonomic accuracy, spatial distribution, spreading mechanisms and impacts. The BenthicNIS project aims to compile an accurate checklist of bNIS (macroalgae and invertebrates) and provide data on distribution. That will be done through taxonomic (morphometric and molecular) revision of historical and new findings particularly in hot-spot areas (South Croatia, Kaštela Bay, tuna fish farms), outer islands, North Adriatic and trawling bottoms.Our research will also include polychaetes, a neglected group in the East Adriatic. Extensive bNIS survey will be also achieved through active involvement of citizen scientists. The project will assess the impact level of the most invasive bNIS, particularly of Caulerpa cylindracea, Womersleyella setacea and Acrothamnion preissii.We will explore the biological and ecological features of bNIS, especially their reproductive cycles and ecological valences as well as interactions with native predators/herbivorous species, e.g. native sacoglossan and Caulerpa species. The information on biology together with coupled ROMS-Ichthyop modeling system will help us to demonstrate the role of ocean circulation and tuna fish farms (as a stepping stone element) in the bNIS spreading. Through the study of the commercial ship hull fouling, the importance of fouling as a vector for the primary introduction and secondary spread will be determined. Ship hull fouling was highly cited but rarely investigated vector and therefore our results might affect the global understanding and management of hull fouling.The Project will increase public awareness of the issue of biological invasion. Provided data will serve for the implementation of EU directives and strategies and as an important basis for future projects on bNIS.]]></summary_en></project><project>
<id>9153</id><title_hr><![CDATA[ZBRINJAVANJE PROČIŠĆENIH ZAULJENIH OTPADNIH VODA I MULJA S UPOV-A U OPEKARSKOJ INDUSTRIJI – PROIZVODNJA NOVOG OPEKARSKOG PROIZVODA U OKVIRU KRUŽNE EKONOMIJE]]></title_hr><title_en><![CDATA[USE OF TREATED OILY WASTEWATER AND SEWAGE SLUDGE IN BRICK INDUSTRY – PRODUCTION OF INNOVATIVE BRICK PRODUCTS IN THE SCOPE OF CIRCULAR ECONOMY]]></title_en><user_id>5991</user_id><user_firstLast_name>Dražen Vouk</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-1169</code><acronim><![CDATA[BRAVOBRICK]]></acronim><duration>01.12.2019 - 15.02.2024</duration><status>Završio</status><financ_value>195.786,05 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Građevinarstvo, Kemijsko inženjerstvo, Temeljne tehničke znanosti, Interdisciplinarne tehničke znanosti, </scie_field_hr><scie_field_en>Civil engineering, Chemical engineering, Basic engineering sciences, Interdisciplinary technological sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Građevinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Civil Engineering]]></institution_en><team_members_id>22647, 3406, 26308, 26309, 23275, 4065, 17785, 7020, 27353, 864937, </team_members_id><team_members_names><![CDATA[Ivan Halkijević, Nina Štirmer, Anđelina Bubalo, Morana Drušković, Karlo Nađ, Mario  Šiljeg, Domagoj Nakić, Christopher Cheeseman, Robert Kollar, Hana Posavčić, ]]></team_members_names><keywords_hr><![CDATA[zauljene otpadne vode,mulj,UPOV,elektrokemijski procesi,termička obrada,opeka,inovativni materijali,kružna ekonomija]]></keywords_hr><keywords_en><![CDATA[oily wastewater,sewage sludge,WWTP,electrochemical processes,thermal treatment,brick,innovative materials,circular economy]]></keywords_en><summary_hr><![CDATA[Konvencionalni postupci pročišćavanja zauljenih otpadnih voda su skupi pa se javlja potreba za razvojem novih tehnologija s nižim troškovima i mogućnošću materijalne oporabe pročišćene vode. Pročišćavanjem otpadnih voda, općenito, generira se nova vrsta otpada - mulj. S naglim porastom izgradnje UPOV-a problem zbrinjavanja mulja dobiva na težini. Mogućnost materijalne oporabe mulja ovisi o njegovu sastavu pa istraživanja s muljevima čiji se sastav razlikuje od onih generiranih na području Hrvatske treba uzeti s oprezom. Materijalnom oporabom mulja u građevinskoj industriji (proizvodnji opeke) mulj zamjenjuje dio prirodnog resursa (gline ili pijeska), čime se smanjuju pritisci na okoliš.Cilj istraživanja je pročistiti zauljene otpadne vode primjenom hibridnog elektrokemijskog procesa do kakvoće da se mogu učinkovito koristiti kao tehnološke vode u proizvodnji opeke te na temelju ispitivanja tehnoloških parametara optimizirati proces i minimizirati operativne troškove. Korištenje pročišćene vode, ulazi u okvire kružne ekonomije s mogućnošću dobivanja jeftinijih opeka, konkurentnijih na tržištu. Ispitat će se mogućnost korištenja mulja s UPOV-a (termički obrađenog) u opekarskoj industriji, a poseban doprinos bit će ispitivanje učinkovitosti sušenja mulja mikrovalovima. Neovisno o rezultatima na opeki, ovaj dio istraživanja primjenjiv je i šire, prvenstveno u obradi mulja s ciljem dobivanja što manjih količina higijeniziranog mulja. Postavit će se metodologija procjene tehničko-ekoloških utjecaja mulja i pepela iz mulja u proizvodnji opeke i definirati utjecaj kemijskog sastava i mikrostrukture mulja i pepela na svojstva gotovih proizvoda. Ispitivanjem izluživanja odredit će se njihova prikladnost za korištenje u okolišu.Rezultati istraživanja od interesa su za područje vodnog gospodarstva s ciljem zbrinjavanja zauljenih otpadnih voda i mulja s UPOV-a i za industriju proizvodnje građevnih materijala s ciljem smanjenja korištenja sirovina iz prirode, ali i emisija CO2.]]></summary_hr><summary_en><![CDATA[Conventional oily wastewater treatment is expensive so there is a need for new cheaper technologies and the possibility of material recovery of treated water. Wastewater treatment in general generates new waste - sludge. With the increase in the construction of WWTPs, this problem is even more important. The potential for material recovery of the sludge depends to a great extent on its composition, so results with sludge which composition differs from those generated in Croatia should be taken with caution. The material recovery of sludge in the construction industry (brick production) replaces part of the natural resources (clay or sand), thereby reducing environmental stresses.The aim of this research is to treat the oily wastewater using a hybrid electrochemical process, so it can be applied as technological water in brick industry, and to optimize the process and minimize operating costs by examining technological parameters. The use of treated water contributes to the circular economy with the possibility of obtaining cheaper, more competitive bricks. The possibility of using sludge in the brick industry will be investigated, and a special contribution will be to examine the efficiency of sludge drying by microwaves. Regardless of the results on the bricks, this part of the research is applicable even more widely, primarily in sludge treatment to obtain as little as possible of hygienic sludge. The methodology for assessing technical and ecological impacts of sludge/ash in brick production will be established and the influence of chemical composition and microstructure of sludge/ash on the properties of final products will be defined. Testing the leaching will determine its suitability for use in the environment.The research results are of interest to the water management sector with the aim of disposing of oily wastewater and sludge and for the construction materials industry with the aim of reducing the use of raw materials, but also reducing CO2 emissions.]]></summary_en></project><project>
<id>9157</id><title_hr><![CDATA[Fazni prijelazi u sustavima s jakim elektronskim korelacijama inducirani tlakom i temperaturom ]]></title_hr><title_en><![CDATA[Pressure- and Temperature-drive Phase transitions in Strongly Correlated Electron Systems]]></title_en><user_id>25109</user_id><user_firstLast_name>Yuki Utsumi Boucher</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2019-04</proposal_call><code>UIP-2019-04-2154</code><acronim><![CDATA[PaT PiSCES]]></acronim><duration>01.01.2020 - 30.06.2025</duration><status>Završio</status><financ_value>262.951,76 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, Interdisciplinarne prirodne znanosti, </scie_field_hr><scie_field_en>Physics, Interdisciplinary natural sciences, </scie_field_en><institution_hr><![CDATA[Institut za fiziku]]></institution_hr><institution_en><![CDATA[Institute of Physics in Zagreb]]></institution_en><team_members_id>28808, 865280, </team_members_id><team_members_names><![CDATA[Naveen Singh  Dhami, Seyed Ashkan Moghadam Ziabari, ]]></team_members_names><keywords_hr><![CDATA[visoki tlak, jake elektronske korelacije, supravodljivost, transport, spektroskopija]]></keywords_hr><keywords_en><![CDATA[high pressure, strong electron correlations, superconductivity, transport, spectroscopy]]></keywords_en><summary_hr><![CDATA[Jake elektronske korelacije su jedno od središnjih pitanja u fizici kondenzirane materije i uzrokuju razne elektronske fenomene, kao što su Mottov prijelaz, nekonvencionalna supravodljivost, uređivanje naboja / spina, magnetski fazni prijelazi i pojava teških fermiona. U takvim sustavima, složeni fenomeni proizlaze iz povezivanja deformacija kristalne rešetke i orbitalnih, nabojnih i spinskih stupnjeva slobode. Da bi se razumio mehanizam faznih prijelaza i da bi se kontrolirala svojstva sustava, potrebno proučavanju pristupiti komplementarnim eksperimentalnim tehnikama koje proučavaju kako atomske tako i elektronske strukture. Tlak je direktna i čista metoda kojom se mogu kontrolirati fizikalna svojstava materijala bez induciranja nehomogenosti ili nereda. Nedavni napredak u tehnikama postizanja visokih tlakova rezultirao je otkrićem anomalnih pojava koje se javljaju u prisustvu jakih korelacija, proširenju klase supravodljivih materijala, te konačno u rekordnoj temperaturi supravodljivog prijelaza od 200 K u sumporovodiku. Glavni cilj projekta je razviti dijamantnu ćeliju za postizanje visokih tlakova za mjerenje transportnih svojstava na Institutu za fiziku, te primijeniti tu tehniku pri istraživanju novih pojava u jako koreliranim sustavima u ekstremnim uvjetima. Napose su u istraživačkom fokusu projekta fazni prijelazi inducirani tlakom i temperaturom u jako koreliranim elektronskim sustavima, kao što su sulfidi prijelaznih metala i spojevi rijetkih zemalja. Kombinacija strukturnih i spektroskopskih istraživanja, kao i istraživanja transportnih svojstava, pružit će cjelovitu sliku faznih prijelaza u tim sustavima.]]></summary_hr><summary_en><![CDATA[Strong electron correlations have been a central issue in condensed matter physics and been the cause of various electronic phenomena, such as the Mott transition, unconventional superconductivity, charge/spin ordering, magnetic phase transition, and heavy fermion behavior. In such systems, complex phenomena are arising from coupled lattice, orbital, charge and spin degrees of freedom. To understand the mechanism of phase transitions and to control the properties, it is necessary to tackle the problems with complementary experimental techniques studying both atomic and electronic structures. Pressure is a clean method to control physical properties of material without inducing inhomogeneity or disorder. Recent progress in high-pressure techniques resulted in discoveries of anomalous phenomena emerging under pressure in a presence of strong correlations, extension of superconducting class of materials and finally in the record-breaking highest superconducting transition temperature of 200 K in sulfur hydrides. The main objective of the project is to develop high-pressure diamond anvil cell for transport measurement at the Institute of Physics, and apply the technique to explore novel phenomena on strongly correlated systems under extreme conditions. Especially, the pressure and temperature induced phase transitions in the strongly correlated electron systems, such as transition metal sulfides and rare-earth compounds, are the main research targets of the project. Combination of the structural and spectroscopic studies, as well as transport properties, will provide a whole picture of phase transitions. ]]></summary_en></project><project>
<id>9162</id><title_hr><![CDATA[Simulator poremećaja u elektroenergetskom sustavu i kalibrator nesinusnih napona i struja]]></title_hr><title_en><![CDATA[Power system disturbance simulator and nonsinusoidal voltages and currents calibrator]]></title_en><user_id>3230</user_id><user_firstLast_name>Goran Petrović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-7292</code><acronim><![CDATA[SIMPES]]></acronim><duration>01.02.2020 - 31.01.2024</duration><status>Završio</status><financ_value>108.715,41 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Fakultet elektrotehnike, strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Electrical Engineering, Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>4309, 23434, 3516, 12749, 26646, 5372, 142, 5389, 5507, 5483, 26563, 22472, 26649, 866625, </team_members_id><team_members_names><![CDATA[Marin Despalatović, Elis Sutlović, Tonko Garma, Goran Majić, Marin Mandić, Roman Malarić, Marko Jurcevic, Petar Mostarac, Hrvoje Hegeduš, Kruno Miličević, Dragan Vulin, Ivan Biondic, Petar Sarajcev, Antonio Šunjerga, ]]></team_members_names><keywords_hr><![CDATA[Elektroenergetski sustav, Izmjenjivač, Simulator, Kalibrator, Harmonici, Sinkrofazori, PMU]]></keywords_hr><keywords_en><![CDATA[Electric Power System, Inverter, Simulator, Calibrator, Harmonics, Synchronized phasor, PMU]]></keywords_en><summary_hr><![CDATA[Glavna smjernica razvoja prijenosnog i distribucijskog sustava u Republici Hrvatskoj ali i drugim zemljama, podrazumijeva implementaciju koncepta napredne mreže. Ključna karika u tom konceptu je predodžba električnih veličina sinkroniziranim fazorima.  Uspostava satelitske mreže omogućila je sinkroniziranje mjernih uređaja, tzv. Phasor Measurement Unit (PMU). Mjerenje u ustaljenim stanjima i prijenos podataka prema upravljačkom centru dobro je definirano odgovarajućim IEEE i IEC normama. Zbog velikih nelinearnih trošila te sve veće penetracije obnovljivih izvora energije česta su odstupanja od stacionarnih stanja. U stanjima poremećaja, poglavito u brzim prijelaznim pojavama, mjerenje sinkrofazora nije precizno definirano normama pa je to aktualno područje znanstvenog istraživanja. Kako bi se različiti istraživani i implementirani algoritmi mogli testirati, neophodno je posjedovati odgovarajući uređaj za testiranje koji može generirati uobičajene poremećaje u elektroenergetskom sustavu.Glavni cilj ovog projekta je projektiranje i izrada prototipa simulatora poremećaja koji generira odgovarajuće napone i struje. Drugi cilj je projektiranje i izrada prototipa kalibratora nesinusnih trofaznih napona i struja, te izrada preciznih pretvornika struje i napona. Također će se istraživati i različite primjene podataka dobivenih sinkrofazorima. Glavne značajke predviđene metodologije su matematičko modeliranje spomenutih prototipova u Matlab i PLECS softveru. Istraženi algoritmi upravljanja zatim će se implementirati na FPGA hardverskoj platformi. Projektni tim čine znanstvenici s tri sveučilišta u Hrvatskoj Očekivani učinak istraživanja očituje se u doprinosu afirmaciji modernog načina nadzora i upravljanja elektroenergetskog sustava, baziranog na mjerenju sinkrofazora. Poseban doprinos očekuje se u razumijevanju i testiranju koncepta sinkroniziranih fazora u nestacionarnim uvjetima.]]></summary_hr><summary_en><![CDATA[The main guideline for the development of the transmission and distribution system in the Republic of Croatia and other countries implies the implementation of the concept of the smart grid. The key link in the concept is the representation of electrical quantities with synchro-phasors. The establishment of the satellite network enabled the synchronization of measuring devices, Phasor Measurement Units (PMU). Measurement in standby states and data transfer to the control center is well defined with the corresponding IEEE and IEC standards.Because of large nonlinear loads and increasing presence of the renewable energy sources, there are frequent deviations from stationary conditions. During the disturbances, especially in case of fast transient phenomena, synchro-phase measurement is not precisely defined by standards, making it is the active area of scientific research. In order to test differently investigated and implemented algorithms, it is necessary to have a suitable testing device that can generate common electrical system disturbances.The main objective of this project is to design and develop a prototype of a simulator that generates appropriate voltage and current. Another aim is to design and manufacture non-sinusoidal three-phase voltage and current calibrators prototype and to produce precise current and voltage transducers. Different applications of data obtained from synchro-phasors will also be explored. The main features of the foreseen methodology are mathematical modeling of the mentioned prototypes. The explored control algorithms will then be implemented on the FPGA hardware platform. The project team consists of scientists from three universities in Croatia.The expected impact of the research is reflected in contributing to the affirmation of a modern way of controlling and managing the power system, based on PMU. A special contribution is expected in understanding and testing the concept of synchro-phasors in non-stationary conditions.]]></summary_en></project><project>
<id>9163</id><title_hr><![CDATA[Motorički učinci klostridijskih neurotoksina u središnjem živčanom sustavu]]></title_hr><title_en><![CDATA[Motor effects of clostridial neurotoxins in central nervous system]]></title_en><user_id>4022</user_id><user_firstLast_name>Ivica Matak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2019-04</proposal_call><code>UIP-2019-04-8277</code><acronim><![CDATA[MEFCLO]]></acronim><duration>01.01.2020 - 31.12.2024</duration><status>Završio</status><financ_value>199.084,21 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>3901, 855903, 865240, 865164, </team_members_id><team_members_names><![CDATA[Višnja Drinovac, Petra Šoštarić, Dalia Vađunec Vađunec, Patrik Meglić, ]]></team_members_names><keywords_hr><![CDATA[klostridijski neurotoksini, neurološki poremećaji pokreta, mišićna hiperaktivnost, središnje motorne regije, središnje djelovanje]]></keywords_hr><keywords_en><![CDATA[clostridial neurotoxins, neurological movement disorders, muscle hyperactivity, central motor regions, central action]]></keywords_en><summary_hr><![CDATA[Klostridijski neurotoksini poput tetanus toksina (TeNT) i botulinum toksina tipa A (BoNT/A) su jedni od najpotentnijih bioloških toksina, te uzročnici simptoma tetanusa i botulizma. Terapijski, male doze BoNT/A se koriste za liječenje hiperkinetskih poremećaja pokreta i spasticiteta, međutim, naša preliminarna istraživanja pokazuju da bi se važan dio njegova utjecaja na abnormalno povećan mišićni tonus moglo odvijati u središnjem živčanom sustavu. Predloženi projekt obuhvaća karakterizaciju novih pretkliničkih modela hiperkinetskih poremećaja pokreta, te karakterizacije učinka BoNT/A. Cilj istraživanja je pomoću vrlo malih doza i volumena TeNT i BoNT/A primijenjenih periferno u mišić ili u određene regije središnjeg živčanog sustava izazvati disbalans u ekscitacijskoj i inhibicijskoj neurotransmisiji motornih regija, koje će oponašati hiperkineziju i hipertoniju prisutnu kod spasticiteta ili distonija. U životinja s hiperkinezijom, karakterizirat će se učinci botulinum toksina u ekstrafuzalnim i intrafuzalnim motornim vlaknima, te centralnim neuronima ventralnog roga i moždanog debla. Središnje djelovanje BoNT/A bit će okarakterizirano pomoću intratekalno primijenjenog  BoNT/A-neutralizirajućeg antitoksina. U istraživanjima će se koristiti bihevioralne 2D i 3D videoanalize hoda u normalnih i hiperkinetičkih životinja tretiranih i ne-tretiranih s BoNT/A. Također će se koristiti i motorički testovi održavanja ravnoteže, umora, te otpora zglobova na pasivno savijanje. Učinci toksina će biti okarakterizirani elektromiografskim mjerenjma spinalnih refleksa te analizom ekspresije neurotransmitora i proteinskih markera vezanih uz motoričku transmisiju. Očekivani znanstveni rezultati biti će zanimljivi u polju neurologije kao iskorak u pretkliničkom ispitivanju novih terapijskih pristupa u liječenju poremećaja pokreta te zbog temeljnih saznanja vezanih uz plastičnost senzornomotoričkog sustava i mehanizama utjecaja klostridijskih neurotoksina na središnji živčani sustav.]]></summary_hr><summary_en><![CDATA[Clostridial neurotoxins such as tetanus toxins (TeNT) and botulinum toxins of type A (BoNT /A) are one of the most potent biological toxins, and causative agents of tetanus and botulism. Therapeutically, low doses of BoNT /A are used to treat hyperkinetic movement disorders and spasticity.  Our preliminary studies indicate that an important part of its effect on abnormally increased muscle tone may occur in the central nervous system. Proposed project involves characterization of new preclinical models of hyperkinetic motion disorders, and characterization of the central effects of BoNT/A. The aim of the study is to induce the imbalance of excitatory and inhibitory neurotransmission of motor regions with very small doses and volumes of TeNT and BoNT/A applied into the peripheral muscle, or into certain regions of the central nervous system. This will imitate hyperkinesia and hypertonia present in spasticity or dystonia. In animals with hyperkinesia, the effects of botulinum toxins will be characterized in extrafusal and intrafusal motor fibers, as well as central neurons of the ventral horn and brain stem. Central activity of BoNT/A will be characterized by intrathecally applied BoNT /A-neutralizing anti-toxin.  Behavioral 2D and 3D video analysis of walking in normal and hyperkinetic animals, as well as motor tests of balance, fatigue, and the joint resistance of joints to passive movement will be used to study the BoNT/A effects. The toxin effects will also be characterized by electromyography of spinal reflexes, and analysis of expression of neurotransmitter and proteins involved in motor neurotransmission. In the field of neurology and neuroscience, the expected scientific results will be a step forward in the preclinical study of new therapeutic approaches to the treatment of motion disorders, the basic knowledge about the plasticity of the motor system, and the mechanism of the influence of clostridial neurotoxins on the central nervous system.]]></summary_en></project><project>
<id>9164</id><title_hr><![CDATA[Razvoj i naslijeđe viteških redova u Hrvatskoj]]></title_hr><title_en><![CDATA[Development and Heritage of the Military Orders in Croatia]]></title_en><user_id>25921</user_id><user_firstLast_name>Juraj Belaj</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-5513</code><acronim><![CDATA[milOrd]]></acronim><duration>01.01.2020 - 30.06.2024</duration><status>Završio</status><financ_value>78.739,13 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Arheologija, Povijest, Povijest umjetnosti, </scie_field_hr><scie_field_en>Archeology, History, Art history, </scie_field_en><institution_hr><![CDATA[Institut za arheologiju]]></institution_hr><institution_en><![CDATA[Institute of Archaeology in Zagreb]]></institution_en><team_members_id>11254, 11265, 8131, 12982, 633, 22663, 567, 22536, 26249, 26613, 26066, 27357, 26610, 23460, 29078, </team_members_id><team_members_names><![CDATA[Tatjana Tkalčec, Siniša Krznar, Zsolt  Hunyadi, Renata Šoštarić, Marija Karbić, Marija Mihaljević, Željka Bedić, Filomena Sirovica, Dinko Tresić Pavičić, Ratko Ivanušec, Iva Papić, Marko Meštrov, Sebastijan Stingl, Marijana Belaj, Tea Kokotović, ]]></team_members_names><keywords_hr><![CDATA[Viteški redovi, templari, ivanovci, baština, sakralna arhitektura, fortifikacijska arhitektura, grobni nalazi, antropološke analize	]]></keywords_hr><keywords_en><![CDATA[Military orders, Templars, Hospitallers, heritage, sacral architecture, fortification architecture, grave finds, anthropological analysis]]></keywords_en><summary_hr><![CDATA[Predloženim se projektom namjerava interdisciplinarno istražiti templare i ivanovce u Hrvatskoj, prateći njihov razvoj i mijene njihovih lokaliteta. Proučavat će se transformacije različitih pokretnih i nepokretnih nalaza i uzoraka na sljedećim lokalitetima: Gora, Ivanec, Sv. Martin na Prozorju, Gradišče kod Margečana, Pakrac, Račeša i Vrana. U obzor istraživanja ući će i ostali sačuvani objekti viteških redova te muzeji i arhivi. Ciljevi se namjeravaju postići usporednim istraživanjima i analizama na više razina: povijesnih i povijesno-umjetničkih izvora, arheoloških nalaza, uzoraka tla i ljudskih kosturnih ostataka. Odabrani uzorci bit će podvrgnuti radiokarbonskoj analizi te analizi stabilnih izotopa dušika i ugljika. Temeljna pitanja na koja će se komparativnom metodom tražiti odgovori su: mogu li se na temelju povijesnih, arheoloških, biološko-antropoloških i arheobotaničkih podataka, kao i na ostacima graditeljske i umjetničke građe, ustanoviti inovacije za koje se pretpostavlja da su ih viteški redovi donijeli u promatrane krajeve te kako su time utjecali na kvalitetu života svojih podložnika? Tijekom predloženog projekta planira se zapošljavanje doktoranda/ice čija će tema biti usko povezana s temom projekta. Diseminacija znanja planirana je tijekom čitavog trajanja predloženog projekta putem javnih predavanja, izlaganja na kongresima, objavljivanja radova u znanstvenim časopisima, organiziranja međunarodne konferencije, postavljanja izložbe te objavljivanja e-monografije s rezultatima projekta. Informacije o poduzetim aktivnostima bit će kontinuirano objavljivane na mrežnim stranicama projekta. Predloženim projektom produbit će se dosadašnje spoznaje te steći nove o slabo istraženim viteškim redovima na ovome prostoru: povećat će se uvid u količinu i kvalitativne značajke njihovih materijalnih tragova, u njihov utjecaj na lokalne zajednice i lokalnu kulturu, u mijene viteških redova i njihovih lokaliteta te će se jasnije moći definirati njihova ostavština.]]></summary_hr><summary_en><![CDATA[The goal of the proposed project is to conduct an interdisciplinary research of the military orders in Croatia by observing their development and changes on their sites. Transformations of various finds and samples will be studied on the following sites: Gora, Ivanec, St Martin-Prozorje, Gradišče-Margečan, Pakrac, Račeša and Vrana. Other preserved structures of the military orders will also be included in the research as well as museums and archives. The plan is to reach the goals by parallel research and analyses on several levels: of archaeological, historical and art historical sources, samples of soil and human skeletal remains. Selected samples will be subjected to radiocarbon analysis and stable carbon and nitrogen isotope analysis. We will try to answer the following question by means of comparative method: Can the innovations which are presumed to be brought to the observed areas by the military orders and their influence on the life of their subjects be identified based on historical, archaeological, biological anthropological and archaeobotanical data and the remains of architecture and artwork? In the course of the proposed project, employment of a doctoral student is planned, whose theme will be closely related to the theme of the project. Dissemination of knowledge is planned via public lectures, presentations at conferences, papers in scientific journals, organising an international conference, mounting an exhibition and publishing an e-monograph with project results. Information on the conducted activities will be continuously posted on the website. The proposed project will deepen the existing and provide new insights on the scarcely researched military orders in this area: it will expand our knowledge about the quantity and qualitative features of their material remains, their influence on local communities and local culture and about the transformations of military orders and their sites, thereby enabling us to define their heritage more clearly.]]></summary_en></project><project>
<id>9166</id><title_hr><![CDATA[ISTRAŽIVAČKI NOVINARSKI LABORATORIJ: Vjerodostojnost medija kroz kulturu eksperimenta i inovacije u redakcijama]]></title_hr><title_en><![CDATA[JOURNALISM RESEARCH LAB: Innovative Storytelling  Practices To Engage New Audiences]]></title_en><user_id>27365</user_id><user_firstLast_name>Tena Perišin</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-6331</code><acronim><![CDATA[JOURLAB]]></acronim><duration>03.01.2020 - 02.01.2024</duration><status>Završio</status><financ_value>69.688,83 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Informacijske znanosti, </scie_field_hr><scie_field_en>Information sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet političkih znanosti]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Political Science]]></institution_en><team_members_id>13153, 6659, 27370, 27366, 865468, 864828, </team_members_id><team_members_names><![CDATA[Petra Kovačević, Andrija  Henjak, Stela Lechpammer, Igor Kanižaj, Nensi Blažević, Dejan Oblak, ]]></team_members_names><keywords_hr><![CDATA[novinarstvo, vijesti, vjerodostojnost, inovacije, digitalna tehnologija, publike, novinarske prakse, redakcijske prakse]]></keywords_hr><keywords_en><![CDATA[journalism, news, credibility, innovation, digital technology, audiences, journalism practices, newsroom practices]]></keywords_en><summary_hr><![CDATA[Cilj projekta je istraživanje percepcije medija i informativnih sadržaja koji mediji u Hrvatskoj nude i istraživanja medijskih oblika kojima se može povećati kvaliteta informativnih sadržaja, interes javnosti te vjerodostojnost medija. Cilj projekta je i osmišljavanje i testiranje novih medijskih informativnih oblika, te uspostavljanje novinarskog laboratorija na Fakultetu političkih znanosti Sveučilišta u Zagrebu, u kojem bi se ovi sadržaji proizvodili i testirali prema uzoru na primjere dobre prakse na vrhunskim sveučilištima u SAD-u i Europi. U sklopu projekta provest će se istraživanje medijskih sadržaja kako bi se utvrdio njegov prevladavajući karakter s obzirom na sadržaj i formu. Provest će se i istraživanje percepcije medijskih sadržaja i oblika od strane medijskih publika, kako bi se utvrdilo kako one doživljavaju medijski sadržaj i formu s obzirom na kvalitetu informacija koje nudi, interes koji budi kod javnosti te vjerodostojnost. S istim ciljem će se provesti i istraživanje na praktičarima unutar medija kako bi se utvrdilo način na koji medijski sadržaj vide akteri koji ga proizvode i koliko se njihova percepcija razlikuje od percepcije medijskih publika. U sklopu projekta provest će se mapiranje inovativnih novinarskih praksi u međunarodnom kontekstu kako bi se identificirali primjeri dobrih praksi i pronašli obrasci koji će se koristiti u izradi inovativnih medijskih sadržaja, koji će se potom testirati na fokus skupinama. U tu svrhu projekt će razvijati inovativne oblike digitalnog novinarstva, načina na koji novinari stvaraju i prenose informacije, proizvode multimedijske audiovizualne priloge, te oblikuju nove načine prezentacije sadržaja koristeći digitalne alate. Konačno, ti oblici novinarskog izričaja izrađeni uz inovativne digitalne alate testirat će se u fokus grupama s predstavnicima medijskih publika i novinarima iz prakse.  ]]></summary_hr><summary_en><![CDATA[The project objective is the research of the perception of media informative content in Croatia, and research of media form which can be used in order to increase quality of informative content, public interest in them and media credibility. The project objective is creation and testing of the new media informative forms and establishment of the news lab at the Faculty of Political Science of Zagreb University, where this content would be produced and tested in accordance with good practices developed at universities in USA and Europe.The project will include research of media content in order to establish what form of content and form dominates. Perception of media content by the media public will also be performed in order to establish how media public see media content with respect to quality of information it offers, public interest it provokes and credibility. With the same objective the project will research practitioners within media in order to establish how media content is seen by the actors that produce it and how is their perception different from the perception of media publicThe project will map innovative journalist practices in the international context in order to identify the examples of good practices and find forms that will be used in the production of innovative media content, which will be tested on focus groups. To that end, the project will develop innovative forms of digital journalism, ways journalists use and transmit information, produce audiovisual content and shape new forms of content presentation using digital tools. Finally, these forms of journalistic expression created through innovative tools will be tested in focus groups and with practicing journalists.]]></summary_en></project><project>
<id>9167</id><title_hr><![CDATA[NGS analiza transkriptoma MAIT i ydT limfocita: fenotip, funkcija i raznolikost TCR klonova u podlozi razvoja vulgarne psorijaze]]></title_hr><title_en><![CDATA[NGS analysis of MAIT and ydT cell transcriptome: phenotype, function and TCR repertoire in the aetiology of Psoriasis vulgaris]]></title_en><user_id>4749</user_id><user_firstLast_name>Stana Tokić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2019-04</proposal_call><code>UIP-2019-04-3494</code><acronim><![CDATA[NGSmyPHENOTIP]]></acronim><duration>01.02.2020 - 31.07.2025</duration><status>Završio</status><financ_value>265.432,34 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Kliničke medicinske znanosti, Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Clinical sciences, Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Medicinski fakultet Osijek]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Medicine]]></institution_en><team_members_id>4439, 1146, 27010, 13293, 855348, 864821, 488, 869838, </team_members_id><team_members_names><![CDATA[Barbara Viljetić, Teuta Opačak-Bernardi, Vera Plužarić, Maja Tolušić Levak, Marija Šola, Maja Jirouš, Martina Mihalj, Rebeka Monika Oklopčić, ]]></team_members_names><keywords_hr><![CDATA[TCR repertoar, MAIT, gamma delta T limfociti, psorijaza, NGS, fenotip]]></keywords_hr><keywords_en><![CDATA[TCR repertoire, MAIT, gamma delta T lymphocytes, psoriasis, phenotype]]></keywords_en><summary_hr><![CDATA[Vulgarna psorijaza je kronična upalna dermatoza složene, dijelom genetičke etiologije, posredovana djelovanjem različitih imunosnih stanica. Važnu ulogu imaju T limfocitne loze koje trajno naseljavaju kožne lezije oboljelih, te uzrokuju kožne promjene otpuštanjem upalnih citokina IL-17, INF-y i TNF-a, ključnih medijatora upalnih procesa u psorijazi. Značajan udio IL-17+ infiltrirajućih T limfocitnih populacija čine nekonvencionalni efektori prirođenog imunološkog odgovora, ydT-limfociti i novootkrivene CD3+MR1+TCR-Va7.2+PLZF+RORyt+ MAIT stanice, koje izražavaju ograničeni TCR repertoar i prepoznaju kožnom okolišu svojstvene, mikrobne antigene u kompleksu s MR1, odnosno CD1c molekulama. Novije studije ukazuju na značajnu heterogenost fenotipa i funkcije MAIT i ydT stanica, koje pokazuju sposobnost prilagodbe imunološkog odgovora, pri čemu raznolikost TCR repertoara, omogućava fino podešavanje afiniteta MAIT i ydT stanica na različite antigene. Unatoč razumijevanju fenotipa i funkcije, potencijalno važna uloga MAIT i ydT-stanica u pojavi, progresiji i ishodu psorijaze uglavnom je neistražena. Cilj ovoga projekta je ustanoviti frekvenciju i pojedinačni doprinos perifernih i tkivnih MAIT i ydT stanica u razvoju psorijaze i porastu serumske razine citokina i kemokina u oboljelih. U svrhu identifikacije potencijalnih terapeutskih meta, ispitati će se regulatorni mehanizmi u kontroli funkcije MAIT i ydT-stanica, mjerenjem genske ekspresije transkripcijskih čimbenika, citokinskih i kemokinskih receptora. Primjenom NGS tehnologije za analizu raznolikosti TCR repertoara, na uzorcima RNA iz sortiranih MAIT i ydT stanica nadamo se osigurati identifikaciju ekspandiranih, javnih TCR klonova i rizičnih genskih varijanti TRA, TRB, TRG i TRD lokusa koje sudjeluju u njihovom razvoju. Novo identificirane, rizične varijante TCR klonova mogu poslužiti za razvoj specifičnih terapeutskih pristupa u svrhu trajne kontrole patogenih MAIT i ydT limfocitnih vrsta u podlozi razvoja psorijaze. ]]></summary_hr><summary_en><![CDATA[Psoriasis vulgaris is a chronic, recurrent inflammatory dermatosis with complex, partially genetic aetiology, mediated by immune cells. T lymphocytes that reside within the skin of psoriatic patients, have been recognized as the important players involved in psoriatic plaque formation through release of IL-17, INF-y and TNF-a. A significant part of the IL-17+ skin infiltrating population comprises unconventional effectors of innate immune response, ydT lymphocytes and CD3+MR1+TCR-Va7.2+PLZF+RORyt+ MAIT cells, which exhibit limited TCR repertoire and recognize specific MHC-independent, non-peptide microbial antigens in complex with MR1 or CD1c molecules, respectively. Recent studies suggest a significant heterogeneity of MAIT and ydT cell phenotype, function and adaptive capability, whereby increased variety of TCR clonotypes, enables fine tuning of MAIT and ydT cell affinity for various antigens. Despite improved understanding of their phenotype and function, the role of MAIT and ydT cells in initiation, progression and outcome of psoriasis is still largely unknown. The goal of this project is to determine frequency and the individual contribution of peripheral and tissue MAIT and ydT cells in development of psoriasis, and the patient serum levels of inflammatory cytokines and chemokines. To identify new therapeutic targets, we will also investigate regulatory mechanisms underlying MAIT and ydT phenotype and function, by probing expression of specific transcription factors, cytokine and chemokine receptors. Using NGS technology for TCR repertoire analysis in RNA samples isolated from sorted MAIT and ydT cells, we hope to ensure the identification of potentially expanded, public TCR clones and risk variants of TRA, TRB, TRG and TRD loci involved in TCR development. Newly identified risk variants of TCR clonotypes can be used to develop targeted therapeutic approaches to permanently control pathogenic MAIT and ydT lymphocyte species in the aetiology of psoriasis.]]></summary_en></project><project>
<id>9172</id><title_hr><![CDATA[Prapovijesni lovci i sakupljači u Istri i obližnjim regijama: obrasci života tijekom kasnog pleistocena ]]></title_hr><title_en><![CDATA[Prehistoric hunter gatherers in Istria and adjacent regions: patterns of Late Pleistocene lifestyle and mobility ]]></title_en><user_id>2764</user_id><user_firstLast_name>Ivor Janković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-7821</code><acronim><![CDATA[PREHISTRIA]]></acronim><duration>15.02.2020 - 14.02.2024</duration><status>Završio</status><financ_value>79.633,55 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Arheologija, Etnologija i antropologija, </scie_field_hr><scie_field_en>Archeology, Ethnology and anthropology, </scie_field_en><institution_hr><![CDATA[Institut za antropologiju]]></institution_hr><institution_en><![CDATA[Institute for Anthropological Research]]></institution_en><team_members_id>3839, 2670, 2993, 2744, 4112, 21180, 6897, 12720, 4229, 23881, 26990, 19178, 19232, 27046, 864947, 19342, </team_members_id><team_members_names><![CDATA[James Ahern, Mario Novak, Barbara Cvitkušić, Siniša Radović, Sanjin Mihelić, Antonela Barbir, Darko Komšo, Zlatko Perhoč, Rory Becker, Emanuela Cristiani, Marco Peresani, Stefano Benazzi, Ron Pinhasi, Federica Fontana, Lia Vidas, Nikola Vukosavljević, ]]></team_members_names><keywords_hr><![CDATA[pleistocen, paleolitik,prapovijest, litička analiza, Istra]]></keywords_hr><keywords_en><![CDATA[Pleistocene, Palaeolithic, Prehisstory, Lithic analysis, Istria]]></keywords_en><summary_hr><![CDATA[Glavni ciljevi projekta Prapovijesni lovci i sakupljači u Istri i obližnjim regijama: obrasci života tijekom kasnog pleistocena (PREHISTRIA) su dobiti bolji i detaljniji uvid u aspekte ponašanja gornjopaleolitičkih stanovnika Istre; usporediti ove prilagodbe u vremenskim (kronološkim) i prostornim (geografskim) dimenzijama; diseminirati rezultate istraživanja i tako stvoriti dobru osnovu za daljnje komparativne studije gornjeg paleolitika u široj geografskoj regiji, te podići javnu svijest o važnosti lokalnog arheološkog naslijeđa, posebice gornjopaleolitičkih nalazišta u Istri. Navedene ciljeve postići ćemo putem interdisciplinarnih istraživanja i pristupa, uključujući: 1. arheološka istraživanja na dva nalazišta na kojima su pronađeni pokazatelji ljudskog prisustva u radoblju gornjeg paleolitika (Abri Kontija 002 i Ljubićeva pećina, oba u Istri), 2. detaljne analize arheoloških nalaza s navedenih, kao i još nekoliko nalazišta s prostora Istre (Romualdova Pećina, Pupićina peć i Šandalja II) i nalazišta s prostora Italije (Grotta del Broion, Riparo Broion, Grotta Paina, Grotta Fiumane, Grotta Rio Secco, Ponte di Pietra, Grotta Trene, and Riparo Tagliente), 3. Usporedbu s ranije obljavljenim resultatima analiza relevantnih lokaliteta u obližnjim prostorima (npr. Dalmacija, Bosna i Hercegovina i dr.), 4. kroz aktivni pristup promicanju spoznaja o važnosti arheološke građe i lokaliteta u javnosti.]]></summary_hr><summary_en><![CDATA[The main objectives of the proposed project are: to: 1.get a better and more detailed insight into behavioural aspects of the Upper Palaeolithic inhabitants of Istria; 2. to compare these aspects and adaptations in both temporal (chronological) and spatial (geographic) dimensions; 3. to disseminate results of the research and thus create a good basis for further comparative studies on the Upper Palaeolithic in a wider geographical region, and to raise public awareness of the importance of local archaeological heritage. We will address these aims through a combination of: 1. fieldwork at two sites that yielded evidence of human occupation during the Upper Palaeolithic (Abri Kontija 002, and Ljubićeva pećina in Istria), 2. detailed analysis of finds from the excavations, and from several additional sites in Istria (Romualdova pećina, Pupićina peć, and Šandalja II) and relevant sites in Italy (Grotta del Broion, Riparo Broion, Grotta Paina, Grotta Fiumane, Grotta Rio appropriate Upper Palaeolithic sites in adjacent regions (e.g. Bosnia and Herzegovina, Dalmatia etc.), and 4. through an active engagement with and dissemination of knowledge to public audiences. ]]></summary_en></project><project>
<id>9175</id><title_hr><![CDATA[Formuliranje inkapsuliranih sustava bioaktivnih sastojaka tradicionalnih biljnih vrsta: trave ive i dobričice namijenjenih razvoju inovativnih funkcionalnih prehrambenih proizvoda]]></title_hr><title_en><![CDATA[Formulating encapsulated systems of bioactive ingredients from traditional plants: mountain germander and ground ivy for the development of innovative functional food products]]></title_en><user_id>4544</user_id><user_firstLast_name>Draženka Komes</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-5879</code><acronim><![CDATA[FUNCBIOCAP]]></acronim><duration>01.03.2020 - 29.02.2024</duration><status>Završio</status><financ_value>131.229,68 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Prehrambena tehnologija, Poljoprivreda, Biotehnologija, Nutricionizam, </scie_field_hr><scie_field_en>Food technology, Agriculture, Biotechnology, Nutrition, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Food Technology and Biotechnology]]></institution_en><team_members_id>13101, 4425, 13238, 12445, 4438, 13247, 26476, 858412, 866623, </team_members_id><team_members_names><![CDATA[Ksenija Marković, Krunoslav Žižek, Vesna Benković, Sofia Ana Blažević, Aleksandra  Vojvodić Cebin, Anica Horvat Knežević, Danijela Šeremet, Ana Mandura, Katarina Sokač, ]]></team_members_names><keywords_hr><![CDATA[bioaktivni spojevi, dobričica, ekstrakcija, funkcionalni proizvodi, inkapsulacija, polifenoli, trava iva]]></keywords_hr><keywords_en><![CDATA[bioactive compounds, ground ivy, extraction, functional products, encapsulation, polyphenols, mountain germander]]></keywords_en><summary_hr><![CDATA[Sukladno povećanoj potražnji suvremenog potrošača za novim funkcionalnim prehrambenim proizvodima, ciljevi ovog projekta su: i) definiranje najučinkovitijih postupaka ekstrakcije tradicionalnih, a nedovoljno istraženih, biljnih vrsta: trave ive (Teucrium montanum) i dobričice (Glechoma hederacea), koji rezultiraju ekstraktima izraženog bioaktivnog potencijala, ii) definiranje karakterističnih polifenolnih spojeva ispitivanih biljnih vrsta i metodologije njihovog izdvajanja, iii) definiranje bioloških učinaka (in vitro i in vivo) ekstrakata i polifenolnih frakcija, iv) učinkovita inkapsulacija ekstrakata i polifenolnih frakcija i v) implementacija inkapsuliranih sustava u proizvodnju novih funkcionalnih prehrambenih proizvoda.Postupci ekstrakcije optimizirat će se primjenom različitih tehnika (konvencionalne i inovativne) u cilju postizanja maksimalne ekstrakcijske učinkovitosti. Razvijenom metodologijom izdvojit će se karakteristične polifenolne frakcije (hidroksicimetne kiseline i flavonoidi) te će se ekstraktima i izdvojenim frakcijama detaljno utvrditi biološka aktivnost na odabranim staničnim linijama in vitro, a potom i na modelu štakora in vivo. Najučinkovitiji ekstrakti i polifenolne frakcije inkapsulirat će se tehnikama ekstruzije, sušenja raspršivanjem te, u tu svrhu razvijenom, tehnikom elektroispredanja, primjenom biopolimernih nosača, sa i bez dodatka biljnih proteina. Dobivenim inkapsulatima odredit će se fizikalno-kemijska i bioaktivna svojstva te će se isti koristiti u proizvodnji inovativnih proizvoda (čokolade, bombonski proizvodi, praškaste mješavine za napitke) kojima će se definirati funkcionalna i senzorska svojstva.Integracija postupaka ekstrakcije i inkapsulacije doprinijet će valorizaciji bioaktivnog potencijala tradicionalnih biljnih vrsta i unaprjeđenju proizvodnje novih funkcionalnih prehrambenih proizvoda, čijim konzumiranjem će se osigurati dostatni unos bioaktivnih spojeva i odgovarajući pozitivni zdravstveni učinci.]]></summary_hr><summary_en><![CDATA[According to the increasing demand of a modern consumer for new functional food products, the objectives of this project are: i) to define the most efficient extraction conditions of traditional, but insufficiently explored plant species: mountain germander (Teucrium montanum) and ground ivy (Glechoma hederacea), resulting in extracts with strong bioactive potential, ii) to define characteristic polyphenolic compounds and to develop their isolation methodologies, iii) to define biological effects of extracts and polyphenolic fractions in vitro and in vivo, iv) to establish efficient encapsulation of extracts and polyphenolic fractions and v) to implement the encapsulated systems in the production of new functional food products.Extraction procedures will be optimized using various techniques (conventional and innovative) in order to achieve maximum extraction efficiency.  The specially developed methodology will be used to isolate characteristic polyphenolic fractions (hydroxycinnamic acids and flavonoids) which will be evaluated, as well as the extracts, for biological activity using selected cell lines in vitro, and animal models (rats) in vivo.The most efficient extracts and polyphenolic fractions will be encapsulated by extrusion techniques, spray drying and, for this purpose developed, electrospinning technique, using biopolymeric carriers, plain or combined with plant proteins. The obtained encapsulates will be evaluated for physico-chemical and bioactive properties and further will be used in the production of innovative products (chocolate, candy products, powdered drink mixtures) with defined functional and sensory attributes.Integration of extraction and encapsulation techniques will contribute to the valorization of the bioactive potential of traditional plant species and to the improvement of the production of new functional food products, which upon consumption will provide sufficient intake of bioactive compounds and resulting specific health benefits.]]></summary_en></project><project>
<id>9176</id><title_hr><![CDATA[Utjecaj interneta i internetskih društvenih mreža na stavove i odluke o cijepljenju]]></title_hr><title_en><![CDATA[The Impact of the Internet and Internet Social Networking Sites on Attitudes and Decisions about Vaccination]]></title_en><user_id>19114</user_id><user_firstLast_name>Željko Pavić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-7902</code><acronim><![CDATA[INTERVAKC]]></acronim><duration>01.01.2020 - 31.12.2023</duration><status>Završio</status><financ_value>46.557,83 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Sociologija, Informacijske znanosti, </scie_field_hr><scie_field_en>Sociology, Information sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>20259, 19565, 19460, 26648, 26630, 26739, 13502, 27184, 27221, 27161, 856212, </team_members_id><team_members_names><![CDATA[Anita  Dremel, Gordana Lesinger, Adrijana Šuljok, Ljiljana Pintarić, Juraj Jurlina, Ivan Miškulin, Maja Miškulin, Aida Mujkić, Vesna Višekruna Vučina, Zvjezdana Lovrić Makarić, Emma Kovačević, ]]></team_members_names><keywords_hr><![CDATA[cijepljenje; antivakcinacijski pokret, Internet, internetske društvene mreže, znanstvena pismenost, sociokulturne promjene   ]]></keywords_hr><keywords_en><![CDATA[vaccination, antivax movement, Internet, Internet social networking sites, scientific literacy, socio-cultural changes]]></keywords_en><summary_hr><![CDATA[Unatoč verificiranim koristima, rašireno je odbijanje cijepljenja kao javnozdravstvene intervencije. Stoga je Svjetska zdravstvena organizacij otpore cijepljenju proglasila jednom od deset najvećih zdravstvenih prijetnji u 2019. godini. Uzroci otpora cijepljenju multidimenzionalni su te uključuju nisku razinu znanstvene pismenosti, sociokulturne vrijednosti i racionalni izbor. Rast upotrebe interneta pojavljuje se kao mehanizam koji pojačava te procese. Stoga je znanstveni cilj ovoga projekta istražiti moguće učinke interneta i internetskih društvenih mreža na stavove i odluke o cijepljenju. Teorijska je hipoteza da će internetska participacija biti povezana s negativnijim stavovima o cijepljenju, kao i da će negativni stavovi i ponašanje biti jače povezani s upotrebom interneta u usporedbi s upotrebom tzv. starih medija. Pri tome se pretpostavlja da će utjecaj medija biti posredovan razinom znanstvene pismenosti, manjim povjerenjem u institucije, odnosno postmodernim uvjerenjima o zdravlju. Medijacijski mehanizmi proizlaze iz teorijskog okvira koji obuhvaća komunikološke teorije (teoriju kultivacije), teorije u području znanstvene pismenosti (model deficita) te promjena sociokulturnih vrijednosti (Inglehartov model vrijednosnih promjena). Projekt tako integrira navedene teorije u jedinstven model. Provest će se četiri istraživanja (fokus grupe, analiza sadržaja, pilot istraživanje – N=500 i terensko anketno istraživanje na općoj populaciji RH – N=1.500). U istraživanjima će se upotrijebili validirane mjerne skale i posebno konstruirani instrumenti. Projekt će rezultirati objavom osam radova u Web of Science i Scopus publikacijama te sudjelovanjem na deset i organizacijom jedne konferencije. Projekt ima i izraženu javnozdravstvenu komponentu. Rezultati projekta sažet će se u priručnik koji bi se distribuirao liječnicima i drugim zainteresiranim javnostima. Rezultati projekta bit će predstavljeni i na konferencijama za medije i medijskim priopćenjima.]]></summary_hr><summary_en><![CDATA[Despite verified benefits, there is widespread rejection of vaccination as a public health intervention. The World Health Organization has declared vaccination as one of the top ten health threats in 2019. The causes of vaccine hesitancy are multidimensional and include low scientific literacy, socio-cultural values, and rational choice. Increasing internet usage seems to be a mechanism that enhances these processes. Therefore, the scientific aim of this project is to explore the possible effects of the Internet and Internet social networking sites on attitudes and decisions about vaccination. The project assumes that online participation will be associated with more negative attitudes about vaccination, and that negative attitudes and behaviors will be more strongly associated with the use of the Internet as compared to the use of so-called old media. It is assumed that the influence will be mediated by the scientific literacy, distrust of institutions, and postmodern health beliefs. Mediation mechanisms are derived from the theoretical framework that includes communication theories (theory of cultivation), theory of scientific literacy (the deficit model) and changes of sociocultural values (Inglehart&#39;s model of value changes). The project integrates these theories into a unique model. Four research (focus groups, content analysis, pilot study - N = 500 and field survey on the general population of Croatia - N = 1,500) will be conducted. Validated measurement scales and specially constructed instruments will be used. The project will result in the publication of eight papers in the Web of Science and Scopus indexed publications, participation in ten and the organization of one conference. The project also has a pronounced public health component. The results of the project will be summarized in a manual to be distributed to doctors and other interested citizens, and they will be presented at press conferences and through media releases and press conferences.]]></summary_en></project><project>
<id>9178</id><title_hr><![CDATA[Molekularna epidemiologija, kliničke osobitosti i skrb za osobe zaražene HIV-om u Hrvatskoj]]></title_hr><title_en><![CDATA[Molecular epidemiology, clinical features and care for HIV infection in Croatia]]></title_en><user_id>1084</user_id><user_firstLast_name>Josip Begovac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-9702</code><acronim><![CDATA[MEKOSH/MECCHC]]></acronim><duration>01.02.2020 - 31.01.2024</duration><status>Završio</status><financ_value>124.693,08 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Clinical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>26031, 1093, 1108, 1082, 4080, 3952, 3951, 4412, 1038, 12478, </team_members_id><team_members_names><![CDATA[Ivana Benković, Šime  Zekan, Vanja Romih Pintar, Klaudija Višković, Snježana Židovec Lepej, Lana Gorenec, Ivana Grgić, Oktavija Đaković Rode, Davorka  Lukas, Ana Planinić, ]]></team_members_names><keywords_hr><![CDATA[HIV, podtipovi, rezistencija, sekvencioniranje, ateroskleroza, sifilis, događaji, mHealth]]></keywords_hr><keywords_en><![CDATA[HIV, subtypes, resistance, sequencing, atherosclerosis, syphilis, events, mHealth]]></keywords_en><summary_hr><![CDATA[Usprkos uspješnom liječenje zaraza HIV-om je i nadalje važan javnozdravstveni problem. Molekularna epidemiologija se mijenja u smislu sve veće pojave klastera infekcija, rezistencija na nove lijekove, osobito inhibitora integraze se sve češće otkriva. Popratne bolesti poput glavnih kliničkih događaja (npr. infarkt miokarda, maligne bolesti, dijabetes, kronična bubrežna bolest, dekompenzacije jetre) se sve češće opažaju, a neke poput periferne ateroskleroze su nedovoljno ispitane. Epidemiologija sifilisa se proteklih godina značajno promijenila. Pristup skrbi se danas također mijenja jer postoje brojni novi uređaji i nove metode komunikacije. Mnoge ot tih novih komunikacija mHealth nisu dovoljno ispitane u odnosu na kvalitetu i dostupnost zdravstvene skrbi. Radi se o istraživanju koje ima više ciljeva: 1) Istraživanje molekularne epidemiologije HIV-1 infekcije (cilj A), 2) istraživanja prevalencije primarne rezistencije HIV-a na antiretrovirusne lijekove (cilj B), 3) Ispitati prevalenciju i incidenciju glavnih kliničkih događaja u osoba zaraženih HIV-om u Hrvatskoj te utvrditi čimbenike povezane s tim događajima, u razdoblju od 2019. do 2022. g. (cilj C) 4) Istražiti utjecaj HIV infekcije na perifernu ateroskleroze (cilj D), 5) odrediti incidenciju i prevalenciju sifilisa te učinkovitost liječenja u osoba zaraženih HIV-om u Hrvatskoj (cilj E) te 6) ispitati kako aplikacija mHealth „EmERGE“ utječe na skrb osoba zaraženih HIV-om (cilj F). Krajnji cilj je da rezultati ovog istraživanja doprinesu unaprjeđivanju skrbi oboljelih od HIV-infekcije, a da se putem molekularne epidemiologe uspješnije provodi prevencija HIV-infekcije.]]></summary_hr><summary_en><![CDATA[Despite the success of HIV therapy, HIV infection is still an important public health issue. Molecular epidemiology is changing in the sense that clusters do significantly contribute to new infections, resistance to new drugs, especially the integrator inhibitors, is also increasingly detected. Comorbidities such as major clinical events (eg myocardial infarction, malignant diseases, diabetes, chronic kidney disease, liver decompensation) are more commonly observed, and some such as peripheral atherosclerosis are underestimated. The epidemiology of syphilis has changed significantly in recent years. Access to care today is also changing because there are many new devices and new communication methods. Many of these new mHealth communications have not been sufficiently tested against the quality and impact on the health care system. Our project has multiple goals: 1) Investigating the molecular epidemiology of HIV-1 infection (goal A), 2) the prevalence of primary HIV resistance to antiretroviral drugs (goal B), 3) to examine the prevalence and incidence of major clinical events in (goal C) 4) to investigate the impact of HIV infection on peripheral atherosclerosis (goal D), 5) to determine the incidence and prevalence of syphilis in HIV infected people in Croatia and to determine the factors associated with them in the period 2019-2022 and to assess the effectiveness of treatment of syphilis in people infected with HIV in Croatia (goal E) and 6) to examine how the mHealth &#39;&#39;EmERGE&#39;&#39; application affects the care of people infected with HIV (goal F). The ultimate goal is that the results of this research contribute to improving the care of HIV-infected people, and that through the molecular epidemiologic investigation HIV infection prevention becomes more successful.]]></summary_en></project><project>
<id>9191</id><title_hr><![CDATA[Okvir za kontrolu i nadzor bespilotnih letjelica]]></title_hr><title_en><![CDATA[Unmanned Aerial Vehicle policy ecosystem]]></title_en><user_id>12678</user_id><user_firstLast_name>Neven Vrček</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2019-04</proposal_call><code>IP-2019-04-4864</code><acronim><![CDATA[ORKAN]]></acronim><duration>01.02.2020 - 31.01.2024</duration><status>Završio</status><financ_value>69.736,55 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Informacijske znanosti, Interdisciplinarne društvene znanosti, </scie_field_hr><scie_field_en>Information sciences, Interdisciplinary social sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet organizacije i informatike]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Organization and Informatics]]></institution_en><team_members_id>26374, 2725, 26519, 5699, 12786, 26634, 24249, 891, 202, 27387, 2900, 29712, 866659, 29112, 866990, 865470, </team_members_id><team_members_names><![CDATA[Mario Šercer, Ivan Magdalenić, Luka Milić, Renata Mekovec, Sandro Gerić, Marko Mijač, Zlatko Stapić, Markus Schatten, Boris Tomaš, Karl Sölvi Gudmundsson, Nikola Ivković, Elvis Popović, Lovro Posarić, Snježana Križanić, Mislav Matijević, Ahmed Shareef, ]]></team_members_names><keywords_hr><![CDATA[provedba zakona, lokalizacija signala, energetski učinkovita komunikacija, autonomne letjelice, jata, dronovi, konstelacija dronova]]></keywords_hr><keywords_en><![CDATA[policy enforcement, signal localization, energy efficient communication, unmammed aeral vehicle, swarm, drone, drone constellation]]></keywords_en><summary_hr><![CDATA[ORKAN je projekt koji istražuju različite okvire politike i definira najbolje prakse u pogledu na stvaranje politike glede sigurnosti i privatnosti. Ne postoji niti jedan set transparentnih pravila u vezi javne uporabe UAV za komercijalne i nekomercijalne svrhe. ORKAN ih definira tako da se mogu primijeniti u bilo kojem pravnom sustavu.Tu je naglasak na provođenje politike gdje ćemo istražiti i definirati protokole, algoritme i tehnologija za lokalizaciju  UAV pilota. Za to ćemo koristiti nasjnovija dostignuća na području za obradu i analizu radio signala. Jedinica za lokalizaciju je čitava UAV konstelacija koja koristi novi energetski učinkovit komunikacijski protokol koji je sastavni dio ovog projekta. Naše rješenje treba prepoznati kontrolni signal uljeza u EM spektru.  Koristeći ovaj signal konstelacija dronova (UAV) će skenirati i lokalizirati pilota. Nakon uspješnog lokalizacije, lokacija pilota je proslijeđena nadležnima.]]></summary_hr><summary_en><![CDATA[ORKAN is a project that investigated various policy frameworks and defines best practices regarding policy making concerning security and privacy. There is no single  and transparent set of rules regarding public use of UAV for commercial and non commercial purposes. ORKAN defines such that can be implemented in any legal system.There is an emphasis on policy enforcement where we will investigate and define protocols, algorithms and technologies for UAV pilot localization. To do that we will utilize state of the art achievements in the field for radio signal processing and analysis. y efficient communication protocol that is a part of this project. Our solution should identify intruder control signal in EM spectrum. Unit for localization is UAV constellation that uses new energUsing this signal constellation of drones will scan and localize the pilot. After successful localization, pilot location is forwarded to law enforcement unit.]]></summary_en></project><project>
<id>9238</id><title_hr><![CDATA[Održive turističke strategije za očuvanje i valorizaciju prirodne baštine mediteranske obale i priobalja]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6568</user_id><user_firstLast_name>Ana Težak Damijanić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-7689</code><acronim><![CDATA[]]></acronim><duration>27.07.2020 - 26.07.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, </scie_field_hr><scie_field_en>Economy, </scie_field_en><institution_hr><![CDATA[Institut za poljoprivredu i turizam]]></institution_hr><institution_en><![CDATA[Institute of Agriculture and Tourism in Poreč]]></institution_en><team_members_id>855634</team_members_id><team_members_names><![CDATA[ Doktorand: Marija Pičuljan ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>9239</id><title_hr><![CDATA[Formuliranje inkapsuliranih sustava bioaktivnih sastojaka tradicionalnih biljnih vrsta: trave ive i dobričice namijenjenih razvoju inovativnih funkcionalnih prehrambenih proizvoda]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4544</user_id><user_firstLast_name>Draženka Komes</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-6193</code><acronim><![CDATA[FUNCBIOCAP]]></acronim><duration>19.10.2020 - 18.10.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Prehrambena tehnologija, </scie_field_hr><scie_field_en>Food technology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Food Technology and Biotechnology]]></institution_en><team_members_id>858412</team_members_id><team_members_names><![CDATA[ Doktorand: Ana Mandura ]]></team_members_names><keywords_hr><![CDATA[bioaktivni spojevi, dobričica, ekstrakcija, funkcionalni proizvodi, inkapsulacija, polifenoli, trava iva]]></keywords_hr><keywords_en><![CDATA[bioactive compounds, ground ivy, extraction, functional products, encapsulation, polyphenols, mountain germander]]></keywords_en><summary_hr><![CDATA[Sukladno povećanoj potražnji suvremenog potrošača za novim funkcionalnim prehrambenim proizvodima, ciljevi ovog projekta su: i) definiranje najučinkovitijih postupaka ekstrakcije tradicionalnih, a nedovoljno istraženih, biljnih vrsta: trave ive (Teucrium montanum) i dobričice (Glechoma hederacea), koji rezultiraju ekstraktima izraženog bioaktivnog potencijala, ii) definiranje karakterističnih polifenolnih spojeva ispitivanih biljnih vrsta i metodologije njihovog izdvajanja, iii) definiranje bioloških učinaka (in vitro i in vivo) ekstrakata i polifenolnih frakcija, iv) učinkovita inkapsulacija ekstrakata i polifenolnih frakcija i v) implementacija inkapsuliranih sustava u proizvodnju novih funkcionalnih prehrambenih proizvoda.Postupci ekstrakcije optimizirat će se primjenom različitih tehnika (konvencionalne i inovativne) u cilju postizanja maksimalne ekstrakcijske učinkovitosti. Razvijenom metodologijom izdvojit će se karakteristične polifenolne frakcije (hidroksicimetne kiseline i flavonoidi) te će se ekstraktima i izdvojenim frakcijama detaljno utvrditi biološka aktivnost na odabranim staničnim linijama in vitro, a potom i na modelu štakora in vivo. Najučinkovitiji ekstrakti i polifenolne frakcije inkapsulirat će se tehnikama ekstruzije, sušenja raspršivanjem te, u tu svrhu razvijenom, tehnikom elektroispredanja, primjenom biopolimernih nosača, sa i bez dodatka biljnih proteina. Dobivenim inkapsulatima odredit će se fizikalno-kemijska i bioaktivna svojstva te će se isti koristiti u proizvodnji inovativnih proizvoda (čokolade, bombonski proizvodi, praškaste mješavine za napitke) kojima će se definirati funkcionalna i senzorska svojstva.Integracija postupaka ekstrakcije i inkapsulacije doprinijet će valorizaciji bioaktivnog potencijala tradicionalnih biljnih vrsta i unaprjeđenju proizvodnje novih funkcionalnih prehrambenih proizvoda, čijim konzumiranjem će se osigurati dostatni unos bioaktivnih spojeva i odgovarajući pozitivni zdravstveni učinci.]]></summary_hr><summary_en><![CDATA[According to the increasing demand of a modern consumer for new functional food products, the objectives of this project are: i) to define the most efficient extraction conditions of traditional, but insufficiently explored plant species: mountain germander (Teucrium montanum) and ground ivy (Glechoma hederacea), resulting in extracts with strong bioactive potential, ii) to define characteristic polyphenolic compounds and to develop their isolation methodologies, iii) to define biological effects of extracts and polyphenolic fractions in vitro and in vivo, iv) to establish efficient encapsulation of extracts and polyphenolic fractions and v) to implement the encapsulated systems in the production of new functional food products.Extraction procedures will be optimized using various techniques (conventional and innovative) in order to achieve maximum extraction efficiency.  The specially developed methodology will be used to isolate characteristic polyphenolic fractions (hydroxycinnamic acids and flavonoids) which will be evaluated, as well as the extracts, for biological activity using selected cell lines in vitro, and animal models (rats) in vivo.The most efficient extracts and polyphenolic fractions will be encapsulated by extrusion techniques, spray drying and, for this purpose developed, electrospinning technique, using biopolymeric carriers, plain or combined with plant proteins. The obtained encapsulates will be evaluated for physico-chemical and bioactive properties and further will be used in the production of innovative products (chocolate, candy products, powdered drink mixtures) with defined functional and sensory attributes.Integration of extraction and encapsulation techniques will contribute to the valorization of the bioactive potential of traditional plant species and to the improvement of the production of new functional food products, which upon consumption will provide sufficient intake of bioactive compounds and resulting specific health benefits.]]></summary_en></project><project>
<id>9240</id><title_hr><![CDATA[Istraživanje shizofrenije kroz ekspresiju netopivih proteina]]></title_hr><title_en><![CDATA[]]></title_en><user_id>22771</user_id><user_firstLast_name>Nicholas Bradshaw</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-8580</code><acronim><![CDATA[CandidIskren]]></acronim><duration>15.10.2020 - 13.06.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Interdisciplinarno područje znanosti</scie_area_hr><scie_area_en>Interdisciplinary scientific area</scie_area_en><scie_field_hr>Biotehnologija u biomedicini, </scie_field_hr><scie_field_en>Biotechnology in Biomedicine, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Fakultet biotehnologije i razvoja lijekova]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Biotechnology and Drug Development]]></institution_en><team_members_id>29297</team_members_id><team_members_names><![CDATA[ Doktorand: Bobana Samardžija ]]></team_members_names><keywords_hr><![CDATA[Shizofrenija, Mentalna bolest, Agregiranje proteina, Drosophila, Neuroznanost]]></keywords_hr><keywords_en><![CDATA[Schizophrenia, Mental illness, Protein Aggregation, Drosophila, Neuroscience]]></keywords_en><summary_hr><![CDATA[Schizofrenija, bipolarni poremećaj i teška depresija su devastirajuće mentalne bolesti s jako kompliciranom genetskom pozadinom. U cilju izbjegavanja složenosti genetike, predlažemo istraživanje izravno na proteinima uključenim u staničnu patologiju. Inspiraciju smo dobili zahvaljujući spoznajama neurodegenerativnih bolesti, kao što su Alzheimerova i Parkinsonova bolest, u kojima specifični proteini formiraju netopive krivo smotane agregate u mozgu. Radna hipoteza je da poremećena proteostaza može također biti razlog kroničnim mentalnim bolestima. Rezultati istraživanja upućuju na pet proteina koji potencijalno formiraju netopive agregate u mozgu dijela pacijenata s teškim mentalnim bolestima. To su: CRMP1. DISC1, dysbindin-1, NPAS3 and TRIOBP-1. Do danas nije poznato da li ovi proteini agregiraju zajedno ili imaju kumulativni efekt u istom pacijentu.Predloženi projekt ima za cilj integrativni pristup istraživanju agregacije ovih pet proteina. Biti će određena regija neophodna za agregaciju i iskorištena za sintezu mutiranih formi koje imaju ili nemaju sposobnost stvaranja agregata. Potom će divlji tip i mutant protein biti analizirani u cilju određivanja posljedice agregacije, bilo zasebno ili u kombinaciji. Istraživat će se na neuronima sličnim staničnim kulturama da se odrede posljedice agregata na razvoj, i također na transgenoj vinskoj mušici - Drosophila u cilju testiranja utjecaja na ponašanje.Eksperimente koje predlažemo, u budućnosti mogu poslužiti za analizu proteinskih agregata mentalnih bolesti u kompleksnijim trensgenim modelima. Također će omogućiti važne spoznaje o mogućoj uporabi agregata kao dijagnostičkih biomarkera i meta budućim terapeutskim intervencijama.]]></summary_hr><summary_en><![CDATA[Schizophrenia, bipolar disorder and major depression are devastating mental illnesses with a highly complicated genetic background. In order to circumvent this, we have proposed studying directly proteins involved in their cellular pathology. Specifically, we have taken inspiration from neurodegenerative conditions, such as Alzheimer&#39;s disease or Parkinson&#39;s disease, in which specific proteins form insoluble misfolded aggregates in the brain. We therefore hypothesised that disrupted proteostasis may also be a component of chronic mental illness. Data now exists implicating five proteins as potentially forming insoluble aggregates in the brains of subsets of patients with major mental illness: CRMP1, DISC1, dysbindin-1, NPAS3 and TRIOBP-1. To date however, it is not clear whether these proteins aggregate together or have cumulative effects on the same patients.The project proposed here therefore aims to take an integrative approach to studying the aggregation of these five proteins. The regions of these proteins required for aggregation will be determined and used to design mutant forms of them which either have or lack the ability to form aggregates. These wild-type and mutant proteins will then be investigated, in order to determine the consequences of aggregation of the proteins, both individually and in combination. This will be performed both in neuronal-like cell culture systems, in order to determine the consequences of aggregation on development, and also in transgenic Drosophila fruit flies in order to test their effects on behaviour.The experiments proposed here will aid in the design of more complex transgenic models of proteins aggregation in mental illness. They will also provide important insight into the potential value of such aggregates both as diagnostic biomarkers and as targets for future therapeutic interventions.]]></summary_en></project><project>
<id>9242</id><title_hr><![CDATA[Istraživanje i razvoj novih mikro i nanostrukturnih bioaktivnih materijala u dentalnoj medicini]]></title_hr><title_en><![CDATA[]]></title_en><user_id>12362</user_id><user_firstLast_name>Ivana Miletić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-5603</code><acronim><![CDATA[BIODENTMED]]></acronim><duration>22.10.2020 - 21.10.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Dentalna medicina, </scie_field_hr><scie_field_en>Dental medicine, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Stomatološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Dentistry]]></institution_en><team_members_id>858408</team_members_id><team_members_names><![CDATA[ Doktorand: Ivan Šalinović ]]></team_members_names><keywords_hr><![CDATA[bioaktivnost, staklenoionomeri, kalcij silikatni cementi, vlakna, nanočestice, mikro CT, metoda konačnih elemenata]]></keywords_hr><keywords_en><![CDATA[bioactivity, glass-ionomers, calcium silicate cements, fibers, nanofillers, micro CT, finite element method]]></keywords_en><summary_hr><![CDATA[Svrha projekta je interdisciplinarno ispitivanje i poboljšanje svojstava bioaktivnih materijala koji se primjenjuju u različitim granama dentalne medicine. Prvi dio istraživanja usmjeren je na bioaktivne staklenoionomerne cemente. Ti materijali ostvaruju kemijsku vezu s površinom zuba, imaju remineralizirajući i kariostatski učinak. Međutim, njihovi nedostatci su još uvijek slaba fizičko-mehanička svojstva. Prvi cilj ovog projekta je istražiti mogućnost njihova poboljšanja dodavanjem staklenih vlakana i nanočestica u različitim omjerima te ispitati njihovu čvrstoću, tvrdoću, modul elastičnosti, remineralizacijski potencijal i adhezivnost na površinu zuba. U drugom dijelu istraživanja provest će se analiza biokeramike kao predstavnika novog bioaktivnog materijala za punjenje korijenskih kanala. Biokeramika bi trebala djelovati stimulativno na vitalno tkivo parodonta i dobro brtviti korijenski kanal. Stoga je drugi cilj projekta procijeniti odnos biokeramičkih materijala i strukture zuba u endodontskom prostoru ispitivanjem kvalitete brtvljenja ispuna korijenskog kanala biokeramikom prije i nakon dinamičkog opterećenja te mogućnost uklanjanja biokeramičkih materijala nakon revizije mikro CT analizom. Dinamičkim opterećenjem  nastoje se postići uvjeti slični onima u stomatognatom sustavu što je potrebno za ispravnu procjenu ponašanja materijala u kliničkim uvjetima. Temeljem podataka dobivenih laboratorijski i metodom konačnih elemenata odredit će se biomehanička i biomimetička svojstva istraživanih materijala. Originalnost predloženog istraživanja očituje se u sveobuhvatnom ispitivanju bioaktivnih materijala i doprinijet će boljem razumijevanju njihove strukture i svojstava te omogućiti razvoj poboljšanih protokola njihove kliničke primjene. Također, rezultati analize različitih ojačanja biomaterijala usmjerit će istraživanja prema njihovom daljnjem razvoju.]]></summary_hr><summary_en><![CDATA[The aim of the project is an interdisciplinary investigation and the enhancement of properties of bioactive materials properties used in different fields of dental medicine. The first part of the research is focused on bioactive glassionomer cements.  These materials chemically bond to the tooth surface and have a remineralizing and cariostatic effect. However, their disadvantages are poor physico-mechanical properties. The first aim of this project is to investigate the possibility of enhancing glassionomers by adding fibers and nanoparticles in different ratios and to assess the strength, hardness, modulus of elasticity, remineralizing potential and adhesion to the tooth surface.  Subsequently, the project will be focused on investigation of bioceramics as a representative of a new bioactive material for root canal filling. Bioceramics should stimulate the vital periodontal tissue and provide a good seal. Therefore, the second aim of the project is to assess the relation of bioceramic materials and tooth structure in the endodontic system by investigating the sealing ability before and after dynamic loading and the possibilities of the removal of bioceramics using micro CT. With dynamic loading, we are attempting to recreate the conditions similar to those in oral cavity which is necessary to correctly assess the behaviour of the materials under clinical conditions. With the data obtained in the laboratory and by finite element method biomechanical and biomimetic properties of the investigated materials will be determined. The originality of the proposed research lies in the detailed assessment of bioactive materials which should result in the better understanding of its structure and properties. It should also enable the development of better protocols for clinical application of the materials. Furthermore, the results of the analysis of different reinforcements of biomaterials will direct research towards enabling the materials to evolve even further.]]></summary_en></project><project>
<id>9244</id><title_hr><![CDATA[Europski režim iregulariziranih migracija na periferiji EU: od etnografije do pojmovnika]]></title_hr><title_en><![CDATA[]]></title_en><user_id>19338</user_id><user_firstLast_name>Marijana  Hameršak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-5874</code><acronim><![CDATA[ERIM]]></acronim><duration>01.10.2020 - 30.06.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Etnologija i antropologija, </scie_field_hr><scie_field_en>Ethnology and anthropology, </scie_field_en><institution_hr><![CDATA[Institut za etnologiju i folkloristiku]]></institution_hr><institution_en><![CDATA[Institute of Ethnology and Folklore Research in Zagreb]]></institution_en><team_members_id>856144</team_members_id><team_members_names><![CDATA[ Doktorand: Bojan Mucko ]]></team_members_names><keywords_hr><![CDATA[balkanska ruta, Europska unija, granice, iregularnost/iregularizacija, migracije, multilokalna etnografija, periferija, režim migracija ]]></keywords_hr><keywords_en><![CDATA[Balkan route, borders, European Union, irregularity/irregularization, migration regime,  migration, multi-sited ethnography, periphery]]></keywords_en><summary_hr><![CDATA[Europski režim migracija i iregularizirana migrantska kretanja, pa tako i ona balkanskom rutom koja presijeca i Hrvatsku, ključni su fenomeni današnjice koji zahtijevaju i znanstvenu elaboraciju. Istraživanje tih fenomena, osobito na jugoistočnim granicama Europske unije, obilježeno je unutrašnjom disperziranošću, tematskom fragmentiranošću te nedovoljnom društvenom i međunarodnom vidljivošću. Stoga se već dulje uočava potreba za stvaranjem jake istraživačke grupe koja bi kontinuirano pratila i analizirala režim iregulariziranih migracija u transnacionalnom prostoru koji zahvaća Hrvatsku i zemlje okružja, a oblikovan je često cirkularnim migrantskim kretanjima.  Projektom ERIM teži se odozdo, polazeći  od multilokalnih etnografskih terenskih istraživanja metodama promatranja, sudjelovanja, intervjua i dr., zahvatiti razine i iskustva različitih dionika, od  migranata, preko članova lokalnih zajednica do zaposlenika i predstavnika tijela lokalnih vlasti, međunarodnih i drugih organizacija. U otklonu od razumijevanja režima migracija kao označitelja apstraktne i monolitne moći države, ERIM, dakle, režimu iregulariziranih migracija  pristupa kao dinamičnom polju heterogenih, pa i suprotstavljenih praksi i interakcija različitih aktera, koje se pritom na specifične načine artikuliraju na periferijama EU. Cilj projekta je višerazinski dokumentirati i istražiti te specifičnosti i ponuditi njihove empirijski utemeljene i teorijski relevantne konceptualizacije. Očekivanim rezultatima (prije svega pojmovnikom tj. mrežom etnografski dokumentiranih i analitički elaboriranih pojmova u okviru pojedinačnih znanstvenih radova, projektne publikacije, kao i multimedijalne mrežne platforme e-ERIM) nastojat će se pridonijeti dubljem razumijevanju kontradikcija i potencijala pojma režima migracija i iregulariziranih migrantskih kretanja u akademskoj, ali i široj društvenoj sferi.]]></summary_hr><summary_en><![CDATA[The European migration regime and irregularized migration movements, including those along the Balkan route that crosses Croatia, among other countries, are key contemporary phenomena that require academic study. Research into these phenomena, especially at the southeastern borders of the EU, has been characterized by internal dispersion, thematic fragmentation and insufficient social and international visibility. Therefore, a need to form a strong research group, which would continuously document and analyze the irregularized migration regime in the transnational space that includes Croatia and the surrounding countries and is shaped by often circular migrant movements, has been evident for some time now. Based on multi-sited ethnographic fieldwork (observation, participation, interviews and other methods), the ERIM project aims to encompass the levels and experiences of different stakeholders, from migrants, to members of local communities, and employees and representatives of local authorities, international and other organizations. By distancing from the notion that the migration regime is a signifier of the abstract and monolithic power of the state, ERIM approaches the irregularized migration regime as a dynamic field of heterogeneous and even opposed practices and interactions of various actors that are articulated in specific ways on the peripheries of EU. The goal of the project is to document and explore these specifics on multiple levels, and to offer their empirically based and theoretically relevant conceptualizations. The expected outcomes (primarily, the keywords i.e. a network of analytically elaborated concepts within the individual research papers, project publications, and the e-ERIM multimedia platform) will be aimed at contributing to a deeper understanding of the contradictions and potentials of the concept of migration regime and irregularized migrant movements in the academic, but also in the broader social sphere.]]></summary_en></project><project>
<id>9246</id><title_hr><![CDATA[Train to Enforce]]></title_hr><title_en><![CDATA[]]></title_en><user_id>618</user_id><user_firstLast_name>Ivana Kunda</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-8875</code><acronim><![CDATA[]]></acronim><duration>14.09.2020 - 13.09.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Pravo, </scie_field_hr><scie_field_en>Law, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Pravni fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Law]]></institution_en><team_members_id>856042</team_members_id><team_members_names><![CDATA[ Doktorand: Martina Tičić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>9248</id><title_hr><![CDATA[Antibiotička rezistencija u uređajima za obradu otpadnih voda u Hrvatskoj – naglasak na ß-laktamaze proširenog spektra i karbapenemaze ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>12566</user_id><user_firstLast_name>Nikolina Udiković Kolić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-3688</code><acronim><![CDATA[]]></acronim><duration>13.10.2020 - 12.10.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Biotehnologija, </scie_field_hr><scie_field_en>Biotechnology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>857304</team_members_id><team_members_names><![CDATA[ Doktorand: Ana Puljko ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>9249</id><title_hr><![CDATA[Predplanirana i reaktivna agilnost; razvoj i validacija specifičnih metoda mjerenja, utvrđivanje faktora utjecaja i učinkovitost transformacijskih postupaka]]></title_hr><title_en><![CDATA[]]></title_en><user_id>147</user_id><user_firstLast_name>Damir Sekulić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-9298</code><acronim><![CDATA[RAGCODS]]></acronim><duration>01.10.2020 - 01.10.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Kineziologija, </scie_field_hr><scie_field_en>Kinesiology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Kineziološki fakultet]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Kinesiology]]></institution_en><team_members_id>856001</team_members_id><team_members_names><![CDATA[ Doktorand: Toni Modrić ]]></team_members_names><keywords_hr><![CDATA[testovi, prediktori, povezanost, utjecaj, agilnost otvorene vještine, agilnost zatvorene vještine]]></keywords_hr><keywords_en><![CDATA[tests, predictors, associations, influence, open skill agility, closed skill agility]]></keywords_en><summary_hr><![CDATA[Poznata je važnost agilnosti u sportu, ali je u skorije vrijeme prepoznata njena važnost i izvan natjecateljskog sporta. Utvrđeno je postojanje dva manifestacijska oblika agilnosti: pred-planirane agilnosti (CODS) i reaktivne agilnosti (RAG). Ciljevi projekta su: (i) razviti testove za mjerenje RAG i CODS, (ii) utvrditi faktore utjecaja na RAG i CODS, (iii) provjeriti učinkovitost transformacijskih programa (treninga) u razvoju RAG i CODS; za sportaše i kliničku populaciju. Uzorak ispitanika činiti će sportaši i klinička populacija (svi stariji od 18 godina). Skupinu sportaša činiti će podskupine: rukometaši (n = 60; 50% žena), košarkaši (n = 60; 50% žena), vaterpolisti (n = 60; 50% žena) i igrači fustala (n = 60; 50% žena). Kliničku populaciju činiti će osobe starije od 50 godina koje će se nalaziti na postoperativnom tretmanu nakon operativnog zahvata zamjena zgloba ili artroskopske operacije koljena (n=100; 50% žena). Zavisne varijable biti će novokonstruirani testovi RAG i CODS. Nezavisne varijable biti će antropometrijske mjere i mjere sastava tijela (za sve skupine), mjere brzine, sile, eksplozivne snage i reaktivne snage (za sportaše). Najprije će se razviti i validirati testovi RAG i CODS temeljeni na bežičnim tehnologijama. Potom će se utvrditi povezanost nezavisnih i zavisnih varijabli. Konačno, provjeriti će se efikasnost specifičnih treninga u razvoju RAG i CODS. Metode obrade rezultata uključivati će procjenu metrijskih karakteristika testova, univarijatne i multivarijatne analize povezanosti nezavisnih i zavisnih varijabli, te analize za procjenu učinkovitosti treninga. Radit će se o jednom od prvih istraživanja u svijetu u kojem će se razviti testovi za mjerenje RAG i CODS u različitim sportovima, koje će sistematski istražiti problem RAG i CODS kod analizirane kliničke populacije, te koje će istražiti učinkovitost treninga RAG i CODS. Projekt će imati izravnu primjenu u sportskom treningu i postoperativnoj rehabilitacijskoj praksi.]]></summary_hr><summary_en><![CDATA[The importance of agility in sport is well known, and since recently the significance of this quality is recognized in non-athletic population. Two facets of agility are recognized, differentiating reactive agility (RAG), and change of direction speed (CODS). The aims of this project are: (i) to develop RAG and CODS tests, (ii) to identify predictors of RAG and CODS, (iii) to define efficacy of training aimed at development of RAG and CODS; in athletic- and non-athletic (clinical) participants. The sample will comprise athletes, and clinical sample. The athletes will be involved in handball (n = 60; 50% females), basketball (n = 60; 50% females), water polo (n = 60; 50% females), and futsal (n = 60; 50% females), Clinical sample will comprise 100 participants (50% females, > 50 years) patients at postoperative treatment after joint replacement or arthroscopic knee surgery. The developed tests of RAG and CODS will be observed as dependent variables (DV). The independent (IV) variables will comprise anthropometric/body composition indices (for all participants), sprinting-, power-, force-, and reactive-strength-capacites (for athletes). First, tests of RAG and CODS will be evaluated for reliability and validity. Next, relationships between IV and DV will be established. Finally, the efficacy of the training aimed at improvement of RAG and CODS will be evaluated. Statistics will include analyses aimed at evaluation of (i) reliability and validity of tests, (ii) relationships among variables, and (iii) evaluation of training effects. This investigation will be one of the first which will systematically develop and validate RAG and CODS tests in different sports and clinical population, and probably the first one where the problem of development of RAG and CODS will be systematically investigated. The findings will have direct implications in sports training, as well as in postoperative rehabilitation of an investigated clinical sample.  ]]></summary_en></project><project>
<id>9250</id><title_hr><![CDATA[Daljinsko praćenje erozije riprap zaštite od podlokavanja na velikim rijekama u stvarnom vremenu]]></title_hr><title_en><![CDATA[]]></title_en><user_id>20384</user_id><user_firstLast_name>Kristina Potočki</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-5354</code><acronim><![CDATA[R3PEAT]]></acronim><duration>05.10.2020 - 31.08.2026</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Građevinarstvo, </scie_field_hr><scie_field_en>Civil engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Građevinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Civil Engineering]]></institution_en><team_members_id>856175</team_members_id><team_members_names><![CDATA[ Doktorand: MARTINA KOVAČEVIĆ ]]></team_members_names><keywords_hr><![CDATA[Zaštita od podlokavanja, urušavanje riprapa, fizički model, hibridno modeliranje, remote sensing]]></keywords_hr><keywords_en><![CDATA[Scour protection, riprap subsidence, physical model, hybrid modelling, daljinsko istraživanje]]></keywords_en><summary_hr><![CDATA[Mjerenje hidrauličkih parametara tijekom nailaska velikih voda neophodno je za razumijevanje morfodinamičkog razvoja korita u blizini građevina, no istovremeno je mjerenje opasno i otežano zbog velike snage toka vode u blizini građevina. Ovim projektom planira se razviti sustav za daljinsko praćenje erozije riprap zaštite od podlokavanja na velikim rijekama u stvarnom vremenu za vrijeme velikih voda, kojim bi se omogućilo mjerenje u uvjetima koji ograničavaju primjenu tradicionalnih metoda. U tu svrhu planira se razviti prototip plutače ScourBuoy opremljene senzorima za daljinsko mjerenje dubine korita i svog prostornog kretanja. U ovom projektu istraživanje utjecaja velikovodnih događaja na razvoj kaverni temelji se na pristupu hibridnog modeliranja – združenog eksperimentalnog ispitivanja na fizičkom modelu umanjenog mjerila i numeričkih simulacija u mjerilu prototipa. Oba modela će biti verificirana podacima prikupljenim ScourBuoyom za dokazivanje pouzdanosti zaključaka izvedenih na temelju podataka modela. Doprinos predloženog istraživanja u odnosu na aktualno stanje područja ogleda se u premještanju težišta istraživanja na mostove oko kojih je već izvedena riprap zaštita od podlokavanja – postojećih građevina čija je stabilnost i s njom povezana sigurnost nepoznanica u hidrauličkom okolišu pod utjecajem klimatskih promjena i s njima povezanih velikovodnih događaja. Pojedinačni istraživački ciljevi projekta su: (1) unaprijediti postojeće empirijske zavisnosti za određivanje ravnotežnih karakteristika kaverne eksperimentalnim ispitivanjem u laboratoriju (faza I) i numeričkim simulacijama (faza II), (2) istražiti zavisnosti turbulentnih karakteristika toka i vremenskog razvoja kaverne te (3) ispitati uvjete u kojima dolazi do početnog pomaka čestica u kaverni. Implementacijom rezultata istraživanja u sustave gospodarenja mostovima omogućava pravovremeno donošenje odluka o mjerama i radnjama potrebnim za osiguranje stabilnosti mosta tijekom nailaska velikih voda.]]></summary_hr><summary_en><![CDATA[Field surveys of hydraulic parameters during floods is essential in understanding morphodynamic evolution of the river channel, while dangerous and difficult at the same time for field surveys due to the increased flow power in vicinity of the structures. The aim of this research is to develop “ScourBuoy, a remote real-time buoy for remote sensing of scouring and its own displacement. Development and progression of scouring under high flow conditions plans to be investigated using hybrid modelling approach – coupled experimental investigations on scaled physical model and numerical model in prototype scale. Both models will be verified using ScourBuoy field data in order to demonstrate the reliability of conclusions based on model generated data. Contribution of proposed project to state of the art research is focus shift towards the bridges that have installed riprap protection around them – existing structures whose stability and associated safety is unknown in hydraulic environment influenced by climate change. Project research goals are: (1) improve existing empirical equations for equilibrium scour hole size through experimental investigations in laboratory flume (phase I) and numerical simulations (phase II), (2) investigate dependence of temporal scour hole development on turbulent flow characteristics (3) investigate turbulent conditions for incipient motion of sediment particles. Implementation of results in bridge management systems enables timely decision-making implemented in plan of action mandatory to secure bridge stability during extreme flooding events.]]></summary_en></project><project>
<id>9252</id><title_hr><![CDATA[Environmental risk assessment and mitigation on Cultural Heritage assets in Central Asia (609574-EPP-1-2019-1-IT-EPPKA2-CBHE-JP)]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3063</user_id><user_firstLast_name>Davorin Penava</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-6812</code><acronim><![CDATA[]]></acronim><duration>01.11.2020 - 31.10.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Temeljne tehničke znanosti, </scie_field_hr><scie_field_en>Basic engineering sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Građevinski i arhitektonski fakultet Osijek]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Civil Engineering and Architecture Osijek]]></institution_en><team_members_id>858358</team_members_id><team_members_names><![CDATA[ Doktorand: Domagoj Trajber ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>9253</id><title_hr><![CDATA[Računalno projektiranje nanotranzistora temeljenih na novim 2D materijalima]]></title_hr><title_en><![CDATA[]]></title_en><user_id>7054</user_id><user_firstLast_name>Mirko Poljak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-7349</code><acronim><![CDATA[CONAN2D]]></acronim><duration>01.10.2020 - 01.10.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>856203</team_members_id><team_members_names><![CDATA[ Doktorand: Ante Zeljko ]]></team_members_names><keywords_hr><![CDATA[računska nanoelektronika, tranzistori, 2D materijali, skaliranje, atomistička simulacija, kvantni transport, NEGF, DFT]]></keywords_hr><keywords_en><![CDATA[computational nanoelectronics, transistors, 2D materials, scaling, atomistic simulation, quantum transport, NEGF, DFT]]></keywords_en><summary_hr><![CDATA[Predloženi projekt će istražiti karakteristike nanotranzistora temeljenih na novim dvodimenzionalnim materijalima otkrivenim nakon grafena, s fokusom na bizmuten. Istraživačka grupa će razviti napredni računalni program za atomističke simulacije i predviđanje performansi ovih nanotranzistora. Razvijeni program će spariti dvije napredne metode: ab initio teoriju funkcionala gustoće (DFT) i kvantni transport temeljen na formalizmu Greenove funkcije izvan termodinamičke ravnoteže (NEGF). DFT daje točnu strukturu energijskih pojaseva materijala s atomističkom rezolucijom, dok NEGF inherentno uključuje kvantnomehaničke efekte koji su prisutni u ekstremno skaliranim tranzistorima. Simulator ćemo implementirati na hibridnoj CPU-GPU platformi s paraleliziranim izvršenjem programskog koda da bi se omogućile simulacije na računalnom grozdu i na sveučilišnom superračunalu. Razvijeni alat će biti korišten za istraživanje utjecaja geometrije, dimenzija, materijala u stogu upravljačke elektrode i kristalnih defekata na karakteristike tranzistora. Provest će se projektiranje, istražiti mogućnosti optimizacije performansi i analizirati varijabilnost karakteristika uzrokovanu defektima. Ishodi istraživanja će odgovoriti na pitanje jesu li odabrani materijali ostvarive i uvjerljive alternative klasičnom volumnom siliciju i drugim 2D materijalima za sljedeće generacije poluvodičke tranzistorske tehnologije. Ovaj projekt će pružiti čvrstu osnovu za utemeljenje nove istraživačke grupe u području računske nanoelektronike. Uz programski paket, tehničku dokumentaciju, znanstvene publikacije i druge mjerljive rezultate, novoformirana grupa će doprinijeti izobrazbi hrvatskih studenata i istraživača što će unaprijediti njihove istraživačke i inovacijske kapacitete. Mreža potencijalnih suradnika, znanje i vještine koje će se steći za trajanja ovog projekta omogućit će buduće projektne prijave i osigurati snažan i održiv razvoj istraživačke grupe.]]></summary_hr><summary_en><![CDATA[The proposed project will explore the properties of nanoscale transistors implemented with novel two-dimensional materials beyond graphene, with a focus on bismuthene. Atomistic-level simulation software will be developed to simulate and predict the performance of these nanotransistors. The program will couple two state-of-the-art methods: ab initio density functional theory (DFT) and quantum transport based on non-equilibrium Green&#39;s function (NEGF) formalism. The DFT provides an accurate bandstructure with atomic resolution, while NEGF inherently covers quantum-mechanical effects present in extremely-scaled transistors. We will implement the simulator in a hybrid CPU-GPU platform with parallelized code execution in order to allow simulations on the computer cluster and university supercomputing facility. The simulation software will be employed to investigate the impact of device geometry, dimensions, gate stack materials and crystal defects on transistor characteristics. The results of this project will guide device design, explore possibilities for performance optimization, and assess device variability caused by defects. The outcomes of the research will answer the question of whether selected materials present feasible alternatives to bulk silicon and other contending 2D materials for next-generation transistor technologies. The project will provide a strong foundation for the establishment of an independent research group in the field of computational nanoelectronics. In addition to software, technical documentation, scientific publications and other project deliverables, the group will contribute to training of Croatian students and researchers, thus increasing their research and innovation capacities. Network of potential collaborators, knowledge, and expertise acquired during this project will facilitate future grant submissions that will ensure a strong and sustainable development of the research group.]]></summary_en></project><project>
<id>9254</id><title_hr><![CDATA[ISTRAŽIVAČKI NOVINARSKI LABORATORIJ: Vjerodostojnost medija kroz kulturu eksperimenta i inovacije u redakcijama]]></title_hr><title_en><![CDATA[]]></title_en><user_id>27365</user_id><user_firstLast_name>Tena Perišin</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-5026</code><acronim><![CDATA[JOURLAB]]></acronim><duration>16.12.2020 - 16.12.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Informacijske znanosti, </scie_field_hr><scie_field_en>Information sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet političkih znanosti]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Political Science]]></institution_en><team_members_id>864828</team_members_id><team_members_names><![CDATA[ Doktorand: Dejan Oblak ]]></team_members_names><keywords_hr><![CDATA[novinarstvo, vijesti, vjerodostojnost, inovacije, digitalna tehnologija, publike, novinarske prakse, redakcijske prakse]]></keywords_hr><keywords_en><![CDATA[journalism, news, credibility, innovation, digital technology, audiences, journalism practices, newsroom practices]]></keywords_en><summary_hr><![CDATA[Cilj projekta je istraživanje percepcije medija i informativnih sadržaja koji mediji u Hrvatskoj nude i istraživanja medijskih oblika kojima se može povećati kvaliteta informativnih sadržaja, interes javnosti te vjerodostojnost medija. Cilj projekta je i osmišljavanje i testiranje novih medijskih informativnih oblika, te uspostavljanje novinarskog laboratorija na Fakultetu političkih znanosti Sveučilišta u Zagrebu, u kojem bi se ovi sadržaji proizvodili i testirali prema uzoru na primjere dobre prakse na vrhunskim sveučilištima u SAD-u i Europi. U sklopu projekta provest će se istraživanje medijskih sadržaja kako bi se utvrdio njegov prevladavajući karakter s obzirom na sadržaj i formu. Provest će se i istraživanje percepcije medijskih sadržaja i oblika od strane medijskih publika, kako bi se utvrdilo kako one doživljavaju medijski sadržaj i formu s obzirom na kvalitetu informacija koje nudi, interes koji budi kod javnosti te vjerodostojnost. S istim ciljem će se provesti i istraživanje na praktičarima unutar medija kako bi se utvrdilo način na koji medijski sadržaj vide akteri koji ga proizvode i koliko se njihova percepcija razlikuje od percepcije medijskih publika. U sklopu projekta provest će se mapiranje inovativnih novinarskih praksi u međunarodnom kontekstu kako bi se identificirali primjeri dobrih praksi i pronašli obrasci koji će se koristiti u izradi inovativnih medijskih sadržaja, koji će se potom testirati na fokus skupinama. U tu svrhu projekt će razvijati inovativne oblike digitalnog novinarstva, načina na koji novinari stvaraju i prenose informacije, proizvode multimedijske audiovizualne priloge, te oblikuju nove načine prezentacije sadržaja koristeći digitalne alate. Konačno, ti oblici novinarskog izričaja izrađeni uz inovativne digitalne alate testirat će se u fokus grupama s predstavnicima medijskih publika i novinarima iz prakse.  ]]></summary_hr><summary_en><![CDATA[The project objective is the research of the perception of media informative content in Croatia, and research of media form which can be used in order to increase quality of informative content, public interest in them and media credibility. The project objective is creation and testing of the new media informative forms and establishment of the news lab at the Faculty of Political Science of Zagreb University, where this content would be produced and tested in accordance with good practices developed at universities in USA and Europe.The project will include research of media content in order to establish what form of content and form dominates. Perception of media content by the media public will also be performed in order to establish how media public see media content with respect to quality of information it offers, public interest it provokes and credibility. With the same objective the project will research practitioners within media in order to establish how media content is seen by the actors that produce it and how is their perception different from the perception of media publicThe project will map innovative journalist practices in the international context in order to identify the examples of good practices and find forms that will be used in the production of innovative media content, which will be tested on focus groups. To that end, the project will develop innovative forms of digital journalism, ways journalists use and transmit information, produce audiovisual content and shape new forms of content presentation using digital tools. Finally, these forms of journalistic expression created through innovative tools will be tested in focus groups and with practicing journalists.]]></summary_en></project><project>
<id>9255</id><title_hr><![CDATA[Šteta, namjere i odgovornost]]></title_hr><title_en><![CDATA[]]></title_en><user_id>2690</user_id><user_firstLast_name>Tvrtko Jolić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-4459</code><acronim><![CDATA[HIRe]]></acronim><duration>10.11.2020 - 09.11.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filozofija, </scie_field_hr><scie_field_en>Philosophy, </scie_field_en><institution_hr><![CDATA[Institut za filozofiju]]></institution_hr><institution_en><![CDATA[Institute for Philosophy in Zagreb]]></institution_en><team_members_id>858392</team_members_id><team_members_names><![CDATA[ Doktorand: Ana Grgić ]]></team_members_names><keywords_hr><![CDATA[Šteta, namjere, odgovornost, smrt, psihopatija, dopustivost, rat]]></keywords_hr><keywords_en><![CDATA[Harm, intentions, responsibility, death, psychopathy, permissibility, war]]></keywords_en><summary_hr><![CDATA[Šteta, namjera i odgovornost središnji su pojmovi oko kojih se odvijaju suvremene rasprave na području etike, političke filozofije i filozofije djelovanja. Naše istraživanje uklapa se u recentne filozofske rasprave koje tematiziraju značenje tih pojmova kao i njihove normativne implikacije u raznim domenama našega svakodnevnoga života. Istraživanje ćemo podijeliti u tri dijela: (1) Priroda štete; (2) Šteta i moralni značaj namjera; te (3) Individualna i kolektivna odgovornost. U posljednjoj fazi istraživanja objedinit ćemo prethodno ostvarene rezultate s namjerom zadobivanja jedinstvene i koherentne slike o tome na koji su način navedeni pojmovi međusobno povezani.]]></summary_hr><summary_en><![CDATA[Harm, intention, and responsibility are the central concepts around which contemporary discussions on ethics, political philosophy and philosophy of action take place. Our research fits into recent philosophical discussions that discuss the meaning of these concepts as well as their normative implications in the various domains of our everyday life. The research will be divided into three parts: (1) The nature of harm; (2) Harm and the moral significance of intentions; and (3) Individual and collective responsibility. In the last phase of the research, we will combine previously achieved results with the aim of obtaining a unique and coherent image of how these notions are related to each other.]]></summary_en></project><project>
<id>9259</id><title_hr><![CDATA[Audio tehnologije u sustavima virtualne stvarnosti za primjenu u auralizaciji]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3404</user_id><user_firstLast_name>Kristian Jambrošić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-1687</code><acronim><![CDATA[AUTAURA]]></acronim><duration>01.10.2020 - 30.09.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>856245</team_members_id><team_members_names><![CDATA[ Doktorand: Vedran Planinec ]]></team_members_names><keywords_hr><![CDATA[auralizacija, audio, virtualna akustika, virtualna stvarnost, binauralna sinteza, praćenje položaja glave]]></keywords_hr><keywords_en><![CDATA[auralisation, audio, virtual acoustics, virtual reality, binaural synthesis, head tracking]]></keywords_en><summary_hr><![CDATA[Auralizacija pronalazi sve više važnih primjena u svakodnevnom životu razvojem i lakom dostupnošću tehnologija i sustava virtualne stvarnosti. Projekt je fokusiran na istraživanje implementacije auralizacije na različitim sustavima, poglavito korištenjem binauralne tehnologije s dodanim sustavom za praćenje položaja glave. Uz dostupne komercijalne VR sustave, ispitati će se mogućnost uporabe povoljnih inercijskih senzora koji se dodaju jednostavnim ugradbenih sustavima kao alternativna inačica sučelja za auralizaciju radi dodavanja slušnog doživljaja u VR primjenama. Dodatno će se ispitati mogućnost korištenja široko rasprostranjenih pametnih telefona sa svojim već integriranim senzorima pokreta i smjera za potrebe auralizacije koristeći binauralnu tehnologiju. Navedeni sustavi izmjeriti će se i usporediti s obzirom na preciznost, latenciju i stabilnost, a ocijeniti će se i kvaliteta doživljaja prirodnosti virtualnog zvučnog polja na praktičnim primjerima auralizacije u laboratorijskom okruženju i u realnoj situaciji na terenu.]]></summary_hr><summary_en><![CDATA[Auralisation finds more and more important applications in everyday life by the development and broad availability of virtual reality technologies and systems. The project is focused on research of auralisation implementation in different systems, mainly by using binaural technology with an added head tracking system. Beside commercially available VR systems, the possibility of using inexpensive inertial measurement sensors added to simple embedded systems will be investigated as an alternative auralisation system for adding aural experience to VR applications. Additionally, the potential of using widely available smartphones with already integrated movement and direction sensors for auralisation purposes using binaural technology will be examined. The precision, stability and latency of the listed hardware platforms will be measured and compared, and the quality of immersion and naturalness of the virtual sound field in practical auralisation examples will be evaluated, both in laboratory and in-situ conditions.]]></summary_en></project><project>
<id>9261</id><title_hr><![CDATA[Renesansa teorije uzorkovanja]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6982</user_id><user_firstLast_name>Damir Seršić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-8418</code><acronim><![CDATA[SamplingRenaissance]]></acronim><duration>01.10.2020 - 30.09.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>858332</team_members_id><team_members_names><![CDATA[ Doktorand: Tomislav Matulić ]]></team_members_names><keywords_hr><![CDATA[post-uzorkovanje, sažimajuće očitavanje, hibridni podatkovni modeli, hibridne metode obrade, svjetlosno polje, 3D rekonstrukcija, PET]]></keywords_hr><keywords_en><![CDATA[post-sampling, compressive sensing, hybrid data models, hybrid processing methods, light field, 3D reconstruction, PET]]></keywords_en><summary_hr><![CDATA[Uzorkovanje i rekonstrukcija signala sačinjavaju središnji dio digitalne obrade signala (DSP). Teorem uzorkovanja predstavlja vezu između kontinuiranog i diskretnog svijeta u modernim elektroničkim uređajima, pametnim telefonima, kamerama te medicinskoj opremi. Sažimajuće očitavanje (CS) tehnika je koja se oslanja na konačnu frekvenciju inovacije kako bi se smanjio broj mjerenja potrebnih za statistički pouzdanu rekonstrukciju.  Brz napredak u ovom području istraživanja predstavlja renesansu teorije uzorkovanja, prvenstveno zbog svog značaja za znanstvenu zajednicu koja se bavi digitalnom obradom signala.Naše istraživanje doprinosi ovom izazovnom području u nekoliko aspekata. Nova paradigma post-uzorkovanja temeljit će se na hibridnim kontinuirano-diskretnim modelima podataka i metodama obrade. Navedeno će omogućiti kontinuiranu obradu signala na digitalnom računalu bez diskretnih aproksimacija temeljenih na uzorcima. Osim toga, uvest će se novi optimalni i adaptivni pristupi mjerenju. Kako bi se prevladali određeni nedostaci redukcije dimenzionalnosti u sažimajućem očitavanju, uvest će se eksploratorna mjerenja.U novije vrijeme pristup temeljen na dubokom učenju rezultirao je brzim napretkom metoda nadziranog učenja. Stoga ćemo primijeniti metode strojnog učenja kako bismo postigli visoku kvalitetu i brzu CS rekonstrukciju signala. Rezultati našeg istraživanja donijet će poboljšanja u praktičnim primjenama kao što su snimanje iz višestrukih pogleda, snimanje svjetlosnog polja, 3D rekonstrukcija te medicinsko snimanje, odnosno pozitronska emisijska tomografija (PET). Snimanje svjetlosnog polja nadilazi mogućnosti klasične fotografije te omogućuje naknadnu obradu slika, primjerice promjenu gledišta, digitalno refokusiranje te virtualnu promjenu otvora blende. Korištenjem slika iz višestrukih pogleda, slika svjetlosnog polja te PET slika, naše istraživanje omogućit će točniju 3D rekonstrukciju.]]></summary_hr><summary_en><![CDATA[Signal sampling and reconstruction are a central part of the digital signal processing (DSP) - the sampling theorem provides a bridge between the continuous and discrete-time world in modern electronic devices, smartphones, cameras and medical equipment. Compressive sensing (CS) is a technique that relies on finite rate of innovation in order to reduce the number of measurements needed for statistically reliable reconstruction. Rapid advances in this research area bring a renaissance of the sampling theory, mostly due to its significance to the DSP community. Our research contributes to this challenging field in several aspects. New post-sampling paradigm will be based on hybrid continuous-discrete data models and processing methods. It will enable continuous signal processing on a digital computer without the discrete approximation based on samples. Moreover, novel optimal and adaptive measurement approaches will be introduced. Exploratory measurements will be proposed to overcome certain drawbacks of the CS dimensionality reduction. Recently, a deep learning based approach resulted in a rapid advance of supervised learning methods. We will apply machine learning methods to achieve high quality and fast CS reconstruction. Applications that will benefit from our research results are multi-view and light field imaging, 3D reconstruction and medical imaging, namely positron emission tomography (PET). Light field imaging goes beyond the conventional photography and enables powerful post-capture capabilities, such as change of viewpoint, digital refocusing, and virtual change of aperture. Our research will enable more accurate 3D reconstruction from multi-view, light field and PET images.]]></summary_en></project><project>
<id>9266</id><title_hr><![CDATA[Creating Mechanisms for Continuous Implementation of the Sports Club for Health Guidelines In the European Union (SCforH)]]></title_hr><title_en><![CDATA[]]></title_en><user_id>2938</user_id><user_firstLast_name>Danijel  Jurakić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-8078</code><acronim><![CDATA[]]></acronim><duration>12.10.2020 - 11.10.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Kineziologija, </scie_field_hr><scie_field_en>Kinesiology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Kineziološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Kinesiology]]></institution_en><team_members_id>861737</team_members_id><team_members_names><![CDATA[ Doktorand: Tena Matolić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>9269</id><title_hr><![CDATA[Izračun antropometrijskih mjera pametnim telefonom i tabletom]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6641</user_id><user_firstLast_name>Tomislav Petković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-5587</code><acronim><![CDATA[STEAM]]></acronim><duration>01.10.2020 - 31.12.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>861754</team_members_id><team_members_names><![CDATA[ Doktorand: David Bojanić ]]></team_members_names><keywords_hr><![CDATA[3D skeniranja tijela, antropometrija, 3D antropometrijski podaci, ljudska postura, karakteristične točke tijela, tablet,pametni telefon, računalni vid]]></keywords_hr><keywords_en><![CDATA[3D body scan measurement, anthropometry, 3D anthropometric data, human posture, body landmark detection, tablet, smartphone, computer vision]]></keywords_en><summary_hr><![CDATA[Izrada 3D modela iz fotografija je jedna od glavnih zadaća računalnog vida, grane umjetne inteligencije u području računalne znanosti koja istražuje metodologiju izdvajanja informacija iz digitalnih slika. Dobivanje kvalitetnih 3D modela više nije ograničeno na obradu i istraživanje korištenjem stolnih računala i/ili prijenosnih računala visokih performansi. Moderni i moćni pametni telefoni te tableti (mobilne platforme) također otvaraju mogućnosti definiranja novih metoda za 3D rekonstrukciju. Dotično istraživanje ima dva glavna dijela. Prvi dio odnosi se na razvoj i implementaciju učinkovitih 3D algoritama rekonstrukcije optimiranih za posebnosti mobilnih platformi. Proširivanje funkcionalnosti pametnog telefona ili tableta prema 3D uređaju za skeniranje je značajno ne samo s gledišta znanstvenog istraživanja već i za potencijalnu industrijsku primjenu (ekonomsko iskorištavanje). Stoga je drugi dio ovog rada usmjeren na procjenu antropometrijskih veličina uporabom 2D i 3D podataka s mobilnih platformi. Antropometrijska mjerenja su od velikog značaja širokoj skupini korisnika jer antropometrija danas igra važnu ulogu u industrijskom dizajnu, dizajnu odjeće, ergonomiji, medicini i arhitekturi gdje se statistički podaci o raspodjeli dimenzija tijela u populaciji koriste za optimizaciju različitih proizvoda i usluga.]]></summary_hr><summary_en><![CDATA[The generation of 3D models from still images has been a long term goal in computer vision, a branch of artificial intelligence in the field of computer science which explores the state machines and models for extracting information from the digital images. Acquiring high quality 3D models is no longer restricted to processing on desktop computers and high end laptops. Modern and powerful smartphones and tablets (mobile platforms) open up the possibilities designing new methods for 3D reconstruction. The scope of this work is twofold. First part concerns the development and implementation of the efficient 3D reconstruction algorithms optimized for the mobile platforms features. Extending smartphone or tablet functionality towards 3D scanning device is interesting both for the scientific research and for the industrial (economic) exploitation as well. Therefore, the second part of this work is aimed at estimation of anthropometric measurements combining 2D and 3D data from mobile platforms. Anthropometric measurements are of particular interest to a large group of beneficiaries since nowadays anthropometry plays an important role in industrial design, clothing design, ergonomics, medicine and architecture where statistical data about the distribution of body dimensions in the population are used to optimize various products and services.]]></summary_en></project><project>
<id>9270</id><title_hr><![CDATA[Stanična parabioza: uloga međustanične komunikacije u fenotipskoj supresiji]]></title_hr><title_en><![CDATA[]]></title_en><user_id>12479</user_id><user_firstLast_name>Katarina Vukojević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-1998</code><acronim><![CDATA[]]></acronim><duration>12.07.2021 - 12.11.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Mediteranski institut za istraživanje života, Split]]></institution_hr><institution_en><![CDATA[Mediterranean Institute for Life Sciences, Split]]></institution_en><team_members_id>865059</team_members_id><team_members_names><![CDATA[ Doktorand: Nikola Pavlović ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>9271</id><title_hr><![CDATA[Doprinos religijskog obrazovanja suživotu u multikulturalnome društvu]]></title_hr><title_en><![CDATA[]]></title_en><user_id>26133</user_id><user_firstLast_name>Ružica Razum</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-7310</code><acronim><![CDATA[RELIGOBRAZ]]></acronim><duration>01.08.2020 - 31.01.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Teologija, </scie_field_hr><scie_field_en>Theology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Katolički bogoslovni fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Catholic Faculty of Theology]]></institution_en><team_members_id>855681</team_members_id><team_members_names><![CDATA[ Doktorand: Marija  Jurišić ]]></team_members_names><keywords_hr><![CDATA[religijsko obrazovanje, hrvatski odgojnoobrazovni sustav, odgoj za suživot, interkulturalnost, nastavničke kompetencije]]></keywords_hr><keywords_en><![CDATA[religious education, Croatian educational system, education to coexistence, interculturality, teaching competences]]></keywords_en><summary_hr><![CDATA[U istraživačkome žarištu projekta nalazi se pojava multikulturalnih društvenih struktura koje mijenjaju odnose među ljudima te otvaraju za odgoj i obrazovanje mnoga pitanja. Hrvatska, kao dio europskoga prostora, suočena je sa sve većim razvojem komunikacijskih tehnologija, globalizacijom, migracijskim procesom i izbjegličkom krizom. Osim toga, Hrvatska ima veoma poseban geografsko-povijesni položaj. Nadalje, živi u konfliktnom postratnom kontekstu opterećenom bolnim ratnim iskustvima čije posljedice dodatno otežavaju suživot. Svi ti čimbenici i procesi zahtijevaju interkulturalni odgojno-obrazovni napor (naučiti živjeti zajedno), koji nužno uključuje i religijsku dimenziju kao bitan element kulture. Školi pripada osobito važno mjesto i odgovornost za promicanje dijaloga, nužnog preduvjeta mira i suživota.Cilj je projekta istražiti doprinos religijskoga obrazovanja u školama u Hrvatskoj odgoju i obrazovanju za suživot u multikulturanome društvu. Taj će se doprinos istražiti na dvije razine: na razini kurikuluma predmeta koji posreduju religijska znanja u osnovnoj i u srednjoj školi; na razini interkulturalnih kompetencija samih nastavnika. Istraživanje uključuje analizu dokumenata važnih za razumijevanje interkulturalnog i međureligijskog odgoja i obrazovanja. Nadalje, uključuje komparativnu analizu kurikuluma konfesionalnoga religijskoga obrazovanja u osam europskih zemalja s ciljem da se upoznaju temeljni interkulturalni / međureligijski ciljevi i sadržaji. Predmet istraživanja su također kurikulumi katoličkog, pravoslavnog i islamskog vjeronauka u RH. Predmet istraživanja su isto tako predmeti i međupredmetne teme koji posreduju religijsko znanje kao dio interkulturalnoga odgoja i obrazovanja. Unutar istraživanja provest će se i empirijsko istraživanje o stavovima nastavnika o međureligijskome obrazovanju u katoličkoj, pravoslavnoj i islamskoj vjeronaučnoj nastavi. Provest će se i analiza studijskih programa koji osposobljavaju buduće nastavnike vjeronauka.]]></summary_hr><summary_en><![CDATA[In the research focus of this project is the appearance of multicultural social structures that change the relations between people and open up many questions for education. Croatia has a very specific geographic-historical position. Through centuries of existence at the intersection of a number of various cultures and religions, Croatia has been strongly marked by a variety of complex historical, socio-cultural, and religious features. Furthermore, Croatia lives in a conflict post-war context burdened with extremely painful war experiences with consequences that additionally complicate coexistence. All those factors and processes required an intercultural educational effort, which necessarily includes the religious dimension as a significant element of culture.The objective of this project is to investigate the contribution of religious education in elementary and secondary schools in Croatia to the education for coexistence in modern multicultural society. That contribution will be investigated at two levels: at the level of curricula of school subjects that mediate religious knowledge in elementary and secondary schools; at the level of competences of teachers on whom the promotion of intercultural/interreligious education depends the most. Research includes an analysis of fundamental European, Croatian, and documents of the Catholic Church significant for understanding intercultural and interreligious education. Furthermore, it includes a comparative analysis of the curricula of confessional religious education in 8 European countries. An object of this research is also the new curricula of Catholic, Orthodox, and Islamic religious education in Croatia. An object of this research is also school subjects and inter-curricular subjects that are part of the social-humanistic area. Empirical research will also be conducted within this research, with the objective of investigating attitudes of teachers about the interreligious dialogue.]]></summary_en></project><project>
<id>9272</id><title_hr><![CDATA[Razvoj funkcionalnih biogoriva i (bio)aditiva te ispitivanje primjenskih svojstava mješavina s mineralnim gorivima]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1337</user_id><user_firstLast_name>Fabio Faraguna</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-1623</code><acronim><![CDATA[FunBioFA]]></acronim><duration>27.10.2020 - 15.04.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Kemijsko inženjerstvo, </scie_field_hr><scie_field_en>Chemical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet kemijskog inženjerstva i tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Chemical Engineering and Technology]]></institution_en><team_members_id>858335</team_members_id><team_members_names><![CDATA[ Doktorand: Ivan Pucko ]]></team_members_names><keywords_hr><![CDATA[Biogorivo, Bioaditiv, Membransko pročišćavanje, Motorni test, Ispušni plinovi, Mješavine goriva i biogoriva, Karakterizacija goriva, EN 590, EN 228, E]]></keywords_hr><keywords_en><![CDATA[Biofuel, Bioadditives, Membrane purification, Engine combustion tests, Exhaust gas, Fuel and Biofuel blends, Fuel characterization, EN 590, EN 228, EN]]></keywords_en><summary_hr><![CDATA[Fosilna goriva kao primarni izvori energije imaju značajan utjecaj na okoliš i pridonose globalnom zatopljenju. U okvirima svjetske klimatsko-energetske politike teži se zamjeni upotrebe fosilnih goriva s obnovljivim izvorima energije kao što su biomasa, sunce, vjetar i geotermalna energija. Trenutno je biomasa četvrti najzastupljeniji energetski resurs na svijetu, odmah nakon nafte, plina i ugljena. Biomasa se može pretvoriti u sve glavne energetske nositelje (npr. električna struja, toplina) kao i široku paletu kemikalija i materijala koji se trenutno proizvode iz fosilnih goriva. Sinergija perspektive znanosti i industrije u stvaranju inovativnih novih materijala na bio-osnovi, kao što su funkcionalna biogoriva i bioaditivi, ključni je korak za učinkoviti prijelaz iz trenutnog razdoblja, gdje su fosilni izvori osnova energije i kemikalija, u razdoblje biogoriva i biokemikalija iz obnovljivih izvora. U ovom projektu razvit će se nova funkcionalna biogoriva, bioaditivi i polimerni aditivi te osmisliti nove i unaprijediti postojeće metode pročišćavanja biokemikalija membranskim procesima. Ispitat će se primjenska svojstva dvokomponentnih (mineralno gorivo, biogorivo), trokomponentnih (mineralno gorivo, biogorivo, alkohol) i formuliranih mješavina s (bio)aditivima prema standardima i normama za goriva i biogoriva. Nakon analiza sljedit će ispitivanje karakteristika izgaranja u motoru te analiza ispušnih plinova. Cilj ovog projekta je od otpadne sirovine (otpadno ulje, životinjska mast) primjenom kemijskih i kemijsko inženjerskih znanja razviti proces sinteze/pročišćavanja koji će za produkt imati visokovrijednu biokemikaliju u obliku funkcionalnog biogoriva ili bioaditiva. Za vrijeme trajanja projekta, troje mladih znanstvenika (dvoje iz naftne industrije) steći će napredna znanja u području sinteze, pročišćavanja i analize biogoriva i bioaditiva što će moći primijeniti izravno u industriji tokom razvoja novih procesa i proizvoda.]]></summary_hr><summary_en><![CDATA[Fossil fuels as primary sources of energy have a significant impact on the environment and contribute to global warming. Within the framework of the global climate and energy policy, the replacement of fossil fuels with renewable energy sources such as biomass, solar, wind and geothermal energy is sought. At present, biomass, immediately after oil, gas and coal, is the fourth most abundant energy resource in the world. Biomass can be converted into all major energy carriers (e.g. electricity, heat) as well as a wide diversity of chemicals and materials that are currently produced from fossil fuels. In the field of sustainable energy, combining science and industry perspectives to create innovative new biobased materials, like functional biofuels and bioadditives, is critical to efficiently cope with the current period of transition from fossil based energy, chemicals and materials, to renewable energy, biochemicals and biomaterials. During this project, new functional biofuels, bioadditives and polymer additives will be developed and their purification using membrane process will be investigated. Application properties (according to standards for fuels and biofuels) of new biofuels, two-component (mineral fuel, biofuel), three-component (mineral fuel, biofuel, alcohol) blends and formulated mixtures with (bio)additives will be determined as well as their engine combustion characteristics and exhaust gas analysis. The aim of this project is to develop a synthesis / purification process which will produce a high value biochemical in the form of a functional biofuel or a bioadditive from waste material (waste oil, animal fat), using chemical and chemical engineering expertise. During the project, three young scientists (two from the industry) will acquire advanced knowledge in the field of synthesis, purification and analysis of biofuels and bioadditives, which they will be able to apply directly for development of new processes and products in the industry.]]></summary_en></project><project>
<id>9273</id><title_hr><![CDATA[Racionalan dizajn prirodnih eutektičkih otapala za pripremu i formulaciju kiralnih lijekova  ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6126</user_id><user_firstLast_name>Marina Cvjetko Bubalo</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-4728</code><acronim><![CDATA[NADESChiralDrug]]></acronim><duration>19.10.2020 - 18.04.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Biotehnologija, </scie_field_hr><scie_field_en>Biotechnology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Food Technology and Biotechnology]]></institution_en><team_members_id>857311</team_members_id><team_members_names><![CDATA[ Doktorand: Mia Radovic Radovic ]]></team_members_names><keywords_hr><![CDATA[biokataliza, kiralni sintoni, NADES, zelena otapala, THEDES]]></keywords_hr><keywords_en><![CDATA[biocatalysis, chiral synthon, NADES, green solvents , THEDES]]></keywords_en><summary_hr><![CDATA[Moderna kemijska i farmaceutska industrija zahtjeva visoki stupanj enantiomerne čistoće biološki aktivnih kiralnih spojeva stoga se razvijaju različite metode za proizvodnju i formulaciju kiralnih lijekova. Uvidom u suvremenu literaturu očituje se sve veći interes za nove i ekološki prihvatljive pristupe u pripravi i formulaciji kiralnih lijekova: primjena prirodnih eutektičkih otapala (NADES) kao medija za njihovu pripravu ili kao pomoćnog sredstva za isporuku kiralnog lijeka kroz sintezu terapeutskih eutektičkih otapala (THEDES). Međutim, unatoč obećavajućim rezultatima primjene ovih otapala, dosadašnja potraga za idealnim NADES za određeni reakcijski sustav vođena je empirijskim pristupom pokušaja i pogrešaka, pri čemu je sistematsko istraživanje odnosa struktura-aktivnoststruktura-aktivnost NADES, kao okosnice racionalnog dizajna ovih otapala za specifične namjene, još uvijek u povojima. To je izravna posljedica nedostatka temeljnih znanja o ovim otpalima, a što onemogućava potpuno razumijevanje njihove mehanističke uloge u raznim biotehnološkim procesima. Stoga, prikupljanje podataka o osnovnim svojstvima NADES te razvoj matematičkih metoda kao alata za dizajniranje otapala s optimalnim svojstvima predstavlja imperativ za njihovu industrijsku primjenu. Na temelju navedenog, glavni cilj predloženog multidisciplinarnog Projekta jest stjecanje znanja o NADES te istraživanje prednosti njihove primjene u zelenom pristupu priprave i formulacije kiralnih lijekova. Kako bi ostvarili zadane ciljeve projekta, definirani su sljedeći specifični ciljevi: (1) racionalni dizajn NADES za pripravu i formulaciju kiralnog lijeka (2) implementacija NADES u enzimski kataliziranoj pripravi intermedijera kiralnog lijeka (3) razvoj THEDES kao poboljšane formulacije kiralnog lijeka. Ovo multidisciplinarno istraživanje koje uključuje organske kemičare, biotehnologe i farmaceute bilo bi dokaz koncepta NADES kao otapala/pomoćne tvari u pripravi i formulaciji enantiomerno čistih lijekova.]]></summary_hr><summary_en><![CDATA[Nowadays, single-enantiomer drugs have become the standard in pharmaceutical companies when working with compounds featuring stereogenic centers, mobilizing chemical and biotechnological industry to develop versatile methods for production and formulation of biologically active chiral compounds of high enantiomeric purity. Overview of current literature on chiral drug production and formulation reveals exciting, new and green approach: the use of natural deep eutectic solvents (NADES) as medium for biotechnological preparation of chiral biologically active compounds and as auxiliaries in development of chiral drug delivery system through designing therapeutic deep eutectic solvents (TEHDES). However, this exciting research field still faces several great challenges. Namely, approaches used so far for screening ideal NADES have been governed by time consuming empirical methods, while systematic investigation in NADES structure-activity relationship, as a backbone for rational design of these solvents, is still lacking. Extension of fundamental research on NADES solvent properties, as well as development of mathematical models as tools for designing ideal NADES for specific purpose becomes an imperative for industrial use of NADES. Based on the stated above the aim of proposed Project is to is to demonstrate the advantages of using NADES as green approach in the biotechnological preparation and formulation of chiral drugs. To achieve Project goals, specific objectives of the Project are, therefore, the following: (1) rational design of NADES for chiral drug preparation and formulation (2) implementation of NADES in enyzme-catalyzed preparation of chiral drug intermediates (3) development of THEDES as improved formulation of chiral drug. This multidisciplinary research which includes chemists, biotechnologists and pharmacist would be our proof-of-concept of the NADES promising use as solvents/auxiliaries in enantiopure drug preparation and formulation. ]]></summary_en></project><project>
<id>9274</id><title_hr><![CDATA[Endocitoza adenovirusa i urođeni imunosni odgovor]]></title_hr><title_en><![CDATA[]]></title_en><user_id>12819</user_id><user_firstLast_name>Dragomira Majhen</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-6596</code><acronim><![CDATA[AdenoIN]]></acronim><duration></duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>856291</team_members_id><team_members_names><![CDATA[ Doktorand: Isabela Pehar ]]></team_members_names><keywords_hr><![CDATA[adenovirus tipa 26, vektorsko cjepivo, integrin, endocitoza, urođeni imunitet]]></keywords_hr><keywords_en><![CDATA[adenovirus type 26, vector vaccine, integrin, endocytosis, innate immunity]]></keywords_en><summary_hr><![CDATA[Vektorska cjepiva na bazi adenovirusa tipa 26 (HAdV26) istražuju se u 28 kliničkih ispitivanja, od kojih je nekoliko u fazi III. Dok je in vivo imunogenost HAdV26 prilično dobro opisana, osnovna biologija ovog virusa je još uvijek nedovoljno shvaćena. Nedavno smo pokazali da je avß3 integrin potreban za uspješnu infekciju epitelnih stanica s HAdV26, no nedostaju istraživanja vezana uz urođeni imunosni odgovor potaknut infekcijom epitelnih stanica s HAdV26 te endocitozu ovog virusa. Na temelju naših preliminarnih podataka pretpostavljamo da bi izmijenjena endocitoza HAdV26 zbog vezanja avß3 integrina ili smanjenog klatrina mogla potaknuti različit imunosni odgovora domaćina, te tako utjecati na uspješnost vektora baziranog na HAdV26. Cilj AdenoIN-a je istražiti urođeni imunosni odgovor potaknut infekcijom epitelnih stanica s HAdV26 u kontekstu upotrebe avß3 integrina kao receptora i/ili izmijenjene endocitoze virusa zbog smanjene količine klatrina. Stoga ćemo u stanicama s povećanom ekspresijom avß3 integrina i/ili smanjenom količinom klatrina nakon infekcije s HAdV26 koristeći metode western blot, ELISA, konfokalna mikroskopija i PCR čip: i) proučavati endocitozu fluorescentno obilježenog HAdV26, ii) profilirati gene povezane s urođenim imunitetom i inflamasomom, iii) analizirati identificirane proteine od interesa. Ukupni rezultat AdenoIN-a bit će sveobuhvatna analiza avß3 integrinom i klatrinom posredovane endocitoze HAdV26 i time potaknutog urođenog imuniteta u epitelnim stanicama. Dobiveni podaci omogućit će daljnja poboljšanja vektora za prijenos gena i cijepljenje temeljenih na HAdV26, te će tako privući interes ne samo akademskih kolega koji istražuju isto područje, nego i dionika iz industrije. Znanje i iskustvo stečeno u okviru AdenoIN-a, kao i novozaposleni doktorand i poslijedoktorand, omogućit će jačanje i daljnji razvoj nedavno uspostavljene istraživačke grupe za proučavanje adenovirusnih vektora koju na IRB-u vodi prijaviteljica ovog projekta.]]></summary_hr><summary_en><![CDATA[Vaccine vectors based on low seroprevalent adenovirus type 26 (HAdV26) are listed as intervention in 28 clinical trials, among which several in phase III. While HAdV26 immunogenicity in vivo is rather well described, basic biology of this virus is still insufficiently understood. Recently we reported avß3 integrin as a receptor required for HAdV26 successful infection of epithelial cells, however studies regarding HAdV26 endocytosis and innate immunity induced by HAdV26 infection of epithelial cells are missing. Based on our preliminary data we hypothesize that altered HAdV26 endocytosis due to binding avß3 integrin or downregulating clathrin, could lead to induction of different host innate immune response, hence influence performance of HAdV26-based vector. Therefore, the goal of AdenoIN is to address clear gap in understanding the innate immune response induced by HAdV26 infection of epithelial cells in the context of using avß3 integrin as a receptor and/or altered virus endocytosis due to lack of clathrin. Thus, in mock and HAdV26 infected cells with increased expression of avß3 integrin and/or downregulated or inhibited clathrin we will i) study endocytosis of fluorescently labeled HAdV26 by confocal microscopy, ii) profile innate immunity and inflammasome related genes by PCR array, iii) analyze identified proteins of interest by western blot, ELISA, confocal microscopy. Final output of AdenoIN will be comprehensive analysis of avß3 integrin and clathrin mediated HAdV26 endocytosis and subsequent innate immune signaling in epithelial cells. Those data will be valuable for further improvement of HAdV26-based vectors, hence will attract interest not only of academic peers, but also stakeholders from the industry. Knowledge acquired within AdenoIN as well as newly employed doctoral and postdoctoral students will enable strengthening and further development of recently established research group for studying adenovirus vectors led at RBI by PI of this project. ]]></summary_en></project><project>
<id>9275</id><title_hr><![CDATA[Severe weather over the Alpine-Adriatic region in a changing climate (SWALDRIC, IZHRZO-180587)]]></title_hr><title_en><![CDATA[]]></title_en><user_id>11142</user_id><user_firstLast_name>Maja  Telišman Prtenjak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-6990</code><acronim><![CDATA[]]></acronim><duration>07.01.2021 - 06.01.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Interdisciplinarne prirodne znanosti, </scie_field_hr><scie_field_en>Interdisciplinary natural sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>861747</team_members_id><team_members_names><![CDATA[ Doktorand: Branimir Omazić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>9277</id><title_hr><![CDATA[MOLEKULARNI MEHANIZMI TOKSIČNOSTI PROTUOTROVA I POTENCIJALNIH LIJEKOVA]]></title_hr><title_en><![CDATA[]]></title_en><user_id>982</user_id><user_firstLast_name>Maja Katalinić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-3928</code><acronim><![CDATA[CellToxTargets]]></acronim><duration>01.10.2020 - 31.12.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut za medicinska istraživanja i medicinu rada]]></institution_hr><institution_en><![CDATA[Institute for Medical Research and Occupational Health]]></institution_en><team_members_id>858373</team_members_id><team_members_names><![CDATA[ Doktorand: Ana-Marija Lulić ]]></team_members_names><keywords_hr><![CDATA[antidoti, organofosforni spojevi, stanice, enzimi, nuspojave]]></keywords_hr><keywords_en><![CDATA[antidotes, organophosphorus compounds, cells, enzymes, side-effects]]></keywords_en><summary_hr><![CDATA[Predloženi projekt predstavlja nov i inovativan pristup u istraživanju protuotrova organofosfornim spojevima (OP), s potencijalom opće primjene u području dizajna novih lijekova. Glavni cilj predloženog projekta je odgovoriti na pitanje kako protuotrovi i potencijalni lijekovi djeluju na staničnoj razini te otkriti mehanizme okidače za neželjene učinke ili nuspojave in vivo. Kako bi se utvrdio mehanizam koji stoji iza takve toksičnosti spojeva i kako bi se potpomognula učinkovitija selekcija kandidata za razvoj lijeka, primijenit će se specifični pretklinički probir temeljen na staničnim testovima. Unutar predloženog projekta ispitat ćemo nekoliko strukturno povezanih setova spojeva. Po dobivanju rezultata istraživanja, moći ćemo primijeniti pristup analize strukture i aktivnosti kako bismo odredili moguće strukturne značajke ispitanih spojeva odgovorne za određene učinke. Tako se značajke poput tih mogu modificirati u ranoj fazi poboljšanja strukture vodećeg spoja bez provođenja ikakvih studija in vivo. To će omogućiti i učinkovitije povratne informacije istraživačima koji rade na oblikovanju npr. protuotrova i doprinijeti razvoju djelotvornije terapije za trovanje OP spojevima. Očekujemo i identifikaciju novih farmakoloških meta na staničnoj razini, kao i mogućnost istraživanja njihovog terapijskog potencijala. Jedna takva meta kod tretmana trovanja OP-ovima, koja je identificirana u našem istraživanju, je novi enzim NRE. Stoga ćemo ispitati ulogu i funkciju ovog enzima i odgovoriti bi li se isti mogao razmatrati kao ciljna molekula u liječenju otrovanja OP-ima ili bi mogao imati indikaciju u liječenju drugih stanja i bolesti. Ovi bi rezultati otvorili i novu perspektivu s utjecajem koji nadilazi prvotno polje primjene. Uz ovaj znanstveni dio, iskusni i kvalificirani istraživački tim nastavit će poticati prijenos tehnologije putem raznih suradnji, kontinuirane nadogradnje i unaprjeđenja metoda te osposobljavanjem u području specifičnih vještina.]]></summary_hr><summary_en><![CDATA[The project presents the new innovative approach in the field of antidote research for poisoning with organophosphates (OP), having the applications in overall drug discovery. The main goal of the project is to answer how the antidotes and drugs act on cell level and uncover the trigger mechanism leading to the side-effects or even severe effects that could occur in vivo. The specific cell-based screening will be applied to define the mechanism behind such unwanted toxicity of compounds and to aid a more efficient selection of a lead candidate for drug development. Within the proposed project, we will test several defined sets of structurally related antidotes/drugs. This will allow us to use, after obtaining sufficient cell-based data, a structure-activity approach to define the possible structural features of tested compounds triggering certain effects. Thus, features like these could be modified in the early lead compound structure refinement process without performing any in vivo studies. More efficient feedback will be given to studies designing drugs and aid the challenging development of an effective treatment primarily for OP poisoning. We also expect to identify new possible targets on the cell level and explore their therapeutic potential. One such target in treating exposure to OPs, NRE, was identified in our earlier research. Therefore, we will study the role and function of this unexplored enzyme and answer whether it could be considered as a potential target in OP treatment or even has an indication for being a target molecule in treatment of other diseases. Our findings should open up a new perspective with potential impact beyond the original scope. Beside the scientific part, the newly established experienced and skilled research team will stimulate a technology transfer through collaborations, continuous upgrading and improvement of methods and training in specific skills.]]></summary_en></project><project>
<id>9278</id><title_hr><![CDATA[Jednoslojni polarimetar gama zračenja za primjene u medicinskom oslikavanju i za temeljna istraživanja u fizici]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1479</user_id><user_firstLast_name>Mihael Makek</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-4393</code><acronim><![CDATA[SiLGaP]]></acronim><duration>28.04.2021 - 27.04.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>864949</team_members_id><team_members_names><![CDATA[ Doktorand: Om prakash Dash ]]></team_members_names><keywords_hr><![CDATA[Scintilacijski detektori, polarizacija gama zračenja, komptonsko oslikavanje, pozitronska emisijska tomografija, kvantna sprega]]></keywords_hr><keywords_en><![CDATA[Scintillation detectors, Gamma polarization, Compton imaging, Positron emission tomography, Quantum entanglement]]></keywords_en><summary_hr><![CDATA[Informacija o polarizaciji gama zračenja je važna u mnogim područjima suvremenih istraživanja u fizici. U području fundamentalnih istraživanja primjer je fenomen kvantne sprege, kojeg je moguće proučavati analiziranjem relativnih polarizacija tri gama fotona iz raspada orto-pozitronija. U području primjena, važan je slučaj biomedicinsko oslikavanje pomoću pozitronske emisijske tomografije (PET), gdje su simulacijske studije pokazale da polarizacijska informacija, koje se ne koristi u dostupnim PET sustavima, ima potencijal poboljšati kvalitetu slike. Polarizacija gama fotona se može odrediti putem Comptonova raspršenja, koje rezultira rapršenim elektronom i raspršenom gama česticom.  Za rekonstrukciju Comtponovih raspršenja potrebni su pozicijski i energijski osjetljivi detektori, koji se obično sastoje od dva sloja, prvog za detekciju elektrona i drugog za detekciju raspšenog fotona. No, u mnogim primjenama gdje su detektori izrazito segmentirani i sadrže velik broj kanala, kao u PET-u, sustav utemeljen na dvoslojnim detektorima imao bi relativno visoku cijenu. U ovom projektu napravit ćemo novi, modularni sustav za mjerenje polarizacije gama fotona, utemeljen na jednoslojnim detektorima za mjerenje Comptonova raspšrenja. Pojedini modul će se sastojati od matrice scintilacijskih detektora, iščitavanih silicijskim fotomultiplikatorima. U usporedbi sa dvoslojnim sustavima, ovaj koncept nudi mogućnost konstrukcije cjenovno povoljnijih, kompaktnih i višenamjenskih uređaja.  U projektu ćemo postaviti sustav od šesnaest modula, koji će se primijeniti u dva istraživanja. U prvom će se po prvi put eksperimentalno ispitati mogućnost korištenja informacija o polarizaciji gama zračenja u PETu, kao važan korak prema novoj generaciji efikasnijih uređaja za medicinsko oslikavanje. U drugom će analizirati azimutalne korelacije tri gama fotona iz raspada orto-pozitronija, da bi se istražila kvantna sprega, kao temeljni fizikalni koncept.]]></summary_hr><summary_en><![CDATA[Gamma-ray polarization information is valuable in many areas of contemporary physics research. An example in fundamental sector is the phenomenon of quantum entanglement, which may be investigated by analyzing relative polarizations of three gammas originating from ortho-positronium decay. In applications, an important case is the biomedical imaging with Positron Emission Tomography (PET), where it has been shown by simulated model studies, that the polarization information, which is not exploited in existing PET systems, has the potential to improve the image quality. The polarization of a gamma photon can be determined from its Compton scattering, where it produces a recoil electron and a scattered photon. For reconstruction of Compton events, one needs position and energy-sensitive detectors, usually encompassing two layers, for detection of the electron and the scattered photon, respectively. However, in many applications where detectors are highly granular and contain many channels, such as PET, a system based on two-layer readout would be costly.  In this project we will construct a new, modular detector system for gamma polarization measurements, based on single-layer Compton scattering detectors. A module will contain an array of scintillators, read-out by silicon photomultipliers. Compared to two-layer detectors, the single-layer concept offers a possibility to construct more cost-efficient, compact and versatile devices. We will assemble a sixteen-module system, which will be used in two applications: first, to evaluate experimentally for the first time the feasibility of using the information about gamma-ray polarization in PET, as an important step towards the next generation of more efficient medical imaging devices, and second, to analyze the azimuthal correlations of three gammas from ortho-positronium decay in order to investigate entanglement as a fundamental concept of quantum physics.]]></summary_en></project><project>
<id>9279</id><title_hr><![CDATA[Uloga RNA vezujućeg proteina CELF 1 u neuronalnom razvoju čovjeka]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5534</user_id><user_firstLast_name>Zeljka Krsnik</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-5029</code><acronim><![CDATA[CELF1NeuDev]]></acronim><duration>01.11.2020 - 01.11.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>861731</team_members_id><team_members_names><![CDATA[ Doktorand: Alisa Junaković ]]></team_members_names><keywords_hr><![CDATA[cerebral cortex, mRNA translation, polysome, transcriptome, human iPSCs, neural progenitor cells (NPCs), induced neurons (iNs)]]></keywords_hr><keywords_en><![CDATA[moždana kora, mRNA translacija, polisomi, transkriptom, ljudske iPSC, neuralne progenitorske stanice, inducirani neuroni]]></keywords_en><summary_hr><![CDATA[Vremenski i prostorno precizno koordiniran izražaj gena preduvjet je normalnog razvoja mozga. Za razliku od regulacije transkripcije koja se desetljećima proučavala, tek je nedavno pokazana važnost regulacije sinteze proteina tijekom razvoja mozga miša. Grupa prof. Rašina sa Sveučilišta Rutgers je nedavno pokazala na mišjem modelu kako se mRNA molekule najprije prepisuju, a nakon toga čekaju signal za translaciju u proteine, pri čemu ključnu ulogu imaju RNA-vezujući proteini (engl. RNA-binding proteins, RBP). Jedan od tih proteina, Celf1, potreban je za razvoj progenitorskih stanica i glutamatergičkih neurona tijekom razvoja moždane kore miša. Unatoč impresivnom napretku u saznanju važne uloge mRNA translacije u regulaciji razvoja moždane kore miša posljednjih godina, niz pitanja ostaje otvoreno, uključujući temeljnog pitanja razvojne neurobiologije: da li je isti regulatorni mehanizam potreban i za neuronalni razvoj u čovjeka? Na osnovi preliminarnih rezultata, naša je hipoteza da ljudski CELF1 regulira mRNA translaciju tijekom razvoja neuralnih progenitorskih stanica, te da je CELF1-regulacija ključna tijekom razvoja moždane kore čovjeka. Hipotezu ćemo testirati u sklopu sljedećih ciljeva: (1) Utvrditi funkcije CELF1 u razvoju humanih neuralnih progenitorskih stanica (NPC) i induciranih neurona (iN) dobivenih iz normalnih induciranih pluripotentnih stanica (iPSC); (2) Utvrditi mRNA-kandidate koji imaju ulogu u regulaciji CELF1 u humanim NPC i iN; (3) Utvrditi funkciju gena-kandidata u humanim NPC i iN. Na kraju predloženog istraživanja, utvrdit ćemo mRNA koje su translacijski regulirane u različitim stadijima neuronalnog razvoja čovjeka, njihovu funkciju, te gdje i kada su eksprimirane, te ćemo značajno unaprijediti naše razumijevanje uloge mRNA translacije u neuronalnom razvoju moždane kore čovjeka.]]></summary_hr><summary_en><![CDATA[Neurodevelopment relies on the precise orchestration of gene expression at specific developmental times in particular cell types. We have known for decades the importance of transcriptional regulation in cortical development. However, only recently mRNA translation has emerged as another important regulatory pathway that controls mouse cortical development. Dr. Rasin group has shown that mRNAs are transcribed but then await a signal to be translated into protein and mRNA translation in the developing mouse cortex is regulated by RNA binding proteins (RBPs). One of these RBPs, Celf1, is expressed in early progenitors and is needed for differentiation of glutamatergic neurons. Despite these impressive advances, research gaps remain including whether mRNA translation regulates human neurodevelopment – a fundamental question in neuroscience. To address this question, our team will combine the following resources: human cortical development (Krsnik), mRNA translation regulation (Rasin) and human neural precursor cells (Millonig). We will test the following hypothesis: human CELF1 regulates mRNA translation during human NPC and neuronal development and the downstream CELF1 regulated mRNAs will be important regulators of human neurodevelopment. To test this hypothesis the assembled international research team will perform the following three aims: (1) CELF1 will be knocked-down in human NPCs and induced neurons and the effect on development determined; (2) To identify the mRNAs regulated by CELF1, an unbiased RNA-seq screen will be performed and expression pattern determined; (3): The function of CELF1-regulated mRNAs will be tested in human NPC and induced neurons. At the completion of this study, we will determine the mRNAs that are translationally regulated during human neuronal development, their functions,  when and where they are expressed, significantly extending our understand of mRNA translation and its role in human neurodevelopment]]></summary_en></project><project>
<id>9280</id><title_hr><![CDATA[Unaprjeđenje planiranja i gospodarenja zelenom infrastrukturom kroz participativno mapiranje kulturnih usluga ekosustava]]></title_hr><title_en><![CDATA[]]></title_en><user_id>7421</user_id><user_firstLast_name>Silvija  Krajter Ostoić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-6490</code><acronim><![CDATA[CULTUR-ES]]></acronim><duration>01.09.2020 - 28.02.2023</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Šumarstvo, </scie_field_hr><scie_field_en>Forestry, </scie_field_en><institution_hr><![CDATA[Hrvatski šumarski institut]]></institution_hr><institution_en><![CDATA[Croatian Forest Research Institute]]></institution_en><team_members_id>25107</team_members_id><team_members_names><![CDATA[ Doktorand: Ana Marija Marin ]]></team_members_names><keywords_hr><![CDATA[zelena infrastruktura, percepcija građana, kulturne usluge ekosustava, participativno mapiranje, fokus grupe, upitnik, webGIS]]></keywords_hr><keywords_en><![CDATA[green infrastructure, citizen perception, cultural ecosystem services and disservices, participatory mapping, focus groups, survey, webGIS]]></keywords_en><summary_hr><![CDATA[Važnost zelene infrastrukture (ZI) za kvalitetu života u gradovima neprestano raste. Raste i broj ljudi koji žive u urbanim sredinama, pa ih je tako u Europi već sada tri četvrtine. ZI pruža brojne usluge ekosustava te ju je prepoznala i Europska komisija kao alat za prostorno planiranje koji je mnogostruko koristan za ispunjavanje ciljeva brojnih politika (prostornog planiranja, zaštite prirode i bioraznolikosti, prilagodbe na klimatske promjene i slično). Kulturne usluge ZI definiraju se prema Milenijskoj procjeni ekosustava kao „nematerijalne koristi ekosustava koje ljudima pružaju duhovno obogaćivanje, kognitivni razvoj, promišljanje, rekreacijske i estetske usluge“. Važnost istraživanja kulturnih usluga ekosustava ogleda se u činjenici da u Europi prevladavaju kulturni krajobrazi, a potražnja za njima u razvijenim zemljama sve više raste što će se nastaviti i u budućnosti. S druge strane u demokratskim društvima raste i potreba za većim uključivanjem javnosti u odlučivanje vezano za planiranje i gospodarenje ZI, dok izostanak javnosti često dovodi do otpora i protesta. Participativnim mapiranjem kulturnih usluga ZI prikupljaju se podatci o tome kako ljudi percipiraju ili koriste kulturne usluge ZI te je takva informacija korisna za daljnje prostorno planiranje i gospodarenje ZI. Cilj ovog projekta je na primjeru grada Zagreba identificirati, kvantificirati i mapirati kulturne usluge i štete na osnovu percepcije građana, otkriti što utječe na njihovu percepciju  te dati preporuke kako uključiti rezultate participativnog mapiranja u poboljšanje postojećeg sustava prostornog planiranja i gospodarenja ZI. U projektu će se koristiti kvalitativne i kvanititativne metode i alati (fokus grupe, upitnici, webGIS). Očekuje se da će projekt unaprijediti postojeća znanja o kulturnim uslugama i štetama od urbane ZI, naročito u smislu kvantificiranja neopipljivih koristi, ali i šteta, elemenata koji su često isključeni u dosadašnjim istraživanjima.]]></summary_hr><summary_en><![CDATA[With growing population in urban areas both globally and in Europe, importance of green infrastructure (GI) for quality of life is constantly increasing. GI provides various ecosystem services (ES) and is recognised by European Commission as a tool for achieving goals of various policies (spatial planning, nature and biodiversity conservation, climate change adaptation, etc.). According to the Millennium Ecosystem Assessment, cultural ES are defined as „the nonmaterial benefits people obtain from ecosystems through spiritual enrichment, cognitive development, reflection, recreation, and aesthetic experiences”. Importance of studying cultural ES is reflected in prevalence of cultural landscapes in Europe, demand for them is constantly increasing, and it will continue in future. On the other side, there is an increasing demand in democratic societies to include public in decision making with regard to planning and management of GI, while public exclusion from the process often leads to protests.  Participatory mapping of cultural ES collects data on how public perceive cultural ES from urban GI, which is useful input for future planning and management of urban GI. The goal of this project is to identify, quantify and map cultural ES and disservices from urban GI based on public perception, explore what affects the perception, and to give recommendation on how to include results of participatory mapping in current spatial planning and management of urban GI. Mix of qualitative and quantitative methods and tools will be used for that purpose (focus groups, survey, webGIS). The project will enhance knowledge on cultural ES and disservices from urban GI, especially in terms of quantification of non-material benefits, as well as disservices from GI since these are often excluded from research on cultural ES. ]]></summary_en></project><project>
<id>9281</id><title_hr><![CDATA[Antibakterijska prevlaka za biorazgradive medicinske materijale]]></title_hr><title_en><![CDATA[]]></title_en><user_id>158</user_id><user_firstLast_name>Iva Rezić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-9063</code><acronim><![CDATA[ABBAMEDICA]]></acronim><duration>15.02.2021 - 14.04.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Tekstilna tehnologija, </scie_field_hr><scie_field_en>Textile technology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Tekstilno-tehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Textile Technology]]></institution_en><team_members_id>864845</team_members_id><team_members_names><![CDATA[ Doktorand: Mislav Majdak ]]></team_members_names><keywords_hr><![CDATA[kemija materijala, nanočestice, sol-gel modifikacija, antimikrobna zaštita, tanke prevlake, optimiranje]]></keywords_hr><keywords_en><![CDATA[materials chemistry, nanoparticles, sol gel modification, antimicrobial protection, thin coating, optimisation]]></keywords_en><summary_hr><![CDATA[Do 2050. godine od infekcija koje uzrokuju bakterije otporne na antibiotike moglo bi umrijeti više ljudi nego od AIDSa, tuberkuloze i virusnog hepatitisa zajedno. Samo u Europi 25000 smrtnih ishoda godišnje i troškovi > 1.5 milijarde eura posljedica su rezistentnih mikroorganizama. U ovom će projektu stoga biti razvijeni novi biorazgradivi medicinski materijali s antimikrobno aktivnom prevlakom učinkovitom protiv infekcija sojevima Staphylococcus Aureus na koje ne djeluju antibiotici (MSSA, MRSA). Time će se odgovoriti na zahtjeve Svjetske zdravstvene organizacije koja je ovaj problem istaknula kao glavni problem globalnom javnom zdravlju. Istraživanja će obuhvatiti razvoj antimikrobne prevlake za: i) vodoodbojnu posteljinu, ii) jednokratne antimikrobne obloge te iii) antimikrobne biorazgradive katetere. U razvoju antimikrobne formulacije primijeniti ćemo “beyond-state-of-the-art“ QSAR metode predviđanja djelovanja smjesa nanočestica s drugim biološki aktivnim tvarima pomoću metode odzivnih površina unutar računalnog programa dizajna eksperimenta. Tako proračunate antimikrobne smjese upotrijebiti će se za funkcionalizaciju površine biorazgradivih polimera kombinacijom sol-gel postupka, mikrokapsuliranja, elektroispredanja i 3D-tiska. Nove medicinske polimere karakterizirati ćemo spektroskopskim (LA-ICP-MS/MS, HPLCMS/MS Q-TOF te GC-MS/MS Q-TOF, NTA, UVVIS, ICPOES, GFAAS), kromatografskim (GC, TLC) i mikroskopskim (SEMEDX, TEM) metodama. Nakon modifikacije polimera, ispitat će se njihova nova funkcionalna svojstva (vodoodbojnost, antimikrobnost, postojanost, zeta potencijal). Provedba projekta pomoći će osnaživanju međunarodne interdisciplinarne istraživačke grupe i povećati istraživački potencijal ustanove nabavom nove opreme. Planira se prijava patenta čime će biti podržan razvoj farmaceutske i tekstilne industrije. Transferom znanja među europskih sveučilišta (Zagreba, Oxforda, Beča) poduprijeti će se integracija hrvatskih znanstvenika u europski istraživački okvir]]></summary_hr><summary_en><![CDATA[By the year 2050, more people will dye from infections caused by antibiotic-resistant bacteria than from AIDS, tuberculosis and viral hepatitis together. Only in Europe 25,000 deaths per year and costs over 1.5 billion euro are linked to the resistant microorganisms. Therefore in this project, new biodegradable medical materials with antimicrobial active coating will be developed against Staphylococcus Aureus MSSA and MRSA strains. This will address the priority demands of the World Health Organization, which has highlighted this problem as a major problem for the global public health. The research will include the development of antimicrobial coatings foreseen as: i) bedding materials, ii) wound coatings, and iii) biodegradable catheters. In the development of antimicrobial formulations, we will apply the &#39;&#39;beyond-state-of-the-art&#39;&#39; QSAR methods for prediction of antimicrobial properties of nanoparticles with other biologically active substances by response surface methodod and Design of Experiment. Optimized mixtures will be used for functionalization of biodegradable polymers by a combination of sol-gel process, microcapsulation, electrospinning and 3D printing. New polymers will be characterized by spectroscopic (LA-ICP-MS/MS, HPLCMS/MS Q-TOF, GC-MS/MS Q-TOF, NTA, UV-VIS, ICP-OES, GF-AAS), chromatographic (GC, TLC) and microscopic (SEM-EDX, TEM) techniques. After the modification of polymers, their new functional properties will be examined (water-resistance, antimicrobial, stability, zeta potential). The implementation of the project will strengthen the international interdisciplinary research group and increase the research potential of the institution by purchasing new equipment. A patent application is planned to support the development of the pharmaceutical and textile industries. Moreover, knowledge transfer between European universities (Zagreb, Oxford and Vienna) will support the integration of Croatian scientists into the European research framework.]]></summary_en></project><project>
<id>9282</id><title_hr><![CDATA[Mikrobiom glavate želve (Caretta caretta): uvid u epizoičke i endozoičke zajednice]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4337</user_id><user_firstLast_name>Sunčica Bosak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-8248</code><acronim><![CDATA[TurtleBIOME]]></acronim><duration>26.10.2020 - 26.10.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>858354</team_members_id><team_members_names><![CDATA[ Doktorand: Lucija Kanjer ]]></team_members_names><keywords_hr><![CDATA[Mikrobiom, dijatomeje, morske kornjače, morska mikrobna ekologija, epizojske zajednice]]></keywords_hr><keywords_en><![CDATA[Microbiome, diatoms, sea turtles, marine microbial ecology, epizoic community  ]]></keywords_en><summary_hr><![CDATA[Mikrobiom predstavlja vitalni sustav koji se počeo razmatrati kroz paradigmu holobionta i opisivati kao cjelokupan sustav biljke/životinje zajedno s mikroorganizmima koji žive unutar ili na površini organizma. Morske kornjače su karizmatični morski kralješnjaci, među najugroženijim vrstama na svijetu. Nedavno je otkriveno da oklop morskih kornjača naseljavaju jedinstvene i brojne zajednice fotosintetskih mikroorganizama od kojih su najznačajnije dijatomeje. Jedinstvene vrste epibiontskih dijatomeja koloniziraju vanjske površine morskih kornjača, kožu i oklop, a novootkrivene epizoičke svojte pronađene su na svim vrstama morskih kornjača diljem svijeta. Unatoč važnosti i fundamentalnoj ulozi mikroorganizama u fiziološkim procesima morskih kornjača, u potpunosti nedostaju podaci o epibiontskim bakterijama,dok je sastav bakterijskih zajednica u probavilu samo sporadično opisan. Znanstveni doprinos predloženog projekta je pružiti jasnu sliku mikrobiološkog sastava površinskog biofilma i mikrobioma probavila glavatih želvi koje su najbrojnija vrsta morskih kornjača u Jadranu i Mediteranu. Kako bi ispunili zadani cilj koristiti ćemo najsuvremeniji molekularni pristup, ali i uhodane tradicionalne metode. Ovaj uspostavni istraživački projekt okuplja mlade i kompetentne znanstvenike u jedinstvenu sinergističku skupinu koja je sposobna postaviti temelj novom interdisciplinarnom istraživačkom pristupu u ekologiji i zaštiti mora te biologiji mora. Predloženi projekt će pružiti temeljne podatke o sastavu zajednica mikrobioma glavatih želvi koje će nadograditi postojeće znanje o ponašanju morskih kornjača, njihovim migracijskim putevima i staništima ishrane te pridonijeti dugotrajnim planovima zaštite morskih kornjača. Znanja prikupljena ovim projektom mogu se u budućnosti primijeniti za praćenje i zaštitu i drugih ugroženih morskih kralješnjaka poput dupina ili kitova, posebice jer će omogućiti nove spoznaje u svjetlu globalnih klimatskih promjena.]]></summary_hr><summary_en><![CDATA[The microbiome has become increasingly regarded as a vital system, currently viewed through paradigm of holobiont, describing the plant/animal together with the organisms living within or on their surface. Sea turtles are charismatic marine vertebrates and among the most endangered animals in the world. Recent findings show that sea turtles harbour unique and abundant epizoic microbial communities on their carapaces. Sea turtle-associated diatoms show ability to colonize the surface of animal tissues, both skin and carapace and new species/genera have been described worldwide from all sea turtle species. In spite of their importance and essential role in the host animal physiological functions there are huge knowledge gaps on the sea turtle holobiont. Our proposal aims to describe sea turtle microbial biodiversity by studying surface biofilm community and the gut microbiome of loggerhead turtles occurring in the Adriatic Sea. We will achieve this goal by pairing state-of-the-art culture-independent molecular approach with classic research methods. This installation research project aims to combine efforts of young and competent scientists in a single cohesive group that will set out the foundation for an interdisciplinary research approach in fields of marine ecology, marine biology and conservation. The proposed study will provide baseline data on the composition of loggerhead microbiome that might be integrated with the existing information on sea turtle behaviour, their migration routes, and foraging habitats thus contributing to a long term plans for sea turtle protection. Provided set of tools and methods may be applied in the future to other endangered marine animal-microbe associations in the rapidly changing world we live in.]]></summary_en></project><project>
<id>9283</id><title_hr><![CDATA[Povezanost genskih polimorfizama s temporomandibularnim poremećajima]]></title_hr><title_en><![CDATA[]]></title_en><user_id>612</user_id><user_firstLast_name>Iva Alajbeg</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-2322</code><acronim><![CDATA[GenPolTMD]]></acronim><duration>15.12.2020 - 14.06.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Dentalna medicina, </scie_field_hr><scie_field_en>Dental medicine, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Stomatološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Dentistry]]></institution_en><team_members_id>858422</team_members_id><team_members_names><![CDATA[ Doktorand: Marko Zlendić ]]></team_members_names><keywords_hr><![CDATA[temporomandibularni poremećaji, orofacijalna bol, polimorfizam jednog nukleotida, genetika boli, genetski čimbenici rizika, opiorfin]]></keywords_hr><keywords_en><![CDATA[temporomandibular disorders, orofacial pain, single nucleotide polymorphisms,  pain genetics, genetic risk factors, opiorphin]]></keywords_en><summary_hr><![CDATA[Temporomandibularni poremećaji (TMP) najčešći su orofacijalni bolni poremećaji nedentalnog porijekla, s prevalencijom u populaciji 6,1-10,2% i incidencijom od 3,9%. Patološki supstrat uglavnom izostaje, a uzrok često ostaje nepoznat. Kako se za druga bolna stanja nejasnog porijekla (npr. fibromialgija) predlažu genski čimbenici, cilj je našeg istraživanja ispitati predstavlja li genetska predispozicija rizik za nastanak TMP-a. Stoga ćemo određivati ciljne polimorfizme u odabranim genima u osoba s TMP-om (DK/TMP upitnik) i kontrolnih ispitanika te istražiti postoji li povezanost polimorfizama i odgovora na liječenje. Hipoteze: (I) pojavnost specifičnih genskih polimorfizama (usporedba pacijenata i kontrole) primarno ovisi o prisustvu/odsustvu TMP-a, a moguće i o izvoru i intenzitetu boli, prisustvu promjena na kosti, prisutnim psihološkim značajkama i prethodnoj ortodontskoj terapiji te (II) odgovor na liječenje razlikovat će se ovisno o prisutnim polimorfizmima. Usporedno s anamnestičkom i kliničkom obradom, te terapijom okluzijskom udlagom, provest će se analiza genomske DNA iz obriska bukalne sluznice. Izdvojena DNA koristit će se za određivanje 19 polimorfizama odabranih gena metodom Real-Time PCR. Paralelno, provest će se analiza biljega oksidacijskog stresa i opiorfina iz sline, čija je povezanost s TMP-om dokazana našim prethodnim istraživanjima. Ovaj put, njihova će se koncentracija usporediti s polimorfizmima u genima promotorima odgovornima za njihovu sintezu. Očekujemo da će se određene skupine polimorfizama pokazati kao faktor rizika za TMP-a. Inovativnost u smislu utvrđivanja genetske sklonosti za razvoj TMP-a ima potencijal za komercijalizaciju genetičkog testa kojim bi se mogao procijeniti rizik za razvoj bolesti i/ili odgovor na liječenje, čime bi se mogla indicirati rana intervencija i aktivno izbjegavanje okolišnih čimbenika rizika.]]></summary_hr><summary_en><![CDATA[Temporomandibular disorders (TMD) are the most common orofacial pain disorders of non-dental origin with the prevalence of 6.1–10.2%, and incidence of 3.9%. Observable pathology is mostly absent, and the etiology often remains unknown. Since some other painful conditions of unknown origin (eg. fibromyalgia), also imply genetic factors, the aim of the study is to investigate genetic predisposition in relation to the risk for TMD onset. This will be achieved through analysis of polymorphisms in the selected genes in TMD patients (DC/TMD) and matched control subjects. The possibility of involvement of specific polymorphisms in modulation of therapy response will also be investigated. The hypotheses: (I) the Single Nucleotide Polymorphism (SNPs) clustering will be dependent on presence or absence of TMD (comparison of patients with control subjects), and will possibly depend on source of pain, pain intensity, presence of bone changes, psychological features and previous orthodontic therapy, and (II) SNPs will influence the treatment response. Along with anamnestic and clinical examination and occlusal splint therapy, genomic DNA will be analyzed from the buccal swabs. Isolated DNA will be used for the determination of 19 polymorphisms of selected genes using Real-Time PCR method. The analysis of salivary oxidative stress markers and opiorphin will be also performed, as their relationship with TMD has been shown previously. This time, their concentration will be associated with polymorphisms in the promoters of genes responsible for their synthesis. We expect to show that particular gene profile or group of SNPs represent a risk factor for TMD development. Innovative approach of the concept of determining the genetic predisposition for TMD has the potential for development of commercial genetic test with potential for risk estimation in relation to TMD onset. This could enable early interventions and active avoidance of environmental risk factors.]]></summary_en></project><project>
<id>9285</id><title_hr><![CDATA[Modeliranje mreže prapovijesnih naselja u Slavoniji]]></title_hr><title_en><![CDATA[]]></title_en><user_id>25165</user_id><user_firstLast_name>Rajna Šošić Klindžić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-4231</code><acronim><![CDATA[MOPRENS]]></acronim><duration>01.10.2020 - 30.09.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Arheologija, </scie_field_hr><scie_field_en>Archeology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>856141</team_members_id><team_members_names><![CDATA[ Doktorand: Goran Tomac ]]></team_members_names><keywords_hr><![CDATA[Neolitik, Modeliranje bazirano na agentima, Mreža naselja, Društveni odnosi, Paleookoliš, Geoarheologija, Kronologija neolitika]]></keywords_hr><keywords_en><![CDATA[Neolithic, Agent-based modelling, Settlement Pattern, Social dynamics, Paleoenvironment, Geoarchaeology, Neolithic Chronology]]></keywords_en><summary_hr><![CDATA[Glavni cilj projekta je razumijevanje dinamike života u kasnom neolitiku Slavonije kroz računalne simulacije i izradu modela društvene dinamike. Za izgradnju modela koristit će se podaci prikupljeni terenskim i laboratorijskim istraživanjima u sklopu projekta, te rezultati prethodno provedenih istraživanja. Postojeći okvir arheoloških interpretacija oslanja se na teorijske modele i misaone koncepte posuđene iz drugih društvenih i humanističkih disciplina, a koji su formirani tijekom prve polovice 20. stoljeća te se kao takav pokazao nedostatnim za sveobuhvatno razumijevanje društvene dinamike u prošlosti. Paradigmatske promjene u arheologiji 21. stoljeća zahtijevaju nove teorije i objasnidbene modele za interpretaciju života u prošlosti. U sklopu projekta koristit će se modeliranje temeljno na agentima (ABM) jer daje rezultate koji odražavaju stohastičke procese, slično kao i povijest ljudskih aktivnosti te time nadilazi tradicionalna ograničenja analize i interpretacije prošlosti. Na ovom projektu bit će angažirani stručnjaci iz 4 znanstvena polja: arheologije, geologije, biologije i sociologije. Svaki od suradnika na projektu specijaliziran je za određenu istraživačku problematiku i analizu specifične vrste podataka: analizu materijalne kulture, analizu prostornih podataka, podatkovnu znanost, izgradnju  simulacijskih modela, proučavanje društvene dinamike, terenska istraživanja i zračna rekognosciranja, geološke i geoarheološke analize te analize faunskih i biljnih ostataka. Veliki i heterogeni skupovi podataka prikupljeni tijekom projekta će se analizirati i modelirati računalnim metodama kroz nove načine konceptualizacije, razine razmjera i detaljnosti u istraživanju društvenih promjena. Kroz primjenu ABM istraživat će se međusobni odnosi različitih varijabli u prostornom okruženju naseljenom agentima koji oponašaju društvene skupine u svrhu modeliranja mogućih uzroka i odrednica društvene dinamike i društvene promjene u neolitiku Slavonije.]]></summary_hr><summary_en><![CDATA[The main goal of the project is to understand the social dynamic in the late Neolithic Slavonia through computational simulations and the development of social and cultural relations and change models which will be built using data collected by field and laboratory research within the project, as well as the results of the previously conducted research.The existing framework of archaeological interpretations relies on theoretical models and concepts developed by other social and humanistic disciplines, formed during the first half of the 20th century and as such proved inadequate for a comprehensive understanding of social dynamics in the past. Paradigmatic changes in the 21st century archeology require new theories and explanatory models for the interpretation of life in the past.As part of the project, agent-based modelling (ABM) will be used, because it produces results that reflect stochastic complexity, similar to the history of human activities, thus exceeding the traditional limitations of interpretation and analysis of the past.This project will involve experts from 4 scientific fields: archaeology, geology, biology and sociology. Each of the team members is an expert in specific research issues and analysis of specific data sets: analysis of material culture, spatial data analysis, data science, agent-based modelling, social dynamics, field research and remote sensing, geological and geo-archaeological analysis, and analysis of fauna and plant residues. Large and heterogeneous data sets collected during the project will be analysed and modeled by computational methods through new ways of conceptualization, scale and resolution in social complexity and change research. Through the application of ABM, mutual relations of different variables in a spatial environment populated by agents that mimic social behavior will be investigated in order to build models of possible causes and reasons of social dynamics and social change in the Neolithic Slavonia.]]></summary_en></project><project>
<id>9286</id><title_hr><![CDATA[Integrating high resolution solar physics (SOLARNET)]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4850</user_id><user_firstLast_name>Bojan Vršnak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-8750</code><acronim><![CDATA[]]></acronim><duration>01.09.2020 - 30.11.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Geodetski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Geodesy]]></institution_en><team_members_id>855869</team_members_id><team_members_names><![CDATA[ Doktorand: Karmen Martinić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>9287</id><title_hr><![CDATA[Koncept nepomičnog pola u numeričkom modeliranju Cosseratovog kontinuuma]]></title_hr><title_en><![CDATA[]]></title_en><user_id>527</user_id><user_firstLast_name>Gordan Jelenić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-5283</code><acronim><![CDATA[FIMCOS]]></acronim><duration>02.03.2021 - 23.11.2026</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Temeljne tehničke znanosti, </scie_field_hr><scie_field_en>Basic engineering sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Građevinski fakultet u Rijeci]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Civil Engineering]]></institution_en><team_members_id>864842</team_members_id><team_members_names><![CDATA[ Doktorand: Magdy Ismail ]]></team_members_names><keywords_hr><![CDATA[Cosseratov kontinuum, opis metodom nepomičnoga pola, metoda konačnih elemenata, objektivnost, konzervativna integracija, identifikacija parametara]]></keywords_hr><keywords_en><![CDATA[Cosserats&#39; continuum, fixed-pole description, finite-element method, objectivity, conservative integration, parameter identification]]></keywords_en><summary_hr><![CDATA[U ovome projektnom prijedlogu razmatra se alternativna teorija kontinuuma poznata pod nazivom Cosseratova ili mikropolarna teorija. Predlaže se provedba detaljnije analize u okviru  takozvane metode nepomičnog pola s ciljem razvoja točnih i djelotvornih konačnih elemenata za linearnu i nelinearnu statičku i dinamičku analizu.Elementi će biti razvijeni slijedom niza istraživačkih ciljeva koji se sastoje od (O1) linearne statičke analize, (O2) nelinearne statičke analize, (O3) dinamičke analize i (O4) identifikacije parametara. Na taj način, putem ciljeva O1-O3 razvijeni elementi će tvoriti simulacijski alat sami za sebe, dok će putem cilja O4 stvoriti neophodni preduvjet za robusnu i pouzdanu proceduru potrebnu za identifikaciju materijalnih parametara iz eksperimentalnih mjerenja. Konačni elementi će biti provjereni putem niza standardnih testnih primjera, a par eksperimentalnih postava bit će projektiran da zaključi cilj O4. Ciljevi će biti dosegnuti kroz niz istraživačkih, edukacijskih i upravljačkih aktivnosti koje će voditi članovi projektne grupe i koji će se bazirati na ranijim dostignućima grupe u razvoju konačnih elemenata uključujući vezanu interpolaciju, objektivnu interpolaciju ovisnu o konfiguraciji, algoritme za vremensku integraciju, Cosseratovu elastičnost, metodu nepomičnog pola u nelinearnim gredama i iskustvo u provedbi beskontanog mjerenja. Konačni elementi će biti razvijeni unutar programa za analizu metodom konačnih elemenata FEAP.S projektnim rezultatima upoznat ćemo eksperte i širu javnost putem raznih diseminacijskih kanala, uključujući objave u znanstvenim časopisima najviše kategorije u području računske mehanike, predstavljanja na uglednim specijaliziranim konferencijama, kao i predavanja s ciljem populariziranja projektnoga istraživanja i znanosti općenito.]]></summary_hr><summary_en><![CDATA[An alternative continuum theory called Cosserats’ or micropolar theory is considered within this proposal and a case is made for its more thorough analysis within the framework of the so-called fixed-pole description with the aim of providing accurate and efficient finite elements for linear and non-linear static and dynamic analysis. The elements will be developed by pursuing a set of research objectives consisting of (O1) linear static analysis, (O2) non-linear static analysis, (O3) dynamic analysis and (O4) parameter identification. In this way, through objectives O1-O3 the elements developed will be usable as a simulation tool in their own right while in O4 they will make a vital pre-requisite for a robust and reliable procedure needed for identification of material parameters from experimental measurements. The finite elements will be tested against a number of bench-mark problems, while a couple of experimental setups will be designed to complete O4.The objectives will be reached through a series of research, training and management activities led by the members of the project team and built on previous achievements of the team in finite-element design involving linked interpolation, objective configuration-dependent interpolation, time-stepping algorithms, conventional Cosserats&#39; elasticity, fixed-pole approach in geometrically exact beams as well as experience in performing contactless measurements. The finite elements will be developed within the finite-element-analysis programme FEAP.The project results will be communicated to the professionals and general public through a variety of dissemination channels involving publications in the scientific journals of the highest rank within the area of computational mechanics, presentations at highly reputable thematic conferences, and lectures aimed at popularising the project research and science in general.]]></summary_en></project><project>
<id>9289</id><title_hr><![CDATA[ŽIVOT NA RIMSKOJ CESTI: komunikacije, trgovina i identiteti na rimskim cestama u Hrvatskoj od 1-8-.st.]]></title_hr><title_en><![CDATA[]]></title_en><user_id>2786</user_id><user_firstLast_name>Ivana Ožanić Roguljić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-5348</code><acronim><![CDATA[LRR]]></acronim><duration>01.09.2020 - 29.04.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Arheologija, </scie_field_hr><scie_field_en>Archeology, </scie_field_en><institution_hr><![CDATA[Institut za arheologiju]]></institution_hr><institution_en><![CDATA[Institute of Archaeology in Zagreb]]></institution_en><team_members_id>855859</team_members_id><team_members_names><![CDATA[ Doktorand: Jere Drpić ]]></team_members_names><keywords_hr><![CDATA[rimska cesta, rimska keramika, rimska provincija Panonija,  rimska provincija Dalmacija, Avari]]></keywords_hr><keywords_en><![CDATA[Roman road, Roman ceramics, Roman province of Pannonia, Roman province of Dalmatia, Avari]]></keywords_en><summary_hr><![CDATA[Ceste u rimsko doba bili su arterije samog Carstva. Povezivali su provincije i gradove, a bez njih Rimljani nisu mogli niti osvojiti niti zadržati se na područjima kojima su vladali. Oni su bili sredstvo za pomicanje vojnih dužnosnika, civila i prijevoz robe. Rimske ceste stvorile su poveznice po kojima je u razdobljima nakon propasti Carstva organiziran život i osnivanje različitih naselja. Inženjerske i geodetske vještine Rimljana pružile su temelj mnogim današnjim rutama. Život na nekim rimskim cestama nastavio se i nakon pada Carstva i nije prestao do danas. Glavni cilj projekta je interpretacija svakodnevnog života na rimskoj cesti, od početka rimske vlasti do razdoblja propasti, akulturacije i integracije novih identiteta. Ovaj projekt nudi priliku za novu perspektivu: kako se život razvija oko rimskih cesta i staze tijekom glavne upotrebe cesta i nakon što je završio? Fokus projekta biti će razdijeljen na dva gledišta: 1. Život na rimskim cestama i stazama u rimsko doba, s obzirom na regionalne razlike (Lika - cesta Žuta Lokva, istočna Slavonija - Cibalae - Mursa), 2. Život neposrednih nasljednika (otok Korčula - cesta oko rimskih, kasnoantičkih i bizantske Lumbarde) i neizravnih sljedbenika (populacija kasnog Avarskog stanovništva iz 3 mjesta oko Cibala u istočnoj Slavoniji, bivša rimska pokrajina Panonnia Sirmiensis), rimska kulture u post-rimskom svijetu. U LRR projektu rimske ceste će se proučavati kao osnovna arterija rimskog svijeta, ali i kao metafora uvođenja, prihvaćanja i života rimskog načina života. Nakon propasti rimskog svijeta rimske ceste predstavljaju metaforu baštine i tradicije onoga što je nekada bilo veliko carstvo.]]></summary_hr><summary_en><![CDATA[Roads in Roman time were the arteries of the Empire itself. They connected provinces and cities, and without them the Romans could not have conquered and held onto the territories they ruled. They were means of moving military officials, civilians and to transport goods. Roman roads gave excellent links for organizing life and establishing various settlements in periods after the collapse of the Empire. Engineering and surveying skills of the Romans provided the basis for many of today&#39;s routes. Life on some Roman roads continued after the fall of the Empire and has not stopped until today. The main objective of the project is an interpretation of everyday life on the Roman road, from the beginning of the Roman rule to the period of decline, acculturation and integration of new identities. This project offers a chance for a new perspective: how does the life develop around Roman roads and a path during the main usage of the roads and after it’s over? Focus of the project will have different viewpoints: 1.Life on the Roman roads and paths in Roman times, considering the regional differences (Lika region – Road station Žuta Lokva;  Eastern Slavonia – Cibalae – Mursa route) 2.Life of direct successors (island Korčula – road around Roman, late Roman and Byzantine Lumbarda) and indirect followers (Late Avar population from 3 sites around Cibalae in Eastern Slavonia, former Roman province Panonnia Sirmiensis) of Roman culture in post-Roman world. In LRR project Roman roads will be studied as basic artery of Roman world but also a as a metaphors of introducing, accepting and living the Roman way of life. After the decline of Roman world Roman roads represent the metaphors of heritage and tradition of what was once a huge Empire.]]></summary_en></project><project>
<id>9290</id><title_hr><![CDATA[IP-2019-04-8008: Fotokemija: Reakcijski mehanizmi i primjene u organskoj sintezi i biologiji (PhotoApp)]]></title_hr><title_en><![CDATA[]]></title_en><user_id>376</user_id><user_firstLast_name>Nikola Basaric</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-6706</code><acronim><![CDATA[]]></acronim><duration>01.10.2020 - 30.09.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>856185</team_members_id><team_members_names><![CDATA[ Doktorand: Josip Draženović ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>9291</id><title_hr><![CDATA[Multicentrične kovalentne veze i pi-interakcije određuju fizička svojstva kristala organskih radikala]]></title_hr><title_en><![CDATA[]]></title_en><user_id>13343</user_id><user_firstLast_name>Krešimir Molčanov</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-7132</code><acronim><![CDATA[MULTICENTRICBONDING]]></acronim><duration>21.01.2021 - 17.09.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>864856</team_members_id><team_members_names><![CDATA[ Doktorand: Petra Stanić ]]></team_members_names><keywords_hr><![CDATA[multicentrične kovalentne veze, međumolekulske interakcije, kristalografija, gustoća naboja, radikali]]></keywords_hr><keywords_en><![CDATA[multicentric covalent bonding, intermolecular interactions, crystallography, charge density, radicals]]></keywords_en><summary_hr><![CDATA[Glavni cilj projekta je dizajn i priprava kristala na bazi organskih radikala kod kojih se mogu ugađati prijenos naboja i energijski procijep, te njihov razvoj kao funkcionalnih materijala. Posebna pažnja bit će posvećena prirodi pi-interakcijâ između radikala, koje mogu imati djelomičan kovalentni karakter (multicentrične dvoelektronske veze, poznate kao &#39;palačinka-veze&#39;). Prirodu multicentričnih veza istraživat ćemo određivanjem eksperimentalne gustoće naboja iz rendgenske difrakcije te kombinacijom temperaturno ovisne rendgenske difrakcije i rendgenske difrakcije pri visokom tlaku. Istraživanja će se razvijati u dva glavna smjera: 1) priprava novih soli i sustava s prijenosom naboja temeljenih na organskim radikalima (uglavnom semikinonima, ali ćemo koristiti i druge planarne organske radikala) te određivanje njihovih svojstava (kristalna struktura, magnetska i električna svojstva) i 2) detaljno proučavanje multicentričnih kovalentnih veza i sličnih interakcija među organskim radikalima, na izabranim modelnim sustavima (kombinacijom određivanja gustoće naboja iz rendgenske difrakcije, temperaturno-ovisne difrakcije i difrakcije pri visokom tlaku te kvantno-kemijskih računa). Dodatni cilj ovoga projekta je uspostavljanje istraživanja gustoće naboja u Hrvatskoj; također ćemo započeti i s rendgenskom difrakcijom pri visokom tlaku.]]></summary_hr><summary_en><![CDATA[The main goal of the project is to design and prepare crystals of organic radicals suitable for tuning of the charge transfer and band gap, which can be used to design functional materials. Special attention will be given to the nature of pi-interactions between the radicals, which may involve partially covalent multicentric bonding (&#39;pancake bonding&#39;). We will undertake a thorough experimental study of the &#39;pancake bonds&#39; by X-ray charge density coupled by quantum chemical computations; under non-ambient conditions we will use high-pressure and variable-temperature single-crystal X-ray diffraction. Our work will branch into two main directions: 1) synthesis of novel salts and charge transfer compounds of organic radicals (mainly semiquinone radical anions, but similar planar organic radicals will also be used) and study of their properties (crystal structure, magnetic and electrical properties) and 2) in-depth study of multicentric covalent bonding and other interactions between stacked radicals on selected model compounds (a combination of X-ray charge density, non-ambient crystallography and quantum chemical computation). In addition, this project will be aimed towards establishing X-ray charge density research in Croatia, and will also introduce high-pressure X-ray diffraction.]]></summary_en></project><project>
<id>9297</id><title_hr><![CDATA[Mehanokemijska aktivacija i funkcionalizacija veze C–H potaknuta paladijem i usmjerena ligandom]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1007</user_id><user_firstLast_name>Marina Juribašić Kulcsar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-7515</code><acronim><![CDATA[]]></acronim><duration>10.12.2020 - 09.07.2025</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>862798</team_members_id><team_members_names><![CDATA[ Doktorand: Mario Pajić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>9298</id><title_hr><![CDATA[Primjena naprednih tehnologija obrade voda za uklanjanje mikroplastike]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4661</user_id><user_firstLast_name>Šime Ukić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-4379</code><acronim><![CDATA[AdWaTMiR]]></acronim><duration>15.09.2020 - 28.02.2026</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet kemijskog inženjerstva i tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Chemical Engineering and Technology]]></institution_en><team_members_id>856187</team_members_id><team_members_names><![CDATA[ Doktorand: Kristina Bule ]]></team_members_names><keywords_hr><![CDATA[onečišćene vode, mikroplastika, uklanjanje, napredne tehnologije obrade, inovativni reaktor]]></keywords_hr><keywords_en><![CDATA[contaminated water, microplastics, removal, advanced treatment technologies, inovative reactor]]></keywords_en><summary_hr><![CDATA[U današnje vrijeme ljudi postaju svjesni problema prisutnosti mikroplastike (MP) u okolišu. Zbog veličine čestica (< 5 mm), organizmi ju znatno lakše unose u sebe. Na taj se način povećava njihova izloženost plastici, što može imati neželjene zdravstvene posljedice. Dosadašnje studije uklanjanja MP-a iz voda su relativno rijetke i oskudne pa je glavni cilj AdWaTMiR-a upravo razvoj novih inovativnih metodologija obrade MP-a u vodama te izrada i potvrđivanje rezultata u novoizrađenom prototipu reaktora za uklanjanje. Razvijeni procesi odlikovati će se tehnološkom učinkovitoću, ekološkom prihvatljivošćui i ekonomskom opravdanošću, bit će održivi i kompatibilni principima kružne ekonomije.Istraživanja vezana za AdWaTMiR odvijat će se kroz 6 cjelina:1.	Priprema MP standarda 2.	Razvoj analitičkih metoda za određivanje MP-a u vodi3.	Biorazgradnja MP-a u vodenim suspenzijama4.	Degradacija MP-a u vodenim suspenzijama pomoću AOP-a5.	Uklanjanje MP-a iz vodenih suspenzija membranskim postupcima 6.	Spajanje MBR sustava s AOP-ovima u inovativnom reaktorskom sustavuHipoteze projekta su:1.	Napredni procesi biorazgradnje su učinkovit pristup uklanjanju MP-a iz vode.2.	AOP je učinkovit pristup uklanjanju MP-a iz vode.3.	AOP-MBR spajanje je učinkovitije od ostalih dvaju MP tretmana.AdWaTMiR je fokusiran na postizanje kratkoročnih politika Europske komisije u dijelu razvoja novih tehnologija i zaštite okoliša, koje moraju biti održive, energetski učinkovite, usklađene s paradigmom kružne ekonomije, te dugoročnih politika vezanih uz klimatske promjene. Osim šireg društvenog konteksta, ekonomski će se očitovati u mogućoj brzoj implementaciji novorazvijenih inovativnih tehnologija visoke dodane vrijednosti, unutar industrije i javnih tvrtki s izrazito brzim povratima investicija i blagotvornim financijskim efektima. Znanja dobivena ovim projektom biti će podloga za daljnja znanstvena i stručna istraživanja te uspostavu novih istraživačkih grupa kako unutar RH tako i na prostoru EU.]]></summary_hr><summary_en><![CDATA[Presence of small plastic particles (< 5 mm) in environment has gain increasing attention in recent years. These microplastics (MP) can be ingested more readily. The ingestion increases chemical exposure and, thus, might cause unwanted health problems.Studies dealing with MP removal from water are so far relatively rare and scarce. Therefore, the main goals of AdWaTMiR are development of innovative methodologies for MP removal from water suspensions and design of newly constructed reactor prototype for related MP removal. Developed processes will be distinguished by technological efficiency, environmental acceptability and economic feasibility, and will be sustainable and compatible with principles of the circular economy.AdWaTMiR research will have six phases:1.	Preparation of MP standards2.	Development of methods for MP determination in water3.	MP biodegradation in suspensions4.	MP degradation in suspensions by AOPs 5.	MP removal from suspensions by membrane processes 6.	Coupling of MBR system with AOPs in innovative reactor Project hypotheses are:1.	Advanced microbiological processes are an effective approach in removal of MP from water.2.	AOP is an effective approach in removal of MP from water.3.	AOP-MBR coupling is more effective than other two MP treatments by means of selected optimization criteria.AdWaTMiR is focused on achieving short-term policies of the EU Commission in area of new technologies development and environmental protection (which must be sustainable and energetically efficient) and long-term policies related to climate changes. In addition to broader social context, possible rapid implementation of newly developed high value-added technologies will be economically evident within industries and public companies with fast investment-returns and beneficial financial effects. Knowledge gained by the project will be basis for further scientific and professional researches and for establishment of new research groups, within Croatia and abroad.]]></summary_en></project><project>
<id>9306</id><title_hr><![CDATA[Dopaminska regulacija kompetitivnog ponašanja u kohabituirajućim populacijama guštera Podarcis siculus i Podarcis melisellensis]]></title_hr><title_en><![CDATA[]]></title_en><user_id>12445</user_id><user_firstLast_name>Sofia Ana Blažević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-4938</code><acronim><![CDATA[BOLDer]]></acronim><duration>09.11.2020 - 08.05.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>858391</team_members_id><team_members_names><![CDATA[ Doktorand: Dunja Šikić ]]></team_members_names><keywords_hr><![CDATA[ponašanje životinja, agresivno ponašanje, neuroetologija, neurotransmiteri, dopamin, HPLC, ekspresija gena, Podarcis, Lacertidae, competitive species]]></keywords_hr><keywords_en><![CDATA[animal behavior, aggresive behavior, neuroethology, neurotransmitters, dopamine, HPLC, gene expression, Podarcis, Lacertidae, competitive species]]></keywords_en><summary_hr><![CDATA[Agresivna i socijalna ponašanja utječu na dinamiku populacije, reprodukciju i raspodjelu energije unutar populacije. Ove paradigme ponašanja su rezultat monoaminskih neurotransmitera u mozgu – serotonin, dopamin (DA) i noradrenalin. Ovi neurotransmiteri su slabo proučeni u divljih životinja, u kojima uzročno-posljedične veze često nisu primjetne zbog fizioloških i bihevioralnih oscilacija unutar divljih populacija. Gušteri, amniotski kralježnjaci, usprkos tome što imaju jednostavniji mozak od sisavaca, s njima dijele u moždanom deblu zajednički neuronske krugove koji su odgovorni za motivacijsko ponašanje, uključujući agresiju. Ovaj jednostavniji mozak pogodan je za proučavanje temeljnih mehanizama kontrole ponašanja, s rezultatima koji se mogu translatirati na druge vrste. Poznato je da u istočnom Jadranu, Podarcis siculus, globalna invazivna vrsta, kompetitivno isključuje autohtonu Podarcis melisellensis. Nedavno smo pokazali u P. siculus dvostruko više dopamina nego u P. melisellensis. Projekt BOLDer ima za cilj proučiti ovaj jedinstveni model kohabituirajućih vrsta guštera kako bi razjasnili odnos između razlika u razinama neurotransmitera u mozgu i ekološku isključenost ovih vrsta. Konkretno, planiramo: 1) potvrditi razlike među vrstama u razinama DA u mozgu ove dvije vrste u različitm simpatrijskim populacijama (HPLC); 2) povezati ove razlike sa specifičnim komponentama agresivnog ponašanja (in situ i laboratorijska ispitivanja ponašanja); 3) ispitati stukturalne (histološko/imunohistokemijske) i transkripcijske (NGS transkriptoma i qRT-PCR) mehanizme koji određuju te razlike. BOLDER će formalno osnovati prvu neuroetološku istraživačku skupinu na Prirodoslovno-matematičkom fakultetu, koja će, svojim komparativnim pristupom, pokušati razjasniti osovinu koja povezuje agresivno ponašanje s regulacijom razine/aktivnosti neurotransmitera.]]></summary_hr><summary_en><![CDATA[Behaviors of aggressive and social character shape population dynamics, reproductive output, and energy balance within populations. These behavioral paradigms are the result of the activity of brain monoamine neurotransmitters – serotonin, dopamine (DA), and noradrenaline. These neurotransmitters are vastly understudied in wild animals and often, their causative roles in behavior are not directly evident due to behavioral and physiological variability within populations. Lizards, amniotic vertebrates, have simpler brains than mammals yet share with them common neural circuits in the brainstem that are responsible for motivational behavior including aggression. This simpler brain is favorable for studying underlying mechanisms of behavioral control, and the results could be translated to other species. It is well known that in the Eastern Adriatic, Podarcis siculus, a global invasive species, competitively excludes the native Podarcis melisellensis. We have recently demonstrated that P. siculus has twice as much dopamine in brain than P. melisellensis. The project BOLDer aims to study this unique model of coexisting lizards’ species to understand the relationship between differences in brain neurotransmitter content and ecological exclusion of these species. Specifically, we plan to:  1) demonstrate the interspecific differences in brain DA  levels between these two species across different sympatric populations (HPLC); 2) link these differences with specific components of aggressive behavior (in situ and lab. behavioral testing); and 3) examine structural (histology/immunohistochemistry) and transcriptional (transcriptome NGS and qRT-PCR) mechanisms that determine these differences. BOLDer will formally establish the first neuroethological research group at the Faculty of Science, that will, with its comparative approach, try to clarify the axis that links aggressive behavior with the regulation of neurotransmitter levels/activity.]]></summary_en></project><project>
<id>9308</id><title_hr><![CDATA[Reguliranje funkcije štitne i doštitne žlijezde i homeostaze kalcija u krvi]]></title_hr><title_en><![CDATA[]]></title_en><user_id>118</user_id><user_firstLast_name>Tatijana Zemunik</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-1220</code><acronim><![CDATA[THPTHCAREGULATION]]></acronim><duration>12.10.2020 - 12.04.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Split School of Medicine]]></institution_en><team_members_id>858324</team_members_id><team_members_names><![CDATA[ Doktorand: Nikolina Pleić ]]></team_members_names><keywords_hr><![CDATA[hormoni i antitijela štitne žlijezde, parametri homeostaze kalcija u krvi, genetska varijanca, predikcijska analiza, analiza ekspresije gena]]></keywords_hr><keywords_en><![CDATA[thyroid hormones and antibodies, parameters of calcium homeostasis, genetic variance, prediction analysis, gene expression analysis]]></keywords_en><summary_hr><![CDATA[Publicirani rezultati naše istraživačke skupine predstavljaju prve identificirane genetske varijante za većinu hormona/antitijela štitne žlijezde. Udio objašnjene genetske varijance za hormon doštitne žlijezde (PTH) iznosi samo 5,34% dok za kalcitonin i osteokalcin koji zajedno s PTH reguliraju homeostazu kalcija u krvi nema provedenih cjelogenomskih studija do sada. Predikcijske analize poprimaju sve veći značaj u posljednjih nekoliko godina. Cilj takvih analiza je predviđanje vrijednosti kvantitativnog svojstva baziranog na zajedničkom učinku genetskih i okolišnih čimbenika. Ovakav tip analiza nije primijenjen za predviđanje razine hormona/antitijela štitne žlijezde, kao ni za parametre koju reguliraju homeostazu kalcija u krvi. Stoga su prva dva cilja predloženog projekta povećanje udjela objašnjene genetske varijance za hormone/antitijela štitne žlijezde i parametara regulacije homeostaze kalcija u krvi i predikcija istih bazirana na genetskim i okolišnim čimbenicima. Istraživanje će biti provedeno na 2.000 ispitanika (populacije imenovane Korčula2, Korčula3), a rezultati će biti objedinjeni meta-analizom s prethodno dobivenim rezultatima na 3.000 ispitanika (populacije imenovane Split, Korčula1, Vis) za hormone i antitijela štitne i doštitne žlijezde, dok će analize za vrijednosti kalcitonina i osteokalcina biti provedene po prvi put na ukupno 5.000 ispitanika (u svim populacijama). Svi ispitanici regrutirani su iz projekta „10.001 Dalmatinac“ te raspolažemo genotipskim i nizom anamnestičkih i fenotipski mjerljivih podataka potrebnih za ove analize. Treći cilj projekta predstavlja funkcionalnu potvrdu identificiranih gena koji se povezuju s razinom tireoglobulina (Tg) i pozitivnim nalazom protutijela štitne žlijezde (TPOAt i/ili TgAt) u plazmi. Utvrdit će se razlika u ekspresiji dva gena u patološkom u odnosu na zdravo tkivo štitne žlijezde imunohistokemijskim metodama. Ovakva istraživanja preduvjet su razvoja personalizirane medicine.]]></summary_hr><summary_en><![CDATA[First identified genetic variants for most thyroid hormones/antibodies have been recently published by our research group. For now, only 5.34% of genetic variance has been explained for parathyroid hormone (PTH) levels while calcitonin and osteocalcin, which together with PTH regulate blood calcium homeostasis, have not been analysed on a genome-wide level. Prediction analyses have gained increasing significance over the last few years. The aim of such analyses is to predict the value of a quantitative trait based on genetic and environmental parameters. These analyses have not been performed in the prediction of thyroid hormones/antibodies levels or blood calcium homeostasis parameters. Therefore, the first two goals of the proposed project are increasing the amount of explained genetic variance of thyroid complex phenotypes and parameters of calcium homeostasis, and their prediction based on identified genetic variants and environmental factors. The analysis of thyroid hormones/antibodies will be performed in 2.000 participants (populations named Korčula2, Korcula3), and the results will be meta-analyzed with previously obtained results of 3.000 participants (populations named Split, Korcula1, Vis). Analyses of calcitonin and osteocalcin will be performed in a total of 5.000 participants (in all populations), for the first time. All participants are recruited through the project „10.001 Dalmatians“ and have genotypic and a series of anamnestic and phenotypic data needed for these analyses. The third project goal is based on the best results of our previous project and represents the functional studies of genes identified to be associated with thyroglobulin (Tg) plasma levels and positive antibody (TPOAb and/or TgAb) findings. It is planned to establish the difference in the gene expression between pathological and healthy thyroid tissue using immunohistochemical methods. Such studies are a prerequisite for the development of personalized medicine.]]></summary_en></project><project>
<id>9309</id><title_hr><![CDATA[Identifikacija cirkulirajućih biomarkera neurološkog oporavka u bolesnika s ozljedom mozga]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6187</user_id><user_firstLast_name>Kristina Grabušić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-4311</code><acronim><![CDATA[CiMozak / CirBrain]]></acronim><duration>10.09.2020 - 15.01.2026</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Medicine]]></institution_en><team_members_id>855982</team_members_id><team_members_names><![CDATA[ Doktorand: Vedrana Krušić ]]></team_members_names><keywords_hr><![CDATA[ozljeda mozga, neurološki oporavak, biomarkeri, cerebrospinalna tekućina, izvanstanične vezikule]]></keywords_hr><keywords_en><![CDATA[brain injury,  neurorecovery, biomarkers, cerebrospinal fluid, extracellular vesicles]]></keywords_en><summary_hr><![CDATA[Projektni prijedlog CiMozak usmjeren je na identifikaciju biomarkera neurološkog oporavka u bolesnika s teškom traumatskom ozljedom mozga. Ozljeda nastaje djelovanjem fizičke sile na glavu i dovodi do kome s potencijalnim smrtonosnim ishodom. Unatoč težini ozljede, moguć je potpuni neurološki oporavak. Međutim, nije poznato kada započinje oporavak mozga i koliko na njega utječu terapijske intervencije, jer nedostaje znanje o biomarkerima neurološkog oporavka.Glavni cilj je omogućiti praćenje oporavka mozga pomoću biomarkera u tjelesnim tekućinama. CiMozak ima snažno uporište u najnovijim ispitivanjima na životinjama koja pokazuju da odrasli mozak mijenja razine neuroregeneracijskih signala u cerebrospinalnoj tekućini (CSF). Nadalje, naši objavljeni i preliminarni rezultati analiza ljudskog CSF-a nakon ozljede mozga opisuju ranu indukciju: i) izvanstaničnih vezikula (IV-a), membranom obavijenih čestica koje se izlučuju iz stanica i prenose proteine i nukleinske kiseline; ii) novih proteina povezanih s neuroregeneracijom. Na temelju opisanih rezultata, CiMozak ima za cilj odrediti precizniju kinetiku promjena sljedećih elemenata u CSF-u: 1) veličine i broja IV-a pomoću nanotehnologije TRPS; 2) morfologije i proteinskog sadržaja IV-a pomoću elektronske mikroskopije; 3) subpopulacija IV-a pomoću kromatografije; 4) razina proteina povezanih s neuroregeneracijom pomoću spektrometrije; 5) sadržaj mikroRNA pomoću lančane reakcije polimerazom RT-PCR. Biomarkeri koji će u 1. fazi CiMozak-a pokazati najviše razine u CSF-u, bit će analizirani u plazmi u sklopu 2. faze CiMozak-a.Očekuje se da će CiMozak donijeti nove spoznaje o identitetu i kinetici cirkulirajućih biomarkera neurološkog oporavka. Biomarkeri iz CSF-a i krvi mogli bi omogućiti neinvazivno praćenje neurološkog oporavka bolesnika ne samo nakon teške traumatske ozljede mozga već i drugih ozljeda i bolesti mozga. Time bi se također omogućilo određivanje utjecaja različitih terapijskih intervencija na oporavak mozga.]]></summary_hr><summary_en><![CDATA[The CirBrain proposal intends to identify biomarkers of neurorecovery in patients with severe traumatic brain injury (TBI). Severe TBI is an intracranial damage caused by the impact on the head leading to coma and possible fatal outcome. Despite the severity of injury, a complete neural recovery is possible. However, it is not known when brain recovery is initiated and how it might be affected by therapeutic interventions since knowledge about neurorecovery biomarkers is lacking.The major goal of CirBrain is to enable monitoring of brain recovery by biomarkers in body fluids. CirBrain is strongly supported by the latest studies in animals showing that the adult mammalian brain modifies levels of neuroregenerative signals in cerebrospinal fluid (CSF). Moreover, our published and preliminary post-TBI analyses of human CSF describe early induction of: i) extracellular vesicles (EVs), membrane-enveloped particles derived from cells and able to transport proteins and nucleic acids; ii) novel neuroregeneration-associated proteins. Based on these results, CirBrain aims to determine a more precise CSF kinetics of changes in: 1) EV size and number by tunable resistive puls sensing; 2) EV morphology and protein content by immunogold staining and electron microscopy; 3) EV subpopulations by size-exclusion chromatography followed by slot-blot immunoanalysis; 4) levels of neuroregeneration- associated proteins by targeted mass spectrometry; 5) microRNA content by real-time PCR. The biomarkers with the highest CSF levels detected in the first phase will be further analysed in plasma as part of the second CirBrain phase.CirBrain is expected to give new insights into identity and kinetics of circulating biomarkers for neurorecovery after TBI. Moreover, biomarkers based on CSF and blood, might enable non-invasive monitoring of neurorecovery not only in TBI, but also in diverse brain pathologies, providing evaluation of how different treatments affect brain recovery.]]></summary_en></project><project>
<id>9310</id><title_hr><![CDATA[Zdravstvena zaštita kao javni prostor: Društvena integracija i društvena različitost u kontekstu dostupnosti zdravstvene zaštite u Europi]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4099</user_id><user_firstLast_name>Amir Muzur</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-5194</code><acronim><![CDATA[]]></acronim><duration>01.10.2020 - 30.09.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Medicine]]></institution_en><team_members_id>861743</team_members_id><team_members_names><![CDATA[ Doktorand: Ivana Tutić Grokša ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>9314</id><title_hr><![CDATA[Istraživanje farmaceutskog ekspozoma slatkovodnih organizama - procjena rizika i prioritizacija]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3673</user_id><user_firstLast_name>Senka Terzić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-9250</code><acronim><![CDATA[PHARMA-RISK]]></acronim><duration>03.11.2020 - 17.09.2026</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Interdisciplinarne prirodne znanosti, </scie_field_hr><scie_field_en>Interdisciplinary natural sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>857298</team_members_id><team_members_names><![CDATA[ Doktorand: Klaudija Ivanković ]]></team_members_names><keywords_hr><![CDATA[farmaceutski spojevi, slatkovodni organizmi, riba, bioakumulacija, metabolizam, sediment, voda, LC-MS, prioritizacija, procjena rizika, rijeka Sava]]></keywords_hr><keywords_en><![CDATA[pharmaceutical compounds, freshwater organisms, fish, bioaccumulation, metabolism,  sediment, water, LC-MS, proritization, risk assessment, Sava river]]></keywords_en><summary_hr><![CDATA[U posljednjih dvadeset godina farmaceutski spojevi su prepoznati kao važna kategorija zagađivala. Postojeća literatura pretežno je usmjerena na istraživanje pojavnosti i ponašanja farmaceutskih spojeva u abiotičkim matricama (npr. voda i sediment), dok su radovi o njihovim koncentracijama u vodenim organizmima još uvijek srazmjerno rijetki. Ta je situacija u suprotnosti s činjenicom da koncentracije farmaceutskih spojeva u vodi i sedimentu predstavljaju samo indirektnu mjeru njihove potencijalne toksičnosti, dok interne koncentracije tih tvari u vodenim organizmima određuju njihov stvarni potencijal za izazivanje štetnih posljedica. U skladu s tim, svrha ovog projekta je dobivanje novih uvida u bioakumulaciju i metaboličko ponašanje odabranih farmaceutskih spojeva u slatkovodnim organizmima, s ciljem unaprjeđenja procjene rizika izloženosti ovim zagađivalima i njihove znanstveno utemeljene prioritizacije. Plan projekta uključuje nekoliko međusobno povezanih koraka, od razvoja metoda preko provedbe laboratorijski kontroliranih modelnih pokusa do terenskih istraživanja. U prvoj fazi razvit će se i validirati visokospecifične multirezidualne analitičke metode za kvantitativno određivanje tragova odabranih farmaceutskih tvari u različitim tipovima okolišnih uzoraka (biota, sediment, voda). Te će metode biti upotrijebljene u pažljivo isplaniranim modelnim i terenskim istraživanjima usmjerenim na određivanje farmaceutskog ekspozoma slatkovodnih riba. Modelni bioakumulacijski pokusi provest će se na zebricama (Danio rerio), uz primjenu različitih uvjeta izlaganja farmaceutskim tvarima. Biokemijski učinci izlaganja odredit će se na temelju praćenja indukcije glavnih detoksifikacijskih enzima u sustavu citokroma P450. U završnoj fazi projekta provest će se terensko istraživanje u rijeci Savi. Dobiveni podatci bit će upotrijebljeni za procjenu okolišne relevantnosti rezultata modelnih pokusa te za prioritizaciju zagađivala farmaceutskog porijekla u savskom bazenu.]]></summary_hr><summary_en><![CDATA[The problem of environmental contamination with pharmaceutical chemicals has been widely recognised over the past 20 years. The current literature is strongly dominated by studies focused at assessing the exposure concentrations in abiotic matrices (e.g. water and sediments) while the reports on the pharmaceutical concentrations in aquatic organisms remain comparatively scarce. However, when considering the possible biological effects, the aqueous exposure concentrations are only an indirect measure of potential toxicity, while the key parameter which determines the substance&#39;s potential for adverse effects is its internal concentration in the organism. Consequently, this project aims to provide new insights into the bioaccumulation and metabolic behaviour of pharmaceuticals in freshwater organisms, which is essential for an improved risk assessment of these contaminants as well as for their scientifically-sound prioritization. The project plan includes several interconnected phases, from method development and laboratory-controlled exposure experiments to field studies. Highly specific analytical methods for quantitative multiresidue determination of trace levels of selected pharmaceutical compounds in different environmental matrices (biota, water, sediment) will be developed and validated. These methods will be applied in carefully planned model and field experiments focusing on the characterization of pharmaceutical exposome in freshwater fish. The model bioaccumulation experiments will be performed using zebrafish (Danio rerio) as target organism, while considering different exposure scenarios. The biochemical responses in fish will be followed by measuring induction of the major cytochrome P450 detoxification enzymes. As its final step, the project includes a ground-truthing study in the Sava River to assess the environmental relevance of the pharmaceutical exposome and to collect the critical data for prioritization of individual pharmaceutical contaminants.]]></summary_en></project><project>
<id>9316</id><title_hr><![CDATA[Nove građevne jedinke u supramolekulskom dizajnu složenih višekomponentnih molekulskih kristala temeljenih na halogenskim vezama]]></title_hr><title_en><![CDATA[]]></title_en><user_id>356</user_id><user_firstLast_name>Dominik Cinčić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-4368</code><acronim><![CDATA[HaloBond]]></acronim><duration>09.11.2020 - 13.06.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>29303</team_members_id><team_members_names><![CDATA[ Doktorand: Nea Baus Topić ]]></team_members_names><keywords_hr><![CDATA[Halogenska veza, metaloorganski materijali, kokristali, supramolekulska kemija, mehanosinteza]]></keywords_hr><keywords_en><![CDATA[Halogen bond, metal-organic materials, cocrystals, supramolecular chemistry, mechanosynthesis]]></keywords_en><summary_hr><![CDATA[Halogenska veza je privlačna interakcija koja se intenzivno proučava u različitim područjima kemije, a ponajviše u kristalnom inženjerstvu. Za sustavno istraživanje halogenskih veza najčešće su primjenjivani organski sustavi s perhalogeniranim spojevima kao donorima halogenske veze, dok su najčešće korišteni akceptori organski spojevi koji sadrže različite funkcijske skupine s dušikom. Skupine s kisikom ili težim atomima kao akceptorima rjeđe su izučavane, a uključuju najviše spojeve sa sumporom te halogenima. Kao nastavak naših ranijih istraživanja u području kristalnog inženjerstva, kojima je uspostavljen preliminarni dizajn kokristala farmaceutskih spojeva temeljnih na halogenskoj vezi te prvi primjeri halogenske veze s teškim pniktogenima (P, As, Sb), ovaj projekt inovira dizajn i sintezu materijala temeljenih na halogenskim vezama te uključuje organsku, koordinacijsku i supramolekulsku kemiju. Projekt se sastoji od tri radne cjeline kojima je zajedničko izučavanje halogenskih veza, dizajn i sinteza: i) ionskih, ii) organskih te iii) metaloorganskih kokristala. Omogućit će: i) razjašnjavanje hijerarhije međumolekulskih interakcija u ionskim kristalima koji se temelje na halogenskoj vezi, ii) otkrivanje novih sintona halogenske veze te razumijevanje njihove fleksibilnosti, iii) istraživanje potencijala anorganskih i organskih aniona kao akceptora, iv) istraživanje potencijala kationskih vrsta kao donora i v) utvrđivanje potencijala težih pniktogena kao akceptora halogenske veze. Očekivani doprinos ovog projekta ponajviše je od fundamentalnog značaja za kristalno inženjerstvo kao i za eksperimentalnu i teorijsku supramolekulsku kemiju u čvrstom stanju. Značajni doprinosi bit će novi smjerovi za pouzdanu sintezu metaloorganskih materijala povezanih halogenskim vezama te u otvaranju novih mogućnosti korištenja halogenskih veza u dizajnu kokristala, višekomponentnih materijala od velikog interesa za razvoj lijekova, agrokemikalija i drugih funkcionalnih materijala.]]></summary_hr><summary_en><![CDATA[The halogen bond (X-bond) is emerging as an attractive interaction, intensely researched across different fields, and especially crystal engineering. Systematic studies of X-bonds are mostly performed using perhalogenated organic compounds as donors, using predominatly nitrogen-based acceptors. Studies with heavier atoms or oxygen as acceptors are less common, largely based on sulphur or halogens. As a continuation of our previous work in crystal engineering, which established preliminary designs for X-bonded pharmaceuticals and demonstrated the first examples of X-bonds to heavy pnictogen acceptors (P, As, Sb), this project will innovate the design and synthesis of materials based on X-bonds, by establishing ways to reliably combine coordination, covalent and supramolecular chemistry. The project is based on 3 work packages focusing on the design and synthesis of: i) ionic, ii) organic, and iii) metal-organic cocrystals. It will contribute by: i) elucidating the hierarchy of supramolecular interactions in X-bonded ionic crystals, ii) discovering new X-bonding synthons and understanding their flexibility, iii) investigating the potential of organic and inorganic anions as acceptors, iv) investigating the potential of cations as donors, and v) establishing the crystal engineering potential of heavy pnictogens as X-bond acceptors. Significant contributions will be new paths for reliable construction of metal-organic materials via X-bonds, and cocrystal-based routes for targeted synthesis of isostructural solids. The expected impact is in fundamental aspects of crystal engineering, as well as experimental and theoretical supramolecular chemistry of solids. The importance lies in opening new opportunities for using X-bonds in the design of cocrystals, i.e. multi-component materials of high interest in developing new pharmaceuticals, agrochemicals, and other functional advanced materials.]]></summary_en></project><project>
<id>9317</id><title_hr><![CDATA[Mapiranje parlamentarnih izbora 1848. – 1918. u Hrvatskoj]]></title_hr><title_en><![CDATA[]]></title_en><user_id>461</user_id><user_firstLast_name>Stjepan Matković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-4898</code><acronim><![CDATA[MAPPAR]]></acronim><duration>28.07.2020 - 27.01.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Povijest, </scie_field_hr><scie_field_en>History, </scie_field_en><institution_hr><![CDATA[Hrvatski institut za povijest]]></institution_hr><institution_en><![CDATA[Croatian Institute of History]]></institution_en><team_members_id>21408</team_members_id><team_members_names><![CDATA[ Doktorand: Goran Ovčariček ]]></team_members_names><keywords_hr><![CDATA[mapiranje, parlamentarni izbori, parlament, izbornici, Hrvatska, Vojna krajina, Habsburška Monarhija]]></keywords_hr><keywords_en><![CDATA[Mapping, Parliamentary Elections, Parliament, Electors, Croatia, Military Frontier, Habsburg Monarchy]]></keywords_en><summary_hr><![CDATA[Glavni istraživački cilj ovoga projekta jest na hrvatskom primjeru sustavno istražiti i mapirati parlamentarne izbore od uvođenja Sabora kao modernoga, jednodomnog predstavničkog tijela (1848) do sloma Austro-Ugarske (1918). Izbori su tada služili kao središnji način političkog izražavanja na nacionalnim i lokalnim razinama. Istraživanje obuhvaća područje Kraljevine Hrvatske i Slavonije, koje bi se, u određenoj mjeri, kompariralo s izbornim rezultatima u Dalmaciji, gdje se primjenjivao austrijski tip izbornoga prava s kurijalnim sustavom. U dosadašnjim historiografskim radovima nekoliko je autora pisalo o povijesti hrvatskoga parlamentarizma u sklopu multinacionalne zajednice naroda u Habsburškoj Monarhiji. U njima su, s obzirom na promatranje izbornih rezultata za Hrvatski sabor isključivo kao pokazatelja trenutačnih političkih ozračja za stvaranje stranačko-političkoga pejzaža, središnje mjesto zauzimali zbirni pregledi rezultata pojedinih saborskih izbora, a naglasak je stavljen na ispitivanje stranačkih ideologija i ustavnih pitanja. Na taj su način izostale sustavne analize izbora, koje bi ukazale na više bitnih čimbenika: izborne zakone, izborne reforme, izborne kampanje, strukture izbornih jedinica i izborništva (izborne geometrije), stranačke organizacije i biografske analize saborskih zastupnika u funkciji ispitivanja političkih elita. Osim toga, preliminarna istraživanja pokazuju da se u iznesenim pregledima pojavljuju neispravni podatci i da se nije vodilo računa o više specifičnih pojedinosti vezanih uz izborne zakone, poput dopunskih izbora ili verifikacije izbornih mandata. Stoga je zadaća ovoga projekta cjelovito sagledati izbornu povijest i ispraviti navedene propuste kako bi se dobila pouzdana baza podataka o saborskim zastupnicima i njihovim izbornim tijelima. ]]></summary_hr><summary_en><![CDATA[The main research objective of this project is to systematically investigate and map parliamentary elections on the Croatian example from the introduction of the Parliament as a modern, one chamber representative body (1848) until the dissolution of the Habsburg Monarchy (1918). In that period elections served as the basic way of political expression at national and local levels. The research covers the territory of the Kingdom of Croatia and Slavonia, which will be, to some extent, compared with election results in Dalmatia, where the Austrian type of electoral rights with a curial system was used. In previous history works, only a few authors wrote about Croatian parliamentarian history within the multinational framework of the Habsburg Monarchy. Starting from the fact that the electoral results for the Croatian Parliament were observed solely as indicators of the current political climate for the creation of a party-political landscape, the central place in the investigations thus far was a survey of the results of parliamentary elections, with an emphasis on party ideologies and constitutional issues. Up to now, there was neither a systematic analysis of the elections nor of other important factors such as: election laws, electoral reform, election campaign, electoral constituencies, manipulations (gerrymandering), and electoral structure (election geometry), party organizations and biographical analysis of parliamentary deputies as an integral part of political elites. In addition, preliminary research shows that erroneous data appear in the literature and that no more specific details of by-elections or the verification of election mandates have been taken into account. Therefore, the task of this project is to comprehensively review the electoral history and correct these omissions in order to obtain a reliable database on parliamentary representatives and their electoral bodies.]]></summary_en></project><project>
<id>9318</id><title_hr><![CDATA[Nelokalni mehanički modeli nanogreda]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3419</user_id><user_firstLast_name>Marko Čanađija</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-2038</code><acronim><![CDATA[nonNano]]></acronim><duration>11.11.2020 - 10.11.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Temeljne tehničke znanosti, </scie_field_hr><scie_field_en>Basic engineering sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Tehnički fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Engineering]]></institution_en><team_members_id>858399</team_members_id><team_members_names><![CDATA[ Doktorand: Valentina Košmerl ]]></team_members_names><keywords_hr><![CDATA[nanogrede, nelokalna mehanika, nanosenzori, konačni elementi, integracijska formulacija, ugljične nanocijevi]]></keywords_hr><keywords_en><![CDATA[nanobeams, nonlocal mechanics, nanosensors, finite elements, integral formulation, carbon nanotubes]]></keywords_en><summary_hr><![CDATA[Predloženim istraživanjem razvit će se napredni nelokalni modeli nanogreda, a koji će biti prikladni za provođenje realističnih simulacija mehaničkog ponašanja nanostruktura. Naime, velika većina rezultata predstavljenih u literaturi uključuje određenje manjkavosti. U tom smislu valja istaći dva problema. Često korištena nelokalna gredna formulacija temeljena na gradijentnim metodama daje paradoksalne rezultate u nekim osnovnim problemima. Drugi je problem povezan s mehaničkim značajkama koje su potrebne radi dobivanja rezultata usporedivih s eksperimentima odnosno simulacijama provedenim pomoću molekularne dinamike. Pritom se kao najvažnija mehanička značajka može istaći nelokalni parametar. Točna vrijednost nelokalnog parametra za pojedine materijale uključuje mnoštvo nesigurnosti. Da bi se nadišlo gore opisane paradokse, koristit će se integracijska formulacija temeljena na naprezanjima. Ovo je novi i obećavajući pristup koji nema spomenute poteškoće. Što se pak tiče realističnog mehaničkog ponašanja, da bi se postigao takav cilj mora se uzeti u obzir i diskretnu prirodu nanostruktura. U tom smislu, izotermni procesi deformiranja nanogreda predstavljat će ishodišnu točku, no fokus će biti na neizotermičim problemima. U prvom redu, u tom kontekstu razmatrat će se važna proširenja na dinamičko ponašanje, kao i na kompozitne nanogrede. Razvijene formulacije bit će iskorištene za razvoj novog nelokalnog grednog konačnog elementa koji će biti ugrađen u softver za analizu konačnim elementima Simulia/Abaqus. Novi konačni element omogućit će provođenje niza simulacija s ciljem dobivanja topološki optimalnih struktura s ciljanim značajkama.]]></summary_hr><summary_en><![CDATA[The proposal at hand aims to develop advanced nonlocal models of nanobeams suitable for more realistic simulation of mechanical behavior of nanostructures. Motivation for this research arises from several shortcomings in majority of results presented in the literature. Two of them have to be pointed out. A widely used gradient based beam nonlocal formulations are prone to paradoxical results if applied to some of basic bending problems. The other problem is related to mechanical properties that are needed in order to obtain similar results like those obtained experimentally or by molecular dynamics simulations. The most important mechanical property is the nonlocal parameter, but its precise value for a certain material still encompasses a lot of uncertainties. In order to overcome mentioned paradoxes, the stress-driven integral formulation will be used. This is a novel and promising approach, not suffering from above described problems. As for the realistic mechanical behavior, in order to reach such a goal, the discrete nature of nanostructures must be accounted for. Although isothermal deformation of nanobeams will be the starting point, the focus will be on the nonisothermal processes. In particular, those will include important extensions to dynamical effects, as well as to composite materials. The formulations obtained in such manner will be used to develop a novel nonlocal beam finite element that will be implemented into finite element software Simulia/Abaqus. With new finite element, a series of simulations will be performed in order to obtain topologically optimal structures with tailored properties.]]></summary_en></project><project>
<id>9319</id><title_hr><![CDATA[Koordinacijske reakcije makrocikličkih liganada u otopini]]></title_hr><title_en><![CDATA[]]></title_en><user_id>12733</user_id><user_firstLast_name>Nikola Bregović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-3999</code><acronim><![CDATA[MacroSol]]></acronim><duration>15.01.2021 - 14.07.2025</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>863818</team_members_id><team_members_names><![CDATA[ Doktorand: Marija Cvetnić ]]></team_members_names><keywords_hr><![CDATA[supramolekulska kemija, receptori, termodinamika, solvatacija, kaliksareni, ciklopeptidi, ciklodekstrini, kukurbiturili]]></keywords_hr><keywords_en><![CDATA[supramolecular chemistry, receptors, thermodynamics, solvation, calixarenes, cyclopeptides, cyclodextrins, cucurbiturils]]></keywords_en><summary_hr><![CDATA[Makrociklički spojevi zasigurno spadaju među najvažnije supramolekulske receptore aniona, kationa i neutralnih molekula. Ovaj će se projekt usmjeriti k dizajnu i sintezi brojnih takvih liganada, kao i detaljnoj fizikalno-kemijskoj karakterizaciji njihovih reakcija u otopini. Priredit će se niz derivata kaliksarena s različitim brojem supstituiranih fenolnih podjedinica. Ti će spojevi biti predvidivo vrlo efikasni i selektivni senzori za katione alkalijskih i zemnoalkalijskih metala te lantanoida, kao i raznih anionskih vrsta. Također će se istražiti reakcije receptora temeljenih na ciklodekstrinima i kukurbiturilima s različitim neutralnim supstratima. Predviđena istraživanja uključuju i veću skupinu ciklopeptida koji su prvenstveno zamišljeni kao receptori aniona. Neki od spomenutih liganada trebali bi biti iznimno osjetljivi fluorescentni senzori, a posebna pažnja bit će posvećena dizajnu receptora sa zadovoljavajućom topljivošću u vodi. Koordinacijske reakcije navedenih spojeva s raznim supstratima u nizu otapala detaljno će se proučiti sveobuhvatnim pristupom koji uključuje termodinamička, komputacijska i strukturna istraživanja. Koristit će se razne eksperimentalne metode, poput mikrokalorimetrije, UV-Vis spektrofotometrije, fluorimetrije, spektroskopije NMR, konduktometrije, potenciometrije i rentgenske strukturne analize. Receptori i njihovi kompleksi bit će također istraženi primjenom molekulske dinamike i drugih računalnih metoda. Takav pristup omogućit će pouzdano određivanje termodinamičkih veličina (konstante stabilnosti, standardne Gibbsove energije, entalpije i entropije reakcija kompleksiranja i otapanja) te dobivanje niza strukturnih informacija. Posebna će pažnja biti posvećena utvrđivanju utjecaja stvaranja vodikovih veza i solvatacije reaktanata i produkata na ravnoteže reakcija kompleksiranja. Prikupljeni termodinamički podatci trebali bi omogućiti vrlo detaljan uvid u ključne čimbenike koji određuju ravnotežni doseg istraživanih reakcija. ]]></summary_hr><summary_en><![CDATA[The efficient and selective macrocyclic receptors for charged and neutral species have played a key role in the development of supramolecular chemistry over the last few decades. This project will focus on the design and synthesis of a variety of such compounds as well as detailed physicochemical characterization of their reactions in solution. A series of calixarene derivatives with diverse number of substituted phenolic subunits will be prepared with the aim of obtaining the ligands which are capable of strongly and selectively binding alkaline, alkaline earth and lanthanide metal cations, and different kinds of anions. The receptors based on cyclodextrins and cucurbiturils and their reactions with several neutral guests will be explored as well. The investigation will also include a number of cyclopeptide derivatives primarily being designed as anion receptors. Some of the above mentioned compounds are envisaged to be highly efficient fluorescent receptors and/or to be water-soluble. The complexation abilities of all mentioned ligands towards various substrates in many solvents will be explored by using an integrated approach which includes thermodynamic, computational, and structural studies. A number of experimental methods (microcalorimetry, UV-Vis spectrophotometry, fluorimetry, NMR spectroscopy, conductometry, potentiometry, X-ray diffraction) as well as molecular dynamics and other computational techniques will be employed. Such an approach will yield detailed and reliable thermodynamic quantities (stability constants, reaction and solution Gibbs energies, enthalpies, and entropies) and the structural information regarding the receptors and their complexes. Particular attention will be paid to the hydrogen-bonding and solvent effects on the equilibria of binding reactions. The obtained thermodynamic and structural information will provide a detailed insight into the main factors governing the studied complexation processes.]]></summary_en></project><project>
<id>9320</id><title_hr><![CDATA[Socijalno-ekološki izazovi ruralnog razvoja: objektivni i subjektivni pokazatelji otpornosti hrvatskih ruralnih socijalno-ekoloških sustava]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5335</user_id><user_firstLast_name>Tijana Trako Poljak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-1378</code><acronim><![CDATA[SECRURAL]]></acronim><duration>19.10.2020 - 18.10.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Sociologija, </scie_field_hr><scie_field_en>Sociology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>858328</team_members_id><team_members_names><![CDATA[ Doktorand: Bruno Šimac ]]></team_members_names><keywords_hr><![CDATA[ruralni socijalno-ekološki sustav, indeks ruralne razvijenosti, prilagodljivost, objektivni pokazatelji otpornosti, subjektivni pokazatelji otpornosti]]></keywords_hr><keywords_en><![CDATA[rural socio-ecological system, rural development index, adaptability, objective indicators of resilience, subjective indicators of resilience]]></keywords_en><summary_hr><![CDATA[Glavni je cilj predloženog projekta utvrditi stanje razvijenosti hrvatskih ruralnih područja i kapacitet otpornosti socijalno-ekološkim izazovima na početku 21. st. Pritisci globalizacije, zajedno s realnošću ekološke krize, egzogeni su čimbenici koji nisu zaobišli ni hrvatska sela. Postsocijalističko nasljedovanje, ratna razaranja, tranzicija u demokratski liberalni sustav, te pristup Europskoj uniji, samo su neki od endogenih izazova perspektivama ruralnog razvoja. Međutim, danas kada ruralna područja zauzimaju ključno mjesto u međunarodnim razvojnim strategijama kao čuvari kulturnog i prirodnog bogatstva, u Hrvatskoj izostaju sustavna znanstvena istraživanja koja bi služila kao podsticaj za izradu strategija ruralnog razvoja prilagođenih hrvatskim okolnostima. Takve strategije mogu biti učinkovite i samo ako se ruralna područja i stanovništvo počnu razumijevati kao aktivni sudionici suvremenih kretanja. U istraživanju se stoga oslanjamo na nova znanja i metodologiju koja ruralna područja definiraju kao dinamične socijalno-ekološke sustave (RSES) s kapacitetima prilagodbe i otpornosti. Posebice se oslanjamo na autore koji uz objektivne pokazatelje otpornosti naglašavaju često zanemarenu subjektivnu dimenziju (socijalni, ljudski i kulturni kapital). U istraživanju ćemo koristiti mješovite metode istraživanja: 1) „desk“ metoda, kako bismo utvrdili objektivne pokazatelje otpornosti hrvatskih RSES-ova, 2) metoda ankete, kako bismo istražili subjektivne pokazatelje otpornosti hrvatskih RSES-ova na nacionalno reprezentativnom uzorku, te omogućili usporedbu međusobno i s urbanim sredinama, i 3) 200 intervjua s lokalnim stanovništvom i dionicima u 20 područja svih hrvatskih regija, kojima ćemo dubinskih istražiti subjektivnu dimenziju nošenja sa socijalno-ekološkim izazovima u svakodnevnom životu. Rezultat ovog sustavnog pristupa bit će izrađen i istražen model izračuna indeksa otpornosti hrvatskih ruralnih područja na temelju objektivnih i subjektivnih pokazatelja.]]></summary_hr><summary_en><![CDATA[The main goal of the project is to determine the current state of development of Croatian rural areas and their capacity for resilience against social-ecological challenges. Globalization processes, further aggravated by global ecological crisis, exert exogenous pressures on all parts of the world and Croatian rural areas are no exception. Post-socialist legacy, wartime destruction, transition to democratic liberal system, and accession to the European Union are just some of the endogenous challenges to the perspectives of rural development. However, while rural areas are regaining principal position in international developmental policies, there is a lack of systematic scientific research in Croatia that could inform national rural development strategies, which must be adapted to the local context. Furthermore, such strategies can only be successful if rural areas and their population are seen as active participants. In our research we, therefore, rely on new theoretical and methodological approaches, which define rural areas as dynamic social-ecological systems (RSES) with the capacity for adaptation and resilience. We especially rely on those authors who emphasize not only objective indicators of resilience but also focus on frequently neglected subjective dimension (social, cultural and human capital). In our research we will use mixed methodology: 1) desk research, to determine objective indicators of resilience of Croatian RSESs, 2) survey research, to examine subjective indicators of resilience of Croatian RSESs on a representative national sample, and enable comparison between them and with urban areas, and 3) 200 deep semi-structured interviews with local population and relevant actors across all Croatian regions, for an in-depth analysis of coping mechanisms in everyday lives. The overall result of the project will be a constructed and analyzed model for resilience index measurement for Croatian rural areas comprised of objective and subjective indicators.]]></summary_en></project><project>
<id>9321</id><title_hr><![CDATA[Multifaktorna analiza HPV inficiranih stanica u nastanku raka vrata maternice]]></title_hr><title_en><![CDATA[]]></title_en><user_id>898</user_id><user_firstLast_name>Ivan Sabol</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-6380</code><acronim><![CDATA[MACCD]]></acronim><duration>28.10.2020 - 27.04.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>858344</team_members_id><team_members_names><![CDATA[ Doktorand: Ena Pešut ]]></team_members_names><keywords_hr><![CDATA[HPV, masena citometrija, CyTOF, rak vrata maternice, biomarkeri]]></keywords_hr><keywords_en><![CDATA[HPV, mass cytometry, CyTOF, cervical cacner, biomarkers]]></keywords_en><summary_hr><![CDATA[Rak vrata maternice (RVM) je 4. rak u žena u svijetu te u Europi godišnje uzrokuje smrt oko 13.000 žena. Programi probira i cijepljenje protiv humanog papiloma virusa (HPV) nude značajnu zaštitu, no imaju specifične probleme. Cijepljenje je manje učinkovito ako se primjenjuje nakon izlaganja HPV-u, i ako se primjenjuje propisno, ne štiti od svih vrsta HPV-a koje uzrokuju RVM. Programi probira, ovisno o korištenoj metodi, citologiji ili HPV-testiranju, imaju ili smanjenu osjetljivost ili specifičnost, no još uvijek imaju visoke negativne prediktivne vrijednosti i u zemljama gdje se primjenjuju su se pokazali kao vrlo učinkoviti u smanjenju smrtnosti. Međutim, pozitivna prediktivna vrijednost (PPV) za otkrivanje žena s visokim rizikom razvoja RVM ostaje slaba, smanjujući efikasnost programa probira budući da se veliki broj žena upućuje na skupe zahvate koji možda i nisu nužni. Osim novčanih troškova, prekomjerno liječenje žena, često reproduktivne dobi, nosi rizike, a može dovesti i do komplikacija u trudnoći, uključujući pobačaj. Ovim projektom želimo istražiti panel od 30 staničnih biljega koji koreliraju s tijekom bolesti korištenjem najsuvremenije metode masene citometrije. Metoda omogućuje paralelnu identifikaciju biljega na pojedinačnim stanicama kombinacijom protočne citometrije i masene spektrometrije izotopa teških metala. Žene s različitim stupnjevima cervikalnih lezija (n=250) bit će uključene i praćene kroz 2 godine. Masenom citometrijom će se testirati najreprezentativnijih 100 uzoraka, kao i stanične linije RVM i normalnih stanica. Dobiveni podaci korelirat će se s promjenama cervikalnih lezija i promjenama u prisutnosti virusa kroz vrijeme. Obećavajući biljezi će se potvrditi imunocitokemijskim metodama na svim prikupljenim uzorcima. Pronalaženje biljega s visokom PPV otvorit će put za poboljšanje efikasnosti programa probira i time značajno ublažiti socioekonomski teret RVM a buduće pacijente poštedjeti prekomjernog rizika.]]></summary_hr><summary_en><![CDATA[Cervical cancer (CC) is the 4th cancer in women worldwide and even in Europe causing ~13,000 deaths annually. Although CC screening and human papillomavirus (HPV) vaccination offer significant protection, each has specific issues. Vaccination is ineffective if administered after HPV exposure, and even if offered according to recommendations, it does not protect against all HPV types causing CC. CC screening programmes, depending on the method used, cytology or HPV testing, have either reduced sensitivity or specificity, respectively, but still have high negative predictive values and effectively reduce mortality. Positive predictive value (PPV) for detecting women at high-risk of CC development, however, remains poor, making them less efficient since large number of women are referred to costly treatments that might not be needed. Besides costs, over-treating women, often of reproductive age, incurs treatment risks as well as complications in pregnancy including miscarriage. With this project, we aim to explore a panel of 30 potentially relevant cellular markers that are likely to correlate with disease course using state-of-the-art mass cytometry profiling. The method allows parallel identification of markers on single cells using a combination of flow cytometry and mass-spectrometry analysis of heavy metal isotope labels. Women with different stages of cervical lesions (n=250) will be enrolled and followed for up to 2 years. Mass cytometry will be done on best representative 100 patients as well as CC and normal cell lines. Resulting data will be correlated with cervical lesion and viral persistence changes. Potential biomarkers will be assessed by immunocytochemistry for validation on all collected samples. Finding biomarkers with high PPV will open the way for improving the efficacy of CC screening and thus significantly alleviate socioeconomic burden of CC as well as lessen the over-treatmetnt risks for future patients.]]></summary_en></project><project>
<id>9322</id><title_hr><![CDATA[IP-2019-04-7978 Strukturna kiralnost vs molekulska kiralnost]]></title_hr><title_en><![CDATA[]]></title_en><user_id>564</user_id><user_firstLast_name>Andreja Lesac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-7592</code><acronim><![CDATA[]]></acronim><duration>01.10.2020 - 30.09.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>856171</team_members_id><team_members_names><![CDATA[ Doktorand: Antonija Ožegović ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>9323</id><title_hr><![CDATA[Raspadi i vremena života teških hadrona]]></title_hr><title_en><![CDATA[]]></title_en><user_id>2665</user_id><user_firstLast_name>Blaženka Melić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-6272</code><acronim><![CDATA[HHDeLi]]></acronim><duration>17.02.2023 - 16.02.2027</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>866657</team_members_id><team_members_names><![CDATA[ Doktorand: Lovro Dulibić ]]></team_members_names><keywords_hr><![CDATA[teorijska fizika elementarnih cestica, fizika teških hadrona, razvoj po masama teškog kvarka, inkluzivni raspadi, vremena života]]></keywords_hr><keywords_en><![CDATA[theoretical particle physics, heavy hadron physics, heavy quark expansion, inclusive decays, lifetimes]]></keywords_en><summary_hr><![CDATA[Vremena života teških hadrona, kao temeljna svojstva čestica, se dobivaju izračunom inkluzivnih širina raspada teških kvarkova koji su sustavno obrađeni u konzistentnom okviru poznatom kao razvoj po masi teškog kvarka (eng.HQE). Budući da su vezana stanja teškog kvarka i lakih konstituenata (mezoni, jednostruki c-(šarmantni) ili b-(beauty) barioni) ili dva teška kvarka i jednog lakog (dvostruki c-(šarmantni)  ili b-(beauty )barioni), teški hadroni sadrže meke stupnjeve slobode koji generiraju neperturbativne korekcije koje je teško izračunati. Novi eksperimentalni podaci, kako o c-hadronskim raspadima tako i o b-raspadima, omogućili su detaljnu usporedbu eksperimentalnih i teorijskih rezultata i otkrili su dobro slaganje uz nekoliko značajnih iznimaka: nedavna mjerenja vremena života  Ksi(c)+, Ksi(cc)++ i osobito, Omega(c)0  bariona se ne slažu s teorijskim predviđanjima. Stoga je potrebno pažljivo ispitati sve dijelove izračuna i odrediti ih vrlo precizno. Posebice, masa teškog kvarka nije dobro definirana veličina. Drugi glavni izvor neodređenosti je vrijednost valne funkcije teškog hadrona koja parametrizira doprinos operatora dimenzije 6 i viših, te dovodi do glavnih razlika u vremenima života. Neodređenosti koje nadilaze ove “prirodne neodređenosti ” smatraju se narušenjima kvark-hadronske dualnosti. Budući da je inverzna masa b-kvarka dobar parametar razvoja u raspadima b-hadrona, šarmantni hadronski raspadi ostaju kao najpogodniji za proučavanje i ispitivanje mogućeg narušenja kvark-hadronske dualnosti. Međutim, da bismo mogli razumjeti složenost barionskih valnih funkcija, b-barionski raspadi također mogu pružiti vrijedne informacije. Zbog svih gore navedenih činjenica, potrebno je ponovno detaljno razmotriti izračun vremena života teških hadrona i utvrditi pouzdane metode i modele koji se koriste u izračunu.]]></summary_hr><summary_en><![CDATA[The lifetimes of heavy hadrons, being the fundamental particle’s property, are obtained by calculating inclusive decays of heavy quarks which are  systematically treated in a consistent framework known as the heavy-quark expansion, HQE. Being the bound states of a heavy quark and light constituent (mesons, singly charmed/beauty baryons) or of two heavy quarks and one light constituent (doubly charmed/beauty baryons), heavy hadrons contain soft degrees of freedom which generate nonperturbative power corrections which are difficult to calculate. New experimental data, both on c-hadron decays and on b-decays, have made possible a detailed comparison of experimental and theoretical results and have revealed broad agreement with several notable exceptions: recent measurements of the Ksi(c)+, Ksi(cc)++ and in particular Omega(c)0  lifetimes do not agree with theoretical predictions. Therefore, one has to examine all ingredients of the calculation very carefully and to calculate them very precisely. In particular, the heavy quark mass is not a well defined quantity. The other main source of uncertainty is the value of the heavy hadron wave function which parametrizes the contribution of  dimension-6 operators and higher and leads to the main differences in the lifetimes. The uncertainties beyond these “natural uncertainties” are considered to be violations of quark-hadron duality. Since the inverse beauty quark mass appears to be a good expansion parameter in beauty decays the charmed hadron decays are left as a playground for studying and testing of the possible violation of the quark-hadron duality. However, to be able to understand the complexity of baryonic wave functions, the beauty baryon decays can provide valuable information too. Due to the all facts said above, it is timely to revisit the calculation of the heavy hadron lifetimes and to establish the reliable methods and models used in the calculation.]]></summary_en></project><project>
<id>9325</id><title_hr><![CDATA[Interakcija nositelj-parazit: odnos tri različita tipa nositelja prema invaziji metiljem Fascioloides magna]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6172</user_id><user_firstLast_name>Ana Galov</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-1385</code><acronim><![CDATA[MAGNA]]></acronim><duration>02.11.2020 - 30.04.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>858367</team_members_id><team_members_names><![CDATA[ Doktorand: Ida Svetličić ]]></team_members_names><keywords_hr><![CDATA[Fascioloides magna, interakcija nositelj-parazit, srna obična, jelen obični, divlja svinja]]></keywords_hr><keywords_en><![CDATA[Fascioloides magna, host-parasite interaction, roe deer, red deer, wild boar]]></keywords_en><summary_hr><![CDATA[Fascioloidoza je invazijska bolest uzrokovana sa za Europu nezavičajnom vrstom dvorodnog metilja Fascioloides magna. Za sada je moguće razlikovati tri tipa konačnih divljih nositelja ovog metilja u Europi: tipični (jelen obični i lopatar), &#39;&#39;slijepa ulica&#39;&#39; (svinja divlja) i atipični (srna obična, muflon i divokoza). Iako je pojava ovog parazita potaknula razmjerno velik interes znanstvene javnosti rezultirajući objavom brojnih znanstvenih članaka, interakcije nositelj-parazit i dalje nisu razjašnjene. Pri tome je fascioloidoza atipičnih nositelja često smrtonosna bolest te je na invadiranim područjima zabilježen pad brojnosti srna. Cilj je razumijevanje interakcije nositelj-parazit u različitim tipovima nositelja. Pretpostavke projekta su: i) trajna migracija metilja kroz jetru nositelja je posljedica neadekvatnog imunosnog odgovora nositelja, i ii) trajna migracija metilja kroz jetru nositelja posljedica je nemogućnosti spolnog sazrijevanja metilja. Ciljevi projekta su: a) proučiti makroskopske i mikorskopske promjene na i u jetrima različitih tipova nositelja, b) razumjeti imunosni odgovor na metilja F. magna kod različitih nositelja, c) usporediti raznolikost/postojanje specifičnih alela MHC gena kod različitih tipova nositelja, d) analizirati različite stadije metilja kod različitih nositelja. Uzorci krvi, čitave jetre i metilji prikupit će se tijekom redovitih lovnih zahvata. Jedinke ćemo razvrstavati na negativne, invadirane, ponovno invadirane i  izliječene. Životinje s područja na kojima nije utvrđena fascioloidoza će poslužiti kao potpuno negativne kontrole. Prikupljene uzorke analizirat ćemo parazitološki, omika metodama, NGS i klasičnom analizom MHC gena, seciranjem metilja. Analize će provesti tim oformljen tijekom provedbe uspostavnog istraživačkog projekta uz pomoć članova projekta ERA Chairs  za dio proteomike. Očekujemo da će rezultati projekta pružiti odgovore o značajnim interakcijama između nositelja i parazita na primjeru fascioloidoze.]]></summary_hr><summary_en><![CDATA[Fascioloidosis is parasitic disease caused by to Europe non-native digenean trematode Fascioloides magna. For now, three different types of final hosts can be recognized in Europe: definitive (red and fallow deer), dead-end (wild boar) and aberrant (roe deer, mouflon, chamois). Despite the fact that this parasite caused significant scientific interest resulting in numerous publications, host-parasite interactions remains unclear. Since fascioloidosis in aberrant hosts often causes mortality, a decline in roe deer population was observed on infected areas. The aim is to understand the mechanisms of host-parasite interactions in different types of hosts. Project hypothesis are: i) the continuing migration of a parasite is a result of inadequate host immune response, and ii) the continuing migration of a parasite is a result of its inability to reach sexual maturation. Project goals are: a) to analyse gross and microscopic liver lesions in different types of hosts, b) to understand immune responses to F. magna in different types of host, c) to compare variability/presence of the specific alleles of the MHC genes in different types of hosts, d) to analyse different stages of the flukes in different types of hosts. Samples of blood, whole livers and flukes will be collected following regular hunting operations. Animals will be classified as negative, infected, reinfected and cured. Animals from disease free areas will be used as full negative controls. Methods applied to achieve project goals include parasitological analysis, whole proteome analysis, classical approach and NGS for exon 2 of MHC class II loci analysis, fluke dissection. The analysis will be performed by the team formed during the installation grant, strengthen by ERA Chairs member for proteomic analysis. The deliverables of the proposed project should provide answers for important host-pathogen interactions in fascioloidosis. ]]></summary_en></project><project>
<id>9326</id><title_hr><![CDATA[Podpovršinski preferencijalni transportni procesi u poljoprivrednim padinskim tlima]]></title_hr><title_en><![CDATA[]]></title_en><user_id>20438</user_id><user_firstLast_name>Vilim Filipović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-4874</code><acronim><![CDATA[SUPREHILL]]></acronim><duration>21.09.2020 - 20.09.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Interdisciplinarne biotehničke znanosti, </scie_field_hr><scie_field_en>Interdisciplinary biotechnical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Agronomski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Agriculture]]></institution_en><team_members_id>856048</team_members_id><team_members_names><![CDATA[ Doktorand: Jasmina Defterdarović ]]></team_members_names><keywords_hr><![CDATA[hidropedologija, agrokemikalije, vadozna zona tla, lizimetri, preferencijalni tok, numerički modeli, opservatorij kritične zone]]></keywords_hr><keywords_en><![CDATA[hydropedology, agrochemicals, soil vadose zone, preferential flow, lysimeters, numerical models, critical zone observatory]]></keywords_en><summary_hr><![CDATA[Padinska poljoprivredna tla karakteriziraju značajne lokalne heterogenosti zbog kojih se javljaju procesi preferencijalnog toka vode u tlu te posljedično, neujednačeno vlaženje tla i nelinearni pronos agrokemikalija (gnojiva i pesticida). Primjer navedenih procesa, a koji se osobito negativno odražavaju na kvalitetu tla i vodnih resursa, su površinsko otjecanje, erozija, vertikalni pronos (procjeđivanje), podpovršinski preferencijalni tok te nelinearno ponašanje kemikalija; svi pod dodatnim utjecajem korijena biljke i evapotranspiracije. Stoga se kritična (nesaturirana) zona padinskih tala, smještena između površine tla i podzemne vode, smatra jednim od najsloženijih terestričkih sustava na Zemlji. Glavni cilj projekta SUPREHILL formiranje je istraživačke grupe i opservatorija kritične zone za praćenje procesa pronosa tvari na padinskim terenima kako bi se mogao kvantificirati podpovršinski preferencijalni tok vode i nelinearni pronos agrokemikalija. U istraživanju će se koristiti oprema za praćenje stanja na terenu u kombinaciji s laboratorijskim i numeričkim kvantifikacijskim metodama. Poljski će pokus biti opremljen senzorima za mjerenje vodne bilance, klimatskom stanicom te težinskim lizimetrima s neporušenim tlom u svrhu mjerenja izotopa vode, trasera, nitrata, otopljenog organskog ugljika te insekticida na bazi bakra u sustavu tlo-biljka-atmosfera. Interdisciplinarnim će se pristupom omogućiti kvantifikacija nelinearnih procesa u tlu, posebice toka vode i pronosa agrokemikalija. Detaljno praćenje procesa rezultirati će velikom bazom podataka koja će se koristiti za kalibraciju numeričkih modela te za razvoj novih postupaka modeliranja. Rezultati će se moći upotrijebiti za prilagodbu gospodarenja padinskim poljoprivrednim površinama, omogućavajući učinkovitije korištenje vode, hranjiva i pesticida. Također, cilj projekta jest uključivanje u inicijativu europske mreže lizimetara, što će osigurati buduće proširivanje istraživanja.]]></summary_hr><summary_en><![CDATA[Hillslope agricultural soils are characterized by local scale heterogeneities which can trigger preferential transport processes and result in uneven wetting of soil and a non-linear transport of agrochemicals (e.g., fertilizers, pesticides). Negative impact on soil and water resources may originate from these processes, e.g., from surface runoff, erosion, vertical leaching, subsurface preferential flow, nonlinear chemical behavior; also affected by crop uptake and evapotranspiration. Therefore, hillslope soil critical (vadose) zone, located between the soil surface and groundwater, is considered as one of the most complex terrestrial systems. The main objective of SUPREHILL project is to form a new research group and to set up critical zone observatory of transport processes in hillslope soils, aiming to quantify subsurface preferential flow and a nonlinear agrochemical transport. Research will be focused on local scale subsurface processes in soil and performed using field monitoring equipment combined with laboratory and numerical quantification methods. The experimental site will be equipped with a range of sensors for water balance measurements, climatic station and undisturbed weighable field lysimeters for measuring water isotopes, tracers, nitrates, dissolved organic carbon and copper-based insecticides in a soil-plant-atmosphere system. Interdisciplinary approach will ensure quantification of non-linear processes in hillslope soils, especially regarding the soil water flow and agrochemical dynamics. Precise monitoring will produce a large database, later used for numerical model calibration and development of novel modeling procedures. Results can be used for the adjustment of management practices at sloped agricultural sites, leading to more efficient use of water, nutrients and pesticides. Project objective is also to become a part of the Europe-wide lysimeter network initiative, allowing the expansion of the observatory focus through new research topics.]]></summary_en></project><project>
<id>9327</id><title_hr><![CDATA[Nanoemulzije unaprijeđene biofarmaceutske vrijednosti za liječenje bolesti suhoga oka]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4075</user_id><user_firstLast_name>Jasmina Lovrić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-4932</code><acronim><![CDATA[BeatDED]]></acronim><duration>16.11.2020 - 14.09.2023</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Farmacija, </scie_field_hr><scie_field_en>Pharmaceutical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Farmaceutsko-biokemijski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Pharmacy and Biochemistry]]></institution_en><team_members_id>861730</team_members_id><team_members_names><![CDATA[ Doktorand: Josip Ljubica ]]></team_members_names><keywords_hr><![CDATA[bolest suhog oka, nanoemulzije, in vitro biorelevantne metode, razvoj formulacije, biofarmaceutska karakterizacija, oftlamička primjena lijekova]]></keywords_hr><keywords_en><![CDATA[dry eye disease, nano emulsions, in vitro biorelevant methods, formulation development, biopharmaceutical characterisation, ophthalmic drug delivery]]></keywords_en><summary_hr><![CDATA[Bolest suhog oka (engl. dry eye disease, DED) je multifaktorijalna bolest površine oka karakterizirana gubitkom homeostaze suznog filma. Pogađa milijune ljudi širom svijeta sa značajnim utjecajem na kvalitetu života. Prevalencija raste s dobi, no relativno visoke stope prevalencije zabilježene su i u mlađih ispitanika zbog ogromnog porasta uporabe digitalnih uređaja.U/V nanoemulzije (NE), ultrafine disperzije ulja u vodi, imaju veliki potencijal učinkovitog liječenja DED-a. Tijekom protekla dva desetljeća NE se razvijaju kao strategija za poboljšanje bioraspoloživosti imunomodulatora ciklosporina A (CsA) u oku nakon topikalne primjene. CsA se koristi u liječenju težih oblika DED-a, potrebno ga je koristiti dulje vrijeme, a početak djelovanja mu je odgođen. Kratkotrajna premedikacija topikalnim glukokortikoidima ili nesteroidnim protuupalnim lijekovima (NSAID) može osigurati brže otklanjanje simptoma u odnosu na CsA monoterapiju. Štoviše, topikalni glukokortikoidi ili NSAID imaju potencijal učinkovitog liječenja blagog do umjerenog DED-a. Razvoj formulacije s učinkom na stabilizaciju suznog filma, produljenim zadržavanjem na površini oka i produljenim oslobađanjem djelatne tvari omogućio bi smanjenje potrebne doze, odnosno bolji omjer koristi i rizika oftalmičkog lijeka. BeatDED projektom predviđen je strukturirani pristup razvoju NE s visokim kliničkim potencijalom za učinkovito liječenje DED-a. Strukturirani pristup osigurat će korištenje biorelevantnih in vitro alata razvijenih u sklopu projekta. Posebna pozornost posvetit će se izboru pomoćnih (bioaktivnih pomoćnih tvari fiziološki prisutnih u suznom filmu) i djelatnih tvari (glukokortikoidi i NSAID) s ciljem postizanja optimalne ravnoteže između svojstava formulacije i učinka formulacije na površini oka. Biorelevantni in vitro alati konstruirani na temelju ključnih fizioloških i anatomskih aspekata površine oka omogućit će razumijevanje procesa na međupovršini formulacije i površine oka.]]></summary_hr><summary_en><![CDATA[Dry eye disease (DED), a multifactorial disease of the ocular surface, is characterized by a loss of homeostasis of the tear film. DED affects millions of people worldwide, with a significant impact on the quality of life. The prevalence of DED increases with age. However, relatively high prevalence rates were reported in younger subjects due to enormous use of digital devices.O/w nanoemulsions (NE), ultrafine dispersions of oil in water, hold great potential for effective DED treatment. Over the past two decades, NEs are being developed as a strategy to enhance the eye-related bioavailability of immunomodulator cyclosporine A (CsA) following topical instillation. CsA is used in the treatment of severe DED; it has to be used for extended periods of time and its onset of action is postponed. Topical glucocorticoids or non-steroidal anti-inflammatory drugs (NSAIDs) short-term pretreatment could provide faster symptom relief than topical CsA alone. Moreover, topical glucocorticoids or NSAID have potential for effective treatment of mild-to-moderate DED. Development of formulations with tear film stabilizing effect, prolonged residence at ocular surface and sustained drug release would enable the reduction of required drug dose and consequent better benefit-risk balance of ophthalmic drug product. The BeatDED project envisions a structured approach to efficient development of NE with high clinical potential for the effective DED treatment guided by the developed biorelevant in vitro tools. Particular emphasis will be devoted to the selection of excipients (bioactive excipients normally present in the tear film) and drugs (glucocorticoids and NSAIDs) in order to achieve optimal balance between formulation properties and formulation effect on the ocular surface. The availability of biorelevant in vitro tools constructed on the basis of key physiological and anatomical aspects of ocular surface will enable understanding of processes at formulation/ocular surface interface.]]></summary_en></project><project>
<id>9328</id><title_hr><![CDATA[Optimiranje depozicije raspršenih in situ gelirajućih i praškastih terapijskih sustava u nosnoj šupljini]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5296</user_id><user_firstLast_name>Anita Hafner</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-2473</code><acronim><![CDATA[OptiNasalSpray]]></acronim><duration>26.10.2020 - 26.10.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Farmacija, </scie_field_hr><scie_field_en>Pharmaceutical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Farmaceutsko-biokemijski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Pharmacy and Biochemistry]]></institution_en><team_members_id>858334</team_members_id><team_members_names><![CDATA[ Doktorand: Mirna Perkušić ]]></team_members_names><keywords_hr><![CDATA[Profil depozicije, profil raspršivanja, in situ geliranje, sušenje raspršivanjem, nazalna primjena, flutikazon, donepezil]]></keywords_hr><keywords_en><![CDATA[Deposition pattern, spray pattern, in situ gelling, spray drying, nasal delivery, fluticasone, donepezil]]></keywords_en><summary_hr><![CDATA[Nazalna primjena privlači značajnu pažnju svjetske znanstvene zajednice kao atraktivni put primjene lijekova sa lokalnim i sistemskim učinkom, te naročito neuroloških lijekova koji se mogu dostaviti direktno iz nosne šupljine u mozak. Anatomija i fiziologija nosne šupljine prepoznati su kao kritični faktori u razvoju terapijskih sustava, a posebice mukocilijarni mehanizam čišćenja koji ograničava vrijeme kontakta lijeka s nosnom sluznicom. Međutim, ključni parametar o kojem ovisi terapijski ishod nazalno primijenjenog lijeka je njegova depozicija unutar nosne šupljine.Cilj predloženog projekta je razviti terapijski sustav za nazalnu primjenu u obliku spreja, pažljivo dizajniranog profila depozicije i povoljnih biofarmaceutskih svojstava, a ovisno o ciljnom učinku lijeka. U istraživanju će se koristiti dva modelna lijeka, flutikazon – lijek s lokalnim učinkom koji treba doseći zonu polipa iza nosnih valvula, te donepezil- antidementik kojeg treba dostaviti u olfaktorno područje nosne šupljine kako bi se omogućila njegova direktna dostava u mozak. U izradi terapijskih sustava ispitat će se i usporediti primjenjivost dviju tehnologija s jednostavnim uvećanjem procesa: tehnologija in situ gelirajućih sustava i prašaka pripravljenih sušenjem raspršivanjem. Navedene tehnološke platforme omogućuju razvoj terapijskih sustava koji mogu produljiti vrijeme zadržavanja na mjestu depozicije te kontrolirati profil oslobađanja i apsorpcije lijeka.Nazalna depozicija ispitivat će se primjenom modela nosne šupljine uz simuliranje protoka zraka pri disanju. Fino ugađanje profila depozicije omogućit će se variranjem procesnih i formulacijskih parametara, uz primjenu različitih raspršivača i parametara primjene.Primjena statističkog dizajna eksperimenata omogućit će vrednovanje i razumijevanje utjecaja promatranih parametara na svojstva/profil depozicije in situ gelirajućih i praškastih sustava, te razvoj nazalnih pripravaka s ugrađenom kvalitetom uz uštedu uloženih sredstava i vremena.]]></summary_hr><summary_en><![CDATA[Nasal delivery receives much attention of the worldwide scientific community as an attractive route for drugs with local or systemic effect, and especially neurological drugs that can be delivered directly from the nasal cavity to the brain. The anatomy and physiology of the nasal cavity are recognized as the most critical factors in drug delivery system design, especially mucociliary clearance that limits the contact time between the drug and mucosa. However, the crucial parameter for the treatment outcome of nasally applied drug is its deposition within the nasal cavity. The purpose of the proposed project is to develop sprayable nasal delivery systems with carefully designed deposition pattern and favorable biopharmaceutical properties, in relation to targeted drug effect. Two model drugs will be used: fluticasone - a locally acting drug that needs to reach the polyp zone beyond the nasal valve, and donepezil - antidementic drug that needs to be deposited in the olfactory region within the nasal cavity to be directly transported to the brain.For the formulation development, applicability of two technologies that can be easily scaled up will be assessed and compared, namely, technology of in situ gelling systems and spray-dried powders. These technological platforms can be used to develop formulations able to prolong residence time at the deposition site and control drug release and absorption profiles.Nasal deposition will be studied using nasal cavity model simulating breath airflow. The deposition pattern will be fine-tuned by varying process and formulation parameters, in conjunction with different nasal devices and administration parameters.The usage of statistical Design of Experiments will enable the evaluation and elucidation of the influence of parameters employed on the characteristics/deposition pattern of developed drug delivery systems, potentiating the development of nasal formulations with built-in quality attributes in cost and time-saving manner.]]></summary_en></project><project>
<id>9331</id><title_hr><![CDATA[Od oblika do funkcije: Fleksibilni kristalni materijali s kontroliranim mehaničkim odzivom]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1229</user_id><user_firstLast_name>Marijana Đaković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-9386</code><acronim><![CDATA[FlexibleCrystals]]></acronim><duration>09.11.2020 - 08.11.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>858397</team_members_id><team_members_names><![CDATA[ Doktorand: Ozana Mišura ]]></team_members_names><keywords_hr><![CDATA[kristali s mehaničkim odzivom, elastično savitljivi kristalni materijali, koordinacijski polimeri, kristalno inženjerstvo, nekovalentne interakcije]]></keywords_hr><keywords_en><![CDATA[mechanically responsive crystals, crystalline materials with elastic flexibility, coordination polymers, crystal engineering, non-covalent interaction]]></keywords_en><summary_hr><![CDATA[Mehanička savitljivost, iako osnovno svojstvo većine živih sustava, rijetko se pojavljuje kod kristalnih materijala. Kristalne krutine općenito su nesavitljive i lako pucaju i/ili se lome pri izlaganju mehaničkom podražaju, osobito ako su im građevne jedinke povezane međumolekulskim interakcijama usporedive jakosti u svim smjerovima. Međutim, nekoliko nedavno objavljenih znanstvenih radova opisuje savitljive organske kristale i svega nekoliko primjera 0-D metaloorganskih kristalnih krutina koje mogu pokazivati savitljivost pod utjecajem mehaničke sile. Prvi rad o mehanički savitljivim kristalnim 1-D koordinacijskim polimerima objavljen je 2018. godine. U tom radu smo pokazali da se stupanj elastičnosti može kontrolirati uvođenjem malih ali kontroliranih strukturnih promjena, a takvo nešto dosad još nije bilo poznato.S ciljem potpunog razumijevanja i objašnjenja uvjeta potrebnih za prilagodljivost i ugodivu savitljivost kristalnih koordinacijskih polimera pod utjecajem vanjskog mehaničkog podražaja, predlažemo kombinaciju teorije i eksperimenta za sustavno istraživanje specifičnih strukturnih značajki i međumolekulskih interakcija te njihovog utjecaja na mehanička svojstva kristalnih koordinacijskih polimera. Glavni je cilj ovog interdisciplinarnog istraživanja na granici kemije i znanosti o materijalima definirati postojane i prenosive smjernice za dizajn kristalnih koordinacijskih polimera s a priori određenom savitljivošću, na temelju ‘bottom-up’ pristupa. Takvi materijali imali bi najbolja svojstva meke i kristaline tvari – ugodivu pokretljivost i očuvanu uređenost dalekog dosega. Time bi pružili nove i jedinstvene mogućnosti znanosti o materijalima i inženjerstvu, jer navedeni koordinacijski polimeri omogućuju dosad nezamisliv uvid u novu generaciju pametnih materijala s ugodivom funkcijom.]]></summary_hr><summary_en><![CDATA[Mechanical flexibility, an essential characteristic of most living systems, is rare among crystalline materials. Crystalline solids are in general brittle, and they tend to crack and/or break upon application of mechanical stress, especially if they are held together by intermolecular bonds that are of comparable strength in all directions. Recently, however, there have been several publications describing flexible organic crystals, and a few cases of 0-D metal-organic crystalline solids that can respond flexibly to an applied mechanical force.  The very first paper on crystalline 1-D coordination polymers with mechanical flexibility was published in 2018, wherein we also demonstrated that the extent of elasticity could be controlled by introducing small and controllable structural modifications, something that had not been accomplished before. In order to fully understand and explain which conditions need to be met for crystalline coordination polymers to be adaptive and tunably flexible in response to external mechanical stimuli, we propose a combination of theory and experiment to systematically explore how specific structural features and intermolecular interactions impart mechanical properties in crystalline coordination polymers. The overarching goal of this interdisciplinary research effort at the interface of chemistry and materials science is to deliver robust and transferable guidelines for bottom-up design of coordination polymers with a priori determined flexibility.  Such materials would combine the best features of both soft and crystalline matter, by presenting tunable mobility whilst preserving a long-range order, and subsequently offer unique opportunities for materials science and engineering as they contain coordination polymers at their core, which can provide unprecedented access to a new generation of smart materials with tunable functionality.]]></summary_en></project><project>
<id>9332</id><title_hr><![CDATA[Učinci višestrukih stresora na biološku raznolikost i funkcije slatkovodnih ekosustava]]></title_hr><title_en><![CDATA[]]></title_en><user_id>20412</user_id><user_firstLast_name>Ana Previšić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-6998</code><acronim><![CDATA[MUSE]]></acronim><duration>11.11.2020 - 10.05.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>858400</team_members_id><team_members_names><![CDATA[ Doktorand: Iva Kokotović ]]></team_members_names><keywords_hr><![CDATA[višestruki stresori, slatkovodna bioraznolikost, funkcije ekosustava, DNA barkodiranje, spektrometrija masa]]></keywords_hr><keywords_en><![CDATA[multiple stressors, freshwater biodiversity, ecosystem functioning, DNA barcoding, mass spectrometry]]></keywords_en><summary_hr><![CDATA[Posljednja znanstvena dostignuća prepoznaju sve veći utjecaj višestrukih stresora na vodna tijela u Europi, što rezultira velikim promjenama bioraznolikosti, funkcija i usluga slatkovodnih ekosustava. S druge strane, učinci stresora na bioraznolikost vrsta ostaju uglavnom neotkriveni korištenjem viših taksonomskih kategorija u biomonitoringu. Slično tome, razumijevanje bioakumulacije i biomagnifikacije onečišćivača (npr. farmaceutski aktivnih spojeva, endokrinih disruptora, mikroplastike) u hranidbenim mrežama je nepotpuno. Nadalje, postoji malo podataka o prijenosu onečišćivača iz vodenih u kopnene hranidbene mreže. Sukladno tome, ovaj projekt ima za cilj unaprijediti naše znanje o učincima višestrukih stresora na: I) bioraznolikost slatkovodnih ekosustava, te na II) funkcije slatkovodnih ekosustava i povezanost vodenih i kopnenih staništa. Kako bi se ostvarili navedeni ciljevi, provesti će se terenska istraživanja i laboratorijski pokusi. Predloženo istraživanje unaprijediti će razumijevanje odgovora pojedinih vrsta i populacija na stresore u okolišu primjenom suvremenih alata, tj. DNA barkodiranja. Posljednja dostignuća spektrometrije masa koristiti će se za proučavanje profila metabolita te identifikaciju i kvantifikaciju onečišćivača u tkivima organizama. Očekivani rezultati dati će važan doprinos poznavanju uloge različitih predstavnika pojedinih trofičkih nivoa u putovima prijenosa onečišćivača kroz hranidbene mreže i ekosustave. Uspostavom suradnje sa svjetski poznatim znanstvenikom iz vodećeg europskog istraživačkog instituta i tri dodatne europske znanstvene institucije, mobilizirat će se jedinstvena kombinacija vještina i multidisciplinarnog znanja za provedbu projektnih aktivnosti. Sukladno tome, osim jačanja kapaciteta hrvatskih znanstvenika i institucija, očekujemo da će rezultati ovog istraživačkog plana imati značajan utjecaj na istraživanje slatkih voda.]]></summary_hr><summary_en><![CDATA[Current state-of-the-art research identifies Europe’s water bodies influenced by a complex mixture of stressors. As a result, biodiversity, ecosystem functions and services of the freshwaters are changing at an unprecedented rate. Impacts of stressors on species remain undetected when taxa are merged to a higher taxonomic level for biomonitoring. Similarly, understanding of bioaccumulation and biomagnification of emerging contaminants (ECs, e.g. pharmaceuticals, endocrine disrupting compounds, microplastics) in aquatic food webs are incomplete. Furthermore, there are only few studies on transfer of ECs to terrestrial ecosystems through the vital aquatic-terrestrial habitat linkage (ATHL). Accordingly, this project aims at advancing our knowledge on effects of multiple stressors on: I) freshwater biodiversity and II) ecosystem functioning and ATHL. Objectives will be approached by combining field-based research and laboratory mesocosm experiments. The proposal aims on providing novel insights into species- and lineage-specific responses to environmental stressors through application of the DNA barcoding method. Furthermore, the last generation analytical methods, such as hybrid and high resolution mass spectrometry, will be used to study metabolomic profiles and to detect ECs in biota samples. Anticipated results will provide essential links necessary for evaluation of routes and mechanisms of ECs transfer through food webs and ecosystems and for development of more realistic biomagnification scenarios. By establishing collaboration with world known scientist from a leading European water research institute and 3 additional European scientific institutions, unique combination of skills, expertise and knowledge will be mobilised to carry out the project activities. Accordingly, besides capacity building of Croatian scientists and institutions, the results produced by this innovative research plan will have substantial impact on the field of inland water research.]]></summary_en></project><project>
<id>9334</id><title_hr><![CDATA[Simetrije u kvantnoj gravitaciji]]></title_hr><title_en><![CDATA[]]></title_en><user_id>52</user_id><user_firstLast_name>Larisa Jonke</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-1909</code><acronim><![CDATA[SYMM4QG]]></acronim><duration>11.01.2021 - 10.07.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>862763</team_members_id><team_members_names><![CDATA[ Doktorand: Toni Kodžoman ]]></team_members_names><keywords_hr><![CDATA[dvostruka teorija polja, viša baždarna teorija, više grupe, Drinfeldov twist, L_infinity algebra]]></keywords_hr><keywords_en><![CDATA[double field theory, higher gauge theory, higher group, Drinfel&#39;d twist, L_infinity algebra]]></keywords_en><summary_hr><![CDATA[Važnost simetrija u istraživanjima u fizici ne može se prenaglasiti. Posebice, izniman uspjeh opće relativnosti u opisivanju prirode gravitacijske interakcije, što je potvrđeno u brojnim eksperimentima, temelji se na detaljnom razumijevanju fundamentalnih simetrija. Međutim, postoje jaki teorijski dokazi da je za opisivanje fizikalnih fenomena u kvantnoj gravitaciji nužno poopćiti dosad korištene principe simetrija. Predloženo istraživanje ima za cilj unaprijediti razumijevanje generaliziranih principa simetrije relevantnih za teoriju kvantne gravitacije kao jednog od temeljnih elemenata još nepoznate  teorije. Koristeći skup modela motiviranih teorijom struna kao približenje za kvantnu gravitaciju istražit ćemo relevantne strukture simetrije i njihove fizikalne implikacije. Očekujemo da će naši rezultati pridonijeti i formalnom matematičkom razumijevanju generaliziranih simetrija i razvoju konkretnog fizikalnog opisa fenomena kvantne gravitacije.]]></summary_hr><summary_en><![CDATA[The importance of symmetries in physics research cannot be overemphasized. In particular, the exceptional success of general relativity in describing the nature of gravitational interaction, as confirmed in numerous experiments, is based on thorough understanding of the underlying symmetries. However, there exists strong theoretical evidence that in order to describe physical phenomena in the quantum gravity regime one has to allow for more general symmetry structures. The proposed research aims at advancing our understanding of generalized symmetry principles relevant for a theory of quantum gravity as one of the building blocks of so far elusive theory. Using a set of models motivated by string theory as proxies for quantum gravity we shall investigate relevant symmetry structures and their physical implications. We expect that our result will contribute both to the more formal, mathematical understanding of generalized symmetries and to the development of concrete physical description of quantum gravity related phenomena.]]></summary_en></project><project>
<id>9336</id><title_hr><![CDATA[Otpad i Sunce u službi fotokatalitičke razgradnje Mikroonečišćivala u vodama (OS-Mi)]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5338</user_id><user_firstLast_name>Domagoj Vrsaljko</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-8955</code><acronim><![CDATA[]]></acronim><duration>10.09.2020 - 09.12.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Kemijsko inženjerstvo, </scie_field_hr><scie_field_en>Chemical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet kemijskog inženjerstva i tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Chemical Engineering and Technology]]></institution_en><team_members_id>856063</team_members_id><team_members_names><![CDATA[ Doktorand: Ivan Karlo Cingesar ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>9340</id><title_hr><![CDATA[Dizajn naprednih biokompozita iz energetski održivih izvora ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5608</user_id><user_firstLast_name>Nikola Bilandžija</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-3206</code><acronim><![CDATA[]]></acronim><duration>26.10.2020 - 14.01.2027</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Agronomski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Agriculture]]></institution_en><team_members_id>858337</team_members_id><team_members_names><![CDATA[ Doktorand: Anamarija Gudelj Velaga ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>9341</id><title_hr><![CDATA[Topološka raznolikost oksalatnih spojeva: sinteza, svojstva i upotreba za okside]]></title_hr><title_en><![CDATA[]]></title_en><user_id>12831</user_id><user_firstLast_name>Marijana Jurić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-4677</code><acronim><![CDATA[TOPOXAL-SYPROXID]]></acronim><duration>01.11.2020 - 30.04.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>858406</team_members_id><team_members_names><![CDATA[ Doktorand: Ana Lozančić ]]></team_members_names><keywords_hr><![CDATA[Homo- i heterometalni koordinacijski spojevi, oksalatni most, strukturna analiza, mješoviti metalni oksidi, magnetska i električna svojstva]]></keywords_hr><keywords_en><![CDATA[Homo- and heterometallic coordination compounds, oxalate bridge, structural analysis, mixed-metal oxides, magnetic and electrical properties]]></keywords_en><summary_hr><![CDATA[Metal-organski koordinacijski spojevi zbog prilagodljive prirode organskih liganda i njihovog različitog načina koordiniranja, kao i geometrije metalnih iona koji ih izgrađuju, mogu imati različite topologije i arhitekture. Osim strukturnog svojstva, ove kristalne krutine mogu pokazivati i druga zanimljiva svojstva koja proizlaze iz različitih funkcionalnosti koja se uvode u ove materijale, naročito elektronska svojstva tj. magnetska, električna ili optička, prihvatljivim odabirom metalnih iona, organskih spojnica i načina na koji su oni međusobno povezani u krutini, ili uvođenjem funkcionalnih molekula u pore. U potrazi za novim molekulskim magnetima intenzivno se proučavaju kompleksi koji sadrže oksalatnu skupinu, C2O42–, koja ima mogućnosti raznolikog vezivanja na metalne ione i posredovanja u magnetskoj interakciji između paramagnetskih centara. Također, zbog razlaganja ovog liganda na plinovite faze, CO2 i CO, pri niskim temperaturama, kao i njegove niske cijene, heterometalni oksalatni sustavi se koriste kao molekulski prekursori za pripravu mješovitih metalnih oksida termičkom pretvorbom. Sveukupni znanstveni cilj predloženog projekta, koji se temelji na interdisciplinarnom pristupu, je istražiti nove homo- i heterometalne komplekse s premošćujućom oksalatnom skupinom, te okside priređene iz odgovarajućih oksalatnih spojeva. Pripremljenim oksalatnim spojevima i) homopolinuklearnim s jednostavnim aminima i ii) heteropolinuklearnim, sintetiziranim pristupom građevnih blokova, koji sadrže aromatske N-donorske ligande ili jednostavne amine, istražit će se strukturna, termička, magnetska i električna svojstva. Za svaki jednofazni produkt dobiven termičkom razgradnjom i) novopripravljenih heterometalnih oksalatnih spojeva, ii) smjese pogodnih, već poznatih hetero- i/ili homometalnih oksalatnih spojeva, te iii) čvrstih otopina dvaju prikladnih oksida, odredit će se energetski procijepi i fotokatalitička aktivnost, te istražiti magnetska i električna svojstva.]]></summary_hr><summary_en><![CDATA[The flexible nature of organic ligands and their variety of coordination modes, together with the geometry of the constitutive metal ions, provide a diversity of topologies and architectures of metal-organic coordination compounds. In addition to the structural property these crystalline solids may exhibit other interesting properties resulting from different functionalities introduced into these materials, in particular, electronic properties, i.e. magnetic, electrical or optical, by acceptable selection of the functional nodes, organic linkers and the way in which they are connected in the solid, or by including functional molecules in the pores. In the search for new molecule magnets, oxalate-based complexes have been intensively studied; the oxalate moiety, C2O42–, has rich binding facilities and can act as efficient mediators of the magnetic interaction between paramagnetic centres. Also, due to its easily decomposes to gaseous CO2 and CO at low temperatures and cheapness, heterometallic oxalate compounds have been used as molecular precursors for the preparation of mixed-metal oxides by thermal conversion. The overall scientific aim of this project, based on interdisciplinary approach, is to explore novel homo- and heterometallic oxalate-bridged complexes and the oxides derived from suitable oxalate species. Prepared oxalate compounds i) homopolynuclear with simple amine and ii) heteropolynuclear, synthesized by a building block approach, containing organic N-donor ligand or simple amine, will be structural, thermal, magnetic and electrical characterized. For every single-phase product obtained by thermal decomposition of i) newly synthesized heterometallic oxalate compounds, ii) the mixture of agreeable, well-known hetero- and/or homometallic oxalate compounds or iii) solid state solutions of two appropriate mixed-metal oxides, the band gaps and photocatalytic activity will be determined, as also characterization from magnetic and electrical points of view. ]]></summary_en></project><project>
<id>9342</id><title_hr><![CDATA[Metode za interpretaciju medicinskih snimki za detaljnu analizu zdravlja srca]]></title_hr><title_en><![CDATA[]]></title_en><user_id>21436</user_id><user_firstLast_name>Irena Galić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-3976</code><acronim><![CDATA[IMAGINEHEART]]></acronim><duration>07.10.2020 - 06.10.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera Osijek, Fakultet elektrotehnike, računarstva i informacijskih tehnologija Osijek]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Electrical Engineering, Computer Science and Information Technology Osijek]]></institution_en><team_members_id>856226</team_members_id><team_members_names><![CDATA[ Doktorand: Marin Benčević ]]></team_members_names><keywords_hr><![CDATA[srce, segmentacija, analiza slike, simulacija, vizualizacija, programska biblioteka otvorenog koda, višestruka analiza zdravlja]]></keywords_hr><keywords_en><![CDATA[heart, segmentation, image analysis, simulation, visualisation, open source library, multiple health analysis]]></keywords_en><summary_hr><![CDATA[Kardiovaskularne bolesti uzrokuju godišnje više od 40% svih smrti u Europskoj Uniji. Metode snimanja u medicinske svrhe nezaobilazne su za utvrđivanje stanja kardiovaskularnog zdravlja neke osobe, a najčešće metode su računalna tomografija (CT) i magnetska rezonanca (MRI). Interpretacija tako prikupljenih medicinskih slika izrazito je ovisna o metodama računalne obrade, a potrebna programska podrška često je vrlo skupa i vezana uz proizvođača pojedinog uređaja, što otežava pristup takvom softveru manjim bolnicama i istraživačima.Osnovni cilj ovog projekta je razviti nove metode za analizu kardiovaskularne slike koje će moći odrediti što je više moguće kardiovaskularnih kvantifikacija srca iz što je moguće manje slika kako bi se postigla višestruka analiza kardiovaskularnog zdravlja. Takva analiza postići će se utvrđivanjem uzročno posljedičnih veza između određenih kvantifikacija i njihove dokazane utjecaje na kardiovaskularno zdravlje. Primjer kvantifikacija koje se mogu koristiti su: geometrija i volumen srca, geometrija bitnih arterija, morfologija aurikula lijeve pretklijetke, tok krvi kroz aortu, analiza srčane popustljivosti te kvantizacija epikardijalne masti. Odstupanje od normalnih vrijednosti gotovo svake od ovih kvanfitikacija faktor je rizika u razvoju neke od srčanih bolesti. Prepoznavanjem takvih odstupanja na vrijeme omogućit će se prepoznavanje potencijalnih rizika za zdravlje pacijenta što predstavlja fundamentalno poboljšanje u dijagnostici i tretmanu pacijenata.Konačan rezultat projekta bit će programska biblioteka otvorenog koda za analizu kardiovaskularnih slika, koja će sadržavate metode za sve kvantifikacije razvijene tijekom projekta. Bit će objavljena pod BSD licencom što će omogućiti suradnju i s industrijom i s akademskom zajednicom te će omogućiti istraživačima jednostavniju validaciju rezultata jer trenutno većina postojećih metoda nije javno dostupna istraživačima.]]></summary_hr><summary_en><![CDATA[Cardiovascular diseases are the main causes of more than 40% of all deaths in the European Union. Medical imaging techniques are unavoidable tools in the assesment of patient&#39;s cardiovascular health with the most often used methods being Computed Tomography (CT) and Magnetic Resonance Imaging (MRI).Interpretation of medical images acquired using these techniques depends on available image processing methods. Software packages implementing such methods are often both very expensive and proprietary, which means that small hospitals and research groups have difficulties purchasing such software.The main goal of this project is to develop a new method for the analysis of cardiovascular images which will be able to determine as many cardiovascular quantifications as possible using the lowest possible number of images, which will enable multiple analysis of cardiovascular health. Such analysis will determine the relationship between different hearh quantifications and risk factors for the development of cardiovascular diseases. The examples of quantifications that will be used are heart geometry and volume, geometry of important arteries, LAA morphology, blood flow through aorta, heart compliance, epicardial fat, etc. A discrepancy from reference values of each of these quantifications is a risk factor in the development of some heart disease.The final result of the project will be an open source library for cardiovascular image processing containing implementations of all methods developed within the scope of the project. The developed open source library will be BSD licensed fostering future cooperation with both academia and industry.]]></summary_en></project><project>
<id>9344</id><title_hr><![CDATA[Rogozničko morsko jezero kao model odziva ekosustava na promjene u okolišu]]></title_hr><title_en><![CDATA[]]></title_en><user_id>287</user_id><user_firstLast_name>Irena  Ciglenečki-Jušić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-3195</code><acronim><![CDATA[MARRES]]></acronim><duration>01.10.2020 - 30.09.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Interdisciplinarne prirodne znanosti, </scie_field_hr><scie_field_en>Interdisciplinary natural sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>856281</team_members_id><team_members_names><![CDATA[ Doktorand: Niki Simonović ]]></team_members_names><keywords_hr><![CDATA[Rogozničko jezero,  specijacija i dinamika S spojeva,biogeokemijski procesi, unos iz atmosfere,  radionuklidi ]]></keywords_hr><keywords_en><![CDATA[Rogoznica lake, S speciation and dynamics, biogeochemical processes, atmospheric input, radionuclides]]></keywords_en><summary_hr><![CDATA[MARRES, nastavak SPHERE projekta, ima za cilj koristiti jedinstveni okoliš Rogozničkog jezera kao primjer  ugroženog morskog sustava koji odražava sve hidrografske i atmosferske uvjete Jadranskog mora. U okviru MARRES-a  Rogozničko jezero biti će model za praćenje i karakterizaciju biogeokemijskih procesa kruženja sumpora i ugljika na različitim redoks granicama faza, odnosno pri različitim okolišnim uvjetima. Znanstvenu misiju MARRES će postići suvremenim laboratorijskim tehnikama i radom na terenu, objedinjenim u jedinstveno biogeokemijsko istraživanje. Važan dio projekta biti će usmjeren na transport i izmjenu između atmosfere, vodenog stupca i sedimenta jezera, mjerenjem unosa sumpornih spojeva, organske tvari, radionuklida, nutrijenata i tragova metala mokrim taloženjem iz kiše. Ovisno o specifičnim fizičko-kemijskim uvjetima  pratiti će se i diskutirati ekologija mikroorganizama, fito- i zoo-planktona, te bentosa. Analiza i rasprava novih i dugoročnih podataka ekološkog  statusa jezera, osnovni je preduvjet za razvoj biogeokemijskog modela. Osim Rogozničkog jezera, drugi sustav za praćenje promjena u okolišu povezanih s eutrofikacijom, biti će sjeverni Jadran kao primjer poluzatvorenog, plitkog i potencijalno eutrofnog morskog bazena s povremenim pojavama pridnene anoksije. Istraživanja MARRESa planirana su na vremenskoj skali  od 4 godine, a dobiveni rezultati će značajno pridonijeti općem znanju o stanju i odgovorima istraživanih ekosustava na promjene fizikalnih, kemijskih i bioloških uvjeta uslijed prirodnih i antropogenih, odnosno globalnih promjena u okolišu. Gore navedeni istraživački ciljevi, posebice oni vezani za mobilizaciju ljudskih, tehničkih i infrastrukturnih kapaciteta IRB-a, kao i uključenih partnerskih institucija, usko su usklađeni sa strateškim prioritetima i promicanjem hrvatske znanosti, znanja i iskustva na svjetskom znanstvenom tržištu.]]></summary_hr><summary_en><![CDATA[MARRES, the continuation of the SPHERE project, aims to put in focus Rogoznica lake as an unique example of the threatened marine ecosystems, which feels hydrographic and atmospheric conditions of the Adriatic Sea. Rogoznica lake will be a model for monitoring and characterization of biogeochemical processes related to sulfur and carbon cycling at different redox boundaries under different environmental conditions. The project will achieve scientific mission by state-of-the art laboratory studies and field monitoring integrated in an unique biogeochemical research. Discussion and synthesis of new and long term data of the Lake’s ecological status is fundamental for development of biogeochemical model. An important part of the project will be focused on the exchange and transport between atmosphere, water column and sediment by measuring the atmospheric input (wet deposition) of sulfur compounds (organic and inorganic), organic carbon, radionuclides (Be-7, Pb-210), nutrients and trace metals. Additionally, the ecology of the microorganisms, phyto-  and zoo-plankton, bentos will be correlated with specific lake water physico-chemical conditions. The northern Adriatic as a semi closed, shallow and potentially eutrophic marine basin with occasional appearance of bottom anoxia will be used as another system for tracking environmental changes related to eutrophication. The MARRES is planned for the period of 4 years, and its result will contribute substantially to the improvement of the knowledge on the studied ecosystems responses to likely changes of physical, chemical and biological conditions affected by natural and anthropogenic i.e. global environmental change. Research objectives listed above, especially those related to mobilization of human, technical, and infrastructural capacities of the RBI and involved partner Institutions  are closely in line with strategic priorities and promotion of Croatian science, knowledge and experience on the world science market.]]></summary_en></project><project>
<id>9347</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1207</user_id><user_firstLast_name>Helena Bilandžija</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-4618</code><acronim><![CDATA[Evodark]]></acronim><duration>01.11.2020 - 31.05.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>858357</team_members_id><team_members_names><![CDATA[ Doktorand: Magdalena Grgić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[cave dwelling animals, the loss of pigmentation, adaptation to darkness, the evolution of novel phenotypes, convergent evolution]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[How organisms adapt to the environment and generate novel phenotypes are fundamental questions in biology. Cave adapted animals offer outstanding opportunities to answer them because the cave environment is simple, novel phenotypes evolved convergently in different phyla, and surface dwelling relatives resembling the ancestral form are available for comparative studies. I will integrate molecular, cellular, and organismal approaches to 1) explore the effect of the environment and 2) investigate the molecular origin of a major evolutionary adaptation. 1. By exposing closely related surface relatives to constant darkness in controlled laboratory conditions we can identify the adaptations in the cave forms that evolved due to the lack of light - the major feature of caves. My previous research on the fish Astyanax mexicanus showed that traits considered as cave adaptations (e.g. metabolism, stress response) can be induced by exposing the surface form to darkness.  I propose to investigate i) the molecular mechanisms that underlie these phenotypic changes in Astyanax surface fish and ii) whether darkness would induce similar changes in closely related surface relatives of cave adapted invertebrates (arthropods, planaria). 2. One of the hallmarks of cave adaptations is the loss of pigmentation, present almost ubiquitously in all groups regardless of the type of pigment they synthesize. My previous research identified a relevant molecular change in multiple cave animals with melanin pigmentation, and that natural selection as opposed to drift is likely involved. Nothing is known about the other pigments that are lost in cave animals.  Therefore, I propose to investigate the molecular and evolutionary mechanisms of ommochrome and porphyrin loss in cave adapted arthropods and planaria. Insights from these studies would provide new understanding of the mechanisms of convergent evolution and the genetic origin of novel phenotypes.]]></summary_en></project><project>
<id>9348</id><title_hr><![CDATA[Mehanizmi nastajanja snopova mikrotubula potrebni za sazrijevanje diobenog vretena]]></title_hr><title_en><![CDATA[]]></title_en><user_id>11207</user_id><user_firstLast_name>Iva Tolić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-7925</code><acronim><![CDATA[SpindleForm]]></acronim><duration>20.10.2020 - 19.10.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>861477</team_members_id><team_members_names><![CDATA[ Doktorand: Mateja Ćosić ]]></team_members_names><keywords_hr><![CDATA[diobeno vreteno, mikrotubuli, proteini koji povezuju mikrotubule, motorni proteini, kinetohore]]></keywords_hr><keywords_en><![CDATA[mitotic spindle, microtubules, crosslinking proteins, motor proteins, kinetochores]]></keywords_en><summary_hr><![CDATA[Tijekom mitoze stanica formira diobeno vreteno koje simetrično razdvaja kromosome u dvije stanice kćeri. Diobeno vreteno sastoji se od nekoliko klasa mikrotubula, uključujući kinetohorna vlakna koja se vežu na kromosome putem kinetohora i preklapajuće ili interpolarne snopove antiparalelnih mikrotubula koji rastu iz suprotnih polova vretena. Za funkciju vretena potrebna je precizna prostorna organizacija snopova mikrotubula i kinetohora, koja je dobro opisana za metafazno vreteno. Međutim, tijekom prometafaze mikrotubuli su neravnomjerno raspoređeni na području budućeg metafaznog vretena, dok kinetohorna vlakna i preklapajući snopovi još nisu vidljivi. Središnje je pitanje kako se tijekom prometafaze neravnomjerno raspoređeni mikrotubuli preraspoređuju u dobro odijeljene i pravilno organizirane snopove koji smještaju kinetohore u metafaznu ploču. Naši početni pokusi pokazuju da se broj preklapajućih snopova povećava tijekom prometafaze i da novi snopovi mogu nastati uzdužnim cijepanjem postojećih. Da bismo analizirali molekularne mehanizme nastanka snopova, razvit ćemo pristup temeljen na novim humanim staničnim linijama dobivenima CRISPR metodom, koje ćemo proučavati pomoću konfokalne i superrezolucijske mikroskopije. Da bismo identificirali ključne proteine u formiranju snopova, modificirat ćemo ekspresiju proteina kandidata: kinetohornih proteina, motornih proteina i nemotornih proteina koji povezuju mikrotubule. Razvit ćemo i optogenetički pristup za uklanjanje proteina iz vretena, kao i pristup temeljen na bioaktivnim peptidima koji mijenjaju brzinu motornih proteina. Također ćemo identificirati mjesta nastanka kinetohornih vlakana i preklapajućih snopova te njihove detirozinacije, kao i vrijeme njihova formiranja i interakcije. Ovaj će projekt otkriti kako nastaju snopovi mikrotubula koji čine složenu arhitekturu zrelog metafaznog vretena.]]></summary_hr><summary_en><![CDATA[During mitosis, the cell forms a spindle that segregates chromosomes symmetrically into two daughter cells. The mitotic spindle consists of several classes of microtubules, including kinetochore fibers that interact with chromosomes via kinetochores, and overlap or interpolar bundles that consist of antiparallel microtubules extending from the opposite spindle poles. A precise spatial organization of microtubule bundles and kinetochores is necessary for spindle function, and it has been to a large extent described for a metaphase spindle. However, during prometaphase, microtubules are unevenly distributed over the area of the future metaphase spindle, whereas kinetochore fibers and the associated overlap bundles are not yet evident. A central question is how during prometaphase these unevenly distributed microtubules become rearranged into discrete well-organized bundles, which position kinetochores into the metaphase plate. Interestingly, our pilot experiments show that the number of overlap bundles increases during prometaphase, and that new bundles can form by lateral splitting of the existing ones. To dissect the molecular mechanisms of bundle formation, we will develop an approach based on new CRISPR-edited human cell lines, which will be studied by live-cell confocal and superresolution microscopy. To identify key molecular players in bundle formation, we will modify the expression of candidate kinetochore proteins, motor proteins, and non-motor microtubule crosslinkers. Moreover, we will develop an optogenetic approach to remove a crosslinker protein from the spindle, and an approach based on bioactive peptides to modulate motor velocity. Finally, we will identify the sites of kinetochore fiber and overlap bundle formation and detyrosination, as well as the time of their formation and interaction. This project will reveal how microtubule bundles form, giving rise to the highly organized architecture of the mature metaphase spindle.]]></summary_en></project><project>
<id>9350</id><title_hr><![CDATA[Modeliranje šumskih zaliha i tokova ugljika te rizika prema budućim klimatskim scenarijima]]></title_hr><title_en><![CDATA[]]></title_en><user_id>819</user_id><user_firstLast_name>Maša Zorana Ostrogović Sever</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-1407</code><acronim><![CDATA[MODFLUX]]></acronim><duration>01.09.2020 - 30.11.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Šumarstvo, </scie_field_hr><scie_field_en>Forestry, </scie_field_en><institution_hr><![CDATA[Hrvatski šumarski institut]]></institution_hr><institution_en><![CDATA[Croatian Forest Research Institute]]></institution_en><team_members_id>855914</team_members_id><team_members_names><![CDATA[ Doktorand: DOROTEJA DIMOSKI ]]></team_members_names><keywords_hr><![CDATA[procesni modeli, vrtložna kovarijanca, CO2 tokovi, kalibracija modela, klimatske promjene, rizik šumskih požara, izvrtci, sitni korijen, C u tlu, C:N]]></keywords_hr><keywords_en><![CDATA[process-based model, eddy covariance, CO2 fluxes, model calibration, climate change, forest fire risk, tree cores, soil carbon, fine roots, C:N ratio]]></keywords_en><summary_hr><![CDATA[Klimatske promjene će utjecati na šume, ali alati, koji bi olakšali procjenu rizika i informirano donošenje odluka temeljeno na razumijevanja biogeokemijskih procesa u šumama, trenutno u Hrvatskoj ne postoje.Cilj MODFLUX-a je osigurati okvir za modeliranje klimatskih promjena koji je prilagođen nacionalnim šumskim ekosustavima i okolišnim uvjetima. Pomoću tehnike model-data-fusion (MDF), kroz iterativni i interaktivni proces usporedbe rezultata modela i izmjerenih podataka, kontinuiranog prilagođavanja parametara modela i moguće modifikacije modela, kalibrirat će se i validirati biogeokemijski procesni model Biome-BGCMuSo za glavne nacionalne šumske ekosustave. U MDF-u će se koristiti dva postojeća neovisna skupa podataka koji će se proširiti podacima iz novih mjerenja. Preciznije, visokofrekventne podaci o tokovima CO2 (EC) sa šumske eksperimentalne stanici u Jastrebarskim lugovima koja je u pogonu od 2008. godine, te baza podataka o sastojinskim značajkama (širina goda, stelja, tlo, sitni korijen) prikupljenih na 250 ploha raspoređenih u kontinentalnoj, alpskoj i mediteranskoj biogeografskoj regiji Hrvatske.Kalibrirani model će poboljšati mogućnosti procjene utjecaja klimatskih promjena na različite tipove šuma u Hrvatskog. Procijenjene promjene u zalihama ugljika u tlu, dobivene kroz MODFLUX, biti će na raspolaganju u izvješćivanju o emisijama stakleničkih plinova u Hrvatskoj. Procjenom rizika šumskih požara u budućim klimatskim scenarijima, MODFLUX će prvi omogućiti donositeljima odluka i široj javnosti uvid u očekivani budući rizika od požara u šumama bogatim dijelovima Hrvatske koji trenutno nisu pogođeni šumskim požarima. Unaprjeđenje postojeće EC stanice osigurat će nastavak međunarodno jedinstvenog istraživanja tokova CO2 u poplavnim šumama hrasta lužnjaka. Rezultati projekta biti će objavljeni u časopisima visokog odjeka, a podaci prikupljeni u okviru projekta bit će učitani u otvorene znanstvene baze podataka.]]></summary_hr><summary_en><![CDATA[Climate change will affect forest but tools, which would facilitate risk assessment and informed decision-making based on understanding undelaying biogeochemical processes in forests, currently do not exist in Croatia. MODFLUX aims at providing a climate change equipped modelling framework that is adapted for national forest ecosystems and environmental conditions. Using a model-data-fusion (MDF) technique, through an iterative and interactive process of comparison of model results and measured data, continuous adjustment of model parameters, and possible modification of the model, we will calibrate and validate a process-based biogeochemical model Biome-BGCMuSo for main national forest ecosystems. In MDF we will use two existing independent datasets which will be expanded with data from new measurements. Namely, a high-frequency eddy covariance (EC) data of CO2 fluxes at forest experimental station in Jastrebarsko operational since 2008, and database of forest strand traits (tree-ring widths, litter, soil, fine roots) collected at 250 plots distributed throughout Continental, Alpine and Mediterranean regions of Croatia. Calibrated model will yield in the improved capacity for the assessment of climate change impact on different forest types. Estimated changes in soil carbon stocks, obtained within MODFLUX, would be available for consideration in Croatia’s GHG reporting. By estimating forest fire risks under future climate scenarios, MODFLUX will be the first to provide to the policymakers, and to the general public, a notion of the expected future fire risks in forest-rich parts of Croatia which are currently not affected by forest fires. Overhaul of the existing EC station will ensure the continuation of the internationally unique research of CO2 fluxes in periodically flooded, pedunculate oak forest. The results will be published in high impact factor journals and data collected within the project will be uploaded to open-accesses scientific databases.]]></summary_en></project><project>
<id>9351</id><title_hr><![CDATA[Vulkano-sedimentne sukcesije sjeverozapadne Hrvatske i njihova uloga u razumijevanju geodinamike Paleotetisa tijekom srednjeg trijasa]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3342</user_id><user_firstLast_name>Damir  Slovenec</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-9520</code><acronim><![CDATA[GOST]]></acronim><duration>17.08.2020 - 19.01.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Geologija, </scie_field_hr><scie_field_en>Geology, </scie_field_en><institution_hr><![CDATA[Hrvatski geološki institut]]></institution_hr><institution_en><![CDATA[Croatian Geological Survey]]></institution_en><team_members_id>855886</team_members_id><team_members_names><![CDATA[ Doktorand: Matija Vukovski ]]></team_members_names><keywords_hr><![CDATA[srednji trijas, vulkano-sedimentne sukcesije, Paleotetis, mineraloško-petrološko-geokemijska karakerizacija, sedimentološka i paleontološka interpreta]]></keywords_hr><keywords_en><![CDATA[Middle Triassic, volcano-sedimentary successions, Paleotethys, mineralogical-petrological-geochemical characterization, sedimentological and palaeonto]]></keywords_en><summary_hr><![CDATA[Budući da se u zapadnom dijelu Paleotetisa vezanom za Alpsko-Karpatsko-Dinaridsko područje tijekom srednjeg trijasa duž kontinentalnih rubova karbonatne platforme odvijala intenzivna magmatska aktivnost, istraživanje vulkano-sedimentnih sukcesija od iznimnog je značaja za rješavanje geodinamike zbivanja. Područje istraživanja ovog projekta uključuje niz gora SZ Hrvatske (Ivanščica, Strahinjščica, Kuna gora, Desinić gora, Ravna gora, Žumberačka gora). Težište istraživanja bit će usmjereno na efuzive i vulkanoklastite interstratificirane u srednjotrijaskim marinskim sedimentnim stijenama. Cilj nam je sustavno proučiti vulkansko-sedimentne asocijacije iz perspektive različitih geoloških disciplina slijedeći suvremeni pristup kroz koji ćemo integrirati mineraloške, petrološke, geokemijske, paleontološke, sedimentološke, izotopne i strukturne podatke kako bi smo razjasnili tektonsku povijest područja. Rezultati će biti dobiveni upotrebom različitih analitičkih metoda i tehnika, uključujući i određivanje izotopne starosti. Analizom i sintezom rezultata  razjasnit će se geneza, karakter, podrijetlo i vrijeme kristalizacije primarnih magmi, zatim rekonstruirati geotektonski okoliši nastanka vulkanskih/vulkanoklastičnih stijena, te pružiti uvid u fizikalno-kemijske uvjete u kojima se zbivalo postkonsolidacijsko trošenje i dijagenetski procesi. Sedimentološkim analizama definirat će se okoliši i uvjeti taloženja vulkano-sedimentnih naslaga, a biostratigrafskim podacima i izotopnim datiranjem nastojat će se odrediti stratigrafski raspon vulkanske aktivnosti. Rezultati će omogućiti nove spoznaje o pojavnosti, načinu, uvjetima i vremenu postanka istraživanih vulkano-sedimentnih sukcesija sjeverozapadne Hrvatske. Takav pristup će u konačnici dovesti do kronološke rekonstrukcije tektonomagmatske evolucije tijekom donjeg mezozoika, što će poslužiti kao okvir za novi jednoznačni petrogenetsko-sedimentološki model razvoja geoloških zbivanja tijekom razdoblja srednjeg trijasa. ]]></summary_hr><summary_en><![CDATA[During middle Triassic, the area of western Paleotethys, specifically the Alpine-Dinaride-Carpathian System, experienced intensive magmatic activity along the carbonate platform margins. Accordingly, understanding the volcano-sedimentary successions is key knowledge to unveil the geodynamics. This project will, therefore, focus on area encompasses the mountain range of NW Croatia (Ivanščica Mt., Strahinjščica Mt., Kuna gora Mt., Desinić gora Mt., Ravna gora Mt., Žumberačka gora Mt.). The focus of this proposal is volcanic/volcaniclastic rocks interstratified within middle Triassic marine sedimentary sequences. We aim to study the volcano-sedimentary associations from the perspective of various geological sub-disciplines following a modern approach where we will integrate mineralogical, petrological, geochemical, paleontological, sedimentological, isotopic and structural data to illuminate the tectonic history of the area. Data will be acquired using multiple analytical methods and techniques  along with the radiometric dating. Processing and synthesis of results will shed light on genesis, characterization and crystallization time of primary magmas. It will furthermore enable reconstruction of the geotectonic setting of the formation of the volcanic rocks and will provide insights into physico-chemical conditions of post-consolidation weathering and diagenetic processes. Sedimentological analyses will be performed in order to define depositional environments of volcano-sedimentary deposits, whereas biostratigraphic and isotopic data will constrain stratigraphic span of volcanic activity. Results will enable new inferences on the occurrences as well as modes, conditions, and time of formation of volcano-sedimentary successions. Such approach will eventually lead to chronological reconstruction of tectono-magmatic evolution during the inception of Mesozoic, which will serve as the framework for a new petrogenetic and sedimentological model for the middle Triassic. ]]></summary_en></project><project>
<id>9352</id><title_hr><![CDATA[Aerodynamic response of cylinder with surface irregularities in critical and transition Reynolds number regimes]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4960</user_id><user_firstLast_name>Hrvoje Kozmar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-5006</code><acronim><![CDATA[]]></acronim><duration>15.01.2021 - 14.01.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, </scie_field_hr><scie_field_en>Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>862796</team_members_id><team_members_names><![CDATA[ Doktorand: Petar Golem ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>9353</id><title_hr><![CDATA[Izloženost piretroidnim i organofosfatnim insekticidima u djece - procjena rizika od štetnih učinaka na neuropsihološki razvoj i hormonski status]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1209</user_id><user_firstLast_name>Željka Babić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-1312</code><acronim><![CDATA[PyrOPECh]]></acronim><duration>12.10.2020 - 01.04.2026</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Javno zdravstvo i zdravstvena zaštita, </scie_field_hr><scie_field_en>Public health and health services, </scie_field_en><institution_hr><![CDATA[Institut za medicinska istraživanja i medicinu rada]]></institution_hr><institution_en><![CDATA[Institute for Medical Research and Occupational Health]]></institution_en><team_members_id>856213</team_members_id><team_members_names><![CDATA[ Doktorand: Marija Macan ]]></team_members_names><keywords_hr><![CDATA[insekticidi, metaboliti pesticida u urinu, procjena izloženosti hranom, procjena rizika, neuropsihološki razvoj]]></keywords_hr><keywords_en><![CDATA[insecticides, biomonitoring, dietary exposure assessment, risk assessment, neuropsychological development, pubertal development]]></keywords_en><summary_hr><![CDATA[Epidemiološka istraživanja i pokusi na životinjama upućuju na moguće štetne učinke piretroidnih (PYR) i organofosfatnih (OP) insekticida na razvoj mozga i spolni razvoj u djece, čak i pri vrlo niskim razinama izloženosti. Međutim, moguća povezanost izloženosti pesticidima s navedenim zdravstvenim parametrima malo je istraživana za razdoblje puberteta, uz nejednoznačne rezultate i znatna metodološka ograničenja, kao što su nedovoljno definirana izloženost i presječni dizajn studija.   Glavni cilj predloženog projekta je procijeniti rizik od štetnih učinaka izloženosti PYR i OP insekticidima na neuropsihološki razvoj i hormonski status dječaka u predpubertetu i pubertetu u 2-godišnjoj kohortnoj studiji, uz kontrolu za potencijalne čimbenike utjecaja, koristeći isključivo neinvazivne metode. Izloženost djece PYR i OP insekticidima procjenjivat će mjerenjem njihovih metabolita u urinu u 5. i 7. razredu osnovne škole, te procjenom unosa pesticida hranom pomoću 24-satnog prisjećanja o prehrani u pet navrata tijekom 2-godišnjeg praćenja. U 5. i 7. razredu osnovne škole procjenjivat će se neuropsihološki razvoj testiranjem pažnje, pamćenja i brzine jednostavne psihomotorne reakcije, procjenom karakteristika spavanja i neurobihevioralnog funkcioniranja, a pubertetski razvoj procjenjivat će se pomoću kliničkog pregleda (po Tanneru i Praderu), mjerenja gonadotropina u urinu te spolnih hormona (testosterona i dehidroepiandrosteron sulfata) u slini.  Očekuje se da će istraživanje doprinijeti 1) razumijevanju rizika od mogućih štetnih učinaka PYR i OP insekticida na neuropsihološki razvoj i hormonski status dječaka u pubertetu; 2) prepoznavanju nedostataka i unaprjeđenju danas raspoložive metodologije ocjenjivanja razvojne neurotoksičnosti i endokrine disrupcije u okviru regulatorne toksikologije; 3) razvoju metodologije za procjenu izloženosti pesticidima koji nemaju osobinu nakupljanja u tijelu; 4) boljoj karakterizaciji izloženosti pesticidima u hrvatskoj populaciji.  ]]></summary_hr><summary_en><![CDATA[Epidemiological studies and animal experiments indicate the potential adverse effects of exposure to pyrethroid (PYR) and organophosphate (OP) insecticides on brain and sexual development in children, even at very low exposure levels. However, limited number of studies explored these potential risks during puberty, with inconsistent results and significant methodological limitations, such as insufficiently assessed exposure and cross-sectional study design.The main objective of the proposed research is to assess the risk of PYR and OP insecticide exposure to neuropsychological development and hormonal status in prepubertal and pubertal boys in a 2-year cohort study, while controlling for potential confounders, and using only non-invasive methods.Children’s exposure to PYR and OP insecticides will be assessed by biomonitoring (analysing urinary pesticide metabolites) in the 5th and 7th grades of elementary school, and by dietary exposure assessment - 24-hour dietary recall on five occasions during 2-year follow-up. In the 5th and 7th grades, neuropsychological development will be evaluated by testing attention, memory and simple psychomotor response speed, and by assessing the characteristics of child’s sleep and behaviour. Pubertal development will be evaluated by clinical examination (according to Tanner and Prader), and urinary gonadotropins and salivary sex hormones (testosterone and dehydroepiandrosterone sulfate) measurements. The research is expected to 1) increase the knowledge on possible risks of PYR and OP insecticides’ exposure for neurodevelopment and hormonal status in pubertal boys; 2) help to recognise deficiencies and assess available methodology for evaluation of developmental neurotoxicity and endocrine disruption within the framework of regulatory toxicology; 3) improve insufficient methodology for exposure assessment of non-bioaccumulative pesticides; 4) contribute to the better characterisation of pesticide exposure in the Croatian population.]]></summary_en></project><project>
<id>9356</id><title_hr><![CDATA[Teorijske pretpostavke molekularne biologije]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4704</user_id><user_firstLast_name>Predrag Šustar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-7964</code><acronim><![CDATA[ThUMB]]></acronim><duration>01.10.2020 - 30.09.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filozofija, </scie_field_hr><scie_field_en>Philosophy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Filozofski fakultet u Rijeci]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>856122</team_members_id><team_members_names><![CDATA[ Doktorand: Aleksandar Božić ]]></team_members_names><keywords_hr><![CDATA[Gen, funkcija, prirodna selekcija, znanstveno objašnjenje, društvena spoznajna teorija, evolucija genoma, evo. očuvana područja, mehanizam, zakoni]]></keywords_hr><keywords_en><![CDATA[Gene, function, natural selection, scientific explanation, social epistemology, genome evolution, evolutionary conserved regions, mechanism, laws]]></keywords_en><summary_hr><![CDATA[Istražujemo načine utjecaja suvremene molekularne biologije na razumijevanje ključnih pojmova evolucijske biologije. Utjecaj možemo promatrati ne samo u projektima tzv. &#39;velike znanosti&#39; (big-science), prije svega, Projektu ljudskog genoma, odnosno nastavnim projektima, npr. ENCODE (ENCyclopedia Of Dna Elements), već i u mnogim projektima tzv. &#39;male znanosti&#39; (small-science). U središtu projekta bit će odnos dviju spomenutih bioloških domena – molekularne i evolucijske biologije, koji u području istraživanja (PI) filozofije biologije nije u dovoljnoj mjeri sustavno razmatran (usp., iznimno, Sarkar (2015); Doolittle (1984)).Struktura projekta je sljedeća: u prvome (1) dijelu ispitujemo kako visoko sofisticirana otkrića unutar eukariotskog genoma navode na ponovno razmatranje odgovarajućih teoretskih pojmova kao što su gen, biološka funkcija i prirodna selekcija. Ponajprije, otkrića koja se tiču mehanizma genske duplikacije, gene-sharing i mehanizama povezanih s visokim udjelom tzv. &#39;mobilne DNA&#39; te recentnih otkrića novih funkcionalnih gena u ne-kodirajućim genomskim područjima. Sva navedena otkrića zahtijevaju značajne promjene na pojmovnoj razini. Stoga želimo pokazati kako tri spomenuta ključna pojma – gen, biološka funkcija i prirodna selekcija – nisu samo povezana s dotokom novih empirijskih informacija, već su međusobno isprepletena i na teoretskoj razini. To također utječe na funkcioniranje znanstvene prakse, odnosno na znanstveno zaključivanje.U drugome (2) dijelu projekta, usredotočujemo se na različite vrste znanstvenog objašnjenja u području evolucije genoma. Naše je gledište da treba transformirati prevladavajuću mehanicističku teoriju objašnjenja, integrirajući strukturalne i etiološke vrste znanstvenog objašnjenja.Konačno, u trećem (3) dijelu, koristeći recentne znanstvene studije/analize slučaja (case-studies), istražujemo način na koji znanstvene odluke i rezultati utječu na šire javno razumijevanje funkcioniranja znanosti o živim sustavima.]]></summary_hr><summary_en><![CDATA[In this project, we examine the ways in which contemporary molecular biology is influencing the understanding of some of the key-notions in evolutionary biology. The influence in question can be traced not only in ‘big-science’ projects, most notably, the Human Genome Project (HGP) and its follow-ups, e.g., the Encyclopedia of DNA Elements (ENCODE), but also in many ‘small-science’ research projects. In that regard, we focus on the exchange between these two main biological domains as a less explored layer in philosophy of biology. Accordingly, our project is structured as follows: in Part 1, we examine how discoveries of intricate workings within eukaryotic genomes, in particular, the human genome, have clearly suggested to rethink the corresponding more theoretical notions of a gene, biological function and natural selection. Namely, the discoveries concerned with the mechanisms of gene duplication and gene sharing, then, extremely large portions of mobile DNA elements within eukaryotic genomes and, for instance, new functional genes arising from non-coding regions, all call for significant accommodations at the corresponding conceptual level. The notion of gene is closely associated with the notion of biological function, which, depending on the account endorsed, can be defined with reference to natural selection. Accordingly, we show how these three notions are theoretically intertwined in many interesting ways, which also influence scientific practice. In Part 2 of the project, we single out distinct types of explanatory practices in the area of genome evolution. We claim that, in this regard, we should overcome the standard view of mechanistic explanation and adopt an appropriate level of explanatory integration between structural and etiological explanations. Finally, in Part 3, through some recent case-studies, we explore how scientific decision-making and dissemination of scientific results relate to the public understanding of the life sciences.]]></summary_en></project><project>
<id>9358</id><title_hr><![CDATA[Multimodalni prikaz molekularnih zbivanja tijekom oporavka mišjeg mozga nakon ishemijskog oštećenja]]></title_hr><title_en><![CDATA[]]></title_en><user_id>7297</user_id><user_firstLast_name>Srećko Gajović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-6790</code><acronim><![CDATA[RepairStroke]]></acronim><duration>01.11.2020 - 01.11.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>861751</team_members_id><team_members_names><![CDATA[ Doktorand: Rok Ister ]]></team_members_names><keywords_hr><![CDATA[moždani udar, miš, snimanje magnetskom rezonancijom, snimanje bioluminiscencijom, upala]]></keywords_hr><keywords_en><![CDATA[stroke, mouse, magnetic resonanse imaging, bioluminescence imaging, inflammation]]></keywords_en><summary_hr><![CDATA[Moždani udar predstavlja vodeći zdravstveni problem, te postoji potreba razumijevanja mehanizma oporavka i mogućeg liječenja mozga nakon moždanog udara. Ovim projektom pokušava se razjasniti slijed zbivanja tijekom oporavka mozga primjenom multimodalnog prikaza molekularnih zbivanja u mozgu živog miša. To će se postići primjenom niza modaliteta snimanja živih miševa magnetskom rezonancijom, te pretkliničkim optičkim snimanjem bioluminiscencije. Eksperimentalnim zatvaranjem srednje moždane arterije postići će se ishemijsko oštećenje mišjeg mozga. Procesi koji će biti promatrani uključuju upalu (praćenu bioluminiscencijom Tlr2-luc transgeničnog miša), stvaranje novih nastavaka živčanih stanica (praćenu bioluminiscencijom Gap43-luc transgeničnog miša), apoptozu (praćenu zatočenim DEVD-luciferinom), poremećaj i obnovu povezanosti mozga (difuzijskim tenzornim snimanjem magnetskom rezonancijom), te obnovu perfuzije mozga (označavanjem spina u arterijama tijekom snimanja magnetskom rezonancijom) , čijom kombinacijom se očekuje uočiti kritična molekularna i stanična zbivanja koja djeluju neuroprotektivno i obnavljaju mozak. Snimanja živog miša korelirat će se s funkcionalnim i morfološkim analizama mišjeg mozga mikroskopijom i testovima ponašanja životinja. Ovim će se omogućiti definiranje parametara oporavka mozga u mišjem modelu moždanog udara kako bi se pretklinički provjerili mogući terapijski pristupi i omogućila njihova translacija u kliničke pokuse.]]></summary_hr><summary_en><![CDATA[Stroke is the leading health problem, hence a need to understand the mechanism of recovery and possible treatment of the brain dammaged by stroke. This project attempts to clarify the sequence of events during the brain recovery after ischemic lesion by using in vivo multimodal molecular imaging of the mouse brain. This will be achieved through a combination of imaging modalities including magnetic resonance imaging (MRI), and preclinical optical bioluminescence imaging (BLI). Mouse stroke model of the middle cerebral artery occlusion (MCAO) will result in the ischemic brain damage. The processes that will be monitored include inflammation (visualized by bioluminescence of TLR2-luc transgenic mouse), extension of neuronal processes (visualized by bioluminescence of GAP43-luc transgenic mouse), apoptosis (followed by caged DEVD-luciferin), brain connectivity (MR diffusion tensor imaging), and brain perfusion (MRI arterial spin labeling), which combination is expected to describe critical molecular and cellular events that act neuroprotective and regenerate brain. In vivo imaging will be correlated with functional and morphological analysis of the mouse brain using microscopy and behavioral tests. This will allow to define the preclinical parameters of recovery of the brain in a mouse model of stroke to be used to evaluate possible therapeutic approaches and enable their translation into the clinical trials.]]></summary_en></project><project>
<id>9359</id><title_hr><![CDATA[Geni spužvi povezani s nastankom raka]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1193</user_id><user_firstLast_name>Helena Ćetković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-5135</code><acronim><![CDATA[CanSponGE]]></acronim><duration>13.10.2020 - 21.11.2025</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>856260</team_members_id><team_members_names><![CDATA[ Doktorand: Antea Talajić ]]></team_members_names><keywords_hr><![CDATA[evolucija, Metazoa, Porifera, spužve, tumori, evolucija raka, geni povezani s nastankom raka]]></keywords_hr><keywords_en><![CDATA[evolution, basal metazoans, Porifera, sponges, tumors, cancer evolution, cancer-related genes]]></keywords_en><summary_hr><![CDATA[Proučavanje ljudskih bolesti korištenjem životinja kao eksperimentalnih modela ključno je za razumijevanje uzroka, biologije i prevencije bolesti. Malo se zna o genima povezanim s nastankom raka kod beskralježnjaka, osobito kod najjednostavnijih životinja - &#39;&#39;bazalnih&#39;&#39; Metazoa. Posljednjih nekoliko godina raste zanimanje za proučavanje evolucije gena povezanih s nastankom raka budući da je široki repertoar tih gena već prisutan u genomima morfološki jednostavnih životinja. Većina ovih gena pojavila se tijekom dva glavna evolucijska događaja – s pojavom eukariota i pri prelasku u višestaničnost, tj. nastanku životinja. Stoga proučavanje gena povezanih s nastankom raka kod ljudi na nivou jednostavnijih organizama, kao što su spužve, jedna od najstarijih skupina životinja, pruža bolji uvid u njihovu evoluciju i osnovnu fiziološku funkciju. Spužve su morfološki najjednostavnije životinje, bez bilateralne simetrije, tkiva i organa, koje su se vrlo malo mijenjale tijekom evolucije. Usprkos tome, posjeduju kompleksan genom u kojem većina gena pokazuje visoku sačuvanost s homolozima kod kralježnjaka te stoga daju najbolji uvid u svojstva genoma i proteoma pretka svih Metazoa. Cilj projekta je identificirati i okarakterizirati spužvine proteine čiji su homolozi kod čovjeka povezani s nastankom raka kako bi dobili što bolji uvid u evoluciju raka. Ovakav inovativni pristup na relativno jednostavnom modelu pružit će nam uvid u osnovne fiziološke funkcije gena povezanih s nastankom raka, prije njihove diverzifikacije i specijalizacije kroz evoluciju životinja. Naše istraživanje gena spužvi povezanih s nastankom raka pomoći će u razjašnjavanju složenijih interakcija njihovih homologa kod ljudi i time objasniti moguće razloge njihovog onkogenog potencijala. Zbog važnog evolucijskog položaja spužvi na samoj bazi filogenetskog stabla životinja, svaki novi uvid u svojstva njihovih homologa povezanih s rakom poboljšat će naše razumijevanje ove bolesti kod ljudi.]]></summary_hr><summary_en><![CDATA[The use of animals as experimental models for human diseases is imperative for understanding the causes, biology, and prevention of diseases. To date, little is known about the functions of cancer-related genes in invertebrates, especially in non-bilaterian Metazoa. In the last few years, the interest in genes associated with cancer from an evolutionary perspective is increasing, since it has been shown that many of them were already present in simple non-bilaterian animals. The majority of these genes appeared in two major evolutionary transitions - the emergence of eukaryotes and the transition to multicellularity in the animal lineage. Therefore, studying cancer-related genes in organisms at the base of Metazoa, such as sponges, can help unravel the original function as well as the evolution of those genes. Sponges are morphologically simple animals, with no tissues and organs, which have changed little during evolution. Despite that, sponges possess complex genomes with many genes highly similar to their vertebrate homologs. Therefore, they provide an invaluable insight into the metazoan last common ancestors’ genome and proteome features. The aim of the proposed project is to identify and characterize sponge homologs of human cancer-related genes and thus gain a clearer picture of the evolution of cancer. Such an innovative approach using a simple model system will provide insights into the original ancestral physiological functions of cancer-related genes before their diversification and specialization in &#39;&#39;higher&#39;&#39; animals. Our understanding of the basic physiological properties of cancer-related genes in simple animals will aid in unravelling complex interactions of their human homologs and thus elucidate possible causes of their oncogenic potential. Due to the &#39;&#39;basal&#39;&#39; phylogenetic position of sponges within animals, new insights in the properties of their cancer-related homologs will substantially improve our understanding of this disease.]]></summary_en></project><project>
<id>9360</id><title_hr><![CDATA[Razotkrivanje strukture hadrona pomoću tvrdih ekskluzivnih procesa]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5888</user_id><user_firstLast_name>Kornelija Passek-Kumerički</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-9883</code><acronim><![CDATA[REVESTRUCTURE]]></acronim><duration>22.01.2021 - 21.07.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>863811</team_members_id><team_members_names><![CDATA[ Doktorand: Nikola Crnković ]]></team_members_names><keywords_hr><![CDATA[teorijska fizika visokih energija, QCD, struktura hadrona, tvrdi ekskluzivni procesi, perturbativni račun, generalizirane partonske distribucije]]></keywords_hr><keywords_en><![CDATA[theoretical high-energy physics, QCD, hadron structure, hard exclusive processes, perturbative calculation, generalized parton distributions]]></keywords_en><summary_hr><![CDATA[Nukleoni (protoni i neutroni koji su građevni blokovi materije koja nas okružuje), pioni, kaoni i drugi hadroni sastoje se od kvarkova i gluona, čije su interakcije dobro opisane teorijom jakih interakcija, tj. kvantnom kromodinamikom. No  sveobuhvatno razumijevanje dinamike vezanih stanja hadrona i njihove strukture je još uvijek neuhvatljivo i izazovno. Štoviše, u akceleratorima čestica istraživanja Standardnog modela (SM) i istraživanja fizike izvan SMa se provode uglavnom koristeći protone i rastuća  točnost tih mjerenja  zahtijeva  sve bolji opis  strukture hadrona. U projektu REVESTRUCTURE istražit ćemo strukturu hadrona proučavanjem tzv. tvrdih ekskluzivnih procesa. Budući da se ti procesi izvode pri visokim energijama gdje jaka sila postaje slaba, u opisu partonskih potprocesa se može koristiti perturbativni pristup, a faktorizacija visoko i nisko energijske dinamike omogućuje nam pristup opisu hadrona preko distribucijskih amplituda i generaliziranih partonskih distribucija. Ovi potonji objekti fenomenološki su posebno zahvalni jer potencijalno nude trodimenzionalnu (3D) sliku hadrona za razliku od 1D slike dobivene iz dobro poznatih partonskih distribucijskih funkcija koje se susreću u duboko neelastičnom raspršenju. Predloženo fenomenološko istraživanje je pravovremeno jer je u zadnje vrijeme eksperimentalna aktivnost vrlo živa: mnogo podataka je već dostupno ili se očekuje u bliskoj budućnosti od  JLab i COMPASS (CERN) grupa, a planirana su i nova postrojenja (EIC u SAD-u, LHeC u CERN-u). Mi planiramo razviti odgovarajuće softverske alate, poboljšati teorijski opis izmjerenih procesa i analizirati nove procese koji bi se mogli mjeriti. Teorijske ćemo rezultate usporediti s dostupnim eksperimentalnim podacima i koristeći prilagodbe ćemo dobiti nove informacije o strukturi hadrona. A sve to bi trebalo omogućiti značajan korak k boljem razumijevanju hadrona.]]></summary_hr><summary_en><![CDATA[Nucleons, i.e., protons and neutrons that are the building blocks of the matter that surrounds us, pions, kaons and other hadrons consist of quarks and gluons, whose interactions are well described by the theory of strong interactions, i.e. quantum chromodynamics. But the comprehensive understanding of the bound state dynamic of hadrons and their structure is still elusive and challenging. Moreover, the experiments in particle accelerators used for Standard Model (SM) and beyond SM research are performed mostly using protons with ever higher accuracy demanding ever better description of hadron structure. In REVESTRUCTURE project we will investigate hadron structure by studying the, so-called, hard exclusive processes. Since these processes are performed at high energies where the strong force becomes weak the perturbative approach can be used in the description of the parton subprocesses and the factorization of the high and low energy dynamics enables us to access the hadron description of hadrons in terms of distribution amplitudes and generalized parton distributions. The latter objects are phenomenologically especially rewarding offering potentially a three-dimensional (3D) picture of hadrons in contrast to 1D obtained from well-known parton distribution amplitudes encountered in deeply inelastic scattering. Proposed phenomenological investigation is timely due to a recent vibrant experimental activity: a lot of data is already available or expected in the near future from JLab and COMPASS (CERN) groups, and new facilities are planned (EIC in USA, LHeC at CERN). We plan to develop the required software tools, to improve the theoretical description of the measured processes, and to analyze new processes to be measured in the future. We will confront the theoretical results with the available experimental data and through fits we will extract new informations about hadron structure. All this should make a significant step towards better understanding of hadrons.]]></summary_en></project><project>
<id>9361</id><title_hr><![CDATA[Razdvajanje uticaja parametara u inžinjerskom modeliranju s parametarskom identifikacijom]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6013</user_id><user_firstLast_name>Neira Torić Malić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-9580</code><acronim><![CDATA[SEPAEMPI]]></acronim><duration>04.11.2020 - 05.11.2025</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Građevinarstvo, </scie_field_hr><scie_field_en>Civil engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Građevinski fakultet u Rijeci]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Civil Engineering]]></institution_en><team_members_id>861729</team_members_id><team_members_names><![CDATA[ Doktorand: Tea Sulovsky ]]></team_members_names><keywords_hr><![CDATA[beton, puzanje, konstrukcija, sistemski model, inverzni model, separacija parametara]]></keywords_hr><keywords_en><![CDATA[concrete, creep, structure, system model, inverse model, parameter separation]]></keywords_en><summary_hr><![CDATA[Što se tiče puzanja betona, cilj ovog istraživanja je eksperimentalno i numerički istražiti interakciju različitih procesa vezanih uz vremenski ovisnu deformaciju betona. Trenutno ne postoji eksperimentalna i numerička studija u kojoj se istražuju aspekti interakcije vremenske deformacije betona radi boljeg razumijevanja puzanja betona.Potrebno je formulirati poseban postupak za izdvajanje relevantnih parametara iz neizravnih mjerenja, tzv. “inverzna procedura”. Glavna poteškoća s inverznom procedurom je u tome što je općenito nestabilna, tj., osjetljiva na pogreške u mjerenjima.Novost predloženog projekta je razvoj postupka koji bi mogao odvojiti utjecaj pojedinih parametara u modelu. Postoje metode koje se već koriste u tu svrhu, ali nisu prikladne za građevinske materijale jer se temelje na velikim skupovima podataka. Ovdje nemamo veliki broj rezultata ispitivanja; problem ćemo prevladati proizvodnjom vlastitih eksperimenata i postupaka koji se temelje na kombinaciji determinističkog i stohastičkog opisa materijala.]]></summary_hr><summary_en><![CDATA[Regarding the creep of concrete, the aim of the present research project is to experimentally and numerically investigate the interaction between different processes related to the time-dependent deformation of concrete.  Currently there is no experimental and numerical study in which interaction aspects of time deformation of concrete is investigated in order to better understand creep of concrete.Special procedure has to be formulated for extraction of relevant parameters from indirect measurements, the so called “inverse procedure”. The main difficulty with inverse procedure is that it is generally unstable, i.e., sensitive to errors in measurements.Novelty of the proposed project is development of a procedure that could separate the influence of certain parameters in the model. There are methods that are already used for that purpose but are not suitable for civil engineering materials because they are based on large data sets. Here, we do not have a vast number of test results; we are going to overcome the problem by producing own experiments and procedures based on a combination of deterministic and stochastic material description.]]></summary_en></project><project>
<id>9363</id><title_hr><![CDATA[Kontrola neurodegeneracije moduliranjem sprege između upale i proteinopatije]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4630</user_id><user_firstLast_name>Ivana Munitić </user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-8703</code><acronim><![CDATA[ImmunoModifyCNS]]></acronim><duration>15.10.2020 - 13.06.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Interdisciplinarno područje znanosti</scie_area_hr><scie_area_en>Interdisciplinary scientific area</scie_area_en><scie_field_hr>Biotehnologija u biomedicini, </scie_field_hr><scie_field_en>Biotechnology in Biomedicine, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Fakultet biotehnologije i razvoja lijekova]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Biotechnology and Drug Development]]></institution_en><team_members_id>861732</team_members_id><team_members_names><![CDATA[ Doktorand: Josip Peradinović ]]></team_members_names><keywords_hr><![CDATA[neuroinflamacija, neurodegeneracija, optineurin, TBK1, IFN-beta]]></keywords_hr><keywords_en><![CDATA[neuroinflammation, neurodegeneration,  optineurin, TBK1, IFN-beta]]></keywords_en><summary_hr><![CDATA[Dva obilježja zajednička svim neurodegenerativnim bolestima su kronična neuroinflammacija i proteinopatija, procesi koji se aktivno međusobno amplificiraju. Mutacije u optineurinu, adaptorskom proteinu koji regulira različite stanične funkcije poput prijenosa signala tijekom upale i autofagije, pronađene su u amiotrofičnoj lateralnoj sklerozi (ALS) i frontotemporalnoj demenciji (FTD). Da bismo istražili ulogu optineurina u neurodegeneraciji prilikom ALS/FTD-a, razvili smo mišji model u kojem smo izrezali regiju kojom veže ubiquitin, time oponašajući C-terminalne delecije pronađene u bolesnika. Zanimljivo je da su u bolesnika s ALS-om i FTD-om nedavno pronađene mutacije i u proteinskim partnerima optineurina, poput Tank binding kinaze 1 (TBK1), što sugerira da djeluju u zajedničkom neuroprotektivnom putu. Ovdje ćemo pratiti dva ključna opažanja iz naše početne karakterizacije modela Optn470T gdje smo ustanovili da nedostatak funkcionalnog optineurina umanjuje aktivnost TBK1 i produkciju IFN-ß u stanicama mikroglije i makrofaga, dovodeći do neravnoteže u proupalnim i protuupalnim čimbenicima, te da su ostarjeli Optn470T miševi razvijaju patognomonične ALS/FTD agregate u frontalnom korteksu, koji sadrže TDP-43 i ubikvitin. U ovom projektu planiramo 1) primijeniti nove CRISPR modele stanične deficijencije optineurina kako bismo razjasnili spregu između agregacije proteina i upale in vitro, te  2) manipulirati tijek bolesti u in vivo ALS/FTD modelu odabranim genetskim i virusnim metodama. Nadalje, na temelju naših rezultata da je optineurin ključni regulator imunomodulacijskog IFN-ß citokina, posebna pažnja će biti stavljena na pokušaj terapijskog apliciranja IFN-ß intratekalno pomoću genske terapije s AAV 2/9. Budući da je optineurin neuroprotektivna molekula na raskrižju upale i proteinopatije, nadamo se da ćemo točnim molekularnim razjašnjenjem njengove neuroprotektivne uloge, identificirati najprikladnije putove za terapijsku manipulaciju.]]></summary_hr><summary_en><![CDATA[Two hallmarks common to all neurodegenerative diseases are chronic neuroinflammation and proteinopathy, processes that actively amplify each other. Mutations in optineurin, an adaptor protein implicated in various cellular functions including inflammatory signalling and autophagy, have been found in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). To investigate the mechanistic role of optineurin in neurodegeneration in ALS/FTD, we have generated a mouse model in which the ubiquitin-binding region of optineurin was deleted, mimicking C-terminal truncations found in patients. Interestingly, optineurin-interacting proteins, such as Tank binding kinase 1 (TBK1), have also recently been found in ALS and FTD patients, suggesting that they participate in a shared neuroprotective pathway. Here we will follow-up two key observations from our initial characterization of the Optn470T model where we found that the lack of functional optineurin precluded optimal TBK1 activation and IFN-ß production in microglia and macrophages, leading to a disbalance in proinflammatory and anti-inflammatory factors, and that aged Optn470T mice developed pathognomonic ALS/FTD aggregates containing TDP-43 and ubiquitin in their frontal cortices. To this end, we will 1) apply novel CRISPR-generated cellular systems of optineurin deficiency to elucidate the crosstalk between protein aggregation and inflammation in vitro, and 2) manipulate the disease course in the in vivo ALS/FTD models by selected genetic and viral tools. In particular, based on our results that optineurin is a key regulator of the immunomodulatory IFN-ß pathway, a special focus will be to deliver IFN-ß intrathecally by adenovirus-associated virus 2/9 gene therapy. Overall, by addressing several outstanding questions on optineurin, a neuroprotective molecule at the crossroads of inflammation and proteinopathy, we intend to pinpoint the most likely pathway(s) for therapeutic manipulation.]]></summary_en></project><project>
<id>9364</id><title_hr><![CDATA[Nesigurnost modeliranja odziva broda na valovima Jadranskog mora]]></title_hr><title_en><![CDATA[]]></title_en><user_id>810</user_id><user_firstLast_name>Joško Parunov</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-9233</code><acronim><![CDATA[MODUS]]></acronim><duration>01.10.2020 - 02.11.2025</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Brodogradnja, </scie_field_hr><scie_field_en>Naval architecture, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>861728</team_members_id><team_members_names><![CDATA[ Doktorand: Tamara Petranović ]]></team_members_names><keywords_hr><![CDATA[valovi, brod, Jadransko more, mjerenja u naravi, nesigurnost modeliranja, umjetna inteligencija]]></keywords_hr><keywords_en><![CDATA[waves, ship, Adriatic Sea, full scale measurements, modelling uncertainty, artificial inteligence]]></keywords_en><summary_hr><![CDATA[U projektu se analiziraju dvije ključne nesigurnosti modeliranja  odziva broda na uzburkanom moru, tj. nesigurnost u modeliranju valova i nesigurnosti numeričkih proračuna pomorstvenosti broda. Svrha projekta je poboljšati razumijevanje i kvantificirati nesigurnosti modeliranja u predviđanju kratkoročnih i dugoročnih odziva broda. Nesigurnosti modeliranja koriste se u raznim problemima temeljenim na metodama pouzdanosti i rizika, kao što su analiza operabilnosti broda i optimiranje plovidbenih ruta, odlučivanje pri manevriranju broda u  nepovoljnim vremenskim prilikama i projektiranje brodske konstrukcije na osnovama metoda pouzdanosti. Projektom se određuju nesigurnosti odziva broda na valovima Jadranskog mora, iako se primijenjene metode i dobiveni rezultati mogu generalizirati i na druge akvatorije. Glavne aktivnosti u projektu su mjerenja u naravi, numerički proračuni  korištenjem metoda pomorstvenosti i primjena umjetne inteligencije za predviđanje odziva broda. Praktična primjena rezultata će se prikazati kroz analizu operabilnosti broda u Jadranskom moru,  temeljenu na metodama rizika.]]></summary_hr><summary_en><![CDATA[The project deals with two crucial types of the modelling uncertainties in predicting ship response in stochastic seaway, namely uncertainty in modelling wave data and uncertainty in theoretical seakeeping computations. The project is intended to improve understanding and quantification of modelling uncertainties in prediction of short- and long-term stochastic responses of ship in a seaway that may have different practical applications. Quantified uncertainties are typically used in ship reliability- and risk-based analyses as operability analysis and weather routing, heavy weather manoeuvring, risk-based ship operation and reliability-based ship structural design. The project covers description of the wave environment in the Adriatic Sea, although methods and obtained results may be generalized to other wave environments. Main activities in the project consist of full-scale measurements, numerical computations using standard seakeeping tools and application of artificial intelligence for ship response prediction. Practical application of results to the risk-based  ship operability analysis in the Adriatic Sea will be demonstrated. ]]></summary_en></project><project>
<id>9365</id><title_hr><![CDATA[Integrin alpha V beta 5-povezane fokalne i retikularne adhezije u melanomu]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1211</user_id><user_firstLast_name>Andreja Ambriović Ristov</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-9656</code><acronim><![CDATA[AdMeFoRe]]></acronim><duration>13.10.2020 - 12.10.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>856302</team_members_id><team_members_names><![CDATA[ Doktorand: Marija Tomić ]]></team_members_names><keywords_hr><![CDATA[melanom, integrin alpha V beta 5, adhesom, kompleks adhezije integrina, fokalna adhezija, retikularna adhezija, paklitaksel, migracija, invazija]]></keywords_hr><keywords_en><![CDATA[melanoma, integrin alpha V beta 5, adhesome, integrin adhesion complex, focal adhesion, reticular adhesion, paclitaxel, migration, invasion]]></keywords_en><summary_hr><![CDATA[Ciljana terapija i/ili inhibitori imunosnih kontrolnih točaka neuspješni su pri liječenju velikog broja bolesnika s melanomom te se oni liječe klasičnim protutumorskim lijekovima, poput paklitaksela (PTX) koji nije toliko učinkovit u melanomu kao što je to slučaj u drugim tipovima tumora. Ne postoje lijekovi za inhibiciju pokretljivosti, a time i invaziju i širenje stanica melanoma. Stoga, postoji hitna potreba za razvojem inovativnih metoda za poboljšanje učinkovitosti PTX i za inhibiciju metastaziranja. Integrini, receptori na površini stanica, predstavljaju potencijalne ciljne molekule za tu svrhu. Vezanje integrina alpha v beta 5 na izvanstanični matriks dovodi do stvaranja velikih kompleksa proteina povezanih s membranom nazvanih fokalne adhezije (FA) i novootkrivenih kompleksa nazvanih retikularne adhezije (RA). Naši nedavno objavljeni podaci pokazali su, u dvije stanične linije melanoma, da utišavanje integrinske podjedinice alpha V povećava osjetljivost na PTX i istodobno smanjuje migraciju i invaziju stanica, a učinak smo pripisali integrinu alpha V beta 5. Analizirali smo sastav kompleksa adhezije i otkrili da obje stanične linije melanoma pretežno koriste integrin alpha V beta 5 i, nakon utišavanja integrina alpha V, identificirali specifične proteine u kompleksu adhezije. Hipoteza ovog projekta je da proteini integrin alpha V beta 5-povezanih FA ili RA mogu predstavljati izvrsne mete za povećanje osjetljivosti na PTX, smanjenje migracije i invazije stanica melanoma. U okviru ovog projekta analizirat ćemo molekularni sastav FA i RA te ulogu njihovih komponenti u stvaranju FA ili RA, citoskeleta aktina i mikrotubula, osjetljivosti stanica na PTX, migraciji i invaziji dviju staničnih linija melanoma. Ovaj će projekt povećati temeljna znanja o FA i RA i ima potencijal otkriti nove ciljne molekule koje bi se mogle koristiti u terapiji melanoma.]]></summary_hr><summary_en><![CDATA[Targeted agents and/or immune checkpoint inhibitors still fail in a substantial portion of melanoma cases and patients are treated with conventional antitumor drugs, such as paclitaxel (PTX) which is usually not as effective for melanoma as it is for some other types of tumours. There are no drugs available that inhibit motility, invasion and dissemination of melanoma. Therefore, there is an urgent need to develop innovative methods for improving effectiveness of PTX and to inhibit metastasis. Integrins, receptors on the cell surface, are the potential target molecules for this purpose. Ligation of integrin alpha V beta 5 to extracellular matrix leads to formation of large membrane-associated complexes called focal adhesions (FA) and newly discovered reticular adhesions (RA). Our recently published data has shown, in two melanoma cell lines, that the knockdown of integrin subunit alpha V increases the sensitivity to PTX and concurrently decreases cell migration and invasion and we ascribed this effect to integrin alpha V beta 5. We analysed the composition of adhesion complexes and discovered that both melanoma cell lines predominantly use integrin alpha V beta 5 and, upon integrin alpha V knockdown, we identified specific proteins within adhesion complexes. The hypothesis of this project is that proteins of the integrin alpha V beta 5-associated FA or RA may serve as excellent targets to achieve increased sensitivity to PTX, and, concurrently, decreased cell migration and invasion. Within this project we will reveal the molecular composition of integrin alpha V beta 5-associated FA and RA and analyse the role of its components in formation of FA and RA, actin and microtubule cytoskeletons, cell sensitivity to PTX, migration and invasion in two melanoma cell lines. This project will increase the fundamental knowledge on FA and RA, and has the potential to identify new target molecules within adhesion proteins that might be used in melanoma therapy.]]></summary_en></project><project>
<id>9367</id><title_hr><![CDATA[Porijeklo i taloženje sedimenata u vrijeme kasno kvartarnih promjena morske razine: Sustav rijeke Krke i Srednjojadranske kotline]]></title_hr><title_en><![CDATA[]]></title_en><user_id>162</user_id><user_firstLast_name>Slobodan Miko</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-7883</code><acronim><![CDATA[QMAD]]></acronim><duration>24.08.2020 - 22.11.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Geologija, </scie_field_hr><scie_field_en>Geology, </scie_field_en><institution_hr><![CDATA[Hrvatski geološki institut]]></institution_hr><institution_en><![CDATA[Croatian Geological Survey]]></institution_en><team_members_id>855846</team_members_id><team_members_names><![CDATA[ Doktorand: Natalia Šenolt ]]></team_members_names><keywords_hr><![CDATA[promjene morske razine, pleistocene, holocen, srednjojadranska kotlina, paleoklima, geomorfologija podmorja, sedimenti, stratigrafija, aDNA]]></keywords_hr><keywords_en><![CDATA[sea level rise, Pleistocene, Holocene, Mid Adriatic Deep, paleoclimate, sediments, palynology, stratigraphy, marine geomorphology, aDNA]]></keywords_en><summary_hr><![CDATA[This project is set to gain insights and improve the very limited knowledge related to submerged karst paleolandscapes of the Eastern Adriatic Shelf and the Late Quaternary sedimentary sequences along the eastern part of the Mid Adriatic Deep (MAD, Jabuka Pit). The study of the Pleistocene deltaic plains of Krka River will provide an insight into stratigraphic sequence with development of deltaic systems and estuaries, produced by the interplay of eustatic sea level fluctuations and local factors such as sediment supply and tectonic activity. The continuous marine sedimentation during the Late Quaternary will be investigated in the MAD. The role of sediment inflow from Krka River catchment to the Eastern MAD could have been significant during LGM. Using geophysics, sedimentology, micropaleontology, geochemistry and aDNA analysis, the paleoenvironmental evolution will be tracked from fluvial/lacustrine to deeper marine environments, on a short transect less than 100 km in length (Lake Prokljan in the Krka River estuary to Eastern MAD). This suite of analyses will produce climate and environmental proxy data, as well as offer insights into the Late Upper Paleolithic hunters and gatherers migration and environmental adaptation along the Eastern Adriatic coast were a relatively short-lived Krka delta plain probably existed. The dated sea level and landscape changes will help to reconstruct possible human contacts between different regions during Falling, Lowstand and Transgressive System Tracts and decipher the possible role of the Krka River as a land/floodplain bridge. Special attention will be paid to potential anthropogenic environments, recent sedimentation rates and landscape features, as well as determination of fluxes of both organic carbon and terrestrial sedimentary components and potentially toxic elements. ]]></summary_hr><summary_en><![CDATA[Predloženi projekt ima za cilj unaprijediti spoznaje do sada slabo istražene potopljene krajolike istočno-jadranskog šelfa, kao i kasno-kvartarnih sedimenata istaloženih duž istočnog dijela Srednjojadranske kotline (MAD, Jabučka kotlina). Istraživanje pleistocenske naplavne ravnice rijeke Krke dati će uvid u stratigrafski slijed sedimenata s razvojem deltnog sustava i estuarija, koji su nastali interakcijom eustatskih promjena razine mora i lokalnih faktora poput donosa sedimenata i tektonske aktivnosti. Kontinuirana morska sedimentacija tijekom kasnog kvartara, te donos materijala iz slivnog područja rijeke Krke, biti će istražen na prostoru istočnog dijela MAD-a. Primjenom geofizičkih metoda visoke rezolucije, te sedimentoloških, petrofizičkih, geokemijskih, mikropaleontoloških i aDNA metoda na uzorcima iz jezgara sedimenata, po prvi puta će se moći pratiti paleookolišna evolucija od riječnih/jezerskih do dubljemorskih okoliša na profilu kraćem od 100 km (od jezera Prokljan u estuariju rijeke Krke do istočnog MAD-a). Prepoznat će se odgovarajući klimatski i okolišni pokazatelji, te će se dobiti uvid u migraciju i okolišnu prilagodbu lovaca i sakupljača koji su tijekom kasnog paleolitika obitavali na istočnoj obali Jadrana, gdje je vjerojatno postojala naplavna ravnica rijeke Krke. Dobiveni rezultati o promjenama morske razine i krajolika omogućit će razumijevanje moguće interakcije među ljudima sa šireg istraživanog prostora u vrijeme sustavnih traktova padajuće, niske i rastuće razine mora. Time će se istražiti moguća uloga rijeke Krke kao kopnenog/naplavnog „mosta“ za ljudsku migraciju. Posebna pažnja bit će posvećena procjeni recentne brzine sedimentacije, prepoznavanju obilježja potopljenih krajolika, te također izračunu brzine akumulacije organskog ugljika i kopnenih komponenata sedimenata, te potencijalno toksičnih elemenata. ]]></summary_en></project><project>
<id>9372</id><title_hr><![CDATA[Sferni optički mikrorezonatori za senzoriku, lasere i nelinearnu optiku]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4296</user_id><user_firstLast_name>Davor Ristić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-7873</code><acronim><![CDATA[SOMSLNO]]></acronim><duration>08.12.2021 - 07.12.2025</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>865283</team_members_id><team_members_names><![CDATA[ Doktorand: Snigdha Thekke Thalakkal ]]></team_members_names><keywords_hr><![CDATA[Optički mikrorezonatori, modovi šapučuće galerije, laseri, senzor plina, nelinearna optika]]></keywords_hr><keywords_en><![CDATA[Optical microresonators, whispering gallery modes, lasers, gas sensors, non-linear optics]]></keywords_en><summary_hr><![CDATA[Projekt SOMSLNO obuhvaćat će proizvodnju, karakterizaciju i funkcionalizaciju sfernih optičkih mikrorezonatora (mikrosfera). Iskoristit će se već postojeći eksperimentalni postav na Institutu Ruđer Bošković (IRB) koji omogućuje proizvodnju visokokvalitetnih (Q> 10^7) optičkih mikrorezonatora od kvarcnog stakla i njihovu karakterizaciju. Projekt će obuhvatiti nadogradnju eksperimentalnog postava kako bi se omogućilo mjerenje nelinearnih optičkih efekata u mikrorezonatorima i oblaganje mikrorezonatora s optički aktivnim i pasivnim slojevima. Osim mikrosfera od kvarcnog stakla, projekt će uključivati i proizvodnju mikrosfera izrađenih od teluritnih i halkogenidnih stakala. Obložene sfere proučavat će se za primjene kao senzori plina (sfere obložene poroznim silicijem), kao laseri (obložene sfere od kvarcnog i teluritnog stakla) i u nelinearnoj optici (halkogenidne sfere). Projekt će biti podijeljen u 5 ciljeva (O1-O5). O1 će se baviti konstrukcijom sustava za spregu svjetlosti u sferu pomoću prizme. Upotrijebit će se kao alternativna metoda metodi sprege pomoću suženog optičkog vlakna koja je već prisutna na IRB-u. O2 će se baviti oblaganjem mikrosfera za primjenu kao senzor plina. Sfere će biti obložene poroznim silicijevim dioksidom i bit će korištene za detekciju različitih plinova kao što su amonijak ili pare etanola. O3 će se baviti proizvodnjom sfera od halkogenidnog stakla za primjenu u nelinearnoj optici. O4 će se baviti proizvodnjom sfera dopiranih s rijetkim zemljama za primjenu kao laseri. Mikrolaseri će biti proizvedeni kako oblaganjem mikrosfera od kvarcnog stakla sol-gel dobivenim slojevima, tako i proizvodnjom sfera od teluritnog stakla dopiranih rijetkim zemljama. O5 će se baviti proučavanjem optoakustičkih vibracija mikrosfera.]]></summary_hr><summary_en><![CDATA[The scope of the SOMSLNO project will be the production, characterization and functionalization of spherical optical microresonators (microspheres). It will take advantage of the already existing experimental facilities at the Ruđer Bošković Institute(RBI) that make possible the production of high quality (Q>10^7) optical silica microresonators and their characterization. The project will include the upgrade of the experimental facilities to make possible the measurement of nonlinear optical effects in microresonators and the coating of microresonators with optically active and passive layers. In addition to silica microsphere the project will include the production of microspheres made of tellurite and chalcogenide glasses. The coated spheres will be studied for applications in gas sensing (porous silicon coated spheres), lasing (coated silica spheres and tellurite spheres) and non-linear optics (chalcogenide spheres). The project will be divided into 5 objectives (O1-O5).  O1 will deal with the construction of the prism coupling system which will be used for coupling light into and out of the sphere. It will be used in addition to the taper coupling method already present at the RBI. O2 will deal with the coating of silica microspheres for use as gas sensors. The spheres will be coated with porous silicon and will be used to sense various gasses such as ammonia or ethanol vapors. O3 will deal with the production of chalcogenide glass spheres for use in nonlinear optics applications. O4 will deal with the production of rare earth doped spheres for lasing applications. Microlasers will be produced both by coating silica microspheres with sol-gel layers and by producing rare earth doped tellurite glass spheres. O5 will deal with the study of optoacoustical vibrations of the microspheres.]]></summary_en></project><project>
<id>9373</id><title_hr><![CDATA[Modeli odgovora na odgojno-obrazovne potrebe djece izložene riziku socijalne isključenosti u ustanovama ranog i predškolskog odgoja i obrazovanja]]></title_hr><title_en><![CDATA[]]></title_en><user_id>7722</user_id><user_firstLast_name>Dejana Bouillet</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-2067</code><acronim><![CDATA[MORENEC]]></acronim><duration>01.11.2020 - 31.10.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Edukacijsko-rehabilitacijske znanosti, </scie_field_hr><scie_field_en>Physical education and rehabilitation sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Učiteljski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Teacher Education]]></institution_en><team_members_id>858385</team_members_id><team_members_names><![CDATA[ Doktorand: Marina Panić ]]></team_members_names><keywords_hr><![CDATA[rani i predškolski odgoj i obrazovanje, rizik socijalne isključenosti, etiološki i fenomenološki aspekti rizika, mjere potpore, evaluacija]]></keywords_hr><keywords_en><![CDATA[Early and Childhood Education and Care, Risk of Social Exclusion, Etiological and Phenomenological Aspects of Risks, measures of Support, Evaluation]]></keywords_en><summary_hr><![CDATA[Kumulativni činitelji rizika socijalne isključenosti se višestruko nepovoljno odražavaju na kvalitetu života i razvoja djece rane i predškolske dobi, što upućuje na potrebu definiranja njihovih potreba i problema, utvrđivanje područja u kojima je djeci i njihovim obiteljima potrebno osigurati dodatnu potporu, provjeru dostupnosti i kvalitete takve potpore, definiranje ciljeva, sadržaja i metoda potrebnog odgojno-obrazovnog djelovanja te realizaciju i evaluaciju specifičnih modela potpore. Cilj predloženog projekta je doprinijeti sistematizaciji postojećih i kreiranju novih znanstvenih spoznaja o etiološkim, fenomenološkim i intervencijskim aspektima rizika socijalne isključenosti djece rane i predškolske dobi. Ostvarivanje ovog cilja pretpostavka je daljnjeg osnaživanja ustanova RiPOO u ostvarivanju razvojnih prava djece izložene riziku socijalne isključenosti.Cilj će se ostvariti analizom etioloških, fenomenoloških i intervencijskih aspekata rizika socijalne isključenosti djece putem utvrđivanja udjela djece izložene riziku socijalne isključenosti, karakteristika njima usmjerene pedagoške prakse i dostupnih mjera potpore toj skupini obitelji i djece. Rezultati istraživanja omogućit će komparaciju i kritičku analizu inkluzivnosti ustanova ranog i predškolskog odgoja i obrazovanja (RiPOO). Istraživanje povezuje teorije i metode iz edukacijsko-rehabilitacijske i pedagogijske znanosti te kvantitativne i kvalitativne metode istraživanja, a planira se obuhvat reprezentativno odabranih 60 ustanova RiPOO u Hrvatskoj (djece, roditelja/skrbnika, odgajatelja i stručnih suradnika). Razvit će se mjerni instrumenti za utvrđivanje odgojno-obrazovnih potreba djece izložene riziku socijalne isključenosti, istražiti modeli odgovora ustanova RiPOO na te potrebe, te sistematizirati i razviti lepeza raznolikih, na pokazateljima uspješnosti temeljenih, mjera potpore djeci u sklopu RiPOO.]]></summary_hr><summary_en><![CDATA[Cumulative factors of risk of social exclusion (RSE) multiply unfavourable effect on the quality of children life in early age. That fact emphasizes the necessity for defining children needs and problems, for determination of the fields in which children and their families need support and for the analysis of availability of that support. It emphasizes the necessity for defining goals, content and methods of appropriate educational practice, and  evaluation of the specific models of the support. The objective of the proposed research is to contribute to the systematisation of current and development of new scientifically based findings regarding etiological, phenomenological and intervention aspects of RSE within children in early years. The realization of this objective is an important precondition to further empowerment of early childhood education and care institutions (ECECI) in fulfilling developmental rights of children at RSE. The objective will be achieved by the analysing of etiological, phenomenological, and intervention aspects of RSE of children through the establishing the proportion of children at RSE, characteristics of educational practices directed to these group of children, and available measures of educational support and professional treatment for these families and children. The results will enable a comparative and critical analysis of inclusivity of ECECI. The research interlinks theories and methods within educational-rehabilitation and pedagogical sciences, and quantitative and qualitative methods of data research. The plan is to include at least 60 representative ECECI (children, parents, teachers, and professional support staff). The measurement instruments for establishing educational needs of children at RSE will be developed, models of appropriate response of ECECI to such needs will be analysed, and systematization and development of a range of diverse evidence based interventions in ECECI will be provided.]]></summary_en></project><project>
<id>9375</id><title_hr><![CDATA[Karakterizacija kandidat gena za kongenitalne anomalije bubrega i urotrakta (CAKUT) tijekom razvoja u miša i čovjeka]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4338</user_id><user_firstLast_name>Sandra Kostić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-3400</code><acronim><![CDATA[CAKUT]]></acronim><duration>15.10.2020 - 16.04.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Split School of Medicine]]></institution_en><team_members_id>856258</team_members_id><team_members_names><![CDATA[ Doktorand: Nela Kelam ]]></team_members_names><keywords_hr><![CDATA[kongenitalne anomalije bubrega i urotrakta, genetika, imunohistokemija, imunofluorescencija, knock-out miš]]></keywords_hr><keywords_en><![CDATA[congenital anomalies of the kidney and urinary tract, genetics, immunohistochemistry, immunofluorescence, knock-out mice]]></keywords_en><summary_hr><![CDATA[Kongenitalne anomalije bubrega i mokraćnog sustava (CAKUT) u 40-50% pedijatrijskih bolesnika dovode do krajnjeg stadija zatajenja bubrega. Među kategorijama CAKUTa, kongenitalna opstruktivna uropatija predstavlja zajednički i teški oblik malformacija. Zbog nedostatka temeljnog uvida o njegovoj primarnoj patogenezi, dijagnostičke i terapijske mogućnosti su ograničene.Nedavno smo identificirali dominantne štetne mutacije u DSTYK genu koji kodira dvostruku serin-treonin i tirozin protein-kinazu, kod osoba s malformacijama mokraćnog sustava koristeći sekvenciranje exoma u kombinaciji s funkcionalnim modelom u zebraste ribice (New Engl J Med 2013). Protein kodiran DSTYK genom djeluje kao pozitivan regulator u signalizaciji faktora rasta fibroblasta (FGF), tijekom nefrogeneze. Osim toga, identificirali smo pet novih gena kandidata za CAKUT koji su pokazali ekspresiju u miša i čovjeka tijekom razvoja urinarnog trakta. Među tim genima, DLG1 i KIF12 su vjerojatno susceptibilni geni za razvoj CAKUTa kod ljudi (Kidney Int 2015).Ovdje predlažemo početnu karakterizaciju funkcije novih gena kandidata za CAKUT tijekom embrionalnog razvoja, nefrogeneze i razvoja uretera. Prvo ćemo istraživati profil vremenskog-prostornog izražaja i ko-lokaliziranje kandidat gena za CAKUT u različitim fazama embriogeneze u tkivima normalnih miševa i ljudskog zametka te bubrega i mokraćnog sustava u razvoju i usporediti markere nefrogeneze i razvoja uretera. Zatim ćemo odabrati jedan visoko prioritetni novi kandidat gen te generirati i okarakterizirati miša koji nosi mutaciju u ovom genu od interesa (knockout miš), zatim ćemo identificirati mehanizme kojima mutacije u ovom genu dovode do malformacija urinarnog trakta kod ljudi.Ova studija je osmišljena kako bi se okarakterizirali funkcionalni učinci kandidat gena za CAKUT u razvoju mokraćnih puteva, identificirati disregulacijske putove i na kraju osmisliti nove dijagnostičke alate i terapijske strategije za taj učestali oblik zatajenja bubrega.]]></summary_hr><summary_en><![CDATA[Congenital Anomalies of the Kidney and the Urinary Tract (CAKUT) account for 40-50% of pediatric end-stage kidney failure. Among CAKUT categories, congenital obstructive uropathy represents a common and severe form. Due to paucity of fundamental insight about its primary pathogenesis, diagnostic and therapeutic options are severely limited.  We recently identified dominant deleterious mutations in DSTYK, encoding a dual serine-threonine and tyrosine protein-kinase, in individuals with urinary tract malformations using exome sequencing combined to functional modeling in zebrafish (New Engl J Med 2013). The protein encoded by DSTYK acts as a positive regulator of fibroblast growth factor (FGF) signaling during nephrogenesis. Additionally, we identified five novel candidate genes for CAKUT that showed specific expression in the human and mouse developing urinary tract. Among these genes, DLG1 and KIF12 are likely novel susceptibility genes for CAKUT in humans (Kidney Int 2015).Here we propose to initially characterize the function of novel CAKUT candidate genes during embryonic development, nephrogenesis and ureteric development. We will first study the candidate genes temporal-spatial expression and colocalization profile during different stages of embryogenesis in normal mouse and human embryonic tissue and in developing kidneys and urinary tract and compare to markers of nephrogenesis and ureteric development. We will next choose one high-priority novel candidate gene and generate and characterize mouse harboring mutation in a gene of interest (knockout mice) to identify the mechanisms by which mutations in this gene lead to urinary tract malformations in humans. This study is designed to characterize the functional effect of CAKUT candidate genes in urinary tract development, to identify dysregulated pathways, and, ultimately, to devise novel diagnostic tool and therapeutic strategies for this common form of renal failure.]]></summary_en></project><project>
<id>9376</id><title_hr><![CDATA[Alfa satelitska DNA u evoluciji mreža genske modulacije]]></title_hr><title_en><![CDATA[]]></title_en><user_id>183</user_id><user_firstLast_name>Đurđica Ugarković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-6289</code><acronim><![CDATA[AlphaSatGenNet]]></acronim><duration>22.10.2020 - 21.04.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>861750</team_members_id><team_members_names><![CDATA[ Doktorand: Sven Ljubić ]]></team_members_names><keywords_hr><![CDATA[satelitska DNA, transkripcija, genska ekspresija, evolucija, toplinski stres, epigenetika]]></keywords_hr><keywords_en><![CDATA[satellite DNA, transcription, gene expression, evolution, heat stress, epigenetics]]></keywords_en><summary_hr><![CDATA[Satelitske DNA su uzastopno ponovljene sekvence koje se preferencijalno grupiraju unutar konstitutivnog heterokromatina. Međutim, u nekim slučajevima, one su djelomično raspršene u blizini gena unutar eukromatina. Smatra se da su takva mješovita organizacija i uzajamno djelovanje između satelitskih ponavljanja unutar heterokromatina i eukromatina odgovorni za učinak satelitske DNA na modulaciju ekspresije gena koja je prvi put pokazana u kukcu Tribolium castaneum.Primarni cilj predloženog projekta je istražiti ulogu ljudske alfa satelitske DNA u modulaciji genske ekspresije. Alfa satelitska DNA je glavna ljudska satelitska DNA smještena u (peri)centromernim područjima svih ljudskih kromosoma, a  zajednička je svim primatima. Pored (peri)centromernog položaja, bioinformatička pretraga ljudskog genoma otkriva alfa satelitska ponavljanja raspršena unutar eukromatina, uz gene, i ukazuje na sličnu genomsku organizaciju glavnog satelita kukca Tribolium castaneum i alfa satelitske DNA. Na temelju ovog zapažanja može se pretpostaviti da alfa satelitski transkripti mogu potaknuti epigenetski mehanizam koji modificira kromatin na raspršenim alfa satelitskim ponavljanjima, što dovodi do promjena u ekspresiji obližnjih gena.Koristeći eksperimentalni pristup, planiramo istražiti utjecaj glavne ljudske alfa satelitske DNA na ekspresiju susjednih gena, kao i molekularni mehanizam njenog modulatornog djelovanja  na gene. Osim toga, izvršit će se bioinformatička analiza i usporedba alfa satelitskih ponavljanja raspršenih unutar eukromatina svih sekvenciranih genoma primata kao i karakterizacija njima susjednih gena. Na temelju dobivenih podataka očekujemo da ćemo otkriti moguću ulogu alfa satelitske DNA u fiziologiji i evoluciji mreža genske modulacije u primata.]]></summary_hr><summary_en><![CDATA[Satellite DNAs are tandemly repeated sequences preferentially clustered within constitutive heterochromatin. However, in some cases, they are found partially dispersed in the vicinity of genes within euchromatin. Such mixed organization and interplay between repeats located within heterochromatin and euchromatin is proposed to be responsible for the gene-modulatory effect of satellite DNA which was first shown in the beetle Tribolium castaneum. The primary aim of the proposed project is to investigate the gene-modulatory role of human alpha satellite DNA. Alpha satellite DNA is a major human satellite located in the (peri)centromeric regions of all human chromosome and is common for all primates. In addition to (peri)centromeric location, a bioinformatics search of the human genome reveals alpha satellite repeats dispersed within euchromatin, adjacent to genes, and points to a similar genomic organization of a major Tribolium castaneum satellite and alpha satellite DNA. Based on this observation it could be proposed that alpha satellite transcripts could induce an epigenetic mechanism that modifies chromatin at dispersed alpha satellite repeats, leading consequently to changes in the expression of nearby genes.Using experimental approach, we plan to study influence of a major human alpha satellite DNA on the expression of adjacent genes as well as a molecular mechanism of its gene modulatory activity. In addition, bioinformatics analysis and comparison of alpha satellite repeats dispersed within euchromatin of all sequenced primate genomes and characterization of their associated genes will be performed. Based on obtained data we expect to reveal the possible role of alpha satellite DNA in physiology and in the evolution of gene modulatory networks in primates.]]></summary_en></project><project>
<id>9377</id><title_hr><![CDATA[Dinamika reproduktivnog i seksualnog zdravlja mladih u Hrvatskoj od 2005. do 2020. godine]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5502</user_id><user_firstLast_name>Ivan Landripet</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-6995</code><acronim><![CDATA[SERZAM2020]]></acronim><duration>02.11.2020 - 12.02.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Sociologija, </scie_field_hr><scie_field_en>Sociology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>858445</team_members_id><team_members_names><![CDATA[ Doktorand: Sandra Sevic ]]></team_members_names><keywords_hr><![CDATA[mladi, rizično ponašanje, reproduktivno i seksualnu zdravlje, religioznost, biobihevioralno istraživanje]]></keywords_hr><keywords_en><![CDATA[emerging adults, risk taking, reproductive and sexual health, religiosity, bio-behavioral study]]></keywords_en><summary_hr><![CDATA[Ovaj multidisciplinarni biobihevioralni projekt nastavlja se na dvije nacionalne studije seksualnog i reproduktivnog zdravlja mladih provedene 2005. i 2010. godine. Istraživanje ima dva cilja: (1) utvrditi trenutnu raširenost te vremensku dinamiku rizičnih seksualnih ponašanja u nacionalnoj populaciji mladih u dobi od 18 do 25 godina tijekom posljednjih 15 godina; (2) ispitati ulogu vjere i religioznosti kao zaštitnih čimbenika u kontekstu rizičnog seksualnog ponašanja. Drugi cilj projekta vezan je uz nepostojanje sustavne prevencije rizičnog seksualnog ponašanja među mladima te porast religioznosti u Hrvatskoj.Prikupljanje biobihevioralnih podataka provest će se na nacionalnom probabilističkom online panelu 1.200 osoba u dobi između 18 i 25 godina. Sve procedure u bihevioralnom dijelu studije razrađene su prema total survey error modelu. U biološkom dijelu istraživanja prikupit ćemo uzorke urina 400 slučajno odabranih seksualno aktivnih sudionika panela; informirani pristanak tražit će se odvojeno za bihevioralni i biološki dio istraživanja. Uzorke ćemo testirati na klamidijsku infekciju (kao u istraživanju iz 2010. godine) uporabom PCR metode. Jedinstveni numerički kodovi omogućit će povezivanje bioloških i bihevioralnih podataka. Svi sudionici biološkog dijela studije dobit će karticu s osobnom šifrom i uputom na koji način mogu saznati rezultat testiranja te, bude li potrebno, biti upućeni na liječenje.Očekujemo da će projektni uvidi pridonijeti razvoju empirijskim utemeljenih intervencija usmjerenih očuvanju reproduktivnog i seksualnog zdravlja mladih u Hrvatskoj.Konceptualni pristup koji koristimo za ispitivanje povezanosti između religioznosti i izloženosti seksualnim rizicima (testirajući četiri specifična mehanizma utjecaja) originalni je doprinos znanstvenoj literaturi – kako u razjašnjavanju kontradiktornih nalaza tako i unaprjeđivanjem spoznaja o odnosu između religioznosti i reproduktivnog te seksualnog zdravlja mladih.]]></summary_hr><summary_en><![CDATA[This multidisciplinary bio-behavioral research project builds upon two national probability-based surveys of reproductive and sexual health in emerging adults (18-25) carried out in 2005 and 2010. The project has two aims: (1) to describe and analyze the current prevalence of risky sexual behaviors, as well as its dynamics in the 2005-2020 period using repeated cross-sectional data; and (2) to provide a systematic assessment of the role of personal faith and religiosity in emerging adults’ sexual and reproductive health. The second aim is related to growing levels of religiosity among young people and the absence of comprehensive school-based sexuality education in Croatia.To collect data, we intend to use a national online panel of 1,200 individuals aged 18-25 years maintained by a local market research firm. All study procedures in the behavioral arm are specified according to the total survey error model. The biological arm of the study will include 400 urine samples to be tested for Chlamydia trachomatis (as in the 2010 study) from randomly sampled participants in the behavioral survey. Informed consent will be asked separately for the behavioral and biological parts of the study. Urine samples will be tested for Chlamydia trachomatis using PCR. All samples will be coded with a unique random-digit code to enable linking with behavioral data. Participants will receive a card containing a code and a phone number to learn about their result, receive post-test counseling and, if needed, be referred for treatment.The project will provide detailed and systematic insight into the dynamics of reproductive and sexual health in emerging adults to be used for evidence-based policy planning and specific public health interventions. In addition, our testing of four specific conceptual mechanisms hypothesized to underlie the association between religiosity and sexual risk taking is an original contribution to the literature currently characterized by ambivalent findings.]]></summary_en></project><project>
<id>9378</id><title_hr><![CDATA[Biodostupnost karotenoida kukuruza kod nesilica: utjecaj mikrostrukture zrna i sastava smjese]]></title_hr><title_en><![CDATA[]]></title_en><user_id>21438</user_id><user_firstLast_name>Kristina Kljak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-5718</code><acronim><![CDATA[ColourMaize]]></acronim><duration>14.09.2020 - 14.09.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Agronomski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Agriculture]]></institution_en><team_members_id>855936</team_members_id><team_members_names><![CDATA[ Doktorand: Dora Zurak ]]></team_members_names><keywords_hr><![CDATA[karotenoidi, zrno kukuruza, hibridi kukuruza, bioraspoloživost, biodostupnost, nesilice, žumanjak jajeta, fizikalno-kemijska svojstva, sastav smjese]]></keywords_hr><keywords_en><![CDATA[carotenoids, maize grain, maize hybrids, bioaccessibility, bioavailability, laying hens, egg yolk, physicochemical traits, diet composition]]></keywords_en><summary_hr><![CDATA[Žumanjak jajeta se smatra bogatim izvorom žutih pigmenata luteina i zeaksantina, spojeva iz skupine karotenoida važnih za zdravlje očiju i antioksidacijsku zaštitu ljudskog organizma. Karotenoidi jajeta potječu samo iz hrane jer ih kokoši nesilice ne mogu sintetizirati. Zrno kukuruza je jedina žitarica koja sadrži značajne količine karotenoida, među kojima najviše ljudima potrebnih luteina i zeaksantina. Zbog visokog udjela zrna u hrani nesilica, oni mogu ne samo doprinijeti već i biti jedini izvor pigmenata za poželjnu boju žumanjka jajeta. Međutim, sadržaj i vjerojatno iskoristivost karotenoida su određeni genotipom kukuruza. Generalno, sva prisutna količina karotenoida hrane nije bioraspoloživa jer se iz matrice hrane samo dio oslobodi tijekom probave te je dostupan za apsorpciju, metabolizam i ugradnju u jaja (biodostupnost). Matrice potpune hrane nesilica i zrna su dva glavna čimbenika koji utječu na bioraspoloživost i biodostupnost karotenoida iz zrna kukuruza. Obilježja zrna kukuruza povezana s mikrostrukturom endosperma su kao i sadržaj karotenoida genetski uvjetovani te će se predloženim istraživanjem povezati bioraspoloživost karotenoida određena in vitro metodama te biodostupnost određena u pokusu s nesilicama i fizikalno-kemijska obilježja zrna najzastupljenijih hibrida kukuruza u RH. Zatim će se utjecaj obrade zrna – temperatura sušenja nakon berbe i veličina čestice meljave, i promjene sastava potpunih krmnih smjesa – različite razine dodatka repičinog ulja, lecitina i vitamina A te forme dodatka mikrominerala na biodostupnost karotenoida odrediti u tri hranidbena pokusa s nesilicama hranjenih smjesama s dva hibrida kukuruza divergentne biorasploživosti određene u prethodnom pokusu. Bioraspoloživost i biodostupnost karotenoida iz zrna kukuruza do sada nisu istraživane te bi poznavanje čimbenika koji na njih utječu omogućilo njihovo bolje iskorištenje u pigmentaciji peradi te odabir i proizvodnju hibrida boljih pigmentacijskih svojstava.]]></summary_hr><summary_en><![CDATA[Egg yolk is considered a rich source of yellow pigments lutein and zeaxanthin, carotenoid compounds important for eye health and antioxidant protection of the human body. Egg carotenoids are from dietary intake since laying hens can not synthesize them. Maize grain is the only cereal with significant content of carotenoids, mostly for humans important lutein and zeaxanthin. Due to the high proportion of grain in hens diet, they can contribute, but also be the only source of pigments for desirable egg yolk colour. However, the content and likely utilization of carotenoids are determined by maize genotype. Generally, all present carotenoid amounts in the diet are not bioaccessible as only a fraction is released from matrix during digestion and is available for absorption, metabolism and egg deposition (bioavailability). Matrices of laying hens diet and grain are two main factors affecting bioaccessibility and bioavailability of maize carotenoids. Maize grain traits associated with the endosperm microstructure are, as well as the carotenoid content, genetically determined, and proposed research will relate bioaccessibility of carotenoids determined using in vitro methods and bioavailability determined in hen trials with physicochemical traits of the most common maize hybrids in Croatia. Then, the effect of grain processing – the drying temperature and the grinding particle size, and changes in the diet composition – different supplementation levels of rapeseed oil, lecithin, and vitamin A, and micromineral form, on in vivo bioavailability of maize carotenoids will be investigated in three trials with hens fed diets based on two hybrids of diverse bioavailability selected in previous trial. Bioaccessibility and bioavailability of maize grain carotenoids have not been studied so far, and knowing the factors influencing them will allow better utilization of carotenoids for poultry pigmentation and the selection and production of hybrids of higher pigmentation properties.]]></summary_en></project><project>
<id>9380</id><title_hr><![CDATA[Lingvistička geografija Hrvatske u europskome okružju]]></title_hr><title_en><![CDATA[]]></title_en><user_id>589</user_id><user_firstLast_name>Nikola Vuletić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-4840</code><acronim><![CDATA[LinGeH]]></acronim><duration>01.10.2020 - 31.01.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filologija, </scie_field_hr><scie_field_en>Philology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zadru]]></institution_hr><institution_en><![CDATA[University of Zadar]]></institution_en><team_members_id>856145</team_members_id><team_members_names><![CDATA[ Doktorand: Hrvoje Bazina ]]></team_members_names><keywords_hr><![CDATA[lingvistička geografija, hrvatska dijalektologija, arealna lingvistika, geolingvistika, Lingvistički atlas Istre, OLA, ALE, ALM]]></keywords_hr><keywords_en><![CDATA[linguistic geography, Croatian dialectology, linguistic atlas, geolinguistics, Linguistic atlas of Istria, OLA, ALE, ALM]]></keywords_en><summary_hr><![CDATA[Temeljni je cilj projekta stvaranje reprezentativnoga jezičnog zemljovida Hrvatske (oko 150 pomno odabranih hrvatskih punktova te desetak punktova hrvatskih govora iz dijaspore) te izradba oglednih digitalnih zemljovida za Lingvistički atlas Istre na temelju kartografske obradbe tridesetak reprezentativnih tema. Tako zahtjevan i složen zadatak može se ostvariti samo stvaranjem snažne istraživačke grupe na području lingvističke geografije kako bi se koordinirala geolingvistička i dijalektološka istraživanja koja se provode u raznim istraživačkim ustanovama u Hrvatskoj. Objedinjavanjem istraživanja oko jednog središnjeg geolingvističkog znanstvenog projekta postići će se sinergijski učinak s ciljem stvaranja reprezentativnog jezičnog zemljovida Hrvatske. Rad na projektu provodit će se suradnjom nekoliko istraživačkih skupina (Zavod za lingvistička istraživanja HAZU, Sveučilišta u Zagrebu, Zadru, Rijeci i Puli, IHJJ) te dvoje suradnika iz Nizozemske i Slovenije. Iako se ovaj projektni prijedlog temelji na tradicionalnim dijalektološkim istraživanjima i uvriježenoj metodologiji lingvističke geografije, u izvedbi će se primjenjivati suvremene metode i tehnike na polju lingvističke geografije, odnosno arealne lingvistike. Jezični će zemljovidi biti georeferencirani, podatci će biti pohranjeni u baze podataka, a samo kartografiranje izvodit će se s pomoću GIS-a. Interpretacija zemljovida koja će se temeljiti na analizi unutarjezičnih i izvanjezičnih čimbenika rasprostranjenosti analizirane jezične pojave predstavlja bitan odmak od tradicionalne lingvističke geografije. Konačno, ovaj je projekt i međunarodno relevantan jer će pojedini suradnici hrvatsku jezičnu građu prezentirati i u okvirima već postojećih europskih projekata lingvističke geografije (Općeslavenski lingvistički atlas – OLA, Europski lingvistički atlas – ALE i Mediteranski lingvistički atlas – ALM) što neprijeporno bitno pridonosi međunarodnoj vidljivosti hrvatske dijalektologije i jezikoslovlja uopće.]]></summary_hr><summary_en><![CDATA[The basic goal of the project is to create a representative language map of Croatia (about 150 carefully selected Croatian points and about ten Croatian points from the diaspora). The second task is to design digital maps for the Linguistic Atlas of Istria based on the cartographic processing of thirty representative themes. Such a demanding and complex task can only be achieved by the creation of a strong research group in the field of linguistic geography in order to coordinate the geolinguistic and dialectological research carried out in various research institutes throughout Croatia. The project will bring together several research groups (at the Linguistic Research Institute of the Croatian Academy, Universities of Zagreb, Zadar, Rijeka and Pula, IHJJ) and two international associates. Consolidating their research into one central geolinguistic research project will offer synergistic benefits and will enable the creation of a representative language map of Croatia. Although this project proposal is based on traditional dialectological research and the established methodology of linguistic geography, contemporary methods and techniques will be applied in the field of linguistic geography. The language maps will be georeferenced, the data will be stored in the database, and mapping will be done using GIS. The essential innovation from traditional linguistic geography is the interpretation of the maps based on an analysis of the internal and external factors that influenced the distribution of linguistic phenomena. Finally, this project is internationally relevant, as some of the associates will present the Croatian language material within the framework of already existing European linguistic projects, such as Slavic Linguistic Atlas – OLA, European Linguistic Atlas – ALE and Mediterranean Linguistic Atlas – ALM. This undoubtedly contributes significantly to the international visibility of Croatian dialectology and linguistics in general.]]></summary_en></project><project>
<id>9381</id><title_hr><![CDATA[Vitalitet obične bukve (Fagus sylvatica L.) u izmijenjenim klimatskim uvjetima]]></title_hr><title_en><![CDATA[]]></title_en><user_id>848</user_id><user_firstLast_name>Nenad Potočić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-3052</code><acronim><![CDATA[VitaClim]]></acronim><duration>14.09.2020 - 13.12.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Šumarstvo, </scie_field_hr><scie_field_en>Forestry, </scie_field_en><institution_hr><![CDATA[Hrvatski šumarski institut]]></institution_hr><institution_en><![CDATA[Croatian Forest Research Institute]]></institution_en><team_members_id>861738</team_members_id><team_members_names><![CDATA[ Doktorand: Mia Marušić ]]></team_members_names><keywords_hr><![CDATA[defolijacija, prirast, ishrana bilja, fotosinteza, modeliranje, rasadnički pokus]]></keywords_hr><keywords_en><![CDATA[defoliation, increment, foliar nutrition, photosynthesis, modelling, nursery trial]]></keywords_en><summary_hr><![CDATA[Vitalitet ili stanje stabla možemo definirati kao sposobnost stabla da asimilira, preživi stres i reagira na promjenu okolišnih uvjeta. Promijenjeni klimatski uvjeti smatraju se kritičnim za stanje stabala, jer određuju dostupnost vode u smislu njezine apsorpcije i transporta u drveću, a nedostatak vode uzrokuje nedostatnu ishranu biljaka i posljedični gubitak vitaliteta. Osnovni cilj ovog projekta je istražiti utjecaj promijenjenih klimatskih uvjeta na različite indikatore vitaliteta drveća, kao i njihove moguće međuovisnosti.Koristit ćemo nacionalne i europske podatke o osutosti obične bukve iz baze podataka ICP Forests programa i upotpuniti ih uzorkovanjem lišća, tla i izvrtaka stabala bukve na ICP Forests plohama razine I u Hrvatskoj. Povijesni klimatski podaci i projekcije klime biti će korišteni za daljnje analize. Modelirati ćemo promjene osutosti kroz vrijeme i prostor i odrediti utjecaj klimatskih uvjeta na osutost bukve ujedno ispitujući prikladnost pojedinih statističkih metoda. Istražit ćemo utjecaj klimatskih uvjeta na ishranu bukve biogenim makroelementima i odrediti da li se njihove koncentracije razlikuju u odnosu na osutost stabala. Naš je cilj također utvrditi postoje li povezanosti osutosti i debljinskog prirasta, uključujući mogući efekt kašnjenja. Konačno, fiziologija stresa obične bukve biti će istražena u kontroliranim uvjetima analizirajući fotosintezu, rast i ishranu sadnica u uvjetima sušnog stresa i za vrijeme oporavka od suše, upotpunjujući naša planirana istraživanja u bukovim sastojinama.Rezultati ovog projekta osigurati će podlogu za različite procese odlučivanja vezane uz gospodarenje šumama, usluge šumskih ekosustava, izvješćivanje o stanju šuma kao i planiranje u svrhu smanjenja posljedica klimatskih promjena. ]]></summary_hr><summary_en><![CDATA[Tree vitality or condition can be defined as the ability of a tree to assimilate, to survive stress and to react to changing conditions. Changing climate properties can be critical for the condition of trees, as they can bring about the disturbed water absorption and transport, and water deficits may cause inadequate nutrition of trees with a subsequent loss of tree vitality. The main goal of this project is to explore the impact of changing climate conditions on various indicators of tree vitality, as well as their possible interrelations.We will use national and Europe-wide data of common beech defoliation from ICP Forests program and complete this data by sampling foliage, soil and increment cores of common beech trees on Croatian ICP Forests Level I plots. Past climate data and climate projections will be used in the subsequent analysis.We aim to model temporal and spatial change of defoliation and determine the influence of climate conditions on common beech defoliation, thereby also testing the suitability of various statistical methods. Furthermore, our objectives are to investigate the influence of climate conditions on foliar mineral nutrition of common beech and determine whether foliar element concentrations differ according to defoliation. We will also establish the relationships between defoliation and radial growth as well as investigate whether defoliation has a lagged effect on radial growth. Finally, the stress physiology of beech will be investigated in a controlled environment by analyzing photosynthesis, growth and nutrition of potted plants under drought stress and during post-drought recovery, complementing the results of the mentioned exploratory research.We expect the results of this project to provide basis for various decision-making processes related to forest management, forest ecosystem services, forest status reporting and climate mitigation planning. ]]></summary_en></project><project>
<id>9382</id><title_hr><![CDATA[Redukcija vibracija u mehaničkim sustavima]]></title_hr><title_en><![CDATA[]]></title_en><user_id>844</user_id><user_firstLast_name>Zoran Tomljanović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-2659</code><acronim><![CDATA[VIMS]]></acronim><duration>01.09.2020 - 01.09.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Fakultet primijenjene matematike i informatike]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, School of Applied Mathematics and Informatics]]></institution_en><team_members_id>855851</team_members_id><team_members_names><![CDATA[ Doktorand: Marinela Pilj Vidaković ]]></team_members_names><keywords_hr><![CDATA[mehanički sustav,  redukcija vibracija, kvadratni svojstveni problem, izolacija frekvencija, model reduciranog reda, optimizacija parametara]]></keywords_hr><keywords_en><![CDATA[mechanical system, vibration reduction, quadratic eigenvalue problem, frequency isolation, reduced-order model, parameter optimization]]></keywords_en><summary_hr><![CDATA[Analiza i redukcija vibracija u mehaničkom sustavu istaknuti su problemi u brojnim istraživačkim poljima. Iako je analiza vibracija sustava tema koja je intenzivno proučavana u skorijim desetljećima, mnogi problemi su i dalje otvoreni. Slučaj kada nema vanjskog podražaja vodi do proučavanja homogenih sustava, a s druge strane postojanje vanjske sile vodi do proučavanja nehomogenog sustava. U ovisnosti o prisustvu vanjske sile i primjenama, mi ćemo proučavati četiri istraživačke teme.Unutar prve teme proučavat ćemo teorijske rezultate relevantne za redukciju vibracija u mehaničkim sustavima.  Planiramo razviti teorijske rezultate koji karakteriziraju važna svojstva kvadratnog svojstvenog problema (QEP) koji se pojavljuje u analizi titranja mehaničkih sustava. Unutar druge istraživačke teme razvit ćemo nove metode za izolaciju frekvencija i pri tome koristit ćemo metode bazirane na algoritmima za ne-glatku optimizaciju. U ovom slučaju razvit ćemo nove algoritme koji čuvaju strukturu matrica kao i svojstva promatranog svojstvenog problema. U trećoj istraživačkoj temi promatrat ćemo redukciju vibracija baziranu na novim kriterijima koji koriste norme sustava (npr. H2 i Hinf) za sustav sa više ulaza i više izlaza. Također, proučavat ćemo pristupe za aproksimaciju modela punog reda modelom reduciranog reda koji zadržava strukturu parametarske ovisnosti. Novi pristupi će biti dobro prilagođeni za efikasnu optimizaciju parametara i proučavanje važnih svojstava sustava. U četvrtoj istraživačkoj temi proučavat ćemo integraciju istraživačkih tema I-III i primjenu u stvarnim primjerima. Nadalje, primjenit ćemo nove pristupe i algoritme u različitim akademskim primjerima, ali također i u stvarnim primjerima iz života koji se pojavljuju, npr. u auto industriji (poput problema kočionog diska), građevinskim konstrukcijama (poput greda i građevina), itd. Stoga, rezultati iz ovog projekta mogli bi imati široku primjenu.]]></summary_hr><summary_en><![CDATA[Vibration analysis and vibration reduction for mechanical systems are prominent problems in numerous research fields. Although the vibrations analysis is an intensively studied topic in recent decades, many problems still remain open. While the case without external excitation leads to the study of homogeneous systems, presence of an external forcing leads to the study of  nonhomogeneous systems. Depending on the presence of an external excitation and applications, we will consider four different research themes. Within the first research theme, we will study theoretical results that are relevant for vibration reduction. We plan to develop theoretical results that characterize important properties of the quadratic eigenvalue problem (QEP) arising from vibration analysis of mechanical systems. Within the second research theme we will develop new methods for frequency isolation and utilize methods which are based on algorithms for non-smooth optimization. For this case we will derive new algorithms that preserve the structure of the matrices and structural properties of the considered QEP. In the third research theme, we will consider vibration reduction based on criteria that use system norms (e.g. H2 and Hinf) for Multiple-Input Multiple-Output case. We will also study approaches for approximating the full-order model with a reduced-order model that retains the structure of parametric dependence. The new approaches will be well suited for computationally efficient parameter optimization and the study of important system properties. In the fourth research theme we will consider integrating research themes I-III and applications in real world examples. Moreover, we will apply obtained new approaches and algorithms in various academic examples, but also in real life examples that arise, e.g., in car industry (such as disc brake problem) and civil engineering (such as beams, civil buildings), etc.  Therefore, the results from this project could have wide applications.]]></summary_en></project><project>
<id>9383</id><title_hr><![CDATA[Razvoj metodologije procjene podložnosti na klizanje za planiranje namjene zemljišta primjenom LiDAR tehnologije]]></title_hr><title_en><![CDATA[]]></title_en><user_id>27065</user_id><user_firstLast_name>Snježana Mihalić Arbanas</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-2432</code><acronim><![CDATA[LandSlidePlan]]></acronim><duration>26.10.2020 - 25.02.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Rudarstvo, nafta i geološko inženjerstvo, </scie_field_hr><scie_field_en>Mining, petroleum and geological engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Rudarsko-geološko-naftni fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mining, Geology and Petroleum Engineering]]></institution_en><team_members_id>858322</team_members_id><team_members_names><![CDATA[ Doktorand: Marko Sinčić ]]></team_members_names><keywords_hr><![CDATA[klizišta, LiDAR, inventar klizišta, procjena podložnosti na klizanje, prostorno planiranje, namjena zemljišta, geohazard]]></keywords_hr><keywords_en><![CDATA[landslides, LiDAR, landslide inventory, landslide susceptibility assessment, spatial planning, land use, geohazard]]></keywords_en><summary_hr><![CDATA[Misija LandSlidePlan projekta je stjecanje novih znanja nužnih za procjenu podložnosti na klizanje u svim dijelovima Hrvatske, sa svrhom izrade karata podložnosti koje će biti korištene u procesu planiranja namjene zemljišta. Specifični ciljevi projekta su: (1) izraditi optimalni digitalni model terena bez vegetacije koji odražava morfologiju klizišta, te održava razliku između dijelova terena zahvaćenih klizanjem i dijelova terena bez klizišta; (2) izraditi pouzdanu kartu podložnosti na klizanje s najboljim prikazom područja podložnih na klizanje i područja s niskom vjerojatnosti pojave klizišta primjenom znanstvenih metoda na reprezentativnim područjima u Hrvatskoj, sa specifičnim inženjerskogeološkim uvjetima koji uvjetuju pojavu klizišta; (3) izraditi karte koje prikazuju informacije o klizištima prema potrebama sustava prostornog uređenja u Hrvatskoj, a obuhvaćaju lokalnu i regionalnu razinu te su usklađene na nacionalnoj razini. Znanstvena istraživanja će se temeljiti na inovativnim tehnologijama opažanja Zemlje, GIS analizama, statističkim metodama procjene podložnosti na klizanje, te će uzeti u obzir postojeća ograničenja koja se odnose na dostupnost prostornih podatka u Hrvatskoj te na potrebu za cjelovitim praktičnim rješenjima sustava prostornog planiranja Republike Hrvatske, sukladno s globalnim i europskim zahtjevima o održivom razvoju te zaštiti ljudi i okoliša. Zbog različitih prirodnih okoliša i tipova korištenja zemljišta u različitim dijelovima Hrvatske, metodologija će biti razvijena za tri pilot područja, odabrana na temelju karakteristične geološke građe i stupnja urbanizacije, u podsljemenskoj zoni Grada Zagreba, Hrvatskom Zagorju i Istri. Glavni rezultat primijenjenog istraživanja LandSlidePlan projekta je razvoj metodologije za procjenu podložnosti na klizanje korištenjem LiDAR tehnologije kao i izrada smjernica za praktičnu primjenu razvijene metodologije za sustavnu izradu karata klizišta kao dokumenata o ograničenjima u prostoru. ]]></summary_hr><summary_en><![CDATA[Mission of the LandSlidePlan project is to gain a new knowledge necessary for landslide susceptibility assessment in all parts of Croatia, with the objective of preparation of maps that will be used in the process of land use planning. Specific objectives of the project are: (1) to create optimal digital bare-earth model which reflects landslide morphology, and displays differences between landslide and non-landslide area; (2) to create reliable landslide susceptibility map with the appropriate presentation of spatial probability of landslide occurrence, by use of scientific methods on representative areas in Croatia, with specific engineering geological conditions; (3) to create maps which display information about landslides according to needs of the system of spatial planning in Croatia, including local and regional government and are homogenized at the national level. Scientific investigations will be based on innovative technologies of Earth Observations, GIS analyses and statistical methods of landslide susceptibility assessment considering existing limitation related to availability of spatial data in Croatia. Moreover, it is necessary to take into account needs for comprehensive practical solutions for the system of spatial planning in Croatia, in line with global and European requirements related to sustainable development, civil protection and environment. Because of variety of natural environments and types of land use in different parts of Croatia, methodology will be developed for 3 pilot areas, selected on the basis of characteristic geological settings and urbanization stage, in Podsljeme Zone in Zagreb, Hrvatsko Zagorje and Istria. The main results of the applied research of the project is methodology development for landslide susceptibility assessment using LiDAR technology as well as development of guidelines for practical application of the developed methodology for systematic production of landslide maps as documents about limitation in space.]]></summary_en></project><project>
<id>9384</id><title_hr><![CDATA[Procjena stanja i obnova postojećih građevina -  Razvoj suvremenih metoda za zidane i drvene konstrukcije]]></title_hr><title_en><![CDATA[]]></title_en><user_id>19909</user_id><user_firstLast_name>Mislav Stepinac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-9251</code><acronim><![CDATA[ARES]]></acronim><duration>01.12.2020 - 30.04.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Građevinarstvo, </scie_field_hr><scie_field_en>Civil engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Građevinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Civil Engineering]]></institution_en><team_members_id>861469</team_members_id><team_members_names><![CDATA[ Doktorand: Karlo Ožić ]]></team_members_names><keywords_hr><![CDATA[ocjena, ziđe, drvo, pouzdanost, obnova, konstrukcije, metode]]></keywords_hr><keywords_en><![CDATA[assessment, masonry, timber, reliabilty, rehabilitation, structures, methods]]></keywords_en><summary_hr><![CDATA[Više od 75% hrvatskog građevinskog fonda starije je od 30 godina, što predstavlja vrijeme kod kojeg je, za većinu objekata, potrebna renovacija ili rekonstrukcija. Više od 40% zgrada starije je od 50 godina što bi značilo da je uporabni vijek tih zgrada već istekao. Procjena stanja postojećih konstrukcija temelji se na identifikaciji, lokalizaciji i ocjeni propadanja i oštećenja konstrukcije. Nalazi procjene stanja temeljeni su na postupcima projektiranja novih konstrukcija i planiranje zahvata obično sugerira pojačanje konstrukcije. Trenutna praksa ne može se smatrati prikladnom za sigurnu odluku o pouzdanosti konstrukcije. Determinističke metode za vrjednovanje postojećih konstrukcija dopuštaju jednostavnu procjenu, ali pate od velikih faktora sigurnosti. Kod procjene stanja na razini pouzdanosti izbjegava se otkazivanje i nepotrebno rušenje konstrukcije, a rezultat su sigurnije konstrukcije i bolje korištenje resursa. Rješavanjem problema kao što je učinkovito određivanje svojstava konstrukcije i materijala, određivanje utjecaja opterećenja u proteklom vremenu te njegovog trajanja na ponašanje konstrukcije može biti vrijedno i od velike pomoći za projektante, kao i za istraživače i znanstvenike koji se bave procjenom stanja zidanih i drvenih konstrukcija. Cilj ovog istraživačkog projekta je istražiti ulogu procjene stanja na analizu pouzdanosti postojećih konstrukcija. Projekt će se baviti postojećim zidanim i drvenim konstrukcijama kako bi utvrdio prednosti procjene stanja u pogledu ekonomičnosti i sigurnosti konstrukcija. U projektu će se vrjednovati metode “nadogradnje” podataka za primjenu procjene stanja te će se proučavati ponašanje konstrukcija ovisno o vremenu i utjecajima uvjeta okoliša. Izradit će se smjernice s integriranim metodama pouzdanosti za projektiranje, procjenu i obnovu stanja postojećih konstrukcija te će one biti najznačajniji rezultat projekta. Rezultati projekta imat će značajan utjecaj na međunarodne norme za projektiranje konstrukcija.]]></summary_hr><summary_en><![CDATA[More than 75% of the building stock in Croatia is older than 30 years, an age often requiring renovation or modification of buildings. In addition, more than 40% of the building stock is older than 50 years meaning that the service life of the structures is expired. The assessment of existing structures focuses mainly on the identification, localization and evaluation of deterioration, decay and damage. The diagnoses are based on the design procedures of new structures and the planning of interventions. The current practice might not be considered suitable to facilitate confident decisions about the reliability of structures. Deterministic methods for the evaluation of existing structures allow for an easy evaluation but suffer from large safety factors. Reliably assessing structures avoids failures and unnecessary decommissioning, and leads to safer structures and better use of resources. Solving the issues like the determination of structural & material properties, quantification of the impact of loading history and load duration on structural performance can be valuable and precious help for designers as well as for researchers and scholars dealing with the assessment of masonry and timber structures. The aim of this research project is to study the role of assessment on the reliability analysis of existing structures. The project focuses on existing masonry and timber structures to evaluate the benefits of assessment with regard to the economy and safety of structures. Also, the project will evaluate updating methods for the application of the assessment & verification of structures and consideration of time-dependent behaviour & the influence of environmental conditions. Design guidelines and integration of reliability methods in assessment and rehabilitation of existing structures will be the main benefit of the project. The results of the project will have a decisive impact on international codes regarding structural engineering.]]></summary_en></project><project>
<id>9385</id><title_hr><![CDATA[Algoritmi dubokog podržanog učenja za upravljanje rizicima]]></title_hr><title_en><![CDATA[]]></title_en><user_id>13406</user_id><user_firstLast_name>Zvonko Kostanjčar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-5878</code><acronim><![CDATA[DREAM]]></acronim><duration>12.01.2021 - 11.07.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>864841</team_members_id><team_members_names><![CDATA[ Doktorand: Tessa Bauman Bauman ]]></team_members_names><keywords_hr><![CDATA[duboko podržano učenje, kvantitativno upravljanje rizicima, duboko učenje reprezentacija, računalne financije, optimizacija portfelja]]></keywords_hr><keywords_en><![CDATA[deep reinforcement learning, quantitative risk management, deep representation learning, computational finance, portfolio optimization]]></keywords_en><summary_hr><![CDATA[Potreba za upravljanjem neizvjesnošću ishoda u procesima donošenja odluka dovela je do razvoja područja upravljanja rizicima. Tehnološki napreci i rastuća dostupnost podataka potaknuli su korištenje statističkih pristupa i kvantitativnog upravljanja rizicima u mnogim područjima, poput aktuarskih procjena, kreditnog rizika i optimizacije portfelja. Međutim, važan aspekt upravljanja rizicima – intrinzično sekvencijalna priroda problema – je zanemaren jer tradicionalne statističke metode razmatraju samo rizik jedne izolirane akcije bez uzimanja u obzir utjecaja nizova akcija na dugoročne rizike. U međuvremenu, evolucija računalne snage omogućila je uspješno korištenje složenih pristupa strojnog učenja, uključujući duboke arhitekture, u stvarnim problemima. U ovom projektnom prijedlogu, motivirani zahtjevima suvremenih scenarija upravljanja rizicima, fokusiramo se na pristup zasnovan na podržanom učenju, uzimajući u obzir neizvjesnosti budućih ishoda kao izvor rizika u problemu izravnog adaptivnog upravljanja gdje model razmatranog sustava nije potpuno poznat. Opći cilj ovog projekta je razviti novu klasu algoritama podržanog učenja osjetljivih na rizik za dinamičke okoline s primjenama u upravljanju financijskim rizicima. Konkretno, unutar predloženog projekta planiramo: (i) uključiti cilj osjetljiv na rizik u algoritme podržanog učenja temeljene na politici (ii) razviti novu klasu algoritama podržanog učenja temeljenu na aproksimaciji funkcija vrijednosti s eksplicitnim modeliranjem rizika uključenog u donošenje odluka agenta; (iii) implementirati modele reprezentacije prostora stanja koji izvlače korisne informacije iz podataka vremenskih nizova korištenjem latentnih modela; i (iv) oblikovati i implementirati metode optimizacije portfelja na temelju predloženih algoritama. Novo razvijeni algoritmi podržanog učenja poboljšat će postojeće metode i omogućiti principijelniji pristup u procesima donošenja odluka u neizvjesnim okolnostima.]]></summary_hr><summary_en><![CDATA[The need to manage uncertainty of outcomes in decision-making has given rise to the field of risk management. Advances in technology and rising availability of data have motivated the use of statistical approaches and quantitative risk management in many areas, such as actuarial assessments, credit risk, or portfolio optimization. However, an important aspect of risk management – its intrinsically sequential nature – is neglected by traditional statistical methods which only consider the risk of a single isolated action without taking into consideration the effect of sequences of actions on long-term risks. Meanwhile, the evolution of computational power has enabled the successful employment of complex machine learning approaches, including deep architectures, to real-world problems. In this project proposal, motivated by the requirements of modern risk management scenarios, we focus on a reinforcement learning based approach, by regarding the uncertainties of future outcomes as sources of risk in a direct adaptive control problem where the model of the considered system is not completely known. The overall goal of this project is to develop a novel class of risk-sensitive reinforcement learning algorithms in dynamic environments with applications in financial risk management. Specifically, within the proposed project we plan to: (1) incorporate a risk-sensitive objective in policy based reinforcement learning algorithms; (2) develop a new class of reinforcement learning algorithms based on value function approximation with explicit modeling of risk involved in agent decision making; (3) implement state space representation models that extract useful information from time series data by exploiting latent models; and (4) design and implement portfolio optimization methods based on proposed algorithms. The newly developed algorithms will ameliorate the typical flaws of the existing methods and enable decision makers to pursue a more principled approach to uncertainty.]]></summary_en></project><project>
<id>9386</id><title_hr><![CDATA[The Integrated Initiative of European Laser Research Infrastructures — LASERLAB-EUROPE i Centar za napredne laserske tehnike - CALT]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5410</user_id><user_firstLast_name>Ticijana Ban</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-7060</code><acronim><![CDATA[]]></acronim><duration>24.09.2020 - 23.03.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut za fiziku]]></institution_hr><institution_en><![CDATA[Institute of Physics in Zagreb]]></institution_en><team_members_id>856067</team_members_id><team_members_names><![CDATA[ Doktorand: Ivana Puljić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>9389</id><title_hr><![CDATA[Science-based RISK GOvernance of Nano-tEchnology – RiskGONE]]></title_hr><title_en><![CDATA[]]></title_en><user_id>573</user_id><user_firstLast_name>Ivana Vinković Vrček</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-9355</code><acronim><![CDATA[]]></acronim><duration>01.10.2020 - 30.09.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Interdisciplinarne prirodne znanosti, </scie_field_hr><scie_field_en>Interdisciplinary natural sciences, </scie_field_en><institution_hr><![CDATA[Institut za medicinska istraživanja i medicinu rada]]></institution_hr><institution_en><![CDATA[Institute for Medical Research and Occupational Health]]></institution_en><team_members_id>861725</team_members_id><team_members_names><![CDATA[ Doktorand: Lucija Božičević ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>9391</id><title_hr><![CDATA[Profesionalizam u zdravstvu: odlučivanje u praksi i znanosti]]></title_hr><title_en><![CDATA[]]></title_en><user_id>776</user_id><user_firstLast_name>Ana Marušić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-3390</code><acronim><![CDATA[ProDeM]]></acronim><duration>01.10.2020 - 01.10.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Javno zdravstvo i zdravstvena zaštita, </scie_field_hr><scie_field_en>Public health and health services, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Split School of Medicine]]></institution_en><team_members_id>861720</team_members_id><team_members_names><![CDATA[ Doktorand: Jakov Matas ]]></team_members_names><keywords_hr><![CDATA[istraživanje u zdravstvu, zdravstvena praksa, odlučivanje, medicina utemeljena na dokazima, istraživačka odgovornost, znanstvena evaluacija]]></keywords_hr><keywords_en><![CDATA[health research, health practice, decision making, evidence-based medicine, research integrity, research evaluation]]></keywords_en><summary_hr><![CDATA[Predloženi projekt nastavlja istraživanja profesionalizma u zdravstvu iz prethodnog HRZZ projekta. U ovom se projektu usredotočujemo na odlučivanje kao važan čimbenik u zdravstvenoj skrbi i znanosti. Prva istraživačka tema usmjerena je na to kako pacijenti, studenti i zdravstveni stručnjaci donose odluke u praksi, utemeljene na tekstualnim sažetcima sinteze dokaza u Cochraneovim sustavnim pregledima zdravstvenih intervencija. Temeljem nalaza iz tog dijela istraživanja, testirat ćemo intervencije za poboljšanje odlučivanja u praksi. Intervencije će uključivati smjernice za kliničku praksu i mrežni alat. Druga istraživačka tema usmjerena je na donošenje odluka u istraživanju u zdravstvu u širem kontekstu znanstvene evaluacije. Istražit ćemo čimbenike koji utječu na odlučivanje o znanstvenoj čestitosti, analizom organizacijske etičke klime na medicinskom fakultetu u usporedbi s drugim fakultetima i testiranjem intervencija za poticanje razumijevanja etičkih pitanja. Kvalitativno i kvantitativno ćemo istražiti proces donošenja odluka o kvaliteti znanstvenog istraživanja u zdravstvu proučavanjem postupka evaluacije znanstvenih projekata i članaka u časopisima. U tom dijelu projekta radit ćemo s podatcima koje smo dobili od znanstvenih izdavača i agencija za financiranje znanosti. Pristup svakom specifičnom cilju istraživanja bit će utemeljen na trenutnom znanju i identifikaciji relevantnih istraživačkih pitanja; na uporabi adekvatnih istraživačkih ustroja i inovativnih metodologija, uključujući strojno učenje i računalnu jezičnu analizu; na sintezi rezultata u eksplanatorne teorije i modele; i na razvoju oruđa i diseminaciju rezultata važnih za javnu politiku i pristup zdravstvenoj skrbi. Bolje razumijevanje donošenja odluka u zdravstvenoj praksi i znanosti donijet će nove spoznaje i oruđa za poboljšanje zdravstvene skrbi i donijeti važne ekonomske i javnozdravstvene koristi.]]></summary_hr><summary_en><![CDATA[The proposed project aims to continue the research on professionalism in health from the previous CSF project. In this proposal, we focus on decision making as an important aspect of health care and research. The first research theme addresses decision making in health care practice. We will investigate the determinants of decision making by patients, students and health professionals in relation to textual summaries of evidence synthesis in Cochrane systematic reviews of health interventions. Based on the findings from this research, we will test interventions to improve making decisions in health. The interventions will include health practice guidelines and a web-based tool. The second research theme addresses decision making in health research within the wider context of research evaluation. We will explore factors that contribute to decision making about integrity in research, by analysing the ethical climate at a medical school compared to other university schools and by testing interventions to increase awareness about ethics issues. We will also study the process of decisions about quality of health research by qualitative and quantitative analysis of the peer evaluation of research grant proposals and of journal articles. This part of research will use dataset that were made available to us by granting bodies and journals. Each specific objective of the proposed research will be based on current evidence and identified knowledge gaps; it will use appropriate research design and innovative methodological tools, including machine learning and deep language analysis; it will synthesise research results into explanatory theories and models; and it will develop tools and disseminate results and experience relevant for policy and public use. Better understanding of how decisions are made in health practice and research will provide evidence and new tools to inform improving health care and bring important economic and public health benefits.]]></summary_en></project><project>
<id>9393</id><title_hr><![CDATA[Biougljen kao ekološki prihvatljiv i održiv način upravljanja ishranom vinove loze u kontekstu klimatskih promjena]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3037</user_id><user_firstLast_name>Igor Palčić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-3145</code><acronim><![CDATA[BIONUTRIVINE]]></acronim><duration>01.09.2020 - 31.08.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Institut za poljoprivredu i turizam]]></institution_hr><institution_en><![CDATA[Institute of Agriculture and Tourism in Poreč]]></institution_en><team_members_id>855798</team_members_id><team_members_names><![CDATA[ Doktorand: Dominik Anđelini ]]></team_members_names><keywords_hr><![CDATA[biougljen, GHG emisije, hraniva, klimatske promjene, vinova loza]]></keywords_hr><keywords_en><![CDATA[biochar, climate change, GHG emissions, grapevine, nutrients]]></keywords_en><summary_hr><![CDATA[Konvencionalno vinogradarstvo može dovesti do degradacije tala u smislu gubitka organske tvari tla, zbijanja tla i smanjene infiltracije vode, smanjenja sadržaja hraniva i akumulacije teških metala. S druge strane, znanstveni dokazi ukazuju da klimatske promjene predstavljaju dominantan izazov za vinogradarstvo u nadolazećim desetljećima, budući da emisije stakleničkih plinova, temperatura, oborine i drugi čimbenici mogu izravno utjecati na ekosustave. Predloženo istraživanje ima za cilj integrirati alate za ublažavanje ova dva vrlo aktualna problema globalnog vinogradarstva - klimatske promjene i degradaciju tla, koristeći koncept kružne ekonomije i valorizacije otpada, putem korištenja ostataka rezidbe vinove loze i njihovu transformaciju u biougljen. Cilj predloženog istraživanja je postići: moguće smanjenje emisije stakleničkih plinova u vinogradima; ublažavanje stresa od suše poboljšanjem kapaciteta tla za vodu; i održivo upravljanje ishranom vinove loze vraćanjem hraniva koja bi se inače nepovratno iznijela tijekom rezidbe. Nadalje, prema dostupnoj literaturi,  ovo će biti prvi eksperiment dugotrajne primjene biougljena u vinogradarskim tlima koje će istražiti i utjecaj na kvalitetu vina. Glavni elementi predloženog projekta su: a) prikupljanje i karakterizacija ostataka rezidbe vinove loze; b) laboratorijska proizvodnja i karakterizacija biougljena iz ostataka ostataka rezidbe (PRDB); c) proizvodnja i karakterizacija većih količina PRDB-a za primjenu u vinograd; d) stacionarni pokus u vinogradu (pet tretmana - PRDB, PRDB obogaćen UREA-om, ostaci rezidbe, gnojivo i kontrola; tri vegetacije će biti obrađene projektom, ali eksperiment će se nastaviti i nakon završetka projekta); e) eksperiment s folijarnim tretmanima (s ciljem razvoja novog proizvoda). Rezultati projekta bit će od praktične važnosti za poljoprivredni i vinogradarski sektor te obećavajući alat za ekološki prihvatljivo i održivo upravljanje ishranom vinove loze i ublažavanje klimatskih promjena.]]></summary_hr><summary_en><![CDATA[Conventional viticulture can lead to the degradation of soils in terms of soil organic matter loss, compaction and reduced water infiltration, reduction of nutrient content and heavy metal accumulation. On the other hand, scientific evidence sharply states that climate change represents a dominant challenge for viticulture in the upcoming decades, since GHG emission, temperature, precipitation, and other factors can directly impact ecosystems. The proposed research aims to integrate the tools for possible mitigation of this two present problems for global viticulture – climate change and soil degradation, using the concept of circular and zero-waste economy, via the valorization and utilization of grapevine pruning residues by their transformation into biochar. The proposed research aims to achieve: the possible reduction of vineyard GHG emissions; alleviation of drought stress by improving soil water holding capacity; and sustainable grapevine nutrient management by giving back the nutrients which will be otherwise lost during pruning. Furthermore, to our knowledge it will be the first experiment on biochar long-term vineyard soil application researching also the effect on wine quality. The main elements of the proposed project are: a) grapevine pruning residues collection and characterization; b) pruning-residues-derived biochar (PRDB) laboratory production and characterization; c) PRDB field-scale production and characterization; d) vineyard long-term experiment (five treatments – PRDB, PRDB enriched with UREA, pruning residues, fertilizer and control; three growing seasons are part of the project, but the experiment will continue after the end of the project); e) foliar treatments experiment (with the aim to develop a new product). The outcomes of the project will be of practical importance to the agricultural and viticultural sector and a promising tool towards environment-friendly and sustainable grapevine nutrient management and climate change mitigation.]]></summary_en></project><project>
<id>9395</id><title_hr><![CDATA[Relativna promjena morske razine i klimatske promjene  duž istočne obale Jadrana ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3367</user_id><user_firstLast_name>Sanja Faivre</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-9287</code><acronim><![CDATA[SEALeveL]]></acronim><duration>28.10.2020 - 26.10.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Interdisciplinarno područje znanosti</scie_area_hr><scie_area_en>Interdisciplinary scientific area</scie_area_en><scie_field_hr>Geografija, </scie_field_hr><scie_field_en>Geography, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>27028</team_members_id><team_members_names><![CDATA[ Doktorand: Marin Mićunović ]]></team_members_names><keywords_hr><![CDATA[promjena morske razine, klimatske promjene, algni vijenci, sige s fretskim obraštajem, obalna geomorfologija]]></keywords_hr><keywords_en><![CDATA[relative sea-level change, climate change, algal rim, phreatic overgrowths on speleothems, coastal geomorphology]]></keywords_en><summary_hr><![CDATA[Cilj predloženog projekt je istraživanje relativne promjene morske razine i klimatskih promjena duž istočne jadranske obale pomoću dva glavna markera algnih vijenaca i siga s fretaskim obraštajem. Algni vijenci koje gradi alga Lithophyllum byssoides pokazali su se dobrim indikatorom nekadašnje morske razine kod mikroplimnih obala, jer alge mogu živjeti samo u zoni plime i oseke te stoga predstavljaju najvišu biogenu konstrukciju u Mediteranu. Sige s freatskim obraštajem vrlo su rijetka pojava u špiljama obalnih područja gdje je razina podzemne vode određena morskom razinom. Formiranje freatskog obraštaja u uskoj zoni fluktuacije podzemne vode uzrokovane plimom i osekom te mogućnost preciznog određivanja njegove starosti čini ga izvrsnim indikatorom morske razine. Osim toga, špiljsko okružje u kojem nastaje štiti ga od erozije koja osigurava njegovo dugotrajno očuvanje. Oba markera, algni vijenci i sige s fretaskim obraštajem omogućuju određivanje indeksnih točaka promjene korištenih za konstruiranje krivulja relativne morske razine. Tako dobivene indeksne točke promjene povezati će se potom s fazama brzih klimatskih promjena na temelju analiza stabilnih izotopa dobivenih iz algnih vijenaca. Krivulje relativne promjene morske razine kvantificirati će se pomoću modela integriranog Gaussovog procesa s poznatom greškom varijabli (EIV-IGP). Krivulje relativne morske razine iz različitih dijelova Jadrana zajedno s podacima stabilnih izotopa iz alga predstavljati će osnovu za razumijevanje uzroka promjena: klimatske promjene, izostatički pomaci i tektonika. Istraživanje i razumijevanje kako i zašto se morska razina mijenjala u prošlosti omogućit će bolje procjene budućih promjena i procjene ranjivosti obalnih područja što može pomoći boljoj organizaciji i pripremi lokalne zajednice.]]></summary_hr><summary_en><![CDATA[The project aims to study the relative sea-level change and climate change along the eastern Adriatic coast by means of two principal sea-level indicators, algal rims and phreatic overgrowths on speleothems (POS). Rims of coralline rhodophyte Lithophyllum byssoides have proven to be a good proxy of past sea levels in microtidal environments because their living range is constrained around sea level. It thus creates the highest biogenic build-up in the Mediterranean. Phreatic overgrowths on speleothems (POS) are a rare occurrence in groundwater cave pools in coastal areas where groundwater level is controlled by sea level. Their formation in a narrow horizon within tide-induced groundwater fluctuation and the possibility of accurate dating makes POS an excellent sea-level indicator as well. In addition, the cave environment in which they occur protects them from erosion and thus ensures long-term preservation. Both, algal rims and POS allow the definition of sea-level index points (SLIP) used for the creation of relative sea-level curves. Obtained SLIPs from algal rims will be further related the periods of rapid climate changes by means of stable isotopes. The RSL changes will be quantified using an Error-In-Variables Integrated Gaussian Process (EIV-IGP) model. The relative sea-level curves from different parts of the eastern Adriatic coast together with stable isotope curves will represent the base for the understanding of driving mechanisms: climate changes, isostatic movements and tectonics. The study and understanding of relative sea-level changes in the past will allow better predictions of future changes and vulnerability estimation allowing community resilience to climate change.]]></summary_en></project><project>
<id>9396</id><title_hr><![CDATA[Eugen Savojski (1663.-1736.) i gradovi-tvrđave jugoistočne granice Habsburške Monarhije]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1226</user_id><user_firstLast_name>Milan Pelc</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-2293</code><acronim><![CDATA[EUGEN]]></acronim><duration>01.11.2020 - 30.04.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Povijest umjetnosti, </scie_field_hr><scie_field_en>Art history, </scie_field_en><institution_hr><![CDATA[Institut za povijest umjetnosti]]></institution_hr><institution_en><![CDATA[Institute of Art History, Zagreb]]></institution_en><team_members_id>861740</team_members_id><team_members_names><![CDATA[ Doktorand: Iva Vidović ]]></team_members_names><keywords_hr><![CDATA[Eugen Savojski, Habsbruška Monarhija, Hrvatska, gradovi-tvrđave, arhitektura, barok]]></keywords_hr><keywords_en><![CDATA[Eugene of Savoy, Hapsburg Monarchy, Croatia, Fortress-Towns, Architecture, Baroque]]></keywords_en><summary_hr><![CDATA[Osloboditelj istočnih dijelova Habsburške Monarhije od Osmanlija, princ Eugen Savojski (1663.–1736.), uz svoju briljantnu vojnu karijeru, istaknuo se i kao inicijator važnih urbanističkih i arhitektonskih zahvata. S jedne strane, njegova se graditeljska djelatnost odnosi na podizanje vlastitih rezidencija u samoj prijestolnici i različitim dijelovima Monarhije. Drugi dio graditeljske aktivnosti, koji je princ vodio kao predsjednik Dvorskog ratnog vijeća, odnosi se na gradove-tvrđave novoformirane granice prema Osmanskom Carstvu. Izgrađeni s upućenošću genijalnog stratega, oni ne znače samo primjenu najmodernijih bastionskih konstrukcija, već sadrže barokne ambijente visoke urbanističke i arhitektonske kvalitete. Strateški položaj današnje istočne Hrvatske u kontekstu nekadašnje austrijsko-turske granice rezultirao je činjenicom da se neki od najmarkantnijih utvrđenih gradova nalaze upravo na hrvatskom teritoriju – Osijek, Slavonski Brod, Stara Gradiška, Orlica – a s njima nedjeljivu cjelinu čini Petrovaradin. Iako formiranje većine navedenih gradova-tvrđava počinje prije Eugenove ere, i nastavlja se nakon njega, upravo im princ od Savoje daje ključni pečat. Angažiranjem vrhunskih vojnih inženjera, pogranične tvrđave po svojim fortifikacijskim sustavima mogu parirati projektima najpoznatijeg europskog graditelja utvrda – Vaubana (1633.–1707.). Istodobno, uključivanjem vodećih državnih arhitekata u projektiranje glavnih javnih i sakralnih zdanja unutar fortifikacijskih prstenova, hrvatska je arhitektura upravo ovdje obogaćena nekim antologijskim primjerima baroka. Budući da navedena tematika u nacionalnim okvirima još nije do kraja istražena, a međunarodnoj je znanstvenoj javnosti gotovo potpuno nepoznata, cilj je ovog projekta istražiti urbanizam i arhitekturu Osijeka, Slavonskog Broda, Stare Gradiške i Petrovaradina, te ih valorizirati u kontekstu drugih utvrda i rezidencija Eugena Savojskog (na području Austrije, Češke, Mađarske, Rumunjske i Srbije).]]></summary_hr><summary_en><![CDATA[The liberator of the eastern parts of the Hapsburg Monarchy from the Ottoman Turks, Prince Eugene of Savoy (1663–1736), in addition to his brilliant military career, was also initiator of important town-planning and architectural undertakings. One the one hand, his building activities concerned the construction his own residences in the capital city and various parts of the Monarchy. The second segment of his building activities, which the Prince headed as President of the Imperial War Council, concerned fortress-towns along the new boundary with the Ottoman Empire. They were built based on the knowledge of a strategic genius, they were not just the application of the most modern bastion structures but also contain Baroque ambiences of high urbanistic and architectural quality.    The strategic position of today’s eastern Croatian in the context of the former Austrian-Ottoman border resulted in some of the most imposing fortified towns being on Croatian territory - Osijek, Slavonski Brod, and Stara Gradiška. Although the formation of most of the fortress-towns began before Prince Eugene’s era, and continued after him, it was the Prince of Savoy that gave them a key signature. By engaging top military engineers, border fortresses and their fortification systems match projects of the most famous European fortress builder - Vauban. At the same time, by including leading state architects in designing the main public and religious buildings within the fortified encloses, Croatian architecture was here enriched by some anthological examples of Baroque. Since this theme has not been fully explored in the national context, and the international scientific public knows hardly anything about it, the aim of this project is to explore the urbanism and architecture of Osijek, Slavonski Brod, Stara Gradiška, Petrovaradin, and evaluate them in the context of Eugene of Savoy’s other fortifications and residences (on the territory of Austria, Bohemia, Hungary, Romania and Serbia).]]></summary_en></project><project>
<id>9397</id><title_hr><![CDATA[Imunomodulacijski učinci mastocita i eozinofila u mikrookolišu tumora mokraćnog mjehura]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5111</user_id><user_firstLast_name>Jelena Korać Prlić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-9351</code><acronim><![CDATA[emBC]]></acronim><duration>09.10.2020 - 09.06.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Split School of Medicine]]></institution_en><team_members_id>858366</team_members_id><team_members_names><![CDATA[ Doktorand: Lucija Franković ]]></team_members_names><keywords_hr><![CDATA[tumor mokraćnog mjehura, mikrookoliš tumora, mastociti, eozinofili, IL-33]]></keywords_hr><keywords_en><![CDATA[bladder cancer, tumor microenvironment, mast cells, eosinophils, IL-33]]></keywords_en><summary_hr><![CDATA[Tumori mokraćnog mjehura su šesti po učestalosti u muškaraca i imaju najveću stopu recidiva među tumorima. Liječenje tumora mokraćnog mjehura intravezikalnom instilacijom BCG cjepiva nakon transuretralne resekcije tumora daje vrlo uspješne rezultate u ranim fazama bolesti, no progresivni i ponavljajući tumori visokog gradusa, postaju otporni na taj oblik liječenja. Imunoterapijsko liječenje uznapredovalih tumora mokraćnog mjehura s PD-1/PD-L1 inhibitorima kontrolne točke pokazuje izvrsne rezultate, ali je ovaj vid terapije učinkovit tek u 20-30% pacijenata. Imunološke stanice su glavna komponenta mikrookoliša tumora, a uspješna primjena BCG cjepiva i inhibitora kontrolne točke ostvaruje svoje pozitivne učinke upravo djelovanjem na imunološke stanice. Mastociti i eozinofili su imunološke stanice redovito prisutne u mikrookolišu tumora mokraćnog mjehura, ali je njihova uloga tamo potpuno nepoznata. Cilj ovog projekta je istražiti ulogu mastocita i eozinofila u nastanku i razvoju tumora mokraćnog mjehura u svrhu poboljšavanja postojećih imunoterapijskih mogućnosti. Ulogu mastocita i eozinofila istraživat ćemo korištenjem mišjeg modela tumora mokraćnog mjehura induciranog kemikalijom N-butil-N-(4-hidroksibutil)-nitrozamin (BBN).  U istraživanju će se koristiti miševi kojima nedostaju mastociti i eozinofili (tzv. knock-out mišji modeli),  neutralizirajuća protutijela za uklanjanje mastocita i eozinofila kao i subkutani model tumora mokraćnog mjehura. Modulacijom učinaka mastocita i eozinofila u mikrookolišu tumora istražiti će se njihov protu-tumorski potencijal. Rezultati ovog projekta unaprijedit će razumijevanje uloge mastocita i eozinofila u tumorigenezi mokraćnog mjehura i pružit će osnove za daljnji razvoj liječenja tih tumora. Izmjena tumorskog mikrookoliša, djelovanjem na mastocite i eozinofile, ima velik potencijal u borbi protiv tumora mokraćnog mjehura koji recidiviraju ili su otporni na postojeće terapije.]]></summary_hr><summary_en><![CDATA[Bladder cancer is the sixth most common cancer in men and has the highest recurrence rate of all cancers. Intravesical therapy with BCG vaccine after the transurethral resection is an exemplary immunotherapeutic strategy for cancer management with a successful outcome in the early stages of the disease. However, progressive and recurrent bladder cancer becomes refractory to BCG. Immune checkpoint inhibitors targeting PD-1/PD-L1 axis were recently introduced in the management of locally advanced and metastatic bladder cancer, but the response rates are confined to 20-30%. Positive effects of BCG and checkpoint inhibitors depend on the activation of immune cells in the bladder cancer microenvironment. Mast cells and eosinophils are immune cells that are commonly found in bladder cancer microenvironment, but their role in bladder cancer pathogenesis remains elusive. Our aim is to investigate the role of mast cells and eosinophils during the initiation and progression of bladder cancer. The role of mast cells and eosinophils will be tested using a mouse model of bladder cancer induced with N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN), in wild type, as well as, in mast cell, and eosinophil knock-out (KO) mice. Furthermore, the role of mast cells and eosinophils will be re-evaluated by their depletion with neutralizing antibodies and by induction of subcutaneous tumors in mice. By modulating mast cell and eosinophil recruitment and activity in bladder cancer microenvironment, we will investigate their role in tumor pathogenesis. Results of this project will help clarify the functions of mast cells and eosinophils in bladder cancer tumorigenesis and will provide a basis for future improvements in bladder cancer immunotherapy.]]></summary_en></project><project>
<id>9398</id><title_hr><![CDATA[Alosterički komunikacijski putevi u oligomernim enzimima]]></title_hr><title_en><![CDATA[]]></title_en><user_id>424</user_id><user_firstLast_name>Zoran Štefanić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-3057</code><acronim><![CDATA[ALOKOMP/ALOCOMP]]></acronim><duration>15.02.2021 - 14.05.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>863807</team_members_id><team_members_names><![CDATA[ Doktorand: Boris Gomaz ]]></team_members_names><keywords_hr><![CDATA[alosterija, kristalografija, enzimska kinetika, molekulska dinamika, baze podataka, strojno učenje ]]></keywords_hr><keywords_en><![CDATA[allostery, crystallography, enzyme kinetics, molecular dynamics, databases, machine learning]]></keywords_en><summary_hr><![CDATA[Vjeruje se da alosterija (promjena svojstava enzima na jednom dijelu uzrokovana nekom drugom promjenom na udaljenom mjestu) igra ključnu ulogu u mehanizmu, aktivaciji i inhibiciji, te je od najveće važnosti za funkcioniranje enzima. No usprkos velikom značaju alosterije, njezin mehanizam je još uvijek nepoznat kod većine enzima. Unutar ovog projekta tom će se problemu pristupiti na inovativan način, kombinirajući nekoliko po sebi različitih metoda rijetko korištenih skupa u ovom kontekstu. Same 3D strukture enzima koje nam daje kristalografija rentgenskih zraka (XC), nisu u stanju objasniti u osnovi dinamičku sliku alostrije, te će one biti korištene kao polazne točke za molekulske simulacije (MD). Tako dobivene statičke (XC) i dinamičke (MD) slike enzima biti će povezane u obliku relacijske baze podataka. U ovom obliku te slike će biti idealne za pronalaženje skrivenih veza (putova) između različitih dijelova enzima, što i jest osnova alostrije. Zbog iznimne složenosti i količine podataka u takvoj bazi, u ovom projektu će se pribjeći algoritmima strojnog učenja (ML) koji će obrađivati ove visoko strukturirane podatke. Dakle glavni znanstveni cilj ovog projekta je objasniti mehanizam alosterije u oligomernim enzimima koristeći inovativni pristup u kojem se kombinira informacije dobivene različitim tehnikama: XC, MD i ML. Uz sam mehanizam alosterije unutar projekta će se pokušati razumjeti uloga oligomerizacije u svezi s alosterijom. U konačnici, pronađeni mehanizam alosterije biti će eksperimentalno potvrđen mutiranjem najvažnijih amino-kiselina u alosteričkim putovima pronađenim upotrebom ML algoritama te analizom promjene enzima do kojih dovode te mutacije. To će dati konačan dokaz valjanosti koncepta i algoritama te omogućiti njihovu primjenjivost u širem kontekstu drugih enzima.]]></summary_hr><summary_en><![CDATA[It is believed that allostery (a change in enzyme behaviour in one place caused by some other change at a distant location) plays a key role in enzyme mechanism, activation and inhibition, and is of paramount importance in enzyme functioning. In sharp contrast with its significance, the mechanism of allostery is still poorly understood in most enzymes. Current proposal will try to tackle this problem in a innovative way, by combining several very different methodologies that have seldom been used together in this context. As the 3D structure coming from X-ray crystallography (XC) alone is not capable to explain a fundamentally dynamic basis of allostery, it will serve as a basis for molecular dynamics (MD) simulations. Resulting static (XC) and dynamic (MD) data will be unified in a form of relational database. This database will be ideally suited for identifying hidden connections (pathways) between different enzyme regions, which is the basis of allostery. To address the complexity and the amount of data contained in the database, this proposal will leverage machine learning (ML) algorithms that will operate on this highly structured data. Therefore, the overall scientific objective of the project is to uncover the mechanism of allostery in oligomeric enzymes using a novel approach that combines the information obtained by different techniques: XC, MD and ML. Along with the mechanism of allostery, the project will try to understand the role of oligomerization in connection with allostery. Finally, the proposed allosteric mechanisms will be experimentally validated by mutating the most important residues in allosteric pathways found by ML algorithms and observing the change in enzyme behaviour upon mutations. This will then represent an ultimate proof of the validity of the concept and algorithms found in this project and show great prospect for their applicability in much broader domain of other enzymes. ]]></summary_en></project><project>
<id>9406</id><title_hr><![CDATA[Razvoj novih rješenja za karakterizaciju i zaštitu brončane kulturne baštine  izložene vanjskom okolišu]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5203</user_id><user_firstLast_name>Helena Otmačić Ćurković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-2627</code><acronim><![CDATA[BroCH]]></acronim><duration>10.09.2020 - 09.09.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Kemijsko inženjerstvo, </scie_field_hr><scie_field_en>Chemical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet kemijskog inženjerstva i tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Chemical Engineering and Technology]]></institution_en><team_members_id>855924</team_members_id><team_members_names><![CDATA[ Doktorand: Angela Kapitanović ]]></team_members_names><keywords_hr><![CDATA[kulturna baština, korozija, korozijska zaštita, organske prevlake, elektrokemijske tehnike]]></keywords_hr><keywords_en><![CDATA[cultural heritage, corrosion, corrosion protection, organic coatings, electrochemical techniques]]></keywords_en><summary_hr><![CDATA[Brončane skulpture izložene na javnim površinama su važan dio kulturne baštine, no korozivna gradska atmosfera uzrokuje njihovu degradaciju. Cilj ovog projekta je razviti nova rješenja za njihovu karakterizaciju te unapređivanje postupaka njihove zaštite. U tu svrhu, najprije će se spektroskopskim i elektrokemijskim tehnikama provesti detaljna karakterizacija izabranih urbanih brončanih skulptura na temelju kojih će se definirati uvjeti provedbe laboratorijskih istraživanja. Potom će se istražit mogućnost primjene dugolančanih organskih kiselina za poboljšanje adhezije organskih premaza, na bazi vode kao i na bazi organskih otapala, na brončanu podlogu čime bi se osigurala njena bolja i dugotrajnija korozijska zaštita. Utvrdit će se uvjeti pri kojima dolazi do nastanka čvrsto vezanog zaštitnog sloja organske kiseline u ovisnosti o metodi nanošenja i sastavu podloge te da li interakcija funkcionalnih skupina organske kiseline i premaza može dovesti do poboljšanja adhezije premaza. Zaštitna svojstva modificiranog premaza istražit će se ubrzanim korozijskim ispitivanjima uz primjenu ionizirajućeg zračenja i industrijske komore kao i elektrokemijskim ispitivanjima u elektrolitu koji simulira urbanu kišu.Dodatni inovativni aspekt ovog projekta je razvoj senzorskog dijela uređaja za određivanje korozijske stabilnosti brončanih skulptura. Elektrokemijske metode su temeljne metode za karakterizaciju korozijske stabilnosti materijala, no za njihovu provedbu uglavnom je nužno koristiti elektrokemijsku ćeliju s vodenim elektrolitom što otežava primjenu na realnim objektima zakrivljene geometrije. U projektu će se ispitati mogućnost konstruiranja jednostavne elektrokemijske ćelije s elektrolitom na bazi hidrogela odnosno vodljivom pastom koja bi bila primjenjiva za provođenje nedestruktivnih elektrokemijskih istraživanja brončanim skulpturama. Ćelija će se testirati na laboratorijskim i realnim uzorcima kako bi se utvrdila njena primjenjivost u praksi.]]></summary_hr><summary_en><![CDATA[Bronze sculptures exposed in public areas are an important part of cultural heritage, but corrosive urban atmospheres lead to their degradation. The aim of this project is to develop new solutions for their characterisation and to improve methods for their protection.Firstly, a detailed spectroscopic and electrochemical material characterization of selected bronze sculptures will be conducted in order to define key parameters for laboratory studies.Then the possibility of using long-chain organic acids for improved adhesion of solvent and water-based organic coatings on the bronze substrate will be examined. The conditions under which a strongly bonded organic acid layer is formed on the bronze surface will be determined, as well as whether the interaction between the functional groups of organic acids and coatings can lead to improved adhesion of the coating. The protective properties of the modified coatings will be investigated by accelerated corrosion tests using ionizing irradiation and an industrial chamber, as well as by electrochemical tests in electrolytes that simulate urban rain.An additional innovative aspect of this project is the development of an electrochemical cell for corrosion measurements that could be easily applied to bronze sculptures. Electrochemical methods are essential methods for characterizing the corrosion stability, but require the use an electrochemical cell with aqueous electrolyte, which makes it difficult to apply on real objects of curved geometry. This project will explore the possibility of designing a simple electrochemical cell with hydrogel or conductive paste electrolyte that would be applicable for conduction of non-destructive electrochemical testing on bronze sculptures. The cell will be tested on laboratory samples as well as on sculptures in order determine its practical applicability.]]></summary_en></project><project>
<id>9407</id><title_hr><![CDATA[Biokemijski odgovori površinskog sloja oligotrofnog područja Jadranskog mora na atmosfersko taloženje]]></title_hr><title_en><![CDATA[]]></title_en><user_id>106</user_id><user_firstLast_name>Slađana Strmečki Kos</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-7543</code><acronim><![CDATA[BiREADI]]></acronim><duration>01.10.2020 - 28.02.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>25845</team_members_id><team_members_names><![CDATA[ Doktorand: Saranda Bakija Alempijević ]]></team_members_names><keywords_hr><![CDATA[atmosfersko taloženje, površinski (mikro)sloj mora, Jadransko more, fitoplankton, hranjive soli, organska zagađivala, tragovi metala, površinski film]]></keywords_hr><keywords_en><![CDATA[atmospheric deposition, sea surface (micro)layer, Adriatic Sea, phytoplankton, macronutrients, organic pollutants, trace metals, surface films]]></keywords_en><summary_hr><![CDATA[Najizazovnija područja istraživanja globalnih klimatskih promjena danas uključuju kompleksna međudjelovanja biologije i kemije površinskih voda, atmosferske kemije te klime koja bi mogla imati još veći značaj u budućim klimatskim scenarijima. Koristeći multidisciplinarni, cjeloviti pristup, BiREADI ima za cilj ispitati utjecaje atmosferskog taloženja (AT) na složene biokemijske odgovore oligotrofnih vodenih sustava; primarno fitoplanktonskih zajednica te, posljedično, i na kemijske promjene u površinskim slojevima, uključujući mikrosloj na granici faza zrak-voda. Predložen je fazni pristup i specifični ciljevi: (I) procijeniti koncentracije, izvore i taložne tokove atmosferskih sastavnica te prirodu obogaćenja površinskih slojeva mora hranjivim solima, tragovima metala i organskim zagađivalima, (II) procijeniti utjecaje okolišnog AT na fiziologiju i biomasu prirodne planktonske populacije, a time i na kemiju površinskih slojeva mora, (III) dobiti uvid u mehanizme kojima AT utječe na morski fitoplankton, ali i procijeniti toksične učinke sinergijskog djelovanja atmosferskih zagađivala na različite razine biološke organizacije vodenih sustava, (IV) bolje razumijevanje prirode varijabilnosti biogene organske tvari  vodenih površinskih slojeva pod utjecajem AT te mehanizama stvaranja površinskih filmova i njihovih svojstava. BiREADI će značajno doprinijeti temeljnom razumijevanju povezanosti procesa AT i biokemijskih odgovora morskih površinskih sustava primjenom najsuvremenijih laboratorijskih ispitivanja, modeliranja, složenog terenskog rada, uključujući i mezokozmos na području srednjeg Jadrana–oligotrofnoj zoni i ključnom području proučavanja biokemijskih učinaka AT na Jadransko more.]]></summary_hr><summary_en><![CDATA[Complex interactions between surface water chemistry, phytoplankton, atmospheric chemistry, and climate are among the most challenging global climate issues today, and should become even more pronounced in future climate scenarios. With a holistic, multidisciplinary approach, the BiREADI is designed to assess the impact of atmospheric deposition (AD) on complex biochemical responses of oligotrophic systems, considering the importance of promotion and inhibition effects on phytoplankton, and the consequent altering of the surface water chemistry, including the sea surface microlayer at the air-water interface. To achieve the main project goals, a phased approach is proposed: Phase I - to evaluate concentrations, sources and deposition fluxes of atmospheric constituents, and to get insight into the nature of enrichments of macro-nutrients, trace metals and organic pollutants within the sea surface layers; Phase II - to assess the impact of ambient AD from diverse sources on the physiology and biomass of the natural plankton population, and consequently on the chemistry of the sea surface layers; Phase III - to get insight into the mechanisms by which AD affects marine phytoplankton, but also to assess the toxic effects of atmospheric pollutants that can interact synergistically on various levels of biological organisation in aquatic systems; Phase IV - to better understand the nature of biogenic OM variabilities within the aqueous surface layers affected by AD inputs with the consequences on the surface film formation and properties. The BiREADI will make a significant progress in the fundamental understanding of the linkage between AD inputs and complex surface ocean biochemical responses by a state-of-the-art laboratory and modelling studies, and by comprehensive field work including the mesocosm experiment at the Middle Adriatic - an extremely oligotrophic water zone and the «hotspot» area to study the biochemical effects of AD to the Adriatic Sea.]]></summary_en></project><project>
<id>9409</id><title_hr><![CDATA[Sustavni pristup modelima konsenzualne pravde u hrvatskom kaznenom postupku]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6266</user_id><user_firstLast_name>Zlata Đurđević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-8191</code><acronim><![CDATA[NegJusCro]]></acronim><duration>01.01.2021 - 31.12.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Pravo, </scie_field_hr><scie_field_en>Law, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Pravni fakultet u Zagrebu]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Law]]></institution_en><team_members_id>865285</team_members_id><team_members_names><![CDATA[ Doktorand: Darija Željko ]]></team_members_names><keywords_hr><![CDATA[konsenzualni postupci, konsenzualna pravda, nagodbe, kazneni postupak, kazneno pravosuđe]]></keywords_hr><keywords_en><![CDATA[consensual procedures, consensual justice, plea bargaining, criminal procedure, criminal justice]]></keywords_en><summary_hr><![CDATA[Hrvatski je zakonodavac posljednjih godina, pod utjecajem raznih stranih modela, uvodio različite oblike konsenzualnih postupaka, postupno šireći područje njihove primjene. Iz do sada provedenih istraživanja, moguće je uočiti da zakonodavac nije bio dosljedan kada je uređivao njihove različite aspekte koji se primjerice odnose na težinu kaznenih djela za koja je moguć pojedini oblik sporazuma, ulogu suda, ulogu žrtve, prava obrane i drugo. Poseban problem predstavlja to što nisu jasno izdiferencirani, niti na legislativnoj razini niti u praksi, specifični ciljevi koje bi pojedini oblici sporazumijevanja trebali ostvarivati. Nepreciznost i nekonzistentnost u regulaciji temeljnih aspekata različitih oblika konsenzualnih postupaka ne doprinose transparentnosti i kvaliteti kaznenog pravosuđa te u konačnici narušavaju povjerenje građana u pravosuđe. Predloženo istraživanje omogućit će sustavnu analizu problematike nagodbi primjenom temeljnih znanstvenih metoda. Nakon teorijske, normativne i poredbene analize, te istraživanja sudske i državnoodvjetničke prakse različitih oblika sporazumijevanja, provest će se empirijsko istraživanje primjenom metode polustrukturiranih intervjua te fokus grupa s ključnim sudionicima: sucima, državnim odvjetnicima i odvjetnicima. Iskustva ispitanika doprinijet će detektiranju i analizi ključnih nedostataka postojećeg normativnog okvira i prakse nagodbi. Završna studija u okviru projekta sintetizirat će rezultate provedenih istraživanja te će ponuditi konkretne prijedloge za izgradnju konzistentnog zakonskog okvira i transparentne prakse konsenzualnih postupaka, u skladu s europskim pravnim standardima i temeljnim načelima suvremenog kaznenog postupka.]]></summary_hr><summary_en><![CDATA[The Croatian legislator has lately introduced various forms of consensual procedures, influenced by foreign models, and has gradually expanded the scope of their application. From previous researches, it is possible to conclude that the legislator was not consistent when addressing various aspects of these proceedings, regarding for example the gravity of criminal offenses for which a particular form of agreement is possible, the role of the court, the role of the victim, the defence rights etc. A particular problem is that there are no clear distinctions, either at the legislative level or in practice, of the specific objectives of certain forms of agreements. Imprecision and inconsistency in the regulation of the fundamental aspects of various forms of consensual procedures do not contribute to the transparency and quality of the criminal justice and ultimately disturb citizens&#39; trust in criminal justice system. The proposed research will provide a systematic analysis of consensual justice, using basic scientific methods. After theoretical, normative and comparative analysis, as well as after the research of judicial and state attorneys’ practices of various consensual forms, an empirical research will be conducted using the method of semi-structured interviews and focus groups with key participants: judges, state attorneys and attorneys. The experience of the respondents will contribute to detecting and analysing the key deficiencies of the existing normative framework and practice. The final study will synthesize the results of the researches and will offer concrete proposals for building a consistent legal framework and transparent practices of consensual procedures in accordance with European legal standards and basic principles of contemporary criminal proceedings.]]></summary_en></project><project>
<id>9410</id><title_hr><![CDATA[In-silico potpomognut dizajn supstrata za hvatanje CO2 u katalitičkoj formaciji karbonata i karbamata]]></title_hr><title_en><![CDATA[]]></title_en><user_id>23209</user_id><user_firstLast_name>Dean Marković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-8818</code><acronim><![CDATA[INDICATIOR]]></acronim><duration>01.11.2020 - 01.11.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Interdisciplinarno područje znanosti</scie_area_hr><scie_area_en>Interdisciplinary scientific area</scie_area_en><scie_field_hr>Biotehnologija u biomedicini, </scie_field_hr><scie_field_en>Biotechnology in Biomedicine, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Fakultet biotehnologije i razvoja lijekova]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Biotechnology and Drug Development]]></institution_en><team_members_id>861746</team_members_id><team_members_names><![CDATA[ Doktorand: FIlip Vranješević ]]></team_members_names><keywords_hr><![CDATA[katalitičke ciklizacije, ugljični dioksid, karbonati, karbamati, in silico dizajn , mehanističke studije, biološke aktivnosti, komputacije]]></keywords_hr><keywords_en><![CDATA[catalitic cyclization reactions, carbon dioxide, carbonates, carbamates, in silico design, mechanistic studies, biological activities, computations]]></keywords_en><summary_hr><![CDATA[Dugoročni cilj podnositelja je usmjeriti svoje istraživačke napore prema in-silico utemeljenom racionalnom predviđanju ključnih kemijskih svojstava kao što su termodinamički i kinetički parametri kako bi se projektirali reaktanti i modulirala njihova reaktivnost s konačnom eksperimentalnom potvrdom računski postavljene hipoteze. Na toj liniji projekt se bavi korištenjem ugljičnog dioksida kao obnovljivog i jeftinog ugljičnog resursa u modernim metal kataliziranim ciklizacijama kako bi se učinkovito i jednostavno napravili karbonati i karbamati. Ove reakcije će upotrijebiti nezasićene alkohole i amine kao partnere za spajanje s ugljičnim dioksidom, da bi se formirali ciklički karbonati, odnosno karbamati. Glavna poteškoća za razvoj takvih novih procesa je relativno velika stabilnost CO2 ((DHf (CO2) ? -94 kcalmol-1), a time i inertnost koju treba prevladati. Za razliku od objavljenih postupaka koji uglavnom koriste jednostavne visoko energetske reaktante za hvatanje CO2 kako bi dobili potrebnu endergoničnost reakcije, plan ovog prijedloga je razviti novi racionalni, in silico potpomognut pristup kako bi se prilagodila reaktivnost supstrata za hvatanje CO2. U ovom slučaju potrebna endergoničnost reakcije dolazi od stabilizacije produkata kroz stvaranje dodatnih C-C veza. Za brzu optimizaciju reakcijskih uvjeta koristit će se trodimenzionalne kombinatorne metode. Ova metodologija će se primijeniti za sintezu alifatskih i aromatskih karbonata i karbamata. Budući da mnogi organski karbamati i karbonati imaju jaka biološka djelovanja, biblioteka sintetiziranih spojeva testirat će se in vitro za njihove antitumorske i antibiotske aktivnosti. Također će se istražiti mehanizam opisanih transformacija. Kako bi se prikupili mehanistički podaci i kako bi se u potpunosti razjasnili operativni mehanizmi uključeni u ove transformacije, eksperimentalni rezultati bit će dopunjeni računalnim studijama.]]></summary_hr><summary_en><![CDATA[The long-term goal of applicant is to direct his research efforts towards the in silico based rational prediction of the key chemical properties such as thermodynamic and kinetic parameters in order to design reactants and modulate their reactivities with final experimental confirmation of computationally imposed hypothesis. On this line the project deals with the employment of carbon dioxide as a renewable and inexpensive carbon resource in modern metal-catalyzed cyclization reactions to form carbonates and carbamates in efficient and simple manner. These reactions will employ unsaturated alcohols and amines with carbon dioxide as coupling partners in order to form cyclic carbonates and carbamates, respectively. The main difficulty for the development of such new processes is relatively large stability of CO2 (?Hf(CO2)? -94 kcalmol-1) and thus, inertness that should be overcome. In contrast to literature reported procedures that mostly use simple highly energetic reactants to trap CO2 in order to gain necessary endergonicity of the reaction, the plan of this proposal is to develop new rational in silico aided approach in order to adjust reactivity of substrate for CO2 trapping. The necessary endergonicity of the reaction would, come from the product stabilization through additional bonds formation. Three-dimensional combinatorial methods will be employed for the fast optimization of the reaction conditions. This methodology will be applied for the synthesis of aliphatic and aromatic carbonates and carbamates. As many of organic carbamates and carbonates have potent biological activities a library of synthetized compounds will be tested in vitro for their anticancer and antibiotic activities. The mechanism of the described transformations will be also studied. In order to collect mechanistic data and to fully elucidate the operative mechanism involved in these transformations, experimental results will be supplemented with computation studies.]]></summary_en></project><project>
<id>9411</id><title_hr><![CDATA[Safe Speed Anticipating for Encountering Pedestrian Crossing (Upravljanje brzinom autonomnog vozila pri prolasku preko pješačkog prijelaza)]]></title_hr><title_en><![CDATA[]]></title_en><user_id>11149</user_id><user_firstLast_name>Joško Deur</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-2938</code><acronim><![CDATA[]]></acronim><duration>15.01.2021 - 14.01.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, </scie_field_hr><scie_field_en>Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>862778</team_members_id><team_members_names><![CDATA[ Doktorand: Lea Pavelko ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>9412</id><title_hr><![CDATA[Terapijski potencijal neurosteroida i neurotrofina u demenciji]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1059</user_id><user_firstLast_name>Dubravka Švob Štrac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-3622</code><acronim><![CDATA[TePoNeDe]]></acronim><duration>28.10.2020 - 27.04.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>858339</team_members_id><team_members_names><![CDATA[ Doktorand: Barbara Vuić ]]></team_members_names><keywords_hr><![CDATA[neurosteroidi DHEA i DHEAS, neurotrofin BDNF, demencija, neuroprotekcija, stanični i animalni modeli, ispitanici ]]></keywords_hr><keywords_en><![CDATA[neurosteroids DHEA and DHEAS, neurotrophin BDNF, dementia, neuroprotection, cellular and animal models, human subjects]]></keywords_en><summary_hr><![CDATA[Demencija predstavlja sindrom globalnog i progresivnog propadanja kognitivnih sposobnosti, koji obično pogađa starije osobe. Kako se tijek demencije za sada ne može zaustaviti te s obzirom na ubrzano starenje stanovništva i produljenje životnog vijeka, u skoroj budućnosti demencija će postati jedan od vodećih globalnih problema. Neurosteroidi poput dehidroepiandrosterona (DHEA) i njegovog sulfata (DHEAS), kao i neurotrofini poput moždanog neurotrofnog čimbenika (BDNF), uključeni su u brojne važne funkcije mozga poput neuralne plastičnosti, učenja, pamćenja i ponašanja te pokazuju potencijal u prevenciji i liječenju demencija. Cilj projekta je istražiti neuroprotektivni potencijal i mehanizme djelovanja DHEA(S) i BDNF u demenciji, kombinacijom staničnih, animalnih i istraživanja na ispitanicima. Stanični i molekularni mehanizmi protektivnog djelovanja DHEA(S) i BDNF s posebnim naglaskom na ulogu PI3K signalnog puta istražiti će u primarnoj kulturi neurona C57BL/6 miša tretiranoj Aß-oligomerima kao in vitro modelu Alzheimerove bolesti (AB). Transgeničnim animalnim modelom AB (3xTg-AD miševi), istražiti će se mehanizmi protektivnog djelovanja DHEA(S), s fokusom na promjene BDNF-a i PI3K signalnog puta, in vivo testiranjem kognitivnih funkcija testovima ponašanja te ex vivo analizom patohistoloških, neurokemijskih i strukturnih promjena u tkivu i prerezima mozga, kao i metabolomskog profila u plazmi miševa. U ispitanika sa demencijama i blagim spoznajnim poremećajem (MCI), istražiti će se genetski (BDNF i SULT2A polimorfizmi) i epigenetski (DNA metilacija BDNF promotora) čimbenici uključeni u ekspresiju i regulaciju BDNF i DHEA(S) te povezanost njihove koncentracije u plazmi sa simptomima demencije. Dobiveni rezultati trebali bi pridonijeti boljem razumijevanju složene patofiziologije demencija, razvoju lako dostupnih biokemijskih, metabolomskih i (epi)genetičkih biomarkera u svrhu ranog otkrivanja i praćenja bolesti te novih pristupa u prevenciji i liječenju demencija.]]></summary_hr><summary_en><![CDATA[Dementia is a syndrome of global and progressive deterioration of cognitive skills, which usually affects the elderly. As dementia course for now cannot be halted, given the aging population and increased life expectance, dementia will become one of the leading global problems in near future. Neurosteroids dehydroepiandrosterone (DHEA) and its sulphate (DHEAS), as well as neurotrophin brain derived neurotrophic factor (BDNF) are involved in numerous brain functions such as neural plasticity, learning, memory and behaviour, showing potential in dementia prevention and treatment. The project aims to elucidate neuroprotective effects and mechanisms of DHEA(S) and BDNF in dementia by combining cellular, animal and human research. Cellular and molecular mechanisms of DHEA(S) and BDNF protective effects with emphasis on PI3K-Akt signalling pathway will be evaluated using primary C57BL/6 mouse neuronal culture treated with Aß-oligomers as in vitro model of Alzheimer’s disease (AD). Using transgenic animal AD model (3xTg-AD mice), mechanisms of DHEA(S) protective actions with focus on alternations in BDNF and PI3K signalling pathway, will be evaluated in vivo by behavioral testing of cognitive functions and ex vivo by analysis of pathohystological, neurochemical and structural changes in brain tissue and slices, as well as metabolomic profile in mouse plasma. In subjects with dementia and mild cognitive impairment (MCI), genetic (BDNF and SULT2A polymorphisms) and epigenetic (BDNF DNA methylation) factors, involved in BDNF and DHEA(S) expression and regulation, as well as association of their plasma concentrations with dementia symptoms will be evaluated. Obtained results should contribute to better understanding of complex cellular and molecular pathophysiology of dementia, development of easy available biochemical, metabolomic and (epi)genetic biomarkers for an early detection and disease course monitoring, as well as novel approaches in dementia prevention and treatment.]]></summary_en></project><project>
<id>9413</id><title_hr><![CDATA[Normativni modeli vaskularnih biomarkera za unapređenje stratifikacije kardiovaskularnog rizika u primarnoj i sekundarnoj prevenciji]]></title_hr><title_en><![CDATA[]]></title_en><user_id>2713</user_id><user_firstLast_name>Ana Jerončić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-2159</code><acronim><![CDATA[NormPreven]]></acronim><duration>04.02.2021 - 03.02.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Javno zdravstvo i zdravstvena zaštita, </scie_field_hr><scie_field_en>Public health and health services, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Split School of Medicine]]></institution_en><team_members_id>865290</team_members_id><team_members_names><![CDATA[ Doktorand: Pjero Koren ]]></team_members_names><keywords_hr><![CDATA[kardiovaskularni rizik, primarna i sekundarna prevencija, vaskularni biomarkeri, unapređenje procjene rizika, inovativni modeli   ]]></keywords_hr><keywords_en><![CDATA[cardiovascular risk, primary and secondary prevention, vascular biomarkers,  improvement in risk assessment, innovative models]]></keywords_en><summary_hr><![CDATA[Hrvatska ima visok mortalitet od kardiovaskularnih bolesti i stopu izbježive smrtnosti. Točna procjena ukupnog kardiovaskularnog (KV) rizika omogućuje rano otkrivanje osoba s rizikom i izbor optimalne preventivne skrbi. Tradicionalni modeli procjene KV rizika predviđaju rizik na razini populacije, ali nisu dovoljno točni u utvrđivanju rizika za pojedinca. Vaskularni biomarkeri (VB), pokazatelji ranog vaskularnog starenja, imaju velik potencijal za preciznije predviđanje pojedinačnog rizika.Projekt predviđa razvoj dva inovativna modela za procjenu KV rizika temeljena na VB, kao nadopunu tradicionalnim pristupima. Slučajno ćemo uzorkovati populaciju odraslih zdravstvenih osiguranika u Splitu i sakupiti njihove podatke o čimbenicima KV rizika, VB i drugim stanjima povezanim s vaskularnim oštećenjem, kao što su parodontitis, opstruktivna apneja u spavanju te kardiometabolički rizik. Model1 temelji se na robusnom grupiranju ispitanika s obzirom na različite VB što smo već opazili u velikoj kohortnoj studiji na populaciji Splita i što ukazuje na zajedničku vaskularnu strukturu unutar skupine. Testirat ćemo: a) replicira li se fenomen u našem uzorku, b) odražava li grupiranje stupanj vaskularne štete; c) je li u korelaciji s tradicionalnim modelom KV rizika. Model2 obuhvaća izradu normativnih jednadžbi centralnog augmentacijskog indeksa - surogatne mjere arterijske elastičnosti, na ispitanicima s niskim KV rizikom uz korištenje regresijskih modela specifičnih za spol i dobnu dekadu te uz dodatni prediktor što bi trebao poboljšati preciznost stratifikacije KV rizika. Modeli će se procjenjivati neizravno, putem slaganja sa SCORE modelom te procjenom njihove povezanosti s brojnim pokazateljima vaskularnog oštećenja. Provest će se i mnoštvo epidemioloških istraživanja.Očekujemo da ćemo izraditi obećavajuće modele za unapređenje procjene KV rizika, unaprijediti  znanje o epidemiologiji ispitivanih stanja i dati doprinos javno-zdravstvenim intervencijama utemeljenim na dokazima.]]></summary_hr><summary_en><![CDATA[Croatia is country with high burden of cardiovascular diseases, and amenable mortality. An accurate assessment of total cardiovascular (CV) risk enables early detection of people at risk and choice of optimal preventive treatment. Conventional models of CV risk assessment predict population attributable risk but lack sensitivity or specificity in identifying individual’s risk. Vascular biomarkers such as arterial stiffness indices are hallmarks of early vascular aging and have potential to predict this risk more accurately.We propose two innovative models for CV risk assessment that are based on vascular biomarkers and intended to complement traditional approaches. We will randomly sample adult primary care population from Split and collect data on CV risk factors, vascular biomarkers, and other conditions associated with vascular damage such as periodontitis and obstructive sleep apnea diagnoses, cardiometabolic risk. Model 1 is based on robust clustering of subjects according to various vascular biomarkers we had observed in large cohort; implying common vascular structure in a cluster. We will test if: a) phenomenon is replicated in our sample, b) clustering reflects the gradation of vascular damage; c) is correlated to traditional CV risk stratification model (SCORE). Model 2 foresees building of normative equations of central augmentation index, a surrogate measure of arterial stiffness, on data of low CV risk participants by using sex- and age-decade specific regression models and additional predictor which should improve precision of CV risk stratification. Models will be assessed indirectly via agreement with the SCORE model; and by evaluating their associations with numerous indicators of vascular damage. A multitude epidemiological research will also be performed.We expect to generate promising models for CV risk assessment, improve existing knowledge on epidemiology of screened conditions, and provide input for evidence-based public health interventions.]]></summary_en></project><project>
<id>9414</id><title_hr><![CDATA[Histološki, klinički, laboratorijski i genski prediktori ishoda bolesnika s Henoch-Schönleinovom purpurom i nefritisom]]></title_hr><title_en><![CDATA[]]></title_en><user_id>26821</user_id><user_firstLast_name>Marija Jelušić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-5076</code><acronim><![CDATA[PURPURAPREDICTORS]]></acronim><duration>01.11.2020 - 31.10.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Clinical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>861735</team_members_id><team_members_names><![CDATA[ Doktorand: Martina Held ]]></team_members_names><keywords_hr><![CDATA[Henoch-Schönleinova purpura, IgA vaskulitis, glomerulonefritis, biomarkeri, biopsija, histologija, djeca, tipizacija, polimorfizam, alarmini ]]></keywords_hr><keywords_en><![CDATA[Henoch-Schönlein purpura, IgA Vasculitis, Glomerulonephritis, Biomarkers, Biopsy, Histology, Children, HLA Typing, Polymorphism, Alarmins ]]></keywords_en><summary_hr><![CDATA[Ovaj je projekt fokusiran na Henoch-Schönleinovu purpuru (HSP), najčešći vaskulitis u dječjoj dobi. Iako se radi o bolesti koja je najčešće samoograničavajuća, do 60% djece s HSP-om razvije nefritis (HSPN) koji je gotovo jedini uzrok morbiditeta i mortaliteta, s vjerojatnošću razvoja kroničnog bubrežnog zatajenja u rasponu od 1 do 15%. Za potvrdu dijagnoze HSPN-a, odabir terapije i praćenje bolesnika važna je biopsija bubrega, no još uvijek ne postoji jedinstvena histološka klasifikacija. Biopsija bubrega invazivan je postupak s određenim komplikacijama te se ulažu veliki napori u iznalaženju manje invazivnih markera pomoću kojih bi se moglo predvidjeti koji će bolesnici razviti HSPN, imati lošiju prognozu i zahtijevati agresivnije postupke liječenja. U sklopu nacionalnog multicentričnog istraživanja u pet tercijarnih pedijatrijskih reumatoloških i nefroloških centara namjeravamo utvrditi primjenjivost imunoglobulina A1 bez galaktoze (Gd-IgA1), proteina visoke pokretljivosti iz skupine 1 (HMGB1), kalprotektina, protokadherina-1 i tiola pri predviđanju razvoja nefritisa, odnosno aktivnosti upale te u predviđanju trajanja bubrežne bolesti, utvrditi moguću povezanost polimorfizama gena HMGB1 i RAGE i razvoja HSPN-a, odrediti izražaj HMGB1 i stupanj infiltracije makrofaga u bubrežnom tkivu, identificirati alele HLA-DRB1 koji se javljaju s većom učestalošću u oboljelih u hrvatskoj populaciji, odrediti primjenjivost sekvencioniranja cijelog egzoma u oboljelih, ispitati moguće genske mutacije koje imaju ulogu u etiopatogenezi te utvrditi koja od najčešće korištenih patohistoloških klasifikacija najbolje predviđa težinu i ishod bubrežne bolesti. Očekujemo da se analizom navedenih parametara koji ukazuju na produljeno trajanje autoimunosnog procesa i predstavljaju rani prediktor oštećenja funkcije bubrega, mogu izdvojiti bolesnici s nepovoljnim tijekom bolesti kako bi se u budućim istraživanjima pronašla strategija sprječavanja progresije u završni stadij bubrežne bolesti.]]></summary_hr><summary_en><![CDATA[This project is focused on Henoch-Schönlein&#39;s purpura (HSP), the most common vasculitis in childhood. Although the disease is most often self-limiting, up to 60% of children with HSP develop nephritis. Chronic renal failure has been reported in 1% to 15% patients, and is the major cause of mortality and morbidity among children suffering from HSP. The confirmation of diagnosis of HSPN requires a renal biopsy, that has an important role for therapy selection and patient monitoring, but still there is no single histological classification. Biopsy is an invasive procedure with certain complications, and great efforts are being made to find less invasive markers that could predict which patients would develop HSPN, have a poor prognosis and require more aggressive treatment procedures. In a national multi-centre research in 5 Croatian University Centers for pediatric rheumatology and nephrology we intend to establish the value of galactose-deficient IgA1, high-mobility group protein box 1 (HMGB1), calprotectin, protocadherin-1 and thiols in prediction of HSPN development, activity of inflammation and prediction of disease duration, establish possible associtation of HMGB1 and RAGE gene polymorphisms and HSPN development, determine the expression of HMGB1 and the degree of macrophage infiltration in renal tissue, identificate the HLA-DRB1 alleles with higher frequency in Croatian population of HSP/HSPN patients, determinate the feasibility of whole exome sequencing in patients with HSP and HSPN, explore possible rare variants involved in the etiopathogenesis and establish which of the most frequently used histological classifications most significantly predict severity and renal outcome. We expect that with the analysis of the mentioned parameters we will be able to early identificate HSP patients with unfavourable renal outcomes, that will guide more intensive clinical care and help design future research aiming to prevent progression to end-stage kidney disease.]]></summary_en></project><project>
<id>9415</id><title_hr><![CDATA[LIFE Lynx - Sprječavanje izumiranja populacije risa u Dinaridima i jugoistočnim Alpama putem naseljavanja životinja i dugotrajne zaštite (LIFE16 NAT/SI/000634)]]></title_hr><title_en><![CDATA[]]></title_en><user_id>28997</user_id><user_firstLast_name>Tomislav Gomerčić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-2663</code><acronim><![CDATA[]]></acronim><duration>14.10.2020 - 13.04.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Veterinarska medicina, </scie_field_hr><scie_field_en>Veterinary medicine, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Veterinarski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Veterinary Medicine]]></institution_en><team_members_id>857306</team_members_id><team_members_names><![CDATA[ Doktorand: Silvia Blašković ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>9416</id><title_hr><![CDATA[Računalni model strujanja, poplavljivanja i širenja onečišćenja u rijekama i obalnim morskim područjima]]></title_hr><title_en><![CDATA[]]></title_en><user_id>28996</user_id><user_firstLast_name>Lado Kranjčević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-5116</code><acronim><![CDATA[]]></acronim><duration>16.11.2020 - 15.11.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Temeljne tehničke znanosti, </scie_field_hr><scie_field_en>Basic engineering sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Tehnički fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Engineering]]></institution_en><team_members_id>861723</team_members_id><team_members_names><![CDATA[ Doktorand: Marta Alvir ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>9417</id><title_hr><![CDATA[Diskografska industrija u Hrvatskoj od 1927. do kraja 1950-ih]]></title_hr><title_en><![CDATA[]]></title_en><user_id>143</user_id><user_firstLast_name>Naila Ceribašić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-7002</code><acronim><![CDATA[]]></acronim><duration>14.09.2020 - 13.12.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Etnologija i antropologija, </scie_field_hr><scie_field_en>Ethnology and anthropology, </scie_field_en><institution_hr><![CDATA[Institut za etnologiju i folkloristiku]]></institution_hr><institution_en><![CDATA[Institute of Ethnology and Folklore Research in Zagreb]]></institution_en><team_members_id>856130</team_members_id><team_members_names><![CDATA[ Doktorand: Dora Dunatov ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>9418</id><title_hr><![CDATA[Ispitivanje i modeliranje mehaničkog ponašanja bioosušenog otpada kao preduvjet energetske oporabe]]></title_hr><title_en><![CDATA[]]></title_en><user_id>742</user_id><user_firstLast_name>Igor Petrović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-9862</code><acronim><![CDATA[WtE]]></acronim><duration>02.11.2020 - 01.11.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Interdisciplinarne tehničke znanosti, </scie_field_hr><scie_field_en>Interdisciplinary technological sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Geotehnički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Geotechnical Engineering]]></institution_en><team_members_id>858370</team_members_id><team_members_names><![CDATA[ Doktorand: Dino Bosilj ]]></team_members_names><keywords_hr><![CDATA[bioosušeni MBO otpadni materijal, projektiranje bioreaktorskog odlagalita, otpad u energiju, mehaničko ponašanje otpada, konstitutivni modeli]]></keywords_hr><keywords_en><![CDATA[biodryed MBT waste material, bioractor landfill design, waste-to-energy, mechanical behavior of waste, constitutive modeling]]></keywords_en><summary_hr><![CDATA[Predloženi projekt orijentiran je na eksperimentalno ispitivanje i numeričko modeliranje mehaničkog ponašanja bioosušenog otpada. Biosušenje je varijacija aerobne razgradnje koja se primjenjuje za parcijalnu stabilizaciju komunalnog otpada. Nakon biosušenja otpad se upućuje u daljnju obradu gdje se izdvaja organski bogata sitnozrnata frakcija pogodna za odlaganje na bioreaktorsko odlagalište. Jednom odložena, ova se frakcija ponovno podvrgava postupku vlaženja, s ciljem energetske oporabe nastalog bioplina za proizvodnju toplinske i/ili električne energije. U RH postoje dva MBO postrojenja s izlaznim proizvodom pogodnim za odlaganje na bioreaktorsko odlagalište.U RH trenutno ne postoje bioreaktorska odlagališta iako Pravilnik o načinima i uvjetima odlaganja otpada (NN 114/15) prepoznaje bioreaktorska odlagališta. Kao jedan od razloga svakako se može istaknuti nedovoljan broj eksperimentalnih podataka o geotehničkim parametrima razmatranog otpada. Drugi razlog je nedostatak prikladnog numeričkog modela za ovu vrstu otpada. Uslijed ovih nedostataka projektiranje bioreaktorskih odlagališta nije moguće.Stoga je glavni cilj predloženog istraživanja razviti, na temelju utvrđenih eksperimentalnih podataka, prikladan konstitutivni model za opisivanje 3-D stanja naprezanja i deformacija sitnozrnate frakcije bioosušenog otpada. Razvijeni model mogao bi se koristiti za potrebe projektiranja bioreaktorskih odlagališta. Model bi svoju primjenu mogao naći ne samo u RH već i u drugim zemljama regije kod kojih MBO tehnologija tek treba biti implementirana.Rezultati ovog projekta omogućit će racionalniji pristup u projektiranju odlagališta otpada, kao i nadopunu Strategije gospodarenja otpadom Republike Hrvatske. Osim toga, rezultati pokusa će pružiti sveobuhvatan skup dobro kontroliranih, novih generičkih mjerila za računalnu validaciju različitih aspekata modeliranja MBO otpada te doprinijeti unaprjeđenju prediktivne snage modela za potrebe projektiranja odlagališta otpada.]]></summary_hr><summary_en><![CDATA[The proposed project is focused on the experimental investigation and numerical modelling of the biodryed waste. Biodrying is a variation of aerobic process which is used for partial stabilization of municipal waste. After biodrying process the waste is submitted for further processing to extract organically rich fine-grained fraction suitable for disposal on a bioreactor landfill. Once disposed, the waste is once again moisturized in order to energetically reuse produced biogas through generation of thermal and/or electrical energy. There are two operating MBT plants in Republic of Croatia whose final product is suitable for disposal on bioreactor landfill.There are no bioreactor landfills built on Croatian territory yet, although the Ordinance on the methods and conditions for the landfill of waste (OG 114/15; R Croatia) recognizes bioreactor landfills.The insufficient experimental data about geotechnical parameters of biodryed waste can be emphasized as one of the reasons. The second reason is the lack of the appropriate numerical model. Due to the mentioned obstacles, the proper design of bioreactor landfill is not feasible. The main goal of the proposal is to develop an appropriate constitutive model for general 3-D stress paths for the fine-grained fraction of biodryed waste. The proposed model can then be used as a design tool for bioreactor landfills. Since a lot of countries in the Danube area should implement waste treatment technologies, the usefulness of the proposed model is not strictly limited to Croatia.The obtained results will allow more rational landfill design and retrofit waste management strategies in Croatia.The experimental results will provide a comprehensive set of well controlled, novel generic benchmarks to computationally validate various modelling aspects of the biodryed MBT waste material and contribute towards its improved predictive power of proposed model for the landfill design purposes. ]]></summary_en></project><project>
<id>9419</id><title_hr><![CDATA[Bilinogojstvom do sekundarnih biljnih metabolita: primjena mineralnih hraniva i elicitora za povećanje koncentracije fenola u listu masline]]></title_hr><title_en><![CDATA[]]></title_en><user_id>12403</user_id><user_firstLast_name>Igor Pasković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-3872</code><acronim><![CDATA[PhytoFarmOL]]></acronim><duration>22.07.2020 - 07.04.2026</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Institut za poljoprivredu i turizam]]></institution_hr><institution_en><![CDATA[Institute of Agriculture and Tourism in Poreč]]></institution_en><team_members_id>855521</team_members_id><team_members_names><![CDATA[ Doktorand: Marin Cukrov ]]></team_members_names><keywords_hr><![CDATA[ishrana bilja, list masline, oleuropein, paunovo oko, oralno zdravlje]]></keywords_hr><keywords_en><![CDATA[plant nutrition, olive leaf, oleuropein, olive leaf spot, oral health]]></keywords_en><summary_hr><![CDATA[Fenolni spojevi oleuropein i hidroksitirosol smatraju se glavnim aktivnim spojevima lista masline za koje je dokazano antikancerogeno, protuupalno i antimikrobno djelovanje. Oleuropein i hidroksitirosol, ali i ostali fenoli, imaju specifičnu ulogu u zaštiti bilja i povećanju otpornosti na fitopatogene gljive što može biti od presudne važnosti za održivi uzgoj maslina općenito. Fenoli i polifenoli su sveprisutni spojevi u biljkama koji igraju važnu ulogu u obrambenom mehanizmu biljke domaćina u odnosu na filamentozne gljive. Važnost fenola, pored povećanja otpornosti biljke na patogene, očituje se i u proizvodnji funkcionalne hrane i nutraceutika te lijekova na prirodnoj bazi za liječenje oralnih bolesti. Potreba za pronalaskom novih terapijskih postupaka u liječenju patoloških stanja usne šupljine dovela je do povećanog interesa za upotrebu prirodnih supstrata.Dokazano je da poljoprivredna praksa može povećati sadržaj fenola u listu masline. Samo je nekoliko istraživanja do sada bilo usmjereno na proučavanje utjecaja mineralne ishrane na sastav fenola u listu masline. U ovom projektu planira se provesti cijeli niz eksperimenata kako bi se utvrdio utjecaj određenih mineralnih hraniva (N, Ca, Mg, Mn, Zn, Cu i B) i elicitora (fosfit i kalijev silikat) na sastav fenola u listu masline kod različitih sorata. Također ocijenit će se i utjecaj prethodnog odabranog mineralnog hraniva ili elicitora, koji se pokaže kao najučinkovitiji u povećanju razine fenola, na razvoj bolesti paunovo oko koje uzrokuje fitopatogena gljiva Venturia oleaginea (sin. Spilocaea oleaginea). Razvoj bolesti pratit će se na tretiranim maslinama u polju ili kontroliranim uvjetima u plasteniku. Učinak najboljeg tretmana bit će ispitan kroz kvalitetu maslinovog ulja na sorti Leccino uzgajanoj na različitim terroirima. U okviru ovog projekta također se planiraju provesti predklinička i klinička istraživanja utjecaja ekstrakta lista masline na kandidijazu usne šupljine.]]></summary_hr><summary_en><![CDATA[Oleuropein and hydroxytyrosol are considered the main active olive compounds and their health benefits thought their anti-carcinogenic, anti-inflammatory, and antimicrobial proprieties has been proven. Nevertheless, oleuropein and hydroxytyrosol as well as total phenols, have specific role plant protection and resistance against fungal pathogens which may be of crucial importance for olive sustainable growing. It has been noticed that phenolic and polyphenolic compounds, as pre-formed antibiotic compounds, are ubiquitous in plants and play an important role in host plant’s pre-existing chemical defences against filamentous fungi. The phenolics in olive leaves, beside upgraded resistance to fungal pathogens, may have potential in the production of functional food and nutraceuticals. They could be easily used as oral remedies in the treatment of stomatognatic pathological conditions, where the need of finding new therapeutic procedures has led to increased interest in the use of natural substrates. There are evidence that agricultural practices can increase phenolics in olive leaves. Only a few studies have been focused on studying the effects of olive mineral nutrition on the olive leaves phenolic profile. In this project, series of experiments are planned to be conducted in order to determine the effect of selected mineral elements (N, Ca, Mg, Mn, Zn, Cu, and B) and elicitors (phosphite and potassium silicate) on leaf phenolic profile of olive cultivars. The effect of previously selected mineral/elicitor treatment as the best phenolic enhancer, on the development of olive leaf spot (Venturia oleaginea - syn. Spilocaea oleaginea), will be tested under greenhouse and field conditions. The impact of best phenolic enhancer will be tested thought quality of olive oil on Leccino cultivar grown at different terroirs. The preclinical and clinical studies investigating the effect of olive leaf extract on oral cavity candidiasis will be conducted during this project as well.]]></summary_en></project><project>
<id>9421</id><title_hr><![CDATA[Nanokompoziti s perovskitima za fotovoltaike, fotokatalizu i senzoriku]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3922</user_id><user_firstLast_name>Andreja Gajović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-5601</code><acronim><![CDATA[NanoPeroPhotoSens]]></acronim><duration>03.12.2020 - 02.06.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>861726</team_members_id><team_members_names><![CDATA[ Doktorand: Vedran Kojić Kojić ]]></team_members_names><keywords_hr><![CDATA[perovskitni oksidi, BaTiO3, oksidni perovskiti na bazi Mn, nanostructure, nanokompoziti, fotovoltaici, fotokataliza, senzorika]]></keywords_hr><keywords_en><![CDATA[perovskite oxides, BaTiO3, Mn-based oxide perovskites, nanostrucures, nanocomposites, photovoltaics, photo-catalysis, sensing]]></keywords_en><summary_hr><![CDATA[Projekt će biti nastavak istraživanja provedenih u prethodnom razdoblju, posvećenih mogućnosti podešavanja svojstava tankih filmova za uporabu u fotoosjetljivim uređajima, modificiranjem njihove strukture i sastava. Istraživati će se nano-strukture i nanokompoziti koji imaju poseban oblik, kao što su nanocjevčice, nano-štapići i vrlo tanki slojevi. Za dodatnu prilagodbu svojstava, modificirat će se kemijski sastav i struktura površine filmova elektrokemijskim jetkanjem, prekrivanjem nanočesticama i tretmanom u reaktivnim plinovima. Podrška eksperimentalnom radu u postizanju ciljanih svojstava za fotonaponsku, senzorsku i fotokatalitičku primjenu, bit će teorijska predviđanja temeljena na DFT računu elektronske strukture pojedinih materijala i nanokompozita. Eksperimenti na ZnO i TiO2, provedeni u prethodnom projektu, bit će prošireni na oksidne materijale koji imaju perovskitnu strukturu, počevši od BaTiO2 i perovskita na bazi Mn. U daljnjim koracima, funkcionalnost istraživanih tankih filmova će biti istražena njihovom integracijom u dvoslojne i višeslojne strukture relevantne za pojedinu vrstu fotoosjetljivih uređaja.Za pripravu i modifikaciju tankih filmova će se koristiti razne fizikalne i kemijske metode. Strukturna i funkcionalna svojstva će se određivati standardnim tehnikama i korelirati s parametrima formiranja, što će omogućiti bolji uvid u procese relevantne za rast tankog filma. Dobiveni eksperimentalni podaci, u kombinaciji s teorijskim predviđanjima temeljenim na DFT izračunima, rezultirati će boljim razumijevanjem utjecaja sastava i nanostrukture na makroskopska svojstva. Ovo će omogućiti procjenu u kojoj mjeri je moguće, postupcima korištenim u projektu, poboljšati svojstava fotovoltaika, fotokatalizatora i senzora. Dobiveni rezultati će biti objavljeni u časopisima s visokim faktorom odjeka iz područja znanosti o materijalima.Projekt će biti djelomično posvećen obrazovanju diplomskih i doktorskih studenata što podrazumijeva i razvoj novih karijera.]]></summary_hr><summary_en><![CDATA[Project will be continuation of research conducted in the previous period, devoted to exploring possibility of tailoring thin film properties by structural and compositional modification, for use in photosensitive devices. The nano-sized structures and nanocomposites with specific shape as nanotubes, nanorods and thin layers will be investigated. For additional adjustment of properties, the surface chemistry and structure will be modified by electrochemical etching, decoration with nanoparticles and treatment in reactive gases. The achievement of preferred properties targeting for the photovoltaic, sensing and photo-catalytic application will be supported by prediction of theoretical study, based on DFT calculation of electronic structure of individual materials and nanocomposites. The experiments on ZnO and TiO2, done in previous project, will be extended on oxide materials having perovskite structures, starting with BaTiO2 and Mn based perovskites. In further steps, the functionality of studied thin films will be tested by integration in bi-layer and multilayer structures as a part of photosensitive device.For preparation and modification of thin films, various physical and chemical methods will be used. Their structural and functional properties will be determined by using standard techniques and correlated with parameters of formation, enabling better insight into the processes relevant for the thin film growth. The obtained experimental data, combined with theoretical predictions based on DFT calculations, will lead to better understanding of the influence of composition and nanostructure on macroscopic properties. It will enable the evaluation of possibilities of using applied approaches for improving properties of photovoltaics, photo-catalysts and sensors. The results will be published in the high ranking journals in the field of material science.Project will be partially devoted to education of the graduate and PhD students implying new careers development.]]></summary_en></project><project>
<id>9422</id><title_hr><![CDATA[Glikozilacija proteina u bolestima povezanim sa starenjem kroz istraživanje preuranjenog starenja u Downovom sindromu]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5420</user_id><user_firstLast_name>Gordan Lauc</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-7170</code><acronim><![CDATA[GlycoDown]]></acronim><duration>01.09.2020 - 31.08.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[GENOS d.o.o. ]]></institution_hr><institution_en><![CDATA[GENOS Ltd ]]></institution_en><team_members_id>862781</team_members_id><team_members_names><![CDATA[ Doktorand: Helena Deriš ]]></team_members_names><keywords_hr><![CDATA[Glikozilacija proteina, Downov sindrom, starenje, Alzheimerova bolest, inducirane pluripotentne matične stanice]]></keywords_hr><keywords_en><![CDATA[Protein glycosylation, Down Syndrome, Ageing, Alzheimer’s Disease, induced pluripotent stem cells]]></keywords_en><summary_hr><![CDATA[Hrvatska (i cijela Europa) imaju vrlo nepovoljne demografske trendove. Oni uključuju porast udjela starog stanovništva i povećanje učestalosti bolesti povezanih sa starenjem. Nedavno je istraživačka grupa Prof. Lauca pokazala da je obrazac glikozilacije imunoglobulina G (IgG) dobar biomarker kronološke dobi, biološkog starenja te sistemske upale.Downov sindrom (DS) (trisomija 21 (T21)) uzrokuje izrazito ubrzano starenje na razini stanica i organizma kao cjeline te stoga predstavlja odličan sustav za proučavanje ubrzanog starenja. Ipak, značajni broj osoba s DS je zaštićen od bolesti povezanih sa starenjem, kao što je Alzheimerova demencija (AD). Prof. Nižetić je međunarodno prepoznati istraživač u proučavanju DS, a njegova grupa je nedavno napravila novi izogenski model induciranih pluripotentnih matičnih stanica (iPSC) za DS.Glikozilacija proteina nije do sada bila sistematično istraživana u kontekstu Downovog sindroma (DS). Naši preliminarni podaci dobiveni analizom uzoraka plazme 10 osoba s DS su nakon usporedbe s podacima zdravih osoba koje su im odgovarale po dobi pokazali da vrijednosti za neke IgG glikane značajno odskaču u osoba s DS, ukazujući da je pokazatelje ubrzanog starenja moguće detektirati analiziranjem poremećaja u glikomu u DS.Ciljevi: (i) odrediti glikozilaciju IgG u Downovom sindromu (DS) analiziranjem 300 osoba s DS iz tri europske populacije. Napravit će se i analiza vezana uz komorbiditete koji se javljaju uz DS, osobito rani ili kasni/bez razvoj(a) AD; (ii) istražiti utjecaj određenih genskih produkata kromosoma 21 na glikozilacijski profil; (iii) ustanoviti utjecaj T21 na glikanski profil usporedbom isogenskih iPSC-ova koji se razlikuju samo po prisutnosti T21; (iv) analizirati potencijal glikanskih biomarkera u predviđanju rane AD usporedbom glikanskog profila iPSC-ova (i dobivenih neurona) dobivenih iz uzoraka osoba s DS s ranom demencijom (u njihovim 30-ima) i osoba s DS bez demencije u dobi >60 godina.]]></summary_hr><summary_en><![CDATA[Croatia (and the whole of Europe) are suffering from the most unfavourable demographic trends They include high population-ageing rates and an increasing incidence of age-related diseases. Recently, Prof. Lauc’s team discovered that immunoglobulin G (IgG) glycome pattern is an accurate biomarker of chronological and biological ageing, as well as systemic inflammation.Down’s Syndrome (DS) (trisomy 21 (T21)) causes extremely accelerated cellular and organism ageing and is therefore an excellent model of accelerated ageing. However, despite this, significant cohorts of people with DS are protected from ageing-related diseases, such as Alzheimer’s dementia (AD). Prof. Nižetić is an internationally leading researcher in DS and his team recently developed a new isogenic induced pluripotent stem cell (iPSC) model of DS.Protein glycosylation has never been systematically studied in the context of Down Syndrome. In our preliminary data from plasma samples of 10 DS individuals, compared to age-matched euploids, we detected extreme values in several glycan forms of IgG, indicating that markers of extremely accelerated ageing can be detected by studying glycome perturbations in DS.Aims: i) determine glycosylation of immunoglobulin G (IgG) in Down Syndrome (DS) by analysing 300 individuals with DS from 3 European population. In addition, they will be analysed based on co-morbidities, in particular early or late/absent onset of AD; (ii) examine the effect of specific chromosome 21 gene products on the glycosylation profiles; (iii) establish the effects of T21 on glycan profiles by comparing isogenic iPSCs that differ only on the presence of T21; (iv) search for novel glycan biomarkers predictive of early AD by comparing same glycan profiles in iPSCs (and derived neurons) from DS subjects with early dementia (in their 30s) with DS subjects with no dementia at age >60.]]></summary_en></project><project>
<id>9424</id><title_hr><![CDATA[Model slobodnog odlučivanja o karijeri:  Uloga autonomne karijerne motivacije te zaštitnih i rizičnih faktora u profesionalnom razvoju adolescenata]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1178</user_id><user_firstLast_name>Iva Šverko</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-2684</code><acronim><![CDATA[FreeCareerChoice]]></acronim><duration>07.12.2020 - 06.06.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Psihologija, </scie_field_hr><scie_field_en>Psychology, </scie_field_en><institution_hr><![CDATA[Institut društvenih znanosti Ivo Pilar]]></institution_hr><institution_en><![CDATA[Institute of Social Sciences Ivo Pilar in Zagreb]]></institution_en><team_members_id>861524</team_members_id><team_members_names><![CDATA[ Doktorand: Dora Popović ]]></team_members_names><keywords_hr><![CDATA[Razvoj karijere, Model slobodnog odlučivanja o karijeri, autonomna karijerna motivacija, zaštitni i rizični faktori u karijeri, Put karijere]]></keywords_hr><keywords_en><![CDATA[Career development, Model of Free Career Choice, autonomous career motivation, protective and risk factors in career, The Career Path]]></keywords_en><summary_hr><![CDATA[Projekt FreeCareerChoice usmjeren je ispitivanju procesa odlučivanja o karijeri tijekom adolescencije. Teorije izbora i razvoja karijere uglavnom se ne bave širokim spektrom zaštitnih i rizičnih faktora koji djeluju na slobodu izbora zanimanja, niti se posvećuju motivacijskim procesima koji pokreću mlade ljude na odlučivanje o svom zanimanju. U okviru ovog projekta predlažemo Model slobodnog odlučivanja o karijeri u kojem naglašavamo ulogu zaštitnih i rizičnih faktora te autonomne karijerne motivacije u profesionalnom razvoju adolescenata. Smatramo da zaštitni i rizični faktori i autonomna karijerna motivacija, uz profesionalnu zrelost, djeluju na kvalitetu odabira karijere i posljedično na profesionalne ishode. U istraživanju će sudjelovati učenici osnovnih i srednjih škola dobi od 11 do 19 godina. Tri temeljna istraživačka cilja su (1) operacionalizacija konstrukta autonomne karijerne motivacije, (2) provjera uloge autonomne karijerne motivacije te zaštitnih i rizičnih faktora u modelu slobodnog odlučivanja u karijeri te (3) nadogradnja online sustava za profesionalno usmjeravanje Put karijere i evaluacija njegove učinkovitosti. Projekt uključuje tri nezavisna kvantitativna istraživanja (krossekcijsko i longitudinalno istraživanje te kvazieksperiment) te nekoliko manjih kvalitativnih studija. Rezultati istraživanja će osim znanstvenih publikacija i diseminacije uključivati i nadogradnju sustava za profesionalno usmjeravanje Put karijere koji će biti besplatan i javno dostupan svim korisnicima.]]></summary_hr><summary_en><![CDATA[The FreeCareerChoice project is focused on examining the career decision-making process during adolescence. Career theories largely do not deal with a wide range of protective and risk factors that can affect freedom of career choice and development, nor with motivational processes underlying career decisions of adolescents. Within this project we propose the Model of Free Career Choice, in which we emphasize the role of protective and risk factors and autonomous career motivation in the career development of adolescents. We believe that protective and risk factors and autonomous career motivation, along with career maturity, affect the quality of career choice and consequently related career outcomes. Primary and secondary school students from 11 to 19 years of age will participate in the research. The three fundamental research goals are (1) to operationalize the construct of autonomous career motivation, (2) to examine the role of autonomous career motivation and protective and risk factors in the Model of Free Career Choice, and (3) to upgrade the online career guidance system for students and evaluate its effectiveness. The project involves three independent quantitative studies (cross-sectional and longitudinal study and quasi-experiment) and several smaller qualitative studies. The research results will include, in addition to scientific publications and dissemination, the upgrading of the career guidance system The Career Path that will be free and publicly accessible to all users.]]></summary_en></project><project>
<id>9427</id><title_hr><![CDATA[Renewable and Waste Heat Recovery for Competitive District Heating and Cooling Networks (REWARDHeat)]]></title_hr><title_en><![CDATA[]]></title_en><user_id>13036</user_id><user_firstLast_name>Tomislav Pukšec</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-9456</code><acronim><![CDATA[]]></acronim><duration>01.10.2020 - 30.11.2023</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, </scie_field_hr><scie_field_en>Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>858327</team_members_id><team_members_names><![CDATA[ Doktorand: Ana Lovrak ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>9429</id><title_hr><![CDATA[Višeskalni problemi u mehanici fluida]]></title_hr><title_en><![CDATA[]]></title_en><user_id>817</user_id><user_firstLast_name>Igor Pažanin</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-2801</code><acronim><![CDATA[MultiFM]]></acronim><duration>02.12.2020 - 01.12.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>858439</team_members_id><team_members_names><![CDATA[ Doktorand: Borja Rukavina ]]></team_members_names><keywords_hr><![CDATA[tanka domena, hrapavi rub, poroelastična stijenka, tok fluida, asimptotičke metode, matematički modeli višeg reda, rigorozno opravdanje    ]]></keywords_hr><keywords_en><![CDATA[thin domain, rough boundary, poroelastic wall, fluid flow, asymptotic methods, higher-order mathematical models, rigorous justification]]></keywords_en><summary_hr><![CDATA[Višeskalni problemi, u kojima se mali (ili veliki) parametar pojavljuje u fizikalnim koeficijentima ili u domeni geometrije koju promatramo, prirodno se pojavljuju u mehanici fluida te ih možemo smatrati svakodnevnim fenomenima (cjevovodi, krvožilni sustav, lubrikacijski uređaji, tokovi u poroznoj sredini, itd). Cilj projekta MultiFM predložiti je i analizirati matematičke modele višeg reda koji opisuju razne višeskalne procese u mehanici fluida. Projekt MultiFM okuplja produktivne istraživače mlađe generacije s značajnom međunarodnom reputacijom i rezultatima u području. Proučavat će se tok fluida u (tankim) domenama čiji su stijenke nepropusne, ali mogu biti i porozne ili čak poroelastične. Namjerava se istraživati efekte hrapavih rubova domene kod problema lubrikacije, te proučavati slabo propusne domene poput porozne sredine. Fluidi koje ćemo promatrati biti će klasični newtonovski fluidi, ali veliku pažnju posvetit ćemo i ne-newtonovskim fluidima (power-law fluidi, mikropolarni fluidi). Fluidi mogu biti u jednoj (tekućoj) fazi, a bavit ćemo se i višefaznim fluidima gdje dvije faze egzistiraju zajedno. Inspirirani primjenama, zadavat ćemo nestandardne, ali fizikalno relevantne rubne uvjete i baviti se raznim fizikalnim procesima koji se prirodno događaju kod fluida. Obzirom da nije moguće analitički odrediti rješenja jednadžbi koja dolaze od originalnih zakona sačuvanja, analiza se bazira na teoretskom proučavanju odgovarajućih parcijalnih diferencijalnih jednažbi. Unfolding metode, tehnike višeskalnih razvoja, entropijske metode, Faedo-Glerkinov pristup biti će korišteni u procesu. Formalno izvedeni modeli opravdat će se teorijskom analizom pogreške i numeričkim simulacijama. Kako su istraživačke teme zahtjevne s matematičke točke gledišta i motivirane primjenama iz stvarnog života, rezultati projekta doprinijet će razvitku matematičke mehanike fluida i pokazati se korisnima za inženjersku praksu također.]]></summary_hr><summary_en><![CDATA[Multiscale problems, in which small (or large) parameter appears either in physical coefficients, or in domain geometry, naturally arise in fluid mechanics and can be considered as the everyday phenomena (pipelines, blood circulation system, lubrication devices, porous medium flows, etc.). The goal of the project MultiFM is to derive and analyse higher-order mathematical models describing various multiscale processes in fluid mechanics. The project gathers internationally recognized and productive researchers of the younger generation with major results in the field. We will address the fluid flow through (thin) domains whose walls are rigid, but also could be porous or even poroelastic. We plan to explore the effects of boundary irregularities on the lubrication problems, and to study the low permeability domains such as porous media. The fluids considered will be classical Newtonian fluids, but most attention will be devoted to non-Newtonain fluids (power-law fluids, micropolar fluids). They can be either in one (liquid) phase but we will also investigate multiphase fluids where two phases exist together. Inspired by the applications, non-standard but physically relevant boundary conditions will be imposed and different physical processes occurring in the fluids will be considered. Since we cannot obtain the solutions of the equations coming from the original conservation laws, the analysis is based on theoretical study of the governing partial differential equations. The unfolding methods, multiscale expansion techniques, entropy-based methods, Faedo-Galerkin approach will be used in the process. Formally derived models will be justified via theoretical error analysis and numerical simulations. Since the research topics are demading from the mathematical point of view and motivated by the real-life applications, the project results will contribute to the development of the mathematical fluid mechanics and prove useful in the engineering practice as well.]]></summary_en></project><project>
<id>9431</id><title_hr><![CDATA[Integrativna analiza signalnih puteva fitohormona uključenih u odgovor biljaka krumpira na infekciju viroidom vretenastoga gomolja krumpira]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5012</user_id><user_firstLast_name>Snježana Mihaljević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-7139</code><acronim><![CDATA[PotatoSignalHub]]></acronim><duration>14.12.2020 - 13.06.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>861744</team_members_id><team_members_names><![CDATA[ Doktorand: Iva Marković ]]></team_members_names><keywords_hr><![CDATA[analiza transkriptoma, fitohormoni, jasmonska kiselina, krumpir, miRNA, razvoj simptoma, signalni putovi, salicilna kiselina, viroid, PSTVd]]></keywords_hr><keywords_en><![CDATA[jasmonic acid, miRNA, phytohormones, potato, PSTVd, salycilic acid, signaling pathways, symptome development, transcriptome analysis, viroid]]></keywords_en><summary_hr><![CDATA[Viroid vretenastoga gomolja krumpira (Potato spindle tuber viroid, PSTVd) je najvažniji subviralni patogen krumpira (Solanum tuberosum L.). Zbog široke rasprostranjenosti u svijetu i patogenog učinka na mnoge poljoprivredne kulture, zaraza viroidom PSTVd može predstavljati ograničenje u proizvodnji hrane. Molekularni mehanizmi kojima viroidi induciraju kompleksne promjene u ekspresiji gena i metabolizmu biljaka domaćina nisu u potpunosti razjašnjeni. Novija saznanja ukazuju  da fitohormoni posreduju u regulaciji mnogih signalnih putova uključenih u interakciju biljaka i viroida. Glavni cilj ove studije je analizirati dinamiku odgovora biljaka krumpira na infekciju viroidom PSTVd kako bi dobili uvid u fitohormonima-posredovane odgovore na infekciju i pojasnili ulogu fitohormona u razvoju simptoma. U ovoj studiji provesti ćemo sustavno istraživanje ekspresije gena i endogenih fitohormona kako bi bolje razumjeli fiziološko značenje promjena u statusu fitohormona tijekom napredovanja bolesti. Doprinos jasmonske kiseline (JA) i salicilne kiseline (SA) u odgovoru na infekciju viroidom PSTVd  istražit ćemo koristeći transgenične linij e krumpira koje nemaju mogućnost nakupljanja JA i SA, kako bi utvrdili može li nedostatak fitohormona biti povezan sa sistemskim odgovorom i karakteristikama simptoma. Analizu transkriptoma listova sistemski zaraženih ne-transgeničnih i transgeničnih linija krumpira provesti ćemo kako bi dobili detaljan uvid u diferencijalno eksprimirane gene uključene u signalne putove fitohormona i njihove interakcije. Nadalje, promjene u ekspresiji tih gena biti će uspoređen s profilom ekspresije nekih konzerviranih miRNA s ciljem identificikacije miRNA uključenih u modulaciju signalnih putova fitohormona tijekom odgovora krumpira na zarazu viroidom PSTVd. Nova saznanja mogu pridonijeti boljem razumijevanju kompleksnih interakcija biljaka i viroida te pomoći razvoj strategija za zaštitu biljaka od ovog patogena.]]></summary_hr><summary_en><![CDATA[Potato spindle tuber viroid (PSTVd) is the most important subviral pathogen of potato (Solanum tuberosum L.). Due to its worldwide distribution and its capacity to cause disease in many important crop plants, PSTVd is one of the main constraints on food production. The molecular mechanisms by which viroids induce complex changes in host gene expression and metabolism are not fully understood. Current findings indicate that many signal transduction pathways involved in plant-viroid interactions are mediated by phytohormones. The main goal of this study is to analyze the dynamic of potato-PSTVd interaction, in order to obtain a more comprehensive view of phytohormone-mediated responses to PSTVd infection, and to clarify their role in symptom development. During the study, a systematic exploration of gene expression and endogenous phytohormones along the progression of disease will be conducted to better understand the physiological meaning of changes in the status of phytohormones associated to viroid infection. To assess the contribution of jasmonic acid (JA) and salicylic acid (SA) in response to PSTVd infection, JA- and SA-deficient transgenic potato lines will be used in order to determine whether the lack of phytohormones could be implicated in the systemic response and symptom characteristics.  Transcriptome analysis in leaves of systemically infected non-transgenic and transgenic potato lines will be employed to achieve higher resolution of differentially expressed genes (DEGs) involved in phytohormone signaling pathways and their crosstalk. In addition, the profiles of DEGs will be compared with profiles of some conserved miRNAs to identify viroid-responsive miRNAs implicated in the modulation of phytohormone signaling in potato during PSTVd infection. New findings can contribute to better understanding of the complexity of plant-viroid interactions and to support the development of new strategies for plant protection against viroids.]]></summary_en></project><project>
<id>9433</id><title_hr><![CDATA[Nucleolar control of megakaryopoiesis]]></title_hr><title_en><![CDATA[]]></title_en><user_id>35</user_id><user_firstLast_name>Antonija Jurak Begonja</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-4154</code><acronim><![CDATA[]]></acronim><duration>30.12.2020 - 30.08.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Interdisciplinarno područje znanosti</scie_area_hr><scie_area_en>Interdisciplinary scientific area</scie_area_en><scie_field_hr>Biotehnologija u biomedicini, </scie_field_hr><scie_field_en>Biotechnology in Biomedicine, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Fakultet biotehnologije i razvoja lijekova]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Biotechnology and Drug Development]]></institution_en><team_members_id>865075</team_members_id><team_members_names><![CDATA[ Doktorand: Robert Kolman ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>9434</id><title_hr><![CDATA[Bioaktivne molekule ljekovitog bilja kao prirodni antioksidansi, mikrobiocidi i konzervansi]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1002</user_id><user_firstLast_name>Ivona Elez Garofulić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-6665</code><acronim><![CDATA[]]></acronim><duration>19.10.2020 - 19.10.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Prehrambena tehnologija, </scie_field_hr><scie_field_en>Food technology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Food Technology and Biotechnology]]></institution_en><team_members_id>857308</team_members_id><team_members_names><![CDATA[ Doktorand: Erika Dobroslavić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>9435</id><title_hr><![CDATA[Hiperheurističko oblikovanje pravila raspoređivanja]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6984</user_id><user_firstLast_name>Domagoj Jakobović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-1040</code><acronim><![CDATA[HyDDRa]]></acronim><duration>01.10.2020 - 30.09.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>862768</team_members_id><team_members_names><![CDATA[ Doktorand: Lucija Planinić ]]></team_members_names><keywords_hr><![CDATA[raspoređivanje, heuristički algoritmi, hiperheuristike, evolucijsko računarstvo, genetičko programiranje]]></keywords_hr><keywords_en><![CDATA[scheduling, heuristic algorithms, hyperheuristics, evolutionary computation, genetic programming]]></keywords_en><summary_hr><![CDATA[Raspoređivanje je proces u kojemu je određeni skup poslova (aktivnosti) potrebno dodijeliti ograničenom skupu strojeva (sredstava), s ciljem optimiranja korisnički definiranih kriterija i zahtjeva. Zbog svoje složenosti većina problema raspoređivanja ne može se riješiti egzaktno, već se za njihovo rješavanje koriste različiti heuristički i metaheuristički postupci. Posebice veliki problem predstavljaju dinamički problemi raspoređivanja, kod kojih informacije o problemu (dolazak poslova u sustav, trajanja izvođenja poslova, kvarovi strojeva), nisu poznate unaprijed, već postaju poznate tijekom rada sustava. Umjesto ručnog definiranja prilagođenih algoritama raspoređivanja za različite kombinacije oganičenja i kriterija, hiperheurističkim postupcima moguće je automatski oblikovati postupak raspoređivanja za zadani problem. Hiperheuristički postupci su optimizacijske metode koje ne pronalaze rješenje zadanog problema, već optimiraju postupak rješavanja problema; najpoznatiji primjeri hiperheuristika su genetičko programiranje i inačice evolucijskih algoritama.Ovaj je projekt usmjeren na primjene različitih hiperheurističkih metoda s ciljem izrade pravila raspoređivanja za dinamičke probleme raspoređivanja koje nisu iscrpno proučene u literaturi. U ovom projektnom prijedlogu fokus je stavljen na okruženje nesrodnih strojeva i njegove varijante. Projektni prijedlog obuhvaća nekoliko smjerova istraživanja kojima je cilj poboljšanje kvalitete hiperheuristika u oblikovanju pravila raspoređivanja. Također, jedan od ciljeva projekta je i proširenje ove paradigme na srodne optimizacijske probleme, kao što su raspoređivanje uz ograničenja sredstava te usmjeravanje vozila. Projektni tim posjeduje potrebno iskustvo u primjeni hiperheurističkih i optimizacijskih postupaka te objavljene preliminarne rezultate koji upućuju na isplativost daljnjeg istraživanja u opisanom području.]]></summary_hr><summary_en><![CDATA[Scheduling is a process in which a certain set of tasks (activities) need to be assigned to a limited set of machines (resources) to optimize user-defined criteria and requirements. Because of its complexity, most of the scheduling problems cannot be solved exactly, but different heuristic and metaheuristic procedures are used for their solution. A particularly big challenge is dynamic scheduling, where information about the problem (job release dates, processing time, machine failures) is not known in advance but becomes known during system operation. Instead of manually defining customized scheduling algorithms for different combinations of constraints and criteria, hyperheuristic procedures can automatically form the scheduling algorithm for a given problem. Hyperheuristic procedures are optimization methods that do not find the solution to the problem, but optimize the problem-solving algorithm; the most common examples of hyperheuristics are genetic programming and variants of evolutionary algorithms. This project focuses on the application of various hyperheuristic methods with the aim of developing dispatching rules for dynamic scheduling problems that have not been thoroughly studied in the literature. In this project proposal, the focus is placed on the unrelated machines scheduling environment and its variants. The project proposal encompasses several research directions aimed at improving the quality of hyperheuristics in automatic developing of the dispatching rules. Additionally, one of the project&#39;s goals is to extend this paradigm to related optimization problems, such as scheduling with resource constraints and vehicle routing. The project team possesses the necessary experience in applying hyperheuristics and optimization methods and has published preliminary results indicating the viability of further research in this area.]]></summary_en></project><project>
<id>9436</id><title_hr><![CDATA[Erozija i degradacija tala Hrvatske]]></title_hr><title_en><![CDATA[]]></title_en><user_id>20011</user_id><user_firstLast_name>Igor Bogunović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-3645</code><acronim><![CDATA[SEDCRO]]></acronim><duration>14.09.2020 - 13.09.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Agronomski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Agriculture]]></institution_en><team_members_id>855969</team_members_id><team_members_names><![CDATA[ Doktorand: Ivan Dugan ]]></team_members_names><keywords_hr><![CDATA[erozija tla vodom, degradacija tala, vinogradi, klimatske promjene, voćnjaci]]></keywords_hr><keywords_en><![CDATA[soil water erosion, soil degradation, vineyards, climate changes, orchards]]></keywords_en><summary_hr><![CDATA[Degradacija tla je glavni okolišni problem u svijetu i ključno je da takvi procesi budu ublaženi. Potreba da se smanji utjecaj poljoprivrednih aktivnosti na okoliš i kontrolira degradacija strukture tala je jedan od glavnih ciljeva gospodarenja tlima. Različite strategije su razvijene radi smanjenja najvažnijeg degradacijskog problema – erozije tla. Međutim, poljoprivreda je još uvijek izvor najviše sedimenata u površinskim otjecajnim vodama. Danas, mnoštvo razloga pokreće neprihvatljivo gospodarenje tlima na poljoprivrednim tlima RH. Usprkos važnosti teme istraživanja o degradaciji tala na poljoprivrednim tlima u RH nedostaju. Mehanizmi, procesi, proporcije i kontrola erozije tla bili su istraživani u „Zapadnim“ državama više od stoljeća, ali je nadopuna potrebna radi prenošenja novih saznanja i rasprave o novim izazovima. U RH takva istraživanja nedostaju što otvara mnoga pitanja tijekom svakodnevnih klimatskih ekstrema. Klimatske promjene povećavaju broj olujnih kiša. Takve oluje su uzrok netolerantnih erozijskih nanosa s razarajućim posljedicama po okoliš. Istraživanje erozije i degradacije tla na tlima u RH mogu pružiti detaljan uvid za razumijevanje procesa degradacije tala. Trenutna tema istraživanja može otkriti najugroženija tla i najlošije načine korištenja istih. Glavni faktori koji određuju gubitak tla erozijom i površinskim otjecanjem biti će ocjenjeni.Ovaj projekt predlaže kompletni pregled tla, korištenja zemljišta u drugačijim klimatskim uvjetima u Hrvatskoj koji se bave problemom erozije tla vodom. Baza podataka iz 5-godišnjeg istraživanja (s više od 40 lokacija) biti će jedan od najkompletnijih aktualnih baza za proučavanje utjecaja uzročnih čimbenika na eroziju tla vodom. ]]></summary_hr><summary_en><![CDATA[Soil degradation is a major environmental problem worldwide and is crucial that such processes must be mitigated. The need to reduce the environmental impact of agricultural activities and to control soil structure degradation is one of the main aims of land management. Strategies have been developed to reduce the most important degradation problem- soil erosion. However, agriculture is still the source of most sediments in surface runoff waters. Nowadays, complex of reasons are driving forces for unsustainable soil management practices in Croatian agricultural land. Despite the relevance of the topic there is lack of research on soil degradation on Croatian agricultural soils. The mechanisms, processes, rates and control of soil erosion have been scientifically studied in Western countries, but an update was needed to convey new findings and discuss new challenges. In Croatia, such research is missing which especially open the new dilemma during every-day climatic extremes. Climate changes increase a numbers of high rainfall intensity events. Such events triggered intolerant soil erosion rates with devastating consequences to environment.Research of soil erosion and degradation on Croatian soils can provide deep insight for understanding the processes of soil degradation. Present subject can help to discover most endanger soils and unsustainable land use practices. This project will quantify water and soil losses in Croatian agricultural soils under high intensity rainfall simulation on the soils under several land use and management strategies. The main factors that determine soil losses and runoff will be assessed.This project proposed an overview of soils, land use, and climatic conditions in Croatia that deal with the problem of soil water erosion. Dataset derived from 5 years research (from more than 40 locations) will be one of the most complete and up to-date databases for studying the effect of triggering factors on soil water erosion. ]]></summary_en></project><project>
<id>9438</id><title_hr><![CDATA[Potencijalne terapijske biomolekule druge generacije probiotika]]></title_hr><title_en><![CDATA[]]></title_en><user_id>797</user_id><user_firstLast_name>Andreja Leboš Pavunc</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-6663</code><acronim><![CDATA[PRO-BIO 2.0]]></acronim><duration>19.10.2020 - 18.01.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Biotehnologija, </scie_field_hr><scie_field_en>Biotechnology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Food Technology and Biotechnology]]></institution_en><team_members_id>858323</team_members_id><team_members_names><![CDATA[ Doktorand: Nina Čuljak ]]></team_members_names><keywords_hr><![CDATA[biomolekule, egzopolisaharidi, intestinalna mikrobiota, mikrobiom, nanoinkapsulacija, probiotici, S-proteini]]></keywords_hr><keywords_en><![CDATA[biomolecules, exopolysaccharides, intestinal microbiota, microbiome, nanoencapsulation, probiotics, S-proteins]]></keywords_en><summary_hr><![CDATA[Najnovija istraživanja druge generacije probiotika usmjerena su na njihovu terapijsku primjenu kao „živih lijekova”, nazvanih od strane US FDA „živi bioterapijski pripravci“. Naime, promjene u sastavu crijevne mikrobiote su ustanovljene kod različitih metaboličkih poremećaja i bolesti, a ključnu ulogu u uspostavljanju ravnoteže crijevne mikrobiote imaju prvi dani života, pri čemu mikrobiota majčinog mlijeka značajno utječe na sastav crijevne mikrobiote dojenčeta. Stoga je glavni cilj istraživanja odabir i funkcionalna karakterizacija probiotičkih sojeva bakterija mliječne kiseline (BMK), izoliranih iz uzoraka majčinog mlijeka, a koje proizvode molekule s potencijalnim terapijskim djelovanjem, egzopolisaharide (EPS) i površinske S-proteine, što je svojstvo samo rijetkih sojeva BMK. Bit će provedena komparativna  analiza sekvencioniranih genoma odabranih sojeva BMK te izolacija, purifikacija i karakterizacija potencijalnih terapijskih biomolekula, primjenom LC/MS, MALDI-TOF i NMR analiza. Potencijal odabranih probiotičkih sojeva BMK, i njihovih specifičnih biomolekula, u adheziji, kolonizaciji, kompetitivnoj ekskluziji patogena, imunomodulaciji, regeneraciji sluznice crijeva i utjecaju na sastav mikrobiote u gastrointestinalnom traktu (GIT-u) će biti istražen na in vitro, ex vivo i in vivo eksperimentalnim modelima simuliranog GIT-a, Caco-2 crijevnih epitelnih stanica, primarne stanične kulture humanih kolonocita s izazvanim upalnim procesom i eksperimentalnih miševa kojima će biti izazvana upalna bolest crijeva. Okarakterizirani sojevi BMK i njihove izolirane i purificirane funkcionalne biomolekule s potencijalnim terapijskim djelovanjem, biti će proizvedeni kao nano- i mikro-inkapsulirani, liofilizacijom osušeni pripravci. Bit će provedeno optimiranje sastava protektivnih matriksa za inkapsulaciju u svrhu postizanja zaštitnog učinka tijekom proizvodnje i oralne primjene, te boljeg preživljavanja i probiotičke aktivnosti sojeva BMK na ciljnom mjestu djelovanja.]]></summary_hr><summary_en><![CDATA[The next generation probiotic investigations are focused on their therapeutic use as &#39;&#39;living drugs&#39;&#39;, which are entitled &#39;&#39;Live Biotherapeutic Products&#39;&#39; by US FDA. Namely, the altered intestinal microbiota composition has been associated with various metabolic disorders, and the establishing of the intestinal microbiota balance in the earliest days of life is crucial, since breast milk microbiota is significantly affecting the composition of the infant intestinal microbiota. Therefore, the aim of this research is selection and functional characterization of probiotic lactic acid bacteria (LAB), isolated from mother&#39;s milk, with a capacity to synthesize biomolecules with potential therapeutic activity, exopolysaccharides (EPS) and surface S-proteins, which are produced by sparse LAB strains. Besides comparative genome analysis of the selected LAB, purification and characterization of promising therapeutic biomolecules will be performed by LC/MS, MALDI-TOF and NMR analysis. The potential of selected and characterised LAB strains and their specific biomolecules in the adhesion, colonisation, competitive exclusion, immunomodulation, regeneration of intestinal barrier function and the impact of the intestinal microbiota composition will be investigated by in vitro, ex vivo and in vivo experimental models demonstrated through application of Caco-2 intestinal epithelial cells, human colonocytes in primary cell culture with induced inflammation and on experimental chemically induced murine models of inflammatory bowel disease. Well-characterized LAB strains and their isolated and purified functional biomolecules with potential therapeutic activity will be produced as nano- and micro-encapsulated, freeze-dried preparations. The composition of protective matrices for encapsulation will be optimised in order to achieve protective effect during production and oral delivery, and to improve survival and probiotic activity of LAB strains in situ.]]></summary_en></project><project>
<id>9439</id><title_hr><![CDATA[Molekularno krojenje istezljivih i zacijeljivih vodljivih polimera za nosivu elektroniku]]></title_hr><title_en><![CDATA[]]></title_en><user_id>973</user_id><user_firstLast_name>Zvonimir Katančić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-5064</code><acronim><![CDATA[SHaPes]]></acronim><duration>27.10.2020 - 25.01.2025</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Kemijsko inženjerstvo, </scie_field_hr><scie_field_en>Chemical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet kemijskog inženjerstva i tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Chemical Engineering and Technology]]></institution_en><team_members_id>858331</team_members_id><team_members_names><![CDATA[ Doktorand: Marin Božičević ]]></team_members_names><keywords_hr><![CDATA[Molekularno krojenje, Nosiva elektronika, Samozacjeljivanje, Istezljivi elektrovodljivi polimeri, Radikalska polimerizacija prijenosom atoma (ATRP)]]></keywords_hr><keywords_en><![CDATA[Molecular tailoring, Wearable electronics, Self-healing, Stretchable conductive polymers, Atom transfer radical polymerization (ATRP)]]></keywords_en><summary_hr><![CDATA[Nove granice u organskoj elektronici su nosive elektronike od vodljivih polimernih materijala s visokim električnim i nalik-koži svojstvima. Takvi materijali imaju sposobnost istezanja i kretanja zajedno s ljudskim tijelom što otvara mogućnosti za razvoj istezljivih senzora za kontinuirano praćenje zdravlja. Ključno je krojenje molekularnog dizajna kako bi se dobili funkcionalni materijali koji se mogu istegnuti i zacijeliti nakon mehaničkih oštećenja. Trenutni molekularni dizajn vodljivih polimera ne može učiniti materijal istodobno rastezljivim i mehanički stabilnim uz zadržavanje sposobnosti visoke vodljivosti.Glavni cilj SHaPes-a je popuniti prazninu u znanju o novom konceptu dizajna kako bi se odgovorilo na navedeni izazov razvojem intrinzično rastezljivih i zacijeljivih vodljivih materijala koji će biti spremni za slaganje senzora za praćenje zdravlja.Ovdje predlažemo dva pristupa uvođenjem kemijskih skupina putem molekularnog krojenja za a) dinamičko nekovalentno umrežavanje i b) kovalentno umrežavanje konjugiranih graft kopolimera. Graft kopolimeri će se temeljiti na poli(3,4-etilendioksitiofenu) kao glavnom lancu i poli(akril-uretanu), te polietilen glikolu ili polikaprolaktonu kao bočnim lancima. Za postizanje postavljenog cilja koristit će se radikalska polimerizacija prijenosom atoma, kontrolirana radikalska polimerizacija kojom je moguće sintetizirati graft kopolimer s kontroliranom gustoćom i duljinom bočnih lanaca odgovornih za rastezljivost i zacijeljivost. Sintetizirani polimeri biti će inkjet tiskani na elastične podloge kako bi se dobio materijal spreman za integraciju senzora.Relevantnost i potencijalna korist SHaPes-a je razvoj znanstvene infrastrukture koja će doprinijeti modernizaciji hrvatske znanosti i tehnologije, te uključiti Hrvatsku u globalni napor za razvoj materijala sljedeće generacije za  izradu novih elektroničkih uređaja kao proizvoda visoke dodane vrijednosti.]]></summary_hr><summary_en><![CDATA[New frontiers in organic electronics are wearable electronics made of conductive polymer materials with high electrical performance and skin-like properties. Such materials have the ability to stretch and move together with the human body which opens opportunities for development of stretchable sensor for continuous health monitoring. The key is the tailoring of molecular design to obtain functional materials that can stretch and repair themselves after mechanical damage. Current molecular design of conductive polymers is unable to render material simultaneously stretchable, mechanically stable while retaining its high charge transport ability. The main goal of SHaPes is to fill the knowledge gap on new design concept to address the above challenge by developing intrinsically stretchable and healable conductive materials that will be ready for assembly of health monitoring sensors.  Herein, we propose two approaches by introducing chemical moieties through molecular tailoring to promote; a) dynamic non-covalent crosslinking and b) covalent crosslinking of the conjugated graft polymers. The graft copolymers will be based on poly(3,4-ethyilenedioxythiophene) as the backbone and poly(acrylate urethane), and polyethylene glycol or polycaprolactone as the side chains. To achieve the set goal atom transfer radical polymerization, a controlled radical polymerization able to create graft copolymer with controlled density and length of the side chains responsible for stretchability and healability, is going to be utilized. Synthesized polymers will be inkjet printed to elastic substrates to obtain material ready for sensor integration.Relevance and potential benefit of SHaPes is the development of scientific infrastructure that will contribute to modernization of Croatian science and technology and include Croatia into global effort for developing next-generation materials for fabrication of new electronic devices as products of high added value.]]></summary_en></project><project>
<id>9440</id><title_hr><![CDATA[WINTER MED - Winter Islands Network for all year round Tourism ExpeRience in the MEDiterranean]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6119</user_id><user_firstLast_name>Kristina Brščić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-4260</code><acronim><![CDATA[]]></acronim><duration>27.07.2020 - 27.07.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, </scie_field_hr><scie_field_en>Economy, </scie_field_en><institution_hr><![CDATA[Institut za poljoprivredu i turizam]]></institution_hr><institution_en><![CDATA[Institute of Agriculture and Tourism in Poreč]]></institution_en><team_members_id>25993</team_members_id><team_members_names><![CDATA[ Doktorand: Katarina Lovrečić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>9441</id><title_hr><![CDATA[Pametna platforma za daljinska istraživanja u okolišu i industriji primjenom milimetarskih valova]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6893</user_id><user_firstLast_name>Marko Bosiljevac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-3556</code><acronim><![CDATA[MMSENSE]]></acronim><duration>01.10.2020 - 01.07.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>856246</team_members_id><team_members_names><![CDATA[ Doktorand: Filip Turčinović ]]></team_members_names><keywords_hr><![CDATA[sustavi za daljinska istraživanja, milimetarski elektromagnetski valovi, nadzor okoliša, klasifikacija objekata, primijenjeno strojno učenje]]></keywords_hr><keywords_en><![CDATA[remote sensing systems, millimeter electromagnetic waves, environment sensing, object classification, applied machine learning]]></keywords_en><summary_hr><![CDATA[Daljinska istraživanja primijenjena u okolišu i industriji temeljena na multispektralnom ili radarskom snimanju danas imaju važnu ulogu u osiguravanju održivosti i zaštiti prirodnih resursa, uštedi vremena i energije u industriji i poljoprivredi te u mnogim drugim primjenama. Postoje brojni primjeri takvih sustava koji pružaju informacije poput kvalitete proizvoda proizvođačima, parametara rasta usjeva poljoprivrednicima ili detalje strukturalnog integriteta građevinskim inženjerima. Zahvaljujući napretku u razvoju tehnologije u području elektromagnetskih milimetarskih valova (mm-valova), u brzoj obradi signala i primjeni umjetne inteligencije, primjena daljinskih istraživanja kratkog dometa koja koriste mm-valove ima snažan rast pri čemu tržište diktira nove primjene sa sve većom razinom autonomije sustava.Cilj ovog projekta je istražiti i realizirati metodologije, algoritme i sklopovske koncepte koji će zadovoljiti zahtjeve novih primjena u smislu poboljšane autonomije, pristupačne cijene, energetske učinkovitosti i unaprijeđenja komunikacijskih mogućnosti. Specifični ciljevi koji će se postići su; (i) učinkovita klasifikacija objekata primjenom nadziranog strojnog učenja na temelju informacija o radarskom raspršenju mm-valova, (ii) poboljšani algoritmi obrade i kompresije signala u radarima za daljinska istraživanja koji koriste mm-valove, (iii) razvoj antenskog niza s pametnom kontrolom skeniranja zrake, i (iv) optimizacija komunikacijskog protokola za prijenos velikih količina podataka dobivenih daljinskim istraživanjem. Konačni cilj je demonstrirati razvijene tehnike na pametnoj platformi za daljinska istraživanja zasnovanoj na mm-valovima koja bi se mogla koristiti u raznim ekološkim ili industrijskim područjima i lako integrirati s drugim senzorima u mrežama Interneta stvari. Osim toga, ovo će istraživanje značajno unaprijediti razinu stručnosti naše grupe, a posebno mladih istraživača uključenih kroz diplomske i doktorske studije.]]></summary_hr><summary_en><![CDATA[Remote environmental and industrial sensing based on multi-spectral or radar imaging today plays an important role in ensuring sustainability and protection of natural resources, in saving time and energy in industry and agriculture, and in many other applications. Numerous examples of such systems exist which provide information like product quality to manufacturers, crops growth parameters to farmers or structural integrity details to civil engineers. With recent developments in electromagnetic millimeter-wave (mm-wave) technology, high-speed signal processing and artificial intelligence implementation, short range mm-wave remote sensing is experiencing strong growth with the market dictating new applications with increasingly higher levels of system autonomy. The objective of this project is to investigate and realize methodologies, algorithms and hardware concepts that will meet the demands of these new applications in terms of improved autonomy, reasonable cost, energy efficiency and improved communication possibilities. The specific goals that will be achieved are; (i) efficient supervised machine learning classification of objects based on mm-wave radar scattering information, (ii) improved signal processing and compressing algorithms for mm-wave remote sensing radars, (iii) development of antenna array with smart control of beam scanning, and (iv) optimization of communication protocol for transmission of large quantities of data obtained by remote sensing. The final goal is to demonstrate developed principles on a smart mm-wave remote sensing platform that could be used in various environmental or industrial fields and easily integrated with other sensors in Internet-of-Things networks. Additionally, this research will significantly advance the level of expertise of our group and in particular of the young researchers involved through Master and PhD studies.]]></summary_en></project><project>
<id>9444</id><title_hr><![CDATA[Razumijevanje (eko)toksikološke uloge odabranih SLC i MATE transportnih proteina zebrice (Danio rerio) korištenjem metoda funkcionalne genomike]]></title_hr><title_en><![CDATA[]]></title_en><user_id>986</user_id><user_firstLast_name>Tvrtko Smital</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-3081</code><acronim><![CDATA[DANIOTRANS]]></acronim><duration>23.03.2021 - 22.09.2025</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>865289</team_members_id><team_members_names><![CDATA[ Doktorand: Lana Vujica ]]></team_members_names><keywords_hr><![CDATA[uptake i efflux membranski transportni proteini, (eko)toksikološka relevantnost, zebrica (Danio rerio), funkcionalna genomika, CRISPR/Cas9]]></keywords_hr><keywords_en><![CDATA[uptake and efflux membrane transporters, (eco)toxicological relevance, zebrafish (Danio rerio), functional genomics, CRISPR/Cas9]]></keywords_en><summary_hr><![CDATA[Polispecifični membranski transportni proteini predstavljaju integralni dio kompleksne stanične obrane u sisavaca, a dva tipa transportera pri tome su od osobite toksikološke važnosti: tzv. uptake transporteri i efflux transporteri. Analogni stanični obrambeni sustav uključen je u procesiranje endo- i ksenobiotika i u vodenih organizama. Nedavna istraživanja naše i drugih istraživačkih skupina pokazala su da procesiranje ksenobiotika u vodenih organizama uključuje regulaciju njihove apsorpcije putem SLC (solute carriers) uptake transportera organskih aniona i kationa, nakon čega slijedi njihova biotransformacija posredovana detoksikacijskim enzimima faze I. i II. Nastali metaboliti, a u nekim slučajevima i originalni spojevi, potom se aktivno izbacuju iz stanica posredstvom tzv. ABC (ATP binding cassette) transportera. Osim toga, pokazali smo i da je nedavno otkrivena grupa efflux transportera, tzv. MATE (multidrug and toxic compound extrusion) proteina, prisutna i aktivna u ribi zebrici (Danio rerio). Oslanjajući se naša nedavna istraživanja uptake i efflux transportera, u ovom projektu namjeravamo značajno unaprijediti naše razumijevanje (eko)toksikološke uloge odabranih SLC i MATE proteina koristeći se oruđima funkcionalne genomike zebrice. Ukratko, u projektu ćemo: (1) koristiti zebricu kao etabliran istraživački model kralješnjaka; (2) fokusirati se na uptake i efflux transportere nedavno karakterizirane in vitro (Oatp1d1, Oat1/3, Oct1, Mate7), s dodatkom transportera koji nisu bili analizirani u našim prijašnjim in vitro istraživanjima (Oatp2b1, Mates3 and 8); i (3) pokušat ćemo otkriti fiziološku i/ili obrambenu ulogu odabranih transportera korištenjem CRISPR/Cas9 pristupa editiranja genoma za stvaranje prvih genetički modificiranih zebrica za odabrane transportere, koje ćemo potom koristiti za određivanje posljedičnih promjena fenotipa, odnosno toksikološkog odgovora tijekom izlaganja modelnim supstratima i inhibitorima, uključujući okolišna zagađivala. ]]></summary_hr><summary_en><![CDATA[Polyspecific transmembrane proteins are integral components of a highly complex cellular defense in mammalian cells, and the two types of transporters are of particular toxicological relevance: the so-called uptake transporters and the efflux transporters. Analogous cellular defense systems are involved in processing of endo- and xenobiotics in aquatic organisms. It has been demonstrated by our research group and the others that processing of xenobiotics in aquatic organisms includes regulation of their absorption by the SLC (solute carriers) uptake transporters of organic anions and cations, followed by biotransformation of xenobiotic substances mediated by the phase I and II enzymes. The resulting metabolites, and is some cases even original xenobiotic substances, are then actively pumped out of the cells by the ABC transporters. In addition, we showed that a more recently recognized class of efflux transporters, MATEs (multidrug and toxic compound extrusion proteins) are present and active in zebrafish (Danio rerio). Therefore, based on extensive research our group done recently working both on the uptake and efflux transporters, in this project we aim to significantly improve our understanding of the (eco)toxicological role of selected SLC and MATE transporters using zebrafish  functional genomics tools. In short, we will (1) use zebrafish as a well-established research model; (2) focus on uptake and efflux transporters recently characterized in vitro (Oatp1d1, Oat1/3, Oct1, Mate7), with addition of transporters not evaluated in vitro in our previous research (Oatp2b1, Mates3 and 8); and (3), will try to decipher physiological and/or defensive role of selected transporters using CRISPR/Cas9 based genome editing tools for generation of the first transporter(s) deficient zebrafish, followed by determinations of resulting phenotype changes, and toxicological endpoints upon exposure to model substrates and inhibitors, including environmental contaminants.  ]]></summary_en></project><project>
<id>9446</id><title_hr><![CDATA[Aerial-Core - AERIAL COgnitive integrated multi-task Robotic system with Extended operation range and safety]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5054</user_id><user_firstLast_name>Zdenko Kovačić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-9865</code><acronim><![CDATA[]]></acronim><duration>10.10.2020 - 09.04.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Temeljne tehničke znanosti, </scie_field_hr><scie_field_en>Basic engineering sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>856276</team_members_id><team_members_names><![CDATA[ Doktorand: Filip Zorić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>9447</id><title_hr><![CDATA[(Epi)genomika i transkriptomika eukromatinskih satelitnih DNA u embriogenezi i razvoju]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5779</user_id><user_firstLast_name>Nevenka Meštrović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-1590</code><acronim><![CDATA[EpiTranSat]]></acronim><duration>01.11.2020 - 30.04.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>858407</team_members_id><team_members_names><![CDATA[ Doktorand: Marin Volarić ]]></team_members_names><keywords_hr><![CDATA[Tribolium castaneum, ponovljene sekvence, satelitne DNA, nanopor sekvenciranje, slaganje genoma, funkcija, transkripcija, modulacija gena]]></keywords_hr><keywords_en><![CDATA[Tribolium castaneum, repetitive sequences, satellite DNA, nanopore sequencing, genome assembly, function, transcription, genes modulation]]></keywords_en><summary_hr><![CDATA[Satelitne DNA (satDNAs) su visoko zastupljene, uzastopno ponovljene, nekodirajuće DNA, uglavnom smještene u (peri)centromernom heterochromatinu koje imaju ključnu ulogu u centromernoj funkciji. Postoje dokazi da su ta područja aktivno transkribirana, a transkripti su uključeni u formiranje heterohromatina, stresu i malignoj transformaciji. Novije studije također pokazuju postojanje različitih satDNA i u eukromatinu mnogih vrsta, ali podaci o njihovoj biološkoj ulozi u potpunosti nedostaju. Naša prethodna studija na modelnom organizmu, kukca Tribolium castaneum pokazala je postojanje devet vrlo zastupljenih satDNA (Cast1-Cast9) koji se nalaze isključivo u eukromatinskim regijama. Iako su satDNA, Cast1-Cas9, nisko zastupljene u sekvenciranom referentnom genomu vrste T. castaneum, kvantitativna analiza otkrila je da ove satDNA predstavljaju značajan udio, čak 5% genoma. Naši neobjavljeni rezultati ukazuju na transkripcijski potencijal i epigenetski status ovih satDNA koji govore u prilog njihovoj &#39;&#39;eukromatičnoj&#39;&#39; prirodi. Njihova zastupljenost u genomu, transkripcijski potencijal i moguća distribucija u blizini gena čine eukromatinske satDNA privlačnim za istraživanje. Stoga, da bismo stekli uvid u evolucijske trendove i biološku važnost eukromatinskih satDNA kod vrste T. castaneum, dva glavna cilja projekta biti će: 1) otkriti evolucijsku dinamiku eukromatinskih satDNA te otkriti gene u blizini nizova satDNA, što ćemo postići sekvenciranjem genoma dugim očitanjima nanopora i slaganjem Cast1-Cast9 u referentni genom i 2) utvrđivanje njihove funkcionalna uloge, istraživanjem transkripcijskijskog potencijala, epigenetske regulacije i utjecaja na ekspresiju gena u blizini tijekom embriogeneze i razvoja. Vrsta T. castaneum predstavlja izniman model za postizanje predloženih ciljeva, jer ima anotiran genom, jasno definirane razvojne faze, temeljito istraženu embriogenezu i razvojne faze mozga te tako omogućuje funkcionalnu procjenu transkriptoma eukromatinskih satDNA.]]></summary_hr><summary_en><![CDATA[Satellite DNAs (satDNAs) are abundant tandemly repeated, non-coding DNAs largely located in (peri)centromeric heterochromatin which have an essential role in centromere function. There are evidences that these regions are actively transcribed, and transcripts are engaged in heterochromatin formation, stress and malignant transformation. However, recent data revealed the existence of different satDNAs in euchromatin of many species but information on their biological role is completely missing. In the beetle model Tribolium castaneum we previously identified nine abundant satDNAs (Cast1-Cast9) located exclusively in euchromatic regions. Although Cast1-Cas9 satDNAs are strongly underrepresented in T. castaneum reference genome, quantitative analysis disclosed that these satDNAs comprise significant 5% of the genome. Our unpublished results indicate transcription potential and epigenetic status which speak in favour of their “euchromatic” nature. Genome abundance, their transcription potential and putative distribution in the vicinity of genes make euchromatic satDNAs attractive for investigation. To gain insight into evolutionary trends and the biological relevance of euchromatic satDNAs in T. castaneum two main goals will be addressed: 1) to discover the evolutionary dynamics of euchromatic satDNAs and detect genes in the vicinity of satDNA arrays, we will sequence the genome using a long read nanopore approach and Cast1-Cast9 will be assembled in the reference genome, and 2) to reveal their functional role, we will investigate their transcription potential, epigenetic regulation and possible impact on expression of genes in the vicinity during embryogenesis and development. T. castaneum represents an excellent model to achieve the proposed aims because it has annotated genome, clearly defined developmental stages, thoroughly explored embryogenesis and brain development which enable functional evaluation of the euchromatic satDNA transcriptome.]]></summary_en></project><project>
<id>9448</id><title_hr><![CDATA[Robotska percepcija stvarnog svijeta: razumijevanje složenih scena]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6310</user_id><user_firstLast_name>Robert Cupec</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-7140</code><acronim><![CDATA[COSPER]]></acronim><duration>22.10.2020 - 21.10.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera Osijek, Fakultet elektrotehnike, računarstva i informacijskih tehnologija Osijek]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Electrical Engineering, Computer Science and Information Technology Osijek]]></institution_en><team_members_id>862760</team_members_id><team_members_names><![CDATA[ Doktorand: Matej Džijan Džijan ]]></team_members_names><keywords_hr><![CDATA[robotika, računalni vid, prepoznavanje objekata, razumijevanje slike, učenje robota od strane čovjeka]]></keywords_hr><keywords_en><![CDATA[robotics, computer vision, object recognition, image understanding, robot training by human instructor]]></keywords_en><summary_hr><![CDATA[Sposobnost prepoznavanja objekata od interesa u složenim scenama te identificiranja njihovih dijelova relevantnih za rješavanje određenog zadatka predstavlja jednu od osnovnih funkcionalnosti inteligentnih robota namijenjenih radu u stvarnom svijetu. Mada je prepoznavanje objekata poznatog oblika dobro istražen problem za koji su ponuđena mnoga rješenja, prepoznavanje prvi put viđenih pripadnika određene prethodno naučene klase objekata na složenim scenama još je uvijek izazovan problem. Pored same detekcije objekata od interesa, za robotiku je od posebnog interesa identifikacija dijelova objekata relevantnih za obavljanje određenih zadataka. U predloženom projektu istraživat će se prepoznavanje objekata od interesa i njihovih dijelova na složenim scenama s ciljem razvoja novih kompetitivnih pristupa. Osim prepoznavanja objekata koji predstavljaju kruta tijela, razvijat će se i algoritmi za prepoznavanje artikuliranih objekata, tj. objekata sastavljenih od više krutih tijela povezanih gibljivim zglobovima, kao što su ormarići s ladicama, prozori, vrata, roboti itd., te estimacije njihovih kinematičkih parametara. Istraživat će se mogućnost prenošenja naučenog znanja o mogućnostima promjene konfiguracije artikuliranih objekata na druge pripadnike iste klase objekata. Također će se istraživati i strategije aktivnog vida, koje omogućuju povećanje uspješnosti prepoznavanja objekata odgovarajućim pozicioniranjem kamere montirane na robotski manipulator te interakcijom robota i objekta prepoznavanja. Treća tema predloženog projekta je učenje robota da obavlja neku radnju kroz demonstraciju od strane čovjeka. Razvijat će se metode koje omogućuju prilagodbu naučene radnje na različite objekte i različite situacije. Za rješavanje navedenih problema, koristit će se neuronske mreže i metodologija zasnovana na poliedarskim modelima klasa oblika, razvijena u okviru prethodnog projekta implementiranog od strane prijavitelja ovog projekta i njegovog istraživačkog tima. ]]></summary_hr><summary_en><![CDATA[Ability to recognize objects of interest in complex scenes as well as to identify their parts relevant for solving a particular task is one of the basic functionalities of intelligent robots designed to operate in the real world. Although recognition of objects of known and rigid shape is a thoroughly studied problem, for which a number of solutions are proposed, recognition of previously unseen objects, which are members of previously learned object classes, in complex scenes is still a challenging problem. Besides detection of objects of interest, a subject of special importance for robotics is identification of object parts relevant for solving a particular task. In the proposed project, recognition of objects of interest and their parts in complex scenes will be addressed, with the aim of developing novel competitive approaches. The second research topic of the project is development of novel methods for recognition of articulated objects, i.e. objects built from several rigid bodies connected by movable joints, such as drawers, doors, windows, robots etc., and estimation of their kinematic parameters. We will investigate possibilities of transferring learned knowledge about changing configurations of articulated objects from few representatives to other members of the same object class. Furthermore, active vision strategies will be studied, aimed at improving the object recognition performance by optimal positioning of the camera mounted on a robot arm and interaction between the robot and the target object. The third topic of the proposed project is training a robot to perform certain actions by demonstration performed by a human instructor. We will develop methods which allow adaptation of a learned action to different objects and different situations. For solving the addressed problems, we will use neural networks and the methodology based on polyhedral shape class model, developed in a previously implemented project of the applicant.]]></summary_en></project><project>
<id>9449</id><title_hr><![CDATA[Science and Technology in childhood Obesity Policy - STOP ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1126</user_id><user_firstLast_name>Maroje Sorić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-3728</code><acronim><![CDATA[]]></acronim><duration>01.11.2020 - 31.10.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Javno zdravstvo i zdravstvena zaštita, </scie_field_hr><scie_field_en>Public health and health services, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Kineziološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Kinesiology]]></institution_en><team_members_id>861742</team_members_id><team_members_names><![CDATA[ Doktorand: Antonio Martinko ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>9451</id><title_hr><![CDATA[Sekundarno omatanje i izlazak beta-herpesvirusa iz stanice]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6604</user_id><user_firstLast_name>Pero Lučin</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-3952</code><acronim><![CDATA[AsCoSE&E]]></acronim><duration>01.10.2020 - 30.05.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Medicine]]></institution_en><team_members_id>861733</team_members_id><team_members_names><![CDATA[ Doktorand: Ivona Viduka ]]></team_members_names><keywords_hr><![CDATA[beta-herpesvirus, citomegalovirus, odjeljak za sklapanje viriona, sekundarno omatanje viriona, izlazak virusa]]></keywords_hr><keywords_en><![CDATA[beta-herpesvirus, cytomegalovirsu, assembly compartment, secondary envelopment, virion egress]]></keywords_en><summary_hr><![CDATA[Beta-herpesvirusi opsežno reorganiziraju membranski sustav stanice domaćina i iskorištavaju ga za završne faze u proizvodnji virusa: stjecanje virusne ovojnice i izlazak virusa iz stanice. Mjesto i mehanizmi tih procesa su nejasni zbog nedovoljno razjašnjene složenosti membranskog sustava, nedovoljno razvijenih metoda za kvantifikaciju otpuštenih viriona, te nemogućnosti praćenja pojedinačnog virusa i/ili organele unutar stanice. U ovom projektu koristiti ćemo rekombinante mišjeg citomegalovirusa (MCMV), člana beta-herpesvirus obitelji, za poboljšanje metoda kvantifikacije izvanstaničnih viriona, razlikovanje virusne replikacije od proizvodnje virusa te unutarstanično praćenja virusa. Rekombinantni MCMV s fluorescentno-obilježenim malim kapsidnim proteinom, jedini raspoloživi virusi s označenom kapsidom u obitelji beta-herpesvirusa, omogućit će analizu kolokalizacije i dinamičko praćenje virusa tijekom procesa stjecanja ovojnice. S obzirom na to da je izlazak CMV iz stanice rijedak događaj, koristit ćemo digitalnu holotomografsku mikroskopiju (DHTM) kako bismo pratili izlazak MCMV-a iz stanice i razvili test za proučavanje procesa izlaska. Korištenjem sustavnih pristupa, kao što su analiza lokalnog interaktoma pomoću računalnih metoda i BioID testa (proximity-dependent biotin-identification assay), analiza transcriptoma i linearnih motiva u virusnim proteinima, usredotočit ćemo se na značajne stanične čimbenike koji kontroliraju procese virusnog omatanja i izlaska. Značajne čimbenike testirat ćemo pomoću novorazvijenih metoda za  siRNA skrining u dva koraka te identificirati one koji su neophodni za završne faze sazrijevanja virusa. Kako bi stekli mehanicistički uvid, pomoću poboljšane metodologije i knock-down metodama (siRNA) u zaraženim stanicama, dubinski ćemo analizirati male GTPaze iz obitelji Rab i/ili Arf koje kontroliraju svaki od tih procesa.]]></summary_hr><summary_en><![CDATA[Beta-herpesviruses extensively reorganize the membranous system of the host cell which is exploited for the final stages of virus manufacturing, the secondary envelopment and virion egress. The site and mechanisms of these processes remain unresolved due to the unrevealed complexity of the membranous system, insufficiently developed methods for quantification of released virions, and inability of single virus- and/or organelle-tracking inside the cell. In this project we will use recombinants of the murine cytomegalovirus (MCMV), a member of the beta-herpesvirus family, to improve methods of extracellular virus quantification, distinguishing virus replication from production, and virus tracking. Recombinant MCMVs with fluorescently tagged small capsid protein (SCP), the only available capsid-tagged viruses in the beta-herpesvirus family, will enable colocalization analysis and time-lapse tracking during processes of the secondary envelopment. Given that the CMV egress is a rare event we will use digital holotomographic microscopy (DHTM) to track MCMV egress and to develop an assay for egress monitoring. Using systems approaches, such as analysis of local interactome using computational methods and proximity-dependent biotin identification assay, analysis of transcriptome and linear motif mimicry, we will focus to significant host-cell factors that control the processes of envelopment and egress. The significant host-cell factors will be screened using the newly developed two-step siRNA screening assays and those that are essential for the final stages will be identified. To gain mechanistic insights, a small GTPase from Rab and/or Arf family that controls each of these processes will be analyzed in-depth using the improved methodology and knock-down in infected cells. The data obtained will serve for construction of the roadmap of cellular changes required for the final stages of beta-herpesvirus maturation and for identification of potential antiviral targets.]]></summary_en></project><project>
<id>9455</id><title_hr><![CDATA[Kulturni krajolik – model valorizacije, zaštite, upravljanja i korištenja kulturne baštine]]></title_hr><title_en><![CDATA[]]></title_en><user_id>22523</user_id><user_firstLast_name>Igor Kulenović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-4634</code><acronim><![CDATA[ProHeritage]]></acronim><duration>16.12.2020 - 15.12.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Arheologija, </scie_field_hr><scie_field_en>Archeology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zadru]]></institution_hr><institution_en><![CDATA[University of Zadar]]></institution_en><team_members_id>861527</team_members_id><team_members_names><![CDATA[ Doktorand: Sara Iglić ]]></team_members_names><keywords_hr><![CDATA[kulturna baština, kulturni krajolik, karakterizacija povijesnog krajolika, GIS, valorizacija, zaštita, upravljanje]]></keywords_hr><keywords_en><![CDATA[cultural heritage, cultural landscape, HLC, valorisation, protection, management]]></keywords_en><summary_hr><![CDATA[Arheologija je u posljednjih 20-ak godina doživjela nekoliko transformacija. Osim epistemoloških i teorijskih zaokreta arheologiju su oblikovale nove tehnologije i novi mediji koji su stvorili nove perspektive i područja rada. Jedna od najvećih transformacija koja se je dogodila u arheologiji je razvoj arheologije krajolika. Ovaj zaokret su popratile i različite legislative od kojih je najznačajnija Europska konvencija o krajoliku (Firenca 2000.). Sukladno tome su razvijene metode i procedure valorizacije, zaštite i upravljanja baštinom na temelju krajolika. Cilj ovog projekta je razviti hrvatski model valorizacije, zaštite, upravljanja I korištenja kulturne baštine, a temeljen na krajoliku. Uzor za razvijanje modela je upravo Engleski model valorizacije baštine kroz platformu Povijesne Karakterizacije Krajolika (Historic Landscape Characterisation - HLC). Metodologija za provođenje projekta je metodologija arheologija krajolika. Studija slučaja koja je izabrana za izradu modela je područje današnje Općine Jasenice i Grada Obrovca. Područje studije slučaja predstavlja dovoljno velik prostorni uzorak za primjenu temeljnih principa Povijesne Karakterizacije Krajolika. Ova platforma, jednako kao i procedure će biti dodatno razrađene uzevši u obzir specifičnosti baštine u kršu. Modeli koji će nastati kroz ovaj projekt će biti primjenjivi za ostale krške dijelove Hrvatske, a na metodološkoj razini i na cijelu zemlju. Osim valorizacije i zaštite baštine projekt za cilj ima i razvijanje primijenjene arheologije kao svojevrsne ekstenzije primarne struke, a kroz sinergiju sa društvenim znanostima. Interdisciplinarnost je sadržana u radu na području razvoja kulturnog i baštinskog turizma. Koraci u tom smjeru su izrada zajedničkog kategorijskog aparata, jedinstvene terminologije, akcijskih planova i strategija s ciljem uspostave procedura za upravljanje i korištenje baštine po principu održivosti, a ujedno usmjerene na očuvanje prostora, krajolika i baštine.]]></summary_hr><summary_en><![CDATA[Archaeology has experienced several transformations in the last 20 years. Apart from epistemological and theoretical turns, archaeology was shaped by new technologies and new media enabling new perspectives and areas of practice. One of the greatest transformations which happened in archaeology was the development of landscape archaeology. This turn was followed by various legislation, the most significant being European Landscape Convention (Florence 2000). Accordingly, new methods and procedures were developed including valorisation, protection and heritage management based on landscape.The aim of this project is to developed Croatian model of valorisation, protection, management and use of cultural heritage, based on the landscape. The role model is precisely the English model of heritage valorisation through Historic Landscape Characterisation (HLC) platform. Project methodology is in fact a methodology developed within landscape archaeology. The case study selected to develop the model is an area of Jasenice Municipality and Town of Obrovac. It presents a large enough spatial sample to apply basic HLC principles. This platform as well as the procedures will be additionally developed considering specificities of heritage in karst. Models that will be created through this project will be applicable on other karst areas in Croatia and at the methodological level on the whole country. Apart from valorisation and protection of heritage, the aim of the project is to develop applied archaeology as an extension of the primary discipline, through synergy with social sciences. Interdisciplinarity of the project is reflected in areas such as the development of cultural and heritage tourism. Steps in that direction include conceptualisation of joint categorical apparatus and terminology, action plans and strategies in order to establish procedures for management and use of heritage based on sustainability principles and preservation of space, landscape and heritage.]]></summary_en></project><project>
<id>9456</id><title_hr><![CDATA[REWAISE – Resilient Water Innovation for Smart Economy]]></title_hr><title_en><![CDATA[]]></title_en><user_id>7612</user_id><user_firstLast_name>Mario Vašak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-4118</code><acronim><![CDATA[]]></acronim><duration>01.10.2020 - 30.09.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>856184</team_members_id><team_members_names><![CDATA[ Doktorand: Blaž Korotaj Korotaj ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>9457</id><title_hr><![CDATA[Zbrinjavanje mulja kroz proizvodnju energetskih kultura]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5606</user_id><user_firstLast_name>Neven Voća</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-9784</code><acronim><![CDATA[Mud4BioEnergy]]></acronim><duration>19.10.2020 - 18.10.2024</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Agronomski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Agriculture]]></institution_en><team_members_id>858338</team_members_id><team_members_names><![CDATA[ Doktorand: Jona Šurić ]]></team_members_names><keywords_hr><![CDATA[Primjena mulja, energetske kulture, prinos, žetva, biogoriva]]></keywords_hr><keywords_en><![CDATA[Sludge application, energy crops,  yield,  harvest, biofuels]]></keywords_en><summary_hr><![CDATA[Prioritetna politika Europske unije jest da se mulj dobiven nakon pročistača otpadnih voda koristi na ekonomski optimalan način u poljoprivrednom sektoru te da se ukoliko je to moguće izbjegne njegovo spaljivanje. Zbrinjavanje mulja u poljoprivredi je definirano strogim propisima i direktivama koje nisu razdvojile njegovo korištenje u prehrambenoj ili neprehrambenoj proizvodnji. Postoje velike mogućnosti za napredak u isplativosti efikasne primjene mulja na tlo i to u količinama koje su veće od definiranih, bez ikakve opasnosti i mogućeg prodora štetnih tvari u okoliš. Naime, Pravilnikom o primjeni mulja u poljoprivrednoj proizvodnji u RH propisana je količina od najviše 1,66 tona suhe tvari mulja godišnje po hektaru poljoprivrednog zemljišta, bez obzira na vrstu poljoprivredne proizvodnje. Međutim, unatoč tim ograničenjima, kroz korištenje energetskih kultura postoji mogućnost obilnijeg korištenja mulja kao gnojiva. Procjene govore da bi se na taj način poljoprivredne površine višestruko reducirale u smislu intenzivnijeg zbrinjavanja mulja u poljoprivredi. Isto tako, idealno bi se korištenje mulja uklopilo upravo u proizvodnju energetskih kultura, koje bi bile oslobođene problema sa zdravstvenom reputacijom proizvoda. Ovom metodom mogla bi se iskoristiti tla lošije kvalitete i nepovoljnih agroklimatskih uvjeta koja ne mogu konkurirati u konvencionalnoj proizvodnji hrane. Zbog svega navedenog, kao idealne energetske kulture se nameću sterilna rizomatska trava Miscanthus x giganteus i biljka iz porodice sljezova Sida hermaphrodita. Cilj ovoga istraživanja analiza je biomase navedenih energetskih kultura, gnojenih različitim količinama mulja iz pročistača otpadnih voda, jednako u energetskom i ekološkom smislu. Isto tako, veliki izazov u uzgoju energetskih kultura leži u pravilnom odabiru datuma žetve, a samim time i smjeru korištenja biomase za potrebe proizvodnje različitih biogoriva.]]></summary_hr><summary_en><![CDATA[EU priority policy is a feasible utilization of sludge from wastewater treatment plant in the agricultural sector while avoiding its incineration. Sludge disposal in the agricultural sector is defined by strict regulations and directives which do not distinguish its utilization in food or non-food production. There is a great potential for improvement in terms of efficient sludge application to the soil, in larger quantities, without any danger or possible breaking of harmful substances into the environment. Regulations on the sludge application in agricultural production in Croatia is regulated by the amount of up to 1.66 t of sludge DM/year per ha of arable land, regardless of the type of agricultural production. However, despite these limitations, through the use of energy crops, there is a possibility of plentiful sludge use as a fertilizer. According to estimations, arable land will be greatly reduced in terms of intensive sludge management in agriculture in this way. Ideally, the use of sludge would fit right in the production of energy crops, which would be exempt from the problems with the healthy reputation of the product. Furthermore, this method could be used in lower quality soils and unfavorable climatic conditions that cannot compete with conventional food production. Consequently, sterile grass Miscanthus x giganteus and Mallow family plant Sida hermaphrodita are imposed as deal energy crops. The aim of this research is the analysis of those energy crops, fertilized with various quantities of sludge from the wastewater treatment plant. Also, a major challenge in energy crops growing lies in the proper selection of the harvesting date, as well as in choosing the optimal biofuel production pathway. ]]></summary_en></project><project>
<id>9458</id><title_hr><![CDATA[Transport, sudbina i toksičnost metal(oid)a otpuštenih iz ležišta industrijskog otpada]]></title_hr><title_en><![CDATA[]]></title_en><user_id>2726</user_id><user_firstLast_name>Željka Fiket</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-9093</code><acronim><![CDATA[FORtIS / FORtIS]]></acronim><duration>01.10.2020 - 30.09.2025</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Interdisciplinarne prirodne znanosti, </scie_field_hr><scie_field_en>Interdisciplinary natural sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>858378</team_members_id><team_members_names><![CDATA[ Doktorand: Marija Petrović ]]></team_members_names><keywords_hr><![CDATA[odlagališta otpada, geokemija okoliša, biogeokemija, toksičnost, ranjivost podzemnih voda, procjedne vode]]></keywords_hr><keywords_en><![CDATA[waste deposits, environmental geochemistry, biogeochemistry, toxicity, groundwater vulnerability, waste leachates]]></keywords_en><summary_hr><![CDATA[Depoziti nastali odlaganjem industrijskog otpada predstavljaju dugotrajnu opasnost od onečišćenja kao potencijalna mjesta otpuštanja raznih onečišćujućih tvari, uključujući i metal(loid)e, s mogućnošću ozbiljnog zagađenja tla, površinskih i podzemnih voda u regiji, čak i desetljećima nakon njihovog odlaganja. Projekt FORtIS ima za cilj istražiti svojstva i utjecaj na okoliš četiri različita odlagališta industrijskog otpada obogaćenog metal(oid)ima koristeći, između ostalog, i svojstva procjednih voda. Područja istraživanja uključit će odlagalište ugljenog pepela i odlagalište pepela bivše tvornice sulfatne celuloze kao otpadni materijal visoke opasnosti, deponij tvornice čelika kao otpadni materijal srednjeg stupnja opasnosti, te bivšu tvornicu glinice kao otpad materijal umjerene opasnosti.Specifični ciljevi projekta uključuju: 1) ispitivanje osnovnih značajki otpada I okolnih tala, 2) istraživanje geokemijskih i mineralnih svojstava otpada i okolnih tla, 3) ispitivanje svojstava eluata otpada i okolnih tla, 4) istraživanje ekotoksikoloških značajki procjednih voda; 5) procjena mogućeg utjecaja na okoliš.Transport, sudbina i toksičnost metal(oid)a koji se otpuštaju iz spomenutih depozita industrijskog otpada istražit će se kroz skup fizikalno-kemijskih, morfoloških, mineraloških, geokemijskih i bioloških parametara kao i primjenom geokemijskog modeliranja i procjene rizika.Rezultati istraživanja pridonijet će razumijevanju načina pojavljivanja metal(oid)a koji se otpuštaju iz istraženih i sličnih vrsta otpada, procesa i mehanizama koji utječu na njihov ciklus u okolišu kao i detaljniji uvid u njihove bioreaktivne oblike. Rezultati projekta FORtIS predstavljat će važan doprinos znanju potrebnom za određivanje i provedbu strategija čiji je cilj minimiziranje negativnih utjecaja na okoliš vezanih uz odlaganje industrijskih otpada obogaćenih metal(oid)ima.]]></summary_hr><summary_en><![CDATA[Deposits arising from industrial waste disposal operations represent a long-term pollution risk as potential release points of various pollutants, including metal(loid)s, with the ability to severely contaminate soils, surface and groundwater in the region, even decades after their disposal. Project FORtIS aims to address the environmental impact of four different industrial waste deposits enriched in metal(loid)s using, inter alia, their leachates features. The location of interest will include the coal ash deposit and the ash deposit of the former sulphate cellulose factory as waste materials of high hazard score, the scrapyard of the steel factory as waste materials of medium hazard score, the ex-alumina factory deposit as waste materials of moderate hazard score.Specific objectives of the project will include the investigation of 1) the basic characteristics of the waste and surrounding soils, 2) the geochemical and mineral characteristics of waste and surrounding soils, 3) the chemistry of waste and soil leachates, 4) the ecotoxicological features of waste and soil leachates, and the assessment of 5) the potential environmental impact. Transport, fate and toxicity of metal(loid)s released from mentioned industrial waste deposits will be investigated through a set of physico-chemical, morphological, mineralogical, geochemical and biological parameters as well as the geochemical modeling and risk assessment. Results of the research will contribute to the understanding of the modes of occurrences of metal(loid)s released from investigated and similar waste deposits, processes and mechanisms that influence their environmental cycling, as well as more detailed insight into their bioreactive forms. The results of the FORtIS project will present an important contribution to the knowledge necessary to determine and implement strategies aimed at minimizing the negative environmental impacts related to deposition of industrial wastes enriched in metal(loid)s.]]></summary_en></project><project>
<id>9459</id><title_hr><![CDATA[Istraživanje efikasnijeg i ekološki prihvatljivijeg izgaranja u Ottovim motorima s pretkomorom]]></title_hr><title_en><![CDATA[]]></title_en><user_id>11160</user_id><user_firstLast_name>Darko Kozarac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-5726</code><acronim><![CDATA[EF-PRECOM]]></acronim><duration>01.06.2021 - 31.05.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, </scie_field_hr><scie_field_en>Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>864976</team_members_id><team_members_names><![CDATA[ Doktorand: Viktor Dilber ]]></team_members_names><keywords_hr><![CDATA[pretkomora, izgaranje, učinkovitost, emisije, motor s unutarnjim izgaranjem]]></keywords_hr><keywords_en><![CDATA[pre-chamber, combustion, efficiency, emissions, internal combustion engine]]></keywords_en><summary_hr><![CDATA[Porast ekološke svijesti posljednjih godina doveo je do značajnog povećanja aktivnosti usmjerenih k smanjenju štetnog utjecaja sektora transporta, kao jednog od najvećih zagađivača, na okoliš. Električna vozila se zbog izazova s kojima se trenutno suočavaju mogu smatrati tek dugoročnim rješenjem dok, s obzirom na sve izraženije posljedice globalnog onečišćenja, postoji potreba za rješenjima koja će barem djelomično ublažiti štetne učinke, a mogu se primijeniti u mnogo kraćem vremenskom okviru. Posljednja istraživanja ukazuju kako Ottovi motori s pretkomorom predstavljaju jednu od ključnih tehnologija u ostvarivanju tih ciljeva. Ipak, dosadašnja istraživanja još uvijek nisu u potpunosti odgovorila na sve izazove za masovnu primjenu ove tehnologije u cestovnim vozilima. Iz pregleda literature identificirana su glavna područja od interesa, u skladu s čime su formirani ciljevi istraživanja. Za pogon benzinom ispitat će se utjecaj volumena i geometrije pretkomore uz zadržavanje konstantne energije goriva u pretkomori te istražiti mogućnost primjene naprednog načina izgaranja (PCHCCI) za poboljšanje rada motora. Za pogon prirodnim plinom ispitat će se primjena i utjecaj povrata ispušnih plinova te različite strategije ispiranja pretkomore što se pokazalo kao jedna od značajnijih problematika u Ottovim motorima s pretkomorom. Prije navedenih ispitivanja modificirati će se i unaprijediti trenutni eksperimentalni postav kako bi se omogućio rad motora s pretkomorom te sva potrebna mjerenja. Glavna svrha ovog istraživanja je temeljitim eksperimentalnim ispitivanjima potpomognutim naprednim numeričkim simulacijama i proračunima, a usmjerenim na dosad neodgovorena pitanja i izazove, dati znanstveni doprinos u istraživanju efikasnijeg i ekološki prihvatljivijeg načina izgaranja u Ottovim motorima te postići dodatni iskorak u pronalasku rješenja za smanjenje globalnog onečišćenja na dobrobit okoliša i cjelokupnog čovječanstva.]]></summary_hr><summary_en><![CDATA[Increased environmental awareness in recent years has led to a significant increase in the activities aimed at reducing the negative impact of the transport sector, as one of the largest polluters, on the environment. Electric vehicles, because of the challenges they currently face, can be considered only as a long-term solution while, given the pronounced effects of global pollution, there is a need for solutions that will at least partially mitigate harmful effects in a much shorter time frame. Recent research indicates that pre-chamber (PC) SI engines represent one of the key technologies in achieving those goals. However, investigations have not yet fully responded to all the challenges for mass application of this technology in road vehicles. From the literature review the main areas of interest are identified, in accordance with which the research objectives were formed. For operation with gasoline the influence of volume and geometry of the PC with constant energy of the fuel in the PC will be examined and the possibility of applying advanced combustion mode (PCHCCI) to improve the operation of the engine will be explored. For operation with natural gas the application and impact of EGR will be examined, as well as different strategies for PC scavenging, which proved to be one of the most important topics in such engines. Prior to the above tests it is necessary to modify and improve the current experimental set-up in order to enable the operation of the engine with PC, as well as all the necessary measurements. The main purpose of this research is to give a scientific contribution in the research of more efficient and environment-friendly combustion by thorough experimental studies, assisted by advanced numerical simulations and calculations directed to unanswered questions and challenges, thus achieving an additional step forward in finding solutions to reduce global pollution for the environment and to improve human life.]]></summary_en></project><project>
<id>9461</id><title_hr><![CDATA[Ličnost, emocije i radna uspješnost nastavnika: dinamička perspektiva]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6118</user_id><user_firstLast_name>Irena Burić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-1052</code><acronim><![CDATA[TEPEPDYN]]></acronim><duration>01.02.2021 - 31.01.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Psihologija, </scie_field_hr><scie_field_en>Psychology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zadru]]></institution_hr><institution_en><![CDATA[University of Zadar]]></institution_en><team_members_id>865284</team_members_id><team_members_names><![CDATA[ Doktorand: Krešimir Jakšić ]]></team_members_names><keywords_hr><![CDATA[nastavnici, ličnost, emocije, regulacija emocija, radna uspješnost, dinamička perspektiva]]></keywords_hr><keywords_en><![CDATA[teachers, personality, emotions, emotion regulation, performance, dynamic perspective]]></keywords_en><summary_hr><![CDATA[Posljednjih godina istraživanja emocija i emocionalne regulacije nastavnika su u stalnom porastu. Prepoznato je kako su različite diskretne emocije nastavnika i strategije emocionalne regulacije povezane s dobrobiti nastavnika, njihovom radnom uspješnošću i učeničkim ishodima. Unatoč ovim značajnim spoznajama, još je uvijek potrebno odgovoriti na velik broj važnih pitanja. Primjerice, istraživanja o ulozi emocija nastavnika i emocionalne regulacije u predviđanju njihove kvalitete poučavanja i učeničkih kognitivnih, afektivnih i motivacijskih ishoda su i dalje rijetka i gotovo isključivo temeljena na transverzalnim nacrtima pomoću kojih se ne mogu utvrditi uzročni mehanizmi u podlozi. Uz to, uzimajući u obzir činjenicu da osobine ličnosti utječu na emocije i emocionalnu regulaciju te radnu uspješnost nastavnika, istraživanja uloge stabilnijih karakteristika ličnosti nastavnika u predviđanju njihovih emocionalnih procesa i radne uspješnosti od velike je važnosti. Na kraju, unatoč tome što suvremene teorije emocija jasno naglašavaju njihovu dinamičku i prilagodljivu prirodu i da noviji teorijski okviri ličnosti naglašavaju dinamičku integraciju crta, konteksta i trenutnih psiholoških stanja, emocije nastavnika i emocionalna regulacija do sada su uglavnom bile definirane kao stabilne crte ili kao kratkotrajna stanja statična u vremenu. Stoga je cilj ovog projekta istražiti ulogu emocija nastavnika i emocionalne regulacije u objašnjenju njihove radne uspješnosti vodeći pritom računa o učincima stabilnih osobina ličnosti i promjenjivih situacijskih karakteristika te uzimajući u obzir dinamičnu prirodu emocionalnih iskustava nastavnika. Kako bi se postigao ovaj cilj, prikupit će se podaci od nastavnika i njihovih učenika te će se implementirati sofisticirane longitudinalne metode kako bi se utvrdili uzročni mehanizmi u podlozi koji bi mogli objasniti povezanosti između konstrukata koji se istražuju.]]></summary_hr><summary_en><![CDATA[In recent years, research on teacher emotion and emotion regulation has been steadily progressing. Varieties of discrete teacher emotions and emotion regulation strategies have been recognized to relate to teacher well-being, their performance, and student outcomes. In spite of these important insights, many questions are yet to be addressed. For example, the empirical evidence regarding the role of teachers’ emotions and emotion regulation in predicting their instructional quality and students’ cognitive, affective, and motivational outcomes are still rather scarce and almost exclusively based on cross-sectional designs that cannot reveal underlying causal mechanisms. In addition, considering the fact that personality traits are recognized to affect emotions and emotion regulation, as well as teacher performance, investigation the role of teacher more stable personality characteristics in predicting their emotional processes and performance is of great importance. Lastly, even though contemporary theories on emotions readily acknowledge their dynamic and malleable nature and that emerging personality frameworks emphasize the dynamic integration of traits, contexts, and momentary psychological states, teachers’ emotions and emotion regulation have been mostly conceptualized as stable traits or as brief states static in time. Therefore, the current project proposal aims to explore the role of teachers’ emotions and emotion regulation in explaining their performance while acknowledging the effects of stable personality dispositions and malleable situational characteristics and considering the dynamic nature of teachers’ emotional lives. In order to achieve this aim, data from teachers and their students will be collected and sophisticated longitudinal methods will be implemented to reveal the underlying causal mechanisms that can explain the associations between the constructs under study. ]]></summary_en></project><project>
<id>9462</id><title_hr><![CDATA[Tehnologija preprekama i 3D printanje za okolišno prihvatljivu proizvodnju funkcionalnih voćnih sokova]]></title_hr><title_en><![CDATA[]]></title_en><user_id>2615</user_id><user_firstLast_name>Danijela Bursać Kovačević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-9050</code><acronim><![CDATA[3D-SustJuice]]></acronim><duration>20.10.2020 - 19.01.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Prehrambena tehnologija, </scie_field_hr><scie_field_en>Food technology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Food Technology and Biotechnology]]></institution_en><team_members_id>858394</team_members_id><team_members_names><![CDATA[ Doktorand: Anica Bebek Markovinović ]]></team_members_names><keywords_hr><![CDATA[Tehnologija preprekama, 3D printanje, funkcionalni voćni sok, autohtone voćne vrste, održivost]]></keywords_hr><keywords_en><![CDATA[Hurdle technology, 3D print, functional fruit juice, autochthonous fruit, sustainability ]]></keywords_en><summary_hr><![CDATA[Republika Hrvatska (RH) ima dugu tradiciju uzgoja voća zbog posebnog zemljopisnog položaja, klimatskih prilika te kvalitetne sirovine. Unatoč dobrim morfološko–pomološkim karakteristikama starih autohtonih voćnih vrsta, njihov nutritivni sastav te biološki potencijal nedovoljno je istražen, kao i mogućnost prerade u funkcionalne voćne sokove, koji su u velikoj potražnji na tržištu. Sve veća intolerancija na laktozu i nemogućnost konzumacije funkcionalnih mliječnih proizvoda otvara mogućnost prerade ovih voćnih vrsta u funkcionalne voćne sokove. Preradom u sok, generira se značajan udio nusproizvoda koji predstavlja odličan izvor biološki aktivnih spojeva (BAS). Stoga će se ovim projektom ispitati uporaba selektiranih autohtonih voćnih vrsta u održivoj proizvodnji funkcionalnih voćnih sokova uz dodatak odabranih probiotičkih kultura i BAS-a izoliranih iz nusproizvoda. Klasična toplinska obrada (pasterizacija) narušava stabilnost termolabilnih molekula BAS-a, stoga će se istražiti primjena „tehnologije preprekama“ („hurdle“) tj. kombinacija netoplinskih tehnologija ultrazvuka visokog intenziteta (HPU) i pulsirajućeg električnog polja (PEF). S ciljem spajanja tradicije i inovacije primijeniti će se aditivna tehnologija 3D-printanja (3DP) za dizajn proizvoda jedinstvenog sastava i geometrije te produženog roka trajanja. 3DP funkcionalni voćni sokovi proizvedeni od autohtonih voćnih vrsta predstavljat će jedinstvene hrvatske voćne suvenire, a u skladu  s temeljnim smjernicama kružnog gospodarstva i turizma RH. Tako se cilja razviti održive načine prerade koji će potrošaču osigurati unikatan, nutritivno vrijedan, zdravstveno ispravan, atraktivan i kvalitetan prehrambeni proizvod na ekonomski prihvatljiv način.]]></summary_hr><summary_en><![CDATA[Republic of Croatia has a long tradition of fruit cultivation due to its geographic position, climatic conditions and high quality of fruit crops. Autochthonous fruit varieties are characterized by good morphological/pomological characteristics, but their nutritional and biological potential have been underestimated, as well as their ability to be processed into juices that are in high demand on the market. Increased lactose intolerance in population that is complemented with inability to consume functional dairy products led to the opportunity for processing of autochthonous fruit varieties into functional fruit juices. During the processing into juice, a significant amount of by-products is produced. This represents a high-value raw material for the isolation of biologically active compounds (BACs). Therefore, this project will examine the use of selected autochthonous fruit species in sustainable production of functional juices with addition of selected probiotic cultures and/or BACs isolated from the by-products. Classical heat treatment (pasteurization) disrupts the stability of the thermoluble BAS molecules, so the application of nonthermal &#39;&#39;hurdle technology&#39;&#39;, i.e. the combination of high intensity ultrasound (HPU) and pulse electric field (PEF) technology will be investigated.In order to combine tradition and innovation, additive technology e.g. 3D-printing (3DP) will be applied to design products of unique composition, geometry and extended shelf-life. 3DP functional fruit juices produced from autochthonous fruit varieties will represent unique Croatian fruit souvenirs, in line with the core principles of the Croatian circular economy and tourism. That way the aim is to develop sustainable ways of processing that will provide the consumers with a unique, healthy, attractive, and high quality food product in an economically acceptable way.]]></summary_en></project><project>
<id>9463</id><title_hr><![CDATA[Fenomeni na površini tijekom priprave naprednih nanokompozita infiltracijom i funkcionalizacijom poroznih materijala]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1338</user_id><user_firstLast_name>Vilko Mandić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-2359</code><acronim><![CDATA[SLIPPERYSLOPE]]></acronim><duration>10.09.2020 - 27.10.2026</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Kemijsko inženjerstvo, </scie_field_hr><scie_field_en>Chemical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet kemijskog inženjerstva i tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Chemical Engineering and Technology]]></institution_en><team_members_id>861734</team_members_id><team_members_names><![CDATA[ Doktorand: Arijeta Bafti ]]></team_members_names><keywords_hr><![CDATA[Površine, Poroznost, Infiltracija, Nanomaterijali, Grazing, Skliski kompoziti, Postupno otpuštanje]]></keywords_hr><keywords_en><![CDATA[Surface, Porous, Infiltration, Nanomaterials, Grazing, Slippery composites, Sustained release]]></keywords_en><summary_hr><![CDATA[Neophodno je unaprijediti pokazatelje učinkovitosti funkcionalnih materijala. U zadnje vrijeme, ova nejasna izjava prati istraživanje i razvoj naprednih materijala, kompozita i strukturiranih materijala koji teže uređenosti i funkcionalnosti na nano razini. Kao praktični ishod tijeka istraživanja česte su izjave poput: mehanizmi i razmjer kontakta faza nisu jasni na temelju čega je utvrđena potreba za daljnjim istraživanjem…Suprotno tome, ovaj projekt jasno utvrđuje da su procesi na i oko površine ključne za postizanje unaprjeđenja u širokom području naprednih materijala. Naime, istraživači koji se bave površinama još u potpunosti ne kontroliraju procese u planarnim uzorcima među sastavno jednostavnim fazama pri atmosferskim uvjetima. U tum duhu, ovaj projekt želi posvetiti pažnju razjašnjavanju složenijih aspekata istraživanja površina materijala.Posebno atraktivno i kompleksno, a nedovoljno istraženo je područje kontakta poroznih ili nanostrukturiranih materijala sa drugim materijalima korištenjem metoda mokre kemije. Problemi razumijevanja mehanizama unaprjeđenja svojstava materijala prilikom kontakta poroznih čvrstih i kapljevitih materijala su još izraženiji. Praćenje takvih konfiguracija praćeno je ključnim pitanjima:1) Kako kontrolirati procese potrebne za pripravu takvih materijala i svojstva?2) Kako uočiti, potvrditi i procijeniti pripravljene materijale i svojstva?3) Kako razumjeti i predvidjeti ponašanje materijale i svojstva?Cilj projekta je uspostaviti efikasnu ustraživačku grupu sa nezavisnim smjerom istraživanja u znanosti materijala. Grupa će na temelju dosadašnjih pokazatelja izvrsnosti i uspostavljenih domaćih i međunarodnih kanala suradnje biti u stanju interdisciplinarno primijeniti rezultate ovog istraživanja.]]></summary_hr><summary_en><![CDATA[The increase of performance parameters of functional materials is recently becoming increasingly important. In recent times, this relatively ambiguous expression accompanies the course of development of various composites, materials reaching to nano-seizes, materials implementing ordered structuration, etc. In reality, it seems that the outcome of this course of development is commonly the need to conduct further investigation since, for example, it was found that the mechanisms of the extent of the interfacing of the phases are not clear…Opposite of that, this project identifies the reactions at broader surface region as a bottleneck for upgrading performance of broad range of functional materials. Namely, the surface researchers still struggle to fully understand reactions even at planar samples between phases having simple composition that are stable at atmospheric conditions. Therefore, this project aim to devote more attention in more complex aspects of the surface science. The especially ambiguous area are porous or nanostructured oxide materials interfaced with other oxide materials using soft chemistry techniques to form heterostructures. Even more difficult is understanding of the systems where the properties of hard materials should be improved upon infiltration with special soft matter or liquids. Mentioning of such configurations immediately raise question such as: 1) How to control processes behind achieving the feature? 2) How to observe, confirm and evaluate the achieved feature? 3) How to understand and predict the performance of feature? The aim is to establish effective research group with independent course of research in material science. The group would benefit on excellent recent track-record and established national and international collaboration pathways to allow interdisciplinary applicability of the project results. ]]></summary_en></project><project>
<id>9465</id><title_hr><![CDATA[Proširenje osjetilnosti senzora u laboratoriju za obradbu i analizu podataka iz okoline]]></title_hr><title_en><![CDATA[]]></title_en><user_id>22609</user_id><user_firstLast_name>Hrvoje Kalinić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-2008</code><acronim><![CDATA[SSA@EDAL]]></acronim><duration>01.02.2021 - 31.01.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Temeljne tehničke znanosti, </scie_field_hr><scie_field_en>Basic engineering sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Science]]></institution_en><team_members_id>862804</team_members_id><team_members_names><![CDATA[ Doktorand: Leon Ćatipović ]]></team_members_names><keywords_hr><![CDATA[software sensor augmentation, artificial intelligence, neural networks, data reconstruction, meteorology, traffic analysis, transfer learning]]></keywords_hr><keywords_en><![CDATA[software sensor augmentation, artificial intelligence, neural networks, data reconstruction, meteorology, traffic analysis, transfer learning]]></keywords_en><summary_hr><![CDATA[U sklopu projekt bit će uspostavljen laboratorij za obradbu i analizu podataka iz okoline (EDAL). Jezgra grupe i fizički prostor će biti na Prirodoslovno-matematičkom fakultetu, a da bi se olakšala suradnja između članova tima i suradnika koji dolaze sa Sveučilišta u Zagrebu, Sveučilišta u Skopju, Instituta Ericsson Nikola Tesla i Instituta za ocenaografiju i ribarstvo, predviđen je i virtualni dio laboratorija za pohranu i razmjenu podataka. Istraživački ciljevi projekta je proučavanje modela strojnog učenja u svrhu proširenja osjetilnosti senzora. Proširenje osjetilnost senzora podrazumijeva procjenu podataka u točkama gdje (ili kada) podatci nisu mjereni, a temelji se na pretpostavci da je moguće pronaći reprezentaciju znanja koja dobro opisuje promatrani fenomen. Naučivši reprezentaciju znanja pohranjenog u podatcima to znanje možemo pohraniti ili prebaciti na drugi sustav. Na taj način drugi sustavi mogu profitirati od bolje incijalizacije i brže konvergencije ka rješenju problema. Naučena reprezentacija predstavlja komprimiranu informaciju, odnosno omogućava da se prati manja količina podataka koja nosi istu količinu informacije. Naučene reprezentacije se mogu primijeniti za rekonstrukciju podataka i tako proširiti osjetilnost senzora, što može rezultirati efikasnijim korištenjem resursa, s pozitivnim utjecajem na gospodarstvo i okoliš. Potencijalne primjene takvog osjetila mogu se predvidjeti u klasičnim sustavima za monitoring kao što je meteorologija, promet ili EU monitoring u ribarstvu. U IoT svijetu, razmjena informacija između senzora i zaključivanje na temelju podataka dobivenih iz različitih domena će prije biti pravilo, no iznimka - za što ovakvo istraživanje daje dobru podlogu.]]></summary_hr><summary_en><![CDATA[One of the project goals is to establish Environmental Data Analysis Laboratory (EDAL). EDAL core and physical space is to be located at University of Split, Faculty of Science. In order to ease cooperation with partners which come from University of Zagreb, University of Skopje, Institute Ericsson Nikola Tesla and Institute of Oceanography and Fisheries, a virtual laboratory for data storage and exchange will be organized. Scientific goals of the project assume machine learning models investigation for the purpose of software sensor augmentation (SSA). SSA denotes estimation of measurements in points where (or when) data has not been acquired, and assumes that it is possible to find knowledge representation which describes the problem well. By learning representation from the data the knowledge can be stored or transferred to another system (or problem domain). This can result in better initialization and faster convergence rate of such systems. Learned representation compresses the information and can be utilized in problems where lesser amount of data is necessary to transfer the same amount of information. Learned representation can be applied for data reconstruction and thus augment the sensor capabilities, which can result in more efficient  resource utilization with positive effects on industry and environment. Potential applications are in classical monitoring systems such as meteorology, transport or EU monitoring (e.g. of a fish stock). In IoT world, the exchange of information between sensors and inferring from data based on data from different domains is becoming a rule, rather than exception - and this research follows this direction.]]></summary_en></project><project>
<id>9466</id><title_hr><![CDATA[CNS-active, Orally Bioavailable, Zwitterionic Oxime Antidote to Organophosphates]]></title_hr><title_en><![CDATA[]]></title_en><user_id>411</user_id><user_firstLast_name>Nikolina Maček Hrvat</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-9895</code><acronim><![CDATA[]]></acronim><duration>01.10.2020 - 30.09.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut za medicinska istraživanja i medicinu rada]]></institution_hr><institution_en><![CDATA[Institute for Medical Research and Occupational Health]]></institution_en><team_members_id>861724</team_members_id><team_members_names><![CDATA[ Doktorand: Dora Kolić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>9467</id><title_hr><![CDATA[Utjecaj klimatskih promjena na bioraznolikost koralja - istraživanje slučaja masovnih ugibanja u Jadranskom moru]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4351</user_id><user_firstLast_name>Petar Kružić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-1532</code><acronim><![CDATA[ADRICOR]]></acronim><duration>01.12.2020 - 30.05.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>858428</team_members_id><team_members_names><![CDATA[ Doktorand: Pavel Ankon Ankon ]]></team_members_names><keywords_hr><![CDATA[Klimatske promjene, koralji, bioraznolikost, ugroženost, Jadransko more]]></keywords_hr><keywords_en><![CDATA[Climate change, corals, biodiversity, endanger, Adriatic Sea]]></keywords_en><summary_hr><![CDATA[Znanstvenici i upravitelji zaštićenih područja prepoznali su hitnu potrebu za poboljšanim metodama i alatima koji će omogućiti učinkovitu prilagodbu mjera upravljanja u uvjetima klimatskih promjena. Predloženi projekt se polazi iz znanstvenog i terenskog iskustva prikupljenog tijekom procjene utjecaja masovnih ugibanja koralja u različitim područjima Jadranskog mora. Projekt je razvijen usredotočujući se na glavne vrste koralja koje žive u plitkim vodama (0-50 m) u istočnom dijelu Jadranskog mora. Međutim, dobiveni rezultati projekta se također mogu prilagoditi kako bi se procijenio utjecaj na druge vrste sesilnih vrsta podmorja. Glavni cilj projekta je postaviti očuvanje ispitanih populacija ugroženih koralja uz prikupljanje osnovnih informacija kako bi se procijenili učinci događaja masovnih ugibanja kada do njih dođe. Godišnja istraživanja na odabranim mjestima pružit će polazne vrijednosti za procjenu mogućeg negativnog učinaka. Cilj projekta nije zaustaviti utjecaj klimatskih promjena, već pomoći u razumijevanju kako dodatno smanjiti negativan antropogeni utjecaj na podmorja Jadrana. Cilj projekta je steći nove informacije o posljedicama globalnih klimatskih promjena na ekosustav mora, posebno u obalnom području. Projekt identificira i karakterizira negativne utjecaje na biološku raznolikost mora i razvija sposobnost predviđanja budućih promjena. Kako bi ostvarili zadane ciljeve, projekt predlaže multidisciplinarni pristup koji integrira različite razine biološke organizacije, od jedinki do populacija i zajednica, u određenom prostoru i vremenu. ]]></summary_hr><summary_en><![CDATA[Scientists and managers of natural resources have recognized an urgent need for improved methods and tools to enable effective adaptation of management measures in the face of climate change. The proposed protocol is based on scientific and field experience gathered during the assessment of mass mortality impact in different areas of the Adriatic Sea. The project has been developed focusing in main coral species dwelling in shallow waters (0-50 m) in the Eastern part of the Adriatic Sea. However, the project can be adapted to assess the impact on other macrobenthic species. The main goal of the project is to preserve the populations surveyed by collecting basic information to assess the effects of mass mortalities. Annual research at selected sites will provide initial values for assessing possible negative effects. The project&#39;s goal is not to stop the negative impact of climate change, but to help understand how to further reduce the negative anthropogenic impact on the Adriatic Sea. The objective of the project is to gain new information regarding the consequences of global climate change on marine ecosystems, particularly in coastal regions. The project identifies and characterizes negative impacts on marine biodiversity and develops methods and models for predicting future changes. To achieve these goals, the project proposes a multidisciplinary approach that integrates different levels of biological organization, from individuals to populations.]]></summary_en></project><project>
<id>9468</id><title_hr><![CDATA[Nano-katalizatori aktivirani Sunčevim zračenjem u tehnologijama zaštite okoliša]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3651</user_id><user_firstLast_name>Marijana Kraljić Roković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-6215</code><acronim><![CDATA[NaSCEnT]]></acronim><duration>10.09.2020 - 10.11.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Kemijsko inženjerstvo, </scie_field_hr><scie_field_en>Chemical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet kemijskog inženjerstva i tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Chemical Engineering and Technology]]></institution_en><team_members_id>856133</team_members_id><team_members_names><![CDATA[ Doktorand: Gabrijela Radić ]]></team_members_names><keywords_hr><![CDATA[solarna fotokataliza, nanokompozitni katalizatori, prioritetna onečišćivala, pročišćavanje vode, proizvodnja vodika]]></keywords_hr><keywords_en><![CDATA[solar photocatalysis, nanocomposite catalysts, priority substances, water purification, hydrogen production]]></keywords_en><summary_hr><![CDATA[Pristup pitkoj vodi i izvorima čiste energije neophodni su za ekonomski razvitak i napredak društva. Međuzavisnost proizvodnje energije i čiste vode dobro je poznata, međutim tehnologije trenutno nisu adekvatno integrirane. Inovativna ideja na kojoj počiva NaSCEnT projekt je dobivanje energije tijekom pročišćavanja vode. Takva hipoteza je utemeljena na istovjetnosti mehanizama koji se odvijaju tijekom fotokatalitičkog pročišćavanja vode te fotoelektrokemijskog cijepanja vode u svrhu dobivanja energije, to jest proizvodnju vodika (H2). Naime, oba procesa se temelje na istom osnovnom mehanizmu koji uključuje generiranje parova elektron/šupljina (e-/h+) na površini poluvodiča uslijed ekscitacije svjetlom, odnosno fotonima odgovarajuće energije. Glavni cilj NaSCEnT projekta je razvoj novog katalitičkog materijala nano-dimenzija (NKM), specifično razvijenog za učinkovito iskorištavanje Sunčeve energije u svrhu pročišćavanja vode i proizvodnje vodika. Sukladno tome, NKM će se pripremiti povezivanjem nanokompozitnih materijala sa poluvodičkim svojstvima na bazi TiO2, uz uključivanje SnS2, BiVO4, i ?-Fe2O3, te grafen oksida različitog stupnja redukcije (GO/rGO). Ciljana onečišćivala na kojima će se primijeniti solar/NKM sustav su farmaceutici, čiji su nusprodukti fotokatalitičke razgradnje niskomolekulske organske tvari koje mogu zamijeniti niskomolekulske alkohole koji se trenutno koriste u procesima fotoelektrokemijskog cijepanja vode. Optimiranje i procjena učinkovitosti solar/NKM sustava, uključujući okolišne, energetske i ekonomske aspekte, biti će provedena integriranjem računalnog i eksperimentalnog pristupa. Učinkovitost NKM-a će biti specifično podešavana kroz planirani dizajn i procedure sinteza, dok će se ugađanje ciljanih svojstava provesti pomoću modeliranja na molekularnoj razini. Rezultati NaSCEnT projekta imat će utjecaj na područja obrade vode i proizvodnje energije, te će utrti put ka primjeni nove, čiste i održive tehnologije.]]></summary_hr><summary_en><![CDATA[Accessible energy resources and clean water are nowadays among the highest priorities sustaining economic growth and societal wellbeing. Although the interdependency of energy and water is well known, the related technologies are still not sufficiently integrated. The groundbreaking idea of NaSCEnT project is to produce the clean energy while cleaning the water thus creating the shift of water-energy nexus paradigm. The underlying mechanism of photocatalytic processes for water purification and photoelectrochemical processes for energy conversion is basically the same. Both H2 production by water splitting and photocatalytic degradation of organic pollutants in water rely on the formation of electron/hole (e-/h+) pairs at a semiconducting material upon its excitation by the light with sufficient photon energy. The main goal of NaSCEnT is to develop novel nano-sized catalyst material (NCM) tailored to effectively harvest solar irradiation for simultaneous solar driven water purification and H2 production. Accordingly, NCM will be prepared by coupling semiconducting composites, made of TiO2 and semiconducting materials (SnS2, BiVO4, and ?-Fe2O3), and graphene oxide and its reduced form (GO/RGO). The NaSCEnT targets treatment of water polluted by pharmaceuticals. Their byproducts, low C-atom species, may mimic the role of lower C-atom alcohols, commonly used in H2 production in sole water splitting. The optimization and evaluation of solar/NCM system effectiveness, comprehending ecological, energetic and economic aspects will be performed integrating modeling and experimental approaches. The performance of NCM will be tailored through the planed design and development procedures. Fine tuning of the particular properties will be assisted by modeling at the molecular scale, thus minimizing the risk of the failure. The NaSCEnT results will address both water and energy fields and pave the way toward the application of innovative, clean and sustainable technologies.]]></summary_en></project><project>
<id>9470</id><title_hr><![CDATA[The use of nitrogen and oxygen stable isotopes in the determination of nitrate origin in the unsaturated and saturated zone of the Velika Gorica well field]]></title_hr><title_en><![CDATA[]]></title_en><user_id>26527</user_id><user_firstLast_name>Jelena Parlov</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-1212</code><acronim><![CDATA[]]></acronim><duration>05.10.2020 - 04.10.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Rudarstvo, nafta i geološko inženjerstvo, </scie_field_hr><scie_field_en>Mining, petroleum and geological engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Rudarsko-geološko-naftni fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mining, Geology and Petroleum Engineering]]></institution_en><team_members_id>856256</team_members_id><team_members_names><![CDATA[ Doktorand: Patricia Buškulić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>9472</id><title_hr><![CDATA[Formuliranje, priprema i testiranje biopolimernih gelova kao nositelja bioaktivnih i hlapljivih komponenata u inovativnim funkcionalnim proizvodima]]></title_hr><title_en><![CDATA[]]></title_en><user_id>7246</user_id><user_firstLast_name>Mirela Kopjar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-4205</code><acronim><![CDATA[bioACTIVEgels]]></acronim><duration>01.10.2020 - 30.09.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Prehrambena tehnologija, </scie_field_hr><scie_field_en>Food technology, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Prehrambeno-tehnološki fakultet]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Food Technology]]></institution_en><team_members_id>856299</team_members_id><team_members_names><![CDATA[ Doktorand: Ina Ćorković ]]></team_members_names><keywords_hr><![CDATA[Biopolimerni gelovi, bioaktivne komponente, hlapljive komponente, mikrovalovi, trehaloza, inovativni proizvodi]]></keywords_hr><keywords_en><![CDATA[Biopolymer gels, bioactive compounds, volatile compounds, microwave, trehalose, innovative products]]></keywords_en><summary_hr><![CDATA[Gelovi imaju široku primjenu, koriste se u proizvodnji prehrambenih proizvoda, farmaceutskih i različitih neprehrambenih proizvoda. Tradicionalni prehrambeni gelovi koji se najčešće proizvode, ali i koriste, su džemovi, marmelade, želei, slatkiši, voćni namazi, voćna punila. Osim u pripremi tradicionalnih proizvoda, gel-strukture se mogu formirati pomoću biopolimera s ciljem uklapanja i enkapsulacije bioaktivnih sastojaka i hlapljivih komponenata (ciljanih komponenata u ovom projektu). Tako dobivene gel-strukture mogu se koristiti za razvoj inovativnih, funkcionalnih proizvoda. Uz poboljšanje tradicionalnih prehrambenih gelova, istraživanja ćemo usmjeriti i na razvoj novih tzv. hidrogelova kao nositelja ciljanih komponenata. I bioaktivne i hlapljive komponente su vrlo važne za kvalitetu voća i proizvoda od voća obzirom da su odgovorne za boju, aromu, antioksidacijsku aktivnost te posjeduju potencijalni pozitivni učinak na zdravlje. Najveći problem je njihova nestabilnost. Hidrogelovi mogu biti vrlo korisni u razvoju tzv. „delivery by design“ koncepta jer tvore mrežu koja može fizički i/ili kemijski zarobiti bioaktivne i hlapljive komponente a isključujući dehidrataciju (popularnu za njihovu enkapsulaciju) koja može biti vrlo skupa. Oba tipa gelirani proizvoda pripremat će se od prehrambenih biopolimera. Biopolimeri mogu biti različitih struktura i fizikalno-kemijskih svojstava (npr. molekulske mase, naboja, razgranatosti, fleksibilnosti, polarnosti, topljivosti) te ovisno o svojstvima dolazi do njihovog povezivanja u koloidalne čestice koje mogu imati različita funkcionalna svojstva. Pažljivi odabir i balansiranje odgovarajućih biopolimera, sastav matriksa i metode pripreme, omogućuju formuliranje novih proizvoda odgovarajućih svojstava. Za pripremu gelova korist će se polisaharidi i/ili proteini. Dodatno, kako bi se postigla stabilnost bioaktivnih i hlapljivih komponenata korist će se tretiranje mikrovalovima (blagi proces) i dodatak trehaloze (stabilan šećer). ]]></summary_hr><summary_en><![CDATA[Gels have broad field of applications, from food products to pharmaceuticals, medicinal and non-food products. Traditional food gels that are very often prepared and used are jams, marmalades, jellies, sweets, fruit spreads, fruit fillings. Next to traditional application, gel-like structures can be formed by some biopolymers with the aim of inclusion and encapsulation of bioactive ingredients and volatile compounds (targeted compounds in this project), making them very attractive for immobilization of those compounds for development of innovative functional foods. Next to improvement of traditional gel products, we will concentre on development of hydrogels as delivery systems of targeted compounds. Both, bioactive and volatile compounds are very valuable for quality of fruit and fruit products since they are responsible for colour, flavour, antioxidant activity and poses health benefits. The major problem is their instability. Hydrogels could be quite useful for further growth of “delivery by design” concept, since they form network that can physically and/or chemically entrap bioactive and volatile compounds excluding dehydration step (popular tool for their encapsulation) that can be quite expensive. Both type of gelled products will be prepared with food biopolymers. Food biopolymers are having a diverse range of molecular and physicochemical properties (e.g. molecular weight, charge, branching, flexibility, polarity, solubility) allowing association of colloidal particles which have a broad range of functional attributes. Through careful selection and balancing of appropriate biopolymers, matrix composition and association methods, novel products with desired properties and behaviour can be formulated. For preparation of gel-structured products, polysaccharides and/or proteins will be used. Additionally, in order to improve stability of bioactive and volatile compounds, microwave treatment as mild process and/or trehalose as stable sugar will be applied. ]]></summary_en></project><project>
<id>9475</id><title_hr><![CDATA[Mjeriteljska infrastruktura za potporu inteligentnoj energetskoj mreži]]></title_hr><title_en><![CDATA[]]></title_en><user_id>142</user_id><user_firstLast_name>Marko Jurcevic</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-7731</code><acronim><![CDATA[INTELIGRID]]></acronim><duration>01.10.2020 - 01.10.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>858409</team_members_id><team_members_names><![CDATA[ Doktorand: Marko Kovačić ]]></team_members_names><keywords_hr><![CDATA[inteligentna energetska mreža, mjeriteljstvo, precizne mjerne metode, mjerenje snage, mjerenje energije, algoritmi obrade signala, PMU, sinkrofazor]]></keywords_hr><keywords_en><![CDATA[intelligent grid, metrology, precise measurement methods, measurement of power, measurement of energy, DSP algorithms, PMU, synchrophasor ]]></keywords_en><summary_hr><![CDATA[Opskrba električnom energijom iz obnovljivih izvora energije nije stabilna zbog same prirode izvora energije koji koriste. Ukoliko se takvi izvori pažljivo ne mjere i neprekidno nadziru, sve veća primjena takvih izvora dovesti će do smanjenja kvalitete električne energije, nestabilnosti elektroenergetskog sustava (EES) s mogućnošću povremenih raspada sustava i prekida u isporuci električne energije.Glavni ciljevi projekta predstavljaju:1) izrada i ispitivanje algoritama obrade mjerenja signala dobivenih s mreže PMU uređaja raspoređenih u EES-u,2) razvoj istraživačkog modela i prototipa uređaja PMU,3) razvoj sustava za ispitivanje i umjeravanje jedinica PMU primjenjivog u laboratoriju te kasnije u izvedbi prikladnoj za primjenu za udaljeno ispitivanje i umjeravanje.Predvidivo je načiniti algoritam (tj. grupu algoritama) za obradu podataka o kvaliteti električne energije i stanju EES-a (podacima o naponu, struji, frekvenciji i fazi) koje prikupljaju jedinice PMU, a koji se izvode na ugradbenim računalima te moraju imati brži odaziv od postojećih. Osim toga, cilj je, primjenom evolucijskih algoritama, načiniti algoritam koji će moći u skoro pa stvarnom vremenu locirati izvore nestabilnosti EES-a temeljem podataka dobivenih iz mreže PMU-ova. Predviđena izrada dvaju prototipova jedinica PMU što će omogućiti ispitivanje razvijenih mjernih algoritama na stvarnim modelima uređajima (dakle ne isključivo u računalnim simulacijama), a omogućiti će i ispitivanje sustava za umjeravanje jedinica PMU.Očekivani učinak istraživanja nalazi se u konkretnim znanstvenim doprinosima modernom načinu nadzora, zaštite i upravljanja EES-om, a koji je temeljen na mjernim podacima dobivenima s jedinica PMU (sinkrofazorima) u stvarnom vremenu. Tako će ovako zamišljen projekt predstavljati zaokruženu istraživačku cjelinu dosadašnjeg rada istraživačkih grupa, te povećati konkurentnost hrvatskih stručnjaka u svjetskim istraživačkim krugovima u navedenom području.]]></summary_hr><summary_en><![CDATA[Supply from renewable energy sources is unstable considering the source of the energy they convert. If those sources are left unsupervised and unchecked, the increase of their use will result in deterioration of power quality (PQ), instability of electric power system (EPS) with the possibility of situational system failure and disruption of the electrical energy distribution system.The main goals of the project are:1)	designing and testing an algorithm for processing of signals obtained from PMU units, and signals obtained from a PMU device network deployed in the EPS,2)	development of the research model and prototype of the PMU,3)	development of a system for testing and calibration of PMU units applicable in the laboratory and later on, in a form suitable for remote testing and calibration.It is envisaged to create a group of algorithms for processing data on the quality of electrical energy and state of the EPS (voltage, current, frequency, phase) coming from many PMU units, which are performed on embedded computers and must have a faster response than the existing ones. Additionally, using evolutionary algorithms, the goal is to create algorithms that will be able to locate instances of EPS instability in near real-time.It is envisaged to produce two PMU prototypes that will enable testing of developed measurement algorithms on real devices (ie not exclusively in computer simulations), and will also enable testing of the PMU calibration system.The expected impact of the research lies in concrete contributions to the modern way of monitoring, protecting and managing EPS, based on the metering data obtained from PMU units (synchrophazors) in real time. This activity will also provide the basis for new research in the area of monitoring and measurement of components in EPS, which will be funded from future projects. This way, the proposed project will represent the completion of the previous research as well as future planned work of research groups. ]]></summary_en></project><project>
<id>9478</id><title_hr><![CDATA[Utjecaj interneta i internetskih društvenih mreža na stavove i odluke o cijepljenju]]></title_hr><title_en><![CDATA[]]></title_en><user_id>19114</user_id><user_firstLast_name>Željko Pavić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-8413</code><acronim><![CDATA[INTERVAKC]]></acronim><duration>01.10.2020 - 01.04.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Sociologija, </scie_field_hr><scie_field_en>Sociology, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>856212</team_members_id><team_members_names><![CDATA[ Doktorand: Emma Kovačević ]]></team_members_names><keywords_hr><![CDATA[cijepljenje; antivakcinacijski pokret, Internet, internetske društvene mreže, znanstvena pismenost, sociokulturne promjene   ]]></keywords_hr><keywords_en><![CDATA[vaccination, antivax movement, Internet, Internet social networking sites, scientific literacy, socio-cultural changes]]></keywords_en><summary_hr><![CDATA[Unatoč verificiranim koristima, rašireno je odbijanje cijepljenja kao javnozdravstvene intervencije. Stoga je Svjetska zdravstvena organizacij otpore cijepljenju proglasila jednom od deset najvećih zdravstvenih prijetnji u 2019. godini. Uzroci otpora cijepljenju multidimenzionalni su te uključuju nisku razinu znanstvene pismenosti, sociokulturne vrijednosti i racionalni izbor. Rast upotrebe interneta pojavljuje se kao mehanizam koji pojačava te procese. Stoga je znanstveni cilj ovoga projekta istražiti moguće učinke interneta i internetskih društvenih mreža na stavove i odluke o cijepljenju. Teorijska je hipoteza da će internetska participacija biti povezana s negativnijim stavovima o cijepljenju, kao i da će negativni stavovi i ponašanje biti jače povezani s upotrebom interneta u usporedbi s upotrebom tzv. starih medija. Pri tome se pretpostavlja da će utjecaj medija biti posredovan razinom znanstvene pismenosti, manjim povjerenjem u institucije, odnosno postmodernim uvjerenjima o zdravlju. Medijacijski mehanizmi proizlaze iz teorijskog okvira koji obuhvaća komunikološke teorije (teoriju kultivacije), teorije u području znanstvene pismenosti (model deficita) te promjena sociokulturnih vrijednosti (Inglehartov model vrijednosnih promjena). Projekt tako integrira navedene teorije u jedinstven model. Provest će se četiri istraživanja (fokus grupe, analiza sadržaja, pilot istraživanje – N=500 i terensko anketno istraživanje na općoj populaciji RH – N=1.500). U istraživanjima će se upotrijebili validirane mjerne skale i posebno konstruirani instrumenti. Projekt će rezultirati objavom osam radova u Web of Science i Scopus publikacijama te sudjelovanjem na deset i organizacijom jedne konferencije. Projekt ima i izraženu javnozdravstvenu komponentu. Rezultati projekta sažet će se u priručnik koji bi se distribuirao liječnicima i drugim zainteresiranim javnostima. Rezultati projekta bit će predstavljeni i na konferencijama za medije i medijskim priopćenjima.]]></summary_hr><summary_en><![CDATA[Despite verified benefits, there is widespread rejection of vaccination as a public health intervention. The World Health Organization has declared vaccination as one of the top ten health threats in 2019. The causes of vaccine hesitancy are multidimensional and include low scientific literacy, socio-cultural values, and rational choice. Increasing internet usage seems to be a mechanism that enhances these processes. Therefore, the scientific aim of this project is to explore the possible effects of the Internet and Internet social networking sites on attitudes and decisions about vaccination. The project assumes that online participation will be associated with more negative attitudes about vaccination, and that negative attitudes and behaviors will be more strongly associated with the use of the Internet as compared to the use of so-called old media. It is assumed that the influence will be mediated by the scientific literacy, distrust of institutions, and postmodern health beliefs. Mediation mechanisms are derived from the theoretical framework that includes communication theories (theory of cultivation), theory of scientific literacy (the deficit model) and changes of sociocultural values (Inglehart&#39;s model of value changes). The project integrates these theories into a unique model. Four research (focus groups, content analysis, pilot study - N = 500 and field survey on the general population of Croatia - N = 1,500) will be conducted. Validated measurement scales and specially constructed instruments will be used. The project will result in the publication of eight papers in the Web of Science and Scopus indexed publications, participation in ten and the organization of one conference. The project also has a pronounced public health component. The results of the project will be summarized in a manual to be distributed to doctors and other interested citizens, and they will be presented at press conferences and through media releases and press conferences.]]></summary_en></project><project>
<id>9481</id><title_hr><![CDATA[Ekstrakcija bioaktivnih biljnih sastavnica pomoću zelenih otapala – korak prema zelenim kozmeceuticima]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4167</user_id><user_firstLast_name>Marijana Zovko Končić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-3280</code><acronim><![CDATA[CosmoGreen]]></acronim><duration>24.11.2020 - 01.04.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Farmacija, </scie_field_hr><scie_field_en>Pharmaceutical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Farmaceutsko-biokemijski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Pharmacy and Biochemistry]]></institution_en><team_members_id>858443</team_members_id><team_members_names><![CDATA[ Doktorand: Lejsa Jakupovic ]]></team_members_names><keywords_hr><![CDATA[Anti-aging, fibroblasti, izolacija vođena bioaktivnošću, kozmeceutici, optimizacija ekstrakcije, zelena otapala]]></keywords_hr><keywords_en><![CDATA[Anti-aging, bioactivity guided isolation, cosmeceuticals, extraction optimization, fibroblasts, green solvents]]></keywords_en><summary_hr><![CDATA[Mnogobrojne biljne sastavnice mogu utjecati na različite mete u ljudskom organizmu, uključujući stanice kože i ekstracelularni matriks. Na taj način one mogu djelovati ne samo na izgled nego i na zdravlje ovog važnog organa. Zbog toga se biljni ekstrakti često koriste u izradi takozvanih &#39;&#39;kozmeceutika&#39;&#39;, proizvoda za koje se smatra da imaju značajke kozmetike i lijekova. Prirodno porijeklo sastavnica takvih proizvoda, što uključuje i aktivne i pomoćne tvari, vrlo je poželjno. Stoga bi otapala koja se koriste za ekstrakciju biljnog materijala trebala biti prirodnog porijekla, biorazgradiva i netoksična. Nadalje, postupak ekstrakcije trebao bi biti usmjeren k povećanju sadržaja aktivne tvari u ekstraktima. Također je poželjno da otapalo ne bude samo pasivni nosač aktivne tvari nego i da učinkovito povećava njezinu djelotvornost. U sklopu projekta biti će priređena serija ekstrakata kopnenih i morskih organizama. Izolirat će se njihove aktivne sastavnice te odrediti njihova struktura. Biološka aktivnost ekstrakata bit će detaljno ispitana korištenjem više enzimskih testova te ispitivanja na stanicama. Odredit će se optimalni uvjeti ekstrakcije aktivnih tvari. Rezultati projekta bit će primjenjivi u razvoju kozmetičkih i dermatoloških proizvoda. Imajući na umu da će dio biljnog materijala koji će se koristiti u istraživanju biti dobiven iz otpadne biomase, rezultati će imati značajan ekonomski i ekološki potencijal  za proizvodnju kozmetike iz obnovljivih izvora. ]]></summary_hr><summary_en><![CDATA[Numerous plant secondary metabolites can affect multiple targets in human body, including skin cells and extracellular matrix. In this way, they can influence not only look, but also overall health of this important organ. For this reason plant extracts are often part of so-called “cosmeceuticals”, products combining the principles of cosmetics and drugs. Natural origin of such products&#39; ingredients, including both the active principles and the excipients, is highly valued. Therefore, the solvent used for the extraction of plant material should be of natural origin, biodegradable and non-toxic. Furthermore, the extraction process should be aimed at increasing the content of the active ingredient in the extract. Finally, it is desirable that the solvent is not only a passive carrier of the bioactive molecule but that it effectively enhances its desired activity. In the course of the project, a series of extracts from both terrestrial and marine organisms using non-toxic solvents of natural origin will be prepared. Their active constituents will be isolated, their structure determined and the biological activity thoroughly tested using several enzyme and cellular assays. Optimal conditions for the &#39;&#39;green&#39;&#39; extraction of active principles will be determined. The findings of this project will be applicable in development of cosmetic and dermatological products. Having in mind that the part of plant material used for the extraction will be obtained from waste biomass, the results will have a significant economical and ecological potential for production of cosmetics from renewable sources.]]></summary_en></project><project>
<id>9483</id><title_hr><![CDATA[Zeleni modularni putnički brod za Mediteran]]></title_hr><title_en><![CDATA[]]></title_en><user_id>252</user_id><user_firstLast_name>Nikola Vladimir</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-5176</code><acronim><![CDATA[ZEMP / GRiMM]]></acronim><duration>01.11.2020 - 31.10.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Brodogradnja, </scie_field_hr><scie_field_en>Naval architecture, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>858374</team_members_id><team_members_names><![CDATA[ Doktorand: Ivana Jovanović ]]></team_members_names><keywords_hr><![CDATA[putnički brod, modularni pristup, hidrodinamičke značajke, energetska učinkovitost, buka, vibracije ekološka prihvatljivost]]></keywords_hr><keywords_en><![CDATA[passenger vessel, modular approach, hydrodynamic characteristics, energy efficiency, noise, vibrations, environmental impact]]></keywords_en><summary_hr><![CDATA[Svrha projekta „Zeleni modularni putnički brod za Mediteran – ZEMP“ je razvoj nove metodologije projektiranja malih putničkih brodova namijenjenih za plovidbu Mediteranskim morem primjenom modularnog pristupa. Modularni pristup omogućava promjenu proizvodne paradigme od klasičnog pristupa u kojemu se sve komponente izrađuju u brodogradilištu prema paralelnoj proizvodnji različitih modula od strane kooperanata te završnoj montaži u brodogradilištima. Predviđeno je da se putnički broj sastoji od tri modula koji će činiti trup broda, brodski energetski sustav i nadgrađe. Kombinacijom tih modula mijenjat će se karakteristike broda, kao što su dimenzije, kapacitet, propulzijske značajke, pogonsko gorivo i razne inovativne energetski učinkovite tehnologije. Dakako, ovakav pristup povećava složenost procesa projektiranja jer je već u fazi projektiranja modula potrebno uzeti u obzir mnoštvo različitih značajki kojima koncepti trebaju udovoljavati, kao i pripadajući regulatorni okvir.U sklopu projekta najprije će biti provedena analiza tržišta za razna područja plovidbe unutar Mediterana kako bi se mogle odrediti potrebe kojima putnički brodovi trebaju udovoljiti. Na temelju toga će biti predloženo nekoliko preliminarnih koncepata, dok će finalni koncepti biti razvijeni uzimajući u obzir i sve druge aspekte projektiranja: hidrodinamičke i propulzijske značajke, jednostavnost procesa izrade, razinu ugode za putnike i posadu, kao i ekološki prihvatljiva rješenja energetskog sustava. Na temelju kriterija za pojedine namjene odabrat će se optimalni koncepti malog putničkog broda. Projekt će rezultirati predloženim konceptima koji će, ovisno o potrebama tržišta, imati niže troškove proizvodnje, povećanu razinu ugode za putnike i posadu, smanjenu potrošnju goriva i smanjeni utjecaj na okoliš.]]></summary_hr><summary_en><![CDATA[The objective of the project “Green Modular Passenger Vessel for Mediterranean – GRiMM” is the development of the new design methodology for small passenger ships aimed for the operation in the Mediterranean Sea, by applying the modular concept approach. The modular concept enables the change of the ship production paradigm from the classical all-in-one approach to a parallel manufacture of different components done by highly specialized producers and a final assembly done by the local shipyard. The target vessel is considered as made of independent modules which can be combined together to achieve different characteristics in terms of ship dimensions, carrying capacity, operating conditions, fuel options and innovative energy efficient solutions. Fundamentally, the ship is made of three modules forming the ship hull, power system and superstructure. Of course this approach makes the design process much more complex than that for a single specific ship, as it has to account for all the different needs and for the associated regulatory aspects.First, an analysis of the market needs and of the corresponding ship requirements will be performed for different navigation regions in the Mediterranean Sea. Preliminary concepts based on that analysis will be proposed, while the final concepts will be developed taking into account all the aspects of ship design: hydrodynamic and propulsion efficiency, simplified manufacturing processes, ship habitability (comfort level for crew and passengers) as well as environmentally friendly energy solutions. Through this project several optimized modular passenger vessels will be proposed depending on the selected design criteria sets. In this sense it is expected that the project will result in a number of concepts depending on the market needs with reduced production costs, higher level of comfort for crew and passengers, reduced fuel consumption as well as lower environmental impact.]]></summary_en></project><project>
<id>9484</id><title_hr><![CDATA[Hrv. - „Razvoj tehnologije za procjenu autopurifikacijskih sposobnosti priobalnih voda“; Eng. - CAAT – „Coastal Autopurification Assessment Technology“]]></title_hr><title_en><![CDATA[]]></title_en><user_id>7099</user_id><user_firstLast_name>Roko Andricevic</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-1176</code><acronim><![CDATA[]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Građevinarstvo, </scie_field_hr><scie_field_en>Civil engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu Fakultet građevinarstva, arhitekture i geodezije]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Civil Engineering, Architecture and Geodesy]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>9485</id><title_hr><![CDATA[ZBRINJAVANJE PROČIŠĆENIH ZAULJENIH OTPADNIH VODA I MULJA S UPOV-A U OPEKARSKOJ INDUSTRIJI – PROIZVODNJA NOVOG OPEKARSKOG PROIZVODA U OKVIRU KRUŽNE EKONOMIJE]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5991</user_id><user_firstLast_name>Dražen Vouk</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-4363</code><acronim><![CDATA[BRAVOBRICK]]></acronim><duration>12.10.2020 - 11.10.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Građevinarstvo, </scie_field_hr><scie_field_en>Civil engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Građevinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Civil Engineering]]></institution_en><team_members_id>26308</team_members_id><team_members_names><![CDATA[ Doktorand: Anđelina Bubalo ]]></team_members_names><keywords_hr><![CDATA[zauljene otpadne vode,mulj,UPOV,elektrokemijski procesi,termička obrada,opeka,inovativni materijali,kružna ekonomija]]></keywords_hr><keywords_en><![CDATA[oily wastewater,sewage sludge,WWTP,electrochemical processes,thermal treatment,brick,innovative materials,circular economy]]></keywords_en><summary_hr><![CDATA[Konvencionalni postupci pročišćavanja zauljenih otpadnih voda su skupi pa se javlja potreba za razvojem novih tehnologija s nižim troškovima i mogućnošću materijalne oporabe pročišćene vode. Pročišćavanjem otpadnih voda, općenito, generira se nova vrsta otpada - mulj. S naglim porastom izgradnje UPOV-a problem zbrinjavanja mulja dobiva na težini. Mogućnost materijalne oporabe mulja ovisi o njegovu sastavu pa istraživanja s muljevima čiji se sastav razlikuje od onih generiranih na području Hrvatske treba uzeti s oprezom. Materijalnom oporabom mulja u građevinskoj industriji (proizvodnji opeke) mulj zamjenjuje dio prirodnog resursa (gline ili pijeska), čime se smanjuju pritisci na okoliš.Cilj istraživanja je pročistiti zauljene otpadne vode primjenom hibridnog elektrokemijskog procesa do kakvoće da se mogu učinkovito koristiti kao tehnološke vode u proizvodnji opeke te na temelju ispitivanja tehnoloških parametara optimizirati proces i minimizirati operativne troškove. Korištenje pročišćene vode, ulazi u okvire kružne ekonomije s mogućnošću dobivanja jeftinijih opeka, konkurentnijih na tržištu. Ispitat će se mogućnost korištenja mulja s UPOV-a (termički obrađenog) u opekarskoj industriji, a poseban doprinos bit će ispitivanje učinkovitosti sušenja mulja mikrovalovima. Neovisno o rezultatima na opeki, ovaj dio istraživanja primjenjiv je i šire, prvenstveno u obradi mulja s ciljem dobivanja što manjih količina higijeniziranog mulja. Postavit će se metodologija procjene tehničko-ekoloških utjecaja mulja i pepela iz mulja u proizvodnji opeke i definirati utjecaj kemijskog sastava i mikrostrukture mulja i pepela na svojstva gotovih proizvoda. Ispitivanjem izluživanja odredit će se njihova prikladnost za korištenje u okolišu.Rezultati istraživanja od interesa su za područje vodnog gospodarstva s ciljem zbrinjavanja zauljenih otpadnih voda i mulja s UPOV-a i za industriju proizvodnje građevnih materijala s ciljem smanjenja korištenja sirovina iz prirode, ali i emisija CO2.]]></summary_hr><summary_en><![CDATA[Conventional oily wastewater treatment is expensive so there is a need for new cheaper technologies and the possibility of material recovery of treated water. Wastewater treatment in general generates new waste - sludge. With the increase in the construction of WWTPs, this problem is even more important. The potential for material recovery of the sludge depends to a great extent on its composition, so results with sludge which composition differs from those generated in Croatia should be taken with caution. The material recovery of sludge in the construction industry (brick production) replaces part of the natural resources (clay or sand), thereby reducing environmental stresses.The aim of this research is to treat the oily wastewater using a hybrid electrochemical process, so it can be applied as technological water in brick industry, and to optimize the process and minimize operating costs by examining technological parameters. The use of treated water contributes to the circular economy with the possibility of obtaining cheaper, more competitive bricks. The possibility of using sludge in the brick industry will be investigated, and a special contribution will be to examine the efficiency of sludge drying by microwaves. Regardless of the results on the bricks, this part of the research is applicable even more widely, primarily in sludge treatment to obtain as little as possible of hygienic sludge. The methodology for assessing technical and ecological impacts of sludge/ash in brick production will be established and the influence of chemical composition and microstructure of sludge/ash on the properties of final products will be defined. Testing the leaching will determine its suitability for use in the environment.The research results are of interest to the water management sector with the aim of disposing of oily wastewater and sludge and for the construction materials industry with the aim of reducing the use of raw materials, but also reducing CO2 emissions.]]></summary_en></project><project>
<id>9486</id><title_hr><![CDATA[Platforma za satelitsko mjerenje elektromagnetskog zračenja]]></title_hr><title_en><![CDATA[]]></title_en><user_id>7148</user_id><user_firstLast_name>Dubravko Babic</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-3211</code><acronim><![CDATA[CROSPERITY]]></acronim><duration>12.01.2021 - 12.01.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>864988</team_members_id><team_members_names><![CDATA[ Doktorand: Jakov Tutavac ]]></team_members_names><keywords_hr><![CDATA[piko-sateliti, cubesat, geomagnetsko polje, svjetlosno zagađenje, promatranje Zemlje]]></keywords_hr><keywords_en><![CDATA[pico-satellite, cubesat, geomagnetic field, light pollution, Earth observation]]></keywords_en><summary_hr><![CDATA[Plan ovog projektnog prijedloga je razvoj platforme za satelitsko mjerenje elektromagnetskih emisija sa zemlje i iz svemira. Razvijena platforma će biti demonstrirana implementacijom (i) novog ultraljubičastog fotodetektora na temelju elementarnog bora (engl. pure B) u svrhu demonstracije robusnosti i primjenjivosti ovog tipa detektora na svemirske uvjete, (ii) sustava za spektralno razlučenje svjetla u svrhu identifikacije svjetlosnih izvora u svrhu praćenja razvoja svjetlosnog zagađenja sa Zemlje, tj. zamjene električnih žarulja i fluorescentnog osvjetljenja svjetlećim diodama, i (iii)  sustavom za mjerenje geomagnetskog polja u svrhu identifikacije fenomena koji utječu na navigaciju i praćenje satelita. Visina sa koje će se opservacije voditi je oko 600 km, a područje mjerenja bit će globalno.  U sklopu ovog projekta, razvit će se piko-satelit volumena 1 litre i težine 1 kg (CubeSat) koji će biti prilagođen za navedenu mjernu platformu.]]></summary_hr><summary_en><![CDATA[The purpose of this project is the development of a characterization platform for the measurement of electromagnetic emissions from Earth and space. The developed platform shall be demonstrated using (i) a novel ultraviolet photodetector based on pure Boron with the aim to demonstrate the robustness the technology and its suitability for space applications, (ii) a system for spectral resolving of light emitted from the earth to monitor light pollution and the global installation of light-emitting diodes in public places, and (iii)  a system  for monitoring of geomagnetic field which influences the navigation and tracking of satellites. The elevation from which these observations will be made is around 600 km above earth and the measurements will be global (entire earth).  This project plans to develop a pico-satellite with volume 1 liter and 1 kg weight, also known as the CubeSat, that will be customized to perform these functions. ]]></summary_en></project><project>
<id>9487</id><title_hr><![CDATA[Development and Validation of a Surface Wear Model for Mixed Mode Lubricated Contact]]></title_hr><title_en><![CDATA[]]></title_en><user_id>240</user_id><user_firstLast_name>Hrvoje Jasak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-3846</code><acronim><![CDATA[]]></acronim><duration>01.10.2020 - 01.10.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, </scie_field_hr><scie_field_en>Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>858317</team_members_id><team_members_names><![CDATA[ Doktorand: Luka Balatinec ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>9488</id><title_hr><![CDATA[Nutritivna i funkcionalna vrijednost koprive (Urtica dioica L.) primjenom suvremenih hidroponskih tehnika uzgoja]]></title_hr><title_en><![CDATA[]]></title_en><user_id>23516</user_id><user_firstLast_name>Sanja Radman</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-6368</code><acronim><![CDATA[URTICA-BioFuture]]></acronim><duration>21.10.2020 - 20.10.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Agronomski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Agriculture]]></institution_en><team_members_id>856289</team_members_id><team_members_names><![CDATA[ Doktorand: Nevena Opačić ]]></team_members_names><keywords_hr><![CDATA[kopriva, hidroponski uzgoj, vodni stres, specijalizirani metaboliti, antioksidacijska aktivnost ]]></keywords_hr><keywords_en><![CDATA[nettle, hydroponic cultivation, drought stress, specialized metabolites, antioxidant activity]]></keywords_en><summary_hr><![CDATA[Kopriva je višegodišnja biljka bogata fitokemikalijama i specijaliziranim metabolitima (SM), što ju svrstava u kategoriju biljaka velikog potencijala i široke primjene. Iako raste samoniklo u prirodi, teži se njenoj kultivaciji u svrhu dobivanja gotovog proizvoda ujednačenog kemijskog sastava. Odabranim agrotehničkim mjerama tijekom fenofaza u razvoju biljke značajno se može utjecati na sintezu i akumulaciju SM, koji su pod izravnim utjecajem brojnih biotskih, abiotskih i antropogenih čimbenika. Ključni čimbenici za dobivanje nutritivno kvalitetnog proizvoda adekvatnog prinosa uključuju balansiranu gnojidbu, fenofazu razvoja i dinamiku košnje. Sve evidentnije klimatske promjene potenciraju implementaciju suvremenih metoda uzgoja. Suvremene tehnike proizvodnje povrća podrazumijevaju hidroponski uzgoj koji pokazuje niz prednosti: dobro gospodarenje prirodnim resursima, racionaliziranu potrošnju vode zbog recirkulacije hranive otopine, sprječavanje gubitka hraniva iz rizosfere, kontrolu abiotskih čimbenika hranive otopine te zraka. Prilikom plasmana proizvoda na tržište, a u svrhu što duljeg očuvanja nutritivnih i organoleptičkih kvaliteta te trajnosti proizvoda, nužno je pakiranje istog s ciljem smanjenja kontakta svježe koprive s atmosferom okoliša. Ključni čimbenici prilikom pakiranja su odabir adekvatnog ambalažnog materijala i sastav plinova u pakiranjima. Pakiranje u modificiranoj atmosferi značajno usporava degradaciju nutritivnih svojstva svježe ubrane biljke uz osiguravanje mikrobiološke ispravnosti pakiranog proizvoda.]]></summary_hr><summary_en><![CDATA[Nettle is a perennial plant rich in phytochemicals and specialized metabolites (SM), often categorized as a product of great potential and wide usage. Although wild nettle is widespread in nature, its cultivation is necessary in order to achieve known chemical composition of final product. Agro-technical measures during different phases in plant&#39;s development can considerably impact the synthesis and accumulation of SM, which are directly influenced by numerous biotic, abiotic and anthropogenic factors. Key factors for obtaining a nutritive high quality product of adequate yield include balanced fertilization, plant development stage and harvest period. More evident climatic changes encourage the implementation of modern growing methods. Modern vegetables growing methods include hydroponic cultivation which shows number of advantages: good natural resources management, rationalized water consumption because of nutrient solution recirculation, preventing loss of nutrients from the rhizosphere, control of abiotic factors of nutrient solution and air. During the product market placement with an aim of longer nutritive and organoleptic qualities preservation and durability of the product it is necessary to pack the product with a goal to reduce the contact of fresh nettle with the surrounding atmosphere. Key factors during packaging are selection of adequate packaging material and gases composition in package. Packaging in a modified atmosphere significantly reduces the degradation of nutritional properties of fresh plant material while ensuring the microbiological safe of the packaged product.]]></summary_en></project><project>
<id>9489</id><title_hr><![CDATA[Frustrirani Kompleksni sustavi]]></title_hr><title_en><![CDATA[]]></title_en><user_id>26810</user_id><user_firstLast_name>Salvatore Marco Giampaolo</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-9938</code><acronim><![CDATA[FCS]]></acronim><duration>09.02.2021 - 08.08.2026</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>865286</team_members_id><team_members_names><![CDATA[ Doktorand: Sven Benjamin Kožić ]]></team_members_names><keywords_hr><![CDATA[Frustracija, kompleksni sustavi, kompleksne mreže, kvantna isprepletenost, kvantna faza tvari, sistemski rizik, režim jakog grupiranja]]></keywords_hr><keywords_en><![CDATA[Frustration, Complex systems, Complex Networks, Entanglement, Quantum phase of matter, Systemic risk, Strong Clustering regime]]></keywords_en><summary_hr><![CDATA[Poznato je da frustracija, odnosno nemogućnost pronalaženja konfiguracije koja istodobno zadovoljava različita ograničenja sustava više tijela, igra ključnu ulogu u mnogim aktualnimpodručjima teorijske fizike. Međutim, unatoč toj važnosti, detaljna analiza različitih učinaka frustracije nije nikada napravljena. Naš projekt, pod nazivom &#39;&#39;Složeni frustriranisustavi&#39;&#39;, ima za cilj provesti ovu analizu u tri različita polja od iznimne važnosti za statističku fiziku: nisko-dimenzionalni spin-1/2 sustavi, kvantna termodinamika i kompleksne mreže.Koristeći nedavno razvijene analitičke alate i najmodernije numeričke simulacije, cilj našeg rada je uvođenje različitih modela u kojima se stupanj frustracije može lako kontrolirati. Utim sustavima analizirat će se kako različite količine fizičkog porijekla reagiraju na varijacije frustracije i ako se njihovo pojavljivanje može smatrati osnovom pojave / nestanka određenih karakteristika sustava. Rezultati našeg istraživanja mogli bi odigrati temeljnu ulogu u području znanstvenog istraživanja, kako s teoretskog taki i primjenjenog gledišta. U teoriji, povećati će naše razumijevanje samoorganizirajućih sustava i dovesti do otkrivanja novih uređenih faza. Oni bi također mogli biti primjenjeni na tako različite sustave kao štosu: novi uređaji za kvantni račun ili smanjenje sistemskog rizika u financijskim sustavu.]]></summary_hr><summary_en><![CDATA[It is w ell-know n that frustration, that is the impossibility of finding a configuration that simultaneously satisfies the different constraints of a many-body system, plays a key role in many fields of current interest in theoretical physics. How ever, despite this importance, a detailed analysis of the different effects of frustration has never been made. Our project, called &#39;&#39;Complex frustrated systems&#39;&#39;, aims to carry out this analysis in three different fields of extreme relevance for statistical physics: low - dimensionality spin 1/2 systems, quantum thermodynamics and complex networks. Using recently developed analytical tools and cutting-edge numerical simulations, the goal of our work is to introduce different models in which the degree of frustration can be easily controlled. In these systems it w ill be analyzed how the different quantities of physical origin respond to the variation of frustration and if the emergence of the latter can be considered the basis of the appearance / disappearance of particular characteristics of the systems. The results of our study could play a fundamental role in the field of scientific research both from a theoretical and applicational point of view. In theory, it w ill help to increase our understanding of self-organized systems and lead to the discovery of new ordered phases. They could also be applied to such diverse systems such as: new devices for quantum computation, or reduction ofsystemic risk in financial systems.]]></summary_en></project><project>
<id>9495</id><title_hr><![CDATA[Utjecaj majčinog metaboličkog stanja na serotoninski sustav posteljice i neonatusa: od metilacije DNA do funkcije proteina]]></title_hr><title_en><![CDATA[]]></title_en><user_id>19126</user_id><user_firstLast_name>Sandra Nakić Radoš</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-4127</code><acronim><![CDATA[PLANS]]></acronim><duration>09.11.2020 - 09.02.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Psihologija, </scie_field_hr><scie_field_en>Psychology, </scie_field_en><institution_hr><![CDATA[Hrvatsko katoličko sveučilište, Zagreb]]></institution_hr><institution_en><![CDATA[Catholic University of Croatia]]></institution_en><team_members_id>861748</team_members_id><team_members_names><![CDATA[ Doktorand: Maja Žutić ]]></team_members_names><keywords_hr><![CDATA[serotonin, posteljica, krv iz pupkovine, metilacija DNA, gestacijski dijabetes]]></keywords_hr><keywords_en><![CDATA[serotonin, placenta, cord blood, DNA methylation, gestational diabetes]]></keywords_en><summary_hr><![CDATA[Serotonin (5HT) je multifunkcionalna signalna molekula, najpoznatija kao neurotransmiter središnjeg živčanog sustava. Osim toga, 5HT igra važne ekstracerebralne uloge, kako u odrasloj dobi tako i tijekom razvoja. Poremećaji 5HT homeostaze povezuju se s mnogim mentalnim zdravstvenim problemima, a pojavljuju se i kao važan čimbenik u pretilosti i dijabetesu. Sve više dokaza sugerira da metilacija DNA modulira ekspresiju 5HT-regulirajućih gena i da može doprinositi  serotoninskoj disfunkciji. Metilacija DNA je dinamičan proces osjetljiv na okolinske utjecaje, posebno tijekom ranog razvoja. Naši nedavni rezultati upućuju da je posteljična metilacija DNA gena za 5HT prijenosnik (SLC6A4), glavni regulator 5HT signalizacije, osjetljiva na majčine metaboličke nepravilnosti povezane s gestacijskim dijabetes melitusom (GDM). Ovaj projekt usmjeren je na daljnje razumijevanje utjecaja majčinog metaboličkog stanja u trudnoći na 5HT sustav posteljice i novorođenčeta. Korištenjem tkiva posteljice i primarnih stanice posteljice dobivenih iz klinički dobro definiranih zdravih i GDM trudnoća, istražit ćemo odnos majčine gestacijske glikemije i predgestacijskog indeksa tjelesne mase (pITM) s posteljičnom metilacijom i ekspresijom gena SLC6A4 i gena za 5HT receptor tipa 2A (HTR2A). Nadalje, studijama in vitro na humanim primarnim trofoblastima istražit ćemo kako izloženost glukozi utječe na metilaciju DNA i ekspresiju gena SLC6A4 te na funkciju odgovarajućeg genskog produkta (aktivnost unosa serotonina). Konačno, istražit ćemo odnos majčine glikemije i pITM s 5HT sustavom novorođenčeta, mjerenjem serotoninskih biokemijskih parametara (razina 5HT, aktivnost 5HT prijenosnika, agregacija trombocita) i metilacije DNA 5HT-regulirajućih gena u krvi iz pupkovine.]]></summary_hr><summary_en><![CDATA[Serotonin (5HT) is a multifunctional signaling molecule, the best known as the central nervous system neurotransmitter. In addition, 5HT plays important extra-cerebral roles, both in adulthood and during development. Disturbances in 5HT homeostasis have been linked to many mental health conditions and are emerging as an important contributor also to obesity and diabetes. Rising evidence suggests that DNA methylation modulates expression of 5HT-regulating genes and may contribute to 5HT dysfunction. DNA methylation is a dynamic process sensitive to environmental influences, particularly during early development. Our recent results suggest that placental DNA methylation of the 5HT transporter gene (SLC6A4), a principal regulator of 5HT signaling, is sensitive to maternal metabolic derangements associated with gestational diabetes mellitus (GDM). This project is aimed to further understand impact of maternal metabolic state in pregnancy on placental and newborn&#39;s 5HT system. Using placental tissue and  primary placental cells obtained from clinically well-defined healthy and GDM pregnancies, we will investigate relationship of maternal gestational glycaemia and pregestational body mass index (pBMI) with placental DNA methylation and expression of SLC6A4 and 5HT receptor type 2A (HTR2A) genes. In addition, by in vitro studies in human primary trophoblasts, we will investigate how exposure to glucose affects SLC6A4 DNA methylation and expression as well as function of the corresponding gene product (serotonin uptake activity). Finally, we will investigate relathionship of meternal glycemia and pBMI with newborn&#39;s 5HT system, by measuring 5HT-related biochemical parameters (5HT levels, platelet 5HT uptake, platelet aggregation) and DNA methylation of 5HT-regulating genes in umbilical cord blood.]]></summary_en></project><project>
<id>9499</id><title_hr><![CDATA[Razvoj sustava kontrole i obrane luka od unosa stranih vrsta – ProtectAS]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6656</user_id><user_firstLast_name>Goran Lončar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-6524</code><acronim><![CDATA[]]></acronim><duration>05.10.2020 - 04.04.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Građevinarstvo, </scie_field_hr><scie_field_en>Civil engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Građevinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Civil Engineering]]></institution_en><team_members_id>21305</team_members_id><team_members_names><![CDATA[ Doktorand: Tin Kulić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>9500</id><title_hr><![CDATA[Siguran pristup za razvoj nano-sustava za ciljanu isporuku lijekova u mozak - SENDER]]></title_hr><title_en><![CDATA[]]></title_en><user_id>12653</user_id><user_firstLast_name>Dinko Mitrečić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-2328</code><acronim><![CDATA[]]></acronim><duration>01.11.2020 - 31.10.2024</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>858430</team_members_id><team_members_names><![CDATA[ Doktorand: Ana Bekavac ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>9501</id><title_hr><![CDATA[Sustav potpore odlučivanju za zeleniju i sigurniju plovidbu brodova]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4256</user_id><user_firstLast_name>Jasna Prpić-Oršić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-1135</code><acronim><![CDATA[DESSERT]]></acronim><duration>03.10.2022 - 03.07.2026</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Brodogradnja, </scie_field_hr><scie_field_en>Naval architecture, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Tehnički fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Engineering]]></institution_en><team_members_id>865636</team_members_id><team_members_names><![CDATA[ Doktorand: Marijana Balas ]]></team_members_names><keywords_hr><![CDATA[sustav potpore odlučivanju, pomorstvenost, spektar valova, optimizacija rute, mjerenje, emisija stakleničkih plinova]]></keywords_hr><keywords_en><![CDATA[decision support system, seakeeping, wave spestra, route optimisation, measurements, greenhouse gases emissions]]></keywords_en><summary_hr><![CDATA[Cilj istraživanja u okviru projekta Sustav potpore odlučivanju za zeleniju i sigurniju plovidbu brodova (DESSERT) je razvoj učinkovitog sustava potpore odlučivanju (Decision Support System - DSS) kapetanima broda, kao i zapovjednicima stroja, a koji bi doprinio ”zelenijoj” i sigurnijoj plovidbi brodova. Krajnji učinak takvog DSS bilo bi svođenje ljudske pogreške na što manju mjeru, odnosno pružanje odgovornim osobama na brodu maksimalno vjerodostojne podatke i smjernice tijekom plovidbe kako bi se smanjilo onečišćenje okoliša i kako bi ljudi i teret bili što sigurniji. Istraživanja vezana uz razvoj DSS-a odvijat će se u dva osnovna smjera: energetski učinkovitija plovidba uz smanjenje emisije stakleničkih plinova; i povećanje sigurnosti plovidbe s aspekta izbjegavanja sudara i s aspekta pravovremenih reakcija u slučaju naplavljivanja broda.U okviru istraživanja planira se osmišljavanje, provedba i analiza upitnika (anketa) koji su namijenjeni kapetanima i upraviteljima stroja na brodovima. Namjera je dobivanje što vjerodostojnijih podataka o reakciji posade na pojedine dinamičke učinke uzrokovane pogoršanjem vremenskih uvjeta. Analizom anketa planira se dobiti povratne podatke o kriterijima i graničnim vrijednostima kriterija koji su mjerodavni za namjernu promjenu brzine ili kursa zbog pretjeranog njihanja broda na valovima, te razviti model “virtualnog kapetana” koji bi se koristio prilikom simulacije i planiranja rute plovidbe. Značajan znanstveni doprinos istraživanja vezan je za brodska pogonska postrojenja. Cilj je razviti sustav potpore odlučivanju na brodu uzimajući u obzir projektantsku, strojarsku i pomorsku ekspertizu u cilju stvaranja sigurnog i ekološki učinkovitog ili &#39;&#39;zelenijeg&#39;&#39; broda i plovidbe. Projektni tim sastoji se od znanstvenika koji su stručnjaci u brodogradnji, strojarstvu,  pomorskom inženjerstvu i računarstvu koji omogućuju multidisciplinarno rješavanje ovog problema.]]></summary_hr><summary_en><![CDATA[The goal of the research in a frame of project DEcision Support System for green and safE ship RouTing – DESSERT is the development of an effective Decision Support System (DSS) is planned for ship captains as well as machine commanders, which would contribute to &#39;&#39;greener&#39;&#39; and safer navigation of ships. The ultimate impact of such a DSS would be to make human error as small as possible, or to provide responsible persons on board the most credible data and guidance during navigation to reduce environmental pollution and make people and cargo safer.Research related to the development of DSS will take place in two main directions: energy-efficient navigation along with reduction of greenhouse gas emissions; and increase sailing safety by collision avoidance as well as from timely reactions in the event of flooding. Within the scope of the survey, the design, implementation and analysis of questionnaires (surveys) designed for captains and engineers on ships are planned. The intention is to get the most credible data on the crew response to the individual dynamic effects caused by the worsening of weather conditions. Survey analysis is designed to get feedback on the criteria and limit values of the criteria that are relevant to deliberate speed or course change due to excessive ship motions on waves, and to develop a &#39;&#39;virtual captain&#39;&#39; model to be used when simulating and planning the navigation route. Significant scientific contribution to research is related to ship propulsion plants. The objective is to develop decision support system on board taking into accounts the environmental issue, creating a so called safe and eco-efficient or “green” ship. The project team consists of the scientists who are experts in the naval architecture, mechanical engineering, marine engineering field and computational sciences which allow solving this problem multidisciplinary.]]></summary_en></project><project>
<id>9502</id><title_hr><![CDATA[Orkestracija hibridnih metoda umjetne inteligencije za računalne igre]]></title_hr><title_en><![CDATA[]]></title_en><user_id>891</user_id><user_firstLast_name>Markus Schatten</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-1470</code><acronim><![CDATA[O-HAI 4 Games]]></acronim><duration>02.11.2020 - 01.05.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Informacijske znanosti, </scie_field_hr><scie_field_en>Information sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet organizacije i informatike]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Organization and Informatics]]></institution_en><team_members_id>858355</team_members_id><team_members_names><![CDATA[ Doktorand: Tomislav Peharda ]]></team_members_names><keywords_hr><![CDATA[umjetna inteligencija, višeagentni sustavi, računalne igre, hibridne metode, ansambl metoda, hologramske igre]]></keywords_hr><keywords_en><![CDATA[artificial intelligence, multi-agent systems, computer games, hybrid methods, ensemble of methods, holographic games]]></keywords_en><summary_hr><![CDATA[Hibridne metode umjetne inteligencije koje predstavljaju uspostavu ansambla različitih simboličkih i statističkih metoda umjetne inteligencije radi postizanja što točnijeg rezultata, sveprisutne su u stručnoj i znanstvenoj literaturi. Ipak, metodologija razvoja takvih metoda uglavnom je ad-hoc i ovisi od projekta do projekta. Računalne igre od samih su početaka vezane uz područje umjetne inteligencije - od Shannonovog minmax algoritma za umjetnog igrača šaha 1949., do najnovijih postignuća poput AlphaGo sustava koji je pobijedio velemajstora u igri Go, igre su se pokazale kao izrazito plodno područje za razvijanje metoda umjetne inteligencije. S druge strane umjetna je inteligencija izrazito važna komponenta većine računalnih igara koje se često vrednuju i hvale korištenjem novih i inovativnih metoda umjetne inteligencije. Računalne igre omogućuju nam provjeru metoda umjetne inteligencije ne samo u svrhu zabave, već i u mnogim drugim područjima ljudskog djelovanja, o čemu svjedoče područja ozbiljnih igara i igrifikacije. U projektnoj prijavi predlaže se uspostavljanje novog okvira za orkestraciju hibridnih metoda umjetne inteligencije s posebnom primjenom na razvoj računalnih igara. U skladu s time razvila bi se ontologija i meta-model alata za stvaranje modela (ansambla) metoda umjetne inteligencije, razvila modularna distribuirana platforma za orkestraciju hibridnih metoda umjetne inteligencije te razvio niz modula hibridnih ansambla koji bi se testirala u četiri okružja računalnih igara: (1) MMORPG igre, (2) igrificirana okolina za učenje, (3) ozbiljna igra vezana uz autonomna vozila i (4) igra za holografsku/volumetrijsku igraću konzolu koja bi se također razvila u projektu.]]></summary_hr><summary_en><![CDATA[Hybrid artificial intelligence methods, which can be defined as the orchestration of complementary heterogeneous both symbolic and statistical AI methods to acquire more precise results, are omnipresent in contemporary scientific literature. Still, the methodology of developing such systems is in most cases ad-hoc and depends from project to project. Computer games have always been connected to the development of AI. From the earliest chess minmax algorithm by Claude Shannon in 1949 to the more recent AlphaGo in 2015, computer games provide an ideal testing environment for AI methods. Similarly, AI has always been an important part of computer games, which have often been judged by the quality of their AI and praised if they used an innovative approach. Computer games allow us to test AI methods, not only for fun and leisure, but also for numerous other fields of human activity through the fields of serious games and gamification. The project proposes to establish an new framework for the orchestration of hybrid artificial intelligence methods with a special application to computer games. Therefore an ontology of hybrid AI methods as well as a meta-model shall be developed that would allow for creating models (ensembles) of hybrid AI methods. This meta-model would be implemented into a modular distributed orchestration platform which would be further enriched with a number of modules to be tested in four gaming related environments: (1) MMORPG games, (2) gamified learning platform, (3) serious game related to autonomous vehicles and (4) a game for a holographic/volumetric gaming console which would also be developed during the projedt.]]></summary_en></project><project>
<id>9504</id><title_hr><![CDATA[Lipidi hrane, spol i dob u patogenezi metaboličkog sindroma]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5392</user_id><user_firstLast_name>Tomislav Mašek</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-6109</code><acronim><![CDATA[DietMetSyn]]></acronim><duration>20.10.2020 - 19.10.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Veterinarska medicina, </scie_field_hr><scie_field_en>Veterinary medicine, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Veterinarski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Veterinary Medicine]]></institution_en><team_members_id>857312</team_members_id><team_members_names><![CDATA[ Doktorand: Valentina Percan ]]></team_members_names><keywords_hr><![CDATA[Lipidi, metabolički sindrom, hrana, miRNA, kronična upala, rezistencija na inzulin]]></keywords_hr><keywords_en><![CDATA[Lipids, metabolic syndrome, food, miRNA, cronic inflammation, insulin resistence]]></keywords_en><summary_hr><![CDATA[Poremećaj metabolizma lipida ključna je komponenta u razvoju metaboličkog sindroma pa je i prevalencija metaboličkog sindroma povezana sa stupnjem pretilosti. Stoga, promjene u sastavu hrane mogu biti važna strategija za prevenciju metaboličkog sindroma i posljedičnih bolesti.Pretilost nastaje tijekom dugotrajne pozitivne energetske ravnoteže koja potiče proupalni odgovor. To uzrokuje kroničnu upalu i pojačani dotok lipida iz masnog tkiva u jetru, mišićno tkivo i gušteraču što rezultira s glukotoksičnosti i lipotoksičnosti. Kronična upala i rezistencija na inzulin danas su prepoznati kao bitni čimbenici kod mnogih bolesti kao što su dijabetes tipa 2, kardiovaskularne bolesti, Alzheimerove bolesti i tumora.Za postizanje ciljeva projekta istražit ćemo nekoliko interakcija važnih za patogenezu metaboličkog sindroma: A) utjecaj n3/n6 omjera lipida hrane i dodavanja DHA kao prevencije metaboličkog sindroma, B) utjecaj n3/n6 omjera lipida hrane i dodavanja DHA kao moguće terapije metaboličkog sindroma, C) prijenos sklonosti razvitku metaboličkog sindroma i prekomjerne tjelesne mase s roditelja na potomstvo kao i utjecaj prehrane potomstva na težinu poremetnji prije i nakon spolne zrelosti, D) interakciju između dobi i metaboličkog sindroma i E) metabolizam lipida u tumorskom tkivu i tumorske markere lipidnog porijekla kao moguću vezu između pretilosti, metaboličkog sindroma, kronične upale i tumora.Naposlijetku, podaci iz cijelog projekta rezultirat će integracijom stečenih znanja iz svih pokusa i boljem razumijevanju složenosti patogeneze metaboličkog sindroma. Integrativni pristup omogućit će nove pristupe prevenciji i liječenju metaboličkog sindroma putem modifikacije prehrane kao i bolje razumijevanje veze između kronične upale izazvane pretilošću i tumora.]]></summary_hr><summary_en><![CDATA[Dysfunction of lipid metabolism is a key component in the development of metabolic syndrome and the prevalence of metabolic syndrome is strongly associated with the severity of obesity. Therefore, dietary intervention could be important strategy for the prevention of metabolic syndrome and associated diseases.Obesity arises from a sustained positive energy balance which triggers a pro-inflammatory response. These disturbances culminate in impaired insulin signaling, dysregulated glucose homeostasis and consequent development of insulin resistance. Chronic inflammation and insulin resistance are now recognized as contributing factors to many modern diseases such as insulin non dependent diabetes mellitus, cardiovascular diseases, Alzheimer disease and cancer. To achieve project objectives we will investigate several interactions that take place in metabolic syndrome pathogenesis: A) Influence of dietary n6/n3 ratio and DHA as a preventive mechanism on the severity of metabolic syndrome, B) Influence of dietary n6/n3 ratio and DHA on therapy of induced metabolic syndrome, C) Parental transmission of predisposition to obesity-related disorders to their offspring and influence of offspring diet on severity of metabolic disorders before and after sexual maturity, D) Interaction between age and metabolic syndrome and E) Cancer lipid metabolism and cancer markers of lipid origin as well as possible link between obesity, metabolic syndrome, low grade chronic inflammation and cancer.Finally, data from the whole project will result in the integration of gained knowledge from all experiments and in better understanding of complex pathogenesis of metabolic syndrome. Integrative approach will allow us to suggest new approaches to dietary prevention and therapy of metabolic syndrome and to better understand underlying link between obesity related chronic inflammation and cancer.]]></summary_en></project><project>
<id>9507</id><title_hr><![CDATA[Aktivno sudjelovanje skupine kućanstava u energetskim tržištima]]></title_hr><title_en><![CDATA[]]></title_en><user_id>7162</user_id><user_firstLast_name>Hrvoje Pandžić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-3911</code><acronim><![CDATA[ANIMATION]]></acronim><duration>01.10.2020 - 30.09.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>856080</team_members_id><team_members_names><![CDATA[ Doktorand: Nikolina Čović ]]></team_members_names><keywords_hr><![CDATA[aktivni potrošači, energetska tržišta, napredna kućanstva, optimizacija, razvoj softvera, laboratorijsko testiranje]]></keywords_hr><keywords_en><![CDATA[active consumers, energy markets, smart homes, optimization, software development, laboratory testing]]></keywords_en><summary_hr><![CDATA[Odziv potrošnje odnosi se na sposobnost potrošača električne energije da mijenja svoju krivulju potrošnje u cilju pružanja fleksibilnosti operatoru sustava, energetskom tržištu ili drugim korisnicima sustava. Velika većina današnjih pružatelja odziva potrošnje pripada skupini industrijskih ili komercijalnih pružatelja odziva potrošnje, dok su kućanstva rijetko uključena u programe odziva potrošnje. Predloženi istraživački projekt planira probuditi tržište odziva potrošnje u kućanstvima te aktivirati njihovu fleksibilnost. Predloženo istraživanje premostit će jaz između vladinih ciljeva, modela znanstvene zajednice i komercijalnih proizvođača sustava oblikovanjem i testiranjem kompletnog kućanstva koje će istovremeno moći na agregirani način sudjelovati na svim energetskim tržištima. Model kućanstva i agregatora bit će isporučen kao novi softverski alat osmišljen kako bi olakšao uključivanje i razumijevanje usluge odziva potrošnje te pokazao profitabilnost i učinkovitost predloženog koncepta.Osnovna ideja projekta je izraditi matematičke modele i opremiti laboratorij stvarnim kućanskim pametnim uređajima, punionicom za električna vozila, stacionarnom baterijom i fotonaponskim sustavom. Ispitat će se mogućnosti nuđenja usluga odziva potrošnje ovakvih kućanstava i definirati optimalna strategija za njihovo grupno sudjelovanje na tržištima. Ishodi istraživanja potaknut će kućanstva da pristupe različitim tržištima i da se transformiraju u aktivne potrošače svjesne svoje potrošnje i svojih računa. Kućanstva ujedinjena u zajedničkom cilju smanjenja troškova bi priključila svoje uređaje na aplikaciju za aktivna susjedstva koja bi ih uskladila i nudila njihove agregirane ponude na tržištu.]]></summary_hr><summary_en><![CDATA[Demand response (DR) refers to the ability of electrical load to change its consumption pattern in order to provide flexibility to the power system operator, in electricity market or to other power system users. Almost all of the demand response provided today is either industrial or commercial, as residential sector is much more delicate and complex to design due to a huge number of distributed resources as well as impact on people’s everyday lives. This especially applies to simultaneous participation of households in various markets. The proposed research project plans to shake up the household DR market and activate the households. The proposed research will bridge the gap between the government goals, scientific community models, and commercial system manufacturers as it will design and test a complete household able to simultaneously participate in an aggregated manner in all markets. The household and the aggregation models will be delivered as new software tools designed to ease the residents’ involvement and understanding of DR and to demonstrate the profitability and effectiveness of the proposed concept.General idea of the proposed project is to mathematically model and physically design a real household equipped with smart and connected devices, rooftop solar panels, EV charging station and a stationary battery. We will test the technical possibilities for DR provision of such households and define optimal market participation strategy for a group of households. Research outputs are aiming to empower and encourage active households to approach different power markets and to transform into active households aware of their power consumption and power bills. The households united under the same goal of cost minimization should connect their appliances to active neighborhood application, which will consolidate them, and submit aggregated bids to different markets. ]]></summary_en></project><project>
<id>9508</id><title_hr><![CDATA[Application of Nanobiotechnology for Nutritional Supplementation with Selenium]]></title_hr><title_en><![CDATA[]]></title_en><user_id>7747</user_id><user_firstLast_name>Zdenko Lončarić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-1288</code><acronim><![CDATA[NutriNTENSe]]></acronim><duration>03.11.2020 - 11.10.2026</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Fakultet agrobiotehničkih znanosti Osijek]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Agrobiotechnical Sciences in Osijek]]></institution_en><team_members_id>858396</team_members_id><team_members_names><![CDATA[ Doktorand: Lucija Galić ]]></team_members_names><keywords_hr><![CDATA[selen, biofortifikacija, nanobiotehnologija, povrće, suplementacija hrane, prehrambeni otpad]]></keywords_hr><keywords_en><![CDATA[selenium, biofortification, nanobiotechnology, vegetables, nutritional supplementation, food waste]]></keywords_en><summary_hr><![CDATA[Selen (Se) je bitan mikroelement koji igra važnu ulogu u metabolizmu i mnogim drugim vitalnim funkcijama. Zbog svoje zaštitne aktivnosti tijekom imunološkog odgovora te kod karcinoma, Se se koristi kao dodatak prehrani. Budući da su biljke glavni izvor Se za ljude i životinje, različite strategije poput biofortifikacije i korištenja biljnih ekstrakata se koriste za razvoj prehrambenih dodataka na bazi Se. Biološka raspoloživost selena varira ovisno o nekoliko čimbenika, uključujući kemijski oblik Se, druge hranjive komponente u hrani, fiziološki status i status Se u organizmu. Glavne zapreke u postizanju optimalnog unosa Se su visoko varijabilni sadržaj u različitim vrstama hrane i uska sigurnosna granica unosa različitih Se oblika. Nanotehnologija omogućuje primjenu selenovih nanočestica (SeNPs), koje posjeduju jaču antioksidativnu aktivnost i nižu toksičnost u odnosu na druge oblike Se. NutriNTENSe projekt ima za cilj istražiti djelotvornost i sigurnost inovativnih nutraceutika i funkcionalne hrane na bazi SeNPs primjenom nanobiotehnoloških metoda. To će se postići razvojem dviju inovativnih klasa Se-nutraceutika: funkcionalnog biofortificiranog povrća sa SeNPs (FBVegs) i Se-nanoceutika (SeNCes) korištenjem ekstrakata prehrambenog otpada za biogenu sintezu SeNPs. Oba tipa Se-nutraceutika bit će podvrgnuta in vitro i/ili in vivo ispitivanjima kako bi se istražila njihova biokompatibilnost, sigurnost, farmakokinetička svojstva i farmakološka aktivnost u usporedbi sa selenatom i/ili kemijski sintetiziranim SeNPs. Osim toga, procijeniti će se moguće sinergističko djelovanje biogenih SeNPs i specifičnih bioaktivnih spojeva iz NutriNTENSe biljaka ili ekstrakata. Rezultati dobiveni NutriNTENse projektom biti će od velike koristi za potrošače, poljoprivredne proizvođače i prehrambenu industriju kao krajnje korisnike ishoda projekta. Treba istaknuti da NutriNTENse ima zeleni karakter s ciljem povećanja primjene zdravih i ekološki prihvatljivih proizvoda.]]></summary_hr><summary_en><![CDATA[Selenium (Se) is an essential trace element playing important role in metabolism and many other vital functions. Due to its protective activity in immune response and cancer, it is widely used as a diet supplement. As plants are the main dietary source of Se for humans and animals, different strategies such as biofortification and plant-based extracts are used to develop Se dietary supplements. Selenium bioavailability varies depending on several factors including chemical form of Se, other dietary components, physiological status and selenium status of the organism. The major obstacles in achieving optimal Se intake are highly variable Se content in different food types and narrow safety margin of supplemental Se forms. Nanotechnology enables application of selenium nanoparticles (SeNPs), due to their enhanced antioxidant activities and lower toxicity as compared to other Se forms. NutriNTENSe project aims to investigate the efficacy and safety of innovative SeNPs-based nutraceuticals and functional food using nanobiotechnological tools. This will be achived by following development of two innovative classes of Se-nutraceuticals: functional SeNPs biofortified vegetables (FBVegs) and Se-nanoceuticals (SeNCes) using food waste extracts for biogenic synthesis of SeNPs. Both types of Se-nutraceuticals will be subjected to in vitro and/or in vivo testings to investigate their biocompatibility, safety, pharmacokinetic properties and pharmacological activity compared to selenite and chemically synthesized SeNPs. In addition, possible synergistic action of biogenic SeNPs and specific bioactive compounds found in NutriNTENSe plants and extracts will be evaluated. Results obtained within NutriNTENse will be of great interest for consumers, agricultural producers and food industry as final beneficiaries of project outcomes. It should be highlighted that NutriNTENse is green project aimed to increase implementation of healthy and environment friendly products.]]></summary_en></project><project>
<id>9512</id><title_hr><![CDATA[Stručno usavršavanje učitelja u funkciji unapređenja rezultata učenja učenika osnovne škole u prirodoslovnom i matematičkom području]]></title_hr><title_en><![CDATA[]]></title_en><user_id>23398</user_id><user_firstLast_name>Branko Bognar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-5256</code><acronim><![CDATA[SURFPRIMA]]></acronim><duration>09.11.2020 - 08.05.2023</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Pedagogija, </scie_field_hr><scie_field_en>Pedagogy, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>861736</team_members_id><team_members_names><![CDATA[ Doktorand: Mia Filipov ]]></team_members_names><keywords_hr><![CDATA[akcijsko istraživanje, eksperimentalno istraživanje, nastava biologije, nastava matematike, stručno usavršavanje učitelja, video tehnologija]]></keywords_hr><keywords_en><![CDATA[action research, biology teaching, experimental research, mathematics teaching, teacher professional development, video technology]]></keywords_en><summary_hr><![CDATA[U većini obrazovnih sustava ne postoji značajna povezanost između stručnog usavršavanja učitelja i rezultata njihovih učenika. Unatoč tome, ne bi bilo dobro zaključiti kako stručno usavršavanje općenito ne doprinosi promjenama u nastavi, već samo da postojeće stručno usavršavanje nije dovoljno učinkovito te da bi ga trebalo mijenjati. Učinkovito stručno usavršavanje je kontinuirano, integrirano s područjem primjene, aktivno i dobro vođeno. Ono uključuje učenje po modelu te refleksivne zajednice prakse za što se mogu koristiti mrežne aplikacije i video zapisi nastave. Svrha ovog projekta je razvoj i provjera učinkovitosti modela stručnog usavršavanja učitelja biologije i matematike koji može doprinijeti kvaliteti učenja učitelja, bitnim promjenama u nastavi i rezultatima koje postižu učenici. Projekt će biti ostvaren kroz četiri faze od kojih će svaka trajati godinu dana. Prva faza namijenjena je ispitivanju stanja u svezi stručnog usavršavanja i pripremi akcijskog i eksperimentalnog istraživanja koje će biti ostvareno tijekom druge, odnosno treće faze istraživanja. U završnoj fazi na temelju analize rezultata prethodno provedenih istraživanja razradit ćemo model stručnog usavršavanja primjenjiv u hrvatskom obrazovnom kontekstu koji ćemo prezentirati stručnoj i znanstvenoj javnosti.S obzirom da u Hrvatskoj ne postoje istraživanja stručnog usavršavanja u kojima su praćene promjene u nastavi i rezultati učenja učenika, radovi koje namjeravamo publicirati mogu doprinijeti spoznajama u svezi mogućnosti stvaranja učinkovitog stručnog usavršavanja, a time i boljim rezultatima naših učenika. ]]></summary_hr><summary_en><![CDATA[In most education systems, there is no significant association between the teacher&#39;s professional development and the results of their students. Nevertheless, it would not be good to conclude that the professional development in general does not contribute to changes in teaching, but only that existing professional development is not efficient enough and that it should be changed. Effective professional development should be directed to a specific teaching area. It should offer active and collaborative learning for teachers starting from the best practice models. It should be well-managed. Teachers need timely feedback and reflection. In order to make reflections, video presentations are increasingly used. Finally, to make changes in the teaching process, continuity and time are needed. The purpose of this project is to develop and verify the effectiveness of a model of professional development appropriate to the Croatian educational context that can contribute to the quality of teacher&#39;s learning, substantial changes in teaching and the achievements of students in biology and mathematics. The project will be realized through four phases, each of which will last for one year. The first phase is aimed at examining the state of the professional development and the preparation of action and experimental research that will be realized during the second and the third phase of the project. In the final phase, based on the analysis of the results of the previous research, we will devise a model of professional development applicable in the Croatian education system. Since there are no research studies on professional development in Croatia exploring changes in teaching and student&#39;s learning outcomes, the accounts we intend to publish can contribute to the knowledge about the possibilities of creating effective professional development, especially for teachers in science and mathematics where our students are less successful.]]></summary_en></project><project>
<id>9515</id><title_hr><![CDATA[Jadranska maritimna hodočašća u lokalnom, nacionalnom i transnacionalnom kontekstu ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>22625</user_id><user_firstLast_name>Mario  Katić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-7544</code><acronim><![CDATA[PILGRIMAR]]></acronim><duration>16.12.2020 - 15.12.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Etnologija i antropologija, </scie_field_hr><scie_field_en>Ethnology and anthropology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zadru]]></institution_hr><institution_en><![CDATA[University of Zadar]]></institution_en><team_members_id>861526</team_members_id><team_members_names><![CDATA[ Doktorand: Petra Valovičić ]]></team_members_names><keywords_hr><![CDATA[hodočašće, Jadran, maritimni način života, turizam, baština, identitet, utjelovljeno iskustvo ]]></keywords_hr><keywords_en><![CDATA[pilgrimage, Adriatic, maritime way of life, tourism, heritage, identity, embodied experience]]></keywords_en><summary_hr><![CDATA[Uzimajući odabrana marijanska svetišta jadranskoga prostora kao arhetipska, maritimna hodočašća definiramo kao godišnje rituale štovanja lokalnih svetaca koja uključuju translokaciju svetoga objekta, ljudi, ili i jednoga i drugoga preko mora kao dio ritualne strukture. Naša je pretpostavka da su maritimna hodočašća postala „sidra“ za lokalne zajednice zbližavajući izmještene članove zajednice i održavajući transnacionalne veze. Štoviše, s razvojem turizma, maritimna hodočašća se ponovno „stvaraju“ te postaju važan ili glavni pokretač lokalne turističke ponude. Naša je hipoteza da su ovi različiti interesi oblikovani i potaknuti globalizacijskim procesima i da su lokalne hodočasničke prakse usmjerene više prema sekularnim manifestacijama koje rezultiraju procesom stvaranje baštine. Jedna od ideja ovoga interdisciplinarnog projekta je skupiti lokalno znanje pomoću etnografije kao osnovne metodologije, interpretirati mjesta unutar njihova povijesnoga konteksta nastanka pomoću novih spoznaja na temelju arhivskoga rada, kontekstualizirati ih pomoću GIS metodologije promatrajući ove religijske i kulturne prakse unutar njihova, vrlo važnoga, geografskoga konteksta morskoga krajolika i otoka. Te provesti analizu utjecaja turizma koja će se temeljiti na anketnom ispitivanju te organiziranju fokus grupa. Na temelju svega navedenoga, istraživačka skupina će proizvesti studiju koja će pokazati smjer održivoga razvoja maritimnih hodočašća na odabranim lokacijama kako bi lokalne zajednice imale koristi od maritimnih hodočašća kao resursa u održavanju zajednice, a s druge strane, zadržale utjecaj turizma u realnim okvirima i spriječile trajno devastiranje ovih mjesta i praksi. Cilj je i omogućiti bolje razumijevanje oblikovanja i prihvaćanja religijskih praksi unutar specifičnoga povijesnoga i geografskoga konteksta. Te na kraju, definirati temeljne karakteristike maritimnih hodočašća i uspostaviti referentnu točku za buduća istraživanja maritimnih hodočašća.  ]]></summary_hr><summary_en><![CDATA[With the Adriatic maritime pilgrimages serving as an archetype, we define maritime pilgrimages as those particular annual rites of veneration that include the translocation of sacred objects, people or both over water (including symbolical enactment) as a part of the ritual structure. Our hypothesis is that maritime pilgrimages have become anchors for local communities bringing together displaced members of the community and sustaining transnational ties. Moreover, with the development of tourism, maritime pilgrimages may have also been reinvented as one more, or in some cases the main, local tourist attraction. This study hypothesizes that these diverse interests may have been encouraged by globalization and that local pilgrimage practices may have evolved toward more secular and popular manifestations directed to “heritagization”. One of the ideas of this project is to gather local knowledge form the native point of view based on ethnographic research, frame it within historical background and new archival sources, contextualize with GIS methodology trying to observe these religious and cultural practices within their, very important, geographical context of the seascape and island, conduct a tourism study that will be produced based on a survey research and the organization of the focus groups. Following that, the project participants will produce a study that should indicate a sustainable development of these locations and practices in order to enable local community to benefit from maritime pilgrimage as a resource for keeping the community alive, but on the other hand, keeping the tourism impact on realistic levels in order not to irretrievable destroy these locations and practices. Provide a better understanding of the formation and adoption of religious practices within very specific historical and geographical context. And, define the main characteristics of maritime pilgrimages and establish a point of reference for future maritime pilgrimage research.]]></summary_en></project><project>
<id>9517</id><title_hr><![CDATA[Novi spojevi temeljeni na bioizosterima purina za ispitivanje njihovih antitumorskih i antipatogenih djelovanja]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3924</user_id><user_firstLast_name>Tatjana Gazivoda Kraljević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-2997</code><acronim><![CDATA[PurBioCaPa]]></acronim><duration>27.10.2020 - 25.04.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet kemijskog inženjerstva i tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Chemical Engineering and Technology]]></institution_en><team_members_id>861758</team_members_id><team_members_names><![CDATA[ Doktorand: ANJA RAKAS ]]></team_members_names><keywords_hr><![CDATA[purinski bioizosteri, benzimidazol, benzotiazol, 1,2,3-triazol, antitumorska, antibakterijska, antitripanosomska aktivnost]]></keywords_hr><keywords_en><![CDATA[purine bioisosteres, benzimidazole, benzothiazole, 1,2,3-triazole, anticancer, antibacterial, antitrypanosomal activity]]></keywords_en><summary_hr><![CDATA[S ciljem razvoja novih kemijskih entiteta sa snažnim i selektivnim antitumorskim, antibakterijskim i antitripanosomskim učinkom, predlažemo dizajniranje i sintezu novih purinomimetika primjenom strategije dizajniranja lijekova, poput bioizosterije i izmjene skeleta kod kojih se atomi dušika u aromatskom prstenu zamjenjuju atomom ugljika ili drugim heteroatomom. Derivati strukturno srodni purinima povezat će se s drugom farmakofornom jedinicom preko različitih premosnica kako bi se odredio njihov utjecaj na interakciju s molekulskom metom, a time i na biološku aktivnost. Radi ispitivanja moguće prednosti održivih sintetskih metoda u odnosu na tradicionalni pristup, uz klasične će se sintetske metode izabranih reakcija provesti i nekonvencionalne, poput mehanokemijskih i protočnih reakcija provedenih u mikroreaktoru. Kako bi se ostvario cilj predloženog projekta, nužno je koordinirano provođenje sinteze i optimiranje struktura, zajedno s metodama dizajniranja spojeva i ispitivanja njihovih bioloških djelovanja. Potom će se provesti antipatogena i citostatska ispitivanja s posebnim naglaskom na dodatna ispitivanja novopripravljenih spojeva na izabrane kemorezistentne tumorske stanične linije i bakterijske kliničke sojeve koji su rezistentni na postojeće antibiotike. Nadalje, za najdjelotvornije spojeve provest će se istraživanja molekulskog mehanizma djelovanja usmjerena na polinukleotide (DNA/RNA), odnosno enzime odabrane analizom in silico. Na temelju rezultata bioloških ispitivanja, ciljanim će se strukturnim modifikacijama optimirati strukture odabranih spojeva kandidata u svrhu poboljšanja njihove biološke aktivnosti i ADMET svojstava. Očekujemo da će u konačnici projekt rezultirati novim predvodnim spojevima sa selektivnim i učinkovitim antipatogenim, odnosno citostatskim djelovanjem, koji neće biti toksični, i koji će zadovoljiti potrebne kriterije za sljedeću fazu optimiranja predvodnog spoja.]]></summary_hr><summary_en><![CDATA[With the aim to develop new chemical entities with marked and selective anticancer, antibacterial and antitrypanosomal activity, we propose the design and synthesis of novel purinomimetics using the bioisosterism and scaffold hop by swapping nitrogen atoms with carbon and other heteroatoms in an aromatic ring. Purine-related derivatives will be linked to another pharmacophoric unit through various linkers to assess their impact on molecular target interaction and thereby biological activity. To evaluate the benefit of sustainable synthetic method to traditional approach, batch-based syntheses of chosen reactions will be translated to non-conventional, such as mechanochemical and micro-flow processes. In order to accomplish the aim of the proposed project, the synthesis and structure optimization along with drug design tools and biological evaluations will be performed in a coordinated manner. Furthermore, antipathogenic and cytostatic evaluations of newly prepared compounds will be performed emphasizing the additional assays on selected chemoresistant cancer cell line and antibiotic-resistant bacteria clinical strains. The molecular mechanism studies of the most effective compounds targeting polynucleotides (DNA/RNA) or enzymes, indicated by in silico analysis, will be subsequently carried out. On the basis of results of biological evaluations, structure optimization by chemical modification of selected compound candidates will be performed to improve their biological potency and ADMET properties. Finally, we expect that new lead compounds with selective and pronounced antipathogenic and/or cytostatic activities with no toxicity will be identified and satisfy necessary criteria for further lead optimization phase. ]]></summary_en></project><project>
<id>9518</id><title_hr><![CDATA[Molekularna epidemiologija, kliničke osobitosti i skrb za osobe zaražene HIV-om u Hrvatskoj]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1084</user_id><user_firstLast_name>Josip Begovac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-5963</code><acronim><![CDATA[MEKOSH/MECCHC]]></acronim><duration>01.11.2020 - 04.11.2025</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Clinical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>26031</team_members_id><team_members_names><![CDATA[ Doktorand: Ivana Benković ]]></team_members_names><keywords_hr><![CDATA[HIV, podtipovi, rezistencija, sekvencioniranje, ateroskleroza, sifilis, događaji, mHealth]]></keywords_hr><keywords_en><![CDATA[HIV, subtypes, resistance, sequencing, atherosclerosis, syphilis, events, mHealth]]></keywords_en><summary_hr><![CDATA[Usprkos uspješnom liječenje zaraza HIV-om je i nadalje važan javnozdravstveni problem. Molekularna epidemiologija se mijenja u smislu sve veće pojave klastera infekcija, rezistencija na nove lijekove, osobito inhibitora integraze se sve češće otkriva. Popratne bolesti poput glavnih kliničkih događaja (npr. infarkt miokarda, maligne bolesti, dijabetes, kronična bubrežna bolest, dekompenzacije jetre) se sve češće opažaju, a neke poput periferne ateroskleroze su nedovoljno ispitane. Epidemiologija sifilisa se proteklih godina značajno promijenila. Pristup skrbi se danas također mijenja jer postoje brojni novi uređaji i nove metode komunikacije. Mnoge ot tih novih komunikacija mHealth nisu dovoljno ispitane u odnosu na kvalitetu i dostupnost zdravstvene skrbi. Radi se o istraživanju koje ima više ciljeva: 1) Istraživanje molekularne epidemiologije HIV-1 infekcije (cilj A), 2) istraživanja prevalencije primarne rezistencije HIV-a na antiretrovirusne lijekove (cilj B), 3) Ispitati prevalenciju i incidenciju glavnih kliničkih događaja u osoba zaraženih HIV-om u Hrvatskoj te utvrditi čimbenike povezane s tim događajima, u razdoblju od 2019. do 2022. g. (cilj C) 4) Istražiti utjecaj HIV infekcije na perifernu ateroskleroze (cilj D), 5) odrediti incidenciju i prevalenciju sifilisa te učinkovitost liječenja u osoba zaraženih HIV-om u Hrvatskoj (cilj E) te 6) ispitati kako aplikacija mHealth „EmERGE“ utječe na skrb osoba zaraženih HIV-om (cilj F). Krajnji cilj je da rezultati ovog istraživanja doprinesu unaprjeđivanju skrbi oboljelih od HIV-infekcije, a da se putem molekularne epidemiologe uspješnije provodi prevencija HIV-infekcije.]]></summary_hr><summary_en><![CDATA[Despite the success of HIV therapy, HIV infection is still an important public health issue. Molecular epidemiology is changing in the sense that clusters do significantly contribute to new infections, resistance to new drugs, especially the integrator inhibitors, is also increasingly detected. Comorbidities such as major clinical events (eg myocardial infarction, malignant diseases, diabetes, chronic kidney disease, liver decompensation) are more commonly observed, and some such as peripheral atherosclerosis are underestimated. The epidemiology of syphilis has changed significantly in recent years. Access to care today is also changing because there are many new devices and new communication methods. Many of these new mHealth communications have not been sufficiently tested against the quality and impact on the health care system. Our project has multiple goals: 1) Investigating the molecular epidemiology of HIV-1 infection (goal A), 2) the prevalence of primary HIV resistance to antiretroviral drugs (goal B), 3) to examine the prevalence and incidence of major clinical events in (goal C) 4) to investigate the impact of HIV infection on peripheral atherosclerosis (goal D), 5) to determine the incidence and prevalence of syphilis in HIV infected people in Croatia and to determine the factors associated with them in the period 2019-2022 and to assess the effectiveness of treatment of syphilis in people infected with HIV in Croatia (goal E) and 6) to examine how the mHealth &#39;&#39;EmERGE&#39;&#39; application affects the care of people infected with HIV (goal F). The ultimate goal is that the results of this research contribute to improving the care of HIV-infected people, and that through the molecular epidemiologic investigation HIV infection prevention becomes more successful.]]></summary_en></project><project>
<id>9519</id><title_hr><![CDATA[Određivanje fizikalno-kemijskih svojstava i toksičnosti nanočestica srebra, bakra i plastike kao potencijalno štetnih novih materijala u obalnim vodama]]></title_hr><title_en><![CDATA[]]></title_en><user_id>12729</user_id><user_firstLast_name>Petra Peharec Štefanić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-5767</code><acronim><![CDATA[NANO-EMC2]]></acronim><duration>28.10.2020 - 27.10.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>858380</team_members_id><team_members_names><![CDATA[ Doktorand: Bruno Komazec ]]></team_members_names><keywords_hr><![CDATA[istraživanja mora i ušće rijeke, nanočestica, nanoplastika, kinetika, toksičnost, bioakumulacija, klimatske promjene ]]></keywords_hr><keywords_en><![CDATA[marine and estuarine research, nanoparticle, nanoplastic, kinetics, toxicity, bioaccumulation, climate change]]></keywords_en><summary_hr><![CDATA[Usporedno s rastućom uporabom proizvoda koji sadrže nanočestice, očekuje se značajno povećanje njihovog oslobađanja u okolinu. Mnoga istraživanja vezana za ponašanje i sudbinu umjetno proizvedenih nanočestica (engl. engineered nanoparticles, ENPs) usmjerena su na kopnene vodene sustave (jezera, rijeke i podzemne vode) zbog očekivanja da će se nanočestice oslobođene u okolinu s vremenom razgraditi u tim istim sustavima bez značajnog prijenosa na ostale dijelove okoliša. Međutim, uzimajući u obzir mnoga nastanjena mjesta u obalnim područjima, potencijalno opterećenje velikom količinom nanočestica u ušćima rijeka kao i priobalnim vodama u nadolazećim godinama sve je značajnije. Budući da postoje dokazi da različite nanočestice mogu biti toksične za brojne organizme, posebno osjetljivi bi mogli biti organizmi u ušćima rijeka i u priobalnim područjima. Međutim, dostupne informacije vezane za ponašanje nanočestica u elektrolitima velike ionske jakosti, posebice učinak koji mogu imati njihovi omotači na koloidnu stabilnost, specijaciju i kinetiku, malobrojne su i nedorečene. Nadalje, trenutno postoji veoma malo raspoloživih podataka o međusobnom djelovanju nanočestica s širokim rasponom raznih organizama u bočatoj i obalnoj vodi. Ovaj će projekt istražiti fizikalno-kemijsko ponašanje nanočestica srebra, bakra i polimera/plastike različitih veličina i površinskih omotača, kao potencijalno opasnih materijala u vodenom stupcu bočatih i obalnih voda, uzevši u obzir abiotičke čimbenike kao što su salinitet, pH, koncentracija kisika i otopljena organsku tvar. Standardizirani biokemijski testovi, prilagođeni specifičnim svojstvima i učinku interferencije ENP, koristiti će se za mjerenje širokog raspona indikatora toksičnosti na izabrane organizme od algi i makroalgi do ježinaca, školjkaša i rakova. Ovim projektom omogućit će se po prvi puta cjelokupni pregled ponašanja nanočestica srebra, bakra i plastike u bočatoj vodi kao kompleksnoj zoni prijelaza iz slatkovodne u morsku vodu.]]></summary_hr><summary_en><![CDATA[In parallel with the growing use of nanoparticle-containing products, their release into the environment over the coming years is expected to increase significantly. Much of the research on the behaviour and fate of engineered nanoparticles (ENPs) in the environment has focused on terrestrial aquatic systems (lakes, rivers and groundwater) due to the expectation that ENPs would eventually be degraded in these systems without significant transport to other environmental compartments. However, with many large population centres located in near-coastal areas, the potential environmental load of nanoparticles in estuarine and coastal waters over the coming years is enormous. As there is increasing evidence that various nanoparticles may be toxic to a range of organisms, biota in estuarine and coastal waters may thus be particularly vulnerable. However, available data on how nanoparticles behave in high strength electrolytes, in particular the effect of their coating on colloidal stability, speciation or ion release kinetics are scarce. Further, there is little data on how such aged nanoparticles interact with the wide range of diverse organisms in brackish and coastal waters.This project will investigate the physico-chemical behaviour of silver, copper and polymer/plastic nanoparticles with a range of different sizes and surface coatings, as materials of concern, in brackish and marine waters based on a range of abiotic factors including salinity, pH, oxygen concentration and dissolved organic matter. Standardised biochemical tests, adapted to take into account the specific properties and interference effects of ENPs, will be used to measure a range of toxicity endpoints in selected organisms ranging from algae and macroalgae to urchins, mussels and crabs. The results from this project will provide for the first time a systematic overview of the behaviour of silver, copper and plastic nanoparticles in brackish water as a complex transition zone from fresh to salt water.]]></summary_en></project><project>
<id>9523</id><title_hr><![CDATA[Razvoj i naslijeđe viteških redova u Hrvatskoj]]></title_hr><title_en><![CDATA[]]></title_en><user_id>25921</user_id><user_firstLast_name>Juraj Belaj</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-9305</code><acronim><![CDATA[milOrd]]></acronim><duration>01.09.2020 - 29.04.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Arheologija, </scie_field_hr><scie_field_en>Archeology, </scie_field_en><institution_hr><![CDATA[Institut za arheologiju]]></institution_hr><institution_en><![CDATA[Institute of Archaeology in Zagreb]]></institution_en><team_members_id>26610</team_members_id><team_members_names><![CDATA[ Doktorand: Sebastijan Stingl ]]></team_members_names><keywords_hr><![CDATA[Viteški redovi, templari, ivanovci, baština, sakralna arhitektura, fortifikacijska arhitektura, grobni nalazi, antropološke analize	]]></keywords_hr><keywords_en><![CDATA[Military orders, Templars, Hospitallers, heritage, sacral architecture, fortification architecture, grave finds, anthropological analysis]]></keywords_en><summary_hr><![CDATA[Predloženim se projektom namjerava interdisciplinarno istražiti templare i ivanovce u Hrvatskoj, prateći njihov razvoj i mijene njihovih lokaliteta. Proučavat će se transformacije različitih pokretnih i nepokretnih nalaza i uzoraka na sljedećim lokalitetima: Gora, Ivanec, Sv. Martin na Prozorju, Gradišče kod Margečana, Pakrac, Račeša i Vrana. U obzor istraživanja ući će i ostali sačuvani objekti viteških redova te muzeji i arhivi. Ciljevi se namjeravaju postići usporednim istraživanjima i analizama na više razina: povijesnih i povijesno-umjetničkih izvora, arheoloških nalaza, uzoraka tla i ljudskih kosturnih ostataka. Odabrani uzorci bit će podvrgnuti radiokarbonskoj analizi te analizi stabilnih izotopa dušika i ugljika. Temeljna pitanja na koja će se komparativnom metodom tražiti odgovori su: mogu li se na temelju povijesnih, arheoloških, biološko-antropoloških i arheobotaničkih podataka, kao i na ostacima graditeljske i umjetničke građe, ustanoviti inovacije za koje se pretpostavlja da su ih viteški redovi donijeli u promatrane krajeve te kako su time utjecali na kvalitetu života svojih podložnika? Tijekom predloženog projekta planira se zapošljavanje doktoranda/ice čija će tema biti usko povezana s temom projekta. Diseminacija znanja planirana je tijekom čitavog trajanja predloženog projekta putem javnih predavanja, izlaganja na kongresima, objavljivanja radova u znanstvenim časopisima, organiziranja međunarodne konferencije, postavljanja izložbe te objavljivanja e-monografije s rezultatima projekta. Informacije o poduzetim aktivnostima bit će kontinuirano objavljivane na mrežnim stranicama projekta. Predloženim projektom produbit će se dosadašnje spoznaje te steći nove o slabo istraženim viteškim redovima na ovome prostoru: povećat će se uvid u količinu i kvalitativne značajke njihovih materijalnih tragova, u njihov utjecaj na lokalne zajednice i lokalnu kulturu, u mijene viteških redova i njihovih lokaliteta te će se jasnije moći definirati njihova ostavština.]]></summary_hr><summary_en><![CDATA[The goal of the proposed project is to conduct an interdisciplinary research of the military orders in Croatia by observing their development and changes on their sites. Transformations of various finds and samples will be studied on the following sites: Gora, Ivanec, St Martin-Prozorje, Gradišče-Margečan, Pakrac, Račeša and Vrana. Other preserved structures of the military orders will also be included in the research as well as museums and archives. The plan is to reach the goals by parallel research and analyses on several levels: of archaeological, historical and art historical sources, samples of soil and human skeletal remains. Selected samples will be subjected to radiocarbon analysis and stable carbon and nitrogen isotope analysis. We will try to answer the following question by means of comparative method: Can the innovations which are presumed to be brought to the observed areas by the military orders and their influence on the life of their subjects be identified based on historical, archaeological, biological anthropological and archaeobotanical data and the remains of architecture and artwork? In the course of the proposed project, employment of a doctoral student is planned, whose theme will be closely related to the theme of the project. Dissemination of knowledge is planned via public lectures, presentations at conferences, papers in scientific journals, organising an international conference, mounting an exhibition and publishing an e-monograph with project results. Information on the conducted activities will be continuously posted on the website. The proposed project will deepen the existing and provide new insights on the scarcely researched military orders in this area: it will expand our knowledge about the quantity and qualitative features of their material remains, their influence on local communities and local culture and about the transformations of military orders and their sites, thereby enabling us to define their heritage more clearly.]]></summary_en></project><project>
<id>9525</id><title_hr><![CDATA[Urbane budućnosti: zamišljanje i aktiviranje mogućnosti u nemirnim vremenima]]></title_hr><title_en><![CDATA[Urban Futures: Imagining and Activating Possibilities in Unsettled Times]]></title_en><user_id>311</user_id><user_firstLast_name>Valentina Gulin Zrnić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IPS</proposal_type><proposal_call>2020-01</proposal_call><code>IPS-2020-01-7010</code><acronim><![CDATA[FUTURES]]></acronim><duration>01.11.2020 - 15.02.2024</duration><status>Završio</status><financ_value>64.722,94 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Etnologija i antropologija, </scie_field_hr><scie_field_en>Ethnology and anthropology, </scie_field_en><institution_hr><![CDATA[Institut za etnologiju i folkloristiku]]></institution_hr><institution_en><![CDATA[Institute of Ethnology and Folklore Research in Zagreb]]></institution_en><team_members_id>1045, 12608, 4789, 4785, 865089, </team_members_id><team_members_names><![CDATA[Jasna Čapo, Marina Blagaić Bergman, Tihana Rubić, Nevena Škrbić Alempijević, Mirna Tkalčić Simetić, ]]></team_members_names><keywords_hr><![CDATA[gradovi, budućnosti, vizije, javni prostori, kreativnost, građanska participacija]]></keywords_hr><keywords_en><![CDATA[cities, futures, visions, public spaces, creativity, civil participation]]></keywords_en><summary_hr><![CDATA[Ovaj urbani etnološki/kulturnoantropološki projekt posvećen je istraživanju stvaranja budućnosti u izabranim hrvatskim i slovenskim gradovima. Stvaranje budućnosti sintagma je koja se odnosi na sveobuhvatno razumijevanje elemenata koji se povezuju u zamišljanju, anticipiranju i percipiranju budućnosti – kognitivno, diskurzivno i afektivno – kao i u modalitetima svakodnevnog života i angažmana koji iskazuju određeni odnos prema budućnosti. Procesi urbanog stvaranja budućnosti bit će analizirani iz perspektive “odozgo” (strateški gradski dokumenti i vizije), “odozdo” (građanske udruge i inicijative) te iz individualnih/osobnih perspektiva (iskustva, očekivanja, prakse), posebice mladih. “Budućnost” kao novi(ji) predmet istraživanja u etnologiju i kulturnoj antropologiji definira se kao kulturno i kontekstualno relativan, te se tako, zajedno s vizurama vjerojatnosti i mogućnosti koje su imanentne poimanju budućnosti, postavlja široki okvir za istraživanje mnogostrukih urbanih budućnosti – željenih i neželjenih, službenih i alternativnih, podržanih ili onih kojima se odupire, prijepornih, izazovnih, nevidljivih, “utišanih” ili “ukradenih”. Projekt je čvrsto utemeljen u etnografskom istraživanju i diskurzivnoj analizi, a strukturiran je kroz tri istraživačke okosnice: javni prostori (budući prostorno-društveni gradski projekti i njihov potencijal da unaprijede društvenu integraciju, inkluziju, zdravlje i dobrobit građana), kreativnost i inovativnost (kreativna čvorišta koja razvijaju različiti akteri u cilju izgradnje i promocije dobrih praksi, edukacije i društvene angažiranosti) te građanska participacija (različiti načini na koje građani aktiviraju “pravo na grad” i doprinose aktualnim raspravama o djelotvornom gradskom upravljanju kao preduvjetu za prihvatljive i održive urbane budućnosti). Ovim se internacionalnim projektom želi također uspostaviti šira mreža za komparativna etnološka/kulturnoantropološka istraživanja (urbanih) budućnosti. ]]></summary_hr><summary_en><![CDATA[This urban ethnological/cultural anthropological project is dedicated to in-depth research of future-making in selected Croatian and Slovenian cities. Future-making refers to comprehensive understanding of elements which are combined in imagining, anticipating and perceiving futures – cognitively, discursively, and affectively – as well as in modalities of everyday life and engagement that contain a particular relationship towards futures. The process of urban future-making will be analyzed from top-down (strategic documents and visions of particular cities) and bottom-up (civil associations and initiatives) perspectives, as well as from individual/personal perspectives (experiences, expectations, practices), particularly of young people. “Future” as a (novel) object of study in ethnological/cultural anthropological terms is considered culturally and contextually dependent, and together with the notions of probabilities and possibilities which are immanent to future, it sets the stage for researching multiple urban futures – desired and undesired, official and alternative, supported and resisted, contested, challenged, as well as invisible, “silenced”, or “stolen”. The project is firmly grounded in ethnography and discourse analysis and is structured around three axes of research: public space (future-oriented spatial-social urban projects and their potential to enhance social integration, inclusion, health, and wellbeing for urban citizens); creativity and innovations (creative hubs developed by various actors to build and promote good practices, education, and social engagement envisioning futures); and civic participation (diverse ways in which citizens enact “the right to the city”, contributing to current debates on effective urban governance as a prerequisite of liveable and sustainable urban futures). This cross-national project seeks to establish a wider network for comparative ethnological/cultural anthropological (urban) futures research.]]></summary_en></project><project>
<id>9526</id><title_hr><![CDATA[Transormacija robota u edukacijsko sredstvo]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6592</user_id><user_firstLast_name>Ana Sović Kržić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-7166</code><acronim><![CDATA[TRES]]></acronim><duration>01.10.2020 - 01.10.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>857307</team_members_id><team_members_names><![CDATA[ Doktorand: Ivan Kunović ]]></team_members_names><keywords_hr><![CDATA[edukacijski robot, analitika učenja, obrada video signala, otkrivanje znanja u skupovima podataka, edukacijsko sredstvo, nastavni materijali]]></keywords_hr><keywords_en><![CDATA[educational robot, learning analytics, video processing, data mining, educational tool, learning materials]]></keywords_en><summary_hr><![CDATA[Današnji trend je korištenje velikog broja elektroničkih uređaja u razredu: pametne ploče, prezentacije, Internet, edukacijski roboti. Iz mnoštva uređaja i informacija, teško je odrediti pomažu li oni uopće u poučavanju. Mnoge aktivnosti se upravo svode na njihovo korištenje, a ne na iskorištavanje njihovih prednosti s ciljem poučavanja. Predloženi projekt će razviti metodologiju evaluacije korištenja edukacijskih robota u poučavanju osnovnoškolskih predmeta. Pri tome će se uzeti u obzir postignuta razina znanja, ali i zadovoljstvo učenika za vrijeme i nakon održanog sata. Dodatno, roboti će se koristiti za identifikaciju individualne strategije učenja svakog učenika. Na temelju razvijene metodologije i eksperimentalnih rezultata, napravit će se usporedna analiza edukacijskih robota koji postoje na tržištu. Kako bi se postigli ciljevi projekta koristit će se analitički podaci koje je moguće prikupiti iz samih robota i njihovih programskih okruženja za vrijeme njihove upotrebe. Razvit će se algoritmi obrade prikupljenih informacija, njihova analiza, evaluacija i vizualizacija. Predložit će se prototip sustava koji uključuje unaprijeđene edukacijske robote, individualnu strategiju učenja učenika i nastavne materijale, a sa ciljem postizanja maksimuma znanja i uz maksimalno ugodan proces učenja. Istraživači okupljeni u istraživačku grupu su iskusni u dizajniranju, programiranju i korištenju edukacijskih robota, u razvoju metodologije istraživanja, u radi s učenicima osnovnih škola, te u otkrivanju znanja u skupovima podataka i u razvoju metoda znanosti o podacima.]]></summary_hr><summary_en><![CDATA[Today&#39;s trend is to use a number of electronic devices during the class: smart boards, presentations, the Internet, educational robots. From a plenty of devices and information, it is difficult to determine do they help or not in teaching pupils. Many activities are just about how to use the devices, and not to exploit their strengths in the teaching process. Proposed project will develop methodology for evaluation of the usage of educational robots in teaching primary school subjects. The methodology will consider the level of knowledge as well as learners’ satisfaction during and after the lessons. Additionally, the robots will be used for identification of individual learning strategies. Based on the developed methodology and experimental results, comparison of the state-of-the-art educational robots will be made. To achieve the project goals, analytic data will be collected from the logs of the educational robots and their programming environments. Algorithms for processing of the collected data, their analysis, evaluation and visualization will be developed. Finally, a prototype of a system, that includes the improved educational robots, the individual learning strategies and teaching materials will be proposed. The aim of the prototype is to achieve the maximum of the knowledge through a satisfying learning process. Researchers gathered in the research group have experience in designing, programming and using educational robots, in developing research methodologies, in field work with pupils, and in data mining and data science methods.]]></summary_en></project><project>
<id>9527</id><title_hr><![CDATA[Signalni mehanizmi i metaboličke promjene u diferencijaciji stanica akutne mijeloične leukemije]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4677</user_id><user_firstLast_name>Dora Višnjić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-2873</code><acronim><![CDATA[SignalmetabAML]]></acronim><duration>01.11.2020 - 31.10.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>861749</team_members_id><team_members_names><![CDATA[ Doktorand: Tomislav Smoljo ]]></team_members_names><keywords_hr><![CDATA[signaliziranje, AMPK, diferencijacija, ciklus, leukemija]]></keywords_hr><keywords_en><![CDATA[signaling, AMPK, differentiation, cycle, leukemia]]></keywords_en><summary_hr><![CDATA[Akutna mijeloična leukemija (AML) je heterogena skupina bolesti koja je obilježena nekontroliranom proliferacijom blasta koji su zakočeni u ranoj fazi diferencijacije. Najuspješnije farmakološko liječenje AML je diferencijacijsko liječenje pomoću sve-trans-retinske kiseline (ATRA, prema engl. all-trans retinoic acid). Međutim, ATRA se rabi isključivo u liječenju akutne promijelocitne leukemije (APL),  podvrste AML koja sadrži translokaciju t(15;17). Svi ostali oblici AML liječe se intenzivnom kemoterapijom koja nije značajno povećala trajanje remisije ili opće preživljenje. Naše nedavno istraživanje pokazalo je da 5-aminoimidazol-4-karboksamid ribonukleozid (AIKAR, akadezin) potiče apoptozu i pospješuje diferencijaciju staničnih linija AML koje nisu APL, ali je mehanizam djelovanja AIKAR-a još uvijek nepoznat. Stoga je svrha predloženih istraživanja određivanje mehanizama koji su odgovorni za povoljno djelovanje AIKAR-a u stanicama non-APL AML te otkrivanje signalnih mehanizama i metaboličkih promjena koje su odgovorne za monocitnu i granulocitnu diferencijaciju stanica AML. U istraživanju ćemo rabiti komercijalne stanične linije AML da bismo opisali: a) ulogu i mehanizam autofagije u monocitno/makrofagnoj i granulocitnoj diferencijaciji, b) promjene u metabolizmu tijekom diferencijacije i prolaska kroz stanični ciklus, te c) ulogu deacetilaza Sirt u monocitno/makrofagnoj i granulocitnoj diferencijaciji staničnih linija AML. Dodatno, ispitat ćemo učinke AIKAR-a in vitro na uzorcima blasta izoliranih iz oboljelih od AML. Istraživanja signalnih mehanizama odgovornih za diferencirajući učinak u leukemijskim stanicama mogu u konačnici pridonijeti uspješnijem liječenju oboljelih od AML.]]></summary_hr><summary_en><![CDATA[Acute myeloid leukemia (AML) is a heterogeneous group of diseases characterized by clonal proliferation of blasts that are blocked at an early stage of differentiation. The most successful pharmacological therapy of AML is differentiation therapy with all-trans-retinoic acid (ATRA); however, ATRA-based therapy is restricted to acute promyelocytic leukemia (APL), a particular subtype that carries t(15;17) translocation. All other AMLs are treated with intensive chemotherapy, which have not significantly improved the disease-free or overall survival. Our recent study demonstrated that 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR, acadesine) induces apoptosis and enhances differentiation of non-APL AML cell lines, but the mechanism is still unknown. Therefore, proposed studies are aimed to determine the mechanism responsible for beneficial effects of AICAR in non-APL AML cells and to further elucidate signaling mechanisms and metabolic changes responsible for monocytic and granulocytic differentiation of AML cells. We will use commercially available AML cell lines to define: a) the role and the mechanism of autophagy in monocytic/macrophage and granulocytic differentiation, b) the changes in metabolism during differentiation and cell cycle progression, and to determine c) the role of Sirt deacetylase in monocytic/macrophage and granulocytic differentiation of AML cell lines. In addition, in vitro profiling of the sensitivity of primary AML samples to AICAR will be performed. The proposed project aims to define signaling mechanisms responsible for differentiation of leukemia cells, which may eventually lead to the development of an improved therapy, thus contributing to well-being of AML patients.]]></summary_en></project><project>
<id>9535</id><title_hr><![CDATA[Učinkoviti sustavi za obradu signala namijenjeni programski definiranom radiju]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6945</user_id><user_firstLast_name>Mladen Vučić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-4026</code><acronim><![CDATA[EfficientSDR]]></acronim><duration>01.10.2020 - 30.09.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>856294</team_members_id><team_members_names><![CDATA[ Doktorand: Katarina Vodvarka ]]></team_members_names><keywords_hr><![CDATA[programski definiran radio, obrada signala u komunikacijama, dizajn digitalnih sustava, višetaktna obrada signala, prostorna filtracija, UWB radio]]></keywords_hr><keywords_en><![CDATA[software defined radio, signal processing for communications, digital system design, multirate signal processing, spatial filtering, UWB radio]]></keywords_en><summary_hr><![CDATA[Od bežičnih komunikacijskih sustava neprestano se traži sve veća brzina prijenosa. Stoga se ovi sustavi moraju stalno unaprjeđivati. To je posebno slučaj kod radijskih podsustava koji često predstavljaju usko grlo cijelih prijenosnih lanaca. Programski definiran radio prepoznat je kao ključna tehnologija za njihov razvoj. Slijedeći ovaj trend, predloženi projekt razmatra poboljšavanje postojećih te razvoj novih postupaka za dizajn sustava za obradu signala koji se koriste u programski definiranom radiju. Konkretno, projekt je usmjeren na učinkovite višetaktne sustave, konvencionalne i prostorne filtre, te na sustave koji optimalno iskorištavaju spektar u ultra-širokopojasnom radiju. Od svih ovih sustava traži se učinkovita obrada signala, ali i učinkovita implementacija. S ciljem da se poveća učinkovitost, u istraživanjima će biti korištena sinteza u vremenskoj i frekvencijskoj domeni, sažeto očitavanje, polinomno izoštravanje, optimizacija, te niz drugih analitičkih i numeričkih tehnika. Kao rezultat projekta očekuju se novi postupci za dizajn sustava za višetaktnu obradu signala te novi postupci za dizajn sustava s rijetkim koeficijentima kao što su selektivni filtri, derivatori, integratori te sustavi sa stalnim i promjenjivim kašnjenjem. Nadalje, očekuje se doprinos u dizajnu antenskih polja koja omogućavaju robusno oblikovanje dijagrama zračenja te osiguravaju približno nezavisno upravljanje širinom snopa, usmjerenošću, razinom bočnih latica te dinamičkim rasponom koeficijenata. Konačno, očekuju se novi postupci za sintezu energetski i spektralno učinkovitih pulsova za ultra-širokopojasne komunikacije. Dobiveni postupci bit će izravno primjenjivi u razvoju komunikacijskih sustava. Nadalje, uključenost doktorskih studenata osigurat će visok obrazovni učinak te prijenos znanja u industrijsko okruženje. Svi ovi faktori su važni obzirom da se posljednjih godina komunikacijski sektor u Hrvatskoj intenzivno razvija.]]></summary_hr><summary_en><![CDATA[There is a constant need for the increase of transfer rate in wireless communication systems. Therefore, these systems must be continuously improved. This is particularly true for radio subsystems, which are often bottlenecks of entire communication chains. Software defined radio has been recognized as crucial technology for their development. Following this trend, the proposed project considers the improvement of existing and the development of new methods for the design of signal processing systems for software defined radio. In particular, the project is focused on multirate systems, conventional and spatial filters, as well as on the systems for optimal utilization of spectrum in ultra-wideband radio. Efficient signal processing and efficient implementation are required of all these systems. To increase the efficiency, the research will utilize time- and frequency-domain synthesis, compressed sensing, polynomial sharpening, optimization and various other analytical and numerical techniques. As project results, new methods are expected for the design of systems for multirate signal processing and for the design of systems with sparse coefficients such as selective filters, differentiators, integrators and systems with constant and variable delay. Furthermore, a contribution is expected in the design of antenna arrays that enable robust beamforming and provide nearly independent control of beamwidth, directivity, sidelobe level, and dynamic range ratio. Finally, new methods will be developed for the synthesis of energy- and spectral-efficient pulses for ultra-wideband communications. The resulting methods will be directly applicable in the development of communication systems. Furthermore, the involvement of doctoral students will ensure a high educational impact and the transfer of knowledge to the industrial environment. All of these factors are important because in recent years the communication sector in Croatia develops intensively.]]></summary_en></project><project>
<id>9536</id><title_hr><![CDATA[Platinom dekorirane čvrste otopine željezovog i kositrovog oksida za vodikove senzore]]></title_hr><title_en><![CDATA[]]></title_en><user_id>955</user_id><user_firstLast_name>Marijan Gotić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-7224</code><acronim><![CDATA[HydGasSens]]></acronim><duration>12.10.2022 - 24.03.2026</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>865744</team_members_id><team_members_names><![CDATA[ Doktorand: Izabela Đurasović ]]></team_members_names><keywords_hr><![CDATA[senzori vodika, kositar, zeljezo, čvrste otopine, XRD, Mossbauer, krmisorpcija, metalni oksidi]]></keywords_hr><keywords_en><![CDATA[hydrogen sensors, tin, iron, solid solution, XRD, Mossbauer, chemisorption, metal oxide]]></keywords_en><summary_hr><![CDATA[Mjerenje koncentracije vodikovog plina je važno u proizvodnji poluvodiča kao i u zrakoplovnoj i metalurškoj industriji. Među razvijenim senzorima vodika, oni koji se temelje na poluvodičkim metalnim oksidima privukli su pozornost zbog svoje relativno visoke osjetljivosti, dugog vijeka trajanja i termičke stabilnosti. U ovom projektu istraživat će se osjetljivost SnO2 i Fe2O3 i Fe2xSn2-2xO4-x uzoraka na plinoviti vodik. Dopiranje SnO2 željezovim ionima uzrokovat će promjene u parametrima jedinične ćelije, dužini kemijske veze, broju kisikovih vakancija i utjecat će na energijski procijep SnO2. Očekuje se da će formiranje čvrste otopine željezovog i kositrovog oksida (Fe2xSn2-2xO4-x) smanjiti radnu temperaturu osjetljivosti na vodik i imati blagotvoran učinak na osjetljivost senzora. Selektivnost prema vodiku poboljšat će se dekoriranjem platine (Pt) na površini sintetiziranih uzoraka. Mikrostrukturna svojstva sintetiziranih metalnih oksida optimizirat će se pomoću bezvodnog željezovog (II) i kositrovog (II) acetata. Dvovalentni kationi Fe (II) i Sn (II) će se oksidirati i hidrolizirati pomoću molekula vode nastalih &#39;&#39;in situ&#39;&#39; u reakciji esterifikacije između acetatnih skupina i etanola. Disperzija Pt klastera na sintetiziranim SnO2 i Fe2O3 i Fe2xSn2-2xO4-x uzorcima će se optimizirati upotrebom Pt (II) acetilacetonatnog prekursora. Ista skupina uzoraka bit će sintetizirana mehanokemijski kugličnim mljevenjem (sinteza u čvrstom stanju) i solvotermalnom sintezom pomoću mikrovalova (engl. bottom-up wet chemistry approach). Upotreba dvije različite tehnike sinteze omogućit će nam da odredimo optimalnu formulaciju čvrste otopine s najboljom Pt-disperzijom kako bismo dobili najbolje senzore vodikovog plina. Ovaj projekt može biti prvi korak u razvoju i proizvodnji novih materijala za senzore plina te u izgradnji komercijalno dostupnog sustava za mjerenje niskih koncentracija plina (senzori plinova).]]></summary_hr><summary_en><![CDATA[The hydrogen gas monitoring is important in numerous applications such as in the semiconductor manufacturing, aerospace applications and metallurgical processes. Among the developed hydrogen sensors, those based on semiconducting metal oxides have attracted attention due to their relative high sensitivity, long lifetime and thermal stability. In this project the hydrogen gas sensing properties of pristine SnO2 and Fe2O3 as well as of Fe2xSn2-2xO4-x solid solutions will be studied. SnO2 doping with iron will cause changes in lattice parameters and bond length, number of oxygen vacancies, and will have an impact on the narrowing SnO2 band gap. It is expected that the formation of iron tin oxide solid solution (Fe2xSn2-2xO4-x) will decrease sensor operating temperature and will have beneficial effect on the synthesized sensors sensitivity. The selectivity to hydrogen will be improved by platinum (Pt) decoration on the surface of synthesized samples. In this project the microstructural properties of synthesized metal oxide supports will be optimised using divalent anhydrous iron(II) and tin(II) acetates. The divalent Fe(II) and Sn(II) metal cations will be oxidised and hydrolysed using water molecules generated “in situ” in the esterification reaction between acetate groups and ethanol. The decoration of Pt clusters on the synthesized Fe2O3, SnO2 and Fe2xSn2-2xO4-x supports will be optimised using Pt(II) acetylacetonate precursor. The same set of samples will be synthesized using ball-milling (solid state synthesis) and microwave assisted solvothermal synthesis (bottom-up wet chemistry approach). Using two different synthesis techniques will enable us to determine the optimal solid solution formulation for the highest Pt-catalyst dispersion in order to accomplish the best hydrogen gas sensing properties. This project may be the first step in the development and production of new gas sensor materials and in the construction of commercially available gas-sensing system.]]></summary_en></project><project>
<id>9537</id><title_hr><![CDATA[STRATEGY CCUS (H2020 br. 837754) ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>992</user_id><user_firstLast_name>Daria Karasalihović Sedlar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-8850</code><acronim><![CDATA[]]></acronim><duration>07.10.2020 - 06.10.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Rudarstvo, nafta i geološko inženjerstvo, </scie_field_hr><scie_field_en>Mining, petroleum and geological engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Rudarsko-geološko-naftni fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mining, Geology and Petroleum Engineering]]></institution_en><team_members_id>858368</team_members_id><team_members_names><![CDATA[ Doktorand: Filip Vodopić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>9539</id><title_hr><![CDATA[Inovativna rješenja u katalitičkim proizvodnim procesima za potrebe farmaceutske industrije (CAT PHARMA)]]></title_hr><title_en><![CDATA[]]></title_en><user_id>227</user_id><user_firstLast_name>Robert Vianello</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-3482</code><acronim><![CDATA[]]></acronim><duration>01.11.2020 - 30.04.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>25938</team_members_id><team_members_names><![CDATA[ Doktorand: Lucija Hok ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>9543</id><title_hr><![CDATA[Molekularni aspekti patogenih procesa u AHCY deficijenciji]]></title_hr><title_en><![CDATA[]]></title_en><user_id>54</user_id><user_firstLast_name>Oliver Vugrek</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-2851</code><acronim><![CDATA[MAPinAD]]></acronim><duration>10.03.2021 - 15.05.2026</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>865294</team_members_id><team_members_names><![CDATA[ Doktorand: Katrin Nedeljko ]]></team_members_names><keywords_hr><![CDATA[Odgovor na oštećenje DNA, adenozin, stanični ciklus, karcinogeneza, bolest jetre, metastaza, transkriptomika]]></keywords_hr><keywords_en><![CDATA[DNA damage response, adenosine, cell cycle, cancerogenesis, liver disease, metastasis, transcriptomics]]></keywords_en><summary_hr><![CDATA[S-adenozilhomocistein hidrolaza (AHCY) katalizira hidrolizu S-adenozilhomocisteina (SAH) na adenozin (Ado) i homocistein (Hcs). Novija istraživanja ukazuju na povezanost AHCY i raka na nekoliko razina: AHCY može regulirati fenotipska obilježja stanica raka; AHCY kao ciljna molekula u terapijskim pristupima te kao biomarker za određena maligna oboljenja. Veza između adenozina (jednog od produkata hidrolize SAH) i raka jednim dijelom je poznata te uključuje stimulaciju proliferacije i ulogu u regulaciji upalnih/imunoloških procesa. Također, aktivnost AHCY u vezi je s razvojem patoloških promjena jetre, što potvrđuje i nedavno objavljen slučaj hepatocelularnog karcinoma kod pacijenta s nedostatnom aktivnošću AHCY.  Naši preliminarni podaci na stanicama hepatocelularnog karcinoma (HepG2) pokazuju da smanjena aktivnost AHCY uzrokuje sniženje razine Ado, uslijed čega dolazi do oštećenja DNA i zastoja u staničnom ciklusu. Iako navedeni podaci pokazuju ulogu AHCY u mehanizmima nastanka malignih oboljenja, točna molekularna podloga te veze nije razjašnjena. Da bismo je razjasnili, koristit ćemo &#39;multi-omics&#39; pristup, uz klasične metode kao što su analiza staničnog ciklusa, proliferacije i oštećenja DNA, na uzorcima tkiva i serumu pacijenata s patološkim promjenama jetre, odabranim staničnim linijama s utišanom ekspresijom AHCY, te na novorazvijenom transgeničnom mišu kao in vivo modelu.  Ispitat će se utjecaj sniženja razina adenozina (kao rezultat smanjene aktivnosti AHCY) na stanični metabolizam te predložiti mehanizam koji povezuje aktivnost AHCY, nastanak oštećenja DNA i regulaciju staničnog ciklusa. Rezultati predloženog istraživanja mogli bi unaprijediti terapijske pristupe u liječenju malignih oboljenja povezanih s smanjenom aktivnošću AHCY, te potaknuti razvoj novih metoda liječenja baziranih na regulaciji pomoću adenozina.]]></summary_hr><summary_en><![CDATA[S-adenosylhomocysteine hydrolase (AHCY) catalyzes the hydrolysis of S-adenosylhomocysteine (SAH) to Adenosine (Ado) and Homocysteine (Hyc). Recently, several studies pointed out connections of AHCY with cancer from various standpoints: as a player that possibly regulates cancer phenotype, as a druggable candidate, or, as a promising biomarker. Metabolome-wise, connections between adenosine and cancer have been established, showing stimulative effects on cell proliferation, and other important roles in inflammation or immunity. Implications of AHCY in hepatic pathology are well documented, and culminated in the recently reported case of hepatocellular carcinoma in an adult with AHCY deficiency. Also, as we have preliminary data showing that low AHCY activity and depletion of adenosine induces DNA damage and cell cycle arrest in hepatocellular carcinoma cells. In summary, involvement of AHCY in molecular mechanisms of cancer is undisputable. However, the molecular basis for the connection between AHCY and cancer is not quite obvious. In order to answers these questions we will deploy a multi-omics approach, in combination with basic molecular and cellular biology procedures focus on the role of AHCY and its mechanism of action on cell cycle, cellular proliferation and DNA damage response in histological and serum samples of liver disease patients, in relevant cancerous and AHCY deficient cell lines, and a unique mouse animal model. In particular, we will investigate the implications of adenosine, besides homocysteine, the primary product of AHCY hydrolytic activity on the cellular metabolism.  By answering these questions we hope to establish the mechanism that connects AHCY activity, DNA damage and regulation of cell cycle through adenosine levels. The outcomes of underlying research may lead to a refinement of therapeutical procedures for cancer as a result of AHCY malfunction, and a potentially new approach for targeted cancer therapy based on adenosine depletion. ]]></summary_en></project><project>
<id>9545</id><title_hr><![CDATA[Imunosni mehanizmi u razvoju upale i metaboličkog sindroma u debljini]]></title_hr><title_en><![CDATA[]]></title_en><user_id>7082</user_id><user_firstLast_name>Bojan Polić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-3606</code><acronim><![CDATA[INFLAMETAB]]></acronim><duration>15.10.2020 - 01.06.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Medicine]]></institution_en><team_members_id>856077</team_members_id><team_members_names><![CDATA[ Doktorand: Sanja Mikašinović ]]></team_members_names><keywords_hr><![CDATA[Upala, Debljina, Rezistencija na inzulin, metabolički sindrom, diabetes, NASH,  stanice NK, urođeni limfociti, gamma delta limfociti T, citokini]]></keywords_hr><keywords_en><![CDATA[Inflammation, Obesity, Insuline resistance, Metabolic Syndrome, diabetes, NASH, NK cells, ILCs, gamma delta T cells, macrophages, cytokines]]></keywords_en><summary_hr><![CDATA[Pretilost je jedan od najznačajnijih i rastućih medicinskih zdravstvenih problema današnjice. Procjenjuje se da trenutno na svijetu živi više od pola milijarde debelih ljudi i  preko milijarde onih s prekomjernom težinom. Značajan broj njih oboljeva od šećerne bolesti tipa 2 (DM2) i nealkoholne bolesti masne jetre (NAFLD), koje često koegzistirjau i dijele patogene abnormalnosti debljine kao što su rezistencija na inzulin (IR), dislipidemija i hipertenzija, što su karakteristike metaboličkog sindroma. Debljina je povezana sa kroničnom sistemskom upalom niskog intenziteta za koju se smatra da je važan pozadinski uzrok IR, koja dovodi do DM2 i NAFLD. Ciljanje mehanizama upale u obje bolesti je stoga obećavajuće za buduće pristupe u terapiji. No, stvarni mehanizmi koji induciraju ili pogoršavaju upalu u debljini i uzrokuju prijelaz iz stadija pre-dijabetesa u DM2 ili iz stadija jetrene steatoze u nealkoholni steatohepatitis (NASH) su još uvjek uglavnom nejasni. Stoga je bolje poznavanje imunosnih uzroka DM2-a i NASH-a neophodno potrebno. U ovom projektu namjeravamo istražiti imunosne mehanizme koji su važni za indukciju upalnih procesa u visceralnom masnom tkivu (VAT) i jetri, te su odgovorni za razvoj DM2 i NASH. Dodatno, naš cilj je istražiti virusne faktore koji pogoršavaju IR i imaju učinak na tranziciju iz pre-dijabetesa u DM2. U ovoj studiji koristi ćemo dobro pozate mišje modele dijetom inducirane debljine (DIO), te odgovarajuće mišje mutante i druga oruđa kako bismo odgovorili na postaljena pitanja. Isto tako, usporediti ćemo eksperimentalne podatke sa podacima analize uzoraka sakupljenih od pretilih bolesnika što je također planirano projektom. Ovaj projekt povezuje imunologiju, virologiju i endokrinologiju. Istraživački tim ima dovoljno iskustva i znanja za uspješno provođenje predloženog istraživanja, te će bti sposoban stvoriti nova vrijedna i korisna saznanja o razvoju DM2-a i NASH-a. ]]></summary_hr><summary_en><![CDATA[Obesity is one of the most prominent and growing health problem of our time. It is estimated that more than a half billion of obese and another billion of overweight people live currently in the world. A significant number of them develop Diabetes Mellitus type 2 (DM2) and Non-alcoholic Fatty Liver Disease (NAFLD), which often coexist and share pathogenic abnormalities of obesity like insulin resistance (IR), dyslipidaemia and hypertension, which are features of the metabolic syndrome. Obesity is associated with a chronic systemic low-grade inflammation which is thought to be an important underlying cause of IR that leads to DM2 and NAFLD. Targeting of the underlying mechanisms of inflammation in both diseases therefore holds much promise for future therapies. However, the exact mechanisms that induce or aggravate inflammation and trigger transition from pre-diabetes to DM2 or from hepatic steatosis to non-alcoholic steatohepatitis (NASH) in obesity are still largely unclear. A better understanding of immunological causes of DM2 and NASH is therefore required.In this project we aim to investigate immune mechanisms that are important for induction of inflammatory processes in visceral adipose tissue (VAT) and liver, which are responsible for development of DM2 and NASH. In addition, our goal is to investigate viral factors that aggravate IR such as impact progression from pre-diabetes to DM2. In our study we will use well established mouse models of diet induced obesity (DIO) and appropriate mouse mutants and tools to address raised questions. We will compare experimental data with the analysis of samples collected from obese human subjects also planned in the project. Our project bridges immunology, virology and endocrinology. Our team has enough experience and expertise to drive successfully proposed research and will be able to provide valuable new insights in the development of DM2 and NASH. ]]></summary_en></project><project>
<id>9548</id><title_hr><![CDATA[Teme i aspekti hrvatske fotografije od 19. stoljeća do danas]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3151</user_id><user_firstLast_name>Sandra Križić Roban</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-8525</code><acronim><![CDATA[]]></acronim><duration>01.11.2020 - 30.04.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Povijest umjetnosti, </scie_field_hr><scie_field_en>Art history, </scie_field_en><institution_hr><![CDATA[Institut za povijest umjetnosti]]></institution_hr><institution_en><![CDATA[Institute of Art History, Zagreb]]></institution_en><team_members_id>858419</team_members_id><team_members_names><![CDATA[ Doktorand: Lana Lovrenčić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>9549</id><title_hr><![CDATA[Strukturiran ekološki uzgoj primjenom autonomnih robota u staklenicima]]></title_hr><title_en><![CDATA[]]></title_en><user_id>21420</user_id><user_firstLast_name>Matko Orsag</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-5787</code><acronim><![CDATA[SPECULARIA]]></acronim><duration>01.10.2020 - 20.11.2025</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>858415</team_members_id><team_members_names><![CDATA[ Doktorand: Jelena Tabak ]]></team_members_names><keywords_hr><![CDATA[Robotski sustavi, Bespilotne letjelice, Mobilna robotika, Podatni sustavi, Nelinearno upravljanje, Planiranje putanje, Planiranje zadataka ]]></keywords_hr><keywords_en><![CDATA[Robotic systems, Unmanned aerial vehicles, Mobile robotics, Compliant systems, Nonlinear control, Path planning, Path planning ]]></keywords_en><summary_hr><![CDATA[Cilj ovog projektnog prijedloga jest uspostaviti istraživačku grupu pri Fakultetu elektrotehnike i računarstva Sveučilišta u Zagrebu s istraživačkim fokusom na dvije posebno aktualne grane robotskog istraživanja, podatne manipulacije i heterogenih robotskih sustava. Predložene teme su trenutno jedne od najvećih pokretača istraživanja u robotici, te su pronašle svoju primjenu u različitim granama, počevši od medicine i industrije, pa sve do svemirske robotike. Budući da su ambiciozni praktični problemi, često najbolji pokretači istraživanja, za testiranje predloženih algoritama i ispitivanje sustava predložen je interdisciplinarni scenarij primjene heterogenog robotskog sustava u staklenicima organske poljoprivrede. Predloženim projektom planira se zaposliti i usavršiti doktorand i poslijedoktorand, odnosno educirati više generacija studenata fakulteta kroz rad na projektu. Uspješan nastavak rada na predloženoj temi, predviđen je, uz potporu Inovacijskog Centra Nikola Tesla, razvojem grupe u dva smjera: temeljno istraživanje i industrijsko primjenjivo istraživanje. Interdisciplinarnost projekta očituje se kroz horizontalnu temu poljoprivrede, a osigurana je potporom tvrtke Agrivi koja će pružiti svoje znanje i iskustvo.]]></summary_hr><summary_en><![CDATA[The main goal of this proposal is to establish a research group capable of performing internationally relevant research in the field of compliant robot control and heterogeneous robotic system in general, within the University of Zagreb Faculty of Electrical Engineering and Computing. These emerging topics are one of the most powerful drivers of robotic research. They are applied to various fields of research, including medical, industrial and even space robotics. Because, often enough practical problems are the best drivers of research, the project proposes validating these robotics research topics, in a scenario involving a heterogeneous robotics system utilized to help farmers in indoor organic agriculture. Project aim to employ and educate a PhD student and a Postdoctoral researcher, as well as offer undergraduate students an opportunity to work and learn on cutting edge robotics problems. Proposed three stage development of the group, in both basic technology research and industrial application, through the help of Innovation Center Nikola Tesla, will make sure the group continues the develop after the proposed project has ended. Interdisciplinary characteristic of the proposal is manifested through the application to agriculture and supported by a Croatian ICT company Agrivi, specialized in agriculture.]]></summary_en></project><project>
<id>9550</id><title_hr><![CDATA[Modulacija polifenolnog profila voća uslijed fizikalnih tretmana nakon branja]]></title_hr><title_en><![CDATA[Modulation of fruit polyphenolic profile by sustainable postharvest physical treatments]]></title_en><user_id>234</user_id><user_firstLast_name>Davor Kovačević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IPS</proposal_type><proposal_call>2020-01</proposal_call><code>IPS-2020-01-6126</code><acronim><![CDATA[APPLPEMs]]></acronim><duration>15.10.2020 - 14.01.2024</duration><status>Završio</status><financ_value>135.775,43 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>24520, 836, 1015, 29114, 21288, 866636, </team_members_id><team_members_names><![CDATA[Tin Klačić, Danijel Namjesnik, Jasmina Jukić, Katarina Jerin, Juraj Nikolić, Mia Mesić, ]]></team_members_names><keywords_hr><![CDATA[polielektroliti, višeslojevi, ionski efekti, prevlake, jabuke]]></keywords_hr><keywords_en><![CDATA[polielectrolytes, multilayers, ionic effects, coatings, apples]]></keywords_en><summary_hr><![CDATA[Polielektrolitni višeslojevi (eng. polyelectrolyte multilayers, PEM) su površinske prevlake koje nastaju naizmjeničnom adsorpcijom pozitivno i negativno nabijenih polielektrolita na čvrstu površinu. Uz fundamentalna istraživanja, posljednjih se godina polielektrolitni višeslojevi intenzivno istražuju i zbog njihove potencijalne primjene u industriji, medicini i biotehnologiji. Glavni su ciljevi predloženog projekta dodatno razjašnjenje mehanizama nastajanja i svojstava polielektrolitnih višeslojeva s posebnim naglaskom na utjecaje ionskih efekata na navedeni proces, te primjena dobivenih rezultata na istraživanje prevlaka za zaštitu svojstava jabuka. Glavna hipoteza projekta je da bolje razumijevanje ionskih utjecaja može dovesti do kreiranja polielektrolitnih višeslojeva unaprijeđenih svojstava što bi omogućilo pripravu učinkovitijih filmova. Upotreba različitih soli može dovesti do nastajanja polielektrolitnih višeslojeva s različitim hidratacijskim svojstvima, a poznato je da hidratacija utječe i na procese adhezije. S druge strane, soli mogu utjecati i na dinamiku lanca i posljedično samo-obnavljanje. Predloženi projekt sastoji se od tri međusobno povezana cilja: 1. Karakterizacija modelnih supstrata za formiranje polielektrolitnih višeslojeva, 2. Dizajn, priprava i karakterizacija polielektrolitnih višeslojeva i 3. Primjena polielektrolitnih višeslojeva kao prevlaka za zaštitu voća. Kod cilja 3) u svrhu optimiziranja primjene koristit će se rezultati ostvareni u cilju 1) i 2). Detaljna karakterizacija polielektrolitnih višeslojeva provest će se nizom naprednih komplementarnih metoda (npr. elipsometrija i AFM), a značajan uvid u svojstva jabuka prekrivenih polielektrolitnim višeslojevima bit će dobiven odgovarajućim mikroskopskim eksperimentima.]]></summary_hr><summary_en><![CDATA[Polyelectrolyte multilayers (PEMs) are surface coatings formed by alternating adsorption of positively and negatively charged polyelectrolytes on a solid surface. Additional to the fundamental research, polyelectrolyte multilayers have been intensively investigated in recent years due to their potential applications in industry, medicine and biotechnology. The main goals of the proposed project are further understanding of the mechanisms of formation and properties of polyelectrolyte multilayers with a special emphasis on the effects of ionic effects on the process, as well as the application of the obtained results to the research of the coatings that could be used for the protection of apples. The main hypothesis is that the better understanding of the ionic effects can lead to the creation of PEMs with better and adjustable properties that will then enable the formation of more efficient coatings. Using different salts might create PEMs having different hydration properties and hydration has been known to impact adhesion processes. On the other hand, salts can impact the chain dynamics and therefore self-healing.The proposed project consists of three interconnected: 1. Characterization of model substrates for formation of polyelectrolyte multilayers, 2. Design, preparation and characterization of polyelectrolyte multilayers and 3. Application of polyelectrolyte multilayers as apple coatings. In objective 3), in order to optimize possible applications, the results obtained in objectives 1) and 2) will be used. The detailed characterization of polyelectrolyte multilayers will be carried out through a series of advanced complementary methods (e.g. ellipsometry and AFM) and a significant insight into the properties of polyelectrolyte multilayer coated apples will be obtained by microscopic experiments.]]></summary_en></project><project>
<id>9555</id><title_hr><![CDATA[Globalni Humanizmi: Novi Pogledi na Srednji Vijek (300- 1600)]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5939</user_id><user_firstLast_name>Miljenko Jurković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-2336</code><acronim><![CDATA[GLOHUM]]></acronim><duration>01.10.2020 - 30.09.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Povijest umjetnosti, </scie_field_hr><scie_field_en>Art history, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>856225</team_members_id><team_members_names><![CDATA[ Doktorand: Filip Lovrić ]]></team_members_names><keywords_hr><![CDATA[globalni humanizmi, srednjovjekovni humanizmi, srednjovjekovne renesanse, dvorska umjetnost, srednji vijek u dugom trajanju]]></keywords_hr><keywords_en><![CDATA[global humanisms, medieval humanisms, medieval renaissances, the art of the court, the long lasting middle ages (longue duree)]]></keywords_en><summary_hr><![CDATA[Teza je pokazati da je humanizam već srednjovjekovni koncept, koji se manifestira u nizu renesansi, a ne invencija s početka ranog novog vijeka. Cilj je  ponuditi novu i drugačiju povijest srednjega vijeka, koja se rigoroznom i metodičkom primjenom interdisciplinarnog pristupa odmiče od ograničenja tradicionalne periodizacije. Umjesto „mračnog srednjeg vijeka“ nudi se vizija humanističkog srednjeg vijeka u „dugom trajanju“ (300-1600). Istraživanja potvrđuju teorijsku utemeljenost ideje da se kroz djela „dvorske umjetnosti“ manifestira niz renesansi (Konstantinova, Teodozijeva, Sixtova, Justinijanova, Teodolindina, Liutprandska, Karolinška, Otonska, renesansa 11. st., pa 12. st., stil 1200., rana gotika, vernakularni stil), pokazujući da se antički „humanizmi“ prenose djelovanjem intelektualnih elita. Ciljevi su ispitati tezu dijakronijski, kroz razdoblja od kasne antike do gotike, istražiti je i povezati kroz različite vidove umjetničkog izraza: pisane riječi, likovnih umjetnosti, arhitekture i urbanizma. Metodološki pristup u rasponu je od terenskog (arhivski rad, rekognosciranje, snimanje, katalogizacija građe, 3D rekonstrukcije) do komparativnog (renesanse u europskom prostoru). Potom će se dobivene rezultate povezati da bi se razvio model sekvenciranja srednjovjekovnih renesansi. U metodološkom smislu  interdisciplinarnost je ključna.Rezultati spoznaja će se istovremeno primijeniti na tradicionalno razdoblje renesanse 16. st., koju bismo mogli označiti kao kulminaciju svih prethodnih. Projekt time uključuje globalnu, izvan-europsku dimenziju renesanse, jer će se pažnja usredotočiti na transatlantski, habsburški imperij.Očekivani je rezultat unaprijediti saznanja o srednjem vijeku u dugom trajanju. Dodatni učinci proizlaze iz korištenja novih tehnologija - sve će biti dostupno korisnicima, službama zaštite spomenika, lokalnim zajednicama na istraživanim prostorima, za edukaciju i bolje donošenje odluka u očuvanju kulturne baštine.]]></summary_hr><summary_en><![CDATA[The thesis is to show that “humanism” is already a medieval notion and not an invention of early modernity. The goal is to write “a history of the Middle Ages” - one possible new, different history. A rigorous and methodological interdisciplinary approach intends to emancipate it from the constraints of traditional periodization. Instead of a dark Middle Ages, a humanistic Middle Ages, spanning the late antiquity and the Classical Age. Research has proven that, through the works of the “Arts of the Court,” there existed a sequence of renaissances (Constantine’s, Theodosian, Sixtus’, Justinan’s, Theodolinda’s, Liutprand’s, Carolinginan, Ottonian, Renaissance of 11th C., Renaissance of 12th C., The Style 1200, Early Gothic, Vernacular Style), evidence that Classical “humanisms” are translated through the actions of intellectual elites. The goal is to test the hypothesis diachronically, through all periods from Late Antiquity to Gothic, and synchronically through means of artistic expression: the written word, visual arts, architecture and urbanism. The methodological approach ranges from field research (work in archives, territory survey, recording, cataloguing, 3D) to comparative analysis of renaissances in Europe. Data and results will be merged to develop a model of sequencing medieval renaissances. Here an interdisciplinary approach is essential to the methodology. These findings will also be applied to the traditionally defined period of the 16th c. Renaissance, seen as the culmination of all the preceding ones. The project therefore includes an extra-European, global dimension for the Renaissance by focusing on the trans-Atlantic, Habsburg empire.The expected result is to improve our knowledge of the medieval period in the longue durée. The additional impact stems from the use of new technologies: all data will be available to users, heritage protection offices, and local communities in order to educate and to improve the decision making in CH preservation.]]></summary_en></project><project>
<id>9556</id><title_hr><![CDATA[Rasvjetljavanje evolucije satelitnih DNA visokoprotočnim analizama satelitoma srodnih vrsta]]></title_hr><title_en><![CDATA[]]></title_en><user_id>332</user_id><user_firstLast_name>Brankica Mravinac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-2690</code><acronim><![CDATA[EvoSat]]></acronim><duration>01.11.2020 - 30.04.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>858410</team_members_id><team_members_names><![CDATA[ Doktorand: Damira Veseljak ]]></team_members_names><keywords_hr><![CDATA[satelitom, satelitna DNA, Tribolium, kamenice, evolucija ponovljenih DNA]]></keywords_hr><keywords_en><![CDATA[satellitome, satellite DNA, Tribolium, oysters, repetitive DNA evolution]]></keywords_en><summary_hr><![CDATA[Uzastopno ponovljene sekvence DNA, poznate kao satelitne DNA (satDNA), najčešće smještene u heterokromatinskim regijama, čine značajne dijelove eukariotskih genoma. Desetljećima je biološka važnost satDNA bila osporavana prvenstveno zbog njihove nekodirajuće prirode, ali u novije vrijeme otkriva se značajna uloga satDNA u strukturi centromera, remodeliranju kromatina, specijacijskim procesima, kao i u tumorogenezi. Zbog uzastopne ponovljenosti ove sekvence DNA mahom su izostavljene u genomskim projektima. U posljednjih nekoliko godina, visokoprotočno sekvenciranje i pripadajući specijalizirani računalni alati stubokom mijenjaju studije satDNA, omogućavajući otkrivanje ukupnog sadržaja satDNA u genomu, nazvanog satelitom. Glavni cilj našeg projekta je istražiti satelitome dviju skupina beskralješnjaka: (i) kukaca roda Tribolium, čije genome karakteriziraju iznimno bogate satDNA smještene u velikim heterokromatinskim domenama te (ii) školjkaša, za koje je poznato da imaju nizak udio satDNA te kromosome bez velikih heterokromatinskih blokova. U svrhu istraživanja satelitoma osam vrsta, kombinirajući Illumina i PacBio sekvenciranje s različitim eksperimentalnim metodama, proučit ćemo: (i) vrsno-specifične i grupno-specifične satDNA, (ii) dinamiku i kromosomsku distribuciju satDNA sekvenci, (iii) organizacijske obrasce satDNA sljedova, (iv) postojanje i očuvanost potencijalno funkcionalnih motiva u sekvencama satDNA, (v) sličnosti i povezanost satDNA s mobilnim elementima. Očekujemo da ćemo sveobuhvatnim istraživanjem satelitoma dviju različitih skupina beskralješnjaka i usporednom analizom dobivenih podataka unaprijediti trenutne spoznaje o strukturi i evoluciji satDNA, uključujući životni ciklus, porijeklo i sudbinu, kao i moguće mehanizme nastanka i širenja uzastopnih ponavljanja te razjasniti veze između satDNA i mobilnih elemenata.]]></summary_hr><summary_en><![CDATA[Tandemly repeated DNA sequences, known as satellite DNAs (satDNAs), constitute significant portions of eukaryotic genomes, being usually located in genetically silent heterochromatin. SatDNA biological relevance has been disregarded for decades mostly due to their non-coding character but it is coming to light that these sequences play important roles in centromere structure, chromatin remodelling, speciation processes, as well as in tumorigenesis. Repetitiveness of satDNAs, that impedes contiguous sequence assemblies, has kept them underrepresented in genome project outputs. Recently, however, high-throughput sequencing accompanied by specialized computational tools has revolutionized satDNA studies enabling discovery of a whole set of satDNAs in a genome, named a satellitome. The main goal of this project is to investigate the satellitomes in two groups of invertebrates: (i) beetles of the genus Tribolium, characterized by highly abundant satDNAs located in large heterochromatic chromosomal domains, and (ii) bivalve species, known to have low satDNA contribution and chromosomes mostly devoid of large heterochromatic blocks. By engaging Illumina and PacBio sequencing combined with experimental methods to study satellitomes of eight species, our work will address: (i) shared and species-specific satDNAs, (ii) satDNA sequence dynamics and chromosomal distribution in the analysed satellitomes, (iii) sequential patterns of satellite repeats, (iv) existence and conservation of potentially functional motifs in satDNA sequences, and (v) satDNA similarities and association with transposable elements (TEs). By comprehensive surveys of satDNA concepts in two different invertebrate groups and ensuing data interlacing, we expect to further current ideas about satDNA structure and evolution, including the life-cycle, origin and destiny of satellite repeats, links between satDNAs and TEs, as well as possible mechanisms involved in the formation and spread of tandem repeats. ]]></summary_en></project><project>
<id>9561</id><title_hr><![CDATA[ODRŽIVA GRADNJA NASUTIH PLAŽA – GRADNJA NOVIH I POVEĆANJE KAPACITETA POSTOJEĆIH]]></title_hr><title_en><![CDATA[]]></title_en><user_id>18928</user_id><user_firstLast_name>Igor Ružić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-8758</code><acronim><![CDATA[BEACHEX]]></acronim><duration>03.11.2020 - 02.11.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Građevinarstvo, </scie_field_hr><scie_field_en>Civil engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Građevinski fakultet u Rijeci]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Civil Engineering]]></institution_en><team_members_id>858425</team_members_id><team_members_names><![CDATA[ Doktorand: Andrea Tadić ]]></team_members_names><keywords_hr><![CDATA[dohrana plaža, nasipavanje plaža, erozija plaža, utjecaj nasipavanja na okoliš, utjecaj nasipavanja na biocenozu,baza podataka plaža ]]></keywords_hr><keywords_en><![CDATA[beach nourishment, beach filling, beach erosion, enviromental impact of filling, beach database]]></keywords_en><summary_hr><![CDATA[Hrvatske plaže su pod pritiskom turizma s jedne strane gdje se teži povećanju kapaciteta plaža te utjecaja klimatskih promjena s druge strane koje povećavaju erozijski potencijal olujnih valova. Na strateškoj razini, Hrvatska provodi osnovne mjere s ciljem učinkovitog upravljanja plažama ali u tom procesu nedostaje tehnička podrška. Upravo definiranje tehničke podrške za potrebe dugoročnog nasipavanja postojećih i novih žala u Hrvatskoj s minimalnim utjecajem na okoliš je cilj ovog projekta. U okviru projekta planira se izraditi sveobuhvatna baza lokacija (podataka) na kojima se vrši nasipavanje u svrhu povećanja kapaciteta plaža. Na bazi opsežnog terenskog mjerenja, planira se rasvijetliti morfološke procese na nasutim plažama u uvjetima jadranske valne klime te razviti jednostavan inženjerski alat za tehničke proračune (SHINGLE model). Utjecaj na okoliš, odnosno podmorsku biocenozu, će se istražiti kroz pet ronilačkih pregleda na plažama na kojima se vrši redovito nasipavanje. Primjenom numeričkog modeliranja definirat će se tehničke mjere potrebne da bi se dugoročno minimizirao gubitak materijala iz nasutih žala te mjere za umanjenje utjecaja klimatskih promjena. Edukacija relevantnih dionika (tehničko osoblje županija, gradova i općina) će se osigurati kroz provedbu dviju radionica u primorskim županijama. Diseminacija znanstvenih rezultata će se obaviti kroz publikaciju četiri znanstvena rada te pet konferencijskih izlaganja.]]></summary_hr><summary_en><![CDATA[Beaches in Croatia are under the pressure due to tourism development from one side which tends to growth the beach capacities and from the other side due to influence of climate changes which enlarge erosion potential of storm waves. At the strategic level, Croatia implements basic measures to effectively manage beaches but, in that process, technical support lacks. Definition of the technical support for the needs of long-term nourishing of the existing and filing of the new beaches in Croatia with minimal environmental impact is the goal of this project. Within the project it is planned to create a comprehensive database of sites where filling is used to apply along the Croatian coast. Based on the extensive field measurements, it is planned to research the morphological processes on the gravel beaches in wave conditions of the Adriatic Sea and to develop a simple engineering tool for technical calculations (SHINGLE model). The impact on the environment, i.e. on the underwater biocenosis, will be investigated through five dive examinations at beaches where regular nourishment takes place. Applying numerical modeling, the technical measures needed to minimize the loss of material from the beaches in long-term conditions will be defined and measures to mitigate the impact of climate changes. Education of relevant stakeholders (technical staff of counties, cities and municipalities) will be ensured through the implementation of two workshops in coastal counties. Dissemination of scientific results will be carried out through the publication of four scientific papers and five conference presentations.]]></summary_en></project><project>
<id>9566</id><title_hr><![CDATA[Hibridno sušenje i valorizacija biljnog prehrambenog otpada i nusproizvoda]]></title_hr><title_en><![CDATA[]]></title_en><user_id>448</user_id><user_firstLast_name>Suzana Rimac Brnčić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-1323</code><acronim><![CDATA[HYDRYBY]]></acronim><duration>20.10.2020 - 19.10.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Prehrambena tehnologija, </scie_field_hr><scie_field_en>Food technology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Food Technology and Biotechnology]]></institution_en><team_members_id>858359</team_members_id><team_members_names><![CDATA[ Doktorand: Roko Marović ]]></team_members_names><keywords_hr><![CDATA[Vakuum-kondukcijsko sušenje, mikrovalno-konvekcijsko sušenje, ultrazvuk, visoki hidrostatski tlakovi, karoteni, bundeva, avokado, izoterme sorpcije]]></keywords_hr><keywords_en><![CDATA[Vacuum-conductive drying, microwave-convective drying, ultrasound, high hydrostatic pressures, carotenes, pumpkin, avocado, sorption isotherms]]></keywords_en><summary_hr><![CDATA[Sušenje je jedan od najstarijih procesa konzerviranja hrane. Dostupne su brojne tehnike sušenja različitih sirovina kako bi se dobili proizvodi visoke kvalitete i produljenog roka trajanja. U prehrambenoj industriji,  konvekcijsko sušenje u struji vrućeg zraka i dalje je jedna je od najčešćih tehnoloških operacija za dobivanje suhog proizvoda. Međutim, konvekcijsko sušenje ima određene nedostatke i ograničenja u pogledu kvalitete proizvoda i energetske učinkovitosti. U novije vrijeme, navedena ograničenja mogu se svesti na najmanju moguću mjeru uvođenjem kombinacije inovativnih netoplinskih tehnologija i hibridnog sušenja. Ultrazvučna predobrada i predobrada visokim tlakovima mogu dovesti do pozitivnih  fizikalno-kemijskih promjena, kao i poboljšati prijenos mase. Hibridno sušenje predstavlja kombinirani postupak sušenja koji koristi više tehnika sušenja, a može djelovati sinergijski te rezultirati kraćim vremenom sušenja i manjom potrošnjom energije uz zadržavanje kvalitativnih svojstava sušenog materijala. Cilj ovog projekta je istražiti utjecaj inovativnih tehnologija predobrade (ultrazvuk, visoki tlakovi) na učinkovitost sušenja, fizikalno-kemijska i nutritivna svojstva nedovoljno iskorištenog otpada avokada  i nusproizvoda bundeve  u definiranim uvjetima sušenja u hibridnoj kondukcijsko-vakuumskoj sušari i hibridnoj mikrovalno-konvekcijskoj sušari. Tijekom proizvodnje i skladištenja posebno su važna sorpcijska svojstva osušenog materijala te će stoga biti razvijeni različiti kinetički modeli  koji će se koristiti za odabir odgovarajućih uvjeta skladištenja i pakiranja i na taj način optimirati zadržavanje  poželjnih svojstava boje, teksture, hranjivih tvari i bioloških aktivnih spojeva, kao i uvjete sušenja i rehidratacije osušenog materijala.]]></summary_hr><summary_en><![CDATA[Drying is one of the oldest food preservation process. There are numerous drying techniques offered to dehydrate different kinds of raw materials in order to obtain products of a high quality and extended shelf-life. In food processing, convective hot-air drying is still one of the most extensively used method for dehydration of food products. However, it has some disadvantages and limitations regarding product quality and energy efficiency. Those limitations might be minimized by introducing the combination of the innovative non-thermal pretreatment technologies and hybrid drying technologies. Ultrasound and high pressure pretreatments could provide some beneficially physical or chemical changes as well as to enhance mass transport. Hybrid drying, a combined drying approach which utilizes more drying techniques, can provide a synergistic effect resulting in decreased drying time and energy consumption while maintaining most quality attributes.  The objective of this project is to investigate the effect of innovative pre-treatment technologies  (ultrasound, high pressures) on the drying efficiency, physico-chemical and nutritive properties of underutilized avocado waste and pumpkin byproducts in defined drying conditions in a hybrid conductive-vacuum dryer and a hybrid microwave-convective dryer. Particularly important during production and storage of the dried material are the sorption properties.  Different kinetic models will be developed. Such data can be used for selecting appropriate storage conditions and packaging systems that optimize the retention of color, texture, nutrients and biologically active compounds as well as optimize the drying or rehydration conditions of a dried material.]]></summary_en></project><project>
<id>9568</id><title_hr><![CDATA[Biokonverzija lignoceluloznog materijala u visokovrijednu hranu za životinje (Bio4Feed)]]></title_hr><title_en><![CDATA[]]></title_en><user_id>309</user_id><user_firstLast_name>Marina Tišma</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-5257</code><acronim><![CDATA[]]></acronim><duration>01.10.2020 - 20.01.2026</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Biotehnologija, </scie_field_hr><scie_field_en>Biotechnology, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Prehrambeno-tehnološki fakultet]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Food Technology]]></institution_en><team_members_id>856192</team_members_id><team_members_names><![CDATA[ Doktorand: Anđela Zeko-Pivač ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>9569</id><title_hr><![CDATA[SeaClear - Search, Identification and Collection of Marine Litter with Autonomous Robots]]></title_hr><title_en><![CDATA[]]></title_en><user_id>19770</user_id><user_firstLast_name>Ivana Palunko</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-8228</code><acronim><![CDATA[]]></acronim><duration>02.11.2020 - 01.11.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Dubrovniku]]></institution_hr><institution_en><![CDATA[University of Dubrovnik]]></institution_en><team_members_id>862795</team_members_id><team_members_names><![CDATA[ Doktorand: Antun Đuraš ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>9570</id><title_hr><![CDATA[Razvoj multifunkcionalnog antiterorističkog sustava (MAS)]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5962</user_id><user_firstLast_name>Nikola Mišković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-2247</code><acronim><![CDATA[]]></acronim><duration>01.10.2020 - 31.03.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>856248</team_members_id><team_members_names><![CDATA[ Doktorand: Vladimir Slošić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>9571</id><title_hr><![CDATA[Store4HUC – Integration and smart management of energy storages at historical urban sites]]></title_hr><title_en><![CDATA[]]></title_en><user_id>7616</user_id><user_firstLast_name>Vinko Lešić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-4559</code><acronim><![CDATA[]]></acronim><duration>01.10.2020 - 30.09.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>861739</team_members_id><team_members_names><![CDATA[ Doktorand: Filip Vrbanc ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>9572</id><title_hr><![CDATA[Formalno rasuđivanje i semantike]]></title_hr><title_en><![CDATA[]]></title_en><user_id>21409</user_id><user_firstLast_name>Tin Perkov</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-2593</code><acronim><![CDATA[FORMALS]]></acronim><duration>09.11.2020 - 09.05.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Učiteljski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Teacher Education]]></institution_en><team_members_id>858383</team_members_id><team_members_names><![CDATA[ Doktorand: Tin Adlešić ]]></team_members_names><keywords_hr><![CDATA[matematička logika, modalna logika, teorija modela, logika u računarstvu, formalno rasuđivanje]]></keywords_hr><keywords_en><![CDATA[mathematical logic, modal logic, model theory, logic in computer science, formal reasoning]]></keywords_en><summary_hr><![CDATA[Projekt će uspostaviti novu istraživačku grupu u području matematičke logike, s ciljem uspostave suradnje među istraživačima čiji dosadašnji rezultati su pretežno teorijski s istraživačima koji su se u dosadašnjem znanstvenom radu fokusirali na primjene. Stoga je naglasak projekta na međusobnoj komunikaciji i diseminaciji, kao i usavršavanju doktoranada koji će se od samog početka znanstvene karijere poticati da razviju ovaj interdisciplinarni pogled. Sadržajno, cilj projekta je međusobno obogaćivanje teorijske i primijenjene logike s naglaskom na primjene logike u računarstvu, ali i obratno, primjene računalnih alata u logičkom i matematičkom istraživanju. Drugi cilj je primjena logike u konkretnim problemima lingvistike ili, općenitije, kognitivnih i informacijskih znanosti, pa i interdisciplinarnih područja u kojima se preklapaju ekonomija i matematika (teorija igara, teorija društvenog izbora). Na prvi pogled vrlo formalna i teorijska disciplina, logika je izrazito primjenjiva, a iznenađuje primjena istih ili sličnih logičkih sistema, osobito modalne logike, u vrlo različitim područjima. Formalizacija donosi pojmovnu preciznost i jasnoću, što omogućuje sigurnost u dokazivanju novih spoznaja, ali i rasvjetljuje kompleksnost problema i otkriva nova pitanja koja u neformalnom rasuđivanju mogu ostati skrivena. Teorijski aspekti projekta obuhvaćaju: 1) istraživanje izražajne snage formalnih jezika metodama teorije modela, 2) adekvatnost i potpunost, odlučivost i složenost logičkih sistema, osobito modalne logike, 3) istraživanje mogućnosti razvoja apstraktne teorije formalnih semantika. Aspekti primjene su: 1) razvoj, istraživanje i formalizacija matematičkih modela za probleme drugih disciplina, 2) razvoj i implementacija algoritama, 3) otkrivanje veza među pitanjima iz prividno različitih područja preko srodnih formalizacija. Projekt predviđa interdisciplinarnu i međunarodnu suradnju.]]></summary_hr><summary_en><![CDATA[A new research group in mathematical logic will be established, with the aim of collaboration between researchers whose previous results were mainly in pure logic and those who previously focused on applications. The emphasis of the project is on mutual communication and dissemination, and training of doctoral students who will be encouraged to develop this interdisciplinary approach from the very beginning of their career. The goal of the project is mutual enrichment of pure and applied logic, with emphasis on applications of logic in computer science, and vice versa, the application of computational tools in logical and mathematical research. Another goal is to apply logic to specific problems of linguistics or, more generally, cognitive and information sciences, as well as interdisciplinary areas in which economics and mathematics overlap (game theory, social choice theory). Even though logic is at the first glance a formal and theoretical discipline, logic is also exceptionally applicable, and it is surprising to see applications of the same or similar formal systems, especially modal logics, in a variety of areas. Formalization brings conceptual precision, clarity and confidence. Formalization also provides new insights of the complexity of problems and allows for discovery of new issues that remain hidden in informal reasoning. The theoretical aspects of the project include: 1) exploring the expressive power of formal languages by methods of model theory, 2) soundness and completeness, decidability and complexity of formal systems, especially modal logics, 3) exploring the possibilities of developing an abstract theory of formal semantics. Application aspects are: 1) development, research and formalization of mathematical models for problems of other disciplines, 2) development and implementation of algorithms, 3) detection of links between seemingly unrelated domains through related formalizations. Interdisciplinary and international collaboration is planned.]]></summary_en></project><project>
<id>9573</id><title_hr><![CDATA[Exploring Homelessness and Pathways to Social Inclusion: A Comparative Study of Contexts and Challenges in Swiss and Croatian Cities, Croatian Swiss Research Programme (CSRP), No. IZHRZ0_180631 / 1. ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>13277</user_id><user_firstLast_name>Lynette Šikić Mićanović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-8517</code><acronim><![CDATA[]]></acronim><duration>01.10.2020 - 12.11.2025</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Etnologija i antropologija, </scie_field_hr><scie_field_en>Ethnology and anthropology, </scie_field_en><institution_hr><![CDATA[Institut društvenih znanosti Ivo Pilar]]></institution_hr><institution_en><![CDATA[Institute of Social Sciences Ivo Pilar in Zagreb]]></institution_en><team_members_id>856149</team_members_id><team_members_names><![CDATA[ Doktorand: Paula Greiner ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>9574</id><title_hr><![CDATA[Nove primjene 14 MeV neutrona]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1377</user_id><user_firstLast_name>Davorin Sudac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-3751</code><acronim><![CDATA[NeA]]></acronim><duration>01.12.2020 - 31.05.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>861467</team_members_id><team_members_names><![CDATA[ Doktorand: Josip Batur ]]></team_members_names><keywords_hr><![CDATA[neutroni,istraživanje nafte, metan hidrat, rijetke zemlje, standardni materijali, metode detekcije, nove analitičke metode]]></keywords_hr><keywords_en><![CDATA[neutrons, oil logging, methane hydrate, rare earth elements, standard materials, method of detection, new analytical methods]]></keywords_en><summary_hr><![CDATA[Razvit će se metoda primjene brzih pulsiranih neutrona i/ili metode pridružene alfa čestice u istraživanju nalazišta metan hidrata (MH) i elemenata rijetkih zemalja (ERZ). Nalazišta metan hidrata mogu poslužiti kao izvor energije jednako značajan kao i postojeći fosilni izvori energije. Razvit će se metoda pasivnog određivanja koncentracija ERZa pomoću radioaktivnog izotopa 176Lu. Razviti će se kalibracijski postupak za neutronske senzore koji mjere C/O, N/C omjere kao i omjere drugih elemenata od interesa (Al, Si, P, S, Cl, Fe, …). Kako koncentracije elemenata mjerena neutronskim senzorom ovise o okruženju, kalibracijski postupak će se ponoviti za različita tipična okruženja (mineralna, metalna ili organska matrica). Specijalna pažnja posvetiti će se razvoju nove instrumentacije u istraživanju naftnih bušotina (Carbon-to Oxygen oil logging). Cilj istraživanja je razviti metodologiju mjerenja varijacija omjera koncentracija kemijskih elemenata, naročito C/O omjera na maloj skali, što može značajno povećati efikasnost eksploatacije već postojećih naftnih bušotina. Ciljevi istraživanja su:-	Razvoj metoda za ispitivanje podvodnih MH, ERZ i drugih mineralnih nalazišta od interesa-	Razvoj naprednih nuklearnih senzora, naročito za monitoriranje sirove nafte, precizno mjerenja C/O omjera u naftnim bušotinama, uz pomoć najnovijih tehnologija-	Razvoj ‘’ Quality Assurance/Quality Control QA/QC’’ procedure za neutronske sisteme-	Izobrazba mladih istraživača]]></summary_hr><summary_en><![CDATA[Applications of nuclear analytical methods in exploring and monitoring of methane hydrate (MH) and rare earth elements (REE) deposits will be developed by using the pulsed fast neutrons and/or associated alpha particle imaging (API) technique. Methane hydrate deposits can serve as an energy source favorably to the all of the world remaining conventional hydrocarbon sources. A method of passive determination of the REE concentration using a radioactive isotope 176Lu will be developed. The calibration procedures for neutron interrogation systems will be developed for measuring the C/O, N/C ratios and ratios of the other elements of interest (Al, Si, P, S, Cl, Fe, …). Since the concentration values measured by neutron interrogation systems depend on surrounding material too, the calibration procedure will be repeated for different types of surrounding (mineral, metal or organic matrix). Special interest shall be assigned to development of a new instrumentation in Carbon-to-Oxygen (C/O) oil logging. The aim of this research would be the development of a methodology for the measurement of small scale variations in chemical elements concentrations, in particular of C/O ratio, which could significantly increase the exploitation of the existing oil wells.  The specific research objectives are: -	Development of methods for investigation of underwater MH, REE and other mineral deposits of interest;-	Development of advanced nuclear sensors, in particular for crude oil monitoring and for precise C/O logging for very thin layers, coupled with cutting-edge developments in neutron generators, detector technologies, “smart” collimators and analysis techniques.-	Development of the Quality Assurance/Quality Control QA/QC procedures for neutron interrogation systems; -	Hands on training of young researchers.]]></summary_en></project><project>
<id>9575</id><title_hr><![CDATA[Utjecaj različitih vinifikacijskih tehnologija na kvalitativna svojstva vina od autohtonih hrvatskih sorti: uloga vina u ljudskoj prehrani]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6511</user_id><user_firstLast_name>Sanja Radeka</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-1901</code><acronim><![CDATA[VINUM SANUM]]></acronim><duration>22.07.2020 - 21.07.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Institut za poljoprivredu i turizam]]></institution_hr><institution_en><![CDATA[Institute of Agriculture and Tourism in Poreč]]></institution_en><team_members_id>855671</team_members_id><team_members_names><![CDATA[ Doktorand: Ena Bestulić ]]></team_members_names><keywords_hr><![CDATA[vino, vinifikacijske tehnologije, polifenoli, antioksidanti, ljudsko zdravlje]]></keywords_hr><keywords_en><![CDATA[wine, vinification technology, polyphenols, antioxidants, human health]]></keywords_en><summary_hr><![CDATA[Postoji veliki nedostatak objektivnih spoznaja o utjecaju primjene različitih vinifikacijskih tehnologija na kvalitativna svojstva vina od hrvatskih autohtonih bijelih  crnih sorti vinove loze, te njihove uloge u ljudskoj prehrani. Cilj ovog projekta je utvrditi razlike između kvalitativnih svojstava mladih (svježih) i zrelih (odležalih) vina gospodarski najvažnijih hrvatskih autohtonih bijelih i crnih sorti vinove loze (Malvazija istarska, Teran, Pošip i Plavac mali), proizvedenih različitim tehnologijama vinifikacije (kao što su standardna „brza prerada“ bez maceracije masulja, sa dodatkom i bez dodatka enoloških tanina, kratkotrajna, predfermentativna (crio) maceracija, dugotrajna, postfermentativna maceracija masulja i odležavanje vina u drvenim bačvama), te utjecaj njihove umjerene, kontrolirane konzumacije na psiho-fizičko zdravlje skupina ispitanika uključenih u istraživanje. Proizvedena vina biti će podvrgnuta detaljnoj analizi osnovnog fizikalno-kemijskog sastava, sastava hlapljivih armatskih spojeva, fenolnih spojeva, antioksidacijskog potencijala i nutritivnih svojstva, te će vina biti i senzorno ocjenjena. Posebna pozornost posvetit će se istraživanju spojeva zaslužnih za biološku aktivnost vina i njegovu pozitivnu ulogu u ljudskoj prehrani. Skupine ispitanika uklučene u istraživanje biti će podvrgnute kontroliranoj umjerenoj konzumaciji bijelih i crnih vina, proizvedenih specifičnim tehnologijama, u trajanju od 1-3 mjeseca, te će im se redovito kontrolirati zdravstveni parametri (tlak, šećer, kolesterol LDL, HDL, hormoni „sreće“ itd.). Također ispitanici će biti anketirani, prema unaprijed razrađenim anketnim upitnicima, o razini raspoloženja prije i nakon umjerene konzumacije vina. ]]></summary_hr><summary_en><![CDATA[There is a great lack of objective knowledge of the influence of the use of different vinification technologies on the qualitative properties of wines produced from Croatian autochthonous white grape varieties of vines and their role in human nutrition. The aim of this project is to determine the differences between the qualitative characteristics of young (fresh) and mature (aged) wines of the most important Croatian autochthonous white and black grape varieties (Malvazija istarska, Teran, Pošip and Plavac mali) produced by various vinification technologies (such as standard &#39;&#39;rapid processing&#39;&#39; without maceration of the grape mash, with addition and without the addition of oenological tannins, short-term pre-fermentation (cryo) maceration, long-lasting, post fermentative maceration and maturation of wine in wooden barrels), and the influence of moderate, controlled consumption of wine on the psychophysical health of surveyed groups. Produced wines will be subjected to a detailed analysis of the basic physical-chemical composition, volatile compounds, phenolic compounds, antioxidant potential and nutritional properties, and the wines will be sensoricaly evaluated. Particular attention will be paid to the research of compounds responsible for the bioactivity of wine and its positive role in human diet. The groups of participants surveyed will be subjected to controlled moderate consumption of white and black wines produced by specific technologies for 1-3 months and human health parameters will be regularly monitored (blood pressure, sugar, LDL cholesterol, HDL, &#39;&#39;happiness hormones&#39;&#39;, etc.). Also, participants will be interviewed, according to pre-elaborated questionnaires, about the psychological state before and after moderate consumption of wine.]]></summary_en></project><project>
<id>9581</id><title_hr><![CDATA[Unravelling reciprocal regulation of the  immune and endocrine systems]]></title_hr><title_en><![CDATA[]]></title_en><user_id>19051</user_id><user_firstLast_name>Felix Wensveen</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-3348</code><acronim><![CDATA[]]></acronim><duration>15.09.2020 - 15.09.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Medicine]]></institution_en><team_members_id>29106</team_members_id><team_members_names><![CDATA[ Doktorand: Dora Gašparini ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>9585</id><title_hr><![CDATA[Osiguranje električne energije u slučaju klimatskih ekstrema i prirodnih katastrofa]]></title_hr><title_en><![CDATA[]]></title_en><user_id>20175</user_id><user_firstLast_name>Ankica Kovač</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-5901</code><acronim><![CDATA[]]></acronim><duration>01.10.2020 - 30.09.2024</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, </scie_field_hr><scie_field_en>Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>856290</team_members_id><team_members_names><![CDATA[ Doktorand: Doria Marciuš ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>9588</id><title_hr><![CDATA[Modeliranje i praćenje iskustvene kvalitete imerzivnih višemedijskih usluga u 5G mrežama]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3964</user_id><user_firstLast_name>Lea Skorin-Kapov</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-3779</code><acronim><![CDATA[Q-MERSIVE]]></acronim><duration>01.10.2020 - 01.10.2023</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>25539</team_members_id><team_members_names><![CDATA[ Doktorand: Sara Vlahović ]]></team_members_names><keywords_hr><![CDATA[modeliranje i praćenje iskustvene kvalitete, virtualna i proširena stvarnost, mobilne videokomunikacijske usluge, 5G, strojno učenje]]></keywords_hr><keywords_en><![CDATA[modeling and monitoring QoE, virtual and augmented reality, mobile videocommunication services, 5G, machine learning]]></keywords_en><summary_hr><![CDATA[Ubrzan razvoj u području telekomunikacija i mreža, temeljen na migraciji prema arhitekturama pete generacije (5G), utire put novim mogućnostima pružanja usluga. Predviđa se ostvarivanje niza novih slučajeva uporabe višemedijskih usluga s visokim zahtjevima na kašnjenje, pouzdanost i širinu pojasa, koji će postati sastavni dio svakodnevnog života ljudi. Primjeri uključuju napredne imerzivne aplikacije poput virtualne i proširene stvarnosti (engl. Virtual/Augmented Reality, VR/AR), igranja te strujanja videa ultra-visoke razlučivosti i s 360 stupnjeva. Skup aplikacija koje koriste VR/AR tehnologije zasigurno će se proširiti, te će uz rano usvojene primjene kao što je igranje uključiti i niz aplikacija za poboljšavanje društvenih iskustava, primjene u zdravstvu i obrazovanju ili u profesionalnim i industrijskim slučajevima. Uzevši u obzir kompleksnost takvih usluga, dostupnost novih uređaja, te nove domene primjene, istraživačka zajednica je suočena s izazovima istraživanja novih metodologija, modela i metrika koje bi omogućile razumijevanje i mjerenje iskustva krajnjeg korisnika. Istraživanje iskustvene kvalitete (engl. Quality of Experience, QoE) je stoga tijekom proteklih godina postalo istaknuto pitanje kojim se bave mrežni operatori i davatelji usluga. Adresiranje navedenih istraživačkih izazova inherentno zahtjeva multidisciplinaran pristup. Projekt Q-MERSIVE stoga u istraživačkom timu kombinira komplementarne ekspertize iz područja inženjerstva i mreža, dizajna sučelja/sustava i psihologije kako bi se ostvarili sljedeći ciljevi: 1) razvoj novih modela iskustvene kvalitete za imerzivne umrežene AR/VR 5G aplikacije i mobilne višekorisničke videokomunikacijske usluge, te 2) razvoj novih rješenja za praćenje iskustvene kvalitete i različitih pokazatelja performansi iz perspektive mreže, koristeći kao temelj razvijene modele iskustvene kvalitete. Rješenja će se temeljiti na tehnikama strojnog učenja, ali i analitičkim pristupima, ovisno o primjenjivosti.]]></summary_hr><summary_en><![CDATA[Rapid developments in the telecommunications and networking communities, centered around the migration towards 5G architectures, are paving the way towards new service delivery opportunities. A wide range of advanced applications are expected to become an integral part of people’s everyday lives, with examples including immersive applications, such as virtual reality (VR), augmented reality (AR), gaming, and ultra-high-definition/360-degree video streaming, requiring unprecedented high access speeds, fast rendering, and in certain cases ultra-low latency. Applications leveraging VR/AR technologies will likely go beyond early adopters such as gaming, to enhancing social experiences, healthcare, education, or being used in professional and industrial use cases. Given the complexity of such services, the availability of new hardware on the market, and new application domains, the research community is faced with the challenges of exploring new methodologies, models, and metrics to measure the end user experience. Quality of Experience (QoE) research has thus received much attention over the past years and has become a prominent issue addressed by network, service, and content providers. Addressing these research challenges inherently calls for a multidisciplinary approach. The Q-MERSIVE project combines complementary expertise from engineering and networking, interface/system design, and psychology, to achieve the following overall goals: 1) to propose novel QoE models for immersive 5G-enabled networked AR/VR applications and mobile multi-party conversational video communication services, that map underlying system, context, and user factors to QoE as perceived at the user level, and 2) to propose novel solutions for in-network monitoring of QoE and various Key Performance Indicators, using as a basis developed QoE models. Solutions will rely on machine learning-based techniques, as well as analytical approaches as applicable.]]></summary_en></project><project>
<id>9590</id><title_hr><![CDATA[Elektromagnetske strukture za nadolazeće generacije  komunikacijskih sustava ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>18913</user_id><user_firstLast_name>Silvio Hrabar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-8918</code><acronim><![CDATA[ELESECOM]]></acronim><duration>01.10.2021 - 01.04.2026</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>865115</team_members_id><team_members_names><![CDATA[ Doktorand: Dominik Žanić ]]></team_members_names><keywords_hr><![CDATA[elektromagnetizam, metamaterijali, antene, bežični senzori, nefosterovske mreže]]></keywords_hr><keywords_en><![CDATA[electromagnetics, metamaterials, antennas, wireless sensor, non-Foster network]]></keywords_en><summary_hr><![CDATA[Jedan od glavnih zahtjeva i pokazatelja kvalitete naprednih bežičnih komunikacijskih sustava je mogućnost komuniciranja s velikim brojem korisnika i uređaja koristeći velike brzine prijenosa. Stoga je izgradnja odgovarajućih antena i pripadajućeg sklopovlja  za upravljanje  tokom elektromagnetske energije svakako veliki inženjerski izazov. Takvi antenski sustavi uključuju svojstva širokopojasnog rada, višestruku funkcionalnost, upravljanje različiitm snopovima i / ili višestruki višestruki izlazno-ulazni  način rada (MIMO), kontrolu polarizacije, prostorno i frekvencijsko filtriranje, aktivno i pasivno suzbijanje smetnji, čak uključujući radiofrekvencijsku obradu signala unutar sklopovlja antena. Trenutačno nije jasno koja bi tehnologija bila najbolji izbor za ispunjavanje svih ovih zahtjeva. Elektromagnetska skupina na Sveučilištu u Zagrebu iskoristit će svoje nedavne  rezultate istraživanja u metamaterijalima korištenjem tri komplementarna pristupa za uporabu u antenama i pripadajućim elektromagnetnim strukturama za buduće komunikacijske sustave. Prvi pristup temelji se na periodičnim strukturama za vođenje elektromagnetske energije u kombinaciji s lećama i metapovršinama. Ovaj pristup će dovesti do milimetarskih antenskih nizova s visokom učinkovitošću. Drugi pristup poboljšat će svojstva sustava ugradnjom naprednih aktivnih metamaterijalnih struktura kao što su radiofrekvencijski linearni i nelinearni podsustavi s negativnom impedancijom. Ovi aktivni podsustavi će omogućiti upravljanje glavnom zrakom i kontrolu polarizacije, zajedno s pretvorbom prema gore i prema dolje, te svojstvom samo-osciliranja. Treći se pristup bavi novom bežičnom senzorskom tehnologijom u milimetarskom režimu. U završnom dijelu projekta pokušat će se kombinirati znanje postignuto korištenjem sva tri pristupa integracijom u višenamjenski elektromagnetski sustav, prikladan za uporabu u novim sustavima komunikacija, senzora i pozicioniranja.]]></summary_hr><summary_en><![CDATA[One of the main requirements and quality indicators of the advanced wireless communications systems is the ability to communicate with a large number of users and devices with high-speed connections. Therefore,  construction of  the appropriate antennas and associated hardware for steering the flow of electromagnetic energy in emerging communication systems is certainly a big engineering challenge. The required properties of these antenna systems will include broad frequency-band operation, multi-functionality, beam steering and/or multiple-input multiple-output (MIMO) mode of operation, polarization control, spatial and frequency filtering, active and passive interference suppression including radiofrequency signal processing.  At the moment, it is not clear which technology would be the best choice for meeting these requirements. The electromagnetic group at University of Zagreb will leverage their recent advances in metamaterials by investigation of three complementary approaches for use in the antennas and associated electromagnetic structures for future emerging communication systems. The first approach will be based on the guiding periodic structures combined with lenses and metasurfaces. This approach will lead to millimeter antenna arrays with high efficiency. The second approach will enhance the system properties by incorporation of advanced active metamaterial-inspired structures such as negative-impedance linear and non-linear processing subsystems. These active subsystems will add tunability, steering and polarization control, together with up-conversion, down-conversion and self-oscillating properties.  The third approach will deal with novel wireless sensor technology in millimeter regime.  In the final part of the project, it will be attempted to combine knowledge achieved using all three approaches towards integration into a multi-functional electromagnetic system, convenient for use in emerging communications, sensing and positioning systems.]]></summary_en></project><project>
<id>9593</id><title_hr><![CDATA[Utvrđivanje pojavnosti, uzroka i štetnih učinaka oksidativnog stresa izazvanog uporabom fiksnih ortodontskih naprava ]]></title_hr><title_en><![CDATA[»Investigation of oxidative stress occurrence, causes and harmful effects induced by the use of fixed orthodontic appliances«]]></title_en><user_id>5198</user_id><user_firstLast_name>Gordana Čanadi Jurešić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IPS</proposal_type><proposal_call>2020-01</proposal_call><code>IPS-2020-01-7418</code><acronim><![CDATA[IPS-2020-01-7418 ]]></acronim><duration>02.10.2020 - 01.10.2023</duration><status>Prekinut</status><financ_value>75.287,01 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Dentalna medicina, Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Dental medicine, Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Medicine]]></institution_en><team_members_id>77, 99, 29088, 864904, 865544, </team_members_id><team_members_names><![CDATA[Stjepan Špalj, Višnja Katić, Lara Dežulović, Zana Jusufi Osmani, Luqman Khan, ]]></team_members_names><keywords_hr><![CDATA[oksidativni stres, fiksne ortodontske naprave, kvasac, metalni ioni, mitohondriji]]></keywords_hr><keywords_en><![CDATA[oxidative stress, fixed oxidative appliances, yeast, metal ions, mitochondria]]></keywords_en><summary_hr><![CDATA[U usnoj se šupljini djelovanjem sline promjenjivog pH, žvačnih i ortodontskih sila, te mikroorganizama utječe na strukturnu i kemijsku stabilnost dentalnih naprava čiji se metalni elementi (bravice, cjevčice, prstenovi i žice) izrađuju od plemenitoga čelika te legura Cr, Ni, Ti, Fe i Mo. Ti su metalni elementi u stalnom međudjelovanju s oralnom sluznicom te se vodom iz sline ispiru ioni iz metalnih žica, osobito iona Ni, Fe i Cr. Kvasac Saccharomyces cerevisiae posjeduje efikasne mehanizme za  uklanjanje toksičnosti raznovrsnih metala i može preživjeti različite stresne uvjete što ga čini idealnim modelnim organizmom za proučavanje mehanizama odgovora na stres izazvan metalima. Izlaganje kvasca S. cerevisiae ionima metala (kao što su Fe i Ni) dovodi do stvaranja slobodnih radikala i izazivanja oksidativnog stresa.  Mitohondriji su središnja organela za proizvodnju reaktivnih kisikovih vrsta i brojnih drugih štetnih reaktivnih spojeva i svaka će se promjena na mitohondrijima reflektirati na rad cjelokupne stanice. Budući da su mitohondriji važni u mnogim staničnim procesima i u razvoju mnogih bolesti, istraživanja na nivou proteina (i mitohondrijskih i staničnih), kao ključnih molekula u tim procesima, je neprocjenjiva.U ovom će se istraživanju pratiti (toksični) utjecaj iona metala iz dentalnih naprava (prvenstveno žica i bravica) koje se tijekom terapije ispiru iz njih, na kvasac Saccharomyces cerevisiae. Kvasac će se tretirati bilo „ekstraktom“ žica ili metalnim ionima (Ni2+ ili Ti4+)  u koncentracijama koje su utvrđene da se otpuštaju iz žica. Očekuje se učinak tih iona na nivou cijelih stanica (što će se utvrditi praćenjem metaboličke aktivnosti, promjenama oksidativnog statusa, funkcionalnosti mitohondrija preko metaboličke izmjene: glikoliza/mitohondrijska respiracija) te na nivou mitohondrija, promjenom u proteinskom izričaju (i u broju identificiranih, ali i u broju proteina s povećanim/smanjenim izričajem).]]></summary_hr><summary_en><![CDATA[In the mouth, with the action of saliva of variable pH, chewing and orthodontic forces and microorganisms, the structural and chemical stability of dental appliances are affected.  Metal elements of these devices (brackets, tubes, rings and wires) are made of stainless steel and alloys of Cr, Ni, Ti, Fe and Mo. These metallic elements are in the constant interaction with the oral mucosa, and with the action of saliva the ions of metal wires (especially Ni2+, Fe2+ and Cr3+), are flushed out. The yeast, Saccharomyces cerevisiae, possesses efficient mechanisms for eliminating the toxicity of various metals and can survive broad stress scenarios.  This promotes S. cerevisae to an ideal model organism for studying the stress response mechanisms caused by metals. Exposure of S. cerevisiae to metal ions (such as Fe and Ni) leads to the formation of free radicals and induce oxidative stress. Mitochondria are the central organelles for the production of ROS and many different harmful reactive compounds, and any change at the mitochondria level will be reflected to the entire cell. Mitochondria are important in many cellular processes and in the development of many diseases, so, the research at (the mitochondrial and cellular) protein level, as key molecules in these processes, is invaluable.In this study, the (toxic) influence of metal ions leached from dental devices (primarily wires and brackets) during dental therapy, on the yeast S. cerevisiae will be monitored. Yeast will be treated with either &#39;&#39;wire extract&#39;&#39; or metal ions (Ni2+ or Ti4+) at concentrations determined to be released from the wires. The effect of these ions is expected at the whole cell level and at mitochondrial level. The effect will be determined by monitoring metabolic activity, changes in oxidative status and checking mitochondrial function (at the cellular level) while by changes in protein expression (number of identified proteins or with changed expression, at the level of mitochondria).]]></summary_en></project><project>
<id>9594</id><title_hr><![CDATA[Uloga bradikinina u ishemiji mozga i mrežnice u mišjim modelima dijabetesa]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6226</user_id><user_firstLast_name>Marina Radmilović (Dobrivojević)</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-4773</code><acronim><![CDATA[BRADISCHEMIA]]></acronim><duration>15.10.2021 - 15.08.2025</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>865161</team_members_id><team_members_names><![CDATA[ Doktorand: Marta Pongrac ]]></team_members_names><keywords_hr><![CDATA[dijabetes, ishemija, bradikinin, moždani udar, dijabetička retinopatija]]></keywords_hr><keywords_en><![CDATA[diabetes, ischemia, bradykinin, stroke, diabetic retinopathy]]></keywords_en><summary_hr><![CDATA[Dijabetes je kronična bolest koja obuhvaća metaboličke poremećaje obilježene povišenom razinom glukoze u krvi kao posljedicom nedovoljne proizvodnje inzulina, rezistencije na djelovanje inzulina ili obaju mehanizama. Trenutno pola milijarde ljudi diljem svijeta ima dijabetes. Tijekom trajanja dijabetesa, trećina oboljelih razvije ishemijski moždani udar,  trećina razvije dijabetičku retinopatiju, a obje navedene komplikacije dovode do ozbiljnog invaliditeta s neizmjernim socioekonomskim utjecajem. S patofiziološkog gledišta, i dijabetička retinopatija i moždani udar karakterizirani su ishemijom. Bradikinin je među prvim upalnim čimbenicima koji se javljaju s nastupom ishemije. Bradikinin povećava permeabilnost krvno-moždane/-žilnične barijere, inducirajući nastanak edema. Budući da aktivacija njegovih receptora pridonosi nastanku edema i oštećenju tkiva modulacijom post-ishemijskog upalnog odgovora, potraga za inhibitorima koji bi mogli smanjiti te štetne učinke postala je važan cilj. Ipak, uloga bradikininskih receptora nije jednostrana, budući da su zabilježeni i razni povoljni učinci njihove aktivacije, poput prevencije odumiranja endotelnih stanica, redukcije glutamatne neurotoksičnosti, te preživljenja i migracije glija stanica. Ova dovojaka uloga bradikininskih receptora poticaj je za naše istraživanje, kojim ćemo istražiti ulogu bradikininskog receptora tipa 2 u dvama specifičnim komplikacijama koje se razvijaju u tijeku dijabetesa: dijabetičkoj retinopatiji i moždanom udaru. Korištenjem uspostavljenih modaliteta snimanja magnetskom rezonancijom, omogućit će nam longitudinalno praćenje razvoja ishemijske moždane ozljede. Također planiramo unutar već uspostavljenog laboratorija razviti s novu platformu za multimodalno pretkliničko istraživanje bolesti mrežnice, prvu platformu takve vrste u Republici Hrvatskoj, a koja bi otvorila mogućnosti novim i sveobuhvatnijim pretkliničkim istraživanjima ekperimentalnih terapija i učinkovitijoj translaciji prema klinici.]]></summary_hr><summary_en><![CDATA[Diabetes mellitus is a chronic disease that comprises metabolic conditions characterized by elevated blood glucose levels resulting from either inadequate insulin production, resistance to insulin action, or both. Currently, half a billion people are affected by diabetes worldwide. During the course of the disease, one-third of diabetic patients develop ischemic stroke, one third develop diabetic retinopathy, both leading to severe disabilities with immense socioeconomic impact. Pathophysiologicaly, both diabetic retinopathy and stroke are characterized by ischemia. Bradykinin is one of the first inflammatory factors released during the ischemia. Bradykinin increases the blood-brain/retinal barrier permeability, inducing edema formation. Since activation of bradykinin receptors contributes to brain edema and tissue damage modulating the post-ischemic inflammatory response, the search for inhibitors that could diminish these detrimental effects has become an important issue. However, the role of bradykinin receptors is not so unambiguous, since different beneficial effects of their activation were also shown in preventing endothelial cell death, lowering glutamate neurotoxicity, and enhancing glial cell survival and migration. This ambiguous role of the bradykinin receptors is what prompts our research, which will be achieved through the research of the role of bradykinin in two distinct complications that occur in the course of diabetes: diabetic retinopathy and ischemic stroke. By using magnetic resonance imaging modalities, we aim to perform a longitudinal study of the progression of cerebral ischemia. Within the established imaging facility, we plan to set up a completely new platform for multimodal preclinical research of retinal diseases, which would be the first platform of its kind in Croatia and would open up possibilities for novel more comprehensive preclinical evaluation of experimental therapies with a more efficient preclinical to clinical translation.]]></summary_en></project><project>
<id>9595</id><title_hr><![CDATA[AeRoTwin - Twinning coordination action for spreading excellence in Aerial Robotics ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5244</user_id><user_firstLast_name>Stjepan Bogdan</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-9403</code><acronim><![CDATA[]]></acronim><duration>01.10.2020 - 30.09.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Temeljne tehničke znanosti, </scie_field_hr><scie_field_en>Basic engineering sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>862765</team_members_id><team_members_names><![CDATA[ Doktorand: Marko Križmančić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>9596</id><title_hr><![CDATA[Biologija citomegalovirusne infekcije u mozgu tijekom razvoja i u latenciji]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4834</user_id><user_firstLast_name>Ilija Brizić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-5362</code><acronim><![CDATA[CMVbrain]]></acronim><duration>01.09.2020 - 30.04.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Medicine]]></institution_en><team_members_id>861498</team_members_id><team_members_names><![CDATA[ Doktorand: Fran Krstanović ]]></team_members_names><keywords_hr><![CDATA[citomegalovirus, kongenitalna infekcija, tropizam, stanice mozga, imunološki odgovor, gH/gL, astrociti, mikroglija, neuroni, MCMV]]></keywords_hr><keywords_en><![CDATA[cytomegalovirus, congenital infection, tropism, brain cells, immune response, gH/gL, astrocytes, microglia, neurons, MCMV]]></keywords_en><summary_hr><![CDATA[Prirođena CMV infekcija je glavni uzročnik transplacentarno prenosivih prirođenih infekcija koja može uzrokovati široki spektar strukturnih i funkcionalnih oštećenja i trajne neurološke posljedice. Infekcija mozga tijekom prirođene infekcije CMV-om ima veliki značaj, međutim, stanična mjesta infekcije tijekom akutne faze infekcije i latencije su još uvijek nejasna. In vitro CMV može inficirati do određene razine većinu staničnih vrsta mozga, međutim nije jasno vrijedi li to in vivo, i koja je priroda infekcije (abortivna ili produktivna) je slabo istraženo. Nadalje, nije poznato u kojim stanicama se nalazi latentni CMV i u kojim stanicama CMV reaktivira u mozgu. Mi ćemo se usredotočiti na tri glavne vrste stanice u mozgu: neurone, astrocite i mikrogliju. Kako bi odredili stanične vrste koje su inficirane koristit ćemo reporterski virus MCMV-GFP_Cre koji će nam omogućiti da odredimo u kojim stanicama se nalazi virus tijekom akutne faze infekcije i u latenciji. Nadalje, odredit ćemo u kojim stanicama MCMV reaktivira nakon deplecije T limfocita u mozgu i koje stanice proizvode infektivni virus u mozgu. Također, odredit ćemo transkriptom pojedinačnih stanica u mozgu, kako bi odredili kako infekcija u mozgu mijenja stanice. Kako bi odredili koji gH/gL kompleksi posreduju infekciju stanica u mozgu generirat ćemo nove rekombinantne viruse koji imaju mutacije u genima koji kodiraju za proteine MCK-2 i gO, MCMV proteine koji formiraju gH/gL komplekse. Ova istraživanja će odgovoriti na važna pitanja o infekciji stanica u mozgu, mjestima latencije virusa i izvoru (reaktivirajućeg) virusa u mozgu, kao i koji virusni proteini su važni za infekciju stanica u mozgu. Razumijevanje ovih mehanizama je potrebno kako bi spriječila infekcija i patologija u središnjem živčanom sustavu. Rezultati ovog projekta će pridonijeti boljem razumijevanju patogeneze prirođene CMV infekcije u mozgu, te će otvoriti nove smjerove istraživanje CMV infekcije, kao i terapije.]]></summary_hr><summary_en><![CDATA[Congenital CMV infection is a major cause of trans-placentally transmitted congenital infections and may cause a wide range of structural and functional disabilities and permanent neurological sequelae. Infection of the brain during congenital CMV infection is of great interest, however, the cellular sites of infection during acute and latent infection are still poorly characterized. The majority of brain cell types are fully or partially permissive for CMV in vitro, but it remains unclear which cell types are productively infected in vivo and support viral replication and dissemination within the brain. Furthermore, cells harboring latent CMV and cells reactivating CMV in brain are unknown. We will focus on major cell types in the brain: neurons, astrocytes and microglia. To determine the cellular sites of infection we are going to use a reporter virus (MCMV-GFP_Cre) which will enable us to identify cells harboring virus during acute and latent infection. Furthermore, we will determine which cells reactivate MCMV upon depletion of T cells in brain and cellular source of infectious virus in brain. Finally, we will perform single cell sequencing of uninfected and latently infected cells in the brain, to determine how latent infection remodels the brain cells. To determine which gH/gL complexes mediate infection of brain cells we will generate novel recombinant viruses harboring mutations in MCK-2 and gO, MCMV proteins forming complexes with gH/gL proteins. These studies will answer the longstanding questions regarding the infection, sites of latency and source of (reactivating) virus in brain. In addition, we will determine requirement for viral proteins for infection of brain cells. Understanding these mechanisms is needed to prevent CMV infection and pathology in central nervous system. Results of this project will contribute to better understanding of congenital CMV pathogenesis in brain, and will open new avenues of CMV research and therapy.]]></summary_en></project><project>
<id>9599</id><title_hr><![CDATA[Nova generacija poluvodičkih elemenata i integriranih sklopova za eru Interneta stvari]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6955</user_id><user_firstLast_name>Tomislav Suligoj</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-7695</code><acronim><![CDATA[NexGenSemi]]></acronim><duration>01.10.2020 - 30.09.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>861727</team_members_id><team_members_names><![CDATA[ Doktorand: Filip Bogdanović ]]></team_members_names><keywords_hr><![CDATA[Internet stvari, bipolarni tranzistor s horizontalnim tokom struje, pouzdanost, poluvodički fotodetektor, galij-nitrid, simulacije poluvodiča]]></keywords_hr><keywords_en><![CDATA[Internet of Things, Horizontal Current Bipolar Transistor, reliability, semiconductor photodetectors, gallium-nitride, semiconductor simulations]]></keywords_en><summary_hr><![CDATA[Cilj ovoga projekta je istražiti nove poluvodičke elemente i sklopove pogodne za primjenu na različitim nivoima Interneta stvari (eng. Internet-of-Things – IoT), od senzorskih čvorova, preo komunikacijskih sklopova, do elemenata za mrežnu infrastrukturu. Elektronički elementi i sklopovi za tako različite dijelove IoT sustava bit će istraženi u 3 područja: (i) Pouzdanost i pojačala snage u tehnologiji tranzistora sa horizontalnim tokom struje (HCBT), (ii) Projektiranje, karakterizacija i modeliranje blisko infracrvenih, vidljivih i UV fotodetektorskih prednjih krajeva, i (iii) Modeliranje i primjene GaN HEMT-ova.Doherty pojačalo snage i pojačalo za praćenje envelope kao primjeri visokoefikasnih RF pojačala snage za modulacije s velikim omjerom maksimalne i prosječne snage projektirat će se u HCBT tehnologiji koja ima nisku cijenu proizvodnje, a vrlo visoke performanse. To će biti prva RF pojačala snage s HCBT-ovima čime će se pokazati prikladnost tehnologije za sklopove s velikim signalom. Dodatno će se proučavati i pouzdanost HCBT elemenata s obzirom na pobudu jakim RF signalom i zračenjima.Uz proširenje našeg jedinstvenog električkog modela PureB materijala na siliciju za UV detektore, predloženi projekt bit će usmjeren i na visoko-osjetljive, blisko infra-crvene detektore implementirane u čistom galiju i PureB (PureGaB) na germaniju (Ge) nanesenom na Si supstrat, kao i na projektiranje detektora jednog fotona i njegove sklopove za potiskivanje proboja.Modeliranje GaN HEMT-a bit će istraženo pomoću fizikalno-baziranih modela. Transport elektrona u kanalu HEMT-a bit će modeliran samo-konzistentnim simulacijama mehanizama raspršenja, sa korijenima u kvantnoj mehanici, koji će uzeti u obzir kvantno ograničenje, strukturu energetskih pojaseva i sve relevantne mehanizme raspršenja.S obzirom na dosadašnja postignuća naše grupe, mogu se očekivati publikacije u vodećim znanstvenim časopisima i konferencijama kao i prijave patenata.]]></summary_hr><summary_en><![CDATA[The aim of this project is to conduct a research on novel semiconductor devices and circuits suitable for the Internet-of-Things (IoT) applications at various levels, to cover sensor nodes, communication circuits and devices for network infrastructure. Electron devices and circuits for such different parts of IoT systems will be researched in 3 areas: (i) Device reliability and power amplifiers (PAs) in Horizontal Current Bipolar Transistor (HCBT) technology, (ii) Design, characterization and modeling of near-infrared, visible and UV photodetector front-ends, and (iii) Modeling and applications of GaN HEMTs.The Doherty and Envelope tracking PAs with their high-efficiencies for high peak-to-average-power-ratio modulations will be designed in low-cost, high-performance HCBT technology. These will be the first RF power amplifiers with HCBTs demonstrating the suitability of HCBT technology for large-signal RF applications. Additionally, the reliability of HCBT devices will be tested against high RF power stress and radiation stresses.Besides extending our unique electrical model of PureB-on-Silicon material for UV detectors, the focus in the proposed project will also be on high-sensitivity, near-infra-red (NIR) detectors implemented in pure gallium and PureB (PureGaB) on germanium (Ge) grown on Si substrate together with the design of single photon avalanche detectors (SPADs) and their quenching circuits.The modeling of GaN high electron mobility transistor (HEMT) will be researched by physics-based models. The transport of electrons in HEMT channel will be assessed by self-consistent carrier scattering simulations, rooted in quantum mechanics that will take into account quantum confinement, bandstructure effects and all relevant scattering mechanisms.Based on a track record of the group, the publications in the top journals and conferences in the field and patent applications can be expected in this project.]]></summary_en></project><project>
<id>9601</id><title_hr><![CDATA[Novi koncept praćenja terena koji se osniva na Orlu, CLC+]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4898</user_id><user_firstLast_name>Tarzan Legović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-9841</code><acronim><![CDATA[]]></acronim><duration>01.11.2020 - 30.04.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[OIKON d.o.o.-Institut za primijenjenu ekologiju, Zagreb]]></institution_hr><institution_en><![CDATA[OIKON Ltd-Institute for Applied Ecology, Zagreb]]></institution_en><team_members_id>858330</team_members_id><team_members_names><![CDATA[ Doktorand: Nela Jantol ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>9604</id><title_hr><![CDATA[Dizajn katalitički aktivnih peptida i peptidnih nanostruktura]]></title_hr><title_en><![CDATA[]]></title_en><user_id>2658</user_id><user_firstLast_name>Goran Mauša</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-4659</code><acronim><![CDATA[DeShPet]]></acronim><duration>08.10.2020 - 31.12.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Tehnički fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Engineering]]></institution_en><team_members_id>856300</team_members_id><team_members_names><![CDATA[ Doktorand: Erik Otović ]]></team_members_names><keywords_hr><![CDATA[Peptidi, samoorganizacija, kataliza, strojno učenje, modeli predviđanja, AFM, meki materijali]]></keywords_hr><keywords_en><![CDATA[Peptides, self-assembly, catalysis, machine learning, prediction models, AFM, soft materials]]></keywords_en><summary_hr><![CDATA[Područje umjetnih enzima u posljednje je vrijeme privuklo veliku pozornost istraživačke zajednice te su predloženi razni pristupi oponašanja bioloških katalizatora. Jedan od pristupa je stvaranje minimalističkih katalizatora na osnovi peptida i njihovih samoorganizirajućih nanostruktura. Peptidi su od velikog interesa u biomedicini zbog svoje inherentne bio-kompatibilnosti i biorazgradivosti, niske toksičnosti metabolita i zbog činjenice da su gradivni blokovi života. Poznato je da se kratki peptidi mogu samostalno organizirati u nano-strukture s različitim fizičkim i strukturnim karakteristikama, što često rezultira novim svojstvima i funkcijama koje nisu vidljive u njihovim monomerima, tj. sekvencama. Jedna takva funkcija je katalitička aktivnost. S druge strane, malo je poznato o principima koji reguliraju katalitičku aktivnost kratkih peptida, ali iz prethodnih istraživanja znamo da su i aminokiseline i njihov redoslijed unutar sekvence važni. U ovom projektu namjeravamo povezati strojno učenje i eksperimentalnu validaciju kako bi provedbu budućih eksperimenata učinili ciljanom, a time učinkovitijom i ekonomičnijom. U tu svrhu nastojati ćemo otkriti obrasce u postojećim podacima te ubrzati otkrivanje novih katalitičkih peptida kroz relativno mali broj eksperimenata. Sveobuhvatni cilj ovog projekta je odrediti možemo li uporabom strojnog učenja učinkovito predviđati katalitičku aktivnost kratkih peptida te otkriti ključne značajke koje upravljaju ovim procesom. U konačnici, želimo razumjeti kako određena peptidna sekvenca postiže katalitičku aktivnost te na koji se način željena funkcija može ostvarit kroz evoluciju sekvence u složenije (samoorganizirajuće i/ili tandemske) sustave. Upotrebom metodologije predložene ovim projektom želimo dati temelje za novu generaciju dizajna peptida, čija će se strategija moći proširiti na druge domene istraživanja kemijskog prostora te na nova otkrića.]]></summary_hr><summary_en><![CDATA[Artificial enzymes have attracted tremendous interest in recent years and several approaches to mimic biological catalysts have been proposed. One approach is to create minimalistic catalysts based on peptides and their assemblies. Peptides are increasingly investigated in biomedical applications due to their inherent biocompatibility, biodegradability, low toxicity of metabolites and because they are building blocks of life. Short peptides can self-assemble into nanostructures, which often results in new emerging functions, not observable with their constituting monomers. One such function is catalytic activity. Little is known about the principles that govern the catalytic activity of short peptides at the sequence level. From previous studies it is evident that the residues that make up the sequence and the order in which they appear are important. In this project, we want to combine machine learning with experimental validation to develop a more efficient and economical approach compared to the unguided experimental evaluation. We aim to discover patterns in existing data and accelerate the discovery of new catalytic peptides within a relatively small number of experiments. The overall objective is to determine whether we could use machine learning to efficiently predict the catalytic activity of short peptides and understand what are the key features that govern this process. We aim to reveal how are peptide sequences responsible for catalysis with the scope of evolving them to more complex systems, through self-assembly or tandem peptide repeats, to reach function. In our approach we aim to encompass the entire spectrum from fundamental understanding of peptide sequences and their ability to catalyze reactions to eventual societal benefit of discovering minimalistic versions of enzymes able to be used in every day life. The successful outcome of this project will result in a strategy able to explore broad sequence and structural spaces for future discoveries.]]></summary_en></project><project>
<id>9605</id><title_hr><![CDATA[Predviđanje ishodišnih stanica  i  istraživanje mehanizama razvoja raka bazirano na statističkom modeliranju]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1188</user_id><user_firstLast_name>Rosa Karlić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-5924</code><acronim><![CDATA[PREDI-COO]]></acronim><duration>26.10.2020 - 25.04.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>858372</team_members_id><team_members_names><![CDATA[ Doktorand: Paula Štancl ]]></team_members_names><keywords_hr><![CDATA[genomika, rak, statističko modeliranje, kromatin, mutacije]]></keywords_hr><keywords_en><![CDATA[Genomics, cancer, statistical modelling, chromatin, mutations]]></keywords_en><summary_hr><![CDATA[Raspodjela epigenetskih značajki ishodišne stanice i raspodjele mutacija u stanicama raka su međusobno ovisne, a utvrđeno je da je ta međuovisnost tkivno specifičan fenomen. U našem prethodnom radu smo iskoristili ovu činjenicu za razvoj jednostavne metode na temelju koje je sa velikom sigurnošću moguće predvidjeti ishodišno tkivo u kojem je rak nastao. Cilj ovog projekta je unapređenje prethodno razvijene metode određivanja ishodišnih stanica tumora korištenjem statističkih metoda i metoda strojnog učenja. Razviti će se i testirati metoda određivanja ishodišnih stanica tumora podacima dobivenim sekvenciranjem eksoma, te će se identificirati regije u genomu i epigenetske značajke koje su najinformativnije za određivanje ishodišnih stanica tumora. Nadalje, analizirati će se modeli trenirani na individualnim pacijentima te će se utvrditi minimalan broj mutacija i minimalna točnost modela potrebna za uspješno određivanje ishodišnih stanica tumora. Konačno, istražiti ćemo dovodi li uključivanje podataka o trodimenzionalnoj organizaciji kromatina do poboljšanja točnosti predviđanja ishodišnih stanica raka. Statistička analiza provedena u sklopu ovog projekta može dovesti do novih saznanja o staničnim procesima koji povezuju modifikacije histona i nastanak mutacija u raku, pomoći u istraživanju mehanizama nastanka različitih tipova raka i točnijeg određivanja gena koji sadrže takozvane „pogonske“ (driver) mutacije te omogućiti budući napredak u dijagnozi i tretmanu malignih bolesti.]]></summary_hr><summary_en><![CDATA[The distribution of epigenetic features of the cell-of-origin and the distribution of mutations in cancer cells are mutually dependent, and it is established that this interdependence is a tissue-specific phenomenon. In our previous work, we have used this fact to develop a simple method to predict the cell-of-origin of cancer with high accuracy.The aim of this project is to improve the previously developed method of determining the cancer cell-of-origin using statistical and machine learning methods. We will develop and validate a method of cell-of-origin prediction based on exome sequencing data and identify the most informative genomic regions and epigenetic features for prediction of the cell-of-origin. Furthermore, we will analyse models trained on individual patients and determine the minimum number of mutations and minimum accuracy of the model required for successful determination of cancer cell-of-origin. Finally, we will investigate whether the addition of information on the three-dimensional chromatin organization  will improve the prediction accuracy of the original model used for cell-of-origin prediction.The statistical analysis carried out within this project can lead to new findings about the cellular processes that link histone modifications and cancer mutations, help in the investigation of the mechanisms of development of different types of cancer and determination of genes that contain so-called &#39;&#39;driver&#39;&#39; mutations, and lead to further improvements in diagnosis and treatment of malignant diseases.]]></summary_en></project><project>
<id>9608</id><title_hr><![CDATA[Konsocijacija drvenastih vrsta i poljoprivrednih kultura kao inovativni pristup u agroekosustavima]]></title_hr><title_en><![CDATA[]]></title_en><user_id>19239</user_id><user_firstLast_name>Brigita  Popović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-4994</code><acronim><![CDATA[AGROINOVA]]></acronim><duration>09.11.2020 - 19.07.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Fakultet agrobiotehničkih znanosti Osijek]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Agrobiotechnical Sciences in Osijek]]></institution_en><team_members_id>858405</team_members_id><team_members_names><![CDATA[ Doktorand: Ante Bubalo ]]></team_members_names><keywords_hr><![CDATA[konsocijacija, orah, poljoprivredni usjevi, mikroklima, biološka raznolikost, konzervacija tla]]></keywords_hr><keywords_en><![CDATA[Intercopping, walnut, agricultural crops, microclimate, biodiversity, soil conservation]]></keywords_en><summary_hr><![CDATA[Konsocijacija ili kombinacija kultura podrazumijeva uzgoj više kultura na istoj površini u isto vrijeme. Glavne prednosti konsocijacije su: bolja iskoristivost proizvodne površine, pozitivan utjecaj na plodnost tla, raznolikost proizvodnje u jednoj vegetaciji, zaštita od pojave bolesti, štetnika i korova, bolja iskoristivost hraniva i vode u tlu te povećana biološka raznolikost. U konsocijacijama koje podrazumijevaju uzgoj u nasadima oraha poželjno je odabrati nasade s cijepljenim orasima zbog činjenice da orah luči juglon koji može imati toksičan efekt na nicanje drugih biljaka. Naime, u nasadima oraha s cijepljenim stablima lučenje juglona nije tako intenzivno i djelovanje juglona u prvih 15 godina u takvim nasadima nema značajno toksičan učinak. Isto tako, preporučljivo je unošenje organske tvari jer se time potiče mikrobiološka aktivnost koja pospješuje razgradnju juglona. Drugi važan čimbenik u ovakvim konsocijacijama jest odabir poljoprivrednih kultura koje su otporne na nisku pH vrijednost jer orah eksudatima zakiseljuje tlo.Cilj projektnog prijedloga je istražiti utjecaj međuodnosa cijepljenih oraha i poljoprivrednih kultura na mikroklimu te time na bioraznolikost u tlu (mikrobiološku aktivnost u tlu te strukture zajednice nematoda), konzervaciju tla i štetne organizme poput uzročnika biljnih bolesti. Pokus će biti proveden kroz pet godina, na dva lokaliteta u dvije županije od kojih će se svaki sastojati od tri parcele – kontrolna parcela sa usijanim poljoprivrednim kulturama bez oraha, parcela s nasadom oraha gdje će između redova biti usijane poljoprivredne kulture te trajni nasad oraha bez ratarskih kultura. Na osnovu dobivenih rezultata biti će kreiran kompjuterski model za predviđanje utjecaja mikroklime na istraživane parametre u projektnom prijedlogu. Iako su takvi modeli dostupni u svijetu u Republici Hrvatskoj ovo će biti prvi model takvog tipa koji će biti primjenjiv za agroekološke uvijete u široj regiji, odnosno područje dunavskog sliva.  ]]></summary_hr><summary_en><![CDATA[Intercropping or a combination of plant species involves more species on the same parcel at the same time. The main benefits of the intercropping are: better use of the production area, positive influence on soil, diversity of production, protection against plant disease, pests and weeds, better use of nutrients and water in soil as well as increased biodiversity. In intercropping systems with walnut it is desirable to choose orchards with grafted plants since the walnut tree secretes juglone that may have a toxic effect on the germination of other plants. In the orchards of walnuts with grafted trees, the secretion of juglone is not so intense and the activity of the juglone in the first 15 years in such intercropping systems has no significant toxic effect. Also, it is advisable to introduce organic matter as it promotes microbiological activity that decompose juglone. Another important factor in such systems is the selection of plants resistant to low-pH, since the walnuts can acidify soil.The aim of the proposed project is to investigate the interaction between grafted walnuts and agricultural crops to microclimate and consequently to soil biodiversity (microbiological activity in soil and nematode community structure), soil conservation and occurrence of plant diseases.The field trial will be conducted during five years, at two locations in two Counties, each field trial will consist of three parcels - control plot of agricultural crops without walnuts, walnut orchards with intercropped agricultural crops and a permanent walnut orchard without intercropped agricultural crops. Based on the obtained results, a computer model will be created for predicting the influence of microclimate on the investigated parameters in the project proposal. Although such models are available worldwide in the Republic of Croatia, this will be the first model of such type that will be applicable for agroecological conditions in the wider region, mainly the Danube Basin area.]]></summary_en></project><project>
<id>9609</id><title_hr><![CDATA[Matične stanice usne šupljine čovjeka za liječenje ishemijske bolesti mozga]]></title_hr><title_en><![CDATA[]]></title_en><user_id>12653</user_id><user_firstLast_name>Dinko Mitrečić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-3000</code><acronim><![CDATA[ORASTEM]]></acronim><duration>01.11.2020 - 31.10.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>858356</team_members_id><team_members_names><![CDATA[ Doktorand: Paula Stančin ]]></team_members_names><keywords_hr><![CDATA[moždani udar, matične stanice, sluznica usne šupljine, regenerativna medicina, transkriptom ]]></keywords_hr><keywords_en><![CDATA[stroke, stem cells, oral mucosa, regenerative medicine, transriptome]]></keywords_en><summary_hr><![CDATA[Ishemijska ozljeda mozga je najčešći oblik moždanog udara te predstavlja jedan od najvećih medicinskih problema čovječanstva. U ovom projektu ćemo po prvi put istražiti terapijski potencijal nedavno otkrivenih ektodermalnih matičnih stanica ljudske sluznice usne šupljine (SOS) na modelu ishemije mozga miša. U preliminarnim pokusima smo pokazali da se ove stanice lako dobivaju iz sluznice usne šupljine pacijenta, a zbog svojeg ektodermalnog podrijetla daju živčane i glija stanice. Nakon dobivanja stanica u suradnji sa Stomatološkim fakultetom u Zagrebu, analizirat ćemo njihovo umnažanje, diferencijacijski potencijal i preživljenje tijekom rasta in vitro. Biljege diferencijacije ćemo analizirati RT-PCRom i imunohistokemijom u periodu od 14 dana, a rezultati dobiveni u normalnim uvjetima će se usporediti sa onima u uvjetima hipoksije. Razlike u odgovoru stanica na ishemiju će biti analizirane na razini transkriptoma koja će biti učinjena u suradnji s New York University Abu Dhabi. U idućoj grupi pokusa ćemo transplantirati SOS u mišji model moždanog udara. U dvije vremenske točke, 7 i 30 dana nakon transplantacije ćemo opisati njihovo preživljenje, migraciju i diferencijaciju. Miševi tretirani mišjim živčanim matičnm stanicama, ljudskim stanicama sluznice usne šupljine te netretirani miševi će biti uspoređeni - oslikani na magnetnoj rezonanci (Bruker 7T) i praćeni u nizu testova zdravstvenog statusa. Na taj način ćemo zaključiti o brzini njihovog oporavka. Očekujemo da će matične stanice usne šupljine čovjeka zbog svojeg podrijetla, pozitivnih rezultata na modelima neurodegeneracije i ozljede te naših preliminarnih rezultata pokazati visok potencijal za liječenje ishemijske bolesti mozga. Ukoliko se naša hipoteza potvrdi, ove će stanice zbog svoje dostupnosti, ektodermalnog podrijetla i terapijskog potencijala biti predložene kao stanice prvog izbora u kliničkim pokusima na pacijentima oboljelima od moždanog udara. ]]></summary_hr><summary_en><![CDATA[Ischemic brain damage is the most common form of stroke and represents one of the largest medical problems of the human society. In this project we will, for the first time, analyze therapeutic potential of recently discovered ectodermal stem cells from the oral mucosa (hOMSC) for treatment of brain ischemia. In preliminary experiments we have shown that hOMSC can be easily isolated from the mouth cavity of the patients and because of their origin – they give rise to neurons and glia. After isolation of cells, in collaboration with University of Zagreb School of Dentistry, we will analyze cell proliferation, differentiation potential and survival during cultivation in vitro . We will analyze markers of differentiation by immunhistochemistry and RT PCR in the period of 14 days and results obtained in normal conditions will be compared to in vitro hypoxia. Difference in cell response will be additionally analyzed on the level of transcriptome  which will be performed by New York University Abu Dhabi. In the next group of experiments we will transplant hOMSC in the animal model of stroke. In two time points, 7 and 30 days after transplantation we will describe their survival, migration and differentiation. Mice treated by hOMSC, NSC and untreated group will be tested in standardized tests of mouse Health status and imaged on MRI (Bruker, 7T). This will allow to conclude about histological and functional recovery of tested mice. We expect that, based on their embryonic origin, positive results on animal models of neurodegeneration and nerve damage and our promising preliminary results, hOMSC will exhibit beneficial effects for animals affected by stroke. If our hypothesis will be confirmed, hOMSC will be, because of their easy access, ectodermal origin and therapeutic potential, suggested as the perfect candidate for clinical trials on patients affected by stroke. ]]></summary_en></project><project>
<id>9610</id><title_hr><![CDATA[Pametne usluge usmjerene čovjeku u interoperabilnim i decentraliziranim okolinama Interneta stvari]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5079</user_id><user_firstLast_name>Ivana Podnar Žarko</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-1430</code><acronim><![CDATA[IoT4us]]></acronim><duration>01.10.2020 - 31.03.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>856054</team_members_id><team_members_names><![CDATA[ Doktorand: Ivan Čilić ]]></team_members_names><keywords_hr><![CDATA[Internet stvari (IoT), interoperabilnost, sigurnost, privatnost, tehnologija Blockchain, distribuirana digitalna knjiga, kognitivne usluge]]></keywords_hr><keywords_en><![CDATA[Internet of Things (IoT), interoperability, security, privacy, Blockchain, Distributed Ledger Technology, cognitive services]]></keywords_en><summary_hr><![CDATA[Internet stvari (IoT) je identificiran kao revolucionarna tehnologija koja donosi digitalnu transformaciju u mnoga područja te stvara značajan utjecaj na cjelokupno ljudsko društvo. Omogućava ispreplitanje fizičkog i digitalnog svijeta pomoću umreženih uređaja postavljenih u našu okolinu kojima rukuju korisničke aplikacije i usluge, dok njima upravljaju programske platforme. Međutim, semantička i sintaktička nekompatibilnost postojećih platformi ograničava širenje i bolje prihvaćanje IoT-rješenja u praksi te ih ograničava na određene domene ili ogledne projekte. Projekt IoT4us usvaja i nadograđuje aktualne rezultate proizašle iz projekta H2020 symbIoTe tijekom kojega je razvijena međuopremu otvorenog kôda za interoperabilnost Interneta stvari te je uspostavljen početni ekosustav interoperabilnih IoT-platformi, pokrećući tako novi val inovativnih aplikacija i usluga nad različitim domenama i platformama. IoT4us će nastaviti daljnji razvoj tog ekosustav kako bi stvorio interoperabilnu, decentraliziranu, dinamičnu i sigurnu IoT-okolinu koja čuva privatnost korisnika, a pritom se oslanja na računalne resurse na rubu mreže. IoT4us će u takvim dinamičnim okruženjima omogućiti autonomne i kognitivne IoT usluge usmjerene čovjeku i u skladu s potrebama korisnika. Provedeno istraživanje će pridonijeti nastanku IoT-rješenja sljedeće generacije koja su prikladna za mreže 5G, kroz masovno postavljanje IoT-uređaja s osnovnim ciljem ponude praktičnih i sigurnih aplikacija i usluga za krajnje korisnike koje štite njihovu privatnost. Kroz svoje istraživačke ciljeve, projekt će istražiti sljedeće izazovne teme: interoperabilne, dinamičke, decentralizirane i sigurne IoT-ekosustave namijenjene mrežama sljedeće generacije (uključujući mreže 5G), adaptivne komunikacijske protokole za učinkoviti prijenos podataka, inteligentne i kognitivne metode za IoT, tehnologiju Blockchain i mehanizme za očuvanje privatnosti u okolinama Interneta stvari.]]></summary_hr><summary_en><![CDATA[Internet of Things (IoT) is identified as a disruptive technology which brings digital transformation into many domains and creates significant impact on the overall human society. It enables the interweaving of the physical and digital world by means of networked devices placed in our environment that are operated by end user applications and services, while being managed by software platforms. However, semantic and syntactic incompatibilities of existing platforms are limiting a proliferation and higher adoption of IoT solutions in practice by restricting them to specific domains or pilot projects. The IoT4us project is adopting and building upon cutting-edge results of the H2020 project symbIoTe which has developed the Open Source middleware for IoT interoperability and established an initial ecosystem of interoperable IoT platforms steering a new wave of innovative IoT applications and services across different domains and platforms. IoT4us will evolve this ecosystem further to create interoperable, decentralised, dynamic, secure and privacy-preserving IoT environments that, in addition to cloud resources, also rely on edge/fog computing resources. IoT4us will enable human-centric, adaptive and cognitive IoT services and applications in line with user needs in dynamic environments. The performed research will contribute to the emergence of next-generation IoT solutions adequate for 5G networks and massive deployment of IoT devices with a primarily goal to offer practical, secure and privacy-preserving applications and services. Through its research objectives, the project will investigate the following challenging topics: interoperable, dynamic, decentralized and secure IoT ecosystems for next-generation networks (including 5G), adaptable communication protocols for efficient data transmission, intelligent and cognitive methods for IoT, Blockchain technology and privacy-preserving mechanisms for IoT.]]></summary_en></project><project>
<id>9615</id><title_hr><![CDATA[Otkrivanje organizacije i funkcije kolesterolove domene u plasma membrani fibroznih stanica leće oka uz primjenu fluorescentnih metoda]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6123</user_id><user_firstLast_name>Marija Raguž</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-3317</code><acronim><![CDATA[BioPhyCBD]]></acronim><duration>05.10.2020 - 05.04.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Split School of Medicine]]></institution_en><team_members_id>856215</team_members_id><team_members_names><![CDATA[ Doktorand: Ivan Mardešić ]]></team_members_names><keywords_hr><![CDATA[Očna mrena, kolesterol, domena dvosloja kolesterola, kristali kolesterola, očna leća, membrana fibroznih stanica, kisik, fluorescencija]]></keywords_hr><keywords_en><![CDATA[Cataract, cholesterol, cholesterol bilayer domain, cholesterol crystal, eye lens, fiber cell membrane, oxygen, fluorescence]]></keywords_en><summary_hr><![CDATA[Očna mrena je glavni uzrok sljepoće u svijetu. Operacija je trenutno jedini učinkovit tretman. Razlog za pojavu očne mrene je nepoznat, ali veliki broj dokaza ukazuje na to da prisutnost kolesterola i domena dvosloja kolesterola (DDKa) u očnoj leći pomaže u održavanju njene transparentnosti. Membrane očne leće igraju važnu ulogu u održavanju transparentnosti. Imaju jedinstven lipidni sastav i strukturu koja spriječava stvaranje očne mrene. U ovom istraživanju ćemo se usredotočiti na ulogu lipidnog dijela dvosloja membrane fibroznih stanica u održavanju homeostaze fibroznih stanica i leće. Prisutnost DDKa osigurava zasićenost okolnog fosfolipidnog dvosloja kolesterolom. Ove osobine održavaju glavna fizikalna svojstva lipidnih membrana leća konzistentnima i neovisnim o promjenama u fosfolipidnom sastavu. Dakle, DDKa pomažu u održavanju homeostaze membrane leće dok se membranski fosfolipidni sastav značajno mijenja sa starenjem. U ovom projektnom prijedlogu, prilagodit ćemo postojeće metode za pripremu modelnih membrana s visokim sadržajem kolesterola (odgovarajući modeli membrane fibroznih stanica) i primijeniti ih na ispitivanje membrana fibroznih stanica primjenjujući fluorescentne metode. Temeljem ovih istraživanja istražit ćemo promjene membrana fibroznih stanica koje se javljaju sa starenjem i pojavom mrene. Posebnu pažnju ćemo posvetiti određivanju glavnih razlika u organizaciji lipida u membranama leća osoba s mrenom i onih s prozirnim lećama iste starosti. U ovim studijama će se primjenjivati fluorescentna mikroskopija i protočna citometrija. Naš je cilj razjasniti kako se plazma membrane fibroznih stanica leće, a posebno njen lipidni dvosloj, mijenjaju tijekom starenja i stvaranja mrene, tako da se alternativne strategije za sprječavanje, usporavanje, napredovanje i liječenja mogu predložiti i razviti. ]]></summary_hr><summary_en><![CDATA[Cataracts are a major cause of blindness throughout the world. Surgery at present is the only effective treatment. The reason for the onset of cataracts is unknown, but a great deal of evidence suggests that the presence of high cholesterol content and cholesterol bilayer domains (CBDs) in the eye lens helps to maintain lens transparency. The eye lens membranes play important role in maintaining lens transparency. They have unique lipid composition and structure thought to protect against cataract formation. In this research we will focus on the role of the lipid bilayer portion of fiber cells membranes in maintaining fiber cell and lens homeostasis. The presence of the CBD ensures that the surrounding phospholipid bilayer is saturated with cholesterol. The saturating cholesterol content in fiber cell membranes keeps the bulk physical properties of lens lipid membranes consistent and independent of changes in phospholipid composition. Thus, the CBD helps to maintain lens-membrane homeostasis while the membrane phospholipid composition changes significantly with age. In this grant proposal, we will adapt recently existing methods for preparation of model membranes with high cholesterol content (appropriate models of fiber cell membranes) and apply them to investigate fiber cell membranes using fluorescent approaches. Based on these investigations we will examine changes in fiber cell membranes occurring with age and cataract formation. Special attention will be paid to determine major differences in the organization of lipids in lens membranes of people with cataractous and age-matched clear lenses. For this studies fluorescent microscopy and flow cytometry will be used. Our goal is to understand how fiber cell plasma membranes in the lens, in particular their lipid bilayer portion, change during aging and cataract formation so that alternative strategies for prevention, slowing the progression, and cure can be devised and evaluated.]]></summary_en></project><project>
<id>9621</id><title_hr><![CDATA[Razvoj održivog integriranog procesa proizvodnje biološki aktivnih izolata iz proizvodnih ostataka prehrambene industrije]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4717</user_id><user_firstLast_name>Mirela Planinić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-2828</code><acronim><![CDATA[POPI-WinCEco]]></acronim><duration>01.10.2020 - 30.09.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Prehrambena tehnologija, </scie_field_hr><scie_field_en>Food technology, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Prehrambeno-tehnološki fakultet]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Food Technology]]></institution_en><team_members_id>856193</team_members_id><team_members_names><![CDATA[ Doktorand: Gabriela Perković ]]></team_members_names><keywords_hr><![CDATA[proizvodni ostaci, biološki aktivni izolati, polifenoli, biološka obrada, ekstrakcija, sušenje, enkapsulacija, funkcionalni proizvod, bioraspoloživost]]></keywords_hr><keywords_en><![CDATA[food industry residues, bioactive isolates, polyphenols, biological treatment, extraction, drying, encapsulation, functional product, bioaccessibility]]></keywords_en><summary_hr><![CDATA[U prehrambenoj industriji zaostaju značajne količine proizvodnih ostataka (POPI) koji se uglavnom odbacuju iako po svom kemijskom sastavu imaju potencijal za daljnje korištenje u proizvodnji visokovrijednih produkata (npr. biološki aktivnih izolata bogatih polifenolnim spojevima, BAI). POPI biljnog porijekla su uglavnom teško razgradivi lignocelulozni materijali koji u svojoj strukturi sadrže inkorporirane polifenole, koji su zbog toga teško ekstraktibilni ili imaju nisku bioraspoloživost. Ekstrakcija teško topljivih polifenola zahtjeva dodatne postupke razgradnje (npr. kiselinama ili komercijalnim enzimima), koji povećavaju troškove proizvodnje i/ili nisu ekološki prihvatljivi. Fermentacija na čvrstim nosačima (solid-state fermentation, SSF) je bioproces koji ima veliki potencijal za pretvorbu otpada poljoprivredne i prehrambene proizvodnje u visokovrijedne produkte, među kojima su i BAI, na ekološki prihvatljiv način. Cilj ovog projekta je razviti održivi integrirani proces proizvodnje BAI-a iz POPI-a (trop grožđa; mekinje i pljevica žitarica) biljnog porijekla, pri čemu će se POPI prvo obraditi filamentoznim gljivama u SSF uvjetima, nakon čega će se koristiti za proizvodnju BAI a pomoću ekstrakcije otapalom. Razvit će se i protokoli stabilizacije BAI-a, primjenom suvremenih tehnologija (enkapsulacijom, sušenjem raspršivanjem, liofilizacijom), te će se odrediti antioksidacijska i antitumorska aktivnost BAI-a u in vitro uvjetima. Proizvedeni BAI koristiti će se kao dodaci u proizvodnji funkcionalnog keksa i srodnih proizvoda. Simuliranim procesom probave u in vitro uvjetima, ispitat će se bioraspoloživost polifenola iz BAI-a i funkcionalnog keksa. Rezultati predloženog projekta imat će pozitivne ekonomske i društvene utjecaje kroz razvoj ekološki prihvatljivog procesa proizvodnje BAI-a, minimiziranje količine otpada iz prehrambene industrije, povećanje dodane vrijednosti proizvoda, te indirektan utjecaj na ljudsko zdravlje kroz proizvodnju funkcionalnih proizvoda.]]></summary_hr><summary_en><![CDATA[There are significant amounts of residues from the food industry (POPI) which are usually discarded even though their chemical composition gives them the potential to be further used in the production of high-value products (e.g. biologically active polyphenol rich isolates, BAI). The POPI of plant origin are mostly lignocellulosic materials recalcitrant towards degradation, and incorporate polyphenolic compounds in its structure. Those polyphenolic compounds are difficult to be extracted, thus have low bioaccessibility. Extraction of low soluble polyphenols requires additional processes of degradation by e.g. acids or commercial enzymes, which increase the costs of production and/or are not environmentally friendly. Solid-state fermentation (SSF) has a great potential for conversion of agro-food industry residues into numerous high-value products, including BAI, in an environmentally friendly way. The goal of this project is to develop a sustainable integrated process for the production of BAI from POPI (grape pomace; bran and hull of cereals) where the POPI will be initially treated with filamentous fungi in SSF conditions. After the treatment it will be used for the production of BAI using solvent extraction. Protocols for the stabilization of BAI will be developed by using state-of-the-art technologies (spray drying, freeze-drying, encapsulation) and antioxidative and antitumor activity of BAI will be determined in in vitro conditions. Stable BAI will be used in the production of functional cookies and crackers. Through the simulated process of digestion in in vitro conditions, polyphenol bioaccessibility from the BAI and functional products will be tested. The results of the proposed project will have positive economic and social effects through development of environmentally friendly process for BAI production, minimization of food industry waste, increase of added product value, and indirect impact on human health through development of functional products.]]></summary_en></project><project>
<id>9622</id><title_hr><![CDATA[Biological and bioinspired structures for multispectral surveillance]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4857</user_id><user_firstLast_name>Hrvoje Skenderović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-8574</code><acronim><![CDATA[]]></acronim><duration>10.03.2021 - 09.03.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut za fiziku]]></institution_hr><institution_en><![CDATA[Institute of Physics in Zagreb]]></institution_en><team_members_id>865309</team_members_id><team_members_names><![CDATA[ Doktorand: Ali Mardan Dezfouli ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>9623</id><title_hr><![CDATA[Odgovori smeđih algi roda Cystoseira, koje formiraju staništa, na lokalne i globalne stresore ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>775</user_id><user_firstLast_name>Ljiljana Iveša</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-7315</code><acronim><![CDATA[HabCYS]]></acronim><duration>05.11.2020 - 04.11.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Interdisciplinarne prirodne znanosti, </scie_field_hr><scie_field_en>Interdisciplinary natural sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>862761</team_members_id><team_members_names><![CDATA[ Doktorand: Andrea Bilajac ]]></team_members_names><keywords_hr><![CDATA[Cystoseira, hridinasto dno, regresija, topografija, temperatura, bentoski cvat, hridinski ježinci, reproduktivna fenologija, restauracija]]></keywords_hr><keywords_en><![CDATA[Cystoseira species, rocky bottom, regression, topography, temperature, benthic mucilage, sea urchins, reproductive phenology, restoration]]></keywords_en><summary_hr><![CDATA[Sjeverni Jadran predstavlja najsjeverniji biogeografski sektor u Sredozemnom moru. Morsko dno uz zapadnu istarsku obalu uglavnom je hridinasto i stoga posebno pogodno za rast smeđih makroalgi roda Cystoseira. Zapadna obala Istre proteže se na oko 100 km zračne linije u smjeru sjever-jug. Ova posebna orijentacija utječe na veliku varijaciju oceanografskih varijabli i dinamiku valovanja. U zoni plime i oseke dominira naselje vrste Cystoseira amentacea, čija je maksimalna abundacija na jugu Istre. U predloženom projektu ispitat ćemo rasprostranjenost i gustoću naselja vrste C. amenatacea duž cijele istarske obale s posebnim osvrtom na određivanje topografije njenih staništa. Na području zapadne obale Istre zabilježena je opća regresija vrsta roda Cystoseira, prvenstveno u infralitoralnoj zoni. Prije 2015. godine, mješovita naselja smeđih makroalgi Cystoseira compressa, Cystoseira barbata, Cystoseira crinita, Cystoseira foeniculacea i Cystoseira humilis formirala su bogata staništa, koja su uglavnom dominirala na hridinastome dnu. Kronologija regresije naselja vrsta roda Cystoseira praćena je od proljeća 2015. do jeseni 2018. na nekoliko postaja. Na temelju navedenih opažanja u predloženom projektu procijenit ćemo trenutni status vrsta roda Cystoseira te moguće prve znakove regresije njihovih staništa uslijed lokalnih i globalnih stresora, među kojima ćemo veću pažnju posvetiti praćenju utjecaja povišenih ljetnih temperatura, bentoskog cvata te hridinskih ježinaca, kao brstioca. Nadalje, detaljnije ćemo ispitati reproduktivnu fenologiju vrsta roda Cystoseira, što je preduvjet za njihovu uspješnu reprodukciju te rast i razvoj, a testirat ćemo i neke ekonomski opravdane i učinkovite metode za eventualno obnavljanje nekih degradiranih staništa vrsta roda Cystoseira duž istarske obale.]]></summary_hr><summary_en><![CDATA[The northern Adriatic represents the northernmost biogeographic sector of the Mediterranean Sea. The sea bottom along the west Istrian Coast is mainly rocky and therefore particularly suitable for the growth of habitat-forming brown macroalgae of the genus Cystoseira. The west Istrian coast spans approximately 100 km air line in the north- south direction. This particular orientation produces large-scale gradients of oceanographic variables and wave action intensities.In intertidal zone Cystoseira stands were mainly composed of Cystoseira amentacea which attain maximum abundances along southern sectors of the coast. In the proposed project, we will inspect its distribution and abundance along the whole Istria Coast with special attention on determining C. amentacea habitat architecture. Starting from 2015, a general regression of Cystoseira species in subtidal zone was observed along the west Istrian Coast. Before 2015, mixed stands of Cystoseira compressa, Cystoseira barbata, Cystoseira crinita, Cystoseira foeniculacea and Cystoseira humilis formed flourishing forests, which predominantly covered the rocky bottom. The die-off chronology of Cystoseira forests was followed from spring 2015 to autumn 2018 at several stations. Based on those observations, in the proposed project we will evaluate Cystoseira current status and possible first signs of Cystoseira regression due to some local and global stressors, among which we will pay more attention to assessing the impact of high temperatures during summer, benthic mucilage formation and sea urchin grazing. Furthermore, we will inspect more in details the reproductive phenology of Cystoseira species that leads to the successful recruitment and we will test some cost-effective restoration methods for successfully restoring some degraded Cystoseira forests along the Istria coast. ]]></summary_en></project><project>
<id>9629</id><title_hr><![CDATA[Smart Cultural Tourism as a Driver of Sustainable Development of European Regions ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>7561</user_id><user_firstLast_name>Blanka Šimundić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-1864</code><acronim><![CDATA[]]></acronim><duration>18.01.2021 - 17.01.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, </scie_field_hr><scie_field_en>Economy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Ekonomski fakultet]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Economics, Business and Tourism]]></institution_en><team_members_id>862792</team_members_id><team_members_names><![CDATA[ Doktorand: Zvonimir Kuliš ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>9630</id><title_hr><![CDATA[Agrobioraznolikost - osnova za prilagodbu  i ublažavanje posljedica klimatskih promjena u poljoprivredi ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6613</user_id><user_firstLast_name>Dean Ban</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-2958</code><acronim><![CDATA[]]></acronim><duration>22.07.2020 - 08.10.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Institut za poljoprivredu i turizam]]></institution_hr><institution_en><![CDATA[Institute of Agriculture and Tourism in Poreč]]></institution_en><team_members_id>855778</team_members_id><team_members_names><![CDATA[ Doktorand: Nina Išić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>9633</id><title_hr><![CDATA[Eksperimentalna platforma za simulaciju endovaskularnog liječenja intrakranijskih aneurizmi]]></title_hr><title_en><![CDATA[]]></title_en><user_id>7650</user_id><user_firstLast_name>David Ozretić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-5698</code><acronim><![CDATA[ElPlaSTICA]]></acronim><duration>15.03.2021 - 14.03.2025</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Clinical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>865301</team_members_id><team_members_names><![CDATA[ Doktorand: Philipp Milović ]]></team_members_names><keywords_hr><![CDATA[intrakranijska aneurizma, endovaskularno liječenje, potpornica za preusmjeravanje protoka, metamaterijal, 3D ispis, inverzni problem]]></keywords_hr><keywords_en><![CDATA[intracranial aneurysm, endovascular treatment, flow diverter stent, metamaterial, 3D printing, inverse problem]]></keywords_en><summary_hr><![CDATA[Potpornice za preusmjeravanje protoka postale su nedavno novi način liječenja intrakranijskih aneurizmi. Takve potpornice usmjeruju krv mimo otvora aneurizme i smanjuju utok, s ciljem izazivanja hemostaze unutar njenog lumena i, u konačnici, njene okluzije. Još uvijek nije razjašnjeno zašto takvo liječenje u nekim slučajevima dovodi do potpune okluzije, dok u drugim aneurizma ostaje otvorena ili čak raste i rupturira. Brojna istraživanja smatraju kako je promjena u hemodinamici izazvana ugrađenom potpornicom odgovorna kako za razvoj okluzije, tako i rupture. Ovaj projekt nastoji donijeti nove spoznaje o hemodinamici intrakranijske aneurizme i arterije na kojoj se nalazi. Glavni cilj projekta je proučiti karakteristike protoka u aneurizmi prije i nakon ugradnje potpornice za preusmjeravanje protoka, i preslikati te karakteristike na eksperimentalnu platformu. Središnji dio platforme bit će realistična 3D ispisana replika aneurizme, stvorena na temelju podataka bolesnika i razvijena da bude realistična i po pitanju geometrije i mehaničkog ponašanja. Nakon uspješne validacije, eksperimentalna platforma mogla bi služiti za planiranje, pripremu i uvježbavanje endovaskularnog liječenja intrakranijskih aneurizmi.]]></summary_hr><summary_en><![CDATA[In recent years, flow diverter stents have emerged as a new way of treating intracranial aneurysms. A flow diverter stent diverts blood flow past the aneurysm opening and reduces inflow with the intent of causing hemostasis inside its lumen and, eventually, occlusion of the aneurysm. It is yet unclear why in some cases the treatment leads to complete occlusion, while in other cases the aneurysm stays open or even grows and ruptures. In many studies the change in hemodynamics induced by flow diverter is considered as main factor, both for promoting occlusion and rupture. This project aims to bring new insights into hemodynamics of intracranial aneurysm and its parent artery. The main goal of the project is to study the flow conditions in an aneurysm before and after the treatment with a flow diverter, and to replicate that conditions in an experimental platform. Central part of the platform will be a realistic 3D printed replica of an aneurysm, created from patient data and developed to be realistic both in terms of geometry and mechanical behaviour. Upon successful validation, experimental platform could be used for planning, preparation and training of endovascular treatment of intracranial aneurysms.]]></summary_en></project><project>
<id>9638</id><title_hr><![CDATA[Kvaliteta života u stambenim naseljima iz socijalističkog i postsocijalističkog razdoblja: komparativna analiza između Slovenije i Hrvatske]]></title_hr><title_en><![CDATA[Quality of living in the housing estates of the socialist and post-socialist era: A comparative analysis between Slovenia and Croatia]]></title_en><user_id>6259</user_id><user_firstLast_name>Anđelina  Svirčić Gotovac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IPS</proposal_type><proposal_call>2020-01</proposal_call><code>IPS-2020-01-7036</code><acronim><![CDATA[HESC]]></acronim><duration>15.10.2020 - 14.10.2023</duration><status>Završio</status><financ_value>94.365,92 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Sociologija, Ekonomija, </scie_field_hr><scie_field_en>Sociology, Economy, </scie_field_en><institution_hr><![CDATA[Institut za društvena istraživanja]]></institution_hr><institution_en><![CDATA[Institute for Social Research in Zagreb]]></institution_en><team_members_id>4796, 5850, 26645, 19366, 864948, 24073, 865093, </team_members_id><team_members_names><![CDATA[Tihomir Jukić, Jelena  Zlatar Gamberožić, Sonja Podgorelec, Željka Kordej-De Villa, Ratko Đokić, Mirjana Adamović, Anamaria Klasić, ]]></team_members_names><keywords_hr><![CDATA[kvaliteta života, stambena naselja, socijalističko razdoblje, postssocijalstičko razdoblje, komparativna analiza, Hrvatska, Slovenija]]></keywords_hr><keywords_en><![CDATA[quality of living, housing estates, socialism, post-socialism, comparative analysis, Croatia, Slovenia]]></keywords_en><summary_hr><![CDATA[U planiranom projektu fokus je na kvaliteti života u stambenim naseljima koja su izgrađena u razdoblju socijalističkog društveno-političkog i ekonomskog sustava te u razdoblju nakon prijelaza na tržišnu ekonomiju (postsocijalizam). Polazi se od hipoteze da su različite društvene okolnosti koje karakteriziraju postsocijalističko razdoblje donijele nove zahtjeve i potrebe u kvaliteti života stanovnika jer su naselja iz socijalističkog razdoblja postala manje atraktivna za život, jer stanovnici imaju nove vrijednosti i potrebe u pogledu kvalitete života i veća očekivanja za boljim stambenim standardom i kvalitetom stambenog okruženja. Istraživanje je osmišljeno kao komparativno, jer se testira hipoteza za dvije države - Sloveniju i Hrvatsku, koje imaju isti temelj za nastanak velikih stambenih naselja izgrađenih tijekom socijalističkog razdoblja. Bez obzira na promjene i razlike, velika stambena naselja iz socijalizma u obje zemlje i dalje predstavljaju značajan udio ukupnog stambenog fonda, za koji se pretpostavlja da nije adekvatan te da zbog zastarjelosti i promijenjenih vrijednosti treba cjelovitu obnovu. Međutim, nijedna od navedenih zemalja nije usvojila nacionalnu strategiju obnove velikih stambenih naselja ili smjernice za osiguranje više kvalitete stambenog i životnog okruženja. Krajnji je cilj istraživačkog projekta stoga definirati - s gledišta kvalitete života - smjernice i preporuke za odgovarajuću obnovu stambenih naselja iz socijalističkog razdoblja i za planiranje novih stambenih naselja u Sloveniji i u Hrvatskoj. Osnova za oblikovanje prijedloga za pripremu obje nacionalne strategije bit će sličnosti i razlike u percepcijama kvalitete života stanovnika stambenih naselja i njihovih potreba u odnosu na promijenjene vrijednosti povezane s načinom života. Istraživanje će stoga biti izvorno, a razvijene smjernice bit će relevantne i za ostale postsocijalističke zemlje.]]></summary_hr><summary_en><![CDATA[The focus is on the quality of living in the housing estates built in the period of the socialist socio-political and economic system and the period after the transition towards market economy (the post-socialist era). The hypothesis is that the various social circumstances characterizing the post-socialist period have brought new demands and needs in residents&#39; quality of living. The settlements from the socialist period have become less attractive for living, because residents have new values and needs regarding the quality of living, and higher expectations towards a better housing standard and a better quality of the living environment. The research is conceptualised as comparative, because the hypothesis is tested for two countries – Slovenia and Croatia. Both countries have the same foundation for the occurence of large housing settlements built during the socialist period. Large housing settlements from socialism still represent a significant proportion in total housing in both countries, which is presumed to be inadequate and in need of a comprehensive renovation, due to obsolence and changed values. None of the mentioned countries has adopted a national strategy of the renovation of large housing settlements, or the directives for assuring higher quality of the housing and living environment. It is therefore the overall goal of the research project to define, from the viewpoint of the quality of living, the guidelines and recommendations for adequate renovation of the housing settlements from the socialist period and for planning new housing settlements. The basis for outlining the proposal for the preparation of both national strategies will be the similarities and differences in understanding and perceptions of the quality of living among residents of housing settlements, in relation to changed values regarding the way of living. The research will therefore be original and the guidelines developed will be relevant for other post-socialist countries.]]></summary_en></project><project>
<id>9656</id><title_hr><![CDATA[Strukturna karakterizacija faktora uključenih u popravak unakrsnog vezanja DNA-protein]]></title_hr><title_en><![CDATA[Structural characterization of factors involved in DNA-protein crosslink repair]]></title_en><user_id>4272</user_id><user_firstLast_name>Marta Popović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IPS</proposal_type><proposal_call>2020-01</proposal_call><code>IPS-2020-01-4225</code><acronim><![CDATA[CRO-SI-LINK]]></acronim><duration>15.10.2020 - 14.01.2024</duration><status>Završio</status><financ_value>199.017,85 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, Kemija, </scie_field_hr><scie_field_en>Biology, Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>28938, 29045, 865219, 27233, </team_members_id><team_members_names><![CDATA[Nives Ivić, Cecile Otten, Marin Kutnjak, Ivan Antičević, ]]></team_members_names><keywords_hr><![CDATA[Oštećenja DNA, unakrsno vezanje DNA-protein (DPC), SPRTN proteaza, p97, ACRC, struktura, krio-elektronska mikroskopija, rendgenska kristalografija ]]></keywords_hr><keywords_en><![CDATA[DNA damage, DNA-protein crosslinks (DPCs), SPRTN protease, p97, ACRC, structure, cryo-electron microscopy, x-ray crystallography]]></keywords_en><summary_hr><![CDATA[Unakrsna veza DNK-protein (eng. DNA-protein crosslink; DPC) je DNK lezija sa štetnim učincima na organizam, uključujući pojavu tumora, preuranjeno starenje i neurodegenerativne bolesti. DPC-i se pojavljuju usred nepovratnog kovalentnog vezanja proteina na DNK i kao takvi narušavaju sve DNK transakcije: replikaciju, transkripciju i popravak. Popravak DPC-a (DPCR) je stoga esencijalan stanični put koji se sve do nedavnih otkrića proteaza Wss1 i SPRTN nije smatrao posebnim putom popravka DNK oštećenja. Trenutno se malo zna o molekularnim mehanizmima i strukturama čimbenika uključenih u DPCR.  Do danas, strukturne informacije o DPC-ovima i DPCR čimbenicima ograničene su na fragment koji sadrži aktivno mjesto SPRTN proteaze. Podaci na modelu kvasca ukazuju da SPRTN vjerojatno djeluje s ATP-ovisnom segregazom p97 obitelji AAA, još jednim bitnim proteinom povezanim s DPCR-om. Povrh toga, nedavno smo pronašli novu potencijalnu proteazu, ACRC (syn. GCNA), za koju se pokazalo da je povezana s DPCR-om. Trenutno nedostaju strukturni podaci o interakciji SPRTN-a sa DPC supstratima i p97 segregazom, kao i biokemijski i strukturni podaci o ACRC-u. Cilj nam je (1) okarakterizirati SPRTN:p97 kompleks i pretpostavljenu proteazu ACRC in vitro i in vivo, i (2) riješiti strukture humanih kompleksa SPRTN:DPC i SPRTN:p97 kao i strukturu ACRC proteina. Kompleksi SPRTN-a sa modelnim DPC-om i p97-om biti će rekonstituirani in vitro. Za dobivanje struktura visoke razlučivosti koristiti će se state-of-the-art krio-elektronski mikroskop sa faznom pločom i direktnim detektorom elektrona, dok će se za rješavanje strukture ACRC-a koristiti kristalografija zbog male veličine proteina. Predloženo istraživanje otkriti će mehanizme djelovanja DPCR-a na molekularnoj razini te pridonijeti području razvijanja inhibitora p97-a i SPRTN-a u svrhu liječenja raka i modulacije procesa starenja.]]></summary_hr><summary_en><![CDATA[DNA-protein crosslinks (DPCs) are DNA lesions with adverse effects on the organismal level, including cancer, premature aging and neurodegenerative diseases. DPCs occur when a protein irreversibly covalently binds to DNA and thus impair all DNA transactions: replication, transcription and repair. DPC repair (DPCR) is therefore an essential cellular pathway which was overlooked due to the fact that it was not considered to be a distinct DNA damage repair pathway until recent discoveries of proteases Wss1 and SPRTN with central role in the pathway. However, molecular mechanisms and structural knowledge behind the protease-mediated DPCR is lacking. To date, structural information on DPCs and DPCR factors is limited to a fragment containing the active site of SPRTN protease. Data from yeast indicate that SPRTN might work in concert with the ATP-dependent AAA family segregase p97, another essential protein linked to DPCR. In addition, we have recently found another SPRTN-like putative protease, ACRC (syn. GCNA) shown to be linked to DPCR. Currently, structural data on SPRTN interaction with DPC substrates and p97 segregase is lacking, as well as biochemical and structural data on ACRC. We aim to (1) characterize SPRTN:p97 complex and putative protease ACRC in vitro and in vivo, and (2) solve structures of human SPRTN:DPC and SPRTN:p97 complexes as well as the structure of ACRC protein. SPRTN complexes with a model DPC and a p97 will be reconstituted in vitro.  Structures of high resolution will be obtained using a state-of-the-art cryo-EM facility with phase plate and a direct electron detector, while the structure of ACRC will be solved using X-ray crystallography due to the small size of the protein. The proposed research will unravel the mechanisms underlying DPCR on a molecular level and will contribute to the field of p97 and SPRTN inhibitor development for the purpose of cancer treatment and modulation of aging processes.]]></summary_en></project><project>
<id>9660</id><title_hr><![CDATA[Gluonsko zasićenje u visoko energetskim proton-jezgra sudarima - istraživanje novih fenomenoloških smjernica]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5932</user_id><user_firstLast_name>Sanjin Benić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-1335</code><acronim><![CDATA[SAT-PHENO]]></acronim><duration>01.09.2021 - 31.08.2025</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>865052</team_members_id><team_members_names><![CDATA[ Doktorand: Eric Andreas Vivoda ]]></team_members_names><keywords_hr><![CDATA[high energy collision, proton structure, nucleus structure, quantum chromodynamics, gluon, quark, gluon saturation]]></keywords_hr><keywords_en><![CDATA[visoko energetski sudari, struktura protona, struktura jezgre, kvantna kromodinamika, gluon, kvark, gluonsko zasićenje]]></keywords_en><summary_hr><![CDATA[Pojava gluonskog zasićenja modificira spektar i korelacije proizvedenih čestica u sudarima visokih energija. To je temeljno predviđanje efektivne teorije QCD-a na visokim energijama - Color Glass Condensate (CGC). Učinci zasićenja povećavaju se za jezgre i stoga je najbolja opcija razmatranje sudara proton-jezgra. Do sada ne postoje čvrsti eksperimentalni dokazi o gluonskom zasićenju. Kako bismo riješili ovaj problem, predlažemo da istražimo nove CGC observable. Foton i dilepton su posebno obećavajući jer su čista konačna stanja. Njihove fenomenološke implikacije za RHIC i LHC svakako zaslužuju više pozornosti za koje bi ovaj projekt bio vrlo pogodan. Sudaranje poprečno polariziranih protona s jezgrom je još jedan način izučavanja CGC-a jer različiti doprinosi nose različitu nuklearne ovisnost. Paralelno s tim, možemo bolje razumjeti strukturu polariziranog protona. Nedavno su polarizirani sudari p + A postali stvarnost na RHIC-u - za sada je ovo potpuno otvoreno polje te ga stoga svakako vrijedi istražiti. Dobiveni rezultati pružaju temeljni uvid u strukturu protona ili jezgre na visokoj energiji, ograničavaju početne uvjete za A + A sudare i nude kvantitativne smjernice za buduće e + A sudare.U ovom petogodišnjem projektu osnovala bi se istraživačka skupina na Fizičkom odsjeku Prirodoslovno-matematičkog fakulteta Sveučilišta u Zagrebu koja će se sastojati od doktorskog studenta (godina 1-4), dva postdoktoranda (godine 2-3 i 4-5) i mene kao glavnog istraživača. Tijekom svog postdoktorskog usavršavanja u inozemstvu surađivao sam s vrhunskim stručnjacima kako bih napravio nekoliko originalnih radova u ovom području. S kompletnim deficitom CGC stručnjaka u Hrvatskoj ovo je savršena prilika za pokretanje istraživačke CGC skupine. Ovim projektom predstavit će se novo i dinamično istraživačko područje fizičkoj zajednici u Hrvatskoj, uspostaviti nove veze s vrhunskim istraživačkim centrima, čime će se ojačati njezin položaj na znanstvenoj karti svijeta.]]></summary_hr><summary_en><![CDATA[The appearence of gluon saturation modifies the spectrum and correlations of particle production in high energy collisions. It is a fundamental prediction of the high-energy theory of QCD - Color Glass Condensate (CGC). Saturation effects are enhanced for the nuclei and so the best option is to consider proton-nucleus collisions. Up till now there is no firm experimental evidence of gluon saturation. To solve this problem we suggest to explore new CGC observables. Photon and dilepton are especially promising as they are clean final states. Their phenomenological implications for RHIC and LHC definitely deserve more attention for which this project would be very suitable. Colliding transversely polarized protons off a nucleus is another way of constraining CGC as different contributions carry different nuclear dependence. In parallel, we can use it to understand more about the structure of the polarized proton. Recently, polarized p+A collisions have become a reality at RHIC - so far this is a completely open field and so it is definitely worth exploring. The obtained results offer first-principle insight into the structure of the proton or the nuclei at high energy, constrain the initial conditions for A+A collisions and offer quantiative guidelines for future e+A collisions.In this 5 year project a research group would be established at the Physics Department, Faculty of Science, University of Zagreb consisting of a doctoral student (year 1-4), two postdoctoral researchers (year 2-3 and year 4-5) and myself as a principal investigator. During my postdoc abroad I have collaborated with top experts to produce several original works in the field. With a total deficit of CGC experts in Croatia this is a perfect opportunity to start a CGC research group. This project will introduce a young and vibrant research field to the physics community in Croatia, establish new connections with top research centers, strengthening its position on the scientific map of the world. ]]></summary_en></project><project>
<id>9670</id><title_hr><![CDATA[Razvoj gradivnih blokova za novu europsku kvantnu komunikacijsku mrežu]]></title_hr><title_en><![CDATA[Development of building blocks for new European quantum communication network]]></title_en><user_id>5697</user_id><user_firstLast_name>Mario Stipčević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IPS</proposal_type><proposal_call>2020-01</proposal_call><code>IPS-2020-01-2616</code><acronim><![CDATA[DEMON]]></acronim><duration>01.10.2020 - 30.09.2023</duration><status>Završio</status><financ_value>199.084,08 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>29150, 1314, 5410, 5029, 23999, 25234, </team_members_id><team_members_names><![CDATA[Matej Peranić, Martin Lončarić, Ticijana Ban, Damir Aumiler, Danijel Buhin, Mateo Kruljac, ]]></team_members_names><keywords_hr><![CDATA[quantum communication, quantum memory, entangled photons, single-photon detectors, electromagnetic induced transparency]]></keywords_hr><keywords_en><![CDATA[quantum communication, quantum memory, entangled photons, single-photon detectors, electromagnetic induced transparency]]></keywords_en><summary_hr><![CDATA[Kvantna tehnologija obećava aplikacije koje nadilaze mogućnosti utvrđenih tehnologija. Poznati primjeri su kvantna računala i kvantno pojačano osjećanje. Da bi se iskoristio puni potencijal kvantne tehnologije trebat će uspostaviti kvantne mreže koje distribuiraju kvantne resurse između udaljenih komunikacijskih partnera. U utrci za kvantnu tehnologiju uloženi su značajni globalni napori u realizaciji središnjih građevnih blokova i infrastrukture za ovu novu tehnologiju. Kina je lansirala prvi kvantni satelit i uspostavili su veliku mrežu rudimentarnih kvantnih čvorova. Prošle godine, SAD je donio Nacionalni zakon o kvantnoj inicijativi, usredotočivši napore na kvantne mreže, kvantnu komunikaciju i kvantno računanje. U Europi je kvantni vodeći brod bio važan korak kako bi bili u tijeku s tim razvojem, ali uglavnom je potaknuo istraživačke napore u nekim dijelovima zapadne Europe. Cilj ovog projekta je realizacija središnjih građevnih blokova za izgradnju kvantne mreže u jugoistočnoj Europi. Ti će napori ojačati kvantnu stručnost u Sloveniji i Hrvatskoj i uspostaviti naše zemlje kao konkurentne partnere u kvantnoj tehnologiji. Konkretno, shvatit ćemo nekoliko ključnih sastojaka kvantnog interneta: uskopojasni izvori kompatibilni s telekom valnim duljinama i s kvantnim memorijama temeljenim na atomima. To će omogućiti demonstraciju dokaza o glavnom nedostajućem sastojku u globalnim kvantnim mrežama: kvantnom repetitoru.]]></summary_hr><summary_en><![CDATA[Quantum technology promises applications beyond the capabilities of established technologies. Well-known examples are quantum computers and quantum-enhanced sensing. To harness the full potential of quantum technology will require the establishment of quantum networks that distribute quantum resources between distant communication partners. In what has become a quantum technology race, significant global efforts have been put into realizing the central building blocks and the infrastructure for this new technology. China launched the first quantum satellite, and they established a large network of rudimentary quantum nodes. Last year, the US enacted the National Quantum Initiative Act, focusing efforts towards quantum networks, quantum communication and quantum computing. In Europe, the Quantum Flagship in Europe was an important step to keep abreast of these developments, but it mostly boosted research efforts in some parts of Western Europe. The present project aims to realize central building blocks for building a quantum network in South-Eastern Europe. These efforts will strengthen quantum expertise in Slovenia and Croatia and establish our countries as competitive partners in quantum technology. In particular, we will realize several key ingredients of a quantum internet: narrow-band sources compatible with telecom wavelengths and with atom-based quantum memories. This will allow a proof-of-principle demonstration towards the key missing ingredient for global quantum networks: a quantum repeater.]]></summary_en></project><project>
<id>9671</id><title_hr><![CDATA[Visokoprotočno Nanopore-sekvenciranje mikrobnih genoma u rješavanju problema dijagnostike i epidemiologije biljnih patogena]]></title_hr><title_en><![CDATA[Nanopore high-throughput sequencing for resolution of problems in plant pathogen epidemiology and diagnostics]]></title_en><user_id>11295</user_id><user_firstLast_name>Dijana Škorić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IPS</proposal_type><proposal_call>2020-01</proposal_call><code>IPS-2020-01-2960</code><acronim><![CDATA[NanoPhyto]]></acronim><duration>01.10.2020 - 15.01.2024</duration><status>Završio</status><financ_value>173.900,39 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Biotehnologija, Poljoprivreda, </scie_field_hr><scie_field_en>Biotechnology, Agriculture, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>12617, 26493, 13634, 19471, 26015, </team_members_id><team_members_names><![CDATA[Martina Šeruga Musić, Marina Drčelić, Antun Alegro, Dorotea Grbin, Martin Jagunić, ]]></team_members_names><keywords_hr><![CDATA[biljni virusi, viroidi, fitoplazme, visokoprotočno sekvenciranje, Nanopore]]></keywords_hr><keywords_en><![CDATA[plant virus, viroid, phytoplasma, high throughput sequencing, Nanopore]]></keywords_en><summary_hr><![CDATA[Cilj ovog projekta je korištenje sustava za uzgoj rajčice kao sustava za razvoj i poboljšanje Nanopore tehnologije sekvenciranja visoke protočnosti (HTS) u otkrivanju složenih etiologija biljnih bolesti. Biljne bolesti mogu imati složenu etiologiju koja podrazumijeva kompleks biljnih patogena. Kompleks može uključivati jedan ili više vrsta virusa s različitim tipovima genoma (npr. dvolančani DNA, jednolančani RNA, dvolančani RNA), viroide (male kružne RNA kao značajne biljne patogene), ponekad i fitoplazme, te njihove kombinacije. Divlje biljke izvan granica područja uzgoja rajčice bit će uključene u analize kao potencijalni rezervoarni domaćini patogena. Osim toga, testirat će se voda za navodnjavanje za koju je zabilježeno da može poslužiti za rasprostranjivanje biljnih patogena, ali još uvijek je to slabo istražen način prijenosa bolesti. Ovaj pristup trebao bi pružiti uvid u molekularnu epidemiologiju bolesti rajčice i ekologiju odabranih (agro)ekosustava. Dobiveni „metagenomski snimak situacije“ istraživanih (agro)ekosustava rajčice unaprijedit će biljnu virologiju i općenito mikrobnu ekologiju u Hrvatskoj. Pod vodstvom slovenskog tima projekt će s jedne strane osigurati sustav testiranja za poboljšanje primjene Nanopore HTS u fitopatologiji i mikrobiologiji okoliša. Osim unaprijeđenja istraživačkih kapaciteta hrvatskog tima, uvest će u Hrvatsku nove HTS tehnologije u biljnoj molekularnoj mikrobiologiji i pružiti nove podatke o pojavi i raznolikosti virusa rajčice i drugih virusima sličnih patogena. Ovakav uvid u bolesti rajčice može rezultirati novim idejama za razvoj strategija suzbijanja tih bolesti temeljenim na znanju molekularne epidemiologije i ekologije.]]></summary_hr><summary_en><![CDATA[The aim of this project is to make use of the tomato cultivation systems as a case study to demonstrate and improve the usefulness of Nanopore high throughput sequencing (HTS) technology in deciphering complex aetiologies of plant diseases. The plant pathogen complexes may involve one or more viruses of different genome types (e.g. dsDNA, ssRNA, dsRNA), viroids (small circular RNA plant pathogens), possibly phytoplasmas, and their combinations. The wild plants out of the tomato cultivation area borders will be included in the analyses as potential pathogen reservoirs. In addition, the irrigation waterways will be tested as possible, but under investigated, pathogen transmission routes. This approach should provide insight into the molecular epidemiology of the tomato diseases and ecology of the selected (agro)ecosystems. The obtained metagenomic screenshot of the surveyed tomato (agro)ecosystems will help developing plant virology and microbial ecology research in Croatia. The project will provide the testing system for the improvement of Nanopore HTS application in plant pathology and environmental microbiology pioneered by the Slovenian team. Besides building research expertise in Croatia, it will introduce novel HTS technologies in plant molecular microbiology and provide new data on the occurrence and diversity of tomato viruses and other virus-like pathogens. This glimpse into tomato diseases may result in novel ideas for the development of the disease management strategies based on the molecular epidemiology and ecology knowledge.]]></summary_en></project><project>
<id>9706</id><title_hr><![CDATA[Modeli i prakse globalne i kulturne razmjene i pokret Nesvrstanih zemalja. Istraživanja prostorno-vremenske kulturne dinamike ]]></title_hr><title_en><![CDATA[Models and Practices of Global Cultural Exchange and Non-aligned Movement. Research in the Spatio-Temporal Cultural Dynamics]]></title_en><user_id>6142</user_id><user_firstLast_name>Ljiljana Kolešnik</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IPS</proposal_type><proposal_call>2020-01</proposal_call><code>IPS-2020-01-3992</code><acronim><![CDATA[GLOB_Exchange]]></acronim><duration>15.10.2020 - 14.01.2024</duration><status>Završio</status><financ_value>99.818,57 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Interdisciplinarne humanističke znanosti, Filozofija, Povijest, Povijest umjetnosti, Znanost o umjetnosti, Etnologija i antropologija, </scie_field_hr><scie_field_en>Interdisciplinary humanities, Philosophy, History, Art history, Arts, Ethnology and anthropology, </scie_field_en><institution_hr><![CDATA[Institut za povijest umjetnosti]]></institution_hr><institution_en><![CDATA[Institute of Art History, Zagreb]]></institution_en><team_members_id>6333, 4649, 17659, 26996, 29185, 21394, 7018, 865082, </team_members_id><team_members_names><![CDATA[Sanja Horvatinčić, Tamara  Bjažić Klarin, Nikola Bojić, Vlatka Lemić, Tihana Puc, Sanja Sekelj, Paul Stubbs, Martina Bobinac Bobinac, ]]></team_members_names><keywords_hr><![CDATA[digitalna povijest umjetnosti, kulturna razmjena, Pokret nesvrstanih zemalja, modernizam, dekolonizacija, virtualna realnost, vizualizacija mreža]]></keywords_hr><keywords_en><![CDATA[digital art history, cultural exchange, Non-aligned Movement, modernism, decolonization, virtual reality, network visualization]]></keywords_en><summary_hr><![CDATA[Predloženi projekt usmjeren je istraživanjima modela međunarodne kulturne razmjene nakon 1960-ih godina. Njegova je hipoteza da su ubrzani procesi dekolonizacije tijekom toga desetljeća, uokvireni artikulacijom kulturnih potreba i kulturnim politikama afričkih, azijskih i latinoameričkih zemalja tek oslobođenih kolonijalne vlasti, rezultirali novim institucionalnim mehanizmima i novim modelima / praksama kulturne razmjene, koji su radikalno narušili dinamiku globalnog kulturnog i umjetničkog polja. Ovakav pristup dovodi u pitanje ideju kronoloških, linearnih tokova dominantnih kulturalnih, umjetničkih i političkih narativa. S promjenom dinamike i institucionalne konfiguracije globalnog kulturnog polja mijenjali su se i modeli kulturalnog prevođenja, a navedene promjene dokumentirat će se usporednom analizom kulturnih politika, organizacijskih metoda, tipova i medijskih formata kulturne razmjene Istočnog bloka, zapadne Europe, SAD-a i zemalja Pokreta nesvrstanih (Jugoslavije, Alžira, Tunisa, Ghane, Indije, Kube itd.). Pritom ćemo se posebno baviti zahtjevima 1960-ih i 1970-ih godina za etničkom, rasnom i rodnom emancipacijom, artikuliranim u polju vizualne kulture i umjetnosti, te načinima njihova posredovanja kroz oficijelne programe kulturne razmjene. S obzirom da je u fokusu projekta transnacionalna, globalna cirkulacija predmeta, osoba i ideja, drugi njegov važan cilj je razviti eksperimentalna, inovativna digitalna sučelja za dinamične prikaze kauzalnih odnosa među podatcima, te za multidimenzionalne mrežne vizualizacije koja će, zahvaljujući neposrednom &#39;uranjajućem&#39; iskustvu bivanja &#39;u podacima&#39;, nesumnjivo utjecati na ono što s njima činimo i na način na koji razumijevamo njihovu spoznajnu vrijednost. ]]></summary_hr><summary_en><![CDATA[The proposed project focuses on the research of the models of international cultural exchange after the 1960s. The hypothesis is that accelerated decolonization processes taking place in that decade, framed by the articulation of cultural needs and the cultural policies of African, Asian and Latin American countries, recently liberated from the colonial government, resulted in a new institutional mechanisms and new cultural exchange models / practices that radically disrupted the dynamics of the global cultural and artistic field. Such perspective challanges the notion of chronological, linear flows of dominant cultural, artistic and political narratives. Along with the change in the dynamics and institutional configuration of the global cultural field, models of cultural translation were also modified. These changes will be documented by a comparative analysis of cultural policies, organizational methods, types and media formats of cultural exchange among the countries of the Eastern Bloc, Western Europe, USA and countries of the Non-Aligned Movement (Yugoslavia, Algeria, Tunisia, Ghana, India, Cuba, etc.). We will thereby particularly address the demands of the 1960s and 1970s for ethnic, racial, and gender emancipation, articulated in the field of visual culture and arts, and ways of their mediation through official cultural exchange programs. Given that the project focuses on transnational, global circulation of objects, persons, and ideas, its second important objective is to develop experimental, innovative digital interfaces for dynamic representations of causal relationships between data, and for multidimensional network visualizations that, owing to an immediate &#39;immersive&#39; experience of being &#39;in the data&#39;, undoubtedly influence how we operate with them and the way in which we understand their cognitive value.]]></summary_en></project><project>
<id>9774</id><title_hr><![CDATA[Farmakokinetika intravenski i intramuskularno primijenjenog antivenoma u velikom animalnom modelu]]></title_hr><title_en><![CDATA[Pharmacokinetics of snake antivenom following intravenous and intramuscular administration in envenomed large animal model]]></title_en><user_id>1144</user_id><user_firstLast_name>Tihana Kurtović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2020-02</proposal_call><code>UIP-2020-02-1317</code><acronim><![CDATA[PKSheep]]></acronim><duration>01.03.2021 - 28.02.2026</duration><status>U tijeku</status><financ_value>264.118,39 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu]]></institution_hr><institution_en><![CDATA[University of Zagreb]]></institution_en><team_members_id>12959, 29371, 865053, </team_members_id><team_members_names><![CDATA[Maja Lang Balija, Ana Hećimović, Erika Gamulin, ]]></team_members_names><keywords_hr><![CDATA[antivenom, venom, farmakokinetika, put primjene, terapijska učinkovitost, veliki animalni model]]></keywords_hr><keywords_en><![CDATA[antivenom, venom, pharmacokinetics, administration route, therapy efficacy, large animal model]]></keywords_en><summary_hr><![CDATA[Parenteralna primjena antivenoma je okosnica terapije otrovanja izazvanih zmijskih ugrizom. Utjecaj puta primjene na njihovu djelotvornost nije sistematično istražen. Donedavno, farmakokinetika antivenoma je bila praćena samo u sistemskoj cirkulaciji, uglavnom animalnih modela. Uočeno je da kod i.m. primjene pristizanje antivenoma nije ni vremenski, ni količinski prilagođeno brzini kojom  venom dospijeva u krv. I.v. administracijom kompletna količina lijeka odmah dospijeva u krvožilni opticaj te je usklađenija s pojavnošću venoma. S vremenom je zaživjela hipoteza o i.v. primjeni kao boljem terapijskom pristupu. Naša recentna istraživanja na žrtvama ugriza također su uočila razlike u farmakokinetici antivenoma danog i.v. ili i.m., praćene u krvi, no one nisu utjecale na uspješnost liječenja. Nedavno je pokazano da bi neutralizacija venoma u limfnom sustavu mogla biti ključna za klinički ishod. Izgledno je da farmakokinetičko podudaranje venoma i antivenoma u krvotoku nije indikator terapijske učinkovitosti. Slaba biodostupnost uslijed i.m. primjene isto bi mogla biti irelevantna.Cilj našeg istraživanja je razotkrivanje optimalnog puta primjene u liječenju otrovanja s naglaskom na interakcije venoma i antivenoma u limfnom sustavu. Studiju farmakokinetike ćemo provesti na eksperimentalno otrovanim ovcama podvrgnutima uzorkovanju krvi i limfe. Mjerenjem koncentracija u ovisnosti o vremenu ćemo definirati učinak antivenoma na razinu s.c. injektiranog venoma u oba tjelesna odjeljka. Po prvi puta će farmakokinetika antivenoma te njegov neutralizacijski potencijal biti usporedno istraženi u ovisnosti o načinu unosa u organizam. Kako sigurnosni profili i.v. i i.m antivenoma nisu sustavno ispitani, u uzorcima seruma ćemo pratiti razinu anti-antivenom IgG-a u kao pokazatelja slabije imunogeničnog i terapijski sigurnijeg puta primjene. Konačno, istraživanjem ćemo obuhvatili hematološke parametre kako bi utvrdili učinkovitiji način administracije u suzbijanju kliničkih simptoma.]]></summary_hr><summary_en><![CDATA[Parenteral administration of antivenoms (AVs) is the mainstay in the snakebite envenoming therapy. Impact of the administration route on their effectiveness has never been systematically investigated. Until recently, AV pharmacokinetics was followed in the systemic circulation only, mostly using animal models. I.m. AV seems unadjusted in time and dose manner to the rapid appearance of venom (V) in blood. When given i.v., the whole amount of drug is straightaway available in systemic circulation, appearing more complied with V incidence. Hypothesis that i.v. route might be the better principle emerged. Our recent research on human victims also revealed differences in AV pharmacokinetics in blood when given i.v. or i.m., but they didn&#39;t appear to be relevant for therapy success. Recently, it was concluded that V neutralisation in lymphatic system might be of great importance for clinical outcome. Thus, V-AV pharmacokinetic matching in systemic circulation might not be the indicator of therapy success. Low bioavailability associated with i.m. route might be of lesser importance. Our research will aim for revealing optimal administration route in envenoming treatment, with emphasis on V-AV interplay in lymphatic system. Pharmacokinetics of i.m. and i.v. AV will be analysed in experimentally envenomed sheep that will be subjected to the blood and lymph sampling. By performing timed level measurements, the AV effect on decrement of V quantities in both body compartments will be defined. Pharmacokinetics and neutralisation potential of i.v. and i.m. AV will be comparatively investigated for the first time. Since safety profiles of i.v. and i.m. AVs have not been simultaneously examined for now, information on anti-AV IgGs development as a mark of the approach of lower immunogenicity and improved safety will be provided. Haematological parameters will be monitored to access and compare the potential of differently applied AVs to reverse V-induced clinical symptoms.]]></summary_en></project><project>
<id>9775</id><title_hr><![CDATA[Ekologija i toksičnost vrsta roda Pseudo-nitzschia u obalnim vodama srednjeg i južnog Jadrana]]></title_hr><title_en><![CDATA[Ecology and toxicity of the genus Pseudo-nitzschia in the coastal waters of the Central and Southern Adriatic Sea]]></title_en><user_id>5818</user_id><user_firstLast_name>Jasna Arapov</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2020-02</proposal_call><code>UIP-2020-02-3249</code><acronim><![CDATA[PSEUDOTOX]]></acronim><duration>31.01.2021 - 30.03.2026</duration><status>U tijeku</status><financ_value>262.196,57 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, Interdisciplinarne prirodne znanosti, </scie_field_hr><scie_field_en>Biology, Interdisciplinary natural sciences, </scie_field_en><institution_hr><![CDATA[Institut za oceanografiju i ribarstvo]]></institution_hr><institution_en><![CDATA[Institute of Oceanography and Fisheries]]></institution_en><team_members_id>6043, 5840, 28773, 866577, 22603, </team_members_id><team_members_names><![CDATA[Jelena Mandić, Mia Bužančić, Tina Pavelin, Tina Bonačić, Blanka Milić Roje, ]]></team_members_names><keywords_hr><![CDATA[Pseudo-nitzschia, taksonomija, toksičnost, molekularne analize, Jadransko more]]></keywords_hr><keywords_en><![CDATA[Pseudo-nitzschia, taxonomy, toxicity, molecular analyses, Adriatic Sea]]></keywords_en><summary_hr><![CDATA[Projektni prijedlog obuhvaća ekološko i taksonomsko istraživanje potencijalno toksičnog fitoplanktonskog roda Pseudo-nitzschia.  Danas ovaj rod dijatomeja čini 60 vrsta od kojih se polovica smatra toksičnim. Međutim, zbog postojanja kriptičnih i pseudo-kriptičnih vrsta determinacija vrsta roda Pseudo-nitzschia moguća je jedino kombiniranom primjenom molekularnih i morfoloških analiza. Glavni cilj predloženog istraživanja je uspostava istraživačke grupe koja će uvesti nove, dosad nekorištene istraživačke metode: Sanger sekvenciranje, DNA-metabarcoding i transmisijsku elektronsku mikroskopiju, u svrhu morfološke i molekularne karakterizacije populacija Pseudo-nitszchia. Istraživanje će se provesti tijekom jedne godine na četiri najvažnija uzgojna i izlovna područjima za školjkaše srednjeg i južnog Jadrana. Terenskim istraživanjem prikupit će se uzorci okolišnih i bioloških parametara kako bi se odredili uvjeti koji pogoduju razvoju Pseudo-nitzschia vrsta. Primjenom novih metoda detaljno će se odrediti sastav istraživanog roda i uspostaviti stanične kulture. Toksičnost staničnih kultura određivati će se pri standardnim i izmijenjenim uzgojnim uvjetima u eksprimentalnom dijelu projekta. Najvažniji znanstveni doprinos predloženog istraživanja će biti detaljno određivanje taksonomskog stastava roda Pseudo-nitzschia na istraživanim područjima, koje će za područje južnog Jadrana predstavljati prve podatke. Predloženim istraživanjem dobit će se prve saznanja o toksičnosti istraživanog roda, a rezultati analize DNA planktonske zajednice upotpuniti će dosadašnja taksonomska istraživanja elektronskom mikroskopijom. Rezultati istraživanja objavit će se u četiri znanstvena rada. Prikupljeni podaci bit će temelj za buduća istraživanja roda Pseudo-nitzshcia u Jadranskom moru.]]></summary_hr><summary_en><![CDATA[The project proposal covers an ecological and taxonomic study of the potentially toxic phytoplankton genus Pseudo-nitzschia. This genus of diatoms consists of 60 species, half of which are considered toxic. However, due to the existence of cryptic and pseudo-cryptic species, the determination of species of the genus Pseudo-nitzschia is only possible through the combined application of molecular and morphological analyses. The main objective of the proposed research is to establish a research group that will introduce new, previously unused research methods: Sanger sequencing, DNA metabarcoding and transmission electron microscopy, for the purpose of morphological and molecular characterisation of Pseudo-nitzschia populations. The research will be carried out during one year at four most important breeding and fishing areas for shellfish in the central and southern Adriatic. Field sampling of environmental and biological parameters will be carried out to determine conditions that favors the development of Pseudo-nitzschia species. The use of new methods will determine in detail the composition of the genus under study and establish cell cultures. Cell culture toxicity will be determined under standard and modified breeding conditions in the experimental part of the project. The most important scientific contribution of the proposed research will be to determine in detail the taxonomic status of the genus Pseudo-nitzschia in the studied areas, which will be the first data for the southern Adriatic area. The proposed research will gain the first knowledge about the toxicity of the studied genus, and the results of  analysis of the DNA of the planktonic community will complement current taxonomic research by electron microscopy. The research results will be published in four scientific papers. The data collected will be the basis for future research into the genus Pseudo-nitzschia in the Adriatic Sea.]]></summary_en></project><project>
<id>9778</id><title_hr><![CDATA[Onečišćenje zraka i biomarkeri učinka u ljudi]]></title_hr><title_en><![CDATA[Air Pollution and Human Biomarkers of Effect]]></title_en><user_id>87</user_id><user_firstLast_name>Goran Gajski</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2020-02</proposal_call><code>IP-2020-02-1192</code><acronim><![CDATA[HUMNap]]></acronim><duration>15.07.2021 - 14.07.2025</duration><status>Završio</status><financ_value>128.807,49 eur</financ_value><scie_area_hr>Interdiciplinarne znanosti, Biomedicina i zdravstvo, Prirodne znanosti, Tehničke znanosti, </scie_area_hr><scie_area_en>Interdisciplinary scientific area, Biomedicine and health sciences, Natural sciences, Technological sciences, </scie_area_en><scie_field_hr>Interdisciplinarne prirodne znanosti, Biologija, Temeljne medicinske znanosti, Kliničke medicinske znanosti, Javno zdravstvo i zdravstvena zaštita, </scie_field_hr><scie_field_en>Interdisciplinary natural sciences, Biology, Basic Medical Sciences, Clinical sciences, Public health and health services, </scie_field_en><institution_hr><![CDATA[Institut za medicinska istraživanja i medicinu rada]]></institution_hr><institution_en><![CDATA[Institute for Medical Research and Occupational Health]]></institution_en><team_members_id>171, 26291, 25971, 20288, 26003, 24075, 26314, 26281, 4035, 1223, 26280, 26216, 865031, 865628, 866664, </team_members_id><team_members_names><![CDATA[Marko Gerić, Silvije Davila, Ivana Jakovljević, Gordana Pehnec, Ante Cvitković, Mandica Sanković, Antun Šumanovac, Nancy B. Hopf, Vilena Kašuna, Mirta Milic, Guseva Canu Irina, Pascal Wild, Katarina Matković, Maja Nikolic, Luka Delić, ]]></team_members_names><keywords_hr><![CDATA[onečišćenje zraka, lebdeće čestice, biomonitoring populacija, mikronukleus test, komet test, oksidacijski stres, procjena rizika]]></keywords_hr><keywords_en><![CDATA[air pollution, particulate matter, human biomonitoring, micronucleus assay, comet assay, oxidative stress, risk assessment]]></keywords_en><summary_hr><![CDATA[Čist zrak je ključan za naše zdravlje i okoliš. Porast industrijske proizvodnje, potražnja za energijom, gorenje fosilnih goriva kao i porast prometa uvelike doprinose onečišćenju zraka u našim gradovima. Posljedično, onečišćenje zraka dovodi do ozbiljnih problema za ljudsko zdravlje i okoliš. Zrak u urbanim sredinama kompleksna je i promjenjiva mješavina raznih kemijskih spojeva čiji mehanizam djelovanja nije u potpunosti poznat, iako se sumnja na oksidacijski stres i upalne procese. Biomonitoring ljudi ključan je alat za određivanje mogu li i u kojoj mjeri okolišni spojevi utjecati na populaciju ljudi te tako pruža bitne informacije o okolišnoj izloženosti i pomaže u prepoznavanju potencijalnih zdravstvenih rizika. Stoga je cilj projekta HUMNap odrediti povezanost između onečišćivala iz zraka te biomarkera izloženosti i ranog biološkog učinka. Projekt će započeti s istraživanjima na lokacijama s različitim razinama i podrijetlom onečišćenja zraka te mjerenjima brojnih onečišćivala iz zraka. U sljedećim koracima vršit će se detaljna procjena različitih biomarkera izloženosti i ranih bioloških učinaka (genomska nestabilnost i oksidativni stres) u ljudskoj populaciji koja živi na lokacijama od interesa. HUMNap će promicati razmjenu najnovijih tehnika i istraživačkih pristupa kako bi se razvila procjena rizika izloženosti ljudi onečišćivalima iz zraka. Rezultati projekta HUMNap pokazat će kako onečišćenje zraka utječe na rane molekularne događaje važne za razvoj bolesti u različitim ljudskim stanicama. Također će pružiti procjenu rizika od raka kod populacija izloženih zagađenjima zraka u urbanim područjima. Nadalje, HUMNap nastoji privući pozornost raznih interesnih skupina kao što su vodeći znanstvenici, donositelji odluka, industrija i javnost kako bi se podigla svijest o prijetnji onečišćenog zraka i razvili režimi praćenja. Naposljetku, HUMNap će osigurati nove podatke potrebne za znanstveno utemeljenu procjenu rizika ljudske populacije izložene zagađenju zraka.]]></summary_hr><summary_en><![CDATA[Clean air is crucial to our health and the environment. Rising industrial and energy productions, the burning of fossil fuels and biomass, as well as the rise in road traffic contribute to air pollution in our cities. Hence, air pollution leads to serious health and environmental problems. Urban air is a complex and variable mixture of many different chemicals whose exact mechanisms of action is not known, although oxidative stress and inflammation are suspected. Human biomonitoring is an essential tool for assessing whether and to what extent environmental substances affect the human population and as such can provide valuable data on environmental exposure and to help identify potential health risks. Therefore, HUMNap will determine possible associations between the air pollutants and biomarkers of exposure and early biological effect. The project will start with investigations at multiple locations with different air pollution levels and origin followed by measurement of various environmental airborne pollutants. The next step will be a detailed assessment of different biomarkers of exposure and early biological effects (genomic instability and oxidative stress) in human populations living in those locations. HUMNap will promote state-of-art techniques and research approaches to develop risk assessments of human exposure to airborne pollutants. The results from HUMNap will demonstrate how airborne pollutants affect early molecular events important for disease development in different human cells. It will also provide an assessment of cancer risk among human populations affected by polluted urban areas. Moreover, HUMNap aims to draw the attention of many stakeholders such as leading scientists, policy makers, industry, and the public in order to raise awareness regarding air pollution and to develop monitoring regimes. Finally, HUMNap will provide new datasets necessary for scientifically based risk assessments of human populations exposed to urban air pollution.]]></summary_en></project><project>
<id>9780</id><title_hr><![CDATA[Procjena otpuštanja čestica mikroplastike iz poliesterskih tekstilija u procesu pranja]]></title_hr><title_en><![CDATA[Assessment of microplastic shedding from polyester textiles in washing process]]></title_en><user_id>5841</user_id><user_firstLast_name>Tanja Pušić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2020-02</proposal_call><code>IP-2020-02-7575</code><acronim><![CDATA[InWaShed-MP]]></acronim><duration>01.02.2021 - 31.01.2025</duration><status>Završio</status><financ_value>120.881,54 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Tekstilna tehnologija, </scie_field_hr><scie_field_en>Textile technology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Tekstilno-tehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Textile Technology]]></institution_en><team_members_id>23625, 789, 1494, 25962, 25951, 3887, 1481, 12361, 1466, 4810, 23609, 23301, 23300, 865199, 865353, 866609, 867579, </team_members_id><team_members_names><![CDATA[Mirjana Čurlin, Anica Hursa Šajatović, Zorana Kovačević, Branko Neral, Olivera Sauperl, Edita Vujasinović, Branka Vojnović, Kristina Šimić, Ana Budimir, Tihana Dekanić, Agata Vinčić, Nino Dimitrov, Ivona Vidić Štrac, Ana Šaravanja, Tea Kaurin Kaurin, Julija Volmajer Valh, Petra Mihovilović, ]]></team_members_names><keywords_hr><![CDATA[poliesterske tekstilije, proces pranja, postepeno hlađenje kupelji, mikroplastika, kitozan, obrada tkanine]]></keywords_hr><keywords_en><![CDATA[polyester textiles, washing process, Cool down, microplastic, chitozan, finishing]]></keywords_en><summary_hr><![CDATA[U sklopu ovog projekta provjerit će se koncept inovativnog procesa pranja i značaj obrade poliesterskih (PES) tekstilija biopolimerom kitozanom u procjeni otpuštanja MP čestica u pranju. Inovativan proces pranja uključit će postepeno hlađenje procesne kupelji gradijentnom brzinom manjom od 4°C/minuti, a obrada poliesterskih tkanina i pletiva  provest će se kitozanom. Neobrađene i kitozanom obrađene PES tekstilije prije i nakon provedbe standardnog i inovativnog procesa pranja analizirat će se fizikalno-kemijskim metodama. Dobiveni podaci zajedno sa svim rezultatima karakterizacije voda nakon pranja i ispiranja, filtrata i filtarskog kolača nakon filtracije činit će matricu podataka na osnovi koje će se provesti multivarijantna analiza podataka (MVA). Rezultati analize strukturirat će se kroz portfolio standardnog i inovativnog procesa pranja za svaku od neobrađenih i biopolimerima obrađenih poliesterskih tkanina i pletiva. Na osnovi sadržaja portfolia će se dobiti uvid u kvalitativne i kvantitativne karakteristike otpuštenih čestica, te primjenjivost pojedine metode karakterizacije.]]></summary_hr><summary_en><![CDATA[The impact of innovative washing process and the modification of polyester (PES) textiles with biopolymer chitosan on microplastic (MP) shedding will be assessed though the project plan. Innovative washing process will be designed through Cool down system with gradient lower than 4°C/min. Polyester fabrics and knits will be modified with chitosan. Unmodified and biopolymer modified fabrics and knits will be characterized by physico-chemical methods before and after standard and innovative washing process. The obtained results of polyester textiles characterization and the results of process water, filtrate and filter cake analysis will constitute a data matrix to be used in multivariate data analysis (MVA). Investigation results will be structured in a portfolio of conventional and innovative washing process for each of the untreated polyester fabrics and knits and those treated with chitosan. The portfolio content will offer insight into qualitative and quantitative characteristics of MP shedded, as well as the applicability of each individual method of characterisation. ]]></summary_en></project><project>
<id>9782</id><title_hr><![CDATA[Strojno učenje za prijenos znanja u medicinskoj radiologiji]]></title_hr><title_en><![CDATA[Machine Learning for Knowledge Transfer in Medical Radiology]]></title_en><user_id>1485</user_id><user_firstLast_name>Ivan Štajduhar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2020-02</proposal_call><code>IP-2020-02-3770</code><acronim><![CDATA[RadiologyNET]]></acronim><duration>01.01.2021 - 31.12.2024</duration><status>Završio</status><financ_value>180.157,94 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Tehnički fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Engineering]]></institution_en><team_members_id>25743, 7141, 25915, 25872, 29050, 25058, 865061, 867521, </team_members_id><team_members_names><![CDATA[Franko Hržić, Goran Glavaš, Matija Milanic, Sebastian Tschauner, Mihaela Mamula Saračević, Damir Miletić, Mateja Napravnik, Zinaid Kapić, ]]></team_members_names><keywords_hr><![CDATA[strojno učenje, duboko učenje, učenje prijenosom znanja, voluminozni podaci, analiza slike, računalom potpomognuto dijagnosticiranje, medicina ]]></keywords_hr><keywords_en><![CDATA[machine learning, deep learning, transfer learning, big data, image analysis, computer-aided diagnosis, medicine]]></keywords_en><summary_hr><![CDATA[Medicinska radiologija često se koristi u kliničkoj analizi za postavljanje medicinske dijagnoze na neinvazivan način. Razmatranjem morfoloških karakteristika promatranog područja, kliničari mogu odrediti prisutnost ozljede ili bolesti bez potrebe za provedbom invazivnog zahvata. Svrha računalno potpomognute dijagnostike (CAD) je liječnicima pružiti pomoć u interpretaciji zabilježenih podataka. U posljednje je vrijeme primjena tehnika strojnog učenja počela uzimati maha u ovom području, povećavajući točnost ručno stvorenim modelima ili ih čak u potpunosti zamjenjujući. Recentan očigledan porast primjene tih tehnika u analizi medicinskih slika omogućen je zbog šire dostupnosti podataka, povećane procesne moći računala i znantnijeg napretka ostvarenog korištenjem postupaka dubokog učenja u primjenama računalnog vida. Ovaj je razvoj pak stvorio potencijal za uvođenje značajnih promjena u biologiji i medicini, kako laboratorijskoj, tako i kliničkoj. Jedna od bitnih prednosti tehnika strojnog učenja u medicini u odnosu na tehnike filtriranja leži u njihovoj sposobnosti otkrivanja novih postupaka dijagnosticiranja bolesti, dotad nezamislivih. Dodatno, zbog kompleksnosti modeliranja stanja usko vezanog uz karakteristike pacijenta, tehnike strojnog učenja počele su uzimati maha kao bitan čimbenik u implementaciji personalizirane medicine u klinici. Predloženo istraživanje unaprijedit će postojeće znanje vezano uz modeliranje u analizi medicinskih slika uvođenjem zajedničke platforme za učenje prijenosom znanja za izgradnju preciznijih prediktivnih modela, namijenjenih automatizaciji postupaka otkrivanja bolesti i ozljeda u medicinskim CAD sustavima, što će u konačnici rezultirati poboljšanjem zdravstvene skrbi.]]></summary_hr><summary_en><![CDATA[Medical radiology is often used in clinical analysis to establish a medical diagnosis in a non-invasive manner. By considering the morphological properties of the observed area, clinicians can determine the presence of an injury or a disease without the need for invasive surgery. The purpose of computer-aided diagnosis (CAD) is to help physicians with interpreting the recorded data. Recently, the use of machine learning techniques has begun to grow rapidly in this area, increasing the accuracy of manually-crafted models, or even entirely replacing them. A recent apparent increase in the use of these techniques in medical image analysis has been facilitated due to a wider availability of data, increased computer processing power, and a more significant progress achieved through the use of deep-learning techniques in machine vision applications. This development, in turn, has created the potential for introducing significant changes to biology and medicine, both in the laboratory and in the clinic. One of the essential advantages of machine-learning techniques, in comparison to the filtering techniques, in medicine, lies in their ability to unearth new procedures for diagnosing diseases, such that have been inconceivable so far. Additionally, due to the complexity of modelling specific conditions, closely related to patient&#39;s characteristics, machine-learning techniques are increasingly becoming an essential factor in the implementation of personalized medicine in the clinic. The proposed research will advance existing knowledge concerning modelling for medical image analysis, by introducing a common transfer-learning platform for building more accurate predictive models, intended to automate disease and injury detection procedures in medical CAD systems, ultimately resulting in improved health care.]]></summary_en></project><project>
<id>9783</id><title_hr><![CDATA[Od različitosti tradicija prema zajedničkoj euromediteranskoj bioetičkoj platformi – konstrukcija alata za dijalog i djelovanje]]></title_hr><title_en><![CDATA[From diversity of traditions to a common Euro-Mediterranean bioethical platform – constructing a tool for dialogue and action]]></title_en><user_id>4099</user_id><user_firstLast_name>Amir Muzur</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2020-02</proposal_call><code>IP-2020-02-7450</code><acronim><![CDATA[EuroBioMed]]></acronim><duration>01.01.2021 - 31.12.2024</duration><status>Završio</status><financ_value>53.221,85 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Interdisciplinarne humanističke znanosti, Filozofija, Povijest, </scie_field_hr><scie_field_en>Interdisciplinary humanities, Philosophy, History, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Medicine]]></institution_en><team_members_id>26220, 6885, 5129, 23827, 5496, 23853, 5108, 5335, 23955, 29564, 861743, 865504, 865509, </team_members_id><team_members_names><![CDATA[Toni Buterin, Ivana Zagorac, Iva Rinčić, Josip Guć, Robert Doričić, Željko Kaluđerović, Igor Eterović, Tijana Trako Poljak, Marianna Gensabella, Eleni Kalokairinou, Ivana Tutić Grokša, Miltiadis Vantsos, Maria, Laura Giacobello, ]]></team_members_names><keywords_hr><![CDATA[Sredozemlje, bioetika, tradicija, stavovi, suradnja]]></keywords_hr><keywords_en><![CDATA[Mediterranean, bioethics, tradition, attitudes, collaboration]]></keywords_en><summary_hr><![CDATA[Zadnjih godina vidljiva je tendencija kontinentalnog, regionalnog, pa i nacionalnog definiranja i razvijanja bioetičkih ideja („europska bioetika“, „istočnoazijska bioetika“, „bosanska bioetika“,...), nerijetko s ciljem diferenciranja prema dominantoj i suženoj bioetičkoj paradigmi – zapravo biomedicinskoj etici – koju od 1970-ih promiče većina angloameričkih institucija. Polazeći od bliskih kulturoloških inicijativa (Španjolska, Italija), kao i nekih domaćih primjera pokušaja koncipiranja „mediteranske bioetike“, cilj je projekta analizirati sličnosti i razlike bioetičkih tradicija i njihovih razvojnih putova na europskom Sredozemlju. Teorijska analiza bit će upotpunjena empirijskim istraživanjem, s konačnim ciljem formiranja zajedničke euromediteranske bioetičke platforme. Od metoda, primjenjivat će se: kritička usporedna analiza objavljenih tekstova o povijesti bioetike u Španjolskoj, Italiji, Hrvatskoj, Grčkoj i dr.; usporedba postojećih ideja i spoznaja, kao preduvjet rasprave na načelima integrativnobioetičkog pluriperspektivizma kroz različite oblike radionica/konferencija; istraživanje stavova o „bioetičkim standardima“ (rezultat IP „Europska bioetika na djelu – EuroBioAct, HRZZ 2014.-2017., voditelj A. Muzur); kvantitatvno empirijsko istraživanje s odgovarajućim uzorkom studenata medicinskih, teoloških, pravnih i filozofskih fakulteta u Messini, Solunu, Rijeci, Zagrebu i Splitu i Barceloni; trajna otvorena metoda koordinacije; pokretanje interaktivnih mrežnih stranica s bazama podataka o sličnostima i razlikama među tradicijama, stavovima, dominantnim bioetičkim školama i projektima, čime će se uspostaviti održiv model dijaloga i djelovanja „Euromediteranske bioetičke platforme“. Očekivani rezultati: detektirane sličnosti i razlike među bioetičkim tradicijama Euromediterana, analizirani stavovi o bioetičkim standardima u odabranim zemljama Euromediterana, zajednička povelja bioetičkih standarda, interaktivna mrežna stranica s bazama podataka.]]></summary_hr><summary_en><![CDATA[For several years, a tendency is present of continental, regional, and even national defining and developing of bioethical ideas („European Bioethics,” „East-Asian Bioethics,“ „Bosnian Bioethics,“ etc.), often aiming at differentiation with respect to the dominant and narrowed-down bioethical paradigm (actually, of biomedical ethics) as promoted by the most of Anglo-American institutions since 1970s. Basing on certain initiatives in Spain, Italy, and Croatia, trying to conceive a „Mediterranean Bioethics,“ the main goal of the proposed project is to analyse similarities and differences among bioethical traditions within the Euro-Mediterranean region. The theoretical analysis will be supported by empirical research finally aiming to form a common Euro-Mediterranean platform. The following methods will be applied: critical comparative analysis of published texts on the history of bioethics in Spain, Italy, Croatia, Greece, etc.; comparison of the the existing ideas based upon the principles of the Integrative-Bioethics pluriperspectivism using different forms of workshops/conferences;surveys investigating attitudes related to „Bioethical Standards“ (the result of the research project „European Bioethics in Action – EuroBioAct,“ CSF, 2014-2017, PI A. Muzur) – a quantitative empirical research on a sample of students from medical, theological, law, and philosophical faculties in Messina, Thessaloniki, Rijeka, Zagreb, Split, and Barcelona; the continuous open method of coordination: the interactive website with databases related to similarities and differences among traditions, attitudes, thinkers, and projects, to be a sustainable model of dialogue, co-operation, and action („Euro-Mediterranean Bioethical Platform“). The expected results: the detection of similarities and differences among bioethical traditions of the Euro-Mediterranean region, a joint charter of bioethical standards, an interactive website with databases.]]></summary_en></project><project>
<id>9784</id><title_hr><![CDATA[Između bogova i ljudi - Kultovi i stanovništvo rimske Dalmacije prema zavjetnim natpisima]]></title_hr><title_en><![CDATA[Among gods and men - The cults and the population of Roman Dalmatia according to the votive inscriptions]]></title_en><user_id>3255</user_id><user_firstLast_name>Ljubica Perinić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2020-02</proposal_call><code>IP-2020-02-7214</code><acronim><![CDATA[AGM]]></acronim><duration>01.02.2021 - 15.06.2025</duration><status>Završio</status><financ_value>50.141,08 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Arheologija, Interdisciplinarne humanističke znanosti, </scie_field_hr><scie_field_en>Archeology, Interdisciplinary humanities, </scie_field_en><institution_hr><![CDATA[Hrvatska akademija znanosti i umjetnosti]]></institution_hr><institution_en><![CDATA[Croatian Academy of Sciences and Arts]]></institution_en><team_members_id>29098, 2704, 7515, 4346, 26815, 26357, 6305, 4660, 26835, 867448, </team_members_id><team_members_names><![CDATA[Amra Šačić Beća, Danijel Dzino, Dino Demicheli, Alka Domić Kunić, Saimir Shpuza, Inga Vilogorac Brčić, Kornelija Giunio A., Ivan Radman-Livaja, Nino Švonja, Tomislav Kiš, ]]></team_members_names><keywords_hr><![CDATA[Rimska religija, kultovi, zavjetni natpisi, reljefni spomenici, figuralni spomenici, stanovništvo Dalmacije, rimska provincija Dalmacija]]></keywords_hr><keywords_en><![CDATA[Roman religion, cults, votive inscriptions, relief monuments, figural monuments, population of Dalmatia, Roman province of Dalmatia]]></keywords_en><summary_hr><![CDATA[Rimska religija u provinciji Dalmaciji nikada nije proučavana sveobuhvatno. Rasprave o različitim kultovima uglavnom su bile usmjerene ili na ograničena geografska područja, ili na pojedinačne aspekte ovog složenog fenomena. U većini slučajeva oni su obuhvaćali ikonografska pitanja, manje onomastičke značajke štovatelja, a vrlo rijetko i širu društvenu pozadinu, dok su se epigrafske analize provodile povremeno, ali nikad sveobuhvatno. Unatoč razmjerno velikom broju relevantnih publikacija, još uvijek nije objavljena sistematizacija tako prikupljenog znanja. Kao rezultat toga, istraživači se suočavaju s poteškoćama u korištenju raspršenih podataka, koji nisu uvijek lako dostupni. Najvažniji doprinos predloženog istraživanja bit će u holističkom pristupu proučavanju svih zavjetnih natpisa, kao i figuralnih prikaza, s fokusom na bogovima i štovateljima. Takav pristup rezultirat će cjelovitijom i potpunijom slikom razvoja i rasprostranjenosti kultova u provinciji Dalmaciji. Krajnji cilj istraživanja je temeljito preispitivanje zavjetnih epigrafskih dokaza i njihova sistematizacija, što rezultira opsežnim uvidom u društvene aspekte vjerskih uvjerenja, tradicija i praksi te njihov utjecaj na evoluciju kulturnih identiteta. Koristeći suvremene metodologije i operativne alate, ovaj projekt će integriranu studiju religije u rimskoj Dalmaciji učiniti dostupnu široj akademskoj zajednici. To će dodatno unaprijediti naše znanje o različitim disciplinama rimskih studija (religija, prosopografija, povijest) kroz sintezu postojećih podataka s onima predviđenim kroz ovaj projektni prijedlog. Time će se popuniti praznine u sadašnjem znanju o rimskoj religiji u Dalmaciji, uzrokovane prethodnim nedostatkom sveobuhvatnog istraživanja različitih sastavnica. Planirani rezultati će stoga imati potencijal da postanu referentni za daljnje proučavanje ove teme ne samo u Dalmaciji, već uopće.]]></summary_hr><summary_en><![CDATA[Roman religion in the province of Dalmatia has never been studied comprehensively. Discussions of various cults were mostly focused either on limited geographical areas, or on individual aspects of this complex phenomenon. In most cases they comprised iconographical issues, less so onomastic characteristics of the worshippers, and very rarely their broader social background, while epigraphic analyses were conducted occasionally, but never comprehensively. In spite of a relatively large body of relevant publications, no systemization of thus compiled knowledge has yet been attempted. As a result, researchers are faced with difficulties in using dispersed data, not always readily accessible. The most important contribution of the proposed research will be in the holistic approach to the study of the entire votive epigraphic and figural evidence, focusing on both the gods and worshippers. This should result in an overall and more complete picture of the developments and distribution of cults in the province of Dalmatia. The ultimate goal of the research is a thorough reassessment of the votive epigraphic evidence and its systemization, resulting in an extensive insight into social aspects of religious beliefs, traditions and practices, and their impact on the evolution of cultural identities. By using modern methodologies and operational tools, this project will bring home an integrated study of the religion in Roman Dalmatia to the wider academic community. It will further improve our knowledge of various disciplines of Roman studies (religion, prosopography, history) through a synthesis of the existing data with those anticipated through the planned research. This will fill gaps in the present knowledge of Roman religion in Dalmatia, caused by the previous lack of all-inclusive research of its various components. The planned results will thus have a potential for becoming referential for further studies of this theme not only in Dalmatia, but generally. ]]></summary_en></project><project>
<id>9796</id><title_hr><![CDATA[Povećanje prostorne i vremenske skale modeliranja materijala iz prvih principa pomoću strojnog učenja]]></title_hr><title_en><![CDATA[Extending length and time scales of first principles material modelling via machine learning]]></title_en><user_id>24947</user_id><user_firstLast_name>Ivor Lončarić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2020-02</proposal_call><code>UIP-2020-02-5675</code><acronim><![CDATA[ExtMatModelML]]></acronim><duration>15.01.2021 - 14.01.2026</duration><status>U tijeku</status><financ_value>243.413,63 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, Kemija, </scie_field_hr><scie_field_en>Physics, Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>865204, 865259, 867384, 868096, 869780, 867427, </team_members_id><team_members_names><![CDATA[Bruno Mladineo, Raffaello Bianco, Anastasiia Kholtobina, Luka Benić, Radovan Matula, Bernhard Kretz, ]]></team_members_names><keywords_hr><![CDATA[teorija funkcionala gustoće, molekularna dinamika, strojno učenje, molekularni kristali, kataliza]]></keywords_hr><keywords_en><![CDATA[density functional theory, molecular dynamics, machine learning, molecular crystals, catalysis]]></keywords_en><summary_hr><![CDATA[Modeliranje materijala na temelju teorije funkcionala gustoće (eng. kratica DFT) danas je nezamjenjivo u istraživanju materijala. S povećanjem računalne snage i sinergijom sa znanošću o podacima, ono može postati jeftiniji i produktivniji laboratorij za otkrivanje materijala. Međutim, u slučajevima kada se proučavaju materijali s velikim brojem atoma u jediničnoj ćeliji i/ili kada je potrebna dugotrajna dinamika, DFT postaje računalno preskup. Dva primjera takvih slučajeva od visokog akademskog i gospodarskog interesa su modeliranje dinamičkih i temperaturnih efekata u molekularnim kristalima i dinamika molekula na površinama. Da bi se preciznost DFT-a spojila sa zahtjevima za dugotrajnom dinamikom s velikim brojem atoma, koristit će se strojno učenje (s umjetnim neuronskim mrežama) ploha potencijalne energije koje se temelje na prethodno izračunatim DFT energijama/silama. Takve strojno naučene plohe potencijalne energije omogućuju dobivanje energije/sile s DFT točnosti s nekoliko puta manjim računalnim troškom. Dva najvažnija znanstvena doprinosa ovog projekta bit će: i) strojno naučeni potencijali za molekularne kristale koji će omogućiti razumijevanje dinamičkih i temperaturno induciranih pojava u molekularnim kristalima (kao istaknuti primjer bit će objašnjen tzv. termoodskočni fenomen), te visoko propusno probiranje molekularnih kristala s poželjnim svojstvima, ii) razumijevanje složene dinamike molekula na površinama relevantnim za heterogenu katalizu pod različitim uvjetima pobude, pokrivenosti i tlaka kroz molekularnu dinamiku na strojno naučenim potencijalima. Krajnji cilj ovog projekta je uspostaviti grupu koja bi svojim znanjem DFT-a osnaženim tehnikama strojnog učenja, kroz suradnju s eksperimentalnim istraživanjima i edukacijom mladih istraživača, značajno unaprijedila istraživanje materijala u Hrvatskoj.]]></summary_hr><summary_en><![CDATA[Material modelling based on density functional theory (DFT) nowadays is an indispensable tool in materials research. With increasing computational power and with the advent of data science techniques it could become cheaper and more productive materials discovery laboratory. However, in cases where materials with a large number of atoms in the unit cell are studied and/or when long time dynamics is needed, DFT becomes computationally too expensive. Two examples of such cases of high academic and economic interest are modelling temperature effects in molecular crystals and dynamics of molecules on surfaces. To bridge accuracy of DFT with requirements for long time dynamics with a large number of atoms, machine learning (with artificial neural networks) of potential energy surfaces based on precomputed DFT energies/forces will be employed. Such machine-learned potential energy surfaces enable evaluation of energy/forces with DFT accuracy at a fraction of computational cost. The two most important scientific contributions of this project will be: i) machine learned potentials for molecular crystals that will enable understanding of dynamical and temperature induced phenomena in molecular crystals (as a prominent example a thermosalient effect will be explained), and high-throughput screening of molecular crystals for desirable properties, ii) understanding complex dynamics of molecules on surfaces relevant for heterogeneous catalysis under different excitation, coverage, and pressure conditions through molecular dynamics on machine learned potentials. The ultimate aim of this project is to establish a group that would, with its expertise in DFT reinforced with machine learning techniques, through collaboration with experimentalists, and by educating young researchers, significantly enhance materials research in Croatia.]]></summary_en></project><project>
<id>9797</id><title_hr><![CDATA[SIMON: Inteligentni sustav za automatsku slelekciju algoritama strojnog učenja u društvenim znanostima]]></title_hr><title_en><![CDATA[SIMON: Intelligent system for automatic selection of machine learning algorithms in social sciences]]></title_en><user_id>12549</user_id><user_firstLast_name>Dijana Oreški</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2020-02</proposal_call><code>UIP-2020-02-6312</code><acronim><![CDATA[SIMON]]></acronim><duration>01.05.2021 - 30.04.2026</duration><status>U tijeku</status><financ_value>144.999,67 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Informacijske znanosti, Interdisciplinarne društvene znanosti, </scie_field_hr><scie_field_en>Information sciences, Interdisciplinary social sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet organizacije i informatike]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Organization and Informatics]]></institution_en><team_members_id>29539, 29337, 12805, 12521, 13136, 25684, 25701, 5913, 865279, 869919, </team_members_id><team_members_names><![CDATA[Milica Maričić, Maja Rožman, Igor Pihir, Nikola Kadoić, Goran Hajdin, Irena  Kedmenec, Marko Domladovac, Maja Gligora Marković, Dunja Višnjić, Marija Pokos Lukinec, ]]></team_members_names><keywords_hr><![CDATA[Strojno učenje, podatkovna znanost, meta učenje, obrazovanje, poslovanje]]></keywords_hr><keywords_en><![CDATA[Machine learning, data science, meta learning, education, business]]></keywords_en><summary_hr><![CDATA[Sposobnost generiranja podataka nikada nije bila tako snažna kao danas kada se dnevno stvara tri kvintilijuna bajtova podataka. U području strojnog učenja razvijen je velik broj algoritama koji se mogu koristiti za inteligentnu analizu podataka i rješavanje problema predviđanja i deskripcije u različitim domenama. Razvijeni algoritmi imaju različite učinke na različitim problemima. Ako jedan algoritam radi bolje na jednom skupu podataka, isti algoritam može raditi lošije na drugom skupu podataka. Razlog tome je što svaki skup podataka ima različite značajke. Stoga je imperativ današnjih istraživanja povezati intrinzična ponašanja algoritama s različitim značajkama skupova podataka i pronaći pravi algoritam za problem koji se rješava. S tim ciljem predloženi prijedlog istraživanja daje znanstveni doprinos u području meta učenja identificirajuće specifične značajke skupova podataka u dvije domene društvenih znanosti: obrazovanju i poslovanju te razvija metamodele koji se temelje na: rangiranju algoritama, izračunu povezanosti rangova, izradi višekriterijskog modela, dvokomponentnog indeksa i predkciji ishoda temeljem algoritama strojnog učenja. Svaki od metamodela služi kao temelj za izradu inačice inteligentnog sustava. Krajnji ishod projekta je inteligentni sustav za automatski odabir algoritma strojnog učenja koje će dati nabolje performanse na određenom skupu podataka uzimajući u obzir specifične značajke tog skupa. Istraživanje uključuje komparativnu analizu velikog broja algoritama strojnog učenja na velikom broju skupova podataka.]]></summary_hr><summary_en><![CDATA[The ability to generate data has never been as powerful as today when three quintile bytes of data are generated daily. In the field of machine learning, a large number of algorithms have been developed, which can be used for intelligent data analysis and to solve prediction and descriptive problems in different domains. Developed algorithms have different effects on different problems. If one algorithms works better on one dataset, the same algorithm may work worse on another data set. The reason is that each dataset has different features in terms of local and global characteristics. It is therefore imperative to know intrinsic algorithms behavior on different types of datasets and choose the right algorithm for the problem solving. To address this problem, this project gives scientific contribution in meta learning field by identifying the specific characteristics of datasets in two domains of social sciences: education and business and develops meta models based on: ranking algorithms, calculating correlation of ranks, developing a multi-criteria model, two-component index and prediction based on machine learning algorithms. Each of the meta models serve as the basis for the development of intelligent system version. The end result of the project is an intelligent system for automatic selection of machine learning algorithm that will give better performance to a given dataset, taking into account the specific characteristics of data. The research involves a comparative analysis of a large number of machine learning algorithms on a large number of datasets.]]></summary_en></project><project>
<id>9798</id><title_hr><![CDATA[Raščlamba determinanti kvalitete financijskog izvještavanja]]></title_hr><title_en><![CDATA[Disentangling Financial Reporting Quality]]></title_en><user_id>29341</user_id><user_firstLast_name>Željana Aljinović Barać</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2020-02</proposal_call><code>IP-2020-02-9372</code><acronim><![CDATA[DISFRQ]]></acronim><duration>01.01.2021 - 31.12.2024</duration><status>Završio</status><financ_value>38.553,32 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, </scie_field_hr><scie_field_en>Economy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Ekonomski fakultet]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Economics, Business and Tourism]]></institution_en><team_members_id>29350, 29349, 29415, 29503, 866728, </team_members_id><team_members_names><![CDATA[Tina Vuko, Slavko Šodan, Andrijana Rogošić, Clive Lennox, Ivana Perica, ]]></team_members_names><keywords_hr><![CDATA[kvaliteta financijskog izvještavanja, kvaliteta revizije, revizijske korekcije, efekt Velike četvorke, Kodeks etike ]]></keywords_hr><keywords_en><![CDATA[financial reporting quality, audit quality, year-end audit adjustments, Big 4 audit effect, Code of Ethics]]></keywords_en><summary_hr><![CDATA[Kvaliteta financijskog izvještavanja (engl. Financial Reporting Quality, skr. FRQ) predstavlja uvijek aktualno pitanje koje postaje posebno relevantno u razdobljima financijske nestabilnosti i korporativnih skandala (npr. Agrokor u Hrvatskoj). FRQ je funkcija kvalitete nerevidiranih financijskih izvještaja i kvalitete revizije. S obzirom da nerevidirani financijski izvještaji nisu javno dostupni u većini zemalja, dosadašnja empirijska istraživanja nisu mogla razdvojiti FRQ od kvalitete revizije. Zbog toga se obično mjere kvalitete revizije i mjere FRQ operacionaliziraju na isti način i temelje na istom setu podataka - iz revidiranih financijskih izvještaja. Budući da listana društva u Hrvatskoj objavljuju i nerevidirane i revidirane godišnje financijske izvještaje, pruža se jedinstvena prilika za procjenu kvalitete revizije usporedbom različitih mjera FRQ na podatcima iz nerevidiranih i revidiranih financijskih izvještaja. Također, specifičnosti predloženog istraživačkog okvira omogućavaju uparivanje klijenata revizora iz skupina Velika četvorka i ostali revizori prema kvaliteti nerevidiranih izvještaja. Time će se utvrditi jesu li razlike u kvaliteti revidiranih financijskih izvještaja uistinu rezultat efekta Velike četvorke. Konačno, budući da kvaliteta financijskog izvještavanja može biti ugrožena namjernim i nenamjernim pogrešnim prikazivanjem pozicija u financijskim izvještajima, važno je utvrditi ima li etika učinak na financijsko izvještavanje. Sukladno navedenom, predmetno istraživanje obuhvaća tri glavna cilja: 1) utvrditi jesu li i kako mjere FRQ poboljšane tijekom procesa revizije; 2) analizirati odnos između kvalitete nerevidiranih financijskih izvještaja i odabira revizora kako bi se utvrdilo pruža li doista Velika četvorka veću kvalitetu revizije u odnosu na ostale revizore; te 3) odrediti razinu upoznatosti računovođa s Kodeksom etike za profesionalne računovođe i utjecaj istog na FRQ.]]></summary_hr><summary_en><![CDATA[Different high-profile corporate scandals in Croatia (e.g. Agrokor case) and worldwide have highlighted the critical importance of credible, high quality financial reporting system. Financial reporting quality (FRQ) is a function of preaudit financial statements quality and audit quality. The problem for empirical research is that FRQ and audit quality are often inseparable in terms of observable financial reporting outcomes. Namely, preaudit financial statements are not publicly available in almost all countries, so researchers are limited to proxy both audit quality and FRQ with quality measures based only on audited financial statements. Since Croatian capital market issuers provide both audited and preudit annual financial reports, we have a unique opportunity to directly assess audit quality by disentangling and comparing the quality measures of preaudit and audited financial statements. This research setting also allows us to empirically validate commonly used proxy measure of audit quality (i.e. Big 4 auditors vs non-Big 4 auditors). Finally, since FRQ can be deteriorated by either intentional or unintentional financial reporting misstatements, it is important to determine the effect of ethics on FRQ. Accordingly, our research has three main objectives: 1) to determine whether and how the FRQ measures are improved during the process of financial statement audit; 2) to analyse the relation between the levels of preaudit FRQ and auditor selection in order to find out whether Big 4 auditors actually provide higher audit quality than non-Big 4; and 3) to determine the level of accountants’ conversance with the International Federation of Accountants (IFAC) Code of Ethics for Professional Accountants and its effect on FRQ.]]></summary_en></project><project>
<id>9799</id><title_hr><![CDATA[Prirodni bioaktivni spojevi kao izvor potencijalnih antimikrobnih tvari u suzbijanju bakterijskih i drugih gljivičnih patogena masline]]></title_hr><title_en><![CDATA[Natural bioactive compounds as a source of potential antimicrobial agents in the control of bacterial and other fungal pathogens of olives]]></title_en><user_id>18945</user_id><user_firstLast_name>Sara Godena</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2020-02</proposal_call><code>UIP-2020-02-7413</code><acronim><![CDATA[Anti-Mikrobi-OL]]></acronim><duration>01.01.2021 - 30.06.2026</duration><status>U tijeku</status><financ_value>265.432,34 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, Prehrambena tehnologija, </scie_field_hr><scie_field_en>Agriculture, Food technology, </scie_field_en><institution_hr><![CDATA[Institut za poljoprivredu i turizam]]></institution_hr><institution_en><![CDATA[Institute of Agriculture and Tourism in Poreč]]></institution_en><team_members_id>29031, 28976, 864913, 865016, 866803, 867326, 869934, 871679, </team_members_id><team_members_names><![CDATA[Janja Lamovšek, Iva Prgomet, Laura Košćak, Elena Petrović, Marwa Moumni, Mladen Zovko, Mihaela Medved, IVANA DMINIĆ ROJNIĆ, ]]></team_members_names><keywords_hr><![CDATA[antimikrobno djelovanje, biljna voda, eterična ulja, Olea europaea L., Pseudomonas savastanoi pv. savastanoi, test patogenosti]]></keywords_hr><keywords_en><![CDATA[antimicrobial activity, vegetable water, essential oils, Olea europaea L., Pseudomonas savastanoi pv. savastanoi, pathogenicity test]]></keywords_en><summary_hr><![CDATA[U istraživanju će se na području Hrvatske, Slovenije, Bosne i Hercegovine te Portugala utvrditi prisutnost bakterijskog raka i manje poznatih patogenih gljiva masline. Nakon identifikacije patogena molekularnim metodama, provesti će se test patogenosti. Budući da nema podataka o osjetljivosti hrvatskih sorti masline na rak masline, utvrditi one sorte koje su rezistentnije. Utvrditi će se i antimikrobno djelovanje kompleksnih bioaktivnih sastojaka u sastavu biljne vode i eteričnih ulja visoke kakvoće. Ispitati će se inhibicija rasta mikroorganizama in vitro i in vivo, a utvrditi će se kemijski profil za mikrobiološki aktivne sekundarne metabolite. Važnost ovog istraživanja ogledati će se kroz moguće rješenje fitopatološkog problema: budući da ne postoji adekvatna kurativa, javlja se nužnost za pronalaskom alternativnih i djelotvornih spojeva. Istraživanja o takvim spojevima nisu izrazito zastupljena iako prema literaturi postoje više od 1 340 biljaka koje su potencijalni izvor ovih spojeva. Ovi djelotvorni i neopasni spojevi predstavljaju potencijalno rješenje za problematiku u fitomedicini, odgovor su na sve ugroženije zdravlje ljudi i mogle bi smanjiti primjenu toksičnih sintetičkih pesticida. Ovim se projektom želi nastaviti daljnji rad prijašnjih istraživanja, gdje je dokazano povećanje sadržaja ukupnih fenola u zaraženim maslinama i gdje su utvrđene neke manje poznate patogene gljive. Očekuje se da će bioaktivne tvari imati velik antimikrobni učinak, da će se pronaći i način njihove primjene, a primjenom bi se tih tvari mogao riješiti i problem ekološkog zbrinjavanja biljne vode, koja nastaje kao nusproizvod i kao takva predstavlja ekološki problem. Očekuje se rast interesa za tim spojevima, a kako bi se procijenile potencijalne doze i način aplikacije, potrebna su daljnja i uzastopna istraživanja.]]></summary_hr><summary_en><![CDATA[The study will determine the presence of olive knot and less known pathogenic fungi of olive in Croatia, Slovenia, Bosnia and Herzegovina and Portugal. After confirmation of pathogen identification by molecular methods, a pathogenicity test will be performed. Since there is no information on the susceptibility of Croatian varieties to olive knot, varieties which are more resistant will be determined. Antimicrobial activity of complex bioactive constituents in the composition of vegetable water (OMWW) and high quality essential oils will be determined. The inhibition of growth of microorganisms in vitro and in vivo will be tested and the chemical profile of the microbiologically active secondary metabolites will be determined. The importance of this research will be reflected in a possible solution of phytopathological problem: since there is no adequate cure, there is a need to find alternative and effective compounds. Studies of such compounds are not pronouncedly represented in scientific databases, although there are more than 1340 plants as potential source of such compounds. These effective and non-hazardous compounds represent a potential solution to the phytomedicine problem, are an answer to the increasingly threatened human health and could reduce the use of toxic synthetic pesticides. This project aims to continue further work of previous research, where an increase in the content of total phenols in infected olives has been demonstrated, and where some less known pathogenic fungi have been identified. It is expected that bioactive substances will have a great antimicrobial effect, that method of their application will be found and that their use could also solve the problem of ecological disposal of OMWW, which originated as a by-product and presents an environmental problem as such. It is expected to increase the interest in these compounds, and to evaluate potential doses and mode of application further and sequential studies are needed.]]></summary_en></project><project>
<id>9802</id><title_hr><![CDATA[Okolišni čimbenici i mikrobiološke interakcije u strukturi dentalnog biofilma]]></title_hr><title_en><![CDATA[Environmental factors and microbial interactions in the structure of the dental biofilm]]></title_en><user_id>77</user_id><user_firstLast_name>Stjepan Špalj</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2020-02</proposal_call><code>IP-2020-02-4027</code><acronim><![CDATA[DENTALBIOFILM]]></acronim><duration>22.02.2021 - 21.06.2025</duration><status>Završio</status><financ_value>198.287,88 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Dentalna medicina, </scie_field_hr><scie_field_en>Dental medicine, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Medicine]]></institution_en><team_members_id>29072, 25209, 104, 4005, 26681, 3866, 5125, 4320, 4016, 864854, 864862, 864855, 864853, 866626, 869520, </team_members_id><team_members_names><![CDATA[Martina  Drevenšek, Martina Žigante, Magda Trinajstić Zrinski, Ivana Mišković, Bojana Mohar Vitezić, Jelena Prpić, Andrej Pavlić, Davor Kuiš, Irena  Glažar, Ella Sever, Aleksandar Pupovac, Elvis Božac, Tihana Zibar Belašić, MATEA BADNJEVIĆ, Matea Tomljanovic, ]]></team_members_names><keywords_hr><![CDATA[microbiom, mikrobiota, biofilm, dental, parodont]]></keywords_hr><keywords_en><![CDATA[microbiome, microbiota, biofilm, dental, periodontium]]></keywords_en><summary_hr><![CDATA[Okolišni čimbenici povezani sa suvremenim načinom života mogu utjecati na promjene u odnosima članova oralnog mikrobioma poput medicinskih pripravaka i ugradbenih materijala, konzumacije gaziranih napitaka i duhana. Narušavanje ravnoteže mikrobioma može rezultirati nastankom oralnih infekcija te otežavati liječenje. Istraživanje je kombinacija kliničkog i in vitro pokusa, fokus je na mikrobiološkom profilu dentalnog biofilma. Istražit će se okolišni utjecaji na mikrobiom: duhan (izgaranjem duhana u klasičnim cigaretama i sustavima grijanja duhana bez izgaranja) i metali otpušteni korozijom slitina za oralnu uporabu (nikal i titan) te koliko okolišni utjecaji modificiraju djelotvornost terapije parodontnih bolesti (gingivitisa i parodontitisa) mehaničkim uklanjanjem biofilma te biocidom (klorheksidin). Radi se o novim zdravstvenim rizicima. Fokus je stavljen rane i kasne kolonizatore površine zube. Procijenit će se i stanje parodontnih tkiva, a rezultati će pokazati specifičnosti biofilma i parodontnih tkiva eksponiranih i neeksponiranih te razlike u odgovoru pojedinih bakterija na terapiju. Pomoću lančane reakcije polimeraze (real time PCR) kvantificirat će se ukupna biomasa bakterija (16s rRNK) te udio specifičnih bakterijskih vrsta unutar dentalnog biofilma. Amplificirat će se sedam varijabilnih regija 16s rRNK gena te sekvencirati pomoću tehnologije sekvencioniranja sljedeće generacije (NGS). U in vitro pokusu analizirat će se krivulje rasta pojedinih bakterija, minimalne inhibitorne koncentracije, osjetljivost na biocid, sposobnost adhezije, sposobnost stvaranja biofilma te uspješnost razaranja biofilma biocidom. Istraživanje će omogućiti uvođenje detaljne i visokospecifične analize mikrobioma u klinički rad što vodi razvoju personalizirane medicine.]]></summary_hr><summary_en><![CDATA[Environmental factors associated with modern lifestyle, such as medical devices and implant materials, consumption of carbonated beverages and tobacco could introduce changes in the relationship between members of the oral microbiome. Impaired microbiome balance can result in oral infections and complicate treatment. The study is a combination of clinical and in vitro experiments, focusing on the microbial profile of dental biofilm. Environmental impacts on the microbiome will be investigated: tobacco (tobacco combustion in conventional cigarettes and tobacco heating systems without combustion) and metals released by corrosion of alloys for oral use (nickel and titanium). Treatment of periodontal diseases (gingivitis and periodontitis) consists of mechanical removal of biofilm and the use of biocide (chlorhexidine). An alteration of the effectiveness of this treatment that may be caused by the aforementioned environmental influences will also be explored. These are new health risks. The focus is placed on early and late colonizers of the tooth surface. The status of periodontal tissues will be also evaluated, and the results will show the specificities of biofilm and periodontal tissues (exposed and unexposed) and differences in the response of individual bacteria to therapy. The polymerase chain reaction (real time PCR) will quantify the total bacterial biomass (16s rRNA) and the proportion of specific bacterial species within the dental biofilm. Seven variable regions of the 16s rRNA gene will be amplified and sequenced using Next Generation Sequencing Technology (NGS). The in vitro experiment will analyze growth curves of specific bacteria, minimal inhibitory concentrations, susceptibility to biocide, adhesion ability, biofilm formation ability and biofilm destruction by biocide. The research will enable the introduction of a detailed and highly specific microbiome analysis into clinical work facilitating personalized medicine.]]></summary_en></project><project>
<id>9809</id><title_hr><![CDATA[Obnova timusa za preciznu medicinu u liječenju tumora i leukemija]]></title_hr><title_en><![CDATA[Thymus renewal for precision medicine in cancer and leukaemia treatment]]></title_en><user_id>498</user_id><user_firstLast_name>Mariastefania Antica</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2020-02</proposal_call><code>IP-2020-02-2431</code><acronim><![CDATA[THYMINNOVA]]></acronim><duration>22.03.2021 - 21.03.2025</duration><status>Završio</status><financ_value>199.084,21 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Clinical sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>25071, 23528, 21280, 579, 12941, 24341, 865020, 865014, 3576, 3075, 867403, 869863, 868738, </team_members_id><team_members_names><![CDATA[Darko Heckel, Delfa Radić-Kristo, Domenico Vittorio Delfino, Sanja Novak, Anita Škrtić, Isabella Screpanti, Ildiko Bodi, Dražen Belina, Maja Matulić, Danka Grčević, Maria Pia Felli, Marko Skelin, Ena Vrček, ]]></team_members_names><keywords_hr><![CDATA[Timus, matične stanice iz zrelog tkiva, limfociti T, organoidi, trodimenzionalne (3D)  kulture stanica, regeneracija, precizna medicina , ]]></keywords_hr><keywords_en><![CDATA[Thymus, Adult stem cells, T lymphocytes, Organoids, 3D cultures, Regeneration, Precise Medicine]]></keywords_en><summary_hr><![CDATA[U posljednjem desetljeću ubrzano se razvijaju novi, precizni medicinski postupci za liječenje leukemija i tumora.  Navedeni postupci se temelje na stanicama imunosnog sustava, T limfocitima, kao ključnim elementima moderne imunoterapije. Osnovni organ za diferencijaciju i selekciju limfocita T je timus, gdje nastaje cijela raznovrsnost adaptivnog imunosnog sustava. Timus osigurava stromalni mikrookoliš za bliske međuakcije limfocita s molekulama koje izražavaju epitelne, endotelne i dendritske stanice. Međutim, funkcionalna sposobnost timusa se pogoršava sa starenjem i on je prvi organ čija se funkcija počinje smanjivati već u pubertetu. Timus je također vrlo podložan šteti koja nastaje zračenjem ili kemoterapijom, te kortikosteroidima uzrokovanim stresom. Obnova timusa u ljudi kod kojih je timus oštećen zbog utjecaja lijekova, stressa ili prirodnim starenjem u žarištu je predloženog istraživanja. Glavni cilj predloženog projekta je obnova i rekonstitucija timusne funkcije u in vitro uvjetima iz epitelnih matičnih stanica s težištem na sazrijevanju, diferencijaciji i razvoju imunokompetentnih limfocita T. Istraživanja se baziraju na našem nedavnom otkriću nove populacije matičnih stanica iz postnatalnog humanog timusa koja u specifičnim uvjetima 3D kultura, se može razviti u timusne epitelne stanice (TES) i stvoriti organoide. Osim ovog glavnog cilja u predloženom projektu bavit ćemo se aspektima temeljenim na novim nanomaterialima koji pridonose uspješnoj obnovi timusa ljudi te mogućnostima ex vivo testiranja novih preciznih lijekova. Interdisciplinarni tim znanstvenika će s različitim alatima i pristupima, radit na obnovi imunosnog sustava i kliničkim potrebama velike grupe pacijenata s leukemijama i tumorima, kao i u populacije s iatrogenom i dobno ovisnom smanjenom funkcijom timusa.]]></summary_hr><summary_en><![CDATA[New precise medical treatments for leukemia and cancer are emerging in the last decade. They are based on immune system cells, T lymphocytes, as key elements of modern immunotherapy. The primary organ for T lymphocyte differentiation and selection is the thymus where adaptive immune diversity is created. It provides a stromal microenvironment for close interactions of T cells with molecules expressed by epithelial, endothelial and dendritic cells. However, thymus fitness deteriorates with age and it is the first organ whose function starts to decline already at puberty. It is also very susceptible to damage caused by irradiation, corticosteroids or chemotherapy so thymus function renewal is the major focus of the proposed project. Reconstitution of thymus function in vitro from epithelial stem cells in terms of maturation, differentiation, and development of immunocompetent T lymphocytes will be performed. The objectives are based on our recent discovery of a new stem cell population from the postnatal human thymus which is able to produce thymus epithelial cells (TEC) and organoids in vitro. Besides this general goal technological, immunological and material science aspects of T lymphocyte development, thymus cultures for ex vivo drug testing will be addressed in the course of the project. These objectives are addressed by our interdisciplinary team of scientists aimed at new unmet clinical needs of large patient groups identified as leukemia patients and the population with iatrogenic or aging based decreased thymic function.]]></summary_en></project><project>
<id>9813</id><title_hr><![CDATA[Kopno ili more: ekološki i genetički aspekti izbora staništa crvenokljune čigre]]></title_hr><title_en><![CDATA[Land or sea: ecological and genetic aspects of habitat choice in the Common Tern]]></title_en><user_id>972</user_id><user_firstLast_name>Jelena Kralj</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2020-02</proposal_call><code>IP-2020-02-8793</code><acronim><![CDATA[KiM: ČIGRE]]></acronim><duration>01.02.2021 - 31.01.2025</duration><status>Završio</status><financ_value>199.017,85 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Hrvatska akademija znanosti i umjetnosti]]></institution_hr><institution_en><![CDATA[Croatian Academy of Sciences and Arts]]></institution_en><team_members_id>6172, 1110, 19944, 29466, 4008, 3784, 6141, 4597, 25638, 865212, 25601, </team_members_id><team_members_names><![CDATA[Ana Galov, Luka Jurinović, Elena Bužan, Astrid Vik Stronen, Davor Ćiković, Sanja Barišić, Haidi Arbanasić, Vesna Tutiš, Tomica Rubinić, Veronika Lončar, Željko Pavlinec, ]]></team_members_names><keywords_hr><![CDATA[morske ptice, izbor staništa, genska varijabilnost, MHC ptica, antropogeni utjecaj]]></keywords_hr><keywords_en><![CDATA[seabirds, habitat choice, genetic variability, avian MHC, anthropogenic impact]]></keywords_en><summary_hr><![CDATA[Crvenokljuna čigra Sterna hirundo je kolonijalna vrsta ptice koja se većinom gnijezdi na niskim morskim obalama, ali nastanjuje i slatkovodna kontinentalna staništa. Selica je te zime provodi duž morskih obala južne polutke. Morska staništa čigrama pružaju stabilno mjesto za gniježđenje s većim područjem hranjenja, no na moru su prisiljene trošiti energiju na izlučivanje soli, a slanoća vode ima i imunosupresivno djelovanje. Slatkovodna staništa, iako površinom manja, imaju i postojaniju dostupnost plijena, pa su pogodnija za gniježđenje. No, većina kontinentalnih kolonija zbog antropogenih pritisaka danas ovisi o umjetnim otocima i platformama, koje je neprestano potrebno održavati.Cilj ovog projekta je utvrditi razlike u uspješnosti gniježđenja, genetičkoj raznolikosti i fitnesu, kvaliteti područja gniježđenja za hranjenje odraslih te utjecaja negnijezdećeg razdoblja između morskih i kontinentalnih kolonija crvenokljune čigre.Projekt će trajati 48 mjeseci i obuhvatiti četiri gnijezdeće sezone. Terenski će se rad odvijati na kolonijama duž rijeke Save u Zagrebačkoj županiji i na sjevernom Jadranu. Kretanje prilikom hranjenja istraživat ćemo pomoću GPS-UHF odašiljača, selidbu pomoću geolokatora, a uspješnost gniježđenja praćenjem veličine pologa i produktivnosti kolonije. Neutralnu genetičku raznolikost i strukturu populacija istražit ćemo pomoću kontrolne regije mtDNA  i mikrosatelitnih lokusa, dok ćemo adaptivnu genetičku varijaciju istražiti karakterizacijom i genotipizacijom MHC lokusa pomoću NGS amplikon sekvenciranja.Otkrivanje odnosa između staništa i uspješnosti gniježđenja, fitnesa i genetičke raznolikosti crvenokljunih čigri omogućit će procjenu njihove sposobnosti prilagođavanja antropogenim promjenama u staništu. Projekt će rezultirati s četiri znanstvena rada, i 8 prezentacija na četiri međunarodne znanstvene konferencije. Dva mlada istraživača razvit će znanstvene karijere kroz ovaj projekt.]]></summary_hr><summary_en><![CDATA[The Common Tern Sterna hirundo is a colonial bird species which mostly breeds on low-lying marine coasts, but it also inhabits freshwater inland habitats. It is migratory, wintering along sea coasts of the Southern Hemisphere. Marine habitats offer terns a stable breeding place with a larger feeding area, but on the sea they are forced to invest energy into excreting salt, and salinity itself has immunosuppressive effects. Freshwater habitats, although smaller in area, also have more consistent prey availability, so they are preferable for breeding. However, because of anthropogenic habitat pressure, most inland colonies now depend on artificial islands and rafts, which require continuous management.The goal of this project is to determine differences between marine and inland Common Tern colonies in breeding performance, genetic variability and fitness, quality of breeding area for adult foraging and carry-over effects of the non-breeding period. The project will last 48 months and encompass four breeding seasons. Field work will be conducted on colonies along the river Sava in Zagreb County and in the northern Adriatic. Foraging movements will be studied with GPS-UHF technology, migration by geolocators and breeding performance through clutch size and colony productivity. Neutral genetic diversity and population structure will be studied through mtDNA control region and microsatellite loci, and adaptive genetic variation through characterization and genotyping of MHC loci by NGS amplicon sequencing.Discovering the relationship between habitat and Common Tern breeding performance, fitness and genetic diversity will enable us to assess their ability to adapt to anthropogenic changes in their habitat. Project will result in four scientific articles and eight presentations at  four international scientific conferences. Project will also enable developing scientific careers for two young researchers. ]]></summary_en></project><project>
<id>9815</id><title_hr><![CDATA[Analiza sustava u krizi i nove svijesti u književnosti 21. stoljeća]]></title_hr><title_en><![CDATA[Analysis of Systems in Crisis and of New Consciousness in 21st Century Literature]]></title_en><user_id>29129</user_id><user_firstLast_name>Sonja Novak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2020-02</proposal_call><code>UIP-2020-02-3695</code><acronim><![CDATA[ASKiNS21]]></acronim><duration>01.02.2021 - 31.01.2026</duration><status>U tijeku</status><financ_value>171.655,88 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filologija, </scie_field_hr><scie_field_en>Philology, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>29210, 29199, 864962, 865091, 26648, 11183, 870030, </team_members_id><team_members_names><![CDATA[Marijana Jeleč, Katarina  Žeravica, Iris Spajić, Marijana Mandić, Ljiljana Pintarić, Igor Gajin, Philipp Schlueter, ]]></team_members_names><keywords_hr><![CDATA[sustav, mikro, makro, kriza, književnost, 21. stoljeće]]></keywords_hr><keywords_en><![CDATA[system, micro, macro, crisis, literature, 21st century,]]></keywords_en><summary_hr><![CDATA[Projekt polazi od hipoteze kako suvremena književnost (2000.-2020. godine) ima dominantno subverzivan odnos prema različitim sociokulturološkim sustavima kao što su obitelj, lokalna zajednica (npr. grad), država, regija (npr. Balkan, EU, Bliski Istok) i okoliš/planet te da se u suvremenim književnim tekstovima pri prikazivanju tih sustava vrlo često pojavljuju različite vrste krize, kako latentne, tako i manifestne. Ciljevi istraživanja su definirati korpus književnih djela nastalih u gorenavedenom periodu na njemačkom, engleskom i hrvatskom jeziku, usustaviti metodologiju njihove analize, i to transgenerički s obzirom na vrstu/podvrstu teksta, prostor i vrijeme radnje, karakterizaciju likova, mitski/utopijski ili distopijski potencijal, mehanizme prevladavanja krize, motivaciju radnje i analizu diskursa, uspostaviti bazu podataka vezanu uz korpus potpomognuto alatima za kvalitativnu analizu sadržaja te naposljetku testirati metodologiju na odabranim suvremenim tekstovima iz korpusa. ]]></summary_hr><summary_en><![CDATA[The hypothesis of the project is that contemporary literature (published 2000- until today)  predominantly exhibits a subversive attitude towards different sociocultural systems, such as e.g. family, local community (city or settlement), state, region (the EU, the Balkans, Middle East) and the environment/planet and that contemporary literary texts when depicting these systems often show them in a state of a latent or manifested crisis. The objectives of this research project are to  define a corpus of literary texts published in the 21st century in English, German and Croatian language, to systematize a transgeneric methodology for the analysis of these texts, with special emphasis on genre/sub genre, space, time, characterization, mythic, utopian or dystopian potential, coping mechanisms, motivating agents for the plot and discourse analysis. Another objective is to establish a database about the corpus of literary texts aided by tools for qualitative content analysis and to test this methodology on a number of selected contemporary literary texts.]]></summary_en></project><project>
<id>9820</id><title_hr><![CDATA[Primjena ionizirajućeg zračenja za dobivanje polimernih  nano prevlaka na metalima]]></title_hr><title_en><![CDATA[Irradiated Polymer Nano-Coatings for Metal Protection]]></title_en><user_id>19699</user_id><user_firstLast_name>Katarina Marusic</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2020-02</proposal_call><code>IP-2020-02-4344</code><acronim><![CDATA[RadMeNano]]></acronim><duration>01.02.2021 - 30.04.2025</duration><status>Završio</status><financ_value>169.540,12 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, Fizika, Interdisciplinarne prirodne znanosti, </scie_field_hr><scie_field_en>Chemistry, Physics, Interdisciplinary natural sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>725, 212, 23721, 5803, 5203, 865234, 922, 867449, </team_members_id><team_members_names><![CDATA[Branka Mihaljević, Irina Pucić, Vladan Desnica, Domagoj Šatović, Helena Otmačić Ćurković, Ena Pezić, Damir Kralj, Helena Bach-Rojecky, ]]></team_members_names><keywords_hr><![CDATA[umrežavanje zračenjem, ionizirajuće zračenje, polimerne nano prevlake, zaštita metala, masne kiseline]]></keywords_hr><keywords_en><![CDATA[radiation crosslinking, ionising irradiation, polymer nano coatings, metal protection, fatty acids]]></keywords_en><summary_hr><![CDATA[Radijacijsko umrežavanje odnosi se na postupak u kojem se ionizirajuće zračenje gama zrakama ili brzim elektronima koristi za poticanje brzih kemijskih reakcija koje rezultiraju stvaranjem 3D mreža. Ionizirajuće zračenje je homogeno, brzo i ne uključuje upotrebu toksičnih kemikalija te se stoga smatra ekološki prihvatljivim. Umrežavanje učvršćuje prevlake, smanjuje prodor vanjskih molekula, poboljšava mehaničku čvrstoću i kemijsku otpornost, kao i druga funkcionalna svojstva, čineći takve premaze otpornijima i značajno produžujući njihov vijek trajanja.Prikladan način za dobivanje kompaktne, besprijekorne prevlake nanometarske debljine je formiranje tankih samoorganiziranih molekularnih slojeva (SAM). SAM-ovi se spontano formiraju izlaganjem metala otopini koja sadrži organske molekule sa samorganizirajućim svojstvima. Masne kiseline su karboksilne kiseline s dugim alifatskim lancima koje tvore SAM-ove i razgrađuju se većinom u produkte niske toksičnosti, što ih čini ekološki prihvatljivim. Korištenje takvih prevlaka bilo bi netoksično i potpuno sigurno za osobu koja nanosi prevlaku, kao i za osobu koja rukuje tretiranim predmetom. Međutim, SAM-ovi masnih kiselina se relativno lako razgrađuju, stoga je potrebno poboljšati njihovu stabilnost. Cilj predloženog projekta je dobivanje polimerne nano prevlake (PNP) na površini metala radijacijskim umrežavanjem SAM-ova masnih kiselina.U okviru predloženog projekta razvit će se vrlo jednostavna procedura za dobivanje PNP na bakrenoj površini koja se također može primijeniti za zaštitu drugih metalnih površina. Razvijene prevlake bile bi zamjena za tradicionalnu toksičnu i kratkoročnu zaštitu koja se danas koristi. Provedba predloženog projekta u skladu je s politikom usmjerenom prema zaštiti okoliša koja je u fokusu posljednjih desetljeća, gdje se ulažu veliki napori za prelazak s klasične kemije koja učestalo koristi toksične/kancerogene kemikalije i druge onečišćivače na nove i brze tehnologije koje ne štete okolišu.]]></summary_hr><summary_en><![CDATA[Radiation crosslinking refers to the process where high energy radiation, gamma-rays or fast electrons are used to induce a chemical reaction that results in formation of a 3D network. It is homogeneous, fast and avoids the use of toxic chemicals and is therefore considered environmentally friendly. Crosslinking hardens the coatings, reduces penetration of external molecules, improves mechanical strength and chemical resistance, as well as other functional properties making such coatings more resistant and significantly extending their lifetimes.A convenient way to obtain a compact, flawless coating with nano-order thickness is by forming thin self-assembled molecular layers (SAMs). SAMs form spontaneously by mere exposure of a metal to a solution containing organic molecules with self-assembling properties. Fatty acids (FA) are carboxylic acids with long aliphatic chains that form SAMs and biodegrade mainly into low toxic products, which makes them environmentally friendly. The use of such coatings would be non-toxic and completely safe for the person applying the coating, as well as the person handling the coated object. However, FA SAMs biodegrade relatively easy, it is thus necessary to improve their stability. The aim of the proposed project is to obtain a polymer nano coating (PNC) on the surface of metals by radiation crosslinking of FA SAMs.Within the proposed project a very simple procedure will be developed for obtaining PNCs on copper surface that can also be applied for the protection of other metal surfaces. The developed coatings would be a replacement for the traditional toxic and short-termed protection used today. The implementation of the proposed project is in accordance with the policy of environment friendly procurement that has been in focus for the last decades, where large effort is being made to switch from the classical chemistry using toxic/cancerous chemicals and other pollutants to new, swift and environment friendly technologies.]]></summary_en></project><project>
<id>9829</id><title_hr><![CDATA[Analiza zuba u forenzičnim i arheološkim istraživanjima]]></title_hr><title_en><![CDATA[Tooth Analysis in Forensic and Archaeological Research]]></title_en><user_id>3780</user_id><user_firstLast_name>Hrvoje Brkić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2020-02</proposal_call><code>IP-2020-02-9423</code><acronim><![CDATA[AZUFAMA]]></acronim><duration>01.02.2021 - 31.01.2025</duration><status>Završio</status><financ_value>87.146,13 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Dentalna medicina, Temeljne medicinske znanosti, Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Dental medicine, Basic Medical Sciences, Clinical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Stomatološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Dentistry]]></institution_en><team_members_id>29376, 2788, 2583, 29383, 4943, 27126, 29385, 855392, 855393, 855395, 865656, </team_members_id><team_members_names><![CDATA[Sandra Anić Milošević, Mario Šlaus, Marin Vodanović, Jelena Dumancic, Minja Birimiša , Ivan Galić, Jadranka Keros, Marina Marić, Ana Družijanić, Kurt W. Alt, Luka Banjšak, ]]></team_members_names><keywords_hr><![CDATA[forenzična stomatologija, zubi, dentalna dob, određivanje dentalne dobi, caklina, cement, bioarheologija]]></keywords_hr><keywords_en><![CDATA[forensic dentistry, teeth, dental age, dental age determination, enamel, cementum, bioarcaheology]]></keywords_en><summary_hr><![CDATA[Zubi i kosti čine izvor informacija o životu pojedinca. Zubi  dugo vremena ostaju sačuvani i nepromijenjeni nakon smrti, a može ih se analizirati skoro identičnim tehnikama koje se primjenjuju kod živih ljudi. Forenzična stomatologija dio je forenzične medicine, a bazira se na utvrđivanju identiteta nepoznatih ljudskih ostataka ili živučih ljudi u slučajevima kada za to postoji potreba. Svrha istraživanja je primjena različitih metoda za procjenu dentalne dobi u djece, adolescenata, odraslih osoba te na zubima iz arheoloških kolekcija kako bi se postigla najbolja metoda za određivanje dobi u svakodnevnoj forenzičkoj praksi. Također će se analizirati metrijske i nemetrijske varijable na zubima iz arheoloških kolekcija. U istraživanje će biti uključeni humani zubi na čijim će se presjecima korjenova mjeriti debljina cementa te korelirati sa poznatom dentalnom dobi. Određivanje dobi u djece i adolescenata provodit će se na rendgenskim snimkama iz kolekcije Zavoda za dentalnu antropologiju Stomatološkog fakulteta Sveučilišta u Zagrebu. Koristit ćemo nekoliko metoda za mjerenje razvoja korjenova trajnih zubi u donjoj čeljusti i statističkim postupcima korelacije s poznatom dobi nastojati dobiti najbolju mnetodu. Metrijske i nemetrijske varijable na zubima izvodit će se na zubima iz arheoloških kolekcija HAZU i centra za kulturu Vela Luka na uzorcima iz kasne antike, ranog srednjeg vijeka te IV. do I. stoljeća p.n.e. Na zubima biti će analizirani i stabilni izotopi C14, kisik i stroncij kako bi se utvrdilo točno vrijeme iz kojeg potjeću te način prehrane tijekom života. Očekujemo da će postignuti rezultati pomoći u stvaranju znanstveno dokazanih metoda primjenjivih na promatranim uzorcima te važan metodološki pristup u postupcima koji se izvode u forenzičnim i arheološkim analizama.  ]]></summary_hr><summary_en><![CDATA[Teeth and bones form the source of information about an individual&#39;s life. Teeth remain preserved and unchanged after death for a long time, and can be analyzed by almost identical techniques applied to living humans. Forensic dentistry is a part of forensic medicine, and is based on the identification of unknown human remains or living people when there is a need for that. The purpose of the study is to apply different methods to assess dental age in children, adolescents, adults, and teeth from archaeological collections, in order to obtain the best method for determining age in daily forensic practice. Metric and non-metric variables on teeth from archaeological collections will also be analyzed. The study will include human teeth on whose root sections the thickness of the cement will be measured and correlated with known dental ages. Determination of age in children and adolescents will be performed on x-ray images from the collection of the Department of Dental Anthropology, School of Dental Medicine, University of Zagreb. We will use several methods to measure the development of the roots of permanent teeth in the mandible, and try to correlate them with known age by using statistical analyzes in an effort to obtain the best method. Metric and non-metric variables on the teeth will be performed on the teeth from the archeological collections of Croatian Academy of Science and Arts and the Vela Luka Cultural Center on samples from late antiquity, Early Medieval times and 4th-1st century BC. Stable isotopes of C14, oxygen and strontium will also be analyzed on the teeth to determine the exact time from which they originate and to determine their diet. We expect that the results achieved will help to create scientifically proven methods applicable to the observed specimens, and an important methodological approach in the procedures performed in forensic and archeological analyzes]]></summary_en></project><project>
<id>9830</id><title_hr><![CDATA[Nabijena zemlja za modeliranje i normizaciju u potresno aktivnim područjima]]></title_hr><title_en><![CDATA[Rammed earth for modelling and standardization in seismically active areas]]></title_en><user_id>1408</user_id><user_firstLast_name>Ivan Kraus</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2020-02</proposal_call><code>UIP-2020-02-7363</code><acronim><![CDATA[RE-forMS]]></acronim><duration>31.12.2020 - 30.05.2026</duration><status>U tijeku</status><financ_value>263.985,67 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Građevinarstvo, Arhitektura i urbanizam, </scie_field_hr><scie_field_en>Civil engineering, Architecture and Urban Environment, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Građevinski i arhitektonski fakultet Osijek]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Civil Engineering and Architecture Osijek]]></institution_en><team_members_id>26657, 26620, 26642, 807, 20444, 11148, 864886, 3049, 862802, 869896, </team_members_id><team_members_names><![CDATA[Mihaela Domazetović, Jelena Kaluđer, Lucija Kraus, Paulina Krolo, Dario Iljkić, Ivana Varga, Ana Perić, Marin Grubišić, Ivana Brkanić Mihić, Petra Olić Miloš, ]]></team_members_names><keywords_hr><![CDATA[tradicijska arhitektura, kuća od nabijene zemlje, potresno inženjerstvo, toplinska svojstva, eksperimentalno ispitivanje, modeliranje, potresni stol]]></keywords_hr><keywords_en><![CDATA[traditional architecture, rammed earth house, earthquake engineering, thermal properties, experimental testing, modelling, shaking table]]></keywords_en><summary_hr><![CDATA[Zemljane kuće rješavaju pitanje stanovanja za 30 % svjetske populacije. Dostupni dokazi ističu Baranjske zemljane kuće kao najbolja ostvarenja hrvatskog seljačkog graditeljstva, a hrvatske tradicijske zemljane kuće svrstavaju u narodno bogatstvo jer utjelovljuju autentičnost. Iako prisutne, zemljane kuće u Hrvatskoj su napuštene, a kao domovi za moderno stanovanje se zaobilaze zbog povezivanja sa siromaštvom. Iako superiorna u pogledu ekološkog i održivog građenja, zemljin Kriptonit su mala krutost i niska čvrstoća. Hrvatska je smještena na trusnom području gdje je nužno projektirati potresno otporne kuće. No, aktualne norme za projektiranje ne prepoznaju nabijenu zemlju kao nosivi element, a time ne podržavaju građenje novih ili rekonstrukcije postojećih zemljanih kuća. Glavna hipoteza projekta utjelovljuje sinergiju suvremenog oblikovanja armiranobetonskih zidova i tradicionalnog građenja nabijenom zemljom. Terenskim istraživanjima će se prikupiti podatci i uzorci iz zemljanih kuća. Kontroliranim uzgojem i ispitivanjem svojstava više ratarskih kultura će se odrediti prirodna vlakna za strateško ojačavanje zidova od nabijene zemlje. Eksperimentalno će biti ispitana mehanička svojstva stabljika različitih ratarskih kultura za mikro-armaturu, a analogija armiranja betonskih zidova će biti primijenjena na nabijenu zemlju. U laboratorijima će se odrediti svojstva tradicijskih zemljanih uzoraka prikupljenih na terenu te poboljšanih i prirodnim vlaknima ojačanih zemljanih mješavina. Eksperimentalnim ispitivanjima zidova i modela kuća od nabijene zemlje će se istražiti njihovo toplinsko ponašanje te ponašanje na simulirano potresno djelovanje. Mjereni podatci će biti korišteni za studije primjenom nelinearnih računalnih simulacija. Projekt je transformacijski s očekivanim učinkom na očuvanje kulturne baštine, poticanje održivog građenja te izradu normi za projektiranje kuća od nabijene zemlje u potresno aktivnim područjima.]]></summary_hr><summary_en><![CDATA[Earth houses provide housing solution for 30 % of the world&#39;s population. Available evidence assert Baranja earth houses as masterpieces of Croatian rustic building and place vernacular Croatian earth houses as the national wealth as they embody authenticity. Albeit present, earth houses in Croatia are abandoned and bypassed for modern housing because of their association with poverty. Although superior in terms of ecological and sustainable building, earth&#39;s Kryptonite are its low stiffness and strength. Croatia is located in a seismic-prone area where it is binding to design earthquake resistant houses. Yet, current design standards do not recognize rammed earth as a load-bearing element, and thus do not support the construction of new or reconstruction of existing earth houses. The main hypothesis of the project embodies the synergy of modern design of reinforced concrete walls and traditional building with rammed earth. Data and samples from earth houses will be collected through field surveys. The controlled cultivation and testing of the properties of several agricultural crops will define the natural fibres for strategic reinforcement of rammed earth walls. The mechanical properties of the stems of different crops for micro-reinforcement will be experimentally tested, while the reinforcement of concrete walls analogy will be applied to the rammed earth. Properties of both traditional rammed earth samples from the field as well as improved rammed earth mixtures reinforced with natural fibres will be determined in laboratories. Via experimental testing of rammed earth walls and mock-up houses thermal performance and behaviour to simulated seismic action will be tested. Measured data will be used for studies by employing nonlinear computer simulations. The project is transformational with expected impact on the preservation of cultural heritage, encouraging sustainable building and developing norms for design of rammed earth houses in seismic-prone areas.]]></summary_en></project><project>
<id>9831</id><title_hr><![CDATA[Ekonomske katastrofe: frekvencija, determinante i efekti]]></title_hr><title_en><![CDATA[Economic Disasters: frequency, determinants and effects]]></title_en><user_id>19176</user_id><user_firstLast_name>Bruno Ćorić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2020-02</proposal_call><code>IP-2020-02-9710</code><acronim><![CDATA[ECONDIS2020]]></acronim><duration>08.03.2021 - 17.04.2025</duration><status>Završio</status><financ_value>57.833,43 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, </scie_field_hr><scie_field_en>Economy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Ekonomski fakultet]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Economics, Business and Tourism]]></institution_en><team_members_id>29193, 19207, 1210, 27231, </team_members_id><team_members_names><![CDATA[Merima Orlić, Vladimir Šimić, Lena Malešević Perović, Stjepan Srhoj, ]]></team_members_names><keywords_hr><![CDATA[ekonomske katastrofe, baza podataka, frekvencija, štednja, tokovi kapaitala, održivi razvoj]]></keywords_hr><keywords_en><![CDATA[economic disasters, data base, frequency, saving, capital flows, sustainable development]]></keywords_en><summary_hr><![CDATA[Pojam ekonomska katastrofa koristi se posljednjih godina u ekonomskoj literature za označavanje posebno velikih ekonomskih kriza, definiranih kao kumulativni pad bruto domaćeg proizvoda i/ili agregatne osobne potrošnje od 10 ili više posto. Nakon posljednje izrazito oštre financijske i ekonomske krize u 2008./2009. ekonomska znanost pokazuje sve veći interes za proučavanje financijskih i makroekonomskih efekata rijetkih ali ekstremno velikih kriza koje spadaju u kategoriju ekonomskih katastrofa. Ovaj istraživački projekt namjerava se fokusirati na četiri nove područja istraživanja vezana za ekonomske katastrofe.Prva predložena linija istrage će uključivati kreiranje nove globalne baze podataka o ekonomskim katastrofama. Naime, naša namjera ja značajno proširiti obujam postojeće baze podataka, kreirane od strane Barra i Ursúe (2008, 2012), koja pruža podatke za 42 zemlje i konstruirati globalnu bazu podataka o ekonomskim katastrofama. Globalna baza podataka će omogućiti analizu frekvencije i karakteristika ekonomskih katastrofa širom svijeta, kao i analizu njihove vremenske dinamike. Drugo područje istraživanja će se koncentrirati na istragu determinanti varijacija u frekvenciji ekonomskih katastrofa između zemalja, pri čemu će fokus biti stavljen na procjenu efekata ekonomske diversifikacije, kvalitete institucija i kvalitete ekonomske politike. Treći cilj predloženog projekta je procjena utjecaja ekonomskih katastrofa na stopu štednje i međunarodne tokove kapitala. Konačno, četvrta linija istrage će se koncentrirati na pitanje utjecaja ekonomskih katastrofa na održivi razvoj.]]></summary_hr><summary_en><![CDATA[The term economic disaster is used in the literature to distinguish especially large economic crises, defined as a cumulative decline in output and/or aggregate consumption over one or more years of at least 10 percent. Since the recent severe financial and economic crisis in 2008/2009, researchers have become increasingly interested in the financial and macroeconomic effects of the rare but extremely large economic crises, characterized as economic disaster. This research proposal focuses on four new lines of enquiry related to economic disasters. Our first line of enquiry will comprise the construction of a new global database on economic disasters. We plan to substantially extend the existing Barro and Ursúa (2008, 2012) database that provides data for 42 OECD and non-OECD countries and construct a global database on economic disasters. The global database will enable us to analyse the frequency and characteristics of economic disasters across the world and over time. The second line of enquiry will comprise an investigation of the determinants of variations in the frequency of economic disasters across countries with the focus on the effects of economic diversifications, quality of institutions, and the quality of economic policy. Our third goal is to investigate the effects of economic disasters on saving and international capital flows, while the final, fourth line of inquiry, will focus on the effects of economic disasters on sustainable development.]]></summary_en></project><project>
<id>9832</id><title_hr><![CDATA[Tekstilni materijali za povećanu udobnost u sportu]]></title_hr><title_en><![CDATA[Textile Materials for Enhanced Comfort in Sports]]></title_en><user_id>4945</user_id><user_firstLast_name>Ivana Salopek Čubrić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2020-02</proposal_call><code>IP-2020-02-5041</code><acronim><![CDATA[TEMPO]]></acronim><duration>01.01.2021 - 30.04.2025</duration><status>Završio</status><financ_value>91.446,01 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Tekstilna tehnologija, </scie_field_hr><scie_field_en>Textile technology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Tekstilno-tehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Textile Technology]]></institution_en><team_members_id>4951, 4820, 42, 26111, 1095, 19919, 29358, 864897, 865132, </team_members_id><team_members_names><![CDATA[Vesna Marija Potočić Matković, Goran Čubrić, Tomislav Rolich, Alenka Pavko Čuden, Daniel Domović, Željka Pavlović, Ines Katić Križmančić, Katarina Krstović, Antonija Petrov, ]]></team_members_names><keywords_hr><![CDATA[pletivo, funkcionalizacija, svojstva, udobnost, starenje, sportska odjeća, termografija, algoritam]]></keywords_hr><keywords_en><![CDATA[knitted fabric, functionalization, properties, comfort, aging, sportswear, thermography, algoritm]]></keywords_en><summary_hr><![CDATA[Kako zahtjevi krajnjih korisnika za proizvodnjom sportske odjeće s poboljšanim performansama rastu, misija znanstvenika da dizajniraju inovativne materijale postaje imperativom. Unutar projekta TEMPO okupljeni su znanstvenici različitih ekspertiza (dizajn materijala i vrednovanje svojstava, odjevno inženjerstvo, ljudski faktori i računalno modeliranje). Njihova je namjera međusobno se povezati i iskoristiti različite kompetencije kako bi proveli istraživanje koje je usmjereno na: (i) projektiranje inovativnih tekstilnih materijala (ii) optimalnih svojstava s (iii) dugotrajnom funkcionalnošću (iv) za personaliziranu odjeću, a sve podržano (v.) adekvatnim računalnim modelima. U svrhu mehaničke funkcionalizacije pletenih struktura, bit će projektirani i proizvedeni različiti uzorci. Temeljem vrednovanja strukturnih parametara, fizikalno-mehaničkih svojstava i svojstava koja određuju udobnost, provest će se optimizacija struktura te će biti razvijeni modeli algoritama strojnog učenja. Daljnji naglasak bit će na razvoju i validaciji protokola starenja materijala u različitim okruženjima, istraživanje svojstava materijala i definiranje algoritama za predviđanje funkcionalnosti proizvoda uslijed starenja. Termografija će se koristiti za mjerenje sportske odjeće u različitim okruženjima i poslužit će kao osnova za dizajn personalizirane sportske odjeće koja će poboljšati učinak sportaša. Predstavnici tekstilne industrije moći će koristiti rezultate istraživanja projekta TEMPO kako bi pronašli niše u proizvodnji prilagođene specifičnim potrebama pojedinaca. Rezultati istraživanja povećat će udobnost i funkcionalnost sportske odjeće, a razvijeni modeli moći će se primijeniti u izradi materijala i odjeće za različite ciljne skupine korisnika.]]></summary_hr><summary_en><![CDATA[As demands of end-users for sportswear with improved performance increase, the mission of scientists to design innovative materials for improved comfort becomes an imperative. Within the TEMPO project are gathered scientists with different core expertise, i.e. knitted fabric design and properties evaluation, clothing engineering, human factors and computational modelling. Their intention is to link with each and take advantage of different scientific backgrounds to start research that would be focused towards: (i.) design of innovative textile materials with (ii) optimal and (iii.) long-lasting properties (iv.) for personalized clothing and all supported by (v.) adequate computational modelling. For the purpose of mechanical functionalization of fabrics, various samples will be produced. Structural parameters, physical-mechanical and comfort properties will be measured and finally, structures will be optimized considering the obtained results and developed models of machine learning algorithms. Further emphasis will be on developing and validating protocols for materials aging in different environments, investigation of fabric properties and defining algorithms for the prediction of product functionality affected by aging. The thermography will be used for measurement of sportswear in different environment and it will serve as the basis for design of personalized sportswear that will enhance the performance of athlete.  In terms of TEMPO&#39;s outcomes, the representatives of textile industry will be able to use the research results to find niches in production geared to the specific needs of individuals. The research results will enhance the comfort and functionality of sportswear, and the developed models will have potential to be applied in fabrication of materials and clothing for different target groups of users.]]></summary_en></project><project>
<id>9834</id><title_hr><![CDATA[Model demijelinizacije na molekulskoj skali pri fiziološkim i patološkim uvjetima]]></title_hr><title_en><![CDATA[Model of demyelination on a molecular scale at physiological and pathological conditions]]></title_en><user_id>5002</user_id><user_firstLast_name>Danijela Bakarić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2020-02</proposal_call><code>UIP-2020-02-7669</code><acronim><![CDATA[DEMYMOLSCALE]]></acronim><duration>15.01.2021 - 14.01.2026</duration><status>U tijeku</status><financ_value>169.540,12 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, Fizika, Biologija, </scie_field_hr><scie_field_en>Chemistry, Physics, Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>6919, 864959, 855428, 24035, 869893, </team_members_id><team_members_names><![CDATA[Drazen Petrov Petrov, Petra Maleš, Lea Pašalić Pašalić, Barbara Pem, Vedrana Krajnović, ]]></team_members_names><keywords_hr><![CDATA[demijelinizacija, lipidne membrane, mijelin-bazični protein, fosfatidiletanolamin, inverzna heksagonska faza, FTIR spektroskopija, računalna kemija]]></keywords_hr><keywords_en><![CDATA[demyelination, lipid membranes, myelin basic protein, phosphatidylethanolamine, inverse hexagonal phase, FTIR spectroscopy, computational chemistry]]></keywords_en><summary_hr><![CDATA[Mijelin je višestruko-dvoslojna, pretežno lipidna ovojnica koja omata aksone i osigurava pravilan prijenos živčanih impulsa. Gubitak cjelovitosti mijelina u obliku njegovog prekomjernog odmotavanja, stvaranja vakuola te bubrenja dvosloja naziva se demijelinizacijom koja je povezana s multiplom sklerozom (MS). In vivo studije provedene na oboljelim životinjama pokazale su da su količine najzastupljenijih lipida, uključujući fosfatidiletanolamine (PE), značajno promijenjene u usporedbi sa zdravima, a prati ih i smanjena adhezivna aktivnost mijelin-bazičnog proteina (MBP). Utjecaj povećanja PE u mješovitim modelnim lipidnim membranama na temperaturu faznog prijelaza iz lamelarne (La) u inverznu heksagonsku (HII) fazu, koji pokazuje strukturne sličnosti s formiranjem vakuola, značajan je, ali prilično nedokučiv problem. Cilj ovog prijedloga je naći vezu između spomenute temperaturne promjene te veličine i rasporeda PE-domena u mješovitim modelnim lipidnim membranama uz i bez prisustva MBP-a. Modelne mijelinske membrane priredit će se iz najzastupljenijih mijelinskih lipida u skladu s njihovim omjerima u normalnim i oboljelim jedinkama. Uz različito okruženje PE domena unutar dvosloja, zajedno s promjenama u hidratacijskom mediju u pogledu prisustva MBP-a te ionskog sadržaja, sustavno će se proučiti promjene temperature La do HII faznog prijelaza PE domena. Detaljna molekularna slika tih događaja dobit će se kombinacijom temperaturno-ovisne IR spektroskopije i računalne kemije; strukturne promjene PE domena tijekom ove fazne promjene otkrit će se zajedno s interakcijama između PE, MBP i susjednih domena. Odredit će se parametri koji se smatraju najkritičnijima u smanjenju temperature faznog prijelaza La do HII. Osim razumijevanja demijelinizacije na molekularnoj razini, dobiveni rezultati će također pomoći u predlaganju mogućih rješenja u regulaciji lipidnog sastava lijekovima te odgovarajućom prehranom.]]></summary_hr><summary_en><![CDATA[Myelin is multibilayered, dominantly lipid sheath that enwraps axons and ensures proper transmission of neural impulses. Loss of myelin integrity in terms of redundant unwrapping, vacuole formation and swelling of the bilayer sheaths is referred as demyelination and is related to multiple sclerosis. In vivo studies reported that the amounts of representative lipids, including phosphatidylethanolamines (PEs), are significantly changed in diseased compared to healthy animals, and are further accompanied by reduced adhesive activity of myelin basic protein (MBP). The impact of the amount of PE in mixed model lipid membranes on the transition temperature between lamellar (La) to inverse hexagonal (HII) phase, where the latter shares structural features with vacuole formation, is significant but rather elusive issue. The aim of this proposal is to establish a link between this temperature change and the size and arrangement of PE domains in mixed model lipid membranes in the presence and absence of MBP. Model myelin membranes will be prepared from representative myelin lipids according to their ratios found in normal and diseased species. La to HII phase transitions of PE domains will be studied by probing different surroundings of PE domains within the bilayer, along with the variations in the hydrating medium regarding the presence of MBP and ionic content. A detailed molecular picture of these events will be provided by combining temperature-dependent IR spectroscopy and computational chemistry; structural changes of PE domain during this phase transition will be identified together with the interactions between PE, MBP and neighboring domains. As a result, the parameters considered as the most critical in reduction of La to HII phase transition temperature will be revealed. Aside of understanding demyelination at the molecular level, obtained results will help in suggesting possible solutions in lipid composition regulation by medications and appropriate nutrition.]]></summary_en></project><project>
<id>9835</id><title_hr><![CDATA[Svjetlošću pogonjena funkcionalizacija nereaktivnih pozicija korištenjem oksidacijske aminacije]]></title_hr><title_en><![CDATA[Light-Driven Functionalization of Unreactive Sites Using Oxidative Amination]]></title_en><user_id>4994</user_id><user_firstLast_name>Davor Šakić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2020-02</proposal_call><code>UIP-2020-02-4857</code><acronim><![CDATA[LIGHT-N-RING]]></acronim><duration>01.02.2021 - 31.01.2026</duration><status>U tijeku</status><financ_value>265.445,62 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Farmaceutsko-biokemijski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Pharmacy and Biochemistry]]></institution_en><team_members_id>29378, 864944, 6538, </team_members_id><team_members_names><![CDATA[Ana Karković Marković Karković Marković, Gabrijel Zubčić, Kristina Pavić, ]]></team_members_names><keywords_hr><![CDATA[aminacija, C-H aktivacija, stabilnost radikala, udaljena funkcionalizacija, priprema prstenova s heteroatomima]]></keywords_hr><keywords_en><![CDATA[amination, C–H activation, radical stability, remote functionalization, heteroatom-ring synthesis]]></keywords_en><summary_hr><![CDATA[C-H funkcionalizacijske metode koriste se za uvođenje novih funkcionalnih skupina i zbog toga se često koriste u farmaceutskoj industriji prilikom derivatizacije spoja uzora. Ove reakcije koriste nereaktivne sp3 C-H veze, čime je omogućeno učinkovitije istraživanje kemijskog prostora od konvencionalnih sinteza. Brojne istraživačke grupe aktivno pretražuju nove reakcije C-H funkcionalizacije u kojima je zadržana kemo-, regio- i stereo-specifičnost pri čemu se posebna pozornost pridaje lako pripremljenim prekursorima i blagim uvjetima reakcije. Potraga za reakcijama aminacije C-H veze u uvjetima bez metala nedavno je dovela do ponovne pojave interesa za Hofmann-Löffler-Freytag (HLF) reakciju i njene moderne varijante. HLF reakcijski niz uključuje stvaranje labilne N-halogene veze koja se zatim homolitički kida pri čemu nastaju nestabilni N-radikali, koji se dalje pregrađuju u stabilnije C-radikale. Stvaranjem C-halogen veze dovršava se postupak radikalnog lanca, a ciklizacija se odvija u sljedećem koraku prilikom obrade reakcije u lužnatim uvjetima. U ovom projektu istražit će se mehanizam reakcija aminacije C-H veza u odsustvu metalnih katalizatiora kako bi se otkrili potrebni kemijski prekidači i/ili reakcijski uvjeti za unaprijeđenje kemo-, regio- i stereo-specifičnosti, te bi se posljedično povećala upotrebljivost ovih reakcija. Cilj je kvantificirati učinke različitih elektron-odvlačećih skupina na (ne)stabilnost N-radikala, što izravno utječe na termodinamiku reakcije. Korištenjem podataka moći će se racionalno optimizirati sinteze s HLF reakcijama. Kompeticija između intra- i inter-molekularnih mehanizama analizirat će se kako bi se omogućilo bolje razumijevanje regioselektivnosti reakcije. Budući da neke od inačica reakcije u podlozi imaju ionski mehanizam, a ne radikalski mehanizam,  provest će se potraga za prekidačem koji određuje dominantnost mehanizma. Ovaj projekt olakšat će uspostavljanje nove istraživačke skupine na području fizikalne organske kemije.]]></summary_hr><summary_en><![CDATA[C-H functionalization methods are often used in the late-stage functionalization synthesis in the pharmaceutical industry to generate new compounds from a lead compound. These reactions utilize unreactive sp3 C-H bonds, providing a way for exploring chemical space more effectively than the conventional synthesis. Novel C(sp3)-H functionalization reactions with chemo-, regio-, and stereo-specificity, combined with easily prepared precursors under mild conditions are actively searched by numerous groups. The search for amination reactions of the C-H bond in metal-free conditions has recently led to a resurgence in the studies of the Hofmann-Löffler-Freytag (HLF) reaction and its modern variants. Current reaction sequence involves the generation of a labile N-halogen bond, followed by homolytic cleavage that produces unstable N-centered radicals, that undergo rearrangement reactions to the corresponding, more stable C-centered radicals. Formation of C-halogen bond completes the radical chain process, while subsequent cyclisation occurs in a non-radical step. In this project, the mechanism of metal-free C-H bond amination reactions will be explored to discover necessary chemical switches and/or reaction conditions to further increase the chemo-, regio-, stereo-specificity and the utility of these reactions. The goal is to quantify the effects of various electron-withdrawing groups on the N-centered radical (in)stability, which directly relates to the driving force of the reaction and uses this data for the rational design of HLF reactions. Competition between intra- and inter-molecular pathways must be analysed in more detail in order to offer a better understanding of the regioselectivity of the reaction. As some reaction variants proceed through ionic mechanisms, a search for a chemical mechanism switch will be conducted. This project will facilitate installation of the new research group in the physical organic chemistry field.  ]]></summary_en></project><project>
<id>9839</id><title_hr><![CDATA[Mikrobna ekologija jezerskih ekosutava - novi pristup ]]></title_hr><title_en><![CDATA[Microbial ecology of lake ecosystems – a novel approach]]></title_en><user_id>74</user_id><user_firstLast_name>Sandi  Orlić </user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2020-02</proposal_call><code>IP-2020-02-9021</code><acronim><![CDATA[MALENA]]></acronim><duration>01.02.2021 - 31.05.2025</duration><status>Završio</status><financ_value>132.590,09 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Interdisciplinarne prirodne znanosti, Geologija, Biologija, </scie_field_hr><scie_field_en>Interdisciplinary natural sciences, Geology, Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>25954, 25885, 27053, 865079, 869787, 865665, </team_members_id><team_members_names><![CDATA[Lorena Selak, Katarina Kajan, Deepak Kumaresan, Ivana Stanić, Iva Vojtkuf, Andrea Čačković Čačković, ]]></team_members_names><keywords_hr><![CDATA[bakterije, raznolikost, SSG, metanotrofi, klimatske promjene, jezera ]]></keywords_hr><keywords_en><![CDATA[bacteria, diversity, NGS, methanotrophs, climate changes, lakes ]]></keywords_en><summary_hr><![CDATA[Mikroorganizmi podržavaju kompleksne ekosustave održivim korištenjem sunčeve svjetlosti, vode, zraka i minerala kroz bezbrojne funkcije kao što su oksidacija i proizvodnja vodika, fiksacija CO2 i N2, metanogeneza i metanotrofija, fotosinteza i još mnogo toga. Nedavne globalne promjene sugeriraju da je Zemlja sada ušla u još jednu posebnu geološku eru, Antropocen, gdje neosporivo možemo identificirati dubok utjecaj ljudi na Zemlji, uključujući atmosferu, oceane i zemlju. Iako slatke vode čine samo oko 2,5% ukupnih vodenih masa Zemlje, jezera i drugi slatkovodni ekosustavi, osim što su glavni izvori pitke vode, neizmjerno su važni za globalni proračun ugljika i osjetljivi su pokazatelji globalnih i regionalnih promjena okoliša. Iako slatke vode čine oko 2,5% ukupne vode na Zemlji, jezera i druge unutarnje vode, osim što su glavni resursi pitke vode, nesrazmjerno su važni za globalni proračun ugljika i osjetljivi pokazatelj globalnih i regionalnih promjena u okolišu. Jezera emitiraju značajne količine stakleničkih plinova, posebno metana, stakleničkog plina koji je i dvadeset puta snažniji od ugljičnog dioksida. Procjenjuje se da ukupna emisija slatkovodnih stakleničkih plinova čini oko 22% ukupne globalne emisije metana i oko tri četvrtine svih prirodnih emisija. U Hrvatskoj su jezera vrlo ranjiva i izložena snažnom okolišnom i antropogenom utjecaju. Korištenjem najnovijih tehnologija u projektu MALENA želimo razumjeti značaj mikroba u kruženju metana u istraživanim jezerima. Rezultati ovog višefaznog projekta će dati značajne odgovore za funkcioniranje jezera kao i identifikaciju najznačajnijih igrača u kruženju metana. Konačno, cilj nam je formirati skupinu znanstvenika u mikrobnoj ekologiji globalnih promjena, jer očigledno da rješenja ekoloških problema i naše budućnosti zahtijevaju holistički pristup donošenju odluka, neosporno uključujući nova znanja o važnosti mikroorganizama.]]></summary_hr><summary_en><![CDATA[Microorganisms support complex ecosystems sustainably using sunlight, water, air and minerals through myriad functions as hydrogen oxidation and production, carbon dioxide and nitrogen fixation, methanogenesis and methanotrophy, photosynthesis and more. Recent global changes suggest that Earth has now entered another distinct geological era, the Anthropocene, where we can identify profound impact of humans on the Earth, including the atmosphere, oceans and land. Although freshwaters constitute only about 2,5% of the total Earth water, lakes and other inland waters, aside of being the principal drinking water resources are disproportionally important for the global carbon budget and sensitive indicators for global and regional environmental change. Lakes emit significant amounts of greenhouse gases, in particular methane, a greenhouse gas more that twenty times more potent than carbon dioxide. Total freshwater greenhouse gas emissions are estimated to make up around 22 % of total global methane emissions and around three quarters of all natural emissions. In Croatia, lakes are very vulnerable and subjected to strong environmental and anthropogenic influence. Using the state-of-the-art technologies in the MALENA project we want to understand the microbial significance in methane cycling in the investigated lakes. The results of this multiphasic project will give significant answers for the lake functioning as well the identification of the most significant players in the methane cycling. Finally, we aim to form a group of scientists in microbial ecology of global change, because evidently, solutions to environmental problems and our future require a holistic approach to decision taking, indisputably including knowledge of the role of microorganisms.]]></summary_en></project><project>
<id>9843</id><title_hr><![CDATA[Metaforičke kolokacije - sintagmatske sveze između semantike i pragmatike]]></title_hr><title_en><![CDATA[Metaphorical Collocations - Syntagmatic Word Combinations between Semantics and Pragmatics]]></title_en><user_id>25903</user_id><user_firstLast_name>Aneta Stojic</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2020-02</proposal_call><code>IP-2020-02-6319</code><acronim><![CDATA[MetaKol]]></acronim><duration>01.01.2021 - 31.12.2024</duration><status>Završio</status><financ_value>91.419,47 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filologija, Interdisciplinarne humanističke znanosti, </scie_field_hr><scie_field_en>Philology, Interdisciplinary humanities, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Filozofski fakultet u Rijeci]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>26148, 26490, 29391, 26480, 21089, 865, 26323, 4168, 5309, 866631, </team_members_id><team_members_names><![CDATA[Nataša Košuta, Ana  Keglević, Jakob Patekar, Christine Konecny, Marija Brkić Bakarić, Lucia Načinović Prskalo, Iva  Baric, Jana Jurčević, Mihaela Matešić, KATJA DOBRIĆ BASANEŽE, ]]></team_members_names><keywords_hr><![CDATA[kolokacijska sveza, leksikalizirana metafora, semantička kohezivnost, kolokacijski profil, idiosinkratičnost]]></keywords_hr><keywords_en><![CDATA[collocational word combinations, lexicalized metaphor, semantic-lexical cohesion, collocational profile, idiosyncrasy]]></keywords_en><summary_hr><![CDATA[Predloženo istraživanje bavi se analizom metaforičkih kolokacija. Dosadašnja istraživanja kolokacijske problematike još uvijek nisu uspjela odgovoriti na ključna pitanja o zakonitostima kolokacijskoga slaganja. Stoga je glavni cilj doći do novih spoznaja o procesu stvaranja kolokacijskih sveza te njihovim semantičkim i pragmatičkim obilježjima. Pretpostavka je da su procesi univerzalni te da se motiviranost značenja često temelji na metaforičnome značenju koje je specifično za pojedini jezik. Ono je s vremenom izblijedjelo čime je pospješena semantička kohezivnost među sastavnicama kolokacijske sveze što uvjetuje restriktivnost u kolokacijskome slaganju odnosno idiosinkratičnost. Istraživanje metaforičkih kolokacija sa semantičko-pragmatičkoga aspekta moglo bi stoga rasvijetliti prirodu kolokacijske sveze i pridonijeti njezinu jasnijem definiranju. Uz pomoć teorijsko-semantičkoga i računalnolingvističkoga pristupa teži se izradi paralelnih inventara metaforičkih kolocija u različitim jezicima te njihovoj analizi na semantičkoj i pragmatičkoj razini. Računalnolingvistički pristup uključuje istraživanje mogućnosti kombiniranja asocijacijskih mjera u kompleksnije modele s ciljem poboljšanja performansi postupka ekstrakcije metaforičkih kolokacija. Opravdanost predloženoga istraživanja metaforičkih kolokacija očituje se u omogućavanju veće vidljivosti i dostupnosti hrvatskoga jezičnog materijala u području (kognitivno)semantičkih istraživanja u europskome znanstvenome krugu i šire. Praktične implikacije rezultata istraživanja bit će primjenjive za ovladavanje jezikom, ali isto tako, u strojno čitljivome obliku, i za brojne zadatke računalne lingvistike i obrade prirodnoga jezika. Također, dobiveni rezultati u vidu sustavnoga lingvističkog opisa semantičkih i pragmatičkih aspekata kolokacijskih sveza primjenjivi su i u drugim lingvističkim disciplinama, ponajprije u primijenjenoj lingvistici, leksikografiji, translatologiji i glotodidaktici.]]></summary_hr><summary_en><![CDATA[The proposed research deals with the analysis of metaphorical collocations. Previous research on collocations has failed to answer key questions about the nature of collocations. Therefore, the main goal is to gain new insights into the process of creating collocations and their semantic and pragmatic features. The assumption is that the processes are universal and that the motivation of meaning is often based on metaphorical meaning that is specific to a particular language. It has faded through time, thus facilitating semantic cohesion among the components of the bound collocation, which leads to collocational restrictions and idiosyncrasy. The study of metaphorical collocation from the semantic-pragmatic aspect could therefore enlighten the nature of the collocations and contribute to its clearer definition. Based on the theoretical-semantic and computer linguistics approach we intend to build parallel inventories of metaphorical collocations in several languages as well as their analysis on semantic and pragmatic level. The computer linguistics approach involves exploring the possibilities of combining association measures in more complex models with the aim of improving the performance of the metaphorical collocation extraction process. The research enables greater visibility and availability of Croatian language material in the field of (cognitive) semantic research in the European scientific circle and beyond. The practical implications of research findings will be applicable to language learning, but also in the machine-readable form, and for numerous computer linguistics and natural language processing tasks. In addition, the findings obtained in the form of a systematic linguistic description of the semantic and pragmatic aspects of collocations are applicable to other linguistic disciplines, primarily in applied linguistics, lexicography, translation studies, and the study of language teaching.]]></summary_en></project><project>
<id>9845</id><title_hr><![CDATA[Razvoj sustava zasnovanih na učećim agentima za poboljšanje upravljanja prometom u gradovima]]></title_hr><title_en><![CDATA[Development of Learning Agent-based Systems for Improved Urban Traffic Control]]></title_en><user_id>2616</user_id><user_firstLast_name>Edouard Ivanjko</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2020-02</proposal_call><code>IP-2020-02-5042</code><acronim><![CDATA[DLASIUT]]></acronim><duration>15.01.2021 - 14.01.2025</duration><status>Završio</status><financ_value>144.513,90 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Tehnologija prometa i transport, Elektrotehnika, Računarstvo, </scie_field_hr><scie_field_en>Transport technology, Electrical engineering, Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet prometnih znanosti]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Transport and Traffic Sciences]]></institution_en><team_members_id>11309, 25505, 12323, 25560, 25509, 29067, 29087, 29068, 865173, 2741, </team_members_id><team_members_names><![CDATA[Daniela Koltovska Nechoska, Ivana Dusparic, Martin Gregurić, Dino Čakija, Krešimir Kušić, Mladen Miletić, Filip Vrbanić, René Schumann, Željko Majstorović, Tonči Carić, ]]></team_members_names><keywords_hr><![CDATA[inteligentni transportni sustavi,upravljanje prometom,višeagentni sustavi,strojno učenje,mikroskopske simulacije prometa,umrežena i autonomna vozila]]></keywords_hr><keywords_en><![CDATA[inteligent transport systems, traffic control, multi-agent systems, machine learning, microscopic traffic simulation, connected and autonmous vehicles]]></keywords_en><summary_hr><![CDATA[Današnja gradska okruženja sklona su dnevnim zagušenjima zbog visoke prijevozne potražnje. Razvoj sustava upravljanja prometom zasnovanih na strojnom učenju privukao je interes za stvaranje inteligentnih sustava s mogućnošću poboljšanja učinkovitosti prometne mreže. Primjena strojnog učenja u upravljanju prometom u gradskim sredinama sklona je problemu dimenzionalnosti. Na ponašanje sustava upravljanja utječe broj promatranih prometnih parametara koji opisuju okolinu u kojem upravljački sustav djeluje. Povećanje broja parametara uzrokuje eksponencijalno povećanje mogućeg prostora stanja i akcija čineći pronalazak optimalnog upravljačkog zakona u razumnom vremenu gotovo nemogućim. Skalabilnost istog prostora postaje vrlo važna. Također je potrebno steći povjerenje u rad sustava upravljanja zasnovanog na učećim agentima i u nepredviđenim situacijama. Upravljački zakon koji djeluje dobro u svim relevantnim prometnim stanjima važniji je od superiornih performansi u nekim stanjima. Stoga je podešavanje takvih sustava za značajne promjene u prijevoznoj potražnji vrlo problematičan ili čak neizvediv zadatak za operatere bez pomoći računala. Glavna snaga projekta DLASIUT je predloženi okvir za učenje i struktura sustava upravljanja prometom zasnovanog na učećim agentima sposobna naučiti optimalni upravljački zakon iz mikroskopskih simulacija s realističnim modelima gradske cestovne mreže. Dodatno, bit će dodana podrška za umrežena i autonomna vozila (CAV) koristeći ih kao dodatni upravljački izlaz koji osigurava primjenjivost sustava upravljanja u budućim miješanim prometnim tokovima s klasičnim i CAV vozilima. Dubinsko testiranje korištenjem realističnih simulacijskih modela i strukturiranih simulacija s gledišta tehnologije prometa radi identificiranja lošeg ponašanje sustava upravljanja, znatno će poboljšati trenutno znanje o takvim sustavima zasnovanim na strojnom učenju. Korist za stanovnike gradova je bolje upravljanje prometom te smanjenje zagušenja i emisija vozila.]]></summary_hr><summary_en><![CDATA[Today’s urban environments are prone to daily congestions due to dense traffic. The development of Machine Learning (ML) based traffic control systems for such environments gathered interest to create intelligent systems with the potential to improve the existing transport network efficiency. Applying ML in control of complex urban environments is prone to the curse of dimensionality. The controller behavior is influenced by the number of observed traffic parameters describing the environment in which it acts. Rising the number of parameters causes an exponential increase of possible state-action space, making it nearly impossible to find an optimal control policy in a reasonable time. The scalability of the same space becomes very important. It is also necessary to gain trust or confidence in the ML control system’s performance in unforeseen situations. Having a control policy that performs well in all relevant traffic states is more important than superior performance in some states. Thus, tuning of such systems for significant transport demand changes is very problematic or even infeasible for operators without computer support. The main benefit of the project DLASIUT is the proposed learning framework and structure of an agent-based traffic controller capable of learning the optimal control policy from microscopic simulations containing realistic models of a real-world urban road network. Additionally, support to Connected and Autonomous Vehicles (CAVs) will be added using them as an extra control output ensuring the applicability in future mixed traffic flows containing classic vehicles and CAVs. In-depth testing using realistic simulation models and Structured Simulation Framework from transport technology point of view to identify possible poor controller behavior will improve the state of the art of ML-based traffic controllers. The benefit for the citizens of urban environments is better traffic management and reduction of congestions and vehicle emissions.]]></summary_en></project><project>
<id>9849</id><title_hr><![CDATA[Pametni sustavi za dostavu lijeka pri liječenju tumora kosti]]></title_hr><title_en><![CDATA[Smart drug delivery systems in bone tumour treatment]]></title_en><user_id>12661</user_id><user_firstLast_name>Anamarija Rogina</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2020-02</proposal_call><code>UIP-2020-02-6201</code><acronim><![CDATA[SmartCar]]></acronim><duration>01.04.2021 - 31.03.2026</duration><status>U tijeku</status><financ_value>243.767,47 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Temeljne tehničke znanosti, Kemijsko inženjerstvo, Interdisciplinarne tehničke znanosti, </scie_field_hr><scie_field_en>Basic engineering sciences, Chemical engineering, Interdisciplinary technological sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet kemijskog inženjerstva i tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Chemical Engineering and Technology]]></institution_en><team_members_id>22929, 26757, 25959, 22646, 865015, 25290, 869481, </team_members_id><team_members_names><![CDATA[Antonia  Ressler, Dalibor Viderščak, Andrea Lončarević, Leonard Bauer, Luka Dornjak, Iva Bazina, Zoran Malbaša, ]]></team_members_names><keywords_hr><![CDATA[Dostavljači lijeka, hidrogel, terapeutski ioni, kompleksiranje, antitumorsko djelovanje]]></keywords_hr><keywords_en><![CDATA[Drug delivery systems, hydrogel, therapeutic ions, chelation, antitumor activity]]></keywords_en><summary_hr><![CDATA[Potreba za manje invazivnim liječenjem malignih bolesti potakla je nagli razvoj materijala kao potencijalnih dostavljača lijekova. Kemoterapija je konvencionalna metoda u liječenju tumorom zahvaćenog koštanog tkiva, osteosarkoma. Standardni postupci liječenja zasnivaju se na intravenoznoj ili oralnoj administraciji lijeka pri čemu se cijelo tijelo izlaže njegovom djelovanju prije dolaska na mjesto oboljenja. Pri tome lijek neizbježno djeluje na ostala tkiva povećavajući rizik od toksičnosti i neželjenih reakcija. Obećavajuća strategija poboljšanja terapije liječenja leži u primjeni manje količine lijeka na ciljano mjesto bez interakcija s okolnim tkivom. Ovaj projekt predlaže razvoj pametnih dostavljača antitumorskog lijeka (doksorubicina) na temelju kitozana modificiranog terapeutskim ionima: bakrom, cinkom, borom te fosfatima. Svestranost kitozana kao materijala sustavno smo istražili u našim prijašnjim istraživanjima pri čemu smo dokazali pozitivan učinak na razvoj matičnih stanica u novo koštano tkivo. Predloženo istraživanje je logičan slijed funkcionalizacije biokompatibilnog materijala kao nosača antitumorskog lijeka za ciljano liječenje osteosarkoma. Glavno istraživanje usmjerit će se prema: 1) razvoju pametnog dostavljača lijeka u obliku mikrosfera; 2) razvoju visokoporoznih okosnica kao nosača lijeka i terapeutika za obnovu tkiva; 3) modifikaciji materijala kalcijevim fosfatima za veću djelotvornost antitumorskog lijeka; 4) in vitro biološkoj validaciji materijala s ciljem utvrđivanja njihovog učinka. Očekuje se da će kombinacija antitumorskog lijeka i iona poput bakra, cinka i fosfata djelovati sinergijski na suzbijanje rasta tumorskih stanica te povećanje djelotvornosti lijeka bez utjecaja na zdravo tkivo. Također, očekuje se da će nosač modificiran borom osigurati dvostruko djelovanje: antitumorsko i terapeutsko, odnosno da će poticati vaskularizaciju i rast novog tkiva u koštanim defektima nastalim zbog bolesti. ]]></summary_hr><summary_en><![CDATA[The extensive development of materials as potential drug delivery systems has emerged from the need for less invasive treatment of malignant diseases. The chemotherapy is commonly used method for treating the osteosarcoma, type of a bone tumour that affects children and young adults. The standard procedures are based on intravenous or oral administration of antitumor drug that inevitably affects the whole body before reaching the infected tissue. Consequently, antitumor drug also interacts with healthy organs and tissues increasing the risk of toxicity and adverse drug effects. Arising new strategy for improved treatment is the encapsulation of drug within adequate carrier for controlled release under specific stimulus. This project brings forth the development of smart antitumor drug carriers based on chitosan modified with therapeutic ions: copper, zinc, boron and phosphate ions. In our previous studies, we have proved the versatility of chitosan-based materials as scaffolds that significantly support bone formation from stem cells culture. The proposed investigation is a logical continuation on the improvement of functionality of biocompatible materials in form of delivery carriers for targeted osteosarcoma treatment. The main research focuses on: 1) smart drug delivery systems as microspheres suitable for injection; 2) highly porous scaffolds as drug and therapeutic carriers for tissue regeneration; 3) materials modification by calcium phosphates to enhance the antitumor efficiency; 4) in vitro biological validation of prepared materials on healthy and tumour cells. We expect the synergic activity of antitumor drug (doxorubicin) and copper, zinc and phosphate ions in suppressing the grow th of osteosarcoma cells, as well as improvedefficacy without affecting the surrounding healthy tissue. Furthermore, we expect dual functionality, antitumor and therapeutic, of boron modified scaffolds in a way of inducing the vascularisation and neotissue growth. ]]></summary_en></project><project>
<id>9852</id><title_hr><![CDATA[Toll-like receptor 3 u razvoju i liječenju tumora glave i vrata: uloga endogenih liganada]]></title_hr><title_en><![CDATA[Toll-like receptor 3 in the development and treatment of human head and neck cancer: the role of endogenous ligands]]></title_en><user_id>12693</user_id><user_firstLast_name>Tanja Matijević Glavan</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2020-02</proposal_call><code>IP-2020-02-4225</code><acronim><![CDATA[TollTreatTum]]></acronim><duration>01.01.2021 - 31.12.2024</duration><status>Završio</status><financ_value>132.523,72 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>19432, 4968, 13128, 23871, 19882, 23356, 29483, 12651, 1189, 23594, 865131, 855421, 25005, </team_members_id><team_members_names><![CDATA[Martina Mikulandra, Danko Müller, Emilija  Zapletal, Marko Tarle, Pierre Busson, Koraljka Hat, Maja Sirotković Skerlev, Tina Catela Ivković, Ivica Lukšić, Sanda Bubanović, Iva Ledinsky Ledinsky, Tea Vasiljević, Kristina Vuković Đerfi, ]]></team_members_names><keywords_hr><![CDATA[tumori glave i vrata, Toll-like receptor 3, endogeni ligandi, matične stanice tumora, terapija tumora, ozračivanje, proteomika]]></keywords_hr><keywords_en><![CDATA[head and neck cancer, Toll-like receptor 3, endogenous ligands, cancer stem cells, tumor therapy, irradiation, proteomics]]></keywords_en><summary_hr><![CDATA[Toll-like receptori (TLR) su transmembranski proteini uključeni u pokretanje imunološkog odgovora. TLR mogu biti izraženi i na stanicama tumora gdje njihova uloga još nije do kraja razjašnjena. Aktivacija TLR3 pokreće se putem dsRNA podrijetlom od virusa ili sintetskim analogom (poly(I:C). TLR3 ima dvojnu ulogu u tumorima; njegovom aktivacijom pokreće se apoptoza, ali i i progresija tumora. U ovom ćemo projektu istraživati ulogu TLR3 u razvoju tumora s posebnim naglaskom na ulogu njegovih endogenih liganada. Ovi ligandi nastaju od nekrotičnih stanica tumora te mogu potaknuti progresiju raka. Istraživanja ćemo provoditi na nekoliko modela: a) reporterskoj liniji stanica za istraživanje TLR3 (HEK-Blue) gdje ćemo ispitivati hipotezu postojanja endogenih liganada za TLR3 dobivenih in vitro i in vivo iz nekrotičnog tkiva i stanica tumora, b) linijama stanica tumora glave i vrata stabilno transfeciranim sa shRNA za TLR3 i c) uzorcima tkiva izoliranih iz oboljelih od tumora glave. Drugi pristup uključivat će istraživanje uloge TLR3 i njegovih endogenih liganada u razvoju i samo-obnavljanju matičnih stanica tumora (CSC). Na kraju, pokušat ćemo razviti novu terapiju usmjerenu na CSC. Ove stanice pokazuju rezistenciju spram klasične terapije te mogu uzrokovati rekurenciju stoga je ciljanje ovih stanica razumna strategija u razvoju novih oblika terapija raka. Naš pristup uključivat će tretman s poly(I:C) i farmakološkim inhibitorima endogenih liganada u kombinaciji s ozračivanjem protonima ili gama-zrakama. Agonisti TLR3 već se istražuju kao potencijalni novi adjuvansi i pokretači apoptoze u liječenju tumora. Ovaj će se projekt fokusirati na donošenje novih spoznaja o dvojakoj ulozi TLR3 u tumorima i određivanju uvjeta pri kojima on djeluje pro-tumorski, a kada protu-tumorski. To je važno rasvijetliti prije uvođenja agonista TLR3 u kliničku praksu sa svrhom liječenja. ]]></summary_hr><summary_en><![CDATA[Toll-like receptors (TLRs) are transmembrane proteins involved in innate immune response. They can also be expressed on cancer cells where their role is still unresolved. TLR3 activation is triggered by dsRNA of viral origin or its synthetic analogue poly(I:C). TLR3 has a dual role in cancer; its activation triggers apoptosis as well as stimulates cancer progression. In this project we will explore the role of TLR3 activation in cancer development by focusing on the role of its endogenous ligands. These ligands originate from necrotic cancer cells and may stimulate cancer progression. We will study this on several models: a) TLR3 reporter cell line HEK-Blue to validate the in vivo and in vitro existence of TLR3 endogenous ligands derived from necrotic cells and tissue, b) head and neck cancer cell lines stably transfected with shRNA for TLR3 and c) cancer tissue specimens isolated from head and neck cancer patients. Second approach will include studying the role of TLR3 and its endogenous ligands in cancer stem cells (CSC) development and self-renewal. Lastly, we will seek to develop a novel anti-cancer therapy against CSC. These cells show resistance to classical therapy and may trigger recurrence thus targeting them is a reasonable strategy in cancer therapy development. Our approach will include combining proton or gamma-ray irradiation with the treatment with poly (I:C) and pharmacological inhibitors of endogenous ligands. TLR3 agonists are currently being investigated as potential novel cancer therapy adjuvants and apoptosis inducers. This project will focus on the delivery of new knowledge on the dual role of TLR3 in cancer and resolve the conditions in which TLR3 activation is either pro-tumorigenic or pro-apoptotic. It is of great importance to elucidate this before the introduction of TLR3 agonists into clinical practice.]]></summary_en></project><project>
<id>9853</id><title_hr><![CDATA[Određivanje uloga akvaporina 3 i 5 u razvoju rezistencije tumora dojke na oksidacijski stres]]></title_hr><title_en><![CDATA[Elucidating the role of aquaporins 3 and 5 in the development of breast cancer resistance to oxidative stress]]></title_en><user_id>5615</user_id><user_firstLast_name>Ana Čipak Gašparović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2020-02</proposal_call><code>IP-2020-02-3617</code><acronim><![CDATA[AquaBCaRe]]></acronim><duration>15.01.2021 - 14.01.2025</duration><status>Završio</status><financ_value>130.599,24 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>12664, 415, 23594, 25919, 865065, 866742, 25007, </team_members_id><team_members_names><![CDATA[Lidija Milković, Ivana Tartaro Bujak, Sanda Šitić, Graça Soveral, Monika Mlinarić, Ivan Lučić, Marko Tomljanović, ]]></team_members_names><keywords_hr><![CDATA[akvaporin 3, akvaporin 5, Nrf2, FOXO, tumor dojke]]></keywords_hr><keywords_en><![CDATA[aquaporin 3, aquaporin 5, Nrf2, FOXO, breast cancer]]></keywords_en><summary_hr><![CDATA[Otkriće akvaporina, membranskih pora koje kanaliziraju ulaz vode u stanicu, promijenilo je percepciju o pasivnom ulasku vode. Ovi transmembranski proteinski kanali građeni su kao tetrameri, a kod sisavaca je poznato 13 izomera. Izomeri se, ovisno o primanoj strukturi i specifičnoj permeabilnosti, dijele u tri skupine: na ortodoksne, koji primarno služe za transport vode, akvagliceroporine za transport glicerola i neortodoksne akvaporine, koji su isključivo na organelima. Uz vodu i glicerol, akvaporini provode i druge male nenabijene molekule kao što su: H2O2, urea, NO i CO2. Mogućnost provođenja navedenih molekula u stanicu objašnjava i funkcije akvaporina: održavanje ravnoteže vode u tkivima, migracija, proliferacija i adhezija stanica, čime neizbježno imaju ulogu u razvoju tumora. Kod tumora dojke, AQP3 se lokalizira uz NOX2 protein koji katalizira stvaranje H2O2 koji zatim AQP3 unosi u stanicu. U stanici, H2O2 modificira signalne puteve i potiče proliferaciju, dok je kod stanica s izraženim EGFR (locira se u lipidnim splavima membrane) neophodan za provođenje signala EGF-EGFR kaskadom. Istraživanja pokazuju povezanost akvaporina i signalnih puteva proliferacije, poput PI3K/Akt, u raznim humanim tumorima. Do sada nije istraženo kako H2O2 unesen akvaporinima regulira antioksidacijski sustav stanice. Pokazali smo da su AQP3 i AQP5 vezani uz NRF2 antioksidacijski transkripcijski faktor stoga ovaj projekt cilja razjasniti mehanizam kojim se ostvaruje ova korelacija. Regulacija unutarstaničnog oksidacijskog stresa akvaporinima bitan je u razvoju tumora s obzirom da izlaganje oksidacijskom stresu može potaknuti adaptaciju na stres, odnosno rezistenciju tumora na konvencionalne kemoterapeutike koji su bazirani na prekomjernom oksidacijskom stresu. Pojašnjavanje mehanizama djelovanja ova dva, za sada nepovezana sustava može poboljšati naše razumijevanje razvoja rezistencije tumora te otvoriti nove mogućnosti adjuvantne terapije tumora s boljim ishodom same terapije.]]></summary_hr><summary_en><![CDATA[Discovery of aquaporins, membrane pore which mediate water transport, changed our perception of passive water intake. In mammals, there are 13 isoforms of these tetrameric transmembrane channels. Isomers are grouped regarding their primary structure and specific permeability into three groups: orthodox, utilizing water transport, aquaglyceroporins, mediating glycerol transport and non-orthodox, localized specifically on organelle membranes. In addition to water and glycerol, aquaporins also channel other small, uncharged molecules such as H2O2, urea, NO and CO2. Transport of these molecules can contribute to understanding aquaporin functions: tissue water balance, migration, proliferation and adhesion. These functions inevitably link aquaporins to cancer. In breast cancer, AQP3 localizes by NOX2 which produces H2O2. This H2O2 is then channelled by AQP3 into the cell where it interacts with signalling pathways and stimulates proliferation. In EF receptor expressing cells (EGFR is located in lipid rafts) H2O2 is needed for the EGF-EGFR cascade. Studies show link between aquaporins and certain signalling pathways such as PI3K/Akt in different tumors. Interestingly, there is no dana on the link between aquaporin expression and antioxidative defence. We have previously shown that AQP3 and AQP5 are linked to NRF2 transcription factor, therefore in this project our aim is to clarify the mechanism of this relation. Regulation of intracellular oxidative stress by aquaporins is important in tumor development as oxidative stress cause adaptation to stress further leading to resistance to conventional tumor therapy. Revealing the mechanism oh these two systems can improve our knowledge of the tumor resistance and opens possibility of new adjuvant therapy with better outcome.]]></summary_en></project><project>
<id>9857</id><title_hr><![CDATA[Integrirana procjena odgovora akvatičkih organizama na izloženost metalima: ekspresija gena, bioraspoloživost, toksičnost i biomarkerski odgovori]]></title_hr><title_en><![CDATA[Integrated evaluation of aquatic organism responses to metal exposure: gene expression, bioavailability, toxicity and biomarker responses]]></title_en><user_id>12330</user_id><user_firstLast_name>Vlatka Filipović Marijić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2020-02</proposal_call><code>IP-2020-02-8502</code><acronim><![CDATA[BIOTOXMET]]></acronim><duration>28.12.2020 - 27.02.2025</duration><status>Završio</status><financ_value>162.253,63 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Interdisciplinarne prirodne znanosti, Kemija, Biologija, </scie_field_hr><scie_field_en>Interdisciplinary natural sciences, Chemistry, Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>6257, 2762, 11261, 21287, 24444, 26083, 26660, 26654, 26661, 865006, 865083, 866645, 869786, </team_members_id><team_members_names><![CDATA[Irena Vardić Smrzlić, Josip Barišić, Zrinka Dragun, Tatjana Mijošek, Zuzana Redžović, Tomislav Kralj, Thomas Prohaska, Donata Bandoniene, Andreas Zitek, Ivana Karamatić, Sara Šariri, Johanna Irrgeher, Marija Kuštro, ]]></team_members_names><keywords_hr><![CDATA[Metali, probavilo riba, kukaši, unos metala hranom, bioindikatori, kalcificirane strukture, testovi toksičnosti, otpadne vode]]></keywords_hr><keywords_en><![CDATA[Metals, fish intestine, acanthocephalans, dietary metal uptake, bioindicators, calcified structures, toxicity testing, wastewaters]]></keywords_en><summary_hr><![CDATA[Procjena izloženosti akvatičkih organizama metalima uključuje primjenu indikatorskih organizama i tkiva, najčešće jetre i škrga riba, školjkaša i rakova, međutim još uvijek postoji potreba za pouzdanim i osjetljivim bioindikatorima, koji bi odražavali biorasploživu, a time i potencijalno toksičnu razinu metala te ukazivali na kratkoročne i dugoročne promjene. Iako je probavilo rijetko korišteno kao bioindikatorski organ, aktualna je spoznaja da je unos metala hranom u ribe jednako važan kao i unos vodom. Rijetki podatci o razinama metala u probavilu riba uglavnom se uspoređuju s razinama metala u crijevnih nametnika kukaša, koji akumuliraju metale učinkovitije od drugih indikatorskih organizama. Do sada nije poznata bioraspoloživost metala unesenih hranom, kao ni mehanizam vezanja metala u kukaša te se planira po prvi puta odrediti udio metabolički raspoložive razine metala u probavilu riba te ekspresija gena u probavilu riba i kukašima u različitim uvjetima izloženosti metalima. Istraživanje će se provesti na rijeci Krki, koja je zbog čiste krške vode, ali i ulijevanja industrijskih i komunalnih otpadnih voda, prikladan ekosustav koji omogućava praćenje mehanizma toksičnosti metala, njihove akumulacije te bioloških odgovora u organizama pod različitim utjecajem onečišćenja. Utjecaj na organizme procijenit će se mjerenjem biokemijskih i histopatoloških markera, kao i koncentracija metala u probavilu i mišiću potočne pastrve, kukašima te kalcificiranim strukturama (otolitima i ljuskama) koje ukazuju na dugoročnu izloženost metalima tijekom rasta riba. Uz nativne, eksperimentalni organizmi (alge, Daphnia) ukazat će na potencijalnu toksičnost riječne i otpadne vode provođenjem testova toksičnosti. Sveobuhvatna procjena ekološkog stanja uključivat će određivanje razina metala u vodi i sedimentu rijeke Krke i četiri pritoke te po prvi puta omjera izotopa 87Sr/86Sr, kao markera geoloških značajki.]]></summary_hr><summary_en><![CDATA[Although there are common indicator organisms and tissues used in metal exposure assessment, mostly liver and gills of fish, bivalves and crustaceans, we are still in need of reliable and sensitive bioindicators, which will reflect bioavailable and therefore, possible toxic metal level, but also short and long term metal changes in the aquatic environment. Although fish intestine was rarely used as bioindicator tissue, the current studies indicate that both diet- and waterborne metal uptake are of equal importance for native fish. Rare data on intestinal metal levels were mostly related to metal levels in fish intestinal parasites, acanthocephalans, which accumulate metals more effectively than other indicator organisms. So far, there is no data on dietary metal bioavailability and on mechanism of metal binding in acanthocephalans, so it is planned for the first time to estimate metabolically available metal fraction in fish intestine and gene expression in fish intestine and acanthocephalans under different metal exposure regimes. Research will be performed in the Krka River, as suitable ecosystem for evaluation of metal toxicity, accumulation and biological responses in organisms under different pollution impact, due to clean karst water but also industrial and municipal wastewater discharges. Organism responses will be estimated by biochemical and histopathological markers, as well as metal levels in brown trout intestine and muscle, acanthocephalans and calcified structures (otoliths, scales), which indicate long term metal exposure during fish growth. Besides native, experimental organisms (algae, Daphnia) will indicate possible toxicity of the river and wastewater by toxicity testing. Comprehensive evaluation of ecological state will include determination of metals in the water and sediment of the Krka River and four tributaries and for the first time 87Sr/86Sr isotope ratio, as a natural marker of geological characteristics.]]></summary_en></project><project>
<id>9858</id><title_hr><![CDATA[Neretvanska mandarina-kemijska karakterizacija i inovativni tretmani poslije berbe]]></title_hr><title_en><![CDATA[Mandarins from Neretva Valley-Chemical characterization and Innovative postharvest TREAtments]]></title_en><user_id>26395</user_id><user_firstLast_name>Luna Maslov Bandić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2020-02</proposal_call><code>UIP-2020-02-7496</code><acronim><![CDATA[CITREA]]></acronim><duration>11.01.2021 - 10.01.2026</duration><status>U tijeku</status><financ_value>263.498,00 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, Prehrambena tehnologija, </scie_field_hr><scie_field_en>Agriculture, Food technology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Agronomski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Agriculture]]></institution_en><team_members_id>289, 12506, 27212, 20213, 21380, 20375, 869735, </team_members_id><team_members_names><![CDATA[Goran Fruk, Kristina Vlahoviček-Kahlina, Marija Sigurnjak Bureš, Slaven Jurić, Kristina Radić, Irina Tanuwidjaja, Dora Bošnjak, ]]></team_members_names><keywords_hr><![CDATA[neretvanska mandarina, kemijska karakterizacija, tretmani poslije berbe, jestivi omotači, toplinski tretmani, ukupni transkriptom]]></keywords_hr><keywords_en><![CDATA[mandarins from Neretva valley, chemical characterization, postharvest treatments, edible coatings, heat treatments, total transcriptome]]></keywords_en><summary_hr><![CDATA[Mandarina je sve popularnije voće jer se lako guli, ne sadrži sjemenke i ima specifičan okus omiljen potrošačima pa se globalna proizvodnja mandarina, kako u svijetu tako i u Hrvatskoj gdje se najviše uzgaja u dolini rijeke Neretve, konstantno povećava. Neretvanska mandarina postiže jedinstvenu kvalitetu ploda zbog mikroklimatskog utjecaja mora, rijeke Neretve te okolnih jezera. Nakon berbe, mandarine se mogu čuvati do 8 tjedana u hladnjači, ali neadekvatni uvjeti čuvanja mogu dodatno skratiti ovaj kratak period. Glavni gubici mandarina uzrokovani su gubitkom težine, bolestima, fiziološkim poremećajima i karantenskim štetočinama stoga se danas široko primjenjuju različite strategije čuvanja plodova nakon berbe. Ti tretmani uključuju prvenstveno primjene niskih temperatura, kemijske tretmane, toplinsku obradu, i nanošenje jestivih omotača koji pokazuju obećavajuće rezultate za očuvanje kvalitete plodova. Primjena ekološki prihvatljivih i inovativnih metoda koje ujedno i nisu skupe bio bi veliki korak naprijed u skladištenju mandarine. Ciljevi ovog projekta su napraviti potpunu i detaljnu kemijsku karakterizaciju sorata neretvanske mandarine kako bi se utvrdilo da li postoji kemotaksonomijski uzorak specifičan za mikroklimatske uvjete uzgoja mandarine u dolini rijeke Neretve; pripraviti, primijeniti i testirati ekološki inovativne jestive omotače s dodatkom ekstrakata komine grožđa, jabuke te kore mandarine, praćenjem metabolita kromatografskim metodama i ukupnog transkriptoma (RNA-Seq) najnovijim tehnologijama utvrdili bi se molekularni mehanizam u plodu mandarine tijekom primjene jestivih omotača i raznih tretmana čuvanja što će pridonijeti razumijevanju čimbenika i odabiru najpovoljnijih tretmana nakon berbe. Inovativni održivi jestivi omotači koji pokažu najbolje rezultate će kroz neposrednu diseminaciju stručnoj javnosti i proizvođačima biti od direktne koristi za unaprjeđenje proizvodnje mandarine u Hrvatskoj.]]></summary_hr><summary_en><![CDATA[Mandarin is an increasingly popular, easy-peeling and seedless fruit with a unique and favorite taste, so global mandarin production, both worldwide and in Croatia (where it is grown mostly in the Neretva valley), is constantly increasing. Mandarins from Neretva valley achieve unique fruit quality due to the microclimatic influence of the sea, the river and the surrounding lakes. After harvest, mandarines can be stored for up to 8 weeks in cool storage, but inadequate storage conditions can further shorten this short period. Major mandarine losses are caused by weight loss, disease, physiological disorders and quarantine pests thus different postharvest strategies are widely used today. These treatments primarily include storage at low temperatures, chemical treatments, heat treatments and application of edible coatings that show promising results for preserving fruit quality. Applying environmentally friendly and innovative methods that are not expensive at all would be a major step forward in mandarin storage. The objectives of this project are to make a complete and detailed chemical characterization of mandarin varieties from Neretva valley to determine whether there is a chemotaxonomic pattern specific to the microclimatic mandarin cultivation conditions in the Neretva valley; prepare, apply and test ecofriendly edible coatings with extracts of grape marc, apple marc and mandarine peel; metabolite characterization by chromatographic methods and total transcriptome sequencing using the latest deep-seq technologies  (RNA-Seq), assessment of molecular mechanism in mandarine fruit during the application of edible coatings and various treatments which will contribute to understanding the response and selecting the most suitable postharvest treatments. Innovative and “green” edible coatings that will exhibit the best performance will be, through direct dissemination to professional community and farmers, of direct benefit for improving mandarin production in Croatia]]></summary_en></project><project>
<id>9860</id><title_hr><![CDATA[Uloga proteina ADAR kod infekcije herpes simpleks virusom 1 ]]></title_hr><title_en><![CDATA[Roles od ADAR proteins in herpes simples virus 1 infection]]></title_en><user_id>43</user_id><user_firstLast_name>Igor Jurak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2020-02</proposal_call><code>IP-2020-02-2287</code><acronim><![CDATA[eRNA-HSV-IJ]]></acronim><duration>22.03.2021 - 21.06.2025</duration><status>Završio</status><financ_value>196.018,32 eur</financ_value><scie_area_hr>Interdisciplinarno područje znanosti</scie_area_hr><scie_area_en>Interdisciplinary scientific area</scie_area_en><scie_field_hr>Biotehnologija u biomedicini, </scie_field_hr><scie_field_en>Biotechnology in Biomedicine, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Fakultet biotehnologije i razvoja lijekova]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Biotechnology and Drug Development]]></institution_en><team_members_id>26487, 19177, 23303, 858, 23184, 865191, 865076, 867717, 868162, </team_members_id><team_members_names><![CDATA[Angela Gallo, Andreja Zubković, Ivan Šoša, Hackenberg Michael, Mia Cesarec, Antun Ferenčić, Adwait Anand Parchure, Umberto Rosani, Antonija Braut, ]]></team_members_names><keywords_hr><![CDATA[virus, HSV-1, herpesvirus,  mikroRNA, ADAR, editiranje, latencija]]></keywords_hr><keywords_en><![CDATA[virus, HSV-1, herpesviruses, miRNA, ADAR, editing, latency ]]></keywords_en><summary_hr><![CDATA[Herpes simpleks virus 1 je važan patogen ljudi koji se odlikuje replikacijom u dvije faze, produktivnom i latentnom. Otkriće velikog broja miRNA, malih regulatornih nekodirajućih RNA, diferencijalno eksprimiranih u produktivnoj i latentnoj fazi promijenio je dotadašnju paradigmu razumijevanja kontrole latencije. Nastavno na otkrića miRNA, naš laboratorij je nedugo otkrio iznenađujuće visoku razinu uređivanja (editing) jedne od miRNA, miR-H2, u latentno inficiranim stanicama neurona kod čovjeka. Pretpostavljamo da uređivanjem miR-H2 (emiR-H2) proširuje opseg ciljnih molekula, uključujući gene domaćina i virusa što bi moglo imati važnu ulogu u regulaciji latencije. Uređivanje RNA molekula vrše članovi obitelji proteina adenozin deaminaze (ADAR) koji imaju kritičnu ulogu u homeostazi. Kako bismo sveobuhvatno istražili ovaj fenomen i njegovu biološku relevantnost, sekvencirati ćemo RNA ljudskih stanice latentno inficiranih s HSV-1 ili HSV-2 te istražiti mete miRNA miR-H2 i emiR-H2. Pretpostavljamo da bi uređivanje miRNA moglo biti molekularna determinanta bioloških razlika između HSV-1 i -2 Nadalje, pokazano je da proteini ADAR mogu imati pro- i protuvirusnu ulogu kod infekcije, međutim uloga u infekciji HSV-1 je u potpunosti neistražena. U sklopu predloženog projekta ćemo istražiti ulogu ADAR proteina tijekom produktivne infekcije koristeći stanice s uklonjenim proteinima ADAR1 i ADAR2 te različitim virusnim mutantama. Pretpostavljamo da nedostak proteina ADAR bi mogao značajno djelovati na aktivaciju senzora dsRNA MDA5 i PKR i time na tijek infekcije. Osim toga, naši preliminarni rezultati ukazuju na masivnu translokaciju (pogrešnu lokalizaciju) ADAR1 nakon infekcije što ukazuje na specifičnu ulogu u infekciji te ćemo stoga odrediti i ADAR1 interaktom, odnosno proteinske partnere tijekom infekcije. Predloženo istraživanje će doprinijeti razumijevanju kompleksnih i kontradiktornih uloga ADAR proteina u latentnoj i produktivnoj infekciji. ]]></summary_hr><summary_en><![CDATA[Herpes simplex virus 1 is an important human pathogen that is characterized by two-stage replication, productive and latent. The discovery of a large number of miRNAs, small regulatory non-coding RNAs differentially expressed in the productive and latent phase has changed the paradigm of understanding latency control. Recently, our laboratory recently discovered a surprisingly high level of editing of one of the miRNAs, miR-H2, in latently infected human neuron cells. We hypothesize that editing miR-H2 (emiR-H2) expands the reach of target molecules, including host and virus genes, which could play an important role in regulating latency. The editing of RNA molecules is carried out by members of the adenosine deaminase (ADAR) protein family, which play a critical role in homeostasis. To comprehensively investigate this phenomenon and its biological relevance, we will sequence the RNAs of human cells latently infected with HSV-1 or HSV-2, and investigate the miRNA targets miR-H2 and emiR-H2. We hypothesize that miRNA editing could be a molecular determinant of biological differences between HSV-1 and -2 Furthermore, it has been shown that ADAR proteins may have a pro- and antiviral role in infection, however, the role in HSV-1 infection is completely unexplored. As part of the proposed project, we will investigate the role of ADAR proteins during productive infection using cells with ADAR1 and ADAR2 proteins depleted cells together with various viral mutants. We hypothesize that ADAR protein deficiency could significantly affect the activation of MDA5 and PKR dsRNA sensors and thus the course of infection. In addition, our preliminary results show massive translocation of ADAR1 after infection, indicating a specific role in infection, and thus we will determine the ADAR1 interactome, ie, protein partners during infection. The proposed research will contribute to understanding the complex and contradictory roles of ADAR proteins in latent and productive infection.]]></summary_en></project><project>
<id>9862</id><title_hr><![CDATA[Napredna gusta predikcija za računalni vid]]></title_hr><title_en><![CDATA[Advanced dense prediction for computer vision]]></title_en><user_id>361</user_id><user_firstLast_name>Siniša Šegvić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2020-02</proposal_call><code>IP-2020-02-5851</code><acronim><![CDATA[ADEPT]]></acronim><duration>01.02.2021 - 31.01.2025</duration><status>Završio</status><financ_value>181.830,25 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, Tehnologija prometa i transport, </scie_field_hr><scie_field_en>Computer sciences, Transport technology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>22805, 6351, 6914, 26974, 26969, 29639, 29637, 865352, 865533, 867622, 867621, 867620, </team_members_id><team_members_names><![CDATA[Petra Bevandić, Marko Ševrović, Axel Pinz, Ivan Grubišić, Marin Orsic, Marin Kačan Kačan, Josip Šarić, Matej Grcić, Iva Sović, Ivan Martinović, Anja Delić, Ivan Sabolić, ]]></team_members_names><keywords_hr><![CDATA[Računalni vid, strojno učenje, gusta predikcije, robusni modeli, polunadzirano učenje]]></keywords_hr><keywords_en><![CDATA[Computer vision, machine learning, dense prediction, robust models, semi-supervised learning]]></keywords_en><summary_hr><![CDATA[Ovaj prijedlog razmatra napredne metode guste predikcije za razumijevanje prirodnih slika u okviru kognitivnog računalnog vida. Fokus prijedloga je na semantičkoj segmentaciji gdje imamo najveće iskustvo, ali postignuti rezultati biti će primjenljivi i na druge zadatke poput rekonstrukcije dubine ili optičkog toka. Prijedlog razmatra važne probleme koji sprječavaju ili kompliciraju stvarne industrijske primjene. Predlažemo istraživanje tehnika za i) učinkovito učenje i zaključivanje, ii) otkrivanje izvandistribucijkih regija slike koje sustav ne može raspoznati, iii) postizanje robusnosti na neprijateljske napade, iv) učenje s nepotpunim nadziranjem te v) ostvarivanje primjenjivosti u prisustvu pomaka domene. Istraživanje će se temeljiti na dubokim konvolucijskim modelima za razumijevanje slike koje smo u posljednje četiri godine predstavili na najvažnijim konferencijama računalnog vida: ICCVW 2017, CVPRW 2018, CVPR 2019, CVPR 2020. Razvijene tehnike doprinijet će razvoju uzbudljivih primjena poput autonomnih vozila i robotskih robota, naprednih sustava za pomoć vozaču, analize satelitskih slika, inteligentnih sustava upravljanja voznim parkom ili sigurnsne inspekcije cestovnih prometnica.]]></summary_hr><summary_en><![CDATA[We consider advanced dense prediction techniques for natural image understanding in the frame of cognitive computer vision. We focus on semantic segmentation where we have most experience, but the results will also be relevant in other tasks such as depth reconstruction or optical flow. The proposal addresses important issues which hinder or complicate real-world industrial applications. In particular, we propose to study techniques for i) efficient learning and inference, ii) dense outlier detection, iii) defense against adversarial attacks, iv) training with incomplete supervision, and v) achieving applicability in presence of domain drift. The research will be based on deep convolutional models for image understanding which we have presented at top computer vision conferences in the last four years: ICCVW 2017, CVPRW 2018, CVPR 2019, CVPR 2020. The developed techniques shall contribute to development of exciting applications such as autonomous vehicles and warehouse robots, advanced driver assistance systems, analysis of satellite imagery, intelligent fleet management systems, or road safety inspection.]]></summary_en></project><project>
<id>9863</id><title_hr><![CDATA[Numerička rekonstrukcija u arheologiji pomorstva]]></title_hr><title_en><![CDATA[Numerical Reconstruction in the Archaeology of Seafaring]]></title_en><user_id>5521</user_id><user_firstLast_name>Irena Radić Rossi</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2020-02</proposal_call><code>IP-2020-02-3420</code><acronim><![CDATA[NEREAS]]></acronim><duration>01.02.2021 - 30.06.2025</duration><status>U tijeku</status><financ_value>117.459,69 eur</financ_value><scie_area_hr>Humanističke znanosti, Tehničke znanosti, </scie_area_hr><scie_area_en>Humanities, Technological sciences, </scie_area_en><scie_field_hr>Arheologija, Brodogradnja, Strojarstvo, </scie_field_hr><scie_field_en>Archeology, Naval architecture, Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zadru]]></institution_hr><institution_en><![CDATA[University of Zadar]]></institution_en><team_members_id>6254, 23217, 27122, 17691, 29542, 29554, 865260, 865184, 867434, </team_members_id><team_members_names><![CDATA[Smiljko Rudan, Albert  Zamarin, Davor Bolf, David Ruff, Sean Kery, Kotaro Yamafune, Šimun Sviličić, Nikola Budimir, Alice Lucchini, ]]></team_members_names><keywords_hr><![CDATA[arheologija pomorstva, numeričko modeliranje, numerička rekonstrukcija, amfora, brod, brodska konstrukcija, brodolom]]></keywords_hr><keywords_en><![CDATA[archaeology of seafaring, numerical modelling, numerical reconstruction, amphora, ship, ship structure, shipwreck]]></keywords_en><summary_hr><![CDATA[Projekt NEREAS interdisciplinarni je istraživački projekt u kojem se primjenom suvremenih inženjerskih alata dolazi do novih znanstvenih spoznaja u arheologiji pomorstva. Brodovi su konstrukcije čije se ponašanje uslijed djelovanja različitih opterećenja može predvidjeti računalnim simulacijama, putem metode konačnih elemenata. No, primjena takvih alata u arheologiji pomorstva vrlo je ograničena. Projektom NEREAS nastoji se kapitalizirati iskustvo međunarodnog tima u nastojanju da se fokusirano odgovori na niz istraživačkih pitanja te jasno demonstrira znanstvena opravdanost i značenje primjene suvremenih inženjerskih metoda u analizi pomorskih konstrukcija i događaja iz prošlosti. Nastavljajući dosadašnja istraživanja na temu amfora, projekt NEREAS razmatrat će utjecaj promjene njihovoga oblika na njihovu čvrstoću. Sustavno istraživanje različitih oblika amfora pružit će znanstvene dokaze o razlozima njihove evolucije. Uz to, analizirat će se utjecaj interpretacije, odnosno varijacija prilikom rekonstrukcije forme broda, uzrokovanih ograničenošću arheoloških nalaza, na stabilitet i pomorstvenost broda. Znanstvena utemeljenost rekonstrukcije iznimno je važna prilikom izrade replika. Projekt NEREAS unaprijedit će dosadašnje simulacije potonuća broda fokusiranjem na konkretan brodolom. Primjenom tih simulacija bit će moguće znanstvenim metodama, na osnovi materijalnih dokaza, odrediti najvjerojatniji scenarij koji je doveo do tragičnog događaja. Projekt NEREAS učinit će pionirske korake i u komparativnoj analizi konstrukcijskih detalja broda, izrađenih od drva kao gradivnog materijala koji je nekada bio živo biće. Konačno, zahvaljujući opremanju bazena za modelska ispitivanja provest će se eksperimentalna istraživanja u hidromehanici za brodove Gagliana grossa i Condura Croatica, oba od iznimnog značenja za povijest hrvatskog pomorstva. Projektom će se obuhvatiti i eksperimentalno modeliranje starenja brodske konstrukcije. ]]></summary_hr><summary_en><![CDATA[The NEREAS project is an interdisciplinary research project in which the use of modern engineering tools brings new scientific insights into the archeology of seafaring. Ships are structures whose behavior due to the action of different loads can be predicted by computer simulations, using the finite element method. However, the application of such tools in maritime archeology is very limited. The NEREAS project seeks to capitalize on the experience of the international team in the effort to focus on a range of research questions, and clearly demonstrate the scientific justification and significance of the application of modern engineering methods in the analysis of marine structures and events of the past.Continuing ongoing research on amphorae, the NEREAS project will consider the impact of changing their shape on their strength. A systematic exploration of the various forms of amphorae will provide scientific evidence of the reasons for their evolution. In addition, the influence of interpretation, that is, variations of the reconstruction of the shape of the ship, caused by the limited archaeological resources, on the stability and seaworthiness of the ship will be analyzed. The scientific foundation of reconstruction is extremely important when making replicas.The NEREAS project will enhance the shipwreck simulations, focusing on a specific shipwreck. It will be possible to determine, on the basis of material evidence, the most plausible scenario that led to the tragic event. The NEREAS project will also take pioneering steps in comparative analysis of the structural details of ship made of wood, as a building material that was once a living being. Finally, thanks to the equipping of the model testing pool, experimental research will be conducted in hydro-mechanics for the ships Gagliana grossa and Condura Croatica, both of great importance for the Croatian maritime history. The project will also cover the experimental modeling of aging of ship structure.]]></summary_en></project><project>
<id>9870</id><title_hr><![CDATA[Transferno područje od Sutle preko srednjeg toka Save tijekom brončanog i željeznog doba]]></title_hr><title_en><![CDATA[The Transfer Area from the Sutla River and across the Middle Course of the Sava River during the Bronze and Iron Ages]]></title_en><user_id>12736</user_id><user_firstLast_name>Janja Mavrović Mokos</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2020-02</proposal_call><code>UIP-2020-02-7127</code><acronim><![CDATA[TRANS RIVERS]]></acronim><duration>01.02.2021 - 31.01.2026</duration><status>U tijeku</status><financ_value>179.905,77 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Arheologija, </scie_field_hr><scie_field_en>Archeology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>29617, 13027, 29615, 864996, 867353, </team_members_id><team_members_names><![CDATA[Morena Želja Želle, Mateja Hulina, Mislav Fileš , Franka Ovčarić, Laura Šejić, ]]></team_members_names><keywords_hr><![CDATA[brončano i željezno doba, rijeke Sutla i Sava, transferni prostor, ubiciranje novih lokaliteta, kontrola prostora, analiza materijalne ostavštine]]></keywords_hr><keywords_en><![CDATA[Bronze Age, Iron Age, Sutla River, Sava River, transfer area, identification of new sites, control of space, analysis of material heritage]]></keywords_en><summary_hr><![CDATA[Projekt TRANS RIVERS bavit će se prostorom donjeg toka rijeke Sutle i srednjeg toka rijeke Save (od njene lijeve obale do zapadnih obronaka Medvednice) te prostorom istočnih obronaka Medvednice. Riječ je o ključnom području za kojega se pretpostavlja da je intenzivno sudjelovao u protoku i razmjeni ideja i dobara u prapovijesti, a posebno tijekom brončanog i željeznog doba. Bez obzira na to što je riječ o važnoj strateškoj poziciji koja je omogućavala kontrolu i prolaz kroz tzv. ˝brežička vrata˝, nakon kojega je rijekom Savom bio otvoren put trgovine i komunikacije sve do Podunavlja, za cijeli spomenuti prostor postoji vrlo malo podatka o životu u naseljima te načinu ukopavanja i asortimanu nalaza koji mogu govoriti o lokalnoj proizvodnji i/ili importu. Zbog toga su osnovni ciljevi ovoga projekta ubiciranje novih lokaliteta, interpretacija materijalne ostavštine s lokaliteta Sveti Križ i novootkrivenih lokaliteta te interpretacija uloge transfernog prostora od  Sutle do srednjeg toka rijeke Save u mreži komunikacije i razmjene dobara tijekom brončanog i željeznog doba. Lidarsko snimanje i intenzivni terenski pregledi omogućit će ostvarivanje prvog cilja, istraživanja na Svetom Križu i novootkrivenim lokalitetima reći će više o materijalnoj kulturi dok će se analizama zaokružiti sve dobivene podatke. Radiokarbonskim datiranjem će se zaokružiti tipo-kronološke postavke, residue analizama podatci iz naselja, dok će se metalografskim analizama dobiti podatci o sirovinama.]]></summary_hr><summary_en><![CDATA[The TRANS RIVERS project will cover the area of the lower course of the Sutla River and the middle course of the Sava River (from its left bank to the western slopes of Medvednica), as well as the eastern slopes of Medvednica. This is a key area assumed to have been heavily involved in the flow and exchange of ideas and goods in prehistory, and especially during the Bronze and Iron Ages. Regardless of the fact that this was an important strategic position that allowed for control and passage through the so-called &#39;&#39;Brežice gate&#39;&#39;, after which the trade and communication route was opened up to the Danube, we have very little information about the life in settlements, the burial rites and assortment of finds in the aforementioned area, that can speak about local production and/or import. Therefore, the main objectives of this project are the identification of new sites, the interpretation of the material heritage from the site of Sveti Križ and the newly-discovered sites, and the interpretation of the role of the transfer area from the Sutla River and across the middle course of the Sava River in the network of communication and exchange of goods during the Bronze and Iron Ages. Lidar scanning and intensive field surveys will enable us to fulfill the first objective, the excavations on Sveti Križ and the newly-discovered sites will provide insight into the material culture, and the analyses will enable us to complete the collected data. Radiocarbon dating will confirm the typo-chronological settings, the residue analyses will complete the settlement data, while the metallographic analyses will provide data on raw materials. ]]></summary_en></project><project>
<id>9880</id><title_hr><![CDATA[Livadni procjepak (Chouardia litardierei, Hyacinthaceae) kao istraživački sustav ekološke divergencije]]></title_hr><title_en><![CDATA[Amethyst meadow squill (Chouardia litardierei, Hyacinthaceae): a study system for ecological divergence]]></title_en><user_id>5829</user_id><user_firstLast_name>Ivan Radosavljević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2020-02</proposal_call><code>IP-2020-02-8099</code><acronim><![CDATA[AMS-EcolDiv]]></acronim><duration>01.01.2021 - 31.05.2025</duration><status>Završio</status><financ_value>191.784,46 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>29160, 29146, 18951, 13574, 29139, 29141, 29219, 865214, 25303, </team_members_id><team_members_names><![CDATA[Philippine Vergeer, Jernej Jakše, Krešimir Križanović, Boštjan Surina, Peter Glasnović, Živa Fišer, Snežana Dragićević, Sara Laura Šarančić, Damjan Mitić, ]]></team_members_names><keywords_hr><![CDATA[ekotip, ekološka divergencija, lokalna adaptacija, specijacija, reproduktivna izolacija, vrtni pokus, GWAS, GBS, epiGBS]]></keywords_hr><keywords_en><![CDATA[ecotype, ecological divergence, local adaptation, speciation, reproductive isolation, common garden experiment, GWAS, GBS, epiGBS]]></keywords_en><summary_hr><![CDATA[U populacijama koje je inicijalno nemoguće razlikovati bilo genetski ili fenotipski, nakupljanje genetskih razlika može dovesti do razvoja reproduktivne izolacije koja onemogućava daljnji protok gena između promatranih skupina. Kao posljedica prilagodbe organizama na specifične okolišne uvjete mogu se pojaviti novi ekotipovi, tj. skupine morfoloških i genetski diferenciranih jedinki. Istraživanje složenih interakcija između okoliša, fenotipa, epigenotipa i genotipa na grupi blisko srodnih jedinki koje su se prilagodile iznimno kontrastnim stanišnim uvjetima, stekli bismo dragocjena saznanja o mehanizmima koji su temelj jednog od osnovnih procesa evolucije: specijacije. S ciljem stjecanja što više spoznaja o ovoj problematici, livadni procjepak (Chouardia litardierei, Hyacinthaceae) izabran je kao istraživački sustav. Ovu specifičnu vrstu nalazimo u ekološki iznimno  kontrastnim okruženjima, od slanih obalnih staništa, preko vlažnih planinskih travnjaka, do visokoplaninskih, izuzetno suhih pukotina stijena na nadmorskim visinama iznad 2000 m. Planirano istraživanje provesti će se primjenom najmodernijih metoda pri čemu će se objasniti različiti aspekti procesa lokalne prilagodbe i ekološke divergencije. Koji geni se nalaze u osnovi prilagodbe organizama na lokalno specifične uvjete? Kako su strukturne razlike raspoređene unutar genoma različitih ekotipova i koja je njihova uloga u procesima lokalne prilagodbe i specijacije? Koje je značenje epigenetskih promjena u tom procesu? Koji mehanizmi se nalaze u osnovi razvoja i održavanja reproduktivnih barijera? Ovo su glavna pitanja na koja će se tražiti odgovori ovim znanstvenim projektom. Slijedeći najviše trenutne standarda unutar discipline, cjelokupno istraživanje bazirati će se na de-novo sastavljenom genomskom sklopu. Primjenom različitih, no iznimno kompatibilnih eksperimentalnih i analitičkih pristupa, dobiti će se iscrpan uvid u složeni proces lokalne adaptacije i ekološke divergencije odabrane biljne svojte.]]></summary_hr><summary_en><![CDATA[In populations that initially could not be distinguished from each other, either genetically or phenotypically, accumulation of genetic differences can gradually lead to development of reproduction isolation that disables any further gene flow between diverged groups. As a consequence of organism adaptation to specific environmental conditions, new ecotypes i.e. groups of morphologically and genetically divergent individuals, can emerge. By exploring complex interactions among environment, phenotype, epigenotype and genotype in a group of closely related organisms that have adopted to highly contrasting environments, we could gain a valuable knowledge of the mechanisms underlying one of the evolution’s fundamental process: the speciation. With intention of gathering as much information as possible on this subject, Amethyst Meadow Squill (Chouardia litardierei, Hyacinthaceae) was chosen as a study system. This exceptional monocot species inhabits highly contrasting environments, from saline habitats of seashores, across wet mountain grasslands, to subalpine, extremely dry rock crevices above 2000 m a.s.l. By using different state-of-the art approaches, different aspects of local adaptation and divergence process will be studied and explained. Which genes underlie organisms’ adaptation to contrasting environment? How are structural differences distributed across genomes of diverging organisms and what is their role in the local adaptation and speciation processes? What is the role of epigenetics in the process? Which mechanisms underlie development and maintenance of reproductive barriers? These are the major questions answers to which will be sought by this project. To follow the highest standards in the field, entire research will be based on draft genome assembly. By implementing different, yet highly compatible experimental and analytical approaches, thorough insight of the adaptive radiation process will be gained.  ]]></summary_en></project><project>
<id>9882</id><title_hr><![CDATA[Indirektni utjecaj globalnog zagrijavanja na fiziološke parametre sisavaca prehranom biljkama uzgojenim pri visokoj temperaturi]]></title_hr><title_en><![CDATA[Indirect Effect of Global Warming on Mammals Physiological Parameters via High Temperature-Stressed Plant Diet]]></title_en><user_id>6570</user_id><user_firstLast_name>Ivana Šola</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2020-02</proposal_call><code>IP-2020-02-7585</code><acronim><![CDATA[TEMPHYS]]></acronim><duration>15.02.2021 - 14.07.2025</duration><status>Završio</status><financ_value>178.777,08 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, Interdisciplinarne prirodne znanosti, </scie_field_hr><scie_field_en>Biology, Interdisciplinary natural sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>1076, 29317, 6029, 3390, 29393, 26566, 3156, 24193, 865215, 866628, 869844, </team_members_id><team_members_names><![CDATA[Svjetlana Terzić, Aurelio Gomez-Cadenas, Gordana Rusak, Valerija Vujčić, Miljenko Marušić, Vedran Balta, Ludwig-Müller Jutta, Ana Tot, Daria Gmižić, Alan Budisavljević, Marta Frlin, ]]></team_members_names><keywords_hr><![CDATA[globalno zatopljenje, ekosustav, metabolomika biljaka, fiziologija sisavaca, interakcija vrsta, dizajn modela]]></keywords_hr><keywords_en><![CDATA[global warming, ecosystem, plant metabolomics, animal physiology, species interaction, model design]]></keywords_en><summary_hr><![CDATA[Biljke izložene visokoj temperaturi (VT) adaptiraju se na molekularnoj razini kako bi održale normalne fiziološke funkcije. Varijacije u profilu metaboloma, transkriptoma i proteoma mogle bi imati značajan utjecaj na njihovu nutritivnu vrijednost, a indirektno prehranom i na zdravlje životinja. Malo je informacija o učincima biljaka uzgojenih pri VT na fiziologiju životinja koje ih konzumiraju, stoga je važno otkriti utječu li, kako i u kojoj mjeri promjene u biljnim metabolitnim profilima na fiziološke parametre sisavaca koji se njima hrane. Proučavanje fizioloških reakcija životinja na biljke izložene uvjetima VT kao hranu pomoći će razumijevanju prilagodbi ekosustava i projiciranju budućih ekoloških trendova. Naš je cilj istražiti indirektni (hranom posredovan) utjecaj VT okoliša na fiziologiju sisavaca, a kao modelni sustav koristit ćemo brokulu (Brassica oleracea botrytis var. cymosa) i miša (Mus musculus ) soj SWISS. Razvit ćemo HPLC i UPLC-MS/MS metode za analizu biljnih metabolita (flavonoida, hidroksicimetnih i hidroksibenzojevih kiselina, glukozinolata, vitamina B, C, D i E), uspostaviti protokol za in vitro i in vivo analizu indirektnog učinka VT na modelu miša, te u programskom jeziku R statističkim metodama izdvojiti parametre miša koji su najosjetljiviji na hranom posredovanu izloženost VT. Specifični doprinos će uključivati podatke o: a) termosenzitivnim i termostabilnim metabolitima u brokuli, b) metaboličkom i antioksidacijskom odgovoru klica i zrelih biljaka na VT, c) učinku VT na biološku sigurnost (cito- i genotoksičnost, utjecaj na staničnu proliferaciju i stupanj stvaranja ROS-ova) biljnog ekstrakta u stanicama sisavaca, te d) indirektnom (hranom posredovanom) učinku VT na (anti)oksidacijske, imunohematološke, metaboličke i lipidne parametre u serumu, jetri i bubrezima miševa. Rezultati će pridonijeti razumijevanju prehranom posredovanih posljedica globalnog zagrijavanja na životinje.   ]]></summary_hr><summary_en><![CDATA[Plants exposed to high temperature (HT) adapt at molecular level to maintain normal physiological functions. Variations in the metabolome, transcriptome and proteome profiles could have a significant impact on their nutritional value, and indirectly via diet on animal health as well. There are very little data on the effects of HT-grown plants on the physiology of mammals that feed on them, so it is important to find out whether, how and to what extent HT-induced changes in plant metabolites affect the physiology of mammals consuming them. Studying the physiological responses of animals to HT-grown plants as food will help us understand ecosystem adaptation process and project future ecological trends. Our goal is to investigate the indirect (diet-mediated) influence of HT on mammalian physiology, and we will use broccoli (Brassica oleracea botrytis var. cymosa) and mouse (Mus musculus) strain SWISS as a model system. We will develop HPLC and UPLC-MS/MS methods for analysis of plant metabolites (flavonoids, hydroxycinnamic and hydroxybenzoic acids, glucosinolates, vitamins B, C, D and E), establish a protocol for in vitro and in vivo analysis of the indirect effect of HT on mice, and in the programming language R by statistical methods identify mouse physiological parameters that are most sensitive to diet-mediated HT exposure. Specific contributions will include data on: a) thermosensitive and thermostable metabolites in broccoli, b) metabolic and antioxidant response of seedlings and mature plants to HT, c) effect of HT on biosafety (cyto- and genotoxicity, effect on cell proliferation and ROS production) of plant extract in mammalian cells, and d) indirect (diet-mediated) effect of HT on (anti)oxidative, immunohematological, metabolic and lipid parameters in serum, liver and kidneys of mice. The results will contribute to the predictions on diet-mediated indirect effects of global warming on animals.]]></summary_en></project><project>
<id>9886</id><title_hr><![CDATA[Longitudinalno istraživanje stresa adolescenata]]></title_hr><title_en><![CDATA[Longitudinal adolescent stress study]]></title_en><user_id>2729</user_id><user_firstLast_name>Goran Milas</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2020-02</proposal_call><code>IP-2020-02-6925</code><acronim><![CDATA[STRESS LOAD]]></acronim><duration>01.03.2021 - 28.02.2025</duration><status>Završio</status><financ_value>111.497,78 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Psihologija, </scie_field_hr><scie_field_en>Psychology, </scie_field_en><institution_hr><![CDATA[Institut društvenih znanosti Ivo Pilar]]></institution_hr><institution_en><![CDATA[Institute of Social Sciences Ivo Pilar in Zagreb]]></institution_en><team_members_id>2722, 5522, 24041, 22546, 29434, 29442, 29654, 29775, 865230, 866342, 5025, 867364, </team_members_id><team_members_names><![CDATA[Boris Mlačić, Renata Glavak Tkalić, Daniela  Šupe-Domić, Anja Wertag, Lada Stanišić, Josip Razum, Vanja Slijepčević Saftić, George Slavich, Filipa Ćavar, Maja Ribar Ribar, Stanko Rihtar, Petra Dumanić, ]]></team_members_names><keywords_hr><![CDATA[Životni stres, Adolescenti, Psihičke poteškoće, Longitudinalno istraživanje Salivarni kortizol, Upalni citokini]]></keywords_hr><keywords_en><![CDATA[Life stress, Adolescents, Psychological problems, Longitudinal study, Salivary cortisol, Inflammatory cytokines]]></keywords_en><summary_hr><![CDATA[Cilj je predloženog projekta pružiti preciznije informacije o odnosu stresa i psihičkih problema među adolescentima kao i biološke procese koji im stoje u osnovi (15-17), uzimajući u obzir brojne druge okolinske i dispozicijske faktore koji možda moderiraju njihovu vezu. U planiranom istraživanju namjeravamo objediniti tri metodološke kvalitete ključne za veću snagu nalaza i preciznost spoznaja koje su često nedostajale prethodnim istraživanjima: (a) potpuniju konceptualizaciju stresa (b) sagledavanje dinamike stresa i psihičkih problema u vremenskoj perspektivi (c) čvršće povezivanje psiholoških, objektivnih i bioloških pokazatelja stresa.Glavni dio studije zamišljen je kao longitudinalno panel istraživanje u četiri vala na reprezentativnom uzorku  od 2000 učenika srednjih škola koji će putem online platforme ispunjavati upitnike vezane uz stres, suočavanje, psihičke probleme, ličnost, obiteljske odnose i druge relevantne faktore. Neposredno po završetku longitudinalnog dijela istraživanja, izdvojit će se 200 -300 učenika koji će sudjelovati u drugom dijelu studije u kojem će se iz sline analizirati biološki biljezi stresa, salivarni kortizol i interleukini.Prikupljeni podaci rezultirat će podjednako teorijskom i praktičnom koristi, omogućit će testiranje  kauzalnih modela o mogućem utjecaju stresa na izraženost psihičkih problema adolescenata putem latentnog modela rasta (LGM), te unaprijediti metode ranog otkrivanja psihičkih poteškoća adolescenata vezanih uz stres i osnažiti mjere prevencije štetnih posljedica stresa prilagođene hrvatskim adolescentima.]]></summary_hr><summary_en><![CDATA[The present research aims to provide more specific information on the precise relationship between life stress exposure and psychological problems in adolescents (15-17 years old), as well as the biological processes underlying these effects. In addition, this research will consider several other factors that may moderate the relationship between life stress and psychological problems as part of a four-wave longitudinal study over two years.In the planned research, we intend to combine three methodological qualities crucial for strengthening these findings and obtaining more precise insights that were often lacking in previous research: (a) a more complete conceptualization of stress (b) monitoring the dynamical relationship between stress and psychological problems of adolescents in a time perspective (c) stronger linking of psychological, objective and biological indicators of stress within a single research.The main part of the study will be a unique four-wave longitudinal panel survey on a sample of high school students (ages 15 to 17).  who will fill out online questionnaires including measures of stress, coping, psychological problems, personality, family relationships and of other relevant constructs. Immediately upon completion of the longitudinal section of the survey, 200-300 students will be identified for further participation during which time biological samples—specifically, saliva—will be collected to obtain salivary cortisol and inflammatory cytokines (i.e., IL-6 and IL-1beta) concentration.The collected data will result in both theoretical and practical benefits. It will enable testing causal models of the possible impact of stress on the severity of adolescent psychological problems through a latent growth model (LGM), and help to improve methods for early detection of adolescent mental health problems related to stress, propose prevention measures, and recommend strategies for improving coping skills that are appropriate for Croatian adolescents.]]></summary_en></project><project>
<id>9895</id><title_hr><![CDATA[RANONOVOVJEKOVNE POMORSKE KARTE JADRANSKOG MORA: IZVOR SPOZNAJA, SREDSTVO NAVIGACIJE I MEDIJ KOMUNIKACIJE]]></title_hr><title_en><![CDATA[EARLY MODERN NAUTICAL CHARTS OF THE ADRIATIC SEA: INFORMATION SOURCES, NAVIGATION MEANS AND COMMUNICATION MEDIA]]></title_en><user_id>25896</user_id><user_firstLast_name>Josip Faričić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2020-02</proposal_call><code>IP-2020-02-5339</code><acronim><![CDATA[NACHAS]]></acronim><duration>15.12.2020 - 14.12.2024</duration><status>Završio</status><financ_value>57.403,54 eur</financ_value><scie_area_hr>Interdiciplinarne znanosti, Humanističke znanosti, Tehničke znanosti, Prirodne znanosti, Društvene znanosti, </scie_area_hr><scie_area_en>Interdisciplinary scientific area, Humanities, Technological sciences, Natural sciences, Social sciences, </scie_area_en><scie_field_hr>Geografija, Geofizika, Geodezija, Tehnologija prometa i transport, Povijest, Interdisciplinarne prirodne znanosti, </scie_field_hr><scie_field_en>Geography, Geophysics, Geodesy, Transport technology, History, Interdisciplinary natural sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zadru]]></institution_hr><institution_en><![CDATA[University of Zadar]]></institution_en><team_members_id>29421, 29418, 29325, 763, 29440, 29441, 29417, 29419, 865107, </team_members_id><team_members_names><![CDATA[Lena Mirosevic, Tome Marelić, Ivka Kljajić, Dubravka Mlinarić, Milorad Pavić, Josip Kasum, Dragan Umek, Orietta Selva, Julijan Sutlović, ]]></team_members_names><keywords_hr><![CDATA[kartografija, karta, pomorska karta, navigacija, Jadransko more]]></keywords_hr><keywords_en><![CDATA[cartography, map, nautical chart, navigation, Adriatic Sea]]></keywords_en><summary_hr><![CDATA[Stare karte moguće je istraživati s različitih motrišta, propitujući njihove najrazličitije komunikacijske kapacitete, posebno unutar  kartografskog diskursa višestrukog čitanja i tumačenja simbolične snage izvantekstualne komunikacije. Polazeći od dosadašnjih znanstvenih ostvarenja, ali i diskurzivnih postavki „nove kulturne kartografije“, ovim se projektom planira dopuniti postojeće spoznaje o ranonovovjekovnim pomorskim kartama Jadrana te na temelju interdisciplinarnoga pristupa, koji bi uvažio geografski, historiografski, geodetski i nautički diskurs, unaprijediti istraživanja pomorskih karata Jadrana, posebno u pogledu primjene kartometrijskih metoda i evaluacije kartografskih izvora kao medija komunikacije u prostoru i o prostoru. Radna je hipoteza da geografski sadržaj na pomorskim kartama ovisi o stupnju, odnosno količini i kvaliteti geografskih spoznaja o prikazanom prostoru, ali i o tome s kojega se motrišta neki prostor opaža i razmatra. Poseban aspekt istraživanja posvetit će se kartometrijskoj analizi uz korištenje različitih računalnih programa i alata, uključujući georeferenciranje starih pomorskih karata, vektorizaciju obalne crte i otoka te utvrđivanje kartografskih projekcija, mjerila karata, korelaciju orijentacijskog sustava s podatcima dobivenim iz modela za izračun povijesnih promjena magnetske varijacije, analizu preciznosti podataka o dubinama mora (koje su se sustavno na kartama počele prikazivati tek od druge polovine 18. st.) i dr. Na taj način trebao bi se dobiti jasniji uvid u upotrebljivost pomorskih karata kao sredstva na temelju kojega su se mogli dobiti pouzdani podatci iskoristivi u terestričkoj navigaciji u Jadranskom moru.]]></summary_hr><summary_en><![CDATA[Old maps can be studied from various standpoints and with various aims, examining their extremely varied communication capacities, particularly as part of recent cartographic discourse regarding multiple readings and interpreting the symbolic strength of extra-contextual communication. Starting from research achievements so far and the discourse tenets of a “new cultural cartography”, this project plans to supplement existing knowledge of early modern charts of the Adriatic and, pursuant to the interdisciplinary approach which acknowledges geographic, historiographic, geodetic and nautical discourses, advance research on nautical charts of the Adriatic, particularly in terms of applying cartometric methods and evaluating cartographic sources as media of communicating in space and about space. The working hypothesis is that the geographic content of nautical charts depended on the level, amount and quality of the geographical knowledge of the space depicted, but also on the standpoint from which that space was viewed and considered. A particular aspect of this research will be dedicated to a cartometric analysis using various computer programmes and tools, including georeferencing old nautical charts, the vectorisation of the coastlines of the mainland and islands, and establishing cartographic projections, map scales, the correlation of the orientation system with information taken from models for calculating historical changes in magnetic variation, analysis of precise data on sea depths (which only began to be shown systematically on charts in the latter half of the 18th century), and so on. In this way, a clearer picture should be gained of the usefulness of early modern charts as media for acquiring reliable data to use in terrestrial navigation in the Adriatic.]]></summary_en></project><project>
<id>9898</id><title_hr><![CDATA[Utjecaj inovativnih tehnologija na nutritivnu vrijednost, senzorska svojstva i oksidacijsku stabilnost djevičanskih maslinovih ulja iz hrvatskih autohtonih sorti maslina]]></title_hr><title_en><![CDATA[Influence of innovative technologies on nutritive value, sensory properties and oxidative stability of virgin olive oils from Croatian autochthonous olive varieties]]></title_en><user_id>13472</user_id><user_firstLast_name>Dubravka Škevin</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2020-02</proposal_call><code>IP-2020-02-7553</code><acronim><![CDATA[CROInEVVO]]></acronim><duration>01.01.2021 - 30.06.2025</duration><status>Završio</status><financ_value>145.493,17 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Prehrambena tehnologija, </scie_field_hr><scie_field_en>Food technology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Food Technology and Biotechnology]]></institution_en><team_members_id>12848, 13470, 13471, 2790, 13450, 26346, 25397, 855306, 865229, 3466, </team_members_id><team_members_names><![CDATA[Sandra Balbino, Marko Obranović, Klara Kraljic, Mirella Žanetić, Olivera Koprivnjak, Mia Ivanov, Valerija Majetić Germek, Urška Kosić, Katarina Filipan, Maja Jukić Špika, ]]></team_members_names><keywords_hr><![CDATA[djevičansko maslinovo ulje, nutritivna vrijednost, oksidacijska stabilnost, ultrazvuk, pulsirajuće električno polje, ubrzani toplinski tretman]]></keywords_hr><keywords_en><![CDATA[Virgin olive oil, nutritive value, oxidative stability, ultrasound, pulsed electrical field, rapid thermal treatment]]></keywords_en><summary_hr><![CDATA[Maslina je simbol mediteranske prehrane, glavni izvor masti i nutritivno vrijednih fitokemikalija. Ovisno o procesnim uvjetima proizvodnje djevičanskog maslinovog ulja (DMU), fitokemikalije prelaze iz ploda u ulje. Velik problem suvremene proizvodnje DMU je relativno slabo iskorištenje jer tijekom mljevenja ploda čak 20% stanica ostaje neoštećeno, a u razorenom materijalu dio ulja ostaje zarobljen u kompleksima sa koloidima čak i nakon miješenja. Ako tijekom mljevenja i miješenja nisu postignuti uvjeti za optimalnu aktivnost endogenih enzima ploda masline, veći dio polifenola ostat će u vegetabilnoj vodi, neće se formirati poželjna senzorska svojstva, a kvaliteta takvog DMU bit će slaba.Nedavna istraživanja izdvojila su primjenu ultrazvuka (UZV), pulsirajućeg električnog polja (PEP) te ubrzanog toplinskog tretmana (UTT) maslinovog tijesta prije miješanja, koja nudi mogućnost povećanja iskorištenja proizvodnje DMU s većim koncentracijama polifenola i poželjnih hlapljivih komponenti. Većina istraživača ističe presudnu važnost interakcije genetskih karakteristika sorte maslina i uvjeta primjene inovativnih tehnologija u proizvodnji DMOpći cilj ovog Projekta je stjecanje novih znanja o utjecaju UTT, UZV i PEP na nutritivnu vrijednost, senzorska svojstva, oksidacijsku stabilnost i iskorištenje proizvodnje DMU iz autohtonih hrvatskih sorti maslina. Budući da uvođenje inovacija u postojeće proizvodne sustave podrazumijeva dodatna financijska ulaganja, definirat će se ekonomski održiv postupak proizvodnje iz autohtonih sorti maslina primjenom inovativnih tehnologija. Statističkom obradom i matematičkim modeliranjem velikog broja prikupljenih podataka definirat će se precizni modeli procjene trajnosti DMU proizvedenih klasičnim i inovativnim tehnologijama. Kroz karakterizaciju i diferencijaciju monosortnih DMU iz odabranih sorti, ostvarit će se značajno proširenje baze podataka nutritivnih i senzorskih profila DMU iz hrvatskih autohtonih sorti.]]></summary_hr><summary_en><![CDATA[Depending on the processing conditions for the production of virgin olive oil (VOO), phytochemicals are extracted from fruit to oil. The problem of modern production of VOO is relatively poor yield. Reason is insufficient milling which leaves as much as 20% of cells intact and part of the oil remains trapped in colloidal complexes even after malaxation. If, during milling and malaxation, conditions are not met for optimal activity of endogenous enzymes from olive fruit, most of the polyphenols will remain in vegetable water, the desired sensory properties will not be formed, and the quality of such VOO will be poor. Recent research has singled out the use of ultrasound (US), pulsed electrical field (PEF) and rapid thermal treatment (RTT) of olive paste before malaxation, which offers the possibility to increase the yield of VOO production with higher concentrations of polyphenols and desirable volatile components. Most researchers emphasize the crucial importance of interaction between genetic characteristics of olive varieties and conditions of application of innovative technologies in VOO production. The general objective of this project is to acquire new knowledge about the influence of RTT, US and PEF on nutritive value, sensory characteristics, oxidative stability and yield of VOO production from autochthonous Croatian olive varieties. Since the introduction of innovations into existing production systems implies additional financial investments, an economically viable production process from Croatian olive varieties will be defined by applying innovative technologies. The statistical methods and mathematical modelling of a large number of collected data will define precise models for estimating the shelf life of VOO extracted by classical and innovative technologies. Through the characterization of monovarietal VOO from selected varieties, the database of nutritional and sensory profiles of VOO of Croatian autochthonous varieties will be significantly expanded]]></summary_en></project><project>
<id>9900</id><title_hr><![CDATA[ Novi modeli oštetljivosti tipičnih zgrada u urbanim područjima: primjene pri procjeni seizmičkog rizika i metodologiji ciljanih ojačanja]]></title_hr><title_en><![CDATA[ New vulnerability models of typical buildings in urban areas: applications to seismic risk assessment and target retrofitting methodology ]]></title_en><user_id>12842</user_id><user_firstLast_name>Mario Uroš</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2020-02</proposal_call><code>UIP-2020-02-1128</code><acronim><![CDATA[2BESAFE]]></acronim><duration>01.02.2021 - 31.01.2026</duration><status>U tijeku</status><financ_value>147.651,74 eur</financ_value><scie_area_hr>Tehničke znanosti, Prirodne znanosti, </scie_area_hr><scie_area_en>Technological sciences, Natural sciences, </scie_area_en><scie_field_hr>Građevinarstvo, Geofizika, Temeljne tehničke znanosti, </scie_field_hr><scie_field_en>Civil engineering, Geophysics, Basic engineering sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Građevinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Civil Engineering]]></institution_en><team_members_id>12891, 13076, 26417, 12913, 27185, 864977, 865121, 866676, </team_members_id><team_members_names><![CDATA[Marta Šavor Novak, Marija Demšić, Janko Košćak, Snježan Prevolnik, Senad Medić, Ante Pilipović, Romano Jevtić Rundek, Maja Baniček, ]]></team_members_names><keywords_hr><![CDATA[seizmički hazard, krivulje ranjivosti, krivulje oštetljivosti, složeni numerički proračuni, mehanizam otkazivanja, ciljano ojačanje, seizmički rizik]]></keywords_hr><keywords_en><![CDATA[seismic hazard, fragility curves, vulnerability curves, complex numerical analyses, collapse mechanism, target retrofit, seismic risk]]></keywords_en><summary_hr><![CDATA[Rizik od potresa je jedna od gorućih tema u Jugoistočnoj Europi, no djelovanje zajednice usmjereno na smanjenje posljedica potresa je vrlo ograničeno. Nedavni potresi u regiji su pokazali da posljedice potresa mogu biti katastrofalne. Kroz rad na procjenama rizika od katastrofa, identificirani su ključni problemi koji proizlaze iz neprikladnih ili nepostojećih modela oštetljivosti tipičnih zgrada u urbanim područjima. Predloženim istraživanjem će se donijeti nove i unaprijediti postojeće metode za cjelovito definiranje i opisivanje ponašanja konstrukcija pri djelovanju potresa. Fokus projekta će biti na tipovima zgrada za koje se procjenjuje da će biti najugroženije pri djelovanju potresa, značajno su nastanjene, a ujedno predstavljaju značajan dio fonda građevina urbanih područja u regiji. Provedbom projekta će se definirati seizmički hazard ovisno o seizmotektonskim uvjetima te će se formirati baza zapisa ubrzanja temeljnog tla. Primjenom suvremenih numeričkih metoda proračuna planira se sustavno opisati složene mehanizme otkazivanja odabranih konstrukcija, razviti nove modele vjerojatnosti oštećenja (ranjivosti) i oštetljivosti koji ne postoje u znanstvenoj literaturi te u konačnici razviti novu metodologiju za ciljano (optimalno) ojačanje najugroženijih tipova zgrada. Opisani sveobuhvatni pristup problemu otvara nove teme suradnje među znanstvenicima iz različitih područja stoga je za ostvarenje ciljeva formirana interdisciplinarna istraživačka skupina mladih znanstvenika. Svjesni važnosti i složenosti problematike, tim mladih znanstvenika je podržan i savjetovan od vodećih autoriteta u istraživačkom području iz Hrvatske, ali i iz međunarodnih centara znanja, uključujući mlade hrvatske znanstvenike u inozemstvu. Time bi se uspostavio centar izvrsnosti za napredne ocjene seizmičkog ponašanja i ojačanja zgrada što je neophodno za budući razvoj cjelovitog i pouzdanog modela seizmičkog rizika za regiju, te strategija za umanjenje posljedica.]]></summary_hr><summary_en><![CDATA[Seismic risk should be among key priorities in South-Eastern Europe, but activities of the community to its reduction are very limited. Recent earthquakes in the region have demonstrated that earthquake consequences may be disastrous. Crucial problems resulting from inadequate or non-existing vulnerability models of typical buildings in urban areas have been identified through research efforts on risk assessments. In the scope of the proposed project, new methods will be developed and existing ones enhanced, necessary for a complete definition and description of seismic structural performance. The project will focus on building types with expected high seismic vulnerability, which represent a significant part of the urban building stock in the region. In project implementation, seismic hazard, depending on the seismotectonic conditions, will be defined and database of ground acceleration records formed. It is planned to systematically describe complex collapse mechanisms of the selected structures, develop new fragility and vulnerability models which do not exist in scientific literature and finally, to develop a new methodology for target (optimal) retrofitting of the most vulnerable building types. The described comprehensive approach to the problem opens new topics for collaboration among scientists from different fields. Therefore, an interdisciplinary research group of young scientists is being established for the accomplishment of the project goals. Aware of the importance and complexity of the problem, the team of young researchers is supported and advised by leading authorities in the research field from Croatia, but also from international knowledge centres, including young Croatian scientists abroad. This would establish a centre of excellence for advanced assessments of seismic performance and retrofit of buildings, necessary for the future development of a complete and reliable seismic risk model for the region, as well as strategies for risk mitigation.]]></summary_en></project><project>
<id>9902</id><title_hr><![CDATA[Biološka, kronološka i relativna dob u funkciji uspostave nacionalnog sustava detekcije i razvoja sportskih talenata ]]></title_hr><title_en><![CDATA[Biological, chronological and relative age in establishing the croatian sports talent system ]]></title_en><user_id>784</user_id><user_firstLast_name>Dražen Čular</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2020-02</proposal_call><code>IP-2020-02-3366</code><acronim><![CDATA[BKRD]]></acronim><duration>18.01.2021 - 17.05.2025</duration><status>Završio</status><financ_value>112.616,63 eur</financ_value><scie_area_hr>Društvene znanosti, Biomedicina i zdravstvo, Biotehničke znanosti, </scie_area_hr><scie_area_en>Social sciences, Biomedicine and health sciences, Biotechnical sciences, </scie_area_en><scie_field_hr>Kineziologija, Temeljne medicinske znanosti, Javno zdravstvo i zdravstvena zaštita, Biotehnologija u biomedicini, </scie_field_hr><scie_field_en>Kinesiology, Basic Medical Sciences, Public health and health services, Biotechnology in Biomedicine, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Kineziološki fakultet]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Kinesiology]]></institution_en><team_members_id>4737, 2540, 1253, 182, 1482, 26605, 4560, 3935, 26409, 4267, 25480, 865174, 3813, 18978, </team_members_id><team_members_names><![CDATA[Damir Zubac, Zoran Grgantov, Ana Kezić, Tina Tičinović Kurir, Igor Jelaska, Sunčica Delaš Kalinski, Vladimir Ivančev, Zoran Valić, Nina Briški, Marija Pezer, Ana Majić, Matej Babić, Tea Bešlija, Johnny Padulo, ]]></team_members_names><keywords_hr><![CDATA[sport, biološka dob, relativna dob, koštana dob, detekcija, selekcija, talenti, sazrijevanje, starenje, DNA, glycani, vrhunac ubrzanog rasta sport, ]]></keywords_hr><keywords_en><![CDATA[bone age, detection, selection, talents, maturation, ageing, DNA, glycans, peak height velocity]]></keywords_en><summary_hr><![CDATA[Identifikacija talenata u sportu pretpostavlja prepoznavanje darovitih s ciljem maksimalnog ostvarenja njihovih potencijala, pri čemu se često zanemaruje biološka i relativna dob. Ciljevi projekta su: 1) Ojačati hrvatski potencijal razvoja sportskih talenata povezivanjem: nacionalnih saveza, trenera i znanstvenih institucija, 2) Istražiti povezanost biološke i relativne dobi sa postignutim rezultatima, 3) Generirati nova znanja u području biološke dobi i kontraktilnih svojstava skeletnih mišića, 4) Ojačati svijest o važnosti biološke dobi u procesu razvoja sportskih talenata. Na uzorku (n=>480) sportaša registriranih pri nacionalnim savezima (n=5), prikupit će se podaci o: spolu, kronološkoj/biološkoj/relativnoj dobi, postignutim rezultatima, zdravstvenom i reprezentativnom statusu. Relativna dob će se temeljiti na datumima rođenja. Procjena biološke dobi provest će se: a) metodom procjene somatske zrelosti, b) analizom glikozilacije IgG-a koja se mijenja s dobi i c) metodom procjene koštane zrelosti snimanjem šake ispitanika. Kontraktibilna svojstva skeletnih mišića analizirat će se primjenom neinvazivne TMG metode. Istražit će se upotrebna vrijednost primijenjenih metoda na uzorku ispitanika podijeljenih na tri subuzorka: a) usporen , b) normalan i c) ubrzan razvoj. Primjenom HI kvadrat testa ispitat će se značajnost razlika u proporcijama zastupljenosti uspješnih, odnosno neuspješnih sportaša. Doprinos prediktora uspješnosti u pojedinom sportu ispitivat će se primjenom naprednih regresijskih modela. Realizacija projektnih aktivnosti rezultirat će: a) provjerom postojanja RAE efekta, b) provjerom upotrebne vrijednosti primijenjenih metoda procjene biološke dobi i kontraktilnih svojstava skeletnih mišića. Za očekivati je da primjena rezultata u praksi doprinese smanjenju pogrešaka u selekciji, smanjenju odustajanja od sporta i uspostavi nacionalnog sport talent sustava.]]></summary_hr><summary_en><![CDATA[Sports talent identification implies identification of the gifted, so as to achieve their fullest potential, often neglecting biological and relative age. Project objectives are: 1) To strengthen Croatian potential of sports talent development by connecting: national federations, local community, coaches and scientific institutions; 2) To investigate the correlation of biological and relative age with results; 3) To generate new knowledge on the usefulness of the instrument for assessing biological age and muscle contractile; 4) To strengthen awareness on the importance of biological age in the process of sports talent development. On a sample of athletes (n=>480), registered by national federations (n=5), data on gender, achieved results, training, representative and health status will be collected. Relative age will be based on date of birth. Biological age will be assessed by: a) somatic maturity assessment method, b) analysis of IgG glycosylation, which changes with age, and c) by method of assessing skeletal maturity of subjects’ left hand. Muscle contractile properties will be analysed by TMG method. The usefulness of the applied methods will be analysed on a sample of Croatian athletes divided into three subsamples: a) delayed, b) average and  c) advanced growth. the Chi-Square Test will be used to test the significance of differences in the proportions of successful and less successful athletes. Contribution of different predictors of success will be assessed by employing advanced statistical regression models. Project activities should result in: a) testing the existence of the RAE effect, b) testing the usefulness of the applied instruments on a sample of young Croatian athletes. It is to be expected that the application of the Project results in practice will contribute to: reduction of wrong selection, reduction of the level of sport drop-outs, establishment of the Croatian national sports talent system.]]></summary_en></project><project>
<id>9905</id><title_hr><![CDATA[Ruske književne transformacije od 1990. do 2020. ]]></title_hr><title_en><![CDATA[Russian Literary Transformations from 1990 to 2020 ]]></title_en><user_id>5143</user_id><user_firstLast_name>Jasmina Vojvodić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2020-02</proposal_call><code>IP-2020-02-2441</code><acronim><![CDATA[Transform ]]></acronim><duration>15.01.2021 - 14.01.2025</duration><status>Završio</status><financ_value>83.150,84 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filologija, </scie_field_hr><scie_field_en>Philology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>6551, 6512, 3595, 6853, 18976, 29019, 29119, 29021, 865119, </team_members_id><team_members_names><![CDATA[Živa  Benčić-Primc, Ivana  Perusko, Danijela Lugarić Vukas, Josip  Užarević, Zoran Tihomirović, Nataliya Zlydneva, Olga Burenina-Petrova, Brigitte Obermayr, Petra Grebenac, ]]></team_members_names><keywords_hr><![CDATA[suvremena ruska književnost, transformacije, poetički sustav od 1990. do 2020., prijelazno književno razdoblje, književni pravci i poetičke škole]]></keywords_hr><keywords_en><![CDATA[contemporary Russian literature, transformations, poetic system from the 1990s to 2020, transitory literary period, literary movements and schools]]></keywords_en><summary_hr><![CDATA[Svi pregledi i teorijski uvidi suvremene ruske književnosti govore da je trenutno područje istraživanja recentne ruske književnosti disperzirano, bez jasnih poetičkih odrednica. U suvremenoj humanistici, napose rusistici i šire slavistici, nedostatna su sintetska istraživanja. Projektni prijedlog ruskih književnih transformacija od 1990. do 2020. nastoji znanstveno i analitički prevladati disparatnost i nepreglednost u dosadašnjim istraživanjima, registrirati, usustaviti i opisati postojeće pravce i tendencije u rečenom razdoblju te ih analitički obrazložiti. Projektni prijedlog ruskih književnih transformacija od 1990. do 2020. ima jasan teorijski okvir koji se temelji na postavljenoj hipotezi o važnosti početne točke (1990. godina) koja označava kulturno-povijesnu i društveno-političku prekretnicu i završne (2020. godina) kao završetak desetljeća i našu najbližu suvremenost, što odgovara književnim tendencijama trenutka, „sada i ovdje“. Pretpostavljamo da na temelju dosadašnjih saznanja i budućih istraživanja možemo jasno pokazati promjene u poetičkom sustavu koje se događaju od 1990-ih  prema 2000-im godinama te novi poetički zaokret u vremenu od 2010. godine naovamo. Projektni prijedlog ima lokalnu i globalnu relevantnost. Lokalnu jer nas zanimaju kretnja ruske književnosti u kontekstu specifičnih ruskih književnih i kulturnih tradicija, a globalnu jer ćemo svoja istraživanja povezati s globalnim tendencijama razvoja književnog polja te time ponuditi daljnje smjernice u proučavanju suvremene ruske književnosti kao svjetskog fenomena. Takva cjelovita istraživanja ruske književnosti još nema ni u hrvatskoj, ruskoj niti europskoj (svjetskoj) rusistici (slavistici).]]></summary_hr><summary_en><![CDATA[All surveys and critical studies state that studies into recent Russian literature are dispersed, with no poetic determinants. There is lack of research synthesis in the contemporary humanities, especially Russian and Slavic studies. This project proposal focusing on Russian literary transformations in the 1990-2020 period aims at solving divergence and unstructured nature of the current research with scientific and analytical means by identifying, classifying, describing and explaining analytically the existent trends and tendencies in the stated period. The project proposal focusing on Russian literary transformations in the 1990-2020 period has a clear theoretical framework based on the presumption about the importance of the starting point (1990) because it signals a cultural, historical and political milestone, while the importance of the final year, i.e. 2020 and the end of the decade, is important because it is the closest point to contemporaneity in line with the most recent literary trends of “the now and here”. We believe that, based on the previous findings and future studies, we will be able to clearly show changes in the poetic system from 1990 to 2010, as well as a new poetic turning point in the period from 2010 onwards. The project is important for local and global community. Locally, because we are interested in the trends in Russian literature in the context of specific Russian literary and cultural traditions, and globally, because we intend to combine our research with global trends in the development of literary studies. This will enable us to offer further guidelines for studying contemporary Russian literature as a world phenomenon. Such a comprehensive research of Russian literatures has not been performed by Croatian, Russian or European (global) Russian and Slavic studies scholars.]]></summary_en></project><project>
<id>9909</id><title_hr><![CDATA[Multi-fizikalno modeliranje površinskih i podzemnih voda]]></title_hr><title_en><![CDATA[Multiphysics modelling of surface-subsurface water systems]]></title_en><user_id>6687</user_id><user_firstLast_name>Hrvoje Gotovac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2020-02</proposal_call><code>IP-2020-02-2298</code><acronim><![CDATA[Multi-waters ]]></acronim><duration>01.01.2021 - 30.04.2025</duration><status>Završio</status><financ_value>193.748,76 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Građevinarstvo, Temeljne tehničke znanosti, Interdisciplinarne tehničke znanosti, </scie_field_hr><scie_field_en>Civil engineering, Basic engineering sciences, Interdisciplinary technological sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu Fakultet građevinarstva, arhitekture i geodezije]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Civil Engineering, Architecture and Geodesy]]></institution_en><team_members_id>6169, 855295, 855296, 6989, </team_members_id><team_members_names><![CDATA[Vedrana Kozulić, Krste Živković, Marin Zelenika, Blaž Gotovac, ]]></team_members_names><keywords_hr><![CDATA[Multifizika, numeričko modeliranje, računalne metode, interakcija površinskih i podzemnih voda, tečenje i pronos, traser testovi, verifikacija]]></keywords_hr><keywords_en><![CDATA[Multiphysics, numerical modelling, computational methods, surface-subsurface interaction, flow and transport, tracer tests, laboratory verification]]></keywords_en><summary_hr><![CDATA[Novi inženjerski problemi i razvoj novih tehnologija uključuju različite fizikalne procese i pojave, poznate kao Multifizika. U ovom su projektu procesi interakcije površinskih i podzemnih voda odabrani kao reprezentativni primjeri Multifizike u složenim vodnim sustavima. Analize ovih multifizkalnih procesa toka i pronosa obično zahtijevaju 3-D paralelne numeričke simulacije  s velikm brojem nepoznanica i visoko paralelizirane računalne kodove, uključujući adaptivne više-rezolucijske metode u prostoru i vremenu. Poseban problem je pronalaženje odgovarajuće strategije povezivanja između domena s različitim fizikalnim pojavama, kao i verifikacija samih algoritama. Glavni cilj ovog projekta je razvoj novih paralelnih algoritama temeljenih na Fup baznim funkcijama i adaptivnim metodama kontrolnih volumena (postojećih i novih) za rješavanje složenih problema interakcije površinskih i podzemnih voda. U ovom projektu ćemo koristit klasičnu formulaciju kontrolnih volumena u otovrenom kodu PFLOTRAN i novu razvijenu izogeometrijsku formulaciju nazvanu CV-IGA, a koja je razvijena s naše strane. Razvijene metode i novi algoritmi implementirat će se u otvorene paralelne kodove: (1) generička paralelna biblioteka PETSc, (2) nestrukturirani klasični konačni volumeni - kod PFLOTRAN. Poseban doprinos projektu je verifikacija razvijenih algoritama korištenjem kontroliranih laboratorijskih eksperimenata u novom Hydrolab-u na Sveučilištu u Splitu. Primjena novih algoritama u PFLOTRAN-u i PETSc može biti relevantna za ekološko i ekološko modeliranje analizirajući utjecaj različitih aspekata na eko-sustav, kvalitetu vode, transport zagađenja, prodor slane vode u obalna područja, klimatsko modeliranje ili hidro-energiju. Rezultati projekta i razvijeni algoritmi poslužit će kao platforma za daljnju primjenu na različite multifizičke probleme, EU projekte i druge srodne fondove, uključujući poslovni sektor.]]></summary_hr><summary_en><![CDATA[Novel engineering problems and development of new technologies involve diverse physical processes and phenomena, known as Multiphysics. In this project, surface-subsurface flow and transport processes are chosen as representative examples of Multiphysics in water complex systems.  Surface-subsurface processes usually require large-scale 3-D parallel numerical simulations and highly parallelizable computer codes, including adaptive multiresolution methods in space and time. A particular problem is finding appropriate coupling strategy between domains with different physics phenomena as well as verification of large-scale Multiphysics algorithms. The main objective of this project is to develop novel parallel Multiphysics coupling algorithms based on Fup basis functions and control volume methods for solving of complex Multiphysics water problems. Particularly, we will use common control volume formulation based on open code PFLOTRAN and novel adaptive Fup multiresolution control volume isogeometric analysis (CV-IGA) developed by our numerical group. The developed methods and new algorithms will be implemented into the parallel open sources codes: (1) generic parallel library PETSc and (2) PFLOTRAN unstructured finite volume code for surface-subsurface interactions. Particular project contribution is verification of developed algorithms using controlled laboratory experiments in new Hydrolab in University of Split. Application of new algorithms in PETSc and PFLOTRAN can be relevant for environmental and ecological modeling analyzing impact of different aspects on eco-system, water-quality, pollution transport, saltwater intrusion in coastal regions, climate modeling or hydro-power energy. Project results and developed algorithms will be served as platform for further application to different Multiphysics problems, EU projects and other related funds including business sector.]]></summary_en></project><project>
<id>9910</id><title_hr><![CDATA[Stvaranje europskih identiteta – hrana, tekstil i metali u željeznom dobu između Alpa, Panonije i Balkana]]></title_hr><title_en><![CDATA[Creation of European Identities – Food, Textiles and Metals in the Iron Age Between Alps, Pannonia and Balkans ]]></title_en><user_id>3432</user_id><user_firstLast_name>Hrvoje Potrebica</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2020-02</proposal_call><code>IP-2020-02-2371</code><acronim><![CDATA[IronFoodTexMet]]></acronim><duration>18.01.2021 - 17.01.2025</duration><status>Završio</status><financ_value>119.143,61 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Arheologija, Interdisciplinarne humanističke znanosti, </scie_field_hr><scie_field_en>Archeology, Interdisciplinary humanities, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>27060, 12742, 25275, 12982, 19792, 29480, 12745, 29461, 27071, 865197, 867353, 867354, </team_members_id><team_members_names><![CDATA[Margarita Gleba, Andrijana Pravidur, Julia Katarina Fileš Kramberger, Renata Šoštarić, Mathias Mehofer, Lejla Bajramović, Petra Stipančić, Borut Križ, Karina Grömer, Luka Drahotusky-Bruketa, Laura Šejić, Damir Doračić, ]]></team_members_names><keywords_hr><![CDATA[željezno doba, identitet, hrana, tekstil, metali, Alpe, Panonija, Balkan, Kaptol, Dolenjska, Donja Dolina]]></keywords_hr><keywords_en><![CDATA[Iron Age, identity, food, textile, metals, Alps, Pannonia, Balkans, Kaptol, Dolenjska (lower Carniola), Donja Dolina ]]></keywords_en><summary_hr><![CDATA[Ovaj projekt ima za cilj utvrditi formativne elemente identiteta željeznodobnih zajednica na prostoru koji je kao ključna karika povezuje tri velike kulturne zone u Europi: središnju Europu, Sredozemlje i istočnu Europu. Upravo takav položaj čini ovaj relativno mali prostor izuzetno važnim za razumijevanje procesa stvaranja i promjene identiteta u daleko širim europskim okvirima. Iz kompleksa čimbenika koji tvore identitet prapovijesnih zajednica ovaj projekt izdvaja tri: hranu, tekstil i metale. Iako su prve dvije kategorije elementarne životne potrebe, krećemo od hipoteze da način njihova zadovoljavanja predstavlja izbor koji određuje način života željeznodobnih zajednica i stoji u jakoj korelaciji s njihovom percepcijom svijeta i vlastitog identiteta. S druge strane, metali, prvenstveno bronca i željezo, bili su temeljna pokretačka snaga za uspostavu kontakata i komunikaciju između različitih kulturnih skupina što omogućava kulturni transfer i promjene identiteta pojedinih zajednica. Istraživanje ćemo provesti u tri glavna smjera. Za komparativnu studiju materijalne kulture, prvenstveno metalnih predmeta izdvojena su tri ključna nalazišta na ovom prostoru na kojima ćemo provesti sustavnu komparativnu i kontekstualnu analizu: Kapiteljska njiva u Dolenjskoj, Kaptol u Požeškoj kotlini i Donja Dolina na obali Save. Istraživanje tekstila kao kompleksnog društvenog i gospodarskog fenomena temeljit će se na dvije kategorije materijala: neposredni materijalni ostaci tekstila i alati za proizvodnju tekstila. Rekonstrukcijom čitavog procesa, od proizvodnje tekstila, preko izrade tkanina, do rekonstrukcije nošnje dat ćemo osnovne značajke identiteta pojedinih zajednica te ustanoviti je li kategorija kulturnih skupina doista utemeljena na identitetu. Do istog cilja pokušat ćemo doći i rekonstrukcijom proizvodnje, prerade i pripreme hrane, temeljem dostupnih arheobotaničkih ostataka, analize ostataka iz strukture i s površine keramičkih posuda i analiza stabilnih izotopa.]]></summary_hr><summary_en><![CDATA[The aim of the project is to identify formative elements of the identity of Iron Age communities which occupied a region that played a key role in linking three large European cultural areas: Central Europe, Eastern Europe and the Mediterranean. It is precisely its position that makes this region crucial for our understanding of the processes of creation and alteration of identities in European context. Of the multitude of factors making up the identity of prehistoric communities, the project will focus on three: food, textile and metal. Although the first two are basic life needs, our hypothesis is that the way in which those needs are fulfilled reflects a choice which determined the way of life of the Iron Age communities, and is strongly correlated with their perception of the world and of their own identities. On the other hand, metals were driving force behind setting up contacts and communication among diverse cultural groups, which paved the way for cultural transfer and alteration of identities of individual communities. The research will go in three main directions. Three outstanding archaeological sites have been selected for the purpose of a contextual analysis and comparative study of material culture, primarily objects made of metal: Kapiteljska Njiva, Kaptol, and Donja Dolina. The investigation of textile will be conducted on two categories of finds: direct material remains of fabrics, and tools for textile production. The reconstruction of the entire process, spanning from the production of yarn, weaving of cloth, to the reconstruction of costume, will reveal some basic features of the identity of individual communities and determine whether the category of cultural groups is indeed based on identity. To achieve this we will also use reconstruction of the production, processing and preparation of food, using the available archaeobotanic remains, analyses of traces identified within the pottery structure and on its surface, and stable isotope analysis.]]></summary_en></project><project>
<id>9917</id><title_hr><![CDATA[PRirodA kao SAVEZnik: Strane  biljne invazivne vrste kao izvor farmaceutika  ]]></title_hr><title_en><![CDATA[NATURe as an ALLY: Alien invasive plants as phytopharmaceuticals ]]></title_en><user_id>6513</user_id><user_firstLast_name>Danijela Poljuha</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2020-02</proposal_call><code>IP-2020-02-6899</code><acronim><![CDATA[NATURALLY]]></acronim><duration>29.01.2021 - 22.06.2025</duration><status>Završio</status><financ_value>167.297,10 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Biotehnologija, </scie_field_hr><scie_field_en>Biotechnology, </scie_field_en><institution_hr><![CDATA[Institut za poljoprivredu i turizam]]></institution_hr><institution_en><![CDATA[Institute of Agriculture and Tourism in Poreč]]></institution_en><team_members_id>6570, 19316, 5997, 26738, 26745, 27326, 23648, 17895, 865029, 28663, </team_members_id><team_members_names><![CDATA[Ivana Šola, Josipa Bilić, Barbara Sladonja, Slavica  Dudaš, Maja Mikulič Petkovšek, Jacobus Eloff, Roberta Petlevski, Ida Linić, Mirela Uzelac, Ivana Pavičić, ]]></team_members_names><keywords_hr><![CDATA[strane invazivne vrste, biljke, ekstrakti, fitofarmaceutici, fenolni profil, biološka aktivnost, usluge ekosustava]]></keywords_hr><keywords_en><![CDATA[invasive alien species, plants, extracts, phytopharmaceuticals, phenolic profile, biological activity, ecosystem services]]></keywords_en><summary_hr><![CDATA[Ekstrakti mnogih biljnih vrsta sadrže značajne bioaktivne spojeve, stoga bi uporaba odgovarajućih biljnih ekstrakata mogla dovesti do razvoja novih, jeftinih i ekološki prihvatljivih farmaceutskih proizvoda baziranih na lokalnim prirodnim izvorima. Invazivne vrste predstavljaju jednu od najvećih  globalnih prijetnji bioraznolikosti. Introducirane vrste mogu postati invazivne i potisnuti autohtone vrste, utjecati na procese i funkcioniranje ekosustava, ometati pružanje usluga ekosustava te uzrokovati značajne ekonomske gubitke. Međutim, i domaće i introducirane vrste imaju značajnu društvenu, gospodarsku, krajobraznu i ekološku vrijednost i pružaju niz usluga ekosustava. Potencijal invazivnih biljnih vrsta je osim njihove moguće uporabe kao izvora farmaceutski aktivnih spojeva i u njihovoj dostupnosti u velikim količinama. Glavni cilj ovog projekta je istražiti fitofarmaceutski potencijal prirodnih ekstrakata četiri strane invazivne biljne vrste (SIBV) u Istri (Hrvatska), kao osnovu za nove moguće usluge ekosustava. To se planira postići ostvarivanjem sljedećih specifičnih ciljeva: kemijsko profiliranje ekstrakata SIB vrsta tekućinskom kromatografijom – spektrometrijom mase (LC-MS); određivanje antioksidacijskih, antimikrobnih, antiproliferativnih, genotoksičnih i citotoksičnih svojstava ekstrakata SIB vrsta i izoliranih specifičnih frakcija funkcionalnim testovima; procjena potencijala SIB vrsta za primjenu u fitofarmaciji; prijedlog modela za iskorištavanje novih (medicinskih) usluga ekosustava koje pružaju SIB vrste na pilot području Istre (Hrvatska). Projekt će stvoriti nova znanja vezana uz biofarmaceutski potencijal SIB vrsta, što će potencijalno pridonijeti razvoju hrvatskog bioekonomskog sektora, kao i globalnom zdravlju i kvaliteti života. Uz to, kroz realizaciju projekta uspostavit će se nove suradnje između nacionalnih i međunarodnih istraživačkih timova.]]></summary_hr><summary_en><![CDATA[Extracts of many plant species have substantial bioactive compounds; therefore the use of plant extracts with good activity could lead to the development of new inexpensive and environmentally acceptable pharmaceutical products based on locally available natural resources. Invasive species are recognized as one of the largest global threats to biodiversity. Introduced species may become invasive and displace native species, affect ecosystem processes and functioning, and cause substantial economic losses. On the other hand, both native and non-native species have enormous social, economic, landscape, and ecological importance and provide a number of ecosystem services. The potential of invasive species is in their possible use as a source of pharmaceutically active compounds, and also in their availability in large quantities. The general objective of this project is to explore the potential of natural extracts of four most widespread alien invasive plant species (IAPS) in Istria (Croatia) for the application as phytopharmaceuticals, as a basis for a new possible ecosystem service provided by IAPS. It will be accomplished through the achievement of the following specific objectives: chemical profiling of IAPS extracts by liquid chromatography–mass spectrometry (LC-MS); determination of antioxidative, antimicrobial, antiproliferative, genotoxic and cytotoxic properties of IAPS extracts and isolated specific fractions by functional tests; the estimation the IAPS potential for the application in phytopharmacy; the proposal of the model for exploring new IAPS provisioning (medicinal) ecosystem services on the pilot territory of Istria (Croatia). The project will create new knowledge related to biopharmaceutical potential of IAPS, which will potentially contribute to the development of Croatian bio-economy sector as well as global health and quality of life. Moreover, new connections between national and international research teams will be established.]]></summary_en></project><project>
<id>9922</id><title_hr><![CDATA[Utjecaj valova vezanih uz otok na primarnu produkciju ]]></title_hr><title_en><![CDATA[Island trapped waves as a driver of primary production]]></title_en><user_id>2829</user_id><user_firstLast_name>Zrinka Ljubešić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2020-02</proposal_call><code>IP-2020-02-9524</code><acronim><![CDATA[ISLAND]]></acronim><duration>01.02.2021 - 24.06.2025</duration><status>Završio</status><financ_value>165.571,70 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Interdisciplinarne prirodne znanosti, Fizika, Kemija, Biologija, Geofizika, </scie_field_hr><scie_field_en>Interdisciplinary natural sciences, Physics, Chemistry, Biology, Geophysics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>23559, 4337, 23569, 23577, 17842, 3375, 3277, 25812, 25817, 2843, 23438, 865208, 869823, </team_members_id><team_members_names><![CDATA[Eric Pieter Achterberg, Sunčica Bosak, Hrvoje Čižmek, Barbara Čolić, Maja Mucko, Mirko Orlić, Davor Lučić, Branka Pestorić, Melissa  Omand, Damir Viličić, Raffaella Casotti, Antonija Matek, Filip Grgurević, ]]></team_members_names><keywords_hr><![CDATA[valovi vezani uz otok, primarna produkcija, fizikalo-biološka interakcija, plankton, bentos]]></keywords_hr><keywords_en><![CDATA[island-trapped waves, primary production, physico-biological coupling, plankton, benthos]]></keywords_en><summary_hr><![CDATA[Valovi vezani uz otok (engl: Island-trapped waves ITWs) su tip valova vezanih uz obalu (engl: coastal-trapped waves CTWs), dobro poznat i značajan oceanografski fenomen koji utječe na vertikalne pomake piknokline, i time na  miješanje vodenog stupca, transport hranjivih tvari te na dinamiku primarne produkcije. Pretpostavljamo da je ITW glavni pokretač primarne produkcije u vrijeme stratifikacije u oligotrofnim vodama Lastovskog arhipelaga. Da bismo testirali ovu hipotezu, predlažemo interdisciplinarno istraživanje u kojemu će se koristiti razne metode i senzori sa ciljem povezivanja ITW s resupenzijom hranjivih soli i primarnom produkcijom. Dodana vrijednost predloženom projektu, te dodatna podrška za testiranje hipoteza je analiza bentičke zajednice koju će se napraviti pomoću ronioca i ROV-a. Dinamiku primarne produkcije povezat ćemo sa vremenski i prostorno gustim setom podataka dobivenih biogeokemijskim senzorima pričvršćenih uz podmorske litice Lastova (klorofil a, turbiditet, fotosinteska aktivna radijacija i hranjive soli) i usidrenog sustava Wirewalker – instrumenta koji profilira od dna do površine te mjeri brojna hidrografska i bio-optička svojstava mora. Neto primarna proizvodnja (NPP) izračunat će se iz dnevnih ciklusa oslabljenja radijacije čestica i koncentracije kisika. Odredit će se sastav zajednice i abundancija primarnih i sekundarnih producenata s više metoda (svjetlosna i elektronska mikroskopija, protočna citometrija, sekvencioniranje slijedeće generacije). Predloženo interdisciplinarno istražvanje će povezati primarnu produkciju sa ITW, te finu vremnesku i prostornu rezoluciju fizikalno kemijskih podataka sa bentičkom zajednicom što do sada nije bilo napravljen u ovdje predloženom obimu.]]></summary_hr><summary_en><![CDATA[Island-trapped waves (ITWs) are a special case of coastal-trapped waves (CTWs); a well-known oceanographic phenomenon. Vertical pycnocline movements related to CTWs impact vertical mixing, transport of nutrients and primary production. We hypothesize that ITWs fuel up the primary production in the stratification period in the oligotrophic waters of Lastovo archipelago. To test this hypothesis we propose an interdisciplinary research program, that will provide insights into the physical-biological coupling on much finer scale than achieved before; using biogeochemical sensors mounted to steep underwater cliffs of the island (chlorophyll a, turbidity, photosynthetic active radiation and nutrients) in addition to hydrographic sensors and a moored WireWalker - buoyant instrument platform clipped to a wire profiling from surface buoy to near the seafloor, equipped with various oceanographic sensors. In support of the high-resolution moored measurements, discrete ship-based sampling for nutrients, primary and secondary producers will also be performed, as well as continues analyses  of the state of the benthic community using photographic quadrants. Primary productivity will be assessed from diel cycles in bio-optical properties both from the Wirewalker, as well as from ship based measurements during the stratification and period of water column mixing. Observations that elucidate primary production dynamics will be augmented by high resolution records of temperature, light intensity, chlorophyll a and nutrients from sensors. To determine the primary and secondary producers multiple tools will be used (light and electron microscopy, flow-cytometry, NGS). With proposed interdisciplinary research we will link ITWs to NPP as well as the detailed physico-chemical high resolution data to benthic community, which has not been done before in this extent. ]]></summary_en></project><project>
<id>9925</id><title_hr><![CDATA[Inovativna rješenja za racionalizaciju upotrebe bentonita u postizanju proteinske stabilnosti bijelih vina]]></title_hr><title_en><![CDATA[Innovative solutions for rationalising the use of bentonite in white wine protein stabilisation]]></title_en><user_id>4924</user_id><user_firstLast_name>Igor Lukić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2020-02</proposal_call><code>IP-2020-02-4551</code><acronim><![CDATA[INNOSTAB]]></acronim><duration>15.01.2021 - 14.07.2025</duration><status>Završio</status><financ_value>161.006,04 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Prehrambena tehnologija, Poljoprivreda, </scie_field_hr><scie_field_en>Food technology, Agriculture, </scie_field_en><institution_hr><![CDATA[Institut za poljoprivredu i turizam]]></institution_hr><institution_en><![CDATA[Institute of Agriculture and Tourism in Poreč]]></institution_en><team_members_id>21020, 26936, 7171, 26686, 26064, 13660, 1052, 29454, 6511, 865023, 869660, </team_members_id><team_members_names><![CDATA[Ivana Horvat, Ivana Rajnović, Urska Vrhovsek, Katja Suklje, Ana Hranilovic, Tomislav Plavša, Ana Butorac, Marina Markeš, Sanja Radeka, Doris Delač Salopek, Lucija Sobotinčić, ]]></team_members_names><keywords_hr><![CDATA[proteinska stabilnost vina, proteini povezani s patogenezom, bentonit, bistrenje vina, kvaliteta vina, metabolomika, proteomika, Malvazija istarska]]></keywords_hr><keywords_en><![CDATA[wine protein stability, pathogenesis-related proteins, bentonite, wine fining, wine quality, metabolomics, proteomics, Malvazija istarska]]></keywords_en><summary_hr><![CDATA[Bijela vina s razvijenim proteinskim zamućenjem koje potječe od agregacije tzv. proteina povezanih s patogenezom (PR proteini) nisu utrživa. Standardni, općeprihvaćeni postupak za prevenciju proteinskog zamućenja je uklanjanje proteina adsorpcijom na bentonit prije punjenja u boce, kojeg, međutim, odlikuju bitni nedostaci, uključujući gubitke količina i kvalitete vina. Do danas predložene alternative bentonitu uglavnom su se pokazale nepraktičnim, skupim, s različitim negativnim nuspojavama, još uvijek su na razini istraživanja ili su pokušaji obustavljeni, te nisu dopuštene legislativom EU. Glavni cilj ovog Projekta je razvoj inovativnih tehnoloških rješenja za smanjenje potrebne količine bentonita, uz očuvanje ili poboljšanje kvalitete vina. Ciljevi uključuju: (1) poboljšanje proteinske stabilnosti vina regulacijom parametara u berbi i pred-fermentativnoj preradi grožđa, (2) umanjenje koncentracije PR proteina fermentacijom s nekonvencionalnim kvascima, (3) umanjenje potrebne doze bentonita iskorištenjem komplementarnih afiniteta bentonita i drugih enoloških sredstava prema PR proteinima te (4) istraživanje uzroka potreba za velikim količinama bentonita u bistrenju bijelog vina kultivara Malvazija istarska. Istraživanje će se provesti kroz niz tehnoloških pokusa podržanih snažnom analitičkom platformom, uključujući konvencionalne instrumentalne analize nadopunjene sveobuhvatnom proteomikom i metabolomikom, za koje se očekuje da će proizvesti originalne i napredne podatke objavljive u znanstvenim časopisima visokog faktora odjeka. Predložena rješenja u skladu su s trenutačnim zakonodavnim okvirom, ekonomski su izvediva i ekološki održiva, ne uključuju dodatna kapitalna ulaganja te bi se mogla praktično usvojiti bez odgode. Time bi se proizvođačima omogućila proizvodnja većih količina kvalitetnijeg vina te jačanje njihove konkurentnosti na tržištu, što bi moglo pozitivno utjecati na opću kvalitetu života u gospodarstvima s vinarskom proizvodnjom.]]></summary_hr><summary_en><![CDATA[White wines with developed protein haze/sediment, originating from the aggregation of pathogenesis-related (PR) grape proteins, are not marketable. The current practice to prevent protein haze is to remove proteins before bottling by adsorption onto bentonite, which has several drawbacks, including losses in wine quantity and quality. Alternatives to bentonite proposed up to date mostly lacked practicality and exhibited technical shortcomings or negative side-effects, and are still on research level or discontinued, and not allowed by EU legislation. The main goal of the Project is to develop innovative technological solutions for reducing the required amount of bentonite, at the same time preserving or improving wine quality. The objectives include: (1) improving wine protein stability by regulating grape harvest and pre-fermentative processing parameters, (2) reducing the concentration of PR proteins by fermentation with nonconventional yeasts, (3) reducing bentonite dose by exploiting complementary affinities of bentonite and other oenological agents towards PR proteins, and (4) investigation of the causes of high bentonite requirements of Malvazija istarska white wine. The research will be conducted through a series of technological experiments supported by a strong analytical platform comprising conventional instrumental analyses complemented by comprehensive proteomics and metabolomics, which are expected to generate cutting-edge novel data publishable in most reputable scientific journals. The solutions proposed are in line with the current legislative setting, are economically feasible and environmentally viable, do not include additional capital investments and labour, and could be readily commercially adopted. This would allow producers to obtain larger quantities of higher quality wine, and in this way strengthen their competitiveness on the market, which could have positive impact on the general quality of life in winemaking economies.]]></summary_en></project><project>
<id>9926</id><title_hr><![CDATA[ESTETSKO OBRAZOVANJE PUTEM NARATIVNE UMJETNOSTI I NJEGOVA VAŽNOST ZA HUMANISTIKU]]></title_hr><title_en><![CDATA[AESTHETIC EDUCATION THROUGH NARRATIVE ART AND ITS RELEVANCE FOR THE HUMANITIES]]></title_en><user_id>3814</user_id><user_firstLast_name>Iris  Vidmar Jovanović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2020-02</proposal_call><code>UIP-2020-02-1309</code><acronim><![CDATA[AEtNA]]></acronim><duration>01.02.2021 - 31.01.2026</duration><status>U tijeku</status><financ_value>159.704,96 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Interdisciplinarne humanističke znanosti, Filozofija, Povijest umjetnosti, Znanost o umjetnosti, </scie_field_hr><scie_field_en>Interdisciplinary humanities, Philosophy, Art history, Arts, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Filozofski fakultet u Rijeci]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>29467, 29468, 29557, 23262, 867510, 867597, </team_members_id><team_members_names><![CDATA[Rafe  McGregor, Mario Slugan, Joerg Fingerhut, David Grčki, Ema Luna Lalić, David Collins, ]]></team_members_names><keywords_hr><![CDATA[Narativna umjetnost, estetski kognitivizam, estetsko obrazovanje, humanističke znanosti i obrazovanje, vrijednosti ]]></keywords_hr><keywords_en><![CDATA[Narrative Art, Aesthetic Cognitivism, Aesthetic Education, Humanities, Values]]></keywords_en><summary_hr><![CDATA[Glavni je cilj ovoga istraživanja utemeljiti teoriju o epistemičkim i etičkim doprinosima narativne umjetnosti za pojedinca i društvo i na tim osnovama doprinijeti nastojanjima humanistike da utemelji svoju vrijednost u kontekstu sve veće kritičnosti prema humanističkim znanostima i obrazovanju. Polazimo od teze da bavljenje narativnom umjetnošću doprinosi razvoju pojedinca kao epistemičkog i etičkog djelatnika i tu tezu proširujemo na javnu domenu i tvrdimo da narativna umjetnost ima pozitivan utjecaj u domeni obrazovanja, kulture i društva. S obzirom na tako definirane teze, ovo se istraživanje nalazi na raskrižju triju filozofskih tradicija: (1) estetski kognitivizam, koji tvrdi da je narativna umjetnost izvor istina i da može prenijeti znanje i druga kognitivno relevantna stanja; (2) estetsko obrazovanje, teorija koja tvrdi da transformativne mogućnosti estetskoga iskustva doprinose moralnome razvoju; i (3) obrana vrijednosti humanistike (humanističkih znanosti i humanistički usmjerenoga obrazovanja, odnosno obrazovnih sadržaja  koji prepoznaju značaj umjetnosti i predmeta povezanih s umjetnošću). Svako od ovih triju glavnih područja ima svoje podrijetlo u takozvanom sukobu poezije i filozofije, odnosno u Platonovim izazovima obrazovnoj vrijednosti umjetnosti, posebno poeziji i dramskoj umjetnosti, i upravo je to naše polazište. Naš je cilj odgovoriti na Platonove izazove iz perspektive suvremenih stajališta o narativnoj umjetnosti (što uključuje književne forme, filmove, televizijske serije i kazalište), pri čemu te perspektive uzimaju u obzir tradiciju analitičke filozofije, umjetničke prakse i kognitivne znanosti. ]]></summary_hr><summary_en><![CDATA[The main aim of this research is to develop a theory of epistemic and ethical contribution of narrative art to the individual and to society and relate such a theory to the contemporary efforts of the humanities to defend their values in the face of rapidly growing criticism regarding humanistic education. We claim that engagements with narrative art influence individual’s cognitive capacities and moral sensibilities, and we extend this thesis to the public sphere and claim that narrative art makes a positive contribution to education, culture, and society. Given such theoretical commitment, this research lies at the intersection of three philosophical traditions: (1) aesthetic cognitivism, which claims that narrative art is a source of truth, capable of transferring knowledge and other cognitively relevant states; (2) aesthetic education, a theory which claims that transformative power of aesthetic experience contributes to one’s ethical development; and (3) the defence of the value of the humanities and humanistic education (i.e. the one that recognizes the relevance of art and art-related subjects). Each of the three main domains of our interest can be traced back to the ‘ancient quarrel’ and Plato’s challenges to the educational value of art, primarily poetry and dramatic works, which is our starting point. Our aim is to address Plato’s challenge from the perspective of contemporary views on narrative art (including literary forms, film, TV series and theatre), where such views are informed by analytic philosophical tradition, artistic practices and cognitive sciences.]]></summary_en></project><project>
<id>9929</id><title_hr><![CDATA[Struktura i funkcija mikrobnih zajednica kao karika koja nedostaje pri procjeni stanja okoliša u obalnim zonama pod antropogenim opterećenjem]]></title_hr><title_en><![CDATA[Structure and function of microbial communities as a missing link for quality assessment of anthropogenically disturbed coastal zones]]></title_en><user_id>5324</user_id><user_firstLast_name>Ines Sviličić Petrić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2020-02</proposal_call><code>IP-2020-02-6510</code><acronim><![CDATA[MicroLink]]></acronim><duration>01.03.2021 - 28.07.2025</duration><status>Završio</status><financ_value>159.293,91 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Interdisciplinarne prirodne znanosti, Matematika, Geologija, Kemija, Biologija, </scie_field_hr><scie_field_en>Interdisciplinary natural sciences, Mathematics, Geology, Chemistry, Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>6017, 25890, 26149, 3584, 434, 26628, 26161, 865099, 867213, 855403, 869784, </team_members_id><team_members_names><![CDATA[Slavica Matijević, Zlatan Morić, Vladimir Kuzmanovski, Martina Furdek Turk, Maja Fafanđel, Dimitrios Karpouzas, Antonis Chatzinotas, Ana Ramljak, Sotirios Vasileiadis, Marta Zizek, Anastazija Huđ, ]]></team_members_names><keywords_hr><![CDATA[bioindikator, DSO, mikrobne zajednice, bentos, struktura, funkcija, katabolički geni, ekološko stanje okoliša, onečišćenje, luke, Jadran]]></keywords_hr><keywords_en><![CDATA[bioindicator, GES, microbial community, sediment, structure, function, catabolic gene, ecological quality, anthropogenic pollution, harbours, Adriatic]]></keywords_en><summary_hr><![CDATA[Morski okoliši danas su kontinuirano podvrgnuti snažnim utjecajima višestrukih antropogenih pritisaka. U svrhu očuvanja ekosustava Sredozemlja i Jadrana, kao nosioca iznimne biološke raznolikosti, Mediteranske zemlje potpisale su stoga niz inicijativa i Direktiva. Kombinirajući i integrirajući različite pristupe koje proizlaze iz potisanih inicijativa, učinjeni su znatni pomaci za očuvanje ovih ekosustava, no ipak, programi zaštite morskog okoliša još uvijek se suočavaju s mnogim izazovima. MicroLink projekt usmjeren je na istraživanje mikrobne komponente morskih ekosustava, potpuno zanemarene u kontekstu Direktiva, a vođen je idejom da upravo mikrobne zajednice mogu ponuditi rješenje za neke od izazova programa zaštite morskih ekosustava: (i) izazov utvrđivanja utjecaja višestrukih stresora na stanje morskog okoliša, (ii) mogućnost nadogradnje postojećih bioloških pokazatelja uvođenja “novih” indikatorskih elemenata, (iii) potencijal korištenja brzih i pouzdanih suvremenih molekularnih alata pri procjeni stanja okoliša te (iv) problem vezan uz procjenu stanja bentoske komponente ekosustava. Mikroorganizmi čine dominantnu frakciju morskih ekosustava te igraju ključnu ulogu u biogeokemijskim ciklusima kruženjima stoga je neminovno da će promjene inducirane na razini ovih zajednica imati jak utjecaj na cjelokupnu hranidbenu mrežu. MicroLink je zamišljen kao multidisciplinarni projekt inovativnog pristupa koji integrira istraživanje mikrobnih zajednica na 4 različite trofičke razine (bakterije, arheje, gljive i virusi) koristeći 4 metodološka pristupa dajući nam uvid u ponašanje i dinamiku mikrobnih zajednica u zonama pod snažnim pritiscima ljudskih aktivnosti. Ovim projektom planira se odgovoriti na otvoreno pitanje o važnosti te doprinosu praćenja mikrobnih zajednica pri postizanju Dobrog Stanja Okoliša (DSO) time predstavljajući prvi korak pri potencijalnoj integraciji mikrobnih pokazatelja na listu bioloških pokazatelja ekološkog stanja morskog okoliša.]]></summary_hr><summary_en><![CDATA[With anthropogenically-driven pressures drastically changing marine coastal ecosystems much international efforts have been focused on its protection. For that reason, Mediterranean states have accepted numerous regional and international contracts. Even though much effort has been given into protection of marine ecosystems by combining and integrating approaches from WFD and MSFD, these tools are still facing many challenges. Within the frame of the MicroLink project we will focus on the anthropogenic pressures effects onto benthic microbial assemblages, fully neglected in the quality legislation protocols. We believed that microbial assemblages could offer potential answer to some of the challenges facing marine protection programmes: (i) challenge of determining effects of multiple pollution pressures on the integrity of the coastal marine ecosystem, (ii) possible improvement of the existing biological indicators pool (iii) potential of applying fast and reliable state-of-the-art approaches to determine structural and functional integrity of marine ecosystems; and (iv) problems associated with assessment of the ecological status of marine sediments. We will tackle the issue by an innovative approach in which we will combine multi-trophic (bacteria, archaea, virus, fungi)/ multilayer approach for studying microbial communities in anthropogenically-impacted vs. reference environments. Microbes dominate marine ecosystems and have pivotal role in biogeochemical cycling and consequently changes exerted on the level of these communities could alter the whole food web, eventually impairing marine ecosystem services. Within this project we intend to focus on an urgent need to define possible contribution and importance of monitoring microbial assemblages in achieving of Good Environmental Status (GES) which could offer us first step toward potential integration of microbial assemblages as indicators of marine environment quality.]]></summary_en></project><project>
<id>9930</id><title_hr><![CDATA[Povećanje konkurentnosti šumarskog sektora kroz razvoj kulture sigurnosti]]></title_hr><title_en><![CDATA[Increasing the competitiveness of forestry sector through development of safety culture]]></title_en><user_id>6163</user_id><user_firstLast_name>Matija Landekić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2020-02</proposal_call><code>IP-2020-02-7637</code><acronim><![CDATA[ForSaf2024]]></acronim><duration>11.01.2021 - 10.01.2025</duration><status>Završio</status><financ_value>113.044,26 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Šumarstvo, </scie_field_hr><scie_field_en>Forestry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet šumarstva i drvne tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Forestry and Wood Technology]]></institution_en><team_members_id>6692, 6175, 6025, 25516, 22506, 26209, 26095, 6153, 866640, </team_members_id><team_members_names><![CDATA[Ivan Martinić, Mario Šporčić, Zdravko Pandur, Matija Bakarić, Marin Bačić, Rosa M. Ricart, Anton Poje, Marijan Šušnjar, Josipa Nakić, ]]></team_members_names><keywords_hr><![CDATA[Šumarstvo, proizvodnja, standardi osposobljavanja, kultura sigurnosti, konkurentnost]]></keywords_hr><keywords_en><![CDATA[Forestry, production, training standards, safety culture, competitiveness]]></keywords_en><summary_hr><![CDATA[Šumska proizvodnja smatra se jednom od najopasnijih radnih aktivnosti s visokim udjelom ozljeda. Okolišni uvjeti, visoka opterećenja, učestalo korištenje ručnih alata i strojeva čini rad izrazito fizički i psihološki intenzivnim, a radnike izložene brojnim profesionalnim oboljenjima. Potrebna unapređenja mogu se postići kroz razvoj i usvajanje kulture sigurnosti kojom se utječe na stavove i način ponašanja radnika, pruža okvir za njihovo djelovanje i razmišljanje, smanjuje tjeskobu i time djeluje na razinu sigurnosti. Razvoj kulture sigurnosti u šumarstvu obuhvatiti će: analizu glavnih pokazatelja zaštite na radu i ocjenu postojećeg stanja, mjerenje buke i vibracija, ocjenu radne tehnike te fizičkog i posturalnog opterećenja radnika, razvoj postupka za utvrđivanje radne sposobnosti, analizu postojećih ustanova i programa osposobljavanja radnika, prijedlog nacionalnog standarda za osposobljavanje radnika te izradu strukovnog vodič s pravilima i primjerima najbolje prakse. Istraživanja će uključiti glavne dionike proizvodnog procesa u šumarstvu RH (Hrvatske šume d.o.o. i privatne izvoditelje radova), a lokaliteti za provedbu terenskih mjerenja odabrati će se putem slučajnog stratificiranog uzorka. Istraživački postupci obuhvatit će pregled literature, razvoj i provedbu anketnog upitnika te terenska mjerenja (buka i vibracije, ocjena radne tehnike Xsens tehnologijom, digitalna pulsmetrija, OWAS i REBA metoda). Očekivani rezultati, u obliku prijedloga nacionalnog standarda osposobljavanja šumskih radnika, strukovnog vodiča, web aplikacije za testiranje stručnoga znanja i dr., omogućiti će neophodno unapređenje sigurnosti u šumarstvu te pridonijeti konkurentnosti sektora. Isto je u skladu s &#39;Nacionalnom šumarskom politikom i strategijom&#39; te neposredno pridonosi &#39;Globalnim ciljevima održivoga razvoja do 2030.&#39;, certifikaciji upravljanja šumama, interesu i atraktivnosti šumarske profesije na tržištu rada te povećanju ukupne efikasnosti šumske proizvodnje u Hrvatskoj.]]></summary_hr><summary_en><![CDATA[Forest production is one of the most dangerous activities with a high degree of accidents and fatal injuries. Environmental conditions, high work load, frequent use of hand tools make the work physically and psychologically intense, and workers exposed to numerous occupational illnesses. Necessary improvements can be achieved through the development of a safety culture which influences attitudes and behavior of workers, provides a framework for their actions and thinking, reduces anxiety and thus affects the level of security. Development of safety culture includes: analysis of the main occupational safety indicators, noise and vibration measurement, evaluation of the working technique, physical and postural worker loads, development of procedure for determining work ability, analysis of the existing facilities and training programs, proposal of national standard for worker training, and vocational guide with best practice examples. The research will include the main stakeholders of the production process in Croatian forestry sector (Croatian Forests Ltd. and private entrepreneurs), and the localities for field measurements will be selected through a random stratified sample. Research activities include literature review, survey development and field measurements (noise and vibrations, evaluating work techniques using Xsens technology, heart rate method, OWAS and REBA method). Results, in the form of a proposal for national standard of forest workers training, a vocational guide, a web application for testing of professional knowledge, etc., will provide the necessary enhancement of forest safety and contribute to sector competitiveness. This is consistent with the &#39;National Forestry Policy and Strategy&#39; and directly contributes to the &#39;Global Sustainable Development Goals by 2030&#39;, certification of forest management, interest and attractiveness of the forestry profession on the labor market and increases the overall efficiency of forest production in the Croatia.]]></summary_en></project><project>
<id>9933</id><title_hr><![CDATA[Razvoj metoda matematičkog modeliranja u biologiji i medicini]]></title_hr><title_en><![CDATA[Methods developing in mathematical modelling in biology and medicine]]></title_en><user_id>570</user_id><user_firstLast_name>Miljenko Huzak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2020-02</proposal_call><code>IP-2020-02-9559</code><acronim><![CDATA[MethMathModBioMed]]></acronim><duration>01.02.2021 - 30.06.2025</duration><status>Završio</status><financ_value>91.313,29 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, Biologija, </scie_field_hr><scie_field_en>Mathematics, Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>3273, 1396, 577, 26157, 867522, 861499, </team_members_id><team_members_names><![CDATA[Inga Marijanović, Ivica Rubelj, Snježana Lubura Strunjak, Ana Martinčić Špoljarić, Nikolina Milinčević, Karla Ostojić, ]]></team_members_names><keywords_hr><![CDATA[difuzijski procesi, Markovljevi procesi, aproksimativni MLE, odabir modela, tumorski sferoidi, asimptotska distribucija, dizajn eksperimenta, telomeri]]></keywords_hr><keywords_en><![CDATA[diffusion processes, Markov processes, approximate MLE, model selection, tumor spheroids, asymptotic distribution, design of experiments, telomere]]></keywords_en><summary_hr><![CDATA[Iako su metode matematičkog modeliranja u biomedicine do sada znatno razvijene dosta je  problema koje još treba postaviti i riješiti matematički. Uobičajeno su ti problemi vezani uz istraživanje svojstava predloženog matematičkog modela, uz prilagodbu modela podacima i njegovog vrednovanja te upotrebe u biomedicini. Budući da su sve te faze u matematičkom modeliranju blisko vezane uz stvarne podatke i razumijevanje fenomena od interesa, posebno ćemo se fokusirati na tri problema: modeliranje rasta avaskularnih tumorskih sferoida, modeliranje skraćivanja telomera i modeliranje i procjenjivanje koreliranosti duljina telomera/aktivnosti telomeraze i stope rasta sferoida.  U modeliranju rasta sferoida planiramo proizvesti stvarne podatke, efikasno prilagoditi difuzijske procese rasta, izabrati najprihvatljiviji model i vrednovati ga. U tu svrhu moramo analizirati svojstva predloženih procjenitelja metodama stohastičke analize i matematičke statistike, koristiti metode primijenjene statistike za prilagodbu modela i vrednovanje, te dizajnirati i primijeniti testove za odabir modela i testiranje homogenosti sferoida. U modeliranju skraćivanja telomera planiramo odrediti i predložiti model baziran na difuzijama, analizirati razdiobe vremena iščeznuća telomera i stanica i dizajnirati statistički model za prilagodbu predloženog procesa skraćenja telomera. U tu svrhu koristi ćemo metode teorije slučajnih procesa, stohastičke analize i matematičke statistike. Teoremi koje planiramo dokazati su doprinosi u polju primijenjene matematike, posebno u primjeni slučajnih procesa, matematičkoj i primijenjenoj statistici.  Očekujemo da će ovo istraživanje imati utjecaja na poboljšanje predikcijskih modela za pacijente oboljele od raka, na primjenjivost sferoida u personaliziranoj medicini, te na razumijevanje procesa staničnog starenja.]]></summary_hr><summary_en><![CDATA[Although methods of mathematical modelling in biomedicine have been significantly developed so far still there are many problems that have to be addressed and solved mathematically.  These problems are usually related to research for properties of a proposed mathematical model, to fitting a model to data and its validation and use in biomedicine. Since all of these stages in mathematical modelling are closely related to real data and understanding of the phenomena of interest we will particularly focus on three problems: modelling of avascular tumour spheroid growth, modelling of telomere shortening, and modelling and estimating correlation of telomere length/telomerase activity and spheroid growth rate. In modelling tumour spheroids growth we plan to obtain real data, fit diffusion processes of growth efficiently, select the most acceptable model and validate it. For this purpose we need to analyse properties of proposed estimators by methods of stochastic analysis and mathematical statistics, to use applied statistics methodology for fitting model to data and its validation, and to design and apply tests for model selection and for testing homogeneity of spheroids. In modelling telomere shortening we plan to determine and propose diffusion based models, analyse distributions of telomere extinction time and cells, and design statistical model for fitting the proposed process of telomere shortening.  To do that we have to use methods of theory of random processes, stochastic analysis and mathematical statistics. Theorems that we plan to prove are improvements in the field of applied mathematics, particularly in application of random processes, mathematical and applied statistics. We expect that this research will have impacts on improving prediction models for cancer patients and applicability of tumour spheroids in personalized medicine, and in improving our understanding of cell aging processes.]]></summary_en></project><project>
<id>9934</id><title_hr><![CDATA[Transformiranje jadranskog kozmosa: otočnost, povezanost i glokalni identiteti predrimske Dalmacije]]></title_hr><title_en><![CDATA[Transforming the Adriatic cosmos: insularity, connectivity and glocalized identities of pre-Roman Dalmatia ]]></title_en><user_id>21192</user_id><user_firstLast_name>Marina Ugarković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2020-02</proposal_call><code>UIP-2020-02-2419</code><acronim><![CDATA[AdriaCos]]></acronim><duration>01.02.2021 - 31.01.2026</duration><status>U tijeku</status><financ_value>187.675,76 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Arheologija, Interdisciplinarne humanističke znanosti, </scie_field_hr><scie_field_en>Archeology, Interdisciplinary humanities, </scie_field_en><institution_hr><![CDATA[Institut za arheologiju]]></institution_hr><institution_en><![CDATA[Institute of Archaeology in Zagreb]]></institution_en><team_members_id>5152, 23684, 6400, 29457, 29458, 29447, 865081, 21180, 865193, 865312, 866663, 866656, 872716, </team_members_id><team_members_names><![CDATA[Martina Čelhar, Jelena Marohnić, Sara Popović, Lilian de Angelo Laky, Charles Barnett, Ivanka-Katya Kamenjarin, Pio Domines Peter, Antonela Barbir, Martina Korić, Eduard Visković, Marko Bibić, Rudolph Alagich, Lujana Paraman, ]]></team_members_names><keywords_hr><![CDATA[Mediteran/Jadran, protopovijest, antički Grci, lokalne zajednice, postkolonijalni pristup, materijalna kultura, prakse, interakcija, arheometrija]]></keywords_hr><keywords_en><![CDATA[Mediterranean/Adriatic, protohistory, ancient Greeks, local agency,  postcolonial studies, material culture, practice, interaction, archaeometry]]></keywords_en><summary_hr><![CDATA[Promišljajući o Jadranu kao geografskom i kulturnom prostoru oblikovanom društvenih akterima, projekt teži postavljanju novih temelja sagledavajući otočnost, povezanost i formiranje glokalnih identiteta  predrimske Dalmacije (posljednje tisućljeće pr. n. e., s fokusom na 4. - 1. st. pr. n. e.). Kao jedno od najdinamičnijih razdoblja u razvoju ove regije, njezina &#39;&#39;protopovijest&#39;&#39; obilježena je osnivanjem grčkih otočkih apoikija i njihovim kulturnim ispreplitanjem s lokalnim zajednicama. Projekt ima za cilj preispitati kulturno-povijesni narativ u kojemu se Grci promatraju kao &#39;&#39;superiorni&#39;&#39;, a lokalno stanovništvo kao &#39;&#39;pasivni primatelji&#39;&#39; u kulturnim razmjenama tijekom ovoga razdoblja, uzimajući u obzir suvremene teorijske perspektive u arheologiji i društvenoj antropologiji. Uklopljen je u opći postkolonijalni pristup i integrira pojmove isprepletenosti te perspektivu proučavanja aktivne uloge materijalne kulture tijekom njene proizvodnje i korištenja. Fokus će biti na otoku Hvaru, posebno na dvije njegove najveće zajednice, grčkoj koloniji Faru i lokalnom Hvaru, uspoređujući ih s drugim otočnim i kontinentalnim dinamičnim zajednicama. Ključni će se podaci prikupiti proučavanjem više međusobno povezanih aspekata materijalne kulture i društvene prakse, kao i primjenom inovativnih i najsuvremenijih interdisciplinarnih metodologija. Takav će se set podataka koristiti za stvaranje iznijansiranije interpretacije specifičnosti grčkih gradova u Dalmaciji, kao i za analizu raznolikih i složenih obrazaca korištenja i aproprijacije na dalmatinskim lokalitetima i osporavanje postojećih kulturno-povijesnih narativa o jednostranom &#39;&#39;širenju&#39;&#39; grčkih utjecaja. U  potrazi za odgovorom na to kako su kulturni predlošci selektivno usvojeni i adaptirani kako u „lokalnom“ tako i „kolonijalnom“ kontekstu, cilj ovog projekta jest provjeriti hipotezu da su Hvar i Dalmacija složene multikulturne zajednice u kojima su društveni akteri i materijalna kultura igrali različite aktivne uloge.]]></summary_hr><summary_en><![CDATA[Rethinking the Adriatic as a geographic and cultural space shaped by human agency, the project will break new ground by tracing insularity, connectivity and formation of glocalised identities in pre-Roman Dalmatia (the last Millennium BCE, with a focus on the 4th to the 1st c. BCE). As one of the most thriving periods in this region’s development, its ‘protohistory’, it is marked by the establishment of Greek island apoikies and their cultural entanglement with local communities. The project aims to scrutinize the culture-historical narrative of Greeks as ‘superior’ and locals as ‘passive’ recipients in cultural exchanges during this period, taking into account recent theoretical perspectives in archaeology and social anthropology. It is embedded within the general postcolonial approach, and integrates concepts of entanglement and material culture studies’ perspective on the different active roles of material culture during its production and consumption. The focus will be set on the island of Hvar, especially two of its biggest communities, that of colonial Pharos and local Hvar, contrasting them to other insular and continental transforming communities. Important data will be gained through the study of multiple interconnected aspects of material culture and social practice as well as novel and/or state-of-the-art interdisciplinary methodologies. These data will be used to provide a more nuanced interpretation of the specifics of Greek cities in Dalmatia as well as to analyse the various and complex consumption and appropriation patterns at Dalmatian sites and challenge the preexisting culture-historical narratives about the unilateral ‘spread’ of Greek influences. In its pursuit of an answer to how cultural templates were selectively adopted and adapted both in “local’’ and “colonial’’ contexts, this project aims to validate the hypothesis that Hvar and Dalmatia were complex cultural melting pots where agency and material culture played different active roles. ]]></summary_en></project><project>
<id>9935</id><title_hr><![CDATA[Priroda i odrednice sekstinga među adolescentima i mladima: Kros-kulturalno istraživanje  ]]></title_hr><title_en><![CDATA[Nature and determinants of sexting among adolescents and youth: A cross-national study]]></title_en><user_id>25476</user_id><user_firstLast_name>Arta Dodaj</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2020-02</proposal_call><code>UIP-2020-02-3553</code><acronim><![CDATA[SextYouth]]></acronim><duration>15.02.2021 - 14.02.2026</duration><status>U tijeku</status><financ_value>146.421,13 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Psihologija, Sociologija, Socijalne djelatnosti, Interdisciplinarne društvene znanosti, </scie_field_hr><scie_field_en>Psychology, Sociology, Social work, Interdisciplinary social sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zadru]]></institution_hr><institution_en><![CDATA[University of Zadar]]></institution_en><team_members_id>29296, 29343, 29402, 23383, 29460, 24137, 865287, 864939, 25867, </team_members_id><team_members_names><![CDATA[Ashton Speno, Mónica Ojeda Pérez, Katarina Šimić, Bruno Barać, Irena Pavela Banai, Barbara Herceg Pakšić, Krešimir Prijatelj, Marko Odak, Sabina Mandić, ]]></team_members_names><keywords_hr><![CDATA[seksting, odrednice, adolescencija, mlada odrasla dob, kros-kulturalno]]></keywords_hr><keywords_en><![CDATA[sexting, determinants, adolescent, early adulthood, cross-national]]></keywords_en><summary_hr><![CDATA[Razmjena seksualno eksplicitnoga sadržaja putem elektronskih medija ili seksting među mladima postaje sve prisutniji. Stoga ovoj pojavi znanstvenici i profesionalci poklanjanju sve veću pažnju. Znanstveni interes za seksting primarno je usmjeren prema razumijevanju učestalosti i posljedica na pojedinca. Kako se ovaj oblik ponašanja javlja prilično rano kod mladih, trenutno su istraživanja usmjerena i prema proučavanju činitelja koji utječu na njegov razvoj.  Teorijska razmatranja činitelja koji utječu na seksting nema mnogo, što je i razumljivo s obzirom da se tek u novije vrijeme krenulo sistematski proučavati područje sekstinga. Cilj ovog projekta je istražiti, prirodu, raširenost i odrednice sekstinga među adolescentima i mladim odraslima iz dviju različitih kultura. Integrirajući raznorodne empirijske podatke i postavke dosadašnjih teorija, očekujemo složenu prirodu sekstinga i snažnu ulogu psiholoških, kontekstualnih i bioloških faktora koji dovode do takvog ponašanja. U predloženom projektu koristiti ćemo kombinaciju kvalitativne (online fokus grupe) i kvantitativne istraživačke metodologije uz longitudinalno prikupljanje podataka multimedotskim pristupom (upitničke mjere, mjere trenutne procjene, neuropsihološke mjere i fiziološke mjere) na uzorku srednjoškolaca i odraslih iz Bosne i Hercegovine te Hrvatske. Očekujemo da će rezultati istraživanja provedenih u okviru ovog projekta unaprijediti naše spoznaje o sekstingu i njenim mehanizmima među kulturalno različitim uzrocima adolescenata i mladih, što će imati utjecaj na provođenje smislene javne politike. Također, očekujemo da će  rezultati istraživanja osim znanstvenih publikacija i diseminacije doprinijeti uključivanju istraživačke grupe u daljnje aktivnosti znanstvene suradnje.]]></summary_hr><summary_en><![CDATA[The exchange of sexually explicit content via electronic media or sexting among youth has become a common practice. Therefore, researchers and professionals began to give greater attention to this issue. Researchers have primarily been focused on sexting prevalence and its consequences. Early engagement of youth in sexting have encourage researchers to focus their interest and into the risk factors of sexting. There are small number of research studies of sexting risk factor using some theoretical framework, which is understandable given the fact that only recently has the systematic investigation of sexting begun. The aim of this project is to investigate the nature, prevalence and determinants of sexting among adolescents and youth adult from two different cultures. By integrating the diverse empirical data and assumptions of current theories, we expect the complex nature of sexting and the strong role of psychological, contextual, and biological factors that lead to such behavior. In the proposed project, we will use a combination of qualitative (online focus group) research methodology and quantitative research methodology with longitudinal data collection using a multimethod approach (questionnaires, ecological momentary assessment, neuropsychological measures and physiological measures) in a sample of high school and adult students from Bosnia and Herzegovina and Croatia. We expect that the results of the research conducted under this project will enhance our understanding of sexting and its mechanisms among culturally diverse sample of adolescents and youth adult, which we believe will have a meaningful impact on public policy. In addition to scientific publications and dissemination, we expect that the results of the project will contribute to the involvement of the members of research group in further scientific cooperation activities.]]></summary_en></project><project>
<id>9939</id><title_hr><![CDATA[Epidemiologija bakterije Campylobacter jejuni u galebova klaukavaca, Larus michahellis u Hrvatskoj, kroz koncept „Jedno zdravlje“]]></title_hr><title_en><![CDATA[Epidemiology of Campylobacter jejuni in Yellow-legged Gulls, Larus michahellis in Croatia following “One Health” concept]]></title_en><user_id>1110</user_id><user_firstLast_name>Luka Jurinović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2020-02</proposal_call><code>UIP-2020-02-2528</code><acronim><![CDATA[EpiCGulls]]></acronim><duration>22.03.2021 - 21.09.2026</duration><status>U tijeku</status><financ_value>265.432,49 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Veterinarska medicina, </scie_field_hr><scie_field_en>Veterinary medicine, </scie_field_en><institution_hr><![CDATA[Hrvatski veterinarski institut]]></institution_hr><institution_en><![CDATA[Croatian Veterinary Institute]]></institution_en><team_members_id>1147, 25632, 865010, 865416, 6233, 866729, </team_members_id><team_members_names><![CDATA[Sanja Duvnjak, Louie Thomas Taylor, Biljana Ječmenica Ječmenica, Sanjin Hadžalić, Silvija Šoprek, Katarina Horvat, ]]></team_members_names><keywords_hr><![CDATA[Campylobacter, Galebovi, Hrvatska, Jedno zdravlje, WGS, AMR]]></keywords_hr><keywords_en><![CDATA[Campylobacter, Gulls, Croatia, One Health, WGS, AMR]]></keywords_en><summary_hr><![CDATA[Kampilobakterioza je  od 2005. godine najčešće prijavljivani gastrointestinalni patogen u ljudi u Europskoj uniji. Glavni cilj ovog projekta je napraviti sustavnu i sinkroniziranu prostorno-vremensku studiju epidemiologije Campylobacter jejuni. Galebovi su jedna od najčešćih vrsta ptica u ljudskom okruženju, a nedavno su počeli naseljavati gradove i ostvaruju puno više kontakta s ljudima. Tijekom projekta ćemo uhvatiti i uzorkovati vise od 1500 galebova klaukavaca, na kolonijama (kako prirodnim, tako i urbanim na krovovima ljudskih nastambi) i na odlagalištima otpada, i testirati ih na prisutnost bakterije Campylobacter jejuni. Četrdeset odraslih ptica ćemo označiti GPS GSM odašiljačima kako bismo dobili precizne podatke o njihovim kretanjima i korištenju prirodnih i urbanih staništa. Nakon određivanja prevalencije ciljanog patogena, koristit ćemo najodvedenije molekularne metode (WGS i cgMLST) za genotipizaciju izolata. Usporedo ćemo genotipizirati i izolate iz peradi, svinja, goveda i ljudi te pokušati odrediti izvore epidemiologije ovog patogena u Republici Hrvatskoj. Jedan od rezultata projekta bit će i baza od oko 400 genotipiziranih Campylobacter jejuni s područja cijele države. Baza takvih podataka na ovim prostorima ne postoji što se pokazalo kao vrlo ograničavajući čimbenik u epidemiološkom i epizootiološkom praćenju infekcija ovim uzročnikom. Pošto je antimikrobna rezistencija globalni zdravstveni problem, jedan od najvažnijih ciljeva projekta će biti i testiranje antimikrobne rezistencije sojeva i  identificiranje multirezistentnih sojeva bakterija koje nose galebovi .Naš cilj je odrediti prevalenciju ovog patogena kroz godišnji ciklus između različitih populacija i različitih dobnih kategorija galebova klaukavaca, s potpunijim znanjem o njihovim kretanjima i interakciji s ljudskom populacijom te izdvojene sojeve usporediti  i s ostalim izolatima u svrhu rasvjetljavanja putova kretanja zaraze u ekosustavu. ]]></summary_hr><summary_en><![CDATA[Campylobacteriosis has been the most commonly reported gastrointestinal pathogen in humans in the European Union since 2005. The main objective of this project is to make a systematic and synchronized spatio-temporal study of the epidemiology of Campylobacter jejuni. Gulls are one of the most common bird species in the human environment, and they have recently started inhabiting cities and have much more contact with humans. During the project, we will capture and sample more than 1,500 gulls in the colonies (both natural and urban on human habitats) and landfills, and test them for the presence of Campylobacter jejuni. Forty adult birds will be tagged with GPS GSM loggers to provide more accurate information on their movements and use of natural and urban habitats. After determining the prevalence of the target pathogen, we will use the most advanced molecular methods (WGS and cgMLST) to genotype the isolates. We will also genotype the isolates from poultry, pigs, cattle and humans and try to determine the sources of epidemiology of this pathogen in the Republic of Croatia. One of the results of the project will be a database of about 400 genotyped Campylobacter jejuni from across the country. As antimicrobial resistance is a global health problem, one of the most important goals of the project will be to identify potential multidrug resistant strains of gull-borne bacteria, so we will test those isolates for antimicrobial resistance.Our goal is to determine the prevalence of this pathogen throughout an annual cycle between different populations and different age categories of Yellow-legged Gulls and , with a much better knowledge of their movements and interaction with the human population, to shed light on the pathways of infection in the ecosystem by comparison with other isolates.]]></summary_en></project><project>
<id>9940</id><title_hr><![CDATA[Fenotipski odgovor provenijencija obične bukve i hrasta kitnjaka na dugotrajnu sušu u interakciji s različitom koncentracijom fosfora u tlu]]></title_hr><title_en><![CDATA[Phenotypic response of common beech and sessile oak provenances to long-lasting drought in interaction with different phosphorus concentrations in the soil]]></title_en><user_id>11167</user_id><user_firstLast_name>Krunoslav Sever</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2020-02</proposal_call><code>IP-2020-02-5204</code><acronim><![CDATA[PhenoInter]]></acronim><duration>01.01.2021 - 31.12.2024</duration><status>Završio</status><financ_value>89.086,35 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Šumarstvo, Biotehnologija, </scie_field_hr><scie_field_en>Forestry, Biotechnology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet šumarstva i drvne tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Forestry and Wood Technology]]></institution_en><team_members_id>11184, 44, 11214, 11304, 4927, 865175, 865373, 866695, </team_members_id><team_members_names><![CDATA[Željko Škvorc, Saša Bogdan, Ida Katičić Bogdan, Daniel Krstonošić, Tomislav  Karažija, Antonia Vukmirović, Marko Bčurin, Magdalena Brener, ]]></team_members_names><keywords_hr><![CDATA[obična bukva, hrast kitnjak, provenijencija, sušni stres, fosfor]]></keywords_hr><keywords_en><![CDATA[common beech, sessile oak, provenance, drought stress, phosphorus ]]></keywords_en><summary_hr><![CDATA[Pod utjecajem klimatskih promjena na području Europe u posljednje vrijeme dolazi do ometanja uredne ishrane šumskoga drveća s fosforom (P). S druge strane, adekvatna ishranjenost šumskog drveća s P mogla bi ublažiti negativne posljedice sušnoga stresa i podići njegovu toleranciju prema suši. Ta pretpostavka temelji se na fiziološkoj ulozi P koji regulira fotosintezu i glikolizu te kontrolira asimilaciju CO2 i produkciju biomase. Obična bukva i hrast kitnjak diljem Europe tvore mješovite šumske zajednice koje pridolaze na suhim i vlažnim staništima čija se tla nerijetko odlikuju različitom koncentracijom P. Genetska raznolikost hrasta kitnjaka i obične bukve na području jugoistočne Europe (kamo spada i Republika Hrvatska) kao i njihova unutarvrsna adaptivna varijacija u odgovoru na sušni stres do sada je vrlo rijetko istraživana. Uz to, postojanje eventualnih interakcija između različitih genotipova (provenijencija obične bukve i/ili hrasta kitnjaka) izloženih sušnom stresu pri različitim koncentracijama P u tlu još uvijek predstavlja nepoznanicu koja će se pokušati rasvijetliti ovim projektom. Prema tome, primarni ciljevi ovoga projekta su: (1) utvrditi utjecaj povišene koncentracije P u tlu na toleranciju obične bukve i hrasta kitnjaka prema sušnom stresu, (2) utvrditi postojanje lokalne adaptiranosti provenijencija obične bukve i hrasta kitnjaka na sušni stres, kao i genotipskih razlika u toleranciji na sušu pod utjecajem povišene koncentracije P u tlu i (3) utvrditi postojanje tzv. memorijskih efekata (after efekata) nakon pretrpljenog sušnog stresa kod obične bukve i hrasta kitnjaka, odnosno utjecaj povišene koncentracije P u tlu na takve efekte. Važnost ovoga projekta ogleda se u doprinosu njegovih rezultata podržavanju gospodarskih i općekorisnih funkcija šuma što bi se moglo pozitivno odraziti na dobrobit čitavoga društva, gospodarstva i struke.]]></summary_hr><summary_en><![CDATA[Under the influence of climate change in Europe there is an obstruction of proper nutrition of forest trees with phosphorus (P). On the other hand, the adequate nutrition of forest trees with P is the factor that could alleviate the negative consequences of drought stress and impruve their tolerance to drought. This assumption is based on the physiological role of P regulating photosynthesis and glycolysis and controling the CO2 assimilation and biomass production. Common beech and sessile oak create mixed forest communities all over Europe while occupying dry and wet habitats with different P concentraions in the soil. Genetic diversity of common beech and sessile oak in Southeastern Europe (including the Republic of Croatia) as well as their intrinsic adaptive variation in response to drought stress has so far been very rarely investigated. In addition, the existence of possible interactions between different genotypes (provenance of common beech and/or sessile oak) exposed to drought stress at different P concentrations in the soil is still unknown, because it will be attempted to determine by this project. Therefore, the primary objectives of this project are: (1) to determine the influence of increased P concentration in soil on tolerance of common beech and sessile oak to drought stress, (2) to determine if there is a local adaptation of the common beech and sessile oak provenances to drought stress, as well as genotypic differences in drought tolerance under the influence of increased P concentration in the soil, (3) to determine if there are so-called memory effects (after effects) caused by drought stress in common beech and sessile oak, i.e. the influence of increased P concentration in the soil on such effects. One of the most important contributions of this project is to support economic and general benefit forest functions, which will have a positive impact on the whole society. ]]></summary_en></project><project>
<id>9947</id><title_hr><![CDATA[Topografija srednjovjekovne Zagrebačke županije (14.-16. stoljeće)]]></title_hr><title_en><![CDATA[Topography of Medeival Zageb County (14th – 16th century)]]></title_en><user_id>28952</user_id><user_firstLast_name>Hrvoje Kekez</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2020-02</proposal_call><code>IP-2020-02-8706</code><acronim><![CDATA[MEDITOP]]></acronim><duration>01.11.2021 - 30.10.2025</duration><status>Završio</status><financ_value>91.714,12 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Povijest, </scie_field_hr><scie_field_en>History, </scie_field_en><institution_hr><![CDATA[Hrvatsko katoličko sveučilište, Zagreb]]></institution_hr><institution_en><![CDATA[Catholic University of Croatia]]></institution_en><team_members_id>1311, 5332, 19794, 29518, 29659, 865043, </team_members_id><team_members_names><![CDATA[Robert Skenderović, Branimir Brgles, Krešimir Regan, Valentina Janković, Tomislav Matić, Matea Jurić, ]]></team_members_names><keywords_hr><![CDATA[srednji vijek, topografija, toponimija, Zagrebačka županija, kulturni krajobraz]]></keywords_hr><keywords_en><![CDATA[Middle Ages, topography, toponymy, Zagreb County, cultural environment]]></keywords_en><summary_hr><![CDATA[Rabeći suvremene metode i oslanjajući se na recentne istraživačke paradigme, prijedlog istraživanja u svoj najuži fokus postavlja istraživanje topografije srednjovjekovne Zagrebačke županije (od 14. do 16. stoljeća) temeljen na sustavnome radu s vrelima, s naglaskom na specifičnim vrstama vrela i arhivskim fondovima koji su osobito bogati topografsko-toponimijskom građom. Takav pristup obuhvatit će više istraživačkih razina: od temeljne koja podrazumijeva rekonstrukciju temeljnih značajki analiziranoga prostora, do složenijih koje se tiču istraživanja odnosa povijesnih društava i njihovoga okoliša. U prvoj fazi rada istraživački će tim prikupiti i obraditi srednjovjekovne toponimijske potvrde, ne samo iz objavljenih zbirki izvora, već i iz neobjavljenih arhivskih fondova. Podatci iz pisanih i kartografskih vrela biti će digitalizirani i upotpunjeni terenskim istraživanjima. Ograničavajući se na područje povijesne Zagrebačke županije istraživački će se tim moći usmjeriti – uz središta srednjovjekovnih župa, trgovišta i druge centre naseljenosti – na mikroregionalne cjeline, mikrotoponime te granične linije (odnosno pojaseve razgraničenja na različitim razinama, administrativnim, simboličkim, povijesnim itd.). Osim brojnih istraživačkih pitanja povezanih s povijesnim okolišem (utjecaj okoliša na povijesna zbivanja, utjecaj društvenih zajednica na promjenu prostora), među najvažnijim je ciljevima istraživanja artikulacija temeljnih obilježja odnosa čovjeka i prostora u dijakronijskoj perspektivi. Navedeni će ciljevi biti postignuti povezivanjem spoznaja o topografiji i toponimiji dobivenih analizom povijesnih potvrda i rekonstrukcijom vanjskih obilježja analiziranoga prostora. ]]></summary_hr><summary_en><![CDATA[This proposed research project intends to focus on researching the topography of the medieval County of Zagreb (from the 14th to the 16th century), by using modern research methods and relying on recent research paradigms. Its basis would be a consistent study of primary sources, with an emphasis on specific types of sources and archive funds particularly rich in topographically and toponymycally relevant material. Such an approach would demand several levels of research, from the basic level, meaning a reconstruction of fundamental characteristics of the analyzed area, to complex levels dealing with the relations between past societies and their environment. During the first phase of the project, the research team would gather and analyze medieval toponymical data, not only from printed collections of sources, but also from unpublished archive material. By limiting itself to the area of the medieval Zagreb County, the research team would be able to focus not only on medieval parish seats, market towns and other population hubs, but also on micro-regional units, micro-toponymics and border lines (or rather, border belts on various levels – administrative, symbolic, historical etc.). Besides tackling a number of issues regarding environmental history (influence of the environment on historical events, influence of communities on environmental changes), one of the main goals of this project would be to research the articulation of the basic characteristics of the relations between man and space, in a dyachronical perspective. The aforementioned goals would be accomplished by combining the knowledge of topography and toponymy gained by analyzing the sources, and by reconstructing the external characteristic of the studied area. ]]></summary_en></project><project>
<id>9948</id><title_hr><![CDATA[Uloga farmakogenomike u predviđanju nuspojava kardiovaskularnih lijekova]]></title_hr><title_en><![CDATA[Pharmacogenomics in prediction of cardiovascular drugs adverse reaction]]></title_en><user_id>4369</user_id><user_firstLast_name>Tamara Božina</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2020-02</proposal_call><code>UIP-2020-02-8189</code><acronim><![CDATA[PGx-CardioDrug]]></acronim><duration>15.12.2020 - 14.12.2025</duration><status>U tijeku</status><financ_value>172.373,75 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Clinical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>4713, 5021, 13257, 5362, 26833, 865319, 867634, 867637, </team_members_id><team_members_names><![CDATA[Lana Ganoci, Iva Mucalo, Livija Šimičević, Jure Samardžić, Majda Vrkić Kirhmajer, Jozefina Palić, Dunja Leskovar, Ana Marija Slišković, ]]></team_members_names><keywords_hr><![CDATA[farmakogenomika, nuspojave, kardiovaskularne bolesti, smjernice, varijanta gena, personalizirano liječenje]]></keywords_hr><keywords_en><![CDATA[pharmacogenomics, adverse drug reactions, cardiovascular disease, guidelines, gene variant, personalized treatment]]></keywords_en><summary_hr><![CDATA[S razumijevanjem interindividualnih razlika na razini sekvence DNA, unaprijeđena je sposobnost povezivanja učinaka lijeka s varijantama gena (farmakogeni).Posljedice genetičkih varijacija su brojne od neučinkovitosti do ozbiljnih nuspojava lijeka (NL). Varijabilnosti u sustavu ADME gena koji moduliraju apsorpciju, distribuciju, metabolizam i izlučivanje lijeka su značajne. Čimbenik genetičke varijabilnosti može doprinositi s udjelom od 25-40 % u ukupnoj neočekivanoj reakciji na lijek. Stoga je važno za procjenu varijabilnosti farmakoterapije uključiti i druge prvenstveno kliničke i okolišne čimbenike koji uključuju komorbiditete te politerapiju s povećanim rizikom interakcija, a time i štetnih učinaka lijekova. Korelacije uglavnom pojedinačnog gena i lijeka su potvrđene za neke kardiovaskularne (KV) lijekove, međutim značajan je broj onih lijekova za koje još nemamo jednoznačnih farmakogenomskih podataka koji bi mogli biti translatirani u kliničke smjernice. To se prvenstveno odnosi na direktne oralne antikoagulanse, tikagrelor, prasugrel, rosuvastatin, fluvastatin, većinu antihipertenziva i antiaritmika. KV bolesnici su često na politerapiji, uz to stariji bolesnici imaju i druge komorbiditete koji povećavaju rizik interakcija lijekova. Uspostavljanjem multidisciplinarne istraživačke grupe (klinički specijaliste, farmaceut i laboratorijski analitičari), stvara se preduvjet za sustavno istraživanje nuspojava KV lijekova. Studija slučajeva bolesnika s nuspojavama i kontrolnih ispitanika, uključit će 800 ispitanika na politerapiji KV lijekovima prvenstveno onih za koje još nema jednoznačnih farmakogenetičkih podataka. U multivarijatnoj statističkoj analizi procjene rizika nastanka nuspojava uz genetičke varijable bit će uključeni i drugi negenetički, klinički čimbenici. Rezultati projekta će rezultirati novim saznanjima o višestrukim interakcijama kardivaskularnih lijekova i povezanih gena s visokim potencijalom primjenjivosti u kliničkoj praksi.]]></summary_hr><summary_en><![CDATA[With the understanding of interindividual differences at the level of DNA sequence, the ability to relate drug effects to gene variants (pharmacogenes) has been enhanced. The consequences of genetic variations range from inefficiencies to adverse drug reactions (ADRs). The variations in the ADME genes that modulate drug absorption, distribution, metabolism and excretion are significant. The genetic variability may contribute with a proportion of 25-40% in the overall unexpected drug response. Therefore, it is important in assessing the variability of pharmacotherapy include other primarily clinical and environmental factors like comorbidities and polytherapy with an increased risk of interactions and therefore ADRs. Correlations of single gene and drug have been confirmed for some cardiovascular (CV) drugs, however, there are a significant number of those drugs for which we do not have unambiguous pharmacogenomics data that could be translated into clinical guidelines. This applies primarily to direct oral anticoagulants, ticagrelor, prasugrel, rosuvastatin, fluvastatin, most antihypertensives and antiarrhythmic agents. CV patients are often on polytherapy, and older patients also have other comorbidities that increase the risk of drug interactions. Establishing a multidisciplinary research group (clinical specialists, pharmacist and laboratory analysts) creates the precondition for systematic investigation of the ADRs of CV drugs. The case study of patients with adverse reactions and control subjects will include 800 subjects on CV polytherapy with medicines primarily those for which reliable pharmacogenetic data are missing. In a multivariate statistical analysis of the assessment of ADRs, besides gene variants, other non-genetic, clinical factors will be included. The results of the project will result in new insights into the multiple interactions of cardiovascular drugs and related genes with high applicability potential in clinical practice.]]></summary_en></project><project>
<id>9956</id><title_hr><![CDATA[Regulacija endocitoze na velikoj skali pomoću IQGAP proteinima srodnih proteina IqgC i IqgD]]></title_hr><title_en><![CDATA[Regulation of large-scale endocytosis by IQGAP-related proteins IqgC and IqgD]]></title_en><user_id>12535</user_id><user_firstLast_name>Vedrana Filić Mileta</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2020-02</proposal_call><code>IP-2020-02-1572</code><acronim><![CDATA[RegEndIqCD]]></acronim><duration>15.02.2021 - 14.07.2025</duration><status>Završio</status><financ_value>130.731,97 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>7715, 29200, 12533, 25284, 865233, 865524, </team_members_id><team_members_names><![CDATA[Igor Weber, Huaqing  Cai, Marko Šoštar, Lucija Mijanović, Anja Privara, Darija Putar, ]]></team_members_names><keywords_hr><![CDATA[endocitoza na velikoj skali, IQGAP, RasGAP, Ras GTPaze, aktinski citoskelet, Dictyostelium]]></keywords_hr><keywords_en><![CDATA[large-scale endocytosis, IQGAP, RasGAP, Ras GTPases, actin cytoskeleton, Dictyostelium]]></keywords_en><summary_hr><![CDATA[Endocitoza na velikoj skali je endocitoza velikih volumena koja je neovisna o klatrinu, a vođena je aktinskim citoskeletom. Pojam skupno opisuje unos čestica ili fagocitozu i neselektivan unos velikih količina tekućine ili makropinocitozu. Za jednostanične organizme poput amebe Dictyostelium endocitoza na velikoj skali je ekskluzivan način hranjenja, dok je za stanice metazoa samo jedan od nekoliko, iako ne preferiran način unosa hranjivih tvari. Međutim, stanice sisavaca koriste obje vrste endocitoze na velikoj skali za druge fiziološke funkcije. Najbolji primjer su stanice imunološkog sustava koje koriste i fagocitozu i makropinocitozu za uklanjanje apoptotskih stanica i patogena iz tkiva te za pretraživanje izvanstanične tekućine na prisutnost stranih antigena. Endocitoza na velikoj skali povezana je i s nekim patološkim stanjima poput neurodegenerativnih bolesti, ateroskleroze i raka. Cilj ovog projekta je istražiti ulogu dva IQGAP proteinima srodna proteina, IqgC i IqgD, u regulaciji endocitoze na velikoj skali u organizmu Dictyostelium, koji je postao vodeći model u istraživanju makropinocitoze. Naši prethodni rezultati identificirali su IqgC kao negativni regulator Ras aktivnosti tijekom endocitoze na velikoj skali u fazama stvaranja endosoma. Međutim, daljnji preliminarni podaci sugeriraju da IqgC ima dodatne uloge tijekom sazrijevanja endosoma, vjerojatno putem drugih interaktora. Naš cilj je razjasniti ove funkcije testiranjem njegovih interakcija s fosfolipidima i određivanjem mehanizma njegove regrutacije na membranu. Drugi dio projekta usredotočit će se na biološke uloge IqgD. Naši preliminarni podaci pokazuju kortikalnu lokalizaciju IqgD, uključujući makropinosome. Ova lokalizacija, uz prisustvo domene koja veže aktin, snažno sugerira mehanističku ulogu IqgD u makropinocitozi putem regulacije aktinskog citoskeleta. Cilj je identificirati izravne interaktore IqgD i odrediti na koji način on regulira endocitozu na velikoj skali.]]></summary_hr><summary_en><![CDATA[Large-scale endocytosis is clathrin-independent, actin-driven bulk endocytosis. The term collectively describes particle uptake or phagocytosis and nonselective bulk uptake of fluid or macropinocytosis. For unicellular organisms like amoeba Dictyostelium, large-scale endocytosis is an exclusive way of feeding, while for metazoan cells it is one of several, not preferred, pathways of nutrient uptake. However, mammalian cells use both types of large-scale endocytosis for other physiological functions, besides feeding. The best example are cells of immune system that use both phagocytosis and macropinocytosis for removal of apoptotic cells and pathogens from tissues and to scan extracellular fluids for the presence of foreign antigens. Large-scale endocytosis is also linked to several pathological conditions like neurodegenerative diseases, atherosclerosis and cancer. This project aims to investigate the role of two IQGAP-related proteins, IqgC and IqgD, in regulation of large-scale endocytosis in Dictyostelium, which has become the leading model in macropinocytosis research. Our previous results identified IqgC as a negative regulator of Ras activity during large-scale endocytosis in stages of endosome formation. However, further preliminary data suggest that IqgC plays additional roles during endosome maturation, probably via interactors other than Ras. We aim to elucidate these functions by tackling its phospholipid interactions and by determining requirements for its membrane recruitment. The second part of the project will focus on biological roles of IqgD. Our preliminary data show cortical localization of IqgD, including macropinosomes. This localization, along with the presence of an actin-binding domain in its sequence, strongly suggests mechanistic role for IqgD in macropinocytosis via regulation of actin cytoskeleton. Our goal is to identify direct binding partners of IqgD and determine how it regulates large-scale endocytosis.]]></summary_en></project><project>
<id>9959</id><title_hr><![CDATA[Cementni kompoziti ojačani otpadnim vlaknima]]></title_hr><title_en><![CDATA[Cementitious Composites Reinforced with Waste Fibres]]></title_en><user_id>5060</user_id><user_firstLast_name>Ana Baričević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2020-02</proposal_call><code>UIP-2020-02-5242</code><acronim><![CDATA[ReWire]]></acronim><duration>08.02.2021 - 07.02.2026</duration><status>U tijeku</status><financ_value>174.003,85 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Građevinarstvo, Temeljne tehničke znanosti, </scie_field_hr><scie_field_en>Civil engineering, Basic engineering sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Građevinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Civil Engineering]]></institution_en><team_members_id>3218, 29584, 864829, 865113, </team_members_id><team_members_names><![CDATA[Marija Jelčić Rukavina, Marina Frančić Smrkić, Katarina Didulica, Branka Mrduljaš, ]]></team_members_names><keywords_hr><![CDATA[otpadna vlakna, hibridni mikroarmirani kompoziti, raspodjela vlakana, sučeljak, trajnost, LCA]]></keywords_hr><keywords_en><![CDATA[waste fibres, hybrid fiber reinforced composites, distribution of fibers, ITZ,  durability, LCA]]></keywords_en><summary_hr><![CDATA[Građevinska industrija je najveći svjetski potrošač prirodnih resursa i odgovorna je za 25-40% globalne emisije ugljičnog dioksida. Stoga su potrebni zajednički napori za promicanje prelaska na gospodarstvo s niskim ekološkim otiskom, koje je klimatsko neutralno, a resursi učinkoviti i kružni. ReWire projekt će doprinijeti prijeko potrebnoj promjeni paradigme u razvoju inženjerskih rješenja razvojem učinkovitih cementnih materijala ojačanih lokalno dostupnim otpadnim vlaknima, uz razumijevanje njihovog dugoročnog utjecaja na okoliš i cjeloživotne troškove građevine. Osim osnivanja autonomne istraživačke skupine koja je nužna za konkurentno sudjelovanje Hrvatske u ovom istraživačkom području, kroz ReWire projekt će se unaprijedit tehnologije primjene visokovrijednih otpadnih vlakana i razviti znanstveni okvir za njihovu uporabu u građevinskom sektoru. Projektom se analizira primjena recikliranih polimernih vlakana iz otpadnih guma te ugljičnih, staklenih i bazaltnih otpadnih vlakana iz proizvodnje visokovrijednih tkanina za građevinarstvo, a sve za ojačanje cementnih kompozita. Ciljevi ReWire projekta su: a) osnivanje istraživačke skupine kao centra znanja za istraživanje, razumijevanje i modeliranje cementnih kompozita ojačanih otpadnim vlaknima, b) povezivanje znanstvenih organizacija, istraživača i opreme kroz regionalnu mrežu te c) usavršavanje istraživačke skupine u istaknutim međunarodnim centrima u istraživačkom području.]]></summary_hr><summary_en><![CDATA[Construction industry is the world largest consumer of natural materials and is responsible for 25-40% of global carbon emissions. Therefore, concerted effort is required to promote a transition towards a low-carbon economy that is climate neutral, resource-efficient and circular. The ReWire project will contribute to the much-needed paradigm shift in the development of engineering solutions. Development of highly effective cementitious materials reinforced with locally available waste fibres will be done, along with a deep understanding of their long-term environmental impacts and the life-cycle costs. Whilst addressing the need to establish an internationally recognized research group to keep Croatia competitively participating in this new research area, the technologies for waste fibre application will be enhanced. This will reduce the disposal of high value materials and develop the scientific background for their application in construction sector. Use of recycled tire polymer fibres & carbon, glass and basalt waste fibres, from the production of high-performance construction textiles, in fibre reinforced cementitious composites will be analysed. ReWire aims to: a) establish new research group as a centre of knowledge for the research, understanding and modelling of cementitious composites reinforced with waste fibres; b) connect scientific organizations, researchers and equipment through a regional network; and c) train research group by international centres recognized in the research field.]]></summary_en></project><project>
<id>9966</id><title_hr><![CDATA[Stanični sustav Arf GTPaza u patogenezi citomegalovirusne infekcije]]></title_hr><title_en><![CDATA[Role of Arf GTPases in pathogenesis of cytomegalovirus infection]]></title_en><user_id>6891</user_id><user_firstLast_name>Gordana Blagojević Zagorac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2020-02</proposal_call><code>IP-2020-02-1323</code><acronim><![CDATA[Arf & CMV]]></acronim><duration>01.06.2021 - 31.05.2025</duration><status>Završio</status><financ_value>90.118,79 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Medicine]]></institution_en><team_members_id>585, 26551, 26289, 21236, </team_members_id><team_members_names><![CDATA[Tamara Gulić, Valentino Pavišić, Natalia Jug Vučko, Silvija Lukanović Jurić, ]]></team_members_names><keywords_hr><![CDATA[citomegalovirus, Arf GTPaze, endosomalno prometovanje, TGN, GEF proteini, GAP proteini]]></keywords_hr><keywords_en><![CDATA[cytomegaloviruses, Arf GTPases, endosomal transport,   TGN, GEF proteins, GAP proteins ]]></keywords_en><summary_hr><![CDATA[Arf proteini su male GTPaze koje funkcioniraju poput molekulskih sklopki, odnosno stalno kruže između svog inaktivnog (GDP) i aktivnog (GTP) oblika. Njihovu aktivaciju posreduju GEF proteini, a inaktivaciju GAP proteini. U aktivnom obliku Arf proteini se vežu za stanične membrane gdje putem novačenja efektorskih molekula mijenjaju strukturu staničnih organela i dinamiku membrana te na taj način kontroliraju prometovanje molekula unutar sekretornog i endocitoznog puta. Citomegalovirusi (CMVs) već tijekom rane faze CMV infekcije dovode do masivne reorganizacije staničnih odjeljaka što u konačnici rezultira stvaranjem citoplazmatskog odjeljka za sklapanje viriona (cVACa). Iako su Arf proteini identificirani kao važan faktor virulencije mnogih infektivnih patogena, o ulozi Arf proteina u CMV infekciji vrlo se malo zna. Tijekom predloženog istraživanja, Western blotom i PCRom ispitati će se izražaj Arfova i njihovih GEFova i GAPova tijekom CMV infekcije, a kolokalizacijom s markerima staničnih odjeljaka utvrditi njihova unutarstanična lokalizacija. Probir GEFova i GAPova temeljit će se na opisanim interaktomima i PLA metodi. Stupanj aktivacije Arf proteina biti će utvrđen Arf aktivacijskim testom, subcelularnim frakcioniranjem i kolokalizacijom Arf proteina s njihovim efektorima. Genska regija citomegalovirusa koja je odgovorna za remodulaciju Arf sustava biti će identificirana uz pomoć virusnih delecijskih mutanti. Ulazak CMV u stanice, kao i formiranje cVACa pratit će se i u uvjetima utišane funkcije Arf proteina siRNA metodom, u uvjetima ekspresije konstitutivno aktivnih/inaktivnih oblika Arf proteina te u uvjetima narušene funkcije njihovih regulatora putem kemijskih inhibitora. Na taj način će se utvrditi uloga Arf proteina tijekom ulaska CMVa u stanice domaćina i njihova uloga u reprogramiranju staničnih membrana tijekom CMV infekcije. Bolje razumijevanje biologije CMV infekcije doprinijeti će stvaranju platforme za razvoj cjepiva te novih antivirusnih lijekova.]]></summary_hr><summary_en><![CDATA[Arf proteins are small GTPases that cycle between inactive (GDP-bound) and active (GTP-bound) form. The Arf GEFs mediate activation of Arfs while the Arf GAPs cause their inactivation. Active Arf proteins bind to cell membranes and through the recruitment of the effector molecules alter the structure of cellular organelles and the membrane dynamics, and thus control the transport of molecules within the secretory and endocytic pathways. Cytomegaloviruses (CMVs) cause massive reorganization of cellular compartments in the early phase of infection which finally results in the creation of a cytoplasmic virus assembly compartment (cVAC). Although Arf proteins have been identified as important virulence factors of many infective pathogens, the role of Arf proteins in CMV infection is not clarified. In proposed project, expression of Arfs and their GAPs and GEFs will be determined by PCR and Western blot, and colocalization with markers of cellular compartments will be used for characterization of their intracellular localization during CMV infection. Described interactomes and PLA will be used for Arf GAPs and GEFs selection. Level of Arf activation will be determined by the Arf activation assay, subcellular fractionation and the colocalisation of Arf proteins with their effectors. The genetic region of CMV that is responsible for the remodulation of the Arfs will be identified by use of CMV deletion mutants. The CMV entry into the cells together with the cVAC formation will be monitored after depletion of Arfs by siRNA, in conditions of constitutive active/inactive forms of Arfs and in conditions of impaired function of their regulators by chemical inhibitors. With this approach the role of Arf proteins during the CMV entry into cell and their role in reprogramming of the cell membranes during CMV infection will be determined. A better understanding of the biology of CMV infection will allow the creation of a platform for development of vaccines and new antiviral drugs.]]></summary_en></project><project>
<id>9968</id><title_hr><![CDATA[Reorganizacija sučelja između ranih endosoma i endosomalnog reciklirajućeg odjeljka]]></title_hr><title_en><![CDATA[Cytomegalovirus reorganization of the interface between  early endosomes and endosomal recycling compartment]]></title_en><user_id>6883</user_id><user_firstLast_name>Hana  Mahmutefendić Lučin</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2020-02</proposal_call><code>IP-2020-02-2916</code><acronim><![CDATA[CREERC]]></acronim><duration>01.01.2021 - 31.12.2024</duration><status>Završio</status><financ_value>121.043,20 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Medicine]]></institution_en><team_members_id>6604, 6963, 21237, 21238, 26855, 26801, 865202, </team_members_id><team_members_names><![CDATA[Pero Lučin, Ljerka Karleuša, Marina Marcelic, Igor Štimac, Zsolt Ruzsics, Messerle Martin, Barbara Radić, ]]></team_members_names><keywords_hr><![CDATA[citomegalovirus, odjeljak za sklapanje virusnih čestica, rani endosomi, endosomalni reciklirajući odjeljak, ubikvitinilacija]]></keywords_hr><keywords_en><![CDATA[cytomegalovirus, viral assembly compartment, early endosomes, endosomal recycling compartment, ubiquitination]]></keywords_en><summary_hr><![CDATA[Biogeneza cVAC (engl. cytoplasmic virion assembly compartment) predstavlja važan, i još nerazjašnjen problem za razumijevanje biologije herpesvirusa. U ovom projektnom prijedlogu ćemo proučavati najranije faze reorganizacije mambranskih organela koje nazivamo preAC (engl. pre-assembly compartment). Ovaj istraživački projekt predstavlja nastavak i  produbljenje našeg prethodnoga rada i fokusira se na stanične mehanizme koje koristi mišji citomegalovirus (MCMV)  na sučelju između ranih endosoma i endosomalnog reciklirajućeg odjeljaka (EE-ERC), odnosno mjestu za koje pretpostavljamo da predstavlja inicijacijski korak cVAC biogeneze. U tu svrhu, MCMV može ciljati (1) domaćinske efektore koji reguliraju procese sortiranja i recikliranja na EE-ERC sučelju, (2) Rab10 i njegove partnere, regulatorne proteine koji kontroliraju EE-ERC prometovanje, i (3) procese ubikvitinilacije koji kontroliraju endosomalno recikliranje, a djeluju prema principu reostata. Ovi potencijalni učinci MCMV djelovanja predstavljaju tri cilja ovog projektnog prijedloga. Kako bismo ih ispunili testirat ćemo skoro 50 staničnih efektora i regulatora na EE-ERC sučelju i njihovu ulogu u nastanku preAC. Stanice će biti inficirane divljim tipom i različitim MCMV rekombinantama, a domaćinski proteini će biti analizirani knock-down (siRNA, inhibitori) i knock-out eksperimentima (CRISPR-Cas9). Nastanak preAC će se pratiti konfokalnom mikroskopijom i rekonstrukcijom mape interakcija na EE-ERC sučelju pomoću BioID testa, imunoprecipitacije, Western blot analize i subcelularnog frakcioniranja. MCMV učinak na kompleksnu mrežu regulatornih proteina i efektora na EE-ERC sučelju će predstavljati značajan znanstveni doprinos ovog projektnog prijedloga. On će razjasniti ne samo najranije stadije patogeneze beta-herpesvirusne infekcije, već i prostorno-vremenske odnose u neinficiranim stanicama, dva nedovoljno razjašnjena fundamentalna biološka procesa.]]></summary_hr><summary_en><![CDATA[The biogenesis of cVAC (cytoplasmic virion assembly compartment) is an outstanding and unresolved issue in the biology of herpesviruses. In this research proposal we will study the earliest stages of host-cell membranous-organelle reorganization which we considers as preAC (pre-assembly compartment). This project represents an extension of our previous work and focuses on cellular mechanisms exploited by murine cytomegalovirus (MCMV) at the interface between early endosomes and endosomal recycling compartment (EE-ERC), since the targeting the EE-ERC interface may be initiation step in the cVAC biogenesis. To achieve this, MCMV may target (1) host-cell effectors that regulates processes of sorting and retrieving at the EE-ERC interface, (2) Rab10 and its interacting partners, regulatory proteins that controls EE-ERC trafficking, and (3) ubiquitination processes that act as a regulatory rheostat mechanism in the endocytic recycling. These potential MCMV targets are aligned as three objectives of the research proposal. To address them, we will test almost 50 host-cell effectors and regulators of the EE-ERC interface and their role in the preAC development. Cells will be infected with wild type and various MCMV recombinants, and host-cell factors analyzed by knock-down (siRNA, inhibitors) and knock-out experiments (CRISPR-Cas9). The preAC development will be monitored by confocal microscopy and reconstruction of the roadmap at the EE-ERC interface by BioID assay, immunoprecipitation, Western blot analysis, and subcellular fractionation. The effect of MCMV on a complex network of host-cell regulatory proteins and effectors at the EE-ERC interface will be a significant research outcome of the project proposal. This outcome may resolve both, the earliest stages in the pathogenesis of beta-herpesvirus infection, and the spatial-temporal physiology of the EE-ERC interface in non-infected cells, the two insufficiently understood fundamental biological processes.]]></summary_en></project><project>
<id>9969</id><title_hr><![CDATA[Utjecaj šećerne bolesti tipa 2 i njezinog liječenja na funkciju limfocita]]></title_hr><title_en><![CDATA[The impact of diabetes mellitus type 2 and its therapy on lymphocyte function]]></title_en><user_id>19638</user_id><user_firstLast_name>Tamara Turk Wensveen</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2020-02</proposal_call><code>IP-2020-02-7928</code><acronim><![CDATA[DIABOLYC]]></acronim><duration>01.04.2021 - 24.08.2025</duration><status>Završio</status><financ_value>184.219,26 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Clinical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Medicine]]></institution_en><team_members_id>29106, 19891, 19051, 29110, 6165, </team_members_id><team_members_names><![CDATA[Dora Gašparini, Dora Fučkar Čupić, Felix Wensveen, Marija Troskot Dijan, Viktor Peršić, ]]></team_members_names><keywords_hr><![CDATA[Deblijne, dijabetes melitus tip 2, limfociti, inzulin, CD8 T stanice, CD4 T stanice, NK stanice, gd T stanice, SGLT-2 inhibitor]]></keywords_hr><keywords_en><![CDATA[Obesity, Diabetes Mellitus Type 2, lymphocytes, insulin, CD8 T cells, CD4 T cells, NK cells, gd T cells, SGLT-2 inhibitor]]></keywords_en><summary_hr><![CDATA[Šećerna bolest tipa 2 (engl. diabetes mellitus type 2, DM2) predstavlja jedan od najvećih javnozdravstvenih izazova svjetskih razmjera. Nedavno izvješće Svjetske Zdravstvene Organizacije procjenjuje da više od 420 milijuna ljudi u svijetu boluje od DM2. DM2 je značajan zdravstveni problem jer je povezan s nizom komorbiditeta, poput kardiovaskularnih bolesti, bubrežne bolesti i retinopatije. Smanjenje funkcije imunoloških stanica podcijenjena je komplikacija DM2-a. Iz tog razloga bolesnici s DM2-om imaju povišen rizik za razvoj komplikacija, koje sežu od smanjenja učinkovitosti cijepljenja sve do povećanja vjerojatnosti za smrtni ishod uslijed gripe. Način na koji DM2 uzrokuje imunološku disfunkciju uglavnom je nepoznat. Dosad nije proučavano utječu li uobičajeni načini liječenja DM2-a i na disfunkciju imunoloških stanica. 	Sveobuhvatni cilj ovog projekta je utvrditi koji načini liječenja dovode do poboljšanja funkcije limfocita u bolesnika s DM2-om. Kako bi ostvarili ovaj cilj, uključit ćemo zdrave dobrovoljce i bolesnike s nekontroliranim DM2-om. Odredit ćemo promjene u fenotipu i funkciji ključnih podskupina limfocita in vitro. Disfunkciju limfocita korelirat ćemo s osnovnim kliničkim parametrima DM2-a, kao što su udio glikiranog HBA1c i razina glukoze u plazmi natašte. Bolesnici će zatim biti podvrgnuti liječenju, a nakon šest mjeseci disfunkcija limfocita bit će ponovno analizirana i korelirana s promjenama u kliničkim parametrima. Analiza cjelokupnog transkriptoma na limfocitima bit će učinjena prije i nakon liječenja radi utvrđivanja glavnih posrednika disfunkcije limfocita. Konačno, izvest ćemo in vivo studiju na miševima s inzulinskom rezistencijom kako bi potvrdili učinke antidijabetičkih lijekova na funkcionalnost imunoloških stanica. 	Ukratko, ovo će istraživanje pružiti uvid u vrijedna nova saznanja o podcijenjenim aspektima šećerne bolesti tipa 2 te omogućiti liječnicima odabir boljih metoda liječenja za svoje bolesnike.]]></summary_hr><summary_en><![CDATA[Diabetes is the silent killer of modern time. A recent report of the WHO estimates that over 420 million people have diabetes mellitus type 2 (DM2) worldwide, of which almost 300.000 in Croatia. DM2 is a major health risk, because it is associated with several potentially life-threatening co-morbidities, such as cardiovascular disease, kidney disease and non-alcoholic fatty liver disease. An underappreciated complication of DM2 is reduced immune cell function. As a result, patients with DM2 are at increased risk for immune-associated complications ranging from reduced vaccination efficiency to cancer and increased mortality following influenza infection. Surprisingly, very little is known about which cells of the immune system are affected by DM2 and whether current treatments alleviate DM2-induced immune dysfunction.	The overall goal of this project is to determine the specific impact of DM2 on immune cell function and whether its negative effects are reversible with anti-diabetic treatment. To accomplish this goal, we will recruit healthy volunteers and patients with uncontrolled DM2 and isolate blood leukocytes. Using phenotypic analysis and functional assays in vitro, we will investigate which immune cells are most affected by DM2 and for what parameters. Lymphocyte dysfunctions will be correlated with key disease parameters of DM2. Blood leukocytes will be analyzed again 6 and 12 months after start of anti-diabetic treatment in patients that reach HbA1c target values. Finally, we will perform whole transcriptome analysis on cells most affected by DM2 before and after treatment, to elucidate key molecular mediators of pathological effects. 	In summary, this study will provide valuable new insights in an underappreciated aspect of diabetes mellitus type 2. More importantly, it will allow clinicians to include the immunological risk profile of patients as an additional parameter when considering their best treatment options. ]]></summary_en></project><project>
<id>9970</id><title_hr><![CDATA[Matrični algoritmi u nekomutativnim asocijativnim algebrama]]></title_hr><title_en><![CDATA[Matrix algorithms in non-commutative associative algebras]]></title_en><user_id>4113</user_id><user_firstLast_name>Ivan Slapničar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2020-02</proposal_call><code>IP-2020-02-2240</code><acronim><![CDATA[MANAA]]></acronim><duration>01.01.2021 - 31.12.2024</duration><status>Završio</status><financ_value>87.597,05 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, Interdisciplinarne prirodne znanosti, </scie_field_hr><scie_field_en>Mathematics, Interdisciplinary natural sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Fakultet elektrotehnike, strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Electrical Engineering, Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>26259, 4088, 8764, 865438, </team_members_id><team_members_names><![CDATA[Anita Carević, Nevena Jakovčević Stor, Vjeran Hari, Thaniporn Chaysri, ]]></team_members_names><keywords_hr><![CDATA[sustavi linearnih jednadžbi, QR rastav, najmanji kvadrati, rastav svojstvenih vrijednosti, rastav singularnih vrijednosti, kvaternioni, tenzori   ]]></keywords_hr><keywords_en><![CDATA[systems of linear equations, QR factorization, least squares, eigenvalue decomposition, singular value decompositiion, quaternions, tensors]]></keywords_en><summary_hr><![CDATA[Standardni koncepti linearne algebre (sustavi linearnih jednadžbi, QR rastav, najmanji kvadrati, rastav svojstvenih vrijednosti, rastav singularnih vrijednosti, itd.) se mogu prirodno proširiti na matrice čiji elementi dolaze iz asocijativnih nekomutativnih algebri. Primjeri uključuju matrice kvaterniona, matrice čiji su elementi opet kvadratne matrice ili čak multi-dimenzionalne rešetke kao tenzori. Analizirat ćemo definicije koje vrijede u ovom općenitijem slučaju, te analizirati postojeće i predložiti nove zanimljive algoritme. Ključni sastojak mnogih algoritama je odgovarajuća Givensova rotacija, koja se lako definira za kvaternione i blok matrice.  Dok su mnogi temeljni algoritmi jednostavna poopćenja standardnih algoritama, finije detalje modernih postojećih algoritama za realne ili kompleksne matrice je teško implementirati u slučaju nekomutativnosti. Istražit ćemo probleme i predložiti moguća rješenja za efikasne algoritme u ovom složenom okruženju. Novi algoritmi će se razviti koristeći &#39;&#39;multiple dispatch&#39;&#39; koncept modernog programskog jezika Julia. Analizirat će se i primjene novih algoritama na obradu slike, posebno ultrazvučne tomografije,  koristeći kvaternione ili tenzore. ]]></summary_hr><summary_en><![CDATA[Standard linear algebra concepts (linear equation, inverses, QR factorization, least squares, eigenvalue decomposition, singular value decomposition, etc.) naturally extended to matrices with elements from associative non-commutative algebra. Examples include matrices of quaternions, matrices whose elements are again square matrices or even multi-dimensional arrays like tensors. We analyze definitions which hold in this more general setting and analyze existing and provide many new interesting algorithms. An essential ingredient of many algorithms is a corresponding Givens rotation, which is easily defined for quaternions or block matrices. While many basic algorithms are simple generalizations of their standard counterparts, finer details of modern algorithms over real or complex field are difficult to implement in the case of  non-commutativity. We will investigate problems and find possible resolutions for efficient algorithms in this more complex setting. New algorithms will be derived using multiple dispatch concept of the modern Julia programming language. Applications of new algorithms to image processing, in particular ultrasound tomography, using quaternions or tensors will also be analyzed.]]></summary_en></project><project>
<id>9971</id><title_hr><![CDATA[Pamćenje (o) književnosti u svakodnevici]]></title_hr><title_en><![CDATA[Remembering Literature in Everyday Life]]></title_en><user_id>25720</user_id><user_firstLast_name>Lovro Škopljanac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2020-02</proposal_call><code>UIP-2020-02-2430</code><acronim><![CDATA[PoKUS]]></acronim><duration>01.03.2021 - 28.02.2026</duration><status>U tijeku</status><financ_value>188.864,56 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filologija, Interdisciplinarne humanističke znanosti, </scie_field_hr><scie_field_en>Philology, Interdisciplinary humanities, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>865296, 866667, </team_members_id><team_members_names><![CDATA[Luka Ostojić, Velna Rončević, ]]></team_members_names><keywords_hr><![CDATA[književna recepcija, studije pamćenja, empirijsko proučavanje književnosti, neprofesionalni čitatelji, komparativna književnost]]></keywords_hr><keywords_en><![CDATA[reception theory, memory studies, empirical study of literature, non-professional readers, comparative literature]]></keywords_en><summary_hr><![CDATA[Projekt &#39;&#39;Pamćenje (o) književnosti u svakodnevici&#39;&#39; odvijat će se u smjeru obuhvatnog utvrđivanja činjenica o pamćenju književnosti u hrvatskoj svakodnevici pomoću polustrukturiranih intervjua s velikim brojem sudionika (tisuću ispitanika). Predloženi je projekt u kontekstu pročavanja književnosti metodološki i rezultatski vrlo inventivan, ponajviše zbog toga što nadređenom predmetu proučavanja – književnosti – pristupa preko neprofesionalnih stvarnih čitatelja, a ne preko profesionalnih glasova autoriteta. Predloženi projekt prema tome namjerava uz pomoć glasova hrvatskih čitatelja početi popunjavati veliku lakunu na području književne recepcije koja zahvaća premoćnu većinu od preko 99% neprofesionalnih čitatelja, o kojima znamo relativno malo. Budući da je, s iznimkom radova voditelja istraživanja, u domaćem znanstvenom prostoru ovakav tip istraživačke tematike i metodologije gotovo nepoznat, projekt PoKUS svakako predstavlja novinu. Ipak, sam projekt se sasvim dobro uklapa u širi međunarodni trend pokušaja stvaranja sinergije humanističkih, društvenih i prirodnih znanosti, kao i sveopći humanistički interes za proučavanje pamćenja i sjećanja koji neprekidno raste kroz protekla dva do tri desetljeća. Projekt ima punu potporu ustanove na kojoj će se izvoditi, Filozofskoga fakulteta Sveučilišta u Zagrebu, koja nudi sve potrebne resurse da se istraživanje provede u svakodnevnom čitateljskom okruženju (najčešće narodne knjižnice) četiri regionalna urbana centra u Hrvatskoj (Zagreb, Split, Rijeka i Osijek). Time će se osigurati ispunjenje ključnoga cilja da nova istraživačka grupa provede istraživanje međunarodno i (pogotovo) nacionalno relevantne tematike, koja se tiče gotovo svih odraslih stanovnika RH.]]></summary_hr><summary_en><![CDATA[The project &#39;&#39;Remembering Literature in Everyday Life&#39;&#39; shall be conducted with the aim of comprehensively identifying facts about the memory of literature in Croatian everyday life through semi-structured interviews with a large number of participants (one thousand respondents). The proposed project is methodologically and results-wise highly inventive in the context of researching literature, mainly because it approaches its overarching subject - literature - through non-professional real readers, and not through professional voices of authority. The proposed project, therefore, intends to utilize the voices of Croatian readers to begin filling the great lacuna in the area of reception theory which affects the vast majority of over 99% of non-professional readers, of whom we know relatively little. Since this type of research topic and methodology is almost unknown in the domestic research space (with the exception of PI&#39;s own work), the project Remembering Literature in Everyday Life is certainly a novelty. However, the project does fit in well with the broader international trend of trying to create synergies in the humanities, social and natural sciences, as well as a universal humanistic interest in the study of memory and remembering that has grown steadily over the past two to three decades. The project has the full backing of the institution at which it will be organized (Faculty of Humanities and Social Sciences in Zagreb, University of Zagreb), which offers all the resources needed to conduct the research in the everyday reading environments (usually public libraries) of four regional urban centers in Croatia (Zagreb, Split, Rijeka and Osijek). Such backing ensures the fulfillment of the key objective of the new research group, which is to carry out research on an internationally and (especially) nationally relevant topic, one which concerns almost all adult residents of the Republic of Croatia.]]></summary_en></project><project>
<id>9972</id><title_hr><![CDATA[Skalabilni algoritmi visokih performansi za buduće heterogene distribuirane računalne sustave]]></title_hr><title_en><![CDATA[Scalable high-performance algorithms for future heterogeneous distributed computer systems]]></title_en><user_id>19686</user_id><user_firstLast_name>Davor Davidović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2020-02</proposal_call><code>UIP-2020-02-4559</code><acronim><![CDATA[HybridScale]]></acronim><duration>18.01.2021 - 17.01.2026</duration><status>U tijeku</status><financ_value>209.479,06 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>864965, 865048, 869874, </team_members_id><team_members_names><![CDATA[Nenad Mijić, Abhiram Kaushik Badrinarayanan, Nikola Sunara, ]]></team_members_names><keywords_hr><![CDATA[računarstvo visokih performansi, skalabilni algoritmi, paralelno računarstvo, GPU programiranje, heterogeno računarstvo, optimizacija]]></keywords_hr><keywords_en><![CDATA[high-performance computing, scalable algorithms, parallel computing, GPU programming, heterogeneous computing, optimisation]]></keywords_en><summary_hr><![CDATA[Heterogeni i distribuirani računalni sustavi danas se sve češće koriste kako bi se ubrzalo rješavanje najzahtjevnijih računalnih problema te omogućilo rješavanje do sada nerješivih problema. Današnji trend pokazuje da je od 500 najjačih računala na svijetu njih čak 133 heterogeno, tj. uz klasične procesore (CPU) opremljeni su i računalnim akceleratorima, najčešće grafičkim procesorima opće namjene (GPU). Također, predviđa se da će buduća exascale računala, računala koja će moći izvršavati više od 10^18 računskih operacija u sekundi, biti temeljena na računalnim akceleratorima. Zbog svoje heterogenosti, razvoj efikasnih i skalabilnih algoritama i aplikacija koje postižu vrlo visoke performanse na takvim sustavima je od presudne važnosti za daljnji razvoj znanosti. Cilj ovog projekta je razviti nove metode te unaprijediti postojeće algoritme numeričke linearne algebre za izvršavanje na velikim distribuiranim heterogenim računalnim sustavima uz postizanje vrlo visokih performansi. Glavni pravci istraživanja su povećati skalabilnost algoritama (s obzirom na veličinu problema i količinu računalnih resursa), smanjiti komunikaciju između pojedinih procesnih jedinica te efikasno iskoristiti kompleksnu memorijsku hijerarhiju heterogenih sustava. Nadalje, istražit će se modeli optimizacije parametara računalnih programa, s obzirom na arhitekturu pojedinog računalnog sustava, u svrhu skraćivanja vremena izvršavanja. Konačno, rezultati istraživanja primijenit će se za rješavanje velikih stvarnih računalnih problema iz drugih područja znanosti kao što su računalna kemija, fizika materijala i molekularna medicina, te tako unaprijediti i ubrzati njihov znanstveni rad. Projekt će pridonijeti razvoju tehnika i metoda za efikasniju paralelizaciju i optimizaciju algoritama za buduće heterogene i distribuirane računalne sustave, te će osnažiti istraživanja iz područja računarstva visokih performansi na Institutu Ruđer Bošković i u Republici Hrvatskoj.]]></summary_hr><summary_en><![CDATA[Heterogeneous and distributed systems are nowadays increasingly being used to speed up the solution of the complex computational problems and to solve, so far, unsolvable ones. Today&#39;s trend shows that from the top 500 most powerful supercomputers in the world, 133 are already heterogeneous, that is, along with the traditional processors (CPUs) they are also equipped with accelerators, mostly graphical processing units (GPUs). It is expected that the future exascale computers, i.e. computers capable of performing more than 10^18 operations per second, will be based on the accelerators. Because of their high heterogeneity, the development of efficient and scalable algorithms and applications, achieving high utilization of such systems, is of the uttermost importance. The goal of this project is to develop new methods and to improve the existing algorithms of numerical linear algebra that will be capable of exploiting large heterogeneous systems while attaining very high performance. The main lines of the research are to increase the scalability of the algorithms (increased problem size and the number of computational resources), to reduce the communication overhead, and to exploit the complex memory hierarchies of the heterogeneous systems. Furthermore, new models for optimizing the parameters of algorithms will be explored concerning the architecture of the underlying computer system, to reduce the total execution time. Finally, the obtained research results will be applied in solving large, real-world computational problems arising in other fields of science, such as computational chemistry, material physics, and molecular medicine, and thus improve and accelerate their future research. The project will contribute to efficient parallelization and optimization of the algorithms for future heterogeneous and distributed systems, and will strengthen the research in the field of high-performance computing at the Ruder Boskovic Institute and the Republic of Croatia.]]></summary_en></project><project>
<id>9984</id><title_hr><![CDATA[Računalni modeli za predviđanje i analizu ličnosti na temelju teksta]]></title_hr><title_en><![CDATA[Computational Models for Text-Based Personality Prediction and Analysis]]></title_en><user_id>6211</user_id><user_firstLast_name>Jan Šnajder</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2020-02</proposal_call><code>IP-2020-02-8671</code><acronim><![CDATA[psy.txt]]></acronim><duration>01.01.2021 - 31.05.2025</duration><status>Završio</status><financ_value>187.404,61 eur</financ_value><scie_area_hr>Tehničke znanosti, Društvene znanosti, </scie_area_hr><scie_area_en>Technological sciences, Social sciences, </scie_area_en><scie_field_hr>Računarstvo, Sociologija, Psihologija, Interdisciplinarne tehničke znanosti, Interdisciplinarne društvene znanosti, </scie_field_hr><scie_field_en>Computer sciences, Sociology, Psychology, Interdisciplinary technological sciences, Interdisciplinary social sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>29510, 29511, 29531, 29568, 29573, 23215, 3634, 7390, 24278, 865180, 865181, 865182, 866844, </team_members_id><team_members_names><![CDATA[Matej  Gjurković,  Mihaela  Bošnjak, Iva Vukojević, Tena Vukasović Hlupić, Martina Pocrnić, Denis Bratko, Ana Butković, Mladen Karan, Irina Masnikosa, Sara Bakic Bakic, Ivan Crnomarković, Josip Jukić, Nina Drobac, ]]></team_members_names><keywords_hr><![CDATA[Obrada prirodnog jezika, strojno učenje, psihologija ličnosti, analiza teksta, jezik na internetu]]></keywords_hr><keywords_en><![CDATA[Natural language processing, machine learning, personality psychology, text analysis, online talk]]></keywords_en><summary_hr><![CDATA[Ljudi se razlikuju u obrascima razmišljanja, osjećanja i ponašanja, što utječe na njihovu interakciju i prilagođavanje intrapsihičkom, fizičkom i društvenom okruženju. Pojedinačne i stabilne razlike proučava  područje psihologije ličnosti. Mnoge razlike u ličnosti očituju se u jeziku i u načinu na koji se jezik koristi u društvenim interakcijama. To jezične podatke čini vrijednim izvorom podataka za istraživanje ličnosti, pogotovo u današnje vrijeme društvenih medija i velikih podataka, gdje na društvenim platformama nastaju ogromne količine teksta. Velike količine teksta, međutim, iziskuju računalni pristup analizi podataka temeljenoj na metodama obrade prirodnog jezika (NLP) i strojnom učenju. Tema ovog projekta jesu računalni modeli za analizu i predviđanje ličnosti iz teksta. Premda NLP i psihologija ličnosti imaju velik sinergijski potencijal, ova dva polja imaju različite ciljeve i vrijednosti, stoga su do sada u velikoj mjeri odvojena jedna od drugog. Ovaj se jaz može pripisati nedostatku odgovarajućih skupova podataka, interpretabilnih NLP modela koji modeliraju jezične pojave na razini diskursa te interdisciplinarnih vještina među istraživačima. Cilj ovoga projekta jest smanjiti taj jaz i postaviti osnove za istinski interdisciplinarno istraživanje u analizi ličnosti na temelju teksta. Projekt okuplja interdisciplinarni tim računalnih znanstvenika i psihologa ličnosti, s ciljem (1) izgradnje novih skupova podataka internetskog teksta i interakcije pogodnih za razvoj NLP modela i analizu ličnosti na temelju teksta, (2) razvijanja NLP modela za predviđanje i analizu ličnosti koji su inovativni, kreativni i učinkoviti, dok istovremeno osiguravaju valjanost i interpretabilnost te (3) provođenja niza konfirmatornih i eksploratornih studija analize podataka za otkrivanje povezanosti osobina ličnosti i jezičnih varijabli razgovora na internetu.]]></summary_hr><summary_en><![CDATA[People differ in patterns of thinking, feeling, and behaving, which influences how they interact and adapt to the intrapsychic, physical, and social environments. The individual and stable differences are studied by the field of personality psychology. Many differences in personality get manifested in language and in the way language is used in social interactions. This makes language data a valuable source of data for personality research, especially in today’s era of social media and big data, with vast amounts of text generated on social media platforms. The large quantities of text, however, mandate a computational approach to data analysis, using methods from natural language processing (NLP) and machine learning. The topic of this project are computational models for personality analysis and prediction from text. Although NLP and personality psychology have a high potential for synergy, the two fields have different goals and values and thus far remain largely disconnected from each other. The gap can be attributed to the lack of adequate datasets, lack of interpretable NLP models that target discourse-level linguistic phenomena, and lack of interdisciplinary skill sets among the researchers. With this project, we aim to narrow this gap and set the ground for truly interdisciplinary research on text-based personality analysis. The project brings together an interdisciplinary team of computer scientists and personality psychologists, with the objectives to (1) compile novel datasets of online text and interaction suitable for the development of NLP models and text-based personality research, (2) develop NLP models for text-based personality prediction and analysis that are innovative, creative, and effective, but at the same warrant validity and interpretability, and (3) run a number of confirmatory and exploratory data analysis studies to investigate the links between personality traits and linguistic variables of online talk and interaction.]]></summary_en></project><project>
<id>9985</id><title_hr><![CDATA[Ekonomski izazovi tranzicije prema niskougljičnom rastu]]></title_hr><title_en><![CDATA[Economic challenges of the transition to low-carbon growth]]></title_en><user_id>7269</user_id><user_firstLast_name>Đula Borozan</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2020-02</proposal_call><code>IP-2020-02-1018</code><acronim><![CDATA[EINURA]]></acronim><duration>10.02.2021 - 09.02.2025</duration><status>Završio</status><financ_value>48.737,02 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, </scie_field_hr><scie_field_en>Economy, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Ekonomski fakultet u Osijeku]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Economics]]></institution_en><team_members_id>4247, 211, 4539, 26500, 26496, </team_members_id><team_members_names><![CDATA[Sanja Pfeifer, Nela Vlahinić Lenz, Dubravka Pekanov Starčević, Sofija Turjak, Ana Zrnić, ]]></team_members_names><keywords_hr><![CDATA[niskougljični rast, staklenički plinovi, tržište ugljika, tranzicija, energija, inovacije, održivo poduzetništvo, GHG izvješćivanje]]></keywords_hr><keywords_en><![CDATA[low-carbon growth, greenhouse gases, carbon market, energy, innovation, sustainable entrepreneurship, GHR reporting]]></keywords_en><summary_hr><![CDATA[Ekonomski rast je izuzetno važan; međutim, kako bi se adekvatno nosili s nepovoljnim društveno-ekonomskim i okolišnim posljedicama, ekonomski rast mora biti društveno i ekološki osjetljiv te u funkciji tranzicije ka niskougljičnoj ekonomiji. Nedostaje znanja kada je riječ o toj tranziciji i njezinim posljedicama. Stoga je prvi cilj projekta analizirati socioekonomske učinke niskougljične tranzicije na ekonomski rast. Energija je vitalna za egzistenciju i razvoj moderne ekonomije; međutim, njezina proizvodnja i potrošnja generiraju negativne emisije stakleničkih plinova. Stoga je drugi cilj istražiti ulogu energije (obnovljive i neobnovljive) i energetske industrije u tranziciji prema niskougljičnom rastu. Kako bi bili ublaženi negativni učinci ekonomskog rasta, potrebna su nova znanja, politike, strategije, upravljački i poslovni modeli, kao i promjene u praksama ponašanja. Stoga je treći cilj istražiti važnost inovacija, upravljanja ljudskim resursima i održivog poduzetništva u izgradnji nisko-ugljične ekonomije.Kako bi bili realizirani ciljevi, projekt će biti baziran na kvantitativnim istraživačkim pristupima. Sukladno tome, bit će razvijeni multivarijantni modeli, primijenjene multivarijantne statističke metode te provedene multivarijantne regresije. Projekt će generirati značajne teorijske i metodološke doprinose. Povećat će postojeće znanje o niskougljičnom rastu fokusiranjem na (i) složene interakcije između energije, inovacija, održivog poduzetništva i politika na različitim razinama,  kao i (ii) razvojem konceptualnih modela pogodnih za tranziciju ka niskougljičnoj budućnosti. Očekivani empirijski doprinosi odnosit će se na produbljivanje našeg razumijevanja o ekonomskoj situaciji i trendovima u Europskoj uniji i Hrvatskoj, kao i na formuliranje javno-političkih preporuka usmjerenih poticanju niskougljičnog rasta i ubrzanju tranzicije ka niskougljičnoj ekonomiji.]]></summary_hr><summary_en><![CDATA[Economic growth is extremely important; however, to adequately combat the adverse socio-economic and environmental consequences, it must be socially and environmental sensitive and support the transition to low-carbon economy.  There is a lack of knowledge related to this transition and its consequences. Hence, the first objective of the project is to analyze the socio-economic effects of the low-carbon transition on economic growth. Energy is vital to the existence and development of a modern economy; but, its generation and consumption generate adverse greenhouse gas emissions. Thus, the second objective is to investigate the role of energy (renewable and non-renewable) and the energy industry in the transition to low-carbon growth. To mitigate the adverse effects of economic growth, new knowledge, policies, strategies, governance and business models as well as changes in behavioral practices are needed. Hence, the third objective is to explore the importance of innovation, human resource management and sustainable entrepreneurship in building a low-carbon economy. The project will be based on quantitative research approaches to achieve the objectives. Accordingly, it will develop multivariate models, apply multivariate statistics and perform multivariate regressions. The project will generate significant theoretical and methodological contributions. In general, it will increase the existing knowledge on low-carbon growth through its focus on (i) the complex interactions between energy, innovation, sustainable entrepreneurship and policies at different levels, and (ii) the development of conceptual models suitable for transitioning to a low-carbon future. The expected empirical contributions will refer to deepening our understanding on the economic situation and trends in the European Union and Croatia in particular, as well as formulating policy recommendations aiming at encouraging low-carbon growth and accelerating the transition to low-carbon economy.]]></summary_en></project><project>
<id>9991</id><title_hr><![CDATA[Interakcija dipeptidil peptidaze III s proteinom SH2 domain-containing protein 3C – moguća veza između odgovora na oksidativni stres i stanične migracije ]]></title_hr><title_en><![CDATA[Dipeptidyl peptidase III interaction with SH2 domain-containing protein 3C – possible link between oxidative stress response and cell migration ]]></title_en><user_id>4619</user_id><user_firstLast_name>Mihaela Matovina</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2020-02</proposal_call><code>IP-2020-02-6743</code><acronim><![CDATA[OxMiLink]]></acronim><duration>01.03.2021 - 28.06.2025</duration><status>Završio</status><financ_value>128.873,85 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Interdisciplinarne prirodne znanosti, Kemija, Biologija, </scie_field_hr><scie_field_en>Interdisciplinary natural sciences, Chemistry, Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>2975, 730, 29452, 29571, 865097, 865384, 2974, 866713, </team_members_id><team_members_names><![CDATA[Antonija Tomić, Ana Tomašić Paić, Koraljka Husnjak, Lucija Horvat, Lea Barbarić, Tea Pavkov-Keller, Sanja Tomić, Marina Oskomić, ]]></team_members_names><keywords_hr><![CDATA[DPP III, SH2D3C, protein-protein interakcije, Nrf2/KEAP1 signalni put, oksidativni stres, migracija stanica]]></keywords_hr><keywords_en><![CDATA[DPP III, SH2D3C, protein-protein interactions, Nrf2/KEAP1 signaling pathway, oxidative stress, cell migration]]></keywords_en><summary_hr><![CDATA[Dipeptidil peptidaza III (DPP III) je cink-ovisna metalopeptidaza koja uzastopno odcjepljuje dipeptide s amino-kraja 3 do 10 aminokiselina dugih peptida te je široko rasprostranjena u organizmima od bakterija do ljudi. Smatra se da ima ulogu u završnim stadijima proteinskog metabolizma u stanici te u regulaciji krvnog tlaka i boli.  DPP III je također uključena u regulaciju Nrf2/KEAP1 signalnog puta kroz kompetitivno vezanje na protein KEAP1 koje dovodi do oslobađanja transkripcijskog faktora Nrf2 i aktivacije odgovora na oksidativni stres. U potrazi za drugim proteinskim interaktorima DPP III, pomoću SILAC-MS metode, identificiran je protein SH2 domain-containing protein 3C (SH2D3C) kao potencijalni interaktor. Interakcija je potvrđena na prekomjerno eksprimiranim proteinima korištenjem nekoliko biokemijskih metoda. SH2D3C je jedan od tri člana proteinske NSP obitelji koji sadrže domenu SH2, RasGEF sličnu domenu te regiju bogatu prolinima i serinima između tih dviju domena. SH2D3C i ostala dva člana porodice (SH2D3A and BCAR3) djeluju kao adaptorski i konstrukcijski proteini koji kontroliraju migraciju stanica integriranjem prijenosa signala preko faktora rasta i integrina, ali precizni način njihovog djelovanja još uvijek je nepoznat. U predloženom istraživanju planiramo potvrditi interakciju na endogenim proteinima, utjecaj svakog od proteina na stanične procese u kojima sudjeluju prekomjernom ekspresijom proteina te izbacivanjem (engl. knock out) gena, odrediti afinitet vezanja pomoću biofizičkih metoda te predvidjeti mjesta vezanja molekulskim modeliranjem. Rezultati predloženog istraživanja omogućit će bolje razumijevanje uloge DPP III u signalnim putevima u koje je uključen SH2D3C i obratno. Imajući u vidu da su kontrola migracije stanica i signalni put Nrf2/KEAP1 često narušeni u raku, rezultati predloženog istraživanja mogli bi otvoriti nove mogućnosti za detekciju biomarkera i liječenje raka. ]]></summary_hr><summary_en><![CDATA[Dipeptidyl peptidase III (DPP III) is a zinc metallopeptidase that sequentially cleaves off dipeptides from the amino-termini of 3 to 10 residue long peptides, ubiquitously present in organisms from bacteria to human. It has assumed role in the final stages of protein turnover in the cell, and in the regulation of blood pressure and pain. DPP III is also involved in the regulation of Nrf2/KEAP1 signalling pathway mediated by the competitive binding to KEAP1 protein that leads to the release of Nrf2 transcription factor and the activation of the oxidative stress response. In the search for other interactors of DPP III by SILAC-MS approach, SH2 domain-containing protein 3C (SH2D3C) was identified as a putative interactor. The interaction was confirmed on overexpressed proteins by several biochemical methods. SH2D3C is one of the three members of the NSP family of proteins which contain both SH2 domain, RasGEF-like domain, and a proline/serine rich region in between. SH2D3C and the other two members of the same family (SH2D3A and BCAR3) serve as adaptor or scaffolding proteins that control cell migration by integrating growth factor and integrin signalling, however, the exact mode of their action is still unknown. We propose to confirm the interaction between endogenous DPP III and SH2D3C and investigate the effect of each protein on the function of the other by the overexpression and knock-down of the genes, determine the affinity of the binding by biophysical methods, and use molecular modelling to predict the likely binding sites. The results of the proposed investigations will enable better understanding of the role of DPP III in the signalling pathways related to SH2D3C in human cells and vice versa. Considering that the cell migration control and Nrf2/KEAP1 signalling pathways are frequently dysregulated in cancer, the results of the proposed research might offer new possibilities for cancer biomarker identification and treatment.]]></summary_en></project><project>
<id>9997</id><title_hr><![CDATA[Molekularni mehanizmi imunološkog odgovora i aktivacije inflamasoma u Parkinsonovoj bolesti]]></title_hr><title_en><![CDATA[Molecular mechanisms of immune response and inflammasome activation in Parkinson&#39;s disease]]></title_en><user_id>2684</user_id><user_firstLast_name>Fran Borovečki</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2020-02</proposal_call><code>IP-2020-02-8475</code><acronim><![CDATA[IMMUNE PD]]></acronim><duration>15.01.2021 - 14.05.2025</duration><status>Završio</status><financ_value>179.252,20 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, Clinical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>5330, 19042, 29182, 5749, 5654, 19045, 29596, 29700, 1278, 6937, 5967, 20327, 865171, 12852, </team_members_id><team_members_names><![CDATA[Kristina Gotovac Jerčić, Antonela Blažeković, Tiago Fleming Outeiro, Filip Josip Bingula, Lidija Cvetko Krajinović, Srđana Telarović, Borislav Radić, Miroslav Mayer, Mario Matijašić, Helena Šarac, Alemka Markotić, Gordana Pavliša, Sarah Meglaj, Ervina Bilić, ]]></team_members_names><keywords_hr><![CDATA[genomika, Parkinsonova bolest, alfa sinuklein, NGS, imunološki odgovor, dendritičke stanice, CD4+ T limfociti, inflamasomi]]></keywords_hr><keywords_en><![CDATA[genomics, Parkinson&#39;s disease, alpha synuclein, NGS, immune response, dendritic cells, CD4+ T lymphocytes, inflammasome]]></keywords_en><summary_hr><![CDATA[Parkinsonova bolest (PB) je progresivna neurodegenerativna bolest karakterizirana nakupljanjem proteina i degeneracijom dopaminergičkih neurona. Temeljni mehanizmi koji uzrokuju PB nisu u potpunosti jasni. Pokazano je da trajni upalni odgovor igra važnu ulogu u patogenezi PB rezultirajući gubitkom dopaminergičkih neurona. Do danas je pokazano da je nekoliko tipova imunoloških stanica uključeno u progresiju PB. Dendritičke stanice (DS) su spona između imunološkog odgovora i neurodegenerativnih procesa, a infiltracija T limfocita propagira neurodegeneraciju generiranjem štetnog imunološkog odgovora. Nadalje, pokazana je snažna korelacija između inflamasoma i neurodegeneracije što ukazuje na moguću povezanost autoimunog odgovora s gubitkom neurona. Cilj projekta je definirati i opisati temeljne mehanizme imunološkog odgovora i aktivacije inflamasoma u oboljelih od PB pomoću naprednih genomskih metoda kako bi se rasvijetlili putovi uključeni u regulaciju imunološkog sustava. Osim toga, analizirat ćemo potencijalne proteinske biomarkere iz krvi koji sudjeluju u upalnim putovima i povezati rezultate s analizom genske ekspresije. Otkrivene varijante gena i različiti ekspresijski profili odabranih subpopulacija imunoloških stanica dalje će se karakterizirati pomoću staničnih linija, te na uzorcima humanih mozgova. Konkretno, istražit ćemo imunološki odgovor utišavanjem i pojačanom ekspresijom odabranih gena u DS linijama generiranim od PB pacijenata i zdravih kontrolnih ispitanika. Dodatno, želimo definirati uzročno-posljedičnu vezu između nakupljanja aSyn i imunološkog odgovora utišavanjem istaknutih gena u SH-SY5Y staničnoj liniji i u primarnim kortikalnim neuronima. Konačno, da bismo potvrdili mehanicističke rezultate, posljednji korak bit će provođenje imunohistokemijskih eksperimenata na preparatima humanih mozgova. Rezultati projekta će pomoći u identificiranju novih potencijalnih ciljeva za neuroprotektivno liječenje usmjereno na modulaciju imunološkog odgovora.]]></summary_hr><summary_en><![CDATA[Parkinson&#39;s disease (PD) is a progressive neurodegenerative disease characterized by proteinaceous aggregates and degeneration of dopaminergic neurons. The underlying mechanisms causing PD have not been fully elucidated. Persistent inflammation is a major aggravating factor in PD resulting in the loss of dopaminergic neurons. To date, several immune cell types have been shown to be responsible for driving PD progression. Dendritic cells (DCs) lie at the intersection of the immune response and the neurodegenerative process while T cell infiltration generates a harmful immune response. Additionally, there is a strong correlation between inflammasomes and neurodegeneration indicating a possible association between the autoimmune response and neuronal loss. The aim of the project is to identify and characterize underlying mechanisms of immune response and inflammasome activation in PD patients using genomic analyses in order to decipher the pathways involved in the immune system regulation. Furthermore, we will analyze potential protein biomarkers from blood involved in inflammatory pathways and correlate the results with gene expression analyses. The detected gene variants and differential expression profiles of selected immune cell subpopulations will further be characterized using cell lines, as well as in human brain samples. In particular, we will validate the immune response using the knockdown and overexpression approach in DC lines generated from PD patients and healthy controls. In addition, we aim to define the causal relationship between aSyn accumulation and the immune response by knockdown of identified genes in the SH-SY5Y cell line and primary cortical neurons. Finally, in order to validate our mechanicistic findings, the last step will be to perform immunohistochemistry experiments on human brain sections. The results of the project may help identify novel putative targets for development of neuroprotective treatments by modulating the immune response.]]></summary_en></project><project>
<id>9998</id><title_hr><![CDATA[Numerička procjena rizika od rupture nekomplicirane disekcije aorte tipa B]]></title_hr><title_en><![CDATA[Numerical assessment of an uncomplicated type B aortic dissection rupture risk]]></title_en><user_id>7644</user_id><user_firstLast_name>Željko Tuković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2020-02</proposal_call><code>IP-2020-02-4016</code><acronim><![CDATA[LessPatients]]></acronim><duration>01.03.2021 - 31.07.2025</duration><status>U tijeku</status><financ_value>127.413,90 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, </scie_field_hr><scie_field_en>Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>19003, 1012, 25392, 29583, 29707, 26369, 865138, </team_members_id><team_members_names><![CDATA[Nino Horvat, Lana Virag, Josip Živić, Gabriel Mistelbauer, Tomislav Krpan, Mislav Vrsalović, Anja Horvat, ]]></team_members_names><keywords_hr><![CDATA[torakalna aorta, nekomplicirana disekcija, tromb, ruptura, numerički model, FSG]]></keywords_hr><keywords_en><![CDATA[thoracic aorta, uncomplicated dissection, thrombus, rupture, numerical model, FSG]]></keywords_en><summary_hr><![CDATA[Stvaranje lažnog lumena, koji je od pravog lumena odvojen intimom i dijelom medije jedna je od karakteristika disekcije aorte. One se dijele na tip A (uzlazna aorta) i tip B (koji zahvaća uglavnom silaznu torakalnu aortu). Tip A i komplicirane aortne disekcije tipa B liječe se kirurški. S druge strane pokazalo se da operacija nekompliciranih disekcija tipa B ne poboljšava preživljavanje pacijenata unutar dvije godine nakon operacije te se nekomplicirane disekcije obično samo slikovno prate svakih šest mjeseci. Stoga su numerički modeli i proračuni nekompliciranih disekcija tipa B važni i mogu se koristiti pri procjeni hoće li nekomplicirana disekcija postati komplicirana te se na taj način pomoglo liječnicima pri odluci o daljnjoj terapiji. U okviru ovog projekta pratit će se grupa pacijenata s nekompliciranom disekcijom tipa B. na osnovi podataka od pacijenata te dostupne litarature razvit će se numerički model koji može predvidjeti tijek razvoja disekcije. Takva vrsta rezultata pomoći će liječnicima u odluci da li pristupiti operativnom zahvatu te će na taj način smanjiti broj nepotrebnih zahvata.]]></summary_hr><summary_en><![CDATA[The creation of a false lumen, which is separated from the true lumen by an intimal flap is main characteristic of aortic dissection. Dissections are classified as Type A (starting at the ascending aorta) and Type B (affecting mostly the descending thoracic aorta). Type A and complicated type B aortic dissections are treated surgically, however, it has been shown that surgery of uncomplicated Type B dissections does not improve 2-year survival. Additionally, partial thrombosis of the false lumen, as compared with complete patency or no thrombosis at all, has been showed to be a significant independent predictor of postdischarge mortality in patients with uncomplicated type B aortic dissection. The main goal of the project is to define the patient subpopulation with uncomplicated type B dissection that would have benefit from an early surgical intervention. Based on aquired data from patients and literature numerical model, that could predict development of dissection, will be developed. This would decrease the number of unnecessary surgeries of stable aortic dissections.]]></summary_en></project><project>
<id>10003</id><title_hr><![CDATA[Distribucijska elektroenergetska mreža s velikim udjelom aktivnih kupaca]]></title_hr><title_en><![CDATA[Prosumer-rich distribution power network]]></title_en><user_id>29523</user_id><user_firstLast_name>Goran Knežević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2020-02</proposal_call><code>UIP-2020-02-5796</code><acronim><![CDATA[ProPowerNet]]></acronim><duration>01.01.2021 - 31.12.2025</duration><status>U tijeku</status><financ_value>208.617,03 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera Osijek, Fakultet elektrotehnike, računarstva i informacijskih tehnologija Osijek]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Electrical Engineering, Computer Science and Information Technology Osijek]]></institution_en><team_members_id>23228, 25526, 29538, 29550, 25879, 864846, 864906, 865198, 869696, </team_members_id><team_members_names><![CDATA[Krešimir  Fekete, Danijel Topić, Mario  Primorac, Matej Žnidarec, Ružica Kljajić, Nemanja Mišljenović, Heidi Adrić, Marina Dubravac, Sanja Kelemen, ]]></team_members_names><keywords_hr><![CDATA[aktivni kupac, distribucijska elektroenergetska mreža, kvaliteta električne energije, tržište električne energije, stabilnost sustava ]]></keywords_hr><keywords_en><![CDATA[prosumer, distribution power network, power quality, electricity market, system stability]]></keywords_en><summary_hr><![CDATA[Proizvodnja električne energije iz većine elektrana na obnovljive izvore energije (OIE) uglavnom je promjenjiva i nepredvidiva što uzrokuje poteškoće u planiranju i vođenju elektroenergetske mreže te se masovnom integracijom takvih postrojenja taj učinak povećava. Dosadašnji pasivni kupci električne energije integracijom elektrana na OIE u njihovom vlasništvu postaju kupci s vlastitom proizvodnjom, odnosno postaju aktivni kupci. Razvoj sustava upravljanja energijom aktivnih kupaca je multidisciplinarni proces koji podrazumijeva više aspekata promatranja koji se moraju uzeti u obzir. Svrha ovog projekta je uspostavljanje istraživačke grupe koja će proučavati upravljanje pogonom sustava aktivnog kupca i distribucijske mreže s četiri aspekata promatranja: prvi je maksimizacija zarade aktivnog kupca sudjelovanjem na energetskom tržištu i tržištu pomoćnih usluga, drugi je optimizacija pogona same distribucijske mreže s ciljem smanjenja gubitaka i održavanja poželjnih strujno-naponskih prilika u mreži, treći je smanjenje utjecaja na kvalitetu električne energije i četvrti aspekt promatranja je održavanje naponske i frekvencijske stabilnosti mreže u slučaju priključenja većeg broja aktivnih kupaca na distribucijsku mrežu. Ciljevi projekta obuhvaćaju izrađene simulacijske modele za analizu međudjelovanja distribucijske mreže i sustava aktivnih kupaca te razvijene optimizacijske algoritme za određivanje optimalnog pogona uređaja aktivnih kupaca i distribucijske mreže za različite aspekte promatranja. Rezultati projekta doprinijeti će mogućnosti velike integracije aktivnih kupaca u distribucijsku mrežu uz očuvanje frekvencijske i naponske stabilnosti sustava te propisane razine kvalitete električne energije. Uz to, omogućit će aktivnim kupcima određivanje plana angažiranja njihovih uređaja s ciljem optimalne zarade na tržištu električne energije te tržištu pomoćnih usluga. ]]></summary_hr><summary_en><![CDATA[Electricity generation from the most of renewable energy sources (RES) based power plants is generally variable and unpredictable which causes difficulties in the electricity grid planning and operation, while this effect magnifies even more by the massive integration of such power plants. Previous passive consumers by integration of RES based power plants in their ownership are becoming consumers with their own production, or so-called prosumers. The development of a prosumer energy management system is a multidisciplinary process that involves multiple aspects that must be considered. The purpose of this project is to establish a research group to study the operation of a prosumer system and distribution network within four aspects of observation: first is maximizing the prosumers profit by participating on the electricity and ancillary services markets, second is the optimization of the distribution network operation with objectives of power losses minimization and maintaining the desired loading and voltage levels in the network, third is to reduce the impact on the power quality and the fourth aspect is to maintain the voltage and frequency stability of the network when large number of prosumers are connected to the distribution network. The objectives of the project include developed simulation models for analyzing the interactions of the distribution network and the prosumer system, as well as the developed optimization algorithms for determining the optimum drive of the prosumer devices and distribution network for various aspects of observation. The results of the project will contribute to the possibility of large-scale integration of prosumers in the distribution network while maintaining the frequency and voltage stability of the system and the prescribed level of power quality. In addition, it will enable prosumers to determine the operation plan for their devices in order to optimize their earnings in the electricity and ancillary services markets.]]></summary_en></project><project>
<id>10007</id><title_hr><![CDATA[Forenzička identifikacija ljudskih ostataka analizom MSCT snimaka]]></title_hr><title_en><![CDATA[Forensic identification of human remains using MSCT image analysis]]></title_en><user_id>1109</user_id><user_firstLast_name>Ivana Kružić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2020-02</proposal_call><code>UIP-2020-02-7331</code><acronim><![CDATA[CTforID]]></acronim><duration>30.04.2021 - 29.04.2026</duration><status>U tijeku</status><financ_value>145.391,42 eur</financ_value><scie_area_hr>Interdiciplinarne znanosti, Biomedicina i zdravstvo, Društvene znanosti, Humanističke znanosti, </scie_area_hr><scie_area_en>Interdisciplinary scientific area, Biomedicine and health sciences, Social sciences, Humanities, </scie_area_en><scie_field_hr>Kliničke medicinske znanosti, Sigurnosne i obrambene znanosti, Etnologija i antropologija, </scie_field_hr><scie_field_en>Clinical sciences, Security and defense sciences  , Ethnology and anthropology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu]]></institution_hr><institution_en><![CDATA[University of Split]]></institution_en><team_members_id>22644, 22538, 13173, 26668, 621, 865021, 25943, </team_members_id><team_members_names><![CDATA[Marija Ćavar Borić, Ivan Jerković, Krešimir Dolić, Danijela Budimir Mršić, Željana Bašić, Tina Bareša, Elvira Krešić, ]]></team_members_names><keywords_hr><![CDATA[forenzična identifikacija, MSCT, analiza slike, procjena spola, procjena dobi, populacijske specifičnosti, ljudski ostaci]]></keywords_hr><keywords_en><![CDATA[ forensic identification, MSCT, image analysis, sex estimation, age estimation, population specificity, human remains]]></keywords_en><summary_hr><![CDATA[U ovom projektu će se razvijati unutar novoga područja u forenzičnoj i biološkoj antropologiji koji se danas često naziva „virtualnom antropologijom“. Ona obuhvaća novi znanstveni pristup koji se temelji na objedinjavanju klasične forenzičke antropologije, tehnologije medicinskog snimanja i radiologije, kao i računalnih znanosti. Projekt će se temeljiti na medicinskim snimkama iz „Virtualne baze MSCT snimaka Split, “ osnovane 2017. g. kroz suradnju između Laboratorija za forenzičnu i biološku antropologiju, Sveučilišnog odjela za forenzične znanosti (Forenzika) i Kliničkog zavoda za intervencijsku i dijagnostičku radiologiju KBC-a Split (Radiologija). Istraživanje podataka iz zbirke i unapređenje metodologije omogućit će razvoj metoda forenzičke identifikacije, kao i njezino neograničeno proučavanje u budućnosti. Radna hipoteza projekta je da će se značajno poboljšati preciznosti forenzičke identifikacije kroz definiranje novih populacijsko specifičnih standarda koristeći virtualnu bazu MSCT snimki.  Projektom se planira uspostaviti istraživački laboratorij za digitalnu forenzičku antropologiju na populaciji (RH) i unaprijediti metodologiju procjenjivanja spola, dobi i specifičnih populacijskih obilježja (RH) za potrebe forenzičke identifikacije primjenom novih tehnologija. Kroz projekt će se razviti nova i unaprijediti postojeća metodologija u području forenzičke identifikacije ljudskih ostataka i na taj način doprinijeti ubrzanom razvoju unutar područja forenzičke identifikacije, ali i multisektorskom transferu znanja i vještina. Rezultati istraživanja će direktno utjecati na razvoj struke u forenzičkoj identifikaciji jer će se razviti novi standardi koji će biti primjenjivi u svakodnevnom znanstvenom i stručnom radu (Identifikacija žrtava Domovinskog i II. svjetskog rata na području RH). ]]></summary_hr><summary_en><![CDATA[This project will be developed within a new field in forensic and biological anthropology -&#39;&#39;virtual anthropology&#39;&#39;. It includes a new scientific approach based on the unification of classical forensic anthropology, medical imaging technology, and radiology as well as computer science. The project will be based on medical images from the &#39;&#39;Scan and Multislice CT Angiogram (MSCT) Split Virtual Database&#39;&#39;, established in 2017 through the collaboration between the Forensic and Biological Anthropology Laboratory, the Forensic Science Department of Forensics and the Clinical Institute for Interventional and Diagnostic Radiology of CHC ( Clinical hospital Centre) Split (Radiology). Survey data collection and methodology improvement will enable the development of forensic identification methods as well as its unlimited study in the future. The work hypothesis of the project is that it will significantly improve the precision of forensic identification through defining the new population-specific standards using virtual database of MSCT images.  This project is intended to establish a research laboratory for digital forensic anthropology on the population of the Republic of Croatia and to improve methodology of sex, age and specific population characteristics in the Republic of Croatia for forensic identification by applying new technologies. Through the proposed project new methodology in the area of forensic identification of human remains will be developed and the existing methodologies will be improved. The project will contribute to faster development in forensic identification discipline as well as to the multi-sector transfer of knowledge and skills. The results of the research will directly affect the development of the forensic identification because the newly developed standards will be applicable in everyday scientific and professional work]]></summary_en></project><project>
<id>10014</id><title_hr><![CDATA[Mikroplastika u vodi; sudbina, ponašanje i uklanjanje]]></title_hr><title_en><![CDATA[Microplastics in water; fate and behavior and removal]]></title_en><user_id>1122</user_id><user_firstLast_name>Ana Lončarić Božić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2020-02</proposal_call><code>IP-2020-02-6033</code><acronim><![CDATA[ReMiCRO]]></acronim><duration>15.12.2020 - 14.12.2024</duration><status>Završio</status><financ_value>149.339,70 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Kemijsko inženjerstvo, Interdisciplinarne tehničke znanosti, </scie_field_hr><scie_field_en>Chemical engineering, Interdisciplinary technological sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet kemijskog inženjerstva i tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Chemical Engineering and Technology]]></institution_en><team_members_id>913, 984, 973, 17765, 25650, 3168, 29717, 6729, 3191, 864945, 865030, 25242, </team_members_id><team_members_names><![CDATA[Zlata Hrnjak-Murgić, Hrvoje Kušić, Zvonimir Katančić, Marin Kovačić, Josipa Papac, Panaghiotis Karamanis, bruno Grassl, Bakhtiyor Rasulev, Dionysios Dionysiou, Stefani Tonković, Anamarija Pulitika, Antonija Tomić, ]]></team_members_names><keywords_hr><![CDATA[mikroplastika, onečišćivala koja izazivaju zabrinutost, sudbina i ponašanje, obrada voda, ferati, DFT, QSP/AR]]></keywords_hr><keywords_en><![CDATA[microplastics, contaminants of emerging concern, fate and behavior, water treatment, ferrates, DFT, QSP/AR]]></keywords_en><summary_hr><![CDATA[Mikroplastika (MP) je naziv za sitne čestice polimernog materijala (d<5 mm). Zbog svoje rasprostranjenosti i akumulacije u okolišu, MP postaje razlog globalne zabrinutosti. Malo je poznato o utjecaju MP na zdravlje i okoliš, ali razlozi za zabrinutost su: (i) mikro-veličina čini MP lako dostupnom gutanju i unosu u hranidbeni lanac; (ii) MP je dugo prisutna u okolišu zbog postojanosti i otpornosti prema razgradnji; (iii) MP je praktički nemoguće ukloniti kada jednom dospije u okoliš. Zbog visokog sorpcijskog kapaciteta čestice MP postaju vektori za različita onečišćivala u vodi, uključujući teške metale i nova onečišćivala (eng. contaminats of emerging concern, CEC). Dostupna znanja o sudbini i ponašanju MP u vodi te povezanim rizicima, su nedostatna. Ispusti iz uređaja za pročišćavanje otpadnih voda identificirani su kao putevi ulaska i MP i CECova u okoliš, što jasno ukazuje na potrebu primjene naprednih tehnologija obrade u završnom stupnju.Glavni cilj ReMiCRO projekta jest stvaranje novih znanja potrebnih za razumijevanje sudbine i ponašanja MP u vodi u prisutnosti novih onečišćivala te razvoj rješenja za njihovu učinkovitu obradu. ReMiCRO koristi prednosti sinergije naprednih oksidacijski procesa (eng. advanced oxidation processes AOPs) Fentonovog tipa i ferata(VI). AOPi se temelje na aktivnosti in-situ generiranih radikalskih vrsta I pokazali su se djelotvornima za CECove. Visoka oksidacijska moć ferata(VI) popraćena je s koagulacijskim svojstvima željezo(III) oksida/hidroksida koji nastaju u sustavu. Stoga tehnologije obrade temeljene na AOP-ima Fentonovog tipa i feratima(VI) nude rješenje za rastuće probleme MP i CECova u vodi. Primjena kombiniranog eksperimentalnog i računalnog pristupa omogućava razumijevanje i utvrđivanje utjecaja morfoloških svojstava različitih tipova MP na njihove interakcije s CECovima i teškim metalima u vodi, a time i na učinkovitost procesa obrade vode.]]></summary_hr><summary_en><![CDATA[Microplastics (MPs) are small particles (d<5 mm) of polymer materials. Their persistence and widespread accumulation raised a new concern that reached public awareness. Little is known about the impact of MPs on health and environment but associated concerns are: (i) micro-size makes MPs readily available for ingestion and transfer within the food chain; (ii) MPs are present in environment for a long time due to pervasive nature and resistance to degradation; (iii) MPs are practically impossible to remove from the environment after release. MPs display high sorption capacity thus may serve as vectors for pollutants in water, including heavy metals and contaminants of emerging concern (CECs). The knowledge on fate and behavior of MPs in water and associated risks is rather scarce. Effluents from wastewater treatment plants are identified pathways for both MPs and CECs entering aquatic environment, incentivizing the need for advanced final-stage technologies.The main goal of ReMiCRO is to fill the knowledge gap on fate and behavior of MPs in water matrices containing CEC, and to develop effective treatment solution. ReMiCRO aims to leverage synergy of Fenton-based advanced oxidation processes (AOPs) and ferrate (VI) treatment. AOPs are based on activity of in-situ generated radical species, proven to be effective in degradation of recalcitrant pollutants. The high oxidation power of ferrate(VI) is combined with coagulation properties of the ensuing iron(III) oxide/hydroxide. Hence, both Fenton-based AOPs and ferrate(VI) are promising candidates to cope with emerging problem of MPs and CECs in water. Combined experimental and computational approach will be applied to enlighten interactions and to establish correlation between MPs of different types, sizes and morphologies with different CECs and heavy metal, influencing the fate and behavior of MPs and the effectiveness of the water treatment process.]]></summary_en></project><project>
<id>10017</id><title_hr><![CDATA[Fizikalna kemija procesa na međupovršini mineral/otopina (poli)elektrolita]]></title_hr><title_en><![CDATA[Physical chemistry of processes at mineral/(poly)electrolyte solution interface]]></title_en><user_id>244</user_id><user_firstLast_name>Tajana Begović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2020-02</proposal_call><code>IP-2020-02-9571</code><acronim><![CDATA[POLYMIN2]]></acronim><duration>15.01.2021 - 14.03.2026</duration><status>U tijeku</status><financ_value>131.793,75 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>234, 5334, 836, 1015, 24520, 25924, 865139, 21288, 869883, 869881, </team_members_id><team_members_names><![CDATA[Davor Kovačević, Josip Požar, Danijel Namjesnik, Jasmina Jukić, Tin Klačić, Jozefina Katić, Karla Korade, Juraj Nikolić, Ivor Vavra Plavšić, Tea Juračić, ]]></team_members_names><keywords_hr><![CDATA[minerali, polielektroliti, međupovršine, površinske reakcije, adsorpcija, električni međupovršinski sloj]]></keywords_hr><keywords_en><![CDATA[minerals, polyelectrolytes, interfaces, surface reactions, adsorption, electrical interfacial layer]]></keywords_en><summary_hr><![CDATA[Razumijevanje procesa na površinama minerala suspendiranih u vodenim otopinama elektrolita i polielektrolita važno je za razvijanje teorijskih modela, ali i za brojne primjene. Procesi na površinama često su složeni i međuovisni, a u sklopu ovog projekta primjenom eksperimentalnih metoda i teorijskih modela proučavat će se procesi na površini, u otopini i njihov međusobni utjecaj. Istražit će se procesi na površinama odabranih minerala (TiO2, SiO2 i CaF2) i površinama ovih minerala prekrivenih polielektrolitima različitom kemijskog sastava i različitih gustoća naboja. Kalorimetrijskim, potenciometrijskim, elektrokinetičkim i elektrokemijskim metodama ispitat će se utjecaj ionske jakosti i sastava otopine na površinske reakcije. Primjenjivost eksperimentalnih tehnika povećat će se sparivanjem različitih eksperimentalnih metoda. Istražit će se utjecaj adsorbiranih polielektrolita na svojstva električki nabijenih površina minerala i nanočestica. Koloidna stabilnost suspenzija koje sadrže ispitivane minerale usporedit će se s koloidnom stabilnošću minerala prekrivenih polielektrolitima. Ispitat će se kemijska reaktivnost i otapanje minerala prekrivenih polielektrolitima. Ova istraživanja uključuju razvoj modela koji opisuje stanje na površini i utjecaj adsorpcije polielektrolita na reakcije na površini. Materijali (minerali i makromolekule) birani su temeljem njihove bioaktivnosti i biokompatibilnih svojstava. Uzevši u obzir uporabu predloženih minerala u industriji hrane, kozmetičkoj i farmaceutskoj industriji, rezultati projektnih istraživanja mogli bi imati i široku primjenu u navedenim područjima djelatnosti. ]]></summary_hr><summary_en><![CDATA[Understanding the processes occurring at mineral surfaces exposed to aqueous electrolyte and polyelectrolyte solutions is important from the fundamental point of view but also for numerous possible applications. Processes at mineral surfaces are often complex and interdependent. Within the proposed project the phenomena taking place at surfaces, in solution, and their interplay will be studied using experimental methods and applying theoretical models. The selected minerals (TiO2, SiO2 and CaF2) and the surfaces of these minerals covered with polyelectrolytes of different composition, charge and charge densities will be investigated. The chemical stability of the mineral surfaces and the surface dissolution will be studied. The influence of ionic strength and solution composition on aforementioned processes will be investigated by calorimetric, potentiometric, electrokinetic and electrochemical methods. One of the objectives of the project is to couple different experimental methods in order to simultaneously measure different parameters that characterize surface reactions. The influence of the adsorbed polyelectrolytes on surface reactions and properties of electrically charged minerals will be explored. A model which describes surface equilibrium states and the effect of polyelectrolyte adsorption on transformation and dissolution of the mineral will be proposed. Importantly, materials (minerals and macromolecules) which will be investigated were selected on the basis on their bioactivity and biocompatibility. This is due to their frequent use in food, cosmetic and pharmaceutical industry, which opens a path for numerous possible applications of results obtained within the frame of proposed project research.]]></summary_en></project><project>
<id>10020</id><title_hr><![CDATA[Regulacija mitofagije posredovane receptorom u  stanicama eritroidne loze]]></title_hr><title_en><![CDATA[Regulation of receptor-mediated mitophagy in erythroid lineage cells]]></title_en><user_id>62</user_id><user_firstLast_name>Ivana Novak Nakir</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2020-02</proposal_call><code>IP-2020-02-3883</code><acronim><![CDATA[MitoReg]]></acronim><duration>13.09.2021 - 12.06.2026</duration><status>U tijeku</status><financ_value>199.084,21 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Split School of Medicine]]></institution_en><team_members_id>23240, 26047, 26748, 865165, 17855, 869830, 20262, </team_members_id><team_members_names><![CDATA[Irena Drmić Hofman, Vladimir Rogov, Joern Dengjel, Ana Rožić, Mija Marinković, Tina Domjanović, Marko Žarak, ]]></team_members_names><keywords_hr><![CDATA[autofagija, mitofagija, fosforilacija, receptor NIX, eritroidna loza]]></keywords_hr><keywords_en><![CDATA[autophagy, mitophagy, phosphorylation, NIX receptor, erythroid lineage]]></keywords_en><summary_hr><![CDATA[Održavanje kvalitete mitohondrija i homeostaze u stanici ovisno je o mitofagiji, specijaliziranom obliku autofagije kojom se selektivno uklanjaju mitohondriji. Za ovaj bazični stanični proces uklanjanja oštećenih ili nepotrebnih mitohondrija potrebna su dva ključna događaja: aktivacija mehanizma autofagije i obilježavanje mitohondrija za razgradnju. Obilježavanje mitohondrija, koji će se razgrađivati, ostvaruje se ili PINK1-PARKIN putem ili putem receptora mitofagije. Receptorom posredovana mitofagija naročito je proučavana u retikulocitima u kojima je nužna za sazrijevanje u eritrocite te u stanicama retine. Za oba diferencijacijska slučaja nužno je ostvariti vezu između receptora mitofagije NIX i proteina LC3/GABARAP koji su sastavni dio autofagosomalne vezikule za razgradnju. U fokusu ovog istraživanja je proučavanje mehanizama mitofagije, s naglaskom na mitofagiju posredovanu receptorom u stanicama eritroidne loze kako bismo što bolje razumjeli terminalnu diferencijaciju eritrocita. Naši dosadašnji rezultati pokazuju da su fosforilacija i dimerizacija receptora NIX ključne za njegovu aktivaciju, a time i pokretanje mitofagije. Ovim projektom detaljno ćemo analizirati proteinske interakcije kinaza i fosfataza receptora NIX identificiranih u laboratoriju te razjasniti njihovo djelovanje u stanicama koristeći se biokemijskim metodama i metodama molekularne i stanične biologije. Nadalje, istražit ćemo i nove interaktore receptora NIX i drugih receptora mitofagije s naglaskom na mitohondrijske proteine masenom spektrometrijom, kako bismo odgonetnuli signalne puteve koji pokreću mitofagiju. Finalno, analizom statusa autofagije i mitofagije u stanicama koštane srži pacijenata s mijeloproliferativnom bolesti policitemija vera metodama qPCR, western blota i protočne citometrije pokušat ćemo odgonetnuti moguću ulogu ovih procesa u nastajanju bolesti čime bi se otvorio put razumijevanju uloge autofagije u abnormalnoj diferencijaciji eritroidnih stanica. ]]></summary_hr><summary_en><![CDATA[Quality control maintenance of mitochondria and homeostasis in the cell is dependent on mitophagy, a specialized form of the autophagy, that selectively removes mitochondria. Two key steps are indispensable for this basic cellular process of damaged or unnecessary mitochondria removal: induction of the autophagy machinery and priming of mitochondria destined for degradation. Mitochondrial priming is mediated by PINK1-PARKIN pathway or through specialized mitochondrial receptors. Receptor-mediated mitophagy is extensively studied in reticulocytes where mitophagy is indispensable for their maturation into erythrocytes, as well as in retina. For both differentiation moments, it is necessary to establish a link between the NIX and LC3/GABARAP adaptors, which are an integral part of the autophagosomal vesicle needed for degradation. The focus of this project proposal is to study mitophagy mechanisms, with emphasis on receptor-mediated mitophagy, in erythroid cell line to better understand terminal erythrocyte differentiation. Our previous results show that phosphorylation and dimerization of NIX are key for receptor activation, and therefore the initiation of mitophagy. This project will in detail analyze the protein interactions of NIX with its kinases and phosphatases identified in the lab and clarify their activity in cells using biochemical, molecular and cellular biology methods. Furthermore, we will investigate new interaction partners of NIX and other mitophagy receptors with emphasis on mitochondrial proteins by mass spectrometry methods to unveil signaling pathways that trigger mitophagy. Finally, by analyzing the status of autophagy and mitophagy in bone marrow cells of myeloproliferative disease patients using quantitative PCR, Western blot and flow cytometry, we will tackle the possible role of these processes in the onset of the disease and open the door to grasp the role of autophagy in abnormal differentiation of erythroid cells. ]]></summary_en></project><project>
<id>10023</id><title_hr><![CDATA[Karakterizacija radiofotoluminiscentnih dozimetara u poljima teško nabijenih čestica]]></title_hr><title_en><![CDATA[Characterisation of RadioPhotoLuminescent dosimeters for measurements in Heavy Charged Particle fields]]></title_en><user_id>4769</user_id><user_firstLast_name>Marija Majer</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2020-02</proposal_call><code>IP-2020-02-3593</code><acronim><![CDATA[RPLforHCP]]></acronim><duration>15.01.2021 - 14.01.2025</duration><status>Završio</status><financ_value>131.926,47 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Interdisciplinarne prirodne znanosti, Fizika, </scie_field_hr><scie_field_en>Interdisciplinary natural sciences, Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>230, 19098, 11070, 29551, 865443, 867162, 868740, 869851, </team_members_id><team_members_names><![CDATA[Željka Knežević Medija, Marijana Nodilo, Hrvoje Brkić, Liliana Stolarczyk, Luka Pasariček, Fereshte Saheli, Mercedes Horvat, Jose Vedelago, ]]></team_members_names><keywords_hr><![CDATA[dozimetrija zračenja, RPL detektor, polja teško nabijenih čestica, dozimetrijska karakterizacija, LET, radioterapija teško nabijenim česticama]]></keywords_hr><keywords_en><![CDATA[radiation dosimetry, RPL detector, heavy charged particle fields, dosimetric characterisation, LET,  heavy charged particle radiotherapy]]></keywords_en><summary_hr><![CDATA[Brojna bazična te primijenjena istraživanja su pokazala da je radiofotoluminiscentna (RPL) dozimetrija pouzdana dozimetrijska metoda za mjerenja u poljima fotona i elektrona. No, u poljima teško nabijenih čestica (HCP), dozimetijska karakterizacija, pogotovo ovisnost odziva detektora o energiji i linearnom prijenosu energije (LET) još uvijek nije dovoljno istražena. Posebni izazovi su upotreba RPL dozimetara u radioterapiji teško nabijenim česticama  te dozimetriji u svemiru i za oba interes jako raste. Zbog sve veće važnosti čestične radioterapije u liječenju karcinoma, nužno je istražiti dozimetrijske metode pri mjerenjima u poljima teško nabijenih čestica i to ne samo duž putanje primarne čestice nego i u okolnom području zbog spoznaje da ozračivanje zdravog tkiva može povećati vjerojatnost nastanka sekundarnog karcinoma. Za istraživanja doza izvan tumora, kao i za &#39;&#39;audite&#39;&#39; snopova, mali pasivni dozimetri, jednostavni za rukovanje (kao npr. RPL) su vrlo prikladni.Predloženo istraživanje doprinjet će razumijevanju dozimetrijskih karakteristika RPL dozimetara za mjerenja i primjenu u poljima teško nabijenih čestica. Sustavno će se ispitati ovisnost odziva detektora o LET-u upadne čestice: najprije koristeći različite HCP-snopove zaustavnih energija dobivenih u akceleratorskom postrojenju na Institutu, a zatim u radioterapijskom centru koristeći terapijske protonske snopove visokih energija. Također, ispitat će se reproducibilnost, slabljene signala i dozna ovisnost. U svim eksperimentima koristit će se i termoluminiscentni dozimetri. Rezultati će se usporediti s dobivenim rezultatima za RPL detektore kao i s dostupnim rezultatima u literaturi. Za sve eksperimente napravit će se teorijski model i Monte Carlo (MC) simulacija  te će se  svi eksperimentalni rezultati usporediti s rezultatima dobivenim Monte Carlo (MC) izračunima.]]></summary_hr><summary_en><![CDATA[Radiophotoluminescent (RPL) dosimetry is proved in many studies to be a reliable dosimetry method successfully used in a large scale for many applications in photon and electron fields. Still, dosimetric characterisation and especially energy and linear energy transfer (LET) dependence of the response in heavy charged particle (HCP) fields have not yet been fully investigated. The particular challenge and lately increasing interest is the use of RPLs in HCP radiotherapy and space dosimetry. The increasing role of HCP radiotherapy in the cancer treatment causes the need to thoroughly investigate the dosimetry methods for HCP measurements not only along the Bragg curve of the primary particle but also in the distal (out-of-field) region due to knowledge that irradiation of the healty tissue, caused by stray radiation, can increase risk of second cancer. For out-of-field phantom studies or beam audits, passive dosimeters of small size and simple in handling (such are RPLs) are very suitable. Proposed research will improve understanding of the dosimetric characteristics of RPLs for their use for measurements in the HCP fields. Particularly, LET dependence of the RPL glass detector response will be systematically investigated: firstly at the RBI accelerator facility using low energy HCP beams and secondly in real conditions at the proton radiotherapy center by using high energy therapeutic proton beams. Also, dosimetric characterisation (reproducibility, fading and dose dependance) will be investigated. All experimental results will be compared with Monte Carlo simulation results. In addition the measurements will be done also with thermoluminescent (TL) dosimeters and comparison with RPLs and published data will be made. ]]></summary_en></project><project>
<id>10027</id><title_hr><![CDATA[Napredne metode proizvodnje i transporta zelenog vodika]]></title_hr><title_en><![CDATA[Advanced methods of green hydrogen production and its transportation]]></title_en><user_id>20175</user_id><user_firstLast_name>Ankica Kovač</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2020-02</proposal_call><code>UIP-2020-02-7332</code><acronim><![CDATA[H2LAB / H2LAB]]></acronim><duration>11.01.2021 - 10.01.2026</duration><status>U tijeku</status><financ_value>240.906,88 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, Elektrotehnika, Kemijsko inženjerstvo, Interdisciplinarne tehničke znanosti, </scie_field_hr><scie_field_en>Mechnical engineering, Electrical engineering, Chemical engineering, Interdisciplinary technological sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>18920, 26266, 18905, </team_members_id><team_members_names><![CDATA[Željko Penga, Matej Paranos, Tessa Uroić, ]]></team_members_names><keywords_hr><![CDATA[Vodik, Elektrolizator, Sunčeva energija, Gorivni članak, Transport vodika]]></keywords_hr><keywords_en><![CDATA[Hydrogen, Electrolyzer, Solar energy, Fuel Cell, Hydrogen transportation]]></keywords_en><summary_hr><![CDATA[U zadnje vrijeme neki poznati znanstvenici u području klimatskih promjena izražavaju svoju duboku zabrinutost, pa čak i svojevrsnu apatičnost, kada je u pitanju mogućnost ljudske rase da ih preživi. Porast koncentracije CO2 u atmosferi uzrokuje globalno zagrijavanje mora, kopna i atmosfere. Do sada, nezabilježen skok koncentracije CO2 u atmosferi započinje negdje 1850. g. kada je koncentracija iznosila oko 285 ppm, 2014. g. prerasta granicu od 400 ppm CO2, a danas, u trenutku pisanja ovog projektnog prijedloga, iznosi već oko 414 ppm. Dakle, zahtjeva se drastični prijelaz na OIE i vodik prije 2035. godine ako se želi zadržati globalno zagrijavanje ispod 2 °C u odnosu na predindustrijsko doba. Razvoj i komercijalizacija jeftinog uređaja koji bi mogao osigurati vodik korištenjem OIE znatno bi ubrzao napuštanje energetskih tehnologija zasnovanih na fosilnim gorivima koji danas čine osnovu energetskih sustava. Proizvodnja vodika putem elektrolize vode korištenjem čiste električne energije iz OIE zadnjih godina dolazi u prvi plan. Zato je izuzetno važno povećati učinkovitost postojećih procesa i elektrolizatora, te pojednostavljenjem konstrukcije i uvođenjem novih materijala pojeftiniti investicijsku vrijednost sustava i cijenu njegovog održavanja. Hipoteza H2LAB-a je da za transport tako proizvedenog vodika mogu poslužiti postojeći plinovodi na način da se 10-12% vodika miješa na ulazu u cjevovod i nakon transporta mješavine, na izlazu se mogu taj plin i vodik razdvojiti pomoću specijalnih membrana koje su propusne samo za vodik. Na ulazu se plin i vodik miješaju u zadanim količinama, na izlazu se eksperimentira s armaturom u kojoj je glavni dio membrana. Metode koje će se koristiti su eksperimentalne i metode simulacije. Metode simulacije uključuju simulacijske pakete CFD OpenFOAM, Fluent, modeFrontier i MATLAB/Simulink. Projekt će rezultirati novim teorijskim i praktičnim spoznajama o sinergijskim efektima unutar elektrolizatora i transporta vodika.]]></summary_hr><summary_en><![CDATA[Recently, some well-known scientists in the field of climate change express their deep concern and even apathy when it comes to the humans ability to survive. An increase in the concentration of CO2 in the atmosphere causes global warming of the sea, land and atmosphere. So far, the unprecedented jump in CO2 concentration begins in 1850 when the concentration was about 285 ppm, in 2014 it exceeded the limit of 400 ppm CO2, and today, at the moment of writing this proposal, it is already about 414 ppm. Thus, a drastic transition to RES and hydrogen before 2035 is required if global warming want to be kept below 2 °C in comparison to pre-industrial times. The development and commercialization of a low-cost device that could provide hydrogen using RES would significantly accelerate the abandonment of fossil fuel-based energy technologies. Hydrogen production through the water electrolysis using clean electricity from RES in recent years has come to the fore. That is why it is extremely important to increase the efficiency of existing processes and electrolyzers, and by simplifying the construction and introducing new materials, reduce the investment value of the system and the cost of its maintenance. The hypothesis of H2LAB is that existing gas pipelines can be used to transport produced hydrogen by mixing 10-12% of hydrogen at the inlet of the pipeline grid. After transporting the mixture, the gas and hydrogen can be separated at the outlet by special membranes that are permeable only for hydrogen. At the inlet, gas and hydrogen will be mixed in the set quantities, and the armature will be investigated at the outlet where the main part are membranes. The methods that are going to be used are experimental and simulation methods. Simulation methods include CFD OpenFOAM, Fluent, modeFrontier and MATLAB/Simulink simulation packages. The project will result in new theoretical and practical insights into the synergistic effects within electrolyzers and hydrogen transport.]]></summary_en></project><project>
<id>10033</id><title_hr><![CDATA[Otkriće i razvoj novih biološki aktivnih kvaternih amonijevih spojeva derivata kinuklidina]]></title_hr><title_en><![CDATA[Discovery and development of new bioactive quaternary ammonium compounds derived from quinuclidine]]></title_en><user_id>6130</user_id><user_firstLast_name>Matilda Šprung</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2020-02</proposal_call><code>UIP-2020-02-2356</code><acronim><![CDATA[QACBioAct]]></acronim><duration>01.02.2021 - 31.07.2026</duration><status>U tijeku</status><financ_value>263.775,43 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, Biologija, </scie_field_hr><scie_field_en>Chemistry, Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Science]]></institution_en><team_members_id>6683, 6108, 864986, 865120, 872889, </team_members_id><team_members_names><![CDATA[Lucija Krce, Barbara Soldo, Doris Crnčević, Antonio Sabljić, Josip Tomaš, ]]></team_members_names><keywords_hr><![CDATA[kvaterni amonijevi spojevi, kinuklidin, derivati kinuklidina, biološka aktivnost, mehanizam rezistencije]]></keywords_hr><keywords_en><![CDATA[quaternary ammonium compounds, quinuclidine, quinuclidine derivatives, biological activity, resistance mechanism]]></keywords_en><summary_hr><![CDATA[Kvaterni amonijevi spojevi (QACs) su amfipatske molekule antimikrobnih svojstava s primjenom u brojnim industrijama. Spojevi benzalkonijev klorid, cetilpiridinijev klorid i didecildimetilamonijev klorid česte su komponente mnogih antiseptika. S obzirom da su QACs amfipatski spojevi s djelovanjem na bakterijsku membranu, dugo se smatralo da je rezistencija na ove spojeve gotovo nemoguća. Međutim, novija istraživanja ukazuju da je rezistencija na QACs široko rasprostranjena zbog Qac efluks pumpi, ali i drugih, još nerazjašnjenih mehanizama otpornosti. Naša dosadašnja istraživanja pokazala su kako derivati kinuklidina mogu poslužiti kao molekulska okosnica za razvoj novih biološki aktivnih QACs. Cilj je ovog istraživanja sintetizirati nove derivate kinuklidin-3-amida i njihove QACs te im ispitati biološku aktivnost (MIC i MBC prema izabranom panelu bakterija, inhibitorno djelovanje na bakterijske biofilmove, antioksidacijsku aktivnost te citotoksičnost). Djelovanje biološki aktivnih spojeva na staničnu membranu, ispitat će se mjerenjem propusnosti membrane za propidijev jodid i analizom uzorka bakterijskih stanica mikroskopijom atomskih sila. Kako bi se utvrdio mogući utjecaj spojeva na ekspresiju Qac efluks pumpi, ispitat će se njihova interakcija s ciljnim makromolekulama metodom termoforeze. Razvoj rezistencije i ekspresija faktora virulencije u uzorcima bakterijskih kultura izloženih antimikrobnim spojevima, analizirat će se masenom spektrometrijom. Očekivani rezultat predloženog projekta su novi QACs, derivati kinuklidina, značajnih bioloških svojstava, koji bi mogli imati primjenu u farmaceutskoj, prehrambenoj i poljoprivrednoj industriji.]]></summary_hr><summary_en><![CDATA[Quaternary Ammonium Compounds (QACs) are amphiphilic molecules of antimicrobial properties with application in numerous industries. Compounds such as benzalkonium chloride, cetylpyridinium chloride and didecildimethylammonium chloride are common components of many antiseptics. Since QACs are amphiphilic molecules that act on the bacterial membrane, it was long believed that resistance toward these compounds is virtually impossible. However, recent studies suggested that resistance to QACs is widespread not only due to Qac efflux pumps, but also due to another, yet unknown mechanism of resistance. Our previous studies have shown that quinuclidinium containing derivatives can serve as a molecular scaffold for development of new QACs. The aim of this study is to develop new derivatives of quinuclidin-3-amide and their QACs, and to investigate their biological activity (MIC and MBC against the selected panel of bacteria, antibiofilm, antioxidative activity and cytotoxicity). The mode of action for selected bioactive molecules will be investigated by measuring membrane permeability for propidium iodide and by analysing a bacterial sample with atomic force microscope. To determine the possible influence of compounds on expression of Qac efflux pumps, their interaction with targeted macromolecules will be investigated by thermophoresis. The development of resistance and expression of virulence factors in samples of bacterial cultures exposed to antimicrobial compounds will be analysed by mass spectrometry. The expected outcome of the proposed project is discovery of new quinuclidinium derived bioactive QACs, with potential application in pharmaceutical, food and agricultural industries.]]></summary_en></project><project>
<id>10034</id><title_hr><![CDATA[Institucionalizacija moderne građanske glazbene kulture u 19. stoljeću na području civilne Hrvatske i Vojne krajine]]></title_hr><title_en><![CDATA[Institutionalization of modern bourgeois musical culture in the 19th century in civil Croatia and Military Border]]></title_en><user_id>19568</user_id><user_firstLast_name>Stanislav Tuksar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2020-02</proposal_call><code>IP-2020-02-4277</code><acronim><![CDATA[MusInst19]]></acronim><duration>22.11.2021 - 21.04.2026</duration><status>U tijeku</status><financ_value>52.683,79 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Interdisciplinarne humanističke znanosti, Povijest, Znanost o umjetnosti, </scie_field_hr><scie_field_en>Interdisciplinary humanities, History, Arts, </scie_field_en><institution_hr><![CDATA[Hrvatska akademija znanosti i umjetnosti]]></institution_hr><institution_en><![CDATA[Croatian Academy of Sciences and Arts]]></institution_en><team_members_id>7808, 29577, 29643, 868196, </team_members_id><team_members_names><![CDATA[Vjera Katalinić, Lucija Konfic, Petra Babić Babić, Marija Benić Zovko, ]]></team_members_names><keywords_hr><![CDATA[institucionalizacija, glazba, privatna inicijativa, politika, civilna Hrvatska, Vojna krajina, 19. stoljeće]]></keywords_hr><keywords_en><![CDATA[institutionalization, music, private initiative, politics, civil Croatia, Military Border, 19th century]]></keywords_en><summary_hr><![CDATA[Proces preobrazbe i modernizacije društva u civilnoj Hrvatskoj  do njezina sjedinjenja s maticom zemljom 1881. i nakon njega bio je dugotrajan i vodio je k postupnom stvaranju moderne hrvatske nacije i njezine integracije u cjelini. Pojave na području kulture, uključujući i umjetničku glazbu, bile su dio tog procesa, reflektirajući ga na specifičan način i istodobno mu pridonoseći svojim zasebnim sadržajima na idejnom, emotivnom i tvarnom planu. Dosad su takva istraživanja na području umjetnosti provedena uglavnom u sferi književnosti. Na području glazbe te su pojave istraživali od kraja 19., tijekom čitavog 20. i početkom 21. stoljeća pojedini glazbeni povjesničari, pri čemu su se neki među njima bavili pojedinačnim pojavama (ustanove, ličnosti), a drugi iznosili prve sintetičke poglede. No, hrvatska historijska muzikologija tek je na pragu poimanja jedne socijalne povijesti glazbe, a ovaj projekt ima ambiciju da upravo istražujući, dovodeći u vezu i vrednujući privatnu i javnu, individualnu i društvenu komponentu glazbene kulture dosadašnje spoznaje i obrađenu povijesnu faktografiju nadogradi novim socijalno-povijesnim artefaktima, uvidima i sintezama na planovima primarne glazbene produkcije (kompozicija), njezine reprodukcije (izvoditeljska praksa), društvene recepcije (odjeci i vrednovanje u javnosti) i organizacije (tipovi privatnih i javnih inicijativa, glazbeno školstvo). Dokumentacija o tim aspektima trenutačno je slabo pristupačna, dobrim dijelom neistražena i uopće nije sistematski prikazana u znanstvenoj i široj javnosti, a ovim se projektom po prvi put nastoji pružiti relevantna i znanstveno obrađena materijalno-dokumentarna baza za poimanje glazbene komponente u stvaranju kulture nastajućeg građanskog društva u kontinentalnoj Hrvatskoj.]]></summary_hr><summary_en><![CDATA[The process of transformation and modernization of society in civil Croatia and the Military Border until its joining the civil Croatia in 1881, and after this date, was a long-term process which led to the gradual creation of modern Croatian nation and to its integration as a whole. Phenomena in culture, including art music, made part of this process, reflecting it in a specific way and at the same time contributing to it with their particular contents in ideas, emotions and in the sphere of reality. Up to now research in the areas of arts was effectuated mostly in literature. In music such phenomena were investigated since the end of the 19th century throughout the 20th up to the beginning of the 21st century.by music historians. In this, some of them dealt with single phenomena (institutions, personalities) and others created first synthetic views. Since Croatian historical musicology is still at the beginning of understanding a social history of its music, this project intends – by investigating and bringing together and evaluating private and public, individual and social components of musical culture – to enlarge existing understanding and already elaborated historical facts by newly discovered socio-historical artefacts, insights and syntheses in areas of primary music production (compositions), its performing practices, social reception (assessment in public media) and organization (types of private and public initiatives, musical education). Documentation on these aspects is currently poorly accessible, in greater part unexplored and not at all systematically presented to scholarly world and the public sphere at large. Thus this project intends for the first time to offer new, as yet unknown, relevant and scholarly elaborated material and documentary basis for understanding the role of musical component in the creation of the emerging bourgeois society in continental Croatia during the 19th century.]]></summary_en></project><project>
<id>10035</id><title_hr><![CDATA[Prostorni i vremenski uzorci genetičke raznolikosti kalanoidnih kopepoda i pelagičkih plaštenjaka u Jadranu]]></title_hr><title_en><![CDATA[Spatial and temporal patterns of genetic diversity of calanoid copepods and pelagic tunicates in the Adriatic]]></title_en><user_id>3160</user_id><user_firstLast_name>Rade Garić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2020-02</proposal_call><code>UIP-2020-02-3907</code><acronim><![CDATA[SpaTeGen]]></acronim><duration>01.03.2021 - 31.08.2026</duration><status>U tijeku</status><financ_value>245.537,20 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, Interdisciplinarne prirodne znanosti, </scie_field_hr><scie_field_en>Biology, Interdisciplinary natural sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Dubrovniku]]></institution_hr><institution_en><![CDATA[University of Dubrovnik]]></institution_en><team_members_id>1519, 390, 543, 866654, 869800, </team_members_id><team_members_names><![CDATA[Marijana Hure, Ana Baričević, Mirta Smodlaka Tanković, Nika Pasković, Marija Rusković, ]]></team_members_names><keywords_hr><![CDATA[Jadransko more, metabarkodiranje, kalanoidni kopepodi, pelagički tunikati, Appendicularia, Thaliacea, dubokomorske vrste]]></keywords_hr><keywords_en><![CDATA[Adriatic Sea, metabarcoding, calanoid copepods, pelagic tunicates, Appendicularia, Thaliacea, deep sea species]]></keywords_en><summary_hr><![CDATA[Kalanoidni kopepodi i pelagički tunikati su dvije najbrojnije skupine mezozooplanktona sa najvećim utjecajem na pelagičke ekosustave. Te dvije skupine imaju najveći utjecaj na fitoplankton kroz predaciju kojom utječu na tijek i jačinu cvjetanja fitoplanktona. Osim toga su i glavni sekundarni proizvođači te važni izvor hrane višim trofičkim razinama. Genetička raznolikost ovih dviju skupina se nije do sada istraživala u južnom Jadranu, a za planktonske tunikate je jako malo podataka i na svjetskoj razini. Da bismo sveobuhvatno istražili genetičku raznolikost ovih skupina u Jadranu koristit ćemo metodu metabarkodiranja. Metabarkodiranje je revolucionarna metoda za procjenu biološke raznolikosti i određivanje sastava zajednica sekvenciranjem ortolognih sekvenca DNA gotovo svih vrsta unutar uzorka pomoću tehnika visokopropusnog paralelnog sekvenciranja (VPS). U tu svrhu izradit ćemo bazu podataka važnih gena za barkodiranje kao što su COI, 18S, kao i ITS regija za kalanoidne kopepode i pelagičke plaštenjake, koja će poslužiti kao referenca za buduće studije. Cilj našeg projekta je korištenje VPS tehnika za genetičku karakterizaciju populacija jadranskog mezozooplanktona, utvrđivanje razlika u njihovom genetičkom sastavu između različitih dijelova Jadrana, koji se razlikuju po dubini, razini sezonskih promjena u slanosti i temperaturi (kao što su sjeverni i južni Jadrana) i udaljenosti od obale. Posebna će se pažnja posvetiti genetičkoj karakterizaciji populacija dubokog mora kao i populacija u zatvorenim obalnim sustavima za koje je poznato da sadrže zooplanktonske populacije jedinstvenog genetičkog sastava, poput Mljetskih jezera. Projekt će prikupiti opsežne podatke o stanju i interakcijama jadranskih zooplanktonskih zajednica koji će poslužili kao osnova za bolje upravljanje okolišem. Nadalje, procijenit ćemo potencijal VPS-a kao tehnike praćenja alohtonih vrsta, njihovo širenje i utjecaj na zooplanktonske zajednice.]]></summary_hr><summary_en><![CDATA[Calanoid copepods and pelagic tunicates are the two most abundant groups of mesozooplankton with highest impact on pelagic ecosystems. They are main grazers of phytoplankton important for their ability to modulate phytoplankton blooms. They are also major secondary producers and important source of food for higher trophic levels. Genetic diversity of these groups was not investigated in the South Adriatic and for pelagic tunicates there is very few data in general. In order to investigate large scale genetic diversity of these groups in the Adriatic we plan to use metabarcoding approach. Metabarcoding is revolutionary method for assessing biodiversity and determining community composition by sequencing orthologous DNA regions of virtually all species within the sample using massive parallel high-throughput sequencing techniques (HTS). For this purpose we will create a database of main barcoding genes such as COI, 18S as well as ITS region for calanoid copepods and pelagic tunicates to serve as a reference for metabarcoding studies. The aim of our project is to use HTS for genetic characterization of Adriatic mesozooplankton populations, to determine differences in their genetic composition between different parts of the Adriatic which differ in their depth, magnitude of seasonal variation in salinity and temperature (such as North and South Adriatic) and distance from the shore and. Special attention will be paid to genetic characterization of deep sea populations and populations in enclosed coastal environments which are known to harbour distinct zooplankton, such as Mljet lakes. The project will gather comprehensive data on the state and interactions of Adriatic zooplankton communities which would serve as a basis for better environmental management. Furthermore, we will assess the potential of HTS as a monitoring technique for non-indigenous species, their dispersal and impact on zooplankton community. ]]></summary_en></project><project>
<id>10050</id><title_hr><![CDATA[Razvoj nove generacije snack proizvoda namijenjenih potrošačima s posebnim prehrambenim potrebama primjenom tehnologija 3D tiskanja]]></title_hr><title_en><![CDATA[Development of New Generation of Snack Food for Consumers with Specific Dietary Needs using 3D Printing Technologies]]></title_en><user_id>19368</user_id><user_firstLast_name>Dubravka Novotni</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2020-02</proposal_call><code>IP-2020-02-3829</code><acronim><![CDATA[3DSnack4Health]]></acronim><duration>15.02.2021 - 14.02.2025</duration><status>Završio</status><financ_value>140.613,18 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Prehrambena tehnologija, </scie_field_hr><scie_field_en>Food technology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Food Technology and Biotechnology]]></institution_en><team_members_id>7661, 19413, 19412, 29515, 6236, 19135, 13351, 865237, 26629, </team_members_id><team_members_names><![CDATA[Duška Ćurić, Nikolina Čukelj Mustač, Bojana Voučko, Ana Pilipović, Maja Benković, Saša Drakula, Filip Dujmić, Mislav Tujmer, Kristina Radoš, ]]></team_members_names><keywords_hr><![CDATA[aditivna tehnologija, dijetni snack na bazi žitarica, bez glutena, fermentabilni ugljikohidrati, reologija pasti, razvoj 3D pisača, profil arome]]></keywords_hr><keywords_en><![CDATA[additive technology, cereal based dietetic snack, gluten-free, fermentable carbohydrates, paste rheology, 3D printer development, aroma profile]]></keywords_en><summary_hr><![CDATA[U svijetu je sve veća pojavnost nezaraznih bolesti kao što diabetes mellitus, celijakija, osjetljivost na pšenicu (NCWS) i sindrom iritabilnog crijeva (IBS) kod kojih postoje ograničenja u konzumaciji hrane od žitarica zbog velikog sadržaja određenih ugljikohidrata i/ili glutena. Stoga se oboljeli trebaju držati cjeloživotne dijete, što je vrlo zahtjevno s obzirom na ograničeni asortiman, lošu kvalitetu i visoku cijenu hrane za posebne prehrambene potrebe. Zahvaljujući intenzivnom razvoju digitalnih tehnologija, osobito aditivne tehnologije (3D tiskanje), otvorile su se nove mogućnosti i izazovi u proizvodnji hrane. Za proizvodnju 3D tiskane hrane moguće je koristiti različite sirovine i njihove smjese pri čemu je potrebno voditi računa o njihovim kemijskim i fizikalnim svojstvima, odnosno sposobnosti tiskanja, kao i interakcijama pojedinih sastojaka pri kreiranju proizvoda uravnoteženog nutritivnog sastava. Cilj ovog projekta je istražiti mogućnost razvoja snack proizvoda na bazi žitarica primjenom 3D tiska namijenjenih potrošačima oboljelima od dijabetesa, celijakije, NCWS i IBS-a, optimiranog nutritivnog sastava, poželjnih fizikalnih i senzorskih svojstava.  Rezultati ovog projekta doprinijet će razumijevanju utjecaju procesa predobrade (fizikalni i biokemijski postupci) na reološka svojstva pasti sastavljenih od visokomolekularnih polisaharida, proteina i lipida, pogodnih za 3D tiskanje snack proizvoda i postizanje stabilne strukture. Osim toga, definirati će uvjeti procesa završne obrade proizvoda kojima će se osigurati mikrobiološka ispravnost i poželjna senzorska svojstva proizvoda visoke prehrambene vrijednosti. Predložit će se i konstruirati 3D pisač po mjeri, namijenjen izradi snack proizvoda za potrošače s navedenim posebnim prehrambenim potrebama. Rezultati će imati utjecaj na tehnološki razvoj, osobito prehrambene industrije, ali i na kvalitetu života osoba s posebnim prehrambenim potrebama.]]></summary_hr><summary_en><![CDATA[Globally, there is an increasing incidence of non-communicable diseases such as diabetes mellitus, celiac disease, non-coeliac wheat sensitivity (NCWS) and irritable bowel syndrome (IBS), in which the consumption of cereal foods is restricted due to the high content of specific carbohydrates and/or gluten. Keeping a lifelong diet is very demanding given the limited assortment, poor quality and high cost of food products in the market of food for specific dietary purposes. Due to the intensive development of digital technologies, especially additive technology (3D print), there are new opportunities and challenges in food production. For making 3D printed food products of balanced nutritional composition, it is possible to use different raw materials and their mixtures, considering their nutritive and physical properties, i.e. the printability, as well as the interactions of individual ingredients. The aim of this project is to explore the possibility of developing snack products based on cereals using 3D printing intended for consumers with diabetes, celiac disease, NCWS and IBS, of optimal nutritional composition, desirable physical and sensory properties. The results of this project will contribute to the understanding of the pre-processing (physical and biochemical) on the formation of pastes composed of high molecular weight polysaccharides, proteins and lipids, which are suitable for 3D printing of snack products and retaining the stable structure. In addition, post-processing conditions for 3D snack products will be defined with the aim of achieving microbiological safety and desirable sensory properties of highly nutritive products. Custom-made 3D printer for making food for consumers with specific dietary needs will be proposed and constructed. Our results will have an impact on technological development, especially in the food industry, but also on the quality of life of people with specific dietary needs.]]></summary_en></project><project>
<id>10052</id><title_hr><![CDATA[Ferocenski analozi biomolekula: strukturna karakterizacija i biološka evaluacija]]></title_hr><title_en><![CDATA[Ferrocene analogues of biomolecules: structural characterization and biological evaluation]]></title_en><user_id>300</user_id><user_firstLast_name>Lidija Barišić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2020-02</proposal_call><code>IP-2020-02-9162</code><acronim><![CDATA[FER-AN-BIOMOL]]></acronim><duration>11.01.2021 - 10.07.2025</duration><status>Završio</status><financ_value>197.770,26 eur</financ_value><scie_area_hr>Biotehničke znanosti, Prirodne znanosti, </scie_area_hr><scie_area_en>Biotechnical sciences, Natural sciences, </scie_area_en><scie_field_hr>Interdisciplinarne biotehničke znanosti, Kemija, Biotehnologija, Biotehnologija u biomedicini, Interdisciplinarne prirodne znanosti, </scie_field_hr><scie_field_en>Interdisciplinary biotechnical sciences, Chemistry, Biotechnology, Biotechnology in Biomedicine, Interdisciplinary natural sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Food Technology and Biotechnology]]></institution_en><team_members_id>1307, 23617, 2830, 3057, 22774, 5505, 5597, 5587, 11119, 484, 29236, 9862, 5425, </team_members_id><team_members_names><![CDATA[Damir Stanzer, Karla Hanousek Čiča, Ivana Kmetič, Teuta Murati, Marina Miletić, Veronika Kovač, Monika Kovačević, Mojca Čakić Semenčić, Marko Nuskol, Rosana Ribić, Marija Lovrić, Žiga  Jakopin , Dora Markulin, ]]></team_members_names><keywords_hr><![CDATA[biološka aktivnost, biomolekule, bioizosterija, ferocen,  muropeptidi, peptidi, peptidomimetici, polifenoli, SAR]]></keywords_hr><keywords_en><![CDATA[biological activity, biomolecules, bioisosterism, ferrocene, muropeptides, peptides, peptidomimetics, polyphenols, SAR ]]></keywords_en><summary_hr><![CDATA[Umetanje ferocenskog kalupa u okosnicu prirodnih peptida inducira tvorbu okreta i zauzimanje visokouređenih struktura. Okreti omogućuju nabiranje peptida nužno za biološku aktivnost te sudjeluju u molekulskom prepoznavanju. Osim kao začetnik okreta, ferocen se primjenjuje za bioizosternu modifikaciju penicilina, tamoksifena i drugih biološki aktivnih molekula. U sklopu ovog projekta bit će istražen potencijal ferocena u indukciji okreta u (muro)peptidima te bioizosternoj modifikaciji biomolekula (resveratrola i kurkumina). Kiralnost i lipofilnost od presudnog su značaja pri dizajnu i sintezi biološki aktivnih spojeva. Stoga ćemo pripraviti homo- i heterokiralne peptide građene iz ferocenskog kalupa i hidrofobnih aminokiselina kako bismo korelirali konformacijska svojstva i kiralnost peptidne okosnice. Pripravit ćemo i ferocenske analoge imunološki aktivnog muramil-dipeptida i istražiti njihova konformacijska svojstva. Biološka aktivnost pripravljenih biokonjugata bit će određena ispitivanjem njihovog antitumorskog, antimikrobnog i antioksidacijskog učinka, dok će ferocenskim analozima muramil-dipeptida biti određen i imunomodulacijski kapacitet. Testovima biološke aktivnosti bit će podvrgnuti i ferocenski analozi resveratrola i kurkumina, dizajnirani da osim ferocena sadrže lipofilnu estersku spojnicu i alkilnu razmaknicu ili heterocikličke bioizosterne skupine, prisutne u brojnim etabliranim lijekovima. Analiza odnosa kiralnosti i konformacije, strukture i konformacije, kiralnosti i aktivnosti te strukture i aktivnosti u pripravljenim biokonjugatima omogućit će izradu biblioteke ferocenskih (muro)peptida s precizno definiranim odnosom strukture i aktivnosti (SAR) i služit će kao smjernice za naša buduća istraživanja ferocenskih analoga biomolekula s unaprijeđenom biološkom aktivnošću te će ujedno činiti vrijedan doprinos propulzivnom području kemijske biotehnologije.]]></summary_hr><summary_en><![CDATA[Introduction of ferrocene scaffold into peptide backbone induces turn formation and adoption of highly organized structures. Turns enable protein folding required for biological activity and are also involved in molecular recognition. Besides the role of turn nucleator, ferrocene is also used for bioisosteric modification of penicillin, tamoxifen, etc. In this project, the potential of ferrocene both in nucleating of turn structures in ferrocene (muro)peptides and bioisosteric modification of biomolecules (resveratrol and curcumin) will be explored. Chirality and lipophilicity are of the crucial importance in design of biologically active molecules. Therefore, we will prepare homo- and heterochiral peptides composed of ferrocene and hydrophobic amino acids in order to correlate the conformation with chirality of the peptide backbone. We will synthesize ferrocene analogues of muramyl peptide and their conformational properties will be explored. The biological activity of the novel bioconjugates will be determined by testing of their antitumor, antimicrobial and antioxidative effects. In addition, ferrocene analogues of muramyl peptide will be subjected to evaluation of immunomodulatory effect. Ferrocene analogues of resveratrol and curcumin, designed to contain lipophilic ester and alkyl groups or heterocyclic bioisostere groups represented in numerous established drugs, will be subjected to biological evaluation too. The analysis of correlation of chirality and conformation, structure and conformation, chirality and activity as well as structure and activity will enable us not only to create SAR library of ferrocene (muro)peptides but also to make a valuable contribution to the propulsive field of chemical biotechnology.]]></summary_en></project><project>
<id>10053</id><title_hr><![CDATA[Razvoj modela za procjenu ponašanja materijala temeljenih na strojnom učenju]]></title_hr><title_en><![CDATA[Development of machine learning-based models for materials behavior estimation]]></title_en><user_id>12834</user_id><user_firstLast_name>Robert Basan</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2020-02</proposal_call><code>IP-2020-02-5764</code><acronim><![CDATA[MADEIRA]]></acronim><duration>15.12.2020 - 14.12.2024</duration><status>Završio</status><financ_value>132.457,36 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, Temeljne tehničke znanosti, </scie_field_hr><scie_field_en>Mechnical engineering, Basic engineering sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Tehnički fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Engineering]]></institution_en><team_members_id>12820, 1419, 7621, 26750, 865231, </team_members_id><team_members_names><![CDATA[Tea Marohnić, Dario Iljkić, Sunčana Smokvina Hanza, Andrej Žerovnik, Ela Marković, ]]></team_members_names><keywords_hr><![CDATA[ponašanje materijala, zamor materijala, toplinska obrada, strojno učenje, modeliranje materijala]]></keywords_hr><keywords_en><![CDATA[material behavior, fatigue of materials, heat treatment, machine learning, materials modelling]]></keywords_en><summary_hr><![CDATA[Modeliranje ponašanja materijala ključan je dio suvremenog razvoja proizvoda te računalnih simulacija koje se provode u cilju čim boljeg iskorištenja materijala i smanjenja mase i troškova. Za uspješno modeliranje ponašanja materijala nužno je poznavanje njegovih značajki i parametara ponašanja. Njihovo eksperimentalno određivanje je najtočnije, ali je dugotrajno i skupo te se stoga nastoji izvoditi u najmanjoj mogućoj mjeri. Projektom MADEIRA cilja se na rješavanje nedostatka podataka o ponašanju materijala potrebnih za numeričke proračune i simulacije koji otežava šire prihvaćanje modeliranja materijala te uključivanje naprednih materijalnih modela u suvremeni proces razvoja proizvoda. Predloženo istraživanje usmjereno je razvoju modela za procjenu ponašanja i parametara materijala temeljenih na strojnom učenju kao rješenja za navedene probleme. Na osnovi prikupljenih rezultata istraživanja materijala i rezultata provedenih eksperimenata, sustavno će se istražiti, identificirati i mapirati kompleksni odnosi između svojstava/značajki materijala i njegovog mehaničkog ponašanja i pripadnih parametara na različitim razinama. Unaprijedit će se postojeći i razviti novi modeli procjene naprednih monotonih, cikličkih i zamornih parametara materijala te matematički modeli termalnih postupaka prerade metala i modeliranja njihovih mehaničkih svojstava nakon toplinske obrade. Istražit će se primjenjivost raznih metoda strojnog učenja te mogućnosti procjene parametara i naprednih konstitutivnih materijalnih modela koji se zbog kompleksnosti i velikog broja potrebnih parametara otežano i rijetko primjenjuju u praksi. Razvijene baze podataka i prediktivni modeli trebali bi doprinijeti široj primjeni modeliranja ponašanja materijala i računalnih simulacija, a uspostavljen metodološki okvir i principi primjene strojnog učenja mogli bi biti korisni i primjenjivi za razvoj prediktivnih modela i u drugim područjima primjene i istraživanja materijala.]]></summary_hr><summary_en><![CDATA[Materials modeling is a key part of modern product development and computer simulations which are performed in order to improve material utilisation and reduce weight and costs. The main prerequisite for successful materials modeling is knowledge of its behavior and properties. Their experimental determination is the most accurate, but it is long-lasting and expensive, and there is a trend to perform as few experiments as possible. The MADEIRA project addresses the lack of material data and behavior parameters needed for numerical simulations which is one of the major obstacles to wider use of advanced material models in the industry. Proposed research aims at the development of advanced machine learning-based models for estimation of material behavior and related parameters as a solution for mentioned problems. Based on results of materials research and data collected from published sources and results of own experiments, complex relationships between properties and behavior of the materials will be systematically analyzed, identified and mapped at different levels. Existing models for estimation of advanced monotonic, cyclic and fatigue parameters will be improved and new ones developed. Mathematical models of thermal processes of metals and prediction of their mechanical properties after heat treatment will be further improved. The applicability of different machine learning-based methods for estimation of parameters of advanced constitutive material models will be investigated which, due to the large number of required material parameters, are rarely applied in industrial practice. Developed database and predictive models should contribute to the wider application of material behavior modeling and computer simulations, and the established methodological framework and principles of machine learning may be useful and applicable for the development of predictive models in other fields of material research and application.]]></summary_en></project><project>
<id>10055</id><title_hr><![CDATA[Dizajn, sinteza i računalna analiza novih optičkih kemijskih pH osjetilnih derivata benzazola]]></title_hr><title_en><![CDATA[Design, Synthesis and Computational Analysis of Novel Optical Chemical pH Sensing Benzazole Derivatives]]></title_en><user_id>227</user_id><user_firstLast_name>Robert Vianello</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2020-02</proposal_call><code>IP-2020-02-8090</code><acronim><![CDATA[BenzpHSens]]></acronim><duration>01.02.2021 - 20.06.2025</duration><status>Završio</status><financ_value>128.741,12 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>2914, 25735, 24248, 867203, 867578, 869853, </team_members_id><team_members_names><![CDATA[Marijana Hranjec, Ida Boček, Tana Tandarić, Marina Galić, Lucija Vrban, Antonija Mamić, ]]></team_members_names><keywords_hr><![CDATA[benzazoli, organska sinteza, spektroskopska karakterizacija, računalna kemija, pH senzori]]></keywords_hr><keywords_en><![CDATA[benzazoles, organic synthesis, spectroscopic characterization, computational chemistry, pH sensors ]]></keywords_en><summary_hr><![CDATA[Predloženi projekt okuplja interdisciplinarni tim znanstvenika s ciljem razvoja nekoliko klasa organskih fluorofora baziranih na benzazolnom kosturu te ispitivanja njihove prikladnosti kao naprednih sustava za čitav niz primjena u području funkcionalnih osjetilnih materijala za pH u različitim otopinama. Kroz sinergiju u sintetskim, spektroskopskim i računalnim tehnikama, usmjerit ćemo naša istraživanja na dizajn spojeva sa željenim analitičkim i kemijskim karakteristikama, koristeći njihova fluorescentna i individualna funkcionalna svojstva. Eksperimentalni dio istraživanja uključivat će tradicionalne strategije za sintezu različitih derivata benzimidazola, benzotiazola, imidazo[4,5-b]piridina i imino-kumarina, koji će biti okarakterizirani u otopini ovisno o promjenama u pH uvjetima. Sve faze eksperimentalnog rada nadopunit će se računalnom podrškom pri interpretaciji dobivenih rezultata, što će uključivati izračun konformacijskih, tautomernih i pKa svojstava proučavanih spojeva te modeliranje promjena u odgovarajućim elektronskim spektrima potaknutih kemijskim promjenama u okolini upotrebom čitavog niza kvantno-kemijskih izračuna i molekulsko dinamičkih simulacija. Pored toga, računalno modeliranje bit će prošireno i razmatranjem različito supstituiranih derivata priređenih spojeva, kako bi se fino podesila željena svojstva te tako pomoglo ciljanom odabiru budućih koraka u eksperimentalnim postupcima. Sveukupno gledano, predloženi projekt pozicionirat će okupljeni tim za značajne iskorake u području naprednih materijala uz izraženu mogućnost širokog raspona industrijskih aplikacija – od biomedicine do znanosti o okolišu. ]]></summary_hr><summary_en><![CDATA[This project brings together an interdisciplinary team of researchers with the aim to develop several classes of benzazole-based organic fluorophores, and evaluate their suitability as advanced materials for the sensing of pH in different solutions. Through a synergy in synthetic, spectroscopic and computational techniques, we plan to focus our investigations on designing molecules with desirable analytical and chemical features, utilizing their fluorescent and individual functional properties. Experimental work will involve traditional strategies for the synthesis of diverse benzimidazole, benzothiazole, imidazo[4,5-b]pyridine, and imino-coumarin derivatives, which will be characterized in solution relative to pH and environment modifications. All phases of the experimental work will be supported by computations to aid in the interpretation of results. These will include calculating the conformational, tautomeric and pKa properties, and modeling changes in the electronic spectra induced upon the chemical change in the environment employing a range of quantum-chemical calculations and molecular dynamics simulations. In addition, computational modeling will be extended by considering differently substituted derivatives of the prepared heterocycles in order to fine-tune the desired properties, thus helping in the guided selection of future experimental directions. Overall, the presented research is intended to pose the gathered team for the advancements in the field of advanced materials with the significant promise of a wide range of industrial applications – from biomedicine to environmental sciences.]]></summary_en></project><project>
<id>10058</id><title_hr><![CDATA[Funkcionalizirani dvodimenzionalni materijali]]></title_hr><title_en><![CDATA[Functionalized two-dimensional materials]]></title_en><user_id>5765</user_id><user_firstLast_name>Ida Delač Marion</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2020-02</proposal_call><code>UIP-2020-02-8891</code><acronim><![CDATA[Fun2DMat]]></acronim><duration>01.01.2021 - 30.06.2026</duration><status>U tijeku</status><financ_value>263.839,67 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut za fiziku]]></institution_hr><institution_en><![CDATA[Institute of Physics in Zagreb]]></institution_en><team_members_id>1069, 864971, 864970, 866820, 867382, 869886, </team_members_id><team_members_names><![CDATA[Atiđa Selmani, Šimun Mandić, Antun Lovro Brkić, Vigor Božičević, Cosme Gonzalez, Mihael Brezak, ]]></team_members_names><keywords_hr><![CDATA[2D materijali, grafen, dihalkogenidi prijelaznih metala, organske molekule, samouređivanje, funkcionalizacija, mikroskopija pretražnom probom]]></keywords_hr><keywords_en><![CDATA[2D materials, graphene, transition metal dichalcogenides (TMD), organic molecules, self-assembly, functionalization, scanning probe microscopy]]></keywords_en><summary_hr><![CDATA[Dvodimenzionalni (2D) materijali, atomski tanki slojevi različitih materijala, perspektivna su osnova za novu generaciju elektroničkih i drugih uređaja zbog svojih vrhunskih elektronskih, optičkih i mehaničkih svojstava. Prije njihove primjene u uređajima potrebno je riješiti niz problema oko prilagodbe njihovih svojstava. Samouređivanje organskih molekula na 2D materijalima je novo, brzo rastuće područje istraživanja fokusirano na dva cilja: prilagodba (opto)elektroničkih svojstava 2D materijala budući adsorpcija utječe na npr. dopiranje, međuvrpčani procjep, optički odziv te upotreba 2D materijala kao graničnog sloja s ciljem očuvanja molekularnih svojstava (npr. magnetskih ili katalitičkih) adsorbiranog molekularnog sloja. Cilj ovog projekta je uspostavljanje nove istraživačke grupe koja će proučavati utjecaj funkcionalizacije kovalentno ili nekovalentno vezanih organskih molekula na svojstva 2D materijala. Polazna točka istraživanja je ekspertiza Instituta za fiziku u Zagrebu (IFZg) u sintezi, transferu i karakterizaciji 2D materijala. Istraživački kapacitet je u tijeku značajne nadogradnje u sklopu dva nacionalno relevantna projekta: Centra izvrsnosti za napredne materijale i senzore (CEMS), čija je Istraživačka jedinica za znanost o grafenu i srodnim 2D strukturama (G2D), uglavnom aktivna na IFZg-u, i Centru za napredne laserske tehnike (CALT). Istraživanje planirano u okviru ovog prijedloga kompatibilno je s oba ova projekta, dok istovremeno uvodi novo i uzbudljivo područje istraživanja s raznovrsnim potencijalnim primjenama, u područjima kao što su (opto-)elektronika, senzori, membrane za odvajanje plinova ili pročišćavanje vode, fleksibilna elektronika itd.]]></summary_hr><summary_en><![CDATA[Two-dimensional (2D) materials are promising building blocks for the next-generation devices due to their superior electrical, optical, and mechanical properties. Important issues in control of their properties remain to be addressed before these materials can be implemented in commercial devices. Molecular self-assembly on 2D materials is a new, quickly developing research field that is focused on two goals:  modification of (opto)electronic properties of 2D materials since molecular adsorption influences e.g. doping, band gap or optical response and use of 2D materials as a decoupling layer in order to preserve properties (e.g.  magnetic or catalytic) of the adsorbed molecules. The objective of this project is to establish a new research group that will study influence of functionalization with covalently or non-covalently bound organic molecules on 2D materials’ properties. Starting point is the expertise at the Institute of Physics, Zagreb (IFZg) in synthesis, transfer and characterization of 2D materials. This research capacity is ongoing a significant upgrade, through the activities of two nationally relevant projects: Center of Excellence for Advanced Materials and Sensing Devices (CEMS), whose research unit for science of Graphene and Related 2D Structures (G2D) is mainly active at the IFZg, and Centre for Advanced Laser Techniques (CALT). Research planned within this proposal is compatible with both these projects while simultaneously introduces new and exciting field with potential for various applications including (opto-)electronics, sensors, membranes for gas separation or water purification, flexible electronics, etc.]]></summary_en></project><project>
<id>10059</id><title_hr><![CDATA[Rituali, ceremonije i simboli hrvatskog srednjovjekovlja u europskom kontekstu (800-1600)]]></title_hr><title_en><![CDATA[Rituals, Ceremonies and Symbols of the Croatian Middle Ages in the European Context (800-1600)]]></title_en><user_id>4169</user_id><user_firstLast_name>Robert Kurelic</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2020-02</proposal_call><code>IP-2020-02-3702</code><acronim><![CDATA[ReCogniSeMe]]></acronim><duration>01.01.2021 - 31.12.2024</duration><status>Završio</status><financ_value>91.760,88 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Povijest, Povijest umjetnosti, </scie_field_hr><scie_field_en>History, Art history, </scie_field_en><institution_hr><![CDATA[Sveučilište Jurja Dobrile u Puli]]></institution_hr><institution_en><![CDATA[Juraj Dobrila University of Pula]]></institution_en><team_members_id>5605, 4714, 4310, 3742, 28926, 866898, </team_members_id><team_members_names><![CDATA[Ivan Jurković, Maurizio Levak, Violeta Moretti, Ivana Prijatelj Pavičić, Josip Banić, Davor Salihović, ]]></team_members_names><keywords_hr><![CDATA[simboli, ceremonije, rituali, reprezentacija, komunikacija, srednjovjekovne elite]]></keywords_hr><keywords_en><![CDATA[symbols, ceremonies, rituals, representation, communication, medieval elites]]></keywords_en><summary_hr><![CDATA[Projekt se bavi analizom i interpretacijom simboličke komunikacije u hrvatskim zemljama i njihovom susjedstvu u srednjem vijeku. Simbolička komunikacija manifestira se putem materijalnih i nematerijalnih znakova i simbola – i danas važnih u svakodnevnom životu – te verbalnih i neverbalnih signala i rituala, ključnih čimbenika za određivanje i obranu društvenog položaja i hijerarhije. Srednjovjekovne i ranonovovjekovne elite koristile su simboličku komunikaciju: pečate, grbove, reprezentativnu arhitekturu, umjetnost, viteštvo i dr., kako bi legitimirale i obranile svoju vlast i status. Nadalje, upotrebljavale su i kompleksni sustav rituala kao znak objave rata ili savezništva, sklapanje mira, socijalnu mobilnost i dr. Riječ je, dakle, o dimenziji djelovanja koju možemo smatrati ključnom za razumijevanje ponašanja društvenih elita u srednjem i početkom novog vijeka. U sklopu projekta će se simbolička komunikacija sagledat s više različitih aspekata. Proučavat će se načini na koji su hrvatske elite koristile simbole, ceremonije i rituale u svom društvenom i političkom životu, u kojoj mjeri je riječ o „uvezenim“ konvencijama i obrascima iz kulturno dominantnih država u susjedstvu, te koliko može biti govora o domaćim inovacijama ili hibridnim modelima. Kako su znakovi i simboli često sadržavaju naglašenu vizualnu komponentu, njihovo razumijevanje svakako uključuje i umjetničku dimenziju, pa je važno problemu pristupiti i interdisciplinarno. U ovom slučaju radi se o povijesti umjetnosti koja tradicionalnoj povijesti pomaže u interpretaciji kompleksnih spona međuovisnosti srednjovjekovnih i novovjekovnih elita i njihovih dinastičkih i društveno-političkih mreža. Za razumijevanje hrvatske povijesti nužno je također sagledati i susjedne zemlje, tako da će se razmatrati i situacija u Bosni, Italiji, Ugarskoj, jugoistoku Svetog Rimskog Carstva i drugim zemljama čije su elite bile rodbinski ili politički povezane s hrvatskim prostorima.]]></summary_hr><summary_en><![CDATA[The project analyses and interprets symbolic communication in Croatian territories and the neighbouring regions in medieval times. Symbolic communication manifests through material and immaterial signs and symbols – important even today in everyday life – as well as verbal and nonverbal signals and rituals, key factors for determining and defending one’s social status and the hierarchy. Medieval and early modern elites used symbolic communication: seals, coats of arms, representative architecture, art, chivalry and so on, in order to legitimise their power and status. Moreover, they used a complex system of rituals to declare war, alliances, peace or social mobility. It is a key dimension to understand the behaviour of social elites in medieval and early modern times. The project will look at symbolic communication from several aspects. We will study the way Croatian elites used symbols, ceremonies and rituals in their social and political lives, whether they were “imported” conventions and patterns from culturally dominant neighbours, locally made or mixed. Since symbols tend to contain a strong visual component, their understanding naturally includes an artistic viewpoint. It is, therefore, important to have an interdisciplinary approach. In this case history of art will be used to help traditional history in understanding  the complex web of interdependencies between medieval and early modern elites and their dynastic networks. To understand Croatian history it is vital to consider the neighbouring regions such as Bosnia, Italy, Hungary, the southeast of the Holy Roman Empire and other realms whose elites nurtured familial and political ties with Croatian lands.]]></summary_en></project><project>
<id>10060</id><title_hr><![CDATA[2D materijali bazirani na boru]]></title_hr><title_en><![CDATA[Boron-based 2D materials]]></title_en><user_id>5785</user_id><user_firstLast_name>Marin Petrović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2020-02</proposal_call><code>UIP-2020-02-1732</code><acronim><![CDATA[BoBaMat]]></acronim><duration>01.01.2021 - 30.06.2026</duration><status>U tijeku</status><financ_value>264.954,54 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut za fiziku]]></institution_hr><institution_en><![CDATA[Institute of Physics in Zagreb]]></institution_en><team_members_id>26532, 866637, 866641, </team_members_id><team_members_names><![CDATA[Borna Radatović, Patrick Seleš, Sherif Kamal, ]]></team_members_names><keywords_hr><![CDATA[2D materijali, borov nitrid, BCN legura, borofen, slojevite heterostrkture, CVD sinteza, nanostrukture]]></keywords_hr><keywords_en><![CDATA[2D materials, boron nitride, BCN alloy, borophene, layered heterostructures, CVD synthesis, nanostructures]]></keywords_en><summary_hr><![CDATA[Sinteza dvodimenzionalnih (2D) materijala i njihova integracija u složenije sisteme su trenutno veoma aktivna područja istraživanja u znanosti. Slaganjem visoko-kvalitetnih 2D materijala u kompleksnije heterostrukture mogu se dobiti novi sistemi naprednih funkcionalnosti, koji su često zanimljivi za različite primjene u tehnologiji. U ovom projektu fokus je stavljen na istraživanje 2D materijala baziranih na boru: heksagonalnog borovog nitrida (izolator), BCN legure (poluvodič) i borofena (metal). Ciljevi projekta su optimizacija sinteze tih materijala na jeftinim i lako dostupnim podlogama, razvoj procedura za njihov transfer na proizvoljne podloge te karakterizacija odgovarajućih vertikalnih heterostruktura. Naglasak je stavljen na postizanje odnosno očuvanje visoke strukturne kvalitete 2D materijala u svim segmentima istraživanja, što je ključno ukoliko se žele zadržati njihova intrinzična svojstva. Dodatno, projekt će omogućiti konstrukciju i karakterizaciju nekoliko prototipskih uređaja sastavljenih od 2D materijala baziranih na boru, čime će se ispitati njihov tehnološki potencijal. 2D materijali će se sintetizirati na metalnim podlogama metodom kemijske depozicije para unutar ultra-visoko vakuumske komore koja će se nabaviti u sklopu projekta. Dizajn komore će omogućiti dobivanje nekoliko uzoraka dnevno, čime će se osigurati pouzdan izvor visoko-kvalitetnih 2D materijala neophodan za njihovo temeljito istraživanje sa svih aspekata, od sinteze pa sve do primjena. Inicijalna provjera kvalitete 2D materijala će se vršiti pomoću elektronske difrakcije, dok će se daljnja strukturna analiza i karakterizacija elektronske strukture vršiti mikroskopijama pretražnom probom, pretražnom elektronskom mikroskopijom te fotoelektronskom spektroskopijom.]]></summary_hr><summary_en><![CDATA[Synthesis of two-dimensional (2D) materials and their integration into more complex systems are currently very active fields of scientific research. By stacking high-quality 2D materials into complex heterostructures, it is possible to obtain new systems with improved functionalities, which are often interesting for various applications in technology. The focus of this project is on research of boron-based 2D materials: hexagonal boron nitride (an insulator), BCN alloy (a semiconductor) and borophene (a metal). Goals of the project are synthesis optimization of those materials on low-cost and readily available substrates, development of procedures for their transfer onto arbitrary substrates, and characterization of the corresponding vertical heterostructures. The emphasis is put on achieving and maintaining of high structural quality of 2D materials in all segments of research, which is crucial if one wants to keep their intrinsic properties. In addition, the project will enable construction and characterization of several prototypical devices composed of boron-based 2D materials, allowing for the investigation of their technological potential. 2D materials will be synthesized on metal substrates by utilizing chemical vapor deposition in an ultra-high vacuum chamber that will be acquired within the project. The design of the chamber will allow synthesis of several samples per day, which will ensure a reliable source of high-quality 2D materials indispensable for their thorough research from all aspects, from synthesis and all the way to applications. The initial quality check of 2D materials shall be performed by means of electron diffraction, and further structural analysis and characterization of the electronic structure will be carried out by scanning probe microscopies, scanning electron microscopy and photoelectron spectroscopy.]]></summary_en></project><project>
<id>10061</id><title_hr><![CDATA[Biomimetički “funnel” i “bowl” supramolekularni sustavi za selektivno prepoznavanje DNA/RNA]]></title_hr><title_en><![CDATA[Biomimetic “funnel” and “bowl” supramolecular systems for the selective recognition of DNA/RNA]]></title_en><user_id>2648</user_id><user_firstLast_name>Aleksandar Višnjevac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2020-02</proposal_call><code>IP-2020-02-3786</code><acronim><![CDATA[CALIXDNA / CALIXDNA]]></acronim><duration>01.02.2021 - 31.01.2025</duration><status>U tijeku</status><financ_value>196.827,92 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, Interdisciplinarne prirodne znanosti, </scie_field_hr><scie_field_en>Chemistry, Interdisciplinary natural sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>28966, 28964, 480, 3300, 21411, </team_members_id><team_members_names><![CDATA[Benoit Colasson, Olivia Reinaud, Ivo Piantanida, Biserka Kojić-Prodić, Ivana Nikšić-Franjić, ]]></team_members_names><keywords_hr><![CDATA[kaliksareni, rezorcinareni, biomimetičko prepoznavanje, DNA, RNA, makromolekularna kristalografija]]></keywords_hr><keywords_en><![CDATA[calixarenes, resorcinarenes, biomimetic recognition, DNA, RNA, macromolecular crystallography]]></keywords_en><summary_hr><![CDATA[Razvoj novih molekularnih sustava koji bi mogli prepoznati specifične sekvence nukleinskih kiselina je predmet iznimnog istraživačkog interesa, s ciljem razvoja novih lijekova, biosenzora ili alata za osnovne biokemijske i biološke studije. Za razliku od proteina koji prepoznaju dvolančanu DNA kroz interakciju s velikim utorom, male molekule se obično interkaliraju ili odabiru mali utor za interakciju, ostavljajući tako prepoznavanje velikog utora od strane malih molekula praktički neistraženim područjem. Stoga mi ovdje predlažemo ispitivanje interakcije nukleinskih kiselina s makrocikličkim strukturama temeljenim na derivatiziranim kaliks[6]arenima [konformacijski fleksibilni, ljevčasti (funnel) sustavi] i rezorcinarenima [krutiji, zdjelasti (bowl) sustavi], koji su dimenzijama, oblikom i opremljenošću funkcionalnim skupinama pogodni za biomimetičko prepoznavanje nukleinskih kiselina na način kako to rade proteini. Istraživanje će se provoditi interaktivno i započet će s (već optimiziranom) sintezom i kemijskom/strukturnom karakterizacijom početnog skupa od 16 „funnel“ i „bowl“ potencijalnih DNA/RNA vezivača, nakon čega će uslijediti ispitivanja prepoznavanja i vezivanja na odabrani skup poli- i oligonukleotida, biološki testovi i rendgenska strukturna analiza njihovih kompleksa s oligonukleotidima. Na temelju rezultata prve iteracije, najbolji vezivači će biti derivatizirani fluorofornim aminokiselinama kako bi se poboljšala sposobnost i specifičnost prepoznavanja, te olakšalo spektroskopsko praćenje vezivanja. Skup analiza (prepoznavanje/vezanje, biološki testovi i strukturna analiza) primijenit će se na fluoroforne derivate. Na temelju tih rezultata, dizajnirat će se, sintetizirati i istražiti konačni skup obećavajućih biološki aktivnih vezivača sposobnih za selektivno prepoznavanje strukturnih elemenata u lancima nukleinskih kiselina, a time i s jasnim i neposrednim aplikativnim potencijalom u dizajnu lijekova i istraživanju biosenzora.]]></summary_hr><summary_en><![CDATA[The development of new molecular systems able to recognize specific sequences in nucleic acids is a subject of uttermost importance for the development of new drugs, biosensors or tools for basic biochemical and biological studies. Unlike proteins which recognize ds-DNA through the interaction with its major grove, small molecular binders usually undergo intercalation or choose minor groove to interact, leaving the study of the major groove recognition by small molecular systems practically unexplored so far. We propose a study of the interaction of nucleic acids with macrocyclic structures based on derivatized calix[6]arenes (conformationally flexible “funnel” systems) and resorcinarenes (more rigid “bowl” systems), featuring a required size, shape and functionalities to mimic the way proteins recognize nucleic acids. The research will be conducted in an iterative fashion and start with a (already optimized) synthesis and chemical/structural characterization of the initial set of 16 funnel and bowl potential DNA/RNA binders, followed by their recognition and binding studies on the chosen set of poly- and oligonucleotides, biological tests and X-ray structure analysis of their complexes with oligonucleotides. Based on the results from the first iteration, fluorophoric amino acids will be grafted to the best binders from the initial set in order to further enhance their binding capacity, specificity and to facilitate spectroscopic monitoring of the recognition process. Complete set of analyses (recognition/binding, biological and structural) will be applied to the fluorophoric derivatives. Based on the results from this, second, iteration, a final set will be designed, synthesized and explored, to come up, at the end, with a set of promising biologically active binders capable of selective recognition of structural elements within the nucleic acid chains, and hence with the clear and imminent applicative potential in drug design and biosensor research.]]></summary_en></project><project>
<id>10067</id><title_hr><![CDATA[Imunoregulatorna uloga proteina PrPC u imunološkom antivirusnom odgovoru i otpornosti na citomegalovirusnu infekciju]]></title_hr><title_en><![CDATA[The immunoregulatory role of PrPC in antiviral immune response following cytomegaloviral infection]]></title_en><user_id>4941</user_id><user_firstLast_name>Tihana Lenac Roviš</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2020-02</proposal_call><code>IP-2020-02-6617</code><acronim><![CDATA[PrImReg]]></acronim><duration>01.04.2021 - 31.03.2025</duration><status>Završio</status><financ_value>194.742,85 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Medicine]]></institution_en><team_members_id>5204, 25629, 5361, 28660, 19184, 5357, 869615, </team_members_id><team_members_names><![CDATA[Paola Kučan Brlić, Milena Hasan, Hrvoje Šimić, Dubravka Karner, Maja Cokarić Brdovčak, Daria Kveštak, Ema Bellulovich, ]]></team_members_names><keywords_hr><![CDATA[infekcija, citomegalovirus, prion, prp, prpc, mozak, upala]]></keywords_hr><keywords_en><![CDATA[infection, cytomegalovirus, prion, prp, prpc, brain, inflammation]]></keywords_en><summary_hr><![CDATA[PrPC (cellular prion protein) je glikoprotein čija ključna uloga do danas nije utvrđena. Radi se o stresom-induciranoj molekuli i višeslojnom modulatoru imunih stanica, a studije potvrđuju ulogu PrPC u infekciji. Međutim, većinom je ispitivan utjecaj PrPC na puteve stanične smrti, dok je njegova uloga u imunološkom odgovoru zanemarena. S obzirom na dominantnu ispoljenost PrPC u mozgu, dekodiranje mreže medijatora imunološkog odgovora pod njegovim utjecajem moglo bi iznjedriti nove intervencije za smanjenje upale i oštećenja mozga. Tijekom prirođene infekcije humani citomegalovirus (HCMV) može doprijeti do mozga. Radi se o vodećem virusnom uzročniku neuroloških oštećenja u djece, većinom izazvanih samim upalnim odgovorom. Uloga proteina PrPC u HCMV-infekciji nije istraživana. Preliminarni rezultati na našem modelu prirođene CMV-infekcije upućuju da mišji CMV (MCMV) modulira ispoljavanje PrPC, osobito indukciju na mikrogliji. Za te rezidentne imune stanice mozga znamo kako su ključan faktor u neuropatologiji izazvanoj CMV-om. Ciljevi projekta su odrediti: 1) Ulogu proteina PrPC u upali i oštećenju mozga uslijed prirođene CMV-infekcije, 2) Mehanizam CMV-posredovane regulacije proteina PrPC u inficiranim stanicama te 3) Kako postojeći farmakološki pripravci koji djeluju na PrPC utječu na ishod neuroloških oštećenja izazvanih prirođenom infekcijom CMV-om. Konačno, očekujemo kako će projekt rezultirati 4) Povećanjem atraktivnosti za nove suradnje i ulaganja.Aktivnosti će provoditi Sveučilište u Rijeci, Medicinski fakultet uz potporu suradnice s Institut Pasteur u Parizu. Podloga projekta je stručnost tima u području: biologije proteina PrPC, patologije virusa CMV, imuno-fenotipiziranja stanica, &#39;single cell&#39; i slikovne dijagnostike stanica. Rezultati nemaju samo izgled informirati o patogenu CMV, proteinu PrPC i njihovoj interakciji, već o mnogo širem pojmu neuroinflamacije. Ponudit ćemo nova rješenja u području neuroimunološke aktivacije i posljedičnih oštećenja mozga.]]></summary_hr><summary_en><![CDATA[PrPC (prion protein cellular) is a glycoprotein whose key role has not been established to date. Studies have consistently supported the role of PrPC in infection, including infection with neurotropic viruses. However, its neuroprotective capacity was mainly investigated in the context of cell death pathways, while its role in immune response has largely been overlooked. Considering that PrPC is dominantly expressed in the brain, decoding the network of immune response mediators affected by PrPC might lead to the development of new interventions for reducing brain inflammation and pathology.During congenital infection, human cytomegalovirus (HCMV) can reach the brain, which makes it a leading viral cause of neurological disabilities in children, most likely caused by inflammation. The role of PrPC in HCMV infection has not been investigated. Preliminary results in our model of congenital CMV infection indicate that this virus modulates the expression of PrPC. Notably, PrPC was highly induced on microglia, CNS-resident immune cells involved in the inflammation-induced pathology.This project aims to determine: 1) the role of PrPC in inflammation and brain injury induced by congenital CMV infection, 2) mechanism of CMV-mediated PrPC regulation and 3) how pharmacological targeting of PrPC, or its downstream pathways, affects the observed neuropathology.Project activities will be carried out at the University of Rijeka, Faculty of Medicine, Croatia, with the support of an associate from the Institut Pasteur, Paris, France. The proposal builds on the applicants’ expertise in PrPC biology, CMV pathology, immunophenotyping, single cell analyses and imaging and has the potential to inform not only about the relationship between the CMV infection and the PrPC protein-induced processes, but more broadly about neuroinflammation. Also, we aim to offer new solutions to control immune reactivity in the brain and reduce the tissue injury.]]></summary_en></project><project>
<id>10069</id><title_hr><![CDATA[Istraživanje provenijencije umjetnina u zagrebačkim zbirkama]]></title_hr><title_en><![CDATA[ Provenance Research on Artwork in Zagreb Collections ]]></title_en><user_id>402</user_id><user_firstLast_name>Ljerka Dulibić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2020-02</proposal_call><code>IP-2020-02-1356</code><acronim><![CDATA[ZagArtColl_ProResear]]></acronim><duration>01.01.2021 - 31.12.2024</duration><status>Završio</status><financ_value>93.357,56 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Povijest umjetnosti, </scie_field_hr><scie_field_en>Art history, </scie_field_en><institution_hr><![CDATA[Hrvatska akademija znanosti i umjetnosti]]></institution_hr><institution_en><![CDATA[Croatian Academy of Sciences and Arts]]></institution_en><team_members_id>1515, 762, 29509, 25208, 29718, 29650, 865338, 24094, 870244, </team_members_id><team_members_names><![CDATA[Iva Pasini Tržec, Tanja Trška, Ivan Ferenčak, Bartol Fabijanić, Petra Vugrinec, Lucija Burić, Josip Klaić, Saša Vejzagić, Ana Petković Basletić, ]]></team_members_names><keywords_hr><![CDATA[umjetničke zbirke, Zagreb, provenijencija, Strossmayerova galerija starih majstora, transferi (vlasništva) umjetnina]]></keywords_hr><keywords_en><![CDATA[art collections, Zagreb, provenance research, Strossmayer Gallery of Old Masters, (ownership) transfers of artworks]]></keywords_en><summary_hr><![CDATA[U okviru predloženog projekta „Istraživanje provenijencije umjetnina u zagrebačkim zbirkama“ provest ćemo temeljito arhivsko istraživanje koje će biti čvrsto uporište za identifikaciju umjetnina i/ili zbirki u Zagrebu i praćenje njihove sudbine u slijedu promjena geopolitičkih okolnosti u različitim razdobljima hrvatske povijesti, posebice prije, tijekom i nakon II. svjetskog rata. Time će se omogućiti sagledavanje uloge različitih vlasti, institucija i pojedinaca u upravljanju umjetničkom baštinom. Umjetnine identificirane i/ili kontekstualizirane s aspekta provenijencije obradit će se i u okviru tradicionalnih povijesnoumjetničkih metoda, čime će se osigurati cjelovitost pristupa temi.Iako je Republika Hrvatska potpisnica međudržavnih dokumenata kojima se poziva na intenziviranje istraživanja podrijetla umjetnina, u Hrvatskoj istraživanje provenijencije još uvijek nije institucionalno podržano, a općenita svijest o potrebi utvrđivanja ranijih vlasnika umjetnina nije dovoljno razvijena niti u muzejima.Istraživanje sudbine umjetnina prije i tijekom poslijeratne muzealizacije izazovan je no nužan element u obuhvatnoj znanstvenoj i stručnoj obradi nacionalne nam kulturne baštine. Očekujemo značajan utjecaj na bolje razumijevanje uloge kulturne baštine u procesima društvenoga razvoja obilježenima (ne)razriješenim povijesnim konfliktima. Očekivani doprinos je i etabliranje različitih aspekata suvremene metodologije istraživanja provenijencije umjetnina u hrvatskoj povijesti umjetnosti.Transparentnost istraživačkih postupaka, čvrsto utemeljenih u arhivskim dokumentima i materijalnim tragovima vlasništva na umjetninama, osigurat će prijenos iskustava i metodologije ne samo povjesničarima umjetnosti već i muzejskim, arhivskim i djelatnicima srodnih struka, čime će se osigurati znatan utjecaj na etabliranje odgovornog i pouzdanog bavljenja ovom neistraženom i još uvijek &#39;osjetljivom&#39; temom u hrvatskim baštinskim ustanovama. ]]></summary_hr><summary_en><![CDATA[Within the project proposal Provenance Research on Artwork in Zagreb Collections, we will conduct an in-depth archival research which will provide a firm basis for identification of artworks and/or collections in Zagreb, as well as for tracking their destinies through a series of changes of geopolitical circumstances in different stages of Croatian history, especially before, during and after WWII. This will enable the assessment of the role of different regimes, institutions and individuals in management of artistic heritage. Artwork identified and/or contextualized from the aspect of their provenance will also be researched through the traditional art-historical methods, thus ensuring a comprehensive approach to the topic.Despite the fact that the Republic of Croatia is among the signatories of international agreements which encourage the intensification of provenance research, this type of research in Croatia is still lacking institutional support, and general awareness of the necessity of determining previous owners of artwork has not yet been sufficiently raised not even within the museum profession.The research of provenance of artwork before and after the post-war musealization is a challenging, but necessary element of comprehensive research of national cultural heritage. We anticipate a significant impact on understanding the role of cultural heritage in societal processes marked by (un)resolved historical conflicts. Expected impact of the research is also the introduction of contemporary methodology of provenance research into Croatian art history.The transparency of research, firmly grounded in the archival sources and material traces of ownership of artwork, will ensure the transfer of experiences and methodology not only to art historians, but also to other professionals, which will have a significant impact on establishing responsible and reliable engagement in this understudied and still “sensitive” topic in Croatian heritage institutions.]]></summary_en></project><project>
<id>10072</id><title_hr><![CDATA[Metodologija za procjenu parametara u problemima propagacije pukotina nastalih pod utjecajem ekstremnih mehaničkih opterećenja]]></title_hr><title_en><![CDATA[Parameter estimation framework for fracture propagation problems under extreme mechanical loads]]></title_en><user_id>13219</user_id><user_firstLast_name>Mijo Nikolić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2020-02</proposal_call><code>UIP-2020-02-6693</code><acronim><![CDATA[FracID]]></acronim><duration>01.02.2021 - 31.01.2026</duration><status>U tijeku</status><financ_value>207.333,60 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Građevinarstvo, Temeljne tehničke znanosti, Interdisciplinarne tehničke znanosti, </scie_field_hr><scie_field_en>Civil engineering, Basic engineering sciences, Interdisciplinary technological sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu Fakultet građevinarstva, arhitekture i geodezije]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Civil Engineering, Architecture and Geodesy]]></institution_en><team_members_id>29695, 3044, 865207, 25469, 22591, 869637, </team_members_id><team_members_names><![CDATA[Andjelka Stanić, Eduard Marenić, Matej Šodan, Jadran Čarija, Simona Dobrilla, Duje Pavić, ]]></team_members_names><keywords_hr><![CDATA[mehanika loma, model propagacije pukotina, stohastički inverzni problem, procjena parametara loma, nepouzdanosti parametara, slom konstrukcija]]></keywords_hr><keywords_en><![CDATA[fracture mechanics, fracture propagation model, stochastic inverse problem, fracture parameter estimation, parameter uncertainties, failure events]]></keywords_en><summary_hr><![CDATA[Pouzdano predviđanje i sprječavanje katastrofalnih događaja sloma u konstrukcijama i materijalima predstavlja složen inženjerski i znanstveni izazov. Čak i kada se koriste sofisticirani nelinearni numerički modeli koji mogu simulirati mehanizme sloma izazvane iniciranjem i propagacijom pukotina, rezultati se ne mogu smatrati pouzdanima ako su materijalni parametri nesigurni. Na predviđanje ponašanja i kapaciteta nosivosti konstrukcije osobito utječe nesigurnost parametara nakon dostizanja vršnih naprezanja. Predloženi projektni prijedlog ima za cilj razviti metodologiju za pouzdanu procjenu parametara loma. Metodologija će se temeljiti na rješenju stohastičkog inverznog problema koji kombinira mjerenja i računalni model. U ovom projektu koristit će se sintetička mjerenja. Računalni model će integrirati teoriju vjerojatnosti s Bayes-ovim teoremom i novim numeričkim modelom loma. Parametri loma ovise o nepoznatoj mikrostrukturi materijala s njegovim nedostacima i nesavršenostima, što ih čini nesigurnima. Početno znanje o nesigurnim parametrima bit će predstavljeno prethodnim probabilističkim distribucijama koje će se ažurirati u posteriorne distribucije pomoću mjerenja, teorije vjerojatnosti i modela loma. Novi numerički model loma će se razviti temeljem prethodnih istraživanja i ugrađenih jakih diskontinuiteta za simulaciju lokaliziranog sloma s novinama u određivanju elastičnih parametara rešetkastih elemenata koji modeliraju mikrostrukturu materijala. Metode Monte Carlo Markovljev lanac i Kalman filter implementirat će se i koristiti za procjenu parametara loma čelika i betona izloženih ekstremnim opterećenjima. Metodologija će također moći kvantificirati nesigurnosti koje proizlaze iz mikrostrukture što će rezultirati dubljim razumijevanjem fizikalnih procesa. Pouzdana procjena materijanih parametara loma unaprijedit će strategije predviđanja ponašanja konstrukcija, kako u projektiranju novih, tako i u ocjeni stanja i kapaciteta nosivosti postojećih.]]></summary_hr><summary_en><![CDATA[Correct prediction and prevention of catastrophic failure events in engineering structures and materials represent complex engineering and scientific challenge. Even when using sophisticated nonlinear numerical models that can simulate failure mechanisms induced by fracture initiation and propagation, outputs cannot be considered reliable if the material parameters are uncertain. The project proposal aims to develop a methodology for the reliable estimation of fracture parameters. The methodology will be based on a solution of stochastic inverse problem that combines measurements and a computational model. In this project we will use so-called synthetic measurements that serve for the methodology development, while our research group will develop the framework based on the probability theory with Bayesian inference and novel numerical fracture model. Fracture parameters depend on unknown microstructural composition of the material with its defects and imperfections, which makes them uncertain. Initial knowledge about uncertain parameters will be represented with prior probability distributions that will be updated to posterior distributions by using measurements, probability theory and the fracture model. The novel lattice numerical fracture model will be developed based on our previous research and embedded strong discontinuities for localized failure with the novelty related to computation of lattice elastic parameters. Monte Carlo Markov Chain and Kalman filter methods will be implemented and used in estimating fracture parameters of steel and concrete subjected to extreme loads. The methodology will also be able to quantify uncertainties that arise from microstructure resulting with deeper understanding of the physical problem and better decision making strategies. Reliable estimation of fracture parameters will enhance our predictive modelling strategies either when designing new structures or estimating the integrity and carrying capacity of existing.]]></summary_en></project><project>
<id>10076</id><title_hr><![CDATA[Tehnološke značajke i kulturne prakse u prapovijesnim lončarskim tradicijama na području Hrvatske ]]></title_hr><title_en><![CDATA[Technological features and cultural practices in prehistoric pottery traditions on the territory of Croatia]]></title_en><user_id>25791</user_id><user_firstLast_name>Andreja  Kudelić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2020-02</proposal_call><code>UIP-2020-02-3637</code><acronim><![CDATA[prePOT]]></acronim><duration>01.02.2021 - 31.07.2026</duration><status>U tijeku</status><financ_value>186.807,35 eur</financ_value><scie_area_hr>Humanističke znanosti, Prirodne znanosti, Interdiciplinarne znanosti, Društvene znanosti, Biomedicina i zdravstvo, </scie_area_hr><scie_area_en>Humanities, Natural sciences, Interdisciplinary scientific area, Social sciences, Biomedicine and health sciences, </scie_area_en><scie_field_hr>Arheologija, Geologija, Etnologija i antropologija, Interdisciplinarne prirodne znanosti, Interdisciplinarne humanističke znanosti, </scie_field_hr><scie_field_en>Archeology, Geology, Ethnology and anthropology, Interdisciplinary natural sciences, Interdisciplinary humanities, </scie_field_en><institution_hr><![CDATA[Institut za arheologiju]]></institution_hr><institution_en><![CDATA[Institute of Archaeology in Zagreb]]></institution_en><team_members_id>26249, 5547, 29684, 865169, 867223, 22536, </team_members_id><team_members_names><![CDATA[Dinko Tresić Pavičić, Ana Maričić, Mia Marijan, Natali Neral, Dalibor Branković Branković, Filomena Sirovica, ]]></team_members_names><keywords_hr><![CDATA[prapovijest, brončano doba,  arheometrija keramike, lončarska tehnologija, proizvodnja, distribucija, uporaba, tradicija]]></keywords_hr><keywords_en><![CDATA[prehistory, bronze age, archeometry of ceramics, pottery technology, production, distribution, use, tradition]]></keywords_en><summary_hr><![CDATA[Cilj projekta je uspostaviti istraživačku grupu mladih znanstvenika iz različitih područja znanosti (arheologija i geologija) i usmjeriti je u sustavno istraživanje lončarskih tradicija brončanog doba na području Hrvatske. Studija se planira provesti na širokom području, posebice na onim područjima koja su najslabije istražena, ali ključna kada je riječ o kulturnim utjecajima, komunikacijskim pravcima i praksi razmjene tehnologija i znanja između istočno-jadranskog prostora i njegovog zaleđa s južnim dijelom Panonske nizine. Istraživanja su stoga raspoređena na nekoliko istraživačkih područja: središnja Hrvatska, Lika i Gorski kotar, Istra i sjeverni Jadran, sjeverna i srednja Dalmacija i istočna Hrvatska. Lončarske tehnologije, funkcija i uporaba keramičkih posuda te kulturne prakse u prapovijesnim lončarskim tradicijama predstavljaju do sada netaknuto polje istraživanja na ovim područjima što omogućava potpuno novi pristup proučavanju prapovijesnih kulturnih grupa. U skladu s takvim pristupom u analitičkom fokusu su tehnologija (lanac operacija) i tehnološki izbori, osobito praksa pripreme lončarske smjese kao i tehnike gradnje ili pečenja posuda, ali i veze između tehnologije i uporabnih svojstava odnosno funkcije posuda. Informacije proizašle iz prirodnih znanosti, predstavljaju metodološku osnovu za humanistička razmatranja arheološki nevidljivih fenomena. Stoga je cilj tako postavljenog istraživanja tumačenje veza između tehnoloških izbora i lončarske prakse te varijabilnosti u keramičkoj tehnologiji čime ona postaje dokaz postojanja izbora koji su diktirani kulturnom pozadinom zajednice u okviru koje se odvijala proizvodnja i uporaba. U sklopu istraživanja će se uspostaviti i referentna zbirka arheološko-geoloških uzoraka te digitalna baza podataka otvorenog tipa za proučavanje lončarskih tehnoloških tradicija brončanodobnih zajednica na području RH.]]></summary_hr><summary_en><![CDATA[The aim of the project is to establish an interdisciplinary research group of young scientists (archeology and geology) and to direct it towards a systematic study of the Bronze Age pottery traditions on the territory of Croatia. The study is planned to be conducted over a wide area, especially in areas that have been least explored, but crucial in terms of cultural influences, communication routes and technology practices and knowledge exchange between the eastern Adriatic region and its hinterland, with the southern Pannonian Plain. The research is therefore divided into several study areas: central Croatia, Lika and Gorski Kotar, Istria and the northern Adriatic, northern and central Dalmatia, and eastern Croatia. Pottery technology, function and use of the ceramic vessels, and cultural practices in prehistoric pottery traditions open up an intact field of research in these areas, allowing a whole new approach to the study of prehistoric cultural groups. In line with such an approach, the analytical focus is particularly on technology (chain of operations) and technological choices, especially the practice of preparing clay paste, as well as building techniques and, firing methods, but also the relationship between technology and the use-related properties of the vessels. Information derived from the natural sciences (archaeometry of ceramic materials) will provide a methodological basis for considering humanistic perspectives and archaeologically invisible phenomena. Therefore, the aim is to interpret the links between technological choices and pottery practice, and variability in ceramic technology, thereby making it the evidence of choices dictated by the cultural background of the community within which the production and use took place. The research will produce a reference collection of archaeo-geological samples as well as an open-source database for the study of technological traditions of Bronze Age communities.]]></summary_en></project><project>
<id>10081</id><title_hr><![CDATA[Višerazinske konfiguracije organizacijskog dizajna: Razumijevanje dualnosti između heterogenosti i homogenosti]]></title_hr><title_en><![CDATA[Multilevel organization design configurations: Understanding the heterogeneity–homogeneity duality]]></title_en><user_id>5575</user_id><user_firstLast_name>Tomislav Hernaus</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2020-02</proposal_call><code>IP-2020-02-8889</code><acronim><![CDATA[MULTIORGDUAL]]></acronim><duration>20.01.2021 - 19.01.2025</duration><status>Završio</status><financ_value>97.940,58 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, Sociologija, Psihologija, </scie_field_hr><scie_field_en>Economy, Sociology, Psychology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Ekonomski fakultet u Zagrebu]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Economics and Business]]></institution_en><team_members_id>22840, 29626, 26579, 5834, 26656, 12896, 26573, 27069, 29613, 13589, 27166, 26742, 864933, 865157, 866595, 7294, 7095, 29318, 855444, </team_members_id><team_members_names><![CDATA[Matija Marić, Kristina Potocnik, Sasa Batistic, Ivan Matić, Ana Juras, Matej Černe, Aleša Saša Sitar, Arnold Bakker, Miha Škerlavaj, Maja Klindžić, Nicolay Worren, Ana Aleksic Miric, Nikolina Dragičević, Ante Budimir-Bekan, SARA MELKIĆ Melkić, Vesna Vašiček, MARTINA DRAGIJA KOSTIĆ, Ivana Pajković, Matko Ljubić, ]]></team_members_names><keywords_hr><![CDATA[organizacijski dizajn, organizacijske konfiguracije, kvalitativna komparativna analiza, dualnost heterogenosti i homogenosti, višerazinski pristup]]></keywords_hr><keywords_en><![CDATA[organization design, organizational configurations, qualitative comparative analysis, heterogeneity-homogeneity duality, multilevel approach]]></keywords_en><summary_hr><![CDATA[Dosadašnja istraživanja uglavnom slijede nerealne pretpostavke o homogenizaciji organizacijskih karakteristika. Međutim, upravo povezivanje i promatranje različitih organizacijskih praksi može dodati vrijednost. Slijedom toga, glavna svrha ovog istraživanja jest utvrditi i objasniti kako i zašto dolazi do razlika u uspješnosti uslijed odluka o organizacijskom dizajnu napravljenih na različitim razinama analize (pojedinac/posao, tim/jedinica i organizacija/sustav). Namjeravamo prepoznati višerazinske obrasce dizajniranja organizacija koji proizlaze iz različitih organizacijskih dualnosti (strateška, strukturalna i heterogenost upravljanja ljudima). Polazeći od teorije složenosti i primjenom konfiguracijskog pristupa bit će istraženi složeni međuodnosi struktura i praksi s gledišta jednakokonačnosti. Predloženi dizajn istraživanja obuhvaća provođenje tri studije i podrazumijeva korištenje mješovite metodologije. Prva studija predstavlja anketno istraživanje prakse dizajna organizacije i organizacijskih jedinica na uzorku hrvatskih, slovenskih i srbijanskih organizacija s ciljem utvrđivanja postojećih internih sposobnosti organizacijskog dizajna, kao i obrazaca organiziranja koji pozitivno ili negativno utječu na poslovni rezultat. Druga studija obuhvatit će akcijsko istraživanje u tri partnerske organizacije pri čemu će naglasak biti na utvrđivanju kako povezanost dizajna organizacijskih jedinica i dizajna posla utječe na radnu uspješnost zaposlenika. Konačno, treća studija omogućit će kreiranje modela zrelosti organizacijskog dizajna kroz primjenu Delfi tehnike na uzorku stručnjaka za organizacijski dizajn. Planirano istraživanje nastojat će potaknuti širenje znanja o dizajniranju učinkovitih organizacija ali i istaknuti koji obrasci ponašanja vode ka neuspjehu. ]]></summary_hr><summary_en><![CDATA[The existing research mainly followed unrealistic homogenizing assumptions of organizational attributes, not realizing that the association of heterogeneous organizational practices may add value. Therefore, the main purpose of our research is to determine and explain how and why performance differences emerge from design choices made at different levels of analysis (individual/job, team/unit and organization/system). We intend to search for multi-level organization designing patterns emerging from different organizational dualities (strategic, structural and HRM heterogeneity). Starting from the theory of complexity and using the configurational approach we will study the complex interplay of structures and practices from an equifinal point of view.The proposed research design includes three studies and applies a mixed research methodology. The first study represents a field survey research of organizational and business unit design on the sample of Croatian, Slovenian and Serbian companies. The aim is to identify the current level of internal organizational design capabilities, as well as to recognize organizational configurations which have either positive or negative effect on business unit performance. The second study is an action research within three partner organizations through which we plan to address how the relationship between business unit design and job design influences employee work performance. Finally, the third study will result in the organizational design maturity model development. A Delphi method will be used to target the sample of organizational design experts. The planned research is expected to enhance knowledge dissemination about designing effective organizations, as well as emphasize organizational configurations that are likely to result in failure.]]></summary_en></project><project>
<id>10087</id><title_hr><![CDATA[TESTIRANJE 5C MODELA POZITIVNOG RAZVOJA MLADIH: TRADICIONALNO I DIGITALNO MOBILNO MJERENJE]]></title_hr><title_en><![CDATA[TESTING THE 5C FRAMEWORK OF POSITIVE YOUTH DEVELOPMENT: TRADITIONAL AND DIGITAL MOBILE ASSESSMENT]]></title_en><user_id>12543</user_id><user_firstLast_name>Miranda Novak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2020-02</proposal_call><code>UIP-2020-02-2852</code><acronim><![CDATA[P.R.O.T.E.C.T.]]></acronim><duration>01.04.2021 - 31.03.2026</duration><status>U tijeku</status><financ_value>166.390,21 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Edukacijsko-rehabilitacijske znanosti, Psihologija, Socijalne djelatnosti, </scie_field_hr><scie_field_en>Physical education and rehabilitation sciences, Psychology, Social work, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Edukacijsko-rehabilitacijski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Education and Rehabilitation Sciences]]></institution_en><team_members_id>13404, 26669, 12503, 23377, 5261, 25386, 865221, </team_members_id><team_members_names><![CDATA[Josipa Mihić, Nicholas Parr, Gabrijela Vrdoljak, Toni  Maglica, Darko Roviš, Hana Gačal, Lucija Šutić, ]]></team_members_names><keywords_hr><![CDATA[pozitivan razvoj mladih, adolescencija, 5C model, razvojne prednosti, razvojne putanje]]></keywords_hr><keywords_en><![CDATA[positive youth development, adolescence, 5C framework, developmental assets, developmental trajectories]]></keywords_en><summary_hr><![CDATA[Okosnica predloženog istraživanja je teorijski okvir pozitivnog razvoja mladih (Leffert i sur., 1998; Benson, Scales, Hamilton i Sesma; 2006; Benson, Scales i Syversten, 2011; Lerner i sur., 2013), koji se konceptualno veže s teorijom ekoloških sustava, razvojnim kontekstualizmom te razvojnom psihopatologijom. Pozitivan razvoj mladih predstavlja teorijski pristup koji proučava snage i kompetencije mladih te pozitivne razvojne ishode koji se događaju kada mladi tijekom svog odrastanja imaju iskustva s brižnim i podržavajućim odraslim osobama, sustavima i zajednicama. Budući da je pristup pozitivnog razvoja konceptualno širok, predlaže se testiranje 5C modela pozitivnog razvoja i razvojnih prednosti. Opći cilj ovog projekta jest provjera 5C modela pozitivnog razvoja kako bi se produbilo razumijevanje interakcije karakteristika mlade osobe i karakteristika okruženja u kojima mladi žive te ispitalo ulogu pozitivnog razvoja u predviđanju razvojnih ishoda adolescenata. Planirana je provedba 1)longitudinalnog višerazinskog istraživanja  u 3 tj. 4 vala, ovisno o trogodišnjem ili četverogodišnjem tipu srednje škole, te 2) intenzivnog longitudinalnog mobilnog mjerenja. Višerazinsko longitudinalno mjerenje uključuje početni uzorak od 6 100 adolescenata prvih razreda srednjih škola, njihovih 1200 roditelja te 200-njak razrednika uključenih razreda. U studiju s intenzivnim longitudinalnim mobilnim praćenjem bit će uključen prigodni uzorak od 600 učenika, 10% istih učenika koji će sudjelovati u istraživanju  u svojim srednjim školama. Adolescenti će instalirati aplikaciju EARS (Nicholas B. Allen, University of Oregon) na mobilne telefone kako bi se metodom momentarne procjene njihove podatke prikupljalo intenzivno kroz sedam dana godišnje kroz 3 do 4 vala. Prednost projekta predstavlja njegov međunarodni tim i suradnja sa Sveučilištem u Oregonu te korištenje inovativnog longitudinalnog digitalnog mjerenja.]]></summary_hr><summary_en><![CDATA[Background of proposed research is positive youth development framework (Leffert et al, 1998; Benson, Scales, Hamilton & Sesma; 2006; Benson, Scales & Syversten, 2011; Lerner et al, 2013), conceptually related with with developmental ecology, developmental contextualism and developmental psychopathology frameworks. The positive development approach is focused on adolescents’ strengths, competencies and positive outcomes that occur when youth engage with caring and supportive adults, systems and communities during the developmental period. Since positive youth framework itself is quite broad, this project proposes testing the 5C model of positive youth development and developmental assets. General aim of this project is to test the 5C positive youth model in order to deepen the understanding of youth characteristics and environmental characteristics interaction and to examine the role of positive youth development in predicting adolescent developmental outcomes. To answer the proposed aim, we plan to conduct: 1) longitudinal multi-level 3 to 4 wave assessment, depending if included adolescent is in 3-year or 4-year high-school program; and 2) intensive longitudinal mobile assessment. Longitudinal multi-level assessment will include baseline sample of 6100 adolescents from the first high-school grade, their 1200 parents and 200 head-teachers of included classrooms. Study with intensive longitudinal mobile assessment will include a sample of 600 adolescents, that being 10% of students that will take part in the baseline assessment in their schools. Adolescents included in this part will install EARS app (Nicholas B. Allen, University of Oregon) on their mobile phones in order to assess their data via ecological momentary assessment method intensively during seven days within 3 to 4 waves. The project advantage is ts international team and collaboration with University of Oregon and innovative method of intensive longitudinal digital assessment. ]]></summary_en></project><project>
<id>10090</id><title_hr><![CDATA[Istraživanje interakcija između regulatornih varijanti u kontekstu bolesti čovjeka]]></title_hr><title_en><![CDATA[Exploring interactions between regulatory variants in human disease context]]></title_en><user_id>4183</user_id><user_firstLast_name>Anja Barešić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2020-02</proposal_call><code>UIP-2020-02-1623</code><acronim><![CDATA[IntRegVar]]></acronim><duration>01.01.2021 - 30.06.2026</duration><status>U tijeku</status><financ_value>220.922,69 eur</financ_value><scie_area_hr>Interdisciplinarno područje znanosti</scie_area_hr><scie_area_en>Interdisciplinary scientific area</scie_area_en><scie_field_hr>Biotehnologija u biomedicini, </scie_field_hr><scie_field_en>Biotechnology in Biomedicine, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>864967, 865112, 864917, </team_members_id><team_members_names><![CDATA[Filip Uljanić, Katarina Prskalo, Dalibor Hršak, ]]></team_members_names><keywords_hr><![CDATA[regulacija gena, nekodirajuće varijacije, bolest, cjelogenomska asocijacijska istraživanja, regulatorna genomika]]></keywords_hr><keywords_en><![CDATA[gene regulation, non-coding variation, disease, GWAS, regulatory genomics]]></keywords_en><summary_hr><![CDATA[Cjelogenomska asocijacijska istraživanja (GWAS) su moćan alat za otkrivanje čestih varijanti povezanih s bolešću, ali do danas nisu uspjeli riješiti nedostajuće nasljeđe za mnoge bolesti. Glavni problem u rasvjetljavanju novih mehanizama složenih bolesti je posljedica činjenice da je većina GWAS varijanti u nekodirajućim regijama i povezuje ih se s najbližim genima u genomskom prostoru, ignorirajući brojne dokaze o reguliranju gena dugog dometa, što rezultira listama gena minimalnog presjeka između studija te niskim postotkom eksperimentalne validacije.Predloženi projekt adresira taj glavni problem predviđanja ciljnih gena. Prvo, nedavno razvijena metoda bit će usavršena proširivanjem skupa podataka koji se koriste za otkrivanje povezanosti pojačivača i promotora u različitim prostorno-vremenskim kontekstima kod ljudi i raspona varijanti za koje se daju predviđanja. Konačno, koristeći mnoštvo informacija o svim ljudskim bolestima sa značajnom genetskom komponentom, ovaj će se projekt usredotočiti na epistatske interakcije između lokusa.Ovdje predloženi rad će produbiti uspostavljenu međunarodne suradnje, kako s kliničkim istraživačima koji imaju pristup relevantnim podacima o pacijentima, a kasnije i s eksperimentalnim biolozima sa ekspertizom u validaciji nekodirajućih funkcionalnih elemenata u relevantnom modelnom organizmu. Dosadašnje iskustvo u radu s kliničkim znanstvenicima na bolestima poput shizofrenije, makularne degeneracije i ne-sindromskog neurorazvojnog kašnjenja pokazalo je da su alati za automatsko tumačenje javno dostupnih podataka, pretvorbe rezultata u eksperimentalne teze ili sužavanje kandidata za validaciju, i presudno, priopćavanje novih nalaza u kliničarima razumljivom jeziku nužni za ubrzavanje translacijskog napretka u ovom polju. Planiram prenijeti svoje iskustvo rada u multidisciplinarnim timovima i snažno se zalažem za suradnju među različitim poljima, po mogućnosti prenoseći to znanje studentima ako se ukaže prilika.]]></summary_hr><summary_en><![CDATA[Genome-wide association studies emerged as a powerful tool to detect common variants associated with the disease, but up to this date fail to address missing heritability for many diseases. The main issue in elucidating novel mechanisms of complex diseases is due to the majority of GWAS variants being non-coding, and linking them to the closest gene in genomic space ignoring ample evidence of long-range gene regulation, resulting in gene lists with poor reproducibility between the studies and low rates of experimental validation.Proposed project addresses this major caveat in target gene prediction. First, a recently developed method will be refined by extending the range of datasets used to detect enhancer-promoter associations over different spatiotemporal contexts in humans, and the range of variants for which the predictions are made. Finally, utilising a wealth of information on all human diseases with significant genetic component, this project will focus on epistatic interactions between the loci. The work proposed here will ultimately deepen established international collaborations, with both clinical researchers who have access to pertinent patient data, and later experimental biologists with expertise in validation of non-coding functional elements in relevant model organism for human diseases. Previous experience in working with clinical scientists on diseases like schizophrenia, macular degeneration and non-syndromic neurodevelopmental delay indicated that having means to interpret publicly available data in an automated way, translating findings into experiments, or narrowing down candidates for the validation, and crucially, communicating novel findings in form understandable to clinicians is necessary to speed up translational advancements in this field. I am planning to bring my experience in working in multidisciplinary teams and strongly advocate for collaborations across fields, preferably teaching it to students if opportunity arises.]]></summary_en></project><project>
<id>10092</id><title_hr><![CDATA[Hibridno modeliranje pobuđenih stanja u novim molekularnim materijalima: od optičkih svojstava do dinamike ekscitona]]></title_hr><title_en><![CDATA[Hybrid modeling for excited states in novel molecular materials: from optical properties to exciton dynamics]]></title_en><user_id>866630</user_id><user_firstLast_name>Prlj Antonio</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2020-02</proposal_call><code>IP-2020-02-7262</code><acronim><![CDATA[HYMO4EXNOMOMA]]></acronim><duration>25.01.2021 - 24.06.2025</duration><status>U tijeku</status><financ_value>136.571,77 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Interdisciplinarne prirodne znanosti, Fizika, Kemija, </scie_field_hr><scie_field_en>Interdisciplinary natural sciences, Physics, Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>27083, 27135, 27102, 29669, 865444, 25534, 869936, 871140, </team_members_id><team_members_names><![CDATA[Anna Painelli, Gabriele D&amp;#39;Avino, Ali Hassanali, Goran Zgrablić, Miha Gunde, Luca Grisanti, Haseena Sheik, CHAIYAPORN LAKMUANG, ]]></team_members_names><keywords_hr><![CDATA[računalna znanost o materijalima, molekularni materijali, eksitoni, pobuđena stanja, optička svojstva, modeliranje, strojno]]></keywords_hr><keywords_en><![CDATA[computational material science, molecular materials, excitons, excited states, optical properties, modeling, machine learning]]></keywords_en><summary_hr><![CDATA[U projektu se pomoću teorijskog i računalnog modeliranja istražuju pobuđena stanja i optička svojstva molekularnih materijala uz pomoć novih hibridnih metodologija. Prvi korak je definiranje strukture molekularnog kristala ili agregata koji se istražuje. Struktura se dobiva ili direktno iz eksperimenta ili se pretpostavlja pomoću računalnih modela. Zatim, iz simulacija pobuđenih stanja i molekularne dinamike dobivaju se parametri hamiltonijana koji opisuju ekscitone. Također će se razviti sučelje za algoritme za strojno učenje, koje će omogućiti poboljšanje parametriranja modelnih hamiltonijana, omogućavajući tako potpuni uvid u fiziku ekscitona na automatizirani način. U model će biti ugrađene mikroskopske informacije koje će dati uvid u optička svojstva i svojstva ekscitonske dinamike, koja će se usporediti i potvrditi u odnosu na eksperimente. Istraživani sustavi uključivat će inovativne organske i bio-molekularne materijale, nudeći ovom projektu priliku za razumijevanje i kontrolu njihovih raznolikih i perspektivnih optičkih svojstava.]]></summary_hr><summary_en><![CDATA[The project investigates theoretical and computational modeling of excited states and optical properties in molecular materials through hybrid methodological approaches. The scheme require first to provide a structures of molecular crystals or aggergate, either obtained from experiment or guessed via computational tools. Exciton model hamiltonians will be fed by excited-state calculations and ab-initio molecular dynamics, to derive hamiltonian parameters. The interface of ad-hoc developed machine learning (ML) algorithms will be also developed, allowing ML to improve the parametrization of the model hamiltonian, hence providing a full insight into excitons physics in an automatized fashion. The model will embed microscopical information that will translate into optical and exciton dynamical properties, to be finally compared and validated against experiments. Systems investigated will include innovative organic and bio- molecular materials, offering this project the chance to understand and control their diverse and promising optical properties.]]></summary_en></project><project>
<id>10093</id><title_hr><![CDATA[Inovativna lagana međukatna konstrukcija – spregnuti sustav hladno oblikovani čelik i beton]]></title_hr><title_en><![CDATA[Innovative lightweight cold-formed steel-concrete composite floor system]]></title_en><user_id>24476</user_id><user_firstLast_name>Ivan Lukačević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2020-02</proposal_call><code>UIP-2020-02-2964</code><acronim><![CDATA[LWT-FLOOR]]></acronim><duration>11.01.2021 - 10.01.2026</duration><status>U tijeku</status><financ_value>222.217,80 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Građevinarstvo, </scie_field_hr><scie_field_en>Civil engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Građevinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Civil Engineering]]></institution_en><team_members_id>21350, 26558, 29656, 27187, 29736, 855305, 865239, 865232, 869861, </team_members_id><team_members_names><![CDATA[Ivan Ćurković, Marko Bartolac, Šime Serdarević, Marko Ptiček, Florin Liviu Bodea, Ivan Čudina, Andrea Rajić, Vlaho Žuvelek, Emanuel Krupa-Jurić, ]]></team_members_names><keywords_hr><![CDATA[točkasto zavarivanje, međukatna konstrukcija, posmična veza, sastavljeni, mogućnost ponovne uporabe, probabilistički pristup, analiza životnog ciklusa]]></keywords_hr><keywords_en><![CDATA[spot welding, composite floor system, shear connection, built-up, reusability, probabilistic aproaches, lifecycle analysis]]></keywords_en><summary_hr><![CDATA[Projekt LWT-FLOOR povezuje najnovije spoznaje u novoj, brzoj i produktivnoj tehnologiji točkastog zavarivanja i inovativna rješenja sprezanja hladno oblikovanog čelika i betona predlažući novu metodu izgradnje kao kombinaciju sastavljenih hladno oblikovanih čeličnih elemenata i betonske ploče. Ovaj ekonomičan i održiv sustav lagane međukatne konstrukcije nudi vitalne prednosti u smislu visokog stupnja predgotovljenosti, mogućnosti ponovne upotrebe i mogućih velikih raspona. Glavni cilj projekta je uspostaviti novu istraživačku grupu koja će posjedovati znanje i opremu za istraživanje novog sustava međukatne konstrukcije s fokusiranim znanstvenim interesima u potrazi za konkurentnijim nacionalnim i međunarodnim financiranjem. Kako bi se istražile i vrednovale komponente i predloženi sustav u cjelini, planira se opsežno eksperimentalno, numeričko i probabilističko istraživanje. U okviru istraživanja posebna pozornost će biti posvećena točkastim zavarima i inovativnim vrstama posmične veze s mogućnošću projektiranja za demontažu i potencijalom za buduće ponovne uporabe ili recikliranja na kraju životnog vijeka uključujući primjenu analize životnog ciklusa. Kalibrirani numerički modeli temeljeni na eksperimentalnim ispitivanjima sustava i njegovih komponenata omogućit će, uz primjenu probabilističkih metoda, procjenu prikladnosti sustava za veće raspone. Projekt će donijeti nove vještine istraživačkoj grupi i istraživačkoj instituciji, a pored toga obranit će se i dvije disertacije te objaviti znanstveni radovi u najcitiranijim časopisima. Ovaj inovativni projekt, koji osigurava čvrste veze između akademske zajednice i industrije, povećat će mobilnost i ojačati dugoročnu suradnju između dva sektora. Probabilističke analize i procjene ponašanja predloženog rješenja u životnom ciklusu međukatne konstrukcije bit će od ključnog značaja za pripremu prvog analitičkog prijedloga za izradu preporuka za projektiranje ovog novog sustava u okviru europskih norma.]]></summary_hr><summary_en><![CDATA[The LWT-FLOOR project integrates state-of-the-art knowledge in new, fast and productive spot-welding technology and innovative cold-formed steel-concrete composite solutions proposing a new construction method as a combination of built-up cold-formed steel members and cast-in-place concrete slab. This cost-effective and sustainable floor system offers vital benefits in terms of a high degree of prefabrication, reusability and long spanning capability. The main objective of the project is to establish a new research group that will possess knowledge and equipment for research on new composite floor system with focused scientific interests in a search for more competitive national and international funding. In order to investigate and validate components and proposed system, the extensive experimental, numerical and probabilistic research is planned. Within research, a particular focus will be given to spot-welding connections and innovative types of shear connections with possibility of design for demountability and the potential of re-use or recycling at the end of design life through the application of lifecycle analyses. Calibrated and validated numerical models based on experimental tests of the system and its components will allow, through the application of probabilistic methods, evaluation of the system suitability for larger spans. The project will bring out new skills to the research group and the research institution, besides which two dissertations will be defended and scientific papers in most cited journals will be published. This innovative project, providing strong connections between the scientific community and industry, will increase the mobility as well as strengthen long-term cooperation between the two sectors. Probabilistic analyses and life cycle performance evaluation of the proposed floor system solution will be crucial for establishing the first analytical proposal for design recommendations of this new system within the European standards.]]></summary_en></project><project>
<id>10094</id><title_hr><![CDATA[Kolektivna pobuđenja i lokalna struktura u nekonvencionalnim supravodičima]]></title_hr><title_en><![CDATA[Collective excitations and local structure in unconventional superconductors]]></title_en><user_id>3109</user_id><user_firstLast_name>Damjan Pelc</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2020-02</proposal_call><code>UIP-2020-02-9494</code><acronim><![CDATA[CELUS]]></acronim><duration>01.01.2021 - 30.06.2026</duration><status>U tijeku</status><financ_value>262.791,16 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>865218, 865494, 865495, </team_members_id><team_members_names><![CDATA[Marin Spaić, Noah Somun Somun, Luka Rogić Rogić, ]]></team_members_names><keywords_hr><![CDATA[nekonvencionalni supravodiči, nehomogenost na nano-skali, lokalna struktura, kolektivna pobuđenja, plastična deformacija]]></keywords_hr><keywords_en><![CDATA[unconventional superconductors, nanoscale inhomogeneity, local modes, collective excitations, plastic deformation]]></keywords_en><summary_hr><![CDATA[Nekonvencionalni supravodiči spadaju među najvažnije kvantne materijale, uz mnoštvo fundamentalnih otvorenih pitanja i potencijalnih primjena. Unutar ovog projekta koristit ćemo nekoliko komplementarnih, inovativnih eksperimentalnih tehnika, koje će omogućiti nove uvide u fiziku nekonvencionalne supravodljivosti. Cilj je odgovoriti na tri povezana pitanja: kako lokalna kristalna struktura, odnosno atomske korelacije na nanometarskim skalama, utječe na supravodljivost; može li se lokalna struktura kontrolirano mijenjati primjenom plastične deformacije i time optimizirati supravodljiva svojstva; te kako strukturne korelacije utječu na niskoenergetska elektronska kolektivna pobuđenja. Istraživat ćemo neke od najvažnijih nekonvencionalnih supravodiča: kompleksne okside poput kuprata, rutenata i titanata, te materijale s teškim fermionima. Koristit ćemo napredne eksperimentalne tehnike koje su posebno osjetljive na lokalnu strukturu i pobuđenja, poput nuklearne magnetske rezonancije, difuznog raspršenja x-zraka i neutrona, te razviti jedinstveni sustav za mikrovalnu spektroskopiju. Također, razvijat ćemo specijalizirane ćelije za uniaksijalni tlak, koje će omogućiti in situ mjerenja strukturnih i elektronskih svojstava. Unutar novoosnovane istraživačke grupe, studenti će naučiti koristiti napredne eksperimentalne tehnike u vrhunskim korisničkim laboratorijima u svijetu, te produbljivati suradnju s partnerima u SAD i Europi.]]></summary_hr><summary_en><![CDATA[Unconventional superconductors are among the most investigated quantum materials, with many key open questions and tremendous potential for applications. Within the proposed research, we will address three fundamental, related questions: the role of local, nanoscale structural correlations in superconducting pairing; the possibility of tuning and optimization of superconducting properties using irreversible, plastic deformation of single crystals; and the interplay between structure and collective electronic correlations. We will investigate some of the most important unconventional superconductors: complex oxides such as the high-Tc cuprates, ruthenates and strontium titanate, as well as heavy-fermion materials. To achieve the project goals, we will use advanced experimental techniques that are sensitive to local structure and excitations, including nuclear magnetic resonance, diffuse X-ray and neutron scattering, and high-frequency microwave spectroscopy. Furthermore, we intend to develop specialized uniaxial pressure cells, that will enable in situ studies of structural and electronic properties. Within the newly formed research group, students will be trained to use cutting-edge experimental techniques at some of the most advanced user facilities world-wide, and foster collaborations with partners in the USA and Europe.   ]]></summary_en></project><project>
<id>10099</id><title_hr><![CDATA[Plazmoni i eksiton-polaritoni u kvazi-2D kristalima]]></title_hr><title_en><![CDATA[Plasmons and exciton-polaritons in quasi-2D crystals]]></title_en><user_id>4933</user_id><user_firstLast_name>Vito Despoja</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2020-02</proposal_call><code>IP-2020-02-5556</code><acronim><![CDATA[2DPlasEx]]></acronim><duration>01.02.2021 - 30.06.2025</duration><status>Završio</status><financ_value>129.802,91 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut za fiziku]]></institution_hr><institution_en><![CDATA[Institute of Physics in Zagreb]]></institution_en><team_members_id>26143, 864851, 867852, </team_members_id><team_members_names><![CDATA[Dino Novko, Josip Jakovac, Neven Golenić, ]]></team_members_names><keywords_hr><![CDATA[plazmoni, eksitoni, fononi, polaritoni, 2D kristali, spektroskopija  ]]></keywords_hr><keywords_en><![CDATA[plasmons, excitons, phonons, polaritons, 2D crystals, spectroscopy ]]></keywords_en><summary_hr><![CDATA[Cilj ovog projekta je istražiti elektromagnetske modove u vodljivim i poluvodičkim 2D kristalima poput grafena ili heksagonalnog borovog-nitrida (hBN) dopiranih atomima alkalijskih metala (Li, K, Cs)  ili u dihalkogenidima prijelaznih metala (TMDs). Naglasak ce biti na izučavanju  inteziteta i disperzijskih relacija kolektivnih elektromagnetskih modova, tj. plazmon-polaritona i eksiton-polaritona u 2D kristalima.  Istraživanje će se provesti u okviru mnogočestične perurbacijske teorije, točnije riješavati će se Bethe-Salpeterova jednadžba u kojoj će se kao baza koristiti DFT osnovno stanje dobiveno pomoću programskog paketa QuantumEspresso. U mnogočestični formalizam biti će uključeni efekti retardacije, interakcija (raspad i hibridizacija) plazmon-polaritona sa fononima te utjecaj metalnog ili poluvodičkog substrata na elektromagnetska svojstva 2D kristala. Ovo  metodu  čini superiornijom u odnosu na dosad korištene metode  i omogućiti će otkrivanje novih još neistraženih fenomena. Razumijevanje novih fenomena moglo bi pomoći u proizvodnji nove klase optoelektroničkih uređaja kao što su 2D fotodetektori, fotodiode ili fotonaponski uređaji ili plinski, kemijski i organski detektori. Na poslijetku, razumjevanje interakcije plazmon-polaritona sa LO fonona u dopiranim 2D kristalima moglo bi razjasniti granice primjenjivosti plazmon-polaritona u telekomunikacijama.      ]]></summary_hr><summary_en><![CDATA[The aim of this project is to investigate electromagnetic modes in conductive and semiconductive 2D crystals such as graphene or hexagonal boron-nitride (hBN) dopedby alkali metals (Li, K, Cs) or in transition-metal-dichalcogenide monolayers (TMDs). The emphasis will be on the study of the intensity and dispersion relations of the collectiveelectromagnetic modes, i.e. plasmon-polaritons and exciton-polaritons in 2D crystals. The investigation will be provided in the framework of the many-body perturbationtheory, i.e. by solving the Bethe-Salpeter equation in which enters the DFT ground state base-set obtained using the software package QuantumEspresso. Used many-body formalism include the effects of retardation, interaction (decay and hybridization) of plasmon-polaritons with phonons and the influence of a metallic or semiconductive  substrate on electromagnetic properties in 2D crystals. This makes the method superior to the methods used so far and will allow exploration of new phenomena. Understanding new phenomena could help in fabrication of a new class of optoelectronic devices such as 2D photodetectors, photodiodes or photovoltaic devices or gas, chemical and organic detectors. Finally, understanding the interaction of plasmon-polaritons with LO phonons in doped 2D crystals could clarify the applicability limits of plasmon-polaritons in telecommunications.]]></summary_en></project><project>
<id>10101</id><title_hr><![CDATA[Fotonsko sinteriranje inkjet ispisanih elektrokemijskih senzora i biosenzora na plastičnim podlogama]]></title_hr><title_en><![CDATA[Photonic sintering for inkjet printed electrochemical sensors and biosensors on plastic substrates]]></title_en><user_id>24859</user_id><user_firstLast_name>Petar Kassal</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2020-02</proposal_call><code>UIP-2020-02-9139</code><acronim><![CDATA[PrintEChemSens]]></acronim><duration>15.12.2020 - 14.03.2026</duration><status>U tijeku</status><financ_value>262.300,09 eur</financ_value><scie_area_hr>Prirodne znanosti, Tehničke znanosti, </scie_area_hr><scie_area_en>Natural sciences, Technological sciences, </scie_area_en><scie_field_hr>Kemija, Kemijsko inženjerstvo, </scie_field_hr><scie_field_en>Chemistry, Chemical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet kemijskog inženjerstva i tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Chemical Engineering and Technology]]></institution_en><team_members_id>29465, 29756, 29689, 864918, 865194, 867603, </team_members_id><team_members_names><![CDATA[Irena Ivanišević, Magdalena Kralj, Ivana Ćevid, Sara Krivačić, Marko Zubak, Željka Boček, ]]></team_members_names><keywords_hr><![CDATA[Elektrokemijski senzori, Biosenzori, Inkjet senzori, Printana elektronika, Fotonsko sinteriranje, Nosivi senzori, mikrofluidika, Lab-on-a-Chip]]></keywords_hr><keywords_en><![CDATA[Electrochemical sensors, Biosensors, Inkjet printed sensors, Printed electronics,  Photonic sintering, Wearable sensors, microfluidics, Lab-on-a-Chip]]></keywords_en><summary_hr><![CDATA[Rasprostranjenost elektrokemijskih (bio)senzora potrebna je kako bi se riješila goruća globalna pitanja, primarno iz područja zdravstva i zaštite okoliša. Širenje senzora trenutno usporava nedostatak jeftinih i brzih proizvodnih tehnologija, ali to se može riješiti primjenom provjerenih tehnologija iz područja printane elektronike. Konkretno, inkjet ispis je prilagodljiva i jeftina tehnologija kompatibilna s masovnom proizvodnjom koja omogućava izradu cijelih (bio)kemijskih senzora uz manje otpada. Glavni cilj ovog projektnog prijedloga je uspostava neovisne istraživačke grupe fokusirane na razvoj inkjet ispisanih elektrokemijskih senzora i biosenzora. Istraživanje tijekom projekta provodit će se od sinteze vodljivih tinti temeljenih na nanočesticama metala (Au, Ag, Cu) i ugljika (ugljikove nanocjevčice, grafen, grafen-oksid) ili vodljivim polimerima, do razvoja planarnih čvrstih ion selektivnih elektroda i amperometrijskih biosenzora inkjet ispisom.  Kako bismo unaprijedili razvoj, koristit ćemo fotonsko sinteriranje te ćemo razjasniti utjecaj te tehnologije na morofološka i električna svojstva nanočestica, kao i na analitičku izvedbu novih senzora. Tijekom projekta, razvit ćemo na plastičnim podlogama jeftine ali robusne senzore za određivanje važnih analita u nosivim sustavima  za analizu znoja (elektroliti) te ključnih analita u zaštiti okoliša (farmaceutici i pesticidi). Naposljetku, integrirat ćemo razvijeni inkjet ispis senzora s 3D tiskanjem mikrofluidičkih uređaja kako bismo razvili visoko integrirane printane Lab-on-a-Chip uređaje.  Kroz efektivnu diseminaciju i suradnju osigurat ćemo znatan utjecaj projekta, olakšati prodore u druga srodna područja printane elektronike i pronaći izvore vanjskog financiranja te na taj način omogućiti nastavak istraživačkih aktivnosti grupe i nakon završetka projekta. ]]></summary_hr><summary_en><![CDATA[Widespread distribution of electrochemical (bio)sensors is needed to solve pressing  global challenges in different areas, particularly healthcare and environmental monitoring. Their propagation is currently hindered by a lack of  high throughput, cost-effective fabrication of electrochemical sensing devices, but this can be solved by employing established technologies from printed electronics. Specifically, inkjet printing is a highly versatile, scalable and low-cost fabrication technology, which enables development of entire (bio)chemical sensors with less waste. The main goal of this project proposal is establishment of an independent research group working on the development of inkjet-printed electrochemical sensors and biosensors. Research during the project will be conducted from the  synthesis of conductive inks based on metal (Au, Ag, Cu) and carbon (carbon nanotube, graphene, graphene-oxide) nanoparticles or conducting polymers, to the development of planar solid state ion-selective electrodes and amperometric biosensors by inkjet printing. To improve this development, we will employ photonic sintering and elucidate its effects on nanoparticle morphological and electrical characteristics and on the analytical performance of novel sensors. During the project, we will develop low-cost but robust sensors on plastic substrates, for the detection of important analytes in wearable sweat sensing (electrolytes) and environmental protection (drugs and pesticides). Ultimately, we will integrate inkjet printing of sensors with 3D-printed microfluidics to develop  all-printed highly integrated Lab-on-a-Chip devices. Through effective dissemination and collaboration, we will ensure substantial impact of the project , facilitate breakthroughs into other related areas of printed electronics, and acquire additional funding, thus enabling continuation of the group&#39;s research activities beyond the project&#39;s end.]]></summary_en></project><project>
<id>10102</id><title_hr><![CDATA[Istraživanje paleoklimatske varijabilnosti visoke rezolucije pomoću posrednih pokazatelja u sigama iz Nove Grgosove spilje]]></title_hr><title_en><![CDATA[Unlocking high-resolution palaeoclimate variability from Nova Grgosova cave multi-proxy speleothem record ]]></title_en><user_id>25947</user_id><user_firstLast_name>Petra Bajo</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2020-02</proposal_call><code>UIP-2020-02-7355</code><acronim><![CDATA[UNLOCK-CAVE]]></acronim><duration>03.10.2022 - 02.10.2027</duration><status>U tijeku</status><financ_value>254.076,18 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Geologija, </scie_field_hr><scie_field_en>Geology, </scie_field_en><institution_hr><![CDATA[Hrvatski geološki institut]]></institution_hr><institution_en><![CDATA[Croatian Geological Survey]]></institution_en><team_members_id>5052, 6086, 13085, 3789, 12753, 866735, </team_members_id><team_members_names><![CDATA[Nikolina Ilijanić, Maja Briški, Vlatko Brčić, Andreja Sironić, Anica Benutić, Iva Palatinuš, ]]></team_members_names><keywords_hr><![CDATA[sige,stabilni izotopi,elementi u tragovima,U-Th i 14C metode datiranja,paleoklimatologija,holocen,Sjeverno-Atlantska oscilacija,Nova Grgosova spilja]]></keywords_hr><keywords_en><![CDATA[speleothems, stable isotopes, trace elements, U-Th and 14C dating, palaeoclimatology, Holocene, North Atlantic Oscillation, Nova Grgosova cave]]></keywords_en><summary_hr><![CDATA[Klimatske promjene jedan su od glavnih izazova s kojima se svijet danas suočava. Razumijevanje prirodne klimatske varijabilnosti predstavlja osnovnu informaciju za preciznije predviđanje budućih antropogeno uvjetovanih klimatskih promjena.Cilj UNLOCK-CAVE projekta je istražiti regionalni odgovor na visokofrekventnu prirodnu klimatsku varijabilnost u regiji Južne i Srednje Europe tijekom posljednjih 1400 godina koristeći geokemijske pokazatelje u sigama iz Nove Grgosove spilje u Hrvatskoj. Naši specifični ciljevi su: istražiti vezu geokemijskih značajki siga iz ove spilje i glavnog moda interne klimatske varijabilnosti, Sjeverno-Atlantske oscilacije (NAO) na godišnjoj do subdesetljetnoj vremenskoj rezoluciji; istražiti potencijal ovih siga za kvantitativne paleoklimatske rekonstrukcije te odgonetnuti klimatske i ne-klimatske uzroke odgovorne za izotopni sastav ugljika u ovim sigama. Paleoklimatske interpretacije će biti potpomognute dugogodišnjim, detaljnim monitoringom spilje. Ovaj projekt će rezultirati s prvim kvantitativnim podacima o klimatskim uvjetima u prošlosti na visokoj rezoluciji u ovoj slabo istraženoj regiji te će doprinijeti boljem razumijevanju regionalnog odgovora na promjene u atmosferskoj cirkulaciji u prošlosti.UNLOCK-CAVE projekt će okupiti šest mladih istraživača iz tri hrvatske institucije. Okupljanje ove istraživačke grupe će po prvi put omogućiti da se svi analitički kapaciteti trenutno dostupni u hrvatskim institucijama u potpunosti iskoriste za paleoklimatska istraživanja siga. Nadalje, u okviru ovog projekta planirano je uspostavljanje novih istraživačkih kapaciteta (npr. laboratorij za mikro-uzorkovanje i čista laboratorijska jedinica i uvođenje metode za pripremu uzoraka za U-Th datiranje). Ovo će potaknuti daljnja istraživanja u znanosti o sigama i ostalim geoznanstvenim disciplinama u Hrvatskoj, što će dovesti do poboljšanja cjelokupne kvalitete i znanstvenog utjecaja istraživanja provedenih na hrvatskim istraživačkim institucijama. ]]></summary_hr><summary_en><![CDATA[Climate change is one of the major challenges that the world is now facing. Understanding of natural past climate variability is crucial baseline information for more accurate predictions of anthropogenically-driven climate changes in the future. UNLOCK-CAVE project seeks to understand the regional response to high-frequency natural climate variability in South-Central Europe during the last 1400 years by exploring multiple geochemical proxies in speleothems from Nova Grgosova cave in Croatia. Our specific aims are: to explore the link between geochemical properties of speleothems at this site and a major mode of internal climate variability, North Atlantic Oscillation (NAO) on annual to sub-decadal time scale; to investigate potential of these speleothems to yield quantitative data on past climate variability and to decipher climate and non-climate drivers of carbon isotope composition in these speleothems. Our palaeoclimate interpretations will be underpinned by long-term extensive cave monitoring program. This project will yield first high-resolution quantitative record of past climate variability in this poorly studied region and will lead to a better understanding of regional responses to atmospheric circulation variability in the past.UNLOCK-CAVE project will gather six early career researchers from three Croatian institutions. The research group will, for the first time, enable that all analytical capabilities available at the Croatian institutions are fully exploited in speleothem based palaeoclimate research. Furthermore, establishment of new research facilities (e.g. microsampling and clean lab facility and implementation of a preparation method for U-Th dating) is planned within this project. This will stimulate further research in speleothem science and other geoscience disciplines in Croatia leading to an improvement in the overall quality and impact of research performed at Croatian research institutions.]]></summary_en></project><project>
<id>10103</id><title_hr><![CDATA[Hrvatske vrste roda Veronica: fitotaksonomija i biološka aktivnost]]></title_hr><title_en><![CDATA[Croatian Veronica species: Phytotaxonomy and Biological Activity]]></title_en><user_id>1317</user_id><user_firstLast_name>Valerija Dunkic</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2020-02</proposal_call><code>IP-2020-02-8425</code><acronim><![CDATA[CROVeS-PhyBA]]></acronim><duration>11.01.2021 - 10.05.2025</duration><status>Završio</status><financ_value>155.949,30 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Interdisciplinarne prirodne znanosti, Kemija, Biologija, </scie_field_hr><scie_field_en>Interdisciplinary natural sciences, Chemistry, Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Science]]></institution_en><team_members_id>2882, 5157, 19875, 24261, 24188, 4381, 5084, 372, 5082, 25207, </team_members_id><team_members_names><![CDATA[Marija  Nazlić, Elma Vuko, Jasna Puizina, Nenad Vuletić, Snježana Topić, Dario Kremer, Renata Jurišić Grubešić, Siniša Srečec, Mirko Ruščić, Ivana Vrca, ]]></team_members_names><keywords_hr><![CDATA[Veronica, slobodni hlapljivi spojevi, fenoli, molekularna filogenija, hidrolati, antioksidacija, antiproliferativnost,  genotoksičnost ]]></keywords_hr><keywords_en><![CDATA[Veronica, free volatile compounds, phenolic compounds, molecular phylogeny,  hydrolates, antioxidant,  antiproliferative, genotoxic activities]]></keywords_en><summary_hr><![CDATA[Komparativna fitokemijska istraživanja specijaliziranih biljnih metabolita ukazuju na blisku povezanost sistematike i fitokemije u taksonomiji biljnih vrsta. Rod Veronica pripadao je porodici Scrophulariaceae, a na osnovi molekularnih istraživanja premješten je u porodicu Plantaginaceae. Prema morfološkim značajkama podijeljen je u 13 podrodova. U Hrvatskoj su vrste roda Veronica rasprostranjene na raznolikim staništima i primjenjuju se u narodnoj medicini i prehrani, posebno ljekovita čestoslavica. Za ovaj rod dobro su istraženi vezani hlapljivi spojevi, iridoidni glikozidi, čija se distribucija podudara s nalazima molekularne filogenije. Istraživanja na projektu CROVeS-PhyBA temeljit će se na identifikaciji slobodnih hlapljivih spojeva i njihovoj distribuciji među odabranim vrstama roda Veronica. Glavni ciljevi projekta su: (1) Istraživanje mogućnosti korištenja slobodnih hlapljivih spojeva kao fitotaksonomskih markera i (2) Biološka aktivnost odabranih izolata. Specifični ciljevi su: (1) Sakupljanje odabranih biljaka roda Veronica uz praćenje okolišnih čimbenika svake lokacije; (2) Izolacija hlapljivih i fenolnih tvari iz odabranih vrsta i identifikacija fitokemijskog sastava; (3) Genetičke analize za precizniju identifikaciju sakupljenih biljnih vrsta. Usporedbom fitokemijskog rasporeda hlapljivih tvari među odabranim vrstama i njihove genetike, donijet će se zaključak o potencijalnim novim fitotaksonomskim markerima za rod Veronica; (4) Uzgoj odabranih čestoslavica u kontroliranim uvjetima, istraživanje njihovog fitokemijskog sastava te usporedba s rezultatima vrsta prirodnog staništa; (5) Istraživanje biološke aktivnosti izolata s prirodnog staništa i uzgojenih. Usporedbom rezultata donijet ćemo zaključak o potencijalnom korištenju ovih biljnih vrsta u farmakološke svrhe. Istraživanja će doprinijeti održivijem korištenju hrvatskih vrsta roda Veronica i njihovoj popularizaciji.]]></summary_hr><summary_en><![CDATA[Comparative phytochemical studies on the specialized metabolites have shown close association between systematics and phytochemistry in the taxonomy of the plant species. Genus Veronica belonged to the Scrophulariaceae family based on molecular researches it has been transferred to the Plantaginaceae family. It is divided into 13 subgenuses according to morphological features. In Croatia, species of the genus Veronica are spread over a variety of habitats and are used in folk medicine and nutrition, especially V. officinalis. For this genus bounded volatile compounds (VCs) - iridoid glycosides are well studied, whose distribution in genus Veronica coincides with the findings of molecular phylogeny. Research on the project CROVeS-PhyBA will be based on the identification of free VCs and their distribution among selected Veronica species. The results will be used for two main goals: (1) Conclusion on the possibility of using free volatile compounds as phytotaxonomic markers and (2) Biological activity of the isolates. Specific objectives are: (1) Collection of selected Veronica plants, with monitoring of environmental factors for each location; (2) Isolation of VCs and phenolic substances, identification of phytochemical composition; (3) Genetic analyses for more accurate identification of the collected species. By comparing phytochemical distribution of VCs and their genetics we will conclude on potential new phytotaxonomic markers for Veronica genus. (4) Cultivation of selected speedwells under controlled conditions, investigation of their phytochemical composition and comparison with results of species from natural habitat; (5) Biological activity of isolates of plants from natural habitats and cultivated. By comparing the results we will conclude on the potential use of these plants in pharmacology. The research will contribute to a more sustainable use of Croatian Veronica species and their popularization.]]></summary_en></project><project>
<id>10104</id><title_hr><![CDATA[Razvoj bioaktivnih molekula za tretman neurodegenerativnih bolesti]]></title_hr><title_en><![CDATA[Development of Bioactive Molecules for Neurodegenerative Diseases Treatment]]></title_en><user_id>991</user_id><user_firstLast_name>Anita Bosak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2020-02</proposal_call><code>IP-2020-02-9343</code><acronim><![CDATA[BioMol4ND]]></acronim><duration>01.01.2021 - 30.04.2025</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut za medicinska istraživanja i medicinu rada]]></institution_hr><institution_en><![CDATA[Institute for Medical Research and Occupational Health]]></institution_en><team_members_id>29180, 28972, 29229, 29188, 22504, 3033, 865028, </team_members_id><team_members_names><![CDATA[Dejan Opsenica, Ana Matošević, Sandra Šegan, Katarina Komatović, Antonio Zandona, Suzana Žunec, Marija Bartolić, ]]></team_members_names><keywords_hr><![CDATA[Alzheimerova bolest, inhibicija kolinesteraza, selektivnost prema BChE, karbamati, oksidativni stres, sinteza, BACE1]]></keywords_hr><keywords_en><![CDATA[Alzheimer&#39;s disease, cholinesterase inhibition, BChE selectivity, MTDL, carbamates, oxidative stress, synthesis, BACE1]]></keywords_en><summary_hr><![CDATA[Primarni cilj projekta je razvoj molekula koje mogu ublažiti simptome i usporiti napredovanje neurodegenerativnih bolesti (ND) koje utječu na neurone, primarno one u ljudskom mozgu, uzrokujući probleme s kretanjem i/ili mentalnim funkcioniranjem. Racionalno će se dizajnirati inhibitori kolinesteraza (ChE) koji se vežu u katalitičko i periferno mjesto aktivnog mjesta ChE, čime jedan spoj može istodobno utjecati na povećanje koncentracije acetilkolina u mozgu i inhibirati Abeta agregaciju. Spojevi sa zadovoljavajućim inhibicijom ChE kao primarnoj farmakofori, poslužili bi kao strukturne baze za MTDL (multi-target-directed-ligands) dizajn dodavanjem dodatnih farmakofora koje bi djelovale na druga obilježja demencije AD tipa (npr. oksidativni stres, homeostaza bimetala), što je primarni cilj projekta. Odredit će se sposobnost spojeva da inhibiraju BACE1 i Abeta agregaciju, prooksidativni/antioksidacijski kapacitet i citotoksičnost kako bi se utvrdila mogućnost njihove uporabe za liječenje ND. Razvoj tako dizajniranih spojeva imat će dva glavna smjera: razvoj CNS aktivnih i razvoj periferno aktivnih spojeva, ovisno o njihovoj sposobnosti prolaska krvno-moždane barijere. Razvoj MTDL lijekova koji istodobno djeluju na nekoliko obilježja AD je u prednosti prema razvoju lijekova koji djeluju na jedno od obilježja ND budući da osigurava dodatni farmakološki odgovor koji može sinergistički modulirati patološku kaskadu u neurodegeneraciji. Trenutno liječenje AD često je kombinacija postojećih lijekova ili uz dodatak onih koji djeluje na druga obilježja ND (npr. kelatori metala). Demencija AD tipa općenito pogađa ljude starije od 65 godina i upotreba velikog broja lijekova predstavlja teret za homeostazu organizma. S obzirom na veliki broj bolesnika koji će u budućnosti bit težak teret za javnozdravstveni sustav, lijekovi koji bi mogli ublažiti ili ukloniti simptome demencije, omogućujući pacijentima da u svakodnevnom životu budu neovisni o tuđoj pomoći, vrlo su potrebni.]]></summary_hr><summary_en><![CDATA[The primary goal of the project is to develop molecules with the potential to alleviate the symptoms and slow down the progression of neurodegenerative diseases (ND) that primarily affect the neurons in the human brain that causes problems with movement and/or mental functioning. The project aims to rationally design dual site binding cholinesterase (ChE) inhibitors (acting on improving the acetylcholine level in the brain and on Abeta aggregation) and use them as starting points for multi-target-directed ligand (MTDL) design by adding an additional pharmacophore in a single molecule entity able to act on other hallmarks of Alzheimer’s type of dementia (e.g. oxidative stress and bimetal dyshomeostasis). Compounds will be biologically evaluated (BACE1 and amyloid beta aggregation inhibition, pro-oxidant/antioxidant capacity, cytotoxicity, etc.) to determine their ability as possible drugs for treatment of ND. The development of these designed compounds will have two major objectives: development of CNS active and development of peripherally active compounds, depending on their ability to cross the blood-brain-barrier. In ND treatment, the development of multitargeted drugs is favourable compared to single-targeted drugs since an additional pharmacological response that might synergistically modulate the pathological cascade in neurodegeneration occurs. Moreover, current treatment of AD often combines currently available drugs, or of does so alongside an additional one acting on other hallmarks of ND (e.g. metal chelators). Considering that the AD type of dementia generally affects people ? 65, the use of a large number of drugs is a major burden for organism homeostasis. Considering the large number of patients that could bring a heavy burden to public health system in the future, the drugs that could alleviate or remove symptoms of dementia, allowing patients to be independent of the help from other people in daily life is very much needed.]]></summary_en></project><project>
<id>10109</id><title_hr><![CDATA[KONDICIONIRANJE MIKROBIOLOŠKI I KEMIJSKI ONEČIŠĆENIH VODA ELEKTROKEMIJSKIM I ULTRAZVUČNIM POSTUPCIMA]]></title_hr><title_en><![CDATA[PURIFICATION OF MICROBIOLOGICALLY AND CHEMICALLY CONTAMINATED DRINKING W ATER BY ELECTROCHEMICAL AND ULTRASONIC PROCESSES]]></title_en><user_id>22647</user_id><user_firstLast_name>Ivan Halkijević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2020-02</proposal_call><code>UIP-2020-02-1160</code><acronim><![CDATA[PRIMEUS]]></acronim><duration>11.01.2021 - 10.01.2026</duration><status>U tijeku</status><financ_value>250.451,79 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Građevinarstvo, Elektrotehnika, Kemijsko inženjerstvo, Interdisciplinarne tehničke znanosti, </scie_field_hr><scie_field_en>Civil engineering, Electrical engineering, Chemical engineering, Interdisciplinary technological sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Građevinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Civil Engineering]]></institution_en><team_members_id>6250, 17785, 864931, </team_members_id><team_members_names><![CDATA[Gordon Gilja, Domagoj Nakić, Katarina Licht, ]]></team_members_names><keywords_hr><![CDATA[elektrokoagulacija, ultrazvuk, šaržno kondicioniranje voda, protočno kondicioniranje voda, teški metali, mikrobiološko onečišćenje]]></keywords_hr><keywords_en><![CDATA[electrocoagulation, ultrasound, batch water purification, continuous water purification, heavy metals, microbiological contamination]]></keywords_en><summary_hr><![CDATA[Prema rezultatima monitoring vode za ljudsku potrošnju u Hrvatskoj iz 2018. godine većina uzoraka vode iz lokalnih (i individualnih) vodovoda bila je zdravstveno neispravna, primarno uslijed mikrobiološkog onečišćenja i povišenih koncentracija teških metala. Dezinfekcijom vode klorom ili klornim derivatima kao nusprodukti mogu nastati kancerogeni klorirani ugljikovodici te nitrozamini. Također, konvencionalni postupci uklanjanja teških metala, kao što su reverzna osmoza i ionska izmjena, su u pravilu tehnološki vrlo kompleksni i skupi. Sukladno recentnim istraživanjima napredne oksidacijske i elektrokemijske metode ukazuju na mogućnost učinkovitog uklanjanju različitih onečišćenja u procesu kondicioniranja voda. Stoga, svrha ovog projektnog prijedloga je utvrditi primjenjivost metode elektrokoagulacije te ultrazvuka, kao napredne oksidacijske metode, za uklanjanje mikrobiološkog onečišćenja i teških metala s primjenom na pitke vode. Konačni cilj projekta je izraditi uređaj malog kapaciteta za kondicioniranje vode kojim će se, na temelju provedenih projektnih istraživanja, definirati optimalna konfiguracija procesnih parametara elektrokoagulacije i ultrazvuka, kao i konstruktivnog oblikovanja uređaja, a kako bi se izradio uređaj protočnog karaktera. Nedostatak istraživanja protočnosti navedenih procesa jedan je od najvećih nedostataka postojećih istraživanja. Istraživanje će se provesti kroz pet faza u kojima će se uspostaviti istraživačka grupa i organizirati laboratorij, provesti laboratorijska istraživanja učinkovitosti elektrokoagulacije i ultrazvuka za uklanjanje onečišćenja pri različitim postavkama projektnih parametara. Zatim će se na temelju numeričkih modela utvrditi potrebno konstruktivno oblikovanje uređaja radi postizanja protočnosti, kao i utjecaj oblikovanja na učinkovitost, te izraditi sam uređaj temeljem provedenih istraživanja. Na koncu će se izvršiti optimizacija uređaja i izrada taložnika za uklanjanje elektrokoaguliranih flokula.]]></summary_hr><summary_en><![CDATA[According to the water quality monitoring for the human consumption in Croatia for 2018, most of the water from locaI (and individual) water supply systems were unsafe to drink, primarily due to the presence of microbiological and heavy metal contamination, Commonly used water disinfection process with chlorine and its compounds can produce carcinogenic byproducts, such as chlorinated hydrocarbons and nitrosamines. Also, conventional methods for removal of heavy metals, such as reverse osmosis and ion exchange, are very complex and expensive in general. According to the recent research, advanced oxidation and electrochemical processes show the possibility for efective removal of various pollutants in water purification process. Therefore, the purpose of this project proposal is to determine the applicability of the electrocoagulation (EC) and ultrasound (US), as an advanced oxidation process, for removing microbial and heavy metals contamination in drinking water preparation. The finaI goaI of the project proposal is to construct a small water purification system (EC and US reactor with settling tank) with optimum configuration defined on the project research, that will include different process parameters, as well as the design of the system, ln order to create a continuous water puriflcation system. The lack of the possibility for continuous treatment is one of the greatest shortcomings of the existing research. The research will undergo through five phases in which a research group and laboratory will be established and the EC and US efficiency for pollutants removal will be investigated for different process parameters. Then, through numerical modelling, the necessary design of the system elements will be defined in order to achieve the continuity of the purification process. Also, the effects of the system design on the removal efficiency will be investigated. Finally, the pollutants removal efficiency will be determined on the constructed and optimized system.]]></summary_en></project><project>
<id>10110</id><title_hr><![CDATA[EIKOSANOIDI IZVEDENI IZ DIJETE I FENOTIPI U SEPSI]]></title_hr><title_en><![CDATA[DIET-DERIVED EICOSANOIDS AND PHENOTYPES IN SEPSIS]]></title_en><user_id>29401</user_id><user_firstLast_name>Christian Reynolds</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2020-02</proposal_call><code>UIP-2020-02-2476</code><acronim><![CDATA[DDEPS]]></acronim><duration>02.05.2021 - 01.11.2026</duration><status>U tijeku</status><financ_value>246.469,44 eur</financ_value><scie_area_hr>Interdisciplinarno područje znanosti</scie_area_hr><scie_area_en>Interdisciplinary scientific area</scie_area_en><scie_field_hr>Biotehnologija u biomedicini, </scie_field_hr><scie_field_en>Biotechnology in Biomedicine, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Fakultet biotehnologije i razvoja lijekova]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Biotechnology and Drug Development]]></institution_en><team_members_id>29414, 865069, 869845, </team_members_id><team_members_names><![CDATA[Mari Rončević Filipović, Nada Birkić, Irma Markesina, ]]></team_members_names><keywords_hr><![CDATA[sepsa, polinezasićene masne kiseline, kardiovaskularni sustav, animalni model, klinička ispitivanja]]></keywords_hr><keywords_en><![CDATA[sepsis, polyunsaturated fatty acids, cardiovascular system, animal model, clinical studies ]]></keywords_en><summary_hr><![CDATA[Sepsa je ozbiljno zdravstveno stanje uzrokovano ozbiljnim sistemskim upalnim odgovorom na bakterijsku, gljivičnu ili virusnu infekciju. Sada je poznato da su protuupalni i vazoaktivni eikosanoidi endogeni kemijski signali koji orkestriraju reakciju na infekciju. Iako je uvaženo da eikosanoidi nastali kao odgovor na infekciju doprinose ishodima sepse, malo je studija pokušalo procijeniti korisnost upalnih lipidnih medijatora u stratifikaciji rizika. S obzirom na to da su eikosanoidi izvedeni iz polinezasićenih masnih kiselina koje sisavci dobivaju isključivo iz prehrambenih izvora, pretpostavljamo da prehrambene polinezasićene masne kiseline u prehrani mogu utjecati na reakcije na infekciju i / ili ishode sepse. Predložene studije podržat će razvoj nove multidisciplinarne istraživačke skupine na Sveučilištu u Rijeci koja će izvoditi i kliničke i translacijske studije. Projekt nastoji pružiti nove patofiziološke uvide i definirati ulogu prehrambenih polinezasićenih masnih kiselina u predviđanju ishoda u sepsi.]]></summary_hr><summary_en><![CDATA[Sepsis is a serious medical condition caused by a severe systemic inflammatory response to a bacterial, fungal, or viral infection. It is now appreciated that proinflammatory and vasoactive eicosanoids are endogenous chemical signals that orchestrate responses to infection. Although eicosanoids generated in response to infection are believed to contribute to outcomes in sepsis, few studies have attempted to evaluate the utility of inflammatory lipid mediators in risk-stratification. Given that eicosanoids are derived from polyunsaturated fatty acids, which mammals obtain exclusively from dietary sources, we hypothesize that dietary intake of polyunsaturated fatty acids may influences responses to infection and/or outcomes is sepsis. The current funding request will support the development of a new a multidisciplinary research group at the University of Rijeka that will perform both clinical and translational studies. The project seeks to provide novel pathophysiological insights and define the role of dietary polyunsaturated fatty acid content in predicting outcomes in sepsis. ]]></summary_en></project><project>
<id>10111</id><title_hr><![CDATA[Efekt kvantnog tuneliranja: dinamika molekula s kvantnim jezgrama]]></title_hr><title_en><![CDATA[Quantum tunnel effect: dynamics of molecules with quantum nuclei]]></title_en><user_id>3692</user_id><user_firstLast_name>Marko Tomislav Cvitaš</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2020-02</proposal_call><code>IP-2020-02-9932</code><acronim><![CDATA[QuanTunMol]]></acronim><duration>18.01.2021 - 17.06.2025</duration><status>Završio</status><financ_value>104.059,25 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>521, 2848, 854, 26197, 19680, 865264, </team_members_id><team_members_names><![CDATA[Ivan Ljubić, Nađa Došlić, Darko Babić, Mihael Eraković, Marin Sapunar, Nina Tokić, ]]></team_members_names><keywords_hr><![CDATA[instantoni, tuneliranjem uzrokovano cijepanje, metoda inegrala po stazama, kvantna molekulska dinamika, brzina tuneliranja]]></keywords_hr><keywords_en><![CDATA[instantons, tunnelling splitting, path-integral methods, quantum molecular dynamics, tunnelling rate]]></keywords_en><summary_hr><![CDATA[Kvantno tuneliranje igra važnu ulogu u molekulskoj dinamici i spektroskopiji, time što može znatno utjecati na reaktivnost i pregradnju molekula na načine koji bi inače bili zabranjeni. Instanton metoda pruža način da se aproksimira i vizualizira dinamika tuneliranja pomoću optimalnog puta tuneliranja duž kojeg se kvantni proces dominantno odvija. Oslanja se na optimizaciju putanje i time omogućava primjenu na mnogo većim molekulskim sustavima u punoj dimenzionalnosti nego što je to dostupno preciznijim metodama. Cilj ovog projekta je proširiti domenu primjenjivosti instanton metode i povećati njenu efikasnost kako bi se njome mogao proučavati širi spektar sustava. Naš je cilj da razvijemo novu instanton teoriju za računanje cijepanja vibracijski pobuđenih stanja uslijed tuneliranja kao i za račun rotacijskih energija. Te teorije namjeravamo primijeniti na spektre grozdova vode koji su nedavno mjereni, što će testirati potencijale vode na geometrijama koje su daleko od ravnotežnih i pružati uvid u dinamiku vodikovih veza, kako se one cijepaju, stvaraju i pregrađuju. U daljnjoj primjeni predviđamo proučavanje efekta supstitucije na vodikovu vezu kod nekih dimera supstituiranih karboksilnih kiselina kroz cijepanje uslijed tuneliranja. Također, cilj nam je razviti metode za efikasan pronalazak optimalnih puteva tuneliranja u računima brzine reakcije. Te metode primijenit ćemo na proučavanje fotoinducirane neadijabatske dinamike u elektronski pobuđenim stanjima, npr. indola ili fenola, kako bi interpretirali vremenski ovisne fotoelektronske spektre koristeći kombinaciju dinamike skokova među stanjima (FSSH) iznad barijere za disocijaciju vodika, te koristeći instantone za određivanje brzine tuneliranja ispod barijere za disocijaciju. Konačno, primijenit ćemo naše metode za izračun brzine tuneliranja za odabrane reakcije slobodnih radikala u vodenim otopinama kako bi odredili njihove mehanizme i kinetički izotopni efekt.]]></summary_hr><summary_en><![CDATA[Quantum tunnelling plays an important role in dynamics and spectroscopy of molecules. It can significantly affect reactivity and allow molecular rearrangements which would otherwise be forbidden. Instanton method provides a way to approximate and visualise tunnelling dynamics using an optimal tunnelling path along which the quantum process predominantly take place.  It relies on the optimization of the path, thus it enables us to treat much larger molecular systems in full dimensionality or rely on more accurate on-the-fly electronic potentials than the more accurate methods. The aim of this project is to extend the domain of applicability of the instanton method and to increase its efficiency in order to study systems that would otherwise be inaccessible. Specifically, we aim to develop a new instanton theory to calculate tunnelling splittings in vibrationally excited states and rotational energies. We will apply those theories to study tunnelling spectra in water clusters that have recently been measured, which will provide tests of water potentials at far-from-equilibrium geometries and insights into dynamics of hydrogen bonds, how they break, form and rearrange. Further applications envisage the study of the substituent effect on hydrogen bonds in some substituted carboxylic acid dimers through the associated tunnelling splittings. We also aim to develop methods for efficiently locating optimal tunnelling paths for rate calculations in nonadiabatic systems. These will be applied to study photo-excited nonadiabatic dynamics of indole or phenol and interpret time-resolved photoelectron spectra using a combination of surface-hopping dynamics above the H atom detachment barrier and instantons for the dissociation rates below the barrier. Finally, we will apply our methods to calculate tunnelling rates for selected free radical reactions which take place in aqueous solutions to determine mechanisms and estimate kinetic isotope effect.]]></summary_en></project><project>
<id>10117</id><title_hr><![CDATA[Karakterizacija i monitoring rasjednog sustava šireg dubrovačkog područja]]></title_hr><title_en><![CDATA[Characterization and monitoring of the Dubrovnik fault system]]></title_en><user_id>199</user_id><user_firstLast_name>Josip Stipčević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2020-02</proposal_call><code>IP-2020-02-3960</code><acronim><![CDATA[DuFAULT]]></acronim><duration>15.02.2021 - 14.02.2025</duration><status>Završio</status><financ_value>181.259,54 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Geofizika, Geologija, </scie_field_hr><scie_field_en>Geophysics, Geology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>29661, 26662, 37, 39, 208, 7702, 858437, 864925, 26762, 869797, </team_members_id><team_members_names><![CDATA[Tena Belinić Belinić, Marija Mustać, Marijan Herak, Davorka Herak, Iva Dasović, Bruno Tomljenović, Helena Latečki, Snježana Cvijić Amulić, Marin Sečanj, Ivana Zonjić, ]]></team_members_names><keywords_hr><![CDATA[Dubrovnik, potres, rasjed, modeliranje, građa Zemljine kore]]></keywords_hr><keywords_en><![CDATA[Dubrovnik, earthquake, fault, modelling, crustal structure]]></keywords_en><summary_hr><![CDATA[Hrvatska, a posebice njen južni dio nalazi se na potresno aktivnom prostoru kojeg, u usporedbi s velikim dijelom Europe, karakterizira visoka stopa seizmičnosti. Prema hrvatskom katalogu potresa na ovom području se dogodilo mnogo jakih potresa od kojih je posebice razoran bio veliki dubrovački potres iz 17. stoljeća. Dobro poznavanje građe kore i precizna lokacija žarišta potresa imaju ključnu ulogu u određivanju aktivnih rasjeda, a time i procjeni seizmičkog hazarda. Ove komponente do sada nisu bile određene na zadovoljavajući način za jugoistočni dio Jadrana ponajprije zbog nepovoljnog rasporeda i malog broja seizmoloških postaja na tom području. U ovom projektnom prijedlogu, naš glavni cilj je procjeniti seizmogeni potencijal te okarakterizirati promjenu stanja rasjednog sustava šireg dubrovačkog područja na temelju novo prikupljenih podatka uz upotrebu modernih geofizičkih metoda. Da bismo ispunili navedene ciljeve prikupit ćemo skup visoko kvalitetnih seizmološki podataka kroz uspostavu privremene mreže seizmoloških postaja povezujući novo instalirane postaje s već postojećima iz nekoliko nacionalnih seizmografskih mreža u okolici. Uz upotrebu novo prikupljenih podataka te primjenu i unaprijeđenje modernih seizmoloških metoda planiramo odrediti 3D strukturu kore, mapirati rasjedni sustav, poboljšati praćenje seizmičnosti te odrediti ulogu dubrovačkog rasjednog sustava unutar šire slike tektonskih procesa u Mediteranu. Novi uvid u seizmičnost, građu litosfere i tektonske procese u široj dubrovačkoj regiji omogućit će da simuliramo realni scenarij velikog potresa te rasprostiranje potresnih valova na tom području što će u konačnici pridonijeti boljoj procjeni seizmičkog hazarda. Takvi seizmološki rezultati u kombinaciji s LIDAR mapiranjem, batimetrijom, geološkim i geodetskim istraživanjima, koja se već provode ili su planirana u skoroj budućnosti, omogućit će jedinstveni uvid u geodinamiku i karakter rasjednog sustava u ovoj regiji sklonoj potresima.]]></summary_hr><summary_en><![CDATA[Croatia and especially its southern part is located in a seismically very active region characterized by relatively high earthquake rates when compared to the rest of Europe. The historical seismicity catalogue for this region includes numerous strong events, with the 17th century Dubrovnik earthquake being particularly significant. Detailed knowledge about the upper crustal structure and seismicity pattern is crucial for e.g. hazard modelling and for south-eastern Adriatic, these are still missing, mostly due to unfavourable spatial layout and insufficient density of seismic stations in the area. In this project proposal, our main aim is to assess the seismogenic potential of the Dubrovnik fault system and the fault behaviour by collecting new high-resolution seismic data, applying and improving the most recent geophysical methods. In order to fulfil our objectives, we will collect new and high-quality seismic data by establishing a semi-permanent observatory to complement the existing network. By using the new data and by applying and improving existing methods, we aim to assess in much greater detail than previously possible the 3D crustal structure, the seismicity, fault system anatomy, tectonic stress accumulation rate, and the physics of the lithospheric forces within the dynamic broad picture of the Mediterranean tectonic processes. These new insights will allow for the development of a detailed 3D model of the crust that would in return enable 3D simulations of wave propagation and local seismic hazard assessment. Such seismological results, combined with e.g. geological data, LIDAR mapping, bathymetry, or geodetic (GPS and InSAR) investigations – all of which are either on-going in Croatia, or are planned for the near future – will be fundamental for studies of geodynamics as well as for characterization of active faults in this earthquake-prone area.]]></summary_en></project><project>
<id>10118</id><title_hr><![CDATA[ Važnost mehanokemijske reaktivnosti u prebiotičkoj kemijskoj evoluciji i njezin prijenos na održivu kemijsku proizvodnju s niskim emisijama]]></title_hr><title_en><![CDATA[The relevance of mechanochemical reactivity in the prebiotic chemical evolution and its transfer to sustainable and low-emission chemical production]]></title_en><user_id>280</user_id><user_firstLast_name>Krunoslav Užarević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2020-02</proposal_call><code>IP-2020-02-4702</code><acronim><![CDATA[PREBIOMECHEM]]></acronim><duration>01.02.2021 - 31.01.2025</duration><status>Završio</status><financ_value>199.044,40 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, Interdisciplinarne prirodne znanosti, </scie_field_hr><scie_field_en>Chemistry, Interdisciplinary natural sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>29530, 24360, 23293, 25668, 21300, 24767, 865409, 88, 870047, </team_members_id><team_members_names><![CDATA[Valentina Martinez, Tomislav Stolar, Bahar Karadeniz, Tomislav Mrla, Natalija Pantalon Juraj, Jasna Alić, Ivana Brekalo, Aleksandar Sabljić, Emilija Petrović Hađar, ]]></team_members_names><keywords_hr><![CDATA[Prebiotska kemija, mehanokemija, kemijska evolucija, biomolekule, porijeklo života, in-situ praćenje, suvremena održiva kemijska proizvodnja]]></keywords_hr><keywords_en><![CDATA[Prebiotic chemistry, mechanochemistry, chemical evolution, biomolecules, origins of life, in-situ monitoring,  modern sustainable chemical production]]></keywords_en><summary_hr><![CDATA[Projektni prijedlog je usmjeren na istraživanje mehanokemije kao sintetske alternative za  nastanak važnih biomolekula poput aminokiselina, šećera, nukleotida i nukleozida u prebiotskoj kemijskoj evoluciji. Projekt će se posebno fokusirati na kemijske reakcije koje izazivaju polemiku među znanstvenicima uključenima u istraživanje porijekla života i prebiotske evolucije, a to su reakcije koje su termodinamički nepovoljne u otopinama, poput nastanka peptida, kompleksnijih saharida, nukleozida ili dijelova lanaca nukleobaza, te kod kojih su prebiotski prihvatljivi reaktanti teško topljivi, kao što je slučaj s reakcijama fosforilacije. Mehanokemijske metode koje će se koristiti će biti mljevenje u kugličnim mlinovima, uz dodatke prebiotski prihvatljivih minerala kao katalizatora i potencijalno malih količina vode ili otopina soli. Dodatno, ispitat će se mehanokemijski procesi nastali mljevenjem uz električne izboje visokog napona, za koje će se izgraditi specijalizirani  i jedinstven reaktor. U ovim reakcijama, svojevrsnim proširenjem Miller-Urey eksperimenta (Science, 1953, 528), ispitat će se djelovanje mehaničke sile na plinovite reaktante (jednostavne plinove) ili jednostavne organske molekule na površinama minerala (dodani kao katalizatori), uz visokonaponski električni izboj i svjetlosno ozračivanje. Planirane reakcije će se pratiti in situ tehnikama praćenja poput Ramanove spektroskopije i difrakcije sinkrotronskog zračenja na polikristalnom uzorku, te novo-razvijenih tehnika poput spektroskopije elektronskog spina ili infracrvene spektroskopije. Na temelju stečenih znanja o efektu mineralnih aditiva i mehanokemije na sintezu važnih biomolekula, stečeno znanje će se primijeniti na razvoj zelene sinteze vrijednih kemijskih spojeva, te skaliranje sinteze na gram ili pilot skalu.]]></summary_hr><summary_en><![CDATA[The project proposal focuses on the research of mechanochemistry as a synthetic alternative for the formation of important biomolecules such as amino acids, sugars, nucleotides, and nucleosides in prebiotic chemical evolution. The project will focus specifically on the chemical reactions that cause controversy among scientists involved in the study of the origin of life and prebiotic evolution; for example, reactions that are thermodynamically unfavorable in solution, such as polymerization of amino acids to peptides, synthesis of complex saccharides, nucleosides, or nucleotides. Also, we will study the reactions where the acceptable prebiotic reactants are insoluble, as is the case with phosphorylation reactions. We will mainly use milling in ball mills, with the addition of adequate prebiotic minerals as catalysts and potentially small amounts of water or dissolved salts. Additionally, the mechanochemical processes generated by milling with high-voltage electrical discharges will be examined, for which a specialized and unique reactor will be built. In these reactions, which may be considered as an extension of the Miller-Urey experiment (Science, 1953, 528), we will study the effect of mechanical forces on gaseous reactions (simple gases) or simple organic molecules on the surface of minerals (added as catalysts), with high-voltage electrical devices and light irradiation.The planned reactions will be monitored in situ by established techniques such as Raman spectroscopy and diffraction on polycrystalline samples during milling, and also by newly developed techniques such as electron spin spectroscopy or infrared spectroscopy. Based on the acquired knowledge of the effect of mineral additives and irradiation for the mechanochemical synthesis of essential biomolecules, the acquired knowledge will be applied to the development of the green synthesis of chosen valuable chemical compounds, scaled to gram- or pilot scale.]]></summary_en></project><project>
<id>10124</id><title_hr><![CDATA[Molekularne životne strategije fitoplanktona u Jadranu]]></title_hr><title_en><![CDATA[The molecular life strategies of the Adriatic Sea Phytoplankton]]></title_en><user_id>4424</user_id><user_firstLast_name>Daniela Maric Pfannkuchen</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2020-02</proposal_call><code>UIP-2020-02-7868</code><acronim><![CDATA[Adri LIFE]]></acronim><duration>01.03.2021 - 28.02.2026</duration><status>U tijeku</status><financ_value>262.592,08 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Interdisciplinarne prirodne znanosti, Biologija, </scie_field_hr><scie_field_en>Interdisciplinary natural sciences, Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>390, 543, 25883, 21415, 547, 2979, 865150, 866487, </team_members_id><team_members_names><![CDATA[Ana Baričević, Mirta Smodlaka Tanković, Ivna Vrana Špoljarić, Nataša Kužat, Emina Pustijanac, Ana Car, Mia Knjaz, Ivan Vlašiček, ]]></team_members_names><keywords_hr><![CDATA[fitoplankton, Jadransko more, metatranskriptom, ekologija, ekofiziologija, sukcesija fitoplanktona]]></keywords_hr><keywords_en><![CDATA[phytoplankton, Adriatic Sea, metatranscriptom, ecology, ecophysiology, phytoplankton succession]]></keywords_en><summary_hr><![CDATA[Fitoplankton ima iznimno važnu ulogu u biogeokemijskim ciklusima ekosustava mora. Raznolikost i fiziološke prilagodbe fitoplanktona utječu na bioraznolikost, dinamiku i međuodnose u mreži morskog ekosustava. Naši dosadašnji rezultati ukazuju da fitoplankton pokazuje širok raspon prilagodbi, a osobitosti kojih su razlučive na razini vrste/soja. Fiziološke prilagodbe određuju prostorno-vremensku izmjenu i zastupljenost vrsta unutar fitoplanktonske zajednice te elastičnost zajednice na promjene okoliša. Cilj ovog projekta je detaljno istražiti dinamiku fitoplanktona u godišnjim ciklusima praćenjem sastava i fizioloških karakteristika zajednice. Uz klasičan pristup taksonomske identifikacije i fizioloških mjerenja, primijenit ćemo i napredne molekularne metode temeljene na sekvenciranju nove generacije barkoda i transkriptoma. Da bi bolje razumjeli fiziološke prilagodbe fitoplanktona na specifične uvjete okoliša, te poboljšali taksonomsku rezoluciju metatranskriptomskih analiza, ovaj projekt usporedno in situ mjerenjima razvija i  novi pristup u kojem se ključne vrste iz okoliša izoliraju u monoklonalne kulture te podvrgavaju ograničenju hranjivim tvarima čime će se dobiti fiziološki odgovori (referentna baza transkriptoma i expresija gena kao odgovor na resurse) ciljanih vrsta na ciljane uvjete. Sjeverni Jadran kao područje istraživanja pokazuje tijekom godine izražen ekološki gradijent te time predstavlja idealan morski ekosustav za promatranje fitoplanktona/transkriptoma u različitim uvjetima. U planirana istraživanja će se uključiti i južni dio jer će to omogućiti usporedbu fitoplanktonskih zajednica dva povezana, ali različita područja Jadrana. Očekivani rezultati omogućiti će testiranje i karakterizaciju predložene kompartmentalizacije niša u ekologiji fitoplanktona. Ovaj projekt omogućit će dublje razumijevanje fiziologije i prilagodbi fitoplanktona te će dodatno osvijetliti složene i osjetljive životne strategije ključnih vrsta.]]></summary_hr><summary_en><![CDATA[Phytoplankton plays a key role in marine biogeochemical cycles. Physiological adaptations of phytoplankton affect biodiversity, dynamics and interactions in marine ecosystem networks. Our earlier results indicate a wide range of ecophysiological adaptations that are unconstrained and differentiated at species/lineage level. Physiological adaptations determine the spatial-temporal dynamics in phytoplankton but also resilience of the community to environmental changes. The main objective of this project is a detailed investigation of marine phytoplankton dynamics through its yearly cycles by following composition and physiological characteristics of the community. Next to classical approaches of taxonomic identification and physiology measurements, we will implement high-throughput molecular methods based on next generation sequencing of barcodes and transpcritomes. To better understand physiological responses of phytoplankton species and improve taxonomic resolution of metatranscriptome analyses, this project will isolate key species from environmental samples are isolated in into monoclonal cultures and subject them to nutrient limitations. This approach will result in a valuable dataset of physiological responses (transcriptome reference database and resource responsive gene expression) of targeted (key) species to targeted (key) conditions. The Northern Adriatic offers marked ecological gradients and represents an ideal ecosystem to observe phytoplankton/transcriptomes under different ecological challenges. Inclusion of the South Adriatic will gieve a wider aspect and allows comparisons between two connected but diverse environments. The expected results will allow this project to test and characterize the hypothesized niche compartmentalization in plankton ecology. This project further will allow a deeper understanding of the physiological pathways and adaptations of phytoplankton and will furthermore shed light on the complex life strategies of key species.]]></summary_en></project><project>
<id>10125</id><title_hr><![CDATA[Međugeneracijski prijenos rizika za mentalno zdravlje adolescenata]]></title_hr><title_en><![CDATA[Intergenerational risk transmission for adolescent mental health]]></title_en><user_id>13038</user_id><user_firstLast_name>Marina Ajduković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2020-02</proposal_call><code>IP-2020-02-5967</code><acronim><![CDATA[INTRAD]]></acronim><duration>01.03.2021 - 28.06.2025</duration><status>Završio</status><financ_value>89.954,41 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Socijalne djelatnosti, </scie_field_hr><scie_field_en>Social work, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Pravni fakultet u Zagrebu]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Law]]></institution_en><team_members_id>13253, 7769, 29324, 29326, 12853, 12879, 12956, 29400, 12881, 24348, 19170, 18962, 866661, </team_members_id><team_members_names><![CDATA[Ivan Rimac, Gordana Keresteš, Tanja Jovanovic, Trudy Mooren, Jelena Ogresta, Linda Rajhvajn Bulat, Miroslav Rajter, Marina Štambuk, Nika Sušac, Petra Kožljan, Jure Krasić, Ines Rezo, Luka Stanić, ]]></team_members_names><keywords_hr><![CDATA[mentalno zdravlje, ratna iskustva, nepovoljni životni događaji, stres, zaštitni čimbenici, roditeljstvo, adolescenti]]></keywords_hr><keywords_en><![CDATA[mental health, war experiences, adverse life experiences, stress, protective factors, parenting, adolescents]]></keywords_en><summary_hr><![CDATA[Svrha projekta je pridonijeti boljem razumijevanju povezanosti mentalnog zdravlja roditelja i djece te istražiti međugeneracijski prijenos učinaka ratnih iskustava i nepovoljnih životnih događaja na roditeljstvo i mentalno zdravlje roditelja i adolescenata. Istraživanje se zasniva na kombiniranom metodološkom pristupu u kojem se koristi eksplanatorni sekvencijalni nacrt koji počinje kvantitativnim (anketnim) istraživanjem, nakon kojeg slijedi epigenetsko i kvalitativno istraživanja. U anketnom istraživanju koristit će se ciljani uzorak 1000 učenika 1. razreda srednje škole i 2000 njihovih roditelja iz Sisačko-moslavačke, Karlovačke i Brodsko-posavske županije, područja pogođenih ratnim stradanjima tijekom Domovinskog rata. Glavni konstrukti su operacionalizirani kroz sljedeće varijable: traumatsko iskustvo prije, za vrijeme i nakon rata; broj stresnih događaja i doživljaj svakodnevnog stresa roditelja; roditeljski stres; mentalno zdravlje roditelja; značajke roditeljstva kroz roditeljske stilove, parentifikaciju djece, nasilje nad djecom u obitelji; mentalno zdravlje adolescenata kroz izraženost internaliziranih problema, eksternaliziranih problema i ostalih rizičnih ponašanja. Za sudjelovanje u epigenetskom dijelu istraživanja korištenjem jednostavne i bezbolne metode brisa unutrašnje strane obraza bit će odabrano 120 obitelji prema nacrtu 2 X 2 - ratna trauma roditelja (ima/nema) i status mentalnog zdravlja roditelja (visoko rizični/nisko rizični). Od ovog uzorka će se odabrati 30 parova roditelja koji su doživjeli nepovoljne događaje za kvalitativni dio istraživanja. Spoznaje će biti značajne za planiranje ciljanih mentalno-zdravstvenih usluga za različite dobne skupine. Istraživačku grupu od 13 članova s bogatim iskustvom provođenja kvantitativnih i kvalitativnih istraživanja i povezanih s temom projekta vodi prof.dr. Marine Ajduković. Proračun projekta je 764.600,00 kn.]]></summary_hr><summary_en><![CDATA[The aim of this project is to contribute to a better understanding of the relationship between the mental health of parents and offspring, specifically to a better understanding of the intergenerational transmission of the effects of war experiences and adverse life events on parenting and the mental health of parents and adolescents. An explanatory sequential research design will be used in this study, based on a combined approach, beginning with the collection and analysis of quantitative survey data and following with the implementation of the epigenetic and qualitative study. Sample of 1000 first-year secondary school pupils and their 2000 parents will be selected according to the location of the pupil’s school, in Sisak-Moslavina, Karlovac and Brod-Posavina counties, which were particularly affected by war events during the Croatian War of Independence. The main constructs are: parents’ traumatic experience before, during and after the war; the number of stressful events, the experience of daily and parenting stress; parents’ mental health; parenting styles, parentification of children and family violence against children; adolescent mental health - internalizing problems, externalizing problems and risk behaviours. 120 families will participate in the epigenetic part of the study, using a simple and painless method of swabbing the inside of the mouth, for which a 2X2 research design will be used: parental war trauma (yes/no) and parental mental health status (high risk/low risk). 30 pairs of parents will be selected for the qualitative study, based on their experiences of adverse life events. The results of this project will make a valuable contribution to the planning of social and mental health services. The research group consists of 13 researchers with extensive experience in conducting quantitative and qualitative research related to the topic of the project led by Professor Marina Ajduković as the principal investigator. Project budget is €102.878,00.]]></summary_en></project><project>
<id>10127</id><title_hr><![CDATA[Procjena seizmičkog rizika građevina kulturne baštine u Hrvatskoj]]></title_hr><title_en><![CDATA[Seismic risk assessment of cultural heritage buildings in Croatia]]></title_en><user_id>40</user_id><user_firstLast_name>Snježana Markušić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2020-02</proposal_call><code>IP-2020-02-3531</code><acronim><![CDATA[SeisRICHerCRO]]></acronim><duration>25.01.2021 - 24.01.2025</duration><status>Završio</status><financ_value>148.238,10 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Geofizika, Geologija, </scie_field_hr><scie_field_en>Geophysics, Geology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>25746, 25747, 281, 3063, 29108, 13721, 23961, 29379, 282, 25754, 26139, 29298, 865203, 866647, 866648, </team_members_id><team_members_names><![CDATA[Davor Stanko, Mario Gazdek, Ines Ivančić, Davorin Penava, Kristina Šariri, Tvrtko Korbar, Abrahamczyk Lars, Sinan Akkar, Ivica Sović, Radmila Salic, Zeynep Gulerce, Vasilis Sarhosis, Iva Lončar Lončar, Bruno Mravlja, Valentina Dervišević, ]]></team_members_names><keywords_hr><![CDATA[potresi, seizmičnost, seizmički rizik, Hrvatska, kulturna baština]]></keywords_hr><keywords_en><![CDATA[earthquakes, seismicity, seismic risk, Croatia, cultural heritage]]></keywords_en><summary_hr><![CDATA[Veliki broj potencijalno ranjivih konstrukcija se nalazi na potencijalno seizmički ugroženim područjima, pri čemu su ekonomski resursi za njihovu zaštitu daleko od adekvatnih. Zato procjena rizika postaje strateški alat kada je nužno odrediti prioritete za slučaj obnove. Ovaj aspekt postaje jako važan kada se radi o objektima kulturne baštine. U Hrvatskoj su seizmički najaktivnija područja: obalni dio i sjeverozapadna kontinentalna Hrvatska. Povijesni podaci potvrđuju kako se na dubrovačkom području dogodilo više jakih potresa, a u kontinentalnom dijelu zabilježeni su jaki potresi u okolici Zagreba te planina Ivanščica i Kalnik. Stoga bi nužno bilo istražiti, kao “case-study”, karakteristične građevine i skupine objekata kulturne baštine, te razviti postupak procjene seizmičkog rizika, koji bi bio primijenjiv i na druge slučajeve. Kriterij za odabir karakterističnih objekata je da se nalaze na području izražene seizmičnosti (time i najvećeg seizmičkog hazarda), pa su tako odabrani: stara gradska jezgra Dubrovnika (obuhvaća mnoštvo crkava, samostana, Knežev dvor, palaču Sponzu, sve dubrovačke muzeje), katedrala sv. Jakova u Šibeniku (najznačajnije arhitektonsko ostvarenje 15. i 16. stoljeća u Hrvatskoj), te dvorac Trakošćan (jedan od najatraktivnijih hrvatskih dvoraca). Prve dvije lokacije se nalaze i na UNESCO-vu popisu svjetske baštine. Na osnovu kvantitativne i kvalitativne analize spomenutih monumentalnih građevina i lokacija, primarni cilj predloženog istraživanja je razvijanje jednostavne i jasno primjenjive metodologije te praktičnog postupka za procjenu seizmičkog rizika objekata kulturne baštine s ciljem jačanja otporne infrastrukture, koji uključuje makro (procjena na gradskoj skali – slučaj stare jezgre Dubrovnika) i mikro (procjena pojedinih objekata – katedrala u Šibeniku i dvorac Trakošćan) pristup. Oba pristupa omogućit će procjenu scenarija oštećenja, te ekonomskih i ljudskih gubitaka. ]]></summary_hr><summary_en><![CDATA[In many seismic prone areas there is an unsustainable amount of vulnerable constructions and economic resources are far to be adequate to protect them all. Thus, the risk assessment becomes a strategic tool for each community to establish priorities when planning construction retrofitting. This aspect becomes very important when the goods exposed to the risk are un-replaceable as in the case of cultural heritage. The most earthquake prone areas in Croatia are the coastal and the northwestern continental parts of Croatia. The earthquakecatalogue shows that Dubrovnik area was repeatedly hit by strong earthquakes, while in the continental part of Croatia are reported strong earthquakes around Zagreb and Ivanščica-Kalnik Mts. Therefore, it is considered as necessary to investigate selected cultural heritage buildings, and to develop a seismic risk assessment procedure that would be applicable to other cases of interest. Characteristic locations were selected according to the highest level of seismicity criteria. As a target locations are chosen the old city center of Dubrovnik (comprising a multitude of churches, monastries, palaces, etc.), the most significant architectural achievement of the 15th and 16th centuries in Croatia – the cathedral St. Jakov in Šibenik, and one of the most attractive castles in Croatia - Trakošćan Castle. The first two sites are on the UNESCO World Heritage list. Based on the quantitative and qualitative analyses of listed monumental buildings and locations, the primary objective of the proposed research is development of ready transferable methodology and practical procedure for assessing the seismic risk of cultural heritage which include seismic risk assessments on urban scale (macro approach) – case of Dubrovnik old city center, and for individual monuments (micro approach) – cases of cathedral in Šibenik and Trakošćan castle. Both approaches will allow estimation of physical damage scenarios, economical and ethic losses. ]]></summary_en></project><project>
<id>10129</id><title_hr><![CDATA[Algoritamske konstrukcije kombinatornih objekata]]></title_hr><title_en><![CDATA[Algorithmic Constructions of Combinatorial Objects]]></title_en><user_id>5935</user_id><user_firstLast_name>Vedran Krčadinac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2020-02</proposal_call><code>IP-2020-02-9752</code><acronim><![CDATA[ACCO]]></acronim><duration>01.01.2021 - 31.12.2024</duration><status>Završio</status><financ_value>108.602,80 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>5381, 4484, 4992, 17780, 865314, 866617, </team_members_id><team_members_names><![CDATA[Mario Osvin Pavčević, Anamari Nakić, Kristijan Tabak, Renata Vlahović Kruc, Filip Martinović, Lucija Relić, ]]></team_members_names><keywords_hr><![CDATA[kombinatorna konstrukcija, algoritam, dizajn, dizajn nad konačnim poljem, parcijalni linearni prostor, jako regularni graf, diferencijski skup]]></keywords_hr><keywords_en><![CDATA[combinatorial construction, algorithm, design, design over finite field, partial linear space, strongly regular graph, difference set]]></keywords_en><summary_hr><![CDATA[Ovaj projektni prijedlog spada u područje konstrukcija kombinatornih objekata s pomoću računala. U fokusu će biti konstrukcije objekata s dodatnom algebarskom strukturom kao što su shematski dizajni, q-analogoni dizajna, mozaici dizajna, kocke dizajna, (polu)parcijalne geometrije i generalizacije. Rezultati iz algebarske kombinatorike postavljaju ograničenja na parametre i svojstva takvih objekata koja se mogu iskoristiti da bi se suzilo prostor pretraživanja i razvili specijalizirani algoritmi za njihovu konstrukciju i klasifikaciju.Glavni ciljevi projekta su razvoj algoritamskih metoda konstrukcije i klasifikacije kombinatorinih objekata s dodatnom algebarskom strukturom i proširivanje teorijskih znanja o takvim objektima. Razvit ćemo softverski paket, implementiran u sustavu za računalnu algebru GAP, za konstrukciju i analizu kombinatornih objekata.]]></summary_hr><summary_en><![CDATA[The proposed project falls into the area of combinatorial constructions of objects with the aid of computers. We will focus on the construction of objects with additional algebraic structure such as schematic designs, q-analogs of designs, mosaics of designs, design cubes, (semi)partial geometries and generalisations. Results in algebraic combinatorics impose restrictions on the parameters and properties of such objects that can be exploited to narrow-down the search space and develop specialised algorithms for their construction and classification.The main objectives of the proposed project are development of algorithmic methods for the construction and classification of combinatorial objects with strong algebraic structure and widening of theoretical knowledge about such objects. We will develop of a software package, implemented in the computer algebra system GAP,for the construction and analysis of combinatorial objects.]]></summary_en></project><project>
<id>10130</id><title_hr><![CDATA[Interkalirani Dihalkogenidi Prijelaznih Metala]]></title_hr><title_en><![CDATA[Intercalated Transition Metal Dichalcogenides ]]></title_en><user_id>3247</user_id><user_firstLast_name>Petar Popčević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2020-02</proposal_call><code>IP-2020-02-9666</code><acronim><![CDATA[iTMD]]></acronim><duration>01.02.2021 - 30.06.2025</duration><status>Završio</status><financ_value>183.728,18 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut za fiziku]]></institution_hr><institution_en><![CDATA[Institute of Physics in Zagreb]]></institution_en><team_members_id>3018, 11197, 4754, 3420, 26812, 4367, 865337, 28808, 866683, 1173, </team_members_id><team_members_names><![CDATA[Ana Smontara, Mirta Herak, László Forró, Ivo Batistić, Naveen Kumar Chogondahalli Muniraju, Marija ZORIĆ, Gaurav Pransu, Naveen Singh  Dhami, Wojciech Sas, Mario Novak, ]]></team_members_names><keywords_hr><![CDATA[dihalkogenidi prijelaznih metala, interkalacija, magnetska uređenja, frustracija, nered, topološka stanja, uniaksijalni tlak]]></keywords_hr><keywords_en><![CDATA[transition metal dichalcogenides, intercalation, magnetic orderings, frustration, disorder, topological states, uniaxial pressure]]></keywords_en><summary_hr><![CDATA[Ovaj projektni prijedlog baziran je na dihalkogenidima prijelaznih metala (TMD). Oni su porodica slojevitih (kvazi dvodimenzionalnih) materijala koji uslijed reducirane dimenzionalnosti pokazuju zanimljiva osnovna stanja kao što su supravodljivost i različiti valovi gustoće naboja (CDW). Slojevi su vezani Van der Waals-ovim silama te je između tih slojeva moguće interkalirati razne atome i molekule. Istraživanja na ovom projektu tiču se različitih interkalacija prijelaznih metala u TMD-e. Uslijed prijenosa dijela naboja sa interkalanata na slojeve domaćina interkalirani ioni nose magnetski moment te se sustav može magnetski urediti. Različiti prijelazni metali pokazuju različita feromagnetska i antiferomagnetska uređenja za različite stupnjeve interkalacije. Zanimljiv je slučaj interkalacije 1/3 magnetskih iona po jediničnoj ćeliji roditeljskog spoja, pošto se tada magnetski ioni urede na trokutastoj rešetci te se u slučaju anitferomagnetskih međudjelovanja među njima javlja frustracija u sustavu. U okviru ovoga projekta planiramo proučavati utjecaj hidrostatskog i uniaksijalnog tlaka na magnetski uređene faze osobito na efekte frustracije te odrediti relativne važnosti različitih međudjelovanja kao što su RKKY, superizmjena i Kondo zasjenjenje te njihovu međuigru. Isto tako planiramo promatrati kako se osnovna stanja roditeljskih spojeva (CDW, supravodljivost) potiskuju interkalacijom/tlakom te kakav je njihov utjecaj na novonastale magnetske faze. Također nas zanima kakav je utjecaj nereda na osnovna stanja kao i mogućnost postojanja topoloških efekata u TMDima. ]]></summary_hr><summary_en><![CDATA[This project proposal is based on transition metal dichalogenides (TMDs). They are a family of layered (quasi two-dimensional) materials which, due to reduced dimensionality, exhibit interesting ground states such as superconductivity and different charge density waves (CDWs). The layers are connected with Van der Waals forces and it is possible to intercalate various atoms and molecules in-between those layers. The research on this project concerns different intercalations of transition metals in TMDs. Due to the transfer of part of the electronic charge from the intercalant to the host layers, intercalated ions carry the magnetic moment and the system can be magnetically ordered. Different transition metals show different ferromagnetic and antiferromagnetic orderings for different intercalation rates. Interesting case is intercalation with 1/3 of magnetic ions per one unit cell of parent compound, since the magnetic ions are then ordered on the hexagonal lattice, and in the case of anitferromagnetic interactions frustration occurs in the system. Within this project, we plan to study the influence of hydrostatic and uniaxial pressure on the magnetically ordered phases, in particular on the effects of frustration and to determine the relative importance of different interactions such as RKKY, superexchange and Kondo screening and their interplay. We also plan to observe how the ground states of parent compounds (CDW, superconductivity) are suppressed by intercalation/pressure, and how they influence newly established magnetic phases. We are also interested in the effect of disorder on the ground state and possibility of topological effects in TMDs.]]></summary_en></project><project>
<id>10133</id><title_hr><![CDATA[Procjena fotosintetske aktivnosti i fotozaštitnog potencijala TROL-FNR razdjelnice]]></title_hr><title_en><![CDATA[Evaluating photosynthetic performance and photoprotective potential of the TROL-FNR bifurcation]]></title_en><user_id>455</user_id><user_firstLast_name>Hrvoje Fulgosi</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2020-02</proposal_call><code>IP-2020-02-8590</code><acronim><![CDATA[FUTURE PLANT]]></acronim><duration>01.01.2021 - 31.05.2025</duration><status>Završio</status><financ_value>161.921,83 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, Interdisciplinarne prirodne znanosti, </scie_field_hr><scie_field_en>Biology, Interdisciplinary natural sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>1001, 26788, 29571, 865086, </team_members_id><team_members_names><![CDATA[Lea Vojta, Alexander Ruban, Lucija Horvat, Ena Dumančić, ]]></team_members_names><keywords_hr><![CDATA[elektronski transport, redoks regulacija fotosinteze, ROS, brzi A-Ci odgovor RACiR, NPQ]]></keywords_hr><keywords_en><![CDATA[electron transport chain, redox regulation of photosynthesis, ROS, rapid A-Ci response RACiR, NPQ]]></keywords_en><summary_hr><![CDATA[Fotosinteza je nedvojbeno najvažniji autotrofni proces na Zemlji. Ona ne samo da osigurava primarnu proizvodnju hrane, već je zaslužna za glavnu izmjenu plinova u atmosferi. Biljke fotosintezom troše ugljični dioksid, a ispuštaju kisik neophodan za život velikog broja vrsta. Za to im je potrebna svjetlost i voda. S obzirom da nisu pokretne, biljke su razvile brojne mehanizme zaštite od prekomjernog osvjetljenja, kao i od drugih stresora. Regulacija protoka energije u fotosintetskom lancu predmet je brojnih istraživanja, a zbog ubrzanih klimatskih promjena interes za ovakva istraživanja je u porastu. Završni prijenos fotosintetskih elektrona na molekulu NADP+ vrši enzim feredoksin NADP+ oksidoreduktaza (FNR). U biljnim kloroplastima FNR se veže na tilakoidne membrane putem proteina TROL (Thylakoid RhOdanase-Like) kojeg smo prethodno otkrili i karakterizirali. Interakcija TROL-FNR je dinamička i igra važnu ulogu u razdiobi fotosintetskih elektrona između procesa koji čuvaju i pretvaraju energiju i onih koji je, kada je u suvišku, rasipaju. FNR vezan na TROL efikasno katalizira linearni prijenos energije i sintezu NADPH, a kada je slobodan FNR sudjeluje u vrlo brzom procesu iskorištavanja elektrona koji sprečava stvaranje reaktivnih kisikovih jedinki (ROS). U ovom ćemo projektu istražiti fotosintetski potencijal TROL-FNR razdjelnice korištenjem najsuvremenije RACiR tehnike mjerenja izmjene plinova. Istražit ćemo i ulogu razdjelnice u zaštitnim procesima nefotokemijskog gašenja fluorescencije klorofila a (NPQ), propagaciji i detoksifikaciji ROS te sintezi fotozaštitnih molekula.]]></summary_hr><summary_en><![CDATA[Photosynthesis is arguably the most important autotrophic process on Earth. It provides primary food production and is responsible for the major atmospheric gas exchange. Plants driving photosynthesis consume CO2 and release oxygen that is pivotal for the life of many species. For this, plants require light and water. Being sessile organisms, plants have evolved numerous protective mechanisms against high-light and other stressors. Regulation of the photosynthetic energy flow is in the focus of modern plant biology research and is gaining importance due to rapid climate changes. Final photosynthetic electron transfer to the NADP+ is performed by the enzyme ferredoxin NADP+ oxidoreductase (FNR). In plant chloroplasts FNR binds to thylakoid membranes via protein TROL (Thylakoid RhOdanase-Like), which was previously discovered and characterized by our group. TROL-FNR interaction is dynamic and plays important role in photosynthetic electron partitioning between energy-conserving and -dissipating processes. TROL-bound FNR effectively catalyzes linear electron transfer and NADPH synthesis, while soluble FNR participates in the rapid electron dissipation, which effectively prevents ROS propagation. In this project, we shell research photosynthetic potential of the TROL-FNR bifurcation by using state-of-the-art RACiR gas exchange measurements. Further, we shell investigate the role of this bifurcation in the protective processes of the non-photochemical quenching of chlorophyll a fluorescence (NPQ), ROS propagation, and synthesis of photoprotective molecules.]]></summary_en></project><project>
<id>10135</id><title_hr><![CDATA[Od aromatskih spojeva s dušikom do novih funkcionalnih organskih materijala]]></title_hr><title_en><![CDATA[From nitrogen-containing aromatic compounds to new functional organic-based materials]]></title_en><user_id>4656</user_id><user_firstLast_name>Ivana Biljan</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2020-02</proposal_call><code>IP-2020-02-4467</code><acronim><![CDATA[FunMaterials]]></acronim><duration>01.01.2021 - 31.01.2025</duration><status>Završio</status><financ_value>125.754,86 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>492, 4669, 12766, 485, 5069, 17739, 29619, 26587, 4668, 865148, 869839, </team_members_id><team_members_names><![CDATA[Vesna Petrović Peroković, Ivan Kodrin, Nikola Cindro, Željka Car, Igor Rončević, Mladen Borovina, Barbara Panić, Petar Šutalo, Hrvoj Vančik, Laura Nuić, Matija Popović, ]]></team_members_names><keywords_hr><![CDATA[aromatske građevne jedinke s dušikom, funkcionalni materijali, modularni dizajn, porozni organski materijali, slojevi na površinama]]></keywords_hr><keywords_en><![CDATA[aromatic building blocks with nitrogen, functional materials, modular design, porous organic materials, surface adlayers]]></keywords_en><summary_hr><![CDATA[Modularni dizajn odozdo prema gore, odnosno pristup povezivanja molekularnih građevnih jedinki unaprijed određene geometrije i funkcionalnosti na predvidljiv način, važan je put prema funkcionalnim organskim arhitekturama. U ovom projektu, osnovna ideja je upotrijebiti strukturno slične molekularne građevne jedinke, aromatske spojeve s dušikom, za dizajn samoudruženih višeslojeva i 2D polimera na čvrstim površinama s mogućom primjenom u molekularnoj elektronici, te za sintezu poroznih organskih materijala koji bi se mogli koristiti za adsorpciju i pohranjivanje plinova.Aromatski C-nitrozo spojevi izloženi na međupovršini metal-otopina koristit će se kao predlošci za hijerarhijsku izgradnju azodioksidnih višeslojeva interakcijama s aromatskim dinitrozo derivatima. Mehanizam nastajanja i kinetika rasta nitrozo/azodioksidnih slojeva na površinama istražit će se elipsometrijom, AFM i STM mikroskopijom te računalnim metodama. Nadalje, provest će se in situ EC-STM istraživanja od kojih se očekuje pružanje informacija o strukturi i dinamici na razini pojedinačnih molekula. Također će se istražiti polimerizacija aromatskih polinitrozo derivata na površinama i moguće nastajanje površinom ograničenih 2D azodioksidnih polimera. Kristalni (COF-ovi) ili amorfni (COP-ovi) porozni organski materijali mogu nastati povezivanjem organskih građevnih jedinki preko kovalentnih veza. Aromatske građevne jedinke s nitrozo, nitro i/ili amino skupinama bit će korištene za modularni dizajn azo, azoksi i azodioksidnih COF-ova i/ili COP-ova. Strukturna i funkcionalna svojstva poroznih materijala bit će karakterizirana spektroskopijom, termičkom analizom, rentgenskom difrakcijom, mjerenjima specifične površine i molekularnim modeliranjem. Cilj je ispitati utjecaj različitih dušik-dušik veza na strukturna (kristalne naspram amorfnih krutina) i funkcionalna svojstva konačnih materijala te identificirati obećavajuće nove porozne sustave za učinkovito hvatanje CO2, glavnog stakleničkog plina.]]></summary_hr><summary_en><![CDATA[A bottom-up modular design, an approach of piecing together molecular building blocks of predetermined geometry and functionality in a predictable manner, is an important route toward the functional organic architectures. Within this project, the basic idea is to employ structurally similar molecular building blocks, nitrogen-containing aromatic compounds, for a design of self-assembled multilayers and 2D polymers on solid surfaces with possible applications in molecular electronics, and for the synthesis of porous organic materials which could be used in gas adsorption and storage. Aromatic C-nitroso groups exposed at the metal-solution interface will be used as templates for hierarchical construction of azodioxy multilayers by interactions with aromatic dinitroso derivatives. Formation mechanism and growth kinetics of nitroso/azodioxy adlayers on surfaces will be explored by ellipsometry, AFM and STM microscopy, and computational methods. In addition, in situ EC-STM studies expected to provide structure and dynamics information at single-molecule level will be performed. Polymerization of aromatic polynitroso compounds on surfaces and possible formation of surface-confined 2D azodioxy polymers will be also investigated. Crystalline (COFs) or amorphous (COPs) porous organic materials can be formed by linking organic building units through covalent bonds. Aromatic building blocks with nitroso, nitro and/or amino groups will be utilized for modular design of azo, azoxy and azodioxy COFs and/or COPs. Structural and functional features of porous materials will be characterized by spectroscopy, thermal analysis, X-ray diffraction, surface area measurements and molecular modelling. The aim is to examine the effect of different nitrogen-nitrogen linkages on structural (crystalline vs. amorphous solids) and functional properties of final materials and to identify the promising new porous organic systems for the effective capture of CO2, the main greenhouse gas.]]></summary_en></project><project>
<id>10138</id><title_hr><![CDATA[Predmoderna hrvatska književnost u europskoj kulturi: kontakti i transferi]]></title_hr><title_en><![CDATA[Premodern Croatian Literature in European Culture: Contacts and Transfers]]></title_en><user_id>5066</user_id><user_firstLast_name>Dolores Grmača</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2020-02</proposal_call><code>IP-2020-02-5611</code><acronim><![CDATA[Econtra]]></acronim><duration>01.02.2021 - 31.05.2025</duration><status>Završio</status><financ_value>66.401,22 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filologija, </scie_field_hr><scie_field_en>Philology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>12609, 7948, 995, 3921, 268, 15992, 2952, 802, 29190, 22693, 29161, 19594, 4310, 5006, 888, 4221, 29073, 29118, 29189, 27007, </team_members_id><team_members_names><![CDATA[Davor Dukić, Divna Mrdeža Antonina, Amir Kapetanović, Tomislav Bogdan, Zrinka Blažević, Maciej Falski, Lahorka Plejić Poje, Ivana Brković, Monica Fin, Saša Potočnjak, Kristina Grgić, Dubravka Dulibić-Paljar, Violeta Moretti, Francesca Maria Gabrielli, Goranka Šutalo, Jasmina Lukec, Josip Vučković, Ana Kadović, Borna Treska, Ivan Lupić, ]]></team_members_names><keywords_hr><![CDATA[predmoderna književnost, kulturni transfer, kulturni kontakti, kulturna baština, hrvatski latinizam, kajkavska književnost, žene autorice]]></keywords_hr><keywords_en><![CDATA[premodern literature, cultural transfer, cultural contacts, cultural heritage, Croatian Latinism, Kajkavian literature, female authors]]></keywords_en><summary_hr><![CDATA[Hrvatska predmoderna književnost predstavlja iznimno plodno tlo za proučavanja kulturnih dodira i književne razmjene zahvaljujući svojem specifičnom položaju na sjecištu različitih kulturnih sfera, koji joj je omogućio prihvaćanje i stvaralačku preobrazbu raznovrsnih kulturnih vrednota. Važnost je predložene teme u činjenici da ne postoje sustavno osmišljena proučavanja starije hrvatske književnosti u europskom interkulturnom kontekstu, koja bi obuhvaćala raspon od samih srednjovjekovnih početaka do 40-ih godina 19. st., te da teorija kulturnog transfera dosad nije primjenjivana u istraživanju tog korpusa tekstova. Projekt se neće baviti samo razmjenom književnih tekstova nego će obuhvatiti i posredovanje drugih kulturnih fenomena između kulturnih regija predmoderne hrvatske književnosti i kultura u kontaktu, i to smještajući je istodobno unutar nacionalnoga i nadnacionalnoga konteksta. Temeljni znanstveni doprinos uključuje rekonstrukciju književnih kontakata i razmjene književnih tekstova; tipološke usporedbe razdoblja, književnih pravaca, stilova i žanrova hrvatske književnosti s talijanskom književnosti te s ostalim europskim književnostima, a poglavito srednjoeuropskim i slavenskim; kao i proučavanje specifičnosti nacionalne književnosti s ciljem nadopune znanstvenih spoznaja i stvaranja novih znanja o nedovoljno istraživanim tematskim poljima. Očekivani rezultati uključuju vrednovanje i objavljivanje dosad nekorištene rukopisne građe iz arhiva, publiciranje znanstvenih članaka, pripremu kritičkih izdanja, monografiju, edukativne radionice, organizaciju 5 znanstvenih skupova te izlaganja rezultata na domaćim i inozemnim konferencijama. Pritom će biti obuhvaćen cjelokupni proces transfera teksta od rukopisnih izvorišta i prijevoda do teorijskih interpretacija njegove recepcije, odražavajući time brigu za integralnu kulturnu baštinu.]]></summary_hr><summary_en><![CDATA[Croatian premodern culture provides a particularly fertile ground for the study of cultural contacts and cultural exchange due to its specific position at the crossroads of different cultural spheres, allowing for it to absorb and creatively transform diverse cultural values. The importance of the proposed research topic lies in the fact that so far there has been no systematically designed research of older Croatian literature in the European intercultural context that would encompass its entire scope, from the medieval beginnings to the 1840s, nor has the cultural transfer theory yet been applied in research of this textual corpus. The project will investigate not only the exchange of literary texts but also the mediation of other cultural phenomena among the regions of premodern Croatian literature and cultures in contact, positioning it simultaneously within the national and supranational contexts. The project’s fundamental contribution to the area of research will entail the reconstruction of literary contacts and exchange of literary texts; typological comparisons of periods, literary movements, styles and genres of Croatian and Italian as well as other European literatures, central European and Slavic in particular; the study of specificities of national literature, with the aim of complementing the existing body of knowledge and generating new insights into the insufficiently investigated thematic areas. The expected project results include evaluation and publication of unused manuscript materials from archives, publication of scientific papers, preparation of critical editions, a monograph and educational workshops, organisation of 5 scientific conferences and presentation of research results at domestic and international conferences. The entire process of textual transfer will thus be encompassed, from manuscript sources and translations to theoretical interpretations of textual reception, reflecting regard for integral cultural heritage.]]></summary_en></project><project>
<id>10140</id><title_hr><![CDATA[Povećanje učinkovitosti, smanjenje štetnih emisija i hibridizacija brodskog energetskog sustava]]></title_hr><title_en><![CDATA[Efficiency Improvement, Emission Reductions and Hybridization of the Marine Power Systems]]></title_en><user_id>3698</user_id><user_firstLast_name>Gojmir Radica</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2020-02</proposal_call><code>IP-2020-02-6249</code><acronim><![CDATA[MOPTIHYB]]></acronim><duration>01.02.2021 - 31.01.2025</duration><status>Završio</status><financ_value>175.592,28 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, Tehnologija prometa i transport, </scie_field_hr><scie_field_en>Mechnical engineering, Transport technology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Fakultet elektrotehnike, strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Electrical Engineering, Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>18920, 25813, 29708, 29704, 5931, 1118, 24103, 855326, 3668, 3868, 865046, 5599, </team_members_id><team_members_names><![CDATA[Željko Penga, Maro Jelić, Karlo Bratić, Branko Lalić, Nikola Račić, Frano Barbir, Vladimir Pelić, Jakov Šimunović, Ivan Tolj, Tomislav Mrakovčić, Tino Vidović, Ozren Bukovac, ]]></team_members_names><keywords_hr><![CDATA[Energetska učinkovitost, štetne emisije, hibridizacija, brodski pogoni, energetski sustavi]]></keywords_hr><keywords_en><![CDATA[Efficiency improvement, Emission reduction, Hybridization, Marine engines, Energy systems]]></keywords_en><summary_hr><![CDATA[Svrha istraživanja je istražiti mogućnosti poboljšanja energetske učinkovitosti i smanjenja emisija štetnih plinova brodskih energetskih sustava, primjenom optimizacije u stvarnom vremenu i inovativnim tehnologijama s fokusom na primjenu vodika i gorivnih članaka (Fuel Cell, FC). Dizelski motori su danas i bit će ubuduće glavni pogonski stroj korišten u pomorskom transportu. Glavni problemi s kojim se proizvođači brodskih dizelskih motora danas susreću su energetska učinkovitost i zaštita okoliša. Kao potencijalno rješenje za smanjenje globalne (CO2) i lokalne (NOx, čađa) razine emisija štetnih ispušnih plinova, predložena su alternativna goriva i hibridizacija sustava. Jedan od glavnih ciljeva istraživanja je istražiti moguću optimizaciju performansi i emisija motora s unutarnjim izgaranjem, koji rade u stvarnim uvjetima. Fokus će biti na dizelskim motorima, jer su konvencionalni brodski pogonski sustavi uglavnom opremljeni brodskim dizelskim motorima. Veliki dvotaktni brodski dizel motori su problematični za modeliranje zbog neprilagođenosti primjene postojećih modela na velike sporokretne dvotaktne dizelske motore, jer postoji veliki broj parametara koji utječe na proces izgaranja, poput oblika otvora i ispušnih ventila, radni protok, te komore za izgaranje, pa se stoga vrlo malo istraživača bavi ovim istraživanjem. Drugi predmet ovog istraživanja su alternativna goriva i inovativni brodski energetski sustavi s ciljem poboljšanja učinkovitosti i smanjenja emisija štetnih plinova brodskih energetskih. Tehnologija koja ima veliki potencijal u pridonošenju smanjenja utjecaja prometnog sektora na okoliš je FC tehnologija, posebno FC s protonskom membranom (Proton Exchange Membrane ili Polymer Electrolyte Membrane, PEM). Analiza životnog vijeka FC pogonskih sustava, kao i optimalna strategija FC integracije u hibridnom sustavu, bit će jedan od fokusa našeg istraživanja.]]></summary_hr><summary_en><![CDATA[The purpose of the research is to investigate the possibilities of improving the energy efficiency and reducing emissions of marine power systems by the implementation of real-time optimization and innovative technologies with the focus on hydrogen and fuel cell application. Diesel engines are today and will be in the future the main power supply in sea transport. Energy conservation and environmental protection are the main problems that engine manufacturers are facing. Researchers have been making a lot of effort over the last decades to analyse energy conversion in internal combustion engines, especially in large two-stroke engines. Alternative fuels and hybridization have been suggested as a potential solution to reduce both global (CO2) and local (NOx, soot) exhaust gas emissions from internal combustion engines. The main objective of the research is to investigate the possible optimization of performance and emissions of an IC engine running under real conditions. The focus will be on Diesel engines, as the conventional marine propulsion systems are mainly equipped with marine Diesel engines. The other important objective is to investigate alternative fuels and innovative marine energy systems to improve efficiency and reduce emissions of energy power pack in a marine application. A technology that has great potential in reducing the environmental impact of the transport sector is hydrogen-fueled fuel cell technology especially polymer electrolyte membrane (PEM) fuel cell. Life cycle analysis of fuel cell propulsion systems, as well as the optimum integration strategy of the fuel cell in a hybrid system, will be in focus of our research.]]></summary_en></project><project>
<id>10141</id><title_hr><![CDATA[Afektivni kognitivni trening: Neuralni, kognitivni i bihevioralni učinci]]></title_hr><title_en><![CDATA[Affective Cognitive Training: Neural, cognitive and behavioral effects]]></title_en><user_id>19040</user_id><user_firstLast_name>Andrea Vranić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2020-02</proposal_call><code>IP-2020-02-6883</code><acronim><![CDATA[ACT]]></acronim><duration>01.01.2021 - 28.02.2025</duration><status>Završio</status><financ_value>52.702,24 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Psihologija, </scie_field_hr><scie_field_en>Psychology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>11134, 24914, 20494, 23586, 865096, </team_members_id><team_members_names><![CDATA[Ivana Hromatko, Erika Borella, Blaž Rebernjak, Marina Maritnčević, Luka Juras, ]]></team_members_names><keywords_hr><![CDATA[kogitivni trening, izvršne funkcije, radno pamćenje, afektivna obrada, EEG, model latentnih promjena, kognitivno starenje ]]></keywords_hr><keywords_en><![CDATA[cognitive training, executive functions, working memory, affective processing, EEG; latent change model, cognitive aging]]></keywords_en><summary_hr><![CDATA[Starenje populacije stavlja fokus na intervencije osnaživanja kognicije. Prihvaćenost kognitivnih treninga narušavaju nejednoznačni nalazi njihove učinkovitosti, nejasna teorijska podloga te heterogenost parametara treninga i mjera učinkovitosti. Ključno za učinkovitost je pitanje dalekog transfera, tj. porasta u mjerama netreniranih sposobnosti i svakodnevnog funkcioniranja. Polazeći od sukladne neuralne osnove izvršnih aspekata radnog pamćenja (RP) i afektivne obrade informacija osmišljen je trening temeljen na modelu izvršnih aspekata RP (Miyake i sur., 1999), uz korištenje afektivnih podražaja. Glavni cilj projekta je provjera učinkovitosti ovog treninga, čija je svrha osnaživanje kognicije i svakodnevnog funkcioniranja starijih. Predložena istraživanja odgovaraju na pet ključnih teorijskih pitanja kognitivne plastičnosti (Willis i Schaie, 2009): razina, mehanizmi, trajanje, transfer i individualni kontekst. Projekt ima tri faze: 1) preliminarna istraživanja i priprema protokola treninga, 2) razvoj mjere svakodnevnog funkcioniranja, 3) provjera neuralnih (EEG), kognitivnih i bihevioralnih učinaka treninga na uzorku koji osigurava uvjete za analize promjena na latentnoj razini. Očekuje se evidentiranje plastičnosti na neuralnoj, kognitivnoj i bihevioralnoj razini te postuliranje njihova međuodnosa. Analiza multigrupnih latentnih promjena omogućuje zaključivanje o promjenama u strukturi kognitivnih funkcija nakon treninga i njihovom transferu na svakodnevno funkcioniranje, što u tradicionalnim istraživanjima treninga zbog malog uzorka i heterogenih mjera učinaka nije osigurano. Istraživanje ima teorijski i praktičan značaj. Ono osigurava spoznaje o međuodnosu razina i mehanizma plastičnosti te njihovog dosega, ključne za napredak područja, a ujedno omogućava sofisticiranu provjeru modela izvršnih funkcija RP. U vrijeme kada osnaživanje kognitivnih funkcija postaje društveni imperativ, projekt će osigurati ekonomičnu i lako dostupnu intervenciju.]]></summary_hr><summary_en><![CDATA[Aging of the population puts a strong emphasis on cognitive training interventions. Studies on training efficacy show ambiguous results due to the heterogeneity in design, method, training protocols, outcome measures and a relative lack of models explaining the gains. A key to training efficacy is far-transfer, i.e. the post-training gain in untrained abilities and everyday functioning. Based on the neural overlap in affective processing and executive working memory (WM), we propose an affective cognitive training grounded in the model of executive function of WM (Miyake et al., 1999). The main goal of the project is the analysis of training, aimed at enhancing cognition and the daily functioning in elderly. Overall, the proposed research conforms to the five key theoretical questions of cognitive plasticity (Willis and Schaie, 2009): level, mechanisms, duration, transfer and individual context. The project has three phases: 1) preliminary preparation of training protocol, 2)  development and validation of measure of everyday functioning, 3) neural (EEG), cognitive and behavioral effects of cognitive training - latent gain analysis. We expect evidence of plasticity at neural, cognitive and behavioral level and the postulation of the interrelation of these effects. The multigroup latent change analysis will enable inferences on the training-related change in the structure of cognitive abilities and their transfer, which is not enabled in typical small sampled studies with heterogeneous outcomes. The project has important theoretical and practical significance. While providing a sophisticated analysis of the model of executive functions of WM, it will provide new insights into the interdependence of different levels and mechanisms of plasticity and their impact on the aspects of everyday functioning in middle-aged adults. At the time when cognitive enhancement becomes a social imperative, the project might ensure a cost-effective and easily accessible intervention.]]></summary_en></project><project>
<id>10142</id><title_hr><![CDATA[Potraga za kvantnim prostorvremenom u spektru KNM za crne rupe i bljeskovima gama zraka]]></title_hr><title_en><![CDATA[Search for Quantum spacetime in Black Hole QNM spectrum and Gamma Ray Bursts]]></title_en><user_id>1153</user_id><user_firstLast_name>Anđelo Samsarov</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2020-02</proposal_call><code>IP-2020-02-9614</code><acronim><![CDATA[QBHQNMGRB]]></acronim><duration>01.03.2021 - 09.07.2025</duration><status>Završio</status><financ_value>124.626,72 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>29107, 26873, 2750, 3371, 26218, 880, 866805, 866806, 867395, 865273, </team_members_id><team_members_names><![CDATA[Nikola Konjik, Kumar Sankar Gupta, Tajron Jurić, Ivica Smolić, Marija Dimitrijevic Ciric, Salvatore Mignemi, Filip Pozar Požar, Ana Bokulić, Naveena Kumara Athithamoole, Nikola Herceg, ]]></team_members_names><keywords_hr><![CDATA[kvazinormalni modovi crnih rupa,nekomutativna geometrija i gravitacija,bljeskovi gama zraka,modificirane disperzijske relacije,zakrivljeni impulsni pr]]></keywords_hr><keywords_en><![CDATA[black hole quasinormal modes, noncommutative geometry and gravity,gamma ray bursts, modified dispersion relations, curved momentum space]]></keywords_en><summary_hr><![CDATA[Unutar  teorije relativnosti crne rupe se pojavljuju kao rezultat  gravitacijskog urušavanja masivnih astrofizičkih objekata. Među ostalim zanimljivim svojstvima crnih rupa je njihovo svojstvo da egzistiraju u stanju stalnog pobuđenja. Doista, realistične crne rupe nikada ne mogu u potpunosti biti opisane svojim intrinsičnim parametrima, s obzirom da se kontinuirano nalaze u perturbiranom stanju. Pobuđenje crne rupe nasljeđuje faza  u njenoj evoluciji   poznata kao &#39;&#39;trnuća zvonjava&#39;&#39; tijekom koje dominiraju kvazinormalni modovi (KNM). Ti modovi moguće pružaju  ključni potpis gravitacijskih valova. Za vrijeme faze &#39;&#39;trnuće zvonjave&#39;&#39; crna rupa  se postupno vraća u nepobuđeno stanje, pri čemu odašilje  gravitacijske valove i Hawkingovo zračenje.Prisustvo deformirane strukture prostorvremena može signal izobličiti. U svrhu opisa takvih učinaka, u ovom projektu namjeravamo koristiti metode nekomutativne (NK) geometrije kako bismo konstruirali prikladne fizikalne modele koji su u stanju uhvatiti se u koštac s novonastalim okolnostima.Cilj ovog projekta je istražiti skalarne, Diracove, vektorske i gravitacijske KNM koje proizlaze iz perturbacija realističnih 4-dimenzionalnih crnih rupa u prisustvu kvantiziranog prostorvremena. Drugim riječima, planiramo istražiti otiske prostornovremenske nekomutativnosti, u obliku u kojem se pojavljuju unutar spektara gravitacijskog i Hawkingovog zračenja od kojih oba imaju porijeklo u perturbacijama realističnih 4-dimenzionalnih crnih rupa. Isti okvir NK geometrije namjeravamo primijeniti u istraživanju svojstava  nelinearnih fizikalnih modela koji prirodno slijede iz okvira nekomutativne geometrije  te učinak rezultirajuće deformacije simetrija i disperzivnih relacija  na propagaciju visokoenergetskih gama zraka.]]></summary_hr><summary_en><![CDATA[Black holes (BH)  are predicted by the theory of general relativity as the result of a gravitational collapse of massive astrophysical objects.  Among other interesting properties of black holes is a property that they exist in a state of constant arousal.   Indeed, realistic black holes can never be fully described by their basic parameters, as they are  always in a state of  perturbation.Black hole perturbation is followed by a ringdown phase which is dominated by quasinormal modes (QNM). These modes may provide key signature of the gravitational waves. During the ringdown phase, black holes  gradually relax  from the initial perturbation by emitting gravitational waves and  Hawking radiation. Notably, the presence of a deformed spacetime  structure may distort this signal. In order to account for such effects, in this project we plan to  utilise the methods of noncommutative geometry (NC) in order to  construct and devise appropriate physical models which would be able to deal with  new circumstances.The aim of this project is to invetigate  the scalar, Dirac, vector and gravitational QNMs resulting from perturbations of realistic 4-dimensional black holes in a presence of  quantized spacetime. In other words, we plan to undertake a search  for  footprints of spacetime noncommutativity, as encoded in the spectra of gravitational and Hawking radiation that both have a source in perturbations of realistic 4-dimensional black holes. Moreover, the same setting of NC geometry we plan to apply in studying the impact of deformation of both the symmetry and the dispersion relations on a propagation of high energy gamma rays  resulting from distant gamma ray bursts.]]></summary_en></project><project>
<id>10147</id><title_hr><![CDATA[Održiva plovidba smanjenom brzinom za nisko-ugljično brodarstvo]]></title_hr><title_en><![CDATA[Sustainable slow steaming for low carbon shipping]]></title_en><user_id>6793</user_id><user_firstLast_name>Nastia Degiuli</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2020-02</proposal_call><code>IP-2020-02-8568</code><acronim><![CDATA[STARSHIP]]></acronim><duration>01.03.2021 - 30.06.2025</duration><status>Završio</status><financ_value>104.817,84 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Brodogradnja, Strojarstvo, Tehnologija prometa i transport, </scie_field_hr><scie_field_en>Naval architecture, Mechnical engineering, Transport technology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>17868, 4580, 24103, 7753, 13223, 864827, 864826, 865012, 5599, 865245, 866576, </team_members_id><team_members_names><![CDATA[Ivana Martić, Roko Dejhalla, Vladimir Pelić, Roberto Žigulić, Sanjin Braut, Marta Pedišić Buča, Tomislav Prosinečki, Alen Marijančević, Ozren Bukovac, Carlo Giorgio Grlj, Atilla Incecik Incecik, ]]></team_members_names><keywords_hr><![CDATA[brod, plovidba smanjenom brzinom, CFD, eksperimenti u bazenu, potrošnja goriva, CO2 emisija, radne značajke glavnog motora, vibracije, zamor]]></keywords_hr><keywords_en><![CDATA[ship, slow steaming, CFD, towing tank experiments, fuel consumption, CO2 emission, main engine performance, vibrations, fatigue]]></keywords_en><summary_hr><![CDATA[Plovidba smanjenom brzinom popularna je mjera koju primjenjuju trgovački brodovi, kao način smanjenja potrošnje goriva, a samim time i operativnih troškova. Smanjenje brzine broda jedna je od mjera za ispunjavanje zahtjeva Međunarodne pomorske organizacije (IMO) za emisijom stakleničkih plinova (GHG). Maersk Lines je prvotno uveo mjeru plovidbe smanjenom brzinom za kontejnerske brodove, a kasnije se ta mjera primjenjuje i na druge vrste brodova, uključujući tankere i brodove za rasuti teret. Tankeri i brodovi za rasuti teret plove gotovo polovinu svog vremena u stanju balasta. To rezultira značajnom promjenom podvodnoga oblika trupa broda i pripadajućih hidrodinamičkih značajki što se rijetko uzima u obzir. Uvođenjem plovidbe smanjenom brzinom, brodovi plove u uvjetima koji se bitno razlikuju od onih za koje su projektirani i optimirani. Plovidba u uvjetima za koje brod nije projektiran može uzrokovati nekoliko pojava kao što su: promjena stupnja djelovanja propulzije i brodskoga vijka, promjena razina vibracija, gubitak učinkovitosti turbopuhala i gubitak učinkovitosti sustava povrata topline. Stoga je važno analizirati ukupne radne značajke broda u uvjetima za koje brod nije projektiran. Projekt uključuje tri glavna cilja koji se odnose na plovidbu u uvjetima za koje brod nije projektiran, a to su: promjena stupnja djelovanja propulzije i brodskoga vijka, promjena radnih značajki glavnoga motora i promjena razine vibracija osovinskoga voda. Projekt je usmjeren k boljem razumijevanju i pružanju novih uvida u prethodno spomenute probleme uslijed plovidbe u uvjetima za koje brod nije projektiran. Rezultati projekta pružit će brodarima i brodovlasnicima nova saznanja vezana uz plovidbu smanjenom brzinom ili pri plovidbi za različita stanja krcanja. Stoga će se na temelju dobivenih rezultata projekta dati preporuke vezane uz plovidbu u uvjetima za koje brod nije projektiran.]]></summary_hr><summary_en><![CDATA[Slow steaming is a popular measure for commercial vessels, as a way of reducing fuel consumption, and therefore operating costs. Reducing ship speed is one of the measures to meet International Maritime Organisation (IMO) requirements for Green House Gas (GHG) emissions. Slow steaming approach is introduced for container shipping by Maersk Lines and later has been applied to other types of ships including tankers and dry bulk ships. Tankers and dry bulk ships sail almost half of their time in ballast load condition. This results in significant change in the underwater hull form shape and the associated hydrodynamic characteristics which is rarely given any consideration. With the current trend towards operation according to the slow steaming approach, ships are operating in conditions that are significantly different to those for which they were designed and optimised. Thus, sailing in off-design conditions can cause several occurrences such as: the change in the propulsion and propeller efficiency, the change in the level of vibration, the loss of turbocharger efficiency and the loss of heat recovery systems efficiency. Therefore, it is important to analyse the ship overall performance in off-design conditions. The project deals with three main issues related to the sailing in off-design conditions, namely the change in the propulsion and propeller efficiency, the change in the main engine operation conditions, and the change in the level of vibration of line shaft. The project is intended to improve understanding and provide new insights of the before mentioned problems due to sailing in off-design conditions. The project results will enable ship operators and shipowners to gain new insights related to the application of slow steaming approach or sailing at different loading conditions. Thus, recommendations related to the sailing in off-design conditions will be provided based on the obtained project results.]]></summary_en></project><project>
<id>10155</id><title_hr><![CDATA[Mogućnost iskorištavanja tradicionalnih sorti jabuka za proizvodnju jabuka i soka od jabuka sa smanjenim udjelom patulina]]></title_hr><title_en><![CDATA[The possibility of exploiting traditional apple cultivars for the production of apples and apple juice with the reduced patulin content]]></title_en><user_id>7405</user_id><user_firstLast_name>Ante Lončarić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2020-02</proposal_call><code>UIP-2020-02-8461</code><acronim><![CDATA[TRAPROCk]]></acronim><duration>01.03.2021 - 28.02.2026</duration><status>U tijeku</status><financ_value>256.917,60 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Prehrambena tehnologija, Poljoprivreda, Biotehnologija, </scie_field_hr><scie_field_en>Food technology, Agriculture, Biotechnology, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Fakultet turizma i ruralnog razvoja u Požegi]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Tourism and Rural Development in Pozega]]></institution_en><team_members_id>334, 7424, 26850, 289, 864973, 5709, </team_members_id><team_members_names><![CDATA[Bojan Šarkanj, Ivana Tomac, Marin  Mihaljević Žulj, Goran Fruk, Ana-Marija Gotal, Antun Jozinović, ]]></team_members_names><keywords_hr><![CDATA[tradicionalne sorte jabuka, P. expansum, patulin, polifenoli, antioksidacijska aktivnost]]></keywords_hr><keywords_en><![CDATA[traditional apple varieties, P. expansum, patulin, polyphenols, antioxidant activity]]></keywords_en><summary_hr><![CDATA[Jabuke spadaju u skupinu voća najpodložnijoj kontaminaciji plijesni Penicillium expansum. Osim skraćenog roka trajanja i ekonomskih gubitaka, kontaminacija plodova ovom plijesni uzrokuje i akumulaciju patulina, mikotoksina čija uloga pri izazivanju bolesti još nije potpuno razjašnjena. Trenutno u svijetu ne postoje zadovoljavajuća rješenja za smanjenje koncentracije patulina u jabukama i proizvodima od jabuka. Međutim, u usporedbi s komercijalnim sortama jabuka, tradicionalne sorte posjeduju veće udjele polifenolnih spojeva, važnih čimbenika u obrani biljke od stresnih uvjeta, veću antioksidacijsku aktivnost te genski profil koji ih čini otpornijim na klimatske uvjete, biljne bolesti i ostale oblike abiotskog stresa. Obzirom na očiglednu prednosti u odnosu na komercijalne sorte jabuka i nedostatak temeljnih istraživanja u ovom području, a s naglaskom na očuvanje bioraznolikosti i ekološku proizvodnju, projektni prijedlog podrazumijeva primijenjena istraživanja tradicionalnih sorti jabuka s ciljem određivanja mogućnosti iskorištavanja tradicionalnih sorti jabuka za proizvodnju jabuka i soka od jabuka sa smanjenim udjelom patulina. Istraživanja obuhvaćaju određivanje utjecaja klimatskih uvjeta tijekom rasta ploda, skladištenja jabuka, fizikalno-kemijskog sastava jabuka na rast plijesni P. expansum i pojavnost patulina u jabukama i soku od jabuka. U svrhu procjene otpornosti odabranih sorti jabuka provest će se inokulacija ploda s plijesni P. expansum te pratiti produkcija patulina. Zbog opsežnosti gore navedenih istraživanja, projektni prijedlog obuhvaća zaposlenje jednog doktoranda kao i obranu doktorske disertacije za vrijeme trajanja projekta. Dobiveni rezultati će poslužiti znanstvenicama koji istražuju strategije smanjenja udjela patulina u jabukama i proizvodima od jabuka, a postavit će i dobru osnovu za odabir prikladne tradicionalne sorte za selektivni rast u cilju ekološke proizvodnje jabuka otpornih na plavu plijesan.]]></summary_hr><summary_en><![CDATA[Apples are among the most popular fruits, however, the commonly found mold, P. expansum invades wounded apples, causing the decay and ensuing the production of patulin, a mycotoxin that negatively affects human health. Currently there are no satisfactory strategies for reducing the patulin concentration in apples and apple products. However, compared to commercial apple cultivars, traditional cultivars have higher amount of polyphenolic compounds, important compounds in the defense of plants against stress conditions, also traditional variates possess higher antioxidant activity and a gene profile that makes them more resistant to climate conditions, plant diseases and other forms of abiotic stress. Given the obvious advantages over the commercial apple cultivars and the lack of fundamental research in this area, with an emphasis on conservation of biodiversity and ecological production, the project proposal implies applied research of traditional apple cultivars with the aim of determining the possibility of exploiting traditional apple cultivars for apple and apple juice production with reduced patulin content. Researches include determining the influence of environment conditions during fruit growth, apple storage and physico-chemical properties on P. expansum and the subsequent production of patulin in apples and apple juice. For assessing the resistance of selected apple cultivars, the inoculation of the fruit with P. expansum will be performed and the production of patulin will be monitored. Due to the extensive research within the project, the project proposal encompasses the employment of a PhD student as well as the defense of the doctoral dissertation during the project. The obtained results will be used by scientists who are researching strategies for reducing patulin content in apple and apple products, and will also set a good basis for selecting suitable traditional selective crops for the purpose of producing blue mold-resistant organic production. ]]></summary_en></project><project>
<id>10158</id><title_hr><![CDATA[Patogeneza citomegalovirusne infekcije u nabubrežnoj žlijezdi]]></title_hr><title_en><![CDATA[Pathogenesis of the cytomegalovirus infection in the adrenal gland]]></title_en><user_id>4652</user_id><user_firstLast_name>Berislav Lisnić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2020-02</proposal_call><code>IP-2020-02-3402</code><acronim><![CDATA[ADRENOPATH-CMV]]></acronim><duration>01.06.2021 - 31.05.2025</duration><status>Završio</status><financ_value>198.194,97 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Medicine]]></institution_en><team_members_id>17754, 19694, 4682, 869773, </team_members_id><team_members_names><![CDATA[Jelena Železnjak, Jelena Tomac, Vanda Juranić Lisnić, Martina Brnjić, ]]></team_members_names><keywords_hr><![CDATA[Nadbubrežna žlijezda, MCMV, citomegalovirus, patogeneza, imunosni odgovor]]></keywords_hr><keywords_en><![CDATA[Adrenal gland, MCMV, cytomegalovirus, pathogenesis, immune response]]></keywords_en><summary_hr><![CDATA[Humani citomegalovirus (HCMV) je široko rasprostranjen virus koji nakon primarne infekcije trajno zaostaje u organizmu domaćina. Kod osoba sa zdravim imunološkim sustavom uzrokuje blage ili nikakve simptome, ali ga se smatra rizičnim čimbenikom za razvoj autoimunih, krvožilnih i malignih bolesti. Štoviše, u osoba s narušenim, kompromitiranim ili nezrelim imunosnim sustavom HCMV može zahvatiti brojne organske sustave i tkiva te uzrokovati višestruka, po život opasna stanja. Većina našeg znanja o infekciji i patogenezi citomegalovirusne bolesti potječe iz istraživanja provedenim na slezeni, jetri, mozgu, žlijezdama slinovnicama i plućima. Međutim, razvoj uspješnijih tretmana ovisi o našem dobrom razumijevanju načina na koji se virus širi po tijelu i koje posljedice može prouzrokovati u svakom tkivu i organu. Među masivno zahvaćene, ali zanemarene organe tijekom infekcije CMV-om ubrajaju se i nadbubrežne žlijezde. Nadbubrežne žlijezde dio su hipotalamičko-hipofizno-adrenalne (HPA) osi, glavnog neuroendokrinog sustava koji, među ostalim funkcijama, regulira naše imunološke i reakcije na stres. Unatoč bitnoj fiziološkoj ulozi nadbubrežnih žlijezdi, kratkoročne i dugoročne funkcionalne posljedice citomegalovirusne infekcije nadbubrežnih žlijezdi, njihova otpornost na reaktivaciju/reinfekciju virusa i imunološki mehanizmi odgovorni za kontrolu virusa u nadbubrežnim žlijezdama velikim su dijelom neistraženi. Glavni cilj predloženog projekta je premostiti gore navedeni jaz i provesti sustavnu i obuhvatnu analizu patogeneze CMV infekcije u nadbubrežnim žlijezdama i identificirati ključne komponente imunološkog sustava odgovorne za obranu nadbubrežnih žlijezdi od citomegalovirusa. Provedene analize mogu rezultirati eksperimentalnim terapijama, tretmanima i/ili dijagnostičkim postupcima koji se mogu prenijeti u kliničku praksu.]]></summary_hr><summary_en><![CDATA[Human cytomegalovirus (HCMV) is a widespread virus that establishes latency and persistence after primary infection in most humans worldwide. In individuals with a healthy immune system, it causes little or no symptoms at all, although it is considered a risk factor for the development of autoimmune, (cardio)vascular and malignant diseases. In contrast, in persons with a suppressed, compromised, or immature immune system, it may cause numerous life-threatening conditions affecting multiple organ systems and tissues. Most of our knowledge about CMV pathogenesis comes from investigations of the following organs in the body: spleen, liver, brain, salivary glands, and lungs, even though the development of more successful treatments relies on our in-depth understanding of how the virus disseminates throughout the body and what consequences it may cause in each tissue and organ. Among massively infected, but apparently disregarded organs during the CMV infection are the adrenal glands (AGs) - part of the hypothalamic-pituitary-adrenal (HPA) axis, a major neuroendocrine system that, among other functions, regulates our immune responses and reactions to stress. Despite the essential physiological role of the AGs, the short and long-term functional consequences of the CMV infection of the AG, the resistance of AG to virus reactivation/reinfection, and immune mechanisms responsible for the control of the virus in AG are mostly unknown. The main goal of the proposed project is to address the above-mentioned gap in our knowledge and provide the first systematic and in-depth analysis of the pathogenesis of the CMV infection in the AG and identify critical immune system components responsible for the defense of the AG against cytomegalovirus. These in-depth analyses have the potential to result in applications, therapies, treatments, and/or diagnostic procedures transferable into clinical practice.]]></summary_en></project><project>
<id>10164</id><title_hr><![CDATA[Galoisove geometrije i koherentne konfiguracije]]></title_hr><title_en><![CDATA[Galois geometry and coherent configurations]]></title_en><user_id>4515</user_id><user_firstLast_name>Andrea Švob</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2020-02</proposal_call><code>UIP-2020-02-5713</code><acronim><![CDATA[GalGeKo]]></acronim><duration>01.01.2021 - 31.12.2025</duration><status>Završio</status><financ_value>170.416,09 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Fakultet za matematiku]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Mathematics]]></institution_en><team_members_id>3468, 23495, 3906, 865315, 868741, </team_members_id><team_members_names><![CDATA[Nina Mostarac, Tin Zrinski, Ana Grbac, Maarten De Boeck, Nour Alnajjarine, ]]></team_members_names><keywords_hr><![CDATA[Galoisove geometrije, koherentne konfiguracije, konačna grupa, Erdos-Ko-Rado skup, diskretna struktura]]></keywords_hr><keywords_en><![CDATA[Galois geometry, coherent configurations, finite group, Erdos-Ko-Rado set, discrete structure]]></keywords_en><summary_hr><![CDATA[Osnovni cilj ovog projekta je dati značajan doprinos raznim granama matematike u području diskretne i kombinatorne matematike, posebno proučavanju Galoisovih geometrija i koherentnih konfiguracija i s njima povezanih konačnih incidencijskih struktura. Osnovna i glavna tema ovog projekta je konstrukcija kombinatoričkih struktura baziranih na Galoisovim geometrijama i koherentnim konfiguracijama. Konstruirat ćemo, analizirati i opisati strukture koje su dobivene iz konačnih grupa, posebno geometrijskih grupa za čiju konstrukciju je potrebno široko znanje iz Galoisovih geometrija. Pokušat ćemo uspostaviti novu perspektivnu istraživačku grupu i time doprinijeti ostvarivanju novih rezultata u spomenutim područjima pritom koristeći nove moderne pristupe istraživanju ovih struktura posebno u području Galoisovih geometrija u čije područje istraživanja spadaju i diskretne strukture. Projekt će se najviše baviti interakcijom između Galoisovih geometrija i kombinatoričkih struktura te njihovom vezom s koherentnim konfiguracijama. ]]></summary_hr><summary_en><![CDATA[The main objective of this project is to make significant contributions to several different areas of mathematics in the field of discrete and combinatorial mathematics, especially to the studies of Galois geometry and coherent configurations and finite incidence structures connected with them.  We will focus on developing methods of construction of combinatorial structures that are relying on Galois geometry and coherent configurations. We will construct, analyse and describe structures obtained from finite groups, especially geometrical groups for which deep study in Galois geometry is crucial. We will try to establish new perspective group and make invaluable results in the mentioned fields using new modern approach to the study of these structures especially in the area of Galois geometry that discrete structures are part of. The project will mostly deal with the interplay between Galois geometry and combinatorial structures and their connection to coherent configurations. ]]></summary_en></project><project>
<id>10165</id><title_hr><![CDATA[Računalno modeliranje udarnih oštećenja kompozitnih konstrukcija]]></title_hr><title_en><![CDATA[Computational modelling of composite structures impact damage]]></title_en><user_id>13620</user_id><user_firstLast_name>Darko Ivančević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2020-02</proposal_call><code>UIP-2020-02-9317</code><acronim><![CDATA[CONCORDE]]></acronim><duration>01.01.2021 - 30.06.2026</duration><status>U tijeku</status><financ_value>212.290,13 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Zrakoplovstvo, raketna i svemirska tehnika, Strojarstvo, </scie_field_hr><scie_field_en>Aerospace, missile and space engineering, Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>29629, </team_members_id><team_members_names><![CDATA[Jakov Ratković, ]]></team_members_names><keywords_hr><![CDATA[Kompozitne konstrukcije, oštećenja, popuštanje, udarno opterećenje, načini popuštanja]]></keywords_hr><keywords_en><![CDATA[Composite structures, damage, failure, impact loading, failure modes]]></keywords_en><summary_hr><![CDATA[Ponašanje kompozitnih konstrukcija pri velikim brzinama deformacije se znatno razlikuje u odnosu na ponašanje u statičkim uvjetima, a taj je utjecaj najviše izražen kod mehaničkih svojstava koja su određena ponašanjem matrice. Iz eksperimentalnih istraživanja popuštanja kompozitnih konstrukcija pri velikim brzinama deformacije može se zaključiti da utjecaj na mehanička svojstava definira i način popuštanja kompozitnih konstrukcija pri udarnom opterećenju. Ovi efekti se u numeričkim proračunima čvrstoće obično zanemaruju jer rezultati eksperimentalnih istraživanja nisu davali jasne  zaključke o posljedicama velike brzine deformacije na mehanička svojstva kompozita i načine popuštanja. U skladu s time, modeli oštećivanja koji su u obzir uzimali utjecaje brzine deformacije nisu omogućavali modeliranje oštećenja pri velikom rasponu brzine udara. Cilj projekta je uspostava nove istraživačke grupe koja će razviti numeričku metodologiju za modeliranje mehanizama popuštanja višeslojnih kompozitnih konstrukcija pri udarnom opterećenju. Pritom će se razmatrati širok raspon brzina udara te će metodologija omogućiti točnije modeliranje oštećenja u inženjerskim primjenama poput udara stranih tijela u konstrukciju aviona, sudara kompozitnih automobilskih konstrukcija, balističkog udara u kompozitne kacige i slično. Metodologija će se temeljiti na najnovijim eksperimentalnim spoznajama o ponašanju kompozitnih materijala pri velikim brzinama deformacije uzimajući u obzir utjecaje na tenzor elastičnosti, čvrstoće i brzinu oslobađanja energije deformacije a razmatrati će se svi relevantni načini popuštanja pri udarnom opterećenju. Hipoteza istraživanja je da će primjena adekvatnih konstitutivnih modela, kriterija popuštanja te mehanizama oštećivanja omogućiti pouzdanije i točnije predviđanje načina popuštanja kompozitnih konstrukcija pri udarnim pojavama. ]]></summary_hr><summary_en><![CDATA[The behaviour of composite structures at high strain rates differs considerably from the behaviour in static conditions. This effect is most pronounced in the mechanical properties which are determined by the matrix mechanical properties. Based on the experimental studies of failure of composite structures at high strain rates, it can be concluded that the effect on the mechanical properties defines the failure mode of the composite structure at impact loading conditions. These effects are often neglected in numerical structural simulations as the results of experimental research did not give a clear conclusion on the high strain rate effect on mechanical properties and failure modes in composites. Accordingly, damage models in which high strain rate effects were considered did not allow for modelling of damage at a wide range of impact velocities.The aim of the project is the establishment of a new research group that will develop a numerical methodology for modelling laminated composite structure failure modes at impact loading conditions. A wide range of impact velocities will be considered, and the methodology will enable more accurate modelling of damage in engineering applications as e.g. foreign object impact in aircraft structures, crashworthiness of composite automotive structures, ballistic impact in composite helmets and similar. The methodology will be based on the latest experimental knowledge of the behaviour of composite materials at high strain rates, considering the influence on the tensor of elasticity, strength strain energy release rate while all relevant failure modes will be considered. The hypothesis of the research is that the application of adequate constitutive models, failure criteria and damage models will enable a more reliable and accurate prediction of the composite structure failure modes at impact loading.]]></summary_en></project><project>
<id>10167</id><title_hr><![CDATA[Manganovi metalosenzori]]></title_hr><title_en><![CDATA[Manganese Metallosensors]]></title_en><user_id>4270</user_id><user_firstLast_name>Branimir Bertoša</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2020-02</proposal_call><code>IP-2020-02-3446</code><acronim><![CDATA[MaMes]]></acronim><duration>01.02.2021 - 30.06.2025</duration><status>Završio</status><financ_value>127.036,30 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, Biologija, Interdisciplinarne prirodne znanosti, </scie_field_hr><scie_field_en>Chemistry, Biology, Interdisciplinary natural sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>12733, 25952, 5754, 690, 23182, 29687, 29706, 1106, 865143, 867217, 869901, </team_members_id><team_members_names><![CDATA[Nikola Bregović, Zoe Jelić Matošević, Iva Juranović Cindrić, Ivana Leščić Ašler, Ante Bubić, Pedro Fernandes, Ignacy Cukrowski, Predrag Novak, Katarina Radman, Martina Manenica, Silvia-Maria Franov, ]]></team_members_names><keywords_hr><![CDATA[metalosenzori, alosterija, molekularni mehanizam, transkripcijski faktor, homeostaza mangana u bakterijama, molekularna dinamika, metaloproteini]]></keywords_hr><keywords_en><![CDATA[metallosensors, allostery, molecular mechanism, transcriptional factor, manganese homeostasis in bacteria, molecular dynamics, metalloproteins]]></keywords_en><summary_hr><![CDATA[Manganovi metalosenzori su transkripcijski faktori odgovorni za regulaciju homeostaze mangana u mnogim bakterijama. Četiri manganova metalosenzora su u fokusu projekta, a izabrani su tako da su po dva metalosenzora međusobno homologni proteini od kojih je jedan iz patogene, a drugi iz bakterije koja je uglavnom bezopasna za čovjeka. Jedan par magnanovih metalosenzora tvore međusobno homologni MntR proteini iz bakterije Mycobacterium tuberculosis, uzročnika tuberkuloze, i Bacillus subtilis, nepatogene bakterije koja je sastavni dio crijevne flore kod ljudi. MntR metalosenzori su esencijalni za navedene bakterije. Drugi par tvore manganovi metalosenzori SloR iz bakterije Streptococcus mutans i ScaR iz bakterije Streptococcus gordonii koji su međusobno homologni i oba su od esencijalne važnosti za bakteriju. Bakterija Streptococcus mutans je glavni uzročnik karijesa. Alosterički mehanizmi manganovih metalosenzora i njihove interakcije s pripadnom DNA sekvencom istražit će se interdisciplinarnim pristupom koji uključuje računalne i eksperimentalne metode istraživanja. Od računalnih metoda koristit će se primarno simulacije molekularne dinamike te kvantno mehaničke metode u svrhu parametrizacije interakcija Mn2+ iona i proteina. Eksperimentalne metode koje će se koristiti za istraživanje u sklopu projekta su: izotermalna titracijska mikrokalorimetrija (ITC), UV/Vis spektrofotometrija, nuklearna magnetska rezonancija (NMR), elektronska paramagnetska rezonancija (EPR), fluorescencijska anizotropija (FA) te genetičke i biokemijske metode potrebne za dobivanje i pročišćavanje odgovarajuće količine proteina. S obzirom da se projekt bazira na temeljnom znanstvenom istraživanju, rezultati projekta imat će prvenstveno fundamentalni značaj. Međutim, s obzirom da su dva od četiri manganova metalosenzora esencijalni za patogene bakterije, rezultati projekta mogli bi predstavljati temelj za buduća farmakološka istraživanja.]]></summary_hr><summary_en><![CDATA[Manganese metallosensors are transcriptional factors that regulate manganese homeostasis in bacteria. The focus of the project is on two pairs of manganese metallosensors, each pair consisting of two homologous proteins, one from a pathogenic bacterium and the other from a bacterium that is mostly harmless for humans. We will study the MntR manganese metallosensors from Mycobacterium tuberculosis, the causative agent of tuberculosis, and Bacillus subtilis, a non-pathogenic bacterium that is part of the normal gut flora of humans. Both MntR proteins are essential for their bacteria and are homologues. Manganese metallosensors SloR from Streptococcus mutans, and ScaR from Streptococcus gordonii, are also homologous proteins and both are essential for bacteria. The bacterium Streptococcus mutans is the main causative agent of caries. Allosteric mechanisms of manganese metallosensors and their interactions with the target DNA sequences will be studied by interdisciplinary approach consisting of computational and experimental methods. Computational methods will mostly rely on molecular dynamics simulations. Quantum mechanics calculations will be used for parametrisation of interactions between manganese ions and proteins. Experimental methods will consist of: isothermal titration calorimetry (ITC), UV-Vis spectrophotometry, fluorescence anisotropy (FA), nuclear magnetic resonance (NMR) and electron paramagnetic resonance (EPR), preceded by molecular biology and biochemistry methods necessary to produce sufficient amounts of proteins. The expected results of the project will primary have impact on fundamental science. However, considering the fact that two out of four metallosensors are essential for pathogenic bacteria, the results of the project might serve as a basis for future pharmacological research. ]]></summary_en></project><project>
<id>10172</id><title_hr><![CDATA[Gubici uslijed vrtložnih struja u otvorenoj jezgri transformatora]]></title_hr><title_en><![CDATA[Eddy current losses in open core of transformer]]></title_en><user_id>319</user_id><user_firstLast_name>Bojan Trkulja</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2020-02</proposal_call><code>IP-2020-02-2369</code><acronim><![CDATA[GOJTRA]]></acronim><duration>15.12.2020 - 14.12.2024</duration><status>Završio</status><financ_value>90.649,68 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>17803, 24102, 328, 2792, 319, 865060, </team_members_id><team_members_names><![CDATA[Ana Drandić, Stjepan Frljić, Martin Dadić, Igor Žiger, Bojan Trkulja, Mario Filipašić, ]]></team_members_names><keywords_hr><![CDATA[Naponski transformatori velike snage, laminirana otvorena jezgra, vrtložne struje, gubici, metoda konačnih elemenata]]></keywords_hr><keywords_en><![CDATA[power voltage transformer, laminated open core, eddy currents, losses, finite element method]]></keywords_en><summary_hr><![CDATA[Naponski transformatori velike snage (kombinacija energetskih i mjernih transformatora) imaju rastući tržišni potencijal kako pri napajanju vlastite potrošnje tako i u elektrifikaciji udaljenih područja. Jedinstveni hrvatski koncept takvih transformatora s otvorenom jezgrom se već dokazao na svjetskom tržištu. Za daljnji uspjeh tog koncepta nužno je stalno unapređivanje postupaka za projektiranje i konstrukciju otvorenih jezgara. Gubici u jezgri su temeljni parametar pri projektiranju jezgre, a posebno su značajni gubici uslijed vrtložnih struja. Proračun tih gubitaka u zatvorenoj jezgri složenoj od niza lamela od magnetskog lima se istražuje i unapređuje već dugi niz godina. Najčešće se inducirane struje i gubici  određuju na temelju izračunate raspodjele magnetskog toka. Zbog vrlo nepovoljnog omjera dimenzija (debljina lima manja od milimetra, širina od nekoliko desetaka milimetara, a visina od nekoliko metara), te izrazito nehomogene raspodjele gustoće magnetskog toka pri krajevima jezgre rezultati tih istraživanja nisu primjenjivi za otvorene jezgre. Uz geometriju modela, ključni podatak za izračun gubitaka jesu karakteristike magnetskog materijala. One su izrazito nelinearne, a njihova dostupnost u zadovoljavajućoj točnosti je jako ograničena.  U okviru ovog istraživanja će  se:•	razviti teorijska podloga za numerički proračun raspodjele gustoće magnetskog toka i vrtložnih struja u otvorenim jezgrama;•	izraditi algoritmi za proračun i ugraditi u  programski paket za proračun vrtložnih struja i gubitaka u otvorenoj jezgri naponskog transformatora velike snage;•	verificirati rezultati proračuna usporedbom s mjerenjima na više modela jezgri u tvrtki  u Končar - Mjerni transformatori;•	razviti uređaj za automatizirano mjerenje nelinearnih karakteristika feromagnetskih materijala u velikoj točnosti.]]></summary_hr><summary_en><![CDATA[Power voltage transformers (combination of instrument and power transformer) are an expanding product niche, both for auxiliary power and rural electrification applications. Unique Croatian concept of such transformers with the open core is already successful in the global market.  Continuous improvement of procedures for design and construction of open cores is necessary for further market success. Losses in the core are a fundamental parameter in the design and eddy current losses are particularly important. Calculation of these losses in closed cores built of magnetic laminations has been researched and developed for many years. Most frequently, induced currents and losses are determined based on calculated distribution of magnetic flux. Results of these researches cannot be applied to open cores because of adverse ratio of dimensions (thickness of lamination is less than one millimeter; width of the core is several centimeters and height is a few meters) and extremely inhomogeneous distribution of the magnetic flux density at open ends of the core. Necessary data for calculation of losses are magnetic characteristics of material. They are extremely nonlinear and   their accession in acceptable precision is very limited. Aims of this research are:•	development of theoretical basis for numerical computation of magnetic flux density distribution and eddy currents in open cores;•	creation of computation algorithms and programming of a package for computation of eddy currents and losses in open core of power voltage transformer•	verification of calculation results by comparison to measurements on models of cores in the firm Končar – Instrument transformers•	development of an automated system for measuring of nonlinear magnetic characteristics of ferromagnetic materials in high precision.]]></summary_en></project><project>
<id>10174</id><title_hr><![CDATA[Nova paradigma utvrđivanja odbacivanja presatka srca: dijagnostika fazno-kontrastnim oslikavanjem X-zrakama proizvedenim sinkrotronom]]></title_hr><title_en><![CDATA[New Paradigm in Graft Rejection Detection in Heart Transplantation Recipients: Diagnostic Utility of Synchrotron X-ray Phase Contrast Imaging]]></title_en><user_id>3349</user_id><user_firstLast_name>Maja Čikeš</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2020-02</proposal_call><code>IP-2020-02-5572</code><acronim><![CDATA[GRAFT-XPCI]]></acronim><duration>03.05.2021 - 02.05.2025</duration><status>Završio</status><financ_value>119.580,07 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Kliničke medicinske znanosti, Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Clinical sciences, Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>7344, 7462, 29771, 29770, 5393, 3522, 7352, 23938, 855293, 3376, 1021, 855301, 855308, 855307, 855304, 855322, 13689, 7185, 865272, </team_members_id><team_members_names><![CDATA[Ivo Planinc, Davor  Miličić, Hector Dejea I Velardo, Anne BONNIN, Sven Lončarić, Nina Jakuš, Marijan Pašalić, Igor Rudez, Patricia Garcia-Canadilla, Ivana Ilić, Boško Skorić, Marta Farrero-Torres, Bart Bijnens, Marta Sitges, Ana Garcia,  María Angeles Castel, Hrvoje Jurin, Hrvoje Gasparovic Gasparovic, Nikola Škreb, ]]></team_members_names><keywords_hr><![CDATA[Zatajivanje srca, transplantacija srca, odbacivanje srca, endomiokardna biopsija, sinkrotron, virtualna histologija]]></keywords_hr><keywords_en><![CDATA[Heart failure, heart transplantation, heart graft rejection, endomyocardial biopsy, synchrotron imaging, virtual histology]]></keywords_en><summary_hr><![CDATA[	Zatajivanje srca je rastući javnozdravstveni problem, visokog mortaliteta i ekonomskog opterećenja, pogotovo u uznapredovalom obliku. Zlatni standard u liječenju uznapredovalog zatajivanja srca je transplantacijsko liječenje. 	Pažljivo praćenje bolesnika nužno je za prepoznavanje komplikacija poput odbacivanja ili vaskulopatije presatka, infekcija, karcinoma. Temeljna dijagnostička metoda praćenja tih bolesnika je patohistološka analiza svjetlosnom mikroskopijom uzorka miokarda dobivenog invazivnom endomiokardnom biopsijom. Dostupne patohistološke metode su vremenski zahtjevne, strukturno oštećuju tkiva, nisu kvantitativne, te mogu propustiti dio informacija obzirom na dvodimenzijsko proučavanje trodimenzijskog uzorka.	Ovaj Istraživački projekt ima cilj interdisciplinarnog povezivanja znanstvenika s područja kliničke medicine, kardiovaskularne patologije, te biomedicinskog inžinjerstva i fizičara u uvođenju nove slikovne metode u dijagnostiku stupnja staničnog odbacivanja presatka srca - fazno-kontrastnog oslikavanja X-zrakama proizvedenim sinkrotronom. Ova slikovna metoda je nedestruktivna, ne zahtjeva pripremu uzorka, omogućava trodimenzijsko oslikavanje cijelog uzorka miokarda. Znanstvenici ovog istraživačkog tima već su sudjelovali u pilot projektima oslikavanja animalnih i humanih tkiva navedenom metodom.	GRAFT-XPCI projektom planiramo dokazati neinferiornost nove metode virtualne histologije sinkrotronom u odnosu na klasičnu svjetlosnu mikroskopiju u analizi staničnog odbacivanja presatka srca, usporediti kliničke ishode bolesnika kojima je stanično odbacivanje procijenjeno klasičnom histologijom naspram virtualne histologije, te istražiti karakteristike ostalih tkivnih elemenata u uzorcima biopsija. Inžinjerski dio tima razvit će računarski alat za (polu-)automatsko analiziranje i kvantifikaciju uzoraka, te u konačnici strukturne i kliničke podatke integrirati metodama strojnog učenja, time nadopunivši razumijevanje kroničnog zatajivanja presatka srca.]]></summary_hr><summary_en><![CDATA[Heart failure is a growing public health concern, with high mortality and increasing economic burden, especially when advanced; heart transplantation is still the gold standard for the treatment of advanced heart failure.Close post-transplant follow-up is essential for timely recognition of complications: graft rejection, allograft vasculopathy, infections, malignancies. The main diagnostic method in monitoring cellular graft rejection is classical histology of a myocardial sample by light microscopy, obtained by invasive endo-myocardial biopsy. Current histological methods are time consuming, structurally damaging to the tissue, mostly not quantitative and relevant diagnostic features may be missed – the analyses are performed on only a few 2D slices of a 3D sample. This research project aims at creating an interdisciplinary, synergistic working environment for scientists from clinical medicine, cardiovascular pathology, biomedical engineering and physics to implement a novel imaging method in diagnostics of cellular graft rejection - synchrotron derived X-ray phase-contrast imaging. It is non-destructive, not requiring tissue staining or slicing, providing 3D imaging datasets of the whole biopsy sample; the team members of GRAFT-XPCI have already collaborated on pilot projects of imaging animal and human samples with the method. The objectives of GRAFT-XPCI are to prove non-inferiority of synchrotron virtual histology in comparison to classical histology, compare clinical outcomes after cellular graft rejection staged by classical histology and synchrotron virtual histology, and analyse characteristics of other myocardial microstructure components detected in the samples. The engineering team will develop tools for (semi-)automatic analysis and quantification of myocardial tissue characteristics, and use machine learning algorithms to integrate imaging and clinical parameters to gain additional insights into the processes underlying chronic cardiac graft failure.]]></summary_en></project><project>
<id>10175</id><title_hr><![CDATA[Potencijal arbuskularne mikorize da mijenja obranu vinove loze od virusa]]></title_hr><title_en><![CDATA[Arbuscular mycorrhiza potential to modify grapevine defence against viruses]]></title_en><user_id>2826</user_id><user_firstLast_name>Tomislav Radić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2020-02</proposal_call><code>IP-2020-02-8397</code><acronim><![CDATA[Myco Grape]]></acronim><duration>15.01.2021 - 14.01.2025</duration><status>Završio</status><financ_value>129.245,47 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, Biotehnologija, Interdisciplinarne biotehničke znanosti, </scie_field_hr><scie_field_en>Agriculture, Biotechnology, Interdisciplinary biotechnical sciences, </scie_field_en><institution_hr><![CDATA[Institut za jadranske kulture i melioraciju krša]]></institution_hr><institution_en><![CDATA[Institute for Adriatic Crops and Karst Reclamation in Split]]></institution_en><team_members_id>3236, 12462, 23869, 29121, 29198, 865019, 866589, 866592, 26106, </team_members_id><team_members_names><![CDATA[Katarina Hančević, Matevž Likar, Marjana Regvar, Raffaella Balestrini, Giorgio Gambino, Emanuel Gaši, Vicent Arbona, Miguel Gonzalez Guzman, Mate Čarija, ]]></team_members_names><keywords_hr><![CDATA[arbuskularna mikoriza, vinova loza, virusi, interakcije, fiziološki biljni odgovor]]></keywords_hr><keywords_en><![CDATA[arbuscular mycorrhiza, grapevine, viruses, interactions, physiological plant response]]></keywords_en><summary_hr><![CDATA[Za arbuskularne mikorizne gljive (AMF) je dokazano da imaju potencijal smanjiti biotički stres kod biljaka i aktivirati mikorizom-induciranu otpornost. Međutim, postoje značajna nerazjašnjena pitanja o učinkovitosti AMF zaštite protiv biljnih virusa, a na vinovoj lozi takva istraživanja nisu rađena. U ovom projektu ćemo se baviti funkcionalnom interakcijom između vinove loze, AMF i virusa, imajući na umu sljedeće: globalnu važnost vinogradarstva, visok afinitet vinove loze za arbuskularnu mikoriznu simbiozu, potencijal AMF da ublaži biotički stres i nedostatak istraživanja o interakcijama biljaka, AMF i virusa na drvenastim poljoprivrednim kulturama. Kako bismo razjasnili postojeće nejasnoće o funkcionalnoj interakciji između vinove loze, AMF i virusa te procijenili potencijal AMF da mijenja virusnu infekciju vinove loze, postavit ćemo dva staklenička eksperimenta i jedan podeksperiment. Ciljevi projekta su: 1. odrediti kako pred- i postinokulacija s AMF utječe na fiziološke i molekularne odgovore vinove loze na virusnu infekciju, 2. kvantificirati vremensku i prostornu dinamiku virusne infekcije nakon cijepljenja, u ovisnosti o mikoriznom statusu lozne podloge, 3. istražiti može li zajednička mikorizna mreža između bezvirusne i virusom inficirane vinove loze biti signalni put upozorenja na viruse, 4. osnažiti znanstveni kapacitet Instituta za jadranske kulture uvođenjem funkcionalne genomike u njegova istraživanja interakcija između biljaka i mikroorganizama. Okrupnjivanje istraživanja ćemo postići uspostavom suradnje između četiri istraživačke institucije iz Hrvatske, Slovenije i Italije. U svjetlu održive poljoprivrede i nužnosti razvitka novih alata, od interesa je procijeniti korist upotrebe AMF u integriranom upravljanju zaštitom vinove loze od  virusa.]]></summary_hr><summary_en><![CDATA[Arbuscular mycorrhizal fungi (AMF) are proven to have potential for alleviation of biotic stress in plants and activation of mycorrhiza-induced resistance. However, there are significant gaps in the knowledge on bioprotection efficiency of AMF against the plant viruses and no investigations were conducted on the grapevine.  In this project we will address the functional interplay among the grapevine-AMF-viruses, having in mind the following: global importance of viticulture, grapevine high affinity to the arbuscular mycorrhizal symbiosis, AMF potential to alleviate biotic stress and lack of studies on plant-AMF-virus interactions at any woody crop. In order to elucidate the gaps in the knowledge on the functional interactions between grapevine, viruses and AMF and to estimate AMF potential to modify grapevine virus infection, we will set up two greenhouse experiments and one sub-experiment. The project objectives are: 1. to determine how pre- and post-inoculation with AMF affects grapevine physiological and molecular responses to virus infection; 2. to quantify temporal and spatial dynamics of virus infection after the grafting, depending on the rootstock mycorrhizal status; 3. to explore whether common mycorrhizal network between virus free and virus infected grapevine can be a pathway for virus warning signalling; 4. to strengthen scientific capacity of the Institute for Adriatic Crops by introducing functional genomics into its research of plant-microorganisms interactions. We will achieve consolidation of complementary research and equipment through established connections between four research institutions from Croatia, Slovenia and Italy. In view of sustainable agriculture and the necessity of new tools development, the proposed topic is of importance for evaluating the benefit of AMF application in an integrated viral management in viticulture.]]></summary_en></project><project>
<id>10178</id><title_hr><![CDATA[Utjecaj autohtonih ne-Saccharomyces kvasaca na aromu vina ]]></title_hr><title_en><![CDATA[Impact of native non-Saccharomyces yeasts on wine aromas]]></title_en><user_id>1182</user_id><user_firstLast_name>Irena Budić-Leto</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2020-02</proposal_call><code>IP-2020-02-1872</code><acronim><![CDATA[WINE AROMAS]]></acronim><duration>15.01.2021 - 14.01.2025</duration><status>Završio</status><financ_value>122.705,00 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Prehrambena tehnologija, </scie_field_hr><scie_field_en>Food technology, </scie_field_en><institution_hr><![CDATA[Institut za jadranske kulture i melioraciju krša]]></institution_hr><institution_en><![CDATA[Institute for Adriatic Crops and Karst Reclamation in Split]]></institution_en><team_members_id>28969, 1427, 7171, 2795, 865017, </team_members_id><team_members_names><![CDATA[Vesna Milanovic, Jasenka Gajdoš Kljusurić, Urska Vrhovsek, Ana Mucalo, Ana Boban, ]]></team_members_names><keywords_hr><![CDATA[autohtoni ne-Saccharomyces kvasci, enološki potencijal, aroma, vino, metabolomika]]></keywords_hr><keywords_en><![CDATA[native non-Saccharomyces yeasts, oenological potential, aroma, wine, metabolomics]]></keywords_en><summary_hr><![CDATA[Trenutne spoznaje ukazuju na značajne razlike između sposobnosti S. cerevisiae i ne-Saccharomyces u oslobađanju tiola i pojedinih prekursora arome grožđa. Lipidi su među spojevima u grožđu koji imaju važnu ulogu u kvaščevom metabolizmu jer izgrađuju njihove stanične stijenke. Tolerancija kvasca na stres, što uključuje etanol, octenu kiselinu ili acetaldehid snažno je pod utjecajam lipidnog sastava njegove stanične membrane. Upotreba kvasca dobivenih iz ekosustava vinograda može povećati tipičnost i autentičnost vina iz toga područja, dovodeći mikrobiom vinograda u prvi plan, što se često naziva i mikrobni teroir. Glavni ciljevi predložene studije za sortu „Maraština“  iz obalnog područja Hrvatske su: (i) Izolirati i identificirati autohtone ne-Saccharomyces kvasace; (ii) Karakterizirati enološki potencijal autohtonih ne-Saccharomyces kvasaca; (iii) Utvrditi utjecaj specifičnih autohtonih ne-Saccharomyces kvasaca na sortni i fermentacijski sastav arome vina. U suradnji sa stručnim znanstvenicima u području metabolomskih istraživanja u Fondazione Edmund Mach, Research and Innovative Centre u Italiji, (FEM) definirat ćemo cijeli profil arome grožđa i vina, uključujući spojeve u vrlo niskoj koncentraciji, kako bismo poboljšali razumijevanje utjecaja kvasaca na stvaranje relevantnih kemijskih spojeva. Ovaj će nam skup podataka pomoći u analizi i razumijevanju složenih interakcija između kvasaca i kemijskih spojeva grožđa, prije svega onih koji su odgovorni za aromu sorte i onih sintetiziranih tijekom alkoholne fermentacije grožđa uzgojenog u specifičnim, ekološkim uvjetima, tople mediteranske klime. Ovaj projekt daje uvid u potencijalne nove starter ne-Saccharomyces kulture, s nizom sojeva koje će se karakterizirati s obzirom na njihov potencijalni učinak na profil arome vina. Rezultati ovog projekta bit će korisni za vinsku industriju. To će biti čvrsta znanstvena osnova za odabir autohtonih kvasca koji će vinarima pružiti izgradnju kompleksnijeg stila vina.]]></summary_hr><summary_en><![CDATA[Current knowledge has shown marked differences between S. cerevisiae and non-Saccharomyces ability to release thiols and other varietal aroma precursors available in grape. Lipids are among compounds in grapes which can play an important role in yeast metabolism because they are involved in the structure of yeast cells. Yeast stress tolerance and its resistance to ethanol, acetic acid or acetaldehyde are strongly influenced by lipid composition of its cell membrane. The use of non-Saccharomyces yeasts derived from a vineyard ecosystem may enhance the typicity and authenticity of the wines, bringing the vineyard microbiome to the fore of the terroir concept, often referred to as microbial terroir. The main objectives of the proposed study for ‘Maraština’ grapes are: (i) Isolation and identification of the native non-Saccharomyces yeasts; (ii) Screening of oenological characteristics of the native non-Saccharomyces yeasts; (iii) Determining the influence of specific native non-Saccharomyces yeasts on the varietal and fermentative aroma composition of wine. In cooperation with expert scientists in the field of metabolomics research at Fondazione Edmund Mach, Italy, (FEM) we will define the entire aroma profile, including compounds at very low concentration, to improve understanding of the impact of yeasts on the formation of relevant chemical compounds. This data set will help us to understand the interactions between yeasts and the grape compounds, primarily those responsible for the varietal aroma and those synthesized during the alcoholic fermentation of the variety cultivated in specific ecological conditions of warm Mediterranean climate. This project provides promising insights into potential new non-Saccharomyces starter cultures, with a number of species characterized in terms of potential effect on aroma profile following sequential fermentation with commercial S. cerevisiae strain. The results of this project will be useful for wine industry. ]]></summary_en></project><project>
<id>10182</id><title_hr><![CDATA[Genetske, gospodarske i društvene interakcije programa očuvanja lokalnih pasmina]]></title_hr><title_en><![CDATA[Genetic, economic and social interactions of local breed conservation programs]]></title_en><user_id>20459</user_id><user_firstLast_name>Ante Ivanković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2020-02</proposal_call><code>IP-2020-02-4860</code><acronim><![CDATA[GGD LocBreed]]></acronim><duration>01.01.2021 - 31.05.2025</duration><status>Završio</status><financ_value>125.442,96 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, Biotehnologija, Prehrambena tehnologija, </scie_field_hr><scie_field_en>Agriculture, Biotechnology, Food technology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Agronomski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Agriculture]]></institution_en><team_members_id>3970, 23742, 22742, 23624, 23719, 29702, 822, 3008, 29722, 29716, 865386, </team_members_id><team_members_names><![CDATA[Marija Cerjak, Jelena Ramljak, Nikolina Kelava Ugarković, Miljenko Konjačić, Mateja  Pećina, Gordan Šubara, Jasna Aladrović, Lana Pađen, EDMONDO ŠURAN, Giovanni Bittante Bittante, Zdenko Ivkić, ]]></team_members_names><keywords_hr><![CDATA[Lokalne pasmine, programi očuvanja, genetska vrijednost, kompetitivnost, društveni stavovi]]></keywords_hr><keywords_en><![CDATA[Local breeds, conservation programs, genetic value, competitiveness, social attitudes]]></keywords_en><summary_hr><![CDATA[Najveći broj lokalnih pasmina domaćih životinja je tijekom dvadesetog stoljeća bio zanemaren, prvenstveno radi njihove niže proizvodne konkurentnosti. Danas društvo cijeni lokalne pasmine kao vrijedno genetsko i kulturno naslijeđe, važno za sigurnost proizvodnje hrane, održavanje prepoznatljivosti ruralnih prostora i bioraznolikosti, ne zanemarujući njihovu aktualnu ili moguću gospodarsku važnost. Neke lokalne pasmine zadnjih desetljeća dovedene na rub opstanka te društvo nastoji javnim sredstvima potaknuti razvoj održivih sustava proizvodnje ugroženih lokalnih pasmina. Dosadašnja iskustva u razvoju održivih sustava zaštite lokalnih pasmina naglašavaju potrebu uravnoteženog i višestranog fokusiranja na sve sudionike konzervacijskih programa. Predloženo znanstveno istraživanje ima za cilj na primjeru pet hrvatskih lokalnih pasmina (istarsko govedo, buša, primorsko-dinarski i istarski magarac, hrvatski posavac) smještenih na različitim geografskim područjima utvrditi genetske, gospodarske i društvene indikatore lokalnih pasmina te utvrditi  interakcije utvrđenih indikatora. Za procjenu genetskih indikatora koristiti će se analiza rodovničkih zapisa, genetipizacija mikrosatelita, te određenih polimorfnih genskih lokusa. Proizvodni indikatori procijeniti će se prikupljanjem fenotipskih deskriptora, deskriptora karakteristika trupa prikupljenih na liniji klanja te kakvoće mesa. Analizom kemijskog sastava mesa te promjenama u sastavu masnih kiselina i aminokiselina tijekom zrenja mesa utvrditi će se utjecaj načina i dužine zrenja mesa na fizikalno-kemijske procese u mesu, što će biti iskoristivo u unapređenju kakvoće mesa lokalnih pasmina i povećanju njihove kompetitivnosti. Projektom je predviđeno utvrđivanje stavova različitih društvenih skupina. Najvažnije postignuće predloženog projekta je utvrđivanje interakcije pasminskih genetskih i proizvodnih pokazatelja sa stavovima društvenih skupina.]]></summary_hr><summary_en><![CDATA[Most local breeds of domestic animals were neglected during the twentieth century, primarily because of their lower production competitiveness. Today, local breeds are valued by society as a valuable genetic and cultural heritage, important for the safety of food production, maintaining the distinctiveness of rural areas and biodiversity, without neglecting their current or potential economic importance. Some local breeds that have been brought to the brink of survival in recent decades and society seek to promote, through public funds, the development of sustainable production systems for endangered local breeds. Past experiences in developing sustainable systems for protecting local breeds emphasize the need for a balanced and multilateral focus on all conservation program participants. The proposed scientific research aims at the example of five Croatian local breeds (Istrian cattle, Busha, Littoral-Dinaric and Istrian donkey, Posavina horse) located in different geographical areas to identify genetic, economic and social indicators of local breeds and to identify interactions of established indicators. Pedigree record analysis, genotyping, and certain polymorphic gene loci will be used to evaluate genetic indicators. Production indicators will be evaluated by collecting phenotype descriptors, descriptors of carcass characteristics at the slaughter line and descriptors of meat quality. The analysis of the chemical meat composition and changes in the composition of fatty acids and amino acids during the ‘meat aging’ will determine the effect of the procedure and length of meat ageing on physico-chemical processes in meat. Outcomes will be useful in improving the meat quality of local breeds and increasing their competitiveness. The project envisages establishing the attitudes of social groups. The most important achievement of the proposed project is to determine the interaction of breed, genetic and production indicators with the attitudes of social groups.]]></summary_en></project><project>
<id>10186</id><title_hr><![CDATA[Prostorno-vremenska varijabilnost kopnenih i vodenih zajednica povremenih tekućica dinarskog krša ]]></title_hr><title_en><![CDATA[Spatio-temporal variability of terrestrial and aquatic communities in intermittent rivers in the Dinaric karst ]]></title_en><user_id>25628</user_id><user_firstLast_name>Andreja Brigić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2020-02</proposal_call><code>UIP-2020-02-5385</code><acronim><![CDATA[DinDRY]]></acronim><duration>23.02.2021 - 22.02.2027</duration><status>U tijeku</status><financ_value>265.437,88 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>25985, 26856, 26987, 866732, 24444, 869887, </team_members_id><team_members_names><![CDATA[Marina Vilenica, Fran Rebrina, Lea Ružanović, Iva Čupić, Zuzana Redžović, Nera Vuić, ]]></team_members_names><keywords_hr><![CDATA[raznolikost, suho riječno korito, disperzija, rekolonizacija, biološka procjena stanja]]></keywords_hr><keywords_en><![CDATA[diversity, dry riverbed,  dispersal, recolonization, bioassessment ]]></keywords_en><summary_hr><![CDATA[Prema trenutnom stanju u istraživanju, povremene tekućice (IRES), slabo prepoznate i od strane ekologa i vodnog gospodarstva, među najslabije su istraženim slatkovodnim ekosustavima, osobito u dinaridskoj regiji. To su hidrološki vrlo dinamični i složeni slatkovodni ekosustavi u kojima voda sezonski prestaje teći i oni presušuju. Nestalnost protoka, vidljiva u ciklusima presušivanja i ponovnog vlaženja, glavni je pokretač ekoloških procesa u IRES. Ona uzrokuje izmjenu vodenih i kopnenih faza, podržavajući mozaik lotičkih, lentičkih i kopnenih staništa. Stoga su organizmi u IRES prilagođeni na velike poremećaje u staništu, a sastavljeni su od vodenih, semiakvatičkih i kopnenih zajednica. One se izmjenjuju, koegzistiraju i nalaze u međusobnoj interakciji u prostoru i vremenu te ih karakterizira velik obrtaj vrsta. S obzirom na to, cilj ovog projekta je unaprijediti naše poznavanje IRES putem: I) razumijevanja uzoraka raznolikosti vodenih i kopnenih zajednica beskralješnjaka IRES, te II) otkrivanja uzoraka disperzije vodenih i kopnenih svojti u zajednicama IRES. Ovi ciljevi će biti ostvareni istovremenim uzorkovanjem vodenih i kopnenih zajednica te povezivanjem ekološkog, tzv. life history i molekularno genetičkog pristupa kako bi se ustanovili putevi rekolonizacije. Otkrivajući razlike u strukturi i sastavu zajednica između netaknutih i antropogeno utjecanih IRES, DinDRY će znatno povećati poznavanje uzoraka bioraznolikosti IRES i potencijalnih ugroza. Također će pružiti novi uvid u obrasce disperzije i funkcionalne raznolikosti specijalista za IRES. Temeljem prikupljenog znanja, DinDRY ima za cilj pružiti znanstvenu podlogu za metodologije biološke procjene, uzimajući u obzir i vodene i kopnene svojte. To će biti od iznimne važnosti za razvoj holističkog pristupa zaštiti i upravljanju ovim osjetljivim ekosustavima.]]></summary_hr><summary_en><![CDATA[Current state-of-the-art identifies intermittent rivers and streams (IRES), unrecognised by both ecologists and water managers, as being among the least studied freshwater ecosystems, especially in the Dinaric region. They are hydrologically highly dynamic and complex freshwater ecosystems, which seasonally cease to flow and run dry. Flow intermittence, evident in drying and rewetting events, is the main driver of ecological processes in IRES. It causes alternation of aquatic and terrestrial phases, supporting a habitat mosaic of lotic, lentic and terrestrial patches. Thus, IRES biota, adapted to extreme disturbance in their habitat, are composed of aquatic, semiaquatic and terrestrial communities. They alternate, coexist and interact in space and time, experiencing great species turnover. Accordingly, this project aims at advancing our knowledge on IRES by: I) understanding diversity patterns of aquatic and terrestrial invertebrate communities of IRES, and II) revealing dispersal patterns of aquatic and terrestrial taxa in IRES communities. These aims will be achieved by simultaneous sampling of aquatic and terrestrial communities and by combining the approaches of ecological, i.e. life history traits and molecular genetic analyses in order to determine recolonization pathways. By identifying differences in community structure and composition between pristine and anthropogenically impacted IRES, this project will substantially increase the knowledge on IRES biodiversity patterns and potential threats. It will also provide new insights into dispersal patterns and functional diversity of IRES specialists. Based on the obtained knowledge, the project aims to provide scientific background for bioassessment methodology, taking into account both aquatic and terrestrial taxa. This will be vital in enabling holistic approach in conservation and management of these vulnerable ecosystems.]]></summary_en></project><project>
<id>10187</id><title_hr><![CDATA[Interakcija koroninih šupljina i sunčevih oluja]]></title_hr><title_en><![CDATA[Interaction of COronal HOles and Solar Storms]]></title_en><user_id>6152</user_id><user_firstLast_name>Mateja Dumbović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2020-02</proposal_call><code>IP-2020-02-9893</code><acronim><![CDATA[ICOHOSS]]></acronim><duration>01.03.2021 - 28.02.2025</duration><status>Završio</status><financ_value>161.638,46 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Geodetski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Geodesy]]></institution_en><team_members_id>4850, 19704, 26665, 855869, 865321, 866192, 867647, </team_members_id><team_members_names><![CDATA[Bojan Vršnak, Manuela Temmer, Astrid Veronig, Karmen Martinić, Suresh Karuppiah, Akshay Kumar Remeshan, Galina Chikunova, ]]></team_members_names><keywords_hr><![CDATA[koronini izbačaji, koronine šupljine, korotirajuća područja interakcije, svemirska prognostika, fizika Sunca i Heliosfere]]></keywords_hr><keywords_en><![CDATA[coronal mass ejections, coronal holes, corotating interaction regions, space weather, solar and heliospheric physics]]></keywords_en><summary_hr><![CDATA[Koronini izbačaji (eng. Coronal mass ejections, CMEs), popularno zvane “Sunčevim olujama” najsilovitiji su eruptivni fenomeni u Sunčevom sustavu te su stoga u fokusu svemirske prognostike. Njihova interakcija s brzim tokovima koji potječu iz koronarnih rupa (eng. coronal hole, CH), regija niske gustoće plazme u sunčevoj koroni, može dovesti do još opasnijih poremećaja svemirskih vremenskih prilika. Cilj predloženog istraživanja je poboljšati razumijevanje interakcije CME-a i CH proučavanjem različitih tipova CME-CH interakcija, analizom udaljenosti interakcije i ako/kako CME-CH interakcija mijenja unutarnju magnetsku strukturu CME-a. Predlažemo da se to postigne opsežnom analizom CME-CH interakcija pomoću kombiniranog modeliranja i opservacijskog pristupa. Primijenit će se metode modeliranja „Sun-to-Earth“ u rasponu od CME 3D rekonstrukcije blizu Sunca, modeliranja propagacije i evolucije u heliosferi do in situ rekonstrukcije magnetske strukture. S druge strane, koristit će se opsežna opažanja različitih instrumenata na različitim  lokacijama u heliosferi, od EUV promatranja CME potpisa u niskoj sunčevoj koroni, opažanja koronagrafima, in situ i mjerenja na zemljinoj površini. Predložena istraživanja dovest će do dubljeg razumijevanja složenih sunčevih oluja, koje nisu rijetke pojave i mogu izazvati ozbiljne poremećaje svemirskih vremenskih prilika, posebice kod magnetski aktivnijih zvijezda od Sunca. Osim toga, poboljšat ćemo i dosadašnja znanja iz perspektive prognoziranja svemirskih vremenskih prilika, kako bi se ublažile štete vezane uz složene i, dakle, opasne poremećaje svemirskih vremenskih prilika.]]></summary_hr><summary_en><![CDATA[Coronal mass ejections (CMEs), popularly known as “Solar storms”, are the most violent eruptive phenomena in the solar system and most prominent drivers of the space weather. Their interaction with fast streams originating from coronal holes (CH), low-plasma density regions in the solar corona, can lead to even more hazardous space weather events. The proposed research aims to improve our understanding of the interaction of CMEs and CH and their (intensified) space weather effects by unravelling different types of CME-CH interactions, analysing the interaction distance and if/how the CME-CH interaction change the inner magnetic structure of the CME. We propose to achieve this through extensive analysis of CME-CH interactions using a combined modelling and observational approach. Modelling methods will be applied Sun-to-Earth ranging from CME 3D reconstruction close to the Sun, heliospheric propagation and evolution modelling to in situ reconstruction of the magnetic structure. On the other hand, extensive multi-spacecraft and multi-instrument observations will be used, ranging from EUV observation of the low coronal CME signatures, white-light observations, in situ and ground-based measurements. The proposed research will lead to a deeper understanding of complex solar storms, which are not are not uncommon phenomena and can cause severe space weather disturbances, even more so at magnetically more active stars. In addition, we will also improve our current knowledge from the perspective of forecasting space weather in order to mitigate damages related to complex and, hence, hazardous space weather events.]]></summary_en></project><project>
<id>10194</id><title_hr><![CDATA[Procjena konzervacijske obrade tla kao napredne metode uzgoja usjeva i prevencije degradacije tla]]></title_hr><title_en><![CDATA[Assessment of conservation soil tillage as advanced methods for crop production and prevention of soil degradation]]></title_en><user_id>20372</user_id><user_firstLast_name>Danijel Jug</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2020-02</proposal_call><code>IP-2020-02-2647</code><acronim><![CDATA[ACTIVEsoil]]></acronim><duration>22.12.2020 - 21.12.2024</duration><status>Završio</status><financ_value>169.752,47 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Fakultet agrobiotehničkih znanosti Osijek]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Agrobiotechnical Sciences in Osijek]]></institution_en><team_members_id>20373, 20374, 1289, 1279, 20345, 29276, 29748, 5755, 29289, 29290, 5692, 19626, 6022, 20511, 23441, 865146, 865145, 25960, </team_members_id><team_members_names><![CDATA[Irena Jug, Boris Đurđević, Bojana Brozović, Bojan Stipešević, Vesna Vukadinović, Darko Kiš, Boris Antunović Antunović, Olga Jovanović Glavaš, Branka Šakić Bobić, Zoran Grgić, Ivka Kvaternjak, Andrija  Špoljar, Davorka Hackenberger Kutuzović, Gabriella Kanižai Šarić, Marija Ravlić, Iva Rojnica, Larisa Bertić, Monika Marković, ]]></team_members_names><keywords_hr><![CDATA[Konzervacijska poljoprivreda, konzervacijska obrada tla, degradacija tla, disanje tla, fizika tla, kemija tla, biologija tla, ratarski usjevi]]></keywords_hr><keywords_en><![CDATA[Conservation agriculture, conservation soil tillage, soil degradation, soil respiration, soil physics, soil chemistry, soil biology, field crops]]></keywords_en><summary_hr><![CDATA[Istraživanja konzervacijskih sustava gospodarenja poljoprivrednim tlima, kao i pozitivni rezultati njihove primjene, u današnje vrijeme sve većih ekoloških, klimatskih, gospodarskih i drugih izazova, predstavljaju imperativ uspješne i održive poljoprivredne proizvodnje. Tlo se sve više apostrofira kao centar zbivanja i izvorište brojnih okolišno-antropogenih međusobno uvjetovanih interakcija. Degradacijom tla kao jednog od primarnih okolišnih integratora, pravilno funkcioniranje agroekološkog sustava postaje nestabilno i upitno. Cilj ovih istraživanja je utvrditi razinu degradacije odabranih sastavnica fizikalnog, kemijskog i biološkog kompleksa tla međusobnom usporedbom konvencionalnih i konzervacijskih sustava obrade tla. Isto tako, definiranje pozitivnih mjera i postupka za zaustavljanje, preveniranje i ublažavanje antropogenih i prirodnih degradacijskih procesa u tlu na različitim agroekološkim lokalitetima istraživanja, u velikoj mjeri može biti značajan za zaštitu okoliša, poljoprivredne proizvođače, znanstvenu i stručnu zajednicu, donosioce odluka, a svakako će poslužiti kao baza za daljnja znanstvena istraživanja.]]></summary_hr><summary_en><![CDATA[Research of conservation systems in agricultural soils management, as well as the positive results of their application, in light of present time&#39;s rise of environmental, climate, economic and other challenges, presents the utmost imperative for successful and sustainable agricultural production. The soil is increasingly being emphasized as the center of events and the source of numerous environmental-anthropogenic intertwined interactions. Due to soil degradation, one of the primal environmental integrators, the proper functioning of the agro-ecological system becomes unstable and questionable. The aim of these studies is to determine the level of degradation of selected components of the physical, chemical and biological soil complexes by comparison of conventional and conservation soil tillage systems. Also, defining positive measures and procedures for stopping, preventing and mitigating anthropogenic and natural degradation processes in the soil at different agro-ecological research sites will be of great pertinence to environmental protection, agricultural producers, scientific and professional community, decision-makers, and will certainly serve as a basis for further scientific research.]]></summary_en></project><project>
<id>10199</id><title_hr><![CDATA[Distribuirano upravljanje za dinamičko gospodarenje energijom u složenim sustavima naprednih gradova]]></title_hr><title_en><![CDATA[Distributed control for dynamic energy management of complex systems in smart cities]]></title_en><user_id>7616</user_id><user_firstLast_name>Vinko Lešić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2020-02</proposal_call><code>UIP-2020-02-9636</code><acronim><![CDATA[DECIDE]]></acronim><duration>01.01.2021 - 31.12.2025</duration><status>Završio</status><financ_value>248.191,65 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Temeljne tehničke znanosti, Elektrotehnika, </scie_field_hr><scie_field_en>Basic engineering sciences, Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>21402, 17458, 21403, 26872, 23948, 19265, 861739, 864958, 864957, 865255, 865476, 865475, </team_members_id><team_members_names><![CDATA[Mateja Car, Hrvoje  Novak, Nikola Hure, Danko Marusic, Filip Maletić, Anita Martinčević, Filip Vrbanc, Nikica Perić, Anđelko Kolak, Mihael Jakšić, Mia Baržić, Mojtaba Hajihosseini, ]]></team_members_names><keywords_hr><![CDATA[Distribuirano upravljanje, Modelsko prediktivno upravljanje, Sustavi klimatizacije u zgradi, Mikromreža, Smart city]]></keywords_hr><keywords_en><![CDATA[Distributed control, Model predictive control, Building HVAC system, Microgrid, Smart city]]></keywords_en><summary_hr><![CDATA[Zgrade kao najveći svjetski potrošači energije nedvojbeno ulaze u eru sveobuhvatnih promjena i multidisciplinarnih trendova pri čemu ICT nalazi plodno tlo kao integracijski put različitih tehnologija za povećanje energetske učinkovitosti, odnosno postizanja pozitivne ekonomske bilance. Glavni je cilj predloženog projekta razviti modularnu i skalabilnu integracijsku metodologiju za povezivanje različitih tehnologija i podsustava zasnovanu na dinamičkoj rekonfiguraciji obuhvaćenih podjedinica i komponenata (agenata) te distribuiranom optimalnom upravljanju. Pri tome svaka jedinica radi neovisno i nastoji postići minimalnu cijenu utrošene energije za vlastiti rad uzevši u obzir svoje postojeće stanje, buduće vrijednosti relevantnih veličina te matematičke modele unutarnjih procesa. Sve jedinice sustava zatim se kroz međusobno nadmetanje dovode u točku najveće moguće zajedničke uštede u radu, a učinkovitost algoritma omogućuje primjenu u stvarnom vremenu kao autonomni sustav automatizacije za optimalno gospodarenje energijom. Hijerarhijskim pristupom čuva se tehnološka i legislativna nezavisnost uz međusobnu razmjenu podataka svedenih na informacije o cijeni i potrošnji. Pristupom se postiže jednostavna nadogradnja i modularno uključenje novih podjedinica ili podsustava. U projektu se naglasak stavlja na zone (prostorije) i komponente mikromreže kao podjedinice podsustava koji zajedno čine sustav zgrade s pozitivnom energetskom bilancom. Metodologija će se ispitati u eksperimentalnom okruženju uredskih prostorija i dostupne mikromreže s proizvodnjom iz obnovljivih izvora energije i sustavima pohrane u okviru jednog kata nebodera Sveučilišta u Zagrebu Fakulteta elektrotehnike i računarstva. U drugom stadiju projekta, primjena metodologije proširuje se na sustave agregatora zgrada i električnih vozila prema konceptu naprednih gradova.]]></summary_hr><summary_en><![CDATA[Buildings, as the world’s biggest energy consumers, are undoubtedly entering an era of comprehensive changes and multidisciplinary trends where ICT is suitable as an integration tool for different technologies for increasing the energy efficiency, i.e., achieving the zero-energy level. The main objective of the proposed project is to research and develop modular and scalable integration methodology for connecting the different technologies and subsystems, based on dynamic reconfiguration of considered subunits and components (agents), and distributed optimal control. Each unit is thereby operating independently and strives to achieve the minimum cost of energy for its operation while taking into account its inner state, future values of relevant variables, and mathematical models of inner process. All the subunits are further taken, through mutual bidding, to the point of the maximum possible mutual operation savings, and algorithm efficiency enables real-time application as an autonomous automation system for optimum energy management. Hierarchical approach keeps the technological and legislative independency with mutual interchange of data reduced to prices and consumption information. Simple extension and modular inclusion of additional subunits or subsystems is achieved. The project is focused on zones (rooms) and microgrid components as subunits of the subsystems that together form a zero-energy building system. The methodology will be investigated in experimental environment of offices and available microgrid with renewably energy sources production and storage systems on a floor of the skyscraper building at University of Zagreb, Faculty of Electrical Engineering and computing. In the second stage of the project, the methodology is extended to building aggregator systems and electrical vehicles with corresponding infrastructure towards the smart city concept.]]></summary_en></project><project>
<id>10202</id><title_hr><![CDATA[Uloga mikrobiote u razvoju tumora mokraćnog mjehura]]></title_hr><title_en><![CDATA[Role of microbiota in bladder cancer development ]]></title_en><user_id>5769</user_id><user_firstLast_name>Janoš Terzić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2020-02</proposal_call><code>IP-2020-02-8921</code><acronim><![CDATA[µBC]]></acronim><duration>08.03.2021 - 07.03.2025</duration><status>Završio</status><financ_value>198.022,43 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Split School of Medicine]]></institution_en><team_members_id>5111, 22603, 19132, 1435, 4462, 571484, 865122, 869834, </team_members_id><team_members_names><![CDATA[Jelena Korać Prlić, Blanka Roje, Maria Bošković, Katarina Vilović, Marijan Šitum, Michael Zimmermann, Dora Knezović, Nives Matković, ]]></team_members_names><keywords_hr><![CDATA[mikrobiota, tumor, mokraćni mjehur, BCG, TLR4]]></keywords_hr><keywords_en><![CDATA[microbiota, cancer, urinary bladder, BCG, TLR4]]></keywords_en><summary_hr><![CDATA[Rak mokraćnog mjehura (BC) četvrti je najčešći karcinom kod muškaraca nakon karcinoma prostate, pluća i debelog crijeva. Tri je do četiri puta češći kod muškaraca nego kod žena. Rak mokraćnog mjehura može biti uzrokovan kroničnom infestacijom sa Schistosoma haematobium, dok glavni terapijski pristup koristi infekciju bakterijom Bacillus Calmette Guerin (BCG). Te činjenice jasno ističu važnost mikroba (mikrobiote) u patogenezi karcinoma mokraćnog mjehura. Nedavna istraživanja, uključujući i naša, pokazala su da urin nije sterilan, te postaje jasno da se razlikuje mikrobiota urina u pacijenata s BC-om i u zdravih osoba. Projetkom se planiraju istraživati tri važna elementa međuodnosa mikrobiote i raka mokraćnog mjehura. Prvo. Istraživati ćemo promjene u sastavu mikrobiote urina tijekom liječenja raka mjehura s BCG imunoterapijom. Iako je BCG uveden prije više od 40 godina, mehanizam njegovog djelovanja nije potpuno jasan. Većina studija istraživala je odgovor imunoloških i urotelnih stanica tijekom liječenja BCG-om, dok je mikrobiota mokraćnog mjehura uglavnom zanemarivana. Stoga planiramo pratiti promjene mikrobiote urina u pacijenata tijekom liječenja BCG-om i povezati te promjene s recidivom tumorske bolesti.Drugo, pomoću miševa s nefunkcionalnim TLR4 receptorom utvrditi ćemo ulogu gram-negativnih bakterija (koje sadrže lipopolisaharid, ligand za TLR4, poput Escherichia coli i Fusobacterium nucleatum) u razvoju raka mjehura.Treće, indukcijom BC-a u miševima bez mikroba (engl. germ free) proučiti ćemo ukupni doprinos čitave mikrobne zajednice razvoju BC-a. Proučavanjem bolesnika s rakom mjehura i mišjih modela za tu bolest, predloženi projekt ima za cilj utvrditi važne aspekte uloge koju mikrobiota ima u razvoju i recidiviranju BC-a. Identifikacija mikroba ili s mikrobima-povezanih molekularnih elemenata važnih za patologiju BC otvorilo bi nove mogućnosti u postavljanju dijagnoze, kao i u prevenciji i liječenju raka mokraćnog mjehura.]]></summary_hr><summary_en><![CDATA[Bladder cancer (BC) is the fourth most common cancer in men after prostate, lung and colorectal cancer. It is three to four times more common in males than in females. Bladder cancer can be caused by chronic infestation with Schistosoma haematobium while the main therapeutical approach for BC involves infection with bacterium BCG. These facts clearly emphasize the importance of urinary microbes (microbiota) in bladder cancer pathogenesis, which has not been addressed properly yet. Recent studies, including ours, demonstrated that urine is not sterile and it is becoming evident that urine microbiota differs between patients with bladder cancer and healthy individuals. Here we propose a study that will address three important aspect of the intricate relationship between microbiota and BC. Firstly, we will study changes in urine microbiota composition during BCG immunotherapy. Although BCG was introduced more than 40 years ago, the mechanism of its action is still not clear and most of the mechanistic studies aimed to clarify the immune and urothelial cell response, while contribution of bladder microbiota was largely overlooked. Thus, we plan to follow microbiota changes during BCG-treatment in human patients and to associate observed changes with tumor recurrence. Secondly, by using mice with non-functional TLR4 receptor we will assess the role of lipopolysacharide (ligand for TLR4) containing, Gram-negative bacteria (e.g. Escherichia coli and Fusobacterium nucleatum) in BC development. Thirdly, by inducing the BC in germ-free mice we will address the contribution of the whole microbial community to BC development. By studying BC patients and mice models, the proposed project aims to determine important aspects of the role played by microbiota in BC development and progression. Identification of microbial or microbe-associated molecular elements important in BC pathology will open new avenues for bladder cancer diagnostics as well as for BC prevention and treatment.]]></summary_en></project><project>
<id>10207</id><title_hr><![CDATA[Imobilizacija lipaza na funkcionalizirane nosače na bazi odabranih otpada iz poljoprivredno-prehrambene industrije]]></title_hr><title_en><![CDATA[Immobilization of Lipases on Functionalised Carriers Produced from Selected Agro-Food Industrial Waste]]></title_en><user_id>4306</user_id><user_firstLast_name>Sandra Budžaki</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2020-02</proposal_call><code>IP-2020-02-6878</code><acronim><![CDATA[ImoLipWaste]]></acronim><duration>18.01.2021 - 17.05.2025</duration><status>Završio</status><financ_value>131.942,86 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Prehrambena tehnologija, Biotehnologija, </scie_field_hr><scie_field_en>Food technology, Biotechnology, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Prehrambeno-tehnološki fakultet]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Food Technology]]></institution_en><team_members_id>333, 1185, 27343, 25444, 6951, 4062, 27109, 27216, 26888, 864995, </team_members_id><team_members_names><![CDATA[Ivica Strelec, Natalija Velić, Volker Hessel, Marta Ostojčić, Blanka Bilić Rajs, Marija Stjepanović, Zita Šereš, Nikola Maravić, Jovana Stanojev, Mirna Brekalo, ]]></team_members_names><keywords_hr><![CDATA[lipaze, imobilizacija, otpad poljoprivredno-prehrambene industrije, ljuska jaja, talog kave, ljuska crvenog luka]]></keywords_hr><keywords_en><![CDATA[lipase, immobilization, agro-food industry waste, eggshell, spent coffee ground, brown onion skin]]></keywords_en><summary_hr><![CDATA[Jedan od glavnih izazova održivog gospodarenja otpadom poljoprivredno-prehrambene industrije je primjena strategije kružnog gospodarenja po „zero-waste“ modelu uz razvoj inovativnih tehnika transformacije otpada u koje se svakako može ubrojiti transformacija u nosače pogodne za imobilizaciju enzima. Zamjenom kemijskih katalizatora imobiliziranim enzimima moguće je riješiti otvorena pitanja energetske učinkovitosti i ekološke prihvatljivosti, dok ekonomska isplativost procesa ovisi o cijeni imobiliziranih enzima. Mogu li se transformacijom otpada dobiti cjenovno prihvatljivi nosači koji će poslužiti za imobilizaciju lipaza kako bi se razvile imobilizirane lipaze visoko-poželjnih svojstava koje bi se dugoročno mogle primijeniti u biokatalitičkoj proizvodnji je pitanje na koje se ovim istraživačkim projektom želi dobiti odgovor.U tu svrhu prvo će se provesti priprema nosača na bazi odabranog otpada: ljuske jaja, taloga kave i ljuske crvenog luka, kako bi se dobili nosači poželjnih operativnih svojstava i visokog kapaciteta imobilizacije. Nakon toga uslijedit će imobilizacija lipaza iz Pseudomonas fluorescens i Burkholderia cepacia različitim tehnikama imobilizacije, a sve u svrhu dobivanja imobiliziranih lipaza najpoželjnijih svojstava i visokog potencijala za primjenu u biokatalitičkim procesima. Određivanje ključnih biokemijskih i operativnih svojstava slobodnih i imobiliziranih lipaza poslužit će kao kriteriji odabira najuspješnijih, čija će se operativna funkcionalnost provjeriti u reakcijama hidrolize, acidolize i transesterifikacije. Tehno-ekonomska analiza simulacije u industrijskom mjerilu i analiza životnog ciklusa dat će krajnji odgovor koje će od imobiliziranih lipaza biti dugoročno najisplativije i ekološki najprihvatljivije.]]></summary_hr><summary_en><![CDATA[One of the main challenges of the agro-food industry sustainable waste management by “zero-waste” model is the application of the circular management strategy, including development of innovative waste transformation techniques. Agro-food waste transformation into carriers for enzyme immobilization clearly represent one of such techniques, while replacement of chemical catalysts with immobilized enzymes might solve the issues of energy efficiency and environmental acceptability. On the other hand, process economic cost-effectiveness is highly dependent on the immobilized enzyme price. Whether the agro-food waste transformation could result with cost effective enzyme carriers for lipase immobilization, and subsequent development of immobilised lipases of desirable operational properties for use in the biocatalytic production, is the question this project aiming to answer.In this respect, carriers of desirable operational properties and high immobilization capacity will be prepared from selected waste: eggshells, spent coffee grounds and brown onion skin followed by subsequent immobilization of Pseudomonas fluorescens i Burkholderia cepacia lipases using various immobilization techniques. Biochemical and operational properties of free and immobilized lipases will be used for the selection of developed immobilized lipases of the greatest efficiency, which will be tested for operational functionality in the selected reactions of acidolysis, hydrolysis and transesterification. The final proof will be confirmed by industrial scale techno-economic analysis simulation, as well as life cycle analysis.]]></summary_en></project><project>
<id>10216</id><title_hr><![CDATA[Recikliranje aluminijevih legura u čvrstom i polučvrstom stanju]]></title_hr><title_en><![CDATA[Recycling of aluminium alloys in solid and semisolid state]]></title_en><user_id>5169</user_id><user_firstLast_name>Branimir  Lela</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2020-02</proposal_call><code>IP-2020-02-8284</code><acronim><![CDATA[ALURECSS]]></acronim><duration>25.01.2021 - 24.01.2025</duration><status>Završio</status><financ_value>110.637,73 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, Metalurgija, </scie_field_hr><scie_field_en>Mechnical engineering, Metallurgy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Fakultet elektrotehnike, strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Electrical Engineering, Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>832, 3263, 1133, 24032, 24059, 576, 29758, 867407, </team_members_id><team_members_names><![CDATA[Dražen Bajić, Sonja Jozić, Senka Gudić, Jure Krolo, Ivana Dumanić, Ladislav Vrsalović, Karla Grgić, Igor Ćulum, ]]></team_members_names><keywords_hr><![CDATA[Recikliranje aluminija, Metalne pjene, Thixo oblikovanje, Svojstva i obradivost recikliranih poluproizvoda, Matematičko modeliranje]]></keywords_hr><keywords_en><![CDATA[Aluminium recycling, Metal foams, Thixoforming, Properties and machinability of recycled semi-finished products, Mathematical modeling]]></keywords_en><summary_hr><![CDATA[Recikliranje aluminija kao drugog najčešće korištenog metala je izrazito važno za očuvanje okoliša, ali i za cirkularnu ekonomiju u aluminijskoj industriji. Aluminij se može neograničeno reciklirati bez gubitaka kvalitete materijala i postoji potreba za razvojem novih tehnologija i strategija na području recikliranja s ciljem povećanja iskorištenja nastalog otpada, ali i smanjenja ispuštanja štetnih plinova u atmosferu te utjecaja na okoliš. Kao jedna od novijih tehnologija na području recikliranja je i recikliranje metala bez pretaljivanja. Ovakav postupak smatra se energetski učinkovitijim od konvencionalnog i sa značajno manjim ispuštanjem ugljikovog dioksida u okoliš, a osim uštede energije bolji je i stupanj iskorištenja materijala u odnosu na konvencionalno recikliranje. Predloženo istraživanje temelji se na razvoju i analizi naprednih tehnika recikliranja aluminijskog otpada u cilju omogućavanja izrade metalnih pjena u čvrstom ili polučvrstom stanju te s ciljem dobivanja kvalitetnog homogenog sirovca za thixo oblikovanje (thixo sirovca). Posebnost navedenih tehnika je izrazito visok stupanj iskorištenja materijala u usporedbi s konvencionalnim tehnikama recikliranja. Također, primjenom spomenutih tehnika energetske uštede bile bi značajne, te kao takve i zanimljive široj publici na globalnoj razini. Cilj istraživanja je eksperimentalno potvrditi, matematički modelirati i optimirati proces dobivanja metalnih pjena u čvrstom ili polučvrstom stanju te proces dobivanja homogenog sirovaca za thixo oblikovanje koristeći metalni otpad kao bazni materijaluz minimalni utrošak energije i postizanje maksimalnih mehaničkih svojstava. Nakon recikliranja provelo bi se istraživanje obradivosti tako dobivenog materijala što je izrazito bitno za komercijalnu upotrebu naprednih tehnika recikliranja.]]></summary_hr><summary_en><![CDATA[Recycling of aluminium as the second most commonly used metal is of extreme importance both for environment protection and the circular economy in the aluminium industry. Aluminium can be recycled indefinitely without quality deterioration of the material. There is a grow ing need for development of new recycling technologies and strategies with the aim of increasing the recovery rate for recycling of produced w aste, as well as reduction of emissions of harmful pollutants into the atmosphere and mitigation of adverse environmental impact. Recycling of material without remelting is one of recent recycling technologies. Compared to the standard process, energy efficiency is considered to be higher, with significantly lower emissions of carbon dioxide into the environment. Apart from energy savings, the efficiency level of using the material is higher, compared to traditional methods. Proposed research is based on development and analysis of advanced methods of recycling aluminium waste with the aim of producing metal foams in solid and semisolid state and high-quality homogenous precursor material for thixoforming (thixo feedstock). The specific feature of these methods is extremely high yield, compared to standard recycling methods. Moreover, the application of mentioned methods w ould result in significant energy savings, raising interest of w ider population at a global level. The goal of the research is to experimentally confirm, create mathematical models and optimise the process of obtaining metal foams in solid and semisolid state and the process of obtaining homogenous precursor material for thixoforming, using metal chips as base material, with minimum energy consumption and obtaining maximum level of mechanical properties. After the recycling process, the next stage w ould be investigating the machinability of material obtained in the process, which is particularly important for commercial applications of advanced recycling methods.]]></summary_en></project><project>
<id>10218</id><title_hr><![CDATA[Emergentni i zapostavljeni hepatotropni virusi nakon transplantacije solidnih organa i krvotvornih matičnih stanica]]></title_hr><title_en><![CDATA[Emerging and neglected hepatotropic viruses after solid organ and hematopoetic stem cell transplantation]]></title_en><user_id>4149</user_id><user_firstLast_name>Anna Mrzljak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2020-02</proposal_call><code>IP-2020-02-7407</code><acronim><![CDATA[HepViroTransplant]]></acronim><duration>01.01.2021 - 31.12.2024</duration><status>Prekinut</status><financ_value>199.024,49 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Clinical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>2546, 13626, 29273, 29268, 29288, 19353, 2676, 3103, 29745, 19086, 29267, 29750, 4211, 4371, 6975, 19530, 2599, 861626, 19394, 24127, </team_members_id><team_members_names><![CDATA[Lorena Jemeršić, Željka Jureković, Manuela Miletić, Danko Mikulić, Karla Mišura Jakobac, Slobodanka Ostojić Kolonić, Nenad Pandak, Vladimir Savić, Ana Jelić, Tatjana Vilibić Čavlek, Jadranka Pavičić Šarić, Maja Ilić, Maja Bogdanić, Ljubo Barbić, Adriana Vince, Vladimir Stevanović, Jelena Prpić, Željka Hruškar, Irena Tabain, Bojana Šimunov, ]]></team_members_names><keywords_hr><![CDATA[hepatotropni virus, transplantacija bubrega, transplantacija jetre, transplantacija krvotvornih matičnih stanica, molekularna dijagnostika]]></keywords_hr><keywords_en><![CDATA[hepatropic virus, kidney transplantation, liver transplantation, hematopoetic stem cell transplantation, molecular diagnostic]]></keywords_en><summary_hr><![CDATA[Uzročnici humanog virusnog hepatitis obuhvaćaju širok raspon patogena, osim klasičnih hepatotropnih virusa hepatisa A-E. Zapostavljeni sekundarni hepatotropni virusi (HV) poput humanih herpes virusa 6/7 (HHV-6, HHV-7), parvovirusa B19 (B19V), bocavirusa (HBoV) mogu uzrokovati ozljedu jetre u rasponu od blagog do fulminantnog hepatitisa. U narušenom imunološkom sustavu, poput onog kod osoba nakon transplantacije solidnih organa (TSO) ili krvotovornih matičnih stanica (TKMS) navedeni virusi mogu imati specifične učinke i/ili uzrokovati produženu i diseminiranu bolest. Ulogu torque-teno virusa (TTV), SEN virusa (SENV), humanog pegivirusa (HPgV) i hepacivirusa ne-primata (NPHV) kao jetrenih patogena ostaje također za razjasniti. Budući da Hrvatska ima visoku TKMS aktivnost i jednu od najviših stopa transplantacije jetre (32.20 pmp) i bubrega (43.40 pmp) na svijetu, od izrazite je važnosti istražiti učinak sekundarnih HV u kontekstu ishoda transplantacije.Ovo prospektivno istraživanje uključiti će kandidate za TSO (jetra/bubreg) i TKMS kako bi se utvrdila prevalencija 9 emergentnih i zapostavljenih virusa (HEV, HHV-6, HHV-7, B19V, HBoV, TTV, SENV, HPgV, HPHV) prije i tijekom prve godine nakon transplantacije, detekcijom virusne DNA/RNA i specifičnih antitijela. Eksplantirani jetreni uzorci također će biti testirani. Važno je naglasiti da sekundarni HV nisu dio rutinskih kliničkih testova, stoga je njihova epidemiologija u regiji nepoznata. Ovo istraživanje definirati će epidemiologiju, kliničke karakteristike i učinak HV prije i nakon transplantacije s ciljem unaprjeđenja ishoda transplantacije. Detekcija i genetska karaterizacija novih HV omogućiti će bolje razumijevanje epidemiologije virusnih hepatitisa u Hrvatskoj ali i jugoistočnoj Europi te stvoriti osnovu za unapređenje javnozdravstvenih mjera i zbrinjavanja nakon transplantacije.]]></summary_hr><summary_en><![CDATA[Human viral hepatitis results from a wide range of pathogens beyond the classic hepatotropic viruses such as hepatitis A-E. Neglected secondary hepatotropic viruses (HVs) such as human herpes viruses 6/7 (HHV-6, HHV-7), parvovirus B19 (B19V), bocavirus (HBoV) may cause hepatic injury ranging from mild to fulminant hepatitis. In the impaired immunological setting such as in patients after solid-organ transplantation (SOT) or after hematopoetic stem cell transplantation (HSCT), they may have particular effects and result in prolonged and disseminated disease. Several candidate viruses remain to be investigated as possible liver pathogens including torque-teno virus (TTV), SEN virus (SENV), human pegivirus (HPgV) and non-primate hepaciviruses (NPHV). Given the fact that Croatia has a high HSCT activity and one of the highest liver (32.20 pmp) and kidney (43.40 pmp) transplantation rates in the world, it would be of particular importance to investigate the impact of HVs in the context of transplantation outcomes.This prospective study will include SOT (liver/kidney) and HSCT candidates in order to identify the prevalence of nine emerging and neglected hepatotropic viruses (HEV, HHV-6, HHV-7, B19V, HBoV, TTV, SENV, HPgV, NPHV) before and within the first after transplantation by detection of viral DNA/RNA and specific antibodies. The explanted liver samples will be also tested. It is important to note that secondary HVs are not included in routine diagnostic testing, therefore, there are no data regarding the epidemiology in the region. The study will define the epidemiology, clinical characteristics and impact of HVs in pre- and post-transplant setting, with the intention to improve transplant outcomes. Detection and genetic characterization of new HVs will enable better understanding of the epidemiology of viral hepatitis in Croatia and in the South-East Europe which will set a platform to improve public health measures and post-transplant management.]]></summary_en></project><project>
<id>10221</id><title_hr><![CDATA[Afektivna multimodalna interakcija temeljena na konstruiranoj robotskoj spoznaji]]></title_hr><title_en><![CDATA[Affective Multimodal Interaction based on Constructed Robot Cognition]]></title_en><user_id>7444</user_id><user_firstLast_name>Tomislav Stipančić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2020-02</proposal_call><code>UIP-2020-02-7184</code><acronim><![CDATA[AMICORC]]></acronim><duration>01.02.2021 - 31.01.2026</duration><status>U tijeku</status><financ_value>189.954,54 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Interdisciplinarne tehničke znanosti, Elektrotehnika, Računarstvo, Strojarstvo, </scie_field_hr><scie_field_en>Interdisciplinary technological sciences, Electrical engineering, Computer sciences, Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>864994, 869849, 872809, </team_members_id><team_members_names><![CDATA[Leon Koren, Matija Zidarić, Sanja Miklin, ]]></team_members_names><keywords_hr><![CDATA[umjetna inteligencija, afektivna robotika, autonomni sustavi, multimodalna interakcija, interakcija robota i čovijeka]]></keywords_hr><keywords_en><![CDATA[artificial intelligence, affective robotics, autonomous systems, multimodal interaction, human-robot interaction]]></keywords_en><summary_hr><![CDATA[AMICORC će istražiti recentna istraživanja o ljudskoj spoznaji, kognitivnoj robotici te interakciji čovjeka i robota, te koristiti te spoznaje kao osnovu za razvoj novih strategija interakcije. Računalna arhitektura razvijena u AMICORC-u će se moći shvatiti kao pretvornik konteksta u podatke kao formu koja je razumljiva strojevima na temelju stalnih promjena u perspektivi. AMICORC će rezultirati Teorijom konstruirane robotske spoznaje (TCRC) koja će biti nova teorija informacija i okvir za integriranje ljudskih, robotskih i okolišnih perspektiva za interakciju i prilagodbu robota te njegovo okolišno utjelovljenje. Takve će se perspektive stalno mijenjati kroz interakciju unutar zajedničkog okruženja temeljem novih, nedostatnih i/ili djelomičnih informacija. AMICORC će rezultirati promjenom paradigme, odmakom od čistih podataka koji su prikupljeni senzorima prema kontekstualnoj percepciji.Za potrebe ove studije, četiri različita izvora socijalnih signala analizirat će se kroz multimodalnu interakciju, uključujući: prepoznavanje emocija lica, određivanje glasnoće u prostoriji, intenzitet pokreta tijela te analizu osjećaja kroz govor. Na ovaj će način sustav interpretirati socijalne signale kako bi stvorio hipoteze i odaslao neverbalne signale koristeći tehnike vizualizacije informacija osobi u interakciji. Kao dokaz koncepta, cjelokupna metodologija će biti implementirana i testirana u nekoliko scenarija na stvarnom robotu, te uronjenom i virtualnom agentu. Tijekom eksperimenata nastavnik će moći prilagoditi stil prezentacije i postići bolje približavanje studentu. Procjena upotrebljivosti temeljit će se na pristupu Wizard of Oz, koji će omogućiti učitelju interakciju s učenicima kroz robotsko sučelje. Ugrađene funkcionalnosti pružit će stupanj situacijske utjelovljenosti, samorazjašnjivosti i interakcije. Planirano istraživanje pokazat će na koji način i u kojoj mjeri kognitivni robot može biti stvarno učinkovit u tehnološki poboljšanom učenju.]]></summary_hr><summary_en><![CDATA[AMICORC will analyze recent research findings in human cognition, cognitive robotics and human robot interaction, and use them as the basis for developing new robot reasoning and interaction strategies. Computational architecture developed in AMICORC could be seen as context-to-data interpreter that endow machines to “reason” based on constantly changing perspectives. AMICORC will output the Theory of Constructed Robot Cognition (TCRC) as a new theory of information and generic framework for integrating human, robot and environmental perspectives on robot embodiment, interaction and adaptation. Such perspectives will change constantly through interaction within shared environment based on newly acquired, insufficient of partial information. AMICORC will result in a paradigm shift, moving away from sensed data toward contextual anticipation. For the purposes of this study, four distinct sources of social signals will be analyzed in multimodal interaction, including: face emotion recognition, level of loudness in the room, intensity of body movements and sentiment analysis applied on speech. In this way, the system will interpret social signals to generate hypotheses and output non-verbal signals using information visualization techniques to the person in interaction. As a proof-of-concept, the overall methodology will be implemented and tested in couple of testing scenarios on real, augmented or virtual social robot. During the experiments the teacher will be able to adapt the presentation style and achieve better rapport with the student. Usability evaluation will be based on the Wizard of Oz approach, allowing a teacher to interact with students through a robotic interface. Built-in functionalities of the robot will provide a degree of situational embodiment, self-explainability and context-driven interaction. The planned research will show in what way and to what extent a cognitive robot can be truly effective in technology-enhanced learning.]]></summary_en></project><project>
<id>10226</id><title_hr><![CDATA[Molekularna raznolikost virusa Epstein-Barr]]></title_hr><title_en><![CDATA[Molecular diversity of Epstein-Barr virus]]></title_en><user_id>4080</user_id><user_firstLast_name>Snježana Židovec Lepej</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2020-02</proposal_call><code>IP-2020-02-8961</code><acronim><![CDATA[MRVEB / MDEBV]]></acronim><duration>30.01.2020 - 29.01.2025</duration><status>Završio</status><financ_value>129.404,61 eur</financ_value><scie_area_hr>Prirodne znanosti, Biomedicina i zdravstvo, Interdiciplinarne znanosti, Biotehničke znanosti, Tehničke znanosti, </scie_area_hr><scie_area_en>Natural sciences, Biomedicine and health sciences, Interdisciplinary scientific area, Biotechnical sciences, Technological sciences, </scie_area_en><scie_field_hr>Biologija, Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Biology, Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Klinika za infektivne bolesti "Dr Fran Mihaljević", Zagreb]]></institution_hr><institution_en><![CDATA[Clinic for Infective Diseases "dr. Fran Mihaljević", Zagreb]]></institution_en><team_members_id>4779, 2902, 23837, 3204, 26586, 23906, 3952, 26598, 1497, 865084, 865070, 865072, 3951, 865045, 25214, </team_members_id><team_members_names><![CDATA[Goran Tešović, Renata Laškaj, Katarina Horvat Pavlov, Slavko Gašparov, Ante Šokota, Jelena Budimir Mihalić, Lana Gorenec, Laura Prtorić, Petra Korać, Lea Hosnjak, Maja Lunar, Mario Poljak, Ivana Grgić, Marija Rozman, Anita Stojanović Marković, ]]></team_members_names><keywords_hr><![CDATA[virus Epstein-Barr, virologija, molekularna raznolikost, sekvenciranje, infekcijska mononukleoza]]></keywords_hr><keywords_en><![CDATA[Epstein-Barr virus, virology, molecular diversity, sequencing, infectious mononucleosis]]></keywords_en><summary_hr><![CDATA[Epstein-Barr virus (EBV) ili humani herpesvirus 4 je ubikvitarni vlrus koji pripada porodici Herpesviridae. Akutna EBV infekcija može se prezentirati kao infekcijska mononukleoza, dok je latentna infekcija ovim virusom povezana s nastankom malignih bolesti. Specifični antivirusni lijekovi te cjepivo protiv EBV-a za sada nisu dostupni. Literaturni podatci o molekulamoj raznolikosti EBV-a i povezanosti genetske varijabilnosti virusa s patogenezom različitih bolesti vrlo su oskudni. Cilj ovog istraživanja je analizirati distribuciju genotipova, podtipova i genskih varijanti podtipova EBV-a u osoba s infekcijskom mononukleozom i malignim bolestima te istražiti moguću kliničku značajnost raznolikosti ovog virusa. Glavne hipoteze ovog istraživanja su: (1) zastupljenost genskih varijanti EBV-a s karakterističnim obrascima nukleotidnih promjena na razini gena EBNA-1, EBNA-2, LMP-1, Zp i BLLF1 u bolesnika s infekcijskom mononukleozom i u osoba s malignim bolestima je različita te (2) molekularna raznolikost EBV-a povezana je s težinom kliničkog tijeka infekcijske mononukleoze. Molekularna raznolikost EBV-a na razini odabranih gena analizirat će se primjenom populacijskog kao i dubinskog sekvenciranja, u svrhu otkrivanja koinfekcija s rijetkim molekularnim varijantama virusa. Metodom direktnog sekvenciranja u stvarnom vremenu optimizirat će se metoda analize cjelokupnog genoma ovog virusa. Predloženi projekt značajno će unaprijediti postojeća znanja o molekularnoj raznolikosti EBV-a na razini genotipova, podtipova i genskih varijanti virusa. Istraživanje molekularne raznolikosti ovog virusa u infekcijskoj mononukleozi i malignim bolestima povezanim s EBV-om omogućit će pručavanje moguće povezanosti između varijabilnsoti pojedinih virusnih gena i relevantnih kliničkih parametara. Nova znanja o molekularnoj raznolikosti EBV-a mogla bi značajno pridonijeti razvoju novih generacija cjepiva protiv EBV-a te boljem razumijevanju patogeneze bolesti povezanih s ovim virusom. ]]></summary_hr><summary_en><![CDATA[Epstein-Barr vlrus (EBV) or human herpesvirus 4 (HHV-4) is a ubiquitous virus belonging to the family Herpesviridae. Acute EBV infection is assoctated with development of infectious mononucleosis. Latent EBV infection is associated with development of malignancies. Specific antiviral drugs as well as EBV vaccines are currently not available. Literature data on EBV molecular diversity and association between viral genetic variations and pathogenesis of various diseases associated with this virus are limited. The aim of this study is to analyse EBV genotypes, subtypes and subtype genetic variants in patients with infectious mononucleosls and malignant diseases associated with EBV and to investigate the possible clinical significance of EBV genetic diversity. The main hypotheses of this study are: (1) the frequency of EBV characteristic combinations of variants in EBNA-1, EBNA-2, LMP-l, Zp and BLLF1 genes in patients with infectious mononucleosis and malignant diseases is different and (2) EBV molecular diversity in patients with infectious mononucleosis is associated with the clinical severity of disease. Molecular diversity of selected EBV genes will be analysed by population-based and ultra-deep sequencing probably leading to the more extensive analysis of co-infections with rare viral variants. Direct DNA sequencing in real time will be used for the whole genome analysis of EBV. The project is expected to significantly contribute to the knowledge on EBV molecular diversity by characterising viral genotypes, subtypes and subtype variants. EBV molecular diversity in infectious mononucleosis and malignant diseases will be considered in the context of the clinical presentation of diseases. Extensive analysls of EBV molecular diversity might significantly contribute to the development of EBV vaccines and improved understanding of the pathogenesis of disseases assoclated with EBV. ]]></summary_en></project><project>
<id>10229</id><title_hr><![CDATA[Ususret novoj direktivi Europske unije o upravljanju kvalitetom vode za kupanje ]]></title_hr><title_en><![CDATA[Towards the New European Union Bathing Water Directive ]]></title_en><user_id>204</user_id><user_firstLast_name>Slaven Jozić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2020-02</proposal_call><code>IP-2020-02-1880</code><acronim><![CDATA[EUROBATH]]></acronim><duration>01.01.2021 - 31.12.2024</duration><status>Završio</status><financ_value>71.751,14 eur</financ_value><scie_area_hr>Prirodne znanosti, Biomedicina i zdravstvo, Tehničke znanosti, </scie_area_hr><scie_area_en>Natural sciences, Biomedicine and health sciences, Technological sciences, </scie_area_en><scie_field_hr>Interdisciplinarne prirodne znanosti, Biologija, Računarstvo, Javno zdravstvo i zdravstvena zaštita, </scie_field_hr><scie_field_en>Interdisciplinary natural sciences, Biology, Computer sciences, Public health and health services, </scie_field_en><institution_hr><![CDATA[Institut za oceanografiju i ribarstvo]]></institution_hr><institution_en><![CDATA[Institute of Oceanography and Fisheries]]></institution_en><team_members_id>172, 5702, 27070, 29512, 407, 29505, 29514, 29491, 29474, 29543, 13683, 867520, </team_members_id><team_members_names><![CDATA[Mladen Šolić, Darija Vukić Lušić, Marin Glad, Arijana Cenov, Marin Ordulj, Anita Vucić, Tatjana Puljak, Dolores Grilec, Danijela Peroš-Pucar, Damir Ivanković, Jerko Hrabar, Jelena Čulić Gambiroža, ]]></team_members_names><keywords_hr><![CDATA[Voda za kupanje, javno zdravstvo, upravljanje kvalitetom vode, program praćenja, EU direktiva]]></keywords_hr><keywords_en><![CDATA[Bathing water, public health, water quality management, monitoring program, EU directive]]></keywords_en><summary_hr><![CDATA[Porastom morskog i obalnog turizma, sve veći pritisak na obalna područja rezultirao je povećanim rizikom od infekcija povezanih s aktivnostima kupanja. Učinkovitost praćenja kvalitete vode za kupanje od iznimne je važnosti za zaštitu kupača od bolesti povezanih s kupanjem. Da bi se postigao glavni cilj EU Direktive o upravljanju kvalitetom vode za kupanje (BWD, 2006/7/EC), zaštita zdravlja ljudi, važno ju je povremeno ažurirati na temelju dostupnih znanstvenih saznanja. Prepoznato je nekoliko slabosti trenutne Direktive, kao što su najmanji broj uzoraka potrebnih za pouzdanu klasifikaciju, utjecaj položaja uzorkovanja i prostorno-vremenskih razlika u kvaliteti vode na učinkovitost programa praćenja, granične vrijednosti indikatorskih bakterija za kategorije kvalitete vode, razvoj pouzdanih modela predviđanja kakvoće vode radi dobivanja pravovremenih podataka o kvaliteti vode, itd. Da bismo doprinijeli rješavanju ovih pitanja, provest ćemo primijenjeno istraživanje u kojem ćemo proučavati kvalitetu vode za kupanje na 22 plaže u pet obalnih područja duž hrvatske obale Jadrana. Znanstvenim pristupom čimbenicima koji utječu na sudbinu i raspodjelu indikatorskih bakterija u morskoj vodi, utvrdit ćemo učinak najvažnijih čimbenika koji utječu na prostorno-vremensku varijabilnost koncentracija indikatorskih bakterija na mjestima kupanja i na promjenu omjera između koncentracija E. coli i crijevnih enterokoka u morskoj vodi. Analizirajući više od 45000 prikupljenih podataka o kvaliteti vode, riješit ćemo uočenu neusklađenost između graničnih vrijednosti dviju indikatorskih bakterija za sve kategorije kakvoće vode u nacionalnom zakonodavstvu te opravdanost povećanja broja uzoraka po sezoni kupanja. Kao rezultat intenzivnog uzorkovanja i novog pristupa temeljenog na znanju o prostorno-vremenskim varijacijama koncentracija indikatorskih bakterija, razvit ćemo pouzdan model predviđanja kvalitete vode na području sa značajnim varijacijama u kvaliteti vode.]]></summary_hr><summary_en><![CDATA[As a marine and coastal tourism grew, a higher pressure on coastal areas resulted in an increased risk of waterborne infections connected to bathing activities. The efficacy of the monitoring of bathing water quality is of utmost importance for the protection of bathers from waterborne diseases. To achieve the main aim of the EU Bathing Water Directive (BWD, 2006/7/EC), the protection of human health, it is important to periodically update BWD based on up to date scientific knowledge. Several weaknesses of the current BWD have been recognized, such as the minimum number of samples needed for reliable classification, the effect of sampling point position and spatio-temporal variations in water quality on the efficacy of monitoring program, faecal indicator bacteria (FIB) limit values for water quality categories, the development of reliable water quality prediction models to obtain timely information on water quality, etc. To contribute in solving these issues, we will carry out applied research in which we will study bathing water quality at 22 bathing sites in five coastal areas along the Croatian Adriatic coast. By a scientific approach to factors affecting faecal indicator bacteria fate and distribution in seawater, we will determine the effect of the most important factors affecting spatio-temporal variability in FIB concentrations at bathing sites and on change in E. coli to intestinal enterococci concentrations ratio in marine water. By analysing more than 45000 collected data on water quality, we will solve both issues, the observed mismatch between limit values of two indicator bacteria for all water quality categories in national legislation and the justification of increase in the number of samples per season. As a result of intensive sampling and a new approach based on the knowledge on spatio-temporal variations in FIB concentrations, we will develop a reliable water quality prediction model in the area with significant variations in water quality.]]></summary_en></project><project>
<id>10234</id><title_hr><![CDATA[Održivo ribarstvo: društveni odnosi, identitet i zajedničko upravljanje jadranskim ribolovnim resursima]]></title_hr><title_en><![CDATA[Sustainable fishing: social relations, identity and co-management of Adriatic fishery resources ]]></title_en><user_id>29769</user_id><user_firstLast_name>Bruna Petani</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2020-02</proposal_call><code>UIP-2020-02-2238</code><acronim><![CDATA[SOCFISH]]></acronim><duration>22.02.2021 - 21.02.2026</duration><status>U tijeku</status><financ_value>188.294,51 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Sociologija, Politologija, Interdisciplinarne društvene znanosti, </scie_field_hr><scie_field_en>Sociology, Political Science, Interdisciplinary social sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zadru]]></institution_hr><institution_en><![CDATA[University of Zadar]]></institution_en><team_members_id>22625, 19080, 13384, 13296, 855366, 865436, 21073, </team_members_id><team_members_names><![CDATA[Mario  Katić, Ivan Puzek, Branko Ančić, Sven Marcelić, Danijel Kanski, Mislav Škacan Škacan, Dražen Cepić, ]]></team_members_names><keywords_hr><![CDATA[upravljanje prirodnim resursima, ribarstvo, socijalna ekologija, održivost, identitet]]></keywords_hr><keywords_en><![CDATA[natural resource management, fisheries, social ecology, sustainability, identity]]></keywords_en><summary_hr><![CDATA[Premda su zdravi oceani i ribarstvo ključni za život, opskrbu hranom te gospodarenje morem, procjenjuje se da je trećina procijenjenih globalnih ribljih stokova prekomjerno izlovljena. To čini istraživanja održivog ribolova izuzetno aktualnima i važnima. Predloženo istraživanje temelji se na aktualnim trendovima u istraživanju ribarstva: proučavanju normativnih aspekata, mentalnih modela, identiteta i društvenih mreža. Dok se istraživanje ribarstva u Hrvatskoj dosad gotovo isključivo temeljio na prirodnim znanostima, predloženi istraživački projekt pomogao bi uspostaviti sociološko istraživanje ribarstva kao novo i vrijedno područje istraživanja. Predloženo istraživanje temelji se na upotrebi mješovitih metoda, koje uključuje kombinaciju kvalitativnih i kvantitativnih metoda prikupljanja podataka: analize javnih politika, dioničke analize, anketnog istraživanja, analize društvenih mreža, etnografije, polu-strukturiranih intervjua te fokusnih grupa.  Ove metode će se koristiti za proučavanje morskog ribarstva na hrvatskoj obali Jadrana. Fokus će biti na komercijalnom ribarstvu, posebno industrijskom i malom ribarstvu. Međutim kako bi se istražila složenost ribolovnog sustava, u istraživanju će također biti zahvaćeni segmenti koje je teško odvojiti od komercijalnog ribolova, poput akvakulture i rekreacijskog ribolova.]]></summary_hr><summary_en><![CDATA[Healthy oceans and fisheries are essential for life and the provision of food, livelihoods and a strong marine economy, and yet it is estimated that a third of assessed global fish stocks are overfished. This makes research on sustainable fishing extremely timely and important. The proposed research builds on current trends in fishery research: the study of normative aspects of fishing, mental models, identities and social networks. While fishery science in Croatian academia has been based on life sciences, the proposed research project would help establish the social scientific exploration of fisheries as a new and valuable area of research. The proposed research is based on a mixed methods research design, involving a combination of qualitative and quantitative data-collection methods: policy analysis, stakeholder analysis, survey research, social network analysis, ethnography, semi-structured interviews, and focus group discussions. These methods will be used to study marine fisheries on the Croatian coast of the Adriatic The focus will be on commercial capture fisheries, in particular industrial and small-scale fisheries. However, in order to capture the complexity of the fisheries system, the research will also look at fisheries segments which can be difficult to isolate from commercial capture fisheries, such as aquafarming and recreational fishing. ]]></summary_en></project><project>
<id>10242</id><title_hr><![CDATA[Sistematika mehanizama u bezotopinskoj ili  tekućinski kataliziranoj sintezi u čvrstom stanju]]></title_hr><title_en><![CDATA[Mechanistic systematics for solvent-free or  liquid-catalysed solid-state synthesis]]></title_en><user_id>625</user_id><user_firstLast_name>Ivan Halasz</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2020-02</proposal_call><code>IP-2020-02-1419</code><acronim><![CDATA[SystForSynt]]></acronim><duration>01.01.2021 - 31.12.2024</duration><status>Završio</status><financ_value>169.885,19 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>463, 21253, 865094, 866586, </team_members_id><team_members_names><![CDATA[Goran Miletić, Stipe Lukin, Leonarda Vugrin, Ivica Cvrtila Cvrtila, ]]></team_members_names><keywords_hr><![CDATA[mechanochemistry, reaction mechnism, in situ monitoring, Hammett correlation, catalysis]]></keywords_hr><keywords_en><![CDATA[mehanokemija,  reakcijski mehanizam, in situ monitoring, Hammettova korelacija, kataliza]]></keywords_en><summary_hr><![CDATA[Istraživanje kemijskih transformacija mehaničkim mljevenjem rastuće je područje kemije i znanosti o materijalima, a opseg takvih reakcija ubrzano se širi. Provođenje mehanokemijskih reakcija u zatvorenim reakcijskim posudama, međutim, ograničava istraživanje njihova tijeka, pa su stoga njihovi mehanizmi uglavnom nepoznati. Projektni prijedlog SystForSynt usmjeren je na rješavanje ovog problema prvenstveno u području organskih reakcija. Predlažemo istraživanje u četiri radna paketa, koje smatramo vrlo značajnima, a uključuju provjeru Hammettove korelacije, razumijevanje tekućinske katalize u tekućinski-potpomognutim mehanokemijskim reakcijama, prenosivost mljevenja na ekstruziju i dinamiku atomskog i molekularnog izmjenjivanja mljevenih čestica i konačno, organske reakcije pregradnje te radikalske reakcije. Da bi se to postiglo, projekt SystForSynt primijenit će tehnike praćenja tijeka reaccije in situ, a koje se temelje na Ramanovoj spektroskopiji i rendgenskoj difrakciji na prahu, koje osiguravaju izravan uvid u tijek reakcije bez prekidanja procesa mljevenja, a koje je uveo PI sa suradnicima. Osim toga, za praćenje dinamike mljevenih krutina i specifičnih migracija atoma koristit ćemo izotopno obilježene krute tvari. Očekujemo da će rezultati projekta SystForSynt značajno unaprijediti razumijevanje mehanokemije i s vremenom omogućiti mehanokemiji da se pozicionira kao održivi pristup u sintezi s niskim otpadom te s učinkovitom uporabom resursa i energije. ]]></summary_hr><summary_en><![CDATA[Investigations into chemical transformations by mechanochemical milling is currently a fast growing field of chemistry and material science and the scope of such reactions is rapidly expanding. Conducting mechanochemical reactions in closed reaction vessels is however, limiting investigation into their course and consequently, their mechanisms are largely unknown. The SystForSynt project proposal is to address this very issue in the realm or organic transformations. We propose to conduct research in four work packages, that we recognise as highly significant, and which include verification of the Hammett correlation, understanding of liquid catalysis in liquid-assisted mechanochemical reactions, the transferability of mechanisms from milling to extrusion processing and the dynamics of atomic and molecular exchange between processed  particles and finally, organic rearrangement and radical reactions. To achieve this, the SystForSynt project will employ is situ monitoring techniques based on Raman spectroscopy and powder X-ray diffraction, which provide a direct insight into the reaction course without interrupting the milling process, and which we have pioneered. In addition, we will use isotope labelled solids to monitor the dynamics of milled solids and any specific atomic migrations. Results of the SystForSynt project are expected to significantly advance understanding of mechanochemistry, which will eventually allow mechanochemistry to position itself as a viable processing approach in a low-waste, atom- and energy-efficient synthesis in the future. ]]></summary_en></project><project>
<id>10251</id><title_hr><![CDATA[Hrvatsko prekršajno pravo u europskom kontekstu – izazovi i perspektive]]></title_hr><title_en><![CDATA[Croatian Misdemeanor Law in the European Context – Challenges and Perspectives]]></title_en><user_id>7173</user_id><user_firstLast_name>Marin Bonačić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2020-02</proposal_call><code>UIP-2020-02-6482</code><acronim><![CDATA[PrePraHR]]></acronim><duration>01.04.2021 - 31.03.2026</duration><status>U tijeku</status><financ_value>180.635,74 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Pravo, </scie_field_hr><scie_field_en>Law, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Pravni fakultet u Zagrebu]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Law]]></institution_en><team_members_id>6285, 26698, 4199, 1042, 26832, 3315, 24137, 26847, 6110, 6128, 5073, 7456, 19800, 865274, </team_members_id><team_members_names><![CDATA[Zoran  Burić, Ana Đanić Čeko, Marta Dragičević Prtenjača, Ivana Kanceljak, Hrvoje Filipović, Igor Martinović, Barbara Herceg Pakšić, Dunja Milotić, Marija Pleić, Ivan Vukušić, Sunčana Roksandić Vidlička, Ante Novokmet, Ivana Radić, Nikša Vojvoda Vojvoda, ]]></team_members_names><keywords_hr><![CDATA[prekršaji, prekršajni postupak, procesna jamstva, zaštita tržišnog natjecanja, prekršajnopravna zaštita]]></keywords_hr><keywords_en><![CDATA[misdemeanors, misdemeanor procedure, procedural safeguards, protection of competition, protection by misdemeanor law]]></keywords_en><summary_hr><![CDATA[Kroz hrvatski prekršajnopravni sustav godišnje prođe više od 130 tisuća okrivljenika zbog raznovrsnih prekršaja. Taj veliki broj predmeta ne prati odgovarajući znanstveni interes. Veći interes za prekršajno pravo javio se nakon presude Europskog suda za ljudska prava Maresti protiv Hrvatske kada je utvrđeno da je došlo do povrede načela ne bis in idem zbog vođenja prekršajnog i kaznenog postupka za isto ponašanje. S obzirom na mišljenje Europskog suda za ljudska prava da se u konkretnom prekršajnom postupku također radilo o  „optužbi za kazneno djelo“, postavlja se pitanje primjenjuju li se i u kojoj mjeri u prekršajnom postupku procesna jamstva kaznenog postupka, a što do sada nije bilo znanstveno razmatrano. To je osobito važno nakon donošenja niza direktiva Europske unije o procesnim jamstvima osumnjičenika i okrivljenika i pravima drugih osoba u kaznenom postupku. Glavni je cilj projekta utvrditi je li, i u kojoj mjeri, hrvatski prekršajni postupak usklađen sa standardima Europskog suda za ljudska prava i direktivama Europske unije. Uz to, u projektu će se razmatrati i niz drugih procesnih instituta, od kojih su mnogi nedavno uvedeni i također nisu još znanstveno obrađeni, kao i postupak za zaštitu tržišnog natjecanja u kojem se primjenjuje i Prekršajni zakon. U projektu će se istražiti i niz aktualnih materijalnopravnih pitanja općeg i posebnog dijela, s ciljem produbljivanja znanja o toj grani prava. Sva navedena pitanja istraživat će se ne samo pravnom analizom normi, nego i prikupljanjem informacija od praktičara te analizom sudske i upravne prakse. Važan rezultat ovog projekta bit će i zakonodavne preporuke te preporuke praktičarima koje će biti predstavljene znanstvenoj i stručnoj javnosti. Primjenjivost rezultata ovog projekta čini njegovu najveću vrijednost, a to je izgradnja kvalitetnijeg zakonodavnog okvira u skladu s europskim standardima kao i njihovo usvajanje u sudskoj i upravnoj praksi.]]></summary_hr><summary_en><![CDATA[In the Croatian misdemeanor system, more than 130,000 defendants per year are prosecuted for various offences. This large number of cases is not accompanied by an adequate scientific interest. A greater interest came after the Maresti v. Croatia judgment of the European Court of Human Rights when it was found that there was a violation of the principle of non bis in idem by conducting misdemeanor and criminal proceedings. Given the opinion of the ECtHR that the particular misdemeanor procedure also constituted the “criminal charge”, the question arises whether and to what extent procedural guarantees of criminal proceedings apply in misdemeanor proceedings. This is of particularly importance after the adoption of a series of EU directives on the procedural rights of the suspects and defendants and the rights of other persons in criminal proceedings. The main objective of the project is to determine whether and to what extent the Croatian misdemeanor procedure is in line with the standards of the ECtHR and EU directives. Additionally, a number of other procedural institutes will be explored in the project as well as a procedure for the protection of competition in which the Misdemeanor Act is being applied. The project will also explore a range of current issues of general and special part, with the aim of deepening knowledge about this area of law. All of these issues will be explored not only by legal analysis of the norms, but also by gathering information from practitioners and by analyzing judicial and administrative practice. An important result of this project will be legislative recommendations and recommendations to practitioners, which will be presented to the scientific and professional public. The applicability of the results of this project is its highest value, namely the building of better legislative framework in line with European standards as well as their adoption in judicial and administrative practice.]]></summary_en></project><project>
<id>10256</id><title_hr><![CDATA[Javno opravdanje i pluralizam sposobnosti]]></title_hr><title_en><![CDATA[Public justification and the pluralism of capabilities]]></title_en><user_id>1453</user_id><user_firstLast_name>Elvio Baccarini</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2020-02</proposal_call><code>IP-2020-02-8073</code><acronim><![CDATA[JOPS]]></acronim><duration>01.02.2021 - 31.01.2025</duration><status>Završio</status><financ_value>87.823,43 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filozofija, Interdisciplinarne humanističke znanosti, </scie_field_hr><scie_field_en>Philosophy, Interdisciplinary humanities, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Filozofski fakultet u Rijeci]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>4121, 3291, 22778, 865088, 19830, 867340, 868180, </team_members_id><team_members_names><![CDATA[Luca Malatesti, Nebojša Zelič, Ana Gavran Miloš, Iva Martinić, Ivan Cerovac, Shane Glackin, Katrien Schaubroeck, ]]></team_members_names><keywords_hr><![CDATA[evaulativni standardi, javno opravdanje, John Rawls, pluralizam, pristup temeljen na sposobnostima]]></keywords_hr><keywords_en><![CDATA[capability approach, evaluative standards, John Rawls, pluralism, public justification]]></keywords_en><summary_hr><![CDATA[Intencija je projekta, iz područja filozofije politike, razraditi teoriju opravdanja javnih evaluativnih standarda koja uvažava perspektive djelatnika u okolnostima pluralizma, uskladiti je s pristupom utemeljenim na sposobnostima, te primijeniti je na nekim relevantnim slučajevima. Evaluativni standardi su kriteriji kojima prosuđujemo moralna pravila, načela pravednosti, karakterne osobine te osobna i društvena stanja. 	Cilj projekta postižemo time što zadržavamo inspiraciju Johna Rawlsa i smatramo da javni evaluativni standardi nisu legitimni onda kada su opravdani razlozima koji vrijede za samo neke osobe. Ipak, za razliku od Rawlsa, rješenje ne vidimo u opravdanju koje referira isključivo na zajedničke razloge pojedinaca i na njihove moći racionalnosti i razložnosti. U fokus moralne pažnje dovodimo sve osobe i njihove perspektive, bez obzira na emocionalne i kognitivne raznolikosti. Navedeno postižemo zadržavanjem inspiracije Marthe Nussbaum, prema kojoj moralni status i pažnju treba usmjeriti i djelatnicima koji nisu racionalni i razložni, te im treba jamčiti ili podupirati za njih relevantne sposobnosti. Postižemo sponu između ovih dviju inspiracija tako što zadržavamo inspiraciju u Gausovoj teoriji javnog uma. Prema njemu javne evaluativne standarde trebamo opravdati snažnim poštivanjem pluralizma, uzimajući u obzir raznolikost posebnih perspektiva pojedinaca. Opravdanje postižemo kada imamo konvergenciju svih razloga koji su relevantni za različite pojedince. Pluralizam poštujemo i šire od Gausa. Gausov model zahtjeva isključenje onih djelatnika koji nemaju sposobnosti posjedovanja moralnih reaktivnih emocija. S druge strane, naš je cilj zahvatiti širi pluralizam koji je određen raznolikošću kognitivnih i emocionalnih ljudskih moći. 	Metodu javnoga opravdanja primjenjujemo na određenje relevantnih evaluativnih standarda i sposobnosti u područje psihijatrije, na primjerima iz spektra autizma i antisocijalnih poremećaja osobnosti.]]></summary_hr><summary_en><![CDATA[The intention of the project, within political philosophy, is to develop a theory of justification for public evaluative standards that respects the perspectives of all individuals in the context of pluralism, to align it with a capability approach, and to apply it in some relevant cases. Evaluative standards are the criteria by which we judge moral rules, principles of fairness, character traits, and personal and social conditions. We achieve the goal of the project by retaining the inspiration from John Rawls&#39;s thought that public evaluative standards are not legitimate if justified by reasons valid to only some individuals. Yet, unlike Rawls, we do not see a solution in justification that refers solely to individuals&#39; powers of rationality and reason. We bring moral attention to all persons and their perspectives, regardless of emotional and cognitive diversity. We achieve this by being by Martha Nussbaum, according to whom moral status and attention should also be given to individuals who are not rational and reasonable, with their relevant capabilities being guaranteed or supported. We establish a theoretical connection between these two models by retaining inspiration from Gaus who insists public evaluation standards should be justified by a strong adherence to pluralism, taking into account the diversity of specific perspectives of individuals. We achieve justification when we have a convergence of all reasons that are relevant to different individuals. We respect pluralism even more broadly than Gauss. The Gausian model requires the exclusion of those individuals who do not have the capacity to possess moral reactive emotions. Secondly, our goal is to embrace a broader pluralism that is determined by the diversity of cognitive and emotional human powers. We apply the public justification method to the determination of relevant evaluative standards and abilities within the field of psychiatry; in cases of autism spectrum and antisocial personality disorders.]]></summary_en></project><project>
<id>10258</id><title_hr><![CDATA[Usporedba reparacijskog odgovora koštanog tkiva upotrebom dentina, ksenogenog biomaterijala i autologne kosti]]></title_hr><title_en><![CDATA[Comparison of bone tissue repair response using dentin, xenogeneic biomaterial and autologous bone ]]></title_en><user_id>25715</user_id><user_firstLast_name>Olga Cvijanović Peloza</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2020-02</proposal_call><code>IP-2020-02-7875</code><acronim><![CDATA[MgXBiomBone]]></acronim><duration>22.02.2021 - 21.02.2025</duration><status>Završio</status><financ_value>143.128,28 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Dentalna medicina, Temeljne medicinske znanosti, Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Dental medicine, Basic Medical Sciences, Clinical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Medicine]]></institution_en><team_members_id>116, 4320, 29140, 25613, 24297, 26262, 12669, 26460, 3728, 29767, 26287, 865765, </team_members_id><team_members_names><![CDATA[Ivana Gobin, Davor Kuiš, Matko Oguić, Željka Perić Kačarević, Marija Pejakić, Ana Terezija Jerbić Radetić, Sanja Zoričić Cvek, Gabrijela Begić, Sonja Pezelj-Ribarić, Branko Trajkovski, Marko Blašković, Barbara Franovic, ]]></team_members_names><keywords_hr><![CDATA[alvolarna prezervacija, dentin, ksenogeni biomaterijal, koštana reparacija, d-PTFE membrane, bakterijski biofilm]]></keywords_hr><keywords_en><![CDATA[alvolar preservation, dentin, xenogeneic biomaterial, bone repair, d-PTFE membranes, bacterial biofilm]]></keywords_en><summary_hr><![CDATA[Alveolarnu prezervaciju moguće je postići s osteointegrativnim biomaterijalima te resorptivnim i neresorptivne membranama. Uz ksenogeni biomaterijal, u alveolarnoj prezervaciji se koristi i autologni dentin, zbog svog sličnog kemijskog sastava s koštanim tkivom i prisutnosti koštanih morfogenetskih proteina. Po završetku postupka alveolarne prezervacije očekujemo da će se vrijednosti obujma kosti razlikovati nakon primjene dentina u odnosu na Cerabone i Cerabone s autolognom kosti te da će biti povezane s većim intenzitetom osteoinduktivnog i protektivnog odgovora koštanog tkiva kao i s određenim MNGC staničnim fenotipom. Uz činjenicu da  prisustvo MNGC stanica ne mijenja kvalitetu kosti čak i 80 mjeseci nakon vađenja zuba, moguće je da ove stanice doprinose boljoj reparaciji koštanog tkiva. Kako bi se rasvijetlila uloga MNGC stanica potrebno je odrediti njihov fenotip (M1MNGC i M2MNGC)  i  broj u koštanom tkivu po završetku alveolarne prezervacije.  Cilj je provesti in vitro analizu kako bi se ispitalo sposobnost adherencije i stvaranja biofilma oralnih streptokoka i  parodontopatogena na Permamem i Cytoplast membrana, U kliničkom dijelu istraživanja očekujemo da bi potvrda bakterija u biofilmu  mogla utjecati na ishod postupka alveolarne prezervacije.  U eksperimentalnom modelu koštanog defekta, dobit će se vrijednosti 2D i 3D parametara kvalitete kosti te dinamika ekspresije upalnih i protektivnih citokina u pojedinim fazama koštanog cijeljenja. Očekujemo da će dinamika upalnog, protektivnog i osteoinduktivnog odgovora koštanog tkiva biti različita u pojedinim fazama cijeljenja i da će ovisiti o primjenjenom biomaterijalu. Pretpostavljamo da bi Cerabone s magnezijem mogao pokazati bolju razgradivost u odnosu na druge biomaterijale, što bi mu omogućilo skoru kliničku primjenu.]]></summary_hr><summary_en><![CDATA[Alveolar preservation can be achieved with osteointegrative biomaterials and resorptive and nonresorbable membranes. In addition to xenogeneic biomaterials, autologous dentin is used in alveolar preservation, because of its similar chemical composition to bone tissue and the presence of bone morphogenetic proteins. Upon completion of the alveolar preservation procedure, we expect that bone volume values will differ after dentin administration with Cerabone and Cerabone with autologous bone, and will be associated with a higher intensity of osteoinductive and protective bone tissue response as well as with a particular MNGC cell phenotype. In addition to the fact that the presence of MNGC cells does not alter bone quality even 80 months after tooth extraction, it is possible that these cells contribute to better bone tissue repair. In order to shed light on the role of MNGC cells, it is necessary to determine their phenotype (M1MNGC and M2MNGC) and the number in bone tissue upon completion of alveolar preservation. The aim is to perform an in vitro analysis to examine the ability of the adherence and biofilm production of oral streptococci and periodontopathogens to Permamem and Cytoplast membranes. In the experimental model of bone defect, the values of 2D and 3D bone quality parameters and the dynamics of expression of inflammatory and protective cytokines in individual stages of bone healing will be obtained. We expect that the dynamics of the inflammatory, protective, and osteoinductive responses of bone tissue will vary at different stages of healing and will depend on the biomaterial used. We hypothesize that Cerabone with magnesium could show better degradability than other biomaterials, which would allow it to be clinically used sooner.]]></summary_en></project><project>
<id>10260</id><title_hr><![CDATA[Utjecaj koštanog morfogenetskog proteina 3 (BMP3) na regeneraciju kosti]]></title_hr><title_en><![CDATA[Effect of bone morphogenetic protein 3 (BMP3) on bone regeneration]]></title_en><user_id>12659</user_id><user_firstLast_name>Igor Erjavec</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2020-02</proposal_call><code>IP-2020-02-5960</code><acronim><![CDATA[BON3gen]]></acronim><duration>25.09.2021 - 24.09.2025</duration><status>Završio</status><financ_value>106.178,25 eur</financ_value><scie_area_hr>Interdisciplinarno područje znanosti</scie_area_hr><scie_area_en>Interdisciplinary scientific area</scie_area_en><scie_field_hr>Biotehnologija u biomedicini, </scie_field_hr><scie_field_en>Biotechnology in Biomedicine, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>6237, 13183, 27063, 23905, </team_members_id><team_members_names><![CDATA[Vera Kufner, Tatjana Bordukalo Nikšić, Viktorija Rumenović, Petra Bonačić Bartolin, ]]></team_members_names><keywords_hr><![CDATA[osteogeneza, koštani morfogenteski protein 3, cijeljene prijeloma, osteoporoza, biomehanika kosti, FEM]]></keywords_hr><keywords_en><![CDATA[osteogenesis, bone morphogenetic protein 3, fracture healing, osteoporosis, bone biomechanics, FEM]]></keywords_en><summary_hr><![CDATA[Koštani morfogenetski proteini (BMP, eng. Bone Morphogenetic Proteins) su porodica proteina unutar obitelji proteina transformirajućeg čimbenika rasta beta i uključeni su u gotovo sve procese rasta i razvoja organizama. BMP3 je pronađen u demineraliziranom koštanom matriksu gdje čini oko 65% ukupne količine svih BMP-a. U različitim in vitro i in vivo esejima pokazano je da BMP3 nema osteogenu aktivnost, za razliku od ostalih članova BMP porodice te da u kombinaciji sa BMP-ima inhibira njihovu aktivnost dok je u miševa sa izbačenim genom za BMP3 koštana masa povećana. U projektu će se koristiti miševi sa izbačenim genom za BMP3. U in vitro dijelu projekta će se analizirati matične stanice koštane srži gdje će se diferencirati u osteoblaste i osteoklaste kako bi se vidio utjecaj BMP3 gena na sazrijevanje i proliferaciju stanica. U in vivo dijelu projekta će se koristiti mišji modeli u kojima će se promatrati utjecaj gena za BMP3 na regeneraciju koštanog tkiva. Modeli koji će se koristiti su: 1) stvaranje ektopične kosti; 2) prijelom tibije; 3) osteoporoza. Utjecaj BMP3 na regeneracija koštanog tkiva će se promatrati putem RNA-Seq, histološki, imunohistokemijski, sortiranja stanica i mikro CT-a, te će se u sklopu projekta uspostaviti suradnja sa Fakultetom strojarstva i brodogradnje u Zagrebu (FSB), kako bi se razvio računalni model analize biomehaničke snage kosti koristeći metodu konačnih elemenata (Finite Elements Method, FEM). FEM će se izvoditi na podacima dobivenim mikro CT-om, te ona predstavlja nadogradnju u analizi koštanog tkiva. Pomoću RNA-Seq metode će se detektirati promjene u genskoj ekspresiji u svakom od mišjih modela kako bi izdvojili gene uključene u regeneraciju kosti.  Ciljevi projekta će biti otkriti utjecaj BMP3 na regeneraciju kosti, uspostaviti suradnju sa FSB-om i uvesti novu metodu analize kosti te poboljšati znanja i uvjete prilikom izvođenja pokusa korištenih u istraživanju koštanog tkiva]]></summary_hr><summary_en><![CDATA[Bone morphogenetic proteins (BMP) are a sub-family of proteins in a large transforming growth factor beta (TGF-ß) family of proteins. They are fundamentally involved in all the process of organism growth and development. BMP3 was originally found as a constituent of demineralized bone matrix where it makes more than 65% of all BMPs combined. Unlike all other members of BMP protein family, no osteogenic activity of BMP3 was found in various in vitro and in vivo assays. When combined with other BMPs, BMP3 inhibited their activity, while the lack of BMP3 in knock out (KO) mice resulted in increased bone mass. In this project mice with knocked out gene for BMP3 will be used. Bone marrow stem cells (BMSC) from KO and wild type (WT) mice will be analyzed and differentiated into osteoblastic and osteoclastic cells to test the lack of BMP3 on cell differentiation, maturation and proliferation. Mice models in vivo that will be used in this project to test bone formation and regeneration are : 1) ectopic bone formation; 2) tibial fracture repair; 3) osteoporosis. Effect of BMP3 on bone tissue regeneration will be examined through RNA-Seq, histology, immunohistochemistry, flow cytometry and micro CT. Collaboration with the Faculty of Mechanical Engineering and Naval Architecture (FSB) based on micro CT scans in development of computer based biomechanical properties calculations by using finite elements method (FEM) will be established. Aim of this collaboration is to further augment micro CT data in bone tissue analysis. By using RNA-Seq key genes involved in bone regeneration and repair will be isolated in each of the mouse models and further studied.  The project aims are: revealing the effect of BMP3 on bone regeneration, establishing collaboration with FSB to introduce new method of bone analysis, and to improve competitiveness by promoting new knowledge and methods used in bone analysis.]]></summary_en></project><project>
<id>10263</id><title_hr><![CDATA[Istraživanje emocija u (re)konstrukciji identiteta dijaspore: Hrvati u Australiji i Novom Zelandu (1945.-1991.)]]></title_hr><title_en><![CDATA[Exploring emotions in the (re)construction of diaspora identity: Croats in Australia and New Zealand (1945-1991)]]></title_en><user_id>4957</user_id><user_firstLast_name>Ivan Hrstić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2020-02</proposal_call><code>UIP-2020-02-1283</code><acronim><![CDATA[CROCEANIA]]></acronim><duration>01.03.2021 - 28.02.2026</duration><status>U tijeku</status><financ_value>134.846,37 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Povijest, Interdisciplinarne humanističke znanosti, </scie_field_hr><scie_field_en>History, Interdisciplinary humanities, </scie_field_en><institution_hr><![CDATA[Institut društvenih znanosti Ivo Pilar]]></institution_hr><institution_en><![CDATA[Institute of Social Sciences Ivo Pilar in Zagreb]]></institution_en><team_members_id>6603, 1357, 22797, 20100, 855299, 865635, 25511, </team_members_id><team_members_names><![CDATA[Marica Marinović Golubić, Josip Mihaljević, Stipica Grgić, Dino Vukušić, Nenad  Bukvić , Matko Krce-Ivančić, Andrej Nuredinovic, ]]></team_members_names><keywords_hr><![CDATA[emocije, dijaspora, migracije, dokolica, identitet]]></keywords_hr><keywords_en><![CDATA[emotions, diaspora, migrations, leisure, identity]]></keywords_en><summary_hr><![CDATA[Svrha projekta je istražiti ulogu emocija u razvoju transnacionalnih migrantskih zajednica kroz analizu povijesti hrvatskog iseljeništva u Australiji i Novom Zelandu u razdoblju od 1945. do 1991. Osnovni teorijski i metodološki okvir istraživanja postavljen je u konceptu povijesti emocija. Ovaj tip istraživanja osigurat će širu i dublju spoznaju fenomena migracija, kao jednog od ključnih aspekata općeg procesa modernizacije. Ponudit će reinterpretaciju postojećih istraživanja o hrvatskom iseljeništvu koja se uglavnom baziraju na ekonomskoj i ideološkoj racionalizaciji migracija, primordijalističkom pripisivanju identiteta iseljenika na temelju njihovog etničkog podrijetla te fokusu na političke aktivnosti u okviru dijaspore u užem smislu riječi. Iseljenicima će se u sklopu istraživanja pristupiti kao akterima u ekonomskim, kulturnim i političkim procesima kako u zemlji iseljenja, tako i u zemljama useljenja, a oblikovanju dijaspora kao pitanju društvene mobilizacije. Prema osnovnoj tezi, iseljenici s područja Hrvatske su u istraživanom razdoblju u obje države formirali po dvije dijaspore, hrvatsku i jugoslavensku. Ključni aspekt njihova procesa formacije odvijao se u prostoru dokolice. Identitetu iseljenika pristupit će se u ovom projektu kao socijalnom konstruktu, iz teorijske perpektive povijesti emocija. S obzirom na cilj i svrhu projekta, u istraživanju ćemo se fokusirati na istraživanje sekundarnih emocija, kao kulturalno oblikovanih fenomena. Dijasporama će se u okviru projekta pristupiti u smislu &#39;&#39;emocionalnih zajednica&#39;&#39;, a istraživanje će se temeljiti na analizi arhivske građe, periodike i intervjuima s iseljenicima.]]></summary_hr><summary_en><![CDATA[The scientific purpose of the project is to explore the role of emotions in the development of transnational migrant communities through the analysis of the history of Croatian communities in Australia and New Zealand from 1945 to 1991. The basic theoretical and methodological framework of the research is set within the concept of the history of emotions. The research will provide deeper understanding of the phenomenon of migrations, as one of the key aspects of the modernization process. It will offer a reinterpretation of existing research on Croatian diaspora, which are based on the economic and ideological rationalizations of migrations, attributing thereby migrants’ identities only on the basis of their ethnic origin; and usually placing the focus on political activities within the diaspora in the narrow sense of the term. Migrants will be within this project approached as actors in economic, cultural and political processes, both in the country of emigration and in the receiving countries, while the diasporas will be approached as a process of social mobilization. According to the main thesis, emigrants from the territory of Croatia formed two diasporas in both countries in the studied period, the Croatian and the Yugoslav. A key aspect of their formation process took place in the space known as leisure. Migrants’ identities will be approached in this project as a social construct, from a theoretical perspective of the history of emotions. The research will focus on the exploration of secondary emotions, as culturally conditioned phenomena. Diasporas will be within the project approached as &#39;&#39;emotional communities&#39;&#39;, while the research will be based on archival research, press analysis and the conduction of interviews with migrants.]]></summary_en></project><project>
<id>10271</id><title_hr><![CDATA[Nagle klimatske promjene – Dokazi iz kvartarnih sedimentoloških zapisa u Hrvatskoj]]></title_hr><title_en><![CDATA[Abrupt climate changes – Evidence from Quaternary sedimentological sequences in Croatia]]></title_en><user_id>3320</user_id><user_firstLast_name>Lidija Galović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2020-02</proposal_call><code>IP-2020-02-3274</code><acronim><![CDATA[ACCENT]]></acronim><duration>01.04.2021 - 31.08.2025</duration><status>Završio</status><financ_value>119.687,57 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Geologija, Interdisciplinarne prirodne znanosti, </scie_field_hr><scie_field_en>Geology, Interdisciplinary natural sciences, </scie_field_en><institution_hr><![CDATA[Hrvatski geološki institut]]></institution_hr><institution_en><![CDATA[Croatian Geological Survey]]></institution_en><team_members_id>19966, 29116, 29323, 12776, 20279, 7107, 20272, 3030, 19512, </team_members_id><team_members_names><![CDATA[Ajka Šorša, Rosa Maria Poch, Koen Beerten, Stjepan Husnjak, Rodoljub Gajić, Petar Stejic, Mihajlo Pandurov, Stanko Ružičić, Jasmina Martinčević Lazar, ]]></team_members_names><keywords_hr><![CDATA[Nagle klimatske promjene, Kvartar, prapor, Đurđevački pijesci, fluvioglacijalnim sedimenti, Vrgoračko jezero, Hrvatska]]></keywords_hr><keywords_en><![CDATA[Abrupt climate changes, Quaternary, loess, The Đurđevac Sands, fluvioglacial sediments, The Vrgorac Lake, Croatia]]></keywords_en><summary_hr><![CDATA[Istraživanje kvartarnih sedimenata (HRZZ projekt SAPIQ) rezultiralo je značajnim otkrićima u prapor-paleotlo sekvencijama i u Đurđevačkim pijescima u panonskom području (kontinentalna klima) te u fluvioglacijalnim sedimentima u podnožju Velebita i u Vrgoračkom jezeru u dinarskom području (mediteranska klima).U prapor-paleotlo sekvencijama otkriveno je 16 kumuličnih horizonata razvijenih u krovini dobro razvijenih paleotala. Oni predstavljaju paleoklimatske zapise dinamike i razvoja 16 klimatskih promjena. Predloženo istraživanje bit će usredotočeno na analizu kumuličnih horizonata u SI Hrvatskoj, dajući detaljan opis prijelaza iz toplog u glacijalno razdoblje tijekom gornjeg pleistocena. Osim toga, istraživanje paleotala i geomorfološko/sedimentoloških obilježja Đurđevačkih pijesaka može pomoći u utvrđivanju prirode prijelaza pleistocen-holocen na ovom području, kao i potencijalnih paleoekoloških promjena izazvanih holocenskim klimatskim promjena. Ti terestički zapisi na jugu Karpatskog bazena pružit će uvid u intenzitet, trajanje i prostornu varijabilnost klimatskih promjena. Na temelju dobivenih rezultata bit će korelirani sedimentološki zapisi klimatskih promjena tijekom gornjeg pleistocena i holocena u kontinentalnom dijelu Hrvatske (kontinentalna klima) s onima u dinarskom (jadranskom) dijelu Hrvatske (mediteranska klima) (lokacije udaljene samo 300 km), dajući uvid kako su se klimatske promjene manifestirale na udaljenim eolskim-fluvioglacijalnim-jezerskim facijesima JI Europe. Dobiveni podaci čine osnovu za kontinentalnu korelaciju s Europskim pojasom pijeska (SZ Europe) i s Jadranskim morem. Rezultati ovog projekta omogućit će predviđanje dinamike transformacija povezanih s trendovima klimatskih promjena u tim klimatskim regijama i primjene održivog upravljanja zemljištem, posebno u pogledu geo-hazarda poput klizišta, odrona, debritnih tokova, poplava i premještanja dina.]]></summary_hr><summary_en><![CDATA[The exploration of Quaternary sediments (HRZZ project SAPIQ) has resulted in significant findings in loess-palaeosoil sequences and the Đurđevac Sands in the Pannonian area (continental climate) and fluvioglacial sediments in the foothills of the Velebit Mt. and in the Vrgorac Lake in the Dinaric area (mediterranean climate).Explorations of loess-palaeosoil sequences revealed the existence of the 16 cumulic horizons, which evolved just above well-developed palaeosoils. They represent paleoclimate archives of dynamics of the 16 climate changes. The proposed research will be focused on analysing cumulic horizons in NE Croatia, providing detailed descriptions of transitions from the warm to the glacial period in the Upper Pleistocene. In addition, the investigation of palaeosoils and geomorphological/sedimentological features in the dunes of the Đurđevac Sands may help to determine the nature of the Pleistocene-Holocene transition in this area, as well as potential Holocene climate-related palaeoenvironmental changes. These terrestrial archives in the S Carpathian Basin will provide insight into the magnitude, timing and spatial variability of climate changes. Results will represent milestones for correlation of the Upper Pleistocene and Holocene sedimentological archives of climate changes in the continental part of Croatia with those in the Dinaric (Adriatic) part of Croatia (locations only 300 km away). This will yield insight into aeolian-fluvioglacial-lacustrine teleconnections in SE Europe. The obtained data form the basis for supraregional correlations with the European Sand Belt (NW Europe) and the Adriatic Sea. The outcomes of this project will allow predicting the dynamics of the transformations related to trends of climate changes in these climatic regions and application by sustainable land-use managment, especially concerning geohazards like landslides, slumps, debris flows, floods and drifting dunes.]]></summary_en></project><project>
<id>10275</id><title_hr><![CDATA[S(c)lavoni(j)a: ime, opseg i granični položaj u srednjem i ranom novom vijeku]]></title_hr><title_en><![CDATA[S(c)lavoni(j)a: name, scope and frontier position in the Middle Ages and early modern time]]></title_en><user_id>1311</user_id><user_firstLast_name>Robert Skenderović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2020-02</proposal_call><code>IP-2020-02-3333</code><acronim><![CDATA[SLAVNSCOF]]></acronim><duration>15.03.2021 - 14.03.2025</duration><status>Završio</status><financ_value>76.381,98 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Povijest, Filologija, Etnologija i antropologija, </scie_field_hr><scie_field_en>History, Philology, Ethnology and anthropology, </scie_field_en><institution_hr><![CDATA[Hrvatski institut za povijest]]></institution_hr><institution_en><![CDATA[Croatian Institute of History]]></institution_en><team_members_id>28952, 7174, 783, 29694, 1164, </team_members_id><team_members_names><![CDATA[Hrvoje Kekez, Anđelko Vlašić, Stanko Andrić, Ante Grubišić, Milan Vrbanus, ]]></team_members_names><keywords_hr><![CDATA[Slavonija, pograničje, srednji vijek, Early Modern History, name ]]></keywords_hr><keywords_en><![CDATA[Slavonia, frontline, Middle Ages, Early Modern History, scope]]></keywords_en><summary_hr><![CDATA[U dosadašnjoj je hrvatskoj historiografiji napisano mnogo radova o povijesti Slavonije u srednjem i ranome novom vijeku, ali još uvijek nije napravljeno cjelovito istraživanje njenog imena i opsega u to doba. Dobro je poznata, iako još uvijek ne i sustavno istražena, činjenica da je u srednjem vijeku geografsko ime S(c)lavonia bilo obilježeno homonimijom i polivalentnošću te da su se njime u različitim razdobljima označavala različita područja na širokom prostoru od Baltika do Balkanskog poluotoka. S takvom uporabom termina koji u osnovi znači &#39;slavenska zemlja&#39; u zapadnim/latinskim izvorima donekle je usporediva upotreba termina sklavinia (????ß????) u bizantskoj kulturnoj sferi, gdje je navedena riječ u ranom srednjem vijeku funkcionirala kao opća imenica i politički tehnički termin. U tom širem kontekstu, posebno je zanimljivo pitanje specijalizacije imena Slavonia u okviru Ugarsko-Hrvatskog Kraljevstva, gdje se u 13. stoljeću oblikovala upravna cjelina poznata kao Kraljevina Slavonija (Regnum Slavoniae), s određenom mjerom političke i kulturne zasebnosti. Pitanje imena i opsega potonje pokrajine naročito je zanimljivo i važno zbog opće poznate činjenice da je političko-geografski pojam Slavonije doživio pomicanje u ranome novom vijeku od zapada prema istoku, odnosno da se prostor srednjovjekovne Slavonije ne poklapa s prostorom današnje Slavonije. To ima brojne implikacije koje utječu na razumijevanje državnosti i državnih granica Hrvatske i Ugarske, zatim na razumijevanje političkih koncepata koji su promicani iz raznih političkih centara moći, a na kraju i razumijevanje oblikovanja institucija središnje vlasti – Hrvatskog sabora, Slavonskog sabora, zajedničkog Hrvatsko-slavonsko-dalmatinskog sabora, hrvatskih i slavonskih županija te mnogih kratkotrajnih institucija - Zemaljske uprave za Slavoniju, Hrvatskog kraljevinskog vijeća i drugih.]]></summary_hr><summary_en><![CDATA[In  Croatian historiography numerous works have been written on the history of Slavonia in the Middle Ages and the Early Modern Period; however no complete research into its name and extent at the time has yet been conducted. It is a well known fact, although still not systematically explored, that the geographical name S(c)lavonia was marked by homonymy and polyvalence and that at various times various areas of the broad territory form the Baltic to the Balkan Peninsula carried this name. Such a use of the term, which, in essence, means ‘Slavic land’, can in western/Latin sources to a certain extent be compared with the usage of the term Sklavinia (????ß????) in the Byzantine cultural sphere where during the Early Middle Ages this word functioned as a common noun and a political technical term. Particularly interesting, in a broader context, is the issue of the special use of the name Slavonia within the Hungarian-Croatian Kingdom, where in the 13th century the administrative unit, known as the Kingdom of Slavonia, was shaped with a certain degree of political and cultural separateness. The issue of the name and extent of the province is particularly interesting and significant due to the generally known fact that the political-geographical term Slavonia experienced a shift during the Early Modern Ages from west to east, i.e. the area of medieval Slavonia is not equivalent to the area of Slavonia today. This has led to numerous implications that impact on the understanding of statehood and state borders between Croatia and Hungary, further the understanding of political concepts promoted by various political centres of power and eventually the understanding of the shaping of institutions of the central government such as the Croatian Parliament, the Slavonian Parliament, the common Croatian-Slavonian-Dalmatian Parliament, the Croatian and Slavonian counties as well as numerous short-lived institutions .]]></summary_en></project><project>
<id>10284</id><title_hr><![CDATA[Uloga ličnosti, motivacije i socio-emocionalnih kompetencija u profesionalnoj dobrobiti učitelja u ranoj fazi karijere]]></title_hr><title_en><![CDATA[The role of personality, motivation and socio-emotional competences in early-career teachers&#39; occupational well-being]]></title_en><user_id>7765</user_id><user_firstLast_name>Iris Marušić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2020-02</proposal_call><code>IP-2020-02-6039</code><acronim><![CDATA[TeachWell]]></acronim><duration>01.02.2021 - 31.01.2025</duration><status>Završio</status><financ_value>52.167,23 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Psihologija, Interdisciplinarne društvene znanosti, </scie_field_hr><scie_field_en>Psychology, Interdisciplinary social sciences, </scie_field_en><institution_hr><![CDATA[Institut za društvena istraživanja]]></institution_hr><institution_en><![CDATA[Institute for Social Research in Zagreb]]></institution_en><team_members_id>21265, 11293, 13404, 12645, 21221, 25891, 865026, 866583, </team_members_id><team_members_names><![CDATA[Ivana Jugović, Tea Pavin Ivanec, Josipa Mihić, Jelena Matić Bojić, Josip Šabić, Mirta Mornar, Dora Petrović, Paula Pedić Duić, ]]></team_members_names><keywords_hr><![CDATA[ličnost, motivacija za poučavanje, socio-emocionalne kompetencije, profesionalna dobrobit, učitelji]]></keywords_hr><keywords_en><![CDATA[personality, motivation for teaching, socio-emotional competences, occupational well-being, teachers]]></keywords_en><summary_hr><![CDATA[Cilj ovog istraživanja je ponuditi cjelovito mapiranje afektivno-motivacijskih obilježja učitelja, koja čine važan, ali nedovoljno istražen aspekt učiteljskih kompetencija, te ispitati ulogu tih obilježja u profesionalnoj dobrobiti učitelja u ranoj fazi karijere. Novija istraživanja naglašavaju ulogu ličnosti, motivacije za poučavanje i socio-emocionalnih kompetencija u nizu poželjnih ishoda kod učitelja kao što su entuzijazam za poučavanje, zadovoljstvo i angažman na poslu, namjera ostanka u profesiji i niska razina sagorijevanja, koje smo u našoj konceptualizaciji objedinili terminom profesionalna dobrobit učitelja. Predložena su sljedeća istraživačka pitanja: 1. Kakav je izravan i neizravan doprinos ličnosti, motivacije za poučavanje i socio-emocionalnih kompetencija u predviđanju profesionalne dobrobiti učitelja? 2. Kakav je odnos između dobrobiti učitelja i učeničke percepcije motivacijskih elemenata kvalitete poučavanja? 3. Kako učitelji doživljavaju svoju profesionalnu dobrobit? Koristit će se istraživački nacrt mješovitog tipa koji kombinira kvantitativne i kvalitativne metode. Otprilike 800 predmetnih učitelja osnovnih škola s do 5 godina iskustva u nastavi ispunit će upitnike ličnosti, motivacije, socio-emocionalnih kompetencija i profesionalne dobrobiti, 120 njih će procijeniti i njihovi učenici, a 60 će ih sudjelovati u intervjuima. Očekuje se da će istraživanje ponuditi konceptualni okvir koji može usmjeriti buduća istraživanja u ovom području. Pristup mješovitih metoda koji integrira perspektive učitelja i učenika doprinijet će novim metodološkim smjernicama za istraživanja učiteljske profesije. Preporuke koje proizlaze iz studije pomoći će u osmišljavanju mjera obrazovne politike za potporu profesionalnoj dobrobiti učitelja u ranoj fazi karijere i njihovom ostanku u profesiji. To je posebno važno za hrvatski obrazovni kontekst koji se sve više suočava s problemima zapošljavanja i zadržavanja učitelja.]]></summary_hr><summary_en><![CDATA[The aim of this study is to offer an extensive mapping of affective-motivational teacher characteristics that form an important, but underresearched aspect of teacher competences, and to explore the role of these characteristics in early-career teachers’ occupational well-being. Recent studies underline the role of personality, motivation to teach and socio-emotional competences in teacher outcomes such as enthusiasm for teaching, job satisfaction, work engagement, plans to remain in the profession and low burnout. These outcomes together form the occupational well-being of early-career teachers and are the focus of this research. The following research questions are proposed: 1. What are direct and indirect contributions of teachers’ personality, motivation for teaching and socio-emotional competences in prediction of their occupational well-being? 2. What is the relationship between teachers’ occupational well-being and students’ perceptions of motivational elements of instructional quality? 3. How do teachers perceive their occupational well-being? A mixed methods research design combining quantitative and qualitative methods will be used. About 800 elementary-school subject teachers with up to 5 years of experience will provide self-ratings of personality, motivation, socio-emotional competences and teacher occupational well-being, 120 of them will be rated by their students, while 60 of them will take part in interviews. The project will offer a conceptual framework that can streamline the future research in this area. Mixed methods approach that integrates both student and teacher views contributes to the new methodological perspectives in the research of teacher profession. Recommendations from the study will assist in designing policy measures to support the occupational well-being and retention of early-career teachers. This is of particular importance for the Croatian context that is increasingly facing the problems of teacher recruitment and retention.  ]]></summary_en></project><project>
<id>10287</id><title_hr><![CDATA[Duboka mozgovna stimulacija u bolesnika s poremećajem svijesti: potencijalni prediktivni čimbenici i strukturalne promjene mozga]]></title_hr><title_en><![CDATA[Deep brain stimulation in patients with disorders of consciousness: potential predictive factors and structural brain changes]]></title_en><user_id>7303</user_id><user_firstLast_name>Darko Chudy</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2020-02</proposal_call><code>IP-2020-02-4308</code><acronim><![CDATA[DBS]]></acronim><duration>01.04.2021 - 31.03.2025</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Kliničke medicinske znanosti, Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Clinical sciences, Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Klinička bolnica "Dubrava", Zagreb]]></institution_hr><institution_en><![CDATA[Dubrava Clinical Hospital, Zagreb]]></institution_en><team_members_id>19937, 7611, 7311, 27004, 27183, 12824, 27177, 26994, 27021, 25408, 867697, 867704, </team_members_id><team_members_names><![CDATA[Ana Hrkać Pustahija, Domagoj Dlaka, Dominik Romić, Petar Marčinković, Darko Orešković, Marina  Raguž, Anđelo  Kaštelančić , Nina Predrijevac, Veronika Paradžik, Gabriela Plosnić, Filip Đerke, Maja Majdak, ]]></team_members_names><keywords_hr><![CDATA[duboka mozgivna stimulacija, poremećaji svijesti, magnetska rezonancija, evocirani potencijali, volumetrija]]></keywords_hr><keywords_en><![CDATA[deep brain stimulation, disorders of consciousness, magnetic resonance imaging, evoked potentials, volumetry]]></keywords_en><summary_hr><![CDATA[Duboka mozgovna stimulacija (DMS) je postupak kojim se uvodi elektroda u subkortikalne strukture središnjeg živčanog sustava te se preko njih električno stimulira središnji  živčani sustav. DMS kod bolesnika s poremećajima pokreta (Parkinsonova bolest, distonija) ublažava simptome bolesti i poboljšava kvalitetu života. Prikazan je povoljan učinak DMS kod bolesnika s tremorom, Gill de la Tourettovim sindromom, psihijatrijskim poremećajima i sl. Naša istraživačka skupina pokušava dokazati opravdanost uporabe DMS u liječenju bolesnika s poremećajima svijesti. Za njih ne postoji standardiziran tretman, a zahtijevaju posebnu skrb i uključenost skrbnika i društva. Nema zadovoljavajućeg objašnjenja kako DMS dovodi do promjena unutar neuronske mreže i smanjenja simptoma bolesti. Brojna pitanja su neriješena; dolazi li uslijed stimulacije dubokih mozgovnih jezgara do strukturne promjene mozga? Koji klinički, neurofiziološki i neuroradiološki znaci ukazuju na poboljšanje bolesnika s poremećajem svijesti?, može li se kvantificirati reorganizacija struktura te kakve su kognitivne funkcije nakon poboljšanja bolesnika s poremećajem svijesti? Hipoteza je da DMS inducira strukturne promjene moždanih jezgara i aksonalnih snopova kod bolesnika s poremećajima svijesti. Oblikovali smo specifične ciljeve kako bi pokušali pronaći odgovore na ova pitanja primjenom magnetske rezonancije, kliničkim, neurofiziološkim te psihološkim  procjenama. Rezultati će predložiti poboljšane kriterije odabira bolesnika s poremećajima svijesti za ugradnju DMS, bolje razumijevanje djelovanja DMS, pružiti podatke o strukturnim promjenama mozga te omogućiti dobre polazne osnove za daljnja istraživanja. Zavod za neurokirurgiju KB Dubrava, Referentni Centar za funkcijsku i stereotaktičku za neurokirurgiju Ministarstva zdravstva je jedina ustanova u RH koja može koristiti DMS u liječenju neuroloških bolesnika te jedna od nekoliko institucija u svijetu koja se bavi uporabom DMS u liječenju poremećaja svijesti.]]></summary_hr><summary_en><![CDATA[Deep brain stimulation (DBS) is a procedure by which an electrode is introduced into the subcortical structures and electrically stimulated through the central nervous system. DBS in patients with movement disorders (Parkinson&#39;s disease, dystonia) relieves disease symptoms and improves quality of life. The beneficial effect of DBS in patients with tremor, Gill de la Tourette syndrome, psychiatric disorders, etc. was shown. Our research team is attempting to prove the use of DBS in the treatment of patients with disorders of consciousness (DOC). There is no standardized treatment for such patients; they require special care, involvement of the parents of the society as a whole. To date, there is no satisfactory explanation of how DBS leads to changes within the neural network and causes the reduction of symptoms of neurological diseases. A number of issues are unresolved; is there a structural change in the brain due to stimulation of the deep brain nuclei? What clinical, neurophysiological, and neuroradiological signs indicate improvement in patients with a DOC? The hypothesis is that DBS induces structural changes in brain nuclei and axonal bundles in patients with DOC. We have formulated specific goals to try to find answers to these questions using magnetic resonance imaging, clinical, neurophysiological and psychological assessments. The results of the project will propose improved criteria for the selection of patients with DOC for the implantation of DMS, a better understanding of the functioning of DBS, to provide information on structural brain changes, and to provide a good starting point for further research. Department of Neurosurgery UH Dubrava, Reference Center for Functional and Stereotactic for Neurosurgery, Ministry of Health is the only institution in the Republic of Croatia that can use DBS in the treatment of neurological patients and one of several institutions in the world that deals with the use of DBS in the treatment of DOC.]]></summary_en></project><project>
<id>10295</id><title_hr><![CDATA[Podizanje zrelosti visokih učilišta za implementaciju analitika učenja]]></title_hr><title_en><![CDATA[Improving HEI maturity to implement learning analytics]]></title_en><user_id>12509</user_id><user_firstLast_name>Nina Begičević Ređep</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2020-02</proposal_call><code>IP-2020-02-5071</code><acronim><![CDATA[HELA]]></acronim><duration>01.03.2021 - 28.02.2025</duration><status>Završio</status><financ_value>103.023,43 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Informacijske znanosti, Interdisciplinarne društvene znanosti, </scie_field_hr><scie_field_en>Information sciences, Interdisciplinary social sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet organizacije i informatike]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Organization and Informatics]]></institution_en><team_members_id>13328, 855310, 12521, 12523, 13731, 1287, 6191, 27045, 13776, 29560, 29420, 27317, 26859, 27084, 865000, 12583, 1388, 866666, 866721, 867828, </team_members_id><team_members_names><![CDATA[Igor Balaban, Darko Grabar Grabar, Nikola Kadoić, Katarina Pažur Aničić, Sandra Kučina Softić, Marina Klačmer Čalopa, Jelena Gusić, Petra Vondra, Diana Šimić, Barbara Šlibar, Bart Rienties, Hendrik Drachsler, Van Petegem Wim, Ivana Đunđek Kokotec, Sabina Rako, Valentina Đurek, Sandra Lovrenčić, Ivana Dvorski Lacković, Ivan Kekez, Tena Jagacic, ]]></team_members_names><keywords_hr><![CDATA[analitike učenja, visoko obrazovanje, hibridno učenje, rudarenje podataka, model zrelosti]]></keywords_hr><keywords_en><![CDATA[learning analytics, higher education, blended learning, data mining, maturity model ]]></keywords_en><summary_hr><![CDATA[Temeljna svrha ovog projekta je doprinijeti boljem razumijevanju i optimizaciji procesa učenja i poučavanja podržanog analitikama učenja. način na koji to planiramo postići je kroz unapređenje zrelosti visokih učilišta u primjeni analitika učenja. Budući da hibridno okruženje učenja postaje sveprisutno i uzimajući u obzir da taj kontekst može presudno utjecati na usvajanje LA-a, mi ćemo suziti opseg našeg istraživanja na hibridno okruženje za učenje. Predlažemo razviti okvir zrelosti za implementaciju analitika učenja u hibridnom okruženju učenja.Projekt uključuje 5 znanstvenih ciljeva:Cilj 1:Identificirati slučajeve korištenja i nedostatke u korištenju analitika učenja u hibridnom okruženju na razini institucijskih strategija, studijskih programa, predmeta i predavanjaCilj 2:Identificirati resurse potrebne za implementaciju analitika učenja u hibridnom okruženju na razini institucijskih strategija, studijskih programa i predmetaCilj 3:Identificirati pedagoške, etičke i probleme privatnosti kod upotrebe analitika učenja i kako mogu biti riješeniCilj 4: Razviti model zrelosti za implementaciju analitika učenja u hibridnom okruženjuCilj 5: Razviti slučajeve korištenja analitika učenjaU istraživanju će se koristiti kvantitativne i kvalitativne istraživačke metode. Glavni rezultati projekta su R1.1 Konceptna mapa LA, R1.2 Deskriptori metapodataka za slučajeve korištenja LA, R1.3 Revizija slučajeva korištenja LA, R2.1 Revizija resursa za implementaciju LA, R3.1 Vodič za etičko i pedagoško uvođenje LA poštujući privatnost i zaštitu osobnih podataka, R4.1 Okvir zrelosti za korištenje LA u hibridnom okruženju (LAAMF), R4.2 Set instrumenata za operacionalizaciju zrelosti korištenja LA, R5.1 Model infrastrukture za provedbu LA-a u hibridnom obrazovnom okruženju, R5.2 Razvijeni LA modeli s pratećim opisima upotrebe korištenjem deskriptora metapodataka definiranih u cilju 1.]]></summary_hr><summary_en><![CDATA[The purpose of this research is to contribute to a better understanding and optimization of the teaching and learning processes supported by LA. The way we plan to achieve it is through improving HEI maturity to implement LA. Since blended learning environments are becoming ubiquitous, and taking into account that context may have decisive influence on LA adoption, we will narrow the scope of our research to the blended learning environments. We propose to develop a maturity framework for LA implementation in a blended learning environment. There are five scientific objectives in the project: Objective 1: Identify use cases and gaps in use of LA in a blended educational environment in HE at the level of institutional policy, study programs, courses and lectures.Objective 2: Identify resources necessary to implement LA in a blended educational environment at levels of institution policy, study program and course.Objective 3: Identify pedagogical, ethical and privacy issues in use of LA and how they can be resolved.Objective 4: Develop LA adoption maturity framework (LAAMF) in blended educational environment.Objective 5: Develop model use cases of LA.We will combine quantitative and qualitative research methodology. The main results of this proposal are: D1.1 Concept map of LA research and application landscape, D1.2 Conceptual model of LA use case with metadata descriptors, D1.3 Review of LA use cases, D2.1 Review of resources for implementation of LA, D3.1 Guidelines for ethical and pedagogically sound LA respecting privacy and personal dana, 5.1 Model infrastructure for implementation of LA in a blended educational environment in a HEI, D5.2 Developed LA models with accompanying use case descriptions using metadata descriptors defined under objective 1.]]></summary_en></project><project>
<id>10296</id><title_hr><![CDATA[Perinatalni biomarkeri normalnog i abnormalnog razvoja mozga kod nedonoščeta prikazani strukturnom i difuzijskom magnetskom rezonancijom ]]></title_hr><title_en><![CDATA[Perinatal biomarkers of normal and abnormal preterm infant brain development indicated by the structural and diffusion MRI]]></title_en><user_id>4298</user_id><user_firstLast_name>Milan Radoš</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2020-02</proposal_call><code>IP-2020-02-7166</code><acronim><![CDATA[PERINEDO-MR]]></acronim><duration>02.03.2021 - 01.06.2025</duration><status>Završio</status><financ_value>114.555,71 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Kliničke medicinske znanosti, Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Clinical sciences, Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>12951, 6534, 22457, 29245, 12564, 22464, 855342, 855327, 855331, 12740, 23501, 23535, 23700, 25350, 25408, 862788, </team_members_id><team_members_names><![CDATA[Ivica  Kostović, Marko Radoš, Iris Žunić Išasegi , Andrea Blažević, Ana Katušić, Tomislav Gojmerac, Finn Lennartsson, Jelena Božek, Iva Vukšić, Mirna  Kostović Srzentić , Tomislav Ćaleta, Ruža Grizelj, Nada Sindičić Dessardo, Ana Bogdanić, Gabriela Plosnić, Karlo Stemberger, ]]></team_members_names><keywords_hr><![CDATA[perintalni razvoj mozga, nedonoščad, magentska rezonancija, neuroradiološki biomarkeri, neurorazvojni ishod, perintalne lezije mozga]]></keywords_hr><keywords_en><![CDATA[perintala brain development, preterms, magentic resonance, neuroradiological biomarkes, developmental outcome, perinatal brain lesions]]></keywords_en><summary_hr><![CDATA[Smatramo kako bolja interpretacija strukturnog i difuzijskog  MR pregleda može pomoći u prepoznavanju  perintalnih lezija kod nedonoščadi i prije nego se pojave kliničke manifestacije motoričkih, osjetnih ili kognitivnih poremećaja. Svjesni smo naravno kako strukturni MR ipak ima ograničenja te ne može pouzdano vizualizirati diskretna strukturno-funkcijska odstupanja koja mogu imati značajna učinak na neurorazvojni ishod. Stoga očekujemo kako će primjena i naknadna analiza state-of-the-art difuzijskih i visokorezolucijskih T1 i T2 sekvenci dodatno povećati osjetljivost i specifičnost perinatalnog MR pregleda za poremećaje koji nisu dostupni vizualnoj inspekciji (mikrostruktura i povezanost bijele tvari, intrakortikalna mijelinizacija, debljina korteksa i sl. ).Znanstveno-klinički cilj našeg istraživanja je na perinatalnom strukturnom i funkcijskom MR pregledu definirati neuroradiološke biomarkere normalnog i abnormalnog razvoja mozga. Ovi biomarkeri će pomoći u pravovremenom prepoznavanju nedonoščadi koja će trebati ranu terapijsku intervenciju za koju je dokazano kako značajno poboljšava ukupni neurorazvojni ishod kod ove neurorizične skupine djece. Smatramo stoga kako je navedeno istraživanje vrlo bitno i na razini pojedinca i na razni cijeloj društva jer stvara okvir da se neurorizičnoj skupini  prijevremeno rođene djece osigura najbolja dijagnostička i terapijska skrb što će povećati njihove šanse za samostalan i kvalitetan život.]]></summary_hr><summary_en><![CDATA[We believe that it is possible to significantly improve the sensitivity and specificity of structural i diffusion perinatal MR imaging for perintal lesions in preterms, particularly the ones occurring in intensive development processes zones (sagittal strata, subplate zone, white matter crossroad zone). We expect a better interpretation of the structural MRI to help us identify developmental disorders before the onset of clinical manifestations of motor, sensory or cognitive disorders. We are fully aware that structural MRI has limitations and cannot accurately visualize the discrete structural and functional deviations that can ultimately impact the neurodevelopmental outcome. We, therefore, expect the application and subsequent analysis of state-of-the-art diffusion and hi-res T1 and T2 sequences to additionally increase the sensitivity and specificity of the perinatal MR images of disorders that are unavailable for visual inspection (white matter mictrostructure and connectivity, intracortical myelination, cortical thickness, etc.). The scientific-clinical objective of our research is to define neuroradiological biomarkers of normal and abnormal brain development at perinatal structural and diffusion MRI examinations. These biomarkers would help to timely identify preterm infants that are going to require early intervention therapy, which has been proven to significantly improve the overall neurodevelopmental outcome of children at neurological risk. Therefore, we consider the said research to be very relevant both on the level of an individual and the society as a whole because it would create a framework that ensures preterm children at high neurological risk the best diagnostic and therapeutic care which increases their chances for an independent and high quality life. ]]></summary_en></project><project>
<id>10300</id><title_hr><![CDATA[Autonomni sustav bespilotnih letjelica za traženje i spašavanje na moru]]></title_hr><title_en><![CDATA[Autonomous UAV system for oceanic search and rescue]]></title_en><user_id>26140</user_id><user_firstLast_name>Stefan Ivić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2020-02</proposal_call><code>UIP-2020-02-5090</code><acronim><![CDATA[AOSeR]]></acronim><duration>01.02.2021 - 31.01.2026</duration><status>U tijeku</status><financ_value>193.038,18 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Interdisciplinarne tehničke znanosti, Elektrotehnika, Računarstvo, Strojarstvo, Zrakoplovstvo, raketna i svemirska tehnika, Temeljne tehničke znanosti, </scie_field_hr><scie_field_en>Interdisciplinary technological sciences, Electrical engineering, Computer sciences, Mechnical engineering, Aerospace, missile and space engineering, Basic engineering sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Tehnički fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Engineering]]></institution_en><team_members_id>855324, 865251, 865250, 869846, </team_members_id><team_members_names><![CDATA[Ante Sikirica, Luka Lanča, Karlo Jakac, Stella Dumenčić, ]]></team_members_names><keywords_hr><![CDATA[bespilotne letjelice, više-agentno pretraživanje, kontrola gibanja, detekcija meta, strujanje morske površine]]></keywords_hr><keywords_en><![CDATA[UAV, multi-agent search, motion control, target detection, sea surface flow]]></keywords_en><summary_hr><![CDATA[Korištenje bespilotnih letjelica (UAV) u misijama pretraživanja ima brojne prednosti, uključujući manevrabilnost, smanjenje ljudskog rizika i ekonomičnost. Primjena algoritama pretraživanja osigurava prostor za razvoj i korištenje najsuvremenijih metoda koje uvelike mogu povećati performanse pretraživanja. Pri traženju nestacionarnog cilja, poput osobe koja pluta u moru, razmatranje njegove dinamike kretanja presudno je za uspjeh pretraživanja. Predlažemo da se ispita primjenjivost nove metode pokrivanja područja i sustava detekcije i osjetila na problem pretraživanja u oceanskim okruženjima. Za metodu pokrivanja područja namjeravamo upotrijebiti HEDAC (pokrivanje područja pogonom toplinske jednadžbe) koja se pokazala kao jedan od najnaprednijih algoritama za heterogenu kontrolu više agenata u stacionarnim uvjetima. HEDAC bi trebao omogućiti pretraživanje nestacionarne distribucije meta s upotrebom više agenata. Planiramo koristiti više UAV-ova s heterogenom senzorskom opremom i parametrima leta. To će biti UAV-ovi s rotacijskim krilima opremljeni kamerama vizualnog i infracrvenog spektra. Vizualno otkrivanje i robusno praćenje ciljeva može se postići korištenjem nadziranih ili polu-nadziranih dubokih konvolucijskih i ponavljajućih neuronskih mreža. Predložena istraživanja uključuju dvije vrste eksperimenata. Prvi bi eksperiment bio osnovni scenarij pretraživanja sa stacionarnim ciljevima. U drugom pokusu, koji je izvedivo pretraživanje na moru, UAV će morati samostalno detektirati plutajuće ciljeve, prateći tako ažuriranu pokrivenost cilja u stvarnom vremenu. Brzina morske površine kontinuirano će se mjeriti pomoću raspršenih plutača s GPS-om, koje će se koristiti za hranjenje sustava predviđanja strujanja mora baziranog na strojnom učenju. Budući da se konvencionalno pretraživanje oslanja na pretpostavke stalne i ujednačene raspodjele ciljeva, predloženi postupak trebao bi predstavljati značajno poboljšanje metodologije pretraživanja.]]></summary_hr><summary_en><![CDATA[The utilization of Unmanned Aerial Vehicles (UAVs) in search missions has many advantages, including maneuverability, human risk reduction and cost effectiveness. The application of search  algorithms provides aspace to develop and use state-of-the-art methods which can greatly increase the performance of the search. When searching for a non-stationary target, such as a person floating in the sea, the consideration of its movement dynamics is critical to search success. We propose to test the applicability of a novel area coverage method and target detection and sensing system on the problem of searching in oceanic environments. For the area coverage method we intend to use HEDAC (Heat Equation Driven Area Coverage) method which has shown to be one of the most advanced algorithms for heterogeneous multi-agent control in steady conditions. HEDAC should allow the search for unsteady target distribution with the use of multiple agents. We plan to use multiple UAVs with heterogeneous sensing equipment and flight parameters. These will be rotary-wing UAVs equipped with visual and infrared spectrum cameras. Visual detection and robust tracking of targets can be accomplished by making use of supervised or semi-unsupervised deep convolutional and recurrent neural networks. The proposed research comprises two types of experiments. The first experiment would be a ground search scenario with stationary targets. In a second experiment, which is a feasible search at sea scenario, UAVs will need to detect floating targets autonomously, while following the real-time updated goal area coverage. Sea surface velocity will be continuously measured by use of scattered floating GPS-enabled buoys, which will be used for feeding a machine learning sea flow predictor system. Since conventional search relies on the presumptions of steady and uniform distribution of targets, the proposed procedure should represent a significant improvement in the search methodology.]]></summary_en></project><project>
<id>10312</id><title_hr><![CDATA[Zapadnoistarska antiklinala kao idealni prirodni laboratorij za proučavanje regionalnih diskordancija u karbonatnim stijenama]]></title_hr><title_en><![CDATA[]]></title_en><user_id>2669</user_id><user_firstLast_name>Goran Durn</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-1011</code><acronim><![CDATA[WIANLab]]></acronim><duration>13.10.2020 - 12.10.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Geologija, </scie_field_hr><scie_field_en>Geology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Rudarsko-geološko-naftni fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mining, Geology and Petroleum Engineering]]></institution_en><team_members_id>856264</team_members_id><team_members_names><![CDATA[ Doktorand: Ivor Perković ]]></team_members_names><keywords_hr><![CDATA[Karbonatna sukcesija, regionalna diskordancija, paleotlo, klasifikacija, dijageneza, paleookoliš, paleoklima, Istra]]></keywords_hr><keywords_en><![CDATA[Carbonate succession, regional unconformity, palaeosol, classification, diagenesis, palaeoenvironment, palaeoclimate, Istria]]></keywords_en><summary_hr><![CDATA[Istraživanje paleotala (Pt) vezanih uz karbonatne sukcesije izuzetno je propulzivna tema u geoznanostima s aktualnim istraživanjima koja imaju za cilj pronalaženje novih i razvijanje postojećih primjena Pt, kao što su npr. rekonstrukcija paleookoliša i paleoklime, transformacija i alteracija pedogenetskih minerala tijekom procesa zalijeganja,  te uspostavljanje geokronologije terestričkih sedimenata. Cilj projekta je istražiti Pt povezana s četiri regionalne diskordancije (RD) u plitkovodnim marinskim karbonatnim sukcesijama Zapadnoistarske antiklinale kao indikatore paleookoliša, paleoklime i provenijencije. Istraživanja će obuhvatiti Pt i s njima asocirane sedimente, koji uključuju paleookršenu podinu te krovinu paleotala. Tako zajednički istraženi slijed sedimenata i Pt može pružiti cjelovitu informaciju o nastanku Pt. Istraživanje  će biti organizirano s fokusom na (a) Pt povezana s RD donji kimeridž–gornji titon, (b) Pt povezana s RD gornji apt–gornji alb, (c) Pt povezana s RD gornji cenoman/gornji santon–donji eocen, (d) Pt povezana s RD gornji eocen do danas i (e) silicijske dijagenetske sedimente  (SDS) u gornjoalbskim karbonatima. Svaka RD i SDS biti će zastupljeni s tri do četiri lokaliteta. Istraživanju Pt pristupiti ćemo visokorezolucijski, što uključuje detaljne analize petnaest atributa po dubini profila.  Nakon obavljenih analiza, Pt će biti klasificirana i njihovo formiranje interpretirano. Kombinacija povoljnih taložnih okoliša koji su rezultirali dobro definiranim stratigrafskim hijatusima duljeg trajanja i vrlo blage naknadne tektonike u Zapadnoistarskoj antiklinali omogućili su formiranje idealnog prirodnog laboratorija za multidisciplinarno istraživanje RD u karbonatnim stijenama. Smatramo da će rezultati WIANLab-a biti važan doprinos istraživanoj temi, te da imaju dobar potencijal za buduća, uglavnom primijenjena istraživanja (npr. REE u boksitima, koncept terroira).]]></summary_hr><summary_en><![CDATA[Investigation of palaeosols (Ps) related to carbonate successions is a global endeavour in geosciences, with active work that presents a variety of new and developing applications such as the utility of Ps for reconstructing palaeoenvironments and paleoclimates, the transformation and alteration of pedogenic minerals, and the establishment of geochronology within terrestrial sedimentary strata. The project goal is to investigate Ps related to the four regional unconformities in the shallow marine carbonate successions within the Western Istrian Anticline (WIA) as indicators of palaeoenvironments, palaeoclimates and provenance. Ps and deposits around them (palaeokarstified bedrock and immediate cover) as a unique package that only as a whole gives complete information on the Ps genesis will be studied. The work will be organized with the focus on (a) Ps related to the Lowermost Kimmeridgian–Upper Tithonian regional unconformity (RU), (b) Ps related to the  Upper Aptian–Upper Albian RU, (c) Ps related to the Upper Cenomanian/Upper Santonian–Lower Eocene RU, (d) Ps related to the Upper Eocene–Recent RU and (e) quartz-rich diagenetic sediments (QRDS) within the Upper Albian carbonate rocks. Each RU and  QRDS will be represented with three to four locations. High-resolution depth approach to investigation of Ps including detailed analysis of 15 attributes will be applied. After all attributes are accomplished, Ps will be classified and their formation interpreted. Combination of favourable depositional environments resulting in well-defined stratigraphic hiatuses of long duration and very gentle post-depositional tectonics in the WIA enabled formation of the ideal natural laboratory (NLab) for multidisciplinary study of RU in carbonate rocks. We find that WIANLab&#39;s results will be an important contribution to the research topic and that they have a good potential for future, mainly for the applied investigations (e.g. REE in bauxites, concept of terroir).]]></summary_en></project><project>
<id>10313</id><title_hr><![CDATA[Posljednji neandertalci na razmeđu srednje Europe i Mediterana]]></title_hr><title_en><![CDATA[]]></title_en><user_id>7676</user_id><user_firstLast_name>Ivor Karavanić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-2576</code><acronim><![CDATA[NECEM]]></acronim><duration>19.10.2020 - 19.04.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Arheologija, </scie_field_hr><scie_field_en>Archeology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>26010</team_members_id><team_members_names><![CDATA[ Doktorand: Marko Banda ]]></team_members_names><keywords_hr><![CDATA[neandertalci, rani moderni ljudi, musterijen, orinjasijen, Hrvatska]]></keywords_hr><keywords_en><![CDATA[Neandertals, early modern humans, Mousterian, Aurignacian, Croatia]]></keywords_en><summary_hr><![CDATA[Projektom je predložen opsežan interdisciplinaran pristup, koji uključuje širok opseg stručnjaka, s ciljem prikupljanje novih, raznolikih podataka o srednjem i ranom gornjem paleolitiku Hrvatske. Pomoću terenskog i laboratorijskog rada, projekt će baciti novo svjetlo na biokulturnu evoluciju čovjeka u južnom dijelu srednje Europe i središnjem dijelu Mediterana. To uključuje dobivanje precizne kronologije prijelaza srednjega na gornji paleolitik u kontinentalnoj i jadranskoj Hrvatskoj te potpunije razumijevanje odnosa između neandertalaca i ranih modernih ljudi tijekom prijelaznog razdoblja u srednjoj Europi i na Mediteranu. Nadalje, usporedbom ponašanja neandertalaca između dvije različite paleoekološke zone (kontinentalne i jadranske) otvorit će se jedinstvena perspektiva za tumačenje prilagodbe tih ljudi. ]]></summary_hr><summary_en><![CDATA[A comprehensive interdisciplinary approach is proposed by this project, involving  a wide range of professionals to obtain a variety of new data on the Middle and early Upper Paleolithic of Croatia. Employing both field and lab work, the project will shed new light on human biocultural evolution in south Central Europe and Central Mediterranean. This will involve obtaining a high resolution chronology of the Middle/Upper Paleolithic interface in both continental and Adriatic Croatia and provide a more complete understanding of the relationships between Neanderthals and early modern humans during the transitional period in Central Europe and the Mediterranean. Furthermore, comparison of Neandertal behaviour between two different paleoecological zones (Continental and Adriatic) will contribute a unique perspective on Neandertal adaptations.]]></summary_en></project><project>
<id>10331</id><title_hr><![CDATA[Razumijevanje pojavnosti kemijskih vrsta bakra i redoks transformacija u morskoj vodi]]></title_hr><title_en><![CDATA[Understanding copper speciation and redox transformations in seawater]]></title_en><user_id>561</user_id><user_firstLast_name>Elvira Bura-Nakić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IPCH</proposal_type><proposal_call>2020-10</proposal_call><code>IPCH-2020-10-4965</code><acronim><![CDATA[SeCuTrans]]></acronim><duration>01.12.2021 - 30.11.2024</duration><status>Završio</status><financ_value>187.953,55 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Interdisciplinarne prirodne znanosti, Geologija, </scie_field_hr><scie_field_en>Interdisciplinary natural sciences, Geology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>12557, 855935, 855953, 290, 866736, 23224, 19764, 869793, </team_members_id><team_members_names><![CDATA[Dario Omanović, Vladimir Sladkov, Soma Vesztergom, Marija Marguš, Dora Crmarić, Saša Marcinek, Nuša Cukrov, Narda Stipanović, ]]></team_members_names><keywords_hr><![CDATA[bakar, kemijske vrste, redoks, transformacije, more]]></keywords_hr><keywords_en><![CDATA[copper, speciation, redox, transformations, seawater]]></keywords_en><summary_hr><![CDATA[Bolje razumijevanje redoks i kemije kompleksiranja metala u modernom oceanu od važnosti je za rekonstrukciju prošlosti našeg planeta. Određivanjem koncentracije i izotopnog sastava metala u sedimentima i sedimentnim stijenama istaloženim u Zemljinoj prošlosti - i usporedbom tih podataka s modernim studijama - može se steci uvid o prošlom stanju okoliša kao i o razini kisika u drevnom oceanu. Cilj ovog prijedloga je razviti i primijeniti sveobuhvatan skup analitičkih alata u svrhu istraživanje redoks transformacije bakra (Cu), relativno slabo istraživanog metala imajuci u vidu paleo rekonstrukcije, u matriksu morske vode. Prijedlog se oslanja na sinergiju jedinstvenih vještina podnositelja projektnog prijedloga: jedne od najboljih grupa u području izotopne geokemije na svijetu (ETH Zürich) i skupine vještih znanstvenika za okoliš s (Instituta Ruđer Bošković iz Zagreba), s dugogodišnjim iskustvom u području određivanja vrsta elemenata u tragovima i geokemije istih. Cu je vec prepoznat kao potencijalno značajan alat za rekonstrukciju rezine ksika u atmosferi i oceanu u Zemljinoj prošlosti. Nedavna komparativna analiza Cu i njegovih izotopa u modernim sedimentima i arhejskim škriljevcima otkrila je potencijalnu važnost značajnog rezervoara Cu(I) u drevnoj morskoj vodi. Do sada svi pokušaji određivanja izotopne Cu bilance u modernom oceanu  pretpostavljaju prisutnost Cu(II) te mogućnost prisustva Cu  obliku Cu (I) se uglavnom zanemaruje. Ovdje izlažemo hipotezu da je uloga redoks transformacija Cu važnija od prethodno priznatog i može igrati važnu ulogu u geokemiji Cu, čak i u dominantno oksičnim sredinama kao što su moderni oceani. U ovom izazovnom i novom projektu predviđa se razvitak analitičkih alata u vrhu analiza Cu redoks vrata u vrlo zahtjevnom matriksu morske vode. ]]></summary_hr><summary_en><![CDATA[Understanding the redox and complexation chemistry of metals in modern oceanic environments is useful for reconstructing the past of our planet. By determining the abundance patterns and isotope compositions of metals in sediments and sedimentary rocks in Earth history - and by comparing these data with modern studies - we can access information on the past environmental chemistry of such metals, and gain insight into the oxygen levels of the ancient oceans. The objective of this proposal is to develop and apply a comprehensive set of analytical tools in order to study the redox transformations of copper (Cu), a relatively under-studied metal with respect to Earth history. The proposal relies on a synergy of unique skills of the two applicants: one of the top isotope geochemistry groups in the world (ETH Zürich), and a group of skilled environmental scientists (Ruđer Bošković Institute), with long experience in the field of aquatic geochemistry and trace element speciation. Cu has already been mooted as a potential proxy for the reconstruction of oceanic and atmospheric oxygen levels during Earth’s history. A recent analysis of Cu and its isotopes in modern Peru Margin sediments and Archean shales revealed the potential importance of a significant Cu(I) reservoir in ancient seawater. So far, all modern budgetary isotopic considerations have assumed the presence of only Cu(II), and the possibility of Cu being present in the form of Cu(I) is generally ignored. Here, we put forward the hypothesis that the role of Cu redox transformations is more important than previously recognized, and can play key role in the geochemistry of Cu, even in fully oxidized environments such as the modern oceans. In a challenging and novel project, we seek to develop analytical tools in order to measure copper redox speciation in a highly demanding matrix of seawater. ]]></summary_en></project><project>
<id>10334</id><title_hr><![CDATA[Mehanizmi imunološkog prepoznavanja u jetri i njihova uloga u razvoju nealkoholnog steatohepatitisa]]></title_hr><title_en><![CDATA[Mechanisms of hepatic immuno-sensing and their role in development of non-alcoholic steatohepatitis]]></title_en><user_id>7082</user_id><user_firstLast_name>Bojan Polić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IPCH</proposal_type><proposal_call>2020-10</proposal_call><code>IPCH-2020-10-8440</code><acronim><![CDATA[MITRAS]]></acronim><duration>01.11.2021 - 31.10.2025</duration><status>Završio</status><financ_value>199.084,21 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, Clinical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Medicine]]></institution_en><team_members_id>856077, 856079, 25199, 19672, 869756, </team_members_id><team_members_names><![CDATA[Sanja Mikašinović, Karlo Mladenić, Ante Benić, Maja Lenartić, Tomislav Glavan, ]]></team_members_names><keywords_hr><![CDATA[Nealkoholni steatohepatitis, fagociti, upala, fibroza, imunologija, stanice urođene imunosti, imunološko prepoznavanje]]></keywords_hr><keywords_en><![CDATA[Non-alcoholic steatohepatitis, phagocytes, inflammation, fibrosis, immunology, innate immune cells, immuno-sensing]]></keywords_en><summary_hr><![CDATA[Nealkoholna masna bolest jetre (NAFLD) je jedna od najprevalentnijih komplikacija u debljini koja pogađa više od 25% svjetske populacije. NAFLD je spektar kliničkih entiteta od jednostavne steatoze do nealkoholnog steatohepatitisa (NASH) i ciroze. Trenutno je NAFLD vodeći uzrok transplantacije jetre u zapadnom svijetu, no još uvijek je dosta toga nepoznato u njegovoj patofiziologiji. Posebno se ističe pitanje što to potiče tranziciju od jednostavne steatoze do NASH-a, a koje je od velike kliničke važnosti. U ovom projektu mi ćemo identificirati upalne poticatelje na hepatocitima koji aktiviraju imunološke stanice i započinju NASH u jetri u odgovoru na metabolički stres. Hrvatski tim će koristiti već uspostavljeni mišji model za nealkoholnu masnu bolest jetre te će implementirati svoja znanja i ekspertize u nadzoru metaboličkog stresa od strane imunološkog sustava. Švicarski tim će koristiti analizu populacija imunoloških stanica visoko-parametarskom protočnom citometrijom kako bi karakterizirao promjene u njihovom fenotipu i funkciji u kontekstu NASH-a, sa posebnim fokusom na fagocite. Upotrebom ovoga sustava, tim će vizualizirati kompleksnost imuno-patologije u NAFLD sa vrlo visokom rezolucijom. Kombinacijom napora, hrvatski i švicarski tim će biti u mogućnosti povezati svoje studije u jedinstvenu studiju koja će generirati kompletnu sliku ranih procesa u upali jetre. Naš konačni cilj je identifikacija potencijalnih novih ciljeva u terapiji NASH-a. Ujedno, ovaj projekt predstavlja i jedinstvenu priliku mladim hrvatskim istraživačima za stjecanje znanja i ekspertiza u najnaprednijim tehnologijama koje se koriste u imunologiji. Sveukupno, mi vjerujemo da ovaj projekt predstavlja izvrsnu investiciju u Švicarsko-hrvatsku znanstvenu suradnju i prijateljstvo.]]></summary_hr><summary_en><![CDATA[Non-alcoholic fatty liver disease (NAFLD) is one of the most prevalent complications of obesity, affecting more than 25% of the global adult population. NAFLD is a spectrum of clinical entities, ranging from simple steatosis to non-alcoholic steatohepatitis (NASH) and cirrhosis. Already NAFLD is the leading cause of liver transplantation in the western world, yet still much is unknown about its underlying pathophysiology. Especially the question what drives the transition from simple steatosis to NASH is of great clinical importance. In the project described here, we will identify the inflammatory triggers on hepatocytes that activate hepatic immune cells and initiate NASH in liver in response to metabolic stress.  The Croatian team will make use of its established murine models for fatty liver disease and will implement its know-how on surveillance of metabolic stress by the innate immune system. The Swiss team will make use of high parameter flow cytometric analysis of immune cell  populations to characterize changes in their phenotype and function in context of NASH, with a special focus on Phagocytes. Using this system, they will  visualize the complexity of the immuno-pathology in NAFLD at an unprecedented resolution. By combining forces, the Croatian and Swiss teams will be able to link their studies into a single project that will generate a complete picture of early processes in liver inflammation. Our ultimate goal is to identify potential new targets for treatment of NASH. In addition, this project provides a unique opportunity for young Croatian researchers to gain know-how on the latest technological developments in the field of immunology. We therefore believe that this project is an excellent investment in Swiss-Croatian science and friendship. ]]></summary_en></project><project>
<id>10337</id><title_hr><![CDATA[Brzi prekidački pretvornici zasnovani na GaN elementima i rezonantnim arhitekturama]]></title_hr><title_en><![CDATA[]]></title_en><user_id>7714</user_id><user_firstLast_name>Adrijan Barić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2020-01</proposal_call><code>DOK-2020-01-2073</code><acronim><![CDATA[FASCON]]></acronim><duration>01.10.2020 - 31.08.2023</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>26443</team_members_id><team_members_names><![CDATA[ Doktorand: Alma Traživuk ]]></team_members_names><keywords_hr><![CDATA[prekidački pretvornik, GaN, galij-nitrid, rezonantni pretvornik, integrirani sklop, čip ]]></keywords_hr><keywords_en><![CDATA[switching converter, GaN, gallium-nitride, resonant converter, integrated circuit, chip]]></keywords_en><summary_hr><![CDATA[Prekidački pretvornici vrlo su značajni u modernoj elektronici za prenosive uređaje i za automobilsku elektroniku zbog njihove visoke efikasnosti. Kroz ovaj projekt razvijaju se metode za smanjenje generiranih elektromagnetskih (EM) smetnji kod rezonantnih pretvornika dok se u isto vrijeme održava visoka efikasnost. Analizira se više pristupa. Korištenje tehnike raspršenog spektra poboljšava elektromagnetsku kompatibilnost (EMC), ali može narušiti druge karakteristike pretvornika, npr. efikasnost. Modulacija s raspršenim spektrom je u komercijalnim pretvornicima uobičajeno fiksirana i njeni parametri se ne mogu podešavati. Korištenjem konfigurabilne modulacije raspršenog spektra mogu se smanjiti EM emisije bez žrtvovanja ostalih karakteristika. Drugo, korištenje galij-nitrid (GaN) tranzistora u prekidačkim pretvornicima umjesto silicijskih tranzistora smanjuje gubitke i omogućava rad pretvornika na višim prekidačkim frekvencijama. Zatim se istražuje utjecaj omjera ulaznog i izlaznog napona na efikasnost i EM emisije kod pretvornika koji rad ne visokim prekidačkim frekvencijama i koji se sastoje od više stupnjeva. Mjerenja prekidačkih pretvornika vrlo su zahtjevna, prije svega zbog mjerenja tranzistora na gornjoj strani, a osim toga i mjerenja EM smetnji. U ovom projektu razvija se cjelovito elektro-optičko mjerno okruženje za karakterizaciju elektromagnetske kompatibilnosti i mjerenje prekidačkih tranzistora. Provodi se analiza elektro-optičkog sustava kroz procjenu karakteristika te korisnosti pri mogućem komercijalnom korištenju sustava. Predloženo istraživanje ispituje metode optimiranja efikasnosti prekidačkih pretvornika snage uz održavanje elektromagnetskih emisija unutar dozvoljenih granica korištenjem novih elektroničkih elemenata i arhitektura istosmjernih pretvornika snage.]]></summary_hr><summary_en><![CDATA[Switching converters are very important in modern electronics because of their high efficiency in portable applications and in automotive electronics. This project aims to provide the methods for the reduction of the generated electromagnetic (EM) interference of the resonant converters while keeping their high efficiency. Several approaches are analyzed. Utilization of a spread-spectrum technique improves electromagnetic compatibility (EMC), but it may deteriorate other characteristics of the converter, e.g. the efficiency. The spread-spectrum modulation in commercially available converters is usually fixed and its parameters are not user-configurable. Having a configurable spread-spectrum modulator allows  fine tuning and reduction of  generated EM emissions without having to sacrifice the performance. Secondly, using gallium-nitride (GaN) transistors in switching power converters instead of silicon ones leads to lower power losses and operation of the converters at even higher switching frequencies. Thirdly, the investigation on the impact of the voltage conversion ratio on power efficiency and electromagnetic emissions in the high-frequency multi-stage DC-DC converter chain is performed. Finally, measurements of switching converters are very demanding, firstly because of the measurements of the high side transistors and secondly because of strong conducted and radiated electromagnetic emissions. In this project, an entire electro-optical measurement environment for characterization of electromagnetic compatibility and measurement of transistor switches is developed and its usage is fully assessed from the viewpoint of technical specifications and commercial usefulness. The proposed research investigates the methods for optimization of power efficiency of switching power supplies while meeting the acceptable levels of electromagnetic emissions using novel device technologies and architectures of DC-DC power converters.]]></summary_en></project><project>
<id>12396</id><title_hr><![CDATA[Prepoznavanje neurostrukturalnih, neurofunkcionalnih, kognitivnih i bihevioralnih pokazatelja zahvaćenosti mozga u COVID-19 i pokazatelji ishoda tijekom longitudinalnog praćenja]]></title_hr><title_en><![CDATA[Detection of neurostructural, neurofunctional, cognitive and behavioural indicators of brain invasion in COVID-19, and predictors of outcomes in longitudinal follow-up]]></title_en><user_id>5929</user_id><user_firstLast_name>Neven Henigsberg</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP-CORONA</proposal_type><proposal_call>2020-12</proposal_call><code>IP-CORONA-2020-12-5588</code><acronim><![CDATA[BrainCov19]]></acronim><duration>27.09.2021 - 26.09.2023</duration><status>Završio</status><financ_value>150.465,91 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Clinical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>12951, 682, 2684, 6104, 26539, 5854, 4298, 4359, 5007, 21453, 146, 19729, 861541, 12740, 5845, 13311, 1093, 23941, 855327, 6937, 7090, 24269, 861627, 12680, 23386, 7560, 7627, 861603, 861608, 18918, 25356, 3718, 861566, 6534, 5185, 7740, 7088, 13638, 5625, 23706, 1189, 862793, 862789, 23710, 7381, 7272, 867646, </team_members_id><team_members_names><![CDATA[Ivica  Kostović, Marijan Klarica, Fran Borovečki, Vladimir Bedeković, Andro Košec, Dina Šimunić, Milan Radoš, Marijan Palmovic, Nada Božina, Marija Santini, Antonio Petošić, Hrvoje Tiljak, Tomislav Breitenfeld, Mirna  Kostović Srzentić , Viktorija Erdeljić Turk, Aleksandar Savić, Šime Zekan, Mario Šekerija, Jelena Božek, Helena Šarac, Petra Kalember, Jakša Vukojević Vukojević, Ana Šečić Šečić, Branka Bartolić Spajić, Damir Mulc, Domagoj Vidović, Jasenka Markeljević, Danijela Zakic Milas, Davor Sporiš, Krešimir Ćosić, Lana Vasung, Joško Mitrović, Goran Ivkić, Marko Radoš, Mirjana Kujundžić Tiljak, Miloš Judaš, Pero Hrabač, Benedict Rak, Zdravka Poljaković, Radovan Radonić, Ivica Lukšić, Alan Anticevic Anticevic, Dimitri Krainc, Ante Bilić Prcić, Petrana Brečić, Darko Marčinko, Tamara Foro, ]]></team_members_names><keywords_hr><![CDATA[COVID-19, SARS-Cov-2, CNS, mozak, klinička neuroznanost, obrazac kretanja simptoma, psihijatrija, neurologija, neuroinfekcija]]></keywords_hr><keywords_en><![CDATA[COVID-19, SARS-Cov-2, CNS, brain, clinical neuroscience, trajectories of symptoms, psychiatry, neurology, neuroinvasion]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Presumable transsynaptic transfer cause neuropsychiatric manifestations in 22.5% patients of all COVID-19 severities. Transolfactory spread may represent a distinct pattern of invasion with more likely detrimental outcome to emotional, memory, decision making, and other higher cognitive processing. We aim to prove CNS involvement in the spread of SARS-CoV-2 by displaying brain structural, functional, and neuropsychiatric and cognitive behavioural correlates of neuronal affection in vivo, and to map the interlink of their phenomenologies. We hypothesize that synergy of approaches is a sensitive and specific method to detect and predict different trajectories in clinical presentation and outcomes and that transneural spread with primary point of entry in olfactory tract leads to more severe brain invasion. Identification of markers of brain invasion may result in increased treatment potential and in improved prevention strategies.Our research will include three study groups: 1. 40 COVID-19 patients exhibiting neuropsychiatric and/or cognitive residua (1a) With anosmia; (1b) Without anosmia; 2. 40 COVID-19 patients not exhibiting neuropsychiatric and/or cognitive residua (2a) With anosmia; (2b) Without anosmia, 3. 30 Healthy controls. Presence of CNS-related COVID-19 pathological substrate will be evaluated by magnetic resonance imaging protocols (T1 and T2, 3D magnetization prepared rapid gradient-echo imaging, functional MR imaging, proton magnetic resonance spectroscopy and diffusion-tensor imaging) at baseline and 1 year later. COVID-19-related symptoms and psychometric and neurological parameters will be tracked continuously by validated rating scales and by structured clinical interviews.We expect to prove CNS involvement in SARS-CoV-2 by displaying differences in parameters of structure and/or function between COVID-19 patients, stratified by anosmia, and after adjustment for severity of disease and inflammation, in comparison with unaffected matched controls. ]]></summary_en></project><project>
<id>12402</id><title_hr><![CDATA[Promjene u organizaciji procesa odgoja i obrazovanja uzrokovane COVID-19 pandemijom: učinci na obrazovna iskustva, dobrobit i aspiracije učenika u Republici Hrvatskoj]]></title_hr><title_en><![CDATA[Changes in the Organisation of Educational Processes Induced by the COVID-19 Pandemic: Effects on Croatian Pupils&#39; Educational Experiences, Wellbeing and Aspirations over Time]]></title_en><user_id>861</user_id><user_firstLast_name>Boris Jokić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP-CORONA</proposal_type><proposal_call>2020-12</proposal_call><code>IP-CORONA-2020-12-5131</code><acronim><![CDATA[EWAchange]]></acronim><duration>23.08.2021 - 22.02.2023</duration><status>Završio</status><financ_value>58.169,17 eur</financ_value><scie_area_hr>Interdisciplinarno područje znanosti</scie_area_hr><scie_area_en>Interdisciplinary scientific area</scie_area_en><scie_field_hr>Obrazovne znanosti, </scie_field_hr><scie_field_en>Educational Sciences, </scie_field_en><institution_hr><![CDATA[Institut za društvena istraživanja]]></institution_hr><institution_en><![CDATA[Institute for Social Research in Zagreb]]></institution_en><team_members_id>862, 861542, 26732, 861605, 861580, 344, 12779, 11282, 7765, 861604, 22747, 861577, 21221, 3554, </team_members_id><team_members_names><![CDATA[Zrinka Ristić Dedić, Daniela Cvitković, Margareta Gregurović, Jasmina Ivšac Pavliša, Mojca Juriševič, Vesna Kovač, Gordana Kuterovac Jagodić, Ajana Löw, Iris Marušić, Teo Matković, Ivana Miočić, Anja Podlesek, Josip Šabić, Tena Velki, ]]></team_members_names><keywords_hr><![CDATA[organizacija procesa odgoja i obrazovanja, obrazovna iskustva, dobrobit, obrazovne aspiracije, longitudinalni sekvencijalni nacrt miješanog modela]]></keywords_hr><keywords_en><![CDATA[organisation of educational processes, educational experience, wellbeing, educational aspiration, longitudinal sequential mixed model study]]></keywords_en><summary_hr><![CDATA[U proteklih deset mjeseci, do prosinca 2020. godine, COVID-19 pandemija je značajno promijenila obrazovne procese u Republici Hrvatskoj. Nastavak neizvjesnosti o učincima pandemije na obrazovanje očekuje se i u 2021. godini. U navedenom razdoblju uvedene su različite obrazovne mjere za organizaciju obrazovnog procesa na različitim razinama obrazovanja. Organizacijske promjene koje je izazvala pandemija djelovale su na ključne aspekte obrazovnog procesa, prije svega na postavljanje obrazovnih prioriteta, izvedbu kurikuluma, pristupe vrednovanju i ocjenjivanju, okružje učenja i podršku učenicima. Promjene u tim procesima potencijalno su imale (i vjerojatno će imati i u budućnosti) izrazite posljedice na živote učenika različite dobi. Korištenjem sekvencijalnog, longitudinalnog dizajna istraživanja miješanog modela koje sadrži veliku kvantitativnu i opsežnu kvalitativnu istraživačku dionicu, predloženi projekt predstavlja sveobuhvatno znanstveno ispitivanje značajnih promjena u hrvatskom obrazovanju nastalih kao posljedica pandemije te nastoji utvrditi obrazovne i psihosocijalne učinke tih promjena na učenike, s posebnim naglaskom na promjene njihovih obrazovnih iskustava, dobrobiti i obrazovnih aspiracija. Poseban naglasak u projektu stavljen je na ispitivanje toga kako promjene u organizaciji obrazovnog procesa uzrokovane pandemijom djeluju na tri ranjive skupine: učenike s teškoćama u razvoju i teškoćama učenja, učenike iz nepovoljnog socioekonomskog okružja te darovite učenike. Rezultati istraživanja bit će relevantni ne samo kao retrospektivni osvrt na jedinstvene društvene i obrazovne događaje, već i prospektivno kao izvod uvida i preporuka za budućnost. Rezultati projekta omogućit će osmišljavanje i uvođenje mjera obrazovne politike na sustavnoj razini koje mogu ublažiti nastale poremećaje obrazovnih procesa te osnažiti učenike, odgojno-obrazovne radnike i roditelje za uspješno ovladavanje kriznim situacijama u budućnosti.]]></summary_hr><summary_en><![CDATA[As of December 2020, educational processes in Croatia have been significantly affected due to the COVID-19 pandemic over a period of 10 months. Uncertainties about the effects of the pandemic on education are expected to continue into 2021. In this period, a variety of policy options have been used in the organisation of educational processes at different educational levels. The organisational changes induced by the pandemic influenced core aspects of educational processes, particularly in setting educational priorities, curriculum delivery, assessment practices, the teaching and learning environment and support. Changes to these educational processes have potentially had (and will likely continue to have) strong effects on lives of pupils of different ages. Using a sequential, longitudinal mixed model research design with large-scale quantitative and extensive qualitative research phases, the proposed project aspires to conduct a comprehensive scientific exploration of the profound changes in Croatian education caused by the pandemic and to assess the educational and psychosocial effects of this implementation on pupils, with particular emphasis on changes to pupils’ educational experiences, wellbeing and educational aspirations. Special emphasis in the project is placed on the exploration of how changes in the organisation of educational processes affected three vulnerable groups: pupils with disabilities and learning difficulties, pupils from disadvantaged socioeconomic contexts and gifted pupils. Research findings will be relevant not only as a retrospective account of exceptional societal and educational events, but also prospectively as a source of insight and recommendations for the future. Project results will enable the design and inform implementation of system-level policy measures that could ameliorate the disruption of regular schooling and empower pupils, educational workers and parents to successfully master crisis situations in the future.]]></summary_en></project><project>
<id>12414</id><title_hr><![CDATA[Politike za jačanje otpornosti: Istraživanje uloge javnih bespovratnih sredstava]]></title_hr><title_en><![CDATA[Resilience Enhancing Policies: Exploring the Role of Public Grants]]></title_en><user_id>27231</user_id><user_firstLast_name>Stjepan Srhoj</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP-CORONA</proposal_type><proposal_call>2020-12</proposal_call><code>IP-CORONA-2020-12-1064</code><acronim><![CDATA[CROREP]]></acronim><duration>01.09.2021 - 28.02.2023</duration><status>Završio</status><financ_value>41.623,00 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, </scie_field_hr><scie_field_en>Economy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Dubrovniku]]></institution_hr><institution_en><![CDATA[University of Dubrovnik]]></institution_en><team_members_id>861632, 861636, 29482, </team_members_id><team_members_names><![CDATA[Mate Damić, Mislav Radic Radic, Ivan Žilić, ]]></team_members_names><keywords_hr><![CDATA[Mala i srednja poduzeća, poduzetništvo, potpore, organizacijska otpornost, organizacijske konfiguracije, COVID-19, ekonomska politika]]></keywords_hr><keywords_en><![CDATA[SMEs, public grants, organizational resilience, organizational configurations, COVID 19, economic policy]]></keywords_en><summary_hr><![CDATA[Ekonomske posljedice pandemije COVID-19 su potakle hrvatsku vladu da razvije niz javnih politika usmjerenih jačanju sveukupne otpornosti domaćih poduzeća. Organizacijska otpornost se odnosi na proces u kojem organizacije koriste svoje resurse i sposobnosti za interakciju s okruženjem na način koji će im omogućiti pozitivno prilagođavanje i održavanje funkcionalnosti prije, tijekom i nakon nastupa nekog neželjenog događaja. Ključne politike hrvatske vlade usmjerene jačanju otpornosti poduzeća na posljedice pandemije COVID-19 bile su mjere javnih potpora. Provođenjem dviju međusobno povezanih studija planiramo ispitati izazove i ishode povezane s politikama jačanja otpornosti. Zbog višedimenzionalnosti konstrukta organizacijske otpornosti, korištenje samo jedne metodologije te provedba jedne studije ne bi na odgovarajući način zahvatila složenost fenomena. Stoga predlažemo korištenje više metoda, provodeći jednu kvantitativnu (multivarijantna analiza) i jednu kvalitativnu (kvalitativna komparativna analiza) studiju. Istraživački projekt odgovara na poziv za analizu uloge javnih i gospodarskih politika u uvjetima pandemije u oporavku i povećanju otpornosti poduzetništva i neprofitnog sektora. Dizajn istraživanja je vrlo inovativan i nudi visoku razinu prenosivosti na slična buduća istraživanja u kontekstu organizacijske otpornosti i javnih politika. Mogućnost identificiranja ključnih čimbenika otpornosti organizacije i procjene uspjeha ekonomskih politika u povećanju otpornosti poslovnih organizacija pružit će neprocjenjive uvide za razvoj i provedbu boljih javnih i ekonomskih politika u slučaju nastupa vanjskih šokova, kao što je pandemija COVID-19. Predloženi projekt također će pružiti koristan model za učinkovita partnerstva u istraživanju i praksi, što će potencijalno omogućiti da se predloženo istraživanje proširi i na druga institucionalna okruženja.]]></summary_hr><summary_en><![CDATA[The economic consequence of the COVID-19 pandemic has triggered the Croatian government to develop a number of public policies aimed at strengthening the overall resilience of Croatian private sector organizations.  Organizational resilience refers to the process by which organizations use its resources and capabilities to interact with the environment in a way that positively adjusts and maintains functioning prior to, during, and following adversity. In order to make Croatian companies more resilient to the adversity associated with the COVID-19 pandemic, the key policy of the Croatian government was the development and implementation of a public grants scheme. By conducting two interrelated studies, we propose to examine the challenges and outcomes of resilience enhancing policies. Due to the multidimensionality of organizational resilience, a single study/methodology – as commonly used in economics, would not adequately capture the complexity of the phenomenon. Thus, we propose a multi-method approach, by conducting one quantitative and one qualitative comparative study. This research project answers the call for analysis of the role of pandemic-induced public and economic policies in the recovery and increase of resilience of the entrepreneurship and non-profit sectors. The research design itself is highly innovative and offers a high level of transferability for similar future research in the context of organizational resilience and public policy. Being able to identify key antecedents of organizational resilience and evaluate the success of economic policies in increasing the resilience of business organizations will provide invaluable insights for the development and implementation of better public and economic policies in the face of external shocks. The proposed project will also provide a useful model for effective research-to-practice partnerships, which will potentially allow for the proposed work to be extended to other institutional settings.]]></summary_en></project><project>
<id>12434</id><title_hr><![CDATA[Učenje biologije u epidemiološki prilagođenom istraživačkom okruženju ]]></title_hr><title_en><![CDATA[Learning biology in epidemiologically adapted research environment]]></title_en><user_id>26712</user_id><user_firstLast_name>Ines Radanović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP-CORONA</proposal_type><proposal_call>2020-12</proposal_call><code>IP-CORONA-2020-12-3798</code><acronim><![CDATA[BIO EPI-ADRESEN]]></acronim><duration>01.09.2021 - 28.02.2023</duration><status>Završio</status><financ_value>88.096,52 eur</financ_value><scie_area_hr>Interdiciplinarne znanosti, Prirodne znanosti, Društvene znanosti, </scie_area_hr><scie_area_en>Interdisciplinary scientific area, Natural sciences, Social sciences, </scie_area_en><scie_field_hr>Obrazovne znanosti, Biologija, Edukacijsko-rehabilitacijske znanosti, Interdisciplinarne prirodne znanosti, </scie_field_hr><scie_field_en>Educational sciences, Biology, Physical education and rehabilitation sciences, Interdisciplinary natural sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>4503, 13682, 12634, 19150, 23444, 861545, 3387, 3055, 22628, 26342, 4379, 26710, 22556, 19415, 861662, 1532, 4420, 23992, 12351, 19526, 861595, 22626, 6570, 22627, 861567, 861587, 13731, 400, 861612, 861624, 861578, 861658, 26158, 25798, 861621, 861702, 861544, 861581, 861554, 861600, 861588, 861601, 861576, 861570, 861617, 861598, 19376, 861599, 861622, 861556, 861579, 26617, 12349, 861560, 861564, 861548, 861582, 861649, 861584, 861559, 861602, 861596, 861574, 861583, 861623, 861575, 861563, 861568, 29321, 861594, 4729, 1497, 22737, </team_members_id><team_members_names><![CDATA[Ivana Ivančić Baće, Mirjana Lenček, Ivana Maguire, Mirjana Pavlica, Ivančica Ternjej, Siniša Ozimec, Sandra Radić Brkanac, Slavica  Šimić Šašić, Tanja Žuna Pfeiffer, Sonja Alimović, Senka Blažetić, Sara Essert, Anita Galir Balkić, Romana Gračan, Anđela Grgić, Ljiljana Krstin, Irena  Labak, Marina Milković, Mirela Sertić Perić, Petar Žutinić, Mirta Sudarić Bogojević, Filip Stević, Ivana Šola, Dubravka Špoljarić Maronić, Marija Babić, Diana Garašić, Sandra Kučina Softić, Jelena Kuvač Kraljević, Andreja Lucić, Žaklin Lukša Lukša, Damir Sirovina, Robert Mujkić, Tomislav Radošević, Valerija  Begić, Gabrijela Marin, Zrinjka Stančić Stančić, Mila Bulić, Filip Babić, Ana Bakarić, Marijana Bastić, Doroteja Domjanović Horvat, Vlatka Kuhar, Lydia Lugar, Julijana Madaj Prpić, Mihaela Marceljak Ilić, Jasenka Meštrović, Kristina Majsec, Ozrenka Meštrović, Zrinka Pongrac Štimac, Tona Radobolja, Martina Vidović, Božena Mitić, Renata Matoničkin Kepčija, Vesna Gulin, Ana Ćaleta, Ilijana Dominović, Stjepana Fistanić, Romana Halapir Franković, Ivana Porobija, Ana Skuhala, Mateja Srkoč, Ivan Šetin, Mihaela Štargl, Marijana Šundov, Mirjana Valjak-Porupski, Dorotea Vrbanović, Lea Zidar, Marija Žilić, Renata  Horvat, Zdenka Ivančić, Mario Dumančić, Petra Korać, Silvija Černi, ]]></team_members_names><keywords_hr><![CDATA[biology didactics, online learning, blended learning, active learning, field teaching simulation]]></keywords_hr><keywords_en><![CDATA[metodika biologije, e-učenje, hibridno učenje, aktivno učenje, simulacija terenske nastave]]></keywords_en><summary_hr><![CDATA[Glavni cilj ovog projekta je prilagoditi nastavu i učenje biologije tijekom pandemije te istražiti učinke epidemiološki prilagođenih metoda poučavanja i učenja biologije na uspjeh učenika osnovnih i srednjih škola. Konkretno, predloženi istraživački projekt će: (i) razviti visoko interaktivni model poučavanja i učenja biologije tijekom pandemije (ASIO model) namijenjen učenicima osnovnih i srednjih škola; (ii) uspostaviti platformu (BUBO platforma) koja sadrži materijale za učenje i poučavanje biologije dizajnirane prema ASIO modelu i koja bi omogućila materijale za učenje učenicima različite dobi i kategorija uspješnosti, uključujući prilagodbe za nadarene učenike i nekoliko kategorija učenika s invaliditetom i/ili poteškoćama u učenju; (iii) provesti istraživanje o učincima primjene ASIO modela na uspjeh učenika u nastavi biologije prije i nakon uvođenja modela. Usporedba učinaka ASIO modela temeljit će se na usporedbi uspjeha učenika, odnosno na usporedbi postotka riješenosti dviju pismenih provjera znanja – početne provjere (provedene prije uvođenja ASIO modela) i druge provjere (primijenjene nakon uvođenja ASIO modela). Uspjeh učenika analizirat će se prema dobi učenika i kategorijama uspješnosti (prosječnog uspjeha) učenika na uzorku od najmanje 100 učenika po razredu unutar osam razreda osnovne škole i četiri razreda srednje škole. Predviđamo da će primjena ASIO modela u biologiji poboljšati učinkovitost poučavanja i uspjeh učenika u nastavi biologije, bez obzira na prosječni uspjeh i dob učenika (razred koji pohađaju). Ako potvrdimo svoja očekivanja, predložit ćemo ASIO model kao kvalitetan alat za poučavanje bioloških sadržaja u epidemiološki prilagođenom okruženju.]]></summary_hr><summary_en><![CDATA[The main objective of this project is to adapt biology teaching and learning during pandemics, and to explore the effects of the epidemiologically adapted biology teaching and learning methods on the student performance at the primary and secondary school levels. Specifically, the proposed research project will: (i) develop a highly interactive learner-centered model (the ASIO model) for learning and teaching biology at the primary and secondary school levels during the pandemics; (ii) establish a platform (the BUBO platform) containing teaching and learning materials designed according to the ASIO model, that would offer learning materials for students of different age and performance categories at the primary and secondary school levels, including adaptations for gifted students and several categories of students with disabilities; (iii) conduct a research on the effects of the ASIO model application on the students’ performance in biology before and after the introduction of the model. The comparison of the ASIO model effects will be based on the comparison of the student performance assessed as a mean score between the two consecutive written exams - initial exam (applied before introduction of the ASIO model) and second exam (applied after introduction of the ASIO model). Student performance will be analyzed according to the student age and student performance categories (average performance) among at least 100 students per grade across eight primary school and four high school grades. We predict that the application of the ASIO model in biology will enhance teaching effectiveness and student performance, regardless of the students&#39; age (grade) and average performance. If we confirm our expectations, we will propose ASIO as a well-tailored tool for teaching biological concepts in an epidemiologically adapted environment.]]></summary_en></project><project>
<id>12457</id><title_hr><![CDATA[Procjena stanja i obnova postojećih građevina -  Razvoj suvremenih metoda za zidane i drvene konstrukcije]]></title_hr><title_en><![CDATA[]]></title_en><user_id>19909</user_id><user_firstLast_name>Mislav Stepinac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-1906</code><acronim><![CDATA[ARES]]></acronim><duration>24.11.2021 - 23.11.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Građevinarstvo, </scie_field_hr><scie_field_en>Civil engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Građevinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Civil Engineering]]></institution_en><team_members_id>865235</team_members_id><team_members_names><![CDATA[ Doktorand: Antonela Moretić ]]></team_members_names><keywords_hr><![CDATA[ocjena, ziđe, drvo, pouzdanost, obnova, konstrukcije, metode]]></keywords_hr><keywords_en><![CDATA[assessment, masonry, timber, reliabilty, rehabilitation, structures, methods]]></keywords_en><summary_hr><![CDATA[Više od 75% hrvatskog građevinskog fonda starije je od 30 godina, što predstavlja vrijeme kod kojeg je, za većinu objekata, potrebna renovacija ili rekonstrukcija. Više od 40% zgrada starije je od 50 godina što bi značilo da je uporabni vijek tih zgrada već istekao. Procjena stanja postojećih konstrukcija temelji se na identifikaciji, lokalizaciji i ocjeni propadanja i oštećenja konstrukcije. Nalazi procjene stanja temeljeni su na postupcima projektiranja novih konstrukcija i planiranje zahvata obično sugerira pojačanje konstrukcije. Trenutna praksa ne može se smatrati prikladnom za sigurnu odluku o pouzdanosti konstrukcije. Determinističke metode za vrjednovanje postojećih konstrukcija dopuštaju jednostavnu procjenu, ali pate od velikih faktora sigurnosti. Kod procjene stanja na razini pouzdanosti izbjegava se otkazivanje i nepotrebno rušenje konstrukcije, a rezultat su sigurnije konstrukcije i bolje korištenje resursa. Rješavanjem problema kao što je učinkovito određivanje svojstava konstrukcije i materijala, određivanje utjecaja opterećenja u proteklom vremenu te njegovog trajanja na ponašanje konstrukcije može biti vrijedno i od velike pomoći za projektante, kao i za istraživače i znanstvenike koji se bave procjenom stanja zidanih i drvenih konstrukcija. Cilj ovog istraživačkog projekta je istražiti ulogu procjene stanja na analizu pouzdanosti postojećih konstrukcija. Projekt će se baviti postojećim zidanim i drvenim konstrukcijama kako bi utvrdio prednosti procjene stanja u pogledu ekonomičnosti i sigurnosti konstrukcija. U projektu će se vrjednovati metode “nadogradnje” podataka za primjenu procjene stanja te će se proučavati ponašanje konstrukcija ovisno o vremenu i utjecajima uvjeta okoliša. Izradit će se smjernice s integriranim metodama pouzdanosti za projektiranje, procjenu i obnovu stanja postojećih konstrukcija te će one biti najznačajniji rezultat projekta. Rezultati projekta imat će značajan utjecaj na međunarodne norme za projektiranje konstrukcija.]]></summary_hr><summary_en><![CDATA[More than 75% of the building stock in Croatia is older than 30 years, an age often requiring renovation or modification of buildings. In addition, more than 40% of the building stock is older than 50 years meaning that the service life of the structures is expired. The assessment of existing structures focuses mainly on the identification, localization and evaluation of deterioration, decay and damage. The diagnoses are based on the design procedures of new structures and the planning of interventions. The current practice might not be considered suitable to facilitate confident decisions about the reliability of structures. Deterministic methods for the evaluation of existing structures allow for an easy evaluation but suffer from large safety factors. Reliably assessing structures avoids failures and unnecessary decommissioning, and leads to safer structures and better use of resources. Solving the issues like the determination of structural & material properties, quantification of the impact of loading history and load duration on structural performance can be valuable and precious help for designers as well as for researchers and scholars dealing with the assessment of masonry and timber structures. The aim of this research project is to study the role of assessment on the reliability analysis of existing structures. The project focuses on existing masonry and timber structures to evaluate the benefits of assessment with regard to the economy and safety of structures. Also, the project will evaluate updating methods for the application of the assessment & verification of structures and consideration of time-dependent behaviour & the influence of environmental conditions. Design guidelines and integration of reliability methods in assessment and rehabilitation of existing structures will be the main benefit of the project. The results of the project will have a decisive impact on international codes regarding structural engineering.]]></summary_en></project><project>
<id>12459</id><title_hr><![CDATA[Uloga lova i lovnog gospodarenja u širenju novonastalih populacija divljih papkara na Mediteranu]]></title_hr><title_en><![CDATA[]]></title_en><user_id>2954</user_id><user_firstLast_name>Nikica Šprem</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-8287</code><acronim><![CDATA[MedUng]]></acronim><duration>24.10.2023 - 23.06.2026</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Biotehnologija, </scie_field_hr><scie_field_en>Biotechnology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Agronomski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Agriculture]]></institution_en><team_members_id>867519</team_members_id><team_members_names><![CDATA[ Doktorand: Valentina Barukčić ]]></team_members_names><keywords_hr><![CDATA[Introdukcije, MHC, adaptabilnost, invazivnost, papkari, Grivasti skakač, Europski muflon, divlja svinja]]></keywords_hr><keywords_en><![CDATA[Introductions, MHC, adaptability, invasiveness, ungulates, aoudad, European mouflon, wild boar]]></keywords_en><summary_hr><![CDATA[Translokacije papkara u svrhu introdukcije, reintrodukcije ili nadomještanja su uglavnom motivirane lovom. Divljač se uobičajeno introducira u nova staništa kako bi se stvorile nove ili poboljšale postojeće prilike za lov, pogotovo kada se smanji brojnost autohtonih lovnih vrsta. Introducirane vrste mogu postati invazivne, pa je radi toga važno proučiti njihov utjecaj na staništa i prisutne autohtone vrste (moguću kompeticiju, prijenos uzročnika bolesti, hibridizaciju ili izmjenu staništa). U ovom istraživanju će se, kombinacijom najnovijih istraživačkih metoda iz različitih područja (genetike, genomike, biokemije, bioinformatike, GPS slijeđenja i parazitologije) prikazati detaljna slika učinka translokacija triju vrsta papkara. Grivasti skakač i europski muflon introducirane su vrste na području mediterana, dok su divlje svinje nedavno uspostavile nove populacija na nekim otocima kroz procese prirodne kolonizacije ili kroz nelegalne translokacije u svrhu lova. Integracijom podataka o neutralnim (mikrosateliti) i svojstvima povezanim sa fitnesom (MHC geni) razviti ćemo protokol koji će omogučiti procjenu statusa novonastalih populacija papkara i utjecaj aktivnosti povezanih s lovom na njihovo širenje. Ovaj pristup biti će polazište za daljna istraživanja selekcijskih procesa u izmijenjenim staništima i promjena ponašanja populacija koje se suočavaju s izmjenama u njihovim staništima. Ta saznanja su važna za razumijevanje načina na koji se divlje, ali i domaće, životinjske vrste prilagođavaju promjenama u okolišu, što je posebno važna tema u ozračju očekivanih promjena prirodnih uvjeta uvjetovanih klimatskim promjenama.  ]]></summary_hr><summary_en><![CDATA[Translocation of ungulate species with purpose of introduction, re-introduction or supplementation is mostly motivated by hunting. Wildlife is commonly introduced in new habitats to create or improve hunting opportunities, especially when native game species have become scarce. Since introduced species can become potential invaders, it is thus important to study their influence on habitat and native species (possible competition, transmission of pathogen, hybridization or habitat alteration). In this research, we will implement cutting edge research methodology in different fields (genetics, genomics, biochemistry, bioinformatics, GPS tracking and parasitology) and combine them to draw a detailed picture of translocation history for three ungulate species. Aoudad and European mouflon are introduced species in Mediterranean Europe, while wild boar recently established new populations on some islands through natural colonization or illegal translocations for hunting purposes. By integrating information on neutral and fitness-related traits, we will develop a protocol which will provide a comprehensive way to assess the status of non native populations and possible influence of hunting related activities to their expansion. Such approach will constitute the starting point for additional researches targeting selection processes in transformed landscapes and behavioral changes in populations facing alterations to their habitat. All these aspects are fundamental to understand how wild, but also domestic, species will adapt to changes in their environment, an aspect of increasing importance considering the alteration of natural conditions due to climate change.]]></summary_en></project><project>
<id>12461</id><title_hr><![CDATA[Međudjelovanje morskog (mikro)plastičnog otpada i metala zagađivala: mogući put od morskog okoliša do čovjeka]]></title_hr><title_en><![CDATA[]]></title_en><user_id>120</user_id><user_firstLast_name>Vlado Cuculić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-2765</code><acronim><![CDATA[METALPATH]]></acronim><duration>05.10.2021 - 05.10.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Interdisciplinarne prirodne znanosti, </scie_field_hr><scie_field_en>Interdisciplinary natural sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>865067</team_members_id><team_members_names><![CDATA[ Doktorand: Ana Rapljenović ]]></team_members_names><keywords_hr><![CDATA[morski (mikro)plastični otpad, metali u tragovima, morski okoliš, istočno Jadransko more, sediment, morska voda]]></keywords_hr><keywords_en><![CDATA[marine (micro)plastic litter, trace metals, marine environment, Eastern Adriatic Sea, sediment, seawater]]></keywords_en><summary_hr><![CDATA[Projekt je usmjeren k istraživanju međudjelovanja morskog plastičnog otpada i metala u tragovima (MT), posebice prioritetnih zagađivala Hg, Cd, Pb i Cu u obalnim područjima. S godišnjom proizvodnjom od 350 megatona (u rastu), plastika je jedan od glavnih onečišćivača te ima dugo vrijeme raspada i zbog toga se koncentrira u morima, dok Jadran postaje jedno od najzagađenijih mora plastikom. Druga potencijalno opasna komponenta u moru su MT koji predstavljaju značajnu prijetnju ljudskom zdravlju i morskim organizmima. Međudjelovanje morskog plastičnog otpada i MT može rezultirati njihovom prekoncentracijom/akumulacijom te stoga postati prijetnja za različite ekosustave.Interdisciplinarna istraživanja temelje se na suradnji širokog spektra znanstvenika i stručnjaka iz područja oceanologije, analitičke kemije, kemije polimera, geologije, biologije te ekološkog modeliranja. Specifični ciljevi su: analiza svojstava polimera te mikroplastike iz morskog okoliša; istraživanje adsorpcije MT na mikroplastiku; ispitivanje raspodjele koncentracija MT u morskoj vodi, sedimentu, mikroplastici i u morskim organizmima kao mogućoj direktnoj i/ili indirektnoj prijetnji čovjeku te procesa koji kontroliraju biogeokemijsko kruženje MT među njima; istraživanje učinka organske tvari, kao i pojedinih zajednica morskih mikroorganizama (mikrobiom) iz sedimenta na međudjelovanje MT i mikroplastike. Koristit ćemo najnovije elektrokemijske i spektrometrijske tehnike. Dobivene rezultate ćemo upotrijebiti za razvijanje ekološkog modela međudjelovanja MT i mikroplastike, za predviđanje njihova utjecaja na obalne ekosustave i pronalaženje optimalnih metoda za smanjivanje te prijetnje.Specifični ciljevi su odabrani s motivom da krajnji rezultat projekta bude koristan ne samo široj znanstvenoj zajednici, nego i krajnjim korisnicima kao što su lokalna i državna tijela koja upravljaju obalnim područjima. Nova saznanja mogu biti temelj boljoj procjeni rizika u svrhu unaprjeđenja kakvoće okoliša.]]></summary_hr><summary_en><![CDATA[Project will study marine plastic litter and trace metals (TM) interaction, especially primary pollutants Hg, Cd, Pb and Cu in the coastal areas. With annual production of 350 megatons (and rising), plastics have been recognized as one of the main pollutants, long-living, slowly decomposing and accumulating in oceans, while Adriatic becomes one of the most polluted seas regarding plastic litter. Another hazardous component in ocean are TMs that pose a substantial threat for the human health and marine biota. Once TM interact with marine plastic litter, hence concentrate/accumulate, it could become threat for the various coastal ecosystems.Interdisciplinary research involves wide spectrum of scientists and experts in the fields of oceanology, analytical chemistry, polymer chemistry, geology, biology and ecological modelling. Specific objectives are: characteristics assessment of polymer, and microplastics from marine environment; studying TM adsorption on unused polymers and on environmental microplastics; analysing TM distribution in coastal waters, sediments, microplastics and marine organisms as a possible direct and/or indirect threat to human, as well as the processes that govern TM biogeochemical cycles among them; study the effects of organic matter as well as specific marine microorganism communities (microbiome) from sediment on TM interaction with microplastics. We will use the most recent approaches utilizing electrochemical and spectrometric techniques. Results will enable us to develop an ecological model of TM-microplastics interactions, to predict TM-microplastic impact on coastal ecosystems and to find optimal method in weakening its threat.The specific objectives are selected to enable the outcome of the project be valuable not only to the broad scientific community, but also to end-users such as authorities that manage coastal zones. New findings can be the basis for a better risk assessment in order to improve the environmental quality.]]></summary_en></project><project>
<id>12462</id><title_hr><![CDATA[Predplanirana i reaktivna agilnost; razvoj i validacija specifičnih metoda mjerenja, utvrđivanje faktora utjecaja i učinkovitost transformacijskih postupaka]]></title_hr><title_en><![CDATA[]]></title_en><user_id>147</user_id><user_firstLast_name>Damir Sekulić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-5442</code><acronim><![CDATA[RAGCODS]]></acronim><duration>01.10.2021 - 30.09.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Kineziologija, </scie_field_hr><scie_field_en>Kinesiology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Kineziološki fakultet]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Kinesiology]]></institution_en><team_members_id>865149</team_members_id><team_members_names><![CDATA[ Doktorand: Vladimir Pavlinović ]]></team_members_names><keywords_hr><![CDATA[testovi, prediktori, povezanost, utjecaj, agilnost otvorene vještine, agilnost zatvorene vještine]]></keywords_hr><keywords_en><![CDATA[tests, predictors, associations, influence, open skill agility, closed skill agility]]></keywords_en><summary_hr><![CDATA[Poznata je važnost agilnosti u sportu, ali je u skorije vrijeme prepoznata njena važnost i izvan natjecateljskog sporta. Utvrđeno je postojanje dva manifestacijska oblika agilnosti: pred-planirane agilnosti (CODS) i reaktivne agilnosti (RAG). Ciljevi projekta su: (i) razviti testove za mjerenje RAG i CODS, (ii) utvrditi faktore utjecaja na RAG i CODS, (iii) provjeriti učinkovitost transformacijskih programa (treninga) u razvoju RAG i CODS; za sportaše i kliničku populaciju. Uzorak ispitanika činiti će sportaši i klinička populacija (svi stariji od 18 godina). Skupinu sportaša činiti će podskupine: rukometaši (n = 60; 50% žena), košarkaši (n = 60; 50% žena), vaterpolisti (n = 60; 50% žena) i igrači fustala (n = 60; 50% žena). Kliničku populaciju činiti će osobe starije od 50 godina koje će se nalaziti na postoperativnom tretmanu nakon operativnog zahvata zamjena zgloba ili artroskopske operacije koljena (n=100; 50% žena). Zavisne varijable biti će novokonstruirani testovi RAG i CODS. Nezavisne varijable biti će antropometrijske mjere i mjere sastava tijela (za sve skupine), mjere brzine, sile, eksplozivne snage i reaktivne snage (za sportaše). Najprije će se razviti i validirati testovi RAG i CODS temeljeni na bežičnim tehnologijama. Potom će se utvrditi povezanost nezavisnih i zavisnih varijabli. Konačno, provjeriti će se efikasnost specifičnih treninga u razvoju RAG i CODS. Metode obrade rezultata uključivati će procjenu metrijskih karakteristika testova, univarijatne i multivarijatne analize povezanosti nezavisnih i zavisnih varijabli, te analize za procjenu učinkovitosti treninga. Radit će se o jednom od prvih istraživanja u svijetu u kojem će se razviti testovi za mjerenje RAG i CODS u različitim sportovima, koje će sistematski istražiti problem RAG i CODS kod analizirane kliničke populacije, te koje će istražiti učinkovitost treninga RAG i CODS. Projekt će imati izravnu primjenu u sportskom treningu i postoperativnoj rehabilitacijskoj praksi.]]></summary_hr><summary_en><![CDATA[The importance of agility in sport is well known, and since recently the significance of this quality is recognized in non-athletic population. Two facets of agility are recognized, differentiating reactive agility (RAG), and change of direction speed (CODS). The aims of this project are: (i) to develop RAG and CODS tests, (ii) to identify predictors of RAG and CODS, (iii) to define efficacy of training aimed at development of RAG and CODS; in athletic- and non-athletic (clinical) participants. The sample will comprise athletes, and clinical sample. The athletes will be involved in handball (n = 60; 50% females), basketball (n = 60; 50% females), water polo (n = 60; 50% females), and futsal (n = 60; 50% females), Clinical sample will comprise 100 participants (50% females, > 50 years) patients at postoperative treatment after joint replacement or arthroscopic knee surgery. The developed tests of RAG and CODS will be observed as dependent variables (DV). The independent (IV) variables will comprise anthropometric/body composition indices (for all participants), sprinting-, power-, force-, and reactive-strength-capacites (for athletes). First, tests of RAG and CODS will be evaluated for reliability and validity. Next, relationships between IV and DV will be established. Finally, the efficacy of the training aimed at improvement of RAG and CODS will be evaluated. Statistics will include analyses aimed at evaluation of (i) reliability and validity of tests, (ii) relationships among variables, and (iii) evaluation of training effects. This investigation will be one of the first which will systematically develop and validate RAG and CODS tests in different sports and clinical population, and probably the first one where the problem of development of RAG and CODS will be systematically investigated. The findings will have direct implications in sports training, as well as in postoperative rehabilitation of an investigated clinical sample.  ]]></summary_en></project><project>
<id>12464</id><title_hr><![CDATA[Biougljen kao ekološki prihvatljiv i održiv način upravljanja ishranom vinove loze u kontekstu klimatskih promjena]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3037</user_id><user_firstLast_name>Igor Palčić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-9291</code><acronim><![CDATA[BIONUTRIVINE]]></acronim><duration>06.09.2021 - 23.12.2026</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Institut za poljoprivredu i turizam]]></institution_hr><institution_en><![CDATA[Institute of Agriculture and Tourism in Poreč]]></institution_en><team_members_id>865077</team_members_id><team_members_names><![CDATA[ Doktorand: Melissa Prelac ]]></team_members_names><keywords_hr><![CDATA[biougljen, GHG emisije, hraniva, klimatske promjene, vinova loza]]></keywords_hr><keywords_en><![CDATA[biochar, climate change, GHG emissions, grapevine, nutrients]]></keywords_en><summary_hr><![CDATA[Konvencionalno vinogradarstvo može dovesti do degradacije tala u smislu gubitka organske tvari tla, zbijanja tla i smanjene infiltracije vode, smanjenja sadržaja hraniva i akumulacije teških metala. S druge strane, znanstveni dokazi ukazuju da klimatske promjene predstavljaju dominantan izazov za vinogradarstvo u nadolazećim desetljećima, budući da emisije stakleničkih plinova, temperatura, oborine i drugi čimbenici mogu izravno utjecati na ekosustave. Predloženo istraživanje ima za cilj integrirati alate za ublažavanje ova dva vrlo aktualna problema globalnog vinogradarstva - klimatske promjene i degradaciju tla, koristeći koncept kružne ekonomije i valorizacije otpada, putem korištenja ostataka rezidbe vinove loze i njihovu transformaciju u biougljen. Cilj predloženog istraživanja je postići: moguće smanjenje emisije stakleničkih plinova u vinogradima; ublažavanje stresa od suše poboljšanjem kapaciteta tla za vodu; i održivo upravljanje ishranom vinove loze vraćanjem hraniva koja bi se inače nepovratno iznijela tijekom rezidbe. Nadalje, prema dostupnoj literaturi,  ovo će biti prvi eksperiment dugotrajne primjene biougljena u vinogradarskim tlima koje će istražiti i utjecaj na kvalitetu vina. Glavni elementi predloženog projekta su: a) prikupljanje i karakterizacija ostataka rezidbe vinove loze; b) laboratorijska proizvodnja i karakterizacija biougljena iz ostataka ostataka rezidbe (PRDB); c) proizvodnja i karakterizacija većih količina PRDB-a za primjenu u vinograd; d) stacionarni pokus u vinogradu (pet tretmana - PRDB, PRDB obogaćen UREA-om, ostaci rezidbe, gnojivo i kontrola; tri vegetacije će biti obrađene projektom, ali eksperiment će se nastaviti i nakon završetka projekta); e) eksperiment s folijarnim tretmanima (s ciljem razvoja novog proizvoda). Rezultati projekta bit će od praktične važnosti za poljoprivredni i vinogradarski sektor te obećavajući alat za ekološki prihvatljivo i održivo upravljanje ishranom vinove loze i ublažavanje klimatskih promjena.]]></summary_hr><summary_en><![CDATA[Conventional viticulture can lead to the degradation of soils in terms of soil organic matter loss, compaction and reduced water infiltration, reduction of nutrient content and heavy metal accumulation. On the other hand, scientific evidence sharply states that climate change represents a dominant challenge for viticulture in the upcoming decades, since GHG emission, temperature, precipitation, and other factors can directly impact ecosystems. The proposed research aims to integrate the tools for possible mitigation of this two present problems for global viticulture – climate change and soil degradation, using the concept of circular and zero-waste economy, via the valorization and utilization of grapevine pruning residues by their transformation into biochar. The proposed research aims to achieve: the possible reduction of vineyard GHG emissions; alleviation of drought stress by improving soil water holding capacity; and sustainable grapevine nutrient management by giving back the nutrients which will be otherwise lost during pruning. Furthermore, to our knowledge it will be the first experiment on biochar long-term vineyard soil application researching also the effect on wine quality. The main elements of the proposed project are: a) grapevine pruning residues collection and characterization; b) pruning-residues-derived biochar (PRDB) laboratory production and characterization; c) PRDB field-scale production and characterization; d) vineyard long-term experiment (five treatments – PRDB, PRDB enriched with UREA, pruning residues, fertilizer and control; three growing seasons are part of the project, but the experiment will continue after the end of the project); e) foliar treatments experiment (with the aim to develop a new product). The outcomes of the project will be of practical importance to the agricultural and viticultural sector and a promising tool towards environment-friendly and sustainable grapevine nutrient management and climate change mitigation.]]></summary_en></project><project>
<id>12466</id><title_hr><![CDATA[Metalni kompoziti za ultra-tanke infracrvene slojeve]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1019</user_id><user_firstLast_name>Vesna Janicki</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-7236</code><acronim><![CDATA[METACUC]]></acronim><duration>06.10.2022 - 05.10.2026</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>865275</team_members_id><team_members_names><![CDATA[ Doktorand: Hrishikesh Kamble ]]></team_members_names><keywords_hr><![CDATA[metalni kompositi, tanke slojeve, optička svjostava, perkolacija, infracrveno, hybridne čestice]]></keywords_hr><keywords_en><![CDATA[metal composites, thin films, optical properties, percolation, infrared, hybrid particles]]></keywords_en><summary_hr><![CDATA[Materijali s velikim gubicima, tj. s velikom ali konačnom vodljivošću, stvaraju složene pomake faze svjetla nakon refleksije. Zbog toga se mogu pojaviti jake interferencije u ultratankim filmovima, što je nedavno iskorišteno za dizajniranje apsorbera, sistema koji daju strukturalne boje i fotonaponskih sustava za vidljivo područje. Ako bi se primijenio u infracrvenom području, ovaj pristup bi mogao bitno transformirati tehnologiju slojeva, gdje je proizvodnja u konačnici ograničena minimalnom potrebnom debljinom. Međutim, materijali s visokim gubitkom u infracrvenom dijelu spektra su rijetki, budući da metali, koji imaju velike gubitke u vidljivom području, djeluju kao gotovo savršeni vodiči na većim valnim duljinama.Cilj ovog projekta je istražiti metalne kompozite kao materijale s velikim gubicima za ultra tanke infracrvene višeslojne sustave. Istraživanje će se fokusirati na: i) legurama metala, ii) slojevima hibridnih metalnih otočića i iii) metalnim slojevima u blizini praga perkolacije. Ovi sustavi potencijlano mogu pružiti znatno veće optičke gubitke od čistih metala radi svoje neuređenosti, prigušivanja na međupovršinama i elektromagnetske sprege među česticama. Prvi cilj projekta je unaprijediti temeljno razumijevanje ovakvih povećanih gubitaka pomoću teorijskih pristupa (ab-initio izračuna, elektrodinamičke simulacije i modeliranja tranzicije perkolacije i optičkih svojstava). Teorijski rad bit će potvrđen kombinacijom različitih eksperimentalnih pristupa izradi i modifikaciji uzoraka (nanošenje tankih slojeva, galvanska zamjena i žarenje) i tehnika karakterizacije. U drugoj fazi, stečeno znanje će se koristiti za izradu novih infracrvenih slojeva s naglaskom na temperaturnim prekidačima i ultratankim interferencijskim sustavima. Osim temeljne vrijednosti, potencijal teme projekta u primjeni ojačat će domaću instituciju kao budućeg partnera industriji. Projekt će mladim istraživačima omogućiti razvoj konkurentnih znanstvenih karijera u Hrvatskoj.]]></summary_hr><summary_en><![CDATA[It has been shown that highly lossy materials, i.e. with large but finite conductivity, generate complex phase shifts of light upon reflection. As a result strong interference can take place in ultrathin films, what has been recently exploited to design absorbers, structural coloration devices and photovoltaic systems for the visible range. If applied to infrared range, this approach could deeply transform coating technology, where fabrication is ultimately limited by the minimal required layers thickness. However, highly lossy materials are scarce in the infrared, since metals, that have large losses in the visible range, act as nearly perfect conductors in the infrared.The project aims to investigate metal composites as highly lossy materials for ultrathin infrared coatings. The research will focus on: i) metal alloys, ii) hybrid metallic island films and iii) nearly-percolated metal films. These systems can potentially provide significantly larger optical losses than pure metals due to disorder, interface damping and inter-particle coupling. The first project goal is to advance in fundamental understanding of these enhanced losses by means of several theoretical approaches (ab-initio calculations, electrodynamics simulations and modeling of percolation transition and optical properties). The theoretical work will be validated by combination of different approaches for sample fabrication and modification (thin film deposition, galvanic replacement and annealing treatments) and characterization techniques. In a second phase, the acquired knowledge will be used to devise novel infrared coatings, particularly temperature switches and ultrathin interference systems. In addition to fundamental value, the application potential of the project topic will reinforce the host institution for future industrially-oriented partnership. Finally, the project will provide opportunities to young investigators for developing a competitive research career in Croatia.]]></summary_en></project><project>
<id>12467</id><title_hr><![CDATA[Unapređenje usluga šumskih ekosustava Hrvatske kroz vrednovanje bioraznolikosti gljiva temeljenoj na DNA barkodiranju]]></title_hr><title_en><![CDATA[]]></title_en><user_id>19224</user_id><user_firstLast_name>Armin Mešić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-4010</code><acronim><![CDATA[ForFungiDNA]]></acronim><duration>13.12.2021 - 12.06.2026</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>865066</team_members_id><team_members_names><![CDATA[ Doktorand: Lucia Pole ]]></team_members_names><keywords_hr><![CDATA[šumarstvo, usluge šumskih ekosustava, gljive, bioraznolikost, DNA barkodiranje, integrativna taksonomija, biogeografija, fitopatologija]]></keywords_hr><keywords_en><![CDATA[forestry, forest ecosystem services, fungi, biodiversity, DNA barcoding, integrative taxonomy, biogeography, phytopathology]]></keywords_en><summary_hr><![CDATA[Usluge ekosustava su ekološke značajke, funkcije ili procesi ekosustava koji imaju utjecaj na ljudsko blagostanje. Očuvanje cjelokupne biološke raznolikosti u šumama ima izrazito pozitivan utjecaj na unapređivanje usluga šumskih ekosustava. U ukupnoj kopnenoj površini Republike Hrvatske šume zauzimaju oko 37%. Zbog položaja na razmeđi kontinentalne, sredozemne, panonske i alpske biogeografske regije, Hrvatska se u europskim okvirima ističe vrlo velikom bioraznolikošću. Šume su najsloženiji kopneni ekosustavi i najznačajniji tip staništa za gljive u kojem živi najveći broj gljivljih vrsta. Gljive u šumskim staništima imaju ključne ekološke uloge i nužne su za zdravlje i opstanak šuma. Ljudski utjecaj koji se ogleda u često prekomjernom iskorištavanju prirodnih resursa i položaj u jednom od svjetskih žarišta klimatskih promjena čine biološku raznolikost u hrvatskim šumama vrlo ugroženom. Gljive su u Hrvatskoj daleko najslabije istražena skupina organizama, pri čemu je do danas poznato tek oko 23% od ukupno procijenjenog broja vrsta. Glavni cilj projekta je istražiti bioraznolikost gljiva u šumama Hrvatske uz pomoć metoda DNA barkodiranja, te analizirati njen utjecaj na usluge šumskih ekosustava. Važan rezultat projekta biti će nadopunjavanje bioinformatičkih međunarodnih baza podataka DNA sekvencama gljivljih vrsta koje do danas u tim bazama nisu zastupljene. Sve vrste za koje su u ovom projektu dobiveni DNA barkodovi kategorizirat će se u trofičke skupine (patogene, mikorizne i saprotrofne vrste) i procijenit će se status ugroženosti tih vrsta u Hrvatskoj. Rezultati projekta imat će veliki potencijal primjene u šumarstvu, prehrambenoj industriji, farmaciji te zaštiti prirode. Podaci o DNA barkodovima vrsta gljiva posebno će biti značajni u šumarstvu za relativno brzu i preciznu identifikaciju, kontrolu i suzbijanje patogena drveća, ali i za identifikaciju mikoriznih i saprotrofnih vrsta.]]></summary_hr><summary_en><![CDATA[Ecosystem services are the ecological characteristics, functions, or ecosystem processes that contribute to human wellbeing. Conservation of the overall biodiversity in the forests has strong positive effect on the enhancement of forest ecosystem services. About 37% of the total land area of the Republic of Croatia is covered by forests. Croatia is distinguished by the great biodiversity due to its position on the dividing line between Continental, Mediterranean, Pannonian and Alpine biogeographical regions. Forests are the most complex terrestrial ecosystems and the most important habitat for fungi. Fungi play key ecological roles in the forests and are necessary for the forest health and existence. Human over-exploitation of natural resources and the geographical position of Croatia in the climate change hot-spot area, make biodiversity of its forests highly endangered. Fungi are the far least studied group of organisms in Croatia with only 23% of species recorded so far out of the total estimated number. The main project aim is to study fungal biodiversity of Croatian forests through the DNA barcoding methods and to analyze its impact on forest ecosystem services. The project will result in the addition of fungal DNA sequences to international bioinformatic databases for a number of species that are not represented in these bases to date. All DNA barcoded species in this project will be categorised in trophic groups (pathogens, saprotrophs, and mycorrhizal species) and the intensity of their impact on the forest ecosystem services will be assessed. The project results will have great potential for different applications in forestry, food industry, pharmacy and nature conservation. Application of DNA fungal barcodes will be especially important in forestry for relatively fast and accurate identification, control, and suppression of plant pathogens, as well as for identification of mycorrhizal and saprotrophic species.]]></summary_en></project><project>
<id>12468</id><title_hr><![CDATA[Bilinogojstvom do sekundarnih biljnih metabolita: primjena mineralnih hraniva i elicitora za povećanje koncentracije fenola u listu masline]]></title_hr><title_en><![CDATA[]]></title_en><user_id>12403</user_id><user_firstLast_name>Igor Pasković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-5517</code><acronim><![CDATA[PhytoFarmOL]]></acronim><duration>01.09.2021 - 02.06.2026</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Institut za poljoprivredu i turizam]]></institution_hr><institution_en><![CDATA[Institute of Agriculture and Tourism in Poreč]]></institution_en><team_members_id>865042</team_members_id><team_members_names><![CDATA[ Doktorand: Marija Polić Pasković ]]></team_members_names><keywords_hr><![CDATA[ishrana bilja, list masline, oleuropein, paunovo oko, oralno zdravlje]]></keywords_hr><keywords_en><![CDATA[plant nutrition, olive leaf, oleuropein, olive leaf spot, oral health]]></keywords_en><summary_hr><![CDATA[Fenolni spojevi oleuropein i hidroksitirosol smatraju se glavnim aktivnim spojevima lista masline za koje je dokazano antikancerogeno, protuupalno i antimikrobno djelovanje. Oleuropein i hidroksitirosol, ali i ostali fenoli, imaju specifičnu ulogu u zaštiti bilja i povećanju otpornosti na fitopatogene gljive što može biti od presudne važnosti za održivi uzgoj maslina općenito. Fenoli i polifenoli su sveprisutni spojevi u biljkama koji igraju važnu ulogu u obrambenom mehanizmu biljke domaćina u odnosu na filamentozne gljive. Važnost fenola, pored povećanja otpornosti biljke na patogene, očituje se i u proizvodnji funkcionalne hrane i nutraceutika te lijekova na prirodnoj bazi za liječenje oralnih bolesti. Potreba za pronalaskom novih terapijskih postupaka u liječenju patoloških stanja usne šupljine dovela je do povećanog interesa za upotrebu prirodnih supstrata.Dokazano je da poljoprivredna praksa može povećati sadržaj fenola u listu masline. Samo je nekoliko istraživanja do sada bilo usmjereno na proučavanje utjecaja mineralne ishrane na sastav fenola u listu masline. U ovom projektu planira se provesti cijeli niz eksperimenata kako bi se utvrdio utjecaj određenih mineralnih hraniva (N, Ca, Mg, Mn, Zn, Cu i B) i elicitora (fosfit i kalijev silikat) na sastav fenola u listu masline kod različitih sorata. Također ocijenit će se i utjecaj prethodnog odabranog mineralnog hraniva ili elicitora, koji se pokaže kao najučinkovitiji u povećanju razine fenola, na razvoj bolesti paunovo oko koje uzrokuje fitopatogena gljiva Venturia oleaginea (sin. Spilocaea oleaginea). Razvoj bolesti pratit će se na tretiranim maslinama u polju ili kontroliranim uvjetima u plasteniku. Učinak najboljeg tretmana bit će ispitan kroz kvalitetu maslinovog ulja na sorti Leccino uzgajanoj na različitim terroirima. U okviru ovog projekta također se planiraju provesti predklinička i klinička istraživanja utjecaja ekstrakta lista masline na kandidijazu usne šupljine.]]></summary_hr><summary_en><![CDATA[Oleuropein and hydroxytyrosol are considered the main active olive compounds and their health benefits thought their anti-carcinogenic, anti-inflammatory, and antimicrobial proprieties has been proven. Nevertheless, oleuropein and hydroxytyrosol as well as total phenols, have specific role plant protection and resistance against fungal pathogens which may be of crucial importance for olive sustainable growing. It has been noticed that phenolic and polyphenolic compounds, as pre-formed antibiotic compounds, are ubiquitous in plants and play an important role in host plant’s pre-existing chemical defences against filamentous fungi. The phenolics in olive leaves, beside upgraded resistance to fungal pathogens, may have potential in the production of functional food and nutraceuticals. They could be easily used as oral remedies in the treatment of stomatognatic pathological conditions, where the need of finding new therapeutic procedures has led to increased interest in the use of natural substrates. There are evidence that agricultural practices can increase phenolics in olive leaves. Only a few studies have been focused on studying the effects of olive mineral nutrition on the olive leaves phenolic profile. In this project, series of experiments are planned to be conducted in order to determine the effect of selected mineral elements (N, Ca, Mg, Mn, Zn, Cu, and B) and elicitors (phosphite and potassium silicate) on leaf phenolic profile of olive cultivars. The effect of previously selected mineral/elicitor treatment as the best phenolic enhancer, on the development of olive leaf spot (Venturia oleaginea - syn. Spilocaea oleaginea), will be tested under greenhouse and field conditions. The impact of best phenolic enhancer will be tested thought quality of olive oil on Leccino cultivar grown at different terroirs. The preclinical and clinical studies investigating the effect of olive leaf extract on oral cavity candidiasis will be conducted during this project as well.]]></summary_en></project><project>
<id>12469</id><title_hr><![CDATA[Modulacija polifenolnog profila voća uslijed fizikalnih tretmana nakon branja]]></title_hr><title_en><![CDATA[]]></title_en><user_id>234</user_id><user_firstLast_name>Davor Kovačević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-6698</code><acronim><![CDATA[APPLPEMs]]></acronim><duration>10.11.2021 - 09.11.2025</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>29114</team_members_id><team_members_names><![CDATA[ Doktorand: Katarina Jerin ]]></team_members_names><keywords_hr><![CDATA[polielektroliti, višeslojevi, ionski efekti, prevlake, jabuke]]></keywords_hr><keywords_en><![CDATA[polielectrolytes, multilayers, ionic effects, coatings, apples]]></keywords_en><summary_hr><![CDATA[Polielektrolitni višeslojevi (eng. polyelectrolyte multilayers, PEM) su površinske prevlake koje nastaju naizmjeničnom adsorpcijom pozitivno i negativno nabijenih polielektrolita na čvrstu površinu. Uz fundamentalna istraživanja, posljednjih se godina polielektrolitni višeslojevi intenzivno istražuju i zbog njihove potencijalne primjene u industriji, medicini i biotehnologiji. Glavni su ciljevi predloženog projekta dodatno razjašnjenje mehanizama nastajanja i svojstava polielektrolitnih višeslojeva s posebnim naglaskom na utjecaje ionskih efekata na navedeni proces, te primjena dobivenih rezultata na istraživanje prevlaka za zaštitu svojstava jabuka. Glavna hipoteza projekta je da bolje razumijevanje ionskih utjecaja može dovesti do kreiranja polielektrolitnih višeslojeva unaprijeđenih svojstava što bi omogućilo pripravu učinkovitijih filmova. Upotreba različitih soli može dovesti do nastajanja polielektrolitnih višeslojeva s različitim hidratacijskim svojstvima, a poznato je da hidratacija utječe i na procese adhezije. S druge strane, soli mogu utjecati i na dinamiku lanca i posljedično samo-obnavljanje. Predloženi projekt sastoji se od tri međusobno povezana cilja: 1. Karakterizacija modelnih supstrata za formiranje polielektrolitnih višeslojeva, 2. Dizajn, priprava i karakterizacija polielektrolitnih višeslojeva i 3. Primjena polielektrolitnih višeslojeva kao prevlaka za zaštitu voća. Kod cilja 3) u svrhu optimiziranja primjene koristit će se rezultati ostvareni u cilju 1) i 2). Detaljna karakterizacija polielektrolitnih višeslojeva provest će se nizom naprednih komplementarnih metoda (npr. elipsometrija i AFM), a značajan uvid u svojstva jabuka prekrivenih polielektrolitnim višeslojevima bit će dobiven odgovarajućim mikroskopskim eksperimentima.]]></summary_hr><summary_en><![CDATA[Polyelectrolyte multilayers (PEMs) are surface coatings formed by alternating adsorption of positively and negatively charged polyelectrolytes on a solid surface. Additional to the fundamental research, polyelectrolyte multilayers have been intensively investigated in recent years due to their potential applications in industry, medicine and biotechnology. The main goals of the proposed project are further understanding of the mechanisms of formation and properties of polyelectrolyte multilayers with a special emphasis on the effects of ionic effects on the process, as well as the application of the obtained results to the research of the coatings that could be used for the protection of apples. The main hypothesis is that the better understanding of the ionic effects can lead to the creation of PEMs with better and adjustable properties that will then enable the formation of more efficient coatings. Using different salts might create PEMs having different hydration properties and hydration has been known to impact adhesion processes. On the other hand, salts can impact the chain dynamics and therefore self-healing.The proposed project consists of three interconnected: 1. Characterization of model substrates for formation of polyelectrolyte multilayers, 2. Design, preparation and characterization of polyelectrolyte multilayers and 3. Application of polyelectrolyte multilayers as apple coatings. In objective 3), in order to optimize possible applications, the results obtained in objectives 1) and 2) will be used. The detailed characterization of polyelectrolyte multilayers will be carried out through a series of advanced complementary methods (e.g. ellipsometry and AFM) and a significant insight into the properties of polyelectrolyte multilayer coated apples will be obtained by microscopic experiments.]]></summary_en></project><project>
<id>12470</id><title_hr><![CDATA[Biološka, kronološka i relativna dob u funkciji uspostave nacionalnog sustava detekcije i razvoja sportskih talenata ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>784</user_id><user_firstLast_name>Dražen Čular</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-8613</code><acronim><![CDATA[BKRD]]></acronim><duration>02.11.2021 - 31.10.2025</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Kineziologija, </scie_field_hr><scie_field_en>Kinesiology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Kineziološki fakultet]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Kinesiology]]></institution_en><team_members_id>865174</team_members_id><team_members_names><![CDATA[ Doktorand: Matej Babić ]]></team_members_names><keywords_hr><![CDATA[sport, biološka dob, relativna dob, koštana dob, detekcija, selekcija, talenti, sazrijevanje, starenje, DNA, glycani, vrhunac ubrzanog rasta sport, ]]></keywords_hr><keywords_en><![CDATA[bone age, detection, selection, talents, maturation, ageing, DNA, glycans, peak height velocity]]></keywords_en><summary_hr><![CDATA[Identifikacija talenata u sportu pretpostavlja prepoznavanje darovitih s ciljem maksimalnog ostvarenja njihovih potencijala, pri čemu se često zanemaruje biološka i relativna dob. Ciljevi projekta su: 1) Ojačati hrvatski potencijal razvoja sportskih talenata povezivanjem: nacionalnih saveza, trenera i znanstvenih institucija, 2) Istražiti povezanost biološke i relativne dobi sa postignutim rezultatima, 3) Generirati nova znanja u području biološke dobi i kontraktilnih svojstava skeletnih mišića, 4) Ojačati svijest o važnosti biološke dobi u procesu razvoja sportskih talenata. Na uzorku (n=>480) sportaša registriranih pri nacionalnim savezima (n=5), prikupit će se podaci o: spolu, kronološkoj/biološkoj/relativnoj dobi, postignutim rezultatima, zdravstvenom i reprezentativnom statusu. Relativna dob će se temeljiti na datumima rođenja. Procjena biološke dobi provest će se: a) metodom procjene somatske zrelosti, b) analizom glikozilacije IgG-a koja se mijenja s dobi i c) metodom procjene koštane zrelosti snimanjem šake ispitanika. Kontraktibilna svojstva skeletnih mišića analizirat će se primjenom neinvazivne TMG metode. Istražit će se upotrebna vrijednost primijenjenih metoda na uzorku ispitanika podijeljenih na tri subuzorka: a) usporen , b) normalan i c) ubrzan razvoj. Primjenom HI kvadrat testa ispitat će se značajnost razlika u proporcijama zastupljenosti uspješnih, odnosno neuspješnih sportaša. Doprinos prediktora uspješnosti u pojedinom sportu ispitivat će se primjenom naprednih regresijskih modela. Realizacija projektnih aktivnosti rezultirat će: a) provjerom postojanja RAE efekta, b) provjerom upotrebne vrijednosti primijenjenih metoda procjene biološke dobi i kontraktilnih svojstava skeletnih mišića. Za očekivati je da primjena rezultata u praksi doprinese smanjenju pogrešaka u selekciji, smanjenju odustajanja od sporta i uspostavi nacionalnog sport talent sustava.]]></summary_hr><summary_en><![CDATA[Sports talent identification implies identification of the gifted, so as to achieve their fullest potential, often neglecting biological and relative age. Project objectives are: 1) To strengthen Croatian potential of sports talent development by connecting: national federations, local community, coaches and scientific institutions; 2) To investigate the correlation of biological and relative age with results; 3) To generate new knowledge on the usefulness of the instrument for assessing biological age and muscle contractile; 4) To strengthen awareness on the importance of biological age in the process of sports talent development. On a sample of athletes (n=>480), registered by national federations (n=5), data on gender, achieved results, training, representative and health status will be collected. Relative age will be based on date of birth. Biological age will be assessed by: a) somatic maturity assessment method, b) analysis of IgG glycosylation, which changes with age, and c) by method of assessing skeletal maturity of subjects’ left hand. Muscle contractile properties will be analysed by TMG method. The usefulness of the applied methods will be analysed on a sample of Croatian athletes divided into three subsamples: a) delayed, b) average and  c) advanced growth. the Chi-Square Test will be used to test the significance of differences in the proportions of successful and less successful athletes. Contribution of different predictors of success will be assessed by employing advanced statistical regression models. Project activities should result in: a) testing the existence of the RAE effect, b) testing the usefulness of the applied instruments on a sample of young Croatian athletes. It is to be expected that the application of the Project results in practice will contribute to: reduction of wrong selection, reduction of the level of sport drop-outs, establishment of the Croatian national sports talent system.]]></summary_en></project><project>
<id>12471</id><title_hr><![CDATA[Roles od ADAR proteins in herpes simplex virus 1 infection]]></title_hr><title_en><![CDATA[]]></title_en><user_id>43</user_id><user_firstLast_name>Igor Jurak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-9152</code><acronim><![CDATA[]]></acronim><duration>01.01.2022 - 31.12.2025</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Interdisciplinarno područje znanosti</scie_area_hr><scie_area_en>Interdisciplinary scientific area</scie_area_en><scie_field_hr>Biotehnologija u biomedicini, </scie_field_hr><scie_field_en>Biotechnology in Biomedicine, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Fakultet biotehnologije i razvoja lijekova]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Biotechnology and Drug Development]]></institution_en><team_members_id>865076</team_members_id><team_members_names><![CDATA[ Doktorand: Adwait Anand Parchure ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>12472</id><title_hr><![CDATA[Okolišni čimbenici i mikrobiološke interakcije u strukturi dentalnog biofilma (DENTALBIOFILM HRZZ IP-2020-02-4027)]]></title_hr><title_en><![CDATA[]]></title_en><user_id>77</user_id><user_firstLast_name>Stjepan Špalj</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-6438</code><acronim><![CDATA[]]></acronim><duration>01.02.2023 - 01.04.2026</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Dentalna medicina, </scie_field_hr><scie_field_en>Dental medicine, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Fakultet dentalne medicine]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Dental Medicine]]></institution_en><team_members_id>866626</team_members_id><team_members_names><![CDATA[ Doktorand: MATEA BADNJEVIĆ ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>12473</id><title_hr><![CDATA[Mikrobna ekologija jezerskih ekosutava - novi pristup ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>74</user_id><user_firstLast_name>Sandi  Orlić </user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-1935</code><acronim><![CDATA[MALENA]]></acronim><duration>14.10.2021 - 13.10.2025</duration><status>Prekinut</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>865079</team_members_id><team_members_names><![CDATA[ Doktorand: Ivana Stanić ]]></team_members_names><keywords_hr><![CDATA[bakterije, raznolikost, SSG, metanotrofi, klimatske promjene, jezera ]]></keywords_hr><keywords_en><![CDATA[bacteria, diversity, NGS, methanotrophs, climate changes, lakes ]]></keywords_en><summary_hr><![CDATA[Mikroorganizmi podržavaju kompleksne ekosustave održivim korištenjem sunčeve svjetlosti, vode, zraka i minerala kroz bezbrojne funkcije kao što su oksidacija i proizvodnja vodika, fiksacija CO2 i N2, metanogeneza i metanotrofija, fotosinteza i još mnogo toga. Nedavne globalne promjene sugeriraju da je Zemlja sada ušla u još jednu posebnu geološku eru, Antropocen, gdje neosporivo možemo identificirati dubok utjecaj ljudi na Zemlji, uključujući atmosferu, oceane i zemlju. Iako slatke vode čine samo oko 2,5% ukupnih vodenih masa Zemlje, jezera i drugi slatkovodni ekosustavi, osim što su glavni izvori pitke vode, neizmjerno su važni za globalni proračun ugljika i osjetljivi su pokazatelji globalnih i regionalnih promjena okoliša. Iako slatke vode čine oko 2,5% ukupne vode na Zemlji, jezera i druge unutarnje vode, osim što su glavni resursi pitke vode, nesrazmjerno su važni za globalni proračun ugljika i osjetljivi pokazatelj globalnih i regionalnih promjena u okolišu. Jezera emitiraju značajne količine stakleničkih plinova, posebno metana, stakleničkog plina koji je i dvadeset puta snažniji od ugljičnog dioksida. Procjenjuje se da ukupna emisija slatkovodnih stakleničkih plinova čini oko 22% ukupne globalne emisije metana i oko tri četvrtine svih prirodnih emisija. U Hrvatskoj su jezera vrlo ranjiva i izložena snažnom okolišnom i antropogenom utjecaju. Korištenjem najnovijih tehnologija u projektu MALENA želimo razumjeti značaj mikroba u kruženju metana u istraživanim jezerima. Rezultati ovog višefaznog projekta će dati značajne odgovore za funkcioniranje jezera kao i identifikaciju najznačajnijih igrača u kruženju metana. Konačno, cilj nam je formirati skupinu znanstvenika u mikrobnoj ekologiji globalnih promjena, jer očigledno da rješenja ekoloških problema i naše budućnosti zahtijevaju holistički pristup donošenju odluka, neosporno uključujući nova znanja o važnosti mikroorganizama.]]></summary_hr><summary_en><![CDATA[Microorganisms support complex ecosystems sustainably using sunlight, water, air and minerals through myriad functions as hydrogen oxidation and production, carbon dioxide and nitrogen fixation, methanogenesis and methanotrophy, photosynthesis and more. Recent global changes suggest that Earth has now entered another distinct geological era, the Anthropocene, where we can identify profound impact of humans on the Earth, including the atmosphere, oceans and land. Although freshwaters constitute only about 2,5% of the total Earth water, lakes and other inland waters, aside of being the principal drinking water resources are disproportionally important for the global carbon budget and sensitive indicators for global and regional environmental change. Lakes emit significant amounts of greenhouse gases, in particular methane, a greenhouse gas more that twenty times more potent than carbon dioxide. Total freshwater greenhouse gas emissions are estimated to make up around 22 % of total global methane emissions and around three quarters of all natural emissions. In Croatia, lakes are very vulnerable and subjected to strong environmental and anthropogenic influence. Using the state-of-the-art technologies in the MALENA project we want to understand the microbial significance in methane cycling in the investigated lakes. The results of this multiphasic project will give significant answers for the lake functioning as well the identification of the most significant players in the methane cycling. Finally, we aim to form a group of scientists in microbial ecology of global change, because evidently, solutions to environmental problems and our future require a holistic approach to decision taking, indisputably including knowledge of the role of microorganisms.]]></summary_en></project><project>
<id>12474</id><title_hr><![CDATA[Istraživanje provenijencije umjetnina u zagrebačkim zbirkama]]></title_hr><title_en><![CDATA[]]></title_en><user_id>402</user_id><user_firstLast_name>Ljerka Dulibić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-4028</code><acronim><![CDATA[ZagArtColl_ProResear]]></acronim><duration>01.04.2022 - 30.09.2026</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Povijest umjetnosti, </scie_field_hr><scie_field_en>Art history, </scie_field_en><institution_hr><![CDATA[Hrvatska akademija znanosti i umjetnosti]]></institution_hr><institution_en><![CDATA[Croatian Academy of Sciences and Arts]]></institution_en><team_members_id>865338</team_members_id><team_members_names><![CDATA[ Doktorand: Josip Klaić ]]></team_members_names><keywords_hr><![CDATA[umjetničke zbirke, Zagreb, provenijencija, Strossmayerova galerija starih majstora, transferi (vlasništva) umjetnina]]></keywords_hr><keywords_en><![CDATA[art collections, Zagreb, provenance research, Strossmayer Gallery of Old Masters, (ownership) transfers of artworks]]></keywords_en><summary_hr><![CDATA[U okviru predloženog projekta „Istraživanje provenijencije umjetnina u zagrebačkim zbirkama“ provest ćemo temeljito arhivsko istraživanje koje će biti čvrsto uporište za identifikaciju umjetnina i/ili zbirki u Zagrebu i praćenje njihove sudbine u slijedu promjena geopolitičkih okolnosti u različitim razdobljima hrvatske povijesti, posebice prije, tijekom i nakon II. svjetskog rata. Time će se omogućiti sagledavanje uloge različitih vlasti, institucija i pojedinaca u upravljanju umjetničkom baštinom. Umjetnine identificirane i/ili kontekstualizirane s aspekta provenijencije obradit će se i u okviru tradicionalnih povijesnoumjetničkih metoda, čime će se osigurati cjelovitost pristupa temi.Iako je Republika Hrvatska potpisnica međudržavnih dokumenata kojima se poziva na intenziviranje istraživanja podrijetla umjetnina, u Hrvatskoj istraživanje provenijencije još uvijek nije institucionalno podržano, a općenita svijest o potrebi utvrđivanja ranijih vlasnika umjetnina nije dovoljno razvijena niti u muzejima.Istraživanje sudbine umjetnina prije i tijekom poslijeratne muzealizacije izazovan je no nužan element u obuhvatnoj znanstvenoj i stručnoj obradi nacionalne nam kulturne baštine. Očekujemo značajan utjecaj na bolje razumijevanje uloge kulturne baštine u procesima društvenoga razvoja obilježenima (ne)razriješenim povijesnim konfliktima. Očekivani doprinos je i etabliranje različitih aspekata suvremene metodologije istraživanja provenijencije umjetnina u hrvatskoj povijesti umjetnosti.Transparentnost istraživačkih postupaka, čvrsto utemeljenih u arhivskim dokumentima i materijalnim tragovima vlasništva na umjetninama, osigurat će prijenos iskustava i metodologije ne samo povjesničarima umjetnosti već i muzejskim, arhivskim i djelatnicima srodnih struka, čime će se osigurati znatan utjecaj na etabliranje odgovornog i pouzdanog bavljenja ovom neistraženom i još uvijek &#39;osjetljivom&#39; temom u hrvatskim baštinskim ustanovama. ]]></summary_hr><summary_en><![CDATA[Within the project proposal Provenance Research on Artwork in Zagreb Collections, we will conduct an in-depth archival research which will provide a firm basis for identification of artworks and/or collections in Zagreb, as well as for tracking their destinies through a series of changes of geopolitical circumstances in different stages of Croatian history, especially before, during and after WWII. This will enable the assessment of the role of different regimes, institutions and individuals in management of artistic heritage. Artwork identified and/or contextualized from the aspect of their provenance will also be researched through the traditional art-historical methods, thus ensuring a comprehensive approach to the topic.Despite the fact that the Republic of Croatia is among the signatories of international agreements which encourage the intensification of provenance research, this type of research in Croatia is still lacking institutional support, and general awareness of the necessity of determining previous owners of artwork has not yet been sufficiently raised not even within the museum profession.The research of provenance of artwork before and after the post-war musealization is a challenging, but necessary element of comprehensive research of national cultural heritage. We anticipate a significant impact on understanding the role of cultural heritage in societal processes marked by (un)resolved historical conflicts. Expected impact of the research is also the introduction of contemporary methodology of provenance research into Croatian art history.The transparency of research, firmly grounded in the archival sources and material traces of ownership of artwork, will ensure the transfer of experiences and methodology not only to art historians, but also to other professionals, which will have a significant impact on establishing responsible and reliable engagement in this understudied and still “sensitive” topic in Croatian heritage institutions.]]></summary_en></project><project>
<id>12476</id><title_hr><![CDATA[Agrobioraznolikost – osnova za prilagodbu i ublažavanje posljedica klimatskih promjena u poljoprivredi]]></title_hr><title_en><![CDATA[]]></title_en><user_id>22828</user_id><user_firstLast_name>Nikola Major</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-5148</code><acronim><![CDATA[]]></acronim><duration>16.12.2021 - 15.12.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Prehrambena tehnologija, </scie_field_hr><scie_field_en>Food technology, </scie_field_en><institution_hr><![CDATA[Institut za poljoprivredu i turizam]]></institution_hr><institution_en><![CDATA[Institute of Agriculture and Tourism in Poreč]]></institution_en><team_members_id>865267</team_members_id><team_members_names><![CDATA[ Doktorand: Tvrtko Karlo Kovačević ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>12477</id><title_hr><![CDATA[Određivanje uloga akvaporina 3 i 5 u razvoju rezistencije tumora dojke na oksidacijski stres]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5615</user_id><user_firstLast_name>Ana Čipak Gašparović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-5397</code><acronim><![CDATA[AquaBCaRe]]></acronim><duration>08.10.2021 - 07.04.2026</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>865065</team_members_id><team_members_names><![CDATA[ Doktorand: Monika Mlinarić ]]></team_members_names><keywords_hr><![CDATA[akvaporin 3, akvaporin 5, Nrf2, FOXO, tumor dojke]]></keywords_hr><keywords_en><![CDATA[aquaporin 3, aquaporin 5, Nrf2, FOXO, breast cancer]]></keywords_en><summary_hr><![CDATA[Otkriće akvaporina, membranskih pora koje kanaliziraju ulaz vode u stanicu, promijenilo je percepciju o pasivnom ulasku vode. Ovi transmembranski proteinski kanali građeni su kao tetrameri, a kod sisavaca je poznato 13 izomera. Izomeri se, ovisno o primanoj strukturi i specifičnoj permeabilnosti, dijele u tri skupine: na ortodoksne, koji primarno služe za transport vode, akvagliceroporine za transport glicerola i neortodoksne akvaporine, koji su isključivo na organelima. Uz vodu i glicerol, akvaporini provode i druge male nenabijene molekule kao što su: H2O2, urea, NO i CO2. Mogućnost provođenja navedenih molekula u stanicu objašnjava i funkcije akvaporina: održavanje ravnoteže vode u tkivima, migracija, proliferacija i adhezija stanica, čime neizbježno imaju ulogu u razvoju tumora. Kod tumora dojke, AQP3 se lokalizira uz NOX2 protein koji katalizira stvaranje H2O2 koji zatim AQP3 unosi u stanicu. U stanici, H2O2 modificira signalne puteve i potiče proliferaciju, dok je kod stanica s izraženim EGFR (locira se u lipidnim splavima membrane) neophodan za provođenje signala EGF-EGFR kaskadom. Istraživanja pokazuju povezanost akvaporina i signalnih puteva proliferacije, poput PI3K/Akt, u raznim humanim tumorima. Do sada nije istraženo kako H2O2 unesen akvaporinima regulira antioksidacijski sustav stanice. Pokazali smo da su AQP3 i AQP5 vezani uz NRF2 antioksidacijski transkripcijski faktor stoga ovaj projekt cilja razjasniti mehanizam kojim se ostvaruje ova korelacija. Regulacija unutarstaničnog oksidacijskog stresa akvaporinima bitan je u razvoju tumora s obzirom da izlaganje oksidacijskom stresu može potaknuti adaptaciju na stres, odnosno rezistenciju tumora na konvencionalne kemoterapeutike koji su bazirani na prekomjernom oksidacijskom stresu. Pojašnjavanje mehanizama djelovanja ova dva, za sada nepovezana sustava može poboljšati naše razumijevanje razvoja rezistencije tumora te otvoriti nove mogućnosti adjuvantne terapije tumora s boljim ishodom same terapije.]]></summary_hr><summary_en><![CDATA[Discovery of aquaporins, membrane pore which mediate water transport, changed our perception of passive water intake. In mammals, there are 13 isoforms of these tetrameric transmembrane channels. Isomers are grouped regarding their primary structure and specific permeability into three groups: orthodox, utilizing water transport, aquaglyceroporins, mediating glycerol transport and non-orthodox, localized specifically on organelle membranes. In addition to water and glycerol, aquaporins also channel other small, uncharged molecules such as H2O2, urea, NO and CO2. Transport of these molecules can contribute to understanding aquaporin functions: tissue water balance, migration, proliferation and adhesion. These functions inevitably link aquaporins to cancer. In breast cancer, AQP3 localizes by NOX2 which produces H2O2. This H2O2 is then channelled by AQP3 into the cell where it interacts with signalling pathways and stimulates proliferation. In EF receptor expressing cells (EGFR is located in lipid rafts) H2O2 is needed for the EGF-EGFR cascade. Studies show link between aquaporins and certain signalling pathways such as PI3K/Akt in different tumors. Interestingly, there is no dana on the link between aquaporin expression and antioxidative defence. We have previously shown that AQP3 and AQP5 are linked to NRF2 transcription factor, therefore in this project our aim is to clarify the mechanism of this relation. Regulation of intracellular oxidative stress by aquaporins is important in tumor development as oxidative stress cause adaptation to stress further leading to resistance to conventional tumor therapy. Revealing the mechanism oh these two systems can improve our knowledge of the tumor resistance and opens possibility of new adjuvant therapy with better outcome.]]></summary_en></project><project>
<id>12480</id><title_hr><![CDATA[(Novi) etički i društveni izazovi digitalnih tehnologija u domeni zdravstvene skrbi]]></title_hr><title_en><![CDATA[]]></title_en><user_id>23203</user_id><user_firstLast_name>Anto Čartolovni</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-9366</code><acronim><![CDATA[Digit-HeaL]]></acronim><duration>02.11.2021 - 02.05.2026</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filozofija, </scie_field_hr><scie_field_en>Philosophy, </scie_field_en><institution_hr><![CDATA[Hrvatsko katoličko sveučilište, Zagreb]]></institution_hr><institution_en><![CDATA[Catholic University of Croatia]]></institution_en><team_members_id>865136</team_members_id><team_members_names><![CDATA[ Doktorand: Luka Poslon ]]></team_members_names><keywords_hr><![CDATA[Digitalne tehnologije, Digitalno zdravlje, Bioetika, Umjetna inteligencija, Veliki podaci]]></keywords_hr><keywords_en><![CDATA[Digital technologies, Digital Health, Bioethics, Artificial intelligence, Big data]]></keywords_en><summary_hr><![CDATA[Zdravstvena skrb više nego ikad pogođena je različitim faktorima primjerice, manjkom obrazovane radne snage i kompleksnošću bolesti što zahtijeva određenu racionalizaciju i efikasnost. Kako bi učinkovito vodila prema povećanju blagostanja i produljenju čovjekova životnog vijeka, ostvarenje toga vidi u razvoju i primjeni digitalnih tehnologija. Upravo zbog toga, ovaj uspostavni istraživački projekt ima namjeru, prije svega, kritički analizirati etičke i društvene implikacije razvoja i primjene pojedinih digitalnih tehnologija (umjetne inteligencije, velikih podataka, digitalne fenotipizacije) u domeni zdravstvene skrbi. Važnost ovog istraživačkog projekta ogleda se u dvojakoj svrhovitosti, koja se manifestira u dvije glavne faze projekta i to prvoj znanstveno-istraživačkoj i drugoj organizacijsko-institucionalnoj, posjedujući međusobno ovisne i povezane ciljeve. Znanstveno-istraživačka faza sastoji se od teorijskog i empirijskog dijela, koji u svojoj sinergiji pružaju kompletnu sliku o etičkoj i društvenoj prihvatljivosti novih tehnologija u sektoru zdravstvene skrbi. Sastoji se od više istraživačkih ciljeva, a prvi među njima jest ispitati i provjeriti postoje li novi etički i društveni problemi ili izazovi u primjeni digitalnih tehnologija u području zdravstva, te mogu li se već postojeći instrumenti, načela i teorije u bioetici i medicinskoj etici nositi s ovim novim tehnologijama ili je zapravo, potrebna njihova određena evolucija u novu disciplinu ili subdisciplinu digitalne medicinske etike ili bioetike. Empirijski dio znanstveno-istraživačkog dijela odnosi se na ispitivanje kvalitativnom i kvantitativnom metodologijom percepcije i prihvaćenosti novih tehnologija točnije iščekivanja, strahova te potencijalnih problema zainteresiranih sudionika liječnika, pacijenata, inženjera i studenata medicine. U svojoj organizacijsko-institucionalnoj fazi projekt ima za cilj osnovati istraživačku grupu i Laboratorij za etiku digitalnih tehnologija u zdravstvu (Digit-HeaL).]]></summary_hr><summary_en><![CDATA[Healthcare today, more than ever before, is affected by many factors from the shortage of an educated labour force, to the complexity of diseases requiring specific rationalisation leading to increased welfare and the prolongation of the human life span, being relevant to the development and use of digital technologies. Therefore, this installation research project aims, primarily, to analyse the ethical and social implications of technological development critically, and use of digital technologies (artificial intelligence, big data, digital phenotyping) in the healthcare domain. The relevance of this project is reflected in its dual purpose developed through two project phases: the first being scientific-research and the second being an institutional-organisational phase. The former comprises the theoretical and empirical part, providing a complete picture of the ethical and social acceptability of these new technologies within the healthcare sector. The project itself comprises more research goals, the first being to investigate and check whether there exist new ethical and social issues or challenges arising from the digital technologies used within healthcare. The second goal is to verify whether the existing instruments, principles and theories in bioethics and medical ethics can be useful in dealing with these new technologies, or, whether they require particular evolution in the form of a new discipline or sub-discipline of digital medical ethics or bioethics. The empirical part refers to the investigation using qualitative and quantitative methodologies to examine the perception and acceptance of these new technologies in terms of the precise expectations, fears and potential issues as perceived by stakeholders: physicians, patients, engineers and medical students. Besides these research goals, this project, in its institutional-organisational phase, aims to establish a research group and found a digital healthcare ethics laboratory (Digit-HeaL).]]></summary_en></project><project>
<id>12481</id><title_hr><![CDATA[Struktura i funkcija mikrobnih zajednica kao karika koja nedostaje pri procjeni stanja okoliša u obalnim zonama pod antropogenim opterećenjem]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5324</user_id><user_firstLast_name>Ines Sviličić Petrić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-5124</code><acronim><![CDATA[MicroLink]]></acronim><duration>14.10.2021 - 14.01.2026</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Interdisciplinarne prirodne znanosti, </scie_field_hr><scie_field_en>Interdisciplinary natural sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>865099</team_members_id><team_members_names><![CDATA[ Doktorand: Ana Ramljak ]]></team_members_names><keywords_hr><![CDATA[bioindikator, DSO, mikrobne zajednice, bentos, struktura, funkcija, katabolički geni, ekološko stanje okoliša, onečišćenje, luke, Jadran]]></keywords_hr><keywords_en><![CDATA[bioindicator, GES, microbial community, sediment, structure, function, catabolic gene, ecological quality, anthropogenic pollution, harbours, Adriatic]]></keywords_en><summary_hr><![CDATA[Morski okoliši danas su kontinuirano podvrgnuti snažnim utjecajima višestrukih antropogenih pritisaka. U svrhu očuvanja ekosustava Sredozemlja i Jadrana, kao nosioca iznimne biološke raznolikosti, Mediteranske zemlje potpisale su stoga niz inicijativa i Direktiva. Kombinirajući i integrirajući različite pristupe koje proizlaze iz potisanih inicijativa, učinjeni su znatni pomaci za očuvanje ovih ekosustava, no ipak, programi zaštite morskog okoliša još uvijek se suočavaju s mnogim izazovima. MicroLink projekt usmjeren je na istraživanje mikrobne komponente morskih ekosustava, potpuno zanemarene u kontekstu Direktiva, a vođen je idejom da upravo mikrobne zajednice mogu ponuditi rješenje za neke od izazova programa zaštite morskih ekosustava: (i) izazov utvrđivanja utjecaja višestrukih stresora na stanje morskog okoliša, (ii) mogućnost nadogradnje postojećih bioloških pokazatelja uvođenja “novih” indikatorskih elemenata, (iii) potencijal korištenja brzih i pouzdanih suvremenih molekularnih alata pri procjeni stanja okoliša te (iv) problem vezan uz procjenu stanja bentoske komponente ekosustava. Mikroorganizmi čine dominantnu frakciju morskih ekosustava te igraju ključnu ulogu u biogeokemijskim ciklusima kruženjima stoga je neminovno da će promjene inducirane na razini ovih zajednica imati jak utjecaj na cjelokupnu hranidbenu mrežu. MicroLink je zamišljen kao multidisciplinarni projekt inovativnog pristupa koji integrira istraživanje mikrobnih zajednica na 4 različite trofičke razine (bakterije, arheje, gljive i virusi) koristeći 4 metodološka pristupa dajući nam uvid u ponašanje i dinamiku mikrobnih zajednica u zonama pod snažnim pritiscima ljudskih aktivnosti. Ovim projektom planira se odgovoriti na otvoreno pitanje o važnosti te doprinosu praćenja mikrobnih zajednica pri postizanju Dobrog Stanja Okoliša (DSO) time predstavljajući prvi korak pri potencijalnoj integraciji mikrobnih pokazatelja na listu bioloških pokazatelja ekološkog stanja morskog okoliša.]]></summary_hr><summary_en><![CDATA[With anthropogenically-driven pressures drastically changing marine coastal ecosystems much international efforts have been focused on its protection. For that reason, Mediterranean states have accepted numerous regional and international contracts. Even though much effort has been given into protection of marine ecosystems by combining and integrating approaches from WFD and MSFD, these tools are still facing many challenges. Within the frame of the MicroLink project we will focus on the anthropogenic pressures effects onto benthic microbial assemblages, fully neglected in the quality legislation protocols. We believed that microbial assemblages could offer potential answer to some of the challenges facing marine protection programmes: (i) challenge of determining effects of multiple pollution pressures on the integrity of the coastal marine ecosystem, (ii) possible improvement of the existing biological indicators pool (iii) potential of applying fast and reliable state-of-the-art approaches to determine structural and functional integrity of marine ecosystems; and (iv) problems associated with assessment of the ecological status of marine sediments. We will tackle the issue by an innovative approach in which we will combine multi-trophic (bacteria, archaea, virus, fungi)/ multilayer approach for studying microbial communities in anthropogenically-impacted vs. reference environments. Microbes dominate marine ecosystems and have pivotal role in biogeochemical cycling and consequently changes exerted on the level of these communities could alter the whole food web, eventually impairing marine ecosystem services. Within this project we intend to focus on an urgent need to define possible contribution and importance of monitoring microbial assemblages in achieving of Good Environmental Status (GES) which could offer us first step toward potential integration of microbial assemblages as indicators of marine environment quality.]]></summary_en></project><project>
<id>12482</id><title_hr><![CDATA[Analiza strukturnih čimbenika konvergencije Republike Hrvatske tijekom tranzicijskog procesa]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4150</user_id><user_firstLast_name>Josip Tica</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-2484</code><acronim><![CDATA[CONVRH]]></acronim><duration>02.11.2021 - 02.11.2025</duration><status>Prekinut</status><financ_value></financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, </scie_field_hr><scie_field_en>Economy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Ekonomski fakultet u Zagrebu]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Economics and Business]]></institution_en><team_members_id>865142</team_members_id><team_members_names><![CDATA[ Doktorand: Matija Matić ]]></team_members_names><keywords_hr><![CDATA[Tranzicija, konvergencija, ekonomski rast, faktori rasta, strukturne promjene, sektorske promjene, inovacije, globalni lanci vrijednosti]]></keywords_hr><keywords_en><![CDATA[Transition, convergence, economic growth, growth factors, structural change, relative shares of sectors, innovations, global value change]]></keywords_en><summary_hr><![CDATA[Čitav niz dosadašnjih istraživanja ukazao je ispravnost empirijske činjenice kako je Hrvatska tijekom posljednjih 27, odnosno gotovo 40 godina relativno zaostala za okruženjem. S izuzetkom nekih općenitih ideološki obojenih kritika stanja i razvoja ekonomije, ekonomska istraživanja nisu otišla u smjeru otkrivanja ključnih uzroka navedene stagnacije odnosno relativnog ekonomskog zaostajanja. Cilj ovoga istraživanja je pronaći ključne čimbenike koji objašnjavaju ekonomske (ne)uspjehe tranzicijskih zemalja u kontekstu teorija rasta, strukturnih promjena, tržišta rada, tržišta kapitala i sektorske analize. Najvažniji ishodi navedenog istraživanja trebali bi ponuditi podlogu na kojoj bi se mogla povesti činjenično utemeljena rasprava o rješavanja nagomilanih razvojnih problema hrvatskog gospodarstva. Osnovni učinak istraživanja trebao bi biti rasvjetljavanje različitosti zabilježenih u razvojnom putu Hrvatske i ostalih tranzicijskih zemalja tijekom posljednjih 30 godina tranzicije, ispitivanje korelacije i kauzalne veze između specifičnosti hrvatskog razvojnog puta, makroekonomskih agregata i relativnog gospodarskog zaostajanja. Očekivani znanstveni rezultati istraživanja su objava do (ovisno o trajanju recenzije) 11 radova u znanstvenim časopisima citiranim u WoS ili Scopus bazama podataka. Objava jednog poglavlja u knjizi kod svjetski renomiranog izdavača. Prezentacija 4 rada na domaćim i 11 prezentacija rezultata istraživanja na relevantnim međunarodnim konferencijama. U metodološkom smislu fokusirati ćemo se na sofisticirane ekonometrijske metode (PVAR, prostorna ekonometrija, log-t-testovi  konvergencije, dinamički threshold panel modeli...) kako bi maksimalno povećali izglede za objavljivanje u gornjim kvartilima, te stoga planiramo organizaciju 2 ekonometrijske radionice renomiranih gostujućih profesora iz područja panel ekonometrije i ekonometrije vremenskih serija. U posljednjoj godini projekta planiramo završni skup i prezentaciju rezultata na skupu u HAZU-u. ]]></summary_hr><summary_en><![CDATA[A large number of studies have confirmed stylized fact about relative divergence of Croatia during the last 27-40 years vis-a-vis comparable transition countries. With the exception of several ideologically biased analyses of the causes of divergence, economic research did not provide any sound proofs or evidence about key factors of relative divergence and absolute economic stagnation in Croatia. The aim of this research is to identify key factors of convergence within the transition process in terms of economic growth, structural changes, labour market, stock market, and sector analysis. The key results of the research will provide fundamentals for an objective discussion and policy recommendation necessary to address development issues of the Croatian economy. The main impact of the research will be an identification of differences in the development in Croatia vis-a-vis  other post-transition countries during the last thirty years. We will focus on the correlation and causality between specific development patterns in Croatia with macroeconomic aggregates and relative economic divergence. Project’s expected results are publication and/or submission (depending on the review process) of up to eleven research papers in the journals indexed in the WoS or Scopus databases, publication of a chapter in a book published by an internationally recognized publisher. Four paper presentations at local conferences, and eleven paper presentations at international conferences. We plan to use sophisticated methodological approach (PVAR, dynamic threshold panel models, t-log tests of convergence, spatial econometrics...)  in order to increase our chances of publishing in upper quartiles. Therefore, we plan to organize two econometric workshops with international visiting scholars in the field of advanced panel data econometrics and time series econometrics.  Furthermore, in the last year we plan to organize a conference in the Croatian academy of sciences and arts (HAZU).]]></summary_en></project><project>
<id>12484</id><title_hr><![CDATA[Strojno učenje za prijenos znanja u medicinskoj radiologiji]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1485</user_id><user_firstLast_name>Ivan Štajduhar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-6744</code><acronim><![CDATA[RadiologyNET]]></acronim><duration>04.10.2021 - 03.10.2025</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Tehnički fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Engineering]]></institution_en><team_members_id>865061</team_members_id><team_members_names><![CDATA[ Doktorand: Mateja Napravnik ]]></team_members_names><keywords_hr><![CDATA[strojno učenje, duboko učenje, učenje prijenosom znanja, voluminozni podaci, analiza slike, računalom potpomognuto dijagnosticiranje, medicina ]]></keywords_hr><keywords_en><![CDATA[machine learning, deep learning, transfer learning, big data, image analysis, computer-aided diagnosis, medicine]]></keywords_en><summary_hr><![CDATA[Medicinska radiologija često se koristi u kliničkoj analizi za postavljanje medicinske dijagnoze na neinvazivan način. Razmatranjem morfoloških karakteristika promatranog područja, kliničari mogu odrediti prisutnost ozljede ili bolesti bez potrebe za provedbom invazivnog zahvata. Svrha računalno potpomognute dijagnostike (CAD) je liječnicima pružiti pomoć u interpretaciji zabilježenih podataka. U posljednje je vrijeme primjena tehnika strojnog učenja počela uzimati maha u ovom području, povećavajući točnost ručno stvorenim modelima ili ih čak u potpunosti zamjenjujući. Recentan očigledan porast primjene tih tehnika u analizi medicinskih slika omogućen je zbog šire dostupnosti podataka, povećane procesne moći računala i znantnijeg napretka ostvarenog korištenjem postupaka dubokog učenja u primjenama računalnog vida. Ovaj je razvoj pak stvorio potencijal za uvođenje značajnih promjena u biologiji i medicini, kako laboratorijskoj, tako i kliničkoj. Jedna od bitnih prednosti tehnika strojnog učenja u medicini u odnosu na tehnike filtriranja leži u njihovoj sposobnosti otkrivanja novih postupaka dijagnosticiranja bolesti, dotad nezamislivih. Dodatno, zbog kompleksnosti modeliranja stanja usko vezanog uz karakteristike pacijenta, tehnike strojnog učenja počele su uzimati maha kao bitan čimbenik u implementaciji personalizirane medicine u klinici. Predloženo istraživanje unaprijedit će postojeće znanje vezano uz modeliranje u analizi medicinskih slika uvođenjem zajedničke platforme za učenje prijenosom znanja za izgradnju preciznijih prediktivnih modela, namijenjenih automatizaciji postupaka otkrivanja bolesti i ozljeda u medicinskim CAD sustavima, što će u konačnici rezultirati poboljšanjem zdravstvene skrbi.]]></summary_hr><summary_en><![CDATA[Medical radiology is often used in clinical analysis to establish a medical diagnosis in a non-invasive manner. By considering the morphological properties of the observed area, clinicians can determine the presence of an injury or a disease without the need for invasive surgery. The purpose of computer-aided diagnosis (CAD) is to help physicians with interpreting the recorded data. Recently, the use of machine learning techniques has begun to grow rapidly in this area, increasing the accuracy of manually-crafted models, or even entirely replacing them. A recent apparent increase in the use of these techniques in medical image analysis has been facilitated due to a wider availability of data, increased computer processing power, and a more significant progress achieved through the use of deep-learning techniques in machine vision applications. This development, in turn, has created the potential for introducing significant changes to biology and medicine, both in the laboratory and in the clinic. One of the essential advantages of machine-learning techniques, in comparison to the filtering techniques, in medicine, lies in their ability to unearth new procedures for diagnosing diseases, such that have been inconceivable so far. Additionally, due to the complexity of modelling specific conditions, closely related to patient&#39;s characteristics, machine-learning techniques are increasingly becoming an essential factor in the implementation of personalized medicine in the clinic. The proposed research will advance existing knowledge concerning modelling for medical image analysis, by introducing a common transfer-learning platform for building more accurate predictive models, intended to automate disease and injury detection procedures in medical CAD systems, ultimately resulting in improved health care.]]></summary_en></project><project>
<id>12485</id><title_hr><![CDATA[Nanokompoziti s perovskitima za fotovoltaike, fotokatalizu i senzoriku]]></title_hr><title_en><![CDATA[]]></title_en><user_id>2580</user_id><user_firstLast_name>Igor Lukačević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-2147</code><acronim><![CDATA[NanoPeroPhotoSens]]></acronim><duration>21.02.2022 - 21.04.2026</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Odjel za fiziku]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Department of Physics]]></institution_en><team_members_id>865293</team_members_id><team_members_names><![CDATA[ Doktorand: Ivan Kovač ]]></team_members_names><keywords_hr><![CDATA[perovskitni oksidi, BaTiO3, oksidni perovskiti na bazi Mn, nanostructure, nanokompoziti, fotovoltaici, fotokataliza, senzorika]]></keywords_hr><keywords_en><![CDATA[perovskite oxides, BaTiO3, Mn-based oxide perovskites, nanostrucures, nanocomposites, photovoltaics, photo-catalysis, sensing]]></keywords_en><summary_hr><![CDATA[Projekt će biti nastavak istraživanja provedenih u prethodnom razdoblju, posvećenih mogućnosti podešavanja svojstava tankih filmova za uporabu u fotoosjetljivim uređajima, modificiranjem njihove strukture i sastava. Istraživati će se nano-strukture i nanokompoziti koji imaju poseban oblik, kao što su nanocjevčice, nano-štapići i vrlo tanki slojevi. Za dodatnu prilagodbu svojstava, modificirat će se kemijski sastav i struktura površine filmova elektrokemijskim jetkanjem, prekrivanjem nanočesticama i tretmanom u reaktivnim plinovima. Podrška eksperimentalnom radu u postizanju ciljanih svojstava za fotonaponsku, senzorsku i fotokatalitičku primjenu, bit će teorijska predviđanja temeljena na DFT računu elektronske strukture pojedinih materijala i nanokompozita. Eksperimenti na ZnO i TiO2, provedeni u prethodnom projektu, bit će prošireni na oksidne materijale koji imaju perovskitnu strukturu, počevši od BaTiO2 i perovskita na bazi Mn. U daljnjim koracima, funkcionalnost istraživanih tankih filmova će biti istražena njihovom integracijom u dvoslojne i višeslojne strukture relevantne za pojedinu vrstu fotoosjetljivih uređaja.Za pripravu i modifikaciju tankih filmova će se koristiti razne fizikalne i kemijske metode. Strukturna i funkcionalna svojstva će se određivati standardnim tehnikama i korelirati s parametrima formiranja, što će omogućiti bolji uvid u procese relevantne za rast tankog filma. Dobiveni eksperimentalni podaci, u kombinaciji s teorijskim predviđanjima temeljenim na DFT izračunima, rezultirati će boljim razumijevanjem utjecaja sastava i nanostrukture na makroskopska svojstva. Ovo će omogućiti procjenu u kojoj mjeri je moguće, postupcima korištenim u projektu, poboljšati svojstava fotovoltaika, fotokatalizatora i senzora. Dobiveni rezultati će biti objavljeni u časopisima s visokim faktorom odjeka iz područja znanosti o materijalima.Projekt će biti djelomično posvećen obrazovanju diplomskih i doktorskih studenata što podrazumijeva i razvoj novih karijera.]]></summary_hr><summary_en><![CDATA[Project will be continuation of research conducted in the previous period, devoted to exploring possibility of tailoring thin film properties by structural and compositional modification, for use in photosensitive devices. The nano-sized structures and nanocomposites with specific shape as nanotubes, nanorods and thin layers will be investigated. For additional adjustment of properties, the surface chemistry and structure will be modified by electrochemical etching, decoration with nanoparticles and treatment in reactive gases. The achievement of preferred properties targeting for the photovoltaic, sensing and photo-catalytic application will be supported by prediction of theoretical study, based on DFT calculation of electronic structure of individual materials and nanocomposites. The experiments on ZnO and TiO2, done in previous project, will be extended on oxide materials having perovskite structures, starting with BaTiO2 and Mn based perovskites. In further steps, the functionality of studied thin films will be tested by integration in bi-layer and multilayer structures as a part of photosensitive device.For preparation and modification of thin films, various physical and chemical methods will be used. Their structural and functional properties will be determined by using standard techniques and correlated with parameters of formation, enabling better insight into the processes relevant for the thin film growth. The obtained experimental data, combined with theoretical predictions based on DFT calculations, will lead to better understanding of the influence of composition and nanostructure on macroscopic properties. It will enable the evaluation of possibilities of using applied approaches for improving properties of photovoltaics, photo-catalysts and sensors. The results will be published in the high ranking journals in the field of material science.Project will be partially devoted to education of the graduate and PhD students implying new careers development.]]></summary_en></project><project>
<id>12486</id><title_hr><![CDATA[Crijevne bolesti u djece: pogled izvan probavnog sustava]]></title_hr><title_en><![CDATA[]]></title_en><user_id>2694</user_id><user_firstLast_name>Iva Hojsak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-4702</code><acronim><![CDATA[AUTORUNGUT]]></acronim><duration>15.11.2021 - 15.11.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Clinical sciences, </scie_field_en><institution_hr><![CDATA[Klinika za dječje bolesti Zagreb]]></institution_hr><institution_en><![CDATA[Children's Hospital Zagreb]]></institution_en><team_members_id>865196</team_members_id><team_members_names><![CDATA[ Doktorand: Paola Blagec ]]></team_members_names><keywords_hr><![CDATA[kronične upalne bolesti crijeva, iritabilni kolon, autonomni živčani sustav, tjelesna aktivnost, djeca]]></keywords_hr><keywords_en><![CDATA[inflammatory bowel disease, irritable bowel syndrome, autonomic nervous system, physical activity, children]]></keywords_en><summary_hr><![CDATA[Iako su kronične upalne bolesti crijeva (IBD) i sindrom iritabilnog kolona (IBS) vrlo različite bolesti, čija se etiopatogeneza, tijek, liječenje i komplikacije uvelike razlikuju, ove bolesti imaju i brojne sličnosti. Uzrokuju bolove u trbuhu, promjene u stolici, smanjuju kvalitetu života bolesnika, a sve ih također odlikuje kronična upala. Usto, u bolesnika s IBD-ijem koji nije aktivan, simptomi su često posljedica funkcijskog poremećaja za čiju patogenezu se odgovornom smatra disfunkcija osovine mikrobiota-crijevo-mozak. Ova osovina ima dvosmjerno djelovanje, crijevne promjene imaju utjecaj na neurološki sustav (osjet boli), ali i neurofiziološki čimbenici mogu djelovati na crijevo putem autononog živčanog sustava (ANS). Iako se navedeno čini zanimljivim u teoriji, malo je istraživanja, posebice u pedijatrijskoj populaciji, koja su pokušala dokazati ulogu osovine mikrobiota-crijevo-mozak u pojavi simptoma. Osim toga, ostaje nepoznato mogu li vanjske promjene kao što je fizička aktivnost djelovati na ovu osovinu. Postoje ograničeni podaci u odraslih ispitanika koji potvđuju da fizička aktivnost, ne samo da poboljšava tjelesnu spremnost već da pozitivno djeluje na mentalno zdravlje, sastav crijevne mikrobiote, tonus ANS-a, bolju kontrolu simptoma i poboljšanje kvalitete života. U djece nema nikakvih relevantnih znanstvenih istraživanja. Ova će studija pokušato procijeniti važnost pojave disfunkcije ANSa te disbioze u djece s IBSom u usporedbi s IBD-jem u remisiji i zdravim kontrolama. Osim toga nastojat će utvrditi može li strukturirana tjelesna aktivnost polučiti promjene u ANSu i crijevnoj mikrobioti čineći ju sličnijima onoj zdrave populacije (zdrave kontrole). Osim toga utvrdit će se poboljšava li ona kvalitetu života i sastav tijela u djece s IBD-jem u remisiji i IBS-om. ]]></summary_hr><summary_en><![CDATA[Although inflammatory bowel disease (IBD) and irritable bowel syndromes (IBS) are very different diseases, whose etiopathogenesis, course, treatment and complications significantly differ, these diseases also have similarities; cause abdominal pain with changes in frequency and consistency of the stool, significantly affect the patients quality of life (QoL), and in both diseases there are signs of mild active intestinal inflammation. In addition, in IBD patients, in the absence of disease activity, symptoms are largely attributable as functional for which pathogenesis the microbiota-gut-brain axis is recognized as crucial. This axis has a two-way effect, the changes in the intestine have neurological repercussions (sensory of pain) but also neuropsychological factors may have an effect on the digestive system through the autonomic nervous system (ANS).  Although interesting in theory, minimal has been done in the terms of research in pediatric population to clarify this hypothesis of microbiota-gut-brain axis involvement in the symptoms.  Strategy which remains unclear is whether outside stimuli like physical activity could induce change in the microbiota-gut-brain axis. There are some data in adults showing that physical activity is associated with improvements, not only in physical fitness, but also in mental health, microbiome composition, ANS tone, better symptoms control and QoL improvement. There are no data for pediatric population. This study will try to evaluate whether there is a significant pattern of intestinal microbiota and ANS disfunction in children with IBS and IBD in remission and whether inclusion in structured physical activity can change their microbiota composition and ANS function more towards healthy controls. It would be of interest to see whether physical activity further improves QoL and body composition in both groups of patients.]]></summary_en></project><project>
<id>12487</id><title_hr><![CDATA[Numerical modelling of the Adriatic-Ionian decadal and inter-annual oscillations: from realistic simulations to process-oriented experiments]]></title_hr><title_en><![CDATA[]]></title_en><user_id>862794</user_id><user_firstLast_name>Clea Denamiel</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-7189</code><acronim><![CDATA[]]></acronim><duration>02.11.2021 - 01.05.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Geofizika, </scie_field_hr><scie_field_en>Geophysics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>865095</team_members_id><team_members_names><![CDATA[ Doktorand: Iva Tojčić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>12490</id><title_hr><![CDATA[Interakcija dipeptidil peptidaze III s proteinom SH2 domain-containing protein 3C – moguća veza između odgovora na oksidativni stres i stanične migracije ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4619</user_id><user_firstLast_name>Mihaela Matovina</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-1504</code><acronim><![CDATA[OxMiLink]]></acronim><duration>11.10.2021 - 11.01.2026</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Interdisciplinarne prirodne znanosti, </scie_field_hr><scie_field_en>Interdisciplinary natural sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>865097</team_members_id><team_members_names><![CDATA[ Doktorand: Lea Barbarić ]]></team_members_names><keywords_hr><![CDATA[DPP III, SH2D3C, protein-protein interakcije, Nrf2/KEAP1 signalni put, oksidativni stres, migracija stanica]]></keywords_hr><keywords_en><![CDATA[DPP III, SH2D3C, protein-protein interactions, Nrf2/KEAP1 signaling pathway, oxidative stress, cell migration]]></keywords_en><summary_hr><![CDATA[Dipeptidil peptidaza III (DPP III) je cink-ovisna metalopeptidaza koja uzastopno odcjepljuje dipeptide s amino-kraja 3 do 10 aminokiselina dugih peptida te je široko rasprostranjena u organizmima od bakterija do ljudi. Smatra se da ima ulogu u završnim stadijima proteinskog metabolizma u stanici te u regulaciji krvnog tlaka i boli.  DPP III je također uključena u regulaciju Nrf2/KEAP1 signalnog puta kroz kompetitivno vezanje na protein KEAP1 koje dovodi do oslobađanja transkripcijskog faktora Nrf2 i aktivacije odgovora na oksidativni stres. U potrazi za drugim proteinskim interaktorima DPP III, pomoću SILAC-MS metode, identificiran je protein SH2 domain-containing protein 3C (SH2D3C) kao potencijalni interaktor. Interakcija je potvrđena na prekomjerno eksprimiranim proteinima korištenjem nekoliko biokemijskih metoda. SH2D3C je jedan od tri člana proteinske NSP obitelji koji sadrže domenu SH2, RasGEF sličnu domenu te regiju bogatu prolinima i serinima između tih dviju domena. SH2D3C i ostala dva člana porodice (SH2D3A and BCAR3) djeluju kao adaptorski i konstrukcijski proteini koji kontroliraju migraciju stanica integriranjem prijenosa signala preko faktora rasta i integrina, ali precizni način njihovog djelovanja još uvijek je nepoznat. U predloženom istraživanju planiramo potvrditi interakciju na endogenim proteinima, utjecaj svakog od proteina na stanične procese u kojima sudjeluju prekomjernom ekspresijom proteina te izbacivanjem (engl. knock out) gena, odrediti afinitet vezanja pomoću biofizičkih metoda te predvidjeti mjesta vezanja molekulskim modeliranjem. Rezultati predloženog istraživanja omogućit će bolje razumijevanje uloge DPP III u signalnim putevima u koje je uključen SH2D3C i obratno. Imajući u vidu da su kontrola migracije stanica i signalni put Nrf2/KEAP1 često narušeni u raku, rezultati predloženog istraživanja mogli bi otvoriti nove mogućnosti za detekciju biomarkera i liječenje raka. ]]></summary_hr><summary_en><![CDATA[Dipeptidyl peptidase III (DPP III) is a zinc metallopeptidase that sequentially cleaves off dipeptides from the amino-termini of 3 to 10 residue long peptides, ubiquitously present in organisms from bacteria to human. It has assumed role in the final stages of protein turnover in the cell, and in the regulation of blood pressure and pain. DPP III is also involved in the regulation of Nrf2/KEAP1 signalling pathway mediated by the competitive binding to KEAP1 protein that leads to the release of Nrf2 transcription factor and the activation of the oxidative stress response. In the search for other interactors of DPP III by SILAC-MS approach, SH2 domain-containing protein 3C (SH2D3C) was identified as a putative interactor. The interaction was confirmed on overexpressed proteins by several biochemical methods. SH2D3C is one of the three members of the NSP family of proteins which contain both SH2 domain, RasGEF-like domain, and a proline/serine rich region in between. SH2D3C and the other two members of the same family (SH2D3A and BCAR3) serve as adaptor or scaffolding proteins that control cell migration by integrating growth factor and integrin signalling, however, the exact mode of their action is still unknown. We propose to confirm the interaction between endogenous DPP III and SH2D3C and investigate the effect of each protein on the function of the other by the overexpression and knock-down of the genes, determine the affinity of the binding by biophysical methods, and use molecular modelling to predict the likely binding sites. The results of the proposed investigations will enable better understanding of the role of DPP III in the signalling pathways related to SH2D3C in human cells and vice versa. Considering that the cell migration control and Nrf2/KEAP1 signalling pathways are frequently dysregulated in cancer, the results of the proposed research might offer new possibilities for cancer biomarker identification and treatment.]]></summary_en></project><project>
<id>12492</id><title_hr><![CDATA[Primjena ionizirajućeg zračenja za dobivanje polimernih  nano prevlaka na metalima]]></title_hr><title_en><![CDATA[]]></title_en><user_id>19699</user_id><user_firstLast_name>Katarina Marusic</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-5502</code><acronim><![CDATA[RadMeNano]]></acronim><duration>08.12.2021 - 07.12.2025</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>865234</team_members_id><team_members_names><![CDATA[ Doktorand: Ena Pezić ]]></team_members_names><keywords_hr><![CDATA[umrežavanje zračenjem, ionizirajuće zračenje, polimerne nano prevlake, zaštita metala, masne kiseline]]></keywords_hr><keywords_en><![CDATA[radiation crosslinking, ionising irradiation, polymer nano coatings, metal protection, fatty acids]]></keywords_en><summary_hr><![CDATA[Radijacijsko umrežavanje odnosi se na postupak u kojem se ionizirajuće zračenje gama zrakama ili brzim elektronima koristi za poticanje brzih kemijskih reakcija koje rezultiraju stvaranjem 3D mreža. Ionizirajuće zračenje je homogeno, brzo i ne uključuje upotrebu toksičnih kemikalija te se stoga smatra ekološki prihvatljivim. Umrežavanje učvršćuje prevlake, smanjuje prodor vanjskih molekula, poboljšava mehaničku čvrstoću i kemijsku otpornost, kao i druga funkcionalna svojstva, čineći takve premaze otpornijima i značajno produžujući njihov vijek trajanja.Prikladan način za dobivanje kompaktne, besprijekorne prevlake nanometarske debljine je formiranje tankih samoorganiziranih molekularnih slojeva (SAM). SAM-ovi se spontano formiraju izlaganjem metala otopini koja sadrži organske molekule sa samorganizirajućim svojstvima. Masne kiseline su karboksilne kiseline s dugim alifatskim lancima koje tvore SAM-ove i razgrađuju se većinom u produkte niske toksičnosti, što ih čini ekološki prihvatljivim. Korištenje takvih prevlaka bilo bi netoksično i potpuno sigurno za osobu koja nanosi prevlaku, kao i za osobu koja rukuje tretiranim predmetom. Međutim, SAM-ovi masnih kiselina se relativno lako razgrađuju, stoga je potrebno poboljšati njihovu stabilnost. Cilj predloženog projekta je dobivanje polimerne nano prevlake (PNP) na površini metala radijacijskim umrežavanjem SAM-ova masnih kiselina.U okviru predloženog projekta razvit će se vrlo jednostavna procedura za dobivanje PNP na bakrenoj površini koja se također može primijeniti za zaštitu drugih metalnih površina. Razvijene prevlake bile bi zamjena za tradicionalnu toksičnu i kratkoročnu zaštitu koja se danas koristi. Provedba predloženog projekta u skladu je s politikom usmjerenom prema zaštiti okoliša koja je u fokusu posljednjih desetljeća, gdje se ulažu veliki napori za prelazak s klasične kemije koja učestalo koristi toksične/kancerogene kemikalije i druge onečišćivače na nove i brze tehnologije koje ne štete okolišu.]]></summary_hr><summary_en><![CDATA[Radiation crosslinking refers to the process where high energy radiation, gamma-rays or fast electrons are used to induce a chemical reaction that results in formation of a 3D network. It is homogeneous, fast and avoids the use of toxic chemicals and is therefore considered environmentally friendly. Crosslinking hardens the coatings, reduces penetration of external molecules, improves mechanical strength and chemical resistance, as well as other functional properties making such coatings more resistant and significantly extending their lifetimes.A convenient way to obtain a compact, flawless coating with nano-order thickness is by forming thin self-assembled molecular layers (SAMs). SAMs form spontaneously by mere exposure of a metal to a solution containing organic molecules with self-assembling properties. Fatty acids (FA) are carboxylic acids with long aliphatic chains that form SAMs and biodegrade mainly into low toxic products, which makes them environmentally friendly. The use of such coatings would be non-toxic and completely safe for the person applying the coating, as well as the person handling the coated object. However, FA SAMs biodegrade relatively easy, it is thus necessary to improve their stability. The aim of the proposed project is to obtain a polymer nano coating (PNC) on the surface of metals by radiation crosslinking of FA SAMs.Within the proposed project a very simple procedure will be developed for obtaining PNCs on copper surface that can also be applied for the protection of other metal surfaces. The developed coatings would be a replacement for the traditional toxic and short-termed protection used today. The implementation of the proposed project is in accordance with the policy of environment friendly procurement that has been in focus for the last decades, where large effort is being made to switch from the classical chemistry using toxic/cancerous chemicals and other pollutants to new, swift and environment friendly technologies.]]></summary_en></project><project>
<id>12493</id><title_hr><![CDATA[AI Situational Awareness Foundation for Advancing Automation (ID: 892618)]]></title_hr><title_en><![CDATA[]]></title_en><user_id>7283</user_id><user_firstLast_name>Tomislav Radišić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-9829</code><acronim><![CDATA[]]></acronim><duration>01.11.2021 - 30.04.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Tehnologija prometa i transport, </scie_field_hr><scie_field_en>Transport technology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet prometnih znanosti]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Transport and Traffic Sciences]]></institution_en><team_members_id>865106</team_members_id><team_members_names><![CDATA[ Doktorand: Ivan Tukarić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>12495</id><title_hr><![CDATA[Diofantska geometrija i primjene]]></title_hr><title_en><![CDATA[]]></title_en><user_id>2910</user_id><user_firstLast_name>Filip Najman</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-1403</code><acronim><![CDATA[DIOPHANT]]></acronim><duration>25.11.2021 - 24.11.2025</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>865211</team_members_id><team_members_names><![CDATA[ Doktorand: Petar Orlić ]]></team_members_names><keywords_hr><![CDATA[Diofantove m-torke, eliptičke krivulje, modularne forme, Diofantske aproksimacije, kriptografija]]></keywords_hr><keywords_en><![CDATA[Diophantine m-tuples, elliptic curves, modular forms, Diophantine approximations, cryptography]]></keywords_en><summary_hr><![CDATA[Predloženi projekt će koordinirati i podržati istraživačke aktivnosti hrvatske grupe iz teorije brojeva. Teme istraživanja su: Diofantove m-torke i primjene, diofantske aproksimacije (separacija korijena, p-adski verižni razlomci), eliptičke krivulje i modularne forme. Nedavno su Dujella, Kazalicki, Mikić i Sziksai pokazali da postoje beskonačno mnogo racionalnih Diofantovih šestorki, te riješili problem koji je bio otvoren još od vremena Eulera. Planiramo proučiti geometriju tih šestorki kako bi utvrdili postojanje racionalnih Diofantovih sedmorki. Ti će rezultati biti korišteni za konstrukciju familija eliptičkih krivulja visokog ranga i fiksne torzije. Važan alat za proučavanje Mordell-Weil grupa je algoritam za injektivnost preslikavanja specijalizacije koju su razvili Gusić i Tadić koje namjeravamo generalizirati. Planiramo dokazati neke posebne slučajeve slutnje o regularnosti Diofantovih četvorki i proučavati taj fenomen u parametarskim familijama. Također ćemo razmotriti generalizacije na prstenove cijelih brojeva u poljima kao i općenitije D (n) -m-torke. Freitas, Le Hung i Siksek su nedavno dokazali da su sve eliptičke krivulje nad realnih kvadratnim poljima modularne. Planiramo proučavati modularnost na potpuno realnim kubnim poljima. Kazalicki i Kohen nedavno su otkrili vezu između ranga eliptičnih krivulja i nultočki pridruženih modularnih formi (mod p). Planiramo ovo dalje proučiti i povezati s rezultatima Mazur i Swinnerton-Dyer o analitičkom rangu eliptičkih krivulja. Najpopularniji kriptosustav s javnim ključem danas u upotrebi je RSA. Proučavajući diofantske aproksimacije planiramo razviti neke učinkovite napade na ovaj kriptosustav. Rezultati istraživanja bit će objavljeni u uglednim časopisima i predstavljeni na međunarodnim konferencijama. Ovim će se projektom produbiti naše znanstvene veze s međunarodnim grupama iz teorije brojeva te uvesti mlade znanstvenike u istraživanje.]]></summary_hr><summary_en><![CDATA[The proposed project will coordinate and support research activities of Croatian number theory group. The topics of research are: Diophantine m-tuples and applications, Diophantine approximations (root separation, p-adic continued fractions), elliptic curves and modular forms. Recently, Dujella, Kazalicki, Mikić and Sziksai showed that there are infinitely many rational Diophantine sextuples, and solved the problem that was open from the time of Euler. We plan to study the geometry of these sextuples to determine the existence of rational Diophantine septuplets. These results will be used for the construction of families of elliptic curves of high rank and fixed torsion. An important tool for studying Mordell-Weil groups is the algorithm for the injectivity of the specialization map developed by Gusić and Tadić which we plan to generalize. We plan to prove some special cases of regularity conjecture for Diophantine quadruples, and to study it in parametric families. Also, we will consider generalisations to the rings of integers of number fields, and to more general D(n)-m-tuples. Freitas, Le Hung and Siksek recently proved that all elliptic curves over real quadratic fields are modular. We plan to study the modularity over totally real cubic fields. Kazalicki and Kohen recently discovered the connection between the ranks of elliptic curves and zeros of associated modular forms (mod p). We plan to study this further, and connect it to the results of Mazur and Swinnerton-Dyer on the analytic rank of elliptic curves. The most popular public key cryptosystem in use today is the RSA. Studying Diophantine approximations, we plan to develop some efficient attacks on this cryptosystem. The results of the research will be published in respectable journals and presented on international conferences. Through this project we will intensify our scientific connections with international number theory groups and introduce young researchers to the research in number theory.]]></summary_en></project><project>
<id>12497</id><title_hr><![CDATA[Strukturna karakterizacija faktora uključenih u popravak unakrsnog vezanja DNA-protein]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4272</user_id><user_firstLast_name>Marta Popović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-3613</code><acronim><![CDATA[CRO-SI-LINK]]></acronim><duration>09.12.2021 - 09.06.2026</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>865219</team_members_id><team_members_names><![CDATA[ Doktorand: Marin Kutnjak ]]></team_members_names><keywords_hr><![CDATA[Oštećenja DNA, unakrsno vezanje DNA-protein (DPC), SPRTN proteaza, p97, ACRC, struktura, krio-elektronska mikroskopija, rendgenska kristalografija ]]></keywords_hr><keywords_en><![CDATA[DNA damage, DNA-protein crosslinks (DPCs), SPRTN protease, p97, ACRC, structure, cryo-electron microscopy, x-ray crystallography]]></keywords_en><summary_hr><![CDATA[Unakrsna veza DNK-protein (eng. DNA-protein crosslink; DPC) je DNK lezija sa štetnim učincima na organizam, uključujući pojavu tumora, preuranjeno starenje i neurodegenerativne bolesti. DPC-i se pojavljuju usred nepovratnog kovalentnog vezanja proteina na DNK i kao takvi narušavaju sve DNK transakcije: replikaciju, transkripciju i popravak. Popravak DPC-a (DPCR) je stoga esencijalan stanični put koji se sve do nedavnih otkrića proteaza Wss1 i SPRTN nije smatrao posebnim putom popravka DNK oštećenja. Trenutno se malo zna o molekularnim mehanizmima i strukturama čimbenika uključenih u DPCR.  Do danas, strukturne informacije o DPC-ovima i DPCR čimbenicima ograničene su na fragment koji sadrži aktivno mjesto SPRTN proteaze. Podaci na modelu kvasca ukazuju da SPRTN vjerojatno djeluje s ATP-ovisnom segregazom p97 obitelji AAA, još jednim bitnim proteinom povezanim s DPCR-om. Povrh toga, nedavno smo pronašli novu potencijalnu proteazu, ACRC (syn. GCNA), za koju se pokazalo da je povezana s DPCR-om. Trenutno nedostaju strukturni podaci o interakciji SPRTN-a sa DPC supstratima i p97 segregazom, kao i biokemijski i strukturni podaci o ACRC-u. Cilj nam je (1) okarakterizirati SPRTN:p97 kompleks i pretpostavljenu proteazu ACRC in vitro i in vivo, i (2) riješiti strukture humanih kompleksa SPRTN:DPC i SPRTN:p97 kao i strukturu ACRC proteina. Kompleksi SPRTN-a sa modelnim DPC-om i p97-om biti će rekonstituirani in vitro. Za dobivanje struktura visoke razlučivosti koristiti će se state-of-the-art krio-elektronski mikroskop sa faznom pločom i direktnim detektorom elektrona, dok će se za rješavanje strukture ACRC-a koristiti kristalografija zbog male veličine proteina. Predloženo istraživanje otkriti će mehanizme djelovanja DPCR-a na molekularnoj razini te pridonijeti području razvijanja inhibitora p97-a i SPRTN-a u svrhu liječenja raka i modulacije procesa starenja.]]></summary_hr><summary_en><![CDATA[DNA-protein crosslinks (DPCs) are DNA lesions with adverse effects on the organismal level, including cancer, premature aging and neurodegenerative diseases. DPCs occur when a protein irreversibly covalently binds to DNA and thus impair all DNA transactions: replication, transcription and repair. DPC repair (DPCR) is therefore an essential cellular pathway which was overlooked due to the fact that it was not considered to be a distinct DNA damage repair pathway until recent discoveries of proteases Wss1 and SPRTN with central role in the pathway. However, molecular mechanisms and structural knowledge behind the protease-mediated DPCR is lacking. To date, structural information on DPCs and DPCR factors is limited to a fragment containing the active site of SPRTN protease. Data from yeast indicate that SPRTN might work in concert with the ATP-dependent AAA family segregase p97, another essential protein linked to DPCR. In addition, we have recently found another SPRTN-like putative protease, ACRC (syn. GCNA) shown to be linked to DPCR. Currently, structural data on SPRTN interaction with DPC substrates and p97 segregase is lacking, as well as biochemical and structural data on ACRC. We aim to (1) characterize SPRTN:p97 complex and putative protease ACRC in vitro and in vivo, and (2) solve structures of human SPRTN:DPC and SPRTN:p97 complexes as well as the structure of ACRC protein. SPRTN complexes with a model DPC and a p97 will be reconstituted in vitro.  Structures of high resolution will be obtained using a state-of-the-art cryo-EM facility with phase plate and a direct electron detector, while the structure of ACRC will be solved using X-ray crystallography due to the small size of the protein. The proposed research will unravel the mechanisms underlying DPCR on a molecular level and will contribute to the field of p97 and SPRTN inhibitor development for the purpose of cancer treatment and modulation of aging processes.]]></summary_en></project><project>
<id>12498</id><title_hr><![CDATA[Integracija i dezintegracija Europske unije: Dinamike europeizma i euroskepticizma]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6920</user_id><user_firstLast_name>Nikola Petrović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-6758</code><acronim><![CDATA[IDEU]]></acronim><duration>01.10.2021 - 30.09.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Sociologija, </scie_field_hr><scie_field_en>Sociology, </scie_field_en><institution_hr><![CDATA[Institut za društvena istraživanja]]></institution_hr><institution_en><![CDATA[Institute for Social Research in Zagreb]]></institution_en><team_members_id>865111</team_members_id><team_members_names><![CDATA[ Doktorand: Josip Bilić ]]></team_members_names><keywords_hr><![CDATA[Europska unija, ideologija, povijesne traume, identitet, integracija]]></keywords_hr><keywords_en><![CDATA[European union, ideology, historical grievances, identity, integration]]></keywords_en><summary_hr><![CDATA[Dezintegracija Europske unije izuzetno je aktualno i u sve većoj mjeri istraživano pitanje, kako teorijski, tako i empirijski. U ovom će se projektnom prijedlogu kroz interdisciplinarni pristup, te koristeći inovativnu komparativnu metodologiju i za ovu svrhu rijetko korištene sociološke teorije uspoređivati razvoj i dinamiku europeizma i euroskepticizma. Ideje europeizma i euroskepticizma u vrijeme intenzivne društvene polarizacije ključne su u razumijevanju integracijskih i dezintegracijskih procesa. Bit će izvršena kvalitativna komparacija nositelja europeističkih i euroskeptičnih ideja iz političke i intelektualne elite u pet država članica EU-a iz različitih faza proširenja (Njemačka, Ujedinjeno Kraljevstvo, Španjolska, Poljska, Hrvatska), kao i kvantitativna komparacija utjecaja povijesnih trauma na uspjeh euroskeptičnih stranaka u svim državama članicama EU. Rezultati istraživanja bi trebali doprinijeti razumijevanju utjecaja različitih povijesnih iskustava na različite vizije europske integracije u podijeljenim europskim društvima. Komparacija političkih i intelektualnih aktera koji su radili na izgradnji nadnacionalnog identiteta i njihovih protivnika u socijalističkoj Jugoslaviji i EU trebala bi omogućiti dublje razumijevanje integracijskih i dezintegracijskih procesa u nadnacionalnim organizacijama.Pretpostavljeni učinak uspostave istraživačke grupe je razvijanje intenzivnog interdisciplinarnog pristupa u istraživanju europske integraciji u kojem će biti zastupljene sociološke, politološke, povijesne i filozofske perspektive. Istraživačke i diseminacijske aktivnosti trebale bi doprinijeti deideologizaciji rasprave o europskoj integraciji i europskom identitetu u znanstvenom i javnom prostoru.]]></summary_hr><summary_en><![CDATA[Disintegration of the European Union is a highly relevant research question, which has been recently analysed through innovative theoretical and empirical approaches. This project proposal aims to apply an interdisciplinary approach, innovative comparative methodology and for this purpose rarely used sociological theories in order to compare the development of Europeanism and Euroscepticism.  Europeanism and Euroscepticism are ideas that are crucial for understanding integration and disintegration of the EU. Qualitative comparison of carriers of Europeanist and Eurosceptic ideas from political and intellectual elites in five EU member states representing different enlargement phases (Germany, the United Kingdom, Spain, Poland, Croatia) and quantitative comparison of the effects of historical grievances on electoral results of Eurosceptic parties in all EU member states should contribute to the understanding of the influences of diverse historical experiences on different visions of European integration in divided European societies. Comparison of political and intellectual elites that were trying to build supranational identities and their adversaries in socialist Yugoslavia and in the EU should contribute to a better understanding of integration and disintegration processes in supranational organizations. Another impact of this project proposal should be the establishment of a new research group that will develop an intensive interdisciplinary research approach (sociological, political science, historical and philosophical perspectives) to studying European integration. Research and dissemination activities should contribute to deideologization of scholarly and public debates on European integration and European identity. ]]></summary_en></project><project>
<id>12500</id><title_hr><![CDATA[Utjecaj autohtonih ne-Saccharomyces kvasaca na aromu vina ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1182</user_id><user_firstLast_name>Irena Budić-Leto</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-2070</code><acronim><![CDATA[WINE AROMAS]]></acronim><duration>23.08.2021 - 22.08.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Prehrambena tehnologija, </scie_field_hr><scie_field_en>Food technology, </scie_field_en><institution_hr><![CDATA[Institut za jadranske kulture i melioraciju krša]]></institution_hr><institution_en><![CDATA[Institute for Adriatic Crops and Karst Reclamation in Split]]></institution_en><team_members_id>865017</team_members_id><team_members_names><![CDATA[ Doktorand: Ana Boban ]]></team_members_names><keywords_hr><![CDATA[autohtoni ne-Saccharomyces kvasci, enološki potencijal, aroma, vino, metabolomika]]></keywords_hr><keywords_en><![CDATA[native non-Saccharomyces yeasts, oenological potential, aroma, wine, metabolomics]]></keywords_en><summary_hr><![CDATA[Trenutne spoznaje ukazuju na značajne razlike između sposobnosti S. cerevisiae i ne-Saccharomyces u oslobađanju tiola i pojedinih prekursora arome grožđa. Lipidi su među spojevima u grožđu koji imaju važnu ulogu u kvaščevom metabolizmu jer izgrađuju njihove stanične stijenke. Tolerancija kvasca na stres, što uključuje etanol, octenu kiselinu ili acetaldehid snažno je pod utjecajam lipidnog sastava njegove stanične membrane. Upotreba kvasca dobivenih iz ekosustava vinograda može povećati tipičnost i autentičnost vina iz toga područja, dovodeći mikrobiom vinograda u prvi plan, što se često naziva i mikrobni teroir. Glavni ciljevi predložene studije za sortu „Maraština“  iz obalnog područja Hrvatske su: (i) Izolirati i identificirati autohtone ne-Saccharomyces kvasace; (ii) Karakterizirati enološki potencijal autohtonih ne-Saccharomyces kvasaca; (iii) Utvrditi utjecaj specifičnih autohtonih ne-Saccharomyces kvasaca na sortni i fermentacijski sastav arome vina. U suradnji sa stručnim znanstvenicima u području metabolomskih istraživanja u Fondazione Edmund Mach, Research and Innovative Centre u Italiji, (FEM) definirat ćemo cijeli profil arome grožđa i vina, uključujući spojeve u vrlo niskoj koncentraciji, kako bismo poboljšali razumijevanje utjecaja kvasaca na stvaranje relevantnih kemijskih spojeva. Ovaj će nam skup podataka pomoći u analizi i razumijevanju složenih interakcija između kvasaca i kemijskih spojeva grožđa, prije svega onih koji su odgovorni za aromu sorte i onih sintetiziranih tijekom alkoholne fermentacije grožđa uzgojenog u specifičnim, ekološkim uvjetima, tople mediteranske klime. Ovaj projekt daje uvid u potencijalne nove starter ne-Saccharomyces kulture, s nizom sojeva koje će se karakterizirati s obzirom na njihov potencijalni učinak na profil arome vina. Rezultati ovog projekta bit će korisni za vinsku industriju. To će biti čvrsta znanstvena osnova za odabir autohtonih kvasca koji će vinarima pružiti izgradnju kompleksnijeg stila vina.]]></summary_hr><summary_en><![CDATA[Current knowledge has shown marked differences between S. cerevisiae and non-Saccharomyces ability to release thiols and other varietal aroma precursors available in grape. Lipids are among compounds in grapes which can play an important role in yeast metabolism because they are involved in the structure of yeast cells. Yeast stress tolerance and its resistance to ethanol, acetic acid or acetaldehyde are strongly influenced by lipid composition of its cell membrane. The use of non-Saccharomyces yeasts derived from a vineyard ecosystem may enhance the typicity and authenticity of the wines, bringing the vineyard microbiome to the fore of the terroir concept, often referred to as microbial terroir. The main objectives of the proposed study for ‘Maraština’ grapes are: (i) Isolation and identification of the native non-Saccharomyces yeasts; (ii) Screening of oenological characteristics of the native non-Saccharomyces yeasts; (iii) Determining the influence of specific native non-Saccharomyces yeasts on the varietal and fermentative aroma composition of wine. In cooperation with expert scientists in the field of metabolomics research at Fondazione Edmund Mach, Italy, (FEM) we will define the entire aroma profile, including compounds at very low concentration, to improve understanding of the impact of yeasts on the formation of relevant chemical compounds. This data set will help us to understand the interactions between yeasts and the grape compounds, primarily those responsible for the varietal aroma and those synthesized during the alcoholic fermentation of the variety cultivated in specific ecological conditions of warm Mediterranean climate. This project provides promising insights into potential new non-Saccharomyces starter cultures, with a number of species characterized in terms of potential effect on aroma profile following sequential fermentation with commercial S. cerevisiae strain. The results of this project will be useful for wine industry. ]]></summary_en></project><project>
<id>12501</id><title_hr><![CDATA[Laboratorij za geoprostorne analize]]></title_hr><title_en><![CDATA[]]></title_en><user_id>12395</user_id><user_firstLast_name>Ante Šiljeg</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-5014</code><acronim><![CDATA[GAL / GAL]]></acronim><duration>01.10.2021 - 30.09.2025</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Interdisciplinarno područje znanosti</scie_area_hr><scie_area_en>Interdisciplinary scientific area</scie_area_en><scie_field_hr>Geografija, </scie_field_hr><scie_field_en>Geography, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zadru]]></institution_hr><institution_en><![CDATA[University of Zadar]]></institution_en><team_members_id>865137</team_members_id><team_members_names><![CDATA[ Doktorand: Lovre Panđa ]]></team_members_names><keywords_hr><![CDATA[daljinska istraživanja, GIS, LiDAR, morfometrijske analize, UAV, višekriterijske analize]]></keywords_hr><keywords_en><![CDATA[GIS, LiDAR, morphometric analysis, multi-criteria decision analysis, remote sensing, UAV]]></keywords_en><summary_hr><![CDATA[Osnovni  cilj projekta  je uspostava  Laboratorija  za geoprostorne analize  (GAL)  pri  Odjelu  za  geografiju  Sveučilišta  u  Zadru  te  okupljanje  interdisciplinarnog  tima  znanstvenika  iz  različitih  znanstvenih  polja (geografija,  arheologija, geodezija, agronomija). Osnovna  svrha GAL-a  je  provođenje  znanstvenih  istraživanja,  edukacija  mladih  istraživača, primjena novih znanja i tehnologija te razvoj  inovativnih metoda istraživanja. Prva faza uspostave usmjerena je na opremanje laboratorija s najsuvremenijim  uređajima  uz istovremeno usavršavanje istraživačkog  tima. Primjenom GIS-a u kombinaciji sa korištenjem tehnologije daljinskih istraživanja (bespilotna letjelica, 3D-skener, LiDAR, infracrvena kamera, termalna kamera itd.) omogućava se proučavanje određenog procesa  ili pojave u krupnom mjerilu, pri čemu su sve karakteristike promatranog objekta mjerljivo, odnosno kvantitativno opisane. Stoga je drugi cilj ovog projekta usmjeren na primjenu geoprostornih analiza u primijenjenim istraživanjima kroz  (a)  razvoj   višekriterijskog   modela  održivog  upravljanja   na  području  sedrotvornih vodotoka (b) razvijanje novog metodološkog pristupa u proučavanju  jaruga i (c)  pronalaženje  praktičnih  rješenja  kroz  primjenu  geoprostornih  analiza  u arheologiji i agronomiji. Ostvarenje navedenih ciljeva i izvedeni rezultati pokazali bi primjenjivost i opravdanost laboratorija u daljnjim znanstvenim istraživanjima. Jedinstveni doprinos ostvarenja ovog projekta očituje se u tome da bi GAL predstavljao prvi laboratorij za geoprostorne analize u RH koji će biti usmjeren na usavršavanje te promociju i edukaciju mladih znanstvenika kroz njihovo uključivanje u rad laboratorija. Znanstveni doprinos ovog istraživanja iskazati će se kroz pisanje dvije doktorske disertacije, čiji je osnovni cilj istraživanja izrada prvog plana održivog upravljanja sedrotvornim vodotocima te razvoj novog metodološkog koncepta za proučavanje jaruga. ]]></summary_hr><summary_en><![CDATA[The main aim of the project is to set up a Geospatial Analysis Laboratory (GAL) at the Department of Geography, University of Zadar, and to gather an interdisciplinary team of scientists from various fields (geography, archaeology, geodesy, agronomy). GAL&#39;s basic aim is to produce scientific research, educate young researchers, apply new knowledge and technology, and develop innovative research methods. The first phase of the application focuses on equipping the laboratory with the most up-to-date devices and accompanying software, while training the research team. The use of GIS in combination with RS technology (unmanned aerial vehicle, 3D scanner, LiDAR, infrared camera, thermal camera, etc.) facilitates the study of certain processes or phenomena at close range, while their characteristics are measurable, i.e. can be described quantitatively. Therefore, the second goal of the project focuses on the application of geospatial analyses in applied research through (a) the development of multicriteria models of sustainable management in the area of tufa-forming watercourses, (b) the development of a new methodical approach to studying gullies, and (c) discovering practical solutions through applying geospatial analyses in archaeology and agronomy. Achieving these goals and the results produced would demonstrate to applicability of and justification for GAL in further scientific research. The unique contribution of this project would be the creation of the first laboratory for geospatial analysis in Croatia, focusing on training, promoting and educating young scientists by engaging them in its work. The scientific contribution of this research will be seen in two doctoral dissertations, whose basic research topics are concerned with the production of the first plan for the sustainable management of tufa-forming watercourses, and the development of a new methodological concept for studying gullies. ]]></summary_en></project><project>
<id>12502</id><title_hr><![CDATA[Epigravetijenske zajednice sjeverne Dalmacije]]></title_hr><title_en><![CDATA[]]></title_en><user_id>499</user_id><user_firstLast_name>Dario Vujević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-6734</code><acronim><![CDATA[EpiC]]></acronim><duration>15.10.2021 - 15.04.2026</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Arheologija, </scie_field_hr><scie_field_en>Archeology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zadru]]></institution_hr><institution_en><![CDATA[University of Zadar]]></institution_en><team_members_id>12898</team_members_id><team_members_names><![CDATA[ Doktorand: Mario Bodružić ]]></team_members_names><keywords_hr><![CDATA[Vlakno, Gornji paleolitik, epigravetijen, pleistocen, litika, nakit, koštani alat]]></keywords_hr><keywords_en><![CDATA[Vlakno cave, Upper Palaeolithic, Epigravettian, Pleistocene, Lithic, personal ornaments, bone tools]]></keywords_en><summary_hr><![CDATA[Razdoblje gornjeg paleolitika na području sjeverne Dalmacije izrazito je slabo istraženo. Situacija nije bolja niti ako u obzir uzmemo širi prostor istočnog Jadrana, gdje postoji svega desetak dovoljno istraženih nalazišta iz vremena epigravetijena. Uz to, tek mali broj nalazišta na istočnoj obali Jadrana mogu se datirati u vrijeme starije od 13,000 god. prije sadašnjosti, a posebno su rijetka nalazišta koja se mogu datirati u vrijeme trajanja ili neposredno nakon kasnoglacijalnog maksimuma. Pećina Vlakno na Dugom otoku jedno je od rijetkih koje ima kulturne slojeve iz ovih razdoblja. Nova istraživanja kako u pećini Vlakno, tako i na drugim projektom predloženim lokacijama doprinijet će stoga proučavanju gornjeg paleolitika jugoistočne Europe. Sa znanstvene strane istraživanja će pomoći u definiranju načina na koji su ljudske zajednice mijenjale svoje ponašanje i pružiti važne informacije na temu naseljavanja i kretanja zajednica u razdoblju posljednjeg ledenog doba. Pomoći će u definiranju načina na koji su ljudske zajednice mijenjale svoje ponašanje i pružiti važne informacije na temu naseljavanja i mobilnosti zajednica. Dobiveni podatci lako će se moći inkorporirati u druga slična istraživanja na širem prostoru i tako popuniti praznine koje su do sada postojale vezane uz razdoblje epigravetijena.]]></summary_hr><summary_en><![CDATA[Current state of research of the Northern Dalmatia is quite limited. The situation is not even better if we take the wider area of the eastern Adriatic in consideration. In the eastern Adriatic region there are about ten Epigravettian sites explored in a satisfying manner. Only a small number of sites on the eastern coast of the Adriatic can be dated to the period before 13,000 bp, and sites which can be dated to the period of duration or immediately after the Late Glacial Maximum are particularly rare. Vlakno on the island of Dugi Otok is one of them. New research in the Vlakno Cave and other proposed locations will contribute to the study of the Upper Palaeolithic of Southeast Europe. From the scientific side of the research, it will help define the ways in which human groups have changed their behaviour and provide important information on the questions of communities mobility in the period of the Last Ice Age. The obtained data will easily be incorporated into other similar research in the wider space and thus fill the gaps that have so far been associated with the Epigrevattian period.]]></summary_en></project><project>
<id>12503</id><title_hr><![CDATA[Odgovor ozime pšenice na biotičke i abiotičke stresove izazvane klimatskim promjenama]]></title_hr><title_en><![CDATA[]]></title_en><user_id>273</user_id><user_firstLast_name>Valentina Španić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-1662</code><acronim><![CDATA[]]></acronim><duration>01.09.2021 - 31.08.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Poljoprivredni institut Osijek]]></institution_hr><institution_en><![CDATA[Agricultural Institute Osijek]]></institution_en><team_members_id>865058</team_members_id><team_members_names><![CDATA[ Doktorand: Jurica Duvnjak ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>12505</id><title_hr><![CDATA[Razvoj bioaktivnih molekula za tretman neurodegenerativnih bolesti]]></title_hr><title_en><![CDATA[]]></title_en><user_id>991</user_id><user_firstLast_name>Anita Bosak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-4835</code><acronim><![CDATA[BioMol4ND]]></acronim><duration>01.10.2021 - 30.01.2026</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut za medicinska istraživanja i medicinu rada]]></institution_hr><institution_en><![CDATA[Institute for Medical Research and Occupational Health]]></institution_en><team_members_id>865028</team_members_id><team_members_names><![CDATA[ Doktorand: Marija Bartolić ]]></team_members_names><keywords_hr><![CDATA[Alzheimerova bolest, inhibicija kolinesteraza, selektivnost prema BChE, karbamati, oksidativni stres, sinteza, BACE1]]></keywords_hr><keywords_en><![CDATA[Alzheimer&#39;s disease, cholinesterase inhibition, BChE selectivity, MTDL, carbamates, oxidative stress, synthesis, BACE1]]></keywords_en><summary_hr><![CDATA[Primarni cilj projekta je razvoj molekula koje mogu ublažiti simptome i usporiti napredovanje neurodegenerativnih bolesti (ND) koje utječu na neurone, primarno one u ljudskom mozgu, uzrokujući probleme s kretanjem i/ili mentalnim funkcioniranjem. Racionalno će se dizajnirati inhibitori kolinesteraza (ChE) koji se vežu u katalitičko i periferno mjesto aktivnog mjesta ChE, čime jedan spoj može istodobno utjecati na povećanje koncentracije acetilkolina u mozgu i inhibirati Abeta agregaciju. Spojevi sa zadovoljavajućim inhibicijom ChE kao primarnoj farmakofori, poslužili bi kao strukturne baze za MTDL (multi-target-directed-ligands) dizajn dodavanjem dodatnih farmakofora koje bi djelovale na druga obilježja demencije AD tipa (npr. oksidativni stres, homeostaza bimetala), što je primarni cilj projekta. Odredit će se sposobnost spojeva da inhibiraju BACE1 i Abeta agregaciju, prooksidativni/antioksidacijski kapacitet i citotoksičnost kako bi se utvrdila mogućnost njihove uporabe za liječenje ND. Razvoj tako dizajniranih spojeva imat će dva glavna smjera: razvoj CNS aktivnih i razvoj periferno aktivnih spojeva, ovisno o njihovoj sposobnosti prolaska krvno-moždane barijere. Razvoj MTDL lijekova koji istodobno djeluju na nekoliko obilježja AD je u prednosti prema razvoju lijekova koji djeluju na jedno od obilježja ND budući da osigurava dodatni farmakološki odgovor koji može sinergistički modulirati patološku kaskadu u neurodegeneraciji. Trenutno liječenje AD često je kombinacija postojećih lijekova ili uz dodatak onih koji djeluje na druga obilježja ND (npr. kelatori metala). Demencija AD tipa općenito pogađa ljude starije od 65 godina i upotreba velikog broja lijekova predstavlja teret za homeostazu organizma. S obzirom na veliki broj bolesnika koji će u budućnosti bit težak teret za javnozdravstveni sustav, lijekovi koji bi mogli ublažiti ili ukloniti simptome demencije, omogućujući pacijentima da u svakodnevnom životu budu neovisni o tuđoj pomoći, vrlo su potrebni.]]></summary_hr><summary_en><![CDATA[The primary goal of the project is to develop molecules with the potential to alleviate the symptoms and slow down the progression of neurodegenerative diseases (ND) that primarily affect the neurons in the human brain that causes problems with movement and/or mental functioning. The project aims to rationally design dual site binding cholinesterase (ChE) inhibitors (acting on improving the acetylcholine level in the brain and on Abeta aggregation) and use them as starting points for multi-target-directed ligand (MTDL) design by adding an additional pharmacophore in a single molecule entity able to act on other hallmarks of Alzheimer’s type of dementia (e.g. oxidative stress and bimetal dyshomeostasis). Compounds will be biologically evaluated (BACE1 and amyloid beta aggregation inhibition, pro-oxidant/antioxidant capacity, cytotoxicity, etc.) to determine their ability as possible drugs for treatment of ND. The development of these designed compounds will have two major objectives: development of CNS active and development of peripherally active compounds, depending on their ability to cross the blood-brain-barrier. In ND treatment, the development of multitargeted drugs is favourable compared to single-targeted drugs since an additional pharmacological response that might synergistically modulate the pathological cascade in neurodegeneration occurs. Moreover, current treatment of AD often combines currently available drugs, or of does so alongside an additional one acting on other hallmarks of ND (e.g. metal chelators). Considering that the AD type of dementia generally affects people ? 65, the use of a large number of drugs is a major burden for organism homeostasis. Considering the large number of patients that could bring a heavy burden to public health system in the future, the drugs that could alleviate or remove symptoms of dementia, allowing patients to be independent of the help from other people in daily life is very much needed.]]></summary_en></project><project>
<id>12506</id><title_hr><![CDATA[Algoritamske konstrukcije kombinatornih objekata]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4484</user_id><user_firstLast_name>Anamari Nakić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-7483</code><acronim><![CDATA[ACCO]]></acronim><duration>01.02.2022 - 31.01.2026</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>865314</team_members_id><team_members_names><![CDATA[ Doktorand: Filip Martinović ]]></team_members_names><keywords_hr><![CDATA[kombinatorna konstrukcija, algoritam, dizajn, dizajn nad konačnim poljem, parcijalni linearni prostor, jako regularni graf, diferencijski skup]]></keywords_hr><keywords_en><![CDATA[combinatorial construction, algorithm, design, design over finite field, partial linear space, strongly regular graph, difference set]]></keywords_en><summary_hr><![CDATA[Ovaj projektni prijedlog spada u područje konstrukcija kombinatornih objekata s pomoću računala. U fokusu će biti konstrukcije objekata s dodatnom algebarskom strukturom kao što su shematski dizajni, q-analogoni dizajna, mozaici dizajna, kocke dizajna, (polu)parcijalne geometrije i generalizacije. Rezultati iz algebarske kombinatorike postavljaju ograničenja na parametre i svojstva takvih objekata koja se mogu iskoristiti da bi se suzilo prostor pretraživanja i razvili specijalizirani algoritmi za njihovu konstrukciju i klasifikaciju.Glavni ciljevi projekta su razvoj algoritamskih metoda konstrukcije i klasifikacije kombinatorinih objekata s dodatnom algebarskom strukturom i proširivanje teorijskih znanja o takvim objektima. Razvit ćemo softverski paket, implementiran u sustavu za računalnu algebru GAP, za konstrukciju i analizu kombinatornih objekata.]]></summary_hr><summary_en><![CDATA[The proposed project falls into the area of combinatorial constructions of objects with the aid of computers. We will focus on the construction of objects with additional algebraic structure such as schematic designs, q-analogs of designs, mosaics of designs, design cubes, (semi)partial geometries and generalisations. Results in algebraic combinatorics impose restrictions on the parameters and properties of such objects that can be exploited to narrow-down the search space and develop specialised algorithms for their construction and classification.The main objectives of the proposed project are development of algorithmic methods for the construction and classification of combinatorial objects with strong algebraic structure and widening of theoretical knowledge about such objects. We will develop of a software package, implemented in the computer algebra system GAP,for the construction and analysis of combinatorial objects.]]></summary_en></project><project>
<id>12507</id><title_hr><![CDATA[Projekt nedužnosti u Hrvatskoj]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5549</user_id><user_firstLast_name>Leo Cvitanović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-5858</code><acronim><![CDATA[CroINOP]]></acronim><duration>15.11.2021 - 14.11.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Pravo, </scie_field_hr><scie_field_en>Law, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Pravni fakultet u Zagrebu]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Law]]></institution_en><team_members_id>865195</team_members_id><team_members_names><![CDATA[ Doktorand: Andrej Bozhinovski Bozhinovski ]]></team_members_names><keywords_hr><![CDATA[projekt nedužnosti, obnova postupka, DNK analiza, baze podataka, naknadna vještačenja, privatnost]]></keywords_hr><keywords_en><![CDATA[innocence project, reopening of criminal proceedings, DNA analysis, databases, subsequent expert testimony, privacy]]></keywords_en><summary_hr><![CDATA[U  Hrvatskoj ne postoje tzv. projekti  nedužnosti kojima bi se pogrešno osuđenim osobama (nedužnima) omogućila obnova postupka naknadnim vještačenjem DNK u laboratorijima. Baze DNK podataka u Hrvatskoj za sada se vode jedino pri Centru &#39;Ivan Vučetić&#39;, a važne su jer omogućavaju pohranjivanje DNK podataka koji se zatim mogu koristiti u razne svrhe, pa i u svrhe utvrđivanja (ili oslobađanja) počinitelja kaznenih djela. U tom smislu prijedlog ovog projekta ide u smjeru identificiranja najbolje prakse za obnovu postupka na osnovi provedenih naknadnih DNK vještačenja. Za podnošenje tog zahtjeva, potrebno je i dobro skladištenje, tj. (o)čuvanje predmeta koji sadrže materijalne tragove (corpore), s kojih bi se izuzeo i analizirao DNK materijal (Lee, Palmbach, Primorac, Anđelinović 2014, 253-276; Kay, Bieber, Primorac 2014, 509-525). Ukoliko bi rezultati analize pokazali da bi osoba mogla biti oslobođena, savjetovalo bi joj se podnošenje zahtjeva za obnovom postupka temeljenog na novoj činjenici/dokazu. Ujedno bi se sugeriralo i poduzimanje daljnjih odgovarajućih pravnih mjera. Zainteresirane osobe bi ispunjavale tzv. &#39;pismo namjere&#39; za razmatranjem njihovih slučajeva putem mrežnog obrasca na stranicama projekta i/ili koji bi stizao na adresu &#39;sjedišta&#39; projekta. S tim u vezi bi se istraživale i mogućnosti kompenzacija osobama koje su bile pogrešno osuđene u vidu predlaganja donošenja relevantnog zakona ili pravilnika. Uz navedenu ideju kao temeljnu fokusnu točku, dodatno bi se istraživalo izuzimanje DNK u kaznenom postupku te bi se analizirali spisi predmeta u kojima je bila korištena DNK analiza, kao i broj obnova postupka temeljem ove metode. Provelo bi se i istraživanje o tome izuzima li se DNK u svim slučajevima propisanim čl. 174a ZIKZ. Jedna od istraživačkih točaka bila bi i ispitivanje interesa zatvorske populacije o podnošenju zahtjeva za obnovom postupka temeljem DNK analize, uz utvrđivanje eventualno opravdanih zahtjeva i njihovo daljnje procesuiranje. ]]></summary_hr><summary_en><![CDATA[There are no so-called Innocence Projects in Croatia, through which wrongfully convicted (innocent) persons would have the possibility of motioning for a new trial based on subsequent DNA analysis. DNA databases in Croatia are, so far, stored only with the Ivan Vučetić Centre and are essential because they enable the storing of DNA data which can then be used in different ways, including determining (or liberating) the culprits in criminal offenses. In that vicinity, this project proposal means to identify the best practice for a new trial based on subsequent DNA analysis. For motioning such a request, there is a need for proper storage, i.e., guarding of material evidence (corpore), from which DNA material would be extracted and analyzed (Lee, Palmbach, Primorac, Anđelinović 2014, 253-276; Kay, Bieber, Primorac 2014, 509-525). If the results showed that the person could be freed, he/she would be advised to motion for a new trial based on new evidence. Other applicable legal measures would also be recommended. Interested persons would fill out a so-called ‘’letter of intent’’ for the consideration of their cases via the web form on the project’s site and/or which would arrive by post at the project’s HQ. Means of financial compensation for wrongfully convicted persons using legal or normative acts would be considered. Along with the said idea as the main focal point, additional research would be based around extracting DNA in criminal proceedings and the analysis of case files where DNA analysis was used, as well as the number of new trials based on this method. Research would be conducted as to whether DNA is extracted in all cases proscribed by art. 174 of the ZIKZ. One of the points would be an inquiry into the interest of the prison population related to the motion for a new trial based on DNA analysis, with the determination of possibly legitimate requests and later proceedings. ]]></summary_en></project><project>
<id>12508</id><title_hr><![CDATA[Toll-like receptor 3 u razvoju i liječenju tumora glave i vrata: uloga endogenih liganada]]></title_hr><title_en><![CDATA[]]></title_en><user_id>12693</user_id><user_firstLast_name>Tanja Matijević Glavan</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-3254</code><acronim><![CDATA[TollTreatTum]]></acronim><duration>19.10.2021 - 18.10.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>855421</team_members_id><team_members_names><![CDATA[ Doktorand: Tea Vasiljević ]]></team_members_names><keywords_hr><![CDATA[tumori glave i vrata, Toll-like receptor 3, endogeni ligandi, matične stanice tumora, terapija tumora, ozračivanje, proteomika]]></keywords_hr><keywords_en><![CDATA[head and neck cancer, Toll-like receptor 3, endogenous ligands, cancer stem cells, tumor therapy, irradiation, proteomics]]></keywords_en><summary_hr><![CDATA[Toll-like receptori (TLR) su transmembranski proteini uključeni u pokretanje imunološkog odgovora. TLR mogu biti izraženi i na stanicama tumora gdje njihova uloga još nije do kraja razjašnjena. Aktivacija TLR3 pokreće se putem dsRNA podrijetlom od virusa ili sintetskim analogom (poly(I:C). TLR3 ima dvojnu ulogu u tumorima; njegovom aktivacijom pokreće se apoptoza, ali i i progresija tumora. U ovom ćemo projektu istraživati ulogu TLR3 u razvoju tumora s posebnim naglaskom na ulogu njegovih endogenih liganada. Ovi ligandi nastaju od nekrotičnih stanica tumora te mogu potaknuti progresiju raka. Istraživanja ćemo provoditi na nekoliko modela: a) reporterskoj liniji stanica za istraživanje TLR3 (HEK-Blue) gdje ćemo ispitivati hipotezu postojanja endogenih liganada za TLR3 dobivenih in vitro i in vivo iz nekrotičnog tkiva i stanica tumora, b) linijama stanica tumora glave i vrata stabilno transfeciranim sa shRNA za TLR3 i c) uzorcima tkiva izoliranih iz oboljelih od tumora glave. Drugi pristup uključivat će istraživanje uloge TLR3 i njegovih endogenih liganada u razvoju i samo-obnavljanju matičnih stanica tumora (CSC). Na kraju, pokušat ćemo razviti novu terapiju usmjerenu na CSC. Ove stanice pokazuju rezistenciju spram klasične terapije te mogu uzrokovati rekurenciju stoga je ciljanje ovih stanica razumna strategija u razvoju novih oblika terapija raka. Naš pristup uključivat će tretman s poly(I:C) i farmakološkim inhibitorima endogenih liganada u kombinaciji s ozračivanjem protonima ili gama-zrakama. Agonisti TLR3 već se istražuju kao potencijalni novi adjuvansi i pokretači apoptoze u liječenju tumora. Ovaj će se projekt fokusirati na donošenje novih spoznaja o dvojakoj ulozi TLR3 u tumorima i određivanju uvjeta pri kojima on djeluje pro-tumorski, a kada protu-tumorski. To je važno rasvijetliti prije uvođenja agonista TLR3 u kliničku praksu sa svrhom liječenja. ]]></summary_hr><summary_en><![CDATA[Toll-like receptors (TLRs) are transmembrane proteins involved in innate immune response. They can also be expressed on cancer cells where their role is still unresolved. TLR3 activation is triggered by dsRNA of viral origin or its synthetic analogue poly(I:C). TLR3 has a dual role in cancer; its activation triggers apoptosis as well as stimulates cancer progression. In this project we will explore the role of TLR3 activation in cancer development by focusing on the role of its endogenous ligands. These ligands originate from necrotic cancer cells and may stimulate cancer progression. We will study this on several models: a) TLR3 reporter cell line HEK-Blue to validate the in vivo and in vitro existence of TLR3 endogenous ligands derived from necrotic cells and tissue, b) head and neck cancer cell lines stably transfected with shRNA for TLR3 and c) cancer tissue specimens isolated from head and neck cancer patients. Second approach will include studying the role of TLR3 and its endogenous ligands in cancer stem cells (CSC) development and self-renewal. Lastly, we will seek to develop a novel anti-cancer therapy against CSC. These cells show resistance to classical therapy and may trigger recurrence thus targeting them is a reasonable strategy in cancer therapy development. Our approach will include combining proton or gamma-ray irradiation with the treatment with poly (I:C) and pharmacological inhibitors of endogenous ligands. TLR3 agonists are currently being investigated as potential novel cancer therapy adjuvants and apoptosis inducers. This project will focus on the delivery of new knowledge on the dual role of TLR3 in cancer and resolve the conditions in which TLR3 activation is either pro-tumorigenic or pro-apoptotic. It is of great importance to elucidate this before the introduction of TLR3 agonists into clinical practice.]]></summary_en></project><project>
<id>12509</id><title_hr><![CDATA[Analiza sustava u krizi i nove svijesti u književnosti 21. stoljeća]]></title_hr><title_en><![CDATA[]]></title_en><user_id>29129</user_id><user_firstLast_name>Sonja Novak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-5932</code><acronim><![CDATA[ASKiNS21]]></acronim><duration>04.10.2021 - 03.10.2025</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filologija, </scie_field_hr><scie_field_en>Philology, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>865091</team_members_id><team_members_names><![CDATA[ Doktorand: Marijana Mandić ]]></team_members_names><keywords_hr><![CDATA[sustav, mikro, makro, kriza, književnost, 21. stoljeće]]></keywords_hr><keywords_en><![CDATA[system, micro, macro, crisis, literature, 21st century,]]></keywords_en><summary_hr><![CDATA[Projekt polazi od hipoteze kako suvremena književnost (2000.-2020. godine) ima dominantno subverzivan odnos prema različitim sociokulturološkim sustavima kao što su obitelj, lokalna zajednica (npr. grad), država, regija (npr. Balkan, EU, Bliski Istok) i okoliš/planet te da se u suvremenim književnim tekstovima pri prikazivanju tih sustava vrlo često pojavljuju različite vrste krize, kako latentne, tako i manifestne. Ciljevi istraživanja su definirati korpus književnih djela nastalih u gorenavedenom periodu na njemačkom, engleskom i hrvatskom jeziku, usustaviti metodologiju njihove analize, i to transgenerički s obzirom na vrstu/podvrstu teksta, prostor i vrijeme radnje, karakterizaciju likova, mitski/utopijski ili distopijski potencijal, mehanizme prevladavanja krize, motivaciju radnje i analizu diskursa, uspostaviti bazu podataka vezanu uz korpus potpomognuto alatima za kvalitativnu analizu sadržaja te naposljetku testirati metodologiju na odabranim suvremenim tekstovima iz korpusa. ]]></summary_hr><summary_en><![CDATA[The hypothesis of the project is that contemporary literature (published 2000- until today)  predominantly exhibits a subversive attitude towards different sociocultural systems, such as e.g. family, local community (city or settlement), state, region (the EU, the Balkans, Middle East) and the environment/planet and that contemporary literary texts when depicting these systems often show them in a state of a latent or manifested crisis. The objectives of this research project are to  define a corpus of literary texts published in the 21st century in English, German and Croatian language, to systematize a transgeneric methodology for the analysis of these texts, with special emphasis on genre/sub genre, space, time, characterization, mythic, utopian or dystopian potential, coping mechanisms, motivating agents for the plot and discourse analysis. Another objective is to establish a database about the corpus of literary texts aided by tools for qualitative content analysis and to test this methodology on a number of selected contemporary literary texts.]]></summary_en></project><project>
<id>12510</id><title_hr><![CDATA[Imobilizacija lipaza na funkcionalizirane nosače na bazi odabranih otpada iz poljoprivredno-prehrambene industrije]]></title_hr><title_en><![CDATA[]]></title_en><user_id>333</user_id><user_firstLast_name>Ivica Strelec</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-7761</code><acronim><![CDATA[ImoLipWaste]]></acronim><duration>12.10.2021 - 11.10.2025</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Biotehnologija, </scie_field_hr><scie_field_en>Biotechnology, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Prehrambeno-tehnološki fakultet]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Food Technology]]></institution_en><team_members_id>864995</team_members_id><team_members_names><![CDATA[ Doktorand: Mirna Brekalo ]]></team_members_names><keywords_hr><![CDATA[lipaze, imobilizacija, otpad poljoprivredno-prehrambene industrije, ljuska jaja, talog kave, ljuska crvenog luka]]></keywords_hr><keywords_en><![CDATA[lipase, immobilization, agro-food industry waste, eggshell, spent coffee ground, brown onion skin]]></keywords_en><summary_hr><![CDATA[Jedan od glavnih izazova održivog gospodarenja otpadom poljoprivredno-prehrambene industrije je primjena strategije kružnog gospodarenja po „zero-waste“ modelu uz razvoj inovativnih tehnika transformacije otpada u koje se svakako može ubrojiti transformacija u nosače pogodne za imobilizaciju enzima. Zamjenom kemijskih katalizatora imobiliziranim enzimima moguće je riješiti otvorena pitanja energetske učinkovitosti i ekološke prihvatljivosti, dok ekonomska isplativost procesa ovisi o cijeni imobiliziranih enzima. Mogu li se transformacijom otpada dobiti cjenovno prihvatljivi nosači koji će poslužiti za imobilizaciju lipaza kako bi se razvile imobilizirane lipaze visoko-poželjnih svojstava koje bi se dugoročno mogle primijeniti u biokatalitičkoj proizvodnji je pitanje na koje se ovim istraživačkim projektom želi dobiti odgovor.U tu svrhu prvo će se provesti priprema nosača na bazi odabranog otpada: ljuske jaja, taloga kave i ljuske crvenog luka, kako bi se dobili nosači poželjnih operativnih svojstava i visokog kapaciteta imobilizacije. Nakon toga uslijedit će imobilizacija lipaza iz Pseudomonas fluorescens i Burkholderia cepacia različitim tehnikama imobilizacije, a sve u svrhu dobivanja imobiliziranih lipaza najpoželjnijih svojstava i visokog potencijala za primjenu u biokatalitičkim procesima. Određivanje ključnih biokemijskih i operativnih svojstava slobodnih i imobiliziranih lipaza poslužit će kao kriteriji odabira najuspješnijih, čija će se operativna funkcionalnost provjeriti u reakcijama hidrolize, acidolize i transesterifikacije. Tehno-ekonomska analiza simulacije u industrijskom mjerilu i analiza životnog ciklusa dat će krajnji odgovor koje će od imobiliziranih lipaza biti dugoročno najisplativije i ekološki najprihvatljivije.]]></summary_hr><summary_en><![CDATA[One of the main challenges of the agro-food industry sustainable waste management by “zero-waste” model is the application of the circular management strategy, including development of innovative waste transformation techniques. Agro-food waste transformation into carriers for enzyme immobilization clearly represent one of such techniques, while replacement of chemical catalysts with immobilized enzymes might solve the issues of energy efficiency and environmental acceptability. On the other hand, process economic cost-effectiveness is highly dependent on the immobilized enzyme price. Whether the agro-food waste transformation could result with cost effective enzyme carriers for lipase immobilization, and subsequent development of immobilised lipases of desirable operational properties for use in the biocatalytic production, is the question this project aiming to answer.In this respect, carriers of desirable operational properties and high immobilization capacity will be prepared from selected waste: eggshells, spent coffee grounds and brown onion skin followed by subsequent immobilization of Pseudomonas fluorescens i Burkholderia cepacia lipases using various immobilization techniques. Biochemical and operational properties of free and immobilized lipases will be used for the selection of developed immobilized lipases of the greatest efficiency, which will be tested for operational functionality in the selected reactions of acidolysis, hydrolysis and transesterification. The final proof will be confirmed by industrial scale techno-economic analysis simulation, as well as life cycle analysis.]]></summary_en></project><project>
<id>12512</id><title_hr><![CDATA[Dizajn katalitički aktivnih peptida i peptidnih nanostruktura]]></title_hr><title_en><![CDATA[]]></title_en><user_id>24626</user_id><user_firstLast_name>Daniela Kalafatovic</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-3496</code><acronim><![CDATA[DeShPet]]></acronim><duration>01.02.2022 - 01.08.2026</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Interdisciplinarno područje znanosti</scie_area_hr><scie_area_en>Interdisciplinary scientific area</scie_area_en><scie_field_hr>Biotehnologija u biomedicini, </scie_field_hr><scie_field_en>Biotechnology in Biomedicine, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Tehnički fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Engineering]]></institution_en><team_members_id>865282</team_members_id><team_members_names><![CDATA[ Doktorand: Marko Babić ]]></team_members_names><keywords_hr><![CDATA[Peptidi, samoorganizacija, kataliza, strojno učenje, modeli predviđanja, AFM, meki materijali]]></keywords_hr><keywords_en><![CDATA[Peptides, self-assembly, catalysis, machine learning, prediction models, AFM, soft materials]]></keywords_en><summary_hr><![CDATA[Područje umjetnih enzima u posljednje je vrijeme privuklo veliku pozornost istraživačke zajednice te su predloženi razni pristupi oponašanja bioloških katalizatora. Jedan od pristupa je stvaranje minimalističkih katalizatora na osnovi peptida i njihovih samoorganizirajućih nanostruktura. Peptidi su od velikog interesa u biomedicini zbog svoje inherentne bio-kompatibilnosti i biorazgradivosti, niske toksičnosti metabolita i zbog činjenice da su gradivni blokovi života. Poznato je da se kratki peptidi mogu samostalno organizirati u nano-strukture s različitim fizičkim i strukturnim karakteristikama, što često rezultira novim svojstvima i funkcijama koje nisu vidljive u njihovim monomerima, tj. sekvencama. Jedna takva funkcija je katalitička aktivnost. S druge strane, malo je poznato o principima koji reguliraju katalitičku aktivnost kratkih peptida, ali iz prethodnih istraživanja znamo da su i aminokiseline i njihov redoslijed unutar sekvence važni. U ovom projektu namjeravamo povezati strojno učenje i eksperimentalnu validaciju kako bi provedbu budućih eksperimenata učinili ciljanom, a time učinkovitijom i ekonomičnijom. U tu svrhu nastojati ćemo otkriti obrasce u postojećim podacima te ubrzati otkrivanje novih katalitičkih peptida kroz relativno mali broj eksperimenata. Sveobuhvatni cilj ovog projekta je odrediti možemo li uporabom strojnog učenja učinkovito predviđati katalitičku aktivnost kratkih peptida te otkriti ključne značajke koje upravljaju ovim procesom. U konačnici, želimo razumjeti kako određena peptidna sekvenca postiže katalitičku aktivnost te na koji se način željena funkcija može ostvarit kroz evoluciju sekvence u složenije (samoorganizirajuće i/ili tandemske) sustave. Upotrebom metodologije predložene ovim projektom želimo dati temelje za novu generaciju dizajna peptida, čija će se strategija moći proširiti na druge domene istraživanja kemijskog prostora te na nova otkrića.]]></summary_hr><summary_en><![CDATA[Artificial enzymes have attracted tremendous interest in recent years and several approaches to mimic biological catalysts have been proposed. One approach is to create minimalistic catalysts based on peptides and their assemblies. Peptides are increasingly investigated in biomedical applications due to their inherent biocompatibility, biodegradability, low toxicity of metabolites and because they are building blocks of life. Short peptides can self-assemble into nanostructures, which often results in new emerging functions, not observable with their constituting monomers. One such function is catalytic activity. Little is known about the principles that govern the catalytic activity of short peptides at the sequence level. From previous studies it is evident that the residues that make up the sequence and the order in which they appear are important. In this project, we want to combine machine learning with experimental validation to develop a more efficient and economical approach compared to the unguided experimental evaluation. We aim to discover patterns in existing data and accelerate the discovery of new catalytic peptides within a relatively small number of experiments. The overall objective is to determine whether we could use machine learning to efficiently predict the catalytic activity of short peptides and understand what are the key features that govern this process. We aim to reveal how are peptide sequences responsible for catalysis with the scope of evolving them to more complex systems, through self-assembly or tandem peptide repeats, to reach function. In our approach we aim to encompass the entire spectrum from fundamental understanding of peptide sequences and their ability to catalyze reactions to eventual societal benefit of discovering minimalistic versions of enzymes able to be used in every day life. The successful outcome of this project will result in a strategy able to explore broad sequence and structural spaces for future discoveries.]]></summary_en></project><project>
<id>12514</id><title_hr><![CDATA[PRirodA kao SAVEZnik: Strane  biljne invazivne vrste kao izvor farmaceutika  ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6513</user_id><user_firstLast_name>Danijela Poljuha</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-3094</code><acronim><![CDATA[NATURALLY]]></acronim><duration>01.09.2021 - 31.08.2025</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Interdisciplinarne biotehničke znanosti, </scie_field_hr><scie_field_en>Interdisciplinary biotechnical sciences, </scie_field_en><institution_hr><![CDATA[Institut za poljoprivredu i turizam]]></institution_hr><institution_en><![CDATA[Institute of Agriculture and Tourism in Poreč]]></institution_en><team_members_id>865029</team_members_id><team_members_names><![CDATA[ Doktorand: Mirela Uzelac Uzelac ]]></team_members_names><keywords_hr><![CDATA[strane invazivne vrste, biljke, ekstrakti, fitofarmaceutici, fenolni profil, biološka aktivnost, usluge ekosustava]]></keywords_hr><keywords_en><![CDATA[invasive alien species, plants, extracts, phytopharmaceuticals, phenolic profile, biological activity, ecosystem services]]></keywords_en><summary_hr><![CDATA[Ekstrakti mnogih biljnih vrsta sadrže značajne bioaktivne spojeve, stoga bi uporaba odgovarajućih biljnih ekstrakata mogla dovesti do razvoja novih, jeftinih i ekološki prihvatljivih farmaceutskih proizvoda baziranih na lokalnim prirodnim izvorima. Invazivne vrste predstavljaju jednu od najvećih  globalnih prijetnji bioraznolikosti. Introducirane vrste mogu postati invazivne i potisnuti autohtone vrste, utjecati na procese i funkcioniranje ekosustava, ometati pružanje usluga ekosustava te uzrokovati značajne ekonomske gubitke. Međutim, i domaće i introducirane vrste imaju značajnu društvenu, gospodarsku, krajobraznu i ekološku vrijednost i pružaju niz usluga ekosustava. Potencijal invazivnih biljnih vrsta je osim njihove moguće uporabe kao izvora farmaceutski aktivnih spojeva i u njihovoj dostupnosti u velikim količinama. Glavni cilj ovog projekta je istražiti fitofarmaceutski potencijal prirodnih ekstrakata četiri strane invazivne biljne vrste (SIBV) u Istri (Hrvatska), kao osnovu za nove moguće usluge ekosustava. To se planira postići ostvarivanjem sljedećih specifičnih ciljeva: kemijsko profiliranje ekstrakata SIB vrsta tekućinskom kromatografijom – spektrometrijom mase (LC-MS); određivanje antioksidacijskih, antimikrobnih, antiproliferativnih, genotoksičnih i citotoksičnih svojstava ekstrakata SIB vrsta i izoliranih specifičnih frakcija funkcionalnim testovima; procjena potencijala SIB vrsta za primjenu u fitofarmaciji; prijedlog modela za iskorištavanje novih (medicinskih) usluga ekosustava koje pružaju SIB vrste na pilot području Istre (Hrvatska). Projekt će stvoriti nova znanja vezana uz biofarmaceutski potencijal SIB vrsta, što će potencijalno pridonijeti razvoju hrvatskog bioekonomskog sektora, kao i globalnom zdravlju i kvaliteti života. Uz to, kroz realizaciju projekta uspostavit će se nove suradnje između nacionalnih i međunarodnih istraživačkih timova.]]></summary_hr><summary_en><![CDATA[Extracts of many plant species have substantial bioactive compounds; therefore the use of plant extracts with good activity could lead to the development of new inexpensive and environmentally acceptable pharmaceutical products based on locally available natural resources. Invasive species are recognized as one of the largest global threats to biodiversity. Introduced species may become invasive and displace native species, affect ecosystem processes and functioning, and cause substantial economic losses. On the other hand, both native and non-native species have enormous social, economic, landscape, and ecological importance and provide a number of ecosystem services. The potential of invasive species is in their possible use as a source of pharmaceutically active compounds, and also in their availability in large quantities. The general objective of this project is to explore the potential of natural extracts of four most widespread alien invasive plant species (IAPS) in Istria (Croatia) for the application as phytopharmaceuticals, as a basis for a new possible ecosystem service provided by IAPS. It will be accomplished through the achievement of the following specific objectives: chemical profiling of IAPS extracts by liquid chromatography–mass spectrometry (LC-MS); determination of antioxidative, antimicrobial, antiproliferative, genotoxic and cytotoxic properties of IAPS extracts and isolated specific fractions by functional tests; the estimation the IAPS potential for the application in phytopharmacy; the proposal of the model for exploring new IAPS provisioning (medicinal) ecosystem services on the pilot territory of Istria (Croatia). The project will create new knowledge related to biopharmaceutical potential of IAPS, which will potentially contribute to the development of Croatian bio-economy sector as well as global health and quality of life. Moreover, new connections between national and international research teams will be established.]]></summary_en></project><project>
<id>12515</id><title_hr><![CDATA[Model demijelinizacije na molekulskoj skali pri fiziološkim i patološkim uvjetima]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5002</user_id><user_firstLast_name>Danijela Bakarić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-5341</code><acronim><![CDATA[DEMYMOLSCALE]]></acronim><duration>17.01.2022 - 16.01.2026</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>855428</team_members_id><team_members_names><![CDATA[ Doktorand: Lea Pašalić Pašalić ]]></team_members_names><keywords_hr><![CDATA[demijelinizacija, lipidne membrane, mijelin-bazični protein, fosfatidiletanolamin, inverzna heksagonska faza, FTIR spektroskopija, računalna kemija]]></keywords_hr><keywords_en><![CDATA[demyelination, lipid membranes, myelin basic protein, phosphatidylethanolamine, inverse hexagonal phase, FTIR spectroscopy, computational chemistry]]></keywords_en><summary_hr><![CDATA[Mijelin je višestruko-dvoslojna, pretežno lipidna ovojnica koja omata aksone i osigurava pravilan prijenos živčanih impulsa. Gubitak cjelovitosti mijelina u obliku njegovog prekomjernog odmotavanja, stvaranja vakuola te bubrenja dvosloja naziva se demijelinizacijom koja je povezana s multiplom sklerozom (MS). In vivo studije provedene na oboljelim životinjama pokazale su da su količine najzastupljenijih lipida, uključujući fosfatidiletanolamine (PE), značajno promijenjene u usporedbi sa zdravima, a prati ih i smanjena adhezivna aktivnost mijelin-bazičnog proteina (MBP). Utjecaj povećanja PE u mješovitim modelnim lipidnim membranama na temperaturu faznog prijelaza iz lamelarne (La) u inverznu heksagonsku (HII) fazu, koji pokazuje strukturne sličnosti s formiranjem vakuola, značajan je, ali prilično nedokučiv problem. Cilj ovog prijedloga je naći vezu između spomenute temperaturne promjene te veličine i rasporeda PE-domena u mješovitim modelnim lipidnim membranama uz i bez prisustva MBP-a. Modelne mijelinske membrane priredit će se iz najzastupljenijih mijelinskih lipida u skladu s njihovim omjerima u normalnim i oboljelim jedinkama. Uz različito okruženje PE domena unutar dvosloja, zajedno s promjenama u hidratacijskom mediju u pogledu prisustva MBP-a te ionskog sadržaja, sustavno će se proučiti promjene temperature La do HII faznog prijelaza PE domena. Detaljna molekularna slika tih događaja dobit će se kombinacijom temperaturno-ovisne IR spektroskopije i računalne kemije; strukturne promjene PE domena tijekom ove fazne promjene otkrit će se zajedno s interakcijama između PE, MBP i susjednih domena. Odredit će se parametri koji se smatraju najkritičnijima u smanjenju temperature faznog prijelaza La do HII. Osim razumijevanja demijelinizacije na molekularnoj razini, dobiveni rezultati će također pomoći u predlaganju mogućih rješenja u regulaciji lipidnog sastava lijekovima te odgovarajućom prehranom.]]></summary_hr><summary_en><![CDATA[Myelin is multibilayered, dominantly lipid sheath that enwraps axons and ensures proper transmission of neural impulses. Loss of myelin integrity in terms of redundant unwrapping, vacuole formation and swelling of the bilayer sheaths is referred as demyelination and is related to multiple sclerosis. In vivo studies reported that the amounts of representative lipids, including phosphatidylethanolamines (PEs), are significantly changed in diseased compared to healthy animals, and are further accompanied by reduced adhesive activity of myelin basic protein (MBP). The impact of the amount of PE in mixed model lipid membranes on the transition temperature between lamellar (La) to inverse hexagonal (HII) phase, where the latter shares structural features with vacuole formation, is significant but rather elusive issue. The aim of this proposal is to establish a link between this temperature change and the size and arrangement of PE domains in mixed model lipid membranes in the presence and absence of MBP. Model myelin membranes will be prepared from representative myelin lipids according to their ratios found in normal and diseased species. La to HII phase transitions of PE domains will be studied by probing different surroundings of PE domains within the bilayer, along with the variations in the hydrating medium regarding the presence of MBP and ionic content. A detailed molecular picture of these events will be provided by combining temperature-dependent IR spectroscopy and computational chemistry; structural changes of PE domain during this phase transition will be identified together with the interactions between PE, MBP and neighboring domains. As a result, the parameters considered as the most critical in reduction of La to HII phase transition temperature will be revealed. Aside of understanding demyelination at the molecular level, obtained results will help in suggesting possible solutions in lipid composition regulation by medications and appropriate nutrition.]]></summary_en></project><project>
<id>12516</id><title_hr><![CDATA[Predobro da bi bilo istinito? Učinak turizma na tržište nekretnina u Hrvatskoj]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3373</user_id><user_firstLast_name>Anita Čeh Časni</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-2311</code><acronim><![CDATA[TOURCRO]]></acronim><duration>13.12.2021 - 13.12.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, </scie_field_hr><scie_field_en>Economy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Ekonomski fakultet u Zagrebu]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Economics and Business]]></institution_en><team_members_id>865153</team_members_id><team_members_names><![CDATA[ Doktorand: Josipa Filić ]]></team_members_names><keywords_hr><![CDATA[cijene rezidencijalnih nekretnina, cijene građevinskog zemljišta, turistička aktivnost, turističke eksternalije, peer-to-peer platforme, prelijevanja]]></keywords_hr><keywords_en><![CDATA[housing prices, building plot prices, tourism activity, tourism externalities, peer-to-peer platforms, regional spillovers]]></keywords_en><summary_hr><![CDATA[Cilj ovog projekta jest istražiti utjecaj turističke aktivnosti na cijene nekretnina, što je tema od rastuće društvene i ekonomske važnosti koja je nedovoljno istražena u literaturi. Fokusirali smo se na Hrvatsku, malu otvorenu ekonomiju koja uvelike ovisi o prihodima od turizma, s turističkom industrijom koja se dominantno temelji na kratkoročnom najmu smještaja, kako bismo istražili utjecaj promjene turističke orijentacije u hrvatskim jedinicama lokalne samouprave (JLS) na cijene apartmana, obiteljskih kuća i građevinskih zemljišta. Budući da je Hrvatska relativno mala zemlja u kojoj je otprilike jedna trećina lokalnih jedinica orijentirana na turističke usluge, dok ostale jedinice lokalne samouprave nemaju izravnu izloženost turizmu, istražujemo karakteristike i modalitete prostornog prelijevanja cijena stanova i cijena obiteljskih kuća u svim jedinicama lokalne samouprave koje su posljedica promjena u turističkoj aktivnosti. Osim toga, zbog svoje povijesne ovisnosti o kratkoročnom najmu smještaja, Hrvatska je idealno područje za procjenu kako promjena ponude turističkog smještaja prema većoj dominaciji privatnih kratkoročnih iznajmljivanja putem digitalnih peer-to-peer platformi utječe na cijene stanova i cijene kuća. Konačno, ispitujemo imaju li vanjski utjecaji na okoliš, koji se mogu pripisati turističkoj aktivnosti, utjecaj na cijene stanova i obiteljskih kuća u hrvatskim jedinicama lokalne samouprave. Kako bismo ostvarili ove ciljeve, konstruirali smo sveobuhvatnu godišnju bazu podataka koja sadrži podatke za svih 557 hrvatskih gradova i općina od 2012. godine do danas, na koju ćemo primijeniti dinamičke i prostorne procjene panel podataka u kombinaciji s hedonističkim cjenovnim modelima. Baza podataka obuhvaća pokazatelje tržišta nekretnina (uključujući medijalnu cijenu stanova, obiteljskih kuća i apartmana), različite pokazatelje turističke aktivnosti i standardne odrednice ponude i potražnje cijena nekretnina.]]></summary_hr><summary_en><![CDATA[The aim of this project is to investigate the impact tourism activity exerts on house prices; a topic with increasing social and economic relevance which thus far has been scarcely addressed in the literature. We focus on Croatia, a small open economy highly dependent on tourism revenues with a tourism industry based dominantly on short-term rental accommodation, in order to investigate how changes in tourism orientation in Croatian local government units (LGUs) influences the prices of apartments, family houses, and building plots. Since Croatia is a relatively small country in which approximately one third of LGUs are oriented toward tourism services, while the rest of LGUs have no direct exposure to tourism, we explore the characteristics and modalities of spatial spillovers of apartments and family houses price across all LGUs due to changes in tourism activity. In addition, due to its historic dependence on short-term rental accommodation, Croatia is an ideal laboratory to assess how the change of the tourist accommodation supply towards the dominance of private short-term rentals offered through digital peer-to-peer platforms affects apartment and house prices. Lastly, we examine whether environmental externalities that can be attributed to tourism activity exhibit an impact on apartment and family house prices in Croatian LGUs. In order to achieve these tasks we build a comprehensive annual database containing data for all 557 Croatian cities and municipalities from 2012 to present, and apply dynamic and spatial panel data estimation methods coupled with hedonic price models. The database encompasses housing market indicators (including median prices of apartments, family houses and apartments), various indicators of tourism activity and standard supply- and demand-side determinants of house prices. ]]></summary_en></project><project>
<id>12519</id><title_hr><![CDATA[H2020 MESOC Measuring the Social Dimension of Culture]]></title_hr><title_en><![CDATA[]]></title_en><user_id>659</user_id><user_firstLast_name>Sanda Martinčić-Ipšić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-1867</code><acronim><![CDATA[]]></acronim><duration>05.10.2023 - 04.10.2026</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Informacijske znanosti, </scie_field_hr><scie_field_en>Information sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci]]></institution_hr><institution_en><![CDATA[University of Rijeka]]></institution_en><team_members_id>867559</team_members_id><team_members_names><![CDATA[ Doktorand: Andrija Poleksić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>12521</id><title_hr><![CDATA[Fizikalna kemija procesa na međupovršini mineral/otopina (poli)elektrolita]]></title_hr><title_en><![CDATA[]]></title_en><user_id>244</user_id><user_firstLast_name>Tajana Begović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-5279</code><acronim><![CDATA[POLYMIN2]]></acronim><duration>15.10.2021 - 20.10.2026</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>865139</team_members_id><team_members_names><![CDATA[ Doktorand: Karla Korade ]]></team_members_names><keywords_hr><![CDATA[minerali, polielektroliti, međupovršine, površinske reakcije, adsorpcija, električni međupovršinski sloj]]></keywords_hr><keywords_en><![CDATA[minerals, polyelectrolytes, interfaces, surface reactions, adsorption, electrical interfacial layer]]></keywords_en><summary_hr><![CDATA[Razumijevanje procesa na površinama minerala suspendiranih u vodenim otopinama elektrolita i polielektrolita važno je za razvijanje teorijskih modela, ali i za brojne primjene. Procesi na površinama često su složeni i međuovisni, a u sklopu ovog projekta primjenom eksperimentalnih metoda i teorijskih modela proučavat će se procesi na površini, u otopini i njihov međusobni utjecaj. Istražit će se procesi na površinama odabranih minerala (TiO2, SiO2 i CaF2) i površinama ovih minerala prekrivenih polielektrolitima različitom kemijskog sastava i različitih gustoća naboja. Kalorimetrijskim, potenciometrijskim, elektrokinetičkim i elektrokemijskim metodama ispitat će se utjecaj ionske jakosti i sastava otopine na površinske reakcije. Primjenjivost eksperimentalnih tehnika povećat će se sparivanjem različitih eksperimentalnih metoda. Istražit će se utjecaj adsorbiranih polielektrolita na svojstva električki nabijenih površina minerala i nanočestica. Koloidna stabilnost suspenzija koje sadrže ispitivane minerale usporedit će se s koloidnom stabilnošću minerala prekrivenih polielektrolitima. Ispitat će se kemijska reaktivnost i otapanje minerala prekrivenih polielektrolitima. Ova istraživanja uključuju razvoj modela koji opisuje stanje na površini i utjecaj adsorpcije polielektrolita na reakcije na površini. Materijali (minerali i makromolekule) birani su temeljem njihove bioaktivnosti i biokompatibilnih svojstava. Uzevši u obzir uporabu predloženih minerala u industriji hrane, kozmetičkoj i farmaceutskoj industriji, rezultati projektnih istraživanja mogli bi imati i široku primjenu u navedenim područjima djelatnosti. ]]></summary_hr><summary_en><![CDATA[Understanding the processes occurring at mineral surfaces exposed to aqueous electrolyte and polyelectrolyte solutions is important from the fundamental point of view but also for numerous possible applications. Processes at mineral surfaces are often complex and interdependent. Within the proposed project the phenomena taking place at surfaces, in solution, and their interplay will be studied using experimental methods and applying theoretical models. The selected minerals (TiO2, SiO2 and CaF2) and the surfaces of these minerals covered with polyelectrolytes of different composition, charge and charge densities will be investigated. The chemical stability of the mineral surfaces and the surface dissolution will be studied. The influence of ionic strength and solution composition on aforementioned processes will be investigated by calorimetric, potentiometric, electrokinetic and electrochemical methods. One of the objectives of the project is to couple different experimental methods in order to simultaneously measure different parameters that characterize surface reactions. The influence of the adsorbed polyelectrolytes on surface reactions and properties of electrically charged minerals will be explored. A model which describes surface equilibrium states and the effect of polyelectrolyte adsorption on transformation and dissolution of the mineral will be proposed. Importantly, materials (minerals and macromolecules) which will be investigated were selected on the basis on their bioactivity and biocompatibility. This is due to their frequent use in food, cosmetic and pharmaceutical industry, which opens a path for numerous possible applications of results obtained within the frame of proposed project research.]]></summary_en></project><project>
<id>12522</id><title_hr><![CDATA[Pharmaceutical Open Innovation Test Bed for Enabling Nano-pharmaceutical Innovative Products – PHOENIX]]></title_hr><title_en><![CDATA[]]></title_en><user_id>573</user_id><user_firstLast_name>Ivana Vinković Vrček</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-4858</code><acronim><![CDATA[]]></acronim><duration>13.09.2021 - 12.09.2025</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Interdisciplinarno područje znanosti</scie_area_hr><scie_area_en>Interdisciplinary scientific area</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut za medicinska istraživanja i medicinu rada]]></institution_hr><institution_en><![CDATA[Institute for Medical Research and Occupational Health]]></institution_en><team_members_id>865025</team_members_id><team_members_names><![CDATA[ Doktorand: Nikolina Peranić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>12523</id><title_hr><![CDATA[Prirodni bioaktivni spojevi kao izvor potencijalnih antimikrobnih tvari u suzbijanju bakterijskih i drugih gljivičnih patogena masline]]></title_hr><title_en><![CDATA[]]></title_en><user_id>18945</user_id><user_firstLast_name>Sara Godena</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-2882</code><acronim><![CDATA[Anti-Mikrobi-OL]]></acronim><duration>23.08.2021 - 22.08.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Institut za poljoprivredu i turizam]]></institution_hr><institution_en><![CDATA[Institute of Agriculture and Tourism in Poreč]]></institution_en><team_members_id>865016</team_members_id><team_members_names><![CDATA[ Doktorand: Elena Petrović ]]></team_members_names><keywords_hr><![CDATA[antimikrobno djelovanje, biljna voda, eterična ulja, Olea europaea L., Pseudomonas savastanoi pv. savastanoi, test patogenosti]]></keywords_hr><keywords_en><![CDATA[antimicrobial activity, vegetable water, essential oils, Olea europaea L., Pseudomonas savastanoi pv. savastanoi, pathogenicity test]]></keywords_en><summary_hr><![CDATA[U istraživanju će se na području Hrvatske, Slovenije, Bosne i Hercegovine te Portugala utvrditi prisutnost bakterijskog raka i manje poznatih patogenih gljiva masline. Nakon identifikacije patogena molekularnim metodama, provesti će se test patogenosti. Budući da nema podataka o osjetljivosti hrvatskih sorti masline na rak masline, utvrditi one sorte koje su rezistentnije. Utvrditi će se i antimikrobno djelovanje kompleksnih bioaktivnih sastojaka u sastavu biljne vode i eteričnih ulja visoke kakvoće. Ispitati će se inhibicija rasta mikroorganizama in vitro i in vivo, a utvrditi će se kemijski profil za mikrobiološki aktivne sekundarne metabolite. Važnost ovog istraživanja ogledati će se kroz moguće rješenje fitopatološkog problema: budući da ne postoji adekvatna kurativa, javlja se nužnost za pronalaskom alternativnih i djelotvornih spojeva. Istraživanja o takvim spojevima nisu izrazito zastupljena iako prema literaturi postoje više od 1 340 biljaka koje su potencijalni izvor ovih spojeva. Ovi djelotvorni i neopasni spojevi predstavljaju potencijalno rješenje za problematiku u fitomedicini, odgovor su na sve ugroženije zdravlje ljudi i mogle bi smanjiti primjenu toksičnih sintetičkih pesticida. Ovim se projektom želi nastaviti daljnji rad prijašnjih istraživanja, gdje je dokazano povećanje sadržaja ukupnih fenola u zaraženim maslinama i gdje su utvrđene neke manje poznate patogene gljive. Očekuje se da će bioaktivne tvari imati velik antimikrobni učinak, da će se pronaći i način njihove primjene, a primjenom bi se tih tvari mogao riješiti i problem ekološkog zbrinjavanja biljne vode, koja nastaje kao nusproizvod i kao takva predstavlja ekološki problem. Očekuje se rast interesa za tim spojevima, a kako bi se procijenile potencijalne doze i način aplikacije, potrebna su daljnja i uzastopna istraživanja.]]></summary_hr><summary_en><![CDATA[The study will determine the presence of olive knot and less known pathogenic fungi of olive in Croatia, Slovenia, Bosnia and Herzegovina and Portugal. After confirmation of pathogen identification by molecular methods, a pathogenicity test will be performed. Since there is no information on the susceptibility of Croatian varieties to olive knot, varieties which are more resistant will be determined. Antimicrobial activity of complex bioactive constituents in the composition of vegetable water (OMWW) and high quality essential oils will be determined. The inhibition of growth of microorganisms in vitro and in vivo will be tested and the chemical profile of the microbiologically active secondary metabolites will be determined. The importance of this research will be reflected in a possible solution of phytopathological problem: since there is no adequate cure, there is a need to find alternative and effective compounds. Studies of such compounds are not pronouncedly represented in scientific databases, although there are more than 1340 plants as potential source of such compounds. These effective and non-hazardous compounds represent a potential solution to the phytomedicine problem, are an answer to the increasingly threatened human health and could reduce the use of toxic synthetic pesticides. This project aims to continue further work of previous research, where an increase in the content of total phenols in infected olives has been demonstrated, and where some less known pathogenic fungi have been identified. It is expected that bioactive substances will have a great antimicrobial effect, that method of their application will be found and that their use could also solve the problem of ecological disposal of OMWW, which originated as a by-product and presents an environmental problem as such. It is expected to increase the interest in these compounds, and to evaluate potential doses and mode of application further and sequential studies are needed.]]></summary_en></project><project>
<id>12524</id><title_hr><![CDATA[Inovativna lagana međukatna konstrukcija – spregnuti sustav hladno oblikovani čelik i beton]]></title_hr><title_en><![CDATA[]]></title_en><user_id>21350</user_id><user_firstLast_name>Ivan Ćurković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-2373</code><acronim><![CDATA[LWT-FLOOR]]></acronim><duration>17.11.2021 - 16.11.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Građevinarstvo, </scie_field_hr><scie_field_en>Civil engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Građevinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Civil Engineering]]></institution_en><team_members_id>865232</team_members_id><team_members_names><![CDATA[ Doktorand: Vlaho Žuvelek ]]></team_members_names><keywords_hr><![CDATA[točkasto zavarivanje, međukatna konstrukcija, posmična veza, sastavljeni, mogućnost ponovne uporabe, probabilistički pristup, analiza životnog ciklusa]]></keywords_hr><keywords_en><![CDATA[spot welding, composite floor system, shear connection, built-up, reusability, probabilistic aproaches, lifecycle analysis]]></keywords_en><summary_hr><![CDATA[Projekt LWT-FLOOR povezuje najnovije spoznaje u novoj, brzoj i produktivnoj tehnologiji točkastog zavarivanja i inovativna rješenja sprezanja hladno oblikovanog čelika i betona predlažući novu metodu izgradnje kao kombinaciju sastavljenih hladno oblikovanih čeličnih elemenata i betonske ploče. Ovaj ekonomičan i održiv sustav lagane međukatne konstrukcije nudi vitalne prednosti u smislu visokog stupnja predgotovljenosti, mogućnosti ponovne upotrebe i mogućih velikih raspona. Glavni cilj projekta je uspostaviti novu istraživačku grupu koja će posjedovati znanje i opremu za istraživanje novog sustava međukatne konstrukcije s fokusiranim znanstvenim interesima u potrazi za konkurentnijim nacionalnim i međunarodnim financiranjem. Kako bi se istražile i vrednovale komponente i predloženi sustav u cjelini, planira se opsežno eksperimentalno, numeričko i probabilističko istraživanje. U okviru istraživanja posebna pozornost će biti posvećena točkastim zavarima i inovativnim vrstama posmične veze s mogućnošću projektiranja za demontažu i potencijalom za buduće ponovne uporabe ili recikliranja na kraju životnog vijeka uključujući primjenu analize životnog ciklusa. Kalibrirani numerički modeli temeljeni na eksperimentalnim ispitivanjima sustava i njegovih komponenata omogućit će, uz primjenu probabilističkih metoda, procjenu prikladnosti sustava za veće raspone. Projekt će donijeti nove vještine istraživačkoj grupi i istraživačkoj instituciji, a pored toga obranit će se i dvije disertacije te objaviti znanstveni radovi u najcitiranijim časopisima. Ovaj inovativni projekt, koji osigurava čvrste veze između akademske zajednice i industrije, povećat će mobilnost i ojačati dugoročnu suradnju između dva sektora. Probabilističke analize i procjene ponašanja predloženog rješenja u životnom ciklusu međukatne konstrukcije bit će od ključnog značaja za pripremu prvog analitičkog prijedloga za izradu preporuka za projektiranje ovog novog sustava u okviru europskih norma.]]></summary_hr><summary_en><![CDATA[The LWT-FLOOR project integrates state-of-the-art knowledge in new, fast and productive spot-welding technology and innovative cold-formed steel-concrete composite solutions proposing a new construction method as a combination of built-up cold-formed steel members and cast-in-place concrete slab. This cost-effective and sustainable floor system offers vital benefits in terms of a high degree of prefabrication, reusability and long spanning capability. The main objective of the project is to establish a new research group that will possess knowledge and equipment for research on new composite floor system with focused scientific interests in a search for more competitive national and international funding. In order to investigate and validate components and proposed system, the extensive experimental, numerical and probabilistic research is planned. Within research, a particular focus will be given to spot-welding connections and innovative types of shear connections with possibility of design for demountability and the potential of re-use or recycling at the end of design life through the application of lifecycle analyses. Calibrated and validated numerical models based on experimental tests of the system and its components will allow, through the application of probabilistic methods, evaluation of the system suitability for larger spans. The project will bring out new skills to the research group and the research institution, besides which two dissertations will be defended and scientific papers in most cited journals will be published. This innovative project, providing strong connections between the scientific community and industry, will increase the mobility as well as strengthen long-term cooperation between the two sectors. Probabilistic analyses and life cycle performance evaluation of the proposed floor system solution will be crucial for establishing the first analytical proposal for design recommendations of this new system within the European standards.]]></summary_en></project><project>
<id>12525</id><title_hr><![CDATA[ABsistemDCiCloud]]></title_hr><title_en><![CDATA[]]></title_en><user_id>21407</user_id><user_firstLast_name>Jonatan Lerga</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-3306</code><acronim><![CDATA[]]></acronim><duration>01.12.2021 - 30.11.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Tehnički fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Engineering]]></institution_en><team_members_id>865241</team_members_id><team_members_names><![CDATA[ Doktorand: Anna Maria Mihel ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>12526</id><title_hr><![CDATA[Cementni kompoziti ojačani otpadnim vlaknima]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5060</user_id><user_firstLast_name>Ana Baričević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-4884</code><acronim><![CDATA[ReWire]]></acronim><duration>01.10.2021 - 30.09.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Temeljne tehničke znanosti, </scie_field_hr><scie_field_en>Basic engineering sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Građevinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Civil Engineering]]></institution_en><team_members_id>865113</team_members_id><team_members_names><![CDATA[ Doktorand: Branka Mrduljaš ]]></team_members_names><keywords_hr><![CDATA[otpadna vlakna, hibridni mikroarmirani kompoziti, raspodjela vlakana, sučeljak, trajnost, LCA]]></keywords_hr><keywords_en><![CDATA[waste fibres, hybrid fiber reinforced composites, distribution of fibers, ITZ,  durability, LCA]]></keywords_en><summary_hr><![CDATA[Građevinska industrija je najveći svjetski potrošač prirodnih resursa i odgovorna je za 25-40% globalne emisije ugljičnog dioksida. Stoga su potrebni zajednički napori za promicanje prelaska na gospodarstvo s niskim ekološkim otiskom, koje je klimatsko neutralno, a resursi učinkoviti i kružni. ReWire projekt će doprinijeti prijeko potrebnoj promjeni paradigme u razvoju inženjerskih rješenja razvojem učinkovitih cementnih materijala ojačanih lokalno dostupnim otpadnim vlaknima, uz razumijevanje njihovog dugoročnog utjecaja na okoliš i cjeloživotne troškove građevine. Osim osnivanja autonomne istraživačke skupine koja je nužna za konkurentno sudjelovanje Hrvatske u ovom istraživačkom području, kroz ReWire projekt će se unaprijedit tehnologije primjene visokovrijednih otpadnih vlakana i razviti znanstveni okvir za njihovu uporabu u građevinskom sektoru. Projektom se analizira primjena recikliranih polimernih vlakana iz otpadnih guma te ugljičnih, staklenih i bazaltnih otpadnih vlakana iz proizvodnje visokovrijednih tkanina za građevinarstvo, a sve za ojačanje cementnih kompozita. Ciljevi ReWire projekta su: a) osnivanje istraživačke skupine kao centra znanja za istraživanje, razumijevanje i modeliranje cementnih kompozita ojačanih otpadnim vlaknima, b) povezivanje znanstvenih organizacija, istraživača i opreme kroz regionalnu mrežu te c) usavršavanje istraživačke skupine u istaknutim međunarodnim centrima u istraživačkom području.]]></summary_hr><summary_en><![CDATA[Construction industry is the world largest consumer of natural materials and is responsible for 25-40% of global carbon emissions. Therefore, concerted effort is required to promote a transition towards a low-carbon economy that is climate neutral, resource-efficient and circular. The ReWire project will contribute to the much-needed paradigm shift in the development of engineering solutions. Development of highly effective cementitious materials reinforced with locally available waste fibres will be done, along with a deep understanding of their long-term environmental impacts and the life-cycle costs. Whilst addressing the need to establish an internationally recognized research group to keep Croatia competitively participating in this new research area, the technologies for waste fibre application will be enhanced. This will reduce the disposal of high value materials and develop the scientific background for their application in construction sector. Use of recycled tire polymer fibres & carbon, glass and basalt waste fibres, from the production of high-performance construction textiles, in fibre reinforced cementitious composites will be analysed. ReWire aims to: a) establish new research group as a centre of knowledge for the research, understanding and modelling of cementitious composites reinforced with waste fibres; b) connect scientific organizations, researchers and equipment through a regional network; and c) train research group by international centres recognized in the research field.]]></summary_en></project><project>
<id>12527</id><title_hr><![CDATA[Fenotipski odgovor provenijencija obične bukve i hrasta kitnjaka na dugotrajnu sušu u interakciji s različitom koncentracijom fosfora u tlu]]></title_hr><title_en><![CDATA[]]></title_en><user_id>11167</user_id><user_firstLast_name>Krunoslav Sever</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-5560</code><acronim><![CDATA[PhenoInter]]></acronim><duration>08.11.2021 - 07.11.2025</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Šumarstvo, </scie_field_hr><scie_field_en>Forestry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet šumarstva i drvne tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Forestry and Wood Technology]]></institution_en><team_members_id>865175</team_members_id><team_members_names><![CDATA[ Doktorand: Antonia Vukmirović ]]></team_members_names><keywords_hr><![CDATA[obična bukva, hrast kitnjak, provenijencija, sušni stres, fosfor]]></keywords_hr><keywords_en><![CDATA[common beech, sessile oak, provenance, drought stress, phosphorus ]]></keywords_en><summary_hr><![CDATA[Pod utjecajem klimatskih promjena na području Europe u posljednje vrijeme dolazi do ometanja uredne ishrane šumskoga drveća s fosforom (P). S druge strane, adekvatna ishranjenost šumskog drveća s P mogla bi ublažiti negativne posljedice sušnoga stresa i podići njegovu toleranciju prema suši. Ta pretpostavka temelji se na fiziološkoj ulozi P koji regulira fotosintezu i glikolizu te kontrolira asimilaciju CO2 i produkciju biomase. Obična bukva i hrast kitnjak diljem Europe tvore mješovite šumske zajednice koje pridolaze na suhim i vlažnim staništima čija se tla nerijetko odlikuju različitom koncentracijom P. Genetska raznolikost hrasta kitnjaka i obične bukve na području jugoistočne Europe (kamo spada i Republika Hrvatska) kao i njihova unutarvrsna adaptivna varijacija u odgovoru na sušni stres do sada je vrlo rijetko istraživana. Uz to, postojanje eventualnih interakcija između različitih genotipova (provenijencija obične bukve i/ili hrasta kitnjaka) izloženih sušnom stresu pri različitim koncentracijama P u tlu još uvijek predstavlja nepoznanicu koja će se pokušati rasvijetliti ovim projektom. Prema tome, primarni ciljevi ovoga projekta su: (1) utvrditi utjecaj povišene koncentracije P u tlu na toleranciju obične bukve i hrasta kitnjaka prema sušnom stresu, (2) utvrditi postojanje lokalne adaptiranosti provenijencija obične bukve i hrasta kitnjaka na sušni stres, kao i genotipskih razlika u toleranciji na sušu pod utjecajem povišene koncentracije P u tlu i (3) utvrditi postojanje tzv. memorijskih efekata (after efekata) nakon pretrpljenog sušnog stresa kod obične bukve i hrasta kitnjaka, odnosno utjecaj povišene koncentracije P u tlu na takve efekte. Važnost ovoga projekta ogleda se u doprinosu njegovih rezultata podržavanju gospodarskih i općekorisnih funkcija šuma što bi se moglo pozitivno odraziti na dobrobit čitavoga društva, gospodarstva i struke.]]></summary_hr><summary_en><![CDATA[Under the influence of climate change in Europe there is an obstruction of proper nutrition of forest trees with phosphorus (P). On the other hand, the adequate nutrition of forest trees with P is the factor that could alleviate the negative consequences of drought stress and impruve their tolerance to drought. This assumption is based on the physiological role of P regulating photosynthesis and glycolysis and controling the CO2 assimilation and biomass production. Common beech and sessile oak create mixed forest communities all over Europe while occupying dry and wet habitats with different P concentraions in the soil. Genetic diversity of common beech and sessile oak in Southeastern Europe (including the Republic of Croatia) as well as their intrinsic adaptive variation in response to drought stress has so far been very rarely investigated. In addition, the existence of possible interactions between different genotypes (provenance of common beech and/or sessile oak) exposed to drought stress at different P concentrations in the soil is still unknown, because it will be attempted to determine by this project. Therefore, the primary objectives of this project are: (1) to determine the influence of increased P concentration in soil on tolerance of common beech and sessile oak to drought stress, (2) to determine if there is a local adaptation of the common beech and sessile oak provenances to drought stress, as well as genotypic differences in drought tolerance under the influence of increased P concentration in the soil, (3) to determine if there are so-called memory effects (after effects) caused by drought stress in common beech and sessile oak, i.e. the influence of increased P concentration in the soil on such effects. One of the most important contributions of this project is to support economic and general benefit forest functions, which will have a positive impact on the whole society. ]]></summary_en></project><project>
<id>13523</id><title_hr><![CDATA[Afektivni kognitivni trening: Neuralni, kognitivni i bihevioralni učinci]]></title_hr><title_en><![CDATA[]]></title_en><user_id>19040</user_id><user_firstLast_name>Andrea Vranić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-5979</code><acronim><![CDATA[ACT]]></acronim><duration>01.10.2021 - 30.09.2025</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Psihologija, </scie_field_hr><scie_field_en>Psychology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>865096</team_members_id><team_members_names><![CDATA[ Doktorand: Luka Juras ]]></team_members_names><keywords_hr><![CDATA[kogitivni trening, izvršne funkcije, radno pamćenje, afektivna obrada, EEG, model latentnih promjena, kognitivno starenje ]]></keywords_hr><keywords_en><![CDATA[cognitive training, executive functions, working memory, affective processing, EEG; latent change model, cognitive aging]]></keywords_en><summary_hr><![CDATA[Starenje populacije stavlja fokus na intervencije osnaživanja kognicije. Prihvaćenost kognitivnih treninga narušavaju nejednoznačni nalazi njihove učinkovitosti, nejasna teorijska podloga te heterogenost parametara treninga i mjera učinkovitosti. Ključno za učinkovitost je pitanje dalekog transfera, tj. porasta u mjerama netreniranih sposobnosti i svakodnevnog funkcioniranja. Polazeći od sukladne neuralne osnove izvršnih aspekata radnog pamćenja (RP) i afektivne obrade informacija osmišljen je trening temeljen na modelu izvršnih aspekata RP (Miyake i sur., 1999), uz korištenje afektivnih podražaja. Glavni cilj projekta je provjera učinkovitosti ovog treninga, čija je svrha osnaživanje kognicije i svakodnevnog funkcioniranja starijih. Predložena istraživanja odgovaraju na pet ključnih teorijskih pitanja kognitivne plastičnosti (Willis i Schaie, 2009): razina, mehanizmi, trajanje, transfer i individualni kontekst. Projekt ima tri faze: 1) preliminarna istraživanja i priprema protokola treninga, 2) razvoj mjere svakodnevnog funkcioniranja, 3) provjera neuralnih (EEG), kognitivnih i bihevioralnih učinaka treninga na uzorku koji osigurava uvjete za analize promjena na latentnoj razini. Očekuje se evidentiranje plastičnosti na neuralnoj, kognitivnoj i bihevioralnoj razini te postuliranje njihova međuodnosa. Analiza multigrupnih latentnih promjena omogućuje zaključivanje o promjenama u strukturi kognitivnih funkcija nakon treninga i njihovom transferu na svakodnevno funkcioniranje, što u tradicionalnim istraživanjima treninga zbog malog uzorka i heterogenih mjera učinaka nije osigurano. Istraživanje ima teorijski i praktičan značaj. Ono osigurava spoznaje o međuodnosu razina i mehanizma plastičnosti te njihovog dosega, ključne za napredak područja, a ujedno omogućava sofisticiranu provjeru modela izvršnih funkcija RP. U vrijeme kada osnaživanje kognitivnih funkcija postaje društveni imperativ, projekt će osigurati ekonomičnu i lako dostupnu intervenciju.]]></summary_hr><summary_en><![CDATA[Aging of the population puts a strong emphasis on cognitive training interventions. Studies on training efficacy show ambiguous results due to the heterogeneity in design, method, training protocols, outcome measures and a relative lack of models explaining the gains. A key to training efficacy is far-transfer, i.e. the post-training gain in untrained abilities and everyday functioning. Based on the neural overlap in affective processing and executive working memory (WM), we propose an affective cognitive training grounded in the model of executive function of WM (Miyake et al., 1999). The main goal of the project is the analysis of training, aimed at enhancing cognition and the daily functioning in elderly. Overall, the proposed research conforms to the five key theoretical questions of cognitive plasticity (Willis and Schaie, 2009): level, mechanisms, duration, transfer and individual context. The project has three phases: 1) preliminary preparation of training protocol, 2)  development and validation of measure of everyday functioning, 3) neural (EEG), cognitive and behavioral effects of cognitive training - latent gain analysis. We expect evidence of plasticity at neural, cognitive and behavioral level and the postulation of the interrelation of these effects. The multigroup latent change analysis will enable inferences on the training-related change in the structure of cognitive abilities and their transfer, which is not enabled in typical small sampled studies with heterogeneous outcomes. The project has important theoretical and practical significance. While providing a sophisticated analysis of the model of executive functions of WM, it will provide new insights into the interdependence of different levels and mechanisms of plasticity and their impact on the aspects of everyday functioning in middle-aged adults. At the time when cognitive enhancement becomes a social imperative, the project might ensure a cost-effective and easily accessible intervention.]]></summary_en></project><project>
<id>13526</id><title_hr><![CDATA[Karakterizacija i monitoring rasjednog sustava šireg dubrovačkog područja]]></title_hr><title_en><![CDATA[]]></title_en><user_id>199</user_id><user_firstLast_name>Josip Stipčević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-2609</code><acronim><![CDATA[DuFAULT]]></acronim><duration>14.10.2021 - 13.10.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Geofizika, </scie_field_hr><scie_field_en>Geophysics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>858437</team_members_id><team_members_names><![CDATA[ Doktorand: Helena Latečki ]]></team_members_names><keywords_hr><![CDATA[Dubrovnik, potres, rasjed, modeliranje, građa Zemljine kore]]></keywords_hr><keywords_en><![CDATA[Dubrovnik, earthquake, fault, modelling, crustal structure]]></keywords_en><summary_hr><![CDATA[Hrvatska, a posebice njen južni dio nalazi se na potresno aktivnom prostoru kojeg, u usporedbi s velikim dijelom Europe, karakterizira visoka stopa seizmičnosti. Prema hrvatskom katalogu potresa na ovom području se dogodilo mnogo jakih potresa od kojih je posebice razoran bio veliki dubrovački potres iz 17. stoljeća. Dobro poznavanje građe kore i precizna lokacija žarišta potresa imaju ključnu ulogu u određivanju aktivnih rasjeda, a time i procjeni seizmičkog hazarda. Ove komponente do sada nisu bile određene na zadovoljavajući način za jugoistočni dio Jadrana ponajprije zbog nepovoljnog rasporeda i malog broja seizmoloških postaja na tom području. U ovom projektnom prijedlogu, naš glavni cilj je procjeniti seizmogeni potencijal te okarakterizirati promjenu stanja rasjednog sustava šireg dubrovačkog područja na temelju novo prikupljenih podatka uz upotrebu modernih geofizičkih metoda. Da bismo ispunili navedene ciljeve prikupit ćemo skup visoko kvalitetnih seizmološki podataka kroz uspostavu privremene mreže seizmoloških postaja povezujući novo instalirane postaje s već postojećima iz nekoliko nacionalnih seizmografskih mreža u okolici. Uz upotrebu novo prikupljenih podataka te primjenu i unaprijeđenje modernih seizmoloških metoda planiramo odrediti 3D strukturu kore, mapirati rasjedni sustav, poboljšati praćenje seizmičnosti te odrediti ulogu dubrovačkog rasjednog sustava unutar šire slike tektonskih procesa u Mediteranu. Novi uvid u seizmičnost, građu litosfere i tektonske procese u široj dubrovačkoj regiji omogućit će da simuliramo realni scenarij velikog potresa te rasprostiranje potresnih valova na tom području što će u konačnici pridonijeti boljoj procjeni seizmičkog hazarda. Takvi seizmološki rezultati u kombinaciji s LIDAR mapiranjem, batimetrijom, geološkim i geodetskim istraživanjima, koja se već provode ili su planirana u skoroj budućnosti, omogućit će jedinstveni uvid u geodinamiku i karakter rasjednog sustava u ovoj regiji sklonoj potresima.]]></summary_hr><summary_en><![CDATA[Croatia and especially its southern part is located in a seismically very active region characterized by relatively high earthquake rates when compared to the rest of Europe. The historical seismicity catalogue for this region includes numerous strong events, with the 17th century Dubrovnik earthquake being particularly significant. Detailed knowledge about the upper crustal structure and seismicity pattern is crucial for e.g. hazard modelling and for south-eastern Adriatic, these are still missing, mostly due to unfavourable spatial layout and insufficient density of seismic stations in the area. In this project proposal, our main aim is to assess the seismogenic potential of the Dubrovnik fault system and the fault behaviour by collecting new high-resolution seismic data, applying and improving the most recent geophysical methods. In order to fulfil our objectives, we will collect new and high-quality seismic data by establishing a semi-permanent observatory to complement the existing network. By using the new data and by applying and improving existing methods, we aim to assess in much greater detail than previously possible the 3D crustal structure, the seismicity, fault system anatomy, tectonic stress accumulation rate, and the physics of the lithospheric forces within the dynamic broad picture of the Mediterranean tectonic processes. These new insights will allow for the development of a detailed 3D model of the crust that would in return enable 3D simulations of wave propagation and local seismic hazard assessment. Such seismological results, combined with e.g. geological data, LIDAR mapping, bathymetry, or geodetic (GPS and InSAR) investigations – all of which are either on-going in Croatia, or are planned for the near future – will be fundamental for studies of geodynamics as well as for characterization of active faults in this earthquake-prone area.]]></summary_en></project><project>
<id>13527</id><title_hr><![CDATA[EIKOSANOIDI IZVEDENI IZ DIJETE I FENOTIPI U SEPSI]]></title_hr><title_en><![CDATA[]]></title_en><user_id>29401</user_id><user_firstLast_name>Christian Reynolds</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-7992</code><acronim><![CDATA[]]></acronim><duration>01.10.2021 - 31.03.2026</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Interdisciplinarno područje znanosti</scie_area_hr><scie_area_en>Interdisciplinary scientific area</scie_area_en><scie_field_hr>Biotehnologija u biomedicini, </scie_field_hr><scie_field_en>Biotechnology in Biomedicine, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci]]></institution_hr><institution_en><![CDATA[University of Rijeka]]></institution_en><team_members_id>865069</team_members_id><team_members_names><![CDATA[ Doktorand: Nada Birkić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>13529</id><title_hr><![CDATA[Nutritivna i funkcionalna vrijednost koprive (Urtica dioica L.) primjenom suvremenih hidroponskih tehnika uzgoja]]></title_hr><title_en><![CDATA[]]></title_en><user_id>19134</user_id><user_firstLast_name>Jana Šic Žlabur</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-7914</code><acronim><![CDATA[URTICA-BioFuture]]></acronim><duration>13.01.2022 - 12.01.2026</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Agronomski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Agriculture]]></institution_en><team_members_id>865271</team_members_id><team_members_names><![CDATA[ Doktorand: Mia Dujmović ]]></team_members_names><keywords_hr><![CDATA[kopriva, hidroponski uzgoj, vodni stres, specijalizirani metaboliti, antioksidacijska aktivnost ]]></keywords_hr><keywords_en><![CDATA[nettle, hydroponic cultivation, drought stress, specialized metabolites, antioxidant activity]]></keywords_en><summary_hr><![CDATA[Kopriva je višegodišnja biljka bogata fitokemikalijama i specijaliziranim metabolitima (SM), što ju svrstava u kategoriju biljaka velikog potencijala i široke primjene. Iako raste samoniklo u prirodi, teži se njenoj kultivaciji u svrhu dobivanja gotovog proizvoda ujednačenog kemijskog sastava. Odabranim agrotehničkim mjerama tijekom fenofaza u razvoju biljke značajno se može utjecati na sintezu i akumulaciju SM, koji su pod izravnim utjecajem brojnih biotskih, abiotskih i antropogenih čimbenika. Ključni čimbenici za dobivanje nutritivno kvalitetnog proizvoda adekvatnog prinosa uključuju balansiranu gnojidbu, fenofazu razvoja i dinamiku košnje. Sve evidentnije klimatske promjene potenciraju implementaciju suvremenih metoda uzgoja. Suvremene tehnike proizvodnje povrća podrazumijevaju hidroponski uzgoj koji pokazuje niz prednosti: dobro gospodarenje prirodnim resursima, racionaliziranu potrošnju vode zbog recirkulacije hranive otopine, sprječavanje gubitka hraniva iz rizosfere, kontrolu abiotskih čimbenika hranive otopine te zraka. Prilikom plasmana proizvoda na tržište, a u svrhu što duljeg očuvanja nutritivnih i organoleptičkih kvaliteta te trajnosti proizvoda, nužno je pakiranje istog s ciljem smanjenja kontakta svježe koprive s atmosferom okoliša. Ključni čimbenici prilikom pakiranja su odabir adekvatnog ambalažnog materijala i sastav plinova u pakiranjima. Pakiranje u modificiranoj atmosferi značajno usporava degradaciju nutritivnih svojstva svježe ubrane biljke uz osiguravanje mikrobiološke ispravnosti pakiranog proizvoda.]]></summary_hr><summary_en><![CDATA[Nettle is a perennial plant rich in phytochemicals and specialized metabolites (SM), often categorized as a product of great potential and wide usage. Although wild nettle is widespread in nature, its cultivation is necessary in order to achieve known chemical composition of final product. Agro-technical measures during different phases in plant&#39;s development can considerably impact the synthesis and accumulation of SM, which are directly influenced by numerous biotic, abiotic and anthropogenic factors. Key factors for obtaining a nutritive high quality product of adequate yield include balanced fertilization, plant development stage and harvest period. More evident climatic changes encourage the implementation of modern growing methods. Modern vegetables growing methods include hydroponic cultivation which shows number of advantages: good natural resources management, rationalized water consumption because of nutrient solution recirculation, preventing loss of nutrients from the rhizosphere, control of abiotic factors of nutrient solution and air. During the product market placement with an aim of longer nutritive and organoleptic qualities preservation and durability of the product it is necessary to pack the product with a goal to reduce the contact of fresh nettle with the surrounding atmosphere. Key factors during packaging are selection of adequate packaging material and gases composition in package. Packaging in a modified atmosphere significantly reduces the degradation of nutritional properties of fresh plant material while ensuring the microbiological safe of the packaged product.]]></summary_en></project><project>
<id>13530</id><title_hr><![CDATA[Kvaliteta života u stambenim naseljima iz socijalističkog i postsocijalističkog razdoblja: komparativna analiza između Slovenije i Hrvatske]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6259</user_id><user_firstLast_name>Anđelina  Svirčić Gotovac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-4740</code><acronim><![CDATA[HESC]]></acronim><duration>01.10.2021 - 30.09.2025</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Sociologija, </scie_field_hr><scie_field_en>Sociology, </scie_field_en><institution_hr><![CDATA[Institut za društvena istraživanja]]></institution_hr><institution_en><![CDATA[Institute for Social Research in Zagreb]]></institution_en><team_members_id>865093</team_members_id><team_members_names><![CDATA[ Doktorand: Anamaria Klasić ]]></team_members_names><keywords_hr><![CDATA[kvaliteta života, stambena naselja, socijalističko razdoblje, postssocijalstičko razdoblje, komparativna analiza, Hrvatska, Slovenija]]></keywords_hr><keywords_en><![CDATA[quality of living, housing estates, socialism, post-socialism, comparative analysis, Croatia, Slovenia]]></keywords_en><summary_hr><![CDATA[U planiranom projektu fokus je na kvaliteti života u stambenim naseljima koja su izgrađena u razdoblju socijalističkog društveno-političkog i ekonomskog sustava te u razdoblju nakon prijelaza na tržišnu ekonomiju (postsocijalizam). Polazi se od hipoteze da su različite društvene okolnosti koje karakteriziraju postsocijalističko razdoblje donijele nove zahtjeve i potrebe u kvaliteti života stanovnika jer su naselja iz socijalističkog razdoblja postala manje atraktivna za život, jer stanovnici imaju nove vrijednosti i potrebe u pogledu kvalitete života i veća očekivanja za boljim stambenim standardom i kvalitetom stambenog okruženja. Istraživanje je osmišljeno kao komparativno, jer se testira hipoteza za dvije države - Sloveniju i Hrvatsku, koje imaju isti temelj za nastanak velikih stambenih naselja izgrađenih tijekom socijalističkog razdoblja. Bez obzira na promjene i razlike, velika stambena naselja iz socijalizma u obje zemlje i dalje predstavljaju značajan udio ukupnog stambenog fonda, za koji se pretpostavlja da nije adekvatan te da zbog zastarjelosti i promijenjenih vrijednosti treba cjelovitu obnovu. Međutim, nijedna od navedenih zemalja nije usvojila nacionalnu strategiju obnove velikih stambenih naselja ili smjernice za osiguranje više kvalitete stambenog i životnog okruženja. Krajnji je cilj istraživačkog projekta stoga definirati - s gledišta kvalitete života - smjernice i preporuke za odgovarajuću obnovu stambenih naselja iz socijalističkog razdoblja i za planiranje novih stambenih naselja u Sloveniji i u Hrvatskoj. Osnova za oblikovanje prijedloga za pripremu obje nacionalne strategije bit će sličnosti i razlike u percepcijama kvalitete života stanovnika stambenih naselja i njihovih potreba u odnosu na promijenjene vrijednosti povezane s načinom života. Istraživanje će stoga biti izvorno, a razvijene smjernice bit će relevantne i za ostale postsocijalističke zemlje.]]></summary_hr><summary_en><![CDATA[The focus is on the quality of living in the housing estates built in the period of the socialist socio-political and economic system and the period after the transition towards market economy (the post-socialist era). The hypothesis is that the various social circumstances characterizing the post-socialist period have brought new demands and needs in residents&#39; quality of living. The settlements from the socialist period have become less attractive for living, because residents have new values and needs regarding the quality of living, and higher expectations towards a better housing standard and a better quality of the living environment. The research is conceptualised as comparative, because the hypothesis is tested for two countries – Slovenia and Croatia. Both countries have the same foundation for the occurence of large housing settlements built during the socialist period. Large housing settlements from socialism still represent a significant proportion in total housing in both countries, which is presumed to be inadequate and in need of a comprehensive renovation, due to obsolence and changed values. None of the mentioned countries has adopted a national strategy of the renovation of large housing settlements, or the directives for assuring higher quality of the housing and living environment. It is therefore the overall goal of the research project to define, from the viewpoint of the quality of living, the guidelines and recommendations for adequate renovation of the housing settlements from the socialist period and for planning new housing settlements. The basis for outlining the proposal for the preparation of both national strategies will be the similarities and differences in understanding and perceptions of the quality of living among residents of housing settlements, in relation to changed values regarding the way of living. The research will therefore be original and the guidelines developed will be relevant for other post-socialist countries.]]></summary_en></project><project>
<id>13531</id><title_hr><![CDATA[Školjkaši: Arhiva okolišnih promjena u obalnim morskim ekosustavima]]></title_hr><title_en><![CDATA[]]></title_en><user_id>667</user_id><user_firstLast_name>Melita Peharda Uljević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-5210</code><acronim><![CDATA[BivACME]]></acronim><duration>01.10.2021 - 01.10.2025</duration><status>Prekinut</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut za oceanografiju i ribarstvo]]></institution_hr><institution_en><![CDATA[Institute of Oceanography and Fisheries]]></institution_en><team_members_id>865044</team_members_id><team_members_names><![CDATA[ Doktorand: Kristina Križnjak ]]></team_members_names><keywords_hr><![CDATA[sklerokronologija, školjkaši, ekologija mora, okolišne promjene, atmosfer-ocean klimatski modeli, geokemija ljuštura]]></keywords_hr><keywords_en><![CDATA[sclerochronology, bivalve, marine ecology, environmental change, atmosphere-ocean climate model, shell geochemistry]]></keywords_en><summary_hr><![CDATA[Sklerokronologija je supra disciplinarno područje, u kojem se zone prirasta u čvrstim dijelovima morskih organizama i geokemijske varijacije u njima koriste za stvaranje neprekidnog, više desetljeća dugog, vremenskog niza o rastu organiztama i varijabilnosti morskog okoliša. Projekt BivACME primijenit će sklerokronološki pristup u proučavanju nekoliko kraće živućih gospodarsko važnih vrsta školjkaša (Callista chione, Venus verrucosa, Pecten jacobaeus, Aequipecten opercularis) kao i zaštićene mediteranske endemske vrste školjkaša (Pinna nobilis). Uzorkovanja će se geografski protezati preko hrvatskih granica, a obuhvatit će talijanski dio sjevernog Jadrana, kao i južni Jadran koji pripadaju Crnoj Gori, kako bi uključio širi geografski i okolišni gradijent. Istraživačke aktivnosti temeljit će se na analizi zona prirasta, stabilnih izotopa kisika i ugljika u ljušturama i zapisa elemenata u ljušturama. Nadalje, u ovom projektu planiramo uključiti analizu izotopa dušika u ljušturama, kao i tkiva školjkaša, kako bismo analizirali promjene u priobalnom morskom okolišu. Najbolji raspoloživi proizvod, dugoročna simulacija AdriSC-a (1987.-2017.), koristit će se za kvantificiranje veza između parametara dobivenih iz školjkaša i varijabilnosti okoliša. Rezultati projekta BivACME pridonijet će razvoju metoda za procjenu ekoloških čimbenika rasta školjkaša, kao i uvid u procese i trendove koji bi mogli biti korisni za pravilnu kvantifikaciju prošlih promjena u okolišu. Ciljane vrste su gospodarski važne, stoga će predloženo istraživanje doprinijeti znanju potrebnom za omogućavanje održivog iskorištavanja školjkaša i akvakulture u promjenjivim morskim obalnim ekosustavima.]]></summary_hr><summary_en><![CDATA[Sclerochronology is a supra disciplinary field, where growth increments in hard parts of marine organisms and geochemical variations are used to generate uninterrupted multi decadal time-series of growth and marine environmental variability. BivACME project will apply sclerochronology approach to study of several shorter living commercially important bivalve species (Callista chione, Venus verrucosa, Pecten jacobaeus, Aequipecten opercularis) as well as protected Mediterranean endemic bivalve Pinna nobilis. Sampling will extend geographically, over Croatian boundaries, and will include Italian part of the northern Adriatic Sea as well as southern Adriatic waters that belong to Montenegro, in order to encompasses a wider geographical and environmental gradient. Research activities will be based on the analysis of growth increments, oxygen and carbon isotopes and element records in shell. Furthermore, in this project we plan to include analysis of nitrogen isotopes in the shell, as well as in bivalve tissue, to analyse changes in coastal marine environment. The best available product, the AdriSC long-term simulation (1987-2017), will be used in quantifying connections between bivalve-derived parameters and environmental variability. Results of the BivACME project will contribute toward developing methods for assessment of environmental drivers of bivalve growth, as well as provide an insight into processes and trends which might be useful for proper quantification of the past changes in the environment.  Target species are commercially important, thus, the proposed research will contribute to knowledge needed for enabling sustainable bivalve harvesting ad aquaculture in changing marine coastal ecosystems.]]></summary_en></project><project>
<id>13532</id><title_hr><![CDATA[Nagle klimatske promjene – Dokazi iz kvartarnih sedimentoloških zapisa u Hrvatskoj]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3320</user_id><user_firstLast_name>Lidija Galović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-9476</code><acronim><![CDATA[ACCENT]]></acronim><duration>20.08.2021 - 31.07.2027</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Geologija, </scie_field_hr><scie_field_en>Geology, </scie_field_en><institution_hr><![CDATA[Hrvatski geološki institut]]></institution_hr><institution_en><![CDATA[Croatian Geological Survey]]></institution_en><team_members_id>865108</team_members_id><team_members_names><![CDATA[ Doktorand: Nina Hećej ]]></team_members_names><keywords_hr><![CDATA[Nagle klimatske promjene, Kvartar, prapor, Đurđevački pijesci, fluvioglacijalnim sedimenti, Vrgoračko jezero, Hrvatska]]></keywords_hr><keywords_en><![CDATA[Abrupt climate changes, Quaternary, loess, The Đurđevac Sands, fluvioglacial sediments, The Vrgorac Lake, Croatia]]></keywords_en><summary_hr><![CDATA[Istraživanje kvartarnih sedimenata (HRZZ projekt SAPIQ) rezultiralo je značajnim otkrićima u prapor-paleotlo sekvencijama i u Đurđevačkim pijescima u panonskom području (kontinentalna klima) te u fluvioglacijalnim sedimentima u podnožju Velebita i u Vrgoračkom jezeru u dinarskom području (mediteranska klima).U prapor-paleotlo sekvencijama otkriveno je 16 kumuličnih horizonata razvijenih u krovini dobro razvijenih paleotala. Oni predstavljaju paleoklimatske zapise dinamike i razvoja 16 klimatskih promjena. Predloženo istraživanje bit će usredotočeno na analizu kumuličnih horizonata u SI Hrvatskoj, dajući detaljan opis prijelaza iz toplog u glacijalno razdoblje tijekom gornjeg pleistocena. Osim toga, istraživanje paleotala i geomorfološko/sedimentoloških obilježja Đurđevačkih pijesaka može pomoći u utvrđivanju prirode prijelaza pleistocen-holocen na ovom području, kao i potencijalnih paleoekoloških promjena izazvanih holocenskim klimatskim promjena. Ti terestički zapisi na jugu Karpatskog bazena pružit će uvid u intenzitet, trajanje i prostornu varijabilnost klimatskih promjena. Na temelju dobivenih rezultata bit će korelirani sedimentološki zapisi klimatskih promjena tijekom gornjeg pleistocena i holocena u kontinentalnom dijelu Hrvatske (kontinentalna klima) s onima u dinarskom (jadranskom) dijelu Hrvatske (mediteranska klima) (lokacije udaljene samo 300 km), dajući uvid kako su se klimatske promjene manifestirale na udaljenim eolskim-fluvioglacijalnim-jezerskim facijesima JI Europe. Dobiveni podaci čine osnovu za kontinentalnu korelaciju s Europskim pojasom pijeska (SZ Europe) i s Jadranskim morem. Rezultati ovog projekta omogućit će predviđanje dinamike transformacija povezanih s trendovima klimatskih promjena u tim klimatskim regijama i primjene održivog upravljanja zemljištem, posebno u pogledu geo-hazarda poput klizišta, odrona, debritnih tokova, poplava i premještanja dina.]]></summary_hr><summary_en><![CDATA[The exploration of Quaternary sediments (HRZZ project SAPIQ) has resulted in significant findings in loess-palaeosoil sequences and the Đurđevac Sands in the Pannonian area (continental climate) and fluvioglacial sediments in the foothills of the Velebit Mt. and in the Vrgorac Lake in the Dinaric area (mediterranean climate).Explorations of loess-palaeosoil sequences revealed the existence of the 16 cumulic horizons, which evolved just above well-developed palaeosoils. They represent paleoclimate archives of dynamics of the 16 climate changes. The proposed research will be focused on analysing cumulic horizons in NE Croatia, providing detailed descriptions of transitions from the warm to the glacial period in the Upper Pleistocene. In addition, the investigation of palaeosoils and geomorphological/sedimentological features in the dunes of the Đurđevac Sands may help to determine the nature of the Pleistocene-Holocene transition in this area, as well as potential Holocene climate-related palaeoenvironmental changes. These terrestrial archives in the S Carpathian Basin will provide insight into the magnitude, timing and spatial variability of climate changes. Results will represent milestones for correlation of the Upper Pleistocene and Holocene sedimentological archives of climate changes in the continental part of Croatia with those in the Dinaric (Adriatic) part of Croatia (locations only 300 km away). This will yield insight into aeolian-fluvioglacial-lacustrine teleconnections in SE Europe. The obtained data form the basis for supraregional correlations with the European Sand Belt (NW Europe) and the Adriatic Sea. The outcomes of this project will allow predicting the dynamics of the transformations related to trends of climate changes in these climatic regions and application by sustainable land-use managment, especially concerning geohazards like landslides, slumps, debris flows, floods and drifting dunes.]]></summary_en></project><project>
<id>13533</id><title_hr><![CDATA[Visoko razlučiva spektrometrija x-zraka fokusiranim ionskim snopovima]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4589</user_id><user_firstLast_name>Stjepko Fazinić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-1027</code><acronim><![CDATA[Hi-REXS]]></acronim><duration>06.07.2022 - 05.07.2026</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>864847</team_members_id><team_members_names><![CDATA[ Doktorand: Anja Mioković ]]></team_members_names><keywords_hr><![CDATA[analiza ionskim snopovima, ionska mikroproba, visoko-rezolucijski spektri x-zraka, strukturni i kemijski efekti na x-zrake, višestruke ionizacije]]></keywords_hr><keywords_en><![CDATA[ion beam analysis, ion microprobe, high-resolution x-ray spectra, structural and chemical effects on x-rays, multiple ionizations]]></keywords_en><summary_hr><![CDATA[Tehnike ionskih snopova s akceleratorima koriste se za analize materijala ionskim snopovima (IBA) ili kao alat za brzu i efikasnu modifikaciju materijala ili kreiranje radijacijskih oštećenja u čvrsim tijelima. Povjerenje u analitičke tehnike poput IBA, osobito onih koje se baziraju na znanju fundamentalnih parametara interakcija, ovisi o razumijevanju fizikalnih procesa koje se kriju u temeljima tehnike, te u definiranim analitičkim protokolima. Ovdje predlažemo istraživanja fizikalnih procesa od važnosti za metode spektroskopije x-zraka (XES). Istraživati ćemo utjecaj strukturnih i kemijskih efekata na spektare x-zraka visoke rezolucije nakon pobude ionskim snopovima, uključujući istraživanje efekata na K x-zrakama za elemente od Mg do Fe, emisiju satelitskih x-zraka karakterističnih za višestruke ionizacije težim ionima, te efekte na L i M linijama x-zraka težih elemenata. Značajno ćemo unaprijediti IBA mogućnosti na ionskoj mikroprobi IRBa izgradnjom naprednog WDXRS spektrometra te ćemo demonstrirati njegovu upotrebljiivost i važnost određenih fundamentalnih parametara u istraživanjima objekata kulturnog nasljeđa te u istraživanju materijala, uključujući studije in-situ strukturnih i kemijskih promjena materijala uslijed iradijacije ionskim snopovima. Većina eksperimenata bit će obavljena koristeći ionsku mikroprobu Instituta Ruđer Bošković (IRB). Osim toga, koristit ćemo druge linije na akceleratorima IRBa te obaviti četiri terenska eksperimenta na sinhrotronima i drugim akceleratorima koji imaju spektrometre x-zraka visoke rezolucije da bi dobili komplementarne rezultate. Na kraju projekta novorazvijeni spektrometar bio bi na raspolaganju istraživačima za istraživanja raznih fenomena te za interdisciplinarne primjene. Također, naši mlađi istraživači steći će veliko iskustvo i znanje koje će biti vrlo relevantno za razvoj njihovih budućih karijera. Osim znanstvenih radova očekuju se i konkretni rezultati istraživanja objekata kulturnog nasljeđa.]]></summary_hr><summary_en><![CDATA[Accelerator-based ion beam techniques play prominent roles either in ion beam analysis (IBA) or as tools for fast and efficient modification of materials or creation of radiation damage in solids. Confidence in analytical techniques like IBA, in particular those that rely on knowledge of fundamental interaction parameters, is based on understanding of physical processes that lay behind the particular technique and in defined analytical protocols. We propose to study physical processes of importance for x-ray emission spectroscopy (XES) techniques. We will study structural and chemicall effects on high resolution x-ray spectra emitted after excitation by ion beams, including studies of solid state and chemical effects to K x-rays for elements from Mg to Fe, emission of multiple ionization x-ray satellites by heavy ions, and effects to L and M x-rays of heavier elements. We will significantly increase capabilities for IBA at the RBI ion microbeam station by building new advanced high resolution WD x-ray spectrometer (WDXRS) and proof its usefulness and importance of fundamental data in the fields of preservation/analysis of cultural heritage objects and in materials science, including  studies of in-situ structural and chemical changes of material under ion beam irradiation. Most of the experimental work will be performed using ion microprobe available at the RBI Tandem Accelerator Facility. In addition, we will use the other facility beamlines to complement the research outcome and we will perform four field experiments at synchrotrons and high resolution XRS facilities abroad. At the project end, newly developed WDXRS system will be on disposal to researchers to study various phenomena and interdisciplinary applications. Our younger researchers will obtain valuable experience and knowledge that will be very relevant for their future cariers. Besides research papers, some relevant results related to preservation of cultural heritage are expected.]]></summary_en></project><project>
<id>13534</id><title_hr><![CDATA[Podpovršinski preferencijalni transportni procesi u poljoprivrednim padinskim tlima]]></title_hr><title_en><![CDATA[]]></title_en><user_id>26843</user_id><user_firstLast_name>Lana Filipović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-2914</code><acronim><![CDATA[SUPREHILL]]></acronim><duration>01.10.2021 - 30.09.2025</duration><status>Prekinut</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Agronomski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Agriculture]]></institution_en><team_members_id>865057</team_members_id><team_members_names><![CDATA[ Doktorand: Luka Han ]]></team_members_names><keywords_hr><![CDATA[hidropedologija, agrokemikalije, vadozna zona tla, lizimetri, preferencijalni tok, numerički modeli, opservatorij kritične zone]]></keywords_hr><keywords_en><![CDATA[hydropedology, agrochemicals, soil vadose zone, preferential flow, lysimeters, numerical models, critical zone observatory]]></keywords_en><summary_hr><![CDATA[Padinska poljoprivredna tla karakteriziraju značajne lokalne heterogenosti zbog kojih se javljaju procesi preferencijalnog toka vode u tlu te posljedično, neujednačeno vlaženje tla i nelinearni pronos agrokemikalija (gnojiva i pesticida). Primjer navedenih procesa, a koji se osobito negativno odražavaju na kvalitetu tla i vodnih resursa, su površinsko otjecanje, erozija, vertikalni pronos (procjeđivanje), podpovršinski preferencijalni tok te nelinearno ponašanje kemikalija; svi pod dodatnim utjecajem korijena biljke i evapotranspiracije. Stoga se kritična (nesaturirana) zona padinskih tala, smještena između površine tla i podzemne vode, smatra jednim od najsloženijih terestričkih sustava na Zemlji. Glavni cilj projekta SUPREHILL formiranje je istraživačke grupe i opservatorija kritične zone za praćenje procesa pronosa tvari na padinskim terenima kako bi se mogao kvantificirati podpovršinski preferencijalni tok vode i nelinearni pronos agrokemikalija. U istraživanju će se koristiti oprema za praćenje stanja na terenu u kombinaciji s laboratorijskim i numeričkim kvantifikacijskim metodama. Poljski će pokus biti opremljen senzorima za mjerenje vodne bilance, klimatskom stanicom te težinskim lizimetrima s neporušenim tlom u svrhu mjerenja izotopa vode, trasera, nitrata, otopljenog organskog ugljika te insekticida na bazi bakra u sustavu tlo-biljka-atmosfera. Interdisciplinarnim će se pristupom omogućiti kvantifikacija nelinearnih procesa u tlu, posebice toka vode i pronosa agrokemikalija. Detaljno praćenje procesa rezultirati će velikom bazom podataka koja će se koristiti za kalibraciju numeričkih modela te za razvoj novih postupaka modeliranja. Rezultati će se moći upotrijebiti za prilagodbu gospodarenja padinskim poljoprivrednim površinama, omogućavajući učinkovitije korištenje vode, hranjiva i pesticida. Također, cilj projekta jest uključivanje u inicijativu europske mreže lizimetara, što će osigurati buduće proširivanje istraživanja.]]></summary_hr><summary_en><![CDATA[Hillslope agricultural soils are characterized by local scale heterogeneities which can trigger preferential transport processes and result in uneven wetting of soil and a non-linear transport of agrochemicals (e.g., fertilizers, pesticides). Negative impact on soil and water resources may originate from these processes, e.g., from surface runoff, erosion, vertical leaching, subsurface preferential flow, nonlinear chemical behavior; also affected by crop uptake and evapotranspiration. Therefore, hillslope soil critical (vadose) zone, located between the soil surface and groundwater, is considered as one of the most complex terrestrial systems. The main objective of SUPREHILL project is to form a new research group and to set up critical zone observatory of transport processes in hillslope soils, aiming to quantify subsurface preferential flow and a nonlinear agrochemical transport. Research will be focused on local scale subsurface processes in soil and performed using field monitoring equipment combined with laboratory and numerical quantification methods. The experimental site will be equipped with a range of sensors for water balance measurements, climatic station and undisturbed weighable field lysimeters for measuring water isotopes, tracers, nitrates, dissolved organic carbon and copper-based insecticides in a soil-plant-atmosphere system. Interdisciplinary approach will ensure quantification of non-linear processes in hillslope soils, especially regarding the soil water flow and agrochemical dynamics. Precise monitoring will produce a large database, later used for numerical model calibration and development of novel modeling procedures. Results can be used for the adjustment of management practices at sloped agricultural sites, leading to more efficient use of water, nutrients and pesticides. Project objective is also to become a part of the Europe-wide lysimeter network initiative, allowing the expansion of the observatory focus through new research topics.]]></summary_en></project><project>
<id>13535</id><title_hr><![CDATA[Karakterizacija radiofotoluminiscentnih dozimetara u poljima teško nabijenih čestica]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4769</user_id><user_firstLast_name>Marija Majer</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-4433</code><acronim><![CDATA[RPLforHCP]]></acronim><duration>01.07.2022 - 31.10.2026</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>865443</team_members_id><team_members_names><![CDATA[ Doktorand: Luka Pasariček ]]></team_members_names><keywords_hr><![CDATA[dozimetrija zračenja, RPL detektor, polja teško nabijenih čestica, dozimetrijska karakterizacija, LET, radioterapija teško nabijenim česticama]]></keywords_hr><keywords_en><![CDATA[radiation dosimetry, RPL detector, heavy charged particle fields, dosimetric characterisation, LET,  heavy charged particle radiotherapy]]></keywords_en><summary_hr><![CDATA[Brojna bazična te primijenjena istraživanja su pokazala da je radiofotoluminiscentna (RPL) dozimetrija pouzdana dozimetrijska metoda za mjerenja u poljima fotona i elektrona. No, u poljima teško nabijenih čestica (HCP), dozimetijska karakterizacija, pogotovo ovisnost odziva detektora o energiji i linearnom prijenosu energije (LET) još uvijek nije dovoljno istražena. Posebni izazovi su upotreba RPL dozimetara u radioterapiji teško nabijenim česticama  te dozimetriji u svemiru i za oba interes jako raste. Zbog sve veće važnosti čestične radioterapije u liječenju karcinoma, nužno je istražiti dozimetrijske metode pri mjerenjima u poljima teško nabijenih čestica i to ne samo duž putanje primarne čestice nego i u okolnom području zbog spoznaje da ozračivanje zdravog tkiva može povećati vjerojatnost nastanka sekundarnog karcinoma. Za istraživanja doza izvan tumora, kao i za &#39;&#39;audite&#39;&#39; snopova, mali pasivni dozimetri, jednostavni za rukovanje (kao npr. RPL) su vrlo prikladni.Predloženo istraživanje doprinjet će razumijevanju dozimetrijskih karakteristika RPL dozimetara za mjerenja i primjenu u poljima teško nabijenih čestica. Sustavno će se ispitati ovisnost odziva detektora o LET-u upadne čestice: najprije koristeći različite HCP-snopove zaustavnih energija dobivenih u akceleratorskom postrojenju na Institutu, a zatim u radioterapijskom centru koristeći terapijske protonske snopove visokih energija. Također, ispitat će se reproducibilnost, slabljene signala i dozna ovisnost. U svim eksperimentima koristit će se i termoluminiscentni dozimetri. Rezultati će se usporediti s dobivenim rezultatima za RPL detektore kao i s dostupnim rezultatima u literaturi. Za sve eksperimente napravit će se teorijski model i Monte Carlo (MC) simulacija  te će se  svi eksperimentalni rezultati usporediti s rezultatima dobivenim Monte Carlo (MC) izračunima.]]></summary_hr><summary_en><![CDATA[Radiophotoluminescent (RPL) dosimetry is proved in many studies to be a reliable dosimetry method successfully used in a large scale for many applications in photon and electron fields. Still, dosimetric characterisation and especially energy and linear energy transfer (LET) dependence of the response in heavy charged particle (HCP) fields have not yet been fully investigated. The particular challenge and lately increasing interest is the use of RPLs in HCP radiotherapy and space dosimetry. The increasing role of HCP radiotherapy in the cancer treatment causes the need to thoroughly investigate the dosimetry methods for HCP measurements not only along the Bragg curve of the primary particle but also in the distal (out-of-field) region due to knowledge that irradiation of the healty tissue, caused by stray radiation, can increase risk of second cancer. For out-of-field phantom studies or beam audits, passive dosimeters of small size and simple in handling (such are RPLs) are very suitable. Proposed research will improve understanding of the dosimetric characteristics of RPLs for their use for measurements in the HCP fields. Particularly, LET dependence of the RPL glass detector response will be systematically investigated: firstly at the RBI accelerator facility using low energy HCP beams and secondly in real conditions at the proton radiotherapy center by using high energy therapeutic proton beams. Also, dosimetric characterisation (reproducibility, fading and dose dependance) will be investigated. All experimental results will be compared with Monte Carlo simulation results. In addition the measurements will be done also with thermoluminescent (TL) dosimeters and comparison with RPLs and published data will be made. ]]></summary_en></project><project>
<id>13536</id><title_hr><![CDATA[Razvoj inovativnih formulacija kliničke prehrane]]></title_hr><title_en><![CDATA[]]></title_en><user_id>66</user_id><user_firstLast_name>IVANKA JERIC</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-5260</code><acronim><![CDATA[]]></acronim><duration>02.11.2021 - 01.11.2025</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>865101</team_members_id><team_members_names><![CDATA[ Doktorand: Barbara Bogović ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>13538</id><title_hr><![CDATA[Mehanizmi nastajanja kalcijevih fosfata na anorganskim nanomaterijalima. Biomimetski put priprave multifunkcionalnih kompozita za regeneraciju čvrstih tkiva]]></title_hr><title_en><![CDATA[]]></title_en><user_id>224</user_id><user_firstLast_name>Maja Dutour Sikirić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-5447</code><acronim><![CDATA[CaPBiomimNanocomp]]></acronim><duration>20.01.2022 - 20.04.2026</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>865265</team_members_id><team_members_names><![CDATA[ Doktorand: Suzana Inkret ]]></team_members_names><keywords_hr><![CDATA[kalcijevi fosfati, anorganski nanomaterijali, bioaktivne molekule, kompoziti, biomimetski biomaterijali]]></keywords_hr><keywords_en><![CDATA[calcium phosphates, inorganic nanomaterials, bioactive molecules, composites, biomimetic biomaterials]]></keywords_en><summary_hr><![CDATA[Moderni način života i sve dulji životni vijek stanovništva rezultira sve većom učestalošću bolesti čvrstih tkiva (kostiju i zuba). Često je jedini način liječenja takvih oboljenja ugradnja implantata s ciljem regeneracije oboljelog ili oštećenog tkiva. Kako bi se izbjegli problemi vezani uz kvalitetu implantata, intenziviran je razvoj i istraživanje novih, inovativnih implant materijala. Pri tome se posebna pažnja pridaje kompozitnim multifunkcionalnim materijalima, koji osim poboljšanih osteoinduktivnih i mehaničkih svojstava, mogu djelovati i kao lokalni terapijski sustavi za isporuku lijekova. Kako bi takvi materijali bili što funkcinoalniji te kako bi se što više racionalizirao njihov dizajn potrebno je poznavati međudjelovanja komponenti kompozita. To vrlo često nije slučaj pa je pristup dizajnu i sintezi takvih materijala uglavnom empirijski.U posljednje vrijeme kompoziti kalcijevih fosfata (CaP) i anorganskih nanomaterijala (NM) privlače pažnju kao novi, široko primjenjivi materijali za regeneraciju čvrstih tkiva. Cilj predloženog projekta je sustavno istražiti međudjelovanja CaP i dvije vrste nanomaterijala NM, i) NM titanijevog dioksida različite morfologije (nanočestice, nanocjevčice, nanožice, nanopločice) i ii) srebrnih nanočestica različitih površinskih modifikacija, kako bi se utvrdio odnos između površinskih svojstava NM (površinske modifikacije, morfologije, gustoće površinskog naboja, kristalne strukture) i svojstava nastalih CaP u uvjetima bliskim fiziološkim. Također, istražit će se utjecaj albumina i hitosana na nastajanje CaP/NM kompozita, te odrediti potencijal njihove primjene kao materijala za regeneraciju čvrstih tkiva testovima imunokompatibilnosti i hemokompatibilnosti.Predloženi projekt doprinijeti će boljem razumijevanju procesa taloženja na nanopovršinama, što će omogućiti racionalniji pristup ne samo u biomimetskoj sintezi novih biokompozita za regeneraciju čvrstih tkiva, već i u sintezi kompozitnih materijala široke primjene.]]></summary_hr><summary_en><![CDATA[Population ageing and modern lifestyle leads to the increased frequency and consequently growing importance of hard tissues (bone and teeth) diseases. Often the only treatment of such diseases is implantation with the aim to regenerate affected tissue. To prevent failures of the hard tissue implants, new and innovative multifunctional implant materials are sought which, in addition to improved osteoinductive and mechanical properties, will act as local drug delivery system. In this sense, composite materials seems to be materials of choice. In order for these materials to be fully functional and to rationalize their design, the interactions between components should be fully understood. This very often is not the case and success stories are commonly result of empirical not systematic approach. New hard tissue regeneration biomaterials emerging in recent years are composite materials based on calcium phosphates (CaPs) and different inorganic nanomaterials (NMs). The aim of the proposed project is to systematically investigate the CaPs interactions with two types of inorganic NMs; i) titanium dioxide NMs of different morphology (nanoparticles, nanotubes, nanowires, nanoplates) and ii) silver nanoparticles of different surface modifications, in order to determine relationship between NMs interface properties (surface modification, morphology, surface charge density, crystal structure) and the properties of forming CaPs solid phase at conditions close to physiological. In addition, the influence of albumin and chitosan on the formation of CaP/NMs composites will be investigated and potential for their application will be determined using immunocompatibility and hemocompatibility tests. The proposed research will enable a deeper insight into precipitation processes on nanosurfaces, which will provide a rational approach not only in biomimetic synthesis of novel biocomposites for hard tissue regeneration but also in synthesis of materials for different applications.]]></summary_en></project><project>
<id>13539</id><title_hr><![CDATA[Detaljan uvid u mehanizme polaronske i ionske vodljivosti u oksidnoj staklo-(keramici)]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3421</user_id><user_firstLast_name>Luka Pavić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-9665</code><acronim><![CDATA[POLAR-ION-GLASS]]></acronim><duration>19.10.2021 - 18.02.2026</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>865074</team_members_id><team_members_names><![CDATA[ Doktorand: Sara Marijan ]]></team_members_names><keywords_hr><![CDATA[staklo, staklo-keramika, ionska vodljivost, polaronska vodljivost, struktura]]></keywords_hr><keywords_en><![CDATA[glasses, glass-ceramics, ionic conductivity, polaronic conductivity, structure]]></keywords_en><summary_hr><![CDATA[Električki vodljiva oksidna stakla važni su elektrolitni/elektrodni materijali koji se sve više primijenjuju u modernim elektrokemijskim uređajima. U ovim staklima tip električne vodljivosti (polaronski, ionski ili miješani ionsko-polaronski) ovisi o sastavu stakla, dok utjecaj međudjelovanja nositelja naboja s lokalnim strukturnim okruženjem definira mehanizam transporta. Zbog strukturne neuređenosti i velike raznolikosti strukturnih jedinica razumijevanje električnog transporta na mikroskopskoj skali u staklu predstavlja veliki izazov. Glavni je cilj predloženog projekta razjasniti mehanizme polaronske i ionske vodljivosti u volframsko- i molibdensko-fosfatnim staklima i staklo-keramici s posebnim naglaskom na povezanost sa strukturom. Predloženo istraživanje sastoji se od tri međusobno povezana koraka: 1) određivanje faktora koji određuju polaronsku vodljivost u binarnim volframsko- i molibdensko-fosfatnim staklima, 2) istraživanje miješanog ionsko-polaronskog transporta u volframsko- i molibdensko-fosfatnim staklima koja sadrže alkalijske okside i 3) ispitivanje utjecaja kristalizacije na električni transport u odabranim modelnim staklima iz koraka 1) i 2) s ciljem priprave vodljive staklo-keramike s prilagodljivim doprinosom ionske i polaronske vodljivosti. Odabrani sustavi posebno su atraktivni za primjenu kao katode u krutim baterijama jer fosforov oksid tvori stakla s alkalijskim i prijelaznim metalnim oksidima u širokom koncentracijskom području što omogućava visoku polaronsku i ionsku vodljivost. Detaljna strukturna i električna karakterizacija neophodna za rasvjetljavanje i povezivanje procesa polaronskog i ionskog transporta u ovim materijalima provest će se nizom naprednih komplementarnih metoda (Ramanska, MAS NMR i EPR spektroskopija, neutronska i rendgenska difrakcija, impedancijska spektroskopija, DC mjerenja), a značajan uvid u elementarne procese gibanja polarona i iona dat će numeričko modeliranje električne provodnosti MIGRATION konceptom.]]></summary_hr><summary_en><![CDATA[Electrically conducting oxide glasses are an important class of electrolyte/electrode materials whose application in modern electrochemical devices are growing rapidly. The type of conduction (polaronic, ionic or mixed polaronic-ionic) in these glasses depends on the composition, while the transport mechanism itself is strongly influenced by the interaction of charge carriers with the local structural environment and understanding it from a microscopic point of view poses a major challenge. The overall aim of the proposed project is to clarify the mechanisms of polaronic and ionic conduction in tungsten phosphate and molybdenum phosphate glasses and glass-ceramics with a special emphasis on their correlation to the structure. The proposed research contains three interconnected steps: 1) identification of factors that govern polaronic conduction in binary tungsten/molybdenum phosphate glasses, 2) investigation of the mixed conduction in tungsten/molybdenum phosphate glasses containing alkali oxides and 3) study of the influence of crystallization on electrical transport in selected glasses from steps 1) and 2) in order to obtain highly conductive glass-ceramics with tuneable contributions of polaronic and ionic conduction. The chosen phosphate glasses are especially attractive for application as cathodes in solid-state batteries because they can accommodate a considerable amounts of transition metal and alkali oxides, and hence exhibit high polaronic and ionic conductivity. Detailed structural and electrical characterizations which are needed for resolving and relating processes of polaronic and ionic transport in these materials will be achieved using various advanced methods (Raman, MAS NMR and EPR spectroscopy, neutron and X-ray diffraction, impedance spectroscopy, DC measurements), while the numerical modelling of electrical conductivity using MIGRATION concept will give additional valuable insights into the elementary processes of polaronic and ionic motions.]]></summary_en></project><project>
<id>13541</id><title_hr><![CDATA[Indirektni utjecaj globalnog zagrijavanja na fiziološke parametre sisavaca prehranom biljkama uzgojenim pri visokoj temperaturi]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6570</user_id><user_firstLast_name>Ivana Šola</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-7292</code><acronim><![CDATA[TEMPHYS]]></acronim><duration>20.12.2021 - 19.12.2025</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>865215</team_members_id><team_members_names><![CDATA[ Doktorand: Daria Gmižić ]]></team_members_names><keywords_hr><![CDATA[globalno zatopljenje, ekosustav, metabolomika biljaka, fiziologija sisavaca, interakcija vrsta, dizajn modela]]></keywords_hr><keywords_en><![CDATA[global warming, ecosystem, plant metabolomics, animal physiology, species interaction, model design]]></keywords_en><summary_hr><![CDATA[Biljke izložene visokoj temperaturi (VT) adaptiraju se na molekularnoj razini kako bi održale normalne fiziološke funkcije. Varijacije u profilu metaboloma, transkriptoma i proteoma mogle bi imati značajan utjecaj na njihovu nutritivnu vrijednost, a indirektno prehranom i na zdravlje životinja. Malo je informacija o učincima biljaka uzgojenih pri VT na fiziologiju životinja koje ih konzumiraju, stoga je važno otkriti utječu li, kako i u kojoj mjeri promjene u biljnim metabolitnim profilima na fiziološke parametre sisavaca koji se njima hrane. Proučavanje fizioloških reakcija životinja na biljke izložene uvjetima VT kao hranu pomoći će razumijevanju prilagodbi ekosustava i projiciranju budućih ekoloških trendova. Naš je cilj istražiti indirektni (hranom posredovan) utjecaj VT okoliša na fiziologiju sisavaca, a kao modelni sustav koristit ćemo brokulu (Brassica oleracea botrytis var. cymosa) i miša (Mus musculus ) soj SWISS. Razvit ćemo HPLC i UPLC-MS/MS metode za analizu biljnih metabolita (flavonoida, hidroksicimetnih i hidroksibenzojevih kiselina, glukozinolata, vitamina B, C, D i E), uspostaviti protokol za in vitro i in vivo analizu indirektnog učinka VT na modelu miša, te u programskom jeziku R statističkim metodama izdvojiti parametre miša koji su najosjetljiviji na hranom posredovanu izloženost VT. Specifični doprinos će uključivati podatke o: a) termosenzitivnim i termostabilnim metabolitima u brokuli, b) metaboličkom i antioksidacijskom odgovoru klica i zrelih biljaka na VT, c) učinku VT na biološku sigurnost (cito- i genotoksičnost, utjecaj na staničnu proliferaciju i stupanj stvaranja ROS-ova) biljnog ekstrakta u stanicama sisavaca, te d) indirektnom (hranom posredovanom) učinku VT na (anti)oksidacijske, imunohematološke, metaboličke i lipidne parametre u serumu, jetri i bubrezima miševa. Rezultati će pridonijeti razumijevanju prehranom posredovanih posljedica globalnog zagrijavanja na životinje.   ]]></summary_hr><summary_en><![CDATA[Plants exposed to high temperature (HT) adapt at molecular level to maintain normal physiological functions. Variations in the metabolome, transcriptome and proteome profiles could have a significant impact on their nutritional value, and indirectly via diet on animal health as well. There are very little data on the effects of HT-grown plants on the physiology of mammals that feed on them, so it is important to find out whether, how and to what extent HT-induced changes in plant metabolites affect the physiology of mammals consuming them. Studying the physiological responses of animals to HT-grown plants as food will help us understand ecosystem adaptation process and project future ecological trends. Our goal is to investigate the indirect (diet-mediated) influence of HT on mammalian physiology, and we will use broccoli (Brassica oleracea botrytis var. cymosa) and mouse (Mus musculus) strain SWISS as a model system. We will develop HPLC and UPLC-MS/MS methods for analysis of plant metabolites (flavonoids, hydroxycinnamic and hydroxybenzoic acids, glucosinolates, vitamins B, C, D and E), establish a protocol for in vitro and in vivo analysis of the indirect effect of HT on mice, and in the programming language R by statistical methods identify mouse physiological parameters that are most sensitive to diet-mediated HT exposure. Specific contributions will include data on: a) thermosensitive and thermostable metabolites in broccoli, b) metabolic and antioxidant response of seedlings and mature plants to HT, c) effect of HT on biosafety (cyto- and genotoxicity, effect on cell proliferation and ROS production) of plant extract in mammalian cells, and d) indirect (diet-mediated) effect of HT on (anti)oxidative, immunohematological, metabolic and lipid parameters in serum, liver and kidneys of mice. The results will contribute to the predictions on diet-mediated indirect effects of global warming on animals.]]></summary_en></project><project>
<id>13542</id><title_hr><![CDATA[Farmakokinetika intravenski i intramuskularno primijenjenog antivenoma u velikom animalnom modelu ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1144</user_id><user_firstLast_name>Tihana Kurtović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-1416</code><acronim><![CDATA[]]></acronim><duration>04.10.2021 - 01.01.2026</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu]]></institution_hr><institution_en><![CDATA[University of Zagreb]]></institution_en><team_members_id>865053</team_members_id><team_members_names><![CDATA[ Doktorand: Erika Gamulin ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>13543</id><title_hr><![CDATA[Sistematika mehanizama u bezotopinskoj ili  tekućinski kataliziranoj sintezi u čvrstom stanju]]></title_hr><title_en><![CDATA[]]></title_en><user_id>625</user_id><user_firstLast_name>Ivan Halasz</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-2795</code><acronim><![CDATA[SystForSynt]]></acronim><duration>22.10.2021 - 21.10.2025</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>865094</team_members_id><team_members_names><![CDATA[ Doktorand: Leonarda Vugrin ]]></team_members_names><keywords_hr><![CDATA[mechanochemistry, reaction mechnism, in situ monitoring, Hammett correlation, catalysis]]></keywords_hr><keywords_en><![CDATA[mehanokemija,  reakcijski mehanizam, in situ monitoring, Hammettova korelacija, kataliza]]></keywords_en><summary_hr><![CDATA[Istraživanje kemijskih transformacija mehaničkim mljevenjem rastuće je područje kemije i znanosti o materijalima, a opseg takvih reakcija ubrzano se širi. Provođenje mehanokemijskih reakcija u zatvorenim reakcijskim posudama, međutim, ograničava istraživanje njihova tijeka, pa su stoga njihovi mehanizmi uglavnom nepoznati. Projektni prijedlog SystForSynt usmjeren je na rješavanje ovog problema prvenstveno u području organskih reakcija. Predlažemo istraživanje u četiri radna paketa, koje smatramo vrlo značajnima, a uključuju provjeru Hammettove korelacije, razumijevanje tekućinske katalize u tekućinski-potpomognutim mehanokemijskim reakcijama, prenosivost mljevenja na ekstruziju i dinamiku atomskog i molekularnog izmjenjivanja mljevenih čestica i konačno, organske reakcije pregradnje te radikalske reakcije. Da bi se to postiglo, projekt SystForSynt primijenit će tehnike praćenja tijeka reaccije in situ, a koje se temelje na Ramanovoj spektroskopiji i rendgenskoj difrakciji na prahu, koje osiguravaju izravan uvid u tijek reakcije bez prekidanja procesa mljevenja, a koje je uveo PI sa suradnicima. Osim toga, za praćenje dinamike mljevenih krutina i specifičnih migracija atoma koristit ćemo izotopno obilježene krute tvari. Očekujemo da će rezultati projekta SystForSynt značajno unaprijediti razumijevanje mehanokemije i s vremenom omogućiti mehanokemiji da se pozicionira kao održivi pristup u sintezi s niskim otpadom te s učinkovitom uporabom resursa i energije. ]]></summary_hr><summary_en><![CDATA[Investigations into chemical transformations by mechanochemical milling is currently a fast growing field of chemistry and material science and the scope of such reactions is rapidly expanding. Conducting mechanochemical reactions in closed reaction vessels is however, limiting investigation into their course and consequently, their mechanisms are largely unknown. The SystForSynt project proposal is to address this very issue in the realm or organic transformations. We propose to conduct research in four work packages, that we recognise as highly significant, and which include verification of the Hammett correlation, understanding of liquid catalysis in liquid-assisted mechanochemical reactions, the transferability of mechanisms from milling to extrusion processing and the dynamics of atomic and molecular exchange between processed  particles and finally, organic rearrangement and radical reactions. To achieve this, the SystForSynt project will employ is situ monitoring techniques based on Raman spectroscopy and powder X-ray diffraction, which provide a direct insight into the reaction course without interrupting the milling process, and which we have pioneered. In addition, we will use isotope labelled solids to monitor the dynamics of milled solids and any specific atomic migrations. Results of the SystForSynt project are expected to significantly advance understanding of mechanochemistry, which will eventually allow mechanochemistry to position itself as a viable processing approach in a low-waste, atom- and energy-efficient synthesis in the future. ]]></summary_en></project><project>
<id>13544</id><title_hr><![CDATA[Topografija srednjovjekovne Zagrebačke županije (14.-16. stoljeće)]]></title_hr><title_en><![CDATA[]]></title_en><user_id>28952</user_id><user_firstLast_name>Hrvoje Kekez</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-3235</code><acronim><![CDATA[MEDITOP]]></acronim><duration>02.11.2021 - 03.12.2026</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Povijest, </scie_field_hr><scie_field_en>History, </scie_field_en><institution_hr><![CDATA[Hrvatsko katoličko sveučilište, Zagreb]]></institution_hr><institution_en><![CDATA[Catholic University of Croatia]]></institution_en><team_members_id>865043</team_members_id><team_members_names><![CDATA[ Doktorand: Matea Jurić ]]></team_members_names><keywords_hr><![CDATA[srednji vijek, topografija, toponimija, Zagrebačka županija, kulturni krajobraz]]></keywords_hr><keywords_en><![CDATA[Middle Ages, topography, toponymy, Zagreb County, cultural environment]]></keywords_en><summary_hr><![CDATA[Rabeći suvremene metode i oslanjajući se na recentne istraživačke paradigme, prijedlog istraživanja u svoj najuži fokus postavlja istraživanje topografije srednjovjekovne Zagrebačke županije (od 14. do 16. stoljeća) temeljen na sustavnome radu s vrelima, s naglaskom na specifičnim vrstama vrela i arhivskim fondovima koji su osobito bogati topografsko-toponimijskom građom. Takav pristup obuhvatit će više istraživačkih razina: od temeljne koja podrazumijeva rekonstrukciju temeljnih značajki analiziranoga prostora, do složenijih koje se tiču istraživanja odnosa povijesnih društava i njihovoga okoliša. U prvoj fazi rada istraživački će tim prikupiti i obraditi srednjovjekovne toponimijske potvrde, ne samo iz objavljenih zbirki izvora, već i iz neobjavljenih arhivskih fondova. Podatci iz pisanih i kartografskih vrela biti će digitalizirani i upotpunjeni terenskim istraživanjima. Ograničavajući se na područje povijesne Zagrebačke županije istraživački će se tim moći usmjeriti – uz središta srednjovjekovnih župa, trgovišta i druge centre naseljenosti – na mikroregionalne cjeline, mikrotoponime te granične linije (odnosno pojaseve razgraničenja na različitim razinama, administrativnim, simboličkim, povijesnim itd.). Osim brojnih istraživačkih pitanja povezanih s povijesnim okolišem (utjecaj okoliša na povijesna zbivanja, utjecaj društvenih zajednica na promjenu prostora), među najvažnijim je ciljevima istraživanja artikulacija temeljnih obilježja odnosa čovjeka i prostora u dijakronijskoj perspektivi. Navedeni će ciljevi biti postignuti povezivanjem spoznaja o topografiji i toponimiji dobivenih analizom povijesnih potvrda i rekonstrukcijom vanjskih obilježja analiziranoga prostora. ]]></summary_hr><summary_en><![CDATA[This proposed research project intends to focus on researching the topography of the medieval County of Zagreb (from the 14th to the 16th century), by using modern research methods and relying on recent research paradigms. Its basis would be a consistent study of primary sources, with an emphasis on specific types of sources and archive funds particularly rich in topographically and toponymycally relevant material. Such an approach would demand several levels of research, from the basic level, meaning a reconstruction of fundamental characteristics of the analyzed area, to complex levels dealing with the relations between past societies and their environment. During the first phase of the project, the research team would gather and analyze medieval toponymical data, not only from printed collections of sources, but also from unpublished archive material. By limiting itself to the area of the medieval Zagreb County, the research team would be able to focus not only on medieval parish seats, market towns and other population hubs, but also on micro-regional units, micro-toponymics and border lines (or rather, border belts on various levels – administrative, symbolic, historical etc.). Besides tackling a number of issues regarding environmental history (influence of the environment on historical events, influence of communities on environmental changes), one of the main goals of this project would be to research the articulation of the basic characteristics of the relations between man and space, in a dyachronical perspective. The aforementioned goals would be accomplished by combining the knowledge of topography and toponymy gained by analyzing the sources, and by reconstructing the external characteristic of the studied area. ]]></summary_en></project><project>
<id>13545</id><title_hr><![CDATA[Integrirana procjena odgovora akvatičkih organizama na izloženost metalima: ekspresija gena, bioraspoloživost, toksičnost i biomarkerski odgovori]]></title_hr><title_en><![CDATA[]]></title_en><user_id>12330</user_id><user_firstLast_name>Vlatka Filipović Marijić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-3220</code><acronim><![CDATA[BIOTOXMET]]></acronim><duration>08.10.2021 - 07.04.2026</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Interdisciplinarne prirodne znanosti, </scie_field_hr><scie_field_en>Interdisciplinary natural sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>865083</team_members_id><team_members_names><![CDATA[ Doktorand: Sara Šariri ]]></team_members_names><keywords_hr><![CDATA[Metali, probavilo riba, kukaši, unos metala hranom, bioindikatori, kalcificirane strukture, testovi toksičnosti, otpadne vode]]></keywords_hr><keywords_en><![CDATA[Metals, fish intestine, acanthocephalans, dietary metal uptake, bioindicators, calcified structures, toxicity testing, wastewaters]]></keywords_en><summary_hr><![CDATA[Procjena izloženosti akvatičkih organizama metalima uključuje primjenu indikatorskih organizama i tkiva, najčešće jetre i škrga riba, školjkaša i rakova, međutim još uvijek postoji potreba za pouzdanim i osjetljivim bioindikatorima, koji bi odražavali biorasploživu, a time i potencijalno toksičnu razinu metala te ukazivali na kratkoročne i dugoročne promjene. Iako je probavilo rijetko korišteno kao bioindikatorski organ, aktualna je spoznaja da je unos metala hranom u ribe jednako važan kao i unos vodom. Rijetki podatci o razinama metala u probavilu riba uglavnom se uspoređuju s razinama metala u crijevnih nametnika kukaša, koji akumuliraju metale učinkovitije od drugih indikatorskih organizama. Do sada nije poznata bioraspoloživost metala unesenih hranom, kao ni mehanizam vezanja metala u kukaša te se planira po prvi puta odrediti udio metabolički raspoložive razine metala u probavilu riba te ekspresija gena u probavilu riba i kukašima u različitim uvjetima izloženosti metalima. Istraživanje će se provesti na rijeci Krki, koja je zbog čiste krške vode, ali i ulijevanja industrijskih i komunalnih otpadnih voda, prikladan ekosustav koji omogućava praćenje mehanizma toksičnosti metala, njihove akumulacije te bioloških odgovora u organizama pod različitim utjecajem onečišćenja. Utjecaj na organizme procijenit će se mjerenjem biokemijskih i histopatoloških markera, kao i koncentracija metala u probavilu i mišiću potočne pastrve, kukašima te kalcificiranim strukturama (otolitima i ljuskama) koje ukazuju na dugoročnu izloženost metalima tijekom rasta riba. Uz nativne, eksperimentalni organizmi (alge, Daphnia) ukazat će na potencijalnu toksičnost riječne i otpadne vode provođenjem testova toksičnosti. Sveobuhvatna procjena ekološkog stanja uključivat će određivanje razina metala u vodi i sedimentu rijeke Krke i četiri pritoke te po prvi puta omjera izotopa 87Sr/86Sr, kao markera geoloških značajki.]]></summary_hr><summary_en><![CDATA[Although there are common indicator organisms and tissues used in metal exposure assessment, mostly liver and gills of fish, bivalves and crustaceans, we are still in need of reliable and sensitive bioindicators, which will reflect bioavailable and therefore, possible toxic metal level, but also short and long term metal changes in the aquatic environment. Although fish intestine was rarely used as bioindicator tissue, the current studies indicate that both diet- and waterborne metal uptake are of equal importance for native fish. Rare data on intestinal metal levels were mostly related to metal levels in fish intestinal parasites, acanthocephalans, which accumulate metals more effectively than other indicator organisms. So far, there is no data on dietary metal bioavailability and on mechanism of metal binding in acanthocephalans, so it is planned for the first time to estimate metabolically available metal fraction in fish intestine and gene expression in fish intestine and acanthocephalans under different metal exposure regimes. Research will be performed in the Krka River, as suitable ecosystem for evaluation of metal toxicity, accumulation and biological responses in organisms under different pollution impact, due to clean karst water but also industrial and municipal wastewater discharges. Organism responses will be estimated by biochemical and histopathological markers, as well as metal levels in brown trout intestine and muscle, acanthocephalans and calcified structures (otoliths, scales), which indicate long term metal exposure during fish growth. Besides native, experimental organisms (algae, Daphnia) will indicate possible toxicity of the river and wastewater by toxicity testing. Comprehensive evaluation of ecological state will include determination of metals in the water and sediment of the Krka River and four tributaries and for the first time 87Sr/86Sr isotope ratio, as a natural marker of geological characteristics.]]></summary_en></project><project>
<id>13546</id><title_hr><![CDATA[Nove građevne jedinke u supramolekulskom dizajnu složenih višekomponentnih molekulskih kristala temeljenih na halogenskim vezama]]></title_hr><title_en><![CDATA[]]></title_en><user_id>356</user_id><user_firstLast_name>Dominik Cinčić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-9523</code><acronim><![CDATA[HaloBond]]></acronim><duration>13.10.2021 - 12.10.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>858398</team_members_id><team_members_names><![CDATA[ Doktorand: Lidija Posavec ]]></team_members_names><keywords_hr><![CDATA[Halogenska veza, metaloorganski materijali, kokristali, supramolekulska kemija, mehanosinteza]]></keywords_hr><keywords_en><![CDATA[Halogen bond, metal-organic materials, cocrystals, supramolecular chemistry, mechanosynthesis]]></keywords_en><summary_hr><![CDATA[Halogenska veza je privlačna interakcija koja se intenzivno proučava u različitim područjima kemije, a ponajviše u kristalnom inženjerstvu. Za sustavno istraživanje halogenskih veza najčešće su primjenjivani organski sustavi s perhalogeniranim spojevima kao donorima halogenske veze, dok su najčešće korišteni akceptori organski spojevi koji sadrže različite funkcijske skupine s dušikom. Skupine s kisikom ili težim atomima kao akceptorima rjeđe su izučavane, a uključuju najviše spojeve sa sumporom te halogenima. Kao nastavak naših ranijih istraživanja u području kristalnog inženjerstva, kojima je uspostavljen preliminarni dizajn kokristala farmaceutskih spojeva temeljnih na halogenskoj vezi te prvi primjeri halogenske veze s teškim pniktogenima (P, As, Sb), ovaj projekt inovira dizajn i sintezu materijala temeljenih na halogenskim vezama te uključuje organsku, koordinacijsku i supramolekulsku kemiju. Projekt se sastoji od tri radne cjeline kojima je zajedničko izučavanje halogenskih veza, dizajn i sinteza: i) ionskih, ii) organskih te iii) metaloorganskih kokristala. Omogućit će: i) razjašnjavanje hijerarhije međumolekulskih interakcija u ionskim kristalima koji se temelje na halogenskoj vezi, ii) otkrivanje novih sintona halogenske veze te razumijevanje njihove fleksibilnosti, iii) istraživanje potencijala anorganskih i organskih aniona kao akceptora, iv) istraživanje potencijala kationskih vrsta kao donora i v) utvrđivanje potencijala težih pniktogena kao akceptora halogenske veze. Očekivani doprinos ovog projekta ponajviše je od fundamentalnog značaja za kristalno inženjerstvo kao i za eksperimentalnu i teorijsku supramolekulsku kemiju u čvrstom stanju. Značajni doprinosi bit će novi smjerovi za pouzdanu sintezu metaloorganskih materijala povezanih halogenskim vezama te u otvaranju novih mogućnosti korištenja halogenskih veza u dizajnu kokristala, višekomponentnih materijala od velikog interesa za razvoj lijekova, agrokemikalija i drugih funkcionalnih materijala.]]></summary_hr><summary_en><![CDATA[The halogen bond (X-bond) is emerging as an attractive interaction, intensely researched across different fields, and especially crystal engineering. Systematic studies of X-bonds are mostly performed using perhalogenated organic compounds as donors, using predominatly nitrogen-based acceptors. Studies with heavier atoms or oxygen as acceptors are less common, largely based on sulphur or halogens. As a continuation of our previous work in crystal engineering, which established preliminary designs for X-bonded pharmaceuticals and demonstrated the first examples of X-bonds to heavy pnictogen acceptors (P, As, Sb), this project will innovate the design and synthesis of materials based on X-bonds, by establishing ways to reliably combine coordination, covalent and supramolecular chemistry. The project is based on 3 work packages focusing on the design and synthesis of: i) ionic, ii) organic, and iii) metal-organic cocrystals. It will contribute by: i) elucidating the hierarchy of supramolecular interactions in X-bonded ionic crystals, ii) discovering new X-bonding synthons and understanding their flexibility, iii) investigating the potential of organic and inorganic anions as acceptors, iv) investigating the potential of cations as donors, and v) establishing the crystal engineering potential of heavy pnictogens as X-bond acceptors. Significant contributions will be new paths for reliable construction of metal-organic materials via X-bonds, and cocrystal-based routes for targeted synthesis of isostructural solids. The expected impact is in fundamental aspects of crystal engineering, as well as experimental and theoretical supramolecular chemistry of solids. The importance lies in opening new opportunities for using X-bonds in the design of cocrystals, i.e. multi-component materials of high interest in developing new pharmaceuticals, agrochemicals, and other functional advanced materials.]]></summary_en></project><project>
<id>13548</id><title_hr><![CDATA[Obnovljiva i otpadna toplina za kompetitivne toplinske rashladne mreže (Renewable and Waste Heat Recovery for Competitive District Heating and Cooling Networks -REWARDHeat)]]></title_hr><title_en><![CDATA[]]></title_en><user_id>13036</user_id><user_firstLast_name>Tomislav Pukšec</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-2378</code><acronim><![CDATA[]]></acronim><duration>20.10.2021 - 20.04.2026</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, </scie_field_hr><scie_field_en>Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>865155</team_members_id><team_members_names><![CDATA[ Doktorand: Josip Miškić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>13549</id><title_hr><![CDATA[Regulacija GLI koda u tumorima ovisnim o BRAF/NRAS mutacijama]]></title_hr><title_en><![CDATA[]]></title_en><user_id>712</user_id><user_firstLast_name>Petar Ozretić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-5821</code><acronim><![CDATA[GLIcode]]></acronim><duration>08.10.2021 - 07.04.2026</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>865071</team_members_id><team_members_names><![CDATA[ Doktorand: Josipa Čonkaš ]]></team_members_names><keywords_hr><![CDATA[Signalni put Hedgehog, BRAF, NRAS, melanom, GLI]]></keywords_hr><keywords_en><![CDATA[Hedgehog signaling, BRAF, NRAS, melanoma, GLI]]></keywords_en><summary_hr><![CDATA[Signalni put Hedgehog povezan je s nastankom raznih tumora, ali točni mehanizmi djelovanja još nisu u potpunosti razjašnjeni. Fokus ovog istraživanja su tumori s mutacijama u genima BRAF ili NRAS, te njihov odgovor na inhibiciju signalnog puta Hedgehog. BRAF i NRAS nekanonički aktiviraju sva tri proteina GLI, ali točan slijed i djelovanje ovih interakcija još nisu razjašnjeni. Ovim projektom planiramo odrediti točne transkripcijske mete proteina GLI1, GLI2 i GLI3 u melanomima s različitim genetičkim podlogama: mutacijom u BRAF, mutacijom u NRAS, ili bez mutacije u ova dva gena. Stoga ćemo prvo provesti analizu ChIP-seq kako bismo odredili točne transkripcijske mete ovih proteina. Nakon toga uklonit ćemo gene za svaki od tih proteina („knock-out“) i sekvencirati transkriptome tih staničnih linija. Nakon izrade „knock-out“ linija, testirat ćemo ih nizom testova kako bismo odredili ulogu svakog od tri proteina GLI u tumorima ovisnim o BRAF/NRAS mutacijama, te kako bismo razjasnili mehanizam njihovog djelovanja u melanomima. Kombiniranim tretmanima inhibitorima signalnog puta Hedgehog i specifičnim inhibitorima BRAF/NRAS, te izradom i testiranjam staničnih linija otpornih na te lijekove, pokazat ćemo postoji li pozitivan učinak za potencijalno liječenje melanoma. Sve ove analize pokazat će nam mogu li se proteini GLI ili njihovi ciljni geni koristiti kao potencijalni biomarkeri za melanom. Na kraju, u zadnjoj godini projekta, analizirat ćemo set kliničkih uzoraka na te potencijalne biomarkere, kako bismo procijenili njihovu moguću primjenu u klinici. Ukratko, ovim projektom u planu je kompletna analiza GLI koda u melanomima ovisnim o BRAF/NRAS mutacijama, od određivanja transkripcijskih meta i pronalaženja molekularnih mehanizama do potencijalne primjene u klinici.]]></summary_hr><summary_en><![CDATA[The Hedgehog signaling pathway has been implicated in development of various tumors, but the exact roles and molecular mechanisms are still not understood. The focus of this research are the tumors harboring BRAF of NRAS mutations, and their differential response to Hedgehog pathway inhibition. Both BRAF and NRAS non-canonically activate the three GLI proteins, but the activity and interplay of this interaction in still unclear. With this project we propose to determine the exact transcriptional targets of GLI1, GLI2 and GLI3 proteins in melanoma with different genetic backrounds, either harboring a BRAF mutation, a NRAS mutation, or no mutation in these two genes. For this purpose, we will first perform ChIP-seq to determine the transcriptional targets, then knock-out each of the three GLI proteins and sequence the transcriptomes of the knock-out cell lines. After the knock-outs have been generated, a series of cell assays will be performed to determine to role of each of the three GLI proteins in BRAF/NRAS dependant tumors, and to elucidate the mechanism of their action in melanoma. Combined treatments with Hedgehog inhibitors and specific BRAF/NRAS inhibitors, followed by generation and testing of resistant cell lines, will demonstrate if there is a potential benefit in the clinical management of melanoma. All these analyses will demonstrate whether GLI proteins or their transcriptional targets can be used as potential biomarkers for melanoma. Finally, in the final year of the project, a set of clinical samples will be analyzed for these potential biomarkers to determine their possible use in the clinic. In summary, this project plans a complete analysis of the GLI code in BRAF/NRAS dependant melanoma, from determining the transcriptional targets and finding molecular mechanisms, to potential translation to the clinic.]]></summary_en></project><project>
<id>13550</id><title_hr><![CDATA[Utjecaj valova vezanih uz otok na primarnu produkciju ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>2829</user_id><user_firstLast_name>Zrinka Ljubešić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-8430</code><acronim><![CDATA[ISLAND]]></acronim><duration>10.12.2021 - 09.12.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>865208</team_members_id><team_members_names><![CDATA[ Doktorand: Antonija Matek ]]></team_members_names><keywords_hr><![CDATA[valovi vezani uz otok, primarna produkcija, fizikalo-biološka interakcija, plankton, bentos]]></keywords_hr><keywords_en><![CDATA[island-trapped waves, primary production, physico-biological coupling, plankton, benthos]]></keywords_en><summary_hr><![CDATA[Valovi vezani uz otok (engl: Island-trapped waves ITWs) su tip valova vezanih uz obalu (engl: coastal-trapped waves CTWs), dobro poznat i značajan oceanografski fenomen koji utječe na vertikalne pomake piknokline, i time na  miješanje vodenog stupca, transport hranjivih tvari te na dinamiku primarne produkcije. Pretpostavljamo da je ITW glavni pokretač primarne produkcije u vrijeme stratifikacije u oligotrofnim vodama Lastovskog arhipelaga. Da bismo testirali ovu hipotezu, predlažemo interdisciplinarno istraživanje u kojemu će se koristiti razne metode i senzori sa ciljem povezivanja ITW s resupenzijom hranjivih soli i primarnom produkcijom. Dodana vrijednost predloženom projektu, te dodatna podrška za testiranje hipoteza je analiza bentičke zajednice koju će se napraviti pomoću ronioca i ROV-a. Dinamiku primarne produkcije povezat ćemo sa vremenski i prostorno gustim setom podataka dobivenih biogeokemijskim senzorima pričvršćenih uz podmorske litice Lastova (klorofil a, turbiditet, fotosinteska aktivna radijacija i hranjive soli) i usidrenog sustava Wirewalker – instrumenta koji profilira od dna do površine te mjeri brojna hidrografska i bio-optička svojstava mora. Neto primarna proizvodnja (NPP) izračunat će se iz dnevnih ciklusa oslabljenja radijacije čestica i koncentracije kisika. Odredit će se sastav zajednice i abundancija primarnih i sekundarnih producenata s više metoda (svjetlosna i elektronska mikroskopija, protočna citometrija, sekvencioniranje slijedeće generacije). Predloženo interdisciplinarno istražvanje će povezati primarnu produkciju sa ITW, te finu vremnesku i prostornu rezoluciju fizikalno kemijskih podataka sa bentičkom zajednicom što do sada nije bilo napravljen u ovdje predloženom obimu.]]></summary_hr><summary_en><![CDATA[Island-trapped waves (ITWs) are a special case of coastal-trapped waves (CTWs); a well-known oceanographic phenomenon. Vertical pycnocline movements related to CTWs impact vertical mixing, transport of nutrients and primary production. We hypothesize that ITWs fuel up the primary production in the stratification period in the oligotrophic waters of Lastovo archipelago. To test this hypothesis we propose an interdisciplinary research program, that will provide insights into the physical-biological coupling on much finer scale than achieved before; using biogeochemical sensors mounted to steep underwater cliffs of the island (chlorophyll a, turbidity, photosynthetic active radiation and nutrients) in addition to hydrographic sensors and a moored WireWalker - buoyant instrument platform clipped to a wire profiling from surface buoy to near the seafloor, equipped with various oceanographic sensors. In support of the high-resolution moored measurements, discrete ship-based sampling for nutrients, primary and secondary producers will also be performed, as well as continues analyses  of the state of the benthic community using photographic quadrants. Primary productivity will be assessed from diel cycles in bio-optical properties both from the Wirewalker, as well as from ship based measurements during the stratification and period of water column mixing. Observations that elucidate primary production dynamics will be augmented by high resolution records of temperature, light intensity, chlorophyll a and nutrients from sensors. To determine the primary and secondary producers multiple tools will be used (light and electron microscopy, flow-cytometry, NGS). With proposed interdisciplinary research we will link ITWs to NPP as well as the detailed physico-chemical high resolution data to benthic community, which has not been done before in this extent. ]]></summary_en></project><project>
<id>13552</id><title_hr><![CDATA[Zbrinjavanje mulja kroz proizvodnju energetskih kultura]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5606</user_id><user_firstLast_name>Neven Voća</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-9915</code><acronim><![CDATA[Mud4BioEnergy]]></acronim><duration>11.10.2021 - 11.10.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Biotehnologija, </scie_field_hr><scie_field_en>Biotechnology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Agronomski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Agriculture]]></institution_en><team_members_id>865134</team_members_id><team_members_names><![CDATA[ Doktorand: Ivan Brandić ]]></team_members_names><keywords_hr><![CDATA[Primjena mulja, energetske kulture, prinos, žetva, biogoriva]]></keywords_hr><keywords_en><![CDATA[Sludge application, energy crops,  yield,  harvest, biofuels]]></keywords_en><summary_hr><![CDATA[Prioritetna politika Europske unije jest da se mulj dobiven nakon pročistača otpadnih voda koristi na ekonomski optimalan način u poljoprivrednom sektoru te da se ukoliko je to moguće izbjegne njegovo spaljivanje. Zbrinjavanje mulja u poljoprivredi je definirano strogim propisima i direktivama koje nisu razdvojile njegovo korištenje u prehrambenoj ili neprehrambenoj proizvodnji. Postoje velike mogućnosti za napredak u isplativosti efikasne primjene mulja na tlo i to u količinama koje su veće od definiranih, bez ikakve opasnosti i mogućeg prodora štetnih tvari u okoliš. Naime, Pravilnikom o primjeni mulja u poljoprivrednoj proizvodnji u RH propisana je količina od najviše 1,66 tona suhe tvari mulja godišnje po hektaru poljoprivrednog zemljišta, bez obzira na vrstu poljoprivredne proizvodnje. Međutim, unatoč tim ograničenjima, kroz korištenje energetskih kultura postoji mogućnost obilnijeg korištenja mulja kao gnojiva. Procjene govore da bi se na taj način poljoprivredne površine višestruko reducirale u smislu intenzivnijeg zbrinjavanja mulja u poljoprivredi. Isto tako, idealno bi se korištenje mulja uklopilo upravo u proizvodnju energetskih kultura, koje bi bile oslobođene problema sa zdravstvenom reputacijom proizvoda. Ovom metodom mogla bi se iskoristiti tla lošije kvalitete i nepovoljnih agroklimatskih uvjeta koja ne mogu konkurirati u konvencionalnoj proizvodnji hrane. Zbog svega navedenog, kao idealne energetske kulture se nameću sterilna rizomatska trava Miscanthus x giganteus i biljka iz porodice sljezova Sida hermaphrodita. Cilj ovoga istraživanja analiza je biomase navedenih energetskih kultura, gnojenih različitim količinama mulja iz pročistača otpadnih voda, jednako u energetskom i ekološkom smislu. Isto tako, veliki izazov u uzgoju energetskih kultura leži u pravilnom odabiru datuma žetve, a samim time i smjeru korištenja biomase za potrebe proizvodnje različitih biogoriva.]]></summary_hr><summary_en><![CDATA[EU priority policy is a feasible utilization of sludge from wastewater treatment plant in the agricultural sector while avoiding its incineration. Sludge disposal in the agricultural sector is defined by strict regulations and directives which do not distinguish its utilization in food or non-food production. There is a great potential for improvement in terms of efficient sludge application to the soil, in larger quantities, without any danger or possible breaking of harmful substances into the environment. Regulations on the sludge application in agricultural production in Croatia is regulated by the amount of up to 1.66 t of sludge DM/year per ha of arable land, regardless of the type of agricultural production. However, despite these limitations, through the use of energy crops, there is a possibility of plentiful sludge use as a fertilizer. According to estimations, arable land will be greatly reduced in terms of intensive sludge management in agriculture in this way. Ideally, the use of sludge would fit right in the production of energy crops, which would be exempt from the problems with the healthy reputation of the product. Furthermore, this method could be used in lower quality soils and unfavorable climatic conditions that cannot compete with conventional food production. Consequently, sterile grass Miscanthus x giganteus and Mallow family plant Sida hermaphrodita are imposed as deal energy crops. The aim of this research is the analysis of those energy crops, fertilized with various quantities of sludge from the wastewater treatment plant. Also, a major challenge in energy crops growing lies in the proper selection of the harvesting date, as well as in choosing the optimal biofuel production pathway. ]]></summary_en></project><project>
<id>13554</id><title_hr><![CDATA[ODRŽIVA GRADNJA NASUTIH PLAŽA – GRADNJA NOVIH I POVEĆANJE KAPACITETA POSTOJEĆIH]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4885</user_id><user_firstLast_name>Dalibor Carević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-9108</code><acronim><![CDATA[BEACHEX]]></acronim><duration>07.10.2021 - 06.10.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Građevinarstvo, </scie_field_hr><scie_field_en>Civil engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Građevinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Civil Engineering]]></institution_en><team_members_id>865068</team_members_id><team_members_names><![CDATA[ Doktorand: Hanna Miličević Miličević ]]></team_members_names><keywords_hr><![CDATA[dohrana plaža, nasipavanje plaža, erozija plaža, utjecaj nasipavanja na okoliš, utjecaj nasipavanja na biocenozu,baza podataka plaža ]]></keywords_hr><keywords_en><![CDATA[beach nourishment, beach filling, beach erosion, enviromental impact of filling, beach database]]></keywords_en><summary_hr><![CDATA[Hrvatske plaže su pod pritiskom turizma s jedne strane gdje se teži povećanju kapaciteta plaža te utjecaja klimatskih promjena s druge strane koje povećavaju erozijski potencijal olujnih valova. Na strateškoj razini, Hrvatska provodi osnovne mjere s ciljem učinkovitog upravljanja plažama ali u tom procesu nedostaje tehnička podrška. Upravo definiranje tehničke podrške za potrebe dugoročnog nasipavanja postojećih i novih žala u Hrvatskoj s minimalnim utjecajem na okoliš je cilj ovog projekta. U okviru projekta planira se izraditi sveobuhvatna baza lokacija (podataka) na kojima se vrši nasipavanje u svrhu povećanja kapaciteta plaža. Na bazi opsežnog terenskog mjerenja, planira se rasvijetliti morfološke procese na nasutim plažama u uvjetima jadranske valne klime te razviti jednostavan inženjerski alat za tehničke proračune (SHINGLE model). Utjecaj na okoliš, odnosno podmorsku biocenozu, će se istražiti kroz pet ronilačkih pregleda na plažama na kojima se vrši redovito nasipavanje. Primjenom numeričkog modeliranja definirat će se tehničke mjere potrebne da bi se dugoročno minimizirao gubitak materijala iz nasutih žala te mjere za umanjenje utjecaja klimatskih promjena. Edukacija relevantnih dionika (tehničko osoblje županija, gradova i općina) će se osigurati kroz provedbu dviju radionica u primorskim županijama. Diseminacija znanstvenih rezultata će se obaviti kroz publikaciju četiri znanstvena rada te pet konferencijskih izlaganja.]]></summary_hr><summary_en><![CDATA[Beaches in Croatia are under the pressure due to tourism development from one side which tends to growth the beach capacities and from the other side due to influence of climate changes which enlarge erosion potential of storm waves. At the strategic level, Croatia implements basic measures to effectively manage beaches but, in that process, technical support lacks. Definition of the technical support for the needs of long-term nourishing of the existing and filing of the new beaches in Croatia with minimal environmental impact is the goal of this project. Within the project it is planned to create a comprehensive database of sites where filling is used to apply along the Croatian coast. Based on the extensive field measurements, it is planned to research the morphological processes on the gravel beaches in wave conditions of the Adriatic Sea and to develop a simple engineering tool for technical calculations (SHINGLE model). The impact on the environment, i.e. on the underwater biocenosis, will be investigated through five dive examinations at beaches where regular nourishment takes place. Applying numerical modeling, the technical measures needed to minimize the loss of material from the beaches in long-term conditions will be defined and measures to mitigate the impact of climate changes. Education of relevant stakeholders (technical staff of counties, cities and municipalities) will be ensured through the implementation of two workshops in coastal counties. Dissemination of scientific results will be carried out through the publication of four scientific papers and five conference presentations.]]></summary_en></project><project>
<id>13556</id><title_hr><![CDATA[Hrvatska rukopisna kultura: djela, pisari, zbirke]]></title_hr><title_en><![CDATA[]]></title_en><user_id>7050</user_id><user_firstLast_name>Vladimir Rezar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-5028</code><acronim><![CDATA[HeRKUL]]></acronim><duration>09.12.2021 - 08.12.2025</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filologija, </scie_field_hr><scie_field_en>Philology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>865254</team_members_id><team_members_names><![CDATA[ Doktorand: Leon Cvitić Cvitić ]]></team_members_names><keywords_hr><![CDATA[rukopis, znanost o rukopisima, pisar, kolekcionarstvo, ranonovovjekovlje, hrvatska kultura]]></keywords_hr><keywords_en><![CDATA[manuscript, manuscript studies, scribe, collecting, early modern period, Croatian culture]]></keywords_en><summary_hr><![CDATA[Važnost ovog istraživanja leži u činjenici da je većina bogate hrvatske rukopisne književne baštine (procjenjujemo je na oko 10000 kodeksa) još uvijek neopisana i neproučena, dok je znanost o rukopisima, disciplina koja se u stranim filologijama formira posljednjih desetljeća, kod nas još u začecima te joj je potrebno postaviti teorijski okvir. Za proučavanje hrvatske rukopisne kulture odabrani su primjeri rukopisa i rukopisnih zbirki na temelju kojih će se iznijeti novi uvidi o materijalnim i nematerijalnim aspektima rukopisne kulture (fizičke značajke, postupak izrade rukopisa, suodnos autografa i prijepisa te tiskanih izdanja, djelovanje prepisivača, priređivača i kolekcionara, čitateljske prakse, promet rukopisa, predaja teksta itd.). Odabrani su rukopisi književnih djela na dvama najzastupljenijim jezicima, hrvatskom i latinskom, pokrivena sva razdoblja u rasponu od početka 15. do 2. pol. 19. stoljeća, kao i važnije kulturne sredine: dalmatinske komune, Dubrovnik i Zagreb s okolicom. Koristit ćemo se kodikološkom, paleografskom, tekstološkom, lingvističkom, književnom, historiografskom i kulturnopovijesnom metodologijom. Cilj je projekta ne samo dopuniti spoznaje o našoj rukopisnoj kulturi nego i koncipirati suvremeni teorijski pristup rukopisnoj građi te otvoriti put daljnjim istraživanjima. Planiramo izraditi kodikološki opis 15 rukopisa i 8 rukopisnih zbirki; proučiti povijesnu i usustaviti suvremenu kodikološku terminologiju te izraditi njezin pojmovnik; sastaviti registar domaćih i inozemnih zbirki s našim rukopisima, s popisom pripadajućih kataloga; rukopise prikazati na web-stranici; pripremiti 4 kritička izdanja; kompleksnosti i specifičnosti hrvatske rukopisne kulture predstaviti na međunarodnoj znanstvenoj sceni. Očekivani rezultati uključuju monografije, izvorne i pregledne znanstvene članke (od kojih neke u uglednim inozemnim časopisima), edukativne prezentacije, radionice, znanstveni skup, izlaganja rezultata na domaćim i inozemnim skupovima.]]></summary_hr><summary_en><![CDATA[The importance of this research lies with the fact that the majority of the manuscript literary heritage of Croatia (estimated at around 10,000 codices) has still not been studied and properly described. Manuscript studies, a discipline which has achieved prominence in the international scholarship in the last decades, is still taking shape in Croatia, lacking a proper theoretical and terminological framework. The research will be based on the manuscripts that can offer new insights into the material and nonmaterial aspects of the Croatian manuscript culture: physical aspects of manuscripts; process of making manuscripts; interrelationship between an autograph, a copy and a printed edition; scribal and editorial work, collectors; reading practices; circulation of manuscripts; transmission of the text etc. The research will cover manuscripts of literary works composed in Croatian and Latin, in the period between the early 15th and late 19th centuries, in the the Dalmatian cities, Dubrovnik and Zagreb. We will use codicological, palaeographical, textological, linguistic, literary, historiographical and culture-historical methodologies. The goal of the project is to fill the gaps in knowledge of Croatian manuscript culture and to conceptualize a modern theoretical approach to the manuscript sources and thus lay a groundwork for further research. We plan to prepare codicological descriptions of 15 manuscripts and 8 manuscript collections; study the historical and systematize the modern codicological terminology, prepare a glossary of terms; arrange a registry of national and foreign collections of Croatian manuscripts; present the manuscripts at the project web-page; prepare four critical editions; present the complexities and specificities of Croatian manuscript culture to the international scholarship. The expected results include monographs, original scholarly articles and overviews, workshops, educational presentations, a scholarly conference and presentations.]]></summary_en></project><project>
<id>13558</id><title_hr><![CDATA[Hlađenje atoma frekventnim češljem]]></title_hr><title_en><![CDATA[]]></title_en><user_id>22599</user_id><user_firstLast_name>Neven Šantić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-6278</code><acronim><![CDATA[CoolComb]]></acronim><duration>01.04.2023 - 31.03.2027</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut za fiziku]]></institution_hr><institution_en><![CDATA[Institute of Physics in Zagreb]]></institution_en><team_members_id>865160</team_members_id><team_members_names><![CDATA[ Doktorand: Johnn Toro ]]></team_members_names><keywords_hr><![CDATA[lasersko hlađenje, hladni atomi, optički frekventni češalj, rubidij, magneto-optička stupica]]></keywords_hr><keywords_en><![CDATA[laser cooling, cold atoms, optical frequency comb, rubidium, magneto-optical trap]]></keywords_en><summary_hr><![CDATA[Uvođenje laserskog hlađenja u atomsku i molekulsku fiziku prije tri desetljeća započelo je revoluciju koja nastavlja redefinirati krajolik eksperimenata koji nam pomažu bolje razumijeti kvantni svijet. Korištenje uskopojasnih kontinuiranih lasera za kontrolu temperature atoma evoluiralo je tijekom godina te postiglo puno šire područje primjene nego što je prvobitno bilo predviđeno, brzo pomičući granice znanstvenog razvoja kroz impresivne pothvate u području ultrahladnih atoma. Ipak, unatoč značajnim napretcima, preostaju važne praznine unutar područja, a jedna od najizraženijih je naša nemogućnost da laserski hladimo i zarobljavamo vodik, (gotovo sve) molekule te najrasprostranjenije atome organske kemije: ugljik, kisik i dušik.Cilj ovog projekta je stvoriti alate koji će nam omogućiti širenje primjene laserskog hlađenja na raznolike vrste atoma i molekula. Konkretno, koristit ćemo optički frekventni češalj za izravno lasersko hlađenje i zarobljavanje atoma rubidija (Rb) te demonstrirati istodobno hlađenje dva Rb izotopa. Kako bi postigli taj cilj, okupili smo iskusan tim istraživača - stručnjake za lasersku fiziku, hladne atome, spektroskopiju frekventnim češljem te teorijsko modeliranje međudjelovanja lasera i atoma - koji će (i) teorijski modelirati radijativnu silu na atome uzrokovanu frekventnim češljem i odrediti optimalne parametre češlja za hlađenje, (ii) dizajnirati i izgraditi novi pikosekundni Ti:safir laser sa spregnutim modovima pumpan plavim diodama, (iii) stabilizirati i postići kontrolu nad spektrom frekventnog češlja lasera te (iv) primijeniti frekventni češalj za izravno hlađenje i zarobljavanje Rb atoma i istodobno hlađenje dvije vrste atoma.Naša uspješna demonstracija potvrdit će frekventni češalj kao novi alat za lasersko hlađenje šireg raspona molekula i atoma koje do sada nije bilo moguće hladiti, omogučujući tako napredak u područjima kao što su kontrolirana kemija, astrofizika, precizna mjerenja te kvantne informacije i simulacije.]]></summary_hr><summary_en><![CDATA[The introduction of laser cooling to atomic and molecular physics three decades ago started a revolution that continues to redefine the landscape of feasible experiments which help us better understand the quantum world. The use of narrow-band continuous-wave lasers to control the motional temperature of atoms has evolved over the years to have much broader applications than originally anticipated, rapidly pushing forward the frontiers of scientific development through impressive efforts in the field of ultracold atoms. Yet despite these substantial advances, there remain important gaps in the field, one of the most conspicuous being our inability to laser cool and trap hydrogen, (almost any) molecules, or the most prevalent atoms in organic chemistry: carbon, oxygen, and nitrogen.The aim of this project is to create the tools that will allow us to extend laser cooling to more diverse species of atoms and molecules. Specifically, we will use an optical frequency comb for direct laser cooling and trapping of rubidium (Rb) atoms, and demonstrate simultaneous comb cooling of two Rb isotopes. To achieve this goal, we have gathered an experienced team of researchers – experts in laser physics, cold atoms, frequency comb spectroscopy, and theoretical modeling of laser-atom interactions – who will (i) theoretically model the comb-induced radiative force on atoms and define optimal comb parameters for cooling, (ii) design and build a novel blue-diode-pumped Ti:sapphire picosecond mode-locked laser, (iii) stabilize and gain control over its frequency comb spectrum, and (iv) apply the comb for direct cooling and trapping of Rb atoms and simultaneous dual-species cooling.Our successful demonstration will validate the frequency comb as a new tool for laser cooling a broader range of molecules and so far un-coolable species thus allowing breakthroughs in fields as diverse as controlled chemistry, astrophysics, precision measurements, and quantum information and simulation.]]></summary_en></project><project>
<id>13559</id><title_hr><![CDATA[Functionalised Tomato Products - FunTomP, ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>469</user_id><user_firstLast_name>Anet Režek Jambrak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-6411</code><acronim><![CDATA[]]></acronim><duration>14.10.2021 - 13.10.2025</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Prehrambena tehnologija, </scie_field_hr><scie_field_en>Food technology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Food Technology and Biotechnology]]></institution_en><team_members_id>865190</team_members_id><team_members_names><![CDATA[ Doktorand: Josipa Dukić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>13560</id><title_hr><![CDATA[Razvoj nove generacije snack proizvoda namijenjenih potrošačima s posebnim prehrambenim potrebama primjenom tehnologija 3D tiskanja ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>19413</user_id><user_firstLast_name>Nikolina Čukelj Mustač</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-8880</code><acronim><![CDATA[]]></acronim><duration>02.11.2021 - 01.11.2025</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Prehrambena tehnologija, </scie_field_hr><scie_field_en>Food technology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Food Technology and Biotechnology]]></institution_en><team_members_id>26629</team_members_id><team_members_names><![CDATA[ Doktorand: Kristina Radoš ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>13561</id><title_hr><![CDATA[Nove metode u suzbijanju štetnika masline primjenom biljnih hlapivih tvari (LoVeFly) KK.01.1.1.04.0002]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4400</user_id><user_firstLast_name>Elda Vitanović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-1355</code><acronim><![CDATA[]]></acronim><duration>01.09.2021 - 01.06.2026</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Institut za jadranske kulture i melioraciju krša]]></institution_hr><institution_en><![CDATA[Institute for Adriatic Crops and Karst Reclamation in Split]]></institution_en><team_members_id>865038</team_members_id><team_members_names><![CDATA[ Doktorand: Filipa Burul ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>13562</id><title_hr><![CDATA[Dinamika Aktivnih i Rotirajućih KONstrukcija]]></title_hr><title_en><![CDATA[]]></title_en><user_id>25884</user_id><user_firstLast_name>Neven Alujević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-3859</code><acronim><![CDATA[DARS]]></acronim><duration>01.04.2022 - 31.03.2026</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, </scie_field_hr><scie_field_en>Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>865360</team_members_id><team_members_names><![CDATA[ Doktorand: Srećko Arandia-Krešić ]]></team_members_names><keywords_hr><![CDATA[Vibracije, Akustika, Vibroakustika, Automatska regulacija vibracija, Vibracije rotirajućih konstrukcija]]></keywords_hr><keywords_en><![CDATA[Vibration, Acoustics, Vibroacoustics, Active vibration control, Vibration of rotating structures ]]></keywords_en><summary_hr><![CDATA[U posljednjih dvadesetak godina vibroakustička kvaliteta tehničkih proizvoda postaje iznimno važna za kompetitivnost gospodarstava zemalja EU kao i za blagostanje njihovih građana. Primjerice, zagađenje bukom u prometu drugi je po redu uzrok povećanja smrtnosti građana EU. Njegovanje relevantnih inženjerskih disciplina i ciljana izobrazba novih stručnjaka u tom području jednako je važna i za razvoj hrvatskog gospodarstva i društva.Projektom DARS obrađuju se dvije znanstveno i tehnologijski zahtjevne istraživačke teme u području buke i vibracija.Prva tema je automatska regulacija buke i vibracija, s posebnim fokusom na razvoj nove klase aktivnih metamaterijala kroz koje se transmisija zvuka može suzbijati selektivno. Trenutno gorući istraživački problem u ovom području je kako poremetiti princip recipročnosti koji inače općenito vrijedi za linearne akustičke medije i linearno-elastična tijela. Projektom DARS razvit će se i provjeriti aktivna ćelija metamaterijala kako bi se demonstrirala mogućnost narušavanja principa recipročnosti transmisije zvuka kroz meta-materijalnu prepreku. Druga tema obuhvaća vibracije rotirajućih deformabilnih konstrukcija kao što su osovinski vodovi brodova ili automobilski pneumatici. Kod takvih konstrukcija postoji potreba za boljim razumijevanjem i kvalitetnijim opisom fizikalnih mehanizama koji uzrokuju pojavu rotirajućih formi vibriranja i bifurkacija prirodnih frekvencija. Kroz provedbu projekta DARS razvit će se i provjeriti fizikalno jasni modeli za analizu vibracijskog ponašanja takvih konstrukcija.Dvije istraživačke teme osnova su za dvije doktorske disertacije pa će se dvoje mladih istraživača profilirati kroz stjecanje novih znanja uz upotrebu najmodernijih istraživačkih metoda i opreme. Mladi istraživači će se integrirati u aktivnu i produktivnu istraživačku grupu iskusnu u području buke i vibracija stječući nove vještine i povećavajući svoju zapošljivost. Za potrebe provedbe projekta opremit će se vibroakustički laboratorij.]]></summary_hr><summary_en><![CDATA[In the last two decades noise and vibration quality of engineering products has become increasingly important for the competitiveness of industries of the EU countries and for the well-being of their citizens. For example, transportation noise is the second most deadly environmental pollutant in the EU. Nourishing the relevant engineering disciplines and a targeted education of new experts in the area is equally relevant for the development of Croatian economy and society. DARS project deals with two scientifically and technologically challenging research topics in the area of sound and vibration. The first topic is the active control of sound and vibration, in particular the development of a new class of active metamaterials that are able to selectively reduce sound transmission through them. A currently hot problem here is how to disrupt the well-known reciprocity principle in acoustic and structural media. Within the scope of DARS project an active metamaterial cell will be developed and validated in order to demonstrate the feasibility of non-reciprocal sound transmission through it.The second topic is the dynamics of rotating flexible structures, such as ship power transmission lines or automotive tyres. In such structures, there is a need to fully understand and describe the physical mechanisms of the generation of rotating modes and the bifurcation of natural frequencies with rotation speed. Within the scope of DARS project, physically transparent models that capture the relevant phenomena will be developed and validated.The two research trajectories will enable two PhD students to benefit from training through research using the most recent methods and equipment, boosting their expertise and employability. The young researchers will be immersed into an active and productive research group of scientists experienced in the area of sound and vibration. A laboratory for experimental vibroacoustics necessary for the project execution will be judiciously equipped.]]></summary_en></project><project>
<id>13563</id><title_hr><![CDATA[Procjena fotosintetske aktivnosti i fotozaštitnog potencijala TROL-FNR razdjelnice]]></title_hr><title_en><![CDATA[]]></title_en><user_id>455</user_id><user_firstLast_name>Hrvoje Fulgosi</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-2018</code><acronim><![CDATA[FUTURE PLANT]]></acronim><duration>15.10.2021 - 15.04.2026</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>865086</team_members_id><team_members_names><![CDATA[ Doktorand: Ena Dumančić ]]></team_members_names><keywords_hr><![CDATA[elektronski transport, redoks regulacija fotosinteze, ROS, brzi A-Ci odgovor RACiR, NPQ]]></keywords_hr><keywords_en><![CDATA[electron transport chain, redox regulation of photosynthesis, ROS, rapid A-Ci response RACiR, NPQ]]></keywords_en><summary_hr><![CDATA[Fotosinteza je nedvojbeno najvažniji autotrofni proces na Zemlji. Ona ne samo da osigurava primarnu proizvodnju hrane, već je zaslužna za glavnu izmjenu plinova u atmosferi. Biljke fotosintezom troše ugljični dioksid, a ispuštaju kisik neophodan za život velikog broja vrsta. Za to im je potrebna svjetlost i voda. S obzirom da nisu pokretne, biljke su razvile brojne mehanizme zaštite od prekomjernog osvjetljenja, kao i od drugih stresora. Regulacija protoka energije u fotosintetskom lancu predmet je brojnih istraživanja, a zbog ubrzanih klimatskih promjena interes za ovakva istraživanja je u porastu. Završni prijenos fotosintetskih elektrona na molekulu NADP+ vrši enzim feredoksin NADP+ oksidoreduktaza (FNR). U biljnim kloroplastima FNR se veže na tilakoidne membrane putem proteina TROL (Thylakoid RhOdanase-Like) kojeg smo prethodno otkrili i karakterizirali. Interakcija TROL-FNR je dinamička i igra važnu ulogu u razdiobi fotosintetskih elektrona između procesa koji čuvaju i pretvaraju energiju i onih koji je, kada je u suvišku, rasipaju. FNR vezan na TROL efikasno katalizira linearni prijenos energije i sintezu NADPH, a kada je slobodan FNR sudjeluje u vrlo brzom procesu iskorištavanja elektrona koji sprečava stvaranje reaktivnih kisikovih jedinki (ROS). U ovom ćemo projektu istražiti fotosintetski potencijal TROL-FNR razdjelnice korištenjem najsuvremenije RACiR tehnike mjerenja izmjene plinova. Istražit ćemo i ulogu razdjelnice u zaštitnim procesima nefotokemijskog gašenja fluorescencije klorofila a (NPQ), propagaciji i detoksifikaciji ROS te sintezi fotozaštitnih molekula.]]></summary_hr><summary_en><![CDATA[Photosynthesis is arguably the most important autotrophic process on Earth. It provides primary food production and is responsible for the major atmospheric gas exchange. Plants driving photosynthesis consume CO2 and release oxygen that is pivotal for the life of many species. For this, plants require light and water. Being sessile organisms, plants have evolved numerous protective mechanisms against high-light and other stressors. Regulation of the photosynthetic energy flow is in the focus of modern plant biology research and is gaining importance due to rapid climate changes. Final photosynthetic electron transfer to the NADP+ is performed by the enzyme ferredoxin NADP+ oxidoreductase (FNR). In plant chloroplasts FNR binds to thylakoid membranes via protein TROL (Thylakoid RhOdanase-Like), which was previously discovered and characterized by our group. TROL-FNR interaction is dynamic and plays important role in photosynthetic electron partitioning between energy-conserving and -dissipating processes. TROL-bound FNR effectively catalyzes linear electron transfer and NADPH synthesis, while soluble FNR participates in the rapid electron dissipation, which effectively prevents ROS propagation. In this project, we shell research photosynthetic potential of the TROL-FNR bifurcation by using state-of-the-art RACiR gas exchange measurements. Further, we shell investigate the role of this bifurcation in the protective processes of the non-photochemical quenching of chlorophyll a fluorescence (NPQ), ROS propagation, and synthesis of photoprotective molecules.]]></summary_en></project><project>
<id>13564</id><title_hr><![CDATA[&#39;&#39;Održiva proizvodnja bioplina zamjenom kukuruzne silaže poljoprivrednim energetskim kulturama&#39;&#39;]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5600</user_id><user_firstLast_name>Vanja Jurišić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-4422</code><acronim><![CDATA[]]></acronim><duration>18.10.2021 - 17.10.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Agronomski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Agriculture]]></institution_en><team_members_id>865124</team_members_id><team_members_names><![CDATA[ Doktorand: Karlo Špelić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>13565</id><title_hr><![CDATA[Fizičko modeliranje ponašanja konstrukcija za sanaciju klizišta u uvjetima statičkih i seizmičkih djelovanja]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4285</user_id><user_firstLast_name>Vedran Jagodnik</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-4152</code><acronim><![CDATA[ModLandRemSS]]></acronim><duration>02.11.2022 - 01.11.2026</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Građevinarstvo, </scie_field_hr><scie_field_en>Civil engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Građevinski fakultet u Rijeci]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Civil Engineering]]></institution_en><team_members_id>866215</team_members_id><team_members_names><![CDATA[ Doktorand: Davor Marušić ]]></team_members_names><keywords_hr><![CDATA[klizište, fizički model, modeliranje, sanacija, konstrukcija, monitoring]]></keywords_hr><keywords_en><![CDATA[landslide, physical model, modelling, remediation, structure, monitoring]]></keywords_en><summary_hr><![CDATA[Fizičko modeliranje klizišta na temelju analiza ponašanja umanjenih modela započeto je krajem 1980-tih kad je istraživano ponašanje tokova tla i fluidifikacije kliznog materijala u umanjenom fizičkom modelu (također poznatom pod nazivom flume ili flume test). Glavni zadatak fizičkog modeliranja klizišta u zadnjih 25 godina bilo je istraživanje pokretanja, kretanja i akumulacije brzih klizišta nalik tečenju uzrokovanih infiltracijom vode u kosinu. Brojni modeli klizišta i istraživanja mogu se podijeliti u dvije glavne grupe vezane na osnovne pokretače klizišta: oborine i potrese. Postojeće studije ponašanja sanacijskih konstrukcija na klizištima u fizičkim modelima vrlo su rijetke. Predloženi Projekt uključiti će istraživanja ponašanja različitih konstrukcije primijenjenih za sanacije klizišta u fizičkim modelima umanjenih klizišta u statičkim i dinamičkim uvjetima gdje statički uvjeti pretpostavljaju uvjete klizišta pokrenutih oborinama, a dinamički uvjeti uvjete klizišta izazvanih potresima. Promatranje gibanja u fizičkom modelu klizišta provesti će se mrežom senzora za mjerenje pomaka, pritisaka, sila i pornih pritisaka i inovativnom fotogrametrijskom opremom koja uključuje terestrički laserski skener i infracrvenu kameru. Umanjene sanacijske konstrukcije izraditi će se 3D printerom što će omogućiti precizne umanjene elemente konstrukcija. Izmjereni parametra iz fizičkog modela biti će uključeni u 3D numeričke simulacije. Rezultati iz oba modela omogućiti će bolje razumijevanje ponašanja konstrukcija za sanaciju klizišta. Metode analiza stabilnosti koje se koriste za projekte sanacije klizišta u inženjerskoj praksi još uvijek su grube i rezultiraju odabirom konzervativnih sanacijskih konstrukcija. Zbog tog razloga, rezultati istraživanja mogli bi predstavljati osnovu za nove pristupe racionalnog projektiranja sanacijskih konstrukcija za klizišta u inženjerskoj praksi.]]></summary_hr><summary_en><![CDATA[Physical modelling of landslide using scaled landslide models behaviour was established at the end of 1980s when in a scaled physical model (flume or flume test) behaviour of flowslide and liquefaction of sliding material were investigated. The main task of landslide physical modelling in last 25 years was research of initiation, motion and accumulation of fast flow like slides caused by infiltration of surface water in a slope. The numerous established landslide physical models and researches can be divided in two main groups related to landslide main triggering factors: rainfall and earthquakes. The existing studies of landslide remedial construction behaviour using physical modelling are very rare. The proposed Project will encompass researches of behaviour of different construction applied for landslide remediation in physical models of scaled landslides in static and dynamic conditions where static conditions imply conditions for rainfall triggered landslides and dynamic conditions imply conditions for earthquake induced landslides. Observations of landslide movements in a physical model will be carried out by sensor network for measuring displacements, pressures, forces and pore pressures and innovative photogrammetric equipment including terrestrial laser scanner and infrared camera. Scaled remedial constructions will be constructed by 3D printer that will enable precise scaled construction elements. The measured parameters from physical model will be included in 3D numerical simulation. The results of both physical and numerical modelling will enable better understanding of landslide remedial construction behaviour. Methods of stability analysis used for landslide remediation design in engineering practice are still very rough and result with selection of conservative remedial constructions. For that reason, research results would represent the base for new approaches to the rational landslide remedial construction designing in engineering practice.]]></summary_en></project><project>
<id>13566</id><title_hr><![CDATA[Renesansa teorije uzorkovanja]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6991</user_id><user_firstLast_name>Davor Petrinović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-6215</code><acronim><![CDATA[SamplingRenaissance]]></acronim><duration>06.12.2021 - 05.12.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>865244</team_members_id><team_members_names><![CDATA[ Doktorand: Dorotea Potoč Potoč ]]></team_members_names><keywords_hr><![CDATA[post-uzorkovanje, sažimajuće očitavanje, hibridni podatkovni modeli, hibridne metode obrade, svjetlosno polje, 3D rekonstrukcija, PET]]></keywords_hr><keywords_en><![CDATA[post-sampling, compressive sensing, hybrid data models, hybrid processing methods, light field, 3D reconstruction, PET]]></keywords_en><summary_hr><![CDATA[Uzorkovanje i rekonstrukcija signala sačinjavaju središnji dio digitalne obrade signala (DSP). Teorem uzorkovanja predstavlja vezu između kontinuiranog i diskretnog svijeta u modernim elektroničkim uređajima, pametnim telefonima, kamerama te medicinskoj opremi. Sažimajuće očitavanje (CS) tehnika je koja se oslanja na konačnu frekvenciju inovacije kako bi se smanjio broj mjerenja potrebnih za statistički pouzdanu rekonstrukciju.  Brz napredak u ovom području istraživanja predstavlja renesansu teorije uzorkovanja, prvenstveno zbog svog značaja za znanstvenu zajednicu koja se bavi digitalnom obradom signala.Naše istraživanje doprinosi ovom izazovnom području u nekoliko aspekata. Nova paradigma post-uzorkovanja temeljit će se na hibridnim kontinuirano-diskretnim modelima podataka i metodama obrade. Navedeno će omogućiti kontinuiranu obradu signala na digitalnom računalu bez diskretnih aproksimacija temeljenih na uzorcima. Osim toga, uvest će se novi optimalni i adaptivni pristupi mjerenju. Kako bi se prevladali određeni nedostaci redukcije dimenzionalnosti u sažimajućem očitavanju, uvest će se eksploratorna mjerenja.U novije vrijeme pristup temeljen na dubokom učenju rezultirao je brzim napretkom metoda nadziranog učenja. Stoga ćemo primijeniti metode strojnog učenja kako bismo postigli visoku kvalitetu i brzu CS rekonstrukciju signala. Rezultati našeg istraživanja donijet će poboljšanja u praktičnim primjenama kao što su snimanje iz višestrukih pogleda, snimanje svjetlosnog polja, 3D rekonstrukcija te medicinsko snimanje, odnosno pozitronska emisijska tomografija (PET). Snimanje svjetlosnog polja nadilazi mogućnosti klasične fotografije te omogućuje naknadnu obradu slika, primjerice promjenu gledišta, digitalno refokusiranje te virtualnu promjenu otvora blende. Korištenjem slika iz višestrukih pogleda, slika svjetlosnog polja te PET slika, naše istraživanje omogućit će točniju 3D rekonstrukciju.]]></summary_hr><summary_en><![CDATA[Signal sampling and reconstruction are a central part of the digital signal processing (DSP) - the sampling theorem provides a bridge between the continuous and discrete-time world in modern electronic devices, smartphones, cameras and medical equipment. Compressive sensing (CS) is a technique that relies on finite rate of innovation in order to reduce the number of measurements needed for statistically reliable reconstruction. Rapid advances in this research area bring a renaissance of the sampling theory, mostly due to its significance to the DSP community. Our research contributes to this challenging field in several aspects. New post-sampling paradigm will be based on hybrid continuous-discrete data models and processing methods. It will enable continuous signal processing on a digital computer without the discrete approximation based on samples. Moreover, novel optimal and adaptive measurement approaches will be introduced. Exploratory measurements will be proposed to overcome certain drawbacks of the CS dimensionality reduction. Recently, a deep learning based approach resulted in a rapid advance of supervised learning methods. We will apply machine learning methods to achieve high quality and fast CS reconstruction. Applications that will benefit from our research results are multi-view and light field imaging, 3D reconstruction and medical imaging, namely positron emission tomography (PET). Light field imaging goes beyond the conventional photography and enables powerful post-capture capabilities, such as change of viewpoint, digital refocusing, and virtual change of aperture. Our research will enable more accurate 3D reconstruction from multi-view, light field and PET images.]]></summary_en></project><project>
<id>13567</id><title_hr><![CDATA[Razvoj sustava zasnovanih na učećim agentima za poboljšanje upravljanja prometom u gradovima]]></title_hr><title_en><![CDATA[]]></title_en><user_id>2616</user_id><user_firstLast_name>Edouard Ivanjko</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-8159</code><acronim><![CDATA[DLASIUT]]></acronim><duration>01.11.2021 - 31.10.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet prometnih znanosti]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Transport and Traffic Sciences]]></institution_en><team_members_id>865173</team_members_id><team_members_names><![CDATA[ Doktorand: Željko Majstorović ]]></team_members_names><keywords_hr><![CDATA[inteligentni transportni sustavi,upravljanje prometom,višeagentni sustavi,strojno učenje,mikroskopske simulacije prometa,umrežena i autonomna vozila]]></keywords_hr><keywords_en><![CDATA[inteligent transport systems, traffic control, multi-agent systems, machine learning, microscopic traffic simulation, connected and autonmous vehicles]]></keywords_en><summary_hr><![CDATA[Današnja gradska okruženja sklona su dnevnim zagušenjima zbog visoke prijevozne potražnje. Razvoj sustava upravljanja prometom zasnovanih na strojnom učenju privukao je interes za stvaranje inteligentnih sustava s mogućnošću poboljšanja učinkovitosti prometne mreže. Primjena strojnog učenja u upravljanju prometom u gradskim sredinama sklona je problemu dimenzionalnosti. Na ponašanje sustava upravljanja utječe broj promatranih prometnih parametara koji opisuju okolinu u kojem upravljački sustav djeluje. Povećanje broja parametara uzrokuje eksponencijalno povećanje mogućeg prostora stanja i akcija čineći pronalazak optimalnog upravljačkog zakona u razumnom vremenu gotovo nemogućim. Skalabilnost istog prostora postaje vrlo važna. Također je potrebno steći povjerenje u rad sustava upravljanja zasnovanog na učećim agentima i u nepredviđenim situacijama. Upravljački zakon koji djeluje dobro u svim relevantnim prometnim stanjima važniji je od superiornih performansi u nekim stanjima. Stoga je podešavanje takvih sustava za značajne promjene u prijevoznoj potražnji vrlo problematičan ili čak neizvediv zadatak za operatere bez pomoći računala. Glavna snaga projekta DLASIUT je predloženi okvir za učenje i struktura sustava upravljanja prometom zasnovanog na učećim agentima sposobna naučiti optimalni upravljački zakon iz mikroskopskih simulacija s realističnim modelima gradske cestovne mreže. Dodatno, bit će dodana podrška za umrežena i autonomna vozila (CAV) koristeći ih kao dodatni upravljački izlaz koji osigurava primjenjivost sustava upravljanja u budućim miješanim prometnim tokovima s klasičnim i CAV vozilima. Dubinsko testiranje korištenjem realističnih simulacijskih modela i strukturiranih simulacija s gledišta tehnologije prometa radi identificiranja lošeg ponašanje sustava upravljanja, znatno će poboljšati trenutno znanje o takvim sustavima zasnovanim na strojnom učenju. Korist za stanovnike gradova je bolje upravljanje prometom te smanjenje zagušenja i emisija vozila.]]></summary_hr><summary_en><![CDATA[Today’s urban environments are prone to daily congestions due to dense traffic. The development of Machine Learning (ML) based traffic control systems for such environments gathered interest to create intelligent systems with the potential to improve the existing transport network efficiency. Applying ML in control of complex urban environments is prone to the curse of dimensionality. The controller behavior is influenced by the number of observed traffic parameters describing the environment in which it acts. Rising the number of parameters causes an exponential increase of possible state-action space, making it nearly impossible to find an optimal control policy in a reasonable time. The scalability of the same space becomes very important. It is also necessary to gain trust or confidence in the ML control system’s performance in unforeseen situations. Having a control policy that performs well in all relevant traffic states is more important than superior performance in some states. Thus, tuning of such systems for significant transport demand changes is very problematic or even infeasible for operators without computer support. The main benefit of the project DLASIUT is the proposed learning framework and structure of an agent-based traffic controller capable of learning the optimal control policy from microscopic simulations containing realistic models of a real-world urban road network. Additionally, support to Connected and Autonomous Vehicles (CAVs) will be added using them as an extra control output ensuring the applicability in future mixed traffic flows containing classic vehicles and CAVs. In-depth testing using realistic simulation models and Structured Simulation Framework from transport technology point of view to identify possible poor controller behavior will improve the state of the art of ML-based traffic controllers. The benefit for the citizens of urban environments is better traffic management and reduction of congestions and vehicle emissions.]]></summary_en></project><project>
<id>13569</id><title_hr><![CDATA[Ruske književne transformacije od 1990. do 2020. ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5143</user_id><user_firstLast_name>Jasmina Vojvodić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-2040</code><acronim><![CDATA[Transform ]]></acronim><duration>01.11.2021 - 31.10.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filologija, </scie_field_hr><scie_field_en>Philology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>865119</team_members_id><team_members_names><![CDATA[ Doktorand: Petra Grebenac Grebenac ]]></team_members_names><keywords_hr><![CDATA[suvremena ruska književnost, transformacije, poetički sustav od 1990. do 2020., prijelazno književno razdoblje, književni pravci i poetičke škole]]></keywords_hr><keywords_en><![CDATA[contemporary Russian literature, transformations, poetic system from the 1990s to 2020, transitory literary period, literary movements and schools]]></keywords_en><summary_hr><![CDATA[Svi pregledi i teorijski uvidi suvremene ruske književnosti govore da je trenutno područje istraživanja recentne ruske književnosti disperzirano, bez jasnih poetičkih odrednica. U suvremenoj humanistici, napose rusistici i šire slavistici, nedostatna su sintetska istraživanja. Projektni prijedlog ruskih književnih transformacija od 1990. do 2020. nastoji znanstveno i analitički prevladati disparatnost i nepreglednost u dosadašnjim istraživanjima, registrirati, usustaviti i opisati postojeće pravce i tendencije u rečenom razdoblju te ih analitički obrazložiti. Projektni prijedlog ruskih književnih transformacija od 1990. do 2020. ima jasan teorijski okvir koji se temelji na postavljenoj hipotezi o važnosti početne točke (1990. godina) koja označava kulturno-povijesnu i društveno-političku prekretnicu i završne (2020. godina) kao završetak desetljeća i našu najbližu suvremenost, što odgovara književnim tendencijama trenutka, „sada i ovdje“. Pretpostavljamo da na temelju dosadašnjih saznanja i budućih istraživanja možemo jasno pokazati promjene u poetičkom sustavu koje se događaju od 1990-ih  prema 2000-im godinama te novi poetički zaokret u vremenu od 2010. godine naovamo. Projektni prijedlog ima lokalnu i globalnu relevantnost. Lokalnu jer nas zanimaju kretnja ruske književnosti u kontekstu specifičnih ruskih književnih i kulturnih tradicija, a globalnu jer ćemo svoja istraživanja povezati s globalnim tendencijama razvoja književnog polja te time ponuditi daljnje smjernice u proučavanju suvremene ruske književnosti kao svjetskog fenomena. Takva cjelovita istraživanja ruske književnosti još nema ni u hrvatskoj, ruskoj niti europskoj (svjetskoj) rusistici (slavistici).]]></summary_hr><summary_en><![CDATA[All surveys and critical studies state that studies into recent Russian literature are dispersed, with no poetic determinants. There is lack of research synthesis in the contemporary humanities, especially Russian and Slavic studies. This project proposal focusing on Russian literary transformations in the 1990-2020 period aims at solving divergence and unstructured nature of the current research with scientific and analytical means by identifying, classifying, describing and explaining analytically the existent trends and tendencies in the stated period. The project proposal focusing on Russian literary transformations in the 1990-2020 period has a clear theoretical framework based on the presumption about the importance of the starting point (1990) because it signals a cultural, historical and political milestone, while the importance of the final year, i.e. 2020 and the end of the decade, is important because it is the closest point to contemporaneity in line with the most recent literary trends of “the now and here”. We believe that, based on the previous findings and future studies, we will be able to clearly show changes in the poetic system from 1990 to 2010, as well as a new poetic turning point in the period from 2010 onwards. The project is important for local and global community. Locally, because we are interested in the trends in Russian literature in the context of specific Russian literary and cultural traditions, and globally, because we intend to combine our research with global trends in the development of literary studies. This will enable us to offer further guidelines for studying contemporary Russian literature as a world phenomenon. Such a comprehensive research of Russian literatures has not been performed by Croatian, Russian or European (global) Russian and Slavic studies scholars.]]></summary_en></project><project>
<id>13573</id><title_hr><![CDATA[Matematička analiza i numeričke metode za višefazne sustave vođene difuzijom]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5872</user_id><user_firstLast_name>Mario Bukal</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-6341</code><acronim><![CDATA[MANDphy]]></acronim><duration>01.12.2021 - 30.11.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>865249</team_members_id><team_members_names><![CDATA[ Doktorand: Matija Livaić ]]></team_members_names><keywords_hr><![CDATA[višefazni sustavi, nelinearna difuzija, unakrsna difuzija, homogenizacije, numeričke metode koje čuvaju strukturu]]></keywords_hr><keywords_en><![CDATA[multiphase systems, nonlinear diffusion, cross-diffusion, homogenization, structure preserving numerical schemes]]></keywords_en><summary_hr><![CDATA[Projekt se bavi teorijskim aspektima i numeričkom analizom parcijalnih diferencijalnih jednadžbi koje opisuju sustave s više faza, a javljuju se u fizici, biologiji i geologiji. Točnije, bavit ćemo se parcijalnim diferencijalnim jednadžbama koje opisuju: (i) dinamiku granice između dviju odvojenih faza (npr. granica zrak / tekućina ili tekućina / tekućina u tankim viskoznim fluidima, granica u sustavima spinova itd.) i (ii ) dinamiku gustoće ili volumnih udjela faza (npr. nemješive tekućine u poroznom mediju, viševrsni modeli u biologiji, kemiji itd.). U svim tim jednadžbama &#39;&#39;pokretačka sila&#39;&#39; dinamike proizlazi iz difuzijske strukture jednadžbe: degenerirana difuzija u obliku prostornih derivacija četvrtog reda (i) i sustav nelinearnih difuzijskih i unakrsnih difuzijskih jednadžbi (ii). Motivacije za proučavanje takvih sustava proizlaze iz brojnih i raznovrsnih primjena, što mi ocrtavamo kroz četiri scenarija: (1) fluktuacija granice u  sustavima spinova, (2) dinamika tankog viskoznog fluida s toplinskim efektima, (3) sanacija nafte u spremnicima ugljikovodika i (4) viševrsni biološki naliči za obradu otpadnih voda. Naši glavni ciljevi su analiza postojanja fizikalno relevantnih slabih rješenja, analiza njihovih kvalitativnih svojstava (dugoročno ponašanje, sebi-sličnost rješenja, eksplozija ili prekid itd.), izvod homogeniziranih (makroskopskih) modela za modele s višeskalnom prirodom poput modela  bioloških naliča za obradu otpadnih voda, i konačno, konstrukcija pouzdanih numeričkih metoda, koje čuvaju strukturu jednadžbi i u stanju su dohvatiti kvalitativna opažanja. Uspješna provedba ovog projekta doprinijet će najnovijim saznanjima u području istraživanja i bit će dodana vrijednost zajednici primijenjene matematike u Hrvatskoj.]]></summary_hr><summary_en><![CDATA[The project deals with theoretical aspects and numerical analysis of partial differential equations, which describe systems with multiple phases arising in physics, biology and geology. More precisely, we are interested in partial differential equations describing: (i) dynamics of the interface between two separated phases (e.g. air/liquid or liquid/liquid interface in thin viscous films, interface in spin systems, etc.), and (ii) dynamics of densities or volume fractions of system phases (e.g. immiscible fluid flows in porous medium, multispecies models in biology, chemistry, etc.). In all these equations the &#39;&#39;driving force&#39;&#39; of the dynamics emanates from the diffusion structure of the equation: degenerate diffusion in terms of fourth-order spatial derivatives (i), and systems of nonlinear diffusion and cross-diffusion equations (ii). Motivations for studying such systems arise from numerous and versatile applications and we render it through four application scenarios: (1) interface fluctuations in spin systems, (2) dynamics of thin viscous fluids with thermal effects, (3) oil recovery in hydrocarbon reservoirs, and (4) multispecies biofilms for wastewater treatment. Our main goals are to undertake the existence analysis of physically relevant weak solutions, analysis of their qualitative properties (long-time behaviour, self-similarities, blow-up or rupture, etc.), derivation of homogenized (macroscopic) models for models of multiscale nature like the biofilm model for wastewater treatment, and finally, to construct reliable structure preserving numerical schemes, which are able to capture qualitative observations. Successful implementation of this project will contribute to the state of the art in the research field and will be an added value to the Croatian applied mathematics community.]]></summary_en></project><project>
<id>13574</id><title_hr><![CDATA[Tekstilni materijali za povećanu udobnost u sportu]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4820</user_id><user_firstLast_name>Goran Čubrić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-4746</code><acronim><![CDATA[TEMPO]]></acronim><duration>02.11.2021 - 02.11.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Tekstilna tehnologija, </scie_field_hr><scie_field_en>Textile technology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Tekstilno-tehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Textile Technology]]></institution_en><team_members_id>865132</team_members_id><team_members_names><![CDATA[ Doktorand: Antonija Petrov ]]></team_members_names><keywords_hr><![CDATA[pletivo, funkcionalizacija, svojstva, udobnost, starenje, sportska odjeća, termografija, algoritam]]></keywords_hr><keywords_en><![CDATA[knitted fabric, functionalization, properties, comfort, aging, sportswear, thermography, algoritm]]></keywords_en><summary_hr><![CDATA[Kako zahtjevi krajnjih korisnika za proizvodnjom sportske odjeće s poboljšanim performansama rastu, misija znanstvenika da dizajniraju inovativne materijale postaje imperativom. Unutar projekta TEMPO okupljeni su znanstvenici različitih ekspertiza (dizajn materijala i vrednovanje svojstava, odjevno inženjerstvo, ljudski faktori i računalno modeliranje). Njihova je namjera međusobno se povezati i iskoristiti različite kompetencije kako bi proveli istraživanje koje je usmjereno na: (i) projektiranje inovativnih tekstilnih materijala (ii) optimalnih svojstava s (iii) dugotrajnom funkcionalnošću (iv) za personaliziranu odjeću, a sve podržano (v.) adekvatnim računalnim modelima. U svrhu mehaničke funkcionalizacije pletenih struktura, bit će projektirani i proizvedeni različiti uzorci. Temeljem vrednovanja strukturnih parametara, fizikalno-mehaničkih svojstava i svojstava koja određuju udobnost, provest će se optimizacija struktura te će biti razvijeni modeli algoritama strojnog učenja. Daljnji naglasak bit će na razvoju i validaciji protokola starenja materijala u različitim okruženjima, istraživanje svojstava materijala i definiranje algoritama za predviđanje funkcionalnosti proizvoda uslijed starenja. Termografija će se koristiti za mjerenje sportske odjeće u različitim okruženjima i poslužit će kao osnova za dizajn personalizirane sportske odjeće koja će poboljšati učinak sportaša. Predstavnici tekstilne industrije moći će koristiti rezultate istraživanja projekta TEMPO kako bi pronašli niše u proizvodnji prilagođene specifičnim potrebama pojedinaca. Rezultati istraživanja povećat će udobnost i funkcionalnost sportske odjeće, a razvijeni modeli moći će se primijeniti u izradi materijala i odjeće za različite ciljne skupine korisnika.]]></summary_hr><summary_en><![CDATA[As demands of end-users for sportswear with improved performance increase, the mission of scientists to design innovative materials for improved comfort becomes an imperative. Within the TEMPO project are gathered scientists with different core expertise, i.e. knitted fabric design and properties evaluation, clothing engineering, human factors and computational modelling. Their intention is to link with each and take advantage of different scientific backgrounds to start research that would be focused towards: (i.) design of innovative textile materials with (ii) optimal and (iii.) long-lasting properties (iv.) for personalized clothing and all supported by (v.) adequate computational modelling. For the purpose of mechanical functionalization of fabrics, various samples will be produced. Structural parameters, physical-mechanical and comfort properties will be measured and finally, structures will be optimized considering the obtained results and developed models of machine learning algorithms. Further emphasis will be on developing and validating protocols for materials aging in different environments, investigation of fabric properties and defining algorithms for the prediction of product functionality affected by aging. The thermography will be used for measurement of sportswear in different environment and it will serve as the basis for design of personalized sportswear that will enhance the performance of athlete.  In terms of TEMPO&#39;s outcomes, the representatives of textile industry will be able to use the research results to find niches in production geared to the specific needs of individuals. The research results will enhance the comfort and functionality of sportswear, and the developed models will have potential to be applied in fabrication of materials and clothing for different target groups of users.]]></summary_en></project><project>
<id>13575</id><title_hr><![CDATA[Molekularna raznolikost virusa Epstein-Barr]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4080</user_id><user_firstLast_name>Snježana Židovec Lepej</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-7036</code><acronim><![CDATA[MRVEB / MDEBV]]></acronim><duration>01.09.2021 - 01.09.2025</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Klinika za infektivne bolesti "Dr Fran Mihaljević", Zagreb]]></institution_hr><institution_en><![CDATA[Clinic for Infective Diseases "dr. Fran Mihaljević", Zagreb]]></institution_en><team_members_id>865045</team_members_id><team_members_names><![CDATA[ Doktorand: Marija Rozman ]]></team_members_names><keywords_hr><![CDATA[virus Epstein-Barr, virologija, molekularna raznolikost, sekvenciranje, infekcijska mononukleoza]]></keywords_hr><keywords_en><![CDATA[Epstein-Barr virus, virology, molecular diversity, sequencing, infectious mononucleosis]]></keywords_en><summary_hr><![CDATA[Epstein-Barr virus (EBV) ili humani herpesvirus 4 je ubikvitarni vlrus koji pripada porodici Herpesviridae. Akutna EBV infekcija može se prezentirati kao infekcijska mononukleoza, dok je latentna infekcija ovim virusom povezana s nastankom malignih bolesti. Specifični antivirusni lijekovi te cjepivo protiv EBV-a za sada nisu dostupni. Literaturni podatci o molekulamoj raznolikosti EBV-a i povezanosti genetske varijabilnosti virusa s patogenezom različitih bolesti vrlo su oskudni. Cilj ovog istraživanja je analizirati distribuciju genotipova, podtipova i genskih varijanti podtipova EBV-a u osoba s infekcijskom mononukleozom i malignim bolestima te istražiti moguću kliničku značajnost raznolikosti ovog virusa. Glavne hipoteze ovog istraživanja su: (1) zastupljenost genskih varijanti EBV-a s karakterističnim obrascima nukleotidnih promjena na razini gena EBNA-1, EBNA-2, LMP-1, Zp i BLLF1 u bolesnika s infekcijskom mononukleozom i u osoba s malignim bolestima je različita te (2) molekularna raznolikost EBV-a povezana je s težinom kliničkog tijeka infekcijske mononukleoze. Molekularna raznolikost EBV-a na razini odabranih gena analizirat će se primjenom populacijskog kao i dubinskog sekvenciranja, u svrhu otkrivanja koinfekcija s rijetkim molekularnim varijantama virusa. Metodom direktnog sekvenciranja u stvarnom vremenu optimizirat će se metoda analize cjelokupnog genoma ovog virusa. Predloženi projekt značajno će unaprijediti postojeća znanja o molekularnoj raznolikosti EBV-a na razini genotipova, podtipova i genskih varijanti virusa. Istraživanje molekularne raznolikosti ovog virusa u infekcijskoj mononukleozi i malignim bolestima povezanim s EBV-om omogućit će pručavanje moguće povezanosti između varijabilnsoti pojedinih virusnih gena i relevantnih kliničkih parametara. Nova znanja o molekularnoj raznolikosti EBV-a mogla bi značajno pridonijeti razvoju novih generacija cjepiva protiv EBV-a te boljem razumijevanju patogeneze bolesti povezanih s ovim virusom. ]]></summary_hr><summary_en><![CDATA[Epstein-Barr vlrus (EBV) or human herpesvirus 4 (HHV-4) is a ubiquitous virus belonging to the family Herpesviridae. Acute EBV infection is assoctated with development of infectious mononucleosis. Latent EBV infection is associated with development of malignancies. Specific antiviral drugs as well as EBV vaccines are currently not available. Literature data on EBV molecular diversity and association between viral genetic variations and pathogenesis of various diseases associated with this virus are limited. The aim of this study is to analyse EBV genotypes, subtypes and subtype genetic variants in patients with infectious mononucleosls and malignant diseases associated with EBV and to investigate the possible clinical significance of EBV genetic diversity. The main hypotheses of this study are: (1) the frequency of EBV characteristic combinations of variants in EBNA-1, EBNA-2, LMP-l, Zp and BLLF1 genes in patients with infectious mononucleosis and malignant diseases is different and (2) EBV molecular diversity in patients with infectious mononucleosis is associated with the clinical severity of disease. Molecular diversity of selected EBV genes will be analysed by population-based and ultra-deep sequencing probably leading to the more extensive analysis of co-infections with rare viral variants. Direct DNA sequencing in real time will be used for the whole genome analysis of EBV. The project is expected to significantly contribute to the knowledge on EBV molecular diversity by characterising viral genotypes, subtypes and subtype variants. EBV molecular diversity in infectious mononucleosis and malignant diseases will be considered in the context of the clinical presentation of diseases. Extensive analysls of EBV molecular diversity might significantly contribute to the development of EBV vaccines and improved understanding of the pathogenesis of disseases assoclated with EBV. ]]></summary_en></project><project>
<id>13576</id><title_hr><![CDATA[Znanstveni centar izvrsnosti za reproduktivnu i regenerativnu medicinu &#39;&#39;Reproduktivna i regenerativna medicina - istraživanje novih platformi i potencijala&#39;&#39;]]></title_hr><title_en><![CDATA[]]></title_en><user_id>7705</user_id><user_firstLast_name>Siniša Volarević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-6379</code><acronim><![CDATA[]]></acronim><duration>02.11.2021 - 01.11.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Medicine]]></institution_en><team_members_id>865200</team_members_id><team_members_names><![CDATA[ Doktorand: Katarina Budić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>13578</id><title_hr><![CDATA[Primjena pepela iz biomase radi unaprjeđenja poljoprivredne proizvodnje i plodnosti tala ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>20684</user_id><user_firstLast_name>Gabrijel Ondrašek</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-1592</code><acronim><![CDATA[]]></acronim><duration>29.09.2021 - 28.09.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Agronomski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Agriculture]]></institution_en><team_members_id>865047</team_members_id><team_members_names><![CDATA[ Doktorand: JELENA HORVATINEC ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>13579</id><title_hr><![CDATA[Regulacija endocitoze na velikoj skali pomoću IQGAP proteinima srodnih proteina IqgC i IqgD]]></title_hr><title_en><![CDATA[]]></title_en><user_id>12535</user_id><user_firstLast_name>Vedrana Filić Mileta</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-9726</code><acronim><![CDATA[RegEndIqCD]]></acronim><duration>08.12.2021 - 18.02.2027</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>865233</team_members_id><team_members_names><![CDATA[ Doktorand: Anja Privara ]]></team_members_names><keywords_hr><![CDATA[endocitoza na velikoj skali, IQGAP, RasGAP, Ras GTPaze, aktinski citoskelet, Dictyostelium]]></keywords_hr><keywords_en><![CDATA[large-scale endocytosis, IQGAP, RasGAP, Ras GTPases, actin cytoskeleton, Dictyostelium]]></keywords_en><summary_hr><![CDATA[Endocitoza na velikoj skali je endocitoza velikih volumena koja je neovisna o klatrinu, a vođena je aktinskim citoskeletom. Pojam skupno opisuje unos čestica ili fagocitozu i neselektivan unos velikih količina tekućine ili makropinocitozu. Za jednostanične organizme poput amebe Dictyostelium endocitoza na velikoj skali je ekskluzivan način hranjenja, dok je za stanice metazoa samo jedan od nekoliko, iako ne preferiran način unosa hranjivih tvari. Međutim, stanice sisavaca koriste obje vrste endocitoze na velikoj skali za druge fiziološke funkcije. Najbolji primjer su stanice imunološkog sustava koje koriste i fagocitozu i makropinocitozu za uklanjanje apoptotskih stanica i patogena iz tkiva te za pretraživanje izvanstanične tekućine na prisutnost stranih antigena. Endocitoza na velikoj skali povezana je i s nekim patološkim stanjima poput neurodegenerativnih bolesti, ateroskleroze i raka. Cilj ovog projekta je istražiti ulogu dva IQGAP proteinima srodna proteina, IqgC i IqgD, u regulaciji endocitoze na velikoj skali u organizmu Dictyostelium, koji je postao vodeći model u istraživanju makropinocitoze. Naši prethodni rezultati identificirali su IqgC kao negativni regulator Ras aktivnosti tijekom endocitoze na velikoj skali u fazama stvaranja endosoma. Međutim, daljnji preliminarni podaci sugeriraju da IqgC ima dodatne uloge tijekom sazrijevanja endosoma, vjerojatno putem drugih interaktora. Naš cilj je razjasniti ove funkcije testiranjem njegovih interakcija s fosfolipidima i određivanjem mehanizma njegove regrutacije na membranu. Drugi dio projekta usredotočit će se na biološke uloge IqgD. Naši preliminarni podaci pokazuju kortikalnu lokalizaciju IqgD, uključujući makropinosome. Ova lokalizacija, uz prisustvo domene koja veže aktin, snažno sugerira mehanističku ulogu IqgD u makropinocitozi putem regulacije aktinskog citoskeleta. Cilj je identificirati izravne interaktore IqgD i odrediti na koji način on regulira endocitozu na velikoj skali.]]></summary_hr><summary_en><![CDATA[Large-scale endocytosis is clathrin-independent, actin-driven bulk endocytosis. The term collectively describes particle uptake or phagocytosis and nonselective bulk uptake of fluid or macropinocytosis. For unicellular organisms like amoeba Dictyostelium, large-scale endocytosis is an exclusive way of feeding, while for metazoan cells it is one of several, not preferred, pathways of nutrient uptake. However, mammalian cells use both types of large-scale endocytosis for other physiological functions, besides feeding. The best example are cells of immune system that use both phagocytosis and macropinocytosis for removal of apoptotic cells and pathogens from tissues and to scan extracellular fluids for the presence of foreign antigens. Large-scale endocytosis is also linked to several pathological conditions like neurodegenerative diseases, atherosclerosis and cancer. This project aims to investigate the role of two IQGAP-related proteins, IqgC and IqgD, in regulation of large-scale endocytosis in Dictyostelium, which has become the leading model in macropinocytosis research. Our previous results identified IqgC as a negative regulator of Ras activity during large-scale endocytosis in stages of endosome formation. However, further preliminary data suggest that IqgC plays additional roles during endosome maturation, probably via interactors other than Ras. We aim to elucidate these functions by tackling its phospholipid interactions and by determining requirements for its membrane recruitment. The second part of the project will focus on biological roles of IqgD. Our preliminary data show cortical localization of IqgD, including macropinosomes. This localization, along with the presence of an actin-binding domain in its sequence, strongly suggests mechanistic role for IqgD in macropinocytosis via regulation of actin cytoskeleton. Our goal is to identify direct binding partners of IqgD and determine how it regulates large-scale endocytosis.]]></summary_en></project><project>
<id>13580</id><title_hr><![CDATA[Gubici uslijed vrtložnih struja u otvorenoj jezgri transformatora]]></title_hr><title_en><![CDATA[]]></title_en><user_id>328</user_id><user_firstLast_name>Martin Dadić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-9723</code><acronim><![CDATA[GOJTRA]]></acronim><duration>21.07.2021 - 20.07.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>865060</team_members_id><team_members_names><![CDATA[ Doktorand: Mario Filipašić ]]></team_members_names><keywords_hr><![CDATA[Naponski transformatori velike snage, laminirana otvorena jezgra, vrtložne struje, gubici, metoda konačnih elemenata]]></keywords_hr><keywords_en><![CDATA[power voltage transformer, laminated open core, eddy currents, losses, finite element method]]></keywords_en><summary_hr><![CDATA[Naponski transformatori velike snage (kombinacija energetskih i mjernih transformatora) imaju rastući tržišni potencijal kako pri napajanju vlastite potrošnje tako i u elektrifikaciji udaljenih područja. Jedinstveni hrvatski koncept takvih transformatora s otvorenom jezgrom se već dokazao na svjetskom tržištu. Za daljnji uspjeh tog koncepta nužno je stalno unapređivanje postupaka za projektiranje i konstrukciju otvorenih jezgara. Gubici u jezgri su temeljni parametar pri projektiranju jezgre, a posebno su značajni gubici uslijed vrtložnih struja. Proračun tih gubitaka u zatvorenoj jezgri složenoj od niza lamela od magnetskog lima se istražuje i unapređuje već dugi niz godina. Najčešće se inducirane struje i gubici  određuju na temelju izračunate raspodjele magnetskog toka. Zbog vrlo nepovoljnog omjera dimenzija (debljina lima manja od milimetra, širina od nekoliko desetaka milimetara, a visina od nekoliko metara), te izrazito nehomogene raspodjele gustoće magnetskog toka pri krajevima jezgre rezultati tih istraživanja nisu primjenjivi za otvorene jezgre. Uz geometriju modela, ključni podatak za izračun gubitaka jesu karakteristike magnetskog materijala. One su izrazito nelinearne, a njihova dostupnost u zadovoljavajućoj točnosti je jako ograničena.  U okviru ovog istraživanja će  se:•	razviti teorijska podloga za numerički proračun raspodjele gustoće magnetskog toka i vrtložnih struja u otvorenim jezgrama;•	izraditi algoritmi za proračun i ugraditi u  programski paket za proračun vrtložnih struja i gubitaka u otvorenoj jezgri naponskog transformatora velike snage;•	verificirati rezultati proračuna usporedbom s mjerenjima na više modela jezgri u tvrtki  u Končar - Mjerni transformatori;•	razviti uređaj za automatizirano mjerenje nelinearnih karakteristika feromagnetskih materijala u velikoj točnosti.]]></summary_hr><summary_en><![CDATA[Power voltage transformers (combination of instrument and power transformer) are an expanding product niche, both for auxiliary power and rural electrification applications. Unique Croatian concept of such transformers with the open core is already successful in the global market.  Continuous improvement of procedures for design and construction of open cores is necessary for further market success. Losses in the core are a fundamental parameter in the design and eddy current losses are particularly important. Calculation of these losses in closed cores built of magnetic laminations has been researched and developed for many years. Most frequently, induced currents and losses are determined based on calculated distribution of magnetic flux. Results of these researches cannot be applied to open cores because of adverse ratio of dimensions (thickness of lamination is less than one millimeter; width of the core is several centimeters and height is a few meters) and extremely inhomogeneous distribution of the magnetic flux density at open ends of the core. Necessary data for calculation of losses are magnetic characteristics of material. They are extremely nonlinear and   their accession in acceptable precision is very limited. Aims of this research are:•	development of theoretical basis for numerical computation of magnetic flux density distribution and eddy currents in open cores;•	creation of computation algorithms and programming of a package for computation of eddy currents and losses in open core of power voltage transformer•	verification of calculation results by comparison to measurements on models of cores in the firm Končar – Instrument transformers•	development of an automated system for measuring of nonlinear magnetic characteristics of ferromagnetic materials in high precision.]]></summary_en></project><project>
<id>13581</id><title_hr><![CDATA[Reorganizacija sučelja između ranih endosoma i endosomalnog reciklirajućeg odjeljka]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6883</user_id><user_firstLast_name>Hana  Mahmutefendić Lučin</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-2168</code><acronim><![CDATA[CREERC]]></acronim><duration>08.11.2021 - 07.11.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Medicine]]></institution_en><team_members_id>865202</team_members_id><team_members_names><![CDATA[ Doktorand: Barbara Radić ]]></team_members_names><keywords_hr><![CDATA[citomegalovirus, odjeljak za sklapanje virusnih čestica, rani endosomi, endosomalni reciklirajući odjeljak, ubikvitinilacija]]></keywords_hr><keywords_en><![CDATA[cytomegalovirus, viral assembly compartment, early endosomes, endosomal recycling compartment, ubiquitination]]></keywords_en><summary_hr><![CDATA[Biogeneza cVAC (engl. cytoplasmic virion assembly compartment) predstavlja važan, i još nerazjašnjen problem za razumijevanje biologije herpesvirusa. U ovom projektnom prijedlogu ćemo proučavati najranije faze reorganizacije mambranskih organela koje nazivamo preAC (engl. pre-assembly compartment). Ovaj istraživački projekt predstavlja nastavak i  produbljenje našeg prethodnoga rada i fokusira se na stanične mehanizme koje koristi mišji citomegalovirus (MCMV)  na sučelju između ranih endosoma i endosomalnog reciklirajućeg odjeljaka (EE-ERC), odnosno mjestu za koje pretpostavljamo da predstavlja inicijacijski korak cVAC biogeneze. U tu svrhu, MCMV može ciljati (1) domaćinske efektore koji reguliraju procese sortiranja i recikliranja na EE-ERC sučelju, (2) Rab10 i njegove partnere, regulatorne proteine koji kontroliraju EE-ERC prometovanje, i (3) procese ubikvitinilacije koji kontroliraju endosomalno recikliranje, a djeluju prema principu reostata. Ovi potencijalni učinci MCMV djelovanja predstavljaju tri cilja ovog projektnog prijedloga. Kako bismo ih ispunili testirat ćemo skoro 50 staničnih efektora i regulatora na EE-ERC sučelju i njihovu ulogu u nastanku preAC. Stanice će biti inficirane divljim tipom i različitim MCMV rekombinantama, a domaćinski proteini će biti analizirani knock-down (siRNA, inhibitori) i knock-out eksperimentima (CRISPR-Cas9). Nastanak preAC će se pratiti konfokalnom mikroskopijom i rekonstrukcijom mape interakcija na EE-ERC sučelju pomoću BioID testa, imunoprecipitacije, Western blot analize i subcelularnog frakcioniranja. MCMV učinak na kompleksnu mrežu regulatornih proteina i efektora na EE-ERC sučelju će predstavljati značajan znanstveni doprinos ovog projektnog prijedloga. On će razjasniti ne samo najranije stadije patogeneze beta-herpesvirusne infekcije, već i prostorno-vremenske odnose u neinficiranim stanicama, dva nedovoljno razjašnjena fundamentalna biološka procesa.]]></summary_hr><summary_en><![CDATA[The biogenesis of cVAC (cytoplasmic virion assembly compartment) is an outstanding and unresolved issue in the biology of herpesviruses. In this research proposal we will study the earliest stages of host-cell membranous-organelle reorganization which we considers as preAC (pre-assembly compartment). This project represents an extension of our previous work and focuses on cellular mechanisms exploited by murine cytomegalovirus (MCMV) at the interface between early endosomes and endosomal recycling compartment (EE-ERC), since the targeting the EE-ERC interface may be initiation step in the cVAC biogenesis. To achieve this, MCMV may target (1) host-cell effectors that regulates processes of sorting and retrieving at the EE-ERC interface, (2) Rab10 and its interacting partners, regulatory proteins that controls EE-ERC trafficking, and (3) ubiquitination processes that act as a regulatory rheostat mechanism in the endocytic recycling. These potential MCMV targets are aligned as three objectives of the research proposal. To address them, we will test almost 50 host-cell effectors and regulators of the EE-ERC interface and their role in the preAC development. Cells will be infected with wild type and various MCMV recombinants, and host-cell factors analyzed by knock-down (siRNA, inhibitors) and knock-out experiments (CRISPR-Cas9). The preAC development will be monitored by confocal microscopy and reconstruction of the roadmap at the EE-ERC interface by BioID assay, immunoprecipitation, Western blot analysis, and subcellular fractionation. The effect of MCMV on a complex network of host-cell regulatory proteins and effectors at the EE-ERC interface will be a significant research outcome of the project proposal. This outcome may resolve both, the earliest stages in the pathogenesis of beta-herpesvirus infection, and the spatial-temporal physiology of the EE-ERC interface in non-infected cells, the two insufficiently understood fundamental biological processes.]]></summary_en></project><project>
<id>13586</id><title_hr><![CDATA[Autonomni sustav bespilotnih letjelica za traženje i spašavanje na moru]]></title_hr><title_en><![CDATA[]]></title_en><user_id>26140</user_id><user_firstLast_name>Stefan Ivić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-1707</code><acronim><![CDATA[AOSeR]]></acronim><duration>13.12.2021 - 12.12.2025</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Temeljne tehničke znanosti, </scie_field_hr><scie_field_en>Basic engineering sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Tehnički fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Engineering]]></institution_en><team_members_id>865250</team_members_id><team_members_names><![CDATA[ Doktorand: Karlo Jakac Jakac ]]></team_members_names><keywords_hr><![CDATA[bespilotne letjelice, više-agentno pretraživanje, kontrola gibanja, detekcija meta, strujanje morske površine]]></keywords_hr><keywords_en><![CDATA[UAV, multi-agent search, motion control, target detection, sea surface flow]]></keywords_en><summary_hr><![CDATA[Korištenje bespilotnih letjelica (UAV) u misijama pretraživanja ima brojne prednosti, uključujući manevrabilnost, smanjenje ljudskog rizika i ekonomičnost. Primjena algoritama pretraživanja osigurava prostor za razvoj i korištenje najsuvremenijih metoda koje uvelike mogu povećati performanse pretraživanja. Pri traženju nestacionarnog cilja, poput osobe koja pluta u moru, razmatranje njegove dinamike kretanja presudno je za uspjeh pretraživanja. Predlažemo da se ispita primjenjivost nove metode pokrivanja područja i sustava detekcije i osjetila na problem pretraživanja u oceanskim okruženjima. Za metodu pokrivanja područja namjeravamo upotrijebiti HEDAC (pokrivanje područja pogonom toplinske jednadžbe) koja se pokazala kao jedan od najnaprednijih algoritama za heterogenu kontrolu više agenata u stacionarnim uvjetima. HEDAC bi trebao omogućiti pretraživanje nestacionarne distribucije meta s upotrebom više agenata. Planiramo koristiti više UAV-ova s heterogenom senzorskom opremom i parametrima leta. To će biti UAV-ovi s rotacijskim krilima opremljeni kamerama vizualnog i infracrvenog spektra. Vizualno otkrivanje i robusno praćenje ciljeva može se postići korištenjem nadziranih ili polu-nadziranih dubokih konvolucijskih i ponavljajućih neuronskih mreža. Predložena istraživanja uključuju dvije vrste eksperimenata. Prvi bi eksperiment bio osnovni scenarij pretraživanja sa stacionarnim ciljevima. U drugom pokusu, koji je izvedivo pretraživanje na moru, UAV će morati samostalno detektirati plutajuće ciljeve, prateći tako ažuriranu pokrivenost cilja u stvarnom vremenu. Brzina morske površine kontinuirano će se mjeriti pomoću raspršenih plutača s GPS-om, koje će se koristiti za hranjenje sustava predviđanja strujanja mora baziranog na strojnom učenju. Budući da se konvencionalno pretraživanje oslanja na pretpostavke stalne i ujednačene raspodjele ciljeva, predloženi postupak trebao bi predstavljati značajno poboljšanje metodologije pretraživanja.]]></summary_hr><summary_en><![CDATA[The utilization of Unmanned Aerial Vehicles (UAVs) in search missions has many advantages, including maneuverability, human risk reduction and cost effectiveness. The application of search  algorithms provides aspace to develop and use state-of-the-art methods which can greatly increase the performance of the search. When searching for a non-stationary target, such as a person floating in the sea, the consideration of its movement dynamics is critical to search success. We propose to test the applicability of a novel area coverage method and target detection and sensing system on the problem of searching in oceanic environments. For the area coverage method we intend to use HEDAC (Heat Equation Driven Area Coverage) method which has shown to be one of the most advanced algorithms for heterogeneous multi-agent control in steady conditions. HEDAC should allow the search for unsteady target distribution with the use of multiple agents. We plan to use multiple UAVs with heterogeneous sensing equipment and flight parameters. These will be rotary-wing UAVs equipped with visual and infrared spectrum cameras. Visual detection and robust tracking of targets can be accomplished by making use of supervised or semi-unsupervised deep convolutional and recurrent neural networks. The proposed research comprises two types of experiments. The first experiment would be a ground search scenario with stationary targets. In a second experiment, which is a feasible search at sea scenario, UAVs will need to detect floating targets autonomously, while following the real-time updated goal area coverage. Sea surface velocity will be continuously measured by use of scattered floating GPS-enabled buoys, which will be used for feeding a machine learning sea flow predictor system. Since conventional search relies on the presumptions of steady and uniform distribution of targets, the proposed procedure should represent a significant improvement in the search methodology.]]></summary_en></project><project>
<id>13588</id><title_hr><![CDATA[Biotehnološka primjena ugradnje heterolognih proteina u stanične stijenke kvasaca]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3258</user_id><user_firstLast_name>Renata Teparić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-9672</code><acronim><![CDATA[PRODIS]]></acronim><duration>24.11.2021 - 23.05.2026</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Biotehnologija, </scie_field_hr><scie_field_en>Biotechnology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Food Technology and Biotechnology]]></institution_en><team_members_id>865228</team_members_id><team_members_names><![CDATA[ Doktorand: Tea Martinić Cezar ]]></team_members_names><keywords_hr><![CDATA[molekularna biotehnologija, kvasac, S. cerevisiae, P. pastoris, stanična stijenka, izlaganje proteina, genetička imobilizacija, ksiloza reduktaza]]></keywords_hr><keywords_en><![CDATA[molecular biotechnology, yeast, S. cerevisiae, P. Pastoris,  cell wall, surface display, genetic immobilization, xylose reductase]]></keywords_en><summary_hr><![CDATA[Spoznaje vezane uz molekularne mehanizme biosinteze staničnih stijenki kvasaca omogućile su razumijevanje osnovnih bioloških principa koje stanice koriste za izgradnju vanjskog omotača s odgovarajućim biofizičkim i biokemijskim svojstvima i dizajniranje površine stanice u skladu s pojedinim biotehnološkim potrebama. Stanična stijenka sastoji se od unutrašnjeg kostura od ß-1,3- i ß-1,6-glukana i manoproteina čiji mananski lanci formiraju vanjski sloj stijenke. Dio proteina veže se na glukan nekovalentnim vezama, dok se drugi dio veže kovalentno, ili povezivanjem glikozilfosfatidilinozitolnog sidra i ß-1,6-glukana ili karakteristične Pir-sekvence s ß-1,3-glukanom. Dodavanje odgovarajućih signalnih sekvencija heterolognim proteinima eksprimiranima u kvascu omogućilo je njihovo izlaganje na površini stanice. Tako su stanice poslužile za biosintezu i imobilizaciju tih proteina, a postupak je omogućio kreiranje novih biološki aktivnih materijala. U svim do sada opisanim slučajevima količina aktivnosti eksprimirana na površini stanica bila je razmjerno mala pa je za primjenu ove tehnologije ključno povećati količinu heterolognih proteina izloženih na površini stanice. To će se u okviru ovog projekta pokušati modificiranjem različitih molekularnih procesa uključenih u izgradnju stijenke kao što su sekrecija, glikozilacija proteina, endocitoza, vezanje GPI sidra ili vezanje autohtonih proteina stijenke.U drugom dijelu, metoda izlaganja proteina primijenit će se na dva nova tehnološki važna proteina, metionil adenozin transferazu (MAT), ključnog enzima u proizvodnji S-adenozilmetionina i saharoza fosforilazu (SPaza) koja u reakciji sa saharozom katalizira sintezu glukozilglicerola. Oba proizvoda danas se dobivaju biotransformacijama pri čemu se supstrati moraju transportirati u stanicu kvasca što predstavlja limitirajući faktor u proizvodnji. Stoga bi relociranje reakcije izvan stanice moglo značajno olakšati proces biosinteze što će se istražiti u ovom projektu.]]></summary_hr><summary_en><![CDATA[Our knowledge on molecular mechanisms of yeast cell wall biosynthesis enabled comprehension of basic biological principles used to build the external envelope with adequate biophysical and biochemical properties and designing the cell surface according to specific biotechnological needs. Cell wall comprises inner moiety of ß-1,3- and ß-1,6-glucan, and mannoproteins whose mannan chains form the outer layer of the wall. A part of proteins are linked to glucan non-covalently, while some other are bound covalently, either through GPI-anchors and ß-1,6-glucan, or by linking a characteristic Pir-sequence to ß-1,3-glucan. Addition of corresponding signal sequences to heterologous proteins expressed in yeasts lead to their exposure at the cell surface. Thus, cells both synthesized and immobilized these proteins. As biologically active proteins can be exposed at the surface, the procedure enabled creation of new biologically active materials. So far the level of enzyme activity expressed at the cell surface was low and for the practical use of this methodology it would be important to increase the amount of heterologous protein in the wall. It will be attempted by modifying different molecular processes involved in wall formation like secretion, protein glycosylation,endocytosis,GPI-anchor addition, or binding of autochthonous cell wall proteins.In the second part, the surface display method would be applied to two new technologically important enzymes, methionine adenosine transferase (MAT), the key enzyme in the production of S-adenosyl methionine, and succrose phosphorylase that catalysis the formation of glucosyl glycerol in a reaction with succrose. Both products are presently produced by biotransformations in which substrates have to be transported into the yeast cells which presents the limiting production factor. Therefore, relocating the reaction to the external surface of the cell could facilitate the bioproduction which would be investigated in this project.]]></summary_en></project><project>
<id>13589</id><title_hr><![CDATA[Interakcija koroninih šupljina i sunčevih oluja]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6152</user_id><user_firstLast_name>Mateja Dumbović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-4229</code><acronim><![CDATA[ICOHOSS]]></acronim><duration>05.04.2023 - 04.12.2026</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Geodetski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Geodesy]]></institution_en><team_members_id>866192</team_members_id><team_members_names><![CDATA[ Doktorand: Akshay Kumar Remeshan ]]></team_members_names><keywords_hr><![CDATA[koronini izbačaji, koronine šupljine, korotirajuća područja interakcije, svemirska prognostika, fizika Sunca i Heliosfere]]></keywords_hr><keywords_en><![CDATA[coronal mass ejections, coronal holes, corotating interaction regions, space weather, solar and heliospheric physics]]></keywords_en><summary_hr><![CDATA[Koronini izbačaji (eng. Coronal mass ejections, CMEs), popularno zvane “Sunčevim olujama” najsilovitiji su eruptivni fenomeni u Sunčevom sustavu te su stoga u fokusu svemirske prognostike. Njihova interakcija s brzim tokovima koji potječu iz koronarnih rupa (eng. coronal hole, CH), regija niske gustoće plazme u sunčevoj koroni, može dovesti do još opasnijih poremećaja svemirskih vremenskih prilika. Cilj predloženog istraživanja je poboljšati razumijevanje interakcije CME-a i CH proučavanjem različitih tipova CME-CH interakcija, analizom udaljenosti interakcije i ako/kako CME-CH interakcija mijenja unutarnju magnetsku strukturu CME-a. Predlažemo da se to postigne opsežnom analizom CME-CH interakcija pomoću kombiniranog modeliranja i opservacijskog pristupa. Primijenit će se metode modeliranja „Sun-to-Earth“ u rasponu od CME 3D rekonstrukcije blizu Sunca, modeliranja propagacije i evolucije u heliosferi do in situ rekonstrukcije magnetske strukture. S druge strane, koristit će se opsežna opažanja različitih instrumenata na različitim  lokacijama u heliosferi, od EUV promatranja CME potpisa u niskoj sunčevoj koroni, opažanja koronagrafima, in situ i mjerenja na zemljinoj površini. Predložena istraživanja dovest će do dubljeg razumijevanja složenih sunčevih oluja, koje nisu rijetke pojave i mogu izazvati ozbiljne poremećaje svemirskih vremenskih prilika, posebice kod magnetski aktivnijih zvijezda od Sunca. Osim toga, poboljšat ćemo i dosadašnja znanja iz perspektive prognoziranja svemirskih vremenskih prilika, kako bi se ublažile štete vezane uz složene i, dakle, opasne poremećaje svemirskih vremenskih prilika.]]></summary_hr><summary_en><![CDATA[Coronal mass ejections (CMEs), popularly known as “Solar storms”, are the most violent eruptive phenomena in the solar system and most prominent drivers of the space weather. Their interaction with fast streams originating from coronal holes (CH), low-plasma density regions in the solar corona, can lead to even more hazardous space weather events. The proposed research aims to improve our understanding of the interaction of CMEs and CH and their (intensified) space weather effects by unravelling different types of CME-CH interactions, analysing the interaction distance and if/how the CME-CH interaction change the inner magnetic structure of the CME. We propose to achieve this through extensive analysis of CME-CH interactions using a combined modelling and observational approach. Modelling methods will be applied Sun-to-Earth ranging from CME 3D reconstruction close to the Sun, heliospheric propagation and evolution modelling to in situ reconstruction of the magnetic structure. On the other hand, extensive multi-spacecraft and multi-instrument observations will be used, ranging from EUV observation of the low coronal CME signatures, white-light observations, in situ and ground-based measurements. The proposed research will lead to a deeper understanding of complex solar storms, which are not are not uncommon phenomena and can cause severe space weather disturbances, even more so at magnetically more active stars. In addition, we will also improve our current knowledge from the perspective of forecasting space weather in order to mitigate damages related to complex and, hence, hazardous space weather events.]]></summary_en></project><project>
<id>13591</id><title_hr><![CDATA[Hibridno modeliranje pobuđenih stanja u novim molekularnim materijalima: od optičkih svojstava do dinamike ekscitona]]></title_hr><title_en><![CDATA[]]></title_en><user_id>24947</user_id><user_firstLast_name>Ivor Lončarić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-5899</code><acronim><![CDATA[HYMO4EXNOMOMA]]></acronim><duration>27.10.2021 - 26.10.2025</duration><status>Prekinut</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>865116</team_members_id><team_members_names><![CDATA[ Doktorand: Tea Ostojić ]]></team_members_names><keywords_hr><![CDATA[računalna znanost o materijalima, molekularni materijali, eksitoni, pobuđena stanja, optička svojstva, modeliranje, strojno]]></keywords_hr><keywords_en><![CDATA[computational material science, molecular materials, excitons, excited states, optical properties, modeling, machine learning]]></keywords_en><summary_hr><![CDATA[U projektu se pomoću teorijskog i računalnog modeliranja istražuju pobuđena stanja i optička svojstva molekularnih materijala uz pomoć novih hibridnih metodologija. Prvi korak je definiranje strukture molekularnog kristala ili agregata koji se istražuje. Struktura se dobiva ili direktno iz eksperimenta ili se pretpostavlja pomoću računalnih modela. Zatim, iz simulacija pobuđenih stanja i molekularne dinamike dobivaju se parametri hamiltonijana koji opisuju ekscitone. Također će se razviti sučelje za algoritme za strojno učenje, koje će omogućiti poboljšanje parametriranja modelnih hamiltonijana, omogućavajući tako potpuni uvid u fiziku ekscitona na automatizirani način. U model će biti ugrađene mikroskopske informacije koje će dati uvid u optička svojstva i svojstva ekscitonske dinamike, koja će se usporediti i potvrditi u odnosu na eksperimente. Istraživani sustavi uključivat će inovativne organske i bio-molekularne materijale, nudeći ovom projektu priliku za razumijevanje i kontrolu njihovih raznolikih i perspektivnih optičkih svojstava.]]></summary_hr><summary_en><![CDATA[The project investigates theoretical and computational modeling of excited states and optical properties in molecular materials through hybrid methodological approaches. The scheme require first to provide a structures of molecular crystals or aggergate, either obtained from experiment or guessed via computational tools. Exciton model hamiltonians will be fed by excited-state calculations and ab-initio molecular dynamics, to derive hamiltonian parameters. The interface of ad-hoc developed machine learning (ML) algorithms will be also developed, allowing ML to improve the parametrization of the model hamiltonian, hence providing a full insight into excitons physics in an automatized fashion. The model will embed microscopical information that will translate into optical and exciton dynamical properties, to be finally compared and validated against experiments. Systems investigated will include innovative organic and bio- molecular materials, offering this project the chance to understand and control their diverse and promising optical properties.]]></summary_en></project><project>
<id>13592</id><title_hr><![CDATA[Istraživanje i razvoj autonomnog robotskog vatrogasnog aparata za prevenciju, ranu detekciju i gašenje požara (Kod projekta: KK.01.2.1.02.0014)]]></title_hr><title_en><![CDATA[]]></title_en><user_id>25928</user_id><user_firstLast_name>Josip Balen</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-7509</code><acronim><![CDATA[]]></acronim><duration>03.11.2021 - 02.11.2025</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera Osijek, Fakultet elektrotehnike, računarstva i informacijskih tehnologija Osijek]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Electrical Engineering, Computer Science and Information Technology Osijek]]></institution_en><team_members_id>865189</team_members_id><team_members_names><![CDATA[ Doktorand: Matej Arlović ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>14587</id><title_hr><![CDATA[Robusno kodiranje strukturiranog svjetla za 3D oslikavanje u teškim uvjetima]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6641</user_id><user_firstLast_name>Tomislav Petković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-9474</code><acronim><![CDATA[3D-CODING]]></acronim><duration>21.07.2021 - 20.07.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>864843</team_members_id><team_members_names><![CDATA[ Doktorand: Domagoj Zoraja ]]></team_members_names><keywords_hr><![CDATA[strukturirano svjetlo, funkcije kodiranja, kalibracija projektora, podvodno 3D skeniranje, računalno oslikavanje]]></keywords_hr><keywords_en><![CDATA[structured light, coding functions, projector calibration, underwater 3D scanning, computational imaging]]></keywords_en><summary_hr><![CDATA[Površinsko 3D skeniranje korištenjem strukturiranog svjetla (SL) ima brojne primjene što između ostalog uključuje industrijsku metrologiju, skeniranje ljudskog tijela, dokumentiranje kulturne baštine i senziranje za robote. U skeniranju SL-om aktivni izvor svjetla osvjetljava neki objekt koristeći odabrani uzorak kojeg snima kamera. Dekodiranje snimljenog uzorka omogućuje rekonstrukciju površinskog profila kroz triangulaciju. Ključna komponenta uspješnog 3D skeniranja je odabrani uzorak SL-a i pripadna funkcija kodiranja. Većina postojećih skenera koji koriste SL, i komercijalnih i znanstvenih, je ograničena na 3D oslikavanje površine u kontroliranim uvjetima kao što je tamna soba gdje su interferencije i ostali neželjeni efekti zanemarivi. Otklanjanje takvih ograničenja i omogućavanje upotrebe 3D skeniranja izvan laboratorija zahtijeva dizajniranje novih uzorke SL-a i pripadne novih funkcija kodiranja. Taj istraživački cilj je sažeto opisan sljedećim prilično teškim istraživačkim pitanjem: „Koje su optimalne funkcije kodiranja?“. Cilj ovog projekta je ostvariti i teorijski i primijenjeni doprinos koji će nas približiti odgovoru na to pitanje. U okviru projekta će se istraživati robusne funkcije kodiranja za površinsko 3D oslikavanje u teškim uvjetima. Teški uvjeti koji će biti razmatrani uključuju globalnu interferenciju u obliku izravnog sunčevog svjetla i problem oslikavanja SL-om u raspršujućoj okolini što se najbolje istražuje na problemu podvodnog skeniranja u bistroj i mutnoj vodi. Očekivani teorijski doprinos je multidisciplinaran i upada presjek polja obrade signala, računalnog vida i optike a tiče se dizajna robusnih funkcija kodiranja za 3D oslikavanje. Očekivani primijenjeni doprinos je napravljen sustav za 3D skeniranje na otvorenom i pod vodom čija uporabnost je eksperimentalno potvrđena.]]></summary_hr><summary_en><![CDATA[Surface 3D scanning using structured light (SL) has numerous applications including among others industrial metrology, human body scanning, documenting cultural heritage and robot sensing. In SL scanning an active light source illuminates an object using a specific pattern which is observed by a camera. Decoding the observed pattern enables surface profile recovery via triangulation. The key to the successful 3D scanning is the selected SL pattern and the associated coding function. Most of the existing SL scanners, both commercial and scientific, are limited to 3D surface imaging in controlled environments such as dark rooms where interferences and other unwanted effects are negligible. To mitigate current limitations and to bring the 3D scanner outside of the lab novel SL patterns and associated novel coding functions must be designed. This research goal is summarized by the following quite difficult question: “What are the optimal coding functions?”. The aim of this project is to produce both theoretical and applied contribution which will bring us closer to answering this question. In this project robust coding functions for 3D surface imaging in difficult conditions will be investigated. The difficult conditions which will be considered include global interference in the form of direct sunlight and the problem of SL imaging in scattering media which is best investigated in an underwater scanning scenario including both clear and turbid water. The expected theoretical contribution is multi-scope as it falls at the intersection of signal processing, computer vision and optics and concerns the design of robust coding functions for 3D imaging. The expected applied contribution is a working system for 3D scanning in the open and underwater whose operation is experimentally verified.]]></summary_en></project><project>
<id>14588</id><title_hr><![CDATA[Ravnoteža sila i momenta sila u diobenom vretenu]]></title_hr><title_en><![CDATA[]]></title_en><user_id>11207</user_id><user_firstLast_name>Iva Tolić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-4097</code><acronim><![CDATA[SpindleForceBalance]]></acronim><duration>09.12.2021 - 08.12.2025</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>865242</team_members_id><team_members_names><![CDATA[ Doktorand: Ana Petelinec ]]></team_members_names><keywords_hr><![CDATA[sile i momenti sila, diobeno vreteno, mikrotubuli, model srednjeg polja, mikroskopija]]></keywords_hr><keywords_en><![CDATA[forces and torques, mitotic spindle, microtubules, mean-field model, microscopy]]></keywords_en><summary_hr><![CDATA[Diobeno vreteno je samoorganizirani mikro stroj sastavljen od mikrotubula i pripadajućih proteina, a dijeli genetski materijal između dvije stanice kćeri u nastajanju. Sile koje djeluju u diobenom vretenu tijekom mitoze ključne su za njegovo funkcioniranje u svakoj fazi. U metafazi, diobeno vreteno ima prepoznatljiv oblik s karakterističnim rasporedom mikrotubula. Mikrotubuli se protežu između suprotnih polova vretena, a međudjelu s kromosomima i međusobno. Sile koje djeluju na kinetohorne mikrotubule drže kromosome pod napetošću u metafaznoj ploči, što pridonosi utišavanju kontrolne točke udiobenom vretenu. Iako je postignut značajan napredak u razumijevanju mehanike vretena, pitanje ravnoteže sile u diobenom vretenu je još uvijek predmet znanstvene rasprave. Glavna ideja ovog projekta je istražiti ravnotežu sile cijelog vretena, na temelju našeg prethodnog rada na pojedinačnimsnopovima mikrotubula. Opisat ćemo ravnotežu sile vretena uvođenjem pristupa srednjeg polja gdje će se diskretni snopovi mikrotubula u određenom području, zajedno sa silama i momentima sila tih snopova, aproksimirati prosječnim snopom. Model će dati predviđanja za sile i momente sila u vretenu, te će stoga predvidjeti oblik cjelokupnog vretena uključujući oblike unutarnjeg i vanjskog snopa. Predviđeni oblici će se usporediti s oblicima promatranim u našim eksperimentima. Na temelju tih informacija ponudit ćemo mehaničko objašnjenje oblika unutarnjih i vanjskih snopova, uključujući velike razlike između njih. Ovaj pristup će pružiti sveobuhvatan uvid u sile i momente sila koji djeluju u cijelom vretenu, koji su ključni za pravilnu diobu stanica.]]></summary_hr><summary_en><![CDATA[The mitotic spindle is a self-organized micro-machine composed of microtubules and the associated proteins, which divides genetic material between the two nascent daughter cells. Forces exist in the spindle throughout mitosis and are crucial for spindle functioning in each phase. In metaphase, the mitoticspindle has a recognizable shape with a characteristic arrangement of microtubules. Microtubules extend from the opposite spindle poles and interact with the chromosomes and with each other. Forces exerted by kinetochore microtubules keep the chromosomes under tension at the metaphase plate,which contributes to silencing of the spindle assembly checkpoint. Though a significant progress in understanding the mechanics of the spindle is achieved, the question of force balance in the spindle is still under debate. The central idea of this project is to explore the force balance of the entire spindle, based on our previous work on individual microtubule bundles. We will describe the force balance of the spindle by introducing a mean-field approach where discrete microtubule bundles in a certain region, together with forces and torques exerted by these bundles, will be approximated by an averaged bundle.The model will provide predictions for forces and torques in the spindle, and consequently it will predict the shape of the entire spindle including the shapes of inner and outer bundles. The predicted shapes will be compared with shapes observed in our experiments. Based on such information, we will provide a mechanical explanation for shapes of inner and outer bundles, including major differences between them. This approach will provide comprehensive insight in forces and torques acting in the entire spindle, which are crucial for proper cell division.]]></summary_en></project><project>
<id>14589</id><title_hr><![CDATA[Razvoj sustava za ispitivanje višefaznih strujanja i izgaranja s ciljem povećanja istraživačkih aktivnosti znanstvenog i poslovnog sektora, KK.01.1.1.04.0070]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5045</user_id><user_firstLast_name>Jakov Baleta</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-7875</code><acronim><![CDATA[]]></acronim><duration>01.11.2021 - 01.11.2025</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, </scie_field_hr><scie_field_en>Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Metalurški fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Metallurgy]]></institution_en><team_members_id>865179</team_members_id><team_members_names><![CDATA[ Doktorand: Martin Trgovec-Greif ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>14590</id><title_hr><![CDATA[Longitudinalno istraživanje stresa adolescenata]]></title_hr><title_en><![CDATA[]]></title_en><user_id>2729</user_id><user_firstLast_name>Goran Milas</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-6877</code><acronim><![CDATA[]]></acronim><duration>01.12.2021 - 01.06.2026</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Psihologija, </scie_field_hr><scie_field_en>Psychology, </scie_field_en><institution_hr><![CDATA[Institut društvenih znanosti Ivo Pilar]]></institution_hr><institution_en><![CDATA[Institute of Social Sciences Ivo Pilar in Zagreb]]></institution_en><team_members_id>865230</team_members_id><team_members_names><![CDATA[ Doktorand: Filipa Ćavar ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>14591</id><title_hr><![CDATA[Testiranje 5C modela pozitivnog razvoja mladih: tradicionalno i digitalno mobilno mjerenje (P.R.O.T.E.C.T.)]]></title_hr><title_en><![CDATA[]]></title_en><user_id>13404</user_id><user_firstLast_name>Josipa Mihić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-1169</code><acronim><![CDATA[]]></acronim><duration>01.11.2021 - 31.12.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Edukacijsko-rehabilitacijske znanosti, </scie_field_hr><scie_field_en>Physical education and rehabilitation sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Edukacijsko-rehabilitacijski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Education and Rehabilitation Sciences]]></institution_en><team_members_id>25386</team_members_id><team_members_names><![CDATA[ Doktorand: Hana Gačal ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>14592</id><title_hr><![CDATA[Profesionalizam u zdravstvu: odlučivanje u praksi i znanosti]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4000</user_id><user_firstLast_name>Damir Sapunar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-7252</code><acronim><![CDATA[ProDeM]]></acronim><duration>21.07.2022 - 21.12.2025</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Javno zdravstvo i zdravstvena zaštita, </scie_field_hr><scie_field_en>Public health and health services, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Split School of Medicine]]></institution_en><team_members_id>865474</team_members_id><team_members_names><![CDATA[ Doktorand: Luka Ursić ]]></team_members_names><keywords_hr><![CDATA[istraživanje u zdravstvu, zdravstvena praksa, odlučivanje, medicina utemeljena na dokazima, istraživačka odgovornost, znanstvena evaluacija]]></keywords_hr><keywords_en><![CDATA[health research, health practice, decision making, evidence-based medicine, research integrity, research evaluation]]></keywords_en><summary_hr><![CDATA[Predloženi projekt nastavlja istraživanja profesionalizma u zdravstvu iz prethodnog HRZZ projekta. U ovom se projektu usredotočujemo na odlučivanje kao važan čimbenik u zdravstvenoj skrbi i znanosti. Prva istraživačka tema usmjerena je na to kako pacijenti, studenti i zdravstveni stručnjaci donose odluke u praksi, utemeljene na tekstualnim sažetcima sinteze dokaza u Cochraneovim sustavnim pregledima zdravstvenih intervencija. Temeljem nalaza iz tog dijela istraživanja, testirat ćemo intervencije za poboljšanje odlučivanja u praksi. Intervencije će uključivati smjernice za kliničku praksu i mrežni alat. Druga istraživačka tema usmjerena je na donošenje odluka u istraživanju u zdravstvu u širem kontekstu znanstvene evaluacije. Istražit ćemo čimbenike koji utječu na odlučivanje o znanstvenoj čestitosti, analizom organizacijske etičke klime na medicinskom fakultetu u usporedbi s drugim fakultetima i testiranjem intervencija za poticanje razumijevanja etičkih pitanja. Kvalitativno i kvantitativno ćemo istražiti proces donošenja odluka o kvaliteti znanstvenog istraživanja u zdravstvu proučavanjem postupka evaluacije znanstvenih projekata i članaka u časopisima. U tom dijelu projekta radit ćemo s podatcima koje smo dobili od znanstvenih izdavača i agencija za financiranje znanosti. Pristup svakom specifičnom cilju istraživanja bit će utemeljen na trenutnom znanju i identifikaciji relevantnih istraživačkih pitanja; na uporabi adekvatnih istraživačkih ustroja i inovativnih metodologija, uključujući strojno učenje i računalnu jezičnu analizu; na sintezi rezultata u eksplanatorne teorije i modele; i na razvoju oruđa i diseminaciju rezultata važnih za javnu politiku i pristup zdravstvenoj skrbi. Bolje razumijevanje donošenja odluka u zdravstvenoj praksi i znanosti donijet će nove spoznaje i oruđa za poboljšanje zdravstvene skrbi i donijeti važne ekonomske i javnozdravstvene koristi.]]></summary_hr><summary_en><![CDATA[The proposed project aims to continue the research on professionalism in health from the previous CSF project. In this proposal, we focus on decision making as an important aspect of health care and research. The first research theme addresses decision making in health care practice. We will investigate the determinants of decision making by patients, students and health professionals in relation to textual summaries of evidence synthesis in Cochrane systematic reviews of health interventions. Based on the findings from this research, we will test interventions to improve making decisions in health. The interventions will include health practice guidelines and a web-based tool. The second research theme addresses decision making in health research within the wider context of research evaluation. We will explore factors that contribute to decision making about integrity in research, by analysing the ethical climate at a medical school compared to other university schools and by testing interventions to increase awareness about ethics issues. We will also study the process of decisions about quality of health research by qualitative and quantitative analysis of the peer evaluation of research grant proposals and of journal articles. This part of research will use dataset that were made available to us by granting bodies and journals. Each specific objective of the proposed research will be based on current evidence and identified knowledge gaps; it will use appropriate research design and innovative methodological tools, including machine learning and deep language analysis; it will synthesise research results into explanatory theories and models; and it will develop tools and disseminate results and experience relevant for policy and public use. Better understanding of how decisions are made in health practice and research will provide evidence and new tools to inform improving health care and bring important economic and public health benefits.]]></summary_en></project><project>
<id>14595</id><title_hr><![CDATA[Međugeneracijski prijenos rizika za mentalno zdravlje adolescenata]]></title_hr><title_en><![CDATA[]]></title_en><user_id>13038</user_id><user_firstLast_name>Marina Ajduković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-8583</code><acronim><![CDATA[]]></acronim><duration>01.11.2021 - 26.04.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Socijalne djelatnosti, </scie_field_hr><scie_field_en>Social work, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Pravni fakultet u Zagrebu]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Law]]></institution_en><team_members_id>24348</team_members_id><team_members_names><![CDATA[ Doktorand: Petra Kožljan ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>14596</id><title_hr><![CDATA[Razvoj modela za procjenu ponašanja materijala temeljenih na strojnom učenju]]></title_hr><title_en><![CDATA[]]></title_en><user_id>12834</user_id><user_firstLast_name>Robert Basan</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-5586</code><acronim><![CDATA[MADEIRA]]></acronim><duration>01.12.2021 - 01.12.2025</duration><status>Prekinut</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, </scie_field_hr><scie_field_en>Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Tehnički fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Engineering]]></institution_en><team_members_id>865231</team_members_id><team_members_names><![CDATA[ Doktorand: Ela Marković ]]></team_members_names><keywords_hr><![CDATA[ponašanje materijala, zamor materijala, toplinska obrada, strojno učenje, modeliranje materijala]]></keywords_hr><keywords_en><![CDATA[material behavior, fatigue of materials, heat treatment, machine learning, materials modelling]]></keywords_en><summary_hr><![CDATA[Modeliranje ponašanja materijala ključan je dio suvremenog razvoja proizvoda te računalnih simulacija koje se provode u cilju čim boljeg iskorištenja materijala i smanjenja mase i troškova. Za uspješno modeliranje ponašanja materijala nužno je poznavanje njegovih značajki i parametara ponašanja. Njihovo eksperimentalno određivanje je najtočnije, ali je dugotrajno i skupo te se stoga nastoji izvoditi u najmanjoj mogućoj mjeri. Projektom MADEIRA cilja se na rješavanje nedostatka podataka o ponašanju materijala potrebnih za numeričke proračune i simulacije koji otežava šire prihvaćanje modeliranja materijala te uključivanje naprednih materijalnih modela u suvremeni proces razvoja proizvoda. Predloženo istraživanje usmjereno je razvoju modela za procjenu ponašanja i parametara materijala temeljenih na strojnom učenju kao rješenja za navedene probleme. Na osnovi prikupljenih rezultata istraživanja materijala i rezultata provedenih eksperimenata, sustavno će se istražiti, identificirati i mapirati kompleksni odnosi između svojstava/značajki materijala i njegovog mehaničkog ponašanja i pripadnih parametara na različitim razinama. Unaprijedit će se postojeći i razviti novi modeli procjene naprednih monotonih, cikličkih i zamornih parametara materijala te matematički modeli termalnih postupaka prerade metala i modeliranja njihovih mehaničkih svojstava nakon toplinske obrade. Istražit će se primjenjivost raznih metoda strojnog učenja te mogućnosti procjene parametara i naprednih konstitutivnih materijalnih modela koji se zbog kompleksnosti i velikog broja potrebnih parametara otežano i rijetko primjenjuju u praksi. Razvijene baze podataka i prediktivni modeli trebali bi doprinijeti široj primjeni modeliranja ponašanja materijala i računalnih simulacija, a uspostavljen metodološki okvir i principi primjene strojnog učenja mogli bi biti korisni i primjenjivi za razvoj prediktivnih modela i u drugim područjima primjene i istraživanja materijala.]]></summary_hr><summary_en><![CDATA[Materials modeling is a key part of modern product development and computer simulations which are performed in order to improve material utilisation and reduce weight and costs. The main prerequisite for successful materials modeling is knowledge of its behavior and properties. Their experimental determination is the most accurate, but it is long-lasting and expensive, and there is a trend to perform as few experiments as possible. The MADEIRA project addresses the lack of material data and behavior parameters needed for numerical simulations which is one of the major obstacles to wider use of advanced material models in the industry. Proposed research aims at the development of advanced machine learning-based models for estimation of material behavior and related parameters as a solution for mentioned problems. Based on results of materials research and data collected from published sources and results of own experiments, complex relationships between properties and behavior of the materials will be systematically analyzed, identified and mapped at different levels. Existing models for estimation of advanced monotonic, cyclic and fatigue parameters will be improved and new ones developed. Mathematical models of thermal processes of metals and prediction of their mechanical properties after heat treatment will be further improved. The applicability of different machine learning-based methods for estimation of parameters of advanced constitutive material models will be investigated which, due to the large number of required material parameters, are rarely applied in industrial practice. Developed database and predictive models should contribute to the wider application of material behavior modeling and computer simulations, and the established methodological framework and principles of machine learning may be useful and applicable for the development of predictive models in other fields of material research and application.]]></summary_en></project><project>
<id>14597</id><title_hr><![CDATA[Sustav za optimizaciju gubitaka u naprednim mrežama (DistributIoN Grid Optimization) - DINGO]]></title_hr><title_en><![CDATA[]]></title_en><user_id>7348</user_id><user_firstLast_name>Juraj Havelka</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-1661</code><acronim><![CDATA[]]></acronim><duration>25.07.2022 - 24.09.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>865514</team_members_id><team_members_names><![CDATA[ Doktorand: Terezija Matijašević ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>14598</id><title_hr><![CDATA[Elektromagnetske strukture za nadolazeće generacije  komunikacijskih sustava ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6686</user_id><user_firstLast_name>Zvonimir Šipuš</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-2445</code><acronim><![CDATA[ELESECOM]]></acronim><duration>01.10.2021 - 30.09.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>865118</team_members_id><team_members_names><![CDATA[ Doktorand: Dubravko Tomić ]]></team_members_names><keywords_hr><![CDATA[elektromagnetizam, metamaterijali, antene, bežični senzori, nefosterovske mreže]]></keywords_hr><keywords_en><![CDATA[electromagnetics, metamaterials, antennas, wireless sensor, non-Foster network]]></keywords_en><summary_hr><![CDATA[Jedan od glavnih zahtjeva i pokazatelja kvalitete naprednih bežičnih komunikacijskih sustava je mogućnost komuniciranja s velikim brojem korisnika i uređaja koristeći velike brzine prijenosa. Stoga je izgradnja odgovarajućih antena i pripadajućeg sklopovlja  za upravljanje  tokom elektromagnetske energije svakako veliki inženjerski izazov. Takvi antenski sustavi uključuju svojstva širokopojasnog rada, višestruku funkcionalnost, upravljanje različiitm snopovima i / ili višestruki višestruki izlazno-ulazni  način rada (MIMO), kontrolu polarizacije, prostorno i frekvencijsko filtriranje, aktivno i pasivno suzbijanje smetnji, čak uključujući radiofrekvencijsku obradu signala unutar sklopovlja antena. Trenutačno nije jasno koja bi tehnologija bila najbolji izbor za ispunjavanje svih ovih zahtjeva. Elektromagnetska skupina na Sveučilištu u Zagrebu iskoristit će svoje nedavne  rezultate istraživanja u metamaterijalima korištenjem tri komplementarna pristupa za uporabu u antenama i pripadajućim elektromagnetnim strukturama za buduće komunikacijske sustave. Prvi pristup temelji se na periodičnim strukturama za vođenje elektromagnetske energije u kombinaciji s lećama i metapovršinama. Ovaj pristup će dovesti do milimetarskih antenskih nizova s visokom učinkovitošću. Drugi pristup poboljšat će svojstva sustava ugradnjom naprednih aktivnih metamaterijalnih struktura kao što su radiofrekvencijski linearni i nelinearni podsustavi s negativnom impedancijom. Ovi aktivni podsustavi će omogućiti upravljanje glavnom zrakom i kontrolu polarizacije, zajedno s pretvorbom prema gore i prema dolje, te svojstvom samo-osciliranja. Treći se pristup bavi novom bežičnom senzorskom tehnologijom u milimetarskom režimu. U završnom dijelu projekta pokušat će se kombinirati znanje postignuto korištenjem sva tri pristupa integracijom u višenamjenski elektromagnetski sustav, prikladan za uporabu u novim sustavima komunikacija, senzora i pozicioniranja.]]></summary_hr><summary_en><![CDATA[One of the main requirements and quality indicators of the advanced wireless communications systems is the ability to communicate with a large number of users and devices with high-speed connections. Therefore,  construction of  the appropriate antennas and associated hardware for steering the flow of electromagnetic energy in emerging communication systems is certainly a big engineering challenge. The required properties of these antenna systems will include broad frequency-band operation, multi-functionality, beam steering and/or multiple-input multiple-output (MIMO) mode of operation, polarization control, spatial and frequency filtering, active and passive interference suppression including radiofrequency signal processing.  At the moment, it is not clear which technology would be the best choice for meeting these requirements. The electromagnetic group at University of Zagreb will leverage their recent advances in metamaterials by investigation of three complementary approaches for use in the antennas and associated electromagnetic structures for future emerging communication systems. The first approach will be based on the guiding periodic structures combined with lenses and metasurfaces. This approach will lead to millimeter antenna arrays with high efficiency. The second approach will enhance the system properties by incorporation of advanced active metamaterial-inspired structures such as negative-impedance linear and non-linear processing subsystems. These active subsystems will add tunability, steering and polarization control, together with up-conversion, down-conversion and self-oscillating properties.  The third approach will deal with novel wireless sensor technology in millimeter regime.  In the final part of the project, it will be attempted to combine knowledge achieved using all three approaches towards integration into a multi-functional electromagnetic system, convenient for use in emerging communications, sensing and positioning systems.]]></summary_en></project><project>
<id>14601</id><title_hr><![CDATA[Zeoliti s malim šupljinama modificirani bakrom pogodni za primjenu u zaštiti okoliša]]></title_hr><title_en><![CDATA[]]></title_en><user_id>620</user_id><user_firstLast_name>Ana Palčić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-7247</code><acronim><![CDATA[SMALLPORE]]></acronim><duration>08.10.2021 - 07.10.2025</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>865073</team_members_id><team_members_names><![CDATA[ Doktorand: Nikola Jakupec ]]></team_members_names><keywords_hr><![CDATA[zeoliti, male šupljine, bakar, dušikovi plinovi, uklanjanje]]></keywords_hr><keywords_en><![CDATA[zeolite, small pore, copper, nitrogen containing gases, elimination]]></keywords_en><summary_hr><![CDATA[Zeoliti su mikroporozni aluminosilikatni materijali definirane kristalne strukture unutar koje se nalazi sustav šupljina povezanih kanalima. Zbog specifične strukture i kemijskog sastava imaju veliku unutarnju površinu, adsorpcijski kapacitet te kapacitet ionska zamjene. Također su termički stabilni, a razina njihove hidrofobnosti se može mijenjati. Zeoliti s malim šupljinama imaju otvore šupljina omeđene osmeročlanim prstenovima. Pokazali su se izvrsnimkatalizatorima u procesu sinteze olefina iz metanola, ali i pri uklanjanju različitih štetnih plinova, posebice ispušnih plinova koji sadrže dušik. U sklopu predloženog projekta će se prirediti serija uzoraka zeolita s malim šupljinama (strukturni tipovi CHA, LTA, LEV) te provesti ionska zamjena bakrom kako bi se generirali metalni centri potrebni za katalitičke reakcije koje dovode do smanjenja emisije štetnih plinova. Kako bi se pripravili materijali s poboljšanimsvojstvima, sinteza materijala će biti potpomognuta mehanokemijskom predobradom polaznih spojeva. Mehanokemijski postupak će se također primijeniti prilikom ionske zamjene bakrom. Provest će se temeljita karakterizacija uzoraka, a oni koji će pokazati zadovoljavajuću (hidro)termičku stabilnost; količinu defekata unutar strukture; oblik i veličinu čestica; vrstu, jakost i raspodjelu kiselih mjesta te tip i raspodjelu bakrovih vrsti će biti ispitani kao katalizatori pri reakcijama uklanjanja plinovitih dušikovih spojeva. Posebna pozornost će se posvetiti ispitivanju djelovanja pripravljenih materijala prilikom selektivne katalitičke redukcije dušikovih oksida amonijakom te selektivne katalitičke oksidacije amonijaka.]]></summary_hr><summary_en><![CDATA[Zeolites are microporous crystalline alumosilicate materials with well-defined system of channels and cages. Due to their specific structure and chemical composition they have large internal surface area, adsorption capacity as w ell as ion-exchange capacity. They are thermally stable and the level of their hydrophobicity is tunable. Small-pore zeolites have pore openings comprising eight-membered rings. They present excellent catalyitic activity in thesynthesis of olefins from methanol (MTO), as w ell as in the elimination of various harmful gases, particularly nitrogen-containing exhaust gases. W ithin the proposed project, a series of small-pore zeolite materials (CHA-, LTA-, LEV-framew ork types) will be synthesized and subsequently ion-exchanged by copper which w ill generate the metal centers required for catalytic reactions leading to a reduction in the emission of harmful gases. In order to preparematerials with improved properties, the synthesis of the materials w ill be mechanochemically assisted by the pre-treatment of the starting compounds. The mechanochemical treatment is also going to be applied during the ion-exchange with copper. The obtained samples will be thoroughly characterized and those that will show adequate (hydro) thermal stability; quantity of the structural defects; particles’ shape and size; type, strength and distribution ofacid sites, as w ell as the type and distribution of the copper species are going to be tested as catalysts in the reactions of the gaseous nitrogen compounds removal. Particular attention will be devoted to the evaluation of catalytic activity of the prepared materials in the selective catalytic reduction of nitrogen oxides by ammonia and the selective catalytic oxidation of ammonia.]]></summary_en></project><project>
<id>14602</id><title_hr><![CDATA[NK stanice u patogenezi kongenitalne infekcije citomegalovirusom]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4834</user_id><user_firstLast_name>Ilija Brizić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-6327</code><acronim><![CDATA[NKconCMV]]></acronim><duration>01.10.2021 - 30.09.2025</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Medicine]]></institution_en><team_members_id>865130</team_members_id><team_members_names><![CDATA[ Doktorand: Jelena Materljan ]]></team_members_names><keywords_hr><![CDATA[citomegalovirus, kongenitalna infekcija, NK stanice, iscrpljenost NK stanica, Eomes]]></keywords_hr><keywords_en><![CDATA[cytomegalovirus, congenital infection, NK cells, NK cell exhaustion, Eomes]]></keywords_en><summary_hr><![CDATA[Kongenitalna infekcija humanim citomegalovirusom (HCMV) najčešći je virusni uzročnik razvojnih i funkcijskih poremećaja živčanog sustava, kao što su mentalna retardacija, mikrocefalija i senzori neuralnog oštećenja sluha. S obzirom da je HCMV specifičan za vrstu u istraživanjima kongenitalne infekcije se koristi model infekcije miševa s mišjim citomegalovirusom (MCMV). U mnogim razvojnim aspektima novookoćeni su miševi ekvivalentni ljudskom fetusu u drugom trimestru trudnoće, što je i vrijeme kada najčešće dolazi do infekcije HCMV-om u trudnoći. NK stanice su važne za kontrolu infekcije citomegalovirusom (CMV), a nedavno je pokazano da tijekom infekcije CMV-om NK stanice pokazuju i karakteristike stečene imunosti. Međutim, utjecaj kongenitalne CMV infekcije na imunološka svojstva NK stanica i dalje je uvelike nepoznat. Kako bi odredili utjecaj kongenitalne infekcije citomegalovirusom na NK stanice, inficirat ćemo novookoćene miševe MCMV-om i pratiti sazrijevanje i funkcionalnost NK stanica. Naši preliminarni rezultati ukazuju da infekcija MCMV-om snažno utječe na sazrijevanje NK stanica, te potiče iscrpljivanje NK stanica karakterizirano smanjenjem izražaja transkripcijskog faktora Eomesa. Cilj ovog projekta je karakterizirati funkcionalne, fenotipske i transkripcijske promjene NK stanica uzrokovane perinatalnom MCMV infekcijom. Nadalje, cilj je odrediti čimbenike i mehanizme koji potiču iscrpljivanje NK stanica, te odrediti mogu li se procesi iscrpljivanja NK stanica spriječiti ili ispraviti. Ujedno, ovim projektom će se odrediti uloga NK stanica u kontroli virusa, te nastanku patologije uzrokovane infekcijom novookoćenih miševa. Predloženo istraživanje će značajno pridonijeti razumijevanju patogeneze kongenitalne infekcije citomegalovirusom, ali i boljem razumijevanju biologije NK stanica, a napose u patološkim uvjetima. ]]></summary_hr><summary_en><![CDATA[Congenital human cytomegalovirus (HCMV) infection is the most common viral cause of long-term neurodevelopmental sequelae, including mental retardation, microcephaly and sensorineural hearing loss. As HCMV does not cross species barrier, we employ a mouse model in which newborn mice are infected with mouse cytomegalovirus (MCMV) to study congenital cytomegalovirus (CMV) infection. In many aspects newborn mice are developmentally equivalent to the human fetus during 2nd trimester of gestation, a time period when HCMV infection in humans is most frequently acquired during pregnancy. NK cells play an important role in control of CMV infection, and adaptive features of NK cells in response to CMV infection are recently being increasingly recognized. However, the extent to which congenital CMV infection affects and shapes NK-cell mediated immunity is largely unknown. To address this issue, we will use MCMV infected newborn mice and follow the impact of infection on the maturation and functional properties of NK cells. Our preliminary results indicate that MCMV infection strongly affects the maturation of NK cells and induces NK cell exhaustion characterized by downregulation of transcription factor Eomes. The goal of this project is to characterize functional, phenotypic and transcriptional changes in NK cells following perinatal MCMV infection. Furthermore, the goal is to characterize the factors and mechanisms that induce NK cell exhaustion and to determine if NK cell exhaustion can be prevented or reverted. In addition, in the proposed study we will determine the role of NK cells in MCMV control and virus induced pathology in newborn mice. The proposed research is an important step towards better understanding of pathogenesis of congenital CMV infection, but will as well contribute to better understanding of NK cell biology in general, and especially in pathological conditions.]]></summary_en></project><project>
<id>14605</id><title_hr><![CDATA[Kontrola kvalitete proteina putem selektivne razgradnje u stanicama u mirovanju]]></title_hr><title_en><![CDATA[]]></title_en><user_id>20884</user_id><user_firstLast_name>Mirta Boban</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-2505</code><acronim><![CDATA[Q-CTRL]]></acronim><duration>01.11.2021 - 01.05.2026</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>865158</team_members_id><team_members_names><![CDATA[ Doktorand: Mihaela Pravica ]]></team_members_names><keywords_hr><![CDATA[neurodegeneracija, starenje, proteinski agregati, misfolding, ubikvitin, proteasom, stanično mirovanje]]></keywords_hr><keywords_en><![CDATA[neurodegeneration, aging, protein aggregates, misfolding, ubiquitin, proteasome, quiescence]]></keywords_en><summary_hr><![CDATA[Održavanje proteoma jedan je od najvažnijih zadataka stanice. Nakupljanje proteinskih agregata povezano je s procesom starenja i neurodegeneracije, primjerice u Alzheimerovoj bolesti. Kako bismo rasvijetlili uzrok bolesti, važno je razumjeti na koji način se zdrava stanica nosi s problemom agregacije proteina. Kako bi spriječile nakupljanje oštećenih proteina, stanice su razvile sofisticirani sustav za kontrolu kvalitete proteina (KKP), koji uključuje selektivnu razgradnju terminalno oštećenih proteina pomoću ubikvitin-proteasoma. Molekulski putevi KKP evolucijski su konzervirani od kvasca do čovjeka. Mnoge stanice u ljudskom organizmu, poput neurona, ne proliferiraju. Za razliku od proliferirajućih stanica, koje se mogu riješiti oštećenja asimetričnom diobom, ne-proliferirajuće stanice ne posjeduju ovu mogućnost. U ovom projektu cilj nam je istražiti specifičnosti KKP u ne-proliferirajućim stanicama, te ispitati utjecaj starenja na ove molekulske puteve KKP.  Kako bismo rasvijetlili ova pitanja, koristit ćemo stanični model relevantan za proučavanje ne-proliferirajućih stanica te starenja, mirujuće stanice kvasca Saccharomyces cerevisiae. Zanimljivo je da su proteasomi u ovim stanicama re-organizirani u citoplazmatske granule, te trenutno nije jasno jesu li ovi proteasomi aktivni.  U predloženim projektu ispitat ćemo predstavljaju li oštećeni proteini u mirujućim stanicama supstrat za selektivnu razgradnju sustavomu ubikvitin-proteasoma, ili drugih molekulskih puteva. Nadalje, ispitat ćemo jesu li misfolded protein mofdificirani ubikvitinom, te ako da, koji molekulski putevi su uključeni. Također ćemo ispitati na koji način starenje utječe na ove procese. Vjerujemo kako će rasvjetljavanje puteva kontrole kvalitete proteina u mirujućim stanicama kvasca doprinijeti razumijevanju kontrole kvalitete proteina u ne-proliferirajućim ljudskim stanicama, kao što su neuroni, te razumijevanju kako ove stanice sprečavaju nakupljanje oštećenih proteina i nastanak agregata.]]></summary_hr><summary_en><![CDATA[Maintaining a functional proteome is one of the major tasks of the cell. Increased levels of protein aggregates are associated with aging and neurodegeneration, such as in Alzheimer’s and Parkinson’s disease. A key to understanding the cause of the disease is elucidating how a functional cell deals with the problem of protein misfolding and aggregation.To prevent accumulation of damaged proteins, cells have developed intricate network of protein quality control (PQC) pathways, including selective degradation of terminally damaged proteins by the ubiquitin-proteasome system (UPS). Notably, pathways of degradation-mediated PQC are highly conserved from yeast to man. Many cells in the human body, such as neurons, are non-dividing. In contrast to proliferating cells, which can clear the damage by asymmetric cell division, non-dividing cells lack this possibility. In this project, we wish to address the specificities of degradation-mediated PQC in non-dividing cells, and examine how these pathways are affected by aging. To this end, we chose a model that is relevant for non-dividing cells and suitable for studying aging, quiescent yeast Saccharomyces cerevisiae. Intriguingly, in quiescent cells, proteasomes re-localize from the nucleus into the cytoplasmic storage granules, and it is presently unclear whether those proteasomes are active. Specifically, we will test whether misfolded proteins in quiescent cells are selectively targeted for degradation by the UPS or other pathways, in addition to known pathway of bulk autophagy. Furthermore, we will examine whether misfolded proteins are modified by ubiquitin, and if yes, by which pathways. Finally, we will test how these processes are affected by chronological aging. We believe that elucidating the protein quality control in quiescent yeast cells will contribute to understanding how non-dividing mammalian cells, such as neurons, prevent accumulation of misfolded proteins, therefore preventing formation of aggregates.]]></summary_en></project><project>
<id>14606</id><title_hr><![CDATA[Modeliranje i praćenje iskustvene kvalitete imerzivnih višemedijskih usluga u 5G mrežama]]></title_hr><title_en><![CDATA[]]></title_en><user_id>2775</user_id><user_firstLast_name>Mirko Sužnjević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-4157</code><acronim><![CDATA[Q-MERSIVE]]></acronim><duration>27.12.2023 - 26.10.2026</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>867543</team_members_id><team_members_names><![CDATA[ Doktorand: Nikolina Roso ]]></team_members_names><keywords_hr><![CDATA[modeliranje i praćenje iskustvene kvalitete, virtualna i proširena stvarnost, mobilne videokomunikacijske usluge, 5G, strojno učenje]]></keywords_hr><keywords_en><![CDATA[modeling and monitoring QoE, virtual and augmented reality, mobile videocommunication services, 5G, machine learning]]></keywords_en><summary_hr><![CDATA[Ubrzan razvoj u području telekomunikacija i mreža, temeljen na migraciji prema arhitekturama pete generacije (5G), utire put novim mogućnostima pružanja usluga. Predviđa se ostvarivanje niza novih slučajeva uporabe višemedijskih usluga s visokim zahtjevima na kašnjenje, pouzdanost i širinu pojasa, koji će postati sastavni dio svakodnevnog života ljudi. Primjeri uključuju napredne imerzivne aplikacije poput virtualne i proširene stvarnosti (engl. Virtual/Augmented Reality, VR/AR), igranja te strujanja videa ultra-visoke razlučivosti i s 360 stupnjeva. Skup aplikacija koje koriste VR/AR tehnologije zasigurno će se proširiti, te će uz rano usvojene primjene kao što je igranje uključiti i niz aplikacija za poboljšavanje društvenih iskustava, primjene u zdravstvu i obrazovanju ili u profesionalnim i industrijskim slučajevima. Uzevši u obzir kompleksnost takvih usluga, dostupnost novih uređaja, te nove domene primjene, istraživačka zajednica je suočena s izazovima istraživanja novih metodologija, modela i metrika koje bi omogućile razumijevanje i mjerenje iskustva krajnjeg korisnika. Istraživanje iskustvene kvalitete (engl. Quality of Experience, QoE) je stoga tijekom proteklih godina postalo istaknuto pitanje kojim se bave mrežni operatori i davatelji usluga. Adresiranje navedenih istraživačkih izazova inherentno zahtjeva multidisciplinaran pristup. Projekt Q-MERSIVE stoga u istraživačkom timu kombinira komplementarne ekspertize iz područja inženjerstva i mreža, dizajna sučelja/sustava i psihologije kako bi se ostvarili sljedeći ciljevi: 1) razvoj novih modela iskustvene kvalitete za imerzivne umrežene AR/VR 5G aplikacije i mobilne višekorisničke videokomunikacijske usluge, te 2) razvoj novih rješenja za praćenje iskustvene kvalitete i različitih pokazatelja performansi iz perspektive mreže, koristeći kao temelj razvijene modele iskustvene kvalitete. Rješenja će se temeljiti na tehnikama strojnog učenja, ali i analitičkim pristupima, ovisno o primjenjivosti.]]></summary_hr><summary_en><![CDATA[Rapid developments in the telecommunications and networking communities, centered around the migration towards 5G architectures, are paving the way towards new service delivery opportunities. A wide range of advanced applications are expected to become an integral part of people’s everyday lives, with examples including immersive applications, such as virtual reality (VR), augmented reality (AR), gaming, and ultra-high-definition/360-degree video streaming, requiring unprecedented high access speeds, fast rendering, and in certain cases ultra-low latency. Applications leveraging VR/AR technologies will likely go beyond early adopters such as gaming, to enhancing social experiences, healthcare, education, or being used in professional and industrial use cases. Given the complexity of such services, the availability of new hardware on the market, and new application domains, the research community is faced with the challenges of exploring new methodologies, models, and metrics to measure the end user experience. Quality of Experience (QoE) research has thus received much attention over the past years and has become a prominent issue addressed by network, service, and content providers. Addressing these research challenges inherently calls for a multidisciplinary approach. The Q-MERSIVE project combines complementary expertise from engineering and networking, interface/system design, and psychology, to achieve the following overall goals: 1) to propose novel QoE models for immersive 5G-enabled networked AR/VR applications and mobile multi-party conversational video communication services, that map underlying system, context, and user factors to QoE as perceived at the user level, and 2) to propose novel solutions for in-network monitoring of QoE and various Key Performance Indicators, using as a basis developed QoE models. Solutions will rely on machine learning-based techniques, as well as analytical approaches as applicable.]]></summary_en></project><project>
<id>14607</id><title_hr><![CDATA[Procjena tolerantnosti hrvatske germplazme vinove loze na sušu - TOLVIN]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1507</user_id><user_firstLast_name>Goran Zdunić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-8479</code><acronim><![CDATA[]]></acronim><duration>01.09.2021 - 01.03.2026</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Institut za jadranske kulture i melioraciju krša]]></institution_hr><institution_en><![CDATA[Institute for Adriatic Crops and Karst Reclamation in Split]]></institution_en><team_members_id>865080</team_members_id><team_members_names><![CDATA[ Doktorand: Luka Marinov Marinov ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>14608</id><title_hr><![CDATA[Usporedba reparacijskog odgovora koštanog tkiva upotrebom dentina, ksenogenog biomaterijala i autologne kosti, IP-2020-02-7875]]></title_hr><title_en><![CDATA[]]></title_en><user_id>25715</user_id><user_firstLast_name>Olga Cvijanović Peloza</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-4767</code><acronim><![CDATA[]]></acronim><duration>10.10.2022 - 11.10.2026</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Medicine]]></institution_en><team_members_id>865765</team_members_id><team_members_names><![CDATA[ Doktorand: Barbara Franovic Franovic ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>14609</id><title_hr><![CDATA[Računalni modeli za predviđanje i analizu ličnosti na temelju teksta]]></title_hr><title_en><![CDATA[]]></title_en><user_id>23215</user_id><user_firstLast_name>Denis Bratko</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-6859</code><acronim><![CDATA[psy.txt]]></acronim><duration>01.11.2021 - 31.10.2025</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Psihologija, </scie_field_hr><scie_field_en>Psychology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>29531</team_members_id><team_members_names><![CDATA[ Doktorand: Iva Vukojević ]]></team_members_names><keywords_hr><![CDATA[Obrada prirodnog jezika, strojno učenje, psihologija ličnosti, analiza teksta, jezik na internetu]]></keywords_hr><keywords_en><![CDATA[Natural language processing, machine learning, personality psychology, text analysis, online talk]]></keywords_en><summary_hr><![CDATA[Ljudi se razlikuju u obrascima razmišljanja, osjećanja i ponašanja, što utječe na njihovu interakciju i prilagođavanje intrapsihičkom, fizičkom i društvenom okruženju. Pojedinačne i stabilne razlike proučava  područje psihologije ličnosti. Mnoge razlike u ličnosti očituju se u jeziku i u načinu na koji se jezik koristi u društvenim interakcijama. To jezične podatke čini vrijednim izvorom podataka za istraživanje ličnosti, pogotovo u današnje vrijeme društvenih medija i velikih podataka, gdje na društvenim platformama nastaju ogromne količine teksta. Velike količine teksta, međutim, iziskuju računalni pristup analizi podataka temeljenoj na metodama obrade prirodnog jezika (NLP) i strojnom učenju. Tema ovog projekta jesu računalni modeli za analizu i predviđanje ličnosti iz teksta. Premda NLP i psihologija ličnosti imaju velik sinergijski potencijal, ova dva polja imaju različite ciljeve i vrijednosti, stoga su do sada u velikoj mjeri odvojena jedna od drugog. Ovaj se jaz može pripisati nedostatku odgovarajućih skupova podataka, interpretabilnih NLP modela koji modeliraju jezične pojave na razini diskursa te interdisciplinarnih vještina među istraživačima. Cilj ovoga projekta jest smanjiti taj jaz i postaviti osnove za istinski interdisciplinarno istraživanje u analizi ličnosti na temelju teksta. Projekt okuplja interdisciplinarni tim računalnih znanstvenika i psihologa ličnosti, s ciljem (1) izgradnje novih skupova podataka internetskog teksta i interakcije pogodnih za razvoj NLP modela i analizu ličnosti na temelju teksta, (2) razvijanja NLP modela za predviđanje i analizu ličnosti koji su inovativni, kreativni i učinkoviti, dok istovremeno osiguravaju valjanost i interpretabilnost te (3) provođenja niza konfirmatornih i eksploratornih studija analize podataka za otkrivanje povezanosti osobina ličnosti i jezičnih varijabli razgovora na internetu.]]></summary_hr><summary_en><![CDATA[People differ in patterns of thinking, feeling, and behaving, which influences how they interact and adapt to the intrapsychic, physical, and social environments. The individual and stable differences are studied by the field of personality psychology. Many differences in personality get manifested in language and in the way language is used in social interactions. This makes language data a valuable source of data for personality research, especially in today’s era of social media and big data, with vast amounts of text generated on social media platforms. The large quantities of text, however, mandate a computational approach to data analysis, using methods from natural language processing (NLP) and machine learning. The topic of this project are computational models for personality analysis and prediction from text. Although NLP and personality psychology have a high potential for synergy, the two fields have different goals and values and thus far remain largely disconnected from each other. The gap can be attributed to the lack of adequate datasets, lack of interpretable NLP models that target discourse-level linguistic phenomena, and lack of interdisciplinary skill sets among the researchers. With this project, we aim to narrow this gap and set the ground for truly interdisciplinary research on text-based personality analysis. The project brings together an interdisciplinary team of computer scientists and personality psychologists, with the objectives to (1) compile novel datasets of online text and interaction suitable for the development of NLP models and text-based personality research, (2) develop NLP models for text-based personality prediction and analysis that are innovative, creative, and effective, but at the same warrant validity and interpretability, and (3) run a number of confirmatory and exploratory data analysis studies to investigate the links between personality traits and linguistic variables of online talk and interaction.]]></summary_en></project><project>
<id>14611</id><title_hr><![CDATA[BioProspecting Jadranskog mora]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5798</user_id><user_firstLast_name>Ivančica Strunjak-Perović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-4850</code><acronim><![CDATA[]]></acronim><duration>02.11.2021 - 01.11.2025</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Biotehnologija, </scie_field_hr><scie_field_en>Biotechnology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>865109</team_members_id><team_members_names><![CDATA[ Doktorand: Tamara Vujović ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>14612</id><title_hr><![CDATA[&#39;Bioraznolikost i molekularno oplemenjivanje bilja&#39; u sklopu Znanstvenog centra izvrsnosti za bioraznolikost i molekularno oplemenjivanje bilja]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1294</user_id><user_firstLast_name>Klaudija Carović-Stanko</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-4342</code><acronim><![CDATA[]]></acronim><duration>01.10.2021 - 30.09.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Agronomski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Agriculture]]></institution_en><team_members_id>865110</team_members_id><team_members_names><![CDATA[ Doktorand: Tomislav Javornik ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>14613</id><title_hr><![CDATA[Potencijal arbuskularne mikorize da mijenja obranu vinove loze od virusa]]></title_hr><title_en><![CDATA[]]></title_en><user_id>2826</user_id><user_firstLast_name>Tomislav Radić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-2381</code><acronim><![CDATA[Myco Grape]]></acronim><duration>23.08.2021 - 22.08.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Institut za jadranske kulture i melioraciju krša]]></institution_hr><institution_en><![CDATA[Institute for Adriatic Crops and Karst Reclamation in Split]]></institution_en><team_members_id>865019</team_members_id><team_members_names><![CDATA[ Doktorand: Emanuel Gaši ]]></team_members_names><keywords_hr><![CDATA[arbuskularna mikoriza, vinova loza, virusi, interakcije, fiziološki biljni odgovor]]></keywords_hr><keywords_en><![CDATA[arbuscular mycorrhiza, grapevine, viruses, interactions, physiological plant response]]></keywords_en><summary_hr><![CDATA[Za arbuskularne mikorizne gljive (AMF) je dokazano da imaju potencijal smanjiti biotički stres kod biljaka i aktivirati mikorizom-induciranu otpornost. Međutim, postoje značajna nerazjašnjena pitanja o učinkovitosti AMF zaštite protiv biljnih virusa, a na vinovoj lozi takva istraživanja nisu rađena. U ovom projektu ćemo se baviti funkcionalnom interakcijom između vinove loze, AMF i virusa, imajući na umu sljedeće: globalnu važnost vinogradarstva, visok afinitet vinove loze za arbuskularnu mikoriznu simbiozu, potencijal AMF da ublaži biotički stres i nedostatak istraživanja o interakcijama biljaka, AMF i virusa na drvenastim poljoprivrednim kulturama. Kako bismo razjasnili postojeće nejasnoće o funkcionalnoj interakciji između vinove loze, AMF i virusa te procijenili potencijal AMF da mijenja virusnu infekciju vinove loze, postavit ćemo dva staklenička eksperimenta i jedan podeksperiment. Ciljevi projekta su: 1. odrediti kako pred- i postinokulacija s AMF utječe na fiziološke i molekularne odgovore vinove loze na virusnu infekciju, 2. kvantificirati vremensku i prostornu dinamiku virusne infekcije nakon cijepljenja, u ovisnosti o mikoriznom statusu lozne podloge, 3. istražiti može li zajednička mikorizna mreža između bezvirusne i virusom inficirane vinove loze biti signalni put upozorenja na viruse, 4. osnažiti znanstveni kapacitet Instituta za jadranske kulture uvođenjem funkcionalne genomike u njegova istraživanja interakcija između biljaka i mikroorganizama. Okrupnjivanje istraživanja ćemo postići uspostavom suradnje između četiri istraživačke institucije iz Hrvatske, Slovenije i Italije. U svjetlu održive poljoprivrede i nužnosti razvitka novih alata, od interesa je procijeniti korist upotrebe AMF u integriranom upravljanju zaštitom vinove loze od  virusa.]]></summary_hr><summary_en><![CDATA[Arbuscular mycorrhizal fungi (AMF) are proven to have potential for alleviation of biotic stress in plants and activation of mycorrhiza-induced resistance. However, there are significant gaps in the knowledge on bioprotection efficiency of AMF against the plant viruses and no investigations were conducted on the grapevine.  In this project we will address the functional interplay among the grapevine-AMF-viruses, having in mind the following: global importance of viticulture, grapevine high affinity to the arbuscular mycorrhizal symbiosis, AMF potential to alleviate biotic stress and lack of studies on plant-AMF-virus interactions at any woody crop. In order to elucidate the gaps in the knowledge on the functional interactions between grapevine, viruses and AMF and to estimate AMF potential to modify grapevine virus infection, we will set up two greenhouse experiments and one sub-experiment. The project objectives are: 1. to determine how pre- and post-inoculation with AMF affects grapevine physiological and molecular responses to virus infection; 2. to quantify temporal and spatial dynamics of virus infection after the grafting, depending on the rootstock mycorrhizal status; 3. to explore whether common mycorrhizal network between virus free and virus infected grapevine can be a pathway for virus warning signalling; 4. to strengthen scientific capacity of the Institute for Adriatic Crops by introducing functional genomics into its research of plant-microorganisms interactions. We will achieve consolidation of complementary research and equipment through established connections between four research institutions from Croatia, Slovenia and Italy. In view of sustainable agriculture and the necessity of new tools development, the proposed topic is of importance for evaluating the benefit of AMF application in an integrated viral management in viticulture.]]></summary_en></project><project>
<id>14615</id><title_hr><![CDATA[DATACROSS - Napredne metode i tehnologije u znanosti o podatcima i kooperativnim sustavima]]></title_hr><title_en><![CDATA[]]></title_en><user_id>18912</user_id><user_firstLast_name>Vedran Bilas</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-4461</code><acronim><![CDATA[]]></acronim><duration>21.07.2021 - 20.07.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>865003</team_members_id><team_members_names><![CDATA[ Doktorand: Marko Šimić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>14616</id><title_hr><![CDATA[Kopno ili more: ekološki i genetički aspekti izbora staništa crvenokljune čigre]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6172</user_id><user_firstLast_name>Ana Galov</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-3727</code><acronim><![CDATA[KiM: ČIGRE]]></acronim><duration>23.11.2021 - 22.11.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>865212</team_members_id><team_members_names><![CDATA[ Doktorand: Veronika Lončar ]]></team_members_names><keywords_hr><![CDATA[morske ptice, izbor staništa, genska varijabilnost, MHC ptica, antropogeni utjecaj]]></keywords_hr><keywords_en><![CDATA[seabirds, habitat choice, genetic variability, avian MHC, anthropogenic impact]]></keywords_en><summary_hr><![CDATA[Crvenokljuna čigra Sterna hirundo je kolonijalna vrsta ptice koja se većinom gnijezdi na niskim morskim obalama, ali nastanjuje i slatkovodna kontinentalna staništa. Selica je te zime provodi duž morskih obala južne polutke. Morska staništa čigrama pružaju stabilno mjesto za gniježđenje s većim područjem hranjenja, no na moru su prisiljene trošiti energiju na izlučivanje soli, a slanoća vode ima i imunosupresivno djelovanje. Slatkovodna staništa, iako površinom manja, imaju i postojaniju dostupnost plijena, pa su pogodnija za gniježđenje. No, većina kontinentalnih kolonija zbog antropogenih pritisaka danas ovisi o umjetnim otocima i platformama, koje je neprestano potrebno održavati.Cilj ovog projekta je utvrditi razlike u uspješnosti gniježđenja, genetičkoj raznolikosti i fitnesu, kvaliteti područja gniježđenja za hranjenje odraslih te utjecaja negnijezdećeg razdoblja između morskih i kontinentalnih kolonija crvenokljune čigre.Projekt će trajati 48 mjeseci i obuhvatiti četiri gnijezdeće sezone. Terenski će se rad odvijati na kolonijama duž rijeke Save u Zagrebačkoj županiji i na sjevernom Jadranu. Kretanje prilikom hranjenja istraživat ćemo pomoću GPS-UHF odašiljača, selidbu pomoću geolokatora, a uspješnost gniježđenja praćenjem veličine pologa i produktivnosti kolonije. Neutralnu genetičku raznolikost i strukturu populacija istražit ćemo pomoću kontrolne regije mtDNA  i mikrosatelitnih lokusa, dok ćemo adaptivnu genetičku varijaciju istražiti karakterizacijom i genotipizacijom MHC lokusa pomoću NGS amplikon sekvenciranja.Otkrivanje odnosa između staništa i uspješnosti gniježđenja, fitnesa i genetičke raznolikosti crvenokljunih čigri omogućit će procjenu njihove sposobnosti prilagođavanja antropogenim promjenama u staništu. Projekt će rezultirati s četiri znanstvena rada, i 8 prezentacija na četiri međunarodne znanstvene konferencije. Dva mlada istraživača razvit će znanstvene karijere kroz ovaj projekt.]]></summary_hr><summary_en><![CDATA[The Common Tern Sterna hirundo is a colonial bird species which mostly breeds on low-lying marine coasts, but it also inhabits freshwater inland habitats. It is migratory, wintering along sea coasts of the Southern Hemisphere. Marine habitats offer terns a stable breeding place with a larger feeding area, but on the sea they are forced to invest energy into excreting salt, and salinity itself has immunosuppressive effects. Freshwater habitats, although smaller in area, also have more consistent prey availability, so they are preferable for breeding. However, because of anthropogenic habitat pressure, most inland colonies now depend on artificial islands and rafts, which require continuous management.The goal of this project is to determine differences between marine and inland Common Tern colonies in breeding performance, genetic variability and fitness, quality of breeding area for adult foraging and carry-over effects of the non-breeding period. The project will last 48 months and encompass four breeding seasons. Field work will be conducted on colonies along the river Sava in Zagreb County and in the northern Adriatic. Foraging movements will be studied with GPS-UHF technology, migration by geolocators and breeding performance through clutch size and colony productivity. Neutral genetic diversity and population structure will be studied through mtDNA control region and microsatellite loci, and adaptive genetic variation through characterization and genotyping of MHC loci by NGS amplicon sequencing.Discovering the relationship between habitat and Common Tern breeding performance, fitness and genetic diversity will enable us to assess their ability to adapt to anthropogenic changes in their habitat. Project will result in four scientific articles and eight presentations at  four international scientific conferences. Project will also enable developing scientific careers for two young researchers. ]]></summary_en></project><project>
<id>14617</id><title_hr><![CDATA[Višerazinske konfiguracije organizacijskog dizajna: Razumijevanje dualnosti između heterogenosti i homogenosti]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5575</user_id><user_firstLast_name>Tomislav Hernaus</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-6601</code><acronim><![CDATA[MULTIORGDUAL]]></acronim><duration>01.02.2023 - 30.09.2026</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, </scie_field_hr><scie_field_en>Economy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Ekonomski fakultet u Zagrebu]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Economics and Business]]></institution_en><team_members_id>866595</team_members_id><team_members_names><![CDATA[ Doktorand: SARA MELKIĆ Melkić ]]></team_members_names><keywords_hr><![CDATA[organizacijski dizajn, organizacijske konfiguracije, kvalitativna komparativna analiza, dualnost heterogenosti i homogenosti, višerazinski pristup]]></keywords_hr><keywords_en><![CDATA[organization design, organizational configurations, qualitative comparative analysis, heterogeneity-homogeneity duality, multilevel approach]]></keywords_en><summary_hr><![CDATA[Dosadašnja istraživanja uglavnom slijede nerealne pretpostavke o homogenizaciji organizacijskih karakteristika. Međutim, upravo povezivanje i promatranje različitih organizacijskih praksi može dodati vrijednost. Slijedom toga, glavna svrha ovog istraživanja jest utvrditi i objasniti kako i zašto dolazi do razlika u uspješnosti uslijed odluka o organizacijskom dizajnu napravljenih na različitim razinama analize (pojedinac/posao, tim/jedinica i organizacija/sustav). Namjeravamo prepoznati višerazinske obrasce dizajniranja organizacija koji proizlaze iz različitih organizacijskih dualnosti (strateška, strukturalna i heterogenost upravljanja ljudima). Polazeći od teorije složenosti i primjenom konfiguracijskog pristupa bit će istraženi složeni međuodnosi struktura i praksi s gledišta jednakokonačnosti. Predloženi dizajn istraživanja obuhvaća provođenje tri studije i podrazumijeva korištenje mješovite metodologije. Prva studija predstavlja anketno istraživanje prakse dizajna organizacije i organizacijskih jedinica na uzorku hrvatskih, slovenskih i srbijanskih organizacija s ciljem utvrđivanja postojećih internih sposobnosti organizacijskog dizajna, kao i obrazaca organiziranja koji pozitivno ili negativno utječu na poslovni rezultat. Druga studija obuhvatit će akcijsko istraživanje u tri partnerske organizacije pri čemu će naglasak biti na utvrđivanju kako povezanost dizajna organizacijskih jedinica i dizajna posla utječe na radnu uspješnost zaposlenika. Konačno, treća studija omogućit će kreiranje modela zrelosti organizacijskog dizajna kroz primjenu Delfi tehnike na uzorku stručnjaka za organizacijski dizajn. Planirano istraživanje nastojat će potaknuti širenje znanja o dizajniranju učinkovitih organizacija ali i istaknuti koji obrasci ponašanja vode ka neuspjehu. ]]></summary_hr><summary_en><![CDATA[The existing research mainly followed unrealistic homogenizing assumptions of organizational attributes, not realizing that the association of heterogeneous organizational practices may add value. Therefore, the main purpose of our research is to determine and explain how and why performance differences emerge from design choices made at different levels of analysis (individual/job, team/unit and organization/system). We intend to search for multi-level organization designing patterns emerging from different organizational dualities (strategic, structural and HRM heterogeneity). Starting from the theory of complexity and using the configurational approach we will study the complex interplay of structures and practices from an equifinal point of view.The proposed research design includes three studies and applies a mixed research methodology. The first study represents a field survey research of organizational and business unit design on the sample of Croatian, Slovenian and Serbian companies. The aim is to identify the current level of internal organizational design capabilities, as well as to recognize organizational configurations which have either positive or negative effect on business unit performance. The second study is an action research within three partner organizations through which we plan to address how the relationship between business unit design and job design influences employee work performance. Finally, the third study will result in the organizational design maturity model development. A Delphi method will be used to target the sample of organizational design experts. The planned research is expected to enhance knowledge dissemination about designing effective organizations, as well as emphasize organizational configurations that are likely to result in failure.]]></summary_en></project><project>
<id>14618</id><title_hr><![CDATA[Efekt kvantnog tuneliranja: dinamika molekula s kvantnim jezgrama]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3692</user_id><user_firstLast_name>Marko Tomislav Cvitaš</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-2424</code><acronim><![CDATA[QuanTunMol]]></acronim><duration>07.02.2022 - 06.02.2026</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>865264</team_members_id><team_members_names><![CDATA[ Doktorand: Nina Tokić ]]></team_members_names><keywords_hr><![CDATA[instantoni, tuneliranjem uzrokovano cijepanje, metoda inegrala po stazama, kvantna molekulska dinamika, brzina tuneliranja]]></keywords_hr><keywords_en><![CDATA[instantons, tunnelling splitting, path-integral methods, quantum molecular dynamics, tunnelling rate]]></keywords_en><summary_hr><![CDATA[Kvantno tuneliranje igra važnu ulogu u molekulskoj dinamici i spektroskopiji, time što može znatno utjecati na reaktivnost i pregradnju molekula na načine koji bi inače bili zabranjeni. Instanton metoda pruža način da se aproksimira i vizualizira dinamika tuneliranja pomoću optimalnog puta tuneliranja duž kojeg se kvantni proces dominantno odvija. Oslanja se na optimizaciju putanje i time omogućava primjenu na mnogo većim molekulskim sustavima u punoj dimenzionalnosti nego što je to dostupno preciznijim metodama. Cilj ovog projekta je proširiti domenu primjenjivosti instanton metode i povećati njenu efikasnost kako bi se njome mogao proučavati širi spektar sustava. Naš je cilj da razvijemo novu instanton teoriju za računanje cijepanja vibracijski pobuđenih stanja uslijed tuneliranja kao i za račun rotacijskih energija. Te teorije namjeravamo primijeniti na spektre grozdova vode koji su nedavno mjereni, što će testirati potencijale vode na geometrijama koje su daleko od ravnotežnih i pružati uvid u dinamiku vodikovih veza, kako se one cijepaju, stvaraju i pregrađuju. U daljnjoj primjeni predviđamo proučavanje efekta supstitucije na vodikovu vezu kod nekih dimera supstituiranih karboksilnih kiselina kroz cijepanje uslijed tuneliranja. Također, cilj nam je razviti metode za efikasan pronalazak optimalnih puteva tuneliranja u računima brzine reakcije. Te metode primijenit ćemo na proučavanje fotoinducirane neadijabatske dinamike u elektronski pobuđenim stanjima, npr. indola ili fenola, kako bi interpretirali vremenski ovisne fotoelektronske spektre koristeći kombinaciju dinamike skokova među stanjima (FSSH) iznad barijere za disocijaciju vodika, te koristeći instantone za određivanje brzine tuneliranja ispod barijere za disocijaciju. Konačno, primijenit ćemo naše metode za izračun brzine tuneliranja za odabrane reakcije slobodnih radikala u vodenim otopinama kako bi odredili njihove mehanizme i kinetički izotopni efekt.]]></summary_hr><summary_en><![CDATA[Quantum tunnelling plays an important role in dynamics and spectroscopy of molecules. It can significantly affect reactivity and allow molecular rearrangements which would otherwise be forbidden. Instanton method provides a way to approximate and visualise tunnelling dynamics using an optimal tunnelling path along which the quantum process predominantly take place.  It relies on the optimization of the path, thus it enables us to treat much larger molecular systems in full dimensionality or rely on more accurate on-the-fly electronic potentials than the more accurate methods. The aim of this project is to extend the domain of applicability of the instanton method and to increase its efficiency in order to study systems that would otherwise be inaccessible. Specifically, we aim to develop a new instanton theory to calculate tunnelling splittings in vibrationally excited states and rotational energies. We will apply those theories to study tunnelling spectra in water clusters that have recently been measured, which will provide tests of water potentials at far-from-equilibrium geometries and insights into dynamics of hydrogen bonds, how they break, form and rearrange. Further applications envisage the study of the substituent effect on hydrogen bonds in some substituted carboxylic acid dimers through the associated tunnelling splittings. We also aim to develop methods for efficiently locating optimal tunnelling paths for rate calculations in nonadiabatic systems. These will be applied to study photo-excited nonadiabatic dynamics of indole or phenol and interpret time-resolved photoelectron spectra using a combination of surface-hopping dynamics above the H atom detachment barrier and instantons for the dissociation rates below the barrier. Finally, we will apply our methods to calculate tunnelling rates for selected free radical reactions which take place in aqueous solutions to determine mechanisms and estimate kinetic isotope effect.]]></summary_en></project><project>
<id>14620</id><title_hr><![CDATA[Umjetnost i država u Hrvatskoj od prosvjetiteljstva do danas]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3499</user_id><user_firstLast_name>Dragan Damjanović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-9354</code><acronim><![CDATA[ASCEP]]></acronim><duration>05.11.2021 - 05.11.2025</duration><status>Prekinut</status><financ_value></financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Povijest umjetnosti, </scie_field_hr><scie_field_en>Art history, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>865209</team_members_id><team_members_names><![CDATA[ Doktorand: Sanja Delić Delić ]]></team_members_names><keywords_hr><![CDATA[umjetnost, država, baština, politika, obrazovanje, muzeji, povijest umjetnosti, moderno i suvremeno doba]]></keywords_hr><keywords_en><![CDATA[state, art, heritage, politics, education, museums, history of art, late modern and contemporary period]]></keywords_en><summary_hr><![CDATA[Cilj je projekta Umjetnost i država u Hrvatskoj od prosvjetiteljstva do danas istražiti utjecaje koje su državne strukture vlasti imale na umjetničku produkciju te na interpretaciju umjetničkih djela i baštine.Budući da je hrvatski politički i kulturni prostor u promatranom razdoblju od kraja 18. stoljeća do osamostaljenja Hrvatske 1991., bio u sastavu raznih država (Habsburške, odnosno Austro-Ugarske Monarhije, prve i druge Jugoslavije, Kraljevine Italije, Nezavisne Države Hrvatske) istraživači na projektu pokušat će pokazati kako, koliko (i da li je) promjena državnih okvira utjecala na odnose prema umjetničkoj produkciji te kulturnoj i obrazovnoj politici uopće u polju vizualnih umjetnosti.Zbivanja u hrvatskoj umjetnosti nastojat će se kontekstualizirati sa situacijom u susjednim zemljama, odnosno s područjima kojima je Hrvatska politički pripadala te stoga uključuje brojna terenska, arhivska, muzejska i bibliotečna istraživanja. Istraživački ciljevi unutar projekta mogu se podijeliti u dvije osnovne skupine – istraživanje utjecaja države na sva polja likovnog stvaralaštva putem narudžbi, subvencija i kontrole nad umjetničkom produkcijom, te istraživanje utjecaja države na procese stvaranja i očuvanja umjetničke baštine kao i na formalno i neformalno obrazovanje u području likovnih umjetnosti.Uz voditelja u projekt je uključeno 14 istraživača, od kojih je 8 u statusu doktoranda ili postdoktoranda kojima je ovaj projekt od osobite važnosti za daljnju izgradnju znanstvenih karijera. Uključivanjem istraživača iz baštinskih institucija (muzeja, konzervatorskih odjela) nastojat će se produbiti međuinstitucionalna suradnja i omogućiti višedimenzionalno sagledavanje složenih odnosa države prema umjetnosti.Rezultate projekta predstavljat će radovi u časopisima, knjige, zbornici, katalozi i druge publikacije, izložbe, izlaganja na znanstvenim skupovima, a članovi projekta namjeravaju organizirati i dva znanstvena skupa te radionicu.]]></summary_hr><summary_en><![CDATA[The project Art and the State in Croatia from the Enlightenment to the Present aims to explore influences of the state regime on art production and interpretation of artworks and artistic heritage.Since the Croatian cultural and political space in the period from the late 18th century to 1991 formed part of different states (Austro-Hungarian Empire, first and second Yugoslavia, Independent State of Croatia, Kingdom of Italy), the project researchers will attempt to show the degree and nature of the impact the state-based bodies exerted on artistic production and cultural and educational policies related to visual arts.Croatian art will be contextualized with artistic developments in the neighboring countries or the areas of political association with Croatia, due to which the implementation of the project entails numerous field researches (urban space, museums, libraries, archives).In terms of its goals, the project is divided into two major groups of activities – research on the impact of the state on different areas of artistic production through commissions, grants and censorship, and the impacts on the process of artistic heritage production and care and on formal and informal education in the field of visual arts.In addition to the principal investigator the project includes 14 researchers (2 doctoral students and 6 postdoctoral researchers) for whom this project presents an opportunity for academic career development. By engaging researchers from heritage institutions (museums and conservation departments), the project contributes to the promotion of inter-institutional cooperation and ensures multidimensional views on intricate relationships between art and the state.Project results will be published in journals, books, proceedings, catalogues and the like, as well as through exhibitions and conferences. The team plans to organize two project-related scientific conferences and a workshop.]]></summary_en></project><project>
<id>14621</id><title_hr><![CDATA[Geni spužvi povezani s nastankom raka]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1187</user_id><user_firstLast_name>Kristian Vlahoviček</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-5588</code><acronim><![CDATA[CanSponGE]]></acronim><duration>27.06.2022 - 26.06.2026</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>865457</team_members_id><team_members_names><![CDATA[ Doktorand: Doris Brkić ]]></team_members_names><keywords_hr><![CDATA[evolucija, Metazoa, Porifera, spužve, tumori, evolucija raka, geni povezani s nastankom raka]]></keywords_hr><keywords_en><![CDATA[evolution, basal metazoans, Porifera, sponges, tumors, cancer evolution, cancer-related genes]]></keywords_en><summary_hr><![CDATA[Proučavanje ljudskih bolesti korištenjem životinja kao eksperimentalnih modela ključno je za razumijevanje uzroka, biologije i prevencije bolesti. Malo se zna o genima povezanim s nastankom raka kod beskralježnjaka, osobito kod najjednostavnijih životinja - &#39;&#39;bazalnih&#39;&#39; Metazoa. Posljednjih nekoliko godina raste zanimanje za proučavanje evolucije gena povezanih s nastankom raka budući da je široki repertoar tih gena već prisutan u genomima morfološki jednostavnih životinja. Većina ovih gena pojavila se tijekom dva glavna evolucijska događaja – s pojavom eukariota i pri prelasku u višestaničnost, tj. nastanku životinja. Stoga proučavanje gena povezanih s nastankom raka kod ljudi na nivou jednostavnijih organizama, kao što su spužve, jedna od najstarijih skupina životinja, pruža bolji uvid u njihovu evoluciju i osnovnu fiziološku funkciju. Spužve su morfološki najjednostavnije životinje, bez bilateralne simetrije, tkiva i organa, koje su se vrlo malo mijenjale tijekom evolucije. Usprkos tome, posjeduju kompleksan genom u kojem većina gena pokazuje visoku sačuvanost s homolozima kod kralježnjaka te stoga daju najbolji uvid u svojstva genoma i proteoma pretka svih Metazoa. Cilj projekta je identificirati i okarakterizirati spužvine proteine čiji su homolozi kod čovjeka povezani s nastankom raka kako bi dobili što bolji uvid u evoluciju raka. Ovakav inovativni pristup na relativno jednostavnom modelu pružit će nam uvid u osnovne fiziološke funkcije gena povezanih s nastankom raka, prije njihove diverzifikacije i specijalizacije kroz evoluciju životinja. Naše istraživanje gena spužvi povezanih s nastankom raka pomoći će u razjašnjavanju složenijih interakcija njihovih homologa kod ljudi i time objasniti moguće razloge njihovog onkogenog potencijala. Zbog važnog evolucijskog položaja spužvi na samoj bazi filogenetskog stabla životinja, svaki novi uvid u svojstva njihovih homologa povezanih s rakom poboljšat će naše razumijevanje ove bolesti kod ljudi.]]></summary_hr><summary_en><![CDATA[The use of animals as experimental models for human diseases is imperative for understanding the causes, biology, and prevention of diseases. To date, little is known about the functions of cancer-related genes in invertebrates, especially in non-bilaterian Metazoa. In the last few years, the interest in genes associated with cancer from an evolutionary perspective is increasing, since it has been shown that many of them were already present in simple non-bilaterian animals. The majority of these genes appeared in two major evolutionary transitions - the emergence of eukaryotes and the transition to multicellularity in the animal lineage. Therefore, studying cancer-related genes in organisms at the base of Metazoa, such as sponges, can help unravel the original function as well as the evolution of those genes. Sponges are morphologically simple animals, with no tissues and organs, which have changed little during evolution. Despite that, sponges possess complex genomes with many genes highly similar to their vertebrate homologs. Therefore, they provide an invaluable insight into the metazoan last common ancestors’ genome and proteome features. The aim of the proposed project is to identify and characterize sponge homologs of human cancer-related genes and thus gain a clearer picture of the evolution of cancer. Such an innovative approach using a simple model system will provide insights into the original ancestral physiological functions of cancer-related genes before their diversification and specialization in &#39;&#39;higher&#39;&#39; animals. Our understanding of the basic physiological properties of cancer-related genes in simple animals will aid in unravelling complex interactions of their human homologs and thus elucidate possible causes of their oncogenic potential. Due to the &#39;&#39;basal&#39;&#39; phylogenetic position of sponges within animals, new insights in the properties of their cancer-related homologs will substantially improve our understanding of this disease.]]></summary_en></project><project>
<id>14622</id><title_hr><![CDATA[Urbane budućnosti: zamišljanje i aktiviranje mogućnosti u nemirnim vremenima]]></title_hr><title_en><![CDATA[]]></title_en><user_id>311</user_id><user_firstLast_name>Valentina Gulin Zrnić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-8654</code><acronim><![CDATA[]]></acronim><duration>11.10.2021 - 10.02.2026</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Etnologija i antropologija, </scie_field_hr><scie_field_en>Ethnology and anthropology, </scie_field_en><institution_hr><![CDATA[Institut za etnologiju i folkloristiku]]></institution_hr><institution_en><![CDATA[Institute of Ethnology and Folklore Research in Zagreb]]></institution_en><team_members_id>865089</team_members_id><team_members_names><![CDATA[ Doktorand: Mirna Tkalčić Simetić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>14623</id><title_hr><![CDATA[Molekularni mehanizmi imunološkog odgovora i aktivacije inflamasoma u Parkinsonovoj bolesti]]></title_hr><title_en><![CDATA[]]></title_en><user_id>2684</user_id><user_firstLast_name>Fran Borovečki</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-5343</code><acronim><![CDATA[IMMUNE PD]]></acronim><duration>01.11.2021 - 01.05.2026</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>865171</team_members_id><team_members_names><![CDATA[ Doktorand: Sarah Meglaj ]]></team_members_names><keywords_hr><![CDATA[genomika, Parkinsonova bolest, alfa sinuklein, NGS, imunološki odgovor, dendritičke stanice, CD4+ T limfociti, inflamasomi]]></keywords_hr><keywords_en><![CDATA[genomics, Parkinson&#39;s disease, alpha synuclein, NGS, immune response, dendritic cells, CD4+ T lymphocytes, inflammasome]]></keywords_en><summary_hr><![CDATA[Parkinsonova bolest (PB) je progresivna neurodegenerativna bolest karakterizirana nakupljanjem proteina i degeneracijom dopaminergičkih neurona. Temeljni mehanizmi koji uzrokuju PB nisu u potpunosti jasni. Pokazano je da trajni upalni odgovor igra važnu ulogu u patogenezi PB rezultirajući gubitkom dopaminergičkih neurona. Do danas je pokazano da je nekoliko tipova imunoloških stanica uključeno u progresiju PB. Dendritičke stanice (DS) su spona između imunološkog odgovora i neurodegenerativnih procesa, a infiltracija T limfocita propagira neurodegeneraciju generiranjem štetnog imunološkog odgovora. Nadalje, pokazana je snažna korelacija između inflamasoma i neurodegeneracije što ukazuje na moguću povezanost autoimunog odgovora s gubitkom neurona. Cilj projekta je definirati i opisati temeljne mehanizme imunološkog odgovora i aktivacije inflamasoma u oboljelih od PB pomoću naprednih genomskih metoda kako bi se rasvijetlili putovi uključeni u regulaciju imunološkog sustava. Osim toga, analizirat ćemo potencijalne proteinske biomarkere iz krvi koji sudjeluju u upalnim putovima i povezati rezultate s analizom genske ekspresije. Otkrivene varijante gena i različiti ekspresijski profili odabranih subpopulacija imunoloških stanica dalje će se karakterizirati pomoću staničnih linija, te na uzorcima humanih mozgova. Konkretno, istražit ćemo imunološki odgovor utišavanjem i pojačanom ekspresijom odabranih gena u DS linijama generiranim od PB pacijenata i zdravih kontrolnih ispitanika. Dodatno, želimo definirati uzročno-posljedičnu vezu između nakupljanja aSyn i imunološkog odgovora utišavanjem istaknutih gena u SH-SY5Y staničnoj liniji i u primarnim kortikalnim neuronima. Konačno, da bismo potvrdili mehanicističke rezultate, posljednji korak bit će provođenje imunohistokemijskih eksperimenata na preparatima humanih mozgova. Rezultati projekta će pomoći u identificiranju novih potencijalnih ciljeva za neuroprotektivno liječenje usmjereno na modulaciju imunološkog odgovora.]]></summary_hr><summary_en><![CDATA[Parkinson&#39;s disease (PD) is a progressive neurodegenerative disease characterized by proteinaceous aggregates and degeneration of dopaminergic neurons. The underlying mechanisms causing PD have not been fully elucidated. Persistent inflammation is a major aggravating factor in PD resulting in the loss of dopaminergic neurons. To date, several immune cell types have been shown to be responsible for driving PD progression. Dendritic cells (DCs) lie at the intersection of the immune response and the neurodegenerative process while T cell infiltration generates a harmful immune response. Additionally, there is a strong correlation between inflammasomes and neurodegeneration indicating a possible association between the autoimmune response and neuronal loss. The aim of the project is to identify and characterize underlying mechanisms of immune response and inflammasome activation in PD patients using genomic analyses in order to decipher the pathways involved in the immune system regulation. Furthermore, we will analyze potential protein biomarkers from blood involved in inflammatory pathways and correlate the results with gene expression analyses. The detected gene variants and differential expression profiles of selected immune cell subpopulations will further be characterized using cell lines, as well as in human brain samples. In particular, we will validate the immune response using the knockdown and overexpression approach in DC lines generated from PD patients and healthy controls. In addition, we aim to define the causal relationship between aSyn accumulation and the immune response by knockdown of identified genes in the SH-SY5Y cell line and primary cortical neurons. Finally, in order to validate our mechanicistic findings, the last step will be to perform immunohistochemistry experiments on human brain sections. The results of the project may help identify novel putative targets for development of neuroprotective treatments by modulating the immune response.]]></summary_en></project><project>
<id>14627</id><title_hr><![CDATA[Terapijski potencijal neurosteroida i neurotrofina u demenciji]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1023</user_id><user_firstLast_name>Matea Nikolac Perković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-2553</code><acronim><![CDATA[TePoNeDe]]></acronim><duration>11.10.2021 - 11.04.2026</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>865092</team_members_id><team_members_names><![CDATA[ Doktorand: Tina Miloš ]]></team_members_names><keywords_hr><![CDATA[neurosteroidi DHEA i DHEAS, neurotrofin BDNF, demencija, neuroprotekcija, stanični i animalni modeli, ispitanici ]]></keywords_hr><keywords_en><![CDATA[neurosteroids DHEA and DHEAS, neurotrophin BDNF, dementia, neuroprotection, cellular and animal models, human subjects]]></keywords_en><summary_hr><![CDATA[Demencija predstavlja sindrom globalnog i progresivnog propadanja kognitivnih sposobnosti, koji obično pogađa starije osobe. Kako se tijek demencije za sada ne može zaustaviti te s obzirom na ubrzano starenje stanovništva i produljenje životnog vijeka, u skoroj budućnosti demencija će postati jedan od vodećih globalnih problema. Neurosteroidi poput dehidroepiandrosterona (DHEA) i njegovog sulfata (DHEAS), kao i neurotrofini poput moždanog neurotrofnog čimbenika (BDNF), uključeni su u brojne važne funkcije mozga poput neuralne plastičnosti, učenja, pamćenja i ponašanja te pokazuju potencijal u prevenciji i liječenju demencija. Cilj projekta je istražiti neuroprotektivni potencijal i mehanizme djelovanja DHEA(S) i BDNF u demenciji, kombinacijom staničnih, animalnih i istraživanja na ispitanicima. Stanični i molekularni mehanizmi protektivnog djelovanja DHEA(S) i BDNF s posebnim naglaskom na ulogu PI3K signalnog puta istražiti će u primarnoj kulturi neurona C57BL/6 miša tretiranoj Aß-oligomerima kao in vitro modelu Alzheimerove bolesti (AB). Transgeničnim animalnim modelom AB (3xTg-AD miševi), istražiti će se mehanizmi protektivnog djelovanja DHEA(S), s fokusom na promjene BDNF-a i PI3K signalnog puta, in vivo testiranjem kognitivnih funkcija testovima ponašanja te ex vivo analizom patohistoloških, neurokemijskih i strukturnih promjena u tkivu i prerezima mozga, kao i metabolomskog profila u plazmi miševa. U ispitanika sa demencijama i blagim spoznajnim poremećajem (MCI), istražiti će se genetski (BDNF i SULT2A polimorfizmi) i epigenetski (DNA metilacija BDNF promotora) čimbenici uključeni u ekspresiju i regulaciju BDNF i DHEA(S) te povezanost njihove koncentracije u plazmi sa simptomima demencije. Dobiveni rezultati trebali bi pridonijeti boljem razumijevanju složene patofiziologije demencija, razvoju lako dostupnih biokemijskih, metabolomskih i (epi)genetičkih biomarkera u svrhu ranog otkrivanja i praćenja bolesti te novih pristupa u prevenciji i liječenju demencija.]]></summary_hr><summary_en><![CDATA[Dementia is a syndrome of global and progressive deterioration of cognitive skills, which usually affects the elderly. As dementia course for now cannot be halted, given the aging population and increased life expectance, dementia will become one of the leading global problems in near future. Neurosteroids dehydroepiandrosterone (DHEA) and its sulphate (DHEAS), as well as neurotrophin brain derived neurotrophic factor (BDNF) are involved in numerous brain functions such as neural plasticity, learning, memory and behaviour, showing potential in dementia prevention and treatment. The project aims to elucidate neuroprotective effects and mechanisms of DHEA(S) and BDNF in dementia by combining cellular, animal and human research. Cellular and molecular mechanisms of DHEA(S) and BDNF protective effects with emphasis on PI3K-Akt signalling pathway will be evaluated using primary C57BL/6 mouse neuronal culture treated with Aß-oligomers as in vitro model of Alzheimer’s disease (AD). Using transgenic animal AD model (3xTg-AD mice), mechanisms of DHEA(S) protective actions with focus on alternations in BDNF and PI3K signalling pathway, will be evaluated in vivo by behavioral testing of cognitive functions and ex vivo by analysis of pathohystological, neurochemical and structural changes in brain tissue and slices, as well as metabolomic profile in mouse plasma. In subjects with dementia and mild cognitive impairment (MCI), genetic (BDNF and SULT2A polymorphisms) and epigenetic (BDNF DNA methylation) factors, involved in BDNF and DHEA(S) expression and regulation, as well as association of their plasma concentrations with dementia symptoms will be evaluated. Obtained results should contribute to better understanding of complex cellular and molecular pathophysiology of dementia, development of easy available biochemical, metabolomic and (epi)genetic biomarkers for an early detection and disease course monitoring, as well as novel approaches in dementia prevention and treatment.]]></summary_en></project><project>
<id>14628</id><title_hr><![CDATA[Razvoj novih rješenja za karakterizaciju i zaštitu brončane kulturne baštine  izložene vanjskom okolišu]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6981</user_id><user_firstLast_name>Sanja Martinez</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-8232</code><acronim><![CDATA[BroCH]]></acronim><duration>01.08.2021 - 01.03.2026</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Kemijsko inženjerstvo, </scie_field_hr><scie_field_en>Chemical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet kemijskog inženjerstva i tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Chemical Engineering and Technology]]></institution_en><team_members_id>862801</team_members_id><team_members_names><![CDATA[ Doktorand: Ines Šoljić ]]></team_members_names><keywords_hr><![CDATA[kulturna baština, korozija, korozijska zaštita, organske prevlake, elektrokemijske tehnike]]></keywords_hr><keywords_en><![CDATA[cultural heritage, corrosion, corrosion protection, organic coatings, electrochemical techniques]]></keywords_en><summary_hr><![CDATA[Brončane skulpture izložene na javnim površinama su važan dio kulturne baštine, no korozivna gradska atmosfera uzrokuje njihovu degradaciju. Cilj ovog projekta je razviti nova rješenja za njihovu karakterizaciju te unapređivanje postupaka njihove zaštite. U tu svrhu, najprije će se spektroskopskim i elektrokemijskim tehnikama provesti detaljna karakterizacija izabranih urbanih brončanih skulptura na temelju kojih će se definirati uvjeti provedbe laboratorijskih istraživanja. Potom će se istražit mogućnost primjene dugolančanih organskih kiselina za poboljšanje adhezije organskih premaza, na bazi vode kao i na bazi organskih otapala, na brončanu podlogu čime bi se osigurala njena bolja i dugotrajnija korozijska zaštita. Utvrdit će se uvjeti pri kojima dolazi do nastanka čvrsto vezanog zaštitnog sloja organske kiseline u ovisnosti o metodi nanošenja i sastavu podloge te da li interakcija funkcionalnih skupina organske kiseline i premaza može dovesti do poboljšanja adhezije premaza. Zaštitna svojstva modificiranog premaza istražit će se ubrzanim korozijskim ispitivanjima uz primjenu ionizirajućeg zračenja i industrijske komore kao i elektrokemijskim ispitivanjima u elektrolitu koji simulira urbanu kišu.Dodatni inovativni aspekt ovog projekta je razvoj senzorskog dijela uređaja za određivanje korozijske stabilnosti brončanih skulptura. Elektrokemijske metode su temeljne metode za karakterizaciju korozijske stabilnosti materijala, no za njihovu provedbu uglavnom je nužno koristiti elektrokemijsku ćeliju s vodenim elektrolitom što otežava primjenu na realnim objektima zakrivljene geometrije. U projektu će se ispitati mogućnost konstruiranja jednostavne elektrokemijske ćelije s elektrolitom na bazi hidrogela odnosno vodljivom pastom koja bi bila primjenjiva za provođenje nedestruktivnih elektrokemijskih istraživanja brončanim skulpturama. Ćelija će se testirati na laboratorijskim i realnim uzorcima kako bi se utvrdila njena primjenjivost u praksi.]]></summary_hr><summary_en><![CDATA[Bronze sculptures exposed in public areas are an important part of cultural heritage, but corrosive urban atmospheres lead to their degradation. The aim of this project is to develop new solutions for their characterisation and to improve methods for their protection.Firstly, a detailed spectroscopic and electrochemical material characterization of selected bronze sculptures will be conducted in order to define key parameters for laboratory studies.Then the possibility of using long-chain organic acids for improved adhesion of solvent and water-based organic coatings on the bronze substrate will be examined. The conditions under which a strongly bonded organic acid layer is formed on the bronze surface will be determined, as well as whether the interaction between the functional groups of organic acids and coatings can lead to improved adhesion of the coating. The protective properties of the modified coatings will be investigated by accelerated corrosion tests using ionizing irradiation and an industrial chamber, as well as by electrochemical tests in electrolytes that simulate urban rain.An additional innovative aspect of this project is the development of an electrochemical cell for corrosion measurements that could be easily applied to bronze sculptures. Electrochemical methods are essential methods for characterizing the corrosion stability, but require the use an electrochemical cell with aqueous electrolyte, which makes it difficult to apply on real objects of curved geometry. This project will explore the possibility of designing a simple electrochemical cell with hydrogel or conductive paste electrolyte that would be applicable for conduction of non-destructive electrochemical testing on bronze sculptures. The cell will be tested on laboratory samples as well as on sculptures in order determine its practical applicability.]]></summary_en></project><project>
<id>14629</id><title_hr><![CDATA[Racionalan dizajn prirodnih eutektičkih otapala za pripremu i formulaciju kiralnih lijekova  ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5443</user_id><user_firstLast_name>Kristina  Radošević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-3797</code><acronim><![CDATA[NADESChiralDrug]]></acronim><duration>15.10.2021 - 15.04.2026</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Biotehnologija, </scie_field_hr><scie_field_en>Biotechnology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Food Technology and Biotechnology]]></institution_en><team_members_id>865178</team_members_id><team_members_names><![CDATA[ Doktorand: Martina Bagović ]]></team_members_names><keywords_hr><![CDATA[biokataliza, kiralni sintoni, NADES, zelena otapala, THEDES]]></keywords_hr><keywords_en><![CDATA[biocatalysis, chiral synthon, NADES, green solvents , THEDES]]></keywords_en><summary_hr><![CDATA[Moderna kemijska i farmaceutska industrija zahtjeva visoki stupanj enantiomerne čistoće biološki aktivnih kiralnih spojeva stoga se razvijaju različite metode za proizvodnju i formulaciju kiralnih lijekova. Uvidom u suvremenu literaturu očituje se sve veći interes za nove i ekološki prihvatljive pristupe u pripravi i formulaciji kiralnih lijekova: primjena prirodnih eutektičkih otapala (NADES) kao medija za njihovu pripravu ili kao pomoćnog sredstva za isporuku kiralnog lijeka kroz sintezu terapeutskih eutektičkih otapala (THEDES). Međutim, unatoč obećavajućim rezultatima primjene ovih otapala, dosadašnja potraga za idealnim NADES za određeni reakcijski sustav vođena je empirijskim pristupom pokušaja i pogrešaka, pri čemu je sistematsko istraživanje odnosa struktura-aktivnoststruktura-aktivnost NADES, kao okosnice racionalnog dizajna ovih otapala za specifične namjene, još uvijek u povojima. To je izravna posljedica nedostatka temeljnih znanja o ovim otpalima, a što onemogućava potpuno razumijevanje njihove mehanističke uloge u raznim biotehnološkim procesima. Stoga, prikupljanje podataka o osnovnim svojstvima NADES te razvoj matematičkih metoda kao alata za dizajniranje otapala s optimalnim svojstvima predstavlja imperativ za njihovu industrijsku primjenu. Na temelju navedenog, glavni cilj predloženog multidisciplinarnog Projekta jest stjecanje znanja o NADES te istraživanje prednosti njihove primjene u zelenom pristupu priprave i formulacije kiralnih lijekova. Kako bi ostvarili zadane ciljeve projekta, definirani su sljedeći specifični ciljevi: (1) racionalni dizajn NADES za pripravu i formulaciju kiralnog lijeka (2) implementacija NADES u enzimski kataliziranoj pripravi intermedijera kiralnog lijeka (3) razvoj THEDES kao poboljšane formulacije kiralnog lijeka. Ovo multidisciplinarno istraživanje koje uključuje organske kemičare, biotehnologe i farmaceute bilo bi dokaz koncepta NADES kao otapala/pomoćne tvari u pripravi i formulaciji enantiomerno čistih lijekova.]]></summary_hr><summary_en><![CDATA[Nowadays, single-enantiomer drugs have become the standard in pharmaceutical companies when working with compounds featuring stereogenic centers, mobilizing chemical and biotechnological industry to develop versatile methods for production and formulation of biologically active chiral compounds of high enantiomeric purity. Overview of current literature on chiral drug production and formulation reveals exciting, new and green approach: the use of natural deep eutectic solvents (NADES) as medium for biotechnological preparation of chiral biologically active compounds and as auxiliaries in development of chiral drug delivery system through designing therapeutic deep eutectic solvents (TEHDES). However, this exciting research field still faces several great challenges. Namely, approaches used so far for screening ideal NADES have been governed by time consuming empirical methods, while systematic investigation in NADES structure-activity relationship, as a backbone for rational design of these solvents, is still lacking. Extension of fundamental research on NADES solvent properties, as well as development of mathematical models as tools for designing ideal NADES for specific purpose becomes an imperative for industrial use of NADES. Based on the stated above the aim of proposed Project is to is to demonstrate the advantages of using NADES as green approach in the biotechnological preparation and formulation of chiral drugs. To achieve Project goals, specific objectives of the Project are, therefore, the following: (1) rational design of NADES for chiral drug preparation and formulation (2) implementation of NADES in enyzme-catalyzed preparation of chiral drug intermediates (3) development of THEDES as improved formulation of chiral drug. This multidisciplinary research which includes chemists, biotechnologists and pharmacist would be our proof-of-concept of the NADES promising use as solvents/auxiliaries in enantiopure drug preparation and formulation. ]]></summary_en></project><project>
<id>14630</id><title_hr><![CDATA[Application of Nanobiotechnology for Nutritional Supplementation with Selenium]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3927</user_id><user_firstLast_name>Dubravka Vitali Čepo</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-6801</code><acronim><![CDATA[NutriNTENSe]]></acronim><duration>01.11.2021 - 31.10.2025</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Farmacija, </scie_field_hr><scie_field_en>Pharmaceutical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Farmaceutsko-biokemijski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Pharmacy and Biochemistry]]></institution_en><team_members_id>865170</team_members_id><team_members_names><![CDATA[ Doktorand: Nikolina Golub ]]></team_members_names><keywords_hr><![CDATA[selen, biofortifikacija, nanobiotehnologija, povrće, suplementacija hrane, prehrambeni otpad]]></keywords_hr><keywords_en><![CDATA[selenium, biofortification, nanobiotechnology, vegetables, nutritional supplementation, food waste]]></keywords_en><summary_hr><![CDATA[Selen (Se) je bitan mikroelement koji igra važnu ulogu u metabolizmu i mnogim drugim vitalnim funkcijama. Zbog svoje zaštitne aktivnosti tijekom imunološkog odgovora te kod karcinoma, Se se koristi kao dodatak prehrani. Budući da su biljke glavni izvor Se za ljude i životinje, različite strategije poput biofortifikacije i korištenja biljnih ekstrakata se koriste za razvoj prehrambenih dodataka na bazi Se. Biološka raspoloživost selena varira ovisno o nekoliko čimbenika, uključujući kemijski oblik Se, druge hranjive komponente u hrani, fiziološki status i status Se u organizmu. Glavne zapreke u postizanju optimalnog unosa Se su visoko varijabilni sadržaj u različitim vrstama hrane i uska sigurnosna granica unosa različitih Se oblika. Nanotehnologija omogućuje primjenu selenovih nanočestica (SeNPs), koje posjeduju jaču antioksidativnu aktivnost i nižu toksičnost u odnosu na druge oblike Se. NutriNTENSe projekt ima za cilj istražiti djelotvornost i sigurnost inovativnih nutraceutika i funkcionalne hrane na bazi SeNPs primjenom nanobiotehnoloških metoda. To će se postići razvojem dviju inovativnih klasa Se-nutraceutika: funkcionalnog biofortificiranog povrća sa SeNPs (FBVegs) i Se-nanoceutika (SeNCes) korištenjem ekstrakata prehrambenog otpada za biogenu sintezu SeNPs. Oba tipa Se-nutraceutika bit će podvrgnuta in vitro i/ili in vivo ispitivanjima kako bi se istražila njihova biokompatibilnost, sigurnost, farmakokinetička svojstva i farmakološka aktivnost u usporedbi sa selenatom i/ili kemijski sintetiziranim SeNPs. Osim toga, procijeniti će se moguće sinergističko djelovanje biogenih SeNPs i specifičnih bioaktivnih spojeva iz NutriNTENSe biljaka ili ekstrakata. Rezultati dobiveni NutriNTENse projektom biti će od velike koristi za potrošače, poljoprivredne proizvođače i prehrambenu industriju kao krajnje korisnike ishoda projekta. Treba istaknuti da NutriNTENse ima zeleni karakter s ciljem povećanja primjene zdravih i ekološki prihvatljivih proizvoda.]]></summary_hr><summary_en><![CDATA[Selenium (Se) is an essential trace element playing important role in metabolism and many other vital functions. Due to its protective activity in immune response and cancer, it is widely used as a diet supplement. As plants are the main dietary source of Se for humans and animals, different strategies such as biofortification and plant-based extracts are used to develop Se dietary supplements. Selenium bioavailability varies depending on several factors including chemical form of Se, other dietary components, physiological status and selenium status of the organism. The major obstacles in achieving optimal Se intake are highly variable Se content in different food types and narrow safety margin of supplemental Se forms. Nanotechnology enables application of selenium nanoparticles (SeNPs), due to their enhanced antioxidant activities and lower toxicity as compared to other Se forms. NutriNTENSe project aims to investigate the efficacy and safety of innovative SeNPs-based nutraceuticals and functional food using nanobiotechnological tools. This will be achived by following development of two innovative classes of Se-nutraceuticals: functional SeNPs biofortified vegetables (FBVegs) and Se-nanoceuticals (SeNCes) using food waste extracts for biogenic synthesis of SeNPs. Both types of Se-nutraceuticals will be subjected to in vitro and/or in vivo testings to investigate their biocompatibility, safety, pharmacokinetic properties and pharmacological activity compared to selenite and chemically synthesized SeNPs. In addition, possible synergistic action of biogenic SeNPs and specific bioactive compounds found in NutriNTENSe plants and extracts will be evaluated. Results obtained within NutriNTENse will be of great interest for consumers, agricultural producers and food industry as final beneficiaries of project outcomes. It should be highlighted that NutriNTENse is green project aimed to increase implementation of healthy and environment friendly products.]]></summary_en></project><project>
<id>14631</id><title_hr><![CDATA[Smart EC - dijagnostički sustav za ispitivanje metodom vrtložnih struja]]></title_hr><title_en><![CDATA[]]></title_en><user_id>21443</user_id><user_firstLast_name>Željka Lučev Vasić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-5017</code><acronim><![CDATA[]]></acronim><duration>04.10.2021 - 03.10.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>865105</team_members_id><team_members_names><![CDATA[ Doktorand: Matija Roglić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>14632</id><title_hr><![CDATA[Povećanje učinkovitosti, smanjenje štetnih emisija i hibridizacija brodskog energetskog sustava]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3698</user_id><user_firstLast_name>Gojmir Radica</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-8077</code><acronim><![CDATA[MOPTIHYB]]></acronim><duration>04.11.2021 - 03.11.2025</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, </scie_field_hr><scie_field_en>Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Fakultet elektrotehnike, strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Electrical Engineering, Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>865046</team_members_id><team_members_names><![CDATA[ Doktorand: Tino Vidović ]]></team_members_names><keywords_hr><![CDATA[Energetska učinkovitost, štetne emisije, hibridizacija, brodski pogoni, energetski sustavi]]></keywords_hr><keywords_en><![CDATA[Efficiency improvement, Emission reduction, Hybridization, Marine engines, Energy systems]]></keywords_en><summary_hr><![CDATA[Svrha istraživanja je istražiti mogućnosti poboljšanja energetske učinkovitosti i smanjenja emisija štetnih plinova brodskih energetskih sustava, primjenom optimizacije u stvarnom vremenu i inovativnim tehnologijama s fokusom na primjenu vodika i gorivnih članaka (Fuel Cell, FC). Dizelski motori su danas i bit će ubuduće glavni pogonski stroj korišten u pomorskom transportu. Glavni problemi s kojim se proizvođači brodskih dizelskih motora danas susreću su energetska učinkovitost i zaštita okoliša. Kao potencijalno rješenje za smanjenje globalne (CO2) i lokalne (NOx, čađa) razine emisija štetnih ispušnih plinova, predložena su alternativna goriva i hibridizacija sustava. Jedan od glavnih ciljeva istraživanja je istražiti moguću optimizaciju performansi i emisija motora s unutarnjim izgaranjem, koji rade u stvarnim uvjetima. Fokus će biti na dizelskim motorima, jer su konvencionalni brodski pogonski sustavi uglavnom opremljeni brodskim dizelskim motorima. Veliki dvotaktni brodski dizel motori su problematični za modeliranje zbog neprilagođenosti primjene postojećih modela na velike sporokretne dvotaktne dizelske motore, jer postoji veliki broj parametara koji utječe na proces izgaranja, poput oblika otvora i ispušnih ventila, radni protok, te komore za izgaranje, pa se stoga vrlo malo istraživača bavi ovim istraživanjem. Drugi predmet ovog istraživanja su alternativna goriva i inovativni brodski energetski sustavi s ciljem poboljšanja učinkovitosti i smanjenja emisija štetnih plinova brodskih energetskih. Tehnologija koja ima veliki potencijal u pridonošenju smanjenja utjecaja prometnog sektora na okoliš je FC tehnologija, posebno FC s protonskom membranom (Proton Exchange Membrane ili Polymer Electrolyte Membrane, PEM). Analiza životnog vijeka FC pogonskih sustava, kao i optimalna strategija FC integracije u hibridnom sustavu, bit će jedan od fokusa našeg istraživanja.]]></summary_hr><summary_en><![CDATA[The purpose of the research is to investigate the possibilities of improving the energy efficiency and reducing emissions of marine power systems by the implementation of real-time optimization and innovative technologies with the focus on hydrogen and fuel cell application. Diesel engines are today and will be in the future the main power supply in sea transport. Energy conservation and environmental protection are the main problems that engine manufacturers are facing. Researchers have been making a lot of effort over the last decades to analyse energy conversion in internal combustion engines, especially in large two-stroke engines. Alternative fuels and hybridization have been suggested as a potential solution to reduce both global (CO2) and local (NOx, soot) exhaust gas emissions from internal combustion engines. The main objective of the research is to investigate the possible optimization of performance and emissions of an IC engine running under real conditions. The focus will be on Diesel engines, as the conventional marine propulsion systems are mainly equipped with marine Diesel engines. The other important objective is to investigate alternative fuels and innovative marine energy systems to improve efficiency and reduce emissions of energy power pack in a marine application. A technology that has great potential in reducing the environmental impact of the transport sector is hydrogen-fueled fuel cell technology especially polymer electrolyte membrane (PEM) fuel cell. Life cycle analysis of fuel cell propulsion systems, as well as the optimum integration strategy of the fuel cell in a hybrid system, will be in focus of our research.]]></summary_en></project><project>
<id>14634</id><title_hr><![CDATA[Genetske, gospodarske i društvene interakcije programa očuvanja lokalnih pasmina]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3970</user_id><user_firstLast_name>Marija Cerjak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-3396</code><acronim><![CDATA[GGD LocBreed]]></acronim><duration>01.10.2021 - 01.10.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Agronomski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Agriculture]]></institution_en><team_members_id>865087</team_members_id><team_members_names><![CDATA[ Doktorand: Gabriela Sušac ]]></team_members_names><keywords_hr><![CDATA[Lokalne pasmine, programi očuvanja, genetska vrijednost, kompetitivnost, društveni stavovi]]></keywords_hr><keywords_en><![CDATA[Local breeds, conservation programs, genetic value, competitiveness, social attitudes]]></keywords_en><summary_hr><![CDATA[Najveći broj lokalnih pasmina domaćih životinja je tijekom dvadesetog stoljeća bio zanemaren, prvenstveno radi njihove niže proizvodne konkurentnosti. Danas društvo cijeni lokalne pasmine kao vrijedno genetsko i kulturno naslijeđe, važno za sigurnost proizvodnje hrane, održavanje prepoznatljivosti ruralnih prostora i bioraznolikosti, ne zanemarujući njihovu aktualnu ili moguću gospodarsku važnost. Neke lokalne pasmine zadnjih desetljeća dovedene na rub opstanka te društvo nastoji javnim sredstvima potaknuti razvoj održivih sustava proizvodnje ugroženih lokalnih pasmina. Dosadašnja iskustva u razvoju održivih sustava zaštite lokalnih pasmina naglašavaju potrebu uravnoteženog i višestranog fokusiranja na sve sudionike konzervacijskih programa. Predloženo znanstveno istraživanje ima za cilj na primjeru pet hrvatskih lokalnih pasmina (istarsko govedo, buša, primorsko-dinarski i istarski magarac, hrvatski posavac) smještenih na različitim geografskim područjima utvrditi genetske, gospodarske i društvene indikatore lokalnih pasmina te utvrditi  interakcije utvrđenih indikatora. Za procjenu genetskih indikatora koristiti će se analiza rodovničkih zapisa, genetipizacija mikrosatelita, te određenih polimorfnih genskih lokusa. Proizvodni indikatori procijeniti će se prikupljanjem fenotipskih deskriptora, deskriptora karakteristika trupa prikupljenih na liniji klanja te kakvoće mesa. Analizom kemijskog sastava mesa te promjenama u sastavu masnih kiselina i aminokiselina tijekom zrenja mesa utvrditi će se utjecaj načina i dužine zrenja mesa na fizikalno-kemijske procese u mesu, što će biti iskoristivo u unapređenju kakvoće mesa lokalnih pasmina i povećanju njihove kompetitivnosti. Projektom je predviđeno utvrđivanje stavova različitih društvenih skupina. Najvažnije postignuće predloženog projekta je utvrđivanje interakcije pasminskih genetskih i proizvodnih pokazatelja sa stavovima društvenih skupina.]]></summary_hr><summary_en><![CDATA[Most local breeds of domestic animals were neglected during the twentieth century, primarily because of their lower production competitiveness. Today, local breeds are valued by society as a valuable genetic and cultural heritage, important for the safety of food production, maintaining the distinctiveness of rural areas and biodiversity, without neglecting their current or potential economic importance. Some local breeds that have been brought to the brink of survival in recent decades and society seek to promote, through public funds, the development of sustainable production systems for endangered local breeds. Past experiences in developing sustainable systems for protecting local breeds emphasize the need for a balanced and multilateral focus on all conservation program participants. The proposed scientific research aims at the example of five Croatian local breeds (Istrian cattle, Busha, Littoral-Dinaric and Istrian donkey, Posavina horse) located in different geographical areas to identify genetic, economic and social indicators of local breeds and to identify interactions of established indicators. Pedigree record analysis, genotyping, and certain polymorphic gene loci will be used to evaluate genetic indicators. Production indicators will be evaluated by collecting phenotype descriptors, descriptors of carcass characteristics at the slaughter line and descriptors of meat quality. The analysis of the chemical meat composition and changes in the composition of fatty acids and amino acids during the ‘meat aging’ will determine the effect of the procedure and length of meat ageing on physico-chemical processes in meat. Outcomes will be useful in improving the meat quality of local breeds and increasing their competitiveness. The project envisages establishing the attitudes of social groups. The most important achievement of the proposed project is to determine the interaction of breed, genetic and production indicators with the attitudes of social groups.]]></summary_en></project><project>
<id>14635</id><title_hr><![CDATA[Nova generacija poluvodičkih elemenata i integriranih sklopova za eru Interneta stvari]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6955</user_id><user_firstLast_name>Tomislav Suligoj</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-6927</code><acronim><![CDATA[NexGenSemi]]></acronim><duration>01.10.2021 - 31.03.2026</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>865117</team_members_id><team_members_names><![CDATA[ Doktorand: Borna Požar ]]></team_members_names><keywords_hr><![CDATA[Internet stvari, bipolarni tranzistor s horizontalnim tokom struje, pouzdanost, poluvodički fotodetektor, galij-nitrid, simulacije poluvodiča]]></keywords_hr><keywords_en><![CDATA[Internet of Things, Horizontal Current Bipolar Transistor, reliability, semiconductor photodetectors, gallium-nitride, semiconductor simulations]]></keywords_en><summary_hr><![CDATA[Cilj ovoga projekta je istražiti nove poluvodičke elemente i sklopove pogodne za primjenu na različitim nivoima Interneta stvari (eng. Internet-of-Things – IoT), od senzorskih čvorova, preo komunikacijskih sklopova, do elemenata za mrežnu infrastrukturu. Elektronički elementi i sklopovi za tako različite dijelove IoT sustava bit će istraženi u 3 područja: (i) Pouzdanost i pojačala snage u tehnologiji tranzistora sa horizontalnim tokom struje (HCBT), (ii) Projektiranje, karakterizacija i modeliranje blisko infracrvenih, vidljivih i UV fotodetektorskih prednjih krajeva, i (iii) Modeliranje i primjene GaN HEMT-ova.Doherty pojačalo snage i pojačalo za praćenje envelope kao primjeri visokoefikasnih RF pojačala snage za modulacije s velikim omjerom maksimalne i prosječne snage projektirat će se u HCBT tehnologiji koja ima nisku cijenu proizvodnje, a vrlo visoke performanse. To će biti prva RF pojačala snage s HCBT-ovima čime će se pokazati prikladnost tehnologije za sklopove s velikim signalom. Dodatno će se proučavati i pouzdanost HCBT elemenata s obzirom na pobudu jakim RF signalom i zračenjima.Uz proširenje našeg jedinstvenog električkog modela PureB materijala na siliciju za UV detektore, predloženi projekt bit će usmjeren i na visoko-osjetljive, blisko infra-crvene detektore implementirane u čistom galiju i PureB (PureGaB) na germaniju (Ge) nanesenom na Si supstrat, kao i na projektiranje detektora jednog fotona i njegove sklopove za potiskivanje proboja.Modeliranje GaN HEMT-a bit će istraženo pomoću fizikalno-baziranih modela. Transport elektrona u kanalu HEMT-a bit će modeliran samo-konzistentnim simulacijama mehanizama raspršenja, sa korijenima u kvantnoj mehanici, koji će uzeti u obzir kvantno ograničenje, strukturu energetskih pojaseva i sve relevantne mehanizme raspršenja.S obzirom na dosadašnja postignuća naše grupe, mogu se očekivati publikacije u vodećim znanstvenim časopisima i konferencijama kao i prijave patenata.]]></summary_hr><summary_en><![CDATA[The aim of this project is to conduct a research on novel semiconductor devices and circuits suitable for the Internet-of-Things (IoT) applications at various levels, to cover sensor nodes, communication circuits and devices for network infrastructure. Electron devices and circuits for such different parts of IoT systems will be researched in 3 areas: (i) Device reliability and power amplifiers (PAs) in Horizontal Current Bipolar Transistor (HCBT) technology, (ii) Design, characterization and modeling of near-infrared, visible and UV photodetector front-ends, and (iii) Modeling and applications of GaN HEMTs.The Doherty and Envelope tracking PAs with their high-efficiencies for high peak-to-average-power-ratio modulations will be designed in low-cost, high-performance HCBT technology. These will be the first RF power amplifiers with HCBTs demonstrating the suitability of HCBT technology for large-signal RF applications. Additionally, the reliability of HCBT devices will be tested against high RF power stress and radiation stresses.Besides extending our unique electrical model of PureB-on-Silicon material for UV detectors, the focus in the proposed project will also be on high-sensitivity, near-infra-red (NIR) detectors implemented in pure gallium and PureB (PureGaB) on germanium (Ge) grown on Si substrate together with the design of single photon avalanche detectors (SPADs) and their quenching circuits.The modeling of GaN high electron mobility transistor (HEMT) will be researched by physics-based models. The transport of electrons in HEMT channel will be assessed by self-consistent carrier scattering simulations, rooted in quantum mechanics that will take into account quantum confinement, bandstructure effects and all relevant scattering mechanisms.Based on a track record of the group, the publications in the top journals and conferences in the field and patent applications can be expected in this project.]]></summary_en></project><project>
<id>14636</id><title_hr><![CDATA[Manganovi metalosenzori]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4270</user_id><user_firstLast_name>Branimir Bertoša</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-7190</code><acronim><![CDATA[MaMes]]></acronim><duration>10.11.2021 - 09.11.2025</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>865143</team_members_id><team_members_names><![CDATA[ Doktorand: Katarina Radman ]]></team_members_names><keywords_hr><![CDATA[metalosenzori, alosterija, molekularni mehanizam, transkripcijski faktor, homeostaza mangana u bakterijama, molekularna dinamika, metaloproteini]]></keywords_hr><keywords_en><![CDATA[metallosensors, allostery, molecular mechanism, transcriptional factor, manganese homeostasis in bacteria, molecular dynamics, metalloproteins]]></keywords_en><summary_hr><![CDATA[Manganovi metalosenzori su transkripcijski faktori odgovorni za regulaciju homeostaze mangana u mnogim bakterijama. Četiri manganova metalosenzora su u fokusu projekta, a izabrani su tako da su po dva metalosenzora međusobno homologni proteini od kojih je jedan iz patogene, a drugi iz bakterije koja je uglavnom bezopasna za čovjeka. Jedan par magnanovih metalosenzora tvore međusobno homologni MntR proteini iz bakterije Mycobacterium tuberculosis, uzročnika tuberkuloze, i Bacillus subtilis, nepatogene bakterije koja je sastavni dio crijevne flore kod ljudi. MntR metalosenzori su esencijalni za navedene bakterije. Drugi par tvore manganovi metalosenzori SloR iz bakterije Streptococcus mutans i ScaR iz bakterije Streptococcus gordonii koji su međusobno homologni i oba su od esencijalne važnosti za bakteriju. Bakterija Streptococcus mutans je glavni uzročnik karijesa. Alosterički mehanizmi manganovih metalosenzora i njihove interakcije s pripadnom DNA sekvencom istražit će se interdisciplinarnim pristupom koji uključuje računalne i eksperimentalne metode istraživanja. Od računalnih metoda koristit će se primarno simulacije molekularne dinamike te kvantno mehaničke metode u svrhu parametrizacije interakcija Mn2+ iona i proteina. Eksperimentalne metode koje će se koristiti za istraživanje u sklopu projekta su: izotermalna titracijska mikrokalorimetrija (ITC), UV/Vis spektrofotometrija, nuklearna magnetska rezonancija (NMR), elektronska paramagnetska rezonancija (EPR), fluorescencijska anizotropija (FA) te genetičke i biokemijske metode potrebne za dobivanje i pročišćavanje odgovarajuće količine proteina. S obzirom da se projekt bazira na temeljnom znanstvenom istraživanju, rezultati projekta imat će prvenstveno fundamentalni značaj. Međutim, s obzirom da su dva od četiri manganova metalosenzora esencijalni za patogene bakterije, rezultati projekta mogli bi predstavljati temelj za buduća farmakološka istraživanja.]]></summary_hr><summary_en><![CDATA[Manganese metallosensors are transcriptional factors that regulate manganese homeostasis in bacteria. The focus of the project is on two pairs of manganese metallosensors, each pair consisting of two homologous proteins, one from a pathogenic bacterium and the other from a bacterium that is mostly harmless for humans. We will study the MntR manganese metallosensors from Mycobacterium tuberculosis, the causative agent of tuberculosis, and Bacillus subtilis, a non-pathogenic bacterium that is part of the normal gut flora of humans. Both MntR proteins are essential for their bacteria and are homologues. Manganese metallosensors SloR from Streptococcus mutans, and ScaR from Streptococcus gordonii, are also homologous proteins and both are essential for bacteria. The bacterium Streptococcus mutans is the main causative agent of caries. Allosteric mechanisms of manganese metallosensors and their interactions with the target DNA sequences will be studied by interdisciplinary approach consisting of computational and experimental methods. Computational methods will mostly rely on molecular dynamics simulations. Quantum mechanics calculations will be used for parametrisation of interactions between manganese ions and proteins. Experimental methods will consist of: isothermal titration calorimetry (ITC), UV-Vis spectrophotometry, fluorescence anisotropy (FA), nuclear magnetic resonance (NMR) and electron paramagnetic resonance (EPR), preceded by molecular biology and biochemistry methods necessary to produce sufficient amounts of proteins. The expected results of the project will primary have impact on fundamental science. However, considering the fact that two out of four metallosensors are essential for pathogenic bacteria, the results of the project might serve as a basis for future pharmacological research. ]]></summary_en></project><project>
<id>14637</id><title_hr><![CDATA[Pametni sustavi za dostavu lijeka pri liječenju tumora kosti]]></title_hr><title_en><![CDATA[]]></title_en><user_id>12661</user_id><user_firstLast_name>Anamarija Rogina</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-8317</code><acronim><![CDATA[SmartCar]]></acronim><duration>01.08.2021 - 31.07.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Kemijsko inženjerstvo, </scie_field_hr><scie_field_en>Chemical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet kemijskog inženjerstva i tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Chemical Engineering and Technology]]></institution_en><team_members_id>865015</team_members_id><team_members_names><![CDATA[ Doktorand: Luka Dornjak ]]></team_members_names><keywords_hr><![CDATA[Dostavljači lijeka, hidrogel, terapeutski ioni, kompleksiranje, antitumorsko djelovanje]]></keywords_hr><keywords_en><![CDATA[Drug delivery systems, hydrogel, therapeutic ions, chelation, antitumor activity]]></keywords_en><summary_hr><![CDATA[Potreba za manje invazivnim liječenjem malignih bolesti potakla je nagli razvoj materijala kao potencijalnih dostavljača lijekova. Kemoterapija je konvencionalna metoda u liječenju tumorom zahvaćenog koštanog tkiva, osteosarkoma. Standardni postupci liječenja zasnivaju se na intravenoznoj ili oralnoj administraciji lijeka pri čemu se cijelo tijelo izlaže njegovom djelovanju prije dolaska na mjesto oboljenja. Pri tome lijek neizbježno djeluje na ostala tkiva povećavajući rizik od toksičnosti i neželjenih reakcija. Obećavajuća strategija poboljšanja terapije liječenja leži u primjeni manje količine lijeka na ciljano mjesto bez interakcija s okolnim tkivom. Ovaj projekt predlaže razvoj pametnih dostavljača antitumorskog lijeka (doksorubicina) na temelju kitozana modificiranog terapeutskim ionima: bakrom, cinkom, borom te fosfatima. Svestranost kitozana kao materijala sustavno smo istražili u našim prijašnjim istraživanjima pri čemu smo dokazali pozitivan učinak na razvoj matičnih stanica u novo koštano tkivo. Predloženo istraživanje je logičan slijed funkcionalizacije biokompatibilnog materijala kao nosača antitumorskog lijeka za ciljano liječenje osteosarkoma. Glavno istraživanje usmjerit će se prema: 1) razvoju pametnog dostavljača lijeka u obliku mikrosfera; 2) razvoju visokoporoznih okosnica kao nosača lijeka i terapeutika za obnovu tkiva; 3) modifikaciji materijala kalcijevim fosfatima za veću djelotvornost antitumorskog lijeka; 4) in vitro biološkoj validaciji materijala s ciljem utvrđivanja njihovog učinka. Očekuje se da će kombinacija antitumorskog lijeka i iona poput bakra, cinka i fosfata djelovati sinergijski na suzbijanje rasta tumorskih stanica te povećanje djelotvornosti lijeka bez utjecaja na zdravo tkivo. Također, očekuje se da će nosač modificiran borom osigurati dvostruko djelovanje: antitumorsko i terapeutsko, odnosno da će poticati vaskularizaciju i rast novog tkiva u koštanim defektima nastalim zbog bolesti. ]]></summary_hr><summary_en><![CDATA[The extensive development of materials as potential drug delivery systems has emerged from the need for less invasive treatment of malignant diseases. The chemotherapy is commonly used method for treating the osteosarcoma, type of a bone tumour that affects children and young adults. The standard procedures are based on intravenous or oral administration of antitumor drug that inevitably affects the whole body before reaching the infected tissue. Consequently, antitumor drug also interacts with healthy organs and tissues increasing the risk of toxicity and adverse drug effects. Arising new strategy for improved treatment is the encapsulation of drug within adequate carrier for controlled release under specific stimulus. This project brings forth the development of smart antitumor drug carriers based on chitosan modified with therapeutic ions: copper, zinc, boron and phosphate ions. In our previous studies, we have proved the versatility of chitosan-based materials as scaffolds that significantly support bone formation from stem cells culture. The proposed investigation is a logical continuation on the improvement of functionality of biocompatible materials in form of delivery carriers for targeted osteosarcoma treatment. The main research focuses on: 1) smart drug delivery systems as microspheres suitable for injection; 2) highly porous scaffolds as drug and therapeutic carriers for tissue regeneration; 3) materials modification by calcium phosphates to enhance the antitumor efficiency; 4) in vitro biological validation of prepared materials on healthy and tumour cells. We expect the synergic activity of antitumor drug (doxorubicin) and copper, zinc and phosphate ions in suppressing the grow th of osteosarcoma cells, as well as improvedefficacy without affecting the surrounding healthy tissue. Furthermore, we expect dual functionality, antitumor and therapeutic, of boron modified scaffolds in a way of inducing the vascularisation and neotissue growth. ]]></summary_en></project><project>
<id>14638</id><title_hr><![CDATA[Istraživanje efikasnijeg i ekološki prihvatljivijeg izgaranja u Ottovim motorima s pretkomorom]]></title_hr><title_en><![CDATA[]]></title_en><user_id>13468</user_id><user_firstLast_name>Momir Sjerić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-5020</code><acronim><![CDATA[EF-PRECOM]]></acronim><duration>14.02.2022 - 13.02.2026</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, </scie_field_hr><scie_field_en>Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>865297</team_members_id><team_members_names><![CDATA[ Doktorand: Sara Ugrinić ]]></team_members_names><keywords_hr><![CDATA[pretkomora, izgaranje, učinkovitost, emisije, motor s unutarnjim izgaranjem]]></keywords_hr><keywords_en><![CDATA[pre-chamber, combustion, efficiency, emissions, internal combustion engine]]></keywords_en><summary_hr><![CDATA[Porast ekološke svijesti posljednjih godina doveo je do značajnog povećanja aktivnosti usmjerenih k smanjenju štetnog utjecaja sektora transporta, kao jednog od najvećih zagađivača, na okoliš. Električna vozila se zbog izazova s kojima se trenutno suočavaju mogu smatrati tek dugoročnim rješenjem dok, s obzirom na sve izraženije posljedice globalnog onečišćenja, postoji potreba za rješenjima koja će barem djelomično ublažiti štetne učinke, a mogu se primijeniti u mnogo kraćem vremenskom okviru. Posljednja istraživanja ukazuju kako Ottovi motori s pretkomorom predstavljaju jednu od ključnih tehnologija u ostvarivanju tih ciljeva. Ipak, dosadašnja istraživanja još uvijek nisu u potpunosti odgovorila na sve izazove za masovnu primjenu ove tehnologije u cestovnim vozilima. Iz pregleda literature identificirana su glavna područja od interesa, u skladu s čime su formirani ciljevi istraživanja. Za pogon benzinom ispitat će se utjecaj volumena i geometrije pretkomore uz zadržavanje konstantne energije goriva u pretkomori te istražiti mogućnost primjene naprednog načina izgaranja (PCHCCI) za poboljšanje rada motora. Za pogon prirodnim plinom ispitat će se primjena i utjecaj povrata ispušnih plinova te različite strategije ispiranja pretkomore što se pokazalo kao jedna od značajnijih problematika u Ottovim motorima s pretkomorom. Prije navedenih ispitivanja modificirati će se i unaprijediti trenutni eksperimentalni postav kako bi se omogućio rad motora s pretkomorom te sva potrebna mjerenja. Glavna svrha ovog istraživanja je temeljitim eksperimentalnim ispitivanjima potpomognutim naprednim numeričkim simulacijama i proračunima, a usmjerenim na dosad neodgovorena pitanja i izazove, dati znanstveni doprinos u istraživanju efikasnijeg i ekološki prihvatljivijeg načina izgaranja u Ottovim motorima te postići dodatni iskorak u pronalasku rješenja za smanjenje globalnog onečišćenja na dobrobit okoliša i cjelokupnog čovječanstva.]]></summary_hr><summary_en><![CDATA[Increased environmental awareness in recent years has led to a significant increase in the activities aimed at reducing the negative impact of the transport sector, as one of the largest polluters, on the environment. Electric vehicles, because of the challenges they currently face, can be considered only as a long-term solution while, given the pronounced effects of global pollution, there is a need for solutions that will at least partially mitigate harmful effects in a much shorter time frame. Recent research indicates that pre-chamber (PC) SI engines represent one of the key technologies in achieving those goals. However, investigations have not yet fully responded to all the challenges for mass application of this technology in road vehicles. From the literature review the main areas of interest are identified, in accordance with which the research objectives were formed. For operation with gasoline the influence of volume and geometry of the PC with constant energy of the fuel in the PC will be examined and the possibility of applying advanced combustion mode (PCHCCI) to improve the operation of the engine will be explored. For operation with natural gas the application and impact of EGR will be examined, as well as different strategies for PC scavenging, which proved to be one of the most important topics in such engines. Prior to the above tests it is necessary to modify and improve the current experimental set-up in order to enable the operation of the engine with PC, as well as all the necessary measurements. The main purpose of this research is to give a scientific contribution in the research of more efficient and environment-friendly combustion by thorough experimental studies, assisted by advanced numerical simulations and calculations directed to unanswered questions and challenges, thus achieving an additional step forward in finding solutions to reduce global pollution for the environment and to improve human life.]]></summary_en></project><project>
<id>14639</id><title_hr><![CDATA[Koncept nepomičnog pola u numeričkom modeliranju Cosseratovog kontinuuma]]></title_hr><title_en><![CDATA[]]></title_en><user_id>906</user_id><user_firstLast_name>Leo Škec</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-6065</code><acronim><![CDATA[FIMCOS]]></acronim><duration>03.11.2022 - 02.11.2026</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Građevinarstvo, </scie_field_hr><scie_field_en>Civil engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Građevinski fakultet u Rijeci]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Civil Engineering]]></institution_en><team_members_id>866591</team_members_id><team_members_names><![CDATA[ Doktorand: Damjan Jurković Jurković ]]></team_members_names><keywords_hr><![CDATA[Cosseratov kontinuum, opis metodom nepomičnoga pola, metoda konačnih elemenata, objektivnost, konzervativna integracija, identifikacija parametara]]></keywords_hr><keywords_en><![CDATA[Cosserats&#39; continuum, fixed-pole description, finite-element method, objectivity, conservative integration, parameter identification]]></keywords_en><summary_hr><![CDATA[U ovome projektnom prijedlogu razmatra se alternativna teorija kontinuuma poznata pod nazivom Cosseratova ili mikropolarna teorija. Predlaže se provedba detaljnije analize u okviru  takozvane metode nepomičnog pola s ciljem razvoja točnih i djelotvornih konačnih elemenata za linearnu i nelinearnu statičku i dinamičku analizu.Elementi će biti razvijeni slijedom niza istraživačkih ciljeva koji se sastoje od (O1) linearne statičke analize, (O2) nelinearne statičke analize, (O3) dinamičke analize i (O4) identifikacije parametara. Na taj način, putem ciljeva O1-O3 razvijeni elementi će tvoriti simulacijski alat sami za sebe, dok će putem cilja O4 stvoriti neophodni preduvjet za robusnu i pouzdanu proceduru potrebnu za identifikaciju materijalnih parametara iz eksperimentalnih mjerenja. Konačni elementi će biti provjereni putem niza standardnih testnih primjera, a par eksperimentalnih postava bit će projektiran da zaključi cilj O4. Ciljevi će biti dosegnuti kroz niz istraživačkih, edukacijskih i upravljačkih aktivnosti koje će voditi članovi projektne grupe i koji će se bazirati na ranijim dostignućima grupe u razvoju konačnih elemenata uključujući vezanu interpolaciju, objektivnu interpolaciju ovisnu o konfiguraciji, algoritme za vremensku integraciju, Cosseratovu elastičnost, metodu nepomičnog pola u nelinearnim gredama i iskustvo u provedbi beskontanog mjerenja. Konačni elementi će biti razvijeni unutar programa za analizu metodom konačnih elemenata FEAP.S projektnim rezultatima upoznat ćemo eksperte i širu javnost putem raznih diseminacijskih kanala, uključujući objave u znanstvenim časopisima najviše kategorije u području računske mehanike, predstavljanja na uglednim specijaliziranim konferencijama, kao i predavanja s ciljem populariziranja projektnoga istraživanja i znanosti općenito.]]></summary_hr><summary_en><![CDATA[An alternative continuum theory called Cosserats’ or micropolar theory is considered within this proposal and a case is made for its more thorough analysis within the framework of the so-called fixed-pole description with the aim of providing accurate and efficient finite elements for linear and non-linear static and dynamic analysis. The elements will be developed by pursuing a set of research objectives consisting of (O1) linear static analysis, (O2) non-linear static analysis, (O3) dynamic analysis and (O4) parameter identification. In this way, through objectives O1-O3 the elements developed will be usable as a simulation tool in their own right while in O4 they will make a vital pre-requisite for a robust and reliable procedure needed for identification of material parameters from experimental measurements. The finite elements will be tested against a number of bench-mark problems, while a couple of experimental setups will be designed to complete O4.The objectives will be reached through a series of research, training and management activities led by the members of the project team and built on previous achievements of the team in finite-element design involving linked interpolation, objective configuration-dependent interpolation, time-stepping algorithms, conventional Cosserats&#39; elasticity, fixed-pole approach in geometrically exact beams as well as experience in performing contactless measurements. The finite elements will be developed within the finite-element-analysis programme FEAP.The project results will be communicated to the professionals and general public through a variety of dissemination channels involving publications in the scientific journals of the highest rank within the area of computational mechanics, presentations at highly reputable thematic conferences, and lectures aimed at popularising the project research and science in general.]]></summary_en></project><project>
<id>14640</id><title_hr><![CDATA[Plazmoni i eksiton-polaritoni u kvazi-2D kristalima]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4933</user_id><user_firstLast_name>Vito Despoja</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-5657</code><acronim><![CDATA[2DPlasEx]]></acronim><duration>15.10.2021 - 11.11.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut za fiziku]]></institution_hr><institution_en><![CDATA[Institute of Physics in Zagreb]]></institution_en><team_members_id>864851</team_members_id><team_members_names><![CDATA[ Doktorand: Josip Jakovac ]]></team_members_names><keywords_hr><![CDATA[plazmoni, eksitoni, fononi, polaritoni, 2D kristali, spektroskopija  ]]></keywords_hr><keywords_en><![CDATA[plasmons, excitons, phonons, polaritons, 2D crystals, spectroscopy ]]></keywords_en><summary_hr><![CDATA[Cilj ovog projekta je istražiti elektromagnetske modove u vodljivim i poluvodičkim 2D kristalima poput grafena ili heksagonalnog borovog-nitrida (hBN) dopiranih atomima alkalijskih metala (Li, K, Cs)  ili u dihalkogenidima prijelaznih metala (TMDs). Naglasak ce biti na izučavanju  inteziteta i disperzijskih relacija kolektivnih elektromagnetskih modova, tj. plazmon-polaritona i eksiton-polaritona u 2D kristalima.  Istraživanje će se provesti u okviru mnogočestične perurbacijske teorije, točnije riješavati će se Bethe-Salpeterova jednadžba u kojoj će se kao baza koristiti DFT osnovno stanje dobiveno pomoću programskog paketa QuantumEspresso. U mnogočestični formalizam biti će uključeni efekti retardacije, interakcija (raspad i hibridizacija) plazmon-polaritona sa fononima te utjecaj metalnog ili poluvodičkog substrata na elektromagnetska svojstva 2D kristala. Ovo  metodu  čini superiornijom u odnosu na dosad korištene metode  i omogućiti će otkrivanje novih još neistraženih fenomena. Razumijevanje novih fenomena moglo bi pomoći u proizvodnji nove klase optoelektroničkih uređaja kao što su 2D fotodetektori, fotodiode ili fotonaponski uređaji ili plinski, kemijski i organski detektori. Na poslijetku, razumjevanje interakcije plazmon-polaritona sa LO fonona u dopiranim 2D kristalima moglo bi razjasniti granice primjenjivosti plazmon-polaritona u telekomunikacijama.      ]]></summary_hr><summary_en><![CDATA[The aim of this project is to investigate electromagnetic modes in conductive and semiconductive 2D crystals such as graphene or hexagonal boron-nitride (hBN) dopedby alkali metals (Li, K, Cs) or in transition-metal-dichalcogenide monolayers (TMDs). The emphasis will be on the study of the intensity and dispersion relations of the collectiveelectromagnetic modes, i.e. plasmon-polaritons and exciton-polaritons in 2D crystals. The investigation will be provided in the framework of the many-body perturbationtheory, i.e. by solving the Bethe-Salpeter equation in which enters the DFT ground state base-set obtained using the software package QuantumEspresso. Used many-body formalism include the effects of retardation, interaction (decay and hybridization) of plasmon-polaritons with phonons and the influence of a metallic or semiconductive  substrate on electromagnetic properties in 2D crystals. This makes the method superior to the methods used so far and will allow exploration of new phenomena. Understanding new phenomena could help in fabrication of a new class of optoelectronic devices such as 2D photodetectors, photodiodes or photovoltaic devices or gas, chemical and organic detectors. Finally, understanding the interaction of plasmon-polaritons with LO phonons in doped 2D crystals could clarify the applicability limits of plasmon-polaritons in telecommunications.]]></summary_en></project><project>
<id>14642</id><title_hr><![CDATA[Distribucijska elektroenergetska mreža s velikim udjelom aktivnih kupaca]]></title_hr><title_en><![CDATA[]]></title_en><user_id>25526</user_id><user_firstLast_name>Danijel Topić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-1257</code><acronim><![CDATA[ProPowerNet]]></acronim><duration>03.11.2021 - 02.11.2025</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera Osijek, Fakultet elektrotehnike, računarstva i informacijskih tehnologija Osijek]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Electrical Engineering, Computer Science and Information Technology Osijek]]></institution_en><team_members_id>865198</team_members_id><team_members_names><![CDATA[ Doktorand: Marina Dubravac ]]></team_members_names><keywords_hr><![CDATA[aktivni kupac, distribucijska elektroenergetska mreža, kvaliteta električne energije, tržište električne energije, stabilnost sustava ]]></keywords_hr><keywords_en><![CDATA[prosumer, distribution power network, power quality, electricity market, system stability]]></keywords_en><summary_hr><![CDATA[Proizvodnja električne energije iz većine elektrana na obnovljive izvore energije (OIE) uglavnom je promjenjiva i nepredvidiva što uzrokuje poteškoće u planiranju i vođenju elektroenergetske mreže te se masovnom integracijom takvih postrojenja taj učinak povećava. Dosadašnji pasivni kupci električne energije integracijom elektrana na OIE u njihovom vlasništvu postaju kupci s vlastitom proizvodnjom, odnosno postaju aktivni kupci. Razvoj sustava upravljanja energijom aktivnih kupaca je multidisciplinarni proces koji podrazumijeva više aspekata promatranja koji se moraju uzeti u obzir. Svrha ovog projekta je uspostavljanje istraživačke grupe koja će proučavati upravljanje pogonom sustava aktivnog kupca i distribucijske mreže s četiri aspekata promatranja: prvi je maksimizacija zarade aktivnog kupca sudjelovanjem na energetskom tržištu i tržištu pomoćnih usluga, drugi je optimizacija pogona same distribucijske mreže s ciljem smanjenja gubitaka i održavanja poželjnih strujno-naponskih prilika u mreži, treći je smanjenje utjecaja na kvalitetu električne energije i četvrti aspekt promatranja je održavanje naponske i frekvencijske stabilnosti mreže u slučaju priključenja većeg broja aktivnih kupaca na distribucijsku mrežu. Ciljevi projekta obuhvaćaju izrađene simulacijske modele za analizu međudjelovanja distribucijske mreže i sustava aktivnih kupaca te razvijene optimizacijske algoritme za određivanje optimalnog pogona uređaja aktivnih kupaca i distribucijske mreže za različite aspekte promatranja. Rezultati projekta doprinijeti će mogućnosti velike integracije aktivnih kupaca u distribucijsku mrežu uz očuvanje frekvencijske i naponske stabilnosti sustava te propisane razine kvalitete električne energije. Uz to, omogućit će aktivnim kupcima određivanje plana angažiranja njihovih uređaja s ciljem optimalne zarade na tržištu električne energije te tržištu pomoćnih usluga. ]]></summary_hr><summary_en><![CDATA[Electricity generation from the most of renewable energy sources (RES) based power plants is generally variable and unpredictable which causes difficulties in the electricity grid planning and operation, while this effect magnifies even more by the massive integration of such power plants. Previous passive consumers by integration of RES based power plants in their ownership are becoming consumers with their own production, or so-called prosumers. The development of a prosumer energy management system is a multidisciplinary process that involves multiple aspects that must be considered. The purpose of this project is to establish a research group to study the operation of a prosumer system and distribution network within four aspects of observation: first is maximizing the prosumers profit by participating on the electricity and ancillary services markets, second is the optimization of the distribution network operation with objectives of power losses minimization and maintaining the desired loading and voltage levels in the network, third is to reduce the impact on the power quality and the fourth aspect is to maintain the voltage and frequency stability of the network when large number of prosumers are connected to the distribution network. The objectives of the project include developed simulation models for analyzing the interactions of the distribution network and the prosumer system, as well as the developed optimization algorithms for determining the optimum drive of the prosumer devices and distribution network for various aspects of observation. The results of the project will contribute to the possibility of large-scale integration of prosumers in the distribution network while maintaining the frequency and voltage stability of the system and the prescribed level of power quality. In addition, it will enable prosumers to determine the operation plan for their devices in order to optimize their earnings in the electricity and ancillary services markets.]]></summary_en></project><project>
<id>14643</id><title_hr><![CDATA[Livadni procjepak (Chouardia litardierei, Hyacinthaceae) kao istraživački sustav ekološke divergencije]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5829</user_id><user_firstLast_name>Ivan Radosavljević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-5822</code><acronim><![CDATA[AMS-EcolDiv]]></acronim><duration>15.12.2021 - 14.12.2025</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>865214</team_members_id><team_members_names><![CDATA[ Doktorand: Sara Laura Šarančić ]]></team_members_names><keywords_hr><![CDATA[ekotip, ekološka divergencija, lokalna adaptacija, specijacija, reproduktivna izolacija, vrtni pokus, GWAS, GBS, epiGBS]]></keywords_hr><keywords_en><![CDATA[ecotype, ecological divergence, local adaptation, speciation, reproductive isolation, common garden experiment, GWAS, GBS, epiGBS]]></keywords_en><summary_hr><![CDATA[U populacijama koje je inicijalno nemoguće razlikovati bilo genetski ili fenotipski, nakupljanje genetskih razlika može dovesti do razvoja reproduktivne izolacije koja onemogućava daljnji protok gena između promatranih skupina. Kao posljedica prilagodbe organizama na specifične okolišne uvjete mogu se pojaviti novi ekotipovi, tj. skupine morfoloških i genetski diferenciranih jedinki. Istraživanje složenih interakcija između okoliša, fenotipa, epigenotipa i genotipa na grupi blisko srodnih jedinki koje su se prilagodile iznimno kontrastnim stanišnim uvjetima, stekli bismo dragocjena saznanja o mehanizmima koji su temelj jednog od osnovnih procesa evolucije: specijacije. S ciljem stjecanja što više spoznaja o ovoj problematici, livadni procjepak (Chouardia litardierei, Hyacinthaceae) izabran je kao istraživački sustav. Ovu specifičnu vrstu nalazimo u ekološki iznimno  kontrastnim okruženjima, od slanih obalnih staništa, preko vlažnih planinskih travnjaka, do visokoplaninskih, izuzetno suhih pukotina stijena na nadmorskim visinama iznad 2000 m. Planirano istraživanje provesti će se primjenom najmodernijih metoda pri čemu će se objasniti različiti aspekti procesa lokalne prilagodbe i ekološke divergencije. Koji geni se nalaze u osnovi prilagodbe organizama na lokalno specifične uvjete? Kako su strukturne razlike raspoređene unutar genoma različitih ekotipova i koja je njihova uloga u procesima lokalne prilagodbe i specijacije? Koje je značenje epigenetskih promjena u tom procesu? Koji mehanizmi se nalaze u osnovi razvoja i održavanja reproduktivnih barijera? Ovo su glavna pitanja na koja će se tražiti odgovori ovim znanstvenim projektom. Slijedeći najviše trenutne standarda unutar discipline, cjelokupno istraživanje bazirati će se na de-novo sastavljenom genomskom sklopu. Primjenom različitih, no iznimno kompatibilnih eksperimentalnih i analitičkih pristupa, dobiti će se iscrpan uvid u složeni proces lokalne adaptacije i ekološke divergencije odabrane biljne svojte.]]></summary_hr><summary_en><![CDATA[In populations that initially could not be distinguished from each other, either genetically or phenotypically, accumulation of genetic differences can gradually lead to development of reproduction isolation that disables any further gene flow between diverged groups. As a consequence of organism adaptation to specific environmental conditions, new ecotypes i.e. groups of morphologically and genetically divergent individuals, can emerge. By exploring complex interactions among environment, phenotype, epigenotype and genotype in a group of closely related organisms that have adopted to highly contrasting environments, we could gain a valuable knowledge of the mechanisms underlying one of the evolution’s fundamental process: the speciation. With intention of gathering as much information as possible on this subject, Amethyst Meadow Squill (Chouardia litardierei, Hyacinthaceae) was chosen as a study system. This exceptional monocot species inhabits highly contrasting environments, from saline habitats of seashores, across wet mountain grasslands, to subalpine, extremely dry rock crevices above 2000 m a.s.l. By using different state-of-the art approaches, different aspects of local adaptation and divergence process will be studied and explained. Which genes underlie organisms’ adaptation to contrasting environment? How are structural differences distributed across genomes of diverging organisms and what is their role in the local adaptation and speciation processes? What is the role of epigenetics in the process? Which mechanisms underlie development and maintenance of reproductive barriers? These are the major questions answers to which will be sought by this project. To follow the highest standards in the field, entire research will be based on draft genome assembly. By implementing different, yet highly compatible experimental and analytical approaches, thorough insight of the adaptive radiation process will be gained.  ]]></summary_en></project><project>
<id>14644</id><title_hr><![CDATA[Razvoj naprednih analitičkih metoda za lijekove i biološki aktivne tvari u liječenju upalnih bolesti crijeva]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1301</user_id><user_firstLast_name>Ana Mornar Turk</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-7922</code><acronim><![CDATA[IBDAnalytics]]></acronim><duration>03.11.2021 - 02.11.2025</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Farmacija, </scie_field_hr><scie_field_en>Pharmaceutical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Farmaceutsko-biokemijski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Pharmacy and Biochemistry]]></institution_en><team_members_id>865187</team_members_id><team_members_names><![CDATA[ Doktorand: Jelena Kovačić ]]></team_members_names><keywords_hr><![CDATA[upalne bolesti crijeva, kromatografija, masena spektrometrija, tehnike pripreme uzoraka, kontrola kvalitete lijekova, dodaci prehrani, biološki lijeko]]></keywords_hr><keywords_en><![CDATA[inflammatory bowel disease, chromatography, mass spectrometry, sample preparation, ADME, quality control, dietary supplements, biopharmaceuticals]]></keywords_en><summary_hr><![CDATA[Upalne bolesti crijeva (UBC) spadaju u skupinu upalnih bolesti kod kojih upalni proces zahvaća područje tankog i debelog crijeva. Odabir farmakoterapije ovisno o proširenosti  i smještenosti bolesti,  neželjenim popratnim pojavama i cijeni. Budući da smanjuju potrebu za koritikosteroidima, imunomodulatori su najčešće propisivani lijekovi u liječenju UBC. Liječenje s monoklonskim protutijelima omogućava liječenje visoko specifičnim i neposrednim mehanizmom djelovanja, ali visoka cijena utječe na učestalost primjene ove skupine lijekova.Budući da upalni procesi u crijevima narušavaju resorpciju vitamina i minerala, pacijentima se preporuča njihova suplementacija tijekom farmakoterapije. Štoviše, nedostatak folne kiseline povećava rizik razvoja tumora kod pacijenata oboljelih od UBC.Velik broj pacijenata smatra dodatke prehrani koje sadrže biljne ekstrakte sigurnim i prirodnim načinom liječenja. Stoga, velik broj pacijenata oboljelih od UBC koriste dodatke prehrani koji sadrže indijski tamjanovac, justiciju i kurkumu.Glavni cilj predloženog istraživanja je razviti nove instrumentalne analitičke metode za kontrolu kvalitete lijekova i dodataka prehrani koji se koriste u liječenju UBC.Kako bi se poboljšala suradljivost pacijenata predložit će se nove fiksne kombinacije imunosupresiva i folne kiseline. Razvit će se metode za ispitivanje farmakokinetike, kontrole kvalitete i terapeutskog praćenja koncentracije lijekova. Razvit će se i analitičke metode za određivanje aktivnih i toksičnih tvari u biljnim dodacima prehrani te će se metode primijeniti za procjenu kvalitete dodataka prehrani na hrvatskom tržištu. Konačno, razvit će se 2D-SE-RP-DAD tehnika za određivanje monoklonskih protutijela i njihovih onečišćenja u biološkim i biosličnim lijekovima.]]></summary_hr><summary_en><![CDATA[Inflammatory bowel disease (IBD) is a group of inflammatory conditions of the colon and small intestine. In IBD, treatment decision is dependent on the stage of the disease, laboratory findings and endoscopic examination. Choice of pharmacotherapy depends largely on the severity of disease, location, side effects and adverse events, as well as cost. Immunosuppressants are the most prescribed drug class in IBD treatment as steroid-sparing therapy. The treatment of IBD with monoclonal antibodies presents high specificity and directed mechanism of action, but the high cost still represents a barrier to be overcome. As the inflammatory process along the digestive tract disrupts resorption of vitamins and minerals, their additional supplementation is recommended with pharmacotherapy therapy. Moreover, low folate intake has been associated with tumor growth in IBD. The majority of the patients consider herbal dietary supplements are safe and natural way of healing. Many patients with IBD take supplements such as Indian frankincense, Justicia and Turmeric. The main objective of the proposed research is to develop new instrumental analytical methods that could be applied in quality control of medicinal products and dietary supplements used in treatment of IBD. A new fix-dose combination of two drugs an immunosuppressant and folic acid to improve patient&#39;s adherence to their prescribed treatment will be proposed. Methods for investigation of pharmacokinetic behaviour, quality control and therapeutic drug monitoring will be developed. Analytical methods for determination of active and toxic compounds of herbal dietary supplements will be developed. The proposed methods will be applied for evaluation of quality assurance for dietary supplements in Croatian marketplace. Finally, an advanced 2D-SE-RP-HPLC/DAD technique will be proposed and applied for determination of monoclonal antibodies and their impurities in biologic drugs and biosimilars.]]></summary_en></project><project>
<id>14645</id><title_hr><![CDATA[Nova bioanalitička rješenja za personalizaciju terapije raka dojke]]></title_hr><title_en><![CDATA[]]></title_en><user_id>13100</user_id><user_firstLast_name>Miranda Sertić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-4595</code><acronim><![CDATA[OncoBioAnalytics]]></acronim><duration>01.12.2021 - 01.12.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Farmacija, </scie_field_hr><scie_field_en>Pharmaceutical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Farmaceutsko-biokemijski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Pharmacy and Biochemistry]]></institution_en><team_members_id>865246</team_members_id><team_members_names><![CDATA[ Doktorand: Zvonimir Mlinarić ]]></team_members_names><keywords_hr><![CDATA[karcinom dojke, terapijsko praćenje lijeka, farmakokinetika, tekućinska kromatografija spregnuta s masenom spektrometrijom, kapilarna elektroforeza]]></keywords_hr><keywords_en><![CDATA[breast cancer, therapeutic drug monitoring, pharmacokinetics, liquid chromatography coupled to mass spectrometry, capillary electrophoresis]]></keywords_en><summary_hr><![CDATA[Rak dojke je najčešći zloćudni tumor u žena, od kojeg će oboljeti svaka osma žena. Gotovo 80% slučajeva raka dojke pozitivno je na hormonske receptore (HR+) i liječi se endokrinom terapijom. Nedavno je uvedena kombinacija endokrine (inhibitori aromataze anastrozol ili letrozol; antiestrogen fulvestrant) i ciljane terapije (inhibitori CDK4/6 palbociclib i ribociclib) za liječenje metastatskog raka dojke podtipa HR+, HER2- (receptor humanog epidermalnog faktora rasta 2).Kako bi se postigli bolji ishodi terapije i smanjile neželjene nuspojave, potreban je personalizirani pristup liječenju u svakodnevnoj kliničkoj praksi, čemu mogu značajno pridonijeti pouzdane i točne analitičke metode za terapijsko praćenje (TDM) onkoloških lijekova.Cilj ovog istraživanja je predložiti nove, osjetljive i selektivne bioanalitičke metode koji će poslužiti kao platforma za personalizirani pristup liječenju raka dojke. Naglasak će biti na novoodobrenim lijekovima, palbociklibu i ribociklibu, koji se primjenjuju zajedno s inhibitorima aromataze ili s fulvestrantom. Također će se provesti farmakokinetička i metabolička ispitivanja.Predložene nove analitičke metode koristit će se za praćenje koncentracije odabranih lijekova u plazmi. Bit će razvijene sofisticirane metode tekućinske kromatografije povezane s masenom spektrometrijom (HPLC-MS). Kao alternativa skupoj i složenoj HPLC-MS tehnici bit će razvijena robustna i potpuno automatizirana tehnika kapilarne elektroforeze (CE). CE ima veliki potencijal za primjenu u kliničkoj praksi zbog jednostavnosti i automatiziranosti, nakon uspostave validiranih protokola. Rezultati istraživanja će omogućiti optimalno terapijsko doziranje i povećati učinkovitost terapije, izbjegavajući toksičnost, nuspojave ovisne o koncentraciji ili izostanak željenog terapijskog učinka. Stoga će ovaj projekt doprinijeti implementaciji TDM-a za ciljanu terapiju raka dojke u sklopu standardne zdravstvene zaštite.]]></summary_hr><summary_en><![CDATA[Breast cancer is the most common malignant tumor in women with a one in eight prevalence.  Almost 80% of breast cancers are hormone receptor positive (HR+) and treated with endocrine therapy. Recently, a combination of endocrine (aromatase inhibitors anastrozole or letrozole; antiestrogen fulvestrant) and targeted therapy (CDK4/6 inhibitors palbociclib and ribociclib) has been introduced for the treatment of metastatic breast cancer subtype HR+, HER2- (human epidermal growth factor receptor 2). To achieve better therapy outcomes and reduce adverse drug events, a personalized approach to breast cancer treatment in routine clinical practice is needed. Reliable and accurate analytical methods for therapeutic drug monitoring (TDM) of oncology drugs can significantly contribute to this goal. The aim of this study is to propose new, reliable, sensitive and selective bioanalytical tools that will serve as a platform for a personalized approach to breast cancer treatment. Emphasis will be given to newly approved palbociclib and ribociclib, which are co-administered with aromatase inhibitors or fulvestrant. Pharmacokinetic and metabolic studies will also be conducted. Proposed new analytical methods will be used to monitor plasma concentrations of selected drugs. Highly sophisticated liquid chromatography coupled to mass spectrometry methods (HPLC-MS) will be developed. As an alternative to expensive and complex HPLC-MS technique, robust and fully automated capillary electrophoresis (CE) technique will be developed. CE has a great potential for translation to clinical setting due to minimal training and supervision required after establishing validated protocols. Research results will enable optimal therapeutic dosing and enhance the effectiveness of anticancer therapy, avoiding toxicity, concentration-dependent side-effects or therapeutic failure. This project will contribute to implementation of TDM for targeted breast cancer therapy as a part of standard health care.]]></summary_en></project><project>
<id>14646</id><title_hr><![CDATA[‘MEDIADELCOM’ - Critical Exploration of Media Related Risks and Opportunities for Deliberative Communication: Development Scenarios of the European Media Landscape’ ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>20470</user_id><user_firstLast_name>Zrinjka Peruško</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-3833</code><acronim><![CDATA[]]></acronim><duration>23.12.2021 - 23.12.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Sociologija, </scie_field_hr><scie_field_en>Sociology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet političkih znanosti]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Political Science]]></institution_en><team_members_id>865262</team_members_id><team_members_names><![CDATA[ Doktorand: Filip Trbojević ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>14647</id><title_hr><![CDATA[Kvantitativna i kvalitativna analiza proteina za potrebe biomedicine i biotehnološke industrije]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3536</user_id><user_firstLast_name>Mario Cindrić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-4493</code><acronim><![CDATA[]]></acronim><duration>06.12.2021 - 05.06.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>865098</team_members_id><team_members_names><![CDATA[ Doktorand: Luka Ozdanovac ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>14648</id><title_hr><![CDATA[Digitalna tehnologija u obitelji: obrasci ponašanja i učinci na razvoj djece]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6384</user_id><user_firstLast_name>Marina Merkaš</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-1523</code><acronim><![CDATA[ D.E.C.I.D.E.]]></acronim><duration>17.11.2021 - 18.05.2026</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Psihologija, </scie_field_hr><scie_field_en>Psychology, </scie_field_en><institution_hr><![CDATA[Hrvatsko katoličko sveučilište, Zagreb]]></institution_hr><institution_en><![CDATA[Catholic University of Croatia]]></institution_en><team_members_id>865188</team_members_id><team_members_names><![CDATA[ Doktorand: Matea Bodrožić Selak ]]></team_members_names><keywords_hr><![CDATA[digitalna tehnologija, obitelj, roditelji, djeca, dobrobit, razvoj]]></keywords_hr><keywords_en><![CDATA[digital technology, family, parents, children, well-being, development]]></keywords_en><summary_hr><![CDATA[Digitalna tehnologija (DT) oblikuje život djece, roditelja i obitelji svakodnevno. Projekt D.E.C.I.D.E. ima za cilj ispitati: a) motivaciju, navike i okolnosti korištenja DT te ometanje tehnologijom (OT) u roditelja, djece i obitelji, b) povezanost korištenja DT te OT u djece, roditelja i obitelji s razvojem i dobrobiti djece i c) OT tijekom interakcija roditelj-dijete te učinke OT na ponašanje djece. Na temelju rezultata dosadašnjih istraživanja, teorijskih objašnjenja učinaka kontekstualnih čimbenika na razvoj djece, obiteljske medijske ekologije, bioekološkog modela ljudskog razvoja, modela različite osjetljivosti na učinke medija, teorija o recipročnim učincima medija te preporuka za buduća istraživanja, postavljen je model mogućih učinaka i procesa djelovanja DT na djecu u obiteljskom kontekstu. Kombinacijom kvalitativne i kvantitativne istraživačke metodologije kroz 4 studije (fokus grupe, longitudinalno istraživanje, dnevničku studiju i opažanje) s djecom od 0 do 13 godina i roditeljima, empirijski se žele provjeriti hipoteze o diferencijalnoj osjetljivosti djece, roditelja i obitelji na učinke DT te OT, kao i postojanje neizravnih procesa djelovanja DT i OT na djecu. Očekuje se potvrda različite osjetljivosti djece, roditelja i obitelji na DT i OT te neizravnih procesa djelovanja DT i OT na razini pojedinca, odnosa i sustava na razvoj i dobrobit djece. Po završetku projekta očekuje se uspostavljena istraživačka grupa, 7 pozitivno recenziranih i/ili prihvaćenih za objavljivanje znanstvenih radova, 15 izlaganja na konferencijama, izrađena 1 disertacija i 3 diplomska rada, održane 2 istraživačke radionice sa stručnjacima iz inozemstva i festival za djecu i obitelji. Projektom se želi stvoriti baza znanja o učincima DT na razvoj djece u obiteljskom kontekstu, koja bi onda poslužila svim akterima dječjeg razvoja za osmišljavanje različitih praktičnih programa utemeljenih na dokazima i usmjerenih umanjivanju negativnih, a poticanju pozitivnih učinaka DT na djecu.]]></summary_hr><summary_en><![CDATA[Digital technology (DT) shapes the lives of children, parents, and families daily. Project D.E.C.I.D.E. aims to examine: a) the motivation, habits, and circumstances of DT use and technology interference (TI) in parents, children, and families, b) the relations of DT use and TI in children, parents, and families with child development and well-being, and c) TI during parent-child interaction and TI effects on the behaviour of children. Based on the results of the previous research, theoretical explanations of the effects of contextual factors on child development, family media ecology, the bioecological model of human development, the differential susceptibility to media effects model, theories about reciprocal effects of media, and recommendations for future research, a model of the possible effects and processes of effects of DT and TI on children in a family context is developed. An empirical examination of proposed hypotheses about the differential sensitivity of children, parents, and families to the effects of DT and TI, and the indirect effects and processes of effects of DT and TI on children is planned using qualitative and quantitative research methodology via 4 studies with children aged 0 to 13 years and parents. The confirmation of different sensitivity of children, parents, and families to DT and TI and the indirect effects of DT and TI on child development and well-being are expected. Expected outcomes upon completion of the project: the established research group, 7 positively reviewed and/or published scientific papers, 15 held presentations, 1 dissertation and 3 graduate theses written, 2 research workshops and a festival for children and families held. The project aims to create a knowledge base on the effects of DT on child development in a family context, that would serve to all actors of child development for designing evidence-based practical programs aimed at reducing the negative and enhancing the positive effects of DT on children.]]></summary_en></project><project>
<id>14650</id><title_hr><![CDATA[Multilinearna i nelinearna harmonijska analiza i primjene]]></title_hr><title_en><![CDATA[]]></title_en><user_id>740</user_id><user_firstLast_name>Vjekoslav Kovač</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-1816</code><acronim><![CDATA[MUNHANAP]]></acronim><duration>20.12.2021 - 19.12.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>865261</team_members_id><team_members_names><![CDATA[ Doktorand: Bruno Predojević ]]></team_members_names><keywords_hr><![CDATA[bilinearna Hilbertova transformacija, multilinearni množitelj, ergodičko usrednjenje, Szemerédijev teorem, nelinearna Fourierova analiza]]></keywords_hr><keywords_en><![CDATA[bilinear Hilbert transform, multilinear multiplier, ergodic average, Szemerédi theorem, nonlinear Fourier analysis]]></keywords_en><summary_hr><![CDATA[Predloženi znanstveni projekt pripada grani harmonijske analize, ali ga se može smatrati interdisciplinarnim unutar polja matematike, u smislu da naša grupa namjerava riješiti nekoliko otvorenih problema iz raznovrsnih matematičkih grana, poput ergodičke teorije, aditivne kombinatorike i same harmonijske/Fourierove analize. Naš pristup će svesti te probleme na odgovarajuće kvantitativne (multilinearne ili nelinearne) ocjene u harmonijskoj analizi, koje ćemo potom dokazati analitičkim tehnikama.Prvi dio našeg projekta proučava ocjene multilinearnih integralnih formi sa zapetljanom strukturom. Ovdje namjeravamo dokazati ocjene za singularne forme pridružene hipergrafovima i pojačati poznate ocjene za multilinearne i simpleks Hilbertove transformacije. U drugom dijelu projekta proučavamo kvantitativnu konvergenciju višestrukih ergodičkih usrednjenja. Glavni ciljevi su nam omeđivanje varijacije po normi tih usrednjenja obzirom na potencije jedne transformacije, odnosno obzirom na nekoliko komutirajućih transformacija te kontrola varijacije po normi/točkama kubičnih ergodičkih usrednjenja. Treći dio bavi se teoremima Szemerédijevog tipa za podskupove euklidskog prostora s pozitivnom gustoćom te jakom verzijom Littlewoodove slutnje, usputno dokazujući odgovarajući invezni teorem. Četvrti dio projekta proučava SU(1,1) model nelinearne Fourierove analize. Karakteriziramo konvergenciju lakunarnih SU(1,1) trigonometrijskih produkata po normi i g.s. te ispitujemo uniformnu ograničenost konstanti u nelinearnoj Hausdorff-Youngovoj nejednakosti.Dakle, cjelokupni smjer našeg istraživanja je jedinstveni spoj tema međusobno povezanih specifičnim tehnikama pristupa. Neka od pitanja na koja namjeravamo dati odgovor već su dosad opsežno popularizirana u postojećoj literaturi i dokazano su teška i zanimljiva.]]></summary_hr><summary_en><![CDATA[The proposed project falls into the realm of harmonic analysis, but it can be regarded as inter-disciplinary within the field of mathematics, in the sense that our group intends to solve several open problems from diverse branches of mathematics, such as ergodic theory, additive combinatorics, and the harmonic/Fourier analysis itself. Our approach will reduce those problems to the appropriate quantitative (multilinear or nonlinear) estimates in harmonic analysis, which will then be established using the analytical techniques.The first part of our project studies estimates for multilinear integral forms with entangled structure. Here we intend to prove estimates for singular forms associated with hypergraphs and improve the current estimates for the multilinear and simplex Hilbert transforms. In the second part of the project we investigate quantitative convergence of multiple ergodic averages. The main objectives are to bound the norm-variation of those averages with respect to powers of a single transformation or with respect to several commuting transformations, and to control the norm/pointwise-variation of cubic ergodic averages. The third part deals with the Szemerédi-type theorems for positive density subsets of the Euclidean space and with the strong version of Littlewood&#39;s conjecture, proving the corresponding inverse theorem along the way. The fourth part of the project studies the SU(1,1) model of the nonlinear Fourier analysis. We characterize the norm convergence and the a.e. convergence of the lacunary SU(1,1) trigonometric products and we investigate uniform boundedness of the constants in the nonlinear Hausdorff-Young inequality.Therefore, our research theme is a unique blend of the topics related by the specific techniques of approach. Some of the questions we intend to answer have already been popularized in the existing literature and they have proven to be difficult and interesting.]]></summary_en></project><project>
<id>14651</id><title_hr><![CDATA[Notch signaling in osteoclast progenitors induced by rheumatoid arthritis]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3075</user_id><user_firstLast_name>Danka Grčević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-6365</code><acronim><![CDATA[NORA]]></acronim><duration>15.05.2022 - 14.05.2026</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>865435</team_members_id><team_members_names><![CDATA[ Doktorand: Sara Aničić ]]></team_members_names><keywords_hr><![CDATA[osteoclasts, arthritis, Notch, inflammation, progenitors, differentiation, cytokines, chemokines]]></keywords_hr><keywords_en><![CDATA[osteoklasti, artritis, Notch, upala, progenitori, diferencijacija, citokini, kemokini]]></keywords_en><summary_hr><![CDATA[Reumatoidni artritis karakteriziran je kroničnim upalnim odgovorom uz periartikularni i sustavni gubitak kosti uzrokovan pojačanom koštanom razgradnjom osteoklastima. S incidencijom od oko 1%, predstavlja značajan javnozdravstveni problem i pridonosi smanjenju kvalitete života. Osteokasti su velike multinuklearne stanice koje razgrađuju kost , a nastaju iz hematopoetskih stanica monocitno/makrofagne loze. Novije studije upućuju na moguću ulogu Notch signalnog puta u proliferaciji, diferencijaciji i migraciji stanica osteolastne loze. Međutim, točan mehanizam kako Notch signalni put djeluje u kontekstu artritisa nije poznat. Glavni cilj predloženog projekta je definirati ulogu Noch signalnog puta u proliferaciji, migraciji i diferencijaciji osteoklastnih progenitora u artritisu te testirati ima li manipulacija Notch signalnog puta učinak na aktivnost osteoklastnih progenitora i osteoresortivni potencijal.Korištenjem modela mišjeg artritisa izazvanog kolagenom (CIA) i uzoraka bolesnika s artritisom, cilj nam je razumjeti izražaj komponenti Notch sustava u pojedinim fazama tijekom diferencijacije osteoklasta i promjene izazvane artritisom, te učinke Notch-liganda na aktivnost osteoklastnih progenitora. Nadalje, planiramo testirati učinak inhibicije Notcha na proliferaciju, migraciju i diferencijaciju osteoklastnih progenitora in vitro. Kao in vivo model, primijenit ćemo neutralizacijska protutijela protiv Notcha i CreERT2 transgenične miševe u kojim će Notch signal biti inhibiran selektivno u osteoklastnim progenitorima koji izražavaju CX3CR1.Mišji CIA-model omogućit će praćenje i modulaciju razvoja bolesti uzrokovane pojačanom koštanom resorpcijom in vivo, dok će analiza ljudskih uzoraka omogućiti translaciju u kliničke uvjete. Karakterizacija Noch-signalnog puta u osteoklastnim progenitorima potaknutim artritisom pruža mogućnost razvoja terapijskih pristupa kojima će se kontrolirati njihova aktivnost, smanjujući time koštanu destrukciju uzorkovanu artritisom. ]]></summary_hr><summary_en><![CDATA[Rheumatoid arthritis (RA) is characterized by chronic inflammatory response as well as periarticular and generalized bone loss due to enhanced bone resorption by osteoclasts. With a prevalence of around 1%, it is an important contributor to public health burden and lower quality of life. Osteoclasts are large multinucleated bone-resorbing cells arising from monocyte/macrophage hematopoietic lineage. Recent evidences suggest the possible role of Notch signaling pathway in proliferation, differentiation and migration of osteoclast lineage cells. However, exact mechanism of how the Notch signaling works in the context of arthritis is largely unclear.The main goal of project proposal is to define the role of Notch signaling in osteoclast progenitor (OCP) proliferation, migration and differentiation in arthritis and to test if manipulation of Notch signaling has the effect on OCP activity and bone resorbing potential. Using the approach of mouse model of collagen-induced arthritis (CIA) and samples from arthritic patients, we aim to understand the stage specific expression of Notch system components during osteoclast differentiation and changes associated with arthritis, as well as the effects of Notch ligands on OCP activity. Furthermore, we plan to test the effect of Notch inhibition on OCP proliferation, migration and differentiation in vitro. As the in vivo model, we will utilize Notch inhibition by neutralizing antibodies and CreERT2 transgenic mouse model in which Notch signal is inhibited by tamoxifen injection selectively in CX3CR1-expressing OCPs.The mouse CIA model will enable us to monitor and modulate disease progression in the context of increased osteoresortion in vivo whereas the analysis of human samples will allow for the translation to the clinical settings. Characterization of Notch signaling in OCPs induced by arthritis could offer the potential to design therapeutic approaches to control their activity thus limiting bone destruction in arthritis.]]></summary_en></project><project>
<id>14652</id><title_hr><![CDATA[Klimatske promjene i varijabilnost u Hrvatskoj – od globalnih utjecaja do lokalnih zelenih rješenja]]></title_hr><title_en><![CDATA[]]></title_en><user_id>2650</user_id><user_firstLast_name>Ivana Herceg Bulić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-9704</code><acronim><![CDATA[CroClimGoGreen]]></acronim><duration>01.02.2022 - 31.01.2026</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Geofizika, </scie_field_hr><scie_field_en>Geophysics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>862800</team_members_id><team_members_names><![CDATA[ Doktorand: Marijana Boras ]]></team_members_names><keywords_hr><![CDATA[urbani toplinski otok, klimatsko modeliranje, mjere ublažavanja, zelena i plava infrastruktura, Hrvatska]]></keywords_hr><keywords_en><![CDATA[urban heat island, climate modelling, mitigation measures, green and blue infrastructure, Croatia]]></keywords_en><summary_hr><![CDATA[Urbani razvoj bitno mijenja obilježja Zemljine površine i atmosfere te se pritom generiraju posebni klimatski uvjeti u urbanim sredinama - urbana klima. Nju karakterizira stvaranje urbanog toplinskog otoka (UHI, eng. Urban Heat Island), tj. bitno viša temperatura zraka u urbanom području u odnosu na okolno ruralno područje. UHI je značajan ekološki problem povezan s mnogim negativnim posljedicama (zagrijavanje podloge, nepovoljni klimatski uvjeti u gradu, povećan zdravstveni rizik, povećane potrebe za vodom, povećana potrošnja energije itd.). Projekt je usmjeren na proučavanje urbane klime, klimatske varijabilnosti i manifestacija klimatskih promjena u Hrvatskoj te njihovog utjecaja na urbani okoliš, a može se podijeliti na dvije povezane teme:   1) Klimatska obilježja urbanih sredina i klimatsko modeliranje: proučavanje obilježja urbanih sredina u Hrvatskoj i modeliranje potencijala za primjenu zelene i plave infrastrukture kao mjere ublažavanja učinaka UHI-a uz procjenu njihove učinkovitosti. Glavna namjera ovog dijela projekta je ispitati utjecaj različitih tipova vegetacije i otvorenih vodenih površina na urbani okoliš uzimajući u obzir njegov geografski položaj, lokalna klimatska obilježja i utjecaj okoline. Nadalje, istražit će se moguće buduće promjene karakteristika urbanog klimatskog otoka uz uvažavanje regionalnih klimatskih projekcija i pretpostavljenih promjena morfologije grada te učinkovitost mjera ublažavanja UHI-a u uvjetima toplije klime.2) Klimatska varijabilnost i klimatske promjene u Hrvatskoj će biti analizirane i u kontekstu utjecaja globalnih i regionalnih procesa. Ispitat će se mogući utjecaj globalnih modova klimatske varijabilnosti na klimatske ekstreme. Očekuje se da će ovaj dio projekta omogućiti istraživanje mogućeg sinergijskog međudjelovanja klimatske varijabilnosti velike skale i urbane mikro-klime.    ]]></summary_hr><summary_en><![CDATA[Urbanization brings many benefits for the society by improving the standards of living, but on the other hand, it is also associated with unwanted environmental, social and economic consequences. One such concern is Urban Heat Island (UHI), the phenomenon characterized by considerably higher air temperatures in urban areas as compared to the surrounding suburban and rural areas. UHI is a serious environmental problem associated with multiple negative consequences (overheating of the pavement surfaces, discomfort for citizens, increased health risk, increased water demand, increased consumption of energy etc.). Climate variability and manifestations of climate change in Croatia with potential impact on urban environment are in the focus of this project. The proposed project addresses to two main topics:1.) Urban climate in Croatia and climate modelling: examination of urban climate in different Croatian cities. Modelling approach is expected to enable analyses of the urban climate as well as to estimate the potential for integrating of green and blue infrastructure in urban environment as mitigation measures for reducing UHI effects. Impacts of different types of vegetation and open water surfaces on urban micro-climate will be considered. Also, possible future changes in UHI load will be examined taking into account regional climate projections and urban morphology.     2.) Croatian climate variability and change will be analysed in the context of influence of global and regional processes. The possible impact of climate variability and climate extremes related to, for example, global modes of climate variability and heat waves will be considered as well. It is expected that results obtained in this part of the project will provide analysis of possible synergistic interaction between large-scale climate variability and urban micro-climate.]]></summary_en></project><project>
<id>14653</id><title_hr><![CDATA[RANONOVOVJEKOVNE POMORSKE KARTE JADRANSKOG MORA: IZVOR SPOZNAJA, SREDSTVO NAVIGACIJE I MEDIJ KOMUNIKACIJE]]></title_hr><title_en><![CDATA[]]></title_en><user_id>25896</user_id><user_firstLast_name>Josip Faričić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-7377</code><acronim><![CDATA[NACHAS]]></acronim><duration>04.10.2021 - 03.10.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Interdisciplinarno područje znanosti</scie_area_hr><scie_area_en>Interdisciplinary scientific area</scie_area_en><scie_field_hr>Geografija, </scie_field_hr><scie_field_en>Geography, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zadru]]></institution_hr><institution_en><![CDATA[University of Zadar]]></institution_en><team_members_id>865107</team_members_id><team_members_names><![CDATA[ Doktorand: Julijan Sutlović ]]></team_members_names><keywords_hr><![CDATA[kartografija, karta, pomorska karta, navigacija, Jadransko more]]></keywords_hr><keywords_en><![CDATA[cartography, map, nautical chart, navigation, Adriatic Sea]]></keywords_en><summary_hr><![CDATA[Stare karte moguće je istraživati s različitih motrišta, propitujući njihove najrazličitije komunikacijske kapacitete, posebno unutar  kartografskog diskursa višestrukog čitanja i tumačenja simbolične snage izvantekstualne komunikacije. Polazeći od dosadašnjih znanstvenih ostvarenja, ali i diskurzivnih postavki „nove kulturne kartografije“, ovim se projektom planira dopuniti postojeće spoznaje o ranonovovjekovnim pomorskim kartama Jadrana te na temelju interdisciplinarnoga pristupa, koji bi uvažio geografski, historiografski, geodetski i nautički diskurs, unaprijediti istraživanja pomorskih karata Jadrana, posebno u pogledu primjene kartometrijskih metoda i evaluacije kartografskih izvora kao medija komunikacije u prostoru i o prostoru. Radna je hipoteza da geografski sadržaj na pomorskim kartama ovisi o stupnju, odnosno količini i kvaliteti geografskih spoznaja o prikazanom prostoru, ali i o tome s kojega se motrišta neki prostor opaža i razmatra. Poseban aspekt istraživanja posvetit će se kartometrijskoj analizi uz korištenje različitih računalnih programa i alata, uključujući georeferenciranje starih pomorskih karata, vektorizaciju obalne crte i otoka te utvrđivanje kartografskih projekcija, mjerila karata, korelaciju orijentacijskog sustava s podatcima dobivenim iz modela za izračun povijesnih promjena magnetske varijacije, analizu preciznosti podataka o dubinama mora (koje su se sustavno na kartama počele prikazivati tek od druge polovine 18. st.) i dr. Na taj način trebao bi se dobiti jasniji uvid u upotrebljivost pomorskih karata kao sredstva na temelju kojega su se mogli dobiti pouzdani podatci iskoristivi u terestričkoj navigaciji u Jadranskom moru.]]></summary_hr><summary_en><![CDATA[Old maps can be studied from various standpoints and with various aims, examining their extremely varied communication capacities, particularly as part of recent cartographic discourse regarding multiple readings and interpreting the symbolic strength of extra-contextual communication. Starting from research achievements so far and the discourse tenets of a “new cultural cartography”, this project plans to supplement existing knowledge of early modern charts of the Adriatic and, pursuant to the interdisciplinary approach which acknowledges geographic, historiographic, geodetic and nautical discourses, advance research on nautical charts of the Adriatic, particularly in terms of applying cartometric methods and evaluating cartographic sources as media of communicating in space and about space. The working hypothesis is that the geographic content of nautical charts depended on the level, amount and quality of the geographical knowledge of the space depicted, but also on the standpoint from which that space was viewed and considered. A particular aspect of this research will be dedicated to a cartometric analysis using various computer programmes and tools, including georeferencing old nautical charts, the vectorisation of the coastlines of the mainland and islands, and establishing cartographic projections, map scales, the correlation of the orientation system with information taken from models for calculating historical changes in magnetic variation, analysis of precise data on sea depths (which only began to be shown systematically on charts in the latter half of the 18th century), and so on. In this way, a clearer picture should be gained of the usefulness of early modern charts as media for acquiring reliable data to use in terrestrial navigation in the Adriatic.]]></summary_en></project><project>
<id>14655</id><title_hr><![CDATA[Prilagodba uzgoja bijele ribe klimatskim promjenama]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5520</user_id><user_firstLast_name>Tin Klanjscek</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-6688</code><acronim><![CDATA[AqADAPT]]></acronim><duration>02.11.2021 - 01.11.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Interdisciplinarne prirodne znanosti, </scie_field_hr><scie_field_en>Interdisciplinary natural sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>865078</team_members_id><team_members_names><![CDATA[ Doktorand: Marija Purgar Purgar ]]></team_members_names><keywords_hr><![CDATA[modeliranje rasta riba, prilagodba agrikulture klimatskim promjenama, sedimenti, vodeni stupac, zdravlje riba, radiokronologija, frakcionacija izotopa]]></keywords_hr><keywords_en><![CDATA[modelling fish growth, adaptation of agriculture to climate change, sediment, water column, fish health, radiochronology, isotope fractionation]]></keywords_en><summary_hr><![CDATA[Uzgoj bijele ribe predstavlja važnu gospodarsku granu u Hrvatskoj sa značajnim potencijalom za rast. Budući da se uzgoj pretežno odvija u priobalnim kavezima ovisnim o uvjetima okoliša, rast i zdravlje riba, a samim time i proizvodnja, podložnisu klimatskim promjenama. Klimatske promjene i njihovi utjecaji postaju sve vidljiviji, te ugrožavaju opstojnost i razvoj akvakulture. Predloženi projekt će provođenjem temeljnih istraživanja prirodnih procesa i primjenom rezultata na biotehnologiju uzgoja riba te uz uspostavu baze znanja, doprinjeti stvaranju prilika za poboljšanje proizvodnje i smanjiti ugroze zbog utjecaja klimatskih promjena. Istraživanje će započeti identifikacijom najznačajnijih fizikalnih i bioloških procesa u akvakulturi povezanih s klimatskim promjenama. U tu svrhu prikupit će se i analizirati dugoročni povijesni trendovi u vodenom stupcu i sedimentu u područjima tipičnim za hrvatskuakvakulturu. Rezultati će se iskoristiti za razvoj modela rasta riba i razumijevanje zdravlja riba i mikrobioloških pokazatelja kao funkcije okolišnih uvjeta. Pomoću razvijenih modela i stečenih znanja predvidjet ćemo učinke najmanje tri scenarijaIPCC klimatskih promjena na proizvodnju i zdravlje riba, koje ćemo analizirati te ćemo za svaki od scenarija specificirati preporuke za prilagodbe proizvodnog procesa. Rezultati će biti objedinjeni u online bazu znanja u obliku koji je dostupan znanstvenicima, proizvođačima u akvakulturi i stvarateljima politika. Projekt, dakle, planira (i) temeljna istraživanja koja rezultiraju novim znanjem, podacima i modelima od interesa za znanstvenike, i (ii) primijenjena istraživanja usmjerena na pripremu akvakulture u Hrvatskoj za promjenu klime. Pokušat će se i uspostaviti suradnja s relevantnim EU projektima u tijeku (npr. ClimeFish) s ciljem postizanja sinergija i priključivanja konzorcija u budućim prijavama na EU projekte.]]></summary_hr><summary_en><![CDATA[Marine finfish aquaculture is an important industry in Croatia with significant growth potential. Since fish are cultured mainly in near-shore cages open to environmental conditions, their growth and well-being, and therefore the aquaculture production, is susceptible to climate change. The effects of the ongoing climate change are becoming increasingly visible, and threaten the viability and development of the aquaculture. AqADAPT will help turn the threats into an opportunity by conducting fundamental research into imminent threats to the aquaculture, and creating a know ledge base for adaptation of the industry. The research will start by focusing on identification of key physical and biological processes in aquaculture affected by climate change. To this end, we will collect and analyze both long-term historical trends, and the seasonal cycles in physical characteristics of the water column and sediments relevant tothe Croatian aquaculture. The results will be used to inform physiologically-based fish growth models, and analysis of threats to fish health and pools of microbiological contamination as functions of environmental conditions. We will use the modelsand knowledge to forecast effects of at least three IPCC climate change scenarios on aquaculture production and fish health. Finally, we will assess the predicted effects, and develop recommendations for adaptation for each of the scenarios. Theresults will be integrated into an on-line know ledge base in a form accessible to scientist, aquaculture producers, and decision-makers. The project therefore plans both (i) fundamental research resulting in new knowledge, data, and models of interest to scientists, and (ii) applied research aimed at preparing aquaculture industry in Croatia for the changing climate. An effort will be made to interact with relevant ongoing EU projects (e.g. ClimeFish), with the goal of achieving synergies and joining the consortium(s) in a future EU funding proposal. ]]></summary_en></project><project>
<id>14656</id><title_hr><![CDATA[Robotska percepcija stvarnog svijeta: razumijevanje složenih scena]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6310</user_id><user_firstLast_name>Robert Cupec</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-3889</code><acronim><![CDATA[COSPER]]></acronim><duration>15.09.2021 - 14.09.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera Osijek, Fakultet elektrotehnike, računarstva i informacijskih tehnologija Osijek]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Electrical Engineering, Computer Science and Information Technology Osijek]]></institution_en><team_members_id>865032</team_members_id><team_members_names><![CDATA[ Doktorand: Valentin Šimundić ]]></team_members_names><keywords_hr><![CDATA[robotika, računalni vid, prepoznavanje objekata, razumijevanje slike, učenje robota od strane čovjeka]]></keywords_hr><keywords_en><![CDATA[robotics, computer vision, object recognition, image understanding, robot training by human instructor]]></keywords_en><summary_hr><![CDATA[Sposobnost prepoznavanja objekata od interesa u složenim scenama te identificiranja njihovih dijelova relevantnih za rješavanje određenog zadatka predstavlja jednu od osnovnih funkcionalnosti inteligentnih robota namijenjenih radu u stvarnom svijetu. Mada je prepoznavanje objekata poznatog oblika dobro istražen problem za koji su ponuđena mnoga rješenja, prepoznavanje prvi put viđenih pripadnika određene prethodno naučene klase objekata na složenim scenama još je uvijek izazovan problem. Pored same detekcije objekata od interesa, za robotiku je od posebnog interesa identifikacija dijelova objekata relevantnih za obavljanje određenih zadataka. U predloženom projektu istraživat će se prepoznavanje objekata od interesa i njihovih dijelova na složenim scenama s ciljem razvoja novih kompetitivnih pristupa. Osim prepoznavanja objekata koji predstavljaju kruta tijela, razvijat će se i algoritmi za prepoznavanje artikuliranih objekata, tj. objekata sastavljenih od više krutih tijela povezanih gibljivim zglobovima, kao što su ormarići s ladicama, prozori, vrata, roboti itd., te estimacije njihovih kinematičkih parametara. Istraživat će se mogućnost prenošenja naučenog znanja o mogućnostima promjene konfiguracije artikuliranih objekata na druge pripadnike iste klase objekata. Također će se istraživati i strategije aktivnog vida, koje omogućuju povećanje uspješnosti prepoznavanja objekata odgovarajućim pozicioniranjem kamere montirane na robotski manipulator te interakcijom robota i objekta prepoznavanja. Treća tema predloženog projekta je učenje robota da obavlja neku radnju kroz demonstraciju od strane čovjeka. Razvijat će se metode koje omogućuju prilagodbu naučene radnje na različite objekte i različite situacije. Za rješavanje navedenih problema, koristit će se neuronske mreže i metodologija zasnovana na poliedarskim modelima klasa oblika, razvijena u okviru prethodnog projekta implementiranog od strane prijavitelja ovog projekta i njegovog istraživačkog tima. ]]></summary_hr><summary_en><![CDATA[Ability to recognize objects of interest in complex scenes as well as to identify their parts relevant for solving a particular task is one of the basic functionalities of intelligent robots designed to operate in the real world. Although recognition of objects of known and rigid shape is a thoroughly studied problem, for which a number of solutions are proposed, recognition of previously unseen objects, which are members of previously learned object classes, in complex scenes is still a challenging problem. Besides detection of objects of interest, a subject of special importance for robotics is identification of object parts relevant for solving a particular task. In the proposed project, recognition of objects of interest and their parts in complex scenes will be addressed, with the aim of developing novel competitive approaches. The second research topic of the project is development of novel methods for recognition of articulated objects, i.e. objects built from several rigid bodies connected by movable joints, such as drawers, doors, windows, robots etc., and estimation of their kinematic parameters. We will investigate possibilities of transferring learned knowledge about changing configurations of articulated objects from few representatives to other members of the same object class. Furthermore, active vision strategies will be studied, aimed at improving the object recognition performance by optimal positioning of the camera mounted on a robot arm and interaction between the robot and the target object. The third topic of the proposed project is training a robot to perform certain actions by demonstration performed by a human instructor. We will develop methods which allow adaptation of a learned action to different objects and different situations. For solving the addressed problems, we will use neural networks and the methodology based on polyhedral shape class model, developed in a previously implemented project of the applicant.]]></summary_en></project><project>
<id>14657</id><title_hr><![CDATA[Rotavirusi u ekosustavu Republike Hrvatske: molekularna epidemiologija i zoonotski potencijal]]></title_hr><title_en><![CDATA[]]></title_en><user_id>2597</user_id><user_firstLast_name>Dragan Brnić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-3623</code><acronim><![CDATA[REco]]></acronim><duration>13.09.2021 - 12.03.2026</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Veterinarska medicina, </scie_field_hr><scie_field_en>Veterinary medicine, </scie_field_en><institution_hr><![CDATA[Hrvatski veterinarski institut]]></institution_hr><institution_en><![CDATA[Croatian Veterinary Institute]]></institution_en><team_members_id>865085</team_members_id><team_members_names><![CDATA[ Doktorand: Valentina Kunić ]]></team_members_names><keywords_hr><![CDATA[Rotavirus, ekosustav, Republika Hrvatska, NGS, virusna metagenomika, cijeli genom, genotip ]]></keywords_hr><keywords_en><![CDATA[Rotavirus, Ecosystem, Croatia, NGS, viral metagenomics, whole genome, genotype]]></keywords_en><summary_hr><![CDATA[Rotavirusi, a posebno vrsta Rotavirus A (RVA), su široko rasprostranjeni uzročnici crijevnih infekcija visoke prevalencije i patogenosti u ljudi i različitih vrsti životinja. Dokazi učestalog križanja evolucije humanih i životinjskih  rotavirusa su do sada puno puta opisani. Međutim istraživanja životinjskih RVA sojeva znatno zaostaju za humanim, a naročito istraživanja sojeva podrijetlom od divljih životinja. Stoga je glavni cilj ovog projekta provesti sinkroniziranu prostorno-vremensku molekularnu epidemiološku studiju kako bi se procijenio zoonotski potencijal autohtonih rotavirusa A u ekosustavu Republike Hrvatske, slijedeći pri tome pristup „Jedno zdravlje? (One Health). Naša multidisciplinarna ideja istraživanja donosi cjelovitost i sveobuhvatnost, a takav usklađeni pristup veterinarske i humane medicine se smatra nužnim. Odabrana metodologija će nam pružiti jedinstvenu prigodu bolje upoznati genomsku strukturu, genotipski sastav genoma, filogenetsku srodnost i zoonotski potencijal hrvatskih autohtonih sojeva RVA istovremeno utvrđenih u domaćih i divljih životinja, u ljudi te okolišu. Povrh toga, NGS tehnologija primijenjena u postupku sekvenciranja cijelog genoma RVA će pri tome razotkriti raznolikost virusnog metagenoma u ekosustavu Republike Hrvatske, ali i moguće nove virusne prijetnje od javno-zdravstvenog značaja. Ovo istraživanje će po prvi puta definirati strukturu cijelog genoma RVA podrijetlom od nekoliko vrsti divljih životinja te donijeti novi pogled na njihovu evoluciju i sposobnost za pojavljivanje u populacijama ljudi i domaćih životinja. Novoosnovana autohtona RVA virusna banka će  zajedno s genotipskim bazama podataka omogućiti ubrzano genetsko praćenje novih emergentnih zoonotskih RVA sojeva. Ovim projektnim prijedlogom ćemo osnovati REco istraživačku skupinu s ciljem jačanja znanja, umrežavanja i konkurentnosti svakog člana u Europskom istraživačkom prostoru što će u konačnici rezultirati novim suradničkim istraživačkim inicijativama.]]></summary_hr><summary_en><![CDATA[Rotaviruses, especially the species Rotavirus A (RVA), are worldwide distributed enteric pathogens with high prevalence and pathogenicity in humans and variety of animals. The evidence for frequent intersections between the evolution of human and animal RVAs has been well documented. However the research on animal RVA strains is significantly lagging, especially on strains originating in wildlife. Therefore, the main aim of this project is to conduct a synchronized spatiotemporal molecular epidemiology study in order to assess the zoonotic potential of autochthonous RVA in Croatian ecosystem, by following the One Health concept. Our multidisciplinary research idea brings integrity and comprehensiveness in its approach and such concerted effort at the interface of veterinary medicine and public health is considered as warranted. By means of selected methodology, we will have a unique opportunity to get a closer look into genomic structure, genotype constellation, phylogenetic relatedness and zoonotic potential of Croatian autochthonous RVA strains simultaneously detected in domestic and wild animals, humans and environment. Moreover, the NGS technology applied for RVA whole genome sequencing will additionally reveal the diversity of viral metagenomes present in Croatian ecosystem and potentially expose new viral threats of public health importance. This study will be the first one defining a genetic backbone of RVAs in several wildlife species and bring a novel perspective on RVA evolution and the capacity of wildlife RVAs for the emergence into human and domestic animal populations. An autochthonous RVA virus bank will be formed, along with genotype databases enabling future seamless genetic tracking of novel emerging zoonotic strains. This project proposal will install a REco research group with the aim to boost knowledge, networking and competitiveness of each team member in the European Research Area, resulting in future novel collaborative research initiatives.]]></summary_en></project><project>
<id>14658</id><title_hr><![CDATA[Utjecaj inovativnih tehnologija na nutritivnu vrijednost, senzorska svojstva i oksidacijsku stabilnost djevičanskih maslinovih ulja iz hrvatskih autohtonih sorti maslina]]></title_hr><title_en><![CDATA[]]></title_en><user_id>13471</user_id><user_firstLast_name>Klara Kraljic</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-9876</code><acronim><![CDATA[CROInEVVO]]></acronim><duration>24.11.2021 - 23.05.2026</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Biotehnologija, </scie_field_hr><scie_field_en>Biotechnology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Food Technology and Biotechnology]]></institution_en><team_members_id>865229</team_members_id><team_members_names><![CDATA[ Doktorand: Katarina Filipan ]]></team_members_names><keywords_hr><![CDATA[djevičansko maslinovo ulje, nutritivna vrijednost, oksidacijska stabilnost, ultrazvuk, pulsirajuće električno polje, ubrzani toplinski tretman]]></keywords_hr><keywords_en><![CDATA[Virgin olive oil, nutritive value, oxidative stability, ultrasound, pulsed electrical field, rapid thermal treatment]]></keywords_en><summary_hr><![CDATA[Maslina je simbol mediteranske prehrane, glavni izvor masti i nutritivno vrijednih fitokemikalija. Ovisno o procesnim uvjetima proizvodnje djevičanskog maslinovog ulja (DMU), fitokemikalije prelaze iz ploda u ulje. Velik problem suvremene proizvodnje DMU je relativno slabo iskorištenje jer tijekom mljevenja ploda čak 20% stanica ostaje neoštećeno, a u razorenom materijalu dio ulja ostaje zarobljen u kompleksima sa koloidima čak i nakon miješenja. Ako tijekom mljevenja i miješenja nisu postignuti uvjeti za optimalnu aktivnost endogenih enzima ploda masline, veći dio polifenola ostat će u vegetabilnoj vodi, neće se formirati poželjna senzorska svojstva, a kvaliteta takvog DMU bit će slaba.Nedavna istraživanja izdvojila su primjenu ultrazvuka (UZV), pulsirajućeg električnog polja (PEP) te ubrzanog toplinskog tretmana (UTT) maslinovog tijesta prije miješanja, koja nudi mogućnost povećanja iskorištenja proizvodnje DMU s većim koncentracijama polifenola i poželjnih hlapljivih komponenti. Većina istraživača ističe presudnu važnost interakcije genetskih karakteristika sorte maslina i uvjeta primjene inovativnih tehnologija u proizvodnji DMOpći cilj ovog Projekta je stjecanje novih znanja o utjecaju UTT, UZV i PEP na nutritivnu vrijednost, senzorska svojstva, oksidacijsku stabilnost i iskorištenje proizvodnje DMU iz autohtonih hrvatskih sorti maslina. Budući da uvođenje inovacija u postojeće proizvodne sustave podrazumijeva dodatna financijska ulaganja, definirat će se ekonomski održiv postupak proizvodnje iz autohtonih sorti maslina primjenom inovativnih tehnologija. Statističkom obradom i matematičkim modeliranjem velikog broja prikupljenih podataka definirat će se precizni modeli procjene trajnosti DMU proizvedenih klasičnim i inovativnim tehnologijama. Kroz karakterizaciju i diferencijaciju monosortnih DMU iz odabranih sorti, ostvarit će se značajno proširenje baze podataka nutritivnih i senzorskih profila DMU iz hrvatskih autohtonih sorti.]]></summary_hr><summary_en><![CDATA[Depending on the processing conditions for the production of virgin olive oil (VOO), phytochemicals are extracted from fruit to oil. The problem of modern production of VOO is relatively poor yield. Reason is insufficient milling which leaves as much as 20% of cells intact and part of the oil remains trapped in colloidal complexes even after malaxation. If, during milling and malaxation, conditions are not met for optimal activity of endogenous enzymes from olive fruit, most of the polyphenols will remain in vegetable water, the desired sensory properties will not be formed, and the quality of such VOO will be poor. Recent research has singled out the use of ultrasound (US), pulsed electrical field (PEF) and rapid thermal treatment (RTT) of olive paste before malaxation, which offers the possibility to increase the yield of VOO production with higher concentrations of polyphenols and desirable volatile components. Most researchers emphasize the crucial importance of interaction between genetic characteristics of olive varieties and conditions of application of innovative technologies in VOO production. The general objective of this project is to acquire new knowledge about the influence of RTT, US and PEF on nutritive value, sensory characteristics, oxidative stability and yield of VOO production from autochthonous Croatian olive varieties. Since the introduction of innovations into existing production systems implies additional financial investments, an economically viable production process from Croatian olive varieties will be defined by applying innovative technologies. The statistical methods and mathematical modelling of a large number of collected data will define precise models for estimating the shelf life of VOO extracted by classical and innovative technologies. Through the characterization of monovarietal VOO from selected varieties, the database of nutritional and sensory profiles of VOO of Croatian autochthonous varieties will be significantly expanded]]></summary_en></project><project>
<id>14659</id><title_hr><![CDATA[Inovativna rješenja u katalitičkim proizvodnim procesima za potrebe farmaceutske industrije (CAT PHARMA)]]></title_hr><title_en><![CDATA[]]></title_en><user_id>355</user_id><user_firstLast_name>Srećko Kirin</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-7366</code><acronim><![CDATA[]]></acronim><duration>01.11.2021 - 31.01.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>865090</team_members_id><team_members_names><![CDATA[ Doktorand: Marija Bakija ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>14660</id><title_hr><![CDATA[Hiperheurističko oblikovanje pravila raspoređivanja]]></title_hr><title_en><![CDATA[]]></title_en><user_id>24153</user_id><user_firstLast_name>Marko Đurasević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-1901</code><acronim><![CDATA[HyDDRa]]></acronim><duration>09.04.2024 - 08.04.2028</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>867683</team_members_id><team_members_names><![CDATA[ Doktorand: Josip Hrvatić ]]></team_members_names><keywords_hr><![CDATA[raspoređivanje, heuristički algoritmi, hiperheuristike, evolucijsko računarstvo, genetičko programiranje]]></keywords_hr><keywords_en><![CDATA[scheduling, heuristic algorithms, hyperheuristics, evolutionary computation, genetic programming]]></keywords_en><summary_hr><![CDATA[Raspoređivanje je proces u kojemu je određeni skup poslova (aktivnosti) potrebno dodijeliti ograničenom skupu strojeva (sredstava), s ciljem optimiranja korisnički definiranih kriterija i zahtjeva. Zbog svoje složenosti većina problema raspoređivanja ne može se riješiti egzaktno, već se za njihovo rješavanje koriste različiti heuristički i metaheuristički postupci. Posebice veliki problem predstavljaju dinamički problemi raspoređivanja, kod kojih informacije o problemu (dolazak poslova u sustav, trajanja izvođenja poslova, kvarovi strojeva), nisu poznate unaprijed, već postaju poznate tijekom rada sustava. Umjesto ručnog definiranja prilagođenih algoritama raspoređivanja za različite kombinacije oganičenja i kriterija, hiperheurističkim postupcima moguće je automatski oblikovati postupak raspoređivanja za zadani problem. Hiperheuristički postupci su optimizacijske metode koje ne pronalaze rješenje zadanog problema, već optimiraju postupak rješavanja problema; najpoznatiji primjeri hiperheuristika su genetičko programiranje i inačice evolucijskih algoritama.Ovaj je projekt usmjeren na primjene različitih hiperheurističkih metoda s ciljem izrade pravila raspoređivanja za dinamičke probleme raspoređivanja koje nisu iscrpno proučene u literaturi. U ovom projektnom prijedlogu fokus je stavljen na okruženje nesrodnih strojeva i njegove varijante. Projektni prijedlog obuhvaća nekoliko smjerova istraživanja kojima je cilj poboljšanje kvalitete hiperheuristika u oblikovanju pravila raspoređivanja. Također, jedan od ciljeva projekta je i proširenje ove paradigme na srodne optimizacijske probleme, kao što su raspoređivanje uz ograničenja sredstava te usmjeravanje vozila. Projektni tim posjeduje potrebno iskustvo u primjeni hiperheurističkih i optimizacijskih postupaka te objavljene preliminarne rezultate koji upućuju na isplativost daljnjeg istraživanja u opisanom području.]]></summary_hr><summary_en><![CDATA[Scheduling is a process in which a certain set of tasks (activities) need to be assigned to a limited set of machines (resources) to optimize user-defined criteria and requirements. Because of its complexity, most of the scheduling problems cannot be solved exactly, but different heuristic and metaheuristic procedures are used for their solution. A particularly big challenge is dynamic scheduling, where information about the problem (job release dates, processing time, machine failures) is not known in advance but becomes known during system operation. Instead of manually defining customized scheduling algorithms for different combinations of constraints and criteria, hyperheuristic procedures can automatically form the scheduling algorithm for a given problem. Hyperheuristic procedures are optimization methods that do not find the solution to the problem, but optimize the problem-solving algorithm; the most common examples of hyperheuristics are genetic programming and variants of evolutionary algorithms. This project focuses on the application of various hyperheuristic methods with the aim of developing dispatching rules for dynamic scheduling problems that have not been thoroughly studied in the literature. In this project proposal, the focus is placed on the unrelated machines scheduling environment and its variants. The project proposal encompasses several research directions aimed at improving the quality of hyperheuristics in automatic developing of the dispatching rules. Additionally, one of the project&#39;s goals is to extend this paradigm to related optimization problems, such as scheduling with resource constraints and vehicle routing. The project team possesses the necessary experience in applying hyperheuristics and optimization methods and has published preliminary results indicating the viability of further research in this area.]]></summary_en></project><project>
<id>14661</id><title_hr><![CDATA[Milimetarska i submilimetarska opažanja Sunčeve kromosfere pomoću ALMA-e]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6078</user_id><user_firstLast_name>Roman Brajša</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-4526</code><acronim><![CDATA[MSOC]]></acronim><duration>02.11.2021 - 01.11.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Geodetski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Geodesy]]></institution_en><team_members_id>865039</team_members_id><team_members_names><![CDATA[ Doktorand: Filip Matković ]]></team_members_names><keywords_hr><![CDATA[kromosfera, radioastronomija, rotacija Sunca, prominencije, eruptivni procesi]]></keywords_hr><keywords_en><![CDATA[chromosphere, radio astronomy, solar rotation, prominences, eruptive processes]]></keywords_en><summary_hr><![CDATA[	Sunčeva kromosfera je dinamički sloj atmosfere Sunca smješten između fotosfere i korone koji igra važnu ulogu u prijenosu materije i energije u vanjske slojeve te je presudan za razumijevanje zagrijavanja korone. Potpuno razumijevanje ovog sloja još uvijek je nedostižno, uglavnom zbog nedostatka prikladnih opažačkih instrumenata i mjerenja. Cilj ovog projekta je analiza podataka iz solarnih opažanja s teleskopa Atacama Large Millimeter/submillimeter Array (ALMA), naprednog i trenutno najvećeg astronomskog instrumenta na Zemlji, kojim se mogu istraživati gotovo svi tipovi nebeskih objekata, uključujući Sunce. Glavna prednost solarnih opažanja s ALMA-om je mapiranje Sunčeve kromosfere s dosad nedostignutom prostornom, vremenskom i spektralnom razlučivosti u rasponu valnih duljina između 0,3 mm i 8,6 mm. ALMA se također može koristiti kao približno linearni termometar - izmjerena temperatura sjaja izravno je proporcionalna temperaturi plina opažane strukture ili sloja koji je izvor detektiranog kontinuiranog zračenja u Sunčevoj atmosferi. Visina stvaranja kontinuiranog zračenja povećava se s povećanjem valne duljine promatranja koja, zajedno s visokom spektralnom razlučivosti ALMA-e, omogućuje vrlo precizno mjerenje temperature kromosfere kao funkcije visine. Sve navedene prednosti ALMA-e omogućuju istraživanje trodimenzionalne strukture kromosfere i njenih mnogobrojnih zanimljivih dinamičkih pojava. Glavni cilj predloženog istraživanja je poboljšati razumijevanje kromosfere Sunca pomoću novog naprednog instrumenta ALMA-e. Da bismo ostvarili taj cilj, namjeravamo se usredotočiti na četiri glavne teme: analizu struktura velikih razmjera opažanih ALMA-om, analizu struktura malih razmjera opažanih ALMA-om, modeliranje i tumačenje ALMA promatranja te njihov utjecaj na druga područja fizike Sunca.]]></summary_hr><summary_en><![CDATA[Solar chromosphere is a dynamic interface layer of the Sun&#39;s atmosphere located between the photosphere and corona which plays an important role in transporting energy and matter into the outer layers and is crucial for understanding of coronal heating. Full understanding of this layer is still elusive mostly due to the lack of suitable measurements and instruments. The aim of this project is to utilize solar observations with the Atacama Large Millimeter/submillimeter Array (ALMA), a new state-of-the-art and currently the world largest ground-based astronomical facility, capable of observing almost all types of celestial objects including the Sun. The main advantage of ALMA solar observations is mapping of the solar chromosphere with an unprecedented spatial, temporal, and spectral resolution in the wavelength range between 0.3 mm and 8.6 mm. It can also be used as an approximately linear thermometer - the measured brightness temperature is directly proportional to the gas temperature of the observed structure or the continuum-forming layer in the solar atmosphere. Formation height of the continuum radiation increases with increasing wavelength of the observation which, coupled with ALMA&#39;s high spectral resolution, enables very accurate measurements of chromosphere&#39;s temperature as a function of height. All of these capabilities of ALMA will provide the possibility to investigate full 3D structure of the chromosphere and many interesting dynamic phenomena therein.  The main goal of the proposed research is to improve understanding of the solar chromosphere using the new advanced instrument ALMA. To achieve this goal we intend to focus on four main objectives: analysis of large scale structures observed by ALMA, analysis of small scale structures observed by ALMA, modeling and interpretation of ALMA observations, and impact on other fields of solar physics.]]></summary_en></project><project>
<id>14663</id><title_hr><![CDATA[Internet stvari: istraživanja i primjene ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>7605</user_id><user_firstLast_name>Petar Šolić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-7665</code><acronim><![CDATA[IoTRA]]></acronim><duration>01.12.2021 - 30.11.2025</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Fakultet elektrotehnike, strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Electrical Engineering, Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>865206</team_members_id><team_members_names><![CDATA[ Doktorand: Kristina Zovko ]]></team_members_names><keywords_hr><![CDATA[Internet stvari, RFID, uređaji niske potrošnje, pametna okruženja, prototipiranje uređaja]]></keywords_hr><keywords_en><![CDATA[Internet of Things (IoT), RFID, Low Power Devices, Smart Environemnt, Device Prototyping]]></keywords_en><summary_hr><![CDATA[Internet stvari je postala najistraživanija tema u području elektrotehnike i računarstva. Postojeće tehnološke infrastrukture se trenutno redizajniraju s ciljem organizacije mrežnih arhitektura potrebnih za komunikaciju milijardi uređaja u realnom vremenu, pohrane velike količine podataka i korištenja istih za izgradnju budućih pametnih okruženja. Posljedično, pojavit će se nove usluge i tehnologije koje će olakšati život.Cilj ovog projektnog prijedloga odgovara temi vizije Interneta stvari, a omogućava  smanjenje robusnosti i energetskih zahtjeva IoT uređaja, održivost i što je najvažnije primjenjivost u skoroj budućnosti. Temeljem zapaženih nedostataka postojeće tehnologije, cilj je dati nove prijedloge koje smanjuju ograničenja, te koriste stečena znanja s ciljem izrade prototipova poboljšanih uređaja. Kao posljedica, izraditi će se skupina novih poboljšanih prototipova testiranih u realnim uvjetima koje omogućuju takvu viziju.]]></summary_hr><summary_en><![CDATA[Internet of Things (IoT) became the hottest research topic in the field of electronics and computer science. New upcoming technological infrastructures are currently being redesigned in order to handle real time communication between billions of devices, storing their big data, analyzing and using the data to manipulate the future smart environments. Consequently, new services and technologies will emerge, and help in making life easier.The aim of this proposal goes in-line with the hottest research topics enabling IoT vision, while proposing new advances that make IoT technology less robust, less expensive, less power hungry, sustainable and the most important, applicable in the close future. In particular, the proposal is oriented toward gathering the state of the art IoT enabling technologies available on the market in order to provide in-depth analysis of their performances. Based on the noticed disadvantages of state of the art technologies, the goal is to provide new proposals that can enhance limitations, bring new related insights and use acquired knowledge to construct prototypes of these new enhanced devices. As a consequence, a set of new robust prototypes tested in real environments that can help in accomplishing such vision will be provided. ]]></summary_en></project><project>
<id>14664</id><title_hr><![CDATA[Radionuklidi u dječjoj hrani i razvoj metoda za određivanje njihovih niskih aktivnosti ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>19525</user_id><user_firstLast_name>Ivana  Tucaković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-8577</code><acronim><![CDATA[RiChFALL]]></acronim><duration>16.03.2022 - 15.03.2026</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Interdisciplinarne prirodne znanosti, </scie_field_hr><scie_field_en>Interdisciplinary natural sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>865391</team_members_id><team_members_names><![CDATA[ Doktorand: Tomislav Ilievski ]]></team_members_names><keywords_hr><![CDATA[Dječja hrana,  radionuklidi, ingestijska doza, aktivni štitovi, niske aktivnosti, automatizacija i integracija metoda separacije i detekcije]]></keywords_hr><keywords_en><![CDATA[Children food, radionuclides, ingestion dose, active shields, low activity, automatization and integration of separation and detection methods]]></keywords_en><summary_hr><![CDATA[Za ljudsko zdravlje vrlo je važno utvrđivanje točnog unosa prirodnih i umjetnih radionuklida u organizam kako bi se što pouzdanije mogao procijeniti zdravstveni rizik od unutarnjeg ozračenja kako za pojedinca tako i za pojedine starosne skupine u populaciji, a osobito za djecu -  populacijsku skupinu najosjetljiviju na izloženost radionuklidima. Stoga su u svijetu provedene brojne studije o sadržaju radionuklida u mlijeku koji predstavlja glavnu osnovnu hranu u prvih šest mjeseci prehrane djece. No, postoji nedostatak podataka o sadržaju radionuklida u drugim vrstama dječje hrane koja se koristi nakon navršenih šest mjeseci života. Prema dostupnim izvorima, u našoj zemlji nisu do sada rađena sustavna istraživanja o radiološkoj ispravnosti dječje hrane pa tako ni procjene rizika od unutarnjeg ozračenja za tu populaciju. Stoga smatramo da ovo istraživanje ima općedruštvenu važnost jer bi se po prvi puta utvrdilo kakva je kvaliteta dječje hrane s obzirom na sadržaj radionuklida te kojem su riziku naša djeca u tom pogledu izložena. Jedan od glavnih ciljeva istraživanja je provesti sveobuhvatnu analizu dugoživučih alfa, beta i gama emitera, kako prirodnih tako i umjetnih, u gotovoj dječjoj hrani dostupnoj na tržištu te sirovinama za njenu proizvodnju. Stoga se ovim projektom planira poboljšanje postojećih i razvijanje novih metoda određivanja niskih aktivnosti gama emitera uvođenjem pasivnih i aktivnih štitova u svrhu redukcije pozadinskog zračenja, te razvoj novih automatiziranih postupaka istovremene izolacije i separacije ciljanih radionuklida iz kompleksnih uzoraka s ciljem pojednostavljenja i ubrzanja u odnosu na postojeće metode. Ovim projektom razvijene metode moći će se primjenjivati i u drugim područjima kao što je nuklearna forenzika, karakterizacija materijala, praćenje kontaminacija zbog ispusta iz nuklearnih elektrana, u slučaju izvanrednih događaja ili pak pri skladištenju ili odlaganju radioaktivnog otpada i drugo.  ]]></summary_hr><summary_en><![CDATA[The accurate determination of the natural and artificial radionuclides intake in human body is very important in order to ascertain the health risk of internal irradiation of the individual as well as for different age groups in the population, especially for children - the most vulnerable to exposure to radionuclides . Therefore, numerous studies on the content of radionuclides in milk, the main food in the first six months of children&#39;s diet, have been conducted all over the world. However, there is a lack of data in other types of children food used in nutrition after six months of age. According to available sources for our country, there was no systematic research carried out on radiological safety of children food and neither for the risk assessment of internal irradiation for this population. Therefore, we consider this research to be of general importance because, for the first time, it would reveal the quality of children food with regard to the content of radionuclide and it would also indicate the level of risk of children&#39;s exposure. One of the main research goals is to carry out a comprehensive analysis of long-lived alpha, beta and gamma emitters, both natural and artificial, in ready-to-eat children food available on the market, and in raw materials for its production. Therefore, within this project we tend to improve the existing and develope the novel methods for low level activity gamma emitters determination by introducing passive and active shields to reduce the background signal, as well as  to develop the new automated simultaneous isolation and separation procedures of target radionuclides from complex samples. Additional value of this project is that the methods here developed can then also be applied in other domains such as nuclear forensics, material characterization, contamination monitoring due to the discharge from nuclear power plants, in the emergency situations or in the storage or disposal of radioactive waste monitoring, etc.]]></summary_en></project><project>
<id>14666</id><title_hr><![CDATA[DanuP-2-Gas: Innovative model to drive energy security and diversity in the Danube Region via combination of bioenergy with surplus renewable energy]]></title_hr><title_en><![CDATA[]]></title_en><user_id>7612</user_id><user_firstLast_name>Mario Vašak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-1922</code><acronim><![CDATA[]]></acronim><duration>21.10.2021 - 31.01.2026</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>865172</team_members_id><team_members_names><![CDATA[ Doktorand: Antonio Karneluti ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>14667</id><title_hr><![CDATA[Autonomni sustav za pregled i predviđanje integriteta prometne infrastrukture, ASAP]]></title_hr><title_en><![CDATA[]]></title_en><user_id>22453</user_id><user_firstLast_name>Ivan Duvnjak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-5362</code><acronim><![CDATA[]]></acronim><duration>01.12.2021 - 01.12.2025</duration><status>Prekinut</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Temeljne tehničke znanosti, </scie_field_hr><scie_field_en>Basic engineering sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Građevinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Civil Engineering]]></institution_en><team_members_id>865236</team_members_id><team_members_names><![CDATA[ Doktorand: Jurica Pajan ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>14668</id><title_hr><![CDATA[Regulacija mitofagije posredovane receptorom u stanicama eritroidne loze - MitoReg]]></title_hr><title_en><![CDATA[]]></title_en><user_id>62</user_id><user_firstLast_name>Ivana Novak Nakir</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-4248</code><acronim><![CDATA[]]></acronim><duration>04.10.2021 - 27.11.2026</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Split School of Medicine]]></institution_en><team_members_id>865165</team_members_id><team_members_names><![CDATA[ Doktorand: Ana Rožić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>14671</id><title_hr><![CDATA[Nova paradigma utvrđivanja odbacivanja presatka srca: dijagnostika fazno-kontrastnim oslikavanjem X-zrakama proizvedenim sinkrotronom (GRAFT-XPCI)]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3349</user_id><user_firstLast_name>Maja Čikeš</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-2285</code><acronim><![CDATA[]]></acronim><duration>01.02.2022 - 31.01.2026</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Clinical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>865272</team_members_id><team_members_names><![CDATA[ Doktorand: Nikola Škreb ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>14672</id><title_hr><![CDATA[KK.01.1.1.07.0028: Razvoj ekspertnog sustava mjerenja parametara udara munje i zaštite lopatica vjetroagregata radi smanjenja kvarova i zastoja]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5633</user_id><user_firstLast_name>Božidar  Filipović-Grčić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-7744</code><acronim><![CDATA[]]></acronim><duration>21.07.2021 - 20.07.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>865063</team_members_id><team_members_names><![CDATA[ Doktorand: Franjo Vuković ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>14676</id><title_hr><![CDATA[Modeliranje i simulacija u razvoju naprednih materijala]]></title_hr><title_en><![CDATA[]]></title_en><user_id>12813</user_id><user_firstLast_name>Kristina Marković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-3063</code><acronim><![CDATA[SIMMAT]]></acronim><duration>01.12.2021 - 30.11.2025</duration><status>Prekinut</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, </scie_field_hr><scie_field_en>Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Tehnički fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Engineering]]></institution_en><team_members_id>865243</team_members_id><team_members_names><![CDATA[ Doktorand: Jasen Zenzerovic ]]></team_members_names><keywords_hr><![CDATA[Ponašanje materijala, Eksperimentalno ispitivanje, Karakterizacija, Inverzno modeliranje, Simulacija]]></keywords_hr><keywords_en><![CDATA[Material behavior,  Experimental testing, Characterization, Inverse modeling, Simulation]]></keywords_en><summary_hr><![CDATA[Visoka razina tržišnog natjecanja danas postavlja putokaze za razvoj novih tehnologija u dizajnu strojarskih konstrukcija i predstavlja značajne izazove konstruktorima. Razvoj novih tehnologija proširuje mogućnosti optimizacije dizajna strojarskih konstrukcija te kao imperativ postavlja potrebu istraživanja ponašanja inovativnih materijala koji mogu ispuniti zahtjeve ovih tehnologija, te kriterije čvrstoće, krutosti i stabilnosti konstrukcija. Tijekom rada na projektu BIOMAT HRZZ-a koji je u završanoj fazi provedbe kontinuirano se vrši istraživanje mogućnosti primjene razvijene metodologije za modeliranje i simulaciju ponašanja biomaterijala na inovativne materijale. Posebnost u strukturi biomaterijala koja se promatra kao korelacija matrice i kolagenskih vlakana i njihova sličnost s kompozitnim strukturama, uz analizu potencijala za istraživanje inovativnih materijala usmjerava istraživanje prema kompozitnim strukturama. Razvoj novih tehnologija fokus projekta dodatno usmjerava prema istraživanju ponašanja ovih materijala dobivenih aditivnim tehnologijama. Planirano istraživanje predstavlja nastavak istraživanja na način da će se razvijena metodologija, efikasna kako za metalne materijale tako i biološke, prilagoditi i primijeniti na karakterizaciju, simulaciju te analizu ponašanja materijala dobivenih aditivnim tehnologijama. Stoga je osnovni cilj projekta utvrditi i provesti postupak modeliranja ponašanja kompozitnih materijala te dodatno titanijevih legura izrađenih aditivnim tehnologijama, validirati rezultate ispitivanjem fotoelastičnih materijala i preporučiti im primjenu. On će biti ostvaren kroz postupke eksperimentalnog istraživanja ponašanja materijala s fokusom na kompozitne materijale dobivene aditivnim tehnologijama uz testna ispitivanja titanijevih legura i fotoelastičnih materijala, matematičkog modeliranja uz optimizaciju identifikacije parametara materijala i simulaciju ponašanja materijala te validaciju rezultata fotoelastičnim ispitivanjem. ]]></summary_hr><summary_en><![CDATA[High level of competitiveness in the marketplace today increases importance of development of new technologies in mechanical structures design and represents challenges for constructors. The development of new technologies expands the possibilities of design optimization and raises the need for research of the innovative materials behavior which can meet the criteria of strength, rigidity and stability of construction. Within the framework of the project BIOMAT (CSF) the application of developed methodology for the characterization of biomaterials on innovative materials has been explored. Attention is given here to the biomaterials structure that is considered through the correlation of matrices and collagen fibers which appears similar to the composite structures. Consequently, with an analysis of the potential for the exploration of innovative materials, it directs the proposal of this research to the composite structures. The development of new technologies directs the research to the behavior of these materials produced using additive technologies. Thus the planned research is a continuation of previous research in a way that the developed methodology, efficient for both metallic and biomaterials, will be adapted and applied to the characterization, simulation and behavior analyses of innovative materials produced by additive technologies. Therefore, the main research goal is to determine and perform the characterization of composite materials produced by additive technologies, validate results by photoelasticimetry and recommend their application. It will be accomplished through:  experimental research of material behavior with focus on composite materials produced by additive technologies together with testing other materials (titanium alloys and photoelastic materials), mathematical modeling with optimization of material parameter identification and simulation of material behavior followed by validation of results by photoelastic testing.]]></summary_en></project><project>
<id>14680</id><title_hr><![CDATA[Međuusporedba metoda mjerenja denudacije krša]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6006</user_id><user_firstLast_name>Kristina Krklec</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-1788</code><acronim><![CDATA[KADEME]]></acronim><duration>11.04.2023 - 10.04.2026</duration><status>Prekinut</status><financ_value>0,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Geologija, </scie_field_hr><scie_field_en>Geology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Agronomski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Agriculture]]></institution_en><team_members_id>866716</team_members_id><team_members_names><![CDATA[ Doktorand: Katarina Matan ]]></team_members_names><keywords_hr><![CDATA[denudacija, trošenje stijena, tlo, krš, špilja]]></keywords_hr><keywords_en><![CDATA[denudation, rock weathering, soil, karst, cave]]></keywords_en><summary_hr><![CDATA[Denudacija površine temeljni je proces razvoja reljefa i tla. Otapanjem karbonata ostaje netopivi ostatak iz kojeg se može razviti tlo. Stoga je poznavanje brzine trošenja stijena i denudacije važno za evaluaciju potrebnog vremena za razvoj tla. Postoji nekoliko različitih metodoloških pristupa za mjerenje stope denudacije. Najčešće se koriste: izlaganje stijenskih pločica uvjetima u okolišu; upotreba mikro-erozijskog metra; mjerenje koncentracije kozmogenih radionuklida na izloženim stijenama i mjerenje hidrokemijskih značajki vode u svrhu određivanja količine otopljenih karbonatnih stijena. Svaka metoda ima prednosti i nedostatke i ne postoji konsenzus o tome koja metoda pruža najpouzdanije vrijednosti stope denudacije, štoviše, zabilježene su značajne razlike u rezultatima među metodama. Stoga ovo istraživanje ima za cilj identificirati metode koje bi mogle pružiti pristrane rezultate i ukazati na prednosti i nedostatke svake metode, kako bi se istraživačima olakšao odabir bolje metode ovisno o ciljevima njihovih istraživanja.Metode će se primijeniti na dvije različite lokacije pod utjecajem mediteranske klime, ali s vrlo različitom debljinom tla. Ovaj pristup važan je za vrednovanje sprege stope denudacije i debljine tla, te za utvrđivanje jesu li rezultati usporedbe metoda sustavni na mjestima s promjenjivom značajkama. Dobivene stope denudacije koristiti će se za procjenu produkcije materijala na lokacijama istraživanja, odnosno za proučavanje potencijalne proizvodnje tla ovisno o denudaciji. Važnost ovoga ogleda se u činjenici da je u scenariju erozije tla u mediteranskoj regiji važno znati potencijal oporavka tih sustava.]]></summary_hr><summary_en><![CDATA[Denudation of earth surface is the fundamental process governing the landscape and soil development. The dissolution of carbonates results in insoluble material of these rocks being available for the development of soils. Therefore, knowing rock denudation-weathering rates is important to evaluate the time required for a certain soil to develop. There are several different methodological approaches to measure denudation rate. The must commonly used are: the exposure of rock tablets to the natural environment; the use of micro-erosion meters; measuring the concentration of cosmogenic radionuclides on exposed rocks and measuring water hydrochemistry to infer amount of carbonates being dissolved. Every method has pros and cons and there is no consensus on which method provides the more reliable denudation rates, furthermore, significant differences among methods have been reported. Therefore, this investigation aims to identify methods that could provide biased results and as well to report the strengths and flaws of every method, to help researchers to select the better methods depending on the goals of their particular studies.The methods will be applied at two different locations affected by Mediterranean climate, but with very different soil thickness. This approach is important to evaluate the feedback of soil thickness on denudation rates, and confirm if the conclusions from the method comparison are systematic on sites with variable characteristics. The denudation rates obtained will be used to evaluate the production of material at the studied sites to study the potential production of soil depending on denudation. This is important, since in a scenario of soil erosion in the Mediterranean region, it is important to know the potential recovery of these systems. ]]></summary_en></project><project>
<id>14681</id><title_hr><![CDATA[Razvoj DIV elastične kopče]]></title_hr><title_en><![CDATA[]]></title_en><user_id>7606</user_id><user_firstLast_name>Ivo Haladin</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-9981</code><acronim><![CDATA[]]></acronim><duration>01.11.2021 - 31.10.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Građevinarstvo, </scie_field_hr><scie_field_en>Civil engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Građevinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Civil Engineering]]></institution_en><team_members_id>865133</team_members_id><team_members_names><![CDATA[ Doktorand: Krešimir Burnać Burnać ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>14682</id><title_hr><![CDATA[Inovativna rješenja za racionalizaciju upotrebe bentonita u postizanju proteinske stabilnosti bijelih vina]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4924</user_id><user_firstLast_name>Igor Lukić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-5500</code><acronim><![CDATA[INNOSTAB]]></acronim><duration>23.08.2021 - 22.08.2025</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Prehrambena tehnologija, </scie_field_hr><scie_field_en>Food technology, </scie_field_en><institution_hr><![CDATA[Institut za poljoprivredu i turizam]]></institution_hr><institution_en><![CDATA[Institute of Agriculture and Tourism in Poreč]]></institution_en><team_members_id>865023</team_members_id><team_members_names><![CDATA[ Doktorand: Doris Delač Salopek ]]></team_members_names><keywords_hr><![CDATA[proteinska stabilnost vina, proteini povezani s patogenezom, bentonit, bistrenje vina, kvaliteta vina, metabolomika, proteomika, Malvazija istarska]]></keywords_hr><keywords_en><![CDATA[wine protein stability, pathogenesis-related proteins, bentonite, wine fining, wine quality, metabolomics, proteomics, Malvazija istarska]]></keywords_en><summary_hr><![CDATA[Bijela vina s razvijenim proteinskim zamućenjem koje potječe od agregacije tzv. proteina povezanih s patogenezom (PR proteini) nisu utrživa. Standardni, općeprihvaćeni postupak za prevenciju proteinskog zamućenja je uklanjanje proteina adsorpcijom na bentonit prije punjenja u boce, kojeg, međutim, odlikuju bitni nedostaci, uključujući gubitke količina i kvalitete vina. Do danas predložene alternative bentonitu uglavnom su se pokazale nepraktičnim, skupim, s različitim negativnim nuspojavama, još uvijek su na razini istraživanja ili su pokušaji obustavljeni, te nisu dopuštene legislativom EU. Glavni cilj ovog Projekta je razvoj inovativnih tehnoloških rješenja za smanjenje potrebne količine bentonita, uz očuvanje ili poboljšanje kvalitete vina. Ciljevi uključuju: (1) poboljšanje proteinske stabilnosti vina regulacijom parametara u berbi i pred-fermentativnoj preradi grožđa, (2) umanjenje koncentracije PR proteina fermentacijom s nekonvencionalnim kvascima, (3) umanjenje potrebne doze bentonita iskorištenjem komplementarnih afiniteta bentonita i drugih enoloških sredstava prema PR proteinima te (4) istraživanje uzroka potreba za velikim količinama bentonita u bistrenju bijelog vina kultivara Malvazija istarska. Istraživanje će se provesti kroz niz tehnoloških pokusa podržanih snažnom analitičkom platformom, uključujući konvencionalne instrumentalne analize nadopunjene sveobuhvatnom proteomikom i metabolomikom, za koje se očekuje da će proizvesti originalne i napredne podatke objavljive u znanstvenim časopisima visokog faktora odjeka. Predložena rješenja u skladu su s trenutačnim zakonodavnim okvirom, ekonomski su izvediva i ekološki održiva, ne uključuju dodatna kapitalna ulaganja te bi se mogla praktično usvojiti bez odgode. Time bi se proizvođačima omogućila proizvodnja većih količina kvalitetnijeg vina te jačanje njihove konkurentnosti na tržištu, što bi moglo pozitivno utjecati na opću kvalitetu života u gospodarstvima s vinarskom proizvodnjom.]]></summary_hr><summary_en><![CDATA[White wines with developed protein haze/sediment, originating from the aggregation of pathogenesis-related (PR) grape proteins, are not marketable. The current practice to prevent protein haze is to remove proteins before bottling by adsorption onto bentonite, which has several drawbacks, including losses in wine quantity and quality. Alternatives to bentonite proposed up to date mostly lacked practicality and exhibited technical shortcomings or negative side-effects, and are still on research level or discontinued, and not allowed by EU legislation. The main goal of the Project is to develop innovative technological solutions for reducing the required amount of bentonite, at the same time preserving or improving wine quality. The objectives include: (1) improving wine protein stability by regulating grape harvest and pre-fermentative processing parameters, (2) reducing the concentration of PR proteins by fermentation with nonconventional yeasts, (3) reducing bentonite dose by exploiting complementary affinities of bentonite and other oenological agents towards PR proteins, and (4) investigation of the causes of high bentonite requirements of Malvazija istarska white wine. The research will be conducted through a series of technological experiments supported by a strong analytical platform comprising conventional instrumental analyses complemented by comprehensive proteomics and metabolomics, which are expected to generate cutting-edge novel data publishable in most reputable scientific journals. The solutions proposed are in line with the current legislative setting, are economically feasible and environmentally viable, do not include additional capital investments and labour, and could be readily commercially adopted. This would allow producers to obtain larger quantities of higher quality wine, and in this way strengthen their competitiveness on the market, which could have positive impact on the general quality of life in winemaking economies.]]></summary_en></project><project>
<id>14683</id><title_hr><![CDATA[Moždani izvanstanični matriks u razvitku i perinatalnoj hipoksiji]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6256</user_id><user_firstLast_name>Nataša Jovanov Milošević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-5988</code><acronim><![CDATA[BRAINECM]]></acronim><duration>01.11.2021 - 01.11.2025</duration><status>Prekinut</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>865159</team_members_id><team_members_names><![CDATA[ Doktorand: Matea Drlje ]]></team_members_names><keywords_hr><![CDATA[perineuronske mreže, interneuroni, razvojne fetalne zone, lektikani, MRI]]></keywords_hr><keywords_en><![CDATA[perineuronal nets, interneurons, devlopmental zones, lecticans, MRI]]></keywords_en><summary_hr><![CDATA[Unatoč dostignućima u razumijevanju važnosti neuralnog izvanstaničnog matriksa (ECM, difuznog ili kondenziranog kao perineuronske mreže - PNN) za fiziološke i patološke procese u mozgu, on je još uvijek daleko manje prepoznat i istražen od staničnih elemenata. U cilju novih spoznaja o ključnim molekulama i razvojnim događajima u ECM-u, posebno onih koji su izraženi u ljudskom mozgu, istraživači sa HIIM-a, Zagreba i Tehničkog Sveučilišta u Dresdenu,  sa kliničarima-istraživačima sa KBC Zagreb i AKH, Sveučilišta u Beču će ujediniti znanstvene pristupe, modele (ljudski, štakorski i organoidi) i metodologije (3T I 7T MRI, histološke, molekularne, bihevioralne) kako bi se odgovorilo na sljedeće znanstvene ciljeve: (1) otkriti značajne razlike u sastavnicama ECM-a između fetalnih zona, odjeljaka, aksonskih (strata) i kortikalnih (layers) slojeva; (2) otkriti obrasce ekspresije molekula ECM-a telencefaličke stjenke i bazalnih ganglija u razvitku; (3) definirati ključne vremenske točke ireverzibilnih promjena ekspresijskih obrasca ECM-a prijelazom u juvenilni oblik ECM-a; (4) otkriti korelate fetalnih ECM obrazaca na slikovnim prikazima MRI u zdravlju (humani i štakorski model) i nakon perinatalne hipoksije (štakorski model); (5) otkriti staničnu i prostorno vremensku distribuciju PNN-a i njihove molekularne značajke u razvitku i nakon perinatalne hipoksije (štakora); (6) i korelirati ih sa bihevioralnim posljedicama hipoksije. Očekujemo da će istraživanje omogućiti da procijenimo značaj i ulogu molekula, obrazaca i reorganizacijskih procesa moždanog ECM-a. Rezultati projekta biti će nove znanstvene spoznaje, publikacije, unapređenje edukacije i pozicioniranje za daljnje međunarodne projekte usmjerene na razvoj novih ECM-baziranih istraživanja, dijagnostičkih i terapijskih strategija za neurorazvojne poremećaje kao što su kognitivni deficit, epilepsija, autizam ili shizofrenija.]]></summary_hr><summary_en><![CDATA[Despite recent advances in the understanding of the importance of the neural extracellular matrix (ECM,  diffused or condensed as perineuronal nets, PNN) for physiological and pathological processes in the brain, it is still widely less recognized and researched than different neural cellular elements. To combat the lack of knowledge on key ECM players relevant for human brain development, basic researchers (at CIBR, Zagreb, and TU, Dresden) and clinical oriented researchers (at CHC Zagreb, AKH Vienna and TU Dresden) will unite scientific approaches, models (human, rat, and organoids) and methodologies (3T and 7T MRI, histological, molecular and behavioural), to address the following scientific aims: (1) to detect major differences in ECM constituents among the fetal brain zones, compartments, axonal strata, and cortical layers; (2) to disclose the different ECM expression patterns in the developing brain;  (3) to define the crucial time points of ECM expression patterns irreversible up-turns in transition to juvenile ECM form; (4) to reveal the correlates of the fetal ECM patterns in high-resolution MRI in health (human, rat) and after perinatal hypoxia (rat); (5) to disclose cellular and spatial-temporal distribution, and molecular determinants of the PNN in health (human and rat) and after perinatal hypoxia (rat); and  to correlate them to behavioural consequences of hypoxic ECM lesion (rat). These will enable us to evaluate the significance and the role of ECM constituents, and ECM reorganization, for the developmental processes (proliferation, migration, axon growth, folding, and synaptogenesis) in the human brain, in health and disorders. The outcome of the project will be new knowledge, publications, advances in education, and positioning for joint international proposals towards ECM-based research, diagnostic and therapeutic strategies, for neurodevelopmental disorders as cognitive disabilities, epilepsy, autism or schizophrenia.]]></summary_en></project><project>
<id>14685</id><title_hr><![CDATA[Coordinate - COhort cOmmunity Research and Development Infrastructure Network for Access Throughout Europe, Project ID: 101008589]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6293</user_id><user_firstLast_name>Toni Babarović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-4410</code><acronim><![CDATA[]]></acronim><duration>01.10.2021 - 30.09.2025</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Psihologija, </scie_field_hr><scie_field_en>Psychology, </scie_field_en><institution_hr><![CDATA[Institut društvenih znanosti Ivo Pilar]]></institution_hr><institution_en><![CDATA[Institute of Social Sciences Ivo Pilar in Zagreb]]></institution_en><team_members_id>865054</team_members_id><team_members_names><![CDATA[ Doktorand: Eta Krpanec ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>14686</id><title_hr><![CDATA[Razvoj metoda matematičkog modeliranja u biologiji i medicini]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3273</user_id><user_firstLast_name>Inga Urlić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-7662</code><acronim><![CDATA[MethMathModBioMed]]></acronim><duration>04.04.2022 - 03.04.2026</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>861499</team_members_id><team_members_names><![CDATA[ Doktorand: Karla Ostojić ]]></team_members_names><keywords_hr><![CDATA[difuzijski procesi, Markovljevi procesi, aproksimativni MLE, odabir modela, tumorski sferoidi, asimptotska distribucija, dizajn eksperimenta, telomeri]]></keywords_hr><keywords_en><![CDATA[diffusion processes, Markov processes, approximate MLE, model selection, tumor spheroids, asymptotic distribution, design of experiments, telomere]]></keywords_en><summary_hr><![CDATA[Iako su metode matematičkog modeliranja u biomedicine do sada znatno razvijene dosta je  problema koje još treba postaviti i riješiti matematički. Uobičajeno su ti problemi vezani uz istraživanje svojstava predloženog matematičkog modela, uz prilagodbu modela podacima i njegovog vrednovanja te upotrebe u biomedicini. Budući da su sve te faze u matematičkom modeliranju blisko vezane uz stvarne podatke i razumijevanje fenomena od interesa, posebno ćemo se fokusirati na tri problema: modeliranje rasta avaskularnih tumorskih sferoida, modeliranje skraćivanja telomera i modeliranje i procjenjivanje koreliranosti duljina telomera/aktivnosti telomeraze i stope rasta sferoida.  U modeliranju rasta sferoida planiramo proizvesti stvarne podatke, efikasno prilagoditi difuzijske procese rasta, izabrati najprihvatljiviji model i vrednovati ga. U tu svrhu moramo analizirati svojstva predloženih procjenitelja metodama stohastičke analize i matematičke statistike, koristiti metode primijenjene statistike za prilagodbu modela i vrednovanje, te dizajnirati i primijeniti testove za odabir modela i testiranje homogenosti sferoida. U modeliranju skraćivanja telomera planiramo odrediti i predložiti model baziran na difuzijama, analizirati razdiobe vremena iščeznuća telomera i stanica i dizajnirati statistički model za prilagodbu predloženog procesa skraćenja telomera. U tu svrhu koristi ćemo metode teorije slučajnih procesa, stohastičke analize i matematičke statistike. Teoremi koje planiramo dokazati su doprinosi u polju primijenjene matematike, posebno u primjeni slučajnih procesa, matematičkoj i primijenjenoj statistici.  Očekujemo da će ovo istraživanje imati utjecaja na poboljšanje predikcijskih modela za pacijente oboljele od raka, na primjenjivost sferoida u personaliziranoj medicini, te na razumijevanje procesa staničnog starenja.]]></summary_hr><summary_en><![CDATA[Although methods of mathematical modelling in biomedicine have been significantly developed so far still there are many problems that have to be addressed and solved mathematically.  These problems are usually related to research for properties of a proposed mathematical model, to fitting a model to data and its validation and use in biomedicine. Since all of these stages in mathematical modelling are closely related to real data and understanding of the phenomena of interest we will particularly focus on three problems: modelling of avascular tumour spheroid growth, modelling of telomere shortening, and modelling and estimating correlation of telomere length/telomerase activity and spheroid growth rate. In modelling tumour spheroids growth we plan to obtain real data, fit diffusion processes of growth efficiently, select the most acceptable model and validate it. For this purpose we need to analyse properties of proposed estimators by methods of stochastic analysis and mathematical statistics, to use applied statistics methodology for fitting model to data and its validation, and to design and apply tests for model selection and for testing homogeneity of spheroids. In modelling telomere shortening we plan to determine and propose diffusion based models, analyse distributions of telomere extinction time and cells, and design statistical model for fitting the proposed process of telomere shortening.  To do that we have to use methods of theory of random processes, stochastic analysis and mathematical statistics. Theorems that we plan to prove are improvements in the field of applied mathematics, particularly in application of random processes, mathematical and applied statistics. We expect that this research will have impacts on improving prediction models for cancer patients and applicability of tumour spheroids in personalized medicine, and in improving our understanding of cell aging processes.]]></summary_en></project><project>
<id>14687</id><title_hr><![CDATA[JERICO S3. Joint European Research Infrastructure of Coastal Observatories: Science, Service, Sustainability)]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3476</user_id><user_firstLast_name>Martin Pfannkuchen</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-5104</code><acronim><![CDATA[]]></acronim><duration>03.11.2021 - 02.11.2025</duration><status>Završio</status><financ_value>48,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>865127</team_members_id><team_members_names><![CDATA[ Doktorand: Lana Grižančić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>14688</id><title_hr><![CDATA[Osjetljivost komercijalno važnih školjkaša u akvakulturi istočnog dijela Jadrana na promjene okolišnih uvjeta ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>119</user_id><user_firstLast_name>Lorena Perić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-7567</code><acronim><![CDATA[BEST ADRIA]]></acronim><duration>20.10.2021 - 19.04.2026</duration><status>U tijeku</status><financ_value>54,00 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Interdisciplinarne biotehničke znanosti, </scie_field_hr><scie_field_en>Interdisciplinary biotechnical sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>865103</team_members_id><team_members_names><![CDATA[ Doktorand: Karla Orlić ]]></team_members_names><keywords_hr><![CDATA[akvakultura, školjkaši, stres, bakterije, istočni Jadran]]></keywords_hr><keywords_en><![CDATA[aquaculture, bivalves, stress, bacteria, eastern Adriatic]]></keywords_en><summary_hr><![CDATA[Komercijalna akvakultura mediteranske dagnje Mytilus galloprovincialis i europske plosnate kamenice Ostrea edulis prevladava na području istočnog Jadrana. Budući da se proizvodnja školjkaša tradicionalno odvija u in situ uvjetima, njihove odlike u potpunosti ovise o okolišnim uvjetima. Zbog navedenog razloga, uspješnost uzgoja školjkaša zahtijeva obuhvatnije znanje o čimbenicima koji mogu nepovoljno utjecati na kvalitetu krajnjeg proizvoda. Tipična obilježja obalnih područja Jadrana pogodnih za akvakulturu školjkaša su prostorna i vremenska heterogenost hidroloških uvjeta i razine hranjivih tvari, a u današnje vrijeme i sve veći rizik uvjetovan izlaganjem kemijskim zagađivalima dospjelih s kopna. Svi navedeni čimbenici, pojedinačno ili u sprezi, mogu potaknuti fiziološki stres školjkaša u uzgoju. Osim toga, zbog iznimno velike sposobnosti filtriranja školjkaši u velikoj mjeri nakupljaju mikroorganizme koji se nalaze u vodenom stupcu. Zbog učestale pojavnosti i abundancije u obalnim vodama, bakterije roda Vibrio izazivaju veliku pozornost. Epidemije uzrokovane izlaganjem patogenim vrstama vibrija u morskoj vodi i konzumacijom kontaminiranih školjkaša ili blago termički obrađenih od globalnog je javno zdravstvenog značaja. No, povezanost lokalnog okoliša sa mikrobnom zajednicom školjkaša u uzgoju istočne obale Jadrana je neostatno dokumentirana. Cilj predstavljenog istraživanja, temeljenog na in situ eksperimentu, je utvrditi kako lokalne promjene okolišnih uvjeta utječu na odlike školjkaša u uzgoju i posljedično na strukturu njihove mikrobne zajednice i podložnost kolonizaciji patogenih vrsta vibrija. Navedeni aspekt će biti od ključne važnosti za produktivnost i održivost akvakulture školjkaša u Jadranu, a naročito u svjetlu nepovoljnog učinka globalnih klimatskih promjena u sprezi sa sve intenzivnijim antropogenim pritiscima predviđenim u bliskoj budućnosti. ]]></summary_hr><summary_en><![CDATA[Commercial aquaculture of Mediterranean mussel Mytilus galloprovincialis and European flat oyster Ostrea edulis largely predominates in the eastern Adriatic. Since bivalve production is traditionally carried out in situ their performance is entirely dependent on environmental conditions. Therefore, the overall success of aquaculture practice requires improved understanding of factors that may negatively influence the quality and health of bivalve products. Adriatic coastal environments suitable for bivalve aquaculture typically display spatial and temporal heterogeneity of hydrological conditions and nutrients availability, and are nowadays increasingly threatened by exposure to chemical pollutants originating from adjacent land. All these factors may, alone or in combination, elicit physiological stress in farmed bivalves. Further, because of their extraordinary seawater filtering capacity, bivalves readily acquire microbes from water column. Among them, bacteria of the genus Vibrio have attracted particular interest given their abundance and ubiquity in coastal waters. In particular, diseases caused by exposure to pathogenic Vibrio species in water and consumption of contaminated raw or undercooked seafood have raised global public health concerns. In addition, interaction of local environment with microbial community associated to bivalves farmed in the eastern Adriatic aquaculture is apparently poorly documented. The aim of this field based project is to investigate how locally modulated environmental conditions affect the performance of farmed bivalves and consequently their microbial community composition and susceptibility to colonization by Vibrio pathogens. This aspect is of paramount importance for productivity and sustainability of bivalve aquaculture along the Adriatic, in particular in light of the negative impacts of global climate change in combination with more intense anthropogenic pressure foreseen in the near future.]]></summary_en></project><project>
<id>14689</id><title_hr><![CDATA[Izloženost piretroidnim i organofosfatnim insekticidima u djece - procjena rizika od štetnih učinaka na neuropsihološki razvoj i hormonski status]]></title_hr><title_en><![CDATA[]]></title_en><user_id>13074</user_id><user_firstLast_name>Adrijana Bjelajac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-7823</code><acronim><![CDATA[PyrOPECh]]></acronim><duration>13.09.2021 - 17.03.2026</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Psihologija, </scie_field_hr><scie_field_en>Psychology, </scie_field_en><institution_hr><![CDATA[Institut za medicinska istraživanja i medicinu rada]]></institution_hr><institution_en><![CDATA[Institute for Medical Research and Occupational Health]]></institution_en><team_members_id>865024</team_members_id><team_members_names><![CDATA[ Doktorand: Patricia Tomac ]]></team_members_names><keywords_hr><![CDATA[insekticidi, metaboliti pesticida u urinu, procjena izloženosti hranom, procjena rizika, neuropsihološki razvoj]]></keywords_hr><keywords_en><![CDATA[insecticides, biomonitoring, dietary exposure assessment, risk assessment, neuropsychological development, pubertal development]]></keywords_en><summary_hr><![CDATA[Epidemiološka istraživanja i pokusi na životinjama upućuju na moguće štetne učinke piretroidnih (PYR) i organofosfatnih (OP) insekticida na razvoj mozga i spolni razvoj u djece, čak i pri vrlo niskim razinama izloženosti. Međutim, moguća povezanost izloženosti pesticidima s navedenim zdravstvenim parametrima malo je istraživana za razdoblje puberteta, uz nejednoznačne rezultate i znatna metodološka ograničenja, kao što su nedovoljno definirana izloženost i presječni dizajn studija.   Glavni cilj predloženog projekta je procijeniti rizik od štetnih učinaka izloženosti PYR i OP insekticidima na neuropsihološki razvoj i hormonski status dječaka u predpubertetu i pubertetu u 2-godišnjoj kohortnoj studiji, uz kontrolu za potencijalne čimbenike utjecaja, koristeći isključivo neinvazivne metode. Izloženost djece PYR i OP insekticidima procjenjivat će mjerenjem njihovih metabolita u urinu u 5. i 7. razredu osnovne škole, te procjenom unosa pesticida hranom pomoću 24-satnog prisjećanja o prehrani u pet navrata tijekom 2-godišnjeg praćenja. U 5. i 7. razredu osnovne škole procjenjivat će se neuropsihološki razvoj testiranjem pažnje, pamćenja i brzine jednostavne psihomotorne reakcije, procjenom karakteristika spavanja i neurobihevioralnog funkcioniranja, a pubertetski razvoj procjenjivat će se pomoću kliničkog pregleda (po Tanneru i Praderu), mjerenja gonadotropina u urinu te spolnih hormona (testosterona i dehidroepiandrosteron sulfata) u slini.  Očekuje se da će istraživanje doprinijeti 1) razumijevanju rizika od mogućih štetnih učinaka PYR i OP insekticida na neuropsihološki razvoj i hormonski status dječaka u pubertetu; 2) prepoznavanju nedostataka i unaprjeđenju danas raspoložive metodologije ocjenjivanja razvojne neurotoksičnosti i endokrine disrupcije u okviru regulatorne toksikologije; 3) razvoju metodologije za procjenu izloženosti pesticidima koji nemaju osobinu nakupljanja u tijelu; 4) boljoj karakterizaciji izloženosti pesticidima u hrvatskoj populaciji.  ]]></summary_hr><summary_en><![CDATA[Epidemiological studies and animal experiments indicate the potential adverse effects of exposure to pyrethroid (PYR) and organophosphate (OP) insecticides on brain and sexual development in children, even at very low exposure levels. However, limited number of studies explored these potential risks during puberty, with inconsistent results and significant methodological limitations, such as insufficiently assessed exposure and cross-sectional study design.The main objective of the proposed research is to assess the risk of PYR and OP insecticide exposure to neuropsychological development and hormonal status in prepubertal and pubertal boys in a 2-year cohort study, while controlling for potential confounders, and using only non-invasive methods.Children’s exposure to PYR and OP insecticides will be assessed by biomonitoring (analysing urinary pesticide metabolites) in the 5th and 7th grades of elementary school, and by dietary exposure assessment - 24-hour dietary recall on five occasions during 2-year follow-up. In the 5th and 7th grades, neuropsychological development will be evaluated by testing attention, memory and simple psychomotor response speed, and by assessing the characteristics of child’s sleep and behaviour. Pubertal development will be evaluated by clinical examination (according to Tanner and Prader), and urinary gonadotropins and salivary sex hormones (testosterone and dehydroepiandrosterone sulfate) measurements. The research is expected to 1) increase the knowledge on possible risks of PYR and OP insecticides’ exposure for neurodevelopment and hormonal status in pubertal boys; 2) help to recognise deficiencies and assess available methodology for evaluation of developmental neurotoxicity and endocrine disruption within the framework of regulatory toxicology; 3) improve insufficient methodology for exposure assessment of non-bioaccumulative pesticides; 4) contribute to the better characterisation of pesticide exposure in the Croatian population.]]></summary_en></project><project>
<id>14690</id><title_hr><![CDATA[Centar kompetencija Trilj CEKOM 3LJ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6452</user_id><user_firstLast_name>Marin Čagalj</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-4205</code><acronim><![CDATA[]]></acronim><duration>01.09.2021 - 01.09.2025</duration><status>Prekinut</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Institut za jadranske kulture i melioraciju krša]]></institution_hr><institution_en><![CDATA[Institute for Adriatic Crops and Karst Reclamation in Split]]></institution_en><team_members_id>865104</team_members_id><team_members_names><![CDATA[ Doktorand: Željan Dulčić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>14692</id><title_hr><![CDATA[Odgovori na antisocijalne osobnosti u demokratskom društvu ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4172</user_id><user_firstLast_name>Marko Jurjako</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-2681</code><acronim><![CDATA[RAD]]></acronim><duration>09.12.2021 - 09.03.2026</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filozofija, </scie_field_hr><scie_field_en>Philosophy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Filozofski fakultet u Rijeci]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>865224</team_members_id><team_members_names><![CDATA[ Doktorand: Mladen Bošnjak ]]></team_members_names><keywords_hr><![CDATA[Neuroetika, psihijatrijska etika, antisocijalni poremećaj ličnosti, psihopatija, neuropsihologija, pučka psihologija, liječenje, moralno poboljšanje,]]></keywords_hr><keywords_en><![CDATA[Neuroethics, psychiatric ethics, antisocial personality disorder, psychopathy, treatment, moral enhancement, neuropsychology, folk psychology, ]]></keywords_en><summary_hr><![CDATA[Predloženi istraživački projekt istražit će etička pitanja koja se javljaju pri prevođenju i prenošenju znanstvenih spoznaja o antisocijalnim osobnostima na društvene prakse unutar demokratskog društva. Cilj je povezati ili sučeliti najznačajnije rezultate trenutno dostupnih znanstvenih spoznaja o antisocijalnom ponašanju s normativnim okvirom koji bi trebao potkrijepiti etičke preporuke o liječenju, intervenciji, poboljšanju i prevenciji kriminalaca i drugih osoba s tim poremećajima. U fokusu istraživanja se nalaze dva općenita i hitna teorijska izazova. Jedan je problem povezivanja ili sučeljavanja normativnog pojma osobe i njezinih kognitivnih moći i sposobnosti za odlučivanje sa znanstvenim koncepcijama i spoznajama o tim sposobnostima. Normativni pojam osobe se elaborira u filozofskim i pravnim teorijama kriminalne i moralne odgovornosti koje podrazumijevaju postojanje sposobnosti za racionalno odlučivanje i autonomiju. Drugi je problem artikuliranje normativnog okvira za primjenu na dva međusobno povezana normativna zadatka. Prvo, ovaj okvir mora dati formu opravdanja za pojam normativne osobe koji sam ne smije biti obilježen spornim metafizičkim gledištima već mora biti definiran u terminima koji su prihvatljivi unutar pluralističkog i demokratskog društva. Drugo, normativni okvir mora nas voditi prema praktičnim rješenjima o tome kako reagirati na pojedince s antisocijalnim poremećajima osobnosti, koja mogu biti prihvatljiva svim racionalnim članovima pluralističkog i demokratskog društva. ]]></summary_hr><summary_en><![CDATA[The proposed research project will investigate the ethical issues raised by translating scientific advances in the study of antisocial personalities to the social practices of a democratic society. The aim is to interface the most remarkable results of current science of antisocial behaviour with a normative framework that should underpin ethical recommendations on the treatment, intervention, enhancement and prevention that target offenders and other individuals with these disorders.Two general and pressing theoretical challenges will be at the core of the proposed investigation. One is the problem of interfacing the normative notion of a person and her cognitive and decision-making faculties with scientific conceptions of those faculties. The normative notion of a person is spelled out in philosophical and legal accounts of criminal and moral responsibility that presuppose having capacities for rational decision-making and autonomy. The other is the problem of articulating a normative framework for applying it to two interrelated normative tasks. First, this framework must inform the justification of a notion of the normative person that, being not hostage to metaphysically contestable views, is acceptable within a pluralistic democratic society. Second, it would guide our practical resolutions about how to respond to individuals with antisocial personalities that is viable in a pluralistic democratic society.]]></summary_en></project><project>
<id>14693</id><title_hr><![CDATA[Onečišćenje zraka i biomarkeri učinka u ljudi]]></title_hr><title_en><![CDATA[]]></title_en><user_id>171</user_id><user_firstLast_name>Marko Gerić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-4397</code><acronim><![CDATA[]]></acronim><duration>13.09.2021 - 13.03.2026</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut za medicinska istraživanja i medicinu rada]]></institution_hr><institution_en><![CDATA[Institute for Medical Research and Occupational Health]]></institution_en><team_members_id>865031</team_members_id><team_members_names><![CDATA[ Doktorand: Katarina Matković ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>14694</id><title_hr><![CDATA[HRZZ projekt: Numerička procjena rizika od rupture nekomplicirane disekcije aorte tipa B (postpisivanje ugovora je u tijeku)]]></title_hr><title_en><![CDATA[]]></title_en><user_id>7644</user_id><user_firstLast_name>Željko Tuković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-3071</code><acronim><![CDATA[]]></acronim><duration>01.10.2021 - 01.04.2026</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, </scie_field_hr><scie_field_en>Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>865138</team_members_id><team_members_names><![CDATA[ Doktorand: Anja Horvat ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>14697</id><title_hr><![CDATA[CoAStal and marine waters integrated monitoring systems for ecosystems  proteCtion AnD managemEnt (CASCADE)]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3130</user_id><user_firstLast_name>Ivana Ujević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-7058</code><acronim><![CDATA[]]></acronim><duration>01.10.2021 - 02.04.2026</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Interdisciplinarne prirodne znanosti, </scie_field_hr><scie_field_en>Interdisciplinary natural sciences, </scie_field_en><institution_hr><![CDATA[Institut za oceanografiju i ribarstvo]]></institution_hr><institution_en><![CDATA[Institute of Oceanography and Fisheries]]></institution_en><team_members_id>862776</team_members_id><team_members_names><![CDATA[ Doktorand: Antonija Bulić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>14700</id><title_hr><![CDATA[Utjecaj različitih vinifikacijskih tehnologija na kvalitativna svojstva vina od autohtonih hrvatskih sorti: uloga vina u ljudskoj prehrani]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6511</user_id><user_firstLast_name>Sanja Radeka</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-6937</code><acronim><![CDATA[VINUM SANUM]]></acronim><duration>23.08.2021 - 20.11.2025</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Institut za poljoprivredu i turizam]]></institution_hr><institution_en><![CDATA[Institute of Agriculture and Tourism in Poreč]]></institution_en><team_members_id>865018</team_members_id><team_members_names><![CDATA[ Doktorand: Fumica Orbanić ]]></team_members_names><keywords_hr><![CDATA[vino, vinifikacijske tehnologije, polifenoli, antioksidanti, ljudsko zdravlje]]></keywords_hr><keywords_en><![CDATA[wine, vinification technology, polyphenols, antioxidants, human health]]></keywords_en><summary_hr><![CDATA[Postoji veliki nedostatak objektivnih spoznaja o utjecaju primjene različitih vinifikacijskih tehnologija na kvalitativna svojstva vina od hrvatskih autohtonih bijelih  crnih sorti vinove loze, te njihove uloge u ljudskoj prehrani. Cilj ovog projekta je utvrditi razlike između kvalitativnih svojstava mladih (svježih) i zrelih (odležalih) vina gospodarski najvažnijih hrvatskih autohtonih bijelih i crnih sorti vinove loze (Malvazija istarska, Teran, Pošip i Plavac mali), proizvedenih različitim tehnologijama vinifikacije (kao što su standardna „brza prerada“ bez maceracije masulja, sa dodatkom i bez dodatka enoloških tanina, kratkotrajna, predfermentativna (crio) maceracija, dugotrajna, postfermentativna maceracija masulja i odležavanje vina u drvenim bačvama), te utjecaj njihove umjerene, kontrolirane konzumacije na psiho-fizičko zdravlje skupina ispitanika uključenih u istraživanje. Proizvedena vina biti će podvrgnuta detaljnoj analizi osnovnog fizikalno-kemijskog sastava, sastava hlapljivih armatskih spojeva, fenolnih spojeva, antioksidacijskog potencijala i nutritivnih svojstva, te će vina biti i senzorno ocjenjena. Posebna pozornost posvetit će se istraživanju spojeva zaslužnih za biološku aktivnost vina i njegovu pozitivnu ulogu u ljudskoj prehrani. Skupine ispitanika uklučene u istraživanje biti će podvrgnute kontroliranoj umjerenoj konzumaciji bijelih i crnih vina, proizvedenih specifičnim tehnologijama, u trajanju od 1-3 mjeseca, te će im se redovito kontrolirati zdravstveni parametri (tlak, šećer, kolesterol LDL, HDL, hormoni „sreće“ itd.). Također ispitanici će biti anketirani, prema unaprijed razrađenim anketnim upitnicima, o razini raspoloženja prije i nakon umjerene konzumacije vina. ]]></summary_hr><summary_en><![CDATA[There is a great lack of objective knowledge of the influence of the use of different vinification technologies on the qualitative properties of wines produced from Croatian autochthonous white grape varieties of vines and their role in human nutrition. The aim of this project is to determine the differences between the qualitative characteristics of young (fresh) and mature (aged) wines of the most important Croatian autochthonous white and black grape varieties (Malvazija istarska, Teran, Pošip and Plavac mali) produced by various vinification technologies (such as standard &#39;&#39;rapid processing&#39;&#39; without maceration of the grape mash, with addition and without the addition of oenological tannins, short-term pre-fermentation (cryo) maceration, long-lasting, post fermentative maceration and maturation of wine in wooden barrels), and the influence of moderate, controlled consumption of wine on the psychophysical health of surveyed groups. Produced wines will be subjected to a detailed analysis of the basic physical-chemical composition, volatile compounds, phenolic compounds, antioxidant potential and nutritional properties, and the wines will be sensoricaly evaluated. Particular attention will be paid to the research of compounds responsible for the bioactivity of wine and its positive role in human diet. The groups of participants surveyed will be subjected to controlled moderate consumption of white and black wines produced by specific technologies for 1-3 months and human health parameters will be regularly monitored (blood pressure, sugar, LDL cholesterol, HDL, &#39;&#39;happiness hormones&#39;&#39;, etc.). Also, participants will be interviewed, according to pre-elaborated questionnaires, about the psychological state before and after moderate consumption of wine.]]></summary_en></project><project>
<id>14701</id><title_hr><![CDATA[Fotonsko sinteriranje inkjet ispisanih elektrokemijskih senzora i biosenzora na plastičnim podlogama]]></title_hr><title_en><![CDATA[]]></title_en><user_id>24859</user_id><user_firstLast_name>Petar Kassal</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-2362</code><acronim><![CDATA[PrintEChemSens]]></acronim><duration>26.10.2021 - 25.10.2025</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet kemijskog inženjerstva i tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Chemical Engineering and Technology]]></institution_en><team_members_id>865194</team_members_id><team_members_names><![CDATA[ Doktorand: Marko Zubak ]]></team_members_names><keywords_hr><![CDATA[Elektrokemijski senzori, Biosenzori, Inkjet senzori, Printana elektronika, Fotonsko sinteriranje, Nosivi senzori, mikrofluidika, Lab-on-a-Chip]]></keywords_hr><keywords_en><![CDATA[Electrochemical sensors, Biosensors, Inkjet printed sensors, Printed electronics,  Photonic sintering, Wearable sensors, microfluidics, Lab-on-a-Chip]]></keywords_en><summary_hr><![CDATA[Rasprostranjenost elektrokemijskih (bio)senzora potrebna je kako bi se riješila goruća globalna pitanja, primarno iz područja zdravstva i zaštite okoliša. Širenje senzora trenutno usporava nedostatak jeftinih i brzih proizvodnih tehnologija, ali to se može riješiti primjenom provjerenih tehnologija iz područja printane elektronike. Konkretno, inkjet ispis je prilagodljiva i jeftina tehnologija kompatibilna s masovnom proizvodnjom koja omogućava izradu cijelih (bio)kemijskih senzora uz manje otpada. Glavni cilj ovog projektnog prijedloga je uspostava neovisne istraživačke grupe fokusirane na razvoj inkjet ispisanih elektrokemijskih senzora i biosenzora. Istraživanje tijekom projekta provodit će se od sinteze vodljivih tinti temeljenih na nanočesticama metala (Au, Ag, Cu) i ugljika (ugljikove nanocjevčice, grafen, grafen-oksid) ili vodljivim polimerima, do razvoja planarnih čvrstih ion selektivnih elektroda i amperometrijskih biosenzora inkjet ispisom.  Kako bismo unaprijedili razvoj, koristit ćemo fotonsko sinteriranje te ćemo razjasniti utjecaj te tehnologije na morofološka i električna svojstva nanočestica, kao i na analitičku izvedbu novih senzora. Tijekom projekta, razvit ćemo na plastičnim podlogama jeftine ali robusne senzore za određivanje važnih analita u nosivim sustavima  za analizu znoja (elektroliti) te ključnih analita u zaštiti okoliša (farmaceutici i pesticidi). Naposljetku, integrirat ćemo razvijeni inkjet ispis senzora s 3D tiskanjem mikrofluidičkih uređaja kako bismo razvili visoko integrirane printane Lab-on-a-Chip uređaje.  Kroz efektivnu diseminaciju i suradnju osigurat ćemo znatan utjecaj projekta, olakšati prodore u druga srodna područja printane elektronike i pronaći izvore vanjskog financiranja te na taj način omogućiti nastavak istraživačkih aktivnosti grupe i nakon završetka projekta. ]]></summary_hr><summary_en><![CDATA[Widespread distribution of electrochemical (bio)sensors is needed to solve pressing  global challenges in different areas, particularly healthcare and environmental monitoring. Their propagation is currently hindered by a lack of  high throughput, cost-effective fabrication of electrochemical sensing devices, but this can be solved by employing established technologies from printed electronics. Specifically, inkjet printing is a highly versatile, scalable and low-cost fabrication technology, which enables development of entire (bio)chemical sensors with less waste. The main goal of this project proposal is establishment of an independent research group working on the development of inkjet-printed electrochemical sensors and biosensors. Research during the project will be conducted from the  synthesis of conductive inks based on metal (Au, Ag, Cu) and carbon (carbon nanotube, graphene, graphene-oxide) nanoparticles or conducting polymers, to the development of planar solid state ion-selective electrodes and amperometric biosensors by inkjet printing. To improve this development, we will employ photonic sintering and elucidate its effects on nanoparticle morphological and electrical characteristics and on the analytical performance of novel sensors. During the project, we will develop low-cost but robust sensors on plastic substrates, for the detection of important analytes in wearable sweat sensing (electrolytes) and environmental protection (drugs and pesticides). Ultimately, we will integrate inkjet printing of sensors with 3D-printed microfluidics to develop  all-printed highly integrated Lab-on-a-Chip devices. Through effective dissemination and collaboration, we will ensure substantial impact of the project , facilitate breakthroughs into other related areas of printed electronics, and acquire additional funding, thus enabling continuation of the group&#39;s research activities beyond the project&#39;s end.]]></summary_en></project><project>
<id>14703</id><title_hr><![CDATA[Unaprjeđenje tehnologije visokoučinskog zavarivanja, KK.01.1.1.07.0076]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5040</user_id><user_firstLast_name>Milan Vujanović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-4582</code><acronim><![CDATA[]]></acronim><duration>01.12.2021 - 31.05.2026</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, </scie_field_hr><scie_field_en>Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>865252</team_members_id><team_members_names><![CDATA[ Doktorand: Marijan Marković ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>14704</id><title_hr><![CDATA[Uloga ličnosti,  motivacije i socio-emocionalnih kompetencija u profesionalnoj dobrobiti učitelja u ranoj fazi karijere]]></title_hr><title_en><![CDATA[]]></title_en><user_id>7765</user_id><user_firstLast_name>Iris Marušić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-2915</code><acronim><![CDATA[]]></acronim><duration>04.10.2021 - 03.10.2025</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Psihologija, </scie_field_hr><scie_field_en>Psychology, </scie_field_en><institution_hr><![CDATA[Institut za društvena istraživanja]]></institution_hr><institution_en><![CDATA[Institute for Social Research in Zagreb]]></institution_en><team_members_id>865026</team_members_id><team_members_names><![CDATA[ Doktorand: Dora Petrović ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>14705</id><title_hr><![CDATA[Transormacija robota u edukacijsko sredstvo]]></title_hr><title_en><![CDATA[]]></title_en><user_id>22784</user_id><user_firstLast_name>Kristina Cergol</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-3414</code><acronim><![CDATA[TRES]]></acronim><duration>13.10.2021 - 12.10.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filologija, </scie_field_hr><scie_field_en>Philology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Učiteljski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Teacher Education]]></institution_en><team_members_id>865176</team_members_id><team_members_names><![CDATA[ Doktorand: Valentina Gučec Gučec ]]></team_members_names><keywords_hr><![CDATA[edukacijski robot, analitika učenja, obrada video signala, otkrivanje znanja u skupovima podataka, edukacijsko sredstvo, nastavni materijali]]></keywords_hr><keywords_en><![CDATA[educational robot, learning analytics, video processing, data mining, educational tool, learning materials]]></keywords_en><summary_hr><![CDATA[Današnji trend je korištenje velikog broja elektroničkih uređaja u razredu: pametne ploče, prezentacije, Internet, edukacijski roboti. Iz mnoštva uređaja i informacija, teško je odrediti pomažu li oni uopće u poučavanju. Mnoge aktivnosti se upravo svode na njihovo korištenje, a ne na iskorištavanje njihovih prednosti s ciljem poučavanja. Predloženi projekt će razviti metodologiju evaluacije korištenja edukacijskih robota u poučavanju osnovnoškolskih predmeta. Pri tome će se uzeti u obzir postignuta razina znanja, ali i zadovoljstvo učenika za vrijeme i nakon održanog sata. Dodatno, roboti će se koristiti za identifikaciju individualne strategije učenja svakog učenika. Na temelju razvijene metodologije i eksperimentalnih rezultata, napravit će se usporedna analiza edukacijskih robota koji postoje na tržištu. Kako bi se postigli ciljevi projekta koristit će se analitički podaci koje je moguće prikupiti iz samih robota i njihovih programskih okruženja za vrijeme njihove upotrebe. Razvit će se algoritmi obrade prikupljenih informacija, njihova analiza, evaluacija i vizualizacija. Predložit će se prototip sustava koji uključuje unaprijeđene edukacijske robote, individualnu strategiju učenja učenika i nastavne materijale, a sa ciljem postizanja maksimuma znanja i uz maksimalno ugodan proces učenja. Istraživači okupljeni u istraživačku grupu su iskusni u dizajniranju, programiranju i korištenju edukacijskih robota, u razvoju metodologije istraživanja, u radi s učenicima osnovnih škola, te u otkrivanju znanja u skupovima podataka i u razvoju metoda znanosti o podacima.]]></summary_hr><summary_en><![CDATA[Today&#39;s trend is to use a number of electronic devices during the class: smart boards, presentations, the Internet, educational robots. From a plenty of devices and information, it is difficult to determine do they help or not in teaching pupils. Many activities are just about how to use the devices, and not to exploit their strengths in the teaching process. Proposed project will develop methodology for evaluation of the usage of educational robots in teaching primary school subjects. The methodology will consider the level of knowledge as well as learners’ satisfaction during and after the lessons. Additionally, the robots will be used for identification of individual learning strategies. Based on the developed methodology and experimental results, comparison of the state-of-the-art educational robots will be made. To achieve the project goals, analytic data will be collected from the logs of the educational robots and their programming environments. Algorithms for processing of the collected data, their analysis, evaluation and visualization will be developed. Finally, a prototype of a system, that includes the improved educational robots, the individual learning strategies and teaching materials will be proposed. The aim of the prototype is to achieve the maximum of the knowledge through a satisfying learning process. Researchers gathered in the research group have experience in designing, programming and using educational robots, in developing research methodologies, in field work with pupils, and in data mining and data science methods.]]></summary_en></project><project>
<id>14706</id><title_hr><![CDATA[Prapovijesni lovci i sakupljači u Istri i obližnjim regijama: obrasci života tijekom kasnog pleistocena ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>2764</user_id><user_firstLast_name>Ivor Janković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-3866</code><acronim><![CDATA[PREHISTRIA]]></acronim><duration>01.12.2021 - 30.11.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Arheologija, </scie_field_hr><scie_field_en>Archeology, </scie_field_en><institution_hr><![CDATA[Institut za antropologiju]]></institution_hr><institution_en><![CDATA[Institute for Anthropological Research]]></institution_en><team_members_id>864947</team_members_id><team_members_names><![CDATA[ Doktorand: Lia Vidas ]]></team_members_names><keywords_hr><![CDATA[pleistocen, paleolitik,prapovijest, litička analiza, Istra]]></keywords_hr><keywords_en><![CDATA[Pleistocene, Palaeolithic, Prehisstory, Lithic analysis, Istria]]></keywords_en><summary_hr><![CDATA[Glavni ciljevi projekta Prapovijesni lovci i sakupljači u Istri i obližnjim regijama: obrasci života tijekom kasnog pleistocena (PREHISTRIA) su dobiti bolji i detaljniji uvid u aspekte ponašanja gornjopaleolitičkih stanovnika Istre; usporediti ove prilagodbe u vremenskim (kronološkim) i prostornim (geografskim) dimenzijama; diseminirati rezultate istraživanja i tako stvoriti dobru osnovu za daljnje komparativne studije gornjeg paleolitika u široj geografskoj regiji, te podići javnu svijest o važnosti lokalnog arheološkog naslijeđa, posebice gornjopaleolitičkih nalazišta u Istri. Navedene ciljeve postići ćemo putem interdisciplinarnih istraživanja i pristupa, uključujući: 1. arheološka istraživanja na dva nalazišta na kojima su pronađeni pokazatelji ljudskog prisustva u radoblju gornjeg paleolitika (Abri Kontija 002 i Ljubićeva pećina, oba u Istri), 2. detaljne analize arheoloških nalaza s navedenih, kao i još nekoliko nalazišta s prostora Istre (Romualdova Pećina, Pupićina peć i Šandalja II) i nalazišta s prostora Italije (Grotta del Broion, Riparo Broion, Grotta Paina, Grotta Fiumane, Grotta Rio Secco, Ponte di Pietra, Grotta Trene, and Riparo Tagliente), 3. Usporedbu s ranije obljavljenim resultatima analiza relevantnih lokaliteta u obližnjim prostorima (npr. Dalmacija, Bosna i Hercegovina i dr.), 4. kroz aktivni pristup promicanju spoznaja o važnosti arheološke građe i lokaliteta u javnosti.]]></summary_hr><summary_en><![CDATA[The main objectives of the proposed project are: to: 1.get a better and more detailed insight into behavioural aspects of the Upper Palaeolithic inhabitants of Istria; 2. to compare these aspects and adaptations in both temporal (chronological) and spatial (geographic) dimensions; 3. to disseminate results of the research and thus create a good basis for further comparative studies on the Upper Palaeolithic in a wider geographical region, and to raise public awareness of the importance of local archaeological heritage. We will address these aims through a combination of: 1. fieldwork at two sites that yielded evidence of human occupation during the Upper Palaeolithic (Abri Kontija 002, and Ljubićeva pećina in Istria), 2. detailed analysis of finds from the excavations, and from several additional sites in Istria (Romualdova pećina, Pupićina peć, and Šandalja II) and relevant sites in Italy (Grotta del Broion, Riparo Broion, Grotta Paina, Grotta Fiumane, Grotta Rio appropriate Upper Palaeolithic sites in adjacent regions (e.g. Bosnia and Herzegovina, Dalmatia etc.), and 4. through an active engagement with and dissemination of knowledge to public audiences. ]]></summary_en></project><project>
<id>14707</id><title_hr><![CDATA[Procjena otpuštanja čestica mikroplastike iz poliesterskih tekstilija u procesu pranja]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4810</user_id><user_firstLast_name>Tihana Dekanić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-6750</code><acronim><![CDATA[InWaShed-MP]]></acronim><duration>08.11.2021 - 07.11.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Tekstilna tehnologija, </scie_field_hr><scie_field_en>Textile technology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Tekstilno-tehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Textile Technology]]></institution_en><team_members_id>865199</team_members_id><team_members_names><![CDATA[ Doktorand: Ana Šaravanja ]]></team_members_names><keywords_hr><![CDATA[poliesterske tekstilije, proces pranja, postepeno hlađenje kupelji, mikroplastika, kitozan, obrada tkanine]]></keywords_hr><keywords_en><![CDATA[polyester textiles, washing process, Cool down, microplastic, chitozan, finishing]]></keywords_en><summary_hr><![CDATA[U sklopu ovog projekta provjerit će se koncept inovativnog procesa pranja i značaj obrade poliesterskih (PES) tekstilija biopolimerom kitozanom u procjeni otpuštanja MP čestica u pranju. Inovativan proces pranja uključit će postepeno hlađenje procesne kupelji gradijentnom brzinom manjom od 4°C/minuti, a obrada poliesterskih tkanina i pletiva  provest će se kitozanom. Neobrađene i kitozanom obrađene PES tekstilije prije i nakon provedbe standardnog i inovativnog procesa pranja analizirat će se fizikalno-kemijskim metodama. Dobiveni podaci zajedno sa svim rezultatima karakterizacije voda nakon pranja i ispiranja, filtrata i filtarskog kolača nakon filtracije činit će matricu podataka na osnovi koje će se provesti multivarijantna analiza podataka (MVA). Rezultati analize strukturirat će se kroz portfolio standardnog i inovativnog procesa pranja za svaku od neobrađenih i biopolimerima obrađenih poliesterskih tkanina i pletiva. Na osnovi sadržaja portfolia će se dobiti uvid u kvalitativne i kvantitativne karakteristike otpuštenih čestica, te primjenjivost pojedine metode karakterizacije.]]></summary_hr><summary_en><![CDATA[The impact of innovative washing process and the modification of polyester (PES) textiles with biopolymer chitosan on microplastic (MP) shedding will be assessed though the project plan. Innovative washing process will be designed through Cool down system with gradient lower than 4°C/min. Polyester fabrics and knits will be modified with chitosan. Unmodified and biopolymer modified fabrics and knits will be characterized by physico-chemical methods before and after standard and innovative washing process. The obtained results of polyester textiles characterization and the results of process water, filtrate and filter cake analysis will constitute a data matrix to be used in multivariate data analysis (MVA). Investigation results will be structured in a portfolio of conventional and innovative washing process for each of the untreated polyester fabrics and knits and those treated with chitosan. The portfolio content will offer insight into qualitative and quantitative characteristics of MP shedded, as well as the applicability of each individual method of characterisation. ]]></summary_en></project><project>
<id>14708</id><title_hr><![CDATA[Mehanizmi nutrijentom posredovanih učinaka endogenog glukagonu sličnog peptida-1 na kognitivne i metaboličke poremećaje u eksperimentalnim modelima neurodegenerativnih bolesti]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1198</user_id><user_firstLast_name>Melita Šalković-Petrišić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-6419</code><acronim><![CDATA[NutrientGLP-1]]></acronim><duration>01.11.2021 - 01.11.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>861481</team_members_id><team_members_names><![CDATA[ Doktorand: Davor Virag ]]></team_members_names><keywords_hr><![CDATA[glukagonu sličan peptid-1, galaktoza, Alzheimerova bolest, Parkinsonova bolest, streptozotocin, 6-OHDA, kognitivne funkcije]]></keywords_hr><keywords_en><![CDATA[glucagone-like peptide -1, galactose, Alzheimer disease, Parkinson disease, streptozotocin, 6-OHDA, cognition]]></keywords_en><summary_hr><![CDATA[Projekt nastavlja prethodna istraživanja učinaka oralne galaktoze u eksperimentalnoj Alzheimerovoj bolesti (AB) putem detaljne karakterizacije mehanizama terapijskog učinka paralelno u eksperimentalnoj AB i Parkinsonovoj bolesti (PB). Rezultati aktualnog projekta podupiru naše preliminarne rezultate i upućuju da oralne galaktoza ublažava/normalizira kognitivna oštećenja u ranoj patološkoj fazi eksperimentalne sporadične AB (sAB) izazvane intracerebroventrikularnom primjenom streptozotocina u štakora (STZ-icv model). Ovo istraživanje će objediniti dva nova terapijska pristupa u liječenju neurodegenerativnih bolesti, temeljena na glukagonu-sličnom peptidu-1 (GLP-1) i nutrijentima. U netransgeničnim, toksinom izazvanim štakorskim modelima (sAB/STZ-icv model, PB/6-hidroksidopamin, 6-OHDA model) istražit će se učinak endogenog GLP-1 posredovan primjenom oralne galaktoze/nutrijenta. Cilj ovog 4-godišnjeg projekta je ispitati jesu li akutni metabolički/neuroprotektivni učinci jedne doze oralne galaktoze u sAB modelu posredovani samo endogenim GLP-1 ili/i endogenim glukoza-ovisnim inzulinotropnim peptidom (GIP). Također, cilj je ispitati je li terapijski potencijal dugotrajne primjene oralne galaktoze na kognitivna oštećenja, metaboličke i neuropatološke poremećaje u sAB i PB modelima povezan primarno s kompleksnim učincima galaktoze (izravni + inkretinima posredovani učinci) ili se radi samo o inkretinom posredovanim učincima. U 5 akutnih+5 kroničnih pokusa ispitat će se kognitivne i motorne funkcije, te poremećaji homeostaze glukoze/inzulina, te glavna neuropatološka sAB/PB obilježja i parametri signalizacije GLP-1/GIP/inzulina. Projekt će donijeti nove spoznaje i razviti specifični oblik modela-načina liječenja koji nalikuje mogućoj etiopatogenezi ovih bolesti u stvarnom životu.  Rezultati će pridonijeti pojašnjenju terapijskog pristupa sAB/PB temeljenog na GLP-1 lijekovima, a očekivane publikacije povećati kompetitivnost mladih istraživača za buduće projektne prijave. ]]></summary_hr><summary_en><![CDATA[This project aims to continue previous research on oral galactose treatment in experimental Alzheimer’s disease (AD) by in parallel characterizing in depth mechanisms of its therapeutic activity in experimental AD and Parkinson disease (PD). The results of on-going research supported our preliminary data and demonstrated that in the streptozotocin (STZicv)-induced rat model of sAD, oral galactose ameliorates or normalizes cognitive impairment in the early stage of sAD pathology.  By combining glucagon-like peptide-1 (GLP-1)-related and nutrient-based trends in accomplishing desirable neuroprotective effects in the treatment of neurodegenerative disorder, this research will explore oral galactose (nutrient)-promoted activity of endogenous GLP-1 in non-transgenic rat models of toxin-induced sporadic AD (sAD/STZ-icv model) and PD (6-hydroxydopamine, 6-OHDA model). This 4-year project aims to explore whether acute metabolic/neuroprotective effects of a single oral galactose dose in sAD model are mediated by promotion of solely endogenous GLP-1 or/and by endogenous glucose-dependent insulinotropic peptide (GIP), and whether the therapeutic potential of chronic oral galactose treatment on cognitive deficits, metabolic dysfunction and neuropathology in STZ-icv and 6-OHDA models results primarily from the complex galactose-induced effects (direct + incretin-mediated ones) or it is solely the incretin-mediated effect. Cognitive and motor performance and glucose/insulin homeostasis will be explored in 5 acute and 5 chronic experiments accompanied by AD-/PD-neuropathological hallmarks as well as GLP-1/GIP/insulin signalling assessment.  Project will gain new knowledge and establish the specific model-treatment design that mimics more closely the real life situation. The results will contribute to elucidation of GLP-1-based therapeutic approach in AD/PD treatment. Expected publications will increase competitiveness of young researches in future grant applications.]]></summary_en></project><project>
<id>14709</id><title_hr><![CDATA[HRZZ projekt: Održiva plovidba smanjenom brzinom za nisko-ugljično brodarstvo (potpisivanje ugovora u tijeku)]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6793</user_id><user_firstLast_name>Nastia Degiuli</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-5494</code><acronim><![CDATA[]]></acronim><duration>01.12.2021 - 31.07.2026</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Brodogradnja, </scie_field_hr><scie_field_en>Naval architecture, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>865245</team_members_id><team_members_names><![CDATA[ Doktorand: Carlo Giorgio Grlj ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>14711</id><title_hr><![CDATA[Numerička rekonstrukcija u arheologiji pomorstva]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6254</user_id><user_firstLast_name>Smiljko Rudan</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-4139</code><acronim><![CDATA[NEREAS]]></acronim><duration>01.02.2022 - 01.08.2026</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Brodogradnja, </scie_field_hr><scie_field_en>Naval architecture, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>865260</team_members_id><team_members_names><![CDATA[ Doktorand: Šimun Sviličić ]]></team_members_names><keywords_hr><![CDATA[arheologija pomorstva, numeričko modeliranje, numerička rekonstrukcija, amfora, brod, brodska konstrukcija, brodolom]]></keywords_hr><keywords_en><![CDATA[archaeology of seafaring, numerical modelling, numerical reconstruction, amphora, ship, ship structure, shipwreck]]></keywords_en><summary_hr><![CDATA[Projekt NEREAS interdisciplinarni je istraživački projekt u kojem se primjenom suvremenih inženjerskih alata dolazi do novih znanstvenih spoznaja u arheologiji pomorstva. Brodovi su konstrukcije čije se ponašanje uslijed djelovanja različitih opterećenja može predvidjeti računalnim simulacijama, putem metode konačnih elemenata. No, primjena takvih alata u arheologiji pomorstva vrlo je ograničena. Projektom NEREAS nastoji se kapitalizirati iskustvo međunarodnog tima u nastojanju da se fokusirano odgovori na niz istraživačkih pitanja te jasno demonstrira znanstvena opravdanost i značenje primjene suvremenih inženjerskih metoda u analizi pomorskih konstrukcija i događaja iz prošlosti. Nastavljajući dosadašnja istraživanja na temu amfora, projekt NEREAS razmatrat će utjecaj promjene njihovoga oblika na njihovu čvrstoću. Sustavno istraživanje različitih oblika amfora pružit će znanstvene dokaze o razlozima njihove evolucije. Uz to, analizirat će se utjecaj interpretacije, odnosno varijacija prilikom rekonstrukcije forme broda, uzrokovanih ograničenošću arheoloških nalaza, na stabilitet i pomorstvenost broda. Znanstvena utemeljenost rekonstrukcije iznimno je važna prilikom izrade replika. Projekt NEREAS unaprijedit će dosadašnje simulacije potonuća broda fokusiranjem na konkretan brodolom. Primjenom tih simulacija bit će moguće znanstvenim metodama, na osnovi materijalnih dokaza, odrediti najvjerojatniji scenarij koji je doveo do tragičnog događaja. Projekt NEREAS učinit će pionirske korake i u komparativnoj analizi konstrukcijskih detalja broda, izrađenih od drva kao gradivnog materijala koji je nekada bio živo biće. Konačno, zahvaljujući opremanju bazena za modelska ispitivanja provest će se eksperimentalna istraživanja u hidromehanici za brodove Gagliana grossa i Condura Croatica, oba od iznimnog značenja za povijest hrvatskog pomorstva. Projektom će se obuhvatiti i eksperimentalno modeliranje starenja brodske konstrukcije. ]]></summary_hr><summary_en><![CDATA[The NEREAS project is an interdisciplinary research project in which the use of modern engineering tools brings new scientific insights into the archeology of seafaring. Ships are structures whose behavior due to the action of different loads can be predicted by computer simulations, using the finite element method. However, the application of such tools in maritime archeology is very limited. The NEREAS project seeks to capitalize on the experience of the international team in the effort to focus on a range of research questions, and clearly demonstrate the scientific justification and significance of the application of modern engineering methods in the analysis of marine structures and events of the past.Continuing ongoing research on amphorae, the NEREAS project will consider the impact of changing their shape on their strength. A systematic exploration of the various forms of amphorae will provide scientific evidence of the reasons for their evolution. In addition, the influence of interpretation, that is, variations of the reconstruction of the shape of the ship, caused by the limited archaeological resources, on the stability and seaworthiness of the ship will be analyzed. The scientific foundation of reconstruction is extremely important when making replicas.The NEREAS project will enhance the shipwreck simulations, focusing on a specific shipwreck. It will be possible to determine, on the basis of material evidence, the most plausible scenario that led to the tragic event. The NEREAS project will also take pioneering steps in comparative analysis of the structural details of ship made of wood, as a building material that was once a living being. Finally, thanks to the equipping of the model testing pool, experimental research will be conducted in hydro-mechanics for the ships Gagliana grossa and Condura Croatica, both of great importance for the Croatian maritime history. The project will also cover the experimental modeling of aging of ship structure.]]></summary_en></project><project>
<id>14713</id><title_hr><![CDATA[Prilagodba mjera kontrole populacije komaraca klimatskim promjenama u Hrvatskoj ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6027</user_id><user_firstLast_name>Branimir Hackenberger Kutuzović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-3492</code><acronim><![CDATA[]]></acronim><duration>15.11.2021 - 14.05.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Odjel za biologiju]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Department of Biology]]></institution_en><team_members_id>29216</team_members_id><team_members_names><![CDATA[ Doktorand: Tamara Đerđ ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>14714</id><title_hr><![CDATA[Koordinacijske reakcije makrocikličkih liganada u otopini]]></title_hr><title_en><![CDATA[]]></title_en><user_id>12384</user_id><user_firstLast_name>Gordan Horvat</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-7168</code><acronim><![CDATA[MacroSol]]></acronim><duration>18.10.2021 - 17.10.2025</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>865152</team_members_id><team_members_names><![CDATA[ Doktorand: Matija Modrušan ]]></team_members_names><keywords_hr><![CDATA[supramolekulska kemija, receptori, termodinamika, solvatacija, kaliksareni, ciklopeptidi, ciklodekstrini, kukurbiturili]]></keywords_hr><keywords_en><![CDATA[supramolecular chemistry, receptors, thermodynamics, solvation, calixarenes, cyclopeptides, cyclodextrins, cucurbiturils]]></keywords_en><summary_hr><![CDATA[Makrociklički spojevi zasigurno spadaju među najvažnije supramolekulske receptore aniona, kationa i neutralnih molekula. Ovaj će se projekt usmjeriti k dizajnu i sintezi brojnih takvih liganada, kao i detaljnoj fizikalno-kemijskoj karakterizaciji njihovih reakcija u otopini. Priredit će se niz derivata kaliksarena s različitim brojem supstituiranih fenolnih podjedinica. Ti će spojevi biti predvidivo vrlo efikasni i selektivni senzori za katione alkalijskih i zemnoalkalijskih metala te lantanoida, kao i raznih anionskih vrsta. Također će se istražiti reakcije receptora temeljenih na ciklodekstrinima i kukurbiturilima s različitim neutralnim supstratima. Predviđena istraživanja uključuju i veću skupinu ciklopeptida koji su prvenstveno zamišljeni kao receptori aniona. Neki od spomenutih liganada trebali bi biti iznimno osjetljivi fluorescentni senzori, a posebna pažnja bit će posvećena dizajnu receptora sa zadovoljavajućom topljivošću u vodi. Koordinacijske reakcije navedenih spojeva s raznim supstratima u nizu otapala detaljno će se proučiti sveobuhvatnim pristupom koji uključuje termodinamička, komputacijska i strukturna istraživanja. Koristit će se razne eksperimentalne metode, poput mikrokalorimetrije, UV-Vis spektrofotometrije, fluorimetrije, spektroskopije NMR, konduktometrije, potenciometrije i rentgenske strukturne analize. Receptori i njihovi kompleksi bit će također istraženi primjenom molekulske dinamike i drugih računalnih metoda. Takav pristup omogućit će pouzdano određivanje termodinamičkih veličina (konstante stabilnosti, standardne Gibbsove energije, entalpije i entropije reakcija kompleksiranja i otapanja) te dobivanje niza strukturnih informacija. Posebna će pažnja biti posvećena utvrđivanju utjecaja stvaranja vodikovih veza i solvatacije reaktanata i produkata na ravnoteže reakcija kompleksiranja. Prikupljeni termodinamički podatci trebali bi omogućiti vrlo detaljan uvid u ključne čimbenike koji određuju ravnotežni doseg istraživanih reakcija. ]]></summary_hr><summary_en><![CDATA[The efficient and selective macrocyclic receptors for charged and neutral species have played a key role in the development of supramolecular chemistry over the last few decades. This project will focus on the design and synthesis of a variety of such compounds as well as detailed physicochemical characterization of their reactions in solution. A series of calixarene derivatives with diverse number of substituted phenolic subunits will be prepared with the aim of obtaining the ligands which are capable of strongly and selectively binding alkaline, alkaline earth and lanthanide metal cations, and different kinds of anions. The receptors based on cyclodextrins and cucurbiturils and their reactions with several neutral guests will be explored as well. The investigation will also include a number of cyclopeptide derivatives primarily being designed as anion receptors. Some of the above mentioned compounds are envisaged to be highly efficient fluorescent receptors and/or to be water-soluble. The complexation abilities of all mentioned ligands towards various substrates in many solvents will be explored by using an integrated approach which includes thermodynamic, computational, and structural studies. A number of experimental methods (microcalorimetry, UV-Vis spectrophotometry, fluorimetry, NMR spectroscopy, conductometry, potentiometry, X-ray diffraction) as well as molecular dynamics and other computational techniques will be employed. Such an approach will yield detailed and reliable thermodynamic quantities (stability constants, reaction and solution Gibbs energies, enthalpies, and entropies) and the structural information regarding the receptors and their complexes. Particular attention will be paid to the hydrogen-bonding and solvent effects on the equilibria of binding reactions. The obtained thermodynamic and structural information will provide a detailed insight into the main factors governing the studied complexation processes.]]></summary_en></project><project>
<id>14716</id><title_hr><![CDATA[Sinteza supramolekulskih samo-udruženih nanostruktura za izgradnju naprednih funkcionalnih materijala]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1104</user_id><user_firstLast_name>Ruža Frkanec</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-6796</code><acronim><![CDATA[SUPeRNANO]]></acronim><duration>03.01.2022 - 03.01.2026</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Interdisciplinarne prirodne znanosti, </scie_field_hr><scie_field_en>Interdisciplinary natural sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu]]></institution_hr><institution_en><![CDATA[University of Zagreb]]></institution_en><team_members_id>865253</team_members_id><team_members_names><![CDATA[ Doktorand: Marcela Šišić ]]></team_members_names><keywords_hr><![CDATA[supramolekulska kemija,  sinteza, samo-udruge, nanostrukture, napredni funkcionalni materijala]]></keywords_hr><keywords_en><![CDATA[Supramolecular Chemistry, Synthesis, Self-assembles, Nanostructures, Advanced Functional Materials]]></keywords_en><summary_hr><![CDATA[Istraživanja u okviru predloženog projekta su interdisciplinarna s ciljem dizajna, supramolekulske  sinteze i karakterizacije novih samoorganizirajućih nano-struktura za izgradnju naprednih funkcionalnih materijala. Molekularno samoudruživanje koristi prednosti supramolekulskih interakcija (ionske, hidrofobne, van der Waals-ove, vodikove i koordinacijske veze)  koje omogućavaju konstruiranje novih nanostruktura  atraktivnih svojstava. Temeljeno na zakonitostima supramolekulske kemije, „bottom-up“ pristup za projektiranje funkcionalnih struktura u nano dimenzijama omogućuje nastajanje vrlo sofisticiranih materijala za široku primjenu. Takve strukturne karakteristike danas su dobro poznate i mogu se precizno kontrolirati kako bi se uvela i prilagodila specifična funkcionalna svojstva samoorganiziranih nanomaterijala. Nadalje, ovi sustavi pokazuju složenu morfologiju i dinamiku te imaju veliki potencijal za primjenu u biomedicinskim znanostima, informacijskim tehnologijama i znanostima o okolišu. U nastavku naših istraživanja supramolekulskih sustava pažnja u ovom projektu bit će usmjerena na dva glavna područja: 1) nanoproizvode, sintezu i karakterizacija novih mekih nanomaterijala temeljenih na organo- i hidro-gelovima s inkorporiranim oksalilamidnim ili fumaramidnim centralnim jedinicama i sinteze bioinspiriranih supramolekulskih sustava baziranih na samoorganizacijama  prirodnih peptida, priprava novih materijala polimerizacijom gelske mreže i razvoj novih supramolekulskih materijala koje uključuju fotoaktivne funkcionalne skupine 2) dizajn, priprema i karakterizacija novih funkcionalnih supramolekulskih sustava baziranih na liposomima i ß-ciklodekstrinama za ciljanu dostavu lijekova i istraživanje staničnog prepoznavanja. Nadalje, testirat će se biološki potencijal sintetiziranih funkcionalnih supramolekulskih sustava u dostavi lijekova i genskoj dostavi.]]></summary_hr><summary_en><![CDATA[Research in the framework of the proposed project is interdisciplinary with the aim of design, supramolecular synthesis and characterization of new functional supramolecular self-assembled nanostructures for construction of advanced functional materials. Molecular self-assembly usually takes advantage of supramolecular interactions (ionic, hydrophobic, van der Waals, hydrogen and coordination bonds) which allow construction of new nanostructures with attractive properties. Based on the rules of supramolecular chemistry, the bottom-up approach to design functional structures at the nanoscale is currently producing highly sophisticated materials for wide application. These structural features are nowadays well understood and can be finely controlled in order to introduce and tune specific functional properties of self-assembled nanomaterials. Further, such systems exhibit a complex array of morphologies and dynamics and have a huge potential for new applications in biomedical sciences, information technologies and environmental sciences. In continuation of our previous research of self-assembly systems the attention in this project will be focused on two main areas of research: 1) nanofabrication, preparation and characterization of new soft nanomaterials based on organo- and hydro-gels with incorporated oxalylamide or fumaramide central units and synthesis of bioinspirated supramolecular systems based on self-assembled natural peptides, the preparation of new materials by gel polymerization and the development of new supramolecular materials that incorporate photoactive functional groups 2) design, preparation and characterization of new functional supramolecular systems based on liposomes and ß-cyclodextrines for targeted drug delivery and surface recognition studies. Further, biological potential of synthesized functional supramolecular systems in drug and gene delivery will be tested. ]]></summary_en></project><project>
<id>14717</id><title_hr><![CDATA[Otkriće i razvoj novih biološki aktivnih kvaternih amonijevih spojeva derivata kinuklidina]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6130</user_id><user_firstLast_name>Matilda Šprung</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-9985</code><acronim><![CDATA[QACBioAct]]></acronim><duration>01.12.2021 - 30.11.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Science]]></institution_en><team_members_id>865120</team_members_id><team_members_names><![CDATA[ Doktorand: Antonio Sabljić ]]></team_members_names><keywords_hr><![CDATA[kvaterni amonijevi spojevi, kinuklidin, derivati kinuklidina, biološka aktivnost, mehanizam rezistencije]]></keywords_hr><keywords_en><![CDATA[quaternary ammonium compounds, quinuclidine, quinuclidine derivatives, biological activity, resistance mechanism]]></keywords_en><summary_hr><![CDATA[Kvaterni amonijevi spojevi (QACs) su amfipatske molekule antimikrobnih svojstava s primjenom u brojnim industrijama. Spojevi benzalkonijev klorid, cetilpiridinijev klorid i didecildimetilamonijev klorid česte su komponente mnogih antiseptika. S obzirom da su QACs amfipatski spojevi s djelovanjem na bakterijsku membranu, dugo se smatralo da je rezistencija na ove spojeve gotovo nemoguća. Međutim, novija istraživanja ukazuju da je rezistencija na QACs široko rasprostranjena zbog Qac efluks pumpi, ali i drugih, još nerazjašnjenih mehanizama otpornosti. Naša dosadašnja istraživanja pokazala su kako derivati kinuklidina mogu poslužiti kao molekulska okosnica za razvoj novih biološki aktivnih QACs. Cilj je ovog istraživanja sintetizirati nove derivate kinuklidin-3-amida i njihove QACs te im ispitati biološku aktivnost (MIC i MBC prema izabranom panelu bakterija, inhibitorno djelovanje na bakterijske biofilmove, antioksidacijsku aktivnost te citotoksičnost). Djelovanje biološki aktivnih spojeva na staničnu membranu, ispitat će se mjerenjem propusnosti membrane za propidijev jodid i analizom uzorka bakterijskih stanica mikroskopijom atomskih sila. Kako bi se utvrdio mogući utjecaj spojeva na ekspresiju Qac efluks pumpi, ispitat će se njihova interakcija s ciljnim makromolekulama metodom termoforeze. Razvoj rezistencije i ekspresija faktora virulencije u uzorcima bakterijskih kultura izloženih antimikrobnim spojevima, analizirat će se masenom spektrometrijom. Očekivani rezultat predloženog projekta su novi QACs, derivati kinuklidina, značajnih bioloških svojstava, koji bi mogli imati primjenu u farmaceutskoj, prehrambenoj i poljoprivrednoj industriji.]]></summary_hr><summary_en><![CDATA[Quaternary Ammonium Compounds (QACs) are amphiphilic molecules of antimicrobial properties with application in numerous industries. Compounds such as benzalkonium chloride, cetylpyridinium chloride and didecildimethylammonium chloride are common components of many antiseptics. Since QACs are amphiphilic molecules that act on the bacterial membrane, it was long believed that resistance toward these compounds is virtually impossible. However, recent studies suggested that resistance to QACs is widespread not only due to Qac efflux pumps, but also due to another, yet unknown mechanism of resistance. Our previous studies have shown that quinuclidinium containing derivatives can serve as a molecular scaffold for development of new QACs. The aim of this study is to develop new derivatives of quinuclidin-3-amide and their QACs, and to investigate their biological activity (MIC and MBC against the selected panel of bacteria, antibiofilm, antioxidative activity and cytotoxicity). The mode of action for selected bioactive molecules will be investigated by measuring membrane permeability for propidium iodide and by analysing a bacterial sample with atomic force microscope. To determine the possible influence of compounds on expression of Qac efflux pumps, their interaction with targeted macromolecules will be investigated by thermophoresis. The development of resistance and expression of virulence factors in samples of bacterial cultures exposed to antimicrobial compounds will be analysed by mass spectrometry. The expected outcome of the proposed project is discovery of new quinuclidinium derived bioactive QACs, with potential application in pharmaceutical, food and agricultural industries.]]></summary_en></project><project>
<id>14718</id><title_hr><![CDATA[Time to Become Digital in Law (DIGinLaw)]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5986</user_id><user_firstLast_name>Mirela Župan</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-6700</code><acronim><![CDATA[]]></acronim><duration>18.10.2021 - 17.10.2025</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Pravo, </scie_field_hr><scie_field_en>Law, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Pravni fakultet u Osijeku]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Law]]></institution_en><team_members_id>865156</team_members_id><team_members_names><![CDATA[ Doktorand: Jura Golub ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>14719</id><title_hr><![CDATA[Od aromatskih spojeva s dušikom do novih funkcionalnih organskih materijala]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4656</user_id><user_firstLast_name>Ivana Biljan</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-5475</code><acronim><![CDATA[FunMaterials]]></acronim><duration>27.10.2021 - 26.10.2025</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>865148</team_members_id><team_members_names><![CDATA[ Doktorand: Laura Nuić ]]></team_members_names><keywords_hr><![CDATA[aromatske građevne jedinke s dušikom, funkcionalni materijali, modularni dizajn, porozni organski materijali, slojevi na površinama]]></keywords_hr><keywords_en><![CDATA[aromatic building blocks with nitrogen, functional materials, modular design, porous organic materials, surface adlayers]]></keywords_en><summary_hr><![CDATA[Modularni dizajn odozdo prema gore, odnosno pristup povezivanja molekularnih građevnih jedinki unaprijed određene geometrije i funkcionalnosti na predvidljiv način, važan je put prema funkcionalnim organskim arhitekturama. U ovom projektu, osnovna ideja je upotrijebiti strukturno slične molekularne građevne jedinke, aromatske spojeve s dušikom, za dizajn samoudruženih višeslojeva i 2D polimera na čvrstim površinama s mogućom primjenom u molekularnoj elektronici, te za sintezu poroznih organskih materijala koji bi se mogli koristiti za adsorpciju i pohranjivanje plinova.Aromatski C-nitrozo spojevi izloženi na međupovršini metal-otopina koristit će se kao predlošci za hijerarhijsku izgradnju azodioksidnih višeslojeva interakcijama s aromatskim dinitrozo derivatima. Mehanizam nastajanja i kinetika rasta nitrozo/azodioksidnih slojeva na površinama istražit će se elipsometrijom, AFM i STM mikroskopijom te računalnim metodama. Nadalje, provest će se in situ EC-STM istraživanja od kojih se očekuje pružanje informacija o strukturi i dinamici na razini pojedinačnih molekula. Također će se istražiti polimerizacija aromatskih polinitrozo derivata na površinama i moguće nastajanje površinom ograničenih 2D azodioksidnih polimera. Kristalni (COF-ovi) ili amorfni (COP-ovi) porozni organski materijali mogu nastati povezivanjem organskih građevnih jedinki preko kovalentnih veza. Aromatske građevne jedinke s nitrozo, nitro i/ili amino skupinama bit će korištene za modularni dizajn azo, azoksi i azodioksidnih COF-ova i/ili COP-ova. Strukturna i funkcionalna svojstva poroznih materijala bit će karakterizirana spektroskopijom, termičkom analizom, rentgenskom difrakcijom, mjerenjima specifične površine i molekularnim modeliranjem. Cilj je ispitati utjecaj različitih dušik-dušik veza na strukturna (kristalne naspram amorfnih krutina) i funkcionalna svojstva konačnih materijala te identificirati obećavajuće nove porozne sustave za učinkovito hvatanje CO2, glavnog stakleničkog plina.]]></summary_hr><summary_en><![CDATA[A bottom-up modular design, an approach of piecing together molecular building blocks of predetermined geometry and functionality in a predictable manner, is an important route toward the functional organic architectures. Within this project, the basic idea is to employ structurally similar molecular building blocks, nitrogen-containing aromatic compounds, for a design of self-assembled multilayers and 2D polymers on solid surfaces with possible applications in molecular electronics, and for the synthesis of porous organic materials which could be used in gas adsorption and storage. Aromatic C-nitroso groups exposed at the metal-solution interface will be used as templates for hierarchical construction of azodioxy multilayers by interactions with aromatic dinitroso derivatives. Formation mechanism and growth kinetics of nitroso/azodioxy adlayers on surfaces will be explored by ellipsometry, AFM and STM microscopy, and computational methods. In addition, in situ EC-STM studies expected to provide structure and dynamics information at single-molecule level will be performed. Polymerization of aromatic polynitroso compounds on surfaces and possible formation of surface-confined 2D azodioxy polymers will be also investigated. Crystalline (COFs) or amorphous (COPs) porous organic materials can be formed by linking organic building units through covalent bonds. Aromatic building blocks with nitroso, nitro and/or amino groups will be utilized for modular design of azo, azoxy and azodioxy COFs and/or COPs. Structural and functional features of porous materials will be characterized by spectroscopy, thermal analysis, X-ray diffraction, surface area measurements and molecular modelling. The aim is to examine the effect of different nitrogen-nitrogen linkages on structural (crystalline vs. amorphous solids) and functional properties of final materials and to identify the promising new porous organic systems for the effective capture of CO2, the main greenhouse gas.]]></summary_en></project><project>
<id>14721</id><title_hr><![CDATA[Dinaridski predgorski bazen između dva eocenska terminalna optimuma: mogući scenarij za sjevernojadranski bazen]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5918</user_id><user_firstLast_name>Vlasta Ćosović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-9533</code><acronim><![CDATA[BREEMECO]]></acronim><duration>01.12.2021 - 30.11.2025</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Geologija, </scie_field_hr><scie_field_en>Geology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>865213</team_members_id><team_members_names><![CDATA[ Doktorand: Igor Pejnović ]]></team_members_names><keywords_hr><![CDATA[Eocen, predgorski bazen, Dinaridi, karbonatne stijene, klastiti, termalni optimumi]]></keywords_hr><keywords_en><![CDATA[Eocene, Foreland basin, Dinarides, Carbonates, Clastics, Thermal optima]]></keywords_en><summary_hr><![CDATA[Glavni cilj projekta BREEMECO je istražiti i kvantificirati promjene u zajednicama organizama u plitkomorskim i pelagičkim okolišima izazvane eocenskim termalnim odstupanjima (ranim - i srednje-eocenskim klimatskim optimumima) u području Vanjskih Dinarida. Cilj će se postići: i) istraživanjem promjena sastava zajednice bentosa ciljanih uzoraka Foraminiferskih vapnenanaca (teksturne i strukturne osobine čega su ključne za eliminaciju lokalnih taložnih utjecaja), ii) istraživanjem mineraloških, geokemijskih, sedimentoloških te mikro- i nano-paleonotoloških osobina pelagičkih sedimenta nastalih tijekom navedenih razdoblja, te iii) procjenom (kvantitativnom i kvalitativnom) veličine i karaktera promjena na pojedinim skupinama organizama. Unazad 20-tak godina iz svjetskih su primjera poznate posljedice izazvane jednom odnosno drugom termalnom promjenom na morske strujne režime i na sastav zajednica bentosa u dubokomorskim okolišima, ali do sada nisu opisane promjene koje su se dogodile u transektu plitkomorski – pelagički okoliš. Prostor Dinaridskog predgorskog bazena je jedinstven jer nalazimo plitkomorske i dubokomorske naslage istaložene u rasponu od 50 do 40 milijuna godina i u okviru ovoga projekta utvrditi će se i korelirati promjene izazvane termalnim događanja u naslagama. Dobiveni trendovi promjena mogu se koristiti pri procjeni rizika mogućih recentnih promjena koje se već događaju u sjevernom dijelu Jadranskog mora (promjene uočene na zajednicama dna povezane s hipoksijom u posljednjih 500 godina). Značajni napor će se posvetiti preciznom biostratigrafskom zoniranju eocenskih naslaga (dileme o starosti fliških naslaga), intenzitetu trošenja tek formiranih Dinarida ali i drugih mladih struktura u okruženju, čijim se materijalom punio predgorski bazen. BREEMECO projekt će imati i snažnu međunarodnu komponentu koja uključuje istraživače i odgovarajuće institucije, što će rezultirati povećanjem učinkovitosti i umreženosti hrvatske geološke zajednice.]]></summary_hr><summary_en><![CDATA[The main objective of the BREEMECO project is to investigate and quantify changes in benthic communities from the shallow-water and pelagic environments during the Eocene climatic episodes (Early and Middle Eocene Optima) in the External Dinarides. The aims are the following: i) to detect and interpret the changes in composition of bethos in the Foraminiferal limestones from selected localities, their textural and structural characteristics in particular; ii) to study mineralogical, geochemical, sedimentological, micro- and nano-paleonotological properties of pelagic sediments deposited during these thermal episodes, and iii) to evaluate (quantitatively and qualitatively) magnitude and character of changes in both benthic communities. Since the 2000s, the consequences of one or the other thermal changes have been studied only in deepwater sediments, or only from one or another episode, but so far no studies have been made in the transect shelf-basin. The Dinaridic Foreland basin is one of a few locations in the world where these transition and changes can be studied because deposits covering 50 to 40 Ma occur. This project will correlate the changes from both episodes and from the shallow to pelagic part of the basin. The obtained trends can be used to estimate the risk of changes occurring in the Northern Adriatic (changes observed in benthos in the last 500 ys due to hypoxia). The project will make a significant effort to devise a precise biostratigraphic zonation (related to the controversies about the age of flysch), the intensity of weathering of &#39;&#39;just up-lifted&#39;&#39; Dinarides and other young structures in the vicinity. The BREEMECO project will also have a strong international component involving researchers and relevant institutions, thus will result in increased efficiency and networking of the Croatian geological community.]]></summary_en></project><project>
<id>14722</id><title_hr><![CDATA[Otpad i Sunce u službi fotokatalitičke razgradnje Mikroonečišćivala u vodama (OS-Mi)]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5338</user_id><user_firstLast_name>Domagoj Vrsaljko</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-5999</code><acronim><![CDATA[]]></acronim><duration>01.08.2021 - 31.01.2026</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Kemijsko inženjerstvo, </scie_field_hr><scie_field_en>Chemical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet kemijskog inženjerstva i tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Chemical Engineering and Technology]]></institution_en><team_members_id>865027</team_members_id><team_members_names><![CDATA[ Doktorand: Marijan-Pere Marković ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>14723</id><title_hr><![CDATA[De novo sastavljanje genoma i metagenoma]]></title_hr><title_en><![CDATA[]]></title_en><user_id>18951</user_id><user_firstLast_name>Krešimir Križanović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-3717</code><acronim><![CDATA[SIGMA]]></acronim><duration>06.12.2021 - 05.12.2025</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>865247</team_members_id><team_members_names><![CDATA[ Doktorand: Josipa Lipovac ]]></team_members_names><keywords_hr><![CDATA[de novo, assembly, genome, metagenome, seqeuncing]]></keywords_hr><keywords_en><![CDATA[de novo, sastavljanje, genom, metagenom, sekvenciranje]]></keywords_en><summary_hr><![CDATA[Prvi moderni alat za sastavljanje genoma proizvela je Celera 2001. godine za sastavljanje prve verzije ljudskog genoma. Od tada su mnoge metode za sastavljanje genoma razvijene i korištene, ali konačni genomi visoke preciznosti još uvijek zahtijevaju dugotrajan angažman istraživačkih skupina i dugotrajno ručno provjeravanje i prepravljanje. Najveći izazov u proizvodnji visoko preciznih i neprekinutih sastavljenih genoma su dugi nizovi ponavljajući regija. Nove i nadolazeće tehnologije za sekvenciranje tvrtki Pacific Biosciences i Oxford Nanopore Technologies daju nam nadu da je automatizacija postupka sastavljaja genoma moguća. Nove tehnologije proizvode očitanja velike duljine, ali i velikog postotka pogreške. Duljina proizvedenih očitanja može premašiti i nekoliko stotina tisuća nukleotida, što bi trebalo biti dovoljno za ispravnu rekonstrukciju većine ponavljajućih dijelova genoma. Međutim, znanstvena zajednica još uvijek ima značajne poteškoće prilikom sastavljanja većih genoma (genoma životinja i biljaka) te prilikom sastavljanja genoma mikrobnih zajednica. Metode za sastavljanje obično koriste pristup utemeljen na grafovima. Grafovi se grade spajajući očitanja koja se preklapaju, a zatim se heurističkim metodama traži put kroz graf koji će svako očitanje obići samo jednom. To je često nemoguće zbog petlji u grafu, uzrokovanih neispravnim preklapanjima i ponavljajućim djelovima genoma. To je posebno izraženo kod dugih genoma koji se sastoje od većeg broja kromosoma te kod metagenomeskih uzoraka koji sadrže od desetak pa do nekoliko stotina organizama. Glavni cilj ovog projekta jest razviti metode pomoću kojih koje će se proizvesti (i) potpuni i precizni dugi genomi te (ii) genomi organizama iz metagenomskog uzorka. Da bi to postigli planiramo razviti nekoliko metoda utemeljenih na grafovima i strojnom učenju pomoću kojih ćemo detektirati neispravna preklapanja.]]></summary_hr><summary_en><![CDATA[The first modern software for DNA assembly was developed by Celera for generating the draft of human genome in 2001. Since then ample of methods have tried to correctly assemble genomes, but a high-quality assembly still requires laborious work of large groups of scientists and many years of data curation. The biggest challenges for achieving high accuracy and contiguity of genome assemblies have been long stretches of highly repetitive regions. The recent advent of new generation of sequencing technologies such as those of companies Pacific Biosciences and Oxford Nanopore Technologies gives us hope that automated complete genome reconstruction is feasible. They produce long, but error-prone reads whose size exceeds hundreds of thousand nucleotides which should be long enough for spanning most repetitive parts. Nevertheless, researchers still struggle to completely assemble long genomes (ie. animal and plant genomes) and genomes of microbial communities. Assembly methods usually use a graph-based approach which starts with building a graph by joining overlapping reads, followed by using heuristics to find a path which visits each read once. However, this is often unfeasible because of tangles in the graph which occur due to incorrect read overlaps and repetitive regions. This is particularly critical for both long genomes with many chromosomes and for metagenomic samples with anything from ten to several hundred present genomes. The primary aim of this project is the development of methods which will result in (i) complete large genomes and (ii) accurate metagenomic assemblies. To achieve this aim we will develop several graph-based and machine learning methods for detection of incorrect overlaps.]]></summary_en></project><project>
<id>14724</id><title_hr><![CDATA[Interkalirani Dihalkogenidi Prijelaznih Metala]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3247</user_id><user_firstLast_name>Petar Popčević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-9168</code><acronim><![CDATA[iTMD]]></acronim><duration>15.08.2022 - 14.08.2026</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut za fiziku]]></institution_hr><institution_en><![CDATA[Institute of Physics in Zagreb]]></institution_en><team_members_id>865337</team_members_id><team_members_names><![CDATA[ Doktorand: Gaurav Pransu ]]></team_members_names><keywords_hr><![CDATA[dihalkogenidi prijelaznih metala, interkalacija, magnetska uređenja, frustracija, nered, topološka stanja, uniaksijalni tlak]]></keywords_hr><keywords_en><![CDATA[transition metal dichalcogenides, intercalation, magnetic orderings, frustration, disorder, topological states, uniaxial pressure]]></keywords_en><summary_hr><![CDATA[Ovaj projektni prijedlog baziran je na dihalkogenidima prijelaznih metala (TMD). Oni su porodica slojevitih (kvazi dvodimenzionalnih) materijala koji uslijed reducirane dimenzionalnosti pokazuju zanimljiva osnovna stanja kao što su supravodljivost i različiti valovi gustoće naboja (CDW). Slojevi su vezani Van der Waals-ovim silama te je između tih slojeva moguće interkalirati razne atome i molekule. Istraživanja na ovom projektu tiču se različitih interkalacija prijelaznih metala u TMD-e. Uslijed prijenosa dijela naboja sa interkalanata na slojeve domaćina interkalirani ioni nose magnetski moment te se sustav može magnetski urediti. Različiti prijelazni metali pokazuju različita feromagnetska i antiferomagnetska uređenja za različite stupnjeve interkalacije. Zanimljiv je slučaj interkalacije 1/3 magnetskih iona po jediničnoj ćeliji roditeljskog spoja, pošto se tada magnetski ioni urede na trokutastoj rešetci te se u slučaju anitferomagnetskih međudjelovanja među njima javlja frustracija u sustavu. U okviru ovoga projekta planiramo proučavati utjecaj hidrostatskog i uniaksijalnog tlaka na magnetski uređene faze osobito na efekte frustracije te odrediti relativne važnosti različitih međudjelovanja kao što su RKKY, superizmjena i Kondo zasjenjenje te njihovu međuigru. Isto tako planiramo promatrati kako se osnovna stanja roditeljskih spojeva (CDW, supravodljivost) potiskuju interkalacijom/tlakom te kakav je njihov utjecaj na novonastale magnetske faze. Također nas zanima kakav je utjecaj nereda na osnovna stanja kao i mogućnost postojanja topoloških efekata u TMDima. ]]></summary_hr><summary_en><![CDATA[This project proposal is based on transition metal dichalogenides (TMDs). They are a family of layered (quasi two-dimensional) materials which, due to reduced dimensionality, exhibit interesting ground states such as superconductivity and different charge density waves (CDWs). The layers are connected with Van der Waals forces and it is possible to intercalate various atoms and molecules in-between those layers. The research on this project concerns different intercalations of transition metals in TMDs. Due to the transfer of part of the electronic charge from the intercalant to the host layers, intercalated ions carry the magnetic moment and the system can be magnetically ordered. Different transition metals show different ferromagnetic and antiferromagnetic orderings for different intercalation rates. Interesting case is intercalation with 1/3 of magnetic ions per one unit cell of parent compound, since the magnetic ions are then ordered on the hexagonal lattice, and in the case of anitferromagnetic interactions frustration occurs in the system. Within this project, we plan to study the influence of hydrostatic and uniaxial pressure on the magnetically ordered phases, in particular on the effects of frustration and to determine the relative importance of different interactions such as RKKY, superexchange and Kondo screening and their interplay. We also plan to observe how the ground states of parent compounds (CDW, superconductivity) are suppressed by intercalation/pressure, and how they influence newly established magnetic phases. We are also interested in the effect of disorder on the ground state and possibility of topological effects in TMDs.]]></summary_en></project><project>
<id>14725</id><title_hr><![CDATA[Meteorological uncertainty management for Flow Management Positions - FMPMet]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1234</user_id><user_firstLast_name>Doris Novak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-6407</code><acronim><![CDATA[]]></acronim><duration>01.11.2021 - 31.10.2025</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Tehnologija prometa i transport, </scie_field_hr><scie_field_en>Transport technology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet prometnih znanosti]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Transport and Traffic Sciences]]></institution_en><team_members_id>865144</team_members_id><team_members_names><![CDATA[ Doktorand: Kristina Samardžić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>14727</id><title_hr><![CDATA[Razvoj potopljenog agregata za male hidroelektrane s niskim padom vode, ESIF, KK.01.2.1.02.0017]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4134</user_id><user_firstLast_name>Elvira Vidović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-4120</code><acronim><![CDATA[]]></acronim><duration>20.10.2021 - 22.04.2026</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Kemijsko inženjerstvo, </scie_field_hr><scie_field_en>Chemical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet kemijskog inženjerstva i tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Chemical Engineering and Technology]]></institution_en><team_members_id>865185</team_members_id><team_members_names><![CDATA[ Doktorand: Andrea Špoljarić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>14729</id><title_hr><![CDATA[Algoritmi dubokog podržanog učenja za upravljanje rizicima]]></title_hr><title_en><![CDATA[]]></title_en><user_id>13406</user_id><user_firstLast_name>Zvonko Kostanjčar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-6312</code><acronim><![CDATA[DREAM]]></acronim><duration>18.10.2021 - 17.10.2025</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>865163</team_members_id><team_members_names><![CDATA[ Doktorand: Sven Goluža ]]></team_members_names><keywords_hr><![CDATA[duboko podržano učenje, kvantitativno upravljanje rizicima, duboko učenje reprezentacija, računalne financije, optimizacija portfelja]]></keywords_hr><keywords_en><![CDATA[deep reinforcement learning, quantitative risk management, deep representation learning, computational finance, portfolio optimization]]></keywords_en><summary_hr><![CDATA[Potreba za upravljanjem neizvjesnošću ishoda u procesima donošenja odluka dovela je do razvoja područja upravljanja rizicima. Tehnološki napreci i rastuća dostupnost podataka potaknuli su korištenje statističkih pristupa i kvantitativnog upravljanja rizicima u mnogim područjima, poput aktuarskih procjena, kreditnog rizika i optimizacije portfelja. Međutim, važan aspekt upravljanja rizicima – intrinzično sekvencijalna priroda problema – je zanemaren jer tradicionalne statističke metode razmatraju samo rizik jedne izolirane akcije bez uzimanja u obzir utjecaja nizova akcija na dugoročne rizike. U međuvremenu, evolucija računalne snage omogućila je uspješno korištenje složenih pristupa strojnog učenja, uključujući duboke arhitekture, u stvarnim problemima. U ovom projektnom prijedlogu, motivirani zahtjevima suvremenih scenarija upravljanja rizicima, fokusiramo se na pristup zasnovan na podržanom učenju, uzimajući u obzir neizvjesnosti budućih ishoda kao izvor rizika u problemu izravnog adaptivnog upravljanja gdje model razmatranog sustava nije potpuno poznat. Opći cilj ovog projekta je razviti novu klasu algoritama podržanog učenja osjetljivih na rizik za dinamičke okoline s primjenama u upravljanju financijskim rizicima. Konkretno, unutar predloženog projekta planiramo: (i) uključiti cilj osjetljiv na rizik u algoritme podržanog učenja temeljene na politici (ii) razviti novu klasu algoritama podržanog učenja temeljenu na aproksimaciji funkcija vrijednosti s eksplicitnim modeliranjem rizika uključenog u donošenje odluka agenta; (iii) implementirati modele reprezentacije prostora stanja koji izvlače korisne informacije iz podataka vremenskih nizova korištenjem latentnih modela; i (iv) oblikovati i implementirati metode optimizacije portfelja na temelju predloženih algoritama. Novo razvijeni algoritmi podržanog učenja poboljšat će postojeće metode i omogućiti principijelniji pristup u procesima donošenja odluka u neizvjesnim okolnostima.]]></summary_hr><summary_en><![CDATA[The need to manage uncertainty of outcomes in decision-making has given rise to the field of risk management. Advances in technology and rising availability of data have motivated the use of statistical approaches and quantitative risk management in many areas, such as actuarial assessments, credit risk, or portfolio optimization. However, an important aspect of risk management – its intrinsically sequential nature – is neglected by traditional statistical methods which only consider the risk of a single isolated action without taking into consideration the effect of sequences of actions on long-term risks. Meanwhile, the evolution of computational power has enabled the successful employment of complex machine learning approaches, including deep architectures, to real-world problems. In this project proposal, motivated by the requirements of modern risk management scenarios, we focus on a reinforcement learning based approach, by regarding the uncertainties of future outcomes as sources of risk in a direct adaptive control problem where the model of the considered system is not completely known. The overall goal of this project is to develop a novel class of risk-sensitive reinforcement learning algorithms in dynamic environments with applications in financial risk management. Specifically, within the proposed project we plan to: (1) incorporate a risk-sensitive objective in policy based reinforcement learning algorithms; (2) develop a new class of reinforcement learning algorithms based on value function approximation with explicit modeling of risk involved in agent decision making; (3) implement state space representation models that extract useful information from time series data by exploiting latent models; and (4) design and implement portfolio optimization methods based on proposed algorithms. The newly developed algorithms will ameliorate the typical flaws of the existing methods and enable decision makers to pursue a more principled approach to uncertainty.]]></summary_en></project><project>
<id>14731</id><title_hr><![CDATA[Blue technology - Developing innovative technologies for sustainability of Adriatic Sea (InnovaMare)]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5962</user_id><user_firstLast_name>Nikola Mišković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-9415</code><acronim><![CDATA[]]></acronim><duration>01.09.2021 - 31.08.2025</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Temeljne tehničke znanosti, </scie_field_hr><scie_field_en>Basic engineering sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>865035</team_members_id><team_members_names><![CDATA[ Doktorand: Luka Mandić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>14733</id><title_hr><![CDATA[Javno opravdanje i pluralizam sposobnosti]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1453</user_id><user_firstLast_name>Elvio Baccarini</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-2742</code><acronim><![CDATA[JOPS]]></acronim><duration>24.09.2021 - 23.07.2026</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filozofija, </scie_field_hr><scie_field_en>Philosophy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Filozofski fakultet u Rijeci]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>865088</team_members_id><team_members_names><![CDATA[ Doktorand: Iva Martinić ]]></team_members_names><keywords_hr><![CDATA[evaulativni standardi, javno opravdanje, John Rawls, pluralizam, pristup temeljen na sposobnostima]]></keywords_hr><keywords_en><![CDATA[capability approach, evaluative standards, John Rawls, pluralism, public justification]]></keywords_en><summary_hr><![CDATA[Intencija je projekta, iz područja filozofije politike, razraditi teoriju opravdanja javnih evaluativnih standarda koja uvažava perspektive djelatnika u okolnostima pluralizma, uskladiti je s pristupom utemeljenim na sposobnostima, te primijeniti je na nekim relevantnim slučajevima. Evaluativni standardi su kriteriji kojima prosuđujemo moralna pravila, načela pravednosti, karakterne osobine te osobna i društvena stanja. 	Cilj projekta postižemo time što zadržavamo inspiraciju Johna Rawlsa i smatramo da javni evaluativni standardi nisu legitimni onda kada su opravdani razlozima koji vrijede za samo neke osobe. Ipak, za razliku od Rawlsa, rješenje ne vidimo u opravdanju koje referira isključivo na zajedničke razloge pojedinaca i na njihove moći racionalnosti i razložnosti. U fokus moralne pažnje dovodimo sve osobe i njihove perspektive, bez obzira na emocionalne i kognitivne raznolikosti. Navedeno postižemo zadržavanjem inspiracije Marthe Nussbaum, prema kojoj moralni status i pažnju treba usmjeriti i djelatnicima koji nisu racionalni i razložni, te im treba jamčiti ili podupirati za njih relevantne sposobnosti. Postižemo sponu između ovih dviju inspiracija tako što zadržavamo inspiraciju u Gausovoj teoriji javnog uma. Prema njemu javne evaluativne standarde trebamo opravdati snažnim poštivanjem pluralizma, uzimajući u obzir raznolikost posebnih perspektiva pojedinaca. Opravdanje postižemo kada imamo konvergenciju svih razloga koji su relevantni za različite pojedince. Pluralizam poštujemo i šire od Gausa. Gausov model zahtjeva isključenje onih djelatnika koji nemaju sposobnosti posjedovanja moralnih reaktivnih emocija. S druge strane, naš je cilj zahvatiti širi pluralizam koji je određen raznolikošću kognitivnih i emocionalnih ljudskih moći. 	Metodu javnoga opravdanja primjenjujemo na određenje relevantnih evaluativnih standarda i sposobnosti u područje psihijatrije, na primjerima iz spektra autizma i antisocijalnih poremećaja osobnosti.]]></summary_hr><summary_en><![CDATA[The intention of the project, within political philosophy, is to develop a theory of justification for public evaluative standards that respects the perspectives of all individuals in the context of pluralism, to align it with a capability approach, and to apply it in some relevant cases. Evaluative standards are the criteria by which we judge moral rules, principles of fairness, character traits, and personal and social conditions. We achieve the goal of the project by retaining the inspiration from John Rawls&#39;s thought that public evaluative standards are not legitimate if justified by reasons valid to only some individuals. Yet, unlike Rawls, we do not see a solution in justification that refers solely to individuals&#39; powers of rationality and reason. We bring moral attention to all persons and their perspectives, regardless of emotional and cognitive diversity. We achieve this by being by Martha Nussbaum, according to whom moral status and attention should also be given to individuals who are not rational and reasonable, with their relevant capabilities being guaranteed or supported. We establish a theoretical connection between these two models by retaining inspiration from Gaus who insists public evaluation standards should be justified by a strong adherence to pluralism, taking into account the diversity of specific perspectives of individuals. We achieve justification when we have a convergence of all reasons that are relevant to different individuals. We respect pluralism even more broadly than Gauss. The Gausian model requires the exclusion of those individuals who do not have the capacity to possess moral reactive emotions. Secondly, our goal is to embrace a broader pluralism that is determined by the diversity of cognitive and emotional human powers. We apply the public justification method to the determination of relevant evaluative standards and abilities within the field of psychiatry; in cases of autism spectrum and antisocial personality disorders.]]></summary_en></project><project>
<id>14734</id><title_hr><![CDATA[ Novi modeli oštetljivosti tipičnih zgrada u urbanim područjima: primjene pri procjeni seizmičkog rizika i metodologiji ciljanih ojačanja]]></title_hr><title_en><![CDATA[]]></title_en><user_id>12842</user_id><user_firstLast_name>Mario Uroš</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-2478</code><acronim><![CDATA[2BESAFE]]></acronim><duration>25.10.2021 - 24.10.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Građevinarstvo, </scie_field_hr><scie_field_en>Civil engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Građevinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Civil Engineering]]></institution_en><team_members_id>865121</team_members_id><team_members_names><![CDATA[ Doktorand: Romano Jevtić Rundek ]]></team_members_names><keywords_hr><![CDATA[seizmički hazard, krivulje ranjivosti, krivulje oštetljivosti, složeni numerički proračuni, mehanizam otkazivanja, ciljano ojačanje, seizmički rizik]]></keywords_hr><keywords_en><![CDATA[seismic hazard, fragility curves, vulnerability curves, complex numerical analyses, collapse mechanism, target retrofit, seismic risk]]></keywords_en><summary_hr><![CDATA[Rizik od potresa je jedna od gorućih tema u Jugoistočnoj Europi, no djelovanje zajednice usmjereno na smanjenje posljedica potresa je vrlo ograničeno. Nedavni potresi u regiji su pokazali da posljedice potresa mogu biti katastrofalne. Kroz rad na procjenama rizika od katastrofa, identificirani su ključni problemi koji proizlaze iz neprikladnih ili nepostojećih modela oštetljivosti tipičnih zgrada u urbanim područjima. Predloženim istraživanjem će se donijeti nove i unaprijediti postojeće metode za cjelovito definiranje i opisivanje ponašanja konstrukcija pri djelovanju potresa. Fokus projekta će biti na tipovima zgrada za koje se procjenjuje da će biti najugroženije pri djelovanju potresa, značajno su nastanjene, a ujedno predstavljaju značajan dio fonda građevina urbanih područja u regiji. Provedbom projekta će se definirati seizmički hazard ovisno o seizmotektonskim uvjetima te će se formirati baza zapisa ubrzanja temeljnog tla. Primjenom suvremenih numeričkih metoda proračuna planira se sustavno opisati složene mehanizme otkazivanja odabranih konstrukcija, razviti nove modele vjerojatnosti oštećenja (ranjivosti) i oštetljivosti koji ne postoje u znanstvenoj literaturi te u konačnici razviti novu metodologiju za ciljano (optimalno) ojačanje najugroženijih tipova zgrada. Opisani sveobuhvatni pristup problemu otvara nove teme suradnje među znanstvenicima iz različitih područja stoga je za ostvarenje ciljeva formirana interdisciplinarna istraživačka skupina mladih znanstvenika. Svjesni važnosti i složenosti problematike, tim mladih znanstvenika je podržan i savjetovan od vodećih autoriteta u istraživačkom području iz Hrvatske, ali i iz međunarodnih centara znanja, uključujući mlade hrvatske znanstvenike u inozemstvu. Time bi se uspostavio centar izvrsnosti za napredne ocjene seizmičkog ponašanja i ojačanja zgrada što je neophodno za budući razvoj cjelovitog i pouzdanog modela seizmičkog rizika za regiju, te strategija za umanjenje posljedica.]]></summary_hr><summary_en><![CDATA[Seismic risk should be among key priorities in South-Eastern Europe, but activities of the community to its reduction are very limited. Recent earthquakes in the region have demonstrated that earthquake consequences may be disastrous. Crucial problems resulting from inadequate or non-existing vulnerability models of typical buildings in urban areas have been identified through research efforts on risk assessments. In the scope of the proposed project, new methods will be developed and existing ones enhanced, necessary for a complete definition and description of seismic structural performance. The project will focus on building types with expected high seismic vulnerability, which represent a significant part of the urban building stock in the region. In project implementation, seismic hazard, depending on the seismotectonic conditions, will be defined and database of ground acceleration records formed. It is planned to systematically describe complex collapse mechanisms of the selected structures, develop new fragility and vulnerability models which do not exist in scientific literature and finally, to develop a new methodology for target (optimal) retrofitting of the most vulnerable building types. The described comprehensive approach to the problem opens new topics for collaboration among scientists from different fields. Therefore, an interdisciplinary research group of young scientists is being established for the accomplishment of the project goals. Aware of the importance and complexity of the problem, the team of young researchers is supported and advised by leading authorities in the research field from Croatia, but also from international knowledge centres, including young Croatian scientists abroad. This would establish a centre of excellence for advanced assessments of seismic performance and retrofit of buildings, necessary for the future development of a complete and reliable seismic risk model for the region, as well as strategies for risk mitigation.]]></summary_en></project><project>
<id>14736</id><title_hr><![CDATA[Razvoj i naslijeđe viteških redova u Hrvatskoj]]></title_hr><title_en><![CDATA[]]></title_en><user_id>25921</user_id><user_firstLast_name>Juraj Belaj</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-8083</code><acronim><![CDATA[milOrd]]></acronim><duration>01.09.2021 - 31.03.2026</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Arheologija, </scie_field_hr><scie_field_en>Archeology, </scie_field_en><institution_hr><![CDATA[Institut za arheologiju]]></institution_hr><institution_en><![CDATA[Institute of Archaeology in Zagreb]]></institution_en><team_members_id>29078</team_members_id><team_members_names><![CDATA[ Doktorand: Tea Kokotović ]]></team_members_names><keywords_hr><![CDATA[Viteški redovi, templari, ivanovci, baština, sakralna arhitektura, fortifikacijska arhitektura, grobni nalazi, antropološke analize	]]></keywords_hr><keywords_en><![CDATA[Military orders, Templars, Hospitallers, heritage, sacral architecture, fortification architecture, grave finds, anthropological analysis]]></keywords_en><summary_hr><![CDATA[Predloženim se projektom namjerava interdisciplinarno istražiti templare i ivanovce u Hrvatskoj, prateći njihov razvoj i mijene njihovih lokaliteta. Proučavat će se transformacije različitih pokretnih i nepokretnih nalaza i uzoraka na sljedećim lokalitetima: Gora, Ivanec, Sv. Martin na Prozorju, Gradišče kod Margečana, Pakrac, Račeša i Vrana. U obzor istraživanja ući će i ostali sačuvani objekti viteških redova te muzeji i arhivi. Ciljevi se namjeravaju postići usporednim istraživanjima i analizama na više razina: povijesnih i povijesno-umjetničkih izvora, arheoloških nalaza, uzoraka tla i ljudskih kosturnih ostataka. Odabrani uzorci bit će podvrgnuti radiokarbonskoj analizi te analizi stabilnih izotopa dušika i ugljika. Temeljna pitanja na koja će se komparativnom metodom tražiti odgovori su: mogu li se na temelju povijesnih, arheoloških, biološko-antropoloških i arheobotaničkih podataka, kao i na ostacima graditeljske i umjetničke građe, ustanoviti inovacije za koje se pretpostavlja da su ih viteški redovi donijeli u promatrane krajeve te kako su time utjecali na kvalitetu života svojih podložnika? Tijekom predloženog projekta planira se zapošljavanje doktoranda/ice čija će tema biti usko povezana s temom projekta. Diseminacija znanja planirana je tijekom čitavog trajanja predloženog projekta putem javnih predavanja, izlaganja na kongresima, objavljivanja radova u znanstvenim časopisima, organiziranja međunarodne konferencije, postavljanja izložbe te objavljivanja e-monografije s rezultatima projekta. Informacije o poduzetim aktivnostima bit će kontinuirano objavljivane na mrežnim stranicama projekta. Predloženim projektom produbit će se dosadašnje spoznaje te steći nove o slabo istraženim viteškim redovima na ovome prostoru: povećat će se uvid u količinu i kvalitativne značajke njihovih materijalnih tragova, u njihov utjecaj na lokalne zajednice i lokalnu kulturu, u mijene viteških redova i njihovih lokaliteta te će se jasnije moći definirati njihova ostavština.]]></summary_hr><summary_en><![CDATA[The goal of the proposed project is to conduct an interdisciplinary research of the military orders in Croatia by observing their development and changes on their sites. Transformations of various finds and samples will be studied on the following sites: Gora, Ivanec, St Martin-Prozorje, Gradišče-Margečan, Pakrac, Račeša and Vrana. Other preserved structures of the military orders will also be included in the research as well as museums and archives. The plan is to reach the goals by parallel research and analyses on several levels: of archaeological, historical and art historical sources, samples of soil and human skeletal remains. Selected samples will be subjected to radiocarbon analysis and stable carbon and nitrogen isotope analysis. We will try to answer the following question by means of comparative method: Can the innovations which are presumed to be brought to the observed areas by the military orders and their influence on the life of their subjects be identified based on historical, archaeological, biological anthropological and archaeobotanical data and the remains of architecture and artwork? In the course of the proposed project, employment of a doctoral student is planned, whose theme will be closely related to the theme of the project. Dissemination of knowledge is planned via public lectures, presentations at conferences, papers in scientific journals, organising an international conference, mounting an exhibition and publishing an e-monograph with project results. Information on the conducted activities will be continuously posted on the website. The proposed project will deepen the existing and provide new insights on the scarcely researched military orders in this area: it will expand our knowledge about the quantity and qualitative features of their material remains, their influence on local communities and local culture and about the transformations of military orders and their sites, thereby enabling us to define their heritage more clearly.]]></summary_en></project><project>
<id>14738</id><title_hr><![CDATA[Nedavno odobren HRZZ projekt ”Uloga mikrobiote u razvoju raka mokraćnog mjehura” (IP-2020-02-8921) ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5769</user_id><user_firstLast_name>Janoš Terzić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-2457</code><acronim><![CDATA[]]></acronim><duration>01.10.2021 - 01.10.2025</duration><status>Prekinut</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Split School of Medicine]]></institution_en><team_members_id>865122</team_members_id><team_members_names><![CDATA[ Doktorand: Dora Knezović ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>14739</id><title_hr><![CDATA[Razvoj Greyp platforme za mikromobilnost – GMP]]></title_hr><title_en><![CDATA[]]></title_en><user_id>18915</user_id><user_firstLast_name>Mario Cifrek</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-9585</code><acronim><![CDATA[]]></acronim><duration>01.10.2021 - 30.09.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>865102</team_members_id><team_members_names><![CDATA[ Doktorand: Antonio Stanešić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>14740</id><title_hr><![CDATA[Potraga za kvantnim prostorvremenom u spektru KNM za crne rupe i bljeskovima gama zraka]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1153</user_id><user_firstLast_name>Anđelo Samsarov</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-1934</code><acronim><![CDATA[]]></acronim><duration>01.02.2022 - 01.08.2026</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>865273</team_members_id><team_members_names><![CDATA[ Doktorand: Nikola Herceg ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>14741</id><title_hr><![CDATA[Mitohondrijske podpopulacije i UPRmt u dijabetičkoj kardiomiopatiji]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6752</user_id><user_firstLast_name>Filip Sedlić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-4801</code><acronim><![CDATA[SweetMitochondria]]></acronim><duration>01.11.2021 - 31.10.2025</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Clinical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>865168</team_members_id><team_members_names><![CDATA[ Doktorand: Vid Mirošević ]]></team_members_names><keywords_hr><![CDATA[mitohondriji, srčano zatajivanje, UPRmt, oksidativni stres, dijabetes]]></keywords_hr><keywords_en><![CDATA[mitochondria, failing heart, UPRmt, oxidative stress, diabetes]]></keywords_en><summary_hr><![CDATA[Mitochondrijska disfunkcija igra važnu ulogu u dijabetičkoj kardiomiopatiji. Mitohondrijski odgovor na nesmotane proteine (UPRmt) je jedan od ključnih mehanizama uključenih u regulaciju ispravne mitohondrijske funkcije. Uloga UPRmt-a nije istražena u dijabetičkoj kardiomiopatiji. Ovaj je prijedlog osmišljen kako bi istražio ulogu UPRmt-a u dijabetičkoj kardiomiopatiji, fokusirajući se na predloženi molekularni prekidač Yme1L-Oma1.Naši preliminarni podatci pokazuju da visoka razina glukoze smanjuje izražaj proteina Yme1L, okidača i efektora UPRmt-a. mitoTEMPO, antioksidans usmjeren na mitohondrije vraća ekspresiju proteina Yme1L. To ukazuje na uključenost ROS-a u smanjenju Yme1L-a visokom glukozom. Preliminarni podatci također pokazuju da visoka razina glukoze ubrzava otvaranje mPTP-a i povećava proizvodnju ROS-a.Naši će pokusi biti provedeni na izoliranim kardiomiocitima, srcima štakora s dijabetesom i ljudskom miokardu sa znakovima zatajivanja. Uloga UPRmt-a u dijabetičkoj kardiomiopatiji istraživat će se na nekoliko načina. Testirat ćemo izražaj UPRmt markera i predloženi molekularni prekidač koji regulira aktivaciju UPRmt-a pomoću qPCR-a i western blota. Otvaranje mPTP-a i stvaranje ROS-a testirat će se konfokalnom mikroskopijom, dok će stanična apoptoza i mitohondrijski kalcij biti testirani fluorimetrijskim pristupom. Vrijeme otvaranja mPTP-a i stvaranje ROS-a također će se analizirati u prethodno identificiranim mitohondrijskim podpopulacijama, subsarkolemalnim i interfibrilarnim mitohondrijima. Stupanj oštećenja srca bit će testiran imunopatohistološki. Primijenit ćemo prekomjerni izražaj Yme1L-a i utišavanje Oma1 te tretman s mitoTEMPO-om s ciljem obnavljanja Yme1L-Oma1 balansa, obnavljanja UPRmt-a i ublažavanja dijabetičke kardiomiopatije. ]]></summary_hr><summary_en><![CDATA[Mitochondrial dysfunction plays important role in diabetic cardiomyopathy. Mitochondrial unfolded protein response (UPRmt) is one of key mechanisms involved in regulation of proper mitochondrial function. However, the role of UPRmt is not investigated in diabetic cardiomyopathy. This proposal is designed to investigate the role of UPRmt in diabetic cardiomyopathy, focusing on the proposed Yme1L-Oma1 molecular switch.Our preliminary data show that high glucose downregulates Yme1L protein, a trigger and effector of UPRmt. mitoTEMPO, a mitochondria-targeted antioxidant restores Yme1L protein expression. This indicates involvement of ROS in glucose-induced Yme1L downregulation. Preliminary data also show that high glucose accelerates mPTP opening and increases ROS generation. Our experiments will be conducted on isolated cardiomyocytes, diabetic rat hearts and failing human myocardium. The role of UPRmt in diabetes-induced cardiomyopathy will be investigating by several approaches. We will be testing the expression of UPRmt markers and proposed molecular switch that regulates activation of UPRmt by qPCR and western blot. mPTP opening and ROS generation will be tested by confocal microscopy, while cell apoptosis and mitochondrial calcium will be testes by fluorimetric approaches. The mPTP opening time and ROS generation will be also analyzed in previously identified mitochondrial subpopulations, subsarcolemmal and interfibrilar mitochondria. The extent of heart damage will be tested immunopathohistologically. We will apply Yme1L overexpression, Oma1 silencing and mitoTEMPO treatment to restore Yme1L-Oma1 balance, restore UPRmt and ameliorate diabetic cardiomyopathy.]]></summary_en></project><project>
<id>14742</id><title_hr><![CDATA[Twinning Open Data operational – TODO]]></title_hr><title_en><![CDATA[]]></title_en><user_id>25583</user_id><user_firstLast_name>Ana Kuveždić Divjak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-6535</code><acronim><![CDATA[]]></acronim><duration>15.11.2021 - 14.11.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Geodezija, </scie_field_hr><scie_field_en>Geodesy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Geodetski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Geodesy]]></institution_en><team_members_id>865177</team_members_id><team_members_names><![CDATA[ Doktorand: Andrea Miletić Miletić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>14743</id><title_hr><![CDATA[Modeli i prakse globalne i kulturne razmjene i pokret Nesvrstanih zemalja. Istraživanja prostorno-vremenske kulturne dinamike ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4649</user_id><user_firstLast_name>Tamara  Bjažić Klarin</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-7344</code><acronim><![CDATA[GLOB_Exchange]]></acronim><duration>10.09.2021 - 09.03.2026</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Povijest umjetnosti, </scie_field_hr><scie_field_en>Art history, </scie_field_en><institution_hr><![CDATA[Institut za povijest umjetnosti]]></institution_hr><institution_en><![CDATA[Institute of Art History, Zagreb]]></institution_en><team_members_id>865082</team_members_id><team_members_names><![CDATA[ Doktorand: Martina Bobinac Bobinac ]]></team_members_names><keywords_hr><![CDATA[digitalna povijest umjetnosti, kulturna razmjena, Pokret nesvrstanih zemalja, modernizam, dekolonizacija, virtualna realnost, vizualizacija mreža]]></keywords_hr><keywords_en><![CDATA[digital art history, cultural exchange, Non-aligned Movement, modernism, decolonization, virtual reality, network visualization]]></keywords_en><summary_hr><![CDATA[Predloženi projekt usmjeren je istraživanjima modela međunarodne kulturne razmjene nakon 1960-ih godina. Njegova je hipoteza da su ubrzani procesi dekolonizacije tijekom toga desetljeća, uokvireni artikulacijom kulturnih potreba i kulturnim politikama afričkih, azijskih i latinoameričkih zemalja tek oslobođenih kolonijalne vlasti, rezultirali novim institucionalnim mehanizmima i novim modelima / praksama kulturne razmjene, koji su radikalno narušili dinamiku globalnog kulturnog i umjetničkog polja. Ovakav pristup dovodi u pitanje ideju kronoloških, linearnih tokova dominantnih kulturalnih, umjetničkih i političkih narativa. S promjenom dinamike i institucionalne konfiguracije globalnog kulturnog polja mijenjali su se i modeli kulturalnog prevođenja, a navedene promjene dokumentirat će se usporednom analizom kulturnih politika, organizacijskih metoda, tipova i medijskih formata kulturne razmjene Istočnog bloka, zapadne Europe, SAD-a i zemalja Pokreta nesvrstanih (Jugoslavije, Alžira, Tunisa, Ghane, Indije, Kube itd.). Pritom ćemo se posebno baviti zahtjevima 1960-ih i 1970-ih godina za etničkom, rasnom i rodnom emancipacijom, artikuliranim u polju vizualne kulture i umjetnosti, te načinima njihova posredovanja kroz oficijelne programe kulturne razmjene. S obzirom da je u fokusu projekta transnacionalna, globalna cirkulacija predmeta, osoba i ideja, drugi njegov važan cilj je razviti eksperimentalna, inovativna digitalna sučelja za dinamične prikaze kauzalnih odnosa među podatcima, te za multidimenzionalne mrežne vizualizacije koja će, zahvaljujući neposrednom &#39;uranjajućem&#39; iskustvu bivanja &#39;u podacima&#39;, nesumnjivo utjecati na ono što s njima činimo i na način na koji razumijevamo njihovu spoznajnu vrijednost. ]]></summary_hr><summary_en><![CDATA[The proposed project focuses on the research of the models of international cultural exchange after the 1960s. The hypothesis is that accelerated decolonization processes taking place in that decade, framed by the articulation of cultural needs and the cultural policies of African, Asian and Latin American countries, recently liberated from the colonial government, resulted in a new institutional mechanisms and new cultural exchange models / practices that radically disrupted the dynamics of the global cultural and artistic field. Such perspective challanges the notion of chronological, linear flows of dominant cultural, artistic and political narratives. Along with the change in the dynamics and institutional configuration of the global cultural field, models of cultural translation were also modified. These changes will be documented by a comparative analysis of cultural policies, organizational methods, types and media formats of cultural exchange among the countries of the Eastern Bloc, Western Europe, USA and countries of the Non-Aligned Movement (Yugoslavia, Algeria, Tunisia, Ghana, India, Cuba, etc.). We will thereby particularly address the demands of the 1960s and 1970s for ethnic, racial, and gender emancipation, articulated in the field of visual culture and arts, and ways of their mediation through official cultural exchange programs. Given that the project focuses on transnational, global circulation of objects, persons, and ideas, its second important objective is to develop experimental, innovative digital interfaces for dynamic representations of causal relationships between data, and for multidimensional network visualizations that, owing to an immediate &#39;immersive&#39; experience of being &#39;in the data&#39;, undoubtedly influence how we operate with them and the way in which we understand their cognitive value.]]></summary_en></project><project>
<id>14744</id><title_hr><![CDATA[Motorički učinci klostridijskih neurotoksina u središnjem živčanom sustavu]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4022</user_id><user_firstLast_name>Ivica Matak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-6169</code><acronim><![CDATA[MEFCLO]]></acronim><duration>01.11.2021 - 30.04.2026</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>865164</team_members_id><team_members_names><![CDATA[ Doktorand: Patrik Meglić ]]></team_members_names><keywords_hr><![CDATA[klostridijski neurotoksini, neurološki poremećaji pokreta, mišićna hiperaktivnost, središnje motorne regije, središnje djelovanje]]></keywords_hr><keywords_en><![CDATA[clostridial neurotoxins, neurological movement disorders, muscle hyperactivity, central motor regions, central action]]></keywords_en><summary_hr><![CDATA[Klostridijski neurotoksini poput tetanus toksina (TeNT) i botulinum toksina tipa A (BoNT/A) su jedni od najpotentnijih bioloških toksina, te uzročnici simptoma tetanusa i botulizma. Terapijski, male doze BoNT/A se koriste za liječenje hiperkinetskih poremećaja pokreta i spasticiteta, međutim, naša preliminarna istraživanja pokazuju da bi se važan dio njegova utjecaja na abnormalno povećan mišićni tonus moglo odvijati u središnjem živčanom sustavu. Predloženi projekt obuhvaća karakterizaciju novih pretkliničkih modela hiperkinetskih poremećaja pokreta, te karakterizacije učinka BoNT/A. Cilj istraživanja je pomoću vrlo malih doza i volumena TeNT i BoNT/A primijenjenih periferno u mišić ili u određene regije središnjeg živčanog sustava izazvati disbalans u ekscitacijskoj i inhibicijskoj neurotransmisiji motornih regija, koje će oponašati hiperkineziju i hipertoniju prisutnu kod spasticiteta ili distonija. U životinja s hiperkinezijom, karakterizirat će se učinci botulinum toksina u ekstrafuzalnim i intrafuzalnim motornim vlaknima, te centralnim neuronima ventralnog roga i moždanog debla. Središnje djelovanje BoNT/A bit će okarakterizirano pomoću intratekalno primijenjenog  BoNT/A-neutralizirajućeg antitoksina. U istraživanjima će se koristiti bihevioralne 2D i 3D videoanalize hoda u normalnih i hiperkinetičkih životinja tretiranih i ne-tretiranih s BoNT/A. Također će se koristiti i motorički testovi održavanja ravnoteže, umora, te otpora zglobova na pasivno savijanje. Učinci toksina će biti okarakterizirani elektromiografskim mjerenjma spinalnih refleksa te analizom ekspresije neurotransmitora i proteinskih markera vezanih uz motoričku transmisiju. Očekivani znanstveni rezultati biti će zanimljivi u polju neurologije kao iskorak u pretkliničkom ispitivanju novih terapijskih pristupa u liječenju poremećaja pokreta te zbog temeljnih saznanja vezanih uz plastičnost senzornomotoričkog sustava i mehanizama utjecaja klostridijskih neurotoksina na središnji živčani sustav.]]></summary_hr><summary_en><![CDATA[Clostridial neurotoxins such as tetanus toxins (TeNT) and botulinum toxins of type A (BoNT /A) are one of the most potent biological toxins, and causative agents of tetanus and botulism. Therapeutically, low doses of BoNT /A are used to treat hyperkinetic movement disorders and spasticity.  Our preliminary studies indicate that an important part of its effect on abnormally increased muscle tone may occur in the central nervous system. Proposed project involves characterization of new preclinical models of hyperkinetic motion disorders, and characterization of the central effects of BoNT/A. The aim of the study is to induce the imbalance of excitatory and inhibitory neurotransmission of motor regions with very small doses and volumes of TeNT and BoNT/A applied into the peripheral muscle, or into certain regions of the central nervous system. This will imitate hyperkinesia and hypertonia present in spasticity or dystonia. In animals with hyperkinesia, the effects of botulinum toxins will be characterized in extrafusal and intrafusal motor fibers, as well as central neurons of the ventral horn and brain stem. Central activity of BoNT/A will be characterized by intrathecally applied BoNT /A-neutralizing anti-toxin.  Behavioral 2D and 3D video analysis of walking in normal and hyperkinetic animals, as well as motor tests of balance, fatigue, and the joint resistance of joints to passive movement will be used to study the BoNT/A effects. The toxin effects will also be characterized by electromyography of spinal reflexes, and analysis of expression of neurotransmitter and proteins involved in motor neurotransmission. In the field of neurology and neuroscience, the expected scientific results will be a step forward in the preclinical study of new therapeutic approaches to the treatment of motion disorders, the basic knowledge about the plasticity of the motor system, and the mechanism of the influence of clostridial neurotoxins on the central nervous system.]]></summary_en></project><project>
<id>14745</id><title_hr><![CDATA[Mikroplastika u vodi; sudbina, ponašanje i uklanjanje]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1122</user_id><user_firstLast_name>Ana Lončarić Božić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-8646</code><acronim><![CDATA[ReMiCRO]]></acronim><duration>01.08.2021 - 31.07.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Kemijsko inženjerstvo, </scie_field_hr><scie_field_en>Chemical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet kemijskog inženjerstva i tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Chemical Engineering and Technology]]></institution_en><team_members_id>865030</team_members_id><team_members_names><![CDATA[ Doktorand: Anamarija Pulitika ]]></team_members_names><keywords_hr><![CDATA[mikroplastika, onečišćivala koja izazivaju zabrinutost, sudbina i ponašanje, obrada voda, ferati, DFT, QSP/AR]]></keywords_hr><keywords_en><![CDATA[microplastics, contaminants of emerging concern, fate and behavior, water treatment, ferrates, DFT, QSP/AR]]></keywords_en><summary_hr><![CDATA[Mikroplastika (MP) je naziv za sitne čestice polimernog materijala (d<5 mm). Zbog svoje rasprostranjenosti i akumulacije u okolišu, MP postaje razlog globalne zabrinutosti. Malo je poznato o utjecaju MP na zdravlje i okoliš, ali razlozi za zabrinutost su: (i) mikro-veličina čini MP lako dostupnom gutanju i unosu u hranidbeni lanac; (ii) MP je dugo prisutna u okolišu zbog postojanosti i otpornosti prema razgradnji; (iii) MP je praktički nemoguće ukloniti kada jednom dospije u okoliš. Zbog visokog sorpcijskog kapaciteta čestice MP postaju vektori za različita onečišćivala u vodi, uključujući teške metale i nova onečišćivala (eng. contaminats of emerging concern, CEC). Dostupna znanja o sudbini i ponašanju MP u vodi te povezanim rizicima, su nedostatna. Ispusti iz uređaja za pročišćavanje otpadnih voda identificirani su kao putevi ulaska i MP i CECova u okoliš, što jasno ukazuje na potrebu primjene naprednih tehnologija obrade u završnom stupnju.Glavni cilj ReMiCRO projekta jest stvaranje novih znanja potrebnih za razumijevanje sudbine i ponašanja MP u vodi u prisutnosti novih onečišćivala te razvoj rješenja za njihovu učinkovitu obradu. ReMiCRO koristi prednosti sinergije naprednih oksidacijski procesa (eng. advanced oxidation processes AOPs) Fentonovog tipa i ferata(VI). AOPi se temelje na aktivnosti in-situ generiranih radikalskih vrsta I pokazali su se djelotvornima za CECove. Visoka oksidacijska moć ferata(VI) popraćena je s koagulacijskim svojstvima željezo(III) oksida/hidroksida koji nastaju u sustavu. Stoga tehnologije obrade temeljene na AOP-ima Fentonovog tipa i feratima(VI) nude rješenje za rastuće probleme MP i CECova u vodi. Primjena kombiniranog eksperimentalnog i računalnog pristupa omogućava razumijevanje i utvrđivanje utjecaja morfoloških svojstava različitih tipova MP na njihove interakcije s CECovima i teškim metalima u vodi, a time i na učinkovitost procesa obrade vode.]]></summary_hr><summary_en><![CDATA[Microplastics (MPs) are small particles (d<5 mm) of polymer materials. Their persistence and widespread accumulation raised a new concern that reached public awareness. Little is known about the impact of MPs on health and environment but associated concerns are: (i) micro-size makes MPs readily available for ingestion and transfer within the food chain; (ii) MPs are present in environment for a long time due to pervasive nature and resistance to degradation; (iii) MPs are practically impossible to remove from the environment after release. MPs display high sorption capacity thus may serve as vectors for pollutants in water, including heavy metals and contaminants of emerging concern (CECs). The knowledge on fate and behavior of MPs in water and associated risks is rather scarce. Effluents from wastewater treatment plants are identified pathways for both MPs and CECs entering aquatic environment, incentivizing the need for advanced final-stage technologies.The main goal of ReMiCRO is to fill the knowledge gap on fate and behavior of MPs in water matrices containing CEC, and to develop effective treatment solution. ReMiCRO aims to leverage synergy of Fenton-based advanced oxidation processes (AOPs) and ferrate (VI) treatment. AOPs are based on activity of in-situ generated radical species, proven to be effective in degradation of recalcitrant pollutants. The high oxidation power of ferrate(VI) is combined with coagulation properties of the ensuing iron(III) oxide/hydroxide. Hence, both Fenton-based AOPs and ferrate(VI) are promising candidates to cope with emerging problem of MPs and CECs in water. Combined experimental and computational approach will be applied to enlighten interactions and to establish correlation between MPs of different types, sizes and morphologies with different CECs and heavy metal, influencing the fate and behavior of MPs and the effectiveness of the water treatment process.]]></summary_en></project><project>
<id>14746</id><title_hr><![CDATA[Pametne usluge usmjerene čovjeku u interoperabilnim i decentraliziranim okolinama Interneta stvari]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4930</user_id><user_firstLast_name>Mario Kušek</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-2774</code><acronim><![CDATA[IoT4us]]></acronim><duration>04.10.2021 - 03.10.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>865126</team_members_id><team_members_names><![CDATA[ Doktorand: Dora Kreković ]]></team_members_names><keywords_hr><![CDATA[Internet stvari (IoT), interoperabilnost, sigurnost, privatnost, tehnologija Blockchain, distribuirana digitalna knjiga, kognitivne usluge]]></keywords_hr><keywords_en><![CDATA[Internet of Things (IoT), interoperability, security, privacy, Blockchain, Distributed Ledger Technology, cognitive services]]></keywords_en><summary_hr><![CDATA[Internet stvari (IoT) je identificiran kao revolucionarna tehnologija koja donosi digitalnu transformaciju u mnoga područja te stvara značajan utjecaj na cjelokupno ljudsko društvo. Omogućava ispreplitanje fizičkog i digitalnog svijeta pomoću umreženih uređaja postavljenih u našu okolinu kojima rukuju korisničke aplikacije i usluge, dok njima upravljaju programske platforme. Međutim, semantička i sintaktička nekompatibilnost postojećih platformi ograničava širenje i bolje prihvaćanje IoT-rješenja u praksi te ih ograničava na određene domene ili ogledne projekte. Projekt IoT4us usvaja i nadograđuje aktualne rezultate proizašle iz projekta H2020 symbIoTe tijekom kojega je razvijena međuopremu otvorenog kôda za interoperabilnost Interneta stvari te je uspostavljen početni ekosustav interoperabilnih IoT-platformi, pokrećući tako novi val inovativnih aplikacija i usluga nad različitim domenama i platformama. IoT4us će nastaviti daljnji razvoj tog ekosustav kako bi stvorio interoperabilnu, decentraliziranu, dinamičnu i sigurnu IoT-okolinu koja čuva privatnost korisnika, a pritom se oslanja na računalne resurse na rubu mreže. IoT4us će u takvim dinamičnim okruženjima omogućiti autonomne i kognitivne IoT usluge usmjerene čovjeku i u skladu s potrebama korisnika. Provedeno istraživanje će pridonijeti nastanku IoT-rješenja sljedeće generacije koja su prikladna za mreže 5G, kroz masovno postavljanje IoT-uređaja s osnovnim ciljem ponude praktičnih i sigurnih aplikacija i usluga za krajnje korisnike koje štite njihovu privatnost. Kroz svoje istraživačke ciljeve, projekt će istražiti sljedeće izazovne teme: interoperabilne, dinamičke, decentralizirane i sigurne IoT-ekosustave namijenjene mrežama sljedeće generacije (uključujući mreže 5G), adaptivne komunikacijske protokole za učinkoviti prijenos podataka, inteligentne i kognitivne metode za IoT, tehnologiju Blockchain i mehanizme za očuvanje privatnosti u okolinama Interneta stvari.]]></summary_hr><summary_en><![CDATA[Internet of Things (IoT) is identified as a disruptive technology which brings digital transformation into many domains and creates significant impact on the overall human society. It enables the interweaving of the physical and digital world by means of networked devices placed in our environment that are operated by end user applications and services, while being managed by software platforms. However, semantic and syntactic incompatibilities of existing platforms are limiting a proliferation and higher adoption of IoT solutions in practice by restricting them to specific domains or pilot projects. The IoT4us project is adopting and building upon cutting-edge results of the H2020 project symbIoTe which has developed the Open Source middleware for IoT interoperability and established an initial ecosystem of interoperable IoT platforms steering a new wave of innovative IoT applications and services across different domains and platforms. IoT4us will evolve this ecosystem further to create interoperable, decentralised, dynamic, secure and privacy-preserving IoT environments that, in addition to cloud resources, also rely on edge/fog computing resources. IoT4us will enable human-centric, adaptive and cognitive IoT services and applications in line with user needs in dynamic environments. The performed research will contribute to the emergence of next-generation IoT solutions adequate for 5G networks and massive deployment of IoT devices with a primarily goal to offer practical, secure and privacy-preserving applications and services. Through its research objectives, the project will investigate the following challenging topics: interoperable, dynamic, decentralized and secure IoT ecosystems for next-generation networks (including 5G), adaptable communication protocols for efficient data transmission, intelligent and cognitive methods for IoT, Blockchain technology and privacy-preserving mechanisms for IoT.]]></summary_en></project><project>
<id>14747</id><title_hr><![CDATA[Derivati harmina kao potencijalni antimalarici]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6174</user_id><user_firstLast_name>Ivana Perković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-2037</code><acronim><![CDATA[CLICKforMALARIA]]></acronim><duration>14.12.2021 - 13.12.2025</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Farmacija, </scie_field_hr><scie_field_en>Pharmaceutical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Farmaceutsko-biokemijski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Pharmacy and Biochemistry]]></institution_en><team_members_id>865248</team_members_id><team_members_names><![CDATA[ Doktorand: Ana Penava ]]></team_members_names><keywords_hr><![CDATA[malarija, harmin, sinteza, antimalarijsko djelovanje, citotoksičnost, studije metabolizma]]></keywords_hr><keywords_en><![CDATA[malaria, harmine, synthesis, antimalarial activity, citotoxicity, metabolic studies]]></keywords_en><summary_hr><![CDATA[Malarija je smrtonosna bolest tropskih i subtropskih krajeva koja se prenosi ubodom komarca, a uzrokovana je parazitima roda Plasmodium. Cjepivo protiv malarije ne postoji, kao ni učinkovito uništavanje prijenosnika malarije. Osim toga, pojava otpornosti vrsta Plasmodium na postojeće lijekove dovodi do neučinkovitosti sadašnje terapije i zahtijeva otkriće lijekova s novim mehanizmima djelovanja. Alkaloidi b-karbolinskog tipa prisutni su u biljkama Peganum harmala i Eurycoma longifolia, koje se više od 2 tisućljeća koriste u tradicionalnoj kineskoj medicini za liječenje malarije i karcinoma. Djelatne supstancije ekstrakta biljke su alkaloidi harmin, harmalin, harmalol i harman. In vitro i in vivo studije pokazale su da harmin posjeduje snažno antimalarijsko djelovanje. Njegov mogući mehanizam djelovanja je inhibicija proteina toplinskog šoka 90 iz P. falciparum, koji je nužan za normalni razvoj parazita i ima važnu ulogu u razvoju rezistencije na postojeće antimalarike. U ovom projektu predviđeno je dizajniranje i sinteza knjižnice spojeva, koji se sastoje od harmina i 1) derivata cimetne kiseline (harmicini), 2) poznatih antimalarika: klorokina i meflokina (harmikini) i 3) ferocena (harmoceni). U sva tri tipa predviđenih spojeva poveznica će biti 1H-1,2,3-triazol, koji se pokazao korisnim u pripravi različitih biološki aktivnih spojeva. Predviđeni spojevi pripravit će se uobičajenim metodama sintetske organske kemije, te korištenjem modernih pristupa, &#39;&#39;click&#39;&#39; kemije i sinteze uz pomoć mikrovalova.Sintetiziranim spojevima ispitat će se antimalarijsko djelovanje in vitro, na eritrocitnu i hepatocitnu fazu plazmodija, te citoksično djelovanje na humane stanične linije. Uz to, provest će se studije metabolizma biološki aktivnih spojeva.Konačni rezultat projekta biti će novi spojevi učinkoviti protiv rezistentnih sojeva roda Plasmodium. Najaktivniji spojevi biti će polazišna točka za budući razvoj inovativnih lijekova.]]></summary_hr><summary_en><![CDATA[Malaria is a deadly mosquito-borne tropical and subtropical disease, caused the parazite of the genus Plasmodium. There is neither available vaccine, nor reliable vector control. In addition, Plasmodium is developing resistance to the existing therapy, which urges the discovery of novel drugs with new mechanisms of action.Alkaloids of b-carboline type are present in the medicinal plants Peganum harmala and Eurycoma longifolia, which have been used in the traditional Oriental medicine for the treatment of cancer and malaria. The active ingredients were identified as harmine, harmaline, harmalol and harman. In vitro and in vivo studies have proven harmine&#39;s antimalarial activity. Its possible mechanism of action is selective inhibition of P. falciparum heat shock protein 90, which is crucial for the parazite development and may play a major role in drug resistance. In the proposed project we decided to focus on the design and synthesis of a compound library, comprising harmine and 1) cinnamic acid moiety (harmicines), 2) known antimalarial drugs: chloroquine or mefloquine (harmiquines) and 3) ferrocene scaffold (harmocenes). The final compounds will incorporate 1H-1,2,3-triazole scaffolds, which proved to be useful in the synthesis of various biologically active compounds. Standard methods of synthetic organic chemistry, as well as modern approaches, such as click chemistry and microwave assisted synthesis will be employed. Antimalarial activity of the prepared compounds will be evaluated in vitro on both erythrocytic and hepatic stage of the Plasmodium, as well as cytotoxycity against human cell lines. In addition, metabolism studies for the biologically active compounds will be performed. As a final result, we will provide new candidate therapeutics against drug-resistant malaria parasite. The most active compounds will offer a valuable starting point for future development of innovative medicines.]]></summary_en></project><project>
<id>14750</id><title_hr><![CDATA[Fleksibilnost mikromreža s visokim udjelom pretvarača]]></title_hr><title_en><![CDATA[]]></title_en><user_id>7001</user_id><user_firstLast_name>Tomislav Capuder</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-8459</code><acronim><![CDATA[FLEXIBASE]]></acronim><duration>22.07.2021 - 21.07.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>865034</team_members_id><team_members_names><![CDATA[ Doktorand: Bojana Barać ]]></team_members_names><keywords_hr><![CDATA[mikromreže, AC/DC pretvarači, relejna zaštita, tržište električne energije, fleksibilnost, laboratorijsko ispitivanje]]></keywords_hr><keywords_en><![CDATA[microgrids, AC/DC converters, relay protection, electricity markets, flexibility, laboratory testing]]></keywords_en><summary_hr><![CDATA[Integracijom brzih punionica električnih vozila, baterijskih spremnika energije, fotonaponskih panela i istosmjernih tereta, povećava se količina mikromreža s visokim udjelom AC/DC pretvarača. Projekt je usmjeren na algoritme upravljanja i zaštite u takvim mikromrežama te na njihovu interakciju s distribucijskim sustavom i tržišnim sudionicima u svrhu monetizacije fleksibilnosti i upravljivosti koje mikromreže s visokim udjelom pretvarača posjeduju. Prvi cilj projekta je razvoj algoritama za estimaciju i maksimizaciju dostupne fleksibilnosti u mikromreži s visokim udjelom pretvarača korištenjem hijerarhijskog upravljanja koje će se temeljiti na dva upravljačka sloja. Gornji upravljački sloj minimizira dugoročne troškove pogona mikromreže, dok donji upravljački sloj osigurava kratkoročno zadovoljavanje tehničkih ograničenja tj. stabilnosti pogona mikromreže u mrežnom i otočnom radu. Na primjenu ovako definiranog upravljačkog koncepta mikromreže nadovezuje se drugi cilj projekta, a to je algoritam za bolju koordinaciju rada zaštitnih uređaja koji će omogućiti pogon mikromreže bliže granicama stabilnosti na temelju mjerenja i prikupljenih podataka. Pogon mikromreže bliže granicama stabilnosti povećava dostupnu fleksibilnost koja će se kroz treći cilj projekta nuditi na tržištima energije i pomoćnih usluga tržišnim sudionicima i operatorima sustava. Naime, tržišni algoritam imat će mogućnost kvantifikacije razine dostupne fleksibilnosti u ovisnosti o trenutnom položaju radne točke i prognozama za budućnost uz optimiziranu koordinaciju rada zaštitnih uređaja mikromreže. Nadalje, s obzirom da je jedna od osnovnih značajki i prednosti mikromreže otpornost na vanjske kvarove, četvrti je cilj projekta razviti model optimalnog pogona mikromreže koja u svakom trenutku može prijeći u otočni pogon uz zadržavanje stabilnosti i napajanja svojih potrošača. Svi razvijeni algoritmi testirat će se i verificirati u stvarnoj laboratorijskoj mikromreži s velikim udjelom pretvarača.]]></summary_hr><summary_en><![CDATA[Integration of fast DC chargers for electric vehicles, battery energy storage, photovoltaics and DC loads results in microgrids with a large share of AC/DC power converters. The project focuses on control and protection algorithms in such microgrids, as well as on their interaction with the distribution system and market participants with the goal of monetizing the flexibility and controllability of the converter-based microgrids. The first goal of this project is to develop algorithms for estimation and maximization of the available flexibility within a converter-based microgrid using the hierarchical control concept based on two layers. The upper control layer minimizes the long-run operational costs, while the lower control layer ensures feasibility of the technical constraints, i.e. microgrid stability both in on-grid and island operation. Application of this control concept is further enhanced with the second project goal, which is the algorithm for improved coordination of relay protection devices that enables microgrid operation closer to its stability limits based on measurements and historical data. Microgrid operation closer to its stability limits increases the available flexibility, which will be offered, in the third goal of this project, in energy and ancillary service markets to the market participants and system operators. The optimal market offering algorithm will be able to quantify the available flexibility within the microgrid considering its current operating point, future forecasts and coordinated operation of protection relays. Finally, since one of the main characteristics and advantages of microgrids in general is resilience to external faults, the fourth project goal is to develop a model of optimal operation model of a converter-based microgrid which can switch to the island operation at any time. All the developed algorithms will be tested and verified in an actual laboratory microgrid based on AC/DC converters.]]></summary_en></project><project>
<id>14752</id><title_hr><![CDATA[National Competence Centres in the framework of EuroHPC (EUROCC)]]></title_hr><title_en><![CDATA[]]></title_en><user_id>28996</user_id><user_firstLast_name>Lado Kranjčević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-7690</code><acronim><![CDATA[]]></acronim><duration>01.11.2021 - 31.10.2025</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Temeljne tehničke znanosti, </scie_field_hr><scie_field_en>Basic engineering sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Tehnički fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Engineering]]></institution_en><team_members_id>865186</team_members_id><team_members_names><![CDATA[ Doktorand: Andro Rak ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>14753</id><title_hr><![CDATA[Istraživanje interakcija između regulatornih varijanti u kontekstu bolesti čovjeka]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4183</user_id><user_firstLast_name>Anja Barešić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-7831</code><acronim><![CDATA[IntRegVar]]></acronim><duration>20.10.2021 - 19.10.2025</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Biotehnologija, </scie_field_hr><scie_field_en>Biotechnology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>865112</team_members_id><team_members_names><![CDATA[ Doktorand: Katarina Prskalo ]]></team_members_names><keywords_hr><![CDATA[regulacija gena, nekodirajuće varijacije, bolest, cjelogenomska asocijacijska istraživanja, regulatorna genomika]]></keywords_hr><keywords_en><![CDATA[gene regulation, non-coding variation, disease, GWAS, regulatory genomics]]></keywords_en><summary_hr><![CDATA[Cjelogenomska asocijacijska istraživanja (GWAS) su moćan alat za otkrivanje čestih varijanti povezanih s bolešću, ali do danas nisu uspjeli riješiti nedostajuće nasljeđe za mnoge bolesti. Glavni problem u rasvjetljavanju novih mehanizama složenih bolesti je posljedica činjenice da je većina GWAS varijanti u nekodirajućim regijama i povezuje ih se s najbližim genima u genomskom prostoru, ignorirajući brojne dokaze o reguliranju gena dugog dometa, što rezultira listama gena minimalnog presjeka između studija te niskim postotkom eksperimentalne validacije.Predloženi projekt adresira taj glavni problem predviđanja ciljnih gena. Prvo, nedavno razvijena metoda bit će usavršena proširivanjem skupa podataka koji se koriste za otkrivanje povezanosti pojačivača i promotora u različitim prostorno-vremenskim kontekstima kod ljudi i raspona varijanti za koje se daju predviđanja. Konačno, koristeći mnoštvo informacija o svim ljudskim bolestima sa značajnom genetskom komponentom, ovaj će se projekt usredotočiti na epistatske interakcije između lokusa.Ovdje predloženi rad će produbiti uspostavljenu međunarodne suradnje, kako s kliničkim istraživačima koji imaju pristup relevantnim podacima o pacijentima, a kasnije i s eksperimentalnim biolozima sa ekspertizom u validaciji nekodirajućih funkcionalnih elemenata u relevantnom modelnom organizmu. Dosadašnje iskustvo u radu s kliničkim znanstvenicima na bolestima poput shizofrenije, makularne degeneracije i ne-sindromskog neurorazvojnog kašnjenja pokazalo je da su alati za automatsko tumačenje javno dostupnih podataka, pretvorbe rezultata u eksperimentalne teze ili sužavanje kandidata za validaciju, i presudno, priopćavanje novih nalaza u kliničarima razumljivom jeziku nužni za ubrzavanje translacijskog napretka u ovom polju. Planiram prenijeti svoje iskustvo rada u multidisciplinarnim timovima i snažno se zalažem za suradnju među različitim poljima, po mogućnosti prenoseći to znanje studentima ako se ukaže prilika.]]></summary_hr><summary_en><![CDATA[Genome-wide association studies emerged as a powerful tool to detect common variants associated with the disease, but up to this date fail to address missing heritability for many diseases. The main issue in elucidating novel mechanisms of complex diseases is due to the majority of GWAS variants being non-coding, and linking them to the closest gene in genomic space ignoring ample evidence of long-range gene regulation, resulting in gene lists with poor reproducibility between the studies and low rates of experimental validation.Proposed project addresses this major caveat in target gene prediction. First, a recently developed method will be refined by extending the range of datasets used to detect enhancer-promoter associations over different spatiotemporal contexts in humans, and the range of variants for which the predictions are made. Finally, utilising a wealth of information on all human diseases with significant genetic component, this project will focus on epistatic interactions between the loci. The work proposed here will ultimately deepen established international collaborations, with both clinical researchers who have access to pertinent patient data, and later experimental biologists with expertise in validation of non-coding functional elements in relevant model organism for human diseases. Previous experience in working with clinical scientists on diseases like schizophrenia, macular degeneration and non-syndromic neurodevelopmental delay indicated that having means to interpret publicly available data in an automated way, translating findings into experiments, or narrowing down candidates for the validation, and crucially, communicating novel findings in form understandable to clinicians is necessary to speed up translational advancements in this field. I am planning to bring my experience in working in multidisciplinary teams and strongly advocate for collaborations across fields, preferably teaching it to students if opportunity arises.]]></summary_en></project><project>
<id>14756</id><title_hr><![CDATA[Okvir za kontrolu i nadzor bespilotnih letjelica]]></title_hr><title_en><![CDATA[]]></title_en><user_id>12678</user_id><user_firstLast_name>Neven Vrček</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-1611</code><acronim><![CDATA[ORKAN]]></acronim><duration>16.01.2023 - 15.01.2027</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Informacijske znanosti, </scie_field_hr><scie_field_en>Information sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet organizacije i informatike]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Organization and Informatics]]></institution_en><team_members_id>865470</team_members_id><team_members_names><![CDATA[ Doktorand: Ahmed Shareef ]]></team_members_names><keywords_hr><![CDATA[provedba zakona, lokalizacija signala, energetski učinkovita komunikacija, autonomne letjelice, jata, dronovi, konstelacija dronova]]></keywords_hr><keywords_en><![CDATA[policy enforcement, signal localization, energy efficient communication, unmammed aeral vehicle, swarm, drone, drone constellation]]></keywords_en><summary_hr><![CDATA[ORKAN je projekt koji istražuju različite okvire politike i definira najbolje prakse u pogledu na stvaranje politike glede sigurnosti i privatnosti. Ne postoji niti jedan set transparentnih pravila u vezi javne uporabe UAV za komercijalne i nekomercijalne svrhe. ORKAN ih definira tako da se mogu primijeniti u bilo kojem pravnom sustavu.Tu je naglasak na provođenje politike gdje ćemo istražiti i definirati protokole, algoritme i tehnologija za lokalizaciju  UAV pilota. Za to ćemo koristiti nasjnovija dostignuća na području za obradu i analizu radio signala. Jedinica za lokalizaciju je čitava UAV konstelacija koja koristi novi energetski učinkovit komunikacijski protokol koji je sastavni dio ovog projekta. Naše rješenje treba prepoznati kontrolni signal uljeza u EM spektru.  Koristeći ovaj signal konstelacija dronova (UAV) će skenirati i lokalizirati pilota. Nakon uspješnog lokalizacije, lokacija pilota je proslijeđena nadležnima.]]></summary_hr><summary_en><![CDATA[ORKAN is a project that investigated various policy frameworks and defines best practices regarding policy making concerning security and privacy. There is no single  and transparent set of rules regarding public use of UAV for commercial and non commercial purposes. ORKAN defines such that can be implemented in any legal system.There is an emphasis on policy enforcement where we will investigate and define protocols, algorithms and technologies for UAV pilot localization. To do that we will utilize state of the art achievements in the field for radio signal processing and analysis. y efficient communication protocol that is a part of this project. Our solution should identify intruder control signal in EM spectrum. Unit for localization is UAV constellation that uses new energUsing this signal constellation of drones will scan and localize the pilot. After successful localization, pilot location is forwarded to law enforcement unit.]]></summary_en></project><project>
<id>14758</id><title_hr><![CDATA[Stvaranje europskih identiteta – hrana, tekstil i metali u željeznom dobu između Alpa, Panonije i Balkana]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3432</user_id><user_firstLast_name>Hrvoje Potrebica</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-8681</code><acronim><![CDATA[IronFoodTexMet]]></acronim><duration>01.11.2021 - 31.10.2025</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Arheologija, </scie_field_hr><scie_field_en>Archeology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>865197</team_members_id><team_members_names><![CDATA[ Doktorand: Luka Drahotusky-Bruketa ]]></team_members_names><keywords_hr><![CDATA[željezno doba, identitet, hrana, tekstil, metali, Alpe, Panonija, Balkan, Kaptol, Dolenjska, Donja Dolina]]></keywords_hr><keywords_en><![CDATA[Iron Age, identity, food, textile, metals, Alps, Pannonia, Balkans, Kaptol, Dolenjska (lower Carniola), Donja Dolina ]]></keywords_en><summary_hr><![CDATA[Ovaj projekt ima za cilj utvrditi formativne elemente identiteta željeznodobnih zajednica na prostoru koji je kao ključna karika povezuje tri velike kulturne zone u Europi: središnju Europu, Sredozemlje i istočnu Europu. Upravo takav položaj čini ovaj relativno mali prostor izuzetno važnim za razumijevanje procesa stvaranja i promjene identiteta u daleko širim europskim okvirima. Iz kompleksa čimbenika koji tvore identitet prapovijesnih zajednica ovaj projekt izdvaja tri: hranu, tekstil i metale. Iako su prve dvije kategorije elementarne životne potrebe, krećemo od hipoteze da način njihova zadovoljavanja predstavlja izbor koji određuje način života željeznodobnih zajednica i stoji u jakoj korelaciji s njihovom percepcijom svijeta i vlastitog identiteta. S druge strane, metali, prvenstveno bronca i željezo, bili su temeljna pokretačka snaga za uspostavu kontakata i komunikaciju između različitih kulturnih skupina što omogućava kulturni transfer i promjene identiteta pojedinih zajednica. Istraživanje ćemo provesti u tri glavna smjera. Za komparativnu studiju materijalne kulture, prvenstveno metalnih predmeta izdvojena su tri ključna nalazišta na ovom prostoru na kojima ćemo provesti sustavnu komparativnu i kontekstualnu analizu: Kapiteljska njiva u Dolenjskoj, Kaptol u Požeškoj kotlini i Donja Dolina na obali Save. Istraživanje tekstila kao kompleksnog društvenog i gospodarskog fenomena temeljit će se na dvije kategorije materijala: neposredni materijalni ostaci tekstila i alati za proizvodnju tekstila. Rekonstrukcijom čitavog procesa, od proizvodnje tekstila, preko izrade tkanina, do rekonstrukcije nošnje dat ćemo osnovne značajke identiteta pojedinih zajednica te ustanoviti je li kategorija kulturnih skupina doista utemeljena na identitetu. Do istog cilja pokušat ćemo doći i rekonstrukcijom proizvodnje, prerade i pripreme hrane, temeljem dostupnih arheobotaničkih ostataka, analize ostataka iz strukture i s površine keramičkih posuda i analiza stabilnih izotopa.]]></summary_hr><summary_en><![CDATA[The aim of the project is to identify formative elements of the identity of Iron Age communities which occupied a region that played a key role in linking three large European cultural areas: Central Europe, Eastern Europe and the Mediterranean. It is precisely its position that makes this region crucial for our understanding of the processes of creation and alteration of identities in European context. Of the multitude of factors making up the identity of prehistoric communities, the project will focus on three: food, textile and metal. Although the first two are basic life needs, our hypothesis is that the way in which those needs are fulfilled reflects a choice which determined the way of life of the Iron Age communities, and is strongly correlated with their perception of the world and of their own identities. On the other hand, metals were driving force behind setting up contacts and communication among diverse cultural groups, which paved the way for cultural transfer and alteration of identities of individual communities. The research will go in three main directions. Three outstanding archaeological sites have been selected for the purpose of a contextual analysis and comparative study of material culture, primarily objects made of metal: Kapiteljska Njiva, Kaptol, and Donja Dolina. The investigation of textile will be conducted on two categories of finds: direct material remains of fabrics, and tools for textile production. The reconstruction of the entire process, spanning from the production of yarn, weaving of cloth, to the reconstruction of costume, will reveal some basic features of the identity of individual communities and determine whether the category of cultural groups is indeed based on identity. To achieve this we will also use reconstruction of the production, processing and preparation of food, using the available archaeobotanic remains, analyses of traces identified within the pottery structure and on its surface, and stable isotope analysis.]]></summary_en></project><project>
<id>14760</id><title_hr><![CDATA[MSCA ITN ‘Joint Training on Numerical Modelling of Highly Flexible Structures for Industrial Applications (THREAD)’; individualni projekt ‘Stable long-term integration of the Cosserat rod problem in large overall motion’]]></title_hr><title_en><![CDATA[]]></title_en><user_id>26544</user_id><user_firstLast_name>Teo Mudrić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-2116</code><acronim><![CDATA[]]></acronim><duration>11.11.2022 - 10.11.2026</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Temeljne tehničke znanosti, </scie_field_hr><scie_field_en>Basic engineering sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Građevinski fakultet u Rijeci]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Civil Engineering]]></institution_en><team_members_id>866593</team_members_id><team_members_names><![CDATA[ Doktorand: Katarina Tutić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>14761</id><title_hr><![CDATA[Određivanje fizikalno-kemijskih svojstava i toksičnosti nanočestica srebra, bakra i plastike kao potencijalno štetnih novih materijala u obalnim vodama]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4961</user_id><user_firstLast_name>Daniel Lyons</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2021-02</proposal_call><code>DOK-2021-02-8966</code><acronim><![CDATA[NANO-EMC2]]></acronim><duration>25.10.2021 - 24.10.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Interdisciplinarne prirodne znanosti, </scie_field_hr><scie_field_en>Interdisciplinary natural sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>865123</team_members_id><team_members_names><![CDATA[ Doktorand: Matea Marelja ]]></team_members_names><keywords_hr><![CDATA[istraživanja mora i ušće rijeke, nanočestica, nanoplastika, kinetika, toksičnost, bioakumulacija, klimatske promjene ]]></keywords_hr><keywords_en><![CDATA[marine and estuarine research, nanoparticle, nanoplastic, kinetics, toxicity, bioaccumulation, climate change]]></keywords_en><summary_hr><![CDATA[Usporedno s rastućom uporabom proizvoda koji sadrže nanočestice, očekuje se značajno povećanje njihovog oslobađanja u okolinu. Mnoga istraživanja vezana za ponašanje i sudbinu umjetno proizvedenih nanočestica (engl. engineered nanoparticles, ENPs) usmjerena su na kopnene vodene sustave (jezera, rijeke i podzemne vode) zbog očekivanja da će se nanočestice oslobođene u okolinu s vremenom razgraditi u tim istim sustavima bez značajnog prijenosa na ostale dijelove okoliša. Međutim, uzimajući u obzir mnoga nastanjena mjesta u obalnim područjima, potencijalno opterećenje velikom količinom nanočestica u ušćima rijeka kao i priobalnim vodama u nadolazećim godinama sve je značajnije. Budući da postoje dokazi da različite nanočestice mogu biti toksične za brojne organizme, posebno osjetljivi bi mogli biti organizmi u ušćima rijeka i u priobalnim područjima. Međutim, dostupne informacije vezane za ponašanje nanočestica u elektrolitima velike ionske jakosti, posebice učinak koji mogu imati njihovi omotači na koloidnu stabilnost, specijaciju i kinetiku, malobrojne su i nedorečene. Nadalje, trenutno postoji veoma malo raspoloživih podataka o međusobnom djelovanju nanočestica s širokim rasponom raznih organizama u bočatoj i obalnoj vodi. Ovaj će projekt istražiti fizikalno-kemijsko ponašanje nanočestica srebra, bakra i polimera/plastike različitih veličina i površinskih omotača, kao potencijalno opasnih materijala u vodenom stupcu bočatih i obalnih voda, uzevši u obzir abiotičke čimbenike kao što su salinitet, pH, koncentracija kisika i otopljena organsku tvar. Standardizirani biokemijski testovi, prilagođeni specifičnim svojstvima i učinku interferencije ENP, koristiti će se za mjerenje širokog raspona indikatora toksičnosti na izabrane organizme od algi i makroalgi do ježinaca, školjkaša i rakova. Ovim projektom omogućit će se po prvi puta cjelokupni pregled ponašanja nanočestica srebra, bakra i plastike u bočatoj vodi kao kompleksnoj zoni prijelaza iz slatkovodne u morsku vodu.]]></summary_hr><summary_en><![CDATA[In parallel with the growing use of nanoparticle-containing products, their release into the environment over the coming years is expected to increase significantly. Much of the research on the behaviour and fate of engineered nanoparticles (ENPs) in the environment has focused on terrestrial aquatic systems (lakes, rivers and groundwater) due to the expectation that ENPs would eventually be degraded in these systems without significant transport to other environmental compartments. However, with many large population centres located in near-coastal areas, the potential environmental load of nanoparticles in estuarine and coastal waters over the coming years is enormous. As there is increasing evidence that various nanoparticles may be toxic to a range of organisms, biota in estuarine and coastal waters may thus be particularly vulnerable. However, available data on how nanoparticles behave in high strength electrolytes, in particular the effect of their coating on colloidal stability, speciation or ion release kinetics are scarce. Further, there is little data on how such aged nanoparticles interact with the wide range of diverse organisms in brackish and coastal waters.This project will investigate the physico-chemical behaviour of silver, copper and polymer/plastic nanoparticles with a range of different sizes and surface coatings, as materials of concern, in brackish and marine waters based on a range of abiotic factors including salinity, pH, oxygen concentration and dissolved organic matter. Standardised biochemical tests, adapted to take into account the specific properties and interference effects of ENPs, will be used to measure a range of toxicity endpoints in selected organisms ranging from algae and macroalgae to urchins, mussels and crabs. The results from this project will provide for the first time a systematic overview of the behaviour of silver, copper and plastic nanoparticles in brackish water as a complex transition zone from fresh to salt water.]]></summary_en></project><project>
<id>14815</id><title_hr><![CDATA[VALORIZACIJA OSTATAKA IZ PRERADE MASLINA POMOĆU MIKROBNOG VIŠEVRSTNOG BIOKATALITIČKOG AGREGATA]]></title_hr><title_en><![CDATA[VALORISATION OF OLIVE MILL WASTE MATERIAL BY MICROBIAL MULTISPECIES BIOCATALYTIC AGGREGATES ]]></title_en><user_id>20413</user_id><user_firstLast_name>Marko Černe</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IPS</proposal_type><proposal_call>2022-02</proposal_call><code>IPS-2022-02-2099</code><acronim><![CDATA[VALOLIVEWASTE]]></acronim><duration>01.11.2022 - 31.10.2025</duration><status>U tijeku</status><financ_value>199.077,16 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, Biotehnologija, </scie_field_hr><scie_field_en>Agriculture, Biotechnology, </scie_field_en><institution_hr><![CDATA[Institut za poljoprivredu i turizam]]></institution_hr><institution_en><![CDATA[Institute of Agriculture and Tourism in Poreč]]></institution_en><team_members_id>6613, 6490, 20387, 865375, 868736, 867413, 870176, </team_members_id><team_members_names><![CDATA[Dean Ban, Josipa Perković, Marija Romić, Aadil Bajoub, QAISER JAVED, MOHAMMED BOUHADI, Abdelaali oulcaid, ]]></team_members_names><keywords_hr><![CDATA[ostaci iz prerade maslina, kompostiranje, sintetička mikrobna zajednica, prostorni raspored mikroorganizama, proizvodi sa dodanom vrijednošću, lignin]]></keywords_hr><keywords_en><![CDATA[olive mill waste, co-composting, synthetic microbial community, spatial distribution of microorganisms, value added products, lignin]]></keywords_en><summary_hr><![CDATA[Povećana potražnja za proizvodnjom maslinovog ulja rezultirala je s više od 30 milijuna m3 otpada poput komine maslina (KM) godišnje u području Mediterana. Fitotoksičnost svježe KM, uzrokovana visokim koncentracijama polifenola, lipida i organskih kiselina, može se smanjiti ili spaljivanjem otpada ili njegovim valoriziranjem. U sklopu ovog projekta istražit ćemo valorizaciju KM pomoću dva pristupa: (i) kompostiranjem s ciljem proizvodnje organskog gnojiva i (ii) biotransformacijom, s ciljem proizvodnje spojeva sa dodanom vrijednošću koji se mogu koristiti u prehrambenoj i farmaceutskoj industriji. Navedeni organski nusprodukt prirodno se sporo biološki razgrađuje zbog niskog sadržaja N, lignoceluloze i antimikrobnih spojeva. Kako bismo ubrzali i usmjerili metaboličke putove za valorizaciju KM, bioaugmentirat ćemo KM s konzorcijima odabranih mikroba umjesto samo jednog soja, budući da je manje vjerojatno da ćemo dobiti jedan generalistički soj koji uključuje sve metaboličke putove potrebne za razgradnju spojeva poput lignoceluloze kao i da budu prilagođeni teškim fizikalno-kemijskim uvjetima. Nasuprot tome, konzorciji zajedno djeluju kao superorganizam koji doprinosi pojedinačnim koracima metaboličkih puteva uključenih u razgradnju i povećava učinkovitost biorazgradnje KM. Sukladno tome, cilj projekta je razviti rješenje temeljeno na sintetičkom konzorciju, sastavljenom od niza različitih specijaliziranih sojeva. Najprije ćemo izolirati i odrediti bakterijske sojeve i konzorcije aktivne protiv komponenti KM. Drugo, aktivnost ovih konzorcija odredit ćemo kroz produkte procesa razgradnje. Nadalje, procesi će se optimizirati mjerenjem dinamike mikrobne zajednice. Konačno, bit će uvedena posebna tehnologija nosača gdje će se najučinkovitija sintetička zajednica imobilizirati i koristiti u pilotskim postavkama kompostiranja gdje će se proces kompostiranja optimizirati. Biološkim testovima ispitat će se fitotoksičnost i gnojidba biljaka zrelog komposta.]]></summary_hr><summary_en><![CDATA[Increased demands for olive oil production result in more than 30mio m3 of wastes such as olive pomace (OP) per year in the Mediterranean basin. The phytotoxic nature of fresh OP, caused by the high concentrations of polyphenols, lipids and organic acids, can be reduced either by burning the waste or by valorising it. Here we will explore valorisation of OP by two approaches: (i) composting, aiming to produce fertilizers and (ii) biotransforming, aiming to produce added value compounds that can be used in food and pharmaceutical industries. The highly organic OP is naturally slowly biodegraded due to low N content, recalcitrant substances and antimicrobial compounds. To speed up and to direct metabolic pathways for valorisation of OP, we are going to bioaugment OP with consortia of selected microbes instead of just one strain, since it is less likely to obtain a single generalist strain that incorporates all the metabolic pathways needed to degrade the recalcitrant compounds as well as to be adapted to the harsh physicochemical conditions. In contrast, consortia collectively act as a superorganism contributing individual steps of the metabolic pathways involved in degradation and increases the effectiveness of OP biodegradation. Accordingly, the aim of the project is to develop a solution based on the synthetic consortium, composed of a set of different specialist strains. Firstly, we are going to isolate and determine bacterial strains and consortia active against components of OP. Secondly, we will determine activity of these consortia through products of the decomposition process. Processes will be optimized through measuring microbial community dynamics. Finally, the specific carrier technology will be introduced where the most efficient synthetic community will be immobilized and used in the pilot-scale composting setups where the composting process will be optimized. The phytotoxicity and plant fertilisation of mature composts will be tested with bioassays.]]></summary_en></project><project>
<id>14818</id><title_hr><![CDATA[Intenzifikacija biokatalitičkih procesa za održivu valorizaciju otpada primjenom eutektičkih otapala u mikroreaktorima ]]></title_hr><title_en><![CDATA[Biocatalytic process intensification using deep eutectic solvents in microflow systems for sustainable waste valorization ]]></title_en><user_id>6126</user_id><user_firstLast_name>Marina Cvjetko Bubalo</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IPS</proposal_type><proposal_call>2022-02</proposal_call><code>IPS-2022-02-3938</code><acronim><![CDATA[BioInDES]]></acronim><duration>01.10.2022 - 30.09.2025</duration><status>Završio</status><financ_value>195.102,53 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Biotehnologija, </scie_field_hr><scie_field_en>Biotechnology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Food Technology and Biotechnology]]></institution_en><team_members_id>3228, 277, 21346, 857311, 866662, </team_members_id><team_members_names><![CDATA[Ivana Radojčić Redovniković, Ivana Varenina, Manuela  Panić, Mia Radović, Anja Damjanović, ]]></team_members_names><keywords_hr><![CDATA[Biokataliza, eutektička otapala, imobilizacija enzima, kontinuirani procesi, intenzifikacija procesa, valorizacija otpada]]></keywords_hr><keywords_en><![CDATA[Biocatalysis, deep eutectic solvents, enzyme immobilisation, flow chemistry, process intensification, waste vaorisation]]></keywords_en><summary_hr><![CDATA[Potencijal biokatalitičkih procesa kao ključne tehnologije održive proizvodnje daleko je od ostvarenja. Glavni izazov ovih procesa vezan je njihova niska produktivnost vezana uz često nisku topljivost supstrata i/ili produkta u vodi te deaktivaciju enzima u organskim otapalima odnosno pri visokim koncentracijama produkta. Primjenom eutektičkih otapala (DESs), nove klase zelenih otapala, moguće je značajno poboljšati topljivost supstrata i smanjiti troškove procesa, potrošnju energije te stvaranje otpada. Stabilizacija biokatalizatora može se postići imobilizacijom biokatalizatora, omogućujući njihovu višekratnu uporabu u sustavima s kontinuiranim protokom. Minijaturizacijom reaktora moguće je postići visoku koncentraciju biokatalizatora, voditi kontinuirane procese te postići izvrstan prijenos mase i topline, a što dovodi do visoke volumetrijske produktivnosti procesa. Štoviše, bolja kontrola procesa u ovakvim sustavima, mogućnost integracije procesa za uklanjanje proizvoda in situ i teleskopiranje multienzimskih reakcija mogu značajno doprinijeti intenziviranju biokatalitičkog procesa. U sklopu projekta razvijat će se kontinuirana biokonverzija CO2 u metanol te furfurala u njegove visokovrijedne derivate pomoću DES-a i imobiliziranih biokatalizatora u kontinuirano vođenim procesima u mikroreaktorima, a koji uključuju multienzimske reakcije uz integrirano uklanjanje produkta. Ovo istraživanje proširit će znanje o biokatalitičkim reakcijama korištenjem DES-ova, a posebno o njihovoj primjeni u mikroreaktorima s ciljem intenziviranja ovih procesa. To će dodatno potaknuti industrijsku primjenu održivih biokatalitičkih procesa u rješavanju problema globalnog zatopljenja i valorizacije otpada, pridonoseći postizanju ciljeva postavljenih Europskim zelenim planom.]]></summary_hr><summary_en><![CDATA[The potential of biocatalytic processes as a key enabling technology for sustainable manufacturing is far from being realized. The main challenge is low process productivity related to typically low substrates and/or products solubilities in water and enzyme deactivation in organic solvents or at high product concentrations. The use of deep eutectic solvents (DESs), an emerging class of green media, can substantially improve solubility and decrease process cost, energy consumption, and waste generation. Stabilization of biocatalysts can be achieved by biocatalyst immobilization, enabling also long-term utilization in continuous flow systems. Reactor miniaturization offers the possibility to obtain high biocatalyst loads, continuous process operation, and excellent mass and heat transport, leading to high biocatalyst and volumetric productivities. Moreover, better process control in microflow systems, the possibility of process integration for in situ product removal, and telescoping of multienzymatic reactions can significantly contribute to biocatalytic process intensification.  With this proposal, we wish to develop continuous bioconversion of CO2 into methanol and of furfural to its high-value derivatives using DESs and immobilized biocatalysts in microflow systems comprising multienzymatic reactions and integrated product removal. Findings originating from this study will extend the knowledge on biocatalytic reactions using DESs and particularly their use in microflow systems aiming to intensify these processes. This will further spur industrial application of stainable biocatalytic processes to address the global warming problem and waste valorization contributing to achieving the targets set by the European Green Deal.]]></summary_en></project><project>
<id>14826</id><title_hr><![CDATA[YO-VID22: Dobrobit mladih i strukture potpore prije, tijekom i nakon COVID-19 pandemije]]></title_hr><title_en><![CDATA[YO-VID22: Youth wellbeing and support structures before, during and after the COVID-19 pandemic]]></title_en><user_id>19790</user_id><user_firstLast_name>Dunja Potočnik</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IPS</proposal_type><proposal_call>2022-02</proposal_call><code>IPS-2022-02-8156</code><acronim><![CDATA[YO-VID22]]></acronim><duration>01.10.2022 - 30.09.2025</duration><status>Završio</status><financ_value>79.726,47 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Sociologija, Psihologija, Interdisciplinarne društvene znanosti, </scie_field_hr><scie_field_en>Sociology, Psychology, Interdisciplinary social sciences, </scie_field_en><institution_hr><![CDATA[Institut za društvena istraživanja]]></institution_hr><institution_en><![CDATA[Institute for Social Research in Zagreb]]></institution_en><team_members_id>22758, 12779, 21232, 11224, 23832, </team_members_id><team_members_names><![CDATA[Anja Gvozdanović, Gordana Kuterovac Jagodić, Iva Odak, Darja Maslić Seršić, Sandra Antulić Majcen, ]]></team_members_names><keywords_hr><![CDATA[mladi, Covid-19 pandemija, dobrobit, strukture socijalne potpore, Hrvatska, Slovenija]]></keywords_hr><keywords_en><![CDATA[youth, Covid-19 pandemic, wellbeing, social-support structures, Croatia, Slovenia]]></keywords_en><summary_hr><![CDATA[Utjecaj pandemije COVID-19 kao izvora brojnih potencijalnih stresnih i rizičnih čimbenika i izazova psihosocijalnom razvoju i dobrobit mladih odnedavno je predmet intenzivnog interesa i rasprava među znanstvenicima, kreatorima javnih politika i široj javnosti. Međutim, postoji tek nekoliko studija o potencijalnim učincima nenormativnih razvojnih iskustava kroz izravnu usporedbu situacija prije, tijekom i nakon pandemije i većina ih se odnosi na adolescente (Hafstad i sur., 2021; Andreas & Brunborg, 2021). Usredotočujući se prvenstveno na dobrobit mladih u Hrvatskoj i Sloveniji, predložena studija će se nadovezati na jedinstvenu priliku za ponovnu primjenu instrumenata koji se koriste za mjerenje različitih aspekata dobrobiti mladih i razvojno relevantnog društvenog okruženja u predpandemijskoj 2018., te tako pouzdanije procijeniti opseg utjecaja pandemije na mlade. Istraživanje će se temeljiti na kombinaciji kvantitativne (anketa i analiza sekundarnih podataka) i kvalitativne (dubinski intervjui, fokus grupe i analiza sadržaja) metode. Ovaj pristup također će omogućiti uvid u funkcioniranje različitih razvojno relevantnih struktura socijalne potpore (obitelj, vršnjaci, obrazovne institucije, socijalne službe, klinike za mlade i organizacije civilnog društva) koje su bile dostupne mladima prije, tijekom i nakon pandemije, kao i uloge tih potpornih struktura u dobrobiti mladih. Takav pristup stvara čvrstu osnovu za razumijevanje mehanizama koji stoje iza identificirane promjene u dobrobiti mladih. Ovo razumijevanje nije samo presudno sa znanstvenog stajališta, već pruža i čvrstu osnovu za identificiranje potencijalno najučinkovitijih mjera javne politike na nacionalnoj i široj europskoj razini. ]]></summary_hr><summary_en><![CDATA[The impact of COVID-19 pandemic as a source of a myriad potential stressful and risk factors and challenges to the psychosocial development andwellbeing of young people has recently been a subject of intense interest and discussions among scholars, policy makers and the general public.However, there are few studies measuring the potential effects of non-normative development experiences through direct comparison of thesituation before, during and after the pandemic and most of them are related to adolescents (Hafstad et al, 2021., Andreas & Brunborg, 2021).Focusing primarily on the well-being of young people in Slovenia and Croatia, the proposed study will build on the unique opportunity to re-apply instruments used for measuring different aspects of youth wellbeing and developmentally relevant social environment in pre-pandemic 2018, andthus more reliably assess the extent of pandemic impacts on young people. The study will be based on a mixed method approach, combiningquantitative (survey and secondary data analysis) and qualitative (in-depth interviews, focus groups and content analysis) methods. This approachwill also enable insight into the functioning of different developmentally relevant social support structures (family, peers, educational institutions,social services, youth clinics and civil society organisations) that were available to young people before, during and after the pandemic, as well asroles of those support structures in young people’s wellbeing. Such an approach creates a solid basis for understanding the mechanisms behind theidentified changes in young people’s well-being. This understanding is not only crucial from the scientific standpoint, but also provides a solid basisfor identifying the potentially most effective policy measures at the national and the wider European levels. ]]></summary_en></project><project>
<id>14832</id><title_hr><![CDATA[Učinak digitalizacije interne komunikacije na zadovoljstvo internom komunikacijom, angažiranost zaposlenika i, posljedično, percipirano zadovoljstvo životom]]></title_hr><title_en><![CDATA[How digitalization of internal communication affects internal communication satisfaction, employee engagement and consequently perceived life satisfaction ]]></title_en><user_id>23352</user_id><user_firstLast_name>Ana Tkalac Verčič</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IPS</proposal_type><proposal_call>2022-02</proposal_call><code>IPS-2022-02-4542</code><acronim><![CDATA[DIGINTCOM]]></acronim><duration>01.10.2022 - 30.09.2025</duration><status>Završio</status><financ_value>100.556,11 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, </scie_field_hr><scie_field_en>Economy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Ekonomski fakultet u Zagrebu]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Economics and Business]]></institution_en><team_members_id>26347, </team_members_id><team_members_names><![CDATA[Anja Špoljarić, ]]></team_members_names><keywords_hr><![CDATA[Interna komunikacija, Percipirana vrijednost kanala, Zadovoljstvo internom komunikacijom, Angažiranost, Zadovoljstvo životom]]></keywords_hr><keywords_en><![CDATA[Internal communication, Perceived channel value, Internal communication satisfaction, Engagement, Life satisfaction]]></keywords_en><summary_hr><![CDATA[Mnogi trendovi u organizacijskom ponašanju ubrzano su zaživjeli kao posljedica pandemije u mnogim organizacijama. Dok prosječni zaposlenik želi polovicu svojeg radnog vremena raditi od kuće, poslodavci se s takvim pristupom poslu ne slažu. Preklapanje privatnog i poslovnog života kao posljedica rada iz „kućnog ureda“ ima, i imat će i dalje, ogromne posljedice. Organizacije, kao i njihovi zaposlenici, morat će uložiti više truda. To će uzrokovati promjene u svim aspektima zaposlenja, ali i još veću podjelu. Doći će i do neizbježnih poboljšanja. Menadžeri će morati bolje komunicirati i prestati očekivati od zaposlenika da do informacija dođu osmozom. S ciljem razumijevanja novih obrazaca u komunikaciji i njihovog učinka na živote zaposlenika, ovaj projekt teži razviti teoriju o preferencijama u internoj komunikaciji i istražiti kako su one povezane s percipiranom vrijednošću digitalnih kanala, kulturom, osobnošću, indikatorima kvalitete društvene razmjene, angažiranošću i zadovoljstvom životom.Projekt ima četiri ključna cilja:1.	Opisati teorijski i konceptualni okvir za procjenu interne komunikacije u razlitčim okruženjima.2.	Pojasniti povezanost stava prema digitalnim komunikacijama i internoj komunikaciji.3.	Predvidjeti potencijalne učinke kulturološke orijentacije i osobina ličnosti na internu komunikaciju i posljedično angažiranost i kvalitetu života.4.	Ponuditi novu teorijsku paradigmu i empirijsku validaciju za unapređenje interne komunikacije. Za ostvarenje postavljenih ciljeva, projekt se sastoji od četiri radna paketa i tri faze prikupljanja podataka (tri eksperimenta, metoda dnevnika i longitudinalna studija u četiri zemlje). ]]></summary_hr><summary_en><![CDATA[Post-pandemic working patterns are going to accelerate many pre-existing trends. The average employee wants to work from home almost half the time, while employers do not share this approach. This overlapping of home and office already has and will continue to have vast consequences. It will force both, organizations, and employees, to raise their game. It will lead to changes in all aspects of work and create bigger divides. It will also bring improvement. Managers will have to communicate better and stop expecting employees to pick up information by osmosis. To understand new patterns of communication and how they affect employees’ lives, this project aims to develop a theory of internal communication preference and explore how it connects perceived digital channel value, culture, personality, social exchange quality indicators, engagement, and life satisfaction. The project has four objectives:1.	Describe a theoretical and conceptual framework for assessment of internal communication in diverse contexts. 2.	Explain the link between digital communication preferences and internal communication. 3.	Predict the potential effect of cultural orientation and personality traits on internal communication and consequently engagement and quality of life. 4.	Provide a new theoretical paradigm and empirical validation to propose change and improvement of internal communication. To accomplish the main research objectives, the project is structured under four work packages with three data collection stages (three experiments, a diary method and a multiwave survey in four countries). ]]></summary_en></project><project>
<id>14837</id><title_hr><![CDATA[Fotokatalitička razgradnja perfluoriranih spojeva u vodi uz Sunčevo zračenje ]]></title_hr><title_en><![CDATA[Solar-assisted photocatalytic degradation of perfluorinated compounds in water]]></title_en><user_id>984</user_id><user_firstLast_name>Hrvoje Kušić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IPS</proposal_type><proposal_call>2022-02</proposal_call><code>IPS-2022-02-4780</code><acronim><![CDATA[SoAPperF]]></acronim><duration>01.11.2022 - 31.10.2025</duration><status>U tijeku</status><financ_value>167.827,99 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Kemijsko inženjerstvo, Interdisciplinarne tehničke znanosti, </scie_field_hr><scie_field_en>Chemical engineering, Interdisciplinary technological sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet kemijskog inženjerstva i tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Chemical Engineering and Technology]]></institution_en><team_members_id>1122, 3651, 1180, 25650, 3168, 867710, 869764, 17765, </team_members_id><team_members_names><![CDATA[Ana Lončarić Božić, Marijana Kraljić Roković, Vladimir Dananić, Josipa Papac, Panaghiotis Karamanis, Suresh Kumar Pandey, Sandra Romac, Marin Kovačić, ]]></team_members_names><keywords_hr><![CDATA[pročišćavanje voda, perfluorirani spojevi, reduktivna razgradnja, fotokataliza, materijali aktivni pod sunčevim zračenjem]]></keywords_hr><keywords_en><![CDATA[water purification, perfluorinated compounds,  reductive degradation, photocatalysis, solar-active materials]]></keywords_en><summary_hr><![CDATA[Zaštita vodnih resursa je prepoznata kao jedan od temelja zaštite okoliša u Europi. Među nizom postojanih onečišćivala koji predstavljaju značajan rizik po vodni okoliš u Europi, perfluorirani spojevi (PFAS), sintetski organski spojevi koji se koriste za dobivanje niza potrošačkih i industrijskih proizvoda, danas predstavljaju jedan od glavnih prioriteta u području kvalitete i obrade voda. Naime, PFASovi predstavljaju poseban izazov prilikom pročišćavanja voda unutar postrojenja koja se oslanjaju na primarnu i sekundarnu obradu te se nameće nužnost uvođenja tercijarnog stupnja obrade. Trenutni fokus je na naprednim fizikalnim te oksidacijsko/redukcijskim procesima, uzimajući u obzir zahtjeve za sekundarnom obradom te energetsku učinkovitost. Stoga se kao potencijalno rješenje za uklanjanje PFASova nameće reduktivna fotokatalitička obrada uz Sunčevo zračenje.Glavni cilj SoAPperF projekta je razvoj fotokatalitičkih materijala za reduktivnu razgradnju PFASova, uzimajući u obzir prednosti unaprjeđenih svojstava poluvodičkih materijala nano-veličine (NSSM) vezano uz smanjenje rekombinacije nosioca naboja te njihove učinkovite aktivacije pod Sunčevim zračenjem. NSSM će se dizajnirati deponiranjem plemenitih metala (Ag) na poluvodičke materijale aktivne pod Sunčevim zračenjem (BiVO4, g-C3N4, N-TiO2, Fe-TiO2, TiO2-WO3) uz prisutnost ko-katalizatora (reducirani grafen-oksid, ugljične kvatne točke). Karakterizacija i evaluacija NSSMa uključuje sveobuhvatnu analizu njihove strukture, površine i sastava, morfologije, kristaliničnosti te poluvodičkih svojstava, dok će se optoelektronička svojstva predvidjeti računalnim kvantno-kemijskim pristupom, što će omogućiti krojenje i unapređivanje NSSMa. Reduktivna razgradnja PFASova uz Sunčevo zračenje će se provoditi u šaržnim i protočnim reaktorima sa imobiliziranim slojem NSSMa, ciljajući na ustanovljavanje mehanizama i putova razgradnje, postavljajući korelaciju sa promjenama u vrijednostima sumarnih pokazatelja kvalitete vode. ]]></summary_hr><summary_en><![CDATA[The protection of water resources is recognized as one of the cornerstones of environmental protection in Europe. Among vast array of persistent pollutants representing a significant risk to or via the European aquatic environment, presence of per- and polyfluoroalkyl substances (PFAS), synthetic organic molecules used to manufacture various consumer and industrials products, is currently set as one of the highest priorities in the field of water quality and treatment. PFAS present a unique challenge for (waste)water treatment plants relying on primary and secondary treatment, thus their upgrade by advanced treatment methods is highly demanded. Current focus is on advanced physical or oxidation/reduction processes, considering also secondary treatment demands and energy efficiency. Accordingly, solar-driven photocatalytic treatment via reduction mechanism seems a promising option for PFAS removal.The main goal of SoAPperF is developing photocatalytic materials for reductive degradation of PFAS, leveraging and improving properties of tailored nano-sized semiconducting materials (NSSMs) to suppress charge carrier recombination and enable their efficient activation under Solar irradiation. NSSMs will be designed by the deposition of noble metals (Ag) onto solar-active materials (BiVO4, g-C3N4, N-TiO2, Fe-TiO2, TiO2-WO3) coupled with carbon-based co-catalysts (reduced graphene-oxide, carbon quantum dots). The characterization and evaluation of NSSM include thorough analysis of their structure, surface and composition, nano-organization and morphology, crystallinity, and semiconducting properties, while optoelectronic properties will be predicted by computational quantum chemical approach, enabling tailoring and back-tailoring of NSSM. Solar-assisted PFAS reductive degradation will be conducted in batch and flow through reactors with immobilized NSSM, aiming at elucidating degradation mechanisms and pathways in relationship to changes in sum-water quality parameters.]]></summary_en></project><project>
<id>14839</id><title_hr><![CDATA[Cirkulirajuće ekstracelularne vezikule kao prediktori antidepresivnog odgovora:  Praćenje mehanizma djelovanja novih terapijskih pristupa u depresiji]]></title_hr><title_en><![CDATA[Circulating Extracellular Vesicles as Predictors of Antidepressant Response: Monitoring the Mechanism of Novel Therapeutic Approaches in Depression]]></title_en><user_id>1023</user_id><user_firstLast_name>Matea Nikolac Perković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IPS</proposal_type><proposal_call>2022-02</proposal_call><code>IPS-2022-02-2497</code><acronim><![CDATA[EVroPAR]]></acronim><duration>01.12.2022 - 20.03.2026</duration><status>U tijeku</status><financ_value>155.285,69 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>13510, 23445, 23632, 3288, 23672, 7272, 865344, 1022, 22640, 29125, 13563, 19784, 19781, 26542, 1306, 1059, 23665, 867368, 867708, 12333, 27627, </team_members_id><team_members_names><![CDATA[Marina Šagud, Sara Medved, Zoran Štimac, Dunja Rogić, Coral Barbas, Darko Marčinko, Filip Mustač, Gordana Nedić Erjavec, Lucija Tudor, Jorge Sáiz Galindo, Maja Bajs Janović, Zoran Bradaš, Biljana Kosanović Rajačić, Ivona Šimunović Filipčić, Nela Pivac, Dubravka Švob Štrac, Marcela Konjevod, Tea Fabijanić Fabijanić, Nikola Balic, Neven Žarković, Matea Kurtović Kodžoman, ]]></team_members_names><keywords_hr><![CDATA[ekstracelularne vezikule, depresija, biomarkeri, antidepresivi, transkranijalna magnetska stimulacija, fototerapija, esketamin, metabolomika, mikroRNA]]></keywords_hr><keywords_en><![CDATA[extracellular vesicles, depression, biomarkers, antidepressants, transcranial magnetic stimulation, phototherapy,  esketamine, metabolomics, microRNA]]></keywords_en><summary_hr><![CDATA[EVroPAR je slovensko-hrvatski multidisciplinarni istraživački projekt koji objedinjuje bazično, predkliničko i kliničko istraživanja, zahvaljujući suradnji Instituta Ruđer Bošković (Hrvatska), Instituta za biokemiju Medicinskog fakulteta u Ljubljani (Slovenija), Sveučilišne zaklade San Pablo CEU (Španjolska), Kliničkog bolničkog centra Zagreb (Hrvatska) i Sveučilišne psihijatrijske klinike Ljubljana (Slovenija). Projekt se oslanja na inovativni pristup istraživanju metaboloma te miRNA profiliranje u svrhu identificiranja novih biomarkera koji bi mogli pomoći u unaprjeđenju individualizacije farmakoterapije u depresiji. Trenutno dostupna terapija za depresiju uključuje farmakoterapiju u kombinaciji s psihoterapijom, a kao česti problem javlja se loš odgovor na terapiju te često prekidanje liječenja od strane pacijenta. Cilj projekta je dati bolji uvid u djelotvornost i molekularne mehanizme djelovanja učestalo korištenog antidepresiva (duloksetina) i usporediti ga s mehanizmom koji stoji iza učinaka alternativnih metoda liječenja u bolesnika s depresijom otpornom na liječenje (transkranijalna magnetska stimulacija (TMS), fototerapija (svjetlosna terapija, BTL), liječenje esketaminom). Projekt će se usredotočiti na cirkulirajuće ekstracelularne vezikule (EV) kao lako dostupne i neinvazivne biomarkere. Cilj je izmjeriti deregulaciju epigenetskih markera, ekspresiju EV miRNA i odrediti metaboličke promjene u četiri skupine pacijenata (duloksetin vs. BLT vs. TMS vs. esketamin), uzorkovanjem 50 pacijenata po skupini prije nakon terapijske intervencije. Drugi cilj je identificirati specifične metaboličke i miRNA profile depresije uspoređivanjem bolesnika s odgovarajućom kontrolnom skupinom (100 ispitanika). Očekujemo da će novo identificirani biomarkeri pomoći u utvrđivanju učinkovitosti terapije u depresiji te predviđanju dobrog ili lošeg odgovor na liječenje, kao ključni korak prema inovativnoj personaliziranoj i učinkovitoj medicini.]]></summary_hr><summary_en><![CDATA[EVroPAR is a Slovenian-Croatian multidisciplinary research project which combines basic, preclinical and clinical research, including partners from Ruđer Bošković Institute (Croatia), Institute of Biochemistry (Faculty of Medicine in Ljubljana, Slovenia), University Foundation San Pablo CEU (Spain), University Hospital Centre Zagreb (Croatia), and University Psychiatric Clinic Ljubljana (Slovenia). Project incorporates cutting-edge metabolomics approach and miRNA profiling in order to identify novel biomarkers that could help clinicians to tailor treatment strategies in depression for individual patients. Currently available therapy for depression involves pharmacotherapy combined with psychotherapy, while dealing with poor response/nonresponse and a frequent discontinuation of treatment. The objective of the study is to give better insights into the efficacy and molecular mechanisms behind the effects of a widely used antidepressant (duloxetine), and compare this to the mechanism behind the effects of alternative methods of treatment in patients with treatment-resistant depression (transcranial magnetic stimulation (TMS), phototherapy (bright light therapy, BTL), esketamine treatment). The study will focus on circulating extracellular vesicles (EVs) as easily obtainable and non-invasive biomarkers. We aim to measure the dysregulation of epigenetic markers, the EV miRNA expression, and to determine metabolic alterations in four groups of patients (duloxetine vs. BLT vs. TMS vs. esketamine), by sampling 50 patients per group before and after the treatment. Another goal is to identify specific metabolic and miRNA signatures of depression by comparing patients with an appropriate control group (100 subjects). We expect that new biomarkers identified in this project will help determine treatment efficiency in depression and predict good/poor response to treatment, as a key step towards the inevitable personalized and effective medicine approach.]]></summary_en></project><project>
<id>14871</id><title_hr><![CDATA[Izolirani ljudi i zajednice u Sloveniji i Hrvatskoj]]></title_hr><title_en><![CDATA[Isolated People and Communities in Slovenia and Croatia]]></title_en><user_id>23268</user_id><user_firstLast_name>Lana Peternel</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IPS</proposal_type><proposal_call>2022-02</proposal_call><code>IPS-2022-02-3741</code><acronim><![CDATA[ISOLATION]]></acronim><duration>01.10.2022 - 30.09.2025</duration><status>U tijeku</status><financ_value>119.107,36 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Etnologija i antropologija, </scie_field_hr><scie_field_en>Ethnology and anthropology, </scie_field_en><institution_hr><![CDATA[Institut za društvena istraživanja]]></institution_hr><institution_en><![CDATA[Institute for Social Research in Zagreb]]></institution_en><team_members_id>6654, 27245, 865372, 828, 866720, 865722, 866719, </team_members_id><team_members_names><![CDATA[Filip Škiljan, Lucija Mihaljević, Hrvoje Čargonja, Ana Perinić Lewis, Jana Žiljak Gršić, Tanja Bukovčan, Nikolina Hazdovac Bajić, ]]></team_members_names><keywords_hr><![CDATA[izolacija, Hrvatska, Slovenija, ruralna i urbana područja, etnografija, zajednice, pojedinci ]]></keywords_hr><keywords_en><![CDATA[isolation, Croatia, Slovenia, rural and urban areas, ethnography, communities, individuals]]></keywords_en><summary_hr><![CDATA[Pandemija Covid-19 stavila je u prvi plan relevantna pitanja, kao što su fizička i društvena izolacija koje su u fokusu ovog projekta. Koristit ćemo antropološki pristup kako bismo prikazali i objasnili što znači biti izoliran. Kroz etnografska istraživanja u izoliranim i napuštenim prostorima pokazat ćemo kako izolacija oblikuje doživljaje izoliranosti i praznine u urbanim i ruralnim područjima među pojedincima i zajednicama u Sloveniji i Hrvatskoj. Također ćemo istražiti kako različiti modaliteti izolacije oblikuju iskustva, vrijednosti i stavove prema okolišu i budućnosti. Specifični ciljevi našeg projekta su: 1. pronaći i usporediti primjere izolacije u Sloveniji i Hrvatskoj; 2. odrediti vrijednosti i stavove unutar i između izoliranih zajednica u različitim kulturnim, povijesnim i društveno-političkim kontekstima; 3. identificirati vrste izolacije koje postoje u udaljenim mjestima i napuštenim krajolicima. Naš glavni znanstveni doprinos bit će konceptualizacija sjećanja, osjeta i osjećaja vezanih uz doživljaj izolacije, udaljenosti i praznine. Štoviše, istaknut ćemo ne samo negativne aspekte izolacije, već i inovativnu moć koja postoji u udaljenim mjestima i izoliranim zajednicama.]]></summary_hr><summary_en><![CDATA[The Covid-19 pandemic has brought several relevant issues to the forefront, including physical and social isolation, which is the focus of this project. We will use an anthropological approach to explain what it means to be isolated. Through ethnographic studies in isolated social spaces and abandoned areas, we will show how isolation shapes the experiences of insularity and emptiness in urban and rural areas among individuals and communities in Slovenia and Croatia. We will also explore how different modalities of isolation shape experiences, values, and attitudes toward the environment and the future. The specific objectives of our project are: 1. to find and compare examples of isolation in Slovenia and Croatia; 2. to determine the values and attitudes within and between isolated communities in different cultural, historical and socio-political contexts; 3. to identify the types of isolation that exist in remote places and abandoned landscapes. Our main scientific contribution will be the conceptualization of memories, sensations and feelings related to the experience of isolation, remoteness and emptiness. Moreover, we will highlight not only the negative aspects of isolation, but also the innovative power that arises in remote places and isolated communities.]]></summary_en></project><project>
<id>14875</id><title_hr><![CDATA[Dinamika i distribucija CO2 u krškoj vadoznoj i epifreatičkoj zoni]]></title_hr><title_en><![CDATA[Dynamics and distribution of CO2 in karst vadose and epiphreatic zone]]></title_en><user_id>3115</user_id><user_firstLast_name>Nenad Buzjak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IPS</proposal_type><proposal_call>2022-02</proposal_call><code>IPS-2022-02-2260</code><acronim><![CDATA[CARDIKARST]]></acronim><duration>01.11.2022 - 31.01.2026</duration><status>U tijeku</status><financ_value>127.891,70 eur</financ_value><scie_area_hr>Interdisciplinarno područje znanosti</scie_area_hr><scie_area_en>Interdisciplinary scientific area</scie_area_en><scie_field_hr>Geografija, </scie_field_hr><scie_field_en>Geography, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>3099, 1413, 865339, 865340, 874033, </team_members_id><team_members_names><![CDATA[Dalibor Paar, Neven  Bočić, Aurel Persoiu, Christos Pennos, Valerija Rossi, ]]></team_members_names><keywords_hr><![CDATA[krš, ugljikov dioksid, tok ugljika, okršavanje, speleogeneza]]></keywords_hr><keywords_en><![CDATA[karst, carbon dioxide, carbon flux, karstification, speleogenesis]]></keywords_en><summary_hr><![CDATA[Ugljikov dioksid (CO2) ima središnju ulogu u trošenju karbonata, dajući krškim vodonosnicima potencijalnu ulogu u globalnoj apsorpciji CO2. Značajan dio krškog podzemlja čini vadozna zona, koja je tek nedavno prepoznata kao bogat rezervoar CO2. U ovom projektu želimo identificirati i kvantificirati procese koji pokreću razmjenu CO2 između vadozne, (epi)freatske zone i atmosfere. Naši rezultati mogu dati novi uvid u globalni ciklus ugljika i speleogenezu. Istraživanje će uključivati monitoring špiljskog zraka, monitoring i uzorkovanje podzemnih voda te usporedbe s vanjskom klimom. Postavit će se mreža automatskih meteoroloških stanica i data logera. Razvit ćemo i implementirati niz jeftinih logera CO2 i temperature baziranih na platformi Arduino s ciljem postizanja veće rezolucije prostornih i vremenskih podataka, te pružanja pristupačnog obrazovnog i istraživačkog alata studentima, istraživačima i upraviteljima zaštićenih područja. U Sloveniji će se mjerenja temeljiti na četiri postojeće meteorološke postaje, uz dodatna dugoročna mjerenja CO2 u zraku i vodi na lokacijama u sustavu Postojnska-Planinska jama i podzemnoj rijeci Pivki. U Hrvatskoj će se sličan pristup primjenjivati u špilji Provali, Gornjoj Baraćevoj špilji i špilji Samograd uključujući špiljske potoke ili obližnje izvore. Do danas je samo jedna studija partnerske grupe u SAD-u pokazala da je brzina otapanja u krškim kanalima jače povezana s ventiliranjem zraka špilja nego s protokom vode. Ovdje ćemo, kombinirajući analizu vremenskih nizova i numeričko modeliranje podzemne ventilacije zraka i transporta CO2, istražiti mehanizme interakcije CO2 s protokom podzemne vode u epifreatskoj zoni. Kvantificirat ćemo tokove ugljika duž podzemnog toka, procijeniti utjecaj na globalni ciklus ugljika i formirati bazu podataka koja će omogućiti bolje razumijevanje krških sustava. Potencijalna primjena u ostalim krškim područjima bit će omogućena meta-analizom podataka o monitoringu špilja diljem svijeta.]]></summary_hr><summary_en><![CDATA[Carbon dioxide (CO2) plays a central part in the weathering of carbonates, giving karst aquifers a potential role of a net global CO2 sink. Significant part of the karst subsurface is the vadose zone, which only recently has been acknowledged as a rich reservoir of CO2. In this project we aim to identify and quantify processes that drive exchange of CO2 between the vadose, (epi)phreatic zone and the atmosphere. Our results may give new insights into the global carbon cycle and speleogenesis. Research will entail cave air monitoring, groundwater monitoring and sampling, and comparisons with outside meteorology. A network of automatic weather stations and data loggers will be installed. We will develop and deploy an array of low-cost CO2 and temperature Arduino based loggers, to achieve higher spatial and temporal data resolution, and to provide students, researchers, and park managers with an affordable educational and research tool. In Slovenia measurements will be based on four existing meteorological stations, and additionally distributed long-term CO2 measurements in air and water at locations in the Postojna–Planina Cave System, following the underground Pivka River. In Croatia similar approach will be followed in Provala Cave, Upper Barač Cave and Samograd Cave including cave streams or nearby springs. To date, only one study by the partner group in the USA has shown how cave ventilation can control the dissolution rate in subsurface streams to a greater extent than discharge rate. Here, by combining timeseries analyses and numerical modelling of subsurface ventilation and CO2 transport, we will investigate the mechanisms of CO2 interaction with groundwater flow in the epiphreatic zone. We will quantify carbon fluxes along underground stream, assess the carbon budget and form a database that will enable better understanding of karst systems. The potential application in other karst areas will be done with a meta-analysis of worldwide cave monitoring data.]]></summary_en></project><project>
<id>14918</id><title_hr><![CDATA[Pouzdanost mjerenja individualnih razlika u rečeničnoj obradi: Međujezična perspektiva]]></title_hr><title_en><![CDATA[Measurement reliability of individual differences in sentence processing: A cross-linguistic perspective]]></title_en><user_id>4359</user_id><user_firstLast_name>Marijan Palmovic</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IPCH</proposal_type><proposal_call>2022-04</proposal_call><code>IPCH-2022-04-3316</code><acronim><![CDATA[MeRID]]></acronim><duration>01.01.2023 - 31.12.2026</duration><status>U tijeku</status><financ_value>108.643,14 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filologija, Interdisciplinarne humanističke znanosti, </scie_field_hr><scie_field_en>Philology, Interdisciplinary humanities, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Edukacijsko-rehabilitacijski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Education and Rehabilitation Sciences]]></institution_en><team_members_id>22784, 20388, 6436, 26179, </team_members_id><team_members_names><![CDATA[Kristina Cergol, Ana Matić Škorić, Melita Kovačević, Eva Pavlinušić Vilus, ]]></team_members_names><keywords_hr><![CDATA[pouzdanost mjerenja, individualne razlike, njemački, hrvatski, češki, danski, mjerenje pokreta očiju, čitanje vlastitim tempom]]></keywords_hr><keywords_en><![CDATA[measurement reliability, individual differences, German, Croatian, Czech, Danish, eye-tracking, self-paced reading, ]]></keywords_en><summary_hr><![CDATA[Ovaj je projekt zamišljen kao studija suvremenih teorijskih i metodoloških pitanja u psiholingvističkim istraživanjima. Krizi repliciranja rezultata, o kojoj se danas raspravlja u psiholingvističkoj literaturi, ali i u psihologiji i kognitivnoj neuroznanosti, pristupit će se upotrebom različitih metoda, proučavanjem individualnih razlika i međujezičnim usporedbama. Temeljit će se na dvjema eksperimentalnim metodama, metodi mjerenja pokreta očiju i metodi čitanja vlastitim tempom, a uključivat će germanske i slavenske jezike. Metoda mjerenja pokreta očiju i metoda čitanja vlastitim tempom upotrijebit će se na dva načina: 1) radi prikupljanja korpusa čitanja u prirodnom okruženju i 2) u eksperimentima koji će omogućiti usporedbe relevantnih psiholingvističkih fenomena (prediktivnost, lokalnost) između jezika i između metoda.Fokus će biti na individualnim razlikama i to i između sudionika i između njih, kao razlika na testu i re-testu. Jezične i nejezične mjere (raspon radnog pamćenja) analizirat će se kako bi se provjerili modeli rečenične obrade.]]></summary_hr><summary_en><![CDATA[This project proposal is envisaged to tackle current theoretical and methodological issues in psycholinguistic research. It will approach the replication crisis, much discussed in psycholinguistic literature, as well as in psychology and cognitive neuroscience, from the angle of the employment of different methods, individual differences between the participants and cross-linguistic comparisons. It will be based on two experimental methods, eye-tracking and self-paced reading and will include Germanic and Slavic languages.Eye-tracking and self-paced reading will be employed in two ways: 1) to collect a corpus of reading sessions in natural settings and 2) in experiments that will enable cross-linguistic and cross-methodological comparisons of psycholinguistically relevant features (predictability, locality). Focus will be put to individual differences, both between the participants and within, as test-retest differences. Linguistic and non-linguistic measures (working memory span) will be analyzed in order to test the sentence processing models.]]></summary_en></project><project>
<id>15013</id><title_hr><![CDATA[Novi pristup praćenja leta i/ili suzbijanja maslinine muhe (Bactrocera oleae, Rossi) uporabom hlapivih tvari nusprodukta proizvodnje piva]]></title_hr><title_en><![CDATA[Novel approach to olive fruit fly (Bactrocera oleae, Rossi) monitoring and/or control using volatile compounds produced by brewing by-product]]></title_en><user_id>4400</user_id><user_firstLast_name>Elda Vitanović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-9643</code><acronim><![CDATA[BeerBy-4-OliveFly]]></acronim><duration>30.12.2023 - 29.12.2027</duration><status>U tijeku</status><financ_value>189.007,01 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Institut za jadranske kulture i melioraciju krša]]></institution_hr><institution_en><![CDATA[Institute for Adriatic Crops and Karst Reclamation in Split]]></institution_en><team_members_id>865624, 3557, 1317, 2882, 21281, 865038, 866263, 869718, 3598, 868736, </team_members_id><team_members_names><![CDATA[Frank Zalom, Katja Žanić, Valerija Dunkic, Marija  Nazlić, Marija Bolčić, Filipa Burul, Walter Leal, Luka Čotić, Mira Radunić, QAISER JAVED, ]]></team_members_names><keywords_hr><![CDATA[Maslinina muha, entomologija, štetnici masline, atraktanti, zaštita bilja]]></keywords_hr><keywords_en><![CDATA[olive fruit fly, entomology, olive pests, attractants, IPM, plant protection ]]></keywords_en><summary_hr><![CDATA[Maslinina muha (Bactrocera oleae Rossi) je ekonomski najznačajniji štetnik masline te svojim prisustvom redovito negativno utječe na količinu i kakvoću ploda i ulja. Godinama je zaštita masline od ove štene vrste bila usmjerena na uporabu pesticida, što je u zadnjih nekoliko desetljeća rezultiralo negativnim učinkom na bioraznolikost i okoliš. Stoga EU nastoji smanjiti upotrebu istih za 50% do 2030. i 100% do 2050. godine. Kako bi se smanjile štete, a ograničila uporaba pesticida, potrebno je iznalaženje učinkovitih nepesticidnih metoda za praćenje leta i/ili suzbijanje B. oleae. Trenutne spoznaje u svijetu govore da različiti otpadni pivski kvasci privlače određene Tephritidae, međutim nije ispitano koje hlapive tvari istih privlače pojedinu štetnu vrstu. Budući da interakcija između B. oleae i otpadnih pivskih kvasaca, nusprodukta proizvodnje piva, te njihovih hlapivih tvari još nije istraživana, ciljevi ovog projekta su ispitati jesu li dva tipa modificiranih otpadnih pivskih kvasaca privlačna B. oleae i ako jesu koje bi hlapive tvari istih mogle biti odgovorne za privlačenje. Ispitat će se i brzina njihovog otpuštanja iz dispenzera u svrhu pronalaska najprivlačnijeg i najučinkovitijeg atraktanta, koji bi se u budućnosti mogao koristiti za praćenje leta i/ili suzbijanje najvažnijeg štetnika masline. Svrha ovog projekta je razvoj nove i učinkovitije metode u zaštiti masline te implementacija njene primjene u maslinarstvo s ciljem smanjenja gubitaka u proizvodnji maslina i maslinovog ulja uzrokovanih napadom gospodarski najznačajnijeg štetnika. Ovaj novi pristup praćenja leta i/ili suzbijanja, mogao bi se primijeniti i na ostale štetne Tephritidae koje uzrokuju velike gubitke na mnogim poljoprivrednim kulturama. Ovim otkrićem bi se Hrvatska zasigurno istaknula kao jedan od lidera zaštite masline među maslinarskim zemljama.]]></summary_hr><summary_en><![CDATA[Olive fruit fly (Bactrocera oleae Rossi) is the most economically important olive pest, and its presence regularly negatively affects the quantity and quality of olive fruit and oil. For years, the control of B. oleae has been based exclusively on pesticides, which in recent decades have had a negative impact on the environment and biodiversity in olive groves. Therefore, the EU has set a target to reduce the use of pesticides by 50% by 2030 and 100% by 2050. To reduce damage and limit pesticide use, effective non-pesticidal methods of olive fruit fly monitoring and/or control are needed. In addition, available lures are not effective enough to control B. oleae in olive groves or in years with high populations. Current evidence suggests that various waste brewer&#39;s yeasts attract certain teprhitids, but it has not yet been studied which of the volatile compounds they produce attract a particular pest species. Because the interaction between B. oleae and waste brewer&#39;s yeasts, a by-product of beer production, and their volatile compounds has not yet been studied, this project will investigate whether two main types of modified waste brewer&#39;s yeasts are attractive to B. oleae and, if so, which volatile compounds may be responsible for the attraction. In addition, the release rates of the volatile compounds from a slow release device will be investigated to find the most attractive and effective lure that could be used in the future to monitor and/or control B. oleae as the most important olive pest. The goal of this project is to develop a new and more effective method to protect olives from the pest and reduce losses in olive and olive oil production due to infestation by the most economically important pest. This new approach could also be applied to other harmful tephritids that cause high losses in many agricultural crops. With this discovery, Croatia would certainly stand out among olive-growing countries as one of the pioneers in the protection of olives.]]></summary_en></project><project>
<id>15019</id><title_hr><![CDATA[Regionalna diferencijacija i laminarni ustroj moždane kore čovjeka: inovativni komparativni pristup]]></title_hr><title_en><![CDATA[Regional differentiation and laminar dynamics of the human cerebral cortex: novel comparative approach]]></title_en><user_id>5534</user_id><user_firstLast_name>Zeljka Krsnik</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-5975</code><acronim><![CDATA[ReDyNovApp]]></acronim><duration>31.12.2023 - 30.12.2027</duration><status>U tijeku</status><financ_value>147.654,13 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>855745, 861731, 25513, 865696, 25528, 868733, 22824, 872995, </team_members_id><team_members_names><![CDATA[Janja Kopić, Alisa Junaković, David Menassa, Parthiv Haldipur, Alvaro Duque, Laura Skukan, Iva Salamon, Gracia Grabaric, ]]></team_members_names><keywords_hr><![CDATA[moždana kora čovjeka, čeona moždana kora, regionalizacija, laminacija, projekcijski neuroni dubokih slojeva korteksa, Tbr1, SOX5]]></keywords_hr><keywords_en><![CDATA[human cerebral cortex, frontal cortex, regionalization, lamination, deep-layers projecting neurons, Tbr1, SOX5]]></keywords_en><summary_hr><![CDATA[Moždana kora čovjeka kao sjedište viših spoznajnih funkcija podjeljena je u strukturno-funkcionalno definirana Brodmannova polja (area). Tijekom ranog prenatalnog razdoblja  najprije dolazi do  podjele moždane kore na regije, prije samog procesa arealizacije. Unatoč impresivnim novim saznanjima u području razvojne neurobiologije, ostaju brojna otvorena pitanja o razvoju ljudske moždane kore, uključujući i fundamentalno pitanje: kada i kako se javljaju prve regionalne razlike moždane kore na molekularnom, staničnom i laminarnom nivou?Stoga smo okupili sljedeće istraživačke resurse i ekspertize: Krsnik (Medicinski fakultet u Zagrebu)– razvoj moždane kore čovjeka; Duque (Yale/MacBrain Resource)- komparativna analiza moždane kore Macaca mulatta; Haldipur (Seattle Children’s Research Institute)- spatial transcriptomics; Menassa (Oxford)-analiza podataka, te Alić (Fakultet Veterinarske medicine)–organoidni model. Testirat ćemo sljedeću hipotezu: ekspresija markera projekcijskih neurona dubokih slojeva moždane kore (DPN) pokazuje regionalne razlike već tijekom ranog fetalnog razvoja, dok se konačni obrasci kortikalnih tipova uspostavljaju tijekom faze formiranja subplate-a.Naši preliminarni rezultati pokazuju da markeri DPN čeone moždane kore pokazuju ranu regionalnu diferencijaciju korteksa (sa 7.5 tjedana nakon začeća). Međutim, najupečatljivija regionalna diferencijacija u čeonom režnju prisutna je u fazi oblikovanja subplate-a u orbitofrontalnom korteksu. Nadalje, laminarna dinamika DPN, zajedno s veličinom subventrikularne zone i načinom oblikovanja subplate zone je nedvojbeni rani pokazatelj regionalne diferencijacije cingularne moždane kore, čak nekoliko mjeseci prije uspostave Brodmannovih area. Stoga, primjenom komparativnog pristupa (čovjek/rezus) i inovativnih tehnologija (&#39;&#39;spatial transcriptomics&#39;&#39;, organoidni model), cilj nam je odgovoriti na fundamentalno pitanje kortikogeneze: kada i kako nastaje rana regionalna diferencijacija moždane kore čovjeka. ]]></summary_hr><summary_en><![CDATA[The human cerebral cortex, a seat of processing higher level cognitive functions, is subdivided into structurally and functionally defined Brodmann areas. The early prenatal regional patterning of cerebral cortex precedes arealization. Despite recent impressive advances in developmental neurobiology, numerous questions remain open, including: how and when regional cortical differences appear at the laminar, cellular and molecular level.To address this question, research team will combine the following expertise/resources: Krsnik (Medical School Zagreb)–human cortical development; Duque (Yale/MacBrain Resource)-comparative Rhesus macaque cortical development; Haldipur (Seattle Children&#39;s Institute)-spatial transcriptomics; Menassa (Oxford)-data analysis and Alić (Faculty of Veterinary medicine, Zagreb)–organoid model.Our team will test following hypothesis: deep-layers projection neurons (DPN) markers show cortex-type specific regional differentiation during early fetal period, but the final pattern of differences between cortical types is established during the subplate formation.In a preliminary study, DPN markers, a pivotal players during corticogenesis,  showed surprisingly early regional differentiation of human associative frontal cortex (already at 7.5 postconceptional weeks, PCW). The most prominent regional patterning in the frontal lobe was seen during the subplate formation phase, as a unique feature of orbitobasal frontal cortex. Additionally, the laminar dynamics of DPN markers, along with the subventricular zone size and the mode of subplate formation, clearly indicate regional differentiation of cingulate cortex several months before arealization. Therefore, implementing a comparative (human/rhesus macaque) approach and advanced techniques (spatial transcriptomics, organoid model), we aim to answer a fundamental question concerning early regional differentiation of the human cerebral cortex.]]></summary_en></project><project>
<id>15021</id><title_hr><![CDATA[Kulturni krajolici metalurgije željeza u slivu rijeke Save i Drave tijekom antike i ranoga srednjega vijeka]]></title_hr><title_en><![CDATA[Cultural Landscapes of Iron Metallurgy in the Sava and Drava River Basin During Antiquity and the Early Middle Ages ]]></title_en><user_id>7810</user_id><user_firstLast_name>Tajana Sekelj Ivančan</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-1846</code><acronim><![CDATA[KulturFER]]></acronim><duration>29.12.2023 - 28.12.2027</duration><status>U tijeku</status><financ_value>101.267,50 eur</financ_value><scie_area_hr>Humanističke znanosti, Prirodne znanosti, Tehničke znanosti, </scie_area_hr><scie_area_en>Humanities, Natural sciences, Technological sciences, </scie_area_en><scie_field_hr>Arheologija, Geologija, Kemija, Metalurgija, </scie_field_hr><scie_field_en>Archeology, Geology, Chemistry, Metallurgy, </scie_field_en><institution_hr><![CDATA[Institut za arheologiju]]></institution_hr><institution_en><![CDATA[Institute of Archaeology in Zagreb]]></institution_en><team_members_id>11254, 25295, 2885, 20538, 12690, 865887, 12380, 866144, 866439, </team_members_id><team_members_names><![CDATA[Tatjana Tkalčec, Tena Karavidović, Sibila Borojević Šoštarić, Tomislav Brenko, Sanda Rončević, Adam Thiele, Ivan Valent, Slavica Filipović Filipović, Bela Torok, ]]></team_members_names><keywords_hr><![CDATA[kulturni krajolik, proizvodnja željeza, obrada željeza, antika, rani srednj vijek ]]></keywords_hr><keywords_en><![CDATA[cultural landscape, iron production, iron postreduction, Antiquity, Early Middle Ages ]]></keywords_en><summary_hr><![CDATA[Arheološki tragovi koji upućuju na proizvodnju i obradu željeza te distribuciju (polu)proizvoda na prostoru sliva rijeke Save i Drave prisutni su od razdoblja prapovijesti, no sustavna istraživanja metalurgije željeza su izostala. Geološki podaci o orudnjenjima ne pružaju mogućnost  studija provenijencije, eksploatacije i tehnološke iskoristivosti rudnih resursa u arheološkim razdobljima. Konkretni temelji za istraživanje postavljeni su kroz istraživanja dijela predložene istraživačke skupine a ogledaju se u: 1) razvoju interdisciplinarnog pristupa ubikaciji ležišta iskorištavanih u prošlosti i studija provenijencije, 2) značajnoj razini podataka o tehnologiji proizvodnje željeza koja čini bazu za komparativne studije, šireg vremenskog i prostornog konteksta. U ovom projektnom prijedlogu postavljena je hipoteza da su promjene i/ili kontinuitet vidljiv u tehnologiji proizvodnje i obrade željeza, organizaciji proizvodnih procesa i distribuciji (polu)proizvoda odraz sprege utjecaja prirodnih preduvjeta krajolika te šireg konteksta društvenih i ekonomskih prilika i mjena u razdoblju antike i ranoga srednjeg vijeka. U fokusu su: 1) karakteristike i geokemijski otisak panonskih i dinaridskih sirovina (željezne rude), 2) izvorišta sirovina te područja eksploatacije rudnih resursa, 3) komparativna analiza tehnologije proizvodnje i izlaznih (polu)proizvoda tijekom antike i ranoga srednjeg vijeka, 4) organizacija proizvodnih procesa i distribucija poluproizvoda tijekom promatranih razdoblja. Kako bi se definirala razina i vrsta utjecaja te način funkcioniranja ove proizvodne grane gospodarstva kroz duži vremenski period osmišljen je metodološki pristup koji po najvišim znanstvenim standardima, kroz interdisciplinarnu prizmu, pristupa istraživanju teme koja povezuje krajolik, tehnologiju i društvenu organizaciju, a čini ga suradnja četiri znanstvena polja: arheologije, geologije, kemije i metalurgije.]]></summary_hr><summary_en><![CDATA[Archaeological traces pointing to the production and processing of iron and the distribution of (semi)products in the area of the Sava and Drava river basins have been present since prehistoric times, but systematic research into iron metallurgy has not been carried out. Geological data on ore resources do not provide the possibility of studying the provenance, exploitation, and technological usability of mineral resources in archaeological periods. The concrete foundations for the research were laid through the research of a part of the proposed research group and are reflected in 1) the development of an interdisciplinary approach to ubication of deposits exploited in the past and provenance studies, 2) a significant level of data on the technology of iron production, which forms the basis for comparative studies, in a wider temporal and spatial context. It is hypothesized that the changes and/or continuity visible in the technology of iron production and processing, the organization of production processes and the distribution of (semi)products are a reflection of the influence of the natural preconditions of the landscape and social and economic circumstances through Antiquity and the Early Middle Ages. The focus is on 1) mineralogical and geochemical fingerprints of Pannonian and Dinaric raw materials (iron ore), 2) sources of raw materials and areas of exploitation of mineral resources, 3) comparative analysis of production technology and output (semi)products during Antiquity and the early Middle Ages, 4) organization of production processes and distribution of semi-finished products during the observed periods. In order to define the level and type of influence and the way this production branch of the economy functions over a longer period, a comprehensive methodological approach is devised, that approaches the research of the topic that connects landscape, technology, and social organization through an interdisciplinary prism.]]></summary_en></project><project>
<id>15025</id><title_hr><![CDATA[Globalna i lokalna dinamika na plohama]]></title_hr><title_en><![CDATA[Global and local dynamics on surfaces]]></title_en><user_id>1391</user_id><user_firstLast_name>Vesna Županović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-9820</code><acronim><![CDATA[GLODS]]></acronim><duration>15.12.2023 - 14.12.2027</duration><status>U tijeku</status><financ_value>199.037,02 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>2932, 2709, 2870, 3200, 2841, 29727, 20035, 26243, 856174, 865760, 869778, 17706, 872996, </team_members_id><team_members_names><![CDATA[Goran Radunović, Maja Resman, Sonja Štimac, Pavao Mardešić, Renato Huzak, Vlatko Crnković, Kristijan Kilassa Kvaternik, Dino Peran, Martin Klimeš, Jan Boronski, Luka Kraljević, Ana Anušić, Fran Mišković, ]]></team_members_names><keywords_hr><![CDATA[Henonovo i Lozijevo preslikavanje, granični ciklus, bifurkacija, kompleksna dimenzija, stohastički fraktal, sporo-brzi sustav, singularna perturbacija]]></keywords_hr><keywords_en><![CDATA[Henon map, Lozi map, Dulac problem, limit cycle, bifurcation, complex dimension,  stochastic fractal,  slow-fast system, singular perturbation]]></keywords_en><summary_hr><![CDATA[Dinamički sustavi su zanimljivi  teorijskoj i primijenjenoj matematici. Matematičko modeliranje prirodnih i društvenih pojava te predviđanje njihovog ponašanja daje vrijedan doprinos matematici, znanosti i inženjerstvu. Naši istraživački ciljevi povezani su s poznatim otvorenim problemima u dinamici. (1) Dinamika Hénonovih  i Lozijevih  preslikavanja.  Neobični  atraktor dobro je poznata pojava u kaotičnoj dinamici. Činjenica da Hénonovi atraktori modeliraju ponašanje difeomorfizama s homokliničkim tangentama, čini ih univerzalnom strukturom za proučavanje kaosa. Analiziramo topološku strukturu, dinamička svojstva i homokliničke točke neobičnih atraktora  Hénonovskih i Lozijevskih preslikavanja. (2) Singulariteti vektorskih polja i difeomorfizama i njihove bifurkacije.Slavni Hilbertov 16. problem ili Dulacov problem postavlja pitanje gornje ograde  broja graničnih ciklusa ravninskih polinomijalnih sustava. Problem  se svodi na traženje broja lokalnih fiksnih točaka Poincaréovog   preslikavanja oko invarijantnih skupova. Analiziramo  rješenje Dulacovog problema za koje je nedavno primijećeno da ima pogrešku. Pristup uključuje analizu epsilon-okoline orbite, metodu koja  dolazi iz fraktalne geometrije. (3) Povezivanje kompleksnih dimenzija sa stohastičkim fraktalima i  mjerama zakrivljenosti.Kompleksna dimenzija skupa, definirana kao skup polova  Lapidusove  zeta funkcije te povezana s poznatom Riemannovom zeta funkcijom, bit će generalizirana za stohastičke fraktale i povezana s nedavno razvijenom teorijom mjere fraktalne zakrivljenosti. (4) Fraktalna analiza familije orbita u ravninskim sporo-brzim sustavima. Singularne perturbacije bit će razmatrane korištenjem fraktalne geometrije i standardnih metoda kao što su blow-up i spori integrali divergencije.  Dimenzija i sadržaj Minkowskog mogu se koristiti za proučavanje graničnih ciklusa i bifurkacija u blizini patkastih periodičnih graničnih skupova ili kontaktnih točaka u 2-dimenzionalnim sporo-brzim sustavima.]]></summary_hr><summary_en><![CDATA[Analysis of dynamical systems has been recognized as an interesting subject in mathematics pure and applied. Mathematical modeling of  real world systems  and prediction of their behavior gives a valuable contribution to mathematics, science and engineering. Our research goals are related to some well-known long-standing open problems  in dynamics. (1) Dynamics of the Hénon and Lozi maps. The strange attractor is a well-known phenomenon in chaotic dynamics. The fact that the Hénon-like attractors model the behavior of diffeomorphisms with homoclinic tangencies, makes them a universal structure in the onset of chaos. We study topological structure, dynamical properties and homoclinic points of the  Hénon-like and Lozi-like strange attractors. (2)  Singularities of vector fields and diffeomorphisms and their bifurcations.The famous Hilbert 16th problem or the Dulac problem, which ask for an upper bound on the number of limit cycles in planar polynomial systems, are reduced to counting local fixed points of the first return maps around invariant sets. Here, the mistaken solution of the Dulac  problem will also be studied. New approach includes analysis of epsilon-neigborhood of an orbit using the idea  from fractal geometry.(3)  Relating complex dimensions to stochastic fractals and their curvature measures. The complex dimension of a set,  defined as the poles of the Lapidus (fractal) zeta function and related to the famous Riemann zeta function,  will be generalized to the stochastic setting and connected  to the theory of fractal curvature measures recently developed.(4) Fractal analysis of families of orbits in planar slow-fast systems.Singular perturbations  will be considered using standard methods such as blowing-ups, slow divergence integrals, and also  fractal geometry.  Minkowski dimension and content, fractal strings, etc. can be used to study limit cycles and bifurcations near canard limit periodic sets or contact points in 2-dimensional slow-fast systems.]]></summary_en></project><project>
<id>15030</id><title_hr><![CDATA[Kulinarske prakse, gospodarstvo i strategije korištenja zemljišta tijekom bakrenog doba u istočnoj Slavoniji]]></title_hr><title_en><![CDATA[Culinary practices, husbandry and land-use strategies during the Copper Age in Eastern Croatia]]></title_en><user_id>7519</user_id><user_firstLast_name>Ina Miloglav</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-9489</code><acronim><![CDATA[CULPLUS]]></acronim><duration>18.12.2023 - 17.12.2027</duration><status>U tijeku</status><financ_value>106.669,44 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Arheologija, </scie_field_hr><scie_field_en>Archeology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>19197, 865671, 865566, 26710, 2920, 865535, 865596, 19244, 865746, 29684, </team_members_id><team_members_names><![CDATA[Jacqueline Balen, Jasna Vuković, Jelena Bulatović, Sara Essert, Marta Mileusnić, Juan Jose Garcia-Granero, Dushanka Urem, Miroslav Vuković, Cristina Barrocas Dias, Mia Marijan, ]]></team_members_names><keywords_hr><![CDATA[arheologija, bakreno doba, arheometrija, keramika, iskorištavanje zemljišta]]></keywords_hr><keywords_en><![CDATA[archaeology, Copper Age, archaeometry, pottery, land-use]]></keywords_en><summary_hr><![CDATA[Cilj predloženog projekta je identificirati promjene u prehrambenim praksama u bakrenom dobu u istočnoj Slavoniji promatrane regionalno i dijakronijski, utvrditi eventualne uzroke promjena u prehrambenim aktivnostima i strategijama iskorištavanja biljaka i životinja te utvrditi na koji način se prilagodbe u prehrambenoj ekonomiji mogu povezati s društvenim i tehnološkim transformacijama. Kao predmet interesa odabran je geografski prostor između Vinkovaca-Đakova-Slavonskog Broda koji naseljavanjem obuhvaća razdoblje od srednjeg do kasnog bakrenog doba. Analize prehrambenih navika i kulinarskih praksi povezane su sa širim pitanjima upravljanja okolišem i strategijama korištenja zemljišta koje uključuju interdisciplinaran, sustavan i sistematičan metodološki pristup. Okosnicu istraživanja čini integrirani pristup projektnoj temi u kojem je svaki metodološki korak povezan horizontalno i vertikalno, a uključivat će funkcionalnu analizu lončarije (primarna klasifikacija, proučavanje tragova upotrebe, analize organskih ostataka i tehnološke analize), arheobotaničke (makro i mikrobotaničke) i palinološke analize, arheozoološke te radiokarbonske i analize stabilnih izotopa. Istraživački tim sastavljen od stručnjaka iz različitih znanstvenih disciplina (arheologija, geologija, kemija, biologija) svojim kompetencijama i iskustvom doprinijet će ostvarenju projektnih ciljeva, razvijajući nove teorije, spoznaje i modele društvene dinamike na promatranom području te uspostaviti znanstvene protokole za prikupljanje, pohranu i obradu podataka. S obzirom da je bakreno doba najslabije istražen prapovijesni period na području Hrvatske, te da raspolažemo s vrlo skromnim i oskudnim podacima, projektni rezultati koji uključuju integrirani metodološki pristup koji do sada nije primijenjen u Hrvatskoj popunit će praznine novim spoznajama o gospodarstvu, prehrambenim praksama, iskorištavanju zemljišta i prilagođavanju na okoliš tadašnjeg stanovništva.]]></summary_hr><summary_en><![CDATA[The proposed project aims to identify changes in dietary practices in the Copper Age in Eastern Slavonia, regionally and diachronically. It also aims to identify possible causes of changes in culinary activities and strategies for plant and animal exploitation and explore how adaptations in the food economy can be linked to social and technological transformations. The geographical area between Vinkovci, Đakovo, and Slavonski Brod was chosen as the research area, covering the period from the middle to late Copper Age. Analyses of dietary habits and culinary practices relates to wider issues of environmental management and land use strategies. necessitating an interdisciplinary, systematic, and methodological approach to research. The core of the research proposal is formed around an integrated approach to a project theme where each methodological step is linked horizontally and vertically and will include: functional analysis of pottery (primary classification, use-alteration analysis, organic residue analysis, and technological analysis); archaeobotanical (macro and microbotanical) and palynological analyses; archaeozoological, and stable isotope and the radiocarbon analyses. A research team composed of experts from different scientific disciplines (archaeology, geology, chemistry, biology) with its competencies and experience will contribute to the achievement of project objectives, developing new theories, insights, and models of social dynamics in the project area, and establish scientific protocols for data collection, storage, and processing. Given that the Copper Age has been the least researched prehistoric period in Croatia, and because we have very modest and scarce data, project results, including an integrated methodological approach that has not been applied so far in Croatia, will fill the gaps with new knowledge about the economy, food practices, land use and environmental adaptation of the population at that time.]]></summary_en></project><project>
<id>15036</id><title_hr><![CDATA[Vjerodostojne analitike učenja i umjetna inteligencija za smislen dizajn učenja ]]></title_hr><title_en><![CDATA[Trustworthy learning analytics and artificial intelligence for sound learning design ]]></title_en><user_id>12508</user_id><user_firstLast_name>Blazenka Divjak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-2854</code><acronim><![CDATA[TRUELA]]></acronim><duration>30.12.2023 - 29.12.2027</duration><status>U tijeku</status><financ_value>119.344,35 eur</financ_value><scie_area_hr>Društvene znanosti, Interdiciplinarne znanosti, Prirodne znanosti, Tehničke znanosti, </scie_area_hr><scie_area_en>Social sciences, Interdisciplinary scientific area, Natural sciences, Technological sciences, </scie_area_en><scie_field_hr>Informacijske znanosti, Matematika, Računarstvo, Obrazovne znanosti, Interdisciplinarne prirodne znanosti, Interdisciplinarne tehničke znanosti, Interdisciplinarne društvene znanosti, </scie_field_hr><scie_field_en>Information sciences, Mathematics, Computer sciences, Educational sciences, Interdisciplinary natural sciences, Interdisciplinary technological sciences, Interdisciplinary social sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet organizacije i informatike]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Organization and Informatics]]></institution_en><team_members_id>12531, 12590, 866161, 5442, 13136, 27043, 866366, 29420, 858423, 26859, 858420, 858424, 866068, 866146, 866135, 27045, 25380, </team_members_id><team_members_names><![CDATA[Vjeran Strahonja, Valentina Kirinić, Zlatko Erjavec, Petra Žugec, Goran Hajdin, Damir Horvat, Barbi Svetec, Bart Rienties, Lourdes Guardia, Van Petegem Wim, Yi-Shan Tsai, Dragan Gasevic, Hanni Muukkonen, Alexander Tillmann Tillmann, Mladen Raković, Petra Vondra, Renato Babojelić, ]]></team_members_names><keywords_hr><![CDATA[analitike učenja, umjetna inteligencija, dizajn učenja, LMS, vjerodostojnost, e-vrednovanje, putovi učenja, LA i AI algoritmi]]></keywords_hr><keywords_en><![CDATA[learning analytics, artificial intelligence, learning design,  learning management systems, trustworthiness, e-assessment, learning patterns, LA and A]]></keywords_en><summary_hr><![CDATA[Širi je cilj projekta razviti nove pristupe i metode analitika učenja (LA) i umjetne inteligencije (AI) koje koriste velike količine podataka generiranih prvenstveno u sustavima za upravljanje učenjem (LMS). Ove metode i pristupi će omogućiti: (1) razvoj okvira za vjerodostojne analitike učenja i algorit(a)ma umjetne inteligencije koji će se koristiti za podršku usporedbi planiranog dizajna učenja i dizajna učenja postojećih kolegija u sustavu za upravljanje učenjem te dati preporuke za unapređenja u skladu s dizajnom učenja, i (2) identificirati i analizirati obrasce učenja u online i mješovitim okruženjima za učenje, te tako unaprijediti razumijevanje procesa učenja. Metodologija istraživanja planirana je oko pet znanstvenih ciljeva projekta, odražavajući probleme vezane uz: (1) pouzdanost LA i AI, smislen dizajn učenja temeljen na LA; (2) prepoznavanje putova učenja i njihovo povezivanje s LD; (3) razlike između obrazaca učenja uspješnijih i manje uspješnih studenata na temelju njihova digitalnog otiska, kao temelja za smislene preporuke; (4) osiguravanje valjanog, vjerodostojnog i pouzdanog e-vrednovanja; (5) spremnost nastavnika visokog obrazovanja da usvoje nove tehnologije i inoviraju učenje i poučavanje.Projektom će se ponuditi rješenja navedenih problema kroz relevantne metodologije, metode, algoritme i okvire, kao i praktične materijale i materijale za usavršavanje te preporuke. Projekt uključuje blisku međunarodnu suradnju istraživačkog tima (9) s Fakulteta organizacije i informatike Sveučilišta u Zagrebu sa međunarodno priznatih i vodećih stručnjaka (8) iz područja LA, AI, LD i obrazovnih znanosti. Budući da su analitike učenja interdisciplinarno znastveno područje, projekt će iskoristiti stručnost te pridonijeti istraživanju u područjima obrazovanja, znanosti o podacima, informacijske i komunikacijske znanosti, primijenjene matematike za razvoj algoritama, ali i donošenja odluka.]]></summary_hr><summary_en><![CDATA[The wider objective of the project is to develop new learning analytics (LA) and artificial intelligence (AI) approaches and methods that use large amounts of data generated primarily in learning management systems (LMS). These methods and approaches will: (1) generate LA that inform learning design (LD)  and support the implementation of innovative teaching methods and e-assessment strategies to help students overcome challenges related to reduced social interactions in online learning environments and achieve the intended learning outcomes, and (2) detect and analyze learning patterns in online and blended learning environments, and thus advance understanding of learning processes. The research methodology has been planned around five scientific objectives of the project, reflecting problems related to: (1) trustworthiness of LA and AI, meaningful learning design based on LA; (2) recognizing learning paths and linking them to LD; (3) differences between learning patterns of more and less successful students based on their digital footprint, as the basis for meaningful recommendations for students; (4) ensuring valid, reliable and trustworthy e-assessment; (5) readiness of HE teachers to adopt new technologies and innovate T&L. To address these problems, the project will produce relevant methodologies, methods, algorithms and frameworks, as well as practical and training material and recommendations. The project includes close international cooperation of the research team (9) based at the Faculty of Organization and Informatics of the University of Zagreb with  internationally recognised and leading experts (8) in the fields of LA, AI, LD, and educational science in general. As LA is an interdisciplinary field, the project will exploit expertise and contribute to research in the areas of education science, data science, information and communication science, applied mathematics for algorithm development, and decision-making.]]></summary_en></project><project>
<id>15038</id><title_hr><![CDATA[Teorijska istraživanja na razmeđu filozofije psihologije i društvenih praksi ]]></title_hr><title_en><![CDATA[Theoretical investigations at the intersection of philosophy of psychology and social practices]]></title_en><user_id>4172</user_id><user_firstLast_name>Marko Jurjako</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-1788</code><acronim><![CDATA[TIPPS]]></acronim><duration>29.12.2023 - 28.12.2027</duration><status>U tijeku</status><financ_value>100.380,78 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filozofija, Interdisciplinarne humanističke znanosti, </scie_field_hr><scie_field_en>Philosophy, Interdisciplinary humanities, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Filozofski fakultet u Rijeci]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>865691, 865695, 865224, 3788, 869265, </team_members_id><team_members_names><![CDATA[Katrina Sifferd Sifferd, Sam Wilkinson Wilkinson, Mladen Bošnjak, Zdenka Brzović, Miguel NunezdePrado Gordillo, ]]></team_members_names><keywords_hr><![CDATA[Problem sučeljavanja/integracije, eksplikacija, mentalni poremećaj, krivična odgovornost, osobna i podosobna objašnjenja]]></keywords_hr><keywords_en><![CDATA[The interface/integration problem, explication, mental disorder, criminal responsibility, personal and subpersonal explanations]]></keywords_en><summary_hr><![CDATA[Cilj projekta je istražiti teorijske temelje psihologije i kognitivne znanosti te njihove implikacije za važne društvene prakse. Polazna točka naših istraživanja je činjenica da je kognitivna neuroznanost uvelike povećala razumijevanje neurobioloških temelja psiholoških sposobnosti koje su značajne za nekoliko osjetljivih društvenih praksi. Međutim, njihova sve veća primjena u praktičnim kontekstima postavlja nekoliko gorućih izazova u kaznenom pravu, medicinskoj etici i bioetičkim istraživanjima. Na primjer, evidencija koja dolazi iz istraživanja koja koriste magnetske rezonance mozga koriste se za procjenu odgovornosti pojedinaca u kliničkim i pravnim kontekstima, kao i za promišljanje pojma mentalne uračunljivosti na kojem se temelje psihijatrijske i pravne prakse. Međutim, da bismo procijenili relevantnost neuroznanstvenih dokaza u takvim kontekstima, moramo ih moći prevesti u zdravorazumske psihološke termine koji se nalaze u podlozi društvenih praksi. Značajni nedostatak u literaturi je da se taj problem prijevoda neovisno pojavljuje u raspravama u filozofiji prava i filozofiji psihijatrije, gdje se uvelike koriste pojmovi autonomne osobe, odgovornosti i mentalnog poremećaja, a da se o njemu ne raspravlja na sustavan način unutar uspostavljenog analitičkog okvira. Kako bi se premostio ovaj nedostatak u literaturi, projektom TIPPS predlažemo da se problem prevođenja utemelji na teorijskom okviru koji je razvijen u sklopu rasprave o problemu sučeljavanja iz teorijske psihologije. Problem sučeljavanja odnosi se na opći izazov integracije zdravorazumskih psiholoških objašnjenja koja karakteriziraju osobnu razinu s (neuro)znanstvenim objašnjenjima koja karakteriziraju različite podosobne razine ljudskog funkcioniranja. Na ovoj teorijskoj pozadini, cilj projekta TIPPS je razjasniti glavne kandidate za rješenje problema sučeljavanja i kako njihova regimentacija može omogućiti napredak pri rješavanju problema prevođenja u filozofiji prava i filozofiji psihijatrije.]]></summary_hr><summary_en><![CDATA[This project aims to investigate the theoretical foundations of psychology and cognitive science, and their implications for important social practices. The starting point of our investigations is the fact that cognitive neuroscience has greatly increased our understanding of the neurobiological underpinnings of psychological abilities that are significant for several sensitive social practices. However, their increasing application in practical contexts raises several pressing challenges in criminal law, medical ethics, and bioethical research more generally. For example, neuroimaging evidence is being used to assess responsibility of individuals in clinical and legal settings, as well as for rethinking the notion of mental sanity on which the psychiatric and legal practices are based. However, to assess the relevance of the neuroscientific evidence in such contexts, we need to be able to translate it in commonsense psychological terms that underpin our social practices. A significant gap in the literature is that the translation problem comes up independently in discussions of law and psychiatry where the notions of the autonomous person, responsibility, and mental disorder intersect, without being discussed in a systematic way within an established analytic framework. To bridge this gap, this project proposes to ground the translation problem in the framework that has been developed in the discussions of the interface problem from theoretical psychology. The interface problem refers to a general challenge of integrating the commonsense psychological explanations characterizing the personal level with (neuro)scientific explanations characterizing the subpersonal levels of functioning. Based on this background, the project aims to clarify the main contenders for the solution of the interface problem and how their regimentation can make advancements on the translation problems as they appear in philosophy of law and philosophy of psychiatry.]]></summary_en></project><project>
<id>15041</id><title_hr><![CDATA[Pouzdanost i nesigurnosti brodskog sustava potpori odlučivanju za sigurnu i &#39;&#39;zeleniju&#39;&#39; plovidbu]]></title_hr><title_en><![CDATA[REliaBility and Uncertainty of Ship decision support system for safe and green navigation]]></title_en><user_id>4256</user_id><user_firstLast_name>Jasna Prpić-Oršić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-2821</code><acronim><![CDATA[REBUS]]></acronim><duration>31.12.2023 - 30.12.2027</duration><status>U tijeku</status><financ_value>199.084,21 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Brodogradnja, Računarstvo, Strojarstvo, Tehnologija prometa i transport, </scie_field_hr><scie_field_en>Naval architecture, Computer sciences, Mechnical engineering, Transport technology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Tehnički fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Engineering]]></institution_en><team_members_id>810, 24206, 24204, 865634, 858448, 24213, 5830, 4179, 4890, 3868, 19041, 2951, 865613, 865636, 872939, </team_members_id><team_members_names><![CDATA[Joško Parunov, Vedran Mrzljak, Kenji Sasa, Josip Orović, Ivan Sulovsky, Luca Braidotti, David Brčić, Duško Pavletić, Odd Magnus Faltinsen, Tomislav Mrakovčić, Natalija Vitali, Marko Valčić, ANTON TURK Turk, Marijana Balas, Ivana Čabrijan, ]]></team_members_names><keywords_hr><![CDATA[brod, pomorstvenost, sustav potpori odlučivanju, emisija stakleničkih plinova, navigacija, sigurnost]]></keywords_hr><keywords_en><![CDATA[ship, seakeeping, decision support system, greenhause gases emissions, navigation, safety]]></keywords_en><summary_hr><![CDATA[Cilj istraživanja u okviru projekta Pouzdanost i nesigurnosti brodskog sustava potpori odlučivanju za sigurnu i &#39;&#39;zeleniju&#39;&#39; plovidbu (REBUS) je analiza pouzdanosti i nesigurnosti vezanih uz  sustav potpore odlučivanju (Decision Support System - DSS) kapetanima broda, kao i zapovjednicima stroja, a koji bi doprinio ”zelenijoj” i sigurnijoj plovidbi brodova. Projekt se nastavlja na tekući projekt Hrvatske zaklade za znanost, br. IP-2018-01-3739 Sustav potpore odlučivanju za zeleniju i sigurniju plovidbu brodova  (DESSERT) tijekom kojeg se razvija sustav potpore odlučivanja koji, osim ekonomskih (potrošnja), uzima u obzir ekološke aspekte i aspekte sigurnosti tijekom navigacije. Istraživanja vezana uz analizu DSS-a odvijat će se u dva osnovna smjera: analiza nesigurnosti i procjena pouzdanosti sustava potpore odlučivanju za energetski učinkovitija plovidbu uz smanjenje emisije stakleničkih plinova; analiza nesigurnosti i procjena pouzdanosti sustava za pravovremenu reakciju u slučaju naplavljivanja broda.Mjerenja navigacijskih i pogonskih parametara broda koristeći više različitih mjernih sustava analizirat će se sa stanovišta definiranja nesigurnosti i procjene pouzdanosti  samih mjerenja. Velika baza mjerenih podataka, kao i numerički dobivenih podataka korištenjem računarske dinamike fruida (CFD)  te podataka dobivenih na simulatoru navigacije koristit će se za analizu pouzdanosti numeričkog modela za procjenu smjerovnog spektra valova iz mjerenih njihanja broda, kao i za validaciju metodologije procjene brzine broda, potrošnje goriva i emisije stakleničkih plinova. Cilj je sustavno analizirati sustav potpore odlučivanju na brodu uzimajući u obzir projektantsku, strojarsku i pomorsku ekspertizu u cilju stvaranja sigurnog i ekološki učinkovitog ili &#39;&#39;zelenijeg&#39;&#39; broda i plovidbe. Projektni tim sastoji se od znanstvenika koji su stručnjaci u brodogradnji, strojarstvu,  pomorskom inženjerstvu i računarstvu koji omogućuju multidisciplinarno rješavanje ovog problema.]]></summary_hr><summary_en><![CDATA[The goal of the research in a frame of project REliaBility and Uncertainty of Ship decision support system for safe and greener navigation – REBUS is the analysis of reliability and uncertainties ralarted to Decision Support System (DSS) is planned for ship captains as well as machine commanders, which would contribute to &#39;&#39;greener&#39;&#39; and safer navigation of ships.The project continues the ongoing Croatian Science Foundation project, No. IP-2018-01-3739 DEcision Support System for green and safe ship RouTing (DESSERT), which is developing a decision support system that takes into account not only economic but also environmental and safety aspects of navigation. Research related to DSS analysis will proceed in two basic directions: Uncertainty analysis and reliability assessment of the decision support system for more energy efficient navigation while reducing greenhouse gas emissions; Uncertainty analysis and reliability assessment of the system for timely response in case of a flooding.Measurements of navigation and operational parameters of the ship using various measurement systems will be analyzed from the point of view of defining uncertainty and evaluating the reliability of the measurements themselves. A large database of measured data, data obtained by CFD and on navigation simulator will be used to analyze the reliability of a numerical model for estimating the directional spectrum of waves from measured ship motions and to validate the methodology for estimating ship speed, fuel consumption and GHG emissions.The goal is to systematically analyze the shipboard decision support system, taking into account design, engineering, and maritime expertise, to create a safer and more environmentally efficient or &#39;&#39;greener&#39;&#39; ship and navigation. The project team consists of scientists who are experts in naval architecture, mechanical engineering, marine engineering and computer science, which enables a multidisciplinary solution to this problem.]]></summary_en></project><project>
<id>15043</id><title_hr><![CDATA[Modifikacija strukture i vezne površine biomaterijala i tvrdih zubnih tkiva]]></title_hr><title_en><![CDATA[Structure and bonding surface modification of biomaterials and hard dental tissues ]]></title_en><user_id>12362</user_id><user_firstLast_name>Ivana Miletić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-6065</code><acronim><![CDATA[MODIBIODENT]]></acronim><duration>18.12.2023 - 17.12.2027</duration><status>U tijeku</status><financ_value>199.084,21 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Dentalna medicina, Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Dental medicine, Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Stomatološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Dentistry]]></institution_en><team_members_id>23313, 23315, 23323, 23316, 866150, 858408, 13213, 866156, 7026, 29515, 866195, 866242, 23365, 873075, </team_members_id><team_members_names><![CDATA[Jukić Krmek, Anja Baraba, Jurica Matijević, Ana Ivanišević, Anja Ivica, Ivan Šalinović, Ivan Zajc, Mato Sušić, Zdravko Schauperl, Ana Pilipović, Salvatore Sauro, Matthias Zehnder, Maja Bilić Prcić, Maria Bota, ]]></team_members_names><keywords_hr><![CDATA[biointeraktivni materijali, bioaktivni materijali, restaurativna dentalna medicina, endodoncija, laser]]></keywords_hr><keywords_en><![CDATA[biointeractive materials, biaoctive materials, restorative dental medicine, endodontics, laser ]]></keywords_en><summary_hr><![CDATA[Zubni karijes još uvijek predstavlja globalni problem s prevalencijom u odrasloj populaciji od čak 90%. Uslijed karijesa, dolazi do oštećenja tvrdih zubnih tkiva, cakline i dentina, a nastavkom bolesti i do odumiranja zubne pulpe te potrebe za endodontskim liječenjem. Moderni pristup u terapiji bolesti sve se više temelji na uporabi materijala kojima se nastoji obnoviti oštećena struktura zuba ili potaknuti tkivni odgovor na cijeljenje. Idealni materijal koji bi u potpunosti udovoljio svim zahtjevima još uvijek nije pronađen budući da se pokušava naći balans između optimalnih mehaničkih svojstva te preventivnog i terapijskog djelovanja materijala, a uzimajući u obzir složeno i promjenjivo oralno mikro okruženje. Stoga, cilj ovog projekta je ispitati nove eksperimentalne i komercijalno dostupne biomaterijale u  interakciji s tvrdim zubnim tkivima te utjecaj modifikacije vezne površine tvrdih zubnih tkiva djelovanjem lasera i zračne abrazije na njihovo ponašanje pri dinamičkim uvjetima. Istraživanja će obuhvatiti  dvije skupine materijala: biointeraktivne restuarativne materijale i njihove modifikacije s analozima nekolagenih proteina (NCP) te bioaktivne kalcij-silikatne cemente i njihove modifikacije  NCP i polimerima. Istraživanja ovog projektnog prijedloga pridonijela bi boljem razumijevanju bioloških, kemijskih i mehaničkih svojstava ispitivanih materijala i njihove interakcije  s tvrdim zubnim tkivima kako bi se dale jasne smjernice za odabir najprikladnijih materijala i postupaka za određene kliničke situacije.]]></summary_hr><summary_en><![CDATA[Dental caries still represents a global problem with a prevalence in the adult population of as much as 90%. Caries results in damaged hard dental tissues, enamel and dentin, and with the progression of the disease, dental pulp is affected and endodontic treatment is needed. The modern approach in caries treatment is based on either using the materials for restoration of lost hard dental tissues or stimulating tissue healing. An ideal material that would fully meet all requirements has not yet been found, since the goal is to achieve balance between optimal mechanical properties and the preventive and therapeutic effect of the material, while taking into account the complex and variable oral microenvironment. Therefore, the main objective of this project is to investigate new experimental and commercially available biomaterials in interaction with hard dental tissues and the influence of modification of the bonding surface of hard dental tissues by laser and air abrasion on the behavior of the materials under dynamic conditions. Research will cover two groups of materials: biointeractive restorative materials and their modifications with analogs of non-collagen proteins (NCP) and bioactive calcium-silicate cements and their modifications with NCP and polymers. The research proposed by this project would contribute to a better understanding of the biological, chemical and mechanical properties of the investigated materials and their interaction with hard dental tissues in order to provide clear guidelines for the selection of the most suitable materials and procedures for certain clinical situations.]]></summary_en></project><project>
<id>15044</id><title_hr><![CDATA[Afine verteks-algebre i W-algebre]]></title_hr><title_en><![CDATA[Affine vertex algebras and W-algebras]]></title_en><user_id>92</user_id><user_firstLast_name>Dražen Adamović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-9006</code><acronim><![CDATA[AVAWA]]></acronim><duration>31.12.2023 - 30.12.2027</duration><status>U tijeku</status><financ_value>128.208,44 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>632, 865593, 17775, 865650, 1252, 638, 865891, 631, 866024, </team_members_id><team_members_names><![CDATA[Ozren Perše, Ivana Vukorepa, Ana Kontrec, Veronika Pedić Tomić, Tomislav Šikić, Mirko Primc, Paolo Papi, Gordan Radobolja, Pierluigi Moseneder Frajria, ]]></team_members_names><keywords_hr><![CDATA[verteks-algebra, afina Liejeva superalgebre, W-algebra, Whittakerovi moduli, pravila fuzije]]></keywords_hr><keywords_en><![CDATA[vertex algebra, affine Lie algebras, W-algebras, Whittaker modules, fusion rules]]></keywords_en><summary_hr><![CDATA[U predloženom istraživanju proučavat ćemo verteks-algebre koje se prirodno javljaju u matematičkim i fizikalnim teorijama, te nastaviti prethodna istraživanja našeg tima. Proučavat ćemo    logaritamske verteks-algebre koje su povezane s fizikom,  tenzorskim kategorijama i kvantnim grupama. Na taj način bi nastavli prethodna istraživanja započeta u člancima  D. Adamovića, A. Milasa o triplet algebri, te nova istraživanja D. Adamović, T. Creutzig, N. Genra,  J. Yang, Comm. Math. Phys (2021) koja povezuju te algebre s 4d konformnom teorijom polja. Nastavit ćemo istraživanje konformnih ulaganja verteks-algebri  iz zajedničkih članaka D. Adamovića i  O. Peršea s V. Kacom,  P. Papijem, i P. Moseneder Frajrijom objavljenim u  Selecta Mathematica NS (2018),   Int. Math. Res. Not. (2020), Advances  Math. (2020, 2022).  Generalizirat ćemo rezultate iz  D. Adamović,  G. Radobolja  Commun. Contemp. Math. (2019) na širu klasu verteks-algebri. Proučavat ćemo afine verteks-algebre i W-algebre, te analizirati teoriju reprezentacija tih algebri na kolapsirajućim nivoima. Metode iz članka D. Adamović, O. Perše, I. Vukoprepa, Comm. Contemp. Math. (2021) ćemo primjeniti na širu klasu afinih verteks-algebri na nivoima koju nisu dopustivi.  Važan dio istraživanja bit će posvećen određivanju fuzijskih algebri za kategorije težinskih modula afinih verteks i W-algebri koristeći metode iz članaka D. Adamovića, V. Pedić, Journal of Math. Phys. (2019) i D. Adamović, A. Kontrec, Transformation Groups (2022). U tom istraživanju primjenit ćemo i nove realizacije afinih verteks-algebri dobivenih preko inverzne redukcije, te pomoću njih konstuirati  logaritamske module i operatore ispreplitanja. Također planiramo primijeniti verteks-algebarske metode na Whittakerove module afinih Liejevih algebri i W-algebri. M. Primc i T. Šikić će istraživati kombinatorne baze i kombinatorne identitete povezane s afinim verteks-algebrama.]]></summary_hr><summary_en><![CDATA[We study logarithmic vertex algebras with origin in physics, connected also with tensor categories and quantum groups.In this way, we continue the previous research started in the articles by D. Adamović, A. Milas on the triplet algebra, and the new research by D. Adamović, T. Creutzig, N. Genra, J. Yang, Comm. Math. Phys (2021) which connects these algebras with 4d conformal field theory. We will continue the research of conformal embeddings  of vertex algebras in joint articles  of  D. Adamović and O. Perše with V. Kac, P. Papi, and P. Moseneder Frajrija published in  Selecta Mathematica NS (2018), Int. Math. Res. Not.(2020), Advances in Math. (2020, 2022). We will study affine vertex-algebras and W-algebras, and analyse the representation theory of these algebras on collapsing levels. We will  study the generalization of results from   D. Adamovića,  G. Radobolje Commun. Contemp. Math. (2019) to the higher rank case. Methods from the article D. Adamović, O. Perše, I. Vukorepa, Commun. Contemp. Math. (2021) will be applied to a wider class of affine vertex-algebras at levels that are not admissible.   An important part of the research will be devoted to the determination of fusion algebras for the categories of weight modules of affine vertices and W-algebras using methods from the articles of D. Adamović, V. Pedić, Journal of Math. Phys. (2019) and D. Adamović, A. Kontrec, Transformation Groups (2022). In this research, we will also apply new realizations of affine vertex-algebras obtained through inverse reduction, and construct logarithmic modules and intertwining operators. We also plan to apply vertex algebraic methods in studying Whittaker modules for affine Lie algebras and W-algebras. T. Šikić and M. Primc will investigate combinatorial bases and combinatorial identities related to affine vertex algebras.]]></summary_en></project><project>
<id>15047</id><title_hr><![CDATA[Pluralitet aktera u Dubrovačkoj Republici: politika i društvo, institucije i praksa ]]></title_hr><title_en><![CDATA[Plurality of actors in the Republic of Dubrovnik: politics and society, institutions and practice]]></title_en><user_id>739</user_id><user_firstLast_name>Zdenka Janeković Roemer</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-4560</code><acronim><![CDATA[PLURACTA]]></acronim><duration>15.12.2023 - 14.12.2027</duration><status>U tijeku</status><financ_value>76.574,40 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Povijest, Povijest umjetnosti, Interdisciplinarne humanističke znanosti, </scie_field_hr><scie_field_en>History, Art history, Interdisciplinary humanities, </scie_field_en><institution_hr><![CDATA[Hrvatska akademija znanosti i umjetnosti]]></institution_hr><institution_en><![CDATA[Croatian Academy of Sciences and Arts]]></institution_en><team_members_id>386, 481, 398, 726, 7658, 5998, 389, 1097, 1091, 23278, </team_members_id><team_members_names><![CDATA[Nella Lonza, Vesna Miović, Relja Seferović, Lovro Kunčević, Stjepan Ćosić, Danko Zelić, Rina Kralj-Brassard, Kristina Puljizević, Antun Koncul, Vedran Stojanović, ]]></team_members_names><keywords_hr><![CDATA[Hrvatska povijest, Dubrovačka Republika, povijesni akteri, srednji vijek, rani novi vijek]]></keywords_hr><keywords_en><![CDATA[Croatian history, The Republic of Dubrovnik, historical actors, Middle Ages, Early Modern Period]]></keywords_en><summary_hr><![CDATA[Projekt ima za cilj preispitati tradicionalnu interpretaciju aktera dubrovačke povijesti koja se oslanja na pravne kategorije i ideologiju Republike te rekonstruirati realno stanje obilježeno pluralitetom i heterogenošću aktera. Projekt će istražiti interakcije između institucija, skupina i pojedinaca, kao i različitih oblika lokalne i regionalne vlasti, koji su obilježavali dubrovačku povijest od 14. stoljeća do pada Republike. Projekt će ukazati na multifokalnost, mnoštvo društvenih aktera, pojedinaca, skupina i praksi na institucionalnom i izvaninstitucionalnom planu. Cilj tog pristupa je otkriti slabije primjetne društvene obrasce, zakrivene aristokratskim, institucionalnim, normativnim i staleškim okvirom koji pruža previše statičnu i shematsku sliku. Nova istraživačka perspektiva revidirat će spoznaje o djelovanju elita na društvo, kao i političke, ideološke i pravne temelje zajednice. Istražit će se i utjecaj drugih društvenih aktera na normativni, politički sustav. Istražit će se uloga Crkve i kršćanstva u izgradnji mehanizama identifikacije s gradom i društvenog konsenzusa. Projekt će uključiti i pojedince na rubu društva kroz istraživanje karitativnih praksi i ustanova te zdravstvene politike komune. Istražit će se i prostorni okvir urbanog života te povezati umjetnički i zanatski rad s drugim aspektima društvenih odnosa. Na nov će se način promišljati dubrovačka diplomacija, uzimajući u obzir pluralitet i heterogenost aktera u komunikaciji sa sredozemnim i europskim svijetom. Istražit će se procesi koji su doveli do sloma Republike i njezine stare političke i društvene matrice. Konačan rezultat bit će rekonstrukcija pluraliteta aktera dubrovačke povijesti te prevladavanje pojednostavljenih i shematskih podjela koje još uvijek obilježavaju historiografski diskurs.]]></summary_hr><summary_en><![CDATA[The project aims to re-examine the traditional interpretation of the actors of Dubrovnik&#39;s history, which relies on legal categories and ideology of the Republic, and to reconstruct real situation characterized by the plurality and heterogeneity of actors. The project will explore interactions between institutions, groups and individuals, as well as different forms of local and regional authorities, which marked Dubrovnik&#39;s history from the 14th century until the fall of the Republic. The project will point to multifocality, plurality of social actors, individuals, groups and practices, on institutional and non-institutional level. It aims to discover less noticeable social patterns, hidden behind the institutional and normative framework. New research perspective will reconsider the influence of elites, as well as political, ideological and legal foundations of the community. The influence of other social actors on the political and normative system will also be investigated. The project will address the role of Christianity and Church in creation of mechanisms od identification with the city and the achieving of social consensus. It will include the individuals on the margins of society through the research of charitable practices, institutions and the public health policy. The research will encompass the spatial framework of urban life and relate artistic and craft work with other aspects of social relations. The project will offer a new way of conceptualizing Dubrovnik’s diplomacy, considering the plurality of actors in communication with Mediterranean and European world. It will address processes that led to political breakdown of Dubrovnik Republic and its centuries old political and social matrix. The final result will be an insight into the plurality of actors of Dubrovnik’s history, and overcoming the simplistic and schematic which still influence the historiographic discourse.]]></summary_en></project><project>
<id>15055</id><title_hr><![CDATA[Sekundarna nukleacija i rast nanočestica uz pomoć plazmona]]></title_hr><title_en><![CDATA[Plasmon-Assisted Secondary Nucleation and Growth of Nanoparticles]]></title_en><user_id>21151</user_id><user_firstLast_name>Stefano (Antonio) Mezzasalma</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-3456</code><acronim><![CDATA[POTENTIALS]]></acronim><duration>31.12.2023 - 30.12.2027</duration><status>U tijeku</status><financ_value>194.253,10 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, Kemija, Interdisciplinarne prirodne znanosti, </scie_field_hr><scie_field_en>Physics, Chemistry, Interdisciplinary natural sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>865703, 865493, 2656, 25286, 869947, 872895, 812, </team_members_id><team_members_names><![CDATA[Marek Grzelczak, Roberto Morandotti, Boris Okorn, Matej Bubaš, Ivan Petranovic, Ismail Ibrahim, Jordi Sancho-Parramon, ]]></team_members_names><keywords_hr><![CDATA[nanoznanost, nukleacija i rast, meka materija, statistička fizika i termodinamika, optika i plazmonika, THz znanost]]></keywords_hr><keywords_en><![CDATA[nanoscience, nucleation and growth, soft matter, statistical physics and thermodynamics, optics and plasmonics, THz science]]></keywords_en><summary_hr><![CDATA[POTENTIALS ima za cilj temeljito proučavanje autokatalitičkog procesa stvaranja nanočestica putem mehanizama rasta nakon sekundarnog nukleacijskog fenomena potpomognutog plazmonom. Na taj će način nova tehnika sinteze nanočestica biti dostupna. Projekt se sastoji od eksperimentalnog, teorijskog, računalnog i tehnološkog dijela koji ima za cilj duboku karakterizaciju svih uključenih mehanizama. Eksperimenti će se provoditi u španjolskom (CFM) i kanadskom (INRS) laboratoriju. Prvi će pripremiti i istražiti nukleaciju i rast metalnih nanokristala, dok će drugi razviti naprednu optičku postavu temeljenu na THz tehnologijama za otkrivanje lokalnih toplinskih učinaka u tekućoj fazi i smanjenom volumenu (tj. u matrici hidrogela), gdje auto - očekuje se da će kataliza dobiti poticaj. Teorija i proračuni provest će se u Hrvatskoj (IRB) kako bi se dala statistička fizička (mehanička) i nanooptička procjena o tome kako svjetlosno zračenje potiče sekundarnu nukleaciju i rast nanočestica koje slobodno difundiraju u tekućini ili su imobilizirane na gel. Sveukupno, očekivani POTENTIALS rezultati su trostruki: i.) temeljno razumijevanje i eksperimentalno osmišljavanje rasta nanočestica uz pomoć plazmona putem autokatalitičke sekundarne nukleacije; ii.) proučavanje toplinskih učinaka potpomognutih plazmonom u fotokatalizi i njihovog antagonizma (ili sinergije) s generacijama vrućih nosača; iii.) stvoriti alat za plazmoničku katalizu u smanjenom volumenu gdje se može izazvati maksimalna učinkovitost pretvorbe svjetlosne energije u fotokemijske događaje.]]></summary_hr><summary_en><![CDATA[POTENTIALS aims to thoroughly study the auto-catalytic formation process of nanoparticles by growth mechanisms following plasmon-assisted secondary nucleation phenomena. In this way, a new nanoparticle synthesis technique will be made available. The project consists of experimental, theoretical, computational and technological sections aimed at a deep characterization of all the mechanisms involved. The experiments will be conducted in the Spanish (CFM) and Canadian (INRS) laboratories. The former will prepare and investigate on the nucleation and growth of metal nanocrystals, while the second will develop an advanced optical setup based on THz technologies to detect local thermal effects both in liquid phase and reduced volume (i.e. in a hydrogel matrix), where auto-catalysis is expected to receive a boost. Theory and computations will be conducted in Croatia (IRB) to give a statistical physics (mechanistic) and nano-optical assessement of how light irradiation promotes the secondary nucleation and growth of nanoparticles that freely diffuse in a liquid or are immobilized to a gel. Overall, the expected POTENTIALS results are three-fold: i.) to fundamentally understand and devise experimentally a plasmon-assisted nanoparticle growth via autocatalytic secondary nucleation; ii.) delving into plasmon-assisted thermal effects in photocatalysis and their antagonism (or synergy) with hot carrier generations; iii.) to create a tool for plasmonics catalysis in reduced volume where maximum efficiency of light energy conversion into photochemical events may be evoked.]]></summary_en></project><project>
<id>15060</id><title_hr><![CDATA[Novi N-heterocikli i njihovi kompleksi s antitumorskim i antitripanosomskim djelovanjem]]></title_hr><title_en><![CDATA[Novel N-heterocycles and their metal complexes with anticancer and antitrypanosomal activity]]></title_en><user_id>76</user_id><user_firstLast_name>Silvana Raić-Malić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-9420</code><acronim><![CDATA[NHet&MetCom]]></acronim><duration>31.12.2023 - 30.12.2027</duration><status>U tijeku</status><financ_value>193.754,85 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet kemijskog inženjerstva i tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Chemical Engineering and Technology]]></institution_en><team_members_id>3924, 5964, 2714, 23649, 865090, 865559, 865543, 861758, 28746, 864999, 23311, 869596, 871123, </team_members_id><team_members_names><![CDATA[Tatjana Gazivoda Kraljević, Ljubica Glavaš-Obrovac, Marijana Jukić, Sanja Kostrun, Marija Bakija, Silvio Jakopec, Martina Piškor, Anja Rakas, Valentina Rep, Ivana Sokol, John Kelly, Leon Sačer, Petra Kovačec, ]]></team_members_names><keywords_hr><![CDATA[N-heterocikli, purini, pirimidini, feroceni, organometalni spojevi, metalni kompleksi, antiproliferativno, antitripanosomsko djelovanje]]></keywords_hr><keywords_en><![CDATA[N-heterocycles, purines, pyrimidines, ferrocene, organometallic compounds, metal complexes, antiproliferative, antitrypanosomal activity]]></keywords_en><summary_hr><![CDATA[Dušikovi heterocikli su među najvažnijim strukturnim komponentama farmaceutika, među kojima su spojevi izvedeni iz nukleobaza dobili sve veću pozornost u razvoju antitumorskih i antiparazitskih agenasa. Pojava otpornosti, nuspojave i nedostatak selektivnosti kemoterapeutika najčešći su klinički problemi, posebice u liječenju raka i parazitskih infekcija. U projektu je predložen dizajn i sinteza novih 2-supstituiranih benzazola povezanih s hidrofobnim ili hidrofilnim fragmentom preko fenoksimetilenske ili alifatske jedinice koji će utjecati na njihova fizikalno-kemijska svojstva, kao i na antitumorsko i antitripanosomsko djelovanje. Kako bi se poboljšala propusnost membrane i oralna bioraspoloživost spojeva, provest će se sinteza benzazolnih amidoksima i obrnutih amidina. Sinteza purinskih, pirimidinskih derivata i derivata srodnih purinu te pirimidinskih derivata s kondenziranim peteročlanim heteroaromatskim prstenom povezanih s farmakofornim dijelom, poput organometalnog ferocena, kao bioizostera heteroaromatskog i fenilnog prsten, predviđena je s ciljem dobivanja predstavnika s izraženim i selektivnim antitumorskim i antitripanosomskim djelovanjem. Provest će se nadalje sinteza monometalnih i heterometalnih kompleksa odabranih N-heterocikličkih derivata koji mogu djelovati na više meta i time prevladati problem pojave rezistentnosti. Metali će se uvoditi u strukture N-heterocikla koordinacijom preko heteroatoma liganada ili koordinacijom i povezivanjem organometalnih fragmenata preko odgovarajuće razmaknice. Na temelju rezultata testiranja in vitro dobit će se spojevi sa željenim biološkim učinkom. Konačno, provedenim strukturnim modifikacijama u &#39;hit-to-lead&#39; fazi dobit će se predvodni spojevi s odgovarajućim ADME svojstvima te učinkovitim i selektivnim antitumorskim i antitripanosomskim djelovanjem in vitro.]]></summary_hr><summary_en><![CDATA[Nitrogen heterocycles are among the most important structural components of pharmaceuticals, from which nucleobase-derived compounds have received increasing attention in the discovery of anticancer and antiparasitic agents. Resistance to chemotherapy, adverse side effects and lack of selectivity are current clinical problems, especially in the treatment of cancer and parasitic infections. Herein, we propose the design and syntheses of novel 2-substituted benzazoles linked to hydrophobic or hydrophilic residue via phenoxymethylene or aliphatic unit to modulate physicochemical properties, and anticancer and antitrypanosomal activity. To improve membrane permeability and oral bioavailability, the synthesis of benzazole amidoximes and reversed amidines will be performed. The design and synthesis of purine, purine-related, pyrimidine, and five-membered heteroaromatic ring-fused pyrimidine derivatives linked to pharmacophoric moiety, as well as the incorporation of organometallic ferrocene, as a bioisoster for heteroaromatic or phenyl ring, are foreseen with the aim to obtain representatives with pronounced and selective anticancer and antitrypanosomal activity. A tunable designed compounds will also create various possibilities for metal-ligand complexes that could act through multitarget approach, which is recognized to overcome the problem of threatening resistance. The metals will be introduced into the structure of the N-heterocycles by coordination via heteroatoms of ligands or by both coordination and connection of organometallic fragments via an appropriate spacer. Based on the results of in vitro screening, hit molecules with desired biological effect will be obtained. Finally, structure modification in the hit-to-lead phase will allow the identification of lead molecules with desirable drug profile regarding in vitro antitumor and/or antitrypanosomal activity, cytotoxicity and ADME properties.]]></summary_en></project><project>
<id>15063</id><title_hr><![CDATA[Moralni napredak: individualni i kolektivni]]></title_hr><title_en><![CDATA[Moral Progress: Individual and Collective]]></title_en><user_id>2690</user_id><user_firstLast_name>Tvrtko Jolić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-5341</code><acronim><![CDATA[MoPIC]]></acronim><duration>31.12.2023 - 30.12.2027</duration><status>U tijeku</status><financ_value>102.957,02 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filozofija, </scie_field_hr><scie_field_en>Philosophy, </scie_field_en><institution_hr><![CDATA[Institut za filozofiju]]></institution_hr><institution_en><![CDATA[Institute for Philosophy in Zagreb]]></institution_en><team_members_id>242, 861686, 22529, 865694, 29263, 25046, 870059, 872785, 872998, </team_members_id><team_members_names><![CDATA[Filip Grgić, Viktor Ivanković, Matej Sušnik, Lovro Grgić, Tomislav Bracanović, Karolina Kudlek, Stipe Buzar, Charlie Blunden, Monika Zeba, ]]></team_members_names><keywords_hr><![CDATA[Moralni napredak, emocije, metaetika, moralna odgovornost, moralno biopoboljšanje, bihevioralni utjecaji, pojedinci, kolektivi.]]></keywords_hr><keywords_en><![CDATA[Moral progress, emotions, metaethics, moral responsibility, moral bioenhancement, nudges, individuals, collectives.]]></keywords_en><summary_hr><![CDATA[Polazeći od stajališta da je moral složeni sustav koji počiva na spoznajnim, afektivnim i bihevioralnihm elementima, naše istraživanje cilja istražiti i razmotriti ulogu koju ti elementi imaju u procesima moralnoga napredovanja ili nazadovanja. To ćemo učiniti ispitujući oblike i karakteristike individualnog i kolektivnog moralnog razvoja kako bismo ustanovili sličnosti i razlike između ta dva oblika moralnog razvoja kao i njihovu povezanost i međusobni utjecaj. Osnovna hipoteza istraživanja glasi da su individualni i kolektivni moralni napredak dvije odvojene vrste moralnog napretka, ali da su ovisni jedan o drugomu i da se, u povoljnim okolnostima, međusobno podupiru. Istraživanje namjeravamo provesti u četiri različita ali međusobno povezana segmenta. U prvome segmentu istražit će se moralni napredak pojedinaca pri čemu će se poseban naglasak staviti na ulogu emocija u moralnom napretku. Drugi segment posvećen je razmatranju kolektivnog moralnog napretka. Ovaj dio istraživanja ima dvije zadaće: 1.) utvrditi za koje vrste kolektiva možemo tvrditi da moralno napreduju ili nazaduju i 2.) utvrditi ulogu moralne refleksije u moralnom napretku. Treći segment istraživanja bavi se međusobnim odnosom individualnog i kolektivnog moralnog napretka i razmatranjem bihevioralnog aspekta moralnog napretka. Na kraju, zadaća četvrtog segmenta istraživanja jest da istraživačke uvide o individualnom i kolektivnom moralnom napretku smjesti u odgovarajući metaetički i evolucijski okvir.]]></summary_hr><summary_en><![CDATA[Starting from the assumption that morality is a complex system that rests on cognitive, affective, and behavioural elements, our research aims to explore and consider the role of these elements in moral progress and regress. We go about this task by assessing the forms and properties of individual and collective moral development in order to determine the similarities and differences between these two kinds of moral development, as well as their relatedness and mutual influence. The main research hypothesis states that individual and collective moral progress are two distinct kinds of moral progress, yet they are mutually dependent and reinforce one another in favourable circumstances. The research project is to be carried out in four distinct, yet interwoven tracks. As part of the first track, we explore the moral progress of individuals with a particular emphasis on the role of emotions in moral progress. The second track considers collective moral progress, setting itself with two tasks: 1) to determine the kinds of collectives that could be considered agents of moral progress or regress; 2) to determine the role of moral reflection in moral progress. The third research track deals with the correlation between individual and collective moral progress, as well as with exploring the behavioural aspect of moral progress. Finally, the fourth research track aims to incorporate the resulting insights about individual and collective moral progress into a metaethical and evolutionary frame. Each research track is elaborated in further detail below.]]></summary_en></project><project>
<id>15065</id><title_hr><![CDATA[Utjecaj okolišnih čimbenika na sastav zajednica gljiva mediteranske regije Hrvatske ]]></title_hr><title_en><![CDATA[Environmental drivers of fungal community composition in the Mediterranean region of Croatia]]></title_en><user_id>19224</user_id><user_firstLast_name>Armin Mešić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-5219</code><acronim><![CDATA[FunMed]]></acronim><duration>31.12.2023 - 30.12.2027</duration><status>U tijeku</status><financ_value>197.610,99 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Interdisciplinarne prirodne znanosti, Kemija, Biologija, Geofizika, </scie_field_hr><scie_field_en>Interdisciplinary natural sciences, Chemistry, Biology, Geophysics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>5710, 26553, 865066, 13120, 866122, 6636, 866084, 19027, 12438, 869790, </team_members_id><team_members_names><![CDATA[Zdenko Tkalčec, Ana Pošta, Lucia Pole, Neven Matočec, Tijana Martinović, Tamara Jakovljević, Carles Castano Soler, Nataša Hulak, Željko Zgrablić, Antonela Blažević, ]]></team_members_names><keywords_hr><![CDATA[biogeografija, bioraznolikost, eDNA metabarkodiranje, ekologija, gljive, klimatske promjene, okolišni uzorci, šume, tlo]]></keywords_hr><keywords_en><![CDATA[biodiversity, biogeography, climate changes, ecology, eDNA metabarcoding, environmental samples, fungi, forests, soil]]></keywords_en><summary_hr><![CDATA[Najveći broj gljiva svoj životni prostor nalazi u šumskim staništima gdje obavljaju mnoge važne ekološke uloge kojima uvelike doprinose stabilnosti cijelih ekosustava. Važnost i razina utjecaja brojnih okolišnih čimbenika na bogatstvo, sastav i funkcionalnu raznolikost zajednica gljiva nedovoljno je poznata. Na području Hrvatske, bioraznolikost gljiva u mediteranskoj regiji najslabije je istražena te stoga čini fokus ovog projekta. Glavni cilj je identificirati utjecaj okolišnih čimbenika (kemijska svojstva tla te mikroklimatski parametri - temperatura, vlaga) na prostorne i vremenske promjene u biomasi, raznolikosti i funkcionalnom sastavu zajednica gljiva tla i listinca u šumskim staništima mediteranske regije Hrvatske. Temeljna istraživačka metoda identifikacije bioraznolikosti gljiva u projektu je DNA metabarkodiranje okolišnih uzoraka (eDNA) putem tehnologije sekvenciranja visoke propusnosti. Provedena istraživanja ispunit će prazninu u poznavanju biogeografije gljiva šumskih ekosustava istraživanog područja, kao i južne Europe te omogućiti kvalitetnije sagledavanje okolišnih čimbenika koji oblikuju obrasce rasprostranjenosti gljiva na globalnoj razini. Spoznaja o bioraznolikosti gljiva šumskih staništa i okolišnim čimbenicima koji oblikuju njenu rasprostranjenost jedan je od preduvjeta za adekvatno vrednovanje, održivo korištenje i očuvanje ovih, vrlo vrijednih, bioloških resursa i za buduće generacije.]]></summary_hr><summary_en><![CDATA[Most of fungal species inhabit forest areas, where they perform many important ecological functions that contribute significantly to the stability of entire ecosystems. The importance and extent of the influence of numerous environmental factors on the richness, composition, and functional diversity of fungal communities are poorly understood. In Croatia, the biodiversity of fungi in the Mediterranean region is the least studied and is therefore investigated by this project. The main objective is to determine the influence of environmental factors (soil chemical properties and microclimatic parameters - temperature, humidity) on spatial and temporal changes in biomass, diversity, and functional composition of soil and litter fungal communities in forest habitats of the Mediterranean region of Croatia. The research method used for the identification of fungal taxa in the project is DNA metabarcoding of environmental samples (eDNA) based on high-throughput sequencing technology. The project results will fill the gap in our knowledge of the fungal biogeography of forest ecosystems in Croatia and in southern Europe as a whole, and will provide a better overview of the environmental factors shaping fungal distribution patterns on a global scale. Knowledge of fungal biodiversity and the environmental factors that influence its distribution is one of the prerequisites for appropriate assessment, sustainable use and conservation of highly valuable forest resources for future generations.]]></summary_en></project><project>
<id>15071</id><title_hr><![CDATA[Digitalni podatci, infrastrukture i razvoj]]></title_hr><title_en><![CDATA[Digital data, infrastructures, and development]]></title_en><user_id>1329</user_id><user_firstLast_name>Paško Bilić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-2780</code><acronim><![CDATA[DEVELOPER]]></acronim><duration>31.12.2023 - 30.12.2027</duration><status>U tijeku</status><financ_value>115.080,50 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Interdisciplinarne društvene znanosti, Ekonomija, Pravo, Informacijske znanosti, Sociologija, </scie_field_hr><scie_field_en>Interdisciplinary social sciences, Economy, Law, Information sciences, Sociology, </scie_field_en><institution_hr><![CDATA[Institut za razvoj i međunarodne odnose]]></institution_hr><institution_en><![CDATA[Institute for Development and International Relations]]></institution_en><team_members_id>13241, 5678, 865974, 11230, 866180, 12897, 866189, 5689, 871127, 18914, 873020, </team_members_id><team_members_names><![CDATA[Krešimir Krolo, Antonija Petričušić, Toni Prug, Jaka Primorac, Valentina Vučković, Mislav Žitko, Tomislav Medak, Iva Nenadić, Emina Buzinkic, Marija Brajdić Vuković, Nikolina Rajković, ]]></team_members_names><keywords_hr><![CDATA[Digitalni podatci, infrastrukture, platforme, institucije, organizacije, svakodnevica, razvoj]]></keywords_hr><keywords_en><![CDATA[Digital data, infrastructures, platforms, institutions, organizations, everyday life, development]]></keywords_en><summary_hr><![CDATA[Digitalni podatci distribuirani s pomoću internetskih platformi, pametnih telefona i drugih naprava postali su izvor intenzivne komercijalizacije i razvoja javnih infrastruktura u razvijenim zemljama. Podatci su nužni za razvoj algoritama kojima se strojnim učenjem i obradom prirodnog jezika konstruira umjetna inteligencija, zamjenjuje spora ručna obrada podataka i pružaju novi analitički uvidi. S obzirom na to da sve više podataka postaje dostupno u digitalnim formatima, često se tvrdi da će podatci postati pokretač ekonomskog rasta i dobrobiti. Međutim, ekonomski i društveni razvoj nije izravna primjena računalnih metoda, nego složen proces koji ovisi o brojnim društvenim čimbenicima. Razumijevanje uloge podataka u društvu predmet je intenzivnih rasprava i istraživanja infrastruktura te kritičkih istraživanja podataka i platformi. Projektom DEVELOPER provest će se interdisciplinarna analiza iz perspektive društvenih znanosti. Istražit će se uloga podataka u društvu na razini institucija (zakona i tržišta), organizacija (privatnih i javnih) i svakodnevnog života građana. Pritom će se izbjegavati utopijska i distopijska razmišljanja o velikim podatcima kako bi se empirijski istražilo čimbenike koji unaprjeđuju ili sprječavaju razvoj podatkovnih infrastruktura i njihovu ulogu u stvaranju privatnog i javnog bogatstva. Primijenit će se eksplorativni, sekvencijalni idejni nacrt mješovitih metoda sa svrhom razumijevanja normi, vrijednosti, iskustava i praksa povezanih s digitalnim podatcima i podatkovnim infrastrukturama. Unaprijedit će se i poboljšati znanje u znanstvenoj zajednici o podatkovnim infrastrukturama u postsocijalističkim zemljama ekonomske periferije Europske unije. Empirijskim istraživanjima doprinijet će se daljnjem razvoju strateških planova Europske komisije i Nacionalne razvojne strategije kako bi se omogućila bolja regulacija, poboljšali organizacijski i radni uvjeti i građani uključili u digitalne usluge.]]></summary_hr><summary_en><![CDATA[Digital data circulated through internet platforms, smartphones, and other devices have become the source of intense commercial activity and public infrastructure advancement in developed countries. Data is an essential input for algorithms, enabling the construction of artificial intelligence with the help of machine learning and natural language processing while replacing manual, time-consuming data management and providing new analytical insights. As more digital data becomes available, it is often said to be the driver of economic growth and well-being. However, economic and social development is not a straightforward implementation of computational techniques but a process dependent on multiple social factors. Understanding the role of data in society has been the focus of intense debate in infrastructure studies, critical data studies and platform studies. The DEVELOPER project will provide an interdisciplinary social science analysis. It aims to examine the role of digital data in society at the level of institutions (law and markets), organisations (private and public), and the everyday life of citizens. We will move away from utopian or dystopian visions of (big) data and empirically explore factors that foster or hinder the development of data infrastructures, including their role in producing private and public wealth. The Project will follow an exploratory, sequential, mixed-methods research design to understand norms, values, experiences, and practices attributed to digital data and data infrastructures. It will advance knowledge in the scientific community and provide a better understanding of data infrastructures in the post-socialist economic periphery of the European Union. Assessments based on empirical research will further develop strategic plans outlined by the European Commission and the Croatian National Development Strategy, foster regulatory oversight, improve organisational and working conditions, and include citizens in digital services. ]]></summary_en></project><project>
<id>15075</id><title_hr><![CDATA[Međudjelovanje svjetlosti i atomski tankih struktura na nano-skali]]></title_hr><title_en><![CDATA[Nanoscale interaction of light and atomically thin structures]]></title_en><user_id>13782</user_id><user_firstLast_name>Marko Kralj</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-4724</code><acronim><![CDATA[nmfs2D]]></acronim><duration>01.02.2024 - 31.01.2028</duration><status>U tijeku</status><financ_value>198.550,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut za fiziku]]></institution_hr><institution_en><![CDATA[Institute of Physics in Zagreb]]></institution_en><team_members_id>3090, 5785, 6225, 28810, 865910, 865747, 869746, 19881, </team_members_id><team_members_names><![CDATA[Iva Šrut Rakić, Marin Petrović, Nataša  Vujičić, Ana Senkić, Christian Teichert, Marko Spasenovic, Sabina Špoljar, Borna Pielić, ]]></team_members_names><keywords_hr><![CDATA[2D materijali, 2D heterostrukture, mikroskopija i spektroskopija bliskog polja, ultrabrza dinamika, optoelektronika, nanofotonika]]></keywords_hr><keywords_en><![CDATA[2D materials, 2D heterostructures, near-filed imaging and spectroscopy, ultrafast dynamics, optoelectronics, nanophotonics]]></keywords_en><summary_hr><![CDATA[U okviru istraživačkog projekta &#39;&#39;Međudjelovanje svjetlosti i atomski tankih struktura na nano-skali&#39;&#39; nastojimo doći do značajnih novih spoznaja o optičkim svojstvima na nanometarskoj razini za materijale bazirane na dvodimenzionalnim (2D) atomski tankim slojevima i strukturama. To se odnosi na karakterizaciju optičkog odgovora na nano-skali i dobivanja uvida u bogatu fiziku međudjelovanja kvazičestica s elektromagnetskim poljem, što je spoj kvantnih materijala u čvrstom stanju i kvantne optike. Oslanjamo se na veliku stručnost u sintezi i izradi visokokvalitetnih 2D materijala, koja je još više ojačana međunarodnom suradnjom u okviru ovog projekta. Središnji dio ovog istraživanja posvećen je optičkom snimanju i spektroskopiji u nano-skali pomoću efekta bliskog polja, jedinstvenoj tehnici koja pruža prostornu rezoluciju od 10 nm neovisnu o valnoj duljini. Unutar ovog projekta planiramo nadograditi funkcionalnost našeg sustava bliskog polja s-SNOM, za oslikavanje u vidljivom području. Također planiramo zaposliti jednog novog postdoktoranda i dva  doktoranda, koji će se pridruže ovom uzbudljivom istraživanju unutar SIMAT istraživačke grupe na Institutu za fiziku.]]></summary_hr><summary_en><![CDATA[In the scope of the research project &#39;&#39;Nanoscale interaction of light and atomically thin structures,&#39;&#39; we aim to reach substantial new knowledge on the nanoscale optical properties of nanomaterials based on two-dimensional (2D) atomically thin layers and structures. This regards characterization of the optical response at the nanoscale and getting insight into the rich physics of quasiparticle interactions with an electromagnetic field, which is a combination of solid-state quantum materials and quantum optics. We rely on strong expertise in the synthesis and fabrication of high-quality 2D materials, which is even more strengthened by international collaboration within this project. The central part of this research is dedicated to near-field nanoscale optical imaging and spectroscopy, a unique technique that provides wavelength independent 10 nm spatial resolution. Within this project, we plan to upgrade the functionality of our s-SNOM near-field system to near-field imaging in the visible range. We also plan to employ one new postdoc and two Ph.D. students to join this exciting research within SIMAT research group at the Institute of Physics.]]></summary_en></project><project>
<id>15083</id><title_hr><![CDATA[Singularna perturbacija i asimptotička analiza rubnih problema za parcijalne diferencijalne jednadžbe]]></title_hr><title_en><![CDATA[Singular perturbation and asymptotic analysis of boundary value problems for partial differential equations]]></title_en><user_id>1462</user_id><user_firstLast_name>Eduard Marušić-Paloka</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-1091</code><acronim><![CDATA[Asyan]]></acronim><duration>18.12.2023 - 17.12.2027</duration><status>U tijeku</status><financ_value>128.504,07 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, Fizika, Geologija, Kemija, Biologija, Geofizika, Interdisciplinarne prirodne znanosti, </scie_field_hr><scie_field_en>Mathematics, Physics, Geology, Chemistry, Biology, Geophysics, Interdisciplinary natural sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>817, 4816, 22664, 3424, 23314, 869717, 858439, 872968, </team_members_id><team_members_names><![CDATA[Igor Pažanin, Josip Tambača, Marko Radulović, Andrijana Ćurković, Matko Ljulj, Luka Tolj, Borja Rukavina, Jelena Dujella, ]]></team_members_names><keywords_hr><![CDATA[Asimptotička analiza, Singularna perturbacija, Matematičko  modeliranje, mehanika kontinuuma, Homogenizacija, Rubni problemi, PDJ]]></keywords_hr><keywords_en><![CDATA[Asymptotic analysis, Singular perturbation, Mathematical modelling, Continuum mechanics, Homogenization, Boundary value problems, PDE]]></keywords_en><summary_hr><![CDATA[Cilj projekta je proučavanje rubnih problema za jednadžbe matematičke fizike koji ovise o jednom ili više malih parametara. Ovisnost može biti kroz koeficijente u jednadžbama i rubnim uvjetima ili kroz geometriju područja u kome se proces odvija. Primjerice područje može biti tanko (cijev, štap, pukotina, ploča, ljuska,...). Može biti i porozno ili heterogeno s poroznošću ili heterogenošću ovisnom o nekom malom parametru. Isto tako i rub područja može biti porozan ili hrapav s hrapavošću ili poroznošću ovisnom o nekim malim parametrima. Asimptotička analiza takvih problema, s obzirom na male parametre ima za cilj odrediti ovisnost rješenja o tim parametrima, kad je njihova vrijednost blizu nuli. Kad se ta ovisnost utvrdi, pojednostavljeni model za opisivanje promatrane fizikalne situacije može se izvesti i opravdati. Perturbacija problema malim parametrom je regularna ako je u modelu moguće  uzeti da je vrijednost malog parametra nula, te se time dobije smisleni problem čije je rješenje blisko rješenju originalnog problema. U protivnom, kažemo da je perturbacija singularna. Takvi su problemi, najčešće, složeni za numeričko rješavanje te je poželjna, a nekad i nužna, dodatna analiza problema prije rješavanja, koja pomaže i boljem razumijevanju fizikalnog procesa. Moderna asimptotička analiza singularno perturbiranih problema zahtijeva duboko poznavanje klasičnih matematičkih disciplina poput diferencijalnih jednadžbi i funkcionalne analize. Pripadne simulacije zahtijevaju kompleksne metode. Proučavati ćemo nekoliko takvih problema metodama asimptotičke analize:C1: Izvod novih modela za opisivanje viskoznog toka u području s poroznim rubom i analiza njihove rješivosti.C2: Novi modeli za opisivanje procesa izmjene topline između cijevi i njene okoline.C3: Izvod modela i analiza svojstava modela konstrukcija Naghdijevog tipa.C4: Izvod i opravdanje novih modela za tokove kroz porozne sredine s velikom poroznošću, koje su potpuno ispunjene fluidom.]]></summary_hr><summary_en><![CDATA[The goal of this project is to study boundary value problems for the equations of mathematical physics (mainly continuum mechanics) that depend on some very small parameter. The dependence can be through some coefficient in the equation or boundary condition, or through the geometry of the domain. For example, the domain can be thin porous or heterogeneous, with porosity or heterogeneity depending on some small parameter. Its boundary can be rough or porous, depending on some small parameter. Asymptotic analysis of such problems, aims to determine the dependence of the solutions on small parameter(s) as they, approach zero. Once that is established, a simplified model for describing the considered physical situation can be derived and justified.The perturbation of the problem, by small parameter, is considered singular if it makes no sense to replace the small parameter by zero, or it does not give a good approximation of the original problem. Such problems are complex for numerical solution, and it is useful, if not necessary, to do some prior analysis. It also helps to understand the physical process. Asymptotic analysis of such problems requires deep knowledge of classical mathematical fields, such as differential equations, functional analysis, general topology as well as differential geometry. Simulations of those problems involve complex computational methods.We plan to study several problems that require singular perturbation methods and asymptotic analysis: C1: Derivation of new models for describing a viscous flow in domain with porous boundary and analysis of their solvability.C2: New models for heat exchange process between a pipe and its surrounding domainC3: Derivation of of Naghdi type structure models and analysis of their propertiesC4: Derivation and justification of new models for flows through domains filled with a fluid-saturated sparsely packed porous medium]]></summary_en></project><project>
<id>15087</id><title_hr><![CDATA[Teorija brojeva i aritmetička geometrija]]></title_hr><title_en><![CDATA[Number theory and arithemtic geometry]]></title_en><user_id>2910</user_id><user_firstLast_name>Filip Najman</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-5008</code><acronim><![CDATA[TEBAG]]></acronim><duration>31.12.2023 - 30.12.2027</duration><status>U tijeku</status><financ_value>166.022,97 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>95, 1348, 865211, 1312, 17746, 2990, 23916, 1262, 865743, 3264, 3767, 1264, 4086, 2600, 868290, 868529, 867640, 868614, 874055, </team_members_id><team_members_names><![CDATA[Andrej Dujella, Ivan Soldo, Petar Orlić, Sanda Bujačić Babić, Marija Bliznac Trebješanin, Tomislav Pejković, Goran Drazic Drazic, Alan Filipin, Alen Andrašek, Mirela Jukić Bokun, Matija Kazalicki, Ana Jurasić, Nikola Adžaga, Zrinka Franušić, Ivan Novak, Lukas Novak, Pavao Radić, Maarten Derickx, Marin Varivoda, ]]></team_members_names><keywords_hr><![CDATA[Teorija brojeva, Diofantov D(n)-m-torke, modularne krivulje, separacija korijena polinoma, kongruencije modularnih formi, duboko učenje]]></keywords_hr><keywords_en><![CDATA[Number theory, Elliptic curves, Diophantine m-tuples, modular curves, polynomial root separataion, congruences of modular forms, deep learning]]></keywords_en><summary_hr><![CDATA[Predloženim projektom koordinirat će se i podržat istraživačke aktivnosti hrvatske grupe iz teorije brojeva i aritmetičke geomtrije. Teme istraživanja su: Aritmetika modularnih krivulja, Diofantove D(n)-m-torke, Diofantske aproksimacije, Primjena dubokog učenja u teoriji brojeva i Kongruencije za sporadične nizove i modularne forme. U aritmetici modularnih krivulja ćemo se baviti gonalnostima modularnih krivulja, određivanju mogućih torzijskih grupa i stupnjeva izogenija eliptičkih krivulja nad poljima malog stupnja, te primjenama na Diofantske jednadžbe. Diofantov D(n)-m-torke ćemo promatrati nad cijelim brojevima, nad kvadratnim poljima, te nad polinimijalnim prstenima. U Diofantskim aproksimacijama ćemo se baviti separacijom korijena polinoma s malo članova, i s p-adskim verižnim razlomcima. Duboko učenje planiramo primjeniti na traženje eliptičkih krivulja s velikim rangovima. ]]></summary_hr><summary_en><![CDATA[The proposed project will coordinate and support the research activities of the Croatian group in number theory and arithmetic geometry. Research topics are: Arithmetic of modular curves, Diophantine D(n)-m-tuples, Diophantine approximations, Application of deep learning in number theory and Congruences for sporadic sequences and modular forms. In the arithmetic of modular curves, we will deal with the gonalities of modular curves, the determination of possible torsion groups and degrees of isogenies of elliptic curves over fields of small degree, and applications to Diophantine equations. We will study Diophantine D(n)-m-tuples over integers, over quadratic fields, and over polynomial rings. In Diophantine approximations, we will deal with the separation of roots of polynomials with few terms, and with p-adic continued fractions. We plan to apply deep learning to the search for elliptic curves with large ranks.]]></summary_en></project><project>
<id>15089</id><title_hr><![CDATA[Precizna digitalizirana spektroskopija u fundamentalnim istraživanjima u subatomskoj fizici i primjenama]]></title_hr><title_en><![CDATA[High-precision digitized spectroscopy in fundamental research in subatomic physics and applications]]></title_en><user_id>3809</user_id><user_firstLast_name>Damir Bosnar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-3878</code><acronim><![CDATA[PREDISPECT]]></acronim><duration>18.12.2023 - 17.12.2027</duration><status>U tijeku</status><financ_value>145.119,12 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>1479, 4413, 4395, 858418, 864949, 4993, 865674, 22715, 866738, </team_members_id><team_members_names><![CDATA[Mihael Makek, Petar Žugec, Ivica Friščić, Tomislav Bokulić, Om Prakash Dash, Catalina Oana Curceanu, Alessandro Scordo, Luka Pavelić, Siddharth Parashari, ]]></team_members_names><keywords_hr><![CDATA[pozitronska fizika, kvantna fizika, hadronska fizika, neutronske interakcije, medicinsko oslikavanje, digitalizatori]]></keywords_hr><keywords_en><![CDATA[positron physics, quantum physics, hadron physics, neutron interactions, medical imaging, digitizers]]></keywords_en><summary_hr><![CDATA[Projekt obuhvaća nekoliko vrlo značajnih tema u subatomskoj fizici i primjenama u medicinskom oslikavanju: 1) istraživanje eventualnog, do sada neopaženog, CP i CPT narušenja u leptonskom sektoru kroz prvo mjerenje specifičnih asimetrija gama zraka u anihilaciji orto-pozitronija koje će biti napravljeno na Fizičkom odsjeku u Zagrebu, 2) istraživanja kvantnih korelacija (sprege) u tro-čestičnima sustavima  s fotonima u MeV-skom području kroz prvo mjerenje distribucija polarizacija tri spregnute gama zrake iz anihilacije orto-pozitronija koje će biti napravljeno na Fizičkom odsjeku, 3) proučavanja X-zraka iz prijelaza u plinskim kaonskim atomima na sudaraču DAPHNE u Laboratori Nazionali di Frascati od interesa u nisko-energijskoj QCD kao i X-zraka iz prijelaza u težim kaonskim atomima u za precizno određivanje kaonske mase, 4) proučavanja neutronski induciranih reakcija na jezgrama na n_TOF postrojenju na CERN-u tipa natC(n,p) i  natC(n,d) koje su od medicinskog i tehnološkog interesa kao i (n,gama) vrste koje su od astrofizičkog značenja i 5) studija uporabe polarizacijskih korelacija gama zraka u PET-u s vremenom proleta za dobivanje osjetljivijeg i cjenovno efikasnijeg PET-a koja će biti provedena na Fizičkom odsjeku. Zajedničko svojstvo svih predloženih tema istraživanja je uporaba nove kompaktne digitalne elektronike (digitalizatora) s izvrsnim performanasama koja ili sprema kompletan signal iz detektora za off-line analizu ili/i ima raznovrsne mogućnosti procesiranja signala. U posljednjem desetljeću takva elektronika doživljava vrlo dinamičan razvoj i danas pruža mogućnosti za složena mjerenja koja bi inače bila vrlo teško ili čak neizvediva s konvencionalnom analognom elektronikom. Praćena naprednim tehnikama analize podataka omogućava izvođenje sofisticiranih, vrlo preciznih mjerenja na samoj fronti istraživanja u subatomskoj fizici  i na malim sveučilišnim odjelima. ]]></summary_hr><summary_en><![CDATA[The project comprises several very significant topics in subatomic physics and applications in medical imaging: 1) investigations of tentative and until now not observed CP and CPT symmetry breaking in leptonic sector by first measurement of specific asymmetry of gamma rays in ortho-positronium (o-PS) annihilation which will be performed at Department of Physics in Zagreb, 2) investigations of quantum correlations (entanglement) in three-party system of photons in MeV region by first measurement of distributions of polarizations of three entangled gamma rays from o-PS annihilation which will be performed at Department of Physics, 3) investigations of X-ray transitions in gaseous kaonic atoms at DAPHNE collider at Laboratori Nazionali di Frascati of interest for low energy QCD as well as X-ray transitions in kaonic atoms of heavier targets to precisely determine the charged kaon mass, 4) investigations of neutron induced reactions  on nuclei at n_TOF facility at CERN of natC(n,p) and  natC(n,d)  type which are of medical and technological interest as well as (n,gamma) reactions which are of astrophysical significance  and 5) study of utilization of polarization correlations of gamma-rays in time-of-flight PET to achieve more sensitive and cost-effective PET which will be performed at Department of Physics. A common feature of all proposed topics is application of novel, high-performance and compact digital electronics (digitizers), which either store complete signals from the detectors for the off-line analysis or/and have versatile signal processing capabilities. They have experienced very dynamic development in the last decade and nowadays provide opportunities for complex measurements which would be very difficult, if not impossible, with conventional analogue electronics. Accompanied with advanced data analysis techniques they enable execution of sophisticated, high-precision and state-of-the-art experiments in subatomic physics  at small university departments.]]></summary_en></project><project>
<id>15092</id><title_hr><![CDATA[Foto-osjetljive kvantne strukture za primjenu u senzorima, fotoćelijama i  cijepanju vode]]></title_hr><title_en><![CDATA[Photo-sensitive quantum structures for application in sensors, solar cells and water splitting]]></title_en><user_id>1362</user_id><user_firstLast_name>Maja Mičetić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-3765</code><acronim><![CDATA[FoKs]]></acronim><duration>15.12.2023 - 14.12.2027</duration><status>U tijeku</status><financ_value>169.398,10 eur</financ_value><scie_area_hr>Prirodne znanosti, Biomedicina i zdravstvo, Tehničke znanosti, </scie_area_hr><scie_area_en>Natural sciences, Biomedicine and health sciences, Technological sciences, </scie_area_en><scie_field_hr>Interdisciplinarne prirodne znanosti, </scie_field_hr><scie_field_en>Interdisciplinary natural sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>3526, 5657, 2755, 3154, 3630, 23459, 864982, 865363, 24100, 6157, 865408, 866261, 23403, 865362, 869889, </team_members_id><team_members_names><![CDATA[Tihomir Car, Krešimir Salamon, Ivančica Bogdanović Radović, Igor Mekterović, Ljiljana Brkić, Joško Erceg, Ivana Periša, Gabrijela Svalina, Dario Mičetić, Mateja Janković Makek, Marija Šimat, Peter Siffalovic, Božidar Benko, Senad Isaković, Kripesh K.V, ]]></team_members_names><keywords_hr><![CDATA[Kvantne točke, Nanomaterijali, Senzori, Solarne ćelije, cijepanje vode, nanotehnologija]]></keywords_hr><keywords_en><![CDATA[Quantum dots, Nanomaterials, Sensors, Solar cells, Water splitting, Nanotechnology]]></keywords_en><summary_hr><![CDATA[Primjena materijala baziranih na kvantnim strukturama u nanotehnologiji, a posebno u foto-osjetljivim uređajima, spada u jedno od najvažnijih područja znanstvenih istraživanja. Poznato je da poluvodičke kvantne stukture imaju jedinstvena optička i električna svojstva zbog efekata kvantnog zatočenja na nosioce naboja u njima. Stoga njihov energetski procijep ovisi o građi, obliku i veličini kvantnih struktura, te ga je moguće kontrolirano mijenjati. Efekti zatočenja su posebno jaki u jezgra/ljuska kvantnim strukturama gdje su često elektroni i šupljine prostorno separirani. Sljedeći vrlo značajan efekt je generacija višestrukih ekscitona pri pobudi jednim fotonom. Zbog njega se dobiva stupanj konverzije upadnog fotona u elektrone (kvantna efikasnost) veći od 100% za neke energije fotona. Ovaj efekt je posebno značajan za foto-osjetljive uređaje.Osnovni cilj projekta je iskoristiti i usavršiti gore navedena svojstva foto-osjetljivih kvantnih struktura baziranih na germaniju za izradu efikasnih senzora, detektora, solarnih ćelija i uređaja za cijepanje vode. Naša dosadašnja istraživanja rezultirala su serijom takvih materijala sastavljenih od prostorno uređenih mreža Ge kvantnih struktura u raznim dielektričnim matricama. U te materijale spadaju 3D mreže od Ge, Ge/Si i Ge/metal jezgra/ljuska kvantne točake i Ge kvantne žice. Oni pokazuju energijski procijep u rasponu od 0.7 - 3 eV, apsorpciju u području IR od UV, vrlo jaku foto-generiranu struju (omjer svjetlo/mrak preko 10^5), te iznimno izražen efekt generacije višestrukih ekscitona, osim vrlo zanimljive strukture. Osim toga, ove kvantne strukture su uronjene u matrice, te su vrlo stabilne i bezopasne za zdravlje. Istraživanje se temelji na materijalima koji su po svim svojstvima izvrsni za primjenu u foto-osjetljivim uređajima, a za sada je njihova primjena posve neistražena. Naša velika prednost je što smo razvili te materijale, te znamo kako ih kontrolirano napraviti i uspješno karakterizirati.]]></summary_hr><summary_en><![CDATA[The development of materials based on quantum structures (QS) in nanotechnology, and especially in photo-sensitive devices, belongs to one of the most important areas of scientific research. Semiconductor QS are known to have unique optical and electrical properties due to quantum confinement effects on the charge carriers in them. Therefore, their energy gap depends on the structure, shape and size of the QS, and it is possible to change it in a controlled manner. Confinement effects are particularly strong in core/shell QS where electrons and holes are often spatially separated. The next very significant effect is the generation of multiple excitons upon excitation by a single photon. Because of it, the degree of conversion of the incident photon into electrons (quantum efficiency) is greater than 100% for some photon energies. This effect is particularly significant for photosensitive devices.The main goal of the project is to use and develop the above-mentioned properties of photosensitive QS based on germanium for the production of efficient sensors, detectors, solar cells and devices for splitting water. Our research so far has resulted in a series of such materials composed of spatially ordered networks of Ge QS in various dielectric matrices. These materials include 3D networks of Ge, Ge/Si and Ge/metal core/shell quantum dots and Ge quantum wires. They show an energy gap in the range of 0.7 - 3 eV, absorption in the IR to UV region, a very strong photo-generated current (light/dark ratio over 10^5), and an extremely pronounced multiple exciton generation effect, in addition to a very interesting structure. In addition, these QSs are immersed in matrices, and are very stable and harmless to health.This research relays on materials that are excellent in all their properties for use in photo-sensitive devices. Their application is still completely unexplored. Our advantage is that we have developed them, so we know how to prepare and characterize them.]]></summary_en></project><project>
<id>15094</id><title_hr><![CDATA[Oštećenje DNA i diferencijacija akutne mijeloične leukemije]]></title_hr><title_en><![CDATA[DNA damage and differentiation of acute myeloid leukemia]]></title_en><user_id>4677</user_id><user_firstLast_name>Dora Višnjić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-9146</code><acronim><![CDATA[DD&D_in_AML]]></acronim><duration>18.12.2023 - 17.12.2027</duration><status>U tijeku</status><financ_value>196.820,00 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, Clinical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>4042, 4499, 4676, 4837, 19576, 25651, 861749, 869782, 872941, </team_members_id><team_members_names><![CDATA[Radovan Vrhovac, Drago Batinić, Hrvoje Lalić, Vilma Dembitz, Josip Batinić, Antonio Bedalov, Tomislav Smoljo, Alojzija Brčić, Klara Bardač, ]]></team_members_names><keywords_hr><![CDATA[AML, oštećenje DNA, Chk1, AIKAr, pirimidin, citarabin]]></keywords_hr><keywords_en><![CDATA[AML, DNA damage, Chk1, AICAr, pyrimidine, cytarabine]]></keywords_en><summary_hr><![CDATA[Glavno obilježje akutne mijeloične leukemije (AML) je izostanak diferencijacije pa je stoga poticanje diferencijacije izgledni pristup liječenju. Najuspješniji primjer diferencirajućeg liječenja je liječenje akutne promijelocitne leukemije (APL) pomoću sve-trans retinske kiseline (ATRA). Nedavni uspjeh inhibitora mutirane izocitrat-dehidrogenaze obnovio je zanimanje za diferencirajuće liječenje, a učinci inhibitora dihidroorotat-dehidrogenaze (DHODH) se aktivno istražuju.  Naša istraživačka skupina ima dugogodišnje iskustvo u istraživanju mehanizama diferencijacije leukemija. Naša nedavna istraživanja otkrila su da  5-aminoimidazol-4-karboksiamid ribonukleozid (AICAr) potiče diferencijaciju monocitnih linija AML te podskupine primarnih blasta izoliranih iz koštane srži (KS) oboljelih od AML. AIKAr koči sintezu pirimidina nizvodno od  DHODH i potiče diferencijaciju aktivacijom kinaze Chk1 i signalnoga puta oštećenja DNK, a isti se put aktivira i tijekom diferencijacije potaknute citarabinom, uobičajenim citotoksičnom lijekom.Različiti čimbenici in vivo doprinose izostanku translacije pretkliničkih otkrića u uspješno kliničko liječenje, kao što su učinci mikrookoliša KS, relaps bolesti i manjak prediktivnih molekularnih markera u oboljelih. U ovome projektu planiramo odrediti učinke strome KS na diferencijaciju AML, odrediti poremećaje nukleotida koji potiču put oštećenja DNK te nizvodne ciljeve aktivirane Chk1, uspostaviti model blasta AML ex vivo koji će bolje probirati oboljele koji odgovaraju na diferencirajuće liječenje te sekvencioniranjem uzoraka primarnih blasta odrediti biomarkere osjetljivosti na lijekove. U konačnici, razvit ćemo mišji model koji omogućava testiranje učinaka lijekova in vivo. Ovaj projekt okuplja stručnjake u područjima kliničke i eksperimentalne hematologije kako bi odredili mehanizme diferencijacije AML te razvili modele i alate koji mogu pomoći probiru oboljelih od AML koji odgovaraju na diferencirajuće liječenje. ]]></summary_hr><summary_en><![CDATA[Lack of differentiation is a hallmark of acute myeloid leukemia (AML) making therapy aimed at differentiation a promising strategy. The most successful example of differentiation therapy is all-trans retinoic acid (ATRA)-based treatment of acute promyelocytic leukemia (APL). The recent success of inhibitors of mutated isocitrate dehydrogenase revived interest in differentiation therapy, and dihydroorotate dehydrogenase (DHODH) inhibitors are being actively explored.Our team has a long-standing experience in studying leukemia differentiation. Our recent studies revealed that 5-aminoimidazole-4-carboxamide ribonucleoside (AICAr) induced differentiation of monocytic AML cell lines and a subset of primary blasts isolated from the bone marrow (BM) of AML patients. AICAr inhibits pyrimidine synthesis downstream of DHODH and induces differentiation by activating Chk1 and DNA damage signalling pathway. The same pathway is activated during differentiation induced by cytarabine, a commonly used cytotoxic drug.Several factors in vivo contribute to the failure to translate preclinical findings to a clinically successful strategy, including the role of the BM microenvironment, relapse of the disease and the lack of predictive molecular markers in patients. In this project, we propose to: determine the effects of BM stroma on AML differentiation, identify nucleotide disturbances that activate DNA damage pathway, identify downstream targets of activated Chk1, develop a model of primary AML blasts ex vivo for better screening for differentiation and to determine molecular biomarkers for drug sensitivity using sequencing of primary blasts. Finally, we will develop a mouse model that allows testing the effects of drugs in vivo.This grant brings together experts in the field of clinical and experimental hematology in order to define the mechanisms of AML differentiation and to develop models and tools that could help to identify AML patients who respond to differentiation therapy.]]></summary_en></project><project>
<id>15097</id><title_hr><![CDATA[Virusi vinove loze: potraga za dijelovima slagalice koji nedostaju]]></title_hr><title_en><![CDATA[Grapevine viruses: search for the missing pieces of the puzzle]]></title_en><user_id>21451</user_id><user_firstLast_name>Darko Vončina</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-3103</code><acronim><![CDATA[GRAVIPUZ]]></acronim><duration>28.12.2023 - 27.12.2027</duration><status>U tijeku</status><financ_value>194.241,00 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Agronomski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Agriculture]]></institution_en><team_members_id>20366, 11198, 866314, 866376, 855437, 24128, 869663, </team_members_id><team_members_names><![CDATA[Ivana Tomaz, Darko  Preiner, Rodrigo Almeida, Kristian Stevens, Mladen Poletti Kopešić, meher Alrwahnih, Nina Buljević, ]]></team_members_names><keywords_hr><![CDATA[virusi, detekcija, prijenos, vinova loza, autohtone sorte, klimatske promjene, vodni stres, reakcija biljke, sekvenciranje ]]></keywords_hr><keywords_en><![CDATA[viruses, detection, transmission, grapevine, autochthonous cultivars, climate change, water stress, plant reaction, sequencing]]></keywords_en><summary_hr><![CDATA[Vinogradarstvo u Hrvatskoj ima dugu tradiciju i karakterizira ga 125 autohtonih sorata vinove loze, od kojih je jedna od najznačajnijih &#39;Plavac mali&#39;. Približno 15% stanovnika Hrvatske izravno ili neizravno je povezano s vinogradarstvom. Istovremeno, virusi vinove loze predstavljaju  globalni problem, a strategije kontrole se temelje na preventivnim mjerama. Ipak,  postoji nedostatak spoznaja o alternativnim domaćinima, ponašanju vektora kao i o utjecaju klimatskih promjena na čitav ekosustav. Hrvatske autohtone sorte, posebice one u priobalnim vinogradarskim regijama, su zaražene virusima u visokom postotku, a posebice onima iz skupine uvijenosti lista (uvijenosti lista vinove loze pridruženi virus 3, GLRaV-3) te kompleksa naboranosti drveta. Područje Kaštela (središnja Dalmacija) karakterizira veliki broj autohtonih sorata, ali i vrlo česta zaraza trsova s više od 10 virusa, čime navedeno područje predstavlja idealno prirodno okruženje za istraživanje različitih aspekata virologije vinove loze. Prvi cilj ovog projekta je probir višegodišnjih biljaka kao potencijalnih alternativnih domaćina u vinogradima ili njihovoj okolici te analiza na prisutnost virusa primjenom tehnologije sekvenciranja nanoporama. S obzirom na ograničene podatke o utjecaju virusa, klimatskih promjena i produženih perioda bez padalina  na hrvatske autohtone sorte, drugi je cilj određivanje utjecaja zaraze &#39;Plavca malog&#39; s GLRaV-3 istovremeno izloženog različitim razinama vodnog stresa. Bit će mjereni i analizirani različiti fiziološki parametri, uključujući i kvantifikaciju GLRaV-3. Treći cilj projektnog prijedloga je utjecaj vodnog stresa i zaraze s GLRaV-3 na ponašanje (aktivnost, kretanje, odabir domaćina) lozine štitaste uši (Planococcus ficus) čestog štetnika u vinogradima te vektora GLRaV-3. Rezultati predloženog projekta doprinijet će razvoju novih strategija kontrole te osigurati vrijedne podatke o utjecaju klimatskih promjena i virusne zaraze na proizvodne rezultate &#39;Plavca malog&#39;. ]]></summary_hr><summary_en><![CDATA[Viticulture in Croatia has a long tradition and is characterised by 125 autochthonous grapevine cultivars, of which Plavac mali is one of the most popular. About 15% of Croatian inhabitants are directly or indirectly connected with viticulture. At the same time grapevine viruses are considered a global problem and control strategies are based on preventive measures. Nevertheless, there is a lack of knowledge about alternative hosts, the behaviour of vectors, and the impact of climate change on the entire ecosystem. Croatian autochthonous grapevines, especially in coastal areas, are highly infected with viruses, particularly those of the leafroll (grapevine leafroll-associated virus 3, GLRaV-3) and rugose wood complexes. The Kaštela region (Central Dalmatia) is characterised by various autochthonous cultivars, but also by grapevines frequently infected with more than 10 viruses, which provides an ideal natural platform for studying various aspects of grapevine virology. The first objective of the project is to screen perennial plants as potential alternative hosts in vineyards and surrounding areas for the presence of viruses using nanopore sequencing technology. Since there is very little data on the impact of the viruses on autochthonous cultivars, climate change and prolonged drought periods, the second objective is to determine the impact of GLRaV-3 on Plavac mali exposed to different levels of water stress. Various physiological parameters will be measured and analysed, including quantification of GLRaV-3. The third objective of the proposed project is to determine the effects of water stress and GLRaV-3 on the behavioural patterns (activity, movement, host selection) of vine mealybug (Planococcus ficus), a common pest in vineyards and GLRaV-3 vector. The results of the proposed project will contribute to the development of new control strategies and provide valuable data on the impact of climate change and virus infection on Plavac mali production.]]></summary_en></project><project>
<id>15102</id><title_hr><![CDATA[Sinteza, karakterizacija i in vitro testiranje amfipatskih porfirina za fotodinamičku terapiju melanoma]]></title_hr><title_en><![CDATA[Synthesis, characterisation and in vitro testing of amphiphilic porphyrins for photodynamic therapy of melanoma]]></title_en><user_id>8722</user_id><user_firstLast_name>Nela Malatesti</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-7000</code><acronim><![CDATA[MELPDT]]></acronim><duration>01.10.2025 - 30.09.2029</duration><status>U tijeku</status><financ_value>199.980,00 eur</financ_value><scie_area_hr>Prirodne znanosti, Biotehničke znanosti, Biomedicina i zdravstvo, </scie_area_hr><scie_area_en>Natural sciences, Biotechnical sciences, Biomedicine and health sciences, </scie_area_en><scie_field_hr>Kemija, Fizika, Biologija, Biotehnologija u biomedicini, </scie_field_hr><scie_field_en>Chemistry, Physics, Biology, Biotechnology in Biomedicine, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Fakultet biotehnologije i razvoja lijekova]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Biotechnology and Drug Development]]></institution_en><team_members_id>376, 1314, 12525, 26353, 2538, 29059, 865009, </team_members_id><team_members_names><![CDATA[Nikola Basaric, Martin Lončarić, Ivana Ratkaj, Martina Mušković, Andrea Dekanić, Nika Hlaca, Maja Juković, ]]></team_members_names><keywords_hr><![CDATA[Porfirin, sinteza, fotosenzibilizator, tripletno pobuđeno stanje, singletni kisik, melanom, tumorski mikrookoliš]]></keywords_hr><keywords_en><![CDATA[Porphyrin, synthesis, photosensitiser, triplet excited state, singlet oxygen, melanoma, tumour microenvironment]]></keywords_en><summary_hr><![CDATA[Fotodinamička terapija (PDT) je sve uspješniji pristup u borbi protiv raka, osobito onih koji su lako dostupni osvjetljavanju, kao što su karcinomi kože, izuzev melanoma. U PDT-u se neškodljiva crvena svjetlost koristi za pobuđivanje molekule fotosenzibilizatora (PS) što dovodi do stvaranja citotoksičnog singletnog kisika i ostalih reaktivnih kisikovih vrsta (ROS). Manja uspješnost PDT-a kod melanoma u odnosu na ostale karcinome kože dovodi se u vezu s melaninom koji značajno apsorbira svjetlo koje se koristi za fotoaktivaciju PS-a, te s hipoksičnim mikrookolišem koji se smatra glavnim razlogom razvoja tumorske rezistencije na lijekove i brzo metastaziranje primarnog tumora. Poznato je da hipoksija ima učinak i na ne-tumorske stanice u tumorskom mikrookolišu (TME), međutim taj je učinak nedovoljno istražen.U našem dosadašnjem istraživanju pokazali smo značajan PDT učinak amfipatskih piridilporfirina na više vrsta stanica raka. Također smo pokazali jači protutumorski učinak u PDT-u piridilporfirina koji su imali dugački alkilni lanac, dakle lipofilniju strukturu, u odnosu na hidrofilne analoge. Cilj našeg novog istraživanja je proširiti i optimizirati sintezu, i razviti metodologiju (foto)fizikalno-kemijske karakterizacije PS-a, te ispitati in vitro PDT učinak PS-a na stanice melanoma, u uvjetima sa i bez pojačane hipoksije, te ispitati učinak na TME. Na temelju istraživanja u prvom dijelu projekta, razvijat će se i sintetizirati strukture PS-a s optimiziranom lipofilnošću i odgovarajućim optičkim svojstvima kako bi se omogućio efikasan ulazak u stanice, ciljanje određenih organela i povećala produkcija ROS-a u PDT-u, te će se testirati njihov učinak na stanice melanoma, kao i povezanost ovih učinaka s promjenama u TME. Također ćemo istražiti i kombinirani učinak sa 2 PS-a s različitim mehanizmima u PDT-u. Konačan cilj istraživanja je doprinos razumijevanju mehanizama PDT-a, te razvoj novih PS-a većeg PDT učinka.]]></summary_hr><summary_en><![CDATA[Photodynamic therapy (PDT) is an increasingly successful approach against cancer, especially those types that are accessible to the photoactivation such as skin cancer, except for melanoma. In PDT, a non-harmful red light is used to activate photosensitiser (PS) molecule that leads to the formation of cytotoxic singlet oxygen and other reactive oxygen species (ROS). Less effective PDT in melanoma, compared to other skin cancers, is associated with melanin that significantly absorbs the light used for photoactivation of the PS, and with a hypoxic microenvironment, which is the major cause of drug resistance development and rapid metastasis of the primary tumour. It is well known that hypoxia influences also non-tumour cells in the tumour microenvironment (TME), but this effect has not been sufficiently investigated.Previously, we have demonstrated a significant PDT effect of amphiphilic pyridylporphyrins on several types of cancer cells. We showed a stronger effect with pyridylporphyrins having a long alkyl chain, relative to their chain-free analogues. The aim of our new research is to extend and optimize the synthesis, and develop methodology for (photo)physicochemical characterization of PSs, and to investigate the in vitro PDT effect of PSs on melanoma cells, under conditions with and without enhanced hypoxia, and the effect on TME. Based on the research in the first part of the project, PS structures with optimized lipophilicity and appropriate optical properties will be developed and synthesized to ensure efficient cell entry, specific organelle targeting, and increase ROS production in PDT, and to evaluate their effect on melanoma cells, as well as the relationship of these effects with changes in TME. We will also investigate the combined effect of two PSs with different mechanisms in PDT. The ultimate goal is to contribute to the understanding of the mechanisms of PDT, and to develop new PSs of greater PDT effect.]]></summary_en></project><project>
<id>15106</id><title_hr><![CDATA[Genetic diagnosis of kidney and urinary tract malformations]]></title_hr><title_en><![CDATA[Genetska dijagnostika malformacija bubrega i mokraćnog sustava]]></title_en><user_id>12479</user_id><user_firstLast_name>Katarina Vukojević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-8720</code><acronim><![CDATA[NEPHROGEN]]></acronim><duration>31.12.2023 - 30.12.2027</duration><status>U tijeku</status><financ_value>199.084,21 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Kliničke medicinske znanosti, Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Clinical sciences, Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Split School of Medicine]]></institution_en><team_members_id>4348, 19253, 19332, 4839, 865780, 19308, 1192, 19588, 4338, 262, 26545, 11243, 19279, 865880, 19276, 11190, 19378, 12795, 25216, 869824, 865059, 856258, 871144, 871142, 872937, </team_members_id><team_members_names><![CDATA[Natalija Filipović, Fila Raguž, Boris Kablar, Merica Glavina Durdov, Nasrollah Ghahramani, Mirna Saraga-Babić, Ivana  Bočina, Vlatka Martinović, Sandra Kostić, Bernarda Lozić, Adela Arapović, Sandra  Zekić Tomaš, Violeta Šoljić, Ana Dunatov Huljev, Nenad Kunac, Ivana Kuzmić Prusac, Simone Sanna-Cherchi, Marijan Saraga, Anita Racetin, Patricija Bajt, Nikola Pavlović, Nela Kelam, Ana Simičić Majce, Marica Maretić, Tomislav Rakić, ]]></team_members_names><keywords_hr><![CDATA[CAKUT, bubreg, genetika, razvoj, WES]]></keywords_hr><keywords_en><![CDATA[CAKUT, kidney, genetics, development, WES]]></keywords_en><summary_hr><![CDATA[Malformacije bubrega i mokraćnog sustava uključuju različite anatomske fenotipove, kao što su agenezija/displazija bubrega, hipoplazija, opstrukcija ureteropelvičnog spoja, vezikoureteralni refluks ili duplicirani ureter i opisani su pod akronimom CAKUT (kongenitalne anomalije bubrega i urinarnog trakta). Ove se malformacije javljaju u polovici pedijatrijskih i 7% odraslih osoba s krajnjim stadijem zatajenja bubrega diljem svijeta i imaju značajan utjecaj na dugoročno preživljenje pacijenata. Genetski čimbenici igraju ključnu ulogu u razvoju CAKUT-a. Međutim, stopa sporadičnih slučajeva koji se objašnjavaju visoko penetrantnim mutacijama u jednom genu možda je bila precijenjena tijekom godina i genetska dijagnoza je u većini slučajeva propuštena. Oko 20% pacijenata može imati genetski poremećaj koji se ne otkriva standardnim kliničkim pregledima, što implicira druge različite mutacijske mehanizme i patogentske putove. Do 15% slučajeva CAKUT-a ima genetski poremećaj za koji se sumnja da uzrokuje neurokognitivno oštećenje i čije rano prepoznavanje može utjecati na kliničku skrb. Uz to, malformacije bubrega i mokraćnog sustava često su prva klinička manifestacija složene sistemske bolesti, stoga rana molekularna dijagnoza može pomoći liječniku da identificira druge subkliničke manifestacije. Fenotipska i etiološka heterogenost CAKUT-a predstavlja značajnu prepreku kliničkom i temeljnom ispitivanju. Stoga je glavni imperativ dobiti uvid u identificiranje novih genetskih pristupa koji mogu pomoći u razotkrivanju genetske arhitekture i primarnih molekularnih defekata koji leže u pozadini CAKUT-a, kako bi se omogućila ispravna dijagnoza, utvrdila prognoza i na kraju razvili učinkoviti modaliteti prevencije i liječenja. Očekuje se da će ovaj projekt identificirati nove gene koji predisponiraju malformacije bubrega i mokraćnog sustava korištenjem visokoučinkovitih genomskih tehnologija kako bi se provela identifikacija gena i početna funkcionalna karakterizacija.]]></summary_hr><summary_en><![CDATA[Kidney and urinary system malformations include different descriptive anatomic phenotypes, such as kidney agenesis/dysplasia, hypoplasia, ureteropelvic junction obstruction, vesicoureteral reflux or duplicated ureter and are described under acronim CAKUT (congenital anomalies of kidneys and urinary tract) (1, 2). These malformations occur in 40-50% of pediatric and 7% of adult end-stage kidney failure worldwide, and they have significant impact on long-term patient survival (1-3). Genetic factors play a key role in the development of kidney and urinary system malformations (4). However, the rate of sporadic CAKUT cases explained by highly penetrant mutations in a single gene may have been overestimated over the years and a genetic diagnosis is missed in most cases (2). Additionally, approximately 20% of patients may have a genetic disorder that is not detected with standard clinical examinations, implying other different mutational mechanisms and pathogenic pathways (3). In particular, up to 15% of CAKUT cases have an unsuspected genomic disorder causing neurocognitive impairment and whose early recognition can impact clinical care (3). Therefore, the importance of identifying new genetic approaches that can help unraveling the genetical architecture of unexplained CAKUT cases is imperative. Additionally, kidney and urinary system malformations are often the first clinical manifestation of a complex systemic disease, therefore, an early molecular diagnosis can help the physician to identify other subclinical manifestations and provide better treatment of patients. ]]></summary_en></project><project>
<id>15108</id><title_hr><![CDATA[Međustanična komunikacija u dijabetičkoj bolesti bubrega]]></title_hr><title_en><![CDATA[Intercellular communication in diabetic kidney disease]]></title_en><user_id>4348</user_id><user_firstLast_name>Natalija Filipović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-7321</code><acronim><![CDATA[RENEX]]></acronim><duration>31.12.2023 - 30.12.2027</duration><status>U tijeku</status><financ_value>197.756,99 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Split School of Medicine]]></institution_en><team_members_id>12479, 19332, 19308, 53, 1192, 4839, 12573, 26025, 809, 1202, 5700, 13069, 869732, 872892, 874059, </team_members_id><team_members_names><![CDATA[Katarina Vukojević, Boris Kablar, Mirna Saraga-Babić, Anita Markotić, Ivana  Bočina, Merica Glavina Durdov, Benjamin Benzon, Nives Kević, Nikolina Režić Mužinić, Angela Mastelić, Ivo Jeličić, Ivana Restović, Marinela Jelinčić Korčulanin, Karla Svaguša, Leo Jercic, ]]></team_members_names><keywords_hr><![CDATA[Dijabetička bolest bubrega, koneksini, paneksini, tijesni spojevi, endotel, podociti, epitel tubula]]></keywords_hr><keywords_en><![CDATA[Diabetic kidney disease, connexins, pannexins, gap-junctions, endothelium, podocytes, tubular epithelium]]></keywords_en><summary_hr><![CDATA[Dijabetička bolest bubrega (DBB) je jedna od najozbiljnijih mikrovaskularnih komplikacija šećerne bolesti, koja postaje vodeći uzrok završnog stadija kronične bubrežne bolesti širom svijeta. Unatoč opsežnim studijama, patofiziološki mehanizmi DBB nisu još u potpunosti razjašnjeni, a postojeći terapijski pristupi nisu učinkoviti u svim slučajevima i/ili je njihova primjena povezana s ozbiljnim nuspojavama. Sve veći broj recentnih studija ukazuje na ulogu izravne međustanične komunikacije i parakrine ATP signalizacije u patofiziologiji DBB, pri čemu glavnu ulogu imaju kanali formirani od koneksina i paneksina. Blokatori koneksinskih i paneksinskih kanala sve se više istražuju kao učinkovita terapijska strategija za inhibiciju sterilne upale u različitim patološkim stanjima, a mogli bi se pokazati uspješnom strategijom za prevenciju ili liječenje DBB. Međutim, uloga koneksinskih i paneksinskih kanala u specifičnim populacijama stanica bubrega još je daleko od potpunog razumijevanja. Cilj je predloženih istraživanja rasvijetliti detaljno ulogu koneksina i paneksina u međustaničnoj komunikaciji različitih tipova stanica tijekom razvoja DBB. Ove ciljeve planiramo ostvariti kombiniranjem više istraživačkih pristupa: detaljnom analizom izražaja koneksina/paneksina u uzorcima tkiva pacijenata oboljelih od šećerne bolesti,   analizom transkriptoma pojedinih populacija stanica bubrega (podociti, epitelne stanice tubula, endotelne stanice) miševa s farmakološki izazvanom šećernom bolešću  te korištenjem animalnih modela miševa kojima je selektivno isključen izražaj koneksina/paneksina u određenim staničnim populacijama bubrega. Rezultati ovih istraživanja pružit će nam bolje razumijevanje uloge koneksina/paneksina u patogenezi DBB, a njihovo poznavanje osnovni je preduvjet za svrsishodnu i efikasnu upotrebu modulacije koneksinskih i paneksinskih kanala kao terapijskog cilja u prevenciji i liječenju DBB, kao i procjenu mogućih štetnih učinaka (primjerice nefrotoksičnosti). ]]></summary_hr><summary_en><![CDATA[Diabetic kidney disease (DKD) is one of the most serious microvascular complications of diabetes, becoming the most common cause of end-stage renal disease worldwide. Despite extensive studies, the pathophysiological mechanisms of DKD are not fully understood, and existing therapeutic approaches are not effective in all cases and/or their use is associated with severe side effects. A growing number of recent studies point to the role of direct intercellular communication and paracrine ATP signaling in the pathophysiology of DKD, with channels formed by connexins and pannexins playing the main role. Blockers of connexin and pannexin channels are increasingly being investigated as an effective therapeutic strategy to inhibit sterile inflammation in various pathological conditions and may prove to be a successful strategy to prevent or treat DKD. However, the role of connexin and pannexin channels in specific renal cell populations is far from fully understood. The aim of this research project is to elucidate in detail the role of connexins and pannexins in the intercellular communication of different cell types during DKD development. We plan to achieve these goals by combining several research approaches: detailed analysis of connexin/pannexin expression in tissue samples from patients with diabetes, transcriptome analysis of individual kidney cell populations (podocytes, tubule epithelial cells, endothelial cells) from mice with pharmacologically induced diabetes, and the use of animal models in which connexin/pannexin expression is selectively silenced in specific kidney cell populations. The results of these studies will provide us with a better understanding of the role of connexin/pannexin in the pathogenesis of DKD, as a prerequisite for the targeted and efficient use of modulation of connexin and pannexin channels as a therapeutic target in the prevention and treatment of DKD, as well as for the evaluation of potential adverse effects (eg, nephrotoxicity).]]></summary_en></project><project>
<id>15112</id><title_hr><![CDATA[Astronomija gama-zraka visokih energija u doba višečestičnih opažanja]]></title_hr><title_en><![CDATA[Very-high-energy Gamma Ray Astronomy in the Multi-messenger Era]]></title_en><user_id>25065</user_id><user_firstLast_name>Marina Manganaro</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-4595</code><acronim><![CDATA[ASTRO-GAMMA]]></acronim><duration>18.12.2023 - 17.12.2027</duration><status>U tijeku</status><financ_value>194.844,69 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Fakultet za fiziku]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Physics]]></institution_en><team_members_id>3127, 3652, 19301, 6374, 865507, 26590, 865945, 19423, 26588, 5738, 865886, 19815, 865937, 865616, 868117, 871155, 873072, </team_members_id><team_members_names><![CDATA[Dario Hrupec, Ana Babic, Tomislav Terzić, Nikola Godinović, Filip Reščić, Jelena Strišković, Michele Doro, Dijana Dominis Prester, Mario Pecimotika, Zeljka Bosnjak, Jasmina Isaković, Saša Mićanović, Toni Šarić, Karlo Mrakovčić, Petra Maruševec, Lorena Lulić, Josiah Olumuyiwa FANIYI, ]]></team_members_names><keywords_hr><![CDATA[Astronomija, Astrofizika, Visoka energija, Gama-zrake, Astronomija ija s više valnih duljina, Čerenkovljevi teleskopi, Astrofizika čestica, Kvantna gr]]></keywords_hr><keywords_en><![CDATA[Astronomy, Astrophysics, High Energy, Gamma-rays, Multi-messenger astronomy, Multi-wavelength astronomy, Cherenkov telescopes, Astroparticle physics, ]]></keywords_en><summary_hr><![CDATA[Nedavno otkriće neutrina emitiranih iz blazara, aktivne galaktičke jezgre za koju znamo da emitira fotone u cijelom elektromagnetskom spektru do najviših energija, jedan je od ključnih događaja koji potvrđuje početak višeglasničke ere u astrofizici. Važan dio te slike je gama-astronomija, područje koja istražuje fotone na najvišim energijama, proizvedene u najnasilnijim procesima u svemiru. S našim prijedlogom želimo ne samo konsolidirati istraživanja gama-astronomije koja se provode u međunarodnoj suradnji kao što su MAGIC (Major Atmospheric Gamma-ray Cherenkov telescopes) i CTA (Cherenkov Telescope Array), već i proširiti hrvatski doprinos ovom području prema teorijskoj interpretaciji rezultata u kontekstu višeglasničke astronomije. To znači da će, uz potvrđeno iskustvo koje proizlazi iz dugogodišnjih znanstvenih rezultata u grani gama-astronomije, naša grupa također raditi na teorijskoj interpretaciji i modeliranju rezultata u širokopojasnom prikazu te na istraživanju učinaka kvantne gravitacije, kao što je narušenje Lorentzove invarijantnosti (LIV). Ovo širenje vidika je pravodobno jer je razumijevanje teorijskih modela ključ za otkrivanje procesa emisije različitih izvangalaktičkih i galaktičkih izvora, uključujući i one najnovije otkrivene na najvišim energijama, nazvane PeVatroni. Kako bismo istražili ta nova energijska područja, radit ćemo na razvoju novog Čerenkovljevog detektora za novu stratešku suradnju sa SWGO (Southern Wide-field Gamma-Ray Observatory).]]></summary_hr><summary_en><![CDATA[The recent discovery of a neutrino emitted by a blazar, an active galactic nucleus known to emit photons across the entire electromagnetic spectrum up to the highest energies, has been one of the key events confirming that we are witnessing a multi-messenger era in astrophysics. Gamma-ray astronomy is an important part of this picture, being the discipline that studies photons at the highest energies, produced in the most violent processes in the Universe. With our proposal we aim to consolidate the gamma-ray astronomy research conducted in international collaborations as MAGIC (Major Atmospheric Gamma-ray Cherenkov telescopes) and CTA (Cherenkov Telescope Array), and moreover to widen the Croatian-based contribution to this field moving towards the theoretical interpretation of the results in a multi-messenger context. This means that, on top of  the proven experience coming from years of scientific results in the field of gamma-ray astronomy, the team will also work on the theoretical interpretation and modelling of the results in a broadband view and on the investigation of quantum gravity effects such as Lorentz Invariance Violation. This expansion of horizons is timely since the understanding of the theoretical models is the key to unveil  the emission process of different extragalactic and galactic sources, including the newest ones discovered at the highest energies, the so-called PeVatron sources. To explore such new energy frontiers we will also work in the development of a novel Cherenkov detector for the new strategic collaboration with the SWGO (Southern Wide-field Gamma-Ray Observatory).]]></summary_en></project><project>
<id>15113</id><title_hr><![CDATA[Terra nullius - na granici i iza granice od 8. do 12. st.]]></title_hr><title_en><![CDATA[Terra nullius - on the border and behind the border from the 8th to the 12th century]]></title_en><user_id>6829</user_id><user_firstLast_name>Krešimir Filipec</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-9121</code><acronim><![CDATA[TerraNullbord]]></acronim><duration>29.12.2023 - 28.12.2027</duration><status>U tijeku</status><financ_value>119.446,99 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Arheologija, Povijest, Etnologija i antropologija, </scie_field_hr><scie_field_en>Archeology, History, Ethnology and anthropology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>12960, 12961, 865986, 865923, 865900, 866007, 5525, 12780, 25583, 4007, 865711, 873195, </team_members_id><team_members_names><![CDATA[Zdravka Hincak, Ana Azinović Bebek, Andrej Magdič, Zrinka Mileusnić, Edin Bujak, Jasmina Davidović, Jana Škrgulja, Petra Nikšić, Ana Kuveždić Divjak, Mirela Pavić Vulinović, Manuela Filipec, Lovro Vragolović, ]]></team_members_names><keywords_hr><![CDATA[Slaveni, Avari, Karolinzi, granice, granična područja, Donja Panonija, Siscia, Lobor, Poetovio]]></keywords_hr><keywords_en><![CDATA[Slavs, Avars, Carolingians, borders, border areas, Lower Pannonia, Siscia, Lobor, Poetovio]]></keywords_en><summary_hr><![CDATA[Projekt Terra nullius – na granici i iza granice od 8. do 12. stoljeća obuhvaća teritorij omeđen Podravinom na sjeveru i Posavinom na jugu, a predstavlja kronološki nastavak i proširivanje dosadašnjih projekata predlagatelja prof. dr. sc. Krešimira Filipca. Navedeni je prostor, u povijesnoj literaturi, opisivan kao Panonska Hrvatska, u ranom srednjem vijeku često se pripisivao različitim gospodarima, a ponekad se opisuje i kao ničija zemlja, odnosno terra nullius. Terra nullius je pravni izraz koji se odnosi na „teritorij bez gospodara“. Čini se da se na toj „ničijoj zemlji“, početkom 10. stoljeća geopolitička tvorevina bliska državi. Život na granici i iza granice na toj „ničijoj“ zemlji (terra nullius) od 8. do 12. st. između jakih, velikih i snažnih sila tema je koja u arheološkoj literaturi nije često obrađivana te mnogi problemi ne samo da nisu riješeni već nisu niti otvoreni. U pomanjkanju drugih dostupnih izvora, groblja su nam često jedini pokazatelj veza i odnosa u ranom srednjem vijeku. Tu se može pratiti protok predmeta koji često upućuje na različite veze i suodnose, a položaj groblja u prostoru, npr. u odnosu na crkvu svjedoči o tome je li riječ o organiziranom području s gospodarom koji prati tadašnje procese ili ne. Smještaj groblja uz crkvu općenito se povezuje uz vrijeme kada postoji jača politička organizacija koja može ljude primorati da svoja stara groblja premjeste tamo gdje im je zadano. Cilj projekta razotkriti je neistražena pitanja navedenog područja, kako bi istraživanje upotpunilo znanstveno istraživanje prostora hrvatskog dijela Panonije u ranom srednjem vijeku.]]></summary_hr><summary_en><![CDATA[The project Terra nullius - on the border and beyond the border from the 8th to the 12th century covers the territory between Podravina in the north and Posavina in the south, and represents a chronological continuation and expansion of the previous projects by the applicant Prof. Krešimir Filipec. In the historical literature, the mentioned area was described as Pannonian Croatia, in the early Middle Ages it was often attributed to different lords, and sometimes it was described as no man&#39;s land, i.e. terra nullius. Terra nullius is a legal term referring to a „territory without a master“. It seems that in this „no man&#39;s land“, at the beginning of the 10th century, a geopolitical creation close to a state was formed. Life on the border and behind the border in that „no man&#39;s land“ (terra nullius) from the 8th to the 12th century between strong, great and powerful forces is a topic that is not often discussed in the archaeological literature, and many problems not only have not been solved but have not been even opened. In the absence of other available sources, cemeteries are often our only indication of connections and relationships in the early Middle Ages. There the flow of objects can be followed, which often points to different connections and correlations, and the position of the cemetery in landscape, for example in relation to the church, testifies to whether or not it was an organized area with a lord who followed the processes of the time. Placing a cemetery next to a church is generally associated with a time when there is a strong political organization that can force people to move their old cemeteries to their designated locations. The aim of the project is to expose the unexplored questions of the mentioned area, in order to complete the scientific research of the Croatian part of Pannonia in the early Middle Ages.]]></summary_en></project><project>
<id>15114</id><title_hr><![CDATA[Metafilozofija]]></title_hr><title_en><![CDATA[Metaphilosophy]]></title_en><user_id>6140</user_id><user_firstLast_name>Boran Berčić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-2550</code><acronim><![CDATA[MetPhil]]></acronim><duration>20.12.2023 - 19.12.2027</duration><status>U tijeku</status><financ_value>103.034,18 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filozofija, </scie_field_hr><scie_field_en>Philosophy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Filozofski fakultet u Rijeci]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>242, 866038, 29675, 3485, 6425, 866198, 866067, 26521, 873001, </team_members_id><team_members_names><![CDATA[Filip Grgić, Justin Weinberg, Andrej Jandrić, Ljudevit Hanžek, Filip Čeč, Timothy Williamson, Mark Balaguer, Vito Balorda, Matija Rajter, ]]></team_members_names><keywords_hr><![CDATA[Filozofija, metafilozofija, metodologija, pojmovna analiza, zaključak na najbolje objašnjenje, refleksija, opravdanje]]></keywords_hr><keywords_en><![CDATA[Philosophy, metaphilosophy, methodology, conceptual analysis, inference to the best explanation, reflection, justification]]></keywords_en><summary_hr><![CDATA[U okviru ovog projekta nastojat ćemo odgovoriti na pitanje Što je filozofija?Raspravit ćemo najčešća gledišta i pokušati utvrditi jesu li održiva. To su: (1) Filozofska pitanja su ona za koja josˇ nije utvrđena standardna metodologija rjesˇavanja. (2) Filozofija je znanost, razlika je u stupnju općenitosti ali ne u vrsti. (3) Sinopticˇko gledište prema kojem je posao filozofije stvaranje sveobuhvatne slike svijeta. (4) Filozofija je njena povijest. (5) Filozofija je pojmovna analiza. (6) Filozofija je refleksija o načinu na koji opravdavamo svoja vjerovanja i djelovanja.Analizirat ćemo poznate i/ili tipične filozofske argumente i nastojati pokazati kojem od ovih shvaćanja odgovaraju. Na primjer, pitanje je kako shvatiti poznati Platonov One Over Many argument za postojanje univerzalija. Je li on izložen kao zaključak na najbolje objašnjenje (gledište 2), kao pojmovno pojašnjenje (gledište 5), ili kao opravdanje vjerovanja (opcija 6)? Ovakvu analizu primjenit ćemo i na druge poznate i tipične filozofske argumente: Mooreov test izolacije za utvrđivanje intrinzičnog dobra, McTaggartov argument da vrijeme nije realno, Mackiev argument from queerness da moralna svojstva ne postoje, Benacerrafov argument protiv platonizma u matematici, Blackov misaoni eksperiment s dvije kugle kojim nastoji oboriti Leibnizov zakon, itd.Iako je većina suvremenih autora sklona opciji (5), fokus će biti na opcijama (2) i (6) jer smatramo da one najviše obećavaju. Jasno, pitanje je što će pokazati detaljna analiza i pitanje je postoji li uopće jedinstveni odgovor na pitanje Što je filozofija?]]></summary_hr><summary_en><![CDATA[In this project we will try to answer the question What is Philosophy? We will discuss the most common views and try to estimate whether they are tenable. (1) Philosophical questions are those that do not yet have standard methodology. (2) Philosophy is science, the difference between the two is a matter of degree, not of kind. (3) Synoptic view - the goal of philosophy is to create an all-encompassing picture of the world. (4) Philosophy is its history. (5) Philosophy is conceptual analysis. (6) Philosophy is a reflection about the way in which we justify our beliefs and actions.We will analyze well known and typical philosophical arguments and try to show to which understanding of philosophy they fit best. For example, how to understand the well-known Plato&#39;s One over Many argument for the existence of the universals? Is it put forward as an inference to the best explanation (view 2), as a conceptual clarification (view 5), or as a justification of belief (view 6)? This kind of analysis we will apply to other well-known philosophical arguments: Moore&#39;s test of isolation for determining whether a value is intrinsic, McTaggart&#39;s argument that time is not real, Mackie&#39;s argument from queerness against the existence of moral properties, Benacerraf&#39;s argument against Platonism in mathematics, Black&#39;s thought experiment with two balls aimed at refuting Leibniz&#39;s Law, etc.Although most contemporary authors favor the view of Philosophy as conceptual analysis (5), the focus will be on the views (2) and (6) because we believe that they are the most promising ones. Of course, the question is what will the detailed analysis show, and whether there is a single answer to the question What is Philosophy?]]></summary_en></project><project>
<id>15116</id><title_hr><![CDATA[Utjecaj prehrane na učinak intranazalnog inzulina na kogniciju u štakorskoga modela sporadične Alzheimerove bolesti]]></title_hr><title_en><![CDATA[Diet-dependent effect of intranasal insulin on cognition in a rat model of sporadic Alzheimer disease]]></title_en><user_id>1191</user_id><user_firstLast_name>Ana Knezović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-1895</code><acronim><![CDATA[AD-INdiet]]></acronim><duration>18.12.2023 - 17.12.2027</duration><status>U tijeku</status><financ_value>192.182,61 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>3079, 22452, 27148, 861481, 866393, 869765, 1198, 872898, </team_members_id><team_members_names><![CDATA[Jelena Osmanović Barilar, Ana Babić Perhoč, Jan Homolak, Davor Virag, Eugenio Barone, Antonia Krsnik, Melita Šalković-Petrišić, Luka Mihalic, ]]></team_members_names><keywords_hr><![CDATA[Alzheimerova bolest, intranazalni inzulin, kognicija, prehrana bogata mastima, inzulinska rezistencija ]]></keywords_hr><keywords_en><![CDATA[Alzheimer&#39;s disease, intranasal insulin, cognition, high-fat diet, insulin resistance ]]></keywords_en><summary_hr><![CDATA[Poremećaj inzulinske signalizacije povezan je s mnogim neurodegenerativnim bolestima, uključujući Alzheimerovu bolest (AD). Smatrano je da su neuroni neovisni o inzulinu, ali nove spoznaje upućuju na ulogu inzulina u metabolizmu glukoze u mozgu. Sve više dokaza pokazuje da su inzulinska rezistencija i metabolička disfunkcija posrednici AD-a, što dodatno karakterizira AD kao središnju metaboličku bolest posredovanu inzulinskom rezistencijom u mozgu (IRBS). Terapijski potencijal intranazalnog (IN) inzulina u liječenju AD-a ispitivan je u kliničkim studijama te je, načelno,  nađeno a kognitivno poboljšanje ali u nekoliko studija IN inzulin nije imaopovoljni učinak, moguće kao posljedica još nejasnih molekularnih mehanizama središnjih učinaka inzulina i njegove distribucije nakon IN primjene. Cilj projekta je istražiti središnju i perifernu distribuciju akutnog IN inzulina ovisno o vremenu i dozi. Nadalje, obzirom da je prehrana jedna od ključnih komponenti u razvoju metaboličkog sindroma (čimbenik rizika za AD), učinci IN inzulina na kogniciju mogli bi ovisiti o prehrani. Streptozotocin (STZ) se koristi u pretkliničkim istraživanjima za induciranje dijabetes mellitusa u životinja nakon periferne primjene visokih doza te za induciranje IRBS i posljedično sporadičnog oblika AD (sAD), intracerebroventrikularnom (icv) primjenom malih doza. Dodatno, projekt ima za cilj istražiti utjecaj prehrane na učinak IN inzulina na kogniciju (prehrana s visokim udjelom masti) u STZ-icv modelu sAD-a. Rezultati projekta proširit će znanje o čimbenicima koji utječu na terapijski potencijal IN inzulina, u ovisnosti o stadiju sAD-a i prehrani životinja te pružiti informacije o translaciji rezultata sa životinja na čovjeka i prilagodbi doze inzulina ovisno o metaboličkom statusu pacijenta. Budući da IRBS može biti u pozadini i drugih bolesti, razjašnjenje terapijskog potencijala IN inzulina od velike je važnosti za neurofarmakologiju.]]></summary_hr><summary_en><![CDATA[Impaired response to insulin has been linked to many neurodegenerative disorders including Alzheimer’s disease (AD). Neurons have been considered to be independent of insulin, but emerging evidence suggests that insulin has a role in glucose metabolism in the brain. A growing body of evidence indicates that insulin resistance and metabolic dysfunction are mediators of AD, proposing AD as a central metabolic disease mediated by insulin resistant brain state (IRBS). Therapeutic potential of intranasal (IN) insulin in AD has already been in the focus of many clinical trials, demonstrating, in general, an enhancement of memory performance but in few studies, IN insulin had no beneficial effects, which could be due to yet unclear molecular mechanisms of the central insulin effect and its distribution after IN administration. The project aims to investigate central and peripheral distribution of acutely administered IN insulin in time- and dose-dependent manner. Furthermore, since diet is one of the crucial components in development of metabolic syndrome (risk factor for AD), the effects of IN insulin on cognition could depend on the diet. Streptozotocin (STZ) is wildly used in preclinical research to induce diabetes mellitus in animals when given peripherally in high dose, and to induce IRBS and consequently the sporadic AD (sAD), when given intracerebroventricularly (icv) in small doses. The project also aims to explore the diet-conditioned (high-fat diet) effect of IN insulin on cognition in a STZ-icv rat model of sAD. The project results will enlarge the knowledge on the factors affecting the therapeutic potential of IN insulin, particularly the stage of sAD and animal diet, and provide a valuable information on animal-to-human translation and treatment corrections depending on patient metabolic status. Since IRBS may underlay diseases other than AD, elucidation of the therapeutic potential of IN insulin is of great importance for modern neuropharmacology.]]></summary_en></project><project>
<id>15117</id><title_hr><![CDATA[Uloga adiponektina u biologiji memorijskih CD8 T stanica]]></title_hr><title_en><![CDATA[The Role of Adiponectin in Memory CD8 T cell Biology]]></title_en><user_id>19051</user_id><user_firstLast_name>Felix Wensveen</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-3414</code><acronim><![CDATA[RAMBO]]></acronim><duration>18.12.2023 - 17.12.2027</duration><status>U tijeku</status><financ_value>199.083,18 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, Clinical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Medicine]]></institution_en><team_members_id>25630, 19737, 19638, 29106, 869760, 873092, </team_members_id><team_members_names><![CDATA[Mia Krapić, Marko Šestan, Tamara Turk Wensveen, Dora Gašparini, Ozren Majstorović, Sanja Skok, ]]></team_members_names><keywords_hr><![CDATA[Adiponektin, memorijske stanice CD8 T, dijabetes melitus tip 2, virusna infekcija, metabolizam, imunitet]]></keywords_hr><keywords_en><![CDATA[Adiponectin, memory CD8 T cells, diabetes mellitus type 2, viral infection, metabolism, immunity]]></keywords_en><summary_hr><![CDATA[Imunosni i endokrini sustav zamršeno su povezani. Imunosni sustav pokreće metaboličke promjene kao odgovor na infekciju, koje se u našem tijelu prepoznaju kao simptomi bolesti. Na taj način kao i podešavanjem endokrine signalizacije, imunosni sustav doprinosi boljoj borbi protiv infekcije. S druge strane, i endokrini hormoni imaju snažan utjecaj na imunološke stanice čime se osigurava da se njihova potrošnja prilagodi sustavnoj dostupnosti. Međutim, većina imunomodulatornih učinaka hormona još uvijek nije dovoljno istražena. Nove spoznaje u tom prodručju su od naročite važnosti za pacijente s metaboličkim bolestima poput dijabetesa tipa 2 (T2D), koji imaju poremećaj u radu endokrinog sustavaa, a uz to su i osjetljiviji na infekcije. Limfociti CD8 T izražavaju vrlo visoku razinu receptora za endokrini hormon adiponektin. Ovaj hormon potječe iz masnog tkiva, a naši preliminarni podaci ukazuju na to da potiče stvaranje memorijskih stanica. U ovom projektu istražit ćemo specifičan učinak adiponektina na memorijske limfocite CD8 T te odgovoriti na pitanje igra li ulogu u poremećaju funkcije imunoloških stanica u kontekstu T2D. Korištenjem već uspostavljenih in vitro i in vivo modela te genetski modificiranih miševa odredit ćemo specifičnu ulogu ovog hormona u memorijskim stanicama. Kombinacijom napredne proteomike, transkriptomike i metabolomike razjasnit ćemo molekularne mehanizme putem kojih ovaj faktor utječe na memorijske stanice. S već uspostavljenim mišjim modelima za metaboličke bolesti odredit ćemo specifičnu ulogu adiponektina u poremećaju funkcije memorijskih limfocita CD8 T u kontekstu T2D. Konačno, analizom stanica zdravih ljudskih dobrovoljaca, kao i pacijenata s T2D-om, potvrdit ćemo važnost naših nalaza za ljude. Ukratko, naš projekt će dodatno pojasniti imunološko-endokrine interakcije u zdravlju i u kontekstu metaboličkih bolesti. ]]></summary_hr><summary_en><![CDATA[The immune and endocrine systems are intricately linked. In response to infection the immune system mediates metabolic changes in our body, generally referred to as sickness behavior, by adjusting endocrine signaling, with the purpose to better fight infection. Conversely, endocrine hormones have a profound impact on immune cells to ensure that their consumption is adjusted to the systemic availability. However, much of the immunomodulatory effects of hormones is unknown. This is of particular importance in for patients with metabolic disease such as Type 2 diabetes (T2D), who have endocrine dysregulation and are also more susceptible to infection. CD8 T cells express very high levels of the receptors for the endocrine hormone adiponectin and our preliminary data indicates that this adipose tissue-derived hormone promotes memory cell formation. In this project we will investigate the specific effect of adiponectin on memory CD8 T cells and whether it plays a role in immune cell dysfunction in context of T2D. By using established in vitro and in vivo models in combination with genetically modified mice, we will determine the specific role of this hormone in memory cells. With a combination of advanced proteomics, transcriptomics and metabolomics, we will elucidate the molecular mechanisms via which this factor mediates its effect in memory cells. With our established mouse models for metabolic disease, we will determine the specific role of adiponectin in memory CD8 T cell disfunction in context of T2D. Finally, by analyzing cells from healthy human volunteers, as well as of patients with T2D, we will confirm the relevance of our findings for the human situation. In summary, our project will shed important new light on immune-endocrine interactions in health and in context of metabolic disease. ]]></summary_en></project><project>
<id>15121</id><title_hr><![CDATA[Evlija Čelebi i istočna Hrvatska u 17. stoljeću]]></title_hr><title_en><![CDATA[Evliya Çelebi and Eastern Croatia in the 17th Century]]></title_en><user_id>7174</user_id><user_firstLast_name>Anđelko Vlašić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-8014</code><acronim><![CDATA[EVLIYAECRO]]></acronim><duration>15.12.2023 - 14.12.2027</duration><status>U tijeku</status><financ_value>94.710,99 eur</financ_value><scie_area_hr>Humanističke znanosti, Društvene znanosti, Tehničke znanosti, Interdiciplinarne znanosti, Prirodne znanosti, </scie_area_hr><scie_area_en>Humanities, Social sciences, Technological sciences, Interdisciplinary scientific area, Natural sciences, </scie_area_en><scie_field_hr>Interdisciplinarne humanističke znanosti, Arhitektura i urbanizam, Demografija, Filologija, Povijest, Etnologija i antropologija, </scie_field_hr><scie_field_en>Interdisciplinary humanities, Architecture and Urban Environment, Demography, Philology, History, Ethnology and anthropology, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>931, 865755, 7081, 865784, 783, </team_members_id><team_members_names><![CDATA[Zlatko Karač, Dino Mujadžević, Marta Andrić, Eldina Lovaš, Stanko Andrić, ]]></team_members_names><keywords_hr><![CDATA[povijest, Evlija Čelebi, istočna Hrvatska, 17. stoljeće, Slavonija, Srijem, Baranja]]></keywords_hr><keywords_en><![CDATA[history, Evliya Çelebi, eastern Croatia, 17th century, Slavonia, Syrmia, Baranya]]></keywords_en><summary_hr><![CDATA[Za prostor današnje istočne Hrvatske, odnosno Slavoniju, južnu Baranju i zapadni Srijem, za sredinu 17. stoljeća imamo najmanje izvora, a time i najmanju istraženost. Osobito je velik nedostatak narativnih izvora koji bi nudili detaljnije informacije o stanju pod osmanskom vlašću. Iznimku predstavlja Putopis osmanskog putopisca Evlije Čelebija, koji nam nudi nove spoznaje o etničkoj i konfesionalnoj strukturi istočne Hrvatske, jasniju percepciju razvijenosti tamošnjih naselja i proširenje spoznaja o osmanskoj baštini. Premda je bosanskohercegovački orijentalist Hazim Šabanović tijekom 1950-ih preveo dijelove Putopisa, taj se prijevod temeljio na manjkavoj i nepotpunoj verziji rukopisa. Zato će se projekt usredotočiti na analizu nedavno pronađenog autografa, odnosno izvornog rukopisa Putopisa, budući da dijelovi autografa koji opisuju hrvatske prostore sadrže i 35 % više teksta nego raniji prijevod. Projekt će uključivati interdisciplinarno istraživanje mnogih segmenata Putopisa koji dosad uopće nisu analizirani, uključujući historiografske, filološke i arhitekturne segmente. Samo je jedan dosadašnji projekt HRZZ-a bio fokusiran na istraživanje osmanskog razdoblja hrvatske povijesti. Ovaj projekt će biti prvi koji će se potpuno posvetiti istraživanju povijesti istočne Hrvatske pod osmanskom vlašću. Ciljevi projekta su unaprijediti znanstvene spoznaje o povijesti istočne Hrvatske u 17. stoljeću, omogućiti pristup autografu Putopisa objavljivanjem kritičkog prijevoda i potaknuti razvoj nove generacije mladih istraživača. Zbog regionalnog i interdisciplinarnog fokusa bit će to pionirski pothvat na polju istraživanja najobimnijega osmanskog narativnog izvora za hrvatsku povijest i doprinijet će popunjavanju praznina u znanju o raznim aspektima povijesti istočne Hrvatske u 17. stoljeću. Rezultati istraživanja poslužit će kao poticaj budućim istraživanjima istočne Hrvatske i primjeni istoga metodološkog okvira na istraživanje drugih hrvatskih prostora opisanih u Putopisu.]]></summary_hr><summary_en><![CDATA[For the area of eastern Croatia, i.e. Slavonia, southern Baranja and western Syrmia, we have the fewest historical sources for the middle of the 17th century. There is a particularly great lack of narrative sources that would offer more detailed data about the Ottoman rule in that area. An exception is the Travelogue of the Ottoman traveler Evliya Çelebi, which offers us new data about the ethnic and confessional structure of eastern Croatia, a clearer perception of the development of its settlements, and the scope of its Ottoman heritage. Although orientalist Hazim Šabanović translated parts of the Travelogue during the 1950s, this translation was based on a flawed and incomplete version of the manuscript. That is why this project will focus on the analysis of the recently found autograph, i.e. the original manuscript of the Travelogue, since its parts which describe Croatia contain 35% more text than the earlier translation. The project will include interdisciplinary research of segments of the Travelogue which have not been analyzed so far, e.g. its historiographical, philological and architectural segments. Only one HRZZ project so far was focused on research of the Ottoman period of Croatian history. This project will be the first to fully devote itself to researching the history of eastern Croatia under Ottoman rule. The objectives of the project are to advance knowledge about the 17th-century history of eastern Croatia, provide access to the autograph by publishing an annotated translation, and encourage the development of a new generation of young researchers. Due to its regional and interdisciplinary focus, it will be a pioneering undertaking in the field of research into the most extensive Ottoman narrative source for Croatian history. The results will serve as an incentive for future research into eastern Croatia and the application of the same methodological framework to the research of other Croatian areas described in the Travelogue.]]></summary_en></project><project>
<id>15122</id><title_hr><![CDATA[Priprava, karakterizacija i biokompatibilnost novih supramolekulskih kompleksa lijek/ciklodekstrin i lijek/dekstrinske nanospužve s poboljšanim svojstvima]]></title_hr><title_en><![CDATA[Preparation, characterization and biocompatibility studies of novel drug/cyclodextrin and drug/dextrin-based nanosponge supramolecular complexes with enhanced functionality]]></title_en><user_id>851</user_id><user_firstLast_name>Nives Galić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-6033</code><acronim><![CDATA[DrugCD.com]]></acronim><duration>18.12.2023 - 17.12.2027</duration><status>U tijeku</status><financ_value>193.779,01 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>865687, 865638, 865637, 3915, 3061, 865529, 865523, 19814, 28999, 29025, 865604, 869774, 25302, </team_members_id><team_members_names><![CDATA[Francesco Trotta, Fabrizio Caldera, Adrian Matencio, Mario Jug, Ana Budimir, Ana Čikoš, Marta Hoelm, Marijana Pocrnić, David Klarić, Tatjana Kezele Špehar, Ana Meštrović, Franjo Sakoman, Robert Kerep, ]]></team_members_names><keywords_hr><![CDATA[Lijekovi, ciklodekstrini, nanospužve, supramolekulski kompleksi, topljivost, degradacijski produkti, računalna kemija, NMR, LC-MS, ITC]]></keywords_hr><keywords_en><![CDATA[Drugs, cyclodextrins, nanosponges, supramolecular complexes, solubility, degradation products, computational chemistry, NMR, LC-MS, ITC]]></keywords_en><summary_hr><![CDATA[Glavni cilj projekta je poboljšanje terapijskog potencijala nekih slabo topljivih lijekova za oralnu primjenu kao što su prazikvantel, loratadin, cinarizin, meloksikam, nabumeton, mebendazol i triklabendazol. Kako bi se povećala topljivost u vodi slabo topljivih lijekova, često se pripravljaju inkluzijski kompleksi lijekova i ciklodekstrina (CD). Cilj nam je zadržati aktivnost, a poboljšati topljivost gore navedenih lijekova, uklapanjem u beta-ciklodekstrin, 2-hidroksipropil-beta-ciklodekstrin te sulfobutilirani i metilirani beta-ciklodekstrin, koji se koriste kao biokompatibilni nosači u suvremenim oblicima lijekova. Uz CD, koristit će se i komercijalno nedostupne nanospužve temeljene na maltodekstrinu (MD) i CD. Razvit će se nove polimerne formulacije s optimalnim afinitetom lijeka prema NS, a time će se unaprijediti primjena  dekstrinskih-NS i utrti put njihovim budući inovativnim primjenama. Kompleksni spojevi lijek-CD, lijek-MD i lijek-NS detaljno će se analizirati u otopini i u čvrstom stanju. Tijekom projekta razvit će se nove analitičke metode, a poseban naglasak bit će na sofisticiranim tehnikama kao što su tekućinska kromatografija spregnuta sa spektrometrijom masa visokog razlučivanja (LC-HR MS). Također će se provesti istraživanja kemijske stabilnosti i fotostabilnosti, te će se predložiti strukture razgradnih produkata na temelju NMR i HR MS/MS spektara. Topljivost pripravljenih kompleksa odredit će se u biorelevantnim medijima, te će se ispitati biokompatibilnost pripremljenih kompleksa poboljšanih svojstava. Naposljetku, provest će se ispitivanja in vitro permeabilnosti odabranih supramolekulskih kompleksa. ]]></summary_hr><summary_en><![CDATA[The main goal of this project is to improve therapeutic potential of some poorly soluble drugs which are administered orally, like praziquantel, loratadine, cinnarizine, meloxicam, nabumetone, mebendazole and triclabendazole. Inclusion of drugs in cyclodextrins (CD) is frequently used to increase the dissolution of poorly water-soluble drugs. We aim to improve the solubility of above-mentioned drugs, while maintaining their activity, by encapsulation into beta-cyclodextrin, 2-hydroxypropyl-beta-cyclodextrin, sulfobutylated and methylated beta-cyclodextrin, known as biocompatible drug-carriers in drug-delivery systems. In addition to CD, the dextrin-based nanosponges (NS) will be used as well. Non-commercially available NS based on maltodextrin (MD) and CD will be prepared. The new polymer formulations that will be developed to optimize the drug-NS affinity will push forward the technology of dextrin-NSs, paving the way towards future innovative applications. Drug-CD, drug-MD and drug-NS complexes will be analyzed in detail in solid state and in solution. Within the project new analytical methods will be developed, and special attention will be given to sophisticated techniques such as liquid chromatography-high resolution mass spectrometry (LC-HR MS). Chemical stability testing and forced degradation studies will be performed, and identification and structural characterization of degradation products by NMR and HR MS/MS will be done. The solubility of prepared complexes will be investigated in biorelevant media, and biocompatibility of complexes with enhanced properties will be determined. Finally, in vitro permeability of selected supramolecular complexes will be characterized as well.]]></summary_en></project><project>
<id>15126</id><title_hr><![CDATA[Otkrivanje regulatorne mreže gena za glikozilaciju imunoglobulina G upotrebom molekularnih alata CRISPR/dCas9 ]]></title_hr><title_en><![CDATA[Dissecting regulatory gene network for IgG glycosylation using CRISPR/dCas9 molecular tools ]]></title_en><user_id>5416</user_id><user_firstLast_name>Vlatka Zoldoš</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-1358</code><acronim><![CDATA[IgGeneNET]]></acronim><duration>21.12.2023 - 20.12.2027</duration><status>U tijeku</status><financ_value>197.603,03 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>5468, 26165, 21362, 865802, 5620, 5596, 1017, 25522, 873095, </team_members_id><team_members_names><![CDATA[Marija Klasić, Anika Mijakovac, Goran Josipović, Fran Lukšić, Aleksandar Vojta, Vedrana Vičić Bočkor, Maja Pučić Baković, Jasminka Krištić, Kristina Nikolić, ]]></team_members_names><keywords_hr><![CDATA[regulacija gena, CRISPR/dCas9, epigenetika, IgG glikozilacija, upalne bolesti, GWAS, HEK293 Free Style, limfoblastoična stanična linija]]></keywords_hr><keywords_en><![CDATA[gene regulation, CRISPR/dCas9, epigenetics, IgG glycosylation, inflammatory diseases, GWAS, HEK293 Free Style, LCL cell line]]></keywords_en><summary_hr><![CDATA[U projektu ćemo idntificirati mrežu gena uključenu u regulaciju glikozilacije imunoglobulina G (IgG). Glikani vezani za Fc regiju molekule IgG određuju strukturu i efektorske funkcije antitijela. Galaktozilirani i sijalinizirani glikani vezani na Fc regiju IgGa imaju protuupalni učinak, dok sržna fukoza štiti od štetnog ADCC. Glikozilacija IgG promijenjena je u kroničnim upalnim i autoimunim bolestima i raku, a mijenja se i starenjem. Otprilike 15% IgG antitijela ima glikoziliranu Fab regiju za koju je pokazano da je povezana s gubitkom tolerancije u autoimunim bolestima. Nekoliko cijelogenomskih studija povezanosti  IgG glikoma identificiralo je 29 novih genskih lokusa sa dosad nepoznatom ulogom u glikozilaciji IgG, a koji objašnjavaju oko 22% varijacije i imaju pleiotropan učinak na imunološki sustav i upalu. GWAS studije osnivaju se na in silico analizama, stoga je neophodna funkcionalna validacija kadidat genskih lokusa. U našoj istraživačkoj grupi razvijen je tranzijentni ekspresijski sustav baziran na stanicama FreeStyle™293F koje izlučuju IgG te imaju stabilno ugrađene fuzije VPR-dCas9 i KRAB-dCas9 za manipulaciju gena. Ovaj sustav omogućava manipulaciju gena i analizu glikozilacije IgGa u isto vrijeme. Sustav je validiran, a dobiveni rezultati  objavljeni su u 2 visoko rangirana časopisa u području. Glavni cilj predloženog projekta je razlučivanje kauzalnih odnosa alternativne glikozilacije IgG i upale te ostalih procesa povezanih sa starenjem. Projektom ćemo modificirati tranzijentni ekspresijski sustav HEK-293F u svrhu određivanja IgG Fab i Fc glikozilacije, te ćemo razviti sustav limfoblastoidnih stanicama  s ugrađenim dCas9 fuzijama u svrhu manipulacije istih kandidat gena, GWAS hitova. Integracija i korelacija podataka dobivenih pomoću tri različita sustava omogućiti će identifikaciju mreže gena uključene u regulaciju i alternativnu glikozilaciju IgG povezanu s upalom i ostalim bolestima.]]></summary_hr><summary_en><![CDATA[In this project we will dissect the gene network that regulating immunoglobulin G (IgG) glycosylation. The glycans on IgG  influence structural stability and effector functions of the antibody. Galactosylated and sialylated glycans on IgG Fc region have anti-inflammatory effect, while core fucose acts as a safety switch against harmful ADCC. IgG glycosylation is altered in chronic inflammatory and autoimmune diseases and cancer, as well as in ageing. Approximately 15% of IgG antibodies also have  glycosylated Fab region, which seems to be implicated in the loss of tolerance in autoimmune diseases. Several genome wide associated studies (GWAS) of IgG glycome identified 29 novel gene loci with yet unknown roles in IgG glycosylation that explain up to 22% of variance and are pleiotropic with immune function and inflammation. Since GWAS is a data-driven approach there is a need for functional follow-up of the identified genes. For this purpose we developed an in vitro transient expression system based on FreeStyleTM293-F (HEK-293F) cells secreting IgG, with stably integrated VPR-dCas9 and KRAB-dCas9 fusions for gene manipulations. The system is elegant because it allows gene manipulations and analysis of resulting IgG glycan phenotype in one step. The system is validated and results are published in two highly ranked journals in the field. The main objective of this project is to elucidate a causative relationship between alternative IgG glycosylation and inflammation and other age-related processes. We will modify the HEK-293F transient expression system for analysis of both IgG Fab and Fc glycosylation. Furthermore, we will design system based on lymphoblastoid cells LCL-HD0016 with integrated dCas9-fusions for gene manipulations and glycan analysis in one step. Correlation of the data, generated by the three different systems, will allow dissecting the gene network responsible for regulation and alternative IgG Fc and Fab glycosylation associated with inflammation.]]></summary_en></project><project>
<id>15127</id><title_hr><![CDATA[Održivi pristupi iskorištavanja biopotencijala nusproizvoda bobičastog voća ]]></title_hr><title_en><![CDATA[Sustainable approaches to utilization of the biopotential of berry by-products]]></title_en><user_id>1002</user_id><user_firstLast_name>Ivona Elez Garofulić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-5499</code><acronim><![CDATA[NoWaBerry]]></acronim><duration>29.12.2023 - 28.12.2027</duration><status>U tijeku</status><financ_value>199.084,20 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Prehrambena tehnologija, </scie_field_hr><scie_field_en>Food technology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Food Technology and Biotechnology]]></institution_en><team_members_id>206, 453, 1307, 493, 1062, 1330, 1056, 590, 23617, 23329, 20284, 6435, 12848, 855442, 869710, 25271, 1243, </team_members_id><team_members_names><![CDATA[Zoran Herceg, Jasna Mrvčić, Damir Stanzer, Tomislava Vukušić Pavičić, Sandra Pedisić, Maja Repajić, Zoran Zorić, Višnja Stulić, Karla Hanousek Čiča, Ana Huđek Turković, Sanja Loncaric, Jelena Gadže, Sandra Balbino, Ena Cegledi, Ana Martić, Zdenka Pelaić, Verica Dragović-Uzelac, ]]></team_members_names><keywords_hr><![CDATA[ nusproizvodi bobičastog voća, fenolni spojevi, biološka aktivnost, minimalno procesirano voće, funkcionalni proizvodi, održivost]]></keywords_hr><keywords_en><![CDATA[berry by-products, phenolic compounds, biological activity, minimally processed fruit, functional products, sustainability]]></keywords_en><summary_hr><![CDATA[Nakon prerade crnog ribiza (Ribes nigrum L.), borovnice (Vaccinium myrtillus L.) i aronije (Aronia melanocarpa L.) zaostaju velike količine nusproizvoda (komina, list) (NPBV) koji sadrže značajne udjele fenolnih spojeva (FS)-antocijani, flavonoli, flavanoli, proantocijanidini, koji pojedinačno ili u sinergiji pokazuju antioksidativna, antimikrobna, protuupalna i druga pozitivna djelovanja. Valorizacija NPBV te primjena održivih principa njihovog iskorištavanja još uvijek je nedovoljno istražena, a značajnu ulogu u tom procesu ima selekcija otapala, konvencionalne i napredne tehnike ekstrakcije (NTE) te primjena različitih predtretmana. Stoga je jedan od ciljeva istražiti utjecaj predtretmana poput kriomljevenja, pulsirajućeg električnog polja, ekstrakcije superkritičnim CO2 i mikrobne fermentacije, na učinkovitost ekstrakcije ciljanih FS specifičnog djelovanja. Primjena predtretmana te naročito sinergijskih učinaka predtretmana i NTE bazira se na različitim mehanizmimima djelovanja, koji utječu na razaranje stanične stijenke, povećanju učinkovitosti difuzije FS, što bi trebalo rezultirati većim prinosima FS.Očekuje se da će provedeno istraživanje pridonijeti dubljem razumijevanju korelacije ciljanih skupina FS ekstrakata NPBV i njihovih bioloških djelovanja (s naglaskom na antioksidativno, protuupalno, antiproliferativno i antimikrobno djelovanje) te potencijalne primjene u različitim segmentima prehrambene industrije. Primjerice, ekstrakti s većim udjelom proantocijanidina mogu poslužiti kao baza za proizvodnju prirodnih mikrobiocida, a istraživanjem će se utvrditi efikasnost njihove primjene u produljenju trajnosti minimalno procesiranog bobičastog voća. Za ekstrakte koji pokažu značajno antioksidativno, antiproliferativno i protuupalno djelovanje definirat će se optimalni uvjeti stabilizacije sušenjem raspršivanjem za proizvodnju prahova te će se istražiti mogućnost njihove primjene u razvoju novih formulacija dodataka prehrani i funkcionalnih proizvoda. ]]></summary_hr><summary_en><![CDATA[After the processing of blackcurrant (Ribes nigrum L.), blueberry (Vaccinium myrtillus L.) and chokeberry (Aronia melanocarpa L.), large amounts of by-products (pomace, leaves) (BBP) remain, which contain significant content of phenolic compounds (PC)- anthocyanins, flavonols, flavanols, proanthocyanidins, which individually or in synergy show antioxidant, antimicrobial, anti-inflammatory and other positive effects. The BBP valorization and the application of sustainable principles of their exploitation is still insufficiently explored. Solvent selection, conventional and advanced extraction techniques (AET) and application of various pretreatments play a significant role in this process.Therefore, one of the goals is to test the influence of pretreatments such as cryomilling, pulsed electric field, supercritical CO2 extraction and microbial fermentation, on the extraction efficacy of targeted PC with specific activity. Application of pretreatments and their synergistic effects with AET is based on different mechanisms of action, which affect the cell wall disruption, increasing the efficiency of PC diffusion and result in higher PC yields. This research will contribute to a deeper understanding of the correlation between PC target groups of BBP extracts and their bioactivity (with an emphasis on antioxidant, anti-inflammatory, antiproliferative and antimicrobial activity) and potential application in the food industry. For example, extracts with higher content of proanthocyanidins can serve as basis for the production of natural microbiocides, and research will determine the efficacy of their application in extending the shelf life of minimally processed berries (MPB). For extracts that show significant biological activity, optimal conditions of stabilization by spray drying for the production of powders will be defined, and the possibility of their application in the development of new formulations of dietary supplements and functional products will be explored.]]></summary_en></project><project>
<id>15129</id><title_hr><![CDATA[Razvoj algoritama grupiranja podataka, regresije i izdvajanja značajki s primjenama u patologiji, oftalmologiji i metabolomici]]></title_hr><title_en><![CDATA[Development of algorithms for data clustering, regression and feature extraction with applications in pathology, ophthalmology and metabolomics]]></title_en><user_id>19111</user_id><user_firstLast_name>Ivica Kopriva</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-6403</code><acronim><![CDATA[PHATOME]]></acronim><duration>18.12.2023 - 17.12.2027</duration><status>U tijeku</status><financ_value>135.921,43 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>66, 6982, 19142, 3410, 19360, 25398, 865688, 865781, 19164, </team_members_id><team_members_names><![CDATA[IVANKA JERIC, Damir Seršić, Fei Shi, Marijana  Popović Hadžija, Arijana Pačić, Dario Sitnik, Lovro Sindičić, Irena Veliki Dalić, Xinjian Chen, ]]></team_members_names><keywords_hr><![CDATA[nenadzirano učenje, duboko učenje, grupiranje podataka, robusna regresija, tenzorske reprezentacije, računalna patologija, metabolomika, oftalmologija]]></keywords_hr><keywords_en><![CDATA[unsupervised learning, deep learning, data clustering, robust regression, tensor representations, computational pathology, metabolomics, ophthalmology]]></keywords_en><summary_hr><![CDATA[Predlaže se razvoj: (i) samonadziranih robusnih podatcima prilagođenih algoritama grupiranja velikih skupova podataka generiranih iz (ne)linearnih niskodimenzionalnih potprostora; (ii) algoritama linearne regresije regulariziranih podacima prilagođenim funkcijama rijetkosti (surogatima L0 kvazi-norme); (iii) algoritama za aproksimaciju višedimenzionalnih skupova podataka tenzorskim modelima niskog ranga s primjenama u izdvajanjima diskriminativnih značajki iz tenzorskih podataka. Algoritmi razvijeni pod (i) biti će primijenjeni na semantičku segmentaciju hiperspektralne slike bojanih patohistoloških preparata smrznute sekcije adenokarcinoma debelog crijeva u jetri, te na semantičku segmentaciju RGB slike bojanih patohistoloških preparata tri česta tumora jetre (hepatocelularni karcinom, kolangiocelularni karcinom i adenokarcinom debelog crijeva u jetri). Ovima primjenama se želi vrednovati doprinos hiperspektralnog oslikavanja u kvaliteti segmentacije, odnosno kvaliteta modela za segmentaciju različitih tumora jetre. Algoritmi razvijenih pod (ii) biti će primijenjeni na identifikaciju metabolita prisutnih s malim udjelom u 1H NMR spektrima humanog urina osoba s dijabetesom tipa II koristeći proširenu biblioteku (290 do 330) metabolita indikativnih za humani urin i/ili dijabetesom tipa II. Ova primjena je važna za problem neciljanog metaboličkog profiliranja gdje se želi identificirati što veći broj metabolita u biološkom uzorku. Algoritmi razvijeni pod (ii) i (iii) biti će primijenjeni na dijagnostiku  čestih bolesti retine izdvajanjem diskriminativnih značajki iz 3D slike optičke koherentne tomografije. Ova primjena je važna jer je potencijalna alternativa dubokim mrežama koje su zahtjevne za učenje.]]></summary_hr><summary_en><![CDATA[Project proposes development of: (i) self-supervised data adaptive algorithms for clustering of large datasets generated from (non)linear low-dimensional subspaces; (ii) algorithms for linear regression with data adaptive sparse regularization functions (surrogates of L0 quasi-norm); (iii) algorithms for low-rank tensorial models based approximation of multidimensional data for extraction of discriminative features. Algorithms developed under (i) will be applied to semantic segmentation of hyperspectral image of stained frozen section of adenocarcinoma of a colon in a liver, as well as to semantic segmentation of RGB images of stained hitopathological specimens of three frequent cancers of a liver (hepatocellular carcinoma, cholangiocellular carcinoma and adenocarcinoma of colon in a liver). These applications are aimed to quantify contribution of hyperspectral imaging in semantic segmentation, as well as to quantify the quality of various models for semantic segmentation of RGB images of specimens with diagnosed frequent carcinomas of a liver. Algorithms developed under (ii) will be applied to identification of metabolites present in small proportions in 1H NMR spectra of human urine of subjects with diabetes type 2. This approach will rely on extended library (290 to 330) of metabolites indicative for human urine with/without diabetes type 2. This application is important for non-targeted metabolic profiling with the objective to identify as much metabolites as possible present in spectra of biological specimen. Algorithms developed under (ii) and (iii) will be applied to diagnosis of frequent retina diseases through extraction of discriminative features from 3D optical coherence tomography images. This application is important as potential alternative to deep networks that are demanding for training.]]></summary_en></project><project>
<id>15132</id><title_hr><![CDATA[Molekularna, proteomska i ekstrolitska karakterizacija okolišnih i kliničkih izolata Fusarium kompleksa vrsta]]></title_hr><title_en><![CDATA[Molecular, proteomic and extrolite characterization of environmental and clinical Fusarium species complexes]]></title_en><user_id>12487</user_id><user_firstLast_name>Maja Šegvic Klarić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-8062</code><acronim><![CDATA[FUSO-MPE]]></acronim><duration>18.12.2023 - 17.12.2027</duration><status>U tijeku</status><financ_value>165.903,51 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Javno zdravstvo i zdravstvena zaštita, Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Public health and health services, Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Farmaceutsko-biokemijski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Pharmacy and Biochemistry]]></institution_en><team_members_id>12800, 865927, 865926, 22655, 13473, 17888, 865967, 866155, 868461, 19190, 869876, </team_members_id><team_members_names><![CDATA[Daniela Jakšić, Michael Sulyok, Martin Hoenigl, Domagoj Kifer, Sanja Plesko, Sanja Dabelić, Marko Siroglavić, Vanja Kelava, Ida Ćurtović, Zrinka Bošnjak, Marta Kozarić, ]]></team_members_names><keywords_hr><![CDATA[Fusarium fujikuroi, virulencija, antifungalna otpornost, MALDI-TOF, ekstrolitni profil, fuzarinska kiselina]]></keywords_hr><keywords_en><![CDATA[Fusarium fujikuroi, virulence, antifungal resistance, MALDI-TOF, extrolite profiling, fusaric acid]]></keywords_en><summary_hr><![CDATA[Među 22 Fusarium kompleksa vrsta (KV), koji su uglavnom patogeni na biljkama, 10 KV je povezano s fuzariozama u ljudi. Među njima dominiraju F. solani, F. oxysporum i F. fujikuroi KV. Većina istraživanja pokazuje da fuzarije imaju intrinzičnu rezistenciju na antimikotike. Čimbenici virulencije fuzarioza u ljudi za sada su nepoznati. Fusarium vrste posjeduju skupine gena za biosintezu sekundarnih metabolita (ekstrolita) uključujući i mikotoksine, koji su čimbenici virulencije u biljkama. Međutim, uloga mikotoksina u virulenciji kod ljudi je nerazjašnjena. Ciljevi (C) predloženog projekta su: 1) prikupljanje okolišnih (žitarice) i kliničkih (različiti tipovi fuzarioza) sojeva fuzarija i njihova detekcija do razine vrste korištenjem molekularno-bioloških metoda; 2) određivanje rezistencije na antimikotike u kliničkoj primijeni, u okolišnih i kliničkih sojeva fuzarija korištenjem CLSI (Clinical and Laboratory Standards Institute) protokola; 3) proteomska karakterizacija fuzarija (2D elektroforeza i MALDI-TOF/MS) primjenom in vitro (podloge za identifikaciju, rast u biljci) versus ex vivo uvjeta (simulacija fizioloških uvjeta u čovjeku podlogama i temperaturom) kako bi se odredila ekspresija virulentnih proteina, proteina vezanih za rezistenciju na antimikotike i enzima za proizvodnju ekstrolita; te 4) ekstrolitska karakterizacija (LC-MS/MS analize) fuzarija uzgojenih in vitro u odnosu na ex vivo uvjete. Rezultati će pridonijet otkrivanju čimbenika virulencije u patogenezi fuzarioze koji bi mogli biti nova meta za razvoj antimikotika. Analiza ekstrolitskog profila fuzarija in vitro i ex vivo dopunit će proteomsku karakterizaciju, što će pridonijeti rasvjetljavanju uloge ekstrolita u virulenciji tijekom fuzarioze. Rezultati projekta omogućiti će kreiranje proteomske knjižnice fuzarija uzgojenih u in vitro i ex vivo uvjetima što bi moglo pridonijeti boljoj diferencijaciji vrsta unutar fuzarijskih KV, a time i dijagnostici i terapiji fuzarijskih mikoza.]]></summary_hr><summary_en><![CDATA[Among 22 Fusarium species complexes (SC), which are mainly pathogens on plants, 10 SC have been associated with fusarioses in humans; F. solani, F. oxysporum and F. fujikuroi have been the most frequently reported SCs. Several studies point to the intrinsic rather than the acquired resistance to the antifungals in the Fusarium species. Pathogenesis of fusarioses in humans remains quite unknown. Fusarium species possess biosynthetic gene clusters for the production of extrolites including mycotoxins, which are also known as the virulence factors in plants. However, a role of mycotoxins in virulence in humans is quite obscure. The objectives (O) of the proposed project are: 1) collection of environmental (grains) and clinical (all types of fusariosis) Fusaria and their detection to the species level using DNA-based methods; 2) determination of resistance to prescription antimycotics in environmental and clinical strains of Fusaria using Clinical and Laboratory Standards Institute protocols; 3) proteomic characterisation (2D electrophoresis combined with MALDI-TOF/MS) of Fusaria by applying in vitro (identification media, mimicking growth in plant) versus ex vivo conditions (mimicking physiological media and temperature in humans) in order to determine the expression of the specific virulence proteins, the proteins related to antifungal resistance and the enzymes for extrolite production; and 4) the extrolite profiling (LC-MS/MS) of Fusaria grown in vitro versus ex vivo. The results of the project will contribute to elucidating the role of extrolites in virulence as well as the determination of virulence proteins in the pathogenesis of fusariosis, which could be a new target for the development of antimycotics. Overall, the results of the project will allow construction of an in-house proteomic library which might improve differentiation of the species in Fusarium species complexes and facilitate the diagnostics and the therapy of fusariosis.]]></summary_en></project><project>
<id>15135</id><title_hr><![CDATA[Neproteinogene aminokiseline za povećanje konformacijske raznolikosti peptida]]></title_hr><title_en><![CDATA[Increasing the conformational diversity of peptides with non-proteinogenic amino acids]]></title_en><user_id>66</user_id><user_firstLast_name>IVANKA JERIC</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-9617</code><acronim><![CDATA[INCONDI]]></acronim><duration>29.12.2023 - 28.12.2027</duration><status>U tijeku</status><financ_value>184.763,43 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>717, 25282, 715, 865101, 28915, 871145, 873056, </team_members_id><team_members_names><![CDATA[Josipa Suć Sajko, Mateja Matišić, Lidija Brkljačić, Barbara Bogović, Goran Kragol, Franko Pahović, David Šterpin, ]]></team_members_names><keywords_hr><![CDATA[peptides, non-proteinogenic amino acids, synthesis, secondary structures, non-covalent interactions]]></keywords_hr><keywords_en><![CDATA[peptidi, neproteinogene aminokiseline, sinteza, sekundarne strukture, nekovalentne interakcije]]></keywords_en><summary_hr><![CDATA[Procjenjuje se da je oko 800 neproteinogenih aminokiselina (NPAAs)  identificirano u bakterijama, gljivama, biljkama i morskim organizmima, ostavljajući 20 proteinogenih aminokiselina u manjini od 4%. Postojanje mnogo stotina biološki aktivnih prirodnih peptida s jednom ili više NPAA, odražava sposobnost ovih posebnih monomera da daju neka korisna funkcionalna svojstva, koja nisu dostupna u osnovnom skupu od 20 aminokiselina.  NPAAs su svestrani intermedijeri u organskoj sintezi, posebno u razvoju lijekova i intenzivno se koriste u sintezi katalizatora i funkcionalnih materijala. Široka primjenjivost NPAAs čini ih stoga jednom od najvažnijih skupina organskih molekula. S obzirom na njihovu  važnost i široku primjenu, postoji snažna motivacija za pripravu različitih vrsta NPAAs. Mnoge klase NPAAs ostaju neiskorištene zbog nepostojanja sintetskog protokola za njihovu pripravu i/ili dovoljno znanja o njihovom utjecaju na strukturna svojstva molekule u koju su ugrađeni. Da bi doprinijeli rješavanju ovih nedostataka, ovaj projekt ima za cilj proširiti kemijski prostor NPAAs koje bi mogle modulirati konformaciju peptida na definiran i predvidljiv način. To će se postići: (i) sintezom NPAAs izvedenih iz ugljikohidrata, karbašećera i dušikovih heterocikličkih spojeva, (ii) sintezom peptida s ugrađenim NPAAs i njihovom strukturnom karakterizacijom, i (iii) određivanjem nekovalentnih interakcija koje uključuju NPAAs, a koje su odgovorne za usvajanje određene sekundarne strukture. Inspiracija za NPAAs je nađena u prirodnim spojevima opremljenim dobro definiranim trodimenzionalnim strukturama. Predviđena metodologija temelji se na kemijskoj transformaciji ugljikohidrata, karbašećera i dušikovih heterocikličkih spojeva u odgovarajuće aminokiseline. Predviđamo da će peptidi s takvim NPAAs poprimiti konformacijski različite 3D strukture. Planiramo utvrditi ulogu strukture, stereokemije i nekovalentnih interakcija odgovornih za njihovu stabilizaciju.]]></summary_hr><summary_en><![CDATA[It is estimated that about 800 non-proteinogenic amino acids (NPAAs)  have been identified in bacteria, fungi, plants and marine organisms, leaving the 20 proteinogenic amino acids in the minority at 4%.  The prevalence of biologically active natural peptides with one or more NPAAs, reflects the ability of these particular monomers to confer some useful functional properties, not available in the basic set of 20 amino acids. NPAAs are versatile intermediates in organic synthesis, especially in drug discovery and are extensively used in the synthesis of catalysts, and functional materials. Given the importance and application of NPAAs, there is a strong impetus to access various collections of NPAAs. Many classes of NPAAs remain unexploited due to a lack of a synthetic protocol and/or sufficient knowledge about their influence on the structural properties of the molecule into which they are incorporated. Addressing these issues, this project aims to expand the chemical space of NPAAs that could modulate peptide conformation in a defined and predictable way. This will be achieved by: (i) the synthesis of NPAAs derived from carbohydrates, carbasugars and nitrogen containing heterocycles, (ii) the synthesis of peptides with incorporated NPAAs and their structural characterization, and (iii) the determination of the non-covalent interactions involving NPAAs that are responsible for the adoption of a particular secondary structure. The inspiration for  NPAAs is found in natural compounds equipped with well-defined three-dimensional scaffolds. The envisaged methodology is based on the chemical transformation of carbohydrates, carbasugars and nitrogen heterocyclic compounds into related amino acids.  We anticipate that peptides with such NPAAs  will adopt conformationally distinct 3D structures. We plan to determine the role of structure, stereochemistry and non-covalent interactions responsible for their stabilization.]]></summary_en></project><project>
<id>15136</id><title_hr><![CDATA[Optička dijagnostika infekcija kože]]></title_hr><title_en><![CDATA[Optical diagnostics of dermal infections]]></title_en><user_id>1485</user_id><user_firstLast_name>Ivan Štajduhar</user_firstLast_name><svouser_id>25915</svouser_id><svouser_firstLast_name>Matija Milanic</svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-2433</code><acronim><![CDATA[OPTIDERM]]></acronim><duration>21.12.2023 - 20.12.2027</duration><status>U tijeku</status><financ_value>197.190,14 eur</financ_value><scie_area_hr>Tehničke znanosti, Prirodne znanosti, Biomedicina i zdravstvo, </scie_area_hr><scie_area_en>Technological sciences, Natural sciences, Biomedicine and health sciences, </scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Tehnički fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Engineering]]></institution_en><team_members_id>25743, 29059, 29060, 865853, 1071, 865807, 869653, 869865, 872897, </team_members_id><team_members_names><![CDATA[Franko Hržić, Nika Hlaca, Tina Žagar, Marija Kaštelan, Larisa Prpić Massari, Marijana Vičić, Mateo Mikulić, Dominik Vičević, Darijan Jelušić, ]]></team_members_names><keywords_hr><![CDATA[spektralno snimanje, obrada slike, strojno učenje, kolonije bakterija, gljivične kolonije, bakterijski filmovi, kožne infekcije]]></keywords_hr><keywords_en><![CDATA[spectral imaging, image processing, machine learning, bacterial colonies, fungal colonies, bacterial films, skin infections]]></keywords_en><summary_hr><![CDATA[Glavni cilj predloženog istraživanja je olakšavanje uvođenja uređaja za optičko snimanje u kliničku praksu i potpunu laboratorijsku automatizaciju (FLA) radi brže i točnije identifikacije i diferencijacije mikroba infekcija kože i mekog tkiva (SSTI). Specifični ciljevi istraživanja, uključujući kratak opis rada, jesu: (1) Spektralno snimanje SSTI kultura mikroba. Kulture mikroba uobičajenih SSTI-jeva bit će snimane korištenjem VIS-NIR refleksije, fluorescencije i Ramanovog spektralnog snimanja (SI). Za uzgoj mikroba koristit će se različiti supstrati, simulirajući FLA okruženje i stvarne infekcije kože. (2) Spektralno snimanje SSTI in-vivo. Pacijenti oboljeli od SSTI-ja bit će snimljeni korištenjem SI. (3) Razvoj standardiziranih lančanih postupaka za obradu slike. Slike postavljene u bazi podataka stvorenoj s ciljem (4) koristit će se za stvaranje sveobuhvatnog rješenja za automatsku obradu slike (IPPL) radi utvrđivanja optimalne osjetljivosti i specifičnosti identifikacije mikroba SSTI te njihove diferencijacije za FLA i klinički pregled. (4) Stvaranje javno dostupne baze podataka SI slika. Pripremit će se internetsko okruženje baze podataka za pohranu, pristup, upravljanje i dijeljenje spektralnih slika SSTI kultura mikroba (1) i in vivo slika (2).  |  Projekt će uključiti istraživače raznih profesija, sa znanjem i iskustvom u radu s medicinskim hiperspektralnim slikama, mikrobiologiji, obradi medicinskih slika i kliničkoj dermatologiji. Uključene institucije pružit će sve nužno za provedbu predloženog istraživanja: kapacitet za uzgoj mikroba, mogućnost obrade slika, infrastrukturu za pohranu podataka i pristup pacijentima. Rezultati ovog istraživanja, uz standardizaciju sveobuhvatnog lančanog rješenja za obradu spektralnih slika, omogućit će lakšu translaciju tehnologije u kliničku praksu. Razvijena baza podataka spektralnih slika omogućit će i daljnji razvoj novih algoritama za obradu slike od strane šire znanstvene zajednice.]]></summary_hr><summary_en><![CDATA[The main objective of the proposed research is to facilitate translation of optical imaging devices into clinical practise and Full Laboratory Automation (FLA) for a faster and more accurate identification and differentiation of skin and soft tissue infections (SSTI) microbes. Specific objectives of the research, including a brief work description, are: (1) Spectral imaging of SSTI microbe cultures. Microbial cultures of common SSTIs will be imaged using VIS-NIR reflectance, fluorescence and Raman spectral imaging (SI). Different substrates will be used for microbial cultivation, simulating FLA environment and real skin infections. (2) Spectral imaging of SSTI in-vivo. Patients with SSTI will be imaged using SI. (3) Development of standardised image processing pipelines. Images compiled in the database created under objective (4) will be used to create automated image processing pipelines (IPPL) to achieve optimal sensitivity and specificity for identification and differentiation of SSTI microbes for FLA and clinical inspection.(4) Creation of a publicly available database of SI images. An online database environment will be prepared for the storage, access, processing and exchange of spectral images of SSTI microbial cultures (1) and in-vivo images (2). | The project will involve researchers having different backgrounds: medical hyperspectral imaging, microbiology, medical image processing and clinical dermatology. Participating institutions will provide the instrumental, microbial culturing, image processing capabilities, storage infrastructure and patient access needed for the proposed research. The results of this research, including the standardisation of spectral image processing pipelines, will enable a smoother transition of the technology into clinical practise. The database of spectral images developed will enable further development of image processing algorithms by the wider scientific community.]]></summary_en></project><project>
<id>15139</id><title_hr><![CDATA[Molekulski magnetizam u naprednim čvrstim i mekim materijalima]]></title_hr><title_en><![CDATA[Molecular magnetism in advanced solid and soft materials]]></title_en><user_id>2647</user_id><user_firstLast_name>Dijana Žilić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-9292</code><acronim><![CDATA[MOMENT]]></acronim><duration>18.12.2023 - 17.12.2027</duration><status>U tijeku</status><financ_value>197.326,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, Kemija, Interdisciplinarne prirodne znanosti, </scie_field_hr><scie_field_en>Physics, Chemistry, Interdisciplinary natural sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>1213, 3545, 5634, 8238, 866077, 17790, 19005, 872985, 870018, </team_members_id><team_members_names><![CDATA[Dalibor Merunka, Srećko Valić, Tatjana Antonić Jelić, Miroslav Peric, Irina Petreska, Jurica Jurec, Darko Vušak, Miroslava Lukesova, David Kučera-Čavara, ]]></team_members_names><keywords_hr><![CDATA[molekulski magnetizam, spin, ESR, EPR, prijelazni metal, MOF, ionske tekućine, polimer-zeolitni kompoziti]]></keywords_hr><keywords_en><![CDATA[molecular magnetism, spin, ESR, EPR, transition metal, MOF, ionic liquids, polymer-zeolite composites ]]></keywords_en><summary_hr><![CDATA[Molekulski magneti su idealno igralište za fizičare koji istražuju klasični i kvantni magnetizam zbog intrinzičnih kvantnih svojstava elektronskog spina te mogućnosti da se njime upravlja kemijskom sintezom. Naime, fizikalna svojstva poput magnetske anizotropije, spinskih interakcija, faznih prijelaza, spin-crossovera, relaksacijskih vremena, difuzivnosti te molekulske dinamike mogu se modificirati korištenjem odgovarajućih liganada, koordinacijskih iona, razrijeđivanjem spinskih centara, mijenjanjem polarnosti otapala te ugradnjom ojačavala u polimerne matrice. Zbog toga, važan korak u molekulskom magnetizmu, između kemijske sinteze i kontrole spina u uređajima, leži u razumijevanju spinskih svojstava vezano uz strukturna i dinamička svojstva. Zbog stalne potrage za multifunkcionalnim materijalima, sintetizirano je mnoštvo različitih čvrstih i mekih molekulskih magnetskih spojeva. U ovom projektu, istraživat ćemo odabrane napredne materijale s obzirom na njihovu potencijalnu primjenu u pohrani, spintronici, biologiji, transportu naboja te “zelenim” punilima u polimerima ali i zbog njihovih neuobičajenih magnetskih svojstava. Naš fokus bit će usmjeren na spojeve prijelaznih metala, MOF-ove, paramagnetske molekule u tekućinama te polimer-zeolitne kompozite. Glavna eksperimentalna tehnika bit će spektroskopija elektronskom spinskom rezonancijom (ESR) kao idealan alat za dobivanje uvida u lokalna svojstva spinskih centara i mikroskopsku sliku međudjelovanja. Pored standardne CW spektroskopije u X-području, koristit ćemo napredne ESR tehnike poput pulsne, ENDOR i višefrekventne ESR spektroskopije u jakim poljima. Rezultati će biti poduprijeti onima dobivenim rendgenskom difrakcijom, magnetometrijom, DSC-om i SEM-om. Interpretacija eksperimentalnih rezultata bit će zasnovana na spin-Hamiltonian pristupu, fizikalnim modelima te DFT računima. Pored područja molekulskog magnetizma, rezultati projekta mogu utjecati i na područje koordinacijske kemije te kvantnih tehnologija.]]></summary_hr><summary_en><![CDATA[Molecular magnets represent an ideal playground for physicists to study classical and quantum magnetism due to the intrinsic quantum properties of electron spin and the possibility of influencing it through chemical synthesis. Namely, physical properties such as magnetic anisotropy, spin interactions, phase transitions, spin-crossover, relaxation times, diffusivities, and molecular dynamics could be modified by using appropriate ligands, coordination ions, diluting spin centers, changing solvent polarity, and introducing reinforcing agents to polymer matrices. Therefore, the essential step in molecular magnetism, between chemical design and spin control in devices, lies in understanding spin properties related to structural and dynamical properties.Due to the continuous search for new multifunctional materials, many different solid and soft molecular magnetic compounds have been synthesized. In this project, we will investigate selected advanced materials concerning their potential application for storage, spintronics, biology, charge transport, and “green” fillers in polymers, as well as because of their unconventional magnetic properties. Our focus will be on transition metal compounds, MOFs, paramagnetic molecules in liquids, and polymer-zeolite composites. The primary experimental technique will be electron spin resonance (ESR) spectroscopy as an ideal tool for obtaining insights into the local properties of spin centers and a microscopic picture of interactions. Besides standard X-band CW spectroscopy, we will use advanced ESR techniques such as pulse, ENDOR, and multifrequency high-field ESR. These results will be supported by those obtained by X-ray diffraction, magnetometry, DSC, and SEM. The experimental results will be interpreted based on the spin-Hamiltonian approach, physical models, and DFT computations. Beyond the fields of molecular magnetism, the project’s results may also influence the area of coordination chemistry and quantum technologies.]]></summary_en></project><project>
<id>15153</id><title_hr><![CDATA[Istraživanje spolno specifičnih metaboličkih učinaka Sirtuina 3 kod bolesti povezanih s pretilošću]]></title_hr><title_en><![CDATA[Investigating sex-specific metabolic effects of Sirtuin 3 in obesity-related diseases]]></title_en><user_id>703</user_id><user_firstLast_name>Sandra Sobočanec</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-4806</code><acronim><![CDATA[Obese Sirt]]></acronim><duration>15.12.2023 - 14.12.2027</duration><status>U tijeku</status><financ_value>195.706,41 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>22851, 865456, 7391, 23596, 858438, 24803, </team_members_id><team_members_names><![CDATA[Marija Pinterić, Aleksandra  Korać, Tajana Filipec Kanižaj, Ante Piljac, Ena Šimunić, Kate Šešelja, ]]></team_members_names><keywords_hr><![CDATA[Sirtuin 3, spolne razlike, zapadnjačka prehrana, masno tkivo, bolesti povezane s pretilošću]]></keywords_hr><keywords_en><![CDATA[Sirtuin 3, sex differences, western diet, adipose tissue, obesity-related diseases]]></keywords_en><summary_hr><![CDATA[Cilj projekta je istražiti metabolički učinak Sirt3 u spolno specifičnoj regulaciji interakcije masnog tkiva i jetre u razvoju bolesti povezanih s pretilošću. Pretilost pogađa 670 milijuna ljudi diljem svijeta i predstavlja veliki javnozdravstveni izazov. Komplikacije vezane uz pretilost uključuju dislipidemiju, inzulinsku rezistenciju (IR) i hipertenziju, čimbenike koji karakteriziraju metabolički sindrom i potiču razvoj dijabetesa tipa 2 (T2D), nealkoholne bolesti masne jetre (NAFLD), kardiovaskularnih bolesti i raka. Muškarci i žene razlikuju se u stopama pretilosti, a te spolne razlike utječu na razvoj bolesti i odgovor na terapiju. Zato je važno razumjeti ulogu spola u razvoju bolesti povezanih s pretilošću. Ispravna funkcija mitohondrija ključna je za metaboličku homeostazu jer mitohondriji reguliraju korištenje glukoze i lipida. Funkcija mitohondrija značajno ovisi o Sirtuinu 3 (Sirt3), mitohondrijskoj NAD+ ovisnoj deacetilazi koja je važan regulator metaboličkih putova osjetljivih na hranjive tvari i igra ključnu ulogu u patofiziologiji pretilosti. Manjak Sirt3 kod miševa dovodi do metaboličkog sindroma, a prekomjerni unos kalorija smanjuje razinu i aktivnost Sirt3. Iako je učinak Sirt3 na metaboličku homeostazu opsežno proučavan, uloga Sirt3 u odnosu na spolno specifičnu osjetljivost na metaboličke bolesti povezane s pretilošću ostaje nejasna. Ovaj projekt predlaže da Sirt3 i spolni hormoni sinergistički štite od metaboličkog stresa izazvanog WD-om aktivacijom mitohondrijske funkcije i metabolizma lipida u masnom tkivu, što pozitivno utječe na metabolički status jetre. Projekt uključuje pretkliničke studije na kulturama stanica, mišjim modelima i klinička istraživanja u ljudskoj populaciji. Korištenjem najsuvremenijih genetskih, molekularnih i slikovnih tehnologija, kao i metabolomskih analiza, projekt će pomoći razotkriti ulogu Sirt3 u spolno specifičnom razvoju metaboličkih komplikacija povezanih s pretilošću.]]></summary_hr><summary_en><![CDATA[This project investigates metabolic effect of Sirt3 in sex-specific regulation of adipose tissue-liver crosstalk in the development of obesity-related diseases. Obesity affects 670 million people worldwide and represents a major public health challenge. Obesity-related abnormalities include dyslipidemia, insulin resistance, and hypertension, factors characterizing metabolic syndrome and promoting development of type 2 diabetes (T2D), nonalcoholic fatty liver disease (NAFLD), cardiovascular disease and cancer. Men and women differ in obesity rates, and these sex differences influence disease development and response to therapy. Therefore, it is increasingly important to understand the role of sex in the development of obesity-related diseases. Proper mitochondrial function is essential for metabolic homeostasis as mitochondria regulate glucose and lipid utilization. Mitochondrial function is highly dependent on Sirtuin 3 (Sirt3), a mitochondrial NAD+ dependent deacetylase. Sirt3 is an important regulator of nutrient-sensitive metabolic pathways and plays a critical role in the pathophysiology of obesity. Sirt3 deficiency in mice leads to metabolic syndrome, while excessive caloric intake decreases Sirt3 levels and activity. Although the effect of Sirt3 on metabolic homeostasis has been extensively studied, its role in sex-specific susceptibility to obesity-related metabolic diseases is still unclear. The project proposes that Sirt3 and sex hormones synergistically protect against WD-induced metabolic stress by activating mitochondrial function and lipid metabolism in adipose tissue, which positively affects liver metabolic status. Project includes preclinical cell cultures studies, mouse models and clinical research in human population. Using state-of-the-art genetic, molecular, and imaging technologies and metabolomic analyses, the project will help to unravel the role of Sirt3 in sex-specific development of metabolic complications associated with obesity.]]></summary_en></project><project>
<id>15156</id><title_hr><![CDATA[Supramolekulska asimetrična kataliza: Prijenos kiralnosti u koordinacijskim kavezima]]></title_hr><title_en><![CDATA[Supramolecular Asymmetric Catalysis: Chirality Transfer in Coordination Cages]]></title_en><user_id>355</user_id><user_firstLast_name>Srećko Kirin</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-8456</code><acronim><![CDATA[Cage-Cat]]></acronim><duration>15.12.2023 - 14.12.2027</duration><status>U tijeku</status><financ_value>197.160,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>865090, 866003, 865990, 3397, 866010, 3009, 2927, 963, 3493, 866185, 869785, 870491, 21301, 873036, </team_members_id><team_members_names><![CDATA[Marija Bakija, Eszter Barath, Kevin Cariou, Ines Despotović, Gilles Gasser Gasser, Zoran Kokan, Berislav Perić, Tomislav Portada, Đani Škalamera, Sergey Tin, Filip Grdović, Dario Šušnić, Saša Opačak, Alen Martinko, ]]></team_members_names><keywords_hr><![CDATA[koordinacijski kavezi, homogena kataliza, supramolekulska kemija, stereokemija, interakcije domaćin-gost, bioanorganska kemija]]></keywords_hr><keywords_en><![CDATA[coordination cage, homogeneous catalysis, supramolecular chemistry, stereochemistry, host-guest interactions, bioinorganic chemistry]]></keywords_en><summary_hr><![CDATA[Novi pristupi istraživanju multifunkcionalnih katalitičkih sustava vođeni su sve većom potrebom za razvitkom kiralnih lijekova i pojednostavljenjem njihove priprave. Koordinacijski kavezi, koji u principu sadržavaju nekoliko katalitički aktivnih metalnih atoma, nedovoljno su istraženi u enantioselektivnoj katalizi prijelaznim metalima. Visoka enantioselektivnost dobivena je s koordinacijskim kavezima isključivo u slučajevima prostornog ograničavanja katalizatora i/ili supstrata unutar šupljine kaveza koja oponaša ukopano aktivno mjesto enzima, s izvorom kiralnosti u neposrednoj blizini katalitički aktivnog centra. U okviru projektnog prijedloga propitujemo ovaj općeprihvaćen koncept i predlažemo novi katalitički sustav sastavljen od koordinacijskog kaveza u ulozi domaćina i kiralnog gosta. Radna hipoteza je da prijenos kiralnosti s kiralnog gosta na akiralni kavez može prouzročiti enantioselektivnost u katalitičkoj reakciji izvan kaveza. Predviđena je priprava katalitičkih koordinacijskih kaveza izrađenih od različitih prijelaznih metala i liganada koji sadržavanju tri prostorno razdvojene koordinirajuće skupine, a temeljeni su na amidnim, iminskim i acil-hidrazonskim skupinama. Eksperimentalnim i računalnim metodama istraživat će se interakcije domaćin-gost ovih koordinacijskih kaveza u svrhu identificiranja najprikladnijeg gosta za određeni kavez. Kompleksi domaćin-gost koristit će se kao katalizatori u enantioselektivnim reakcijama, uključujući multikatalizu. Također će se istražiti katalitičke reakcije u živim stanicama. Dobiveni rezultati doprinijet će razumijevanju prijenosa kiralnosti u katalitičkim koordinacijskim kavezima i upotrebi koordinacijskih kaveza kao katalitičkih lijekova koji reagiraju na različite podražaje.]]></summary_hr><summary_en><![CDATA[Research on novel approaches to multi-functional catalytic systems is governed by the ever-increasing need for chiral drug discovery, development, and simplification of synthetic procedures thereof. Coordination cages, potentially providing several catalytically active metal centres, are underexploited in enantioselective transition metal catalysis. High enantioselectivity with coordination cages was exclusively obtained in cases of catalyst and/or substrate confinement emulating an &#39;&#39;enzyme pocket&#39;&#39;, with the chiral source in close proximity of a catalytically active centre. Herein we challenge this well-established concept and propose the use of a catalytic system containing a coordination cage host and a chiral guest. The working hypothesis is that the transmission of chirality from the chiral guest to the achiral cage host can induce enantioselectivity of a catalytic reaction outside of the cage. In particular, catalytic coordination cages made of different transition metals and tripodal ligands with amide, imine, and acyl-hydrazone functionalities will be prepared. The host-guest chemistry of these coordination cages will be studied by experimental and computational methods in order to identify the most suitable guests for particular cages. These host-guest complexes will be used as catalysts in enantioselective reactions, including multicatalysis. Further attempts to perform catalytic reactions in living cells will be made. The overall results will contribute to understanding chirality transfer in catalytic coordination cages and establishing the use of coordination cages as multi-stimuli responsive catalytic metalo-drugs.]]></summary_en></project><project>
<id>15157</id><title_hr><![CDATA[Intersubjektivnost hermeneutičkog konsenzusa]]></title_hr><title_en><![CDATA[The Intersubjectivity of Hermeneutic Consensus]]></title_en><user_id>4842</user_id><user_firstLast_name>Jure Zovko</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-5175</code><acronim><![CDATA[IHC]]></acronim><duration>18.12.2023 - 17.12.2027</duration><status>U tijeku</status><financ_value>49.771,05 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filozofija, Interdisciplinarne humanističke znanosti, </scie_field_hr><scie_field_en>Philosophy, Interdisciplinary humanities, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zadru]]></institution_hr><institution_en><![CDATA[University of Zadar]]></institution_en><team_members_id>865629, 5660, 5236, 5375, 5383, </team_members_id><team_members_names><![CDATA[Mate Penava Penava, Marko  Vučetić, Marie-Elise Zovko, Nives Delija Trešćec, Ivana Renić, ]]></team_members_names><keywords_hr><![CDATA[intersubjektivnost; hermeneutika, konsenzus, interpretacija, stručna prosudba, istina, realizam]]></keywords_hr><keywords_en><![CDATA[intersubjectivity, hermeneutics, consensus, interpretation, qualified judgement, istina, realizam]]></keywords_en><summary_hr><![CDATA[Glavni cilj projekta je pokazati nužnost intersubjektivnog pristupa temeljnim problemima filozofije i posebnih znanosti te neodrživost naturalističkog okvira. Iako postoji samo jedna stvarnost zajednička svima, ipak je ovu stvarnost moguće različito tumačiti. Ovdje se pokazuje neizostavnost hermeneutičkog pristupa, jer je svaki problem potrebno razumjeti sa svim njegovim implikacijama te izbjeći jednostrane perspektive. Glavni prigovor protiv intersubjektivnog pristupa bi bio da naglašavanje konsenzusa znači pristajanje uz relativizam. Zbog toga je cilj projekta pokazati kako je relativizam u kontekstu intersubjektivnog konsenzusa moguće izbjeći ako se oslonimo na intersubjektivni konsenzus stručnjaka koji bi u sebe uključivao kriterije racionalnosti, iskrenosti i konvergencije. Kriterij racionalnost jamči da će konsenzus biti plod racionalnog izbora, a ne nekih iracionalnih nagnuća. Kriterij iskrenosti jamči da će konsenzus biti postignut kao plod težnje za istinom, a ne sredstvo za ostvarenje drugih ciljeva. Napokon, kriterij konvergencije kao najvažniji kriterij jamči da će se nešto prihvatiti kao istinito tek kada se stručnjaci za navedeni problem slože oko nekog stajališta uz pretpostavku racionalnosti i iskrenosti. Relativizam se ovdje izbjegava jer nije riječ o pristupu „sve prolazi“ ( „anything goes“), nego se radi o  promišljenom i odvagnutom stajalištu, koje je utemeljeno i čvrsto vezano za stvarnost. Nadalje, naša je tvrdnja da je ovaj konsenzus najviše što se može postići, a da je objektivnost, koja bi trebala biti viši kriterij od ovoga, prazan pojam. Ako takvu objektivnost postavimo kao stajalište da bi svaki intersubjektivni konsenzus mogao biti pogrješan, a da se to nikada ne sazna, onda nam ovako shvaćena objektivnost ne može ničemu poslužiti u rješavanju filozofskih i znanstvenih problema. U svakom drugom slučaju ovaj se pojam objektivnosti poklapa s intersubjektivnim konsenzusom stručnjaka odnosno znanstvene elite u akademskoj zajednici (Lakatos).]]></summary_hr><summary_en><![CDATA[The main aim of the project is to show the necessity of an intersubjective approach to fundamental issues of philosophy and science and the untenability of the naturalist framework. Although only one reality exists common to all of us, this reality can be interpreted differently. The indispensability of a hermeneutical approach is here clear, as it is necessary to understand each problem with all its implications and avoid one sided perspectives. The main objection to an intersubjective approach is that emphasising intersubjective consensus means siding with relativism. Consequently, the goal of the project is to show that relativism is avoidable in this context if we rely on the intersubjective consensus of experts, including in itself the criteria of rationality, sincerity and convergence. The criterion of rationality guarantees the consensus to be a product of rational choice and not of some irrational inclinations. The criterion of sincerity guarantees the consensus to be achieved as a result of the search for truth and not as a means of achieving some other goals. Finally, the criterion of convergence as the most important criterion guarantees that something will be accepted as true only when experts agree on it with the presuppositions of rationality and sincerity.  Relativism is avoided because this is not an &#39;&#39;anything goes&#39;&#39; approach, but a position that is well thought through, weighed off and also founded and closely bound to reality. Furthermore, we claim that this is the maximum that can be achieved and that any notion of objectivity as a higher criterion is an empty notion. If such objectivity is defined as an attitude that any intersubjective consensus can be wrong without ever finding it out, then this objectivity can serve us in no way in resolving philosophical and scientific issues. In any other case, this notion corresponds to the notion of intersubjective consensus of experts, i.e., the scientific elite of the academic community (Lakatos).]]></summary_en></project><project>
<id>15165</id><title_hr><![CDATA[Depresija, samoubojstvo i proteinopatija: rasvjetljavanje odnosa između agregacije i patološkog razvoja]]></title_hr><title_en><![CDATA[Depression, suicide and proteinopathy: elucidating the relationships between aggregation and pathological development]]></title_en><user_id>22771</user_id><user_firstLast_name>Nicholas James Bradshaw</user_firstLast_name><svouser_id>865978</svouser_id><svouser_firstLast_name>Katarina Kouter</svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-2745</code><acronim><![CDATA[DeSPERADo]]></acronim><duration>31.12.2023 - 30.12.2027</duration><status>U tijeku</status><financ_value>199.084,21 eur</financ_value><scie_area_hr>Interdisciplinarno područje znanosti</scie_area_hr><scie_area_en>Interdisciplinary scientific area</scie_area_en><scie_field_hr>Biotehnologija u biomedicini, </scie_field_hr><scie_field_en>Biotechnology in Biomedicine, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Fakultet biotehnologije i razvoja lijekova]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Biotechnology and Drug Development]]></institution_en><team_members_id>29297, 865009, 69, 865959, 865963, 865991, 866153, 865988, 866078, 868725, 868729, 868728, 868730, 869777, 23637, 869974, 871168, 871166, 871386, 871169, </team_members_id><team_members_names><![CDATA[Bobana Samardžija, Maja Juković, Rozi Andretić Waldowski, Abhishek Cukkemane, Oliver H. Weiergräber, Alja Videtič Paska, Tomaž Zupanc, Iris Šalamon Arčan, Mojca Katrašnik, Simone Bernobić, Mohammad Hossain, Andrea Montan, Lora Polašek, Matea Kršanac, Aristea Pavešić Radonja, Ilijana Stanivuk, Barbara Marinčić, Nina Koljđeraj, Julija Šmon, Taja Bedene, ]]></team_members_names><keywords_hr><![CDATA[Genetika, Veliki depresivni poremećaj, Mentalna bolest, Agregacija proteina, Samoubojstvo]]></keywords_hr><keywords_en><![CDATA[Genetics, Major depressive disorder, Mental illness, Protein aggregation, Suicide]]></keywords_en><summary_hr><![CDATA[Klinička depresija/Teški depresivni poremećaj (eng. Major depressive disorder - MDD) jedan je od glavnih uzroka invaliditeta u Europi, dok je samoubojstvo vodeći uzrok nasilne smrti među mladim odraslim osobama. MDD i sklonost samoubojstvu imaju veliki negativan utjecaj na društvo, njihova patofiziologija u određenoj mjeri se preklapa, no njihova biološka osnova je slabo shvaćena. Obje imaju značajnu genetsku podlogu, međutim ona je složena i vrlo heterogena. Kao komplementarni pristup, mi među prvima proučavamo ove psihopatologije kao proteinopatije: poremećaje u kojima se specifični proteini pogrešno savijaju i agregiraju u mozgu. Do sada smo već identificirali nekoliko takvih proteina.U ovom projektu, naša suradnička grupa interdisciplinarno pristupa proučavanju pojava agregacije, njihovih uzroka i posljedica. Kako agregacija vjerojatno proizlazi iz uzajamnog djelovanja genetskih čimbenika i faktora okoliša, predlažemo zajedničko korištenje genetskih i epigenetskih pristupa. Specifično, istraživanje razlike u ekspresiji proteina od interesa kod žrtava samoubojstva i kontrolnih pojedinaca te identifikacija specifičnih rijetkih mutacija s potencijalom za uzrokovanje agregacije. Na razini proteina, koristit ćemo biofizikalne pristupe za proučavanje mehanizama agregacije jednog takvog proteina, TRIOBP-1. Uz to, proučavat ćemo utjecaj stresa na agregaciju proteina u staničnoj kulturi i kako se agregati proteina mogu prenositi među stanicama. Također ćemo karakterizirati nove proteine s potencijalom za agregaciju kako bi se utvrdilo zahtijevaju li daljnje proučavanje. Konačno, ključni rezultati ovih proteina bit će preneseni na vinsku mušicu Drosophila, kako bi se odredili učinci ekspresije proteina, genetike i stresa na ponašanje.Naposlijetku, cilj nam je razviti novi pristup u istraživanju kliničke depresije i suicidalnih sklonosti, s konačnim ciljem poboljšanja identifikacije, dijagnoze i liječenja ovih poremećaja.]]></summary_hr><summary_en><![CDATA[Major depressive disorder (MDD) is one of the largest causes of disability in Europe, while suicide is the leading cause of violent death amongst young adults. Together, MDD and suicidal tendency represent (sometimes overlapping) psychopathologies whose biological basis is poorly understood, but which have a major negative impact on society. Both have significant genetic backgrounds, however these are complex and highly heterogenous. As a complementary approach, we are therefore pioneering the study of these psychopathologies as proteinopathies: disorders in which specific proteins misfold and aggregate in the brain, and have identified several such proteins.In this project, our collaborative group takes an interdisciplinary approach to studying these aggregation events, their causes and consequences. Given that aggregation likely arises from a combination of genetic and environmental factors, we propose to employ genetics and epigenetic approaches to determine whether expression of these proteins differs in suicide victims from control individuals, and whether specific rare mutations might exist in these individuals with the potential to cause aggregation. At the protein level, we will employ biophysical approaches to study the mechanisms of aggregation of one such protein, TROIBP-1. More broadly, we will study the effect of stress on aggregation in cell culture and how such protein aggregates may transmit from cell-to-cell. Novel potential aggregating proteins, will also be characterised to determine if they warrant further study in this regard to proteinopathy. Finally, key results from these proteins will be taken into the fruit fly Drosophila, to determine the effects of these proteins, genetics and stress on behaviour.We therefore aim to advance an emerging and exciting approach to MDD and suicidal tendency research, with the aim ultimately of improving identification, diagnosis and treatment of these conditions.]]></summary_en></project><project>
<id>15166</id><title_hr><![CDATA[Primjena metabolomike, fenotipizacije visoke propusnosti i molekularnih markera u ranoj selekciji na otpornost na bolesti kod razvoja novih sorata vinove loze]]></title_hr><title_en><![CDATA[Application of metabolomics, high-throughput phenotyping and molecular markers in early selection for disease resistance in the development of new grape varieties]]></title_en><user_id>11198</user_id><user_firstLast_name>Darko  Preiner</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-9428</code><acronim><![CDATA[VitiResist]]></acronim><duration>31.12.2023 - 30.12.2027</duration><status>U tijeku</status><financ_value>191.030,59 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, Biotehnologija, Interdisciplinarne biotehničke znanosti, </scie_field_hr><scie_field_en>Agriculture, Biotechnology, Interdisciplinary biotechnical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Agronomski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Agriculture]]></institution_en><team_members_id>20366, 13543, 865816, 865818, 25172, 865834, 13509, 865826, 3132, 13506, 24336, 13517, 13508, 21451, 23658, 872964, </team_members_id><team_members_names><![CDATA[Ivana Tomaz, Jasminka Karoglan Kontić, Petra Štambuk, Ana-Marija Jagatić Korenika, Ana Jeromel, Dragoslav Ivanišević, Zvjezdana Marković, Trapp Oliver, Edi Maletić, Domagoj Stupić, Iva Šikuten, Anita Bošnjak Mihovilović, Željko Andabaka, Darko Vončina, Katarina Martinko, Simona Hofer Geušić, ]]></team_members_names><keywords_hr><![CDATA[Vinova loza, fenotipizacija, oplemenjivanje vinove loze, otpornost, markerima potpomognuta selekcija, otporne sorte]]></keywords_hr><keywords_en><![CDATA[Grapevine, phenotyping, selection, grapevine breeding, resistance, marker-assisted selection ]]></keywords_en><summary_hr><![CDATA[Moderno vinogradarstvo u Hrvatskoj i u svijetu bazira se uglavnom na sortama koje su osjetljive na različite bolesti i štetnike što za posljedicu ima primjenu neodrživo velikih količina pesticida u proizvodnji grožđa. Održivi razvoj vinogradarstva u budućnosti bit će moguć samo povećanjem otpornosti vinove loze kroz stvaranje novih sorata otpornih na bolesti, ali i abiotske stresove uzrokovane klimatskim promjenama. U vodećim vinogradarskim zemljama pokrenuti su oplemenjivački programi s ciljem razvoja novih sorata sa otpornošću na bolesti (otporne sorte), a koje istovremeno pokazuju visoku razinu kvalitete. Nove otporne sorte najčešće su nastale na bazi internacionalnih sorata (uglavnom francuskih i njemačkih) korištenjem klasičnog oplemenjivanja i selekcije potpomognute genetskim markerima (tzv. MAS - Marker Assisted selection).  Hrvatska je bogata autohtonim sortama vinove loze koje su osnova proizvodnje vina, a nisu prisutne u oplemenjivačkim programima drugih zemalja. Prijavitelj je 2015. godine  pokrenuo oplemenjivački program kojemu je dugoročni cilj razvoj otpornih sorata vinove loze stabilne i trajne otpornosti, korištenjem autohtone germplazme u kombinaciji sa različitim izvorima otpornosti koji su prisutni u dosad razvijenim otpornim sortama prikladnih za uzgoj u RH. Ovim projektom planira se unaprijediti sam postupak razvoja novih sorata kroz razvoj i primjenu metabolomičkih bio-markera vezanih uz otpornost na bolesti ili smanjenu osjetljivost na vodni stres i visoke temperature, fenotipizaciju visoke propusnosti, primjenu postojećih metoda selekcije baziranih na molekularnim markerima s ciljem piramidizacije otpornosti te razvoj metode rane procijene kvalitete grožđa u postupku selekcije. Navedenim istraživanjima planira se unaprijediti oplemenjivački postupak s obzirom na brzinu i učinkovitost kao i za razvoj sorata sa trajnom otpornošću na bolesti. ]]></summary_hr><summary_en><![CDATA[Modern viticulture in Croatia and the world is based mainly on varieties that are susceptible to various diseases and pests, which results in the unsustainably large amounts of pesticides used in grape production.  The sustainable development of viticulture in the future will only be possible by increasing the resistance of the grapevine through the development of new varieties resistant to diseases and abiotic stresses caused by climate change. Breeding programs have been launched in the leading wine-growing countries to develop new varieties with resistance to diseases (resistant varieties), which at the same time possess a high level of quality. New resistant varieties were most often created based on international varieties (mainly French and German) using classical breeding and selection supported by genetic markers (MAS - Marker Assisted selection). Croatia is rich in autochthonous grape varieties that are the basis of wine production, and are not present in the breeding programs of other countries. In 2015, the applicant started a breeding program whose long-term goal is the development of resistant varieties of grapevines with stable and durable resistance, using autochthonous germplasm in combination with different sources of resistance that are present in the resistant varieties developed so far suitable for growing in Croatia. This project has a goal to improve the process of grapevine breeding through the development of the application of metabolomic biomarkers associated with disease resistance or reduced sensitivity to water stress and high temperatures, high-throughput phenotyping, the application of existing selection methods based on molecular markers with the aim of pyramiding resistance, and the development of the method for early assessment of grape quality in the selection process. This way breeding process can be improved concerning duration and efficiency for the development of cultivars with durable resistance to diseases. ]]></summary_en></project><project>
<id>15170</id><title_hr><![CDATA[Glikozilacija komponente  komplementa C3 u razvoju šećerne bolesti tipa 1 i autoimunosti]]></title_hr><title_en><![CDATA[Glycosylation of complement component C3 in development of type 1 diabetes and autoimmunity]]></title_en><user_id>11174</user_id><user_firstLast_name>Olga Gornik Kljaić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-3983</code><acronim><![CDATA[GlycoC3 -Diab]]></acronim><duration>16.12.2023 - 15.12.2027</duration><status>U tijeku</status><financ_value>187.935,50 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Farmaceutsko-biokemijski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Pharmacy and Biochemistry]]></institution_en><team_members_id>24884, 22655, 5952, 1288, 866526, 23450, 5336, 867701, 869878, </team_members_id><team_members_names><![CDATA[Najda Rudman, Domagoj Kifer, Toma Keser, Marijana Vučić Lovrenčić, Megan Penno, Grant Morahan, Edita Pape-Medvidović, Branimir Plavša, Marko Dužević, ]]></team_members_names><keywords_hr><![CDATA[glikozilacija, komponenta komplementa C3, autoimunost, šećerna bolest tipa 1, dijagnostika šećerne bolesti, diskriminacija šećerne bolesti]]></keywords_hr><keywords_en><![CDATA[glycosylation, complement component C3, autoimmunity, diabetes type 1, diabetes diagnosis, diabetes discrimination ]]></keywords_en><summary_hr><![CDATA[Šećerna bolest tipa 1 (ŠBT1) velik je epidemiološki problem jer, osim što većinom pogađa djecu i mlade, unatoč svim naporima i napretcima u medicini i kvaliteti života, njena incidencija raste. Također, danas se komponenta autoimunosti, koja se najčešće nalazi u podlozi razvoja ove bolesti, javlja i kod odraslih ispitanika. Razumijevanje podloge razvoja, diskriminacija različitih podskupina oboljelih, pa čak i ispravna dijagnoza predstavljaju goruće kliničke probleme. U našem prijašnjem radu smo pokazali visok dijagnostički potencijal N-glikozilacije plazmatskih proteina i imunoglobulina G u razlikovanju djece s novootkrivenom ŠBT1 te njihovih zdravih braće i sestara (AUC>0.9). Također, cjelogenomska asocijacijska studija identificirala je nikada prijavljenu povezanost C3 gena i glikozilacije. Imajući na umu i sve češća saznanja o ulozi sustava komplementa  u razvoju ŠBT1, nedavno smo razvili metodu analize glikozilacije C3 glikoproteina te pokazali njegovu promijenjenu glikozilaciju u ŠBT1. Kako bismo ispitali hipotezu da ove promjene sudjeluju u podlozi razvoja bolesti i autoimunosti, u ovom ćemo projektu analizirati glikozilaciju C3 u populaciji visokorizične dojenčadi, koja podrazumijeva višestruko uzorkovanje od trudnoće majke pa kroz najranije djetinjstvo, do pojave autoimunosti. Ovaj pristup mogao bi rezultirati izuzetno snažnom alatkom za prevenciju ŠBT1. Također ćemo evaluirati i mogućnost razvoja jednostavnijeg analitičkog pristupa za određivanje detektiranih biljega kako bismo olakšali njegov prijenos u kliničku upotrebu. Kako bi se ispitala razlika u imunološkim procesima u šećernoj bolesti tipa 1 kod djece i odraslih s aspekta glikozilacije, analizirat će se i glikozilacija C3 i IgG-a kod 300 odraslih ispitanika s pozitivnom autoimunosti pankreasa ovisno o razini C-peptida te pozitivitetu autoantitijela što bi doprinijelo boljem razumijevanju i diferencijaciji autoimunih procesa.]]></summary_hr><summary_en><![CDATA[Nowadays type 1 diabetes (T1D) is a big social problem because, in addition to the fact that it mostly affects children and the young, its incidence increases despite all advances in medicine and quality of life. Furthermore, the element of autoimmunity, which is frequently found in the basis of this disease, can also occur in adults. Understanding the background of disease development, discrimination of different subgroups of patients, and correct and timely diagnoses are pressing clinical issues. Recently, we demonstrated the high diagnostic potential of N-glycosylation of total plasma proteins and IgG in differentiating children with recent-onset T1D and developed a glycosylation-based prediction model that may be of clinical value (AUC>0.9). We also identified novel genetic associations of complement component C3 gene with N-glycosylation that could be T1D specific. Bearing in mind the increasing evidence of the role of the complement system in the T1D, we recently developed a method for the analysis of N-glycosylation of C3 glycoprotein and demonstrated its alteration in T1D. To test the hypothesis that these changes play role in the development of disease and autoimmunity, in this project we will analyze C3 N-glycosylation in a population of high-risk infants, which includes multiple samples from pregnancy through early childhood, until the onset of autoimmunity. This approach could provide a powerful tool for T1D prevention and significantly advances the field.  We will also examine the possibility of developing a simpler analytical approach for the detection of identified marker to enable its transfer into clinical practice. To examine differences between immune processes in T1D in children and adults and to contribute the diagnostic discrimination, glycosylation of C3 and IgG will be analyzed in 300 adult subjects with positive pancreatic autoimmunity. N-glycosylation will be put in a connection with levels of C-peptide and the positivity of autoantibodies.]]></summary_en></project><project>
<id>15176</id><title_hr><![CDATA[Prostorne modulacije gvanidina]]></title_hr><title_en><![CDATA[Spatial Modulations of Guanidines]]></title_en><user_id>243</user_id><user_firstLast_name>Davor Margetić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-4385</code><acronim><![CDATA[Space-G]]></acronim><duration>30.12.2023 - 29.12.2027</duration><status>U tijeku</status><financ_value>193.589,50 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>856211, 368, 566, 4851, 869832, 873019, </team_members_id><team_members_names><![CDATA[Petar Štrbac, Zoran Glasovac, Ivana Antol, Anamarija Briš, Antonija Karakaš, Josipa Šajnović, ]]></team_members_names><keywords_hr><![CDATA[Gvanidini, Organska kemija, Bazičnost, Računalna kemija, Molekulsko modeliranje, Senzori, Kataliza]]></keywords_hr><keywords_en><![CDATA[Guanidines, Organic chemistry, Basicity, Computational chemistry, Molecular modelling, Sensors, Catalysis]]></keywords_en><summary_hr><![CDATA[Projekt je usmjeren na proučavanje intrinzičnih svojstava gvanidina, njihove visoke bazičnosti i njihove upotrebe kao katalizatora i anionskih senzora. Istraživački pristup projekta Space-G usko je povezana kombinacija teorijskih i eksperimentalnih studija koje uključuju kvantno-kemijske proračune visoke razine za dizajn, kemijsku sintezu i fizikalno-kemijsku karakterizaciju svojstava novih molekula.Cilj Space-G-a je istražiti temeljna fizikalno-kemijska svojstva (poli)cikličkih gvanidina koji su prostorno modulirani prisutnošću promišljeno postavljenih funkcionalnih skupina.Ciljevi su: a) Dizajn funkcionaliziranih cikličkih gvanidinskih molekularnih sustava; b) Sinteza (poli)cikličkih gvanidinskih molekularnih sustava koji posjeduju funkcionalne skupine primjenom ekološki prihvatljivih sintetskih metoda i njihova spektroskopska i strukturna karakterizacija; c) Detaljan uvid u posljedice ugradnje prostorno bliskih funkcionalnih skupina u strukture gvanidina na (super)bazična svojstva i reakcijske mehanizme primijenjenih organskih reakcija; d) Određivanje anionskog vezanja, katalitičkih i supramolekulskih svojstava funkcionaliziranih gvanidinskih sustava.Dobiveni rezultati unaprijedit će temeljno razumijevanje utjecaja prostorno bliskih supstituenata na fizikalno-kemijske čimbenike koji reguliraju (super)bazičnost gvanidina u cikličkim sustavima. Očekivani rezultati će unaprijediti dizajn, prostornu modulaciju i pripremu novih funkcionaliziranih cikličkih gvanidinskih sustava koji bi se mogli primijeniti u različitim istraživačkim područjima uključujući detekciju aniona, katalizu i supramolekularnu kemiju.Izvedivost predloženog istraživanja opravdana je literaturnim presedanima i dobro dokumentiranim iskustvom istraživačkog tima o istraživačkim temama vezanim uz ovaj projekt.]]></summary_hr><summary_en><![CDATA[Project is focused on study of intrinsic properties of guanidines, their high basicity and their utilization as catalysts and anion sensors. Research approach of the Space-G project is tightly connected combination of theoretical and experimental studies which include high level quantum-chemical calculations for the design, chemical synthesis and physico-chemical characterisation of properties of novel molecules.The goal of Space-G is to investigate fundamental physico-chemical properties of (poly)cyclic guanidines which are spatially modulated by the presence of judiciously positioned functional groups.The objectives are: a) Design of functionalized cyclic guanidine molecular systems; b) Synthesis of (poly)cyclic guanidine molecular systems possessing functional groups by employment of environmentally friendly synthetic methods and their spectroscopic and structural characterization; c) Detailed insight into the consequence of incorporating spatially close functional groups in guanidine structures on (super)basic properties and reaction mechanisms of applied organic reactions; d) Evaluation of anion binding, catalytic and supramolecular properties of functionalized guanidine systems.The obtained results will enhance the fundamental understanding of influence of spatially close substituents on physico-chemical factors governing guanidine (super)basicity in cyclic systems. Expected results will advance design, spatial modulation and preparation of novel functionalized cyclic guanidine systems which could be applied in different research areas including anion sensing, catalysis and supramolecular chemistry.Feasibility of the proposed research is justified by literature precedents and well documented experience of the research team on the research topics related to this project.]]></summary_en></project><project>
<id>15177</id><title_hr><![CDATA[Kemijska sudbina zabrinjavajućih farmaceutika u okolišu: eksperimentalno i računalno istraživanje produkata razgradnje i njihovih ekotoksikoloških svojstava]]></title_hr><title_en><![CDATA[The environmental fate of pharmaceuticals of concern: experimental and computational study of degradation products and their ecotoxicological properties]]></title_en><user_id>5594</user_id><user_firstLast_name>Valerije Vrček</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-2634</code><acronim><![CDATA[Pharma-Eco]]></acronim><duration>29.12.2023 - 28.12.2027</duration><status>U tijeku</status><financ_value>162.917,25 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, Interdisciplinarne prirodne znanosti, </scie_field_hr><scie_field_en>Chemistry, Interdisciplinary natural sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Farmaceutsko-biokemijski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Pharmacy and Biochemistry]]></institution_en><team_members_id>4994, 13603, 864876, 23209, 2878, 865844, 865847, 865894, 869967, </team_members_id><team_members_names><![CDATA[Davor Šakić, Erim Bešić, Anton Radman, Dean Marković, Lea Ulm, Juan Arturo Santaballa, Moises Canle Lopez, Maria Kolympadi Markovic, Antonio Ljulj, ]]></team_members_names><keywords_hr><![CDATA[lijekovi, okoliš, NMR spektroskopija, kloriranje, fotokemija, kvantno-kemijski računi, ekotoksikologija]]></keywords_hr><keywords_en><![CDATA[pharmaceuticals, environment, NMR spectroscopy, chlorination, photochemistry, quantum-chemical calculations, ecotoxicology]]></keywords_en><summary_hr><![CDATA[Kemijska sudbina lijekova je važna znanstvena, okolišna i javnozdravstvena tema. Prihvaćeni termin &#39;&#39;farmakoekologija&#39;&#39; uključuje razumijevanje kemijskih transformacija lijeka induciranih okolišnim uvjetima i određivanje ekotoksikoloških svojstava nastalih razgradnih produkata. Među brojnim čimbenicima koji određuju kemijsku sudbinu nekog lijeka posebno se izdvajaju kloriranje voda i utjecaj sunčevog svjetla. U ovom se projektu istražuju mehanizmi oksidacijskih reakcija (kloriranje) odabranih lijekova i njihove fotokemijski inducirane reakcije. Izbor male biblioteke lijekova (npr. gemfibrozil, metformin ili 5-fluorouracil) temelji se na stupovima informacija kojima se definiraju prioritetni kandidati za Četvrti popis praćenja tvari, a u skladu s Okvirnom direktivom o vodama. Istraživanje kemijskog i ekološkog profila lijekova pretpostavlja interdisciplinaran pristup, institucionalnu suradnju i metodološku sinergiju. U okviru projekta suradnici s pet različitih znanstvenih institucija (8 zavoda, 2 države) koristit će napredne spektroskopske tehnike (NMR/EPR) za in situ praćenje kemijskih reakcija, preparativne alate (LC-MS) za izolaciju produkata, te ekotoksikološka ispitivanja na testnim organizmima normiranim i akreditiranim metodama. Eksperimentalni dio istraživanja bit će podržan intenzivnim korištenjem računalnih tehnika (ab initio, DFT teorijske razine) koje omogućuju predviđanje i tumačenje izmjerenih podataka. Ovakvo integriranje različitih pristupa može poslužiti drugim istraživačima kao orijentacija za redizajn ili implementaciju novih koncepata ispitivanja kemijske sudbine lijekova u okolišu. Dobiveni rezultati o kemijskoj sudbini odabranih kandidata (kemijski sadržaj reakcijske smjese i ekotoksikološki status pojedinih produkata) bit će doprinos stalnom nastojanju mjerodavnih institucija da nadopune službene baze podataka informacijama koje nedostaju.]]></summary_hr><summary_en><![CDATA[The chemical fate of pharmaceuticals is an important scientific, environmental and public health topic. The accepted term „pharmaecology“ includes the knowledge of the chemical transformations of the drug induced by environmental conditions and the determination of the ecotoxicological properties of the degradation products. Among the many factors that determine the chemical fate of a drug, water chlorination and the sunlight irradiation are of special importance. In this project, the mechanisms of chlorination and photochemically induced reactions of selected drugs are investigated. The selection of a small library of drugs (eg gemfibrozil, metformin or fluorouracil) is based on the pillars defining priority candidates for the 4th Watch List, which is in accordance with the Water Framework Directive. Research into the chemical and ecological profile of drugs includes an interdisciplinary approach, institutional cooperation and methodological synergy. As part of the project, collaborators from five different scientific institutions (8 departments, 2 countries) will use advanced spectroscopic techniques (NMR/EPR) for in situ monitoring of chemical reactions, preparative tools (LC-MS) for product isolation, and ecotoxicological assays on test organisms using standardized and accredited methods. The experimental part of the research will be supported by the intensive use of computational techniques (ab initio, DFT theoretical levels) that enable prediction and interpretation of measured data. This integration of different approaches can serve other researchers as an orientation for the redesign or implementation of new concepts for testing the chemical fate of drugs in the environment. The results on the chemical fate of the selected candidates (chemical content of the reaction mixture and ecotoxicological status of individual products) will be a contribution to the constant effort of authority institutions to supplement official databases with missing information.]]></summary_en></project><project>
<id>15178</id><title_hr><![CDATA[Otkrivanje neurorazvojne osnove Downovog sindroma pomoću jedinstvenih organoida ljudskog mozga]]></title_hr><title_en><![CDATA[Revealing the Neurodevelopmental Basis of Down Syndrome on a Unique Human Brain Organoid Model]]></title_en><user_id>12653</user_id><user_firstLast_name>Dinko Mitrečić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-4656</code><acronim><![CDATA[DevDown]]></acronim><duration>25.12.2023 - 24.12.2027</duration><status>U tijeku</status><financ_value>196.429,48 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>2543, 865632, 858430, 865633, 865740, 25615, 865886, 12467, 858356, 867716, 872967, 5534, </team_members_id><team_members_names><![CDATA[Nina Krešić, Ante Plećaš, Ana Bekavac, Olesia Kalmukova, Aoife Murray, Dean Nizetic, Jasmina Isaković, Nina Kosi Bijelic, Paula Stančin, Iva Šimunić, Rafaela Filipan, Zeljka Krsnik, ]]></team_members_names><keywords_hr><![CDATA[Downov sindrom, kortikogeneza, diferencijacija neurona, sinaptogeneza, organoidi mozga, SOD1]]></keywords_hr><keywords_en><![CDATA[Down Syndrom, corticogenesis, neuronal differentiation, synaptogenesis, brain organoids, SOD1]]></keywords_en><summary_hr><![CDATA[Downov sindrom je najčešći kromosomski poremećaj u čovjeka i najčešći uzrok teških dijagnoza poput demencije i srčanih malformacija. Unatoč činjenici da su kod osoba s Downovim sindromom neke regije mozga manje, s plićim brazdama, u usporedbi s mozgom disomičnih osoba, još uvijek ne razumijemo razvojnu osnovu ovih malformacija. Praznine u našem znanju su primarno uzrokovane nemogućnošću modeliranja ljudske kortikogeneze na životinjskim modelima. Također, tkivo ljudskih zametaka je rijetko dostupno i donosi značajne varijabilnosti između uzoraka. Stoga je potreban posve nov metodološki pristup kako bismo razumjeli poremećen razvoj mozga kod Downovog sindroma.Naša grupa je uspostavila jedinstvene stanične linije od osobe koja je mozaik za Downov sindrom, tj. sve uočene razlike između trisomičnih i disomičnih stanica mogu se pripisati isključivo dodatnom setu kromosoma 21. Nadalje, uspostavili smo protokol uzgoja organoida mozga koji tijekom 100 dana diferencijacije razvijaju sve slojeve ljudske moždane kore. Budući da naši preliminarni podaci ukazuju na to da se trisomične stanice diferenciraju na drugačiji način, naša hipoteza je da je razvoj kore mozga kod Downovog sindroma poremećen, što također uključuje poremećeno formiranje sinapsi. U ovom projektu ćemo analizirati kako se trisomični neuroni diferenciraju i kako stvaraju sinapse tijekom razvoja slojeva moždane kore tijekom diferencijacije organoida. Budući da pretpostavljamo kako je gen SOD1 na 21. kromosomu jedan od glavnih uzroka ovih poremećaja, upotrijebit ćemo crispr tehnologiju kojom ćemo ukloniti treću kopiju SOD1 te promatrati mogu li se tako ispraviti neki od uočenih poremećaja.Ovaj projekt će unaprijediti razumijevanje razvojne osnove Downovog sindroma, ali i drugih stanja u kojima se mozak ne razvija normalno. Ako smanjeni broj kopija SOD1 poboljša kortikogenezu, to bi otvorilo mogućnost farmakološkog liječenja fetusa s ciljem smanjenja težine fenotipa ovog kromosomskog poremećaja.]]></summary_hr><summary_en><![CDATA[Down syndrome is the most common human chromosomal disorder and the most common cause of serious health problems like dementia and heart malformations. Despite the fact that in individuals with Down Syndrome some regions of brain are smaller with fewer sulci in comparison to the brains of disomic individuals, developmental basis of these malformations is not known. Lack of data is primarily caused by inability of modeling human corticogenesis in animal models. Moreover, human embryonic tissue is rarely accessible, and it brings inter-individual variability. Thus, we need a potent methodological breakthrough to understand brain development in Down Syndrome. Our group established unique cell lines from a person who is mosaic for Down Syndrome, ie. all observed differences between trisomic and disomic cells are attributed exclusively to additional set of chromosome 21. Moreover, we established protocol for organoids which during 100 days of differentiation develop all layers of human cortex. Since our preliminary data revealed that trisomic cells differentiate in a different pattern, our hypothesis is that development of the cortex in Down Syndrome is impaired, which as well includes perturbed formation of synapses. Thus we will perform analyses in which we will observe how do neurons differentiate and how do they make synapses during differentiation of trisomic organoids. Moreover, since we hypothesize that gene SOD1 at chr. 21 might be one of the major causes of these impairments, we will use crispr to remove the third copy of SOD1 and then observe if some of the impairments might be corrected in this way. This project will improve our understanding of developmental basis of Down syndrome, but as well of other conditions in which brain does not develop normally. If decreased number of copies of SOD1 improves corticogenesis, this might open up possibility to pharmacologically treat fetuses with the goal to reduce the severity of phenotype of this chromosomal disorder.]]></summary_en></project><project>
<id>15182</id><title_hr><![CDATA[Istraživanje jedinstvenih karakteristika mitohondrijskog proteina NME6]]></title_hr><title_en><![CDATA[Exploring the unique properties of the mitochondrial NME6 protein]]></title_en><user_id>1107</user_id><user_firstLast_name>Maja Herak Bosnar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-7420</code><acronim><![CDATA[EXTEND]]></acronim><duration>30.12.2023 - 29.12.2027</duration><status>U tijeku</status><financ_value>189.370,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>20880, 5057, 649, 865835, 25045, 869748, 27625, </team_members_id><team_members_names><![CDATA[Uwe Schlattner, Maja Jazvinšćak Jembrek, Neda Slade, Carlo Petosa, Bastien Proust, Lea Vrbančić, Maja Šutić, ]]></team_members_names><keywords_hr><![CDATA[NME, nm23, NDPK, nukleozid-difosfatske kinaze, RCC1L, WBSCR16, mitohondriji]]></keywords_hr><keywords_en><![CDATA[NME, nm23, NDPK, nucleoside diphosphate kinases, RCC1L, WBSCR16,  mitochondria]]></keywords_en><summary_hr><![CDATA[NME6 je član obitelji nukleozid-difosfatskih kinaza (NDPK/NME/Nm23), enzima koji kataliziraju prijenos terminalnog fosfata s nukleozid-trifosfata na nukleozid-difosfate. Posljednjih godina otkriven je velik broj molekularnih funkcija NDPK/NME povezanih s ljudskim bolestima. Obitelj se sastoji od deset članova podijeljenih u dvije skupine. Članovi Grupe I, NME1-NME4, pokazuju visoku stopu međusobne homologije te s ortolozima u drugih Metazoa. Posjeduju aktivnost NDPK u heksamernom obliku. Članovi Grupe II (NME5-NME9), evolucijski su stariji, pokazuju manju razinu homologije i do danas su slabo proučeni, uključujući NME6. U dosadašnjim istraživanjima otkrili smo važne informacije o ovoj neobičnoj NDP kinazi i riješili mnoge nedoumice. Pozicionirali smo NME6 u matriks mitohondrija, iako ne posjeduje kanonski slijed za ulazak mitohondrij. Suprotno od članova Grupe I, NME6 se nalazi u monomernom stanju što onemogućuje aktivnosti NDP kinaze. Stupa u fizičku interakciju s RCC1L (WBSCR16), proteinom uključenim u sastavljanje mitoribosoma i translaciju na mitoribosomu. Prekomjerna ekspresija proteina NME6 smanjuje respiracijsku sposobnost mitohondrija. U našim prethodnim istraživanjima otkrili smo neočekivana svojstva NME6, a time i proteina NME Grupe II, te otvorili nove puteve istraživanja. U ovom projektu koristit ćemo standardne i najsuvremenije metode za 1) opisivanje nekanonskog ulaska NME6 u mitohondrij, 2) definiranje funkcionalne niše NME6 prilikom ekspresije mitohondrijskih proteina, 3) dobivanje biofizičkih odgovora o oligomernom stanju i enzimatskoj aktivnost i 4) istraživanje interakcijskih područja NME6 i njegovih proteinskih partnera. Uvjereni smo da će naša buduća istraživanja odgovoriti ne samo na brojna pitanja o biologiji obitelji NDPK/NME, već pridonijeti i razumijevanju nekanonskog ulaska proteina u mitohondrij, kontroli oksidativne fosforilacije i mehanizmima sazrijevanja mitohondrijske RNA i sklapanja mitoribosoma, koji još nisu razjašnjeni.]]></summary_hr><summary_en><![CDATA[NME6 belongs to the nucleoside diphosphate kinase (NDPK/NME/Nm23) family of enzymes that catalyze the transfer of the terminal phosphate from nucleoside triphosphates, to nucleoside diphosphates. During recent years, research revealed a growing number of NDPK/NME molecular functions related to human pathologies. The family consists of ten members divided in two groups. Group I members, NME1-NME4, are highly homologous among themselves and with orthologues in other Metazoans. They possess the NDPK activity in the hexameric form. The evolutionary older NME5-NME9 (Group II), display lower mutual homology and remain scarcely studied. Our group provided important information on NME6, an unusual NDP kinase and resolved existing discrepancies. We positioned the NME6 in the mitochondrial matrix, despite the absence of a canonical mitochondrial targeting sequence. Contrary to Group I members, NME6 prefers the monomeric state therefore lacking the NDP kinase activity. Physical interaction was confirmed with RCC1L (WBSCR16), a protein involved in mitoribosome assembly and translation. The overexpression of NME6 reduced the mitochondrial respiration capacity. Thus, our research revealed unexpected properties of NME6 and the NME Group II proteins, and opened new, important research avenues. In this project we will use standard and state-of-the art methods to 1) describe the non-canonical import of NME6 to mitochondria, 2) define its functioning hub within the mitochondrial protein expression, 3) provide biophysical answers to its oligomeric state and enzymatic activity and 4) explore interaction interfaces with its protein partners. We are confident that our research will not only answer questions about the biology of the NDPK/NME family but contribute to the understanding of the non-canonical mitochondrial import in general, the control of oxidative phosphorylation and the mechanisms of maturation of mitochondrial RNA and mitoribosome assembly, which remains poorly understood.]]></summary_en></project><project>
<id>15184</id><title_hr><![CDATA[Komunalna otpadna voda - riznica podataka za procjenu životnog stila i prehrambenih navika u hrvatskim regijama]]></title_hr><title_en><![CDATA[Sewage chemical information mining to assess lifestyle and dietary habits in Croatian regions]]></title_en><user_id>5188</user_id><user_firstLast_name>Ivan Senta</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-5332</code><acronim><![CDATA[SCANNING]]></acronim><duration>18.12.2023 - 17.12.2027</duration><status>U tijeku</status><financ_value>197.093,40 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Interdisciplinarne prirodne znanosti, Kemija, </scie_field_hr><scie_field_en>Interdisciplinary natural sciences, Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>3673, 3674, 5179, 865850, 5158, 25897, 5719, 5739, 4562, 3680, 869779, </team_members_id><team_members_names><![CDATA[Senka Terzić, Marijan Ahel, Ivona Krizman Matasić, Karlo Jambrošić, Iva Mikac, Petar Ujčić, Marin Matošić, Josip Ćurko, Ivana Rumbak, Mira Petrovic, Tin Županović, ]]></team_members_names><keywords_hr><![CDATA[epidemiologija otpadnih voda, biomarkeri, kemijska analiza, alkohol, nikotin, hrana, farmaceutski spojevi]]></keywords_hr><keywords_en><![CDATA[wastewater-based epidemiology, biomarkers, chemical analysis, alcohol, nicotine, food, pharmaceuticals]]></keywords_en><summary_hr><![CDATA[Životni stil i prehrambene navike trenutno se uglavnom procjenjuju tradicionalnim epidemiološkim metodama, kao što su ankete i prodajne statistike. Iako korisne, ove metode imaju mnoga ograničenja zbog svoje subjektivne prirode i/ili nepotpunih podataka. Epidemiologija otpadnih voda (engl. “wastewater-based epidemiology”; WBE ili “sewage chemical information mining”), razmjerno je nov, objektivan, isplativ i pravovremen pristup za dobivanje relevantnih epidemioloških informacija na populacijskoj razini. Temelji se na kemijskoj analizi specifičnih ljudskih urinarnih biomarkera u otpadnoj vodi. WBE se uspješno primjenjuje kao komplementarna metoda za procjenu kolektivne potrošnje ilegalnih droga, ali komunalna otpadna voda potencijalna je riznica brojnih drugih kemikalija koje mogu odražavati životni stil, izloženost zagađivalima i zdravstveno stanje populacije. Međutim, potencijal WBE pristupa za procjenu prehrambenih navika vrlo je slabo istražen te se u literaturi mogu pronaći samo dvije studije. Cilj ovog projekta je istražiti životni stil i prehrambene navike u hrvatskim regijama koristeći inovativan WBE pristup. Studija će obuhvatiti biomarkere konzumacije alkoholnih pića, duhana/nikotina, nekoliko skupina lijekova koji se često zlorabe te razne biomarkere vezane uz prehranu (sastojci hrane biljnog i životinjskog podrijetla, uključujući vitamine), koji će se analizirati spregnutim sustavom tekućinske kromatografije i tandemne spektrometrije masa. Zbog razmjerno velikog broja biomarkera vrlo različitih fizikalno-kemijskih svojstava i koncentracija u otpadnoj vodi, razvit će se i validirati nekoliko visokospecifičnih analitičkih metoda. Primjenjivost pristupa provjerit će se analizom neobrađene komunalne otpadne vode iz šest hrvatskih gradova tijekom dvije sezone kako bi se istražile prostorne i vremenske razlike u životnom stilu i prehrambenim navikama. Rezultati analize otpadnih voda usporedit će se s podacima dobivenim konvencionalnim epidemiološkim metodama.]]></summary_hr><summary_en><![CDATA[Lifestyle and dietary habits are currently assessed mainly with traditional epidemiological methods, such as surveys and sales statistics. Although useful, these methods have many limitations due to their subjective nature and/or incomplete data. Wastewater-based epidemiology (WBE), sometimes referred to as sewage chemical information mining, is a relatively new, objective, cost-effective, and timely approach to obtaining some relevant population-level epidemiological information. It is based on the chemical analysis of specific human urinary biomarkers in wastewater. WBE has been successfully applied as a complementary method to assess collective illicit drug use, but municipal wastewater is a potential treasure trove of numerous other chemicals that may reflect population lifestyle, exposure to contaminants, and health status. However, the potential of WBE to assess dietary habits has hardly been investigated, and only two studies can be found in the literature. The aim of this project is to investigate lifestyle and dietary habits in Croatian regions using an innovative WBE approach. The study will include biomarkers of consumption of alcoholic beverages, tobacco/nicotine, several classes of commonly abused pharmaceuticals, and various biomarkers related to diet (plant-based and animal-based food components, including vitamins), which will be analyzed using liquid chromatography - tandem mass spectrometry. Due to the relatively large number of biomarkers with very different physico-chemical properties and concentrations in wastewater, several highly specific analytical methods will be developed and validated. The applicability of the approach will be tested by analyzing raw municipal wastewater from six Croatian cities during two seasons to investigate spatial and temporal differences in lifestyle and diet. The results of the wastewater analysis will be compared with data obtained using conventional epidemiological methods.]]></summary_en></project><project>
<id>15185</id><title_hr><![CDATA[Biogeneza endosoma u Niemann-Pickovoj bolesti tipa C]]></title_hr><title_en><![CDATA[Endosome biogenesis in Niemann-Pick type C disease]]></title_en><user_id>4828</user_id><user_firstLast_name>Silva Katušić Hećimović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-7325</code><acronim><![CDATA[ENDOGENESIS]]></acronim><duration>31.12.2023 - 30.12.2027</duration><status>U tijeku</status><financ_value>197.611,12 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>865513, 19545, 25337, 19281, 865518, 865473, 868797, 869875, 25906, </team_members_id><team_members_names><![CDATA[Aurelien Roux, Sabina Tahirovic, Lea Vidatić, Ivo Barić, Jean Gruenberg, Matthias Prestel, Božana Blažević, Ana-Marija Bogner, Katarina Trajkovic, ]]></team_members_names><keywords_hr><![CDATA[Endosomi, endolizosomski put, membranska napetost, neurodegeneracija, neuroinflamacija, NPC1, NPC2, rijetke bolesti, vezikularni transport]]></keywords_hr><keywords_en><![CDATA[Endosomes, endolysosomal pathway, membrane tension, neurodegeneration, neuroinflammation, NPC1, NPC2, rare diseases, vesicular trafficking]]></keywords_en><summary_hr><![CDATA[Niemann-Pick-ova bolest tipa C (NPC) smrtna je rijetka nasljedna lizosomska bolest nakupljanja koja uglavnom pogađa djecu. Uzrokovana je mutacijama u genu NPC1 ili NPC2, što dovodi do nakupljanja slobodnog kolesterola i drugih lipida u kasnim endosomima/lizosomima. Molekularni detalji bolesti još uvijek nisu poznati, a trenutna terapija samo ublažava simptome. U ovom projektu ćemo testirati hipotezu da lipidna dishomeostaza u NPCu mijenja biofizička svojstva membrana uzrokujući neispravno sortiranje proteina/lipida i transport vezikula endosoma. Cilj projekta je otkriti patološke promjene u biogenezi endosoma u bolesti NPC koje doprinose fenotipu i koje predstavljaju ključne lipidne/proteinske signale ovog procesa. Prvo, koristeći naše nedavno razvijene fluorescentne probe i fluorescentnu slikovnu konfokalnu mikroskopiju (FLIM), odredit ćemo napetost membrana u NPC1/2-KO u odnosu na HeLa stanice divljeg tipa. Drugo, analizirat ćemo proteom i lipidom kako bismo identificirali ključne molekule biogeneze endosoma koje su promijenjene u NPC1/2-KO stanicama te regulirane promijenjenom napetošću membrana. Treće, budući da bolest NPC pokazuje progresivnu neurodegeneraciju i neuroinflamaciju, dobivene rezultate ćemo translatirati u NPC1/2-mišjim neuronima, mikroglijama i astrocitima - moždanim stanicama primarno pogođenim u NPCu. Na kraju, dobivene rezultate ćemo validirati u fibroblastima NPC1/2 pacijenata i u ljudskim NPC1 moždanim stanicama dobivenim iz CRISPR/Cas9-editiranih induciranih pluripotentnih matičnih stanica. Ovo istraživanje će otkriti  biološki relevantne lipide/proteine koji sudjeluju u deregulaciji membranske napetosti i u promijenjenoj biogenezi endosoma u NPC bolesti. Ove molekule se mogu upotrijebiti za razvoj rane dijagnoze i/ili učinkovite terapije NPC bolesti. Stečena znanja u sklopu ovog projekta mogla bi imati širu primjenu, s obzirom da je disfunkcija endolizosoma karakteristična za niz drugih rijetkih kao i čestih neurodegenerativnih bolesti.]]></summary_hr><summary_en><![CDATA[Niemann-Pick type C disease (NPC) is a fatal rare inherited lysosomal storage disorder that mainly affects children. It is caused by mutations in NPC1 or NPC2 gene leading to accumulation of free cholesterol and other lipids in late endosomes/lysosomes. The molecular details of NPC are still not fully understood and current treatments can only alleviate the symptoms. Here, we will test the hypothesis that lipid dyshomeostasis in NPC alters biophysical properties of the membranes causing defective protein/lipid sorting and trafficking of endocytic vesicles. The goal of this project is to identify pathological changes in endosome biogenesis in NPC that contribute to the phenotype and could instruct us on key lipid/protein signals needed for this process. Firstly, using our recently developed fluorescent probes we will measure membrane tension in living NPC1/2-KO vs. wt HeLa cells by fluorescence-lifetime imaging microscopy (FLIM). Secondly, we will perform proteomics and lipidomics to identify key molecules of endosome biogenesis that are altered in NPC1/2-KO cells and are regulated by altered membrane tension. Thirdly, since NPC has a strong CNS component with profound neurodegeneration and neuroinflammation, we will translate the obtained results to NPC1/2-mouse neurons, microglia and astrocytes – the brain cells that are mainly affected in NPC. Lastly, we will validate the obtained findings in NPC1/2 patient&#39;s fibroblasts and in NPC1 human brain cells derived from CRISPR/Cas9 edited human induced pluripotent stem cells. These studies will identify the biologically relevant lipids/proteins involved in deregulation of membrane tension and endosome biogenesis in NPC. These molecules could be further employed to design an early diagnosis and/or effective therapy against NPC. The knowledge gained through this project could have a broader impact since defects of endolysosomal pathway are shared by a number of other rare as well as more common neurodegenerative disorders.]]></summary_en></project><project>
<id>15190</id><title_hr><![CDATA[Kvantificiranje utjecaja plastike na vodene i kopnene organizme]]></title_hr><title_en><![CDATA[Quantifying Impacts of Plastics on Aquatic and Terrestrial organisms ]]></title_en><user_id>17593</user_id><user_firstLast_name>Nina Marn</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-5901</code><acronim><![CDATA[QPlast]]></acronim><duration>18.12.2023 - 17.12.2027</duration><status>U tijeku</status><financ_value>191.506,40 eur</financ_value><scie_area_hr>Prirodne znanosti, Biotehničke znanosti, Biomedicina i zdravstvo, Tehničke znanosti, </scie_area_hr><scie_area_en>Natural sciences, Biotechnical sciences, Biomedicine and health sciences, Technological sciences, </scie_area_en><scie_field_hr>Biologija, Matematika, Računarstvo, Biotehnologija, Interdisciplinarne prirodne znanosti, </scie_field_hr><scie_field_en>Biology, Mathematics, Computer sciences, Biotechnology, Interdisciplinary natural sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>120, 5519, 6027, 866032, 865940, 23207, 865078, 858403, </team_members_id><team_members_names><![CDATA[Vlado Cuculić, Sunčana Geček, Branimir Hackenberger Kutuzović, Konstadia Lika Lika, Goncalo Marques, Ines Haberle, Marija Purgar, Marina Veseli, ]]></team_members_names><keywords_hr><![CDATA[more, mikroplastika, tlo, zagađenje, otpuštanje, subletalni efekti, okoliš, energijski manjak, ponašanje, gujavice, dinamički energijski budžet, model]]></keywords_hr><keywords_en><![CDATA[microplastic, soil, marine, pollution, leaching, sublethal, environment, energy deficiency, behavior, earthworms, dynamic energy budget, modeling]]></keywords_en><summary_hr><![CDATA[Plastika je sveprisutna. Zbog dojma da je uglavnom inertna, interes za istraživanje manji je od onog za letalne toksikante, iako rezultati nedavnih istraživanja pokazuju značajne subletalne učinke izloženosti plastici. Ovo je osobito alarmantno zbog svakodnevnog porasta proizvodnje i uporabe plastike. (Mikro)plastika djeluje i kao vektor za ksenobiotike i zagađivala, te često degradira fizikalno-kemijska svojstva staništa.Raznoliki načini djelovanja zahtijevaju pristup temeljen na procesima, kako bi bilo moguće povezati izloženost plastici i ostalim zagađivalima s učincima na organizam - uključujući subletalne učinke. Iako dostupna istraživanja sadrže podatke o izloženosti plastici i povezanim zagađivalima, nisu razvijeni alati za kvantificiranje rezultirajućih učinaka na organizam.Modeli koji se temelje na teoriji dinamičih energijskih budžeta (DEB) prate asimilaciju i korištenje energije i materije, te postavljaju temelje za razvoj kvantificirajućih alata. DEB modeli mogu uključivati i toksikokinetiku (apsorpciju i eliminaciju toksikanata) i toksikodinamiku (učinke toksikanata), kvantificirajući tako međuovisnosti između asimilacije energije, izloženosti toksikantima i životnog ciklusa organizma. QPlast će koristiti DEB pristup za razvoj skupa alata za kvantificiranje (sub)letalnih učinaka izloženosti plastici i srodnim zagađivalima.QPlast će:•koristiti pristup za procjenu smanjene asimilacije energije uslijed progutane plastike (pristup razvila predlagateljica projekta), kako bi se kvantificirali učinci plastike na vrste od posebnog ekološkog ili komercijalnog značaja,•razviti ekotoksikološki modul koji uzima u obzir učinke otpuštanja organskih i anorganskih ksenobiotika iz progutane plastike, i•istražiti bihevioralne posljedice izloženosti, koristeći pokuse na gujavicama za usmjeravanje razvoja modela.QPlast će razviti nove kvantificirajuće alate, te će upotrijebiti već dostupne i generirati nove podatke o učincima izloženosti plastici i povezanim zagađivalima.]]></summary_hr><summary_en><![CDATA[Plastics are everywhere. While considered largely inert and therefore lacking the urgency that a lethal toxicant would entail, recent research shows substantial sublethal effects of exposure to plastics. This is particularly alarming because production and use of plastics is increasing.  (Micro)plastics also act as a vector for xenobiotics and pollutants, and often degrade physico-chemical properties of habitats. Accounting for such diverse impacts of plastics requires process-based approaches able to link exposure to plastics and the related pollutants, to organismal effects - including sublethal ones. While recent research provides data on plastic and the related pollutant exposure, tools quantifying the resulting organismal effects have not been developed. Models based on Dynamic Energy Budget (DEB) theory track energy and mass acquisition and utilization, thus providing a framework for development of such tools. DEB models can also include toxicokinetics (uptake and elimination of toxicants) and toxicodynamics (effects of toxicants), thus quantifying interdependencies between energy acquisition, toxicant exposure, and organismal life history.QPlast will utilize DEB approaches to develop a set of tools to quantify (sub)lethal effects of exposure to plastics and the related pollutants. It will: •  use the approach for estimating energy deficiency resulting from plastics ingestion (approach developed by the project applicant) to quantify effects of the exposure on species of special conservation or commercial interest,• develop an ecotoxicological module accounting for effects of organic and inorganic pollutants leaching from ingested plastics, and • investigate behavioral consequences of the exposure, using experiments on earthworms to guide model development. QPlast will develop new quantifying tools, and will make use of the growing body of knowledge on sub-organismal and organism-level effects of exposure to plastics and plastics-related pollutants.]]></summary_en></project><project>
<id>15195</id><title_hr><![CDATA[Optimalno upravljanje i redukcija modela za evolucijske i podacima vođene probleme]]></title_hr><title_en><![CDATA[Optimal control and model reduction for evolution and data driven problems]]></title_en><user_id>866</user_id><user_firstLast_name>Martin Lazar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-5191</code><acronim><![CDATA[Conduction]]></acronim><duration>01.02.2024 - 31.01.2028</duration><status>U tijeku</status><financ_value>168.000,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Dubrovniku]]></institution_hr><institution_en><![CDATA[University of Dubrovnik]]></institution_en><team_members_id>5431, 935, 865867, 4557, 865953, 866054, 866179, 866243, 871129, </team_members_id><team_members_names><![CDATA[Ivica Nakić, Ninoslav Truhar, Enrique Zuazua, Luka Grubišić, Luka Marohnić, Mara Vlašić, Ivan Veselic, Peter Benner, Juan Ricardo Munoz, ]]></team_members_names><keywords_hr><![CDATA[Optimalno upravljanje, redukcija modela, simulation-driven methods, functional calculus, spectral analysis, Lyapunov equation, vibrational systems]]></keywords_hr><keywords_en><![CDATA[Optimal control, model order reduction, simulation-driven methods, functional calculus, spectral analysis, Lyapunov equation, vibrational systems]]></keywords_en><summary_hr><![CDATA[Rješavanje optimizacijskih problema modeliranih parcijalnim diferencijalnim jednadžbama (PDJ) s dodatnim ograničenjima na upravljačku funkciju i/ili stanje sustava jedna je od najizazovnijih zadaća primijenjene matematike. U uspješnom tretmanu takvih problema ključnu ulogu igra međudjelovanje tehnika optimizacije i numeričkih simulacija. Posebno, želja da se postojeći rezultati i algoritmi unaprijede i prilagode  trenutnoj razini numeričkih tehnika i tehnika strojnog učenja zahtijeva razvoj rigoroznog i sofisticiranog matematičkog aparata. U sklopu projekta namjeravamo razviti i istražiti nove numeričke i podacima vođene algoritme s ciljem rješavanja niza bekonačnodimenzionalnih optimizacijskih problema s ograničenjima (constraints). Planiramo dobiti rigorozne rezultate aproksimacije koji će jamčiti robusnost algoritama (s obzirom na dimenziju problema) kako na kvalitativnoj tako i na kvantitativnoj razini. Glavne znanstvene aktivnosti projekta bit će usmjerene na sljedeće visoko relevantne teme koje privlače značajnu pozornost s teorijskog, numeričkog i aplikativnog gledišta: 1. problemi optimalnog upravljanja za evolucijske sustave; 2. spektralna analiza Gramovih operatora. Lyapunovljeva i Riccatijeva jednadžba; 3. numerički funkcijski račun korištenjem reduciranih modela rezolvente; 4. pasivno upravljanje vibracijskim sustavima. Proučavanje svake od ovih tema neće se provoditi izolirano te očekujemo interakcijske i sinergijske učinke. Planirani rezultati bit će od interesa istraživačima iz područja teorije upravljanja (uključujući matematičare i inženjere), PDJ-a i numeričke linearne algebre, građevinskim i strojarskim inženjerima, kao i istraživačima koji se bave znanstvenim računanjem i teorijom operatora. Posebna pozornost posvetit će se razvoju karijere mladih znanstvenika. O tome jasno govori činjenica da je polovica predloženih sredstava namijenjena za njihovo zapošljavanje i osposobljavanje.]]></summary_hr><summary_en><![CDATA[Solving optimization problems modelled by partial differential equations (PDEs) with additional constraints on the controls and/or states is one of the most challenging problems in the context of real-world applications. In their successful treatment the interplay between optimization techniques and numerical simulation plays a key role. In particular, the desire to scale the results and algorithms to the current level of numerical and machine learning techniques requires the development of rigorous and sophisticated mathematical apparatus.Within this project, we aim to address a list of infinite-dimensional constrained optimization problems by developing and exploring novel numerical and data driven algorithms. It is planned to provide rigorous approximation results which will guarantee the robustness (with respect to the dimension of the problem) of the algorithms on both the qualitative as well as quantitative level. The main scientific activities of the project will focus on the following highly relevant topics, attracting significant attention from a theoretical, numerical and applicational point of view:1. Optimal control problems for evolution systems.2. Spectral analysis of Gramian operators. Lyapunov and Riccati equation. 3. Numerical resolvent calculus based on reduced order models.4. Passive control of vibrational systems. The study of each topic will not be done in an isolated manner and we expect interaction and synergy effects. The planned results will be of interest to the control theory community (including both mathematicians and engineers), the PDE and numerical linear algebra community, civil and mechanical engineers, as well as to researchers involved in scientific computing and operator theory.Special attention will be given to the career development of young researchers. This is clearly reflected by the fact that half of the proposed budget is earmarked for their employment and training. ]]></summary_en></project><project>
<id>15197</id><title_hr><![CDATA[Gljive hidrološki aktivnih špiljskih ekosustava Dinarida i njihov bioaktivni potencijal]]></title_hr><title_en><![CDATA[Fungi of hydrologically active Dinaric cave ecosystems and their bioactive potential]]></title_en><user_id>13114</user_id><user_firstLast_name>Ivana Kušan</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-4733</code><acronim><![CDATA[FunCavBioA]]></acronim><duration>31.12.2023 - 30.12.2027</duration><status>U tijeku</status><financ_value>197.603,71 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Interdisciplinarne biotehničke znanosti, Biotehnologija, </scie_field_hr><scie_field_en>Interdisciplinary biotechnical sciences, Biotechnology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>12838, 26553, 865904, 865714, 19871, 27026, 13120, 19148, 868201, 873025, </team_members_id><team_members_names><![CDATA[Olga Malev, Ana Pošta, Krunoslav Bojanić, Lada Lukić Bilela, Roman Ozimec, Petra Kovač Konrad, Neven Matočec, Iva Habinovec, Maja Perečinec, Ivana Saraga, ]]></team_members_names><keywords_hr><![CDATA[mikodiverzitet, bioprospekcija, bioaktivne tvari, krško podzemlje, integrativna taksonomija, bioindikatori, voda u kršu, klimatske promjene]]></keywords_hr><keywords_en><![CDATA[mycodiversity, bioprospecting, bioactive compounds, karst underground, integrative taxonomy, bioindicators, water in karst, climatic change]]></keywords_en><summary_hr><![CDATA[Gljive su nezamjenjivi simbionti, stabilizatori ekološke ravnoteže i razlagači koji omogućuju kruženje tvari i energije. Bioraznolikost gljiva mjeri se u milijunima vrsta, no znanosti je poznato manje od 10% njihovog ukupnog broja. Dinarski krš je u smislu bioraznolikosti i hidrologije jedno od najznačajnijih krških područja svijeta, a gljive su u njemu nedovoljno istražene. Ovaj prostor iznimno je važan za očuvanje zaliha pitke vode, na čiju kvalitetu značajno utječe i njegov živi svijet. Trajni mrak, visoka vlažnost zraka i stabilna temperatura čine špilje prirodnim laboratorijima u kojima su gljive podvrgnute selekcijskim pritiscima što rezultira raznolikim adaptacijskim mehanizmima. Zbog toga očekujemo da ove gljive imaju izniman bioindikatorski i bioprospekcijski potencijal. Ovo je prvo sustavno istraživanje gljiva u dinarskom krškom podzemlju koje će uključiti interdisciplinarna istraživanja u obuhvatu: špiljski ekosustav – ukupna bioraznolikost gljiva – gljivlji organizmi – bioindikatori – profiliranje sekundarnih metabolita – biološki potencijal. Ciljevi projekta su istražiti biološku raznolikost špiljskih gljiva te utvrditi njihove ekološke i biogeografske značajke. Kod odabranih vrsta gljiva testirat će se i biološka aktivnost njihovih ekstrakata, provesti profiliranje sekundarnih metabolita i kemijska karakterizacija potencijalno bioaktivnih tvari. Istraživanja će se provesti u hidrološki aktivnim špiljskim sustavima Hrvatske i Bosne i Hercegovine, u mediteranskoj, alpskoj i kontinentalnoj ekoregiji, na pet različitih geotektonskih jedinica i svim ekološkim nišama. Očekivani rezultati bitno će doprinijeti poznavanju bioraznolikosti i ekoloških odnosa gljiva u krškom podzemlju te pružiti uvid u njihov bioaktivni potencijal s ciljem davanja smjernica budućim biotehnološkim istraživanjima.]]></summary_hr><summary_en><![CDATA[Fungi are irreplaceable symbionts, drivers of ecological balance, and decomposers that enable the cycling of matter and energy. The biodiversity of fungi is measured in millions of species, but less than 10% of their total number is known to science. The Dinaric Karst is one of the most important karst regions in the world in terms of biodiversity and hydrology, where fungi are poorly studied. This area is particularly important for the preservation of drinking water resources, the quality of which is significantly influenced by the organisms living there. Permanent darkness, high humidity and steady temperature make caves natural laboratories in which fungi are exposed to selection pressures that leads to diverse adaptation mechanisms. Therefore, we assume that these fungi have exceptional bioindicator and bioprospecting potential. This is the first systematic study of fungi in the Dinaric Karst involving interdisciplinary research in the scope: cave ecosystem - total fungal biodiversity - fungal organisms - bioindicators - secondary metabolite profiling - biological potential. The objectives of the project are to explore the biodiversity of cave fungi and to ascertain their ecological and biogeographical characteristics. In addition, the biological activity of their extracts will be tested for the selected fungal species, a profile of secondary metabolites will be established, and a chemical characterisation of the potentially bioactive compounds will be carried out. The research will be conducted in hydrologically active cave systems in Croatia and Bosnia and Herzegovina, in Mediterranean, Alpine and Continental ecoregions, in five different geo-tectonic units and all ecological niches. The expected results will make an important contribution to the knowledge of biodiversity and ecological relationships in the karst underground and give insight into the bioactive potential of cave fungi, with the aim of providing guidelines for future biotechnological research.]]></summary_en></project><project>
<id>15199</id><title_hr><![CDATA[Meteorološki tsunamiji: od planetarnih do mezoskalnih procesa]]></title_hr><title_en><![CDATA[Global science of meteotsunamis: from planetary to mesoscale processes]]></title_en><user_id>195</user_id><user_firstLast_name>Ivica Vilibić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-3064</code><acronim><![CDATA[GLOMETS]]></acronim><duration>31.12.2023 - 30.12.2027</duration><status>U tijeku</status><financ_value>171.331,87 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Geofizika, </scie_field_hr><scie_field_en>Geophysics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>865095, 25204, 28651, 865554, 865594, 865525, 865542, 865878, 865334, 17753, 871156, </team_members_id><team_members_names><![CDATA[Iva Tojčić, Petra Zemunik, Petra Pranić, Ahmet Cevdet Yalciner, Gozde Guney Dogan Bingol, Xun Huan, Joan Villalonga, Gabriel Jorda, Iva Dominović Novković, Maja Bubalo, Ana Radovan, ]]></team_members_names><keywords_hr><![CDATA[meteorološki tsunamiji, planetarni valovi, mezoskalni procesi, klima, numerički modeli, stohastički i surogatni modeli]]></keywords_hr><keywords_en><![CDATA[meteotsunamis, planetary waves, mesoscale processes, climate, numerical models, stohastic and surrogate models]]></keywords_en><summary_hr><![CDATA[Meteorološki tsunamiji - atmosferski-uzrokovani oceanski valovi plitkog mora na periodima tsunamija - i općenito neseizmičke oscilacije razine mora na minutnim periodima privukli su veliku pozornost istraživača u posljednjem desetljeću zbog dostupnosti globalnih mjerenja visoke razlučivosti i razvoja združenih modela atmosfere i oceana. Interes je postao još izraženiji nakon eksplozivne erupcije vulkana Hunga u siječnju 2022. godine, koja je stvorila planetarne akustičko-gravitacijske valove u atmosferi i meteorološke tsunamije u oceanima. Stoga prijedlog projekta GLOMETS ima za cilj unaprijediti znanje o dinamici kako planetarnih meteoroloških tsunamija tako i lokalnih događaja, pri tome koristeći sva dostupna mjerenja i numeričke alate, te istražujući: (1) globalni hazard od meteoroloških tsunamija uzrokovanih eksplozivnim vulkanskim erupcijama i udarima asteroida, (2) obalni hazard sa razlučivošću manjoj od kilometra, (3) mogućnost kvantificiranja hazarda meteoroloških tsunamija pomoću klimatskih modela, s ciljem procjene hazarda u budućoj klimi, (4) mogućnost optimizacije i poboljšanja praćenja meteoroloških tsunamija, i (5) primjenu stohastičkih tehnika za kvantifikaciju neodređenosti kod meteoroloških tsunamija. Za postizanje ovih ciljeva koristit će se najsuvremeniji alati, kao što su (1) visokofrekventni podaci razine mora u svjetskim oceanima, (2) globalni i (ispod)kilometarski združeni modeli atmosfere i mora, (3 ) klimatske simulacije, reanalize i klimatski produkti, i (4) tehnike kvantificiranja neodređenosti i metode optimalnog eksperimentalnog dizajna. Projekt okuplja hrvatske i inozemne stručnjake koji prednjače u istraživanju i primjeni predloženih metoda u geoznanostima. Projekt će pri provedbi dati procjene hazarda svih navedenih procesa, koji trenutno ne postoji za meteorološke tsunamije, jer sadašnja istraživanja se uglavnom temelje na reproduciranju pojedinačnih ekstremnih događaja.]]></summary_hr><summary_en><![CDATA[Meteorological tsunamis - atmospheric ocean waves in the tsunami frequency band - and generally nonseismic sea level oscillations on tsunami timescales attracted a lot of attention in the recent decade, due to global availability of high-resolution sea level and ancillary measurements and advancement of both atmospheric and ocean models. This became even accentuated after the century-level event of the Hunga explosive volcano eruption in January 2022, that created global acoustic-gravity waves in the atmosphere and meteotsunamis in the ocean. Therefore, the GLOMETS proposal aims to advance the knowledge on both planetary meteotsunami events and local weather-generated sea level oscillations, gathering all available measurements and numerical tools in researching: (1) global meteotsunami hazards from explosive volcanic eruptions and asteroid impacts, (2) meteotsunami hazards at the sub-kilometre scale from both weather- and explosive volcano-induced events, (3) reproducibility of meteotsunami hazard by climate models, for their eventual assessment in the future climate, (4) eventual optimization and improvement of the meteotsunami monitoring, and (5) developing stochastic techniques for meteotsunami uncertainty quantification. To achieve these objectives, state-of-the-art tools will be used, like (1) global quality-checked high-frequency sea level analyses, (2) coupled atmosphere-ocean global and (sub-)kilometre models, (3) climate simulations, reanalyses and products, and (4) uncertainty quantification techniques and optimal experimental design methods. The project gathers both Croatian and international experts that are at the forefront in the research and applications of the proposed methods. The project at its implementation will provide hazard assessment of all of the quoted processes, that is currently not existing, as being based mostly on reproduction of single meteotsunami events.]]></summary_en></project><project>
<id>15200</id><title_hr><![CDATA[Podacima vođene metode i alati za konstruiranje i inovacije ]]></title_hr><title_en><![CDATA[Data-driven Methods and Tools for Design Innovation]]></title_en><user_id>4471</user_id><user_firstLast_name>Mario Štorga</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-7775</code><acronim><![CDATA[DATA-MATION]]></acronim><duration>18.12.2023 - 17.12.2027</duration><status>U tijeku</status><financ_value>152.900,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, Računarstvo, Interdisciplinarne tehničke znanosti, </scie_field_hr><scie_field_en>Mechnical engineering, Computer sciences, Interdisciplinary technological sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>6397, 19022, 17795, 26400, 863804, 866047, 866158, 24150, 866368, 866369, 867676, 869944, </team_members_id><team_members_names><![CDATA[Stanko Škec, Tomislav Martinec, Marija Majda Perišić, Filip Valjak, Fanika Lukačević, Jelena Šklebar, Tino Stankovic, Peter Torlind, Gaetano Cascini Cascini, Anja Maier Maier, Zvonimir Lipšinić, Robert Mašović, ]]></team_members_names><keywords_hr><![CDATA[podacima vođeno konstruiranje, umjetna inteligencija, automatika konstruiranja, analitika konstruiranja, donošenje odluka, rješavanje problema]]></keywords_hr><keywords_en><![CDATA[data-driven design, artificial intelligence, design automation, design analytics, decision-making, problem-solving]]></keywords_en><summary_hr><![CDATA[Primjena umjetne inteligencije u generiranju inovacija preoblikuje prirodu inovativnih procesa i organizaciju istraživanja. Posljedično, buduća istraživanja u području konstruiranja zasnovanoga na podacima i potpomognutoga umjetnom inteligencijom predstavlja jednu od najuzbudljivijih tema istraživanja koja zahtijeva multidisciplinarne pristupe i sinergiju. Digitalne vizualizacije, računalni modeli i alati umjetne inteligencije trebali bi, u konačnici, industriji omogućiti rješavanje problema rastuće složenosti konstruiranja proizvoda, planiranja proizvodnje i cjelokupnog lanca vrijednosti u razvoju novih proizvoda. Kako bi se omogućio daljnji napredak u opisanom području, cilj predloženoga istraživačkog projekta jest razvoj istraživačkoga okvira za eksperimentalne studije paradigme konstruiranja vođenog podacima. Istraživanje će biti usmjereno na proučavanje alata za podršku automatizaciji procesa konstruiranja koji se temelje na umjetnoj inteligenciji te novih pristupa umjetne inteligencije za naprednu analitiku procesa konstruiranja. Imajući u fokusu navedene ciljeve, predloženi će projekt doprinijeti teoriji i praksi konstruiranja vođenog podacima povezivanjem interdisciplinarnih empirijskih istraživanja, izrade konceptualnih modela i implementacije alata za podršku. Projekt se temelji se na rezultatima prijašnjih dvaju HRZZ projekata iste istraživačke grupe: MINMED I TAIDE. Provedena istraživanja i rezultati bi trebali omogućiti nadilaženje prijašnjih ograničenja procesa konstruiranja (u mjerilu, opsegu i učenju) uzrokovanih različitim ljudskim faktorima. Primjena paradigme konstruiranja vođenog podacima i alata s primjenom umjetne inteligencije za konstruiranje i inovacije te iteracijama učenja tijekom cijeloga životnoga ciklusa proizvoda ili usluga, bi mogla dovesti do kreativnijih te kontinuirano ažuriranih tehničkih rješenja. Konačno, neizbježan je i značajan utjecaj nove paradigme na edukaciju budućih inženjera.]]></summary_hr><summary_en><![CDATA[AI’s most significant economic impact could come from its potential as a new ‘method of invention’ that ultimately reshapes ‘the nature of the innovation process and the organization of R&D’. Consequently, future research on data-driven design and AI in design is one of the most exciting emerging topics for the design research community that requires multidisciplinary approaches and synergy. The augmentation of human intelligence with powerful digital visualizations, computational models, and AI tools should, in the end, enable the industry to address the growing complexity of product design, manufacturing, and the value chain. With the motivation to make the step forward, the objective of the proposed research project is to develop a research framework for experimental studies of the data-driven design paradigm within engineering design and development projects. The specific research focus will be aimed at studying AI tools to support design automation and new frontiers of AI approaches for design analytics, with the goal of fostering human-machine creativity and decision-making within innovation-oriented product and service development projects. The proposed project will contribute to both the theory and practice of data-driven design by bringing together interdisciplinary empirical research, conceptualization, and modeling approaches. It will be built on the results of two previous CSF projects: MINMED and TAIDE. The described research and application of the results should enable overcoming past limitations (in scale, scope, and learning) of design processes. Applying the data-driven paradigm and AI support tools in the design and innovation process may lead to more user-centered, more creative, and continuously updated solutions through learning iterations that span through the entire life cycle of a system. Finally, there are very significant implications on education due to the impact on the curricula of future engineers.]]></summary_en></project><project>
<id>15201</id><title_hr><![CDATA[Radiolitički sintetizirane magnetske nanočestice za efekt hipertermije na stanicama raka]]></title_hr><title_en><![CDATA[Radiolytically synthesized magnetic nanoparticles for hyperthermia effect on cancer cells]]></title_en><user_id>350</user_id><user_firstLast_name>Tanja Jurkin</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-3687</code><acronim><![CDATA[RadMagnNanoHyperT]]></acronim><duration>30.12.2023 - 29.12.2027</duration><status>U tijeku</status><financ_value>190.291,34 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, Interdisciplinarne prirodne znanosti, </scie_field_hr><scie_field_en>Chemistry, Interdisciplinary natural sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>616, 25099, 3671, 4619, 869857, 25290, 874053, </team_members_id><team_members_names><![CDATA[Anđela Pustak, Ivan Marić, Goran Štefanić, Mihaela Matovina, Ivan Ilakovac, Iva Bazina, Ružica Šoić, ]]></team_members_names><keywords_hr><![CDATA[gama-zračenje, magnetske nanočestice, delta-FeOOH, magnetit, magnetska hipertermija, stanice raka, NRF2]]></keywords_hr><keywords_en><![CDATA[gamma-irradiation, magnetic nanoparticles, delta-FeOOH, magnetite, magnetic hyperthermia, cancer cells, NRF2]]></keywords_en><summary_hr><![CDATA[Anizotropne magnetske nanočestice (MNČ) delta-FeOOH i Fe3O4 u obliku diskova i pločaste nanočestice stroncijevog heksaferita (SrHF) sintetizirat će se gama-zračenjem u prisutnosti polimera dietilaminoetil-dekstrana (DEAE-dekstrana). Uz delta-FeOOH i Fe3O4, stroncijev heksaferit (SrFe12O19) posjeduje visoku kristalnu anizotropiju i izvrsna magnetska svojstva te je netoksičan, što čini SrHF pogodnim za ubijanje stanica raka magnetskom hipertermijom. Provest će se magnetska i Mössbauerova mjerenja kako bi se istražila ferimagnetska i/ili superparamagnetska priroda sintetiziranih MNČ. Ove MNČ sintetizirane radiolitičkom metodom koristit će se za ubijanje stanica raka u prisutnosti izmjeničnog magnetskog polja oslobađanjem topline koja rezultira porastom temperature s 41 na 46 °C nastale magnetskim gubicima, tj. efektom magnetske hipertermije (MH). Ključni čimbenici za MH su korištenje materijala s visokom vrijednosti parametra specifične apsorpcije (SAR), koji se definira kao količina energije pretvorene u toplinu po jedinici vremena i mase magnetskog materijala. Očekuje se da će sintetizirane MNČ u obliku diska imati mnogo veće vrijednosti SAR-a od odgovarajućih sferičnih MNČ. Efikasnost magnetskog grijanja uzoraka bit će analizirana kako bi se procijenio njihov potencijal za primjenu u magnetskoj hipertermiji. Ova će se mjerenja izvoditi korištenjem komercijalnog uređaja za magnetsko grijanje koji će se kupiti sredstvima iz ovog projekta. Sintetizirane MNČ će se primijeniti na stanice raka A549 i mjerit će se njihova subcelularna akumulacija i efekt magnetske hipertermije na ubijanje stanica raka. Također će se odrediti citotoksičnost MNČ. Smatra se da magnetska hipertermija stvara reaktivne kisikove vrste, što dovodi do smrti stanica. Posebno ćemo se usredotočiti na moguću aktivaciju transkripcijskog faktora NRF2 i njegovu inhibiciju brusatolom kako bi se poboljšalo ubijanje stanica raka magnetskom hipertermijom.]]></summary_hr><summary_en><![CDATA[The anisotropic disk-shaped delta-FeOOH and Fe3O4 and platelet-shaped strontium hexaferrite (SrHF) magnetic nanoparticles (MNPs) will be synthesized by gamma-irradiation in the presence of diethylaminoethyl-dextran (DEAE-dextran) polymer. In addition to delta-FeOOH and Fe3O4, strontium hexaferrite (SrFe12O19) exhibits high crystalline anisotropy and excellent magnetic properties and is nontoxic, making SrHF suitable for killing cancer cells by magnetic hyperthermia. Magnetic and Mössbauer measurements will be performed to investigate the ferrimagnetic and/or superparamagnetic nature of the synthesized MNPs. These radiolytically synthesized MNPs will be used to kill cancer cells in the presence of an alternating magnetic field by releasing heat resulting in temperature rise from 41 to 46 oC generated by magnetic losses, i.e., magnetic hyperthermia effect (MH). The key points for MH are to use materials with a high specific absorption rate (SAR), which is defined as the amount of energy converted into heat per time and per mass of the magnetic material. It is expected that the synthesized disk-shaped MNPs will have a much higher SAR than corresponding spherical MNPs. The magnetic heating efficiency of the samples will be analysed to evaluate their potential for MH applications. These measurements will be performed using a commercial magnetic heating device to be purchased with funding from this project. The synthesized MNPs will be applied to A549 cancer cells and their subcellular accumulation and the effect of magnetic hyperthermia on killing cancer cells will be measured. The cytotoxicity of MNPs will also be determined. Magnetic hyperthermia is thought to generate reactive oxygen species, leading to cancer cell death. We will specifically focus on the possible activation of transcription factor NRF2 and its inhibition by brusatol to enhance cancer cell killing by magnetic hyperthermia.]]></summary_en></project><project>
<id>15207</id><title_hr><![CDATA[Inaktivacija osteoklastnih progenitora i zaštita kosti u imunosno-posredovanim upalnim bolestima: modeli šećerne bolesti i artritisa]]></title_hr><title_en><![CDATA[Osteoclast progenitor inactivation and bone protection in immune-mediated inflammatory diseases: model of diabetes and arthritis]]></title_en><user_id>3075</user_id><user_firstLast_name>Danka Grčević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-2285</code><acronim><![CDATA[OPTIMIDAL]]></acronim><duration>31.12.2023 - 30.12.2027</duration><status>U tijeku</status><financ_value>179.175,79 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, Clinical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>26491, 865435, 17836, 3895, 2631, 3882, 2978, 29120, 3604, 29486, 866107, 866309, 869821, 872948, 865585, </team_members_id><team_members_names><![CDATA[Masa Filipovic, Sara Aničić, Darja Flegar, Alan Šućur, Tomislav Kelava, Nataša Kovačić, Vedran Katavić, Anita Špehar Uroić, Marina Ikić Matijašević, Katerina Zrinski Petrović, Cristina Sobacchi Sobacchi, Ivo Kalajzic, Marta Radošević, Ozana Jakšić, Valerija Bralić Lang, ]]></team_members_names><keywords_hr><![CDATA[osteoklastni progenitori, šećerna bolest tipa 1, reumatoidni arthritis, mišji modeli, ljudski uzorci, trangenični miševi, razgradnja kosti]]></keywords_hr><keywords_en><![CDATA[osteoclast progenitors, type 1 diabetes, rheumatoid arthritis, mouse models, human samples, transgenic mice, bone resorption]]></keywords_en><summary_hr><![CDATA[Osteoklasti su stanice hematopoetskog podrijetla koje razgrađuju kost. Pojačana razgradnja kosti povezana je s brojnim imunosno-posredovanim upalnim bolestima (IMID), uključujući šećernu bolest tipa 1 (T1D) i reumatoidni artritis (RA). Unatoč tome, molekularni i stanični mehanizmi gubitka kosti i osteoporoze povezane s IMID-ima nisu u potpunosti istraženi. Usporednim istraživanjem mišjeg i ljudskog T1D i RA, cilj nam je otkriti mehanizme aktivacije osteoklasta, u skladu sa suvremenom preporukom da se dosadašnja organski-specifična klasifikacija IMID-a preinači u molekularnu.Naša hipoteza je da periferni osteoklastni progenitori koji izražavaju kemokinske receptore doprinose imunoporozi povezanoj s IMID-ima, zbog njihovog privlačenja na površinu kosti kemokinskim gradijentom i funkcionalne aktivacije izazvane upalom. Stoga očekujemo da uklanjanje definirane subpopulacije osteoklastnih progenitora, pomoću sustava Cre-DTA (podjedinica A difterijskog toksina), može spriječiti gubitak kosti u mišjim modelima T1D i RA. Nadalje, cilj nam je razjasniti zajedničke i specifične mehanizme aktivacije osteoklasta u miševa i bolesnika s T1D i RA.Koristit ćemo streptozotocinski (STZ) mišji model T1D te uzorke periferne krvi bolesnika s T1D. Višestruke niske doze STZ potiču inzulitis i upalne medijatore, vjerodostojno prikazujući patofiziologiju T1D. Analizirat ćemo fenotip, učestalost i aktivnost osteoklastnih progenitora te razgradnju kosti u miševa i ljudi s T1D. Usporedno određivanje profila aktivirajućih receptora na osteoklastnim progenitorima i osteoklastogenog okoliša kod T1D i RA otkrit će zajedničke i za bolest specifične mehanizme aktivacije osteoklasta. Nadalje, testirat ćemo može li DTA-posredovano uklanjanje perifernih CX3CR1+ osteoklastnih progenitora spriječiti osteoporozu, i, suprotno, može li prijenos označenih CX3CR1+ osteoklastnih progenitora poništiti tu zaštitu. Naši rezultati mogu pružiti važna saznanja za razvoj novih osteoprotektivnih tretmana IMID-a.]]></summary_hr><summary_en><![CDATA[Osteoclasts are hematopoietically-derived exclusive bone resorbing cells. Enhanced bone resorption is associated with a number of immune-mediated diseases (IMIDs), including type 1 diabetes (T1D) and rheumatoid arthritis (RA). Nevertheless, molecular and cellular mechanisms of bone loss and osteoporosis in IMIDs are still not fully explored. By parallel investigation of mouse and human T1D and RA, we aim to reveal mechanisms underlying osteoclast activation, in line with the recent intention to reframe organ-based to molecular-based classification of clinically divers IMIDs. We hypothesized that chemokine receptor-expressing peripheral osteoclast progenitors contribute to immunoporosis associated with IMIDs, through their chemokine-driven attraction to bone surfaces and inflammation-induced functional activation. Thus, we expect that ablation of defined subset of osteoclast progenitors, using the Cre-DTA (diphtheria toxin subunit A) system, may prevent bone loss in mouse T1D and RA. Moreover, we aim to resolve common and disease-specific mechanisms of osteoclast activation in mouse and human T1D and RA. We will use streptozotocin (STZ) mouse model of T1D and peripheral blood samples of T1D patients. Multiple low doses of STZ induce insulitis and inflammatory mediators, reliable modeling pathophysiology of T1D. We would assess phenotype, frequency and activity of osteoclast progenitors and bone resorption in mouse and human T1D. Comparative profiling of activating receptors on osteoclast progenitors and osteoclastogenic milieu in T1D and RA would reveal disease-specific and common mechanisms of osteoclast activation. Finally, we will test if DTA-mediated ablation of peripheral CX3CR1+ osteoclast progenitors may prevent osteoporosis, and, contrary, if transfer of labeled CX3CR1+ osteoclast progenitors would reverse this protection. Our results may provide important insights for the development of novel bone-protective treatments in IMIDs.]]></summary_en></project><project>
<id>15210</id><title_hr><![CDATA[Integracija viševremenskih optičkih i radarskih podataka mikrosatelita za detekciju promjena zemljišnog pokrova]]></title_hr><title_en><![CDATA[Fusion of multitemporal Optical and Radar Microsatellite dATa for land cover change detection]]></title_en><user_id>3207</user_id><user_firstLast_name>Damir Medak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-2639</code><acronim><![CDATA[FORMAT]]></acronim><duration>18.12.2023 - 17.12.2027</duration><status>U tijeku</status><financ_value>193.589,50 eur</financ_value><scie_area_hr>Tehničke znanosti, Biotehničke znanosti, </scie_area_hr><scie_area_en>Technological sciences, Biotechnical sciences, </scie_area_en><scie_field_hr>Geodezija, </scie_field_hr><scie_field_en>Geodesy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Geodetski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Geodesy]]></institution_en><team_members_id>17863, 866220, 1275, 3478, 29484, 29755, 869888, </team_members_id><team_members_names><![CDATA[Luka Rumora, Andro Kokeza, Ivan  Balenović, Mario Miler, Dino Dobrinić, Ivan Brkić, Filip Papić, ]]></team_members_names><keywords_hr><![CDATA[fuzija snimki, mikrosateliti, pokrov zemljišta, promjena zemljišnog pokrova, satelitske snimke]]></keywords_hr><keywords_en><![CDATA[image fusion, microsatellite, land cover, change detection, satellite imagery]]></keywords_en><summary_hr><![CDATA[Promjene na pokrovu Zemlje događaju se svakodnevno. Svjedoci smo pojave sve češćih i sve jačih sušnih perioda koji su uzrokovani povećanjem temperature i nedostatkom oborina, a zatim i pojavom poplava, drugih prirodnih nepogoda, urbanizacija ili sječa šuma. Sve vremenske pojave utječu na život ljudi i vegetaciju koja se nalazi u gradovima i izvan njih. Iz tog razloga praćenje promjena u urbanim sredinama i šumskim ekosustavima postaje jedan od najvećih izazova, te jedan od prioriteta EU. Praćenje promjena na velikoj površini u kratkom vremenu moguće je samo koristeći podatke dobivene satelitskim misijama. S obzirom na pojavu sve većeg broja satelita svake godine, koji mogu u kratkom vremenu opažati veliku površinu na Zemlji, postoji potreba za razvojem i integracijom dobivenih podataka kako bi se moglo suočiti sa svim izazovima s kojima se susrećemo. Ubrzanim razvojem satelitskih tehnologija, došlo je do pojave mikrosatelita. Mikrosateliti zbog pristupačne cijene izrade i kratkog vremena koje je potrebno uložiti u odnosu na standardne „velike“ satelite postaju nezamjenjiv alat za proučavanje promjena u prostoru. Glavni fokus našeg istraživanja će biti praćenje promjena u urbanim sredinama s njihovom okolicom, šumskim ekosustavima, kao i područja pogođena prirodnim nepogodama (požari, poplave, vjetrolomi i dr.). Navedena područja su izrazito važna iz konteksta količine promjena u prostoru, te se upravo na njima dešava naviše promjena.Glavno istraživačko pitanje na koje projekt želi odgovoriti je „Koja nova saznanja dobijemo integracijom viševremenskih optičkih i radarskih snimaka mikrosatelita u svrhu praćenja promjena zemljišnog pokrova?“. Odgovor na to pitanje ćemo dobiti analizom podataka dobivenih s postojećih mikrosatelita (radarskih i optičkih) kao i svih mikrosatelita čije je lansiranje planirano za vrijeme provedbe projekta. Analize će se provoditi koristeći metode strojnog i dubokog učenja sa svrhom utvrđivanja što detaljnijih detekcija promjena u prostoru.]]></summary_hr><summary_en><![CDATA[Changes on the Earth&#39;s surface are occurring daily. We are experiencing more frequent and severe droughts caused by the rise in temperature and the absence of precipitation, as well as floods, other natural disasters, urbanization or deforestation. All weather phenomena affect people&#39;s lives and vegetation in cities and outside them. For this reason, monitoring changes in urban environments and forest ecosystems is one of the greatest challenges and priorities of the European Union.Monitoring changes in a large area in a short time is possible only with the help of data obtained by satellite missions. Considering the fact that every year more and more satellites appear that can observe a large area on Earth in a short time, the data obtained must be further developed and integrated to meet all challenges. The rapid development of satellite technology has led to the emergence of microsatellites. Microsatellites are becoming an irreplaceable tool for the study of changes in space, as production costs are affordable and the time required is small compared to conventional &#39;&#39;large&#39;&#39; satellites. Our research focuses on monitoring changes in urban areas and their surroundings, forest ecosystems, and areas affected by natural disasters (fires, floods, storms, etc.). The above-mentioned areas are extremely important in terms of the extent of changes in space, and it is in them that most changes take place.The main research question that the project aims to answer is: &#39;&#39;What are the new insights from integrating optical and radar-based multitemporal microsatellite imagery to monitor land cover changes?&#39;&#39;. We will obtain the answer to this question by analyzing data obtained from existing microsatellites (radar and optical) as well as from any microsatellites scheduled for launch during the implementation of the project. The analyzes will be performed using machine learning and deep learning methods to determine the most detailed detection of changes in space.]]></summary_en></project><project>
<id>15211</id><title_hr><![CDATA[Uloga magnezija u ishrani rajčice: integrativni pristup]]></title_hr><title_en><![CDATA[Role of magnesium in tomato nutrition: integrative approach]]></title_en><user_id>4176</user_id><user_firstLast_name>Branimir Urlić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-7260</code><acronim><![CDATA[InToMag]]></acronim><duration>26.12.2023 - 25.12.2027</duration><status>U tijeku</status><financ_value>193.908,02 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, Biotehnologija, Prehrambena tehnologija, </scie_field_hr><scie_field_en>Agriculture, Biotechnology, Food technology, </scie_field_en><institution_hr><![CDATA[Institut za jadranske kulture i melioraciju krša]]></institution_hr><institution_en><![CDATA[Institute for Adriatic Crops and Karst Reclamation in Split]]></institution_en><team_members_id>5091, 23035, 13544, 26541, 250, 866159, 858446, </team_members_id><team_members_names><![CDATA[Gvozden Dumičić, Marijana Popović, Marko Runjić, Maja Veršić Bratinčević, Ivana Generalić Mekinić, MONICA MARILENA MIAZZI, Zdenko Rengel, ]]></team_members_names><keywords_hr><![CDATA[cijepljenje, podloge, deficijencija, transporteri, kvaliteta ploda]]></keywords_hr><keywords_en><![CDATA[grafting, rootstocks, deficiency, transporters, fruit quality]]></keywords_en><summary_hr><![CDATA[Magnezij (Mg) je treći najčešći kation po količini u biljkama i posljednjih godina definiran kao „zaboravljeni element“ kako bi se naglasila njegova važnost najčešće zanemarena u poljoprivrednoj proizvodnji. Rajčica je jedna od najvažnijih povrćarskih kultura, često uzgajana u zaštićenim prostorima gdje stresori ozbiljno remete  proizvodnju. Jedan od načina za izbjegavanje i smjenjenje gubitaka u proizvodnji rajčice uzrokovanih nepovoljnim uvjetima je cijepljenje rajčice na odgovarajuće podloge. Cijepljenje se smatra efikasnom tehnikom za povećanje usvajanja i efikasnosti korištenja Mg, ali trenutna nedovoljna saznanja pokazuju njegov negativan utjecaj na koncetraciju Mg u listu. To može rezultirati latentnom deficijencijom Mg koja utječe na produkciju ugljikohidrata bitnih za postizanje maksimalnog prinosa za osiguravanje optimalne kvalitete. U okviru ovog projekta napravit će se pregled efikasnosti korištenja Mg kultivara i podloga rajčice. Projektom će se utvrditi utjecaj optimalne i deficitarne opskrbe Mg na izabrane cijepljene podloge i kultivare te mogućnost umanjenja efekta deficijencije Mg dodatnom folijarnom prihranom Mg. Također će se utvrditi razina šećera u listu kao novi dijagnostički alat deficijencije Mg u ovisnosti o primijenjenim tretmanima, kao i određivanja pragova za daljnje korištenje u istraživanjima i oplemenjivanju.   Utjecaj cijepljenja i opskrbe Mg na kvalitetu ploda bit će opširno evaluiran te će utvrditi ekspresija gena Mg transportera u izabranim kombinacijama, kao i utjecaj folijarne prihrane. Dobiveno znanje rezultirat će selekcijama kultivara i podloga rajčice (i ostalog plodovitog povrća) te unaprijediti razumijevanje interakcija podloga/plemka vezano za usvajanje Mg i utjecaj na vegetativni i generativni razvoj. Rezultati imaju potencijal za unaprijediti konkuretnost EU hortikulturnog sektora (primarna proizvodnja i oplemenjivački sektor) i omogućiti početak daljnjih bazičnih i primijenjenih istraživanja u biljnim znanostima. ]]></summary_hr><summary_en><![CDATA[Magnesium (Mg) is the third most abundant cation in plants and in the last years defined as the „forgotten element“, highlighting it importance overlooked in modern crop production. Tomato is one of the most important horticultural crops, often grown in greenhouses where abiotic and biotic stressors seriously limit production. One of the ways to avoid or reduce production losses caused by adverse conditions is to graft tomato onto proper rootstocks. Grafting is considered as efective tool to improve nutrient uptake and use efficiency, but present scarce findings showed negative effect on tomato Mg leaf concentration. This can result in latent Mg deficiency influencing carbohydrate production important for obtaining maximum yield and ensuring optimal crop quality. Within this proposal, screening of cultivars and rootstocks for Mg use efficiency will be done. We propose a way to alleviate possible Mg deficiency in grafted selected rootstocks and cultivars with additional Mg supply (root supply and foliar fertilization). The effect of grafting and fertilization treatments on the fruit quality will be comprehensively evaluated as also Mg transporters gene expression in chosen combinations. The knowledge obtained could gain new techniques for selection of tomato cultivars and rootstocks (and other annual fruit vegetables) and will improve our understanding of rootstock/scion interactions regarding Mg uptake and Mg effects on vegetative and reproductive development. The results have the potential capacity to increase the competitiveness of the EU horticulture sector (primary production and breeding sector) and provide start for further studies at the fundamental and applied levels in plant science. This project deal with plant Mg nutrition and certainly will upgrade this under explored scientific field. Obtained results and gained knowledge should increase overall potential of the project team for establishing a long-term research group.]]></summary_en></project><project>
<id>15215</id><title_hr><![CDATA[Unapređenje istraživanja u ekologiji pomoću otvorene znanosti i meta-znanosti]]></title_hr><title_en><![CDATA[Empowering ecological research via open science and meta-research]]></title_en><user_id>25587</user_id><user_firstLast_name>Antica Čulina</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-2872</code><acronim><![CDATA[EcoOpen]]></acronim><duration>15.12.2023 - 14.12.2027</duration><status>U tijeku</status><financ_value>197.984,55 eur</financ_value><scie_area_hr>Prirodne znanosti, Društvene znanosti, Tehničke znanosti, </scie_area_hr><scie_area_en>Natural sciences, Social sciences, Technological sciences, </scie_area_en><scie_field_hr>Biologija, Računarstvo, Informacijske znanosti, Sociologija, Kognitivna znanost, Interdisciplinarne prirodne znanosti, Interdisciplinarne društvene znanosti, </scie_field_hr><scie_field_en>Biology, Computer sciences, Information sciences, Sociology, Cognitive science, Interdisciplinary natural sciences, Interdisciplinary social sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>2551, 865795, 865797, 865078, 5519, 7242, 866013, 865798, 866109, 868814, 868717, 869810, </team_members_id><team_members_names><![CDATA[Jadranka Pečar Ilić, Ljerka Ostojić, Alfredo Sanchez-Tojar, Marija Purgar, Sunčana Geček, Dragica Šalamon, Alen Vodopijevec, Matthew Grainger, Dominique Roche Roche, Danijela Žanko, Anita Tarandek, Renato Vidić, ]]></team_members_names><keywords_hr><![CDATA[ekologija, otvorena znanost, meta-znanost, FAIR podaci, meta-analiza, sinteza informacija, ankete]]></keywords_hr><keywords_en><![CDATA[ecology, meta-research, open science, FAIR data, meta-analysis, evidence synthesis, surveys]]></keywords_en><summary_hr><![CDATA[Izazov: Izraženi antropogeni utjecaji postavljaju ekološka istraživanja u središte napora za održanje funkcionalnosti ekosustava koji podržavaju život na zemlji. U tom kontekstu ekologija sve više postaje prediktivna i skalabilna znanost. Međutim, prijelaz je otežan jer većina ekologa ne koristi nove prilike za integraciju postojećih podataka na različitim razinama (vremenski, geografski, taksonomski). Da izazov bude veći, nedavno smo utvrdili da velik dio ekoloških istraživanja ostaje neiskorišten. Stoga je važno ubrzano i drastično povećati doseg ekoloških istraživanja.|Rješenje: EcoOpen će biti prvi projekt u ekologiji koji će iskoristiti globalni zamah meta-istraživanja i otvorene znanosti, kako bi omogućio ekolozima da iskoriste bogat fond već postojećih ekološki relevantnih informacija u svojim istraživanjima.| Kako: EcoOpen će razviti metode za povećanje korištenja otvorenih podataka i ostalih artefakata otvorene znanosti u sintezi informacija i šire. Za informirano praćenje razvoja metoda koristit ćemo meta-istrazivački pristup. Meta-istraživanje je interdisiplinarna grana u razvoju koja istražuje sam znanstveni sustav kako bi ga optimizirala. Ukratko, kvantificirati ćemo koristi uporabe artefakata otvorene znanosti, te tehničke i kulturne prepreke njihovu korištenju, te ćemo izraditi modele isplativosti njihovog korištenja. Demonstirat ćemo važnost razvijenih metoda na primjeru nekoliko ključnih ekoloških pitanja koristeći najnovije pristupe sintezi informacija. Jedinstvena kombinacija područja na kojima radim (ekologija, otvorena znanost i meta-istraživanja) te široka međunarodna mreža suradnika, omogućit će uspješno provođenje ovoga inovativnog projekta.| Vizija: Metode razvijene u EcoOpen će olakšati odgovaranje na niz pitanja u ekologiji. Njegovi rezultati imaju potencijal da informiraju znanstvenu reformu. Projekt će služiti za osnivanje prve meta-istraživačku grupe koja se fokusira na ekologiju, dodatno jačajući hrvatsku poziciju u globalnoj znanosti.]]></summary_hr><summary_en><![CDATA[Challenge: Unprecedented anthropogenic pressures put ecological research at the center of efforts to maintain ecosystem services supporting life on earth. In this capacity, ecology is increasingly becoming predictive and scalable science. However, the transition is hampered as most ecologists do not make use of novel opportunities to integrate existing data across scales. Further, much of the ecological research remains unused, as we recently identified. Therefore, it is pressing to drastically empower ecological research. | Solution: EcoOpen will capitalize on the global momentum of meta-research and open science developments. It will use these to develop solutions to reduce unused research and foster scientific breakthroughs by facilitating uptake of a rich landscape of existing ecologically relevant information.| How: We will develop protocols, tools, and methods for the use of open data and other open science artifacts in evidence synthesis and broader. We will guide their development using meta-research approach. Meta-research is a burgeoning interdisciplinary research line that investigates the scientific system to optimize it. Specifically, we will quantify the benefits of open science artifacts and technical and social barriers to their use, building trade-off models. We will demonstrate the benefits of developed tools by addressing several fundamental questions in ecology  on a global scale, using state-of-the-art approaches to evidence synthesis. My unique background in ecology, expertise in open science and meta-research, and wide international network of collaborators, uniquely position me to successfully conduct this innovative project. | Vision: Tools developed in EcoOpen will foster scientific breakthroughs in ecology. Results of EcoOpen have the potential to inform scientific reform. The project will allow me to establish the first meta-research group that focuses on ecology, further strengthening Croatia&#39;s position in a global scientific landscape.]]></summary_en></project><project>
<id>15221</id><title_hr><![CDATA[Apikompleksni i bakterijski krpeljma prenosivi patogeni u domaćih preživača, konja i hematofagnih vektora]]></title_hr><title_en><![CDATA[Apicomplexan and bacterial tick-borne pathogens in domestic ruminants, horses and haematophagous vectors]]></title_en><user_id>939</user_id><user_firstLast_name>Relja Beck</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-7842</code><acronim><![CDATA[ABaVec]]></acronim><duration>28.12.2023 - 27.12.2027</duration><status>U tijeku</status><financ_value>191.400,00 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Veterinarska medicina, </scie_field_hr><scie_field_en>Veterinary medicine, </scie_field_en><institution_hr><![CDATA[Hrvatski veterinarski institut]]></institution_hr><institution_en><![CDATA[Croatian Veterinary Institute]]></institution_en><team_members_id>865510, 6240, 17605, 21270, 864834, 866506, 22712, 7401, 866529, 129, 2743, 23708, 866530, 870686, </team_members_id><team_members_names><![CDATA[Šimun Naletilić, Jelena Gotić, Tomislav Mikuš, Daria Jurković Žilić, Damjan Franjević, Josip Skejo, Tomislav Šarić, Antun Kostelić, Darko Grden, Stjepan Krčmar, Željko Mihaljević, Ante Kasap, Ema Gagović, Nika Konstantinović, ]]></team_members_names><keywords_hr><![CDATA[Krpeljima prenosivi patogeni, hematofagni insekti, prijenos, mali preživači, goveda, konji, zdravlje životinja, genotipizacija]]></keywords_hr><keywords_en><![CDATA[Tick-borne pathogens, hematophagous vectors, transmission, small ruminants, horses,  health, genotyping]]></keywords_en><summary_hr><![CDATA[Krpelji su trenutačno prepoznati kao glavni vektori člankonožaci u prijenosu zaraznih bolesti životinja diljem svijeta, a zbog klimatskih se promjena u budućnosti očekuje godišnji porast broja krpeljno prenosivih bolesti jer toplije vrijeme pogoduje širenju i produljenoj aktivnosti krpelja.  U ranijem „GENOTICKTRECK“projektu u krpeljima smo dokazi patogene od veterinarske važnosti: Anaplasma ovis, A. phagocytophilum, Ehrlichia canis, Ehrlichia sp., &#39;&#39;Candidatus Neoehrlichia lotoris&#39;&#39;, B. canis, B. vulpes, B. microti, B. venatorum , Babesia sp. &#39;&#39;Badger tip A&#39;&#39;, &#39;&#39;Badger tip B&#39;&#39;, B. ovis, Babesia cf. crassa, Babesia sp. &#39;&#39;tavsan&#39;&#39;, Theileria ovis, T. orientalis, T. equi, T. capreoli, H. canis, H. felis, Hepatozoon &#39;&#39;Badger tip&#39;&#39;. Pojavnost bolesti koje su nekoć bile prisutne samo u tropskim područjima. Kao takve, anaplazmoze i piroplazmoze uzrokuju značajne ekonomske gubitke u životinjskoj proizvodnji diljem svijeta  i utječu na dobrobit životinja. Štoviše, u posljednjem desetljeću hemotropne mikoplazme su emergentni patogeni brojnih životinjskih vrsta. Letalni ishod infekcija s A. marginale i T. orientalis/A. bovis goveda u Hrvatskoj otvorila su nova pitanja o prisutnosti različitih vrsta patogena,učestalosti infekcija, proširenosti i utjecaju na zdravlje životinja. Nadalje, nedostaju podaci o genetsku raznolikost uzročnika bolesti prenosivih krpeljima i njihovih bioloških vektorima u malih preživača, goveda i konja unatoč negativnom ekonomskom učinku. Budući da je prijenos hematofagnim insektima nedovoljno istražen, potrebna su dodatna istraživanja kako bi se razjasnio značaj njihove uloge u prijenosu. U predloženom projektu  istražiit ćemo genske raznolikosti i proširenost ovih još uvijek zanemarenih patogena malih preživača, goveda i konja. Osim toga, istražit ćemo njihov utjecaj na zdravlje životinja i prisutnost u krpeljima i drugim hematofagnim kukcima koristeći multidisciplinarni pristup od kliničkog pregleda do filogeneze.]]></summary_hr><summary_en><![CDATA[Ticks are currently recognized as the main arthropod vectors in animals globally and the number of annual tick-borne infections (TBI) is expected to increase in the future due to climate change as the warmer weather favors tick spread and activity. We detected pathogens/genotypes of veterinary importance in an earlier GENOTICKTRECK project in ticks: Anaplasma ovis, A. phagocytophilum, Ehrlichia canis, Ehrlichia sp., “Candidatus Neoehrlichia lotoris”, B. canis, B. vulpes, B. microti, B. venatorum, Babesia sp. “Badger type A”, “Badger type B”, B. ovis, Babesia cf. crassa, Babesia sp. &#39;&#39;tavsan&#39;&#39;, Theileria  ovis, T. orientalis, T. equi,  T. capreoli, H. canis, H. felis,  Hepatozoon „Badger type&#39;&#39;. Diseases that used to be limited only to tropical areas are now increasingly emerging in previously unaffected regions. As such anaplasmosis and piroplasmosis are associated with large economic losses in animal production worldwide and animal welfare. Moreover, in the last decade, haemotrophic Mycoplasma are emerging pathogens that affect numerous animal species. The lethal outcome of A. marginale infection and T. orientalis/A. bovis in Croatian cattle opened new questions on the presence, infection rate, distribution, impact on health, and genetic diversity of tick-borne pathogens and their vectors. There is a lack of information on the presence, infection rate, and distribution of these pathogens in small ruminants, cattle, and horses despite the negative economic impact on livestock production. Since transmission with arthropod vectors is poorly understood, additional studies are needed to clarify whether hematophagous vectors play a role in transmission. Our proposed work will address the gaps in knowledge of these still neglected pathogens in small ruminants, cattle, and horses. Additionally, we will explore their impact on animal health and presence in ticks and other hematophagous insects using a multidisciplinary approach from clinical examination to phylogeny.]]></summary_en></project><project>
<id>15222</id><title_hr><![CDATA[Regulacija stečene invazivnosti raka jajnika u okruženju koje podržava rast matičnih stanica]]></title_hr><title_en><![CDATA[The orchestration of acquired ovarian cancer invasiveness in a stem cell-supporting environment]]></title_en><user_id>3713</user_id><user_firstLast_name>Anamaria Brozović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-5202</code><acronim><![CDATA[ACAIS]]></acronim><duration>31.12.2023 - 30.12.2027</duration><status>U tijeku</status><financ_value>194.851,94 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>17888, 23892, 866011, 866016, 869892, 27624, 870006, 872579, </team_members_id><team_members_names><![CDATA[Sanja Dabelić, Marija Milković Periša, Petra Heffeter, Karl Koehrer, Petra Jadrijević-Mladar, Jurica Baranašić, Lucija Librenjak, Nihal Karakas, ]]></team_members_names><keywords_hr><![CDATA[rak jajnika, otpornost na lijekove, epitelno-mezenhimalna tranzicija, invazivnost, matične stanice raka]]></keywords_hr><keywords_en><![CDATA[ovarian cancer, drug resistance, epithelial-mesenchymal transition, invasiveness, cancer stem cells]]></keywords_en><summary_hr><![CDATA[Često asimptomatski u ranim stadijima bolesti, rak jajnika (OC) poznat je pod nazivom „tihi ubojica“. Karboplatina (CBP) i paklitaksel (TAX) obično su prvi terapijski izbor. Razvoj otpornosti na lijekove glavna je prepreka uspješne terapije. Stanice raka jajnika prolaze kroz epitelno-mezenhimalnu tranziciju (EMT) kako bi metastazirale. Sve je veća potreba za pronalaženjem novih ciljeva terapije i razumijevanja regulacije metastaza kako bi se povećao uspjeh liječenja. Korištenjem različitih bioinformatičkih pristupa opisali smo nekoliko gena i miRNA za koje smo funkcionalno potvrdili da su uključeni u stečenu otpornost OC, metastaziranje potaknuto lijekovima ili u oboje. Preliminarni podaci pokazuju da stanice otporne na CBP u okruženju koje podržava rast matičnih stanica (Matrigel) formiraju cjevaste strukture i invazivnije su u usporedbi s roditeljskim stanicama. Pretpostavka je da postoji korelacija između molekula s dvostrukom ulogom i invazivnosti matičnih stanica raka jajnika. Prvi cilj ovog projekta je uspostaviti OC stanice sa stabilnom prekomjernom ekspresijom molekula od interesa te potvrditi njihovu ulogu u oba procesa in vivo. Drugi cilj je karakterizirati cjevaste strukture u Matrigelu s CBP-otpornim stanicama i istražiti njihovu regulaciju. Treći cilj je pokušati utvrditi ulogu molekula od interesa u formiranju i regulaciji cjevastih struktura i invazivnosti stanica u Matrigelu. Opći cilj ovog projekta je shvatiti molekularne mehanizme koji su odgovorni za regulaciju cjevastih struktura formiranih od strane stanica sa stečenom otpornošću na CBP i invazivnost, te utvrditi njihov odnos s prethodno utvrđenim molekulama od interesa. Dobiveni podaci pomoći će nam da bolje razumijemo kompleksnost stečene OC otpornosti na terapiju i terapijom potaknuto metastaziranje. Ovim projektom definirati će se novi mogući ciljevi terapije matičnih stanica raka jajnika; ciljevi koji objedinjuju dva bitna procesa, otpornost stanica raka i njihov invazivni kapacitet. ]]></summary_hr><summary_en><![CDATA[Ovarian cancer (OC) is the eight-most commonly occurring cancer in women. Carboplatin (CBP) and paclitaxel are usually the first therapy choice. Development of drug resistance is a major obstacle to successful therapy. Frequently, ovarian carcinoma cells undergo an epithelial-mesenchymal transition (EMT). There is an increasing need to find novel therapeutic targets and to understand the regulation of metastases.Previously, we determined genes and miRNAs functionally confirmed to be involved either in acquired resistance, drug-induced metastasizing, or both. Preliminary data show that CBP-resistant cells in stem cell-supporting environment (Matrigel) form tube-like structures and are more invasive compared with parental cells. We hypothesize that the correlation between molecules with dual role, and the invasive capacity of drug-resistant cells in a cancer stem cell-supporting environment exists. The first goal of this project is to establish OC cells with stable overexpression of molecules previously determined to be involved in drug resistance and drug-induced EMT and to confirm their role in drug resistance and/or metastasis in vivo as well. The second goal is to characterize tube-like structures formed in Matrigel by drug-resistant cells and possibly their regulation. The third goal is to explore the probable role of molecules of interest in the formation and regulation of tube-like structures and the invasive capacity of drug-resistant cells in Matrigel. The overall goal of this project is to understand molecular mechanisms behind tube-like structures formed by stem cells with acquired resistance to CBP and increased invasiveness and their correlation with previously determined molecules of interest. Data obtained will help us to understand better the complicity of acquired OC resistance and treatment-induced metastases. The gained knowledge will ensure the discussion of novel targets and approaches for ovarian cancer therapy.]]></summary_en></project><project>
<id>15224</id><title_hr><![CDATA[Otkriće fizike izvan Standardnog modela i poboljšanje preciznosti Standardnog modela na LHC Run III]]></title_hr><title_en><![CDATA[Beyond the Standard Model discovery and Standard Model precision at LHC Run III]]></title_en><user_id>26101</user_id><user_firstLast_name>Tania Robens</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-2520</code><acronim><![CDATA[BSM_SM_LHCIII]]></acronim><duration>15.12.2023 - 14.12.2027</duration><status>U tijeku</status><financ_value>193.250,92 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>865822, 26132, 865576, 865639, 26151, 871139, 872984, 874104, </team_members_id><team_members_names><![CDATA[Rakhi Mahbubani, Eberl Helmut, Andreas Papaefstathiou, Krzysztof Rolbiecki, Aleksander Filip Zarnecki, Mohamed ouchemhou, Martina Vujica, Andrea Gurgone, ]]></team_members_names><keywords_hr><![CDATA[Fenomenologija sudarača, fizika izvan Standardnog modela, prošireni skalarni sektori, korekcije višeg reda, Monte Carlo generatori događaja]]></keywords_hr><keywords_en><![CDATA[Collider phenomenology, Physics beyond the Standard Model, Extended scalar sectors, Higher-order corrections, Monte Carlo Event Generators]]></keywords_en><summary_hr><![CDATA[Godine 2012., na Large Hadron Collider (LHC) sudarivaču u Europskom Centru za nuklearna istraživanja (CERN) otkrivena je dugo tražena Higgsova čestica. Međutim, tim otkrićem potraga za temeljnim gradivnim blokovima prirode (elementarnim česticama) nije gotova. Teoretičari i eksperimentalci već dugi niz godina rade zajedno kako bi razvili teorijske modele koji opisuju elementarne čestice te ih eksperimentalno potvrdili (ili odbacili). Najbolji model koji imamo je Standardni model (SM). Astrofizička mjerenja ukazuju na postojanje tamne tvari, koju SM ne može objasniti. Nadalje, teorijske računske, kao i eksperimentalne, nepreciznosti otvaraju mogućnost postojanja i dodatnih oblika tvari. Planiram istražiti modele s proširenim skalarnim sektorima, gde ću nastaviti graditi na prethodnim studijama s jednostavnim skalarnim proširenjima, na način da ću istražiti procese raspada koji imaju specifična konačna stanja. Za modele koji uključuju moguće kandidate za tamnu materiju planiram eksplicitno proučiti i osmisliti strategije potrage za LHC Run III. Također ću istražiti mogućnosti otkrivanja tih modela na budućim sudarivačima čestica uzimajući u obzir sva poznata ograničenja. Svi ovi projekti omogućit će daljnje podešavanje eksperimentalnih strategija pretraživanja i pružiti novi uvid u naše znanje o strukturi tvari. Drugi dio prijedloga projekta bavi se određivanjem preciznijih teorijskih predviđanja za procese raspršenja gdje je potrebno primijeniti pametne strategije kako bi se odgovarajući doprinosi izračunali unutar raspoloživih računalnih vremenskih skala. Planiram iskoristiti nedavno razvijene metode koje pomažu smanjiti računalne zahtjeve svojstvene takvim izračunima te pružiti važne gradivne elemente za računanje popravki u redu iza reda do vodećeg. Razvijeni javno dostupni alat koristit će i teorijskoj i eksperimentalnoj zajednici.]]></summary_hr><summary_en><![CDATA[In 2012, the Large Hadron Collider (LHC) at the European Center for Nuclear Research (CERN) has found the long sought for Higgs particle. But the search for the underlying building blocks of nature is not over. For many years, theorists and experimentalists have worked together in order to theoretically construct and experimentally verify (or falsify) models explaining the building blocks of nature. Astrophysical measurements point to the existence of dark matter, which cannot be accounted for by the Standard  Model (SM) of particle physics. Furthermore, theoretical and experimental uncertainties allow for additional matter content. I plan to investigate models with extended scalar sectors, where I will build on previous studies with a simple scalar extension, w here I w ill investigate specific decay patterns. For models with dark matter candidates, I plan to explicitely study and devise search strategies for LHC Run III. I also will investigate the discovery prospects of these models at future colliders, including all know n constraints on the model. All of these projects will allow to further tune experimental search strategies and render novel insight into the building blocks of nature. The second part of the proposal deals with the calculation of accurate predictions for collider processes, where smart strategies need to be applied in order to calculate the corresponding contributions within feasible computational time scales. The developed public tools will be of benefit for both the theoretical and experimental community in performing precise simulations of physical processes on feasible time scales. ]]></summary_en></project><project>
<id>15233</id><title_hr><![CDATA[Matematička teorija nove generacije modela interakcije fluida i struktura]]></title_hr><title_en><![CDATA[Mathematical theory of next generation fluid-structure interactions models]]></title_en><user_id>5074</user_id><user_firstLast_name>Boris Muha</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-2962</code><acronim><![CDATA[NextGenFSI]]></acronim><duration>31.12.2023 - 30.12.2027</duration><status>U tijeku</status><financ_value>184.922,69 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>17761, 865599, 865619, 865249, 5872, 23697, 3773, 865641, 866030, 24025, 23758, 871245, 872885, </team_members_id><team_members_names><![CDATA[Marija Galić, Iva Manojlović, Angela Bašić-Šiško, Matija Livaić, Mario Bukal, Ana Radošević, Domagoj Vlah, Martina Bukač, Justin Webster, Suncica Canic, Sarka Necasova, Maria Deliyianni, Filip Ivančić, ]]></team_members_names><keywords_hr><![CDATA[interakcija fluida i struktura, Navier-Stokesove jednadžbe, poroelastičnost, slaba rješenja, poroelastičnost,  konačni elementi, neuronske mreže]]></keywords_hr><keywords_en><![CDATA[fluid-structure interaction, Navier-Stokes eq., poroelasticity, weak solutions, reduced models, diffuse interface, finite elements, neural networks]]></keywords_en><summary_hr><![CDATA[Interakcije fluida sa strukturama (FSI) su sveprisutne u prirodi i tehnologiji. Matematički, one su opisane spregnutim nelinearnim sustavom parcijalnih diferencijalnih jednadžbi. Na primjer, Navier-Stokesove jednadžbe spregnute su s jednadžbama elastičnosti preko pomične granice. Potaknute mnoštvom primjena, u rasponu od biomedicine do nanotehnologije, FSI su vrlo aktivno područje istraživanja u posljednjih nekoliko desetljeća. Postignut je značajan napredak s mnogo izuzetnih rezultata u analizi, znanstvenom računanju i modeliranju. Međutim, vrlo važna pitanja kao što su topološke promjene domene fluida (samopresijecanja i kontakt) i regularnost granice ostaju neriješena i stvaraju usko grlo koje onemogućuje daljnji razvoj i primjenjivost modela. Unatoč tome, sljedeća generacija primjena, posebno u biomedicini (na primjer dizajn umjetne gušterače), zahtijeva nadogradnju standardnih modela FSI-a koja uzima u obzir poroznost strukture i omogućuje određenu filtraciju fluida kroz nju.Cilj ovog projekta je razviti sveobuhvatnu jedinstvenu teoriju FSI-a, koja će olakšati dizajn i analizu odgovarajućih numeričkih shema. Ključ našeg pristupa je promatranje općenitijih verzija FSI-a, koje se temelje na međuodnosu dvaju novih koncepata u kontekstu FSI-a: difuzne granice i poroelastičnog medija. Ideja prvog je zamijeniti granicu tankim prijelaznim slojem između tekuće i čvrste faze, što je blisko povezano s filtracijom fluida kroz čvrstu fazu i direktno vodi na poroelastični model strukture. Ovakva generalizacija biti će opravdana rigoroznim izvodom klasičnih FSI problema i relevantnih reduciranih FSI modela kao singularnih limesa u odgovarajućim režimima parametara. U numeričkim simulacijama kombinirat ćemo klasične metode konačnih elemenata s novim saznanjima u dubokim neuronskim mrežama.]]></summary_hr><summary_en><![CDATA[Fluid-structure interactions (FSI) are ubiquitous in nature and technology. Mathematically, they are described by a coupled nonlinear system of partial differential equations. For instance, the Navier-Stokes equations are coupled to elasto-dynamics across the moving interface. Motivated by a plethora of applications ranging from biomedicine to nanotechnology, the last few decades have been a very active research period in FSIs. Significant progress has been made with many deep results in analysis, scientific computing and modeling. However, very important questions such as topological changes of the fluid domain (self-intersections and contact) and regularity of the interface remain unresolved and create a bottleneck that prevents further developments and applicability of models. Nevertheless, next generation of applications, particularly in biomedicine (for example design of artificial pancreas), requires an upgrade of standard FSI models to take into account porosity of the structure and to allow some fluid filtration through it.This project aims to develop a comprehensive unified FSI theory, which will facilitate design and analysis of corresponding numerical schemes. The key to our approach is to consider more general versions of FSI problems, which are based on the interplay between two novel concepts in the context of FSI: a diffuse interface and a poroelastic solid. The idea of the former is to replace the interface by a thin transition region between the fluid and the solid phase, which is intimately related with the fluid filtration through the solid phase, thus giving rise to a poroelastic model for the structure. This generalization will be justified by showing that classical FSI problems and relevant reduced FSI models can be recovered as singular limits in suitable parameter regimes.  In the numerical computations we will combine classical finite elements methods with recent advances in deep neural networks.]]></summary_en></project><project>
<id>15240</id><title_hr><![CDATA[Nerelativistička supergravitacija i primjene]]></title_hr><title_en><![CDATA[Non-relativistic supergravity and applications]]></title_en><user_id>865552</user_id><user_firstLast_name>Jan Rosseel</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-5980</code><acronim><![CDATA[NRSUGRA]]></acronim><duration>15.12.2023 - 14.12.2027</duration><status>U tijeku</status><financ_value>113.225,83 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>23722, 3313, 3433, 869922, </team_members_id><team_members_names><![CDATA[Bergshoeff Eric, Maro Cvitan, Predrag Dominis Prester, Sara Zeko, ]]></team_members_names><keywords_hr><![CDATA[teorija struna, supergravitacija, opća relativnost, supersimetrija, AdS/CFT korespondencija]]></keywords_hr><keywords_en><![CDATA[string theory, supergravity, General Relativity, supersymmetry, AdS/CFT correspondence]]></keywords_en><summary_hr><![CDATA[Motiviran potencijalnim primjenama na holografiju i neperturbativne aspekte kvantne teorije polja, projekt će konstruirati nove nerelativističke teorije supergravitacije u 10, 11 i 3 dimenzije. Da bismo to učinili, koristit ćemo se nedavnim uvidima u Newton-Cartanovu geometriju, temelj diferencijalne geometrije za opisivanje nerelativističkih prostor-vremena, i njegovu povezanost s Riemannovom geometrijom putem najsuvremenijih nerelativističkih graničnih postupaka. U 10 i 11 dimenzija usredotočit ćemo se na maksimalne nerelativističke teorije supergravitacije koje se mogu promatrati kao niskoenergetski opisi nerelativističkih struna i M-teorije. Koristit ćemo ih za proučavanje dualnosti i svojstava p-brana u nerelativističkoj teoriji struna. Nadalje ćemo predložiti i istražiti supersimetrični matrični model dualan nerelativističkoj M-teoriji. U 3 dimenzije konstruirat ćemo nerelativističke teorije supergravitacije s materijom van masene ljuske i koristiti ih za dobivanje nerelativističkih supersimetričnih teorija polja na zakrivljenim pozadinama. U relativističkom slučaju, potonji čine klasu teorija u kojima se očekivane vrijednosti pojedinih observabli mogu točno izračunati pomoću supersimetrične lokalizacije. Istražit ćemo vrijede li slični rezultati u nerelativističkom slučaju, posebice u supersimetričnim teorijama polja na zakrivljenim mnogostrukostima koje su nerelativistički analozi jednostavnih modela koji su se pojavili u studijama grafena.]]></summary_hr><summary_en><![CDATA[Motivated by potential applications to holography and non-perturbative aspects of quantum field theory, the project will construct novel non-relativistic supergravity theories in 10, 11 and 3 dimensions. To do this, we will use recent insights into Newton-Cartan geometry, a differential geometry framework to describe non-relativistic space-times, and its connection to Riemannian geometry via state-of-the-art non-relativistic limit procedures. In 10 and 11 dimensions, we will focus on maximal non-relativistic supergravity theories that can be viewed as low energy descriptions of non-relativistic string and M-theory. We will use these to study dualities and properties of p-branes in non-relativistic string theory. We will furthermore propose and investigate a supersymmetric matrix model dual of non-relativistic M-theory. In 3 dimensions, we will construct matter coupled, off-shell, non-relativistic supergravity theories and use them to obtain non-relativistic supersymmetric field theories on curved backgrounds. In the relativistic case, the latter form a class of theories in which expectation values of particular observables can be computed exactly using supersymmetric localization. We will investigate whether similar results hold in the non-relativistic case, in particular in supersymmetric field theories on curved manifolds that are non-relativistic analogues of toy models that appeared in studies of graphene.]]></summary_en></project><project>
<id>15244</id><title_hr><![CDATA[Leukocitni metabolički biljezi u kroničnoj limfocitnoj leukemiji prostorno razlučeni slikovnom spektrometrijom masa]]></title_hr><title_en><![CDATA[Leukocyte Metabolic Markers in Chronic Lymphocytic Leukemia Spatially Resolved by the Imaging Mass Spectrometry]]></title_en><user_id>5248</user_id><user_firstLast_name>Zeljko Debeljak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-8228</code><acronim><![CDATA[CLLaIMS]]></acronim><duration>31.12.2023 - 30.12.2027</duration><status>U tijeku</status><financ_value>129.670,20 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Clinical sciences, </scie_field_en><institution_hr><![CDATA[Klinički bolnički centar Osijek]]></institution_hr><institution_en><![CDATA[Clinical Medical Center Osijek]]></institution_en><team_members_id>19620, 4473, 7245, 28206, 6307, 866622, 866620, 866621, 29048, </team_members_id><team_members_names><![CDATA[Barbara Vuković, Stefan Mrđenović, Jasmina  Rajc, Dario Mandić, Vatroslav Šerić, Ana Kotris, Maja Lukić, Ivana Marković Marković, Iva Lukić, ]]></team_members_names><keywords_hr><![CDATA[KLL, Metabolizam, Spektrometrija masa, Krv, Ibrutinib]]></keywords_hr><keywords_en><![CDATA[CLL, Metabolism, Mass spectrometry, Blood, Ibrutinib]]></keywords_en><summary_hr><![CDATA[Uvod: Progresija kronične limfocitne leukemije (KLL) i njene komplikacije su povezane s promjenama broja i gubitkom funkcije krvnih stanica kojima prethode promjene u staničnom metabolizmu. Zahvaljujući visokoj prostornoj razlučivosti novi slikovni spektrometri masa (SSM) omogućavaju utvrđivanje prisustva različitih metabolita u pojedinačnim stanicama. Određivanje udjela stanica, prisutnih u razmazu krvi, koje sadrže mjerljive količine metaboličkih biljega povezanih s apoptozom ili autofagijom, bi moglo reflektirati učinak terapije ili vjerojatnost pojava komplikacija KLL.Hipoteza: Promjene sadržaja metaboličkih biljega u pojedinim leukocitnim lozama određene SSM koje prethode promjeni broja stanica su povezane s progresijom KLL, izostankom odgovora na terapiju ibrutinibom i njenim nuspojavama.Metode: Kliničkoj evaluaciji povezanosti metaboličkih leukocitnih biljega s tijekom i liječenjem KLL prethodit će prilagodba SSM tehnologije za snimanje krvnih razmaza. Na temelju masenih spekatara (MS) krvnih stanica će biti odabrani metabolički biljezi čiji su signali u MS dovoljno reproducibilni za dijagnostičku ili prognostičku primjenu a koji su, ujedno, povezani s autofagijom, apoptozom i sl. Uslijediti će klinička opservacijska istraživanja povezanosti promjena udjela stanica određene loze koje ispoljavaju ciljane metaboličke biljege sa progresijom bolesti, sa odgovorom na monoterapiju ibrutinibom te sa nuspojavama te terapije. Dobiveni rezultati će se usporediti sa svojstvima rutinskih dijagnostičkih i prognostičkih pokazatelja.Učinci: Prognostička primjena leukocitnih metaboličkih biljega prostorno razlučenih SSM bi mogla omogućiti rano prepoznavanje promjena tijeka KLL i komplikacija a pronalaženje kandidata za prognostičku primjenu iz grupe metaboličkih biljega povezanih s apoptozom i autofagijom bi dalo novi uvid u patofiziologiju i farmakoterapiju KLL.]]></summary_hr><summary_en><![CDATA[Introduction: The progression of chronic lymphocytic leukemia (CLL) and its complications are associated with changes in the number and loss of function of blood cells, which are preceded by changes in cellular metabolism. Thanks to the high spatial resolution, new imaging mass spectrometers (IMS) make it possible to determine the presence of different metabolites in individual cells. Determining the fraction of cells, present in the blood smear, that contain measurable amounts of metabolic markers associated with apoptosis or autophagy, could reflect the effect of therapy or the likelihood of CLL complications.Hypothesis: Changes in the content of metabolic markers in certain leukocyte lineages determined by IMS, which precede the change in the number of cells, are associated with the progression of CLL, lack of response to ibrutinib therapy and its side effects.Methods: The clinical assessment of the association between metabolic leukocyte markers and the course or the treatment of CLL will be preceded by the adaptation of IMS. On the basis of blood cells&#39; mass spectra (MS), metabolic markers will be selected whose signals in MS are sufficiently reproducible for diagnostic or prognostic use and which, at the same time, are associated with autophagy, apoptosis, etc. After that, clinical observational studies of association between the fraction of cells exhibiting targeted metabolic markers and disease progression, response to ibrutinib monotherapy, and side effects of that therapy will be conducted. The obtained results will be compared with the properties of routine diagnostic and prognostic indicators.Outputs: Prognostic application of leukocyte metabolic markers spatially resolved by IMS could enable early identification of CLL course changes and complications, and finding candidates for prognostic application from the group of metabolic markers associated with apoptosis and autophagy would provide new insight into the pathophysiology and pharmacotherapy of CLL.]]></summary_en></project><project>
<id>15245</id><title_hr><![CDATA[Nove teme u hrvatskoj filozofiji od 1874. do 1945. godine]]></title_hr><title_en><![CDATA[New Topics in Croatian Philosophy from 1874 to 1945]]></title_en><user_id>2634</user_id><user_firstLast_name>Ivana Skuhala Karasman</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-5438</code><acronim><![CDATA[CroPhil]]></acronim><duration>18.12.2023 - 17.12.2027</duration><status>U tijeku</status><financ_value>105.647,36 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filozofija, </scie_field_hr><scie_field_en>Philosophy, </scie_field_en><institution_hr><![CDATA[Institut za filozofiju]]></institution_hr><institution_en><![CDATA[Institute for Philosophy in Zagreb]]></institution_en><team_members_id>3152, 29101, 858392, 3206, 865617, 20134, 865642, 12548, 3345, 865618, </team_members_id><team_members_names><![CDATA[Luka Boršić, Alojz Čubelić, Ana Grgić, Boris Kožnjak, Ivan Macut, Bojan Marotti, Bruno Matos, Petar Šegedin, Dario Škarica, Draženko Tomić, ]]></team_members_names><keywords_hr><![CDATA[hrvatska filozofija, povijest psihologije, odgoj, estetika, feministička filozofija, nacionalna filozofija]]></keywords_hr><keywords_en><![CDATA[Croatian philosophy, history of psychology, education, aesthetics, feminist philosophy, national philosophy]]></keywords_en><summary_hr><![CDATA[Dosad objavljeni rezultati predstavljaju dobru podlogu za daljnja istraživanja hrvatske filozofije između 1874. i 1945. godine, no ne daju cjelovitu sliku. U projektu će se obraditi teme koje nisu bile predmetom ni istraživanja ni valoriziranja. Početak je 1874. godina kad je osnovano moderno Sveučilište u Zagrebu i kad je s radom započeo Mudroslovni (današnji Filozofski) fakultet u čijem je sastavu djelovala i katedra za filozofiju na kojoj su predavali filozofi koji su zaslužni za razvoj moderne filozofske misli u nas. Tad se javljaju prve filozofkinje u Hrvatskoj (Kučera, Rossi, Ebenspanger) koje su u svojim radovima pratile trenove u europskim filozofskim kretanjima. Godina s kojom završava projekt jest 1945. kada u središte proučavanja i podučavanja dolazi marksistička filozofija s čime započinje nova era u filozofskom životu Hrvatske. Premda se radi o kratkom razdoblju od 71 godine u kojem su se na malom prostoru vjerojatno svi filozofi međusobno poznavali i komunicirali, ipak je vladala raznolikost filozofskih pristupa i škola. Ističu se: novoskolastika, utjecaj razvoja prirodnih i društvenih znanosti, a posebice psihologije na filozofiju, novokantovstvo, herbartizm i njemački idealizam. Svakako je važno naglasiti da se u to doba počinje sustavno stvarati filozofija na hrvatskom jeziku što je prije toga bila rijetkost. Paralelno s time počinje se razvijati i hrvatska znanstveno-filozofska terminologija. Unutar projekta istražit ćemo osam dosad neobrađenih tema: 1. filozofsko-odgojne teme; 2. odnos psihologije i filozofije; 3. počeci feminističke filozofije među hrvatskim filozofkinjama i intelektualkama; 4. estetičke teme; 5. spoznajna teorija kod Hijacinta Boškovića; 6. metafizika Gjure Arnolda; 7. Zimmermannova etika i noetika; 8. polemika između Krune Krstića i Stjepana Zimmermanna.]]></summary_hr><summary_en><![CDATA[The results published so far represent a good basis for further research into Croatian philosophy between 1874 and 1945, but they do not give a complete picture. The project will deal with topics that were not the subject of either research or evaluation. The beginning is year 1874, when the modern University of Zagreb was founded and when the Faculty of Humanities and Social Sciences began its work, which also included the department of philosophy, where philosophers meritorious for the development of modern philosophy in our country taught. In that time first female philosophers in Croatia started working (Kučera, Rossi, Ebenspanger) who in their works followed trends in European philosophical movements. The year with which the project ends is 1945, when Marxist philosophy enters the centre of study and teaching, which marks the beginning of a new era in the philosophical life of Croatia. Although it is a short period of 71 years in which all philosophers probably knew and communicated with each other in a small space, there was still a diversity of philosophical approaches and schools. They stand out: New Scholasticism, the influence of the development of natural and social sciences, and especially psychology on philosophy, Neo-Kantism, Herbartism and German idealism. It is important to emphasize that philosophy began to be systematically created in the Croatian language at that time, which was a rarity before that. In parallel with that, Croatian scientific and philosophical terminology began to develop. Within the project, we will explore eight previously unaddressed topics: 1. philosophical-educational topics; 2. the relationship between psychology and philosophy; 3. the beginnings of feminist philosophy among Croatian female philosophers and intellectuals; 4. aesthetic themes; 5. cognitive theory by Hijacint Bošković; 6. Gjuro Arnold&#39;s metaphysics; 7. Zimmermann&#39;s ethics and noetics; 8. controversy between Kruno Krstić and Stjepan Zimmermann.]]></summary_en></project><project>
<id>15246</id><title_hr><![CDATA[Međudjelovanje heterozigotne mutacije gena za ribosomski protein L24 i p53 u patogenezi bolesti]]></title_hr><title_en><![CDATA[Interplay between ribosomal protein L24 heterozygosity and p53 in disease pathogenesis]]></title_en><user_id>7705</user_id><user_firstLast_name>Siniša Volarević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-9967</code><acronim><![CDATA[RIBO-PATH]]></acronim><duration>27.12.2023 - 26.12.2027</duration><status>U tijeku</status><financ_value>199.084,20 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Medicine]]></institution_en><team_members_id>865200, 865960, 865964, 1435, 866141, 866140, 20620, </team_members_id><team_members_names><![CDATA[Katarina Budić, Miljana Uzelac-Šćiran, Ivana Matušić, Katarina Vilović, Jiri Bartek, Stefano Fumagalii, Mikael Lindstrom, ]]></team_members_names><keywords_hr><![CDATA[Ribosomski proteini, p53, ribosomopatije, mTORC1, patogeneza raka]]></keywords_hr><keywords_en><![CDATA[Ribosomal proteins, p53, ribosomopathies, mTORC1, cancer pathogenesis]]></keywords_en><summary_hr><![CDATA[Glavni cilj naših istraživanja otkriti je mehanizme nastanka ribosomopatija, bolesti u ljudi uzrokovanih mutacijama u genima za ribosomske proteine (RP) ili faktore sinteze ribosoma. Pogreške u sintezi ribosoma aktiviraju supresor tumora p53. Dokazali smo da je p53 aktiviran u specifičnim tkivima miševa heterozigotnih za Rpl24 (Rpl24+/-) te da uzrokuje njihov morfološki patološki fenotip. Iznenađujuće, u odsutnosti p53 većina tih miševa ugiba neposredno nakon okota. Međutim, mehanizmi putem kojih međudjelovanje mutacije Rpl24+/- i p53 uzrokuje specifične fenotipove nepoznati su. Naši preliminarni rezultati ukazuju na povezanost gubitaka p53 u MEF-ovima Rpl24+/- s ubrzanjem njihove diobe i sinteze proteina te povećanjem količine agregata proteina. Te promjene pozitivno koreliraju s aktivnošću mTORC1 kinaze. Pretpostavljamo da se poremećaj homeostaze proteina i oksidacijski stres u Rpl24+/- miševa pogoršava uslijed gubitka p53 zbog nemogućnosti inhibicije mTORC1-ovisne sinteze proteina i aktivacije mTORC1-ovisne autofagije te da se te promjene dodatno intenziviraju u uvjetima fiziološkog gladovanja i oksidacijskog stresa na okotu, što rezultira njihovim ugibanjem. U svrhu testiranja hipoteze, odredit ćemo učinke mutacije Rpl24+/- u prisutnosti ili odsutnosti p53 na količinu ribosoma, homeostazu proteina, oksidacijski stres i transkriptom u MEF-ovima. Dobiveni rezultati ukazat će na molekularne promjene u tek okoćenih Rpl24+/-:p53-/- miševa koje ćemo modulirati upotrebom specifičnih farmakoloških spojeva s ciljem sprječavanja njihovog ugibanja. Osim toga, otkrića u ovom projektu osigurat će smjerokaz za buduća istraživanja ribosomopatija i zloćudnih tumora uzrokovanih pogreškama u sintezi ribosoma, što može rezultirati otkrićem novih ciljeva za razvoj lijekova za te bolesti.  Rezultati projekta i suradnja s vrhunskim znanstvenicima u području ribosomopatija, p53 i raka povećat će kapacitet za istraživanja i obrazovanje mladih znanstvenika u Rijeci.]]></summary_hr><summary_en><![CDATA[The focus of our research is to gain insights into the mechanisms underlying ribosomopathies, diseases caused by mutations in genes encoding some ribosomal proteins (RPs) or ribosome biogenesis factors. Perturbation of ribosome biogenesis activates the p53 tumor suppressor. We previously showed that p53 activation is responsible for the morphological phenotypes of Rpl24+/- mice and surprisingly also promotion of their neonatal survival. However, the underlying mechanisms by which the interplay between Rpl24+/- mutation and p53 activity determines phenotypic outcomes are unknown. Our preliminary results suggest that p53 loss in Rpl24+/- MEFs not only accelerates their proliferation and protein synthesis rate but also aggravates their intrinsic proteotoxic stress. These changes positively correlate with mTORC1 activity. We hypothesize that in Rpl24+/-:p53-/- mice elevated intrinsic proteotoxic and oxidative stress, and the inability to downregulate protein synthesis and upregulate autophagy due to high mTORC1 activity, are vulnerabilities that are further exacerbated by physiological nutrient starvation and oxidative stress at birth, leading to neonatal lethality. To test the hypothesis, and with an eye on potential therapeutic exploitation of the subsequent molecular insights, we will assess the impact of Rpl24 heterozygosity in the presence or absence of p53 on ribosome abundance and function, protein homeostasis, redox balance, and transcription output. We will also identify molecular vulnerabilities of Rpl24+/-:p53-/- neonates and exploit them pharmacologically to try to rescue lethality. This study will provide the foundation for future studies of ribosomopathies, particularly cancers associated with these diseases, which may reveal new therapeutic targets. The project should improve the research capacity and education of young scientists in Rijeka, with collaboration with experts in the field of ribosomopathies and cancer contributing additional benefits.]]></summary_en></project><project>
<id>15247</id><title_hr><![CDATA[NUMERIČKA SINTEZA 3D OBLIKA S NAPREDNIM PARAMETRIZACIJAMA GEOMETRIJE, EKSPERIMENTALNA  VALIDACIJA I POVRATNA PRILAGODBA NUMERIČKIH MODELA]]></title_hr><title_en><![CDATA[NUMERICAL 3D SHAPE SYNTHESIS WITH ADVANCED GEOMETRY PARAMETERIZATION, EXPERIMENTAL VALIDATION AND FEEDBACK-BASED TUNING OF NUMERICAL MODEL]]></title_en><user_id>13265</user_id><user_firstLast_name>Ivo Marinić-Kragić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-8856</code><acronim><![CDATA[Num3DEx]]></acronim><duration>18.12.2023 - 17.12.2027</duration><status>U tijeku</status><financ_value>140.000,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Temeljne tehničke znanosti, Strojarstvo, </scie_field_hr><scie_field_en>Basic engineering sciences, Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Fakultet elektrotehnike, strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Electrical Engineering, Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>866365, 13396, 4871, 3851, 4969, 5150, 4873, 4983, </team_members_id><team_members_names><![CDATA[Domagoj Samardžić, Milan Ćurković, Ivan Tomac, Damir Vučina, Igor Pehnec, Željan Lozina, Damir Sedlar, Zoran Milas, ]]></team_members_names><keywords_hr><![CDATA[Numerička optimizacija, Multidisciplinarna optimizacija, Eksperimentalna mehanika fluida, Vjetroturbine s vertikalnom osi, Parametrizacija geometrije]]></keywords_hr><keywords_en><![CDATA[Numerical optimization, Multidisciplinary optimization, Experimental fluid mechanics, Vertical axis wind turbines, Shape parameterization]]></keywords_en><summary_hr><![CDATA[Projekt se nastavlja na dva prethodna HRZZ projekta (HRZZ-IP-2014-09-6130 i HRZZ-IP-2018-01-6774) koja su rezultirala s ukupno 19 publikacija u prestižnim znanstvenim časopisima. Cilj projekta je razvoj metoda za numeričku optimizaciju 3D oblika s spregnutim prilagođavanjem numeričkog modela na temelju eksperimentalnih podataka. Utjecaj ove povratne petlje na dobivena rješenja će uvelike ovisiti o kvaliteti i broju eksperimenata, zbog čega se veliki dio projekta odnosi na izrade prototipova i njihovo ispitivanje. Ispitivanja se planiraju na vjetroturbinama s vertikalnom osi u postojećem ad-hoc aerodinamičkom tunelu, ali razmatrat će se i drugi inženjerski problemi. Projekt uključuje:- za rezultate iz prethodnih numeričkih optimizacija za vjetroturbine s vertikalnom osi, eksperimentalno određivanje koeficijenta snage korištenjem 3D printanih modela te postojećeg aerodinamičkog tunela - razvoj metoda parametrizacija oblika iz skupa dosadašnjih geometrija, uz prilagođavanje tehnologiji izrade, posebno za 3D tehnologiju- razvoj metoda za eksperimentalno ispitivanje lokalnih značajki strujanja (npr. brzina, tlak, i intenzitet turbulencije) u svrhu prilagođavanja numeričkog modela.- eksperimentalno mjerenje buke i vibracija za odabrane inženjerske probleme- multidisciplinarna numerička analiza (strujanje fluida, strukturna mehanika, proizvedena električna energija) i optimizacija za vjetroturbine s vertikalnom osi- izrada eksperimentalnih prototipova koji su prilagođeni za transport i testiranje u realnim uvjetima ili transport u aerodinamički tunel u druge institucije- evaluacija različitih numeričkih modela strujanja s obzirom na eksperimentalne podatke i određivanje potrebnih parametara za prilagođavanje- primjena razvijenih numeričkih i eksperimentalnih procedura na različitim inženjerskim primjerima što uključuje i druge tipove vjetroturbina, metode hlađenja fotonaponskih panela te hibridne sustave.]]></summary_hr><summary_en><![CDATA[Project is continuation of two previous HRZZ projects (HRZZ-IP-2014-09-6130 and HRZZ-IP-2018-01-6774) which have resulted in 19 publications in prestigious scientific journals. The objective of the project is to develop methods for numerical optimization of 3D shape coupled with numerical model tuning based on experimental data. The effect of this feedback loop will depend on the quality and the number of performed experiments, so a large part of the project is related to developing physical prototypes and their testing. The experiments are planned for vertical axis wind turbines (VAWTs) in the existing ad-hoc wind tunnel, but other engineering problems will also be considered. Project includes: - for the results from previous numerical optimizations for VAWTs, experimental determination of the power coefficient using 3D printed models and the existing ad-hoc wind tunnel - development of shape parameterization methods from the currently available geometries with adaption to specific construction technologies, especially for 3D print technology - development of methods for experimental investigation of local flow variables (speed, pressure and/or turbulence intensity) with objective for further tuning of the numerical model - experimental measurement of noise and vibrations for selected engineering problems - multidisciplinary numerical analysis (fluid flow, structural mechanic, electric power production) and optimization for VAWT. - constructing experimental prototypes adapted for transport and testing in real-life conditions or transport to wind tunnel in another institution- evaluation of different numerical flow model considering experimental data, and determination of required tuning parameters- application of the developed numerical and experimental procedures on different engineering examples which includes wind turbines, cooling methods for photovoltaic panels and hybrid systems.]]></summary_en></project><project>
<id>15249</id><title_hr><![CDATA[Uloga onkoproteina E6 u HPV-posredovanoj onkogenezi]]></title_hr><title_en><![CDATA[The Role of E6 Oncoprotein in HPV-mediated Oncogenesis]]></title_en><user_id>15915</user_id><user_firstLast_name>Vjekoslav Tomaic</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-7519</code><acronim><![CDATA[HPV-E6-ONCO]]></acronim><duration>31.12.2023 - 30.12.2027</duration><status>U tijeku</status><financ_value>197.049,57 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>17772, 25278, 24996, 2896, 572, 2507, 865814, 19200, 19310, 869789, 869827, 869858, </team_members_id><team_members_names><![CDATA[Josipa Skelin, Lucija Lulić, Anamaria Đukić, Robert Belužić, Magdalena Grce , Antonia Jakovčević, Joanna Parish, Miranda Thomas, Lawrence Banks, Katarina Soža, Toni Rendulić, Boon Shi, ]]></team_members_names><keywords_hr><![CDATA[HPV, E6, cervical cancer, prognostički biljezi, onkogeneza]]></keywords_hr><keywords_en><![CDATA[HPV, E6, cervical cancer, predictive markers, oncogenesis]]></keywords_en><summary_hr><![CDATA[Papiloma virusi čovjeka (eng. Human papillomaviruses, HPVs) odgovorni su za približno 5% karcinoma kod ljudi, pri čemu je glavna bolest rak vrata maternice. Tijekom perzistentne virusne infekcije, iz za sada nepoznatih razloga, životni ciklus HPV-a kolabira i virusni genomi se nasumično integriraju u kromosome domaćina, što uzrokuje nekontroliranu ekspresiju virusnih onkoproteina, E6 i E7, čije djelovanje dovodi do stanične transformacije. I A- i ß-E6 onkoproteini imaju LXXLL vezni motiv, preko kojeg A-E6s stupaju u interakciju s E6AP, a ß-E6s vežu MAML1. Obje interakcije su ključne za produktivni ciklus virusa i karcinogenezu posredovanu HPV-om. Naši preliminarni podaci sugeriraju da A-E6 također vežu MAML1, što dovodi do stabilizacije proteina E6 na način neovisan o E6AP i utječe na staničnu distribuciju E6, što rezultira povećanom proliferativnom i migracijskom sposobnošću HPV-18-pozitivnih HeLa stanica. Ovo sugerira da interakcija s MAML1 ima širi utjecaj na zloćudne bolesti izazvane HPV-om i otvara nove puteve istraživanja koja mogu dati vrijedne informacije o funkcijama E6 i njegovoj ulozi u modulaciji različitih staničnih signalnih putova.Cilj nam je istražiti kako onkogeni E6, u kompleksu s MAML1, može modulirati Notch signalizaciju te odrediti biološke posljedice ovog procesa. Naši će pristupi biti pronaći interakcijske partnere kompleksa HR E6/MAML1, analizirati biokemiju E6 regulacije Notch signalizacije putem MAML1 i povezati ove procese sa produktivnim ciklusom virusa i tumorigenezom izazvanom HPV-om.Ovaj će projekt pružiti važne informacije koje će pomoći u daljnjem razjašnjavanju osnovne biologije HPV-a i kako to utječe na HPV-om induciranu onkogenezu. Rezultati će odrediti može li ciljanje kompleksa E6/MAML1 i njegovih partnera imati ikakav terapeutski potencijal u patogenezi prosredovanoj HPV-om. Nadalje, oni će pružiti popis staničnih supstrata koji bi mogli djelovati kao potencijalni prediktivni markeri za HPV-om uzrokovane maligne bolesti.]]></summary_hr><summary_en><![CDATA[Human papillomaviruses (HPVs) are responsible for approximately 5% of human cancers, with cervical cancer being the principal disease. During persistent viral infection, for, as yet, unknown reasons, HPV life cycle collapses and viral genomes are randomly integrated into host chromosomes, leading to the uncontrolled expression of the viral oncoproteins, E6 and E7, whose activities lead to cellular transformation. Both A- and ß-E6 oncoproteins have an LXXLL binding motif, through which A-E6s interact with E6AP and ß-E6s bind MAML1. Both interactions are critical for the viral life cycle and HPV-mediated carcinogenesis. Our preliminary data suggest that A-E6s also bind MAML1, stabilising E6 protein in an E6AP-independent manner and affecting E6’s cellular distribution, resulting in increased proliferative and migratory capacity of HPV-18-positive HeLa cells. This suggests that the MAML1 interaction has a broader impact on HPV-induced malignancies, and opens new avenues of research that may give valuable information on E6 functions and involvement in modulating various cellular signalling pathways.We aim to investigate how cancer-causing E6, complexed with MAML1, can modulate Notch signaling and to determine the biological consequences of this process. Our approaches will be to find novel interacting partners of the HR E6/MAML1 complex, to analyse the biochemistry of E6’s regulation of Notch signaling via MAML1, and to link these processes to the viral life cycle and HPV-driven tumorigenesis.This project will provide important information that will help in further clarifying the basic biology of HPVs and how this affects HPV-induced oncogenesis. The results will determine if targeting the E6/MAML1 complex and its interactors might have any therapeutic potential in HPV-induced pathogenesis. Furthermore, they will provide a list of cellular substrates that could act as potential predictive markers for HPV-induced malignancies.]]></summary_en></project><project>
<id>15251</id><title_hr><![CDATA[Alternativno prekrajanje gena BPM2 kao mehanizam uspostave funkcionalne raznolikosti porodice proteina MATH-BTB u uročnjaku Arabidopsis thaliana]]></title_hr><title_en><![CDATA[Alternative splicing of BPM2 as a mechanism for establishing a functional diversity of MATH-BTB protein family in Arabidopsis thaliana]]></title_en><user_id>4217</user_id><user_firstLast_name>Nataša Bauer</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-7874</code><acronim><![CDATA[SpliceFun]]></acronim><duration>15.12.2023 - 14.12.2027</duration><status>U tijeku</status><financ_value>199.084,21 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>3746, 3735, 4614, 19214, 28868, 866019, 869770, 25016, 872931, 873053, </team_members_id><team_members_names><![CDATA[Dunja Leljak-Levanić, Nenad Malenica, Petra Cvjetko, Željka Vidaković-Cifrek, Sandra Vitko, Bernard Jarić, Gaj Keresteš, Mateja Jagić, Emma Stepinac, Klara Uhrl, ]]></team_members_names><keywords_hr><![CDATA[alternativno prekrajanje transkripata, BPM2, ekspresija gena, embriogeneza, MATH-BTB, proteinske interakcije, razvoj biljaka, stres, temperatura]]></keywords_hr><keywords_en><![CDATA[alternative splicing, BPM2, embryogenesis, gene expression, MATH-BTB, plant development, protein interactions, stress, temperature]]></keywords_en><summary_hr><![CDATA[Funkcionalna karakterizacija nekoliko članova porodice proteina MATH-BTB razotkrila je njihovu ulogu u širokom spektru važnih bioloških procesa, od regulacije stanične diobe, segregacije kromosoma u reproduktivnom razvoju i embriogenezi, do globalne kontrole metilacije DNA i regulacije transkripcije. Zanimljiva značajka porodice je ekspanzija članova u travama, kod kojih većina MATH-BTB gena ne sadrži introne. Nasuprot tome, samo šest MATH-BTB gena (BPM1-6) uročnjaka sadrži introne te neki od njih kodiraju nekoliko alternativnih varijanti transkripata te eventualno i proteina s potencijalno različitim funkcijama. Ciljevi ovog projekta su identifikacija novih varijanti alternativnog prekrajanja gena BPM2, specifičnih za različita tkiva/razvojne faze i temperature okoliša te njihova funkcionalna karakterizacija na temelju identifikacije proteinskih partnera. Nadalje, najunikatnija varijanta transkripta bit će odabrana za identifikaciju specifičnih partnerskih proteina koji će ukazati na moguće nove biološke funkcija gena BPM2 i porodice MATH-BTB, općenito.]]></summary_hr><summary_en><![CDATA[Functional characterization of few members of MATH-BTB protein family revealed their roles in a wide spectrum of essential biological processes, from regulation of cell division, chromosome segregation in reproductive development and embryogenesis, to global control of DNA methylation and regulation of transcription. The interesting feature of the family is expansion of members in grasses in which most of the MATH-BTB genes contain no introns. In contrast, the six MATH-BTB genes (BPM1-6) in Arabidopsis contain introns and encode up to five splice variants per gene, resulting in proteins with potentially different functions. The goals of the project are identification of new splice variants of BPM2, specific for different tissues/developmental stages and environmental temperatures, and functional characterization of selected BPM2 protein isoforms based on their protein partners. Moreover, a unique splicing variant will be selected for identification of its specific partner proteins, which will point to possible new functions of BPM2 and the MATH-BTB family in general.]]></summary_en></project><project>
<id>15252</id><title_hr><![CDATA[Ranonovovjekovni latinski kameni natpisi u crkvama južne Istre: dokumentacija, analiza, kontekstualizacija]]></title_hr><title_en><![CDATA[Early modern Latin lapidary inscriptions in the churches of southern Istria: documentation, analysis, contextualisation]]></title_en><user_id>4860</user_id><user_firstLast_name>Šime Demo</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-5068</code><acronim><![CDATA[LAPIS]]></acronim><duration>31.12.2023 - 30.12.2027</duration><status>U tijeku</status><financ_value>76.199,33 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Povijest, Filologija, Povijest umjetnosti, Arheologija, </scie_field_hr><scie_field_en>History, Philology, Art history, Archeology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet hrvatskih studija]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Croatian Studies]]></institution_en><team_members_id>865586, 6151, 5985, 6897, 865681, 6145, 28926, </team_members_id><team_members_names><![CDATA[Aleksandra Mahić Sinovčić, Mirjana Matijević Sokol, Sunčica Mustač, Darko Komšo, Milena Joksimović, Tomislav Galović, Josip Banić, ]]></team_members_names><keywords_hr><![CDATA[epigrafija – rani novi vijek, kameni natpisi – crkve, latinski jezik, povijest Istre – rani novi vijek, južna Istra – crkve]]></keywords_hr><keywords_en><![CDATA[epigraphy – Early Modern Period, lapidary inscriptions – churches, Latin language, history of Istria – Early Modern Period, southern Istria – churches]]></keywords_en><summary_hr><![CDATA[Slijedom činjenice da je epigrafska produkcija ranoga novog vijeka kudikamo slabije istražena od antičke i srednjovjekovne, ovo je istraživanje zamišljeno kao projekt sustavne dokumentacije i analize te inicijalne kontekstualizacije ranonovovjekovnih kamenih latinskih natpisa koji se nalaze u crkvama južne Istre. Procjenjujemo da se u 183 sakralna objekta na navedenome području nalazi 300–400 natpisa nastalih između 1420. i 1797. znatne povijesne, kulturne, književne i umjetničke vrijednosti, što je procijenjeno kao optimalna količina za obradu u okviru četverogodišnjega projekta. Dokumentacija predmetne građe načinit će se na temelju tromjesečnoga terenskog istraživanja, a transkripcije, fotografije, prijevodi, osnovni opis i literatura unijet će se u slobodno dostupnu i pretraživu bazu podataka uspostavljenu na početku projekta. Ta će baza biti osnova za izradu monografskoga kataloga natpisa. Analitička će se dionica projekta provesti kroz niz diseminacijskih studija o materijalnim, epigrafsko-paleografskim, filološko-jezičnim, književno-stilskim i povijesnoumjetničkim aspektima predmetnih natpisa. Konačno, kroz članke i konferencijska priopćenja naznačit ćemo perspektive kontekstualizacije epigrafske baštine u sklopu povijesti mjesne crkve, političke i privatne povijesti te glagoljske tradicije. Rad na projektu i njegovi rezultati prezentirat će se stručnoj zajednici kroz javno predstavljanje baze podataka i organizaciju projektne konferencije, studentima povijesti kroz studentsku radionicu, a široj javnosti kroz izložbu fotografija odabranih natpisa. Projekt će rezultirati znatnim obogaćenjem spoznaja o povijesti južne Istre u ranome novom vijeku, a u metodološkom smislu može postati polazištem za epigrafska istraživanja na drugim vrstama objekata, područjima i jezicima.]]></summary_hr><summary_en><![CDATA[Since early modern epigraphic production is much less researched than the ancient and medieval ones, this reaearch is designed as a project of comprehensive documentation and analysis, as well as initial contextualisation of early modern Latin lapidary inscriptions found in the churches of southern Istria. We estimate that in 183 sacred buildings in the area between 300 and 400 inscriptions made between 1420 and 1797 are found, having a significant historical, cultural, literary and artistic value; this has been estimated as an optimal quantity for a four-year project. Documentation of the inscriptions will be performed on the basis of a three-month field research, while the transcriptions, photographs, translations, basic descriptions and literature will be recorded in an open and searchable database established at the start of the project. This database will serve as the foundation of an inscripiton catalogue to be published in the form of a monograph. Analytical stage of the project will be organised through a series of dissemination studies on material, epigraphic-palaeographic, philologic-linguistic, literary-stylistic and art-historical aspects of the inscriptions. Finally, through articles and conference papers, we will indicate the perspectives of contextualisation of epigraphic heritage in the context of the local ecclesiastical history, political and private history, and glagolitic tradition. Work on the project and its results will be presented to the professional audience through a public presentation of the database and organisation of a project conference, to the history students through a workshop, and to general audience through an exhibition of the photographs of selected inscriptions. The project will result in a significant enrichment of our knowledge about the history of early modern southern Istria, while in the methodological sense it can serve as a basis for epigraphic research of other types of buildings, areas and languages. ]]></summary_en></project><project>
<id>15254</id><title_hr><![CDATA[Analiza parcijalnih diferencijalnih jednadžbi i optimizacija oblika]]></title_hr><title_en><![CDATA[Analysis of partial differential equations and shape optimization]]></title_en><user_id>628</user_id><user_firstLast_name>Marko Vrdoljak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-7261</code><acronim><![CDATA[ADESO]]></acronim><duration>15.12.2023 - 14.12.2027</duration><status>U tijeku</status><financ_value>181.252,90 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>72, 25426, 637, 865388, 23677, 864981, 866201, 17819, 872582, </team_members_id><team_members_names><![CDATA[Marko Erceg, Matko Grbac, Ivan Ivec, Milosz Krupski, Petar Kunštek, Sandeep Kumar Soni, Charles Dapogny, Andrej Novak, Abhishek Balakrishna, ]]></team_members_names><keywords_hr><![CDATA[optimizacija oblika, parcijalne diferencijalne jednadžbe, derivacija oblika, nelokalne zadaće, obrada slika]]></keywords_hr><keywords_en><![CDATA[shape optimization, partial differential equations, shape differentiation, nonlocal problems, image processing]]></keywords_en><summary_hr><![CDATA[Cilj optimizacije oblika je smanjiti troškove i poboljšati performanse složenih sustava npr. smanjenja otpora zraka kod zrakoplova i automobila, povećanja krutosti ploča, smanjivanje težine radijatora, poboljšanja preciznosti u električnoj impendancijskoj tomografiji (EIT) ili procesu obrade slike. Optimizacija oblika se može interpretirati i kao dio teorije optimalnog upravljanja, ali težina problema je u tome što upravljačka varijabla nije skup funkcija i/ili parametara već struktura ili geometrijski oblik.  Standardno u optimizaciji oblika, funkcija culja ne ovisi izravno o geometrijskom obliku, već o nekim drugim varijablama sustava npr.  brzini fluida, deformaciji elastičnog tijela, temperaturi itd. Dane varijable su zapravo rješenja parcijalnih diferencijalnih jednadžbi. Iz tog razloga je potrebno je unaprijediti teorijski i numerički okvir za rješavanje parcijalnih diferencijalnih jednadžbi jer neki fenomeni nisu dobro opisani postojećim modelima pa će dio projekta biti posvećen proučavanja nelokalnih parcijalnih diferencijalnih jednažbi i općenitoj teoriji pseudodiferencijalnih operatora i primjena.  Jedan od važnijih ciljeva projekta je teorijski razvoj derivacije oblika s posebnim fokusom na probleme višestrukih stanja te probleme robusnosti modela. Proučavati će se  uvjeti optimalnosti prvog i drugog reda kod problema optimizacije oblika kako bi se razvili i unaprijedili postojeći numerički algoritmi zasnivani na derivaciji oblika. Analizom uvjeta optimalnosti prvog i drugog reda  pokušat će se objasniti nepredvidiva pojava lokalnih ekstrema. ]]></summary_hr><summary_en><![CDATA[The aim of shape optimization is to reduce the costs and improve the performance of complex systems, like reducing the drag of aircrafts, cars and boats, increasing the stiffness of plates, reducing the weight of radiators, but also improving the precision in electrical impedance tomography, or tackling some questions in image processing. It could be understood as a part of optimal control theory but the mathematical challenge lies in the fact that the control variable is no longer a set of functions and/or parameters, but the structure or shape of a geometric object. As it is common in optimal control, the goal functional does not only depend directly on the shape of considered objects, but also on the state of some shape-dependent quantities. These quantities might be the flow velocity, deformation of the elastic body, temperature distribution in the object etc. Typically, mathematical models for such quantities are given by partial differential equations. Therefore, a development of modelling techniques, analytical framework, and numerical methods for partial differential equations will be of the highest importance in this project. However, some phenomena are not well described by partial differential equations, and part of the project will be devoted to the study of nonlocal equations, or a more general framework of pseudodifferential operators, as well as some applications.An important goal of the project is further development of shape calculus, with particular attention paid to multiple state problems, resolving some robustness questions, and conducting uncertainty analysis.  The first and second order optimality conditions in shape optimization problems will be studied in order to achieve more efficient numerical algorithms, but also theoretically in a simplified  setting to encompass erratic occurrences of local extrema. ]]></summary_en></project><project>
<id>15261</id><title_hr><![CDATA[Kosti, izotopi i geni: zdravlje, prehrana i podrijetlo antičkih stanovnika Hrvatske]]></title_hr><title_en><![CDATA[Bones, isotopes and genes: Health, diet and ancestry of the Roman period inhabitants of Croatia]]></title_en><user_id>2670</user_id><user_firstLast_name>Mario Novak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-8558</code><acronim><![CDATA[AncientRomans]]></acronim><duration>18.12.2023 - 17.12.2027</duration><status>U tijeku</status><financ_value>114.840,00 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Arheologija, </scie_field_hr><scie_field_en>Archeology, </scie_field_en><institution_hr><![CDATA[Institut za antropologiju]]></institution_hr><institution_en><![CDATA[Institute for Anthropological Research]]></institution_en><team_members_id>24314, 866023, 2764, 865984, 866015, 866004, 869885, </team_members_id><team_members_names><![CDATA[Mario Carić, Anna Osterholtz, Ivor Janković, Hrvoje Vulić, Cosimo Posth, Timka Alihodžić, Barbara Kriletic, ]]></team_members_names><keywords_hr><![CDATA[Antika, Hrvatska, bioarheologija, trovanje olovom, rekonstrukcija prehrane, drevna DNA]]></keywords_hr><keywords_en><![CDATA[Roman period, Croatia, bioarchaeology, lead poisoning, diet reconstruction, ancient DNA]]></keywords_en><summary_hr><![CDATA[Razdoblje prevlasti Rimskog Carstva na području Europe i Mediterana jedno je od ključnih perioda u povijesnom razvoju ovog dijela svijeta. Strukturne političke, društvene i ekonomske promjene nastale vlašću Rimljana imale su izniman utjecaj na demografsku i populacijsku strukturu lokalnog stanovništva, uvođenje novih prehrambenih navika te pojavu i širenje zaraznih bolesti. Kako bi se dobila jasnija i detaljnija slika o navedenim procesima ovim projektom provest će se sveobuhvatno istraživanje ljudskih ostataka i materijalne kulture s deset antičkih nalazišta iz Hrvatske što uključuje arheološko-kronološku kontekstualizaciju, standardnu bioarheologiju, analizu stabilnih izotopa ugljika i dušika, analizu olova u organizmu te analizu drevne DNA i DNA patogena. Kroz navedeni projekt se po prvi puta sistematski istražuju antičke populacije s prostora Hrvatske na lokalnom i regionalnom nivou koristeći holistički pristup i najmodernije analitičke tehnike, a većina analiza provodi se u laboratorijima u Hrvatskoj. Predloženo istraživanje će iz temelja izmijeniti naše znanje o antičkim stanovnicima Hrvatske što predstavlja izniman korak naprijed u antičkoj arheologiji ne samo u Hrvatskoj već i u širem europskom i mediteranskom kontekstu.  ]]></summary_hr><summary_en><![CDATA[The period of dominance of the Roman Empire in Europe and the Mediterranean is one of the key epochs in the historical development of this part of the world. The structural political, social and economic changes caused by the Roman dominance had a significant impact on the demographic and population structure of the local populations, the changes in dietary habits and the occurrence and spread of infectious diseases. With the aim to obtain a clearer and more detailed picture of these processes this project will conduct a comprehensive study of human remains and material culture from ten Roman period sites from the territory of Croatia including archaeological-chronological contextualization, conventional bioarchaeology, carbon and nitrogen stable isotopes analysis, organism lead level analysis, and ancient DNA and pathogen DNA analyses. This project will for the first time systematically investigate Roman period populations from Croatia at the local and regional levels using a holistic approach and most advanced analytical techniques with most of the analyses carried out in laboratories in Croatia. The proposed study will fundamentally change our knowledge about the Roman period inhabitants of Croatia which represents a huge step forward in Roman period archaeology not only in Croatia, but also in the wider European and Mediterranean contexts.]]></summary_en></project><project>
<id>15264</id><title_hr><![CDATA[Latentna infekcija citomegalovirusom u središnjem živčanom sustavu]]></title_hr><title_en><![CDATA[Cytomegalovirus latency in the central nervous system   ]]></title_en><user_id>4834</user_id><user_firstLast_name>Ilija Brizić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-3371</code><acronim><![CDATA[CMV-CNS]]></acronim><duration>27.12.2023 - 26.12.2027</duration><status>U tijeku</status><financ_value>198.984,67 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Medicine]]></institution_en><team_members_id>11106, 861498, 857297, 868726, 869617, 25391, 23779, 873088, </team_members_id><team_members_names><![CDATA[Stipan Jonjić, Fran Krstanović, Andrea Mihalić, Lucija Šakota, Matko Tudor, Valentina Hribljan, Marija Mazor, Iva Vladić, ]]></team_members_names><keywords_hr><![CDATA[Citomegalovirus, prirođena infekcija, mikroglija, tkivno-rezidentni limfociti T, latencija, starenje ]]></keywords_hr><keywords_en><![CDATA[cytomegalovirus, congenital infection, microglia, tissue resident T cells, latency, aging]]></keywords_en><summary_hr><![CDATA[Mnogi virusi mogu uzrokovati trajne ili latentne infekcije i/ili upale u SŽS-u. Sve veći broj studija ukazuje da takve infekcije mogu uzrokovati različita patološka stanja i bolesti. Prirođena infekcija citomegalovirusom (CMV) glavni je uzrok transplacentarno prenosivih prirođenih infekcija i može uzrokovati širok raspon strukturnih i funkcionalnih oštećenja, te trajnih neuroloških posljedica. Naši preliminarni rezultati dobiveni upotrebom in vivo mišjeg modela prirođene infekcije CMV-om ukazuju da su neuroni mjesto latentne infekcije mišjim (M)CMV-om i mjesto reaktivacije, dok astrociti i mikroglija ne sadrže latentni virus. U latentno inficiranom središnjem živčanom sustavu (SŽS), limfociti T su doživotno zadržani u tkivu, te su potrebni za kontrolu MCMV-a. Nadalje, otkrili smo da je mikroglija trajno aktivirana u latentno inficiranom SŽS-u. Trenutno nije poznato kako limfociti T posreduju nadzor nad latentnom infekcijom u neuronima, te kako trajna aktivacija mikroglije doprinosi navedenim procesima. Osim toga, nije istražena sposobnost virusa koji reaktivira u neuronima da se širi na druge stanice. U ovom istraživanju ćemo odgovoriti na ta pitanja. Kako bi odredili može li se virus koji reaktivira u neuronima širiti na druge stanice, kultivirat ćemo latentno inficirane neurone sa stanicama prijemčljivim za MCMV i koristiti organotipski model kulture tkiva mozga. Kako bismo odredili ulogu aktivirane mikroglije u kontroli latentnog virusa, koristit ćemo različite pristupe za uklanjanje mikroglije, kao i inducibilne kondicionalne knock-out sojeve miševa za eliminaciju ključnih efektorskih molekula na mikrogliji. Na kraju, istražit ćemo strukturne i funkcionalne promjene mozga uzrokovane latentnom infekcijom CMV-om u mozgu tijekom starenja. Razumijevanje mehanizama oštećenja SŽS-a i otkrivanje mehanizama latentne infekcije ključno je za razvoj bolje terapije. Osim toga, ova će studija otvoriti nova istraživanja o latentnim virusnim infekcijama mozga.]]></summary_hr><summary_en><![CDATA[Many viruses can cause persistent or latent infections and/or inflammation in the CNS. Growing body of evidence suggests that such infections can cause wide array of pathologies and morbidities. Congenital cytomegalovirus (CMV) infection is a major cause of trans-placentally transmitted congenital infections and may cause a wide range of structural and functional disabilities and permanent neurological sequelae. Our preliminary data obtained using in vivo mouse model of congenital CMV infection shows that neurons are site of latent mouse (M)CMV infection and reactivation, while astrocytes and microglia do not carry latent virus. Latent MCMV infection in the CNS is associated with life-long retention of tissue-resident T cells which are required to control latent virus. Furthermore, we found that microglia is persistently activated in the latently infected CNS. It is not known which T cell mechanisms are required to control latent infection in neurons and how persistent activation of microglia contributes to these processes. In addition, the ability of virus reactivating in neurons to spread to other cells is not known. Here we will answer these questions. To assess if virus reactivating in neurons can spread to other cells we will cocultivate latently infected neurons with MCMV-susceptible cells, and use organotypic tissue culture model. To determine the role of activated microglia in control of latent virus, we will use microglia depletion approaches, as well as inducible conditional knockout mice to selectively eliminate key effector molecules of microglia. Finally, we will investigate brain structural and functional changes caused by latent CMV infection in the brain during aging. Understanding mechanisms of CNS damage and deciphering the mechanisms of latent infection, as well as associated immune response is crucial to develop better interventional therapy. In addition, this study will open new avenues of research of latent viral infections in brain.]]></summary_en></project><project>
<id>15268</id><title_hr><![CDATA[Otkrivanje mehanizama otpornosti melanoma na inhibitore BRAF/MEK]]></title_hr><title_en><![CDATA[Deciphering the mechanisms of resistance to BRAF/MEK inhibitors in melanoma]]></title_en><user_id>649</user_id><user_firstLast_name>Neda Slade</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-1375</code><acronim><![CDATA[REMEL]]></acronim><duration>30.12.2023 - 29.12.2027</duration><status>U tijeku</status><financ_value>189.755,00 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>4806, 1322, 26651, 1470, 7441, 866123, 2812, 869751, 25102, </team_members_id><team_members_names><![CDATA[Ignacija Vlašić, Anđela Horvat, Jean-Christophe Bourdon, Ivan Milas, Jasmina Marić Brozić, Luka  Simetić, Božena Šarčević, Janja Josić, Christine Supina Pavić, ]]></team_members_names><keywords_hr><![CDATA[melanom, izoforme obitelji p53, BRAF/MEK inhibitori, rezistencija na MAPK-ciljanu terapiju, p53, p63, p73]]></keywords_hr><keywords_en><![CDATA[melanoma, p53 family isoforms, BRAF/MEK inhibitors, resistance to MAPK targeted therapy, p53, p63, p73]]></keywords_en><summary_hr><![CDATA[Otkriće mutacije u genu BRAF kao pokretačke mutacije u melanomu omogućilo je razvoj ciljanih inhibitora koji su promijenili liječenje pacijenata oboljelih od melanoma. Kombinirana terapija ciljanjem kinaza BRAF i MEK je, uz imunoterapiju, uobičajeni terapijski pristup za pacijente koji posjeduju mutaciju BRAF p.V600E. Međutim, većina pacijenata razvija otpornost čiji temeljni molekulski mehanizmi još uvijek nisu u potpunosti razjašnjeni i predstavljaju veliki izazov u liječenju melanoma. U predloženom istraživanju planiramo uspostaviti stanične linije melanoma iz biopsija pacijenata otpornih na inhibitore kinaza BRAF/MEK i istražiti mehanizme uočene otpornosti. Podaci dobiveni s cBioPortala ukazuju na važnost prisutnosti mutacija u članovima obitelji p53 u melanomima (mutacije u TP53 i/ili TP63 se javljaju u približno 40% svih uzoraka melanoma) i posebno ih treba uzeti u obzir u BRAF-mutiranim tumorima u kojima se mutacije u TP53 i TP63 pojavljuju u 21,6%, odnosno 14,7% slučajeva. Štoviše, rezultati naših dosadašnjih istraživanja, kao i rada drugih grupa, ukazuju da bi promijenjena ekspresija i poremećaj regulacije izoformi obitelji p53 mogli pospješiti razvoj otpornosti na terapiju inhibitorima BRAF/MEK kod metastatskog melanoma. Shodno tome, nakon određivanja mutacijskog statusa, profila ekspresije i unutarstanične lokalizacije izoformi, kao i njihovih međusobnih interakcija, utvrdit ćemo funkcionalni odnos između članova obitelji p53. S ciljem određivanja uloge specifičnih izoformi obitelji p53 u melanomu otpornom na inhibitore BRAF/MEK, utišat ćemo ekspresiju izoformi i provesti različite biološke testove. Uvjereni smo da će predloženo istraživanje rasvijetliti molekulske mehanizme otpornosti stanica melanoma na inhibitore BRAF/MEK posredovane proteinom p53 i utvrditi specifičan obrazac ekspresije izoformi p53 obitelji koji bi mogao ukazivati na učinkovitost ciljane terapije te otkriti moguće terapijske ciljeve.]]></summary_hr><summary_en><![CDATA[The identification of BRAF as the driver mutation in melanoma enabled the development of targeted inhibitors that revolutionized the treatment of melanoma patients. In addition to immunotherapy, for patients harboring the BRAF p.V600E mutation the combined BRAF/MEK targeted therapy is a common therapeutic approach. However, the majority of patients develop resistance whose underlying molecular mechanisms are still not completely understood and, thus, remain a major challenge for melanoma treatment. In the proposed study, we plan to establish biopsy-derived melanoma cell lines resistant to BRAF/MEK inhibitors and to investigate the mechanisms of resistance. The data obtained from cBioPortal database indicate that the importance of mutated p53 family members (mutations in TP53 and/or TP63 occur in approximately 40% of melanoma samples) should be considered in BRAF mutated tumors where mutations in TP53 and TP63 occur in 21.6% and 14.7% cases, respectively. In addition, according to the previous studies by us and others, the altered expression and dysregulation of p53 family isoforms could promote the development of resistance to BRAF/MEK inhibitor therapy in metastatic melanoma. After acquiring the mutational status, expression profile and subcellular localization of isoforms as well as their mutual interactions, we will determine the functional relationship between the p53 family members. By knocking down specific group of p53 family isoforms and performing different bioassays we aim to determine their roles in BRAF/MEK inhibitor resistant melanoma. We are confident that the proposed research will decipher the molecular mechanisms of p53-driven resistance of melanoma cells to BRAF/MEK inhibitors, establish the specific signature of p53 family isoform expression that could indicate targeted therapy effectiveness and identify potential therapeutic targets.]]></summary_en></project><project>
<id>15271</id><title_hr><![CDATA[Društvena odgovornost i profesionalna etika hrvatskih istraživača]]></title_hr><title_en><![CDATA[Social Responsibility and Professional ethics of Croatian Researchers]]></title_en><user_id>18914</user_id><user_firstLast_name>Marija Brajdić Vuković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-2911</code><acronim><![CDATA[RESETH]]></acronim><duration>16.12.2023 - 15.12.2027</duration><status>U tijeku</status><financ_value>98.488,60 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Sociologija, </scie_field_hr><scie_field_en>Sociology, </scie_field_en><institution_hr><![CDATA[Institut za društvena istraživanja]]></institution_hr><institution_en><![CDATA[Institute for Social Research in Zagreb]]></institution_en><team_members_id>20259, 19460, 17758, 1441, 18911, 29448, 1329, 12897, 6920, 869946, 872918, </team_members_id><team_members_names><![CDATA[Anita  Dremel, Adrijana Šuljok, Ana Maskalan, Pavel Gregorić, Bojana Vignjević Korotaj, Ivan Flis, Paško Bilić, Mislav Žitko, Nikola Petrović, Ivan Tranfić, Magda Profaca, ]]></team_members_names><keywords_hr><![CDATA[društvena odgovornost znanosti, znanost i društvena kriza, odgovorni istraživački proces, kreativne istraživačke metode, RRI IMAGINE]]></keywords_hr><keywords_en><![CDATA[social responsibility of science, science and social crises, responsibile research process, creative research methods, RRI IMAGINE]]></keywords_en><summary_hr><![CDATA[Glavni istraživački fokus ovog projekta jest pitanje što znači biti društveno odgovoran istraživač i kako društvenu odgovornost znanosti opisuju, doživljavaju i prakticiraju hrvatski istraživači iz prirodnih, biomedicinskih, tehničkih i društvenih znanosti. Osnova društvene odgovornosti znanosti u našem poimanju povezana je s profesionalnom etikom znanosti kroz vrijednosti, stavove i ponašanje istraživača. Naš projekt istražuje što je društveno odgovoran istraživač odozdo prema gore, kao smisao i sadržaj koji dolazi iz same znanstvene zajednice i kroz njezinu svakodnevnu istraživačku praksu. U Hrvatskoj nema istraživačkih projekata, analiza ili teorijskih radova koji su bili dubinski fokusirani na temu društvene odgovornosti hrvatskih znanstvenika. I u međunarodnom kontekstu studije na znanstvenicima o društvenoj odgovornosti znanosti rijetke su te se uglavnom odnose na znanosti o životu i biotehnologiju i provedene su na relativno malim uzorcima. Praktično nema studija o društvenoj odgovornosti znanosti u vrijeme društvenih kriza kao što je pandemija Covid-19. Znanstveni ciljevi projekta su dati uvid u značenja koja hrvatski istraživači pridaju društvenoj odgovornosti znanosti, te u svjetlu recentne, i budućih društvenih kriza. Zatim, opisati procese, iskustva, te ponašanja u vezi s društvenom odgovornošću prije i tijekom istraživačkog procesa i u rezultatima, te komunikaciji s javnošću. Ovaj će projekt također opisati i analizirati društvenu odgovornost znanosti u nacionalnom kontekstu. Osim anketa i polu-strukturiranih intervjua, koristit ćemo kreativne metode istraživanja. Širi društveni ciljevi su doprinijeti politikama društvene odgovornosti znanosti u Hrvatskoj, doprinijeti pojačanoj refleksivnosti znanstvenika o odnosu znanosti i društva i ulozi znanosti u društvu, te doprinijeti idejama vezanim uz angažman i ulogu javnosti u sustavu znanosti.]]></summary_hr><summary_en><![CDATA[The main research focus of this project is at what it means to be a socially responsible researcher and how the social responsibility of science is understood, described, experienced and practiced by Croatian researchers in the natural, biomedical, technical, and social sciences. The basis of the social responsibility of science is connected with the professional ethics of science through the values, attitudes and behavior of researchers. Our project explores what a socially responsible researcher is from the bottom up, as meaning and content that comes from the scientific community itself and through its everyday research practice. In Croatia, there are no research projects, analyses or theoretical works that are deeply focused on the topic of social responsibility of scientists. Even in the international context, studies on scientists are rare and mostly refer to life sciences and biotechnology and have been conducted on relatively small samples. There are practically no studies on the social responsibility of science in times of social crises such as the Covid-19 pandemic. The scientific goals of the project are to provide insight into the meanings that Croatian researchers attach to social responsibility, and in the light of recent and future social crises. Further, to describe the processes, experiences, and behaviors related to social responsibility before and during the research process and in public outreach. This project will also analyze the social responsibility of science in the national context. Together with surveys and semi-structured interviews, we will use creative research methods. Broader social goals are to contribute to policies related to the social responsibility of science in Croatia, to contribute to the reflexivity of scientists about the relationship between science and society and the role of science in society, and to contribute to ideas related to the role of the public in the science system.]]></summary_en></project><project>
<id>15276</id><title_hr><![CDATA[Upravljanje standardnim jezikom u Hrvatskoj i Srednjoj Europi od 1945. do danas]]></title_hr><title_en><![CDATA[Standard language management in Croatia and Central Europe from 1945 to the present]]></title_en><user_id>29710</user_id><user_firstLast_name>Petar Vuković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-4172</code><acronim><![CDATA[SLM-HRCE]]></acronim><duration>20.12.2023 - 19.12.2027</duration><status>U tijeku</status><financ_value>101.944,38 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filologija, </scie_field_hr><scie_field_en>Philology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>29714, 866152, 866102, 6970, 866191, 29729, 866207, 866273, 29742, 29715, 872943, </team_members_id><team_members_names><![CDATA[Krešimir Mićanović, Mojca Smolej, Helena Dobrovoljc, Martina Grčević, Magdalena Zawislawska, Dorota Jedynak, Iwona Burkacka, Elod Dudas, Gabriela Múcsková, Kristina Katalinić, Boris Kern, ]]></team_members_names><keywords_hr><![CDATA[Standardni jezik, upravljanje jezikom, pravopisna kodifikacija, gramatička kodifikacija, leksička kodifikacija, jezična ideologija, Srednja Europa]]></keywords_hr><keywords_en><![CDATA[Standard language, language management, orthographical codification, grammatical codification, lexical codification, language ideology, Central Europe]]></keywords_en><summary_hr><![CDATA[Glavni je cilj predloženog istraživačkog projekta izraditi poredbeni sociolingvistički opis, analizu i kritiku jezične kodifikacije u Hrvatskoj, Sloveniji, Mađarskoj, Slovačkoj, Češkoj i Poljskoj od 1945. do danas. Riječ je o zemljama čiji su jezici standardizirani u sličnim društveno-povijesnim kontekstima i u kojima jezična kodifikacija do danas ima velik socijalni ugled. Istraživanjem će biti obuhvaćena tri glavna oblika jezične kodifikacije: pravopisna, gramatička i leksička. Osim na glavne kodifikacijske radove, analiza će biti usmjerena i na periodiku u kojoj su objavljivane reakcije na te radove i polemike o njima te na različite povijesne izvore koji zrcale jezičnu politiku i ideologiju na kojoj počiva jezična kodifikacija. Istraživanje će se metodološki temeljiti na teoriji upravljanja jezikom, poststrukturalističkom pristupu jezičnoj politici i jezičnom planiranju za koji su karakteristične dvije glavne pretpostavke: prva je uvjerenje da se organizirane intervencije u jezik ne bi smjele izvoditi monološki „od gore“, a druga da nijedna intervencija u jezik nije vrijednosno i ideološki neutralna. U skladu s tim bit će opisane promjene jezične kodifikacije u navedenom razdoblju, kako su te promjene bile argumentirane i kritizirane, kako su ih vidjeli i prihvaćali govornici, te na kraju kakav je bio njihov odnos prema stvarnoj jezičnoj uporabi. Veliku važnost imat će i rekonstrukcija političkih i ideoloških utjecaja na jezičnu kodifikaciju. Komparativni pristup omogućit će da se izvedu generalizacije za sve jezike koji su predmet istraživanja. Rezultati istraživanja doprinijet će razumijevanju upravljanja standardnim jezikom u Srednjoj Europi, a imat će i praktičnu primjenu u aktualnoj praksi jezične kodifikacije u Hrvatskoj i u široj regiji.]]></summary_hr><summary_en><![CDATA[The main objective of the research project is to provide a comparative sociolinguistic description, analysis, and critique of language codification in Croatia, Slovenia, Hungary, Slovakia, Czechia and Poland from 1945 to the present. Languages of these countries have been standardized in similar socio-historical contexts, and in all of them language codification enjoys high social esteem. The research will focus on three basic forms of language codification: orthographical, grammatical, and lexical. In addition to the main codification works, the subject of the analysis will also be periodicals in which reactions to these works and debates about them have been published, as well as various historical sources reflecting policies and ideologies on which language codification was based. The research will be methodologically based on the language management theory, a post-structuralist approach to language policy and planning characterized by two main assumptions: the first is the belief that organized interventions into language should not be performed monologically in a &#39;&#39;top-down&#39;&#39; way, and the second that no intervention into language is value-free or ideologically neutral. In accordance with these assumptions, changes in linguistic codifications will be described, as well as how these changes were argued for and against, how they were perceived and received by language users, and how they reflect actual language use. The reconstruction of political and ideological influences on language codification will also be carried out. A comparative approach will allow for generalizations to be made for all the languages under study. The results of the research will contribute to the understanding of standard language management in Central Europe, and will have practical application in the current language codification practices in Croatia and in the wider region.]]></summary_en></project><project>
<id>15279</id><title_hr><![CDATA[Mehanizmi dugotrajnog preživljavanja Francisella unutar ameba]]></title_hr><title_en><![CDATA[Mechanisms of long-term survival of Francisella in amoebae]]></title_en><user_id>114</user_id><user_firstLast_name>Marina Šantić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-8445</code><acronim><![CDATA[FranAm]]></acronim><duration>15.12.2023 - 14.12.2027</duration><status>U tijeku</status><financ_value>199.031,17 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, Kliničke medicinske znanosti, Javno zdravstvo i zdravstvena zaštita, </scie_field_hr><scie_field_en>Basic Medical Sciences, Clinical sciences, Public health and health services, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Medicine]]></institution_en><team_members_id>6961, 12452, 25206, 27882, 865956, 866042, 865982, 19177, 23489, 869768, 873093, </team_members_id><team_members_names><![CDATA[Maja Abram, Mirna Mihelčić, Ina Viduka, Maša Knežević, Anders Sjostedt, Jana Klimentova, Jiri Stulik, Andreja Zubković, Dijana Detel, Linda Jerinić, Vedrana Nefat, ]]></team_members_names><keywords_hr><![CDATA[Francisella, ameba, cista, unutarstanični profil, in vivo]]></keywords_hr><keywords_en><![CDATA[Francisella, amoeba, cyst, intracellular profile, in vivo]]></keywords_en><summary_hr><![CDATA[Francisella tularensis je gram-negativna bakterija, uzročnik zoonotske bolesti tularemije. Tularemija je prijavljena prvenstveno u područjima u blizini raznolikih voda. Naša i druga in vitro istraživanja pokazala su da se F. tularensis subsp. tularensis, F. holarctica i F. novicida razmnožavaju u Acanthamoeba castellanii i Hartmannella vermiformis, čineći amebe važnim okolišnim rezervoarom ovih bakterija. Međutim, nije poznato koliko dugo Francisella može preživjeti u amebnim cistama kao ni mehanizmi preživljavanja i oporavka u stanicama sisavaca. Pretpostavljamo da proces transformacije ameba iz stadija trofozoita u ciste u potpunosti regulira Francisella. Očekujemo da ćemo odrediti optimalne uvjete za oporavak bakterija iz cista u različitim hranidbenim uvjetima, stanicama sisavaca i u modelu miša. Nadalje, cilj nam je na modelu miša utvrditi hoće li Francisella uzgojena u amebnoj cisti izazvati pojačani ili smanjeni imunološki odgovor. Na temelju naših preliminarnih rezultata, očekujemo pokazati da Francisella odgađa apoptozu ameba i pokreće proces autofagije u svrhu dugotrajnog preživljavanja u cistama. Proteomske analize koristit ćemo za proučavanje fenotipa Francisella koji se mijenja tijekom transformacije ameba iz trofozoita u cistu. Za razumijevanje promjena u ekspresiji gena tijekom životnog ciklusa Francisella u amebama koristit će se nova metoda transkriptomike. Tri vrste francisela, Francisella tularensis subsp. holarctica soj LVS, F. philomiragia i F. novicida te A. castellanii koristit će se u ovom istraživanju. U predloženom projektu kombinirat ćemo napredne tehnologije kako bismo opisali i identificirali nove čimbenike virulencije Francisella na temelju njihovog unutarstaničnog životnog ciklusa u amebama (trofozoit/cista) koji omogućavaju bakterijama uspješnu infekciju stanica sisavaca. Projekt će doprinijeti povećanju broja visokokvalificiranih mladih istraživača iskusnih u radu s ovim infektivnim i važnim javnozdravstvenim patogenima. ]]></summary_hr><summary_en><![CDATA[Francisella tularensis is a gram-negative bacterium, the causative agent of the zoonotic disease tularemia. Tularemia has been reported primarily in areas near water sources. Our and other in vitro studies have shown that F. tularensis subsp. tularensis, F. holarctica, and F. novicida can replicate in Acanthamoeba castellanii and Hartmannella vermiformis, making amoebae an important environmental reservoir for bacteria. However, it is not known for how long Francisella can survive in amoebae cysts and the mechanisms of survival and recovery in mammalian cells. We hypothesize that the process of transformation of amoebae from the trophozoite stage to cysts is regulated entirely by Francisella. We expect to find the optimal conditions for recovery of bacteria from cysts in different conditions. Our goal is to determine, in mice model, whether Francisella cultured in an amoeba cyst would elicit an enhanced or reduced immunological response. Based on our preliminary results, we expect to demonstrate that Francisella species postpone apoptosis and initiate the autophagy cycle for long-term survival in cysts. In addition, we will apply the proteomic approach to study the phenotype of Francisella that changes as the amoebae transforms from trophozoite to cyst. To understand the changes in gene expression throughout the life cycle of Francisella in amoebae, the novel method of transcriptomics will be used. Three Francisella species, Francisella tularensis subsp. holarctica strain LVS, F. philomiragia and F. novicida and A. castellanii will be included in this study. In the proposed project, we will combine advanced techniques to identify novel virulence factors of Francisella based on their intracellular life in amoebae/cysts for successful infection cycle in mammalians. The project will help increase the number of highly qualified young researchers with experience working with emergent infectious and important public health pathogens. ]]></summary_en></project><project>
<id>15282</id><title_hr><![CDATA[Klima i ekstremni vremenski uvjeti u prirodnom i urbanom okolišu Hrvatske ]]></title_hr><title_en><![CDATA[Croatian climate and extreme conditions in urban and natural environment   ]]></title_en><user_id>2650</user_id><user_firstLast_name>Ivana Herceg Bulić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-4144</code><acronim><![CDATA[CroClimExtremes ]]></acronim><duration>31.12.2023 - 30.12.2027</duration><status>U tijeku</status><financ_value>199.084,21 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Geofizika, </scie_field_hr><scie_field_en>Geophysics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>862800, 1315, 3099, 1417, 19109, 19684, 2552, 865496, 865598, 865562, 22511, 829, 865843, 865993, 866599, 869939, 25094, 869948, 873049, 873099, 873100, 873098, </team_members_id><team_members_names><![CDATA[Marijana Boras, Iva Međugorac, Dalibor Paar, Zoran Pasarić, Hrvoje Planinić, Željko Večenaj, Ksenija Cindrić Kalin, Vladimir Đurđević, Martin King, Fred Kucharski, Irena Nimac, Jadranka Šepić, Ksenija Protrka, Matija Kranjcevic, Hrvoje Škrabić Škrabić, Marina Dajaković, Sara Ivasić, Ivan Lončar-Petrinjak, Karla Mlađen, Karlo Srdoč, Anđela Šantić, Domagoj Berečić, ]]></team_members_names><keywords_hr><![CDATA[Klima, ekstremi, urbana područja, planinska područja, morska razina ]]></keywords_hr><keywords_en><![CDATA[Climate, extremes, urban areas, mountainous areas, sea level]]></keywords_en><summary_hr><![CDATA[Projekt se bavi klimatskim promjenama i vremenskim ekstremima u iznimno ranjivim dijelovima okoliša (gradovi, planinska područja i more). Sastoji se od četiri modula unutar kojih će se istraživati teme koje su važne za širu znanstvenu zajednicu, ali su ujedno od posebnog značaja za Hrvatsku: 1. atmosferski procesi velike prostorne skale koji podržavaju razvoj ekstremnih uvjeta na području Europe, 2. utjecaj ekstremnih vremenskih događaja na klimatska obilježja gradova u Hrvatskoj – toplinski valovi, intenzivna kratkotrajna oborina, združeni i uzastopni ekstremi, 3. utjecaj atmosferskih procesa na pojavu iznimnih vodostaja u Jadranu, 4. pojava opasnih vremenskih prilika u prirodnom okolišu kompleksne topografije (planina Biokovo). Osmišljen je interdisciplinarni pristup koji će provoditi multidisciplinarna grupa iskusnih domaćih i inozemnih znanstvenika sa znanjima i kompetencijama iz različitih područja (klimatologija, meteorologija, oceanografija, fizika, geografija, matematika), mladih znanstvenika na početku karijere (doktorandi) te također mladih, ali iskusnijih znanstvenika (poslijedoktorandi). Unaprijedit će se i primijeniti metodologije za istraživanje navedenih tema, analizirat će se empirijski i modelirani podaci te će se provoditi klimatsko modeliranje atmosferskim modelom opće cirkulacije ICTP AGCM i urbanim klimatskim modelom MUKLIMO. Osigurat će se kontinuirana mjerenja morske razine u Bakru. Na planini Biokovo će se uspostaviti mreža mjernih instrumenata, što predstavlja prvu mrežu planinskih mjerenja takvog opsega u Hrvatskoj. Na odabranoj će se lokaciji uz šetnicu SkyWalk postaviti meteorološka postaja s prijenosom podataka u realnom vremenu. Važan cilj projekta je izobrazba mladih znanstvenika koji će prijenosom znanja i vještina od iskusnijih suradnika ojačati svoje znanstvene kompetencije. Posebno će se voditi računa o diseminaciji rezultata, vidljivosti projekta, edukaciji i suradnji s potencijalnim korisnicima rezultata istraživanja. ]]></summary_hr><summary_en><![CDATA[The project deals with climate change and weather extremes in highly vulnerable parts of the environment (cities, mountainous areas and the sea). Topics important for the wider scientific community, but particularly Croatia, will be researched through four modules: 1. large-scale atmospheric processes supporting development of extremes in Europe, 2. the impact of extreme weather events on the climatic characteristics of Croatian cities – heat waves, intense precipitation, compound and successive extremes, 3. the atmospheric influence on the occurrence of extreme sea-levels in the Adriatic, 4. dangerous weather conditions in the natural environment of complex topography (Mount Biokovo). An interdisciplinary approach has been devised, which will be carried out by a multidisciplinary group of experienced domestic and foreign scientists with competencies in various fields (climatology, meteorology, oceanography, physics, geography, mathematics), young scientists (PhD students) and young experienced scientists (postdoctoral students). Methodologies for the research of the mentioned topics will be improved and applied, empirical and modelled data will be analysed and climate modelling will be carried out using the global model ICTP AGCM and the urban climate model MUKLIMO. Continuous measurements of the sea level in Bakar, Croatia, will be ensured. A network of measuring instruments will be established on Mount Biokovo, which represents the first network of mountain measurements of such scope in Croatia. Additionally, a weather station with real-time data transmission will be set up near the Biokovo viewpoint SkyWalk. An important goal of the project is the education of young scientists who will strengthen their scientific competencies by transferring knowledge and skills from experienced colleagues. Special attention will be paid to the dissemination of results, visibility of the project, education, and cooperation with potential users of research results.]]></summary_en></project><project>
<id>15283</id><title_hr><![CDATA[Između rata i mira. Transformacija kulturnog krajolika međuriječja Krke i Cetine od protohistorije do kasne antike]]></title_hr><title_en><![CDATA[Between war and peace. The transformation of the cultural landscape between the Krka and Cetina rivers from Protohistory to Late Antiquity]]></title_en><user_id>7512</user_id><user_firstLast_name>Domagoj Tončinić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-6994</code><acronim><![CDATA[TiHiTransForm]]></acronim><duration>20.12.2023 - 19.12.2027</duration><status>U tijeku</status><financ_value>119.450,54 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Arheologija, </scie_field_hr><scie_field_en>Archeology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>7532, 7513, 7516, 23601, 19244, 17731, 7519, 23814, 7536, 4028, 25773, 11234, </team_members_id><team_members_names><![CDATA[Sanja Ivčević, Iva Kaić, Vinka Matijević, Joško Zaninović, Miroslav Vuković, Mirna Cvetko, Ina Miloglav, Emil Podrug, Zrinka Buljević, Mirjana Sanader, Domagoj Bužanić, Jelena Lapić, ]]></team_members_names><keywords_hr><![CDATA[rimska Dalmacija, transformacija kulturnog krajolika, daljinska istraživanja, rimska vojska, formiranje naselja, ekonomija, antika, rano kršćanstvo]]></keywords_hr><keywords_en><![CDATA[Roman Dalmatia, cultural landscape transformation, remote sensing, Roman military, settlement formation, economy, Antiquity, early Christianity]]></keywords_en><summary_hr><![CDATA[Glavni cilj projekta TiHiTransForm je utvrditi kako su i u kojoj mjeri potrebe za obranom i nadzorom prostora kroz nekoliko ključnih povijesnih procesa od protohistorije do kasne antike utjecale na transformaciju kulturnog krajolika međuriječja Krke i Cetine. Namjera projekta je istražiti odabrana potencijalna arheološka nalazišta koja nisu bila predmetom istraživanja prethodnog projekta AdriaRom (HRZZ-IP-2018-01-4934, voditelj: izv. prof. dr. sc. D. Tončinić). Ciljani prostor istraživanja projekta TiHiTransForm stoga će obuhvatiti ono područje koje je u okviru projekta AdriaRom snimljeno LiDAR-om, a to je prostor između Krke i Cetine. Hipoteza projekta TiHiTransForm je da su potrebe obrane i nadzora utjecale na transformaciju kulturnog krajolika međuriječja Krke i Cetine u razdoblju od protohistorije do kasne antike. S obzirom na cilj i hipotezu, formirana su sljedeća istraživačka pitanja:  IP1.) Koja je funkcija gradinskih položaja nakon uspostave rimske vlasti i tijekom kasne antike?; IP2.) Kako je podizanje rimskih vojnih logora na delmatskom limesu utjecalo na formiranje civilnih naselja (canabae, vici)?; IP3.) Kako gospodarske aktivnosti rimske vojske utječu na transformaciju kulturnog krajolika?; IP4.) Kako je odlazak rimske vojske utjecao na daljnji razvoj urbanih i ruralnih naselja civilnog karaktera, a s time i na nadzor nad prometom ljudi i roba?; IP5.) Kakav je odnos kasnoantičkih naselja i vila rustika s ranokršćanskim sakralnim građevinama?; IP6.) Koja je funkcija položaja nekadašnjih rimskih vojnih logora na delmatskom limesu tijekom kasne antike? Trenutačno stanje u temi istraživanja projekta TiHiTransForm, u kombinaciji s rezultatima dobivenim u okviru projekta AdriaRom, pokazuju da se implementacijom inovativne metodologije može odgovoriti na glavni cilj i hipotezu projekta TiHiTransForm. ]]></summary_hr><summary_en><![CDATA[The main goal of the TiHiTransForm project is to determine how and to what extent the need for defense and control through several key historical processes influenced transformation of the cultural landscape between the Krka and Cetina rivers from Protohistory to Late Antiquity. The project aims to investigate specific archaeological sites that were not the subject of research in the previous project AdriaRom (HRZZ-IP-2018-01-4934, PI: D. Tončinić, Ph.D.). The target research area of the TiHiTransForm project will cover the area that was scanned with LiDAR within AdriaRom project, i.e. the area between Krka and Cetina rivers. TiHiTransForm project hypothesizes that the need for defense and control influenced the transformation of the cultural landscape between the Krka and Cetina rivers in the period from Protohistory to Late Antiquity. Concerning the goal and hypothesis, the following research questions were formed: RQ1) What is the function of hillfort sites after the establishment of Roman rule and during Late Antiquity?; RQ2) How did the establishment of Roman military camps on the Delmataean limes affect the formation of civilian settlements?; RQ3) How did the economic activities of the Roman army affect the transformation of the cultural landscape?; RQ4) How did the departure of the Roman legions affect the further development of urban and rural settlements of civilian character, and with it the control over traffic of people and goods?; RQ5) What was the relationship between the Late Antique settlements and villae rusticae with the early Christian sacral buildings?; RQ6) What was the function of the former Roman military sites on the Delmataean Limes during the Late Antiquity? The current state of research on the topic of the TiHiTransForm project, combined with the results obtained within the AdriaRom project, show that the implementation of this innovative methodology can answer the main goal and hypothesis of the TiHiTransForm project.]]></summary_en></project><project>
<id>15289</id><title_hr><![CDATA[Prostori modularnih i automorfnih formi i teorija reprezentacija u okviru Langlandsovog programa]]></title_hr><title_en><![CDATA[Spaces of Modular and Automorphic Forms and Representation Theory within the Framework of the Langlands program]]></title_en><user_id>890</user_id><user_firstLast_name>Neven Grbac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-4615</code><acronim><![CDATA[SMART-Langlands]]></acronim><duration>15.12.2023 - 14.12.2027</duration><status>U tijeku</status><financ_value>140.818,90 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište Jurja Dobrile u Puli]]></institution_hr><institution_en><![CDATA[Juraj Dobrila University of Pula]]></institution_en><team_members_id>23430, 23409, 863, 1000, 1079, 831, 850, 820, 1154, 17779, 866052, 866075, 866211, 866056, 866251, 866327, 869744, 1409, </team_members_id><team_members_names><![CDATA[Petar Bakić, Barbara Bošnjak, Darija Brajković Zorić, Igor Ciganović, Marcela Hanzer, Iva Kodrnja, Ivan Matić, Goran Muić, Marko Tadić, Sonja Žunar, Alberto Minguez, GORDAN SAVIN, Dubravka Ban, Harald Grobner, Joachim Schwermer, Erez Lapid, Lovro Greganić, Tihana Galinac Grbac, ]]></team_members_names><keywords_hr><![CDATA[Langlandsov program, automorfne forme, modularne forme, teorija reprezentacija, kohomologija aritmetičkih grupa ]]></keywords_hr><keywords_en><![CDATA[Langlands program, automorphic forms, modular forms, representation theory, cohomology of arithmetic groups]]></keywords_en><summary_hr><![CDATA[Langlandsov program, jedno je od centralnih područja teorije brojeva, ali i čitave suvremene matematike. To je složen sustav slutnji i korespondencija koji predviđa duboku funktorijalnu (algebarsku) povezanost teorije brojeva (Galoisove reprezentacije), matematičke analize (automorfne i modularne forme) i geometrije (eliptičke krivulje, Shimurine mnogostrukosti, kohomologija). Istraživanja planirana u ovom projektnom prijedlogu usmjerena su većim dijelom na analitičke aspekte Langlandsovog programa. Glavni problemi su razumijevanje strukture prostora klasičnih modularnih formi i automorfnih formi na reduktivnim algebarskim grupama definiranim nad poljima algebarskih brojeva te eksplicitne konstrukcije netrivijalnih modularnih i automorfnih formi. Teorija reprezentacija reduktivnih grupa nad globalnim i lokalnim poljima ne planira se koristiti jedino za algebarski opis tih struktura, nego i proučavati kao poseban dio teorije, posebno u smislu nekomutativne harmonijske analize i unitarizabilnosti. U tom dijelu projekta, glavni problemi su razumijevanje strukture parabolički induciranih reprezentacija, klasifikacija unitarnih reprezentacija i drugih klasa reprezentacija, s posebnim naglaskom na reprezentacije klasičnih p-adskih grupa. Razumijevanje strukture prostora automorfnih formi, kao i njihove eksplicitne konstrukcije, imaju i važne geometrijske primjene poput opisa automorfne kohomologije i kohomologije aritmetičkih grupa te eksplicitne konstrukcije klasa kohomologije. U sklopu projekta planira se istraživanja i u tom smjeru.]]></summary_hr><summary_en><![CDATA[The Langlands program is one of the central parts of number theory, but also the mathematics as a whole. It is a complicated, yet natural, system of conjectures and expected correspondences which predicts deep functorial (algebraic) relationship between number theory (Galois representations), mathematical analysis (automorphic and modular forms) and geometry (elliptic curves, Shimura varieties, cohomology). The research planned in this project proposal is mostly directed towards analytic aspects of the Langlands program.  The main problems are concerned with the understanding of the structure of spaces of modular and automorphic forms on reductive algebraic groups defined over an algebraic number field, as well as the explicit constructions of non-trivial modular and automorphic forms. The representation theory over global and local fields is not planned only as a convenient tool for the algebraic description of those structures, but also as a separate field of research, especially in view of the non-commutative harmonic analysis and unitarizability. In the field of planned research, the main problems are the thorough understanding  of the structure of parabolically induced representations, classification of unitary and other classes of representations, with special emphasis on the representations of classical p-adic groups.  The understanding of the structure of spaces of automorphic forms, and their explicit constructions, have important geometric applications such as the description of the automorphic cohomology, the cohomology of arithmetic groups, and explicit constructions of cohomology classes. The research in that direction is also planned in this proposal. ]]></summary_en></project><project>
<id>15290</id><title_hr><![CDATA[Funkcionalni kompleksni materijali: elektronski podsustavi i valne funkcije]]></title_hr><title_en><![CDATA[Functional Complex Materials: Electronic Subsystems and Wave Functions]]></title_en><user_id>4289</user_id><user_firstLast_name>Neven Barisic</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-3382</code><acronim><![CDATA[FunSubWave]]></acronim><duration>31.12.2023 - 30.12.2027</duration><status>U tijeku</status><financ_value>197.093,37 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>3420, 97, 866046, 26812, 5194, 866053, 865337, 4897, 866044, 25109, 866055, 2708, 4336, 866048, 25108, 866131, 868454, </team_members_id><team_members_names><![CDATA[Ivo Batistić, Ante Bilušić, Maria Čebela, Naveen Kumar Chogondahalli Muniraju, Trpimir Ivšić, Nikolina Penić, Gaurav Pransu, Denis Sunko, Wojciech Tabis Tabis, Yuki Utsumi Boucher, Jerzy Cioslowski, Mario Basletić, Osor  Slaven Barišić, Priyanka Reddy, Juraj Krsnik, Josipa Šćurla, Kamila Komedera, ]]></team_members_names><keywords_hr><![CDATA[Elektronska svojstva materijala, transport, optička vodljivost, supravodljivost, elektronske orbitale, kondenzirana tvar]]></keywords_hr><keywords_en><![CDATA[Electronic properties of materials, transport, optical conductivity, superconductivity, electron orbitals, condensed matter]]></keywords_en><summary_hr><![CDATA[Projekt istražuje detaljne mikroskopske mehanizme funkcionalizacijeelektronskih orbitala primarno u tri zanimljive klase modernih materijala: kupratima i pniktidima, koji su visokotemperaturni supravodiči, te u novom spoju, po prvi puta sintetiziranom u obliku velikih monokristala, sulfasoli murunskitu i iz njega izvedenim spojevima, koji kemijski i elektronski interpoliraju između prve dvije. Glavna je ideja da se funkcionalni elektroni dijele na podsustave koji međudjeluju, a što je već prethodno utvrđeno na kupratima. Istraživanja su podijeljena u više međusobno ovisnih skupina. Prvu čine sinteze i karakterizacije, koje će značajno unaprijediti hrvatske kapacitete u tom kritičnom području razvoja modernih materijala. Središnje mjesto čine suvremene spektroskopske tehnike, čija je svrha najbolje moguće razlučivanje mikroskopskih stanja elektrona, odgovornih za njihovu funkciju. Taj će se dio razvijati u uskoj sprezi sa računima funkcionala gustoće (DFT), čija je svrha i interpretacija mjerenja i upravljanje njima. Treću skupinu čine istraživanja čija je glavna svrha razvoj ekspertize. S eksperimentalne strane, to je razvoj tehnika poput naprednih spektroskopskih mjerenja (optičke vodljivosti do rendgenske spektroskopije) u funkciji (hidrostatskog ili pak uniaksialnog tlaka) ili pak pulsne laserske depozicije tankih filmova materijala zanimljivih za projekt. S teorijske je primjena avangardnih metoda algebarske geometrije za kvalitativnu karakterizaciju jako koreliranih stanja malog broja elektrona]]></summary_hr><summary_en><![CDATA[The project investigates detailed microscopic mechanisms of the functionalization of electronic orbitals in three interesting classes of modern materials: cuprates and pnictides, both high-Tc superconductors, and a new compound, the sulfosalt murunskite, synthesized for the first time in the form of large monocrystals, and with compounds derived from it, which interpolate between the former two chemically and electronically. The main idea is that the functional electrons can be divided into mutually interacting subsystems, which has already been verified in case of the cuprates. The investigations are divided into several mutually dependent groups. The first are synthesis and characterization, which are planned to significantly advance Croatian capabilities in this critical realm for the development of modern materials. The central place is taken by advanced spectroscopic techniques, whose purpose is the best possible distinction of microscopic states of the electrons, responsible for their functionality. This part will be developed in tight feedback with density-functional calculations, whose purpose is both interpretation and guidance of measurements. The third group are investigations with the main purpose of developing expertise. On the experimental side, they are the development of techniques such as advanced spectroscopic measuremets (from optical conductivity to X-ray spectroscopy) as a function of hydrostatic or uniaxial pressure, or pulse-laser deposition techniques of thin films of materials of interest to the project. On the theoretical side is the application of advanced techniques of algebraic geometry for the qualitative characterization of strongly correlated few-electron states. ]]></summary_en></project><project>
<id>15292</id><title_hr><![CDATA[Istraživanje subkliničkih markera multiple skleroze]]></title_hr><title_en><![CDATA[Investigation of subclinical markers of multiple sclerosis]]></title_en><user_id>83</user_id><user_firstLast_name>Maja Rogić Vidaković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-6203</code><acronim><![CDATA[SUBCLIN-MS]]></acronim><duration>31.12.2023 - 30.12.2027</duration><status>U tijeku</status><financ_value>120.898,95 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Kliničke medicinske znanosti, Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Clinical sciences, Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Split School of Medicine]]></institution_en><team_members_id>809, 53, 1202, 13173, 865557, 865556, 29155, 865577, 865549, 869727, </team_members_id><team_members_names><![CDATA[Nikolina Režić Mužinić, Anita Markotić, Angela Mastelić, Krešimir Dolić, Antonia Bralic, Marija Bušić, Joško Šoda, Eni Jadrijević Kodžoman, SANDA PAVELIN, Jasna Duranović, ]]></team_members_names><keywords_hr><![CDATA[multipla skleroza, evocirani potencijali, sublikički markeri, MRI, TMS, MRI, protočna citometrija, obrada signala]]></keywords_hr><keywords_en><![CDATA[multiple sclerosis, evoked potentials, subclinical markers, MRI, TMS, MRI, flow cytometry, signal analysis]]></keywords_en><summary_hr><![CDATA[Multipla skleroza (MS) je upalna autoimuna bolest središnjeg živčanog sustava (SŽS) nepoznatog uzroka koju karakteriziraju demijelinizirajuće lezije bijele tvari i degeneracija neurona uzrokujući različite simptome (motoričke i senzorne disfunkcije, kognitivna oštećenja, poremećaje raspoloženja, umor). Relapsno-remitentni oblik bolesti (RRMS) je najčešći oblik bolesti s prevalencijom od oko 80 do 90% osoba s MS-om. Primarni progresivni oblik bolesti (PPMS) značajno je rjeđi i javlja se u 10% bolesnika, dok daljnja progresija bolesti ukazuje na prijelaz u sekundarno-progresivni oblik bolesti (SPMS). Patofiziološki korelati i odnos s kliničkim nalazima i simptomima nisu u potpunosti razjašnjeni. Stoga su potrebne preciznije analize s ciljem otkrivanja novih subkliničkih markera koji bi mogli identificirati patološke događaje MS-a te omogućiti praćenje tijeka bolesti kao što su suptilne promjene prije klinički vidljive progresije bolesti. U predloženom istraživanju provest će se longitudinalno praćenje funkcionalnog integriteta SŽS-a ispitanika s RRMS-om i PPMS-om s ciljem pronalaska subkliničkih markera MS-a. Funkcionalni integritet SŽS-a procijenit će se neurofiziološkim testovima (motoričkim, somatosenzoričkim i vidnim evociranim potencijalima), neuroradiološkom evaluacijom lezija, analizom krvnih markera (monocitnih i limfocitnih subpopulacija) i neuropsihološkom procjenom. Preliminarni rezultati naše grupe upućuju na korelaciju neurofizioloških nalaza (motoričkih evociranih potencijala) sa standardnom neuroradiološkom i neurološkom procjenom. Analiza krvnih markera upućuje na postojanje razlika u monocitnim subpopulacijama ispitanika s MS-om koji pokazuju odstupanja u mjerama latencije motoričkih evociranih potencijala.]]></summary_hr><summary_en><![CDATA[Multiple sclerosis (MS) is an inflammatory autoimmune disease of the central nervous system (CNS), of unknown cause, characterized by demyelinating lesions of the white matter and degeneration of neurons, which causes the appearance of various symptoms (motor and sensory dysfunctions, cognitive impairment, mood disorders, fatigue). Relapsing-remitting form of the disease (RRMS) is the most common with a prevalence of about 80 to 90% of people with MS. The primary progressive form of the disease (PPMS) is significantly less common and occurs in 10% of patients, while the progression of the disease indicates the transition to the secondary-progressive form of the disease (SPMS). The pathophysiological correlates and the relationship with clinical findings and symptoms are not fully elucidated, which suggests a more precise analysis and the detection of new subclinical markers that could identify the pathological events of MS with the aim of monitoring the course of the disease, such as subtle changes before clinically visible disease progression. In the proposed study, longitudinal monitoring of the functional integrity of the CNS of subjects with RRMS and PPMS will be conducted with the aim of investigating subclinical markers of MS disease. The functional integrity of the CNS will be assessed by neurophysiological tests (motor, somatosensory, and visual evoked potentials), neuroradiological evaluation of lesions, analysis of blood markers (monocyte and lymphocyte subpopulations), and neuropsychological assessment. The preliminary results of our group point to the accordance of neurophysiological findings (motor evoked potentials) with standard neuroradiological and neurological assessment. Preliminary analysis of blood markers indicates the existence of differences in monocyte subpopulations of subjects with MS, which are shown by deviations in measures of the latency of motor evoked potentials. ]]></summary_en></project><project>
<id>15293</id><title_hr><![CDATA[Melioracije kontaminiranog tla metalima pomoću biopepela]]></title_hr><title_en><![CDATA[Amelioration of metal-contaminated soil by bioash ]]></title_en><user_id>20684</user_id><user_firstLast_name>Gabrijel Ondrašek</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-7906</code><acronim><![CDATA[BioAsh4Metals ]]></acronim><duration>30.12.2023 - 29.12.2027</duration><status>U tijeku</status><financ_value>181.432,01 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, Interdisciplinarne biotehničke znanosti, </scie_field_hr><scie_field_en>Agriculture, Interdisciplinary biotechnical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Agronomski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Agriculture]]></institution_en><team_members_id>865047, 26235, 26923, 19313, 22785, 23755, 859458, 26311, 869316, 858447, </team_members_id><team_members_names><![CDATA[JELENA HORVATINEC, Radovan Savić, Ivan  Mustać, Monika Zovko, Marina Bubalo Kovačić, Davor Romić, Vjekoslav Tanaskovikj, Nada Maurović, Benjamin Atlija, Marko Reljić, ]]></team_members_names><keywords_hr><![CDATA[Biopepeo, Kontaminacija metalima, Remedijacija, Kemijske melioracije, Biokemijsko modeliranje]]></keywords_hr><keywords_en><![CDATA[Bioash, Metal contamination, Remediation, Chemical amelioration, Biochemical modelling]]></keywords_en><summary_hr><![CDATA[Kao posljedica provedbe Direktive 2009/28 / EZ o promicanju korištenja energije iz obnovljivih izvora, u Hrvatskoj raste broj energetskih postrojenja na biomasu, a njihov nusproizvod (otpad) pepeo biomase (biopepeo), potrebno je pohraniti (iskoristiti) na odgovarajući način. Na temelju naših nedavnih studija, pretpostavlja se da bi zbog svojih specifičnih fizikalno-kemijskih svojstava (pH> 12,5; ogromno aktivno/adsorpcijsko sučelje; značajan sadržaj P, K, Ca, Mg) biopepeo mogao imati niz pozitivnih učinaka i u melioracijama metalima kontaminiranih tala. Naime, Kontaminacija obradivih površina metalima je sve učestaliji oblik antropogene degradacije pedosfere, koji uzrokuje negativne ekonomsko-ekološke posljedice u proizvodnji hrane. Stoga su glavni ciljevi projekta: 1) karakterizirati fizikalno-kemijska svojstva biopepela iz nekoliko različitih postrojenja na biomasu, te utvrditi učinke različitih doza biopepela na 2) kemijske i 3) mikrobiološke promjene u metalima kontaminiranim tlima, 4) vegetacijske parametre i mineralni sastav poljoprivrednih test kultura uzgojenih u takvim tlima. Agronomski fakultet posjeduje svu potrebnu infrastrukturu i većinu laboratorijskih resursa (akreditirani moderni uređaji ICP-OES, HPLC, SFA i veliko iskustvo sa svim relevantnim postupcima/metodama) za uspješno postizanje svih planiranih ciljeva, a napredne mikroskopske i mineraloške analize (SEM-EDS, SIMS, XPS, XRD) će se obaviti u vanjskim laboratorijima. Projekt će doprinijet  razvoju kompetencija postdoc. istraživača, educirati će doktoranda/diplomante i poboljšati međunarodnu prepoznatljivost istraživačkog tima putem web stranice, radionica/okruglog stola i znanstvenog skupa te širenjem rezultata projekta na konferencijama i objavljivanjem najmanje 5 radova u Q1/Q2 časopisima.  Očekuje se da će projekt ponuditi nova rješenja za bolje gospodarenje biopepelom, te metalima kontaminiranih tala kao značajnog i rastućeg problem na nacionalnoj, europskoj i globalnoj razini.]]></summary_hr><summary_en><![CDATA[As a consequence of the implementation of Directive 2009/28/EC on the promotion of the use of energy from renewable sources, the number of biomass plant facilities continues to grow in Croatia, and their by-product (waste) biomass ash (bioash) needs to be stored adequately. Based on our recent studies it is assumed that due to its specific physicochemical properties (pH >12.5; huge active/adsorption interface; significant content of P, K, Ca, Mg) bioash could have a range of positive impacts in amelioration of metal-contaminated soils. Metal contamination of arable land is a rising anthropogenic degradation that causes negative economic and ecological consequences in food production. The main objectives of the project are: 1) to characterize physicochemical properties of bioashes from several biomass plants, and to determine the effects of different bioash levels on 2) chemical and 3) microbial changes in metal-contaminated soils, 4) vegetative parameters and mineral content of agricultural test crops grown in such contaminated soils. The Faculty has all the infrastructure and most laboratory resources needed, accredited with modern instruments (ICP-OES, HPLC, SFA) for the successful accomplishment of all planned activities, with some advanced microscopy and mineralogy analyses (SEM-EDS, SIMS, XPS, XRD) which will be done in external labs. This project will contribute to postdoc. researcher competencies, educate PhD/Masters graduates, and will enhance international recognition of the research work by delivering project website, workshops/round tables and scientific meetings, and by disseminating the project results at conferences and publishing at least 5 papers in Q1/Q2 journals. Finally, the project is expected to provide novel and more sustainable solutions for managing bioash materials and metal-contaminated soils, which represent an increasing environmental issue at national, European and global levels.]]></summary_en></project><project>
<id>15296</id><title_hr><![CDATA[SUPRAMOLEKULSKI I HIBRIDNI METALO-ORGANSKI KOORDINACIJSKI SUSTAVI – KOOPERATIVNI UČINCI I PREDVIĐANJE AKTIVNOSTI/SVOJSTAVA]]></title_hr><title_en><![CDATA[SUPRAMOLECULAR AND HYBRID METAL-ORGANIC COORDINATION ASSEMBLIES – COOPERATIVE EFFECTS AND ACTIVITY/PROPERTY PREDICTION]]></title_en><user_id>134</user_id><user_firstLast_name>Višnja Vrdoljak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-7368</code><acronim><![CDATA[MOCASS]]></acronim><duration>30.12.2023 - 29.12.2027</duration><status>U tijeku</status><financ_value>151.177,92 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>47, 19078, 5462, 27400, 6825, 19084, 57, 634, 27133, 869852, 868019, </team_members_id><team_members_names><![CDATA[Marina Cindrić, Vladimir Damjanović, Tomica Hrenar, Dino Kuzman, Jasna Lovrić, Danijela Musija, Jana Pisk, Mirta Rubčić, Edi Topić, Juraj Toplak, Josipa Sarjanović, ]]></team_members_names><keywords_hr><![CDATA[Metalo-organski, koordinacija, supramolekuslki sustavi, klusteri, POM, hibridi, odnosi struktura-svojstva, funkcionalni materijali, modeliranje]]></keywords_hr><keywords_en><![CDATA[Metal-organic, coordination, supramolecular assemblies, clusters, POM, hybrids, structure-properites relations, functional materials, modeling]]></keywords_en><summary_hr><![CDATA[Interes za supramolekulske i hibridne metalo-organske sustave u kojima koordinacija ima ključnu ulogu nije posljedica samo njihovih interesantnih molekulskih struktura već i raznolikosti njihovih svojstava. Stoga ćemo se u ovom projektu baviti dizajnom: (i) metalocikličkih i polimernih sustava vanadija(V) s hidrazonskim i alkokso ligandima, (ii) hibrida temeljenih na Co-makrokationima i polioksovandatima ili V/Mo-heteropolioksometalatima, i (iii) hibrida V/Mo-heteropolioksometalata kovalentno funkcionaliziranih alkokso-hidrazonskim kompleksnim sustavima. Svaki segment istraživanja obuhvaćat će sintetski, fizikalno-kemijski i računalni aspekt. Cilj ovog projekta ne odnosi se samo na dizajn novih sustava već i na razumijevanje kooperativnih učinaka i mehanizma koji omogućuju njihovo nastajanje te konačno istraživanje njihovih specifičnih svojstava. Detaljna karakterizacija priređenih spojeva bit će ključna za razumijevanje eksperimentalnih i računalnih rezultata istraživanja.Ovi sustavi poslužit će kao idealni modeli za istraživanje katalitičkih procesa i razumijevanje odnosa strukture i aktivnosti te svojstava spojeva. Istražiivat će se njihova uloga u katalitičkoj oksidaciji derivata benzilnog alkohola korištenjem ekološki prihvatljivih oksidansa. Također, proučavat će se i intramolekulska oksidacija alkokso liganda u supramolekulskim spojevima kako bi se ustanovila uloga vanadijevih intermedijera. Cilj projekta je spoznati kako svojstva spojeva ovise o vrsti liganada, nuklearnosti spoja, ili prirodi heteroatoma.Opsežni kvantno-kemijski izračuni, strojno učenje, obrada i analize podataka uz eksperimentalno istraživanje omogućit će razumijevanje odnosa strukture i svojstava te mehanizama reakcija. Na temelju eksperimentalnih podataka, važan rezultat istraživanja predstavljat će model predviđanja, koji će se dalje koristiti kao smjernica za dizajniranje novih materijala s poboljšanim i željenim svojstvima. ]]></summary_hr><summary_en><![CDATA[Interest in coordination-driven supramolecular and hybrid metal-organic assemblies relies not only on their attractive molecular structures but also on their various properties.  In this project, we will therefore address the design of:  (i) vanadium(V) metallocyclic and polymeric assemblies with hydrazone and alkoxo ligands; (ii) hybrids based on Co-macrocations and polyoxovandates or V/Mo-heteropolyoxometalate anions; and (iii) V/Mo-heteropolyoxometalate hybrids covalently functionalized by alkoxo-hydrazone complex assemblies. Each research segment will have interwoven synthetic, physicochemical, and computational aspects. The aim of this project is not only the design of novel assemblies but also the understanding of the cooperative effects and mechanisms that enable their formation, and finally, their specific properties. The in-depth characterisation of the prepared compounds will be crucial for understanding the experimental and computational results of the research.These assemblies will serve as ideal models for testing the catalytic processes and understanding the structure-activity/property relationship. Their role in the catalytic oxidation of benzyl alcohol derivatives using environmentally benign oxidants will be investigated. The intramolecular oxidation of the alkoxo ligand in the supramolecular compounds will also be studied to clarify the role of the vanadium intermediates. The project aims to find out how the properties and performances of the compounds depend on the type of ligands, compound nuclearity, or the nature of the heteroatom. Extensive quantum chemical calculations, machine learning, data processing and analyses will support experimental research and provide structure-properties relationships and mechanistic understanding. Based on the experimental data an important result of the investigation will present a prediction model, which will be further used as a guideline for designing new materials with improved and desired properties. ]]></summary_en></project><project>
<id>15297</id><title_hr><![CDATA[Algoritmi za učinkovitu analizu biomedicinskih vremenskih nizova]]></title_hr><title_en><![CDATA[Algorithms for Efficient Biomedical Time Series Analysis]]></title_en><user_id>12928</user_id><user_firstLast_name>Alan Jović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-8241</code><acronim><![CDATA[ALFABEATS]]></acronim><duration>01.02.2024 - 31.01.2028</duration><status>U tijeku</status><financ_value>162.029,72 eur</financ_value><scie_area_hr>Tehničke znanosti, Biomedicina i zdravstvo, </scie_area_hr><scie_area_en>Technological sciences, Biomedicine and health sciences, </scie_area_en><scie_field_hr>Računarstvo, Kliničke medicinske znanosti, Javno zdravstvo i zdravstvena zaštita, </scie_field_hr><scie_field_en>Computer sciences, Clinical sciences, Public health and health services, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>18915, 6814, 25593, 12932, 865979, 865980, 7560, 24269, 23386, 869511, 872976, </team_members_id><team_members_names><![CDATA[Mario Cifrek, Karla Brkić, Nikolina Frid, Krešimir Jozić, Goran Krstačić, Antonija Krstacic, Domagoj Vidović, Jakša Vukojević, Damir Mulc, Sasa Kendjel, Jana Faber, ]]></team_members_names><keywords_hr><![CDATA[biomedicinski vremenski nizovi, strojno učenje, algoritmi, obrada signala, objašnjiva umjetna inteligencija, web platforma, mobilna aplikacija]]></keywords_hr><keywords_en><![CDATA[biomedical time series, machine learning, signal processing, explainable artificial intelligence, web platform, mobile application]]></keywords_en><summary_hr><![CDATA[Biomedicinski vremenski nizovi (BVN) uključuju elektrokardiogram (EKG), elektroencefalogram (EEG) i mnoge druge. Automatizirana analiza BVN-ova pomoću metoda umjetne inteligencije omogućuje brži i učinkovitiji pristup ispitivanju velikih količina medicinskih podataka. Budući da je donošenje valjanih medicinskih odluka o pacijentima od najveće važnosti u zdravstvu, liječnici bi trebali imati pristup vrijednim programskim rješenjima koja će im pomoći u njihovim zadacima. Trenutačni algoritmi strojnog učenja (uključujući duboko učenje) pate od problema slabe objašnjivosti modela. Projekt ALFABEATS prvenstveno ima za cilj osmišljavanje novih algoritama strojnog učenja za analizu BVN-ova koji se mogu koristiti u medicinskoj praksi. Budući da važne medicinske odluke treba opravdati i objasniti pacijentu, nužno je da modeli strojnog učenja budu objašnjivi. Stoga će algoritmi osmišljeni unutar projekta težiti visokoj točnosti, objašnjivosti i računskoj učinkovitosti. Kako bi se ponudila usluga koja integrira razvijene algoritme, projekt će uključivati razvoj učinkovite i sigurne web platforme i mobilne aplikacije. Programska rješenja nudit će kompletan tok analize BVN-ova. Korišteni modeli ovisit će o potrebnom medicinskom scenariju. Scenariji obuhvaćeni rješenjima uključivat će najmanje pet klinički značajnih zadataka klasifikacije i otkrivanja događaja. I scenarije i programsko rješenje temeljito će vrednovati liječnici uključeni u projektnu skupinu. Anonimizirani skupovi medicinskih podataka na kojima će se algoritmi učiti i testirati bit će organizirani u lokalnoj banci podataka. Skupovi podataka bit će prikupljeni iz besplatno dostupnih internetskih izvora i od lokalnih medicinskih ustanova. Osim unaprjeđenja postojećih znanstvenih spoznaja u biomedicinskom inženjerstvu i računarskoj znanosti, širi utjecaj projekta bit će u razvijenoj programskoj usluzi koja se nudi registriranim liječnicima.]]></summary_hr><summary_en><![CDATA[Biomedical time series (BTS) include electrocardiogram (ECG), electroencephalogram (EEG), and many others. Automated BTS analysis using artificial intelligence methods allows us a faster and more efficient approach to examining large quantities of medical data. Since reaching valid medical decisions about patients is of paramount importance in healthcare, physicians should have access to valuable software solutions to help them with their tasks. Current machine learning (including deep learning) algorithms suffer from the issue of weak explainability of their models. The project ALFABEATS aims primarily at devising novel machine learning algorithms for BTS analysis that can be used in medical practice. Because important medical decisions need to be justified and explained to the patient, it is necessary for the machine learning models to be explainable. Therefore, the algorithms devised within the project will aim at high accuracy, explainability, and computational efficiency. To offer a service that integrates the developed algorithms, the project will include the development of an efficient and secure web platform and a mobile application. The software solutions will offer end-to-end BTS analysis. The used models will depend on the required medical scenario. The scenarios covered by the solutions will include at least five clinically significant classification and event detection tasks. Both the scenarios and the software solution will be thoroughly evaluated by the physicians included in the project group. The anonymized medical datasets on which the algorithms will be trained and tested will be organized in a local databank. The datasets will be acquired from freely available online resources and from local medical institutions. In addition to improving the existing scientific knowledge in biomedical engineering and computer science, the project&#39;s broader impact will be in the developed software service offered to registered physicians.]]></summary_en></project><project>
<id>15299</id><title_hr><![CDATA[Uloga signalnog puta Hedgehog-GLI u komunikaciji tumora i strome posredovanoj faktorima rasta u 2D i 3D tumorskim modelima in vitro]]></title_hr><title_en><![CDATA[The role of Hedgehog-GLI signaling in growth factor-mediated tumor-stroma communication in 2D and 3D in vitro tumor models]]></title_en><user_id>19584</user_id><user_firstLast_name>Maja Sabol</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-6672</code><acronim><![CDATA[HHgrow3D]]></acronim><duration>15.12.2023 - 14.12.2027</duration><status>U tijeku</status><financ_value>188.455,00 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>712, 942, 865071, 866062, 26946, 866092, 25371, 869749, 869985, </team_members_id><team_members_names><![CDATA[Petar Ozretić, Vesna Musani, Josipa Čonkaš, Margita Belušić Gobić, Dinko Leović, Neil Conlon, Dora Raos, Nikolina Vučemilo Paripović, Tea Dragičević, ]]></team_members_names><keywords_hr><![CDATA[signalni putevi, HH-GLI, faktori rasta, sferoidi, komunikacija tumora i strome, tumori]]></keywords_hr><keywords_en><![CDATA[signaling pathways, HH-GLI, growth factors, spheroids, tumor-stroma communication, cancer]]></keywords_en><summary_hr><![CDATA[Signalni put Hedgehog-GLI (HH-GLI) je važan za embrionalni razvoj, dok je u odraslom organizmu utišan, osim u tkivnim matičnim stanicama. Nepravilna hiperaktivacija ovog signalnog puta dovodi do razvoja mnogih tipova tumora, na način da transkripcijski faktori GLI1, GLI2 i GLI3 kontroliraju ekspresiju gena uključenih u proliferaciju, sposobnost metastaziranja te obnavljanje tumorskih matičnih stanica. U našem prethodnom projektu prvi smo proveli sveobuhvatnu analizu transkripcijskih meta sva tri proteina GLI u melanomima, te identificirali veliki broj prethodno poznatih, ali i novih ciljnih gena. Ovim projektom želimo ispitati: (1) koji su faktori rasta pod direktnom kontrolom ovog signalnog puta na modelima tumora jajnika, prostate, te glave i vrata, (2) na koji način se signali prenose među stanicama, (3) kako faktori rasta djeluju na stanice tumora i stanice strome, (4) utječe li relativni omjer stanica tumora i stanica strome na ekspresiju gena u te dvije populacije stanica in vitro, te (5) koji je učinak inhibitora HH-GLI i faktora rasta (pojedinačni i kombinirani) na te dvije populacije stanica.Kako bismo to ispitali koristit ćemo stanične linije, koje ćemo uzgajati u 2D kulturi, ali i u 3D kulturi u obliku sferoida. U oba slučaja također će se koristiti i ko-kulture tumorskih i stromalnih stanica. Rezultati dobiveni tijekom prve tri godine validirat će se na arhivskom materijalu dobivenom iz pacijenata, koji uključuju RNA iz tumora, parafinske rezove, te primarne kulture stanica tumora i strome. Za ispitivanje ovih problema koristit će se niz standardnih molekularno-bioloških metoda (qPCR, Western blot, imunofluorescencija), ali i neke odvedenije metode kao što su hibridizacijski paneli protutijela, RNA-seq te snimanje živih stanica.Ovim projektom razjasnit će se uloga signalnog puta HH-GLI u komunikaciji između stanica tumora i strome, što bi moglo dovesti do usavršavanja kombinirane terapije tumora te otkrića novih prognostičkih biljega.]]></summary_hr><summary_en><![CDATA[The Hedgehog-GLI (HH-GLI) signalling pathway is an important regulator of embryonic development, while it is mostly inactive in the adult organism. It only remains active in somatic stem cells. Aberrant activation of the pathway contributes to tumorigenesis in many tumor types. The GLI1, GLI2 and GLI3 transcription factors regulate gene expression of targets involved in proliferation, metastasis and cancer stem cell renewal. In our previous research we were the first to analyse the transcriptomes of all three GLI proteins in melanoma, and we have identified a large number of target genes, some of them previously known from literature data, but also some novel. In this project, we wish to investigate: (1) which growth factors are directly regulated by HH-GLI signalling on cell models of ovarian, prostate and head and neck cancers, (2) how are the signals transmitted between cells, (3) how do the growth factors affect tumor and stromal cells, (4) does the ratio of tumor to stromal cells affect gene expression in the two populations, (5) what is the effect of HH-GLI and growth factor inhibition (individually or combined) on both populations in vitro.To answer these questions, we will use cell culture models. The cells will be grown in 2D, but also in 3D cultures, as spheroids. In both setups, co-culture of tumor and stromal cells will be used as well. The results from the first three years of the project will then be validated on patient-derived archive material: tumor RNA, paraffin-embedded tissue slides and primary cell cultures of both tumor and stromal origin. We will be using many standard molecular biology techniques (qPCR, Western blot, immunofluorescence), but also some advanced techniques such as protein antibody arrays, RNA-seq and live cell imaging. With this project we will demonstrate the role of HH-GLI signalling in tumor-stroma communication, which could lead to advances in combined tumor therapy and to discovery of new prognostic markers.]]></summary_en></project><project>
<id>15300</id><title_hr><![CDATA[Univerzalnosti u nastajanju u sustavima s jakim međudjelovanjima]]></title_hr><title_en><![CDATA[Emerging universalities in systems with strong interactions]]></title_en><user_id>6532</user_id><user_firstLast_name>Ivan Balog</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-9423</code><acronim><![CDATA[UniSyS]]></acronim><duration>15.01.2024 - 14.01.2028</duration><status>U tijeku</status><financ_value>197.805,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut za fiziku]]></institution_hr><institution_en><![CDATA[Institute of Physics in Zagreb]]></institution_en><team_members_id>865935, 4336, 4933, 954, 4962, 855341, 4380, 866414, 868552, 872312, </team_members_id><team_members_names><![CDATA[Adam Rancon, Osor  Slaven Barišić, Vito Despoja, Antonio Šiber, Zoran Rukelj, Lucija Nora Farkaš, Eduard  Tutiš, GILLES TARJUS, Tomislav Miškić, Lovro Šaravanja, ]]></team_members_names><keywords_hr><![CDATA[funkcionalna renormalizacijska grupa, klase univerzalnosti, fazni prijelazi, rijetki događaji, neuređeni sustavi, kvantni fazni prijelazi, ab-initio]]></keywords_hr><keywords_en><![CDATA[functional renormalization group, universality classes, phase transitions,rare events, disordered systems, quantum phase transitions, ab-initio]]></keywords_en><summary_hr><![CDATA[   Razumijevanje i predviđanje fizikalnih svojstava materijala ogroman je izazov zbog njihove složenosti na molekularnoj, strukturnoj, elektronskoj i spinskoj razini. Postoje dva glavna teorijska pristupa razumijevanju takvih kompleksnih materijala, ovisno o tome rješava li se problem s makroskopskog i) ili mikroskopskog ii) stajališta.   i) Kako je “više drugačije”, od mnogih mikroskopskih sastojaka novonastalo makroskopsko ponašanje vrlo je teško predvidjeti. Ipak, u prirodi se opažaju univerzalna ponašanja a priori vrlo različitih sustava u prirodi. Univerzalnost je tako nađena u vrlo različitim kontekstima, u rasponu problema u statističkoj i čvrstostanjskoj fizici, fizici visokih energija, biofizici i ekonofizici. Za opis ovakvih ponašanja Renormalizacijska grupa je metoda od našeg izbora, jer utjecaje mikroskopskih detalja potiskuje na krupnije prostorne skale, iznjedrujući pri tome efektivne makroskopske modele.   ii) S mikroskopske strane, ab initio računi danas sve brže napreduju. Međutim, za mnoge materijale od suvremenog znanstvenog interesa to je još uvijek nedovoljno. Zato je orijentacija u suvremenim teorijskim istraživanjima kondenzirane tvari ići dalje od uobičajenih aproksimacija, odnosno kombinirati različite metode radi dešifriranja novih kvantnih stanja.   Ovaj projekt ima za cilj iskoristiti oba, i) i ii),  pristupa pri rješavanju različitih problema od trenutnog znanstvenog interesa. To se odražava u njegova dva radna paketa i mnogim specifičnim zadatcima, na temu neuređenih magneta, bozonskih i fermionskih kvantnih sustava te klasičnih bioloških sustava. Problemima će se prići s različitih strana, u skladu sa širokom ekspertizom članova tima iz područja kritičnih ponašanja, faznih prijelaza, biofizike, jakih korelacija, neredu i lokalizaciji. Ovaj  projekt nastavlja tamo gdje je završio prethodni HrZZ-ov projekt IP-2016-06-7258, s najvišom završnom ocjenom. Pri tome, donosi nove perspektive i ideje, zajedno s novim članovima i temama.]]></summary_hr><summary_en><![CDATA[  Understanding and predicting the physical properties of materials is a tremendous challenge, owing to their complexity at the molecular/lattice/structural/electronic/spin levels. There are two main theoretical approaches to understanding such complex materials, depending on whether one is tackling the problem from a macroscopic i) or a microscopic ii) point of view.  i) As &#39;&#39;more is different&#39;&#39;, from many microscopic constituents the emergent macroscopic behavior is tough to predict. A hallmark of emergence is the universal behavior of a priori very different systems found in nature. In particular, universality has been found in various settings, ranging across a wealth of problems in statistical and solid-state physics, high-energy physics, biophysics, and econophysics. The Renormalization Group is the method of our choice to capture such behaviors, tailored to coarse-grain the microscopic details of systems to distill effective, macroscopic models.  ii) From the microscopic side, ab initio calculations are increasingly improving nowadays. However, in many materials of current scientific interest, this proves insufficient. Thus, a major concern in modern theoretical condensed matter research is to go beyond standard approximations and combine different methods to decipher new quantum states.  This project aims to investigate problems of high current interest, relying on both, i) and ii), approaches. This reflects in two work packages and many specific tasks, addressing properties of disordered magnets, boson and fermion quantum systems, as well as classical biological systems. Tasks are attacked by various means, reflecting the broad expertise of team members on critical behaviors, phase transitions, biophysics, strong correlations, disorder, and localization. The current proposal is picking up where the previous HrZZ project IP-2016-06-7258 has finished, marked by the highest final grade. It brings new perspectives and ideas, along with new members and topics.]]></summary_en></project><project>
<id>15301</id><title_hr><![CDATA[Strah divlje svinje od lova: utjecaj na korištenje prostora, stres i kvalitetu mesa]]></title_hr><title_en><![CDATA[Wild boar fear of hunting: effects on space use, stress, and meat quality]]></title_en><user_id>2954</user_id><user_firstLast_name>Nikica Šprem</user_firstLast_name><svouser_id>866103</svouser_id><svouser_firstLast_name>Boštjan Pokorny</svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-7502</code><acronim><![CDATA[WBfearHUNT]]></acronim><duration>12.02.2024 - 11.02.2028</duration><status>U tijeku</status><financ_value>175.942,50 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, Biotehnologija, </scie_field_hr><scie_field_en>Agriculture, Biotechnology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Agronomski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Agriculture]]></institution_en><team_members_id>25076, 22742, 865478, 12615, 23624, 866081, 29062, 865269, 19869, 867519, 872881, 872989, </team_members_id><team_members_names><![CDATA[Andrea Rezić, Nikolina Kelava Ugarković, Stefano Grignolio, Damir Ugarković, Miljenko Konjačić, Oliver Keuling, Tihomir Florijančić, Mihael Janječić, Toni Safner, Valentina Barukčić, Alice Comuzzi, Martina Tunjić, ]]></team_members_names><keywords_hr><![CDATA[Sus scrofa, skupni lov, pojedinačni lov, lovački pas, prostorno ponašanje, stres, GPS telemetrija, DNK metabarkodiranje, kortizol, kvaliteta mesa]]></keywords_hr><keywords_en><![CDATA[Sus scrofa, drive hunt, single hunt, hunting dog, spatial behaviour, stress, GPS telemetry, DNA metabarcoding, cortisol, meat quality ]]></keywords_en><summary_hr><![CDATA[Lov može dovesti do promjena u demografiji, distribuciji, ponašanju i fiziologiji divljih životinja. Osobito kada se provode veliki skupni lovovi s lovačkim psima, mogu izazvati bihevioralne i fiziološke reakcije divljih svinja. Doista, lov može utjecati na prostorno ponašanje, korištenje prostora, ritam aktivnosti, prehrambene navike i izazvati fiziološke reakcije zbog povećanog stresa, što zauzvrat utječe i na dobrobit životinja i na kvalitetu mesa. Znanje o učinku različitih metoda lova na bihevioralne i fiziološke reakcije divljih svinja vrlo je ograničeno. To je posebno izazovno jer vrsta ima veliki potencijal za prijenos bolesti od javnog i gospodarskog značaja. U predloženom projektu, vodeći stručnjaci za divlje svinje u Hrvatskoj, Sloveniji i Švicarskoj razvit će originalni dizajn studije kako bi kombinirali bihevioralne, molekularne i fiziološke podatke, s ciljem razumijevanja ekologije i odgovora divljih svinja izloženih različitim metodama lova. Predloženi projekt pridonijet će boljem razumijevanju učinaka metoda lova na prostorno ponašanje, potencijal rasprostranjenosti i ekologiju kretanja divljih svinja, izloženost stresu kao i na kvalitetu mesa. Bit će to prvi koji će definirati sveobuhvatne interakcije između divljih svinja i lovačkih pasa tijekom lova. Dobiveni rezultati i intenzivne aktivnosti širenja koristit će donositeljima odluka, dionicima, upraviteljima populacije, lovcima i mesnoj industriji kako bi se utvrdile odgovarajuće prakse upravljanja utemeljene na dokazima i znanosti kako bi se smanjili učinci vrlo važnog čimbenika izazivanja stresa i posljedično povećala dobrobit životinja, kao i za dobivanje najkvalitetnijeg mesa za daljnju preradu. Ono što je važno, projekt će biti ugrađen u postojeću Paneuropsku mrežu koja ima za cilj poboljšati širenje informacija o prostornom ponašanju divljih svinja među istraživačima i dionicima, a čemu je tim već pridonio.]]></summary_hr><summary_en><![CDATA[Hunting can lead to changes in the demography, distribution, behaviour and physiology of wildlife. Especially when conducted as large drive hunts with hunting dogs, can cause behavioural and physiological responses of wild boar. Indeed, hunting can affect spatial behaviour, space use, activity rhythms, feeding habits, and cause physiological responses due to increased stress, which in turn affects both animal welfare and quality of meat. Knowledge on the effect of different hunting methods on behavioural and physiological responses of wild boar is very limited. This is particularly challenging as the species has a great potential for transmission of diseases of both public and economic health concern. In the proposed project, leading wild boar experts in Croatia, Slovenia, Switzerland will develop an original study design to combine behavioural, molecular and physiological data, aiming to understand the ecology and responses of wild boar exposed to different hunting methods. The proposed project will contribute to a better understanding of the effects of hunting methods on spatial behaviour, dispersal potential and movement ecology of wild boar, exposure to stress as well as on the meat quality. It will be the first one which will define comprehensive interactions between wild boar and hunting dogs during drive hunts. Results obtained and intensive dissemination activities will benefit decision makers, stakeholders, population managers, hunters, and meet industry to determine appropriate, evidence- and science-based management practices both to decrease effects of a very important stress-inducing factor and consequently increase animal welfare, as well as to obtain the best quality meat for further processing. Importantly, the project will be embedded in existing pan-European networks that aim to improve the dissemination of information on the spatial behaviour of wild boar among researchers and stakeholders, and to which the team has already contributed.]]></summary_en></project><project>
<id>15301</id><title_hr><![CDATA[Strah divlje svinje od lova: utjecaj na korištenje prostora, stres i kvalitetu mesa]]></title_hr><title_en><![CDATA[Wild boar fear of hunting: effects on space use, stress, and meat quality]]></title_en><user_id>2954</user_id><user_firstLast_name>Nikica Šprem</user_firstLast_name><svouser_id>866126</svouser_id><svouser_firstLast_name>Claude Fischer</svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-7502</code><acronim><![CDATA[WBfearHUNT]]></acronim><duration>12.02.2024 - 11.02.2028</duration><status>U tijeku</status><financ_value>175.942,50 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, Biotehnologija, </scie_field_hr><scie_field_en>Agriculture, Biotechnology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Agronomski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Agriculture]]></institution_en><team_members_id>25076, 22742, 865478, 12615, 23624, 866081, 29062, 865269, 19869, 867519, 872881, 872989, </team_members_id><team_members_names><![CDATA[Andrea Rezić, Nikolina Kelava Ugarković, Stefano Grignolio, Damir Ugarković, Miljenko Konjačić, Oliver Keuling, Tihomir Florijančić, Mihael Janječić, Toni Safner, Valentina Barukčić, Alice Comuzzi, Martina Tunjić, ]]></team_members_names><keywords_hr><![CDATA[Sus scrofa, skupni lov, pojedinačni lov, lovački pas, prostorno ponašanje, stres, GPS telemetrija, DNK metabarkodiranje, kortizol, kvaliteta mesa]]></keywords_hr><keywords_en><![CDATA[Sus scrofa, drive hunt, single hunt, hunting dog, spatial behaviour, stress, GPS telemetry, DNA metabarcoding, cortisol, meat quality ]]></keywords_en><summary_hr><![CDATA[Lov može dovesti do promjena u demografiji, distribuciji, ponašanju i fiziologiji divljih životinja. Osobito kada se provode veliki skupni lovovi s lovačkim psima, mogu izazvati bihevioralne i fiziološke reakcije divljih svinja. Doista, lov može utjecati na prostorno ponašanje, korištenje prostora, ritam aktivnosti, prehrambene navike i izazvati fiziološke reakcije zbog povećanog stresa, što zauzvrat utječe i na dobrobit životinja i na kvalitetu mesa. Znanje o učinku različitih metoda lova na bihevioralne i fiziološke reakcije divljih svinja vrlo je ograničeno. To je posebno izazovno jer vrsta ima veliki potencijal za prijenos bolesti od javnog i gospodarskog značaja. U predloženom projektu, vodeći stručnjaci za divlje svinje u Hrvatskoj, Sloveniji i Švicarskoj razvit će originalni dizajn studije kako bi kombinirali bihevioralne, molekularne i fiziološke podatke, s ciljem razumijevanja ekologije i odgovora divljih svinja izloženih različitim metodama lova. Predloženi projekt pridonijet će boljem razumijevanju učinaka metoda lova na prostorno ponašanje, potencijal rasprostranjenosti i ekologiju kretanja divljih svinja, izloženost stresu kao i na kvalitetu mesa. Bit će to prvi koji će definirati sveobuhvatne interakcije između divljih svinja i lovačkih pasa tijekom lova. Dobiveni rezultati i intenzivne aktivnosti širenja koristit će donositeljima odluka, dionicima, upraviteljima populacije, lovcima i mesnoj industriji kako bi se utvrdile odgovarajuće prakse upravljanja utemeljene na dokazima i znanosti kako bi se smanjili učinci vrlo važnog čimbenika izazivanja stresa i posljedično povećala dobrobit životinja, kao i za dobivanje najkvalitetnijeg mesa za daljnju preradu. Ono što je važno, projekt će biti ugrađen u postojeću Paneuropsku mrežu koja ima za cilj poboljšati širenje informacija o prostornom ponašanju divljih svinja među istraživačima i dionicima, a čemu je tim već pridonio.]]></summary_hr><summary_en><![CDATA[Hunting can lead to changes in the demography, distribution, behaviour and physiology of wildlife. Especially when conducted as large drive hunts with hunting dogs, can cause behavioural and physiological responses of wild boar. Indeed, hunting can affect spatial behaviour, space use, activity rhythms, feeding habits, and cause physiological responses due to increased stress, which in turn affects both animal welfare and quality of meat. Knowledge on the effect of different hunting methods on behavioural and physiological responses of wild boar is very limited. This is particularly challenging as the species has a great potential for transmission of diseases of both public and economic health concern. In the proposed project, leading wild boar experts in Croatia, Slovenia, Switzerland will develop an original study design to combine behavioural, molecular and physiological data, aiming to understand the ecology and responses of wild boar exposed to different hunting methods. The proposed project will contribute to a better understanding of the effects of hunting methods on spatial behaviour, dispersal potential and movement ecology of wild boar, exposure to stress as well as on the meat quality. It will be the first one which will define comprehensive interactions between wild boar and hunting dogs during drive hunts. Results obtained and intensive dissemination activities will benefit decision makers, stakeholders, population managers, hunters, and meet industry to determine appropriate, evidence- and science-based management practices both to decrease effects of a very important stress-inducing factor and consequently increase animal welfare, as well as to obtain the best quality meat for further processing. Importantly, the project will be embedded in existing pan-European networks that aim to improve the dissemination of information on the spatial behaviour of wild boar among researchers and stakeholders, and to which the team has already contributed.]]></summary_en></project><project>
<id>15308</id><title_hr><![CDATA[Fragilnost fotosinteze u moru uslijed klimatskih promjena]]></title_hr><title_en><![CDATA[Fragility of marine photosynthesis under climate change]]></title_en><user_id>3031</user_id><user_firstLast_name>Žarko Kovač</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-8859</code><acronim><![CDATA[PHOTOCLIM]]></acronim><duration>31.12.2023 - 30.12.2027</duration><status>U tijeku</status><financ_value>176.481,27 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Interdisciplinarne prirodne znanosti, Fizika, Biologija, </scie_field_hr><scie_field_en>Interdisciplinary natural sciences, Physics, Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Science]]></institution_en><team_members_id>862804, 866071, 2662, 7549, 22701, 866072, 5789, 12559, 866282, 866100, 869755, </team_members_id><team_members_names><![CDATA[Leon Ćatipović, Shubha Sathyendranath, Živana Ninčević Gladan, Davor Mance, Diana Mance, Robert Brewin, Sanda Skejić, Frano Matić, Marin Vojković Vojkovic, Ivona Cetinic Cetinic, Marija Bačeković Koloper, ]]></team_members_names><keywords_hr><![CDATA[morska primarna proizvodnja, stabilnost morskih ekosustava, klimatske prijelomne točke, fragilnost/antifragilnost ekosustava, održivi rast, vrednovanj]]></keywords_hr><keywords_en><![CDATA[marine primary production, ocean ecosystem stability, climate tipping points, ecosystem fragility/antifragility, sustainable growth, ecosystem service]]></keywords_en><summary_hr><![CDATA[Po prvi put u ljudskoj povijesti, antropogene emisije ugljika (10 GtC godišnje) samo su za red veličine niže od produktivnosti Zemljine biosfere (100 GtC godišnje). Polovica produktivnosti odvija se na kopnu, a polovica u moru, unatoč tome što biomasa oceana čini mršavih 1% kopnene biomase. Uz rastuću obalnu populaciju, zahtjevi za produktivnim i zdravim oceanima postaju izraženiji nego ikad. To zahtijeva racionalno upravljanje morskim ekosustavima temeljeno na znanstvenim načelima. Međutim, objektivni i mjerljivi pokazatelji stanja morskih ekosustava koji se mogu prevesti u ekonomske pokazatelje, koji čine temelj racionalnog upravljanja, ne postoje. To je neispravna praksa koja dovodi do potencijalno lošeg upravljanja brojnim morskim ekosustavima diljem svijeta. Ekonomsku vrijednost usluga koje morski ekosustavi pružaju potrebno je objektivno mjeriti, kako u sadašnjosti tako i u budućnosti, kako bi postigli optimalno upravljanje i održivi razvoj. Projekt PHOTOCLIM ima za cilj riješiti ovaj problem preoblikovanjem postojećeg razumijevanja međudjelovanja biologije, fizike i ekonomije u oceanu, počevši od prvih principa. Projekt će primijeniti modernu teoriju kapitala izravno na proučavanje morske primarne proizvodnje (fotosinteze) na biofizičkoj razini te će razviti nove skupove bioekonomskih pokazatelja koji opisuju morske ekosustave. Projekt će kvantificirati fragilnost morske primarne proizvodnje uzrokovanu klimatskim promjenama, popuniti prostorno-vremenske rupe u bioekonomskim pokazateljima korištenjem satelitskih podataka i projicirati buduću fragilnst oceana na klimatskim vremenskim skalama. Projekt predstavlja prvu sustavnu studija morskih ekosustava koja koristi modernu teoriju kapitala ne kao dodatak ekološkoj teoriji, već kao dopunu iste.]]></summary_hr><summary_en><![CDATA[For the first time in human history anthropogenic carbon emissions (10 GtC per year) are just an order of magnitude lower than the productivity of the Earth’s biosphere (100 GtC per year). Half the productivity takes place on land and half at sea, despite the ocean biomass being a meagre 1% of land biomass. With the growing coastal population, demands for productive healthy oceans are increasing. This calls for rational management of ocean ecosystems based on scientific principles. However, objective and quantifiable measures of the ocean ecosystems state that can be translated to economic indicators, the bedrock of rational management, do not exist. This is unsound practice, giving rise to potential mismanagement of numerous ocean ecosystems worldwide. The economic value of ocean ecosystem services needs to be measured objectively, both at present and in the future, to have optimal management and sustainable development. The PHOTOCLIM project aims to address this issue by reforging the current understanding of the interplay between biology, physics and economics in the ocean, starting from first principles. The project will apply modern capital theory directly to the study of marine primary production (photosynthesis) at the biophysical level and will develop new sets of bioeconomic indicators describing ocean ecosystems. The project will quantify climate change induced fragility of marine primary production, fill the space-time gaps in bioeconomic indicators using remote sensing products and project future fragility of the ocean on climate time scales. This will be the first ever systematic study of ocean ecosystems using modern capital theory not as a supplement to ecological theory, but as a complement to it. Project team will collaborate with physical oceanographers, marine biologists, biophysicists, economists and experts in nonlinear systems, stochastic and climate simulations, which will ensure the high interdisciplinary nature of the project.]]></summary_en></project><project>
<id>15310</id><title_hr><![CDATA[Digitalizacija u poduzetništvu u kontekstu odgovora na egzogeni šok: Pokretači, prepreke i utjecaj na otpornost poduzeća]]></title_hr><title_en><![CDATA[Digitalization in entrepreneurship in the context of response to an exogenous shock: Drivers, barriers and impact on firm resilience]]></title_en><user_id>1287</user_id><user_firstLast_name>Marina Klačmer Čalopa</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-6703</code><acronim><![CDATA[DigEntre]]></acronim><duration>18.12.2023 - 17.12.2027</duration><status>U tijeku</status><financ_value>119.449,81 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, </scie_field_hr><scie_field_en>Economy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet organizacije i informatike]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Organization and Informatics]]></institution_en><team_members_id>861615, 27134, 27084, 13419, 861485, 27106, 25684, 861590, 19936, 861535, 861597, 867644, 27101, 866666, 867643, 872415, 870816, </team_members_id><team_members_names><![CDATA[Marijana Bubanić, Kristina Detelj, Ivana Đunđek Kokotec, Mirjana Grčić Fabić, Iva Gregurec Gregurec, Suzana Keglević Kozjak, Irena Konecki, Dina Korent, Mihaela Mikić, Vlatka Škokić, Ksenija Vuković, Zrinka Lacković Vincek, Karolina Kokot, Ivana Dvorski Lacković, Vladimir Kovšca, Ivona Kocijan, Ana Novak, ]]></team_members_names><keywords_hr><![CDATA[digitalizacija, digitalna transformacija, mala i srednja poduzeća, otpornost, ranjivost, COVID-19 kriza, Hrvatska]]></keywords_hr><keywords_en><![CDATA[digitalization, digital transformation, small and medium-sized companies, resilience, vulnerability, COVID-19 crisis, Croatia]]></keywords_en><summary_hr><![CDATA[Temeljna svrha istraživanja je dobiti odgovore na pitanja koji su se dijelovi hrvatske prerađivačke industrije i sektora trgovine i turizma pokazali najotpornijima odnosno najranjivijima tijekom krize COVID-19 i u čemu se ranjivost očituje. Specifični cilj projekta je ispitati jesu li i kako na otpornost poduzeća utjecale promjene u stupnju digitalizacije te koja su obilježja poduzeća koja su iskoristila krizu kao priliku kroz implementaciju digitalnih poslovnih modela, uvođenje novih kanala distribucije i razvoj proizvoda i usluga podržanih digitalnom tehnologijom. Šire, ispituje se koji faktori na razini industrije, poduzeća i poduzetnika u tri hrvatska sektora djeluju kao pokretači digitalizacije, a koji je obuzdavaju. Unutar odabranih djelatnosti fokus se usmjerava na mikro, mala i srednja hrvatska poduzeća kao najranjivije dijelove gospodarstva. Metodološki okvir za provedbu istraživanja uključuje longitudinalno kvantitativno istraživanje nad sekundarnim podacima za sedamnaestogodišnje razdoblje (2008-2024.), anketno istraživanje te kvalitativno istraživanje uz primjenu metode fenomenologije. Rezultati projekta reflektirat će se u objavi 13 radova u zbornicima međunarodno priznatih znanstvenih skupova te 8 A1 znanstvenih radova u časopisima indeksiranim u bazama WoSCC i/ili Scopus. Znanstveni doprinos projekta očituje se u razvijenom korpusu novog znanja o dihotomiji profila ranjivih i otpornih poduzeća. Također, obogatit će se još uvijek oskudno znanje o uzročno-posljedičnim vezama na relaciji digitalizacija - performanse poduzeća te će se doprinijeti izoštravanju spoznaja o pokretačima i preprekama digitalizacije. S aplikativnog aspekta znanje razvijeno u sklopu projekta bit će vrijedna baza za dizajniranje politika usmjerenih jačanju otpornosti poduzeća, te za unaprjeđenje i provedbu nacionalnog plana za digitalnu transformaciju gospodarstva, a sukladno naporima artikuliranim tzv. digitalnim kompasom digitalnog desetljeća EU-a.]]></summary_hr><summary_en><![CDATA[The basic purpose of the research is to get answers to the questions which parts of the Croatian manufacturing industry and the trade and tourism sectors have proven to be the most resilient or vulnerable during the COVID-19 crisis and in which vulnerability is manifested. The specific goal of the project is to examine whether and how changes in the degree of digitalization have affected the resilience and what are the characteristics of companies that used the crisis as an opportunity through the implementation of digital business models, the introduction of new distribution channels and the development of products and services supported by digital technology. Broadly, it examines which factors at the level of industry, companies and entrepreneurs in three Croatian sectors act as drivers of digitalization, and which restrain it. The focus is on micro, small and medium-sized Croatian companies as the most vulnerable parts of the economy. The methodological framework includes longitudinal quantitative research for the period 2008-2024, survey research and qualitative research. The project results are: publication of 13 papers in internationally scientific meetings proceedings and 8 A1 scientific papers in journals indexed in WoSCC and/or Scopus. The scientific contribution of the project is developed body of new knowledge about the dichotomy of the profile of vulnerable and resilient companies. Also, the still scarce knowledge about cause-and-effect relationships in relation to digitalization - company performance will be enriched and will contribute to sharpening knowledge about drivers and obstacles to digitalization. Applicative, the developed knowledge will be valuable for designing policies aimed at strengthening the resilience of companies, and for the improvement and implementation of the national plan for the digital transformation of the economy, and in accordance with the efforts articulated with the so-called digital compass of the EU&#39;s digital decade.]]></summary_en></project><project>
<id>15313</id><title_hr><![CDATA[&#39;&#39;Where East meets West&#39;&#39;: Putopisni narativi i stvaranje slike o umjetničkoj baštini Dalmacije u modernoj Europi (c. 1675 - c. 1941)]]></title_hr><title_en><![CDATA[&#39;&#39;Where East meets West&#39;&#39;: Travel narratives and the fashioning of a Dalmatian artistic heritage in modern Europe (c. 1675 – c. 1941)]]></title_en><user_id>3905</user_id><user_firstLast_name>Ana Šverko</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-8676</code><acronim><![CDATA[TraveloguesDalmatia]]></acronim><duration>18.12.2023 - 17.12.2027</duration><status>U tijeku</status><financ_value>105.864,47 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Povijest umjetnosti, Filologija, Povijest, Znanost o umjetnosti, </scie_field_hr><scie_field_en>Art history, Philology, History, Arts, </scie_field_en><institution_hr><![CDATA[Institut za povijest umjetnosti]]></institution_hr><institution_en><![CDATA[Institute of Art History, Zagreb]]></institution_en><team_members_id>605, 27273, 12328, 4910, 5027, 3151, 866139, 6665, 866149, 871380, </team_members_id><team_members_names><![CDATA[Mateo Bratanić, Sanja Žaja Vrbica, Marko Špikić, Irena Kraševac, Cvijeta Pavlović, Sandra Križić Roban, Wittich Elke Katharina, Josip Belamarić, Katrina O&amp;#39;Loughlin O&amp;#39;Loughlin, Petar Strunje, ]]></team_members_names><keywords_hr><![CDATA[putovanje, putopisni narativi, putopisi, putopisni žanr, Grand Tour, ženski putopisi, Dalmacija, Hrvatska, moderna Europa, srednjoistočna Europa, umje]]></keywords_hr><keywords_en><![CDATA[travel, travel narratives, travelogue, travel writing, Grand Tour, women travel, Dalmatia, Croatia, modern Europe, East-Central Europe, art, architect]]></keywords_en><summary_hr><![CDATA[Projektni prijedlog se nadovezuje na rezultate HRZZ-ova projekta Dalmacija kao odredište europskog Grand Toura u 18. i 19. stoljeću, prvog u Hrvatskoj koji je ravnopravno analizirao tekstualne i vizualne putopisne narative. Ovaj se projekt fokusira na promjenu uloge putopisa – s deskripcije prostora na interpretaciju umjetničke baštine Dalmacije – u razdoblju popularizacije i internacionalizacije putopisnog žanra. Počiva na hipotezi da se formiranje slike o dalmatinskoj umjetničkoj baštini u europskom imaginariju ne može razumjeti ako se interdisciplinarno i komparativno ne sagleda širok raspon putopisnih narativa koji su zajedno pridonijeli njezinu oblikovanju. Putopisi su uvelike formirali europski identitet Dalmacije na interpretaciji umjetničke baštine zahvaljujući geografsko-političkoj poziciji na granici Istoka i Zapada, na kojoj su doticaji kršćanskih i islamskih duhovnih pojaseva ostajali zabilježeni u umjetničkom stvaralaštvu. Znanstvena istraživanja uloge putopisa u tumačenju kulturnog identiteta nekog područja na svjetskoj se razini sustavno razvijaju, dok suvremena historiografija kritički revidira heteropredodžbe i autopredodžbe o povijesti umjetnosti srednjoistočne Europe. Stoga u znanstvenom utvrđivanju doprinosa putopisnih narativa pozicioniranju dalmatinske umjetničke baštine u europskoj perspektivi, kao pretpostavci za kritičku reviziju te pozicije, nalazimo teorijsku i historiografsku relevantnost projekta za europsku povijest umjetnosti i druge humanističke discipline, ali i za izgradnju suvremenog hrvatskog kulturnog identiteta. Naredna je hipoteza da je putopis autonomna multidisciplinarna i multimedijska praksa, što u hrvatskom znanstvenom diskursu nije još posve usaglašeno s međunarodnim dosezima. Predlaže se stoga proširenje kategorije putopisa u skladu sa suvremenom metodologijom na putničko iskustvo izloženo u različitim medijima, što je aktualna tema na svjetskoj razini. Pritom se po prvi put sustavno istražuju ženski putopisni narativi. ]]></summary_hr><summary_en><![CDATA[This project proposal develops the results of the CSF project Dalmatia as a Destination of the European Grand Tour in the 18th and the 19th Century; the first in Croatia to analyse textual and visual travelogues on an equal footing. We will focus on a shift in the role of travelogues—from describing spaces, to interpreting the artistic heritage of Dalmatia—in a period that saw the popularisation and internationalisation of the travel genre. Our work builds on the hypothesis that the image of Dalmatian artistic heritage that formed in the European imagination cannot be understood without comparative investigation of travel narratives. Travelogues played a significant role in the formation of Dalmatia’s European identity and artistic heritage thanks to the region’s geopolitical position on the border between East and West. The resulting contact between the Christian and Islamic worlds was recorded in Dalmatian art. Scholarly research that considers travelogues as testimonials of the cultural identity has been developing systematically worldwide. Contemporary historiography, meanwhile, is critically re-examining heterostereotypes and autostereotypes about the artistic heritage of Central Eastern Europe. This project therefore has theoretical and historiographic relevance for European art history and other humanities, as well as for a contemporary Croatian cultural identity. We locate this relevance in the establishment of the contribution that travelogues made to the positioning of Dalmatian artistic heritage in a European context, as well as in the assumption that a critical revision of this position is required. Our next hypothesis is that the travelogue is an autonomous multidisciplinary and multimedia practice, and it has yet to be fully elaborated in Croatian scholarship in line with current international research. This project will expand the category of the travelogue to incorporate various media, and include the first systematic study of women’s travelogues.]]></summary_en></project><project>
<id>15314</id><title_hr><![CDATA[Reprezentacija, razvoj, edukacija, participacija – umjetnost u društvu od 19. do 21. stoljeća]]></title_hr><title_en><![CDATA[Representation, Development, Education, Participation – Art in Society in 19th – 21st Centuries]]></title_en><user_id>3499</user_id><user_firstLast_name>Dragan Damjanović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-9843</code><acronim><![CDATA[ARTINS]]></acronim><duration>18.12.2023 - 17.12.2027</duration><status>U tijeku</status><financ_value>119.450,52 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Povijest umjetnosti, </scie_field_hr><scie_field_en>Art history, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>23307, 865952, 865209, 23503, 865892, 4416, 4446, 4143, 4554, 23276, 23484, 5489, 27273, 872983, </team_members_id><team_members_names><![CDATA[Josipa Alviž, Lidija Butković Mićin, Sanja Delić, Ivan Kokeza, Julija Lozzi Barković, Silvija Lučevnjak, Lovorka Magaš Bilandžić, Željka Miklošević, Jasminka Najcer Sabljak, Jasmina Nestić, Patricia Počanić, Dalibor Prančević, Sanja Žaja Vrbica, Ana-Marija Senfner, ]]></team_members_names><keywords_hr><![CDATA[Povijest umjetnosti, Umjetnost XIX. stoljeća, Umjetnosti XX. stoljeća, Umjetnost i društvo, muzeji, baština, identiteti]]></keywords_hr><keywords_en><![CDATA[Art History, 19th Century Art, 20th Century Art, Art and Society, Museums, Heritage, Identities]]></keywords_en><summary_hr><![CDATA[Projekt “Reprezentacija, razvoj, edukacija, participacija – umjetnost u društvu od 19. do 21. stoljeća” istraživat će različite aspekte umjetničke produkcije i prezentacije umjetnosti od početka 19. stoljeća do danas na području Hrvatske. To je razdoblje obilježeno velikim promjenama u ustrojstvu društva koje su redovito imale (i imaju i danas) utjecaj na umjetnost, ne samo u smislu da se odražavaju na formalnim karakteristikama djela vizualnih umjetnosti, nego se i njihova forma i sadržaj koriste za postizanje društvenih ciljeva, kako na razini specifičnih zajednica tako i društva u cjelini. Ovim se projektom nastoji na prvom mjestu upotpuniti istraživanja koja odražavaju usmjerenje u umjetničkoj teoriji i praksi prema društvenoj povijesti i društvenoj sadašnjosti, a koja su u hrvatskom istraživačkom prostoru povijesti umjetnosti i vizualnih komunikacija tek djelomično istražena. Promjene koje su se dogodile u odnosu umjetnosti i društva u navedenome razdoblju proučavat će se kroz četiri podteme: 1) kroz način na koji je oblikovan prostor i identitet zajednica, 2) kroz istraživanja uloga umjetnosti u razvoju društvenog standarda, 3) kroz istraživanje pristupa edukaciji o umjetnosti i putem umjetnosti na razini društva i specifičnih zajednica, i naposljetku 4) kroz istraživanje suradničkih odnosa u produkciji i komunikaciji umjetnosti. Istraživački tim čini 14 znanstvenika koji rade na svim sveučilištima u Hrvatskoj na kojima se predaje povijest umjetnosti te u dvama muzejima. Riječ je o istraživačima specijaliziranim za raznolike teme vezane uz povijest umjetnosti Hrvatske 19., 20. i 21. stoljeća: slikarstvo, kiparstvo, arhitekturu, vizualne komunikacije, povijest povijesti umjetnosti, muzeologiju i slično. Trećinu tima (5 istraživača) čine mlađi znanstvenici za čiji formativni razvoj projekt može imati odlučujuću ulogu. Tijekom realizacije projekta planira se zapošljavanje jednog doktoranda. ]]></summary_hr><summary_en><![CDATA[The project &#39;&#39;Representation, Development, Education, Participation - Art in Society in 19th – 21st centuries&#39;&#39; will explore different aspects of artistic production and presentation of art from the beginning of the 19th century to the present day in Croatia. This period was marked by major structural changes in society that regularly had (and still have) an impact on art, not only in the sense that they are reflected in the formal characteristics of art works and architecture, but also that their form and content have been used to achieve social goals, both at the level of specific communities and society as a whole. The aim of the project is to expand on the research that are based on artistic theory and practice of social history and the social present, which in the Croatian research area of the history of art and visual communications has only been partially investigated. The changes that took place in the relationship between art and society in the mentioned period will be studied through four objectives: 1) through the way in which the space and identity of communities were shaped, 2) through research into the role of art in the development of social standards, 3) through research into approaches to education about art and through art at the level of society and specific communities and finally 4) through research of collaborative relationships in the production and communication of art. The project team comprises 14 researchers working at all Croatian universities where art history is taught and at two museums. They all specialize in various topics related to the Croatian art history in period from the 19th to the 21st century: painting, sculpture, architecture, visual communication, history of art history and, museology. One third of the team (5 researchers) is made up of young researchers for whose development this project can be of utmost importance. During the implementation of the project, it is planned to employ one PhD student.]]></summary_en></project><project>
<id>15317</id><title_hr><![CDATA[Istraživanja aminoacil-tRNA-sintetaza kao antibiotskih meta i mehanizama kojima razvijaju rezistenciju]]></title_hr><title_en><![CDATA[Investigation of aminoacyl-tRNA syntetases as targets for antibiotics and how they develop resistance mechanisms]]></title_en><user_id>7711</user_id><user_firstLast_name>Ita Gruić Sovulj</user_firstLast_name><svouser_id>14844</svouser_id><svouser_firstLast_name>Nenad Ban</svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-1400</code><acronim><![CDATA[ARSTARE]]></acronim><duration>01.03.2024 - 29.02.2028</duration><status>U tijeku</status><financ_value>194.040,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, Biologija, </scie_field_hr><scie_field_en>Chemistry, Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>19864, 20026, 24302, 24303, 865928, 27031, 866095, 868758, 870249, </team_members_id><team_members_names><![CDATA[Marko Močibob, Morana Dulić, Igor Živković, Marija Pranjić, Petra Kozulić, Jeff Errington, Yousef Dashti, Robert Pendelić, Karla Peranić, ]]></team_members_names><keywords_hr><![CDATA[aminoacyl-tRNA synthetases, antimicrobials, antibiotic resistance, protein evolution, tRNA recognition]]></keywords_hr><keywords_en><![CDATA[aminoacyl-tRNA synthetases, antimicrobials, antibiotic resistance, protein evolution, tRNA recognition]]></keywords_en><summary_hr><![CDATA[Sinteza proteina (translacija) središnji je biološki proces, učestalo inhibiran prirodnim i sintetskim antibioticima. Presudnu ulogu u translaciji imaju aminoacil-tRNA-sintetaze (AARS) koje povezuju aminokiseline s pripadnim tRNA za potrebe translacije na ribosomu. Pokazano je da su AARS dobre mete za razvoj antibiotika, a mupirocin kao inhibitor izoleucil-tRNA-sintetaze posjeduje odobrenje regulatornih agencija. U današnje vrijeme otkrivanje novih antibiotika je usporeno, dok pojava antibiotske rezistencije raste do alarmantnih razmjera. Stoga ovaj prijedlog projekta teži otkrivanju novih antibiotika iz skupine prirodnih spojeva usmjerenih na AARS. Za tu svrhu razvit ćemo novi stanični test za pretraživanje knjižnica prirodnih spojeva ili sirovih ekstrakata. Izolirat ćemo potencijalne antibiotike i ispitati mehanizam njihovog djelovanja na ciljnu sintetazu s kinetičkih i strukturnih aspekata. Istražit ćemo prirodne varijacije očuvanih motiva unutar aktivnog mjesta AARS i poveznicu s antibiotskom rezistencijom, te evolucijske prednosti takvih prirodnih varijacija. Proučavat ćemo osobitosti bakterijskih i eukariotskih AARS da bismo razjasnili osnove selektivnosti spram enzima patogena i humanih enzima. Prijedlog projekta temelji se na snažnoj suradnji glavnog prijavitelja (prof. Ita Gruić Sovulj) s velikim iskustvom u području reakcijskih mehanizama i biokemije AARS, prof. Nenada Bana (suprijavitelj s ETH Zürich) - vodećim ekspertom u strukturnoj biologiji translacije i prof. Jeffa Erringtona (suradnika s University of Sydney), svjetski priznatog bakterijskog genetičara i eksperta za prirodne spojeve kao terapeutike. Suradnja s eminentnim inozemnim znanstvenicima doprinijet će razvoju znanstvene izvrsnosti na Sveučilištu u Zagrebu i snažno će utjecati na znanstveno usavršavanje dva poslijedoktoranda i tri doktoranda koji će biti angažirani na projektu, te će pogodovati prijenosu vještina iz strukturne biologije i razvoja lijekova u Hrvatsku.]]></summary_hr><summary_en><![CDATA[Protein synthesis (translation) is a central biological process often targeted by natural and man-made antibiotics. Aminoacyl-tRNA synthetases (AARS) are key players that link a particular amino acid to its cognate tRNAs for delivery to the ribosome. AARSs are validated as good antibiotic targets, and mupirocin that inhibits isoleucyl-tRNA synthetase has been approved by FDA. The discovery of novel antibiotics occurs at a slow pace while antibiotic resistance increases rapidly. This contributes to the alarming situation in global health. Thus, this proposal aims to discover novel AARS-targeting antibiotics from the pool of natural products. In doing so, we will develop a new cell-based reporter assay for screening natural product libraries or crude extracts. The promising antibiotic(s) will be isolated and the mode of action against the target AARS kinetically and structurally examined. The evolutionary advantages of the natural variations in the most conserved motifs of AARS active sites and the link between these variations and antibiotic resistance will be explored. AARS bacterial- and eukaryote-specific features will be studied to understand the basis of selectivity for pathogen vs human enzymes. The proposal relies on strong collaborations of the main applicant (prof Ita Gruic Sovulj), highly experienced in the reaction mechanisms and biochemistry of AARSs, with prof. Nenad Ban (co-Applicant from ETH Zurich), a leading world expert in the structural biology of translation, and prof. Jeff Errington (a collaborator from the University of Sydney), a worldwide recognized bacterial geneticist also experienced in natural product therapeutics. Collaboration with such eminent scientists will promote scientific excellence at the University of Zagreb, strongly influence the scientific upbringing of two postdocs and three Ph.D students engaged with the project and bring novel expertise in structural biology and drug development to Croatia. ]]></summary_en></project><project>
<id>15318</id><title_hr><![CDATA[Pouzdane metode za proračun aluminijskih konstrukcija koje odgovaraju zahtjevima budućnosti]]></title_hr><title_en><![CDATA[REliable design methods for ALuminium structures fit for the future requirements]]></title_en><user_id>369</user_id><user_firstLast_name>Davor Skejić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-9298</code><acronim><![CDATA[REAL-fit]]></acronim><duration>18.12.2023 - 17.12.2027</duration><status>U tijeku</status><financ_value>155.683,85 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Interdisciplinarne tehničke znanosti, Građevinarstvo, Strojarstvo, Temeljne tehničke znanosti, </scie_field_hr><scie_field_en>Interdisciplinary technological sciences, Civil engineering, Mechnical engineering, Basic engineering sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Građevinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Civil Engineering]]></institution_en><team_members_id>24476, 21350, 855305, 865827, 27283, 2806, 2798, 865899, 22521, 873008, </team_members_id><team_members_names><![CDATA[Ivan Lukačević, Ivan Ćurković, Ivan Čudina, Anđelo Valčić, Ana Skender, Ivica Garašič, Darko Landek, Mislav Štefok, Tihomir Dokšanović, Marko Antić, ]]></team_members_names><keywords_hr><![CDATA[aluminijske konstrukcije, robotsko zavarivanje, Eurokod 9, pouzdanost, Direktna metoda proračuna, optimizacija, analiza životnog ciklusa, održivost]]></keywords_hr><keywords_en><![CDATA[aluminium structures, robotic welding, Eurocode 9, reliability, Direct Design Method, optimisation, life-cycle analysis, sustainability]]></keywords_en><summary_hr><![CDATA[Iako konstrukcijske aluminijske legure obiluju prednostima u odnosu na druge građevinske materijale (mala vlastita težina, korozijska otpornost, 100% mogućnost reciklaže), uz njih se vežu pretežito konzervativne proračunske metode dane u Eurokodu 9. Konzervativne redukcije mehaničkih svojstava aluminija u zoni zavarenog spoja imaju za posljedicu izbjegavanje upotrebe zavarenih elemenata što značajno ograničava primjenu aluminija u nosivim građevinskim konstrukcijama. Naime, kod konstrukcija većih raspona nužne su velike dimenzije elemenata koji se ne mogu proizvesti istiskivanjem. Nadalje, uporaba istisnutih aluminijskih elemenata ne omogućuje racionalizaciju utroška materijala kao što se to može ostvariti zavarenim elementima promjenjive visine koji se ciljano oblikuju prema funkciji u konstrukcijskom sustavu. U tom smislu, projekt REAL-fit predlaže sveobuhvatna interdisciplinarna istraživanja mogućnosti primjene inovativnih tehnologija robotske proizvodnje i pouzdanih metoda proračuna aluminijskih zavarenih elemenata, priključaka i čitavih konstrukcijskih sustava. Planirani razvoj optimiziranog postupka robotskog zavarivanja biti će baza za istraživanje konstrukcijskog ponašanja zavarenih aluminijskih elemenata i priključaka nosač-stup. Osim eksperimentalnih i numeričkih metoda, u istraživanju će se koristi probabilističke metode. Probabilističke analize na II. razini omogućit će znanstveno argumentirano poboljšanje proračunskih postupaka danih u europskim normama za proračun aluminijskih konstrukcija. Nadalje, izazovi primjene aluminijskih legura u građevinarstvu rješavat će se holističkim pristupom koji integrira naprednu Direktnu metodu proračuna konstrukcija s metodama procjene životnog ciklusa i analize troškova životnog ciklusa. Upravo to je jedan od krajnjih ciljeva projekta s kojim će se vrednovati pouzdanost i održivost ekonomičnih aluminijskih konstrukcija tijekom cijelog životnog vijeka.]]></summary_hr><summary_en><![CDATA[Although structural aluminium alloys have many advantages compared to other construction materials (low self-weight, corrosion resistance, 100% recyclable), they are associated with predominantly conservative design methods given in Eurocode 9. Conservative reductions of aluminium mechanical properties in the welded connection zone have the effect of avoiding the use of welded members, which significantly limits the use of aluminium in load-bearing structures. This is because structures with larger spans require large dimensions of the members, which cannot be produced by extrusion. Moreover, the use of extruded aluminium members does not allow for rationalisation of material consumption, as can be achieved with welded tapered members that are specifically shaped according to their function in the structural system. In this sense, the REAL-fit project proposes comprehensive interdisciplinary research on the possibility of applying innovative robotic production technologies and reliable design methods for aluminium welded members, joints, and entire structural systems. The planned development of an optimised robotic welding process will form the basis for research into the structural behaviour of welded aluminium members and beam-to-column joints. In addition to experimental and numerical methods, probabilistic methods will also be used in the research. 2nd order probabilistic analyses will enable a scientifically based improvement of the design procedures given in the European norms for the design of aluminium structures. Furthermore, the challenges of the application of aluminium alloys in construction will be solved with a holistic approach that integrates the advanced Direct Design Method of structural design with the methods of life-cycle assessment and life-cycle cost analysis. This is precisely one of the ultimate goals of the project, which will evaluate the reliability and sustainability of economic aluminium structures throughout their life cycle.]]></summary_en></project><project>
<id>15321</id><title_hr><![CDATA[Potencijal i perspektiva restauracije Europske plosnate kamenice u Jadranskom moru]]></title_hr><title_en><![CDATA[Potential and Perspective of Native Oyster Restoration in the Adriatic Sea ]]></title_en><user_id>670</user_id><user_firstLast_name>Daria Ezgeta Balić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-5258</code><acronim><![CDATA[POPOyster]]></acronim><duration>31.12.2023 - 30.12.2027</duration><status>U tijeku</status><financ_value>141.775,83 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, Interdisciplinarne prirodne znanosti, </scie_field_hr><scie_field_en>Biology, Interdisciplinary natural sciences, </scie_field_en><institution_hr><![CDATA[Institut za oceanografiju i ribarstvo]]></institution_hr><institution_en><![CDATA[Institute of Oceanography and Fisheries]]></institution_en><team_members_id>3031, 29294, 3958, 3959, 669, 866087, 866121, 866219, 7025, 868401, 872301, 2904, </team_members_id><team_members_names><![CDATA[Žarko Kovač, Luka Žuvić, Dubravka Bojanić Varezić, Nika Stagličić, Barbara Zorica, Elizabeta Briski, Eve Galimany Sanroma, Ivana Marušić, Nedo Vrgoč, Niko Bujas, Ratko Cvitanić, Ivana Prusina Conde, ]]></team_members_names><keywords_hr><![CDATA[Ostrea edulis, ekologija ishrane kamenice,  reprodukcija kamenice, distribucija ličinki, restauracija staništa kamenice]]></keywords_hr><keywords_en><![CDATA[Ostrea edulis, oyster feeding ecology, oyster reproduction, larvae distribution, oyster habitat restoration]]></keywords_en><summary_hr><![CDATA[U Europi stanje naselja kamenice klasificira se kao loše ili su čak funkcionalno nestale. U slučaju plosnate kamenice O. edulis, to je rezultat sinergijskog učinka visoke stope smrtnosti uzorkovane parazitom  Bonamia ostreae i prekomjernog izlova. S obzirom da kamenice tvore biogene grebene koji imaju važnu ulogu u funkcioniranju ekosustava, u posljednja dva desetljeća uloženo je mnogo napora kako bi se obnovile prirodne populacije i staništa kamenica u svijetu. Iako je na nekim područjima O. edulis potpuno nestala, ova vrsta je još uvijek prisutna u  Jadranu. Međutim, nedavni podaci pokazuju da se brojnost O. edulis u sjevernom Jadranu značajno smanjila tijekom posljednjeg desetljeća. Iako nas činjenica da je ova vrsta još uvijek prisutna u prirodnim populacijama stavlja u pogodniji položaj u usporedbi s drugim regijama, postoji značajni nedostaci o istraživanju prirodnih populacija ove vrste u Jadranu. Stoga POPOyster projekt predstavlja prvu sveobuhvatnu akciju u Jadranskom moru s ciljem identificiranja novih i relevantnih bioloških i ekoloških podataka o prirodnim populacijama O. edulis potrebnih za buduće mjere očuvanja i obnove.POPOyster je multidisciplinarni projekt koji uključuje osnovna biološka istraživanja, ekološke eksperimente, molekularnu biologiju, ribarstvo, fizičku oceanografiju, ekološko modeliranje i znanost o materijalima. Stoga se projekt POPOyster može smatrati prvim korakom prema obnovi prirodnih populacija kamenica u istočnom Jadranu.Ciljevi će se postići:-	analizom trenutnog stanja kamenica u sjevernom Jadranu; -	analizom bioloških i ekoloških svojstava kao što su reprodukcija i ekologija ishrane O. edulis iz prirodne populacije i njihovih ovisnosti o okolišnim čimbenicima; -	analizom strukture hranidbene mreže i trofičkih odnosa s naglaskom na kamenicu O. edulis-	unaprjeđivanjem znanja o prikladnim podlogama za naseljavanje mlađi kamenice.Rezultati projekta bit će objavljeni u šest znanstvenih radova.]]></summary_hr><summary_en><![CDATA[In the European ecoregion, the status of oyster reefs is described as poor or even functionally extinct. In the case of European flat oyster Ostrea edulis, decline is a result of the synergistic effect of the high mortality rate observed in O. edulis due to overfishing and a parasitic disease bonamiosis. Since oysters form biogenic reefs and play an important ecological role in the ecosystem functioning, in the last two decades, significant efforts have been made to restore the native oyster populations and their habitats. Although, O. edulis vanished entirely in some areas, it is still present in the Adriatic. However, recent data also showed that O. edulis abundance in the northern Adriatic decreased significantly during the last decade. Despite having the advantage over other regions, as O. edulis is still present in natural populations, there is a lack of research on natural population of this species in the eastern Adriatic. POPOyster project will serve as a first holistic action in the Adriatic Sea aimed to identify new and relevant biological and ecological data about natural populations of O. edulis necessary for future conservation and restoration measures. POPOyster is a highly multidisciplinary project that includes basic biological research, ecological experiments, molecular biology, fisheries, physical oceanography, ecological modelling, and material science. Therefore, POPOyster can be considered a first step toward restoring natural oyster populations in the eastern Adriatic. This will be achieved by: -analysing the current status of oyster beds in the northern Adriatic; -analysing biological and ecological traits such as reproduction and feeding ecology of O. edulis from natural population and related environmental parameters; -analysing the food web structure and trophic interactions of O. edulis;-improve knowledge about suitable substrates for oyster settlement.Project results will be published in six scientific papers.]]></summary_en></project><project>
<id>15322</id><title_hr><![CDATA[Senzor staničnog stresa NKG2D – uloga u neuroinflamatornom poremećaju]]></title_hr><title_en><![CDATA[Cellular stress sensor NKG2D – role in driving neuroinflammation]]></title_en><user_id>4980</user_id><user_firstLast_name>Marina Babić Čač</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-5906</code><acronim><![CDATA[STRESS-IN]]></acronim><duration>18.12.2023 - 17.12.2027</duration><status>U tijeku</status><financ_value>199.037,96 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Medicine]]></institution_en><team_members_id>4958, 865929, 5357, 869781, 19748, </team_members_id><team_members_names><![CDATA[Astrid Krmpotić, Chiara Romagnani, Daria Kveštak, Lucija Mušak, Inga Kavazović, ]]></team_members_names><keywords_hr><![CDATA[Imunološki sistem, urođena imunost, CD4+ limfociti T, NKG2D, središnji živčani sustav, upala SŽS-a, urođeni receptori, senzori staničnog stresa ]]></keywords_hr><keywords_en><![CDATA[Immunity, innate immunity, CD4+ T cells, NKG2D, CNS, neuroinflammation, innate lymphocyte sensors, cellular stress sensors ]]></keywords_en><summary_hr><![CDATA[Multipla skleroza (MS) je bolest središnjeg živčanog sustava posredovana imunim odgovorom te ju karakterizira upala, demijelinacija i gubitak oligodendrocita te ozljeda aksona. MS se smatra vodećim uzrokom neutraumatskih neuroloških poremećaja u 2.5 milijuna mladih ljudi u sjevernoj Americi i Europi, u kojih se bolest razvija u dobi od 20 do 50 godina. Iako su uzroci MS još uvijek nepoznati, pored genetičke predispozicije, opisani su mnogi okolišni utjecaji, kao što je nedostatak vitamina D, debljina, pušenje te infekcija Epstein Barr virusom, koji mogu utjecati na razvoj bolesti.U podlozi razvoja multiple skleroze, kao i u mišjem modelu eksperimentalnog autoimunog encefalomijelitisa (EAE), nalaze se brojni upalni procesi kojima doprinose mnoge stanice imunološkog sustava. Međutim, rani događaji u mehanizmu razvoja multiple skleroze su još uvijek slabo opisani. Posebice uzvodni signali koji posreduju aktivaciju kao i raznovrsnost i patogenost ovih stanica, te njihova jedinstvena obilježja, a koja bi mogla poslužiti u svrhu razvoja ciljane terapije, su nedovoljno istražena. Naši publicirani, kao i preliminarni rezultati sugeriraju kako aktivacijski receptor NKG2D, kao urođeni senzor staničnog stresa, regulira efektorske funkcije te utječe na plastičnost pomoćničkih limfocita T tijekom upale, međutim mehanizam djelovanja ovog receptora se tek treba razjasniti. U ovom projektnom prijedlogu, mi kombiniramo moderne tehnologije genomike i sekvencioniranja na razini jedne stanice sa genetski modificiranim mišjim linijama te mišjim modelima bolesti kako bi rasvijetlili ulogu i doprinos NKG2D-ligand osi upalnoj bolesti središnjeg živčanog sustava posredovanoj limfocitima T. ]]></summary_hr><summary_en><![CDATA[Multiple sclerosis (MS) is an immune-mediated disease of the central nervous system (CNS) associated with inflammation, demyelination, oligodendrocyte loss and axonal injury. It is estimated that MS is the leading cause of nontraumatic neurological disability in 2.5 million young adults in North America and Europe who develop the disease between the ages of 20 and 50 years. Although the causes of MS are still unknown, next to a genetic predisposition, many different environmental factors such as vitamin D deficiency, obesity, smoking, and infection with the Epstein Barr virus (EBV) have been described to play a role in developing MS.Various immune cells have been described to contribute to the inflammatory processes that underlie MS and experimental autoimmune encephalomyelitis (EAE), a mouse model thereof. However, the very early events in this process during MS are still poorly understood. Moreover, the upstream signals that drive the activation as well as multifaceted nature and pathogenicity of these cells as well as the unique features thereof are still poorly defined. Our published and preliminary data suggest that activating receptor NKG2D, as an innate sensor of cellular stress, can modulate effector functions and impact plasticity of helper T cells during inflammation, however, mechanisms of action are still to be understood. In this project proposal we combine state-of the-art genomics- and sequencing-based technologies in combination with mouse genetic tools and in vivo mouse models of disease to elucidate the contribution of NKG2D/NKG2D-L axis to Th-driven CNS inflammation. ]]></summary_en></project><project>
<id>15323</id><title_hr><![CDATA[Organokatalitičke dearomatizacijske strategije inspirirane prirodnim spojevima]]></title_hr><title_en><![CDATA[Natural product-inspired organocatalytic dearomatization strategies]]></title_en><user_id>558</user_id><user_firstLast_name>Matija Gredičak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-5184</code><acronim><![CDATA[OCADA]]></acronim><duration>29.12.2023 - 28.12.2027</duration><status>U tijeku</status><financ_value>182.719,43 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>3233, 855382, 23628, 23654, 871130, 869894, 869949, 717, </team_members_id><team_members_names><![CDATA[Ana Mikleušević, Nikola Topolovcan, Shu-Li You, Chao Zheng, Robert Junior Kolman, Josip Rešetar, Lucija Žonja, Josipa Suć Sajko, ]]></team_members_names><keywords_hr><![CDATA[organska sinteza, dearomatizacija, asimetrična kataliza, organokataliza, policikličke strukture]]></keywords_hr><keywords_en><![CDATA[organic synthesis, dearomatization, asymmetric catalysis, organocatalysts, polycyclic molecules]]></keywords_en><summary_hr><![CDATA[Među 200 top lijekova prema maloprodaji u 2021., njih 71 sadrži policikličke jezgre. Čini se da je policiklička struktura idealno prikladna za razvoj lijekova s višestrukim mehanizmima djelovanja, budući da može poslužiti i kao osnovica za molekulu lijeka ili kao dio koji se može dodati radi poboljšanja njegovih farmakokinetičkih svojstava. Tradicionalne sintetske strategije za pripravu ovih struktura uključuju sintezu u više koraka i skupe početne spojeve, što ih čini dugotrajnim, neekonomičnim, nepraktičnim i ponekad zamornim. Stoga bi bilo od velike koristi kada bi neka jeftina i lako dostupna  kemijska sirovina - kao što su aromatski spojevi - mogla omogućiti izravan pristup ovim strukturama.Tradicionalne kemijske reakcije primjenjive na aromatske spojeve ograničene su njihovom posebnom stabilnošću - aromatičnosti - i obično uključuju supstitucijske reakcije, u kojima je aromatičnost molekule očuvana. Reakcije dearomatizacije, s druge strane, bježe od ograničenja inherentnih dvodimenzionalnih struktura aromatskih spojeva i mogu stvoriti sofisticiranu trodimenzionalnu molekularnu topologiju narušavanjem njihove aromatičnosti.U ovom projektu nastojimo se inspirirati poznatim lijekovima i bioaktivnim prirodnim spojevima, i razviti organokatalitičke asimetrične dearomatizacijske (OCADA) reakcije  aromatskih spojeva kako bismo proširili kemijski prostor s novim policikličkim strukturama kao mogućim naprednim građevnim blokovima.Glavni ciljevi ovog projekta su:(i) Razvoj novih OCADA reakcija aromatskih spojeva lako dostupnih iz obnovljivih izvora(ii) Provođenje mehaničkih studija za razjašnjenje uloge katalizatora i stereokemijske indukcije u razvijenim OCADA procesima(iii) Generiranje biblioteka policikličkih molekula sa strukturnom raznolikošću, te njihovo ispitivanje na antitumorsko i antibakterijsko djelovanje.]]></summary_hr><summary_en><![CDATA[Among the top 200 small molecule drugs by retail sales in 2021, 71 of them contain polycyclic skeletons. The polycyclic structure seems to be ideally suited for developing multiple mechanism drugs, as it can serve both as a scaffold for the drug molecule, or as a moiety that may be added to improve its pharmacokinetic properties. Traditional synthetic strategies towards these structures include multiple-step synthesis and expensive starting materials, which makes them time-consuming, uneconomical, impractical, and sometimes tedious. Hence, it would be highly beneficial if cheap and readily available bulk chemical feedstock - such as the aromatic compounds - could provide direct access to these structures. Traditional chemical reactions applicable for aromatic compounds are restricted by their special stability - aromaticity - and are usually limited to substitution reactions, where the aromaticity of the molecule is preserved. Dearomatization reactions, on the other hand, escape from the restrictions of the inherent two-dimensional structures of aromatic compounds and are able to forge sophisticated three-dimensional molecular topology by disrupting their aromaticity.In this proposal, we aim to take inspiration from known drugs and bioactive natural products, and develop organocatalytic asymmetric dearomatization (OCADA) reactions of aromatic compounds to expand chemical space with novel polycyclic molecular frameworks as possible advanced building blocks in research linked with drug discovery. The main aims of this project are:(i) Development of novel OCADA reactions of aromatic compounds readily available from sustainable sources(ii) Conduction of mechanistic studies in order to elucidate catalyst role and stereochemical induction in developed dearomatization processes(iii) Construction of molecular libraries of polycyclic scaffolds with structural novelty and diversity, and their screening for antitumor and antibacterial activities.]]></summary_en></project><project>
<id>15326</id><title_hr><![CDATA[Dobrobit i Mentalno Zdravlje Znanstvenika na Početku Karijere u Hrvatskoj-Longitudinalno Istraživanje]]></title_hr><title_en><![CDATA[Well-Being And Mental Health of Early Career Researchers in Croatia: A Longitudinal Study]]></title_en><user_id>6242</user_id><user_firstLast_name>Maja Tadić Vujčić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-3567</code><acronim><![CDATA[ECR-WELL]]></acronim><duration>18.12.2023 - 17.12.2027</duration><status>U tijeku</status><financ_value>115.209,34 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Psihologija, </scie_field_hr><scie_field_en>Psychology, </scie_field_en><institution_hr><![CDATA[Institut društvenih znanosti Ivo Pilar]]></institution_hr><institution_en><![CDATA[Institute of Social Sciences Ivo Pilar in Zagreb]]></institution_en><team_members_id>5575, 4720, 500, 21398, 12728, 6505, 20084, 866342, 866347, 866260, 870307, </team_members_id><team_members_names><![CDATA[Tomislav Hernaus, Filip Majetić, Marko Turk, Mirta Blažev, Ivana Maurović, Ivan Dević, Ana Havelka Meštrović, Maja Ribar Ribar, Anna Muro, Stefan Mol, Divna Blažev, ]]></team_members_names><keywords_hr><![CDATA[znanstvenici na početku karijere, dobrobit, mentalno zdravlje, longitudinalno istraživanje, radni uvjeti, teorija zahtjeva i resursa na poslu]]></keywords_hr><keywords_en><![CDATA[early career researcher, well-being, mental health, longitudinal research, work conditions, job demands-resources theory]]></keywords_en><summary_hr><![CDATA[Glavni temelj znanstvenog napretka je ljudski kapital: Motivirani istraživači ključni su za ispunjavanje značajnih zahtjeva visokokvalitetnih istraživanja, kao i za razvoj i prijenos znanja. Nažalost, nedavna istraživanja pokazuju alarmantne razine rizika za mentalno zdravlje, kao i sve manju razinu dobrobiti među istraživačima, posebno istraživačima na početku karijere (ECR) ?doktorandima i postdoktorandima. Nadovezujući se na teoriju zahtjeva i resursa na poslu, projekt odgovara na neke od postojećih nedostataka u znanju u ovom području ispitivanjem mehanizama važnih za dobrobit ECR-a, što se odražava u glavnim projektnim ciljevima: a) Korištenjem kvalitativne metodologije (fokus grupa i intervjua) dobiti dubinske uvide u radna iskustva i razumijevanja ECR-a o njihovoj dobrobiti i mentalnom zdravlju, kao i u perspektive mentora ECR-a o njihovim ulogama i radnim uvjetima koji omogućuju ECR-ovima da se osjećaju i funkcioniraju dobro; b) Ispitati odnose između osobnih (tj. osobne karakteristike) i kontekstualnih čimbenika (tj. zahtjeva i resursa posla) ECR-a i njihove dobrobiti i mentalnog zdravlja tijekom vremena, korištenjem longitudinalnog istraživanja u 6 mjerenja tijekom 3 godine putem on-line aplikacije; i c) Ispitati učinke job crafting intervencije na radne uvjete, dobrobit i mentalno zdravlje ECR-ova. Rezultati ECR-WELL projekta mogu podržati institucije u boljem razumijevanju i adekvatnom odgovoru na specifične potrebe ECR-a i njihove dobrobiti i mentalnog zdravlja. To je važno jer povećanje kvalitete radnih uvjeta i podrška ECR-ima može potaknuti njihovu dobrobit, mentalno zdravlje i, zauzvrat, njihovu znanstvenu produktivnost - jedan od strateških ciljeva razvoja znanosti. Štoviše, rezultati projekta mogu pružiti dublje uvide u ulogu dugoročnih longitudinalnih interakcija između individualnih i radnih čimbenika za dobrobit pojedinačnih zaposlenika i mentalno zdravlje općenito.]]></summary_hr><summary_en><![CDATA[The main building block of scientific progress is the human capital: Motivated researchers are crucial for meeting the increasing demands of high-quality research, as well as for the development and transfer of knowledge. Unfortunately, recent research shows alarming levels of mental health risks as well as declining well-being among researchers, particularly early career researchers (ECRs) ?doctoral candidates and postdoctoral researchers. Building upon the job demands-resources theory, the project aims to address some of the research gaps in this area by examining the mechanisms that can foster (vs. hinder) ECRs’ well-being, as reflected in the main project goals: a) To gain in-depth insights into the ECRs’ work experiences and understandings of their well-being and mental health, as well as into perspectives of ECRs’ mentors about their own roles, and work conditions that enable ECRs to thrive, using qualitative methodology (i.e. focus groups and interviews); b) To examine the interplay between ECRs’ individual (i.e., personal characteristics) and contextual factors (i.e., work conditions, job demands and resources), and their well-being and mental health over time, using a six-wave longitudinal survey throughout three years via a custom-made on-line application; and c) To examine the effects of job crafting intervention on ECRs’ working conditions, well-being, and mental health. In this way, the project can support institutions to understand and adequately respond to ECRs’ specific well-being and mental health needs. This is important because increasing the quality of the work conditions can foster ECRs’ well-being, mental health, and, in turn, their scientific productivity-one of the strategic goals of the development of science. Moreover, the project findings can provide deeper insights into the role of the long-term longitudinal interactions between individual and work factors for individual employees’ well-being and mental health in general.]]></summary_en></project><project>
<id>15327</id><title_hr><![CDATA[Prilagođavanje stanične stijenke probiotičkog kvasca za učinkovito izlaganje proteina slatkog okusa na površini stanica: niskokalorični zaslađivači nove generacije]]></title_hr><title_en><![CDATA[Modulating cell wall of probiotic yeast for efficient surface display of sweet proteins: next-generation low-calorie sweeteners ]]></title_en><user_id>4377</user_id><user_firstLast_name>Igor Stuparevic</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-6851</code><acronim><![CDATA[SWEET(y)EAST]]></acronim><duration>20.12.2023 - 19.12.2027</duration><status>U tijeku</status><financ_value>199.084,21 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Biotehnologija, </scie_field_hr><scie_field_en>Biotechnology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Food Technology and Biotechnology]]></institution_en><team_members_id>3258, 4450, 25073, 3326, 20179, 20884, 865158, 869698, </team_members_id><team_members_names><![CDATA[Renata Teparić, Bojan Žunar, Ana Novačić, Nino Sinčić, Marina Krpan, Mirta Boban, Mihaela Pravica, Romana Ivković, ]]></team_members_names><keywords_hr><![CDATA[Stanična stijenka kvasca, sekrecija proteina, izlaganje proteina na površini stanica, RNA egzosom, proteini slatkog okusa, Saccharomyces boulardii]]></keywords_hr><keywords_en><![CDATA[Yeast cell wall, protein secretion, surface display, RNA exosome, sweet-flavoured proteins, Saccharomyces boulardii]]></keywords_en><summary_hr><![CDATA[Nekolicina biljaka proizvodi proteine slatkog okusa, do 100.000 puta slađe od šećera. Za razliku od umjetnih sladila, npr. aspartama i sukraloze, ovi proteini ne potiču neželjen glikemijski odgovor i ne narušavaju crijevnu mikrobiotu. Nadalje, upotrebu nekih od ovih proteina kao zaslađivača već su odobrile Europska unija i Američka agencija za hranu i lijekove (FDA). Stoga su proteini slatkog okusa izvrsno pozicionirani da postanu niskokalorični zaslađivači nove generacije. Kako biljke sintetiziraju relativno malo ovih proteina, za njihovu industrijsku proizvodnju razvijeni su mikrobni bioprocesi. Međutim, izolacija velike količine slatkih proteina iz mikrobnih kultura trenutno je neisplativa. Stoga je primjena ovih proteina ograničena i njihov potencijal neiskorišten. U sklopu ovog projekta, mi ćemo adresirati ovaj problem prilagodbom stanične stijenke kvasca Saccharomyces cerevisiae i njemu srodnog probiotičkog kvasca Saccharomyces boulardii. Na ovaj način ćemo poboljšati potencijal ovih vrsta za sekreciju proteina slatkog okusa i izlaganje istih proteina na površini stanica. Pritom ćemo najprije pronaći nove RNA-vezujuće proteine koji putem RNA egzosoma precizno reguliraju metabolizam stanične stijenke kvasca i tako djeluju kao regulatorna čvorišta stanične stijenke. Stečene uvide ćemo iskoristiti za poticanje izlučivanja proteina slatkog okusa van stanice i njihovo izlaganje na površini stanice kvasca S. cerevisiae, vrste koja se općenito smatra sigurnom za ljudsko zdravlje. Konačno, stečene spoznaje preslikat ćemo i na probiotički kvasac S. boulardii, koji ćemo modificirati da proteine slatkog okusa veže na svoju vanjsku staničnu površinu. Ovim pristupom dizajnirat ćemo &#39;&#39;slatki&#39;&#39; probiotik i ujedno postaviti temelje za racionalno oblikovanje probiotičke stanične površine.]]></summary_hr><summary_en><![CDATA[Plant-evolved sweet-flavoured proteins are up to 100,000-fold sweeter than sugar and are approved for human consumption by FDA and European Union. Unlike artificial sweeteners, e.g., aspartame and sucralose, they do not adversely affect glycaemic response and gut microbiota. Thus, they are primed to become the next-generation low-calorie sweeteners. However, their large-scale isolation from microbial culture remains unprofitable. As such, their current application is limited, and their potential unrealised. In this project, we will modify the cell walls of the model yeast Saccharomyces cerevisiae and its probiotic relative Saccharomyces boulardii to enhance their potential for protein secretion and surface display. For this purpose, we will first identify novel RNA-binding proteins that fine-tune cell wall homeostasis and thus act as cell wall regulatory hubs. Next, we will use gained insights to boost protein secretion and surface display of sweet-flavoured proteins in the generally-regarded-as-safe yeast S. cerevisiae. Finally, we will translate our findings to the probiotic yeast S. boulardii, which we will modify to bind sweet-flavoured proteins to its outer cell surface. In this way, we will design “sweet” probiotics while opening new avenues for rational engineering of a probiotic cell surface.]]></summary_en></project><project>
<id>15332</id><title_hr><![CDATA[Fourierova analiza i primjene]]></title_hr><title_en><![CDATA[Fourier analysis and applications]]></title_en><user_id>740</user_id><user_firstLast_name>Vjekoslav Kovač</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-5116</code><acronim><![CDATA[FANAP]]></acronim><duration>31.12.2023 - 30.12.2027</duration><status>U tijeku</status><financ_value>149.293,25 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>866088, 864932, 866101, 22516, 865261, 22484, 865857, 21452, 522, 999, 867696, 867706, 871161, </team_members_id><team_members_names><![CDATA[Adrian Beker, Aleksandar Bulj, Nina Kamčev, Rudi Mrazović, Bruno Predojević, Jelena Rupčić, Ivana Slamić, Mario Stipčić, Hrvoje Šikić, Kristina Ana Škreb, Tonći Crmarić, Tadej Petar Tukara, shobu shiraki, ]]></team_members_names><keywords_hr><![CDATA[Fourierova transformacija, množitelj, teorija mjere, valić, aditivna kombinatorika, Ramseyeva teorija]]></keywords_hr><keywords_en><![CDATA[Fourier transform, multiplier, measure theory, wavelet, additive combinatorics, Ramsey theory]]></keywords_en><summary_hr><![CDATA[Projekt će prvenstveno proučavati aktualne teme iz Fourierove analize: točkovna svojstva i restrikciju Fourierove transformacije, nelinearne Fourierove modele te ocjene za Fourierove množitelje. Uz to će analitičkim tehnikama rješavati probleme u drugim granama matematike: geometrijskoj teoriji mjere, teoriji valića i drugih funkcijskih sustava, aritmetičkoj kombinatorici i Ramseyevoj teoriji. Predložena istraživačka grupa objedinjuje ugledne istraživače s hrvatskih znanstvenih institucija koje su se dosad, ili bavili temama iz Fourierove analize, ili im je Fourierova analiza činila značajan udio u korištenim tehnikama. Uz njih istraživačka grupa će uključiti i nekoliko mlađih istraživača. Najveći dio istraživanja bit će usmjeren prema potpunim ili djelomičnim rješenjima poznatih otvorenih problema.]]></summary_hr><summary_en><![CDATA[The project will primarily study current topics from Fourier analysis: pointwise properties and restriction of the Fourier transform, nonlinear Fourier models, and estimates for Fourier multipliers. In addition, analytical techniques will be used to solve problems in other branches of mathematics: geometric measure theory, the theory of wavelets and other function systems, arithmetic combinatorics, and Ramsey theory. The proposed research group brings together distinguished researchers from Croatian scientific institutions who have, either worked in Fourier analysis, or Fourier analysis has been a significant part of the techniques that they used. In addition to them, the research group will also include several younger researchers. Most of the research will be directed towards complete or partial solutions of known open problems.]]></summary_en></project><project>
<id>15333</id><title_hr><![CDATA[Fotoinducirani  procesi u molekulama: Susret teorije i eksperimenta]]></title_hr><title_en><![CDATA[Photoinduced Processes in Molecules: Theory Meets Experiment]]></title_en><user_id>2848</user_id><user_firstLast_name>Nađa Došlić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-4658</code><acronim><![CDATA[PhInMol]]></acronim><duration>29.12.2023 - 28.12.2027</duration><status>U tijeku</status><financ_value>115.707,75 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>26197, 3692, 521, 29625, 2736, 25276, 870701, 869936, </team_members_id><team_members_names><![CDATA[Mihael Eraković, Marko Tomislav Cvitaš, Ivan Ljubić, Jovan Odavić, Jurica Novak, Tomislav Piteša, Manuel Martinović, Haseena Sheik, ]]></team_members_names><keywords_hr><![CDATA[Vremenski ovisna Schroadingerova jednadžba, Neadijabatska molekulska dinamika,  vremenski različena spektroskopija, fotofizika, fotokemija]]></keywords_hr><keywords_en><![CDATA[Time resolved Schrödinger equation, nonadiabatic molecular dynamics, time resolved spectroscopy, photochemistry, photophysics]]></keywords_en><summary_hr><![CDATA[Razjašnjenje elektroničkih i strukturnih transformacija kroz koje kemijski sustav prolazi nakon interakcije sa zračenjem od temeljne je važnosti za unaprijeđenje novih funkcionalnih molekula i materijala. Potpuno razumijevanje ovih procesa moguće je samo sinergističkom kombinacijom teorijskih i eksperimentalnih istraživanja.Visokointenzivni i ultrakratki  fotonski pulsevi  lasera sa slobodnim elektronimaa (FEL) revolucioniralo je područje ultrabrze spektroskopije.  Novi izvori svjetlosti generiraju podatke neviđene kvalitete, ali kako bi se u potpunosti iskoristio njihov potencijal, eksperimentalne podatke je potrebno točno interpretirati. To zahtjeva naprednu teoriju i sofisticirane izračune.U svrhu boljeg razumijevanja fotoinduciranih procesa u molekulama, predloženi projekt integrira neadijabatsku molekularnu dinamiku, teoretsku fotoelektronsku spektroskopiju i izazovne aplikacije. Specifični ciljevi projekta su (i) razviti i implementirati napredne mješovite kvantno-klasične i semiklasične metode za neadijabatsku dinamiku, (ii) proširiti i poboljšati zagrebački kod preskakanja ploha za simulaciju i analizu neadijabatske molekularne dinamike; (ii) implementirati učinkovite protokole za računavanje vremenski razlučenih signala fotoelektronske spektroskopije, uključujući fotoelektronsku spektroskopiju valentnih i sržnih elektrona, cirkularni dikroizam fotoelektrona i koincidencijsku spektroskopiju fotoelektrona i  fotoiona; (iv) primijeniti ove metode za proučavanje zahtjevnih  molekularnih sustava od atmosferskog, astrokemijskog i biološkog interesa. Rezultati naših simulacija će pomću i interpretaciji eksperimenata koji će se izvoditi na FELu FERMI i europskim XFELu.]]></summary_hr><summary_en><![CDATA[The elucidation of the electronic and structural transformations that a chemical system undergoes after light-irradiation is of fundamental importance for refining and optimizing new functional molecules and materials. A proper understanding of these processes is possible only through a synergistic combination of theoretical and experimental research. The field of ultrafast spectroscopy has been revolutionized by the ability to produce ultrashort, high-brightness photon pulses with free-electron lasers (FEL).  New light sources generate data of unprecedented quality, but to fully exploit their potential, experimental data need to be accurately interpreted.  This in turn requires advanced theory and sophisticated calculations.To achieve a better understanding of photoinduced processes in molecules, the proposed project integrates nonadiabatic molecular dynamics, theoretical photoelectron spectroscopy and cutting-edge applications.  The specific  goals of the project are (i) to develop and implement advances mixed quantum-classical and semiclassical methods for nonadiabatic dynamics, (ii) to extend and improve the Zagreb surface hopping code for nonadiabatic molecular dynamics simulations and analysis ; (ii) to implement efficient protocols for the computation of time-resolved photoelectron spectroscopy signals, including valence and core-level photoelectron spectroscopy, photoelectron circular dichroism and photoelectron photoion coincidence spectroscopy; and (iv) to apply these methods to study challenging molecular systems of atmospheric, astrochemical and biological interest.   The results of our simulations will be used to interpret  state-of-the-art experiments, which will be performed at the FERMI and European XFEL.]]></summary_en></project><project>
<id>15339</id><title_hr><![CDATA[Izvori za hrvatsku povijest – istraživanje, kritičko izdavanje i analiza]]></title_hr><title_en><![CDATA[Sources for Croatian History – Research, critical  editing and analysis]]></title_en><user_id>3017</user_id><user_firstLast_name>Damir Karbić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-5130</code><acronim><![CDATA[IZVORI22]]></acronim><duration>18.12.2023 - 17.12.2027</duration><status>U tijeku</status><financ_value>111.840,00 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Povijest, </scie_field_hr><scie_field_en>History, </scie_field_en><institution_hr><![CDATA[Hrvatska akademija znanosti i umjetnosti]]></institution_hr><institution_en><![CDATA[Croatian Academy of Sciences and Arts]]></institution_en><team_members_id>3006, 2525, 4085, 1535, 1534, 4071, 3036, 6488, 5727, 382, 418, 5605, 4169, 19013, 866175, 13552, 5315, 866119, </team_members_id><team_members_names><![CDATA[Zoran Ladić, Tihana Luetić, Sabine Florence Fabijanec, Branka Grbavac, Iva Kurelac, Suzana Miljan, Goran Budeč, Mirko Sardelić, Zrinka Novak, Lovorka Čoralić, Filip Novosel, Ivan Jurković, Robert Kurelic, Ana Biočić, Marino Martinčević, Krisztina Arany, Eva Batorine Halasz, Fabian Kuemmeler, ]]></team_members_names><keywords_hr><![CDATA[povijesni izvori, pomoćne povijesne znanosti, društvena povijest, gospodarska povijest, kulturna povijest]]></keywords_hr><keywords_en><![CDATA[historical sources, auxiliary disciplines of history, social history, economic history, cultural history]]></keywords_en><summary_hr><![CDATA[Projekt Izvori za hrvatsku povijest – istraživanje, kritičko izdavanje i analiza usredotočen je na izvore i njihovu obradu kao temeljni element i preduvjet svih ostalih suvremenih povijesnih istraživanja. Krajnji cilj projekta je, kroz sedam manjih projektnih zadataka, razmotriti različite aspekte povijesnih izvora na tematskoj osnovici te kao cjelina znatno povećati naše poznavanje problematike koju se istražuje. Također je cilj ostvariti istraživanjima preduvjete za pripremu kritičkih izdanja te izraditi nekoliko zbirki izvora čime će se i drugim istraživačima omogućiti lakši pristup navedenoj građi.Projektni zadaci pokrivaju kronološki raspon od srednjeg vijeka do kraja 19. i početka 20. st., s težištem na starijim razdobljima. U tematskom smislu pokriva se široki raspon problema od izvora za proučavanje društvene povijesti (povijesti elita, urbanih i ruralnih sredina), povijesti gospodarstva i prometa do intelektualne i kulturne povijesti. U geografskom smislu projekt se bavi čitavim hrvatskim etničkim prostorom, iako su pojedini zadaci fokusirani na pojedine mikrocjeline (poput Raba ili Korčule). Također se hrvatski prostor promatra u njegovim širim okvirima (u prvom redu onim Srednje Europe, Mediterana i Jugoistočne Europe), čemu doprinosi i prisutnost stranih istraživača iz Austrije i Mađarske u projektnom timu.Po metodološkom pristupu projekt je čvrsto fokusiran na terenska (arhivska) istraživanja s ciljem nadopunjavanja dosadašnjih spoznaja, ali nije nimalo zanemaren ni aspekt analitičkog pristupa. Rezultati projekta također će biti komunicirani znanstvenoj javnosti putem organizacije nekoliko znanstvenih skupova (jedna radionica, jedan okrugli stol te međunarodni bilateralni znanstveni skup), kao i sudjelovanjima sudionika na projektu na brojnim znanstvenim skupovima u Hrvatskoj i inozemstvu. Takav pristup vidljiv je i iz predviđenih troškova projekta koji se u osnovi koncentriraju na terenska istraživanja i diseminacijske aktivnosti.]]></summary_hr><summary_en><![CDATA[Project Sources for Croatian History - Research, Critical Editing and Analysis is centred on sources and their discussion as a basic element and precondition of all other historical research. Final objective of the project is, by the work on seven smaller project tasks, to discuss different aspects of historical sources on the thematic basis and, as a whole, to increase our knowledge of problematics under research. An objective is also to achieve preconditions for preparation of critical editions and to produce several collections of sources, which will also enable other researchers easier access to the mentioned source materials.Project tasks cover chronological span from the Middle Ages to the end of the 19th and the beginning of the 20th century, with an emphasis on earlier periods. In the thematic sense, it covers wide range of problems from sources for discussion of social history, history of economy and traffic to intellectuial and cultural history. In geographic sense, the project deals with whole Croatian area, even though particular tasks are focused on particula microunits (Rab and Korčula). Also, Croatian space is viewed in his wider settings (Central Europe, Mediterranean and South East Europe), to which aim also contributes the presence of foreign researchers from Austria and Hungary within the project team.According to its methodological approach, the project is firmly focused on archival research with the aim of increasing current knowledge, but the aspect of analytical approach is not neglected at all either. Results of the project will be also communicated to the scholarly public by organisation of several scholarly conferences (workshop, round table, international bilateral scholarly conference), as well as by participation of the team leader and members in a number of scholarly conferences in Croatia and abroad. Such approach is visible also from the financial plan of project which concentrates costs on field research and dissemination activities.]]></summary_en></project><project>
<id>15340</id><title_hr><![CDATA[Okolišni aspekti SARS-CoV-2 antivirotika]]></title_hr><title_en><![CDATA[Environmental Aspects of SARS-CoV-2 Antiviral Substances]]></title_en><user_id>4661</user_id><user_firstLast_name>Šime Ukić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-2822</code><acronim><![CDATA[EnA-SARS]]></acronim><duration>15.12.2023 - 14.12.2027</duration><status>U tijeku</status><financ_value>166.700,00 eur</financ_value><scie_area_hr>Tehničke znanosti, Prirodne znanosti, </scie_area_hr><scie_area_en>Technological sciences, Natural sciences, </scie_area_en><scie_field_hr>Kemijsko inženjerstvo, Kemija, Interdisciplinarne tehničke znanosti, </scie_field_hr><scie_field_en>Chemical engineering, Chemistry, Interdisciplinary technological sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet kemijskog inženjerstva i tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Chemical Engineering and Technology]]></institution_en><team_members_id>1298, 26667, 25625, 2711, 27210, 13134, 866143, 20856, 4429, 866197, 1301, 864972, 866513, 12655, 869820, 872900, </team_members_id><team_members_names><![CDATA[Tomislav Bolanča, Želimira Cvetković, Dajana Kučić Grgić, Marinko Markić, Martina Miloloža, Lidija Furač, Pavle Jelicic, Matija Cvetnić, Magdalena Ujević Bošnjak, Gabriela Kalčikova, Ana Mornar Turk, Viktorija Prevarić, June Liu, Marin Ganjto, Dora Lastovčić, Luka Večenaj, ]]></team_members_names><keywords_hr><![CDATA[ onečišćene vode, SARS-CoV-2, antivirotici, okolišni aspekti, biodegradacija, napredni oksidacijski procesi]]></keywords_hr><keywords_en><![CDATA[polluted waters, SARS-CoV-2, antivirals, environmental aspects, biodegradation, advanced oxidation processes]]></keywords_en><summary_hr><![CDATA[Znanstvenici diljem svijeta trenutno su fokusirani na ispitivanje utjecaja SARS-CoV-2 virusa na ljude te pronalaženje načina za sprječavanje ili barem ublažavanje simptoma COVID-19 bolesti. Međutim postoje i neki drugi aspekti vezani uz COVID-19 koje također treba detaljno istražiti. Među njima bismo istaknuli okolišni utjecaj antivirotika koji se koriste protiv SARS-CoV-2 virusa. Kao i kod većine lijekova, tako i kod antivirotika, ljudsko tijelo metabolizira 60-70 % aktivne supstance. Zaostali metaboliti i nemetabolizirana tvar izlučuju se iz tijela te završavaju u otpadnim vodama. Drugi mogući izvori antivirotika u otpadnim vodama uključuju bolnički otpad, otpadne vode farmaceutske industrije te odlaganje neiskorištenih lijekova ili lijekova s isteklim rokom valjanosti. Poznato je da konvencionalna postrojenja za pročišćavanje otpadnih voda većinu farmaceutika ne uklanjaju dovoljno učinkovito. Stoga ne čudi da su brojne studije potvrdile prisutnost antivirotika u vodenom okolišu, što predstavlja ozbiljan rizik za okoliš. Sudbina i ponašanje SARS-CoV-2 antiviralnih supstanci (SAS) u vodenom okolišu relativno su nepoznati. Ujedno, mali je i broj dosad objavljenih istraživanja o uklanjanju SAS-a iz okoliša. Stoga je glavna nakana EnA-SARS projekta rasvijetliti sudbinu i ponašanje SAS-a u okolišu što je ključno za procjenu stvarnog rizika po okoliš. Pri tome će provesti procjena ekotoksikološkog rizika uključujući i moguće sinergističko djelovanje SAS-a. Nadalje, ispitat će se različiti postupci remedijacije voda onečišćenim SAS-ovima: napredni oksidacijski procesi, bioremedijacija te kombinacija navedenih postupaka. Najučinkovitiji postupak odabrat će se primjenom metodologije odlučivanja na temelju više kriterija nastojeći obuhvatiti najbolju učinkovitost uklanjanja i najveću financijsku isplativost postupka.]]></summary_hr><summary_en><![CDATA[Scientists around the world are currently focused on the impact of the SARS-CoV-2 virus on human health and on finding ways to prevent COVID -19 infection or at least alleviate the symptoms of infection. However, other impacts associated with COVID-19 also deserve in-depth study. We would like to highlight here the environmental impact of antivirals used to combat SARS-CoV-2. For most drugs, including antivirals, the human body metabolizes only 60-70% of the active ingredient. The residual metabolites and unmetabolized substances are excreted from the body and discharged into wastewater. Other potential sources of antivirals include hospital waste, wastewater from the pharmaceutical industry, and disposal of unused or outdated drugs. Unfortunately, it is well known that conventional wastewater treatment plants are not capable of effectively removing most of these substances. Therefore, many studies have confirmed the presence of antiviral substances in the aquatic environment, which pose a serious environmental risk. The fate and behavior of SARS-CoV-2 antiviral substances (SAS) in the aquatic environment are still relatively unknown. At the same time, the number of studies published to date on the removal of SAS from the environment is small. Therefore, the main objective of the EnA-SARS project is to investigate the fate and behavior of SAS in the environment, which is crucial for assessing the actual environmental risk. Therefore, an ecotoxicological risk assessment, including the investigation of possible synergistic effects, will be performed within the project. In addition, various processes for remediation of SAS-contaminated water will be investigated, including advanced oxidation processes, bioremediation, and a combination of the above. The most effective process will be selected by applying a multi-criteria decision-making considering the best removal efficiency and the highest cost-effectiveness of the process.]]></summary_en></project><project>
<id>15346</id><title_hr><![CDATA[Mapiranje prostorne varijabilnosti likvefakcijskog potencijala ispod nasipa za obranu od poplava i modeliranje optimalnih mitigacijskih tehnika]]></title_hr><title_en><![CDATA[Mapping of the spatial variability of liquefaction potential below the levees and modelling of optimal mitigation techniques]]></title_en><user_id>2652</user_id><user_firstLast_name>Mario Bačić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-7608</code><acronim><![CDATA[LeveeLiq]]></acronim><duration>30.12.2023 - 29.12.2027</duration><status>U tijeku</status><financ_value>145.230,11 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Građevinarstvo, </scie_field_hr><scie_field_en>Civil engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Građevinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Civil Engineering]]></institution_en><team_members_id>2571, 2660, 2887, 25683, 5920, 871151, </team_members_id><team_members_names><![CDATA[Meho Saša Kovačević, Lovorka Librić, Marijan Car, Kenneth Gavin, Kosta Urumović, Nicola Rossi, ]]></team_members_names><keywords_hr><![CDATA[likvefakcija, nasip za obranu od poplava, ocjena likvefakcijskog potencijala, fizikalni modeli, mitigacijske mjere]]></keywords_hr><keywords_en><![CDATA[liqefaction, levee, liquefaction potential assessment, physical models, mitigation measures]]></keywords_en><summary_hr><![CDATA[Likvefakcija, kao fenomen uslijed kojeg se tijekom potresa tlo pretvara u gustu tekućinu, čime gubi svoju čvrstoću i krutost, je odgovorna za brojne štete na infrastrukturi. Ilustrativan primjer je potres koji je 2020. godine zadesio sisačko-moslavačku županiju, gdje je došlo do prekomjernih deformacija i sloma niza nasipa za obranu od poplava, što je izazvalo opravdanu zabrinutost upravitelja infrastrukturom radi mogućih kaskadnih poplava. U cilju mapiranja likvefakcijskog potencijala (LP) tla, prethodni istraživački napori su se ili oslanjali na diskretna ispitivanja tla, zanemarujući njegovu inherentnu prostornu varijabilnost, ili su eksploatirala geološke i hidrogeološke informacije u krupnom mjerilu što onemogućava donošenje odluka na razini pojedinog nasipa. Inovativna metodologija za pouzdano mapiranje prostorne varijabilnosti LP-a, razvijena u sklopu LeveeLiq projekta, se oslanja na in-situ podatke mjerene s više senzora. Ovi podaci će se koristiti za razvoj algoritma za evaluaciju likvefakcijske prostorne varijabilnosti, a koji će se integrirati u digitalno sučelje. Nadalje, na temelju podatka o varijabilnosti LP-a, u projektu će se optimizirati mitigacijske mjere, za što će se koristiti složene 3D numeričke simulacije kalibrirane na rezultatima monitoringa fizikalnih laboratorijskih modela. Metodologija će se validirati na odabranom pilot području, uz izradu priručnika sa smjernicama za implementaciju iste u postojeći okvir upravljanja sustavima za obranu od poplava. Osim upravitelja infrastrukturom, od mjerljivih rezultata, koji među ostalim uključuju i 8 radova u časopisima i na konferencijama te 11 znanstveno–tehničkih izvještaja, korist će imati znanstvena zajednica kroz unaprjeđeni protokol za mapiranje prostorne distribucije LP-a ispod linijskih građevina, kao i šira javnost kroz povećanje sigurnosti sustava zaštite od poplava, čime se u slučaju potresa minimalizira vjerojatnost pojave poplave kao kaskadnog hazarda.]]></summary_hr><summary_en><![CDATA[Liquefaction, as a phenomenon which turns a soil into a dense liquid during an earthquake, losing its strength and stiffness, is responsible for numerous damages to infrastructure. An illustrative example is the earthquake that struck the Sisacko-Moslavacka County in 2020, where excessive deformations and failures of series of levees occurred, causing a justified concern of infrastructure managers about the possible cascading floods. In order to map soil liquefaction potential (LP), previous research efforts either relied on discrete soil investigations, ignoring its inherent spatial variability, or exploited geological and hydrogeological information on a large scale, which makes it impossible to implement decision-making on the asset (levee) - level. The innovative methodology for reliable mapping of LP spatial variability, developed within the LeveeLiq project, relies on in-situ data measured by multiple sensors. This data will be used to develop an algorithm for the evaluation of liquefaction spatial variability, which will be integrated into a digital interface. Furthermore, based on information on LP variability, mitigation measures will be optimized in the project through utilization of complex 3D numerical simulations calibrated on the results of physical laboratory models&#39; monitoring. The methodology will be validated in the selected pilot area, along with the development of a handbook with guidelines for its implementation in the existing flood defense management framework. In addition to infrastructure managers, the scientific community will benefit from the project&#39;s outputs, including 8 journal and conference papers along with 11 scientific-technical reports, through an improved protocol for mapping the spatial distribution of LP under linear structures. The general public will also benefit through increased safety of the flood protection system, which minimizes the probability of flooding as a cascading hazard in the event of an earthquake.]]></summary_en></project><project>
<id>15349</id><title_hr><![CDATA[Metom usmjerena sinteza inhibitora kolinesteraza podržana strojnim učenjem]]></title_hr><title_en><![CDATA[Target-guided synthesis of cholinesterase inhibitors supported by machine learning]]></title_en><user_id>346</user_id><user_firstLast_name>Ines Primožič</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-9525</code><acronim><![CDATA[TargetCh]]></acronim><duration>30.12.2023 - 29.12.2027</duration><status>U tijeku</status><financ_value>148.649,55 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>5462, 991, 5956, 861709, 19438, 28972, 28772, 3752, 19889, 867695, 869871, </team_members_id><team_members_names><![CDATA[Tomica Hrenar, Anita Bosak, Renata  Odžak, Ricardo Mata, Alma Ramic, Ana Matošević, Ana Mikelić, Marina Kranjac, Karlo Sović, Toni Divjak, Matea Laučan, ]]></team_members_names><keywords_hr><![CDATA[organska sinteza, metom usmjerena sinteza, inhibitori kolinesteraza, kvantno-kemijski proračuni, strojno učenje, multivarijatna linearna regresija]]></keywords_hr><keywords_en><![CDATA[organic synthesis, target-guided synthesis, cholinesterase inhibitors, quantum chemical calculations, machine learning, multivariate linear regression]]></keywords_en><summary_hr><![CDATA[U ovom projektu metom usmjerena sinteza, karakterizacija spojeva i biološka evaluacija novih tipova diamidnih spojeva kombinirat će se s naprednim kvantnokemijskim metodama i strojnim učenjem. Bioaktivni kemijski skeleti bit će dizajnirani i sintetizirani korištenjem Ugijeve reakcije i metom usmjerene sinteze kako bi se dobili inhibitori butirilkolinesteraze (BChE), koji se potencijalno mogu koristiti kao dio liječenja Alzheimerove bolesti. Pripravit će se različiti kiralni spojevi i procijeniti stereoselektivnost interakcija. Odredit će se konstante vezanja spojeva prema BChE, kao i selektivnost inhibicije prema BChE u usporedbi s acetilkolinesterazom (AChE). Posebno će biti analiziran utjecaj promjene supstituenata na jačinu inhibicije. Za procjenu mogućih povoljnih sinergijskih učinaka pripremit će se i ispitati različite kombinacije najaktivnijih sintetiziranih spojeva. Kvantno-kemijski proračuni koristit će se za određivanje standardnih Gibbsovih energija vezanja za sve sintetizirane spojeve te za otkrivanje najvažnijih interakcija unutar katalitičkog aktivnog mjesta ili perifernog anionskog mjesta u enzimima. Poveznica između izmjerenih afiniteta vezanja i teorijskih podataka bit će uspostavljena pomoću multivarijantne linearne regresije putem strojnog učenja. Eksperimentalno dobiveni podaci o inhibiciji bit će regresirani na teoretski izračunate površine potencijalne energije uzorkovane iz ab initio molekularne dinamike. Najbolji mogući regresijski model za inhibicijske/teorijske podatke bit će odabran na temelju različitih statističkih parametara te iskorišten kao snažan alat za predviđanje inhibicije AChE i BChE (uključujući i selektivnost) za nove slične spojeve i to samo na temelju in silico eksperimenata. To će omogućiti usavršavanje i daljnju optimizaciju najaktivnijih spojeva u svrhu pronalaženja boljih i visoko selektivnih inhibitora kolinesteraza s potencijalnom upotrebom u biotehnologiji, farmaceutskoj industriji i medicini.]]></summary_hr><summary_en><![CDATA[In this project target-guided synthesis, compound characterization and biological evaluation of novel types of diamide compounds will be combined with advanced quantum chemical methods and machine learning. Bioactive chemical scaffolds will be designed and synthesized using Ugi reaction and target-guided synthesis to obtain inhibitors of butyrylcholinesterase (BChE), which potentially can be used as a part of the treatment of Alzheimer’s disease. Chiral compounds will be prepared and the stereoselectivity of interactions evaluated. Binding constants of compounds toward BChE will be determined as well as inhibition selectivity to BChE compared to acetylcholinesterase (AChE). The impact of the change of substituents on the inhibition potency will be analyzed separately. To evaluate possible beneficial synergistic effects, various combinations of the most active synthesized compounds will be prepared and tested. Quantum chemical calculations will be used to determine the standards Gibbs energies of binding for all synthesized compounds and to reveal the main interactions within the catalytic active site or peripheral anion site in enzymes. The connection between measured binding affinities and theoretical data will be established using machine learning multivariate linear regression. Experimentally obtained inhibition data will be regressed on theoretically calculated potential energy surfaces sampled from the ab initio molecular dynamics. The best possible inhibition/theoretical data regression model will be selected based on various statistical parameters and used as a powerful tool to predict AChE and BChE inhibition (including selectivity) inhibition for new similar compounds based only on the in silico experiments. This will enable the refinement and further optimization of the lead compounds toward finding more powerful and highly selective cholinesterase inhibitors with potential use in biotechnology, pharmaceutical industry and medicine.]]></summary_en></project><project>
<id>15352</id><title_hr><![CDATA[Pomorska primjena plutajućih solarnih fotonaponskih sustava]]></title_hr><title_en><![CDATA[Marine Applications of Floating Solar Photovoltaic Systems]]></title_en><user_id>5584</user_id><user_firstLast_name>Ivan Ćatipović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-4408</code><acronim><![CDATA[MARSOL]]></acronim><duration>31.12.2023 - 30.12.2027</duration><status>U tijeku</status><financ_value>198.813,19 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Brodogradnja, Elektrotehnika, Interdisciplinarne tehničke znanosti, </scie_field_hr><scie_field_en>Naval architecture, Electrical engineering, Interdisciplinary technological sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>25884, 22651, 6827, 26962, 866148, 6070, 864826, </team_members_id><team_members_names><![CDATA[Neven Alujević, Inno Gatin, Mario Matijević, Antonio Mukilić, Darko Smoljan Smoljan, Krešimir Trontl, Tomislav Prosinečki, ]]></team_members_names><keywords_hr><![CDATA[plutajući fotonaponski sustavi, pomorski okoliš, opterećenja i gibanja valova, opterećenja morskih struja i vjetra, sidrenje, energetski prinos]]></keywords_hr><keywords_en><![CDATA[floating photovoltaics, marine environment, wave loads and motions, sea current loads and wind loads, mooring, energy yield]]></keywords_en><summary_hr><![CDATA[Obnovljivi izvori energije su obećavajuća alternativa za fosilna goriva. Plutajući fotonaponski (PFN) sustavi su dio ovih novih rješenja jer se njihova ukupna isporučena energija godišnje udvostruči. Mnogi PFN sustavi su postavljeni na vodenim područjima kao što su jezera i akumulacije. Međutim, primjena PFN sustava u pomorskom okolišu je ograničena zbog surovih uvjeta ovakvog okoliša.Det Norske Veritas je 2021. prvi na svijetu objavio preporučenu praksu (eng: Recommended Practice, RP) za PFN projekte za pomorske lokacije koje su blizu obale te su donekle zaštićene. Pregledom recentne literature te usporedbom s zahtjevima ove preporuče prakse utvrđeno je da postoje mnoge nepoznanice vezane za instalacije PFN sustava na moru. Rasvjetljavanje ovih nepoznanica upravo su ciljevi projekta MARSOL.Ukupna opterećenja na PFN sustave na moru uzrokuju valovi, morska struja i vjetar. Valna opterećenja i gibanja proučavat će se eksperimentalno u bazenu s umanjenim modelom usidrenog PFN sustava. Numerička analiza provest će se kombinacijom rješavača (eng solver) temeljenog na potencijalnom strujanju i RANS-a (eng: Reynolds Averaged Navier-Stokes). Opterećenja morskih struja također će se proučavati eksperimentalno i uz pomoć RANS-a. Opterećenje vjetra i njegovu ovisnost o turbulenciji istražit će se numeričkim metodama iz postojećih preporuka.Sustav za sidrenje je kritičan za PFN sustave na moru jer igra sastavnu ulogu u strukturnom integritetu cijelog sustava. Izvest će se model sidrenja koji će moći razmatrati veliki broj plutajućih tijela.Specifičnost PFN sustava na moru, kod proizvodnje električne energije, je pojava gubitaka neusklađenosti koji su izazvani valnim gibanjima. Uzimajući u obzir ove gubitaka te električnu mrežu fotonaponskih (FN) modula, razvit će se numerički model ukupnog prinosa energije.Zaključno, projekt MARSOL poboljšat će postojeću metodologiju ili razviti novu za potrebe projektiranja sigurnih PFN sustava na moru.]]></summary_hr><summary_en><![CDATA[Renewable energy sources promise a sustainable alternative to fossil fuels. Floating photovoltaics (FPVs) supports the alternative as their total energy production doubles yearly. Many FPVs operate in water areas such as lakes, ponds and reservoirs. However, the deployment of FPVs in the marine environment is limited due to the harsh environmental conditions.In 2021, Det Norske Veritas released the world&#39;s first Recommended Practice (RP) for FPV projects at maritime locations close to the coast that are somewhat protected. Based on discrepancies between RP and the current state of the art, the knowledge gaps are identified and set as the research objectives of MARSOL project.The total environmental loads on FPVs at sea consist of the wave, sea current and wind loads. Each load and response will be studied in MARSOL project. Wave loads and motions will be experimentally investigated in a towing tank with a scaled model with an associated mooring system. Numerically, combining a potential flow solver and a Reynolds Averaged Navier-Stokes (RANS) solver. The sea current loads will also be observed by a RANS solver and experiments in a towing tank. The wind loads and their relation to the airflow turbulence will be studied using the numerical approaches from existing recommendations.The mooring system is critical for FPVs at sea since it plays an integral part in the structural integrity of the whole system. A coupled model will be built up capable of considering a large number of floating bodies that experiments in a towing tank will validate.When estimating energy yield, a particularity of FPVs instaled at sea is in the mismatch losses caused by the wave-induced motions. The energy yield numerical model will be developed considering these losses and the string configuration of photovoltaic (PV) modules,.In conclusion, MARSOL project will improve the existing methodology or develop new ones necessary for the safe design of FPVs deployed in the marine environment.]]></summary_en></project><project>
<id>15353</id><title_hr><![CDATA[Numerička procjena učinkovitosti 4D ispisanih karotidnih stentova]]></title_hr><title_en><![CDATA[Numerical evaluation of medical performance of 4D printed carotid stents]]></title_en><user_id>1010</user_id><user_firstLast_name>Igor Karšaj</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-1497</code><acronim><![CDATA[FORECAST]]></acronim><duration>01.02.2024 - 31.01.2028</duration><status>U tijeku</status><financ_value>132.399,73 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, Interdisciplinarne tehničke znanosti, </scie_field_hr><scie_field_en>Mechnical engineering, Interdisciplinary technological sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>19003, 24057, 7650, 866134, 17761, 866117, 866229, 869324, 869840, </team_members_id><team_members_names><![CDATA[Nino Horvat, Marija Smoljkić, David Ozretić, Ana Lisac, Marija Galić, Antun Jakob Marić, Luka Biondic, Luka Labar, Nino Pintarić, ]]></team_members_names><keywords_hr><![CDATA[karotidni stent, toplinska prisjetljivost materijala, 3D ispis, smola, numerički model, eksperimentalni testovi]]></keywords_hr><keywords_en><![CDATA[carotid stent, thermal shape, 3D print, resin, numerical model, experimental test]]></keywords_en><summary_hr><![CDATA[Jedan od glavnih nedostataka stentova koji se trenutno koriste je oštećenje stijenke arterija prilikom postupka proširenja stenta balonom. To dovodi do pojave restenoze nakon ugradnje stenta. Novi trend na području razvoja stentova na kojem se provode opsežna istraživanja su polimerni biorazgradivi stentovi, koji bi privremeno proširili lumen žile čekajući zacjeljivanje stijenke arterije, a zatim bi se s vremenom razgradili. Međutim, kako su mehanička svojstva polimera u usporedbi s metalima puno lošija, polimerni stentovi su puno deblji što dodatno uzrokuje nove probleme i rizike.Samo-ekspandirajući 4D tiskani stentovi imaju potencijal za smanjenje ovih nedostataka. Stoga predlažemo eksperimentalnu procjenu medicinske učinkovitosti takvih uređaja ugradnjom 4D tiskanog stenta u silikonsku arteriju sa stenozom. Budući da mehaničko ponašanje polimera nije identično onom arterije, također je neophodna i njena numerička procjena. Potrebno je razviti i konstitutivni model 4D tiskanog materijala. U tu svrhu će se provesti opsežna mehanička ispitivanja i odrediti materijalni parametri odabranog konstitutivnog modela. Postupak postavljanja stenta numerički će se modelirati uzimajući u obzir rast i strukturne promjene arterije kroz duži period. To će nam također omogućiti stvaranje hipoteza o čimbenicima koji dovode do restenoze nakon ugradnje stenta.]]></summary_hr><summary_en><![CDATA[One of the main drawbacks of the currently used stents is balloon related injury of both arteries and stents, leading to in-stent restenosis. There is also extensive research being conducted on polymer bioresorbable stents, that would temporarily expand the luminal area while letting the artery heal, and then degrade over time. However, due to inferior mechanical properties of polymers compared to metals, struts of such stents need to be ticked, causing numerus problems and risks. Self-expanding 4D printed stents have a potential to reduce these shortcomings. Therefore, we propose experimental evaluation of medical effectiveness of such stent by deployment of 4D printed stent into stenosed silicone artery. Because mechanical behaviour of silicone not identical to that of an artery, numerical evaluation is also necessary. For that to be possible, constitutive model of 4D printed material is need. Thus, extensive mechanical testing will be conducted, and material model fitted. Stenting procedure will numerically be modelled, taking into account long-term growth and remodelling of artery. This will also enable us to hypothesis on factors leading to in-stent restenosis.]]></summary_en></project><project>
<id>15354</id><title_hr><![CDATA[Metabolizam serina, kurkumin i odgovor stanica raka na cisplatinu in vitro ]]></title_hr><title_en><![CDATA[Serine metabolism, curcumin and cancer cells response to cisplatin in vitro ]]></title_en><user_id>11305</user_id><user_firstLast_name>Koraljka Gall Trošelj</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-3690</code><acronim><![CDATA[CanSer]]></acronim><duration>22.12.2023 - 21.12.2027</duration><status>U tijeku</status><financ_value>174.756,12 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, Clinical sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>3536, 11317, 2554, 12722, 866040, 5359, 872633, </team_members_id><team_members_names><![CDATA[Mario Cindrić, Renata Novak Kujundžić, Nikola Đaković, Paško Konjevoda, Silvija Mašić, Ivana Samarzija, Sara Zvonar, ]]></team_members_names><keywords_hr><![CDATA[metaboličko reprogramiranje, stanica raka, metabolizam serina, osjetljivost na liječenje, kurkumin, cisplatina, epigenom]]></keywords_hr><keywords_en><![CDATA[metabolic reprogramming, cancer cell, serine metabolism, therapy sensitivity, curcumin, cisplatin, epigenome]]></keywords_en><summary_hr><![CDATA[Reprogramiranje metabolizma stanice raka ovisi o čimbenicima okoline, genetskom ustroju i organu podrijetla. Sinteza serina de novo, u koju su izravno uključena tri enzima: 3-fosfoglicerat dehidrogenaza (PHGDH), fosfoserin aminotransferaza (PSAT1) i fosfoserin fosfataza (PSPH), biosintetski je put koji stanici raka omogućuje stvaranje biomase, nukleotida i glutationa. Za aktivnost PHGDH neophodan je koenzim NAD+. Aktivnost PSAT1 dovodi do stvaranja alfa-ketoglutarata (AKG), o kojem ovisi aktivnost brojnih lizin-demetilaza histona i demetilaza DNA TET. Kurkumin senzibilizira stanicu u odgovoru na liječenje kemoterapeuticima. Pokazali smo da kurkumin potiče transkripciju PHGDH koja je praćena i porastom razine proteina PHGDH u stanicama podrijetlom od zloćudnih tumora glave i vrata. Najnoviji podatci u literaturi upućuju na povećanu osjetljivost na cisplatinu u tumorima jajnika koji imaju s pojačanu aktivnost PHGDH. Metodama funkcionalnih staničnih testova, mjerenjem razine aminokiselina i molekularno-genetičkim metodama, želimo istražiti remoduliranje razine transkripcije, sinteze i smještaja ključnih proteina vezanih uz biosintetski put serina de novo, u kurkuminu i/ili cisplatini izloženim, na cisplatinu različito osjetljivim, stanicama raka podrijetlom od tumora glave i vrata i debelog crijeva. Opažene fenomene povezat ćemo s terapijskim odgovorom kroz: a) mjerenje proliferacije i vijabilnosti stanica in vitro; b) selektivnim utišavanjam ključnih točaka signalnog puta b) praćenjem odgovora na liječenje u odnosu na ključne enzime i njihove regulatore u kliničkim uzorcima. Ključne regulatore signalne mreže odredili smo: a) na temelju rezultata završenog HRZZ projekta; b) preliminarnih rezultata i c) korištenjem baze TCGA i javno dostupnih računalnih programa. S obzirom na to da se dijeta siromašna serinom sve češće istražuje u terapijskim pristupima liječenjaraka, smatramo da će dobiveni rezultati značajno unaprijediti znanje u ovom području onkologije.]]></summary_hr><summary_en><![CDATA[Metabolic reprogramming of a cancer cell depends on environmental factors, the genetic background and the cell&#39;s lineage of origin. Three enzymes are directly involved in serine synthesis de novo: 3-phosphoglycerate dehydrogenase (PHGDH); phosphoserine aminotransferase (PSAT1); and phosphoserine phosphatase (PSPH). The activity of this pathway enables the cancer cell to create biomass, nucleotides and glutathione. The coenzyme NAD+ is necessary for the activity of PHGDH. The activity of PSAT1 leads to the formation of alpha-ketoglutarate, which is needed for activity of numerous histone lysine-demethylases and TET DNA demethylases. Curcumin sensitizes cancer cells response to chemotherapeutic agents. We showed that curcumin increases both, PHGDH mRNA and protein, in cells originating from malignant head and neck tumors. The latest literature data indicate an increased sensitivity to cisplatin in ovarian tumors with increased PHGDH activity. We propose to investigate the modulation of transcription, synthesis and localization of key proteins relating to the serine biosynthetic pathway, in curcumin or/and cisplatin exposed cancer cells originating from head and neck tumors and colon tumors. We plan to use functional cellular analyses, measure the level of amino acids and apply appropriate molecular genetic methods. The importance of phenomena obtained will be estimated through: a) measurement of cellular proliferation and viability in vitro; b) selective silencing of critical hubs of the network b) monitoring response to treatment with respect to expression of selected enzymes, in the clinical samples. The key network regulators were determined: a) based on the results of the completed HRZZ project; b) preliminary results and c) using the TCGA database and publicly available software. A diet low in serine is increasingly being investigated in approaches to cancer treatment, the obtained results will significantly improve knowledge in this field of molecular oncology.]]></summary_en></project><project>
<id>15359</id><title_hr><![CDATA[Aero- i hidrodinamičko poboljšanje ekološki prihvatljivih energetskih sustava]]></title_hr><title_en><![CDATA[Aero- and hydrodynamic enhancement of environmentally friendly energy systems]]></title_en><user_id>4960</user_id><user_firstLast_name>Hrvoje Kozmar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-9434</code><acronim><![CDATA[AHEFES]]></acronim><duration>15.12.2023 - 14.12.2027</duration><status>U tijeku</status><financ_value>198.820,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, Građevinarstvo, Temeljne tehničke znanosti, Interdisciplinarne tehničke znanosti, </scie_field_hr><scie_field_en>Mechnical engineering, Civil engineering, Basic engineering sciences, Interdisciplinary technological sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>866021, 17884, 865924, 865421, 865921, 29416, 866193, 866027, 865906, 871743, 871801, 873054, </team_members_id><team_members_names><![CDATA[Guenter Brenn, Andrija Buljac, Christoph Irrenfried, Marin Ivanković Ivanković, Matko Jelašić, Petar Škvorc, Ahsan Kareem Kareem, Christian Nayeri, Wenxian Yang, Marija Rešetar, Ivan Marušić, Krunoslav Drašković, ]]></team_members_names><keywords_hr><![CDATA[Mehanika fluida, aerodinamika, obnovljivi izvori energije, okoliš, prirodna ventilacija zgrade, aerodinamika aeroprofila]]></keywords_hr><keywords_en><![CDATA[Fluid mechanics, aerodynamics, renewable energy, environment, natural building ventilation, aerodynamics of airfoils]]></keywords_en><summary_hr><![CDATA[Predloženi projekt je usmjeren na tri teme vrlo relevantne za aerodinamičko i hidrodinamičko poboljšanje ekološki prihvatljivih energetskih sustava, tj. a) prirodnu ventilaciju zgrada, b) opterećenja okoliša na pučinske vjetroturbine, c) aerodinamički oblik lopatica vjetroturbina. Aktivnosti će se provoditi eksperimentalno u najsuvremenijim laboratorijima na a) Tehničkom sveučilištu u Grazu, Austrija, b) Sveučilištu Newcastle, UK, c) Tehničkom sveučilištu u Berlinu, Njemačka. Potrebna mjerna oprema postoji u ovim ustanovama i pokazala se prikladnom u prethodnim istraživanjima. Ciljevi su raspoređeni u tri radna paketa kako bi istražili a) učinak visoke zgrade i terminala zračne luke na prirodnu ventilaciju zgrade, b) učinak različitih vrsta valova na pučinske vjetroturbine, c) aerodinamičke značajke generatora vrtloga i Gurney zakrilca na aeroprofilima. Istraživačka grupa se sastoji od deset članova, mlađih i starijih istraživača iz Hrvatske i inozemstva, čime nudi jedinstven spoj prilagođen za postizanje zadanih ciljeva. Ukupan rezultat istraživanja je najmanje šest članaka u vodećim časopisima i šest konferencijskih radova. Rezultati će koristiti društvu i gospodarstvu s obzirom na dulji životni vijek pučinskih vjetroturbina. Poboljšana aerodinamika aeroprofila će omogućiti povećanje energije iskorištene iz vjetra i manje emisije CO2, čime će pogodovati okolišu. Nova saznanja oko prirodne ventilacije zgrada će omogućiti bolju ventilaciju unutarnjih prostora što će smanjiti potrebu za energijom stvorenom pomoću mehaničkih uređaja i poboljšati zdravlje ljudi u zatvorenim prostorima, što je posebno poželjno u trenutnoj pandemiji. Korisnici rezultata su u sektoru obnovljivih izvora energije, uključujući strojarstvo, građevinarstvo, i energetiku, uz zdravstvene stručnjake u epidemiologiji i toksikologiji, čime se nude jasne koristi za različite istraživačke zajednice i stručnjake iz prakse.]]></summary_hr><summary_en><![CDATA[The proposed project focuses on three topics highly relevant to aerodynamic and hydrodynamic enhancement of environmentally friendly energy systems, i.e. a) natural building ventilation, b) environmental loads on offshore wind turbines, c) aerodynamic design of wind-turbine blades. The activities will be performed experimentally in state-of-the art facilities at a) Graz University of Technology, Austria, b) Newcastle University, UK, c) Technical University of Berlin, Germany. The experimental technique is readily available in these facilities and proved suitable in previous studies. Research objectives are arranged in three work packages to respectively address a) the effect of a tall building and an airport terminal on the natural building ventilation, b) the effect of various waves’ types on offshore wind turbines, c) the aerodynamic performance of Vortex Generators and Gurney Flap on airfoils. The research group consists of ten members, junior and senior researchers from Croatia and abroad, thus offering a unique blend perfectly suited to achieve the intended goals. The total research output is at least six journal articles in leading journals and six conference contributions. The results will benefit the society and economy given the longer life of offshore wind turbines. The improved aerodynamics of airfoils will allow for more energy harnessed from the wind and less CO2 emissions, thus benefiting the environment. The natural building ventilation findings will allow for better ventilation of indoor spaces that will reduce the need for energy created using mechanical devices and enhance human health in indoor spaces, which is particularly desired in the current pandemic. The users of the results are in the renewable energy sector, including mechanical, civil, ocean, and energy engineering, in addition to health professionals in epidemiology and toxicology, thus offering clear benefits for various research communities and practicing experts.]]></summary_en></project><project>
<id>15361</id><title_hr><![CDATA[Dizajni, grafovi i kodovi]]></title_hr><title_en><![CDATA[Designs, Graphs and Codes]]></title_en><user_id>885</user_id><user_firstLast_name>Dean Crnković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-4571</code><acronim><![CDATA[DeGraCo]]></acronim><duration>30.12.2023 - 29.12.2027</duration><status>U tijeku</status><financ_value>140.686,17 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Fakultet za matematiku]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Mathematics]]></institution_en><team_members_id>919, 4515, 907, 28994, 3468, 3226, 3161, 1089, 23476, 3906, 23513, 23496, 865728, 23495, 865712, 868741, </team_members_id><team_members_names><![CDATA[Sanja Rukavina, Andrea Švob, Vedrana Mikulić Crnković, Daniel Hawtin, Nina Mostarac, Marina Šimac, Marija Maksimović, Doris Dumičić Danilović, Sara Ban, Ana Grbac, Matteo Mravić, Ivona Traunkar, Ana Šumberac, Tin Zrinski, Matea Zubović, Nour Alnajjarine, ]]></team_members_names><keywords_hr><![CDATA[Kombinatorički dizajn, graf, kod, konačna grupa, asocijacijska shema, Hadamardova matrica]]></keywords_hr><keywords_en><![CDATA[Combinatorial design, graph, code, finite group, association scheme, Hadamard matrix]]></keywords_en><summary_hr><![CDATA[U projektu će se uglavnom provoditi istraživanja u području algebarske teorije dizajna i algebarske teorija grafova, a također će se projekt baviti proučavanjem kodova, posebno algebarskom teorijom kodiranja. U području teorije dizajna projekt će se između ostalog baviti konstrukcijom kombinatoričkih dizajna iz konačnih grupa. Takva istraživanja, uz doprinos teoriji dizajna, doprinose i boljem razumijevanju konačnih grupa. Posebno će se proučavati dizajni na koje djeluju konačne jednostavne grupe, čije je proučavanje od ključne važnosti u teoriji grupa. Dizajni će se konstruirati i na druge načine, koristeći linearne kodove i heurističke metode. Također će se proučavati Hadamardove matrice, koje su usko vezane za kombinatoričke dizajne. Hadamardove matrice imaju brojne primjene, npr. u fizici, teoriji kodiranja, obradi signala i spektrometriji, što daje dodatnu važnost njihovom proučavanju. U proučavanju grafova i usmjerenih grafova posebno će se posvetiti pažnja regularnim grafovima, npr. jako regularnim i ostalim distancijsko regularnim grafovima te kvazi jako regularnim grafovima i digrafovima. Također će se proučavati asocijacijske sheme, koje su usko vezane za distancijsko regularne grafove. Proučavanje distancijsko regularnih grafova i asocijacijskih shema centralni je dio algebarske teorije grafova. Kod proučavanja grafova i digrafova posvetit će se pažnja njihovim grupama automorfizama. Posebno će se proučavati grafovi na koje djeluju konačne jednostavne grupe. Kod istraživanja u teoriji kodiranja posebno će se proučavati razne vrste linearnih kodova nad poljima i prstenovima, a također i kodovi definirani na grafovima koji imaju tranzitivne grupe automorfizama koje djeluju tranzitivno i na skupu susjeda koda. Proučavat će se veza između kodova i kombinatoričkih dizajna, grafova i asocijacijskih shema.  Također će se proučavati q-analogoni dizajna i grafova, njihove grupe automorfizama te pripadni kodovi potprostora. ]]></summary_hr><summary_en><![CDATA[The project will mainly conduct research in the field of algebraic design theory, algebraic graph theory, and the study of codes, especially in the field of algebraic coding theory. In the field of design theory, the project will deal, among other things, with the construction of combinatorial designs from finite groups. Such research, in addition to contributing to design theory, also contributes to a better understanding of finite groups. In particular, we will study the designs on which finite simple groups act, since the study of the finite simple groups is of crucial importance in group theory. Designs will be constructed in other ways as well, e.g. using linear codes and heuristic methods. Hadamard matrices, which are closely related to combinatorial designs, will also be studied. Hadamard matrices have numerous applications, for example in physics, coding theory, signal processing and spectrometry, which gives additional importance to their study. In the study of graphs and directed graphs, special attention will be paid to regular graphs, e.g. strongly regular and other distance-regular graphs and quasi-strongly regular graphs and digraphs. Association schemes, which are closely related to distance-regular graphs, will also be studied. The study of distance regular graphs and association schemes is a central part of algebraic graph theory. When studying graphs and digraphs, special attention will be paid to their automorphism groups. In particular, graphs on which finite simple groups act will be studied. In the course of research in coding theory, various types of linear codes over fields and rings will be studied, as well as codes defined on graphs that have transitive and neighbour-transitive groups of automorphisms. The connection between codes and combinatorial designs, graphs and association schemes will be studied. Further, q-analogues of designs and graphs, their automorphism groups and associated subspace codes will be studied. ]]></summary_en></project><project>
<id>15362</id><title_hr><![CDATA[Kako starost centrosoma utječe na stvaranje, popravak i segregaciju polarnih kromosoma]]></title_hr><title_en><![CDATA[How centrosome age affects the formation, resolution, and fate of polar chromosomes]]></title_en><user_id>11207</user_id><user_firstLast_name>Iva Tolić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IPCH</proposal_type><proposal_call>2022-10</proposal_call><code>IPCH-2022-10-9344</code><acronim><![CDATA[CentroPol]]></acronim><duration>01.06.2023 - 31.05.2027</duration><status>U tijeku</status><financ_value>193.786,41 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, Fizika, </scie_field_hr><scie_field_en>Biology, Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>6276, 866270, 870863, 868278, 868216, </team_members_id><team_members_names><![CDATA[Nenad Pavin, Valentina Štimac, Adrian Perhat, Mario Đura, Lovro Gudlin, ]]></team_members_names><keywords_hr><![CDATA[diobeno vreteno, starost centrosoma, segregacija kromosoma, mikrotubuli, pivotiranje mikrotubula, Cenexin, sub-distalni dodaci, kinezin-5]]></keywords_hr><keywords_en><![CDATA[mitotic spindle, centrosome age, chromosome segregation, microtubules, microtubule pivoting,  Cenexin, sub-distal appendages, kinesin-5]]></keywords_en><summary_hr><![CDATA[Ljudske stanice koje se dijele suočavaju se s dva ključna suprotstavljena zadatka: vjerno odvajanje sestrinskih kromatida uz izbjegavanje dugih kašnjenja u mitozi. Diobeno vreteno brzo pričvršćuje i poravnava većinu kromosoma na metafaznoj ploči, ali polarni kromosomi koji se nalaze iza polova vretena u nastajanju predstavljaju poseban izazov. Nedavni rad u laboratoriju Tolić pokazao je da su polarni kromosomi posebno skloni pogrešnom razdvajanju u stanicama raka. Međutim, slabo je poznato kako se polarni kromosomi stvaraju i popravljaju. Zanimljivo je da dva pola vretena nisu jednaka u svojoj sposobnosti popravljanja polarnih kromosoma, budući da je rad laboratorija Meraldi utvrdio da pol koji sadrži stari centrosom nakuplja više polarnih kromosoma. Stoga je središnja hipoteza ovog projekta da starost centrosoma utječe na stvaranje, popravak i razdvajanje polarnih kromosoma. Glavni je cilj ovog zajedničkog istraživanja otkriti molekularne i biofizičke mehanizme koji kontroliraju polarne kromosome, kombinirajući stručnost laboratorija Meraldi u asimetrijama ovisnima o starosti centrosoma i laboratorija Tolić u biomehanici polarnih kromosoma. Istraživat ćemo i mijenjati parametre diobenog vretena koji utječu na polarne kromosome u ljudskim staničnim linijama s velikim spektrom asimetrija polarnih kromosoma te u fiziološkom kontekstu neuroblasta Drosophile. Ovaj će projekt sinergijski iskoristiti stručnost razvijenu u oba laboratorija, uključujući najmodernije metode snimanja živih stanica, mikroskopiju visoke razlučivosti, lasersku ablaciju, kao i teorijsko modeliranje u suradnji s Nenadom Pavinom. Rezultati će otkriti mehaničku vezu između početnog položaja kromosoma u odnosu na stari i mladi centrosom s točnošću njihovog razdvajanja, što će omogućiti razumijevanje podrijetla važnog uzroka grešaka u podjeli kromosoma u stanicama raka.]]></summary_hr><summary_en><![CDATA[Dividing human cells face two key competing tasks: faithfully segregating sister chromatids while avoiding long mitotic delays. The mitotic spindle rapidly attaches and aligns most chromosomes on the metaphase plate, but polar chromosomes, which start behind the emerging spindle poles, offer a particular challenge. Recent work in the Tolić laboratory showed that polar chromosomes are especially prone to being mis-segregated in cancer cells. How polar chromosomes are formed and resolved is, however, poorly understood. Interestingly, the two spindle poles are not equal in their ability to deal with polar chromosomes, as work of the Meraldi laboratory has established that the pole containing the old centrosome accumulates more polar chromosomes. Thus, the central hypothesis of this project is that centrosome age affects the formation, resolution, and fate of polar chromosomes. The main goal of this collaborative effort is to decipher the molecular and biophysical mechanisms controlling polar chromosomes, by combining the expertise of the Meraldi laboratory in centrosome age-dependent asymmetries and the Tolić laboratory in the biomechanics of polar chromosomes. We will investigate and manipulate the spindle parameters affecting polar chromosomes in human cell lines with a large spectrum of polar chromosomes asymmetries, and in a physiological context of Drosophila neuroblasts. This project will synergistically benefit from the expertise developed in both laboratories, including cutting-edge live-cell imaging assays, super-resolution microscopy, laser ablation, as well as theoretical modelling in collaboration with Nenad Pavin. Overall, the project will reveal a mechanistic link between the initial location of the chromosomes with respect to the old and young centrosome with the accuracy of their segregation, providing understanding of the origin of a prominent cause of chromosome segregation errors in cancer cells.]]></summary_en></project><project>
<id>15365</id><title_hr><![CDATA[Koliko je CRISPR adaptacija prilagodljiva na uvjete okoliša? Utjecaj DNA helikaza.]]></title_hr><title_en><![CDATA[How is CRISPR adaptation tuned to environment conditions? Mechanism from DNA helicases.]]></title_en><user_id>4503</user_id><user_firstLast_name>Ivana Ivančić Baće</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-7882</code><acronim><![CDATA[ADAPT]]></acronim><duration>15.12.2023 - 14.12.2027</duration><status>U tijeku</status><financ_value>158.470,84 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>5173, 867652, 869633, 25303, </team_members_id><team_members_names><![CDATA[Edward Bolt, Tomislav Mamić, Mirta Žagar, Damjan Mitić, ]]></team_members_names><keywords_hr><![CDATA[CRISPR-Cas, adaptacija, helikaze, E. coli, temperatura]]></keywords_hr><keywords_en><![CDATA[CRISPR-Cas, adaptation, helicases, E. coli, temperature]]></keywords_en><summary_hr><![CDATA[Sustav CRISR-Cas (Clustered Regularly Interspaced Short Palindromic Repeats -  CRISPR associated) adaptivne imunosti predstavlja mehanizam obrane prokariota od infekcije stranom DNA poput faga i plazmida. Sastoji se od lokusa CRISPR koji sadrži ponavljajuće palindromske sekvence DNA odvojene razmaknicama koje potječu od strane DNA, te gena cas čijom ekspresijom nastaju proteini koji sudjeluju u svim fazama obrane. Ugradnjom novih razmaknica u lokus CRISPR bakterija „pamti“ stranu DNA, čime postaje imuna na ponovnu infekciju sa istom stranom DNA. Proces ugradnje fragmenta strane DNA (razmaknice) u lokus CRISPR naziva se adaptacija, i ujedno je prvi i ključni korak u stvaranju CRISPR-Cas imunosti. U sustavu tipa IE bakterije Escherichia coli razlikujemo dva načina adaptacije – naivnu i pripremljenu. U naivnoj adaptaciji fragmenti strane DNA se ugrađuju po prvi put, i u tom procesu je neophodan kompleks Cas1-Cas2 i određeni proteini domaćina (enzim RecBCD) koji veliku stranu DNA cijepaju na manje fragmente. U pripremljenoj adaptaciji uzima se nova razmaknica iz iste strane DNA kako bi se obnovio imunitet pri ponovnom susretu. Osim kompleksa Cas1-Cas2, u pripremljenoj adaptaciji sudjeluju i proteini interferencije kompleks Cascade i protein Cas3.Mehanizam ugradnje strane DNA u lokus CRISPR pomoću kompleksa Cas1-Cas2 detaljno je istražen i poznat, dok su uloge drugih proteina domaćina ili utjecaja fiziologije bakterije na stvaranja fragmenata DNA je manje poznati. Ciljevi ovog projekta su otkriti ostale helikaze koje su uključene u izgradnju CRISPR-Cas imunosti procesom naivne adaptacije, te razjasniti utjecaj temperature i fiziologije stanica na obnavljanje imunosti procesom pripremljene adaptacije.]]></summary_hr><summary_en><![CDATA[Clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated (Cas) proteins constitutes an adaptive immune system in bacteria and archaea against viruses and plasmids. It consists of the CRISPR locus, which contains repetitive palindromic sequences separated by variable ‘spacer’ sequences that originate from viruses and plasmids (protospacers), and the Cas proteins that play roles in the different stages of immunity. By incorporating new spacers into the CRISPR locus, bacteria preserve molecular memories of infections and becomes immune to re-infection with matching foreign DNA. Two modes of adaptation have been reported in Escherichia coli type IE system: naive and primed. During the naive adaptation, the spacers are directly obtained from a foreign DNA source for the first time, using the Cas1-Cas2 complex and certain host proteins (RecBCD enzyme) that cleave the large foreign DNA into smaller fragments. In primed adaptation the pre-existing spacer is required to enable enhanced uptake of new spacers from the same foreign DNA in order to restore immunity. In addition to Cas1 and Cas2, primed adaptation requires interference complex Cascade and Cas3 protein.The molecular mechanism of incorporation of foreign DNA fragments into the CRISPR locus using the Cas1-Cas2 complex has been thoroughly investigated and known, while the roles of other host proteins or the influence of bacterial physiology in generation of DNA fragments are less well known. The aims of this project are to uncover other host helicase(s) that are involved in generation of CRISPR-Cas immunity through the process of naive adaptation, and elucidate the influence of temperature and cell physiology on updating immunity through the process of primed adaptation.]]></summary_en></project><project>
<id>15369</id><title_hr><![CDATA[Evolucija složenih magnetskih i polarnih uređenja iz jednostavnih 2D podstruktura u slojevitim hibridnim organsko-anorganskim halogenometalatima]]></title_hr><title_en><![CDATA[Evolution of the complex magnetic and polar orders from simple 2D scaffolds in the layered hybrid organic-inorganic halometallates]]></title_en><user_id>2787</user_id><user_firstLast_name>Damir Pajić</user_firstLast_name><svouser_id>866154</svouser_id><svouser_firstLast_name>Andrej Zorko</svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-6321</code><acronim><![CDATA[HOI2DEM]]></acronim><duration>31.12.2023 - 30.12.2027</duration><status>U tijeku</status><financ_value>192.102,95 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, Kemija, </scie_field_hr><scie_field_en>Physics, Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>29030, 634, 27133, 946, 23623, 2752, 866128, 47, 5693, 869812, 872865, 874011, </team_members_id><team_members_names><![CDATA[Dario Barišić, Mirta Rubčić, Edi Topić, Ivica Đilović, Denis Stanić, Emil Tafra, Metodija Najdoski, Marina Cindrić, Krešo Zadro, Nikola Miše, Rafikul Hussain, Marko Bochniček, ]]></team_members_names><keywords_hr><![CDATA[2D materijali, hibridna struktura, magnetsko uređenje, feroelektrici, magnetoelektrici, magnetotransport, foto- i opto-magnetizam, nered]]></keywords_hr><keywords_en><![CDATA[2D materials, hybrid structure, magnetic order, ferroelectrics, magnetoelectrics, magnetotransport, photo- and opto-magnetism, disorder]]></keywords_en><summary_hr><![CDATA[Sustavi u kojima se javljaju magnetska i polarna uređenja od velikog su zanimanja u fizici i kemiji kondenzirane materije, a dvodimenzionalni (2D) materijali postali su strateški za područja elektronike/spintronike, fotonike, energetike, biomedicine. U okviru projekta razvijat će se novi hibridni organsko-anorganski halogenometalati(II), HOAH, slojevitih struktura koji bi se odlikovali složenim magnetskim i polarnim uređenjima, s ciljem ostvarenja multiferoičnosti, te prema mogućnostima magneto-električnog vezanja. Razvoj će teći uvođenjem funkcionalnih kiralnih i/ili asimetričnih organskih kationa te dopiranjem/supstitucijom pojedinih strukturnih podjedinica u HOAH sustavima. Polarna uređenja kao i lokalna simetrija strukturnih podjedinica utvrdit će se difrakcijskim tehnikama i spektroskopskim analizama te električnim mjerenjima. Eksperimentalno će se rigorozno istražiti magnetska uređenja ili nered, kako globalno pomoću magnetizacije i izmjenične susceptibilnosti, tako i lokalno pomoću elektronske i nuklearne spinske te kvadrupolne rezonancije. Potkrjepa kvantno-mehaničkim ab-initio računima upotpunit će saznanja o električnoj polarizaciji i magnetskim međudjelovanjima. Za odabrane faze HOAH sustava istražit će se strukturni i magnetski odziv na vanjske parametre (električno polje, tlak, svjetlost) što će pružiti saznanja o uspostavi egzotičnih stanja te dati dodatni uvid u mehanizme superizmjene. Provest će se i magneto-transportna te optička istraživanja radi širenja puteva prema primjeni u opto-magneto-elektronici. Odabrani HOAH priredit će se i karakterizirati u obliku tankih filmova, jer je njihov razvoj nužan radi ugradnje u nano-uređaje. Razvit će se element temeljen na spoju tankog filma HOAH i vodljivog polimera, gdje će se naponskim vratima nastojati izazvati promjenu magnetskog, električnog i/ili optičkog stanja. Istraživanje u ovako multidisciplinarnom timu rasvijetlit će neka pitanja o HOAH kao (kvazi)2D materijalima.]]></summary_hr><summary_en><![CDATA[Systems in which magnetic and polar orders occur are of great interest in condensed matter physics and chemistry, and two-dimensional (2D) materials have become strategic for the fields of electronics/spintronics, photonics, energy, biomedicine. Within the project, new hybrid organic-inorganic halometallates(II), HOAH, will be developed, with layered structures that would have complex magnetic and polar orders, with the aim of achieving multiferroicity, and possibly magnetoelectric coupling. Development will proceed with the implementation of functional chiral and/or asymmetric organic cations and doping/substitution of individual structural scaffolds in HOAH systems. Polar order as well as local symmetry of structural units will be determined by diffraction and spectroscopic techniques, and electrical measurements. Magnetic properties will be rigorously investigated experimentally, both with study of bulk magnetization and AC susceptibility, and locally, using electron and nuclear spin and quadrupole resonance.  Ab-initio calculations will complement the experimental results. For selected HOAH phases, the structural and magnetic response to external parameters (electric field, pressure, light) will be investigated, which will provide knowledge about the formation of exotic states and additional insight into super-exchange mechanisms. Magneto-transport and optical research will be conducted in order to pave the way towards application in opto-magneto-electronics. The selected HOAHs will be prepared and characterized in the thin film form, since their development is crucial for the integration into nano-devices. A device based on the junction of a thin film of HOAH with a functional substrate will be developed, where a voltage gate would be used to manipulate the magnetic, electrical and/or optical state. Research in such a multidisciplinary team will elucidate some aspects about HOAH as (quasi)2D materials.]]></summary_en></project><project>
<id>15370</id><title_hr><![CDATA[Interaktivni učinci mikroplastike i nanosrebra na kopnene i vodene biljke i alge ]]></title_hr><title_en><![CDATA[MIcroplastic and Nanosilver InteractiONs in terrestrial and freshwater plants and algae]]></title_en><user_id>11303</user_id><user_firstLast_name>Biljana Balen</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-3824</code><acronim><![CDATA[MINION]]></acronim><duration>15.12.2023 - 14.12.2027</duration><status>U tijeku</status><financ_value>197.093,31 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, Kemija, </scie_field_hr><scie_field_en>Biology, Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>4710, 12729, 3121, 4614, 12785, 21315, 858380, 25965, 866008, 869688, 23301, 873059, 865804, </team_members_id><team_members_names><![CDATA[Mirta Tkalec, Petra Peharec Štefanić, Dubravko Pavoković, Petra Cvjetko, Sandra Šikić, Renata Biba, Bruno Komazec, Bernarda Marković, Daniel Hadraba Hadraba, Dorian Loknar, Nino Dimitrov, Dona Vuković, Karlo Miškec, ]]></team_members_names><keywords_hr><![CDATA[mikroplastika, nanočestice srebra, fitotoksičnost, oksidacijski stres, fotosinteza, (gliko)proteini, Allium, Lemna, Chlorella]]></keywords_hr><keywords_en><![CDATA[microplastics, silver nanoparticles, phytotoxicity, oxidative stress, photosynthesis, (glyco)proteins, Allium, Lemna, Chlorella]]></keywords_en><summary_hr><![CDATA[Potražnja za plastikom kontinuirano raste u različitim područjima ljudskih aktivnosti, a velik dio proizvedene plastike završava u okolišu kao otpad, stvarajući tako značajan ekološki izazov. Budući da nije biorazgradiva, plastika ostaje u okolišu jako dugo pa je plastični otpad pod kontinuiranim procesom razgradnje koji dovodi do fragmentacije plastike na manje dijelove, od većih plastičnih ostataka do mikro (MP) i nano (NP) ) dimenzija čestica. Čestice plastike ostaju u kopnenom i vodenom okolišu te u atmosferi i time ugrožavaju živi svijet. Dimenzije plastike i njezina sposobnost adsorpcije toksičnih organskih i anorganskih zagađivača, kao i osnovna struktura polimera, ključne su varijable u određivanju razine toksičnosti plastike u izloženim organizmima. Posebno su zanimljive studije koje se bave interakcijama između MP i nanočestica metala, posebice nanočestica srebra (AgNP), zbog njihove široke rasprostranjenosti u tlu, vodi i zraku te njihove toksičnosti za većinu organizama. U našem projektu predlažemo inovativno istraživanje o interaktivnim učincima MP i AgNP na biljke i zelene alge, ključne komponente svakog ekosustava i prehrambenog lanca. U projektu ćemo istražiti dvije vrste mikroplastike (PS-MP i PMMA-MP) i AgNP s dvije vrste omotača (PVP- i CTAB-AgNP) na kopnenoj biljci Allium cepa, vodenoj biljci Lemna minor i zelenoj algi Chlorella vulgaris kako bi se razjasnila priroda njihove interakcije i o čemu ona ovisi. Štoviše, predloženi su inovativni pristupi lokalizaciji i detekciji MP. Saznanja o interakcijama MP i AgNP općenito su vrlo skromna, a za biljke i zelene alge do sada postoji samo jedna objavljena studija.]]></summary_hr><summary_en><![CDATA[The demand for plastic is continuously growing in various areas of human activity and large amounts of plastic end up in the environment as waste, thus creating a significant environmental challenge. Being non-biodegradable, plastic remains in the environment for a very long time and therefore plastic waste is under a continuous process of degradation that leads to the fragmentation of plastic into smaller parts, from larger plastic debris to micro (MP) and nano (NP) dimension of particles. Plastic particles remain in the land and water environment and in the atmosphere, thus endangering the living world. The dimensions of the plastic and its ability to adsorb toxic organic and inorganic pollutants, as well as the basic structure of the polymer, are key variables in determining the level of plastic toxicity in exposed organisms. Particularly interesting are studies dealing with interactions between MP and metal nanoparticles, especially silver nanoparticles (AgNPs), due to their worldwide distribution in soil, water and air, and their toxicity to most organisms. In our project, we propose innovative research on the interactive effects of MP and AgNP on plants and green algae, key components of every ecosystem and food chain. In the project we will investigate two types of microplastics (PS-MP and PMMA-MP) and AgNPs with two types of coatings (PVP- and CTAB-AgNPs) on the terrestrial plant Allium cepa, aquatic plant Lemna minor, and the green alga Chlorella vulgaris to elucidate the nature of their interactions and what it depends on. Moreover, the innovative approaches to MP localization and detection are proposed. Knowledge about the interactions of MPs and AgNPs is generally very modest, and for plants and green algae there is only one published study so far. ]]></summary_en></project><project>
<id>15371</id><title_hr><![CDATA[Motivacije i prepreke za kolektivne akcije]]></title_hr><title_en><![CDATA[Motivators and Barriers for Collective Action]]></title_en><user_id>3880</user_id><user_firstLast_name>Renata Franc</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-2803</code><acronim><![CDATA[MOTIKA]]></acronim><duration>31.12.2023 - 30.12.2027</duration><status>U tijeku</status><financ_value>114.631,16 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Psihologija, Politologija, Sociologija, </scie_field_hr><scie_field_en>Psychology, Political Science, Sociology, </scie_field_en><institution_hr><![CDATA[Institut društvenih znanosti Ivo Pilar]]></institution_hr><institution_en><![CDATA[Institute of Social Sciences Ivo Pilar in Zagreb]]></institution_en><team_members_id>866145, 25218, 18992, 865317, 2727, 24257, 6362, 866313, 866324, 866370, 866447, 873018, </team_members_id><team_members_names><![CDATA[Marina Maglić, Tomislav Pavlović, Zoran Sušanj, Ana Jakopec, Ines Sučić, Benjamin Perasović, Ivana Vrselja, HILARY PILKINGTON, Vanja Dergić, Roger Soler-i-Marti, Marko Mustapić, Iva Sušilović, ]]></team_members_names><keywords_hr><![CDATA[SIMCA model, doživljaj nepravde, efikasnost, identitet, normativne kolektivne akcije, nenormativne kolektivne akcije, nasilne i nenasilne KA]]></keywords_hr><keywords_en><![CDATA[SIMCA model, injustice,  efficacy, identity, normative collective action, nonnormative collective action, violent and peacefull collective action]]></keywords_en><summary_hr><![CDATA[Opći cilj projekta je utvrditi i istražiti motivacije i prepreke za sudjelovanje u različitim oblicima kolektivnih akcija (odnosno akcija radi unaprjeđenja interesa grupe ili zbog političke solidarnosti ) u hrvatskom kontekstu. Socijalno identitetski model KA kao tri temeljna motivatora KA ističe: izraženu socijalnu, osobito politiziranu identifikaciju, izraženi doživljaji nepravde te izraženu grupnu efikasnost. Usprkos brojnim potvrdama ovog i sličnih modela, ističe se i veći broj ograničenja, primjerice : zanemarivanje istraživanja sličnosti i razlika u motivatorima i preprekama za  sudjelovanje u različitim oblicima KA (npr. mirne ili nasilne),  zanemarivanje istraživanja različitih dimenzija doživljaja nepravde i percepcije efikasnosti, potom prepreka za sudjelovanjem u KA te uloge osobnih dispozicija. Projekt će koristi miješani istraživački pristup uz eksplorativno sekvencijalni nacrt . Prvo ćemo koristiti kvalitativnu metodu (polustrukturirani intervju s uzorkom građana N=25 i članova udruga N=25) pa kvantitativnu (online panel anketa u tri vala;  nacionalni reprezentativni kvotni uzorak s obzirom na dob, spol i obrazovanje: NT1 = 3120, NT2 = 1560, NT3 = 780) i prigodni uzorak članova udruga: NT1 = 1000, NT2 = 700, NT3 = 500). Prije prvog vala online anketiranja, provest ćemo dva pilot-istraživanja na prigodnim uzorcima studenata (N = 250 po istraživanju). Uz znanstveni doprinos, rezultati i spoznaje projekta imat će i  praktične implikacije za donositelje javnih politika (za programe i politike povezane sa poticanjem građanskog sudjelovanja te prevenciju nasilnih oblika kolektivnog djelovanja) te za voditelje i članove udruga (za privlačenje novih članova, mobilizaciju građana i članova kao i osnovu za eventualne prijedloge prema donositeljima javnih politika u smislu mogućih promjena za smanjivanje i uklanjanje prepreka za sudjelovanje u mirnim KA u hrvatskom kontekstu).]]></summary_hr><summary_en><![CDATA[The main goal of this project is to determine and investigate motivations and barriers for participation in different forms of collective actions (actions that are pursued with the aim of achieving group goals or political solidarity). The Social Identity Model of Collective Actions points out three fundamental motivators of CA: salient social and politicized identification, a strong feeling of injustice and strong group efficacy. Regardless of the rich empirical evidence for this and similar models, several limitations are highlighted, such as insufficient attention devoted to exploring the similarities and differences in motivators and barriers of different form of CA, to the determinants of nonparticipation – psychological barriers, different dimensions of the perceived injustice and efficacy and the potential role of dispositions. A mixed method approach and exploratory sequential design will be used, in which semi-structured interviews with participants from two samples (general public N=25; members of NGOs N025) will precede three wave online survey (nacional representative a quota sample NT1 = 3120, NT2 = 1560, NT3 = 780 and a convenient sample of members of NGOs members; NT1 = 1000, NT2 = 700, NT3 = 500). In addition to the common scientific knowledge, the project&#39;s results and expertise will be available for public policymakers to develop programs and policies related to encouraging citizen participation and preventing violent forms of CAs. NGO leaders and members will also be able to use the gained knowledge to attract new members and mobilize citizens and NGO members. Also, they will be able to use project findings in advocacy meetings with public policy makers when proposing ways to reduce and remove barriers to participation in peaceful CA in the Croatian context. ]]></summary_en></project><project>
<id>15379</id><title_hr><![CDATA[Otkrivanje biomarkera za bolest Hashimotov tireoiditis koristeći multi-omics pristup]]></title_hr><title_en><![CDATA[Biomarker discovery using multi-omics profiles in Hashimoto&#39;s thyroiditis]]></title_en><user_id>63</user_id><user_firstLast_name>Vesna Boraska Perica</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-4071</code><acronim><![CDATA[HT-OMICS]]></acronim><duration>31.12.2023 - 30.12.2027</duration><status>U tijeku</status><financ_value>199.084,21 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, Kliničke medicinske znanosti, Javno zdravstvo i zdravstvena zaštita, </scie_field_hr><scie_field_en>Basic Medical Sciences, Clinical sciences, Public health and health services, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Split School of Medicine]]></institution_en><team_members_id>22517, 3571, 260, 26007, 611, 26009, 866022, 865860, 869673, 872907, </team_members_id><team_members_names><![CDATA[Dean Kaličanin, Ante Punda, Ana Barić, Marko Vuletić, Vesela Lovrić Torlak, Maja Cvek Bobić, Eleftheria Zeggini, So Youn Shin, Vanna Žnidar, Ivana Listeš, ]]></team_members_names><keywords_hr><![CDATA[Hashimotov tireoiditis, multi-omics, genetika, proteomika, metabolomika, biomarkeri, Mendelova randomizacija, zonulin]]></keywords_hr><keywords_en><![CDATA[Hashimoto&#39;s thyroiditis, multi-omics, genetics, proteomics, metabolomics, biomarkers, Mendelian randomisation, zonulin]]></keywords_en><summary_hr><![CDATA[Hashimotov tireoiditis (HT) je najučestalija autoimuna bolest današnjice. Molekularni mehanizmi koji stoje u podlozi bolesti još uvijek nisu dovoljno poznati, stoga je ovaj projekt usmjeren na otkrivanje novih znanja o molekularnim i biološkim putovima vezanim uz HT. Ovaj projekt predstavlja nastavak prethodne HRZZ Uspostavne potpore u kojoj je osnovana CRO-HT biobanka bioloških uzoraka i fenotipova za 500 ispitanika oboljelih od HT-a te je na njima provedena cjelogenomska analiza povezanosti (GWAS). U međuvremenu smo prikupili još 200 kontrolnih ispitanika te u predloženom projektu kroz cilj 1 (C1 Proširenje CROHT biobanke) planiramo uključiti dodatnih 200 ispitanika s HT-om te genotipizirati njihov genom. Također, planiramo mjeriti i analizirati proteinske i metaboličke markere kroz ciljeve 2 (C2 Otkrivanje biomarkera koristeći proteomsko profiliranje) i 3 (C3 Otkrivanje biomarkera koristeći metabolomsko profiliranje). Kroz ove ciljeve ćemo nastojati: (a) identificirali različito izražene proteinske/metaboličke markere između HT ispitanika i kontrola i ispitati povezanost omics profila s težinom bolesti HT; (b) utvrditi povezanosti između značajnih markera i kliničkih obilježja HT-a; (c) integrirati sve dostupne omics podatke (cjelogenomske genotipove, proteom i metabolom) da bi dobili bolji uvid u manifestaciju same bolesti; (d) ispitati postojanje uzročnih povezanosti između značajnih markera (metabolita i proteina) i HT-a koristeći metodu Mendelove randomizacije. Kroz posljednji cilj 4 (C4 Istraživanje uloge crijevne propusnosti s HT-om) planiramo mjerenje i analiziranje proteina zonulina  koji je trenutno jedini mjerljivi marker crijevne propusnosti. Predloženi sveobuhvatni istraživački pristup pridonijet će razumijevanju temeljnih bioloških putova povezanih s mehanizmima nastanka HT-a i identifikaciji biomarkera koji mogu služiti pri stvaranju prediktivnih modela za rizik od HT-a te do razvoja novih terapijskih, prevencijskih i dijagnostičkih metoda.]]></summary_hr><summary_en><![CDATA[Hashimoto&#39;s thyroiditis (HT) is the most common autoimmune disease today. The molecular mechanisms underlying the disease are still not sufficiently known, therefore this project is aimed at discovering new knowledge related to the molecular and biological pathways related to HT. This project is a continuation of the previous HRZZ Installation Grant, in which we formed the CRO-HT biobank of biological samples and phenotypes for 500 patients with HT and performed a GWAS of this disease. In the meantime, we have collected another 200 control individuals. In the proposed project, through objective 1 (O1 Expansion of the CROHT biobank), we plan to include an additional 200 subjects with HT and to genotype their genome. Also, we plan to measure and analyze protein and metabolic markers through objectives 2 (O2 Proteomic profiling of HT for biomarker discovery) and 3 (O3 Metabolomic profiling of HT for biomarker discovery). Through these objectives, we will try to: a) Identify differentially expressed proteome/metabolome biomarkers between HT cases and controls  and examine omics profiles with HT disease severity, (b) Assess associations between significant biomarkers and clinical features of HT, (c) Integrate all available omics data (genome wide genotypes, proteome and metabolome) to gain deeper insights in disease manifestation, (d) Examine causal relationships between significant biomarkers (metabolites and proteins) and HT using Mendelian randomization. Through the last objective 4 (O4 Evaluation of the role of intestinal wall permeability with HT) we plan to measure and analyse the protein zonulin, which is currently the only measurable marker of intestinal wall permeability. With the proposed comprehensive research, we strive to produce broader knowledge on molecular pathophysiology, diseases biomarkers, predictive models and potential therapeutics to accelerate the implementation of personalised medicine in clinical practice.]]></summary_en></project><project>
<id>15381</id><title_hr><![CDATA[Razvoj hiperheuristika za relokaciju kontejnera]]></title_hr><title_en><![CDATA[Hyper-Heuristic Design for Container Relocation]]></title_en><user_id>24153</user_id><user_firstLast_name>Marko Đurasević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-5398</code><acronim><![CDATA[HHDCR]]></acronim><duration>31.12.2023 - 30.12.2027</duration><status>U tijeku</status><financ_value>140.728,11 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>25593, 26109, 26096, 6984, 866450, 27996, </team_members_id><team_members_names><![CDATA[Nikolina Frid, Mateja Đumić, Rebeka Čorić, Domagoj Jakobović, Francisco Javier Gil Gala, Kristijan Bartol, ]]></team_members_names><keywords_hr><![CDATA[problem relokacije kontejnera, genetičko programiranje, hiperheuristike, evolucijski algoritmi, optimizacija, ]]></keywords_hr><keywords_en><![CDATA[container relocation problem, genetic programming, hyper-heuristics, evolutionary algorithms, optimisation]]></keywords_en><summary_hr><![CDATA[Problem relokacije kontejnera važan je problem iz stvarnog svijeta s primjenom u morskim lukama i skladištima. Budući da se većina svjetske trgovine odvija putem kontejnerskih pošiljaka, optimizacija logističkog procesa u kontejnerskim terminalima od iznimne je važnosti kako za smanjenje troškova, tako i za smanjenje utjecaja na okoliš. Problem se odnosi na dohvaćanje kontejnera pomoću dizalice određenim redoslijedom. Kontejneri se pohranjuju u hrpe, pa se stoga za preuzimanje kontejnera dizalicom on treba nalaziti na vrhu svoje hrpe. To se postiže premještanjem kontejnera koji se nalaze iznad njega na druge hrpe. Cilj problema je smanjiti broj premještanja, jer ona predstavljaju suvišne operacije koje samo povećavaju vrijeme rada i troškove. Jedan od načina rješavanja ovog problema je korištenjem pravila premještanja, jednostavnih konstruktivnih heuristika koja određuje koji kontejner treba premjestiti na koju hrpu. Međutim, osmišljavanje visokokvalitetnih pravila premještanja je naporan zadatak, pogotovo jer su problemski specifična i moraju biti dizajnirana za svaku varijantu problema zasebno.Iz tog razloga, svrha ovog projekta je istražiti primjenu hiperheurističkih metoda za automatsko projektiranje pravila premještanja za problem relokacije kontejnera. Nadalje, cilj projekta je također istražiti metode koje se mogu koristiti za povećanje performansi automatski generiranih pravila premještanja, kako bi se smanjio jaz u performansama između njih i sofisticiranijih metoda, ali i će se istražiti i metode za povećanje njihove interpretabilnosti. Konačno, projekt će također razmotriti primjenu predložene hiperheuristike za različite tipove problema relokacije kontejnera motiviranih primjerima iz stvarnog svijeta, kao što su dinamički problemi, problemi s više kriterija, kao i problemi koji se susreću u industriji proizvodnje čelika.]]></summary_hr><summary_en><![CDATA[The container relocation problem is an important real-world problem with application in maritime yards and warehouses. Due to most of the world trade being conducted through container shipments, optimising the logistic process in container terminals is of utmost importance both to reduce the cost but also the effect on the environment. The problem is concerned with the retrieval of containers by a crane in a certain order. The containers are stored in stacks, and therefore to retrieve the container with the crane it needs to be located at the top of its stack. This is achieved by relocating the containers on top of it to other stacks. The objective of the problem is to reduce the number of relocations, as those represent redundant operations which only increase the operation time and cost. One way of solving this problem is by utilising relocation rules, simple constructive heuristics that determine which container needs to be relocated where. However, designing high quality relocation rules is an arduous task, especially as they are problem specific and have to be designed for each problem variant separately. For that reason, the purpose of this project is to investigate the application of hyper-heuristic methods to automatically design relocation rules for the container relocation problem. Furthermore, the goal of the project is also to investigate methods that can be used to increase the performance of the automatically generated relocation rules, to decrease the gap in the performance between them and more sophisticated methods, but also to increase their interpretability. Finally, the project will also consider the application of the proposed hyper-heuristic for various container relocation problem types motivated by real world examples, such as dynamic problems, multi-objective problems, and also problems found in the steelmaking industry. ]]></summary_en></project><project>
<id>15383</id><title_hr><![CDATA[Geometrijska svojstva i teorija potencijala slučajnih procesa]]></title_hr><title_en><![CDATA[Geometric properties and potential theory of stochastic processes]]></title_en><user_id>987</user_id><user_firstLast_name>Nikola Sandrić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-2277</code><acronim><![CDATA[GPPTSP]]></acronim><duration>31.12.2023 - 30.12.2027</duration><status>U tijeku</status><financ_value>67.183,60 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>790, 865532, 865534, 19109, 145, 635, 23258, 22576, 22575, 19068, </team_members_id><team_members_names><![CDATA[Bojan Basrak, Daniela Ivanković, Tomislav Kralj, Hrvoje Planinić, Zoran Vondraček, Vanja Wagner, Ivan Biočić, Petra Lazić, Ivana Valentić, Stjepan Šebek, ]]></team_members_names><keywords_hr><![CDATA[konveksne ljuske, Dirichletove forme, točkovni procesi, McKean-Vlasovljevi SDJ-ovi, Wright-Fisherove difuzije]]></keywords_hr><keywords_en><![CDATA[convex hulls, Dirichlet forms, point processes, McKean-Vlasov SDEs, Wright-Fisher diffusions]]></keywords_en><summary_hr><![CDATA[Mnogi fenomeni koji se pojavljuju u stvarnom životu i znanosti evoluiraju nasumično u vremenu. Stohastički procesi modeliraju dinamiku takvih nasumičnih evolucija. Razumijevanje svojstava takvih modela omogućuje nam predviđanje budućeg ponašanja slučajnog fenomena koji proučavamo. Cilj ovog projekta je proučavanje određenih klasa stohastičkih procesa, njihovih geometrijskih svojstava i teorije potencijala. Konkretno, naši ciljevi su istražiti sljedeće probleme: i. Granični teoremi za konveksne ljuske slučajnih šetnji i Brownovih gibanjaii. Teorija potencijala i analiza jezgre skokova degenerirane na graniciiii. Granični teoremi i uloga klasteriranja za ekstreme slučajnih procesa i poljaiv. Analiza i asimptotsko ponašanje McKean-Vlasovljevih SDJ-ova i Wright-Fisherovih difuzija.U prvom problemu, usredotočujemo se na klasična statistička svojstva (JZVB, CGT i asimptotiku srednjih vrijednosti i varijanci) intrinzičnih volumena konveksnih ljuski razapetih s trajektorijama više višedimenzionalnih slučajnih šetnji i Brownovih gibanja.Istraživanje u okviru drugog problema usredotočeno je na teoriju potencijala te analizu procesa i integro-diferencijalnih jednadžbi danih odgovarajućim operatorima povezanih s jezgrom skokova koja je degenerirana na granici.U trećem problemu proučavat ćemo probleme izravno ili neizravno povezane s modelima u stohastičkoj geometriji gdje se ekstremi pojavljuju u klasterima (grupama). Nadalje, analizirat ćemo ponašanje repa za maksimum slučajne šetnje s klasterima pod takozvanim Cramerovim uvjetom.U četvrtom problemu proučavamo asimptotska svojstva McKean-Vlasovljevih SDJ-ova, fokusirajući se na subgeometrijsku ergodičnost, te raspravljamo o vezama između difuzija na sferi i Wright-Fisherovih difuzija.Metode istraživanja koje koristimo proizlaze iz teorije vjerojatnosti, teorije slučajnih procesa, teorije potencijala, matematičke analize te konveksne i diferencijalne geometrije.]]></summary_hr><summary_en><![CDATA[Many phenomena arising in real life and science evolve randomly in time. Stochastic processes model the dynamics of such random evolutions. Understanding of properties of these models allows us to predict the future behaviour of the random phenomenon we are studying. The aim of this project is to study certain classes of stochastic processes, their geometric properties and potential theory. Specifically, our objectives are to investigate the following problems:i. Limit theorems for convex hulls of random walks and Brownian motionsii. Potential theory and analysis of jump kernels degenerate at the boundaryiii. Limit theorems and role of clustering for extremes of stochastic processes and fieldsiv. Analysis and asymptotics of McKean-Vlasov SDEs and Wright-Fisher diffusions.In the first problem, we focus on the classical statistical properties (SLLN, CLT, and asymptotics of means and variances) of intrinsic volumes of convex hulls spanned by trajectories of multidimensional multiple random walks and Brownian motions. The research within the second problem is centred around potential theory and analysis of processes and integro-differential equations given by the corresponding operators associated with jump kernels degenerate at the boundary.In the third problem, we will study problems directly or indirectly related with models in stochastic geometry where extremes exhibit clustering. Moreover, we will analyse the tail behaviour for the maximum of a random walk with clusters under the so-called Cramer&#39;s condition.In the fourth problem, we study asymptotic properties of McKean-Vlasov SDEs, focusing on subgeometric ergodicity, and discuss the connections between diffusion processes on sphere and Wright-Fisher diffusions.The research methods we use come from probability theory, theory of stochastic processes, potential theory, mathematical analysis, convex and differential geometry.]]></summary_en></project><project>
<id>15386</id><title_hr><![CDATA[Transformacija postindustrijskog grada: prostor, zajednica i rad]]></title_hr><title_en><![CDATA[The Transformation of the Postindustrial City: Space, Community, and Work]]></title_en><user_id>4785</user_id><user_firstLast_name>Nevena Škrbić Alempijević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-2473</code><acronim><![CDATA[PostCity]]></acronim><duration>20.12.2023 - 19.12.2027</duration><status>U tijeku</status><financ_value>74.319,98 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Etnologija i antropologija, </scie_field_hr><scie_field_en>Ethnology and anthropology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>11206, 27442, 4712, 23640, 29250, 2548, 872973, </team_members_id><team_members_names><![CDATA[Sanja Potkonjak, Tihana Petrović Leš, Petra Kelemen, Kristina Vugdelija, Iva Grubiša, Martina Jakovčić, Lea Biličić, ]]></team_members_names><keywords_hr><![CDATA[postindustrijski grad, prostor, zajednica, rad, kulturna antropologija, etnografska istraživanja]]></keywords_hr><keywords_en><![CDATA[postindustrial city, space, community, work, cultural anthropology, ethnographic research]]></keywords_en><summary_hr><![CDATA[Projekt PostCity istražuje društvenu dinamiku potaknutu suvremenim procesima deindustrijalizacije iz kulturnoantropološke i kulturnogeografske perspektive. Bavi se postindustrijskom svakodnevicom te načinima na koje se različiti društveni akteri nose sa strukturnim promjenama prouzročenima padom industrije i politikama upravljanja nekadašnjim industrijskim prostorima. Analitički se usmjerava na tri sfere transformacija postindustrijskog grada:1. prostor - društvenu proizvodnju i društvenu konstrukciju postindustrijskih lokaliteta2. rad - politike, prakse i iskustva industrijskih i postindustrijskih oblika rada3. zajednice - stanovništvo nekadašnjih industrijskih područja.PostCity stavlja naglasak na razvojni potencijal nekadašnjih industrijskih kompleksa, na novu kulturnu produkciju, ali i na društvene probleme koje izaziva njihova transformacija. Oslanja se na recentna teorijska polazišta postindustrijske i urbane antropologije, antropologije rada, kulturne geografije i humanističkih znanosti o okolišu. Metodološki se temelji na kvalitativnim pristupima i na dubinskom etnografskom istraživanju. Zato je fokus na jednome gradu – Zagrebu. Na potrebu za sustavnim istraživanjem Zagreba upućuje činjenica da je Sveučilište u Zagrebu 2020. postalo dijelom Europskog sveučilišta postindustrijskih gradova UNIC s ciljem suočavanja s izazovima koje nameće deindustrijalizacija.U četverogodišnjem će projektu sudjelovati šest istraživačica s Filozofskog fakulteta Sveučilišta u Zagrebu, jedna suradnica s Prirodoslovno-matematičkog fakulteta Sveučilišta u Zagrebu i doktorand. Projekt će doprinijeti razvoju stručne ekspertize u području postindustrijske antropologije u Hrvatskoj, kao i znanstveno utemeljenom razumijevanju transformacija postindustrijskog grada kao pitanja od javnog interesa.]]></summary_hr><summary_en><![CDATA[The PostCity project will explore the social dynamics triggered by contemporary processes of deindustrialization from the perspectives of cultural anthropology and cultural geography. It deals with everyday life in a postindustrial city and with the ways in which diverse social agents cope with the structural changes induced by industrial decline and current policies of managing former industrial areas. It relies on three analytical axes and modes of transformation:1. space – the social production and social construction of postindustrial localities,2. work – the policies, practices, and experiences of industrial and postindustrial forms of work,3. communities – the inhabitants of former industrial areas.PostCity emphasises the developmental potential of former industrial complexes and new cultural production, but also the social problems that emerge from their transformation. It combines current insights and theoretical approaches from postindustrial and urban anthropology, the anthropology of work, imaginative geography, and environmental humanities. Methodologically, it is based on qualitative strategies and in-depth ethnographic research. This is why the project focuses on only one city – Zagreb. In 2020, the University of Zagreb became part of the UNIC European University of Postindustrial Cities with the aim of facing the societal challenges caused by deindustrialization. Systematic research on these trends is lacking for Zagreb, which is what PostCity intends to provide.This four-year project’s team includes six employees from the Faculty of Humanities and Social Sciences at the University of Zagreb, one researcher from the Faculty of Science at the University of Zagreb, and one Ph.D. student. PostCity will contribute to the development of professional expertise in the field of postindustrial anthropology in Croatia, as well as to a knowledge-based understanding of transformations in postindustrial cities as a matter of public interest.]]></summary_en></project><project>
<id>15387</id><title_hr><![CDATA[Umjetna inteligencija, autonomija i pravednost]]></title_hr><title_en><![CDATA[Artificial Intelligence, Autonomy and Justice]]></title_en><user_id>29263</user_id><user_firstLast_name>Tomislav Bracanović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-1130</code><acronim><![CDATA[AIAJ]]></acronim><duration>31.12.2023 - 30.12.2027</duration><status>U tijeku</status><financ_value>100.682,76 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filozofija, </scie_field_hr><scie_field_en>Philosophy, </scie_field_en><institution_hr><![CDATA[Institut za filozofiju]]></institution_hr><institution_en><![CDATA[Institute for Philosophy in Zagreb]]></institution_en><team_members_id>2690, 6925, 861686, 25046, 22529, 872469, 872999, </team_members_id><team_members_names><![CDATA[Tvrtko Jolić, Ksenija Grubisic, Viktor Ivanković, Karolina Kudlek, Matej Sušnik, Marco Tassella, Helena Drmić, ]]></team_members_names><keywords_hr><![CDATA[Umjetna inteligencija, etika, politička filozofija, autonomija, pravednost]]></keywords_hr><keywords_en><![CDATA[Artificial intelligence, ethics, political philosophy, autonomy, justice]]></keywords_en><summary_hr><![CDATA[Projektni prijedlog posvećen je istraživanju moralnih i političkih implikacija umjetne inteligencije (UI) za vrijednosti autonomije i pravednosti na individualnoj, društvenoj i političkoj razini ljudskog života. U središtu prijedloga je UI usmjerena na praktična tehnološka rješenja koja ima sve šire primjene u raznim vrstama poslovanja, informiranju, komunikaciji, prometu, funkcioniranju javnih i socijalnih službi, svakodnevnom životu, zabavi i osobnim odnosima. Projekt će ispitati normativne izazove koje takvo širenje UI donosi, usredotočujući se na autonomiju i pravednost kao međusobno povezane pojmove etike i političke filozofije. Projekt ima pet ciljeva: istražiti u kojoj su mjeri koncepcije autonomije i pravednosti iz relevantnih teorija etike i političke filozofije oblikovale raspravu o autonomnim vozilima i u kojim smjerovima bi se ta rasprava mogla dalje razvijati; istražiti normativne prijepore povezane s autonomnim naoružanim sustavima, implikacije koje njihova upotreba ima za vrijednosti autonomije i pravednosti te njihovu uklopivost u okvire teorije pravednog rata; istražiti socioekonomske posljedice uvođenja UI u različite poslovne procese, iz perspektive socijalne i distributivne pravednosti i perspektive autonomije različitih dionika tog procesa; istražiti kako sustavi UI generiraju napetost u socijalnim i pravnim kontekstima i koliko je ta napetost, s obzirom na vrijednosti autonomije i pravednosti, specifična u usporedbi s drugim primjenama UI; istražiti narav ljudske nesklonosti sustavima UI i opravdanost behavioralnih utjecaja, neurokemijskih poboljšanja ili umjetne inteligencije za postizanje optimalnog odnosa između njihove učinkovitosti, ljudske autonomije i pravednosti. Projektni prijedlog pristupa autonomiji i pravednosti u njihovoj  povezanosti i istražuje njihov dinamičan odnos kroz različita područja i kontekste primjene UI.]]></summary_hr><summary_en><![CDATA[The project proposal is dedicated to the research of moral and political implications of artificial intelligence (AI) for the values of autonomy and justice at individual, social and political levels of human life. At the heart of the proposal is AI focused on practical technological solutions that have wide applications in various types of business, information, communication, traffic, functioning of public and social services, everyday life, entertainment and personal relationships. The project will examine normative challenges of such a proliferation of AI, focusing on autonomy and justice as interrelated concepts of ethics and political philosophy. The project has five objectives: to investigate to what extent conceptions of autonomy and justice from relevant theories of ethics and political philosophy have shaped the debate on autonomous vehicles and in what directions this debate could develop further; to investigate the normative controversies associated with autonomous weapons systems, the implications their use has for the values of autonomy and justice, and their fit into the framework of just war theory; to investigate the socioeconomic consequences of the introduction of AI into various business processes, from the perspective of social and distributive justice and the perspective of the autonomy of the various stakeholders of that process; to investigate how AI systems generate tension in social and legal contexts and how specific this tension is, with respect to the values of autonomy and justice, compared to other applications of AI; to investigate the nature of human aversion to AI systems and the justifiability of using behavioral influencing, neurochemical enhancement or AI to achieve an optimal relationship between their effectiveness, human autonomy and justice. Project proposal approaches autonomy and justice in their interconnectedness and explores their dynamic relationship across different areas and contexts of the application of AI.]]></summary_en></project><project>
<id>15388</id><title_hr><![CDATA[Nosivi optički kemijski senzori za multimodalno određivanje biomarkera 		 							 							 							]]></title_hr><title_en><![CDATA[Wearable Optical Chemical Sensors for Multimodal Determination of Biomarkers ]]></title_en><user_id>12962</user_id><user_firstLast_name>Ivana Steinberg</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-2595</code><acronim><![CDATA[WearSense]]></acronim><duration>15.12.2023 - 14.12.2027</duration><status>U tijeku</status><financ_value>198.745,77 eur</financ_value><scie_area_hr>Prirodne znanosti, Tehničke znanosti, Interdiciplinarne znanosti, Biotehničke znanosti, Biomedicina i zdravstvo, </scie_area_hr><scie_area_en>Natural sciences, Technological sciences, Interdisciplinary scientific area, Biotechnical sciences, Biomedicine and health sciences, </scie_area_en><scie_field_hr>Kemija, Elektrotehnika, Kemijsko inženjerstvo, Interdisciplinarne tehničke znanosti, </scie_field_hr><scie_field_en>Chemistry, Electrical engineering, Chemical engineering, Interdisciplinary technological sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet kemijskog inženjerstva i tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Chemical Engineering and Technology]]></institution_en><team_members_id>7148, 21443, 865105, 25541, 26087, 26217, 25994, 866105, 869880, 871165, 872906, 874155, </team_members_id><team_members_names><![CDATA[Dubravko Babic, Željka Lučev Vasić, Matija Roglić, Ljiljana Fruk, Ernest Meštrovic, Matthew David Steinberg, Gerhard Mohr, Martina Lihter, Iva Žuvić, Deepak Joshy, Ivana Perković, HUMA YILMAZ, ]]></team_members_names><keywords_hr><![CDATA[kemijski senzor, nosivi senzor, biomarker, ionski senzori, nanomaterijali, pH indikatori, fotopletizmografija]]></keywords_hr><keywords_en><![CDATA[chemical sensor, wearable sensor, biomarker, ion sensing, nanomaterials, pH indicators, photoplethysmography]]></keywords_en><summary_hr><![CDATA[Komercijalni nosivi uređaji (fitness trackers) i pametni satovi za praćenje fizioloških parametara koriste optičku detekciju za određivanje otkucaja srca (HR) i varijabilnosti otkucaja srca (HRV) pomoću fotopletizmografije (PPG). Mogućnost integracije (bio)kemijskog optičkog senzora u takve uređaje za istovremeno mjerenje fizičkih i (bio)kemijskih signala putem iste optičke platforme pruža jedinstvenu priliku za inovativno istraživanje. U projektu ćemo implementirati multimodalno određivanje biomarkera kombinirajući fizičke i biokemijske parametre. Razvit ćemo optičke kemijske senzore i metode ekstrakcije signala te algoritme primjenjive na nosive uređaje sljedeće generacije. U znanstvenim  istraživanjima slabo su zastupljeni nosivi optički senzor za kontinuirano praćenje biomarkera u biofluidima. Naša dosadašnjih istraživanja u području kemijskih optičkih senzora uklapaju se u uočeni nedostatak. Tome pripadaju novih optički senzorski materijali  na bazi ionofora, (nano)optoda i prirodno dobivenih pigmenata. Primjenom racionalog  dizajna za  funkcionalizaciju kemijski osjetljivih sučelja koristit će se nosivi  biokompatibilnih (nano)materijali. Integracijom i laboratorijskom karakterizacijom te evaluacijom na elektroničkoj platformi dobit će se mogućnost praćenja fizičkih  parametara (HR, HRV) i odabranih biokemijskih markera  kontinuirano u realnom vremenu. Glavni istraživački tim je sa Sveučilišta u Zagrebu (FKIT i FER) ojačan suradnicima iz Austrije, Švicarske i UK-a. Projekt će omogućit mladim istraživačima obuku u multidisciplinarnom području primijenjenih istraživanja u visoko konkurentnom području nosivih senzora. Glavni rezultat projekta bit će optički kemijski senzori  za praćenje važnih analita iz znoja i intersticijske tekućine. Istraživanja pokrivaju  globalnu problematiku područja nosivih (bio)kemijskih senzora – brzorastućeg, atraktivnog i vrlo izazovnog područja moderne znanosti i tehnologije. ]]></summary_hr><summary_en><![CDATA[Commercial wearable fitness trackers and smartwatches use optical detection for heart rate (HR) and heart rate variability (HRV) determination using photopletysmography (PPG).This provides a unique opportunity for integration of (bio)chemical optical sensing components and simultaneous measurement of physical and chemical signals via the same optical platform. In this project we intend to implement multimodal biomarker determination combining physical and biochemical parameters. We will develop optical chemical sensors and signal extraction methods and algorithms applicable to next generation wearable devices. There is a gap in current research output and in the availability of wearable optical sensors for continuous monitoring of biofluids. To bridge this gap we will use ionophore based optical sensors,(nano)optodes and naturally derived pigments. We are proposing to use an integrated reiterative development methodology that includes new sensor materials development, fabrication technology, and integration with optics. It will involve rational design and scalable fabrication of chemically sensitive interfaces using wearable biocompatible (nano)materials, and their integration on an electronic platform capable of sensing heartbeat parameters (HR, HRV) and biochemical markers in continuous real-time.The project will bring together a core research team from University of Zagreb (FCET and FEEC) strengthened with collaborators from Austria, Switzerland and the UK. This project environment will provide young researchers  training in a multidisciplinary area of applied research in a highly competitive field.The main result of the project will be functional optical chemical sensors each optimised for the determination of important sweat and interstitial fluid (ISF) analytes. In the course of the research, we will address some of the major challenges and in doing so will make a significant contribution to advancing the state-of-the-art. ]]></summary_en></project><project>
<id>15390</id><title_hr><![CDATA[Analiza stohastičkih procesa na mrežama u sustavima s ograničenom informacijom]]></title_hr><title_en><![CDATA[ Stochastic processes on networks analysis in systems with limited information]]></title_en><user_id>11143</user_id><user_firstLast_name>Vinko Zlatić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-1648</code><acronim><![CDATA[SPONA]]></acronim><duration>18.12.2023 - 17.12.2027</duration><status>U tijeku</status><financ_value>165.346,09 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, Interdisciplinarne prirodne znanosti, </scie_field_hr><scie_field_en>Physics, Interdisciplinary natural sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>3358, 5624, 866320, </team_members_id><team_members_names><![CDATA[Davor Horvatic, Boris Podobnik, Hrvoje Štefančić, ]]></team_members_names><keywords_hr><![CDATA[kompleksni sustavi, kompleksne mreže, stohastički procesi, graf neuralne mreže, master jednadžba]]></keywords_hr><keywords_en><![CDATA[complex systems, complex networks, stochastic processes, graph neural networks, master equation]]></keywords_en><summary_hr><![CDATA[Stohastički procesi na kompleksnim mrežama imaju niz važnih implikacija u stvarnom svijetu. Ipak, iako potpuna informacija o mreži često nije prisutna u slučajevima od interesa, nema značajnijeg napretka koji bi ovu značajku uključio u predviđanje stohastičkih procesa. Kako bismo riješili ovaj problem, u ovom projektu ćemo istražiti kako predvidjeti stohastičku dinamiku na mrežama s nepotpunim informacijama. Za ovaj zadatak dalje ćemo razviti teoriju približnih metoda za predviđanje nekih stohastičkih procesa proširujući postojeće metode kako bi uključile izračunavanje pogrešaka i slučajeve procesa s nebinarnim brojem stanja. Također ćemo razviti duboku neuronsku mrežu za učenje stohastičke dinamike iz podataka s nepotpunim informacijama o strukturi mreže. Ovi će podaci biti osigurani opsežnim simulacijama stohastičkih procesa na klasteru računala. Stohastički procesi koji će se koristiti bit će pažljivo odabrani, a bit će razvijena i posebna shema za uzorkovanje parametara od interesa. Nadalje, usporedit ćemo ta dva smjera istraživanja i identificirati koji pristup bolje funkcionira u kojim slučajevima. Na kraju projekta trebali bismo steći dovoljno znanja da bismo mogli konstruirati alate za predviđanje koji bi se mogli koristiti na stvarnim podacima u stvarnim situacijama.]]></summary_hr><summary_en><![CDATA[Stochastic processes on complex networks have a range of important implications in the real world. Yet, although the complete information of the network is often not present in cases of interest, there is no significant progress that would include this feature in prediction of stochastic processes. To address this issue, in this project, we will investigate how to predict stochastic dynamics on the networks with incomplete information. For this task we will further develop theory of approximate methods to predict some stochastic processes extending the existing methods to include computation of errors and to include cases of processes with non binary number of states. We will also develop a deep neural network to learn stochastic dynamics from the data with incomplete information of the network structure. These Data will be provided through extensive simulations of stochastic processes on computer cluster. Stochastic processes to be used will be carefully chosen and a special scheme to sample parameters of interest will also be developed. Furthermore, we will compare those two research directions and identify which approach works better in which cases. In the end of the project we should acquire enough knowledge to be able to construct prediction tools that could be used on real data in real world situations.]]></summary_en></project><project>
<id>15391</id><title_hr><![CDATA[Skaliranje u stohastičkim modelima]]></title_hr><title_en><![CDATA[Scaling in stochastic models]]></title_en><user_id>305</user_id><user_firstLast_name>Danijel Grahovac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-8081</code><acronim><![CDATA[SCALISM]]></acronim><duration>15.12.2023 - 14.12.2027</duration><status>U tijeku</status><financ_value>176.742,33 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Fakultet primijenjene matematike i informatike]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, School of Applied Mathematics and Informatics]]></institution_en><team_members_id>279, 13501, 4390, 866200, 19296, 869804, 872874, 873356, </team_members_id><team_members_names><![CDATA[Nenad Šuvak, Ivan Papić, Nikolai Leonenko, Alla Sikorskii, Željka Salinger, Magdalena Mikić, Sven Dukić, Aleksandra Petrovic, ]]></team_members_names><keywords_hr><![CDATA[Slučajni procesi, svojstva skaliranja, superpozicije procesa, granični teoremi, difuzije, skaliranje vremena procesa, multifraktalnost, EEG signali]]></keywords_hr><keywords_en><![CDATA[Stochastic processes, scaling properties, superpositions of processes, limit theorems, diffusions, scaling of time, multifractality, EEG signals]]></keywords_en><summary_hr><![CDATA[Stohastički modeli od ključne su važnosti u opisivanju brojnih fenomena u raznim područjima znanosti i života. Bitno svojstvo vremenski ovisnih modela je njihovo ponašanje u odnosu na promjenu vremenske odnosno prostorne skale. Karakteristike brojnih fenomena mogu se značajno mijenjati promjenom skale. Primjerice, u svijetu čestica vladaju potpuno drugačiji prirodni zakoni od onih na astronomskim skalama. Potreba za modelima sa specifičnim svojstvima skaliranja dolazi iz brojnih praktičnih primjena u medicini, biologiji, fizici, financijama, ekonomiji i drugim područjima znanosti. Cilj projekta je konstrukcija i proučavanje stohastičkih modela s posebnim svojstvima skaliranja. Poseban naglasak je na proučavanju svojstva modela na granično malim ili velikim skalama. Između ostalog, ponudit će se objašnjenje fenomena vezanog uz skaliranje empirijskih momenata koji je poznat kao Taylorov zakon. Konstruirat će se i analizirati nove klase slučajnih procesa dobivene zamjenom vremenske skale nekih standardnih procesa. Razvijeni modeli primijenit će se u epidemiologiji i analizi EEG signala te će se razviti model za klasifikaciju neurokognitivnih ishoda na osnovu parametara skaliranja.]]></summary_hr><summary_en><![CDATA[Stochastic models are of great importance in describing numerous phenomena in various fields of science and life. An essential property of time-dependent models is their behavior under time and space scaling. The characteristics of many phenomena can be significantly changed by changing the scale. For example, as we move from the tiny world of particles to the astronomical scales, the laws of nature may behave drastically different. The need for models with specific scaling properties comes from numerous practical applications in medicine, biology, physics, finance, economics and other fields of science. The goal of the project is the construction and investigation of stochastic models with special scaling properties. The emphasis is placed on the study of properties of models in the limits of small or large scales. Among other results, a possible explanation will be provided for the phenomenon related to the scaling of empirical moments, known as Taylor&#39;s law. By replacing the time scale of some standard processes, the new classes of stochastic processes will be constructed and analyzed. These new models will be applied in epidemiology and EEG signal analysis. Furthermore, model for the classification of neurocognitive outcomes based on scaling parameters will be developed.]]></summary_en></project><project>
<id>15392</id><title_hr><![CDATA[Određivanje karakteristika učenika korištenjem edukacijskih robotskih tehnologija]]></title_hr><title_en><![CDATA[Determining students&#39; characteristics using educational robot technologies]]></title_en><user_id>6592</user_id><user_firstLast_name>Ana Sović Kržić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-1915</code><acronim><![CDATA[DESCARTES]]></acronim><duration>15.01.2024 - 14.01.2028</duration><status>U tijeku</status><financ_value>192.965,69 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, Elektrotehnika, Temeljne tehničke znanosti, Interdisciplinarne tehničke znanosti, </scie_field_hr><scie_field_en>Computer sciences, Electrical engineering, Basic engineering sciences, Interdisciplinary technological sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>25376, 3612, 28856, 866335, 866318, 869554, 871273, 871174, 865244, 872927, </team_members_id><team_members_names><![CDATA[Liljana Pushkar, Tomislav Jagušt, Ivana Storjak, Renata Geld, Katarina Faraguna, Ivan Brčić, Petra Livaja Mušac, Jana Alajbeg, Dorotea Potoč, Leon Stjepan Uroić, ]]></team_members_names><keywords_hr><![CDATA[Edukacijski roboti, Kognitivne sposobnosti, model učenika, strojno učenje, značajke, fiziološki signali, karakteristike učenika]]></keywords_hr><keywords_en><![CDATA[Educational robots, cognitive abilities, student model, machine learning, features, physiological signals, students’ characteristics]]></keywords_en><summary_hr><![CDATA[Cilj DESCARTES projekta je pronaći odgovor na pitanje mogu li edukacijski roboti pomoći pri određivanju kognitivnih sposobnosti učenika (npr. pažnje, percepcije, pamćenja, prostorne orijentacije i slično). Edukacijski roboti su svojom formom i funkcionalnošću prilagođeni učenicima – pružaju im poznatu okolinu kao logični nasljednici igračaka, povezuju apstraktno s fizičkim, potiču kreativnost i omogućuju istovremeni rad svih učenika u razredu te su stoga idealno sredstvo za predikciju mjerljivih kognitivnih karakteristika učenika. U okviru projekta će biti dizajnirane radionice s edukacijskim robotskim tehnologijama pomoću kojih će se kod učenika stimulirati kognitivne funkcije od istraživačkog interesa (npr. održavanje i usmjeravanje pažnje, vidno-motoričke sposobnosti, prostorna orijentacija i slično). Podaci s robota i fiziološki signali učenika prikupljeni za vrijeme radionice će se analizirati korištenjem metoda strojnog učenja te će ih se validirati rezultatima standardiziranih testova kognitivnih sposobnosti učenika. Rezultati projekta će biti korisni za odgojno-obrazovne intervencije i nastavnike kako bi bolje razumjeli učenike s kojima rade te kako bi svako pojedino dijete dobilo odgovarajuću potporu ovisno o osobnim potencijalima ili teškoćama.]]></summary_hr><summary_en><![CDATA[The aim of the DESCARTES project is to find an answer to the question of whether educational robots can help determine students&#39; cognitive abilities (e.g., attention, perception, memory, spatial orientation, etc.). Educational robots are suited for students considering their form and functionality - they provide a familiar environment as the logical successors of toys, cohere the abstract with the physical, encourage creativity and enable the simultaneous work of all students in the class, and are therefore an ideal tool for predicting measurable cognitive characteristics of students. Within the project, workshops will be designed using educational robotic technologies, which will aid in stimulating students&#39; cognitive functions of research interest (e.g., maintaining and directing attention, visual-motor skills, spatial orientation, etc.). Data from the robot and students’ physiological signals collected during the workshop will be analyzed using machine learning methods and validated using the standardized tests of students&#39; cognitive abilities. The results of the project will benefit educational interventions and teachers by advancing the understanding of their students and providing an opportunity that each individual child receives appropriate support depending on personal potentials or difficulties.]]></summary_en></project><project>
<id>15400</id><title_hr><![CDATA[Primjena održivih principa ekstrakcije i formulacije u razvoju nutraceutika iz otpada rajčice]]></title_hr><title_en><![CDATA[Application of sustainable extraction and formulation principles in development of tomato waste-derived nutraceuticals]]></title_en><user_id>3927</user_id><user_firstLast_name>Dubravka Vitali Čepo</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-4597</code><acronim><![CDATA[ExtracTom-App]]></acronim><duration>20.12.2023 - 19.12.2027</duration><status>U tijeku</status><financ_value>180.237,58 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo, Biotehničke znanosti, </scie_area_hr><scie_area_en>Biomedicine and health sciences, Biotechnical sciences, </scie_area_en><scie_field_hr>Farmacija, Interdisciplinarne biotehničke znanosti, </scie_field_hr><scie_field_en>Pharmaceutical sciences, Interdisciplinary biotechnical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Farmaceutsko-biokemijski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Pharmacy and Biochemistry]]></institution_en><team_members_id>21380, 6966, 6660, 22753, 1258, 858452, 24926, 866405, 26256, 869825, 858412, </team_members_id><team_members_names><![CDATA[Kristina Radić, Lovorka Vujić, Ana-Marija Domijan, Jasna Jablan, Tomislav Vinković, Ivan Mamić, Laura Nižić Nodilo, Nada Šmigić, Emerik Galić, Tea Petković, Ana Mandura, ]]></team_members_names><keywords_hr><![CDATA[otpad rajčice, zelena ekstrakcija, nutraceutici, karotenoidi, pektin, nanoselen, ciklodekstrini, mehanokemijska kompleksacija, ekološki otisak]]></keywords_hr><keywords_en><![CDATA[tomato waste, green extraction, nutraceuticals, carotenoids, pectin, nanoselenium, cycldextrins, mechanochemical complexation, ecological footprint]]></keywords_en><summary_hr><![CDATA[Otpad koji zaostaje nakon proizvodnje hrane predstavlja velik ekonomski gubitak i opterećenje za okoliš, ali i neiskorišten izvor fitokemikalija s velikim potencijalom primjene. ExtracTom-App je usmjeren na razvoj održive formulacije inovativnih nutraceutika korištenjem otpada rajčice (OR) kao dostupne sekundarne sirovine bogate funkcionalnim sastavnicama (pektinima i karotenoidima). Usklađen je s globalnim smjernicama za prijelaz na resursno učinkovitu proizvodnju te valorizaciju tokova otpada. U okviru projekta razvit će se zeleni postupci ekstrakcije pektina (P) i karotenoida (K) korištenjem neistraženog pristupa kombinirane mehanokemijske i mikrovalne ekstrakcije (MKE/MAE), zelenih tehnika visoke razine tehnološke spremnosti (mogućnost scale-up-a). P i K će se koristiti u razvoju inovativnih formulacija nutraceutika (nanočestica selena stabiliziranih s P i inkluzijskih kompleksa K), a s ciljem poboljšanja stabilnosti, bioraspoloživosti, biokompatibilnosti i biološke aktivnosti (antimikrobnog, antioksidativnog i protuupalnog djelovanja). Pri tome će se istražiti mogućnosti zelenih formulacijskih pristupa - biogene sinteze odnosno mehanokemijske kompleksacije. Analiza životnih ciklusa (LCA), kao znanstveno utemeljena metodologija, biti će korištena za provođenje LCA rajčice te određivanje ekološkog otiska novorazvijenih ekstrakcijskih/formulacijskih procesa. Rezultati projekta pružit će nova saznanja o mogućnostima MKE/MAE u ekstrakciji bioaktivnih komponenata; potencijalu i ograničenjima zelenih formulacijskih postupaka te implementacije LCA u područje razvoja nutraceutika. U širem smislu rezultati projekta ponuditi će konkretna formulacijska rješenja koja se mogu prilagoditi širem spektru biološki aktivnih spojeva niske stabilnosti/bioraspoloživosti ili uske terapijske širine. Razvojem održivih procesa i identificiranjem obnovljivih sirovina koje nisu u konkurenciji s drugim proizvodnim lancima  doprinijeti će poboljšanju održivosti sustava proizvodnje hrane]]></summary_hr><summary_en><![CDATA[The waste remaining after food production represents economic loss and environmental burden but also an underused source of bioactive components (BCs). ExtracTom-App is focused on developing sustainable processes for the formulation of innovative nutraceuticals using tomato waste (TW) as an available secondary raw material rich in BCs – pectin (P) and carotenoids (C)). It complies with global guidelines for the transition to resource-efficient production. Within the project green extraction procedures for P and C will be developed, using an unexplored combined mechanochemical and microwave extraction (MCE/MAE) - green extraction techniques with satisfactory level of technological readiness. P and C will be utilized in the development of innovative formulations (Se nanoparticles coated with P and inclusion complexes of C), with the aim of improving their stability, bioavailability, biocompatibility, and biological activity (antimicrobial, antioxidant, and anti-inflammatory). Novel green forrmulation approaches will be explored - biogenic synthesis and mechanochemical complexation. Life cycle analysis (LCA), as a scientifically based methodology, will be used to investigate life cycle of tomatoes and the ecological footprint of the newly developed extraction/formulation processes. The results of the project will provide new knowledge about combined MCE/MAE in green extraction of BCs; the potential and limitations of green formulation approaches; and the implementation of LCA in the field of nutraceuticals. In a broader sense, formulation solutions obtained within the project can be adapted to a wider range of biologically active compounds with low stability/bioavailability or narrow therapeutic range. By developing sustainable processes and identifying renewable raw materials that are not in competition with other production chains, it will contribute to the improved sustainability of food production systems.]]></summary_en></project><project>
<id>15404</id><title_hr><![CDATA[Iz rata u mir: hrvatski branitelji u tranziciji]]></title_hr><title_en><![CDATA[From War to Peace: Croatian War Veterans in Transition]]></title_en><user_id>7870</user_id><user_firstLast_name>Aleksandar Jakir</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-8510</code><acronim><![CDATA[CRO VETERANS]]></acronim><duration>18.12.2023 - 17.12.2027</duration><status>U tijeku</status><financ_value>80.795,58 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Povijest, Interdisciplinarne humanističke znanosti, </scie_field_hr><scie_field_en>History, Interdisciplinary humanities, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>28961, 866244, 866240, 866269, 7843, 866228, 871411, </team_members_id><team_members_names><![CDATA[Andrijana Perković Paloš, Julija Barunčić Pletikosić, Ivan Radoš, Ante Jureta, Tihomir Cipek, Tomislav Šulj, Luka Šajnović, ]]></team_members_names><keywords_hr><![CDATA[branitelji, Domovinski rat, tranzicija, prilagodba mirnodopskom životu, uloga u društvu]]></keywords_hr><keywords_en><![CDATA[veterans, Homeland War, transition, adjustment to life under conditions of peace, role in society]]></keywords_en><summary_hr><![CDATA[U brojnim suvremenim historiografijama fenomen „veterana“, u značenju isluženih vojnika odnosno ratnika ili boraca prošlih ratova, i njihova uloga u različitim društveno-povijesnim procesima, predmet je znanstvenog interesa i mnogobrojnih istraživanja.  Ako ćemo se samo fokusirati na istraživanja koji se bave ulogom veterana u 20. stoljeću, nastanak „masovne, transnacionalne kohorte muškaraca povezanih činjenicom da su svi služili kao vojnici tijekom rata“ prepoznato je kao jedna od najvažnijih baština rata. U današnjoj se Republici Hrvatskoj Domovinski rat, u kojem je izborena samostalnost i postignuta teritorijalna cjelovitost, smatra jednim od temeljnih identitetskih odrednica suvremene hrvatske države pa je stoga očekivano jedna od najzastupljenijih i u historiografskom istraživanju suvremene hrvatske povijesti. Međutim, u fokusu brojnih znanstvenih radova i monografija uglavnom su njeni politički i vojni aspekti, dok mnogi aspekti društvene povijesti suvremene Hrvatske, uvelike obilježene ratom i posljedicama koje je izazvao, dosad nisu bili predmetom sustavnijeg znanstvenog istraživanja. Hrvatska je jedna od rijetkih zemalja u Europi koja se morala suočiti s izazovima i poteškoćama procesa tranzicije i prilagodbe veterana s ratnog u mirnodopske uvjete na samom kraju 20. stoljeća i to usporedno s velikim ljudskim gubicima i materijalnom štetom. Braniteljska populacija dosad je bila predmetom znanstvenog istraživanja u politologiji, sociologiji, medicini, psihologiji, ali ne i u historiografiji.  Ne postoji nijedan pokušaj sustavnog povijesnog prikaza prijelaza branitelja s ratnog na mirnodopsko stanje i njihove prilagodbe novim uvjetima u neposrednom poslijeratnom razdoblju, a u kontekstu društvene povijesti kao znanstvene discipline koja istražuje društvene i kulturne aspekte povijesnih razdoblja i promjena. ]]></summary_hr><summary_en><![CDATA[The phenomenon of “veterans” and their role in different social-historical processes, has been the topic of scientific interest and much research in contemporary historiography.  If we just focus on research that deals with role of the 20th century veterans, the origin “of a mass, transnational cohort of men bound by the fact that they had all served as soldiers during the war” is recognized as “one of the most significant legacies of war.”  This is also the case with Croatia which won its independence and achieved its territorial integrity in the War of Independence, which is considered one of the foundations of the Republic of Croatia and its national identity. However, the vast majority of research articles and monographs focuses mainly on its political and military aspects, whereas numerous segments of social history, significantly marked by the War and its consequences, have not been systematically researched as of yet. In the immediate post-war period in the second half of the 1990s, along with the reconstruction of the country and the return of displaced persons and refugees to their homes, former soldiers, Croatian “defenders,” began their adjustment to peaceful conditions. They are also considered one of the foundations of the contemporary Croatian state. Croatia was one of the few European countries that had to face the challenges and difficulties of transition as well as the veterans’ adjustment from war to peace and the great losses of human life and the damage the war caused at the very end of the 20th century. Our aim is to systematically research the Croatian veterans’ transition, i.e., their adjustment to the new conditions of the immediate post-war period in the context of social history as a discipline that aims to research different social and cultural aspects and changes in different historical periods.]]></summary_en></project><project>
<id>15405</id><title_hr><![CDATA[Homogenizacija i optimizacija u mehanici čvrstih tijela]]></title_hr><title_en><![CDATA[Homogenization and Optimization in Mechanics of Solids]]></title_en><user_id>349</user_id><user_firstLast_name>Krešimir Burazin</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-5181</code><acronim><![CDATA[HOMeoS]]></acronim><duration>23.12.2023 - 22.12.2027</duration><status>U tijeku</status><financ_value>176.653,63 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Fakultet primijenjene matematike i informatike]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, School of Applied Mathematics and Informatics]]></institution_en><team_members_id>866238, 23610, 866249, 20370, 23626, 23775, 23783, 6764, 23191, 869808, 871170, </team_members_id><team_members_names><![CDATA[Matteo Capoferri, Paolo Piovano, Sergio Gutierrez, Marin Bužančić, Mikhail Cherdantsev, Ivana Crnjac, Jelena Jankov, Igor Velčić, Josip Žubrinić, Ivan Vuković, Maja Jolić, ]]></team_members_names><keywords_hr><![CDATA[homogenizacija, redukcija dimenzije, optimalni dizajn, elastičnost, Friedrichsovi sustavi, varijacijski račun, H-konvergencija, Gama-konvergencija]]></keywords_hr><keywords_en><![CDATA[homogenization, dimension reduction, optimal design, elasticity, Friedrich&#39;s systems, calculus of variations, H-convergence, Gamma-convergence]]></keywords_en><summary_hr><![CDATA[Glavne teme ovog projekta jesu različiti problemi homogenizacije, redukcija dimenzije i strukturne optimizacije s posebnim naglaskom na primjene u mehanici krutih tijela. Fizikalna ideja homogenizacije, tj. usrednjenja visoko heterogenog medija kako bi se izvela njegova efektivna svojstva, ima prilično dugu povijest. Matematički, proizašla je iz poteškoća s kojima se suočava (numerička) analiza odgovarajućih parcijalnih diferencijalnih jednadžbi u slučajevima kada materijal oscilira na maloj skali ili je znatno tanji u jednom ili dva smjera. Prijelaz na limes (s obzirom na neke parametre materijala, tj. u odgovarajućoj topologiji) obično dovodi do modela za koje se očekuje da budu jednostavniji, kako s analitičkog tako i s numeričkog stajališta. Uz pretpostavku da je priroda oscilacija materijala ergodička , periodična ili potpuno općenita, pripadna zadaća može se tretirati metodom (stohastičke) dvoskalne konvergencije, pristupom preko kompaktnosti kompenzacijom (H-konvergencija, H-mjere) ili tehnikama varijacijskog računa (Gama-konvergencija).Opisani postupak prikladan je za modeliranje kompozitnih materijala, koji su fine mješavine dvaju ili više sastavnih materijala. Poseban interes javlja se za visokokontrastne kompozite, gdje se dobiva metamaterijal sa strukturom „band gap“ spektra. Optimiziranje dizajna uređaja izrađenih od takvog responzivnog materijala i strukturalnog materijala od velikog je interesa.Istraživanje predloženo projektom obuhvaća modeliranje takvih materijala i sastoji se od izazovnih i suvremenih problema, što uključuje teme poput stohastičke homogenizacije visokokontrastnih medija, homogenizacije i redukcije dimenzije u elastoplastičnosti, kristalizacije, kvantitativne homogenizacije  za evolucijiu za tanke linearne elastične strukture, homogenizacije Kirchhoff-Love i Reissner-Mindlinove jednadžbe ploče, strukturalne optimizacije tankih elastičnih ploča i u 3D lineariziranoj elastičnosti, te homogenizacije Friedrichsovih sustava.]]></summary_hr><summary_en><![CDATA[The main topics of this project are different problems in homogenization, dimension reduction and structural optimization with the special emphasis on the applications in mechanics of solids. The physical idea of homogenization, i.e., averaging a highly heterogeneous media to derive its effective properties has a rather long history. Mathematically, it emerged from difficulties faced with (numerical) analysis of governing partial differential equations in cases when the material oscillates on a small scale or is significantly thinner in one or two directions. A passage to the limit (with respect to some material parameters, i.e., in appropriate topology) usually leads to models that are expected to be simpler, both from the analytical and numerical point of view. The nature of the oscillations of the material can be assumed to be ergodic, periodic or completely general and thus analysed by (stochastic) two-scale convergence method, compensated compactness approach (H-convergence, H-measures ) or calculus of variations techniques (Gamma-convergence). Described procedure is well suited for modelling of composite materials, which are fine mixtures of two or more constituent materials. The special interest arises in high-contrast composites, where one obtains a metamaterial with a band gap structure of the spectrum. Optimizing design of devices made of such responsive material and structural material is of great interest. The research proposed by the project encompasses modelling of such materials, and constitutes of challenging and contemporary problems, including topics of stochastic homogenization of high-contrast media, homogenization and dimension reduction in elasto-plasticity, crystallization, quantitative homogenization for evolution for linear elastic thin structures, homogenization of Kirchhoff-Love and Reissner-Mindlin plate equations, structural optimization of thin elastic plates and in 3D linearized elasticity, homogenization of Friedrichs’ systems.]]></summary_en></project><project>
<id>15411</id><title_hr><![CDATA[Klimatsko modeliranje na konvektivnoj skali za područje Hrvatske: ekstremi oborine i razine mora]]></title_hr><title_en><![CDATA[Convective-scale climate modelling for Croatia: Precipitation and ocean-level extremes]]></title_en><user_id>21139</user_id><user_firstLast_name>Danijel Belušić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-9139</code><acronim><![CDATA[C3PO]]></acronim><duration>31.12.2023 - 30.12.2027</duration><status>U tijeku</status><financ_value>184.511,25 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Geofizika, </scie_field_hr><scie_field_en>Geophysics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>11142, 3146, 25087, 18910, 1265, 866267, 195, 862794, 868163, 861747, 25094, 873044, </team_members_id><team_members_names><![CDATA[Maja  Telišman Prtenjak, Lidija Srnec, Sarah Ivušić, Kristian Horvath, Ivan Guettler, Endi Keresturi, Ivica Vilibić, Clea Denamiel, Patrik Jureša, Branimir Omazić, Sara Ivasić, Marin Belamarić, ]]></team_members_names><keywords_hr><![CDATA[modeli konvektivne skale, simulacije događaja na visokoj rezoluciji, klimatski ekstremi, ekstremna oborina, obalno poplavljivanje]]></keywords_hr><keywords_en><![CDATA[Convection permitting models, event-based downscaling, climate extremes, extreme precipitation, coastal flooding]]></keywords_en><summary_hr><![CDATA[Klimatski i vremenski ekstremi postaju sve jači i učestaliji u mnogim regijama kao posljedica globalnih klimatskih promjena. Jedini dostupni alati za procjenu budućih promjena ekstrema su klimatski modeli. Iako najsuvremeniji klimatski modeli mogu reproducirati neke od ekstrema, postoji velika skupina događaja koji se ne mogu ispravno simulirati, kao što su ekstremne oborine ili lokalne oluje. Ovaj projekt koristi novu generaciju klimatskih modela, koji se nazivaju modeli dopuštanja konvekcije, kako bi se značajno poboljšala reprodukcija ekstrema, s posebnom dodanom vrijednošću za ekstremne oborine i lokalne događaje kao što su urbani toplinski valovi i planinski vjetrovi. Ovi se modeli sve više koriste u istraživanju i primjeni jer je ovo prvi put da klimatski modeli mogu dati realnu procjenu budućih promjena ekstremnih oborina. Međutim, ovi modeli zahtijevaju previše računalnih resursa da bi se koristili kao alati za pružanje klimatskih informacija korisnicima i dionicima. To je zato što je važna komponenta informacija o klimatskim promjenama procjena nesigurnosti, koja zahtijeva veliki skup pojedinačnih simulacija. U ovom projektu nudimo zaobilaženje ove prepreke razvijanjem metodologije za klimatske simulacije samo specifičnih kratkotrajnih ekstremnih događaja, što može smanjiti računalne troškove za oko 50 puta i tako osloboditi dovoljno resursa za ispravnu procjenu nesigurnosti. Kao rezultat toga, ovaj projekt (i) uvodi novu generaciju klimatskih modela kao zajednički alat za hrvatska klimatska istraživanja i primjene, (ii) kombinira akademske, operativne i korisnički orijentirane aktivnosti u zajednički i međunarodno konkurentan okvir, i (iii) nudi inovativna i općenita rješenja za primjene ovih modela u studijama procjene utjecaja i rizika za različite dionike kao što su urbanisti i upravna tijela.]]></summary_hr><summary_en><![CDATA[Climate and weather extremes are increasing in strength and frequency in many regions following the global climate change. The only available tools for assessing future changes of extremes are climate models. While the state-of-the-art climate models can reproduce some of the extremes, there is a large group of events that cannot be properly simulated, such as extreme precipitation or local windstorms. This project uses the new generation of climate models, called convection permitting models, to make a step improvement in reproducing extremes, with particular added value for extreme precipitation and local events such as urban heat waves and mountain wind systems. These models are being increasingly used in research and applications because this is the first time that climate models can give realistic assessment of future changes of extreme precipitation. However, these models are prohibitively computationally expensive to be used as tools for offering proper climate information to users and stakeholders. This is because an important component of climate change information is an estimation of uncertainty, which requires a large ensemble of individual simulations. In this project we offer to circumvent this hurdle by developing a methodology for climate simulations of only specific short-lived extreme events, which can decrease the computational cost by about 50 times and thus release enough resources for proper uncertainty estimate. As a result, this project (i) introduces the new generation of climate models as a common tool for the Croatian climate research and applications, (ii) combines academic, operational and user-oriented activities into a common and internationally-competitive framework, and (iii) offers innovative and general solutions for user-tailored applications of these models in impact and risk assessment studies for various stakeholders such as urban developers and policy makers.]]></summary_en></project><project>
<id>15412</id><title_hr><![CDATA[Održivi pristup u razvoju jestivih prevlaka u povećanju trajnosti svježe jadranske ribe]]></title_hr><title_en><![CDATA[Sustainable concept in ACTive edible COatings development for shelf-life extension of fresh Adriatic FISH]]></title_en><user_id>19976</user_id><user_firstLast_name>Mia Kurek</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-1837</code><acronim><![CDATA[ActCoFISH]]></acronim><duration>29.12.2023 - 28.12.2027</duration><status>U tijeku</status><financ_value>199.084,23 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Prehrambena tehnologija, Interdisciplinarne biotehničke znanosti, </scie_field_hr><scie_field_en>Food technology, Interdisciplinary biotechnical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Food Technology and Biotechnology]]></institution_en><team_members_id>19143, 5237, 5190, 19401, 23659, 865874, 865879, 869706, 416, 871152, </team_members_id><team_members_names><![CDATA[Mario  Ščetar, Sanja Vidaček Filipec, Tibor Janči, Iva Čanak, Damir Klepac, Frederic Debeaufort, Nasreddine Benbettaieb, Petra Pišonić, Ksenija Markov, Tea Sokač Cvetnić, ]]></team_members_names><keywords_hr><![CDATA[Jestive prevlake, aktivno pakiranje, prirodni konzervansi, svježa Jadranska riba, antioksidansi, antimikrobna tvar, rok trajnosti ribe ]]></keywords_hr><keywords_en><![CDATA[Edible coatings, active packaging, natural preservatives, Adriatic fresh fish, antioxidant, antimicrobial, fish shelf-life]]></keywords_en><summary_hr><![CDATA[ActCoFISH je multidisciplinaran projekt koji objedinjuje prehrambenu tehnologiju, biopolimerne materijale, mikrobiologiju i održivoj proizvodnji kako bi se postigao značajan znanstveni doprinos u pakiranju hrane. Problematika je usmjerena na tehnologiju jestivog aktivnog pakiranja koje kroz održivi koncept razvoja pretvara biopolimere  u visokovrijedne jestive prevlake za svježu ribu. Projekt je opisan kroz 7 znanstvenih ciljeva, a usmjeren je na razvoj i karakterizaciju novih formulacija biopolimera za jestive prevlake. Prevlake će biti izrađene od prirodnih resursa. Formulacije biopolimera biti će obogaćene prirodnim bioaktivnim spojevima s antioksidativnim i antimikrobnim djelovanjem gdje će ActCoFISH pružiti više od obične prevlake za hranu. Formulacije će biti optimizirane za očuvanje kvalitete i inhibiciju mikrobnog kvarenja svježe jadranske ribe s ciljem produženja roka trajnosti. Biopolimeri koristiti će se kao idealni zaštitni nosači prirodnih aktivnih spojeva iz mediteranskih biljaka i nusproizvoda njihove prerade i/ili iz morskih algi. Novodizajnirane formulacije na bazi biomase bit će detaljno karakterizirane (fizikalno-kemijska, barijerna, površinska, toplinska, strukturna, funkcionalna svojstva i kontrolirano otpuštanje aktivne komponente) kako bi se stvorila nova paradigma o svojstvima vezanim uz formulaciju/strukturu koja su neophodni parametri za učinkovitu primjenu prevlaka odnosno njihovu funkcionalnost. Nadalje, prevlake će se nanositi na svježu bijelu i plavu ribu iz Jadranskog mora, važnu oznaku hrvatskog gospodarstva. Razradit će se sinergijski učinak novih aktivnih prevlaka i pakiranja u modificiranoj atmosferi. ActCoFISH je vođen još neiskorištenom prilikom otkrivanja nove generacije aktivnih materijala i njihovom primjenom za pakiranje ribe. Znanstveni učinak istraživanja je vrlo velik, a moguć je i transfer znanja i tehnologije budući se ActCoFISH bavi globalnim problemom nepotrebnih gubitaka hrane odgovornim korištenjem prirodnih resursa.]]></summary_hr><summary_en><![CDATA[ActCoFISH is a multidisciplinary project that unites expertise in food science, biopolymer materials, microbiology and sustainable production to achieve a scientific breakthrough to food packaging. Project is focused on active packaging technology that sustainably upgrades abundant biopolymers into high-value active edible coatings for fresh fish. Project is described through 7 scientific goals and is focused on the development and characterisation of new designed biopolymer formulations for edible coatings. Coatings will be made from natural resources. Biopolymers will be enriched with natural bioactive compounds with antioxidant and antimicrobial activity where ActCoFISH will provide more than just a food coating. Formulations will be optimised to preserve the quality and inhibit microbial spoilage of fresh Adriatic fish in order to extend its shelf-life. Natural biopolymers will be used as an ideal protective carrier of natural active compounds from Mediterranean plants and by-products of their processing and/or from seaweed. Newly designed biobased formulations will be characterised in detail (physico-chemical, barrier, surface, thermal, structural, functional properties and controlled release of active compounds) to create a new paradigm on formulation/structure related properties that are indispensable parameters for effective coating application or their functionality. Furthermore, coatings will be applied on fresh white and blue fish from the Adriatic Sea, an important label of the Croatian economy. The synergistic effect of new active coatings and modified atmosphere packaging will be elaborated. ActCoFISH is driven by still unexplored opportunity to unravel the next generation of active materials for fish packaging. Although the scientific impact of this research is very high, transfer of knowledge and technology is possible since ActCoFISH addresses the global problem of unnecessary food losses through the responsible use of natural resources.]]></summary_en></project><project>
<id>15417</id><title_hr><![CDATA[Pelud u Jadranskom moru: dinamika unosa, kemijska karakterizacija i utjecaj na primarnu produkciju]]></title_hr><title_en><![CDATA[Pollen in the Adriatic Sea: input dynamics, chemical characterization and effects on primary production]]></title_en><user_id>106</user_id><user_firstLast_name>Slađana Strmečki Kos</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-6348</code><acronim><![CDATA[POLLMAR]]></acronim><duration>20.12.2023 - 19.12.2027</duration><status>U tijeku</status><financ_value>131.395,59 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Interdisciplinarne prirodne znanosti, Kemija, </scie_field_hr><scie_field_en>Interdisciplinary natural sciences, Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>81, 85, 17873, 25845, 595, 4209, 7339, 1175, 4131, 865785, 865917, 26617, 25777, 22653, 872981, </team_members_id><team_members_names><![CDATA[Blaženka Gašparović, Abra Penezic, Ana Cvitešić Kušan, Saranda Bakija Alempijević, Dijana Jadreško, Nadica Maltar Strmečki, Ivana Hrga, Adriana Kenđel, Suzana Sopčić, Helena Ribeiro, Leszek Marynowski, Božena Mitić, Andrea Milinković, Dario Hruševar, Terezija Galeković, ]]></team_members_names><keywords_hr><![CDATA[Pelud, atmosfersko taloženje, površinski slojevi morske vode, peludni organski materijal, fitoplanktonska produkcija.]]></keywords_hr><keywords_en><![CDATA[Pollen, atmospheric deposition, surface seawater layers, subpollen organic material, phytoplankton production.]]></keywords_en><summary_hr><![CDATA[Scenariji budućih klimatskih promjena predviđaju da će se koncentracije peludi u zraku povećati jer se vrijeme oprašivanja biljaka produljuje zbog povećanih koncentracija CO2 u atmosferi i viših temperatura. Interakcije kopna i mora postat će intenzivnije, a budući da pelud sadrži značajnu količinu organskih hranjivih tvari, jedan je od alohtonih unosa u prirodne vode koji može promijeniti dinamiku ekosustava. Iako je unos peludi u slatkovodne sustave (osobito jezera) vrlo dobro proučen, nema informacija o utjecaju unosa peludi na primarnu proizvodnju u moru, koja čini bazu morske trofičke piramide. Fenomen žute morske površine dokumentiran je posljednjih godina duž jadranske obale od Kvarnera, Šibenika, Splita do Dubrovnika, a ne zna se koliko dugo pelud ostaje na površini, koliko se širi u dubinu i kakve posljedice ima u morskoj vodi. Interdisciplinarni projekt POLLMAR okupit će stručnjake iz atmosferskih kemije, aerobiologije, biogeokemije mora i oceanologije kako bi po prvi put proučavali unos peludi iz zraka u obalna područja srednjeg Jadrana tijekom glavne sezone oprašivanja od veljače do srpnja. Laboratorijskim eksperimentima istražit će se dinamika pucanja različitih peludnih zrnaca u uvjetima morske i bočate vode te će se identificirati i kvantificirati organski peludni materijal i karakterizirati onečišćivala koji se adsorbiraju na površini peludi. Provest će se mikrokozmos eksperiment inkubacije morske vode sa prikupljenim peludnim zrncima u usporedbi s otopljenim organskim peludnim tvarima koji će razjasniti utjecaj donosa peludi na primarnu proizvodnju. Ovo istraživanje je relevantno za Jadransko more, ali i druga oligotrofna obalna područja Sredozemlja koja mogu brzo reagirati na okolišni stres, a posebno na povremene i prekomjerne unose hranjivih tvari s kopna i iz atmosfere.]]></summary_hr><summary_en><![CDATA[Future climate change scenarios predict that pollen concentrations in the air will increase as pollination period lengthen due to increased atmospheric CO2 concentrations and higher temperatures. Land-sea interactions will become more intense, and because pollen contains a significant amount of organic nutrients, it is one of the allochthonous inputs to natural waters that may alter ecosystem dynamics. Although pollen input to freshwater systems (especially lakes) has been well studied, there is no information on effects of pollen input on phytoplankton production, a base of the marine trophic pyramid, in nearshore seawater. The phenomenon of yellow sea surface has been documented in recent years along the Adriatic coastal region from Kvarner, Šibenik, Split to Dubrovnik, and no one knows how long the pollen remains on the surface, how far it spreads at depth, and what consequences it leaves in the seawater. The interdisciplinary POLLMAR project will bring together experts in atmospheric chemistry, aerobiology, marine biogeochemistry, and oceanology to study, for the first time, the aerial pollen flux into the coastal areas of the central Adriatic Sea during the main pollination season (February to July). Laboratory experiments will investigate the dynamics of various pollen grain rupture under seawater and brackish water conditions, will identify and quantify the subpollen organic material leached, and will characterize the airborne pollutants that adsorb on the pollen grain surface. Finally, the microcosmos incubation experiment of collected pollen grains compared to dissolved organic subpollen matter will elucidate the effect of pollen input on marine primary production. This research is relevant to the Adriatic Sea as well as other oligotrophic coastal areas of the Mediterranean, which can respond rapidly to environmental stressors, especially occasional and excessive nutrient inputs from land and the atmosphere.]]></summary_en></project><project>
<id>15419</id><title_hr><![CDATA[Relativistička nuklearna višečestična teorija u doba opažanja raznovrsnih signala]]></title_hr><title_en><![CDATA[Relativistic nuclear many-body theory in the multimessenger observation era]]></title_en><user_id>11296</user_id><user_firstLast_name>Nils Paar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-7773</code><acronim><![CDATA[RELANUM]]></acronim><duration>16.12.2023 - 15.12.2027</duration><status>U tijeku</status><financ_value>169.604,58 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>780, 24, 866020, 866009, 867617, 869926, 869906, 873068, </team_members_id><team_members_names><![CDATA[Tamara Nikšić, Dario Vretenar, Amandeep Kaur, Ante Ravlić, Polychronis Koliogiannis Koutmiridis, Tanmoy Ghosh, Rade Smolović, PAULA PEĆANIĆ, ]]></team_members_names><keywords_hr><![CDATA[Nuklearna struktura, nuklearni prijelazi, višečestična teorija, energijski funkcional gustoće, nukleosinteza, neutronske zvijezde, supernova]]></keywords_hr><keywords_en><![CDATA[nuclear structure, nuclear transitions, many-body theory, density functional theory, nucleosynthesis, neutron stars, supernova]]></keywords_en><summary_hr><![CDATA[Razvoj novih eksperimentalnih postrojenja s radioaktivnim ionskim snopovima i opažanja raznovrsnih signala sa zvijezda pomoću detektora gravitacijskih valova, te opažanja rendgenskog zračenja, vidljivog svjetla, gama zračenja i neutrina, otvara nove perspektive za istraživanje ključnih pitanja u nuklearnoj astrofizici, posebice sinteze kemijskih elemenata težih od željeza u okruženjima supernove i dvojnih sustava neutronskih zvijezda. Glavni cilj ovog projekta je razviti univerzalnu mikroskopsku teoriju za opis slabo vezanih jezgara, njihovih pobuđenja, procesa slabog međudjelovanja, reakcija induciranih neutronima i nuklearne fisije u uvjetima konačne temperature u okruženju zvijezda, uključujući učinke deformacije i korelacija sparivanja, u formalizmu relativističkog energijskog funkcionala gustoće. Uspostavit će se novi teorijski pristup za istraživanje dinamike fisije s poboljšanim opisom učinaka disipacije, koji će omogućiti kvantitativni opis fisije jezgara odgovornih za recikliranje fisijom u procesu brzog uhvata neutrona. Ovim će se studijama uspostaviti veza između svojstava nuklearne fizike na konačnoj temperaturi opisanih u teoriji energijskog funkcionala gustoće i astrofizičkih modela evolucije zvijezda i nukleosinteze u supernovama i spajanju neutronskih zvijezda. Rezultati prvog opažanja gravitacijskih valova iz spajanja neutronskih zvijezda GW170817 i novi eksperimenti raspršenjenja elektrona s narušenjem pariteta, koristit će se za određivanje parametara nuklearne jednadžbe stanja, što je bitno za razumijevanje prirode zvijezda. Znanstveni ciljevi će se realizirati u interdisciplinarnom okviru teorijske nuklearne fizike i astrofizike koji objedinjuje modeliranje složenih sustava, strojno učenje i inovacije računalne znanosti primijenjene u distribuiranom računalnom okruženju. ]]></summary_hr><summary_en><![CDATA[The emergence of novel experimental facilities with radioactive ion beams and multimessenger observations of stellar objects with gravitational wave detectors, and X-ray, visibile light, gamma-rays and neutrino observations, open new perspectives to explore the key questions in nuclear astrophysics, in particular the synthesis of chemical elements heavier than iron in supernova and neutron star merger environments. The major goal of this project is to develop a universal microscopic theory framework to describe weakly bound nuclei, their excitations, weak interaction processes, neutron induced reactions and nuclear fission in finite temperature stellar conditions, including deformation effects and pairing correlations, in the formalism of the relativistic nuclear energy density functional. Novel theory framework will be established for description of the fission dynamics with improved description of the dissipation effects, that will allow quantitative description of the fission modes of nuclei responsible for the fission recycling in rapid neutron capture process. Through these studies, a link will be established between the nuclear physics properties at finite temperature described in the density functional theory and astrophysical models of stellar evolution and nucleosynthesis in supernovae and neutron-star mergers. The observables from the first measurement of gravitational waves from neutron star mergers GW170817, and new experiments with parity violating electron scattering, will be used to establish novel constraints on the nuclear equation of state, that is essential for understanding the nature of stars. Scientific objectives will be realized within the interdisciplinary framework of theoretical nuclear physics and astrophysics that unifies modeling of complex systems, machine learning, and computational science innovations applied in distributed computing environment. ]]></summary_en></project><project>
<id>15420</id><title_hr><![CDATA[Rimski krajolik i dinamika naseljavanja istarskih kolonijskih agera]]></title_hr><title_en><![CDATA[Roman Landscape and settlement dynamics of the Istrian colonial territories]]></title_en><user_id>4408</user_id><user_firstLast_name>Davor Bulić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-5496</code><acronim><![CDATA[RoLand]]></acronim><duration>22.12.2023 - 21.12.2027</duration><status>U tijeku</status><financ_value>116.073,08 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Arheologija, </scie_field_hr><scie_field_en>Archeology, </scie_field_en><institution_hr><![CDATA[Sveučilište Jurja Dobrile u Puli]]></institution_hr><institution_en><![CDATA[Juraj Dobrila University of Pula]]></institution_en><team_members_id>3216, 22964, 25423, 866257, 823, 3440, 871147, </team_members_id><team_members_names><![CDATA[Ana Konestra, Fabian  Welc, Dolores Matika, Kristina Gergeta Sotončić, Robert Matijašić, Katarina Gerometta, Damir Matošević, ]]></team_members_names><keywords_hr><![CDATA[Rimski krajolik, naseljavanje, rimska ruralna nalazišta, arheološka topografija, kolonijski ager, Istra ]]></keywords_hr><keywords_en><![CDATA[Roman landscape, settlement, Roman rural sites, archaeological topography, colonial ager, Istria]]></keywords_en><summary_hr><![CDATA[Projektom se nastoje kontekstualizirati rimska ruralna nalazišta pulskog i porečkog agera u njihovom prirodnom i povijesnom okruženju, a s obzirom na kronološke, demografske, ekonomske te druge društvene i prirodne procese. Terenskim arheološkim istraživanjima prikupljat će se podaci nužni za kronološke, tipološke, topografske i svake druge klasifikacije. Očekuje se povećanje količine topografskih podataka o rimskim ruralnim nalazištima pulskog i porečkog agera, a koji će rezultirati  sistematizacijom podataka u GIS okruženju. Geofizičkim prospekcijama dobit će se uvid u rasprostranjenost i tlocrtnu dispoziciju rimske ruralne arhitekture na odabranim nalazištima.    Geoarheološkom analitikom  namjeravaju se identificirati glavni taložni procesi koji su se odvijali u posljednja dva tisućljeća te procijeniti utjecaj erozije tla na padinama s ciljem razumijevanja obrazaca rimskih nalazišta, te dobiti uvid u preobrazbe okoliša u posljednja dva tisučljeća. Svrha arheobotaničkih analiza odabranih nalazišta je rekonstrukcija okoliša, prehrane i poljoprivrednih aktivnosti. Rezultati koji se nastoje ostvariti keramološkom analitikom jesu definiranje tipo-kronologije keramičkih nalaza i određivanje brojčane pojavnosti pojedinih vrsta/tipova što može pružiti informacije o prirodi pojedinoga lokaliteta, aktivnostima koje su se ondje provodile, uključenosti u šire mreže razmjene i slično.]]></summary_hr><summary_en><![CDATA[The project aims to contextualize the Roman rural sites of Pula and Poreč ager in their natural and historical environment, regarding chronological, demographic, economic and other social and natural processes. Data necessary for chronological, typological, topographic and any other classifications will be obtained with archaeological fieldwork. An increase in the amount of topographical data on the Roman rural sites of the Pula and Poreč agers is expected, which will result in the systematization of data in a GIS environment. Geophysical prospecting will provide insight into the distribution and ground plan of Roman rural architecture at selected sites. Geoarchaeological analysis will identify the main depositional processes that took place in the last two millennia and will assess the impact of soil erosion on the slopes with the aim of understanding the patterns of Roman sites, and to gain insight into environmental transformations in the last two millennia. The purpose of the archaeobotanical analysis of the selected sites is to reconstruct the environment, diet, and agricultural activities. The results of the ceramic analysis will provide the type and chronology of ceramic finds and the determination of the numerical occurrence of certain types, which can provide information about the nature of a particular site, the activities that were carried out there, and the wider exchange networks.]]></summary_en></project><project>
<id>15424</id><title_hr><![CDATA[Istraživanje kvantnih fluktuacija u sustavima hladnih atoma]]></title_hr><title_en><![CDATA[Exploring quantum fluctuations in cold atom systems]]></title_en><user_id>875</user_id><user_firstLast_name>Leandra Vranjes Markic</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-6144</code><acronim><![CDATA[EQUAFLU]]></acronim><duration>18.12.2023 - 17.12.2027</duration><status>U tijeku</status><financ_value>152.650,01 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Science]]></institution_en><team_members_id>4442, 4840, 866287, 6261, 18947, 21303, 869819, 872977, </team_members_id><team_members_names><![CDATA[Petar Stipanović, Jordi Boronat Medico, Ferran Mazzanti Castrillejo, Robert Zillich, Krešimir Dželalija, Nikola Vukman, Ivan Poparić, Marko Korda, ]]></team_members_names><keywords_hr><![CDATA[ultrarijetke kapljice, kvantne fluktuacije, Bose-Einstenov kondenzat, kvantni Monte Carlo, teorija funkcionala gustoće]]></keywords_hr><keywords_en><![CDATA[ultradilute droplets, quantum fluctuations, Bose-Einstein condesate, quantum Monte Carlo, density functional theory]]></keywords_en><summary_hr><![CDATA[Ultra-rijetke kapljice bozonskih mješavina koje su nedavno otkrivene u sustavima hladnih atoma svoju stabilnost duguju kvantnim fluktuacijama. U prethodnim smo istraživanjima pokazali da mnogočestični pristup iz prvih principa, uz kombinaciju kvantnih Monte Carlo simulacija i teorije funkcionala gustoće omogućava pouzdano predviđanje njihovih svojstava. U ovom projektu želimo otići korak u razvoju metoda kvantnog Monte Carla kako bismo istražili efekte kvantnih fluktuacija u tri posebno zanimljiva sustava. Prvo, za komprimirane kapljice bozonskih mješavina želimo odrediti pobuđenja, proučiti vrtloge i ispitati ponašanje primjesa. Drugo, želimo ispitati statičko i dinamičko ponašanje hladnih atoma u periodičnim i kvazi-periodičnim potencijalima, s naglaskom na ultra-rijetke kapljice. Kvantne fluktuacije u takvim sustavima tek su se počele ispitivati, a očekujemo da bi mogle dovesti i do novih faza. Planiramo proučiti dinamiku nakon quenchinga potencijala rešetke ili interakcije kako bismo razumjeli ulogu interakcija u kvazi-periodičnim sustavima daleko od ravnoteže. Neravnotežna mnogočestična fizika postala je fokus interesa mnogih eksperimenata s kvantnim plinovima, a simulacije vremenski ovisnog Varijacijskog Monte Carla idealno su prilagođene za njihovu simulaciju.  Za odabrane sustave odredit ćemo promjene faznog dijagrama s temperaturom, što će osim zajednici ultrahladnih atoma vrijedan uvid dati i zajednici koja proučava adsorpciju kvantnih fluida na supstratima. Kao treće, metodom difuzijskog Monte Carla proučit ćemo bozonsko-fermionsku mješavinu. Variranjem interakcija nadamo se pronaći i karakterizirati režim ultra-rijetke tekućine. Očekujemo da će naša istraživanja biti korisna za vođenje i interpretiranje budućih eksperimenata.]]></summary_hr><summary_en><![CDATA[Ultra-dilute droplets of Bose-Bose mixtures that have been recently discovered in systems of cold atoms owe their stability to quantum fluctuations.  In our previous research we have shown that first principle many-body approach, combining quantum Monte Carlo simulations and density functional theory enables reliable prediction of their properties. In this project we want to take a step forward in developing quantum Monte Carlo methods with the goal of exploring the effects of quantum fluctuations in three particularly interesting systems. First, for compressed droplets of Bose-Bose mixtures we want to determine excitations, study vortices and investigate the behaviour of impurities.  Second, we want to explore static and dynamic behaviour of cold atoms in periodic and quasi-periodic potentials, with emphasis on ultradilute droplets. Quantum fluctuations in these systems are only starting to be explored, and we expect new phases to be uncovered. We plan also to study dynamics after quenching lattice potential or interaction to understand the role of interactions in quasi-periodic systems far from equilibrium. Non-equilibrium many-body physics has become the focus of many quantum gas experiments and  tVMC is ideally suited to simulate them. For chosen systems we will determine the changes of phase diagram with temperature, which will besides the community of ultracold atoms give valuable insight to the community studying adsorption of quantum fluids on substrates. Third, using diffusion Monte Carlo we will study the Bose-Fermi mixture. Varying the interaction we hope to discover and characterize the regime of ultra dilute liquid. We expect our research will be useful for guiding and interpreting future experiments.]]></summary_en></project><project>
<id>15425</id><title_hr><![CDATA[Poboljšanje ekološke učinkovitosti kaveznog uzgoja morskih riba ]]></title_hr><title_en><![CDATA[Enhancing Environmental Performance of Net-Pen Marine Aquaculture]]></title_en><user_id>3217</user_id><user_firstLast_name>Tanja Šegvić Bubić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-7232</code><acronim><![CDATA[EpoMariNet]]></acronim><duration>29.12.2023 - 28.12.2027</duration><status>U tijeku</status><financ_value>142.900,00 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Institut za oceanografiju i ribarstvo]]></institution_hr><institution_en><![CDATA[Institute of Oceanography and Fisheries]]></institution_en><team_members_id>996, 3600, 1029, 178, 5215, 18929, 21299, 866108, 669, 29294, 361, 6017, 864929, 719, 869895, </team_members_id><team_members_names><![CDATA[Ivana Bušelić Garber, Leon Grubišić, Ivana Lepen Pleić, Jasna Maršić-Lučić, Krešimir Markulin, Iva Žužul Vrgoč, Igor Talijančić, David Izquierdo Gomez, Barbara Zorica, Luka Žuvić, Siniša Šegvić, Slavica Matijević, Luka Badurina, Barbara Mikac, Ante Čović-Stanić, ]]></team_members_names><keywords_hr><![CDATA[kavezni uzgoj riba, utjecaj, okoliš, indikatori, tune, prebjezi iz uzgoja, računarni vid]]></keywords_hr><keywords_en><![CDATA[net-pen farming, impact, environment, indicators, tuna, fish farm escapes, computer vision   ]]></keywords_en><summary_hr><![CDATA[Razvoj i rastuća raznolikost morskih proizvoda ključni su aspekti Plave revolucije, paradigme u kojoj akvakultura igra važnu ulogu u osiguravanju ljudske prehrane i sigurnosti hrane diljem svijeta. Međutim, iz ekološke perspektive, intenzivan uzgoj ribe u plutajućim mrežnim kavezima predstavlja najveći rizik za okoliš u usporedbi s drugim sektorima akvakulture, narušavajući biološku raznolikost na razini vrsta, gena i ekosustava. Kako bi se održala konkurentnost i održivi rast akvakulture, istraživački prioriteti ovog prijedloga usmjereni su na smanjenje utjecaja na okoliš, prepoznavanje i poboljšanje rezultata prethodnog HRZZ projekta AquPop, kojeg je vodila PI. Prijedlog uključuje tri međusobno povezana, ali samostalna interdisciplinarna istraživačka paketa s ciljem izgradnje najsuvremenijeg znanja koje može značajno doprinijeti održivoj akvakulturi. Fokus je na istraživanju (1) bioloških i geokemijskih procesa u staništima izloženim organskom unosu s uzgajališta tuna te procjenom biotičkih indeksa i ekoloških pokazatelja za unaprjeđenje alata za praćenje stanja okoliša povezanih s uzgojem tuna, (2) reproduktivne performanse i kapacitet proizvodnje jaja uzgojne tune u kavezima i utjecaj obnove stokova iz jadranskih uzgajališta, te razvoj (3) algoritma za otkrivanje podrijetla ribe (divlje naspram uzgojne) iz digitalnih fotografija korištenjem računalnog vida i polu-nadzornog učenja kako bi se osigurala sljedivost zbjegova u lancu opskrbe i kontrola gospodarskih prijevara. Stoga projekt predviđa i (i) temeljna istraživanja koja vode do novih znanja i podataka od znanstvenog interesa i (ii) primijenjena istraživanja usmjerena na poboljšanje ekološke učinkovitosti industrije akvakulture u EU. Interdisciplinarno okruženje u kombinaciji s multiregionalnom istraživačkom skupinom bit će odlična prilika za razvoj mladih istraživača i alat za izgradnju kapaciteta za povećanje konkurentnosti istraživačke skupine.]]></summary_hr><summary_en><![CDATA[The development of marine products is a core aspect of the Blue Revolution, a paradigm in which aquaculture plays an important role in ensuring human nutrition and food security worldwide. However, from an ecological perspective, intensive fish farming in net pens poses the greatest environmental risk compared to other aquaculture sectors, disrupting biodiversity at the species, gene, and ecosystem levels. To maintain the competitiveness and sustainable growth of aquaculture, the research priorities of this proposal focus on minimizing environmental impacts, recognizing and enhancing the results of the previous HRZZ project AquPop, led by PI. The proposal includes three interrelated but distinct interdisciplinary research tasks aiming to build state-of-the-art knowledge that can contribute significantly to sustainable aquaculture. The focus is on investigating (1) biological and geochemical processes underlying benthic enrichment by tuna farms, along with assessment of biotic indices and environmental indicators to refine tools for monitoring and managing impacts associated with tuna aquaculture, (2) the reproductive performance and egg production capacity of farmed tuna in cages and the impacts of repopulating stocks from Adriatic farms, and the development of (3) an algorithm to detect the origin of fish (wild vs. farmed) from digital images using computer vision and semi-supervised learning to ensure the traceability of farmed escapees into the commercial chain and the control of economic fraud. Therefore, the project envisages both (i) fundamental research leading to new knowledge, data of interest to scientists and (ii) applied research aimed at improving the environmental performance of the aquaculture industry in EU. The interdisciplinary environment combined with a multi-regional research group will be a great opportunity for the development of young researchers and a capacity building tool to increase the competitiveness of the research group.]]></summary_en></project><project>
<id>15427</id><title_hr><![CDATA[Funkcionalno ekološka karakterizacija tala - temelj ekotoksikološke klasifikacije]]></title_hr><title_en><![CDATA[Functional-ecological characterisation of soils - foundation for ecotoxicological classification]]></title_en><user_id>6027</user_id><user_firstLast_name>Branimir Hackenberger Kutuzović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-3233</code><acronim><![CDATA[FUNECOSoil]]></acronim><duration>18.12.2023 - 17.12.2027</duration><status>U tijeku</status><financ_value>158.851,15 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Odjel za biologiju]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Department of Biology]]></institution_en><team_members_id>6391, 26373, 20373, 2551, 20374, 6022, 5901, 26892, 5755, 2824, 873689, </team_members_id><team_members_names><![CDATA[Vera Cesar, Oleg Antonić, Irena Jug, Jadranka Pečar Ilić, Boris Đurđević, Davorka Hackenberger Kutuzović, Goran Palijan, Vesna Peršić, Olga Jovanović Glavaš, Jasenka Antunović Dunić, Ana Josipović, ]]></team_members_names><keywords_hr><![CDATA[funkcionalna ekologija, ekotoksikologija, fauna tla, usluge ekosustava, stabilnost ekosustava tla]]></keywords_hr><keywords_en><![CDATA[functional ecology, ecotoxicology, soil fauna, ecosystem services, soil ecosystem stability]]></keywords_en><summary_hr><![CDATA[Zaštita, restauracija i revitalizacija tla postaje prioritet u strategijama Europske unije. Dosadašnja praksa zaštite tla počivala je uglavnom na mjerenju i korištenju fizikalno kemijskih osobina tla te na sporadičnom istraživanju ekologije i ekotoksikologije pojedinih vrsta ili taksonomskih skupina. Do danas su biotički čimbenici pedosfere vrlo rijetko razmatrani kao diskriminacijski čimbenici pedoloških karakterizacija i klasifikacija. Zadnjih dvadeset godina sve više se spoznaje značaj ekoloških funkcija kao krucijalnih sastojina ekoloških servisa te kao vrlo bitnih čimbenika stabilnosti ekoloških sustava tla. Temeljna hipoteza ovog projektnog prijedloga je kako se tla mogu međusobno razlikovati po taksonomskoj ali i funkcionalnoj biološkoj raznolikosti te kako su razlike u tim biološkim raznolikostima ujedno u visokoj korelaciji s biotičkim potencijalom svakog tla te s ekološkom stabilnosti povezanoj s rasponom ekotoksikološke tolerancije i kapaciteta. Poseban naglasak u planiranju istraživanja dan je arsenu, geološki prirodno prisutnom elementu u tlima Hrvatske. Osim novih znanstvenih saznanja ovaj projektni prijedlog sadrži inovativni pristup u metodologiji istraživanja korištenjem računala opremljenih za znanstveno računalstvo visokih performansi za izvođenje pokusa in silico. Takva metoda istraživanja omogućava optimizaciju i potpuno adaptivni dizajn pokusa dodatno osiguravajući predvidljivost tijeka pokusa i dobivanje rezultata. Rezultati koji se očekuju imat će svoj znanstveni doprinos u teorijskoj ekologiji i ekotoksikologiji u smislu kvantifikacije i metodologije istraživanja ekoloških funkcija u tlima. Primijenjeni značaj rezultata će biti u poljoprivredi i šumarstvu, u dijelu ovih struka koji se bavi suvremenom proizvodnjom uz maksimalno očuvanje tla. Poseban doprinos planiranih istraživanja očekuje se u preporučenim metodama i izmjerenim parametrima kao nužnim podlogama za usaglašavanje legislativnih elemenata Hrvatske u okviru Europske unije.]]></summary_hr><summary_en><![CDATA[Soil protection, restoration and revitalisation are becoming a priority in European Union strategies. Soil protection to date has been based mainly on the measurement and use of soil physical and chemical properties and research into the ecology and ecotoxicology of individual species or taxonomic groups. Until now, the biotic factors of the pedosphere have rarely been considered as distinguishing features for soil characterisations and classifications. In the last twenty years, the importance of ecological functions as crucial components of ecological services and as important factors for the stability of ecological soil systems has been recognised. The primary hypothesis of this proposal is that soils may differ from each other in terms of their taxonomic and functional biodiversity. Furthermore, we hypothesise that differences in these biodiversities are also highly correlated with the biotic potential of individual soils and that ecological stability is related to the range of ecotoxicological tolerance. A special focus of the research is on arsenic, a naturally occurring element in the soils of Croatia. In addition to new knowledge, this proposal includes an innovative approach to research methodology, using high-performance scientific computing to conduct in silico experiments. Such a research methodology enables the optimisation and fully adaptive design of experiments, ensuring predictability of the research process and results yield.The expected results will make a scientific contribution to ecology and ecotoxicology in terms of quantification and research methodology of ecological functions in soils. The applied significance of the results will be in agriculture and forestry, in the part that deals with maximum soil conservation. An exceptional contribution of the planned research is expected in the recommended methods and measured parameters, which will serve as a basis for harmonisation of Croatian legislation within the legal framework of the EU.]]></summary_en></project><project>
<id>15429</id><title_hr><![CDATA[Digitalizacija netoplinskih ekstrakcija proteina iz biljnih nusproizvoda i elektroformiranje kao izlazni proizvod]]></title_hr><title_en><![CDATA[Digitalisation of nonthermal Extraction of proteins from plant by-products and Electroforming as output Product ]]></title_en><user_id>469</user_id><user_firstLast_name>Anet Režek Jambrak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-2207</code><acronim><![CDATA[DEEP]]></acronim><duration>29.12.2023 - 28.12.2027</duration><status>U tijeku</status><financ_value>192.990,00 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Interdisciplinarne biotehničke znanosti, Prehrambena tehnologija, </scie_field_hr><scie_field_en>Interdisciplinary biotechnical sciences, Food technology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Food Technology and Biotechnology]]></institution_en><team_members_id>865483, 5791, 865482, 865484, 3535, 865615, 5587, 865560, 146, 707, 25343, 6380, 26300, 865631, 865717, 25273, 865830, 3287, 4314, 142, 867698, 22617, </team_members_id><team_members_names><![CDATA[Brijesh Tiwari, Janko Diminić, Andrija Sabol, Gulden Goksen, Ena Pecina, Gianpiero Pataro Pataro, Mojca Čakić Semenčić, Yvonne VanderMeer, Antonio Petošić, Hrvoje Juretić, Iva Sabljak, Igor Erceg, Ilija Đekić, Martina Odeljan, Pranav Nakhate, Marinela Nutrizio, Nedeljko Štefanić Štefanić, Nenad Jalšenjak, Anita Slavica, Marko Jurcevic, Anne-Sylvie Tixier, Filip Jukić, ]]></team_members_names><keywords_hr><![CDATA[netoplinske tehnike, ekstrakcije, internet stvari, proteini, održivost, nusproizvodi, elektroraspršivanje, elektropredenje, nanovlakna, RuBisCO]]></keywords_hr><keywords_en><![CDATA[nonthermal processing, extractions, internet of things, proteins, sustainability, byproducts, electrospinning, electrospraying, nanofibres, RuBisCO]]></keywords_en><summary_hr><![CDATA[Industrija 4.0 uključuje automatizaciju i razmjenu podataka u proizvodnim tehnologijama i uključuje cyber-fizički sustav, Internet stvari (IoT), naprednu povezanost i računalstvo u oblaku za transformaciju proizvodnih jedinica u „pametne tvornice“. Cilj i svrha DEEP projekta je korištenje odbačenih listova iz prerade cikle (Beta vulgaris L.) i proizvodnje boba (Vicia faba L.), te provesti zelenu ekstrakciju proteina RuBisCO (Ribuloza-1,5-bisfosfat karboksilaza/oksigenaza) iz lišća. Za ekstrakciju proteina i bioaktivnih spojeva lišća, koristit će se netoplinske  tehnike ultrazvuk visoke snage - US i pulsirajuće električno polje - PEF.  Ideja je koristiti digitalizaciju u netoplinskoj obradi (US i PEF), uz korištenje senzora (za temperaturu, vlažnost, provodljivost, potrošnju energije, tlak itd. kroz pametni IoT sustav). Dakle razvit će se sustav netoplinskih tehnika Interneta stvari (IoT) (NT-IoT-P), za praćenje i optimizaciju procesa ekstrakcije proteina. Zelena ekstrakcija ima mnoge prednosti kao što je povećanje prinosa proteina, bioaktivnih komponenti, korištenje zelenih otapala (voda) umjesto organskih otapala, vođenje kraćeg procesa na sobnoj temperaturi  i dr. Fokus je na smanjenju, recikliranju i ponovnoj upotrebi, prema obradi bez otpada (zero-waste). RuBisCO je najzastupljeniji protein pronađen na zemlji (može sadržavati do 50% ukupnih topljivih proteina koji se nalaze u tkivu lista). RuBisCO je enzim odgovoran za fiksaciju ugljika dobivenog iz atmosferskog CO2 kao dio Calvin-Bensonovog ciklusa. Cilj je ekstrahirati RuBisCO i “upakirati” ekstrakt, primjenom postupaka elektropredenja i elektroraspršivanja (za dobivanje nanovlakana) te usporediti s inkapsulacijom, uobičajenim postupkom isporuke ekstrahiranih bioaktivnih spojeva. Krajnji cilj je mogućnost korištenja vlakana i nanočestica (kapsula) kao dodatak u proizvodima i ambalaži.]]></summary_hr><summary_en><![CDATA[Industry 4.0 includes automation and data exchange in manufacturing technologies and includes cyber-physical system, Internet of things (IoT), advanced connectivity and cloud-computing to transform production units into “smart factories”. The aim of the DEEP project is to use discarded leaves from the processing of beets (Beta vulgaris L.) and the production of faba beans (Vicia faba L.), and to conduct a green extraction of the protein RuBisCO (Ribulose-1,5-bisphosphate carboxylase/oxygenase) from the leaves. For the extraction of proteins and bioactive compounds from the leaves, nonthermal techniques, like high-power ultrasound - US and pulsed electric fields - PEF will be used. The idea is to use digitization in nonthermal processing (US and PEF), with the use of sensors (for temperature, humidity, conductivity, energy consumption, pressure, etc. through a smart IoT system). Therefore, a system of nonthermal Internet of Things (IoT) processing (NT-IoT-P) will be developed for monitoring and optimizing the protein extraction process. Green extraction has many advantages such as increasing the yield of proteins, bioactive components, using green solvents (water) instead of organic solvents, running a shorter process at room temperature, etc. The focus is on reduction, recycling and reuse, towards processing without waste (zero-waste).RuBisCO is the most abundant protein found on earth (it contains up to 50% of the total soluble proteins found in leaf tissue). RuBisCO is the enzyme responsible for fixing carbon derived from atmospheric CO2 as part of the Calvin-Benson cycle. The goal is to extract RuBisCO and &#39;&#39;package&#39;&#39; the extract, using electrospinning and electrospraying procedures (to obtain nanofibers) and compare it with encapsulation, the usual delivery process of extracted bioactive compounds. The ultimate goal is the possibility of using nanofibers and nanoparticles (capsules) as additives in products and packaging.]]></summary_en></project><project>
<id>15430</id><title_hr><![CDATA[Aktivne i rekonfigurabilne elektromagnetske strukture i sustavi]]></title_hr><title_en><![CDATA[Active and Reconfigurable Electromagnetic Structures and Systems]]></title_en><user_id>18913</user_id><user_firstLast_name>Silvio Hrabar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-2351</code><acronim><![CDATA[ACTRESS]]></acronim><duration>15.12.2023 - 14.12.2027</duration><status>U tijeku</status><financ_value>178.790,85 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>6686, 6808, 6555, 7123, 869555, 869559, </team_members_id><team_members_names><![CDATA[Zvonimir Šipuš, Juraj Bartolić, Davor Bonefačić, Igor Krois, Darin Nožina, Srđan Milić, ]]></team_members_names><keywords_hr><![CDATA[elektromagnetizam, metamaterijali, metapovršine, nefosterovski elementi, vremenski promjenjivi elementi, stabilnost, rekonfigurabilnost]]></keywords_hr><keywords_en><![CDATA[electromagnetics, metamaterials, metasurfaces, non-Foster elements, time-varying elements, stabilty, reconfigurability]]></keywords_en><summary_hr><![CDATA[Bežični komunikacijski sustavi velikih brzina prodrli su u sve aspekte naših života. Tradicionalno, elektromagnetski i elektronički dijelovi sustava, kao što su antene, pojačala itd., razvijaju se odvojeno. Međutim, razvoj aktivnih struktura mijenja ovaj pristup i spaja elektromagnetizam i elektroniku.Trenutno, postoje dva glavna izazova: širokopojasni rad antene potreban za visoke brzine prijenosa i implementacija rekonfigurabilnosti koja bi  omogućila prekapčanje snopa,  frekvencijskog opsega i polarizacije. Nedavno je Elektromagnetska grupa  Sveučilišta u Zagrebu ponudila nekoliko rješenja problema širokopojasnosti na temelju valovoda sa stop-pojasom i nefosterovskih mreža. Ova rješenja pružaju vrlo veliku, ali unaprijed određenu širinu pojasa koja se ne može mijenjati. Isti nedostatak vrijedi i za polarizaciju i dijagram zračenja. U predloženom istraživanju pokušati će se prevladati ta ograničenja i realizirati rekonfigurabilnost kroz tri komplementarna pristupa.Prvi pristup temelji se na sličnosti između nefosterovskih i vremenski promjenjivih elemenata. To omogućuje izvedbu stabilnog integriranog nefosterovskog/vremenski promjenjivog elementa koji  oponaša  proizvoljnu pozitivnu/negativnu mrežu i postiže rekonfigurabilnost bolju od klasične PIN/varaktorske mreže.Drugi pristup odnosi se na upravljačke podsustave koji omogućuju rekonfigurabilnost nefosterovih/vremenski promjenjivih mreža putem vremenske modulacije. Tako bi se promjenom modulacijske funkcije isto sklopovlje ponašalo kao različite pozitivne/negativne mreže.Treći pristup temelji se na višeslojnim metapovršinama koje se mogu rekonfigurirati pomicanjem ili rotiranjem pojedinih slojeva. Ova mehanička rekonfigurabilnost će biti zamijenjena elektroničkom, ugradnjom nefosterovskih/vremenski promjenjivih elemenata.Na kraju, sva tri pristupa bit će integrirana u aktivnu elektromagnetsku metapovršinu s rekonfigurabilnim frekvencijskim pojasom, polarizacijom i dijagramom zračenja]]></summary_hr><summary_en><![CDATA[High-speed wireless communication systems penetrated all aspects of our lives.Traditionally, the electromagnetic and electronic parts of the system, such as antennas, amplifiers, etc., have been developed separately. However, recent advances in active structures are changing this approach and bridging electromagnetics and electronics. Currently, there are two main challenges: achieving wide antenna operating bandwidth required for high bit rates, and implementing reconfigurability to enable beam and frequency band switching, and polarization control. Recently, the electromagnetic group at University of Zagreb has offered several solutions to the bandwidth problem based on gap waveguides and non-Foster networks. These solutions provide a very large but predetermined bandwidth that cannot be changed. The same drawback applies to polarization or radiation pattern. In the proposed research, we try to overcome these limitations and realize reconfigurability through three complementary approaches. The first approach is based on the similarities between non-Foster and time-varying elements. It will enable the construction of a stable integrated non-Foster/time-varying element that behaves like an arbitrary positive/negative network and improves reconfigurability beyond the classical PIN/varactor network.The second approach addresses control subsystems that allows reconfigurability of non-Foster/time-varying networks through special modulating function. The same hardware operates as an arbitrary positive/negative network by simply changing the modulation function.The third approach is based on multilayer metasurfaces that can be made reconfigurable by moving or rotating certain layers. This mechanical reconfigurability will be replaced by its electronic equivalent by embedding non-Foster/time-varying elements.Finally, all three approaches will be integrated into an active electromagnetic metasurface with reconfigurable frequency band, polarization, and radiation pattern.]]></summary_en></project><project>
<id>15440</id><title_hr><![CDATA[Višerječni izrazi u hrvatskome jeziku – leksikološki, računalnolingvistički i glotodidaktički pristup ]]></title_hr><title_en><![CDATA[Multiword Expressions in Croatian - Lexicological, Computational Linguistic and Glottodidactic Approach]]></title_en><user_id>19128</user_id><user_firstLast_name>Goranka Blagus Bartolec</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-7697</code><acronim><![CDATA[MWE-Cro]]></acronim><duration>31.12.2023 - 30.12.2027</duration><status>U tijeku</status><financ_value>73.719,73 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filologija, </scie_field_hr><scie_field_en>Philology, </scie_field_en><institution_hr><![CDATA[Institut za hrvatski jezik]]></institution_hr><institution_en><![CDATA[Institute of Croatian Language]]></institution_en><team_members_id>5768, 19110, 12671, 865546, 865467, 865466, 4220, 3092, 872963, </team_members_id><team_members_names><![CDATA[Barbara Kovačević, Ivana Matas Ivanković, Petra Bago, Magdalena Baer, Mirjana Snjaric, Gorana Duplančić Rogošić, Antonia Ordulj, Ivana Kurtović Budja, Martina Pliestić, ]]></team_members_names><keywords_hr><![CDATA[mrežna baza, višerječni izrazi, leksikologija, glotodidaktika, hrvatski jezik]]></keywords_hr><keywords_en><![CDATA[online database, multiword expressions, lexicology, glottodidactics, Croatian]]></keywords_en><summary_hr><![CDATA[Glavni je cilj projekta razviti mrežno pretraživ i javno dostupan repozitorij višerječnih izraza hrvatskoga jezika s opisom njihovih gramatičkih i značenjskih obilježja. Obrađeni podatci bit će koristan izvor za: 1. različita jezikoslovna istraživanja, 2. unaprjeđenje korpusnih alata za prepoznavanje višerječnih izraza (općih i stručnih kolokacija, frazema, poslovica, pragmema, gramatičkih sveza), 3. istraživanja na kontrastivnoj razini za potrebe prevođenja, izrade paralelnih korpusa te u poučavanju i učenju hrvatskoga kao inoga jezika. Kategorizacija višerječnih izraza temeljit će se na postojećim teorijskim opisima višerječnih izraza, osobito onim kojima su određene suvremene smjernice proučavanja takvih sveza u 21. stoljeću, što uključuje primjenu i unapređenje korpusnih i računalnih tehnologija, primjenu višerječnih izraza u govoru te njihovu percepciju pri usvajanju hrvatskoga kao inoga jezika. U okviru projekta razvit  će se 5 baza – opća baza višerječnih izraza, baza frazema, baza hrvatskih poslovica, baza višerječnih izraza u okviru hrvatskoga kao inoga jezika, baza glagolskih kolokacija hrvatskoga, poljskoga, njemačkoga i engleskoga jezika. Poslovice kao plodna skupina višerječnih izraza temeljenih na izricanju narodnih mudrosti, za razliku od frazema, znatno su manje zastupljene u suvremenim leksikografskim izvorima, korpusima i nastavi Hrvatskoga jezika, što nameće potrebu njihova uvrštavanja u mrežnu bazu kako bi bile dostupne i sadašnjim i budućim, izvornim i stranim, govornicima hrvatskoga jezika. Glagolske kolokacije u hrvatskom i drugim jezicima važna su i složena skupina višerječnih izraza, a izrada baze glagolskih kolokacija kao i drugih višerječnih sveza olakšala bi i unaprijedila poučavanje hrvatskoga kao inoga jezika. Baze višerječnih izraza danas su jedan od temeljnih jezičnih resursa svakoga jezika te ključna karika u razvoju obrade prirodnoga jezika. Držimo stoga da je izrada takva mrežnog resursa strateški važna za hrvatski jezik.  ]]></summary_hr><summary_en><![CDATA[The main objective of the project is to develop an online searchable and publicly available repository of multiword expressions (MWEs) in Croatian with a description of their grammatical and semantic features. Processed data will be a useful source for: 1 various linguistic researches, 2 improvement of corpus tools for detecting MWEs (collocations, idioms, proverbs, grammatical phrases), 3 the contrastive research applicable in translation, creating parallel corpora, and learning Croatian as a foreign language. The classification of MWEs will be based on the existing theoretical descriptions, especially those that have determined the modern guidelines for the study of such phrases in the 21st century, which includes the improvement of corpus and computer technologies, the use of MWEs in a spoken context and adopting Croatian as foreign language. The project proposal includes the development of 5 databases – a basic database of MWEs, an idiom database, a proverb database, a database of MWEs in Croatian as foreign language, a database of verb collocations in Croatian, Polish, German, and English. Proverbs, based on the folk wisdom, unlike idioms, are less represented MWEs in contemporary lexicography, corpora and teaching of Croatian, which imposes the need to include them in an online database so that they are available to native and non-native speakers of Croatian. Verb collocations in Croatian and other languages are an important and complex group of MWEs that require special attention when learning the language. Development of the Verb collocations database, as well as other multiword expressions, would facilitate and thus improve the teaching of Croatian as a second and foreign language. Today, databases of MWEs are one of the fundamental linguistic resources of every language and a key link in the improvement of natural language processing. We therefore believe that the development of such a resource is strategically important for Croatian.]]></summary_en></project><project>
<id>15441</id><title_hr><![CDATA[Napredni poluvodički elementi u graničnim područjima upotrebe]]></title_hr><title_en><![CDATA[Advanced Semiconductor Devices at Their Limits]]></title_en><user_id>6955</user_id><user_firstLast_name>Tomislav Suligoj</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-5294</code><acronim><![CDATA[SemiLimit]]></acronim><duration>20.12.2023 - 19.12.2027</duration><status>U tijeku</status><financ_value>194.649,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, Temeljne tehničke znanosti, Interdisciplinarne tehničke znanosti, </scie_field_hr><scie_field_en>Electrical engineering, Basic engineering sciences, Interdisciplinary technological sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>22510, 7054, 861727, 6081, 6083, 865117, 6852, 871447, 872917, </team_members_id><team_members_names><![CDATA[Lovro Marković, Mirko Poljak, Filip Bogdanović, Josip Žilak, Tihomir Knežević, Borna Požar, Marko Koričić, Azra Tabaković, Paula Bartulović, ]]></team_members_names><keywords_hr><![CDATA[Poluvodički elektronički elementi, HCBT, CMOS tehnologija, fotodetektor, SPAD, amorfni bor, niskotemperaturna elektronika, sigurno područje rada ]]></keywords_hr><keywords_en><![CDATA[Semiconductor devices, HCBT, CMOS technology, photodetector, SPAD, amorphous boron, low-temperature electronics, safe operating area]]></keywords_en><summary_hr><![CDATA[Cilj predloženog projekta je istražiti svojstva naprednih poluvodičkih elektroničkih elemenata na granicama njihovih karakteristika te izvan konvencionalnih radnih okruženja, omogućujući potpuno iskorištavanje njihovog potencijala i/ili proširenje područja primjene. Demonstrirat će se rad bipolarnog tranzistora s horizontalnim tokom struje (HCBT) na granici i izvan linearnog područja rada (LOA) i RF sigurnog područja rada (RF SOA), posebno u režimu visokih napona (iznad proboja), visokih struja i visoke RF snage, te će se povezati s tehnološkim parametrima. Niskotemperaturnom karakterizacijom HCBT-a dobit će se slika o potencijalu jednostavne, silicijske, CMOS-kompatibilne tehnologije za kriogene primjene poput kvantnih računala, uzimajući u obzir sve relevantne fizikalne efekte.Nove strukture lavinskih fotodioda za detekciju jednog fotona (SPAD) bit će projektirane u visokonaponskoj HV CMOS tehnologiji s ciljem optimiranja efikasnosti detekcije i smanjenja šuma. Izmjerene karakteristike procesiranih SPAD-ova koristit će se za procjenu utjecaja tehnoloških parametara na njihove električke i optičke karakteristike. Projektirat će se 2D matrica SPAD-ova zajedno s pripadajućim sklopovima za očitavanje te će se posebno optimirati za brzinu odziva i minimalnu površinu pogodnu za ekstremne uvjete rada. SPAD-ovi i matrice će također biti procesirane u skaliranoj CMOS tehnologiji, što će rezultirati detaljnom usporedbom dvaju tehnoloških čvorova.Detaljno će se okarakterizirati duboki defekti na svim granicama materijala u Pure(Ga)B diodama koji su ključni za njihova električka i optička svojstva u stacionarnoj, AC i tranzijentnoj domeni od sobne do kriogenih temperatura. Opisat će se i temperaturne ovisnosti vertikalnog i lateralnog vođenja struje u PureB i PureGaB slojevima na različitim podlogama (Si, SiGe, Ge). Razvit će se skalabilni 2D model diode u širokom temperaturnom području.]]></summary_hr><summary_en><![CDATA[The goal of the proposed project is to explore the properties of advanced semiconductor devices at the limits of their characteristics and beyond conventional working environments, enabling full utilization of their potential and/or widening their application spectrum. Operation of Horizontal Current Bipolar Transistors (HCBTs) at and beyond the limits of their linear operating area (LOA) and RF safe operating area (RF SOA) will be demonstrated, specifically in high-voltage (above breakdown), high-current and high RF power regimes, and related to their technology parameters. Low-temperature characterization of HCBT will assess the potential of low-cost, pure-Si, CMOS-compatible technology for cryogenic applications such as quantum computing, addressing all relevant physical effects.Novel structures of single-photon avalanche diodes (SPADs) will be designed in high-voltage CMOS technology with the aim to optimize their detection efficiency and noise performance. The measured characteristics of fabricated SPADs will be used to assess the impact of technology parameters on their electrical and optical performance. A 2D SPAD array together with the associated readout electronics will be designed and particularly optimized for timing performance and layout area suitable for harsh environments. The SPADs and arrays will also be fabricated in a down-scaled CMOS technology, which will provide a comprehensive technology comparison between the two nodes.Deep-level defects at all heterointerfaces in Pure(Ga)B diodes, which are critical for their electrical and optical performance, will be thoroughly characterized in steady-state, AC and transient domains from room to deep-cryogenic temperatures. Additionally, the temperature dependence of vertical and lateral conduction in PureB and PureGaB layers on various crystalline substrates (Si, SiGe, Ge) will be examined. A fully scalable 2D device model will be developed for a wide temperature range.]]></summary_en></project><project>
<id>15442</id><title_hr><![CDATA[Novi peptid-oligonukleotid-kromofor konjugati za biokemijsku dijagnostiku i bioaktivnost]]></title_hr><title_en><![CDATA[New peptide-oligonucleotide-chromophore conjugates for biochemical diagnostics and bioactivity]]></title_en><user_id>480</user_id><user_firstLast_name>Ivo Piantanida</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-9829</code><acronim><![CDATA[POC-Sens-Bioact]]></acronim><duration>28.12.2023 - 27.12.2027</duration><status>U tijeku</status><financ_value>179.074,55 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>444, 3684, 865429, 865750, 23618, 25266, 871149, 873012, </team_members_id><team_members_names><![CDATA[Vilko Smrečki, Dijana Pavlović Saftić, Marta Jurković, Jurij Lah, Marija Matković, Mateja Belovari, Bojan Kuridža, Petra Katalinić, ]]></team_members_names><keywords_hr><![CDATA[Peptid-oligoDNA konjugat, DNAzim, fluorescencija, biooslikavanje, bioaktivnost, teranostika]]></keywords_hr><keywords_en><![CDATA[Peptide-oligoDNA conjugate, DNAzyme, fluorescence, bioimaging, bioactivity, theranostics]]></keywords_en><summary_hr><![CDATA[Male organske molekule čija struktura je kontrolirana vanjskim podražajima, na primjer fotokromne boje sposobne reverzibilno mijenjati strukturu pod svijetlom različitih valnih duljina, su u znanstvenom fokusu između ostalog i zbog njihove foto-kontrolirane biološke aktivnosti. S druge strane, konjugati proteina ili peptida s različitim oligoDNA (POC, eng. protein-oligoDNA conjugate) intenzivno se proučavaju zbog  primjena u biološkim istraživanjima molekularnog prepoznavanja, biooslikavanja, DNA nanotehnologije, razvoja dijagnostičkih testova i biosenzora. U prethodnom HrZZ projektu razvili smo multikromoforne peptide i nove fluorescentne boje, neke od njih kontrolirane foto-prekidačem, za različite bioaplikacije. U ovom prijedlogu želimo iskoristiti ranije razvijena znanja i materijal za dizajn, pripravu i karakterizaciju peptid-ALAT KONTOLE-kromofor sustava za biorelevantne ciljeve. Jedna linija je fokusirana na nove foto-kontrolirane peptid-multikromofor sustave koji ciljaju DNA, RNA, protein ili stanične organele; dok bi 2. linija bila bazirana na peptid-oligoDNA(POC)-fotoprekidač sustavima sa dodatnim svojstvom pojačanja signala pomoću DNAzima, koji ovisno o meti mijenja brzinu nastanka obojenog emzimskog produkta. Interakcije novopriređenih sustava s biorelevantnim metama (specifični slijed DNA, RNA, protein ili peptidni aggregat, stanice i/ili stanične organele) bi trebale izdvojiti najperspektivniije biosenzore ili teranostičke spojeve. Istraživanja financirana ovim projektom su na razini supramolekularne kemije, dok za provedbu bioloških eksperimenta na stanicama imamo podršku grupe s odgovarajućom opremom i certifikatima. Prijedlog je u skladu s ciljevima HrZZ-a: a) suradnja s međunarodno prepoznatim inozemnim znanstvenicima, b) osposobljavanje mladih istraživača u međunarodnom istraživačkom okruženju i c) potencijal komercijalizacije novih teranostičkih agensa. Predviđenih 1 487 777.78 HRK i tim od 7 istraživača osiguravaju izvedivost.]]></summary_hr><summary_en><![CDATA[Small organic molecules with structure controlled by external stimuli, e.g. photochromic dyes capable of reversibly changing their structure upon irradiation at different wavelength, are currently in the scientific focus because of their photo-controlled biological activity. On the other hand, conjugates of proteins or peptides with various oligoDNA (protein-oligoDNA conjugates, “POC”) are intensively studied due to applications in the research of molecular recognition, bioimaging, DNA nanotechnology, and development of diagnostic tests and biosensors. In the previous HrZZ project, we developed multichromophore peptides and new fluorescent dyes, some of them controlled by a photo-switch, for various bioapplications. In this proposal, we want to use previously developed knowledge and material for the design, preparation and characterization of the peptide-CONTROL TOOL-chromophore system for biorelevant targets. One researchline is focused on new photo-controlled peptide-multichromophore systems targeting various DNA, RNA, protein or cellular organelles; while the 2nd line would be based on peptide-oligoDNA(POC)-photoswitch systems with the additional feature of signal amplification by DNAzyme, by changes in the formation rate of the coloured enzyme product. Interactions of newly prepared systems with biorelevant targets (specific DNA, RNA, protein or peptide aggregate, cells and/or cell organelles) should single out the most promising biosensors or theranostic compounds. Research is at the level of supramolecular chemistry, while the biological experiments on cells are supported on our institute by team with appropriate equipment and certificates. In line with the HrZZ objectives proposal supports: a) cooperation with internationally recognized foreign scientists, b) training of young researchers in an international research environment and c) the potential for commercialization. The foreseen 197 462.05 EUR and a team of 7 researchers ensure feasibility.]]></summary_en></project><project>
<id>15445</id><title_hr><![CDATA[Ozračavanje amorfnih oksidnih materijala s brzim teškim ionima]]></title_hr><title_en><![CDATA[Swift Heavy Ion Irradiation of Layered Amorphous Oxide Materials]]></title_en><user_id>3498</user_id><user_firstLast_name>Marko Karlušić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-5023</code><acronim><![CDATA[SHIILAOM]]></acronim><duration>15.12.2023 - 14.12.2027</duration><status>U tijeku</status><financ_value>196.943,87 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>2639, 4589, 5657, 866212, 866208, 13039, 871128, </team_members_id><team_members_names><![CDATA[Pavo Dubček, Stjepko Fazinić, Krešimir Salamon, Jacques O&amp;#39;Connell, Aleksi  Leino, Marko Škrabić, Muhammad Alamgeer, ]]></team_members_names><keywords_hr><![CDATA[Brzi teški ion, ionski trag, amorfni materijali, SiO2, Al2O3, MgO]]></keywords_hr><keywords_en><![CDATA[Swift heavy ion, ion track, amorphous materials, SiO2, Al2O3, MgO]]></keywords_en><summary_hr><![CDATA[Cilj predloženog projekta je proučavanje učinaka zračenja brzim teškim ionima na amorfne materijale. Utjecaj ove vrste iona često dovodi do oštećenja na nanoskali koje se naziva ionski trag. Na površini materijala, ionski tragovi mogu se promatrati mikroskopijom atomskih sila i raspršenjem rendgenskih zraka pod malim kutem, dok se ispod površine ovi objekti mogu istražiti pomoću transmisijske elektronske mikroskopije. Danas su simulacije molekularne dinamike (MD) moćan računalni alat koji pomaže istraživačima da bolje razumiju procese koji dovode do stvaranja ionskog traga.Predloženi projekt provodit će se i kao eksperimentalno i kao teorijsko istraživanje. Predlažemo provedbu tri eksperimenta i tri teorijske studije (koristeći MC kod Geant4 i MD kod LAMMPS). Od ovih šest tema do kraja projekta planiramo objaviti šest znanstvenih radova. Projekt također ima za cilj izgraditi naše kapacitete za istraživanje. Sredstvima iz ovog projekta nadogradit će se AFM postav koji već intenzivno koristimo, a također planiramo nadograditi HPC klaster koji će omogućiti naše MD simulacije formiranja ionskog traga. Ovo će osigurati ovu teorijsku liniju istraživanja u našem Institutu, koja se ranije provodila kroz vanjske suradnje. Konačno, unutar treće godine predloženog projekta predlažemo i organizaciju vodeće konferencije u ovom području istraživanja, međunarodne konferencije „Swift heavy ions in matter“ u Hrvatskoj.Za postizanje predloženih istraživačkih ciljeva, naš tim iskusnih istraživača s IRB-a bit će dopunjen kolegama iz inozemstva, kao i postdoktorandom kojeg planiramo angažirati na dvije godine. Naknadno se predviđa i zapošljavanje doktoranda.]]></summary_hr><summary_en><![CDATA[Aim of the proposed project is to study effects of the swift heavy ion irradiation on amorphous materials. Impact of this type of ion often leads to nanoscale damage called an ion track. On the material surface, ion tracks can be observed by atomic force microscopy and small angle X-ray scattering, while in the bulk these nanoscale objects can be investigated using transmission electron microscopy. Nowadays, molecular dynamics (MD) simulations are powerful computational tool that help researchers understand better processes leading to the formation of the ion track. Proposed project will be implemented both as an experimental and theoretical research. We propose to conduct three experiments and also to make three theoretical studies (using MC code Geant4 and MD code LAMMPS). From these six topics we plan to publish six research papers by the end of the project. The project also aims to build our capacities for the research. With the funds from this project, we will upgrade AFM set-up we are already using intensively, and also, we plan to upgrade HPC cluster that will enable our MD simulations of ion track formation. The later will firmly establish this line of theoretical research at our Institute, that previously had to be outsourced. Finally, in the third year of the project we also propose to organize the leading conference in this field of research, i.e. the International conference on &#39;&#39;Swift Heavy Ions in Matter&#39;&#39; in Croatia.To achieve the proposed research objectives, our team of experienced researchers from RBI will be complemented with colleagues from abroad, and also with postdoctoral researcher we plan to hire for two years. Hiring of the PhD student is also anticipated at a later time.]]></summary_en></project><project>
<id>15446</id><title_hr><![CDATA[Genetska i epigenetska regulacija ponašanja induciranog metamfetaminom u D. melanogaster]]></title_hr><title_en><![CDATA[Genetic and epigenetic regulation of behavior induced by methamphetamine in D. melanogaster  ]]></title_en><user_id>69</user_id><user_firstLast_name>Rozi Andretić Waldowski</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-1281</code><acronim><![CDATA[METH2GENE]]></acronim><duration>01.02.2024 - 31.01.2028</duration><status>U tijeku</status><financ_value>128.741,12 eur</financ_value><scie_area_hr>Prirodne znanosti, Biomedicina i zdravstvo, Biotehničke znanosti, Interdiciplinarne znanosti, Društvene znanosti, </scie_area_hr><scie_area_en>Natural sciences, Biomedicine and health sciences, Biotechnical sciences, Interdisciplinary scientific area, Social sciences, </scie_area_en><scie_field_hr>Biotehnologija u biomedicini, Biologija, Biotehnologija, Interdisciplinarne prirodne znanosti, </scie_field_hr><scie_field_en>Biotechnology in Biomedicine, Biology, Biotechnology, Interdisciplinary natural sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci]]></institution_hr><institution_en><![CDATA[University of Rijeka]]></institution_en><team_members_id>4624, 866076, 866080, 866425, 869788, 872962, </team_members_id><team_members_names><![CDATA[Ana Filošević Vujnović, Carla Margulies Margulies, Andreas Ladurner, Ian Maze, Marta Medija, Antea Marjanović, ]]></team_members_names><keywords_hr><![CDATA[geni, epigenetika, ovisnost, metamfetamin, genska regulacija, D. melanogaster]]></keywords_hr><keywords_en><![CDATA[genes, epigenetics, addiction, methamphetamine, gene regulation, D. melanogaster]]></keywords_en><summary_hr><![CDATA[Okolina utječe na epigenetsku modifikaciju kromatina, ekspresiju gena i dovodi do dugoročnih promjena u funkcioniranju mozga. Zlouporaba droga izaziva modifikacije DNA i histona, uzrokuje promjene u genskoj ekspresiji, a time i neuronskoj plastičnosti što definira simptome ovisnosti. U usporedbi sa sisavcima, ništa se ne zna o epigenetskim modifikacijama izazvanim metamfetaminom (METH) u D. melanogaster. To je propust jer D. melanogaster dijeli 64% genetske sličnosti s ljudima i posljednjih desetljeća opsežno se koristi kao model za proučavanje ljudskih bolesti, uključujući ovisnost.Mi smo pokazali da višestruka izloženost volatiliziranom METH-u (vMETH) u mušica dovodi do fenotipske ekspresije neuronske plastičnosti, te da genetske intervencije koje remete redoks ravnotežu sprječavaju njen razvoj. Proteomska analiza pokazuje da vMETH mijenja količinu proteina koji sudjeluju u regulaciji staničnog metabolizma, redoks ravnoteže i epigenetskih promjena, što smo potvrdili farmakološkim i biokemijskim pokusima. To ukazuje da metabolizam i oksidativni status utječu na epigenetske modifikacije inducirane METH-om. Hipotezu ćemo testirati na mušicama izloženim vMETH-u i na sojevima koje smo dobili pomoću umjetne selekcije za samoadministraciju METH-a, soju s visokom preferencijom (HP) i visokom averzijom (HA).Naš glavni cilj je opisati kako METH dovodi do epigenetskih promjena u D. melanogaster što će pružiti smjernice za translacijske studije koje će pomoći u liječenju ovisnosti. Da bismo to postigli koristiti ćemo najsuvremenije tehnike za nepristranu identifikaciju svih posttranslacijskih modifikacija na histonima i definirati područja odmotanog kromatina koja su permisivna za ekspresiju gena. Dobiveni podaci pomoći će nam u formuliranju hipoteza istraživanja u kojima ćemo korelirati biokemijske, genetske i farmakološke manipulacije s fenotipskim promjenama. Cilj je steći razumijevanje molekularnih mehanizama koji povezuju zlouporabu METH-a s promjenama u ponašanju.]]></summary_hr><summary_en><![CDATA[The environment affects epigenetic modification of chromatin, gene expression and leads to long-term changes in brain functioning. Drug abuse causes modifications of DNA and histones, changes in gene expression  and neuronal plasticity, which defines the symptoms of addiction. Compared to mammals, nothing is known about methamphetamine (METH)-induced epigenetic modifications in D. melanogaster. This is an omission because D. melanogaster shares 64% genetic similarity with humans and has been used extensively in recent decades as a model to study human diseases, including addiction.We have shown that multiple exposure to volatilized METH (vMETH) in flies leads to the phenotypic expression of neuronal plasticity, and that genetic interventions that disturb the redox balance are preventing it. Proteomic analysis shows that vMETH changes the amount of proteins involved in the regulation of cellular metabolism, redox balance and epigenetic changes, which we confirmed with pharmacological and biochemical experiments, indicating that metabolism and oxidative status influence METH-induced epigenetic modifications. We will test the hypothesis in flies exposed to vMETH and in strains obtained by selection for METH self-administration, a high preference (HP) and a high aversion (HA) strain.Our main goal is to describe how METH leads to epigenetic changes in D. melanogaster that will provide guidance for translational studies that will help in the treatment of addiction. In order to achieve this, we will use state-of-the-art techniques for the unbiased identification of all post-translational modifications on histones and define regions of unwound chromatin that are permissive for gene expression. The obtained data will help us formulate research hypotheses in which we will correlate biochemical, genetic and pharmacological manipulations with phenotypic changes. The goal is to gain an understanding of the molecular mechanisms that link METH abuse to behavioral changes.]]></summary_en></project><project>
<id>15447</id><title_hr><![CDATA[Složene poplave u priobalnoj Hrvatskoj u sadašnjoj i budućoj klimi]]></title_hr><title_en><![CDATA[Compound Flooding in Coastal Croatia under Present and Future Climate]]></title_en><user_id>13460</user_id><user_firstLast_name>Nino Krvavica</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-7598</code><acronim><![CDATA[4C-Flood]]></acronim><duration>19.12.2023 - 18.12.2027</duration><status>U tijeku</status><financ_value>166.932,50 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Građevinarstvo, Interdisciplinarne tehničke znanosti, </scie_field_hr><scie_field_en>Civil engineering, Interdisciplinary technological sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Građevinski fakultet u Rijeci]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Civil Engineering]]></institution_en><team_members_id>25660, 18928, 756, 12395, 6656, 22817, 867576, 869910, 871922, 872974, </team_members_id><team_members_names><![CDATA[Suzana Ilic, Igor Ružić, Josip Rubinić, Ante Šiljeg, Goran Lončar, Damjan Bujak, Marta Marija Bilić, Ivona Petković, Silvija Šiljeg, Lovro Štefan, ]]></team_members_names><keywords_hr><![CDATA[složene poplave, hidrauličko modeliranje, poplave mora, pluvijalne poplave, rizici od poplava, hidrologija, podizanje morske razine]]></keywords_hr><keywords_en><![CDATA[compound flooding, hydraulic modelling, coastal flooding, pluvial flooding, flood risk, hydrology, sea level rise]]></keywords_en><summary_hr><![CDATA[Priobalna područja su osjetljiva na poplave jer su izložena brojnim oceanografskim i hidrološkim događajima, kao što su olujni uspori, ekstremni valovi, visoki protoci rijeka i ekstremne oborine. Međutim, istodobna ili uzastopna pojava više različitih uzroka poplava može dovesti do znatno većih posljedica nego u slučaju njihovog zasebnog djelovanja. Takvi kombinirani događaji se općenito nazivaju složene poplave. Istraživanja provedena na globalnoj razini pokazuju da je najveća vjerojatnost složenih poplava u današnjoj klimi uglavnom koncentrirana duž Sredozemnog mora, a povijesne analize u Europi pokazuju da je najveći broj složenih događaja primijećen duž najsjevernije obale Jadranskog mora. Nažalost, u Hrvatskoj još uvijek nema studija o složenim poplavama, niti na nacionalnoj niti na lokalnoj razini. Ovaj će projekt okupiti znanstvenike iz različitih institucija u Hrvatskoj i inozemstvu s posebnim stručnim znanjem kako bi kvantificirali sadašnji i budući potencijal složenih poplava duž hrvatske obale, analizirali i kartirali opasnosti od složenih poplava na odabranim (posebno ranjivim) pilot područjima u Hrvatskoj i unaprijedili razumijevanje složenih poplava. Neposredni učinak ovog projekta su karte potencijala složenih poplava za hrvatsku obalu i karte opasnosti od složenih poplava za tri pilot područja te inovativni metodološki okvir. Konačni učinak ovog projekta na društvo i gospodarstvo bit će podizanje svijesti, smanjenje ekonomskih i ljudskih gubitaka te jačanje otpornosti priobalnih zajednica na složene poplave.]]></summary_hr><summary_en><![CDATA[Coastal regions are vulnerable to flooding because they are exposed to numerous oceanographic and hydrologic events, such as storm surges, extreme waves, high river flows, and extreme precipitation. However, the consequences of flooding caused by simultaneous or successive floods from different sources are greater than if the floods from these sources had occurred separately. Such combined events are referred to as compound flooding. Global studies indicate that the highest probability of compound flooding in the current climate is mainly concentrated along the Mediterranean Sea, and historical analyses in Europe show that the highest number of compound events was observed along the northernmost coast of the Adriatic Sea. Unfortunately, there are still no studies on compound flooding in Croatia, neither on national nor on local level. This project will bring together scientists from different institutions in Croatia and abroad with specific expertise to quantify the current and future compound flooding potential along the Croatian coast, analyse and map compound flooding hazards in selected pilot areas (particularly vulnerable) in Croatia and increase the general knowledge about the mechanisms of compound flooding. The immediate impact of this project are compound flood potential maps for the Croatian coast, compound flood hazard maps for three pilot areas, and an innovative methodological framework. The ultimate impact of this project proposal on society and the economy will be to raise awareness, reduce economic and human losses, and strengthen the resilience of coastal communities to compound flooding.]]></summary_en></project><project>
<id>15448</id><title_hr><![CDATA[Selekcija za poslove budućnosti: Valjanost i reakcije kandidata na digitalne selekcijske metode za mjerenje motiva za postignućem i aktivnog otvorenog mišljenja]]></title_hr><title_en><![CDATA[Selecting for the future of work: Validity and applicant reactions to digital selection procedures used to capture achievement motivation and actively open-minded thinking]]></title_en><user_id>3974</user_id><user_firstLast_name>Zvonimir Galic</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-3356</code><acronim><![CDATA[SEL_FOW]]></acronim><duration>31.12.2023 - 30.12.2027</duration><status>U tijeku</status><financ_value>119.404,07 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Psihologija, </scie_field_hr><scie_field_en>Psychology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>866319, 29510, 6601, 23666, 22773, 27640, 866307, 866356, 866333, 873003, </team_members_id><team_members_names><![CDATA[James LeBreton LeBreton, Matej Gjurković, Maja Parmač Kovačić, Nikola Erceg, Mitja Ružojčić, Antun Palanović, Kaja Damnjanović, Nataša Juničić, Markus Langer, Alma Džafić, ]]></team_members_names><keywords_hr><![CDATA[profesionalna selekcija, budućnost rada, motiv za postignućem, aktivno otvoreno mišljenje, strojno učenje, analiza teksta, intervju]]></keywords_hr><keywords_en><![CDATA[personnel selection, future of work, achievement motive, active open-minded thinking, machine learning, text analysis, interview]]></keywords_en><summary_hr><![CDATA[Povećana automatizacija korištenjem umjetne inteligencije (UI) mijenja svijet rada velikom brzinom (Malhotra, 2021.). Projekt koji predlažemo bavi se razvojem i validacijom digitalnih selekcijskih postupaka (DSP) koji bi se mogli koristiti u profesionalnoj selekciji za procjenu karakteristika zaposlenika potrebnih za radna mjesta budućnosti. U središtu ovog projekta je procjena korisnosti postupaka strojnog učenja za procjenu psiholoških konstrukata u selekciji, polje istraživanja koje je gotovo potpuno neistraženo, uz nekoliko važnih iznimaka (npr. Campion et al., 2016.; Hickman et al., 2021.; 2022., Holtrop et al. ., 2022). U okviru ovog projekta želimo se fokusirati na korištenje računalno potpomognute analize teksta i automatiziranih video intervjua/video analitike za mjerenje specifičnih psiholoških konstrukata - motiva za postignućem i aktivnog otvorenog mišljenja kao osobina presudnih za radna mjesta budućnosti. Unutar četverogodišnjeg projekta planiramo provesti niz studija čiji će glavni ishod biti testovi valjanosti i reakcija kandidata na algoritme strojnog učenja za procjenu tih psiholoških karakteristika putem računalno potpomognute analize tekstualnih i multimodalnih podataka (tj. verbalne i neverbalne podatke) prikupljenih video intervjuom.]]></summary_hr><summary_en><![CDATA[Increased automation through the use of artificial intelligence (AI) has been changing the world of work at a rapid pace (Malhotra, 2021).  The project we are proposing deals with the development and validation of digital selection procedures (DSP) that could be used in personnel selection to assess employee characteristics needed for the future workplaces. At its core is the evaluation of the usefulness of machine learning (ML) procedures to assess psychological constructs within personnel selection, a research field that is almost untouched with few notable exceptions (e.g., Campion et al., 2016; Hickman et al., 2021; 2022, Holtrop et al., 2022). Within this project we want to focus on the use of computer-aided text analysis and automated video interviews/video analytics for the measurement of specific psychological constructs - achievement motive and actively open-minded thinking as the traits essential for the future workplace. Within the course of the four-year project we plan to conduct a set of studies whose main outcome will be tests of validity and applicant reactions to ML algorithms for assessing these psychological characteristics using textual and multimodal data (i.e., verbal and non-verbal data) .]]></summary_en></project><project>
<id>15450</id><title_hr><![CDATA[Razvoj numeričkih metoda za modeliranje nove generacije naprednih kompozitnih konstrukcija]]></title_hr><title_en><![CDATA[Development of Numerical Methods in Modelling New Generation of Advanced Composite Structures]]></title_en><user_id>12906</user_id><user_firstLast_name>Ivica Smojver</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-8845</code><acronim><![CDATA[DENNGA]]></acronim><duration>31.01.2024 - 30.01.2028</duration><status>U tijeku</status><financ_value>172.419,71 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Zrakoplovstvo, raketna i svemirska tehnika, Strojarstvo, </scie_field_hr><scie_field_en>Aerospace, missile and space engineering, Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>13620, 1245, 602, 869826, </team_members_id><team_members_names><![CDATA[Darko Ivančević, Tomislav Filetin, Tatjana Haramina, Fran Ušurić, ]]></team_members_names><keywords_hr><![CDATA[Konstitutivni modeli, numerička metodologija, 3D printani kompoziti, samo-zacjeljivanje, vitrimeri]]></keywords_hr><keywords_en><![CDATA[Constitutive models, numerical methodology, 3D printed composites, self-healing, vitrimers]]></keywords_en><summary_hr><![CDATA[Projekt je usmjeren na razvoj numeričke metodologije za inovativne kompozitne konstrukcije uključujući i one proizvedene aditivnim tehnologijama proizvodnje. Istraživanje je nastavak prethodnog istraživanja koje je bilo usmjereno na računalno modeliranje intrinzično samozacjeljujućih kompozita. Razvijeni višerazinski modeli učinkovito su simulirali ponašanje konstrukcija pod udarnim opterećenjima.U ovom projektnom prijedlogu ovi će modeli biti značajno poboljšani primjenom na nove materijalne sustave kao i na potpuno nove tehnologije primjene. Potencijalni materijali kao npr. bazaltna vlakna kao i vitrimerne matrice će se analizirati u istraživanju. Bazaltna vlakna karakteriziraju dobra kemijska stabilnost i visoka mehanička svojstva što ih čini perspektivnom alternativom široko rasprostranjenim ugljičnim vlaknima. Vitrimeri se od nedavno koriste kao samozacjeljujući polimeri koji imaju mehanička svojstva slična epoksidnim matricama.Drugi dio istraživanja je primjena razvijene i poboljšane numeričke metodologije za određivanje mehaničkih svojstava kompozita proizvedenih aditivnim tehnologijama (3D print - 3DP). Ovdje će fokus biti na numeričkom predviđanju mehaničkih svojstava u funkciji proizvodnih parametara (posmaku, brzine izrade, geometriji kretanja mlaznice i dr.). Budući da trenutno na tržištu ne postoje tehnologije za 3DP samo-obnavljajućih kompozita, ovdje će težište biti na polimernim materijalima kao i vlaknima koja su dostupni na tržištu. Razvoj konstitutivnih modela za ove primjene uključit će višerazinsko modeliranje koje neće biti samo na razini vlakno-matrica već i na razini sloja, odnosno mehaničkih svojstava 3DP slojeva.Numerička metodologija i konstitutivni modeli bit će verificirani odgovarajućim testovima na epruvetama prema standardima, kako bi se ostvarila odgovarajuća pouzdanost, robusnost  i ponovljivost metodologije.]]></summary_hr><summary_en><![CDATA[The project is focused on development of a numerical methodology for innovative composite structures including those manufactured using additive manufacturing. The research is a continuation of previous one that was focused on the computational modelling of intrinsically self-healing composites. The developed multiscale models effectively simulated the behaviour of structures under impact loads.In this project proposal, these models will be significantly improved by applying them to novel material systems as well as to completely new application technologies. Prospective materials as e.g. basalt fibres as well as vitrimeric matrices will be analysed. Basalt fibres are characterized by high chemical stability and high mechanical properties that make them a prospective alternative to widely distributed carbon fibres. Vitrimers have been used recently as a self-healing polymer that has mechanical properties similar to epoxy matrices.The second part of the research is the application of the developed and improved numerical methodology to determine the mechanical properties of composites produced by additive technologies (3D printing - 3DP). Here, the focus will be on the numerical prediction of mechanical properties as a function of manufacturing parameters (shift, manufacturing speed, nozzle movement geometry, etc.). Since there are currently no technologies for 3DP self-healing composites on the market, the focus here will be on those polymer materials as well as fibres that are available on the market. The development of constitutive models for these applications will include multiscale modelling that will not only be at the fibre-matrix level but also at the layer level, i.e. the mechanical properties of the 3DP layers. The numerical methodology and constitutive models will be verified by appropriate test specimens according to the relevant standards, to achieve adequate reliability, robustness and repeatability of the methodology.]]></summary_en></project><project>
<id>15454</id><title_hr><![CDATA[Proteinski hidrolizati kao prirodni preparati u održivom maslinarstvu]]></title_hr><title_en><![CDATA[PROtein hydrolysates as GREen tools in SuStainable olive production]]></title_en><user_id>12403</user_id><user_firstLast_name>Igor Pasković</user_firstLast_name><svouser_id>866181</svouser_id><svouser_firstLast_name>Paula Pongrac</svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-8305</code><acronim><![CDATA[PROGRESS]]></acronim><duration>31.12.2023 - 30.12.2027</duration><status>U tijeku</status><financ_value>199.070,35 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Institut za poljoprivredu i turizam]]></institution_hr><institution_en><![CDATA[Institute of Agriculture and Tourism in Poreč]]></institution_en><team_members_id>26870, 22584, 22579, 27540, 865042, 25397, 867703, 869643, 872908, </team_members_id><team_members_names><![CDATA[Giovanna Speranza, Joško Kaliterna, Paula Žurga, Šime Marcelić, Marija Polić Pasković, Valerija Majetić Germek, Ljiljana Popovic, Ivan Dlačić, Nataly Milovan, ]]></team_members_names><keywords_hr><![CDATA[Biostimulans, proteini, enzimska hidroliza, gljivična infekcija, otpornost biljaka, rendgenska fluorescencija, ATR-FTIR mikroskopija, MeV-SIMS]]></keywords_hr><keywords_en><![CDATA[Biostimulant, proteins, enzymatic hydrolysis, fungal infection, plant resistance, X-ray fluorescence, ATR-FTIR microscopy, MeV-SIMS]]></keywords_en><summary_hr><![CDATA[Ključni izazov moderne poljoprivrede je povećati produktivnost uz istovremeno smanjenje negativnih utjecaja na okoliš i zdravlje ljudi. Biostimulansi su spojevi koji pozitivno utječu na kondiciju i otpornost biljaka na štetnike bez negativnog utjecaja na okoliš i predstavljaju zelenu alternativu sintetskim kemikalijama koje se koriste u ishrani i zaštiti bilja. Cilj projekta je dizajnirati nove biostimulanse iz lista masline, koji je nusprodukt proizvodnje maslinovog ulja, za primjenu u održivom maslinarstvu. Provodit će se dva glavna eksperimenta. U prvom će se ocjenjivati učinak proteinskih hidrolizata (PH) na rast sadnica masline i kemijski sastav njihovih tkiva. U drugom pokusu PH će se primijeniti na odraslim stablima maslina te će se pratiti njihov učinak na biljku kroz razlike u sastavu minerala te primarnih i sekundarnih metabolita u listu. Utvrdit će se i količina i kvaliteta maslinovog ulja. Nadalje, dubina prodiranja folijarno primijenjenih PH proučavat će se korištenjem molekularnog snimanja (prigušena totalna Fourier-transformirana infracrvena mikroskopija i masena spektrometrija sekundarnih molekularnih iona) kojima će se, nakon prikaza raspodjele minerala (mikročesticama inducirana emisija rendgenskoga zračenja) omogućiti utvrđivanje načina djelovanja PH. Struktura tako identificiranih PH bit će potvrđena usporedbom njihovih spektara nuklearne magnetske rezonancije i masenih spektara s onima sintetiziranih peptida. Na kraju će se ispitati učinak PH na bolest paunovog oka pri čemu će se utvrditi redistribucija elemenata oko simptomatskih nekrotičnih točaka. Projektni tim je visoko interdisciplinaran, a dobiveni će rezultati uvelike služiti biljnim biolozima, agronomima, poljoprivrednicima i nutricionistima. Projekt će omogućiti promicanje važnosti ekološki prihvatljivih preparata, opsežnu razmjenu znanja i omogućit će izobrazbu doktoranada i poslijedoktoranada koji će steći jedinstven skup vještina i imati pristup najsuvremenijim tehnologijama.]]></summary_hr><summary_en><![CDATA[A key challenge of modern agriculture is to increase productivity while reducing negative impacts on the environment and human health. Biostimulants are compounds which have a positive impact on plant fitness and resistance to pests without harming the environment and represent a green alternative to synthetic chemicals used in plant nutrition and protection. The aim of the project is to design a novel biostimulant originating from olive leaves, which are by-products of olive oil industry, and to use them in sustainable olive production. Particularly, two main experiments will be performed. In the first, protein hydrolysates’ (PHs) effect on the growth of olive seedlings and chemical composition of their tissues will be evaluated. In the second experiment PHs will be applied on mature olive trees and plants’ performance will be monitored through the differences in composition of minerals and primary and secondary metabolites and the amount and quality of olive oil will be determined. Furthermore, the penetration depth of foliarly applied PHs will be studied using molecular imaging (Attenuated Total Reflection-Fourier Transform Infrared microscopy and MeV-Secondary Ion Mass Spectrometry) which will, accompanied by mineral distribution imaging (micro-Particle-Induced X-ray Emission), enable resolving the mode-of-action of the PHs. Structure of so identified PHs will be confirmed by comparing their nuclear magnetic resonance and mass spectra with those of synthesized peptides. Finally, PHs effect on olive spot disease will be tested, where redistribution of elements around the symptomatic necrotic spots will be determined. The project will engage an interdisciplinary team to deliver knowledge required by plant biologists, agronomists, farmers and nutritionists. It will enable promote the importance of green tools, the extensive knowledge exchange and will allow training of PhD and postdoc students to obtain unique set of technical skills in cutting-edge technologies.]]></summary_en></project><project>
<id>15456</id><title_hr><![CDATA[Amplifikacija seizmičkoga gibanja tla uzrokovana topografskim efektima u Sjevernoj Hrvatskoj]]></title_hr><title_en><![CDATA[Seismic ground motion amplification induced by topographic irregularity in Northern Croatia]]></title_en><user_id>25746</user_id><user_firstLast_name>Davor Stanko</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-1296</code><acronim><![CDATA[SIGMATOPCRO]]></acronim><duration>31.12.2023 - 30.12.2027</duration><status>U tijeku</status><financ_value>180.238,06 eur</financ_value><scie_area_hr>Prirodne znanosti, Tehničke znanosti, </scie_area_hr><scie_area_en>Natural sciences, Technological sciences, </scie_area_en><scie_field_hr>Geofizika, Geologija, Geodezija, Rudarstvo, nafta i geološko inženjerstvo, </scie_field_hr><scie_field_en>Geophysics, Geology, Geodesy, Mining, petroleum and geological engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Geotehnički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Geotechnical Engineering]]></institution_en><team_members_id>27055, 3343, 865670, 865626, 3503, 25754, 865774, 865789, 13393, 867709, 867705, 867714, 40, 12912, 25881, 872910, </team_members_id><team_members_names><![CDATA[Dragana Dogančić, Hrvoje Meaški, Stjepan Strelec, Jasmin Jug Jug, Sanja Kovač, Radmila Salic Makreska, Kemal Edip, Olga-Joan Ktenidou, Marijan Kovačić, Vesna Poslončec-Petrić, Julijana Bojadjieva, Francesco Panzera, Snježana Markušić, Tomislav Fiket, Nikola Hrnčić, Laura Novak, ]]></team_members_names><keywords_hr><![CDATA[Sjeverna Hrvatska, Lokalizirana topografska oštećenja od potresa, Seizmičko gibanje tla, Topografska amplifikacija, Topografski hazard ]]></keywords_hr><keywords_en><![CDATA[North Croatia, Localized topographic earthquake damage patterns, Seismic ground motion, Topographic amplification, Topographic hazard]]></keywords_en><summary_hr><![CDATA[Nakon potresa u Zagrebu i Petrinji 2020., brojne crkve, kulturne i povijesne građevine (posebno izgrađene prije 1964.) diljem Sjeverne Hrvatske pretrpjele su štetu (oštećenje krovova, dimnjaka i neojačanih zidova). U usporedbi sa značajkama lokalnog tla (stijena, nizina, kotlina...), većina oštećenih sakralnih objekata i starijih građevina u Sjevernoj Hrvatskoj nastala je na istaknutim topografskim lokalitetima/uzvisinama. Amplifikacija seizmičkoga gibanja tla uzrokovana topografskim efektima može biti značajna na planinskim vrhovima, brežuljcima, padinama, grebenima i liticama te čak može biti jednaka ili jača u odnosu na amplifikaciju uzrokovanu rastresitim sedimentima. Na temelju makroseizmičkih opažanja lokaliziranih topografskih oštećenja od potresa, pet (5) najzanimljivijih topografskih lokaliteta u različitim područjima i epicentralnim zonama u Sjevernoj Hrvatskoj bit će odabrano za detaljna istraživanja. Metodološki pristupi istraživanja za procjenu amplifikacije seizmičkog gibanja tla uzrokovane topografskim nepravilnostima terena bit će podijeljeni u nekoliko istraživačkih ciljeva: makroseizmička opažanja praćena multidisciplinarnim terenskim istraživanjima, mjerenja mikroseizmičkog nemira i uspostava kontinuiranog seizmičkog monitoringa u svrhu analize topografskog modela, numeričkog modeliranja i statističkih procjena topografskog hazarda te GIS mapiranja. Važan aspekt projekta bit će kreiranje strukturirane baze podataka sa svim relevantnim informacijama, podacima, rezultatima te mikrozonacijskim kartama koja se može koristiti kao smjernica za buduća istraživanja i primjene. Potresi iz 2020. (Zagreb i Petrinja) uzrokovali su goleme ekonomske geoinženjerske efekte i povezane posljedice. Od velike je važnosti provesti ovakva jedinstvena i inovativna multidisciplinarna istraživanja koja će biti primjenjiva za prevenciju i smanjenju katastrofa potresa, te primjenu u projektima oporavka i rekonstrukcije u pogođenim stratigrafskim i topografskim područjima.]]></summary_hr><summary_en><![CDATA[Following the moderate Zagreb and strong Petrinja 2020 earthquakes, numerous churches, cultural and historical buildings (especially those built before 1964) throughout Northern Croatia reported damage. When compared to other sites (rock sites, lowlands, basins etc.), a sizable amount of recorded damage to churches and older buildings in Northern Croatia occurred on irregular topographic features. Seismic ground motion amplification induced by topographic irregularity can be significant on mountain tops, peaky hills, slopes, ridges, and cliff faces, and can be equally or more important than amplification caused by sedimentary stratigraphic effects. Based on macroseismic observations on localized topographical damage patterns from historical and recent earthquakes, five most interesting topographic localities in different areas and epicentral zones in Northern Croatia will be chosen for case-by-case studies. Research methodological approaches to estimate amplification of seismic ground motion induced by topographic irregularity will be divided into several research objectives: macroseismic observations followed by multidisciplinary field investigations, ambient noise measurements and continuous seismic monitoring for the purpose of topographic model analysis, numerical modelling, statistical topographic hazard assessments, and GIS mapping solutions. Major aspect of this project will be creation of open access database in which all relevant information’s, data, results and topographic microzonation maps will be structured that can be used as a guideline for future research studies and applications. Zagreb and Petrinja 2020 earthquakes caused massive economic geoengineering effects and associated consequences. It is of great significance to perform such unique and innovative multidisciplinary research to be applicable for the prevention and reduction of earthquake disasters as well for recovery and reconstruction in affected stratigraphic and topographic areas. ]]></summary_en></project><project>
<id>15460</id><title_hr><![CDATA[Interakcije između autonomnog i imunološkog sustava u multiploj sklerozi]]></title_hr><title_en><![CDATA[Interactions between autonomic and immune systems in multiple sclerosis]]></title_en><user_id>1081</user_id><user_firstLast_name>Mario Habek</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-8200</code><acronim><![CDATA[AUTIM-MS]]></acronim><duration>30.12.2023 - 29.12.2027</duration><status>U tijeku</status><financ_value>174.970,00 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Clinical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>5732, 4744, 4530, 3050, 17860, 29000, 24194, 4279, 869850, </team_members_id><team_members_names><![CDATA[Barbara Barun, Tereza  Gabelic, Ivan Adamec, Magdalena Krbot Skoric, Luka Crnošija, Anamari Junakovic, Željko Cvetić, Krešo Bendelja, Katy Sue Jerčinović, ]]></team_members_names><keywords_hr><![CDATA[multipla skleroza, autonomni živčani sustav, disautonomija, imunološki sustav, interakcija, ]]></keywords_hr><keywords_en><![CDATA[multiple sclerosis, autonomic nervous system, dysautonomia, immune system, interaction]]></keywords_en><summary_hr><![CDATA[Multipla skleroza (MS) je imunološki posredovana bolest središnjeg živčanog sustava (SŽS) koju karakterizira širok spektar kliničkih manifestacija. Upala i neurodegeneracija temeljni su patološki procesi u MS-u, potaknuti poremećenom aktivacijom imunološkog sustava. Pretpostavlja se da i simpatički i parasimpatički dio autonomnog živčanog sustava imaju utjecaj na upalne, protuupalne i neurodegenerativne puteve u MS-u. Ova će studija uključiti 100 osoba s prvim simptomom multiple skleroze. Za svakog sudionika jednom godišnje će se provoditi  klinička i MRI evaluacija te ishodi povezani s pacijentom (PRO), a u prvoj i četvrtoj godini provest će se testiranje autonomnog živčanog sustava i laboratorijska evaluacija (imunološke studije i protočna citometrijska analiza). Hipoteza ovog istraživanja je da osobe s MS-om i abnormalnostima autonomnog živčanog sustava u prvoj kliničkoj prezentaciji imaju aktivniji tijek bolesti, bez obzira na prisutnost drugih poznatih loših prognostičkih čimbenika. Glavni cilj ovog projekta je utvrditi utjecaj disautonomije na dva glavna aspekta MS-a: upalu i neurodegeneraciju. Rezultati istraživanja proširit će naše znanje i razumijevanje patofiziologije i dijagnostike MS-a, olakšati daljnja istraživanja na tu temu, a možda implicirati i nove terapijske pristupe. S obzirom na to da su oboljeli od MS-a (pwMS) većinom mlade osobe s očekivanim dugim životnim vijekom, rezultati ovog istraživanja mogli bi poboljšati naš dijagnostički i prognostički pristup MS-u i olakšati zadatke svim dionicima uključenim u proces.]]></summary_hr><summary_en><![CDATA[Multiple sclerosis (MS) is an immune mediated disease of the central nervous system (CNS) characterized by a wide spectrum of clinical manifestations. Inflammation and neurodegeneration are the underlying pathological processes in MS, triggered by an aberrant activation of the immune system. It can be speculated that both sympathetic and parasympathetic part of the autonomic nervous system function have the influence on inflammatory-anti-inflammatory and neurodegenerative pathways in MS. This study will include 100 consecutive people with the first symptom of multiple sclerosis, For each participant clinical and MRI evaluation and patient related outcomes (PRO) will be performed during every year of the project, and in the first and the fourth year the autonomic nervous system testing and laboratory evaluation (immunological studies and flow cytometric analysis) will be performed. The hypothesis of this research is that pwMS with autonomic nervous system abnormalities at first clinical presentation have more active disease course, regardless of the presence of other known poor prognostic factors. The principal aim of this project is to establish the influence of dysautonomia on two main aspects of MS: inflammation and neurodegeneration. Results of the study will expand our knowledge and understanding of the pathophysiology and diagnostics of MS, facilitate further research on the matter, and possibly imply new therapeutic approaches. Due to the fact that people with MS (pwMS) are mostly young individuals with a long-life expectancy, the results of this research could improve our diagnostic and prognostic approach to MS and facilitate the tasks for all stakeholders included in the process.]]></summary_en></project><project>
<id>15461</id><title_hr><![CDATA[Hrvatski prijedlozi u upotrebi – semantička i sintaktička analiza]]></title_hr><title_en><![CDATA[Croatian Prepositions in Use – Semantic and Syntactic Analysis]]></title_en><user_id>19110</user_id><user_firstLast_name>Ivana Matas Ivanković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-6867</code><acronim><![CDATA[HRPA]]></acronim><duration>31.12.2023 - 30.12.2027</duration><status>U tijeku</status><financ_value>68.938,52 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filologija, </scie_field_hr><scie_field_en>Philology, </scie_field_en><institution_hr><![CDATA[Institut za hrvatski jezik]]></institution_hr><institution_en><![CDATA[Institute of Croatian Language]]></institution_en><team_members_id>19128, 912, 2774, 19590, 19156, 8629, 872066, 25084, </team_members_id><team_members_names><![CDATA[Goranka Blagus Bartolec, Maja Glušac, Vedran Juričić, Daniela Katunar, Darko Matovac, Ljiljana Saric, Robert Sviben, Martina Pavić, ]]></team_members_names><keywords_hr><![CDATA[prijedlozi, baza, sintaksa, semantika, upravna riječ, zavisna riječ, kompleksne prijedložne konstrukcije, preneseno značenje]]></keywords_hr><keywords_en><![CDATA[prepositions, database, syntax, semantics, governing word, complement word, complex prepositional constructions, metaphorical meaning]]></keywords_en><summary_hr><![CDATA[Osnovni je cilj projekta istražiti semantička i sintaktička obilježja prijedloga ujednačenom metodologijom, što će se postići obradom primjera iz korpusa u bazi koja će se izraditi za potrebe projekta, te istraživanjima tako dobivenih podataka. Izradit će se relacijska baza s unaprijed definiranim poljima u koja će se unositi podatci otvorenog tipa i podatci s unaprijed zadanim vrijednostima. Izdvojit će se i istražiti kompleksne prijedložne konstrukcije u kojima su prijedlozi dio neodvojive višerječne jedinice kojoj se značenje određuje kao jedinstvenoj cjelini te će se napraviti repozitorij tih konstrukcija. Posebna pozornost posvetit će se istraživanjima doslovnog i prenesenog značenja u prijedložnoj upotrebi. Analiza konkretnih, apstraktnih i prenesenih značenja dijelova prijedložne sintagme omogućit će istraživanja metaforizacije i prenošenja konkretnih i dimenzionalnih značenja u sferu apstraktnog i nedimenzionalnog jer se metaforizacijom uobičajeno objašnjava preslikavanje relevantnoga dijela konfiguracije prostorne domene u neku apstraktniju domenu. Projekt će povezati i suvremena teorijska istraživanja prijedloga s primijenjenolingvističkim istraživanjima: prijedložne sintagme u učenju stranog jezika ponekad se čine kao rezultat nasumičnog odabira i stvaraju problem u učenju te će se iz baze izdvajati primjeri prikladni za poučavanje hrvatskoga kao stranog jezika na B razini na temelju kojih će se napraviti priručnik sa zadatcima za poučavanje prijedloga u nastavi hrvatskoga kao stranog jezika.]]></summary_hr><summary_en><![CDATA[The main goal of the project is to research the semantic and syntactic features of prepositions using a uniform methodology. The goal will be achieved by processing examples from the corpus in the database which will be created for the needs of the project and by researching the data obtained in the database. A relational database will be created with predefined fields in which open-type data and data with predefined values will be entered. Complex prepositional constructions in which the prepositions are part of an inseparable multi-word unit and whose meaning is determined as a whole will be isolated and researched, and a repository of these constructions will be created. Special attention will be paid to the research of literal and figurative meaning in prepositional use. The analysis of concrete, abstract and figurative meanings of parts of the prepositional phrase will enable research of metaphorization and transfer of concrete and dimensional meanings into the sphere of the abstract and non-dimensional because metaphorization usually explains the mapping of the spatial domain into a more abstract domain. The project will connect contemporary theoretical research on prepositions with applied linguistic research. Prepositional phrases in a foreign language sometimes seem to be the result of random selection and create a problem in learning. Examples suitable for teaching Croatian as a foreign language at the B level will be selected from the database, and a handbook with tasks for teaching prepositions in Croatian as a foreign language will be created.]]></summary_en></project><project>
<id>15463</id><title_hr><![CDATA[Dizajn i 3D-ispis mikroreaktorskih sustava za Industriju 4.0]]></title_hr><title_en><![CDATA[DesIgn aNd 3D printInG of micrOreactor systems for Industry 4.0]]></title_en><user_id>5338</user_id><user_firstLast_name>Domagoj Vrsaljko</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-8004</code><acronim><![CDATA[INDIGO]]></acronim><duration>15.12.2023 - 14.12.2027</duration><status>U tijeku</status><financ_value>199.084,21 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Temeljne tehničke znanosti, Kemijsko inženjerstvo, Strojarstvo, Interdisciplinarne tehničke znanosti, </scie_field_hr><scie_field_en>Basic engineering sciences, Chemical engineering, Mechnical engineering, Interdisciplinary technological sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet kemijskog inženjerstva i tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Chemical Engineering and Technology]]></institution_en><team_members_id>19529, 20534, 25655, 1529, 18926, 24859, 25297, 869553, 872891, </team_members_id><team_members_names><![CDATA[Boris Zimmermann, Guyon Cédric, Volha Shapaval, Ivana Grčić, Kristina Zagajski Kučan, Petar Kassal, Zvonimir Matusinović, Elizabeta Forjan, Lara Štorga, ]]></team_members_names><keywords_hr><![CDATA[procesno inženjerstvo, industrijski dizajn, 3D-ispis, mikroreaktorski sustavi, Industrija 4.0, inženjerstvo materijala]]></keywords_hr><keywords_en><![CDATA[process engineering, industrial design, 3D printing, microreactor systems, Industry 4.0, materials engineering]]></keywords_en><summary_hr><![CDATA[Tehnologija 3D-ispisa je relativno jeftina, automatizirana i prilagodljiva metoda koja omogućuje sintetskim laboratorijima i malim tvrtkama da dobiju pristup alatima kemijskog inženjerstva koji se obično koriste samo u velikim industrijskim okruženjima.Ovaj projektni prijedlog predstavlja nastavak istraživanja provedenog u našem prethodnom projektu HRZZ-a „Development of materials for 3D printing of microreactors“ (3Dmicroreactors). Projekt 3Dmicroreactors je riješio mnoge probleme i stvorio nove zanimljive izazove, koji su identificirani kao šest ciljeva koje ćemo rješiti ovim projektom.Cilj projekta INDIGO je istražiti i razviti metode 3D-ispisa za proizvodnju kompliciranih mikrosustava kao što su mikroreaktori i separatori za upotrebu u protočnoj kemiji.Kako bi pravilno funkcionirali, kontinuirani kemijski procesi moraju se nadzirati on-line in situ postavljenim senzorima. Budući da je većina kemijskih procesa šaržni proces, analize se obično provode nakon završetka procesa. Uz sve veći broj reakcija koje se izvode kao protočna kemija, on-line in situ mjerenja postaju sve zanimljivija znanstvenicima. Novi sustavi s integriranim sondama za on-line in situ mjerenja bit će dizajnirani i 3D-ispisani.Jedan od tipičnih problema s in situ mjerenjima je zaprljanje sonde senzora zbog prianjanja reaktanata i/ili produkata reakcije. Kako bi se riješio problem onečišćenja i poboljšala kontrola reakcije, testirat će se novi dizajni reaktora i modifikacije površine.]]></summary_hr><summary_en><![CDATA[3D printing technology is a relatively cheap, automated, and customizable method that allows synthetic laboratories and small businesses to gain access to chemical engineering tools that are typically only used in large-scale industrial settings.This project proposal represents a continuation of research conducted in our previous HRZZ project, &#39;&#39;Development of Materials for 3D Printing of Microreactors&#39;&#39; (3Dmicroreactors). 3Dmicroreactors solved many problems and created new interesting challenges, which were identified as six objectives we will solve in this project.The aim of the project, INDIGO, is to research and develop 3D printing methods for manufacturing complicated microsystems such as microreactors and separators for use in flow chemistry.To function properly, continuous chemical processes must be monitored online by in situ positioned sensors. Since most chemical processes are batch processes, analyses are usually performed after the process is completed. With the increasing number of reactions performed as flow chemistry, the on-line in situ measurements are becoming more and more interesting for scientists. New systems with integrated probes for on-line in situ measurements will be designed and 3D printed.One of the typical problems with in situ measurements is fouling of the sensor probe due to adhesions of reactants and/or reaction products. To solve the problem of fouling and improve reaction control, new reactor designs and surface modifications will be tested.]]></summary_en></project><project>
<id>15464</id><title_hr><![CDATA[Proizvodna mreža: topologija, promjena i transmisija]]></title_hr><title_en><![CDATA[Production network: topology, change and transmission]]></title_en><user_id>27231</user_id><user_firstLast_name>Stjepan Srhoj</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-8560</code><acronim><![CDATA[PRODNETWORK]]></acronim><duration>31.12.2023 - 30.12.2027</duration><status>U tijeku</status><financ_value>113.469,78 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, </scie_field_hr><scie_field_en>Economy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Ekonomski fakultet]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Economics, Business and Tourism]]></institution_en><team_members_id>29382, 19176, 866433, 866498, 866559, 872392, 4313, 872405, 872417, 25753, </team_members_id><team_members_names><![CDATA[Dario Miočević, Bruno Ćorić, Scott Stern, Alex Coad, Janette Walde, Melko Dragojević, Vinko Zaninović, Ebehireme Iyoha, Ivan Romic, Ante Toni Vrdoljak, ]]></team_members_names><keywords_hr><![CDATA[ponašanje poduzeća, rast poduzeća, proizvodna mreža, evaluacija, potpore, javna nabava ]]></keywords_hr><keywords_en><![CDATA[firm behaviour, firm growth, production network, public grants, public procurement]]></keywords_en><summary_hr><![CDATA[Prijedlog projekta PRODNETWORK razvijen je na temelju napretka ostvarenog u projektu HrZZ-a „Politike za povećanje otpornosti: Istraživanje uloge javnih potpora (CROREP)“ istog glavnog istraživača. Visoko rangirani donositelji  politika, kao i uvidi iz projekta CROREP, identificirali su nedostatke u nacionalnom i međunarodnom znanju o tome kako proizvodne mreže funkcioniraju, njihovoj topologiji, promjenama i prijenosu. Kako bi se zatvorio ovaj jaz u znanju, projekt PRODNETWORK podijeljen je u pet studija koje su zajedno usmjerene na analizu važnosti proizvodne mreže, njezine promjene i prijenosa. U ovom projektnom prijedlogu, proizvodna mreža definirana je kao trgovačka mreža između poduzeća ili međunarodna trgovačka mreža između zemalja i sektora. Studija 1 mapira proizvodnu mrežu u Republici Hrvatskoj, izračunava mjere za identifikaciju sistemski važnih poduzeća  i opisuje promjene proizvodne mreže tijekom egzogenih napada (tj. pandemije, šokova u energetskoj mješavini). Studija 2 uzročno procjenjuje izravne, nizvodne i uzvodne učinke ugovora o javnoj nabavi na razini poduzeća. Studija 3 uzročno procjenjuje izravne, nizvodne i uzvodne učinke javnih potpora na razini poduzeća. Studija 4 istražuje kada se moć u vezi kupac-dobavljač manifestira negativno, a kada pozitivno na organizacijske ishode. Studija 5 procjenjuje razlikuje li se učinak energetskih šokova na ekonomski rast s obzirom na strukturu proizvodne mreže. Rezultati ovog projekta bit će objavljeni u vodećim ekonomskim ili područnim ekonomskim časopisima.]]></summary_hr><summary_en><![CDATA[PRODNETWORK project proposal was developed from progress done in the HrZZ project “Resilience Enhancing Policies: Exploring the Role of Public Grants (CROREP)“ of the same principal investigator. Highly ranked policymakers as well as insights from the CROREP project have identified gaps in national and international knowledge about how production networks work, their topology, change and transmission. To close this knowledge gap, the PRODNETWORK project is divided into five studies that collectively focus on analysing the importance of production network, its change and transmission. In this project proposal, the production network is defined as the trade network between firms, or the international trade network between countries and sectors. Study 1 maps the production network in the Republic of Croatia, calculates measures to identify systemically important firms and describe changes of production network during exogenous attacks (i.e. pandemic, energy mix shocks). Study 2 causally estimates direct, downstream and upstream effects of public procurement contracts at the micro-level. Study 3 causally estimates direct, downstream and upstream effects of public grants at the micro-level. Study 4 investigates when power in customer-supplier link manifests on organizational outcomes negatively and when positively. Study 5 estimates how the effect of energy shocks on output differs with respect to the production network structure. Results of this project will be published in leading economics or field economics journals.]]></summary_en></project><project>
<id>15465</id><title_hr><![CDATA[Sinteza mehatroničkog sustava aktivnog ovjesa sjedala autonomnog vozila]]></title_hr><title_en><![CDATA[Design of autonomous vehicle active seat suspension mechatronic system ]]></title_en><user_id>11149</user_id><user_firstLast_name>Joško Deur</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-2894</code><acronim><![CDATA[DAVAS]]></acronim><duration>31.12.2023 - 30.12.2027</duration><status>U tijeku</status><financ_value>135.498,04 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, Elektrotehnika, </scie_field_hr><scie_field_en>Mechnical engineering, Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>12623, 866099, 12618, 866190, 866098, 866142, 25393, 869641, 868745, </team_members_id><team_members_names><![CDATA[Mario Hrgetić, Matija Hoić, Branimir Škugor, Nenad Kranjčević, Krunoslav Haramina, Dominik Birt, Ivan Cvok, Ivan Ruškan, Ivo Grđan, ]]></team_members_names><keywords_hr><![CDATA[Aktivni ovjes, sjedalo, mehatronika, autonomno vozilo, sinteza, modeliranje, upravljanje, eksperimentalno ispitivanje]]></keywords_hr><keywords_en><![CDATA[Active suspension, seat, mechatronics, autonomous vehicle, design, modeling, control, experimental testing]]></keywords_en><summary_hr><![CDATA[Projekt se bavi razvojem mehatroničkog sustava aktivnog ovjesa sjedala autonomnog vozila, uključujući sintezu modelskog prediktivnog sustava upravljanja. Konačni cilj je poboljšanje udobnosti vožnje i kvalitete obavljanja zadataka tijekom autonomne vožnje, poput čitanja i pisanja/tipkanja te crtanja. Projekt je organiziran oko dvije glavne teme. Prva tema uključuje istraživanje i razvoj mehatroničkog sklopa aktivnog ovjesa sjedala u dvije komplementarne varijante, uključujući sintezu podređenog sustava upravljanja aktivnim ovjesom za precizno generiranje vertikalne sile te tehno-ekonomsku analizu primjene realiziranih rješenja u autonomnim i drugim vozilima. Za potrebe sinteze podređenog sustava upravljanja postavit će se matematički i simulacijski model mehatroničkog sklopa, koji će se eksperimentalno validirati zajedno sa strategijom upravljanja. Druga tema odnosi se na sintezu nadređene modelsko-prediktivne strategije upravljanja aktivnim ovjesom sjedala, koja će omogućiti iskorištenje unaprijedne informacije o profilu podloge i varijablama stanja šasije. Previđena je sinteza linearnog i nelinearnog modelskog prediktivnog upravljanja i to u inačicama centraliziranog i praktičnijeg raspregnutog upravljanja aktivnim ovjesom sjedala i šasije. Razvijene upravljačke strategije provjerit će se eksperimentalno na postavu za generiranje vibracija autosjedala, u koji će se ugraditi razvijeni mehatronički sklop aktivnog ovjesa. Konačno, provest će se laboratorijsko ispitivanje udobnosti vožnje i kvalitete obavljanja radnih zadataka na širokom skupu ispitanika, kako bi se eksperimentalno potvrdila uspješnost razvijenog sustava te utvrdile smjernice za njegovu primjenu u autonomnim vozilima. Projekt okuplja multidisciplinarnu istraživačku skupinu koja uključuje istraživače s područja strojarstva, elektrotehnike i računarstva te ima višegodišnje zajedničko iskustvo u provođenju sličnih projekata.]]></summary_hr><summary_en><![CDATA[The project deals with design of an active seat suspension mechatronic system for autonomous vehicles, including a model predictive control strategy. The final aim is to improve the ride comfort and task execution performance during autonomous driving, where the tasks include reading, writing/typing, and drawing. The project is organized around two research themes. The first theme concerns research and development of two complementary variants of the active seat suspension mechatronic hardware/unit, including a corresponding low-level control system aimed at precise control of vertical force, as well as an techno-economic analysis towards application of the designed mechatronic unit in autonomous and other vehicles. Mathematical and simulation models of the mechatronic unit will be derived for the purpose of low-level control system design, and they will be experimentally verified together with the control strategy. The second theme relates to the design of high-level model predictive control system for active seat suspension, which will employ road profile preview and chassis suspension state feedback. Both linear and nonlinear model predictive control system designs, given in centralized and more practical, decoupled active seat/chassis suspension control variants, will be considered. The designed high-level control strategies will be experimentally verified on a shaker rig, into which the developed active seat suspension mechatronic unit will be integrated. Finally, the test rig-based ride comfort and task execution evaluation will be performed for a large group of examinees, in order to experimentally assess the designed mechatronic system and provide recommendations for its application in autonomous vehicles. The project brings together a multidisciplinary research group, which includes researchers from the areas of mechanical engineering, electrical engineering, and computing, and has a multi-year joint experience in execution of similar projects.]]></summary_en></project><project>
<id>15467</id><title_hr><![CDATA[Uloga međustaničnog prijenosa mitohondrija u širenju senescencije u tkivima]]></title_hr><title_en><![CDATA[The role of cell-to-cell mitochondrial transfer in spreading senescence in tissues]]></title_en><user_id>1396</user_id><user_firstLast_name>Ivica Rubelj</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-4583</code><acronim><![CDATA[MiTranSen]]></acronim><duration>18.12.2023 - 17.12.2027</duration><status>U tijeku</status><financ_value>109.496,32 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>19039, 570, 3713, 3095, 865829, 3527, 866216, 23714, 420, 28663, </team_members_id><team_members_names><![CDATA[Lucia Nanić, Miljenko Huzak, Anamaria Brozović, Martina Deželjin, Sandrine Dubrac, Ranko Stojković, Anita Breški, Michael Bader, Ana Tadijan, Ivana Pavičić, ]]></team_members_names><keywords_hr><![CDATA[Senescencija, mitohondriji, starenje, SASP, 3D kultura, mitofagija]]></keywords_hr><keywords_en><![CDATA[Senescence, mitochondria, aging, SASP, 3D culture, mitophagy]]></keywords_en><summary_hr><![CDATA[Nakupljanje senescentnih stanica u tkivima je glavni uzrok starenja i bolesti povezanih sa starenjem. Senescencija je, u normalnim uvjetima, primarno posljedica skraćivanja telomera što daje signal dvolančanog loma DNA i permanentnog zaustavljanja staničnih dioba. Senescentne stanice se mijenjaju morfološki, fiziološki, gube svoju primarnu funkciju i profil genetičke ekspresije i sekrecije te kao takve negativno utječu na okolne zdrave stanice u kojima induciraju sekundarnu senescenciju. Ključnu ulogu u stvaranju senescentnog fenotipa, uključujući sekreciju igraju mitohondriji. Stanice iz kojih su mitohondriji eliminirani ulaze u senescenciju, ali ne razvijaju senescentni sekretorni fenotip. Proces širenja senescencije na okolne zdrave stanice se do danas gotovo u potpunosti pripisivao utjecaju topivih komponenti senescentne sekrecije. Najnovija istraživanja daju naslutiti da senescentne stanice u kulturi nakon što akumuliraju disfunkcionalne mitohondrije postaju vrlo agresivne u prenošenju svojih mitohondrija okolnim zdravim stanicama gdje se odvija transmitofagija. Dok je prijenos mitohondrija kod nekrotičnih i tumorskih stanica dobro poznat, potpuno je neistražen kod senescencije, a pogotovo ne u fenomenu širenja senescencije u 3D tkivima i in vivo. Naši preliminarni rezultati pokazuju da je transfer mitohondrija između senescentnih i mladih/proliferirajućih stanica intenzivan. Stoga ćemo u ovom projektu istražiti utjecaj međustaničnog prijenosa mitohondrija u širenju senescencije u tkivima. Koristit će se kombinacije kožnih stanica u kulturi, 3D kulture punog profila kože te in vivo na modelu štakora Fischer 344. Kako je zamijećeno da se senescentne stanice u tkivima in vivo pojavljuju u skupinama, a ne u jednoličnom raspršenju, projekt će testirati hipotezu da je najutjecajniji mehanizam širenja senescencije u tkivima u procesu starenja upravo transfer nefunkcionalnih mitohondrija iz senescentnih stanica u okolne mlade stanice, uključujući i matične stanice.]]></summary_hr><summary_en><![CDATA[Accumulation of senescent cells in tissues is the main cause of aging and age-related diseases. Senescence, under normal conditions, is primarily a consequence of telomere shortening, which signals a double-stranded DNA break and permanent cessation of cell division. Senescent cells change in morphology and physiology, lose their primary function and profile of gene expression and secretion, and as such negatively affect the surrounding healthy cells in which they induce secondary senescence. Mitochondria play a key role in creating the senescent phenotype, including secretion. Cells with eliminated mitochondria enter senescence, but do not develop a senescent secretory phenotype. The process of spreading senescence to the surrounding cells was almost entirely attributed to the influence of the soluble components of the senescent secretion. The latest research suggests that senescent cells in culture, after accumulating dysfunctional mitochondria, become very aggressive in transferring their mitochondria to the surrounding healthy cells where transmitophagy takes place. While mitochondrial transfer in necrotic and tumor cells is well known, it is completely unexplored in aging and senescence, and especially not in 3D tissues cultures and in vivo. Our preliminary results indicate that mitochondrial transfer between senescent and young/proliferating cells is frequent. In this project, we will investigate the influence of intercellular transfer of mitochondria in spreading of senescence among cells in few systems; combinations of skin cells in culture, 3D culture of full skin profile and in vivo in the Fischer 344 rat model. As it has been observed that senescent cells in tissues in vivo appear in groups and not uniform, the project will test the hypothesis that the most influential mechanism of spreading senescence in tissues in the aging process is the transfer of dysfunctional mitochondria from senescent cells to the surrounding young cells, including stem cells.]]></summary_en></project><project>
<id>15469</id><title_hr><![CDATA[Razvoj polimera s otiskom molekula za primjenu u analizi farmaceutika i tijekom naprednih postupaka obrade voda]]></title_hr><title_en><![CDATA[Development of molecularly imprinted polymers for use in analysis of pharmaceuticals and during advanced water treatment processes]]></title_en><user_id>4391</user_id><user_firstLast_name>Dragana Mutavdžić Pavlović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-4400</code><acronim><![CDATA[MIPdePharma]]></acronim><duration>15.12.2023 - 14.12.2027</duration><status>U tijeku</status><financ_value>194.438,92 eur</financ_value><scie_area_hr>Prirodne znanosti, Tehničke znanosti, </scie_area_hr><scie_area_en>Natural sciences, Technological sciences, </scie_area_en><scie_field_hr>Kemija, Kemijsko inženjerstvo, Temeljne tehničke znanosti, Interdisciplinarne prirodne znanosti, </scie_field_hr><scie_field_en>Chemistry, Chemical engineering, Basic engineering sciences, Interdisciplinary natural sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet kemijskog inženjerstva i tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Chemical Engineering and Technology]]></institution_en><team_members_id>1414, 900, 12861, 3680, 27330, 26152, 27497, 23212, 868126, 868037, 867625, 872909, 872980, </team_members_id><team_members_names><![CDATA[Sandra Babić, Lidija Ćurković, Davor Ljubas, Mira Petrovic, Mario Lovrić, Dejan Milenković, Kristina Tolić Čop, Ivana Gabelica, Debora Briševac, Katarina Marija Drmić, David Visentin, Leona Čakić, Paola Grobenski, ]]></team_members_names><keywords_hr><![CDATA[polimeri s otiskom molekule, farmaceutici, računalne simulacije, priprava uzorka, sorpcija, fotokataliza]]></keywords_hr><keywords_en><![CDATA[molecularly imprinted polymers, pharmaceuticals, computational simulation, sample preparation, sorption, photocatalysis]]></keywords_en><summary_hr><![CDATA[Farmaceutici se kontinuirano unose u okoliš, a njihova potrošnja bilježi uzlaznu putanju zbog pojave novih bolesti, ali i broja oboljenja. Svi oni prije ili poslije završe u vodama tako da kontinuirano treba raditi na poboljšanju postojećih te razvoju novih analitičkih protokola za njihovo određivanje. Zbog velikog broja različitih komponenti koji se mogu naći u realnim uzorcima posebice u situacijama kada u uzorku imamo spojeve različite polarnosti sam postupak pripreme uzorka za analizu primjenom komercijalnih sorbensa postaje nedostatan. S druge strane problem se javlja i tijekom različitih postupaka obrade vode jer je velika većina organskih zagađivala pa tako i farmaceutika postojana u okolišu i teško razgradljiva. Projekt MIPdePharma će se baviti pripremom polimernih sorbensa s otiskom (MIP) ciljane molekule na više različitih načina u ispitivanom području primjene (priprava uzorka, sorpcija i fotokataliza), a sve s ciljem rješavanja prethodno navedenih problema. To će se postići provedbom velikog broja eksperimenata, pregledom literature te na osnovu fizikalno-kemijskih karakteristika ciljane molekule kroz sinergiju između iskusnih istraživača iz područja analitičke kemije, znanosti o okolišu, kemije materijala i računalne kemije. Primjena računalne kemije, uključivat će predviđanje najpovoljnije strukture istraživanih sustava koji bi trebali utjecati na smjer daljnjih eksperimenata, a koji će značajno skratiti postupak njihove pripreme te smanjiti primjenu velike količine standardne tvari ciljane molekule farmaceutika potrebnog za molekularno utiskivanje. Na kraju će se za sve pripremljene sorbense ispitati ostvarena učinkovitost. Kod postupka pripreme uzorka ona će se usporediti s učinkovitošću na komercijalno dostupnim sorbensima, dok će se u slučaju razvoja inovativnih tehnologija obrade otpadnih voda utvrditi i energetska učinkovitost svakog pojedinačnog procesa.]]></summary_hr><summary_en><![CDATA[Drugs are constantly being introduced into the environment, and their consumption is constantly increasing due to the emergence of new diseases and number of diseases. They all end up in the water, so it is necessary to work on improving existing and developing new analytical protocols for their determination. Due to the large number of components that can be found in real samples, especially in situations where compounds of different polarity are present in the sample, the sample preparation for analysis with commercial sorbents is insufficient. On the other hand, the problem also occurs in various water treatment processes, since the vast majority of organic pollutants, including pharmaceuticals, are persistent and difficult to degrade in the environment.The MIPdePharma project will address the preparation of molecularly imprinted polymer (MIP) with target molecule in different ways in the studied application area (sample preparation, sorption and photocatalysis), all with the aim of solving the above problems. This will be achieved by performing a large number of experiments, reviewing the literature and based on the physicochemical properties of the target molecule through the synergy between experienced researchers in the fields of analytical chemistry, environmental science, materials chemistry and computational chemistry. The application of computational chemistry will involve the prediction of the most favorable structure of the studied systems, which should influence the direction of further experiments, and will significantly shorten the process of their preparation and reduce the use of a large amount of the standard substance of the pharmaceutical target required for MIP. At the end, the obtained MIP efficiency will be tested. For sample preparation, it will be compared with the efficiency of commercially sorbents, while for the development of innovative wastewater treatment technologies, the energy efficiency of each process will be determined.]]></summary_en></project><project>
<id>15470</id><title_hr><![CDATA[Istraživanje i primjena novih fazno promjenjivih kompozita za regulaciju radne temperature silicijskih fotonaponskih panela]]></title_hr><title_en><![CDATA[Investigation and application of novel phase change composites for temperature regulation of silicon photovoltaic panels]]></title_en><user_id>860</user_id><user_firstLast_name>Sandro Nižetić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-3971</code><acronim><![CDATA[PCM-PV-COOL]]></acronim><duration>18.12.2023 - 17.12.2027</duration><status>U tijeku</status><financ_value>111.088,99 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, Temeljne tehničke znanosti, </scie_field_hr><scie_field_en>Mechnical engineering, Basic engineering sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Fakultet elektrotehnike, strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Electrical Engineering, Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>2623, 23797, 6053, 25442, 1163, 865584, 867627, </team_members_id><team_members_names><![CDATA[Duje Čoko, Muslum Arici, Marija Ćosić, Mišo Jurčević, Miće Jakić, Jelena Bošnjak Hordov, Ivan Čorić, ]]></team_members_names><keywords_hr><![CDATA[fazno promjenjivi materijali,kompoziti,fotonaponske tehnologije,obnovljivi izvori energije,energetska učinkovitost]]></keywords_hr><keywords_en><![CDATA[phase change materials,composites,photovoltaic technologies, renewable energy sources, energy efficiency]]></keywords_en><summary_hr><![CDATA[Predloženi znanstveni projekt bavi se razvojem te primjenom novih fazno promjenjivih materijala (FPM), odnosno FPM-kompozita (FPK) kod obnovljivh izvora energije, tj., silicijskih fotonaponskih (FN) panela, a u svrhu reguliranja radne temperature FN panela. Istraživanje obuhvaća razvoj novih FPK-a kao kombinaciju različitih komercijalno dostupnih FPM-a te FPM-a životinjskog podrijetla kao i različitih otpadnih materijala. Istraživanje uključuje izradu uzoraka te ispitivanje toplinskih svojstava novopredloženih FPK-a (toplinska vodljivost, specifični toplinski kapacitet te latentna toplina). Predviđena je realizacija eksperimentalne aparature za provedbu cikličkih ispitivanja, a u cilju ispitivanja toplinskih svojstava nakon određenog broja ciklusa. Novo razvijeni FPK-i primjenit će se za slučaj pasivnog hlađenja silicijskog fotonaponskog panela, a u svrhu poboljšanja performansi te trajnosti fotonaponskih panela. Predviđena je izrada eksperimentalnog postava kao i provedba mjerenja u okolnostima mediteranske klime. Predloženo istraživanje ima širi značaj obzirom da se istraženi FPK-i mogu potencijalno primjenjivati kod različitih sustava skladištenja toplinske energije ili, primjerice, kod zahtjeva toplinske regulacije sustava ili komponenti u raziličitim inženjerskim primjenama. ]]></summary_hr><summary_en><![CDATA[Proposed research project is focused on development and application of the novel phase change materials (PCM), i.e. PCM-composites (PCCs) for renewable energy sources applications, i.e. for regulating operating temperature of silicon photovoltaic (PV) panels. Investigation covers development of novel PCCs as a combination of commercially available PCMs and PCMs of animal origin along with with various waste materials. Investigation includes experimental analysis of thermal properties for novel PCCs, such as thermal conductivity, specific heat capacity and latent heat. The cyclic investigations of novel PCCs are also planned in the proposed research, where specific experimental setup for cycling tests would be developed in order to determine behaviour of novel PCCs after specific number of cycling tests. New PCCs would be applied in the case of the passively cooled PV panel with main goal to improve PV panel performance as well as lifetime. The experimental approach for passive cooling of the PV panel would be developed and measurements will be conducted in the mediterranean climate circumstances. Proposed investigation has got wide potential benefit since novel developed PCCs can be  also implemented in the case of different thermal energy storage applications or in the case of thermal regulation of systems, i.e. components in various engineering requests.  ]]></summary_en></project><project>
<id>15471</id><title_hr><![CDATA[Specifičnosti razvoja kortikalnih interneurona u prefrontalnom korteksu čovjeka tijekom fetalnog razvoja i prve godine života – uloga u nastanku shizofrenije i autizma]]></title_hr><title_en><![CDATA[Uniqueness in development of interneurons in human prefrontal cortex during fetal life and first postnatal year – implications in pathogenesis of schizophrenia and autism]]></title_en><user_id>2567</user_id><user_firstLast_name>Zdravko Petanjek</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-8493</code><acronim><![CDATA[DEVINTERPFC]]></acronim><duration>31.12.2023 - 30.12.2027</duration><status>U tijeku</status><financ_value>194.000,00 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>6256, 2549, 4699, 4770, 12673, 26092, 18991, 17812, 29245, 865647, 866524, 861566, 23501, 866245, 867707, 869884, 866385, </team_members_id><team_members_names><![CDATA[Nataša Jovanov Milošević, Ana Hladnik, Davor Mayer, Marija Baković, Dora Sedmak, Ivan Banovac, Branka Hrvoj Mihic, Vinka Knezović, Andrea Blažević, Matija Vid Prkačin, Maura Zanze Beader, Goran Ivkić, Tomislav Ćaleta, Martina Bračun, Marina Čavka, Joško Bilandžić, Tin Luka Petanjek, ]]></team_members_names><keywords_hr><![CDATA[migracija, GABA, kora velikoga mozga, perinatalno razdoblje, nedonošče]]></keywords_hr><keywords_en><![CDATA[migration, GABA, cerebral cortex, perinatal period, prematurus]]></keywords_en><summary_hr><![CDATA[Većina neuroloških i psihijatrijskih poremećaja koji uključuju patologiju moždane kore ima u svojoj podlozi određenu razinu dezorganizacije GABA-ergičke mreže. Ona je najčešće posljedica odstupanja nastalih tijekom razvoja. Jedna od specifičnosti razvoja moždane kore u čovjeka je da se GABA-ergički neuroni intenzivno stvaraju i kroz posljednje tromjesečje trudnoće te nekoliko mjeseci nakon rođenja. Stoga je cilj ovog istraživanja identificirati zone proliferacije i puteve migracije kortikalnih neurona u nedonoščeta i dojenčeta.Rezovi postmortalnog tkiva čovjeka i majmuna obradit će se koristeći imunohistokemijske i RNAscope metode na proliferativne, migratorne i biljege GABA-ergičkih neurona. RNAscope je nova metoda in situ hibridizacije, tehnički pristupačnija i s većom pouzdanosti u detekciji signala, a omogućava i paralelnu detekciju imunohistokemijskog signala. Obrađeni rezovi sustavno će se morfometrijski analizirati tijekom ključnih fetalnih stadija i tijekom prve godine života te će se utvrditi raspodjela stanica koje izražavaju biljege proliferacije i migracije, kao i biljege GABA-ergičkih neurona. Koristeći ove podatke izradit će se 3D model puteva migracije kortikalnih neurona u nedonoščadi i dojenčadi.U okviru ovog projekta provest će se preliminarna analiza kako bi se u nedonoščadi i dojenčadi metodama slikovnog prikaza (UZV, MRI) pokušale identificirati zone migracije GABA-ergičkih neurona opisane na histološkim rezovima. Također, u okviru projekta predviđeno je stvaranje mreže unutar Europskog istraživačkog prostora (ERA) s grupama koje imaju ekspertizu i koje su usmjerene na istraživanje razvoja ljudskog mozga ili primjenjuju eksperimentalne metode istraživanja morfoloških i funkcionalnih svojstava identificiranih populacija GABA-ergičkih neurona. Ovaj aspekt posebno je važan za daljnji razvoj karijera mlađih istraživača uključenih u rad na projektu.]]></summary_hr><summary_en><![CDATA[A certain level of disorganization of the GABAergic network underlies most neurological and psychiatric disorders that involve pathology of the cerebral cortex. This disorganization is most often the result of abnormalities that occurred during development.One of the specifics of the development of the cerebral cortex in humans is that GABAergic neurons are intensively created during the last trimester of pregnancy and several months after birth.Therefore, the aim of this research is to identify the proliferation zones and migration paths of cortical neurons in infants and premature infants.Sections of postmortem human and monkey tissue will be processed using immunohistochemical and RNAscope methods for proliferative, migratory and GABAergic markers. RNAscope is a new method of in situ hybridization, more accessible and more reliable in signal detection, and it also enables parallel detection of immunohistochemical signals.The processed sections will be systematically morphometrically analyzed during the key fetal stages and during the first year of life. The distribution of cells expressing proliferative, migratory and GABAergic markers will be determined. Using this data, a 3D model of the migration paths of cortical neurons in infants and premature infants will be created.In the framework of this project, a preliminary analysis will be carried out in order to attempt to identify the migration zones of GABAergic neurons described on histological sections in infants and premature infants using imaging methods (US, MR).The project envisions the creation of a network within the European Research Area (ERA) with groups that have expertise and are focused on researching the development of the human brain or applying experimental methods of researching the morphological and functional properties of identified populations of GABAergic neurons. This aspect is particularly important for the further professional development of younger researchers involved in the project.]]></summary_en></project><project>
<id>15482</id><title_hr><![CDATA[Modeli naručiteljstva. Naručitelji, umjetnici i publika u Zagrebu u 17. i dugom 18. stoljeću]]></title_hr><title_en><![CDATA[Patterns of Patronage. Commissioners, Artists and Public in Zagreb in 17th and long 18th century ]]></title_en><user_id>871</user_id><user_firstLast_name>Dubravka Botica</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-3190</code><acronim><![CDATA[MODENAR]]></acronim><duration>18.12.2023 - 17.12.2027</duration><status>U tijeku</status><financ_value>104.292,14 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Povijest umjetnosti, Povijest, </scie_field_hr><scie_field_en>Art history, History, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>23307, 4586, 735, 29518, 6667, 20064, 764, 4663, 869918, </team_members_id><team_members_names><![CDATA[Josipa Alviž, Petra Batelja Majić, Sanja Cvetnić, Valentina Janković, Matej Klemenčič, Petar Puhmajer, Danko Šourek, Maja Žvorc, Zeynep Oguz Kursar, ]]></team_members_names><keywords_hr><![CDATA[naručitelji, umjetnici, Zagreb, rani novi vijek, mreže]]></keywords_hr><keywords_en><![CDATA[commissioners, artists, Zagreb, early modern age, networks]]></keywords_en><summary_hr><![CDATA[Razdoblje 17. i dugog 18. st., od dolaska isusovaca 1606. do Bečkog kongresa, obilježeno je porastom umjetničke djelatnosti u Zagrebu i okolici. Naručiteljskom djelatnošću u razmatranom razdoblju uvelike se mijenja lice grada koji postaje umjetničko i kulturno središte, povezano sa susjednim regijama srednjoeuropskog prostora. Upravo će veze s okruženjem, kojeg ne promatramo samo geografski nego kao gusto umrežen pluralistički kulturni i umjetnički prostor, biti ključne u formiranju umjetničkih narudžbi u Zagrebu. U fokusu istraživanja projekta su dinamični procesi i društvene i kulturne okolnosti koji utječu na narudžbe umjetničkih djela, na odnos umjetnika i naručitelja te na sudbinu i konzumente umjetničkih dijela. Cilj projekta je novim pristupom temi naručiteljstva istražiti široki raspon različitih oblika naručiteljske prakse u društvenom i kulturnom kontekstu njihova nastanka. Korpus istraživanja su umjetnička djela koja su mjestom nastanka, narudžbe, porijekla umjetnika ili naručitelja vezana za Zagreb, case-study istraživanjem će se ustanoviti modeli naručiteljstva i razmotriti u odnosu na druge srodne sredine. U gradu koji postaje središte okupljanja i konzumiranja kulturnih sadržaja visokih društvenih slojeva, istraživat će se isprepletena heterogena struktura umjetnika i naručitelja, s naglaskom na pojedincima iz redova društvenih elita (plemstvo, crkvene i vojne elite) ulozi skupina (crkveni redovi) kao i ulozi različitih jezičnih/nacionalnih zajednica. Takva struktura naručitelja, s uspostavljenim složenim isprepletenim mrežama, ostvarila je uvjete za intenzivnu migraciju umjetničkih djela te mobilnost i prekogranično/regionalno djelovanja umjetnika koja će rezultirati snažnim povezivanjem srednjoeuropskog prostora. Mreže umjetničkih odnosa istraživat će se na makro-razini kao i na mirko-razini. Istraživanjem, sistematizacijom podataka i rezultata, omogućit će se i ubrzavanje procesa obnove ove baštine, stradale u potresu.]]></summary_hr><summary_en><![CDATA[The period of the 17th and the long 18th century was marked by a significant increase in artistic activity in Zagreb and its surroundings, as well as in other regions of Central Europe (Baroque bauboom). It is the result of an intensive process of concentration of commissioners and a wide range of their commissions in the city which became an artistic and cultural centre, strongly connected with the neighbouring regions, densely networked into culturally and artistically pluralistic continuum.Using a new approach to art patronage, the project aims to explore the wide-ranging different forms of commissioning practice in the social and cultural context of its origin. We see art commissioning as a complex interconnected system of activities, which is based on a network of relationships between artists and their commissioners, one of the key components in shaping the identifying framework and a visible means of (self)confirmation. The research corpus comprises works of art connected with Zagreb by their place of creation, commission, and origin of the artist or the commissioner. In a city that became the centre of high-social-class gatherings and cultural consumption, the project will research the heterogeneous structure of artists and commissioners, with an emphasis on individuals from the ranks of social elites (nobility, church and military dignitaries), as well as the role of groups (church orders) and different linguistic/national communities. Patronage was also an important factor in the process of cultural exchange, the established complex networks facilitated an intensive exchange of artworks and cross-border/regional mobility of artists. The intertwined art network will be studied at both and micro levels. This project will also contribute to the restoration of this corpus after damages in the earthquakes of 2020. Systematic research, systematization of collected data and results will create conditions for accelerating the restoration process.]]></summary_en></project><project>
<id>15487</id><title_hr><![CDATA[Integrirani komunikacijski i senzorski sustavi usmjereni na ljudsko tijelo]]></title_hr><title_en><![CDATA[Integrated Body-Centric Communication and Sensor Systems]]></title_en><user_id>6686</user_id><user_firstLast_name>Zvonimir Šipuš</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-3029</code><acronim><![CDATA[BODYSEN]]></acronim><duration>31.12.2023 - 30.12.2027</duration><status>U tijeku</status><financ_value>195.374,61 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, Računarstvo, Tekstilna tehnologija, </scie_field_hr><scie_field_en>Electrical engineering, Computer sciences, Textile technology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>6555, 6893, 866392, 26560, 865118, 864956, 869950, 873101, </team_members_id><team_members_names><![CDATA[Davor Bonefačić, Marko Bosiljevac, Nikša Burum, Sonja Grgić, Dubravko Tomić, Ivana Žeger, Karla Sever, Marko Smolić, ]]></team_members_names><keywords_hr><![CDATA[senzorski sustavi, nosive antene, tekstilne antene, implantabilne antene, implantabilni senzori, pametna koža, metapovršine, daljinska detekcija]]></keywords_hr><keywords_en><![CDATA[sensor systems, wearable antennas, textile antennas, implantable antennas, implantable sensors, smart skin, metasurfaces, remote sensing]]></keywords_en><summary_hr><![CDATA[Jedan od glavnih izazova u razvoju komponenti za sustave usmjerene na ljudsko tijelo je dizajn uređaja koji može u isto vrijeme zadovoljiti tehničke uvjete i ispuniti netehničke zahtjeve. Na primjer, uređaji na ljudskom tijelu trebali bi biti estetski prihvatljivi i prikladni za nosive aplikacije, dok bi uređaji za implantaciju trebali biti volumno maleni i izrađeni od biološki prihvatljivih materijala. Različite primjene dovele su do mnogih otkrića u sustavima usmjerenim na tijelo u područjima zdravstvene skrbi, sporta, državne službe i zabave. Stoga je cilj projekta individualno razviti i naknadno integrirati različite uređaje za sustave usmjerene na tijelo i proširiti njihove komunikacijske i senzorske mogućnost primjenom novih tehnologija. Razmatrat će se svi elementi senzora i komunikacijskog sustava: u tijelu (kapsula senzora za implantaciju), na tijelu (nosivi pametni prsluk i pametna koža) i izvan tijela (antenski sustav temeljen na anteni s više glavnih latica za praćenje i komunikaciju u zatvorenom prostoru). Pri tome ćemo koristiti nove koncepte u dizajnu koji su nedavno predstavljeni, kao što su metapovršine, periodične strukture s višim simetrijama, tekstilne valovodne antene, implantabilne antene konstruirane prateći temeljna ograničenja te skeniranje optimizirano metodom strojnog učenja. Proces dizajna započet će analitičkim modeliranjem kanonskih slučajeva, realizacijom prototipova za dokaz koncepta i konačno razvojem komponenti prikladnih za integraciju u sustav usmjeren na ljudsko tijelo. To će omogućiti razvoj jedinstvenog sustava koji će imati potencijal pružanja opsežnih senzorskih informacija u stvarnom vremenu za više osoba ili objekata u različitim okruženjima. Dostizanjem konačnog cilja i demonstriranjem funkcionalnog višenamjenskog prototipa senzorskog i komunikacijskog sustava usmjerenog na ljudsko tijelo, imat ćemo platformu koja će imati potencijal biti okosnica u različitim biomedicinskim primjenama kao i u drugim industrijskim granama.]]></summary_hr><summary_en><![CDATA[One of the major challenges in the development of components for body-centric systems is to design a device that can at the same time satisfy technical requirements and fulfil non-technical requests. For example, on-body devices should be aesthetically acceptable and suitable for wearable applications, while implantable devices should be small and made of biologically acceptable materials. Various applications has led to many breakthroughs in body-centric systems focused on healthcare, fitness, civil services and entertainment. Therefore, the goal of the project is to individually develop and subsequently integrate different devices for body-centric systems and to extend their communication and sensing possibilities using new technologies. All elements of the sensor and communication system will be considered: in-body (implantable sensor capsule), on-body (wearable smart-vest and smart-skin) and off-body (multibeam antenna system for tracking and communication in indoor environment). In these developments we will use novel concepts which were recently introduced, such as metasurfaces, periodic structures with higher symmetry, textile waveguide antennas, implantable antennas designed by following fundamental limits on radiated power, and machine learning optimized scanning. The design process will start with analytic modelling of canonical cases, realization of proof-of-concept prototypes, and finally development of components suitable for integration into a body-centric system. This will allow development of a unified system which will have the potential to provide extensive real-time sensing information for multiple persons or objects in various environments. By reaching the final objective and demonstrating a functional multipurpose body-centric sensing and communication system prototype we will have a platform which will have potential to serve as backbone in various biomedical application fields and also in other industrial fields inspired by new applications.]]></summary_en></project><project>
<id>15490</id><title_hr><![CDATA[Povezivanje ekološke uloge rastilišta i trofičkih obrazaca s dinamikom ribljih populacija i raznolikosti]]></title_hr><title_en><![CDATA[Linking nursery ecological role and trophic pathways with fish population dynamics and diversity]]></title_en><user_id>2707</user_id><user_firstLast_name>Sanja Matić-Skoko</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-7542</code><acronim><![CDATA[LinkFish]]></acronim><duration>29.12.2023 - 28.12.2027</duration><status>U tijeku</status><financ_value>173.600,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, Interdisciplinarne prirodne znanosti, </scie_field_hr><scie_field_en>Biology, Interdisciplinary natural sciences, </scie_field_en><institution_hr><![CDATA[Institut za oceanografiju i ribarstvo]]></institution_hr><institution_en><![CDATA[Institute of Oceanography and Fisheries]]></institution_en><team_members_id>1215, 4583, 4946, 3958, 3959, 19894, 27428, 20129, 866380, 866379, 866417, 869685, 872875, 870110, </team_members_id><team_members_names><![CDATA[Jakov Dulčić, Pero Tutman, Branko Dragičević, Dubravka Bojanić Varezić, Nika Stagličić, Dario Vrdoljak, Mišo Pavičić, Marcelo Kovačić, Peter Groenkjaer, Brian Kennedy, Fabio Pranovi, Lea Madunić, Tonći Milardović, Nika Ugrin, ]]></team_members_names><keywords_hr><![CDATA[otolit, geokemija, stabilni izotopi, ekološka uloga, trofički odnosi, antropogeni pritisak, zajednica nedoraslih riba]]></keywords_hr><keywords_en><![CDATA[otolith, geochemistry, stable isotope, ecological role, trophic relationships, anthropogenic pressure, juvenile fish community]]></keywords_en><summary_hr><![CDATA[Određivanje vrijednosti obalnih rastilišta za obilje populacije i rast ekonomski važnih ili iskorištavanih vrsta je složen, ali kritično potreban zadatak. Kondicija nedorasle jedinke je odraz rasta i rezultat je stresa u okolišu, ekoloških interakcija (ishrana i predacija) i aktivnosti. Međutim, staništa koja podržavaju dobro kondicionirane nedorasle jedinke mogu nesrazmjerno doprinositi obilju odraslih jedinki te je neophodna pouzdana kvantifikacija specifičnih demografskih stopa za rastilišta koja određuju povezanost između geografski odvojenih nedoraslih i odraslih jedinki. Nažalost, morski ekosustavi su degradirani do te mjere da neka kritična obalna staništa više nisu dostupna ili prikladna za pružanje funkcija rastilišta, ishrane ili reprodukcije, što je rezultiralo negativnim posljedicama na stanje i obnavljanje populacija. Pretpostavljamo da se nedorasle ribe ponašaju u skladu s adaptivnim donošenjem odluka kako bi izbjegle loše hidrografske uvjete, izgladnjivanje i predaciju. Radi testiranja, moramo identificirati mogućnosti preživljavanja nedoraslih riba i različite uvjete za rast u različitim staništima te utvrditi uspješnost identificiranih rastilišta u ispunjavanju funkcionalnih uloga. Predloženo istraživanje olakšat će razvoj novih analiza biološkog funkcioniranja  na razini ekosustava i antropogenog utjecaja u morskim i prijelaznim okolišima. Primjenjivat će se najnovije tehnike uzorkovanja te pažljive pripreme i obrade uzoraka. Za geokemijske analize otolita i analize stabilnih izotopa koristit će se sofisticirani alati i najnovija tehnologija. Analiza podataka će uključivati programiranje u R-u, ekološko modeliranje i korištenje suvremene višeparametarske analize. Opći cilj ovog projektnog prijedloga je pružiti osnovne informacije potrebne za definiranje nepoznanica koje su potrebne za kvantificiranje vrijednosti rastilišta za gospodarski iskorištavane vrste u obalnim zajednicama i ponuditi pomoć u definiranju ključnih staništa za zaštitu i obnovu.]]></summary_hr><summary_en><![CDATA[Determination of coastal nurseries value for population abundance and growth of economically important or exploited species, is a complex but critically needed task. Juvenile fish condition as reflection of growth is result of environmental stress, ecological interactions (e.g., diet and predation), and fish activity. However, habitats that support well-conditioned juveniles may disproportionately contribute to the adult stock and reliable quantification of nursery habitat speci?c demographic rates determining connectivity among geographically segregated juveniles and adults is necessary. Unfortunately, marine ecosystems have been degraded to the extent that some critical coastal habitats are no longer available or suitable to provide nursery, feeding or reproductive functions, resulting in negative consequences on production and renewal of populations. We hypothesise that fish behave in a manner consistent with adaptive decision-making to avoid poor hydrographic conditions, starvation and predation. In order to test this, we have to identify juveniles’ chance of survival and different conditions for growth in different habitats, and determine the success of identified nurseries in fulfilling their functional roles. Proposed research will facilitate the development of novel, ecosystem-level analyses of biological functioning and anthropogenic forcing in marine and transitional environments. The latest techniques of sampling, careful sample preparation and processing will be applied. For otolith geochemistry and stable isotope analysis sophisticated tools and the latest technology will be used. Data analysis will include programming in R, ecological modelling and use of modern multiparameter analysis. The overall goal of the present project proposal is to provide baseline information needed to define knowledge gaps for quantifying the nursery value for exploited fish in coastal communities and offer aid in defining key habitats for protection and restoration.]]></summary_en></project><project>
<id>15494</id><title_hr><![CDATA[Osiguravanje dinamičke stabilnosti elektroenergetskih mreža temeljenih na izmjenjivačima]]></title_hr><title_en><![CDATA[Ensuring dynamic stability of future inverter-based AC power networks]]></title_en><user_id>6497</user_id><user_firstLast_name>Igor Kuzle</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-7347</code><acronim><![CDATA[DYNASTY]]></acronim><duration>31.12.2023 - 30.12.2027</duration><status>U tijeku</status><financ_value>197.756,98 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, Temeljne tehničke znanosti, </scie_field_hr><scie_field_en>Electrical engineering, Basic engineering sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>7194, 25599, 25604, 7186, 869558, </team_members_id><team_members_names><![CDATA[Matija Zidar, Matej Krpan, Tomislav Baškarad, Ninoslav Holjevac, Karlo Kobeščak, ]]></team_members_names><keywords_hr><![CDATA[dinamika, regulacija, stabilnost, elektroenergetske mreže temeljene na izmjenjivačima, interoperabilnost]]></keywords_hr><keywords_en><![CDATA[dynamics, control, stability, inverter-based power systems, interoperability]]></keywords_en><summary_hr><![CDATA[Postoji jasan trend masovnog prodora uređaja temeljenih na elektroničkim energetskim pretvaračima u elektroenergetske sustave, prvenstveno zbog potrebe za sinkronizacijom različitih izvora temeljenih na izmjeničnoj i istosmjernoj struji s konvencionalnim elektroenergetskim sustavom. Ovaj prodor značajno mijenja karakteristike konvencionalnih velikih elektroenergetskih sustava. Nove karakteristike uključuju bržu dinamiku, kraća vremenska kašnjenja, oslabljenu sposobnost prigušenja poremećaja i smanjenje konstante tromosti sustava. Nadalje, distribucijske mreže postaju aktivne i cijela mreža se pomiče prema decentraliziranoj strukturi u kojoj se mogu pojaviti autonomne mikromreže ili otočni sustavi u potpunosti sačinjeni od izmjenjivača. Dok pretvarači nude fleksibilnost, visoku učinkovitost i omogućuju integraciju različitih proizvođača i potrošača u moderni elektroenergetski sustav, postoje i određeni problemi povezani s njihovom primjenom koji motiviraju kontinuirana istraživanja. Postoji mnoštvo metoda kojima se pretvarači mogu dizajnirati i upravljati. Brzina upravljačkih krugova, načini modulacije, vrsta pasivnih filtara i tehnike sinkronizacije s mrežom mogu općenito biti potpuno različite za pretvarače različitih proizvođača, instaliranih u međusobnoj blizini. To može dovesti do neželjenih interakcija, uzrokovati probleme sa stabilnošću i utjecati na rad sustava. Nedavni primjeri iz prakse pokazali su da se neželjeno dinamičko vladanje može pojaviti u sustavima s visokim udjelom pretvarača. Cilj ovog projekta je sustavno istražiti interakcije između različitih konfiguracija pretvarača, kao i između pretvarača i drugih elemenata velikog elektroenergetskog sustava. To će doprinijeti razvoju novih metodologija dizajna i upravljanja pretvaračima kako bi se osigurala interoperabilnost i robusnost, kao i pružio uvid u dinamička svojstva i stabilnost elektroenergetskih sustava kojima dominiraju energetska elektronika.]]></summary_hr><summary_en><![CDATA[There is a clear trend of a massive penetration of power electronics based devices in electric power systems due to the need for synchronization of various AC and DC sources to the AC power grid. This penetration significantly changes the characteristics of conventional bulk power systems. New characteristics include faster dynamics, shorter time delays, weakened damping ability and reduction of synchronous inertia. Moreover, distribution grids become active and the whole grid is shifting towards a more decentralized structure where 100% inverter-based islands or autonomous microgrids may occur. While power electronic converters do offer flexibility, high efficiency and enable the integration of various new grid elements into a modern power system, there are also certain issues associated with their deployment that drive ongoing research efforts. There is a plethora of design methodologies and control algorithms that are already available for grid-forming or grid-following converters. Control bandwidths, modulation methods, type of passive filters and frequency synchronization techniques can be generally completely different for power electronics converters from different vendors, installed in proximity of each other. This can lead to interactions, causing stability issues and impacting the operation of the system. Recent real-life events have proved that anomalous dynamics can arise in grids with high diffusion of converter-interfaced sources. In this project, the goal is to systematically explore the interactions between different configurations of power electronic converters as well as between power electronic converters and other elements of the bulk power grid. This will inform the development of new design and control methodologies of power electronic converters to ensure interoperability and robustness as well as bring insight into the dynamical properties and stability of power electronics dominated bulk power systems.]]></summary_en></project><project>
<id>15495</id><title_hr><![CDATA[Alternativni putevi rekombinacije i popravka DNA kod bakterija Escherichia coli i Deinococcus radiodurans]]></title_hr><title_en><![CDATA[Alternative pathways of DNA recombination and repair in Escherichia coli and Deinococcus radiodurans]]></title_en><user_id>5240</user_id><user_firstLast_name>Ksenija Zahradka</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-7476</code><acronim><![CDATA[AltRecPath]]></acronim><duration>28.12.2023 - 27.12.2027</duration><status>U tijeku</status><financ_value>138.622,36 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>5202, 5308, 5340, 869798, 869890, </team_members_id><team_members_names><![CDATA[Davor Zahradka, Damir Đermić, Jelena Repar, Filip Božić, Lucija Kumek, ]]></team_members_names><keywords_hr><![CDATA[Homologna rekombinacija, popravak DNA, Escherichia coli, RecBFI put, Deinococcus radiodurans, genomski rearanžmani, alternativno spajanje krajeva]]></keywords_hr><keywords_en><![CDATA[Homologous recombination, DNA repair, Escherichia coli, RecBFI pathway, Deinococcus radiodurans, genome rearrangements, alternative end-joining]]></keywords_en><summary_hr><![CDATA[Homologna rekombinacija (HR) je esencijalan biološki proces koji sudjeluje u popravku oštećenja molekule DNA i u očuvanju integriteta genoma. U bakteriji Escherichia coli, razlikuju se dva glavna puta homologne rekombinacije, RecBCD i RecFOR, koji koriste različite enzime za obradu krajeva DNA i vezanje rekombinaze RecA. U radiorezistentnoj bakteriji Deinococcus radiodurans, glavnina dvolančanih lomova DNA popravlja se pomoću dva HR procesa koja ovise o proteinu RecA – ESDSA i klasična homologna rekombinacija. Naša grupa je nedavno identificirala dva alternativna rekombinacijska puta: (i) RecBCD- RecFOR-neovisni (RecBFI) put rekombinacije koji djeluje u mutantima sbcB15 sbcCD bakterije E. coli, u kojem mutirani protein SbcB15 posreduje u sklapanju RecA filamenta i (ii) alternativno spajanje krajeva DNA (A-EJ), proces koji omogućava značajan, ali neprecizan RecA-neovisan popravak dvolančanih lomova DNA i koji rezultira velikim genomskim rearanžmanima kod bakterije D. radiodurans. U sklopu ovog projekta identificirat ćemo nove gene/proteine i uvjete koji potiču  RecBFI  rekombinaciju u bakteriji E. coli te A-EJ rekombinaciju (i posljedične genomske rearanžmane) u bakteriji D. radiodurans. U istraživanjima ćemo koristiti sekvenciranje nove generacije i napredne bioinformatičke alate (i) za identifikaciju supresorskih mutacija koje aktiviraju RecBFI rekombinaciju kod bakterije E. coli i (ii) za identifikaciju genomskih rearanžmana kod bakterije D. radiodurans. Kombiniranjem genetičkih, molekularno-bioloških i mikroskopskih metoda istražit ćemo učinak različitih mutacija od interesa na rast, vijabilnost i kapacitet bakterijskih stanica za popravak DNA te na morfologiju i segregaciju bakterijskih kromosoma. S obzirom da je homologna rekombinacija evolucijski vrlo sačuvan proces, rezultati naših istraživanja na bakterijama su relevantni za istraživanja karcinoma i drugih bolesti kod ljudi koje su povezane s defektima u rekombinaciji DNA i genomskim rearanžmanima. ]]></summary_hr><summary_en><![CDATA[Homologous recombination (HR) is an essential biological process that is involved in DNA repair and in the maintenance of genome integrity. In Escherichia coli, HR proceeds via two main pathways, RecBCD and RecFOR, that use different enzymes for DNA end resection and loading of RecA recombinase. In radioresistant bacterium Deinococcus radiodurans, the majority of double-strand DNA break (DSB) repair proceeds via two homology-driven processes, extended synthesis-dependent strand annealing and classical HR by crossovers, both of which require the RecA recombinase. We have recently identified two alternative recombination pathways: (i) the RecBCD- RecFOR-independent (RecBFI) recombination pathway that operates in sbcB15 sbcCD mutants of E. coli, in which the mutant SbcB15 protein act as a mediator of RecA filament assembly, and (ii) the alternative end-joing (A-EJ) that enables substantial but inaccurate RecA-independent DSB repair in D. radiodurans leading to gross genome rearrangements. In this project we aim to identify novel functions and conditions that facilitate RecBFI recombination pathway in E. coli and A-EJ pathway (and accompanying genome rearrangements) in D. radiodurans. The research will engage next-generation sequencing and advanced bioinformatic tools for (i) identification of suppressor mutations that facilitate RecBFI pathway in E. coli and (ii) identification of various types of genome rearrangements in D. radiodurans. In addition, genetic, molecular biology and cell biology (microscopy) approaches will be used to study the effect of different mutations of interest on bacterial growth, viability and DNA repair capacity as well as on chromosome morphology and segregation. Given that homologous recombination is a highly conserved process, our research on bacteria could be instructive for research on cancer and other human diseases associated with DNA recombination defects and genome rearrangements.]]></summary_en></project><project>
<id>15499</id><title_hr><![CDATA[Transformacija sekundarnog stanovanja u doba internetskog društvenog umrežavanja]]></title_hr><title_en><![CDATA[Transformation of Second Home Use in the Age of Online Social Networking]]></title_en><user_id>6867</user_id><user_firstLast_name>Geran-Marko Miletić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-8104</code><acronim><![CDATA[HomesNetting]]></acronim><duration>31.12.2023 - 30.12.2027</duration><status>U tijeku</status><financ_value>116.464,26 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Sociologija, </scie_field_hr><scie_field_en>Sociology, </scie_field_en><institution_hr><![CDATA[Institut društvenih znanosti Ivo Pilar]]></institution_hr><institution_en><![CDATA[Institute of Social Sciences Ivo Pilar in Zagreb]]></institution_en><team_members_id>2541, 6746, 866151, 6603, 3070, 856212, </team_members_id><team_members_names><![CDATA[Krešimir Peračković, Sara Ursic, Matea Milak, Marica Marinović Golubić, Mateo Žanić, Emma Kovačević, ]]></team_members_names><keywords_hr><![CDATA[sekundarno stanovanje, internetsko društveno umrežavanje, lokalni društveni odnosi, lokalni razvoj, Hrvatska]]></keywords_hr><keywords_en><![CDATA[second homes, online social networking, local social relations, local development, Croatia]]></keywords_en><summary_hr><![CDATA[Polazeći od pitanja potiču li tehnološki razvoj i šire društveno-gospodarske promjene u postmodernom/postindustrijskom svijetu nastavak procesa socijalne fragmentacije ili pak omogućuju razvijanje novih oblika društvenosti koji mogu pridonijeti snaženju otpornosti i održivosti lokalne zajednice, u središtu interesa ovoga projekta su promjene kroz koje prolazi sekundarno stanovanje, odnosno praksa povremenog korištenja drugoga stana za odmor i rekreaciju. Spomenute promjene povezane su s intenzivnijim korištenjem drugoga stana tijekom pandemije COVID-19 te nakon nedavnih potresa u Hrvatskoj. Promatrajući upravo količinu provedenog vremena ili pak realizaciju glavnih životnih interesa, u brojnim slučajevima teško je uočiti razliku između stalne i privremene rezidencije. Na taj način uspostavlja se novi model stanovanja koji ima obilježja rezidencijalne multilokalnosti. Pritom se ne radi samo o promjeni načina i dinamike korištenja drugoga stana već i o promjeni učinka njegovog korištenja na lokalnu zajednicu. U tom kontekstu sve važniju ulogu ima i širenje internetskog društvenog umrežavanja. Naime, dobar dio lokalne društvene interakcije preselio se u virtualnu dimenziju te društvene grupe susjedstva sve češće postaju katalizatori lokalnih društvenih odnosa. Imajući to na umu, cilj ovoga projekta je uz sagledavanje općih značajki procesa transformacije sekundarnog stanovanja u Hrvatskoj, istražiti i ulogu koju internetske društvene mreže imaju u oblikovanju te prakse, te posebno odnos koji se pritom uspostavlja među samim korisnicima stanova za odmor ali i između stalnih i povremenih stanovnika. Naznačene uvide planiramo ostvariti istraživanjem u kojemu ćemo kombinirati sekundarnu analizu popisnih rezultata s primarnim empirijskim istraživanjima koja uključuju anketna istraživanja na nacionalnom uzorku korisnika stanova za odmor te na uzorku stalnih i povremenih stanovnika dva naselja.]]></summary_hr><summary_en><![CDATA[The starting point of the project is the question whether technological development and socio-economic changes in the postmodern/post-industrial world encourage the process of further social fragmentation, or enable the development of new forms of sociability which can contribute to strengthening the resilience and sustainability of the local community. Hence, the focus of the project is on the changes which second home use is going through, i.e. the practice of occasionally using another property for rest and recreation. These changes are related to the more intensive use of second homes during the COVID-19 pandemic, and after recent earthquakes in Croatia. Observing the amount of stay in or the realisation of the main life interests, in numerous cases it becomes difficult to see the difference between permanent and temporary residence. Such establishment of a new dwelling model which has the characteristics of residential multi-locality does not imply only a change in the ways and dynamics of second home use, but also changes the effect of its use on the local community. In this context, the spread of online social networking plays an increasingly important role. A good part of local social interaction has moved into the virtual dimension, and neighbourhood social groups more and more become catalysts of local social relations. Knowing that, the aim of this project is to look at the general features of the transformation of second home use in Croatia, and to investigate the role which online social networks play in the shaping of this practice, and especially the relationship which is established between the users of second homes, but also between permanent and temporary residents. We plan to achieve the indicated insights through research combining a secondary analysis of census results with the primary empirical research, which includes a survey on a national sample of second home users and on a sample of permanent and temporary residents of two settlements.]]></summary_en></project><project>
<id>15501</id><title_hr><![CDATA[Integrirani mikrosustav za enzimatsku proizvodnju biovodika]]></title_hr><title_en><![CDATA[Integrated micro-system for enzymatic biohydrogen production]]></title_en><user_id>7049</user_id><user_firstLast_name>Bruno Zelić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-2175</code><acronim><![CDATA[MicroBioH2]]></acronim><duration>31.12.2023 - 30.12.2027</duration><status>U tijeku</status><financ_value>164.059,71 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Kemijsko inženjerstvo, Interdisciplinarne tehničke znanosti, </scie_field_hr><scie_field_en>Chemical engineering, Interdisciplinary technological sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet kemijskog inženjerstva i tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Chemical Engineering and Technology]]></institution_en><team_members_id>428, 6308, 6012, 869546, 872946, </team_members_id><team_members_names><![CDATA[Anita Šalić, Ana Jurinjak Tušek, Davor Valinger, Renata Vičević, Nera Bebek, ]]></team_members_names><keywords_hr><![CDATA[hidrogenaza tolerantna na kisik, eskpresija proteina, proizvodnja biovodika, mikroreaktor, integrirani sustav, optimizacija i modeliranje procesa]]></keywords_hr><keywords_en><![CDATA[oxygen tolerant hydrogenase, protein expression, biohydrogen production, microreactor, integrated system, process optimization and modeling]]></keywords_en><summary_hr><![CDATA[Minijaturizacija procesne opreme je jedan od pristupa koji se danas sve više koristi kako bi se intenzivirali procesi. Mali, kompaktni i prijenosni uređaji, koji se koriste na mjestu nastanka sirovine ili na mjestu primjene produkta, pronalaze brojne primjene u kemijskoj, farmaceutskoj i prehrambenoj industriji, proizvodnji biogoriva, medicini, senzorici, praćenju stanja okoliša i sl. Široka primjena mikrostruktiriranih uređaja u proizvodnji energije zavisi o mogućnosti izvedbe uređaja koji će biti održivi, trajni, ekonomski opravdani i prihvatljivi po okoliš. U današnje vrijeme su biogoriva (bioetanol, biodizel, bioplin i biovodik) ekonomski i po okoliš prihvatljiva alternativa fosilnim gorivima. U odnosu na druga biogoriva, vodik ima visok energetski potencijal, njegovim korištenjem ne nastaju emisije štetnih plinova, a specifična energija koju se dobiva iz vodika je 2,75 puta veća od energije koja nastaje iz goriva na bazi ugljikovodika.Vodik se proizvod različitim procesima, a u odnosu na kemijske procese, biološke procese proizvodnje vodika odlikuje manja specifična potrošnja energije, blagi reakcijski uvjeti, a kao supstrati se koriste prirodne komponente.U okviru projekta provest će proizvodnja biovodika u reakcijskom sustavu temeljenom na oksidaciji glukoze enzimom glukoza dehidrogenaza, koji za svoje djelovanje zahtjeva prisutnost koenzima NADP+. Regeneracijom koenzima enzimom, nastaju dva mola vodika po molu glukoze. U okviru razvoja potpuno integriranog proces proizvodnje biovodika u mikroreaktoru, proizvest će se enzim hidrogenaza iz Ralstonia eutropha H16 i genetski modificirane Escherichia coli. Proizvodnja biovodika provest će se u šaržnom i ponovljivom šaržnom reaktoru te u mikroreaktoru. Sastav medija i procesni uvjeti bit će optimirani, a uz vodene, kao reakcijski medij koristit će se i prirodna eutektička otapala s ciljem stabilizacije enzima i koenzima. Na kraju će se u svrhu optimizacije i uvećanja procesa razviti kinetički i matematički model.]]></summary_hr><summary_en><![CDATA[One of the approaches widely used today to intensify processes is miniaturization of process equipment. Small, compact and portable devices used at the source of the raw material or at the point of application of the product have numerous applications in the chemical, pharmaceutical and food industries, biofuel production, medicine, sensor technology, environmental monitoring, etc. The wide application of microstructured devices in power generation depends on the ability to produce devices that are sustainable, durable, economically justified, and environmentally sound. Nowadays, biofuels are economically and environmentally acceptable alternatives to fossil fuels. Hydrogen is the most promising alternative energy solution because it has a high energy potential, no harmful gasses are released during its use, and the specific energy obtained is 2.75 times greater than the energy obtained from hydrocarbon-based fuels.Compared to chemical processes of hydrogen production, biological processes are characterized by lower specific energy consumption, the process takes place under mild reaction conditions, and natural components are used as substrates.In the proposed research, the production of biohydrogen will be carried out in a reaction system based on the oxidation of glucose by the glucose dehydrogenase, which requires the presence of the coenzyme NADP+ for its catalytic action. Two moles of biohydrogen per mole of glucose are generated during coenzyme regeneration by hydrogenase. Hydrogenase will be produced using Ralstonia eutropha H16 and by expression of recombinant protein in E. coli. Biohydrogen production will be carried out in a batch and repetative batch reactor and in a microreactor. The medium composition and process conditions will be optimized, and natural deep eutectic solvents will be used in addition to aqueous media to stabilize enzymes and coenzymes. Finally, a kinetic and mathematical model will be developed to optimize and scale-up the process.]]></summary_en></project><project>
<id>15503</id><title_hr><![CDATA[Debljina i starost majki uzrokuju spolno ovisne negativne učinke na metabolizam lipida i upalu kod podmlatka]]></title_hr><title_en><![CDATA[Maternal Obesity and aging cause a sex specific adverse effects on lipid metabolism and inflammation in offspring]]></title_en><user_id>12663</user_id><user_firstLast_name>Kristina Starčević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-4578</code><acronim><![CDATA[ObeseMothers]]></acronim><duration>21.12.2023 - 20.12.2027</duration><status>U tijeku</status><financ_value>132.682,99 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Veterinarska medicina, Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Veterinary medicine, Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Veterinarski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Veterinary Medicine]]></institution_en><team_members_id>866375, 3611, 3601, 5392, 19715, 866403, 866409, 894, 866482, 221, 25364, </team_members_id><team_members_names><![CDATA[Sunčica Sertić, Mislav Đidara, Marcela Šperanda, Tomislav Mašek, Ivana Jarak, Ivana Mihoković Buhin, Ana-Marija Kovač, Marko Hohšteter, Marco Alves, Vedran Micek, Petra Roškarić, ]]></team_members_names><keywords_hr><![CDATA[debljina, starost, podmladak, dislipidemija, metabolički sindrom]]></keywords_hr><keywords_en><![CDATA[obesity, aging, offspring, dyslipidemia, metabolic syndrome]]></keywords_en><summary_hr><![CDATA[Metabolički profil majke tijekom trudnoće i kasnije utječe na metabolički profil njenog potomstva. Tijekom trudnoće, metabolizam lipida prolazi kroz složene promjene kako bi se prilagodio povećanim potrebama ploda. Patološke promjene u metabolizmu lipida predstavljaju ključno obilježje mnogih metaboličkih bolesti, stoga je razumijevanje metabolizma lipida tijekom trudnoće od iznimne važnosti za postavljanje temelja za zdraviju trudnoću i zdraviji postnatalni život.Kako bismo postigli ciljeve projekta, istražit ćemo nekoliko aspekata A) prijenos sklonosti razvitka metaboličkog sindroma i prekomjerne tjelesne mase s roditelja na potomstvo kao i utjecaj prehrane potomstva na težinu poremetnji B) Utjecaj dugoročnih učinaka visokokalorične/niskokalorične prehrane tijekom razvoja potomaka na metabolizam lipida i pojavu metaboličkih bolesti te specifične metaboličke odgovore povezane sa spolom koje bi mogle imati važne zdravstvene posljedice. C) Metabolički status majke može različito predisponirati ženske i muške potomke na metaboličke bolesti što rezultira spolno specifičnim odgovorima na pretilost. D) Utjecaj specifičnih promjena u metabolizmu lipida, upale i oksidativnog statusa koje se razvijaju kod starijih majki, samostalno ili u kombinaciji s pretilošću, a koje bi mogle uzrokovati promjene u metabolizmu F1 i F2 generacije.Konačno, podaci iz cjelokupnog projekta rezultirat će integracijom stečenog znanja iz svih eksperimenata i boljim razumijevanjem složenosti promjena metabolizma lipida u trudnoćama pretilih i starijih majki te odgovoriti mogu li ove promjene biti nasljedne kroz više generacija. Integrativni pristup omogućit će nam da predložimo nove pristupe prevenciji u svrhu  poboljšane ishoda trudnoće na koje je negativno utjecala pretilost i dob majki.]]></summary_hr><summary_en><![CDATA[Maternal metabolic profile during pregnancy and later affects the metabolic profile of their offspring. During the pregnancy, lipid metabolism undergoes complex changes to accommodate for the increased requirements. Pathological changes in the lipid metabolism represents the hallmark of many metabolic diseases, therefore, to understand the lipid metabolism during the pregnancy is of utmost importance to set the foundation for healthier pregnancies and healthier postnatal life. To achieve the project objectives we will investigate several hypothesis: A) Parental transmission of predisposition to obesity-related disorders to their offspring and which pathological changes in lipid metabolism could be translated to offspring and if these changes could be attenuated by dietary intervention with DHA, B) Influence of long-term effects of high-calorie/ low-calorie diet during rodent development on the lipid metabolism and onset of metabolic diseases in connection to specific sex related metabolic responses and differences that could have important health consequences. C) Maternal metabolic status can predispose differently female and male offspring to metabolic diseases resulting in sex specific responses to obesity. D)  The influence of specific changes in lipid metabolism, inflammation and oxidative status that develops in aging mothers, independently, or in the combination with obesity that could cause alterations in the metabolism of F1 and F2 generations.Finally, data from the whole project will result in the integration of gained knowledge from all experiments and in better understanding of complexity of changes of lipid metabolism in the pregnancies of obese and aged mothers and whether these maternal effects persist for several generations. Integrative approach will allow us to suggest new approaches for development and implementation of preventative measures to improve outcomes of the pregnancies affected by obesity and age.]]></summary_en></project><project>
<id>15504</id><title_hr><![CDATA[Semantičko-sintaktička klasifikacija glagola u hrvatskom jeziku ]]></title_hr><title_en><![CDATA[Semantic-Syntactic Classification of Croatian Verbs]]></title_en><user_id>2892</user_id><user_firstLast_name>Ivana Brač</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-8074</code><acronim><![CDATA[SEMTACTIC]]></acronim><duration>31.12.2023 - 30.12.2027</duration><status>U tijeku</status><financ_value>86.046,23 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filologija, </scie_field_hr><scie_field_en>Philology, </scie_field_en><institution_hr><![CDATA[Institut za hrvatski jezik]]></institution_hr><institution_en><![CDATA[Institute of Croatian Language]]></institution_en><team_members_id>19124, 23390, 3388, 2905, 26889, 25351, 2897, 23362, 19309, 872957, 1295, 865368, </team_members_id><team_members_names><![CDATA[Matea Andrea Birtić, Branimir Belaj, Kristina Štrkalj Despot, Siniša Runjaić, Maja Matijević, Daria Lazić, Ana Ostroški Anić, Mia Batinić Angster, Iva Nazalević Čučević, Ivona Gašparić, Ivana Filipović Petrović, Lidija Milković, ]]></team_members_names><keywords_hr><![CDATA[semantika, sintaksa, glagoli, valencijski obrasci, semantičke uloge]]></keywords_hr><keywords_en><![CDATA[semantics, syntax, verbs, valency patterns, semantic roles]]></keywords_en><summary_hr><![CDATA[Ciljevi su projekta odrediti semantičke skupine kojima pripada 500 najčešćih glagola u hrvatskom jeziku, njihove prototipne sintaktičke obrasce i semantičke uloge, teorijski istražiti odnos semantike i sintakse glagola unutar jedne semantičke skupine i među skupinama te izraditi bazu u kojoj će se na primjerima iz korpusa temeljito semantički i sintaktički obraditi glagoli.U okviru projekta istraživat će se semantička obilježja glagola i odnosi sinonimije, antonimije, troponimije i dr., zatim uloga glagola u kognitivnim mehanizmima metafore i metonimije te će se istraživati sintaktičke alternacije i druge gramatičke pojave. Praktični je rezultat projekta baza s 500 najčešćih glagola u hrvatskom kojima će na temelju primjera iz korpusa biti određeno značenje, pridružena semantička skupina, određene vrste dopuna i njihove semantičke uloge. Podjelom glagola u semantičke skupine i njihovim valencijskim opisom uočit će se sličnosti i razlike među glagolima jedne skupine te između različitih skupina, što će rezultirati boljim razumijevanjem odnosa sintakse i semantike. Pregledno prikazani rezultati u bazi i u radovima omogućit će bolje uključivanje hrvatskoga jezika u poredbena istraživanja te moguću razmjenu podataka s drugim bazama koje se temelje na istom ili sličnom načelu razdiobe. Projekt je važan za obradu prirodnoga jezika zbog pouzdanoga i temeljitoga opisa sintaktičkih obrazaca i semantičkih uloga te diferenciranih značenja, stoga će se rezultati moći koristiti za parsiranje, automatsko označivanje teksta, označivanje semantičkih uloga, unapređenje alata za strojno prevođenje, izradu materijala za učenje jezika i dr. Rezultati će koristiti profesorima hrvatskoga, studentima svih jezičnih smjerova, lingvistima te neizvornim govornicima. Ujedno će se ojačati istraživačke kompetencije mladih istraživača i doktoranda samostalnim znanstvenim istraživanjem, stručnim usavršavanjem te sudjelovanjem na konferencijama. Baza će se dopunjavati i nakon završetka projekta.]]></summary_hr><summary_en><![CDATA[The goals of the project are to classify the 500 most frequent verbs in Croatian into semantic classes, to determine verbs’ prototypical syntactic patterns and semantic roles, to investigate the relationship between the semantics and syntax of Croatian verbs within one semantic class and between classes, and to create a database in which verbs will be thoroughly semantically and syntactically analyzed based on examples from corpora. In this project, the semantic features of verbs will be researched, as well as the role of verbs in the cognitive mechanisms of metaphor and metonymy, syntactic alternations and other grammatical phenomena. The practical result of the project will be a database with the 500 most frequent verbs in Croatian, for which, based on examples from the corpora, meanings will be determined, a semantic class will be associated with each meaning, and syntactic patterns and semantic roles will be assigned. By dividing verbs into semantic classes and their valency description, similarities and differences between verbs will be observed, which will result in a better understanding of the syntax-semantics interface. Structured and clearly presented results in the database and in published papers will enable a better inclusion of Croatian in comparative research and a possible exchange of similar data with other databases that are based on the same or similar principles of distribution. The project is important for NLP due to the thorough description of syntactic patterns and semantic roles and differentiated meanings; therefore, it could be used for parsing, semantic role labeling, the improvement of machine translation tools, the creation of language learning materials, etc. The results will benefit teachers of Croatian, students, linguists, and non-native speakers. Furthermore, the research competencies of young researchers and a doctoral student will be strengthened through independent scientific research, workshops and conferences.]]></summary_en></project><project>
<id>15508</id><title_hr><![CDATA[LGBT+ inkluzivnost srednjih škola: stavovi, iskustva i potrebe različitih subjekata odgojno-obrazovnoga procesa]]></title_hr><title_en><![CDATA[LGBT+ inclusivity of secondary schools: attitudes, experiences and needs of different actors of the educational process]]></title_en><user_id>12926</user_id><user_firstLast_name>Marija Bartulović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-4713</code><acronim><![CDATA[LGBT-SIP]]></acronim><duration>21.12.2023 - 20.12.2027</duration><status>U tijeku</status><financ_value>59.856,32 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Pedagogija, Sociologija, </scie_field_hr><scie_field_en>Pedagogy, Sociology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>13252, 12864, 26567, 29582, 6366, </team_members_id><team_members_names><![CDATA[Barbara Kušević, Ana Širanović, Tanja Vučković Juroš, Zoran Horvat, Goran Livazović, ]]></team_members_names><keywords_hr><![CDATA[LGBT+ inkluzivnost, kritička pedagogija, učenici, nastavnici, roditelji, srednja škola]]></keywords_hr><keywords_en><![CDATA[LGBT+ inclusivity, critical pedagogy, students, teachers, parents, secondary school]]></keywords_en><summary_hr><![CDATA[Cilj je ovoga projekta istražiti stavove, iskustva i potrebe različitih subjekata odgojno-obrazovnoga procesa (nastavnika, članova stručnoga tima, ravnatelja, učenika i roditelja) u srednjim školama u domeni LGBT+ inkluzivnosti i primjenom metodologijskoga okvira akcijskoga istraživanja moderirati i opisati proces transformacije kulture škole u smjeru veće LGBT+ inkluzivnosti u jednoj odabranoj srednjoj školi. ]]></summary_hr><summary_en><![CDATA[The aim of this project is to explore attitudes, experiences and needs of various agents of the educational process (teachers, expert team members, school leaders, students and parents) in secondary schools in the domain of LGBT+ inclusivity and, by applying the methodological framework of action research, moderate and describe the process of transformation of school culture towards greater LGBT+ inclusivity in one selected secondary school.]]></summary_en></project><project>
<id>15510</id><title_hr><![CDATA[Unaprjeđenje ambalažnog proizvoda primjenom ekološki povoljnih materijala i inkluzivnog dizajna]]></title_hr><title_en><![CDATA[Improvement of packaging products by application of eco-friendly materials and inclusive design]]></title_en><user_id>19215</user_id><user_firstLast_name>Tomislav Cigula</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-3864</code><acronim><![CDATA[CirEiD]]></acronim><duration>19.12.2023 - 18.12.2027</duration><status>U tijeku</status><financ_value>144.941,88 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Grafička tehnologija, </scie_field_hr><scie_field_en>Graphics technology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Grafički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Graphic Arts]]></institution_en><team_members_id>866272, 866224, 23557, 866188, 865526, 866386, 869551, 26006, </team_members_id><team_members_names><![CDATA[Dorotea Kovačević, Rahela Kulčar, Katarina Itrić Ivanda, Daria Mustić, Marina Vukoje, Iva Šarčević, Teodora Lukavski, Josip Bota, ]]></team_members_names><keywords_hr><![CDATA[biokompozitni premazi, elektrovodljive boje, kromogene boje, interaktivna (pametna) ambalaža, inkluzivni dizajn, materijalno i organsko recikliranje]]></keywords_hr><keywords_en><![CDATA[biocomposite coatings, conductive inks, chromogenic inks, interactive (smart) packaging, inclusive design, materials and organic recycling]]></keywords_en><summary_hr><![CDATA[Grafička industrija će prema procjenama imati stabilan gospodarski rast u globalnim okvirima, najviše zahvaljujući porastu sektora ambalaže. Ambalaža uključuje razne materijale, no sve se više uključuju papirnati materijali koji imaju prihvatljiviji utjecaj na okoliš od primjerice polimernih materijala. Pored svijesti korisnika, ekološki aspekt plastike rezultirao je s EU direktivama o neprihvatljivosti korištenja plastike za jednokratnu upotrebu. Pored potrebe za povoljnijim ekološkim utjecajem prepoznaje se i potreba za prilagodbom sadržaja osobama s ograničenim senzornim sposobnostima. Naime, proizvodi i usluge se često ne prilagođavaju njima te takve osobe imaju smanjenu mogućnost sudjelovanja u aktivnostima i aspektima društva na jednak način. Uzevši u obzir oba izazova, cilj ovog projekta je unaprijediti ambalažne materijale kroz integraciju tri aspekta: razvoj materijala koji će biti povoljniji za okoliš, ispitati korisničko iskustvo i izraditi smjernice za poboljšani dizajn prilagođen osobama s ograničenim senzornim sposobnostima te poboljšati interaktivnost ambalaže te time poboljšati korisnički doživljaj. Za tu svrhu planira se razviti i optimizirati sastav premaza sa spojevima prirodnog podrijetla koji će zaštititi ambalažni materijal od propadanja, dodatno razvit će se ekološki povoljnije funkcionalne boje za omogućavanje interaktivnosti ambalaže s korisnikom. Konačno, temeljem ispitivanja korisničkog iskustva osoba sa specifičnim komunikacijskim potrebama stvorit će se smjernice za dizajn proizvoda kojim će se postići veća uključenost tih skupina u društvene aktivnosti. Očekuje se da će navedeno istraživanje unaprijediti postojeće ambalažne materijale pružajući veću izdržljivost, omogućiti interaktivnost s korisnicima te poboljšati korisničko iskustvo osoba sa specifičnim komunikacijskim potrebama, a korištenjem ekološki povoljnijih materijala pozitivno će se utjecati na materijalno i organsko recikliranje iskorištenog ambalažnog proizvoda.]]></summary_hr><summary_en><![CDATA[Graphic arts industry is predicted to have stable economic growth, mainly due to the increase of the packaging industry. Packaging includes vast variety of materials, but paper and paper type materials (PTM) are more and more included. The inclusion of the PTM is due to their influence on environment compared to plastics. Bad environmental effect resulted with EU directives which banned single use plastics. Beside necessity of environmental aspects, there is also need for adjustment of content to the people with visual sensory loss (PVSL). Majority of products and services are not adjusted to them, which lowers their participation in various social aspects equally as others. Therefore, this project proposal aims to improve packaging materials by improving their three aspects: development of the materials which will be environmentally friendlier, to examine user experience and determine guidelines for improvement of packaging product’s design, adjusted to the PVSL, and improve interactivity of the packaging to improve its user experience. To achieve those goals, researchers will develop and optimize composure of coatings with addition of compounds of natural origin, which will protect packaging material from deterioration. Second, development and optimization of functional printing inks with lowed environmental impact will be performed. These inks will enable adding interactivity of packaging with its. Finally, based on the user experience research of the users with specific communication needs, guidelines for packaging product design will be made to enhance inclusion of those user into the social activities. It is expected that this research will improve packaging materials by giving them higher durability, enabling them interactivity with the users and increasing user experience of people with special communication needs, while, simultaneously, using environmentally friendlier material will improve material and organic recycling of used packaging materials.]]></summary_en></project><project>
<id>15521</id><title_hr><![CDATA[Premošćivanje disciplinarnog jaza: integracija animalne genetike i arheologije u Hrvatskoj]]></title_hr><title_en><![CDATA[Bridging the Disciplinary Gap: Integrating Animal Genetics and Archaeology in Croatia]]></title_en><user_id>7343</user_id><user_firstLast_name>Vlatka Čubrić Čurik</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-8926</code><acronim><![CDATA[GAbridge]]></acronim><duration>20.12.2023 - 19.12.2027</duration><status>U tijeku</status><financ_value>198.888,39 eur</financ_value><scie_area_hr>Interdiciplinarne znanosti, Biotehničke znanosti, Humanističke znanosti, Prirodne znanosti, Društvene znanosti, </scie_area_hr><scie_area_en>Interdisciplinary scientific area, Biotechnical sciences, Humanities, Natural sciences, Social sciences, </scie_area_en><scie_field_hr>Interdisciplinarne biotehničke znanosti, Poljoprivreda, Arheologija, Interdisciplinarne prirodne znanosti, </scie_field_hr><scie_field_en>Interdisciplinary biotechnical sciences, Agriculture, Archeology, Interdisciplinary natural sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Agronomski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Agriculture]]></institution_en><team_members_id>6650, 7067, 6279, 1339, 4140, 25165, 26023, 13425, 856141, 24490, 19007, 869691, </team_members_id><team_members_names><![CDATA[Ino Čurik, Ivana Držaić, Maja Ferenčaković, Dinko Novosel, Strahil Ristov, Rajna Šošić Klindžić, Maja Grgurić Srzentić, Maja Krznarić Škrivanko, Goran Tomac, Neven Antunac, Vladimir Brajković, Ivana Keršić, ]]></team_members_names><keywords_hr><![CDATA[arheogenetika, genomika, arheologija, goveda, domestikacija]]></keywords_hr><keywords_en><![CDATA[archaeogenetic, genomic, archaeology, cattle, domestication]]></keywords_en><summary_hr><![CDATA[Projekt Mendthegap je bila inovativna prilika da se poprave nedostaci u istraživačkom kapacitetu o prošlosti u Hrvatskoj u arheologiji i genetici te da se te dvije discipline približe. Održivost projekta Mendthegap je započela izgradnjom istraživačkih kapaciteta, odnosno osnivanjem Laboratorija za arheogenetiku Agronomskog fakulteta gdje je moguće raditi arheogenetičke analize. Budući je otključan latentan znanstveni potencijal u RH, projekt GAbridge bi donio direktne znanstvene rezultate o podrijetlu i prošlosti goveda u RH. Metode slijedeće-generacije sekvenciranja (NGS) i računalnih kapaciteta otvorili su veliki broj novih mogućnosti u različitim znanstvenim područjima (humanoj i veterinarskoj medicini, poljoprivredi, šumarstvu, ekologiji, računalnoj znanosti, pa čak i arheologiji. Ovdje smo okupili stručnjake iz molekularne genetike, populacijske genomike, uzgoja životinja, računalnih znanosti i arheologije kako bismo odgovorili na nekoliko tema vezanih uz populacijsku genomiku i  biološku raznolikost (izmiješanost i populacijska struktura) te širenja goveda na našim prostorima kao najvažnije domaće životinje za razvoj čovječanstva. Analizom drevnih kostiju goveda (>12.000) godina poboljšali bismo naše razumijevanje o genomskim promjena u postupku domestikacije. Naš projektni prijedlog ima snažnu komponentu teorijskih dostignuća za procjenu genetske introgresije, efektivne veličine populacije i pojedinačnog umješavanja. Osim toga, NGS izvodit će se na drevnim govedima sa slijedećim ciljevima; (i) utvrditi genetsku raznolikost preživača u paleolitiku: razumijevanje genetike predomestikacije, (ii) doprinjeti razumijevanju procesa pripitomljavanja tijekom neolitizacije u Hrvatskoj; (iii)razrješiti kronologiju širenja goveda: grafovima rekombinacije predaka (iv) istražiti genetsko podrijetlo hrvatskih pasmina goveda te (v) premostiti disciplinarni jaz i uspostaviti dugoročnu suradnju arheologa i genetičara u cilju otključavanja prošlosti.]]></summary_hr><summary_en><![CDATA[The Mendthegap project was an innovative way to fill the gaps in the research capacity on the past in Croatia in the fields of archeology and genetics and to bring these two disciplines closer together. The sustainability of the Mendthegap project began with research capacity building, i.e. with the establishment of the Laboratory of Archaeogenetics at the Faculty of Agriculture, where archaeogenetic analyzes can be carried out. As the latent scientific potential has been tapped in the Republic of Croatia, the GAbridge project would provide direct scientific results on the origin and past of cattle in the Republic of Croatia. Next generation sequencing (NGS) methods and data processing capabilities have opened a wide range of new opportunities in various scientific fields. Here we have gathered experts in molecular genetics, population genomics, animal breeding, informatics, and archeology to answer various questions related to population genomics and biodiversity (mixing and population structure) and the distribution of cattle in our region as the most important domestic animal for the development of mankind. By analyzing ancient cattle bones (> 12,000) years, we would improve our understanding of genomic changes in the process of domestication. Our project proposal includes a strong component of theoretical power to estimate genetic introgression, effective population size, and individual admixture. In addition, NGS will be performed on old cattle with the following objectives: (i) determine the genetic diversity of ruminants in the Paleolithic: understand the genetics of predomestication, (ii) contribute to the understanding of the domestication process during the Neolithic in Croatia, (iii) clarify the chronology of cattle distribution: (iv) investigate the genetic origin of Croatian cattle breeds, and (v) bridge the disciplinary gap and establish a long-term collaboration between archeologists and geneticists to decipher the past.]]></summary_en></project><project>
<id>15523</id><title_hr><![CDATA[Analiza interakcija organofosfornih spojeva s esterazama i mogućim metama terapije kod otrovanja]]></title_hr><title_en><![CDATA[Analyses of interactions between organophosphorus compounds and esterases and other targets for therapy in poisoning]]></title_en><user_id>411</user_id><user_firstLast_name>Nikolina Maček Hrvat</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-6685</code><acronim><![CDATA[OPEsterOX]]></acronim><duration>16.12.2023 - 15.12.2027</duration><status>U tijeku</status><financ_value>198.818,76 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, Biologija, </scie_field_hr><scie_field_en>Chemistry, Biology, </scie_field_en><institution_hr><![CDATA[Institut za medicinska istraživanja i medicinu rada]]></institution_hr><institution_en><![CDATA[Institute for Medical Research and Occupational Health]]></institution_en><team_members_id>24011, 2835, 489, 28637, 861724, 5926, 872944, 871143, </team_members_id><team_members_names><![CDATA[Vesna Gabelica Marković, Višnja Stepanić, Goran Šinko, Tena Cadez, Dora Kolić, Zoran Radić, Petar Nakić, Petra Tuksar, ]]></team_members_names><keywords_hr><![CDATA[acetilkolinesteraza, antidoti, butirillkolinesteraza, OPNA, reaktivacija, oksimi, organofosfati, toksičnost]]></keywords_hr><keywords_en><![CDATA[acetylcholinesterase, antidotes, butyrylcholinesterase, OPNA, reactivation, oximes, organophosphate, toxicity]]></keywords_en><summary_hr><![CDATA[Izloženost organofosfatima (OP) od kojih su neki pesticidi ili živčani bojni otrovi (ŽBO) dovodi do inhibicije enzima acetilkolinesteraze (AChE) ključnog za funkcioniranje živčanog sustava. Blokiranje aktivnosti izaziva kolinergičku krizu, odnosno pretjeranu stimulaciju muskarinskih i nikotinskih membranskih receptora u središnjem i perifernom živčanom sustav, što može dovesti do dugotrajnih posljedica trovanja pa i do smrti. Standardna terapija trovanja OP koja uključuje primjenu antimuskarinika, atropina i oksimskog reaktivatora AChE, nije učinkovita za različite OP, posebice nije za fosforoamidate radi strogo-strukturalno ovisnog mehanizma reaktivacije enzima. Alternativna terapija odnosi se na srodni enzim butirilkolinesterazu (BChE) koji veže OP spojeve u cirkulaciji i kao takav djeluje kao stehiometrijsko biočistilo OP. Stoga ovaj projekt koristi poznate (npr. tabun, metamidofos i fenamifos) i neistražene spojeve (A-seriju organofosfata) za bolje razumijevanje mehanizama interakcija kolinesteraza s fosforoamidatima s ciljem pronalaska učinkovitih načina terapije. Biokemijski mehanizam interakcija enzima sveobuhvatno će se proučavati na molekulskoj razini metodama in silico, in vitro i ex vivo kako bi se odredili afiniteti vezanja, brzine inhibicije i učinkovitost reaktivacije enzima. Mehanizmi toksičnosti odabranih OP studirat će se na staničnom nivou. Najučinkovitiji reaktivatori testirat će se kao antidoti na miševima izloženim OP. Također, na mišjem mozgu ispitat će se neuroinflamatorni učinak OP kao i neuroprotektivna djelotvornost oksimske terapije praćenjem specifičnih markera astroglioze, mikroglioze i vijabilnosti neurona. Ove sveobuhvatne analize doprinijet će neupitno poznavanju interakcija fosforoamidata i učinkovitije terapije u otrovanju s njima i sličnim OP.]]></summary_hr><summary_en><![CDATA[Exposure to organophosphates (OP) from both pesticides and nerve agents leads to the covalent inhibition of the pivotal enzyme acetylcholinesterase (AChE) that leads to accumulation of neurotransmitter acetylcholine, which induces cholinergic crisis, that is, overstimulation of muscarinic and nicotinic membrane receptors in the central and peripheral nervous system. In severe cases, subsequent desensitisation of the receptors results in hypoxia, vasodepression, and respiratory arrest, followed by death. Standard therapy of OP poisoning that generally involves administration of anticholinergic atropine and an oxime reactivator of phosphylated AChE has limitations especially in the case of phosphoroamidates due to the structural-related mechanism of reactivation. An alternative therapy is the related enzyme butyrylcholinesterase (BChE) which binds OP compounds and as such acts as stoichiometric bioscavenger of OP. Therefore, this project utilizes known (e.g. tabun, methamidophos and fenamiphos), and new compounds (A-agents) to gain a better understanding of the mechanistic basis of cholinesterase family interactions and their limitations to find new effective leads for treatment. The biochemical mechanism of enzyme interactions will be comprehensively studied on a molecular level with in silico, in vitro, and ex vivo methods to define binding affinities, kinetic constants of inhibition and efficiency of reactivation of both enzymes. The possible mechanisms of toxicity of selected OPs will be studied at cell-culture level, and on mice exposed to OP. The neuroinflammatory effect of OP as well as the neuroprotective effectiveness of oxime therapy will be examined on the mouse brain by monitoring specific markers of astrogliosis, microgliosis and neuron viability. These comprehensive analyses will undoubtedly contribute to the knowledge of phosphoroamidate interactions and improved therapeutics in OP poisoning.]]></summary_en></project><project>
<id>15524</id><title_hr><![CDATA[Odgovor na inovacije u fenomici I genomici u oplemenjivanju mliječnih goveda]]></title_hr><title_en><![CDATA[Responding to innovations in phenomics and genomics in dairy cattle breeding]]></title_en><user_id>6650</user_id><user_firstLast_name>Ino Čurik</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-6914</code><acronim><![CDATA[PhenoGeno]]></acronim><duration>29.12.2023 - 28.12.2027</duration><status>U tijeku</status><financ_value>197.989,25 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, Biotehnologija, </scie_field_hr><scie_field_en>Agriculture, Biotechnology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Agronomski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Agriculture]]></institution_en><team_members_id>6279, 1339, 7343, 4140, 24490, 23378, 2738, 539, 869704, 865128, 6771, 872952, </team_members_id><team_members_names><![CDATA[Maja Ferenčaković, Dinko Novosel, Vlatka Čubrić Čurik, Strahil Ristov, Neven Antunac, Nataša Mikulec, Boris Lukić, Nikola Raguž, Zvonimir Mijadžiković, Mario Shihabi, Marija Spehar, Dario Domović, ]]></team_members_names><keywords_hr><![CDATA[Govedarstvo, proizvodnja mlijeka, genomika, fenomika, kvantitativna genetika]]></keywords_hr><keywords_en><![CDATA[Cattle breeding, Dairy production, Genomics, Phenomics, Quantitative genetics]]></keywords_en><summary_hr><![CDATA[Primjena novih pristupa fenotipizaciji, napredna genotipizacija (genotipizacija visoke propusnosti na razini cijelog genoma, SNP nizovi) te genomski i statistički razvoj (genomska selekcija i one-step GBLUP) doveli su do ubrzanog genetičkog napretka u svim zemljama u razvoju mljekarstva. To vrijedi i za druga područja uzgoja životinja. Nažalost, Hrvatska je tek umjereno odgovorila na nova zbivanja, a naši uzgojni programi trenutačno uključuju samo relativno mali broj genotipiziranih krava i bikova na razini genoma. Istodobno, broj genotipiziranih životinja u razvijenim zemljama prelazi 100 000 životinja (> 300 000 goveda SNP-a u Austriji). Stoga smo odlučili predložiti moderan projekt u kojem ćemo razviti uzoran inovativni uzgojni program (s GWAS-om i procjenom genomskih parametara hrvatske holstein pasmine) koristeći najnovija tehnološka dostignuća u fenomici i genomici. U našem prijedlogu odlučili smo otići korak dalje od SNP nizova koji se danas rutinski koriste i temeljiti našu strategiju genotipizacije na najnovijoj mogućnosti (niskopropusno sekvenciranje cijelog genoma, lpWGS), jer bi to mogla biti najbolja strategija u našim relativno malim populacijama . Istodobno, naša napredna strategija fenotipizacije bila je usmjerena na uvođenje velikih mjerenja svojstava zgrušavanja mlijeka izvedenih iz FTIR spektra, budući da bi razvoj proizvodnje sira, kao u sjevernoj Italiji, mogao biti dobra strategija za hrvatski mljekarski sektor. Dok naš projekt ima vrlo snažnu primjenjivu komponentu, također smo ponudili niz analiza testirajući učinke zanemarenog nasljeđivanja, točnije učinke X-kromosoma i mito-nuklearnih interakcija na kvantitativne osobine (uključujući štetne aspekte), koje su prilično nove i revolucionarne hipoteze za uzgoj životinja, ali i za evolucijsku genetiku. Jedan mali aspekt projekta je &#39;&#39;igranje&#39;&#39; (eksperimentiranje) s detekcijom mikrobiote mlijeka iz lpWGS datoteka (FASTAq).]]></summary_hr><summary_en><![CDATA[The application of new phenotyping approaches, advanced genotyping (high-throughput genome-wide genotyping, SNP arrays), and genomic and statistical developments (genomic selection and one-step GBLUP estimation) have led to accelerated genetic progress in all dairy developing countries. This is also true for other areas of animal breeding. Unfortunately, Croatia has responded only moderately to the new developments, and our breeding programs currently include only a relatively small number of genome-wide genotyped cows and bulls. At the same time, the number of genotyped animals in developed countries exceeds 100,000 animals (> 300,000 SNP-arrayed cattle in Austria). Therefore, we decided to propose a modern project in which we will develop an exemplary innovative breeding program (with GWAS and estimation of genomic parameters in Croatian Holstein breed) using the latest technological advances in phenomics and genomics. In our proposal, we decided to go a step further than the SNP arrays routinely used today and base our genotyping strategy on the latest possibility (low-pass whole genome sequencing, lpWGS), as this might be the best strategy in our relatively small populations. At the same time, our advanced phenotyping strategy focused on introducing large-scale measurements of milk coagulation traits derived from FTIR spectra, as the development of cheese production, as in northern Italy, could be a good strategy for the Croatian dairy sector. While our project has a very strong applicable component, we have also offered a series of analyses testing the effects of neglected inheritance, more specifically the effects of X-chromosome and mito-nuclear interactions on quantitative traits (including deleterious aspects), which are quite new and ground-breaking hypotheses for animal breeding, but also for evolutionary genetics. One small aspect of the project is &#39;&#39;playing&#39;&#39; (experimenting) with detection of milk microbiota from lpWGS files (FASTQ).]]></summary_en></project><project>
<id>15542</id><title_hr><![CDATA[Biorafinerijski sustav za proizvodnju biogoriva i biokemikalija iz neprehrambenih lignoceluloznih sirovina]]></title_hr><title_en><![CDATA[Biorefinery system for biofuels and biochemicals production from non-food lignocelulosic raw materials]]></title_en><user_id>4332</user_id><user_firstLast_name>Božidar Šantek</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-3075</code><acronim><![CDATA[Biorefinery-NFLRM ]]></acronim><duration>29.12.2023 - 28.12.2027</duration><status>U tijeku</status><financ_value>199.076,56 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Biotehnologija, </scie_field_hr><scie_field_en>Biotechnology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Food Technology and Biotechnology]]></institution_en><team_members_id>4544, 6032, 450, 4912, 3709, 4098, 4100, 4102, 4438, 26476, 23620, 867750, </team_members_id><team_members_names><![CDATA[Draženka Komes, Mirela Ivančić Šantek, Tonči Rezić, Sunčica Beluhan, Vlatka Petravić Tominac, Antonija Trontel, Mario Novak, Mladen Pavlečić, Aleksandra  Vojvodić Cebin, Danijela Šeremet, Nenad Marđetko, Ana Dobrinčić, ]]></team_members_names><keywords_hr><![CDATA[neprehrambene lignocelulozne sirovine, biogoriva, biokemikalije, integrirani bioprocesni sustavi, biorafinerija III faze]]></keywords_hr><keywords_en><![CDATA[non-food lignocellulosic raw materials, biofuels, biochemicals, integrated bioprocess systems, III phase biorefinery ]]></keywords_en><summary_hr><![CDATA[Ovaj projekt se bavi razvojem biorafinerijskog sustava treće faze (eng. phase III biorefinery) za proizvodnju biogoriva (biodizela) i biokemikalija (polinezasićene masne kiselina, 2,3-butandiol, ksilitol, lignocelulitički enzimski koktel, polifenoli, pigmenti) iz neprehrambenih lignoceluloznih sirovina. Predobrade proučavanih sirovina provodit će se u visokotlačnom reaktoru uz primjenu razrijeđenih kiselina ili lužina. U drugom stupnju predobrade, čvrsti ostatak prvog stupnja hidrolize bit će podvrgnut enzimskoj hidrolizi pomoću komercijalnih enzimskih preparata ili mikroorganizama s relativno velikom lignocelulitičkom aktivnošću. U ovom istraživanju dobiveni hidrolizati neprehrambenih lignoceluloznih sirovina koristit će se pojediničano ili kao smjesa za proizvodnju biogoriva i biokemikalija kako bi se sastavila optimalna hranjiva podloga za njihovu proizvodnju. Za proizvodnju proučavanih biogoriva i biokemikalija odabrat će se najbolji radni mikroorganizam za pojedini biorafinerijski proizvod. Izdvajanje i pročišćavanje svakog pojedinog proizvoda biorafinerije bit će provedeno po inovativnom postupaku koji će biti integriran s procesom njegove proizvodnje kako bi se poboljšali ekološki i ekonomski aspekti održivosti svakog pojedinog bioprocesa. Održivost proizvodnje proučavanih proizvoda biorafinerije bit će procjenjena na osnovi LCA. Za održivu i učinkovitu konfiguraciju proučavanog bioprocesa razvit će se procedura za povećanje mjerila uz primjenu kriterija sličnosti. Formirani integrirani bioprocesni sustavi za proizvodnju biogoriva i biokemikalija iz neprehrambenih lignoceluloznih sirovina bit će sastavni dijelovi inovativnog biorafinerijskog sustava treće faze. ]]></summary_hr><summary_en><![CDATA[This project deals with the development of a phase III biorefinery system for the production of biofuels (biodiesel) and biochemicals (e.g. polyunsaturated fatty acids, 2,3-butanediol, xylitol, raw lignocellulitic enzyme cocktail, polyphenols, pigments) from non-food lignocellulosic raw materials. Pretreatment of the studied raw materials will be carried out in a high-pressure reactor using diluted acids or alkalis. In the second stage of pretreatment, the solid residue of the first stage of hydrolysis will be subjected to enzymatic hydrolysis using commercial enzyme coctails or microorganisms with relatively high lingocellulytic activity. In this research, the obtained hydrolysates of non-food lignocellulosic raw materials will be used individually or as a mixture for the production of biofuels and biochemicals in order to create an optimal nutrient medium for their production. For the production of studied biofuels and biochemicals, the most adequate working microorganism for each biorefinery product will be selected. The separation and purification of each individual product of the biorefinery will be carried out according to an innovative procedure that will be integrated with the process of its production in order to improve the ecologic and economic aspects of the sustainability of each individual bioprocess. The sustainability of the production of the studied products of the biorefinery will be assessed on the basis of LCA. For a sustainable and efficient configuration of the studied bioprocess, a scale-up procedure will be developed in order to increase the scale with the application of similarity criteria. The established integrated bioprocess systems for the production of biofuels and biochemicals from non-food lignocellulosic raw materials will be integral parts of the innovative III phase biorefinery system.]]></summary_en></project><project>
<id>15543</id><title_hr><![CDATA[Procjena dugotrajnog učinka klimatskih i antropogenih utjecaja na prostorno-vremensku dinamiku vegetacijskog pokrova u Hrvatskoj korištenjem satelitskih opažanja]]></title_hr><title_en><![CDATA[Assessment of the Long-term Climatic and Anthropogenic Effects on the Spatio-temporal Vegetated Land Surface Dynamics in Croatia using Earth Observation Data]]></title_en><user_id>20306</user_id><user_firstLast_name>Mateo Gašparović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-5711</code><acronim><![CDATA[ALCAR]]></acronim><duration>18.12.2023 - 17.12.2027</duration><status>U tijeku</status><financ_value>193.698,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Geodezija, </scie_field_hr><scie_field_en>Geodesy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Geodetski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Geodesy]]></institution_en><team_members_id>25342, 13129, 29484, 7009, 866492, 26381, 25970, 866277, 866288, 869745, 871154, 29753, 872766, 872778, 872863, 26373, 872905, </team_members_id><team_members_names><![CDATA[Mladen Zrinjski, Robert Župan, Dino Dobrinić, Ivan Pilaš, Damir Klobučar, Mladen Jurišić, Dorijan Radočaj, Geoffrey Henebry, Imelda Somodi, Filip Radić, Katarina Pavlek, Frane Gilić, Ronald Poeppl, Luka Antonić, Tomas Galia, Oleg Antonić, Ivana Jarak, ]]></team_members_names><keywords_hr><![CDATA[daljinska istraživanja, vegetacija, klimatske promjene, antropogeni učinci, pokrov i upotreba zemljišta]]></keywords_hr><keywords_en><![CDATA[remote sensing, vegetation, climate change, anthropogenic effects, land use land cover]]></keywords_en><summary_hr><![CDATA[Satelitska daljinska istraživanja predstavljaju neizbježan globalni izvor sinoptičkih podataka koji omogućuju retrospektivnu analizu dinamike kopnene površine pod vegetacijom te povezanih biogeofizičkih i biogeokemijskih procesa. Daljinska istraživanja omogućuju prikupljanje dugoročnih opažanja Zemlje, kao i informacije o unutarsezonskoj dinamici vegetacije ili &#39;&#39;fenologiji kopnene površine&#39;&#39;. Budući da trenutno ne postoje studije na nacionalnoj razini s vrlo visokom prostornom osjetljivošću na promjene zemljišnog pokrova kao posljedice povijesnih političkih i socioekonomskih trendova, ovim projektom upotrijebit će se najnovija dostignuća u suvremenom prediktivnom modeliranju i strojnom učenju. U tom smislu, glavni znanstveno-istraživački ciljevi projekta su:• Razviti tehnički okvir, temeljen na dugoročnom promatranju Zemlje i naprednoj obradi podataka, statističkim i algoritmima strojnog učenja, za procjenu prostorno-vremenske dinamike zemljišnog pokrova uslijed institucionalnih promjena i regionalnih utjecaja globalnih promjena okoliša.• Osigurati rezultate koji omogućuju preciznu procjenu utjecaja, ranjivosti i sposobnosti prilagodbe glavnih tipova vegetacije i klasa uporabe zemljišta (šume, poluprirodna područja i poljoprivredna područja) u regionalnim okruženjima okoliša u Hrvatskoj.• Razviti sustave ranog upozoravanja za poljoprivredu i šumarstvo temeljene na meteorološkim podacima gotovo u stvarnom vremenu i kratkoročnim predikcijama fenoloških reakcija.Projekt se temelji na postavljenim hipotezama:• Je li moguće procijeniti dugoročne klimatske i antropogene učinke na kopnenu površinu pod vegetacijom iz prostorno-vremenskih podataka promatranja površine Zemlje?• Je li moguće odrediti stupanj prilagodbe pojedinog vegetacijskog tipa na klimatske promjene? Koje su vrste šuma i poljoprivrednih kultura najmanje, a koje najviše pogođene klimatskim promjenama?• Je li moguće dati kratkoročnu predikciju utjecaja klime na tipove vegetacije?]]></summary_hr><summary_en><![CDATA[Satellite remote sensing presents an inevitable global source of synoptic data that enable retrospective characterization into the dynamics of the vegetated land surface and associated biogeophysical and biogeochemical processes. Remote sensing enables acquisition both of long-term observations and information about the intra-seasonal dynamics of vegetation, or “land surface phenology”. Since there are no existing nationwide studies with very high spatial sensitivity of the land cover changes as a consequence of historical political and socio-economic trends, this project project will use recent advances in state-of-the-art predictive modelling and machine learning. In that sense, the main scientific research objectives of the project are:• To develop technical framework, based on the long-term Earth observation and advanced data processing, statistical and machine learning algorithms, for evaluation of the spatio-temporal land cover dynamics due to institutional changes and regional impacts of global environmental change.• To provide results that enable precise evaluation of the impact, vulnerability and adaptation capacity of the main vegetation types and land-use classes (forests, semi natural areas and agriculture areas) across the regional environmental settings in Croatia.• To develop early warning systems for agriculture and forestry based on near-real-time meteorological data and short-term forecasting of phenological responses.The project is based on stated hypotheses:• Is it possible to assess the long-term climatic and anthropogenic effects on the spatio-temporal vegetated land surface earth observation data?• Is it possible to determine degree of adaptation of each vegetation type to climate change? Or simplified. Which forest type and agricultural crops are least and most affected by climate change?• Is it possible to provide short-term forecasting of climate impacts on vegetation classes?]]></summary_en></project><project>
<id>15544</id><title_hr><![CDATA[Inovativne metode istraživanja u svrhu procjene potencijala geotermalne energije i pohrane toplinske energije]]></title_hr><title_en><![CDATA[Innovative exploration methods for geothermal potential assessment and energy storage]]></title_en><user_id>5498</user_id><user_firstLast_name>Tomislav Kurevija</user_firstLast_name><svouser_id>866539</svouser_id><svouser_firstLast_name>Mitja Janža</svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-4206</code><acronim><![CDATA[InnoGeoPot]]></acronim><duration>15.02.2024 - 14.02.2028</duration><status>U tijeku</status><financ_value>182.729,59 eur</financ_value><scie_area_hr>Tehničke znanosti, Prirodne znanosti, </scie_area_hr><scie_area_en>Technological sciences, Natural sciences, </scie_area_en><scie_field_hr>Rudarstvo, nafta i geološko inženjerstvo, Geologija, </scie_field_hr><scie_field_en>Mining, petroleum and geological engineering, Geology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Rudarsko-geološko-naftni fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mining, Geology and Petroleum Engineering]]></institution_en><team_members_id>13694, 12942, 865167, 872970, 858322, </team_members_id><team_members_names><![CDATA[Marija Macenić, Luka Perković, Kristijan Posavec, Vedrana Filipović, Marko Sinčić, ]]></team_members_names><keywords_hr><![CDATA[geotermalna energija, srednje-duboki BHE, pohrana toplinske energije - BTES, revitalizacija bušotina, termodinamičko-hidrauličko modeliranje]]></keywords_hr><keywords_en><![CDATA[geothermal energy, medium-deep BHE, thermal energy storage - BTES, well revitalization, thermal-hydrualic modelling]]></keywords_en><summary_hr><![CDATA[Uz stalno povećanje broja instaliranih sustava bušotinskih izmjenjivača topline (BHE) u Europi, prepoznata je potreba i iskorištavanje toplinske energije sadržane u dubljim horizontima podzemnih slojeva tla i stijena. U odabranim pilot područjima još nije provedeno istraživanje geotermalnog potencijala na dubinama između 200 i 500 m koristeći bušotinske izmjenjivače topline. Ovim projektom namjerava se uspostaviti geološko-hidrogeološko-termodinamički model korištenjem podataka prikupljenih tijekom bušenja dubokih bušotina u odabranim područjima (neobrađeni geološki i hidrogeološki podaci) kao i praćenjem stvarnih podataka iz polja plitkih geotermalnih izmjenjivača u radu te određivanjem toplinskih prinosa sustava. Nadalje, iskorištavanje plitkog i srednje dubokog geotermalnog potencijala može se proširiti i na primjenu skladištenja toplinske energije u stijeni bušotinskim izmjenjivačima (BTES), kao i na mogućnost iskorištavanja geotermalnog potencijala revitalizacijom napuštenih bušotina. Razvijeni geološko-hidrogeološko-geotermalni model će biti važan jer će osigurati bolji uvid u plitki i srednje duboki geotermalni potencijal područja, te definiranje područja gdje je moguće koristiti podzemlje za BTES. Također će se razmotriti procjena geotermalnog potencijala kroz revitalizaciju napuštenih bušotina. Područje istraživanja u Hrvatskoj obuhvaća šire područje grada Zagreba, grada Ljubljane i pograničnog područja između SI Slovenije i JI Hrvatske.Trilateralna suradnja Hrvatske, Švicarske i Slovenije na ovom projektu dovest će do formiranja međunarodne istraživačke skupine koja će se baviti karakterizacijom podzemlja i razvojem tehnologije u području geotermalne energije. Za odabrana pilot područja pravovremeni DSS za plitko i srednje duboko korištenje geotermalne energije bit će vrlo koristan alat koji će osigurati učinkovitije i održivije korištenje geotermalne energije.]]></summary_hr><summary_en><![CDATA[With the constant increase in the number of installed borehole heat exchangers (BHE) systems in Europe, the need and utilization of thermal energy contained in deeper geological layers has been recognized. In selected urban and rural pilot areas in Croatia and Slovenia, the investigation of geothermal potentials at medium-depths, between 200 & 500 m, via BHE has not yet been carried out. The proposed research intends to establish different scale geological-hydrogeological-thermal models using data collected during drilling of deep wells in selected areas (geological and hydrogeological raw data) as well as monitoring real data from shallow geothermal borehole field in operation to determine heat rejection/extraction rates. Furthermore, the exploitation of shallow and medium-deep geothermal potential can be extended to the application of borehole thermal energy system (BTES), as well as the possibility of exploiting geothermal potentials by revitalizing abandoned wells via deep closed-loop BHE. The developed geological-hydrogeological-geothermal model, along with a decision-support system (DSS), is important as it will provide a better insight into the shallow and medium-deep geothermal potential of the studied pilot areas as well as defining areas where it is possible to use BTES. Also, the evaluation of the geothermal potential through the revitalization of abandoned wells will be considered. The research area in Croatia covers the wider area of the city of Zagreb, the city of Ljubljana and the transboundary area between NE Slovenia and SE Croatia.Croatian, Swiss and Slovenian trilateral cooperation on this project will lead to forming an international research group dealing with subsurface characterization and technology development in the field of geothermal energy. For selected pilot areas timely DSS for shallow and medium-deep geothermal energy utilization will be a very useful tool that will ensure more efficient and sustainable geothermal energy utilization.]]></summary_en></project><project>
<id>15544</id><title_hr><![CDATA[Inovativne metode istraživanja u svrhu procjene potencijala geotermalne energije i pohrane toplinske energije]]></title_hr><title_en><![CDATA[Innovative exploration methods for geothermal potential assessment and energy storage]]></title_en><user_id>5498</user_id><user_firstLast_name>Tomislav Kurevija</user_firstLast_name><svouser_id>866543</svouser_id><svouser_firstLast_name>Jannis Epting</svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-4206</code><acronim><![CDATA[InnoGeoPot]]></acronim><duration>15.02.2024 - 14.02.2028</duration><status>U tijeku</status><financ_value>182.729,59 eur</financ_value><scie_area_hr>Tehničke znanosti, Prirodne znanosti, </scie_area_hr><scie_area_en>Technological sciences, Natural sciences, </scie_area_en><scie_field_hr>Rudarstvo, nafta i geološko inženjerstvo, Geologija, </scie_field_hr><scie_field_en>Mining, petroleum and geological engineering, Geology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Rudarsko-geološko-naftni fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mining, Geology and Petroleum Engineering]]></institution_en><team_members_id>13694, 12942, 865167, 872970, 858322, </team_members_id><team_members_names><![CDATA[Marija Macenić, Luka Perković, Kristijan Posavec, Vedrana Filipović, Marko Sinčić, ]]></team_members_names><keywords_hr><![CDATA[geotermalna energija, srednje-duboki BHE, pohrana toplinske energije - BTES, revitalizacija bušotina, termodinamičko-hidrauličko modeliranje]]></keywords_hr><keywords_en><![CDATA[geothermal energy, medium-deep BHE, thermal energy storage - BTES, well revitalization, thermal-hydrualic modelling]]></keywords_en><summary_hr><![CDATA[Uz stalno povećanje broja instaliranih sustava bušotinskih izmjenjivača topline (BHE) u Europi, prepoznata je potreba i iskorištavanje toplinske energije sadržane u dubljim horizontima podzemnih slojeva tla i stijena. U odabranim pilot područjima još nije provedeno istraživanje geotermalnog potencijala na dubinama između 200 i 500 m koristeći bušotinske izmjenjivače topline. Ovim projektom namjerava se uspostaviti geološko-hidrogeološko-termodinamički model korištenjem podataka prikupljenih tijekom bušenja dubokih bušotina u odabranim područjima (neobrađeni geološki i hidrogeološki podaci) kao i praćenjem stvarnih podataka iz polja plitkih geotermalnih izmjenjivača u radu te određivanjem toplinskih prinosa sustava. Nadalje, iskorištavanje plitkog i srednje dubokog geotermalnog potencijala može se proširiti i na primjenu skladištenja toplinske energije u stijeni bušotinskim izmjenjivačima (BTES), kao i na mogućnost iskorištavanja geotermalnog potencijala revitalizacijom napuštenih bušotina. Razvijeni geološko-hidrogeološko-geotermalni model će biti važan jer će osigurati bolji uvid u plitki i srednje duboki geotermalni potencijal područja, te definiranje područja gdje je moguće koristiti podzemlje za BTES. Također će se razmotriti procjena geotermalnog potencijala kroz revitalizaciju napuštenih bušotina. Područje istraživanja u Hrvatskoj obuhvaća šire područje grada Zagreba, grada Ljubljane i pograničnog područja između SI Slovenije i JI Hrvatske.Trilateralna suradnja Hrvatske, Švicarske i Slovenije na ovom projektu dovest će do formiranja međunarodne istraživačke skupine koja će se baviti karakterizacijom podzemlja i razvojem tehnologije u području geotermalne energije. Za odabrana pilot područja pravovremeni DSS za plitko i srednje duboko korištenje geotermalne energije bit će vrlo koristan alat koji će osigurati učinkovitije i održivije korištenje geotermalne energije.]]></summary_hr><summary_en><![CDATA[With the constant increase in the number of installed borehole heat exchangers (BHE) systems in Europe, the need and utilization of thermal energy contained in deeper geological layers has been recognized. In selected urban and rural pilot areas in Croatia and Slovenia, the investigation of geothermal potentials at medium-depths, between 200 & 500 m, via BHE has not yet been carried out. The proposed research intends to establish different scale geological-hydrogeological-thermal models using data collected during drilling of deep wells in selected areas (geological and hydrogeological raw data) as well as monitoring real data from shallow geothermal borehole field in operation to determine heat rejection/extraction rates. Furthermore, the exploitation of shallow and medium-deep geothermal potential can be extended to the application of borehole thermal energy system (BTES), as well as the possibility of exploiting geothermal potentials by revitalizing abandoned wells via deep closed-loop BHE. The developed geological-hydrogeological-geothermal model, along with a decision-support system (DSS), is important as it will provide a better insight into the shallow and medium-deep geothermal potential of the studied pilot areas as well as defining areas where it is possible to use BTES. Also, the evaluation of the geothermal potential through the revitalization of abandoned wells will be considered. The research area in Croatia covers the wider area of the city of Zagreb, the city of Ljubljana and the transboundary area between NE Slovenia and SE Croatia.Croatian, Swiss and Slovenian trilateral cooperation on this project will lead to forming an international research group dealing with subsurface characterization and technology development in the field of geothermal energy. For selected pilot areas timely DSS for shallow and medium-deep geothermal energy utilization will be a very useful tool that will ensure more efficient and sustainable geothermal energy utilization.]]></summary_en></project><project>
<id>15547</id><title_hr><![CDATA[Oleogelovi kao nutritivno poboljšanje čokolade i krem-proizvoda]]></title_hr><title_en><![CDATA[Oleogels as Nutritive Improvers of Chocolate and Sweet Spreads]]></title_en><user_id>4578</user_id><user_firstLast_name>Đurđica Ačkar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-1960</code><acronim><![CDATA[ONICS]]></acronim><duration>29.12.2023 - 28.12.2027</duration><status>U tijeku</status><financ_value>194.809,12 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Prehrambena tehnologija, </scie_field_hr><scie_field_en>Food technology, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Prehrambeno-tehnološki fakultet]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Food Technology]]></institution_en><team_members_id>7262, 5093, 921, 13465, 865890, 865877, 865875, 865876, 24554, 24555, 869815, 869908, </team_members_id><team_members_names><![CDATA[Ivana Flanjak, Jurislav Babić, Mirta Benšić, Svjetlana Škrabal, Ivana Lončarević, Malgorzata Starowicz, Malgorzata Wronkowska, Daniela Paulik, Veronika Barišić, Marija Banožić, Dario Šarić, Andrea Karlović, ]]></team_members_names><keywords_hr><![CDATA[Nusproizvodi prehrambene industrije, vlakna, proteini, masti, oleogelovi, čokolada, krem-proizvod]]></keywords_hr><keywords_en><![CDATA[Food industry byproducts, fiber, protein, fat, oleogels, chocolate, sweet spread]]></keywords_en><summary_hr><![CDATA[Projekt je nastavak istraživanja provedenog na UIP-2017-05-8709 Primjena kakaove ljuske u proizvodnji čokolade i  srodnih proizvoda, u kojem je kakaova ljuska primijenjena kao zamjena za šećer i/ili kakao u čokoladi i srodnim proizvodima. Cilj ovog projekta je istražiti mogućnost zamjene masti u čokoladi i krem-proizvodima primjenom oleogelova na bazi nusproizvoda prehrambene industrije (kakaova ljuska i pljevica pira, sirutka) i proteina boba te lješnjakovog, suncokretovog ulja i kokosove masti. Također, ispitat će se mogućnost izolacije vlakana iz biljnih nusproizvoda i njihova primjena u oleogelovima za proizvodnju čokolade i krem-proizvoda.Kakaova ljuska, pljevica pira, sirutka i proteini boba, kao i izolirana vlakna,  modificirat će se primjenom visokonaponskog električnog pražnjenja kako bi im se poboljšala svojstva vezanja ulja. Provest će se detaljna karakterizacija modificiranih sirovina, oleogelova, čokolade i krem-proizvoda te će se procijeniti nutritivno poboljšanje krajnjih proizvoda.U sklopu projekta planira se izrada doktorskog rada, većeg broja diplomskih radova, objava minimalno 3 znanstvena rada u Q1 i Q2 časopisima, kao i veći broj sudjelovanja na skupovima kako bi se diseminirali rezultati, koji će doprinijeti široj primjeni nusproizvoda prehrambene industrije, oleogelova na bazi vlakana i proteina, kao i rješenjima za nutritivno poboljšanje konditorskih proizvoda. Na kraju projekta izradit će se brošura s rezultatima koja će biti predstavljena na završnoj konferenciji.]]></summary_hr><summary_en><![CDATA[The project is the extension of the research conducted within UIP-2017-05-8709 Application of cocoa husk in the production of chocolate and chocolate-like products, in which cocoa shell was used as a substitute for sugar and/or cocoa in chocolate and chocolate-like products. The aim of this research is to examine the potential of fat substitution in chocolate and sweet spreads through application of oleogels based on food industry by-products (cocoa shell, spelt chaff, whey) and broad bean proteins, with hazelnut, sunflower and coconut oil. Isolation of fiber from cocoa shell and spelt chaff, and their application in oleogels for chocolate and sweet spreads will be explored as well. Cocoa shell, spelt chaff, whey and broad bean proteins, and fiber will be modified by high-voltage electrical treatment in order to enhance their oil binding capacity. Modified raw material, oleogels, chocolates and sweet spreads will be characterized in detail, and nutritional improvement of the final products will be assessed. A PhD thesis, a larger number of graduate theses, minimum of 3 scientific articles in scientific journals (Q1 and Q2), a larger number of presentations at scientific congresses will disseminate results, aid in more extensive use of food industry byproducts, use of fiber- and protein-based oleogels, and in nutritional improvement of confectionery products. At the end of the project, brochure with the results will be published and presented at the final conference.]]></summary_en></project><project>
<id>15550</id><title_hr><![CDATA[Inovativni vinifikacijski postupci u funkciji povećanja biološkog i nutritivnog potencijala vina i nusproizvoda vinifikacije autohtonih i introduciranih sorti vinove loze]]></title_hr><title_en><![CDATA[Innovative vinification procedures for increasing the biological and nutritional potential of wine and vinification by-products of autochthonous and introduced grape varieties]]></title_en><user_id>6511</user_id><user_firstLast_name>Sanja Radeka</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-9128</code><acronim><![CDATA[VinNutriVit]]></acronim><duration>31.12.2023 - 30.12.2027</duration><status>U tijeku</status><financ_value>198.958,13 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Institut za poljoprivredu i turizam]]></institution_hr><institution_en><![CDATA[Institute of Agriculture and Tourism in Poreč]]></institution_en><team_members_id>7005, 3037, 5191, 855671, 865018, 23704, 866281, 12468, 13660, 23717, 25498, 869603, 868657, 872826, </team_members_id><team_members_names><![CDATA[Marijan Bubola, Igor Palčić, Marina Lukić, Ena Bestulić, Fumica Orbanić, Mato Drenjančević, Jasmina Ranilovic, Valentina Pavić, Tomislav Plavša, Toni Kujundžić, Sara Rossi, Erik Matić, Lovro Mihajlović, Laura Banović, ]]></team_members_names><keywords_hr><![CDATA[inovativni vinifikacijski postupci, autohtone i introducirane sorte, vino, nusproizvodi vinifikacije, biološki potencijal, nutritivna svojstva]]></keywords_hr><keywords_en><![CDATA[innovative vinification procedures, autochthonous and introduced varieties, wine, vinification by-products, biological potential, nutritive properties]]></keywords_en><summary_hr><![CDATA[Inovativne tehnologije, poput ultrazvuka (sonikacija), usprkos visokoj učinkovitosti u ekstrakciji fenolnih, aromatskih i nutritivnih spojeva, relativno malo se koriste u vinarstvu. Stoga bi njihova primjena u vinarskoj proizvodnji mogla postati važna tehnološka inovacija za ubrzavanje relativno sporih procesa kao što je maceracija masulja. Također, proizvodnja vina neizbježno generira nusproizvode vinifikacije, koji se uobičajeno smatraju otpadom, iako se zbog visokog sadržaja polifenola, vlakana, antioksidativnog i antimikrobnog potencijala, mogu učinkovito koristiti u prehrambenom sektoru kao funkcionalna hrana. Cilj ovog projekta je istražiti kako inovativne vinifikacijske tehnologije u proizvodnji vina autohtonih hrvatskih sorti Malvazije istarske i Terana, te introduciranih sorti Graševine i Merlota,  mogu utjecati na bioaktivni, antimikrobni i nutritivni potencijal dobivenih vina i nusproizvoda, te istražiti mogućnosti njihove primjene u protektivne i prehrambene svrhe. U proizvodnji vina navedenih sorti primijenit će se tretmani sonikacije masulja različitih frekvencija ultrazvučnih valova i duljina trajanja. Proizvedena vina i nusproizvodi podvrgnut će se analizi aromatskih i fenolnih spojeva, antioksidacijskog i nutritivnog potencijala, te će biti senzorno ocjenjena. Podaci o kemijskom, bioaktivnom i nutritivnom sastavu vina i nusproizvoda proizašli iz ovog istraživačkog projekta, omogućit će bolje razumijevanje kemijskih i biokemijskih procesa do kojih dolazi primjenom određenih vinifikacijskih tehnika, dok će senzorna analiza proizvedenih vina i nusproizvoda vinifikacije potvrditi njihovu organoleptičku prihvatljivost i zdravstvenu ispravnost s ciljem dobivanja novog proizvoda. Budući da se neadekvatno zbrinuta komina grožđa smatra ekološkim problemom, mogućnosti iskorištenja nusproizvoda vinifikacije u nutritivne i protektivne svrhe, omogućilo bi dobivanje proizvoda s dodanom vrijednošću u kontekstu kružnog, održivog gospodarstva.]]></summary_hr><summary_en><![CDATA[Innovative technologies, such as ultrasound (sonication), despite their high efficiency in extracting phenolic, aromatic and nutritional compounds, are rarely used in winemaking. Therefore, their application in wine production could become an important technological innovation for speeding up relatively slow processes such as grape maceration. Wine production inevitably generates vinification by-products, which are usually considered waste, although due to the high content of polyphenols, fiber, antioxidant, and antimicrobial potential, they can be effectively used in the food sector as functional food. The aim of this project is to investigate the effect of innovative vinification technologies when producing wines from autochthonous Croatian varieties Malvazija istarska and Teran, and introduced varieties Graševina and Merlot, on the bioactive, antimicrobial and nutritional potential of the resulting wines and by-products. Moreover, the aim is to explore the possibilities of their application in protective and nutritional purposes. Sonication treatments of different frequencies and durations of ultrasonic waves will be applied in the production of wines of the mentioned varieties.  Aromatic and phenolic compounds, antioxidant and nutritional potential and sensory profile of the produced wines will be analysed. Data on chemical, bioactive and nutritional composition of wine and by-products will enable a better understanding of the chemical and biochemical processes that occur through the application of certain vinification techniques, while the sensory analysis of the produced wines and vinification by-products will confirm their organoleptic acceptability and safety with the aim of obtaining a new product. Since inadequately managed grape pomace is considered an ecological problem, the possibility of using vinification by-products for nutritional and protective purposes would provide products with added value in the context of a circular, sustainable economy.]]></summary_en></project><project>
<id>15553</id><title_hr><![CDATA[Ekološki prihvatljivo suzbijanje ambrozije kombinacijom reduciranih doza herbicida i fenolnih kiselina ]]></title_hr><title_en><![CDATA[Environmental friendly control of Ambrosia artemisiifolia with a combination of reduce herbicide dose and phenolic acids ]]></title_en><user_id>865587</user_id><user_firstLast_name>Maja Šćepanović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-6639</code><acronim><![CDATA[PHENOMENA]]></acronim><duration>21.12.2023 - 20.12.2027</duration><status>U tijeku</status><financ_value>179.933,58 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Agronomski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Agriculture]]></institution_en><team_members_id>866483, 866486, 866490, 866495, 19317, 12868, 19319, 866489, 869577, 4884, 873185, 20375, 873925, </team_members_id><team_members_names><![CDATA[Valentina Šoštarčić, Aurelio Scavo, Gaetano Pandino, SARA LOMBARDO, Ivana Pajač Živković, Darija Lemić, Helena Virić Gašparić, Dragana Šunjka, Laura Pismarović, Mirna Mrkonjic Fuka, Meng Hao, Irina Tanuwidjaja, Petra Gregurić, ]]></team_members_names><keywords_hr><![CDATA[Ambrozija, fenolne kiseline, reducirane doze herbicida, soja, kukuruz, korisna mikrobiota, korisna fauna tla]]></keywords_hr><keywords_en><![CDATA[Common ragweed, phenolic acids, reduced doses of herbicides, soybean, maize, beneficial microbiota, beneficial soil fauna]]></keywords_en><summary_hr><![CDATA[Produkcijom alergene peludi ambrozija predstavlja javno-zdravstveni problem, a velikom zastupljenosti u proljetnim usjevima ekonomsku važnu korovnu vrstu čije se suzbijanje obavlja primjenom sintetičkih herbicida. EU agrarna politika zbog onečišćenja tla, vode i zraka te smanjenja bioraznolikosti snažno zahtjeva poljoprivredu manje ovisnu o pesticidima. Dodatno, i u RH su utvrđene rezistentne populacije ambrozije u usjevima soje i kukuruza, što posljedično značajno otežava uzgoj ovih ratarskih kultura. Stoga su nužno potrebna održiva rješenja u suzbijanju ambrozije poput primjene smanjenih doza herbicida u kombinaciji sa prirodnim spojevima. Glavni cilj projekta je istražiti mogućnost primjene fenolnih kiselina u kombinaciji sa reduciranim dozama herbicida u suzbijanju ambrozije. U prethodnim in vitro istraživanjima selektirane su fenolne kiseline s potencijalnom inhibicije klijanja ambrozije. Predloženim projektom utvrditi će se dinamika klijanja ambrozije pri različitim koncentracijama fenolnih kiselina te utvrditi sadržaj karotenoida, fenola, antioksidacijsku aktivnost i klorofilnu fluorescenciju u biljkama ambrozije folijarno tretirane fenolnim kiselinama. S ciljem utvrđivanja učinka fenolnih kiselina prema indikatorima biološke plodnosti tla, u in vitro i in situ istraživanjima utvrditi će se minimalno inhibitorna, minimalno baktericidna/fungicidna te minimalno insekticidna koncentracija fenolnih kiselina prema odabranim predstavnicima mikrobiote i faune tla. Selektivna doza fenolnih kiselina prema ne-ciljnim organizmima će se potom kombinirati sa reduciranim dozama šest herbicida usjeva kukuruza i soje kako bi se utvrdila učinkovita doza svakog herbicida na ambroziju i potom usporedila sa samostalnom (bez dodataka fenolnih kiselina) primjenom istih herbicida. Zaključno, utvrditi će se selektivnost kukuruza i soje prema kombinaciji reducirane doze herbicida i fenolne kiseline učinkovitoj za suzbijanje ambrozije, a selektivnoj prema korisnim organizmima u tlu.]]></summary_hr><summary_en><![CDATA[Common ragweed, which produces allergenic pollen, is a public health problem and an economically important weed species that is usually controlled with synthetic herbicides. EU agricultural policy calls for less pesticide-dependent agricultural production due to soil, water, and air pollution and biodiversity reduction. In addition, resistant populations of ragweed have been discovered in soybeans and corn in Croatia, significantly hindering the cultivation of these important agricultural crops. Therefore, alternative and sustainable solutions for ragweed control are needed, such as the use of reduced herbicides dose in combination with natural compounds. The main objective of the project is to investigate the possibility of using phenolic acids in combination with a reduced herbicide dose. Previous in vitro studies have selected three phenolic acids that can inhibit common ragweed germination. The proposed project will determine the common ragweed germination dynamics at different concentrations of phenolic acids and determine the amount of carotenoids, phenols, antioxidant activity, and chlorophyll fluorescence in phenolic acid treated plants. To determine the selective effect of phenolic acids on indicators of soil biological fertility, the minimum inhibitory, minimum bactericidal/fungicidal, and minimum insecticidal concentrations of phenolic acids for selected representatives of soil microbiota and fauna will be determined by in vitro and in situ studies. The selective dose of phenolic acids to nontarget organisms will then be combined with reduced doses of the six maize and soybean herbicides studied to determine the effective dose of each herbicide on ragweed and compare it to independent (without phenolic acid addition) application of the same herbicides. Finally, maize and soybean selectivity will be determined after combining a reduced herbicide dose + phenolic acid, which is effective against ragweed and selective for beneficial soil organisms.]]></summary_en></project><project>
<id>15555</id><title_hr><![CDATA[Karakterizacija prirođenog imunosnog odgovora na citomegalovirus u jajniku]]></title_hr><title_en><![CDATA[Characterizing innate immune responses to cytomegalovirus in the ovaries]]></title_en><user_id>4682</user_id><user_firstLast_name>Vanda Juranić Lisnić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-2324</code><acronim><![CDATA[CIRCO]]></acronim><duration>29.12.2023 - 28.12.2027</duration><status>U tijeku</status><financ_value>199.064,31 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Medicine]]></institution_en><team_members_id>19694, 23779, 17754, 865893, </team_members_id><team_members_names><![CDATA[Jelena Tomac, Marija Mazor, Jelena Železnjak, Magdalena  Medved, ]]></team_members_names><keywords_hr><![CDATA[jajnici, folikuli jajnika, citomegalovirus, NK stanice, ILC1, prirođena imunost]]></keywords_hr><keywords_en><![CDATA[Ovaries, ovarian follicles, cytomegalovirus, NK cells, ILC1, innate immunity]]></keywords_en><summary_hr><![CDATA[Citomegalovirus (CMV) inficira većinu svjetske populacije, uključujući žene reproduktivne dobi. Infekcija tijekom trudnoće glavni je uzrok urođenih mana ili ranog gubitka trudnoće, međutim njegov utjecaj na reproduktivne organe ostao je uglavnom neistražen. Prvi smo proveli prvo detaljno istraživanje patogeneze infekcije CMV-a u jajnicima koristeći mišji model i pokazali da CMV lako inficira jajnike. Infekcija je lokalizirana u žuta tijela i stromu, te rezultira smanjenom količinom hormona progesterona što dovodi do gubitka trudnoće. Zanimljivo, mehanizmi prirođenog imunog odgovora štite folikule jajnika od infekcije, a jednu od ključnih uloga u tome igraju i NK i ILC1. Navedene stanice specijalizirane su za ranu detekciju i eliminaciju patogena i tumora, a pacijenti sa nedostatkom NK stanica pate od čestih infekcija herpesvirusima. Navedene stanice također igraju važnu ulogu u trudnoći u posteljici, međutim njihov fenotip i funkcija u jajnicima je u potpunosti neistražena. Stoga u sklopu ovog projekta predlažemo istraživanje ovih stanica multiparametrijskom protočnom citometrijom i scRNASeq metodom. Koristit ćemo i panel transgeničnih miševa kako bismo mogli razlikovati ulogu stanica NK od ILC1 te ulogu pojedinačnih komponenti njihovog arsenala (npr citokina, citolitičkih molekula i receptora). Razumijevanje biologije u funkcija ovih stanica u široko prihvaćenom i korištenom animalnom modelu prvi je korak prema translaciji ovog projekta u kliničke i studije na ljudima.]]></summary_hr><summary_en><![CDATA[Cytomegalovirus (CMV) infects a major portion of human population, including women of reproductive age. Infection during pregnancy is the major cause of congenital birth defects or early pregnancy loss, however its impact on reproductive organs remained largely unexplored until recently. We were the first to perform a detailed investigation of the pathogenesis of the CMV infection in the ovaries utilizing mouse model and have demonstrated that CMV readily infects the ovaries. The infection is localized to corpora lutea and stroma, resulting in severely diminished progesterone levels which might lead to early pregnancy loss. Interestingly, multiple layers of the innate immune system prevent the virus from infecting ovarian follicles and thereby endangering fertility in general. We demonstrated that innate lymphocytes (NK cells and ILC1) play a major role in the follicle protection. NK and ILC1 cells are innate immune lymphocytes specialized in early detection and elimination of viruses and tumors. Individuals lacking NK cells suffer from recurrent herpesviral infections. NK/ILC1 cells play major roles in pregnancy maintenance in decidua but their phenotype and function has not yet been investigated in ovaries. Therefore, in this project we propose an in-depth characterization of ovarian NK and ILC1 cells utilizing multiparametric flow cytometry and single cell RNASeq. We will also utilize a panel of transgenic mice to tease apart the contribution of NK cells and ILC1 cells, their various cytokines, cytolytic molecules and Ly49H receptor. Understanding the biology and general functions of innate immune cells in a widely accepted and often employed mouse model is an important first step towards translation of this research to human patients.]]></summary_en></project><project>
<id>15558</id><title_hr><![CDATA[Stvaranje klimatski-pametnih tla: Ublažavanje procesa erozije i degradacije tla u hrvatskim poljoprivrednim sustavima]]></title_hr><title_en><![CDATA[Forming climate - smart soils: Mitigation of soil erosion and degradation processes in Croatian agricultural systems]]></title_en><user_id>20011</user_id><user_firstLast_name>Igor Bogunović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-5692</code><acronim><![CDATA[FORMclimaSOIL]]></acronim><duration>18.12.2023 - 17.12.2027</duration><status>U tijeku</status><financ_value>198.982,15 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Agronomski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Agriculture]]></institution_en><team_members_id>23536, 7706, 22749, 866512, </team_members_id><team_members_names><![CDATA[Marija Galić, Ivica Kisić, Paulo Pereira, Sebastiano Trevisani, ]]></team_members_names><keywords_hr><![CDATA[Održivo gospodarenje, sekvestracija C, degradacija tla, Ciljevi održivog razvoja, plodnost tla, organska tvar, utjecaj na okoliš, CO2]]></keywords_hr><keywords_en><![CDATA[Sustainable management, C sequestration, Land degradation, Sustainable development goals, Soil fertility, organic matter, Environmental impact, CO2 ]]></keywords_en><summary_hr><![CDATA[Tla pod usjevima zauzimaju 12 % kopnene površine što čini ovaj način korištenja zemljišta važnim po pitanju regulacije klime zbog jedinstvene uloge tla kao spremnika. Europska unija (EU) pokreće nekoliko politika (npr. Zeleni dogovor, Zakon o klimi, Strategija bioraznolikosti 2030., Od polja do stola) koje će transformirati poljoprivredne sustave u kojima će upravljanje ugljikom (C) imati ključnu ulogu u postizanju klimatskih ciljeva EU, neutralnosti degradacije zemljišta te druge UN-ove ciljeve održivog razvoja. U ovom trenu, hrvatski poljoprivrednici još uvijek nemaju implementiranu dobru poljoprivrednu praksu što dovodi do ubrzanog gubitka C i degradacije zemljišta. Projektni prijedlog omogućit će dugoročna istraživanja praksi gospodarenja tlom uporabom daljinskih i istraživanja na terenu na kvalitetu tla, produktivnost, sekvestraciju C i degradaciju zemljišta. To će omogućiti bolju perspektivu o utjecajima praksi gospodarenja na svojstva tla i hidrološki odgovor. Korištenjem tehnika daljinskog istraživanja omogućit će se digitalna analiza terena visoke razlučivosti i pružiti potencijal za razvoj jednog ili skupa modela. Kombinirane tehnike za determinaciju erozije tla u Hrvatskoj pedosferi nisu još korištene. Stoga su ciljevi: 1) ispitati prakse upravljanja tlom (konzervacijske i konvencionalne) i njihov utjecaj na kvalitetu tla, sekvestraciju C i prinos; 2) odrediti hidrološku reakciju i godišnju eroziju tla pod različitim praksama upravljanja; 3) upotrijebiti daljinska i terenska istraživanja u kako bi se ustvrdila erozija te omogućilo bolje razumijevanje njezinog procesa. Trenutni projekt omogućuje korak naprijed u ovom ekološkom i poljoprivrednom problemu. Potrebne su brze mjere za uspostavu održivijih praksi koje će smanjiti izravne i neizravne utjecaje konvencionalne poljoprivrede. To je ključno za postizanje ciljeva EU (npr. Zeleni dogovor ili Strategija bioraznolikosti) te za postizanje UN-ove neutralnosti degradacije zemljišta.]]></summary_hr><summary_en><![CDATA[Croplands cover 12% of the world&#39;s land surface making this land use important for climate regulation issues due to their unique role as a sink. European Union (EU) launch several policies (e.g. Green Deal, Climate law, Biodiversity Strategy 2030, Farm to Fork) which will transform the agricultural systems and carbon (C) management will play a key role in achieving the EU&#39;s climate goals, land degradation neutrality and other UN Sustainable Development Goals (SDG). In this moment, Croatian farmers still do not have implemented good agricultural practices that accelerates the C losses and land degradation.  Project proposal will enable a long-term proximal sensing vs. field-based monitoring investigations of soil management impact on soil quality, productivity, C sequestration and land degradation. This will allow a better perspective on the impacts of management on soil properties and the hydrological response. Using proximal sensing techniques will provide high-resolution digital terrain analysis and the potential for model development as well as model ensemble strategies. Using combined techniques for determination of soil erosion was missing in Croatian pedosphere. Therefore, goals are: 1) to test different soil management practices (conservation vs. conventional) and their impact on soil quality, C sequestration and crop yield; 2) to determine the hydrological response and soil loss rates under different management practices; 3) to use proximal sensing vs. field-based monitoring to understand soil erosion processes. Present project enables step forward in this environmental and agricultural problem. Urgent measures are needed to establish more sustainable practices that will reduce site and off-site impacts of conventional agriculture. This is key to meeting targets for EU (e.g. Green Deal or Biodiversity Strategy) and to achieve UN’s Land Degradation Neutrality.]]></summary_en></project><project>
<id>15567</id><title_hr><![CDATA[Potpuno održivi elementi drvenih konstrukcija bez ljepila i metalnih spajala]]></title_hr><title_en><![CDATA[Fully sustainable timber structures elements without adhesives and metal connectors]]></title_en><user_id>19348</user_id><user_firstLast_name>Vlatka Rajčić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-1800</code><acronim><![CDATA[ECO-WOOD Structures]]></acronim><duration>20.12.2023 - 19.12.2027</duration><status>U tijeku</status><financ_value>198.951,49 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Građevinarstvo, Arhitektura i urbanizam, Temeljne tehničke znanosti, Interdisciplinarne tehničke znanosti, </scie_field_hr><scie_field_en>Civil engineering, Architecture and Urban Environment, Basic engineering sciences, Interdisciplinary technological sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Građevinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Civil Engineering]]></institution_en><team_members_id>26418, 22453, 4319, 19926, 2730, 3178, 866511, 866518, 866516, 866527, 866536, 866528, 866519, 866534, 20244, 873013, 872728, </team_members_id><team_members_names><![CDATA[Nikola Perković, Ivan Duvnjak, Bojan Milovanović, Ivana Carević, Damir Varevac, Jurko Zovkić, Alar Just Just, Eero Tuhkanen, Petr Kuklik, Ivica Župčić, IVAN ŽULJ, Tomislav Skušić, Martin Hataj, Jan Pošta Pošta, Jure Barbalić, Jelena Galić, Bruno Zadravec, ]]></team_members_names><keywords_hr><![CDATA[održiva gradnja, drvene konstrukcije, lamelirano drvo, križno-lamelirano drvo, densificirani trnovi, varenje drvenih trnova]]></keywords_hr><keywords_en><![CDATA[sustainable building, timber structures, laminated timber, cross-laminated timber, densified dowels, timber dowels welding ]]></keywords_en><summary_hr><![CDATA[Korištenje drva kao materijala u građevinarstvu jedna je od temeljnih strategija održivog razvoja. Osim što dugoročno skladište apsorbirani ugljikov dioksid, drvene konstrukcije imaju prednost brze i jednostavne predgotovljene gradnje, ponovne uporabe i potpunog recikliranja. Danas, lamelirani drveni elementi zasnovani su na lijepljenju ili korištenju metalnih spajala. Ljepila, kao i metal, ograničavaju trajnost i požarnu otpornost drva, onemogućavaju potpuno rastavljanje i recikliranje konstrukcije te ostavljaju snažan ugljični otisak. Razvoj drvne tehnologije rezultirao je novim, potpuno održivih tehnikama lameliranja dasaka. Za razliku od standardiziranih metoda, uporaba trnova od densificiranog drva, kao i zavarenih trnova od tvrdog drva, omogućava proizvodnju visokokvalitetnih elemenata, a da se pri tom ne koriste adhezivi ili metalna spajala. Kod densifikacije drva, osnovni materijal postiže bolja materijalna svojstva primjenom privremenog povećanja tlaka, čime se trajno zgušnjava praznina između staničnog materijala. Kod zavarenih drvenih trnova, visokofrekventno trljanje dviju površina uzrokuju trenje i toplinu koji omekšavaju, a zatim vezuju lignin, mehanički spajajući stanični materijal. Ove tehnike imaju potencijal za primjenu ne samo na lamelirane linijske, već i na križno-lamelirane plošne element, koji su ključni za izgradnju više-etažnih građevina. Suradnjom domaćih i međunarodnih istraživača kroz laboratorijska ispitivanja, numeričke analize i procjenu životnog ciklusa, istražile bi se karakteristike drvenih elemenata lameliranih na potpuno ekološki način. Konačni rezultat bili bi točno definirani principi oblikovanja, kao i matematički izrazi za proračun mehaničke otpornosti i stabilnosti te uporabivosti ovakvog tipa elemenata. Ujedno, istraživanje bi rezultiralo osnovama za proizvodnju potpuno održivih građevinskih elemenata čije daljnje usavršavanje i proizvodnju, zbog prihvatljivih cijena ulaganja, u znatnoj mjeri mogu ostvariti i domaće tvrtke.]]></summary_hr><summary_en><![CDATA[The use of wood as building material is one of the fundamental strategies of sustainable development. In addition to long-term storage of absorbed carbon dioxide, timber structures have an advantage of fast and simple prefabricated construction, reuse and complete recycling. Today, laminated timber elements are based on gluing and use of metal fasteners. Adhesives, as well as metal, limit the durability and fire resistance, make it impossible to completely disassemble and recycle the structure, and leave a strong carbon footprint. Development of wood technology resulted in new, fully sustainable techniques for laminating boards. In contrast to standardized methods, the use of dowels made of densified wood, as well as hardwood welded dowels, enables the production of high-quality elements without using adhesives or metal fasteners. In wood densification, the base material achieves better properties by applying a temporary increase in pressure, which permanently densifies the void between the cellulars. In welded wooden dowels, high frequency rubbing of the two surfaces causes friction and heat that soften and then bond the lignin, mechanically joining the cellular material. These techniques have the potential to be applied not only to linear laminated girders or columns, but also to cross-laminated plate elements, which are crucial for construction of multi-storey buildings. Cooperation of domestic and international researchers through laboratory tests, numerical and life cycle analyses, the characteristics of timber elements laminated in completely ecological way would be investigated. The result would be precisely defined assembly principles, as well as mathematical expressions for design of this type of elements. At the same time, the research would result in the production basis of fully sustainable construction elements, which further improvement and production, due to acceptable investment prices, can be achieved to a considerable extent by domestic companies.]]></summary_en></project><project>
<id>15573</id><title_hr><![CDATA[Potopljena neolitička nalazišta u podmorju hrvatskog dijela Jadrana]]></title_hr><title_en><![CDATA[Undersea Neolithic sites in the Croatian Adriatic]]></title_en><user_id>6111</user_id><user_firstLast_name>Mate Parica</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-3893</code><acronim><![CDATA[SubNeo]]></acronim><duration>18.12.2023 - 17.12.2027</duration><status>U tijeku</status><financ_value>55.013,60 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Arheologija, </scie_field_hr><scie_field_en>Archeology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zadru]]></institution_hr><institution_en><![CDATA[University of Zadar]]></institution_en><team_members_id>5521, 866421, 866113, 7534, 866472, 866406, 5824, 865312, </team_members_id><team_members_names><![CDATA[Irena Radić Rossi, Kristina Horvat Oštrić, Mladen Pešić, Domagoj Perkić Perkić, Doris Vidas, Katarina Jerbić, Maja Miše, Eduard Visković, ]]></team_members_names><keywords_hr><![CDATA[Podvodna arheologija, neolitik, istočni Jadran, potopljene prapovijesne konstrukcije, podizanje morske razine]]></keywords_hr><keywords_en><![CDATA[Underwater archaeology, Neolithic, eastern Adriatic, submerged prehistoric structures, sea level rise]]></keywords_en><summary_hr><![CDATA[U posljednjih nekoliko godina, u podmorju hrvatskog dijela Jadrana, prvi put su otkriveni neolitički naseobinski elementi iz vremena neolitika ispod današnje morske razine. Predlagatelj projekta je dosadašnjim istraživanjima i rekognosciranjima otkrio pet dosada nepoznatih potopljenih neolitičkih lokaliteta koji obuhvaćaju vrijeme od otprilike 6000 do 4600 godina prije Krista, a ostatci naseobinskih konstrukcija ili komunikacija nalaze se okvirno između 6 i 4 metra ispod današnje morske razine. Uz standardni repertoar neolitičkih nalaza, na spomenutim lokalitetima, unutar morskog mulja je dobro očuvan organski materijal.  Preliminarni rezultati istraživanja Lokaliteta Soline, te podmorskih pregleda ostalih lokaliteta, pokazuju golemi potencijal u istraživanju ove vrste nalazišta. Najvažniji lokalitet projekta su Soline na otoku Korčuli iznimno je dobro sačuvano naselje iz vremena kasnog neolitika, oko 4800. godine prije Krista. Očuvana je suhozidna konstrukcija poligonalne obale promjera 100 metara, mnoštvo zidova unutar naselja, bogat neolitički arheološki materijal, te očuvani organski ostatci. Projektom je pradviđen razvoj inovativnih metoda istraživanja i interpretacije deponiranja arheološkog materijala unutar nalazišta, konstruktivnih elemenata nalazišta, razumijevanje razlika geoloških tvorevina od ljudskog utjecaja u sklopu nalazišta, eksperimentalna istraživanja deponiranja slojeva, erozije crvenice, trošenja vapnenca i  sl. Ovim projektom dao bi se značajan doprinos poznavanju morske razine u neolitiku. Prije svega,  smještaj neolitičkih slojeva i konstrukcija u odnosu na današnju morsku razinu odrediti će dinamiku podizanja morske razine između 8000 i 6000 godina prije sadašnjosti, i ono najvažnije, reakciju neolitičkih zajednica na poplavljivanje obalnih naselja. Metodologija istraživanja projektnog prijedloga podijeljena je na nekoliko skupina: podmorska arheološka iskopavanja, eksperimentalna iskopavanja, terenski pregled, te različite analize.]]></summary_hr><summary_en><![CDATA[During the last few years, unprecedented finds of residential elements from the Neolithic have been made in the Croatian part of the Adriatic, below current sea level. Through research and archaeological prospecting, the applicant has discovered five previously unknown submerged Neolithic sites that span the time period from 6000 to 4600 years BC, where the remains of residential structures or communications are located between 6 and 4 metres below current sea level. In addition to the standard repertoire of Neolithic finds, there is well-preserved organic material in the sea mud.  The preliminary results of research on the Soline site, as well as underwater surveys of the others, show the enormous potential in the research of this type of site. The most important site of the project is Soline (Korčula), an exceptionally well-preserved settlement from the late Neolithic, around 4800 BC. The dry-stone construction of the polygonal seafront with a diameter of 100 metres, many walls inside the settlement, rich Neolithic archaeological material and organic remains have been preserved. The project anticipates the development of innovative methods of research and interpretation of the deposition of archaeological material within the site and constructional elements of the site, the understanding of differentiation between geological formations and human influence within the site, experimental research on the deposition of layers, erosion of red soil and wear of limestone. This project would make a contribution to our understanding of the sea level in the Neolithic. The placement of  layers and structures in relation to today’s sea level will determine the dynamics of sea level rise between 8000 and 6000 years ago and, the reaction of Neolithic communities to the flooding of settlements. The research methodology of the project proposal is divided into several groups: underwater archaeological excavations, experimental excavations, field surveys and various analyses.]]></summary_en></project><project>
<id>15579</id><title_hr><![CDATA[Sit Tibi Terra Levis:  formule i fraze s nadgrobnih spomenika antičke Liburnije i Japodije]]></title_hr><title_en><![CDATA[Sit Tibi Terra Levis: Formulae and Phrases from Funerary Monuments of Ancient Liburnia and Japodia]]></title_en><user_id>254</user_id><user_firstLast_name>Anamarija Kurilić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-7548</code><acronim><![CDATA[STTL]]></acronim><duration>18.12.2023 - 17.12.2027</duration><status>U tijeku</status><financ_value>64.264,38 eur</financ_value><scie_area_hr>Humanističke znanosti, Interdiciplinarne znanosti, </scie_area_hr><scie_area_en>Humanities, Interdisciplinary scientific area, </scie_area_en><scie_field_hr>Arheologija, Povijest, Geografija, </scie_field_hr><scie_field_en>Archeology, History, Geography, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zadru]]></institution_hr><institution_en><![CDATA[University of Zadar]]></institution_en><team_members_id>2723, 866341, 29314, 6305, 866473, 22550, 22505, 12395, 871532, 867618, </team_members_id><team_members_names><![CDATA[Zrinka Serventi, Francisca Feraudi-Gruenais, Nedim Tuno, Kornelija Giunio A., Anja Ragolic, Fran Domazetović, Ivan Maric, Ante Šiljeg, Muamer Đidelija, Matteo Pola, ]]></team_members_names><keywords_hr><![CDATA[Rimska epigrafija, Liburnija, Japodija, digitalna humanistika, GIS analize, klasična arheologija, rimske nekropole i pogrebni rituali, tanatologija]]></keywords_hr><keywords_en><![CDATA[Roman epigraphy, Liburnia, Iapodia, Digital humanities, GIS analyses, Classical archaeology, Roman cemeteries and funerary rituals, Tanatology]]></keywords_en><summary_hr><![CDATA[Predloženo istraživanje je temeljno istraživanje kojim će se na osnovi proučavanja nadgrobnih spomenika, njihovih sadržaja i korelacije s ostalim relevantnim izvorima (arheološkima, jezičnima, povijesnima i drugima) unaprijediti poznavanje rimske povijesti i arheologije, a osobito iz aspekata svakodnevice, običaja i rituala te postupka akulturacije i romanizacije. Očekuje se da će se moći ustanoviti i pojedine prostorne i vremenske specifičnosti istraživanih područja i/ili mikroregija.Kombinirano istraživanje pojavnosti formula i fraza do sada još nije napravljeno pa se i u tome očituje inovativnost ovog projektnog prijedloga.Tijekom istraživanja primijenit će se razne metode koristeći interdisciplinarni i multidisciplinarni pristup. Temeljna metodologija pripada znanstvenom području humanističkih znanost. Na njih će se nadovezivati metode digitalne humanistike općenito te digitalne epigrafije u užem smislu, kao i metode prostorne analize karakteristične za geografska i kartografska istraživanja.Očekivani rezultati su višestruki, počevši od stvaranja temeljito istraženog korpusa građe i njegovog open access objavljivanja. U pogledu analize građe, očekuje se prije svega postizanje boljeg razumijevanja pogrebnih rituala te odnosa živih i mrtvih u rimskom svijetu, pri čemu očekujemo određene razlike između bolje i jače romaniziranih zona (kao što je Liburnija) i manje romaniziranih (kao što je Japodija). Postignuti rezultati bit će referentni i za sva ostala područja rimskih pokrajina jer još nigdje nisu provedena ista ili slična istraživanja. Rezultati projekta predstavit će se i široj javnosti, osobito kroz razne vidove vizualizacija, storytellinga, javnih predavanja i sličnog jer je izuzetno važno podijeliti znanstveni napredak sa cjelokupnim stanovništvom, a ne samo znanstvenom zajednicom. ]]></summary_hr><summary_en><![CDATA[The proposed research is a fundamental research which, based on the study of tombstones, their contents and correlation with other relevant sources (archaeological, linguistic, historical etc.), will improve the knowledge of Roman history and archaeology, especially from the aspects of everyday life, customs and rituals and the process of acculturation and Romanization. It is expected that it will be possible to establish certain spatial and temporal particularities of the researched areas and/or microregions.A combined research on the occurrence of formulas and phrases has not been done so far, which testify to the innovativeness of this project proposal.During the research, various methods will be applied using an interdisciplinary and multidisciplinary approach. The basic methodology belongs to the humanities, more precisely, to the historical science. In addition, methods of digital humanities in general and digital epigraphy in a narrower sense, as well as methods of spatial analysis characteristic of geographical and cartographic research, will also be used.The expected results are multiple, starting with the creation of a thoroughly researched epigraphic corpus and its open access publication. We expect to achieve a better understanding of funeral rituals and the relationship between the living and the dead in the Roman world; also, we expect to detect certain differences between better and stronger Romanized zones (such as Liburnia) and less Romanized ones (such as Iapodia). The achieved results will be a reference for all other Roman provincial areas because such a research has not yet been conducted anywhere.The results of the project will be presented to the general public, especially through various types of visualisations, storytelling, public lectures and the like, because it is extremely important to share scientific progress with the entire population, not just the scientific community.]]></summary_en></project><project>
<id>15584</id><title_hr><![CDATA[Blizu-predmetna daljinska istraživanja za preciznu inventuru šuma]]></title_hr><title_en><![CDATA[Close-Range Remote Sensing for Precision Forest Inventory]]></title_en><user_id>1275</user_id><user_firstLast_name>Ivan  Balenović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-9246</code><acronim><![CDATA[CLOSER-FORINVENT]]></acronim><duration>18.12.2023 - 17.12.2027</duration><status>U tijeku</status><financ_value>197.800,00 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Šumarstvo, </scie_field_hr><scie_field_en>Forestry, </scie_field_en><institution_hr><![CDATA[Hrvatski šumarski institut]]></institution_hr><institution_en><![CDATA[Croatian Forest Research Institute]]></institution_en><team_members_id>6352, 26146, 866220, 19806, 3207, 3478, 24107, 874058, </team_members_id><team_members_names><![CDATA[Krunoslav Indir, Nikola Zorić, Andro Kokeza, Anita Simic Milas, Damir Medak, Mario Miler, Luka Jurjević, Albert Seitz, ]]></team_members_names><keywords_hr><![CDATA[Blizu-predmetna daljinska istraživanja, precizna inventura šuma, terestričko lasersko skeniranje, mobilno lasersko skeniranje, UAV, ULS]]></keywords_hr><keywords_en><![CDATA[Close-range remote sensing, precision forest inventory, terrestrial laser scanning, mobile laser scanning, UAV, ULS]]></keywords_en><summary_hr><![CDATA[Predloženi projekt CLOSER-FORINVENT predstavlja nastavak 3D-FORINVENT-a u pogledu daljnjeg testiranja i razvoja prikladnih metodoloških pristupa različitih tehnologija blizu-predmetnih daljinskih istraživanja (CR-RS) za primjenu u inventurI šuma. Glavna ideja je provesti temeljito testiranje različitih najsuvremenijih CR-RS tehnologija za preciznu inventuru šuma u glavnim i najvažnijim hrvatskim šumskim sastojinama (hrast lužnjak, obična bukva) različitih strukturnih i terenskih karakteristika. Istraživanje će uključivati testiranje različitih procesa prikupljanja podataka, različitih algoritama i metoda obrade te različitih skupova podataka prikupljenih korištenjem različitih senzora. Također će se istražiti mogućnost fuzije podataka različitih senzora. Sve to, zajedno s prikupljanjem vrlo preciznih terenskih referentnih podataka, provesti će se kako bi se procijenila točnost i prikladnost različitih CR-RS tehnologija u raznim zadacima inventure šuma, kao što su: generiranje DTM-a, detekcija i segmentacija pojedinačnog stabla, određivanje položaja stabla, klasifikacija vrste stabla i procjena glavnih atributa (prsni promjer, visina, volumen) na razini stabla, plohe i sastojine. Uz to, projekt CLOSER-FORINVENT testirat će integraciju, tj. kombinaciju CR-RS podataka i dostupnih nacionalnih podataka daljinskih istraživanja s ciljem povećanja procjena na veća šumska područja wall-to-wall kartiranjem. Trenutno nedostaju takva detaljna, komparativna istraživanja koja se bave učinkovitošću i primjenjivošću različitih naprednih CR-RS tehnologija u inventuri šuma, posebno u kompleksnom šumskom okruženju, kao što su mješovite, listopadne, šume različitih strukturnih karakteristika. Stoga je od velike važnosti za šumarsku znanost provesti istraživanje kojime će razviti i preporučiti najprikladnije metode za moguću primjenu CR-RS tehnologija u operativnoj inventuri šuma.]]></summary_hr><summary_en><![CDATA[The proposed CLOSER-FORINVENT project represents a continuation of 3D-FORINVENT regarding further testing and development of suitable methodological approaches of different close-range remote sensing (CR-RS) technologies for the forest inventory applications. The main idea is to perform thorough testing of a different state of-the-art CR-RS technologies for precision forest inventory in the main and the most important Croatian forest stand types (pedunculate oak, common beech) of different structural and terrain characteristics. The research will include testing of a different data acquisition protocols, different processing algorithms and methods, and various datasets collected from different sensors. The fusion of different sensors will also be investigated. All these, along with the collection of highly accurate ground reference data, will be performed to evaluate the accuracy and suitability of different CR-RS technologies in a various forest inventory task, such as: digital terrain model generation, individual tree detection and segmentation, determination of tree positions, tree species classification, and estimation of the main attributes at tree-, plot- and stand-level. In addition, the CLOSER-FORINVENT project will test the integration, i.e., data fusion of CR-RS data and available national remote sensing data aiming to upscale estimates to a larger forest area by wall-to-wall mapping. So far, there have been a lack of such detailed comparison studies dealing with performance and applicability of different high-end CR-RS technologies in forest inventory, especially in complex forest environment, such as mixed, deciduous, temperate forests of different structural characteristics. Therefore, it is of great importance for forestry science to perform research which will develop and recommend the most suitable methods for the possible application of CR-RS in operational forest inventory.]]></summary_en></project><project>
<id>15592</id><title_hr><![CDATA[Arhitektura i kultura stanovanja u Zagrebu 1880.–1940.]]></title_hr><title_en><![CDATA[Architecture and Housing Culture in Zagreb in the period 1880-1940]]></title_en><user_id>4910</user_id><user_firstLast_name>Irena Kraševac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-9503</code><acronim><![CDATA[ARHZAG]]></acronim><duration>18.12.2023 - 17.12.2027</duration><status>U tijeku</status><financ_value>117.750,00 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Povijest umjetnosti, </scie_field_hr><scie_field_en>Art history, </scie_field_en><institution_hr><![CDATA[Institut za povijest umjetnosti]]></institution_hr><institution_en><![CDATA[Institute of Art History, Zagreb]]></institution_en><team_members_id>23359, 4649, 3667, 20184, 866124, 4836, 23828, 6365, 866210, 3208, 866090, 871387, </team_members_id><team_members_names><![CDATA[Katarina Horvat Levaj, Tamara Bjažić Klarin, Ivana Mance Cipek, Marina Bagarić, Vanja Brdar Mustapić, Branko Ostajmer, Jana Vukić, Ivana Haničar Buljan, Irena Šimić, Boris Dundović, Katarina Horvat, Luka Hornung, ]]></team_members_names><keywords_hr><![CDATA[Zagreb, stambena arhitektura, tipologija, stil, atribucija, građanska kultura, valorizacija, obnova]]></keywords_hr><keywords_en><![CDATA[Zagreb, residential architecture, typology, style, attribution, urban culture, valorisation, conservation]]></keywords_en><summary_hr><![CDATA[Predmet istraživanja je stambena arhitektura Donjega grada – njezine tipološke, morfološke, stilske i konstruktivne značajke te umjetničko-obrtna oprema koja ukazuje na kulturu stanovanja, realiziranu u razdoblju od prvog velikog zagrebačkog potresa 1880. do 1940., razdoblja u kojem se Zagreb transformira u kulturno, privredno, trgovačko i novčarsko sredisˇte Hrvatske s najvisˇim sociokulturnim aspiracijama građanstva. Ovaj korpus je zajedno s proširenjem gradskog stanovanja, reprezentativnim potezom trgova i perivoja Zelene potkove, ujedno je i glavna urbana supstanca Zagreba koja mu je dala naličje srednjoeuropske metropole i kreirala njegov identiteta. Oba su produkt visoke kulture gradogradnje i stanovanja – striktno zacrtanih pravila (građevni red, regulatorne osnove), zajedničkog djelovanja urbanista i graditelja tj. arhitekata koji ih sukreiraju i poštuju te investitora – građanske klase željne javne promocije. U gospodarstvenim i kulturnim strukturalnim promjenama koje su tezˇile metropolizaciji, Zagreb se oslanja na Beč i druge srednjoeuropske uzore. Obnova Donjega grada nakon potresa 2020. godine suocˇila nas je s problemom nedovoljne istraženosti i valorizacije njegove arhitektonske baštine – slabim poznavanjem pojedinacˇnih arhitektonskih ostvarenja, atributivnim problemima vezanim uz arhitekte i graditelje, te daljnjom devastacijom izvornih pročelja i interijera. Ti se problemi najjasnije čitaju u urbanom tkivu gradskih blokova, sačinjenih od pojedinačnih primjera stambene arhitekture, već pri osnovnoj analizi dostupne arhivske i dokumentacijske građe. Projekt će se provoditi kroz interdisciplinarno povijesno-umjetničko, povijesno i sociološko istraživanje stambene arhitekture na odabranom području zagrebačkog Donjega grada.]]></summary_hr><summary_en><![CDATA[The subject of research is the residential architecture of the Lower Town – its typological, morphological, stylistic and structural features as well as art and crafts decorations pointing to the residential culture realized in the period starting from the first great Zagreb earthquake in 1880 to 1940, a period during which Zagreb was transformed into a cultural, economic, commercial and monetary centre of Croatia. This urban whole together with the expansion of urban housing – a representative stretch of squares and the so-called Green Horseshoe intended for recreation and social interaction – is also the main urban substance of Zagreb forming it into a Central European metropolis and creating its identity. Both elements resulted from a high culture of urban planning and housing, strictly defined rules (building order, regulatory bases), joint action of urban planners and builders, that is, architects and master builders who co-created and respected those rules, and investors who belonged to a civil class eager for public promotion. The reconstruction of the Lower City after the earthquake 2020 has faced us with the problems resulting from insufficient research and valorization of architectural heritage, poor knowledge about individual architectural commissions and projects. Original formas features of the buildings, such as facades and interiors, were exposed to further devastation. The preliminary analysis of the available archival material and documentation has indicated that these problems most persist in the urban fabric of city blocks made up of individual examples of residential architecture. The current state of its architectural heritage does not represent the culture of the epoch during which it was created, but rather a very specific local way of dealing with it, which inevitably leads to a disappearance of various cultural layers and &#39;&#39;historicity&#39;&#39;, which are the symbols of the national development analogous to the European efforts of the same epoch.]]></summary_en></project><project>
<id>15594</id><title_hr><![CDATA[Biofortifikacija krmiva selenom u proizvodnji malih preživača]]></title_hr><title_en><![CDATA[Selenium biofortified feed in small ruminant production]]></title_en><user_id>3585</user_id><user_firstLast_name>Josip Novoselec</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-3803</code><acronim><![CDATA[SeRumBiofort]]></acronim><duration>18.12.2023 - 17.12.2027</duration><status>U tijeku</status><financ_value>176.587,00 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, Biotehnologija, Interdisciplinarne biotehničke znanosti, </scie_field_hr><scie_field_en>Agriculture, Biotechnology, Interdisciplinary biotechnical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Fakultet agrobiotehničkih znanosti Osijek]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Agrobiotechnical Sciences in Osijek]]></institution_en><team_members_id>2833, 3594, 7747, 3626, 3611, 22713, 29487, 866394, 870425, </team_members_id><team_members_names><![CDATA[Zvonko Antunović, Željka Klir Šalavardić, Zdenko Lončarić, Zvonimir Steiner, Mislav Đidara, Danijela Samac, Mario Ronta, Nina Čebulj-Kadunc Čebulj-Kadunc, Joanna Szpunar, ]]></team_members_names><keywords_hr><![CDATA[biofortifikacija, selen, mali preživači, mlijeko, meso ]]></keywords_hr><keywords_en><![CDATA[biofortification, selenium, small ruminants, milk, meat]]></keywords_en><summary_hr><![CDATA[U zahtjevnim i izazovnim vremenima u kojima živimo, humana populacija je opterećena mnogobrojnim problemima, vezanim za nedostatak vremena za mnoge pa i osnovne, normalne životne potrebe. Raste svijest o važnosti zdrave prehrane te je sveprisutna potraga za zdravim namjernicama, provjerene sljedivosti, onih s dodanom vrijednošću, na kraju onih funkcionalnih, proizvedenih na „prirodan“ način, koje pridonose očuvanju, poboljšanju i unapređenju zdravlja i kvalitete života ljudi, a bez štetnog utjecaja na okoliš i klimu općenito. To je cilj projekta SeRumBiofort, gdje se uz minimalan učinak na okoliš želi proizvesti osnovne namjernice (meso i mlijeko) s dodatnom vrijednošću koje bi imale pozitivan učinak na zdravlje ljudi. Razvijeni su brojni načini uklanjanja istih ali utvrđeno je da hranidbom životinja krmivima s optimalnom koncentracijom Se ili prehranom ljudi s namjernicama s optimalnom koncentracijom Se mogu zaobići, riješiti broji metabolički problemi i unaprijediti zdravlje životinja i ljudi. Biofortifikacijom osnovnih, najvažnijih krmiva u životinja sa selenom (kukuruz i soja) anorganskim selenovim gnojivom (natrij selenatom) cilj je podiči koncentraciju selena u navedenim kulturama te dobiti organski oblik selena završnom proizvodu zrnu. Hrnidba malih preživača krmnim smjesama sastavljenih od biofortificirane kukuruze i soje s povećanom koncetracijom selena (organski oblik) omogućit će lakše usvajanje selena u malih preživača (transplacentarni prijenos), uklanjanje svih metaboličko proizvodnih problema vezanih za njegov nedostatak i na kraju proizvodnja mlijeka, mesa s povećanom- optimalnom koncentracijom selena (organski oblik) čijom će konzumacijom benificjeni učinak imati i ljudi. Meso i mlijeko s pvećanom koncentracijom selena (organskog)  može se nazvati s dodanom vrijednošću. Vrijednost navedenih proizvoda valorizirala bi se kroz njihovu cijenu, a koristi bi imali ovčari kozari i krajnji korisnici ljudi.]]></summary_hr><summary_en><![CDATA[In the demanding and challenging times in which we live, the human population is burdened with numerous problems, related to the lack of time for many basic, normal life needs. Nevertheless, awareness of the importance of a healthy diet is growing, and there is a ubiquitous search for healthy products, with verified traceability, those with added value, finally those functional, produced in a &#39;&#39;natural&#39;&#39; way, which contribute to the preservation, improvement and advancement of people&#39;s health and quality of life, and without harmful impact on the environment and climate in general. This is the goal of the SeRumBiofort project, where, with a minimal impact on the environment, we want to produce basic products (meat and milk) with added value that would have a positive effect on human health. Feeding animals with feed with an optimal concentration of Se or by feeding people with foods with an optimal concentration of Se, many metabolic problems can be bypassed, and the health of animals and people can be improved. Biofortification of feeds for animals with Se (maize and soy) with inorganic selenium fertilizer aims to increase the concentration of Se in the mentioned cultures and to obtain an organic distribution of selenium in the end product grain. Feeding small ruminants with a feed mixture composed of biofortified corn and soybeans with an increased concentration of Se (organic form) will enable easier absorption of selenium in small ruminants (transplacental transmission), the elimination of all metabolic production problems related to its deficiency, and ultimately the production of milk and meat with an increased - optimal concentration of selenium (organic form) whose consumption will also have a beneficial effect on humans. Meat and milk with an increased concentration of Se (organic) can be called value-added. The value of the mentioned products would be valorized through their price, and the sheep and goat farmers and end users (people) would benefit.]]></summary_en></project><project>
<id>15597</id><title_hr><![CDATA[Intencionalnost i načini postojanja]]></title_hr><title_en><![CDATA[Intentionality and Modes of Existence]]></title_en><user_id>1381</user_id><user_firstLast_name>Davor Pećnjak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-5915</code><acronim><![CDATA[IMEX]]></acronim><duration>31.12.2023 - 30.12.2027</duration><status>U tijeku</status><financ_value>91.251,93 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filozofija, Interdisciplinarne humanističke znanosti, </scie_field_hr><scie_field_en>Philosophy, Interdisciplinary humanities, </scie_field_en><institution_hr><![CDATA[Institut za filozofiju]]></institution_hr><institution_en><![CDATA[Institute for Philosophy in Zagreb]]></institution_en><team_members_id>3485, 19563, 3876, 4870, 13057, 3345, 871175, 873032, </team_members_id><team_members_names><![CDATA[Ljudevit Hanžek, Dušan Dožudić, Gabriela Bašić Hanžek, Tomislav Janović, Ivan Restović, Dario Škarica, Simone Nota, Nino Kadić, ]]></team_members_names><keywords_hr><![CDATA[Apstraktni predmeti, svijest, postojanje, intencionalnost, jezik, logika, um, naturalizam, propozicijski sadržaj, reprezentacija]]></keywords_hr><keywords_en><![CDATA[Abstract Objects, Consciousness, Existence, Intentionality, Language, Logic, Mind, Naturalism, Propositional Content, Representation]]></keywords_en><summary_hr><![CDATA[Projekt ima za cilj istražiti odabrane aspekte odnosa između intencionalnosti i postojanja, kako iz povijesne tako i iz suvremene perspektive, obraćajući posebnu pozornost na njihovu međuovisnost, te izvući zaključke o toj međuovisnosti na temelju istraživanja njenih specifičnih aspekata (kao istraživačkih segmenata projekta).]]></summary_hr><summary_en><![CDATA[The project aims to explore the selected aspects of the relation between intentionality and existence, both from the historical and the contemporary perspectives, paying special attention to the interdependence of the two, and to draw conclusions concerning this interdependence based on the investigation of its specific aspects (as research segments of the project).]]></summary_en></project><project>
<id>15598</id><title_hr><![CDATA[Egzegetski instrumentarij Novoga zavjeta]]></title_hr><title_en><![CDATA[Exegetical instruments of the New Testament]]></title_en><user_id>29424</user_id><user_firstLast_name>Taras Barščevski</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-7093</code><acronim><![CDATA[EGZEGETINSTR]]></acronim><duration>18.12.2023 - 17.12.2027</duration><status>U tijeku</status><financ_value>70.109,53 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Teologija, Filologija, </scie_field_hr><scie_field_en>Theology, Philology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Katolički bogoslovni fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Catholic Faculty of Theology]]></institution_en><team_members_id>29463, 29426, 26621, 29435, 29428, 208139, 855320, 855290, 11227, 866315, 865322, 866520, 5891, </team_members_id><team_members_names><![CDATA[Mario Cifrak, Božidar Mrakovčić, Stipo Kljajić, Anđelo Maly, Silvana Fužinato, Darko Tomašević, Dubravko Turalija, Tomislav Zecevic, Zrinka Jelaska, Nada Babić, Arkadiusz Krasicki, Ivan Benaković, Ivan Majić, ]]></team_members_names><keywords_hr><![CDATA[Biblijske znanosti, egzegeza, biblijski prijevodi, interlinearni prijevod, hrvatska biblijska baština]]></keywords_hr><keywords_en><![CDATA[ Biblical science, Exegesis, Bible Translations, Interlinear Translations, Croatian Biblical Heritage]]></keywords_en><summary_hr><![CDATA[Egzegetski instrumentarij Novoga zavjeta povezuje u jednu kompaktnu cjelinu najosvnovnije i najpotrebnije alate znanstvene biblijske egzegeze: kritički tekst Novog zavjeta NA28, gramatičku analizu grčkog teksta, novi interlinearni grčkohrvatski prijevod, grčko-hrvatski rječnik, konkordanciju Novog zavjeta, interlinearne grčko-hrvatske prijevode osam hrvatskih biblijskih prijevoda Novoga zavjeta: Jeruzalemska Biblija (1994.), Zagrebačka Biblija (1968.), Franjevačka Biblija (2010.), Hrvatski standardni prijevod Biblije, prijevod Šarića (1942. 1943.), prijevod Škarića (1958. - 1961.), prijevod Katančića (1831.) i prijevod Kašića (1636.). Zamišljen je kao kompleksni alat, dostupan putem web preglednika, cilj kojega je učiniti razumljivijim grčki tekst Novoga zavjeta te omogućiti nova egzegetska i lingvistička istraživanja.]]></summary_hr><summary_en><![CDATA[Exegetical Instruments of the New Testament brings together into one compact unit the most basic and necessary tools of scientific biblical exegesis. Those are: a critical text of the Greek New Testament NA28, a grammatical analysis of the Greek text, a new interlinear Greek-Croatian translation, a new Greek- Croatian dictionary, a concordance of the New Testament and interlinear Greek-Croatian translations of eight Croatian biblical translations of the New Testament: Jerusalem Bible (1994), Zagrebačka Bible (1968), Franciscan Bible (2010), Croatian Standard Bible Translation (of soon publication), Šarić (1942 - 1943), Škarić (1958 - 1961), a translation by Katančić (1831) and a translation by Kašić (1636). The Exegetical Instruments of the NT is designed as a complex tool, accessible via a web browser, aimed at making Greek text of the New Testament more comprehensive and facilitating new exegetical and linguistic researches.]]></summary_en></project><project>
<id>15599</id><title_hr><![CDATA[Istraživanje uloge asocijacije u bioaktivnosti antimikrobnih peptida: od mjerenja, modeliranja do dizajna i natrag]]></title_hr><title_en><![CDATA[Investigating the role of association in bioactivity of antimicrobial peptides: from measurements, modeling  to design and back ]]></title_en><user_id>5374</user_id><user_firstLast_name>Larisa Zoranić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2022-10</proposal_call><code>IP-2022-10-8432</code><acronim><![CDATA[ InABioAMP]]></acronim><duration>20.12.2023 - 19.12.2027</duration><status>U tijeku</status><financ_value>133.439,51 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Interdisciplinarne prirodne znanosti, Fizika, Biologija, </scie_field_hr><scie_field_en>Interdisciplinary natural sciences, Physics, Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Science]]></institution_en><team_members_id>17844, 25707, 5478, 866568, 866607, 869772, 855424, </team_members_id><team_members_names><![CDATA[Tomislav Rončević, Matko  Maleš, Alessandro Tossi, Mislav Cvitković, Sabrina Pacor, Anamarija Begić, Iva Stojan, ]]></team_members_names><keywords_hr><![CDATA[antimikrobni peptidi, molekularna dinamika, neuronska mreža, biokarakterizacija, asocijacije]]></keywords_hr><keywords_en><![CDATA[antimicrobial peptides, molecular dynamics, neural network, bio characterisation, associations]]></keywords_en><summary_hr><![CDATA[Antimikrobni peptidi (AMP) kritične su komponente gotovo svih oblika urođenih obrambenih sustava života, služeći kao prva linija obrane protiv invazije patogena u biljkama i životinjama. Kao rezultat toga, oni se opsežno istražuju, s fokusom na njihov potencijal kao novih antiinfektivnih lijekova, osobito u kontekstu sve veće otpornosti bakterija na lijekove, što je jedan od velikih izazova našeg vremena. Predloženo istraživanje započet će s dizajniranim ili prirodnim AMP-ovima te kombiniranjem strukturnih i dinamičkih svojstava dobivenih simulacijom molekularne dinamike s biološkom i biofizičkom karakterizacijom ovih peptida u prisutnosti modelnih membrana, i s njihovom aktivnošću na stvarnim membranama u mikrobnih ili stanica domaćina, unaprijedit će razumijevanje odnosa struktura-funkcija i odabrati AMP-ove s potencijalom za kliničku primjenu. Projekt također ima za cilj stvoriti novi program za dizajniranje i karakterizaciju AMP-ova korištenjem pristupa neuronske mreže. Glavna linija istraživanja bit će otkrivanje načina djelovanja povezanog sa samoudruživanjem peptida koji je iza opažene aktivnosti i toksičnosti. Ovim radom pružit će se mogućnosti za jačanje veze između teorijskog i eksperimentalnog rada u Splitu i stavljanje u upotrebu neke od nove opreme nabavljene u nedavnom infrastrukturnom projektu, kao i za uspostavljanje daljnje suradnje s međunarodnim laboratorijima. Projekt će također unaprijediti kvalitetu istraživanja u Splitu, donoseći nove istraživačke interese i novu metodologiju.]]></summary_hr><summary_en><![CDATA[Antimicrobial peptides (AMPs) are critical components of almost all forms of life&#39;s innate defence systems, serving as a first line of defence against invading pathogens in plants and animals. As a result, they are being extensively researched, with a focus on their potential as novel anti-infective drug leads, particularly in the context of emerging drug resistance in bacteria, which is one of the great challenges of our time. Starting with designed or naturally occurring AMPs, the proposed study will advance understanding of the structure-function relationship and identify AMPs with potential for clinical application by combining structural and dynamic properties obtained through molecular dynamics simulation with the biological and biophysical characterization of these peptides in the presence of model membranes and measurements of their activity on real membranes in microbial or host cells. The project also aims to create a new program for designing and characterising AMPs using a neural network approach. The main line of research will be to discover the mode of action related to peptide self-assembly behind the observed activity and toxicity. This work will provide opportunities to strengthen the connection between theoretical and experimental work in Split, put in use some of the new equipment acquired in the recent infrastructure project, and establish further cooperation with international laboratories. The project will also advance the quality of research in Split, bringing new research interests and new methodology. ]]></summary_en></project><project>
<id>15652</id><title_hr><![CDATA[Endotelna disfunkcija, upala i oksidacijski stres u kardiokirurških bolesnika]]></title_hr><title_en><![CDATA[Endothelial dysfunction, inflammation and oxidative stress in patients undergoing cardiac surgery ]]></title_en><user_id>25359</user_id><user_firstLast_name>Vlatka Sotošek</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IPS</proposal_type><proposal_call>2023-02</proposal_call><code>IPS-2023-02-9650</code><acronim><![CDATA[EDIOS]]></acronim><duration>01.11.2023 - 31.10.2026</duration><status>U tijeku</status><financ_value>135.466,00 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Kliničke medicinske znanosti, Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Clinical sciences, Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Medicine]]></institution_en><team_members_id>23488, 25462, 2695, 866680, 866681, </team_members_id><team_members_names><![CDATA[Lara Batičić , Božena Ćurko-Cofek, Gordana Laškarin, Danijel Knežević, Aleksandra Ljubačev, ]]></team_members_names><keywords_hr><![CDATA[endotelni glikokaliks, upala, oksidacijski stres, kardiokirurgija, intenzivno liječenje]]></keywords_hr><keywords_en><![CDATA[endothelial glycocalyx, inflammation, oxidative stress, cardiac surgery, intensive care]]></keywords_en><summary_hr><![CDATA[Kardiokirurški zahvat visokorizičan je postupak koji se vrlo često izvodi uporabom izvantjelesnog krvotoka (engl. cardiopulmonary baypass, CPB). Disfunkcija vaskularnog endotela, koja sudjeluje u upalnom odgovoru potaknutom kardiokirurškim zahvatom, postala je znanstveni i klinički prioritet. Luminalna površina vaskularnog endotela prekrivena je glikokaliksom koji ima ulogu u održavanju vaskularnog tonusa i propusnosti, mehanosenzaciji, mehanotransdukciji, interakciji krvi i endotelnih stanica, prijenosu signala putem dušikovog oksida, uklanjanju slobodnih kisikovih radikala i homeostazi tekućina. Endotelni glikokaliks (eGC) održava ravnotežu između razgradnje i sinteze koja može biti ugrožena patološkim stanjima. Čini se da su povišene koncentracije produkata razgradnje eGC-a povezane s disfunkcijom organa i lošim ishodom kritično bolesnih pacijenata. Stoga njihova kvantifikacija može biti biomarker za predviđanje stupnja razgradnje eGC-a i posljedične disfunkcije organa. Ishemijsko-reperfuzijska ozljeda, (ne)/pulzirajući CPB, preopterećenje tekućinom ili hipovolemija tijekom kardiokirurških operacija mogu doprinijeti oštećenju eGC-a. Učinci pulsirajućeg u odnosu na nepulsirajući CPB nisu sasvim razjašnjeni. Cilj predloženog projekta je istražiti utjecaj nepulsirajućeg i pulsirajućeg CPB-a na endotelnu disfunkciju, oksidacijski stres i upalni odgovor u kardiokirurških bolesnika prije, tijekom operacije te u ranom poslijeoperacijskom razdoblju. Promjene eGC-a, intenzitet oksidacijskog stresa i jačina upalnog odgovora korelirat će se s anestezijskim i kirurškim postupcima kao i s pojavom poremećaja organskih funkcija, oporavkom bolesnika i ishodom liječenja. Dinamičke promjene eGC-a pratit će se i analizirati (para)klinički kako bi se pronašli kvalitativni i kvantitativni biomarkeri za predviđanje tijeka oporavka bolesnika nakon kardiokirurškog zahvata.]]></summary_hr><summary_en><![CDATA[Cardiac surgery is a high-risk procedure, commonly performed with cardiopulmonary bypass (CPB), which affects the microcirculation, leading to complications in the recovery process. The vascular endothelium dysfunction, involved in the inflammatory response induced by cardiac surgery, became scientific and clinical priority. The luminal surface of the vascular endothelium is covered by the glycocalyx, that plays a role in maintaining vascular tone and permeability, mechanosensation, mechanotransduction, blood-endothelial cell interaction, nitric oxide signal transduction, scavenging reactive oxygens species and fluid homeostasis. The endothelial glycocalyx (eGC) maintains a balance between degradation and synthesis and can be compromised under pathological conditions. Elevated levels of eGC degradation products appear to be associated with organ dysfunction and poor outcome in critically ill patients. Therefore, their quantification may be a biomarker for predicting the degree of eGC dysfunction and organ damage. Ischemia-reperfusion injury, (non)/pulsative CPB, fluid overload, or hypovolemia during cardiac surgery may contribute to eGC depletion. The role of pulsatile vs. nonpulsatile CPB is poorly understood. This project aims to investigate the difference between nonpulsatile and pulsatile CPB on endothelial dysfunction, oxidative stress, and inflammatory response in patients undergoing open heart surgery before and during surgery, and in the early postoperative period. Changes in eGC, the extent of oxidative stress, and the enhancement of the proinflammatory response will be correlated with anesthesia and surgical management, as well as the incidence of organ dysfunction, patient recovery, and outcome. The dynamic changes of eGC will be monitored and analyzed (para)clinically to find qualitative and quantitative biomarkers that could be useful tools for predicting the patient&#39;s recovery course after cardiac surgery.]]></summary_en></project><project>
<id>15661</id><title_hr><![CDATA[Taložna evolucija gornjokrednih dubokomorskih bazena u Dinaridima]]></title_hr><title_en><![CDATA[Sedimentary evolution of Late Cretaceous deep-water basins in the Dinarides]]></title_en><user_id>3166</user_id><user_firstLast_name>Borna Lužar-Oberiter</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IPS</proposal_type><proposal_call>2023-02</proposal_call><code>IPS-2023-02-2683</code><acronim><![CDATA[SECret]]></acronim><duration>01.11.2023 - 31.10.2026</duration><status>U tijeku</status><financ_value>155.631,89 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Geologija, </scie_field_hr><scie_field_en>Geology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>12656, 3083, 865343, 866673, 4030, 19298, 3796, 26206, 13363, 871408, </team_members_id><team_members_names><![CDATA[Alan Moro, Aleksandar Mezga, Iva Olić, Šimun Aščić, Adriano Banak, Krešimir Petrinjak, Duje Kukoč, Sanja Šuica, Zorica Petrinec, Matej Plavac, ]]></team_members_names><keywords_hr><![CDATA[provenijencija, biostratigrafija, gornja kreda, paleocen, siliciklastični sedimenti, karbonatni klastiti, scaglia, Dinaridi]]></keywords_hr><keywords_en><![CDATA[provenance, biostratigraphy, Late Cretaceous, Paleocene, siliciclastics, calciclastics, scaglia, Dinarides]]></keywords_en><summary_hr><![CDATA[Dugotrajna evolucija Dinarida, koja je uključivala više faza intenzivne kompresijske tektonike, proizvela je brojne sinorogenetske bazene. U takvim orogenetskim područjima, gdje su detalji vezani uz geološke događaje često zamaskirani tektonotermalnim promjenama, raščlambom i erozijom, klastični materijal pohranjen unutar sinorogenetskih sedimenata predstavlja nezamjenjiv izvor informacija. Zapravo, tamo gdje su izdizanje i erozija potpuno uklonili određene geološke jedinice, podaci dobiveni analizom takvog klastičnog materijala mogu biti jedini preostali dokaz nekadašnjih događaja. Danas, smješteni uz granicu između unutarnjih i vanjskih Dinarida, ostaci gornjokredno-paleocenskog bazenskog sustava protežu se od Alpsko-Dinaridskog prijelaznog područja u Sloveniji i sjevernoj Hrvatskoj i nastavljaju se glavnim trendom Dinarida kroz Bosnu i Hercegovinu i Crnu Goru. Glavni cilj Hrvatske skupine je prikupiti nove terenske i analitičke podatake o provenijenciji i stratigrafiji siliciklastičnih, kalciklastičnih i pelagičkih-hemipelagičkih naslaga kako bi se omogućilo bolje razumijevanje evolucije gornjokredno-paleocenskog bazenskog sustava u prostoru i vremenu, posebice interakcije između glavnih tektonskih događaja i evolucije bazena, klimatskih promjena i donosa sedimenta, te paleogeografije koja je time rezultirala. To će se postići: 1) sedimentološkom i stratigrafskom analizom pelagičkih-hemipelagičkih i „fliških“ naslaga, 2) petrografskim analizama siliciklastičnog i kalciklastičnog detritarnog materijala, 3) geokemijskim i geokronološkim analizama pojedinih detritarnih teških mineralnih zrna.]]></summary_hr><summary_en><![CDATA[The long-lasting evolution of the Dinarides, which involved multiple phases of intense tectonics produced numerous synorogenic basins. In such orogenic settings, where details regarding geological events are often obscured by tectonothermal overprinting, dismemberment and erosion, clastic material stored within synorogenic sediments represents an indispensable source of information. In fact, where uplift and erosion have completely removed certain geological units, data derived from the analysis of such clastic material may well be the only remaining evidence of past events. Today, situated along the boundary between the internal and external Dinarides, remnants of the Late Cretaceous-Paleocene basin system extend from the Alpine-Dinaride transitional area in Slovenia and Croatia and continue along the main Dinaric trend through Bosnia and Herzegovina and Montenegro. At present, a general lack of adequate dating, in particular the lack of geochronological and geochemical data, as well as biostratigraphic data of basinal deposits of the Dinarides hinders our ability to place precise, reliable constraints on the dynamics of major tectonic phases and the paleogeographic changes that resulted. The main aim of the Croatian team within the project is to gather new field and analytical data from siliciclastic, calciclastic and pelagic-hemipelagic deposits focused on provenance and stratigraphy in order to provide a better understanding of the Late Cretaceous-Paleocene basin system evolution in space and time, particularly the interaction between major tectonic events and basin evolution, changes in climate and sediment supply, as well as resulting paleogeography. This will be achieved by: 1) sedimentary and stratigraphic analysis of pelagic-hemipelagic and “flysch” deposits; 2) petrographic analyses of the siliciclastic and calciclastic detrital material; 3) geochemical and geochronological analyses of individual detrital heavy mineral grains.]]></summary_en></project><project>
<id>15665</id><title_hr><![CDATA[Valorizacija proizvodnih ostataka iz tvornica ulja bazirana na konceptu biorafinerije]]></title_hr><title_en><![CDATA[Valorisation of residues from the vegetable oil industry based on a biorefinery approach]]></title_en><user_id>309</user_id><user_firstLast_name>Marina Tišma</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IPS</proposal_type><proposal_call>2023-02</proposal_call><code>IPS-2023-02-6614</code><acronim><![CDATA[VALREO]]></acronim><duration>02.11.2023 - 01.11.2026</duration><status>U tijeku</status><financ_value>193.351,14 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Biotehnologija, </scie_field_hr><scie_field_en>Biotechnology, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Prehrambeno-tehnološki fakultet]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Food Technology]]></institution_en><team_members_id>408, 1387, 868459, 871180, 872902, </team_members_id><team_members_names><![CDATA[Kristina Mastanjević, Jelena Parlov Vuković, Dora Bjedov, Ida Zahović, Laura Hanić, ]]></team_members_names><keywords_hr><![CDATA[proizvodni ostatci, proizvodnja biljnih ulja, valorizaija, visokovrijedni produkti, enzimi, analiza životkog vijeka]]></keywords_hr><keywords_en><![CDATA[residues, vegetable oil industry, valorisation, value-added products, enzymes, life cycle analysis ]]></keywords_en><summary_hr><![CDATA[Cilj ovog projekta je istražiti mogućnost transformacije postojećih uljara u biorafinerije na način da se proizvodni ostatci koriste za proizvodnju  proizvoda s dodanom vrijednošću i energiju, stvarajući kružnost životnog ciklusa resursa.Motivacija za ovo istraživanje leži u činjenici da je u Euoropskoj uniji u 2022. godini proizvedeno oko 16 milijuna tona biljnog ulja, a očekuje se da će se ta količina povećati na 17,5 milijuna tona do 2031. godine. Tijekom proizvodnje i rafiniranja ulja, dolazi do nastanka različitih vrsta proizvodnih ostataka, kao što su pogače sjemenki uljarica, iskorištena zemlja za izbjeljivanje, sapuni, destilati masnih kiselina, kiselo ulje i drugi.Prvo će se napraviti mapiranje tvornica ulja u Europi, u sklopu čega će se prikupiti podaci o dostupnosti, količini i trenutnom upravljanju proizvodnim ostatcima uljara. Optimizacijom i modeliranjem procesa proučavat će se različiti scenariji za prijelaz industrije ulja u integriranu biorafineriju. Zatim će se provesti istraživanje primjene a) naprednih termo-kemijskih metoda (osobito hidrotermalne obrade), b) bioloških metoda temeljenih na gljivama i c) sinergije dviju metoda korištenjem proizvodnih ostataka iz proizvodnje konopljinog, bučinog i lanenog ulje, posebice pogače, kao modelnih materijala. Tijekom tretmana proizvodit će se i karakterizirati različiti proizvodi, a kako bi se postigla kružnost procesa, istraživat će se mogućnost primjene nastalih proizvoda u različite svrhe. Na kraju će se provesti procjena životnog ciklusa (LCA) dobivenih proizvoda te će se analizirati i kvantificirati utjecaji korištenih tehnologija na okoliš.]]></summary_hr><summary_en><![CDATA[This project aims to explore the possibility of transforming existing vegetable oil industries (VOI) into biorefineries by converting process residues into new value-added products and energy, whereas creating the circularity in the life cycle of resources. The motivation for this research lays in the fact that the vegetable oil industry (VOI) in the EU produced approximately 16 million metric tons of oils in 2022 and this amount is expected to increase to 17.5 million metric tons by 2031. During the oil production and refining, various types of process residues are produced, such as oil seeds cakes (OC), spent bleaching earth (SBE), soapstocks, fatty acid distillates, acid oil, and others. Those materials are mostly unutilized. First, mapping of the VOI in the Europe will be performed, where the data on availability, quantity and current management of residues will be collected. Different scenarios for the transition of VOI into integrated biorefinery will be studied by optimisation approach and process modelling.?Then, an experimental research on a) advanced thermo-chemical methods, b) fungal-based biological methods, and c) synergy of two methods will be done using residual materials from the production of hemp, pumpkin, and flax oil, particularly oil cakes, as a model materials. During the treatment, a variety of the products will be produced and characterized. To close the loop, the advanced use of obtained products?for various applications will be investigated. At the end, a life cycle assessment (LCA) of obtained products will be performed and the environmental impacts of the used technologies will be analysed and quantified. ]]></summary_en></project><project>
<id>15666</id><title_hr><![CDATA[Memorijske strategije i estetike u popularnoj kulturi: murali, film i popularna glazba kao proizvodnja sjećanja]]></title_hr><title_en><![CDATA[Mnemonic Aesthetics and Strategies in Popular Culture: Murals, Film, and Popular Music as Memory Work]]></title_en><user_id>2671</user_id><user_firstLast_name>Vjeran Pavlakovic</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IPS</proposal_type><proposal_call>2023-02</proposal_call><code>IPS-2023-02-5149</code><acronim><![CDATA[MEMPOP]]></acronim><duration>01.11.2023 - 31.10.2026</duration><status>U tijeku</status><financ_value>105.818,40 eur</financ_value><scie_area_hr>Humanističke znanosti, Društvene znanosti, Interdiciplinarne znanosti, </scie_area_hr><scie_area_en>Humanities, Social sciences, Interdisciplinary scientific area, </scie_area_en><scie_field_hr>Interdisciplinarne humanističke znanosti, Informacijske znanosti, Povijest, Znanost o umjetnosti, Etnologija i antropologija, </scie_field_hr><scie_field_en>Interdisciplinary humanities, Information sciences, History, Arts, Ethnology and anthropology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Filozofski fakultet u Rijeci]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>865954, 3739, 782, 870148, 873064, 872846, </team_members_id><team_members_names><![CDATA[Mila Orlić, Diana Grgurić, Boris Ružić, Eric Ušić, Owen Kohl, Rodoljub Jovanović, ]]></team_members_names><keywords_hr><![CDATA[kultura sjećanja, popularna kultura, murali, filmski festivali, popularna glazba]]></keywords_hr><keywords_en><![CDATA[cultural memory, popular culture, murals, film festivals, popular music]]></keywords_en><summary_hr><![CDATA[Popularna kultura predstavlja jedan od najznačajnijih aspekata suvremenih kulturnih i kolektivnih krajobraza sjećanja. Razni oblici popularne kulture, poput proze i poezije, popularne glazbe, filma, stripova i murala – zajedno s različitim platformama na kojima se ti kulturni proizvodi stvaraju, posreduju i konzumiraju – prenose priče o prošlosti i opremaju je bojama, zvukovima i protagonistima. U Hrvatskoj i Sloveniji, kao i u susjednim zemljama, institucionalizirana memorijalizacija prošlosti političkih elita (Drugi svjetski rat, komunizam, ratovi na prostorima bivše Jugoslavije) stremi nametanju hegemonijskih narativa, dok široki spektar popularno-kulturnih proizvoda jačaju ili dovode u pitanje te narative. MEMPOP će provesti inovativno istraživanje memorijskih estetika i strategija popularne kulture (s fokusom na murale, film i popularnu glazbu), te proučiti kako ta praksa proizvodnje sjećanja odozdo funkcionira u odnosu na institucionalizirane krajobraze sjećanja. Rezultati ovog inovativnog i komparativnog istraživanja doprinijet će rastućem polju studija sjećanju kojima se naglašava potreba za istraživanjem kolektivnog pamćenja izvan isključivih domena traume i nostalgije, pritom otkrivajući mehanizme politika sjećanja u popularno-kulturnoj produkciji ne samo u Hrvatskoj i Sloveniji nego i transnacionalno. MEMPOP predlaže pristup mnemoničkom utjecaju popularne kulture iz perspektive participativne popularne kulture kao polja oblikovanja i osporavanja značenja kontekstualiziranih u medijima murala, filma i popularne glazbe. MEMPOP razmatra kulturni i mnemonički utjecaj popularne kulture kao proizvod popularno-kulturnih tekstova, zvukova i vizualnih reprezentacija (mnemonička estetika), kao i procese i agente uključene u proizvodnju, distribuciju i recepciju tih tekstova, zvukova i reprezentacije (mnemotehničke strategije). ]]></summary_hr><summary_en><![CDATA[Popular culture represents one of the most significant aspects of modern cultural and collective memoryscapes. Various manifestations of popular culture, such as prose and poetry, popular music, cinema, comic books, and murals - along with the different platforms where these cultural products are created, mediated, and consumed - transmit stories about the past and equip it with colors, sounds, and protagonists. In Croatia and Slovenia, as well as in neighboring countries, the institutionalized memorialization of the past (World War Two, communism, the wars of Yugoslav dissolution) seeks to impose hegemonic narratives created by the political elites, whereas the broad spectrum of popular-cultural products challenge as well as reinforce those narratives. MEMPOP will conduct pioneering research into the mnemonic aesthetics and strategies of popular culture (focusing on murals, film, and popular music), and how this memory work from below interacts with the institutionalized memoryscape. The results of this innovative and comparative research will add to the growing body of memory studies scholarship that highlights the need to explore collective memory beyond trauma and nostalgia, unpacking the mechanisms of memory politics in popular cultural production not only in Croatia and Slovenia but transnationally as well. MEMPOP proposes to approach the mnemonic impact of popular culture from the perspective of participatory popular-cultural sites of meaning-formation and contestation, formed around the media of murals, film, and popular music. MEMPOP considers the cultural and mnemonic impact of popular culture as a product of popular-cultural texts, sounds, and visual representations (mnemonic aesthetics), as well as the processes and agents involved in the production, distribution, and reception of these texts, sounds and representations (mnemonic strategies).]]></summary_en></project><project>
<id>15701</id><title_hr><![CDATA[Dolazna mobilnost viših asistenata - Ivor Lončarić]]></title_hr><title_en><![CDATA[]]></title_en><user_id>24947</user_id><user_firstLast_name>Ivor Lončarić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOL</proposal_type><proposal_call>2023-08</proposal_call><code>MOBDOL-2023-08-3537</code><acronim><![CDATA[]]></acronim><duration>09.02.2024 - 08.01.2026</duration><status>U tijeku</status><financ_value>83.375,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Mnogi industrijski procesi proizvode velike količine onečišćujućih tvari i stakleničkih plinova, poput ugljikovog dioksida. Uklanjanje tih plinova iz atmosfere, ili sprječavanje njihovog oslobađanja, jedan je od najvećih izazova našeg vremena. Cilj ovog projekta je pridonijeti razvoju novih metoda za uklanjanje stakleničkih plinova iz atmosfere ili smanjenju emisija iz industrijskih procesa. U tu svrhu u ovom projektu ćemo istražiti materijale poput nanoporoznog grafena za pretvaranje ugljikovog dioksida u bezopasne i korisne molekule koristeći svjetlost. Projekt će koristiti napredne kvantne izračune kako bi brže pretražio potencijalno korisne materijale prije eksperimentalne provjere. Uz računalno zahtjevne izračune iz prvih principa, koristit ćemo strojno učenje kako bismo efikasnije identificirali materijale najboljih svojstava odnosno smanjili broj računalno zahtjevnih kvantnih izračuna. Osim identifikacije materijala, naši atomistički izračuni pružit će fizikalno objašnjenje za najbitnije procese poput svjetlom induciranog prijenosa naboja koji omogućuje fotokatalitičke reakcije redukcije ugljikovog dioksida.Gostujući istraživač: dr. sc. Bernhard Kretz]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15702</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Daria Jardas Babić]]></title_hr><title_en><![CDATA[]]></title_en><user_id>865374</user_id><user_firstLast_name>Daria Jardas Babić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-9307</code><acronim><![CDATA[]]></acronim><duration>18.12.2023 - 14.06.2024</duration><status>U tijeku</status><financ_value>15.300,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Fakultet za fiziku]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Physics]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Istraživačka skupina u kojoj djeluje asistentica bavi se razvojem tankih filmova metalnih oksida sintetiziranih metodom atomske depozicije slojeva s naglaskom na njihova fotokatalitička svojstva. Grupa na Odsjeku za nanostrukturirane materijale Instituta Jožef Stefan, kod koje će se asistentica usavršavati, također se bavi istraživanjem fotokatalitičke aktivnosti metalnih oksida, no koriste se drugačijom metodom sinteze. Tijekom usavršavanja asistentica će se upoznati s različitim tehnikama karakterizacije materijala uključujući optičku spektroskopiju i elektronsku mikroskopiju. Konkretnije, cilj usavršavanja asistentice je obuka za pripremu uzoraka tankih filmova u presjeku za analizu pomoću transmisijskog elektronskog mikroskopa, korištenje UV-Vis spektrofotometra, obavljanje analiza atmosferskim pretražnim elektronskim mikroskopom te Raman spektrometrom. Tijekom usavršavanja na opremi Instituta, provodit će analize i mjerenja na svojim uzorcima koje će pripremiti prije odlaska na usavršavanje pomoću tehnike PEALD - plazmom potpomognute depozicije atomskih slojeva. Također, upoznati će i sol-gel metodu pripreme tankih filmova ZnO koju koriste u grupi-domaćinu.Organizacija-domaćin: Institut Jožef Stefan, Slovenija]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15703</id><title_hr><![CDATA[Dolazna mobilnost viših asistenata - Ante Prkić]]></title_hr><title_en><![CDATA[]]></title_en><user_id>13403</user_id><user_firstLast_name>Ante Prkić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOL</proposal_type><proposal_call>2023-08</proposal_call><code>MOBDOL-2023-08-5629</code><acronim><![CDATA[]]></acronim><duration>01.02.2024 - 30.06.2025</duration><status>U tijeku</status><financ_value>61.625,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Kemijsko-tehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Chemistry and Technology]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Predloženi projektni prijedlog promijenio bi dosadašnju praksu u području membranskih ion-selektivnih elektroda u čemu projektni tim ima veliko iskustvo (Radić, Komljenović 1991; Komljenović & Radić 1996; Radić, Komljenović & Dobčnik 2000; Kolar, Dobčnik & Radić 2001, Kolar & Dobčnik, 2003, Kolar i dr. 2010, Giljanović & Prkić 2010, Prkić, Giljanović & Bralić 2011, Paut et al. 2022). Tijekom realizacije projekta, na osnovu prethodnih znanstveno-istraživačkih rezultata, a uz pomoć ostatka konzorcija projekta NextGenMicrofluidics, pripremit ćemo sitotiskanu elektrodu (print-screen electrode - PSE) onih membrana koje su se već dokazale u našem ranijem radu tijekom realizacije projekta. Općenito, svi pripremljeni senzori bili bi uz dodatak nanočestica. Ovakvi senzori mogu se primijeniti za kontinuirano praćenje procesnih uvjeta proizvodnje, čime bi se smanjili troškovi proizvodnje. Iz svega navedenog može se zaključiti da bi predloženi projektni prijedlog doveo do jeftinijeg senzora i otvaranja novih radnih mjesta u visokoj tehnologiji.Gostujući istraživač: dr. sc. Ita Hajdin]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15707</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Boris Gomaz]]></title_hr><title_en><![CDATA[]]></title_en><user_id>863807</user_id><user_firstLast_name>Boris Gomaz</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-6223</code><acronim><![CDATA[]]></acronim><duration>20.10.2023 - 18.12.2023</duration><status>Završio</status><financ_value>5.100,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Za spoznaju kako proteini djeluju u živim organizmima glavni preduvjet je poznavanje njihovog oblika u prostoru jer je njihova struktura temelj njihove funkcije. Danas kao i proteklih desetljeća glavna metoda koja nam daje sliku trodimenzijske strukture proteina bila je i ostala metoda rendgenske kristalografije. Ona nam daje sliku kako proteini izgledaju do najsitnijih atomskih detalja. No iako je to najpreciznije što možemo doznati o samoj strukturi proteina, veliki je nedostatak to što nam kristalografija daje samo jednu sliku koja predstavlja samo jednu od mnoštva mogućih struktura koje jedan protein može imati. Naime, proteini se u živim organizmima stalno gibaju i neprestano mijenjaju svoj oblik, i to gibanje je podjednako važno za njihovu funkciju kao i sam oblik. To gibanje proteina ne možemo izravno opažati ali današnje mogućnosti naprednog računanja nam omogućavaju da s velikom vjernošću možemo simulirati kako se oni gibaju polazeći od slike koju imamo iz kristalografije, kroz tzv. molekulske simulacije. Kada jednom imamo i strukturu i načine gibanja proteina možemo puno više toga reći o tome kako taj protein radi. Ono što još možemo doznati je kako neka promjena na jednom dijelu proteina djeluje na neki udaljeni dio, a to je nešto što je prisutno kod velike većine proteina, i ta se pojava naziva alosterija. Lako je od ključne važnosti, još smo daleko od potpunog razumijevanja kako proteini postižu tu komunikaciju na daljinu.Jedan od načina kako možemo razumjeti alosteriju jest da pratimo kako se pojedini dijelovi proteina gibaju u skladu s drugima u vremenu. To znači da pratimo korelacije promjena u vremenu i iz toga zaključujemo da one promjene koje su bliske u vremenu moraju na neki način biti povezane u tzv. alosteričke puteve. No kako su proteini izuzetno kompleksne molekule s puno atoma, a simulacije proteina imaju i na milijune pojedinačnih koraka, potrebno je naći način kako iz tog mora nepovezanih gibanja naći ona koja su povezana.U sklopu projekta ALOKOMP razvijen je inovativni način praćenja gibanja proteina u vremenu preko dijagrama koji su u stanju prikazati velike brojeve međuovisnih točaka. No čak i ovako simplificiran prikaz gibanja u sebi nosi izazov pronalaska korelacija među tim dijagramima. U svojem boravku na Sveučilištu Brunel, asistent Boris Gomaz u suradnji s dr. Alessandrom Pandinijem radit će upravo na pronalasku efikasnog načina otkrivanja ovakvih korelacija. Dr. Pandini je autor programa i ekspert upravo u području pronalaska korelacija u gibanjima pojedinih dijelova proteina.Organizacija-domaćin: Brunel University, London, Ujedinjena Kraljevina]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15709</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Mia Radović]]></title_hr><title_en><![CDATA[]]></title_en><user_id>857311</user_id><user_firstLast_name>Mia Radović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-1110</code><acronim><![CDATA[]]></acronim><duration>06.11.2023 - 03.05.2024</duration><status>U tijeku</status><financ_value>15.300,00 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Biotehnologija, </scie_field_hr><scie_field_en>Biotechnology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Food Technology and Biotechnology]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Sukladno rastućim ekološkim, ekonomskim i tehnološkim zahtjevima, brojne industrije implementiraju načela biotehnologije i zelene kemije u svoje proizvodne procese. Pri tome su razvoj i implementacija biokatalizatora te novih, sigurnijih otapala esencijalni za njihov daljnji razvoj. U enzimskoj proizvodnji farmaceutski značajnih spojeva, posljednjih se godina intenzivno proučavaju nove generacije zelenih otapala medu kojima se ističu niskotemperaturna eutektična otapala. Njihov cilj je zamijeniti tradicionalna i štetna industrijska otapala uz uspostavljanje novih visokoučinkovitih i održivih procesa proizvodnje enantiomerno čistih spojeva. Ovo istraživanje se dotiče navedenih industrijskih zahtjeva. Točnije, cilj istraživanja je uspostaviti kontinuiran proces asimetrične redukcije acetofenona u enantiomerno čisti produkt u niskotemperaturnim eutektičkim otapalima primjenom mikroreaktorskih sustava. Navedena biokatalitička reakcija provest će se i optimirati šaržno i kontinuirano u mikroreaktorima s imobiliziranim biokatalizatorom. Kako bi se ispitala skalabilnost i primjenjivost razvijene reakcije u industriji, u sklopu usavršavanja procijenit će se ekonomska održivost i ekološka prihvatljivost navedenog procesa.Organizacija-domaćin: Fakulteta za kemijo in kemijsko tehnologijo Ljubljana, Slovenija]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15710</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Maja Jirouš]]></title_hr><title_en><![CDATA[]]></title_en><user_id>864821</user_id><user_firstLast_name>Maja Jirouš</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-1109</code><acronim><![CDATA[]]></acronim><duration>20.12.2023 - 20.03.2024</duration><status>U tijeku</status><financ_value>7.820,00 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Medicinski fakultet Osijek]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Medicine]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Vulgarna psorijaza je kronična, nezarazna upalna bolest kože koja pogađa milijune ljudi diljem svijeta. Unatoč neprestanim istraživačkim naporima, još uvijek postoje mnoge nepoznanice o uzrocima nastanka ove bolesti, što uvelike otežava razvoj specifičnih, dugoročno učinkovitih terapija. Znanstvena istraživanja ukazuju da su T limfociti, stanice imunološkog sustava koje prepoznaju strane antigene, jedni od glavnih pokretača upalnog procesa u psorijazi. Nedavna istraživanja sugeriraju da određeni tipovi tzv. „ne-klasičnih” T limfocita, poput ?? T i sluznici-pridruženih invarijantnih T (MAIT) limfocita, mogu imati ključnu ulogu u razvoju psorijaze.Jedan od pristupa u proučavanju uloge ovih limfocita u psorijazi je analiza repertoara T-staničnih receptora, molekula na površini T limfocita pomoću kojih prepoznaju strane antigene. Napredna metoda sekvenciranja RNA omogućuje uvid u genetsku informaciju koja kodira T-stanične receptore. Sekvenciranje RNA omogućuje otkrivanje specifičnih varijanti T-staničnih receptora te pruža uvid u način na koji se MAIT i ?? T limfociti aktiviraju i sudjeluju u upalnom procesu u psorijazi.U sklopu znanstveno-istraživačkog projekta na Medicinskom fakultetu u Osijeku (financiran od strane Hrvatske zaklade za znanost, UIP-2019-04-3494, voditeljica: izv. prof. Stana Tokić) provodi se analiza repertoara T-staničnih receptora (TCR) MAIT i ?? T limfocita oboljelih od psorijaze, s ciljem identifikacije njihove uloge u razvoju ove bolesti. Dosadašnja istraživanja usmjerena na analizu TCR-a u MAIT i ?? T limfocita izoliranih iz krvi pacijenata primjenom sekvenciranja RNA iz ukupne populacije stanica (bulk RNASeq) pokazala su vrijedne rezultate. S druge strane, istraživanje analize repertoara TCR-a u koži otežano je zbog nedovoljnog broja MAIT i ?? T limfocita koje je moguće izolirati iz uzoraka kože ograničene veličine. Štoviše, dosadašnja istraživanja HRZZ skupine ukazala su na izrazitu raznolikost MAIT i ?? T stanica, što iziskuje potrebu za korištenjem visoko-rezolucijskih metoda koje omogućuju klasifikaciju njihovih subpopulacija.Opisani istraživački izazovi predmet su znanstveno-stručnog usavršavanja, koje će se provesti primjenom naprednih analitičkih pristupa poput RNASeq analize pojedinačnih stanica (single-cell RNASeq) u kombinaciji sa spektralnom citometrijom, a u svrhu identifikacije specifičnosti pojedinačnih MAIT i ?? T stanica iz kože i krvi oboljelih od psorijaze. Pod vodstvom izv. prof. Martina Daveyja, čija su istraživanja oblikovala pionirske spoznaje u području MAIT i ?? T imunobiologije, doktorandica će imati jedinstvenu priliku steći iznimno važne vještine i znanja potrebna za daljnje proučavanje i razumijevanje uloga MAIT i ?? T limfocita u psorijazi. Primjena spektralne citometrije i single-cell RNASeq metode značajno će doprinijeti unaprjeđenju istrazivačkih kapaciteta doktorandice, i osigurati razvoj područja istraživanja trenutne grupe HRZZ istrazivača na Medicinskom fakultetu Osijek, kao i produbiti suradnju s Medicinskim fakultetom Warwick u Ujedinjenom Kraljevstvu.Sveukupno, rezultati istraživanja pružit će značajan uvid u karakteristike i aktivnost ?? T i MAIT limfocita u psorijazi, što može pomoći u boljem razumijevanju mehanizama koji uzrokuju upalni odgovor u psorijazi te otvoriti vrata za razvoj novih terapijskih pristupa. Znanstveno-stručno usavršavanje pruža jedinstvenu priliku za proširenje istraživačkih mogućnosti asistentice i istraživačke grupe u kojoj djeluje te osobni razvoj u perspektivnog i konkurentnog znanstvenika.Organizacija-domaćin: University of Warwick, Ujedinjena Kraljevina]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15711</id><title_hr><![CDATA[Odlazna mobilnost viših asistenata - Ivana Šimić]]></title_hr><title_en><![CDATA[]]></title_en><user_id>13064</user_id><user_firstLast_name>Ivana Šimić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBODL</proposal_type><proposal_call>2023-08</proposal_call><code>MOBODL-2023-08-9890</code><acronim><![CDATA[]]></acronim><duration>19.02.2024 - 18.03.2025</duration><status>U tijeku</status><financ_value>52.000,00 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Čovjek i životinje te okoliš koji dijele oduvijek su u bliskoj međusobnoj interakciji. Ta interakcija je s jedne strane pozitivna, međutim postoji i njezina druga, mračna strana koja se očituje kroz izmjenu patogena i pojavu bolesti. Novonastajuće zarazne bolesti su jedan od najvećih javnozdravstvenih izazova, a sam pojam obuhvaća one bolesti koje su po prvi put zahvatile ljudsku populaciju, ili su postojale i ranije, ali sada brzo raste broj novih slučajeva ili se šire na nova zemljopisna područja. Čak dvije trećine novonastajućih zaraznih bolesti koje pogađaju ljude su životinjskog podrijetla (zoonoze) i većina je uzrokovana virusima. Kako one mogu biti prijetnja čovječanstvu i koliko su moćne najbolje svjedoči nedavna pandemija COVID-19 koja je uzrokovala bolest u svih dobnih skupina, od djece do odraslih, i izazvala veliki broj smrtnih slučajeva diljem svijeta. Također, bilo je vidljivo koliko neznanje i neodgovarajuća pripremljenost doprinose strahu, širenju netočnih pa i opasnih informacija, ali i narušenom povjerenju u različite aktere povezene sa zaraznim bolestima. Pravodobne i znanstveno utemeljene protuepidemijske mjere su ključ uspješne borbe protiv zaraznih bolesti, a preduvjet za njihovo uspostavljanje je poznavanje uzročnika, njegova podrijetla i načina prijenosa, što sve proizlazi iz istraživanja. Upravo zato je važno da istraživači rade i kontinuirano se usavršavaju na problematici novonastajućih zaraznih bolesti te da se ta problematika približava kako stručnoj tako i široj javnosti. Kako zarazne bolesti ne poznaju granice, stvaranje međunarodne znanstvenoistraživačke mreže iznimno je važno za mlade istraživače radi stjecanja znanja, učenja suvremenih metoda i umrežavanje s drugim istraživačima.Organizacija-domaćin: Charles University, Faculty of Science, Češka Republika]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15712</id><title_hr><![CDATA[Odlazna mobilnost viših asistenata - Anja Rac Justament]]></title_hr><title_en><![CDATA[]]></title_en><user_id>22598</user_id><user_firstLast_name>Anja Rac Justament</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBODL</proposal_type><proposal_call>2023-08</proposal_call><code>MOBODL-2023-08-6116</code><acronim><![CDATA[]]></acronim><duration>01.02.2024 - 31.01.2025</duration><status>U tijeku</status><financ_value>48.000,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Koža je najveći ljudski organ koji štiti unutrašnja tkiva i organe. Njen višeslojni vanjski sloj, epiderma, građen je od gusto složenih stanica, keratinocita, koje komuniciraju sa svojom okolinom, odnosno susjednim stanicama i izvanstaničnim matriksom putem stvaranja adhezija. Proteini adhezija se zajednički se nazivaju adhesom, dok se proteini izvanstaničnog matriksa nazivaju matrisom. Genske mutacije koje pogađaju proteine adhezija, keratine 5 ili 14, uzrokuju bolest neožiljne ili epidermolitske epidermolize (engl. epidermolysis bullosa simplex, EBS) u kojoj stanice kože, keratinociti, postaju neotporne na fizički stres, što dovodi do stvaranja mjehura i rana na koži. Bolest je neizlječiva i pogađa oko 500.000 ljudi diljem svijeta, a liječenje je isključivo simptomatsko. Naime, iako bi genska terapija bila najbolji pristup liječenju bolesti, ona je za sada neizvediva jer je potrebno modulirati većinu stanica kože i drugih organa, što još više naglašava potrebu simptomatskih terapija. Predloženo istraživanje će sveobuhvatno istražiti adhesom i matrisom staničnog modela s karakterističnom mutacijom keratina koja uzrokuje EBS. Hipoteza projekta je da različiti omjeri mutiranog i divljeg tipa keratina dovode do promjene u sastavu adhesoma i matrisoma EBS keratinocita, zbog kojih dolazi do promjena u prijenosu signala, te stvaranja nakupina keratina, što izravno utječe na fenotip bolesti EBS. Rezultati istraživanja produbit će temeljno znanje o proteinima adhezija i proteinima izvanstaničnog matriksa i otkriti nove potencijalne mete za lokalizirane terapije koje pospješuju zacjeljivanje rana i smanjuju krhkost na mjestima koja su podložna ponavljanim traumama. Ovo usavršavanje bi moglo rezultirati otkrićem novih načina ublažavanja simptoma EBS. Nova znanja o adhezijama i proteinima izvanstaničnog matriksa potencijalno će potaknuti inovacije u industriji koje bi rezultirale novim pristupima u liječenju, poboljšanoj zdravstvenoj skrbi i u konačnici značajnom poboljšanju kvalitete života pacijenata. Sve navedeno bi u konačnici imalo direktan pozitivan utjecaj na gospodarstvo i društvo. Primjerice, ovakva usavršavanja stvaraju prilike za rad na naprednim tehnologijama i opremi, što djeluje pozitivno na istraživačku produktivnost istraživača, čime se otvaraju mogućnosti za ostvarivanje suradnji, dobivanje novih poslovnih ponuda, stipendija, te mogućnost prijave na razne natječaje za financiranje istraživačkih projekata.Organizacija-domaćin: Univerza v Ljubljani Medicinska fakulteta, Slovenija]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15713</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Mislav Majdak]]></title_hr><title_en><![CDATA[]]></title_en><user_id>864845</user_id><user_firstLast_name>Mislav Majdak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-7747</code><acronim><![CDATA[]]></acronim><duration>01.12.2023 - 28.05.2024</duration><status>U tijeku</status><financ_value>15.300,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Tekstilna tehnologija, </scie_field_hr><scie_field_en>Textile technology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Tekstilno-tehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Textile Technology]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Zahvaljujući svojoj sposobnosti oponašanja stanica ljudskog tijela, nano- i mikro-filamenti dobiveni primjenom elektroispredanja pripadaju novoj generaciji medicinskih tekstilnih materijala s bioaktivnim svojstvima. Štoviše, spomenuti filamenti obradom s aktivnim sredstvima mogu imati poboljšana antioksidativna, antiinflamatorna i antimikrobna svojstva. Stoga je cilj istraživanja koje će se provoditi u sklopu mobilnosti asistenta razviti nove medicinske tekstilne materijale koji će u svojoj strukturi sadržavati antimikrobne formulacije nanočestica metala, te antimikrobne formulacije nanočestica metala i polimernih mikrokapsula. Nadalje, provodit će se niz ispitivanja usmjerenih na karakterizaciju fizikalnih i bioloških svojstava novoizrađenih medicinskih materijala. U sklopu istraživanja očekuje se doprinos razvoju medicinskih tekstilnih materijala, ali i mogućih patenata. Ujedno, predloženo istraživanje će uvelike pridonijeti razvoju karijere asistenta kroz stjecanje novih iskustava.Organizacija-domaćin: University of Oxford, Ujedinjena Kraljevina]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15715</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Andro Rak]]></title_hr><title_en><![CDATA[]]></title_en><user_id>865186</user_id><user_firstLast_name>Andro Rak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-7678</code><acronim><![CDATA[]]></acronim><duration>01.12.2023 - 31.05.2024</duration><status>U tijeku</status><financ_value>15.555,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Temeljne tehničke znanosti, </scie_field_hr><scie_field_en>Basic engineering sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Tehnički fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Engineering]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Cilj znanstveno-istraživačkog usavršavanja je istražiti utjecaj valovitog vodećeg ruba krila uz samu podlogu gdje se generira, tzv. engl. ground effect. Istražit će se na koji način ovakva izvedba vodećeg ruba krila utječe na turbulentnu zonu iza aeroprofila te kakav će biti sveukupni efekt na silu otpora te posljedično i na utjecaj buke.Promotrit će se i dobitak potisne sile zbog približavanja krila podlozi gdje se stvara, tzv. suction effect na principu rasta brzine i pada tlaka na npr. području između podnice automobila i samog tla. Primjena ovakvog istraživanja je osim u spomenutoj autoindustriji, u motosportu te u avioindustriji kod slijetanja i uzlijetanja aviona zbog blizine podloge. Ovakvim istraživanjem očekuje se poboljšanje modela krila te smanjenje sile otpora. Pritom se smanjuje gubitak energije, a posljedično i količina utrošenog goriva te emisija CO2. Ovakav tip analize je trenutno vrlo aktualan zbog ciljanog smanjenja emisije CO2 i dekarbonizacije planeta, o čemu govori i Europski zeleni plan kojem je cilj postizanje klimatske neutralnosti do 2050. Za kraj, vrlo je važno staviti naglasak na korištenje superračunalnih resursa, od superračunala Bura u Rijeci, do mogućnosti korištenja IRIDIS-5 superračunala na Sveučilištu u Southamptonu. Također, doktorand će koristiti interni i suvremeni CANARD softver visoke rezolucije. Shodno svemu navedenom, smatramo kako će doktorandov napredak kroz ovu mobilnost biti neminovan te da će na temelju stečenih znanja doprinijeti povećanju ekspertize, znanja i ugleda Tehničkog fakulteta u Rijeci.Organizacija-domaćin: University of Southampton, Ujedinjena Kraljevina]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15717</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Lucija Šutić]]></title_hr><title_en><![CDATA[]]></title_en><user_id>865221</user_id><user_firstLast_name>Lucija Šutić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-4920</code><acronim><![CDATA[]]></acronim><duration>15.11.2022 - 15.12.2023</duration><status>U tijeku</status><financ_value>2.635,00 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Edukacijsko-rehabilitacijske znanosti, </scie_field_hr><scie_field_en>Physical education and rehabilitation sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Edukacijsko-rehabilitacijski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Education and Rehabilitation Sciences]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Asistentica Lucija Šutić u svom se doktorskom istraživanju bavi povezanošću prijateljskih odnosa, pozitivnog razvoja i mentalnog zdravlja u svakodnevnom životu adolescenata u Hrvatskoj. Takav pristup, još uvijek rijedak u hrvatskom kontekstu, omogućava joj da ne proučava samo razlike između adolescenata, već da promatra dnevne promjene unutar samog pojedinca. To čini pomoću mobilne aplikacije EARS koja sudionicima pet puta dnevno šalje pitanja o njihovim mislima, osjećajima i ponašanjima. Budući da su podaci za svakog sudionika prikupljeni u više mjerenja, zahtijevaju višerazinski pristup obradi podataka. Članovi Tilburg Experience Sampling Center i voditeljica centra, izv. prof. dr. sc. Eeske von Roekel, stručnjaci su za višerazinske obrade te bi usavršavanje kod izv. prof. dr. sc. von Roekel omogućilo asistentici Šutić da obradi podatke prikupljene u sklopu doktorskog istraživanja pomoću najsuvremenijih statističkih obrada. Tako obrađeni podaci omogućit će joj da bolje razumije ulogu prijateljskih odnosa i pozitivnog razvoja u zaštiti mentalnog zdravlja mladih te da na temelju dobivenih spoznaja predloži smjernice za prevenciju problema mentalnog zdravlja kod adolescenata u Hrvatskoj. Predloženo će joj usavršavanje također omogućiti da stekne dodatna znanja o ovom tipu istraživanja te da nastavi s njegovom primjenom i nakon obrane doktorata.Organizacija-domaćin: Tilburg University, Nizozemska]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15718</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Ana Lozančić]]></title_hr><title_en><![CDATA[]]></title_en><user_id>858406</user_id><user_firstLast_name>Ana Lozančić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-9240</code><acronim><![CDATA[]]></acronim><duration>17.02.2024 - 22.03.2024</duration><status>U tijeku</status><financ_value>2.975,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Potreba za novim materijalima koji posjeduju raznovrsnija i tehnički zahtjevnija svojstva kontinuirano se povećava. Jedan je od ciljeva dobiti materijale koji posjeduju ne samo jedno očekivano svojstvo (mehaničko, optičko, magnetsko, električno, ...) nego kombinaciju dvaju ili više njih. Plan našeg istraživanja je razviti i optimizirati metode priprave i stabilizacije oksalatnih kompleksa prijelaznih metala, koji bi pored magnetskog svojstava pokazivale i zanimljiva električna svojstva. Odabrani heterometalni oksalatni kompleksi služili bi kao prekursori za pripravu mješovitih metala oksida različite potencijalne primjene.Protonska vodljivost koordinacijskih spojeva i metaloorganskih mreža se intenzivno istražuje kao njihova nova funkcionalnost, zbog njihove kristalnosti, velike poroznosti, dizajna i prilagodljivosti strukture i svojstava. Najjednostavnija metoda za uvođenje nosača protona je uključivanje protuiona kao što su hidronijevi (H30+) ili amonijevi [NH4+, (CH3)2NH2+,...] kationi, tijekom sinteze, što rezultira pripravom spojeva građenih od nabijenih jedinki. Protuioni tvore vodikove veze s gostujućom vodom ili drugim komponentama spoja, stvarajući tako protonske vodljive putove.Homo- i heterometalni oksalatni kompleksi prijelaznih metala istraživani u sklopu doktorske disertacije Ane Lozančić priređeni su pristupom "kemije građevnih blokova"; vodene otopine anionskih oksalatnih građevnih blokova kroma(lll) i Zeljeza(ill), [III(C2O4)3]3-, koji sadrže dimetiletil odnosno dietilmetil amonijeve katione [(CH3)2(C2H5)NH+ i (CH3)2(C2H5)NH+], koriste se kao ligandi u reakcijama s jednostavnim solima prijelaznih metala, uz dodatak N-donorskih liganada po potrebi. Alkil-supstituirani amonijevi kationi se na ovaj način uvode u reakcije kao protonski nosači, te ugradnjom u strukture znatno utječu na njihovu vodljivost.Mjerenjem vodljivosti u ovisnosti o porastu relativne vlažnosti odnosno pri različitim temperaturama metodom impedancijske spektroskopije na Sveučilištu Paderbornu, u grupi Prof. dr. Michael Tiemann, odredit će se ne samo postojanje protonske vodljivosti u novopriređenim spojevima s alkil-amonijevim kationima i njihova osjetljivost na vlagu, nego će se i ustanoviti njezina točna vrijednost pri određenoj temperaturi i vlažnosti, kao i mehanizam postojećeg transporta protona. Za očekivati je da će istražena električna svojstva priređenih spojeva dovesti do njihove potencijalne primjene, prije svega kao neke vrste senzora.Organizacija-domaćin: Paderborn University, Njemačka]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15720</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Sara Krivačić]]></title_hr><title_en><![CDATA[]]></title_en><user_id>864918</user_id><user_firstLast_name>Sara Krivačić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-1638</code><acronim><![CDATA[]]></acronim><duration>01.11.2023 - 30.04.2024</duration><status>U tijeku</status><financ_value>15.470,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet kemijskog inženjerstva i tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Chemical Engineering and Technology]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[lonsko-selektivne elektrode bez unutarnjeg elektrolita omogućavaju veći doseg minijaturizacije te izvedbu senzora veće dostupnosti. Navedeni noviteti podrazumijevaju detekciju širokog spektra analita s uzbudljivim mogućnostima primjene, uključujući razvoj nosivih senzorskih konfiguracija te praćenje okolišnih čimbenika. Potencijal ekološki osviještene te ekonomski prihvatljive masovne proizvodnje novih senzorskih konfiguracija može se ostvariti implementacijom tehnologije inkjet ispisa, koja je unatoč svojim prednostima, u navedenu svrhu još uvijek nedovoljno istražena. Glavni cilj predloženog znanstveno-istraživačkog usavršavanja asistenta je procjena kompatibilnosti inkjet ispisanih fleksibilnih elektroda s najsuvremenijim ionsko-selektivnim senzorskim materijalima i mjernim tehnikama. Predloženo znanstveno-istraživačko usavršavanje provest će se u istraživačkoj skupini koja predvodi u razvoju ionskih senzora te će rezultirati razvojem jeftinih inkjet ispisanih fleksibilnih senzora poboljšanih analitičkih karakteristika. Ovakvo usavršavanje rezultirat će publikacijom rada visoke kvalitete i prezentacijom značajnih rezultata na važnim međunarodnim i domaćim konferencijama o kemijskim senzorima.Organizacija-domaćin: Université de Geneve, Švicarska]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15721</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Ana Milas]]></title_hr><title_en><![CDATA[]]></title_en><user_id>28644</user_id><user_firstLast_name>Ana Milas</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-3214</code><acronim><![CDATA[]]></acronim><duration>30.10.2023 - 29.11.2023</duration><status>U tijeku</status><financ_value>2.635,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Predloženo znanstveno-istraživačko usavršavanje temelji se na razvoju algoritma za autonomno istraživanje 3D prostora bespilotnom letjelicom. Cilj je proširiti postojeći algoritam tako da uzima u obzir informacije o objektima u prostoru s ciljem ubrzavanja istraživanja prostora i detaljnog pretraživanja objekata od interesa. U suradnji s Organizacijom-domaćin prethodno razvijeni algoritam za istraživanje prostora bi se doradio i testirao u simulacijskom okruženju koje bi pripremila Organizacija-domaćin. Osim simulacijskog dijela, Organizacija-domaćin osigurala bi opremu (bespilotne letjelice, senzore, upravljački sustav) te bi se algoritam testirao u stvarnom okruženju, u scenarijima opisanima u projektu BEEYONDERS. Algoritam služi za brzi pronalazak, identifikaciju ili modeliranje objekata od interesa u prostorima koji su nepoznati ili čiji je izgled narušen (primjerice zgrada nakon potresa, tunel nakon miniranja i sl.). Potreba za ovakvim rješenjima trenutno je jako visoka jer se korištenjem bespilotnih letjelica u opisanim scenarijima izbjegavaju moguće nesreće. Razmjenom ideja i znanja s Organizacijom-domaćin značajno bi se doprinijelo ubrzanju razvijanja rješenja i potpunosti razvijenih algoritama istraživanja prostora. Detaljno testiranje algoritma u izazovnim okruženjima rezultiralo bi i znanstvenim člankom i potencijalnom daljnjom suradnjom s Organizacijom-domaćin. Uz to, rezultati bi bili korisni i članovima grupe unutar Organizacije jer bi se mogli koristiti djelomično za trenutne projekte i natjecanje na kojima grupa sudjeluje.Organizacija-domaćin: Advanced Center for Aerospace Technologies, Španjolska]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15722</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Iva Dominović Novković]]></title_hr><title_en><![CDATA[]]></title_en><user_id>865334</user_id><user_firstLast_name>Iva Dominović Novković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-6353</code><acronim><![CDATA[]]></acronim><duration>15.11.2023 - 14.02.2024</duration><status>U tijeku</status><financ_value>7.820,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Interdisciplinarne prirodne znanosti, </scie_field_hr><scie_field_en>Interdisciplinary natural sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Općeprisutne klimatske promjene imaju značajan utjecaj i na morska područja i oceane, pri čemu je smanjenje topljivosti kisika jedna od konsekvenci koja može imati značajne posljedice na živi svijet. Obalna područja nisu izuzetak, a jedno od takvih područja koja već dugo vremena privlače interes znanstvenika je i rogozničko jezero Zmajevo oko, koje je specifično po svojoj vertikalnoj raslojenosti i povremenim izmješavanjima cijelog vodenog stupca koje dovodi do potpunog pomora biljnog i životinjskog svijeta. Istraživanja Zmajevog oka su do sada obavljana putem mjerenja fizičkih i biogeokemijskih svojstava u jezeru, no u okviru ove specijalizacije bi se potpuna dinamika modela pokušala reproducirati i korištenjem hidrodinamičkih modela. Takav model bi se razvio u suradnji sa Sveučilištem Bangor (Wales, UK), koji posjeduju vještine potrebne za razvoj modela. Očekivani rezultati bi trebali dati odgovore na pitanja koji su razlozi opaženih izmješavanja vodenog stupca, zašto su takvi događaji učestaliji posljednjih godina, te koliko često će se takvi događaji odvijati u budućoj klimi. Odgovori na ova pitanja omogućili bi bolje upravljanje samim jezerom, kao i drugim obalnim područjima koja zbog klimatskih promjena imaju deficit otopljenog kisika, na primjer Vransko jezero, ali i mnoga druga područja u Republici Hrvatskoj i u obalnim morima svijeta.Organizacija-domaćin: Bangor University, Ujedinjena Kraljevina]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15723</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Ana Bekavac]]></title_hr><title_en><![CDATA[]]></title_en><user_id>858430</user_id><user_firstLast_name>Ana Bekavac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-5138</code><acronim><![CDATA[]]></acronim><duration>01.02.2024 - 17.05.2024</duration><status>U tijeku</status><financ_value>9.095,00 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Neurodegenerativne bolesti poput amiotrofične lateralne skleroze i Alzheimerove bolesti su vrlo teške, progresivne i trenutno neizlječive bolesti. Zajednička im je prisutnost smrti neurona, poremećaji funkcije sinapsi, patološka nakupljanja pogrešno smotanih proteina, promjene citoskeleta, narušen metabolizam te poremećaji strukture DNA i RNA. Istraživačka grupa u kojoj radi doktorandica Bekavac je posvećena istraživanju patofizioloških mehanizama koji dovode do demencije, dok grupa prof. Lewandowskog istražuje takva zbivanja tijekom nastanka amiotrofične lateralne skleroze. Budući da doktorandica Bekavac radi na modelu ljudskih organoida koji sadrže dodatnu kopiju SOD1 gena, a koji je jedan od najvažnijih gena u patogenezi ALS-a, postoji jak obostran interes za suradnju Medicinskog fakulteta u Zagrebu te Karolinska Instituta. Doktorandica Bekavac će tijekom boravka u Švedskoj sa svojim domaćinima razviti specijalni računalni algoritam kojim će moći analizirati nakupljanje pogrešno smotanih proteina koji su karakteristični za ove bolesti. Na ovaj način ćemo značajno zajednički pridonijeti razumijevanju patogeneze Alzheimerove demencije te amiotrofične lateralne skleroze te će tako ovaj projekt biti primjer ubrzanog napretka u biomedicini temeljenog na kumulativnom učinku interdisciplinarne međunarodne suradnje.Organizacija-domaćin: Karolinska Institute, Švedska]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15724</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Leon Halić]]></title_hr><title_en><![CDATA[]]></title_en><user_id>867190</user_id><user_firstLast_name>Leon Halić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-7349</code><acronim><![CDATA[]]></acronim><duration>22.01.2024 - 15.03.2024</duration><status>U tijeku</status><financ_value>4.590,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Neutrini su trenutno najmisterioznija fundamentalna čestica za koju znamo da postoji, ponajviše zbog toga što rijetko interagira s okolnom materijom. što nam otežava proučavanje prirode te čestice. Detektori neutrina često su samo jako veliki spremnici vode, tekućeg argona ili drugih tvari kako bi što vise povećali šansu da neutrino interagira s tom tvari. U pripremi takvih eksperimenata nužno je znati kako različite specifikacije detektora utječu na njegove performanse i mogućnosti. U tu svrhu, prije same izgradnje, rade se softverske simulacije samih detektora: od simulacije neutrinskih interakcija unutar detektora, preko odaziva samog detektora, do neželjene pozadine koja je sveprisutna. Za izradu takvih simulacija, postoje specijalizirani programski paketi, no često ti programi nisu dovoljno specifični te se za svaki eksperiment moraju dodatno modificirati. Stručnjaka za izradu takvih simulacija ima jako malo, što otežava edukaciju doktoranada u tom području. Ovo usavršavanje je osmišljeno upravo u svrhu dodatne edukacije za izradu detektorskih simulacija. Istraživačka grupa koja je domaćin ovom usavršavanju, predvođena dr. sc. Anselmom Meregagliom, ima iskustva u izradi detektorskih simulacija i u izradi vodećeg programa (GENIE [5]) koji se koristi za simuliranje interakcija neutrina. Znanje koje će se dobiti uvelike će pomoći u provođenju doktorskog istraživanja i u daljnjoj karijeri.Organizacija-domaćin: Université de Bordeaux, Francuska]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15726</id><title_hr><![CDATA[Odlazna mobilnost viših asistenata - Stjepan Frljić]]></title_hr><title_en><![CDATA[]]></title_en><user_id>24102</user_id><user_firstLast_name>Stjepan Frljić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBODL</proposal_type><proposal_call>2023-08</proposal_call><code>MOBODL-2023-08-1801</code><acronim><![CDATA[]]></acronim><duration>11.03.2024 - 10.03.2025</duration><status>U tijeku</status><financ_value>48.000,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Uspjeh na tržištu tehnologije zahtijeva konkurentnu cijenu, ali i iznimnu kvalitetu proizvoda. U optimizaciji tvorničkih tehnoloških proizvoda dominantnu ulogu ima računalno modeliranje temelieno na metodi konačnih elemenata jer nudi visoko pouzdanu i ekonomičnu alternativu skupom procesu izrade i testiranja fizičkih prototipa proizvoda. Tvrtka Končar — Mjerni transformatori izrađuje naponske transformatore velike snage koji predstavljaju originalni hrvatski koncept energetsko-distributivnih transformatora s lameliranom feromagnetskom jezgrom koja je specifičnoga, otvorenoga tipa. Kako bi se omogućio njihov dodatni uspjeh na tržištu, nužna je optimizacija dizajna lamelirane feromagnetske jezgre otvorenoga tipa. Međutim, izravna primjena računalnog modeliranja temeljenog na metodi konačnih elemenata na lameliranu feromagnetsku jezgru praktično nije moguća zbog vrlo izražene heterogenosti materijala unutar jezgre. Naime, lamelirana jezgra se izrađuje slaganjem velikog broja iznimno tankih lamela međusobno izoliranih ekstremno tankim slojevima električne izolacije pa bi izravna primjena metode konačnih elemenata zahtijevala prevelike računalne resurse, a sama simulacija bi unatoč tome trajala tjednima. Prema tome, nužan je razvoj novih matematičkih formulacija kojima bi se nekoliko desetaka puta smanjili zahtjevi na računalne resurse i trajanje simulacije uz visoku točnost rezultata izračuna. Mladi istraživač bi se na svom znanstveno-istraživačkom usavršavanju upravo bavio razvojem takvih matematičkih formulacija baziranih na metodi konačnih elemenata. Pritom bi matematička formulacija morala biti posebno skrojena za računalno modeliranje feromagnetskih jezgri koje su jedinstvenoga, otvorenoga tipa.Na svom doktorskom studiju, mladi istraživač je po prvi put izračunao kako na gubitke zbog vrtložnih struja otpada najviše 50% ukupnih gubitaka. Dakle, postoji jasna potreba za razvojem matematičke formulacije koja bi omogućila izračun sveukupnih gubitaka u feromagnetskoj jezgri, a koji su zbroj gubitaka zbog vrtložnih struja, gubitaka zbog histereze te anomalijskih gubitaka. Odlaskom na usavršavanje, mladi istraživač bi se bavio razvojem algoritma za korištenje u računalnom modeliranju i optimizaciji feromagnetske jezgre jedinstvenoga, otvorenoga tipa kakvu proizvodi tvrtka Končar — Mjerni transformatori.Organizacija-domaćin: Vienna University of Technology, Austrija]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15727</id><title_hr><![CDATA[Odlazna mobilnost viših asistenata - Bojana Mikelenić]]></title_hr><title_en><![CDATA[]]></title_en><user_id>867304</user_id><user_firstLast_name>Bojana Mikelenić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBODL</proposal_type><proposal_call>2023-08</proposal_call><code>MOBODL-2023-08-9511</code><acronim><![CDATA[]]></acronim><duration>01.03.2024 - 28.02.2025</duration><status>U tijeku</status><financ_value>48.000,00 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filologija, </scie_field_hr><scie_field_en>Philology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Znanstveno-istraživačko usavršavanje u trajanju od godine dana zamišljeno je tako da se u svakom tromjesečnom razdoblju u središte postavlja jedna tema. Sve su teme međusobno povezane i neke se provedene aktivnosti u sklopu jedne od njih nastavljaju ili nadopunjuju tijekom drugih. Prva se tema tiče usporednih korpusa, velikih jezičnih baza koje sadrže originalne tekstove na jednom jeziku i prijevod na jedan ili vise drugih jezika. Konkretno, radit će se na proširenju postojećeg korpusa romanskih jezika i hrvatskog RomCro (Bikić-Carić, Mikelenić i Bezlaj, 2023). Na tom će se proširenom korpusu provoditi aktivnosti vezane uz ostale teme. Druga je tema vezana uz jezični alat za pretragu usporednih korpusa ReSiPC (Oliver i Mikelenić, 2020), kojem se namjerava poboljšati funkcionalnost, kako bi bio jednostavniji za uporabu te kako bi mogao služiti za pronalazak još složenijih jezičnih pojava. U tu svrhu provest će se i jedno specifično istraživanje koristeći taj alat na usporednom korpusu u kojem će se jezični elementi istoga oblika u španjolskom pokušati razlikovati uz pomoć hrvatskoga. Treća i četvrta tema vezane su uz primjenu usporednih korpusa u strojnom prevođenju i u poučavanju jezika. Strojno ili automatsko prevođenje danas ima sve širu uporabu, od automatskih prevoditelja (npr. Google Translate), do alata koji pomažu prevoditeljima u radu, poput prijevodnih memorija. S obzirom na to da je RomCro korpus književnih tekstova, u sklopu treće teme ispitat će se njegova korisnost za književno strojno prevođenje romanskih jezika i hrvatskog. Naposljetku, četvrta je tema vezana uz izradu dvojezičnih (španjolski-hrvatski) elektroničkih knjiga pomoću alata strojnog prevođenja te uporabu tih knjiga za izradu materijala za nastavu na studiju španjolskog jezika i književnosti na Filozofskom fakultetu u Zagrebu. Svako tromjesečno razdoblje završit će radionicom koju će predloženica uz pomoć mentora organizirati za istraživače mentorove istraživačke skupine. Također, predviđeno je da rezultati svake od četiriju tema budu predstavljeni kao znanstveni članak, predavanje na konferenciji ili predavanje na seminaru u organizaciji institucije-domaćina. Uz istraživački rad, predloženica će sudjelovati u nastavi dvaju kolegija na instituciji-domaćinu, čime će steći vrijedno znanje i iskustvo, koje će potom moći primijeniti u vlastitom nastavnom radu.Organizacija-domaćin: Universitat Oberta de Catalunya, Španjolska]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15729</id><title_hr><![CDATA[Dolazna mobilnost viših asistenata - Marko Černe]]></title_hr><title_en><![CDATA[]]></title_en><user_id>20413</user_id><user_firstLast_name>Marko Černe</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOL</proposal_type><proposal_call>2023-08</proposal_call><code>MOBDOL-2023-08-5800</code><acronim><![CDATA[]]></acronim><duration>31.03.2024 - 30.03.2026</duration><status>U tijeku</status><financ_value>87.000,00 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Institut za poljoprivredu i turizam]]></institution_hr><institution_en><![CDATA[Institute of Agriculture and Tourism in Poreč]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[U području Mediterana, uključujući i RH, značajan broj poljoprivrednih tvrtki, u prvom redu uljara, odlaže velike količine neobrađene komine maslina u okoliš, bez da se taj materijal kvalitetno valorizira. Što je još negativnije, tako odložena komina maslina, zbog sadržaja fenolnih spojeva, ostataka neekstrahiranog ulja i organskih kiselina, postaje potencijalni izvor zagađenja tla i podzemnih voda. Jedan od najvećih problema kod komine maslina je vezan uz sporu biorazgradnju, što je posljedica niskog udjela N, većeg sadržaja fitotoksičnih i antimikrobnih spojeva, kiselog pH, prisutnosti rekalcitrantnih tvari te specifičnih fizikalnih karakteristika (smanjena poroznost). Ispitivanje fitotoksičnosti glavni je zahtjev sigurnog korištenja komposta u tlu, njegovog stupnja stabilnosti ili zrelosti. Uzimajući u obzir važnost kompostiranja za buduće upravljanje ostacima iz prerade maslina, kao i za održivu poljoprivrednu proizvodnju, gostujući istraživač fokusirat će se na dinamiku kompostiranja komine maslina u bioreaktorima, kao i parametre fitotoksičnosti pomoću bioloških testova i kemijskih analiza. U sklopu predloženog projekta razmotrit će se utjecaj različitih izvora N (UREA, ovčji gnoj) kao dodatka kompostnim smjesama na proces kompostiranja i prikladnost finalnog supstrata u poljoprivredne svrhe. U okviru eksperimentalnog dizajna dva će se različita tretmana i kontrole razmatrati u dvofaktorskom pokusu. Nadalje, temperatura, relativna vlaga i proizvodnja CO2 pratit će se kontinuirano tijekom procesa kompostiranja. Zrelost komposta procjenjivat će se prema omjeru C/N, omjeru između NO3-N i NH4-N, stopi stvaranja CO2, te biotestovima, dok će se njegova kvaliteta odrediti na temelju pH, EC, organske tvari, sadržaja hraniva, koncentracije metala u tragovima te udjela vlage i pepela. Gostujući istraživač će svojim sudjelovanjem na projektu dati značajan napredak održivom korištenju komine masline, doprinos o mogućnostima primjene komine masline kao gnojiva u ekološkoj poljoprivredi, potencijalnom poboljšanju regulacije upravljanja kominom na temelju dobivenih podataka i doprinos ublažavanju utjecaja na okoliš.Gostujući istraživač: dr. sc. Mohammed Bouhadi]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15732</id><title_hr><![CDATA[Odlazna mobilnost viših asistenata - Vlatko Gašparić]]></title_hr><title_en><![CDATA[]]></title_en><user_id>25454</user_id><user_firstLast_name>Vlatko Gašparić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBODL</proposal_type><proposal_call>2023-08</proposal_call><code>MOBODL-2023-08-2860</code><acronim><![CDATA[]]></acronim><duration>01.03.2024 - 28.02.2025</duration><status>U tijeku</status><financ_value>48.000,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Ramanova spektroskopija nezaobilazna je metoda za identifikaciju i karakterizaciju tvari koja se koristi u velikom broju znanstvenih i industrijskih područja. Metoda koristi Ramanovo raspršenje koje se javlja prilikom obasjavanja tvari svjetlošću (najčešće laserom). Zbog toga što je pojava Ramanovog raspršenja vrio malog udjela u ukupnom raspršenju, signal koji se dobiva je vrlo slab. Iz tog razloga razvijen je cijeli niz metoda za pojačanje. Vrlo popularna i moćna metoda pojačanja temelji se na plazmonima, koji su kolektivne oscilacije elektrona u metalu prilikom obasjavanja svjetlošću. No u zadnje vrijeme, jedna od najperspektivnijih novih metoda pojačanja temelji se na fotonskom nanomlazu. Fotonski nanomlaz je izrazito intenzivan i uzak snop svjetlosti koji se javlja u određenim uvjetima prilikom obasjavanja mikroleće svjetlošću.Ovo usavršavanje bavi se razvojem metode pojačanja Ramanove spektroskopije pomoću fotonskog nanomlaza, kombiniranog pojačanja fotonskim nanomlazom i plazmonima, te razvojem inovativne optičke naprave za kombinirano pojačanje.Usavršavanje donosi višestruke značajne pozitivne znanstvene, društvene i gospodarske učinke. Poboljšanjem metode pojačanja Ramanove spektroskopije fotonskim nanomlazom pozicionira se metoda i nudi kao vrijedna opcija pojačanja između ostalih metoda, te se unaprjeđuje znanje i o samom fotonskom nanomlazu, što će pomoći razvoju i ostalih područja u kojima se on koristi, kao što su super rezolucija, nanolitografija, pojačanje luminiscencije, optička pinceta, solarne ćelije itd. Razvojem kombiniranog pojačanja istražuje se područje koje je tek otvoreno u dosadašnjoj literaturi, a ima potencijal biti uz bok najpopularnijim metodama pojačanja. Također, istraživanjem inovativnog rješenja za kombinirano pojačanje s kontroliranom nanostrukturom otvara se sasvim nova opcija pojačanja, koja bi u budućnosti mogla biti od revolucionarne važnosti za Ramanovu spektroskopiju. U konačnici, razvojem pojačanja Ramanove spektroskopije razvija se ne samo to područje nego i sve primjene i područja u kojima se Ramanova spektroskopija koristi, primjerice za određivanje energijskih nivoa molekula, detektiranje plinova onečišćivača, proučavanje strukturnih promjena u materijalima, kemijsku i biološku karakterizaciju, proučavanje DNK i fonona u proteinima, karakterizaciju umjetnina i slično, što ima značajne učinke ne samo na znanost nego i na gospodarsku djelatnost, industriju i društvo.Usavršavanje također ima značajan utjecaj na karijeru mladog istraživača, ne samo za znanstveni napredak i napredovanje i usmjeravanje u području kojim se bavi, nego i za osobni razvoj, usvajanje novih vještina, razmjenu iskustava i znanja, komunikacijske vještine te za neprocjenjivo iskustvo rada u međunarodnom okruženju s vrhunskim stručnjacima u području.Organizacija-domaćin: Wigner Research Centre for Physics, Mađarska]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15733</id><title_hr><![CDATA[Dolazna mobilnost viših asistenata - Zrinka Božić Blanuša]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5581</user_id><user_firstLast_name>Zrinka Božić Blanuša</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOL</proposal_type><proposal_call>2023-08</proposal_call><code>MOBDOL-2023-08-7243</code><acronim><![CDATA[]]></acronim><duration>31.03.2024 - 30.03.2026</duration><status>U tijeku</status><financ_value>87.000,00 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filologija, </scie_field_hr><scie_field_en>Philology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Projekt The Cartography of the Political Novel in Europe usmjeren je na istraživanje europskog političkog romana zbog čega projektni tim okuplja istraživače čija ekspertiza pokriva dobar dio europskih i neeuropskih književnosti. Da bi se što šire zahvatilo nasljeđe europskog političkog romana, u sklopu projekta će se uspostaviti i mreža eksperata koji obuhvaćaju države i književnosti koje sam konzorcij ne pokriva svojom ekspertizom. U tom smislu je sudjelovanje nekoga kao što je Eric Bergman sa svojom komparatističkom perspektivom, izvrsnim poznavanjem nordijske književne tradicije (naročito finske književnosti), američke književnosti (naročito Chicano tradicije) u projektnom timu od iznimne važnosti. Istraživački tim Filozofskog fakulteta okuplja romaniste, komparatiste, kroatiste, angliste, povjesničare, redovite profesore u trajnom zvanju, izvanredne profesore, docente, vise asistente najrazličitijih istraživačkih interesa (književna teorija, književna povijest, sociologija književnosti, kulturalni studiji i sl.) koji će se u sklopu ovoga projekta baviti kompleksnim pitanjima političkog romana kao književnog žanra, ali i važnog medija za političko obrazovanje. Upravo će Bergman sa svojim radom na jednom specifičnom književnom fenomenu (nepantla) koji se oblikuje između različitih kultura, doprinijeti raznolikosti perspektiva, metodologija i uvida hrvatskog dijela tima, ali i cijelog konzorcija. Pritom će posebno dragocjen biti njegov pogled „izvana“ na heterogen i iznimno kompleksan korpus post-jugoslavenske književnosti i to naročito one koja nastaje u drugim kulturnim kontekstima i na drugim jezicima (a o kojoj se i kod nas malo zna).Gostujući istraživač: dr. sc. Eric Petter Sakari Bergman]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15734</id><title_hr><![CDATA[Odlazna mobilnost viših asistenata - Kristijan Kilassa Kvaternik]]></title_hr><title_en><![CDATA[]]></title_en><user_id>20035</user_id><user_firstLast_name>Kristijan Kilassa Kvaternik</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBODL</proposal_type><proposal_call>2023-08</proposal_call><code>MOBODL-2023-08-4960</code><acronim><![CDATA[]]></acronim><duration>25.03.2024 - 24.03.2026</duration><status>U tijeku</status><financ_value>96.000,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[U ovom se istraživanju bavimo Lozijevim i Hénonovim preslikavanjima, dvoparametarskim familijama preslikavanja ravnine koje posjeduju kaotična svojstva. Na određenim parametarskim skupovima želimo istražiti je li dinamika tih preslikavanja jedinstveno određena parametarskim parom, točnije, mijenjaju li se uvijek neka dinamička svojstva s promjenom parametara. Ovo će usavršavanje napraviti iskorak u razumijevanju važnih modela kaotičnih dinamičkih sustava, a unaprijedit će karijeru istraživača, dati mu nova znanja i vještine važne za znanstveni rad te mu omogućiti suradnju s kolegama sličnih interesa na Jagielonskom sveučilištu u Krakovu, Poljska.Organizacija-domaćin: Jagiellonian University, Institute of Mathematics, Poljska]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15735</id><title_hr><![CDATA[Odlazna mobilnost viših asistenata - Josip Žubrinić]]></title_hr><title_en><![CDATA[]]></title_en><user_id>23191</user_id><user_firstLast_name>Josip Žubrinić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBODL</proposal_type><proposal_call>2023-08</proposal_call><code>MOBODL-2023-08-4177</code><acronim><![CDATA[]]></acronim><duration>01.03.2024 - 28.02.2025</duration><status>U tijeku</status><financ_value>48.000,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Znanstveno usavršavanje Josipa Žubrinića na Sveučilištu u Dortmundu pod vodstvom prof. dr. sc. Petera Belle sastoji se od znanstvenog istraživanja u području znanosti materijala i primijenjene matematičke analize. Precizna tema istraživanja je analiza modela legura s pamćenjem oblika (LPO), točnije pojave njihove fazne tranzicije pri promjeni stresa ili temperature. Poznato je da se u takvim materijalima javlja mikrostruktura faza pod nazivom austenit i martenzit te da su im materijalna svojstva određena periodičkim uzorcima u mikrostrukturi. Priroda pokušava minimizirati energiju takvog fizikalnog sustava, prisiljavajući time formiranje uzoraka u materijalu. Matematički model te pojave opisuje se minimizacijom nekonveksnog energetskog funkcionala te primjenom matematičkih alata varijacijskog računa otkrivaju se globalni minimizatori i njihova svojstva. Usavršavanje uključuje upoznavanje s modernim tehnikama varijacijskog računa, geometrijske teorije mjere i primjena tih znanja u otkrivanju mikrostrukture u LPO. Utjecaj ovog istraživanja je u boljem razumijevanju ovakvih materijala, što dodatno omogućuje napredak u tehnologiji, medicini i industriji. Primjerice, LPO se koriste u medicini u proizvodnji vaskularnih implantanata, ortodontskih uređaja te nalaze primjenu u automobilskoj industriji, elektronici, robotici i mnogim drugim industrijama gdje se zahtjeva precizno kontroliranje oblika i pokreta materijala. Osim toga, usavršavanje ima i velik utjecaj na karijeru mladog istraživača s obzirom da će steći znanja iz nove teme vezane uz relevantne fizikalne modele, naučiti modernu matematičku teoriju i uspostaviti znanstvenu suradnju s aktivnom znanstvenom grupom.Organizacija-domaćin: TU Dortmund, Fakultät für Mathematik, Njemačka]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15737</id><title_hr><![CDATA[Odlazna mobilnost viših asistenata - Jelena Železnjak]]></title_hr><title_en><![CDATA[]]></title_en><user_id>17754</user_id><user_firstLast_name>Jelena Železnjak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBODL</proposal_type><proposal_call>2023-08</proposal_call><code>MOBODL-2023-08-7147</code><acronim><![CDATA[]]></acronim><duration>01.03.2024 - 30.06.2025</duration><status>U tijeku</status><financ_value>64.000,00 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Medicine]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Imunološki sustav je naš prirodni &#39;branitelj&#39; koji štiti tijelo od bolesti. Da bi dobro funkcionirao, mora održavati ravnotežu kako bi se uklonile prijetnje, poput virusa i tumora, bez izazivanja bolesti u tijelu. Ponekad se ta ravnoteža može poremetiti, što može dovesti do razvoja tumora, autoimunih bolesti ili gubitka kontrole nad infekcijom. Bitnu ulogu u održavanju te ravnoteže ima i receptor IL-1R8, čija je uloga smanjivanje upalnih procesa te utišavanje prejake aktivacije stanica imunološkog sustava. To je posebno važno kod prirodnih stanica ubojica (stanica NK), na čijoj je površini IL-1R8 najviše izražen, i koje mogu prepoznati stresom- i tumorski-promijenjene stanice te ih uništiti. Navedenu činjenicu su iskoristili neki virusi i tumori tako što su zadržali IL-1R8 na površini promijenjenih stanica i na taj način utišali odgovor imunoloških stanica. Stoga je prvi cilj usavršavanja mlade istraživačice vidjeti kako sezonski virusi poput gripe, RSV-a i SARS-CoV-2 utječu na aktivaciju stanica NK i razrješenje infekcije preko receptora IL-1R8 te mogu li se ta saznanja primijeniti u liječenju virusnih bolesti.Osim u obrani od virusnih infekcija, stanice NK sprečavaju i nastanak tumora. Metodama genetičkog inženjerstva ove se stanice mogu usmjeriti isključivo na ubijanje tumorskih stanica. Takve modificirane stanice zovu se CAR stanice odnosno, stanice s kimeričnim antigenskim receptorom. I za CAR stanice izuzetno je važna regulacija njihove aktivnosti kako ne bi napadale pacijenta, nego samo njegov tumor. IL-1R8 i tu može igrati važnu ulogu, čije je ispitivanje drugi cilj mlade istraživačice.Organizacija-domaćin: Humanitas Research Hospital, Milano, Italija]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15738</id><title_hr><![CDATA[Odlazna mobilnost viših asistenata - Goran Poje]]></title_hr><title_en><![CDATA[]]></title_en><user_id>25308</user_id><user_firstLast_name>Goran Poje</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBODL</proposal_type><proposal_call>2023-08</proposal_call><code>MOBODL-2023-08-3031</code><acronim><![CDATA[]]></acronim><duration>29.03.2024 - 28.03.2025</duration><status>U tijeku</status><financ_value>48.000,00 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Farmacija, </scie_field_hr><scie_field_en>Pharmaceutical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Farmaceutsko-biokemijski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Pharmacy and Biochemistry]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Rak je druga najsmrtonosnija bolest na svijetu od koje godišnje umre oko 10 milijuna ljudi zbog čega predstavlja globalni javnozdravstveni problem. Liječenje raka je izazovno jer postojeća terapija gubi učinkovitost uslijed pojave rezistencije, što dovodi do recidiva i progresije bolesti. Pored toga, lijekovi često ispoljavaju neželjena djelovanja zbog čega je potrebno kontinuirano istraživati i razvijati nove, učinkovitije i sigurnije djelatne tvari. U okviru ovog istraživanja dizajnirat će se i pripraviti nova, do sada neopisana, klasa spojeva - hibridne molekule harmina i kurkumina pirazolinskog tipa. Očekuje se da će kovalentno povezivanje harmina i kurkumina, prirodnih produkata s izraženim protutumorskim svojstvima, rezultirati hibridnim molekulama snažnijeg protutumorskog djelovanja koje će biti otpornije prema razvoju rezistencije. Uvođenje pirazolina u strukturu hibrida trebalo bi poboljšati fizičko-kemijska svojstva molekula i dodatno pojačati protutumorsko djelovanje. Novosintetiziranim hibridima ispitat će se antiproliferativno djelovanje in vitro na humanim tumorskim staničnim linijama i jednoj netumorskoj liniji kako bi se odredila selektivnost djelovanja. Analizom dobivenih rezultata utvrdit će se dijelovi strukture bitni za djelovanje i identificirati vodeći spoj za daljnja istraživanja. Predloženo istraživanje je multidisciplinarno i od velikog značaja jer će: 1) istražiti novi pristup u dizajniranju i razvoju ljekovitih tvari, 2) obogatiti područje farmaceutske kemije novim hibridnim molekulama i spoznajama o njihovom biološkom djelovanju, 3) omogućiti razvoj novih metodologija za pripravu hibridnih molekula i 4) potaknuti i/ili usmjeriti istraživanja drugih istraživačkih skupina, što će u konačnici doprinijeti razvoju novih terapijskih mogućnosti za liječenje raka i imati pozitivne socioekonomske učinke. Osim toga, omogućit će istraživaču stjecanje novih znanja, poznanstava i vještina, što će pozitivno utjecati na njegov daljnji karijerni razvoj.Organizacija-domaćin: Faculty of Bioscience Engineering Gent, Belgija]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15739</id><title_hr><![CDATA[Odlazna mobilnost viših asistenata - Linda Bjedov]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4036</user_id><user_firstLast_name>Linda Bjedov</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBODL</proposal_type><proposal_call>2023-08</proposal_call><code>MOBODL-2023-08-1329</code><acronim><![CDATA[]]></acronim><duration>01.03.2024 - 28.02.2025</duration><status>U tijeku</status><financ_value>48.000,00 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Šumarstvo, </scie_field_hr><scie_field_en>Forestry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet šumarstva i drvne tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Forestry and Wood Technology]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Epidemije i pandemije, većina njih uzrokovana zoonotskim i vektorskim bolestima, globalno prijete našem zdravlju i dobrobiti. Prevencija budućih izbijanja bolesti ključna je za osiguranje dobrobiti ljudi. Glodavci s kojima dijelimo i prirodna i urbana staništa rezervoari su niza uzročnika bolesti ljudi i drugih životinja (zoonoza). Stoga je potreba za sustavnim monitoringom glodavaca kao i drugih sitnih sisavaca i njihovih zoonoza od izuzetne važnosti. Razvojem i implementiranjem novih metoda poput analize okolišne DNA omogućuje se brži, efikasniji i financijski prihvatljiviji način sustavnog monitoringa.Organizacija-domaćin: Univerza na Primorskem, Slovenija]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15740</id><title_hr><![CDATA[Dolazna mobilnost viših asistenata - Ida Delač]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5765</user_id><user_firstLast_name>Ida Delač</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOL</proposal_type><proposal_call>2023-08</proposal_call><code>MOBDOL-2023-08-2165</code><acronim><![CDATA[]]></acronim><duration>01.03.2024 - 31.12.2025</duration><status>U tijeku</status><financ_value>79.750,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut za fiziku]]></institution_hr><institution_en><![CDATA[Institute of Physics in Zagreb]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Krajnji znanstveno-istraživački očekivani cilj usavršavanja je proizvesti hibridni 2D materijal dobiven adsorpcijom organskih molekula na 2D TMD na grafenu na više različito interagirajućih i/ili korugiranih metalnih podloga. To će uključivati epitaksijalni rast TMD-a na supstratima prekrivenim grafenom, koji ukljucuju Ir(111), Ir(332) i Ni(111). U sklopu usavršavanja gostujući istraživač će usvojiti protokol za rast grafena na Ni(111), koji postoji u literaturi ali nije do sad provođen na IFZG, te na 1r(332), što je protokol razvijen na IFZG. Karakterizacija sintetiziranih materijala provoditi će se pod UHV uvjetima i u ambijentalnim okruženjima.Sinteza 2D-TMD-ova i metalnih supstrata prekrivenih grafenom u UHV uvjetima jamči njihovu visoku kvalitetu i nisku gustoću defekata, Kombinacija UHV i ambijentalnih tehnika karakterizacije omogućuje istraživanje elektroničkih, kemijskih, optičkih i strukturnih svojstava funkcionaliziranih 2D materijala. Osim toga, ispitivanje izdržljivosti materijala pod ambijentalnim uvjetima služi kao prvi test njihove mogućnosti za budući razvoj elektroničkih uređaja.Gostujući istraživač: dr. sc. Cosme Gonzalez Ayani]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15741</id><title_hr><![CDATA[Dolazna mobilnost viših asistenata - Maja Dutour Sikirić]]></title_hr><title_en><![CDATA[]]></title_en><user_id>224</user_id><user_firstLast_name>Maja Dutour Sikirić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOL</proposal_type><proposal_call>2023-08</proposal_call><code>MOBDOL-2023-08-2261</code><acronim><![CDATA[]]></acronim><duration>29.03.2024 - 28.03.2025</duration><status>U tijeku</status><financ_value>43.500,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Stabilne suspenzije nanomaterijala titanijevog dioksida ključ su uspješne i sigurne primjene velikog broja industrijskih i potrošačkih proizvoda (kozmetika, premazi, hrana). U velikom broju primjena najučinkovitiji način stabilizacije nanomaterijala je korištenje disperzanata, spojeva koji svojom adsorpcijom na površinu nanomaterijala sprječavaju agregaciju čestica. Usprkos velikom broju istraživanja različitih disperzanata za stabilizaciju nanomaterijala titanijevog dioksida, priprava stabilnih suspenzija za različite primjene još uvijek se temelji na metodi pokušaja i pogreške, što je vremenski i financijski zahtjevno.Cilj ovog projekta je istraživanjem brzine i mehanizama adsorpcije često korištenih disperzanata na nanomaterijale titanijevog dioksida doprinijeti razumijevanju procesa stabilizacije i parametara koji na njega utječu. Na taj način omogućio bi se lakši izbor odgovarajućeg disperzanta, što je od izuzetne važnosti kako u znanosti, tako i u gospodarstvu i očuvanju okoliša.Rad na temi od interesa za znanost i gospodarstvo, u međunarodnom okruženju, u sklopu projekta STOP, omogućit će mladom istraživaču upoznavanje s novim i naprednim tehnikama istraživanja, te uspostavu kontakata s drugim znanstvenim grupama i zainteresiranim tvrtkama, što će otvoriti nove mogućnosti napredovanja i razvijanja njegove istraživačke karijere.Gostujući istraživač: dr. sc. Ljiljana Spasojević]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15742</id><title_hr><![CDATA[Dolazna mobilnost viših asistenata - Željka Pezer Sakač]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1280</user_id><user_firstLast_name>Željka Pezer Sakač</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOL</proposal_type><proposal_call>2023-08</proposal_call><code>MOBDOL-2023-08-1822</code><acronim><![CDATA[]]></acronim><duration>15.03.2024 - 14.06.2025</duration><status>U tijeku</status><financ_value>54.375,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Strukturne varijante (inverzije, translokacije i varijacije u broju kopija) su dominantni oblik genetičkih varijacija. Zbog velikog udjela u genomu kojeg zahvaćaju i visoke stope mutacije, smatra se da imaju značajan utjecaj na fenotip, no nije jasno u kojoj mjeri na njih utječu okoliš i način života. Glavni cilj projekta je ustanoviti mogu li čimbenici poput prehrane i konzumacije alkohola izazvati promjene u učestalosti strukturnih varijacija u genomu reproduktivnih stanica. Takve se promjene mogu odraziti na zdravlje potomstva i evoluciju čitavih populacija. U ovom istraživanju, koje se provodi na modelu misa, po prvi puta u svijetu smo uspješno primijenili tehnologiju optičkog mapiranja za detekciju strukturnih varijanti u genomima spermijima, čime smo otvorili mogućnost novim primjenama ove tehnologije u području istraživanja evolucije i dijagnostici. Međutim, budući da je tehnologija optičkog mapiranja genoma dizajnirana prvenstveno za rad na ljudskom somatskom tkivu, potrebne su mnoge prilagodbe kako bi se mogla pouzdano primijeniti i na druge vrste. Osim optimizacije pripreme uzorka koja je dosad uspješno implementirana u projekt, pokazalo se da je potrebno prilagoditi algoritam za detekciju strukturnih varijanti kako bi se postigla veća preciznost i osjetljivost pri primjeni na genom misa. U sklopu usavršavanja na Institutu Ruđer Bošković, gostujući istraživač-biomatematičar će se baviti optimizacijom pristupa u detekciji strukturnih varijanti iz optičkih mapa genoma miša, koristeći se vještinama vezanima uz računalnu biologiju. Tijekom tog razdoblja steći će znanja i iskustvo u području istraživanja genomskih strukturnih varijacija, evolucijske biologije i evolucije genoma, te ovladati metodologijom obrade podataka dobivenih tehnologijom optičkog mapiranja genoma. Zbog novostečenog znanja, vještina i iskustva kroz rad na originalnom pristupu problematici, ovo će usavršavanje unaprijediti istraživačko-razvojne i inovacijske kapacitete gostujućeg istraživača ali i doprinijeti prijenosu znanja i vještina unutar Instituta. Osim toga, usavršavanje će doprinijeti stvaranju međunarodnih mreža te podizanju konkurentnosti i internacionalizaciji hrvatskog sustava istraživanja.Gostujući istraživač: dr. sc. Robert Schwieger]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15744</id><title_hr><![CDATA[Odlazna mobilnost viših asistenata - Dora Hlebec]]></title_hr><title_en><![CDATA[]]></title_en><user_id>28678</user_id><user_firstLast_name>Dora Hlebec</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBODL</proposal_type><proposal_call>2023-08</proposal_call><code>MOBODL-2023-08-8019</code><acronim><![CDATA[]]></acronim><duration>30.03.2024 - 29.03.2025</duration><status>U tijeku</status><financ_value>48.000,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[U doba masovnog izumiranja vrsta, ponajviše uzrokovanog antropogenim djelovanjem, više no ikada važno je usmjeriti pažnju na istraživanje bioraznolikosti globalno neistraženih skupina organizama, poput lažištipavaca. Lažištipavci (lat. Pseudoscorpiones), pripadaju razredu paučnjaka, zajedno sa štipavcima, paucima i krpeljima. Zbog svoje male veličine (1-10 mm), ali i medicinske nezanimlijivosti (u potpunosti su bezopasni za ljude), vrlo često nisu zamijećeni na svojim staništima, te su zanemarivani u znanstvenim istraživanjima. Identifikacija lažištipavaca do razine vrste zahtijeva visoku razinu taksonomske stručnosti zbog česte pojave homoplazije, morfološke sličnosti medu nesrodnim vrstama. Primjenom molekularnih metoda ta je identifikacija znatno olakšana. Unatoč dugoj tradiciji biospeleoloških istraživanja u Hrvatskoj, posebice na području Dinarida, svjetskom centru bioraznolikosti podzemne faune, lažištipavci su slabo istraženi. U okviru znanstveno-istraživačkog usavršavanja po prvi će puta na uzorcima lažištipavaca, i to upravo s područja Hrvatske, biti primijenjene nove metode sekvenciranja: sekvenciranje ultraočuvanih elemenata (engl. ultra-conserved elements, UCEs) i double-digest RAD sekvenciranje (engl. double-digest RAD sequencing, ddRADseq). Biogeografskim analizama na vrstama iz najučestalijih rodova Chthonius i Neobisium i primjenom metode molekularnog datiranja steći će se uvid u geomorfološku povijest Hrvatske, prvenstveno planinskog masiva Dinarida, a ddRAD sekvenciranjem pratit će se protok gena između populacija dviju srodnih vrsta roda Neobisium.Organizacija-domaćin: Universitat de Barcelona, Španjolska]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15746</id><title_hr><![CDATA[Odlazna mobilnost viših asistenata - Andrej Novak]]></title_hr><title_en><![CDATA[]]></title_en><user_id>17819</user_id><user_firstLast_name>Andrej Novak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBODL</proposal_type><proposal_call>2023-08</proposal_call><code>MOBODL-2023-08-7617</code><acronim><![CDATA[]]></acronim><duration>25.03.2024 - 24.03.2026</duration><status>U tijeku</status><financ_value>96.000,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Parcijalne diferencijalne jednadžbe (PDJ) su matematički alati koji se koriste za opisivanje raznih prirodnih fenomena poput valova, topline ili elektromagnetizma te nam pomažu razumjeti složene fizikalne procese i predvidjeti ponašanje sustava. U posljednjem desetljeću, PDJ se sve više koriste i u primijenjenom računarstvu, a posebno u području obrade digitalnih slika. Ovo usavršavanje se fokusira na razvoj novih metoda za uslikavanje i segmentaciju digitalnih slika temeljenih na PDJ. Osim teorijskih rezultata, postoji težnja za primjenama u medicinskim slikama kroz sinergiju PDJ s naprednim tehnikama strojnog učenja kako bi se postigla automatizirana segmentacija medicinskih slika. Glavni cilj je razviti nove algoritme za analizu i obradu velikih skupova medicinskih slika koji će e poboljšati preciznost i efikasnost identifikacije i prikaza anatomskih struktura na slikama, što bi moglo unaprijediti trenutne dijagnostičke i terapijske postupke. Spoj matematičkih metoda i metoda iz strojnog učenja će dati napredne alate za obradu i analizu medicinskih slika, što je od velikog interesa u području personalizirane medicine kao i napretka tehnologija medicinskog slikanja.Organizacija-domaćin: University of Vienna, Faculty of Mathematics, Austrija]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15748</id><title_hr><![CDATA[Odlazna mobilnost viših asistenata - Dinko Šoić]]></title_hr><title_en><![CDATA[]]></title_en><user_id>867379</user_id><user_firstLast_name>Dinko Šoić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBODL</proposal_type><proposal_call>2023-08</proposal_call><code>MOBODL-2023-08-6168</code><acronim><![CDATA[]]></acronim><duration>01.03.2024 - 31.03.2025</duration><status>U tijeku</status><financ_value>52.000,00 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Farmacija, </scie_field_hr><scie_field_en>Pharmaceutical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Farmaceutsko-biokemijski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Pharmacy and Biochemistry]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Ljudska crijeva dom su nevjerojatno velikog broja mikroorganizama, zajednički poznatih pod nazivom crijevna mikrobiota. Ovi mikrobi igraju ključnu ulogu u našem zdravlju utječući na probavu, imunološku funkciju, pa čak i na mentalno blagostanje. Među raznolikim stanovnicima crijeva prisutne su i komenzalne bakterije koje mirno koegzistiraju u našim tijelima te pomažu u razgradnji prehrambenih komponenti, sintetiziraju bitne vitamine i jačaju naš imunološki sustav. Posljednjih godina znanstvenici su počeli sve više proučavati nevjerojatan svijet crijevnih bakterija i njihovih složenih interakcija s našim tijelom. Jedan od intrigantnijih aspekata međudjelovanja tijela i bakterija odvija se preko ugljikohidratnih struktura prisutnih na njihovoj površini. Glikozilacija, proces koji uključuje dodavanje molekula šećera proteinima i lipidima, ima ključnu ulogu u mnogim biološkim procesima. U kontekstu komenzalnih bakterija, upravo proces glikozilacije omogućuje nadogradnju površinskih proteina i modificiranje njihovih struktura. Time se olakšava komunikacija bakterija sa stanicama naše crijevne sluznice te omogućuje učinak na naš imunološki sustav. Razumijevanje specifičnih glikanskih struktura uključenih u ovu komunikaciju ključno je za dešifriranje načina na koji crijevne bakterije doprinose našem cjelokupnom zdravlju. Ovo znanje moglo bi utrti put novim terapijskim strategijama usmjerenim na crijevnu disbiozu i poremećaje povezane s imunološkim sustavom, ali i pridonijeti razvitku novih vrsta biljega statusa crijevne mikrobiote. Upravo će se ovim usavršavanjem provesti karakterizacija do sada nedovoljno istraženih nepatogenih bakterijskih crijevnih vrsta te odrediti šećerne komponente specifične za određeni bakterijski soj. Također, predloženi projekt ima za cilj translatirati istraživanje glikozilacije na uzorke stolice, što će po prvi puta omogućiti karakterizaciju glikozilacije crijevnih komenzalnih mikrobiota koje nisu uzgojene u bioreaktoru. Čitav će se projekt provesti uz pomoć najsuvremenijih analitičkih rješenja, kao i najsofisticiranije opreme poput kromatografa ultra-visoke djelotvornosti i spektrometra masa visoke rezolucije. Podaci će biti analizirani korištenjem naprednih bioinformatičkih alata, a rezultati će predstavljati temelj za iskorištavanje ogromnog potencijala prokariotskih glikanskih struktura u terapijske i biomarkerske svrhe. Usavršavanje će rezultirati dodatnom ekspertizom mladog istraživača koji će stečene vještine translatirati u svoj svakodnevni rad, a svoje proširene interese produbit će daljnjim međunarodnim suradnjama i projektima.Organizacija-domaćin: Delft University of Technology, Nizozemska]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15750</id><title_hr><![CDATA[Odlazna mobilnost viših asistenata - Igor Karlović]]></title_hr><title_en><![CDATA[]]></title_en><user_id>25213</user_id><user_firstLast_name>Igor Karlović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBODL</proposal_type><proposal_call>2023-08</proposal_call><code>MOBODL-2023-08-4470</code><acronim><![CDATA[]]></acronim><duration>18.03.2024 - 17.03.2025</duration><status>U tijeku</status><financ_value>48.000,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Rudarstvo, nafta i geološko inženjerstvo, </scie_field_hr><scie_field_en>Mining, petroleum and geological engineering, </scie_field_en><institution_hr><![CDATA[Hrvatski geološki institut]]></institution_hr><institution_en><![CDATA[Croatian Geological Survey]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Nitrati su jedni od najčešćih onečišćivala podzemnih voda u svijetu. Visoke koncentracije nitrata uzrokuju degradaciju kakvoće podzemnih voda, što predstavlja ozbiljan ekološki, društveni i gospodarski problem. S obzirom da su jedni od glavnih izvora nitrata korištenje gnojiva u poljoprivrednoj proizvodnji te otpadne vode, područja s razvijenom poljoprivrednom aktivnosti te nerazvijenom kanalizacijskom mrežom su potencijalno ranjiva na onečišćenje nitratima. Primjer takvog područja je varaždinski vodonosnik, u kojem su dugoročna poljoprivredna aktivnost, industrija i rast stanovništva znatno utjecali na porast koncentracija nitrata u vodonosniku, što je izazvalo zabrinutost javnosti te povećalo interes lokalne zajednice za zaštitu podzemne vode. S obzirom da varaždinski vodonosnik osigurava pitku vodu za oko 170.000 stanovnika Varaždinske županije, neophodno je unaprijediti razumijevanje procesa transformacije dušika kako bi se postigla bolja karakterizacija nitrata u vodonosnom sustavu. Uže područje istraživanja predstavlja priljevno područje varaždinskog crpilišta Vinokovšćak gdje su u prijašnjim istraživanjima utvrđeni pokazatelji koji ukazuju na proces denitrifikacije, koji se smatra glavnim prirodnim procesom za smanjenje visokih koncentracija nitrata u podzemnim vodama. Glavni fokus usavršavanja je istraživanje uloge nezasićene zone koja se nalazi iznad razine podzemne vode na ponašanje i transport nitrata u vodonosniku te utjecaja potencijalnog procesa denitrifikacije na poboljšanje kakvoće vode. U okviru istraživanja testirat će se metodologija koja se bazira na numeričkom modeliranju pojedinih zona vodonosnog sustava, što omogućuje kvantifikaciju učinaka poljoprivredne djelatnosti na kakvoću podzemne vode te predstavlja učinkovit alat za formuliranje strategija upravljanja podzemnim vodama i mjera za smanjenje onečišćenja nitratima. Glavni ciljevi istraživanja uključuju: (i) Definiranje uloge površinskih voda na prihranjivanje crpilišta Vinokovšćak; (ii) Definiranje 3D modela heterogenosti vodonosnika; (iii) Definiranje uloge nezasićene zone na prihranjivanje crpilišta Vinokovšćak te raspodjelu i transport nitrata s površine terena do podzemne vode; (iv) Razvoj lokalnog modela tečenja podzemne vode i transporta nitrata u zasićenoj zoni crpilišta Vinokovšćak. Navedeni ciljevi osigurat će uvid u prostorno-vremensku raspodjelu nitrata, omogućiti predviđanja budućeg stanja kakvoće podzemne vode te dati konačnu ocjenu ima li proces denitrifikacije značajnu ulogu u smanjenju nitrata u priljevnom području crpilišta. Predloženo znanstvenoistraživačko usavršavanje ima potencijal korištenja u sličnim vodonosnim sustavima koji su opterećeni nitratima, pri čemu očekivani rezultati istraživanja predstavljaju osnovu za osiguravanje održivog upravljanja vodnim resursima i poljoprivrednom proizvodnjom.Organizacija-domaćin: Geološki zavod Slovenije]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15752</id><title_hr><![CDATA[Odlazna mobilnost viših asistenata - Anja Barić]]></title_hr><title_en><![CDATA[]]></title_en><user_id>25294</user_id><user_firstLast_name>Anja Barić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBODL</proposal_type><proposal_call>2023-08</proposal_call><code>MOBODL-2023-08-5631</code><acronim><![CDATA[]]></acronim><duration>31.03.2024 - 30.03.2025</duration><status>U tijeku</status><financ_value>48.000,00 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Fibromialgija je vodeći uzrok kronične boli, koja zahvaća vise od 2% svjetske populacije. Osim ozbiljnog utjecaja na kvalitetu života, pacijenti s fibromialgijom prolaze kroz dugi dijagnostički proces kako bi se isključile druge bolesti, a tijekom kojeg na osnovi subjektivnih osjećaja boli moraju druge uvjeriti da su bolesni budući da izgledaju zdravo. Lijekovi protiv bolova ne djeluju kod većine pacijenata, a liječenje je većinom usmjereno na vježbu i edukaciju pacijenta kako bi im se pomoglo da budu aktivni i da se nose s boli. Točan uzrok ove teške bolesti zasad nije poznat. Većina istraživača smatra da je fibromialgija sindrom boli u kojem prekomjerna aktivnost u središnjem živčanom sustavu dovodi do pogrešaka u obradi i interpretaciji boli koja je na taj način povećana. Međutim, nedavno je otkriveno da je imunološki sustav odgovoran za bol i mnoge druge simptome fibromialgije. Imunološki sustav proizvodi protutijela, proteine koji inače pomažu u obrani našeg organizma od bakterija, virusa, parazita i kancerogenih stanica. Nedavno je otkriveno da protutijela pacijenata koji pate od fibromialgije napadaju vlastito tijelo i živce, stvarajući neumoljivu bol i pretjeranu osjetljivost na osjetne podražaje. Cilj predloženog znanstveno-istraživačkog usavršavanja jest pomoću suvremenih metoda detekcije moždane aktivnosti na mišjem modelu bolesti istražiti dovodi li autoimuna reakcija i do promjena u moždanim područjima koja su zadužena za prijenos i obradu informacija o boli. Predviđa se da će rezultati ovog istraživanja promijeniti naše dosadašnje razumijevanje bolesti i doprinijeti novoj klasifikaciji fibromialgije kao autoimunog poremećaja te na taj način ubrzati razvoj dijagnostičkih metoda i učinkovitijih tretmana za milijune pogođenih ljudi. Originalna tematika, inovativna primjena suvremenih istraživačkih metoda te veliki klinički značaj očekivanih rezultata ovog usavršavanja omogućit će mladoj znanstvenici dr. sc. Anji Barić da kroz novostečene vještine i znanja te dugoročnu suradnju s izvrsnim inozemnim istraživačkim timom razvije kompetencije za međunarodno prepoznatljivu karijeru.Organizacija-domaćin: King&#39;s College London, Ujedinjena Kraljevina]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15753</id><title_hr><![CDATA[Odlazna mobilnost viših asistenata - David Rukavina]]></title_hr><title_en><![CDATA[]]></title_en><user_id>22540</user_id><user_firstLast_name>David Rukavina</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBODL</proposal_type><proposal_call>2023-08</proposal_call><code>MOBODL-2023-08-7444</code><acronim><![CDATA[]]></acronim><duration>28.03.2024 - 27.03.2025</duration><status>U tijeku</status><financ_value>48.000,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Geologija, </scie_field_hr><scie_field_en>Geology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Rudarsko-geološko-naftni fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mining, Geology and Petroleum Engineering]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Potreba za tranzicijom prema čistim izvorima energije i smanjenju ugljičnog otiska u atmosferi iziskuje detaljnije razumijevanje sedimentnih bazena, odnosno dijelova Zemljine kore prekrivenih debelim slijedom sedimentnih stijena. Analiza sedimentnih bazena predstavlja disciplinu u geologiji koja se bavi njihovim formiranjem i evolucijom. Sedimentni bazeni su iznimno važni jer njihovi sedimenti predstavljaju zapis Zemljine povijesti dok su bili aktivni. Također, predstavljaju jedne od najvažnijih izvora prirodnih resursa. Najnovije metode analize sedimentnih bazena predstavljene su kompjuterski potpomognutim numeričkim simulacijama više istovremenih geoloških procesa. Primjena ovakvih metoda izostaje na primjerima sedimentnih bazena u Republici Hrvatskoj, a i šire. Znanstveno-istraživačko usavršavanje planirano provedbom projekta „Kvantificiranje veza između sedimentacije, klimatskih varijacija i tektonike: 3D numeričko modeliranje i usporedba s opažanjima iz Jadranske regije (QSCT-3D-ADRIA)“ bavilo bi se stratigrafsko-termo-mehaničkim numeričkim modeliranjem na primjeru hrvatskog dijela Jadranskog predgorskog bazena. Projekt obuhvaća analizu sedimentnog bazena temeljenu na geološkim i geofizičkim podatcima. Pri tome je objekt istraživanja postavljen kroz proučavanje pliocenskih do recentnih (5,3 — 0 milijuna godina) sedimenata, u odobalju Srednjeg i Južnog Jadrana. Projekt bi se ostvario u suradnji s Geophysical Fluid Dynamics grupom na Department of Earth Sciences na ETH Zürich.Ovim projektom prvenstveno se planira ostvariti prijenos najsuvremenijih znanja, metoda, vještina i alata primjenom metoda stratigrafsko-termo-mehaničkog numeričkog modeliranja sedimentnih bazena. One omogućuju procjenu evolucije bazena simulacijom različitih procesa, poput tektonike, dinamike Zemljinog plašta, erozije, taloženja i klimatskih varijacija. Kvantitativno razumijevanje toplinske evolucije bazena omogućava smanjenje rizika procjene geotermalnog potencijala. Stratigrafsko modeliranje distribucije sedimenata smanjuje rizik prilikom identifikacije građe podzemlja, što je iznimno važno za sve geoenergetske sustave (npr. definiranja lokacija objekata za skladištenje energije ili CO2). Projekt će omogućiti rekonstrukciju nove, detaljne krivulje razine Jadranskog mora u zadnjih 5 milijuna godina. Time će se ostvariti značajan doprinos analizi klimatskih promjena i njihove interakcije s ostalim geodinamskim procesima te dati osvrt na utjecaj na živi svijet.Organizacija-domaćin: ETH Zurich, Švicarska]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15754</id><title_hr><![CDATA[Dolazna mobilnost viših asistenata - Marija Cerjak]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3970</user_id><user_firstLast_name>Marija Cerjak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOL</proposal_type><proposal_call>2023-08</proposal_call><code>MOBDOL-2023-08-5529</code><acronim><![CDATA[]]></acronim><duration>15.02.2024 - 14.02.2026</duration><status>U tijeku</status><financ_value>87.000,00 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Agronomski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Agriculture]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[lako je poznata izravna veza između prehrane i zdravlja, veliki broj ljudi, posebice mladih ne vodi dovoljno brige o kvaliteti svoje prehrane, što dovodi do brojnih zdravstvenih problema poput pretilosti, bolesti srca, dijabetesa i sl. Brojna znanstvena istraživanja su pokazala da mediteranska prehrana ima pozitivan utjecaj na ljudsko zdravlje, ali i da se potrošači, uključujući i studente uglavnom ne pridržavaju mediteranske prehrane. Dosadašnje studije koje su proučavale ponudu hrane u kantinama, uključujući i studentske menze su pokazale da su ponuđeni obroci često neuravnoteženi i daleko od mediteranskog obrasca prehrane. Cilj ovog usavršavanja je utvrditi percepciju različitih dionika o mediteranskoj prehrani u studentskim menzama, utvrditi prehrambene navike, stavove i zadovoljstvo studenata s postojećom ponudom hrane u studentskim menzama te njihovu zainteresiranost za obrocima usklađenima s mediteranskom prehranom u menzama. Istraživanje će poslužiti za izradu marketinške strategije koja može poslužiti kao podloga za promjenu studentske prehrane prema zdravijoj i održivijoj prehrani, što je posebice važno uzme li se u obzir udio pretilih osoba, posebice mladih u ukupnoj populaciji.Usavršavanje gostujućeg istraživača će doprinijeti jačanju njegovih znanstvenih kapaciteta u području kvalitativnih i kvantitativnih marketinških istraživanja te njegovu bolju integraciju u znanstvenoistraživački prostor domaćih i međunarodnih znanstvenika.Gostujući istraživač: dr. sc. Ivica Faletar]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15755</id><title_hr><![CDATA[Odlazna mobilnost viših asistenata - Marcela Konjevod]]></title_hr><title_en><![CDATA[]]></title_en><user_id>23665</user_id><user_firstLast_name>Marcela Konjevod</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBODL</proposal_type><proposal_call>2023-08</proposal_call><code>MOBODL-2023-08-1755</code><acronim><![CDATA[]]></acronim><duration>18.03.2024 - 17.03.2025</duration><status>U tijeku</status><financ_value>48.000,00 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Shizofrenija je kroničan neuropsihijatrijski poremećaj, koji pogađa oko 1% svjetske populacije te predstavlja ozbiljan, svjetski zdravstveni problem. Unatoč brojnim istraživanjima, složena etiologija shizofrenije još je uvijek nejasna, što znatno otežava liječenje, neophodno za normalno društveno funkcioniranje. Pronalazak prediktivnih, prognostičkih ili dijagnostičkih biomarkera bilo kojeg neuropsihijatrijskog poremećaja, uključujući shizofreniju, je vrlo složen jer molekularna podloga takvih bolesti uključuje kompleksnu interakciju genetskih i okolišnih čimbenika. Stoga, metabolomika kao brzorastuća znanstvena disciplina može pružiti uvid u promijenjene metabolite, koji reflektiraju različite okolišne utjecaje stres, prehrana, lijekovi) i odgovarajuće metaboličke puteve kod osoba sa shizofrenijom. Korištenje tri različite analitičke tehnike te primjena različitih statističkih/matematičkih alata omogućit će bolje razumijevanje kemijsko-bioloških interakcija koje vode k razvoju shizofrenije, definiranju panela potencijalnih biomarkera te identifikaciji potencijalnih terapijskih meta. Kombinacija novostečenih znanja iz biomedicine, analitičke kemije i kemometrije trebala bi doprinijeti rasvjetljavanju kompleksne etiologije shizofrenije, ali i drugih kompleksnih neuropsihijatrijskih bolesti.Organizacija-domaćin: University of Basque Country, Španjolska]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15759</id><title_hr><![CDATA[Odlazna mobilnost viših asistenata - Mavro Lučić]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5151</user_id><user_firstLast_name>Mavro Lučić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBODL</proposal_type><proposal_call>2023-08</proposal_call><code>MOBODL-2023-08-5702</code><acronim><![CDATA[]]></acronim><duration>29.07.2024 - 18.09.2025</duration><status>U tijeku</status><financ_value>72.000,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Interdisciplinarne prirodne znanosti, </scie_field_hr><scie_field_en>Interdisciplinary natural sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Sintetizirane nanočestice ulaze u važnu skupinu tzv. novih tipova zagađivala (engl. emerging contaminants), koje karakteriziraju male dimenzije i velika specifična površina, a time i sposobnost prodiranja u stijenke bioloških stanica, što ih čini potencijalnom ugrozom za ljudsko zdravlje. O njihovim koncentracijama, sastavu i ponašanju u realnim okolišnim uvjetima jako se malo zna, uglavnom zbog neodgovarajućih analitičkih tehnika koje bi omogućile njihovu jednostavnu i točnu analizu. Glavnina postojećih studija bavi se otpadnom vodom ili analiziraju samo jedan tip metala/metalnih oksida (npr. najčešće Ag ili TiO2) bez poznavanja kompletnog sastava nanočestica, što uključuje razlikovanje sintetiziranih od prirodnih nanočestica te razlikovanje različitih antropogenih izvora SN-a. Uostalom, razlikovanje SN-a od PN-a, temelj je okolišne nanoanalitike i svaka daljnja procjena rizika za okoliš koja to ne uzima u obzir može biti pogrešna. Prema našim saznanjima, nijedna studija dosad nije uzela u obzir problematiku složenog sastava nanočestica u čvrstim matricama (npr. biokrutinama ili tlu), što je presudno za njihovu točnu identifikaciju i pouzdana mjerenja.Ovo usavršavanje pridonijet će novim saznanjima kroz razvoj analitičke metode za analizu nanočestica u biokrutinama, koristeći najsuvremeniji instrument za njihovu okolišnu karakterizaciju u pogledu sastava i raspodjele, sp-ICP-TOFMS. Prije početka usavršavanja, uzorci biokrutina biti će uzorkovani u tri UPOV-a, s kojima su mladi istraživač i njegov mentor na IRB-u prethodno dobro surađivali: (i) UPOV Zagreb, (ii) Velika Gorica i (iii) Sisak. Pritom će glavne inovativnosti analitičke metode, uz važnost medija uzorkovanja, biti po prvi puta kalibracija u matrici uzorka pomoću generatora mikrokapljica, što će omogućiti pouzdanu i točnu analizu nanočestica u biokrutinama. Zatim, metode statističkoga učenja bit će korištene u svrhu razlikovanja PN-a od SN-a te određivanja raznih antropogenih izvora SN-a. Njihovom primjenom, cilj je razviti nove alate koji će omogućiti utvrđivanje porijekla nanočestica u biokrutinama, a omogućit će i njihovu prenamjenu i u istraživanju drugih okolišnih medija.Organizacija-domaćin: Federal Institute for Materials Research and Testing, Berlin, Njemačka]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15760</id><title_hr><![CDATA[Odlazna mobilnost viših asistenata - Bogdan Okreša Đurić]]></title_hr><title_en><![CDATA[]]></title_en><user_id>17828</user_id><user_firstLast_name>Bogdan Okreša Đurić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBODL</proposal_type><proposal_call>2023-08</proposal_call><code>MOBODL-2023-08-5618</code><acronim><![CDATA[]]></acronim><duration>15.02.2024 - 14.06.2025</duration><status>U tijeku</status><financ_value>64.000,00 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Informacijske znanosti, </scie_field_hr><scie_field_en>Information sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet organizacije i informatike]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Organization and Informatics]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Mladi istraživač dr. sc. Bogdan Okreša Đurić, član Laboratorija za umjetnu inteligenciju (Al Lab) Sveučilišta u Zagrebu Fakulteta organizacije i informatike, provodi 16 mjeseci na znanstveno-istraživačkom usavršavanju kao gost mentora-domaćina profesora Vicentea Juana Bottija Navarra, renomiranog znanstvenika i voditelja Valencian Research Institute for Atificial Intelligence (VRAIN) na Universitat Politécnica de Valéncia u Španjolskoj. VRAIN je jedan od najvećih španjolskih instituta koji se bave umjetnom inteligencijom i na razini EU prepoznat centar izvrsnosti za umjetnu inteligenciju. Program Bogdanovog usavršavanja fokusira se na proučavanje modeliranja znanja, umjetnih agenata i višeagentnih sustava te igrifikacije. U suradnji s vrsnim znanstvenicima organizacije-domaćina, Bogdan planira proširiti svoje znanje, dodatno internacionalizirati mrežu suradnika te detaljnije upoznati modeliranje temeljeno na agentima, simulacije održive mobilnosti i igrifikaciju. Pozitivan utjecaj ovog usavršavanja očekivan je i za Al Lab i za nastavnike Fakulteta, a svakako i za njegove studente svih razina studija.Organizacija-domaćin: Valencian Research Institute for Artificial Intelligence, Španjolska]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15761</id><title_hr><![CDATA[Odlazna mobilnost viših asistenata - Saša Marcinek]]></title_hr><title_en><![CDATA[]]></title_en><user_id>23224</user_id><user_firstLast_name>Saša Marcinek</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBODL</proposal_type><proposal_call>2023-08</proposal_call><code>MOBODL-2023-08-7181</code><acronim><![CDATA[]]></acronim><duration>27.03.2024 - 26.02.2026</duration><status>U tijeku</status><financ_value>92.000,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Interdisciplinarne prirodne znanosti, </scie_field_hr><scie_field_en>Interdisciplinary natural sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Istraživanje dr. sc. Marcinek &#39;Tehnološki kritični elementi: od biogeokemijskog kruženja u vodama Antarktike do biološkog utjecaja u uvjetima budućeg oceana (TCEbioMar)&#39; usredotočuje se na proučavanje posebne skupine kemijskih elemenata, tzv. tehnološki kritični elementi, poput cerija, gadolinija, lantana, elemenata iz platinske skupine, ali i mnogih drugih, a koji su posljednjih godina postali sastavni dio novih tehnologija u područjima telekomunikacije, medicine, transporta i energetike. Prema trenutnom trendu, sve veće emisije ovih elemenata u okoliš su činjenica, što izaziva zabrinutost oko njihove toksičnosti za okoliš i organizme te, u krajnjoj liniji, utjecaja na zdravlje ljudi. Unatoč rastućem značaju ovih elemenata u morskim ekosustavima kao njihovom krajnjem odredištu, naše znanje o njihovim točnim utjecajima ograničeno je brojnim nepoznanicama o njihovim izvorima, unutarnjem kruženju i biološkim efektima, što je osobito činjenično u specifičnim morskim sustavima, uključujući polarne regije. Jedan cilj ovog istraživanja je dublje razumjeti ulazne i izlazne putove ovih elemenata te procese koji utječu na njihovo kruženje u ekosustavu Otoka Deception na Antarktici. Specifičnost ovog sustava omogućava proučavanje ponašanja ovih elemenata pod utjecajem različitih okolišnih faktora u isto vrijeme uključujući otapanje Iedenjaka, hidrotermalnu i vulkansku aktivnost, planktonske vrste i aktivnost pingvina kao ključne životinje u ovom ekosustavu. Budući da je u nedavnim studijama potvrđena prisutnost ovih elemenata zarobljenih u slojevima leda na Antarktici, ovim istraživanjem procijenit će se rizik od njihovog unosa u obalne vode Antarktike obzirom na porast otapanja ledenjaka koji se očekuje s daljnjim napretkom klimatskih promjena. Nadalje, procijenit će se važnost hidrotermalne aktivnosti kao potencijalno važnog, a do sad nepotvrđenog prirodnog izvora ovih elemenata u oceane, njihova interakcija s lokalnim planktonskim zajednicama i doprinos pingvina njihovom unosu u vode otoka Deception te, konačno, izmjena ovih elemenata između istraživanog ekosustava i Južnog oceana. Drugi važan cilj ovog istraživanja je razumjeti utjecaj tehnološki kritičnih elemenata na morske organizme. Trenutačno nema regulatornih informacija ili ograničenja koncentracija ovih elemenata u morskoj vodi, međutim, moramo biti svjesni da kada sadržaj ovih elemenata u okolišu ili morskim organizmima, posebno onima koje konzumiramo u prehrani, prijeđe određeni prag (iako on još nije definiran) mogu pokazati toksične učinke. Stoga će se u drugom dijelu istraživanja provesti opsežna ekotoksikološka ispitivanja koja će dati odgovore na potencijalan rizik za morske organizme u slučaju povišenih koncentracija ovih elemenata u sadašnjim uvjetima u moru, ali i uzimajući u obzir izgledne promjene ovih uvjeta uzrokovane klimatskim promjenama, poput kiselijeg i toplijeg oceana. U konačnici, očekivani rezultati ovog istraživanja pružit će dublje razumijevanje ponašanja i utjecaja tehnološki kritičnih elemenata u moru, identificirati potencijalne rizike te doprinijeti razvoju smjernica za prilagodbu na buduće promjene i donošenju odluka i zakonskih regulativa u vezi s njihovim ekološkim učincima.Organizacija-domaćin: Institute of Marine Science of Andalusia, Španjolska]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15763</id><title_hr><![CDATA[Odlazna mobilnost viših asistenata - Ivana Coha]]></title_hr><title_en><![CDATA[]]></title_en><user_id>19321</user_id><user_firstLast_name>Ivana Coha</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBODL</proposal_type><proposal_call>2023-08</proposal_call><code>MOBODL-2023-08-3540</code><acronim><![CDATA[]]></acronim><duration>01.02.2024 - 31.01.2025</duration><status>U tijeku</status><financ_value>48.000,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Praćenje stanja radioaktivnosti u okolišu bitno je radi očuvanja zdravlja i okoliša. Moderne tehnike omogućuju razvoj brzih i jednostavnijih metoda, koje same bitno utječu na smanjenje zagađenja okoliša, ali i mogu dati znatno brže odgovore na pitanja je li utjecaj radioaktivnog zračenja značajan u određenom trenutku. Raspolaganje takvim metodama je nužno, posebice u akcidentnim situacijama kada je bitno na vrijeme informirati javnost o razini radiološkog zagađenja. Također, temeljna istraživanja koja su usmjerena na precizno i točno određivanje prirodnih, dugoživućih radionuklida su nužna kako bi znali odrediti prirodnu dozu zračenja koju primi stanovništvo. Kako je najmlađa populacija i najosjetljivija, istraživanja su usmjerena na razvoj metode određivanja prirodnih radionuklida urana, torija i radija u vodi i mlijeku odnosno hrani korištenjem masene spektrometrije (ICP-MS). U odnosu na postojeće metode očekuje se značajno skraćenje vrijeme analize s nekoliko dana na svega nekoliko sati, mogućnost ispitivanja puno većeg broja uzoraka uz znatno manju potrebnu količinu samog uzorka, smanjenje korištenja kemikalija i proizvodnje otpada. Dosad istraživanja transfera (prijelaza) radionuklida u majčino mlijeko nije sustavno i direktno ispitivano jer nisu postojale dovoljno osjetljive tehnike i metode, već su se koristili razni matematički modeli. Sama metoda bit će temelj za daljnja istraživanja i razvoj novih metoda određivanja ne samo prirodnih već i umjetnih radioizotopa koji dospijevaju u naš okoliš ljudskim djelovanjem.Stečena znanja bit će prenesena i uvedena u Hrvatsku te primijenjena za razvoj brzih metoda kojima je nužno raspolagati, pri rutinskom monitoringu u okolici nuklearnih objekata, skladištima nuklearnog otpada te posebice u slučaju nuklearnih nesreća ili napada. Izračunate doze unutar ovog istraživanja bit će vrlo vrijedna podloga za poznavanje doza dobivenih iz prirodnih izvora te bolje procjene u slučaju izvanrednih okolnosti koliko se dojenče ili dijete hranjeno adaptiranim mlijekom može ozračiti ovisno o razini radiološke kontaminacije iz umjetnih izvora. Takav pristup se može primijeniti i na svu populaciju, primjerice u slučaju ako će biti potrebno kontrolirati uvoz namirnica iz kontaminiranog područja.Organizacija-domaćin: Institut Jožef Stefan, Slovenija]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15764</id><title_hr><![CDATA[Odlazna mobilnost viših asistenata - Danko Relic]]></title_hr><title_en><![CDATA[]]></title_en><user_id>22557</user_id><user_firstLast_name>Danko Relic</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBODL</proposal_type><proposal_call>2023-08</proposal_call><code>MOBODL-2023-08-7557</code><acronim><![CDATA[]]></acronim><duration>30.03.2024 - 30.06.2025</duration><status>U tijeku</status><financ_value>60.000,00 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Javno zdravstvo i zdravstvena zaštita, </scie_field_hr><scie_field_en>Public health and health services, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Fokus istraživanja je poboljšanje položaja javnozdravstvene radne snage u Europi. Javno zdravstvo se bavi očuvanjem i unapređenjem zdravlja ljudi — od prevencije bolesti do promicanja zdravih životnih navika. Međutim, kako se društvo mijenja, tako se mijenjaju i izazovi s kojima se suočava javno zdravstvo. Aktivnosti u sklopu znanstveno-istraživačkog usavršavanja fokusiraju se na razumijevanje navedenih izazova i pronalazak načina kako profesionalci u javnom zdravstvu mogu biti bolje osposobljeni za suočavanje s njima. Ovo istraživanje će pružiti novi uvid u načine kako se može unaprijediti stručnost i profesionalizacija ljudi koji rade u javnom zdravstvu. Proučavanjem najboljih praksi na europskoj i globalnoj razini, istražit će se kako je moguće osigurati da zdravstveni stručnjaci imaju potrebna znanja i vještine za suočavanje s rastućim izazovima u modernom društvu. Ovo će pomoći osigurati kvalitetniju i dostupniju zdravstvenu skrb, poboljšati zdravlje i dobrobit populacije.Kvalitetniji profesionalci u javnom zdravstvu znače bolje odgovore na izazove kao što su epidemije, pandemije, potresi, poplave, kronične (zarazne i nezarazne) bolesti te promicanje zdravog načina života. Osim toga, profesionalizacija će doprinijeti učinkovitijim zdravstvenim sustavima, što ima pozitivan utjecaj i na gospodarstvo. Kroz ovaj istraživački projekt, nastoji se osnažiti profesionalce u javnom zdravstvu, promicati bolje zdravlje u društvu i ostvariti pozitivan utjecaj na zajednicu.Organizacija-domaćin: The Association of Schools of Public Health in the European Region (ASPHER), Belgija]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15766</id><title_hr><![CDATA[Odlazna mobilnost viših asistenata - Ivona Bečeheli]]></title_hr><title_en><![CDATA[]]></title_en><user_id>23790</user_id><user_firstLast_name>Ivona Bečeheli</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBODL</proposal_type><proposal_call>2023-08</proposal_call><code>MOBODL-2023-08-1077</code><acronim><![CDATA[]]></acronim><duration>01.03.2024 - 28.02.2025</duration><status>U tijeku</status><financ_value>48.000,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Majčina pretilost je rizični čimbenik za pojavu raznih komplikacija u trudnoći čija patofiziologija nerijetko uključuje poremećenu funkciju posteljice. Najčešći primjer takve komplikacije je intrauterični zastoj u rastu (IUGR), usporen rast fetusa u nepovoljnim uvjetima u trudnoći. Pravilan rast i razvoj fetusa zahtijeva uravnoteženu aktivnost različitih proteina iz posteljice, poput faktora rasta te proteina uključenih u serotoninsku signalizaciju i stanični metabolizam. Dosadašnja istraživanja pokazuju da su promjene u ekspresiji navedenih proteina u posteljici povezane s IUGR i majčinom pretilošću. Dakle, njihova ekspresija u posteljici bi mogla biti poremećena zbog majčine pretilosti, što bi potencijalno dovelo do pojave IUGR. Osim u posteljici, ekspresija navedenih proteina mogla bi se promijeniti i u fetalnim tkivima (mozgu i jetri). Navedeno bi se istražilo mjerenjem razine ekspresije odabranih proteina u posteljici te fetalnom mozgu i jetri mišjeg modela majčine pretilosti uzrokovane prehranom kod kojeg se u potomstva javlja IUGR. U istom modelu istražile bi se promjene u strukturi tkiva te ispitali potencijalno poremećeni stanični putevi u posteljici. Saznanja o potencijalno povezanim ulogama serotoninske ravnoteže i staničnog metabolizma posteljice kao posrednika i modulatora utjecaja majčine pretilosti na zdravlje potomaka bi mogla doprinijeti boljem razumijevanju mehanizama u pozadini poremećaja u fetalnom rastu.Organizacija-domaćin: University of Cambridge, Ujedinjena Kraljevina]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15768</id><title_hr><![CDATA[Odlazna mobilnost viših asistenata - Josip Parat]]></title_hr><title_en><![CDATA[]]></title_en><user_id>23208</user_id><user_firstLast_name>Josip Parat</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBODL</proposal_type><proposal_call>2023-08</proposal_call><code>MOBODL-2023-08-9122</code><acronim><![CDATA[]]></acronim><duration>31.03.2024 - 30.03.2025</duration><status>U tijeku</status><financ_value>48.000,00 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Arheologija, </scie_field_hr><scie_field_en>Archeology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Tema ovog znanstveno-istraživačkog usavršavanja rimski su grobni spomenici s natpisima iz provincije Donje Panonije. Domaćin je usavršavanja Francuska škola u Rimu (Ecole francaise de Rome), ugledna ustanova s dugom tradicijom arheoloških i povijesnih istraživanja. Glavni cilj usavršavanja jest značajno unaprijediti razumijevanje rimske epigrafske kulture na zacrtanom prostoru. Usporednim istraživanjem svih sastavnica spomenika nastoji se dobiti nijansiran uvid u njihova obilježja. Zahvaljujući brojnosti i kakvoći podataka, antička funerarna grada nudi izvanredne istraživačke mogućnosti. Prostor Hrvatske i obližnjih krajeva baštini golemu količinu ovakvih spomenika. Uz natpise, znanstvenici istražuju oblike spomenika, likovne prizore i arheološki kontekst. Ne bi li se razjasnila sva slojevitost rimske kulture podizanja grobnih spomenika, ovo istraživanje usmjereno je na tumačenje svih navedenih sastavnica.Glavna istraživačko pitanje jest u kojoj se mjeri građa iz Donje Panonije na formalnoj i sadržajnoj razini podudara s istovrsnom građom iz Rima, ltalije i zapadnih pokrajina Rimskoga Carstva. Tijekom usavršavanja prikupit će se, sistematizirati i znanstveno obraditi spomenici podignuti od uspostave do sloma rimske uprave (1-4. stoljeće). Doprinos usavršavanja humanističkom području očituje se u tome što će u okviru znanstveno utemeljenog epigrafskog istraživanja razjasniti komemorativnu praksu u životu antičkog čovieka. Analizom obilježja rimskih epitafa moći će se objasniti kako su tekle prilagodba i transformacija lokalnih zajednica u dodiru s Rimljanima, kako su i zašto pojedine tradicije preživjele, što je prilagođeno novim ukusima i kakvu su ulogu u tim procesima imali grobni spomenici. Očekuje se da će usavršavanje rezultirati monografskom publikacijom. Rezultati će doprinijeti boljem vrednovanju bogate epigrafske i uopće arheološke baštine u Hrvatskoj. Dobivene spoznaje bit će namijenjene najširoj zainteresiranoj publici. Shodno tomu valja imati u vidu njihov didaktički, turistički i opći društveni potencijal.Organizacija-domaćin: Ecole francaise de Rome, Italija]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15769</id><title_hr><![CDATA[Odlazna mobilnost viših asistenata - Anđela Buljan]]></title_hr><title_en><![CDATA[]]></title_en><user_id>867435</user_id><user_firstLast_name>Anđela Buljan</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBODL</proposal_type><proposal_call>2023-08</proposal_call><code>MOBODL-2023-08-8099</code><acronim><![CDATA[]]></acronim><duration>09.02.2024 - 08.02.2025</duration><status>U tijeku</status><financ_value>48.000,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Agar drvo (ili alojevo drvo, orlovo drvo) je smolasto zaraženo stablo akvilarije (Aquilaria sp.), koje raste u tropskim šumama jugoistočne Azije. Kada akvilariju napadne plijesan i ošteti deblo, drvo kao rezultat obrambenog odgovora biljke počinje proizvoditi molekule specifičnog mirisa. Vrlo specifičan miris agar drva opisao je Roman Kaisera, poznati stručnjak za mirise iz tvrtke Givaudan, kao „jedan od najfascinantnijih mirisa ovog svijeta (...) prodoran, tajanstven, prekrasan miris, koji spaja na jednostavan način mirise svih nezamislivih dragocjenih drva, balzama i smola, kao i onih jantara, mošusa i kastoreuma, i pomalo skrivenih, čak i nježnih cvjetnih nota“. Kemijski sastav njegovog hlapljivog dijela karakterizira kompleks sastavljen od seskviterpenskih sastojaka, a identitet njegovih ključnih mirisa još uvijek je predmet mnogih rasprava. S obzirom da prirodni resursi ne mogu zadovoljiti potrebe parfumerijske industrije, istraživanja se usmjeravaju na razvoj sintetskih protokola za pripravu ključnih komponenti eteričnog ulja agar drva, koje zbog zanimljivih i specifičnih olfaktornih svojstava svoju primjenu pronalaze u parfumerijskoj industriji. Ovaj projektni prijedlog uključuje sintezu i strukturnu karakterizaciju seskviterpenskih sastojaka eteričnog ulja agar drva uz razvoj kromatografskih tehnika za razdvajanje enantiomera na polisaharidnim kiralnim nepokretnim fazama, određivanje apsolutne konfiguracije i karakterizaciju olfaktornih svojstava primjenom vezanog sustava GC/MS spregnutog s olfaktometrom. Istraživanja se provode u suradnji s parfumerijskom industrijom. Očekuje se da će ovo znanstveno usavršavanje dati bolji uvid u kemiju seskviterpenoida i njihova olfaktorna svojstva, ključne sastojke eteričnog ulja agar drva, koji svoju primjenu pronalaze u parfumerijskoj industriji. Također se očekuje uspostavljanje novih suradnji sa znanstvenim institucijama i poslovnim sektorom, ali izobrazba poslijedoktorandice radom u međunarodnom okruženju, što će dodatno ojačati naš tim na organizaciji-prijavitelju.Organizacija-domaćin: Université Cote d&#39;Azur, Nica, Francuska]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15770</id><title_hr><![CDATA[Odlazna mobilnost viših asistenata - Mate Damić]]></title_hr><title_en><![CDATA[]]></title_en><user_id>861632</user_id><user_firstLast_name>Mate Damić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBODL</proposal_type><proposal_call>2023-08</proposal_call><code>MOBODL-2023-08-7021</code><acronim><![CDATA[]]></acronim><duration>20.03.2024 - 19.03.2025</duration><status>U tijeku</status><financ_value>48.000,00 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, </scie_field_hr><scie_field_en>Economy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Ekonomski fakultet u Zagrebu]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Economics and Business]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Razlike u pristupu sustavima upravljanja kvalitetom u zdravstvu dovode do heterogenih učinaka u smislu ekonomske, društvene i ekološke održivosti zdravstvenih organizacija. Dosadašnja znanstvena istraživanja nisu u dovoljnoj mjeri dala odgovor na pitanje u kojoj mjeri i na koji način dolazi do ovih razlika te na koji način se kroz različite načine i razine primjene sustava upravljanja kvalitetom može utjecati na postizanje veće razine održivosti zdravstvenih organizacija koje se suočavaju sa nizom značajnih izazova: održivosti financiranja, povećanja broja kroničnih bolesti, starenja stanovništva, nejednakosti u ostvarivanju prava na zdravstvenu skrb te porastima troškova lijekova i zdravstvene opreme. Cilj ovog usavršavanja je u suradnji sa znanstvenicima sa vodeće međunarodne institucije za istraživanja iz područja upravljanja u zdravstvu i ekonomike zdravstva, Universita Bocconi - Centre for Research on Health and Social Care Management (CERGAS) dati odgovor na pitanje kako sustavi upravljanja kvalitetom u zdravstvu utječu na održivost zdravstvenih organizacija u različitim zdravstvenim sustavima, kreirati instrument za procjenu cjelokupne održivosti zdravstvenih organizacija koji će omogućiti njihovu međusobnu usporedbu te napisati preporuke za povećanje razine održivosti ovih organizacija usmjerene ka donositeljima odluka u zdravstvu, ali i široj znanstvenoj i stručnoj zajednici.Organizacija-domaćin: Universita Bocconi - Centre for Research on Health and Social Care Management, Italija]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15771</id><title_hr><![CDATA[Odlazna mobilnost viših asistenata - Marina Marinović]]></title_hr><title_en><![CDATA[]]></title_en><user_id>25221</user_id><user_firstLast_name>Marina Marinović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBODL</proposal_type><proposal_call>2023-08</proposal_call><code>MOBODL-2023-08-9551</code><acronim><![CDATA[]]></acronim><duration>29.03.2024 - 28.03.2025</duration><status>U tijeku</status><financ_value>48.000,00 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Farmacija, </scie_field_hr><scie_field_en>Pharmaceutical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Farmaceutsko-biokemijski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Pharmacy and Biochemistry]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Prema procjenama Svjetske zdravstvene organizacije rak je u 2020. godini uzrokovao gotovo 10 milijuna smrtnih slučajeva diljem svijeta, što ga čini drugim vodećim uzrokom smrti. Budući da neselektivnost i razvoj rezistencije dovode do neželjenih djelovanja i smanjenja učinkovitosti kemoterapije, od iznimne je važnosti ulaganje u istraživanje novih meta i novih, učinkovitijih i sigurnijih citostatika. Galektin-8 je jedan od 15 članova obitelji galektina, proteina koji se ističu po svojoj sposobnosti specifičnog prepoznavanja B-galaktozidnih jedinica glikokonjugata. Zahvaljujući tome uključen je u brojne fiziološke i patofiziološke procese, što ga čini potencijalnom metom za liječenje brojnih bolesti, uključujući i određene vrste raka. Predloženo usavršavanje temelji se na nedavnim istraživanjima koja su pokazala kako u N-kraju domene koja prepoznaje ugljikohidrate (engl. carbohydrate recognition domain, CRD) postoji tzv. „selektivni džep” koji je karakterističan samo za galektin-8, što pruža mogućnost za razvoj selektivnijih i učinkovitijih inhibitora galektina-8. U svrhu toga, najprije će se provesti računalno potpomognuto dizajniranje na temelju kojega će se odabrati i sintetizirati knjižnica spojeva te će se ispitati afiniteti vezanja novih spojeva za N-kraj CRD galektina-8 tehnikom fluorescencijske polarizacije. Osim toga, dizajnirat će se nove fluorescentne probe jednostavnijeg sintetskog puta koje će se potom sintetizirati i koristiti u svrhu ispitivanja afiniteta vezanja novosintetiziranih inhibitora za galektin-8.Budući da su malobrojni publicirani inhibitori galektina-8 nedovoljno selektivni, s afinitetom vezanja u mikromolarnom koncentracijskom području, očekivani rezultati predloženog usavršavanja bit će od velike važnosti za daljnji razvoj potencijalnih citostatika. Provedba predloženog usavršavanja imala bi važan društveni i gospodarski utjecaj jer bi se razvojem selektivnih i učinkovitih inhibitora galektina-8 omogućila validacija galektina-8 kao terapijske mete, što bi potencijalno dovelo do razvoja novih i učinkovitijih lijekova i to ne samo u terapiji raka već i u terapiji infektivnih i autoimunih bolesti.Predloženo usavršavanje uključuje interdisciplinarna istraživanja i međunarodnu suradnju. Doprinijet će transferu znanja i metoda te omogućiti ostvarivanje potencijalne suradnje s farmaceutskom industrijom. Izravno će pridonijeti stjecanju novih znanja, vještina i međunarodnog iskustva Marine Marinović, olakšavajući pritom povezivanje s vrhunskim znanstvenicima. Sve ovo poslužit će kao temelj za razvoj njene samostalne i međunarodno prepoznatljive karijere, a u konačnici doprinijeti internacionalizaciji Fakulteta i povećanju broja publikacija u znanstvenim časopisima visokog utjecaja.Organizacija-domaćin: Farmaceutski fakultet Sveučilišta u Ljubljani, Slovenija]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15772</id><title_hr><![CDATA[Odlazna mobilnost viših asistenata - Lucija Tudor]]></title_hr><title_en><![CDATA[]]></title_en><user_id>22640</user_id><user_firstLast_name>Lucija Tudor</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBODL</proposal_type><proposal_call>2023-08</proposal_call><code>MOBODL-2023-08-2584</code><acronim><![CDATA[]]></acronim><duration>16.02.2024 - 15.02.2025</duration><status>U tijeku</status><financ_value>48.000,00 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Veliki depresivni poremećaj je čest i složen psihijatrijski poremećaj koji pogađa oko 9% svjetske populacije, ali je njegova zastupljenost u porastu. Etiologija depresije još uvijek je nepoznata te uključuje kompleksnu interakciju genetskih, psihosocijalnih i okolišnih čimbenika, što rezultira heterogenom kliničkom slikom i različitim odgovorom na terapiju. Velik broj oboljelih ne odgovara dobro na trenutno dostupne terapije ili razvija teške nuspojave zbog kojih se liječenje često napušta. Razumijevanje molekularne podloge multifaktorijalnih bolesti poput depresije nužno je za uspostavljanje boljih dijagnostičkih alata, predviđanje tijeka terapije te uspostavljanju odgovarajućeg i personaliziranog pristupa u liječenju ovog poremećaja. Analiza ekspresije regulatornih miRNA molekula iz lako dostupnih bioloških izvora poput ekstracelularnih vezikula može omogućiti identifikaciju novih signalnih puteva promijenjenih u depresiji te mehanizama djelovanja pojedinih terapijskih strategija. Suvremene biomedicinske, analitičke i biostatističke metode, dostupnost podataka iz velikih baza podataka te metode za njihovu analizu omogućuju objedinjenje rezultata iz različitih istraživačkih disciplina i kreiranje jedinstvenog panela biomarkera koji mogu poslužiti kao dijagnostički alat ili potencijalna terapijska meta u liječenju depresije.Organizacija-domaćin: Univerza v Ljubljani Medicinska fakulteta, Slovenija]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15773</id><title_hr><![CDATA[Odlazna mobilnost viših asistenata - Matej Gljušćić]]></title_hr><title_en><![CDATA[]]></title_en><user_id>26057</user_id><user_firstLast_name>Matej Gljušćić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBODL</proposal_type><proposal_call>2023-08</proposal_call><code>MOBODL-2023-08-5758</code><acronim><![CDATA[]]></acronim><duration>24.03.2024 - 23.03.2026</duration><status>U tijeku</status><financ_value>96.000,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, </scie_field_hr><scie_field_en>Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Tehnički fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Engineering]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[S ciljem pružanja održive alternative trenutačno korištenim kompozitima sustavima kod kojih smanjenje mase i multi-funkcionalnost komponenata ima izniman ekonomski i ekološki značaj, ovaj projekt znanstvenog usavršavanja predstavlja implementaciju održivo proizvedene nano-celuloze za poboljšanje mehaničkih svojstava bio-polimera ojačanih prirodnim vlaknima. U prvoj fazi istraživanja, fokus će biti na istraživanju metoda proizvodnje nano-celuloze putem dezintegracije tekstilnog otpada. Analizirat će se način na koji nano-celuloza utječe na mehanička svojstva bio-polimera, provesti će se optimizacija udjela nano-čestica te eksperimentalna validacija dobivenih rezultata. Nastavak istraživanja je usmjeren na kvantifikaciju utjecaja nano-celuloze na kontaktne zone s biljnim, mineralnim i metalnim ojačanjima te analizu nano-celulozom poboljšanih panela prirodnim vlaknima ojačanih bio-kompozita. Provest će se eksperimentalno ispitivanje ponašanja materijala, analizirat će se njihova multifunkcionalna svojstva, otpornost na mehanička oštećenja, te strukturni prijelazi na sintetičke, mineralne i metalne komponente visokih performansi. Dobiveni će rezultati biti integrirani u numeričke modele ponašanja materijala i prilagođeni korištenju u simulacijskim paketima, omogućujući tako optimizaciju konstrukcija i poboljšanje pouzdanosti bio-kompozita u industriji. Osim postizanja znanstvenih ciljeva, ovaj projekt nudi rješenje za smanjenje iscrpljivanja prirodnih resursa, povećanje stupnja recikliranja proizvoda, te promicanje ekonomičnog i ekološkog pristupa smanjenju mase transportnih sustava s ciljem unaprjeđenja efikasnosti prijevoza u skladu s principima održivosti i kružne ekonomije.Organizacija-domaćin: Universidad Carlos III De Madrid, Španjolska]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15786</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Ena Šimunić]]></title_hr><title_en><![CDATA[]]></title_en><user_id>858438</user_id><user_firstLast_name>Ena Šimunić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-2384</code><acronim><![CDATA[]]></acronim><duration>15.01.2024 - 15.03.2024</duration><status>U tijeku</status><financ_value>5.185,00 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Starenje višestaničnih organizama složen je biološki proces povezan s progresivnim propadanjem funkcija većine organa. Mnoge bolesti povezane sa starenjem se kod ljudi različito ispoljavaju ovisno o spolu. Prilikom starenja dolazi do smanjenja mitohondrijske aktivnosti, a narušena mitohondrijska funkcija dovodi do povećanja koncentracije reaktivnih kisikovih vrsta i oksidativnog stresa. Jedan od ključnih proteina za održavanje funkcije mitohondrija je protein Sirtuin 3 (Sirt3), uključen u regulaciju svih važnih mitohondrijskih aktivnosti. S druge strane, adiponektin (APN) je jedan od najzastupljenijih cirkulirajućih hormona koji pospješuje oksidaciju masnih kiselina i glukoze. lako je uloga APN-a, kao i Sirt3, povezana s dugovječnošću, tek u posljednjih par godina su se njihove funkcije počele povezivati. Opći cilj stručnog usavršavanja je proučiti i opisati međusobno djelovanje Sirt3 i APN u različitim uvjetima prehrane miševa prilikom starenja. Obzirom na važnu ulogu APN i Sirt3 u metaboličkim bolestima i bolestima povezanima sa starenjem, pojašnjenje mehanizma njihova međudjelovanja bi značajno doprinijelo njihovom potencijalnom identificiranju kao novih terapijskih ciljeva. Proširivanje i povezivanje uloge Sirt3 s APN bi dalo osnovu za budući razvoj lijekova za metaboličke bolesti i bolesti povezane sa starenjem. Obzirom na sve navedeno, stručno usavršavanje bi doktorandici, osim pružanja međunarodnog iskustva i uspostavljanja suradnje s novim istraživačkim grupama, omogućilo i dobivanje novih spoznaja o ulozi Sirt3 u starenju i bolestima povezanima sa starenjem, te značajno doprinijelo doktorskom radu i pomoglo u razvijanju ideja za buduće projekte. Nadalje, upoznavanje istraživačkih grupa koje se bave sličnom tematikom pruža mogućnosti za poslijedoktorska usavršavanja u inozemstvu, a koja su kasnije uvjet za mogućnost trajnog zapošljavanja na nekim institucijama RH.Organizacija-domaćin: University of Edinburgh, Ujedinjena Kraljevina]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15787</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Natali Neral]]></title_hr><title_en><![CDATA[]]></title_en><user_id>865169</user_id><user_firstLast_name>Natali Neral</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-8257</code><acronim><![CDATA[]]></acronim><duration>01.03.2024 - 12.04.2024</duration><status>U tijeku</status><financ_value>3.655,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Rudarstvo, nafta i geološko inženjerstvo, </scie_field_hr><scie_field_en>Mining, petroleum and geological engineering, </scie_field_en><institution_hr><![CDATA[Institut za arheologiju]]></institution_hr><institution_en><![CDATA[Institute of Archaeology in Zagreb]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Doktorski rad asistentice Natali Neral usmjeren je na istraživanje lončarskih sirovina i tehnologije proizvodnje lončarije iz različitih razdoblja prošlosti na području Republike Hrvatske. Ciljeve istraživanja ostvaruje primjenom različitih analitičkih metoda koje omogućuju rekonstrukciju tehnologije proizvodnje te uvid u vrste i podrijetlo sirovina koje su korištene za izradu keramičkih posuda.Asistentica će kroz znanstveno-stručno usavršavanje na University College London (UCL) steći iskustvo u primjeni novih analitičkih metoda (p-XRF i SEM-EDS) na arheološkoj keramici koje se u Hrvatskoj vrlo rijetko koriste, posebice za analize arheološkog materijala. Usavršavanjem će specijalizirati pripremu uzoraka, rukovanje instrumentima te rad u programima za interpretaciju rezultata u jednom od najbolje opremljenih laboratorija Europe. Prikupljeni rezultati poboljšati će kvalitetu dosadašnjeg istraživanja te omogućiti razmatranje tehnoloških izbora i društvenih procesa zajednica koje su na prostoru Hrvatske obitavale kroz različita razdoblja prošlosti. Suradnja sa stručnjakom za analizu keramike, profesorom P. Quinn-om, asistentici će omogućiti stjecanje iskustva u obradi podataka novih analitičkih metoda te kroz diseminaciju rezultata koja će proizaći iz suradnje doprinijeti poboljšanju istraživačke karijere i prepoznavanju hrvatskih znanstvenika na međunarodnoj razini. Znanja stečena usavršavanjem omogućiti će nove suradnje sa znanstveno-istraživačkim institucijama i laboratorijima na području Hrvatske koji takvu opremu posjeduju ali je ne primjenjuju na arheološkom materijalu.Organizacija-domaćin: University College London, Ujedinjena Kraljevina]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15789</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6126</user_id><user_firstLast_name>Marina Cvjetko Bubalo</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-6047</code><acronim><![CDATA[]]></acronim><duration>30.09.2024 - 29.09.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Biotehnologija, </scie_field_hr><scie_field_en>Biotechnology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Food Technology and Biotechnology]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15792</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>12549</user_id><user_firstLast_name>Dijana Oreški</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-1298</code><acronim><![CDATA[]]></acronim><duration>10.01.2025 - 09.01.2031</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Informacijske znanosti, </scie_field_hr><scie_field_en>Information sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet organizacije i informatike]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Organization and Informatics]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15793</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Antonela Moretić]]></title_hr><title_en><![CDATA[]]></title_en><user_id>865235</user_id><user_firstLast_name>Antonela Moretić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-3700</code><acronim><![CDATA[]]></acronim><duration>01.02.2024 - 10.05.2024</duration><status>U tijeku</status><financ_value>8.500,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Građevinarstvo, </scie_field_hr><scie_field_en>Civil engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Građevinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Civil Engineering]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Potres u ožujku 2020. u Zagrebu prouzrokovao je značajnu materijalnu štetu, posebno u gradskoj jezgri, čija je kulturološka vrijednost nepobitna. Fokus istraživanja je na donjogradskim tradicionalnim zidanim građevinama organiziranim u blokovsku konfiguraciju. Više je parametara koji impliciraju na njihov povišen rizik. Zagrebačka regija karakterizirana je visokim hazardom, velik broj korisnika građevina implicira na povišenu izloženost, a postojeći konstruktivni sustavi nemaju dostatnu otpornost na horizontalna djelovanja, tj. karakterizirani su visokom oštetljivošću. Redukciju potresnog rizika najjednostavnije je ostvariti redukcijom oštetljivosti. Potresna oštetljivost procjenjuje se empirijskim, analitičkim, hibridnim metodama ili pristupima baziranima na inženjerskoj procjeni. Osim što su postojeće empirijske metode relevantne za određena područja, nedostatak jasnih smjernica za analizu utjecaja bloka dovodi do poteškoća u procjeni njihovog odziva jedinica bloka. Potrebno je razviti pouzdanu makroseizmičku i analitičku metodu za ocjenu oštetljivosti, prilagođenu hrvatskom kontekstu. Izrada numeričkih modela i nelinearna analiza pojedinih konfiguracija gradnje omogućit će usporedbu odziva i procjenu utjecaja blokova. Novi parametri bit će definirani na temelju ovih modela i validirani pomoću stvarnih podataka nakon potresa. Razvoj ovakve metode ima potencijal značajno smanjiti potresni rizik, posebno u područjima poput Zagreba gdje su tradicionalne građevine u blokovima važan dio kulturne baštine.Organizacija-domaćin: Technical University of Catalonia, Španjolska]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15796</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Karlo Ožić]]></title_hr><title_en><![CDATA[]]></title_en><user_id>861469</user_id><user_firstLast_name>Karlo Ožić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-3843</code><acronim><![CDATA[]]></acronim><duration>14.01.2024 - 03.03.2024</duration><status>U tijeku</status><financ_value>4.250,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Građevinarstvo, </scie_field_hr><scie_field_en>Civil engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Građevinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Civil Engineering]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Nakon nedavnih potresa u Zagrebu, Petrinji i okolici, prepoznata je hitna potreba za brzim ocjenama stanja građevina. Iz tog razloga, nastala je ideja o brzoj metodi procjene potresne oštetljivosti neomeđenih zidanih građevina kao tipu građevine koji je pretrpio najviše oštećenja u nedavnim potresima. Za primjenu dostupnih metode procjene oštetljivosti na slučaj zidanih zgrada u Zagrebu potrebna je prilagodba parametara i njihova kalibracija. Svakako, kombiniranjem specifičnih parametara, ova nova metoda omogućuje efikasnu preliminarnu procjenu. Razvoj nove metode uključuje stvaranje baze podataka zgrada, stvaranje taksonomija zidanih građevina prema njihovim karakteristikama te odabir reprezentativnih građevina za numeričke simulacije. Nakon analize osjetljivosti parametara kojima ćemo točnije utvrditi utjecaj raznih parametara na ponašanje građevine pri djelovanju potresa, metoda će biti validirana usporedbom s nelinearnim simulacijama i stvarnim oštećenjima iz potresa. U konačnici, ova metoda će pružati korisne informacije o ponašanju zgrada tijekom potresa te može biti od pomoći inženjerima za brze procjene građevina nakon potresa, ali i za procjene rizika gradova i većih područja.Organizacija-domaćin: Spanish National Research Council, Španjolska]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15798</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>13219</user_id><user_firstLast_name>Mijo Nikolić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-8014</code><acronim><![CDATA[]]></acronim><duration>17.09.2024 - 16.09.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Temeljne tehničke znanosti, </scie_field_hr><scie_field_en>Basic engineering sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu Fakultet građevinarstva, arhitekture i geodezije]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Civil Engineering, Architecture and Geodesy]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15799</id><title_hr><![CDATA[Raznolikost i interakcije mikobioma raka kore kestena]]></title_hr><title_en><![CDATA[Diversity and interactions of the chestnut bark canker mycobiome]]></title_en><user_id>2506</user_id><user_firstLast_name>Marin Ježić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IPCH</proposal_type><proposal_call>2023-10</proposal_call><code>IPCH-2023-10-1986</code><acronim><![CDATA[DiveInBiome]]></acronim><duration>15.11.2024 - 14.11.2028</duration><status>U tijeku</status><financ_value>190.288,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>17770, 761, 1532, 2565, 1456, 975, 757, 27583, 868747, </team_members_id><team_members_names><![CDATA[Lucija Nuskern, Mirna  Ćurković Perica, Ljiljana Krstin, Rosemary Vuković, Zorana Katanić, Marilena Idžojtić, Igor Poljak, Antonio Vidaković, Dino Davosir, ]]></team_members_names><keywords_hr><![CDATA[rak kestena, sekvenciranje visoke protočnosti, interakcije mikrobioma, oksidacijski stres, virom]]></keywords_hr><keywords_en><![CDATA[Chestnut blight, high throughput sequencing, microbe interaction, oxidative stress, virome]]></keywords_en><summary_hr><![CDATA[Za potpuno razumijevanje biljnih bolesti, osim domaćina i patogena, treba uzeti u obzir i druge abiotičke i biotičke čimbenike koji mogu utjecati na njihovu interakciju. Gljiva Cryphonectria parasitica, uzročnik raka kestenove kore jedan je od najpoznatijih uzročnika bolesti drveća u svijetu. Inficira osjetljive vrste kestena uzrokujući smrtonosne lezije (rak kore). Nakon unosa i inicijalnog epidemijskog širenja, ova bolest je u Europi poprimila blaži tijek zbog pojave virusa – CHV1, koji smanjuje virulentnost zaražene gljive, čineći rakove nesmrtonosnima, što je osnova za biokontrolu bolesti.Stoga nam je cilj istražiti mikobiom i virom unutar raka kore kao i specifične interakcije gljiva-gljiva i gljiva-virus. Budući da niti jedna studija do danas nije ispitala druge čimbenike osim CHV1 koji bi mogli dovesti do zacjeljivanja raka, drugi virusi potencijalno prisutni u C. parasitica mogli bi biti odgovorni za dodatni hipovirulentni učinak, poboljšavajući učinkovitost biokontrole, dok bi druge gljive unutar raka mogle djelovati kao konkurencija C. parasitica.Studija se sastoji od dva radna paketa, koje vode projektni partneri. U WP1 ćemo okarakterizirati raznolikost mikobioma i viroma u rakovima kore provodeći terensko uzorkovanje prirodnih i umjetno iniciranih rakova korištenjem klasičnih i najsuvremenijih HTS metoda za karakterizaciju gljivičnih i virusnih zajednica. U WP2 ćemo istražiti interakcije između gljive C. parasitica, drugih gljiva koje obitavaju u kori kao i mikovirusa. To će se učiniti uzgojem na istoj podlozi odabranih sojeva C. parasitica i drugih vrsta otkrivenih u WP1 te procjenom ishoda ove interakcije.Naš će projekt značajno povećati opće znanje o mikobiomu i viromu kore pitomog kestena, pružajući nove informacije o njegovoj raznolikosti, promjenama nakon infekcije bakterijom C. parasitica i njegovom konačnom doprinosu biokontroli raka kore kestena.]]></summary_hr><summary_en><![CDATA[To fully understand a plant disease, beyond the host and the pathogen, other abiotic and biotic factors that may influence their interactions should be considered. The fungus Cryphonectria parasitica, the causal agent of chestnut blight is one of the most famous pathogens of trees worldwide. It infects susceptible chestnut species causing lethal bark lesions (cankers). After its introduction and an initial epidemic spread, chestnut blight in Europe took a milder course due to the emergence of a virus – CHV1, that reduces virulence of the infected fungus making the cankers no longer lethal, providing the basis for biocontrol of the disease. Thus, we aim to investigate both mycobiome and virome within chestnut blight cankers and specific fungus-fungus and fungus-virus interactions. As no study to date has tested other factors beyond the CHV1 that could lead to healing of cankers, other viruses potentially present in C. parasitica may be responsible for additional hypovirulent effect, improving the biocontrol efficiency, while other fungi could act as competitors against C. parasitica as well.The study consists of two working packages, led by a different project partner. In WP1, we will characterize the diversity of the mycobiome and the virome in bark cankers by conducting field sampling of natural and artificially initiated cankers using both classical and state-of-the-art HTS methods to characterize fungal and viral communities. In WP2, we will investigate interactions between the fungus C. parasitica, other bark-inhabiting fungi, and mycoviruses. This will be done by co-culturing selected strains of C. parasitica and other fungal species detected in WP1 and assessing the outcome of this interaction.Our project will significantly increase general knowledge on the sweet chestnut bark mycobiome and virome, providing novel information about its diversity, changes following an infection by C. parasitica and its eventual contribution to the biocontrol of chestnut blight.]]></summary_en></project><project>
<id>15801</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Hrvoje Lukačić]]></title_hr><title_en><![CDATA[]]></title_en><user_id>867492</user_id><user_firstLast_name>Hrvoje Lukačić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-2375</code><acronim><![CDATA[]]></acronim><duration>09.02.2024 - 12.04.2024</duration><status>U tijeku</status><financ_value>5.440,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Rudarstvo, nafta i geološko inženjerstvo, </scie_field_hr><scie_field_en>Mining, petroleum and geological engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Rudarsko-geološko-naftni fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mining, Geology and Petroleum Engineering]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Procesi odronjavanja predstavljaju problem u gotovo svim dijelovima svijeta jer se pojavljuju iznenada te uzrokuju ekonomske i socijalne gubitke. Bez poznavanja mehanizma nastanka odrona, procesa koji slijede nakon njegove pojave te prostorne distribucije područja izvorišta odrona nije moguće racionalno i odgovorno upravljanje prostorom. U posljednjih dvadeset godina cesta je primjena daljinskih metoda istraživanja u okviru izrade karata podložnosti na odronjavanje. Prednost daljinskih metoda prikupljanja podataka primjenom fotogrametrijskih te LIDAR metoda je da omogućavaju izradu 3D oblaka točaka vrlo visoke rezolucije (< 1 cm) za vizualizaciju terena te provedbu inženjersko-geološkog kartiranja i zoniranja. Rezultati regionalne procjene podložnosti na odronjavanje pokazali su da je 8.8% teritorija Republike Hrvatske visoko podložno na mogućnost pojave odrona, s većinom zona u primorskom dijelu Republike Hrvatske. Navedena informacija ukazuje na potrebu stvaranja znanstveno-stručnog okvira unutar kojeg ce biti definirana optimalna metodologija za provedbu daljinskih metoda istraživanja, metodologija za provedbu inženjersko-geološkog kartiranja na 3D oblacima točaka te izrađen program otvorenog koda u programskom jeziku MATLAB za provedbu procjene podložnosti na odronjavanje u krupnom mjerilu. suradnji asistenta Hrvoja Lukačića a s Mentorom-domaćinom profesorom Michelom Jaboyedoffom te Organizacijom-domaćinom Sveučilištem u Lausanni istražit će se utjecaj različitih metoda izrade 3D oblaka točaka (terestrička fotogrametrija, fotogrametrija dronom i terestričko lasersko skeniranje) na kvalitetu 3D oblaka točaka te će se na izrađenim modelima provesti inženjersko-geološko kartiranje. Glavni cilj stručnog usavršavanja bit će razvoj nove metodologije za procjenu podložnosti na odronjavanje u krupnom mjerilu integracijom prostornih kinematičkih analiza i proračuna volumetrijskog broja pukotina. Rezultat će biti predstavljen u obliku programa otvorenog koda razvijenog u programskom jeziku MATLAB za procjenu podložnosti na odronjavanje postavljen u GITHUB otvoreni repozitorij i dostupan široj znanstvenoj i stručnoj zajednici.Organizacija-domaćin: University of Lausanne, Švicarska]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15802</id><title_hr><![CDATA[Odlazna mobilnost asistenata - David Bojanić]]></title_hr><title_en><![CDATA[]]></title_en><user_id>861754</user_id><user_firstLast_name>David Bojanić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-6710</code><acronim><![CDATA[]]></acronim><duration>01.02.2024 - 04.07.2024</duration><status>U tijeku</status><financ_value>13.175,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Usavršavanje asistenta bavi se problemom prilagodbe statističkog modela ljudskoga tijela na dani 3D parcijalni sken osobe kako bi se ostvario primarni cilj doktorskog istraživanja asistenta, te same istraživačke grupe u kojoj asistent djeluje. Primarni cilj je omogućiti praktično i efikasno modeliranje oblika ljudskoga tijela za širu javnost. Takav cilj podrazumijeva robusnost metode na dane ulazne podatke (parcijalni 3D skenovi) te što nižu zahtjevnost metode na danim ulaznim podatcima (metoda ne smije imati posebne zahtjeve nad osobom koja biva skenirana, kao što su npr. uska odjeća ili određena poza subjekta). Zbog široke primjene znanja o ljudskom obliku (modna industrija, sportska industrija, medicina, ergonomija, itd.) takav bi istraživački iskorak imao širi doprinos od same znanstvene zajednice i pružio veću i lakšu primjenu znanja o ljudskom tijelu.Organizacija-domaćin: Université Grenoble Alpes, Francuska]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15804</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>199</user_id><user_firstLast_name>Josip Stipčević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-1415</code><acronim><![CDATA[]]></acronim><duration>22.10.2024 - 21.10.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Geofizika, </scie_field_hr><scie_field_en>Geophysics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15806</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1485</user_id><user_firstLast_name>Ivan Štajduhar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-3131</code><acronim><![CDATA[]]></acronim><duration>03.10.2024 - 02.10.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Tehnički fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Engineering]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15807</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Dora Belec]]></title_hr><title_en><![CDATA[]]></title_en><user_id>867496</user_id><user_firstLast_name>Dora Belec</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-3637</code><acronim><![CDATA[]]></acronim><duration>19.02.2024 - 20.05.2024</duration><status>U tijeku</status><financ_value>7.820,00 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Farmacija, </scie_field_hr><scie_field_en>Pharmaceutical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Farmaceutsko-biokemijski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Pharmacy and Biochemistry]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Pojavnost potencijalno neprikladnih lijekova u osoba starije životne dobi iznosi i do 56,3 %, a na području Europe 35 %. Također upotreba potencijalno neprikladnih lijekova među starijim pacijentima postala je sve raširenija u posljednja dva desetljeća. U Republici Hrvatskoj pojavnost je i dvostruko veća u odnosu na prosjek Europe te ona iznosi oko 60 %. Korištenje navedenih lijekova može imati ozbiljne posljedice, kako za samog pacijenta, tako i za zdravstveni sustav u cjelini. Neke od tih posljedica uključuju nuspojave lijekova i njihovo liječenje, smanjenje kvalitete života, prekomjerno uzimanje lijekova, loše pridržavanje propisane terapije te povećane troškove za zdravstveni sustav. S obzirom na brzo starenje populacije u mnogim zemljama, problem potencijalno neprikladnog propisivanja postaje sve važniji. Razumijevanje i pronalaženje rješenja za taj problem može doprinijeti boljoj zdravstvenoj skrbi, smanjenju troškova i poboljšanju kvalitete života starijih osoba. Kao moguće rješenje nameće se depreskripcija terapije. Depreskripcija terapije je proces koji podrazumijeva postupno i pažljivo ukidanje ili smanjenje doze lijekova koji se smatraju neprikladnima za određenog pacijenta. Ovaj proces se obavlja pod strogim nadzorom medicinskog stručnjaka, najčešće liječnika, u suradnji s pacijentom i multidisciplinarnim timom zdravstvenih stručnjaka koji su uključeni u njegovo liječenje. Depreskripcija je nov postupak koji nije uvriježen u svakodnevnoj kliničkoj praksi većine zdravstvenih sustava. Za uvođenje novih postupaka u kliničku praksu potrebno je provesti istraživanja koja će obuhvatiti različite postupke, metodologije i strategije te ispitati učinak novog postupka na ishode liječenja kao i potrebe, prepreke i mogućnosti uvođenja u svakodnevnu kliničku praksu. Mobilnost doktoranda i suradnja sa Sveučilištem u Corku, koje ima iskustvo u istraživanju uvođenja depreskripcije u domove za starije, omogućit će usvajanje novih znanja i vještina potrebnih za provođenje prvog takvog istraživanja u Republici Hrvatskoj. Očekivane koristi uvođenja depreskripcije mogle bi biti višestruke i dovesti do smanjenja nuspojava lijekova i rizika od interakcija, povećanja kvalitete života pacijenata, smanjenja troškova terapije i općenito bolje prilagodbe terapije individualnim potrebama pacijenta.Organizacija-domaćin: University College Cork, Irska]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15808</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Ivona Baniček]]></title_hr><title_en><![CDATA[]]></title_en><user_id>865001</user_id><user_firstLast_name>Ivona Baniček</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-8512</code><acronim><![CDATA[]]></acronim><duration>01.03.2024 - 01.06.2024</duration><status>U tijeku</status><financ_value>7.905,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Geologija, </scie_field_hr><scie_field_en>Geology, </scie_field_en><institution_hr><![CDATA[Hrvatski geološki institut]]></institution_hr><institution_en><![CDATA[Croatian Geological Survey]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Asistentica Ivona Baniček izučiti će, i pridonijeti daljnjem razvoju, metoda analize drevne peludne i okolišne DNK na Globe institutu Sveučilišta u Kopenhagenu. Dato usavršavanje će unaprijediti znanje i vještine relevantne za njezino doktorsko istraživanje koje je fokusirano na određivanje utjecaja burnih klimatskih uvjeta od posljednjeg ledenog doba do danas na prilagodbu vegetacije istočne obale Jadrana. Komparacijom rezultata palinoloških analiza (istraživanje peludi i spora) i rezultata metoda drevne peludne DNK i okolišne DNK dobiti će se znatno preglednija slika dinamičnog okoliša prošlosti. Istraživanje promjena osjetljivih obalnih ekosustava usred oscilirajuće klime je korisno u kontekstu pripreme adaptacijskih strategija za buduće scenarije. Područje Kvarnera i Dalmacije ima osobit značaj i u arheološkom smislu jer je predstavljalo utočište precima modernog čovjeka koji se nastanio na ovim područjima tražeći sklonište od surovih uvjeta središnje Europe potkraj zadnjeg ledenog doba. Ilustrirati krajolik naših predaka pomaže u predviđanjima okolišnih uvjeta tijekom aktualnih klimatskih promjena. Sva ta pitanja interesiraju i geologe i biologe, a ovo istraživanje bi trebalo objediniti obje perspektive na razvoj klime i okoliša. Asistentici će usavršavanje na Globe institutu omogućiti korištenje najsuvremenije opreme te rad u čistim laboratorijima što će ju profilirati u suverenog istraživača paleoekologa.Organizacija-domaćin: University of Kopenhagen, Danska]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15809</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Lucija Fiket]]></title_hr><title_en><![CDATA[]]></title_en><user_id>858333</user_id><user_firstLast_name>Lucija Fiket</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-5991</code><acronim><![CDATA[]]></acronim><duration>30.01.2024 - 02.06.2024</duration><status>U tijeku</status><financ_value>10.625,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Kemijsko inženjerstvo, </scie_field_hr><scie_field_en>Chemical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet kemijskog inženjerstva i tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Chemical Engineering and Technology]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Vodljivi polimeri pripadaju u posebnu vrstu polimera koji, za razliku od većine polimernih materijala s kojima se susrećemo u svakodnevnom životu, imaju sposobnost provođenja električne struje. Zbog svoje stabilnosti, električne provodnosti i male mase njihova primjena u industriji elektronike se sve više koristi i istražuje. Potencijalno područje primjene je i u proizvodnji savitljive fleksibilne elektronike, ali za tu primjenu im nedostaje svojstvo istezljivosti jer su to prirodno kruti materijali. U ovom istraživanju koristit će se vodljivi polimer poli(3,4-etilendioksitiofen) (PEDOT) koji će se kemijski modificirati cijepljenjem bočnih lanaca mekanog polimera poli(akrilat-uretana) (PAU) i stvaranjem kompozitnog materijala koji kombinira takav modificirani PEDOT termoplastične elastomere. Ovaj postupak omogućava kontrolirano poboljšanje mehaničkih svojstava PEDOT-a uz zadržavanje električne provodnosti. Također če se istražiti sposobnost materijala da samozacijeli nakon oštećenja te će se testirati primjena materijala u izradi biološkog senzora za mjerenje otkucaja srca, Planirano usavršavanje će dati dodanu vrijednost doktorskom radu doktorandice Lucije Fiket, a istraživanje ima potencijal stjecanja novih znanja o materijalima za nosivu, fleksibilnu elektroniku. Kroz primjenu ovih materijala očekuje poticanje inovacija u domaćoj elektroničkoj industriji i podrška ekonomskom rastu. Također, samozacjeljivost materijala može smanjiti otpad elektroničkih uređaja, doprinoseći održivoj tehnologiji.Organizacija-domaćin: University of Auckland, Novi Zeland]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15810</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Ana-Marija Lulić]]></title_hr><title_en><![CDATA[]]></title_en><user_id>858373</user_id><user_firstLast_name>Ana-Marija Lulić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-3514</code><acronim><![CDATA[]]></acronim><duration>01.02.2024 - 02.05.2024</duration><status>U tijeku</status><financ_value>7.820,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut za medicinska istraživanja i medicinu rada]]></institution_hr><institution_en><![CDATA[Institute for Medical Research and Occupational Health]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Metabolizam je skup kemijskih reakcija u kojima sudjeluje veliki broj enzima i molekula, a njegova glavna uloga je dobivanje energije iz hrane za normalno funkcioniranje organizma, ali i sinteza i razgradnja biomolekula, tj. lipida, ugljikohidrata, aminokiselina i nukleinskih kiselina, koje su neophodne za izgradnju staničnih organela i membrana zbog čega je potrebna izuzetno stroga regulacija. Bolesti kao što su pretilost, dijabetes tipa 2, kardiovaskularne bolesti i razvoj tumora vrlo često se povezuju s poremećajima u metabolizmu. Lipaze su porodica enzima koje imaju važnu ulogu u razgradnji i prijenosu različitih lipidnih vrsta — kolesterola, fosfolipida, triacilglicerola i brojnih drugih. Glavni fokus predloženog usavršavanja je biokemijska i biofizikalna karakterizacija jedne lipaze pod imenom PNPLA7. Ova lipaza razgrađuje lizofosfolipide, podvrstu fosfolipida, koji imaju važnu ulogu u izgradnji staničnih membrana, ali imaju i ulogu signalnih molekula u procesima regulacije metabolizma glukoze i masnih kiselina, upalnih procesa i stanične smrti. Istraživanja provedena na PNPLA7 su malobrojna, njegova kristalna struktura nije riješena, a fiziološka uloga nepoznata. Međutim, nedavna istraživanja su pokazala da PNPLA7 ima važnu ulogu u metabolizmu i da je reguliran metaboličkim signalima kao što su inzulin i glukoza. Cilj predloženog usavršavanja je primjenom genetičkih, biokemijskih i računalnih metoda, ispitati specifičnost ovog enzima prema svojim supstratima i potencijalnim inhibitorima i povezati odnos strukture i funkcije ovog proteina kako bi dobili uvid u njegovu fiziološku ulogu. Budući da istraživačka grupa dr. sc. Monike Oberer ima višegodišnje iskustvo u radu s lipazama, predloženi boravak u njenom laboratoriju omogućit će usavršavanje u metodama koje se primjenjuju u radu s lipazama i karakterizaciji njihove strukture koje trenutno nisu dostupne na Institutu za medicinska istraživanja i medicinu rada. Isto tako, predloženo usavršavanje otvorit će put prema suradnji i s drugim istraživačkim skupinama iz ovog područja istraživanja u Europi, ali i iz ostatka svijeta.Organizacija-domaćin: Graz Universität, Austrija]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15811</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Anamarija Pulitika]]></title_hr><title_en><![CDATA[]]></title_en><user_id>865030</user_id><user_firstLast_name>Anamarija Pulitika</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-8942</code><acronim><![CDATA[]]></acronim><duration>05.02.2024 - 30.06.2024</duration><status>U tijeku</status><financ_value>12.495,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Kemijsko inženjerstvo, </scie_field_hr><scie_field_en>Chemical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet kemijskog inženjerstva i tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Chemical Engineering and Technology]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Mikroplastika se danas smatra novim onečišćivalom koje izaziva zabrinutost zbog velike količine, postojanosti i rasprostranjenosti, kao i zbog potencijalnog štetnog učinka na okoliš na zdravlje ljudi. Adsorpcija organskih onečišćivala na mikroplastiku u vodi dodatan je razlog za zabrinutost s obzirom da mikroplastika može prenositi organska onečišćivala kroz okoliš, ali i unutar organizma te ih pri određenim uvjetima i otpustiti sa svoje površine u procesu desorpcije. Adsorpcija i desorpcija organskih onečišćivala utječu na ponašanje mikroplastike u vodi kao na njenu ukupnu toksičnost. Kako bi se pravilno procijenili potencijalni rizici od mikroplastike, potrebno je bolje razumijevanje adsorpcijskog mehanizma i prirode interakcija između mikroplastike i organskih onečiščivala kao i utjecaja vanjskih faktora poput temperature, ukupne količine otopljenih soli drugih otopljenih organskih tvari na adsorpcijski kapacitet. Eksperimentalni rezultati do danas pokazuju da su interakcije između mikroplastike i organskih onečišćivala u vodi uglavnom slabe fizikalne interakcije, no ne daju nam uvid u interakcije na molekulskoj razini. Kako bismo bolje razumjeli i opisali mehanizam adsorpcije, interakcije i utjecaj vanjskih čimbenika na adsorpciju, u ovom istraživanju koristimo računalne metode molekularne dinamike. Metode molekularne dinamike simuliraju ponašanje sustava mikroplastika/organsko onečišćivalo u vremenu iz čega možemo dobiti korisne informacije o afinitetu mikroplastike za razna organska onečišćivala, kompetitivnosti organskih onečišćivala s molekulama vode, mehanizmu adsorpcije te utjecaju molekula otapala, prisutnih iona drugih organskih tvari na adsorpcijski kapacitet. Predloženo istraživanje doprinijet će razumijevanju mehanizma adsorpcije organskih onečišćivala na mikroplastiku te utjecaja vodenog medija na adsorpciju na molekularnoj razini, Također, podatci o adsorpcijskim kapacitetima interakcijama između mikroplastike i organskih onečišćivala mogu poslužiti za stvaranje predikcijskih modela ponašanja mikroplastike i organskih onečišćivala u ovisnosti o svojstvima vodenog medija te za bolje razumijevanje štetnog učinka mikroplastike na okoliš.Organizacija-domaćin: Université de Pau et des Pays de LAdour, Francuska]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15812</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Ena Pezić]]></title_hr><title_en><![CDATA[]]></title_en><user_id>865234</user_id><user_firstLast_name>Ena Pezić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-4191</code><acronim><![CDATA[]]></acronim><duration>17.02.2024 - 16.05.2024</duration><status>U tijeku</status><financ_value>7.650,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Svrha ovog studijskog boravka je napraviti novi pomak prema primjeni razvijenih prevlaka, kako detaljna karakterizacija ponašanja radikala nastalih izlaganjem materijala ionizirajućem zračenju otvara dva potencijalna smjera. S jedne strane, prisutnost dugoživih radikala treba biti dobro poznata jer prilikom izlaganja materijala novom okolišu postoji mogućnost njihove interakcije sa novom sredinom. U tom slučaju trebaju se razviti preventivni postupci koji će onesposobiti negativne učinke ovakvih interakcija. S druge strane, prisutnost dugoživih radikala otvara nove mogućnosti primjene prevlaka. Naime, radikali mogu biti ciljano iskorišteni, pošto mogu poslužiti kao inicijatori u reakcijama graftiranja. U tom slučaju se otvara mogućnost primjene različitih molekula na prevlake, čime se dodatno otvaraju mogućnosti ciljane primjene razvijenih prevlaka. U svakom slučaju rezultati predloženog studijskog boravka su iznimno važni za buduća istraživanja primjene razvijenih prevlaka.Organizacija-domaćin: National Agency for New Technologies, Energy and Sustainable Economic Development, Italija]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15813</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Karla Ostojić]]></title_hr><title_en><![CDATA[]]></title_en><user_id>861499</user_id><user_firstLast_name>Karla Ostojić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-5757</code><acronim><![CDATA[]]></acronim><duration>15.01.2024 - 21.03.2024</duration><status>U tijeku</status><financ_value>5.695,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Cilj našeg istraživačkog projekta je razviti hidrogelove temeljene na želatinu i hijaluronskoj kiselini koji će se koristiti 3D model osteosarkoma, agresivnog tumora kostiju. Hidrogelove ćemo sintetizirati i temeljito karakterizirati kako bismo odabrali one koji su najstabilniji i pokazuju najbolju interakciju sa stanicama. 3D modeli predstavljaju bolji model od 2D kulture jer više nalikuju prirodnom okruženju tumorskih stanica. Na 3D modelu ćemo ispitati djelovanje kemoterapeutika na staničnoj liniji osteosarkoma, a nakon povratka u Hrvatsku, i na uzorcima matičnih stanica sarkoma iz pacijenata.Organizacija-domaćin: Universitat Politecnica de Valencia, Španjolska]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15814</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Magdalena Grgić]]></title_hr><title_en><![CDATA[]]></title_en><user_id>858357</user_id><user_firstLast_name>Magdalena Grgić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-7682</code><acronim><![CDATA[]]></acronim><duration>05.02.2024 - 06.04.2024</duration><status>U tijeku</status><financ_value>5.270,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Školjkaši iz roda Congeria jedini su podzemni školjkaši Staroga svijeta. Ovi tercijarni relikti se već milijunima godina naizgled savršeno prilagođavaju promjenjivom okolišu oko sebe. Razlozi za njihov evolucijski uspjeh i dalje su gotovo potpuno nepoznati. Jedan od važnih alata u takvim istraživanjima je genom. Nedavno sekvenciranim genomom vrsta Congeria kusceri se svrstala u mali broj špiljskih životinja u svijetu kod kojih će odgovore o adaptacijama na špilje biti moguće tražiti izravno u njihovoj genomskoj sekvenci. Stoga će predloženo usavršavanje iz područja komparativne genomike na Sveučilištu u Trstu pomoći u odgovaranju na pitanja kako i zašto ovaj školjkaš može preživjeti surove uvjete života u špiljama poput konstantnog mraka i male količine hrane. Za vrstu C. kusceri ovo je iznimno bitno jer osim što će nam dati nove vrijedne znanstvene spoznaje, omogućit će i uvid u potencijalne prijetnje preživljenju ove kritično ugrožene vrste hrvatskog podzemlja.Organizacija-domaćin: Universita degli studi di Trieste, Italija]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15815</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Josipa Maslač]]></title_hr><title_en><![CDATA[]]></title_en><user_id>867490</user_id><user_firstLast_name>Josipa Maslač</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-7201</code><acronim><![CDATA[]]></acronim><duration>01.02.2024 - 24.05.2024</duration><status>U tijeku</status><financ_value>9.690,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Geologija, </scie_field_hr><scie_field_en>Geology, </scie_field_en><institution_hr><![CDATA[Hrvatski geološki institut]]></institution_hr><institution_en><![CDATA[Croatian Geological Survey]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Ovo znanstveno istraživanje usmjereno je na pružanje geoloških osnova bitnih za razumijevanje seizmičkog rizika u Hrvatskoj, posebno na širem području Vukomeričkih gorica i Žumberačko-Samoborskog gorja, gdje seizmički rizik predstavlja značajnu opasnost za lokalne zajednice, infrastrukturu i okoliš. Do sada su provedena ograničena istraživanja aktivnih rasjeda koji predstavljaju seizmičku opasnost u prethodno spomenutim područjima, iako je poznata njihova seizmička aktivnost. Ovim projektom nastoji se odgovoriti na ključna pitanja o aktivnim rasjedima u području - njihova pozicija, karakteristike i seizmogeni potencijal, koristeći tektonsko-geomorfološki pristup uz kasniju primjenu plitkih geofizičkih istraživanja. Ključni ciljevi obuhvaćaju identifikaciju aktivnih rasjeda šireg područja Vukomeričkih gorica i Žumberačko-Samoborskog gorja, njihove geometrijske i kinematske karakteristike te procjenu sposobnosti generiranja potresa u budućnosti. Asistentica Josipa Maslač proći će specijaliziranu obuku kako bi stekla potrebne vještine i znanje za ovo istraživanje. Ona uključuje tektonsko-geomorfološko kartiranje i analizu, upotrebu geofizičkih metoda poput georadara i elektrostatske tomografije te suradnju s međunarodnim stručnjacima kako bi stekla znanje i iskustvo. Istraživanje će rezultirati identifikacijom aktivnih rasjeda, geomorfološkim kartama tragova pružanja rasjeda s označenim pomaknutim geomorfološkim markerima, procjenama pomaka po rasjedima i novim spoznajama o seizmičkoj aktivnosti povezanom s geodinamskim procesima u cijeloj regiji.Ovo istraživanje ima kako lokalnu, tako i nacionalnu važnost: na lokalnoj razini poboljšava razumijevanje seizmičkog rizika i opasnosti za zajednice u istraživanom području, dok na nacionalnoj razini unapređuje razumijevanje seizmičkog rizika u Hrvatskoj, usklađujući je sa zemljama koje imaju napredno znanje u ovom području. Takvo će istraživanje potaknuti suradnju s međunarodnim istraživačima i ojačati položaj Hrvatske u prekograničnim geološkim studijama doprinoseći naporima regije za stvaranje jedinstvene seizmotektonske baze. Rezultati ovog istraživanja bit će objavljeni u znanstvenim radovima i prezentirani na konferencijama, doprinoseći globalnim saznanja o aktivnim rasjedima i seizmičkoj opasnosti mediteranske regije. Ovaj projekt predstavlja ključni korak prema jačanju seizmičke otpornosti Hrvatske i razumijevanju geoloških procesa koji su ključni za buduću sigurnost i razvoj zemlje.Organizacija-domaćin: Geološki zavod Slovenije]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15816</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5002</user_id><user_firstLast_name>Danijela Bakarić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-7492</code><acronim><![CDATA[]]></acronim><duration>14.01.2025 - 13.01.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15818</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Lea Pašalić]]></title_hr><title_en><![CDATA[]]></title_en><user_id>855428</user_id><user_firstLast_name>Lea Pašalić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-3104</code><acronim><![CDATA[]]></acronim><duration>25.02.2024 - 25.05.2024</duration><status>U tijeku</status><financ_value>7.735,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Dostava lijekova unutar stanica predstavlja ključni izazov u suvremenoj medicini. Budući da su stanice okružene membranama koje djeluju kao barijere, štiteći unutrašnjost od stranih tvari, tradicionalni načini dostave lijekova, poput oralnog unosa ili intravenozne primjene, često su neučinkoviti i mogu uzrokovati nuspojave štetne za zdravlje. Budući da postoji velika potreba za razvojem novih načina „pametne“ dostave lijekova, kao alternativa tradicionalnim načinima dostave lijekova nameću se peptidi koji sa ili bez određenog tereta prodiru u stanicu (engl. cell penetrating peptides, CPPs). CPP-ovi su kratke sekvence koje ne sadrže više od 20-ak aminokiselina, uglavnom kationskih i hidrofobnih, te predstavljaju potencijalnu revolucionarnu tehnologiju u biomedicini. Njihova sposobnost prolaska kroz membranu sa ili bez tereta bez narušavanja membranske strukture otvara vrata za inovativne terapeutske pristupe. Buduća istraživanja u ovom području mogla bi proširiti mogućnosti terapijskih opcija i pridonijeti medicinskim dostignućima u borbi protiv raznih bolesti. lako se posljednjih desetljeća provode intenzivna istraživanja na membranama, dublje razumijevanje njihove strukturne organizacije i međusobne interakcije sastavnih dijelova na molekulskoj razini kao i interakcija lipidnih membrana s peptidima i dalje su nedovoljno razjašnjeni. Mehanizam prodiranja CPP-ova ovisi o sastavu peptida, molekulskom teretu koji prenosi, ali i o sastavu membrane, no pojedini koraci u samom mehanizmu ulaska CPP-ova u stanicu ostaju nerazjašnjeni. U sklopu predloženoga projekta istražit će se utjecaj peptida koji u sebi sadrže aminokiseline arginin/lizin na lipidne membrane koje po sastavu oponašaju stanice eukariota odnosno prokariota, a pritom će se koristiti kalorimetrijske, spektroskopske i mikroskopske tehnike. Osim što će se istražiti razlika u adsorpciji oligopeptida R9 i K9 na molekulskoj razini na različitim modelnim mebranama različitog oblika i veličine (kalorimetrija, UV-Vis i FTIR spektroskopija) na matičnoj instituciji, okarakterizirat će se i utjecaj fluorescentnih proba kojima se obilježavaju peptidi i lipidi na njihovu međusobnu interakciju (fluorescencijska spektroskopija i mikroskopija) u sklopu predloženog projekta. Eksperimentalni rezultati dobiveni na J. Heyrovsky Institute of Physical Chemistry u Pragu, pod vodstvom prof. Sachla upotpunit će se eksperimentalnim rezultatima dobivenima na matičnoj instituciji, te računskim simulacijama u suradnji s dr. sc. Barbarom Pem (IRB), kao i u suradnji s računskim grupama u Pragu (dr. sc. Mario Vazdar, University of Chemistry and Technology, Prag).Organizacija-domaćin: Czech Academy of Sciences, J. Heyrovsky Institute of Physical Chemistry, Češka Republika]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15821</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Lucija Stepinac]]></title_hr><title_en><![CDATA[]]></title_en><user_id>867499</user_id><user_firstLast_name>Lucija Stepinac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-4242</code><acronim><![CDATA[]]></acronim><duration>01.02.2024 - 31.03.2024</duration><status>U tijeku</status><financ_value>5.100,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Temeljne tehničke znanosti, </scie_field_hr><scie_field_en>Basic engineering sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Arhitektonski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Architecture]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[3D printanje omogućuje arhitektima veću slobodu u oblikovanju i izradi složenih elemenata, otvarajući nove mogućnosti za inovativne dizajne. Građevinske tvrtke i izvođači mogu imati koristi od implementacije 3D printanja u svoje procese izgradnje. 3D printanje nosivih konstrukcija može poboljšati produktivnost, smanjiti troškove i ubrzati vrijeme izgradnje. U okviru ovog istraživanja promatrat će se 3D printane ploče izrazito složene ispunske geometrije za pješačke mostove izrađene od suvremenih visokokvalitetnih materijala. Cilj istraživanja je topološka optimizacija presjeka, tj. smanjenje mase uz zadržavanje iste nosivosti ploča. Dodatna vrijednost topološke optimizacije je izrazito složena geometrija nosača koja je estetski vrlo zanimljiva. Projektni rezultati mogu biti od interesa za sveučilišta, istraživačke institucije i obrazovne ustanove koje se bave arhitekturom, građevinarstvom i naprednim tehnologijama. Ova ciljna skupina može pružiti dodatno istraživanje i razvoj u području 3D printanih nosivih konstrukcija.Organizacija-domaćin: École polytechnique fédérale de Lausanne, Švicarska]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15822</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Domagoj Jelić]]></title_hr><title_en><![CDATA[]]></title_en><user_id>867480</user_id><user_firstLast_name>Domagoj Jelić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-2114</code><acronim><![CDATA[]]></acronim><duration>13.04.2024 - 19.05.2024</duration><status>U tijeku</status><financ_value>3.145,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Science]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Kvalitativna teorija dinamičkih sustava odavno je prisutna, ali i sve popularnija kao predmet istraživanja u matematici. U sklopu ove teorije istražuje se evolucija sustava nekih stanja (koje u matematici zovemo točkama) kroz vrijeme. Naime, česti su problemi u prirodi koji su, zbog svoje kompliciranosti, kvantitativno nerješivi poput problema gibanja i međudjelovanja svemirskih tijela, izrada meteoroloških modela, promatranja evolucije populacija određenih organizama. Ovakvim problemima stoga se pristupa kvalitativno, kroz teoriju dinamičkih sustava, kako bi se pronašla zadovoljavajuća rješenja. Često nas, osim „individualne“ dinamike, zanima i „kolektivna“ dinamika, odnosno evolucija određenih skupova stanja kroz vrijeme. Tijekom ovog znanstveno-istraživačkog usavršavanja asistent planira dodatnim istraživanjem upravo ovakve, kolektivne dinamike, doći do rezultata po pitanju njene kaotičnosti, odnosno nepredvidivosti, njezine stabilnosti i općenito odnosa evolucije stanja u baznom i induciranom, kolektivnom sustavu. Organizacija-domaćin: Charles University Prague, Faculty of Mathematics and Physics]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15827</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>13100</user_id><user_firstLast_name>Miranda Sertić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-1086</code><acronim><![CDATA[]]></acronim><duration>04.11.2024 - 03.11.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Farmacija, </scie_field_hr><scie_field_en>Pharmaceutical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Farmaceutsko-biokemijski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Pharmacy and Biochemistry]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15828</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>43</user_id><user_firstLast_name>Igor Jurak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-7304</code><acronim><![CDATA[]]></acronim><duration>23.10.2024 - 22.10.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Interdisciplinarno područje znanosti</scie_area_hr><scie_area_en>Interdisciplinary scientific area</scie_area_en><scie_field_hr>Biotehnologija u biomedicini, </scie_field_hr><scie_field_en>Biotechnology in Biomedicine, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Fakultet biotehnologije i razvoja lijekova]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Biotechnology and Drug Development]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15835</id><title_hr><![CDATA[Uloga metabolizma kinurenina u imunološki posredovanim neurorazvojnim poremećajima nakon citomegalovirusne infekcije]]></title_hr><title_en><![CDATA[The role of kynurenine metabolism in immune-mediated neurodevelopmental pathology after cytomegalovirus infection]]></title_en><user_id>11106</user_id><user_firstLast_name>Stipan Jonjić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IPCH</proposal_type><proposal_call>2023-10</proposal_call><code>IPCH-2023-10-1746</code><acronim><![CDATA[KynuVirBrain]]></acronim><duration>01.10.2024 - 30.09.2028</duration><status>U tijeku</status><financ_value>198.245,00 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Medicine]]></institution_en><team_members_id>4958, 22696, 865130, 25391, 20528, </team_members_id><team_members_names><![CDATA[Astrid Krmpotić, Tina Ružić, Jelena Materljan, Valentina Hribljan, Ivan Bubić, ]]></team_members_names><keywords_hr><![CDATA[kongenitalna citomegalovirusna infekcija, neuroinflamacija, kinureninski metabolički put, neuro- imunodulacija, NK stanice, mikroglija, razvoj mozga]]></keywords_hr><keywords_en><![CDATA[congenital CMV infection, neuroinflammation, kynurenine metabolites,  neuro-immunomodulation, NK cells, microglia,neurodevelopment ]]></keywords_en><summary_hr><![CDATA[Prirođena infekcija citomegalovirusom (CMV) najčešća je intrauterina virusna infekcija. Približno jedna trećina simptomatske novorođenčadi razvija širok spektar poremećaja u razvoju CNS-a. Molekularni mehanizmi koji dovode do oštećenja središnjeg živčanog sustava i posljedičnih neuroloških poremećaja nakon CMV infekcije slabo su razjašnjeni. Infekcija novookoćenih miševa mišjim CMV-om (MCMV) u mnogome je slična patogenezi CMV u mozgu tijekom prirpđene infekcije u ljudi. Naša otkrića su pokazala da IFN-? kojeg luče NK/ILC1 stanice posreduju aktivaciju mikroglije i uzrokuje poremećaj u razvoju malog mozga u novookoćenih miševa zaraženih MCMV-om. Katabolizam triptofana u kinureninskom putu stvara kinolinsku kiselinu koja se koristi za de novo sintezu NAD. Kinurenin i njegovi metaboliti također su imunološke i neuromodulatorne molekule koje vežu glutamatergičke receptore, G-protein spojene receptore i aril ugljikovodične receptore (Ahr). Transkripcija prvog enzima u kinureninskom putu, Ido1, posredovana je s IFN-?, što ukazuje da je aktivacija kinureninskog puta izravno povezana s upalom. Međutim, uloga puta kinurenina u neurorazvojnoj patologiji tijekom CMV infekcije nije istražena. U ovom projektu planiramo istražiti utjecaj IFN-? koje luče NK stanice na aktivaciju kinureninskog puta u mikrogliji u mozgu zaraženom MCMV-om. Također ćemo odrediti ulogu aktivacije kinureninskog puta u modulaciji ranog postnatalnog cerebelarnog razvoja i u nastanku neurofunkcionalnih nedostataka. Mehanistički gledano, ispitat ćemo učinke nedostatka triptofana i metabolita kinureninskog puta na sazrijevanje zrnatih neurona malog mozga te na funkciju NK stanica. Također, istražit ćemo ulogu kinurenin-Ahr signalizacije u zrnatim neuronima tijekom cerebelarnog razvoja nakon MCMV infekcije. Na kraju, ispitat ćemo ulogu IFN-?–kinurenin u kontekstu prirođene CMV infekcije u ljudi.]]></summary_hr><summary_en><![CDATA[Congenital cytomegalovirus (CMV) infection is the most common intrauterine viral infection in the world. Approximately one-third of symptomatic infants, and to a lesser extent asymptomatic infants, develop long-term CNS manifestations. The molecular mechanisms driving CNS damage and subsequent neurologic deficits after CMV infection are ill-understood. Mouse CMV (MCMV) infection of newborn mice phenocopies many facets of CMV pathogenesis in the brain of congenitally infected infants. Our recent findings demonstrated that IFN-? derived from NK/ILC1 cells mediated microglial activation and delayed cerebellar development in MCMV-infected newborn mice. Tryptophan catabolism along the kynurenine pathway generates quinolinic acid, which is used for de novo NAD synthesis. Kynurenine and its metabolites are also immune- and neuro-modulatory molecules that bind glutamatergic receptors, G-protein coupled receptors, and aryl hydrocarbon receptor (Ahr). Transcription of the first enzyme in the kynurenine pathway, Ido1, is mediated by IFN-? signalling, demonstrating that kynurenine pathway activation is directly linked to inflammation. However, potential role of Kynurenine pathway in linking inflammation to neurodevelopmental pathology during CMV infection has not been explored. In this proposal, we plan to explore the impact of NK cell-derived IFN-? on kynurenine pathway induction in microglia from MCMV infected brain. We will also determine the role of kynurenine pathway activation in modulating early postnatal cerebellar development and in driving neurofunctional deficits. Mechanistically, we will examine effects of tryptophan depletion and kynurenine pathway metabolites on cerebellar granule neuron maturation and on NK cell function. Likewise, we will explore the role of kynurenine-Ahr signaling in granule neurons during cerebellar development following MCMV infection. Lastly, we will interrogate the IFN-?–kynurenine axis in the context of congenital human CMV infection.]]></summary_en></project><project>
<id>15836</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>54</user_id><user_firstLast_name>Oliver Vugrek</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-6414</code><acronim><![CDATA[]]></acronim><duration>06.03.2025 - 05.03.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15837</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>2829</user_id><user_firstLast_name>Zrinka Ljubešić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-7968</code><acronim><![CDATA[]]></acronim><duration>06.11.2024 - 05.11.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15838</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>867515</user_id><user_firstLast_name>Jelena Bujan</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-7322</code><acronim><![CDATA[]]></acronim><duration>17.10.2024 - 16.10.2029</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15841</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>12479</user_id><user_firstLast_name>Katarina Vukojević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-8265</code><acronim><![CDATA[]]></acronim><duration>01.10.2024 - 30.09.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Split School of Medicine]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15843</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>13333</user_id><user_firstLast_name>Goran Krajačić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-1949</code><acronim><![CDATA[]]></acronim><duration>01.06.2025 - 31.05.2031</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, </scie_field_hr><scie_field_en>Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15845</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>21451</user_id><user_firstLast_name>Darko Vončina</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-9090</code><acronim><![CDATA[]]></acronim><duration>11.10.2024 - 10.10.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Agronomski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Agriculture]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15846</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3713</user_id><user_firstLast_name>Anamaria Brozović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-7710</code><acronim><![CDATA[]]></acronim><duration>10.01.2025 - 09.01.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15847</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>24476</user_id><user_firstLast_name>Ivan Lukačević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-8821</code><acronim><![CDATA[]]></acronim><duration>01.11.2024 - 31.10.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Građevinarstvo, </scie_field_hr><scie_field_en>Civil engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Građevinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Civil Engineering]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15849</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3927</user_id><user_firstLast_name>Dubravka Vitali Čepo</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-6543</code><acronim><![CDATA[]]></acronim><duration>15.10.2024 - 14.10.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Farmacija, </scie_field_hr><scie_field_en>Pharmaceutical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Farmaceutsko-biokemijski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Pharmacy and Biochemistry]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15852</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>776</user_id><user_firstLast_name>Ana Marušić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-6600</code><acronim><![CDATA[]]></acronim><duration>01.10.2024 - 30.09.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Javno zdravstvo i zdravstvena zaštita, </scie_field_hr><scie_field_en>Public health and health services, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Split School of Medicine]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15855</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>77</user_id><user_firstLast_name>Stjepan Špalj</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-7708</code><acronim><![CDATA[]]></acronim><duration>22.10.2024 - 22.10.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Dentalna medicina, </scie_field_hr><scie_field_en>Dental medicine, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Fakultet dentalne medicine]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Dental Medicine]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15856</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>114</user_id><user_firstLast_name>Marina Šantić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-7240</code><acronim><![CDATA[]]></acronim><duration>21.10.2024 - 20.10.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Medicine]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15858</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>12661</user_id><user_firstLast_name>Anamarija Rogina</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-8686</code><acronim><![CDATA[]]></acronim><duration>23.09.2024 - 22.09.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Kemijsko inženjerstvo, </scie_field_hr><scie_field_en>Chemical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet kemijskog inženjerstva i tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Chemical Engineering and Technology]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15859</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5657</user_id><user_firstLast_name>Krešimir Salamon</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-3031</code><acronim><![CDATA[]]></acronim><duration>18.03.2026 - 17.03.2031</duration><status>U tijeku</status><financ_value>60,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15860</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>305</user_id><user_firstLast_name>Danijel Grahovac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-3763</code><acronim><![CDATA[]]></acronim><duration>01.10.2024 - 30.09.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Fakultet primijenjene matematike i informatike]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, School of Applied Mathematics and Informatics]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15861</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>984</user_id><user_firstLast_name>Hrvoje Kušić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-9580</code><acronim><![CDATA[]]></acronim><duration>01.10.2024 - 30.09.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Kemijsko inženjerstvo, </scie_field_hr><scie_field_en>Chemical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet kemijskog inženjerstva i tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Chemical Engineering and Technology]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15864</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1107</user_id><user_firstLast_name>Maja Herak Bosnar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-8602</code><acronim><![CDATA[]]></acronim><duration>07.10.2024 - 06.10.2029</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15866</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>21407</user_id><user_firstLast_name>Jonatan Lerga</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-3157</code><acronim><![CDATA[]]></acronim><duration>14.07.2025 - 13.07.2031</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Tehnički fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Engineering]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15868</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6886</user_id><user_firstLast_name>Dario Bojanjac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-4663</code><acronim><![CDATA[]]></acronim><duration>12.09.2024 - 11.09.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15869</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>620</user_id><user_firstLast_name>Ana Palčić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-3932</code><acronim><![CDATA[]]></acronim><duration>25.03.2025 - 24.03.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15872</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6152</user_id><user_firstLast_name>Mateja Dumbović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-2818</code><acronim><![CDATA[]]></acronim><duration>05.11.2025 - 05.11.2031</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Geodetski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Geodesy]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15875</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5188</user_id><user_firstLast_name>Ivan Senta</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-7882</code><acronim><![CDATA[]]></acronim><duration>08.10.2024 - 07.10.2029</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Interdisciplinarne prirodne znanosti, </scie_field_hr><scie_field_en>Interdisciplinary natural sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15876</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>76</user_id><user_firstLast_name>Silvana Raić-Malić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-9186</code><acronim><![CDATA[]]></acronim><duration>23.09.2024 - 22.09.2023</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet kemijskog inženjerstva i tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Chemical Engineering and Technology]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15877</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>11207</user_id><user_firstLast_name>Iva Tolić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-8766</code><acronim><![CDATA[]]></acronim><duration>14.03.2025 - 13.03.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15883</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>20147</user_id><user_firstLast_name>Ljiljana Šerić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-5328</code><acronim><![CDATA[]]></acronim><duration>11.11.2024 - 10.11.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Fakultet elektrotehnike, strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Electrical Engineering, Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15886</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>29004</user_id><user_firstLast_name>Željka Sanader Maršić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-2713</code><acronim><![CDATA[]]></acronim><duration>01.01.2025 - 31.12.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Science]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15895</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>244</user_id><user_firstLast_name>Tajana Begović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-2255</code><acronim><![CDATA[]]></acronim><duration>25.11.2024 - 24.11.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15898</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>22664</user_id><user_firstLast_name>Marko Radulović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-7798</code><acronim><![CDATA[]]></acronim><duration>10.10.2024 - 09.10.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15903</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4852</user_id><user_firstLast_name>Adela Štimac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-9372</code><acronim><![CDATA[]]></acronim><duration>01.10.2024 - 30.09.2024</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu]]></institution_hr><institution_en><![CDATA[University of Zagreb]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15904</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>11303</user_id><user_firstLast_name>Biljana Balen</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-6343</code><acronim><![CDATA[]]></acronim><duration>15.10.2024 - 14.10.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15907</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4661</user_id><user_firstLast_name>Šime Ukić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-2351</code><acronim><![CDATA[]]></acronim><duration>14.10.2024 - 13.10.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet kemijskog inženjerstva i tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Chemical Engineering and Technology]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15908</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1330</user_id><user_firstLast_name>Maja Repajić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-8307</code><acronim><![CDATA[]]></acronim><duration>01.10.2024 - 30.09.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Prehrambena tehnologija, </scie_field_hr><scie_field_en>Food technology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Food Technology and Biotechnology]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15910</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4503</user_id><user_firstLast_name>Ivana Ivančić Baće</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-9630</code><acronim><![CDATA[]]></acronim><duration>09.10.2024 - 08.10.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15912</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>22771</user_id><user_firstLast_name>Nicholas James Bradshaw</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-6409</code><acronim><![CDATA[]]></acronim><duration>11.10.2024 - 10.10.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Interdisciplinarno područje znanosti</scie_area_hr><scie_area_en>Interdisciplinary scientific area</scie_area_en><scie_field_hr>Biotehnologija u biomedicini, </scie_field_hr><scie_field_en>Biotechnology in Biomedicine, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Fakultet biotehnologije i razvoja lijekova]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Biotechnology and Drug Development]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15913</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>21151</user_id><user_firstLast_name>Stefano (Antonio) Mezzasalma</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-8420</code><acronim><![CDATA[]]></acronim><duration>13.02.2025 - 12.02.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15914</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4828</user_id><user_firstLast_name>Silva Katušić Hećimović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-6286</code><acronim><![CDATA[]]></acronim><duration>19.11.2024 - 18.11.2029</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15916</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5765</user_id><user_firstLast_name>Ida Delač</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-4241</code><acronim><![CDATA[]]></acronim><duration>20.11.2024 - 19.11.2024</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut za fiziku]]></institution_hr><institution_en><![CDATA[Institute of Physics in Zagreb]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15919</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1081</user_id><user_firstLast_name>Mario Habek</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-5543</code><acronim><![CDATA[]]></acronim><duration>28.10.2024 - 27.10.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Clinical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15920</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>890</user_id><user_firstLast_name>Neven Grbac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-1542</code><acronim><![CDATA[]]></acronim><duration>01.10.2024 - 30.09.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište Jurja Dobrile u Puli]]></institution_hr><institution_en><![CDATA[Juraj Dobrila University of Pula]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15923</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>7421</user_id><user_firstLast_name>Silvija  Krajter Ostoić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-4492</code><acronim><![CDATA[]]></acronim><duration>01.04.2025 - 31.03.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Šumarstvo, </scie_field_hr><scie_field_en>Forestry, </scie_field_en><institution_hr><![CDATA[Hrvatski šumarski institut]]></institution_hr><institution_en><![CDATA[Croatian Forest Research Institute]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15924</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>12928</user_id><user_firstLast_name>Alan Jović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-1384</code><acronim><![CDATA[]]></acronim><duration>16.09.2024 - 15.09.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15926</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>19976</user_id><user_firstLast_name>Mia Kurek</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-6678</code><acronim><![CDATA[]]></acronim><duration>30.09.2024 - 29.09.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Prehrambena tehnologija, </scie_field_hr><scie_field_en>Food technology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Food Technology and Biotechnology]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15927</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>74</user_id><user_firstLast_name>Sandi  Orlić </user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-5459</code><acronim><![CDATA[]]></acronim><duration>08.10.2024 - 07.10.2029</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15933</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3406</user_id><user_firstLast_name>Nina Štirmer</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-9413</code><acronim><![CDATA[]]></acronim><duration>10.03.2025 - 09.03.2031</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Temeljne tehničke znanosti, </scie_field_hr><scie_field_en>Basic engineering sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Građevinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Civil Engineering]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15934</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>2787</user_id><user_firstLast_name>Damir Pajić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-1073</code><acronim><![CDATA[]]></acronim><duration>15.10.2024 - 14.10.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15935</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>13782</user_id><user_firstLast_name>Marko Kralj</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-6493</code><acronim><![CDATA[]]></acronim><duration>01.10.2024 - 30.09.2029</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut za fiziku]]></institution_hr><institution_en><![CDATA[Institute of Physics in Zagreb]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15936</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>18946</user_id><user_firstLast_name>Ana Bielen</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-4481</code><acronim><![CDATA[]]></acronim><duration>30.09.2024 - 29.09.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Interdisciplinarne prirodne znanosti, </scie_field_hr><scie_field_en>Interdisciplinary natural sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Food Technology and Biotechnology]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15938</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6256</user_id><user_firstLast_name>Nataša Jovanov Milošević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-7312</code><acronim><![CDATA[]]></acronim><duration>15.10.2024 - 14.10.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15939</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>26609</user_id><user_firstLast_name>Jasmina Lukinac Čačić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-4301</code><acronim><![CDATA[]]></acronim><duration>04.11.2024 - 03.11.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Prehrambena tehnologija, </scie_field_hr><scie_field_en>Food technology, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Prehrambeno-tehnološki fakultet]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Food Technology]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15940</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5655</user_id><user_firstLast_name>MARTINA ĐODAN</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-4199</code><acronim><![CDATA[]]></acronim><duration>01.04.2025 - 31.03.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Biotehnologija, </scie_field_hr><scie_field_en>Biotechnology, </scie_field_en><institution_hr><![CDATA[Hrvatski šumarski institut]]></institution_hr><institution_en><![CDATA[Croatian Forest Research Institute]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15941</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>7082</user_id><user_firstLast_name>Bojan Polić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-8636</code><acronim><![CDATA[]]></acronim><duration>07.10.2024 - 06.10.2024</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Medicine]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15942</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6592</user_id><user_firstLast_name>Ana Sović Kržić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-5844</code><acronim><![CDATA[]]></acronim><duration>10.09.2024 - 09.09.2030</duration><status>U tijeku</status><financ_value>0,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15945</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>865529</user_id><user_firstLast_name>Ana Čikoš</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-7553</code><acronim><![CDATA[]]></acronim><duration>14.10.2024 - 13.10.2029</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15946</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>20202</user_id><user_firstLast_name>Davor Dolar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-8063</code><acronim><![CDATA[]]></acronim><duration>01.10.2024 - 30.09.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Kemijsko inženjerstvo, </scie_field_hr><scie_field_en>Chemical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet kemijskog inženjerstva i tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Chemical Engineering and Technology]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15947</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5324</user_id><user_firstLast_name>Ines Sviličić Petrić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-6977</code><acronim><![CDATA[]]></acronim><duration>10.10.2024 - 09.10.2029</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Interdisciplinarne prirodne znanosti, </scie_field_hr><scie_field_en>Interdisciplinary natural sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15948</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1362</user_id><user_firstLast_name>Maja Mičetić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-5138</code><acronim><![CDATA[]]></acronim><duration>01.09.2025 - 31.08.2030</duration><status>U tijeku</status><financ_value>60,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15952</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>865864</user_id><user_firstLast_name>Fausto Miguel Pascoal Ferreira</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-6296</code><acronim><![CDATA[]]></acronim><duration>09.09.2024 - 08.09.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15954</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5393</user_id><user_firstLast_name>Sven Lončarić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-8777</code><acronim><![CDATA[]]></acronim><duration>01.11.2024 - 31.10.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15956</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6982</user_id><user_firstLast_name>Damir Seršić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-2147</code><acronim><![CDATA[]]></acronim><duration>06.09.2024 - 05.09.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15957</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>24626</user_id><user_firstLast_name>Daniela Kalafatovic</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-8638</code><acronim><![CDATA[]]></acronim><duration>11.10.2024 - 10.10.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Interdisciplinarno područje znanosti</scie_area_hr><scie_area_en>Interdisciplinary scientific area</scie_area_en><scie_field_hr>Biotehnologija u biomedicini, </scie_field_hr><scie_field_en>Biotechnology in Biomedicine, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Tehnički fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Engineering]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15960</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>24947</user_id><user_firstLast_name>Ivor Lončarić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-2165</code><acronim><![CDATA[]]></acronim><duration>01.11.2024 - 31.10.2029</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15961</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>352</user_id><user_firstLast_name>Zvjezdana Findrik Blazevic</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-7599</code><acronim><![CDATA[]]></acronim><duration>14.10.2024 - 13.10.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Kemijsko inženjerstvo, </scie_field_hr><scie_field_en>Chemical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet kemijskog inženjerstva i tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Chemical Engineering and Technology]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15963</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>19686</user_id><user_firstLast_name>Davor Davidović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-9165</code><acronim><![CDATA[]]></acronim><duration>11.11.2024 - 10.11.2029</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15964</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>19584</user_id><user_firstLast_name>Maja Sabol</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-5842</code><acronim><![CDATA[]]></acronim><duration>04.11.2024 - 03.11.2029</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15965</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>63</user_id><user_firstLast_name>Vesna Boraska Perica</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-6819</code><acronim><![CDATA[]]></acronim><duration>01.10.2024 - 30.09.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Split School of Medicine]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15968</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>558</user_id><user_firstLast_name>Matija Gredičak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-3099</code><acronim><![CDATA[]]></acronim><duration>20.12.2024 - 19.12.2029</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15969</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>363</user_id><user_firstLast_name>Martina Sudar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-2869</code><acronim><![CDATA[]]></acronim><duration>14.10.2024 - 13.10.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Kemijsko inženjerstvo, </scie_field_hr><scie_field_en>Chemical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet kemijskog inženjerstva i tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Chemical Engineering and Technology]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15970</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>12766</user_id><user_firstLast_name>Nikola Cindro</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-4616</code><acronim><![CDATA[]]></acronim><duration>09.01.2025 - 08.01.2031</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15971</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3075</user_id><user_firstLast_name>Danka Grčević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-4220</code><acronim><![CDATA[]]></acronim><duration>15.10.2024 - 14.10.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15973</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>309</user_id><user_firstLast_name>Marina Tišma</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-1846</code><acronim><![CDATA[]]></acronim><duration>24.10.2024 - 23.10.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Biotehnologija, </scie_field_hr><scie_field_en>Biotechnology, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Prehrambeno-tehnološki fakultet]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Food Technology]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15975</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>2954</user_id><user_firstLast_name>Nikica Šprem</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-7683</code><acronim><![CDATA[]]></acronim><duration>10.11.2025 - 09.11.2031</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Biotehnologija, </scie_field_hr><scie_field_en>Biotechnology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Agronomski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Agriculture]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15977</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>280</user_id><user_firstLast_name>Krunoslav Užarević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-2322</code><acronim><![CDATA[]]></acronim><duration>24.02.2025 - 23.02.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15979</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4217</user_id><user_firstLast_name>Nataša Bauer</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-7493</code><acronim><![CDATA[]]></acronim><duration>16.10.2024 - 15.10.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15982</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>15915</user_id><user_firstLast_name>Vjekoslav Tomaić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-6533</code><acronim><![CDATA[]]></acronim><duration>10.10.2024 - 09.10.2029</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15985</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4806</user_id><user_firstLast_name>Ignacija Vlašić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-3935</code><acronim><![CDATA[]]></acronim><duration>09.10.2024 - 08.10.2029</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15986</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>2689</user_id><user_firstLast_name>Dunja Šamec</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-5666</code><acronim><![CDATA[]]></acronim><duration>25.10.2024 - 24.10.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Prehrambena tehnologija, </scie_field_hr><scie_field_en>Food technology, </scie_field_en><institution_hr><![CDATA[Sveučilište Sjever]]></institution_hr><institution_en><![CDATA[University North]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15988</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>69</user_id><user_firstLast_name>Rozi Andretić Waldowski</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-2442</code><acronim><![CDATA[]]></acronim><duration>11.10.2024 - 10.10.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Interdisciplinarno područje znanosti</scie_area_hr><scie_area_en>Interdisciplinary scientific area</scie_area_en><scie_field_hr>Biotehnologija u biomedicini, </scie_field_hr><scie_field_en>Biotechnology in Biomedicine, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci]]></institution_hr><institution_en><![CDATA[University of Rijeka]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15992</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4578</user_id><user_firstLast_name>Đurđica Ačkar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-5493</code><acronim><![CDATA[]]></acronim><duration>14.10.2024 - 13.10.2024</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Prehrambena tehnologija, </scie_field_hr><scie_field_en>Food technology, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Prehrambeno-tehnološki fakultet]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Food Technology]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15996</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3325</user_id><user_firstLast_name>Goran Vukelić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-8023</code><acronim><![CDATA[]]></acronim><duration>19.11.2024 - 18.11.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Temeljne tehničke znanosti, </scie_field_hr><scie_field_en>Basic engineering sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Pomorski fakultet ]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Maritime Studies]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15997</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>252</user_id><user_firstLast_name>Nikola Vladimir</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-4092</code><acronim><![CDATA[]]></acronim><duration>01.11.2025 - 31.10.2031</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Brodogradnja, </scie_field_hr><scie_field_en>Naval architecture, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>15999</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>21420</user_id><user_firstLast_name>Matko Orsag</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-8251</code><acronim><![CDATA[]]></acronim><duration>01.10.2024 - 30.09.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16002</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5584</user_id><user_firstLast_name>Ivan Ćatipović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-5718</code><acronim><![CDATA[]]></acronim><duration>10.01.2025 - 09.01.2031</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Brodogradnja, </scie_field_hr><scie_field_en>Naval architecture, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16005</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4677</user_id><user_firstLast_name>Dora Višnjić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-9321</code><acronim><![CDATA[]]></acronim><duration>15.10.2024 - 14.10.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16007</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6211</user_id><user_firstLast_name>Jan Šnajder</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-1392</code><acronim><![CDATA[]]></acronim><duration>01.01.2025 - 31.12.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16009</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>2885</user_id><user_firstLast_name>Sibila Borojević Šoštarić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-4427</code><acronim><![CDATA[]]></acronim><duration>01.10.2024 - 30.09.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Geologija, </scie_field_hr><scie_field_en>Geology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Rudarsko-geološko-naftni fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mining, Geology and Petroleum Engineering]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16010</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>875</user_id><user_firstLast_name>Leandra Vranjes Markic</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-5811</code><acronim><![CDATA[]]></acronim><duration>09.10.2024 - 08.10.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Science]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16011</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>62</user_id><user_firstLast_name>Ivana Novak Nakir</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-8890</code><acronim><![CDATA[]]></acronim><duration>15.10.2024 - 14.10.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Split School of Medicine]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16014</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6497</user_id><user_firstLast_name>Igor Kuzle</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-6502</code><acronim><![CDATA[]]></acronim><duration>07.10.2024 - 06.10.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16015</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>11174</user_id><user_firstLast_name>Olga Gornik Kljaić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-8399</code><acronim><![CDATA[]]></acronim><duration>11.11.2024 - 10.11.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Farmacija, </scie_field_hr><scie_field_en>Pharmaceutical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Farmaceutsko-biokemijski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Pharmacy and Biochemistry]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16016</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4656</user_id><user_firstLast_name>Ivana Biljan</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-4161</code><acronim><![CDATA[]]></acronim><duration>04.11.2024 - 03.11.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16017</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>12487</user_id><user_firstLast_name>Maja Šegvic Klarić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-2348</code><acronim><![CDATA[]]></acronim><duration>11.11.2024 - 10.11.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Farmacija, </scie_field_hr><scie_field_en>Pharmaceutical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Farmaceutsko-biokemijski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Pharmacy and Biochemistry]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16021</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1191</user_id><user_firstLast_name>Ana Knezović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-3354</code><acronim><![CDATA[]]></acronim><duration>15.10.2024 - 14.10.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16025</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>7049</user_id><user_firstLast_name>Bruno Zelić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-3890</code><acronim><![CDATA[]]></acronim><duration>23.09.2024 - 22.09.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Kemijsko inženjerstvo, </scie_field_hr><scie_field_en>Chemical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet kemijskog inženjerstva i tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Chemical Engineering and Technology]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16026</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>11142</user_id><user_firstLast_name>Maja  Telišman Prtenjak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-2541</code><acronim><![CDATA[]]></acronim><duration>01.11.2024 - 31.10.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Geofizika, </scie_field_hr><scie_field_en>Geophysics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16027</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>349</user_id><user_firstLast_name>Krešimir Burazin</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-6282</code><acronim><![CDATA[]]></acronim><duration>01.10.2024 - 30.09.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Fakultet primijenjene matematike i informatike]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, School of Applied Mathematics and Informatics]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16030</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>20684</user_id><user_firstLast_name>Gabrijel Ondrašek</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-6191</code><acronim><![CDATA[]]></acronim><duration>21.11.2024 - 20.11.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Agronomski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Agriculture]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16037</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3970</user_id><user_firstLast_name>Marija Cerjak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-3469</code><acronim><![CDATA[]]></acronim><duration>01.10.2025 - 30.09.2031</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Interdisciplinarne biotehničke znanosti, </scie_field_hr><scie_field_en>Interdisciplinary biotechnical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Agronomski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Agriculture]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16040</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>12403</user_id><user_firstLast_name>Igor Pasković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-1951</code><acronim><![CDATA[]]></acronim><duration>07.10.2024 - 06.10.2029</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Institut za poljoprivredu i turizam]]></institution_hr><institution_en><![CDATA[Institute of Agriculture and Tourism in Poreč]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16041</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>20413</user_id><user_firstLast_name>Marko Černe</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-7343</code><acronim><![CDATA[]]></acronim><duration>01.09.2025 - 31.08.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Institut za poljoprivredu i turizam]]></institution_hr><institution_en><![CDATA[Institute of Agriculture and Tourism in Poreč]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16043</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Marta Marija Bilić]]></title_hr><title_en><![CDATA[]]></title_en><user_id>867576</user_id><user_firstLast_name>Marta Marija Bilić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-7017</code><acronim><![CDATA[]]></acronim><duration>06.05.2024 - 10.06.2024</duration><status>U tijeku</status><financ_value>3.060,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Građevinarstvo, </scie_field_hr><scie_field_en>Civil engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Građevinski fakultet u Rijeci]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Civil Engineering]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Kada se poplave događaju istovremeno zbog visoke morske razine i zbog visokih protoka rijeke, štete i posljedice za društvo i okoliš postaju puno ozbiljnije. Takve događaje nazivamo složenim poplavama. Ovaj problem je posebno izražen u priobalnim rijekama Republike Hrvatske, te se istražuje sklopu projekta „Složene poplave u priobalnoj Hrvatskoj u sadašnjoj i budućoj klimi” (IP-2022-10-7598).Za potrebe procjene opasnosti od složenih poplava, neophodni su precizni i opsežni podaci o protocima rijeka i o visokim razinama mora. Za razliku od podataka o protocima rijeka koji su lako dostupni i opsežni, podaci o morskim razinama su ograničeni dužinom niza podataka i malim brojem mjernih postaja. Za doktorsko istraživanje asistentice, podaci o morskim razinama nužni su duž cijele obale Republike Hrvatske, a ne samo na pojedinim lokacijama mjernih postaja.Korištenjem matematičkih modela, moguće je dobiti nizove podataka o morskim razinama duž obale, neovisno o lokacijama mjernih postaja. Jedan od naprednijih modela razvijen je od strane Instituta za znanosti o moru (CNR-ISMAR) u Veneciji, koji je ujedno i domaćin ovog usavršavanja. Korištenjem takvog pristupa za dobivanje preciznih i pouzdanih podataka o morskim razinama značajno će se unaprijediti točnost procjene opasnosti od složenih poplava u Republici Hrvatskoj.Da bi se provjerila pouzdanost prethodno spomenutog matematičkog modela, rezultati se kontinuirano uspoređuju s izmjerenim podacima morskih razina na talijanskoj obali Jadranskog mora. U sklopu ovog usavršavanja, provest će se usporedba s mjerenjima morskih razina Jadranskog mora i na hrvatskoj obali. Na taj način će se unaprijediti vjerodostojnost rezultata matematičkog modela te će se omogućiti šira primjena dobivenih rezultata.U Republici Hrvatskoj još nisu provedene analize složenih poplava, stoga će dobiveni pouzdani podaci o morskim razinama značajno poboljšati buduće procjene složenih poplava u Republici Hrvatskoj.Rezultati usavršavanja biti će prezentirani na međunarodnim konferencijama i objavljeni u znanstvenim časopisima, te predstavljeni javnosti na Građevinskom fakultetu u Rijeci. Uz to, očekuje se jačanje postojeće suradnje između Sveučilišta u Rijeci i Instituta za znanosti o moru (CNR-ISMAR) u Veneciji.Organizacija-domaćin: Institute of Marine Sciences – National Research Council (CNR-ISMAR)]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16045</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>29401</user_id><user_firstLast_name>Christian Reynolds</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-5322</code><acronim><![CDATA[]]></acronim><duration>11.10.2024 - 10.10.2024</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Biotehnologija, </scie_field_hr><scie_field_en>Biotechnology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci]]></institution_hr><institution_en><![CDATA[University of Rijeka]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16046</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>982</user_id><user_firstLast_name>Maja Katalinić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-4267</code><acronim><![CDATA[]]></acronim><duration>07.10.2024 - 06.10.2024</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut za medicinska istraživanja i medicinu rada]]></institution_hr><institution_en><![CDATA[Institute for Medical Research and Occupational Health]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16049</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>22599</user_id><user_firstLast_name>Neven Šantić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-6223</code><acronim><![CDATA[]]></acronim><duration>10.10.2024 - 09.10.2029</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut za fiziku]]></institution_hr><institution_en><![CDATA[Institute of Physics in Zagreb]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16050</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>83</user_id><user_firstLast_name>Maja Rogić Vidaković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-5310</code><acronim><![CDATA[]]></acronim><duration>10.10.2024 - 09.10.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Split School of Medicine]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16052</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>19051</user_id><user_firstLast_name>Felix Wensveen</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-9441</code><acronim><![CDATA[]]></acronim><duration>19.11.2024 - 18.11.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Medicine]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16057</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4132</user_id><user_firstLast_name>Ivan Marković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-7766</code><acronim><![CDATA[]]></acronim><duration>01.10.2024 - 30.09.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16060</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>573</user_id><user_firstLast_name>Ivana Vinković Vrček</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-8789</code><acronim><![CDATA[]]></acronim><duration>01.11.2024 - 31.10.2024</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut za medicinska istraživanja i medicinu rada]]></institution_hr><institution_en><![CDATA[Institute for Medical Research and Occupational Health]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16062</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>18945</user_id><user_firstLast_name>Sara Godena</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-3327</code><acronim><![CDATA[]]></acronim><duration>23.01.2025 - 22.01.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Institut za poljoprivredu i turizam]]></institution_hr><institution_en><![CDATA[Institute of Agriculture and Tourism in Poreč]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16063</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>20306</user_id><user_firstLast_name>Mateo Gašparović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-8179</code><acronim><![CDATA[]]></acronim><duration>30.09.2024 - 29.09.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Geodezija, </scie_field_hr><scie_field_en>Geodesy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Geodetski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Geodesy]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16064</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5338</user_id><user_firstLast_name>Domagoj Vrsaljko</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-1144</code><acronim><![CDATA[]]></acronim><duration>23.09.2024 - 22.09.2023</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Kemijsko inženjerstvo, </scie_field_hr><scie_field_en>Chemical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet kemijskog inženjerstva i tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Chemical Engineering and Technology]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16065</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>12508</user_id><user_firstLast_name>Blazenka Divjak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-3010</code><acronim><![CDATA[]]></acronim><duration>05.12.2024 - 04.12.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet organizacije i informatike]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Organization and Informatics]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16066</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>7054</user_id><user_firstLast_name>Mirko Poljak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-6324</code><acronim><![CDATA[]]></acronim><duration>23.09.2024 - 22.09.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16067</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4270</user_id><user_firstLast_name>Branimir Bertoša</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-5749</code><acronim><![CDATA[]]></acronim><duration>14.01.2024 - 13.01.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16068</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4750</user_id><user_firstLast_name>Vedran Đerek</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-7531</code><acronim><![CDATA[]]></acronim><duration>07.10.2024 - 06.10.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16069</id><title_hr><![CDATA[Odlazna mobilnost viših asistenata - Maša Filipović]]></title_hr><title_en><![CDATA[]]></title_en><user_id>26491</user_id><user_firstLast_name>Maša Filipović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBODL</proposal_type><proposal_call>2023-12</proposal_call><code>MOBODL-2023-12-6045</code><acronim><![CDATA[]]></acronim><duration>04.06.2024 - 03.01.2026</duration><status>U tijeku</status><financ_value>76.000,00 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Dr. sc. Maša Filipović usavršavat će se na Karolinska institutu u Stockholmu u grupi prof. Bence Réthija. Dr. Filipović će proučavati kako enzim zvan lipaza potaknuta žučnim solima utječe na naš imunološki sustav i razvoj reumatoidnog artritisa, autoimunosne bolesti koja pogađa zglobove. Ovaj enzim obično pomaže u probavi masti, ali nedavna istraživanja sugeriraju da ima i ulogu u obrani tijela od virusa i ulogu u artritisu.Dosadašnji rezultati pokazuju da miševi bez tog enzima imaju manji rizik od artritisa, a pacijenti oboljeli od reumatoidnog artritisa imaju više tog enzima u krvi. To sugerira da bi lipaza potaknuta žučnim solima mogla biti važna za razumijevanje i liječenje ove bolesti.Dr. Filipović će istraživati kako lipaza potaknuta žučnim solima utječe na naše stanice imunološkog sustava te kako se ponaša u upaljenim zglobovima kod ljudi s artritisom. Cilj je bolje razumjeti ove procese kako bismo možda pronašli nove načine liječenja artritisa.Ovo istraživanje može imati velik utjecaj na zdravlje ljudi, ali i društvo općenito, jer se bavi ozbiljnom bolešću koja pogađa mnoge ljude, nerijetko mlade životne dobi. Ako uspijemo bolje razumjeti ulogu tog enzima, to bi moglo otvoriti vrata za primjenu novih terapija ne samo u oboljelih od reumatoidnog artritisa već i od drugih upalnih bolesti. Također, dr. Filipović će kroz ovo istraživanje steći nova znanja i vještine, što će joj pomoći u daljnjem napredovanju u istraživačkoj karijeri.Organizacija-domaćin: Karolinska Institutet, Švedska]]></summary_en></project><project>
<id>16071</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>2923</user_id><user_firstLast_name>Ivan Pejić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-5597</code><acronim><![CDATA[]]></acronim><duration>01.10.2024 - 30.09.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Agronomski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Agriculture]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16073</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1126</user_id><user_firstLast_name>Maroje Sorić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-7035</code><acronim><![CDATA[]]></acronim><duration>23.02.2025 - 24.02.2031</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Javno zdravstvo i zdravstvena zaštita, </scie_field_hr><scie_field_en>Public health and health services, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Kineziološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Kinesiology]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16076</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>11296</user_id><user_firstLast_name>Nils Paar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-1586</code><acronim><![CDATA[]]></acronim><duration>18.03.2025 - 17.03.2031</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16078</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>20884</user_id><user_firstLast_name>Mirta Boban</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-7865</code><acronim><![CDATA[]]></acronim><duration>15.10.2024 - 14.10.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16079</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>7343</user_id><user_firstLast_name>Vlatka Čubrić Čurik</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-7853</code><acronim><![CDATA[]]></acronim><duration>11.10.2024 - 10.10.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Agronomski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Agriculture]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16081</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5962</user_id><user_firstLast_name>Nikola Mišković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-3282</code><acronim><![CDATA[]]></acronim><duration>01.10.2024 - 30.09.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Temeljne tehničke znanosti, </scie_field_hr><scie_field_en>Basic engineering sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16082</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4092</user_id><user_firstLast_name>Marijana Hadzima-Nyarko</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-2448</code><acronim><![CDATA[]]></acronim><duration>17.12.2024 - 16.12.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Građevinarstvo, </scie_field_hr><scie_field_en>Civil engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Građevinski i arhitektonski fakultet Osijek]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Civil Engineering and Architecture Osijek]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16086</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>134</user_id><user_firstLast_name>Višnja Vrdoljak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-2405</code><acronim><![CDATA[]]></acronim><duration>28.10.2024 - 27.10.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16088</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>19224</user_id><user_firstLast_name>Armin Mešić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-7976</code><acronim><![CDATA[]]></acronim><duration>07.10.2024 - 06.10.2029</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16090</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>378</user_id><user_firstLast_name>Ivan Petrović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-6705</code><acronim><![CDATA[]]></acronim><duration>11.09.2024 - 10.09.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16091</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3997</user_id><user_firstLast_name>Željka Mesić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-9940</code><acronim><![CDATA[]]></acronim><duration>25.11.2024 - 24.11.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Agronomski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Agriculture]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16093</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>26395</user_id><user_firstLast_name>Luna Maslov Bandić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-2028</code><acronim><![CDATA[]]></acronim><duration>08.10.2024 - 07.10.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Agronomski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Agriculture]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16096</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5244</user_id><user_firstLast_name>Stjepan Bogdan</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-2504</code><acronim><![CDATA[]]></acronim><duration>01.10.2024 - 30.09.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Temeljne tehničke znanosti, </scie_field_hr><scie_field_en>Basic engineering sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16098</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>18913</user_id><user_firstLast_name>Silvio Hrabar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-8620</code><acronim><![CDATA[]]></acronim><duration>10.09.2024 - 09.09.2023</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16099</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4980</user_id><user_firstLast_name>Marina Babić Čač</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-3550</code><acronim><![CDATA[]]></acronim><duration>19.11.2024 - 18.11.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Medicine]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16101</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>26140</user_id><user_firstLast_name>Stefan Ivić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-1458</code><acronim><![CDATA[]]></acronim><duration>01.11.2024 - 31.10.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Temeljne tehničke znanosti, </scie_field_hr><scie_field_en>Basic engineering sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Tehnički fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Engineering]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16102</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>355</user_id><user_firstLast_name>Srećko Kirin</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-4846</code><acronim><![CDATA[]]></acronim><duration>04.10.2024 - 03.10.2029</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16103</id><title_hr><![CDATA[Odlazna mobilnost viših asistenata - Filip Varga]]></title_hr><title_en><![CDATA[]]></title_en><user_id>19538</user_id><user_firstLast_name>Filip Varga</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBODL</proposal_type><proposal_call>2023-12</proposal_call><code>MOBODL-2023-12-6037</code><acronim><![CDATA[]]></acronim><duration>01.06.2024 - 31.05.2025</duration><status>U tijeku</status><financ_value>48.000,00 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Agronomski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Agriculture]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Analiza genetske raznolikosti samoniklih populacija ljekovitog i aromatičnog bilja od velikog je značaja za uspostavu oplemenjivačkih programa usmjerenih prema razvoju komercijalnih kultivara otpornih na klimatske potrebe. Pojava novih metoda sekvenciranja (kao što je sekvenciranje sljedeće generacije) koje uvelike ubrzavaju razvoj molekularnih biljega te sklapanje genoma zahtjeva i napredna znanja i vještine iz područja bioinformatike kao što su rad sa genomskim serverima te napredno poznavanje programskog jezika Python. U sklopu ovog usavršavanja plan je sekvencirati genome vrsta iz rodova Teucrium i Salvia koji imaju potencijal za razvoj novih kultivara otpornih na promjene klimatskih uvjeta. Upravljanje DNA uzorcima u genetskim laboratorijima ubrzava tijek rada u pripremnim fazama genetskih istraživanja, a uspostava baza podataka za DNA uzorke omogućuje praćenje te ponovnu upotrebu podataka dobivenih molekularnim analizama. Ovo usavršavanje omogućit će uspostavu takve baze podataka za Kolekciju ljekovitog i aromatičnog bilja Nacionalne banke biljnih gena koju održava Zavod za biljnu bioraznolikost Sveučilišta u Zagrebu Agronomskog fakulteta na temelju iskustava djelatnika genetskog laboratorija u sklopu Katedre za genetiku, biotehnologiju, statistiku i oplemenjivanje bilja Biotehničkog fakulteta Sveučilišta u Ljubljani.Organizacija-domaćin: Biotehnički fakultet Sveučilišta u Ljubljani, Slovenija]]></summary_en></project><project>
<id>16105</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>867514</user_id><user_firstLast_name>Edvard Tijan</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-9727</code><acronim><![CDATA[]]></acronim><duration>09.12.2024 - 08.12.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Tehnologija prometa i transport, </scie_field_hr><scie_field_en>Transport technology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Pomorski fakultet ]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Maritime Studies]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16106</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4377</user_id><user_firstLast_name>Igor Stuparevic</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-5476</code><acronim><![CDATA[]]></acronim><duration>09.10.2024 - 08.10.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Biotehnologija, </scie_field_hr><scie_field_en>Biotechnology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Food Technology and Biotechnology]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16108</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>7123</user_id><user_firstLast_name>Igor Krois</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-4027</code><acronim><![CDATA[]]></acronim><duration>01.10.2024 - 30.09.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16110</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4450</user_id><user_firstLast_name>Bojan Žunar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-3849</code><acronim><![CDATA[]]></acronim><duration>16.10.2024 - 15.10.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Biotehnologija, </scie_field_hr><scie_field_en>Biotechnology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Food Technology and Biotechnology]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16111</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3031</user_id><user_firstLast_name>Žarko Kovač</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-8574</code><acronim><![CDATA[]]></acronim><duration>03.10.2024 - 02.10.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Science]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16112</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3715</user_id><user_firstLast_name>Zoran Veršić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-4323</code><acronim><![CDATA[]]></acronim><duration>01.10.2024 - 30.09.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Arhitektura i urbanizam, </scie_field_hr><scie_field_en>Architecture and Urban Environment, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Arhitektonski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Architecture]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16114</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>7618</user_id><user_firstLast_name>Mato Baotić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-9217</code><acronim><![CDATA[]]></acronim><duration>03.09.2024 - 02.09.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Temeljne tehničke znanosti, </scie_field_hr><scie_field_en>Basic engineering sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16115</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1338</user_id><user_firstLast_name>Vilko Mandić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-8186</code><acronim><![CDATA[]]></acronim><duration>01.10.2024 - 30.09.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet kemijskog inženjerstva i tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Chemical Engineering and Technology]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16118</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3612</user_id><user_firstLast_name>Tomislav Jagušt</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-8551</code><acronim><![CDATA[]]></acronim><duration>17.02.2025 - 05.12.2027</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16121</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>13567</user_id><user_firstLast_name>Ivana Buj</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-6869</code><acronim><![CDATA[]]></acronim><duration>15.01.2025 - 14.01.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16122</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>13460</user_id><user_firstLast_name>Nino Krvavica</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-4458</code><acronim><![CDATA[]]></acronim><duration>01.01.2025 - 31.12.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Građevinarstvo, </scie_field_hr><scie_field_en>Civil engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Građevinski fakultet u Rijeci]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Civil Engineering]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16125</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4894</user_id><user_firstLast_name>Marina Bagić Babac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-4101</code><acronim><![CDATA[]]></acronim><duration>13.09.2024 - 12.09.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16126</id><title_hr><![CDATA[Odlazna mobilnost viših asistenata - Jelena Španiček]]></title_hr><title_en><![CDATA[]]></title_en><user_id>867588</user_id><user_firstLast_name>Jelena Španiček</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBODL</proposal_type><proposal_call>2023-12</proposal_call><code>MOBODL-2023-12-8258</code><acronim><![CDATA[]]></acronim><duration>09.09.2024 - 08.11.2025</duration><status>U tijeku</status><financ_value>56.000,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Geologija, </scie_field_hr><scie_field_en>Geology, </scie_field_en><institution_hr><![CDATA[Hrvatski geološki institut]]></institution_hr><institution_en><![CDATA[Croatian Geological Survey]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Znanstvene debate vezane uz globalni događaj koji se dogodio na granici kreda — paleogen (K-Pg) traju već više od pola stoljeća. Brojni dokazi upućuju na postojanje Chicxulub udara nebeskog tijela i posljedičnih geoloških procesa — izvanredne sedimentološke poremećaje i globalno masovno izumiranje — na poluotoku Yucatan u današnjem Meksičkom zaljevu prije oko 66 milijuna godina. Identifikacija K-Pg sedimenata s anomalno visokom koncentracijom iridija (Ir) i ostalih PGE (platinasta skupina elemenata), potaknula je interes za otkrivanjem jasnih geokemijskih signala K-Pg granice.Današnja obala Hrvatske je tijekom mezozoika bila široka i plitka karbonatna platforma — Jadranska karbonatna platforma (JKP). Naslage na kontaktu krede i paleogena uglavnom sadrže stratigrafski hijatus varirajućeg trajanja, što je rezultat okopnjavanja kao posljedica regionalne tektonike. Ipak, u njenom SZ dijelu, na području Krasa/Carso u Sloveniji i Italiji granica je definirana.Naslage granice K-Pg nedavno su po prvi puta sedimentološki, biostratigrafski i geokemijski dokumentirane i u Hrvatskoj, na otoku Hvaru i na otoku Braču. Oba lokaliteta uključuju neuobičajene granične slojeve, naslage koje upućuju na poremećaje vezane uz Chicxulub udar i naknadni tsunami. Različite interpretacije tih naslaga su predmet aktualnih znanstvenih debata, pa je potrebno dalje detaljnije sedimentološko-paleontološko istraživanje i geokemijske analize.Istraživanje dr. sc. Jelene Španiček bi se odvijalo na Zavodu za matematiku, informatiku i geoznanosti Sveučilišta u Trstu, pod mentorstvom izv. prof. dr. sc. Marca Franceschija u razdoblju od rujna 2024. do studenoga .2025. godine. U tom razdoblju bi bila napravljena terenska, laboratorijska i kabinetska istraživanja, te osim standardnih mikropaleontoloških i sedimentoloških metoda istraživanja poseban naglasak bi se stavio na geokemijske analize, kako postojećih uzoraka, tako i uzoraka prikupljenih s novootkrivenih lokacija.Usprkos desetljećima proučavanja, atraktivnost i pitanja oko granice K-Pg ne gube na značaju, ipak se radi o jednom od najvećih i najspektakularnijih masovnih izumiranja u povijesti Zemlje.Organizacija-domaćin: Universita di Trieste, Italija]]></summary_en></project><project>
<id>16127</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>561</user_id><user_firstLast_name>Elvira Bura-Nakić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-6472</code><acronim><![CDATA[]]></acronim><duration>14.10.2024 - 13.10.2029</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Interdisciplinarne prirodne znanosti, </scie_field_hr><scie_field_en>Interdisciplinary natural sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16128</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5659</user_id><user_firstLast_name>Sanja Perić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-5685</code><acronim><![CDATA[]]></acronim><duration>01.04.2025 - 31.03.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Biotehnologija, </scie_field_hr><scie_field_en>Biotechnology, </scie_field_en><institution_hr><![CDATA[Hrvatski šumarski institut]]></institution_hr><institution_en><![CDATA[Croatian Forest Research Institute]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16132</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4348</user_id><user_firstLast_name>Natalija Filipović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-1579</code><acronim><![CDATA[]]></acronim><duration>09.10.2024 - 08.10.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Split School of Medicine]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16134</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5594</user_id><user_firstLast_name>Valerije Vrček</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-7238</code><acronim><![CDATA[]]></acronim><duration>05.02.2025 - 04.02.2031</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Farmaceutsko-biokemijski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Pharmacy and Biochemistry]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16137</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>361</user_id><user_firstLast_name>Siniša Šegvić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-2288</code><acronim><![CDATA[]]></acronim><duration>01.10.2024 - 30.09.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16138</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>7001</user_id><user_firstLast_name>Tomislav Capuder</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-4570</code><acronim><![CDATA[]]></acronim><duration>13.09.2024 - 12.09.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16139</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4749</user_id><user_firstLast_name>Stana Tokić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-5575</code><acronim><![CDATA[]]></acronim><duration>24.10.2024 - 23.10.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Medicinski fakultet Osijek]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Medicine]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16141</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>19274</user_id><user_firstLast_name>Dinko Oletić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-6384</code><acronim><![CDATA[]]></acronim><duration>18.02.2025 - 17.02.2031</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16145</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>29523</user_id><user_firstLast_name>Goran Knežević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-4888</code><acronim><![CDATA[]]></acronim><duration>01.10.2024 - 30.09.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera Osijek, Fakultet elektrotehnike, računarstva i informacijskih tehnologija Osijek]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Electrical Engineering, Computer Science and Information Technology Osijek]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16146</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>829</user_id><user_firstLast_name>Jadranka Šepić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-7076</code><acronim><![CDATA[]]></acronim><duration>11.10.2024 - 10.10.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Geofizika, </scie_field_hr><scie_field_en>Geophysics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Science]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16147</id><title_hr><![CDATA[Odlazna mobilnost viših asistenata - Ante Bećir]]></title_hr><title_en><![CDATA[]]></title_en><user_id>867090</user_id><user_firstLast_name>Ante Bećir</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBODL</proposal_type><proposal_call>2023-12</proposal_call><code>MOBODL-2023-12-1385</code><acronim><![CDATA[]]></acronim><duration>16.09.2024 - 15.09.2025</duration><status>U tijeku</status><financ_value>48.000,00 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Povijest, </scie_field_hr><scie_field_en>History, </scie_field_en><institution_hr><![CDATA[Hrvatski institut za povijest]]></institution_hr><institution_en><![CDATA[Croatian Institute of History]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Znanstveno-istraživački boravak i usavršavanje u trajanju od jedne godine na Sveučilištu u Bologni omogućilo bi krajnjem korisniku dr. sc. Anti Bećiru stjecanje novih znanja i vještina, kao i ostvarivanje novih znanstvenih kontakata unutar međunarodne akademske zajednice, što bi sve bilo od velike važnosti za put prema znanstvenoj izvrsnosti u istraživanju i razumijevanju povijesti kasnosrednjovjekovnih dalmatinskih, odnosno istočno-jadranskih gradova, odnosno posebice što se tiče pitanja kulture vlasti, oblikovanja društvenih i političkih elita, razvoja institucija i normativnoga poretka, odnosno dinamike društva i procesa socijalne diferencijacije. Stvaranje novoga fonda znanja o kasnosrednjovjekovnim istočno-jadranskim gradovima bi doprinijelo sveopćem razumijevanju srednjovjekovne i predmoderne povijesti jadranskoga dijela današnje Republike Hrvatske. U tom smislu, rad u arhivskim institucijama u prije svega Bologni, Firenci, Veneciji i Anconi svakako bi iznjedrio nova saznanja o povijesti jadranskoga prostora i učinio krajnjega korisnika kompetentnijim za buduće znanstvene izazove i istraživačke obaveze pri Odjelu za srednjovjekovnu povijest. No osim traganja za novim podacima o kasnosrednjovjekovnim dalmatinskim gradovima, iza usavršavanja postoji i namjera za komparativnim proučavanjem sjeverno-talijanskih i dalmatinskih gradova kako bi se time stekla cjelovita slika društvenih i političkih gibanja na istočno-jadranskom prostoru, uklopljena u širi povijesni kontekst. Osim toga, gostujući istraživač ostvario bi kontakte koji bi doprinijeli razvoju međunarodne suradnje, potrebne za daljnje usavršavanje i uspješnost vlastite znanstvene karijere, kao i za uspostavu suradnje između hrvatskih i inozemnih povjesničara i znanstveno-istraživačkih institucija.Organizacija-domaćin: Sveučilište u Bologni, Italija]]></summary_en></project><project>
<id>16150</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5374</user_id><user_firstLast_name>Larisa Zoranić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-3193</code><acronim><![CDATA[]]></acronim><duration>03.10.2024 - 02.10.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Science]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16151</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6955</user_id><user_firstLast_name>Tomislav Suligoj</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-6841</code><acronim><![CDATA[]]></acronim><duration>16.09.2024 - 15.09.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16153</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3207</user_id><user_firstLast_name>Damir Medak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-4628</code><acronim><![CDATA[]]></acronim><duration>21.11.2024 - 20.11.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Geodezija, </scie_field_hr><scie_field_en>Geodesy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Geodetski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Geodesy]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16154</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>25587</user_id><user_firstLast_name>Antica Čulina</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-3865</code><acronim><![CDATA[]]></acronim><duration>10.10.2024 - 09.10.2029</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Interdisciplinarne prirodne znanosti, </scie_field_hr><scie_field_en>Interdisciplinary natural sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16157</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>350</user_id><user_firstLast_name>Tanja Jurkin</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-1868</code><acronim><![CDATA[]]></acronim><duration>11.11.2024 - 10.11.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16158</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5498</user_id><user_firstLast_name>Tomislav Kurevija</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-6610</code><acronim><![CDATA[]]></acronim><duration>23.09.2024 - 22.09.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Rudarstvo, nafta i geološko inženjerstvo, </scie_field_hr><scie_field_en>Mining, petroleum and geological engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Rudarsko-geološko-naftni fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mining, Geology and Petroleum Engineering]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16160</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6613</user_id><user_firstLast_name>Dean Ban</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-7709</code><acronim><![CDATA[]]></acronim><duration>03.02.2025 - 02.02.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Institut za poljoprivredu i turizam]]></institution_hr><institution_en><![CDATA[Institute of Agriculture and Tourism in Poreč]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16162</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>12906</user_id><user_firstLast_name>Ivica Smojver</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-8689</code><acronim><![CDATA[]]></acronim><duration>08.10.2024 - 07.10.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Zrakoplovstvo, raketna i svemirska tehnika, </scie_field_hr><scie_field_en>Aerospace, missile and space engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16163</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4834</user_id><user_firstLast_name>Ilija Brizić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-7325</code><acronim><![CDATA[]]></acronim><duration>21.10.2024 - 20.10.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Medicine]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16166</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4682</user_id><user_firstLast_name>Vanda Juranić Lisnić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-9310</code><acronim><![CDATA[]]></acronim><duration>11.11.2024 - 10.11.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Medicine]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16167</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>20436</user_id><user_firstLast_name>Vladimir Zebec</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-6759</code><acronim><![CDATA[]]></acronim><duration>27.11.2024 - 27.11.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Fakultet agrobiotehničkih znanosti Osijek]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Agrobiotechnical Sciences in Osijek]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16168</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>25628</user_id><user_firstLast_name>Andreja Brigić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-4766</code><acronim><![CDATA[]]></acronim><duration>01.12.2024 - 30.11.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16169</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4960</user_id><user_firstLast_name>Hrvoje Kozmar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-8859</code><acronim><![CDATA[]]></acronim><duration>15.10.2024 - 14.10.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, </scie_field_hr><scie_field_en>Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16171</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4941</user_id><user_firstLast_name>Tihana Lenac Roviš</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-1336</code><acronim><![CDATA[]]></acronim><duration>21.10.2024 - 20.10.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Medicine]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16172</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6996</user_id><user_firstLast_name>Marko Delimar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-5960</code><acronim><![CDATA[]]></acronim><duration>01.10.2024 - 30.09.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16174</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>12330</user_id><user_firstLast_name>Vlatka Filipović Marijić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-2486</code><acronim><![CDATA[]]></acronim><duration>10.10.2024 - 09.10.2029</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Interdisciplinarne prirodne znanosti, </scie_field_hr><scie_field_en>Interdisciplinary natural sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16175</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>2707</user_id><user_firstLast_name>Sanja Matić-Skoko</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-5372</code><acronim><![CDATA[]]></acronim><duration>17.09.2024 - 16.09.2029</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut za oceanografiju i ribarstvo]]></institution_hr><institution_en><![CDATA[Institute of Oceanography and Fisheries]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16177</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>11305</user_id><user_firstLast_name>Koraljka Gall Trošelj</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-7885</code><acronim><![CDATA[]]></acronim><duration>26.09.2025 - 25.09.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16178</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>27172</user_id><user_firstLast_name>Tomislav Marković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-8635</code><acronim><![CDATA[]]></acronim><duration>01.10.2024 - 30.09.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16179</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>21443</user_id><user_firstLast_name>Željka Lučev Vasić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-3586</code><acronim><![CDATA[]]></acronim><duration>01.10.2024 - 30.09.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16180</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4400</user_id><user_firstLast_name>Elda Vitanović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-7422</code><acronim><![CDATA[]]></acronim><duration>04.10.2024 - 03.10.2029</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Institut za jadranske kulture i melioraciju krša]]></institution_hr><institution_en><![CDATA[Institute for Adriatic Crops and Karst Reclamation in Split]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16181</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6511</user_id><user_firstLast_name>Sanja Radeka</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-2768</code><acronim><![CDATA[]]></acronim><duration>24.09.2024 - 23.09.2029</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Institut za poljoprivredu i turizam]]></institution_hr><institution_en><![CDATA[Institute of Agriculture and Tourism in Poreč]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16182</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1408</user_id><user_firstLast_name>Ivan Kraus</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-3952</code><acronim><![CDATA[]]></acronim><duration>05.12.2024 - 04.12.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Građevinarstvo, </scie_field_hr><scie_field_en>Civil engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Građevinski i arhitektonski fakultet Osijek]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Civil Engineering and Architecture Osijek]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16183</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>19313</user_id><user_firstLast_name>Monika Zovko</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-9755</code><acronim><![CDATA[]]></acronim><duration>20.12.2024 - 19.12.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Agronomski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Agriculture]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16185</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>866101</user_id><user_firstLast_name>Nina Kamčev</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-6989</code><acronim><![CDATA[]]></acronim><duration>20.11.2024 - 31.12.2029</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16186</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>2709</user_id><user_firstLast_name>Maja Resman</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-2303</code><acronim><![CDATA[]]></acronim><duration>17.10.2024 - 16.10.2024</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16188</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>867580</user_id><user_firstLast_name>Vlado Frančić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-1701</code><acronim><![CDATA[]]></acronim><duration>14.04.2025 - 13.04.2031</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Tehnologija prometa i transport, </scie_field_hr><scie_field_en>Transport technology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Pomorski fakultet ]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Maritime Studies]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16192</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>451</user_id><user_firstLast_name>Jelena Godrijan</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-3474</code><acronim><![CDATA[]]></acronim><duration>08.10.2024 - 07.10.2029</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Interdisciplinarne prirodne znanosti, </scie_field_hr><scie_field_en>Interdisciplinary natural sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16193</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3217</user_id><user_firstLast_name>Tanja Šegvić Bubić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-4474</code><acronim><![CDATA[]]></acronim><duration>17.09.2024 - 16.09.2029</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Institut za oceanografiju i ribarstvo]]></institution_hr><institution_en><![CDATA[Institute of Oceanography and Fisheries]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16194</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6570</user_id><user_firstLast_name>Ivana Šola</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-2396</code><acronim><![CDATA[]]></acronim><duration>11.11.2024 - 10.11.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16195</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6893</user_id><user_firstLast_name>Marko Bosiljevac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-4826</code><acronim><![CDATA[]]></acronim><duration>03.02.2025 - 02.02.2031</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16196</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6243</user_id><user_firstLast_name>Olja Vidjak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-4258</code><acronim><![CDATA[]]></acronim><duration>17.09.2024 - 16.09.2029</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut za oceanografiju i ribarstvo]]></institution_hr><institution_en><![CDATA[Institute of Oceanography and Fisheries]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16198</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>2848</user_id><user_firstLast_name>Nađa Došlić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-8596</code><acronim><![CDATA[]]></acronim><duration>01.04.2025 - 31.03.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16199</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>11149</user_id><user_firstLast_name>Joško Deur</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-2091</code><acronim><![CDATA[]]></acronim><duration>01.10.2024 - 30.09.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, </scie_field_hr><scie_field_en>Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16201</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5240</user_id><user_firstLast_name>Ksenija Zahradka</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-5098</code><acronim><![CDATA[]]></acronim><duration>15.10.2024 - 14.10.2029</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16202</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4336</user_id><user_firstLast_name>Osor  Slaven Barišić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-9195</code><acronim><![CDATA[]]></acronim><duration>28.10.2024 - 14.12.2028</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut za fiziku]]></institution_hr><institution_en><![CDATA[Institute of Physics in Zagreb]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16203</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>25928</user_id><user_firstLast_name>Josip Balen</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-6527</code><acronim><![CDATA[]]></acronim><duration>09.09.2024 - 08.09.2024</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera Osijek, Fakultet elektrotehnike, računarstva i informacijskih tehnologija Osijek]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Electrical Engineering, Computer Science and Information Technology Osijek]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16204</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5079</user_id><user_firstLast_name>Ivana Podnar Žarko</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-1182</code><acronim><![CDATA[]]></acronim><duration>16.10.2024 - 15.10.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16207</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>7444</user_id><user_firstLast_name>Tomislav Stipančić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-1790</code><acronim><![CDATA[]]></acronim><duration>22.10.2024 - 21.10.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, </scie_field_hr><scie_field_en>Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16208</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>2914</user_id><user_firstLast_name>Marijana Hranjec</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-6691</code><acronim><![CDATA[]]></acronim><duration>14.10.2024 - 13.10.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet kemijskog inženjerstva i tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Chemical Engineering and Technology]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16212</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1010</user_id><user_firstLast_name>Igor Karšaj</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-6116</code><acronim><![CDATA[]]></acronim><duration>09.10.2024 - 08.10.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, </scie_field_hr><scie_field_en>Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16213</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>12895</user_id><user_firstLast_name>Matea Zajc Petranović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-2680</code><acronim><![CDATA[]]></acronim><duration>01.10.2024 - 30.09.2029</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut za antropologiju]]></institution_hr><institution_en><![CDATA[Institute for Anthropological Research]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16214</id><title_hr><![CDATA[Odlazna mobilnost viših asistenata - Ana Filošević Vujnović]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4624</user_id><user_firstLast_name>Ana Filošević Vujnović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBODL</proposal_type><proposal_call>2023-12</proposal_call><code>MOBODL-2023-12-7491</code><acronim><![CDATA[]]></acronim><duration>30.09.2024 - 29.09.2025</duration><status>U tijeku</status><financ_value>48.000,00 eur</financ_value><scie_area_hr>Interdisciplinarno područje znanosti</scie_area_hr><scie_area_en>Interdisciplinary scientific area</scie_area_en><scie_field_hr>Biotehnologija u biomedicini, </scie_field_hr><scie_field_en>Biotechnology in Biomedicine, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Fakultet biotehnologije i razvoja lijekova]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Biotechnology and Drug Development]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Ana istražuje kako ovisnost o drogama utječe na strukturu i funkciju mozga, fokusirajući se na koncept neuralne plastičnosti, odnosno sposobnost mozga da se mijenja tijekom vremena pod utjecajem vanjskih čimbenika. Osobito ju zanima vrsta genetske promjene koja se naziva modifikacija RNK, točnije N6-metiladenozin (m6A) RNK metilacija. Ova modifikacija potencijalno ima važnu ulogu u tome kako mozak odgovara na primjenu različitih vrsta i doza pshiostimulansa te utječe na preduvjete kojima podjedinici koji su izloženi drogama postaju ovisni, dok neki ipak ne. Za svoje istraživanje razvoja ovisnosti Ana koristi model organizam vinske mušice, s ciljem da shvati kako genetske promjene utječu na ovisnost te kako bi se moglo doprinijeti razvoju boljih tretmana prevencije i liječenja ovisnosti.Organizacija-domaćin: Scuola Internazionale Superiore di Studi Avanzati (SISSA), Italija]]></summary_en></project><project>
<id>16215</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>835</user_id><user_firstLast_name>Budimir Kliček</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-1262</code><acronim><![CDATA[]]></acronim><duration>27.01.2025 - 26.01.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16218</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3398</user_id><user_firstLast_name>Marijana Serdar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-4676</code><acronim><![CDATA[]]></acronim><duration>04.11.2024 - 03.11.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Temeljne tehničke znanosti, </scie_field_hr><scie_field_en>Basic engineering sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Građevinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Civil Engineering]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16219</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6650</user_id><user_firstLast_name>Ino Čurik</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-2062</code><acronim><![CDATA[]]></acronim><duration>11.10.2024 - 10.10.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Agronomski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Agriculture]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16223</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>13012</user_id><user_firstLast_name>Neven Duić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-7686</code><acronim><![CDATA[]]></acronim><duration>08.10.2024 - 07.10.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, </scie_field_hr><scie_field_en>Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16225</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>12596</user_id><user_firstLast_name>Darko Vasić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-3463</code><acronim><![CDATA[]]></acronim><duration>01.10.2024 - 30.09.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16227</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5410</user_id><user_firstLast_name>Ticijana Ban</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-1693</code><acronim><![CDATA[]]></acronim><duration>17.02.2025 - 31.10.2028</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut za fiziku]]></institution_hr><institution_en><![CDATA[Institute of Physics in Zagreb]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16228</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>28996</user_id><user_firstLast_name>Lado Kranjčević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-3253</code><acronim><![CDATA[]]></acronim><duration>01.11.2024 - 31.10.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Temeljne tehničke znanosti, </scie_field_hr><scie_field_en>Basic engineering sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Tehnički fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Engineering]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16232</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3466</user_id><user_firstLast_name>Maja Jukić Špika</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-2561</code><acronim><![CDATA[]]></acronim><duration>10.10.2024 - 09.10.2024</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Prehrambena tehnologija, </scie_field_hr><scie_field_en>Food technology, </scie_field_en><institution_hr><![CDATA[Institut za jadranske kulture i melioraciju krša]]></institution_hr><institution_en><![CDATA[Institute for Adriatic Crops and Karst Reclamation in Split]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16236</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4924</user_id><user_firstLast_name>Igor Lukić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-5136</code><acronim><![CDATA[]]></acronim><duration>15.10.2024 - 14.10.2029</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Prehrambena tehnologija, </scie_field_hr><scie_field_en>Food technology, </scie_field_en><institution_hr><![CDATA[Institut za poljoprivredu i turizam]]></institution_hr><institution_en><![CDATA[Institute of Agriculture and Tourism in Poreč]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16237</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3160</user_id><user_firstLast_name>Rade Garić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-2887</code><acronim><![CDATA[]]></acronim><duration>15.10.2024 - 14.10.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Dubrovniku]]></institution_hr><institution_en><![CDATA[University of Dubrovnik]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16241</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>346</user_id><user_firstLast_name>Ines Primožič</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-1323</code><acronim><![CDATA[]]></acronim><duration>11.11.2024 - 10.11.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16242</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5769</user_id><user_firstLast_name>Janoš Terzić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-7217</code><acronim><![CDATA[]]></acronim><duration>28.10.2024 - 27.10.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Split School of Medicine]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16244</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>11110</user_id><user_firstLast_name>Smiljana Goreta Ban</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-7995</code><acronim><![CDATA[]]></acronim><duration>04.02.2025 - 03.02.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Institut za poljoprivredu i turizam]]></institution_hr><institution_en><![CDATA[Institute of Agriculture and Tourism in Poreč]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16245</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>19215</user_id><user_firstLast_name>Tomislav Cigula</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-8880</code><acronim><![CDATA[]]></acronim><duration>16.09.2024 - 15.09.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Grafička tehnologija, </scie_field_hr><scie_field_en>Graphics technology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Grafički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Graphic Arts]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16246</id><title_hr><![CDATA[]]></title_hr><title_en><![CDATA[]]></title_en><user_id>13406</user_id><user_firstLast_name>Zvonko Kostanjčar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK-NPOO</proposal_type><proposal_call>2023-10</proposal_call><code>DOK-NPOO-2023-10-6353</code><acronim><![CDATA[]]></acronim><duration>01.10.2024 - 30.09.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16254</id><title_hr><![CDATA[Dolazna mobilnost viših asistenata - Damir Pajić]]></title_hr><title_en><![CDATA[]]></title_en><user_id>2787</user_id><user_firstLast_name>Damir Pajić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOL</proposal_type><proposal_call>2023-12</proposal_call><code>MOBDOL-2023-12-6938</code><acronim><![CDATA[]]></acronim><duration>07.10.2024 - 06.10.2025</duration><status>U tijeku</status><financ_value>43.500,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Hibridni organsko-anorganski halogenometalati(ll) su slojeviti materijali u kojima su dvodimenzionalne anorganske halogenometalatne ravnine slabom van der Waalsovom ili vodikovom vezom vezani sa slojevima organskih molekula, pored prisutne ionske veze. Kako anorganske ravnine mogu imati magnetsko uređenje, a organski slojevi električno, ovakve strukture omogućavaju koegzistenciju, pa i međudjelovanje ova dva uređenja koje može dovesti do magnetoelektričnosti, što pak ima velik potencijal za izgradnju niskonaponskih uređaja za pohranu podataka i nanoelektroničkih sklopova.Slaba veza između organskog i anorganskog dijela s druge strane omogućava veliku fleksibilnost u izboru i jednog i drugog sloja koji bi izgrađivali strukturu, što može rezultirati strukturama s različitim uređenim fazama i kompliciranim faznim prijelazima. Do sada je razumijevanje kako magnetskog i električnog uređenja posebno, tako i njihovog vezanja, u literaturi manjkavo i nepotpuno. Tako je za neke organsko-anorganske halogenometalate nađeno da imaju trodimenzionalno magnetsko uređenje, dok drugi pak imaju dvodimenzionalno, što je tek djelomično opisano teorijski, a naročito je zanimljivo pitanje zašto se neki urede feromagnetski, neki antiferomagnetski, kao i pojava metamagnetizma ili slabog feromagnetizma. S druge strane, postoji nekoliko prijedloga na koji način ugađati električno uređenje ovakvih sustava.Ovaj projekt bi pomogao u rasvjetljavanju prirode magnetskih uređenja organsko-anorganskih halogenometalata(ll) kao teorijska potpora postojećem projektu sistematičnog multidisciplinarnog eksperimentalnog istraživanja izabranih materijala u ovoj skupini. Konkretnim računima iz prvih principa temeljenim na teoriji funkcionala gustoće pomoću superračunala proučavat će se tri skupine materijala: tetraklorokuprati s različitim organskim kationima, tetrahalogenokuprati s različitim halogenim mostovima i tetrahalogenometalati s različitim metalima. Osim podrške u analizi ovih materijala posebno, očekuje se steći i općenitiji uvid u prirodu hibridnih organsko-anorganskih halogenometalata, budući da je plan sistematično varirati gradivne elemente takvih struktura i promatrati izazvane promjene svojstava.Gostujući istraživač: dr. sc. Mihovil Bosnar]]></summary_en></project><project>
<id>16256</id><title_hr><![CDATA[Dolazna mobilnost viših asistenata - Ivica Vilibić]]></title_hr><title_en><![CDATA[]]></title_en><user_id>195</user_id><user_firstLast_name>Ivica Vilibić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOL</proposal_type><proposal_call>2023-12</proposal_call><code>MOBDOL-2023-12-5512</code><acronim><![CDATA[]]></acronim><duration>01.06.2024 - 30.04.2026</duration><status>U tijeku</status><financ_value>83.375,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Geofizika, </scie_field_hr><scie_field_en>Geophysics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Klimatske promjene i njihova manifestacija u Jadranu već su naša sadašnjost kao i budućnost, a u moru se očituju na razne načine — porastom temperature i saliniteta mora, promjenama u količini hranjiva, promjenama u živom svijetu i dolaskom invazivnih vrsta iz toplijih mora, porastom razine mora i plavljenjem obalnih područja, i drugo. U tom smislu, promjene su kulminirale tijekom 2017., kada je opažen skok u termohalinim i biogeokemijskim svojstvima Jadrana, i to ,novo normalno i dalje traje i zahvaća cijeli stupac mora, uključivo i najdublje slojeve mora u Južnojadranskoj kotlini. Osim preliminarnih istraživanja samih promjena, mi zapravo ne znamo koliko su one stvarno izražene, zašto se događaju i hoće li se nastaviti ili pojačati u budućnosti. Kroz istraživačko gostovanje dr. sc. Elene Terzić, koja je mlada znanstvenica sa iskustvom u analizama dugoročnih nizova oceanografskih podataka, pokušalo bi se naći odgovor na postavljena pitanja. Time bi se ostvarilo bolje razumijevanje dinamičkih i biogeokemijskih svojstava Jadrana, što bi omogućilo predviđanje samih promjena, kao i upravljanje odnosno prilagodba na njih. Ovo potonje je nužnost u smislu upravljanja Jadranom i njegovim obalnim područjima, što uključuje očuvanje bioraznolikosti, održivo ribarstvo, kao i klimatske hazarde u obalnim područjima (npr. prilagodba plavljenju obalnih područja).Gostujući istraživač: dr. sc. Elena Terzić]]></summary_en></project><project>
<id>16257</id><title_hr><![CDATA[Odlazna mobilnost viših asistenata - Zdenka Brzović]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3788</user_id><user_firstLast_name>Zdenka Brzović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBODL</proposal_type><proposal_call>2023-12</proposal_call><code>MOBODL-2023-12-4112</code><acronim><![CDATA[]]></acronim><duration>15.12.2024 - 14.12.2025</duration><status>U tijeku</status><financ_value>48.000,00 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filozofija, </scie_field_hr><scie_field_en>Philosophy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Filozofski fakultet u Rijeci]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Klasificiranje različitih entiteta u kategorije je neizmjerno važno kako iz teorijske perspektive, tako i one praktične. Na primjer, klasificiranje u kemijske elemente, elementarne čestice ili biološke vrste. Znanstveno istraživanje svijeta bilo bi nemoguće bez klasifikacija. Kada bi sve stvari oko nas bile jedinstvene i neponovljive na način da ih nije moguće zahvatiti nekim općenitijim kategorijama, ne bismo mogli na sistematičan način istraživati svijet. Svaki novi fenomen kojeg bismo susretali, bio bi potpuno drugačiji, i samim time izmicao bi bilo kakvom uopćavanju, objašnjenju, predviđanju, te kontroli ili utjecaju. Imajući to u vidu, ne čudi da je rasprava o znanstvenim klasifikacijama vrlo plodna, kako unutar samih znanosti, tako i unutar filozofije znanosti. Primjerice u biologiji imamo raspravu o tome možemo li imati jedan točan kriterij za svrstavanje organizama u biološke vrste, a u psihijatriji o tome opisuju li psihijatrijske kategorije neki objektivan fenomen ili se radi o konstruktima koji u većoj mjeri odražavaju društvenu potrebu da izdvoji i izolira pojedince koji se značajno razlikuju od ostatka društva.Tradicionalno, u filozofskim raspravama se podrazumijeva kako će nas (znanstveno) istraživanje svijeta dovesti do otkrivanja stvarnih podjela u svijetu, ili kako je to formulirao Platon (227-279c), do onih koje "režu prirodu po zglobovima". Takve se kategorije u filozofiji nazivaju prirodnim vrstama (engl. natural kinds). Međutim, povijest znanosti nas uči kako je moguće da znanost postulira određene znanstvene kategorije za koje se kasnije pokaže da ne odgovaraju ničemu u svijetu kao što je primjerice eter ili flogiston, ili one čiji su znanstveni temelji u najmanju ruku upitni, poput histerije u psihijatriji. Stoga se filozofske rasprave o prirodnim vrstama bave, između ostalog, pitanjima možemo li uopće imati pristup takvim pravim podjelama u prirodi, te ako možemo, koje kriterije znanstvena kategorija treba ispuniti da bismo je smatrali prirodnom vrstom.Suvremena filozofska rasprava o prirodnim vrstama započinje esencijalističkim gledištima populariziranima od strane Saula Kripkea (1972) i Hilary Putnama (1975). Prema njihovom stajalištu, ključni kriterij za određivanje pripadnosti prirodnoj vrsti je posjedovanje esencije - jedinstvenog svojstva koje dijele svi članovi vrste i koje objašnjava sva važna opažljiva, ali i neopažljiva zajednička svojstva. Primjerice, esencija zlata kao kemijskog elementa jest njegov atomski broj, odnosno struktura atoma zlata koja određuje ostale karakteristike primjeraka tog elementa. Međutim, u novije vrijeme, mnogi ističu neodrživost takvog esencijalizma, naročito kada se radi o znanstvenim kategorijama izvan fizike i kemije, u područjima poput biologije, psihologije, i biomedicinskih znanosti, gdje kategorije koje znanstvenici koriste ne zadovoljavaju stroge esencijalističke uvjete.S ciljem razvoja filozofskih teorija koje bolje odražavaju samu znanstvenu praksu, mnogi autori oslabljuju kriterije koje neko grupiranje mora ispuniti kako bi se smatralo prirodnom vrstom. Ističe se je kako mogućnost objašnjenja i predviđanja pozivanjem na određenu znanstvenu kategoriju dovoljno za pripisivanje statusa prirodne vrste. Takav pristup je doveo do vrlo liberalnog gledišta u pogledu prirodnih vrsta prema kojem broj prirodnih vrsta raste s razvojem znanosti i postavljanjem novih znanstvenih klasifikacija. Takav pristup može imati problematične posljedice jer nekritički preuzima sve trenutne znanstvene kategorije unatoč tome što neke od njih i sami znanstvenici smatraju problematičnima. Primjerice, kriterij za klasificiranje prokariotskih bioloških vrsta sami znanstvenici vrlo često predstavljaju kao pragmatičan i djelomično arbitraran, a određeni filozofi uzimaju kao legitiman primjer prirodne vrste. Posebno su sporna takva gledišta kada se govori o klasifikacijama ljudi i njihovih stanja, primjerice u psihijatriji i drugim biomedicinskim područjima, gdje dijagnoza određenog stanja ili poremećaja sa sobom može donijeti i ozbiljne posljedice kao što su stigmatizacija ili nepotrebna medikalizacija.Cilj ovog projekta jest (1) ponuditi kritiku gore opisanog vrlo liberalnog gledišta na prirodne vrste i (2) razviti filozofsku teoriju prirodnih vrsta koja će dati jasne kriterije što podrazumijevamo pod time da nam je određena znanstvena teorija plodna u generiranju znanstvenih objašnjenja. Naime, prema gledištu koje će se braniti u projektu, različite klasifikacije mogu biti objašnjavalačke (odnosno igrati ulogu u objašnjenjima) u određenoj mjeri ako grupiraju zajedno neka svojstva bez da im pridajemo neki poseban status prirodnih vrsta. Na temelju studija slučaja znanstvenih klasifikacija makromolekula kao što su geni i proteini, te klasifikacija mentalnih poremećaja u psihijatriji, zastupat će se gledište kako prirodne vrste moraju biti objašnjavalački vrlo plodne kategorije gdje je ono što se objašnjava činjenica da članovi vrste dijele velik broj zajedničkih svojstava. Tvrdit će se kako je velik broj znanstvenih kategorija objašnjavalački značajan isključivo u smislu da se znanstvena kategorija koristi u objašnjenju drugih fenomena, u kojem je slučaju moguće da članovi vrste dijele jako malo zajedničkih svojstava. Sukladno tome, slijedit će da je broj znanstvenih kategorija koje možemo smatrati prirodnim vrstama znatno manji od onoga što tvrdi većina trenutno popularnih filozofskih teorija prirodnih vrsta.Organizacija-domaćin: Faculty of Philosophy, University of Cambridge, Ujedinjena Kraljevina]]></summary_en></project><project>
<id>16258</id><title_hr><![CDATA[Odlazna mobilnost viših asistenata - Miha Gunde]]></title_hr><title_en><![CDATA[]]></title_en><user_id>865444</user_id><user_firstLast_name>Miha Gunde</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBODL</proposal_type><proposal_call>2023-12</proposal_call><code>MOBODL-2023-12-6245</code><acronim><![CDATA[]]></acronim><duration>03.06.2024 - 02.06.2025</duration><status>U tijeku</status><financ_value>48.000,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Europa je predana postizanju klimatski neutralnog društva do 2050. Prijelaz s fosilnih goriva na obnovljive izvore energije zahtijeva temeljne promjene u načinu na koji proizvodimo, skladištimo i koristimo energiju. Jedna od važnih komponenti ovog prijelaza su uređaji za pohranu energije (baterije). Skladištenje energije u baterijama visokih performansi izravno je primjenjivo za smanjenje ugljičnog otiska u velikom broju sektora, od transportne i energetske infrastrukture do medicinske, svemirske/robotske i komunikacijske tehnologije. Drugim riječima, baterije su ključna tehnologija u borbi protiv emisija ugljičnog dioksida iz sektora prometa, energije i industrije. Istraživanje i razvoj održivih baterijskih materijala igra jedno od glavnih uloga u EU strategiji za blisku budućnost.Trenutno najrasprostranjeniji dizajn baterija je litiji-ionski dizajn, koji je donio revoluciju u prijenosnoj elektronici u posljednjih 35 godina i izazvao velik porast istraživačkih napora. Međutim, postalo je jasno da je litij teško reciklirati, vrlo je zapaljiv, a povrh svega, rijedak je resurs u Zemljinoj kori. Stoga su istraživački napori usmjereni prema stvaranju alternativnih dizajna baterija. Novi dizajni baterija zahtijevaju materijale različite od onih korištenih u standardnom dizajnu i stoga postoji velika potreba za pronalaženjem materijala s odgovarajućim svojstvima.U ovom projektu proučavat će se jedan od alternativnih dizajna baterija pomoću računalnih simulacija materijala na atomskoj razini. Simulacije se temelje na dobro utvrđenim principima teorijske fizike i kemije, počevši od temeljne kvantne mehanike. S nedavnim uvođenjem metoda temeljenih na strojnom učenju u računalnim istraživanjima, sada je moguće izvoditi simulacije na dugim vremenskim i prostornim skalama na atomskoj razini materijala. Takve simulacije daju informacije o strukturi i atomskoj dinamici materijala koje su relevantne za tumačenje eksperimentalnih mjerenja i čak se mogu koristiti za predviđanje poboljšanja u dizajnu materijala. U tom smislu, rezultati simulacija mogu činiti važan komplement eksperimentalnim istraživanjima i industrijskim naporima u uspješnoj proizvodniji materijala za novu generaciju baterija.Organizacija-domaćin: University of Iceland, The Science Institute]]></summary_en></project><project>
<id>16262</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Martina Bagović]]></title_hr><title_en><![CDATA[]]></title_en><user_id>865178</user_id><user_firstLast_name>Martina Bagović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-2889</code><acronim><![CDATA[]]></acronim><duration>13.05.2024 - 09.08.2024</duration><status>U tijeku</status><financ_value>7.565,00 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Biotehnologija, </scie_field_hr><scie_field_en>Biotechnology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Food Technology and Biotechnology]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Farmaceutska industrija 21. stoljeća pred velikim je izazovima, jer se s jedne strane zahtijeva okretanje zelenim tehnologijama i zaštiti okoliša, a da pritom lijekovi budu što sigurniji i učinkovitiji. Najzastupljeniji nedostatci novih, ali i lijekova postojećih na tržištu, jest njihova slaba topljivost u vodi te slaba permeabilnost. Zelena kemija kao pravac u kemiji razvijen prema načelima očuvanja okoliša sve više koristi nova otapala poput niskotemepraturnih eutektičkih otapala (DES, engl. Deep eutectic solvents). Navedena otapala su sigurna za korištenje, netoksična su, nehlapljiva i imaju vrlo široku mogućnost primjene. Jedna od primjena je i sinteza aktivnih farmaceutskih tvari (API, engl. Active pharamceutical ingredient), odnosno otapanja istih u formulaciji nazvanoj terapeutski DES (THEDES, engl. Therapeutic deep eutectic solvents). Racionalan dizajn i detaljna karakterizacija DES-ova omogućila bi sustavan pristup razvoju novih formulacija THEDES-a. Razvoj novih formulacija lijekova u obliku THEDES-a s očekivanom boljom topljivošću i permeabilnošću te posljedično boljom biodostupnošću, bi osigurao veću učinkovitost i sigurnost lijeka Nadalje, pokušaj umrežavanja THEDES-a u eutoektogelove, što je cilj predloženog stručnog usavršavanja, rezultirao bi razvojem novog načina isporuke lijeka. Postignuti rezultati istraživanja pridonijeli bi razvoju održive farmaceutske proizvodnje, promovirajući ekološku osviještenost i unaprjeđujući učinkovitost konačnog proizvoda.Organizacija-domaćin: National Technical University of Athens]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16263</id><title_hr><![CDATA[Odlazna mobilnost viših asistenata - Jure Krasić]]></title_hr><title_en><![CDATA[]]></title_en><user_id>19170</user_id><user_firstLast_name>Jure Krasić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBODL</proposal_type><proposal_call>2023-12</proposal_call><code>MOBODL-2023-12-3428</code><acronim><![CDATA[]]></acronim><duration>01.09.2024 - 30.09.2025</duration><status>U tijeku</status><financ_value>52.000,00 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Stanice moraju održavati stanje visoke reaktivnosti kako bi imale mogućnost brzog odgovora na vanjske podražaje. U nedavnoj studiji o strukturnim stanicama otkriveno je da stanice održavaju epigenetsko stanje budnosti koje se naziva ,epigenetski potencijal’. Ovo stanje je karakterizirano otvorenim kromatinom u promotorskoj regiji gena, ali relativno niskom razinom ekspresije gena. Stoga se ti geni mogu brzo aktivirati bez potrebe za promjenom epigenetskog stanja promotora. Dok je prethodna studija bila usredotočena na ugrubo razvrstane strukturne stanice, trenutni single-cell atlasi omogućuju analizu jasno odvojenih vrsta stanica. Stoga predlažemo projekt usmjeren na identifikaciju epigenetskog potencijala različitih vrsta stanica ljudskog mozga iz transkriptomskih i epigenomskih single-cell skupova podataka. U tu svrhu razvit ćemo novu metodu temeljenu na analizi single-cell skupa podataka te validirati rezultate naspram različitih podraženih ili poremećenih stanja ljudskog mozga. Ovo istraživanje ima potencijal otkriti temeljne epigenetske mehanizme kontrole gena u tkivu ljudskog mozga relevantne za neurodegenerativne poremećaje i rak.Organizacija-domaćin: Paris Lodron University of Salzburg, Austrija]]></summary_en></project><project>
<id>16264</id><title_hr><![CDATA[Odlazna mobilnost viših asistenata - Stjepan Srhoj]]></title_hr><title_en><![CDATA[]]></title_en><user_id>27231</user_id><user_firstLast_name>Stjepan Srhoj</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBODL</proposal_type><proposal_call>2023-12</proposal_call><code>MOBODL-2023-12-7724</code><acronim><![CDATA[]]></acronim><duration>01.07.2024 - 30.09.2025</duration><status>U tijeku</status><financ_value>60.000,00 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, </scie_field_hr><scie_field_en>Economy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Ekonomski fakultet]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Economics, Business and Tourism]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Docent dr. sc. Stjepan Srhoj zaposlen je na Katedri za opću ekonomiju Ekonomskog fakulteta u Splitu. Obranio je doktorsku disertaciju 2019. godine, dobitnik je Državne nagrade za znanost za znanstvene novake i stipendist Fulbright programa. Dosadašnji znanstveni interes su mu evaluacije javnih politika i ponašanje poduzeća, a kroz usavršavanje nadograđuje znanja, vještine i metode u području dizajna (oblikovanja) tržišta. Dizajn tržišta je područje ekonomije kojim se analizira interakcija kupaca i prodavatelja s pravilima tržišnog mjesta (primjerice digitalne platforme) kako bi se omogućila njihova učinkovita razmjena. Poseban fokus znanstveno-istraživačkog usavršavanja doc. dr. sc. Stjepana Srhoja je na dizajnu specifičnog tržišnog mjesta — digitalnih platformi za javnu nabavu - kojima javne institucije prema procjenama Svjetske Banke kupuju dobra, usluge i radove u vrijednosti većoj od 10 % globalnog bruto domaćeg proizvoda. Zbog kompleksnosti digitalnih platformi za javnu nabavu, usavršavanje obuhvaća i područja industrijske organizacije, teorije aukcija i eksperimentalne ekonomije. Znanstveno-istraživačko usavršavanje provodi se na Odjelu za ekonomiju Sveučilišta Bocconi, jednom od vodećih ekonomskih odjela u Europskoj Uniji, uz mentorstvo prof. dr. sc. Francesca Decarolisa, prethodnog i trenutnog voditelja dvaju European Research Council projekata upravo u temi usavršavanja docenta Srhoja. Planirano usavršavanje ima konkretne rezultate, sistematični pregledni rad i provedeni eksperiment koji doprinose novim spoznajama u području tržišnog dizajna digitalnih platformi za javnu nabavu.Organizacija-domaćin: Sveučilište Bocconi, Italija]]></summary_en></project><project>
<id>16266</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Dora Petrović]]></title_hr><title_en><![CDATA[]]></title_en><user_id>865026</user_id><user_firstLast_name>Dora Petrović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-8489</code><acronim><![CDATA[]]></acronim><duration>15.08.2024 - 30.09.2024</duration><status>U tijeku</status><financ_value>3.995,00 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Psihologija, </scie_field_hr><scie_field_en>Psychology, </scie_field_en><institution_hr><![CDATA[Institut za društvena istraživanja]]></institution_hr><institution_en><![CDATA[Institute for Social Research in Zagreb]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Asistentica Dora Petrović u svom se doktorskom radu bavi odnosom ličnosti i profesionalne dobrobiti učitelja u ranoj fazi karijere. Koristeći pristup usmjeren na osobu, zanima ju identifikacija profila ličnosti učitelja i razlike u radnoj angažiranosti i profesionalnom sagorijevanju učitelja između tih profila. Ovaj pristup, koji se tek nedavno počeo primjenjivati u ispitivanju ličnosti učitelja, omogućuje bolje razumijevanje međudjelovanja osobina ličnosti i njihovu ulogu u određivanju profesionalne dobrobiti učitelja. Ovakav pristup zahtijeva obradu podataka pomoću analize latentnih profila i multigrupnih modela. Dr. sc. Katja Upadyaya, docentica na Sveučilištu u Helsinkiju i njezin istraživački tim imaju višegodišnje iskustvo u istraživanju dobrobiti dionika obrazovnog procesa te u provedbi analize latentnih profila. Ovo bi usavršavanje omogućilo asistentici Petrović da obradi i interpretira podatke svog doktorskog istraživanja te da dobrobit učitelja sagleda iz šire perspektive uz mogućnost usporedbe hrvatskog i finskog obrazovnog sustava. Ovo istraživanje i usavršavanje doprinijelo bi boljem razumijevanju ličnosti učitelja i ulozi ličnosti u objašnjenju njihove profesionalne dobrobiti, koristeći novi i drugačiji metodološki pristup. Identifikacijom profila koji se pokažu kao (ne)adaptivni, omogućit će se jasnije prepoznavanje ranjivih učitelja kojima je podrška u ranoj fazi karijere najpotrebnija. Na taj način se mogu razvijati intervencije s ciljem pravovremenog podržavanja profesionalne dobrobiti učitelja, a posljedično i podržavanja njihove namjere ostanka u profesiji.Organizacija-domaćin: University of Helsinki, Finska]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16267</id><title_hr><![CDATA[Odlazna mobilnost viših asistenata - Paola Kučan Brlić]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5204</user_id><user_firstLast_name>Paola Kučan Brlić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBODL</proposal_type><proposal_call>2023-12</proposal_call><code>MOBODL-2023-12-4587</code><acronim><![CDATA[]]></acronim><duration>02.09.2024 - 01.03.2026</duration><status>U tijeku</status><financ_value>72.000,00 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Medicine]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[U posljednjih nekoliko godina korištenje protutijela koja ciljaju određene proteine na imunološkim stanicama kako bi ih potaknuli u uvjetima kada su one zakočene, kao što je nerijetko slučaj kod tumora, započelo je novu eru liječenja karcinoma. Među nove, obećavajuće mete takve terapije, spadaju proteini iz obitelji nektina koji su u fokusu predloženog usavršavanja i dosadašnjih istraživanja dr. sc. P. Kučan Brlić. Konkretno, fokus ovog usavršavanja je ispitati prikladnost terapeutskog ciljanja ovih proteina u hepatocelularnom karcinomu, trećem najčešćem uzroku smrti od karcinoma globalno. Pritom će dostupnost relevantnih materijala iz pacijenata, zajamčeno ovim usavršavanjem, omogućiti personalizirani pristup istraživanju te se očekuje da će dobivene znanstvene spoznaje znatno doprinijeti razvoju područja što bi jednom moglo dovesti do novih rješenja za učinkovitije liječenje, ranu dijagnostiku ili probir bolesnika. S druge strane, usavršavanje u novih alatima istraživanja (npr. in silico ili miRNA mikroereji), predviđeno ovim projektom, omogućit će dr.sc. Kučan Brlić stjecanje novih ekspertiza koje će moći primijeniti u matičnoj instituciji.Organizacija-domaćin: Italian Liver Foundation NPO (FIF), Italija]]></summary_en></project><project>
<id>16268</id><title_hr><![CDATA[Odlazna mobilnost viših asistenata - Marija Pinterić]]></title_hr><title_en><![CDATA[]]></title_en><user_id>22851</user_id><user_firstLast_name>Marija Pinterić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBODL</proposal_type><proposal_call>2023-12</proposal_call><code>MOBODL-2023-12-5864</code><acronim><![CDATA[]]></acronim><duration>03.06.2024 - 02.06.2025</duration><status>U tijeku</status><financ_value>48.000,00 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Oksidacijski stres je stanje koje nastaje kao rezultat neravnoteže između proizvodnje štetnih molekula zvanih slobodni radikali i sposobnosti tijela da se suprotstavi ili detoksificira njihove štetne učinke. Slobodni radikali su vrio reaktivne molekule koje sadrže kisik i mogu oštetiti stanice, proteine, lipide i DNA unutar tijela. Nastaju kao prirodni nusprodukti raznih metaboličkih procesa, poput pretvorbe hrane u energiju. U zdravom tijelu postoji ravnoteža između slobodnih radikala i antioksidansa, molekula koje mogu neutralizirati i stabilizirati slobodne radikale. Međutim, kada se ta ravnoteža poremeti i postoji višak slobodnih radikala ili manjak antioksidansa, to može dovesti do oksidacijskog stresa. Posljedice ovog stresa uključuju modifikaciju staničnih proteina, lipida i DNA, a smatraju se markerima oksidacijskog stresa. Oksidacijski stres ima bitnu ulogu u razvoju raznih zdravstvenih problema, poput upala, autoimunih bolesti, neurodegenerativnih bolesti, kardiovaskularnih bolesti, razvoja metaboličkog sindroma i raznih vrsta tumora. U sklopu predloženog usavršavanja odredili bismo mogu li se parametri oksidacijskog stresa koristiti kao dijagnostički i prognostički biomarkeri u metaboličkom sindromu i akutnom zatajenju srca. Točnije, provodit ćemo mjerenja različitih parametara oksidacijskog stresa uključujući serumsku aktivnost katalaze, superoksid dismutaze i glutation peroksidaze, uz određivanje oštećenja lipida i proteina u serumu pacijenata s metaboličkim sindromom (N=65), zdravih kontrola (N=65) i bolesnika s akutnim zatajenjem srca (N=315).Organizacija-domaćin: Medical University Graz, Gottfried-Schatz Research Center, Austrija]]></summary_en></project><project>
<id>16269</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Iva Ćurić]]></title_hr><title_en><![CDATA[]]></title_en><user_id>864974</user_id><user_firstLast_name>Iva Ćurić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-6304</code><acronim><![CDATA[]]></acronim><duration>28.04.2024 - 02.08.2024</duration><status>U tijeku</status><financ_value>8.245,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Kemijsko inženjerstvo, </scie_field_hr><scie_field_en>Chemical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet kemijskog inženjerstva i tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Chemical Engineering and Technology]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Sve veća primjena onečišćivala koja stvaraju zabrinutost, kao npr. farmaceutici, dovodi do sve veće prisutnosti tih komponenata u komunalnim otpadnim vodama. Klasični uređaji za obradu otpadnih voda nisu dizajnirani za njihovo potpuno uklanjanje te se te komponente sve više i u većoj koncentraciji nalaze u prihvatnim vodama (jezera, rijeke, podzemne vode) koja ljudi koriste svakodnevno. Prihvatne vode se vrlo često koriste za dobivanje pitke vode i prisutnost farmaceutika dovodi do ugroze ljudi jer na taj način dolazi u prehrambeni lanac. Zbog toga je potrebno unaprijediti ili zamijeniti klasične uređaje za obradu otpadnih voda novim, modernijim procesima. Tlačni membranski procesi pokazali su se jako efikasni u uklanjanju onečišćivala koji stvaraju zabrinutost. U svrhu energetske učinkovitosti istražit će se ultrafiltracija koja iziskuje niže tlakove uz dodatnu primjenu adsorpcije na aktivni ugljen ili ozoniranja.Organizacija-domaćin: TU Wien, Institute of Water Quality and Resource Management]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16270</id><title_hr><![CDATA[Odlazna mobilnost viših asistenata - Ivana Bušelić Garber]]></title_hr><title_en><![CDATA[]]></title_en><user_id>996</user_id><user_firstLast_name>Ivana Bušelić Garber</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBODL</proposal_type><proposal_call>2023-12</proposal_call><code>MOBODL-2023-12-3567</code><acronim><![CDATA[]]></acronim><duration>09.09.2024 - 08.09.2025</duration><status>U tijeku</status><financ_value>48.000,00 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Institut za oceanografiju i ribarstvo]]></institution_hr><institution_en><![CDATA[Institute of Oceanography and Fisheries]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Akvakultura je postala najbrže rastući sektor prehrambene industrije, opskrbljujući trećinu morskih plodova konzumiranih širom svijeta. Brzi rast sektora akvakulture istaknuo je njegova uska grla: (a) zarazne bolesti i (b) održiva hrana za ribe. U sklopu Obzor 2020. projekta AQUA-FAANG stvoreni su opsežni novi funkcionalni genomski skupovi podataka za glavne uzgojne vrste riba u Europi, uključujući lubine. Glavni cilj predloženog usavršavanja je razumjeti funkcionalne mehanizme na kojima se temelji otpornost lubina na zarazne bolesti i poboljšati točnost genomskog predviđanja otpornosti na bolesti korištenjem funkcionalne anotacije. Predloženo usavršavanje omogućit će mladoj istraživačici da olakša uvođenje selektivnih uzgojnih programa, koji se široko koriste u stočarstvu, ali još nisu uobičajeni u uzgoju ribe. Predloženi inovativni pristup omogućio bi razvoj točnijih metoda i alata za selektivni uzgoj. Uvođenjem preciznih tehnika uzgoja (engl. precision breeding) u hrvatsku akvakulturu poboljšala bi se ekološka i ekonomska održivost sektora akvakulture putem smanjenja utjecaja uzgoja na okoliš i povećanja učinkovitosti i kvalitete proizvodnje.Organizacija-domaćin: University of Padua, Department of Comparative Biomedicine and Food Science, Italija]]></summary_en></project><project>
<id>16273</id><title_hr><![CDATA[Odlazna mobilnost viših asistenata - Alen Bjelopetrović]]></title_hr><title_en><![CDATA[]]></title_en><user_id>21286</user_id><user_firstLast_name>Alen Bjelopetrović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBODL</proposal_type><proposal_call>2023-12</proposal_call><code>MOBODL-2023-12-3804</code><acronim><![CDATA[]]></acronim><duration>01.06.2024 - 31.05.2025</duration><status>U tijeku</status><financ_value>48.000,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Razvoj metoda za izravnu i selektivnu zamjenu inertne veze ugljik-vodik vezom ugljik-ugljik od opće je i goleme važnosti za organsku sintezu. Tradicionalni pristupi formiranju veze C—C temelje se na predfunkcionalizaciji supstrata, što obično zahtijeva skupe sintetske postupke te stvaranje neželjenih nusprodukata. Tijekom proteklih nekoliko godina, arilacija veze C—H potpomognuta ionima prijelaznih metala prepoznata je kao snažna kemijska strategija za konstrukciju biarilnih veza. Unatoč značajnom napretku koji je postignut u ovom području, neusmjerena arilacija veze C-H jednostavnih arena bez korištenja suviška reaktanta ostaje veliki izazov sintetske organske kemije. Cilj predloženog usavršavanja je razvoj općih i učinkovitijih protokola funkcionalizacije veze C-H korištenjem metodologije mehanokemijskih sinteza u čvrstom stanju. U ovom projektnom prijedlogu nastojimo prevladati trenutna ograničenja reakcija arilacije veze C-H i drugih srodnih transformacija korištenjem inovativnog katalitičkog sustava temeljenog na kompleksu paladija s S,O-donorskim ligandom, izvođenjem reakcija u uvjetima mehanokemijske sinteze koja predstavlja ekološki prihvatljivu alternativu tradicionalnim reakcijama u otopini.Organizacija-domaćin: University of Amsterdam, Van-t Hoff Institute for Molecular Sciences, Nizozemska]]></summary_en></project><project>
<id>16274</id><title_hr><![CDATA[Odlazna mobilnost viših asistenata - Marijana Matijaš]]></title_hr><title_en><![CDATA[]]></title_en><user_id>22475</user_id><user_firstLast_name>Marijana Matijaš</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBODL</proposal_type><proposal_call>2023-12</proposal_call><code>MOBODL-2023-12-6514</code><acronim><![CDATA[]]></acronim><duration>01.06.2024 - 31.05.2025</duration><status>U tijeku</status><financ_value>48.000,00 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Psihologija, </scie_field_hr><scie_field_en>Psychology, </scie_field_en><institution_hr><![CDATA[Hrvatsko katoličko sveučilište, Zagreb]]></institution_hr><institution_en><![CDATA[Catholic University of Croatia]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Istraživanje Sustainable working conditions in academia survey (STAIRCASE) je dosad najveće istraživanje među znanstvenicima u Europi o njihovoj subjektivnoj dobrobiti i mentalnom zdravlju, a koje se provodi u okviru COST akcije Researcher Mental Health Observatory — ReMO. Svrha ovog istraživanja je steći uvid u uzroke i procese vezane uz dobrobit na radnom mjestu i mentalno zdravije u akademskoj zajednici kako bi se razvile prilagođene i djelotvorne intervencije koje poboljšavaju mentalno zdravlje znanstvenika. Dr. sc. Marijana Matijaš će se u okviru znanstveno-istraživačkog usavršavanja pridružiti istraživačkom timu STAIRCASE istraživanja koje vodi profesor Stefan T. Mol na Amsterdam Business School, University of Amsterdam u Nizozemskoj s ciljem diseminacije rezultata prikupljenih u okviru ovog projekta.Organizacija-domaćin: Amsterdam Business School, University of Amsterdam]]></summary_en></project><project>
<id>16276</id><title_hr><![CDATA[Odlazna mobilnost viših asistenata - Karlo Sović]]></title_hr><title_en><![CDATA[]]></title_en><user_id>19889</user_id><user_firstLast_name>Karlo Sović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBODL</proposal_type><proposal_call>2023-12</proposal_call><code>MOBODL-2023-12-3748</code><acronim><![CDATA[]]></acronim><duration>01.09.2024 - 31.08.2025</duration><status>U tijeku</status><financ_value>48.000,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Projekt Developing interatomic potentials for the catalyzed conversion of C5 and C6 monosaccharides into diols od strane mladog istraživača, dr. sc. Karla Sovića, te mentora-domaćina, Prof. Johannesa T. Margrafa oslanja se na razumijevanju i poboljšanju metoda katalitičkih reakcija transformacije monosaharida u odgovarajuće produkte za daljnju bioenergijsku iskoristivost provedbom state-of-the-art računalnih simulacija s potencijalima generiranim strojnim učenjem. Trenutno je od iznimne važnosti razvijati metode i procese koji će smanjiti ugljični otisak na svijetu, odnosno mjeru ukupne emisije stakleničkih plinova, s ciljem smanjenja upotrebe fosilnih goriva općenito. Ispitivanje i usmjeren dizajn poboljšanja pretvorbe monosaharida u diole na raznim katalitičkim podlogama pruža podroban uvid u reakcijski mehanizam te zajedno s određivanjem iznosa energijskih barijera u raznim uvjetima omogućuje poboljšanje efikasnosti provedbe istog. U tom postupku koriste se kompleksne arhitekture neuronskih mreža zajedno s algoritmima strojnog učenja radi generiranja adekvatnih potencijala nužnih za ispitivanje tijeka promatranih reakcija. Takav računalni pristup omogućuje odgovarajuće uzorkovanje molekularnih konfiguracija na visokoj razini teorije i provedbu Umbrella Integration metode kako bi se odredile konstante brzina kataliziranih reakcija. Projektni plan sadrži cilj određivanja iznosa energijskih barijera pretvorbe monosaharida u diole i cilj određivanja utjecaja promjene ili modifikacije katalitičke podloge na iznose energijskih barijera, a samim time i vrijednosti konstanta brzina tih reakcija. Određivanjem tih vrijednosti za razne modifikacije katalitičke podloge omogućit će se bolji uvid u reakcijski mehanizam promatrane pretvorbe i kvalitetniju analizu utjecaja podloge na sam tijek reakcija. Rezultati tog istraživanja mogu poslužiti u efikasnijem dizajnu dobivanja odgovarajućih produkata za bioenergijsku iskoristivost te samim time potiču razvoj ekološki prihvatljivih procesa.Organizacija-domaćin: Die Universitat Bayreuth, Fakultat fur Biologie, Chemie und Geowissenschaften, Njemačka]]></summary_en></project><project>
<id>16277</id><title_hr><![CDATA[Dolazna mobilnost viših asistenata - Ana Bielen]]></title_hr><title_en><![CDATA[]]></title_en><user_id>18946</user_id><user_firstLast_name>Ana Bielen</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOL</proposal_type><proposal_call>2023-12</proposal_call><code>MOBDOL-2023-12-9061</code><acronim><![CDATA[]]></acronim><duration>31.12.2024 - 01.05.2026</duration><status>U tijeku</status><financ_value>58.253,75 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Interdisciplinarne prirodne znanosti, </scie_field_hr><scie_field_en>Interdisciplinary natural sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Food Technology and Biotechnology]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Jedan od brojnih štetnih učinaka klimatskih promjena jest širenje i povećana incidencija zaraznih bolesti te pojava novih bolesti. Osim postupnog povećanja prosječne temperature, očekuje se da će ekstremni vremenski događaji poput toplinskih valova biti sve učestaliji i imati značajnije posljedice za živi svijet. Međutim, točni učinci takvih temperaturnih promjena na dinamiku bolesti uglavnom su nepoznati, što otežava planiranje mjera za kontrolu bolesti u budućnosti.Boravak dr. Thomasa Baudryja u grupi izv. prof. dr. sc. Ane Bielen na Prehrambeno-biotehnološkom fakultetu Sveučilišta u Zagrebu doprinijet će razumijevanju utjecaja temperaturnih promjena na dinamiku bolesti u slatkovodnim ekosustavima. Kao model koristit ćemo slatkovodne deseteronožne rakove i uzročnika bolesti račje kuge Aphanomyces astaci. Deseteronožni rakovi su ključne vrste slatkovodnih ekosustava, ali su danas ugroženi i to velikim dijelom zbog širenja račje kuge. Budući da je teško predvidjeti utjecaj klimatskih promjena na dinamiku bolesti, dr. sc. Baudry će izložiti A. astaci različitim temperaturnim režimima kako bi dobili uvid u posljedice temperaturnog stresa na patogena na molekularnoj razini. Također, dr. sc. Baudry će primjenom osjetljivih testova za detekciju rakova i A. astaci izravno u DNA uzorcima iz okoliša izraditi kartu distribucije A. astaci i deseteronožnih rakova u Hrvatskoj. To će poslužiti kao polazište za modeliranje promjena u distribuciji ove bolesti pod budućim scenarijima klimatskih promjena.Rezultati ovog istraživačkog boravka biti će preduvjet za predviđanje -žarišta bolesti- u vrijeme klimatskih promjena te razvoj planova zaštite ugroženih populacija slatkovodnih rakova.Gostujući istraživač: dr. sc. Thomas Baudry]]></summary_en></project><project>
<id>16278</id><title_hr><![CDATA[Odlazna mobilnost viših asistenata - Barbara Radovani]]></title_hr><title_en><![CDATA[]]></title_en><user_id>855415</user_id><user_firstLast_name>Barbara Radovani</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBODL</proposal_type><proposal_call>2023-12</proposal_call><code>MOBODL-2023-12-7073</code><acronim><![CDATA[]]></acronim><duration>01.06.2024 - 31.05.2025</duration><status>U tijeku</status><financ_value>48.000,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Fakultet biotehnologije i razvoja lijekova]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Biotechnology and Drug Development]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Upala je glavno obilježje mnogih kroničnih bolesti kao što su autoimune bolesti, metabolički poremećaji te kardiovaskularne bolesti. Sve je veći broj studija u kojima su uočene promjene glikozilacije, najčešće posttranslacijske modifikacije proteina, u različitim upalnim bolestima. No, molekularni mehanizmi putem kojih dolazi do promjena u glikozilaciji proteina i dalje su nedovoljno istraženi. Cilj ovog znanstveno-istraživačkog usavršavanja je rasvijetliti jedan od molekularnih mehanizama koji imaju ključnu ulogu u regulaciji glikozilacije u upali. Posebna pažnja posvećena je interakciji imunoglobulina G (IgG), važne molekule u imunološkom sustavu, i reciklirajućeg endotelnog FcRn receptora u upalnim procesima kako bi produbilo razumijevanje regulacije glikozilacije IgG-a tijekom upale te istražilo ulogu FcRn-a kao potencijalnog ključnog posrednika u tom procesu. Ovo istraživanje će pridonijeti razumijevanju složene regulacije glikozilacije IgG-a u patofiziološkim stanjima, te potencijalno identificirati nove terapeutske mete. Navedeno otvara potencijal za razvoj novih dijagnostičkih alata i terapijskih pristupa za različite bolesti, što bi imalo značajan utjecaj na poboljšanje zdravlja ljudi. Konačno, ovo usavršavanje će pridonijeti proširenju znanstvenog djelovanja i stručnosti mladog istraživača, kroz stjecanje novih i proširenje postojećih znanja u području glikobiologije te razvitak vještina u novim metodologija. Kroz primjenu stečenih znanja i vještina u daljnjim istraživanjima, mladi istraživač će doprinijeti daljnjem napretku u znanstvenoj zajednici.Organizacija-domaćin:  Friedrich-Alexander University Erlangen-Nuremberg, Njemačka]]></summary_en></project><project>
<id>16280</id><title_hr><![CDATA[Odlazna mobilnost viših asistenata - Slaven Jurić]]></title_hr><title_en><![CDATA[]]></title_en><user_id>20213</user_id><user_firstLast_name>Slaven Jurić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBODL</proposal_type><proposal_call>2023-12</proposal_call><code>MOBODL-2023-12-7716</code><acronim><![CDATA[]]></acronim><duration>01.09.2024 - 31.08.2025</duration><status>U tijeku</status><financ_value>48.000,00 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Interdisciplinarne biotehničke znanosti, </scie_field_hr><scie_field_en>Interdisciplinary biotechnical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Agronomski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Agriculture]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Ovo znanstveno-istraživačko usavršavanje usmjereno je na stvaranje novih vrsta jestivih omotača za voće, napravljenih od prirodnih sastojaka. Zamislite da umjesto da bacate plastični omotač s voća, možete ga jednostavno pojesti! Osim što to smanjuje otpad, ovi omotači čine voće dugotrajnijim i zdravijim. U ovom istraživanju korištene su napredne tehnike za pripremu ovih omotača, kao što su tehnika homogenizacije visokim tlakom i upotreba nanotehnologije za stvaranje vrlo malih vlakana (nanovlakana), koja služe za prijenos zdravih biološki aktivnih tvari. Ovi postupci omogućuju maksimalno iskorištavanje isključivo prirodnih sastojaka u svrhu očuvanja svježine voća tijekom perioda skladištenja. Primarni cilj ovog istraživanja je stvoriti pakiranje koje ne samo da čuva hranu, već je i čini zdravijom, a ujedno i smanjuje otpad. Ovo istraživanje predstavlja korak prema budućnosti u kojoj je hrana pakirana na način koji je dobar za naše zdravlje i okoliš.Organizacija-domaćin: Sveučilište u Salernu, Italija]]></summary_en></project><project>
<id>16281</id><title_hr><![CDATA[Dolazna mobilnost viših asistenata - Neven Duić]]></title_hr><title_en><![CDATA[]]></title_en><user_id>13012</user_id><user_firstLast_name>Neven Duić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOL</proposal_type><proposal_call>2023-12</proposal_call><code>MOBDOL-2023-12-7385</code><acronim><![CDATA[]]></acronim><duration>01.10.2024 - 31.10.2025</duration><status>U tijeku</status><financ_value>47.125,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, </scie_field_hr><scie_field_en>Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Kroz provedbu ovog istraživačkog projekta, bit će ostvaren značajan napredak u razvoju i unaprjeđenju modela H2RES. Ova poboljšanja modela imaju za cilj pružanje boljeg uvida u izradu energetskih strategija i klimatskih planova, što je od izuzetnog značaja u kontekstu globalnih izazova kao što su klimatske promjene i održivi razvoj.Povećanje sposobnosti modela H2RES omogućit će detaljniju i precizniju analizu različitih scenarija razvoja energetskog sustava. To uključuje procjenu potencijala primjene različitih tehnologija u energetskom sektoru, kao što su obnovljivi izvori energije, tehnologije pohrane energije i tehnologije za smanjenje emisija ugljičnog dioksida. S ovim unaprjeđenjima, model postaje moćnije sredstvo za planiranje energetske budućnosti, omogućavajući donositeljima odluka da donose informirane odluke koje podržavaju održivi razvoj i smanjenje utjecaja na okoliš.Osim toga, povećane sposobnosti modela H2RES doprinose i boljem razumijevanju ekonomskih aspekata energetskih strategija. To znači da model može pružiti detaljne ekonomske analize vezane uz ulaganja u energetske tehnologije, troškove proizvodnje energije, i potencijalne financijske uštede. Ove informacije su ključne za donošenje odluka koje su ne samo ekološki održive, već i ekonomski isplative.Ukupno gledano, unaprjeđenje modela H2RES kroz ovaj istraživački projekt doprinosi razvoju sofisticiranijih alata za energetsko planiranje, što je od vitalnog značaja za postizanje održivih energetskih sistema i ispunjavanje globalnih klimatskih ciljeva. Ovi napori ne samo da poboljšavaju razumijevanje složenosti energetskih sustava, već također pružaju temelj za stvaranje bolje, čistije i sigurnije energetske budućnosti za sve.Gostujući istraživač: dr.sc. Saqib Ali]]></summary_en></project><project>
<id>16283</id><title_hr><![CDATA[Odlazna mobilnost viših asistenata - Moira Buršić]]></title_hr><title_en><![CDATA[]]></title_en><user_id>27427</user_id><user_firstLast_name>Moira Buršić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBODL</proposal_type><proposal_call>2023-12</proposal_call><code>MOBODL-2023-12-4195</code><acronim><![CDATA[]]></acronim><duration>14.06.2024 - 13.06.2025</duration><status>U tijeku</status><financ_value>48.000,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Interdisciplinarne prirodne znanosti, </scie_field_hr><scie_field_en>Interdisciplinary natural sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište Jurja Dobrile u Puli]]></institution_hr><institution_en><![CDATA[Juraj Dobrila University of Pula]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Cilj znanstveno-istraživačkog usavršavanja jest istraživanje bioraznolikosti Jadranskog mora, s posebnim naglaskom na beskralježnjacima. Kroz pažljivo strukturirane faze usavršavanja, istraživanje će se usredotočiti na provođenje taksonomskih analiza faune unutar naselja crvene alge Corallina officinalis, analize bioloških značajki organizama u raznim vrstama sedimenata, analizu utjecaja invazivnih vrsta, poput plavog raka Callinectes sapidus te korištenje raznih tehnika uzorkovanja podmorja.Očekivani rezultati ovog multidisciplinarnog pristupa uključuju povećanje stručnosti u taksonomskim analizama, produbljeno razumijevanje prilagodbi infaune sedimentnih dna na okolišne promjene, detaljnu analizu utjecaja invazivnih vrsta na priobalnu faunu te stvaranje temelja za buduće istraživačke projekte. Kroz planiranu suradnju između dviju institucija, Sveučilišta Jurja Dobrile u Puli i Morske biološke postaje Piran, projekt se integrira u šire znanstvene projekte i strategije održivog gospodarenja morskim ekosustavima.Ova suradnja također aktivno podržava partnerstva s međunarodnim znanstvenim zajednicama, potiče razmjenu znanja te nastoji integrirati rezultate istraživanja u održive prakse upravljanja morskim okolišem. Kroz ovu suradnju, projekt ima za cilj pridonijeti očuvanju Jadranskog mora, ne samo kroz stručno napredovanje, već i kroz podizanje svijesti o važnosti zaštite morskog okoliša među širom javnošću.Organizacija-domaćin: Nacionalni institut za biologijo, Morska biološka postaja Piran, Slovenija]]></summary_en></project><project>
<id>16284</id><title_hr><![CDATA[Dolazna mobilnost viših asistenata - Neven Alujević]]></title_hr><title_en><![CDATA[]]></title_en><user_id>25884</user_id><user_firstLast_name>Neven Alujević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOL</proposal_type><proposal_call>2023-12</proposal_call><code>MOBDOL-2023-12-5851</code><acronim><![CDATA[]]></acronim><duration>02.06.2024 - 01.05.2026</duration><status>U tijeku</status><financ_value>83.375,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, </scie_field_hr><scie_field_en>Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Gostujući poslijedoktorski istraživač Dr. Fevzi Cakmak BOLAT iz Republike Turske sa Sveučilišta Kocaeli pridružit će se istraživačkoj grupi prof. dr. Nevena Alujevića gdje teorijski i eksperimentalno istražuje aktivne konstrukcije za suzbijanje širokopojasne niskofrekventne buke. Radi se o posebnim konstrukcijama proizvedenim metodama trodimenzijskog ispisa koje su aktivirane povratnim vezama sastavljenih od parova senzora i aktuatora. Kad se takva konstrukcija aktivira, ona daleko slabije provodi zvuk negoli pasivna konstrukcija. Na taj način moguće je ostvariti zaštitu od buke i vibracija na onim mjestima i onda kada je potrebna čak i ako se radi o buci vrlo niskih frekvencija i visokih valnih duljina kakvu se upotrebom klasičnih zvučnih barijera vrlo teško suzbija.Gostujući istraživač: Dr. Fevzi Cakmak BOLAT]]></summary_en></project><project>
<id>16285</id><title_hr><![CDATA[Odlazna mobilnost viših asistenata - Jurica Babić]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6415</user_id><user_firstLast_name>Jurica Babić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBODL</proposal_type><proposal_call>2023-12</proposal_call><code>MOBODL-2023-12-2765</code><acronim><![CDATA[]]></acronim><duration>01.10.2024 - 30.09.2025</duration><status>U tijeku</status><financ_value>48.000,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Digitalne društvene inovacije su inovacije koje se oslanjaju na tehnologiju i mrežne alate s ciljem rješavanja društvenih problema i unaprjeđenja društva. Mladi istraživači (izv. prof. dr. sc. Jurica Babić) posjeduje višegodišnje iskustvo u istraživanju i razvoju takvih inovacija s posebnim naglaskom na rješenja vezana uz društvenu uključenost i zelenu edukaciju. Tema znanstvenog usavršavanja fokusira se na mjerenje i procjenu učinka digitalnih društvenih inovacija koje dolaze iz područja visokog obrazovanja (npr. ozbiljna igra za učenje o pravilnom razvrstavanju otpada). Specifično, glavni istraživački cilj jest razumjeti kako cjelovito mjeriti pozitivne efekte digitalnih društvenih inovacija koja potiču sa sveučilišta, pri čemu će se poseban naglasak staviti na analizu odabranog podskupa programskih rješenja vezanih za društvenu uključenost i zelenu edukaciju. Kako bi se postigli znanstveni rezultati, usavršavanje se provodi na vrhunskom istraživačkom institutu za upravljanje inovacijama i znanjem INGENIO koji djeluje u okviru Sveučilišta u Valenciji. Specifično, mladi istraživač će svoje interdisciplinarno istraživanje provoditi pod mentorstvom profesorice Alejandre Boni Aristizabal, koja je svjetski priznata istraživačica u područjima društvenih inovacija i evaluacije inovacija iz perspektive održivog razvoja. Ovo usavršavanje ima značajan učinak na mladog istraživača budući da će svoja tehnička znanja i vještine vezane uz istraživanje i razvoj digitalnih inovacija nadopuniti vrijednim znanjima i vještinama vezanim uz inovacije i upravljanje znanjem, specifično metodologijom procjene učinka. Nadalje, usavršavanje će imati znanstveni učinak u vidu razvoja inovativnog pristupa procjenjivanja učinka digitalne društvene inovacije koji se oslanja na analitiku podataka dostupnih iz samih proizvoda koji predstavljaju digitalnu društvenu inovaciju (npr. podataka iz ozbiljne igre za učenje o pravilnom razvrstavanju otpada). Konačno, navedeni pristup imat će vrijednost za dionike na institucijskoj razini (npr. fakulteti/poduzeća) s obzirom na to da će pristup omogućiti preciznu informaciju o tome koliko je digitalna društvena inovacija učinkovita, što vlasnicima omogućuje bolje odlučivanje o tome na koji način razvijati, podržati i unaprijediti vlastite digitalne društvene inovacije.Organizacija-domaćin: Instituto de Gestion de la Innovacién y del Conocimiento – INGENIO (CSIC-UPV), Valencia, Španjolska]]></summary_en></project><project>
<id>16286</id><title_hr><![CDATA[Dolazna mobilnost viših asistenata - Marijana Kraljić Roković]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3651</user_id><user_firstLast_name>Marijana Kraljić Roković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOL</proposal_type><proposal_call>2023-12</proposal_call><code>MOBDOL-2023-12-6782</code><acronim><![CDATA[]]></acronim><duration>15.07.2024 - 14.11.2025</duration><status>U tijeku</status><financ_value>58.000,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Kemijsko inženjerstvo, </scie_field_hr><scie_field_en>Chemical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet kemijskog inženjerstva i tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Chemical Engineering and Technology]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[U posljednjih nekoliko godina, globalni izazovi u energetskom sektoru i potreba za očuvanjem okoliša ističu potrebu za razvojem djelotvornijih i održivijih sustava za skladištenje i konverziju energije. Tradicionalne Li-ionske baterije, iako dominantne, suočavaju se s rastućim problemima poput visokih cijena, sigurnosnih rizika i ekoloških problema te problema povezanih s dostupnošću litija. U tom kontekstu, punjive Ca-zrak i Zn-zrak baterije postaju atraktivne alternative, obećavajući niže troškove, smanjenje sigurnosnih rizika i veću dostupnost resursa poput kalcija i cinka. Međutim, njihova praktična primjena suočava se s izazovima, posebno u području punjivosti. Ovaj projekt ima za cilj rješavanje ovog izazova primjenom inovativnih elektrolita, odnosno ionskih tekućine i eutektičkih smjesa, koje karakterizira visoka termička i kemijska stabilnost, niska isparljivost te široka elektrokemijska domena. Fokus istraživanja obuhvaća analizu komercijalno dostupnih ionskih tekućina i kolinskih eutektičkih smjesa kao potencijalnih elektrolita za punjive Ca-zrak i Zn-zrak baterije. Kroz sintezu, karakterizaciju i testiranje elektrolita, Nikola Zdolšek skupa s mentoricom i članovima NATO-SPS projekta “High energy calcium oxygen batteries” planira razviti laboratorijski prototip punjive baterije s unaprjeđenim svojstvima. Ovo istraživanje ne samo da se odnosi na nedavne tehnološke izazove u području punjivih metal-zrak baterija, već pruža originalan doprinos fundamentalnom razumijevanju elektrokemijskih procesa u ovim sustavima, s ciljem olakšavanja njihove tranzicije iz laboratorija u industrijsku primjenu.Gostujući istraživač: Dr.sc. Nikola Zdolšek]]></summary_en></project><project>
<id>16287</id><title_hr><![CDATA[Dolazna mobilnost viših asistenata - Neven Barišić]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4289</user_id><user_firstLast_name>Neven Barišić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOL</proposal_type><proposal_call>2023-12</proposal_call><code>MOBDOL-2023-12-3850</code><acronim><![CDATA[]]></acronim><duration>01.10.2024 - 30.04.2026</duration><status>U tijeku</status><financ_value>68.875,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Multiferoični materijali, koji pokazuju istovremeno feroelektrično i feromagnetsko ponašanje, nude jedinstveni put za dizajniranje naprednih uređaja s višestrukom funkcionalnošću. Vezanje električnih i magnetskih svojstava u ovim materijalima otvara puteve za razvoj najsuvremenijih uređaja, uključujući trajnu memoriju (feroelektrični RAM), magnetoelektrične senzore za detekciju magnetskog polja i spintroničke uređaje koji iskorištavaju koegzistenciju feroelektriciteta i antiferomagnetizma. Osim ovih primjena, multiferoični materijali proširuju svoj utjecaj na različite domene, uključujući piezoelektrične uređaje kao što su senzori, aktuatori i uređaji za prikupljanje energije. Oni također nalaze primjenu u nelinearnim optičkim elementima, mikroelektronici koja sadrži kondenzatore, fotodetektore, fotonaponske ploče i biomedicinske materijale koji iskorištavaju katalitička, fotokatalitička i multiferoična svojstva.Međutim, otključavanje punog potencijala ovih materijala zahtijeva sveobuhvatno razumijevanje temeljnih mehanizama koji upravljaju svojstvima multiferoičnih materijala. Ovo razumijevanje je ključno za upravljanje feroelektričnih i magnetskih karakteristika ovih materijala. Kako bi se riješio ovaj izazov, projekt usvaja sustavni pristup sintezi i karakterizaciji materijala. Cilj je izraditi materijale sa svojstvima koja se mogu kontrolirati putem sinteze, u rasponu od makroskopskih kristala do nanostrukturiranih uzoraka, omogućujući precizne prilagodbe magnetizma, dielektričnog odziva, fotoelektriciteta i drugih efekata.Korištenje naprednih tehnika karakterizacije u projektu obećava sveobuhvatan uvid u elektronička, strukturna i magnetska svojstva multiferoičnih materijala. Naime, fokus na nanostrukturne materijale ima potencijal za razvoj novih nanomaterijala koji bi mogli potaknuti nove tehnologije. Dodatno, ovaj naglasak usklađen je s ciljevima održivosti okoliša istraživanjem materijala koji ne sadrže toksične supstance (Bi i Fe su ekološki prihvatljivi elementi za elektroniku), potencijalno smanjujući onečišćenje okoliša. Doprinosi projekta proširuju se na napredak nanotehnologije, označavajući značajan korak prema inovacijama u znanosti o materijalima.Gostujući istraživač: Dr. Kamila Komedera]]></summary_en></project><project>
<id>16290</id><title_hr><![CDATA[Dolazna mobilnost viših asistenata - Nils Paar]]></title_hr><title_en><![CDATA[]]></title_en><user_id>11296</user_id><user_firstLast_name>Nils Paar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOL</proposal_type><proposal_call>2023-12</proposal_call><code>MOBDOL-2023-12-6026</code><acronim><![CDATA[]]></acronim><duration>01.06.2024 - 30.04.2026</duration><status>U tijeku</status><financ_value>83.375,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Osnovni cilj planiranog usavršavanja gostujućeg višeg asistenta jest istraživanje fizikalnih veličina određenih signalima koji proizlaze iz binarnih sustava pulsara i gravitacijskih valova stvorenih spajanjem neutronskih zvijezda, s ciljem određivanja svojstava nuklearne jednadžbe stanja. Nedavno su spajanja neutronskih zvijezda privukla veliku pažnju, čak i u javnim medijima, zahvaljujući otkriću njihovih gravitacijskih valova, čime je omogućeno praćenje kozmičkog porijekla zlata i drugih težih elemenata u svemiru, što predstavlja jedan od temeljnih ciljeva moderne znanosti. Predviđeni znanstveno-istraživački program mladog istraživača uključuje razvoj originalne metodologije za proučavanje nuklearne jednadžbe stanja putem teorijskog pristupa temeljenog na relativističkom nuklearnom energijskom funkcionalu gustoće. Rezultati istraživanja će omogućiti dublje razumijevanje svojstava nuklearne jednadžbe stanja, ključne za određivanje ekstremnih uvjeta unutar zvijezda i njihovog eksplozivnog kraja života putem eksplozija supernove. Planirano istraživanje će imati snažan učinak na istraživačku karijeru mladog znanstvenika jer će mu biti omogućen pristup naprednim metodama istraživanja i najnovijim znanstvenim spoznajama teorijske fizike kojima će unaprijediti kvalitetu svojeg znanstvenog rada. Usavršavanje u Zagrebu, kao i uključivanje u međunarodnu suradnju sa nizom vodećih istraživačkih grupa u svijetu, također će znatno doprinijeti internacionalizaciji istraživačke karijere višeg asistenta. Stečenim vještinama za suradnju i komunikaciju, rješavanje problema i kritičko razmišljanje, upravljanje vremenom i organizaciju, kao i vještinama za izradu i prijavu znanstveno- istraživačkog projekta, gostujući znanstvenik će nakon završetka usavršavanja biti u. mogućnosti afirmirati se kao samostalni znanstvenik. Provođenjem ovog istraživanja, također će biti ostvareni temelji za uspostavu dugoročne znanstvene suradnje znanstvenika sa sveučilišta u Zagrebu i Solunu, što će biti formalizirano i sklapanjem ugovora o suradnji. Kroz razvoj naprednih numeričkih metoda potrebnih za rješavanje postavljenih problema kompleksnih sustava u nuklearnoj fizici i astrofizici, ovo usavršavanje će također doprinijeti i tehnološkom transferu znanja koje indirektno ima i širi društveni i gospodarski učinak.Gostujući istraživač: Dr. Polychronis Koliogiannis Koutmiridis]]></summary_en></project><project>
<id>16292</id><title_hr><![CDATA[Odlazna mobilnost viših asistenata - Tatjana Mijošek]]></title_hr><title_en><![CDATA[]]></title_en><user_id>21287</user_id><user_firstLast_name>Tatjana Mijošek</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBODL</proposal_type><proposal_call>2023-12</proposal_call><code>MOBODL-2023-12-3135</code><acronim><![CDATA[]]></acronim><duration>17.06.2024 - 16.06.2025</duration><status>U tijeku</status><financ_value>48.000,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Interdisciplinarne prirodne znanosti, </scie_field_hr><scie_field_en>Interdisciplinary natural sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Plastika predstavlja veliki okolišni problem današnjice jer njezina upotreba eksplozivno raste zahvaljujući svojstvima poput stabilnosti, izdržljivosti, niske cijene, mehaničke čvrstoće ili male težine. Plastika se u okolišu raspada na manje komadiće te se komadići <5 mm nazivaju mikroplastikom. Poznato je da su morski ekosustavi preopterećeni mikroplastikom koja posljedično ima štetne učinke i na organizme. lako postoji mnoštvo tipova (mikro)plastike, među najčešćim tipovima u morima su polietilen (i visoke i niske gustoće, HDPE i LDPE) te polipropilen (PP) koji imaju široku upotrebu u svakodnevnom životu. Polietilen redovito koristimo u proizvodima poput plastičnih vrećica, boca za mlijeko, šampona ili motornih ulja, dok PP ima brojne primjene kao materijal za pakiranje, u medicinskoj i elektroničkoj opremi, tekstilnoj i automobilskoj industriji te je zbog tolike rasprostranjenosti važno ispitati njihov utjecaj na okoliš. Nažalost, njihova prisutnost i utjecaj na morske sustave i organizme je nedovoljno istražen. Naime, znamo da se veći komadi plastike poput vrećica ili najlona često mogu zapetljati u probavila kornjača ili dupina te uzrokuju i mehanička i fiziološka oštećenja pa i smrt. Međutim, veliki problem predstavlja i unos sitnije mikroplastike kroz hranu ili sediment u organizme poput rakova, školjkaša ili riba koji potencijalno može imati štetne učinke i za ljude budući da te organizme koristimo u svojoj prehrani te preko njih može doći do unosa mikroplastike i u naš organizam. Takve sitne čestice ponekad uzrokuju oku nevidljive, rane promjene već na razini molekula i stanica. Stoga bi moje istraživanje utjecaja polietilena i polipropilena trebalo donijeti nove informacije o njihovom mogućem štetnom utjecaju na dagnju, rasprostranjenu vrstu školjkaša u našem Jadranskom moru koju često koristimo i u prehrani, ali posredno i o mogućim utjecajima na sve druge organizme u moru, okoliš i ljude. U istraživanju ćemo procijeniti biološke odgovore dagnji na povišene koncentracije mikroplastike tijekom vremena, kao i posljedice vezanja organskih zagađivala na čestice mikroplastike tako da ćemo mjeriti različite biomarkere, odnosno rane promjene u organizmu na razini stanice koje ukazuju na negativno međudjelovanje s vanjskim stresorima. S obzirom na dosadašnja saznanja o mikroplastici očekujemo da ćemo vjerojatno zabilježiti i neke štetne učinke ovih rijetko istraživanih tipova mikroplastike na dagnje te potvrditi potrebu smanjenog korištenja i odlaganja plastike u okoliš, povećane stope recikliranja te provođenja zakonske regulative kojom bi se smanjilo ispuštanje (mikro)plastike u okoliš.Organizacija-domaćin: Nacionalni inštitut za biologijo - Morska biološka postaja Piran, Slovenija]]></summary_en></project><project>
<id>16295</id><title_hr><![CDATA[Odlazna mobilnost viših asistenata - Simona Prijaković]]></title_hr><title_en><![CDATA[]]></title_en><user_id>25362</user_id><user_firstLast_name>Simona Prijaković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBODL</proposal_type><proposal_call>2023-12</proposal_call><code>MOBODL-2023-12-3604</code><acronim><![CDATA[]]></acronim><duration>15.05.2024 - 14.05.2025</duration><status>U tijeku</status><financ_value>48.000,00 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, </scie_field_hr><scie_field_en>Economy, </scie_field_en><institution_hr><![CDATA[Institut za javne financije]]></institution_hr><institution_en><![CDATA[Institute of Public Finance]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Proračuni su ključni za pretvaranje političkih namjera vlasti u konkretne intervencije neophodne za postizanje postavljenih ciljeva. Na temelju složenog planiranja i prognoziranja, proračuni im omogućuju predviđanje prihoda i rashoda za iduća razdoblja (jednu ili više godina) kako bi prikupljenim javnim prihodima mogli realizirati planirana javna dobra i usluge. Proračuni služe i za izvještavanje građana o upravljanju javnim sredstvima. Mjera u kojoj se vlasti drže onoga što su planirali u izglasanim proračunima naziva se vjerodostojnost planiranja proračuna (VPP). VPP je važna jer nakon što je proračun izglasan, građani očekuju da lokalni proračun funkcionira kao putokaz, usmjeravajući javnu potrošnju prema učinkovitom pružanju javnih dobara i usluga i napretku u održivom razvoju. Ako lokalne vlasti ne prate proračun, društvo postavlja pitanje zašto se to dogodilo i postaje zabrinuto zbog povezanih utjecaja. Ponovljena odstupanja smanjuju povjerenje ljudi u sposobnost njihove vlasti da naprave realne planove i pridržavaju se obveza. Za istraživanje VPP-a neophodna je transparentnost proračuna, koja podrazumijeva uvid u potpune, točne, pravovremene i razumljive informacije o proračunima lokalnih jedinica (Bronić i sur., 2023). Transparentnost je važna za sve građane, jer oni su ti koji uplaćuju poreze u proračune lokalnih jedinica i koriste se njihovim uslugama. Proračunska transparentnost može potaknuti preraspodjelu i uključivost, pomoći građanima da bolje razumiju i nadziru proračune, plaćaju niže poreze i dobiju efikasnije lokalne usluge. Proračunska transparentnost jedna je od ključnih tema suvremenih istraživanja političke ekonomije i javne uprave, uz temeljnu pretpostavku da se njome osigurava odgovornost. Zahvaljujući prethodnim projektima HRZZ-a, Institut za javne financije od 2015. godišnje mjeri transparentnost proračuna svih 576 hrvatskih lokalnih jedinica. Na temelju tih istraživanja dostupni su izglasani proračuni na mrežnim stranicama hrvatskih lokalnih jedinica za provođenje ovog istraživanja o VPP-u koji su već djelomično prikupljeni. Na temelju kratkog pretraživanja slovenskih lokalnih jedinica, većinom su dostupni planovi proračuna na mrežnim stranicama tako da se nadam prikupljanju podataka za sve slovenske općine. Uz pomoć linearnih i nelinearnih panel modela analizirat će se odrednice vjerodostojnosti planiranja proračuna na lokalnim razinama u Hrvatskoj i Sloveniji. Tako bi se mogla popuniti praznina u postojećim znanjima i znanstvenoj literaturi. Svrha istraživačkog usavršavanja je istražiti ekonomske i političke odrednice VPP-a na lokalnim razinama u Hrvatskoj i Sloveniji.Organizacija-domaćin: Ekonomsko-poslovni fakultet (FEB), Sveučilište u Mariboru, Slovenija]]></summary_en></project><project>
<id>16296</id><title_hr><![CDATA[Odlazna mobilnost viših asistenata - Mateja Matišić]]></title_hr><title_en><![CDATA[]]></title_en><user_id>25282</user_id><user_firstLast_name>Mateja Matišić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBODL</proposal_type><proposal_call>2023-12</proposal_call><code>MOBODL-2023-12-3788</code><acronim><![CDATA[]]></acronim><duration>01.08.2024 - 31.07.2025</duration><status>U tijeku</status><financ_value>48.000,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Foldameri su sintetski oligomeri koji podsjećaju na strukture biopolimera, uključujući proteine i nukleinske kiseline. Njihova konceptualna sličnost s biopolimerima omogućuje im analogne primjene u području katalize, molekularnog prepoznavanja, transporta, prijenosa signala, senzora, itd. Gotovo neograničen skup građevnih blokova (monomera) omogućuje dizajn foldamera s bezbrojnim funkcijama i primjenama koje mogu i nadilaziti funkcije biopolimera. S obzirom da je funkcija molekule određena njezinom trodimenzionalnom strukturom ili konformacijom, razvijane su različite strategije za postizanje uređenih i stabilnih konformacija foldamera. Postojeće metodologije oslanjaju se na ograničenje konformacijske slobode putem nekovalentnih interakcija, najčešće vodikovih veza, ali istražen je i utjecaj torzijskog naprezanja, halogenih veza, vezanja metala i hidrofobnih interakcija.Predloženo istraživanje ima za cilj stvoriti novu klasu foldamera, sintetskih analoga polipeptida, gdje je konformacija same okosnice određena nizom atropoizomernih veza. Foldameri će biti konstruirani iz različitih akiralnih građevnih blokova sastavljenih kroz niz iterativnih koraka u kojima će stereokemija nastalih veza biti kontrolirana katalizatorom. Razvijeni originalni sintetski pristup ovakvim foldamerima, koji koristi poznate atroposelektivne metodologije u iterativnom pristupu, mogao bi se poopćiti na niz postojećih atroposelektivnih sintetskih reakcija jednostavnom prilagodbom monomera. Stoga se očekuje da će pronaći primjenu u sintezi brojnih novih foldamera s atropoizomernom okosnicom. Svojstva atropizomernih foldamera trenutno su nepoznata, a predložena studija će pružiti prvu priliku da se ispita njihovo ponašanje. Izlaganje atropoizomernih foldamera različitim temperaturama može utjecati na njihovu konformaciju, što pruža mogućnost dizajna novih sintetičkih receptora. Ovo usavršavanje će poslijedoktorandici omogućiti upoznavanje s kemijom foldamera te principima određivanja konformacije kod ovih spojeva. S obzirom da postoje određene kompatibilnosti između istraživanja koje se provode u organizaciji-domaćinu i organizaciji-prijavitelju, očekuje se nastavak suradnje s mentorom domaćinom, koja bi mogla izroditi prijavom zajedničkih znanstvenih projekata na međunarodne natječaje, a time i zajedničkih publikacija. Nadalje, ovim usavršavanjem otvorit će se vrata daljnjoj suradnji s računalnim kemičarima, ali i drugim znanstvenicima u području kemije foldamera.Organizacija-domaćin: Queen-s University Belfast, Ujedinjena Kraljevina]]></summary_en></project><project>
<id>16297</id><title_hr><![CDATA[Odlazna mobilnost viših asistenata - Marko Šoštar]]></title_hr><title_en><![CDATA[]]></title_en><user_id>12533</user_id><user_firstLast_name>Marko Šoštar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBODL</proposal_type><proposal_call>2023-12</proposal_call><code>MOBODL-2023-12-7069</code><acronim><![CDATA[]]></acronim><duration>01.09.2024 - 31.08.2025</duration><status>U tijeku</status><financ_value>48.000,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[U okviru inovativne inicijative unutar računalne biologije, novi istraživački projekt spaja svjetove strojnog učenja s tehnikama biološkog modeliranja. Ovaj projekt predstavlja korak ka integraciji dviju naprednih računalnih tehnika: Procesnog modeliranja (eng. Process based modeling - PBM) i Vjerojatnosnih bezokolinskih gramatika (eng. Probabilistic Context-Free Grammars - PCFG), s fokusom na dinamični svijet proteina Rac1.Protein Rac1 kritična je komponenta u staničnoj signalizaciji i regulaciji. Razumijevanje njegove dinamike ima veliki značaj u istraživanju raka, imunologije, te stanične i molekularne biologije. Predloženi projekt usmjeren je na stvaranje računalnih modela dinamike Rac1, pridonoseći dubljem razumijevanju njegove uloge u biološkim procesima. PBM nalikuje stvaranju detaljnog nacrta, u kojem su pažljivo mapirane poznate interakcije unutar biološkog sustava. Slično kao što arhitekt detaljno planira gradnju velike zgrade, PBM precizno mapira specifične puteve i mehanizme unutar bioloških struktura, stvarajući jasnu sliku svake komponente i njene uloge.S druge strane, PCFG donosi element vjerojatnosnog načina istraživanja i prilagodljivosti svojstvene strojnom učenju. Vjerojatnosne gramatike slične su kreativnom umjetniku, koji eksperimentira s različitim obrascima, vođen intuitivnim razumijevanjem informacija iz okoline. Ovaj aspekt istraživanja omogućuje otkrivanje novih obrazaca i uvida u biološke procese. Fuzija preciznosti metode PBM i kreativnosti algoritama PCFG čini suštinu ovog istraživanja, kojim se nastoji produbiti razumijevanje dinamike Rac1, ali i rasvijetliti šire aspekte biološke kompleksnosti. Integracijom ovih metodologija, istraživanje nadilazi konvencionalne tehnike modeliranja, nudeći dinamičniju i sveobuhvatniju perspektivu za promatranje i predviđanje ponašanja složenih sustava.Organizacija-domaćin: Institut Jožef Štefan, Slovenija]]></summary_en></project><project>
<id>16298</id><title_hr><![CDATA[Odlazna mobilnost viših asistenata - Martina Pezer]]></title_hr><title_en><![CDATA[]]></title_en><user_id>21291</user_id><user_firstLast_name>Martina Pezer</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBODL</proposal_type><proposal_call>2023-12</proposal_call><code>MOBODL-2023-12-7190</code><acronim><![CDATA[]]></acronim><duration>18.11.2024 - 17.11.2025</duration><status>U tijeku</status><financ_value>48.000,00 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, </scie_field_hr><scie_field_en>Economy, </scie_field_en><institution_hr><![CDATA[Institut za javne financije]]></institution_hr><institution_en><![CDATA[Institute of Public Finance]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Planirano znanstveno-istraživačko usavršavanje u Luxembourg Institute of Socio-Economic Research (LISER) bavi se suvremenim problemima blagostanja društava. Dok su se globalne dohodovne i imovinske nejednakosti među zemljama smanjile u posljednja dva desetljeća, nejednakost je porasla unutar većine zemalja. Pandemija bolesti COVID-19 zadala je težak udarac svjetskim gospodarstvima, što je 2020. rezultiralo najvećim povećanjem globalne nejednakosti od 1990. Ruska invazija Ukrajine pogoršala je ionako izazovnu situaciju podižući cijene energije i hrane. lako su globalne cijene hrane i energije snižene sa svojih najviših razina sredinom 2022., one su i dalje visoke u mnogim zemljama, nerazmjerno utječući na siromašnija kućanstva.Svrha istraživanja tijekom usavršavanja u LISER-u je proučiti distributivne učinke inflacije na blagostanje. Provest će se analiza nejednakosti dohotka i potrošnje u suvremenom okruženju rastućih troškova života uz pomoć pariteta kupovne moći i ljestvica ekvivalencije prilagođenima za blagostanje. Komparativna analiza za članice EU-a će pružiti metodološki i empirijski doprinos poboljšanjem procjene utjecaja povećanja cijena na blagostanje. Istraživanje će se temeljiti na konceptualnom okviru kojeg je u LISER-u razvila dr. sc. Sologon sa suradnicima. Tijekom usavršavanja razvit će se i primijeniti mikrosimulacijske i mikroekonometrijske tehnike te koristiti anketni podatci. Pružit će se smjernice za oblikovanje javnih politika, s ciljem stvaranja boljih socijalnih sigurnosnih mreža i poboljšanog životnog standarda za najpotrebitije u EU-u.Organizacija-domaćin: Luxembourg Institute of Socio-Economic Research (LISER), Luksemburg]]></summary_en></project><project>
<id>16301</id><title_hr><![CDATA[Dolazna mobilnost viših asistenata - Vjeran Pavlakovic]]></title_hr><title_en><![CDATA[]]></title_en><user_id>2671</user_id><user_firstLast_name>Vjeran Pavlakovic</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOL</proposal_type><proposal_call>2023-12</proposal_call><code>MOBDOL-2023-12-3186</code><acronim><![CDATA[]]></acronim><duration>02.06.2024 - 01.05.2026</duration><status>U tijeku</status><financ_value>83.375,00 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Povijest, </scie_field_hr><scie_field_en>History, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Filozofski fakultet u Rijeci]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Učenje o prošlosti često se povezuje s razvojem demokracije i borbom protiv opasnih polarizacija i drugih negativnih pojava u društvu. Mladi uče o prošlosti na mnogo različitih načina, a obrazovanje o povijesti u školi je vjerojatno jedno od najvažnijih. To je djelomično zato što gotovo svi mladi u većini društava pohađaju povijesne lekcije, a djelomično zato što povijesno obrazovanje ima epistemički autoritet. Ipak, povijest u školi je tek jedan od izvora znanja mladih o prošlosti. Popularna kultura (kroz film, glazbu i uličnu umjetnost, između ostalih) je važan i nedovoljno istražen izvor znanja i arena za pregovaranje o značenjima za mlade. Poznato je da, posebno u post-konfliktnim društvima, prepreke pomirbi mogu nastati kada inačice prošlosti dostupne u učionici stoje u suprotnosti s inačicama prošlosti predstavljenim izvan učionice. Na temelju toga želimo utvrditi kako mladi u Hrvatskoj, Sloveniji, i Srbiji čitaju, razumiju i (iznova) pregovaraju značenja o prošlosti koja se prenose kroz ove različite medije. Kako bi to učinili, razmatramo i odnose između inačica prošlosti pronađenih u formalnom obrazovanju i onih prisutnih u popularnoj kulturi (murali, filmovi i popularna glazba) u nekoliko bivših jugoslavenskih zemalja (Hrvatska, Slovenija, i Srbija).Gostujući istraživač: dr. sc. Rodoljub Jovanović]]></summary_en></project><project>
<id>16302</id><title_hr><![CDATA[Odlazna mobilnost viših asistenata - Jakov Žižić]]></title_hr><title_en><![CDATA[]]></title_en><user_id>867609</user_id><user_firstLast_name>Jakov Žižić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBODL</proposal_type><proposal_call>2023-12</proposal_call><code>MOBODL-2023-12-5430</code><acronim><![CDATA[]]></acronim><duration>15.09.2024 - 14.09.2025</duration><status>U tijeku</status><financ_value>48.000,00 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Politologija, </scie_field_hr><scie_field_en>Political Science, </scie_field_en><institution_hr><![CDATA[Hrvatsko katoličko sveučilište, Zagreb]]></institution_hr><institution_en><![CDATA[Catholic University of Croatia]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Demokršćanski akteri i njihove političke ideje imali su ključni utjecaj u oblikovanju političkih institucija u poslijeratnoj Europi. Cilj ovog znanstveno-istraživačkog usavršavanja je utvrditi i objasniti utjecaj demokršćanskog modela demokracije na politički sustav Europske unije te nastanak i razvoj ustavnog sudstva u državama članicama Europske unije. Također će se istražiti relevantnost demokršćanskog modela demokracije u političkim, ekonomskim i kulturnim okolnostima kasnog modernizma.Organizacija-domaćin: AMBIS University, Prag, Češka Republika]]></summary_en></project><project>
<id>16305</id><title_hr><![CDATA[Odlazna mobilnost viših asistenata - Matea Žilak]]></title_hr><title_en><![CDATA[]]></title_en><user_id>25471</user_id><user_firstLast_name>Matea Žilak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBODL</proposal_type><proposal_call>2023-12</proposal_call><code>MOBODL-2023-12-2055</code><acronim><![CDATA[]]></acronim><duration>01.10.2024 - 30.09.2025</duration><status>U tijeku</status><financ_value>48.000,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Područje istraživanja predloženog znanstvenog usavršavanja jest pristupačnost tehnologija koje nude mogućnost uranjanja korisnika u virtualni svijet, a koje su ključne za metasvijet (engl. metaverse). Budući da je riječ o novom konceptu koji bi mogao utjecati na sve aspekte ljudskog života, važno je osigurati da njegovo korištenje bude pristupačno svim korisnicima, bez obzira na dob i sposobnosti, uključujući osobe starije životne dobi i osobe s invaliditetom. Stoga će se tijekom usavršavanja provesti istraživanje potreba i ograničenja korisnika kako bi se definirali načini prilagodbe rješenja u metasvijetu specifičnim zahtjevima pojedinog korisnika. Pri tome će se u obzir uzeti specifičnosti tehnologije poput 3D okruženja i virtualne stvarnosti te metasvijeta u kojem korisnici u stvarnom vremenu komuniciraju s drugim korisnicima (avatarima) i imaju mogućnost interakcije s virtualnim sadržajem. Temeljem istraživanja prilagodit će se rješenje sveučilišnog muzeja Telecommunications History Museum Vicente Miralles Segarra u virtualnoj stvarnosti za korištenje u metasvijetu za različite platforme čime će se korisnicima rješenja omogućiti novo iskustvo posjeta muzeju.Predloženo znanstveno-istraživačko usavršavanje omogućit će istraživačici detaljnu analizu pristupačnosti rješenja u metasvijetu s obzirom na korištenu tehnologiju, identificiranje ključnih izazova s kojima se suočavaju osobe s različitim teškoćama u njihovoj upotrebi, definiranje značajki pristupačnosti i potrebnih prilagodbi rješenja pojedinom korisniku, razvoj metodologije za evaluaciju pristupačnosti rješenja u metasvijetu te razvoj smjernica za poboljšanje pristupačnosti takvih rješenja. Razumijevanje stvarnih potreba korisnika, čiji su zahtjevi često heterogeni i konfliktni, omogućit će doprinos daljnjem razvoju smjernica i standarda pristupačnosti za rješenja u metasvijetu, i time pridonijeti široj uporabi tehnologija metasvijeta te digitalnoj i društvenoj uključenosti osoba s invaliditetom.Organizacija-domaćin: Universitat Politécnica de Valéncia, Španjolska]]></summary_en></project><project>
<id>16308</id><title_hr><![CDATA[Odlazna mobilnost viših asistenata - Jan Homolak]]></title_hr><title_en><![CDATA[]]></title_en><user_id>27148</user_id><user_firstLast_name>Jan Homolak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBODL</proposal_type><proposal_call>2023-12</proposal_call><code>MOBODL-2023-12-2591</code><acronim><![CDATA[]]></acronim><duration>02.06.2024 - 01.05.2026</duration><status>U tijeku</status><financ_value>92.000,00 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Novi dokazi upućuju na moguću važnu biološku ulogu mikroorganizama koji obitavaju u probavnom sustavu (mikrobiote) na razvoj i progresiju bolesti. Sve više istraživanja pokazuje da bi značaj mikrobiote mogao biti posebno izražen kod bolesti središnjeg živčanog sustava. Osim toga, lijekovi koji djeluju na središnji živčani sustav pokazuju neočekivano izražen učinak na mikroorganizme u crijevu u odnosu na ostale lijekove za liječenje različitih sistemskih bolesti, što ukazuje na mogući značaj mikrobiote i u odgovoru na terapiju za liječenje ovih poremećaja. Međutim, biološka pozadina uloge mikrobiote u razvoju bolesti središnjeg živčanog sustava i interakcija mikroorganizama iz probavnog sustava s lijekovima koji djeluju na središnji živčani sustav još uvijek nije istražena. Cilj predloženog znanstveno-istraživačkog usavršavanja je razjasniti ulogu mikroorganizama u probavnom sustavu u razvoju poremećaja središnjeg živčanog sustava i odgovoru na terapiju lijekovima s djelovanjem na središnji živčani sustav korištenjem sofisticiranih metoda koje omogućavaju analizu velikog broja interakcija lijekova s brojnim mikroorganizmima u izolaciji, u umjetno stvorenim zajednicama mikroorganizama koje oponašaju one u probavnom sustavu te u zajednicama mikroorganizama izdvojenih iz probavnog sustava pacijenata in vitro i in vivo. Rezultati predloženog istraživanja mogli bi značajno doprinijeti razumijevanju bolesti poput depresije, a razjašnjavanje interakcije lijekova i mikroorganizama moglo bi stvoriti temelje za personaliziranu terapiju i razvoj novih terapijskih strategija.Organizacija-domaćin: Eberhard Karls Sveučilište u Tübingenu, Njemačka]]></summary_en></project><project>
<id>16310</id><title_hr><![CDATA[Odlazna mobilnost viših asistenata - Krešimir Kušić]]></title_hr><title_en><![CDATA[]]></title_en><user_id>25509</user_id><user_firstLast_name>Krešimir Kušić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBODL</proposal_type><proposal_call>2023-12</proposal_call><code>MOBODL-2023-12-5261</code><acronim><![CDATA[]]></acronim><duration>01.11.2024 - 30.04.2026</duration><status>U tijeku</status><financ_value>96.000,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Tehnologija prometa i transport, </scie_field_hr><scie_field_en>Transport technology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet prometnih znanosti]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Transport and Traffic Sciences]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Sve veća dostupnost prometnih podataka u stvarnom vremenu, uključujući podatke iz vozila, omogućit će procjenu detaljnog stanja prometnih uvjeta na cestovnoj mreži u stvarnom vremenu. Sve veća razine asistencije i upravljanja nad pojedinačnim vozilima predstavlja priliku za razvoj naprednih adaptivnih sustava upravljanja prometom zasnovanih na umjetnoj inteligenciji. Istraživački projekt usmjeren je na izradu decentraliziranog adaptivnog višeagentnog regulatora promjenjivoga ograničenja brzina na autocestama u kontekstu pametnih vozila. Adaptivno donošenje upravljačkih odluka i kontinuirano poboljšanje upravljačkog zakona osigurat će se naprednim učećim algoritmima zasnovanim na dubokom potpornom učenju i višeagentnim sustavima. Istraživanje će se također baviti trenutnim izazovima koji se postavljaju na direktnu implementaciju učećih regulatora u fizički prometni sustav. Ti izazovi uključuju sporiju dinamiku stvarnih procesa prometa u usporedbi s računalnim simulacijama i ograničenost dostupnih podataka zbog sigurnosnih ograničenja na prometni sustav te su posljedično generirani podaci daleko ispod zahtjeva koji se obično postavljaju na učeće algoritme. U projektu će se istražiti potencijal tehnologije mikrosimulacijskog digitalnog blizanaca fizičke autoceste za prevladavanje spomenutih izazova, smanjujući jaz između simulacija i stvarnih prometnih scenarija za učinkovitiju i direktniju obuku adaptivnih upravljačkih prometnih sustava na stvarnim prometnim procesima. Generalno, rezultati će pružiti dokaze o tome u kojoj mjeri integracija tehnologije digitalnog blizanca autoceste i adaptivnog upravljačkog sustava može približiti proces treninga i evaluacije učećih regulatora promjenjivoga ograničenja brzine na kritičnoj prometnoj infrastrukturi u stvarnom vremenu. Ovo će pružiti dodatne detalje o dizajnu predložene interakcije između učećeg upravljačkog algoritma i modela digitalnog blizanca autoceste. Razvijen višeagentni sustav zasnovan na tehnikama dubokog učenja kao nova paradigma za dinamičku kontinuiranu prostorno-vremensku prilagodbu brzine prometnog toka kroz model simultanog upravljanja brzinama konvencionalnih i autonomnih vozila pružit će temeljne dokaze o efikasnosti primijenjene tehnologije u kontekstu mikro-makro hijerarhijskog koncepta upravljanja brzinama u kontekstu nelinearnosti i nestacionarnosti procesa na autocestama. Također predloženi koncept hijerarhijskog upravljanja brzinama dati će važna saznanja o smjernicama za dizajn tranzicijskih modela upravljanja brzinama vozila za prijelazno razdoblje s konvencionalnih na autonomna vozila te prikladnih tehnologija za njihovu izvedbu. Učinak za društvo i gospodarstvo se očituje u sljedećem. Dobiveni rezultati će biti od praktične važnosti jer mogu signalizirati vlastima (operaterima na autocestama) i industriji prioritetne smjernice razvoja opreme i softverskih rješenja za upravljačke prometne centre te tehnološku nadogradnju cestovne i popratne infrastrukture za potrebe upravljanja brzinama na autocestama u kontekstu sve veće automatizacije vozila. Generalno, predloženi model adaptivnog sustava upravljanja brzinama zasnovan na platformi digitalnog blizanca može poslužiti kao pomoćni sustav (asistent) u donošenju odluka operativnog osoblja u upravljačkim prometnim centrima.Organizacija-domaćin: Trinity College Dublin, Irska]]></summary_en></project><project>
<id>16311</id><title_hr><![CDATA[Odlazna mobilnost viših asistenata - Jerko Hrabar]]></title_hr><title_en><![CDATA[]]></title_en><user_id>13683</user_id><user_firstLast_name>Jerko Hrabar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBODL</proposal_type><proposal_call>2023-12</proposal_call><code>MOBODL-2023-12-7168</code><acronim><![CDATA[]]></acronim><duration>14.10.2024 - 13.10.2025</duration><status>U tijeku</status><financ_value>48.000,00 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Institut za oceanografiju i ribarstvo]]></institution_hr><institution_en><![CDATA[Institute of Oceanography and Fisheries]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Morska riba i ostali plodovi mora općenito se smatraju važnim izvorom nutritivno vrijednih spojeva, poput omega-3 masnih kiselina, koji mogu pomoći u prevenciji bolesti povezanih s modernim načinom života. Zbog promjena u prehrambenim navikama, u posljednjim desetljećima bilježi se značajan porast potražnje za visokokvalitetnim i zdravstveno ispravnim proizvodima ribarstva. U tom smislu, akvakultura je alternativa tradicionalnom ribolovu u zadovoljavanju tržišnih potreba te ujedno predstavlja sektor proizvodnje hrane s najbržim rastom. Da bi mogla zadovoljiti sve veće potrebe tržišta, suvremena akvakultura mora biti ekološki održiva, što je moguće ostvariti uvođenjem novih izvora hrane i mjera kontrole zaraznih bolesti, poput učinkovitih cjepiva i probiotika u svrhu prevencije. Među zaraznim bolestima kod uzgojenih riba od velikog je značaja virusna bolest koja uzrokuje propadanje živčanog sustava (virusna živčana nektoza, VNN), čija pojava uzrokuje visoku smrtnost zaražene ribe i značajnu ekonomsku štetu za uzgajivače. Trenutno ne postoji učinkovito cjepivo ni terapijske mjere protiv ove bolesti, što je bitna prepreka ostvarenju cilja ekološke i ekonomske održivosti akvakulture Stoga je cilj ovog usavršavanja ispitati učinkovitost novog cjepiva protiv uzročnika ove bolesti za primjenu u uzgoju lubina kao jedne od najznačajnijih vrsta hrvatske i europske akvakulture. Ispitivanje učinkovitosti će se temeljiti na stopi preživljenja cijepljene i pokusno zaražene ribe te mjerenju imunosnog odgovora izazvanog cjepivom u svrhu određivanja intenziteta i dugotrajnosti zaštite. Pozitivni rezultati ovog usavršavanja koje se oslanja na aktivnosti interdisciplinarnog i kompetitivnog projekta Cure4Aqua, čiji značaj je prepoznala Europska Unija, ostvarit će veliki potencijal za direktnu primjenu na uzgajalištima. Imajući u vidu da se bolest VNN sve češće bilježi na uzgajalištima diljem Europe, razvoj učinkovitog cjepiva će direktno i u velikoj mjeri doprinijeti razvoju održive akvakulture.Organizacija-domaćin: Politécnico de Leiria, Portugal]]></summary_en></project><project>
<id>16312</id><title_hr><![CDATA[Odlazna mobilnost viših asistenata - Mario Lovrić]]></title_hr><title_en><![CDATA[]]></title_en><user_id>27330</user_id><user_firstLast_name>Mario Lovrić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBODL</proposal_type><proposal_call>2023-12</proposal_call><code>MOBODL-2023-12-5502</code><acronim><![CDATA[]]></acronim><duration>19.08.2024 - 18.08.2025</duration><status>U tijeku</status><financ_value>48.000,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut za antropologiju]]></institution_hr><institution_en><![CDATA[Institute for Anthropological Research]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Trudnoća, porođaj i prvi mjeseci života ključni su u razvoju bolesti već od rane dječje dobi. Tijekom trudnoće i rane dječje dobi, majka i dijete izloženi su istim hranjivim tvarima i okolišnom unosu kemijskih spojeva (kasnije metabolita). Nadalje, neki metaboliti su i posljedica enzimatskih biokemijskih pretvorbi koje proizlaze iz genoma domaćina ili crijevnog mikrobioma, koji se također dijeli između majke i djeteta. Metabolomika nudi sveobuhvatan način za identificiranje i mjerenje metabolita u biološkom sustavu, što je tehnika poželjna za identifikaciju fenotipova te slijedi genomiku, transkriptomiku i proteomiku u nizu. Metaboliti, koji uključuju molekule poput lipida, šećera, nukleotida i aminokiselina, krajnji su proizvodi i međuprodukti metaboličkih procesa u organizmu. Stoga, varijacije na ovoj razini mogu signalizirati potencijalni napredak bolesti prije kliničke prezentacije istoga biti potencijalni biomarker, čineći metabolomiku vitalnim alatom za rano otkrivanje bolesti. Nadalje, metabolomika predstavlja mehanistički sloj informacija za razumijevanje načina djelovanja izloženosti poput prehrane, vježbanja itd. na napredovanje bolesti. Metabolički prijenos s majke na dijete istraživali su u prethodnim radovima ove grupe koristeći linearnu korelacijsku analizu. Međutim to su samo linearni odnosi te zasad još nije poznato što i kako se prenosi od metabolita s majke na dijete niti kojim metodama to odrediti.U ovom radu nam je cilj istražiti kako vertikalni prijenos metabolita s majke na dijete utječe na razvoj bolesti u ranoj dječjoj dobi prepoznavanjem obrazaca pomoću nelinearnog strojnog učenja metodama kao što su duboke neuronske mreže, algoritam nasumičnih šuma i sličnih . Predlažemo novi pristup za modeliranje vertikalnog prijenosa na način vođen podacima bez prethodnih hipoteza, koristeći strojno učenje na objašnjiv način, posebice u kliničkom smislu.Organizacija-domaćin: Department of Food Science (FOOD), University of Copenhagen, Danska]]></summary_en></project><project>
<id>16315</id><title_hr><![CDATA[Dolazna mobilnost viših asistenata - Anamarija Kurilić]]></title_hr><title_en><![CDATA[]]></title_en><user_id>254</user_id><user_firstLast_name>Anamarija Kurilić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOL</proposal_type><proposal_call>2023-12</proposal_call><code>MOBDOL-2023-12-2741</code><acronim><![CDATA[]]></acronim><duration>01.06.2024 - 30.04.2026</duration><status>U tijeku</status><financ_value>83.375,00 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Povijest, </scie_field_hr><scie_field_en>History, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zadru]]></institution_hr><institution_en><![CDATA[University of Zadar]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Znanstveno usavršavanje kandidata bazira se na analizi epigrafske i arheološke baštine rimskog doba regija Japodije i Liburnije, smještenih u sjeverozapadnom dijelu antičke provincije Dalmacije, s posebnim fokusom na tipologiju nadgrobnih spomenika i njihovih kulturnih vrijednosti. Usavršavanje je omogućeno zahvaljujući uključivanju u istraživački projekt HRZZ-a, STTL (Sit Tibi Terra Levis: Formule i fraze s nadgrobnih spomenika antičke Liburnije i Japodije) koji sljedeće četiri godine vodi profesorica A. Kurilić sa Sveučilišta u Zadru. Kao dolazni vanjski istraživač, kandidat će imati priliku osobno pratiti sve faze projekta, koje uključuju prikupljanje i proučavanje nadgrobnih epigrafskih spomenika rimskog doba na navedenom području, njihovu organizaciju u novu bazu podataka, koja će biti dostupna za online konzultacije i analizu njihovog izvornog podrijetla kroz terenska rekognosciranja, arheološka istraživanja i georeferenciranje (konkretno, projekt će uključivati snažnu sinergiju između Odjela za povijest i Odjela za geografiju Sveučilišta u Zadru). Mladi istraživač će pak podijeliti sve svoje vještine u području rimske pogrebne arheologije stečene tijekom doktorskog studija na Sveučilištu Sapienza u Rimu. Njegov će doprinos biti postavljanje specifične rasprave o korelaciji između svih posebnosti epigrafskih spomenika i nekih preciznih pogrebnih tipologija prepoznatljivih kroz arheološku analizu, istražujući sve moguće aspekte na povijesnoj i društvenoj razini. MOBDOL Program usavršavanja imat će značajan utjecaj na karijeru kandidata i na internacionalizaciju Sveučilišta u Zadru, otvarajući važne buduće suradnje u području proučavanja i valorizacije nacionalne arheološke baštine.Gostujući istraživač: dr. sc. Matteo Pola]]></summary_en></project><project>
<id>16317</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Silvia Morović]]></title_hr><title_en><![CDATA[]]></title_en><user_id>29635</user_id><user_firstLast_name>Silvia Morović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-8328</code><acronim><![CDATA[]]></acronim><duration>01.06.2024 - 15.11.2024</duration><status>U tijeku</status><financ_value>14.280,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Kemijsko inženjerstvo, </scie_field_hr><scie_field_en>Chemical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet kemijskog inženjerstva i tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Chemical Engineering and Technology]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Brza urbanizacija i sve veća potražnja za vodom zahtijevaju velika ulaganja u tehnologije koje omogućuju učinkovitu i ekološki održivu obradu voda te tehnologije koje zadovoljavaju najstrože standarde o kvaliteti vode u svrhu ponovne upotrebe. Međutim, još uvijek postoje veliki izazovi usko povezani s pojavom novih organskih onečišćivala i nusprodukata dezinfekcije voda [8-11]. Glavni cilj ovog znanstveno-istraživačkog usavršavanja je optimizacija i evaluacija naprednog membranskog procesa obrade vode nakon biološke obrade otpadne vode s ciljem povećanja učinkovitosti uklanjanja farmaceutika i dezinfekcijskih nusprodukata po principu „zero waste“ koncepta i načelima cirkularne ekonomije. Pomičući granice konvencionalnih pristupa, kombiniranim znanjem i idejama stručnog tima organizacije-domaćina i organizacije-prijavitelja istražit će se i ponuditi praktična rješenja za izazove s kojima se suočava industrija pročišćavanja vode kao i cjelokupna zajednica. Također, razvojem i optimizacijom procesa, uz korištenje najsuvremenijih metoda, tehnika i instrumentacije, očekuje se visokokvalitetna publikacija u međunarodnom znanstvenom časopisu kao i sudjelovanje na konferencijama relevantnim za vodu i održivi razvoj.Organizacija-domaćin: Aarhus University]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16318</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Suzana Inkret]]></title_hr><title_en><![CDATA[]]></title_en><user_id>865265</user_id><user_firstLast_name>Suzana Inkret</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-4472</code><acronim><![CDATA[]]></acronim><duration>02.04.2024 - 28.06.2024</duration><status>U tijeku</status><financ_value>7.480,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Povećana učestalost ozljeda i obojenja čvrstih tkiva (kostiju i zuba), uzrokovana modernim načinom života i starenjem populacije, motivira uspostavu novih, učinkovitijih metoda liječenja. U velikom broju slučajeva, najbolji ili čak jedini mogući pristup je operativna ugradnja implantata koji zamjenjuje oboljelo ili ozlijeđeno tkivo. Usprkos napretku operacijskih tehnika, najveći problem takvih implantacija ostaju bakterijske infekcije. Rješenje problema su antimikrobni materijali za izradu ili prevlačenje površine implantata.U tu svrhu istražujemo biomimetske prevlake za površine titanijevih implantata građene od kompozita kalcijevih fosfata i srebrnih nanočestica različite površinske modifikacije s ili bez biomakromolekula (albumin, kitozan).U sklopu usavršavanja na INAM-u i IKTS-u planirana je detaljna fizikalno-kemijska karakterizacijapripravljenih prevlaka naprednim metodama uključujući pretražnu elektronsku mikroskopiju (SEM), mikroskopiju atomskih sila (AFM), Ramanovu spektroskopiju, energetski disperzivnu spektroskopiju (EDS), elektronsku difrakciju povratnim raspršenjem elektrona (EBSD), elipsometriju, mjerenje kontaktnog kuta te određivanje specifične površinske energije.Rezultati navedenog usavršavanja dat će uvid u metodologiju biomimetske pripreme prevlaka na titanijevim površinama s regenerativnim i antibakterijskim svojstvima koje bi potencijalno imale veliku primjenu u implantologiji. Usavršavanje će također omogućiti proširenje postojeće suradnje istraživačkih grupa institucija prijavitelja i domaćina.Organizacija-domaćin: Fraunhofer-Institut fur Keramische Technologien und Systeme, IKTS / Innovations Institut fur Nanotechnologie und korrelative Mikroskopie, INAM]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16319</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Dina Levačić]]></title_hr><title_en><![CDATA[]]></title_en><user_id>867619</user_id><user_firstLast_name>Dina Levačić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-1291</code><acronim><![CDATA[]]></acronim><duration>16.03.2024 - 20.04.2024</duration><status>U tijeku</status><financ_value>3.060,00 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Clinical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Split School of Medicine]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Plivanje u hladnom je sve popularniji način rekreacije u cijelom svijetu. Ipak, jedna od opasnosti koja dolazi s tim je hipotermija. Hipotermija ima izravne zdravstvene rizike, ali i neke neizravne. Jedan od neizravnih rizika su smanjene vozačke sposobnosti. Mnogobrojne osobe koje prakticiraju plivanje u hladnom, poslije istog, upravljaju automobilom nesvjesni potencijalnog rizika. Hipotermija može djelovati na smanjenje kognitivnih i motoričkih sposobnosti što povećava rizik kod sudjelovanja u prometu. Cilj istraživanja na kojem asistentica sudjeluje je dobiti podatke koliko su smanjene vozačke sposobnosti nakon pothlađivanja, kao i koji je najefikasniji način zagrijavanja nakon istog kako bi se smanjili rizični faktori.Sudjelovanje u ovom istraživanju omogućit će mladom istraživaču koji sudjeluje usvajanje novih znanja i vještina. Također omogućit će i iskustvo rada u međunarodnom timu koji je jedan od najboljih u svijetu u svom području, kao i ostvarivanje i jačanje veza za buduće suradnje.Organizacija-domaćin: University of Portsmouth]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16320</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Bojana Barać]]></title_hr><title_en><![CDATA[]]></title_en><user_id>865034</user_id><user_firstLast_name>Bojana Barać</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-4271</code><acronim><![CDATA[]]></acronim><duration>05.06.2024 - 05.12.2024</duration><status>U tijeku</status><financ_value>15.640,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[U trenucima događaja male vjerojatnosti, a visokog utjecaja na građane, poput poplava, potresa, oluja, požara, prekid energije stvara dodatan stres i često usporava povratak života nazad u normalno stanje. Istraživanje stoga cilja na više aspekata ovog tehničkog, ekonomskog, ali i socijalno osjetljivog problema: 1) stvaranje modela upravljanja distribuiranim izvorima fleksibilnosti koji bi omogućili što bržu uspostavu ponovnog napajanja električnom energijom time povećavajući otpornost sustava, 2) kreiranje metrika koje bi ukazale na slabe točke postojećeg sustava i predložile planske aktivnosti kojima bi se minimizirala šteta uzrokovana prekidom napajanja uslijed malo vjerojatnih, ali visoko utjecajnih događaja.Organizacija-domaćin: University of Cyprus Department of Electrical and Computer Engineering]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16324</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Nina Girotto]]></title_hr><title_en><![CDATA[]]></title_en><user_id>855985</user_id><user_firstLast_name>Nina Girotto</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-8019</code><acronim><![CDATA[]]></acronim><duration>10.04.2024 - 08.06.2024</duration><status>U tijeku</status><financ_value>5.100,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut za fiziku]]></institution_hr><institution_en><![CDATA[Institute of Physics in Zagreb]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Velika se važnost pridaje ultrabrzim eksperimentima u fizici kondenzirane materije. Radi se o eksperimentima u kojima se kratkim laserskim pulsom, sustav dovede u stanje izvan ravnoteže pa se onda mjere njegova svojstva, koja su u pravilu bitno drugačija od svojstava u ravnoteži. Takva, neravnotežna, svojstva vrlo su zanimljiva. Na primjer, materijal može promijeniti svoju kristalnu strukturu ili može postati supravodljiv pa se potom vrlo brzo vraća u stanje ravnoteže. Takve brze promjene faze nekih materijala, korisne su za neke industrijske primjene. Sposobnost da se teorijski objasne takvi fenomeni i potpuno opiše proces relaksacije, otvaraju mogućnost ugađanja i upravljanja zanimljivim svojstvima materijala. Cilj ovog usavršavanja je unaprijediti i objediniti teorijske tehnike koje su ključne za izračune takvih faznih prijelaza.Organizacija-domaćin: Institute of Theoretical Physics and Astrophysics, Christian-Albrechts-Universitat zu Kiel]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16325</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Petra Maleš]]></title_hr><title_en><![CDATA[]]></title_en><user_id>864959</user_id><user_firstLast_name>Petra Maleš</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-9787</code><acronim><![CDATA[]]></acronim><duration>02.04.2024 - 01.07.2024</duration><status>U tijeku</status><financ_value>7.735,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Cjelovitost višestruke mijelinske membrane odgovorne za učinkovito provođenje živčanih impulsa ovisi o omjeru lipida koji je čine, kao i o njihovim interakcijama s mijelinskim bazičnim proteinom (MBP-om), intrinzično neuređenim proteinom čija je temeljna funkcija adhezija susjednih mijelinskih slojeva. Promjene u sastavu lipida i, posljedično, u funkciji MBP-a mogu rezultirati autoimunim bolestima poput multiple skleroze (MS). Budući da je kod pacijenata s MS-om nađena veća količina PE lipida koji se mogu, osim lamelarne (gel (Lo)/fluid (Lg)), naći i u nelamelarnoj inverznoj heksagonskoj fazi (Hu), pretpostavlja se postojanje veze između stvaranja vakuola uslijed demijelinizacije s povećanjem količine PE koji mogu tvoriti njima slične strukture. Unatoč mnogim provedenim biološkim studijama, pozadina demijelinizacije na molekulskoj razini je potpuno nejasna i stoga se u sklopu predloženog znanstvenog usavršavanja predlaže istraživanje svojstava modelnih mijelinskih membrana u prisustvu/odsustvu MBP-a pri različitim omjerima sastavnih lipida (fiziološki/patološki uvjeti) između lipidnih membrana i MBP-a. U svrhu detaljnije karakterizacije nastankom Hu faze, predloženim usavršavanjem će se istražiti jednokomponentne i višekomponentne modelne lipidne membrane mijelina u prisutstvu i odsutstvu mijelinskog bazičnog proteina (MBP), jednog od najvažnijih u strukturi mijelina.Za karakterizaciju fizikalno-kemijskih svojstava modelnih mijelinskih membrana koje po sastavu oponašaju fiziološke i patološke uvjete koristit će se kalorimetrijske (DSC) i spektroskopske (FTIR, UVVis, fluorimetrija, CD) tehnike. Dodatno, za istraživanje veze između povećanja količine PE lipida i demijelinizacije manifestirane pojavom vakuola će se, uz nabrojane tehnike, koristiti i tehnika raspršenja rendgenskih zraka (X-zraka) pod malim kutem (engl. small-angle X-ray scattering, SAXS). Eksperimentalne vještine kao i nova saznanja stečena radom na SAXS-u tijekom usavršavanja u laboratoriju prof. dr. techn. Pabsta na Institutu za molekularne bioznanosti Sveučilišta u Grazu u Austriji potaknut će daljnja istraživanja biološki važnih procesa unutar membranskih sustava karakterističnih kod autoimunih bolesti te poslužiti za njihovo razumijevanje na molekularnoj razini.Organizacija-domaćin: Institut für Molekulare Biowissenschaften, Universität Graz]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16326</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Robert Kolman]]></title_hr><title_en><![CDATA[]]></title_en><user_id>865075</user_id><user_firstLast_name>Robert Kolman</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-2199</code><acronim><![CDATA[]]></acronim><duration>29.04.2024 - 28.07.2024</duration><status>U tijeku</status><financ_value>7.735,00 eur</financ_value><scie_area_hr>Interdisciplinarno područje znanosti</scie_area_hr><scie_area_en>Interdisciplinary scientific area</scie_area_en><scie_field_hr>Biotehnologija u biomedicini, </scie_field_hr><scie_field_en>Biotechnology in Biomedicine, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Fakultet biotehnologije i razvoja lijekova]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Biotechnology and Drug Development]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Znanstveno-istraživačko usavršavanje usmjereno je na razumijevanje kako proupalni citokin interleukin-1 alfa utječe na ponašanje i razvoj megakariocita, specifičnih stanica koštane srži iz kojih nastaju krvne pločice ili trombociti. Konkretno, jedan od ciljeva je saznati zašto taj citokin izaziva češću pojavu fenomena emperipoleze u megakariocitima i kako to utječe na njihovu funkciju. Emperipoleza je pojava kod koje se jedna vrsta stanica fizički nalazi unutar druge stanice, a pritom su obje žive i funkcionalne. U ovom slučaju, unutar megakariocita nalazi se jedna vrsta bijelih krvnih stanica koji se zovu neutrofili. Korištenjem metodologije koja nam omogućava identifikaciju svih proteina (proteoma) koji se stvaraju u mišjim megakariocitima u odgovoru na prisutnost interleukin-1 alfa, cilj nam je otkriti kako taj proupalni citokin mijenja ponašanje megakariocita na molekularnoj razini, s potencijalnim implikacijama za razumijevanje razvoja i funkcije ove vrste stanica u stanjima povezanim s upalom.Organizacija-domaćin: Medicinski istraživački centar, Sveučilišna bolnica Essen]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16327</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Filip Zorić]]></title_hr><title_en><![CDATA[]]></title_en><user_id>856276</user_id><user_firstLast_name>Filip Zorić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-8299</code><acronim><![CDATA[]]></acronim><duration>26.06.2024 - 02.08.2024</duration><status>U tijeku</status><financ_value>3.230,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Predloženo znanstveno-istraživačko usavršavanje temelji se na razvoju metoda za poboljšanje situacijske prisutnosti operatera zračnih manipulatora pomoću umjetne inteligencije. Primaran cilj je ispitati na koji način detektirati i prenijeti operateru bitnu informaciju sa sustava zračnog manipulatora. Dugoročni cilj je proširiti postojeći sustav upravljanja zračnim manipulatorima pomoću pokreta tijela operatera kako bi se omogućile intuitivne povratne informacije samom operateru. Kako je organizacija domaćin jedna od vodećih svjetskih institucija za istraživanje sustava zračnih manipulatora u interakciji s okolinom, idealno je navedeno istraživanje raditi s istom. Potreba za ovakvim rješenjima postoji i bit će sve veća. Posebice uzme li se u obzir brzina tehnološkog napretka kao i činjenica da će se tehnologije virtualne i proširene stvarnosti sve češće koristiti za potrebe daljinskog upravljanja odnosno teleoperacije strojevima.Organizacija-domaćin: University of Twente, Nizozemska]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16329</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Nikola Čudina]]></title_hr><title_en><![CDATA[]]></title_en><user_id>867613</user_id><user_firstLast_name>Nikola Čudina</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-3451</code><acronim><![CDATA[]]></acronim><duration>01.06.2024 - 02.07.2024</duration><status>U tijeku</status><financ_value>2.720,00 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Veterinarska medicina, </scie_field_hr><scie_field_en>Veterinary medicine, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Veterinarski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Veterinary Medicine]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[U medicini je važno pravilno koristiti antimikrobne lijekove, a to uključuje određivanje točne doze za svakog pacijenta. Da bismo to postigli, trebamo imati informacije o tome kako lijek djeluje u tijelu (farmakokinetika) i koji je učinak lijeka (farmakodinamika). U veterinarskoj medicini, gdje se liječe različite vrste životinja, istraživanja se često usredotočuju na razlike među vrstama i pasminama, za razliku od ljudske medicine gdje se fokusira na razlike među pojedincima. Jedan od izazova u određivanju doza je činjenica da jednostavno uzimanje u obzir tjelesne mase životinje nije dovoljno precizno. Velike životinje imaju manju površinu tijela u usporedbi s masom, a njihove fiziološke funkcije, uključujući metabolizam, obično su sporije nego kod manjih životinja. Zbog toga, doze lijekova po kilogramu tjelesne mase često su manje u većih životinja. Ispravna doza antibiotika ključna je u sprječavanju razvoja otpornosti na lijekove. Postoje određeni parametri, poput minimalnih inhibitornih koncentracija, koji se koriste za određivanje osjetljivosti mikroorganizama na lijekove. Nedostatak tih parametara u veterinarskoj medicini predstavlja izazov, pa je važno provoditi istraživanja kako bismo ih bolje razumjeli. Odbor za testiranje osjetljivosti veterinarskih lijekova naglasio je nedostatak tih parametara, te su predložene smjernice za njihovo određivanje. Kontinuirana istraživanja farmakokinetike u veterinarskoj medicini su važna jer omogućuju precizno određivanje doza antibiotika, što pomaže u borbi protiv otpornosti na lijekove. Cilj istraživanja je utvrditi farmakokinetičke parametre određenih antibiotika u životinjama gdje takvi podaci nedostaju. Bez tih istraživanja teško je odrediti točne doze, što može dovesti do nedovoljnog ili pretjeranog davanja lijekova. To može rezultirati razvojem otpornosti na lijekove, što predstavlja ozbiljan javni zdravstveni problem. Laboratorij Sveučilišta u Pisi provodi istraživanja na životinjama koje se koriste u prehrambene svrhe. Ti podaci su ključni za pravilno propisivanje vremena karenca, utvrđivanje rezidua i odgovorno doziranje antibiotika u okviru koncepta ""Jedno zdravlje"". Asistent će sudjelovanjem u istraživanju razviti vještine za samostalno dizajniranje i provođenje sličnih eksperimenata, analizu podataka i tumačenje rezultata. Dobiveno razumijevanje kompleksnosti doziranja lijekova u različitim životinjskim vrstama je nužno za razvoj dobre veterinarske prakse u Republici Hrvatskoj i razumijevanju povezanosti zdravlja ljudi, životinja i okoliša.Organizacija-domaćin: University of Pisa, Department of Veterinary Sciences]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16330</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Luka Poslon]]></title_hr><title_en><![CDATA[]]></title_en><user_id>865136</user_id><user_firstLast_name>Luka Poslon</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-7970</code><acronim><![CDATA[]]></acronim><duration>21.03.2024 - 21.06.2024</duration><status>U tijeku</status><financ_value>7.905,00 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filozofija, </scie_field_hr><scie_field_en>Philosophy, </scie_field_en><institution_hr><![CDATA[Hrvatsko katoličko sveučilište, Zagreb]]></institution_hr><institution_en><![CDATA[Catholic University of Croatia]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Asistent će u sklopu znanstveno-istraživačkog usavršavanja istraživati etičko-epistemološke izazove objašnjivosti u modelima umjetne inteligencije koji proizlaze iz black box efekta, gdje pružatelji usluga ne mogu objasniti odluke i način rada modela umjetne inteligencije. Nedostatak transparentnosti i objašnjivosti Al modela mogu dovesti do potencijalno diskriminirajućih ili štetnih rezultata, kao što su netočne medicinske dijagnoze. Netočne medicinske dijagnoze mogu negativno utjecati na zdravlje pacijenata kao i na povjerenje u korištenje algoritamskih rješenja u zdravstvenoj skrbi. Kako bi se riješio problem nedostatka transparentnosti i objašnjivosti, asistent će uspostaviti jasne smjernice i propise za poticanje transparentnosti i objašnjivosti u korištenju digitalnih tehnologija kako bi se razvilo povjerenje u korištenje Al modela. Objašnjiva umjetna inteligencija (xAl) može učiniti algoritamska predviđanja intuitivnijima i dodatno povećati povjerenje kroz pristup usmjeren na čovjeka.Organizacija-domaćin: High-Performance Computing Center Stuttgart]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16331</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Margareta Sigmund]]></title_hr><title_en><![CDATA[]]></title_en><user_id>866600</user_id><user_firstLast_name>Margareta Sigmund</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-1595</code><acronim><![CDATA[]]></acronim><duration>05.04.2024 - 04.07.2024</duration><status>U tijeku</status><financ_value>7.735,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Lake atomske jezgre pokazuju širok spektar struktura, od savršeno oblih, kuglastih oblika do egzotičnih trokutastih i lančastih struktura. Budući da lake atomske jezgre imaju mali broj nukleona, moguće je na jednostavniji način proučavati međudjelovanje jake sile između sastavnih dijelova jezgre, protona i neutrona, jednim imenom nukleona. Već u vrlo laganim sustavima poput jezgre atoma helija uočavamo kako se nukleoni rado vežu u sustav dva protona i dva neutrona što im daje izrazitu stabilnost u odnosu na ostale strukture. Takav sustav nazivamo klasterom ili alfa česticom. |straživanja su pokazala da klasteriranje igra važnu ulogu u formiranju nama danas poznatih kemijskih elemenata. Da nema klasteriranja u jezgri ugljika 12C, nama poznati svijet bio bi značajno drugačiji, te ne bi bilo elemenata od ugljika do oganesona. Klasteriranje je najizraženije u jezgrama s jednakim brojem protona i neutrona, a u jezgrama koje imaju veći broj neutrona u odnosu na broj protona, uočen je fenomen koji nazivamo nuklearnim molekulama. Naime, višak neutrona popunjava orbitale slične orbitalama u atomskim molekulama. Tako je teorijskim računima pokazano da bi se na višim energijama pobuđenja nukleoni u jezgri ugljika C mogli formirati u lanac tri alfa-čestice oko kojih se gibaju četiri preostala neutrona. Ti preostali neutroni povećavaju stabilnost takve egzotične strukture i zbog toga čine istraživanje neutronski bogatih lakih jezgara zanimljivim. Do sada u eksperimentalnim istraživanjima postoje tek naznake takve građe s nedovoljnom statistikom. Tema doktorskog rada asistentice je eksperimentalna potraga za klasterskim strukturama u jezgri 16C, te ostalim izotopima ugljika s manjim brojem neutrona 13,14,15C. U doktorskom radu asistentica će obraditi rezultate eksperimenta na akceleratorskom postrojenju za radioaktivne snopove na TRIUMF-u u Vancouveru, Kanada.Tijekom studijskog boravka na Sveučilištu u Napulju asistentica će napraviti preliminarnu analizu trenutno dostupnih podataka, napraviti detaljne računalne simulacije te istraživati moguća unaprjeđenja i poboljšanja predloženog eksperimentalnog postava. Također će se upoznati s algoritmima i računalnim kodovima strojnog učenja te će raditi na njihovoj primjeni u eksperimentalnoj nuklearnoj fizici, čime se dosada nitko nije bavio unutar nuklearne fizike u Hrvatskoj.Organizacija-domaćin: Universita degli Studi di Napoli &#39;Federico II&#39;]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16332</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Mladen Miletić]]></title_hr><title_en><![CDATA[]]></title_en><user_id>29067</user_id><user_firstLast_name>Mladen Miletić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-4074</code><acronim><![CDATA[]]></acronim><duration>16.04.2024 - 21.05.2024</duration><status>U tijeku</status><financ_value>3.060,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Tehnologija prometa i transport, </scie_field_hr><scie_field_en>Transport technology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet prometnih znanosti]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Transport and Traffic Sciences]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Tijekom znanstveno-istraživačkog usavršavanja, asistent Mladen Miletić posvetit će se razvoju naprednih sustava upravljanja prometom temeljenih na višeagentnom potpornom učenju. Glavni cilj istraživanja je optimizacija protočnosti prometa na raskrižjima, smanjenje zagušenja te poboljšanje cjelokupnog prometnog sustava u gradskim sredinama. U prvom planu cilj je implementacija razvijenog sustava upravljanja prometom na odabranim raskrižjima u simulacijskom okruženju, što će omogućiti ispitivanje učinkovitosti razvijenog sustava upravljanja. Osim toga, asistent će aktivno surađivati s istraživačima na instituciji domaćinu kako bi se kroz diskusiju ostvario kvalitetan prijenos znanja iz domene višeagentnih sustava. Nadalje, planira se proširenje razvijenog sustava na veći broj raskrižja, što će doprinijeti globalnoj optimizaciji prometnih sustava. Osim toga, asistent će izraditi smjernice za daljnji razvoj sustava za upravljanje raskrižjima, čime će biti postavljeni temelji za dugoročne inovacije u području upravljanja prometom. Sve ove aktivnosti imaju za cilj stvaranje održivih i učinkovitih gradskih prometnih sustava, čime se direktno odgovara na izazove vezane uz gradsku mobilnost i promet. Ostvareni inicijalni znanstveni rezultati će se prezentirati na relevantnim znanstvenim konferencijama, dok će se završni rezultati kao i razvijeni upravljački sustav detaljno opisati u radu koji će se napisati za objavu u znanstvenom časopisu. Jačanjem suradnje s institucijom domaćinom omogućuje se bolja podloga za nove projektne prijave i daljnji nastavak znanstveno-istraživačkog rada.Organizacija-domaćin: Trinity College Dublin, University of Dublin]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16333</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Patrick Seleš]]></title_hr><title_en><![CDATA[]]></title_en><user_id>866637</user_id><user_firstLast_name>Patrick Seleš</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-4212</code><acronim><![CDATA[]]></acronim><duration>22.04.2024 - 21.07.2024</duration><status>U tijeku</status><financ_value>7.735,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut za fiziku]]></institution_hr><institution_en><![CDATA[Institute of Physics in Zagreb]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Istraživanje materijala koji imaju debljinu jednog ili svega nekoliko atoma — tzv. 2D materijala — intenzivno se provodi u brojnim istraživačkim grupama diljem svijeta. Između ostalih, tim materijalima pripadaju heksagonalni borov nitrid (nBN) i borofen, gdje se hBN ističe svojim izolatorskim svojstvima i kemijskom inertnošću a borofen visokom električnom i termalnom vodljivošću. Ovim projektom će se istražiti novi načini sinteze tih materijala na bakrenim podlogama s ciljem povećanja njihove strukturne kvalitete i dobivanja materijala s jasno definiranim intrinzičnim svojstvima. Dodatno, ispitati će se mogućnosti dobivanja vertikalnih hBN/borofen heterostruktura kao robusnih nanoskopskih sistema s novim funkcionalnostima. Odabir bakrenih podloga za sintezu je zanimljiv s aspekta potencijalnih budućih primjena ovih 2D materijala odnosno kompatibilnosti s današnjim industrijskim standardima. Sveukupno, provedbom projekta će se dobiti novi uvid u procese sinteze 2D materijala i njihove integracije u kompleksnije heterostrukture.Organizacija-domaćin: University Duisburg-Essen]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16335</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Lidija Posavec]]></title_hr><title_en><![CDATA[]]></title_en><user_id>858398</user_id><user_firstLast_name>Lidija Posavec</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-6116</code><acronim><![CDATA[]]></acronim><duration>15.05.2024 - 17.06.2024</duration><status>U tijeku</status><financ_value>2.890,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Kemijska sinteza se tradicionalno provodi u otopini, što na laboratorijskoj i industrijskoj skali znači tone toksičnih otpadnih otapala godišnje. Iz tog razloga, otkrivanje alternativnih načina sinteze koji su energetski učinkovitiji i proizvode minimalan udio otpada su od izuzetne važnosti. Jedan od takvih načina predstavlja mehanokemija. Mehanokemijska sinteza se odnosi na izvođenje reakcija u čvrstom stanju pomoću uvođenja mehaničke energije, bez upotrebe otapala ili korištenjem katalitičkih količina otapala. Mehanokemijska sinteza uključuje načela zelene kemije se odnose na provođenje kemijskih procesa i reakcija uz minimalni utjecaj na okoliš.Cilj ovog znanstveno-istraživačkog usavršavanja jest mehanokemijska sinteza novih metaloorganskih materijala temeljenih na halogenskim vezama. Halogenska veza jest međumolekulska interakcija slična vodikovoj vezi, međutim donor halogenske veze je elektrofilni dio atoma halogena dok su akceptori nukleofilni atomi kao što su O, N, S, Se, Cl i slično. Glavna ideja usavršavanja je sinteza višekomponentnih kristala koji sadrže perhalogenirane organske molekule kao donore te metalne koordinacijske spojeve kao akceptore halogenske veze. U planu je korištenje inovativnih tehnika za mehanokemijsku sintezu: tehnike brzog miješanja (eng. speed mixing), te rezonantnog akustičnog miješanja (eng. resonance acoustic mixing) kako bi se selektivno sintetizirali višekomponentnih metaloorganski sustavi koji su prethodno sintetizirani iz otopine. Tehnika rezonantnog akustičnog miješanja se temelji na mehanokemijskoj aktivaciji reaktanata specifičnom frekvencijom uređaja, bez korištenja bilo kakvog medija za mljevenje ili gnječenje. Tehnika brzog miješanja se zasniva na dualnoj asimetričnoj centrifugalnoj (DAC) tehnologiji miješanja koja omogućava miješanje reaktanata bez medija za mljevenje. Ove tehnike imaju prednost nad konvencionalnim mlinovima za mehanokemijsku sintezu jer ne koriste dodatne medije za mljevenje čime se sprječava kontaminacija produkata zbog abrazije materijala što ih čini primjenjivim na industrijskoj skali Selektivna sinteza materijala će se postići optimizacijom reakcijskih uvjeta pri sintezi (vremena reakcije, tekućih aditiva, promjenom intenziteta miješanja, reakcijskih posudica i slično). Istraživanje provedeno u sklopu ovog usavršavanja pružit će dodatan uvid u pripravu višekomponentnih kristala, što je izuzetno zanimljivo područje istraživanja pošto je povezivanje više od dvije komponente u kristalu izuzetno zahtjevno.Organizacija-domaćin: University of Birmingham]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16336</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Rafaela Radičić]]></title_hr><title_en><![CDATA[]]></title_en><user_id>865330</user_id><user_firstLast_name>Rafaela Radičić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-9512</code><acronim><![CDATA[]]></acronim><duration>02.05.2024 - 31.07.2024</duration><status>U tijeku</status><financ_value>7.735,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut za fiziku]]></institution_hr><institution_en><![CDATA[Institute of Physics in Zagreb]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Površina polimera može biti modificirana putem hladnih plazmi kako bi im se poboljšala površinska svojstva poput adhezija, vlažnost i biokompatibilnost za razne primjene. U sklopu usavršavanja asistentica će tretirati plazmom prirodne i održive polimerne derivate koji se koriste u tekstilnoj i prehrambenoj industriji te će u njih ugraditi nanočestice dodatno poboljšavajući svojstva. Proučavat će i ulogu površinske obrade plazmom na vlaženje i adheziju kompozitnih polimera te utjecaj atmosferskog plazmenog mlaza na povećanje površinske energije i reaktivnosti polimera. Polimeri koji će se koristiti bit će polietilen i polietilentereftalat dok će se tretman vršiti s pomoću atmosferskog plazmenog mlaza i niskotlačnih plazmi raznih plinova. Nanočestice od interesa su ZnO, Ag i TiO2, a sintetizirat će se s pomoću laserske ablacije pripadnih meta u tekućinama na Institutu za fiziku. Polimeri s nanočesticama će se dodatno analizirati na Institutu za fiziku na testove mjerenja stopa curenja nanočestica iz njih. Također, koristit će se infracrvena spektroskopija s Fourierovom transformacijom za određivanje kemijskih veza i goniometar za određivanje kontaktnog kuta. Također, nanočestice će se karakterizirati putem UV-Vis spektrofotometra, spektrofluorimetra te dinamičkog raspršenja svjetlosti. Na Institutu Jožef Stefan bit će nam dostupne, uz druge izvore plazme poput niskotlačnih plazmi, razne karakterizacijske tehnike poput rendgenske fotoelektronske spektroskopije, transmisijske elektronske mikroskopije, pretražne elektronske mikroskopije i masenog spektrometra sekundarnih iona.Organizacija-domaćin: Institut Jožef Stefan]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16340</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Katarina Tutić]]></title_hr><title_en><![CDATA[]]></title_en><user_id>866593</user_id><user_firstLast_name>Katarina Tutić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-7040</code><acronim><![CDATA[]]></acronim><duration>15.05.2024 - 15.10.2024</duration><status>U tijeku</status><financ_value>13.090,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Građevinarstvo, </scie_field_hr><scie_field_en>Civil engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Građevinski fakultet u Rijeci]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Civil Engineering]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[U okviru znanstveno-istraživačkog usavršavanja, naglasak je na provođenju istraživanja usmjerenog na razvoj računalnog koda namijenjenog numeričkoj simulaciji problema ljuljanja krutog bloka na elastičnoj gredi. Ključni fokus istraživanja leži u primjeni pristupa ne-glatke kontaktne dinamike. Ovaj pristup, radi matematičkih specifičnosti problema, zahtijeva suradnju s uglednim stručnjakom iz područja matematičkog modeliranja i numeričkih metoda, profesorom Martinom Arnoldom. Hrvatska istraživačka skupina također posjeduje značajno iskustvo u području računske mehanike, orijentirano uglavnom na primjenu na stvarne inženjerske probleme. Nadalje, hrvatski tim se posebno ističe i u domeni eksperimentalne mehanike.Rezultati ovog usavršavanja bit će od važnosti u identifikaciji uvjeta koji dovode do prevrtanja krutog bloka, što će pridonijeti značajnim inovacijama u dizajnu konstrukcija. Ciljevi istraživanja nalaze široku primjenu u stvarnim problemima, a omogućuju poboljšanje sigurnosti i učinkovitosti u stvarnim inženjerskim situacijama, naročito u područjima potresne analize konstrukcija (Slika 1.) i analize konstrukcija pod opterećenjem strojeva. Očekuje se da će ovo istraživanje ne samo pridonijeti teorijskom razumijevanju problema ljuljanja krutih blokova na elastičnim gredama, već će također omogućiti konkretne korake prema inovativnim rješenjima u inženjerskoj praksi. Razvoj računalnog koda koji će proizaći iz ovog usavršavanja bit će ključan temelj za doktorsku disertaciju prijaviteljice. Sveukupno, ovo istraživanje predstavlja značajan korak prema unapređenju inženjerskih pristupa s ciljem optimizacije konstrukcija i povećanja njihove pouzdanosti u dinamičkim uvjetima.Organizacija-domaćin: Martin Luther University Halle-Wittenberg, Institute of Mathematics]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16341</id><title_hr><![CDATA[Odlazna mobilnost asistenata - David Visentin]]></title_hr><title_en><![CDATA[]]></title_en><user_id>867625</user_id><user_firstLast_name>David Visentin</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-6712</code><acronim><![CDATA[]]></acronim><duration>06.08.2024 - 06.11.2024</duration><status>U tijeku</status><financ_value>7.905,00 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Biotehnologija, </scie_field_hr><scie_field_en>Biotechnology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Fakultet biotehnologije i razvoja lijekova]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Biotechnology and Drug Development]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Doktorsko istraživanje Davida Visentina usmjereno je na proučavanje patogenih bakterija povezanih s parodontitisom i njihov potencijalni utjecaj na integritet krvno-moždane barijere te funkciju živčanog sustava. Ovo istraživanje obuhvaća analizu bakterija Porphyromonas gingivalis, Tannerella forsythia, Treponema denticola i Fusobacterium nucleatum, koje zajedno tvore biofilm.Smatra se da je P. gingivalis ključni patogen koji s faktorima virulencije uzrokuju upalu i oštećenje tkiva. T. forsythia koristi proteaze poput PrtH za doprinos parodontitisu. T. denticola regulira imunološki odgovor domaćina. F. nucleatum je oralni komensal, povezan s formiranjem plaka i peridontitisom. Infekcija peridontalnim patogenima može dovesti do kronične sistemske upale, s povećanim razinama citokina koje posljedično mogu dovesti do neuroinflamacije. To je dodatno potvrđeno sa činjenicom da uspješni tretmani peridontalne bolesti mogu obrnuti razine sistemskih upalnih markera.Dokazana je povezanost između povišene razine proupalnih citokina s neuralnim poremećajima kao depresija, dok degradacija krvno-moždane barijere dodatno potiče progresiju bolesti (9). Neuroinflamacija igra ulogu u bolestima poput multiple skleroze, Alzheimerove bolesti i Parkinsonove bolesti.U sklopu posjeta domaćinu bi doktorand usavršio svoje vještine u području bioinformatiku vezane za statističku obradu i analizu mikrobioma. To znanje i zajednički radovi bi doprinijeli razumijevanju odnosa patogena i neuroloških poremećaja.Organizacija-domaćin: University of Copenhagen, Danska]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16347</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Petra Grebenac]]></title_hr><title_en><![CDATA[]]></title_en><user_id>865119</user_id><user_firstLast_name>Petra Grebenac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-3721</code><acronim><![CDATA[]]></acronim><duration>23.08.2024 - 25.09.2024</duration><status>U tijeku</status><financ_value>2.890,00 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filologija, </scie_field_hr><scie_field_en>Philology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[U disertaciji asistentica istražuje pjesništvo Marije Stepanove, jedne od najznačajnijih suvremenih ruskih pjesnikinja. Njezino stvaralaštvo obilježeno je transformacijama na svim razinama pjesničkog teksta: tematskoj, žanrovskoj, formalnoj i jezičnoj. Disertacija razmatra osobitosti svih navedenih razina teksta na primjerima lirskog i lirsko-epskog pjesništva Marije Stepanove, s posebnim naglaskom na istraživanje tekstualnog subjekta.Budući da se poezija Marije Stepanove, kao i poezija drugih suvremenih ruskih pjesnika, odlikuje žanrovskom raznolikošću, ali i transformacijama samih granica i funkcija književnih žanrova i rodova, pri obrazlaganju metodologije istraživanja problematizira se upotreba uvriježenih pojmova uvjetovanih klasičnom rodovskom podjelom, kao što su lirika, lirski subjekt i lirsko ja, koji su se pokazali nedovoljno obuhvatnima za analizu odabranog korpusa. Umjesto navedenih generički obilježenih pojmova u istraživanju se za označavanje krovne kazivačke instancije koriste pojmovi tekstualni subjekt ili pjesnički subjekt. Metodološki alati razrađuju se s ciljem njihove primjene na analizu pjesničkih zbirki Marije Stepanove objavljenih od 2001. do 2017. godine. Zbirke se analiziraju prema kronološkom i žanrovskom kriteriju, što omogućuje rekonstrukciju razvoja žanrovsko-subjektnih transformacija u pjesničkim tekstovima Stepanove. Zaključuje se da su prve tri objavljene zbirke lirskih pjesama (O blizancima, 2001.; Tu-svijet, 2001.; Sreća, 2003.) usmjerene na istraživanje mogućnosti eksperimentiranja s artikulacijom pjesničkog subjektiviteta; balade i poeme 2000-ih (Pjesme sjevernih južnjaka, 2001.; Drugi, 2003.; Proza Ivana Sidorova, 2008; Druga proza, 2010.) imaju jasnu podjelu na pripovjedača i likove, između kojih se povremeno brišu ili zamućuju granice; zbirke lirske poezije iz druge polovice 2000-ih (Fiziologija i mala povijest, 2005.; Lirika, glas, 2010.) odlikuju se izrazito autobiografski obilježenim pjesničkim subjektom; Žanrovski hibridne pjesničke zbirke iz 2010-ih (Kireevskij, 2012; Spolia, 2015.) mogu se čitati i kao pjesnički ciklusi, ali i kao labavo strukturirane poeme koje nemaju jedan središnji narativ niti jasnu raspodjelu likova i u potpunosti su izgrađene na principu kolažiranja citatnih fragmenata. Osim što nastoji apstrahirati različite strategije artikulacije pjesničkog subjektiviteta i rekonstruirati njihovu evoluciju u opusu Marije Stepanove, istraživanje opisuje i funkcije tih strategija: problematiziranje singularnosti i stabilnosti identiteta pjesničkog subjekta, dočaravanje nestabilne, difuzne, rascijepljene svijesti suvremenog pojedinca, ostvarivanje pogranične i fantastične atmosfere svijeta pjesme.Očekuje se da će disertacija ponuditi promišljen i razrađen uvid u opus Marije Stepanove, koji se zbog svoje svestranosti i inovativnosti smatra jednim od glavnih orijentira različitim strujanjima u suvremenoj ruskoj poeziji. Osim što će kontekstualizacija i analiza reprezentativnog korpusa dati uvid u prevladavajuće tendencije razvoja cjelokupne suvremene ruske poezije, očekuje se da će istraživanje ponuditi relevantan teorijski i metodološki okvir za istraživanje poezije Marije Stepanove, ali i suvremene poezije općenito.Organizacija-domaćin: Trier University, Njemačka]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16361</id><title_hr><![CDATA[Razotkrivanje enigme fitoplazme &#39;Candidatus Phytoplasma solani&#39;: Interakcije njenih efektorskih proteina s domaćinskim biljkama ]]></title_hr><title_en><![CDATA[Unravelling the enigma of ‘Candidatus Phytoplasma solani’: Interactions of its effector proteins with host plants]]></title_en><user_id>12617</user_id><user_firstLast_name>Martina Šeruga Musić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>WEAVE</proposal_type><proposal_call>2024</proposal_call><code>WEAVE-2024-3910</code><acronim><![CDATA[CAPSEFFECT]]></acronim><duration>15.02.2025 - 14.02.2028</duration><status>U tijeku</status><financ_value>169.500,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>11295, 26493, 868747, 861744, </team_members_id><team_members_names><![CDATA[Dijana Škorić, Marina Drčelić, Dino Davosir, Iva Marković, ]]></team_members_names><keywords_hr><![CDATA[phytoplasmas, transcriptomics, plant pathology, protein interaction, plant immunity, grapevine, effector, arabidopsis]]></keywords_hr><keywords_en><![CDATA[fitoplazme, transkriptomika, biljna patologija, interakcije proteina, vinova loza, biljna imunost, efektor, arabidopsis]]></keywords_en><summary_hr><![CDATA[Unutarstanične bakterije bez stanične stijenke, fitoplazme (rod &#39;Candidatus Phytoplasma&#39;) obuhvaćaju raznoliku skupinu patogena koji zaražavaju brojne biljne vrste i uzrokuju značajne štete u poljoprivredi diljem svijeta. Dok njihova ekonomska važnost raste, studije povezane s mehanizmima patogenosti još uvijek su otežane zbog nemogućnosti uzgoja in vitro. U Europskoj uniji, vinogradarska industrija ugrožena je bolestima žutica vinove loze, posebno onima povezanima s &#39;Ca. Phytoplasma solani&#39;, koja uzrokuje značajne gubitke bez trenutno dostupnih odgovarajućih mjera kontrole. S obzirom na hitnu potrebu za učinkovitom kontrolom fitoplazmi, ključno je dublje razumijevanje njihovih mehanizama patogenosti. Kako bi postigle svoju patogenost i uspješno manipulirale svojim domaćinima, biljkama i kukcima, fitoplazme izlučuju efektore, male multifunkcionale proteine koji su u interakciji sa stanicom domaćina. U našim prethodnim projektima sekvencirali smo soj SA-1 fitoplazme &#39;Ca. P. solani&#39; gdje je pomoću bioinformatičkih alata identificirano 38 potencijalnih efektora i započeto s funkcionalnim studijama odabranih potencijalnih efektora. U ovom projektu sa slovenskim kolegama kao vodećim partnerima, unutar 5 ciljeva, težit ćemo daljnjem istraživanju efektora fitoplazme &#39;Ca. P. solani&#39; te pokušati razjasniti mehanizme interakcije između efektora i višestrukih meta domaćina, posebno u povezanih s imunitetom biljaka, provesti biokemijske karakterizacije i karakterizacije transkriptoma transformiranih biljaka, kao i istražiti raznolikosti repertoara i ekspresije efektora. Koristit će se najsuvremenija metodologija, uključujući transkriptomiku, proteomiku, metabolomiku i genomiku na modelnim biljkama kao što su arabidopsis i madagaskarski zimzelen, te na vinovoj lozi. Rezultati projekta također će pružiti vrijedan uvid u imunološki odgovor biljaka na zarazu fitoplazmom, što će u konačnici dovesti do razvoja inovativnih strategija upravljanja i kontrole ovih bolesti u budućnosti]]></summary_hr><summary_en><![CDATA[Endocellular wall-less bacteria known as phytoplasmas (genus ‘Candidatus Phytoplasma’) encompass a diverse group of pathogens affecting numerous plant species and causing significant damage in agriculture worldwide. While economic importance is increasing, studies related to their pathogenicity mechanisms are still hindered due to the inability of cultivation in vitro. In the European Union, the grapevine industry is severely threatened by Grapevine Yellows diseases, in particular by those associated to &#39;Ca. Phytoplasma solani&#39;, having significant economic losses without adequate control measures currently available. Given the urgent need for effective control of phytoplasmas, a deeper understanding of their mechanisms is crucial. In order to achieve their pathogenicity and successfully manipulate their plant and insect hosts, phytoplasmas secrete effectors, small multifaceted proteins interacting with host cell and having multiple targets. In our previous projects, we sequenced a &#39;Ca. P. solani&#39; strain SA-1 where 38 potential effectors were identified by using bioinformatics tools and started with functional studies of selected potential effectors. In this project with Slovenian colleagues as leading partners, within 5 objectives, we will aim to further study &#39;Ca. P. solani&#39; effectors and elucidate mechanisms of interaction between effectors and multiple host targets, particularly related to plant immunity, to perform biochemical and transcriptomic characterization of effector transformed plants, as well as to decipher diversity of repertoire and expression of effectors. State-of-the-art methodology will be used, including transcriptomics, proteomics, metabolomics and genomics approach in model plants such as Arabidopsis and periwinkle, as well as in grapevine. The results of the project will also provide valuable insights into the plant immune responses to phytoplasma, leading to development of innovative disease management and control strategies in the future.]]></summary_en></project><project>
<id>16382</id><title_hr><![CDATA[Električni romobili u urbanim okruženjima: Studija sigurnosti, infrastrukture i dinamike mobilnosti]]></title_hr><title_en><![CDATA[Electric scooters in urban environments: A study of safety, infrastructure, and mobility dynamics]]></title_en><user_id>1303</user_id><user_firstLast_name>Dario Babić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>WEAVE</proposal_type><proposal_call>2024</proposal_call><code>WEAVE-2024-3188</code><acronim><![CDATA[eSCURB]]></acronim><duration>01.02.2025 - 31.01.2028</duration><status>U tijeku</status><financ_value>161.710,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Tehnologija prometa i transport, Arhitektura i urbanizam, Građevinarstvo, Interdisciplinarne tehničke znanosti, </scie_field_hr><scie_field_en>Transport technology, Architecture and Urban Environment, Civil engineering, Interdisciplinary technological sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet prometnih znanosti]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Transport and Traffic Sciences]]></institution_en><team_members_id>866706, 21413, 873043, 873230, </team_members_id><team_members_names><![CDATA[Mario Fiolić, Darko Babić, Shirin Rizehbandi, Marija Ferko, ]]></team_members_names><keywords_hr><![CDATA[električni romobili, urbani sustavi, održiva mobilnost, mikromobilnost, prometna sigurnost, ponašanje u mobilnosti]]></keywords_hr><keywords_en><![CDATA[electric scooters, urban systems, sustainable mobility, micromobility, traffic safety, mobility behaviour]]></keywords_en><summary_hr><![CDATA[Electricni romobili su važna i sve popularnija tehnologija u urbanim područjima kao sredstvo privatne pa čak i dijeljene mobilnosti. U tom smislu, uvođenje e-romobila u urbano kretanje predstavlja jedno rješenje za balansiranje održive mobilnosti i potreba mobilnih korisnika. Međutim, urbanu mobilnost donekle ograničava velik broj i razvijene gradove s cestovnom infrastrukturom koja je razvijana za potrebe prometa i transporta proteklih desetljeća i stoljeća. Budući da trenutno ne postoji urbana infrastruktura namijenjena isključivo za e-romobile i s brzorastućom uporabom takvog načina prijevoza, postoje zabrinutosti vezane uz sigurnost i dugoročnu funkcionalnost urbanih prometnih sustava, posebice kada postoji mogućnost višestrukih sukoba e-romobila s drugim sudionicima u urbanom prometnom sustavu. Međutim, ako se njihova uporaba želi poticati i pretvoriti u široku uporabu, potrebno je što prije provesti temeljitu analizu svih aspekata njihove uporabe kako bi se prekinuo ciklus neuređene ili nedovoljno regulirane uporabe i kako bi se mogli integrirati u urbanu mobilnost. Glavni cilj je razabrati na koji način električni romobili i njihovi korisnici trenutno sudjeluju u mobilnosti u urbanom kontekstu, kako to utječe na njihovu sigurnost i opću sigurnost svih sudionika u mobilnosti te kako prometna sigurnost utječe na pojavu sve veće uporabe električnih romobila u urbanim kontekstima. Projekt je interdisciplinaran jer će se infrastrukturna, ponašajna, psihološka, sigurnosna i logistička pitanja analizirati i rješavati s nizom kvantitativnih i kvalitativnih metoda. Konačni cilj je razviti duboko razumijevanje na koji način su električni romobili uključeni u tradicionalnu mješavinu mobilnosti i razviti smjernice o tome kako ih sigurno i održivo uključiti kako bi se maksimalno iskoristile njihove potencijalne prednosti za osobnu mobilnost u urbanom kontekstu.]]></summary_hr><summary_en><![CDATA[Electric scooters are an important and emerging technology in urban areas that are increasingly popular as a means of private and even shared mobility. In that regard, introducing e-scooters into urban mobility presents one solution for balancing sustainable mobility and the needs of mobile users. However, urban mobility is limited to some extent in large and developed cities with road infrastructure that has been developed for traffic and transportation needs over the last decades and centuries. With no current urban infrastructure designed exclusively for e­scooters and with the fast-growing use of that type of transportation mode, there are concerns related to the safety and long-term functionality of urban transport systems, especially when there is a possibility of multiple conflicts of e­scooters with other participants in the urban mobility system, However, if they are to be encouraged and transformed into widespread use, an In-depth analysis of all aspects of their use needs to be performed as soon as possible so that the cycle of unregulated or under-regulated use is broken and they can be integrated into urban mobility, The main aim is to discern how electric scooters and their users currently take part in the mobility sphere in an urban context, how this influences their safety and the general safety of all mobility participants, and how traffic safety is impacted by the emergence of increasing electric scooter use in urban contexts. The project is interdisciplinary since infrastructural, behavioral, psychological, safety, and logistical issues will be analyzed and addressed with a multitude of quantitative and qualitative methods. The final goal is to develop an in-depth understanding of how electric scooters are included in the traditional mobility mix and to develop guidelines on how to incorporate them in a safe, sustainable way to maximally use their potential benefits for personal mobility in an urban context.]]></summary_en></project><project>
<id>16387</id><title_hr><![CDATA[Izloženost ljudi zračenju uređajima novih tehnologija bežičnih komunikacija primjenom naprednih modela elektromagnetsko-topllinske dozimetrije]]></title_hr><title_en><![CDATA[Human Exposure to Radiation from new Wireless Communication Technologies using Advanced Electromagnetic-Thermal Dosimetry Models]]></title_en><user_id>11109</user_id><user_firstLast_name>Dragan Poljak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>WEAVE</proposal_type><proposal_call>2024</proposal_call><code>WEAVE-2024-7779</code><acronim><![CDATA[HERWICT]]></acronim><duration>01.02.2025 - 31.01.2028</duration><status>U tijeku</status><financ_value>140.716,68 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Fakultet elektrotehnike, strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Electrical Engineering, Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>28936, 24066, 7189, 866283, 871153, 871150, 871845, </team_members_id><team_members_names><![CDATA[Zoran Blažević, Vicko Dorić, Maja Škiljo, Anna Šušnjara, Hrvoje Dodig, Klementina Vidjak, Marin Galić, ]]></team_members_names><keywords_hr><![CDATA[Prijenos topline u biološkim tkivima, multifazni tok, fizikalno informirane neuronske mreže, visokofrekvencijsko zračenje, 5G, 6G, dozimetrija]]></keywords_hr><keywords_en><![CDATA[Bioheat transfer, multiphase flow, physics informed neural networks, high frequency radiation, 5G, 6G, dosimetry]]></keywords_en><summary_hr><![CDATA[Potreba za višim brzinama prijenosa i povećanja kapaciteta dovela je do primjene mm valova u novim bežičnim sustavima, poput 5G mobilnih sustava koji zahtjevaju značajno veći broj antena. Zabrinutost javnosti uslijed izloženosti 5G sustavima postaje goruće pitanje pa su uz postojeće studije potrebna dodatna istraživanja. U nedavno objavljenim IEEE i ICNIRP smjernicama jedinstvena prijelazna frekvencija je 6GHz iznad koje se koristi gustoća apsorbirane snage (APD) usrednjena po specificiranoj površini u bliskom polju, umjesto specifične gustoće apsorbirane snage (SAR) usrednjene po volumenu tkiva (uslijed zagrijavanja u unutrašnjosti tkiva).  Uskoro se očekuje implementacija ovih internacionalnih smjernica u nacionalnim regulativama, poput hrvatskih ili slovenskih. Predloženi projekt bavi se determinističko-stohastičkom elektromagnetsko (EM) – toplinskom dozimetrijom za izloženost ljudi 5G sustavima. U projektu se predlaže kombinacija više metoda: konformne metode za dozimetriju polja, precizan model krvotoka i spregnuti model protoka i prijenosa topline u ljudskom tkivu uslijed EM polja induciranog u tkivu koje se računa metodama za proračun veličina unutarnje dozimetrije. Glavni cilj projekta je razviti realistične modele te odgovarajuće numeričke metode visoke preciznosti kao što su metode rubnih i konačnih elemenata/volumena i hibridne tehnike. Dobiveni numerički rezultati za APD i posljedično povećanje temperature usporedit će se s eksperimentalnim rezultatima dobivenim uporabom fantoma ljudske glave. Budući da deterministički modeli nisu dovoljni za predstavljanje parametara koji karakteriziraju realne scenarije, oni će se kombinirati sa stohastičkim pristupom, koji uključuje neintruzivnu stohastičku metodu kolokacije. Naposljetku, usvojit će se moderne tehnike aproksimacije, kao što su fizikalno informirane neuronske mreže za razvoj brzih aproksimativnih modela prikladnih za korištenje bez upotrebe superračunala.]]></summary_hr><summary_en><![CDATA[A necessity for higher transmission rate and network capacity has led to the use of the mm-wave spectrum for 5G mobile systems which require appreciably higher number of antennas. Public concern on potential adverse health effects due to exposure to 5G systems have become a rather hot issue, hence additional research is required. Recently released guidelines IEEE and ICNIRP have merged towards 6GHz as a unique transition frequency above which absorbed power density (APD) averaged over a specific area is suggested in the near field, instead of specific absorption rate (SAR) being averaged over tissue volume. These international guidelines are soon expected to be implemented in national regulations, such as Croatian and Slovenian. The proposed project deals with deterministic-stochastic electromagnetic-thermal dosimetry procedures for exposure of humans to 5G systems. We propose a combination of techniques: a conformal method for incident field dosimetry, an accurate model for blood flow and coupled flow – heat transfer model of the human tissue subjected to internal electromagnetic dosimetry. The principal goal of the project is to develop the realistic models accompanied with highly accurate numerical methods such as Boundary Element Method, Finite Element/Volume Method and hybrid techniques. The obtained numerical results for APD and related temperature increase will be compared to the experimental results obtained using a head phantom. As deterministic computational models are not enough to represent relevant parameters which characterize realistic scenarios they will be combined with stochastic approach, featuring non-intrusive stochastic collocation method. Finally, as the developed techniques are expected to require substantial computational resources, we will adopt modern approximation techniques, such as physics informed neural networks to develop fast approximate models suitable for use without supercomputers.]]></summary_en></project><project>
<id>16395</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Antonia Vukmirović]]></title_hr><title_en><![CDATA[]]></title_en><user_id>865175</user_id><user_firstLast_name>Antonia Vukmirović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-1360</code><acronim><![CDATA[]]></acronim><duration>20.01.2025 - 21.02.2025</duration><status>U tijeku</status><financ_value>2.805,00 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Šumarstvo, </scie_field_hr><scie_field_en>Forestry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet šumarstva i drvne tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Forestry and Wood Technology]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Asistentica djeluje u okviru znanstveno-istraživačke grupe na projektu Hrvatske zaklade za znanost „Fenotipski odgovor provenijencija obične bukve i hrasta kitnjaka na dugotrajnu sušu u interakciji s različitom koncentracijom fosfora u tlu (Phenolnter)” na Fakultetu šumarstva i drvne tehnologije Sveučilišta u Zagrebu. Istraživački fokus joj je tolerancija biljaka na stres, prije svega stres uzrokovan sušom, u području biljne fiziologije. U sklopu znanstveno-istraživačkog usavršavanja, asistentica će se baviti analizom utjecaja ektomikorize na fluorescenciju klorofila (svjetlosne reakcije fotosinteze) kod sadnica hrasta lužnjaka izloženih suši i pepelnici. Nadalje, istraživat će kako suša i toplinski stres utječu na fiziološka, morfološka i anatomska svojstva različitih provenijencija obične bukve. Treći fokus bit će na prilagodbi različitih vrsta hrastova na sušni stres. Ova istraživanja su važna zbog sve učestalijih suša uzrokovanih klimatskim promjenama koje negativno utječu na vitalnost i razvoj šumskog drveća. Asistentica će steći nova znanja o fiziološkim mehanizmima prilagodbe drveća na stresove, što će primijeniti u svojoj doktorskoj disertaciji i budućim projektima. Osim toga, proširit će svoje razumijevanje o ulozi ektomikoriznih gljiva u otpornosti drveća na stres i istražiti prilagodbu drveća na biotske i abiotske stresove. Radit će u interdisciplinarnom istraživačkom okruženju, a sve to će joj omogućiti bolje razumijevanje problematike kojom se bavi te pisanje kvalitetnijih i sveobuhvatnijih publikacija i, u konačnici, doktorske disertacije.Organizacija-domaćin: Institut za nizijsko šumarstvo i životnu sredinu, Sveučilište u Novom Sadu, Srbija]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16397</id><title_hr><![CDATA[Utjecaj promjene klime, korištenja zemljišta i poljoprivredne prakse na pojavu i ponašanje zagađivala u savskom prekograničnom vodonosniku]]></title_hr><title_en><![CDATA[Impact of climate change, land use and agricultural practice changes on the occurrence and fate of contaminants in the Sava transboundary aquifer ]]></title_en><user_id>5602</user_id><user_firstLast_name>Ozren Larva</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>WEAVE</proposal_type><proposal_call>2024</proposal_call><code>WEAVE-2024-5367</code><acronim><![CDATA[GWQualityPath2070]]></acronim><duration>01.02.2025 - 31.01.2028</duration><status>U tijeku</status><financ_value>120.251,67 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Rudarstvo, nafta i geološko inženjerstvo, </scie_field_hr><scie_field_en>Mining, petroleum and geological engineering, </scie_field_en><institution_hr><![CDATA[Hrvatski geološki institut]]></institution_hr><institution_en><![CDATA[Croatian Geological Survey]]></institution_en><team_members_id>3694, 1159, 873045, </team_members_id><team_members_names><![CDATA[Željka Brkić, Jadranka Barešić, Rahela Šanjek, ]]></team_members_names><keywords_hr><![CDATA[nova onečišćivala, poljoprivredno opterećenje, distribucija starosti podzemne vode, numeričko modeliranje, klimatske promjene, nesigurnosti]]></keywords_hr><keywords_en><![CDATA[emerging contaminants, agricultural load, groundwater age distribution, numerical modelling, climate change, uncertainties ]]></keywords_en><summary_hr><![CDATA[Glavni cilj predloženog projekta je povećati razumijevanje sudbine onečišćujućih tvari poljoprivrednog podrijetla u prekograničnom savskom vodonosnom sustavu koji se proteže od Krškog do Zagreba. Koristit će se različite istraživačke tehnike i metode u sklopu terenskih istraživanja, uzorkovanja podzemnih voda, interpretacije laboratorijskih analiza uzoraka podzemnih voda i numeričkog modeliranja. Terenskim istraživanjima će se identificirati opažačke bušotine prikladne za uzorkovanje podzemnih voda, a uzorkovanje podzemnih voda provodit će se odgovarajućim tehnikama potrebnim za ciljanu laboratorijsku analizu. Interpretacija podataka o prisutnosti određenih onečišćujućih tvari u podzemnim vodama, rezultata testova procjeđivanja vode i pronosa tvari u lizimetrima, procjena starosti podzemne vode, te analiza utjecaja različitih scenarija klimatskih promjena i različitih poljoprivrednih praksi na podzemne vode korištenjem modela toka podzemne vode i pronosa otopljenih tvari, bit će dio kabinetskog rada. Nadalje, ispitat će se nesigurnost rezultata modeliranja. Klimatski scenariji propagirat će se kroz numeričke modele toka podzemne vode i pronosa otopljenih tvari, te će omogućiti identifikaciju dugoročnih trendova koncentracija dušikovih spojeva u podzemnim vodama u uvjetima klimatskih promjena.Očekuje se postizanje sljedećih ciljeva: i) identifikacija glavnih izvora nitrata i pesticida u podzemnoj vodi, ii) identifikacija mjera za preokret trenda onečišćenja podzemne vode uzrokovanog poljoprivredom i metodologije za učinkovitu procjenu provedenih mjera, iii) poboljšanje postojećeg modela obnavljanja podzemnih voda, iv) procjena unosa dušika i pesticida iz poljoprivrednog zemljišta u podzemne vode i evolucije nitrata u vodonosniku, v) procjena utjecaja korištenja zemljišta i klimatskih promjena na dinamiku i kakvoću podzemnih voda i vi) utvrđivanje glavnih izvora nesigurnosti vezanih uz procjenu utjecaja klimatskih promjena.]]></summary_hr><summary_en><![CDATA[The main goal of the proposed project is to increase the understanding of the fate of pollutants of agricultural origin in the transboundary Sava aquifer system, which extends from Krško to Zagreb. Different investigation techniques and methods will be utilised in field investigation, groundwater sampling, interpretation of laboratory analyses of groundwater samples and numerical modelling. Field investigations will be performed to identify suitable observation wells for groundwater sampling campaigns and groundwater sampling will be carried out using the appropriate techniques required for the targeted laboratory analysis. Interpretation of data on the presence of certain pollutants in groundwater, the results of leakage tests on lysimeters, groundwater age assessment, and the analysis of the impact of both different climate change scenarios and various agricultural practices on groundwater resources using groundwater flow and solute transport modelling, will be part of cabinet work. Furthermore, the uncertainty of modelling results will be investigated. The climate scenarios will be propagated in numerical groundwater flow and solute transport models and will enable the identification of long-term trends in concentrations of nitrogen species in groundwater under climate change.The following objectives are expected to be achieved: i) identification of the main sources of nitrates and pesticides in groundwater, ii) identification of the measures to reverse the trend in groundwater pollution from agriculture and methodology for effective evaluation of implemented measures, iii) improvement of the existing groundwater recharge model, iv) estimation of nitrogen and pesticide loads from agricultural land to groundwater and the evolution of nitrates in groundwater, v) assessment of the impact of land use and climate change on groundwater dynamics and quality and vi) identification of the main sources of uncertainty related to the assessment of climate change impacts.]]></summary_en></project><project>
<id>16400</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Sara Melkić]]></title_hr><title_en><![CDATA[]]></title_en><user_id>866595</user_id><user_firstLast_name>Sara Melkić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-9911</code><acronim><![CDATA[]]></acronim><duration>02.09.2024 - 20.12.2024</duration><status>U tijeku</status><financ_value>9.350,00 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, </scie_field_hr><scie_field_en>Economy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Ekonomski fakultet u Zagrebu]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Economics and Business]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Poslovna okolina postala je nepredvidiva, dinamika promjena ubrzana, resursi nikad oskudniji, a očekivanja i konkurirajući zahtjevi koji se stavljaju pred organizacije sve izraženiji (Hernaus, 2025, ). Današnje organizacije obojane su paradoksalnim situacijama, a njihovi menadžeri nastoje ostvariti ravnotežu između suprotstavljenih praksi (npr. poslovati globalno ostvarujući ekonomiju razmjera uz uvažavanje lokalnih specifičnosti, istovremeno razvijati inovativne proizvode/usluge za nova tržišta i efikasno kontrolirati operacije vezane uz plasman postojećih proizvoda/usluga) ne bi li se time izbjegla suboptimalna (kompromisna) rješenja. lako je riječ o vrlo važnim menadžerskim izazovima s kojima se hrvatske organizacije svakodnevno suočavaju, postojeće razumijevanje i znanja kako upravljati organizacijskim paradoksima nisu dostatna. Unatoč činjenici da sve veći broj istraživača u svijetu proučava organizacijske paradokse, u Republici Hrvatskoj ta tema je tek u povojima i zaslužuje veću pozornost znanstvene i stručne javnosti.Kako bismo premostili jaz između hrvatske i najbolje europske prakse, potrebno je najprije razviti istraživačke kompetencije (mladih) znanstvenika, koji će onda biti osposobljeni provoditi svjetski i nacionalno relevantna znanstvena istraživanja. Financiranje lstraživačkog projekta MULTIORGDUAL (2021 - 2025, voditelj: prof. dr. sc. Tomislav Hernaus) i zapošljavanjem asistentice Sare Melkić u sklopu Projekta razvoja karijera mladih istraživača – izobrazba novih doktora znanosti (mentor prof. dr. sc. Tomislav Hernaus) stvoreni su preduvjeti fokusiranog proučavanja problematike organizacijskih paradoksa. Mogućnost daljnjeg znanstveno-istraživačkog usavršavanja asistentice Sare Melkić na Nova SBE pod mentorstvom prof. dr. sc. Miguela Pina e Cunhe, vodećeg europskog istraživača na temu organizacijskih paradoksa značajno će pospješiti dosadašnja višegodišnja nastojanja razvoja hrvatskih istraživačkih kapaciteta i stavljanja istih u funkciju razvoja hrvatskog gospodarstva. Štoviše, ne samo da će zahvaljujući odlaznoj mobilnosti doktorsko istraživanje Sare Melkić i planirana diseminacija rezultata biti kvalitetniji, nego će posljedično biti izgrađen i socijalni kapital kao osnova za nastavak zajedničke suradnje sa svjetski priznatim znanstvenicima.Očekivani znanstveni učinak, osim kroz veću kvalitetu doktorskog rada uslijed mentorskog rada prof. dr. sc. Miguela Pine e Cunhe, bit će vidljiv i kroz pripremu dva zajednička znanstvena rada, koji će biti poslani na objavu u vodećim međunarodnim znanstvenim časopisima indeksiranima u prvom kvartilu citatne baze podataka Web of Science Core Collection. Jedan od ta dva zajednička rada bit će ujedno i doktorski članak Sare Melkić.Nalazi empirijskog istraživanja, oblikovani kroz znanstvene radove i suradnju s mentorom-domaćinom, bit će dodatno interpretirani kako bi gospodarski subjekti i šira poslovna zajednica imali što veću korist od istih. Specifično, kroz objavu članka u stručnom časopisu Ekonomski znalac, asistentica Sara Melkić će sažeto predstaviti, koristeći razgovorni stil pisanja, glavne poruke koje proizlaze iz rigorozno provedenog empirijskog istraživanja organizacijskih paradoksa. Zainteresirani menadžeri, stručnjaci, zaposlenici i studenti detaljnije će o svemu moći pročitati u uredničkoj knjizi Organizacijski paradoksi (urednici prof. dr. sc. Tomislav Hernaus i Sara Melkić). S obzirom da će se planirani stručni članak i urednička knjiga temeljiti na rezultatima anketnih istraživanja provedenih na uzorcima hrvatskih organizacija (njihovih menadžera i zaposlenika), prezentirani zaključci bit će vrlo aktualni, zanimljivi i korisni domaćoj poslovnoj zajednici.Organizacija-domaćin: NOVA School of Business and Economics, Portugal]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16403</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Lana Lebo]]></title_hr><title_en><![CDATA[]]></title_en><user_id>867653</user_id><user_firstLast_name>Lana Lebo</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-3242</code><acronim><![CDATA[]]></acronim><duration>31.08.2024 - 26.01.2025</duration><status>U tijeku</status><financ_value>12.665,00 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, </scie_field_hr><scie_field_en>Economy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Ekonomski fakultet u Zagrebu]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Economics and Business]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Postoji sve veća zabrinutost zbog utjecaja određenih kemikalija na zdravlje, posebno jer mogu ometati rad našeg hormonalnog sustava. Takve kemikalije nalaze se u svim proizvodima na tržištu, a poznate su kao endokrini disruptori (engl. endocrine disrupting chemicals - EDC). EDC su posvuda: u hrani kao pesticidi, u pakiranju i igračkama kao bisfenoli i ftalati te u proizvodima za osobnu njegu kao parabeni. EDC se povezuju s raznim zdravstvenim problemima poput neplodnosti, većeg rizika od razvoja određenih vrsta raka i veću učestalost pretilosti. Kako sve više ljudi dolazi u kontakt s EDC, važno je da se znanstvenici iz područja zdravstva udruže s onima iz društvenih znanosti. Društvene znanosti igraju važnu ulogu u tome kako razumijemo i širimo informacije o ovim problemima prema i među ljudima. Asistentica Lana Lebo u svom doktorskom istraživanju želi saznati kako ljudi mijenjaju svoje ponašanje u svrhu donošenja zdravijih i održivijih odluka. U svom istraživanju, asistentica će ispitati koliko su različite metode poticanja ljudi na zdravije izbore učinkovite, posebno se fokusirajući na metode "gurkanja" (engl. nudging) koristeći se posebnim tipom eksperimenta koji pomaže razumjeti kako ljudi donose odluke. S obzirom na to da asistentica na svojoj matičnoj instituciji nema bihevioralni laboratorij niti mogućnost monetarnog nagrađivanja ispitanika, a koji su ključni za istraživanja u području bihevioralne ekonomije, odlazak na usavršavanje na Sveučilište u Aarhusu pospješilo bi kvalitetu i značaj njenog doktorskog istraživanja. Osim toga, usavršavanjem bi asistentica također dobila priliku za korištenje specijaliziranog software-a Ngene, koji se koristi za dizajniranje eksperimenata izbora. Mentorica, izv. prof. dr. sc. Sonja Perković i članovi skupine Department of Management, omogućit će i pomoći asistentici da kvalitetnije obradi podatke u programskom jeziku R, a koje je prikupila tijekom svog istraživanja. Također, asistentica će sudjelovati na međunarodnom projektu Re BIAS koji ispituje bihevioralne intervencijske tehnike s ciljem povećanja percepcije rizika povezanih s EDC sto je usko povezano s temom njenog doktorskog rada. Asistentica se nakon usavršavanja također planira baviti temom bihevioralne ekonomije i EDC-a, te raditi na zajedničkim publikacijama s mentoricom i ostalim međunarodno priznatim znanstvenicima u ovom području. Također, nastojat će predložiti smjernice za podizanje svijesti o problemu EDC-a prisutnih u kozmetičkim i prehrambenim proizvodima na području Republike Hrvatske.Organizacija-domaćin: Aarhus University, Schol of Business and Social Sciences]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16410</id><title_hr><![CDATA[Utjecaj različitih temperaturnih režima na dinamiku domaćina i patogena u slatkovodnim ekosustavima]]></title_hr><title_en><![CDATA[Effects of different temperature regimes on host-pathogen dynamics in freshwater ecosystems]]></title_en><user_id>18946</user_id><user_firstLast_name>Ana Bielen</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>WEAVE</proposal_type><proposal_call>2024</proposal_call><code>WEAVE-2024-6513</code><acronim><![CDATA[DRoP]]></acronim><duration>01.06.2024 - 31.05.2028</duration><status>U tijeku</status><financ_value>191.268,84 eur</financ_value><scie_area_hr>Interdiciplinarne znanosti, Prirodne znanosti, Biotehničke znanosti, </scie_area_hr><scie_area_en>Interdisciplinary scientific area, Natural sciences, Biotechnical sciences, </scie_area_en><scie_field_hr>Biologija, Biotehnologija, Interdisciplinarne prirodne znanosti, Interdisciplinarne biotehničke znanosti, </scie_field_hr><scie_field_en>Biology, Biotechnology, Interdisciplinary natural sciences, Interdisciplinary biotechnical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Food Technology and Biotechnology]]></institution_en><team_members_id>865411, 865414, 865418, 866741, 866740, 19913, 11179, 25064, 869811, 869699, 867612, 873051, </team_members_id><team_members_names><![CDATA[Heike Schmidt-Posthaus, Simone Pisano, Pamela Nicholson, Gary Delalay, Simone Oberhaensli, Sandra Hudina, Martina Temunovic, Dora Pavić, Ela Šarić, Tin Škugor, BAUDRY Thomas, Karolina Pipinić, ]]></team_members_names><keywords_hr><![CDATA[Aphanomyces astaci, riječni rak, ne-konstantni temperaturni režimi, toplinski val, sekvenciranje RNA, modeliranje]]></keywords_hr><keywords_en><![CDATA[Aphanomyces astaci, noble crayfish, non-constant temperature regime, heat wave, RNA-sequencing, modelling]]></keywords_en><summary_hr><![CDATA[Dinamičan odnos domaćina i patogena ovisi o interakciji između domaćina, patogena i okoliša. Među okolišnim čimbenicima, temperatura snažno utječe na domaćina, patogena i njihovu interakciju. U kontekstu globalnog zatopljenja, temperaturni režimi u slatkovodnim okolištima se mijenjaju, uključujući postupno povećanje prosječne temperature vode i povećanje frekvencije, trajanja i magnitude ekstremnih temperaturnih događaja, kao što su toplinski valovi. Biološki učinci realističnih temperaturnih režima, poput dnevnih temperaturnih fluktuacija i toplinskih valova, do sada su u velikoj mjeri neistraženi. Stoga je naš cilj istražiti učinke različitih temperaturnih režima na dinamiku domaćina i patogena.Kao model koristit ćemo račju kugu, bolest deseteronožnih rakova uzrokovanu patogenom Aphanomyces astaci. Istražit ćemo učinke različitih temperaturnih režima na (1) patogena, (2) domaćina i (3) interakcije domaćina i patogena kombiniranjem različitih pristupa: (i) istraživanjem mehanizama ovisnosti patogena o temperaturi praćenjem preživljenja/rasta i funkcionalne ekspresije gena; (ii) istraživanjem učinka temperature na samog domaćina i interakciju domaćina i patogena putem laboratorijskih infekcijskih pokusa na svim razinama, od ekspresije bolesti do imunosnog odgovora domaćina. Rezultate ćemo sintetizirati primjenom dvije komplementarne vrste modela za predviđanje dinamike bolesti pod različitim temperaturnim režimima: (i) DEB-modeli (engl. Dynamic Energy Budget) za predviđanje kombiniranih učinaka temperature i patogena na metabolizam i rast domaćina, i (ii) modeli distribucije vrsta (engl. Spatial Distribution models, SDMs) za predviđanje promjena u potencijalnoj distribuciji ciljanih vrsta pod različitim temperaturnim scenarijima. Izvodljivost projekta temelji se na bogatoj bazi postojećih preliminarnih podataka i ekspertizama komplementarnog i multidisciplinarnog tima znanstvenika u Hrvatskoj i Švicarskoj.]]></summary_hr><summary_en><![CDATA[Host-pathogen dynamics depends on the interaction between the host, the pathogen and the environment. Amongst environmental factors, temperature strongly impacts the host, the pathogen, and their interaction. In the context of global warming, temperature regimes in freshwater environments are changing, including both gradual increase in the mean water temperature and increase in frequency, duration and magnitude of extreme temperature events, such as heat waves. Biological effects of realistic temperature regimes, like diurnal temperature fluctuations and heat waves, are largely unexplored to date. Thus, we aim to explore the effects of different temperature regimes on host-pathogen dynamics.As a model we will use crayfish plague, a disease of noble crayfish caused by Aphanomyces astaci. To gain an in-depth understanding, we will investigate effects of different temperature regimes on (1) the pathogen, (2) the host and (3) host-pathogen interactions by simultaneously applying and combining different approaches: (i) exploring the mechanisms of pathogen temperature-dependence by investigating the viability/growth and functional gene expression; (ii) exploring the effect of temperature on host alone and host-pathogen interaction by laboratory infection trials at all levels, from disease expression to host immune response. We will synthesize the results by applying two complementary modelling approaches to predict disease dynamics under different temperature regimes: (i) Dynamic Energy Budget (DEB) models to predict the combined effects of temperature and pathogen stress on the host metabolism and growth, and (ii) Species Distribution Models (SDMs) to predict changes in the potential distribution of target species under different temperature scenarios. The feasibility of the project is possible by the solid base of existing preliminary data and the expertise of the established complementary and multidisciplinary team of scientists in Croatia and Switzerland.]]></summary_en></project><project>
<id>16413</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Filip Reščić]]></title_hr><title_en><![CDATA[]]></title_en><user_id>865507</user_id><user_firstLast_name>Filip Reščić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-3229</code><acronim><![CDATA[]]></acronim><duration>16.09.2024 - 31.12.2024</duration><status>U tijeku</status><financ_value>9.095,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Fakultet za fiziku]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Physics]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Zamislite znanstvenu avanturu koja otključava tajne Svemira, gdje se svjetlost prepliće s tkanjem prostor-vremena, otkrivajući nam skrivene aspekte kvantne gravitacije. U svijetu astrofizike, Filip Reščić, doktorski istraživač na Sveučilištu u Rijeci otkriva tajne Svemira koje bi mogle promijeniti naše razumijevanje temeljnih zakona prirode. Njegov rad usredotočen je na jednu od najmisterioznijih vrsta svjetlosti u Svemiru – gama-zrake, koje nose informacije o najekstremnijim događajima daleko izvan Sunčevog sustava. U središtu potrage je kvantna gravitacija, teorija koja teži objediniti silu gravitacije s kvantnom mehanikom, pružajući nam novi uvid u temeljnu strukturu Svemira. Dok zemaljski laboratoriji još uvijek nisu sposobni direktno testirati ovu teoriju, svemir nudi prirodnu arenu za njezino istraživanje kroz promatranje čestica visoke energije, poput gama-zraka.Ovaj ambiciozni projekt vodi nas na put od teorijskih spekulacija do potencijalne eksperimentalne potvrde, koristeći napredne tehnike simulacije razvijene u suradnji s istraživačima Sveučilišta u Padovi. Kroz ove simulacije, istraživač će analizirati putanje gama-zraka, tragajući za neobičnim obrascima koji bi mogli ukazati na utjecaje kvantne gravitacije.Osim što će pružiti novi uvid u strukturu svemira, ovo istraživanje jača veze između istraživačkih timova u Rijeci i Padovi, stvarajući novu platformu za međunarodnu suradnju u istraživanjima koja nadilaze granice našeg planetarnog iskustva. Kroz sudjelovanje u projektu Southern Wide-field Gamma-ray Observatory, ovo istraživanje ne samo da produbljuje naše znanje o svemiru, već i pokazuje kako suradnja može voditi prema otkrićima koja mijenjaju svijet.Organizacija-domaćin: University of Padova, Italija]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16414</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Luka Dornjak]]></title_hr><title_en><![CDATA[]]></title_en><user_id>865015</user_id><user_firstLast_name>Luka Dornjak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-9518</code><acronim><![CDATA[]]></acronim><duration>01.09.2024 - 31.10.2024</duration><status>U tijeku</status><financ_value>5.185,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Kemijsko inženjerstvo, </scie_field_hr><scie_field_en>Chemical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet kemijskog inženjerstva i tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Chemical Engineering and Technology]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Precizno strukturirani biomaterijali predstavljaju prekretnicu u biomedicini i farmaciji. Zahvaljujući visokoj razini kontrole tijekom sinteze, takvi biomaterijali omogućuju stvaranje optimalne podloge za poticanje lokalizirane regeneracije, dostavu lijeka, pa čak i kao nadomjestak tkiva. Kombinacijom ovakvih materijala s bioaktivnom keramikom omogućena je interakcija samog biomaterijala s koštanim tkivom kroz aktivni sloj na površini materijala. Da bi takvi materijali postali komercijalno uspješni, potrebno je omogućiti visoku razinu strukturnih modifikacija i ponovljivosti, uz nisku cijenu same proizvodnje. Metoda 3D biotiskanja predstavlja visokoučinkovitu metodu proizvodnje trodimenzijskih biomaterijala. Osim visoke razine ponovljivosti, omogućena je vrlo precizna konfiguracija same trodimenzijske strukture kako bi se materijal prilagodio traženoj primjeni. Glavni ciljevi predloženog znanstveno-istraživačkog usavršavanja L. Dornjaka bit će priprema, fizikalna i biološka karakterizacija biotinti s inkapsuliranim stanicama prikladnih za 3D biotiskanje okosnica. Predloženo usavršavanje provodit će se u istraživačkoj skupini prof. Alda R. Boccaccinija s University of Erlangen-Nuremberg Institute of Biomaterials, a rezultirat će razvojem bioaktivnih 3D okosnica kao potencijalnih nadomjestaka za koštano tkivo. Ovakva izobrazba rezultirat će transferom stečenih vještina na matičnu instituciju, kao i diseminacijom rezultata na međunarodnoj razini kroz sudjelovanje na konferencijama i objavom rada u međunarodnom časopisu.Organizacija-domaćin: Friedrich-Alexander Universität Erlangen-Nürnberg, Njemačka]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16425</id><title_hr><![CDATA[Odlazna mobilnost asistenata - David Dukić]]></title_hr><title_en><![CDATA[]]></title_en><user_id>867675</user_id><user_firstLast_name>David Dukić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-1312</code><acronim><![CDATA[]]></acronim><duration>05.09.2024 - 05.12.2024</duration><status>U tijeku</status><financ_value>7.735,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[David Dukić, asistent i doktorand na Fakultetu elektrotehnike i računarstva, u svom znanstveno-istraživačkom radu nastoji poboljšati prijenos znanja za rješavanje zadataka označavanja slijeda, klasičnih zadataka područja obrade prirodnoga jezika. Pod mentorstvom prof. dr. sc. Jana Šnajdera istražuje prilagodbu već postojećih, predtreniranih, neuronskih jezičnih modela na zadatke označavanja slijeda kroz uvođenje vanjskog znanja te intervencije u arhitekturu samih modela. Nastavak na dosadašnje istraživanje je primjena kontekstnoga nadziranog učenja kao strategije za bolje prilagođavanje velikih jezičnih modela na zadatke označavanja slijeda. Na znanstveno-istraživačkom usavršavanju, doktorand će surađivati s prof. dr. sc. Goranom Glavašem sa Sveučilišta Julius-Maximilians u Wurzburgu koji može ponuditi ekspertizu u području kojim se doktorand bavi. Doktorand će u sklopu istraživačkog laboratorija CAIDAS (Center for Al and Data Science) gdje djeluje mentor-domaćin imati pristup naprednoj računalnoj infrastrukturi i stručnom mentorstvu mentora-domaćina i njegovih doktoranada te suradnika. Očekuje se da će rezultati ovog istraživanja biti značajni za čitavo područje obrade prirodnog jezika te će biti objavljeni na vodećim međunarodnim konferencijama ili časopisima u tom području.Organizacija-domaćin: Julius-Maximilians-Universität Würzburg, Njemačka]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16426</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Anja Bošnjaković]]></title_hr><title_en><![CDATA[]]></title_en><user_id>867677</user_id><user_firstLast_name>Anja Bošnjaković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-1077</code><acronim><![CDATA[]]></acronim><duration>04.11.2024 - 05.05.2025</duration><status>U tijeku</status><financ_value>15.555,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut za antropologiju]]></institution_hr><institution_en><![CDATA[Institute for Anthropological Research]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Ciljevi doktorskog istraživanja pod nazivom "Identifikacija metaboličkih markera okolišnih utjecaja na zdravlje kemometrijskim metodama i strojnim učenjem" obuhvaćaju identifikaciju metaboličkih biomarkera koji povezuju izloženost okolišnim utjecajima (npr. zagađenju zraka, zagađenje bukom itd.) sa zdravljem putem kemometrijskih metoda i modelima strojnog učenja.U okviru predloženog znanstveno-istraživačkog usavršavanja, fokus će biti na usporedbi metabolomičkih podataka dobivenih kromatografskim analizama uzoraka plazme iz različitih gradijenata onečišćenja. Poseban naglasak će biti stavljen na uzorke izložene specifičnim zagađivačima u usporedbi s uzorcima uzorkovanim s područja gdje izvor zagađenja nije određen. Cilj istraživanja je identificirati razlike u metabolomičkim profilima te razumjeti kako specifični zagađivači utječu na metaboličke procese u plazmi. Analizom razlika u metabolomičkim profilima između različitih skupina ispitanika, nastojat ćemo odgovoriti na pitanja o utjecaju okolišnih čimbenika na zdravlje. Ovaj pristup omogućit će bolje razumijevanje kompleksnih mehanizama koji leže u osnovi okolišno uvjetovanih zdravstvenih ishoda.Organizacija-domaćin: Medicinski fakultet u Grazu, Austrija]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16428</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Marina Oskomić]]></title_hr><title_en><![CDATA[]]></title_en><user_id>866713</user_id><user_firstLast_name>Marina Oskomić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-4788</code><acronim><![CDATA[]]></acronim><duration>09.09.2024 - 09.10.2024</duration><status>U tijeku</status><financ_value>2.635,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Dipeptidil peptidaza 3 (DPP3) je protein čija je prekomjerna ekspresija nađena u raku endometrija, jajnika, pluća, dojke i kolorektalnom karcinomu. U zloćudnim tumorima dojke koji su estrogen-receptor pozitivni povećana ekspresija mRNA DPP3 je u korelaciji s povećanom ekspresijom mRNA gena kontroliranih s transkripcijskim faktorom NRF2 i lošijom prognozom bolesti. U novije vrijeme se DPP3 također ispituje kao potencijalni biomarker lošije prognoze u stanjima kardiovaskularnog šoka. U sklopu predloženog stručnog usavršavanja proučavat će se utjecaj nedostatka proteina DPP3 na ekspresiju ukupne mRNA u stanici, odnosno tzv. stanični transkriptom. S obzirom da su mehanizmi putem kojih DPP3 sudjeluje u različitim patofiziološkim stanjima još uvijek uglavnom nepoznati, istraživanje utjecaja nedostatka proteina DPP3 na ekspresiju mRNA ostalih staničnih gena je bitno za razjašnjavanje njegove potencijalne uloge u razvoju raka i kardiovaskularnih bolesti.Organizacija-domaćin: Institute for Molecular Genetics of Montpellier (IGMM), Francuska]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16434</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Katarina Sokač]]></title_hr><title_en><![CDATA[]]></title_en><user_id>866623</user_id><user_firstLast_name>Katarina Sokač</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-1586</code><acronim><![CDATA[]]></acronim><duration>02.09.2024 - 02.12.2024</duration><status>U tijeku</status><financ_value>7.820,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Kemijsko inženjerstvo, </scie_field_hr><scie_field_en>Chemical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet kemijskog inženjerstva i tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Chemical Engineering and Technology]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Znanstveno-istraživačko usavršavanje usmjereno je na razvoj novih formulacija lijeka dasatiniba koji se koristi u terapiji leukemije. Ovo istraživanje od iznimne je važnosti jer više od 70 % novih lijekova, uključujući i dasatinib, karakterizira niska topljivost u vodenom mediju. Posljedično, ograničena mu je oralna apsorpcija, smanjena bioraspoloživost i terapijska učinkovitost. Cilj usavršavanja je istražiti mogućnost inkapsulacije dasatiniba unutar metalo-organskih mreža kako bi se osigurala kontrola oslobađanja i kontinuirana dostava lijeka u sistemsku cirkulaciju. Metalo-organske mreže imaju poroznu strukturu koja omogućuje učinkovitu inkapsulaciju lijeka, a istovremeno štiti lijek od razgradnje i gubitka aktivnosti. Metalo-organske mreže na bazi cirkonija od interesa su za biomedicinske primjene zbog niske citotoksičnosti, izrazite stabilnosti i jednostavnosti sinteze. Nakon sinteze i karakterizacije pripravljenih kompozita ispitat će se njihova učinkovitost u isporuci lijeka in vitro testovima oslobađanja dasatiniba koji će rezultirati profilima oslobađanja. Nadalje, provest će se testiranja citotoksičnosti i antitumorske aktivnosti formulacija kako bi se procijenila mogućnost njihove primjene u terapiji leukemije. Očekuje se da će rezultati ovog istraživanja doprinijeti poboljšanju bioraspoloživosti dasatiniba i njegovom farmakoterapijskom djelovanju uz smanjenje nuspojava. Navedeno će poboljšati kvalitetu života onkoloških pacijenata. Ovo istraživanje pruža priliku za stjecanje novih znanja i vještina u području farmaceutskog inženjerstva. Također, rezultati ovog istraživanja mogu poslužiti kao osnova za daljnji razvoj istraživačke karijere i suradnje s drugim znanstvenim grupama ili industrijskim partnerima.Organizacija-domaćin: Faculty of Chemical Engineering and Technology, Cracow University of Technology, Poljska]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16438</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Šimun Mandić]]></title_hr><title_en><![CDATA[]]></title_en><user_id>864971</user_id><user_firstLast_name>Šimun Mandić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-4185</code><acronim><![CDATA[]]></acronim><duration>16.09.2024 - 16.12.2024</duration><status>U tijeku</status><financ_value>7.820,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut za fiziku]]></institution_hr><institution_en><![CDATA[Institute of Physics in Zagreb]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[U okviru znanstveno-istraživačkog usavršavanja, kandidat sudjeluje u naprednom programu profesionalnog razvoja, koji se realizira u suradnji između Instituta za fiziku i prestižne istraživačke grupe profesora Carstena Bussea sa Sveučilišta u Siegenu. Ova suradnja, koja se proteže kroz niz godina, rezultirala je objavljivanjem više kvalitetnih znanstvenih radova i zajedničkim sudjelovanjem na međunarodnim konferencijama, te se nastavlja s ciljem daljnjeg unapređenja i diseminacije znanstvenih spoznaja.Tijekom usavršavanja, kandidat će se upustiti u detaljno proučavanje i primjenu naprednih eksperimentalnih tehnika u području sinteze i karakterizacije dvodimenzionalnih materijala, kao što su grafen, MoS2, i WS2, te istraživanja njihovih heterostruktura i funkcionalizacija. Posebna pažnja bit će posvećena interkalaciji i molekularnom samosastavljanju, što otvara nove perspektive u razumijevanju i manipulaciji svojstava ovih materijala za potencijalne primjene u elektronici, optici i drugim tehnološkim područjima.Očekuje se da će rezultati dobiveni tijekom ovog usavršavanja biti objavljeni u visoko rangiranim znanstvenim časopisima, te predstavljeni na međunarodnim znanstvenim skupovima, čime se doprinosi širenju znanstvenih dostignuća. Također, ovaj program će doprinijeti kvaliteti doktorske disertacije kandidata, obogaćujući akademsku zajednicu vrijednim znanstvenim uvidima i potičući daljnje istraživačke aktivnosti u polju materijalnih znanosti.Organizacija-domaćin: Universitat Siegen, Njemačka]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16440</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Marija Polić Pasković]]></title_hr><title_en><![CDATA[]]></title_en><user_id>865042</user_id><user_firstLast_name>Marija Polić Pasković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-3103</code><acronim><![CDATA[]]></acronim><duration>17.09.2024 - 19.03.2025</duration><status>U tijeku</status><financ_value>15.640,00 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Institut za poljoprivredu i turizam]]></institution_hr><institution_en><![CDATA[Institute of Agriculture and Tourism in Poreč]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Maslina (Olea europaea L.) jedna je od vodećih voćnih vrsta na Mediteranu, neodvojivo vezana uz poljoprivredu ali i uz kulturu i religiju zapadne civilizacije. Uz maslinovo ulje i stolne masline, u fokusu novijih znanstvenih istraživanja je list masline koji se osim važne fiziološke uloge za samu biljku, a zbog svojih antioksidativnih svojstava, sve više koristi kao sirovina u različitim granama industrije.Tijekom ovog usavršavanja asistentica će proučavati utjecaj biostimulatora, selena (Se) i silicija (Si), čija je primjena i utjecaj na biljku te distribuciju primarnih ili sekundarnih metabolita u listu masline nedovoljno istražen. Određivanje specifične lokalizacije elemenata na razini tkiva i stanice zahtjeva upotrebu analitičkih state-of-the-art tehnika. Micro-particle-induced X-ray emission (micro-PIXE) jedina je potpuno kvantitativna tehnika koja detektira elemente od natrija (Na) do uranija (U), istovremeno, s osjetljivosti od 1 mg/kg ST (suhe tvari) i lateralnoj rezoluciji ispod jednog µm .Pri tome, lokalizacija glavnih organskih spojeva u poprečnom presjeku lista masline izvršit će se pomoću ATRFTIR mikroskopa i MeV-SIMS-a, metodama koje omogućavaju analiza distribucije molekula na tkivnom nivou.Zatim, isti poprečni presjeci listova bit će analizirani korištenjem mikro-PIXE kako bi se razriješile tkivno-specifične interakcije Se i Si s mineralima u biljkama. ATR-FTIR mikroskop dostupan je na Kemijskom institutu u Ljubljani, a MeV-SIMS i mikro-PIXE na Institutu Jožef Štefan u Ljubljani.Očekivano je da će se razlike u ukupnoj koncentraciji Si i/ili Se u listu masline moći povezati s njihovim različitim koncentracijama u jednom ili više biljnih tkiva te da će alokacija primijenjenog biostimulatora kroz biljna tkiva ponuditi odgovor o njihovim potencijalnim ulogama u biosintezi fenolnih spojeva u listu masline. Nadalje, istraživanje bi trebalo dati odgovor postoji li povezanost primjene istih s promjenama lokalizacije ostalih mikro- i makro-hraniva u listu masline te također da li se postojeće promjene mogu povezati s modulacijom fenolnih komponenata lista između primijenjenih folijarnih tretmana.Organizacija-domaćin: Biotehniška fakulteta, Univerza v Ljubljani, Slovenija]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16442</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Mihaela Pravica]]></title_hr><title_en><![CDATA[]]></title_en><user_id>865158</user_id><user_firstLast_name>Mihaela Pravica</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-3972</code><acronim><![CDATA[]]></acronim><duration>01.09.2024 - 14.02.2024</duration><status>U tijeku</status><financ_value>14.195,00 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Neurodegenerativne bolesti karakterizira nakupljanje agregata pogrešno smotanih proteina, što rezultira progresivnom disfunkcijom neurona i staničnom smrću. lako starenje predstavlja čimbenik u razvoju ovih bolesti, mehanizmi utjecaja starenja na proteostazu nisu u potpunosti razjašnjeni. Dosadašnja istraživanja, koja su se većinom provodila na proliferirajućim stanicama, nedovoljno su istražila mehanizme kontrole kvalitete proteina u stanicama u mirovanju. Korištenje modela starenja stanica kvasca pruža relevantan sustav za proučavanje mehanizama proteostaze. Dosadašnja istraživanja sugeriraju da "shuttle" proteini, poput Dsk2, imaju ključnu ulogu u selektivnoj razgradnji pogrešno smotanih proteina. Cilj predloženog istraživanja je ispitati ulogu ubikvitin-vezujućeg proteina Dsk2 u razgradnji pogrešno smotanih proteina u stanicama kvasca S. cerevisiae u mirovanju. Očekujemo kako će ovo istraživanje razjasniti njegovu ulogu kao ključnog faktora u kontroli kvalitete proteina. Također, očekujemo kako će ovo istraživanje pružiti nove uvide u mehanizme proteostaze, pružiti nova saznanja o ulozi Dsk2 u kontroli kvalitete proteina i doprinijeti razumijevanju mehanizama nastanka neurodegenerativnih bolesti.Organizacija-domaćin: The Wenner-Gren Institute, Stockholm University, Švedska]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16443</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Hrishikesh Kamble]]></title_hr><title_en><![CDATA[]]></title_en><user_id>865275</user_id><user_firstLast_name>Hrishikesh Kamble</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-1623</code><acronim><![CDATA[]]></acronim><duration>31.08.2024 - 30.11.2024</duration><status>U tijeku</status><financ_value>7.820,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Interferencijski višeslojni sustavi građeni od tankih slojeva različitih materijala, najčešće na staklenoj podlozi, imaju široku primjenu kao filtri, antirefleksni slojevi, absorberi, razdjelnici svjetlosnog snopa i drugi optički uređaji. Debljina sloja je razmjerna valnoj duljini spektralnog područja od interesa, te je npr. za infracrveni dio spektra višestruko veća od one koja je potrebna za vidljivi (optički) dio. Pokazano je da se debeli dielektrični slojevi mogu zamijeniti tanjima koji apsorbiraju u danom području valnih duljina. Za ovu svrhu je prikladan sloj metala na granici perkolacije tj. sloj nalik na istrganu nepravilnu mrežu. Takav sloj je moguće dobiti razlaganjem kompaktnog metalnog sloja na staklenoj podlozi uz pomoć električnog polja. Bitno je naglasiti da je ovaj postupak moguć i kada je metal prekriven slojem dielektrika ili uklopljen u višeslojni sustav, što je važno za izradu optičkih uređaja za razne namjene.Dosadašnja istraživanja u Laboratoriju za optiku i optičke tanke slojeve Zavoda za fiziku materijala Instituta Ruđer Bošković su pokazala da se tokom razlaganja električnim poljem mijenjaju indeks loma i/ili debljina dielektričnih slojeva, što utječe na optičke karakteristike cijelog sustava. Naime, te promjene dovode do odstupanja od željenih optičkih svojstava cjelokupnog višeslojnog sustava. Pretpostavlja se da su promjene indeksa loma i/ili debljine dielektričnog sloja posljedica promjena u molekularnoj strukturi sloja, a njihovo razumijevanje je ključno za nastavak razvoja izrade višeslojnih metalo-dielektričnih optičkih uređaja razlaganjem pomoću električnog polja u Laboratoriju koji jedina grupa koja se bavi takvom vrstom primijenjenog istraživanja.U Laboratoriju do sada nisu primjenjivane tehnike za analizu strukturnih promjena materijala pod utjecajem razlaganja primjenom električnog polja, te ne postoji iskustvo na tom području. U Grupi za molekularnu spektroskopiju na Institutu za molekularne znanosti Sveučilišta u Bordeauxu se rade vrlo slična istraživanja promjena u strukturi stakla nastalih djelovanjem električnog polja pri povišenoj temperaturi.Stručno usavršavanje doktoranda upravo u ovoj Grupi je važno za brži i uspješniji nastavak predviđenih istraživanja u Laboratoriju, ali i za planiranje novih projekata i suradnji. Nakon boravka će doktorand moći samostalno raditi odgovarajuća mjerenja na Institutu, uglavnom samostalno analizirati i interpretirati rezultate mjerenja, a stečene vještine i znanja će prenijeti na ostale članove Laboratorija.Organizacija-domaćin: University of Bordeaux - Institut des Sciences Moleculaires, Francuska]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16444</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Tamara Vujović]]></title_hr><title_en><![CDATA[]]></title_en><user_id>865109</user_id><user_firstLast_name>Tamara Vujović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-2369</code><acronim><![CDATA[]]></acronim><duration>16.09.2024 - 31.12.2024</duration><status>U tijeku</status><financ_value>7.565,00 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Interdisciplinarne biotehničke znanosti, </scie_field_hr><scie_field_en>Interdisciplinary biotechnical sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Multipli mijelom predstavlja ozbiljan javnozdravstveni problem, budući da je jedna od najčešćih malignih bolesti krvotvornog sustava. lako je postignut određeni napredak u liječenju primjenom inhibitora proteasoma kao što su bortezomib i karfilzomib, često se javljaju problemi poput recidiva ili razvoja otpornosti na ove lijekove. Stoga su trenutačna istraživanja usmjerena na razvoj novih terapijskih pristupa koji bi poboljšali učinkovitost navedenih lijekova. Jedno od obećavajućih područja istraživanja u tom smislu je primjena prirodnih spojeva kao što su ekstrakti mikroalgi. Preliminarna istraživanja su pokazala značajnu citotoksičnu aktivnost ekstrakata ove mikroalge na stanične linije multiplog mijeloma. Stoga će za vrijeme svog boravka na Sveučilištu u Torinu asistentica Tamara Vujović u suradnji s istraživačkom grupom prof. Roberta Pive raditi na istraživanju mogućnosti primjene ekstrakata i frakcija iz mikroalge Chlamydomonas reinhardtii kao potencijalnog prirodnog izvora inhibitora proteasoma u liječenju multiplog mijeloma. Opći ciljevi ovog znanstveno-istraživačkog usavršavanja uključuju detaljnije ispitivanje učinaka mikroalgalnih ekstrakata i frakcija na stanične linije te provjeru njihove sigurnosti na normalnim stanicama. Također, istraživat će se i mehanizmi putem kojih testirani uzorci uzrokuju smrt malignih stanica. U konačnici, očekuje se da će ovaj rezultati dobiveni tijekom ovog usavršavanja doprinijeti unapređenju terapije koja se primjenjuje u liječenju multiplog mijeloma, odnosno smanjenju nuspojava i smrtnosti kod oboljelih, te obogatiti postojeća znanja o primjeni prirodnih spojeva u liječenju malignih bolesti. Osim navedenog, ovo istraživanje također predstavlja temelj za buduće suradnje s drugim istraživačkim grupama i potencijalno otvara put za razvoj novih terapijskih pristupa.Organizacija-domaćin: Universita degli studi di Torino, Italija]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16445</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Tessa Bauman]]></title_hr><title_en><![CDATA[]]></title_en><user_id>864841</user_id><user_firstLast_name>Tessa Bauman</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-1302</code><acronim><![CDATA[]]></acronim><duration>02.09.2024 - 20.12.2024</duration><status>U tijeku</status><financ_value>9.350,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Istraživački plan asistentice usmjeren je na primjenu algoritama strojnog učenja kako bi se optimizirala strategija financijskih ulaganja. Primjena strojnog učenja u financijama omogućuje analizu velikih skupova podataka kako bi se identificirali uzorci i trendovi koji mogu poboljšati donošenje investicijskih odluka. Između ostalog, ovi algoritmi se koriste za automatsko prilagođavanje ulaganja prema promjenama na tržištu kako bi se pravodobno reagiralo u slučaju rizika od većih financijskih gubitaka. Općeniti zadatak u primjeni strojnog učenja za financijske probleme je što vjernije simulirati financijsku okolinu u kojoj se zbiva trgovanje tj. ulaganje. Naglasak istraživanja, kao i znanstveno-istraživačkog usavršavanja je na primjenama strojnog učenja za ulaganje zasnovano na cilju. Ovu vrstu ulaganja određuje unaprijed zadani financijski cilj koji treba biti ostvaren u unaprijed definiranom vremenskom roku. Primjer ovakvog investiranja je ulaganje za mirovinu. Investitor je svjestan trenutka kada će završiti radni vijek te do tog trenutka želi akumulirati dovoljan kapital kako bi osigurao udobnu mirovinu.Zbog prirode ovog problema, često se uspješnost gleda binarno - je li financijski cilj ostvaren ili nije. Međutim, takva postavka nije realna. Prosječan investitor će razlikovati situaciju u kojoj je blizu svog cilja te onu u kojoj je ulaganje potpuno podbacilo.Nadalje, za realistične simulacije trgovanja potrebno je voditi računa o isplativosti velikih promjena u ulaganjima. Dinamičnost tržišta motivira investitora na brze promjene, no treba procijeniti koliko su usponi i padovi na tržištu dugoročni te, shodno tome, isplati li se značajno prodavati i kupovati druge financijske instrumente. Potencijalni prihod od promjene mora biti veći od troškova koji proizlaze iz trgovanja.Investiranja zasnovana na cilju često uključuju dodatne novčane uplate tijekom perioda ulaganja. Kod modeliranja je zato potrebno uzeti u obzir i novčane tokove koji utječu na ostvarenje cilja. Koristeći metode strojnog učenja poželjno je pronaći optimalni tok uplata koji garantira ostvarenje cilja uz minimalne novčane doprinose.Znanstveno-istraživačko usavršavanje će se fokusirati na integraciju navedenih problema u model strojnog učenja za ulaganje zasnovano na cilju. Rezultati se planiraju objaviti u sklopu konferencijskog rada te će se prikazati usporedba predloženog modela sa standardnim modelima.Organizacija-domaćin: Universidad Carlos III de Madrid, Španjolska]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16446</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Iva Vukojević]]></title_hr><title_en><![CDATA[]]></title_en><user_id>29531</user_id><user_firstLast_name>Iva Vukojević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-1917</code><acronim><![CDATA[]]></acronim><duration>20.08.2024 - 19.02.2025</duration><status>U tijeku</status><financ_value>15.640,00 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Psihologija, </scie_field_hr><scie_field_en>Psychology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Ljudi vlastite izjave modificiraju na razne načine, primjerice, uporabom riječi, izraza i konstrukcija koje služe pojačavanju i ublažavanju izrečenog. Recimo, možemo čuti osobu koja kaže da je „ponekad lijena kada se ne naspava“. Ono što mi postavljamo kao pitanje jest što možemo saznati o psihološkim karakteristikama ljudi samo na temelju načina na koji su nešto napisali, tj. toga koliko su opis sebe ublažili ili pojačali. Pretpostavljamo da je pojačavanje opisa vlastitih pozitivnih karakteristika vezano uz mehanizam samouzdizanja kojim ljudi unaprjeđuju viđenje sebe (npr. Ja sam jako pozitivna osoba), dok je ublažavanje vlastitih negativnih karakteristika vezano uz mehanizam samozaštite kojim se ljudi štite od negativnog viđenja sebe (npr. Ponekad sam lijena, kada se ne naspavam). U istraživanju ovog doktorskog rada vežemo opisano jezično izražavanje s raznim psihološkim karakteristikama s kojima bi ono teorijski trebalo biti povezano. Npr. jesu li ljudi koji su depresivniji manje skloni ublažavati vlastite negativne karakteristike? Jesu li ljudi koji su narcisoidniji više skloni pojačavati vlastite pozitivne karakteristike?Samo usavršavanje bavit će se temom kako samo na temelju teksta, s naglaskom na jezične grupe pojačivača i ublaživača, predvidjeti nečije psihološke karakteristike obuhvaćene ovom disertacijom (narcizam, depresivnost, samopoštovanje, ekstraverzija). Odgovor na to pitanje dat će metode umjetne inteligencije razvijene za obradu teksta. Asistentica će na usavršavanju učiti o tim metodama i kako ih primijeniti te će ih iskoristiti za analizu podataka iz svog doktorskog rada. No, kako bi došla do odgovora koji su točno jezični signali doveli do točnog predviđanja neke psihološke karakteristike, potrebno je provesti dodatne analize. Mentorica-domaćin je psihologinja i stručnjakinja u primjeni modela umjetne inteligencije upravo na transparentan način koji nam omogućava saznati što su točno modeli koristili u svojoj predikciji. Ovaj korak je važan jer samo takvim, transparentnim, pristupom možemo razviti uistinu valjanu interdisciplinarnu povezanost između psihologije i umjetne inteligencije.Organizacija-domaćin: Copenhagen Center for Social Data Science (SODAS), University of Copenhagen, Danska]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16450</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Sherif Kamal]]></title_hr><title_en><![CDATA[]]></title_en><user_id>866641</user_id><user_firstLast_name>Sherif Kamal</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-9676</code><acronim><![CDATA[]]></acronim><duration>02.09.2024 - 31.10.2024</duration><status>U tijeku</status><financ_value>5.100,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut za fiziku]]></institution_hr><institution_en><![CDATA[Institute of Physics in Zagreb]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[2D materijali, nano-sistemi debljine od svega nekoliko atoma, se nalaze u fokusu znanstvene zajednice zbog brojnih naprednih fizikalnih i kemijskih svojstava koja pak obećavaju njihove razne visokotehnološke primjene. Relativno novi član te obitelji 2D materijala je i borofen, odnosno materijal koji čine atomi bora povezani u planarnu mrežu i koji se odlikuje visokom električnom i toplinskom vodljivošću kao i dobrim mehaničkim svojstvima. Unatoč značajnim znanstvenim naporima, mnoga svojstva borofena i dalje nisu detaljno istražena, što uključuje i razumijevanje interakcije borofena s drugim materijalima odnosno drugim atomima i molekulama. Sa svrhom adresiranja ovog otvorenog pitanja, ovim usavršavanjem će se istražiti dekoracija borofena s nekoliko odabranih atoma (Li, Na) i molekula (Hz, Oz) kao reprezentativnih sustava za dobivanje uvida u relevantne atomske odnosno molekularne interakcije i procese. Na temelju dobivenih fundamentalnih znanja moći će se predvidjeti ponašanje borofena u kompleksnijim sistemima i uređajima. što će pak dati smjernice za daljnje istraživanje borofena i njegovih primjena.Organizacija-domaćin: University of Twente, Nizozemska]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16453</id><title_hr><![CDATA[Natura historiae, historia naturae: razotkrivanje povjesnosti prirode putem rano novovjekovnih analiza kontinuiteta, vremena i ljudske povijesti]]></title_hr><title_en><![CDATA[Natura historiae, historia naturae: Unveiling Nature&#39;s Historicity through Early Modern Analyses of Continuity, Time, and Human History]]></title_en><user_id>3152</user_id><user_firstLast_name>Luka Boršić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>WEAVE</proposal_type><proposal_call>2024</proposal_call><code>WEAVE-2024-3637</code><acronim><![CDATA[NHHN]]></acronim><duration>01.04.2025 - 31.03.2028</duration><status>U tijeku</status><financ_value>46.563,00 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filozofija, </scie_field_hr><scie_field_en>Philosophy, </scie_field_en><institution_hr><![CDATA[Institut za filozofiju]]></institution_hr><institution_en><![CDATA[Institute for Philosophy in Zagreb]]></institution_en><team_members_id>2634, 3206, </team_members_id><team_members_names><![CDATA[Ivana Skuhala Karasman, Boris Kožnjak, ]]></team_members_names><keywords_hr><![CDATA[kontinuum, stratigrafija, priroda, vrijeme, povijest, povjesnost]]></keywords_hr><keywords_en><![CDATA[continuum, stratigraphy, nature, time, history, historicity]]></keywords_en><summary_hr><![CDATA[Projekt se fokusira na proučavanje logičkih i epistemoloških aspekata pojma povijesti prirode unutar okvira nastanka geometrijski orijentirane prirodne znanosti i mehanističke filozofije. Istraživanje proizlazi iz renesansne tradicije &#39;&#39;historia naturalis&#39;&#39;, posebno njezine usredotočenosti na porijeklo prirodnih entiteta. Glavna točka je analiza dijakronije prirode na temelju odnosa između principa kontinuiteta i stratigrafije te naknadne analize principa stratigrafije kao geometrijskog ideala. Rezultirajući pojam &#39;&#39;konkretnog vremena&#39;&#39; služi kao alat za analizu konvergencije ili presjeka ljudske povijesti i povijesti prirode.]]></summary_hr><summary_en><![CDATA[The project focuses on examining the logical and epistemological aspects of the notion of history of nature within the framework of the emergence of geometric natural science and mechanistic philosophy. The research stems from the Renaissance tradition of historia naturalis, particularly its focus on the origin of natural entities. Its central point is then the analysis of the diachrony of nature on the basis of the relationship between the principles of continuity and stratigraphy and the subsequent analysis of the principle of stratigraphy as a geometric ideal. The resulting notion of “concrete time” serves as a tool for analyzing the convergence or intersection of human history and history of nature.]]></summary_en></project><project>
<id>16454</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Petra Drašković]]></title_hr><title_en><![CDATA[]]></title_en><user_id>865405</user_id><user_firstLast_name>Petra Drašković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-8326</code><acronim><![CDATA[]]></acronim><duration>01.08.2024 - 30.11.2024</duration><status>U tijeku</status><financ_value>10.370,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Sudionici na tržištu električne energije mogu zauzeti dvije uloge — preuzimatelja i davatelja cijena. Preuzimatelji cijena zbog svog niskog tržišnog udjela ne mogu utjecati na cijene već ju moraju prihvatiti i svoj rad prilagoditi tržišnim potrebama. Zbog toga se obnovljivi izvori energije, koje karakterizira nedostatak fleksibilnosti uparuju s drugim fleksibilnim tehnologijama, poput baterija i elektrolizatora, kako bi povećali svoju fleksibilnost. U takvim hibridnim postrojenjima, fleksibilne tehnologije omogućavaju zaglađivanje krivulje proizvodnje te arbitražu. Davatelji cijena, zbog svog dovoljno visokog tržišnog udjela, mogu utjecati na cijene. U tom slučaju modeli uključuju višerazinsku optimizaciju u kojima se simulira pogonski model postrojenja, ali i čišćenje tržišta. Kako bi se simuliralo čišćenje tržišta primjenjuju se optimalni tokovi snaga i plina, koji zbog svoje nekonveksnosti i nelinearnosti predstavljaju značajan problem za takve modele. Cilj usavršavanja je razviti matematičke modele pojedinog dijela hibridnog postrojenja s naglaskom na vodikove tehnologije koji će biti korišteni kao dio optimizacijskih problema koji razmatraju sudjelovanje ovakvih postrojenja na tržištima električne energije i vodika.Organizacija-domaćin: Technical University of Denmark, Kopenhagen]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16456</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Matija Matijević]]></title_hr><title_en><![CDATA[]]></title_en><user_id>867700</user_id><user_firstLast_name>Matija Matijević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-5171</code><acronim><![CDATA[]]></acronim><duration>20.09.2024 - 06.12.2024</duration><status>U tijeku</status><financ_value>6.630,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Kvantni centri boje su jedinstvene kvantne čestice smještene unutar kristalne strukture dijamanta, koje posjeduju jedinstvene osobine koje bi mogle imati vrlo važan utjecaj na razvoj kvantne tehnologije. Jedan od načina na koji se kvantni centri mogu proizvesti je ionska implantacija koja je tema ovog istraživanja i koja će se napraviti koristeći ione dobivene iz akceleratora na Institutu Ruđer Bošković. Implantirani uzorci prvo će se karakterizirati korištenjem optičkih metoda koje su u tu svrhu razvijene na Sveučilištu u Torinu. Najvažnije svojstvo kvantnih centara je da se njihovim kvantnim stanjem može upravljati te ga se može očitavati pomoću optičkih signala. Stoga je otkrivanje i razumijevanje njihovih optičkih svojstava nužno za bolje razumijevanje njihovog kvantnog ponašanja, što otvara mogućnosti razvoja naprednih kvantnih sustava, kao što su kvantno računarstvo i kvantna komunikacija. Važno je napomenuti da stečena znanja o kvantnim centrima u ovom istraživanju mogu biti iskorištena u poboljšanju osjetljivosti senzora, razvoju precizne medicinske dijagnostike i stvaranju efikasnijih energetskih sustava. U zaključku, ovo istraživanje na temu kvantnih centara boje u dijamantu i njihove optičke karakterizacije pružit će uvid u fascinantan svijet kvantnih čestica i potencijalno omogućiti primjene u različitim područjima tehnologije te pomoći u razvoju inovativnih kvantnih tehnologija koje će oblikovati našu budućnost.Organizacija-domaćin: Universita degli studi di Torino, Italija]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16459</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Krešimir Burnać Burnać]]></title_hr><title_en><![CDATA[]]></title_en><user_id>865133</user_id><user_firstLast_name>Krešimir Burnać Burnać</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-3601</code><acronim><![CDATA[]]></acronim><duration>10.09.2024 - 11.10.2024</duration><status>U tijeku</status><financ_value>2.720,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Građevinarstvo, </scie_field_hr><scie_field_en>Civil engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Građevinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Civil Engineering]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[U sklopu usavršavanja detaljno će se istražiti uzroci i posljedice povišenih vibracija na kolosijeku koje nastaju kao rezultat nepravilnosti i oštećenja na voznoj površini tračnica te će se istražiti metode za njihovu detekciju i evaluaciju, koristeći podatke o vibracijama vozila. Fokus istraživanja stavljen je na naboranost kao čestu pojavu koja se javlja posebno na tramvajskim kolosijecima, istražujući njezinu pojavu i utjecaj na udobnost vožnje i razinu vibracija u vozilu. Istraženi su različiti pristupi analizi neravnosti vozne površine tračnica, uključujući direktne i indirektne metode, uz zaključak da se kod indirektnih metoda, osim signala vibracija, moraju analizirati i dinamičke karakteristike vozila i kolosiječne konstrukcije, kako bi se dobili što točniji podaci o stanju vozne površine tračnice. Usavršavanje se može podijeliti u tri faze: pregled stanja područja, kampanja mjerenja na tramvajskoj mreži u Poznanu (neravnost vozne površine tračnice, vibro-akustički parametri vozila i kotača, vibracije vozila), te obrada i tumačenje rezultata. Nakon odrađenog usavršavanja, asistent bi trebao savladati metode i metodologije ispitivanja i obrade podataka koje će moći primijeniti na mreži tramvajskih kolosijeka u Zagrebu, te iskoristiti rezultate oba mjerenja kao temelj za izradu doktorske disertacije i članka za časopis velikog faktora odjeka.Organizacija-domaćin: Poznan University of Technology, Poljska]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>16464</id><title_hr><![CDATA[Primjena nove generacije glikomimetika u liječenju neurodegenerativnih bolesti: napredna biološka analiza (GlycoDrug)]]></title_hr><title_en><![CDATA[Advanced Glycomimetics for the Treatment of Age-Related Neurodegenerative Disorders: A Complex Biological Exploration (GlycoDrug)]]></title_en><user_id>12653</user_id><user_firstLast_name>Dinko Mitrečić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>WEAVE</proposal_type><proposal_call>2024</proposal_call><code>WEAVE-2024-6631</code><acronim><![CDATA[GlycoDrug]]></acronim><duration>01.04.2025 - 31.03.2028</duration><status>U tijeku</status><financ_value>197.000,00 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>12687, 858430, 865632, 858356, 22595, 19170, 6226, 867716, 19920, 867726, 865886, </team_members_id><team_members_names><![CDATA[Ivan Alić, Ana Bekavac, Ante Plećaš Plećaš, Paula Stančin, Sandra Grgić, Jure Krasić, Marina Radmilović (Dobrivojević), Iva Šimunić, Anton Glasnović, Sandra Kunštek, Jasmina Isaković, ]]></team_members_names><keywords_hr><![CDATA[Alzheimerova demencija, glikobiologija, inhibitor glukozaminidaze, organoidi mozga, tau mišji model demencije]]></keywords_hr><keywords_en><![CDATA[Alzheimer`s dementia, Glycobiology, Inhibitor of Glucosaminidase, Brain Organoid, tau-protein based mouse model of dementia]]></keywords_en><summary_hr><![CDATA[Alzheimerova bolest (AD) predstavlja veliki izazov za zdravlje i socio-ekonomske sustave cijelog svijeta. Selektivna inhibicija O-GlcNAC-aze dovodi do povećanja O-GlcNAc-modificiranih Tau proteina, čime se smanjuje njihova hiperfosforilacija, a time i neurodegeneracija, odnosno odumiranje neurona. Ovaj hrvatsko-češki projekt će istražiti te optimizirati novodizajnirane molekule karbacikličke strukture, koje su nastale nedavnom suradnjom naših institucija. Analize učinka ovih molekula će uključivati napredne in vitro i in vivo metode kojima ćemo procjeniti učinkovitost u ublažavanju neurodegeneracije živčanih stanica, a fino podešavanje molekularne strukture će dovesti do optimizacije njihovih farmakoloških svojstava. Testirati će se efikasnost prolaska ovih molekula kroz krvno-moždanu barijeru (BBB), stupanj inhibicije OGA, stupanj pojačavanja O-GlcNAcilacije, smanjenje fosforilacije Tau-proteina te stupanj smanjenja neurodegeneracije. U tu svrhu će se koristiti napredni biološki modeli, koji uključuju statički i dinamički model krvno moždane barijere, određivanje inhibicije fosforilacije Tau u modelu Alzheimerove bolesti temeljenom na organoidima ljudskog mozga, te istraživanje učinkovitosti na in vivo mišjem taupatskom modelu demencije.]]></summary_hr><summary_en><![CDATA[Alzheimer&#39;s disease (AD) poses a major challenge to both health and the socio-economic landscape. Selective inhibition of O-GlcNAC-ase leads to an increase in O-GlcNAc-modified Tau protein, thereby curbing its hyperphosphorylation and attenuating neurodegeneration. The Croatian-Czech project aims to comprehensively evaluate newly designed five-membered carbacyclic lead structures, derived from recent collaboration through rigorous biological assays and to optimize this lead structure. Evaluations will include advanced in vitro and in vivo studies to assess efficacy in attenuating neurodegeneration and refine structural features for optimalpharmacologic performance. These glycodrugs will be tested for passing the blood-brain barrier (BBB), inhibiting OGA, enhancing O-GlcNAcylation, and alleviating Tau-protein phosphorylation and neurodegeneration in advanced biological models, which include static and dynamic BBB models, evaluation of Tau phosphorylation inhibition in a human AD model using cerebral organoids, and investigation of efficacy in an in vivo tauopathic mouse model.]]></summary_en></project><project>
<id>16470</id><title_hr><![CDATA[Suradna čovjek-robot manipulacija koja razmatra geometriju i nesigurnost]]></title_hr><title_en><![CDATA[Human-robot collaborative manipulation by considering geometry and uncertainty]]></title_en><user_id>4132</user_id><user_firstLast_name>Ivan Marković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>WEAVE</proposal_type><proposal_call>2024</proposal_call><code>WEAVE-2024-2439</code><acronim><![CDATA[HORACE]]></acronim><duration>01.12.2024 - 30.11.2028</duration><status>U tijeku</status><financ_value>187.508,47 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, Računarstvo, </scie_field_hr><scie_field_en>Electrical engineering, Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>865708, 378, 869471, 872936, 26969, </team_members_id><team_members_names><![CDATA[Luka Petrović, Ivan Petrović, Borna Paro, Naomi Kombol, Marin Orsic, ]]></team_members_names><keywords_hr><![CDATA[Suradnja čovjek-robot, Riemannove mnogostrukosti, geometrijska algebra, algebra udaljenosti, učenje vještina, humanoidni robot]]></keywords_hr><keywords_en><![CDATA[Human-robot collaboration, Riemmanian manifolds, Geometric algebra, Distance algebra, Skill learning, Humanoid robot]]></keywords_en><summary_hr><![CDATA[Čovječanstvo je kroz povijest razvijalo ingeniozne ideje kako bi proizvelo strojeve koji mogu zamijeniti ljude u ponavljajućim, opasnim i napornim zadacima kako vrijedna ljudska inteligencija ne bi ostala zarobljena u zadacima koje još nismo naučili automatizirati. Nedavni napredak u antropomorfnim robotima i industrijskim manipulatorima s dvije ruke doveo je do povećanog interesa za probleme koji se odnose na dvoručnu manipulaciju i suradnju čovjeka i robota (SČR). Međutim, SČR je suptilan i izazovan iz više aspekata, u rasponu od besprijekorne, sigurne i prirodne fizičke suradnje, gdje se povezani znanstveni problemi kreću od upravljanja niske razine do planiranja i izvršenja zadataka na visokoj razini, pa sve do psiholoških aspekata rada s ljudima. U projektu HORACE razmatramo koordiniranu dvoručnu manipulaciju, konkretno, kada su ruke u fizičkoj interakciji jedna s drugom i čovjekom dok rješavaju isti zadatak. Takvi problemi se mogu u osnovi promatrati kao problemi geometrije i u posljednje vrijeme dosta se je istraživačkog truda posvetilo reprezentaciji i korištenju svojstava geometrije za rješavanje različitih problem učinkovitije. U projektu HORACE istražit ćemo upotrebu različitih geometrijskih deskriptora, zajedno s njihovim probabilističkim proširenjem, kako bismo modelirali varijacije zadatka i nesigurnosti unutar geometrijske karakterizacije zadatka koji treba postići. Predloženim pristupom možemo iskoristiti snagu ovih matematičkih alata te tako poboljšati i otvoriti nova područja za SČR manipulaciju u stvarnom svijetu prožetim neizvjesnošću. Na kraju, HORACE će dovesti do novih metodoloških razvoja koji će proizvesti učinkovitiju suradnju čovjeka i robota te bolje razumijevanje te složene geometrijske strukture.]]></summary_hr><summary_en><![CDATA[Humankind has throughout the history worked in ingenious ways to produce machines that can replace humans in repetitive, dangerous, and arduous tasks so that valuable human intelligence does not lay trapped in tasks we have not yet learned to automate. Recent advances in both anthropomorphic robots and dual-arm industrial manipulators have led to an increased interest in the specific problems pertaining to bimanual manipulation and human-robot collaboration (HRC). However, HRC is subtle and challenging from multiple aspects, ranging from seamless, safe and natural physical collaboration, where the related scientific problems range from low-level control to high level task planning and execution, to psychological aspects of working with humans. In HORACE, we focus on the coordinated bimanual manipulation, specifically on the problems when arms are physically interacting with one another and with a human while solving the same task. Such problems can be viewed fundamentally as problems of geometry, and a lot of recent research effort is dedicated to representing and utilizing these geometric properties for solving a wider variety of problems more efficiently. In HORACE, we will explore the use of varied geometric descriptors together with their probabilistic extension, since working with humans inherently includes stochasticity, in order to model task variations and uncertainty within a geometric characterization of the tasks to achieve. With the proposed approach we can harness the power of these mathematical representations, thus enhance and open new venues for HRC manipulation in real world scenarios riddled with uncertainty.  In the end, HORACE will lead to novel methodological developments yielding more efficient human-robot collaboration and better understanding of the complex geometrical structure of human-robot collaboration.]]></summary_en></project><project>
<id>16503</id><title_hr><![CDATA[Chemical and pressure engineering of cobaltite-based perovskites]]></title_hr><title_en><![CDATA[Kemijski i tlačni inženjering perovskita na bazi kobalta]]></title_en><user_id>13002</user_id><user_firstLast_name>Martina Vrankić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>WEAVE</proposal_type><proposal_call>2024</proposal_call><code>WEAVE-2024-8873</code><acronim><![CDATA[CePrECiPe]]></acronim><duration>01.04.2025 - 31.03.2028</duration><status>U tijeku</status><financ_value>197.404,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, Fizika, </scie_field_hr><scie_field_en>Chemistry, Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>11146, 12971, 12831, 867690, 872992, </team_members_id><team_members_names><![CDATA[Jasminka Popović, Lidija Androš Dubraja, Marijana Jurić, Takeshi Nakagawa, Dora Balen, ]]></team_members_names><keywords_hr><![CDATA[kobaltovi perovskiti; dopiranje, mehanokemija, kemijsko inženjerstvo, tlačno inženjerstvo, odnos struktura-svojstvo na visokom tlaku]]></keywords_hr><keywords_en><![CDATA[Cobaltite-based perovskites, doping, mechanochemistry, chemical engineering, pressure engineering, high pressure structure-property relationship]]></keywords_en><summary_hr><![CDATA[Kobaltni oksidi tipa perovskita atraktivni su spojevi za fotonaponske uređaje, katalizatore, termoelektrike, baterije, superkondenzatore i uređaje za pohranu. Jedinstvena kemijska, fizikalna i mehanička svojstva rezultat su prilagodljivosti njihove kristalne strukture, koja se može podesiti kemijskim inženjerstvom (npr. dopiranjem) i/ili post-sintetskim tretmanom pod visokim tlakom. Sinergija saznanja o sintezi ovih materijala, te njihovog odgovora na kompresiju/dekompresiju, omogućiti će razumijevanje sprege struktura-svojstvo pri visokim tlakovima. Projektni prijedlog ima za cilj stjecanje komplementarnog znanja o odnosu putova sinteze perovskita na bazi kobalta (LaXCa1-XCoyM1-yO3-d (M = Ni, Co, Cr, Fe, x = 0.1-0.5; y = 0.1-1.0) i rasvjetljavanja njihovih fundamentalnih kristalografskih i fizikalno-kemijskih svojstava. Za dobivanje različitih morfologija i kemijskih struktura koristiti će se sol-gel, koprecipitacija i mehanokemija, dok će se kristalne strukture i fazne stabilnosti podešavati strategijom dopiranja. Proučiti će se utjecaj konvencionalnog sinteriranja, te taloženja u plazmi na transformacije kristalnih struktura, te njihove termoelektrične, elektrokatalitičke i kemokatalitičke funkcionalnosti. Pored kemijskog inženjerstva, hidrostatski tlak će se koristiti kao čisti alat za podešavanje struktura perovskita i njihovih funkcionalnosti, što može rezultirati nizom, egzotičnih svojstava: sužavanje energijskog procijepa, pojačanje intenziteta fotoluminiscencije, zadržavanje visokotlačne faze pri ambijentalnim uvjetima, metalizacija, amorfizacija i fazni prijelazi. Spektar in situ metoda pri visokom tlaku (rendgenska difrakcija u prahu, Ramanova i apsorpcijska spektroskopija te mjernja električnog otpora) do 50 GPa poboljšat će fundamentalno razumijevanje mehanizma koji leži u sprezi strukture i svojstava perovskita, a koja rasvjetljuju pozadinu iznimnih svojstava kao rezultat primjerene dopiranja i kompresije/dekompresije u području vrlo visokih  tlakova. ]]></summary_hr><summary_en><![CDATA[Cobalt oxides of the perovskite type are attractive materials for photovoltaics, catalysts, thermoelectrics, batteries, supercapacitors, and storage devices. Their unique chemical, physical, and mechanical properties are due to the remarkable tunability of their crystal structure, which can be adjusted through chemical syntheses and/or high-pressure post-synthesis treatments. The synergy of knowledge on perovskite syntheses under ambient and non-ambient conditions will allow us to understand and develop the basis for the creation of new perovskite structures with unprecedented functional properties. In particular, the proposal aims to gain knowledge about the relationship between the synthesis pathways of cobaltite-based perovskites, (LaXCa1-XCoyM1-yO3-d (M = Ni, Co, Cr, Fe, x = 0.1-0.5; y = 0.1-1.0)  and their crystallographic and physicochemical features. To obtain different morphologies, sol-gel, co-precipitation, and mechanochemical chemistry will be used, while crystal structures and phase stabilities will be tuned by doping strategy. The course of conventional sintering and plasma deposition on thermally-induced transformations in the crystal structures and phases of the perovskites and their specific thermoelectric, electrocatalytic, and chemocatalytic functionalities will be studied in detail. In addition to chemical engineering, hydrostatic pressure will be used as a clean tool to tune the structures of selected perovskites and their functionalities, leading to exotic features like bandgap narrowing, photoluminescence intensity enhancement, ambient-memorised retainability, metallization, amorphization, and phase transitions. Selection of in situ high-pressure experiments (powder X-ray diffraction, Raman and absorption spectroscopy, and electrical resistance studies (up to 50 GPa) will improve the understanding of the underlying physics and structure-property correlations of prepared perovskites by revealing new features and functionalities.]]></summary_en></project><project>
<id>16506</id><title_hr><![CDATA[Od mora do vrha: održivo upravljanje osjetljivim krškim vodonosnicima pod klimatskim promjenama i antropogenim stresom]]></title_hr><title_en><![CDATA[From Sea to Summit: the sustainable management of fragile karst aquifers under changing climate and anthropogenic stress]]></title_en><user_id>6042</user_id><user_firstLast_name>Ivo Andrić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>WEAVE</proposal_type><proposal_call>2024</proposal_call><code>WEAVE-2024-1020</code><acronim><![CDATA[Sea2Summit]]></acronim><duration>01.12.2024 - 30.11.2028</duration><status>U tijeku</status><financ_value>198.550,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Građevinarstvo, </scie_field_hr><scie_field_en>Civil engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu Fakultet građevinarstva, arhitekture i geodezije]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Civil Engineering, Architecture and Geodesy]]></institution_en><team_members_id>17807, 872950, </team_members_id><team_members_names><![CDATA[Toni Kekez, Kajo Podrug, ]]></team_members_names><keywords_hr><![CDATA[Hidrogeologija, Hidrologija, Krš, Ledenjak, Otok, Vodoopskrba]]></keywords_hr><keywords_en><![CDATA[Hydrogeology, Hidrology,  Karst, Glacier, Island, Water Supply]]></keywords_en><summary_hr><![CDATA[Izvori pitke vode u planinskim područjima i na malim otocima iznimno su osjetljivi na učinke klimatskih promjena. Na prve utječe otapanje ledenjaka na velikim nadmorskim visinama, na druge podizanje razine mora i prodor slane vode u obalna područja. Dok su porozni vodonosnici sposobni odigrati važnu ulogu skladištenja i tampona, krške zone su mnogo reaktivnije i na njih ti čimbenici jače utječu. Krški slatkovodni resursi su visoko ugroženi klimatskim promjenama. Uz to, razvoj turizma dodatno povećava antropogeni pritisak na te resurse. Razumijevanje dinamike ovih sustava stoga je bitno za stanovništvo koje živi u tim sredinama.Projekt predlaže proučavanje dva mjesta koja detaljno prikazuju ove situacije. Prvi je otok Vis u Hrvatskoj, a drugo područje krški vodonosnik Tsanfleuron, koji opskrbljuje grad Conthey pitkom vodom. Za ove dvije regije, Sveučilište u Splitu i Sveučilište u Neuchâtelu predlažu udruživanje svoje komplementarne ekspertize kako bi se detaljno analiziralo stanje u ova dva slučaja, kako bi se predvidjeli mogući učinci klimatskih promjena prema različitim scenarijima koje je predstavio IPCC, te utvrditi kako ove prognoze treba pretočiti u mjere prilagodbe i ublažavanja utjecaja. Stoga je prvi cilj pokrenuti, nastaviti ili proširiti okvir praćenja obaju mjesta i karakterizirati te sustave s geološkog i hidrogeološkog stajališta te modeliranje opisanih procesa. Testiraju se različiti klimatski scenariji i strategije upravljanja u svrhu kreiranja operativnih politika koje vlasti mogu implementirati na ova dva mjesta. Osim specifičnog proučavanja ovih mjesta, primijenjene metode i rezultati promatranja trebali bi poslužiti kao osnova za rješavanje ove vrste problema za druga slična nalazišta diljem svijeta.]]></summary_hr><summary_en><![CDATA[Drinking water resources in mountain areas and on small islands are extremely sensitive to the effects of climate change. The former are affected by melting glaciers at high altitudes, the latter by rising sea levels, and saltwater intrusion in coastal areas. While porous or fractured aquifers are capable of playing an important storage and buffering role, karst zones are much more reactive, and are affected more violently by these factors. Karstic freshwater resources are highly threatened by climate change. In addition, the touristic development is adding further anthropogenic pressure on these resources. Understanding the dynamics of these systems is therefore essential for the populations living in these environments.The project proposes to study two sites that encapsulate these situations in detail. The first is the island of Vis in Croatia and the second site is the Tsanfleuron karstic aquifer, which supplies the town of Conthey with drinking water. For these two regions, the University of Split and the University of Neuchâtel propose to pool their complementary expertise to analyse the situation in detail in these two cases, to forecast the possible impacts of climate change according to the different scenarios presented by the IPCC, and identify how these forecasts should be translated into adaptation and impact mitigation measures. The first aim is therefore to launch, resume, or extend the monitoring framework of both sites and characterise these systems from a geological and hydrogeological standpoint and system modelling. Various climate scenarios and management strategies will be tested to eventually translate them into operational policies that the authorities can implement at these two sites. Beyond the specific study of these sites, the methods implemented and the results of the observations should serve as a basis for solving these types of problems for other similar sites around the world.]]></summary_en></project><project>
<id>16586</id><title_hr><![CDATA[Računalni vid u detekciji plodova i procjeni uroda maslina]]></title_hr><title_en><![CDATA[Computer vision in olive fruit detection and yield estimation]]></title_en><user_id>7703</user_id><user_firstLast_name>Vladan Papić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2024-05</proposal_call><code>IP-2024-05-6393</code><acronim><![CDATA[CoViO]]></acronim><duration>16.12.2024 - 15.12.2027</duration><status>U tijeku</status><financ_value>172.281,02 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, Elektrotehnika, </scie_field_hr><scie_field_en>Computer sciences, Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Fakultet elektrotehnike, strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Electrical Engineering, Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>7058, 23226, 26026, 13042, 867892, 865914, 866337, 866348, 20523, 2864, 873078, </team_members_id><team_members_names><![CDATA[Josip Musić, Mirjana Bonkovic, Stanko Kružić, Sven Gotovac, Toma Sikora, VASSILIS KABURLASOS, Mladenka Šarolić, Ivana Marin, Josip Gugić, Frane Strikić, Ana Šarić Gudelj, ]]></team_members_names><keywords_hr><![CDATA[maslinarstvo, računalni vid, duboke neuronske mreže, obrada slika, bespilotne letjelice]]></keywords_hr><keywords_en><![CDATA[olive growing, computer vision, deep neural networks, image processing, unmanned aerial vehicles]]></keywords_en><summary_hr><![CDATA[U okviru ovog projekta istraživanja će se fokusirati na uvođenje novih tehnologija i umjetne inteligencije u maslinarstvu. Prvi pravac istraživanja odnosi se na razvoj procedura i algoritama za analizu slika stabala masline a s ciljem detekcije plodova. Ovo je posebno izazovan zadatak jer se namjerava razviti postupak koji će omogućiti detekciju plodova i u ranim fazama razvoja kada su plodovi malih dimenzija. Drugi pravac istraživanja odnosi se na razvoj algoritama za procjenu zrelosti plodova te ukupnog uroda. Osnovna hipoteza je da se može razviti procedura koja će omogućiti da se iz snimki maslinika bespilotnom letjelicom dobije kvalitetna informacija o stanju plodova i procijeni urod. U ovom dijelu istražit će se i korelacija između intenziteta cvatnje sa konačnim rezultatima uroda. Tijekom istraživanja očekuje se formiranje referentne i javno dostupne baze označenih slika za učenje (različita doba dana i godine, različiti vremenski uvjeti). Postupci i algoritmi predobrade i obrade slika biti će prilagođeni za uspješan rad na slikama prikupljenim bespilotnom letjelicom te pod znatno manjim ograničenjima od pristupa do sada dostupnih u literaturi. Ispitat će se moguće poboljšanje kvalitete ulaznih podataka, a posljedično i rezultata kombiniranjem informacije dobivene s RGB i multispektralnog senzora. Osim toga, predložit će se i optimizirana arhitektura temeljena na dubokim neuronskim mrežama s ciljem izbjegavanja kompleksnosti i omogućavanja njene implementacije na manje zahtjevnim računalnim resursima.]]></summary_hr><summary_en><![CDATA[In this project, research w ill be focused towards introduction of new technologies and artificial intelligence in olive growing. First research direction is related to development of procedures and algorithms for olive trees analysis in order to detect olive fruits. This is especially challenging because intention is to develop a procedure that w ill enable detection of olive fruits in early stages of development w hen they are small. Second research direction is related to development of algorithms for estimation of fruit maturity and complete yield. Main hypothesis is that it is possible to develop a procedure that w ill enable quality information on fruits state and yield estimate based on olivegroves images taken with an unmanned aerial vehicle. In this part, correlation between flowering intensity and yield will be investigated. During research, forming of an reference and publicly available labeled images database is expected (various time of day and seasons, various weather conditions). Procedures and algorithms for image preprocessing will be adopted for successful implementation on images collected with a drone and also to work on less constrains then approaches presented in the literature. Investigation of possible quality improvement of input data and, consequently, also the final results based on combination of information obtained RGB and multispectral sensors. Moreover, optimized architecture based on deep neural networks will be proposed in order to lower complexity and allow implementation on less demanding hardware.]]></summary_en></project><project>
<id>16591</id><title_hr><![CDATA[Raščlamba zalihosti izoformi proteina Rac1 u protistu Dictyostelium discoideum]]></title_hr><title_en><![CDATA[Dissecting the redundancy of Rac1 isoforms in Dictyostelium discoideum]]></title_en><user_id>7715</user_id><user_firstLast_name>Igor Weber</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2024-05</proposal_call><code>IP-2024-05-6331</code><acronim><![CDATA[DiRac]]></acronim><duration>16.12.2024 - 15.12.2027</duration><status>U tijeku</status><financ_value>186.475,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, Interdisciplinarne prirodne znanosti, </scie_field_hr><scie_field_en>Biology, Interdisciplinary natural sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>12535, 865524, 12533, 873327, 873116, </team_members_id><team_members_names><![CDATA[Vedrana Filić Mileta, Darija Putar Brajković, Marko Šoštar, Sara Cerovski, Marija Šimić, ]]></team_members_names><keywords_hr><![CDATA[stanično kretanje, Rho GTPaze, aktinski citoskelet, Dictyostelium, teorijsko modeliranje]]></keywords_hr><keywords_en><![CDATA[cell motility, Rho GTPases, actin cytoskeleton, Dictyostelium, theoretical modelling]]></keywords_en><summary_hr><![CDATA[Male GTPaze iz obitelji Rho dobro su poznate kao glavni regulatori aktinskog citoskeleta. Članovi potporodice Rac prvenstveno su uključeni u regulaciju stanične pokretljivosti, invazivnosti i adhezije, a njihova deregulacija povezana je s patogenezom brojnih bolesti. GTPaze iz grupe Rac primarno potiču stvaranje staničnih izbočina koje stvara aktin, ali izvješća o učincima nedostatka proteina Rac u različitim staničnim linijama nisu dosljedna. Poput sisavaca, amebe Dictyostelium izražavaju tri osnovne izoforme proteina Rac, ali pitanje njihove funkcionalne redundancije nije razjašnjeno. Ovo ćemo pitanje razmotriti provođenjem sveobuhvatne fenotipske karakterizacije nedavno kreiranih mutiranih stanica koje eksprimiraju parove ili samo pojedinačne izoforme Rac1. Usredotočit ćemo se na procese koji uključuju aktinski citoskelet, kao što su stanični rast, fagocitoza, makropinocitoza, migracija, adhezija, kemotaksija, citokineza i višestanični razvoj. Također ćemo proučavati ponašanje stanica kojima nedostaju izoforme Rac1 u trodimenzionalnim matricama, pod kompresijom, u struji tekućine i na ljepljivim površinama. Prekid signalnih putova koji vode do uočenih fenotipova istražit će se studijama lokalizacije i interakcija efektora GTPaza Rac1 u mutiranim stanicama. Aktivnost preostalih izoformi Rac1 u dvostrukim mutantima istražit će se praćenjem lokalizacije fluorescentne sonde specifične za Rac1-GTP. Nedavno smo otkrili da aktivnost proteina Rac1 u stanicama Dictyostelium može pokazivati oscilatornu dinamiku. Razvit ćemo elementarni deterministički i stohastički reakcijsko-difuzijski model dinamike Rac1 s očuvanjem mase koji će uključiti samo aktivaciju, deaktivaciju i difuziju. Usporedba između opažene i simulirane dinamike pojedinačnih izoformi Rac1 omogućit će nam da donesemo zaključke o specifičnim regulatornim mehanizmima koji kontroliraju vezanje proteina Rac1 na membranu i njegovo otpuštanje s membrane, te njihovu spregu s ciklusom aktivacije i deaktivacije.]]></summary_hr><summary_en><![CDATA[Small GTPases of the Rho family are well known as master regulators of the actin cytoskeleton. Members of the Rac subfamily are primarily involved in the regulation of cell motility, invasiveness and adhesion, and their dysregulation is associated with the pathogenesis of numerous diseases. Rac GTPases primarily promote the formation of actin-driven cell protrusions, but reports on the effects of Rac deficiency in different cell lineages are inconsistent. Similar to mammals, Dictyostelium amoebae express three basic Rac isoforms, but the question of their functional redundancy remains unresolved. We will address this question by performing a comprehensive phenotypic characterization of newly generated mutant cells expressing pairs or only single Rac1 isoforms. We will focus on processes involving the actin cytoskeleton, such as cell growth, phagocytosis, macropinocytosis, migration, adhesion, chemotaxis, cytokinesis and multicellular development. We will also study the behavior of Rac1-deficient cells in three-dimensional matrices, under compression, against flow and on adhesive surfaces. The disruption of signaling pathways leading to the observed phenotypes will be investigated by localization and interaction studies with Rac1 effectors in mutant cells. The activity of the remaining Rac1 isoforms in double mutants will be investigated by monitoring localization of a fluorescent probe specific for Rac1-GTP. We have recently discovered that Rac1 activity in Dictyostelium cells can exhibit oscillatory dynamics. We will develop elementary mass-conserving deterministic and stochastic reaction-diffusion models of Rac1 dynamics that include only activation, deactivation and diffusion. The comparison between the observed and simulated dynamics of single Rac1 isoforms will alow us to draw conclusions about specific regulatory mechanisms that control the recruitment of Rac1 to, and the release from, the membrane, and their coupling with the activation/deactivation cycle.]]></summary_en></project><project>
<id>16598</id><title_hr><![CDATA[ Formalni sistemi i modeliranje]]></title_hr><title_en><![CDATA[ Formal systems and modeling ]]></title_en><user_id>21409</user_id><user_firstLast_name>Tin Perkov</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2024-05</proposal_call><code>IP-2024-05-3882</code><acronim><![CDATA[ FORMALS-2]]></acronim><duration>09.12.2024 - 08.12.2027</duration><status>U tijeku</status><financ_value>81.765,00 eur</financ_value><scie_area_hr>Prirodne znanosti, Društvene znanosti, Humanističke znanosti, </scie_area_hr><scie_area_en>Natural sciences, Social sciences, Humanities, </scie_area_en><scie_field_hr>Matematika, Informacijske znanosti, Filologija, Kognitivna znanost, </scie_field_hr><scie_field_en>Mathematics, Information sciences, Philology, Cognitive science, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Učiteljski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Teacher Education]]></institution_en><team_members_id>7485, 3707, 12963, 12516, 21430, 25905, 22496, 858383, 865425, 865424, 1312, 4388, 23804, 23844, 867927, 23890, </team_members_id><team_members_names><![CDATA[Zvonimir Šikić, Predrag Vuković, Tajana Ban Kirigin, Marcel Maretić, Luka Mikec, Mandi Orlić Bachler, Aleksandar Hatzivelkos, Tin Adlešić, Stipe Marić, Teo Šestak, Sanda Bujačić Babić, Benedikt Perak, Mladen Vuković, Marko Horvat, Helena Marciuš, Sebastijan Horvat, ]]></team_members_names><keywords_hr><![CDATA[matematička logika, modalna logika, teorija modela, logika u računarstvu, formalno rasuđivanje]]></keywords_hr><keywords_en><![CDATA[mathematical logic, modal logic, model theory, logic in computer science, formal reasoning]]></keywords_en><summary_hr><![CDATA[Projekt će koordinirati rad istraživačke grupe u području matematičke logike i primjena, formirane prethodnim projektom (HRZZ-UIP-2017-05-9219), u kojoj je uspostavljena suradnja istraživača iz teorijske i primijenjene logike. U fokusu projekta su primjene logike u računarstvu i obratno, primjene računalnih alata u logičkom i matematičkom istraživanju, te primjene logike u problemima drugih disciplina (lingvistika, kognitivne i informacijske znanosti, teorija društvenog izbora). Osobito su važni sistemi modalne logike, koji se primjenjuju u iznenađujuće raznolikim područjima na sličan način. Matematičko modeliranje i logička formalizacija problema donosi pojmovnu preciznost, sigurnost u dokazivanju novih spoznaja i mogućnost rasvjetljavanja problema koji u neformalnom rasuđivanju često ostaju skriveni. Članovi istraživačke grupe su iz područja matematike, informacijskih znanosti i lingvistike. Teme prijedloga uključuju 1) modalnu logiku, 2) logičke i računalne aspekte teorije društvenog izbora, 3) primjene u cyber-physical sistemima i kognitivno-lingivističkoj analizi, te 4) fundamentalne i interdisciplinarne teme u logici i matematici. Ciljevi uključuju 1) potpunost, odlučivost i složenost sistema modalne logike, veze između različitih semantika logike interpretabilnosti 2) aksiomatizaciju i formalizaciju pojma kompromisa, 3) razvoj metoda i alata za identifikaciju svojstava jezičnih struktura, 4) generalizaciju modalnih semantika sredstvima kategorijske logike i teorije toposa. Metode istraživanja su matematičko modeliranje i logička formalizacija danih problema, deduktivno istraživanje dobivenih formalizacija i povratna primjena na polazni problem. Pritom će se, tamo gdje je prikladno, razvijati i implementirati odgovarajući algoritmi. Mjerljivi rezultati projekta bit će prije svega znanstveni članci objavljeni u relevantnim međunarodnim časopisima, kao i prezentacija ostvarenih rezultata na kompetitivnim međunarodnim konferencijama.]]></summary_hr><summary_en><![CDATA[Project will coordinate the work of research group in mathematical logic and applications, formed through the previous project (HRZZ-UIP-2017-05-9219), in which collaboration was established between researchers in pure and applied logic. Focus of the proposal are applications of logic in computer science and vice versa, applications of computational tools in logical and mathematical research, and applications of logic to problems of other fields (linguistics, cognitive and information sciences, social choice theory). Modal logic systems are of particular interest, since they are applied in surprisingly different areas in similar way. Modeling and formalization of problems brings conceptual clarity, confidence in proving new results and enlightens issues which often remain hidden in informal reasoning. Research group members have background in mathematics, information sciences and linguistics. Proposal topics include 1) modal logic, 2) logical and computational aspects of social choice theory 3) applications to cyber-physical systems and cognitive-linguistic analysis, 4) fundamental and interdisciplinary topics in logic and mathematics. Objectives include 1) completeness, decidability and complexity of modal logic systems, relations between different semantics of interpretability logic, 2) axiomatization and formalization of the notion of compromise, 3) developing methods and tools for identification of properties of language structures 4) generalization of modal semantics by means of categorial logic and topos theory. The methodology is mathematical modeling and logical formalization of given problems, deductive research of the obtained formalization and application of its results to the starting problem. When appropriate, algorithms to solve given problems will be developed and implemented. Measurable results of the projects will be research papers published in relevant international journals and presented at competitive international conferences.]]></summary_en></project><project>
<id>16602</id><title_hr><![CDATA[Neuroprotektivno djelovanje florotanina iz makroalgi Jadranskog mora u zebrici Danio rerio kao modelu Parkinsonove bolesti]]></title_hr><title_en><![CDATA[Neuroprotective potential of phlorotannins from the Adriatic Sea macroalgae on a zebrafish Danio rerio model of Parkinson&#39;s disease]]></title_en><user_id>13019</user_id><user_firstLast_name>Sanja Babić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2024-05</proposal_call><code>IP-2024-05-2216</code><acronim><![CDATA[NeuroFishAdria]]></acronim><duration>20.12.2024 - 19.12.2027</duration><status>U tijeku</status><financ_value>199.905,50 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, Interdisciplinarne prirodne znanosti, </scie_field_hr><scie_field_en>Biology, Interdisciplinary natural sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>868141, 3091, 5798, 12826, 4351, 865092, 868190, 20232, 858339, 873024, </team_members_id><team_members_names><![CDATA[Ana Cristina Rego, Aleksandra  Maršavelski, Ivančica Strunjak-Perović, Rozelindra Čož-Rakovac, Petar Kružić, Tina Miloš, Mojca Bavcon Kralj, Sanja Radman, Barbara Vuić, Matea Matković, ]]></team_members_names><keywords_hr><![CDATA[smeđe makroalge, florotanini, bioaktivnost, Danio rerio, Parkinsonova bolest, biotestovi]]></keywords_hr><keywords_en><![CDATA[brown macroalgae, phlorotannins, bioactivity, Danio rerio, Parkinson&#39;s disease, bioassays]]></keywords_en><summary_hr><![CDATA[Više od 10 milijuna ljudi diljem svijeta boluje od Parkinsonove bolesti (PB), progresivnog neurodegenerativnog poremećaja karakteriziranog brojnim motoričkim i nemotoričkim simptomima. Trenutna terapija je simptomatska i često je popraćena sa značajnim nuspojavama. Unatoč brojnim pokušajima, još uvijek nije pronađen spoj/lijek koji može promijeniti tijek bolesti. Florotanini, polifenolni spojevi koji se nalaze u smeđim makroalgama, prepoznati su kao izvrsni kandidati za razvoj terapeutika nove generacije. Međutim, njihovo neuroprotektivno djelovanje još uvijek je nedovoljno istraženo. Cilj ovog projekta je ispitati neuroprotektivan potencijal florotanina iz smeđih makroalgi Jadranskog mora. Naš multidisciplinarni pristup kombinira in silico, in vitro i in vivo metodologije kako bi razjasnili mehanizam djelovanja florotanina u vidu zaštite neuralnih tkiva i potencijalnog ublažavanja/izlječenja PB-i. Korištenjem ličinaka i odraslih zebrica Danio rerio, moći ćemo sveobuhvatno ispitati napredovanje bolesti i simptoma povezanih s patologijom PB-i u različitim životnim fazama. Ovakav pristup omogućit će nam procjenu zaštitnih učinaka florotanina protiv motoričkih deficita, kao i biokemijskih i molekularnih promjena u mozgu zebrice karakterističnih za PB. Nadalje, pristup korišten unutar ovog projekta mogao bi predstavljati platformu za probir velikog broja prirodnih spojeva sa zaštitnim učinkom protiv PB-i i tako ubrzati otkriće i razvoj novih lijekova u budućnosti. Stvaranjem baze florotanina s neuroprotektivnim djelovanjem prisutnih u makroalgama Jadranskog mora, ovaj projekt otvorit će mogućnost suradnje s farmaceutskom industrijom i ubrzati razvoj terapeutika na bazi algi. Dobiveni rezultati mogli bi imati znanstvene i društvene implikacije, kako podizanjem osviještenosti o bolesti, tako i smanjenjem ekonomskih i zdravstvenih izdataka povezanih s PB-i.]]></summary_hr><summary_en><![CDATA[Over 10 million people worldwide suffer from Parkinson&#39;s disease (PD), a progressive neurodegenerative disorder characterized by motor and non-motor symptoms. Current treatments are primarily symptomatic and often come with significant side effects. To date, no therapy has been found that can halt or reverse the progression of PD. In this context, phlorotannins, polyphenols produced by brown macroalgae, have emerged as promising candidates for developing new-generation therapeutics. However, research on their neuroprotective effects is still in its infancy. This project investigates the neuroprotective effects of phlorotannins derived from brown macroalgae of the Adriatic Sea. Our multidisciplinary approach combines in silico, in vitro, and in vivo methodologies to elucidate the mechanism through which these compounds may protect neural tissues and potentially mitigate PD. By utilizing both larval and adult zebrafish Danio rerio we will be able to thoroughly examine PD&#39;s progression and pathology-related symptoms across different life stages. This comprehensive strategy will enable us to assess the protective effects of phlorotannins against motor deficits, as well as biochemical and molecular alterations in the PD-induced zebrafish model, providing valuable insights into potential treatments for neurodegenerative disorders. Additionally, such an approach will provide a screening platform for determining the anti-PD effect of myriad biomolecules, thus accelerating the discovery and development of algae-based therapeutics. By creating a library of phlorotannins with neuroprotective effects from the Adriatic Sea macroalgae, this project aims to foster collaborations with the pharmacological industry, potentially leading to breakthrough treatments for neurodegenerative diseases. The implications of our findings could significantly alleviate the societal and economic/healthcare burdens associated with PD by advancing understanding and treatment options.]]></summary_en></project><project>
<id>16614</id><title_hr><![CDATA[Interactions in the Coccolithophore Phycosphere and Implications for Ocean Carbon Cycling]]></title_hr><title_en><![CDATA[Interakcije u fikosferi kokolitoforida i implikacije za kruženje ugljika u oceanu]]></title_en><user_id>451</user_id><user_firstLast_name>Jelena Godrijan</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2024-05</proposal_call><code>IP-2024-05-3942</code><acronim><![CDATA[Cocco-Channel]]></acronim><duration>20.12.2024 - 19.12.2027</duration><status>U tijeku</status><financ_value>199.999,38 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Interdisciplinarne prirodne znanosti, Biologija, </scie_field_hr><scie_field_en>Interdisciplinary natural sciences, Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>2776, 868240, 868280, 6043, 868501, 873022, </team_members_id><team_members_names><![CDATA[Tanja Vojvoda Zeljko, Frederic Chaux-Jukic, Borna Branimir Vuković, Jelena Mandić, Tinkara Tinta, Lucija Berlančić, ]]></team_members_names><keywords_hr><![CDATA[morska mikrobiologija, ekologija fitoplanktona, co-culturing, okolišna biologija, kemijska oceanografija, ]]></keywords_hr><keywords_en><![CDATA[marine microbiology, phytoplankton ecology, co-culturing, environmental biology, chemical oceanography]]></keywords_en><summary_hr><![CDATA[Ocean je danas daleko najveći rezervoar ugljika i važan je ponor ugljika. Jedan od ključnih igrača u njegovoj sposobnosti snižavanja atmosferskog CO2 su kokolitoforidi. One su jednostanične morske alge koje pridonose globalnom ciklusu ugljika ne samo fotosintezom već i kalcifikacijom i njihove su stanice prekrivene kalcitnim pločama. Međutim, oni ne djeluju sami. Mikrookoliš koji ih okružuje bogat je hranjivim tvarima izvanstanične organske tvari i utočište bogate mikrobne zajednice. Ovo okruženje poznato je kao fikosfera, a interakcije mikroba unutar njega kreću se od pozitivnih do antagonističkih. Takvi odnosi značajno utječu na cjelokupnu dinamiku ekosustava, na primjer potičući ili prekidajući širenje velikih cvjetanja kokolitoforida. No, u tom mikrookruženju ima još puno nepoznanica. Projekt Cocco-Channel ima za cilj proučavanje interakcija između kokolitoforida i njihovih povezanih bakterijskih zajednica unutar fikosfere i razumijevanje kako ti odnosi utječu na sposobnost oceana da hvata CO2. Ovo istraživanje ima za cilj otkriti zamršenu dinamiku ovih interakcija na mikro razini integracijom metoda iz mikrobne biologije, genomike, oceanografije i kemije ugljika. Istražujući razmjenu i strukturu mikrobnih zajednica povezanih s različitim vrstama kokolitoforida, projekt ima za cilj pružiti dublji uvid u utjecaj tih mikroorganizama na oceanski ciklus ugljika. Uz laboratorijske pokuse i pokuse u mikrokozmosu, naše terenske studije analizirat će sastav, funkcije i dinamiku interakcije prirodnih zajednica kokolitoforida i njima pridružene mikrobiote. Ovaj sveobuhvatni pristup pomoći će kvantificirati utjecaj kokolitoforida na sekvestraciju ugljika i pružiti važne podatke za usavršavanje klimatskih modela i razvoj strategija za ublažavanje učinaka klimatskih promjena.]]></summary_hr><summary_en><![CDATA[The ocean is by far the largest carbon reservoir today and is an important carbon sink. One of the key players in its capacity to draw down atmospheric CO2 are coccolithophores. They are unicellular marine algae that contribute to this global carbon cycle not only through photosynthesis but also through calcification, as their cells are covered by calcite plates. However, they are not acting alone. The microenvironment that surrounds them is rich in nutrient dense extracellular organic matter and harbours a rich microbial community. This environment is known as the phycosphere, and the microbial interactions within it range from mutualistic to antagonistic. Such relationships significantly influence the overall dynamics of the ecosystem, for example by promoting or terminating the spread of large coccolithophore blooms. However, there are still many unknowns in this microenvironment. The Cocco Channel project aims to study the interactions between coccolithophores and their associated bacterial communities within the phycosphere and to understand how these relationships influence the ocean&#39;s ability to capture CO2. This research aims to uncover the intricate dynamics of these microscale interactions by integrating methods from microbial biology, genomics, oceanography and carbon chemistry. By exploring the exchange and the structure of microbial communities associated with different coccolithophore species, the project aims to provide deeper insights into the impact of these microorganisms on the oceanic carbon cycle. In addition to laboratory and microcosm experiments, our field studies will analyse the composition, functions and interaction dynamics of natural coccolithophore communities and their associated microbiota. This comprehensive approach will help to quantify the impact of coccolithophores on carbon sequestration and provide important data for the refinement of climate models and the development of strategies to mitigate the effects of climate change.]]></summary_en></project><project>
<id>16619</id><title_hr><![CDATA[Sklerokronologija školjkaša – saznanja iz prošlosti o ekologiji i okolišu za buduće zdravlje obalnih ekosustava]]></title_hr><title_en><![CDATA[Bivalve Sclerochronology - lessons from Past Ecology and Environments for the future Coastal ecosystem Health]]></title_en><user_id>667</user_id><user_firstLast_name>Melita Peharda Uljević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2024-05</proposal_call><code>IP-2024-05-2190</code><acronim><![CDATA[BivalveSPEECH]]></acronim><duration>10.12.2024 - 09.12.2027</duration><status>U tijeku</status><financ_value>127.799,50 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, Geologija, Geofizika, Interdisciplinarne prirodne znanosti, </scie_field_hr><scie_field_en>Biology, Geology, Geophysics, Interdisciplinary natural sciences, </scie_field_en><institution_hr><![CDATA[Institut za oceanografiju i ribarstvo]]></institution_hr><institution_en><![CDATA[Institute of Oceanography and Fisheries]]></institution_en><team_members_id>25078, 25204, 3525, 670, 868401, 5837, 499, 12898, 25807, 867756, 867816, 357, 27884, 21180, </team_members_id><team_members_names><![CDATA[Hana Uvanović, Petra Zemunik, Hrvoje Mihanović, Daria Ezgeta Balić, Niko Bujas, Ivan Župan, Dario Vujević, Mario Bodružić, Bernd R. Schoene, Niels de Winter, Meghan Burchell, Ivica Janeković, Elizabeth M.  Harper, Antonela Barbir, ]]></team_members_names><keywords_hr><![CDATA[Školjkaši, ekologija mora, sklerokronologija, paleooceanografija, arheologija, akvakultura]]></keywords_hr><keywords_en><![CDATA[bivalves, marine ecology, sclerochronology, paleooceanography, archaeology, aquaculture ]]></keywords_en><summary_hr><![CDATA[Projekt BivalveSPEECH koristi ljušture školjkaša za dokumentiranje promjena u varijabilnosti morske klime primjenom sklerokronološkog pristupa. Kombinira promatranje okoliša i modeliranje s analizom obrazaca rasta školjkaša i geokemije njihovih ljuštura, duž proširene vremenske skale, od neolitika do daleke budućnosti. Glavne ciljne vrste su gospodarski važni školjkaši - sredozemna dagnja (Mytilus galloprovincialis) i europska kamenica (Ostrea edulis), a uzorkovanje će se provoditi na arheološkim nalazištima i uzgajalištima školjkaša duž istočnog Jadrana. Obrasci rasta ljuske analizirat će se iz acetatnih replika presjeka ljuštura i varijacija u mikrostrukturi ljuštura, dok će se stabilni izotopi kisika (d18O), ugljika (d13C) i dušika (d15N) analizirati u karbonatnom materijalu. Dobiveni podaci o školjkašima bit će povezani s podacima o kemiji vode, promatranim i modeliranim vrijednostima temperature i saliniteta sa visokom vremenskom rezolucijom, te klimatskim projekcijama. Projekt BivalveSPEECH rezultirat će snažnom rekonstrukcijom prošlih uvjeta okoliša i varijacijama u sezonalnosti rasta školjkaša. Doprinijet će našem razumijevanju dugoročnih promjena u morskim ekosustavima i njihovom zdravlju te će pružiti važne podatke za održivo upravljanje akvakulturom školjkaša u obalnim područjima u sadašnjim i budućim klimatskim uvjetima.]]></summary_hr><summary_en><![CDATA[The BivalveSPEECH project uses bivalve shells to document changes in marine climate variability by applying a sclerochronological approach. It combines environmental observations and modelling with analysis of shell growth patterns and shell geochemistry along an extended time scale, from the Neolithic to the far future. The main target species are commercially important bivalves - the Mediterranean mussel (Mytilus galloprovincialis) and the European flat oyster (Ostrea edulis) and sampling will be conducted at archaeological sites and bivalve aquaculture farms along the eastern Adriatic Sea. Shell growth patterns will be analysed from acetate peel replicas of shell cross sections and variations in shell microstructures, while oxygen (d18O), carbon (d13C), and nitrogen stable isotopes (d15N) will be analysed in shell carbonate material. Obtained shell data will be related to water chemistry data, high-resolution temperature and salinity environmental observations and modelling, and climate projections. The BivalveSPEECH project will result in a robust reconstruction of past environmental conditions and variations in bivalve growth seasonality. It will contribute to our understanding of long-term changes in marine ecosystems and their health and will provide important data for sustainable management of bivalve aquaculture in coastal areas in present and future climate conditions.]]></summary_en></project><project>
<id>16625</id><title_hr><![CDATA[Strojno Učenje i Kvantni Algoritmi za Fiziku Visokih Energija]]></title_hr><title_en><![CDATA[Machine Learning and Quantum Algorithms for High Energy Physics]]></title_en><user_id>865883</user_id><user_firstLast_name>Pedrame Bargassa</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2024-05</proposal_call><code>IP-2024-05-3767</code><acronim><![CDATA[MLQA4HEP]]></acronim><duration>19.12.2024 - 18.12.2027</duration><status>U tijeku</status><financ_value>156.250,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>11164, 872788, </team_members_id><team_members_names><![CDATA[Vuko Brigljević, Sacha Cormenier, ]]></team_members_names><keywords_hr><![CDATA[Strojno učenje, kvantno računalstvo, kvantni algoritam, fizika čestica, prepoznavanje uzoraka, detektori nabijenih tragova]]></keywords_hr><keywords_en><![CDATA[Machine Learning, Quantum Computing, Quantum Algorithm, Particle physics, Pattern recognition, Tracking detectors]]></keywords_en><summary_hr><![CDATA[Ovaj prijedlog nalazi se na mostu između kvantnog računarstva (QC) i algoritama (QA) i strojnog učenja (ML, od engl. Machine Learning) s jedne strane i fizike čestica s druge strane. Cilj mu je primjena i razvoj QC/QA i ML za goleme izazove fizike čestica na Velikom hadronskom sudarivaču (LHC), kako za klasifikaciju događaja tako i za rekonstrukciju čestica iz signala detektora. Za klasifikaciju, referentni signal koji se želi odvajati od pozadinskih procesa je supersimetrični top kvark (stop), fenomenološki dobro motivirana čestica, koja se aktivno traži na LHC-u. Prijedlog se nadovezuje i nadilazi ranije objavljene rezultate voditelja projekta, koji su uveli korištenje klasičnih i kvantnih ML alata u potrazi za stop česticom. Napredna neuronska mreža bit će podešena kao klasični ML, dok će se kvantni potporni vektorski stroj i kvantni varijacijski klasifikator koristiti kao kvantni ML. Za rekonstrukciju, cilj nam je odgovoriti na izazove faze visokog luminoziteta (HL) LHC-a, gdje će jako veliki broj istovremeno proizvedenih nabijenih čestica u detektoru predstavljati veliki računalni izazov, dakle za rekonstrukciju događaja: rekonstrukcija tragova čestica je, s postojećim algoritmima, toliko spora da se neće moći nositi s brojem istovremenih proton proton sudara koji se očekuju u uvjetima HL-LHC, njih preko 200. Stoga je cilj razviti algoritme temeljene na QA/QC koji su brži od klasičnih, a da zadrže svoju učinkovitost za rekonstrukciju tragova čestica. Izazov rekonstrukcije putanja čestica na HL- LHC-u je toliko golem da će sigurno doprinijeti razvoju QA/QC poljia. Planiramo istražiti primjenu kvantnih algoritama kao što su kvantno žarenje i kvantni hod na izazovni problem prepoznavanja uzoraka u detektorima za mjerenje tragova nabijenih čestica. Očekuje se da će manja složenost takvih algoritama rezultirati manjim CPU vremenom potrebnim za rekonstrukciju putanja čestica.]]></summary_hr><summary_en><![CDATA[This proposal is at the interface of Quantum-Computing (QC) and Algorithms (QA) and Machine Learning (ML) on one hand, and particle physics on the other. It aims at applying and developing QC/QA and ML to the tremendous challenges of particle physics at the Large Hadron Collider (LHC), both for event classification & reconstruction of particles from detector signals.For classification, the benchmark signal to separate from background processes is the supersymmetric top quark (stop), a phenomenologically well motivated particle, which is actively searched at the LHC. The proposal builds on and goes beyond earlier published results by the PI, which introduced the usage of both classical and quantum based ML tools in the stop search.An advanced neural-network will be tuned as classical ML, while quantum support vector machine and quantum variational classifier willbe used as quantum ML.For reconstruction, we aim to meet the challenges of the High-Luminosity (HL) phase of the LHC, where the very high number of produced charged particles represent a huge challenge for computation, thus for event reconstruction: the time for reconstructing tracks of charged particles is, with present algorithms, so slow that it could not cope with the number of pile-up events at the HL-LHC, which is expected to be around 200. Therefore, the goal is to build QA/QC based algorithms which are faster than classical ones, while maintaining their efficiency for reconstructing tracks. The challenge of track reconstruction at the HL-LHC is so immense that it will certainly help the QA/QC fields to grow.We plan to explore the application of quantum algorithms such as quantum annealing, and quantum walk to the challenging problem of pattern recognition in tracking detectors. The lower complexity of such algorithms is expected to result in a lower CPU time needed for track reconstruction.]]></summary_en></project><project>
<id>16627</id><title_hr><![CDATA[Proširivanje sintetskog opsega halogenhidrin dehalogenaza]]></title_hr><title_en><![CDATA[Expanding the synthetic scope of halohydrin dehalogenases]]></title_en><user_id>3232</user_id><user_firstLast_name>Irena Dokli</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2024-05</proposal_call><code>IP-2024-05-1376</code><acronim><![CDATA[SynthScope]]></acronim><duration>09.12.2024 - 08.12.2027</duration><status>U tijeku</status><financ_value>199.720,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>858379, 3241, 19060, 22528, 873187, </team_members_id><team_members_names><![CDATA[Petra Švaco, Anamarija Knežević, Maja Majerić Elenkov, Danijel Glavač, Doroteja Mutak, ]]></team_members_names><keywords_hr><![CDATA[enzimi, biokataliza, kinetička rezolucija, asimetrična sinteza, halogenhidrin dehalogenaze]]></keywords_hr><keywords_en><![CDATA[enzymes, biocatalysis, kinetic resolution, asymmetric synthesis, halohydrin dehalogenases, propargyl epoxides]]></keywords_en><summary_hr><![CDATA[Asimetrična sinteza, metoda u organskoj kemiji za pripremu kiralnih molekula, oslanja se između ostalih i na tehnike poput biokatalize, koristeći enzime kako bi se osigurala visoka selektivnost reakcije. Halogenhidrin dehalogenaze (HHDH) privukle su pozornost zbog dobrih biokatalitičkih svojstava, otvarajući razne sintetske mogućnosti. Unatoč ograničenjima kao što su loša topljivost i mala dozvoljena koncentracija supstrata te razne inhibicije samog enzima, HHDH se mogu koristiti za različite kemoenzimatske sinteze. Unutar ovog projekta nastojati će se proširiti opseg supstrata HHDH na propargilne i homopropargilne epokside s ciljem dobivanja vrijednih kiralnih alkohola s raznolikom reaktivnošću. Propargilni i homopropargilni epoksidi te alkoholi mogu reagirati različitim inter- i intramolekularnim reakcijama zbog prisutnosti trostruke veze. Ove reakcije vode do različitih heterocikličkih spojeva, kao što su furani, piroli, triazoli i aleni. Takva svestranost čini propargilne spojeve vrlo poželjnim intermedijerima u sintezi organskih spojeva, uključujući biološki aktivne tvari, prirodne spojeve i lijekove. Unatoč njihovom značaju, stereoselektivna priprema propargilnih i homopropargilnih epoksida i alkohola ostaje izazov u organskoj sintezi. Koristeći enzimsku rezoluciju kao ekološki prihvatljivu i pristupačnu metodu, ovaj projekt ima za cilj otključati sintetski potencijal propargilnih spojeva, utirući put za učinkovitu pripremu vrijednih kiralnih gradivnih blokova.]]></summary_hr><summary_en><![CDATA[Asymmetric synthesis, crucial in organic chemistry for producing single enantiomers, relies on techniques like biocatalysis, utilizing enzymes to ensure high selectivity. Halohydrin dehalogenases (HHDHs) have gained attention for their biocatalytic prowess, opening up various synthetic possibilities. Despite limitations like low substrate solubility, low substrate concentration, and possible enzyme inhibitions, HHDHs offer promise for diverse chemoenzymatic syntheses. Within this project we aim to expand the substrate scope of HHDHs to propargylic and homopropargylic epoxides aiming to obtain valuable chiral alcohols with versatile reactivity. Propargylic and homopropargylic epoxides and alcohols, can undergo various inter- and intramolecular reactions due to the presence of the triple bond. These reactions can lead to the formation of diverse heterocyclic compounds, such as furans, pyrroles, triazoles, and allenic compounds. Such versatility makes propargylic compounds highly desirable as intermediates in the synthesis of organic compounds, including biologically active substances, natural products, and pharmaceuticals. Despite their significance, the stereoselective preparation of propargylic and homopropargylic epoxides and alcohols remains a challenge in organic synthesis. By exploring enzymatic resolution as an environmentally friendly and accessible alternative method, this project aims to unlock the synthetic potential of propargylic compounds, paving the way for the efficient production of valuable chiral building blocks.]]></summary_en></project><project>
<id>16634</id><title_hr><![CDATA[Neperturbativni QCD u fizici teških okusa]]></title_hr><title_en><![CDATA[Nonperturbative QCD in heavy flavour physics]]></title_en><user_id>2665</user_id><user_firstLast_name>Blaženka Melić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2024-05</proposal_call><code>IP-2024-05-4427</code><acronim><![CDATA[BeDeM]]></acronim><duration>20.12.2024 - 19.12.2027</duration><status>U tijeku</status><financ_value>162.690,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>866160, 866657, 867893, 873224, </team_members_id><team_members_names><![CDATA[Ivan Nisandzic, Lovro Dulibić, Alexey Petrov, MohdSiddiqueAkbarAlam Khan, ]]></team_members_names><keywords_hr><![CDATA[fizika teških okusa, neperturbativni QCD, funkcije strukture, CKM matrica miješanja okusa, oscilacije i rijetki raspadi D-mezona]]></keywords_hr><keywords_en><![CDATA[heavy flavour physics, nonperturbative QCD, form factors, CKM mixing matrix, D-meson oscillations and rare decays]]></keywords_en><summary_hr><![CDATA[Postizanje potrebne preciznosti za potpuno razumijevanje fizike teških okusa zahtijeva razumijevanje neperturbativne QCD (kvantne kromodinamike) u raspadima teških mezona. Stoga se u ovom projektu bavimo neperturbativnim svojstvima QCD-a u određenim raspadima teških mezona, provodeći istraživanje u dva glavna smjera. Prvo, istražujemo neperturbativne učinke QCD-a koristeći metodu nelokalnih kondenzata, u procesima koji su posebno osjetljivi na temeljnu neperturbativnu dinamiku - u miješanju neutralnih D0-mezona, te u rijetkim D-mezonskim raspadima. Cilj nam je objašnjenje značajne diskrepancije između izmjerenih parametara miješanja D0-mezona i njihovih perturbativnih predviđanja koja sugeriraju četiri redova veličine manje rezultate. Također ćemo precizno odrediti neperturbativne učinke QCD-a u rijetkim D-raspadima koji su osjetljivi na neperturbativnu dinamiku, pružajući tako predviđanja za sadašnje i buduće sudarače. Drugo, naše istraživanje usmjereno je na razumijevanje neperturbativne dinamike u odabranim raspadima B- i D-mezona u lake mezone s ciljem prekomjernog ograničavanja elementa Vub (i Vcd) CKM matrice. To ćemo postići preciznim određivanjem funkcija strukture koristeći metodu sumacijskih pravila na svjetlosnom stošcu. Dodatno, istraživanje poluleptonskih B(s), D(s) -> eta,eta&#39; raspada nam omogućuje ne samo određivanje preciznih omjera grananja za te raspade i ekstrakciju CKM elemenata, već i ekstrakciju kuta miješanja eta-eta’ mezona. Spajanjem dobivenih funkcija strukture s dostupnim podacima na QCD rešetci možemo testirati univerzalnost leptonskih okusa u tim raspadima i precizno testirati Standardni model. Sveukupno, ovo istraživanje doprinosi našem razumijevanju neperturbativnih svojstava QCD-a u raspadima teških mezona, pružajući vrijedne uvide u Standardni model i izvan njega.]]></summary_hr><summary_en><![CDATA[Achieving the precision necessary for a full understanding of heavy flavour physics requires a grasp of nonperturbative QCD (Quantum Chromodynamics) in heavy meson decays. Therefore, in this project, we delve into the nonperturbative QCD properties of certain heavy meson decays, pursuing research along two primary directions. In the first direction, we investigate nonperturbative QCD effects by using the method of nonlocal condensates in processes which are especially sensitive to underlying nonperturbative dynamics -  in mixing of D0 neutral mesons and in rare D-meson decays.  We aim to resolve a significant discrepancy between the measured D0-meson mixing parameters and their perturbative predictions which suggest a four orders of magnitude smaller result. Using the same method, we will pinpoint the nonperturbative QCD effects in rare D-meson decays which are influenced by underpinned nonperturbative dynamics, thereby offering predictions for present and future colliders. Secondly, our research focuses on understanding nonperturbative dynamics in selected heavy-to-light B- and D-meson decays, with the aim of overconstraining the Vub (and Vcd) CKM matrix element. This will be achieved by accurate determination of form factors using the light-cone sum rule method. Additionally, investigating B(s), D(s) -> eta, eta’ semileptonic decays enables us not only to determine precise branching ratios for these decays and extract CKM matrix elements, but also to extract the eta-eta’ mesons mixing angle. By combining the obtained form factors with available lattice QCD data, we can test lepton flavour universality in these decays and probe the Standard Model with great precision.Overall, this research contributes to our understanding of nonperturbative QCD properties in heavy meson decays, providing valuable insights into the Standard Model and beyond.]]></summary_en></project><project>
<id>16636</id><title_hr><![CDATA[Rani bihevioralni markeri neurorazvojnih odstupanja vidno-prostorne obrade i vidno-motoričke integracije u nedonoščadi]]></title_hr><title_en><![CDATA[Early behavioural markers for developmental alterations in visuospatial processing and visual-motor integration in preterm infants]]></title_en><user_id>12564</user_id><user_firstLast_name>Ana Katušić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2024-05</proposal_call><code>IP-2024-05-3090</code><acronim><![CDATA[PRE-VISOR]]></acronim><duration>20.12.2024 - 19.12.2027</duration><status>U tijeku</status><financ_value>133.800,00 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Edukacijsko-rehabilitacijske znanosti, Psihologija, </scie_field_hr><scie_field_en>Physical education and rehabilitation sciences, Psychology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Edukacijsko-rehabilitacijski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Education and Rehabilitation Sciences]]></institution_en><team_members_id>26342, 12660, 867808, 12740, 23535, 23700, 868185, 867873, 868034, 872890, </team_members_id><team_members_names><![CDATA[Sonja Alimović, Ana-Marija Bohaček, Andrea Paulik, Mirna Kostović Srzentić, Ruža Grizelj, Nada Sindičić Dessardo, Vedran Jurdana, Pasquale Anthony Della Rosa, Cristina Fernandez-Baizan, Bruna Bašić, ]]></team_members_names><keywords_hr><![CDATA[vidno-prostorna obrada, vidno-motorička integracija, nedonoščad, spontani pokreti, vidne funkcije, bihevioralni markeri]]></keywords_hr><keywords_en><![CDATA[visuospatial processing, visual-motor integration, preterm infants, general movements, visual function, behavioural markers]]></keywords_en><summary_hr><![CDATA[Nedonošenost se uglavnom povezuje s teškim neurorazvojnim poremećajima. Međutim, blagi neurorazvojni poremećaji koji uglavnom uključuju kognitivne deficite u vidno-prostornoj obradi i vidno-motoričkoj integraciji često se primjećuju u nedonoščadi. Učestalost vidno-prostornih i vidno-motoričkih teškoća u ovoj populaciji je visoka i &#39;&#39;izvan radara&#39;&#39; neurorazvojnog praćenja. Ovi deficiti predstavljaju trajnu kognitivnu disfunkciju koja utječe na adaptivno ponašanje i obrazovni uspjeh, a zapanjujuće su uočeni i kod nedonoščadi bez ili s blagim perinatalnim oštećenjem mozga kod kojih je predikcija razvojnog ishoda najzahtjevnija. Stoga postoji jasna potreba za istraživanjem bihevioralnih markera u podlozi ovih specifičnih kognitivnih deficita. Vidno-prostorne i vidno-motoričke funkcije razvijaju se rano i regulirane su opsežnom neurološkom mrežom koja se u ranoj dobi odražava motoričkim i vidnim ponašanjem. Promjene u ranim motoričkim i vidnim funkcijama refleksije su neurološke reorganizacije i temelj kaskade kognicije. Ovaj projekt će analizirati funkcije prominentnih ranih ponašanja, spontane pokretljivosti i gledanja, za koje smatramo da su u osnovi razvoja vidno-prostornih i vidno-motoričkih funkcija. Glavni je cilj projekta definirati rane bihevioralne markere za razvojna odstupanja u vidno-prostornoj obradi i vidno-motoričkoj integraciji kod nedonoščadi. Uzorak će činiti vrlo nedonošena dojenčad bez ili s blagim oštećenjem mozga. Kvaliteta spontane pokretljivosti i funkcija fiksacije i praćenja vidnih meta procijenit će se u novorođenačkoj i dojenačkoj dobi. Vidno-prostorne i vidno-motoričke funkcije ispitat će se bihevioralnim testovima i metodom praćenja pokreta oka u 3. godini. Pristup strojnog učenja koristit će se za prepoznavanje ranih značajki ponašanja relevantnih za predviđanje ishoda. Naši će rezultati razjasniti odnos između ranog motoričkog i vidnog ponašanja i razvoja specifičnih kognitivnih domena te ukazati na potencijalne bihevioralne prediktore.]]></summary_hr><summary_en><![CDATA[Prematurity is usually matched with severe neurodevelopmental disorders. Still, also mild neurodevelopmental disorders, mainly involving cognitive deficits in visuospatial processing and visual-motor integration are commonly noted in preterm infants. The frequency of visuospatial and visual-motor deficits in this population is high and “off the radar” of neurodevelopmental monitoring. Such deficits can imply permanent cognitive dysfunction affecting adaptive behavior and academic outcomes and are strikingly observed also in preterm infants with no or mild perinatal brain injury in which prediction of developmental outcome is challenging. Hence, there is a clear need to explore behavioral markers underlying these specific cognitive deficits. Visuospatial and visual-motor functions develop early and are regulated by an extensive neurological network that is reflected in motor and visual behavior at an early age. Changes in early motor and visual functions reflect this neurological reorganization and are the basis of cognition. This project will analyze functions of prominent early behaviors, spontaneous motility and looking, which we believe underly visuospatial and visual-motor development. The main goal is to define early behavioral markers for developmental alterations in visuospatial processing and visual-motor integration in preterm infants. The sample will consist of very preterm infants with no or mild brain injury. The quality of spontaneous motility and the function of fixation and tracking of visual targets will be assessed in newborn and infant age. Visuospatial and visual-motor functions will be evaluated with behavioral tests and the eye-tracking method in the 3rd year. A Machine Learning approach will be used to identify early behavioral features relevant to outcome prediction. Our results will clarify the link between early motor and visual behavior and the development of specific cognitive domains and indicate potential behavioral predictors.]]></summary_en></project><project>
<id>16641</id><title_hr><![CDATA[Međuodnos neuronalnog gangliozidoma i mitohondrijskog energetskog metabolizma]]></title_hr><title_en><![CDATA[Neuronal gangliosidome and mitochondrial energy metabolism interplay]]></title_en><user_id>12492</user_id><user_firstLast_name>Kristina Mlinac Jerković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2024-05</proposal_call><code>IP-2024-05-2453</code><acronim><![CDATA[NEUROGEM]]></acronim><duration>15.12.2024 - 14.12.2027</duration><status>U tijeku</status><financ_value>199.855,00 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>19078, 867913, 19043, 12600, 411, 26530, 866132, 867910, 867846, 19405, 858430, 872959, 872987, </team_members_id><team_members_names><![CDATA[Vladimir Damjanović, Ica Raluca, Katarina Ilic, Svjetlana Kalanj Bognar, Nikolina  Maček Hrvat, Borna Puljko, Ronald Schnaar, Alina Zamfir, Mirela Sarbu, Rodrigo Herrera Molina, Ana Ujević, Adriana Lipovčić, Eva Josić, ]]></team_members_names><keywords_hr><![CDATA[gangliozidi, glikosfingolipidi, energetski metabolizam mozga, ionski transporteri, ATPaza]]></keywords_hr><keywords_en><![CDATA[gangliosides, glycosphingolipids, brain energy metabolism, ion transporters, ATPase]]></keywords_en><summary_hr><![CDATA[Biosinteza gangliozida, dominantnih odrednica glikoma mozga sisavaca, je složen proces u koji su uključene specifične glikoziltransferaze. Upravo su mutacije u genima za pojedine glikoziltransferaze uzrok bolesti svrstanih u skupinu urođenih poremećaja glikozilacije (UPG). Međutim, još nije razjašnjena patološka kaskada koja povezuje genski uvjetovane poremećaje sinteze gangliozida s njihovim molekularnim i kliničkim fenotipom obilježenim mitohondrijskom disfunkcijom, epileptičkim napadajima, zastojem u razvoju i kognitivnim zaostajanjem. Opisani molekularni fenotip UPG jasno ukazuje na povezanost gangliozida s mitohondrijskim metabolizmom, stoga je jedan od ciljeva projekta provesti detaljnu strukturnu karakterizaciju gangliozida mitohondrijskih membrana i reinterpretirati uvriježeno stajalište o gangliozidima kao količinski i funkcionalno zanemarivim sastojcima mitohondrijskih membrana. Glavni cilj je razjasniti kako promjena sastava gangliozida stanične i mitohondrijske membrane dovodi do mitohondrijske disfunkcije i poremećaja u energetskom metabolizmu neurona. U tu svrhu koristit ćemo ciljanu inaktivaciju gena uključenih u biosintezu gangliozida pomoću CRIPSR-Cas9 tehnologije in vitro čime ćemo generirati biblioteke izogeničnih stanica s različitim sastavom gangliozida. U tako modificiranim ljudskim i mišjim neuronalnim staničnim linijama pratit ćemo izražaj i aktivnost odabranih ionskih transportera, enzima i proteina energetskog metabolizma stanice, koncentraciju odabranih metabolita i iona te fiziološku funkcionalnost mitohondrija. Uspostavljanje ovih staničnih linija predstavlja vrijedan resurs dostupan za istraživanja uloga gangliozida izvan okvira predloženog projekta. Projekt će doprinijeti razumijevanju molekularnog mehanizma uključenog u razvoj urođenih poremećaja glikozilacije, a jedan od očekivanih rezultata je identifikacija potencijalnih novih terapijskih ciljeva u neurološkim poremećajima praćenima narušenom homeostazom energetskog metabolizma.]]></summary_hr><summary_en><![CDATA[Gangliosides, considered as dominant determinants of the mammalian brain glycome, are synthesized in a complex process requiring specific glycosyltransferases. Certain congenital disorders of glycosylation (CDGs) are caused by gene mutations of several of these glycosyltransferases. However, clarification of the pathological cascade linking genetic disorders of ganglioside synthesis to their molecular and clinical phenotype, characterized by mitochondrial dysfunction, epileptic seizures, and delayed physical and cognitive development, is still not elucidated. Since described CDGs’ molecular phenotype speaks in favour of gangliosides being involved in mitochondrial metabolism, one of the project goals is to structurally characterize gangliosides of the mitochondrial membranes and to offer a reinterpretation of the standpoint about gangliosides as functionally negligible constituents of mitochondrial membranes. The main project objective is to determine how altered gangliosidome of cellular and mitochondrial membranes leads to mitochondrial dysfunction and neuronal energy metabolism disturbances. For this purpose, we will use targeted inactivation of ganglioside biosynthetic genes by CRIPSR-Cas9 technology in vitro, generating sublibraries of isogenic cells with different ganglioside composition. In the modified neuronal human and murine cell lines we will analyse the expression and activity of selected ion transporters, enzymes and proteins involved in cell energy metabolism, the concentration of metabolites and ions, and physiological mitochondrial function. The establishment of the proposed cell lines represents a valuable resource for long-term research of ganglioside physiological roles beyond the scope of the project. The project will contribute to clarification of the molecular mechanism underlying CDGs and ultimately lead to the identification of potential new therapeutic targets in neurological disorders accompanied by impaired energy metabolism homeostasis.]]></summary_en></project><project>
<id>16643</id><title_hr><![CDATA[ Mikroorganizmi kao izvor novih klasa antibiotika – Od totalne sinteze do novog kemijskog prostora i metodologije]]></title_hr><title_en><![CDATA[Microorganisms as source of new antibiotics -  From total synthesis to new chemical space and methodology]]></title_en><user_id>12766</user_id><user_firstLast_name>Nikola Cindro</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2024-05</proposal_call><code>IP-2024-05-5352</code><acronim><![CDATA[MicroSynTotal]]></acronim><duration>01.06.2025 - 31.05.2028</duration><status>U tijeku</status><financ_value>199.425,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>26869, 3260, 27624, 19438, 21393, 861708, 3215, 873034, </team_members_id><team_members_names><![CDATA[Nikolina Vidović, Katarina Pičuljan, Jurica Baranašić, Alma Ramić, Dajana Barišić, Gregor Talajić, Marija Alešković, Marin Knežević, ]]></team_members_names><keywords_hr><![CDATA[sinteza, antibiotici, prirodni spojevi, totalna sinteza, biološka aktivnost]]></keywords_hr><keywords_en><![CDATA[synthesis, antibiotics, natural products, total synthesis, biological activity]]></keywords_en><summary_hr><![CDATA[Antimikrobna rezistencija predstavlja značajan problem u globalnom zdravstvenom sustavu. Jedno od rješenja je razvoj novih sintetskih analoga već postojećih klasa antibiotika, međutim bakterije puno lakše modificiraju svoje mehanizme rezistencije na takvim spojevima. Dugoročnije rješenje ovoga problema nalazimo u razvoju novih klasa antimikrobnih spojeva. U sklopu ovog projekta bit će po prvi puta sintetizirani predstavnici triju klasa spojeva koji su prethodno izolirani iz prirodnog materijala, strukturno okarakterizirani, te im je in vitro određena značajna antimikrobna aktivnost, pogotovo za neke rezistentne bakterijske sojeve. Na sintetiziranim spojevima provest će se antimikrobna ispitivanja kako bi se potvrdila njihova aktivnost na širem bakterijskom panelu. Tri klase nedavno otkrivenih spojeva koje će biti obuhvaćene ovim projektom su:a) Enceleamicinib) Modificirani Cihunamidic) Kalofikolidi i bromofikolidiPrilikom razvoja sintetskih pristupa za pojedine klase spojeva također će se razvijati i nova sintetska metodologija za određeni strukturni motiv te klase, u svrhu razvoja robusnog pristupa problematičnim strukturnim fragmentima. Neke od metodologija koje će se razvijati su dupla Grignardova reakcija bazirana na adiciji različitih organometalnih reagensa i mehanokemijska ciklizacija oligopeptida. Osim toga planira se i sinteza strukturnih analoga u svakoj od navedenih skupina kako bi se provela SAR (Structure-Activity Relationship) istraživanja na navedenim klasama spojeva.]]></summary_hr><summary_en><![CDATA[Antimicrobial resistance poses a significant problem in the global healthcare system. One solution is the development of new synthetic analogs of existing classes of antibiotics; however, bacteria can more easily modify their resistance mechanisms to such compounds. A longer-term solution to this problem lies in the development of new classes of antimicrobial compounds. As part of this project, representatives of three classes of compounds, previously isolated from natural sources, structurally characterized, and showing significant in vitro antimicrobial activity, especially against some resistant bacterial strains, will be synthesized for the first time. Antimicrobial testing will be conducted on the synthesized compounds to confirm their activity on a broader bacterial panel. The three classes of recently discovered compounds to be included in this project are:a) Enceleamycinsb) Modified Cihunamidesc) Callophycoic and Bromophycoic acidsDuring the development of synthetic approaches for individual classes of compounds, new synthetic methodology will also be developed for specific structural motifs of that class, aiming to develop a robust approach to problematic structural fragments. Some of the methodologies to be developed include double Grignard reactions based on the addition of various organometallic reagents to lactones and mechanochemical cyclization  reactions of oligopeptides. Additionally, the synthesis of structural analogs in each of the mentioned groups is planned to enable SAR (Structure-Activity Relationship) studies on these classes of compounds.]]></summary_en></project><project>
<id>16647</id><title_hr><![CDATA[Mehanizmi prilagodbe diobenog vretena na različite veličine genoma]]></title_hr><title_en><![CDATA[Mechanisms of mitotic spindle&#39;s adaptation to different genome sizes]]></title_en><user_id>11207</user_id><user_firstLast_name>Iva Tolić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2024-05</proposal_call><code>IP-2024-05-5336</code><acronim><![CDATA[SpinGen]]></acronim><duration>20.12.2024 - 19.12.2027</duration><status>U tijeku</status><financ_value>199.525,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, Fizika, </scie_field_hr><scie_field_en>Biology, Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>868216, 868278, 13281, </team_members_id><team_members_names><![CDATA[Lovro Gudlin, Mario Đura, Maja Novak, ]]></team_members_names><keywords_hr><![CDATA[diobeno vreteno, mitoza, stanična dioba, kromosomi, mikrotubule, evolucija, eukarioti]]></keywords_hr><keywords_en><![CDATA[mitotic spindle, mitosis, cell division, chromosomes, microtubule, evolution, eukaryotes]]></keywords_en><summary_hr><![CDATA[Eukarioti dijele svoj genom koristeći diobeno vreteno, molekularni mikrostroj građen na uglavnom očuvanim biokemijskim i biofizikalnim principima. Bez obzira na složenost organizma, vretena su sastavljena od mikrotubula, motornih proteina i kinetohora koje poravnavaju kromosome u metafaznu ploču. Veličina vretena varira otprilike 2 reda veličine među eukariotskim organizmima. Nasuprot tome, veličina genoma obuhvaća više od 4 reda veličine. Ova razlika u skalama, gdje se veličina genoma razlikuje 100 puta više od veličine vretena, motivacija je za glavno istraživačko pitanje ovog projekta: Kako vretena slične veličine i arhitekture dijele kromosome koji sadrže genome vrlo različitih veličina? Predlažemo dva konceptualno različita modela, gdje u prvom modelu veličina i oblik vretena proizlaze iz sila guranja kromosoma unutar metafazne ploče, dok su u drugom modelu dimenzije vretena određene fiksnim kutovima pod kojim mikrotubuli izlaze iz centrosoma. Da bismo testirali te modele, koristit ćemo interdisciplinarni pristup koji obuhvaća staničnu biologiju, naprednu mikroskopiju, biofizikalne eksperimentalne pristupe i teorijsku fiziku. Provest ćemo pokuse na ljudskim stanicama kojima ćemo istražiti kako se dimenzije vretena mijenjaju kada se broj kromosoma izmijeni korištenjem novih pristupa, ili kada se smanji krutost kromosoma. Komprimirat ćemo stanice kako bismo istražili utjecaj vanjskih sila na veličinu i oblik vretena. Potaknuti rezultatima pokusa, razvit ćemo teorijski model kojim ćemo istražiti ulogu kromosoma i mikrotubula u silama odgovornim za geometriju vretena. Uzimajući u obzir širu perspektivu, naši preliminarni podaci otkrivaju zakonitosti u skaliranju diobenog vretena kod eukariota gdje se promjer metafazne ploče skalira s veličinom genoma. Stečena saznanja koristit ćemo da bismo objasnili skaliranje te identificirali očuvane mehanizme kojima se vreteno prilagođuje veličini genoma od kvasaca do biljaka i životinja.]]></summary_hr><summary_en><![CDATA[Eukaryotes divide their genome using the mitotic spindle, a molecular micro-machine built upon largely conserved biochemical and biophysical principles. Regardless of the organism&#39;s complexity, spindles are made up of microtubules, motor proteins, and kinetochores, which align the chromosomes in the metaphase plate. The spindle size varies about 2 orders of magnitude over eukaryotic organisms. In contrast, the genome size covers more than 4 orders of magnitude. This difference in scales, where the genome size differs 100 times more than the spindle size, is the motivation for the main research question of this project: How do the spindles of rather similar size and architecture divide chromosomes from genomes of very different sizes? We propose two conceptually different models, where in the first one spindle size and shape result from chromosome pushing forces within the metaphase plate, whereas in the second one spindle dimensions are set by centrosomal microtubule clamping. To test these models, we will take an interdisciplinary approach encompassing cell biology, advanced microscopy, and biophysical perturbations, with help from theoretical physics. We will perform experiments on human cells to investigate how the spindle dimensions change when the chromosome number is altered by using novel approaches, or when the chromosome stiffness is decreased. We will compress the cells to explore how external force affects the spindle size and shape. Inspired by the experimental results, we will develop a theoretical model to explore the role of chromosome- and microtubule-based forces in setting the spindle geometry. Taking a broader perspective, our preliminary data reveal a spindle scaling law across eukaryotes where the metaphase plate diameter shows a power-law scaling with the genome size. We will use the insights gained here to explain this scaling law and to identify the conserved mechanisms of spindle adaptation to genome size from yeasts to plants and animals.]]></summary_en></project><project>
<id>16655</id><title_hr><![CDATA[Istraživanje prostornog planiranja u neolitiku Slavonije neinvazivnim arheološkim metodama]]></title_hr><title_en><![CDATA[Non-invasive archaeological research of landscape planning in Neolithic Slavonia]]></title_en><user_id>25165</user_id><user_firstLast_name>Rajna Šošić Klindžić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2024-05</proposal_call><code>IP-2024-05-1598</code><acronim><![CDATA[ISPRAN]]></acronim><duration>09.12.2024 - 08.12.2027</duration><status>U tijeku</status><financ_value>199.997,50 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Arheologija, Interdisciplinarne humanističke znanosti, </scie_field_hr><scie_field_en>Archeology, Interdisciplinary humanities, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>5386, 7392, 7577, 26639, 867934, 13425, 27049, 1354, </team_members_id><team_members_names><![CDATA[Giovanni Boschian, Hrvoje Kalafatić, Bartul Šiljeg, Martina Rončević, Dimitrij Mlekuž Vrhovnik, Maja Krznarić Škrivanko, Boban Tripković, Jasna Orešković, ]]></team_members_names><keywords_hr><![CDATA[arheologija, lasersko zračno skeniranje, satelitske snimke, magnetometrija, neolitik, Slavonija]]></keywords_hr><keywords_en><![CDATA[Archaeology, Airborne laser scanning, Aatellite imagery, Magnetic survey, Neolithic, Slavonia]]></keywords_en><summary_hr><![CDATA[Glavni cilj projekta je utvrditi stvarni prosječni opseg, izgled i infrastrukturu neolitičkih naselja u Slavoniji korištenjem neinvazivnih arheoloških metoda daljinskog istraživanja i magnetske prospekcije. Kroz projekt će se provoditi analiza snimaka zračnog laserskog skeniranja i satelitskih snimaka. Prema rezultatima analize tih snimaka odabrat će se lokaliteti na kojima će se provoditi magnetometrijska snimanja velikog opsega u svrhu dobivanja tlocrta naselja. Na dosada nepoznatim lokalitetima pronađenim ovim istraživanjima će se provoditi terenski pregledi i otvarati male testne sonde u svrhu potvrde kronološke atribucije. Važni cilj je multidisciplinarnim geoarheološkim uzorkovanjima i analizama uključiti u interpretaciju i pitanje u kojoj mjeri je antropogeni utjecaj na akumulaciju sedimenata ujedno i utjecaj na mikroreljef, na što upućuju preliminarni podaci naših nedavno objavljenih istraživanja. Na temelju novih podataka dobivenih korištenjem suvremene tehnologije i metoda prirodnih znanosti propitivat će se ustaljeni zaključci o načinu života u neolitiku i ponuditi nove mogućnosti analize, interpretacije i smjerova istraživanja. Korištenje navedenih tehnologija i metoda za neinvazivno arheološko istraživanje unutar ovog projekta omogućit će uočavanje arheoloških ostataka i precizno atribuiranje na jako velikom području u razmjerno kraćem vremenu, te znatno pridonijeti poznavanju, zaštiti i očuvanju kulturne baštine, uz nove mogućnosti interpretacije. Projektom će se potvrditi učinkovitost korištenja tehnoloških i znanstvenih dostignuća kao vrijednog i nezaobilaznog doprinosa humanističkih istraživanja usmjerenim ka odgovorima na pitanja o načinu života ljudi u neolitiku.  ]]></summary_hr><summary_en><![CDATA[The project aims to determine the average extent, layout and infrastructure of Neolithic settlements in Slavonia using non-invasive archaeological methods of remote sensing and magnetic surveying. The analysis of airborne laser scanning and satellite images will be carried out through the project. Based on the results of analyzing these images, we will select sites for large-scale magnetic surveys to obtain the ground plan of the settlements. We will conduct field surveys and use small test trenches at previously unknown sites to confirm their chronological attribution. An important goal of the project is to use multidisciplinary geoarchaeological sampling and analysis to include in the interpretation the question to what extent the anthropogenic influence on the accumulation of sediments can also be an influence on the microrelief, as indicated by the preliminary data of our recently published research. Based on the new data obtained using modern technology and methods of natural sciences, established conclusions about the way of life in the Neolithic will be questioned and new possibilities of analysis, interpretation and directions of research will be offered. The use of the aforementioned technologies and methods for non-invasive archaeological research within this project will enable the observation of archaeological remains and precise attribution over a very large area in a relatively short time, and will significantly contribute to the knowledge, protection and preservation of cultural heritage, with new interpretation possibilities. The project will confirm the potential of using technological and scientific achievements as a valuable and indispensable contribution of humanistic research aimed at answering questions about the life of people in the Neolithic period.]]></summary_en></project><project>
<id>16660</id><title_hr><![CDATA[Praćenje antimikrobne rezistencije analizom podzemnih voda]]></title_hr><title_en><![CDATA[Antimicrobial resistance surveillance via analyses of groundwaters]]></title_en><user_id>12566</user_id><user_firstLast_name>Nikolina Udiković Kolić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2024-05</proposal_call><code>IP-2024-05-7387</code><acronim><![CDATA[ARES]]></acronim><duration>10.12.2024 - 09.12.2027</duration><status>U tijeku</status><financ_value>199.602,93 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Biotehnologija, Interdisciplinarne biotehničke znanosti, </scie_field_hr><scie_field_en>Biotechnology, Interdisciplinary biotechnical sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>857304, 4001, 5731, 19544, 867823, 4429, 22532, 872873, 873058, </team_members_id><team_members_names><![CDATA[Ana Puljko, Marko Jelić, Ana Maravić, Ivan Barisic, Masaki Shintani, Magdalena Ujević Bošnjak, Jurica  Štiglić, Louis Weisse, Josipa Pečnik, ]]></team_members_names><keywords_hr><![CDATA[antimikrobna rezistencija, podzemne vode, patogeni, rezistentni geni, enterobakterije]]></keywords_hr><keywords_en><![CDATA[antimicrobial resistance, groundwaters, pathogens, antibiotic resistance genes, enterobacteria]]></keywords_en><summary_hr><![CDATA[Antimikrobna rezistencija (AMR) jedna je od najvećih prijetnji ljudskom zdravlju i zahtijeva integrirani pristup One Health za temeljito istraživanje i kontrolu. Međutim, nadzor AMR-a kod bakterija ograničen je na kliničko okruženje kako u Hrvatskoj tako i u svijetu, dok se malo pozornosti posvećuje okolišu. Unatoč važnoj ulozi podzemne vode kao izvora opskrbe pitkom vodom, njezin doprinos globalnoj AMR krizi još je uvelike neistražen. Kako bi popunio ovu prazninu, projekt ARES usvojit će holistički, interdisciplinarni pristup za istraživanje rezistoma, mikrobioma i mobiloma četiri izvorišta podzemne vode, uključujući tri krška izvorišta koji se koriste za vodoopskrbu u Hrvatskoj. Primijenit ćemo metode neovisne o uzgoju mikroorganizama kao što su qPCR čipovi u kombinaciji sa sekvenciranjem amplikona 16S rRNA gena kako bismo istražili rezistom i mikrobiom podzemne vode kroz različite sezone. To će nam omogućiti procjenu vremenskih trendova u raznolikosti i brojnosti mikrobioma i rezistoma u proučavanim izvorištima. Osim toga, koristit ćemo pristupe ovisne o uzgoju za procjenu AMR profila klinički važnih patogena (Escherichia coli, Klebsiella pneumoniae, Acinetobacter baumanii, Pseudomonas aeruginosa i Enterococcus spp.) koje ćemo izolirati iz podzemnih voda. Primjenom metode sekvenciranja cijelog genoma, istražit ćemo molekularne mehanizme rezistencije i potencijalnu patogenost ovih izolata. Naposljetku, hvatanje rezistentnih plazmida direktno iz bakterija podzemne vode u E. coli i njihovo naknadno potpuno sekvencioniranje bit će presudno za donošenje zaključaka o potencijalnoj razmjeni AMR-a između okolišnih rezervoara i ljudske populacije. Vjerujemo da će dobivena saznanja pružiti važne uvide za razvoj strategija upravljanja usmjerenih na smanjenje pojave i širenja AMR-a putem rezervoara pitke vode.]]></summary_hr><summary_en><![CDATA[Antimicrobial resistance (AMR) is one of the greatest threats to human health and requires a comprehensive One Health approach for thorough investigation and control. However, surveillance of AMR in bacteria is limited to the clinical setting both in Croatia and worldwide, while little attention is paid to the environment. Despite the important role of groundwater as a drinking water supply, its contribution to the global AMR crisis is still largely unexplored. To fill this gap, the ARES project will adopt a holistic, interdisciplinary approach to investigate the resistome, microbiome and mobilome of four groundwater sources, including three karst sources used for water supply in Croatia. We will apply culture-independent methods such as high-throughput qPCR arrays and standard qPCR in combination with 16S rRNA amplicon sequencing to investigate the resistome and microbiome of groundwater over several seasons. This will allow us to assess temporal trends in the diversity and abundance of the microbiome and resistome in the studied groundwater sources. In addition, we will use culture-dependent approaches to assess the AMR profile of clinically important pathogens (Escherichia coli, Klebsiella pneumoniae, Acinetobacter baumanii, Pseudomonas aeruginosa and Enterococcus spp.) isolated from groundwater and investigate the molecular mechanisms of their resistance and virulence potential using whole-genome sequencing. Finally, the direct capture of antibiotic-resistant plasmids from groundwater bacteria to E. coli and their subsequent complete sequencing will be crucial to draw conclusions on the potential exchange of AMR between environmental reservoirs and the community. We believe that this knowledge will provide important insights for management strategies aimed at mitigating the emergence and spread of AMR and important human pathogens via drinking water reservoirs.]]></summary_en></project><project>
<id>16664</id><title_hr><![CDATA[Parcijalna dealkoholizacija vina primjenom membranskih procesa napredne i reverzne osmoze kao odgovor na klimatske izazove]]></title_hr><title_en><![CDATA[Partial dealcoholization of wine using membrane processes of forward and reverse osmosis as a response to climate challenges]]></title_en><user_id>13272</user_id><user_firstLast_name>Natka Ćurko</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2024-05</proposal_call><code>IP-2024-05-3844</code><acronim><![CDATA[FoRoClimaWINE]]></acronim><duration>09.12.2024 - 08.12.2027</duration><status>U tijeku</status><financ_value>199.360,00 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Prehrambena tehnologija, Interdisciplinarne biotehničke znanosti, </scie_field_hr><scie_field_en>Food technology, Interdisciplinary biotechnical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Food Technology and Biotechnology]]></institution_en><team_members_id>6224, 5739, 5719, 13282, 868202, 873104, 21346, </team_members_id><team_members_names><![CDATA[Karin Kovačević Ganić, Josip Ćurko, Marin Matošić, Leo Gracin, Pierre-Louis Teissedre, Irena Zanini, Manuela Panić, ]]></team_members_names><keywords_hr><![CDATA[reverzna osmoza, napredna osmoza, dealkoholizacija, kvaliteta vina, klimatske promjene]]></keywords_hr><keywords_en><![CDATA[reverse osmosis, forward osmosis, dealcoholization, wine quality, climate changes]]></keywords_en><summary_hr><![CDATA[Prilagođavanje posljedicama klimatskih promjena, kroz unaprjeđenje postojećih tehnologija i razvoj novih, jedan je od ključnih enoloških izazova. Negativan utjecaj klimatskih djelovanja razvidan je i kroz povećanje udjela alkohola u vinu od čak 3-4 % vol. tijekom posljednja tri desetljeća, što danas rezultira vinima s 15 i više % vol. alkohola. Visoki udjeli alkohola imaju izrazito negativan utjecaj na senzorske karakteristike vina, a uzrokuju povećanje osjeta „žarenja“ i „paljenja“, povećanje gorčine, ali i smanjenje kompleksnosti arome, voćnosti te ukupne harmoničnosti. Enološke metode dealkoholizacije najčešće uključuju primjenu membranskih procesa poput reverzne osmoze, ali zahtijevaju daljnju optimizaciju s ciljem umanjenja utjecaja na kemijske i senzorske karakteristike vina. S druge strane, mogućnosti napredne osmoze kao novog membranskog procesa dealkoholizacije vina su u potpunosti neistražene. Alternativne enološke strategije uključuju fermentaciju s low alcohol Saccharomyces ili non-Saccharomyces kvascima te smanjenje alkohola za -2 % vol., dok je njihov utjecaj na kemijske i senzorske karakteristike vina manje poznat. Cilj ovog projekta je istražiti različite metode smanjenja udjela alkohola u vinu uključujući membranske procese reverzne osmoze i napredne osmoze, biološki proces fermentacije s low alcohol Saccharomyces cerevisiae kvascem te kombinaciju bioloških i membranskih procesa, temeljem njihovog utjecaja na kemijski sastav (aroma i polifenolni spojevi) i senzorske karakteristike vina. Također, odredit će se i dugoročan efekt navedenih procesa tijekom dozrijevanja i starenja u bocama na kvalitetu vina. Rezultati ovog projekta omogućit će usporedbu novog membranskog postupka napredne osmoze s reverznom osmozom, pojedinačno te u kombinaciji s biološkim postupkom. Temeljem navedenog odabrat će optimalan proces i parametri parcijalne dealkoholizacije vina uz očuvanje njegove arome, polifenolnog sastava i senzorske kompleksnosti.]]></summary_hr><summary_en><![CDATA[Mitigating and adapting to climate changes, by improving existing and developing new technologies is one of the most important enological challenges. The negative effects of climate are reflected in an increase in the alcohol content of wine by 3-4% vol. over the last three decades, today resulting in wines exceeding 15% vol. High alcohol content negatively affects sensory attributes of wine by increasing the perception of &#39;&#39;hotness&#39;&#39; and &#39;&#39;burning&#39;&#39;, increasing bitterness and reducing aroma complexity, fruitiness and overall harmony. Enological dealcoholization methods usually involve the use of membrane processes such as reverse osmosis, but require further optimization to minimize their impact on wine chemical and sensory characteristics. On the other hand, the potential of forward osmosis as a new membrane process for wine dealcoholization is still largely unexplored. Alternative enological strategies such as fermentation with low alcohol Saccharomyces or non-Saccharomyces yeasts can reduce alcohol content by -2% vol., but their effect on the chemical and sensory characteristics of wine is less known. The aim of this project is to study the effects of different partial dealcoholization methods, including the membrane processes of reverse osmosis and forward osmosis, the biological process of fermentation with low alcohol Saccharomyces cerevisiae yeast and the combination of biological and membrane processes, on the chemical composition (aroma and polyphenolic compounds) and sensory characteristics of wine. In addition, the long-term effects of these processes on wine quality during maturation and aging in bottles will be determined. The results will enable the comparison among forward osmosis, a novel membrane process, and reverse osmosis, both separately and combined with the biological process. Finally, the optimal process and its parameters for the partial dealcoholization of wine sustaining aroma, polyphenolic composition and sensory complexity will be defined.]]></summary_en></project><project>
<id>16669</id><title_hr><![CDATA[Ugađanje kritičnosti u jako koreliranim materijalima primjenom ekstremnih uvjeta]]></title_hr><title_en><![CDATA[Criticality in strongly correlated materials tuned under extreme conditions]]></title_en><user_id>3159</user_id><user_firstLast_name>Mihael Srđan Grbić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2024-05</proposal_call><code>IP-2024-05-4586</code><acronim><![CDATA[Critical-Tex]]></acronim><duration>20.12.2024 - 19.12.2027</duration><status>U tijeku</status><financ_value>186.338,92 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>50, 25857, 866065, 866252, </team_members_id><team_members_names><![CDATA[Miroslav Požek, Ivan Jakovac, Karl W. Kraemer, Norbert Buettgen, ]]></team_members_names><keywords_hr><![CDATA[frustracija, kvantne spinske tekućine, nuklearna magnetska rezonancija, kvantni magnetizam, visoki tlak]]></keywords_hr><keywords_en><![CDATA[frustration, quantum spin liquid, nuclear magnetic resonance, quantum magnetism, high pressure]]></keywords_en><summary_hr><![CDATA[Tehnološki napredak kojeg smo svjedoci u proteklom desetljeću ima isto zajedničko podrijetlo – razvoj novih materijala i tehnologije proizvodnje. Prednost proučavanja jako koreliranih sustava (SCES) je u tome što omogućuju otkrivanje i proučavanje novih stanja materije uz relativno male promjene u njihovom &#39;&#39;dizajnu&#39;&#39;. To je omogućeno jakim korelacijama i kvantnom prirodom interakcija, što SCES materijale čini materijalima budućnosti. Kroz proučavanje nekoliko SCES materijala u ovom projektu naučit ćemo mnogo o novim kvantnim fenomenima i pomaknuti nas korak bliže njihovoj primjenjivosti u standardnim uvjetima. Konkretno, u sklopu ovog projekta usredotočit ćemo se na proučavanje: (i) trihalida rijetkih zemalja, gdje se svojstva Van der Waalsovog dvodimenzionalnog magnetizma isprepliću sa svojstvima kvantne spinske tekućine na heksagonalnoj kristalnoj rešetci; (ii) spinela skandijevih halkogenida gdje dvostruka dijamantna rešetka stvara frustraciju i omogućuje realizaciju spin-orbitalne tekućine.  Ova nova stanja materije proučavat će se korištenjem lokalnih tehnika nuklearne magnetske i kvadrupolne rezonancije (NMR/NQR) koje imaju pristup relativno širokom rasponu temperatura, jakosti magnetskog polja i tlakova. Kako bismo proširili raspon mjernih parametara, razvit ćemo niskotemperaturni kriostat za mjerenja na temperaturama ispod 1 K. Sustav će biti kompatibilan s tlačnim ćelijama koje su već prisutne u laboratoriju. Ovaj postav će nam omogućiti tehnološki napredak kojim ćemo dobiti mikroskopske informacije u ekstremnim uvjetima (pri niskim temperaturama i visokim tlakovima) potrebne za kompletno razumijevanje problematike. Rezultat projekta će biti nekoliko članaka u časopisima visokog faktora utjecaja, te pojačanje istraživačkih kapaciteta Fakulteta.]]></summary_hr><summary_en><![CDATA[Technological advances we have been witnessing in the past decade have the same common origin – development of new materials and manufacturing technology. The advantage of studying strongly correlated systems (SCES) is that they enable the discovery and exploration of new states of matter with only minor changes in their &#39;&#39;design&#39;&#39;. This is enabled by strong correlations and quantum nature of interactions, which makes SCES materials the materials of the future. Through the study of several SCES materials in this project we will learn a lot about novel quantum phenomena and move us one step closer to their applicability under standard conditions. More specific, within this project we will focus on studying: (i) rare earth trihalides, where the properties of Van der Waals two-dimensional magnetism are intertwined with the properties of quantum spin liquid realized on a hexagonal lattice; (ii) spinels of scandium chalcogenides where a double diamond structure creates frustration and enables a spin-orbital liquid. These new states of matter will be studied using local techniques of nuclear magnetic and quadrupole resonance (NMR/NQR), which have access to a relatively wide range of temperatures, magnetic field strengths and pressures. To expand the measurement parameter range, we will develop a low-temperature cryostat for measurements at temperatures below 1 K. The setup will be compatible with high-pressure cells present in the laboratory. This will allow us technological progress to obtain multiple microscopic information under extreme conditions (low temperatures and high pressures) necessary for complete understanding of the open questions. Results of the project will be several articles in journals with a high impact factor and strengthening of the Faculty of Science&#39;s research capacity.]]></summary_en></project><project>
<id>16675</id><title_hr><![CDATA[Procjena utjecaja klimatskih promjena na turizam temeljen na prirodi: razvoj indeksa ranjivosti i otpornosti zaštićenih područja za upravljanje strategijama prilagodbe ]]></title_hr><title_en><![CDATA[Assessing climate change impact on nature-based tourism: developing protected areas vulnerability and resilience indices for managing climate change adaptation strategies]]></title_en><user_id>12794</user_id><user_firstLast_name>Izidora Marković Vukadin</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2024-05</proposal_call><code>IP-2024-05-9190</code><acronim><![CDATA[PACT-VIRA]]></acronim><duration>16.12.2024 - 15.12.2027</duration><status>U tijeku</status><financ_value>174.040,00 eur</financ_value><scie_area_hr>Interdiciplinarne znanosti, Društvene znanosti, Prirodne znanosti, Tehničke znanosti, </scie_area_hr><scie_area_en>Interdisciplinary scientific area, Social sciences, Natural sciences, Technological sciences, </scie_area_en><scie_field_hr>Geografija, Geologija, Biologija, Geofizika, Ekonomija, Interdisciplinarne prirodne znanosti, Interdisciplinarne društvene znanosti, </scie_field_hr><scie_field_en>Geography, Geology, Biology, Geophysics, Economy, Interdisciplinary natural sciences, Interdisciplinary social sciences, </scie_field_en><institution_hr><![CDATA[Institut za turizam]]></institution_hr><institution_en><![CDATA[Institute for Tourism in Zagreb]]></institution_en><team_members_id>12616, 4006, 7431, 217, 12435, 22782, 3471, 25274, 20481, 2650, 867997, 4846, 22762, 868707, 3146, 868710, 868706, 865412, </team_members_id><team_members_names><![CDATA[Mira Zovko, Hrvoje Carić, Ivo Beroš, Damir Krešić, Hrvoje Mataković, Staša Borović, Josip Terzić, Marco Pola, Tanja Likso, Ivana Herceg Bulić, Ante Mandić, Luka Valožić, Aljoša Duplić, Karla Fabrio Čubrić, Lidija Srnec, Ivana Havrle Kozarić, Tamara Kirin, Filip Ložek, ]]></team_members_names><keywords_hr><![CDATA[Klimatske promjene, turizam, zaštićena područja, pokazatelji, kompozitni indeksi, prilagodba]]></keywords_hr><keywords_en><![CDATA[Climate changes, tourism, protected areas, indicators, composite indexes, adaptation]]></keywords_en><summary_hr><![CDATA[Današnja turistička potražnja sve je više pod utjecajem vanjskih čimbenika, a klimatske promjene predstavljaju jedan od najvažnijih. Klimatske promjene su gorući globalni problem s dalekosežnim posljedicama za razne sektore, uključujući turizam. Postoji velika heterogenost u procjenama fizičkih i socio-ekonomskih utjecaja klimatskih promjena, ovisno o destinaciji i metodologiji. Klimatske promjene posebno ugrožavaju održivost turizma utemeljenog na prirodi, osobito u zaštićenim područjima, koja su često netaknuti ekosustavi i žarišta bioraznolikosti te su osjetljiva na ekstremne vremenske događaje, požare, suše, gubitak staništa i promjene u distribuciji vrsta. Turizam u zaštićenim prirodnim područjima predstavlja važan segment globalne ekonomije i ključan je za očuvanje prirodnih resursa. Međutim, s porastom klimatskih promjena, ta područja su sve više izložena prijetnjama koje mogu značajno utjecati na njihovu održivost i atraktivnost za turiste. Stoga je važno istražiti kako klimatske promjene utječu na turizam u zaštićenim područjima i razviti strategije prilagodbe koje će osigurati održivost turističkih aktivnosti.Ciljevi ovog projekta su multidisciplinarni i usmjereni na dublje razumijevanje interakcija između klimatskih promjena, turizma i očuvanja prirode. Prvi cilj je procijeniti trenutačno stanje turizma u zaštićenim područjima kako bi se identificirale ključne klimatske prijetnje. Potom će se analizirati ranjivost tih područja na klimatske promjene s posebnim fokusom na ekstremne vremenske uvjete, promjene staništa vrsta i razvoj turizma. Identifikacija relevantnih pokazatelja ranjivosti bit će ključna za praćenje i evaluaciju utjecaja klimatskih promjena. Razvojem prilagođenih indeksa ranjivosti i otpornosti, istraživanje će pridonijeti učinkovitijem upravljanju utjecajima klimatskih promjena na turizam. Krajnji cilj je osigurati dugoročnu održivost i otpornost zaštićenih područja te maksimizirati koristi turizma za lokalne zajednice i očuvanje prirode.]]></summary_hr><summary_en><![CDATA[Modern tourism demand is influenced by external factors, with climate change being one of the most significant. Climate change is a pressing global issue with far-reaching consequences for various sectors, including tourism. There is considerable heterogeneity in assessments of the physical and socio-economic impact of climate change, depending on the destination and methodology. Climate changes particularly threatens the sustainability of nature-based tourism, especially in protected areas, which are often ecosystems and biodiversity hotspots and are sensitive to extreme weather events, fires, droughts, habitat loss and changes in species distribution. Tourism in protected natural areas represents an important segment of the global economy and is crucial for conserving natural resources. However, with the increasing impact of climate changes, the areas are increasingly exposed to threats that can significantly affect their sustainability and attractiveness to tourists. Therefore, it is important to explore how climate change affects tourism in protected areas and develop adaptation strategies to ensure the sustainability of tourism activities. The goals of this project are multidisciplinary and aimed to deeper understanding the interactions between climate changes, tourism, and nature conservation. The first goal is to assess the current state of tourism in protected areas to identify key climate threats. This will be followed by an analysis of the vulnerability of these areas to climate changes, with a particular focus on extreme weather conditions, changes in species habitats and tourism development. Identifying relevant indicators of vulnerability and resiliencies indices, the research will contribute to ensure the long-term sustainability and resilience of protected areas and to maximize the socio-economic benefits of tourism for local communities and nature conservation. ]]></summary_en></project><project>
<id>16679</id><title_hr><![CDATA[Model biofortifikacije sa selenom i cinkom radi poboljšanja kvalitete ječma]]></title_hr><title_en><![CDATA[Model of biofortification with selenium and zinc towards improving barley quality]]></title_en><user_id>7747</user_id><user_firstLast_name>Zdenko Lončarić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2024-05</proposal_call><code>IP-2024-05-7551</code><acronim><![CDATA[BarleyBioFort]]></acronim><duration>18.12.2024 - 17.12.2027</duration><status>U tijeku</status><financ_value>195.251,63 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, Prehrambena tehnologija, </scie_field_hr><scie_field_en>Agriculture, Food technology, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Fakultet agrobiotehničkih znanosti Osijek]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Agrobiotechnical Sciences in Osijek]]></institution_en><team_members_id>22586, 5097, 19286, 5095, 571, 865736, 6520, 26609, 29578, </team_members_id><team_members_names><![CDATA[Miroslav Lisjak, Alojzije Lalić, Krešimir Dvojković, Gordana Šimić, Ivan Abičić, Dubravka Hefer, Marko Jukić, Jasmina Lukinac Čačić, Suzana Kristek, ]]></team_members_names><keywords_hr><![CDATA[pothranjenost, selen, cink, biofortifikacija, ječam, brašno, slad, kruh]]></keywords_hr><keywords_en><![CDATA[undernutrition, selenium, zinc, biofortification, barley, flour, malt, bread]]></keywords_en><summary_hr><![CDATA[Nedovoljne koncentracije selena i cinka u hrani biljnog podrijetla među najvažnijim su uzrocima pothranjenosti stanovništva diljem svijeta. Unos Se i Zn hranom značajan je za imunološki sustav ljudi te je pandemija COVID-a dodatno potencirala važnost Se i Zn u hrani. Povećanje koncentracije Se i Zn u poljoprivrednim proizvodima može se postići genetskom,  agronomskom i mikrobiološkom biofortifikacijom. Genetska zahtijeva dugotrajniji oplemenjivački rad kreiranja genotipova s povećanom akumulacijom Se ili Zn, a agronomska i mikrobiološka su kratkoročno učinkovitiji, ali zahtijevaju učinkovitu aplikaciju mikrognojiva i/ili mikroorganizama. U pripremnim istraživanjima skriningom 70-ak kultivara ječma utvrđene su razlike u akumulaciji Se i Zn. U prethodnim su znanstvenim istraživanjima utvrđene različite učinkovitosti biofortifikacije Se i Zn za različite usjeve i aplikacije, a utvrđen je i utjecaj mikroorganizama na akumulacija Se i Zn. Cilj je ovog istraživanja utvrditi posebnosti kultivara ječma i najučinkovitiji model agronomske i mikrobiološke biofortifikacije sa Se i Zn na temelju akumulacije u zrnu, brašnu, sladnom brašnu, ali i na temelju drugih parametara nutritivne vrijednosti (npr, udio B-glukana), parametara citolitičke i proteolitičke razgrađenosti slada te oksidativnog potencijala i kelatirajuće sposobnosti ječma. Istraživanje će biti provedeno poljskim pokusima s 8 izabranih genotipova ječma i istovremenim kontroliranim uzgojem u fitotronu na slabo kiselom, jako kiselom i alkalnom tlu s različitim agronomskim i mikrobiološkim biofortifikacijama sa Se i Zn. Specifičnost utjecaja kultivara ječma i različitih biofortifkacija na kvalitetu zrna, brašna, slada i kruha, bit će ulazne vrijednosti za kreiranje statističkih (regresijskih) modela i modela neuronskih mreža.Svrha navedenih modela bit će procjena i analiza pogodnosti kultivara ječma te agronomske i mikrobiološke biofortifikacije Se i Zn za postizanje određene namjenske kvalitete zrna i/ili proizvoda.]]></summary_hr><summary_en><![CDATA[Insufficient concentrations of Se and Zn in food of plant origin are among the most important causes of malnutrition in the population worldwide. The intake of Se and Zn in food is important for the human immune system. Increased concentration of Se and Zn in agricultural products can be achieved by genetic, agronomic and microbe mediated biofortification. Genetic requires longer-term breeding of genotypes with increased Se or Zn, while agronomic and microbe mediated are more effective in the short term, but require effective application of microfertilizers and/or microorganisms. In preliminary research, different accumulation of Se and Zn were determined by screening about 70 barley cultivars. Also, different efficiencies of crops biofortification with Se and Zn and the influence of microorganisms on Se and Zn accumulation were previously determined. The aim of this research is to determine the specificity of barley cultivars and the most effective model of agronomic and microbe mediated biofortification with Se and Zn based on grain, flour, malt flour quality, but also according to other parameters of nutritional value (e.g. B-glucan content), parameters of cytolytic and proteolytic breakdown of malt and oxidative potential and chelating ability. The research will include field experiments with 8 selected barley genotypes and simultaneous controlled cultivation in a phytotron on slightly acidic, highly acidic and alkaline soils with different agronomic and microbe mediated biofortifications with Se and Zn. The specificity of the influence of barley cultivars and different biofortifications on the quality of grain, flour, malt and bread will be the input values for the creation of statistical (regression) models and neural network models. The purpose of the aforementioned models will be the prediction and analysis of the barley cultivars and agronomic and microbe mediated biofortification with Se and Zn impact on certain grain and other product quality.]]></summary_en></project><project>
<id>16688</id><title_hr><![CDATA[Uloga proteoglikana u diferencijaciji kortikalnih sinapsi i specijalizaciji neuronskih krugova u zdravlju i perinatalnoj hipoksiji]]></title_hr><title_en><![CDATA[The role of proteoglycans in cortical synapse differentiation and specification of neuronal circuitries in health and perinatal hypoxia]]></title_en><user_id>6256</user_id><user_firstLast_name>Nataša Jovanov Milošević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2024-05</proposal_call><code>IP-2024-05-4135</code><acronim><![CDATA[CortProteG]]></acronim><duration>20.12.2024 - 19.12.2027</duration><status>U tijeku</status><financ_value>200.000,00 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>2567, 26092, 22600, 25418, 23892, 865159, 26275, 865647, 19043, 868477, 13017, 868524, 869818, </team_members_id><team_members_names><![CDATA[Zdravko Petanjek, Ivan Banovac, Mihaela Bobić Rasonja, Sara Trnski, Marija Milković Periša, Matea Drlje, Davor Petrović, Matija Vid Prkačin, Katarina Ilic, Maja Horvat Božić, Božica Popović, Mirna Ivandić Lončar, Ivona Kirchbaum, ]]></team_members_names><keywords_hr><![CDATA[perinerunske mreže, moždana kora, brevican, neurorazvojni poremećaji, hipoksija]]></keywords_hr><keywords_en><![CDATA[perineuronal net, cerebral cortex, brevican, neurodevelopmental disorders, hypoxia]]></keywords_en><summary_hr><![CDATA[Poremećaji kortikogeneze kod ljudi rezultiraju neurorazvojnim kognitivnim ili neurološkim bolestima kao što su autizam, shizofrenija ili epilepsije. Složeni  proteoglikani (PG) su značajan dio kortikogeneze, osiguravaju fizičku potporu morfogenetskim i diferencijacijskim procesima i prostorno-vremensku organizaciju signalnih molekula. Prijašnjim projektom pokazali smo da je specifični difuzni raspored PG-a kritičan za praćenje razvoja fetalnog mozga čovjeka MR, zbog svojeg doprinosa obrascima i intenzitetu signala, a da su u zrelom korteksu PG kondenzirani u perineuronske mreže raspoređene oko određenih neuronskih populacija, koje pak nakon perinatalne hipoksije, u mozgu odrasla štakora bivaju značajno i trajno promijenjene što rezultira poremećajima u ponašanju štakora. Cilj ovog projekta je istražiti tranzicijsku molekularnu, prostornu i vremensku organizaciju PG u ranjivom perinatalnom razvoju moždane kore, otkrivanjem razlika u ekspresiji PG-a po kortikalnim slojevima i neuronskim populacijama i omogućiti uvid u ulogu PG-a u genezu quadripartitne sinapse, diferencijaciji i specifikaciji neuronskih krugova, a time uvid u razvoj konektoma, i sekundarnih vijuga i brazdi. Koristit ćemo molekularne (rtPCR, transkriptom), histološke (histokemija, imunohistokemija i RNAscope), kvalitativne i kvantitativne morfometrijske metode na post mortem ljudskom i životinjskom moždanom tkivu (model perinatalne hipoksije) te na organoidima ljudskog mozga. Rezultat projekta bit će razumijevanje sastava i uloge PG-a u perinatalnom sazrijevanju moždane kore, kao preduvjet za odabir ciljnih PG-a za funkcionalna testiranja u razvoju terapijskih i dijagnostičkih pristupa. Projekt će osigurati kvalitetne publikacije, jačanje međunarodne suradnje i zajedničkih projektnih prijedloga te razvoj mladih istraživača u području istraživanja neurorazvojnih poremećaja čovjeka. ]]></summary_hr><summary_en><![CDATA[Disorders of corticogenesis in humans result in neurodevelopmental cognitive or neurological diseases such as autism, schizophrenia, or epilepsy. Complex proteoglycans (PG) are essential to corticogenesis, providing physical support for morphogenetic processes and spatial-temporal organization of signaling molecules. In a previous project, we showed that the specific diffuse expression of PG is critical for monitoring the development of the human fetal brain by MR due to its contribution to the patterns and signal intensity. We also show that in the mature cortex, PG are condensed into perineuronal nets distributed around specific neuronal populations, which, after perinatal hypoxia, in the brains of adult rats, are significantly and permanently changed, and as a result, rats show behavioral aberration. This project aims to reveal the transitional molecular, spatial, and temporal organization of PG in the vulnerable perinatal cerebral cortex by identifying differences in the expression of PG by cortical layers and neuronal populations that enable an understanding of the role of PG in the genesis of the quadripartite synapse, differentiation, and specification of neuronal circuitries, and thus in the development of connectome, and secondary gyri and sulci. We will use molecular (rtPCR, transcriptome), histological (histochemistry, immunohistochemistry, RNAscope), qualitative and quantitative morphometric methods on postmortem human and animal brain tissue (perinatal hypoxia model) and brain organoids. The result of the project will be an insight into the composition and role of PGs in the perinatal maturation of the cerebral cortex as a prerequisite for selecting target PG for functional testing in the development of therapeutic and diagnostic approaches. The project will ensure quality publications, strengthen international cooperation and joint project proposals, and develop young researchers in the field of human neurodevelopmental disorders.]]></summary_en></project><project>
<id>16702</id><title_hr><![CDATA[Translacijska platforma za poboljšano predviđanje patogenosti varijanti OPTN gena u amiotrofičnoj lateralnoj sklerozi i srodnim neurodegenerativnim bolestima]]></title_hr><title_en><![CDATA[Translational platform for improved pathogenicity prediction of OPTN variants in amyotrophic lateral sclerosis and related neurodegenerative diseases]]></title_en><user_id>4630</user_id><user_firstLast_name>Ivana Munitic</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2024-05</proposal_call><code>IP-2024-05-5814</code><acronim><![CDATA[TranslateOPTNvar2NDD]]></acronim><duration>16.12.2024 - 15.12.2027</duration><status>U tijeku</status><financ_value>199.999,99 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, Clinical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Fakultet biotehnologije i razvoja lijekova]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Biotechnology and Drug Development]]></institution_en><team_members_id>26105, 861732, 868160, 12500, 868254, 868337, 868338, 868151, 20580, 868465, 868485, 29034, 868860, 872888, </team_members_id><team_members_names><![CDATA[Olga Shevchuk, Josip Peradinović, Fabiola De Marchi, Andrea Markovinović, Letizia Mazzini, Robert Russell, Gordana Apic, Toni Franjkić, Emanuele Buratti, Boris Rogelj, David Brenner, Željka    Minić , Jason R. Cannon, Ema Jalšić, ]]></team_members_names><keywords_hr><![CDATA[optineurin, neurodegeneracija, neuroinflamacija, imunodeficijencija, proteinopatija]]></keywords_hr><keywords_en><![CDATA[optineurin, neurodegeneration, neuroinflammation, immunodeficiency, proteinopathy]]></keywords_en><summary_hr><![CDATA[Terapije amiotrofične lateralne skleroze (ALS), frontotemporalne demencije (FTD) i srodnih neurodegenerativnih bolesti (NDD) važan su medicinski izazov. Genetski oblici ALS-a i FTD-a uzrokovani su mutacijama u više od 50 gena. ALS/FTD gen OPTN povezuje ključne značajke NDD-a, neuroupalu i proteinopatiju, predstavljajući potencijalni terapeutski cilj. Međutim, samo za nekolicinu OPTN mutacija potvrđeno je da uzrokuju NDD, a trenutni programi za predviđanja patogenosti za varijante nepoznatog značaja (VUS) su neprecizni. Štoviše, trenutna istraživanja na mišjim i staničnim OPTN modelima, slično modelima partnerske TBK1 kinaze, nisu adresirala sve funkcije optineurina i TBK1, posebno one  vezane uz imunosni sustav. Ovdje predlažemo poboljšati translacijski učinak istraživanja OPTN gena povezivanjem: 1) analiza proteinskih interakcija i procesa na koje utječu varijante OPTN gena, 2) računalnih strukturnih analiza za poboljšanje predviđanja patogenosti VUS-a i pronalazak terapijskih ciljeva, 3) validacija u organotipskim rezovima mozga, stanicama diferenciranim iz monocita zdravih ispitanika (+/-utišavanje OPTN-a) i OPTN pacijenata. U tu ćemo svrhu mapirati interaktom divljeg i mutiranog OPTN-a (povezanog s ALS/FTD i glaukomom) u HMC3 ljudskoj mikrogliji i SH-SY5Y neuronskim linijama. Ex vivo relevantnost mapiranih putova testirat će se u funkcionalnim testovima u organotipskim kortikalnim rezovima mozga napravljenim iz palete naših originalnih OPTN mišjih modela, a potom i u ljudskim uzorcima. Također ćemo generirati prediktivni program za VUS OPTN-a baziran na analizi proteinske strukture i proteinskih interakcija iz postojećih i novogeneriranih proteomskih i funkcionalnih analiza. Zaključno, predlažemo uspostaviti dvosmjernu platformu za proširenje razumijevanja OPTN varijanti i terapijskih ciljeva u NDD.]]></summary_hr><summary_en><![CDATA[Therapies in amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD) and related neurodegenerative diseases (NDD) remain a major unmet medical need. Genetic forms of ALS and FTD are caused by mutations in 50+ genes. ALS/FTD-linked gene OPTN links key NDD features, neuroinflammation and proteinopathy, presenting a potential therapeutic target. However, only a handful of OPTN mutations clearly segregate with individual NDDs, and current pathogenicity prediction programs for variants of unknown significance (VUS) are imprecise and thus incapable to guide clinical decisions. Moreover, the current OPTN mouse and cellular models, similar to ALS-models based on its partner TBK1 kinase, yet have to address the full spectrum of functions affected by the patient mutations, especially those relating to the immune system. Here we propose to improve translational impact of research on OPTN by connecting: 1) analysis of protein:protein interactions and pathobiological processes affected by OPTN variants, 2) computational structural analysis to improve VUS pathogenicity prediction, prioritize research and map therapeutic targets, 3) validation in organotypic brain slices, monocyte-derived cells from healthy subjects (+/-OPTN silencing) and OPTN patients. To this end, we will map the interactome of wild type and mutated OPTN (ALS/FTD- and glaucoma-linked) in HMC3 human microglia and SH-SY5Y neuronal lines by proximity labelling proteomics. Ex vivo relevance of mapped pathways will be tested in functional assays in organotypic cortical brain slices from a palette of our original OPTN mouse models and subsequently in human samples.  We will also generate a predictive program for OPTN VUS by analysing protein structure and protein interactions from existing and newly generated proteomic and functional analyses. Overall, we propose to assemble a two-way translational platform for expanding the mechanistic understanding of OPTN variants and NDD therapeutic targets. ]]></summary_en></project><project>
<id>16714</id><title_hr><![CDATA[Popravak križnih veza topoizomeraza i DNA in vivo koristeći model zebrice ]]></title_hr><title_en><![CDATA[The repair of topoisomerase DNA-protein crosslinks in vivo using zebrafish model]]></title_en><user_id>4272</user_id><user_firstLast_name>Marta Popović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2024-05</proposal_call><code>IP-2024-05-9425</code><acronim><![CDATA[TOPCROSS]]></acronim><duration>09.12.2024 - 08.12.2027</duration><status>U tijeku</status><financ_value>199.996,50 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>865219, 29045, 873005, 12354, 24303, </team_members_id><team_members_names><![CDATA[Marin Kutnjak, Cecile Otten, Leona Verasto, Marina Horvatiček, Marija Pranjić, ]]></team_members_names><keywords_hr><![CDATA[DNA oštećenja i popravak, križne veze DNA i proteina, topoizomeraza 1 i 2, zebrica, tirozil-DNA fosfodiesteraza 1 i 2, CRISPR]]></keywords_hr><keywords_en><![CDATA[DNA damage and repair, DNA-protein crosslinks, topoisomerase 1 and 2, zebrafish, tyrosyl-DNA phosphodiesterase 1 i 2, CRISPR]]></keywords_en><summary_hr><![CDATA[Križne veze DNA i proteina (DNA-protein crosslink, DPC) su česta oštećenja DNA koja nastaju ireverzibilnim kovalentnim vezanjem proteina i DNA. Ove glomazne lezije ometaju sve DNA transakcije, pa su stoga posljedice poremećenog popravka DPC oštećenja vrlo ozbiljne. Na staničnoj razini, neispravni popravak uzrokuje lomove DNA, genomsku nestabilnost i staničnu smrt, dok je na razini organizma poremećeni DPC popravak povezan s rakom, starenjem i neurodegeneracijom. Topoizomeraze (TOP) su među najzastupljenijim DPC oštećenjima u stanicama u fiziološkim uvjetima, a induceri TOP-DPC oštećenja kao što su topotekan i etopozid koriste se za liječenje raznih vrsta raka. Tirozil-DNA fosfodiesteraze (TDPs) su enzimi koji uklanjaju umrežene peptidne ostatke topoizomeraze iz DNA, a njihov nedostatak uzrokuje neurološke probleme kod miševa i ljudi. Unatoč mnogim naporima, popravak ovih visoko toksičnih oštećenja DNA još uvijek nije u potpunosti shvaćen. Istražit ćemo (1) koji su proteini ključni za popravak TOP1- i TOP2-DPC in vivo i jesu li epistatični, (2) vezu između TOP-DPC popravka i neuroloških defekata u organizmu s manjkom TDP-a, i (3) akumuliraju li se TOP-DPC u organizmu koji stari. Naš pristup uključuje: (a) utišavanje gena čimbenika popravka TOP-DPC oštećenja: sprtn, acrc, zatt, tex264, apex1, 2 i mre11 i inhibiciju ATPaze p97 i proteasoma u embrijima zebrica divljeg tipa i s nedostatkom Tdp enzima, (b) stvaranje tdp1 i tdp2 dvostrukih mutantnih sojeva zebrica, (c) karakterizaciju DPC profila u različitim pozadinama genske manipulacije u embrijima i različitim tkivima tijekom starenja, i (d) identifikaciju neuroloških promjena uključujući ataksiju, anksioznost, učenje i pamćenje kod odraslih riba s nedostatkom Tdp1 i Tdp2. Predloženi projekt bit će prvi koji će istraživati TOP-DPC popravak na razini organizma. To će poboljšati naše razumijevanje ljudskih bolesti i starenja i moglo bi dovesti do identifikacije novih lijekova za liječenje raka i neuroloških bolesti.]]></summary_hr><summary_en><![CDATA[DNA-protein crosslinks (DPCs) are frequent DNA lesions caused by irreversible covalent bonds between proteins and DNA. These bulky lesions hinder all DNA transactions, and therefore the consequences of impaired DNA-Protein Crosslink Repair (DPCR) are severe. At the cellular level, defective repair causes DNA breaks, genomic instability, and cell death, while at the organismal level, impaired DPCR is associated with cancer, aging, and neurodegeneration. Topoisomerases (TOPs) are among the most abundant DPCs in cells under physiological conditions and TOP-DPC inducers such as topotecan and etoposide are used to treat various cancers. Tyrosyl-DNA phosphodiesterases (TDPs) are enzymes that remove crosslinked topoisomerase peptide residues from the DNA and their deficiency leads to neurological defects in mice and humans. Despite many efforts, the repair of these highly toxic DNA lesions is still not fully understood. We will investigate (1) which proteins are crucial for the repair of TOP1- and TOP2-DPCs in vivo and whether they are epistatic, (2) link between TOP-DPCR and the neurological defects in TDP-deficient organism, and (3) whether TOP-DPCs accumulate in the aging organism. Our approach includes: (a) gene silencing of TOP-DPC repair factors: sprtn, acrc, zatt, tex264 apex1, 2 and mre11 and inhibition of ATPase p97 and proteasome in WT and Tdp-deficient zebrafish embryos, (b) generation of tdp1 and tdp2 double mutant zebrafish strains, (c) characterization of DPC profiles in different backgrounds of gene manipulation in embryos and in different tissues during aging, and (d) identification of neurological changes including ataxia, anxiety, learning and memory in Tdp1- and Tdp2-deficient adult fish. The proposed project will be the first to investigate TOP-DPC repair at the organismal level. It will improve our understanding of human disease and aging and could lead to the identification of new drug targets for the treatment of cancer and neurological diseases.   ]]></summary_en></project><project>
<id>16715</id><title_hr><![CDATA[Inovativni pristupi za smanjenje nusproizvoda dezinfekcije voda - nove tehnologije za nove izazove]]></title_hr><title_en><![CDATA[Innovative approaches for water disinfection byproducts mitigation - new technologies for new challenges]]></title_en><user_id>20206</user_id><user_firstLast_name>Krešimir Košutić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2024-05</proposal_call><code>IP-2024-05-7383</code><acronim><![CDATA[InWatTechno]]></acronim><duration>09.12.2024 - 10.12.2027</duration><status>U tijeku</status><financ_value>199.937,47 eur</financ_value><scie_area_hr>Tehničke znanosti, Prirodne znanosti, </scie_area_hr><scie_area_en>Technological sciences, Natural sciences, </scie_area_en><scie_field_hr>Interdisciplinarne tehničke znanosti, Kemija, Kemijsko inženjerstvo, </scie_field_hr><scie_field_en>Interdisciplinary technological sciences, Chemistry, Chemical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet kemijskog inženjerstva i tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Chemical Engineering and Technology]]></institution_en><team_members_id>29635, 12861, 1414, 707, 900, 23212, 868037, 868126, 872904, </team_members_id><team_members_names><![CDATA[Silvia Morović, Davor Ljubas, Sandra Babić, Hrvoje Juretić, Lidija Ćurković, Ivana Gabelica, Katarina Marija Drmić, Debora Briševac, Ena Miletić, ]]></team_members_names><keywords_hr><![CDATA[pitke vode, bazenske vode, dezinfekcijski nusproizvodi vode, membranski procesi, napredni oksidacijski procesi]]></keywords_hr><keywords_en><![CDATA[potable water, pool water, disinfection byproducts, membrane processes, advanced oxidation processes]]></keywords_en><summary_hr><![CDATA[InWatTechno projekt na inovativan način povezuje napredne membranske i oksidacijske postupke uklanjanja i razgradnje nusproizvoda dezinfekcije vode (DNP-a) i njihovih prekursora iz pitkih i bazenskih voda. Ciljani spojevi koji će se istraživati u ovom projektu su trihalometani (THM), halooctene kiseline (HAA) i nitrozamini (NA), od kojih je većina obuhvaćena europskim pa tako i hrvatskim propisima. Svi oni predstavljaju potencijalni rizik za zdravlje ljudi i vodni sustav. Povezivanje membranskih, posebno NF/RO procesa, s naprednim oksidacijskim procesima (AOP) kao što su O3/UV, H2O2/UV, O3/H2O2, UV/TiO2 i dr., predstavlja novije istraživačke trendove u obradi voda i njezine intenzifikacije s ciljem maksimalnog uklanjanja organskih mikroonečišćivala sintetskog porijekla (ksenobiotika) te DNP-a koji nastaju klasičnim postupcima dezinfekcije vode klorom i kloru sličnim dezinfekcijskim sredstvima. Projekt se bavi izazovom osiguravanja što kvalitetnije pitke vode te uvođenja novih tehnoloških postupaka obrade voda specifičnih kategorija. Nove spoznaje praktično će se primijeniti u obradi (kondicioniranju) voda u funkciji poboljšanja kvalitete vode za piće i rekreaciju, tj. zaštite zdravlja ljudi. Utjecaj rezultata na okoliš, tj. zaštitu vodnih resursa bit će vidljiv preko (a) smanjenja količine DNP-a u pitkim i bazenskim vodama koje nakon uporabe završavaju u okolišu kao otpadna voda i (b) smanjenja količine DNP-a u retentatu na izlazu iz membranskih procesa koji se također ispušta kao otpadna voda. Na taj način će se osigurati i zadovoljiti zakonska regulativa.]]></summary_hr><summary_en><![CDATA[The InWatTechno project innovatively combines advanced membrane and oxidation processes for removal and degradation of disinfection byproducts (DBPs) and their precursors (xenobiotics) from drinking and pool waters. The target compounds that will be investigated in this project are trihalomethanes (THM), haloacetic acids (HAA), and nitrosamines (NA), most of which are covered by European and Croatian regulations. All of them pose a potential risk to human health and the water system.Coupling advanced membrane, especially nanofiltration/reverse osmosis (NF/RO) processes, with advanced oxidation processes (AOP) such as O3/UV, H2O2/UV, O3/H2O2, UV/TiO2, etc., represents recent research trends in water treatment and its intensification with the aim of maximum removal of organic micropollutants of synthetic origin (xenobiotics), and DBPs that are produced by classic water disinfection procedures with chlorine and chlorine-like disinfectants. InWatTechno project deals with the challenge of ensuring high-quality drinking water and introducing new technological procedures for water treatment of specific categories. The new knowledge will be practically applied in the treatment (conditioning) of water in order to improve the quality of potable and pool water, i.e. the protection of human health. The impact of the results on the environment, i.e. the protection of water resources, will be visible through (a) a reduction in the amount of DBPs in drinking and swimming pool waters that end up in the environment as wastewater after use and (b) a reduction in the amount of DBPs in the retentate at the exit from of membrane unit, which is also discharged as wastewater. In this way, compliance with the legal regulations will be ensured.]]></summary_en></project><project>
<id>16718</id><title_hr><![CDATA[Antimikrobni peptidi temeljeni na prirodnim morskim antimikrobicima: Dizajn i studija načina djelovanja]]></title_hr><title_en><![CDATA[Antimicrobial peptides based on natural marine antimicrobials: Design and study of their mode of action]]></title_en><user_id>12635</user_id><user_firstLast_name>Andreja  Jakas</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2024-05</proposal_call><code>IP-2024-05-1216</code><acronim><![CDATA[AMPNatMarAM]]></acronim><duration>16.12.2024 - 15.12.2027</duration><status>U tijeku</status><financ_value>194.695,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, Interdisciplinarne prirodne znanosti, </scie_field_hr><scie_field_en>Chemistry, Interdisciplinary natural sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>19901, 184, 867996, </team_members_id><team_members_names><![CDATA[Marin Roje, Darko Kontrec, Nermina Malanovic, ]]></team_members_names><keywords_hr><![CDATA[žarnjaci, aurelin, ekvinin, peptidi, antimikrobno djelovanje]]></keywords_hr><keywords_en><![CDATA[cnidarians, aurelin, equinin, peptides, antimicrobial activity]]></keywords_en><summary_hr><![CDATA[Antimikrobni peptidi (AMP), bilo sintetski bilo prirodni, pobudili su veliki interes šire javnosti budući da su se pojavili patogeni bakterijski sojevi otporni na konvencionalne antibiotike. U tom kontekstu, naš projekt ima za cilj sintezu peptida na čvrstoj fazi, koji su kraći fragmenti prirodnih antimikrobnih peptida sa najmanjom jedinicom koja zadržava AM svojstva. Cilj nam je sintetizirati visoko vrijedne antimikrobne tvari temeljene na prirodnim peptidima izoliranim iz morskih organizama. Kao polazna osnova služi nam aurelin AMP izoliran iz žarnjaka Aurelia aurita s antibakterijskim djelovanjem na Gram-pozitivne (Listeria monocitogenes) i Gram-negativne (E. coli) bakterije. Želimo ispitati prirodu i razjasniti točne mehanizme antibakterijskog djelovanja. Jedan od naših ciljeva/targets bit će MurNAc pentapeptid translokaza I (MraY), enzim esencijalan za preživljavanje bakterija. Dizajnirat ćemo peptidne strukture s različitim jedinicama, dokazanog antimikrobnog djelovanja. Odredit ćemo aktivnost tih molekulskih struktura i njihov način djelovanja. Temeljna inovacija našega projekta je jedinstven put prema stvaranju kombinacija poželjnih antimikrobnih svojstava koristeći peptidne strukture nastale kombinacijom prirodih AMP i sintetskom nadogradnjom.]]></summary_hr><summary_en><![CDATA[Antimicrobial peptides (AMPs), whether synthetic or natural, have attracted considerable public interest since the emergence of pathogenic bacterial strains that are resistant to conventional antibiotics. In this context, our project aims at the synthesis of solid phase peptides, which are shorter fragments of natural antimicrobial peptides with the smallest unit that retains AM properties. Our goal is to synthesize highly effective antimicrobial substances based on natural peptides isolated from marine organisms. Our starting point is the aurelin AMP isolated from the cnidarian Aurelia aurita with antibacterial activity against Gram-positive (Listeria monocytogenes) and Gram-negative (E. coli) bacteria. We want to investigate and clarify the nature and exact mechanisms of the antibacterial action. One of our targets will be MurNAc pentapeptide translocase I (MraY), an enzyme that is essential for bacterial survival. We will design peptide structures with different moieties that have been shown to have antimicrobial activity. We will determine the activity of these molecular structures and their mode of action. The fundamental innovation of our project is a unique way to create combinations of desirable antimicrobial properties using peptide structures formed by the combination of natural AMPs and synthetic enhancements.]]></summary_en></project><project>
<id>16723</id><title_hr><![CDATA[Uloga plastičnosti i robusnosti u evolucijskim mehanizmima razvoja oka špiljske tetre Astyanax mexicanus]]></title_hr><title_en><![CDATA[Exploring plasticity and robustness: Unravelling evolutionary mechanisms of eye development in cave tetra, Astyanax mexicanus]]></title_en><user_id>1207</user_id><user_firstLast_name>Helena Bilandžija</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2024-05</proposal_call><code>IP-2024-05-2868</code><acronim><![CDATA[EvoEye]]></acronim><duration>20.12.2024 - 19.12.2027</duration><status>U tijeku</status><financ_value>199.987,50 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>867870, 865938, 19415, 867843, 868562, 872841, </team_members_id><team_members_names><![CDATA[Juan Tena, Marko Lukić, Romana Gračan, Jaya Krishnan, Lucija Kauf, Laura Guerrero, ]]></team_members_names><keywords_hr><![CDATA[špiljske životinje, kolonizacija podzemlja, degeneracija očiju, maladaptivna fenotipska plastičnost, robustnost]]></keywords_hr><keywords_en><![CDATA[cave animals, cave colonization, eye degeneration, maladaptive phenotypic plasticity, robustness]]></keywords_en><summary_hr><![CDATA[Hipoteza plastičnost-prva nudi objašnjenje za brzu evoluciju konvergentnih svojstava. Prema njoj, prilagodba novom okolišu počinje plastičnim izmjenama fenotipskih svojstava koje se genetički asimiliraju, prespajanjem postojećih razvojnih i homeostatskih molekularnih mreža. Kako inicijalna plastičnost, osobito maladaptivna, utječe na fenotip i njegovu promjenu tijekom evolucije je pitanje koje ćemo istražiti na ribi meksičkoj špiljskoj tetri, Astyanax mexicanus. Ova vrsta obuhvaća površinske ribe koje predstavljaju pretke koji su neovisno kolonizirali špilje i evoluirali u špiljske ribe. Špiljske ribe pokazuju specifične osobine poput gubitka očiju i pigmenata, hipertrofiju ne-vizualnih senzornih sustava i metaboličke promjene, koje su se razvile u iznimno kratkom evolucijskom periodu. U prethodnoj studiji otkrili smo da je izlaganje površinske ribe konstantnom mraku dovelo do pojave osobina špiljske ribe već unutar jedne generacije, dok su fenotipovi špiljske ribe robusni na okolišne promjene. Iznenađujuće, plastični odgovor u očima površinskih populacija A. mexicanus izloženih tami, ali i kod špiljske populacije filogenetski udaljene ribe Telestes karsticus, uključivao je proliferaciju u mrežnici. Ovo otkriće sugerira da konvergentni procesi kontroliraju razvoj oka kod površinskih riba izloženih mraku, i da degeneracija očiju kod špiljske ribe uključuje kompenzacijske procese za prevladavanje i preokret ove početne maladaptivne plastičnosti. Cilj ovoga projekta je istražiti značajke oka kod A. mexicanus površinskih riba, površinskih riba izloženih tami kroz više generacija i evoluiranih špiljskih riba, kako bismo razumjeli razvojne, stanične, molekularne i epigenetske procese koji pokreću plastičnost, kompenzacijske mehanizme protiv maladaptivne plastičnosti i pojavu robusnosti u špiljskih riba. Naši rezultati će rasvijetliti mehanizme rapidne evolucije i konvergencije, kako bismo stekli uvid u fundamentalne procese koji pokreću fenotipsku raznolikost u prirodi.]]></summary_hr><summary_en><![CDATA[The plasticity-first hypothesis offers an explanation for the rapid evolution of convergent traits. It suggests that adaptation to new environments relies on the plastic appearance of phenotypic traits that become genetically assimilated through the rewiring of existing developmental and homeostatic networks. However, how the initial plastic responses, especially maladaptive, influence derived phenotypes over evolutionary time remains elusive. Here, we will use the Mexican tetra, Astyanax mexicanus, as a model system to address this question. This species is comprised of ancestral surface fish that independently colonized caves and evolved into cavefish. Cavefish exhibit novel traits, such as eye loss, depigmentation, sensory system expansions, and metabolic changes, which evolved within a remarkably short evolutionary timespan. Our previous study revealed that surface fish raised in complete darkness express many cavefish-like traits within a single generation, while cavefish traits are robust to environmental perturbation. Surprisingly, the eyes of dark-reared Astyanax surface fish and also in a cave population of the unrelated fish Telestes karsticus showed a maladaptive plastic response: increased thickness of the retinal layers. This suggests that convergent mechanisms underlie eye development in surface fish exposed to darkness and that eye degeneration in cavefish involves compensatory processes to overcome and reverse this initial maladaptive plasticity. We aim to investigate eye traits in ancestral Astyanax surface fish, multiple generations of dark-raised surface fish, and evolved cavefish, to understand the developmental, cellular, molecular, and epigenetic processes driving plasticity, compensatory mechanisms against maladaptive plasticity, and the transition to trait robustness in cavefish. Our findings will illuminate the mechanisms of rapid evolution and convergence, shedding new light on fundamental processes driving phenotypic diversity in nature.]]></summary_en></project><project>
<id>16732</id><title_hr><![CDATA[Uspješno seksualno starenje – prospektivna dijadička studija mješovite metodologije]]></title_hr><title_en><![CDATA[Successful Sexual Aging – A Longitudinal Mixed Method Dyadic Study]]></title_en><user_id>5817</user_id><user_firstLast_name>Aleksandar Štulhofer</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2024-05</proposal_call><code>IP-2024-05-5159</code><acronim><![CDATA[HEALTHSEXAGE]]></acronim><duration>20.12.2024 - 19.12.2027</duration><status>U tijeku</status><financ_value>162.750,00 eur</financ_value><scie_area_hr>Društvene znanosti, Biomedicina i zdravstvo, </scie_area_hr><scie_area_en>Social sciences, Biomedicine and health sciences, </scie_area_en><scie_field_hr>Sociologija, Javno zdravstvo i zdravstvena zaštita, Psihologija, </scie_field_hr><scie_field_en>Sociology, Public health and health services, Psychology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>5502, 17799, 867773, 409, 1087, 867772, 19564, 867780, 865722, 872971, </team_members_id><team_members_names><![CDATA[Ivan Landripet, Goran Koletić, Sharron Hinchliff, Branko Kolarić, Azra Tafro, Jasmina Mehulić, Tanja Jurin, Thomas Hansen, Tanja Bukovčan, Danijela Vlahov, ]]></team_members_names><keywords_hr><![CDATA[stariji parovi, uspješno seksualno starenje, seksualno zdravlje, dijadna mješovitometodološka studija, prospektivna procjene]]></keywords_hr><keywords_en><![CDATA[aging couples, successful sexual aging, sexual health, dyadic mixed method study, prospective assessment]]></keywords_en><summary_hr><![CDATA[Sve veći broj ljudi diljem zapadnog svijeta živi do duboke starosti te pridaje sve veću važnost seksualnom zdravlju. Međutim, postojeća znanstvena literatura o seksualnosti i starenju ograničena je: (a) nedostatkom konceptualne jasnoće o seksualnoj dobrobiti starijih osoba; (b) odsutnošću dijadnih analiza; (c) nepostojanjem prospektivnih istraživanja; i (d) nedostatkom primjene mješovite metodologije u istraživanju procesa seksualnog starenja. Naš interdisciplinarni istraživački projekt ima za cilj osloviti te nedostatke primjenom novog konceptualnog modela – uspješnog seksualnog starenja (SSA) – koji se temelji na modelima uspješnog starenja (Rowe i Kahn) i selektivne optimizacije s kompenzacijom. Kako bismo pružili razumijevanje temeljeno na dokazima o procesima koji leže u osnovi SSA i čimbenicima koji ga mogu spriječiti, koristimo robusnu metodologiju – longitudinalnu dijadnu procjenu i analitički pristup mješovite metodologije. Projekt će koristiti kvantitativne i kvalitativne podatke za: (1) istraživanje ključnih elemenata SSA; (2) opisivanje promjene u SSA i njegovih korelate; (3) procjenu uloge društvene povezanosti; (4) detektiranje moguće rodne specifičnosti SSA; i (5) utvrđivanje uloge osobne i seksualne povijesti para u dinamici SSA. Kvalitativni dio će uključivati 35-50 intervjua sa starijim parovima u drugoj projektnoj godini. Te će dijade biti podskup longitudinalnog panela (350-400 parova) koji će se ispitivati u tri navrata, u razmaku od 12 mjeseci (kvantitativni dio studije). Primijenit će se internetsko anketiranje koje je uspješno pilotirano 2020. godine. Predloženi istraživački projekt pružit će jedinstven doprinos literaturi o seksualnom starenju. Očekuje se da će njegovi konceptualni i empirijski uvidi unaprijediti razumijevanje starenja i seksualnosti, informirati stručnjake za društvenu gerontologiju i seksualno zdravlje te usmjeriti seksualno obrazovanje odraslih, intervencije u seksualnom zdravlju i savjetovanje starijih parova.]]></summary_hr><summary_en><![CDATA[An increasing number of people across the Western world are living into old age and placing a higher value on sexual health than previous generations. The existing literature on sexuality and aging, however, is limited by: (a) a lack of conceptual clarity about sexual well-being in older adults; (b) absence of dyadic assessments; (c) absence of prospective explorations; and (d) paucity of mixed method approaches to the process of sexual aging. Our interdisciplinary research project aims to fill these knowledge gaps by introducing a novel conceptual model – successful sexual aging (SSA) – that builds on the Successful Aging and Selective Optimization with Compensation models. To provide evidence-based understanding of the processes underlying SSA and factors that may impede it, we use robust methodology – longitudinal dyadic assessment and a mixed method analytical approach. The project will use quantitative and qualitative data to: (1) explore core elements of successful sexual aging (SSA); (2) describe changes in SSA and its correlates; (3) assess the role of social connectedness; (4) address possible gender-specificity of SSA; and (5) establish a role of personal and couple sexual history in the dynamics of SSA. The qualitative arm will entail 35-50 interviews with older couples in the second project year. These dyads will be a subset of a longitudinal panel (350-400 couples) that will be surveyed on three occasions, roughly 12 months apart (the quantitative study arm). Online surveying, which was successfully piloted in 2020, will be applied. The proposed research project will provide a unique contribution to the literature on sexual aging. Its conceptual and empirical insights are expected to advance the understanding of aging and sexuality, inform social gerontology and sexual health experts, and guide adults’ sexuality education, sexual health interventions, and counseling in older couples.]]></summary_en></project><project>
<id>16734</id><title_hr><![CDATA[Žene i mijene: žene kao subjekti povijesnih mijena u Hrvatskoj     ]]></title_hr><title_en><![CDATA[Women and Changes: Women as Subjects of Historical Changes in Croatia ]]></title_en><user_id>19116</user_id><user_firstLast_name>Ida Ograjšek Gorenjak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2024-05</proposal_call><code>IP-2024-05-3847</code><acronim><![CDATA[ŽiM/WaCh]]></acronim><duration>20.12.2024 - 19.12.2027</duration><status>U tijeku</status><financ_value>182.270,00 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Povijest, Interdisciplinarne humanističke znanosti, </scie_field_hr><scie_field_en>History, Interdisciplinary humanities, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>17872, 23254, 868030, 23270, 868040, 509, 26357, 23255, 868074, 7383, </team_members_id><team_members_names><![CDATA[Ana Batinić, Andrea Feldman, Maria Pakucs, Andrea Peto, Emily Greble, Zrinka Nikolić Jakus, Inga Vilogorac Brčić, Marijana Kardum, Mirjam Vida Blagojević, Luka Špoljarić, ]]></team_members_names><keywords_hr><![CDATA[ženska pov, hrvatska pov, medievistika, antika, rani novi vijek, moderna i suvremena pov, kulturna pov, društvena pov, intelektualna pov,]]></keywords_hr><keywords_en><![CDATA[women&#39;s his, Croatian his, medieval his, Antiquity, early modern his, modern and contemporary his, cultural his, social his, intellectual his]]></keywords_en><summary_hr><![CDATA[Cilj projekta je razviti znanstveni dijalog o povijesti žena u Hrvatskoj na dijakronijskoj razini. Okosnica dijaloga bili bi temeljni povijesni koncepti kao što su povijesni subjekt i povijesna mijena. Polazimo, dakle, od dviju ključnih pretpostavki povijesti žena: a) žene na prostoru Hrvatske treba istraživati kao povijesne subjekte, odnosno osobe koje su doprinosile, sudjelovale i doživljavale povijesne procese; b) povijesni procesi i povijesne mijene imali su izravan utjecaj na položaj žena i percepciju njihove uloge u društvu. Na tom tragu, istraživanja na projektu nastojat će odrediti koji su povijesni procesi otvarali, odnosno zatvarali mogućnosti djelovanja žena te definirati idejne i realne prostore u kojima su se žene mogle društveno aktivirati u različitim povijesnim razdobljima. Istražit će se kako su žene kroz intelektualno, socijalno i kulturno djelovanje utjecale na društvene procese, te odrediti utjecaj povijesnih mijena na status i identitet žena u pojedinim razdobljima. Napokon, cilj je napisati biografije angažiranih, ali još uvijek nedovoljno poznatih žena iz svakog pojedinog razdoblja u kojima ćemo istovremeno na konkretnim primjerima istražiti i ilustrirati gore navedene teze te žene napokon upisati u službenu povijest. Budući da projekt ima dijakronijski fokus, metodologija i izvori istraživanja bit će prilagođeni potrebama konkretnog povijesnog razdoblja. Teorijski, kombinirat će se pristup ženske, intelektualne, socijalne, kulturne povijesti i povijesti književnosti, a važan oslonac pružit će nam i rezultati projekta HRZZ-a &#39;&#39;Moderne misleće žene&#39;&#39;. Projekt će s jedne strane pridonijeti razvoju ženske povijesti u Hrvatskoj, potaknuti dijalog i komparaciju teorijskih pristupa i metodologije povijesti žena iz različitih povijesnih razdoblja i  produbiti spoznaje o ostalim povijesnim procesima pojedinih razdoblja. Napokon, dobiveni znanstveni rezultati lako će se moći koristiti i primijeniti u raznim projektima koji populariziraju znanost.]]></summary_hr><summary_en><![CDATA[The project aims to foster scientific dialogue on the history of women in Croatia across different historical periods, focusing on fundamental historical concepts such as the subject of history and historical change. It is grounded in two key theses of women&#39;s history: a) women in Croatia should be researched as historical subjects, contributing to, participating in, and experiencing historical processes; b) historical processes and changes directly impacted the position of women and perceptions of their role in society. Research within the project will aim to identify historical processes enabling or constraining women&#39;s agency and define the spaces where women could actively participate across different eras. It will explore how women influenced social processes through intellectual, social, and cultural activities, and assess the impact of historical changes on women&#39;s status and identity in various contexts. The ultimate goal is to compose biographies of active yet underrecognized women from each period, Through these biographies, we will seek to simultaneously explore and illustrate the aforementioned theses and finally inscribe these women into official history. Given the diachronic focus, the project&#39;s methodology and research sources will be tailored to the specific needs of each period, combining approaches from women&#39;s history, intellectual history, social history, cultural history, and literary history, and drawing support from the outcomes of the HRZZ project &#39;&#39;Modern Women Thinkers&#39;&#39;. Expected outcomes include advancements in women&#39;s history in Croatia facilitated by comparing theoretical approaches and methodologies across different historical periods, better understanding of historical processes within each period, and findings readily applicable in diverse projects promoting scientific knowledge. ]]></summary_en></project><project>
<id>16738</id><title_hr><![CDATA[Izloženost, biološki učinci i sudbina mikroplastike u akvatičkih organizama pod različitim antropogenim utjecajima]]></title_hr><title_en><![CDATA[Exposure, biological effects and fate of microplastics in aquatic organisms under different anthropogenic impacts]]></title_en><user_id>12330</user_id><user_firstLast_name>Vlatka Filipović Marijić</user_firstLast_name><svouser_id>868057</svouser_id><svouser_firstLast_name>Andreja Ramšak</svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2024-05</proposal_call><code>IP-2024-05-8918</code><acronim><![CDATA[PlastOrgAnoTox]]></acronim><duration>20.12.2024 - 19.12.2027</duration><status>U tijeku</status><financ_value>199.720,50 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Interdisciplinarne prirodne znanosti, Geologija, Kemija, Biologija, </scie_field_hr><scie_field_en>Interdisciplinary natural sciences, Geology, Chemistry, Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>21287, 11251, 5805, 865083, 220, 425, 5780, 856187, 868212, 868281, 869786, 873061, </team_members_id><team_members_names><![CDATA[Tatjana Mijošek, Dušica Ivanković, Damir Valić, Sara Šariri, Jasminka Kontrec, Branka Njegić Džakula, Kristina Pikelj, Kristina Bule Možar, Milen Nachev, Bernd Sures, Marija Kuštro, Davor Merkas, ]]></team_members_names><keywords_hr><![CDATA[Mikroplastika, zagađenje, akvatički organizmi, izloženost, biomarkeri, opasnost, procjena rizika]]></keywords_hr><keywords_en><![CDATA[Microplastics, pollution, aquatic organisms, exposure, biomarkers, hazard, risk assessment]]></keywords_en><summary_hr><![CDATA[Prisustvo mikroplastike (MP) u okolišu predstavlja globalni problem današnjice. Većina istraživanja usmjerena je na morske ekosustave, iako su i slatkovodni opterećeni unosom MP-a te predloženi projekt obuhvaća riječni sustav (Krka) i Jadransko more kod ušća Krke s ciljem procjene prisustva MP-a u vodi, sedimentu i akvatičkim organizmima (ribe i školjkaši) iz okoliša i uzgoja. Projektni ciljevi uključuju a) određivanje učinaka i bioloških promjena u divljih i eksperimentalnih organizama u ovisnosti o izloženosti MP-u i b) procjenu okolišnog rizika i izbor novih biomarkera izloženosti MP-u. Biološki učinci MP-a na organizme će se istraživati u područjima pod antropogenim utjecajima (otpadne vode, poljoprivreda, turizam, nautičke marine), kontrolnoj postaji (izvor rijeke Krke), te na uzgajalištima potočnih pastrva, orada i dagnji. Probavilo, škrge i mišići riba te probavna žlijezda, škrge i plašt dagnji predstavljat će ciljne organe. Uz divlje populacije, koje su pod utjecajem smjese zagađivala, eksperimentalni organizmi će se izložiti određenim vrstama, veličinama, koncentracijama i oblicima MP-a, individualno te u kombinaciji s različitim vrstama polimera i zagađivala (metali). Biološke promjene kao posljedica izlaganja MP-u (ribe i dagnje iz okoliša, dagnje iz pokusa) će obuhvaćati fiziološke promjene, genotoksičnost, neurotoksičnost i multibiomarkerski pristup. Sudbina MP-a u mekim tkivima te mogući mehanizam ugradnje u ljušturu analizirat će se u izloženim dagnjama, kao dobro poznatim sedentarnim organizmima. Akutna toksičnost MP-a procijenit će se u vodenbuha, predstavnika primarnih potrošača u slatkovodnim ekosustavima. Crijevni nametnici riba, kukaši, poslužit će kao novi model za procjenu mehanizma potencijalnog izlaganja i unosa MP-a u nametnike. Sveobuhvatni rezultati o utjecaju MP-a u realnim uvjetima okoliša, akvakulturi, pokusnim izlaganjima će dati inovativne podatke koji će omogućiti procjenu okolišnog rizika i izbor novih biomarkera izloženosti MP-u.]]></summary_hr><summary_en><![CDATA[The presence of microplastics (MP) in environment is considered a global problem. Most research is focused on marine ecosystems, although freshwaters are also burdened with MP, so the proposed project covers riverine system (Krka) and the Adriatic Sea at the mouth of the Krka River to assess MP occurrence in water, sediment and aquatic organisms (fish and mussels), considering wild and farmed populations. The project objectives are: (a) to assess relation of MP occurrence with effects and biological changes in wild and exposed aquatic organisms and (b) to identify environmental risks and discover novel biomarkers of MP exposure. Biological effects of MP on organisms will be studied in anthropogenically affected areas (wastewater, agriculture, tourism, nautical marinas), control site (river spring) and farming sites of brown trout, gilthead seabream and mussels. Intestine, gills and muscle in fish and digestive gland, gills and mantle in mussels represent target organs. In addition to wild populations, impacted by mixture of contaminants, organisms will be exposed to certain types, sizes, concentrations and shapes of MP and their combination with other polymer types and pollutants (metals). Measured biological changes upon exposure to MP (fish and mussels from environment, mussels from experiments) will include physiological changes, genotoxicity, neurotoxicity and multibiomarker approach. The fate of MP in soft tissues and possible mechanism of incorporation into the shell will be analysed in exposed mussels, a well-known sentinel organism. Acute toxicity of MP will be assessed in daphnids, representatives of primary consumers in freshwaters. Fish intestinal parasites, acanthocephalans, will serve as a new model for assessing mechanism of possible co-exposure and MP uptake in parasites. Comprehensive results on MP impact in environment, aquaculture, experimental exposures, will provide input data for environmental risk assessment and novel biomarkers of MP exposure.]]></summary_en></project><project>
<id>16740</id><title_hr><![CDATA[Fluidni i kvazi-fluidni međuprodukti u reakcijama u čvrstom stanju]]></title_hr><title_en><![CDATA[Fluid and quasi-fluid intermediates in solid-state reactions]]></title_en><user_id>329</user_id><user_firstLast_name>Nikola Biliškov</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2024-05</proposal_call><code>IP-2024-05-2450</code><acronim><![CDATA[GrindCore-2]]></acronim><duration>09.12.2024 - 08.12.2027</duration><status>U tijeku</status><financ_value>199.755,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>866284, 868044, 29530, 868102, 29669, 868105, 25668, 868108, 25267, </team_members_id><team_members_names><![CDATA[Vedrana Špada, Hatem Titi, Valentina Martinez, Igor Milanovic, Goran Zgrablić, Katarina Batalović, Tomislav Mrla, Andreas Borgschulte, Toni Grgurić, ]]></team_members_names><keywords_hr><![CDATA[čvrsto stanje, mehanokemija, međupovršine, eutektici, difuzija, spektroskopija, PXRD]]></keywords_hr><keywords_en><![CDATA[solid state, mechanochemistry, interfaces, eutectics, diffusion, spectroscopy, PXRD]]></keywords_en><summary_hr><![CDATA[Uzimajući u obzir temeljnu činjenicu da bilo koja kemijska reakcija iziskuje mobilnost molekula reaktanata kako bi se omogućili njihovi sudari, čini se da redovno opažene amorfne faze, koje nastaju u prvim fazama reakcija, igraju aktivnu ulogu. Te fluidne ili kvazi-fluidne faze djeluju kao medij što omogućuje mobilnost uključenih kemijskih vrsta, osiguravajući okruženje u kojem je kemijska reakcija moguća. S druge strane, jasno je da su u čvrstom stanju kemijske reakcije inicirane dodirom dviju tvari te se odvijaju na njihovoj dodirnoj površini. Ipak, taj fundamentalni aspekt do sada nije bio dovoljno detaljno obrađen. Prodor u mehanističke detalje tih procesa će u okviru ovog projekta biti omogućen izučavanjem makroskopski statičnih reakcija s dobro definiranim dodirnim površinama među reaktantima, te njihovim prostorno i vremenski razlučivim kemijskim mapiranjem. S druge strane, vremenski razlučivim praćenjem odabranih makroskopski dinamičkih reakcija u čvrstom stanju, dakle mehanokemijskih reakcija, dobit ćemo rezultate koji će omogućiti komparaciju kinetičkih i ostalih parametara koji određuju reaktivnost s onima dobivenima mapiranjem statičkih reakcija. To će biti omogućeno ekstenzivnim korištenjem korištenjem metoda difrakcije sinhrotronskog X-zračenja na prahu i mikrospektroskopijama. Smatramo da tim pristupom možemo kvalitativno i kvantitativno detektirati i karakterizirati evoluciju kemijskih vrsta uključenih u te fundamentalne procese. Na temelju tih spoznaja, obradit ćemo nekoliko važnih skupina reakcija u čvrstom stanju, koje postaju sve prisutnije u suvremenoj preparativnoj kemiji. Konkretno, obradit ćemo reakcije ubrzanog starenja, kokristalizacije iz molekulskih eutektičkih smjesa i tekućinama potpomognuto mljevenje. Na kraju ćemo sve to primijeniti na reakcije u čvrstom stanju, koje su relevantne za tehnološke, biomineralizacijske i geološke procese. Očekujemo da ćemo time dati doprinos temeljnom razumijevanju reaktivnosti u čvrstom stanju.]]></summary_hr><summary_en><![CDATA[Fundamental fact that any chemical reaction requires mobility of reactant molecules to allow their collisions, it seems that regularly observed amorphous phases play an active role at the first stages of solid-state reactions. These fluid or quasi-fluid intermediates act as a medium that enables mobility of involved chemical species, providing an environment in which a chemical reaction is possible. On the other hand, it is clear that solid-state chemical reactions are initiated by the contact of two substances and take place on the interface. However, this fundamental aspect has not been dealt with in sufficient detail so far. Within the framework of this project, penetration into the mechanistic details of these processes will be enabled by studying macroscopically static reactions on well-defined interfaces, and by their spatially and temporally resolved chemical mapping. On the other hand, time-resolved monitoring of selected macroscopically dynamic solid-state reactions, i.e. mechanochemical reactions, we will obtain results that will enable comparison of kinetic and other parameters that determine reactivity with those obtained by mapping static reactions. This will be made possible by extensive use of synchrotron X-ray powder diffraction and microspectroscopies. By this approach we will be able to qualitatively and quantitatively detect and characterize the evolution of chemical species involved in these fundamental processes. Based on these findings, we will discuss several important groups of reactions in the solid state, which are becoming more and more prevalent in modern preparative chemistry. In particular, we will investigate accelerated aging reactions, cocrystallizations from molecular eutectic mixtures and liquid-assisted grinding. Finally, we will apply all this to solid-state reactions relevant to technological, biomineralization and geological processes. ]]></summary_en></project><project>
<id>16742</id><title_hr><![CDATA[Ocean budućnosti: Hoće li promijenjeni sastav fitoplanktona pozitivno utjecati na biološku pumpu ugljika?]]></title_hr><title_en><![CDATA[The ocean of the future: Will changed phytoplankton composition positively impact the biological carbon pump?]]></title_en><user_id>81</user_id><user_firstLast_name>Blaženka Gašparović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2024-05</proposal_call><code>IP-2024-05-8589</code><acronim><![CDATA[FUTURE OCEAN]]></acronim><duration>16.12.2024 - 15.12.2027</duration><status>U tijeku</status><financ_value>199.709,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Interdisciplinarne prirodne znanosti, Kemija, Biologija, Interdisciplinarne prirodne znanosti, </scie_field_hr><scie_field_en>Interdisciplinary natural sciences, Chemistry, Biology, Interdisciplinary natural sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>451, 867755, 865609, 867840, 101, 865607, 4424, 2776, 872539, 869754, 873071, </team_members_id><team_members_names><![CDATA[Jelena Godrijan, Megumu Fujibayashi, Gabor Galiba, Huan Chen, Marina  Mlakar, Tamas Palmai, Daniela Maric, Tanja Vojvoda Zeljko, Martha Chacon-Patino, Robert Horn, Leonarda Lazarin, ]]></team_members_names><keywords_hr><![CDATA[Ocean budućnosti, biološka pumpa ugljika, organska tvar, lipidi, fotooksidacija, biodegradacija]]></keywords_hr><keywords_en><![CDATA[Future ocean, biological carbon pump, organic matter, lipids, photooxidation, biodegradation]]></keywords_en><summary_hr><![CDATA[Jedna od glavnih briga oceanologa je u kojoj će mjeri globalno zatopljenje i povezane promjene utjecati na sposobnost oceana da ublaže te utjecaje. „Biološka ugljikova pumpa“ (BCP), odnosno biološki vođeno izdvajanje ugljika (C) iz atmosfere i površine oceana na morsko dno jedan je od najvažnijih procesa koji pridonose ublažavanju klimatskih promjena. Proučavani su različiti parametri koji mogu utjecati na učinkovitost BCP-a. Razmjer do kojeg bi izmijenjeni sastav fitoplanktona bio podložan abiotičkoj (fotooksidacija) i biološkoj (fikosferske bakterije) razgradnji, nazvano bio/razgradnja, još nije proučavan niti razmatran u scenarijima klimatskih promjena. Predviđanja su da će klimatske promjene dovesti do manje proizvodnje dijatomeja, što će se kompenzirati kokolitoforidima. Obje skupine imaju potencijal potonuća zbog teških ljuski na površini stanice. Planiramo uzgajati dijatomeju i kokolitoforidu u optimalnim i nepovoljnim uvjetima koji oponašaju zagrijavanje i oligotrofiju. Kulture iz stacionarne faze rasta bile bi podvrgnute bio/razgradnji. Složenim metodološkim pristupom analizirat ćemo količinu i kvalitetu organske tvari (OT), posebice lipida, uključujući DOC, POC, SAS, CDOM, FDOM, zajedno s morfologijom stanice, pigmentima, sadržajem C, N i P te ekspresijom gena povezanih s lipidima. Kako bi se dopunili rezultati laboratorijskih pokusa, uzimat će se uzorci morske vode tijekom razdoblja cvatnje dijatomeja i kokolitoforida. Lipidi su zanimljivi jer se pokazalo da se selektivno čuvaju u dubokom moru. Naš će projekt dati uvid u to hoće li OT fitoplanktona, posebice lipidi, biti više ili manje razgradivi u budućem oceanu. Naše predviđanje je da će OT, posebno lipidi, kokolitofora biti stabilniji od onih dijatomeja. Naši rezultati pružit će dodatna znanja za predviđanje u kojoj će mjeri globalne promjene utjecati na BCP.]]></summary_hr><summary_en><![CDATA[One of the major concerns of marine scientists is the extent to which global warming and the associated changes will affect the ability of oceans to mitigate these impacts. The &#39;&#39;biological carbon pump&#39;&#39; (BCP), i.e., biologically driven C sequestration from the atmosphere and surface ocean to the seafloor is one of the most important processes contributing to the mitigation of climate change. A variety of parameters that may affect the effectiveness of the BCP have been studied. The extent to which altered phytoplankton composition would be subject to abiotic (photooxidation) and biological (phycosphere bacteria) degradation, termed bio/degradation, has not yet been studied or considered in climate change scenarios. The predictions are that climate change will lead to lower production of diatoms, which will be compensated for by coccolithophores. Both groups have the potential to sink due to the heavy shells on the cell surface. We plan to grow diatom and coccolithophore under optimal and unfavourable conditions mimicking warming and oligotrophy. Cultures from the stationary growth phase would be subjected to bio/degradation. Using a complex methodological approach, we will analyse the quantity and quality of organic matter (OM), especially lipids, including DOC, POC, SAS, CDOM, FDOM, together with cell morphology, pigments, C, N and P content and gene expression related to lipids. To supplement the results of the laboratory experiments, seawater samples will be taken during the diatom and coccolithophore bloom periods. Lipids are of interest because they are selectively preserved in the deep sea. Our project will provide insight into whether phytoplankton OM, particularly lipids, will be more or less degradable in the future ocean. Our prediction is that the OM, especially lipids, of coccolithophores will be more stable than those of diatoms. Our results will provide additional knowledge for predicting the extent to which global change will affect BCP.]]></summary_en></project><project>
<id>16745</id><title_hr><![CDATA[Bis-fosfini kao nemetalni katalizatori za aktivaciju malih molekula - dizajn i sinteza]]></title_hr><title_en><![CDATA[Bis-phosphines as Metal-Free Catalysts for Small Molecules&#39; Activation - Design and Synthesis]]></title_en><user_id>56</user_id><user_firstLast_name>Borislav Kovačević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2024-05</proposal_call><code>IP-2024-05-7730</code><acronim><![CDATA[CatDesSyn]]></acronim><duration>16.12.2024 - 15.12.2027</duration><status>U tijeku</status><financ_value>182.275,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, Interdisciplinarne prirodne znanosti, </scie_field_hr><scie_field_en>Chemistry, Interdisciplinary natural sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>3235, 3397, 368, 866028, 866041, 3775, 872899, 873052, </team_members_id><team_members_names><![CDATA[Danijela  Barić, Ines Despotović, Zoran Glasovac, Milena Mlakić, Joerg Sundermeyer, Irena Škorić, Karla Bulava, Mario Damjanović, ]]></team_members_names><keywords_hr><![CDATA[dizajn katalizatora, nemetalna kataliza, frustrirani Lewisovi parovi, hidričnost, redukcija CO2, aktivacija dušika i metana]]></keywords_hr><keywords_en><![CDATA[catalyst design, metal free catalysis, frustrated Lewis pairs,  hydricity, CO2 reduction, dinitrogen and methane activation]]></keywords_en><summary_hr><![CDATA[Kataliza igra važnu ulogu u gotovo svim granama kemije, stoga je dizajn učinkovitih katalizatora konstantan znanstveni izazov. U suvremenim znanstvenim istraživanjima vezanim uz dizajn katalizatora obično se koristi kombinacija eksperimentalnog i računalnog pristupa jer njihova međusobna sinergija pozitivno utječe na konačni rezultat. Aktivacija malih molekula odgovarajućim katalizatorom prvi je korak mnogih kemijskih transformacija povezanih sa sintezom novih spojeva i materijala. Tijekom posljednjih 60 godina, istraživanja u području organometalne kemije značajno su pridonijela području dizajna katalizatora, nudeći veliki broj visoko reaktivnih i selektivnih spojeva za homogenu katalizu. Međutim, sve veća potreba za ekološki prihvatljivijim alternativama rezultira intenzivnom potragom za nemetalnim katalizatorima, uključujući nemetalne hidridne donore, katalizatore za aktivaciju C-H veze, te aktivaciju N2, CH4 i drugih vrlo stabilnih molekula. Unutar ovog projekta predviđamo da su molekulski sustavi koji se temelje na bisfosfinima koji na atomima fosfora kao supstituente imaju jake elektrondonorske skupine vrlo snažni donori hidrida sposobni reducirati CO2. Nadalje, predviđamo da su ovi sustavi, ako se kombiniraju s jakim Lewisovim kiselinama, sposobni aktivirati dušik (N2) i metan (CH4). Ove hipoteze provjerit će se i potvrditi računalnim modeliranjem. Odabrane molekulske sustave ćemo istražiti eksperimentalno. Razvit ćemo metode za si ntezu perspektivnih bisfosfina, a novosintetizirane spojeve podvrgnut ćemo eksperimentalnoj evaluaciji. Osim znanstvenih rezultata u vidu publikacija u visokorangiranim časopisima, ovaj projekt je važan i jer otvara novi put istraživanja u Hrvatskoj te omogućuje prijenos znanja i ekspertize u području fosfinske kemije kroz sudjelovanje njemačkog partnera u timu. Dodatno, studenti uključeni u projekt steći će dragocjeno profesionalno iskustvo.]]></summary_hr><summary_en><![CDATA[Catalysis plays an important role in almost all branches of chemistry, making the development of efficient catalysts a constant challenge. Both experimental and computational approaches to catalyst design are very active in contemporary research, and their interplay leads to synergistic effects in the final result. The activation of small molecules by a suitable catalyst is the first step of many chemical transformations in the synthesis of new compounds and materials. Over the last 60 years, research in the field of organometallic chemistry has made an important contribution to catalyst design and has produced a large number of highly reactive and selective compounds for homogeneous catalysis. However, the increasing need for more environmentally friendly alternatives leads to an intensive search for metal-free catalysts, including metal-free hydride donors, catalysts for the activation of C-H bonds and the activation of N2, CH4 and other stable molecules. In this project, we propose that molecular systems based on bis-phosphines, in which the substituents on the phosphorus are strong electron-donating groups, are very powerful hydride donors that can reduce CO2. Furthermore, we foresee that these systems in combination with strong Lewis acids are able to activate dinitrogen (N2) and methane (CH4). All these hypotheses will be answered though computational study. Selected molecular systems will undergo experimental studies. Methods for the synthesis of perspective bis-phosphines will be developed and the prepared compounds will be evaluated experimentally. In addition to the scientific results in the form of publications in high-ranking journals, this project is also important because it opens up a new avenue of research in Croatia and enables the transfer of knowledge and expertise in the field of phosphine chemistry through the participation of the team&#39;s German partner. In addition, the students involved in the project will gain valuable professional experience.]]></summary_en></project><project>
<id>16751</id><title_hr><![CDATA[Razvoj metodologije za dokazivanje zemljopisnog porijekla i konvencionalnog/ekološkog uzgoja krumpira]]></title_hr><title_en><![CDATA[Development of methodology for verification of geographical origin and conventional/ecological production of potatoes ]]></title_en><user_id>20300</user_id><user_firstLast_name>Milan Poljak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2024-05</proposal_call><code>IP-2024-05-5900</code><acronim><![CDATA[EcoPGO]]></acronim><duration>10.12.2024 - 09.12.2027</duration><status>U tijeku</status><financ_value>199.580,50 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Prehrambena tehnologija, Interdisciplinarne biotehničke znanosti, </scie_field_hr><scie_field_en>Food technology, Interdisciplinary biotechnical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Agronomski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Agriculture]]></institution_en><team_members_id>23378, 25988, 20368, 25730, 4954, 4764, 1261, 865951, 862772, 866061, 2853, 24212, 19662, 24183, 865762, </team_members_id><team_members_names><![CDATA[Nataša Mikulec, Biljana Radeljević, Sanja Slunjski, Ante Biško, Boris Lazarević, Damir Iveković, Ivone Jakaša, Ines Peremin, Egon Rešetar, Marina Štivičić, Adela Krivohlavek, Ivana Mandic Andacic, Martina Ivešić, Maja Budeč, Magdalena Gavran, ]]></team_members_names><keywords_hr><![CDATA[Krumpir, zemljopisno porijeklo, omjer stabilnih izotopa, baza podataka, kemometrijske metode ]]></keywords_hr><keywords_en><![CDATA[Potato, geographical origin, stabile isotopic ratio, database, chemometrc methods ]]></keywords_en><summary_hr><![CDATA[U sve izraženijim uvjetima globalizacije tržišta, zemljopisno porijeklo poljoprivrednih proizvoda te način njihova uzgoja postaju ključni čimbenici koji utječu na odabir kupaca, vođenih interesom prema specifičnim osobinama regionalnih proizvoda, povjerenjem u sigurnost i kvalitetu lokalnih proizvoda te brigom o ekološkoj održivosti proizvodnje. Za razliku od analitičkih postupaka kojima se provjerava kvaliteta i zdravstvena ispravnost poljoprivrednih i prehrambenih proizvoda, koji su relativno jednostavni i dobro definirani, postupci za utvrđivanje zemljopisnog porijekla te načina uzgoja poljoprivrednih proizvoda znatno su kompleksniji te do danas nije razvijena jedinstvena analitička metodologija koja bi bila univerzalno primjenjiva za njihovo određivanje. Razlog tome je činjenica da uobičajeni fizikalno-kemijski parametri najčešće nisu dostatni za diferenciranje zemljopisnog porijekla, već ih je nužno kombinirati sa specifičnim organoleptičkim i (bio)kemijskim parametrima te parametrima specifično vezanim uz lokaciju. Prilikom provjere konvencionalnog/ekološkog načina uzgoja poljoprivrednih proizvoda, problem predstavlja uporaba sintetskih organskih i mineralnih gnojiva, koju je, za razliku od uporabe pesticida, analitički teško dokazati. U sklopu projekta razvit će se analitička metodologija utvrđivanja zemljopisnog porijekla te konvencionalnog/ekološkog uzgoja krumpira, kao modelnog poljoprivrednog proizvoda koji se uzgaja na cijelom geografskom području Rep. Hrvatske. Kao osnova za definiranje metodologije, projektom će se utvrditi minimalni skup fizikalno-kemijskih parametara koji omogućuje statistički relevantnu predikciju geografske lokacije uzgoja te provjeru načina uzgoja. Ciljani parametri obuhvaćaju omjere stabilnih izotopa 1H/2H, 12C/13C, 14N/15N i 16O/18O, sadržaj metala, analitički profil niskomolekulskih organskih i amino kiselina, sadržaj mono- i disaharida te morfološke značajke škrobnih granula, sadržaj amiloze i stupanj fosforilacije škroba.]]></summary_hr><summary_en><![CDATA[In increasingly globalized market conditions, the geographical origin of agricultural products and the method of their cultivation are becoming crucial factors that influence consumer choices guided by an interest in the specific characteristics of regional products, trust in the safety and quality of local products, and concern for the ecological production sustainability. Unlike analytical procedures used to verify the quality and safety of agricultural/food products, which are relatively simple and well-defined, methods for determining the geographical origin and cultivation methods of agricultural products are much more complex. To date, a unified analytical methodology that would be universally applicable for their determination has not been developed as standard physico-chemical parameters are often insufficient for differentiating geographical origin and it is necessary to combine them with specific organoleptic and (bio)chemical parameters and parameters specifically related to the location. When verifying conventional/organic farming practices, the use of synthetic fertilizers poses a challenge. Unlike the use of pesticides, it is analytically difficult to prove their use. Within the framework of the project, an analytical methodology will be developed to determine the geographical origin and conventional/organic cultivation of potatoes, serving as a model agricultural product grown throughout the Croatia. As a basis for defining the methodology, the project will determine the minimum set of physico-chemical parameters enabling statistically relevant prediction of the geographical location of cultivation and verification of the cultivation method. The targeted parameters include ratios of stable isotopes 1H/2H, 12C/13C, 14N/15N, and 16O/18O, metal content, analytical profile of low molecular weight organic and amino acids, content of mono- and disaccharides and amylose, morphological characteristics of starch granules, and degree of starch phosphorylation.]]></summary_en></project><project>
<id>16755</id><title_hr><![CDATA[Funkcionalni fotoreaktivni kromofori za primjene u organskoj sintezi i biologiji]]></title_hr><title_en><![CDATA[Functional Photoreactive Chromophores for Applications in Organic Synthesis and Biology]]></title_en><user_id>376</user_id><user_firstLast_name>Nikola Basaric</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2024-05</proposal_call><code>IP-2024-05-8565</code><acronim><![CDATA[FunPhotoAppSynBio]]></acronim><duration>09.12.2024 - 08.12.2027</duration><status>U tijeku</status><financ_value>192.050,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, Biologija, </scie_field_hr><scie_field_en>Chemistry, Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>21264, 647, 3971, 3775, 855930, 873017, </team_members_id><team_members_names><![CDATA[Mladena Glavaš, LIDIJA UZELAC, Dragana Vuk, Irena Škorić, Vilma Lovrinčević, Karla Karadža, ]]></team_members_names><keywords_hr><![CDATA[Fotokemija, Organska sinteza, Fotofizika, Fotokavezi, Fluorescentne boje, Foto-terapija karcinoma, BODIPY, Karbazoli, Bifenilamini]]></keywords_hr><keywords_en><![CDATA[Photochemistry, Organic synthesis, Photophysics, Photocages, Fluorescent dyes, Cancer photo-therapy, BODIPY, Carbazoles, Biphenylamines]]></keywords_en><summary_hr><![CDATA[Fotokemija je važno multidisciplinarno znanstveno područje na začelju istraživanja u kemiji, fizici i biologiji, s brojnim primjenama u modernim tehnologijama. Suština istraživanja u fotokemiji usmjerena je na razvoj novih funkcionalnih kromofora s različitim primjenama. U okviru predloženog projekta radit ćemo na tri kromofora, BODIPY, karbazolima i bifenilaminima, njihovoj sintezi i istraživanju fotofizičkih svojstava i fotokemijske reaktivnosti. Nadalje, pokušat ćemo pronaći primjenu ovih kromofora u organskoj sintezi i biologiji. BODIPY derivati su izvrsna fluorescentna bojila koja će se istraživati kako bi se razvile nove zaštitne skupine koje se uklanjaju u fotoreakcijama (fotokavezi) i unutarstanične fluorescentne boje ili prijenosnici lijekova. Derivati karbazola bit će pripravljeni s ciljem razvoja nove linije protutumorskih foto-terapeutika koji svoje djelovanje temelje na fotogeneriranju aza-kinon metida (aza-QM), a ne singletnog kisika. Nadalje, radit ćemo na objašnjenju reakcijskog mehanizma stvaranja aza-QM-a i njihovoj upotrebi u sintezi složenih aza-heterocikala. Derivati bifenilamina istraživat će se kao potencijalni fotokavezi koji apsorbiraju vidljivu svjetlost u dvofotonskoj apsorpciji i mogu se koristiti u biologiji. Uz fundamentalni karakter predloženog istraživanja, cilj nam je ići dalje od trenutnog stanja tehnike i tražiti primjene, ne samo u organskoj sintezi, već i u biomedicini, kroz razvoj novih foto-aktivirajućih lijekova ili novih fluorescentnih reagensa za bojenje organela u mikroskopiji. Predviđa se da će FunPhotoAppSynBio tim pronaći niz funkcionalnih kromofora s biološkim aktivnostima (hit molekule), koji će se dalje optimirati prema lead-molekulama. To će pomoći u razvoju novih fluorescentnih alata u dijagnostici i foto-liječenju raka s minimalnim nuspojavama, uz dobrobit za cijelo društvo.]]></summary_hr><summary_en><![CDATA[Photochemistry is an important multidisciplinary scientific field at the forefront of research in chemistry, physics and biology, with numerous applications in modern technologies. Quintessence of the research in photochemistry is focused on the development of new functional chromophores with different applications. Within the proposed project we will work on three chromophores, BODIPY, carbazoles and biphenylamines, their synthesis and investigation of the photophysical properties and photochemical reactivity. Furthermore, we will try to find the applications of these chromophores in organic synthesis and biology. The BODIPY derivatives are excellent fluorescent dyes which will be investigated to develop new photo-cleavable protective groups (photocages) and intracellular fluorescent labels or drug delivery vehicles. The carbazole derivatives will be made with the aim to develop new line of cancer photo-therapeutics that base their action on generation of aza-quinone methides (aza-QM), and not singlet oxygen. Furthermore, we will work on the elucidation of reaction mechanism of aza-QM generation and its use in the synthesis of complex aza-heterocycles. The biphenylamine derivatives will be investigated as potential two-photon absorbing photocages that absorb visible light and can be used in biology. In addition to the fundamental character of the proposed investigation, we aim to go beyond the state of the art and seek applications, not only in organic synthesis, but also in biomedicine, such as development of new photo-activable drugs or new fluorescent reagents for the staining of organelles in microscopy. It is anticipated that the FunPhotoAppSynBio team will find a number of functional chromophores with biological activities (hit molecules), which will be further improved towards lead molecules. This will help in the development of new fluorescent tools in diagnostics and photo-treatments for cancer with minimal side-effects, with benefits to the whole society.]]></summary_en></project><project>
<id>16762</id><title_hr><![CDATA[Žene i žensko u srednjovjekovnom i ranonovovjekovnom glagoljaštvu]]></title_hr><title_en><![CDATA[Women and the Feminine in Mediaeval and Early Modern Glagolitic Culture]]></title_en><user_id>6756</user_id><user_firstLast_name>Ana Šimić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2024-05</proposal_call><code>IP-2024-05-8346</code><acronim><![CDATA[FEMIGLA]]></acronim><duration>20.12.2024 - 19.12.2027</duration><status>U tijeku</status><financ_value>74.444,00 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filologija, Teologija, Povijest, Povijest umjetnosti, </scie_field_hr><scie_field_en>Philology, Theology, History, Art history, </scie_field_en><institution_hr><![CDATA[Staroslavenski institut]]></institution_hr><institution_en><![CDATA[Old Church Slavonic Institute in Zagreb]]></institution_en><team_members_id>735, 867775, 5066, 867801, 12754, 867810, 22693, 868205, 1119, 868041, </team_members_id><team_members_names><![CDATA[Sanja Cvetnić, Dajana Ćosić, Dolores Grmača, Igor Medić, Ana Mihaljević, Jurica Polančec, Saša Potočnjak, Domagoj Runje, Jozo Vela, Giorgio Ziffer, ]]></team_members_names><keywords_hr><![CDATA[žene, žensko, glagoljaštvo, srednji vijek, analiza teksta, interdisciplinarnost]]></keywords_hr><keywords_en><![CDATA[women, the feminine, Glagolitic culture, Middle Ages, text analysis, interdisciplinarity]]></keywords_en><summary_hr><![CDATA[Sadašnje stanje statusa žene, kao važnoga pokazatelja naprednosti nekoga društva, ne može se razumjeti bez poznavanja prošlosti. U hrvatskom je kontekstu najstarija prošlost povezana sa srednjim vijekom, razdobljem u kojem je glagoljaštvo odigralo presudnu ulogu za hrvatsku povijest.Projekt &#39;&#39;Žene i žensko u srednjovjekovnom i ranonovovjekovnom glagoljaštvu&#39;&#39; posvećen je jezikoslovnim, književnim, liturgijskim, kulturnopovijesnim i povijesnoumjetničkim istraživanjima žena i ženskoga u korpusu srednjovjekovnih i ranonovovjekovnih glagoljskih tekstova. Projekt će usmjeriti pozornost na gramatički, onomastički i onomasiološki vid govora o ženama i ženskom, glavne i sporedne ženske likove u liturgijskim i neliturgijskim tekstovima, ženidbu i brak u ćirilometodskim izvorima, starocrkvenoslavenskim tekstovima i hrvatskoglagoljskim liturgijskim knjigama, ženski udio u produkciji i konzumaciji glagoljaške kulture te ikonografiju ženskih likova na sitnoslikama hrvatskoglagoljskih knjiga. Očekivani su rezultati projekta: 25 znanstvenih radova, 2 popularno-znanstvena rada, katalog svetica, hrestomatija tekstova o ženama u zadanom glagoljaškom korpusu, 21 izlaganje na znanstvenim konferencijama (bez izlaganja na projektnoj konferenciji), 2 istraživačke radionice, projektna konferencija, izložba i 3 javna predavanja.Žene i žensko dosad nisu ni ciljano ni sustavno istraživani na glagoljaškoj kulturi. Projekt će pridonijeti boljemu poznavanju statusa žene u najstarijoj hrvatskoj povijesti i boljemu poznavanju glagoljaštva, predmoderne hrvatske književnosti, povijesti hrvatskoga jezika, povijesti hrvatske knjige, crkvene, kulturne i društvene povijesti hrvatskoga naroda i europskoga konteksta koji ga je uvjetovao. Uključenost suradnika iz različitih znanstvenih polja humanističkoga područja osigurava inovativnost koja će pridonijeti rasvjetljavanju teme žena i ženskoga u glagoljaštvu te aktualizaciji te teme i danas.]]></summary_hr><summary_en><![CDATA[As an important indicator of societal progress, the current status of women cannot be fully understood without an understanding of its past. The Middle Ages are the earliest Croatian historical period; throughout this period, Glagolitic culture had a major impact on Croatian history.	Research on women and the feminine in the corpus of Mediaeval and early Modern Glagolitic texts is the focus of the project “Women and the Feminine in Mediaeval and Early Modern Glagolitic Culture“. It includes linguistic, literary, liturgical, cultural history, and art history studies. Notably, the project will examine how women were described in the grammatical, onomastic, and onomasiological sense; women as main and supporting characters in (non-)liturgical texts; marriage rites and marriage in Cyrillo-Methodian sources and Croatian Glagolitic liturgical books; women participating in the production and consumption of Glagolitic culture; and the iconography of female figures on miniatures in Croatian Glagolitic books.The planned results are: 25 scientific papers, 2 popular scientific papers, a catalogue of female saints, a chrestomathy of texts about women in the defined Glagolitic corpus, 21 presentations at scientific conferences (not including presentations at the project conference), 2 research workshops, a project scientific conference, an exhibition, and 3 public lectures.Women and the feminine have not yet been systematically researched in Glagolitic culture. The proposed project will contribute to improved knowledge of women in pre-Modern Croatian history, as well as of Croatian Glagolitic culture, pre-Modern Croatian literature, the history of the Croatian language and books, the Mediaeval Croatian history and the European context that conditioned it. The involvement of researchers from a variety of scientific disciplines in the humanities will ensure innovation in shedding light on the topic of women and the feminine in Glagolitic culture, making it relevant even today.]]></summary_en></project><project>
<id>16765</id><title_hr><![CDATA[Termodinamički, spektroskopski i strukturni aspekti koordinacijskih reakcija kaliksarena]]></title_hr><title_en><![CDATA[Thermodynamic, spectroscopic, and structural aspects of calixarene coordination reactions]]></title_en><user_id>7690</user_id><user_firstLast_name>Vladislav Tomišić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2024-05</proposal_call><code>IP-2024-05-3012</code><acronim><![CDATA[CalixCORE]]></acronim><duration>09.12.2024 - 08.12.2027</duration><status>U tijeku</status><financ_value>199.975,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>29449, 865152, 22634, 12384, 310, 863818, 348, 7725, 12733, 868128, 21393, 873037, </team_members_id><team_members_names><![CDATA[Andrea Usenik, Matija Modrušan, Katarina Leko, Gordan Horvat, Vladimir Stilinović, Marija Cvetnić, Leo Frkanec, Mladen Žinić, Nikola Bregović, Angela F. Danil de Namor, Dajana Barišić, Franka Sunjka, ]]></team_members_names><keywords_hr><![CDATA[receptori, kaliksareni, inkluzijski kompleksi, supramolekulske kapsule i polimeri, termodinamika, solvatacija, hidrofobni efekt, fluorescencija]]></keywords_hr><keywords_en><![CDATA[receptors, calixarenes, inclusion complexes, supramolecular capsules and polymers, thermodynamics, solvation, hydrophobic effect, fluorescence]]></keywords_en><summary_hr><![CDATA[Efikasni i selektivni makrociklički receptori iona i neutralnih molekula odigrali su važnu ulogu u razvoju i primjeni supramolekulske kemije. Među njima posebno mjesto zauzimaju derivati kaliksarena na čiji će se dizajn, sintezu i fizikalno-kemijsku karakterizaciju usredotočiti ovaj projekt. Priredit će se niz derivata s različitim brojem funkcionaliziranih fenolnih podjedinica te se očekuje da će dobiveni spojevi imati velik afinitet za vezanje raznih monoatomnih i molekulskih iona i neutralnih vrsta. Jedan od ciljeva projekta je razviti iznimno osjetljive fluorescentne senzore. Pri tome će biti primijenjena naša nedavna saznanja vezana uz intrinzičnu fluorescenciju kaliksarena te će ta pojava biti detaljno istražena. Posebna će pažnja biti posvećena derivatima sa supstituentima koji ih čine zadovoljavajuće topljivima u vodi. Dio istraživanja bit će usmjeren k razvoju kaliksarenskih kapsula i polimera te na funkcionalizaciju površina komplementarnim kaliksarenskim derivatima. Detaljno će biti istražen utjecaj solvatacije na ravnoteže reakcija kompleksiranja, s naglaskom na inkluziju molekula otapala u hidrofobnu kaliksarensku šupljinu. S tim u vezi, ispitat će se receptorski potencijal kaliksarena za različite hidrofobne i (super)kaotropne vrste. Procesi kompleksiranja i solvatacije proučit će se sveobuhvatnim pristupom koji uključuje termodinamička, strukturna i računalna istraživanja. Koristit će se čitav niz eksperimentalnih (mikrokalorimetrija, fluorimetrija, UV-Vis i NMR spektroskopija, potenciometrija, konduktometrija, rentgenska strukturna analiza) i komputacijskih (simulacije molekulske dinamike, teorija funkcionala gustoće) metoda. Takav pristup omogućit će pouzdano određivanje termodinamičkih veličina (konstante stabilnosti, Gibbsove energije, entalpije i entropije kompleksiranja i otapanja) te strukturnih značajki receptora i njihovih kompleksa. Dobivene informacije pružit će detaljan uvid u ključne čimbenike koji određuju ishod proučavanih procesa.]]></summary_hr><summary_en><![CDATA[Efficient and selective macrocyclic receptors for ions and neutral molecules have played an important role in the development of supramolecular chemistry. Among the most important ones are calixarenes, which prompted us to devote research to the design, synthesis, and physicochemical characterization of these compounds and their complexation reactions. A series of derivatives with varying number of functionalized phenolic subunits will be prepared to obtain receptors with exceptional binding affinities towards monoatomic and molecular ions and neutral species. Some of these are aimed to be highly sensitive fluorescent sensors. With this respect, our recent findings regarding the intrinsic fluorescence of calixarenes will be implemented and this phenomenon will be studied in detail. Water-soluble derivatives and their binding abilities in aqueous medium will be especially addressed. An important objective will be development of calixarene capsules and polymers as well as functionalization of surfaces with complementary calixarenes. Particular attention will be paid to the solvation effects on binding reactions, with the emphasis on the inclusion of solvent molecules into the calixarene cavity. Furthermore, calixarene derivatives will be probed as potential receptors for various hydrophobic and (super)chaotropic compounds. Integrated thermodynamic, structural, and computational studies of complexation and solvation processes will be carried out. Several experimental (ITC, fluorimetry, UV-Vis and NMR spectroscopy, potentiometry, conductometry, X-ray diffraction) and computational (MD, DFT) methods will be employed. That will enable reliable determination of thermodynamic quantities (stability constants, reaction and solution Gibbs energies, enthalpies, and entropies) as well as structural characteristics of the receptors and their complexes. The obtained information will provide a detailed insight into the key factors determining the studied complexation equilibria.]]></summary_en></project><project>
<id>16766</id><title_hr><![CDATA[Implementacija piezoelektričnih generatora pomaka i naprednih algoritama za smanjenje šuma u mjerenju teksture površina]]></title_hr><title_en><![CDATA[Implementation of Piezoelectric Displacement Generators and Advanced Noise Reduction Algorithms in Surface Texture Measurement]]></title_en><user_id>23340</user_id><user_firstLast_name>Gorana Baršić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2024-05</proposal_call><code>IP-2024-05-3450</code><acronim><![CDATA[NANO-SURF]]></acronim><duration>10.12.2024 - 09.12.2027</duration><status>U tijeku</status><financ_value>91.080,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, </scie_field_hr><scie_field_en>Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>24281, 20122, 871177, </team_members_id><team_members_names><![CDATA[Vedran Šimunović, Marko Katić, Vilim Kozuh, ]]></team_members_names><keywords_hr><![CDATA[uređaji za mjerenje teksture, numeričke metode za smanjenje šuma, piezoelektrični generatori pomaka, interferometri, umjeravanje, mjerna nesigurnost]]></keywords_hr><keywords_en><![CDATA[stylus instrument, numerical methods for noise reduction, piezoelectric displacement generators, interferometers, calibration, measurement uncertainty]]></keywords_en><summary_hr><![CDATA[Uređaji s ticalom su najčešće korišteni mjerni sustavi za ispitivanje stanja teksture površine. Sve uže definirane granice tolerancija, posebice u poluvodičkoj industriji kao i u medicinskoj i farmaceutskoj industriji postavljaju nove izazove u području mjeriteljstva tekstura površina. Jedini način da se odgovori na postavljene zahtjeve jest smanjiti mjernu nesigurnost rezultata mjerenja. Kako bi to postigli nužno je smanjiti šum koji se „ugradio“ u sam mjerni rezultat s obzirom na to da je upravo šum jedan od dva najveća doprinosa u procijeni nesigurnosti rezultata mjerenja. Drugi najveći doprinos mjernoj nesigurnosti je nesigurnost etalona koji se koriste u postupku umjeravanja uređaja s ticalom.Cilj ovog istraživačkog projekta je ostvariti nesigurnost rezultata umjeravanja uređaja s ticalom ispod 100 nm. Projekt će se fokusirati na implementaciju naprednih tehnika smanjenja šuma te uporabu piezoelektričnog generatora pomaka u postupku umjeravanja uređaja s ticalom, kako bi se postigla visoka preciznost i pouzdanost rezultata mjerenja hrapavosti uz postizanje ciljane mjerne nesigurnosti rezultata umjeravanja. Projektom se teži unaprijediti znanstvena saznanja o novim postupcima osiguravanja sljedivosti uređaja za mjerenje  teksture površine kao i istraživanju primjene metoda za smanjenje šuma u signalu, što predstavlja vrhunac suvremenih znanstvenih istraživanja u ovom području. Realizacijom projektnih ciljeva, Nacionalni laboratorij za duljinu Republike Hrvatske imat će priliku priključiti se vrlo uskom krugu vodećih znanstvenoistraživačkih organizacija koje trenutno rade na predmetnim znanstvenim istraživanjima, a koje će definirati budućnost mjerenja teksture površina.]]></summary_hr><summary_en><![CDATA[Stylus instruments are the most used measurement systems for examining surface texture conditions. Increasingly narrow tolerance limits, especially in the semiconductor industry as well as in medical and pharmaceutical industries, pose new challenges in the field of surface texture metrology. The only way to meet these requirements is to reduce the measurement uncertainty of results. To achieve this, it is necessary to reduce the noise embedded in the measurement result, as noise is one of the two largest contributors to the uncertainty of measurement results. The other significant contributor to measurement uncertainty is the uncertainty of the standards used in the calibration of stylus instruments.The goal of this research project is to achieve uncertainty of calibration results for stylus instruments below 100 nm. The project will focus on implementing advanced noise reduction algorithms and the use of piezo displacement generators for calibrating stylus instruments, aiming to achieve high precision and accuracy of roughness measurement results while meeting the targeted measurement uncertainty.The project aims to enhance scientific knowledge about new procedures for ensuring traceability of surface texture measurement devices and researching methods for noise reduction in signals, representing the cutting edge of scientific research in this field. By achieving these project goals, the Croatian National Laboratory for Length will have the opportunity to join a very exclusive group of leading scientific research organizations currently working on this scientific research, which will define the future of surface texture measurements.]]></summary_en></project><project>
<id>16770</id><title_hr><![CDATA[Uloga genetike, biološke dobi i karakteristika mišićnih vlakana u razvoju talenta i sportskoj izvedbi:  &#39;&#39;Studija na blizancima&#39;&#39;]]></title_hr><title_en><![CDATA[The Interplay of Genetics, Biological Age, and Muscle Fiber Characteristics in Talent Development and Athletic Performance: “A Twin Study”]]></title_en><user_id>784</user_id><user_firstLast_name>Dražen Čular</user_firstLast_name><svouser_id>868094</svouser_id><svouser_firstLast_name>Armin Paravlic</svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2024-05</proposal_call><code>IP-2024-05-8340</code><acronim><![CDATA[&#39;&#39;TWINSWINS&#39;&#39;]]></acronim><duration>20.12.2024 - 19.12.2027</duration><status>U tijeku</status><financ_value>199.200,00 eur</financ_value><scie_area_hr>Društvene znanosti, Biomedicina i zdravstvo, Biotehničke znanosti, </scie_area_hr><scie_area_en>Social sciences, Biomedicine and health sciences, Biotechnical sciences, </scie_area_en><scie_field_hr>Kineziologija, Temeljne medicinske znanosti, Sociologija, Biotehnologija u biomedicini, </scie_field_hr><scie_field_en>Kinesiology, Basic Medical Sciences, Sociology, Biotechnology in Biomedicine, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Kineziološki fakultet]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Kinesiology]]></institution_en><team_members_id>867953, 18978, 4737, 1253, 4560, 865174, 866696, 868094, 19053, 871138, 872835, </team_members_id><team_members_names><![CDATA[Joseph Baker, Johnny Padulo, Damir Zubac, Ana Kezić, Vladimir Ivančev, Matej Babić, Tea Gutović, Armin Paravlic, Marijana Čavala, Darko Katović, Dino Belošević, ]]></team_members_names><keywords_hr><![CDATA[Genetika, DNA, biološka dob, sazrijevanje, sportska izvedba, karakteristike mišićnih vlakana, sportski talenti, Monozygotic Twins; Dizygotic Twin]]></keywords_hr><keywords_en><![CDATA[Genetics, DNA, Biological age, Maturation, Athletic Performance, Muscle fiber characteristics,, sport talents;, Monozygotic Twins; Dizygotic Twin]]></keywords_en><summary_hr><![CDATA[Bilateralni Hrvatsko-Slovenski multidisciplinarni Projekt &#39;&#39;Uloga genetike, biološke dobi i karakteristika mišićnih vlakana u razvoju talenta i sportskoj izvedbi: Studija na blizancima&#39;&#39; (TWINSWINS) istražuje kako genetski, biološki i okolišni čimbenici utječu na razvoj sportskih talenta. Projekt se temelji se na prethodnim istraživanjima koja su pokazala potrebu za poboljšanjem procesa razvoja mladih sportaša  Uključujući multidisciplinarne stručnjake iz kineziologije, biomedicine, biotehnologije i sociologije, projekt koristi neinvazivne suvremene tehnologije poput tensiomiografije (TMG), termografije i ultrazvučne procjene koštane dobi (SonicBone) za analizu mladih hrvatskih sportaša uključujući i uzorak jednojajčanih/dvojajčanih blizanca i njihovih roditelja. Cilj je unaprijediti dijagnostičke alate kako bi se omogućilo preciznije praćenje i razvoj mladih sportaša. Očekuje se da će rezultati  unaprijediti identifikaciju i razvoj mladih sportaša, pružajući bolje razumijevanje efekta relativne dobi (RAE) i genetskih predispozicija. Znanstveni doprinosi uključuju publiciranje rezultata u prestižnim časopisima i pohranu podataka u otvorene baze, omogućavajući daljnje analize. Društvenokorisni učinci projekta su poboljšanje treninga i selekcije, što može smanjiti sportske ozljede, i odustajanje od bavljenja sportom. Krajnji korisnici su sportaši, roditelji, treneri, sportske akademije, klubovi, nacionalni sportski savezi, obrazovne institucije i sportski radnici. &#39;&#39;TWINSWINS&#39;&#39; projekt  može transformirati pristup treniranju, potičući holistički pristup u razvoju mladih sportaša koji uzima u obzir etiku, genetiku, okoliš i biološku dob, pridonoseći znanstvenoj zajednici i društvenoj primjeni u sportu i obrazovanju.]]></summary_hr><summary_en><![CDATA[The Croatian-Slovenian bilateral multidisciplinary project &#39;&#39;The Role of Genetics, Biological Age, and Muscle Fiber Characteristics in Talent Development and Sports Performance: A Twin Study&#39;&#39; (TWINSWINS) explores how genetic, biological, and environmental factors influence the development of sports talents. The project is based on previous research that has demonstrated the need to improve the developmental processes of young athletes. Including multidisciplinary experts from kinesiology, biomedicine, biotechnology, and sociology, the project utilizes non-invasive modern technologies such as Tensiomyography (TMG), thermography, MyotonPRO Muscle Talent Scan magnetic resonance imaging measurements , and ultrasonic assessment of bone age (SonicBone) to analyze young Croatian athletes, including a sample of monozygotic/dizygotic twins and their parents. The goal is to enhance diagnostic tools to enable more precise monitoring and development of young athletes. The results are expected to improve the identification and development of young athletes, providing a better understanding of the Relative Age Effect (RAE) and genetic predispositions. Scientific contributions include publishing results in prestigious journals and storing data in open databases, enabling further analysis. The project&#39;s societal benefits include improved training and selection processes, which can reduce sports injuries and dropout rates. The end-users are athletes, parents, coaches, sports academies, clubs, national sports associations, educational institutions, and sports professionals. TWINSWINS could transform the approach to training, promoting a holistic approach to the development of young athletes that considers ethics, genetics, the environment, and biological age, contributing to the scientific community and social application in sports and education.]]></summary_en></project><project>
<id>16776</id><title_hr><![CDATA[Potencijal primjene plazmom aktivirane vode na funkcionalne komponente hrane ]]></title_hr><title_en><![CDATA[The potential of plasma-activated water application on functional food components ]]></title_en><user_id>493</user_id><user_firstLast_name>Tomislava Vukušić Pavičić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2024-05</proposal_call><code>IP-2024-05-9863</code><acronim><![CDATA[PAWerful]]></acronim><duration>09.12.2024 - 08.12.2027</duration><status>U tijeku</status><financ_value>199.091,08 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Prehrambena tehnologija, Interdisciplinarne biotehničke znanosti, </scie_field_hr><scie_field_en>Food technology, Interdisciplinary biotechnical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Food Technology and Biotechnology]]></institution_en><team_members_id>590, 206, 453, 1243, 5243, 6106, 1062, 867884, 856063, 872960, </team_members_id><team_members_names><![CDATA[Višnja Stulić, Zoran Herceg, Jasna Mrvčić, Verica Dragović-Uzelac, Irena Barukčić Jurina, Katarina Lisak Jakopović, Sandra Pedisić, Franka Markić, Ivan Karlo Cingesar, Marta Brkljačić, ]]></team_members_names><keywords_hr><![CDATA[plamom aktivirana voda, stabilnost radikala, funkcionalne komponente hrane, antimikrobna svojstva, parametri kvalitete]]></keywords_hr><keywords_en><![CDATA[ PAW, rective species stability, functional food components, antimicrobial, quality parametres]]></keywords_en><summary_hr><![CDATA[Plazmom aktivirana voda (engl. Plasma activated water – PAW) dobivena je plazma pražnjenjem koje u vodi stvara  velik broj različitih reaktivnih vrsta poput iona, slobodnih radikala, te pobuđenih molekulski vrsta (kisikovih i dušikovih spojeva, vodikova peroksida, ozona, atomarnog kisika, hidroksilnog radikala itd.). Zbog novonastalog kemijskog sastava pokazuje antimikrobno djelovanje, te se može učinkovito koristiti u dezinfekcijske svrhe u prehrambenoj industriji. S obzirom da spada u ne toplinske metode pogodna je za primjenu na toplinski osjetljivoj hrani poput minimalno procesiranih proizvoda. Kroz ovaj projektni prijedlog cilj je kroz tri istraživačka razdoblja ispitati svojstva PAW te mogućnost direktne primjene na hranu. Specifičan kemijski sastav potrebno je karakterizirati, te odrediti stabilnost vode tijekom skladištenja, kao i antimikrobna svojstva na česte mikrobiološke kontaminante hrane. U drugoj fazi istraživanja potrebno je ispitati i utjecaj na funkcionalne komponente hrane (proteine, enzime, lipide i ugljikohidrate) s ciljem određivanja mogućnosti direktne primjene PAW na minimalno procesirane proizvode. U završnoj trećoj fazi istražiti će se mogućnost primjene PAW u direktnom kontaktu s hranom tijekom uranjanja (voća, povrća) i dozrijevanja (feta sir), te odrediti rok trajnosti uz praćenje parametara kvalitete minimalno procesiranih proizvoda prethodno tretiranih PAW. Uz primjenu sofisticiranih metoda, te praćenje velikog broja parametara cilj je dobiti što bolji uvid u potencijal primjene plazmom aktivirane vode u prehrambenoj industriji. ]]></summary_hr><summary_en><![CDATA[Plasma-activated water (PAW), obtained through plasma discharge, contains a variety of reactive species such as ions, free radicals, and excited molecular species (oxygen and nitrogen compounds, hydrogen peroxide, ozone, atomic oxygen, hydroxyl radicals, etc.). This unique chemical composition gives PAW antimicrobial properties, making it suitable for disinfection in the food industry. Being a non-thermal method, PAW is ideal for treating heat-sensitive foods like minimally processed products. The proposed project aims to explore PAW properties and their direct application to food over three research phases. The first phase involves characterizing the specific chemical composition of PAW, assessing its stability during storage, and evaluating its antimicrobial effectiveness against common microbiological food contaminants. In the second phase, the impact of PAW on the functional components of food (proteins, enzymes, lipids, and carbohydrates) will be examined to determine its suitability for direct application to minimally processed products. In the final third phase, the possibility of applying PAW in direct contact with food during immersion (fruit, vegetables) and ripening (feta cheese) will be investigated, and the shelf life will be determined while monitoring the quality parameters of minimally processed products previously treated with PAW. By employing sophisticated methods and monitoring numerous parameters, the project aims to gain comprehensive insights into the potential of using plasma-activated water in the food industry. ]]></summary_en></project><project>
<id>16779</id><title_hr><![CDATA[Epistemička demokracija u digitalno doba]]></title_hr><title_en><![CDATA[Epistemic Democracy in a Digital Era]]></title_en><user_id>19830</user_id><user_firstLast_name>Ivan Cerovac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2024-05</proposal_call><code>IP-2024-05-4113</code><acronim><![CDATA[EDDD]]></acronim><duration>16.12.2024 - 15.12.2027</duration><status>U tijeku</status><financ_value>128.270,28 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filozofija, </scie_field_hr><scie_field_en>Philosophy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Filozofski fakultet u Rijeci]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>4207, 4388, 23388, 1453, 868253, 868255, 17857, 873023, </team_members_id><team_members_names><![CDATA[Snježana Prijić-Samaržija, Benedikt Perak, Tomislav Furlanis, Elvio Baccarini, Vojko Strahovnik, Mateja Centa Strahovnik, Kristina Lekić Barunčić, Hana Samaržija, ]]></team_members_names><keywords_hr><![CDATA[Demokracija, pravednost, umjetna inteligencija, legitimnost, fake news]]></keywords_hr><keywords_en><![CDATA[Democracy, Justice, Artificial Intelligence, Legitimacy, Fake news]]></keywords_en><summary_hr><![CDATA[Projekt se bavi analizom utjecaja koji digitalne tehnologije imaju na procedure demokratskog odlučivanja i na njihovu sposobnost da stvaraju legitimne političke odluke. Polazeći od teorije epistemičke demokracije, proučava se kako digitalne tehnologije utječu na pravičnost demokratskih procedura, kao i na njihovu epistemičku kvalitetu. Projektom se sistematizira postojeće znanje, analizira se kako odrediti okvire relevantnih tema, te se proučava koje se moralne i epistemičke vrijednosti mogu koristiti za uspostavljanje relevantnih evaluativnih standarada. Ovi standardi pak omogućuju utvrditi koji su relevantni problemi i kako ih se treba definirati u političkom kontekstu. ]]></summary_hr><summary_en><![CDATA[This research focuses on the effects digital technologies have on democratic decision-making procedures and on their ability to produce legitimate political decisions. Building upon the theory of epistemic democracy, the research investigates how digital technologies affect both the fairness of democratic procedures and their epistemic values, i.e., their ability to produce quality outcomes. It systemizes the existing knowledge, analyzes how issues are framed, and investigates which moral and epistemic considerations can be used for establishing the relevant evaluative standards. These standards help us determine what the relevant problems are and how these problems should be defined and understood in a political context.]]></summary_en></project><project>
<id>16780</id><title_hr><![CDATA[Rana disciplinarna pismenost na hrvatskome: obilježja udžbeničkoga diskursa ]]></title_hr><title_en><![CDATA[Early Disciplinary Literacy in Croatian: Features of Textbook Discourse ]]></title_en><user_id>7052</user_id><user_firstLast_name>Lidija Cvikić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2024-05</proposal_call><code>IP-2024-05-2755</code><acronim><![CDATA[RAPID]]></acronim><duration>10.12.2024 - 09.12.2027</duration><status>U tijeku</status><financ_value>117.621,00 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filologija, </scie_field_hr><scie_field_en>Philology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Učiteljski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Teacher Education]]></institution_en><team_members_id>5121, 12943, 867973, 866407, 22675, 13079, 19851, 867874, 20102, 26787, 867933, 867821, 865957, 873475, </team_members_id><team_members_names><![CDATA[Katarina Aladrović Slovaček, Emina Berbić Kolar, Rona Bušljeta Kardum, Marko Ćaleta, Gordana Dobravac, Dubravka Glasnović Gracin, Višnja Pavičić Takač, Katarina Širanović, Ivana Trtanj, Tamara Turza-Bogdan, Perica Vujić, Tanja Maltar Okun, Jelena Parizoska Parizoska, Martina Podboj, ]]></team_members_names><keywords_hr><![CDATA[udžbenički diskurs, hrvatski jezik, disciplinarna pismenost,  korpusna analiza, analiza diskursa, ovladavanje materinskim jezikom]]></keywords_hr><keywords_en><![CDATA[textbook discourse, Croatian language, disciplinary literacy, corpus analysis, discourse analysis, mother language acquisition]]></keywords_en><summary_hr><![CDATA[Cilj je projekta odrediti obilježja hrvatskoga udžbeničkoga diskursa namijenjenoga razvoju rane disciplinarne pismenosti (1.–6. razred osnovne škole). Opća i disciplinarne pismenosti temelji su ključnih kompetencija za cjeloživotono učenje, no rezultati PISA istraživanja pokazuju da 20%-30% hrvatskih učenika nije postiglo čak ni osnovnu razinu disciplinarne pismenosti. U projektu se polazi od pretpostavke da je ovladavanje jezikom određene discipline nužno za razvoj disciplinarne pismenosti budući da je znanje nerazdvojivo od jezika kojim se ono oblikuje i prenosi. U tom smislu udžbenik ima dvostruku ključnu ulogu: on je izvor znanja i jezičnoga unosa nužnoga za razvoj disciplinarne pismenosti. Unatoč važnosti, jezik hrvatskih disciplinarnih udžbenika još uvijek je neistražena tema. U svrhu ostvarivanja cilja projekta prikupit će se korpus udžbeničkog diskursa koji obuhvaća 60 udžbenika od 1. do 6. razreda iz triju predmeta (Priroda i društvo/Priroda, Matematika i Povijest), kao temelja za razvoj ostalih disciplinarnih pismenosti. Udžbenički se diskurs promatra kao višeslojan i dinamičan entitet koji čini jezična i nejezična (vizualna) sastavnica. Stoga će se primijeniti mješovita metoda istraživanja objedinjavajući analizu diskursa i postupke korpusne lingvistike. S obzirom na disciplinu i dob učenika (razred) odredit će se: a) morfološka, sintaktička i leksička obilježja udžbeničkoga diskursa; b) jezične strukture kojima se u hrvatskome iskazuju temeljni koncepti, kategorije i funkcije pojedine discipline; c) načini uspostavljanja unutarnje strukture teksta te odnosa između autora i primatelja (metadiskurs). Uz nove jezikoslovne spoznaje, rezultati projekta (jezgreni rječnik, model glosara temeljnih koncepata i jezičnih funkcija, publikacija koja uključuje smjernice za učitelje i autore udžbenika) imat će široku primjenu i snažan učinak na obrazovni sustav. ]]></summary_hr><summary_en><![CDATA[The project aims to determine the characteristics of Croatian textbook discourse intended for the development of early disciplinary literacy (grades 1-6 of primary school). General and disciplinary literacy are the foundations of key competencies for lifelong learning. However, PISA findings reveal that 20%-30% of Croatian students fall below the basic threshold in disciplinary literacy. The project assumes that mastering the language of a specific discipline is necessary for the development of disciplinary literacy, since knowledge is inseparable from the language in which it is shaped and transmitted. In this regard, the textbook plays a dual key role: as a source of knowledge and as linguistic input essential for disciplinary literacy development. Despite its importance, the language of Croatian disciplinary textbooks remains an underexplored topic. To achieve the project&#39;s goal, a corpus of textbook discourse will be collected, comprising 60 textbooks for grades 1-6 of three subjects (Nature and Society/Nature, Mathematics, and History), as the foundation for the development of other disciplinary literacies. Textbook discourse is observed as a multi-layered and dynamic entity consisting of linguistic and non-linguistic (visual) components. Therefore, a mixed method will be employed, combining discourse analysis and corpus linguistics procedures. In relation to the discipline and the students’ age (school grade), it will be determined: a) morphological, syntactic, and lexical characteristics of textbook discourse; b) linguistic structures used to express concepts, categories, and functions; c) ways of establishing text internal structure and the author–recipient relationship (metadiscourse). Alongside new linguistic insights, the project results (core vocabulary, model glossary of basic concepts and linguistic functions, a publication containing guidelines for teachers and textbook authors) will have a wide application and a strong impact on the education system.]]></summary_en></project><project>
<id>16789</id><title_hr><![CDATA[Analitičke, numeričke i eksperimentalne metode za identifikaciju Cosseratovih parametara materijala]]></title_hr><title_en><![CDATA[Analytical, Numerical and Experimental Methods for Identification of Cosserats&#39; Parameters of Materials]]></title_en><user_id>527</user_id><user_firstLast_name>Gordan Jelenić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2024-05</proposal_call><code>IP-2024-05-9904</code><acronim><![CDATA[ANEMIC PM]]></acronim><duration>16.12.2024 - 15.12.2027</duration><status>U tijeku</status><financ_value>199.931,25 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Temeljne tehničke znanosti, Brodogradnja, Građevinarstvo, Strojarstvo, Zrakoplovstvo, raketna i svemirska tehnika, </scie_field_hr><scie_field_en>Basic engineering sciences, Naval architecture, Civil engineering, Mechnical engineering, Aerospace, missile and space engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Građevinski fakultet u Rijeci]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Civil Engineering]]></institution_en><team_members_id>1014, 3167, 17756, 27510, </team_members_id><team_members_names><![CDATA[Dragan Ribarić, Edita Papa Dukić, Sara Grbčić Erdelj, Laura Grbac, ]]></team_members_names><keywords_hr><![CDATA[Cosseratov kontinuum, analitička rješenja, metoda konačnih elemenata, eksperimentalne metode, identifikacija parametara]]></keywords_hr><keywords_en><![CDATA[Cosserats&#39; continuum, analytical solutions, finite-element method, experimental methods, parameter identification]]></keywords_en><summary_hr><![CDATA[Cosseratova teorija kontinuuma generalizacija je klasične Cauchyjeve teorije, u kojoj momentno naprezanje postoji na razini čestice. Ta teorija može opisati određene eksperimentalno opažene pojave koje klasična teorija ne može i posebno je primjenjiva na prirodne i umjetno izrađene materijale s unutarnjom strukturom. Još uvijek nisu uspostavljene pouzdane eksperimentalne metode za određivanje parametara Cosseratovog materijala. Robusne numeričke procedure za identifikaciju Cosseratsovih parametara izvedene su u okviru HRZZ projekta FIMCOS, gdje su otvorena brojna istraživačka pitanja vezana uz Cosseratovu teoriju kontinuuma, koja će se istražiti u okviru predloženog projekta. Davanje odgovora na slijedeća pitanja predstavlja ciljeve našega projekta: (i) Može li se inverzni efekt veličine uzorka, pri čemu manji uzorci postaju mekši (a ne krući) od većih, ipak objasniti Cosseratovom teorijom kontinuuma? (ii) Mogu li se izvesti dodatna analitička rješenja za referentne probleme u linearnoj elastičnosti i koristiti za identifikaciju Cosseratovih parametara materijala? (iii) Mogu li se analitička rješenja za čisto savijanje pri velikoj zakrivljenosti u ravninskom stanju deformacija proširiti na više hiperelastičnih materijala (klasičnih i Cosseratovih) od trenutno poznatih i mogu li se koristiti za karakterizaciju takvih materijala? Problemima inverznog efekta veličine uzorka i čistog savijanja pri visokoj zakrivljenosti pristupit će se na inovativan način temeljen na zakonitostima međuovisnosti naprezanja/momentnih naprezanja i kinematike cirkularnog deformiranja, koja daje integrabilne diferencijalne jednadžbe problema. Ovo istraživanje pružit će teorijsku osnovu za projektiranje umjetnih materijala s unutarnjom strukturom za potrebe najsuvremenijih tehnologija. ]]></summary_hr><summary_en><![CDATA[Cosserats’ continuum theory is a generalisation of classical Cauchy’s theory, in which couple stresses exist at the particle level. It can describe certain experimentally observed phenomena, which the classical theory cannot and is particularly applicable to natural and man-made materials with internal structure. Reliable experimental methods to determine Cosserats&#39;material parameters are still not established. Robust numerical procedures for Cosserats&#39; parameter identification have been derived within the HRZZ project FIMCOS, where a number of research questions regarding Cosserats&#39; continuum theory have opened, which will be investigated within the research proposed. In particular, we will set our project objectives as an attempt to provide answers to these questions: (i) Can an &#39;inverse&#39; size effect, whereby smaller specimens tend to be softer (and not stiffer) than the larger ones, still be explained by Cosserat&#39;s continuum theory? (ii) Can additional analytical solutions for benchmark problems in linear elasticity be derived and made use of for identification of Cosserats&#39; material parameters? (iii) Can analytical solutions for large-curvature plain-strain pure bending be extended to a wider class of hyperelastic materials (both classical and Cosserats&#39;) than currently known and can they be used to characterise such materials? Inverse size effect and high-curvature pure bending results will be addressed in an innovative manner based on specific properties of stress/stress-couple interdependence and of circular-deformation kinematics providing integrable differential equations of the problem. This investigation will provide the theoretical background for the design of architected materials with exposed internal structure in cutting-edge developing techologies.]]></summary_en></project><project>
<id>16792</id><title_hr><![CDATA[Utjecaj plastifikatora i mikroplastike na reprodukcijsko zdravlje muškaraca]]></title_hr><title_en><![CDATA[Effects of exposure to plasticizers and microplastics on men&#39;s reproductive health]]></title_en><user_id>2649</user_id><user_firstLast_name>Blanka Tariba Lovaković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2024-05</proposal_call><code>IP-2024-05-8815</code><acronim><![CDATA[PlastRepRisk]]></acronim><duration>16.12.2024 - 15.12.2027</duration><status>U tijeku</status><financ_value>200.000,00 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo, Prirodne znanosti, </scie_area_hr><scie_area_en>Biomedicine and health sciences, Natural sciences, </scie_area_en><scie_field_hr>Interdisciplinarne prirodne znanosti, Kemija, Temeljne medicinske znanosti, Javno zdravstvo i zdravstvena zaštita, </scie_field_hr><scie_field_en>Interdisciplinary natural sciences, Chemistry, Basic Medical Sciences, Public health and health services, </scie_field_en><institution_hr><![CDATA[Institut za medicinska istraživanja i medicinu rada]]></institution_hr><institution_en><![CDATA[Institute for Medical Research and Occupational Health]]></institution_en><team_members_id>21444, 4161, 1490, 1376, 25491, 198, 12850, 868360, 872930, </team_members_id><team_members_names><![CDATA[Andreja Jurič, Irena Brčić Karačonji, Marija Dvoršćak, Darija Klinčić, Karla Jagić, Zorana Kljaković-Gašpić, Anja Katić, Dinko Hauptman, Lucija Kutleša, ]]></team_members_names><keywords_hr><![CDATA[plastifikatori, mikroplastika, razvoj metode, reprodukcija, biomonitoring]]></keywords_hr><keywords_en><![CDATA[plasticizers, microplastics, method development, reproduction, biomonitoring]]></keywords_en><summary_hr><![CDATA[Uz dobro poznate ftalatne estere (PAE), organofosfatni esteri (OPE) slabije su istražena klasa plastifikatora koji se zbog svojih svojstava dodaju u brojne uporabne proizvode te su široko rasprostranjeni u okolišu. Sveprisutno su otkriveni u urinu odraslih i djece u općoj populaciji zbog čega privlače sve veću pozornost znanstvene zajednice i regulatornih tijela zaduženih za zaštitu i očuvanje okoliša i zdravlja ljudi. Osim toga, globalni porast upotrebe jednokratnih plastičnih proizvoda izazvao je golem porast izloženosti ljudi mikroplastici (MP). Jedan od glavnih ciljeva projekta PlastRepRisk je uspostaviti analitičku platformu za određivanje plastifikatora (OPE, PAE) i čestica MP u složenim uzorcima ljudske krvi (seruma) i urina kako bi dobili prve podatke o razinama izloženosti opće populacije u Hrvatskoj spojevima OPE i PAE te česticama MP. Iako njihovi učinci na zdravlje još nisu u potpunosti razjašnjeni, za pojedine spojeve OPE i PAE te MP postoji sumnja da djeluju kao endokrini disruptori i/ili štetno utječu na reprodukcijsko zdravlje. U ovom istraživanju ispitat će se i rizici za muško reprodukcijsko zdravlje usporedbom ispitanika s dijagnozom neplodnosti i kontrolnih (zdravih) ispitanika. Kako bismo istražili hipotezu da izloženost spojevima OPE i PAE, te česticama MP može nepovoljno utjecati na plodnost, ispitat će se korelacije između koncentracija odabranih spojeva OPE i PAE te MP u krvi/urinu i neplodnosti koju karakterizira mali broj i/ili loša kvaliteta spermija i poremećaj u razinama spolnih hormona. Osim prvih podataka o razinama izloženosti hrvatske populacije (muškaraca reproduktivne dobi) spojevima OPE i PAE te MP, istraživanje će dati ključna saznanja o njihovom mogućem utjecaju na poremećaj reprodukcijskog zdravlja u uvjetima stvarnih razina izloženosti.]]></summary_hr><summary_en><![CDATA[Along with the well-known phthalate esters (PAE), organophosphate esters (OPE) are a less researched class of plasticizers. Due to their properties, they are frequently added to consumer products, which is the main reason of the compounds&#39; widespread migration in the environment. The detection of PAEs and OPEs in the urine of the general public (both children and adults) has drawn the attention of scientists and regulatory agencies responsible for protection of human health and environment. Furthermore, the global rise in the use of disposable plastic items has led to an escalation in human contact with microplastics (MP). One of the main objectives of the PlastRepRisk project is to establish an analytical platform for analyzing plasticizers (OPE, PAE) and MP particles in complex matrices such as human blood serum and urine. Main goal is to obtain preliminary data on the levels of exposure of the general population in Croatia to OPE and PAE compounds and MP particles. Although their health effects have not yet been fully elucidated, certain OPE and PAE compounds, as well as MPs, are suspected to act as endocrine disruptors and/or have detrimental effects on reproductive health. This study will also evaluate the risks to male reproductive health by comparing men diagnosed with infertility to healthy (control) subjects. Correlations between the concentrations of specific OPE, PAE, and MPs in blood/urine and infertility defined as a low count and/or poor quality of sperm and disruption in sex hormone levels will be assessed in order to investigate the hypothesis that exposure to plasticizers/MP may adversely affect reproductive function. The research will provide key insights into the possible impact of OPE, PAE, and MPs exposure on reproductive health disorders under actual exposure levels, in addition to obtaining first data on the levels of exposure of the Croatian population (men of reproductive age) to these compounds/particles.]]></summary_en></project><project>
<id>16803</id><title_hr><![CDATA[Dvostruka nevolja: Virusna infekcija u kontekstu bolesti steatotične jetre povezane s metaboličkom disfunkcijom]]></title_hr><title_en><![CDATA[Double trouble: Viral infection in context of metabolic dysfunction-associated steatotic liver disease]]></title_en><user_id>7082</user_id><user_firstLast_name>Bojan Polić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2024-05</proposal_call><code>IP-2024-05-9583</code><acronim><![CDATA[VICES]]></acronim><duration>16.12.2024 - 15.12.2027</duration><status>U tijeku</status><financ_value>199.850,00 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Medicine]]></institution_en><team_members_id>856077, 861539, 873094, </team_members_id><team_members_names><![CDATA[Sanja Mikašinović, Sali Slavić Stupac, Lara Melvan, ]]></team_members_names><keywords_hr><![CDATA[MASLD, MCMV, LCMV, IAV, stanice NK, stanice ILC, limfociti T, makrofagi]]></keywords_hr><keywords_en><![CDATA[MASLD, MCMV, LCMV, IAV, NK cells, ILCs, T cells, Macophages]]></keywords_en><summary_hr><![CDATA[Bolest masne jetre povezana s metaboličkom disfunkcijom (MASLD) smatra se jetrenom manifestacijom metaboličkog sindroma i pogađa gotovo polovicu svjetske odrasle populacije. MASLD obuhvaća niz kliničkih entiteta u rasponu od jednostavne steatoze do ciroze. MASLD je povezan s više poznatih komorbiditeta, no imunološka disfunkcija je i dalje slabo istražena. Epidemiološki podaci pokazuju da osobe s MASLD-om imaju znatno povećanu vjerojatnost obolijevanja  i smrtnosti od zaraznih bolesti, no osnovni mehanizam u pozadini istog je uglavnom nepoznat. Nedavno je moj tim pokazao da je ključni događaj u patofiziologiji MASLD-a razvoj imunosnog odgovora, obilježenog citokinom IL-17A, koji uzrokuje polariziranu upalu tipa 3 koja dovodi do fibroze jetre. Naši preliminarni nalazi pokazuju da upalno mikrookruženje u jetri uzrokovano MASLD-om narušava imunosni odgovor tipa 1 prilikom virusnih infekcija, što rezultira većom količinom virusnih čestica nakon infekcije. Glavni cilj ovoga projekta jest razjasniti kako MASLD remeti antivirusni imunosni odgovor. Korištenje mišjeg modela za MASLD razvijenog u mom laboratoriju razjasnit ćemo koja je faza antivirusnog imunosnog odgovora i koliko široko pogođena. Uz pomoć genetski modificiranih mišjih modela identificirat ćemo koji čimbenik izazvan MASLD-om posreduje ovaj učinak i koje su antivirusne imunološke stanice prvenstveno pogođene ovom metaboličkom bolešću. Koristit ćemo molekularno-biološke tehnike kako bismo okarakterizirati ključne unutarstanične čimbenike u imunosnim stanicama na koje utječe MASLD. Očekujemo da će ovaj projekt omogućiti dublje razumijevanje štetnog učinka koji MASLD ima na normalan antivirusni imunosni odgovor. S obzirom na vrlo visoku učestalosti MASLD-a u populaciji, naša otkrića bi mogla imati veliki utjecaj na buduće strategije u pogledu prevencije i liječenja zaraznih bolesti.]]></summary_hr><summary_en><![CDATA[MASLD comprises a range of clinical entities, ranging from simple steatosis to cirrhosis. MASLD is associated with several comorbidities, but immune disfunction has remained largely ignored. Epidemiological data indicates that people with MASLD have a strongly increased chance of morbidity and mortality because of infectious disease, but the underlying mechanism is unknown. Recently, my team has shown that a key event in the pathophysiology of MASLD is the development of an immune response, marked by the cytokine IL-17A, which causes a type-3 polarized inflammation that leads to liver fibrosis. Our preliminary findings indicate that the inflammatory microenvironment in the liver caused by MASLD impairs the type-1 immune response to viruses, leading to higher pathogen loads upon infection. The goal of this project is to elucidate how MASLD impairs the antiviral immune response. Using a dietary animal model for MASLD developed in my lab, we will elucidate which phase of the antiviral immune response is affected and how broadly the response is impacted. With advanced genetic models, we will identify which MASLD-induced factor mediates this effect and which antiviral immune cell is primarily impacted by this metabolic disease. Molecular biological techniques will be used to characterize the key intracellular factors affected by MASLD-induced inflammation in these immune cells. Thus, this project will provide deeper understanding of the detrimental effect that MASLD has on the normal antiviral immune response. Considering the frighteningly high incidence of MASLD in our society, our findings have great implications for future strategies with regards to prevention and treatment of infectious disease.]]></summary_en></project><project>
<id>16811</id><title_hr><![CDATA[Sekvencijalno molekularno i elementno mapiranje korištenjem MeV SIMS-a i drugih IBA tehnika]]></title_hr><title_en><![CDATA[Sequential molecular and elemental imaging using MeV SIMS and other IBA techniques]]></title_en><user_id>2755</user_id><user_firstLast_name>Ivančica Bogdanović Radović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2024-05</proposal_call><code>IP-2024-05-8924</code><acronim><![CDATA[SIMSIBA]]></acronim><duration>16.12.2024 - 15.12.2027</duration><status>U tijeku</status><financ_value>199.220,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, Kemija, Biologija, </scie_field_hr><scie_field_en>Physics, Chemistry, Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>4670, 5072, 12693, 3410, 868063, 855413, 867944, 867981, 867980, 25285, </team_members_id><team_members_names><![CDATA[Zdravko Siketić, Matea Krmpotić, Tanja Matijević Glavan, Marijana  Popović Hadžija, Dubravka Jembrih-Simbuerger, Andrea Ledic, Jasna Galeković, Stjepan Brzica, Veronika Marinović, Marko Brajković, ]]></team_members_names><keywords_hr><![CDATA[MeV SIMS, PIXE, IBA metode, sekvencionalno elementno i molekularno mapiranje, ionski izvor za čišćenje i rasprašivanje, udarni presjeci za oštećenje]]></keywords_hr><keywords_en><![CDATA[MeV SIMS, PIXE, IBA techniques, sequential elemental and molecular imaging, ion source, ion gun for cleaning and sputtering, damage cross sections]]></keywords_en><summary_hr><![CDATA[U ovom projektu cilj je sekvencionalno povezati metode za analizu pomoću ionskih snopiva (IBA metoda) koje služe za određivanje 2D distribucije elemenata kao što su česticama inducirana emisija X-zračenja (PIXE) i Rutherfordovo elastično raspršenje unatrag (RBS), s MeV SIMS-om koji daje informaciju o molekularnom sastavu uzorka s ciljem dobivanja potpune, korelirane informacije o elementnom i molekularnom sastavu. Istraživanja mogućnosti kolreliranog određivanja prostorne molekulske i elementne distribucije u posljednje je vrijeme u fokusu mnogih istraživačkih grupa u svijetu a interes za to postoji u raznim područjima, od biomedicine do forenzike i čuvanja kulturne baštine. Tako u biomedicini, elementni i molekularni markeri igraju važnu ulogu u razumijevanju i praćenju napredovanja bolesti. Kolokacija biomarkera u tkivima može dovesti do boljeg razvoja novih terapija i ljekova. Kombinacija površinske MeV SIMS i dubinske PIXE metode može otkriti redosljed depozicije kemijskih i tonera na dokumentima koji su predmet forenzičkog istraživanja. U forenzici danas za to ne postoje metode koje bi to mogle pouzdano napraviti. Također, karakterizacija i kolokacija organskih i anorganskih komponenti u slikarskim materijalima i slikama može pomoći u određivanju porijekla umjetnina te njihovoj restauraciji. Da bi se moglo mapirati površine uzorka koje nisu kontaminirane raznim onečišćenjima, planira se instalirati ionski izvor za čišćenje i rasprašivanje. Također, izmjerit će se udarni presjeci za oštećenje kako bi se procjenila razina oštećenja uzoraka tijekom mjerenja. Također, za razne vrste organiskh uzoraka, odredit će se optimalan ionski snop za sekvencionalna MeV SIMS-PIXE mjerenja.]]></summary_hr><summary_en><![CDATA[In this project, ion beam analysis (IBA) methods used to determine the 2D distribution of elements, such as particle-induced X-ray emission (PIXE) and Rutherford elastic backscattering (RBS), will be sequentially linked to MeV-SIMS, which provides information on the molecular composition of the sample, in order to obtain complete, correlated information on elemental and molecular composition. Exploring the possibility of correlated determination of spatial molecular and elemental distribution has recently been the focus of interest of numerous research groups around the world, in various fields ranging from biomedicine to forensics and cultural heritage preservation. In biomedicine, elemental and molecular markers play an important role in understanding and monitoring disease progression. The detection of biomarkers in tissues can lead to better development of new therapies and drugs. The combination of surface sensitive MeV SIMS technique and PIXE method that provides information from deeper layers of the sample, can reveal the sequence of deposition of writing tools on documents that are the subject of forensic investigations. There are currently no methods in forensics that can do this reliably. The characterisation and classification of organic and inorganic components in painting materials and paintings can also help to determine the origin of a work of art and its restoration. The advantages of sequential elemental and molecular mapping are numerous and subject of investigation in this project. In order to be able to map sample surfaces that are not contaminated by various contaminants, it is planned to install an ion source for cleaning and sputtering. Also, damage cross sections will be measured to assess the level of sample damage during the measurement. Also, for various types of organic samples, the optimal ion beam for sequential MeV SIMS-PIXE measurements will be determined.]]></summary_en></project><project>
<id>16815</id><title_hr><![CDATA[Kvantna memorija za pojedinačne fotone u optičkoj šupljini s membranom u sredini]]></title_hr><title_en><![CDATA[Membrane-in-the-middle quantum memory for single photons]]></title_en><user_id>5714</user_id><user_firstLast_name>Nenad Kralj</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2024-05</proposal_call><code>IP-2024-05-5670</code><acronim><![CDATA[MIMIQ.ME]]></acronim><duration>20.12.2024 - 19.12.2027</duration><status>U tijeku</status><financ_value>199.760,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci]]></institution_hr><institution_en><![CDATA[University of Rijeka]]></institution_en><team_members_id>1037, 24455, 22599, 873083, 874042, </team_members_id><team_members_names><![CDATA[Marin Karuza, Ivor Krešić, Neven Šantić, Lucija Črep, Paritosh Verma, ]]></team_members_names><keywords_hr><![CDATA[optomehanika, optička šupljina, šupljina s membranom u sredini, kvantna memorija, pojedinačni fotoni,]]></keywords_hr><keywords_en><![CDATA[optomechanics, optial cavity, membrane-in-the-middle cavity, quantum memory, single photons]]></keywords_en><summary_hr><![CDATA[Mnoge primjene kvantne teorije, poput kvantne kriptografije na velikim udaljenostima i međusobnog povezivanja kvantnih računala, zahtijevaju distribuciju kvantnih resursa, kao što je sprezanje. Pridruženi gubici uvjetuju potrebu za kvantnim ponavljačima, čija je ključna sastavnica kvantna memorija. Predloženi su različiti protokoli za takve memorije, ali postojeće realizacije ne uspijevaju obuhvatiti sljedeća željena svojstva u jednom sustavu: dugo vrijeme koherencije, visoka učinkovitost, očitavanje na zahtjev i kompatibilnost s C-pojasom telekomunikacija. U MIMIQ.ME, radit ćemo na razvoju memorijske platforme za pojedinačne fotone (SP) temeljene na principu optomehanički inducirane prozirnosti (OMIT), koja može funkcionirati na raznim valnim duljinama te, zajedno s odgovarajućim SP izvorom, ispuniti sve ove zahtjeve. Memorijom ćemo upravljati na sobnoj temperaturi i implementirati ju u određenom optomehaničkom sustavu, šupljini s membranom u sredini (MIM), gdje se SP-ovi pohranjuju u vibracijskom modu ultrakoherentnog meko stegnutog membranskog rezonatora. Testirat ćemo platformu pomoću optičkih pulseva, postižući rekordna vremena pohrane i učinkovitosti među optomehaničkim memorijama.Realizirat ćemo izvor najavljenih SP-ova za pohranjivanje, na temelju spontane parametarske konverzije prema dolje u nelinearnom kristalu. Rezonantno ćemo pojačati proces postavljanjem kristala u drugu optičku šupljinu kako bismo formirali optički parametarski oscilator. Nakon MIMIQ.ME, planiramo mjeriti očuvanje sprezanja između generiranih parova fotona nakon pohrane kako bismo potvrdili da sustav radi kao kvantna memorija. Gledajući dalje, on se može koristiti za pohranjivanje polarizacijskih kubita koje generiraju SP-ovi na zahtjev iz poluvodičkih kvantnih točaka, čime bi se stanje kvantnih mreža pogurnulo prema praktičnim primjenama. Koliko platforma obećava pokazuje i činjenica da pojedini MIM sustavi s meko stegnutim membranama rade u kvantnom režimu već na sobnoj temperaturi.]]></summary_hr><summary_en><![CDATA[Many applications of the quantum theory, like quantum cryptography over long distances and interconnection of quantum computers, require the distribution of quantum resources, such as entanglement. Associated losses dictate the need for quantum repeaters, a key facilitator in which is a quantum memory. Different protocols for such memories have been proposed, but existing realizations fall short of combining the following desired properties in a single system: long coherence time, high efficiency, on-demand readout and compatibility with the telecom C-band. In MIMIQ.ME, we will work on the development of a wavelength-versatile memory platform for single photons (SPs) based on the principle of optomechanically induced transparency (OMIT), which can be used in conjunction with a suitable SP source to fulfil all of these requirements. We will operate the memory at room temperature and implement it in a particular optomechanical system, the membrane-in-the-middle (MIM) cavity, where the SPs are stored in a vibrational mode of an ultracoherent soft-clamped membrane resonator. We will test the platform using optical pulses, showcasing record storage times and efficiencies among optomechanical memories.We will realize a source of heralded SPs to be stored, based on spontaneous parametric down conversion in a nonlinear crystal. We will resonantly enhance the process by placing the crystal inside another cavity to form an optical parametric oscillator. Following MIMIQ.ME, we plant to measure the preservation of entanglement between generated photon pairs after storage to confirm the system works as a quantum memory. Looking further ahead, it can be used to store polarization qubits generated by on-demand SPs from semiconductor quantum dots, propelling the state of the art of quantum networks towards practical applications. This promise is further highlighted by the fact that MIM systems with soft-clamped membranes have seen room-temperature operation in the quantum regime.]]></summary_en></project><project>
<id>16816</id><title_hr><![CDATA[Sintetički projektni hidrogrami u uvjetima sadašnje i buduće klime za procjenu lokalnog podlokavanja oko mostova]]></title_hr><title_en><![CDATA[Synthetic design hydrographs under current and future climate for local bridge scour assessment]]></title_en><user_id>20384</user_id><user_firstLast_name>Kristina Potočki</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2024-05</proposal_call><code>IP-2024-05-1497</code><acronim><![CDATA[SERIOUS]]></acronim><duration>09.12.2024 - 08.12.2027</duration><status>U tijeku</status><financ_value>148.392,89 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Građevinarstvo, Interdisciplinarne tehničke znanosti, </scie_field_hr><scie_field_en>Civil engineering, Interdisciplinary technological sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Građevinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Civil Engineering]]></institution_en><team_members_id>3529, 856175, 868327, 868399, 867551, 866747, 872969, 874052, </team_members_id><team_members_names><![CDATA[Damir Pintar, Martina Lacko, Nejc Bezak, Tobias Conradt, Damir Bekić, Marko Šrajbek, Fran Vuić, Anandharuban Panchanathan, ]]></team_members_names><keywords_hr><![CDATA[sintetički projektni hidrogrami, hidrološko modeliranje, klimatske promjene, podlokavanje, most]]></keywords_hr><keywords_en><![CDATA[synthetic design hydrographs, hydrologic modelling, climate change, scour, bridge]]></keywords_en><summary_hr><![CDATA[Cilj SERIOUS projekta je odgovoriti na istraživačko pitanje je li moguće generirati sintetičke projektne hidrograme (SPH) na temelju statističke bivarijantne analize poplavnih događaja pod sadašnjim i budućim klimatskim uvjetima u kontinentalnom dijelu Hrvatske (dio sliva Dunava) te njihova primjena u procjeni utjecaja klimatskih promjena na podlokavanje oko mostova na odabranim pilot lokacijama. Klimatske promjene dovode do intenzivnijih poplavnih događaja čime se bitno mijenjaju morfodinamički uvjeti u riječnom koritu, što dovodi do narušavanja stabilnosti građevina smještenih u vodotoku, a posebice mostova. U dosadašnjim istraživanjima uočena je potreba za unapređenjima u metodološkom pristupu u svrhu smanjenja neizvjesnosti prilikom modeliranja utjecaja klimatskih promjena, hidrološkog modeliranja i modeliranja lokalnog podlokavanja oko stupova mosta. Unutar projekta bit će uspostavljen metodološki okvir za određivanje kontrolnog SPH na temelju pregleda literature i dostupnih podataka na odabranim pilot područjima u Hrvatskoj, gdje će se koristiti algoritmi nadziranog i/ili nenadziranog strojnog učenja za određivanje različitih tipova SPH na temelju različitih oblika i topologija. Koristit će se hidrološki model s projekcijama klimatskih promjena iz CMIP5 ili CMIP6 kako bi se odredile promjene u SPH. Cilj je metodološki povezati klimatske promjene s lokalnim podlokavanjem razvijanjem metodologije za procjenu utjecaja klimatskih promjena na karakteristike poplavnih valova, proračunavanjem lokalnog podlokavanja oko stupova mostova na toj osnovi i usporedbom pouzdanosti dobivenih rezultata s izmjerenim vrijednostima. Rezultati projekta koristit će stručnjacima u području hidrauličnog i riječnog inženjerstva, javnim tijelima koja upravljaju prometnom infrastrukturom i mostovima, kao i hidrološkoj praksi u Hrvatskoj, kroz poboljšanu metodologiju za određivanje SPH, koji služe kao ulazni podatak za projektiranje različitih hidrotehničkih građevina.]]></summary_hr><summary_en><![CDATA[The aim of the SERIOUS project is to answer the research question whether it is possible to establish synthetic design hydrographs (SDH) based on a statistical bivariate analysis of flood events under the current and future climate in the continental part of Croatia (part of the Danube River Basin) and apply them for the assessment of climate change impacts on bridge scour at the selected pilot sites. Climate change leads to more intense flood events, which significantly change the morphodynamic conditions in rivers and thus jeopardize the stability of structures in the watercourse, especially bridges. Previous research has shown that methodological approaches need to be improved to reduce uncertainties in modelling the effects of climate change, hydrological modelling and modelling of local scour around bridge piers. Within the project, methodological framework for determining control synthetic design hydrograph based on the literature review and available data in selected pilot areas in Croatia will be established, where algorithms of supervised and/or unsupervised machine learning will be used to determine the different SDH types based on the different shapes and topologies. Hydrological model with climate change projections from the CMIP5 or CMIP6 will be used to estimate changes in SDH. The aim is to methodologically link climate change to local scour by developing a methodology to assess the influence of climate change on flood wave characteristics, calculating local scour around bridge piers on this basis and comparing the reliability of the obtained results with measured values. The project results will benefit hydraulic and river engineering experts, public entities managing transportation infrastructure and bridges, as well as hydrological practices in Croatia through an improved methodology for determining SDH, which serves as input data for the design of various water engineering structures.]]></summary_en></project><project>
<id>16823</id><title_hr><![CDATA[Napredni modeli dinamičkih energijskih budžeta s transportnom mrežom]]></title_hr><title_en><![CDATA[Advanced Dynamic Energy Budget Models with Transport Networks]]></title_en><user_id>5520</user_id><user_firstLast_name>Tin Klanjscek</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2024-05</proposal_call><code>IP-2024-05-3615</code><acronim><![CDATA[AdvanDEB]]></acronim><duration>20.12.2024 - 19.12.2027</duration><status>U tijeku</status><financ_value>199.657,50 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Interdisciplinarne prirodne znanosti, Matematika, Fizika, Kemija, Biologija, </scie_field_hr><scie_field_en>Interdisciplinary natural sciences, Mathematics, Physics, Chemistry, Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>868181, 20457, 867890, 7332, 23207, 7566, 20466, 872359, 873014, </team_members_id><team_members_names><![CDATA[Roger Nisbet, Lav Bavčević, Andreja Radovic, Tomislav Matić, Ines Haberle, Ivan Aleksi, Marko Jusup, Domagoj Hackenberger Kutuzović, Ivana Terzić, ]]></team_members_names><keywords_hr><![CDATA[bioenergetika, Dinamički Energijski Budžeti (DEB), ekotoksikologija, fiziološko modeliranje, Umjetne neuronske mreže ]]></keywords_hr><keywords_en><![CDATA[bioenergetics, Dynamic Energy Budgets (DEB), ecotoxicology, mechanistic physiological modeling, artificial neural networks (ANN)]]></keywords_en><summary_hr><![CDATA[Modeli dinamičkih energijskih budžeta (DEB) kvantitativni su alat koji opisuje akviziciju i alokaciju energije u organizmima, te tako omogućuju povezivanje više okolišnih i bioloških razina. Stoga su često bili ključni u rješavanju važnih društvenih problema od proizvodnje hrane, zaštite biodiverziteta i ekosustava, korištenja resursa, do učinaka zagađivala na organizme. Moderni DEB modeli preuzetu energiju trenutačno pohranjuju u rezerve, koju pomoću &#39;&#39;k-pravila&#39;&#39; raspodjeljuje u stalnom omjeru reprodukciji i drugim procesima. Takvi DEB modeli dobro simuliraju učinke dugoročnih procesa ali nisu adekvatni za modeliranje kratkoročnih, te ne povezuju vjerodostojno varijable stanja s fiziologijom organizama. Uključivanjem transportne mreže kao što je krvotok u model mogu se otkloniti ti nedostaci. Iako je uspješnom primjenom transportne mreže na kita i indikacija da je primjenjiva na ribe pokazala visok potencijal široke njihove primjene, preostala su mnoga neriješena pitanja koja onemogućavaju široku primjenu i prihvaćanje DEB modela temeljenih na transportnim mrežama (tDEB). Projekt AdvanDEB dat će odgovore na ta ključna pitanja (i) provjerom i osiguranjem dosljednosti s poznatim biološkim principima, (ii) definiranjem jasnih pravila za korištenje energije tijekom reprodukcije, (iii) testiranjem općenitosti i definiranjem primjenjivosti tDEB-a, (iv) analizom odnosa između tDEB-a i drugih teorija i (v) razvijanjem formalnog skupa pretpostavki i jedinstvene terminologije.AdvanDEB će iskoristiti postojeće resurse kao što je AmP baza podataka DEB zajednice od 4500 vrsta, te konvencionalnim metodama i metodama potpomognutima umjetnom inteligencijom identificirati domene primjenjivosti za tDEB, istražiti općenitosti unutar i između filogenetskih skupina, te formalizirati tDEB teoriju. Dodatno, AdvanDEB može ujediniti DEB teoriju s Metaboličkom teorijom ekologije, čime stvara potencijal za promjenu paradigme u bioenergetici i otvara nove puteve istraživanja.]]></summary_hr><summary_en><![CDATA[Dynamic Energy Budget (DEB) models describe acquisition and utilization of energy in organisms, and have been instrumental in connecting scales of biological integration to solve a number of existing and emerging societal issues such as optimizing food production, improving conservation, optimizing resource use, and understanding effects of pollutants. Currently, DEB models assume acquired energy is immediately stored in the organism, and utilize the kappa-rule to partition energy between reproduction and other processes. The k-rule DEB (kDEB) models excel at capturing long-term effects, but struggle with short-term changes and linking to organism physiology.Integration of a transport network, such as blood, holds promise for overcoming these limitations. A study on marine mammals and an initial study on fish model that incorporates such a network suggest these transport-based DEB models could be widely applicable. While these models hold promise, key challenges to their wide adoption need to be addressed.AdvanDEB project tackles these key challenges: (i) ensuring consistency with established biological principles, (ii) defining clear rules for energy use during reproduction, (iii) testing generality and defining applicability of tDEB, (iv) analyzing relationships between tDEB and other theories, and (v) developing a formal set of assumptions and a unified terminology. AdvanDEB will leverage existing resources like the DEB community&#39;s AmP database of 4500 species, conventional analysis, and artificial-neural-network approaches to identify domain of applicability for tDEB, investigate within- and between-phylum generality, and formalize the tDEB theory. Additionally, AdvanDEB may unify DEB theory with the Metabolic Theory of Ecology, thus potentially inducing a paradigm shift in bioenergetics, and opening new avenues of research.]]></summary_en></project><project>
<id>16825</id><title_hr><![CDATA[Metrička svojstva grafova]]></title_hr><title_en><![CDATA[Metric properties of Graphs]]></title_en><user_id>26632</user_id><user_firstLast_name>Snježana Majstorović Ergotić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2024-05</proposal_call><code>IP-2024-05-2130</code><acronim><![CDATA[MetGraph]]></acronim><duration>16.12.2024 - 15.12.2027</duration><status>U tijeku</status><financ_value>163.840,28 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Fakultet primijenjene matematike i informatike]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, School of Applied Mathematics and Informatics]]></institution_en><team_members_id>5636, 867951, 867915, 5545, 865392, 867937, 867900, 872877, </team_members_id><team_members_names><![CDATA[Tomislav Došlić, Dragan Stevanović, Riste ŠKREKOVSKI, Jelena Sedlar, Luka Podrug, Tobias Hofmann, Kurt Klement Gottwald, Robert Ledenčan, ]]></team_members_names><keywords_hr><![CDATA[Grafovska metrika, metrička svojstva, Šoltésov problem, metrička dimenzija, metalne kocke, Horadamove kocke, Horadam-Lucasove kocke]]></keywords_hr><keywords_en><![CDATA[Graph metric, metric properties, Šoltés problem, metric dimension, metallic cubes, Horadam cubes, Horadam-Lucas cubes]]></keywords_en><summary_hr><![CDATA[Grafovske metrike i njihova proširenja iznimno su važni za razumijevanje strukturnih svojstava kompleksnih mreža. Primjerice, ako koristimo graf za modeliranje računalne mreže, onda udaljenost između njegovih vrhova predstavlja vrijeme potrebno za međusobnu komunikaciju odgovarajućih procesora. Ovaj koncept je koristan pri procjeni statistike vremena povezane s distribuiranim računarstvom. Za istraživanje i predviđanje korelacije struktura-svojstvo organskih spojeva u kemiji, potrebno je razumjeti međuatomske udaljenosti u pridruženom molekularnom grafu.Cilj ovog projekta je analiza metričkih svojstava grafova, posebno proučavanje problema temeljenih na udaljenostima među vrhovima u kontekstu različitih grafovskih metrika, njihovih poopćenja i proširenja. Jedan smjer istraživanja odnosi se na proučavanje Šoltesovih problema na grafovima vezanih uz poznate grafovske metrike te s udaljenosti toka, koja je neistražena grafovska ultrametrika. U takvim problemima će biti istražena osjetljivost grafovskih invarijanti, poput Wienerova indeksa, Kirchhoffova indeksa, indeksa toka i k-tog Steiner-Wienerova indeksa na male promjene u grafu. Slična istraživanja bit će provedena na usmjerenim grafovima uzimajući u obzir različite digrafovske metrike i njihova proširenja. Potencijalna primjena ovakvih istraživanja je u problemima otpornosti kompleksnih mreža. Drugi smjer istraživanja odnosi se na metričku dimenziju grafa, invarijantu koja se danas uglavnom koristi u raznim vrstama kompleksnih mreža te u robotici. Bit će istraženi problemi vezani uz različite vrste metričkih dimenzija te će biti razvijen heuristički algoritam za računanje metričke dimenzije grafa. Bit će istražena i veza između metričke dimenzije i spektra razdaljinske Laplaceove matrice. Nadalje, analizirat će se strukturna i metrička svojstva metalnih, Horadamovih te Horadam-Lucasovih kocaka, koje su nedavno uvedene familije grafova.]]></summary_hr><summary_en><![CDATA[Graph metrics and their extensions are of great importance for understanding the structural properties of complex networks. For example, if a graph is being used to model a computer network, the distance between vertices represents the time required for the corresponding processors to communicate with each other. This concept is useful when estimating timing statistics associated with distributed computing. In chemistry, to investigate and predict the structure-property correlation of organic compounds, one must understand the interatomic distances in the associated molecular graph. The goal of this project is the analysis of metric properties of graphs, in particular the study of distance-based problems on graphs in the context of different graph metrics, their generalizations and extensions. One research direction includes the study of Šoltés problems on graphs related to the well-known graph metrics and flow distance, an unexplored graph ultrametric. In these problems, the sensitivity of graph invariants such as the Wiener index, the Kirchhoff index, the flow index, and the k-th Steiner Wiener index to small changes in a graph is investigated. Similar studies will be conducted on digraphs by considering various digraph metrics and their extensions. Possible applications of these studies lie in the investigation of the resilience of complex networks.Another line of research focuses on the metric dimension of a graph, an invariant that is nowadays mainly used in various types of complex networks and robotics. Problems related to the different types of metric dimensions will be investigated and a heuristic algorithm for computing the metric dimension will be developed. The connection between the metric dimension and the spectrum of distance Laplacian matrix will be explored.Furthermore, the structural and metric properties of metallic, Horadam, and Horadam-Lucas cubes, recently introduced families of graphs will be analyzed. ]]></summary_en></project><project>
<id>16827</id><title_hr><![CDATA[Specifični bioaktivni metaboliti postbiotika i probiotika proizvedeni primjenom nusproizvoda mliječne industrije]]></title_hr><title_en><![CDATA[Specific bioactive metabolites of postbiotics and probiotics produced using by-products of the dairy industry]]></title_en><user_id>798</user_id><user_firstLast_name>Blaženka Kos</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2024-05</proposal_call><code>IP-2024-05-6548</code><acronim><![CDATA[POST-BIO]]></acronim><duration>09.12.2024 - 08.12.2027</duration><status>U tijeku</status><financ_value>194.750,00 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Biotehnologija, Interdisciplinarne biotehničke znanosti, </scie_field_hr><scie_field_en>Biotechnology, Interdisciplinary biotechnical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Food Technology and Biotechnology]]></institution_en><team_members_id>796, 797, 799, 18967, 21384, 4314, 1052, 868036, 3005, 3319, 23410, 868035, 857311, </team_members_id><team_members_names><![CDATA[Jasna Beganović (udana Novak), Andreja Leboš Pavunc, Jagoda Šušković, Martina Banić, Katarina Butorac, Anita Slavica, Ana Butorac, Maria Michela Corsaro, Ana  Savić Mlakar, Nada Oršolić, Dyana Odeh, Angela Casillo, Mia Radović, ]]></team_members_names><keywords_hr><![CDATA[postbiotici, probiotici, crijevna mikrobiota, permeat mlijeka, sirutka, bioaktivni peptidi, egzopolisaharidi, bakteriocini, S-proteini, inkapsulacija]]></keywords_hr><keywords_en><![CDATA[postbiotics, probiotics, intestinal microbiota, milk permeate, whey, bioactive peptides, exopolysaccharides, bacteriocins, S-proteins, encapsulation]]></keywords_en><summary_hr><![CDATA[Postbiotici, kao jedan od novijih znanstvenih pristupa unutar probiotičkog koncepta, za razliku od probiotika, sadrže inaktivirane mikrobne stanice i njihove bioaktivne metabolite, sa zadržanim probiotičkim svojstvima. Stoga će se provesti optimiranje procesnih parametara proizvodnje postbiotika primjenom inovativne procesne tehnologije pulsirajućeg električnog polja, termičke obrade i lizozima. Za proizvodnju postbiotika bit će odabrani autohtoni sojevi bakterija mliječne kiseline (BMK) izolirani iz majčinog mlijeka i tradicionalno proizvedenih fermentiranih proizvoda, sa specifičnim svojstvom proizvodnje potencijalnih bioaktivnih metabolita: S-proteina, egzopolisaharida, bakteriocina i bioaktivnih peptida, sa svojim proteolitičkim enzimima. Bit će razvijeni novi funkcionalni proizvodi s postbioticima i probioticima, uz iskorištavanje nusproizvoda mliječne industrije kao što su permeat mlijeka i sirutka, za njihov uzgoj, inkapsulaciju i proizvodnju suhih bioaktivnih pripravaka. Provest će se usporedba funkcionalnih svojstava postbiotika i probiotika in vitro istraživanjima njihove antimikrobne, antioksidativne i proteolitičke aktivnosti, kao i ex vivo eksperimentima imunomodulacijskog djelovanja, adhezijskih svojstava i kompetitivne ekskluzije potencijalnih patogena na humanim staničnim linijama. Bit će također ispitani njihovi in vivo učinci na crijevnu mikrobiotu, imunost i metabolizam miševa s izazvanim dijabetesom. Stoga će istraživanja funkcionalnih učinaka živih i inaktiviranih mikrobnih stanica BMK i njihovih potencijalnih bioaktivnih metabolita doprinijeti razvoju novih pripravaka postbiotika i probiotika, u tekućoj i praškastoj inkapsuliranoj formi, uz prednost ekonomičnije proizvodnje korištenjem nusproizvoda mliječne industrije i veće stabilnosti postbiotika u odnosu na probiotike koji moraju sadržavati velik broj živih mikrobnih stanica.]]></summary_hr><summary_en><![CDATA[Postbiotics, as one of the newer scientific approaches within the probiotic concept, unlike probiotics, contain inactivated microbial cells and their bioactive metabolites, with retained probiotic properties. Therefore, the process parameters for the production of postbiotics will be optimised using the innovative process technology of pulsed electric fields, thermal treatment and lysozyme. For the production of postbiotics, autochthonous strains of lactic acid bacteria (LAB) isolated from mother&#39;s milk and traditionally produced fermented products will be selected on the basis of the specific property of producing potentially bioactive metabolites: S-proteins, exopolysaccharides, bacteriocins and bioactive peptides with their proteolytic enzymes. New functional products with postbiotics and probiotics will be developed using by-products of the dairy industry, such as milk permeate and whey, for their cultivation, encapsulation and production of active dry preparations. A comparison of the functional properties of postbiotics and probiotics will be performed by in vitro studies of their antimicrobial, antioxidant and proteolytic activity, as well as ex vivo studies of immunomodulatory activities, adhesion properties and competitive exclusion of potential pathogens on human cell lines. Additionally, in vivo effects of postbiotics and probiotics on the intestinal microbiota, immunity and metabolism of mice with induced diabetes will also be examined. Therefore, research regarding functional effects of live and inactivated microbial LAB cells and their potential bioactive metabolites will contribute to the development of new preparations of postbiotics and probiotics, in liquid and powdered encapsulated form, with the advantage of more economical production using by-products from the dairy industry and greater stability of postbiotics compared to probiotics, which must contain a large number of live microbial cells.]]></summary_en></project><project>
<id>16828</id><title_hr><![CDATA[Izlazak citomegalovirusa iz stanice putem Rab15-pozitivnih membranskih odjeljaka]]></title_hr><title_en><![CDATA[Cytomegalovirus exit from the cell via Rab15-positive membrane compartments]]></title_en><user_id>6604</user_id><user_firstLast_name>Pero Lučin</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2024-05</proposal_call><code>IP-2024-05-4995</code><acronim><![CDATA[ASCO-Rab15]]></acronim><duration>09.12.2024 - 08.12.2027</duration><status>U tijeku</status><financ_value>199.855,92 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Medicine]]></institution_en><team_members_id>6883, 6891, 585, 21237, 21236, 861733, 868150, 6963, </team_members_id><team_members_names><![CDATA[Hana  Mahmutefendić Lučin, Gordana Blagojević Zagorac, Tamara Gulić, Marina Marcelic, Silvija Lukanović Jurić, Ivona Viduka, Alen Omerović, Ljerka Karleuša, ]]></team_members_names><keywords_hr><![CDATA[betaherpesvirus, citomegalovirus, izlazak citomegalovirusa iz stanice, sekundarno omatanje citomegalovirusa,  Rab15]]></keywords_hr><keywords_en><![CDATA[betaherpesviruses, cytomegalovirus, cytomegalovirus egress, cytomegaloviurs secondar envelopment, Rab15]]></keywords_en><summary_hr><![CDATA[Beta-herpesvirusi (BHV) inficiraju velik udio ljudske populacije i razjašnjavanje mehanizama infekcije ključno je za daljnji razvoj antivirusne terapije usmjerene na domaćina. Temeljni procesi konačnog sklapanja viriona u citoplazmi inficirane stanice i pakiranje viriona u membranske organele za oslobađanje iz stanice su vrlo slabo razjašnjeni. Stoga je cilj ovoga projekta je razjasniti mehanizme izlaska mišjeg citomegalovirusa (MCMV), važnog člana BHV porodice. U našim prethodnim projektima smo, uporabom rekombinantnog virusa s fluorescentnim kapsidama (S-mCherry-SCP-MCMV) i kolokalizacijskom analizom 50 markera staničnih odjeljaka, utvrdili nakupljanje virusa u Rab15-pozitivnim odjeljcima (RPO). Ti odjeljci se dijelom preklapaju s markerima endosomalnih reciklirajućih odjeljaka, trans-Golgijeve mreže (TGN) i kasnih endosoma (LE). O fiziološkoj ulozi Rab15 zna se relativno malo. Općenito se smatra endosomalnim Rab-om koji se također uključuje u sekretorne procese. Stoga radna hipoteza novog projektnog prijedloga uključuje dvije komponente: (i) RPO u stanicama inficiranim s MCMV-om su organele u koje se pakiraju novostvoreni virioni i koristite se za masovno oslobađanje multikapsidnih MCMV viriona iz stanice, te (ii) RPO nastaju na membranama podrijetlom iz tubularnih reciklirajućih endosoma i sazrijevaju u sekretorne organele slične lizosomima (LRO) izmjenom membranskog materijala s TGN i LE. Na postavljene hipoteze nastojat će se odgovorit kroz pet ključnih ciljeva projekta: (i) utvrditi identitet i način nastanka RPO (ii) istražiti izražaj Rab15 i njegovih efektora u infekciji, (iii) proizvesti stanične linije s ekspresijom fluorescentnog Rab15, (iv) karakterizirati RPO u živim stanicama DHTM-om (single cell analiza), te (v) utvrditi biološki značaj RPO u pakiranju novostvorenih viriona i oslobađanju infektivnih viriona iz stanice uporabom knockdown (KD) i knockout (KO) molekularno-bioloških alata.]]></summary_hr><summary_en><![CDATA[Beta-herpesviruses (BHV) infect a large proportion of the human population, and elucidation of the mechanisms of infection is of critical importance for the further development of host-targeted antiviral therapy. The basic processes of the final assembly of virions in the cytoplasm of an infected cell and the packaging of virions into membrane organelles for release from the cell are poorly characterized. The aim of this project is therefore to elucidate the mechanisms of exit of mouse cytomegalovirus (MCMV), an important member of the BHV family. In our previous projects, using recombinant viruses with fluorescent capsids and colocalization analysis of 50 markers of membranous organelles, we identified viruses in Rab15-positive compartments (RPC). These organelles partially overlap with markers for tubular recycling endosomes (TREs), the trans-Golgi network (TGN) and late endosomes (LE). Relatively little is known about the physiological role of Rab15, and it is generally regarded as an endosomal Rab that is also involved in secretory processes. Therefore, the working hypothesis of the new research proposal includes two components: (i) RPC in cells infected with MCMV are organelles for packaging of newly formed virions and used for the release of multicapsid viruses from the cell, and (ii) RPC are formed on membranes derived from TREs and mature into lysosome-like secretory organelles (LRO) by exchanging membrane material with TGN and LE. The hypotheses will be tested by five main objectives of the project: (i) establishing the identity and origin of RPC, (ii) studying the expression of Rab15 and its effectors in infections, (iii) producing cell lines with fluorescent Rab15 expression, (iv) characterizing RPC in living cells using DHTM (single cell analysis), and (v) determining the biological significance of RPC in packaging newly formed virions and releasing infectious virions from the cell using molecular biology knockdown (KD) and knockout (KO) tools.]]></summary_en></project><project>
<id>16832</id><title_hr><![CDATA[Više strukture i simetrije u baždarnim i teorijama gravitacije]]></title_hr><title_en><![CDATA[Higher Structures and Symmetries in Gauge and Gravity Theories]]></title_en><user_id>5035</user_id><user_firstLast_name>Athanasios Chatzistavrakidis</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2024-05</proposal_call><code>IP-2024-05-7921</code><acronim><![CDATA[HigSSinGG]]></acronim><duration>10.12.2024 - 09.12.2027</duration><status>U tijeku</status><financ_value>142.878,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>23690, 867871, 1356, 52, 872723, 872759, </team_members_id><team_members_names><![CDATA[Richard Szabo, Peter Schupp, Zoran Škoda, Larisa Jonke, Axel Hrelja, Loukas Grimanellis, ]]></team_members_names><keywords_hr><![CDATA[Kvantna teorija polja, Matematička fizika, Baždarne teorije, Sigma modeli, Algebroidi]]></keywords_hr><keywords_en><![CDATA[Quantum field theory, Mathematical physics, Gauge theories, Sigma models, Algebroids]]></keywords_en><summary_hr><![CDATA[Kvantna teorija polja služi kao univerzalni jezik za razumijevanje fenomena u područjima čestične fizike, fizike kondenzirane materije i gravitacije. Posljednjih godina svjedočimo paradigmskom pomaku u našem razumijevanju globalnih simetrija unutar kvantne teorije polja i njihovih različitih generalizacija. Istovremeno, to je popraćeno plodnom interakcijom između viših struktura u algebri i geometriji s teorijom polja i modelima gravitacije. Ovaj projekt ima za cilj izgradnju čvrstog mosta između tih područja, s fokusom na tri međusobno povezana istraživačka pravca. Prvo, istražit ćemo tenzorske baždarne teorije, obuhvaćajući spinove 1, 2 i više, unutar okvira generaliziranih globalnih simetrija. Takve teorije su relevantne u širem kontekstu viših baždarnih teorija v i za  strukturu gravitacije u infracrvenom području, ali također pružaju učinkovite opise kvazičestica s ograničenom pokretljivošću, poput fraktona. Drugo, proširit ćemo poznatu AKSZ konstrukciju topoloških teorija polja kako bismo analizirali netopološke modele. To uključuje teorije gravitacije s i bez torzije, lisnate  teorije polja i modele  Yang-Millsovog tipa, gdje ćemo razviti nove tehnike lokalizacije za precizno računanje kvantnih opservabli. Na kraju, koristeći moderne metode iz geometrije diferencijalnih gradiranih mnogostrukosti, konstruirat ćemo teoriju gravitacije sličnu Einsteinoj na QP2 mnogostrukostima, istražujući njezine fizičke implikacije u usporedbi s analognnim istraživanjima u supergravitaciji i dvostrukoj teoriji polja. Konsolidacijom odnosa između viših struktura i teorije polja, ovaj istraživački poduhvat značajno će pridonijeti  naporu zajednice u detaljnomm opisu prostora kvantnih teorija polja, određujući one sposobne za pružanje učinkovitih opisa za sustave potencijalno realizirane u prirodi.]]></summary_hr><summary_en><![CDATA[Quantum field theory serves as the universal language for understanding phenomena across particle physics, condensed matter physics, and gravity. Recent years have witnessed a paradigm shift in our understanding of global symmetries within quantum field theory and their various generalizations. At the same time, this is accompanied by a fruitful interaction between higher structures in algebra and geometry with field theory and models of gravity. This project aims to construct a robust bridge between these domains, with a focus on three interconnected research avenues. Firstly, we will explore tensor gauge theories, encompassing spins 1, 2, and higher, within the framework of generalized global symmetries. Such theories are relevant in the broad context of higher gauge theory and for the infrared structure of gravity, but they also provide effective descriptions of quasiparticles with restricted mobility, such as fractons. Secondly, we will extend the celebrated AKSZ construction of topological field theories to analyze non-topological models. These include gravity theories with and without torsion, foliated field theories, and Yang-Mills-like models, where we will develop novel localization techniques for precise computation of quantum observables. Lastly, using modern methods from the geometry of differential graded manifolds, we will construct an Einstein-like gravity theory on QP2 manifolds, exploring its physical implications in comparison to analogous studies in supergravity and double field theory. By consolidating the relationship between higher structures and field theory, this research endeavor will contribute significantly to the ongoing community effort to chart the space of quantum field theories, delineating those capable of furnishing effective descriptions for systems potentially realizable in Nature.]]></summary_en></project><project>
<id>16846</id><title_hr><![CDATA[Primjena dvoelektronske multicentrične veze i jake interakcije pi-šupljine u kristalnom inženjerstvu i dizajnu materijala]]></title_hr><title_en><![CDATA[Application of two-electron multicentre bonding and pi-hole interactions in crystal engineering and materials design]]></title_en><user_id>13343</user_id><user_firstLast_name>Krešimir Molčanov</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2024-05</proposal_call><code>IP-2024-05-8711</code><acronim><![CDATA[CRYSTENG_PANCAKES]]></acronim><duration>16.12.2024 - 15.12.2027</duration><status>U tijeku</status><financ_value>199.755,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, Fizika, </scie_field_hr><scie_field_en>Chemistry, Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>864856, 868153, 21309, 25778, 21308, </team_members_id><team_members_names><![CDATA[Petra Stanić, Anna Krawczuk, Valentina Milašinović, Jelsch Christian, Lidija Kanižaj, ]]></team_members_names><keywords_hr><![CDATA[kristalno inženjerstvo, gustoća naboja, multicentrična veza, radikali, magnetizam, vodljivost, visoki tlak, kvantna kristalografija]]></keywords_hr><keywords_en><![CDATA[crystal engineering, charge density, multicentre bonding, radicals, magnetism, conductivity, high pressure, quantum crystallography]]></keywords_en><summary_hr><![CDATA[Glavni cilj projekta je dizajn i priprava kristala na bazi organskih radikala, spojeva s djelomičnim prijenosom naboja i metal-organskih sustava s radikalima, kod kojih se mogu ugađati prijenos naboja i energijski procjep, te njihov razvoj kao funkcionalnih materijala. Posebna pažnja bit će posvećena prirodi dvoelektronske multicentrične kovalentne veze (2e/mc ili palačinka-veze) između organskih radikala te jakim interakcijama pi-šupljine kod kojih dolazi do prijenosa naboja. Bit će istraživane tri klase spojeva: 1) nove radikalske soli i spojevi s djelomičnim prijenosom naboja, s multicentričnim vezama, 2) metal-organski sustavi s radikalima i 3) spojevi s jakim interakcijama pi-šupljine. U prvoj će se fazi spojevi pripravljati i karakterizirati (kristalna struktura, magnetska, električna i optička svojstva). U drugoj će se fazi detaljno proušavati 2e/mc veze i jake interakcije pi-šupljine u odabranim spojevima kombinacijom određivanja gustoće naboja iz rendgenske difrakcije i periodičnih kvantno-kemijskih računa. Njihovo ponašanje pri ekstremnim uvjetima proučavat će se kristalografijom pri visokom tlaku i temperaturno ovisnom kristalografijom.]]></summary_hr><summary_en><![CDATA[The main goal of the project is to design and prepare crystals of organic radicals, charge-transfer compounds and metal-organic systems with incorporated radicals, suitable for tuning of the charge transfer and band gap, which can be used to design functional materials. Special attention will be given to the nature of two-electron multicentre covalent bonds (2e/mc or pancake bonds) between the organic radicals and strong pi-hole interactions which involve charge transfer. Our work will involve three classes of compounds: 1) novel radical salts and charge transfer compounds with multicentre bonds, 2) metal-organic systems incorporating radicals and 3) compounds with strong pi-hole interactions. The first phase will be preparation and characterisation of the novel compounds (crystal structure, magnetic, electrical and optical properties). In the second phase we will undertake a thorough experimental study of the 2e/mc bonds and strong pi-hole interactions in selected compounds by X-ray charge density coupled by periodic quantum chemical computations. Study under non-ambient conditions will involve high-pressure and variable-temperature single-crystal X-ray diffraction. ]]></summary_en></project><project>
<id>16847</id><title_hr><![CDATA[SOLNI DIJAPIRI I AKTIVNA TEKTONIKA SREDNJEG JADRANA]]></title_hr><title_en><![CDATA[SALT DIAPIRS AND ACTIVE TECTONICS IN THE CENTRAL ADRIATIC]]></title_en><user_id>13721</user_id><user_firstLast_name>Tvrtko Korbar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2024-05</proposal_call><code>IP-2024-05-2957</code><acronim><![CDATA[SALTECTA]]></acronim><duration>16.12.2024 - 15.12.2027</duration><status>U tijeku</status><financ_value>188.990,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Geologija, Geofizika, </scie_field_hr><scie_field_en>Geology, Geophysics, </scie_field_en><institution_hr><![CDATA[Hrvatski geološki institut]]></institution_hr><institution_en><![CDATA[Croatian Geological Survey]]></institution_en><team_members_id>26640, 22540, 868146, 3963, 17774, 13024, 24305, 40, 872882, </team_members_id><team_members_names><![CDATA[Ana Kamenski, David Rukavina, Tiago Alves, Lara Wacha, Dea Brunović, Damir Palenik, Marko Budić, Snježana Markušić, Chahreddine Neji, ]]></team_members_names><keywords_hr><![CDATA[Srednji Jadran, Solna tektonika, Dijapiri, Aktivni rasjedi, Potresi]]></keywords_hr><keywords_en><![CDATA[Central Adriatic, Salt tectonics, Diapirs, Active faults, Earthquakes]]></keywords_en><summary_hr><![CDATA[Srednji Jadran je predgorje dvaju orogenih sustava – Dinarida na sjeveroistoku i Apenina na jugozapadu. Osim specifične predgorske tektonike, to područje obilježavaju i brojni solni dijapiri koji su uglavnom različito prikazivani na objavljenim preglednim kartama i ilustracijama geoloških profila, a tek sporadično na interpretiranim seizmičkim profilima. Solni dijapiri čine impozantne potpovršinske strukture koje mjestimice izbijaju na površinu i tako utječu na morfologiju (batimetriju) tog područja. Solne strukture srednjeg Jadrana su znanstveno nedovoljno istražene, a nije istraživana niti uzročno-posljedična veza solnih dijapira i umjerene seizmičke aktivnosti koja obilježava to područje. Pretpostavlja se da je aktivnost dijapira vezana uz neotektonsku reaktivaciju mezozojskih rasjeda, od kojih su neki vjerojatno i danas aktivni. Projektom se namjeravaju interpretirati najnoviji 2D seizmički profili snimljeni na tom području, reinterpretirati gravimetrijski podatci, definirati glavni rasjedi te 3D modelirati geometrija odabranih solnih struktura. Strukturno-tektonski sklop (re)definirati će se na pučinskim otocima srednjeg Jadrana. Uspoređivanjem prostornog rasporeda epicentara i hipocentara zabilježenih potresa s interpretiranim geološkim strukturama, pokušat će se razjasniti povezanost aktivne tektonike sa solnim dijapirima. Istraživanjem i datiranjem solnih stijena iz dijapira pokušat će se definirati taložni okoliši i starost tih ključnih naslaga, a datiranjem pokrovnih kenozojskih naslaga će se pokušati odrediti vrijeme pojave solnih dijapira i s njima udruženih stijena na površini. ]]></summary_hr><summary_en><![CDATA[The central Adriatic is the foreland of two orogenic systems - the Dinarides on the northeast and the Apennines on the southwest. In addition to specific foreland tectonics, this area is also marked by numerous salt diapirs, which have mostly been shown differently on published overview maps and illustrated geological cross-sections, and only sporadically on interpreted seismic cross-sections. Salt diapirs form imposing subsurface structures that in places emerge on the surface and thus affect the morphology (bathymetry) of that area. Salt structures of the central Adriatic are scientifically underexplored, as well as the cause-and-effect relationship between the salt diapirs and moderate seismic activity that characterizes this area. It is assumed that the activity of the diapirs are related to the neotectonic reactivation of Mesozoic faults, some of which are probably still active. The project intends to interpret the latest 2D seismic cross-sections recorded in the area, to define the main faults, and to 3D model the geometry of selected diapiric structures. The structural-tectonic setting will be (re)defined on the offshore islands of the central Adriatic. By comparing the spatial arrangement of epicenters and hypocenters of recorded earthquakes with interpreted geological structures, an attempt will be made to clarify the connection between active tectonics and salt diapirs. Focused research on the salt rocks from the diapirs will be made with a goal to define the depositional environment and the age of these key-deposits, while dating of the overlaying Cenozoic deposits could reveal the timing of the appearance of salt diapirs and the associated rocks on the surface.]]></summary_en></project><project>
<id>16848</id><title_hr><![CDATA[Medicinska edukacija i planiranje uz pomoć produžene stvarnosti]]></title_hr><title_en><![CDATA[MEDIcal TRAINing and planning through Extended Reality]]></title_en><user_id>21436</user_id><user_firstLast_name>Irena Galić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2024-05</proposal_call><code>IP-2024-05-9492</code><acronim><![CDATA[MEDITRAIN]]></acronim><duration>16.12.2024 - 15.12.2027</duration><status>U tijeku</status><financ_value>197.800,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, Interdisciplinarne tehničke znanosti, </scie_field_hr><scie_field_en>Computer sciences, Interdisciplinary technological sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera Osijek, Fakultet elektrotehnike, računarstva i informacijskih tehnologija Osijek]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Electrical Engineering, Computer Science and Information Technology Osijek]]></institution_en><team_members_id>24844, 856226, 865511, 866507, 866525, 868165, 22473, 27236, 868154, 868348, 22468, 872884, </team_members_id><team_members_names><![CDATA[Marija Habijan, Marin Benčević, Dario Mužević, Aleksandra Pizurica, Danilo Babin, Ivana Hartmann Tolić, Krešimir Romić, Robert Šojo, Maja Košuta Petrović, Vjekoslav Kopačin, Hrvoje Leventić, Juraj Perić, ]]></team_members_names><keywords_hr><![CDATA[Obrada medicinskih slika, strojno učenje, detekcija urasle posteljice, cerebrovaskularne procedure, produžena stvarnost  ]]></keywords_hr><keywords_en><![CDATA[Medical Image Processing, Machine Learning, Placenta Accreta Detection, Cerebrovascular procedures, Extended Reality (XR), ]]></keywords_en><summary_hr><![CDATA[Upotreba proširene stvarnosti (XR) u medicinskoj edukaciji i planiranju operativnih zahvata donosi značajne promjene u medicinskoj praksi. Napredni XR sustavi omogućuju stvaranje interaktivnih i realističnih simulacija, olakšavajući pripremu za složene operacije i pružajući dodatne informacije tijekom samih zahvata. Unatoč brzom razvoju ove tehnologije, postoji potreba za rješavanjem izazova vezanih uz dostupnost podataka, generiranje sintetičkih slučajeva i standardizaciju edukacije. Ovaj projekt je usmjeren na razvoj novih metoda i sustava koji će unaprijediti medicinsku edukaciju i planiranje operacija za specifična medicinska stanja i procedure. Cilj je razviti inovativne metode za simulaciju i analizu medicinskih slika uz pomoć algoritama strojnog učenja kojima će se (1) povećati iskustvo liječnika o urasloj posteljici i važnosti  njezina pregleda u trudnoći s ciljem smanjenja stope propuštenih slučajeva detekcije urasle posteljice pri pregledu trudnica ultrazvukom te (2) povećati lakoću izvedbe i kvalitetu cerebrovaskularnih zahvata izradom detaljne i realistične VR/XR simulacije specifičnih neurokirurških zahvata. Planirani sustavi se ističu po svojim inovativnim metodama u sintezi medicinskih slika. Za potrebe simulacije pregleda ultrazvuka razvit će se metode za sintezu realističnih ultrazvučnih slika iz slika magnetske rezonance koristeći spoj tradicionalnih i suvremenih metoda. Prilikom simulacije cerebrovaskularnih kirurških zahvata planira se razviti metoda koja će na temelju metoda generativne umjetne inteligencije kreirati nove, realistične i zahtjevne slučajeve ovisno o zadanim medicinskim parametrima. Rezultat projekta je  niz programskih biblioteka otvorenog koda koje će sadržavati sve razvijene metode tijekom projekta. Razvijene metode sintetičkog generiranja medicinskih slika omogućit će stvaranje raznovrsnih edukacijskih slučajeva, dok će VR/XR simulacije pružiti medicinskim stručnjacima priliku da unaprijede svoje vještine u sigurnom okruženju.]]></summary_hr><summary_en><![CDATA[The use of extended reality (XR) in medical education and surgical procedure planning brings significant changes to medical practice. Advanced XR systems enable the creation of interactive and realistic simulations, facilitating preparation for complex surgeries and providing additional information during the procedures themselves. Despite rapid technological development, challenges remain related to data availability, generation of synthetic cases, and standardization of education. This project focuses on developing new methods and systems to enhance medical education and surgical planning for specific conditions and procedures. The goal is to develop innovative methods for education, simulation, and analysis of medical images using machine learning algorithms that will (1) increase doctors&#39; experience regarding placenta accreta and the importance of its examination during pregnancy, thereby reducing the rate of missed cases of placenta accreta detection during ultrasound examination, and (2) increase the ease of execution and quality of cerebrovascular procedures by creating detailed and realistic VR/XR simulations of specific neurosurgical procedures. The planned systems stand out for their innovative methods in medical image synthesis. For ultrasound examination simulation, methods will be developed to synthesize realistic ultrasound images from magnetic resonance images using a combination of traditional and modern techniques. During the simulation of cerebrovascular surgical procedures, a generative artificial intelligence method will create new, realistic, and challenging cases based on given medical parameters. The project will result in a series of open-source software libraries containing all the methods developed. The methods for synthetic generation of medical images will enable the creation of diverse educational cases, while VR/XR simulations will provide medical professionals the opportunity to improve their skills in a safe environment.]]></summary_en></project><project>
<id>16850</id><title_hr><![CDATA[Računalni uvid u razvoj neurodegeneracije uslijed COVID-19 infekcije]]></title_hr><title_en><![CDATA[Computational Insight into the Development of Neurodegeneration following COVID-19 Infection]]></title_en><user_id>227</user_id><user_firstLast_name>Robert Vianello</user_firstLast_name><svouser_id>17513</svouser_id><svouser_firstLast_name>Janez Mavri</svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2024-05</proposal_call><code>IP-2024-05-3953</code><acronim><![CDATA[NeuroDegCompIns]]></acronim><duration>20.12.2024 - 19.12.2027</duration><status>U tijeku</status><financ_value>184.759,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>24248, 867578, 17513, </team_members_id><team_members_names><![CDATA[Tana Tandarić, Lucija Vrban, Janez Mavri, ]]></team_members_names><keywords_hr><![CDATA[neurodegeneracija, monoaminooksidaza, SARS-CoV-2 virus, COVID-19 infekcija, računalne simulacije]]></keywords_hr><keywords_en><![CDATA[neurodegeneration, monoamine oxidase, SARS-CoV-2 virus, COVID-19 infection, computational simulations]]></keywords_en><summary_hr><![CDATA[Predloženi projekt okuplja stručan tim istraživača s bogatim iskustvom u računalnim tehnikama povezanim s monoaminergičkim sustavima mozga. Cilj je pružiti molekularne i mehanističke uvide u neurodegeneraciju izazvanu COVID-19 infekcijom, uznemirujući medicinski problem koji se trenutno široko raspravlja u literaturi. Projekt je zajednički napor grupa pod vodstvom dr. Roberta Vianella (Hrvatska) i dr. Janeza Mavrija (Slovenija), oslanjajući se na njihovu dokazanu sposobnost suradnje i kvalitetu dosadašnjih rezultata. Projekt je fokusiran na dva izoenzima monoaminske oksidaze, MAO A i MAO B, koji reguliraju razine neurotransmitera u mozgu te predstavljaju središnju metu farmakoloških intervencija za neurodegeneraciju u posljednjih 60 godina. Naš pristup oslanja se na korištenje niza računalnih metoda za ispitivanje utjecaja proteina šiljka različitih varijanti SARS-CoV-2 virusa na aktivnost MAO enzima, temeljem kliničkih rezultata po kojima oko 36% pojedinaca zaraženih COVID-19 virusom pokazuje neurološke simptome. To uključuje predviđanje afiniteta vezanja proteina šiljka za MAO i usporedbu s onima za ACE2 receptore, koje virus koristi za ulazak u stanice domaćina, a kako bi se procijenila izglednost formiranja kompleksa između proteina šiljka i MAO enzima. Ovi kompleksi bit će ispitani za njihov utjecaj na (i) katalitičku aktivnost MAO prema različitim neurotransmiterima, (ii) efikasnost kliničkih inhibitora za inaktivaciju MAO, (iii) sposobnost L-DOPA povećanju razina dopamina, te (iv) obnovu MAO funkcionalnosti molekularnim kisikom, koji reaktivira FAD koenzim i proizvodi H2O2, signalnu molekulu koja doprinosi neurodegeneraciji. Uspoređujući rezultate za izvorne enzime s onima koji uključuju komplekse s proteinima šiljka, nadamo se istaknuti bilo kakvu potencijalnu povezanost između bolesti mozga i SARS-CoV-2 infekcija, što će izgledno potaknuti daljnja klinička istraživanja, olakšavajući time rano dijagnosticiranje i pravovremene terapijske intervencije. ]]></summary_hr><summary_en><![CDATA[This project brings together a skilled team of researchers with broad expertise in computational techniques related to the brain monoaminergic systems. The goal is to provide molecular and mechanistic insights into the COVID-19 induced neurodegeneration, a disturbing medical issue currently widely discussed in the literature. The project is a collaborative effort between groups led by Dr. Robert Vianello (Croatia) and Dr. Janez Mavri (Slovenia), relying on their proven ability to work together and the quality of their past achievements. The project is centered on two critical monoamine oxidase isozymes, MAO A and MAO B, which regulate brain neurotransmitter levels and have been the central target in pharmacological interventions for neurodegeneration in the last 60 years. Our approach includes employing a range of computational methods to examine how the spike protein from different SARS-CoV-2 variants influences MAO activity, based on observations that around 36% of COVID 19 infected individuals display neurological symptoms. This involves predicting the binding affinities of spike proteins to MAOs and comparing them with those for ACE2 receptors, used by the virus to enter host cells, in order to assess the feasibility of the spike protein–MAO complex formation. The latter will be evaluated for their impact on (i) the MAO catalytic activity for neurotransmitter substrates, (ii) the potency of clinical inhibitors to inactivate MAO, (iii) the ability of L-DOPA to increase dopamine levels, and (iv) the restoration of MAO functionality by molecular oxygen, which reactivates the FAD co-factor and produces H2O2, a contributor to neurodegeneration. By comparing the results for native enzymes to those involving spike protein–MAO complexes, we hope to highlight any potential associations between brain disorders and SARS-CoV-2 infections, which, in turn, may encourage further clinical research, facilitating early diagnosis and timely therapeutic interventions. ]]></summary_en></project><project>
<id>16863</id><title_hr><![CDATA[Ex vivo/in vitro model za procjenu učinkovitosti onkolitičke viroterapije]]></title_hr><title_en><![CDATA[Ex vivo/in vitro Model for Oncolytic Virotherapy Efficacy evaluation]]></title_en><user_id>102</user_id><user_firstLast_name>Beata Halassy</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2024-05</proposal_call><code>IP-2024-05-4740</code><acronim><![CDATA[MOVE]]></acronim><duration>18.12.2024 - 17.12.2027</duration><status>U tijeku</status><financ_value>199.985,00 eur</financ_value><scie_area_hr>Interdisciplinarno područje znanosti</scie_area_hr><scie_area_en>Interdisciplinary scientific area</scie_area_en><scie_field_hr>Biotehnologija u biomedicini, </scie_field_hr><scie_field_en>Biotechnology in Biomedicine, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu]]></institution_hr><institution_en><![CDATA[University of Zagreb]]></institution_en><team_members_id>865053, 1144, 12959, 25068, 19398, 4852, 824, 551, 23928, 936, 12414, 874034, </team_members_id><team_members_names><![CDATA[Erika Gamulin, Tihana Kurtović, Maja Lang Balija, Sanja Mateljak Lukačević, Ivan Butkovic, Adela Štimac, Lidija Medven Zagradišnik, Sanda Ravlić, Snježana Ramić, Dubravko Forčić, Melita Perić Balja, Lucija Ivandić, ]]></team_members_names><keywords_hr><![CDATA[onkolitička viroterapija, virus ospica, virus zaušnjaka, virus vezikularnog stomatitisa, rak dojke, ex vivo/in vitro model]]></keywords_hr><keywords_en><![CDATA[oncolytic virotherapy, measles virus, mumps virus, vesicular stomatitis virus, breast cancer, ex vivo/in vitro model]]></keywords_en><summary_hr><![CDATA[Imunoterapija onkolitičkim virusima (OVT) je terapijski pristup liječenju raka u kojem se koriste virusi sa sposobnošću replikacije selektivnost u tumorskim tkivima. Oni ubijaju tumorske stanice in situ, oslobađaju tumorske antigene i potiču razvoj imuniteta specifičnog za tumor, iako identitet tumorskih antigena nije poznat, djelujući tako poput antigen-agnostičkih cjepiva. Unatoč velikom broju pretkliničkih znanstvenih dokaza koji pokazuju učinkovitost onkolitičkih virusa (OV) u suzbijanju tumora, OVT još nije dosegnula svoj puni potencijal u kliničkoj upotrebi, budući da rezultati kliničkih ispitivanja često ne odražavaju očekivanja temeljena na pretkliničkim podacima. Trenutni pretklinički in vitro modeli (tumorske stanične linie) i in vivo modeli (miševi s mišjim tumorima i miševi s presađenim ljudskim tumorima) su se pokazali neprikladnima za predviđanje učinkovitosti i sigurnosti kod ljudi. S ekspertizom u virologiji i imunologiji virusa ospica, zaušnjaka i vezikularnog stomatitisa, koji svi pripadaju obećavajućim platformama onkolitičkih virusa u razvoju, tražit ćemo pouzdanu metodologiju koja bi mogla odgovoriti je li tumor pojedinog pacijenta osjetljiv na ove viruse. Predložena metodologija temelji se na kratkotrajnom in vitro uzgoju tkiva raka dojke u 2D i 3D formatu, kontroliranom infekcijom s OV-ima i traženju pokazatelja replikacije virusa unutar tumorskog tkiva. Uspjeh u uspostavljanju takvog ex vivo/in vitro modela može približiti ovu novu imunoterapiju primjeni i pružiti osnovu za personalizaciju budućeg onkolitičkog liječenja malignih bolesti.]]></summary_hr><summary_en><![CDATA[Oncolytic virus immunotherapy (OVT) is a therapeutic approach to cancer treatment in which viruses with selective replication ability in tumor tissues are utilized. They kill tumor cells in situ, release tumor antigens, and promote the development of tumor-specific immunity, even though the identity of tumor antigens is unknown, thus acting as antigen-agnostic vaccines. Despite a large body of preclinical scientific evidence demonstrating the efficacy of oncolytic viruses (OV) in tumor suppression, OVT has not yet fully realized its potential in clinical use, as clinical trial results often do not align with expectations based on preclinical data. Current preclinical in vitro models (tumor cell lines) and in vivo models (mice with murine tumors and mice with transplanted human tumors) have proven inadequate for predicting efficacy and safety in humans. With expertise in virology and immunology of measles virus, mumps virus, and vesicular stomatitis virus, all of which belong to promising oncolytic virus platforms under development, we will seek a reliable methodology to determine whether an individual patient&#39;s tumor is susceptible to these viruses. The proposed methodology is based on short-term in vitro cultivation of breast cancer tissue in 2D and 3D formats, controlled infection with OV, and identification of markers of virus replication within the tumor tissue. Success in establishing such an ex vivo/in vitro model could bring this new immunotherapy closer to application and provide a foundation for personalizing future oncolytic treatments for malignant diseases.]]></summary_en></project><project>
<id>16865</id><title_hr><![CDATA[Oksidacija lipida u staničnim membranama vlakanastih stanica leće oka kao mogući čimbenik u razvoju mrene]]></title_hr><title_en><![CDATA[Lipid oxidation in the plasma membranes of the eye lens fiber cells as a possible factor in the development of age-related cataracts]]></title_en><user_id>6123</user_id><user_firstLast_name>Marija Raguž</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2024-05</proposal_call><code>IP-2024-05-3923</code><acronim><![CDATA[LipidOx]]></acronim><duration>20.12.2024 - 19.12.2027</duration><status>U tijeku</status><financ_value>200.000,00 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Split School of Medicine]]></institution_en><team_members_id>24061, 868121, 867957, 97, 2558, 20309, 856215, 868079, 868174, 868193, 872942, </team_members_id><team_members_names><![CDATA[Witold Subczynski, Wieslaw Gruszecki, Rafal Luchowski, Ante Bilusic, Marina Tranfić Bakić, Ljubo Znaor, Ivan Mardešić, Justyna Widomska, Filip Rađa, Ante Krešo, Mateo Šerić, ]]></team_members_names><keywords_hr><![CDATA[Oksidacija lipida, stanična membrana, vlaknaste stanice leće oka, mrena, kolestrol, kolesterolova domena]]></keywords_hr><keywords_en><![CDATA[Lipid oxidation, plasma membranes, eye lens fiber cells, cataracts, cholesterol, cholesterol bilayer domain]]></keywords_en><summary_hr><![CDATA[Jedan od najčešćih uzroka gubitka vida u svijetu je očna mrena. Kirurški zahvat je trenutno jedino učinkovito liječenje. Povećanje koncentracije kisika unutar leće i stvaranje reaktivnih spojeva kisika uzroci su nastanka mrene. Razlozi razvoja mrene nisu poznati, ali dokazi upućuju na to da prisutnost visoke razine kolesterola (KO) i domena kolesterolovih dvosloja (DKD) u očnoj leći pomaže pri održavanju prozirnosti i sprječavanju nastanka mrene. DKD također osigurava zasićenost okolnog fosfolipidnog dvosloja kolesterolom. Visoki sadržaj KO u membranama vlaknastih stanica osigurava da fizička svojstva lipidnih membrana ostanu nepromijenjena i neovisna o promjenama u sastavu fosfolipida. Dakle, DKD pomaže u održavanju homeostaze membrane leće, dok se fosfolipidni sastav membrane značajno mijenja s godinama. Naš je cilj razumjeti kako se plazma membrana vlaknastih stanica leće, a posebice lipidni dio dvosloja, mijenja tijekom starenja i stvaranja mrene kako bi se mogle razviti i procijeniti alternativne strategije za prevenciju, usporavanje progresije i izlječenje. Dugoročni cilj je razumjeti ulogu membrane očne leće u održavanju prozirnosti. Membrane leća imaju jedinstven lipidni sastav i strukturu za koje se smatra da održavaju nisku koncentraciju kisika u unutrašnjosti leće. U ovom projektu ćemo (1) prilagoditi i poboljšati metode za pripremu lipidnih modelnih membrana s visokim sadržajem Chol u fiziološkim uvjetima, (2) testirati hipotezu da lipidna peroksidacija može drastično promijeniti organizaciju lipida u modelnim membranama inducirajući stvaranje DKD i KO kristala pri niskom udjelu KO i (3) potvrditi utjecaj peroksidacije lipida na promjene u lateralnoj organizaciji lipida leće i netaknutih staničnih membrana vlaknastih stanica leće oka. Naša istraživanja temeljit će se na korištenju spektroskopskih i mikroskopskih metoda.]]></summary_hr><summary_en><![CDATA[One of the most common causes of vision loss in the world is cataracts. Surgery is currently the only effective treatment. An increase in the oxygen concentration within the lens and the formation of reactive oxygen species are the causes of cataract formation. The reason for the development of cataracts is not known, but evidence suggests that the presence of high levels of cholesterol and cholesterol bilayer domains (CBD) in the eye lens helps to maintain transparency and prevent the formation of cataracts. CBD also ensures that the surrounding phospholipid bilayer is saturated with cholesterol. The saturating cholesterol content in the fiber cell membranes ensures that the physical properties of the lens lipid membranes remain consistent and independent of changes in phospholipid composition. Thus, CBD helps to maintain the homeostasis of lens membranes, while the membrane phospholipid composition changes significantly with age. Our goal is to understand how the fiber cell plasma membrane in the lens, particularly their lipid bilayer portion, change during aging and cataract formation so that alternative strategies for prevention, slowing progression and cure can be developed. The long-term goal is to understand the role of the eye lens membranes in maintaining lens transparency. Lens membranes have unique lipid composition and structure thought to maintain low oxygen concentration inside the lens interior. In this project, we will (1) adapt and improve methods for preparation of lipid model membranes with high Chol content under physiological conditions, (2) test the hypothesis that lipid peroxidation can drastically change organization of lipids in model membranes by inducing the formation of CBDs and Chol crystals at low Chol content, and (3) verify the influence of lipid peroxidation on changes in the lateral organization of lens lipid and intact fiber cell plasma membranes. Our studies will be based on the use of spectroscopic and microscopic methods.]]></summary_en></project><project>
<id>16869</id><title_hr><![CDATA[Otkrivanje poveznica između peripartalnog mentalnog i metaboličkog zdravlja putem metabolomičkih i genetičkih analiza]]></title_hr><title_en><![CDATA[Uncovering Links between Peripartum Mental and Metabolic Health through Metabolomic and Genetic Analyses]]></title_en><user_id>519</user_id><user_firstLast_name>Jasminka Štefulj</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2024-05</proposal_call><code>IP-2024-05-4961</code><acronim><![CDATA[LinkMe]]></acronim><duration>16.12.2024 - 15.12.2027</duration><status>U tijeku</status><financ_value>199.470,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>28681, 23790, 5996, 868265, 5314, 22574, 861748, 19126, 12342, 5668, 873065, 23665, 871157, </team_members_id><team_members_names><![CDATA[Maja Perić, Ivona Bečeheli, Maja Kesić, Martin Hill, Dubravka Hranilovic, Barbara Nikolić, Maja Žutić, Sandra Nakić Radoš, Marina Ivanisevic, Lipa Čičin-Šain, Marta Kaloper, Marcela Konjevod, Barbara Marić, ]]></team_members_names><keywords_hr><![CDATA[trudnoća, gestacijski dijabetes, peripartalno mentalno zdravlje, metabolomika, polimorfizmi, serotonin, posteljica, masno tkivo]]></keywords_hr><keywords_en><![CDATA[pregnancy, gestational diabetes mellitus, peripartum mental health, metabolomics, polymorphisms, serotonin, placenta, adipose tissue]]></keywords_en><summary_hr><![CDATA[Sve je više dokaza o povezanosti metaboličkog i mentalnog zdravlja tijekom peripartalnog razdoblja. Gestacijski dijabetes melitus (GDM), najčešći metabolički poremećaj u trudnica, rizični je čimbenik za razvoj simptoma peripartalne depresije i anksioznosti, i obrnuto, pojačani simptomi ovih psihičkih problema čimbenik su rizika za GDM. Oba su stanja neovisno, a još više u kombinaciji, povezana s povećanim rizikom od nepovoljnih ishoda i za majku i za dijete. Međutim, biološki mehanizmi u podlozi odnosa peripartalnog mentalnog i metaboličkog zdravlja slabo su poznati. Stoga LinkMe projekt ima za cilj doprinijeti boljem razumijevanju preklapajućih i diskriminirajućih bioloških korelata peripartalnog mentalnog i metaboličkog zdravlja provedbom neciljanih metabolomičkih analiza, analizom polimorfizma gena kandidata i procjenom serotoninski parametara u krvi. Putem neciljanih metabolomičkih analiza uzoraka plazme trudnica, cilj nam je identificirati metabolite i metaboličke putove povezane s GDM-om kao i sa simptomima peripartalne depresije i anksioznosti u žena s normalnom tolerancijom glukoze i GDM-om. Putem komplementarnih neciljanih metabolomičkih analiza uzoraka plazme pupkovine, cilj nam je identificirati metaboličke putove koji su pod utjecajem metaboličkog i mentalnog zdravlja majke, unapređujući tako razumijevanje razvojnog porijekla zdravlja i bolesti. Paralelno, analizirat ćemo ekspresiju odabranih gena u relevantnim metaboličkim tkivima koja reguliraju fiziologiju majke tijekom trudnoće, posteljici i masnom tkivu. Analize genskih polimorfizama usredotočit će se na gene serotoninskog puta i kandidate iz dostupne literature. Predložene studije poboljšat će naše razumijevanje bioloških osnova peripartalnog metaboličkog i mentalnog zdravlja i mogu imati implikacije za kliničku praksu u budućnosti.]]></summary_hr><summary_en><![CDATA[There is increasing evidence of a link between metabolic and mental health during the peripartum period. Gestational diabetes mellitus (GDM), the most common metabolic disorder in pregnant women, is a risk factor for the development of peripartum depression and anxiety symptoms, and conversely, increased symptoms of these mental health problems are a risk factor for GDM. Both conditions are independently and even more so in combination associated with an increased risk of adverse outcomes for both mother and child. However, the biological mechanisms underlying the relationship between peripartum mental and metabolic health are poorly understood. Therefore, the LinkMe project aims to contribute to a better understanding of the overlapping and discriminative biological correlates of peripartum mental and metabolic health by performing untargeted metabolomic analyses, assessing candidate gene polymorphism and evaluating blood serotonin parameters. Through untargeted metabolomic analyses of plasma samples from pregnant women, we aim to identify metabolites and metabolic pathways associated with both GDM as well as with symptoms of peripartum depression and anxiety in women with normal glucose tolerance and GDM. Through complementary untargeted metabolomic analyses of cord plasma samples, we aim to identify metabolic pathways that are influenced by maternal metabolic and mental health, advancing thus our understanding of the developmental origins of health and disease. In parallel, we will perform expression analyses of selected genes in relevant metabolic tissues that regulate maternal physiology during pregnancy, i. e. in the placenta and adipose tissue. The analyses of genetic polymorphisms will focus on serotonin pathway genes and candidates from the available literature. The proposed studies will improve our understanding of the biological basis of peripartum metabolic and mental health and may have implications for clinical practice in the future.]]></summary_en></project><project>
<id>16873</id><title_hr><![CDATA[Remisija dijabetesa tipa 2 pomoću mediteranske prehrane, tjelesne aktivnosti i psihološke potpore: randomizirana klinička studija]]></title_hr><title_en><![CDATA[Remission of type 2 diabetes with Mediterranean diet, physical activity and psychological support: a randomized clinical trial]]></title_en><user_id>1358</user_id><user_firstLast_name>Ivana Kolčić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2024-05</proposal_call><code>IP-2024-05-3757</code><acronim><![CDATA[REMeDI2ME]]></acronim><duration>18.12.2024 - 17.12.2027</duration><status>U tijeku</status><financ_value>199.523,00 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo, Društvene znanosti, Biotehničke znanosti, Prirodne znanosti, Tehničke znanosti, </scie_area_hr><scie_area_en>Biomedicine and health sciences, Social sciences, Biotechnical sciences, Natural sciences, Technological sciences, </scie_area_en><scie_field_hr>Kliničke medicinske znanosti, Kemija, Računarstvo, Temeljne medicinske znanosti, Javno zdravstvo i zdravstvena zaštita, Nutricionizam, Psihologija, Kineziologija, </scie_field_hr><scie_field_en>Clinical sciences, Chemistry, Computer sciences, Basic Medical Sciences, Public health and health services, Nutrition, Psychology, Kinesiology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Split School of Medicine]]></institution_en><team_members_id>29604, 4585, 868194, 22547, 65, 868172, 868233, 100, 22679, 868300, 64, 27180, 868339, 868341, 868282, 2542, 4553, 20029, 872961, </team_members_id><team_members_names><![CDATA[Mario Marendić, Darko Modun, Hellas Cena, Leo Mršić, Joško Božić, Marko Kumrić, Rachele De Giuseppe, Franko Burčul, Tanja Dragun, Dora Bučan Nenadić, Anela NOVAK, Barbara Gilić, Tanja Ilić Begović, Nikolina Polić, Antonia Peroš, Ivana Mudnić, Zoran Đogaš, Marion Tomičić, Ivana Grgić, ]]></team_members_names><keywords_hr><![CDATA[dijabetes tip 2, remisija, pretilost, mediteranska prehrana, tjelesna aktivnost, stres, zdrav način života, mršavljenje, biomarkeri]]></keywords_hr><keywords_en><![CDATA[type 2 diabetes, remission, obesity, Mediterranean diet, physical activity, stress, healthy lifestyle, weight loss, biomarkers]]></keywords_en><summary_hr><![CDATA[Dijabetes tipa 2 (DM2) i pretilost vodeći su uzroci morbiditeta i mortaliteta, kao i velikog financijskog tereta društva. Glavni cilj ovog eksperimentalnog istraživanja je postizanje remisije DM2, korištenjem intenzivne promjene životnog stila: mediteranske prehrane, tjelesne aktivnosti i psihosocijalne potpore. U ovom multidisciplinarnom projektu, kojeg će provoditi znanstvenici 5 znanstvenih područja, sudjelovat će 120 ispitanika s dijagnozom DM2 postavljenom unutar 6 godina, s indeksom tjelesne mase 27-45 kg/m2, bez terapije inzulinom i težih komplikacija. Nasumičnim odabirom ispitanici će se podijeliti u eksperimentalnu i kontrolnu skupinu. Eksperimentalna skupina će se hraniti prema principima mediteranske prehrane s blagim kalorijskim deficitom, pod nadzorom nutricioniste, provoditi svakodnevnu tjelesnu aktivnost pod nadzorom kineziologa te ojačati otpornost na stres uz potporu psihologa i grupnog rada, sve uz kontrolu liječnika specijalista i depreskripciju lijekova prema potrebi. Intervencija uključuje tjedno individualno i grupno savjetovanje i radionice kroz 6 mjeseci, nakon čega će se ispitanici pratiti još 1,5 g. Kontrolna skupina će se pratiti 2 godine, uz savjetovanje o ulozi zdravih životnih navika i uobičajenu kliničku skrb. Glavni ishodi istraživanja su remisija DM2 (HbA1c<6,5%) i gubitak mase od >15 kg, s dodatnim ishodima poboljšanja niza kliničkih parametara i biomarkera: inzulinske rezistencije, upale niskog stupnja, oksidativnog stresa, glikana, endokrinih disruptora i obesogena, uz praćenje nuspojava (sekundarni ishod), što će osigurati preduvjete za unapređenje personalizirane brige za zdravlje osoba s DM2. Ovaj projekt ima visoki potencijal za ostvarivanje translacije spoznaja, s višestrukim pozitivnim učincima na zdravstvenu skrb, kao i za postizanje iznimnog znanstvenog doprinosa. Kao posljedica svega navedenog, uspješno proveden projekt ove tematike može rezultirati dalekosežnim pozitivnim društvenim i gospodarskim učincima.]]></summary_hr><summary_en><![CDATA[Type 2 diabetes (DM2) and obesity are leading causes of morbidity and mortality, with a large financial burden on society. The main goal of this experimental study is to achieve DM2 remission, using intensive lifestyle intervention: Mediterranean diet, physical activity and psychosocial support. In this multidisciplinary project, carried out by scientists from 5 scientific fields, 120 subjects will be included, diagnosed with DM2 within 6 years, a body mass index of 27-45 kg/m2, without insulin therapy or severe complications. Subjects will be randomly allocated to experimental or control group. Experimental group will eat Mediterranean diet with a mild caloric deficit, under the supervision of a nutritionist, perform daily physical activity under the supervision of a kinesiologist, and strengthen resilience to stress with the support of a psychologist and group work, all under the supervision of physicians, and deprescription of medications as needed. The intervention includes weekly individual and group counseling and workshops for 6 months, with 1.5 years of follow-up. The control group will be followed for 2 years, and advised on the role of healthy lifestyle, while having the usual clinical care. The main outcomes of the study are DM2 remission (HbA1c<6.5%) and weight loss of >15 kg, with additional outcomes of improvement in clinical parameters, and a number of biomarkers: insulin resistance, low-grade inflammation, oxidative stress, glycans, endocrine disruptors and obesogens, while monitoring for side effects (secondary outcome). All of this will provide the prerequisites for the improvement of the personalized medical care for people with DM2. This project has a high potential for knowledge translation, with multiple positive effects on the provision of health care, as well as achieving exceptional scientific contribution. As a consequence, successfully implemented project on this topic can result in far-reaching positive social and economic effects.]]></summary_en></project><project>
<id>16902</id><title_hr><![CDATA[Izotopni otisak stratificiranog morskog jezera (Zmajevo oko)]]></title_hr><title_en><![CDATA[Stable isotope signatures of a stratified marine lake (Zmajevo Oko)]]></title_en><user_id>287</user_id><user_firstLast_name>Irena  Ciglenečki-Jušić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2024-05</proposal_call><code>IP-2024-05-2377</code><acronim><![CDATA[ISO-ZOKO]]></acronim><duration>10.12.2024 - 09.12.2027</duration><status>U tijeku</status><financ_value>199.999,99 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Interdisciplinarne prirodne znanosti, Kemija, Biologija, Geofizika, </scie_field_hr><scie_field_en>Interdisciplinary natural sciences, Chemistry, Biology, Geophysics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>290, 1155, 865334, 856281, 868116, 23222, 25748, 22603, 867607, 872986, </team_members_id><team_members_names><![CDATA[Marija Marguš, Jelena Dautović, Iva Dominović Novković, Niki Simonović, Georgiy Kirillin, Andrea Budiša, Sarah Mateša, Blanka Milić Roje, Nikola Zdolšek, Luka Andrijanić, ]]></team_members_names><keywords_hr><![CDATA[stabilni izotopi, organska tvar, CNS omjer, stratifikacija, morsko jezero, Rogozničko jezero-Zmajevo oko ]]></keywords_hr><keywords_en><![CDATA[stable isotopes, organic matter, CNS ratio, stratification, sea lake, Rogozničko lake-Zmajevo oko]]></keywords_en><summary_hr><![CDATA[Projekt ISO-ZOKO, kao prošireni nastavak projekta MARRES, ima za cilj istražiti varijabilnost sastava stabilnih izotopa (13C, 15N, 34S) i C/N/S omjera organske tvari (OT) u različitim vodenim slojevima morskog sustava Rogozničkog jezera (RL) – Zmajeva oka, s posebnim osvrtom na hipooksigenirani epilimnion te euksinski sloj kemokline i monimolimniona. Stabilni izotopi će se proučavati zajedno s drugim relevantnim pokazateljima podrijetla i sudbine OT s obzirom na fizikalno-kemijsku stabilnost vodenog stupca RL i moguće vlažne i suhe unose oborinom, putem peludi, površinskog otjecanja i krške podzemne vode. Glavni cilj projekta je razlikovati različite alohtone i autohtone izvore i karakteristike OT u ovom stratificiranom i eutrofnom morskom okolišu. Važan cilj, ali i ishod projekta je postavljanje stalne motriteljske stanice s data loggerima za kontinuirano mjerenje fizikalno-kemijskih parametara (T, S, O2, pH) visoke prostorne i vremenske rezolucije u centru jezera, nad njegovom najdubljom točkom. Mjerna postaja bit će važan izvor podataka za praćenje suptilnih promjena u raslojenosti vodenog stupca u kontekstu ovog projekta, ali i u budućnosti za sve zainteresirane za limnološka i/ili istraživanja promjenjivih uvjeta okoliša. Ovakva istraživanja u vrijeme intenzivnih klimatskih i ekoloških promjena imaju vrlo važan lokalni, ali i širi znanstveni utjecaj.Rezultati projekta značajno će doprinijeti: 1) poznavanju izvora, sudbine i ciklusa OT u obalnim sredinama kao što su plitki zaljevi, lagune i morska jezera, kao i 2) sustavnom praćenju, održivom korištenju, zaštiti i upravljanju takvim okolišem, a posebno zaštiti ovog klimatskim promjenama i antropogenim utjecajima ugroženom sustavu jadranske obale. Važan doprinos projekta je i u jačanju istraživačkih kapaciteta i suradnje unutar komplementarne i interdisciplinarne istraživačke grupe, uključujući osposobljavanje i obrazovanje mladih znanstvenika.]]></summary_hr><summary_en><![CDATA[The ISO-ZOKO project, as an extended continuation of the MARRES project, aims to investigate the variability of stable isotope signatures (13C, 15N, 34S) and C/N/S ratios of organic matter (OM) in different water layers of the Rogoznica Lake (RL) - Zmajevo oko marine system, with special focus on the hypooxygenated epilimnion and the euxinic chemocline and monimolimnion. Stable isotopes will be studied together with other relevant proxies as indicators of the origin and fate of OM with respect to the physico-chemical stability of the RL water column and possible wet and dry inputs from precipitation, pollen, surface runoff and karst groundwater. The main objective is to distinguish between different allochthonous and autochthonous sources and characteristics of OM in this highly stratified marine environment. An important goal, but also the outcome of this project, is the installation of a permanent station for continuous monitoring of the physico-chemical parameters (T, S, O2, pH) with high spatial and temporal resolution in the centre, above the deepest point of the lake. The measuring station will be an important data source for monitoring subtle changes in the stratification of the water column not only within this project, but also in the future for all those interested in limnological and/or research on changing environmental conditions. Such research in times of intense climatic and ecological change has a very important local but also broader scientific impact.The project results will contribute significantly to the knowledge of the sources, fate and cycling of OM in coastal environments such as shallow bays, lagoons and marine lakes, as well as to the systematic monitoring, sustainable use, protection and management of RL and similar marine systems. An important contribution is seen in the strengthening of research capacity and collaboration within the complementary and interdisciplinary research group, including the training of young researchers.]]></summary_en></project><project>
<id>16908</id><title_hr><![CDATA[Između znanja i neznanja: ideje, prakse i nasljeđe prosvjetiteljstva u hrvatskim zemljama]]></title_hr><title_en><![CDATA[Between Knowledge and Ignorance: Ideas, Practices, and the Legacy of the Enlightenment in Croatian Lands]]></title_en><user_id>1124</user_id><user_firstLast_name>Teodora Shek Brnardić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2024-05</proposal_call><code>IP-2024-05-5581</code><acronim><![CDATA[LIGHT]]></acronim><duration>16.12.2024 - 15.12.2027</duration><status>U tijeku</status><financ_value>135.640,00 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Povijest, Filologija, </scie_field_hr><scie_field_en>History, Philology, </scie_field_en><institution_hr><![CDATA[Hrvatski institut za povijest]]></institution_hr><institution_en><![CDATA[Croatian Institute of History]]></institution_en><team_members_id>888, 23699, 868257, 19726, 868670, 868680, 872887, </team_members_id><team_members_names><![CDATA[Goranka Šutalo, Zrinko Novosel, Stipe Ledić, Katja Radoš-Perković, Marta Jurković, Maja Perić, Matea Marušić, ]]></team_members_names><keywords_hr><![CDATA[prosvjetiteljstvo, povijest knjige, katoličko prosvjetiteljstvo, hrvatska povijest, cirkulacija znanja, Francuska revolucija]]></keywords_hr><keywords_en><![CDATA[Enlightenment, history of books, Catholic Enlightenment, Croatian history, circulation of knowledge, French Revolution]]></keywords_en><summary_hr><![CDATA[Cilj projekta je mapirati i identificirati obilježja i geografiju prosvjetiteljstva kao intelektualnog pokreta i kulturnog procesa koji je značajno oblikovao moderno doba u kontekstu hrvatskih zemalja u &#39;&#39;dugom&#39;&#39; 18. stoljeću. Iako su prosvjetiteljstvo i njegovo nasljeđe kao predmet istraživanja uvelike prisutni u svjetskoj historiografiji, hrvatska perspektiva na ovu temu uglavnom je neistražena. Stoga projekt LIGHT nastoji ispraviti ovaj znanstveni propust fokusirajući se po prvi put na prosvjetiteljski diskurs unutar hrvatskih konteksta (civilna Hrvatska, Slavonija, Dalmacija i Dubrovačka Republika). Tijekom trogodišnjeg razdoblja, istraživački će tim, prvo, interdisciplinarno analizirati prethodne interpretacije i konceptualizacije prosvjetiteljstva u hrvatskim zemljama i Europi preko odabranih studija slučaja. Drugo, istraživanje će učiniti vidljivima neke ključne aktere hrvatskog prosvjetiteljstva i njihove transnacionalne intelektualne mreže. Treće, bit će odabrani karakteristični izvorni tekstovi hrvatskih prosvjetitelja koji će služiti kao polazište za buduća istraživanja. Tematska područja obuhvaćat će &#39;&#39;katoličko prosvjetiteljstvo&#39;&#39;, &#39;&#39;cirkulaciju prosvjetiteljskog znanja&#39;&#39; i &#39;&#39;prosvjetiteljstvo i revoluciju&#39;&#39;. Rezultati projekta uključivat će niz izvješća, anotiranih bibliografija, znanstvenih radova, prvu doktorsku disertaciju na temu prosvjetiteljstva u hrvatskim zemljama, te kreiranje prve digitalne čitanke tekstova hrvatskog prosvjetiteljstva. Nadalje, tim namjerava organizirati tri radionice i doktorski okrugli stol kako bi potaknuo akademsku raspravu i daljnju suradnju u ovom području.]]></summary_hr><summary_en><![CDATA[The aim of the project is to map and identify the features and geography of the Enlightenment as both an intellectual movement and cultural process that significantly shaped the modern era within the context of Croatian lands in the &#39;&#39;long&#39;&#39; 18th century. While the Enlightenment and its legacy have been extensively studied in world historiography, the Croatian perspective on this subject remains largely unexplored. Consequently, the LIGHT project endeavours to rectify this scholarly oversight by focusing on the Enlightenment discourse within Croatian contexts (Civil Croatia, Slavonia, Dalmatia, and Republic of Ragusa) for the first time. Over a three-year period, the research team will, firstly, undertake an interdisciplinary analysis of prior interpretations and conceptualizations of the Enlightenment across Croatian lands and Europe, drawing from selected case studies. Secondly, the investigation will highlight some key actors of the Croatian Enlightenment and explore their transnational intellectual networks. Thirdly, the team will compile a collection of original texts authored by the Croatian Enlightenment actors, which will serve as foundational resources for future scholarship. The thematic focus areas encompass &#39;&#39;the Catholic Enlightenment,&#39;&#39; &#39;&#39;the circulation of Enlightenment knowledge,&#39;&#39; and &#39;&#39;the Enlightenment and revolution.&#39;&#39; The project&#39;s outcomes will include a series of scholarly reports, annotated bibliographies, scientific papers, a pioneering doctoral dissertation on the Croatian Enlightenment, and the creation of a digital reader featuring primary texts by key actors. Furthermore, the team intends to convene three workshops and a doctoral roundtable to foster academic discourse and further collaboration in this field. ]]></summary_en></project><project>
<id>16919</id><title_hr><![CDATA[Razvoj drvenih obloga s integriranim električnim grijanjem]]></title_hr><title_en><![CDATA[Development of wood covering elements with integrated electric heating]]></title_en><user_id>20467</user_id><user_firstLast_name>Vjekoslav Živković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2024-05</proposal_call><code>IP-2024-05-9506</code><acronim><![CDATA[GRIpod]]></acronim><duration>19.12.2024 - 18.12.2027</duration><status>U tijeku</status><financ_value>197.685,00 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Drvna tehnologija, Interdisciplinarne biotehničke znanosti, </scie_field_hr><scie_field_en>Wood technology, Interdisciplinary biotechnical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet šumarstva i drvne tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Forestry and Wood Technology]]></institution_en><team_members_id>868252, 20496, 868112, 868277, 5971, 867966, 868273, </team_members_id><team_members_names><![CDATA[Andrija Novosel, Hrvoje Turkulin, Goran Mihulja, Josip Miklečić, ANDREJA PIRC BARČIĆ, Tomislav Gržan, Tomislav Sedlar, ]]></team_members_names><keywords_hr><![CDATA[drvene obloge, električno grijanje, stabilnost, integracija, prenosivost]]></keywords_hr><keywords_en><![CDATA[wood coverings, electric heating, stability, integration, portability]]></keywords_en><summary_hr><![CDATA[Cilj ovog projekta je razviti novi sustav grijanja integriranog u drvene podne ili zidne obloge. Ovo primijenjeno istraživanje je organizirano kroz 6 radnih cjelina u svrhu ostvarenja sljedećih ciljeva: C1. istražiti mogućnost izrade prenosivog – rastavljivog sustava grijanja integriranog u drvenu oblogu, C2. ujednačiti distribuciju topline po površini lica i presjeku uzorka, C3. razumjeti međudjelovanje komponenti kompozita, C4. izraditi dimenzijski stabilan proizvod drvene obloge uslijed promjenjivih klimatskih uvjeta, neovisno o kombinaciji materijala i vrsta drva, C5. izraditi funkcionalnu plohu od većeg broja elemenata s integriranim grijaćim komponentama, C6. procijeniti životni ciklus proizvoda (engl. Life cycle assesment, LCA).GRIpod sustav ima za cilj umanjiti ili potpuno eliminirati nedostatke postojećih rješenja i osigurati jednoliku distribuciju topline po cijeloj površini, omogućiti ponovnu upotrebu proizvoda, osigurati finu regulaciju temperature te racionalno korištenje električne energije. Ljepila za integraciju slojeva obloge osiguravaju postojanost proizvoda u uvjetima povećane temperature površine te integraciju sustava grijanja u drveni sklop.Preliminarni i još uvijek neobjavljeni rezultati vlastitog pokusa pokazuju velik potencijal predloženog sustava. GRIpod zadovoljava suvremene potrebe stanara te im, osim male potrošnje energije i visoke ugode korištenja po potrebi omogućuje premještanje sustava i ponovnu uporabu bez dodatnih troškova. Prednost ovog jedinstvenog sustava očituje se u značajnom smanjenju troškova i nepovoljnog utjecaja na okoliš zahvaljujući izostanku potrebe za dodatnim kotlovima, instalacijskim cijevima i dodatnim grijaćim tijelima koja zauzimaju prostor. Dodatna prednost sustava GRIpod je i izostanak rizika od havarije uzrokovane mogućom poplavom iz sustava grijanja na toplu vodu, te jednostavna regulacija i odvojeno upravljanje po pojedinim prostorijama.]]></summary_hr><summary_en><![CDATA[The aim of this project is to develop a new heating system integrated into wood floor or wall coverings. This applied research is organized through 6 work packages in order to achieve the following objectives: O1. to investigate the possibility of creating a portable - demountable heating system integrated in wood elements, O2. equalize the distribution of heat over the surface of the face and cross-section of the sample, O3. understand the interaction of components, O4. create a dimensionally stable wood product despite its installation in changing climatic conditions, O5. create a functional unit composed of large number of elements with integrated heating components, O6. to investigate life cycle assessment of the product (LCA).The GRIpod system aims to reduce or completely eliminate the shortcomings of existing solutions and ensure uniform distribution of heat over the entire surface, enable product reuse, ensure fine temperature regulation and rational use of electrical power. Adhesives for the integration of the layers ensure product stability in conditions of increased surface temperature and the integration of the heating system into the wooden assembly.The preliminary and still unpublished results of our own experiment show the great potential of the proposed system. GRIpod meets the modern needs of tenants and, in addition to low energy consumption and high comfort of use, enables them to move the system and reuse it if necessary without additional costs. The advantage of this unique system is manifested in a significant reduction of costs and adverse environmental impact thanks to the absence of the need for additional boilers, installation pipes and additional heating elements that take up space. An additional advantage of the GRIpod system is the absence of the risk of a breakdown caused by a possible flood from the hot water heating system, as well as simple regulation and separate management for individual rooms.]]></summary_en></project><project>
<id>16925</id><title_hr><![CDATA[Elektromagnetska karakterizacija bioloških tkiva i stanica za medicinske i biološke primjene]]></title_hr><title_en><![CDATA[Electromagnetic characterization of biological tissues and cells for medical and biological applications]]></title_en><user_id>7748</user_id><user_firstLast_name>Antonio Šarolić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2024-05</proposal_call><code>IP-2024-05-5576</code><acronim><![CDATA[EMF-Med]]></acronim><duration>16.12.2024 - 15.12.2027</duration><status>U tijeku</status><financ_value>199.999,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Fakultet elektrotehnike, strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Electrical Engineering, Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>23271, 27082, 4000, 122, 23267, 873029, </team_members_id><team_members_names><![CDATA[Ivan Marinović, Anđela Matković, Damir Sapunar, Vedrana Čikeš Čulić, Anton Kordić, Viktoria Pavlovski, ]]></team_members_names><keywords_hr><![CDATA[radiofrekvencijska i mikrovalna elektromagnetska polja, permitivnost, biološka tkiva i stanice, biomarkeri, senzori, medicinske i biološke primjene]]></keywords_hr><keywords_en><![CDATA[RF and microwave electromagnetic fields, permittivity, biological tissues and cells, biomarkers, sensors, medical and biological applications]]></keywords_en><summary_hr><![CDATA[Dielektrična permitivnost materijala je fizikalni parametar koji određuje način interakcije materijala s elektromagnetskim poljem u radiofrekvencijskom odnosno mikrovalnom frekvencijskom području. U sklopu ovog projekta planirana je elektromagnetska  karakterizacija bioloških tkiva, zdravih i patoloških, koreliranjem njihove permitivnosti s biokemijskim parametrima tkiva, odnosno sadržajem vode i drugih sastojaka u tkivu. Uz tako uspostavljenu korelaciju, permitivnost može poslužiti kao značajan biomarker u medicinskim i biološkim primjenama. Kao primjer medicinski značajnog biomarkera i pridružene aplikacije, u projektu je planiran razvoj prototipa neinvazivnog i nedestruktivnog elektroničkog senzora dielektričnog kontrasta za intraoperativnu diskriminaciju meningeoma od okolnog zdravog tkiva. Uz elektromagnetsku karakterizaciju na razini tkiva, provest će se i analiza permitivnosti populacije stanica u staničnoj kulturi. Izmjerena permitivnost korelirat će se s elektrofiziološkim parametrima pojedinačnih stanica iz populacije, kao i s općenitim fiziološkim stanjem populacije u vidu broja stanica i njihove vijabilnosti. Kao primjer biomedicinski značajnog biomarkera i pridružene aplikacije, u projektu je planiran razvoj prototipa neinvazivnog i nedestruktivnog elektroničkog senzora permitivnosti za kontinuirani nadzor bioloških parametara, prvenstveno vijabilnosti populacije stanica u staničnoj kulturi. U projektu će se koristiti inženjerske metode elektromagnetske analize simulacijama i mjerenjima, paralelno s analitičkim biokemijskim metodama i elektrofiziološkim metodama koje se koriste u biomedicinskim istraživanjima tkiva i stanica. U tom smislu projekt je vrlo interdisciplinaran, s konačnim rezultatima iz područja elektroničkih i elektromagnetskih senzora, ali s primjenom u medicini i biologiji. ]]></summary_hr><summary_en><![CDATA[Dielectric permittivity of a material is a physical parameter determining its interaction with electromagnetic field in the radiofrequency and microwave frequency range. Within this project we plan to electromagnetically characterize biological tissues, both healthy and pathological, by correlating their permittivity with their biochemical parameters, i.e. relative content of water and other tissue constituents. Based on such established correlation, permittivity can serve as a significant biomarker in medical and biological applications. As an example of a medically significant biomarker and the associated application, the project plans to develop a prototype of a non-invasive and non-destructive permittivity contrast sensor, applicable for intraoperative discrimination between meningioma tissue and the surrounding healthy tissues. Besides the electromagnetic characterization on the tissue level, the project will also analyze the permittivity of cell population in a cell culture. The measured permittivity will be correlated with the electrophysiological parameters of individual cells from the population, and with the general physiological state of the population in terms of cell count and cell viability. As an example of a biomedically significant biomarker and the associated application, the project plans to develop a prototype of a non-invasive and non-destructive permittivity sensor for continuous monitoring of cell culture biological parameters, primarily the cell viability in the cell culture. The project will use the engineering methods of electromagnetic analysis using simulations and measurements, in parallel with the analytical biochemistry methods and electrophysiology methods, used in the biomedical research on tissues and cells. Accordingly, the project is highly interdisciplinary, with the final results within the field of electronic and electromagnetic sensors, albeit with the application in medicine and biology.]]></summary_en></project><project>
<id>16931</id><title_hr><![CDATA[Razvoj rječnika djece mlađe školske dobi kroz inovativne estetske i utjelovljene metode učenja]]></title_hr><title_en><![CDATA[Vocabulary development of younger school-age children through innovative aesthetic and embodied learning methods]]></title_en><user_id>5121</user_id><user_firstLast_name>Katarina Aladrović Slovaček</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2024-05</proposal_call><code>IP-2024-05-8350</code><acronim><![CDATA[RjeŠko]]></acronim><duration>16.12.2024 - 15.12.2027</duration><status>U tijeku</status><financ_value>145.800,00 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filologija, Interdisciplinarne humanističke znanosti, </scie_field_hr><scie_field_en>Philology, Interdisciplinary humanities, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Učiteljski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Teacher Education]]></institution_en><team_members_id>13059, 29197, 26787, 26365, 6147, 866382, 868304, 868299, 23238, 23337, 23324, 868296, 868424, 7052, 865957, </team_members_id><team_members_names><![CDATA[Monika Pažur, Anđela Milinović Hrga, Tamara Turza-Bogdan, Igor Marko Gligorić, Gordana Hržica, Irena Krumes, Luka Petrač, Josipa Kraljić, Maša Rimac Jurinović, Jelena Vignjević, Ana Ćavar, Tihana Bilešić, DUNJA PAVLIČEVIĆ-FRANIĆ, Lidija Cvikić, Jelena Parizoska Parizoska, ]]></team_members_names><keywords_hr><![CDATA[ hrvatski jezik, školski rječnik, pedagoški korpus, intervencijski program, leksička kompetencija]]></keywords_hr><keywords_en><![CDATA[Croatian language, school dictionary, pedagogical corpus, intervention program, lexical competence]]></keywords_en><summary_hr><![CDATA[Leksički razvoj najdinamičniji je dio jezičnoga razvoja te je cijeloga života podložan čestim kvantitativnim i kvalitativnim promjenama koje su u određenim vremenskim razdobljima različitoga intenziteta. U predškolskoj dobi leksički razvoj ovisi o izloženosti jezičnome unosu, govornoj komunikaciji i kognitivnim odlikama djeteta, dok se značajniji napredak događa polaskom u školu kada se naglo povećava broj usvojenih riječi, širi se znanje o tvorbi riječi te se usavršava sposobnost učenja novih riječi iz konteksta. Prema procjenama rječnik sedmogodišnjeg djeteta opseže od 10000 do 13000 riječi i proporcionalno se povećava, pa u 3. razredu iznosi otprilike 19000 riječi, a u 5. razredu već oko 40000 riječi. Na proces ovladavanja rječnikom utjecat će brojni jezični čimbenici, ali jednako tako i oni izvanjezični. Najveći broj novih riječi dijete usvoji čitanjem, i to ponajprije različitih tekstova u udžbenicima, ali i lektirnim djelima. Jednako tako, svjesni smo činjenice kako se današnje generacije sve teže izražavaju te im vrlo često nedostaje riječi kojima bi izrazili svoje misli, želje ili osjećaje. Iako se čitanjem prosječan osnovnoškolac godišnje susreće s dvije do tri tisuće novih riječi, samo 20 % njih postaju dijelom njegova umnoga leksikona. Međutim, ne postoje sustavna istraživanja školskoga rječnika na korpusu hrvatskoga jezika te posljedično niti mjere i načini propitivanja leksičke kompetencije mada se od učitelja očekuje da usmene i pisane radove učenika vrednuje i s obzirom na bogatstvo rječnika. Stoga je temeljni cilj ovoga projektnoga prijedloga razviti i validirati testove leksičke kompetencije za učenike mlađe školske dobi te razviti dva intervencijska odgojno-obrazovna programa koji inovativnim estetskim i utjelovljenim metodama učenja potiču bogaćenje rječnika, a u čijoj će validaciji uz učenike sudjelovati i učitelji i roditelji.  ]]></summary_hr><summary_en><![CDATA[Lexical development is the most dynamic part of language development and is under the influence of frequent quantitative and qualitative changes happening in our life in  various intensity at different periods. At preschool age lexical development depends on the language input, spoken communication and cognitive characteristics of a child, whereas significant progress takes place when a child starts school since the number of acquired words increases to a great extent, word formation knowledge expands and the ability to learn words from the context also improves. According to estimates, a seven-year-old&#39;s vocabulary contains 10000 to 13000 words and increases proportionally so that in the third grade it contains about 19000 words and in the fifth grade already about 40000 words. Not just numerous linguistic factors but extra-linguistic as well influence the vocabulary acquisition process. A child acquires most new words reading, both various textbook texts and obligatory literary works. We are equally aware of the fact that the today&#39;s children find it increasingly difficult to express themselves and often lack words to articulate their thoughts, desires or feelings. Even though an average primary school child encounters two to three  thousand new words per year, only 20% become part of his/her mental lexicon. However, there is no systematic research of the school vocabulary on the corpus of Croatian language and as a consequence there is no assessment or ways of examining lexical competence even though teachers are expected to assess spoken and written texts that students produce with regard to vocabulary richness as well. It is therefore the primary goal of this project to develop and validate younger school children&#39;s lexical competence tests and to develop two interventional educational programs to encourage vocabulary development through innovative esthetic and embodied methods, that will be validated not only by students but also by teachers and parents.   ]]></summary_en></project><project>
<id>16932</id><title_hr><![CDATA[Ljudski prenatalni cerebralni neksus: neistražen prostorno-vremenski višerazmjerni kompartmentalni translacijski pristup]]></title_hr><title_en><![CDATA[Human prenatal cerebral nexus: uncharted spatiotemporal multiscale compartmental translational approach]]></title_en><user_id>12951</user_id><user_firstLast_name>Ivica Kostović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2024-05</proposal_call><code>IP-2024-05-7157</code><acronim><![CDATA[HUMANCOMPARTMENTOME]]></acronim><duration>09.12.2024 - 08.12.2027</duration><status>U tijeku</status><financ_value>198.800,00 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, Clinical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>3523, 7740, 4298, 855745, 855327, 3483, 865657, 2549, 872893, </team_members_id><team_members_names><![CDATA[Mario Vukšić, Miloš Judaš, Milan Radoš, Janja Kopić, Jelena Božek, Sanja Darmopil, Fran Božić Božić, Ana Hladnik, Marta Vidas, ]]></team_members_names><keywords_hr><![CDATA[mozak fetusa čovjeka, kortikogeneza, prolazni sinaptički odjeljci, prematurus, translacija]]></keywords_hr><keywords_en><![CDATA[human fetal brain, corticogenesis, transient synaptic compartments, premature infants, translation]]></keywords_en><summary_hr><![CDATA[Glavni cilj je sinteza i integracija vremensko-prostornih pokazatelja histogenetskih događaja u prolaznim laminarnim odjeljcima mozga na višerazmjernim skalama razlučivanja (od nanoskale EM do makroskale na MR) i dovesti te parametre u prostorni odnos s razmještajem talamokortikalnih neuronskih veza: sinapsa, presinaptičkih aksona i postsinaptičkih elemenata u SP (subplate), CP (kortikalna ploča) i MZ (marginalna zona). Ti ciljevi povezani su preko vremensko-prostornih parametara, staničnih događanja (proliferacija, migracija, molekularna specifikacija, razvitak fenotipa, rast aksona, sinaptogeneza) koji se događaju u prolaznim histogenetskim odjeljcima i mogu se prikazati putem in vivo MR. Razvitak talamokortikalnih veza do somatosenzoričkog, cingularnog i prekunealnog korteksa i nucleus basalis bit će analiziran s pomakom imunoreaktivnosti na sinaptičke proteine od intraaksonalne reakcije preko SP do CP između 22 i 26 postkoncepcijskih tjedana. Istražit će se korelacija tog procesa s MR. Kao rezultat, očekujemo nova razvojna bodovanja usmjerena na neuronske veze i promjenjivu temeljnu arhitekturu fetalnog korteksa, osobito tijekom razdoblja prematuriteta. Novi višerazmjerni pristup od EM do MR temelji se na analizi postojećih uzoraka Zagrebačke neuroembriološke zbirke i razvojne baze MR podataka i važan je da se premosti znanje o razvitku humanog konektoma i ekspresije genskih putanja na jednoj strani te nedostatnih podataka o uključenosti sinapsi na drugoj strani. Novo razvojno bodovanje normotipičnih prematurusa koristit će naši klinički partnerima longitudinalno praćenje skupina djece, koja su obuhvaćena prethodnim HRZZ projektima. Implementacija novog razvojnog bodovanja pomoći će u bitnom razlikovanju organizacije mozga u ranim i kasnim skupinama prematurusa i pomoći u rasvjetljavanju uzroka, ranoj dijagnozi i ciljanom habilitacijskom tretmanu neurorazvojnih  poremećaja. ]]></summary_hr><summary_en><![CDATA[Main goal is the synthesis and integration of spatio-temporal indicators of histogenetic events in transient laminar brain compartments on multilevel resolution scales (from nanoscale EM to macroscale on MR) and bring these parameters into a spatial relationship with thalamocortical neuronal connectivity distribution: synapses, presynaptic axons and postsynaptic elements in SP (subplate), CP (cortical plate) and MZ (marginal zone). These goals are connected through spatio-temporal parameters, cellular events (proliferation, migration, molecular specification, phenotype development, axon growth, synaptogenesis) that occur in transient histogenetic compartments and can be shown by in vivo MR. Development of thalamocortical connections to the somatosensory, cingulate and precuneal cortex and the nucleus basalis will be analyzed with shift of immunoreactivity of synaptic proteins from intra-axonal reaction via SP to CP between 22 and 26 postconceptional weeks.Correlation of this process with MR will be investigated. As a result, we anticipate new developmental scoring targeting neural connections and changing underlying architecture of fetal cortex, particularly during period of prematurity. New multiscale approach from EM to MR is based on analysis of existing samples of the Zagreb Neuroembryological Collection and developmental MR database and is important to bridge the knowledge about development of human connectome and gene pathway expression on the one hand and insufficient data on involvement of synapses on the other. The new developmental scoring of normotypical premature infants will be used by clinical partners for longitudinal monitoring of groups of children, which were included in previous CSF projects. Implementation of new developmental scoring will help significantly in differentiating organization of brain in early and late preterm infants and help in elucidating causes, early diagnosis and targeted habilitation treatment of neurodevelopmental disorders.]]></summary_en></project><project>
<id>16942</id><title_hr><![CDATA[Sinteza novih benzazolnih heterocikla kao potencijalnih antitumorskih i antibakterijskih agensa]]></title_hr><title_en><![CDATA[Synthesis of new benzazole heterocycles as potential antitumor and antibacterial agents]]></title_en><user_id>2914</user_id><user_firstLast_name>Marijana Hranjec</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2024-05</proposal_call><code>IP-2024-05-7208</code><acronim><![CDATA[BenzHetPot ]]></acronim><duration>16.12.2024 - 15.12.2027</duration><status>U tijeku</status><financ_value>200.000,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, Biologija, </scie_field_hr><scie_field_en>Chemistry, Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet kemijskog inženjerstva i tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Chemical Engineering and Technology]]></institution_en><team_members_id>2865, 25735, 867203, 26992, 23747, 1099, 865646, 865623, 25986, 869853, 872903, </team_members_id><team_members_names><![CDATA[Livio Racane, Ida Boček Pavlinac, Marina Galić, Anja Beč, Kristina Butković, Ivana Novak Jovanović, Dirk Daelemans, Mihailo Banjanac, Vedrana Radovanović, Antonija Mamić, Jurja Vukovinski, ]]></team_members_names><keywords_hr><![CDATA[benzazoli, heterocikli, zelena kemija, antitumorska aktivnost, antibakterijska aktivnost]]></keywords_hr><keywords_en><![CDATA[benzazoles, heterocycles, green chemistry, antitumor activity, antibacterial activity]]></keywords_en><summary_hr><![CDATA[Predloženi istraživački projekt usmjeren je na dizajn, sintezu i strukturnu karakterizaciju novih derivata benzazola kao potencijalnih agensa s antitumorskim i antibakterijskim djelovanjem. Projekt je izrazito multidisciplinaran i okuplja interdisciplinarni tim od 10 istraživača čija će zajednička sinergija dovesti do postizanja glavnih ciljeva projekta. Projekt će se sastojati od tri glavna cilja uključujući sintezu i strukturnu karakterizaciju derivata benzazola, optimiranje i razvoj novih zelenih sintetskih metoda te biološka ispitivanja. U sklopu projekta provest će se sinteza biblioteke različitih benzazola, a dodatno bi ovo zajedničko istraživanje trebalo rezultirati optimiranjem strukture benzazolne jezgre što će osigurati bolju učinkovitost, aktivnost, selektivnost i optimirana fizikalno-kemijska i biološka svojstva u potrazi za predvodnim spojevima. Strukturno optimiranje kao i proučavanje biološkog djelovanja provest će se i pomoću računalne kemija. Biološka ispitivanja uključivat će in vitro testove za procjenu antiproliferativne i antibakterijske aktivnosti. Odabranim najaktivnijim spojevima ispitat će se u dodatnim eksperimentima određivanja antitumorskog i/ili antibakterijskog djelovanja i mehanizmi njihovog biološkog djelovanja odabirom specifičnih bioloških meta. Kako bi se dobio bolji uvid u mehanizme djelovanja predvodnih spojeva, provodit će se i elektrokemijska ispitivanja biološkog djelovanja te interakcija s DNA/RNA. Na temelju principa suvremenog pristupa lijekovima, proučavat će se korelacija i sinergija između spojeva s obećavajućim antitumorskim i antibakterijskim djelovanjem. Konačno, opisano istraživanje temelji se na zajedničkom istraživanju nekoliko različitih institucija uključujući istraživače iz različitih znanstvenih područja. Predloženi projekt temelji se na istraživanjima u području medicinske kemije s naglaskom na moguća daljnja ciljana istraživanja kao i daljnji razvoj naše znanstvene grupe na međunarodnoj razini.]]></summary_hr><summary_en><![CDATA[The proposed research project is oriented towards the design, synthesis, and structural characterization of novel benzazoles as promising agents with antitumor and antibacterial activity. The project is highly multidisciplinary and brings together an interdisciplinary team of 10 researchers whose common synergy will lead to the achievement of the main project goals and objectives. The project will consist of three main objectives including synthesis and structural characterization of benzazole derivatives, optimization and development of novel green synthetic methods and biological evaluation. Within the project synthesis of benzazole library will be achieved, while this collaborative research should result in the optimization of the benzazole structural core which will ensure better efficiency, activity, selectivity, and optimized physico-chemical and biological properties in the search for lead compounds. Structural optimization and studying of the biological action will be aided by computational chemistry. Biological evaluation will include in vitro evaluation of antiproliferative and antibacterial activity. The chosen most active compounds will be evaluated in additional antitumor and antibacterial assays to study their mechanisms of biological action by choosing specific biological targets. To get more insight into the mechanisms of action of lead compounds, the electrochemical evaluation of the biological action and interaction with DNA/RNA will be studied. Based on the principles of modern drug approach, the correlation and synergy between compounds with promising antitumor and antibacterial activity will be studied. Finally, the presented research is based on joint research of different institutions including researchers from different scientific fields. Proposed project is based on the research in the field of medicinal chemistry with focus on possible further target research and further development of our scientific group on the international level.]]></summary_en></project><project>
<id>16952</id><title_hr><![CDATA[Genomika i epigenomika holocentromera u nematoda Meloidogyne]]></title_hr><title_en><![CDATA[Genomics and epigenomics of holocentromeres in nematodes Meloidogyne]]></title_en><user_id>5779</user_id><user_firstLast_name>Nevenka Meštrović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2024-05</proposal_call><code>IP-2024-05-2675</code><acronim><![CDATA[HOLOCEN]]></acronim><duration>20.12.2024 - 19.12.2027</duration><status>U tijeku</status><financ_value>199.525,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>332, 868033, 21387, 3128, 868031, </team_members_id><team_members_names><![CDATA[Brankica Mravinac, Ana Paula Zotta Mota, Evelin Despot-Slade, Raul Horvat, Etienne GJ Danchin, ]]></team_members_names><keywords_hr><![CDATA[holocentromere, linearna organizacija, epigenetski biljezi, komparativne genomske analize, Meloidogyne]]></keywords_hr><keywords_en><![CDATA[holocentromere, long-range organization, epigenetic marks, comparative genome analyses, Meloidogyne]]></keywords_en><summary_hr><![CDATA[Centromera je kompleksni kromosomski lokus koji ima jednu od najvažnijih uloga u procesu segregacije kromosoma. Abnormalnosti u ovoj regiji uzrokuju brojne poremećaje poput stanične smrti, aneuploidije, neplodnosti i raka. Iako centromere imaju očuvanu funkciju, histon H3 specifičan za centromere (CenH3) i centromerna DNA brzo se mijenjaju. Dok većina eukariota ima jednu regionalnu centromeru, neke biljne i životinjske vrste imaju holocentromere raspoređene na više mjesta duž kromosoma. Organizacija genoma i sastav kromatina holocentričnih kromosoma slabo su poznati. Naši prethodni rezultati upućuju na jedinstvenu organizaciju holocentromera u formi klastera i dupliciranje CenH3 gena specifičnog za centromere u mitotičkim i mejotičkim nematodama roda Meloidogyne. Prvi cilj ovog prijedloga je istražiti linearnu organizaciju, genomsku dinamiku i okolinu holocentromera u vrsti Meloidogyne incognita i njezinim srodnicima, korištenjem novih genomskih sklopova sekvenciranih dugim očitanjima. Pojavljivanje dva CenH3 paraloga u mejotičkim vrstama Meloidogyne ukazuje na mogućnost subfunkcionalizacije CenH3 paraloga. U tom smislu, drugi cilj ovog projekta je otkriti pretpostavljenu razliku između strukture holocentričnog CenH3 kromatina u mitozi i mejozi kod mejotičkih vrsta roda Meloidogyne. Moguća subspecijalizacija CenH3 za mitozu i mejozu kod vrsta Meloidogyne pruža jedinstvenu priliku za razumijevanje funkcija CenH3 u centromere. Osim istraživanja genomskih i epigenomskih karakteristika holocentromera, naša će studija također rasvijetliti moguće aspekate arhitekture i evolucije genoma koji su pod utjecajem organizacije ovih neobičnih centromera. ]]></summary_hr><summary_en><![CDATA[The centromere is a complex chromosomal locus that plays one of the most important roles in the process of chromosome segregation. Abnormalities in this region cause numerous disorders such as cell death, aneuploidy, infertility and cancer. Although centromeres have a conserved function, centromere-specific histone H3 (CenH3) and centromeric DNA are rapidly evolving. While most eukaryotes have a single regional centromere, some plant and animal species have holocentromeres distributed at multiple sites along the chromosome length. The genome organization and chromatin composition of holocentric chromosomes are poorly understood. Our previous results suggest a unique cluster-like organization of holocentromeres and the duplication of a centromere-specific CenH3 gene in both mitotic and meiotic Meloidogyne nematodes. The first aim of this proposal is to investigate the long-range organization, genome dynamics and environment of the holocentromere in Meloidogyne incognita and its congenerics using the new, long-reads based assemblies. The occurrence of two CenH3 paralogs in meiotic Meloidogyne species raises the possibility of subfunctionalization of CenH3 paralogs. Therefore, the second aim of the project is to reveal the putative difference between the CenH3 chromatin of the holocentromere in mitosis and meiosis using meiotic Meloidogyne species. The possible subspecialization of CenH3 in mitosis and meiosis in Meloidogyne species provides a unique opportunity to understand the functions of CenH3 in the centromere.  In addition to investigating the genomic and epigenomic properties of the holocentromere, our study will also shed light on different aspects of genome architecture and evolution that are influenced by the organization of the unusual centromere. ]]></summary_en></project><project>
<id>16955</id><title_hr><![CDATA[Nova generacija dentalnih kompozita: Integracija cinkom obogaćenih mezoporoznih bioaktivnih nanosfera za poboljšanje antibakterijskih svojstava]]></title_hr><title_en><![CDATA[Next-Generation Dental Composites: Integrating Zn-Doped Mesoporous Bioactive Nanospheres for Enhanced Antibacterial Properties]]></title_en><user_id>26045</user_id><user_firstLast_name>Danijela Marović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2024-05</proposal_call><code>IP-2024-05-2884</code><acronim><![CDATA[MEZONANO]]></acronim><duration>09.12.2024 - 08.12.2027</duration><status>U tijeku</status><financ_value>199.895,00 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo, Biotehničke znanosti, Prirodne znanosti, </scie_area_hr><scie_area_en>Biomedicine and health sciences, Biotechnical sciences, Natural sciences, </scie_area_en><scie_field_hr>Dentalna medicina, Fizika, Kemija, Biotehnologija u biomedicini, </scie_field_hr><scie_field_en>Dental medicine, Physics, Chemistry, Biotechnology in Biomedicine, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Stomatološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Dentistry]]></institution_en><team_members_id>7666, 26086, 26772, 19740, 27329, 868384, 26658, 26917, 868118, 867088, 868376, 868184, 868408, 4129, 11137, 868470, 868400, 868504, 873066, </team_members_id><team_members_names><![CDATA[Zrinka  Tarle, Matej Par, Vlatko Panduric, Eva Klarić, Višnja Negovetić Mandić, Aldo R. Boccaccini, Attin Thomas, Tobias Taubock, Phoebe Burrer, Havard J. Haugen, Elena Figuero, Maria Jose Marin Cuenda, Leire Virto, Mario Rakić, Antonija Tadin Tadin, Lucija Ratkovski, Nika Supina, Matea Macan, Marija Kelić, ]]></team_members_names><keywords_hr><![CDATA[bioaktivno staklo, kompoziti, stomatološki, cink, fluor, mezoporozne čestice]]></keywords_hr><keywords_en><![CDATA[bioactive glass, composites, dental, zinc, fluorine, mesoporous particles]]></keywords_en><summary_hr><![CDATA[Konvencionalnim dentalnim kompozitima nedostaju svojstva koja bi mogla spriječiti sekundarni karijes, kao što su svojstva remineralizacije, neutralizacije kiseline i antimikrobna svojstva. Kako bi se riješio ovaj problem, predložena je ugradnja bioaktivnog stakla u dentalne kompozite, jer ono može otpuštati ione koji potiču remineralizaciju zubne strukture. Cilj projekta je razviti funkcionalne dentalne kompozitne materijale kako bi se spriječio nastanak sekundarnog karijesa.Mezoporozne bioaktivne staklene nanosfere s cinkovim oksidom (Zn-MBGN) imaju antibakterijska svojstva i otpuštaju ione kalcija koji su neophodni za ponovnu izgradnju kristala apatita. U okviru projekta sintetizirat će se Zn-MBGN čestice s rastućim sadržajem cinkovog oksida (0, 1 i 5%) te dodati u eksperimentalne kompozite u rastućim udjelima od 1-7%, zadržavajući identičnu smolastu matricu i inertna punila, tako producirajući 12 eksperimentalnih kompozita. Sveobuhvatno istraživanje u 27 različitih testova pružit će informacije o njihovim brojnim fizičkim, kemijskim, mehaničkim i biološkim svojstvima te njihovoj učinkovitosti na zubima.Osim Zn-MBGN kompozita, u ovom projektu će se nastaviti istraživanje kompozitnih materijala s fluoridom obogaćenim bioaktivnim staklom niskog udjela natrija (F-BG), koje je uspješno razvijeno u prethodnom projektu.Razvoj dentalnih kompozitnih materijala koji sadrže čestice bioaktivnog stakla ima potencijal za poboljšanje dugoročnog uspjeha zubnih restauracija unaprjeđenjem antibakterijskih svojstava i promicanjem remineralizacije zubne strukture, uz zadržavanje stabilnih mehaničkih svojstava. Ovaj projektni prijedlog ocrtava sveobuhvatan pristup za razvoj i procjenu takvog kompozitnog materijala koji bi mogao imati značajan klinički učinak u području restaurativne dentalne medicine.]]></summary_hr><summary_en><![CDATA[Conventional resin-based composites lack properties that could prevent secondary caries, such as remineralising, acid-neutralising and antimicrobial properties. To solve this problem, the incorporation of bioactive glass into dental composites has been proposed, as it can release ions that promote remineralisation of the tooth structure. The aim of the project is to develop functional composite materials for dental restorations to prevent the occurrence of secondary caries.Mesoporous bioactive glass nanospheres with zinc oxide (Zn-MBGN) have antibacterial properties and release calcium ions, which are necessary for the reconstruction of apatite crystals. In the project, Zn-MBGN particles with increasing zinc oxide content (0, 1 and 5%) will be synthesised and incorporated in increasing proportions of 1-7% into experimental composites with identical resin matrix and inert fillers to produce 12 experimental composite materials. A comprehensive investigation in 27 different tests will provide information on numerous physical, chemical, mechanical and biological properties and their effectiveness on teeth in vitro.In addition, research into composite materials with fluoride-doped low sodium bioactive glass (F-BG), which was successfully developed in the previous project, will be continued in this project.The development of dental composite materials containing bioactive glass particles has the potential to improve the long-term success of dental restorations by enhancing antibacterial properties and promoting remineralisation of the tooth structure while maintaining stable mechanical properties. This project proposal outlines a comprehensive approach for the development and evaluation of such a composite material that could have significant clinical impact in the field of restorative dental medicine. ]]></summary_en></project><project>
<id>16963</id><title_hr><![CDATA[Transformacije, prijenos i stabilnost organokositrovih spojeva u morskom okolišu]]></title_hr><title_en><![CDATA[Transformations, mobility and persistence of organotin compounds in the marine environment]]></title_en><user_id>3584</user_id><user_firstLast_name>Martina Furdek Turk</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2024-05</proposal_call><code>IP-2024-05-1906</code><acronim><![CDATA[TransOTin]]></acronim><duration>10.12.2024 - 09.12.2027</duration><status>U tijeku</status><financ_value>197.225,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Interdisciplinarne prirodne znanosti, Geologija, Kemija, Biologija, </scie_field_hr><scie_field_en>Interdisciplinary natural sciences, Geology, Chemistry, Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>868095, 5901, 5324, 4198, 4415, 5151, 25883, </team_members_id><team_members_names><![CDATA[MONTIGNY Chrystelle, Goran Palijan, Ines Sviličić Petrić, Neven Cukrov, Maja Ivanić, Mavro Lučić, Ivna Vrana Špoljarić, ]]></team_members_names><keywords_hr><![CDATA[Tributilkositar (TBT), metilkositrovi spojevi (MeT), morski okoliš, zagađenje, sedimenti, razgradnja, metilacija, prijenos]]></keywords_hr><keywords_en><![CDATA[Trybutyltin (TBT), methyltin compounds (MeTs), marine environment, sediments, pollution, degradation, methylation, transport]]></keywords_en><summary_hr><![CDATA[Tema predloženog projekta su organokositrovi spojevi kao zagađivala morskoga okoliša, a posebice tributilkositar (TBT), koji se koristi kao biocid u protuobraštajnim bojama, a za kojeg se smatra da je jedan od najštetnijih spojeva koje je čovjek ikada unio u morski okoliš. Unatoč zabranama, on je i dalje prisutan u morskom okolišu, posebice u sedimentima. Na temelju dosadašnjeg znanja o njegovom ponašanju i postojanosti, ne može se procijeniti do kada će predstavljati problem niti kako ga riješiti. S druge strane, metikositrovi (MeT) spojevi u morskom okolišu nisu isključivo antropogenog podrijetla, već mogu nastati i prirodnim putem, metilacijom anorganskog kositra. Iako se time mijenja biološka aktivnost i mobilnost kositra, uspješnost ovoga procesa i ponašanje MeT spojeva u morskom okolišu nisu razjašnjeni.Cilj ovoga interdisciplinarnog projekta je objasniti ponašanje, transformacije, prijenos i postojanost butilkositrovih (BuT) i MeT spojeva u morskom okolišu primjenom inovativnog i i sveobuhvatnog pristupa. Projekt će integrirati in situ istraživanje i primjenu naprednih analitičkih tehnika te biološko-molekularnih i sedimentoloških analiza kako bi se objasnili procesi kojima ovi spojevi podliježu u okolišu i čimbenici koji na te procese utječu. Objasnit će postojanost TBT-a u zagađenim sedimentima te utvrditi u kojoj mjeri oni mogu biti izvor zagađenja vodenoga stupca. Projektom će se također nastojati identificirati mikrobna zajednica koja ima aktivnu ulogu u razgradnji TBT-a u sedimentima, a stečeno znanje dat će značajan doprinos daljnjim istraživanjima s ciljem definiranja biotehnoloških postupaka bioremedijacije zagađenih sedimenata. Dodatni cilj projekta je utvrditi uspješnost procesa metilacije kositra u morskim sedimentima te utvrditi sudbinu i prijenos MeT spojeva u morskom okolišu.Predloženi projekt, osim što će odgovoriti na aktualna znanstvena pitanja, doprinijet će razvoju strategija za djelovanje u okviru programa zaštite morskog okoliša.]]></summary_hr><summary_en><![CDATA[The subject of the project is organotin compounds as pollutants in the marine environment, in particular tributyltin (TBT), which is used as a biocide in antifouling paints and is considered one of the most harmful compounds ever introduced into the marine environment. Despite bans, it is still present in the environment, particularly in sediments. Based on current knowledge, it is not possible to estimate how long it will be a problem or how to solve it. On the other hand, methyltin (MeT) compounds are not only of anthropogenic origin, but can also be formed naturally by methylation of inorganic tin. Although this alters the biological activity and mobility of tin, the effectiveness of methylation and behavior of MeT compounds are not yet known.The aim of this interdisciplinary project is to explain the behavior, transformation, and persistence of BuT and MeT compounds in the marine environment using an innovative and comprehensive approach. The project will integrate in situ research and advanced analytical techniques, as well as biological-molecular and sedimentological analyzes to explain the processes that these compounds undergo in the environment and the factors that influence these processes. The project will explain the persistence of TBT in polluted sediments and determine its possible role in the pollution of the water column. The project also aims to identify the microbial community that plays an active role in the degradation of TBT in sediments. The knowledge gained will make an important contribution to further research aimed at defining biotechnological processes for the bioremediation of polluted sediments. A further aim is to determine the efficiency of tin methylation and the fate and transfer of MeT compounds in the marine environment.In addition to answering current scientific questions, the proposed project will also contribute to the development of action strategies within the framework of programs for the protection of the marine environment.]]></summary_en></project><project>
<id>16971</id><title_hr><![CDATA[Multifunkcionalne površinski aktivne tvari s prijelaznim metalima: jednostavan put do nanomaterijala i niskodimenzionalnih magneta ]]></title_hr><title_en><![CDATA[Multifunctional metallosurfactants: a simple way to nanomaterials and low-dimensional magnets]]></title_en><user_id>339</user_id><user_firstLast_name>Darija Domazet Jurašin</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2024-05</proposal_call><code>IP-2024-05-3668</code><acronim><![CDATA[MSurf-n-SWIM]]></acronim><duration>09.12.2024 - 08.12.2027</duration><status>U tijeku</status><financ_value>199.525,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, Fizika, </scie_field_hr><scie_field_en>Chemistry, Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>224, 11197, 3035, 404, 868334, </team_members_id><team_members_names><![CDATA[Maja Dutour Sikirić, Mirta Herak, Katja Magdić Košiček, Vida Strasser, Ana Ivančić, ]]></team_members_names><keywords_hr><![CDATA[površinski aktivne tvari, nanočestice, kataliza, niskodimenzionalni magneti, prijelazni metali]]></keywords_hr><keywords_en><![CDATA[metallosurfactants, nanoparticles, catalysis, low-dimensional magnets, transition metals]]></keywords_en><summary_hr><![CDATA[Današnji ubrzani tehnološki razvoj sve više zahtjeva razvoj novih, isplativih, ekološki prihvatljivih i multifunkcionalnih materijala, a time i pronalaženje inovativnih riješenja u znanosti o materijalima. Površinski aktivne tvari (PAT) zbog svojih jedinstvenih fizikalno-kemijskih svojstava, kako u otopini tako i u krutom stanju, nude mnoge mogućnosti u tom području. PAT koje zadnje destljeće privlače veliku pažnju znanstvene zajedenice su PAT koje u svojoj strukturi sadrže prijelazne metale (M-PAT, engl. metallosurfactants) te time objedinjuju svojstva tradicionalnih, konvencionalnih PAT s onim metalnih, kompleksih spojeva.  Povezivanjem svojstava PAT i organometalne kemije nastaju jedinstveni materijali koji osim sposobnosti adsorpcije i asocijacije pokazuju magnetizam te katalitička i redoks svojstva. Zato je glavni cilj predloženog projekta dizajnirati i sintetizirati strukturno različite M-PAT (monomerne, dimerne i dvolančane) s odabranim prijelaznim metalima (Fe, Co, Ni, Cu) kako bi se dobili isplativiji, multifunkcionalni materijali poboljšanih fizikalno-kemijskih svojstava, u otopini i čvrstom stanju, pronalaženjem optimalnog odnosa između strukture i svojstava. S obzirom da PAT imaju ključnu ulogu u stabilizaciji nanostruktura, cilj je optimizirati jednostavnu, ekološki prihvatljiviju sintezu metalnih nanočestica (NPs) iz M-PAT kao prekursora metala. Sintetizirane M-PAT i metalne NPs će se dalje istražiti kao katalizatori za reakciju redukcije 4-nitrofenola u 4-aminofenol. Također, jedan od glavnih ciljeva predloženog projekta je istražiti M-PAT kao jeftine i lako dostupne materijale kao niskodimenzionale magnete velikog potencijala za primjenu u spinotronici i optoelektronici.]]></summary_hr><summary_en><![CDATA[In today&#39;s fast-tracked technological progress, the development of cost-effective, environmentally friendly, and multifunctional materials, and thus the pursuit of innovative solutions in materials science, has become of utmost importance. Due to their unique physico-chemical properties, both in solution and in the solid state, surfactants offer numerous possibilities in this development. The class of surfactants that has drawn much attention in the last decade is metallosurfactants. Metallosurfactants are a class of compounds that combine the properties of traditional, conventional surfactants with those of metal-containing complexes by incorporating a transition and/or inner-transition metal as an integral structural element. The incorporation of metal in the surfactant&#39;s molecular structures offers several new properties, such as variable oxidation states, magnetism, and pH sensitivity. Therefore, the main objectives of the proposed project are to design and synthesize structurally different metallosurfactants (monomeric, dimeric, and double-chain) with selected transition metals (Fe, Co, Ni, Cu) in order to obtain simple-to-produce, cost-effective, multifunctional metallosurfactants with improved self-assembly and solution properties by establishing an optimal structure-property relationship. Considering that surfactant ions play a key role in the stabilization of nanostructures, the goal is to optimize the simple, environmentally friendly synthesis of metallic nanoparticles (NPs) from synthesized metallosurfactants as metal precursors. Synthesized metallosurfactants and metallic NPs will be further tested for catalysing the reduction reaction of 4-nitrophenol to 4-aminophenol. But most importantly, proposed project aims to explore metallosurfactants as a simple approach for the design and synthesis of novel low-dimensional magnetic systems of great potential for future spintronic and optoelectronic devices. ]]></summary_en></project><project>
<id>16974</id><title_hr><![CDATA[Derivati cijaninskih boja – nove probe za nukleinske kiseline i bioprobe sa antitumorskim i antibakterijskim djelovanjem]]></title_hr><title_en><![CDATA[Cyanine derived dyes – new nucleic acid probes and bioprobes with antitumor and antibacterial activity]]></title_en><user_id>1214</user_id><user_firstLast_name>Marijana Radić Stojković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2024-05</proposal_call><code>IP-2024-05-7701</code><acronim><![CDATA[CyaBioProbe]]></acronim><duration>09.12.2024 - 08.12.2027</duration><status>U tijeku</status><financ_value>199.640,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, Biologija, </scie_field_hr><scie_field_en>Chemistry, Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>2953, 2522, 867802, 3527, 3856, 873011, 865429, </team_members_id><team_members_names><![CDATA[Lidija-Marija Tumir, Renata Kobetić, Atanas Kurutos, Ranko Stojković, Nataša Šijaković Vujičić, Nina Vukadinović, Marta Jurković, ]]></team_members_names><keywords_hr><![CDATA[organska sinteza, cijaninske probe, DNA i RNA prepoznavanje, primjena hidrogelova, teranostički učinak, istraživanja in vitro i in vivo]]></keywords_hr><keywords_en><![CDATA[organic synthesis, cyanine probes, DNA and RNA recognition, application of hydrogels, theranostic effect, in vitro and in vivo research ]]></keywords_en><summary_hr><![CDATA[Primjena molekularnih proba za vizualizaciju biomolekula i bioloških uzoraka dobiva na važnosti u biokemijskim i biomedicinskim istraživanjima. Osim detekcije biološke mete, neke probe pokazuju antitumorske i antibakterijske učinke. Ovo svojstvo je osobito značajno s obzirom na porast otpornosti na antibiotike i sve veću učestalost raznih vrsta raka.Među brojnim nekovalentnim probama malih molekula, cijaninske boje poznate su kao izvrsne probe za nukleinske kiseline i sredstva i za in vitro i in vivo vizualizaciju i terapijsku upotrebu. Monometinske i polimetinske cijaninske boje su odlične molekularne probe zbog svojih značajki, kao što su visoki ekstinkcijski koeficijenti, dublje prodiranje u tkivo, smanjena pozadinska autofluorescencija i osjetljivost na njihovu molekularnu okolinu.Očekuje se da će projekt rezultirati novim bioprobama s monometinskim i polimetinskim (tri-, penta- i uglavnom heptametinskim) cijaninskim strukturama s mogućnošću prepoznavanja meta, njihove vizualizacije i/ili biološkog učinka. To će se postići ispunjavanjem sljedećih ciljeva: sinteza novih spojeva, istraživanje njihovih interakcija s biomakromolekulama te proučavanje biološkog učinka in vitro i in vivo. Također će se istraživati nano-hidrogelovi kao sustavi isporuke za terapeutsku primjenu.Projekt će pridonijeti obogaćivanju u području istraživanja i sintetske knjižnice našeg laboratorija novom generacijom proba na bazi cijanina s potencijalom vizualizacije i selektivnog prepoznavanja bioloških meta i terapeutika. Omogućit će objavljivanje rezultata istraživanja u kvalitetnim časopisima, te ojačati međuinstitucijsku suradnju. Novi derivati cijanina mogu se primijeniti u molekularnoj medicini za detekciju specifičnih molekula/biomolekula, istraživanje i razvoj lijekova te praćenje bakterija otpornih na antibiotike u uzorcima iz okoliša, prehrambenim proizvodima i stočnoj hrani.]]></summary_hr><summary_en><![CDATA[The application of molecular probes for visualizing biomolecules and biological samples is gaining importance in biochemical and biomedical research. Besides biological target detection, some probes display antitumor and antibacterial effects. This feature is particularly significant given the rise of antibiotic resistance and the escalating incidence of various cancer types.Among numerous non-covalent small molecule probes, cyanine dyes are known as excellent nucleic acid probes and agents for in vitro and in vivo visualization and therapeutic use. Monomethine and polymethine cyanine dyes make excellent molecular probes due to their distinctive features, such as high extinction coefficients, deeper tissue penetration, reduced background autofluorescence and sensitivity to their molecular environment.The project is expected to result in new bioprobes with monomethine and polymethine (tri-, penta-, and mainly heptamethine) cyanine structures with the possibility of target recognition, their visualization, and/or biological effect. This will be achieved by fulfilling the following goals: synthesis of new compounds, investigating their interactions with biomacromolecules, and studying the biological effect in vitro and in vivo. Nanosized hydrogels as delivery systems for therapeutic applications will also be explored.The project will contribute to the enrichment of field research and the synthetic library of our laboratory with a new generation of cyanine-based probes with the potential for visualization and selective recognition of biological targets and therapeutics. It will enable the publication of research results in quality journals, and strengthen inter-institutional collaboration. New cyanine derivatives can be applied in molecular medicine for the detection of specific molecules/biomolecules, drug research and development and the monitoring of antibiotic-resistant bacteria in environmental samples, food products and animal feed.]]></summary_en></project><project>
<id>16980</id><title_hr><![CDATA[Metamorfna bespilotna letjelica visokih preformansi]]></title_hr><title_en><![CDATA[A High Performance Metamorphic Unmanned Aerial Vehicle]]></title_en><user_id>5244</user_id><user_firstLast_name>Stjepan Bogdan</user_firstLast_name><svouser_id>868356</svouser_id><svouser_firstLast_name>Kovac Mirko</svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2024-05</proposal_call><code>IP-2024-05-9849</code><acronim><![CDATA[MetaMorpher]]></acronim><duration>20.12.2024 - 19.12.2027</duration><status>U tijeku</status><financ_value>193.080,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Interdisciplinarne tehničke znanosti, Elektrotehnika, Računarstvo, Temeljne tehničke znanosti, </scie_field_hr><scie_field_en>Interdisciplinary technological sciences, Electrical engineering, Computer sciences, Basic engineering sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>5058, 21420, 28644, 872911, </team_members_id><team_members_names><![CDATA[Frano Petric, Matko Orsag, Ana Milas, Anja Bosak, ]]></team_members_names><keywords_hr><![CDATA[bespilotne letjelice, meka robotika, inteligentni materijali, osmatranje okoliša, adaptivno upravljanje]]></keywords_hr><keywords_en><![CDATA[unmanned aerial vehicles, soft robotics, material intelligence, environmental sensing, adaptive control]]></keywords_en><summary_hr><![CDATA[Projektiranje nelinearne, energetski učinkovite, bespilotne letjelice (UAV), kao i upravljanje njezinim letom i dalje predstavlja istraživačk izazov. Ovaj projektni prijedlog istražit će dizajn i upravljanje bespilotnom letjelicom koja se temelji na metamorfozi između dva različita principa letenja - rotirajućih krila (rotatinf wings) i jedrenja (gliding). Aerodinamičke, energetske, senzorske, strukturalne i komunikacijske sposobnosti UAV-a bit će razmotrene kako bi cjelokupni sustav ispunio svoju ulogu. Sa znanstvene točke gledišta, projekt MetaMorpher iznimno je izazovan jer je ovo prvi put, koliko znamo, da se istražuju metamorfoze tijekom leta, od rotirajućih krila do jedrilice. Jasno je da takva promjena u strukturi bespilotne letjelice, prije svega, zahtijeva duboko razumijevanje dinamike leta i dizajna profila krila, tako da se koriste odgovarajući materijali (osobito u kontekstu novih razgradivih tvari) za strukturu, posebno krila, koja mogu podnijeti nagle promjene u otporu zraka i prilagoditi se različitim smjerovima i brzinama strujanja zraka. S tim u vezi znanje i iskustvo LSR EMPA tima u dizajnu UAV-a je ključno. Uspješan ishod u dizajnu konstrukcije imat će značajnu znanstvenu važnost za sve buduće pokušaje ka energetski učinkovitim letovima. Drugi izazov, koji je u fokusu tima LARICS UNIZG-FER, odnosi se na upravljanje bespilotnim letjelicama s promjenjivom strukturom. Postojeći algoritmi za upravljanje multirotorskim letjelicama i letjelicama s fiksnim krilima mogu se izravno implementirati samo tijekom dvije glavne faze leta MetaMorpher letjelice - polijetanja/slijetanja i jedrenja, dok prijelaz tijekom slobodnog pada zahtijeva dizajn namjenskog mehanizma upravljanja, kako bi UAV ostao stabilan i postigao unaprijed zadanu misiju.]]></summary_hr><summary_en><![CDATA[The design and control of highly nonlinear, energy efficient, Unmanned Aerial Vehicle (UAV) remains a challenging research field. This research proposal will explore the design and control of an aerial system based on metamorphosis between two different principles of flying - rotating wings and gliding. The aerodynamic, energetic, sensorial, materials and communicative capabilities of the UAV will be appropriately considered so that the overall system fulfills its purpose. From the scientific point of view, the MetaMorpher project is extremely challenging as this is the first time, to the best of our knowledge, that in-flight metamorphoses from rotating wings to gliding has been investigated. Clearly, such change in the UAV structure, first of all, requires deep understanding of flight dynamics and airfoil design so that appropriate materials (especially in context of novel degradable substances) are used for the structure, particularly wings, that can sustain abrupt change in drag and accommodate for various directions and speeds of the air. With that respect the know-how and the experience of the LSR EMPA team in UAV design is essential. Successful outcome of the structural design will have significant scientific importance for all future attempts towards energy efficient flights. Second challenge, that is in focus of LARICS UNIZG-FER team, is related to the control of UAV with changeable structure. Existing algorithms for rotorcraft and fixed wing control can be directly implemented only during two major phases of MetaMorpher flight - takeoff/landing and gliding, while transition during the freefall requires design of dedicated control mechanism, so that UAV stays stable and achieve predetermined mission.]]></summary_en></project><project>
<id>16986</id><title_hr><![CDATA[Adresiranje onečišćenja bakrom u južnoj Europi razvojem cjelostaničnih biosenzora s robusnijom staničnom stijenkom]]></title_hr><title_en><![CDATA[Addressing copper pollution in South Europe by robustifying whole-cell copper biosensors through cell wall engineering]]></title_en><user_id>4450</user_id><user_firstLast_name>Bojan Žunar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2024-05</proposal_call><code>IP-2024-05-5224</code><acronim><![CDATA[robustiCo]]></acronim><duration>09.12.2024 - 08.12.2027</duration><status>U tijeku</status><financ_value>200.000,00 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Biotehnologija, </scie_field_hr><scie_field_en>Biotechnology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Food Technology and Biotechnology]]></institution_en><team_members_id>3258, 4377, 29158, 25073, 868368, </team_members_id><team_members_names><![CDATA[Renata Teparić, Igor Stuparevic, Damir Baranasic, Ana Novačić, Antonia Paić, ]]></team_members_names><keywords_hr><![CDATA[Saccharomyces cerevisiae, cjelostanični biosenzor, stanična stijenka, izlaganje proteina na staničnu površinu, platforma za sintetsku biologiju]]></keywords_hr><keywords_en><![CDATA[Saccharomyces cerevisiae, whole-cell biosensors, yeast cell wall, surface display, synthetic biology chassis]]></keywords_en><summary_hr><![CDATA[Suvremena industrija i moderne poljoprivredne tehnike onečišćuju tlo bakrom koji, ulazeći u prehrambene lance, uzrokuje ozbiljne zdravstvene probleme. Povišene koncentracije bakra posebno su zabrinjavajuće u južnoj Europi, poznatoj po organskoj poljoprivredi, proizvodnji vina i maslinovog ulja te rudarenju metala. S druge strane, kvantifikacija biodostupnog bakra i dalje je izazovna, što otežava zaštitu javnog zdravlja. Naša istraživačka grupa ranije je razvila omjerni biosenzor za biodostupni bakar koji se ističe po svojoj izvrsnoj granici detekcije (10 nM), linearnom rasponu i specifičnosti, ali koji teško kvantificira biodostupni bakar u uzorcima tla zagađenima teškim metalima i/ili ugljikovodicima. Takva smanjena djelotvornost biosenzora u ne-laboratorijskim uvjetima čest je problem, budući da su ti alati dizajnirani unutar standardnih laboratorijskih sojeva koji su jednostavni za korištenje, ali ne i robusni.Naša istraživačka grupa ima bogato iskustvo u radu s kvascima iz roda Saccharomyces, razvoju biosenzora, prikazivanju proteina na staničnoj površini i strojnom učenju. Stoga će naša istraživačka grupa tijekom provedbe projekta robustiCo identificirati i razvijati sojeve iz roda Saccharomyces koje njihova stanična stijenka čini otpornijima na česte zagađivače tla i druge okolišne stresore. Istraživačka grupa će zatim razvijeni robustificirani soj: i) prilagoditi za mjerenje bakra u ne-laboratorijskim uvjetima te ga ii) koristiti za izlaganje lakaza na staničnoj stijenci, tj. multibakrenih oksidaza koje mogu razgraditi azo boje, zagađivače često prisutne u otpadnim vodama tekstilne industrije. Uz ova dva glavna cilja, projekt robustiCo ujedno će: iii) mapirati raznolikost stanične stijenke unutar roda Saccharomyces, iv) odrediti pan-proteom stanične stijenke unutar roda Saccharomyces, v) razviti bolje sojeve za prikaz proteina na staničnoj površini i vi) identificirati mehanizme koji staničnu stijenku kvasca čine robusnijom.]]></summary_hr><summary_en><![CDATA[Modern technology and copper-reliant agriculture pollute the soil with excess copper, which then enters the food chains, causing severe health problems. Heightened copper concentrations are especially prevalent in South Europe, known for organic farming and famous for its wine, olive oil, and metal production. However, quantifying bioavailable copper, i.e., copper that can enter cells, remains challenging, thus hindering legal oversight and undermining public health. We previously developed a ratiometric biosensor for bioavailable copper that has a superior detection limit (10 nM), linear range, and specificity but which struggled to measure copper in samples with common soil pollutants, e.g., heavy metals and/or hydrocarbons. Such real-world underperformance of synthetic biology tools is a widespread issue, as these tools are designed around standard laboratory chassis, which are used because they are easy to manipulate, not because they are robust.In the robustiCo project, we will draw on our extensive experience in manipulating Saccharomyces yeasts, biosensor development, surface display, cell wall engineering, and machine learning to identify Saccharomyces chassis whose cell wall protects it better from common real-world pollutants. By focusing on the cell wall as the cell’s primary protective structure, we will develop a chassis that is resilient to various environmental stressors. Once we develop such a robustified chassis, we will i) retool it into a real-world-compatible copper biosensor and ii) use it for the surface display of laccases, i.e., multicopper oxidases that can degrade azo dyes, common pollutants in effluents from the textile industry. In addition to these two main objectives, throughout the project, we will: iii) map cell wall diversity of the Saccharomyces clades, iv) catalogue cell wall pan-proteome, v) engineer better surface display chassis, and vi) identify the mechanisms underlying yeast cell wall robustification.]]></summary_en></project><project>
<id>16987</id><title_hr><![CDATA[Genski, laboratorijski, histološki i klinički prediktori ishoda bolesnika s IgA vaskulitisom]]></title_hr><title_en><![CDATA[Genetic, laboratory, histological and clinical predictors of outcome in patients with IgA vasculitis]]></title_en><user_id>26821</user_id><user_firstLast_name>Marija Jelušić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2024-05</proposal_call><code>IP-2024-05-6848</code><acronim><![CDATA[IGAPREDICTORS]]></acronim><duration>04.12.2024 - 03.12.2027</duration><status>U tijeku</status><financ_value>200.000,00 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Kliničke medicinske znanosti, Javno zdravstvo i zdravstvena zaštita, </scie_field_hr><scie_field_en>Clinical sciences, Public health and health services, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>20465, 4155, 2695, 19435, 26368, 22799, 27191, 27037, 868419, 868499, 868442, 868549, 868457, 4711, 872966, </team_members_id><team_members_names><![CDATA[Alenka Gagro, Marijana Ćorić, Gordana Laškarin, Ana Kozmar, Mario Šestan, Nada Tomić Sremec, Nastasia Kifer, Saša Sršen, Daniel Turudić, Rae S.M. Yeung, Zrinka Bukvić Mokos, Marijan Frković, Kristina Vrljičak, Stela Bulimbašić, Hana Musil, ]]></team_members_names><keywords_hr><![CDATA[ IgA vaskulitis, glomerulonefritis, biomarkeri, biopsija, histologija, djeca, ekspresija gena, alarmini]]></keywords_hr><keywords_en><![CDATA[IgA Vasculitis, Glomerulonephritis, Biomarkers, Biopsy, Histology, Children, Gene Expression, Alarmins]]></keywords_en><summary_hr><![CDATA[Ovaj je projekt nastavak prethodnog projekta HRZZ-a, IP-2019-04-8822, u čijem je fokusu i dalje najčešći vaskulitis u dječjoj dobi - IgA vaskulitis (IgAV) ili Henoch-Schönleinova purpura. U sklopu nacionalnog multicentričnog istraživanja u tri tercijarna pedijatrijska reumatološka i nefrološka centara nastavljamo istraživati kompleksnu patogenezu bolesti i njezine ishode. Cilj nam je prikazati kratkoročne i dugoročne ishode određenih podskupina bolesnika s IgAV-om, kao što su oni s perzistentnom izoliranom mikro ili makrohematurijom, onih s težim kožnim promjenama ili gastrointestinalnim manifestacijama, onih u kojih je IgAV započeo u kasnijoj dobi, kako bismo mogli definirati osobitosti u praćenju navednih podskupina bolesnika budući da još uvijek nisu poznati dugoročni ishodi takvih bolesnika te stoga nema preporuka kako ih pratiti. Nadalje, cilj nam je Istražiti mogućnost korištenja kalprotektina (S100A8/A9), proteina visoke pokretljivosti iz skupine 1 (HMGB1), IgA protutijela na ßII-spektrin (anti-SPTBN1 IgA), sindekana i glipikana kao biomarkera razvoja teže kliničke slike bolesti, nefritisa (IgAVN), aktivnosti upale i predskazatelja trajanja bubrežne bolesti. Ispitat ćemo ekspresiju gena sustavom NanoString u uzorcima kože i bubrega u djece s IgAV-om/IgAVN-om koja nisu liječena imunosupresivnom terapijom primjenom imunološkog panela gena te ekspresiju gena reguliranih interferonom tipa I u perifernoj krvi bolesnika kako bismo utvrdili mogu li nam dobivena saznanja pomoći u otkrivanju djece s rizikom za komplikacije IgAV-a. Očekujemo da će nam projekt pomoći u pravovremenom prepoznavanje djece s rizicima za komplikacije i planiranju personaliziranog pristupa liječenju. Nadamo se da će to pridonijeti prepoznavanju nezadovoljenih potreba bolesnika, a ujedno i osnažiti i konsolidirati međunarodnu istraživačku mrežu iz područja IgAV/IgAVN. ]]></summary_hr><summary_en><![CDATA[This project proposal is a continuation of the prior endeavor HRZZ project, IP-2019-04-8822, and remains focused on the most prevalent childhood vasculitis - IgA vasculitis (IgAV) or Henoch-Schönlein purpura. Spanning three tertiary pediatric rheumatology and nephrology centers nationally, our research perseveres in delving into the intricate pathogenesis of the disease and its outcomes. One of our primary objectives is to elucidate both short-term and long-term outcomes for specific subgroups of IgAV patients. These include those with persistent isolated micro- or macrohematuria, more severe skin changes, or gastrointestinal manifestations, along with individuals where IgAV onset occurred later in life. The goal is to define follow-up protocols for these subgroups since their long-term prognoses remain unknown, leading to a lack of established follow-up recommendations. Furthermore, we aim to explore the potential utility of calprotectin (S100A8/A9), high mobility group protein B1 (HMGB1), IgA antibodies to ßII-spectrin (anti-SPTBN1 IgA), syndecan, and glypican as biomarkers for predicting disease severity, nephritis (IgAVN), inflammatory activity, and the duration of kidney disease. Our investigation will involve analyzing gene expression using the NanoString system in skin and kidney samples from untreated children with IgAV/IgAVN, utilizing an immune gene panel. Additionally, we will assess the expression of genes regulated by type I interferon in patients&#39; peripheral blood to ascertain whether this knowledge aids in identifying at-risk children for IgAV complications. Anticipated outcomes of this project include the timely identification of high-risk children and the development of personalized treatment strategies. We aspire for our efforts to shed light on unmet patient needs while fortifying the international research network dedicated to IgAV/IgAVN.]]></summary_en></project><project>
<id>16988</id><title_hr><![CDATA[Koordinirani sustavi i tržišta vodika i električne energije]]></title_hr><title_en><![CDATA[Coordinated Hydrogen and Electricity SyStems and markets]]></title_en><user_id>7162</user_id><user_firstLast_name>Hrvoje Pandžić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2024-05</proposal_call><code>IP-2024-05-6299</code><acronim><![CDATA[CHESS]]></acronim><duration>16.12.2024 - 15.12.2027</duration><status>U tijeku</status><financ_value>198.842,50 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>12950, 6804, 868490, 3538, 868415, 868406, 20291, 25844, 865405, 868370, 856080, 20181, 26067, 872912, 18920, </team_members_id><team_members_names><![CDATA[Ivan Andročec, Ivica Pavić, Kenneth Bruninx, Renata Rubeša, Matija Kostelac, Ivana Hrgović, Hrvoje Bašić, Karlo Šepetanc, Petra Drašković, Luka Budin, Nikolina Čović, Vedran Bobanac, Sara Raos, Ante Galić, Željko Penga, ]]></team_members_names><keywords_hr><![CDATA[spremnici energije, baterijski spremnici energije, vodik, elektrolizator, gorivni članak, tokovi snaga, energetska tržišta]]></keywords_hr><keywords_en><![CDATA[energy storage, battery energy storage, hydrogen, electrolyzer, fuel cell, power flow, energy markets]]></keywords_en><summary_hr><![CDATA[Golemi rast varijabilnih obnovljivih izvora energije (vjetroelektrana i solarnih elektrana) zahtijeva integraciju spremnika energije u elektroenergetski sustav. Projekt je usmjeren na pružanje fleksibilnosti korištenjem dvije tehnologije pohrane energije, baterijskih sustava i vodika. Prvi cilj projekta je razviti točne modele baterijskih spremnika energije temeljenih na laboratorijskim mjerenjima koja uzimaju u obzir specifičnosti litij-ionske tehnologije poput varijabilne učinkovitosti i mogućnosti punjenja te degradacije. Drugi cilj je razviti točne modele elektrolizatora i gorivnih članaka. Modeli će biti također razvijeni na temelju laboratorijskih mjerenja i procedura i uzimat će u obzir promjenjivu učinkovitost i učinke čestih promjena radne točke, primjerice prilikom pružanja brzih frekvencijskih usluga operatoru sustava, na degradaciju. Razvijeni modeli će se potom koristiti u trećem cilju u svrhu formuliranja optimalnog pogonskog modela fleksibilnog postrojenja (koji se sastoji od obnovljivih izvora energije i spremnika energije) koji sudjeluje u tržištima električne energije i vodika uvjetima nesigurnosti. Pogonski model fleksibilnog postrojenja nadogradit će se i formulirati optimalni investicijski model za takvo postrojenje koje sudjeluje na više energetskih tržišta. Posljednji cilj projekta je razviti brze modele optimalnih tokova snaga i vodika. Ti modeli će se koristiti za simulaciju čišćenja tržišta električne energije i vodika u modelu fleksibilnog postrojenja čiji je kapacitet dovoljno velik da ima utjecaj na tržišne cijene električne energije i vodika. Rezultirajući dvorazinski modeli bit će učinkovito riješeni korištenjem neuronskih mreža. Rezultati projekta imat će važan utjecaj na upravljačke algoritme baterija, elektrolizatora i gorivnih članaka te će povećati tržišni profit kroz pružanje različitih usluga. Laboratorijska mjerenja su ključna za potvrđivanje razvijenih algoritama i osiguranje fizičke izvedivosti dobivenih rasporeda. ]]></summary_hr><summary_en><![CDATA[The high rate of growth of variable renewable sources, i.e. solar and wind, calls for integration of energy storage in power systems. This project focuses on flexibility provision of two storage technologies, battery storage and hydrogen. The first project objective is to develop accurate models for battery storage based on laboratory measurements, taking into consideration the specifics of the lithium-ion battery technology such as variable efficiency, variable charging rates, and degradation.  The second objective is to develop accurate models of electrolyzers and fuel cells. Also based on laboratory procedures and measurement, considering the variable efficiency and effects of operating point changes, e.g. when providing fast frequency response to the system operator, on degradation. The developed models will be then used in the third objective to formulate the optimal flexible facility (consisting of renewable sources and energy storage) bidding model under uncertainty in the power and hydrogen markets. The flexible facility operational models will be expanded to derive the optimal investment model for a flexible facility taking part in various markets. The final objective will be to develop fast and efficient optimal power flow and hydrogen flow models. These models will be used to simulate electricity and hydrogen market clearing for price-making flexible facilities whose bids affect market prices. The resulting bilevel models will be effectively solved using the neural network approach. The project results will have a strong impact on the battery, electrolyzer and fuel cell control algorithms, improving the market profit from different revenue streams. The laboratory measurements are crucial for validating the developed algorithms and ensure feasibility of the obtained schedules in reality. ]]></summary_en></project><project>
<id>16994</id><title_hr><![CDATA[Semileptonske probe fizike b-kvarka na budućim eksperimentima okusa]]></title_hr><title_en><![CDATA[Semileptonic probes of b-quark physics at future flavour experiments]]></title_en><user_id>866160</user_id><user_firstLast_name>Ivan Nišandžić</user_firstLast_name><svouser_id>866230</svouser_id><svouser_firstLast_name>Nejc Košnik</svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2024-05</proposal_call><code>IP-2024-05-6159</code><acronim><![CDATA[SEMPRE]]></acronim><duration>11.12.2024 - 10.12.2027</duration><status>U tijeku</status><financ_value>131.180,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>2665, 868394, 868410, 868402, </team_members_id><team_members_names><![CDATA[Blaženka Melić, Aleks Smolkovič, Lovre Pavičić, Luka Leskovec, ]]></team_members_names><keywords_hr><![CDATA[semileptonski raspadi B mezona, efektivna teorija polja, elektromagnetne korekcije, raspadne sirine, hadronski matricni elementi]]></keywords_hr><keywords_en><![CDATA[semileptonic B meson decays, effective field theory, electromagnetic corrections, decay widths, hadronic matrix elements]]></keywords_en><summary_hr><![CDATA[U ovom projektu namjeravamo produbiti naše razumijevanje semileptonskih procesa unutar standardnog modela (SM) i njegovih proširenja (BSM). Semileptonski raspadi hadrona koji sadrže b-kvark služe kao savršen testni poligon budući da su povezani s najtežom poznatom česticom - top kvarkom - za koju se očekuje da bi mogla biti pod najvećim utjecajem BSM fizike. Nadalje, takvi raspadi omogućuju testiranje univerzalnosti okusa leptona (LFU), značajnog predviđanje standardnog modela. Nedavne eksperimentalne i teorijske aktivnosti na području LFU potaknute su naznakama odstupanja između predviđanja SM-a i eksperimentalnih opažanja u LFU-omjerima R(D) i R(D*).  Pri proučavanju semileptonskog raspada B -> D l nu cilj nam je uspostaviti robustne veze između teorijskih predviđanja i eksperimentalnih promatranja. Konkretno, naš cilj je pružiti poboljšanu evaluaciju elektromagnetskih efekata u LFU omjeru R(D).  Dodatno, istražit ćemo učinke CP-neparnih konstanti vezanja u semileptonskim procesima na Velikom hadronskom sudaraču (LHC). U ovom dijelu predložit ćemo CP-neparne diferencijalne opservable u semileptonskom procesu pp -> b c tau nu i povezanim procesima. Te opservable dizajnirane su da budu osjetljivi isključivo na scenarije BSM fizike u kojima je CP simetrija narušena a koji mogu objasniti anomalije R(D) i R(D*). Nadalje, naše istraživanje proširuje se na inkluzivne raspade teških hadrona, s fokusom na b-barione unutar okvira razvoja teškog kvarka. Cilj nam je detaljno proučiti odgovarajuće matrične elemente efektivnih operatora koristeći se nedavnim evaluacijama u kvantnoj kromodinamiki na mreži i pravilima sume na malim brzinama, čime ćemo poboljšati naše razumijevanje neperturbativnih efekata te odgovarajućih implikacija za eksperimentalna mjerenja.Očekivani rezultati ovog projekta unaprijedit će naše teorijske uvide i služiti kao vodič za eksperimente fizike okusa na niskim energijama, kao i za eksperimente visokog pT-a na LHC-u.]]></summary_hr><summary_en><![CDATA[In this project we aim to deepen our understanding of semileptonic processes within the Standard Model (SM) and its extensions (BSM). Semileptonic decays of hadrons containing a b-quark serve as an ideal testing ground, as they are intricately linked to the heaviest known particle - the top quark - which is anticipated to be most affected by BSM physics. Furthermore, such decays enable the testing of lepton flavour universality (LFU), a fundamental prediction of the Standard Model. Recent experimental and theoretical activities in LFU have been prompted by hints of discrepancies between SM predictions and observations in LFU ratios such as R(D) and R(D*).In our study of the semileptonic decay B -> D l nu, we aim to establish robust links between theoretical (B)SM predictions and experimental observations. Specifically, our goal is to provide a refined evaluation of electromagnetic effects in the LFU-probing observable ratio R(D).Additionally, we will explore the effects of CP-violating couplings in semileptonic processes at the Large Hadron Collider (LHC). In this part we will propose CP-odd differential observables in semileptonic process pp -> b c tau nu and related processes. These observables are designed to be sensitive to exclusively to CP-violating scenarios of BSM that address the R(D) and R(D*) anomalies.Furthermore, our research extends to inclusive decays of heavy hadrons, focusing on b-baryons within the heavy quark expansion (HQE) framework. We aim to scrutinise forward matrix elements of effective operators by leveraging recent lattice QCD determinations and small velocity sum rules, thereby enhancing our understanding of non-perturbative effects and corresponding implications for experimental measurements.The anticipated outcomes of this project will improve our theoretical insights and guide flavour physics experiments at low energies as well as at high-pT experiments at the LHC.]]></summary_en></project><project>
<id>17005</id><title_hr><![CDATA[Utjecaj poduzeća na nejednakosti na tržištu rada: Uvidi iz Hrvatske i Slovenije tijekom posljednjih pedeset godina]]></title_hr><title_en><![CDATA[The role of firms in labor market inequalities: Evidence from Croatia and Slovenia over the past fifty years]]></title_en><user_id>868388</user_id><user_firstLast_name>Filip Novokmet</user_firstLast_name><svouser_id>868621</svouser_id><svouser_firstLast_name>Barbara Kalar</svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2024-05</proposal_call><code>IP-2024-05-5629</code><acronim><![CDATA[FIRMLAB]]></acronim><duration>20.12.2024 - 19.12.2027</duration><status>U tijeku</status><financ_value>86.620,00 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, </scie_field_hr><scie_field_en>Economy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Ekonomski fakultet u Zagrebu]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Economics and Business]]></institution_en><team_members_id>868511, 13295, 868541, </team_members_id><team_members_names><![CDATA[Ria Ivandic, Velibor Mačkić, Filip Novinc, ]]></team_members_names><keywords_hr><![CDATA[povezani podaci poslodavac-zaposlenik, nejednakost plaća, monopson, produktivnost rada, Hrvatska i Slovenija]]></keywords_hr><keywords_en><![CDATA[linked employer-employee data, wage inequality, monopsony,  labor productivity, Croatia and Slovenia]]></keywords_en><summary_hr><![CDATA[Nejednakosti plaća su snažno porasle od 1980-ih. Porast je posebno izražen u bivšim socijalističkim zemljama, uključujući Hrvatsku i Sloveniju. Međutim, doprinos poduzeća rastu nejednakosti nije sustavno istražen. Ovaj projekt ima za cilj analizirati ulogu poduzeća u dinamici nejednakosti plaća u Hrvatskoj i Sloveniji od 1970. do danas. U tu svrhu izradit ćemo prve longitudinalne baze podataka poslodavac-zaposlenik za Hrvatsku i Sloveniju, koje pokrivaju cjelokupnu populaciju radnika i poduzeća tijekom razdoblja istraživanja (povezane baze podataka poslodavac-zaposlenik). Na temelju toga procijenit ćemo nove konzistentne serije nacionalne nejednakosti plaća u dvjema zemljama u posljednjih pedeset godina i raščlaniti trendove nejednakosti plaća na komponente unutar i između poduzeća. Korištenjem novih jedinstvenih baza podataka i naprednih ekonometrijskih metoda, daljnja dekompozicija  komponente nejednakosti između poduzeća omogućit će identifikaciju premija na plaće specifičnih za poduzeće. Ovi su rezultati od iznimne važnosti za ekonomiste i nositelje politike budući da bi ukazivali na stupanj monopsonske moći poduzeća u određivanju plaća na tržištu rada, te će predstavljati ključan input u razmatranjima kako modelirati tržište rada i pri osmišljavanju odgovarajućih ekonomskih politika. Ovaj će projekt stoga pružiti jedinstven resurs istraživačima i ponuditi smjernice za rješavanje rastućih nejednakosti na tržištu rada.]]></summary_hr><summary_en><![CDATA[Wage inequality has strongly increased worldwide since the 1980s. An increase has been especially pronounced in former socialist countries, including Croatia and Slovenia. However, the contribution of firms to the evolution of wage inequality has not been systematically investigated. This project aims to analyze the role of firms in determining the wage inequality dynamics in Croatia and Slovenia from 1970 until today. For this purpose, we will construct the first longitudinal employer-employee datasets for Croatia and Slovenia, covering the entire population of workers and firms over the study period (linked employer-employee dataset). Based on it, we will estimate the new consistent series of national wage inequality in the two countries over the last fifty years, and decompose wage inequality trends into within- and between-firm components. Using new unique datasets and advanced econometric techniques, a further decomposition of between-firm inequality will permit the identification of firm-specific wage premiums. These results are of utmost importance for both economists and policymakers since they would indicate the degree of wage-setting (monopsony) power of employers in the labor market over time and over sectors, and hence present a critical input on how to model labor markets and formulate appropriate policies.  This project will thus provide a unique research resource and serve as a policy guide to address rising inequalities in the labor market.]]></summary_en></project><project>
<id>17014</id><title_hr><![CDATA[Energetsko planiranje sljedeće faze tranzicije uz pomoć umjetne inteligencije]]></title_hr><title_en><![CDATA[AI-Aided Energy Planning for the Next Phase of Transition]]></title_en><user_id>13012</user_id><user_firstLast_name>Neven Duić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2024-05</proposal_call><code>IP-2024-05-4547</code><acronim><![CDATA[AI-NPT]]></acronim><duration>10.12.2024 - 09.12.2027</duration><status>U tijeku</status><financ_value>167.090,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, </scie_field_hr><scie_field_en>Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>867614, 865227, 27136, 868431, 868518, 868528, 27141, 868489, 862777, 20485, </team_members_id><team_members_names><![CDATA[Saqib Ali, Luka Herc, Antun Pfeifer, Doris Beljan, Henning Meschede, Marko Starčević, Iva Ridjan Skov, Daniele Groppi, Felipe Feijoo, Henrik Lund, ]]></team_members_names><keywords_hr><![CDATA[Energetsko planiranje, optimizacija, obnovljivi izvori energije, energetski vektori, pomičan horizont, neuralne mreže]]></keywords_hr><keywords_en><![CDATA[Energy planning, optimization, renewable energy systems, energy vectors, moving horizon, neural networks, ]]></keywords_en><summary_hr><![CDATA[Ovaj projekt je usredotočen na izazove u modeliranju energetske tranzicije s posebnim naglaskom na elektrifikaciju i dekarbonizaciju sektora koje je teško dekarbonizirati, kao što su industrija i transport. Predložena metoda predstavlja odmak od aktualnog pristupa sa savršenim predviđanjem prema pristupu koji koristi pomični horizont. Primjenom takve metode se omogućuje 1) dinamičan odgovor na različite buduće uvjete i okolnosti u kojima se sustav nalazi i 2) smanjenje računalnih zahtjeva trenutnih modela, koji su do sad predstavljali ograničenje. Predloženi pristup nudi veću fleksibilnost u upravljanju brzim promjenama dostupnosti resursa i neočekivanim događajima, kao što su ekstremni vremenski uvjeti. Tako se model prilagođava ograničenjima dostupne računalne opreme. Predviđeni skupovi podataka generiraju se korištenjem tehnike dubokog učenja, konkretno neuronskih mreža treniranih na povijesnim podacima relevantnim za očekivane okolnosti u modeliranim slučajevima. Također, implementira se pristup nesigurnosti u iznosima vrijednosti podataka u budućnosti, kako bi se vjerno prikazale nesigurnosti predviđanja. Ovaj pristup rješava problem ograničenja pomičnog horizonta u ispunjavanju sveobuhvatnih rubnih uvjeta. Nadalje, istraživanje se fokusira na integraciju različitih energetskih vektora te koristi umjetnu inteligenciju u svrhu pripreme ulaznih podataka. To primjerice omogućuje agregaciju krivulja potražnje preko različitih zona i proizvodnih jedinica u skladu s računalnim mogućnostima korištene opreme. U obzir se uzima smještaj komponenata unutar procesa proizvodnje e-goriva pri modeliranju višezonskih sustava. Očekivani ishodi projekta uključuju poboljšanu prilagodljivost modela energetskih sustava promjenjivim uvjetima, pouzdaniju integraciju varijabilne obnovljive energije i poboljšane kapacitete za dugoročno strateško planiranje. Konačno, ovaj projekt ima za cilj usavršiti energetske modele kako bi vjerno odražavali složenosti modernih energetskih sustava.]]></summary_hr><summary_en><![CDATA[This project addresses challenges in energy modelling and transition paradigm, particularly focusing on the electrification and decarbonization of hard-to-decarbonize sectors such as industry and transport. Proposed methodology shifts from traditional models with perfect foresight to a moving horizon approach, aided with artificial intelligence (AI). This method allows for 1) a dynamic response to different future contexts, and 2) a reduction in the computational demands and data intensity of current models, which have proven limiting in detailed examinations. Proposed approach offers greater flexibility in handling rapid changes in resource availability and unexpected environmental impacts, such as severe weather conditions, while adapting to hardware limitations. Predicted datasets are generated using deep learning neural networks trained on historical data relevant to the expected circumstances in the modelled cases. Also, a layer of uncertainty in the future curves and data is implemented to simulate forecast uncertainties over time, addressing limitations of moving horizon methods in meeting overarching restrictions. Furthermore, our research also explores the integration of various energy vectors and employs AI-driven preprocessing of input data to streamline modelling processes. This enables the aggregation of demand across different zones and generation units as required by the computational capabilities of available hardware. Consideration is given to the geographical placement of components within the e-fuel production process, given the modelling of multiple zones. The expected outcomes of AI-NPT project include improved adaptability of energy systems to variable conditions, more reliable integration of renewable energy, and enhanced capacity for long-term strategic energy planning. Ultimately, this project aims to refine energy models to accurately reflect the complexities of modern energy systems.]]></summary_en></project><project>
<id>17024</id><title_hr><![CDATA[Analiza plastičnosti dendritičkih trnova hipokampalnih zrnatih stanica nakon eksperimentalno inducirane denervacije u modelu miša]]></title_hr><title_en><![CDATA[Analysis of dendritic spine plasticity in hippocampal granule cells following experimentally induced denervation in the mouse model]]></title_en><user_id>3523</user_id><user_firstLast_name>Mario Vukšić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2024-05</proposal_call><code>IP-2024-05-5754</code><acronim><![CDATA[ADSPINE]]></acronim><duration>16.12.2024 - 15.12.2027</duration><status>U tijeku</status><financ_value>169.604,01 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>865422, 865657, 865690, </team_members_id><team_members_names><![CDATA[Dinko Smilović, Fran Božić Božić, Mario Zelić, ]]></team_members_names><keywords_hr><![CDATA[dendritički trnovi, hipokampalne zrnate stanice, entorinalna lezija, synaptopodin, oporavak]]></keywords_hr><keywords_en><![CDATA[dendritic spines, hippocampal granule cells, entorhinal lesion, synaptopodin, repair]]></keywords_en><summary_hr><![CDATA[Girus dentatus (DG) hipokampalne formacije (HPF) prima aferentne aksone iz entorinalne moždane kore (EC) putem vlakana perforantnog puta (PP) koja su glavni ulazni put u HPF. U DG zrnate stanice (GC) zaprimaju ove signale te su,stoga izrazito osjetljive na promjene i poremećaje cijele mreže; a što rezultira promjenama njihove morfologije (Diekmann i sur., 2006). U tom pogledu, sastavnice GC koje su posrednici takvih promjena su dendriti I njihovi pripadajući trnovi. Dendritički trnovi zrnatih stanica su postsinaptičke strukture gdje nastaju ekscitatorne glutamatergične sinapse te gdje se odvija prijenos signala iz PP. Ove strukture su vrlo dinamične te se njihova struktura mijenja ovisno o njihovoj funkciji na način da veliki trnovi imaju snažniju ekscitacijsku funkciju u odnosu na manje trnove (Alvarez i Sabatini, 2007). Unutar ovih struktura smještena su tri proteina od interesa: sinaptopodin (SP), aktivnošću reguliran protein povezan sa citoskeletom (Arc) i gefirin. SP je ključan za stabilnost dendritičkih (Yap i sur., 2020). Arc je uključen u organizaciju dugotrajne sinaptičke plastičnosti (Peebles i sur., Hap). Gefirin je marker inhibitornih sinapsi te njegova prisutnost na stabilnim dendritičkim trnovima omogućuje reverzibilnu inhibitornu modulaciju i kontrolu ekscitacije (Villa I sur., 2016). Cilj ovoga projekta je utvrditi neposredne i dugoročne promjene dendritičkih trnova zrnatih stanica u odgovoru na leziju EC kao model ozljede mozga (Vukšić i sur., 2011), presijecanjem PP kod divljih tipova i SP-KO mi§eva te žrtvovanjem istih 3, 7, 14 i 28 dana nakon lezije. Kombinirajući intracelularnu injekciju, imunofluorescenciju, konfokalnu mikroskoplju, analizu morfologije dendritičkih trnova, kolokalizaciju SP-a, Arc-a i gefirina te testova ponašanja omogućit će se praćenje reakcije živčanih stanica na ozljedu u kontroliranim uvjetima. Dobiveni podatci će dati uvid u osnovne principe strukture, funkcjje i plastičnosti živčanih stanica nakon ozijede.]]></summary_hr><summary_en><![CDATA[The dentate gyrus (DC) of the hippocampal formation (HPF) receives afferents from the entorhinal cortex (EC) through the perforant path (PP), which is the main input of the HPF. In the DG, granule cells (GC) receive this input and are therefore highly sensitive to changes and disruptions of this network, which are seen as changes in their morphology (Diekmann et al., 1996). In this regard, components of the GCs that exhibit those changes are dendrites and their associated dendritic spines. Spines of GCs are post-synaptic sites where excitatory, synapses are made, and where the input from the PP is transmitted. These structures are dynamic, and their structure changes with regard to their function, with bigger spines having a larger excitatory function compared to their smaller counterparts (Alvarez and Sabatini, 2007). Inside these structures are located proteins of interest: Synaptopodin (SP), Activity-regulated cytoskeleton-associated protein (Arc), and gephyrin. SP is crucial for the stability of dendritic spines (Yap et al., 2020). Arc organizes long-term synaptic plasticity (Peebles et al., 2010). Gephyrin is a marker of inhibitory synapses, and its presence on dendritic spines allows for reversible inhibitory modulation and control of excitation (Villa at al., 2016). The goal of this project is to determine the acute and chronic changes in spines of GCs in response to an EC lesion as a model of brain injury (Vukšić et al., 2011) by transecting PP in wild-type and SP-KO mice, which will be sacrificed at 3, 7, 14 and 28 days after the lesion.  Afterward, combining intracellular injections, immunofluorescence, confocal microscopy, and analysis of dendritic spine morphology as well as SP, Arc, and gephyrin co-localisation, and behavioural tests will allow us to follow how neurons react to injury in a controlled environment. The obtained data will provide insights into the basic principles of neuronal structure, function, and plasticity after injury. ]]></summary_en></project><project>
<id>17028</id><title_hr><![CDATA[Gorući problem onečišćenja zraka u obalnom području Jadrana: uvid u transformacije svojstava lebdećih čestica i njihova utjecaja na zdravlje ljudi i morski okoliš]]></title_hr><title_en><![CDATA[A burning issue of air pollution in the Adriatic coastal zone: insights into the ageing of aerosol properties and impacts on human and environmental health]]></title_en><user_id>84</user_id><user_firstLast_name>Sanja Frka Milosavljević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2024-05</proposal_call><code>IP-2024-05-6224</code><acronim><![CDATA[ADRIAirBURN]]></acronim><duration>11.12.2024 - 10.12.2027</duration><status>U tijeku</status><financ_value>199.910,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Interdisciplinarne prirodne znanosti, Kemija, Biologija, </scie_field_hr><scie_field_en>Interdisciplinary natural sciences, Chemistry, Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>867641, 437, 25777, 986, 12557, 1050, 17816, 5818, 868240, 5789, 17873, 25845, </team_members_id><team_members_names><![CDATA[Branka Miljevic, Danijela Šantić, Andrea Milinković, Tvrtko Smital, Dario Omanović, Ivan Mihaljević, Mislav Anić, Jasna Arapov, Frederic Chaux-Jukic, Sanda Skejić, Ana Cvitešić Kušan, Saranda Bakija Alempijević, ]]></team_members_names><keywords_hr><![CDATA[Izgaranje biomase, Lebdeće čestice, Atmosferske transformacije, Onečišćenje zraka, Morski fitoplankton, Ljudsko zdravlje, Požari]]></keywords_hr><keywords_en><![CDATA[Biomass burning, Aerosol, Atmospheric ageing, Air pollution, Marine phytoplankton, Human health, Wildfires]]></keywords_en><summary_hr><![CDATA[Scenariji klimatskih promjena predviđaju kontinuirano povećanje emisija uslijed izgaranja biomase (BB). To zahtijeva cjelovitu procjenu okolišnog utjecaja lebdećih čestica koje nastaju pod utjecajem BB (BBA), posebno njihove kemijski reaktivne i vremenski promjenjive organske frakcije (BBOA). Kako bi se bolje razumjeli budući dosezi promjena u okolišu, posebno važni za dinamična, ali i ranjiva obalna područja, nužna je interdisciplinarna znanstvena suradnja u području atmosferske kemije i modeliranja, kemije i biologije mora te toksikologije. Stoga, holističkim, multidisciplinarnim pristupom, ADRIAirBURN ima za cilj unaprijediti saznanja o fizikalno-kemijskim svojstvima BBA, posebice BBOA frakcije, i utjecaju njihovih atmosferskih transformacija na kvalitetu zraka, te na zdravlje ljudi i morski okoliš obalnih područja. Projekt je usmjeren na obalno područje Jadrana koje je izloženo visokom riziku od požara, a za koji je doseg utjecaja BB emisija generalno nepoznat. Za postizanje glavnih ciljeva projekta predlaže se fazni pristup: Faza I: Ispitati promjenjivost kvalitete zraka uslijed BB emisija u obalnom području Jadrana kroz modeliranje i terenski rad koji uključuje kontrolirane sezonske požare otvorenih prostora; Faza II: Bolje razumijeti promjene kemijskih svojstava BBA tijekom atmosferskog starenja kombiniranjem inovativnih laboratorijskih studija atmosferskih procesa u vodenoj fazi i atmosferskim simulacijskim komorama; Faza III: Procijeniti razvoj toksičnosti BBA tijekom atmosferskog starenja primjenom toksikoloških acelularnih i staničnih studija na granici zrak-tekućina i fitoplanktonskih monokultura relevantnih za ljudsko zdravlje i zajednicu morskog fitoplanktona. Primjenom najsuvremenijeg integralnog pristupa, implementacija ADRIAirBURN projekta doprinijet će smanjenju nesigurnosti u prikazu BBA u atmosferskim modelima, nužnim za pouzdane procjene utjecaja BBOA na klimu, zdravlje ljudi i okoliš u cjelini.]]></summary_hr><summary_en><![CDATA[Climate change scenarios predict a continuous increase in emissions from biomass burning (BB). This calls for a comprehensive assessment of the environmental impact of BB aerosol particles (BBA), especially their chemically reactive organic fraction (BBOA), which changes over time. To capture the extent of the future changing environment, especially in dynamic and vulnerable coastal zones, collaboration between different research fields is essential, including atmospheric chemistry, modelling, marine chemistry and biology, and toxicology. Therefore, with a holistic, multidisciplinary approach, ADRIAirBURN aims to enhance scientific knowledge on physico-chemical properties of BBA, focusing on BBOA, and how their aging in the atmosphere affects air quality, human health and marine environment in coastal zones. The project focuses on the Adriatic coast, prone to extreme fire hazards, where the impact of BB emissions remains largely unknown. To reach its goals, ADRIAirBURN proposes a comprehensive phased approach: Phase I: Investigate the variability of air quality affected by BB emissions in the Adriatic coastal area through modelling and fieldwork, considering controlled open BB events; Phase II: Understand the evolution of BBA chemical properties during atmospheric aging by combining novel aqueous-phase laboratory and chamber studies; Phase III: Assess the evolution of BBA toxicity during aging through toxicological acellular and cellular studies at the air-liquid interface and phytoplankton monocultures relevant to human health and marine phytoplankton community. By employing a state-of-the-art integral approach, ADRIAirBURN aims to reduce uncertainties in BBA representation in atmospheric models. This is crucial for understanding the extent of BBOA impacts on climate, human health and the environment.]]></summary_en></project><project>
<id>17031</id><title_hr><![CDATA[Procjena kogeneracijskog potencijala jadranskih algi u fikoremedijaciji toksičnih industrijskih otpadnih voda]]></title_hr><title_en><![CDATA[Assessment of the Adriatic Algae Cogeneration Potential in Toxic industrial Wastewater Phycoremediation]]></title_en><user_id>533</user_id><user_firstLast_name>Maria Blažina</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2024-05</proposal_call><code>IP-2024-05-8858</code><acronim><![CDATA[A3PhyCoTox]]></acronim><duration>20.12.2024 - 19.12.2027</duration><status>U tijeku</status><financ_value>191.935,00 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Biotehnologija, Interdisciplinarne biotehničke znanosti, </scie_field_hr><scie_field_en>Biotechnology, Interdisciplinary biotechnical sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>5520, 434, 29243, 26993, 26728, 467, 868688, 28141, </team_members_id><team_members_names><![CDATA[Tin Klanjscek, Maja Fafanđel, Ena Pritišanac, Nenad Bolf, Luka Žilić, Tamara Đakovac, Jela Vukadin, Ivana Čarapar, ]]></team_members_names><keywords_hr><![CDATA[Bioremedijacija otpadnih voda, proizvodnja biogoriva, ublažavanje klimatskih promjena, ekofiziološko modeliranje, mikroalge, ekotoksikologija]]></keywords_hr><keywords_en><![CDATA[Waste water remediation, biofuel production, climate change mitigation, ecophysiological modeling, microalgae, ecotoxicology]]></keywords_en><summary_hr><![CDATA[Remedijacija otpadnih voda (OV) mikroalgama može ponuditi ekološki prihvatljiviju i ekonomski održiviju alternativu konvencionalnoj obradi otpadnih voda. Dok bakterije proizvode, alge uklanjaju CO2 iz atmosfere, a opet imaju dovoljno visoke stope rasta i učinkovitosti asimilacije za proizvodnju bogate biomase koja se može koristiti u kogenerativnoj proizvodnji biogoriva, uz dodatnu prednost smanjenja eutrofikacije i recikliranja neobnovljivih hranjivih tvari. Korištenje mikroalgi u industrijskoj obradi OV-a je, međutim, otežano usljed njihove osjetljivosti na fluktuacije okolišnih uvjeta i toksičnosti OV-a. S projektom A3PICO3G ova je istraživačka skupina otkrila da neke alge mogu uspješno rasti u otpadnim vodama rafinerije nafte, no potrebna su dodatna istraživanja kako bi uporaba mikroalgi u bioremedijaciji bila ekonomski održiva. A3PHYCOTOX će uz iterativni eksperimentalni pristup koristiti ekofiziološko numeričko modeliranje kako bi uspostavio znanstvenu platformu za procjenu i maksimiziranje bioremedijacijskog potencijala odabranih vrsta mikroalgi autohtonih u sjevernom Jadranu. Istraživanje će se usredotočiti na kandidatske vrste prepoznate kroz A3PICO3G projekt kao najperspektivnije. Postojeći automatizirani sustav bioreaktora (PBR) u Centru za istraživanje mora koristit će se za provođenje eksperimenata rasta kandidatskih vrsta u rasponu uvjeta izloženosti svjetlu, nutrijentima i toksičnim tvarima relevantnim za OV iz INA-inog postrojenja rafinerije nafte. Numeričko modeliranje će se koristiti za in silico identifikaciju optimalnih strategija rasta i procjenu fikoremedijacijskog kapaciteta testiranih mikroalga. Konačno, kako bi se validirao model, projekt će ponuditi provjeru koncepta u skaliranom sustavu, a što će zauzvrat dati smjernice za ekonomsku održivost fikomedijacije u konceptu kogenerativnog biorafinacijskog procesa.]]></summary_hr><summary_en><![CDATA[Wastewater (WW) remediation by microalgae can offer a more ecologically friendly and economically sustainable alternative to conventional WW treatments. While bacteria produce, algae sequester CO2 from the atmosphere, and yet still have high enough growth rates and assimilation efficiencies to produce lucrative biomass that can be used in a cogenerative production of biofuels, with the added benefit of reducing eutrophication and recycling non-renewable nutrients. Utilising microalgae in industrial WW treatment is, however, difficult because of their sensitivities to environmental fluctuations and WW toxicity. With the A3PICO3G project this research group discovered that some algae can successfully grow on oil refinery WW, but additional research is necessary to make the use of microalgae in bioremediation economically sustainable. A3PHYCOTOX will utilize an iterative experimental and modelling approach to establish a scientific platform for assessment and maximization of bioremediation potential of selected microalgae species indigenous to Northern Adriatic. The research will focus on the most promising candidate species identified by A3PICO3G. An existing automated system of 4 bioreactors (PBRs) in Center for Marine Research will be used to run the growth experiments of the candidate species in the range of light, nutrient and toxicant exposure conditions relevant to WW from INA oil refinery plant. Modeling will be used for in silico identification of the optimal growth strategies, and estimate the microalgal WW phycoremediation capacity. Finally, the project will produce a proof of concept in an upscaled system to validate models, which in turn will give guidance for the  economic sustainability of the phycoremediation in the cogenerative biorefinery concept.]]></summary_en></project><project>
<id>17034</id><title_hr><![CDATA[Kolektivni i nelinearni sustavi: Egzaktne metode Feynmanovim diagramima]]></title_hr><title_en><![CDATA[Collective and Nonlinear Systems: Exact Feynman Diagrammatic Approaches]]></title_en><user_id>868099</user_id><user_firstLast_name>Andrey Mishchenko</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2024-05</proposal_call><code>IP-2024-05-2406</code><acronim><![CDATA[CollNonlin]]></acronim><duration>20.12.2024 - 19.12.2027</duration><status>U tijeku</status><financ_value>196.515,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, Matematika, </scie_field_hr><scie_field_en>Physics, Mathematics, </scie_field_en><institution_hr><![CDATA[Institut za fiziku]]></institution_hr><institution_en><![CDATA[Institute of Physics in Zagreb]]></institution_en><team_members_id>6532, 4962, 3159, 868481, 868545, 868552, 872947, </team_members_id><team_members_names><![CDATA[Ivan Balog, Zoran Rukelj, Mihael Srđan Grbić, Cesare Franchini, Nikolay Prokofiev, Tomislav Miškić, Stefano Ragni, ]]></team_members_names><keywords_hr><![CDATA[egzaktna sumacija Feynmanovih dijagrama, korelirani elektroni, umjetni Kondo sustavi, electron-fonon veyanje, nelinearnosti]]></keywords_hr><keywords_en><![CDATA[Feynman diagrams exact summation, Correlated electrons, Artificial Kondo systems, Electron-phonon coupling, Nonlinearity]]></keywords_en><summary_hr><![CDATA[Tehnološki zahtjevi za uređaje koji učinkovito mijenjaju jedan oblik energije u drugi (UME) impliciraju uporabu materijala u kojima postoji međuigra između konačne gustoće vodljivih nositelja naboja, velikog broja atomskih magnetskih momenata te fonona kristalne rešetke. Primjerice, snažno međudjelovanje između itinerantnih elektrona i lokalnih spinskih momenata ključna je značajka spintroničkih uređaja, koji su u stanju pretvarati električnu u spinsku struju i obrnuto. Takvo međudjelovanje nedavno je uspješno implementirano na umjetnim Kondo rešetkama, u kojima vodljivi elektroni međudjeluju s raznovrsnim strukturama lokaliziranih spinova, u rasponu od spinskih otoka do periodičnih rešetki. Druga interesantna vrsta UME-a temelji se na halidnim perovskitima s jakim nelinearnim vezanjem na rešetku, čineći ih potencijalnim fotovoltaičnim i multiferroičnim materijalima za optoelektroniku i spintroniku.Zajednička značajka sustava koje želimo teorijski istražiti u kontekstu UME je ne postojanje malog parametara za perturbativno modeliranje jakog miješanja između različitih stupnjeva slobode materijala. Od strane PI-ja i suradnika nedavno su razvijene metode egzaktnog zbrajanja Feynmanovih dijagrama (Dijagramatski Monte Carlo) i dobivanja optičkih i transportnih svojstava materijala preko stohastičkog analitičkog produljenja. Ove metode su egzaktne i ključne za dobivanje svojstava materijala koji služe za UME.Projekt ima za cilj daljnji razvoj egzaktnih metoda za proučavanje važnih problema za koje je pouzdan teorijski tretman ključan za razvoj materijala za UME: (1) Kondo rešetke u fizikalnim sustavima i umjetnim uređajima; (2) optička svojstva i mobilnost polarona pri konačnim gustoćama; (3) svojstva osnovnog stanja, elektronski fotoemisijski i optički apsorpcijski spektri u granici niskih gustoća u sustavima s različitim vrstama nelinearnog elektron-fononskog vezanja. Složenost fizike sustava pretvarača jednostavno ne oprašta aproksimacije.]]></summary_hr><summary_en><![CDATA[Technological demands for the transducers, i.e., devices effectively changing one form of energy into another, imply the usage of materials characterized by an interplay between a finite density of charge carriers, a large array of atomic magnetic moments, and lattice phonons. As an example, strong interaction between itinerant electrons and large local spins is the key feature of spintronics devices, transforming between the charge and the spin current. Such interplay was recently implemented in artificial Kondo Lattice systems, in which conduction electrons interact with various structures of localized spin, spanning from spin islands to periodic lattices. Other kinds of transducers that are of interest are based on halide perovskites, with a strong nonlinear coupling to the lattice, making them prospective photovoltaic and multiferroic materials for optoelectronics and spintronics. The feature common for transducers that we want to investigate, is the absence of natural small parameters for theoretical modeling of strong mixing between different degrees of freedom. Recently, methods of exact summation of Feynman diagrams (Diagrammatic Monte Carlo) and obtaining the optical and transport properties of materials from summation procedure (Stochastic Analytic Continuation) were developed by PI and collaborators. These methods are approximation-free and crucial for achieving reliable predictions of transducer material behaviors.The project aims to develop further exact methods for studying important problems in which reliable theoretical treatment is crucial for the development of transducer materials: (1) Kondo Lattice properties in natural systems and artificial devices; (2) optical properties and mobilities of finite density polarons; (3) ground state properties, photoemission and optical absorption spectra of low-density systems with various kinds of nonlinear electron-phonon interactions. The complexity of transducers’ physics does not forgive approximations. ]]></summary_en></project><project>
<id>17039</id><title_hr><![CDATA[Prijenos signala ljudskim tijelom za nosive i implantabilne sustave]]></title_hr><title_en><![CDATA[Intrabody Communication for Wearable and Implantable Systems]]></title_en><user_id>21443</user_id><user_firstLast_name>Željka Lučev Vasić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2024-05</proposal_call><code>IP-2024-05-2808</code><acronim><![CDATA[IBIS]]></acronim><duration>09.12.2024 - 08.12.2027</duration><status>U tijeku</status><financ_value>197.579,75 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, Interdisciplinarne tehničke znanosti, </scie_field_hr><scie_field_en>Electrical engineering, Interdisciplinary technological sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>12596, 865105, 865102, 868578, 869556, 870690, 872982, </team_members_id><team_members_names><![CDATA[Darko Vasić, Matija Roglić, Antonio Stanešić, Yueming Gao, Antonio Bandur, Azadeh Yadollahi, Luka Klaić, ]]></team_members_names><keywords_hr><![CDATA[Prijenos signala ljudskim tijelom, mjerenje prijenosne karakteristike, elektromagnetski modeli, elektronička sučelja, ugradbeni računalni sustavi]]></keywords_hr><keywords_en><![CDATA[Intrabody communication, transfer characteristic measurement, electromagnetic models, electronic interfaces, embedded systems]]></keywords_en><summary_hr><![CDATA[U komunikaciji putem ljudskog tijela (eng. intrabody communication, IBC) čovjek postaje dio prijenosnog puta signala između odašiljača i prijamnika smještenih na površini kože, u njezinoj blizini ili implantiranih unutar korisnikovog tijela. IBC sustavi koriste niže frekvencijsko područje od standardnih bežičnih sustava te imaju nižu potrošnju energije i niži domet. IBC kanal se mijenja dinamički s promjenom konfiguracije i položaja elektroda, ispitanikom i njegovim kretnjama te okolinom. Potencijalne primjene IBC-a su vrlo široke: od biotelemetrije i medicine do komunikacije između različitih elektroničkih uređaja i sigurnosnih sustava.U ovom projektnom prijedlogu planiramo istražiti mehanizme prijenosa IBC kanala za nosive i implantabilne sustave u širokom frekvencijskom području. Ključni ciljevi uključuju mjerenja prijenosnih karakteristika i utjecajnih parametara IBC kanala, modeliranje mehanizama prijenosa signala ljudskim tijelom, kao i projektiranje i izvedbu senzorskih sučelja i ugradbenih računalnih sustava niske potrošnje. Radi ostvarivanja ciljeva projekta naša istraživačka grupa planira implementirati novi pristup modeliranju, kombinirajući mjerenja i modeliranja svih utjecajnih parametara u IBC kanalima. Novorazvijena IBC sučelja, sa standardnim ili tekstilnim elektrodama, će se koristiti za karakterizaciju odgovarajućih komunikacijskih kanala prema predloženoj eksperimentalnoj metodologiji. Ispitivanja će se provesti na raznolikoj skupini sudionika, na fantomima ljudskog tijela (tekući, gel i životinjski modeli) i svinjskom mesu u nekoliko specifičnih okolina. Na temelju dobivenih rezultata će se dati generalne smjernice za izvedbu IBC uređaja, koje će se verificirati tijekom razvoja vlastitih prototipova IBC uređaja i senzorskih sučelja, namijenjenih za dvije primjene prijenosa signala ljudskim tijelom s oprečnim zahtjevima – jedna sa zahtjevom na nisku potrošnju (kemijski senzori, mjerenje bioimpedancije), a druga na visoku brzinu prijenosa podataka.]]></summary_hr><summary_en><![CDATA[In an intrabody communication (IBC) system the human body is used as a part of a communication channel between the transmitters and receivers placed on or near the skin, or implanted within the user’s body. IBC systems use lower frequency band than standard wireless systems, and they have lower power consumption and lower range. IBC channel changes dynamically with electrode configuration and positions, subject, subject’s movements, and surrounding environment. Possible applications of IBC are very broad: from biotelemetry and medicine to the communication between various electronic devices and security systems.This proposal seeks to investigate the transmission mechanisms of the IBC channel for both wearable and implantable systems in a broad frequency range. Key objectives include characterizing IBC channel transmission characteristics and influential parameters, developing simulation models for intrabody communication, and designing sensor interfaces and low-power embedded systems. To achieve these objectives, our research group plans to implement novel modelling approaches, combining measurements and modelling of all influential parameters in IBC channels. We will utilize novel IBC interfaces, featuring standard or textile electrodes, to characterise respective IBC transmission channels based on the proposed experimental methodology. Experiments will be conducted on a diverse group of individuals, on human body phantoms (liquid, gel, and animal models) in several specific environments. Combining obtained results, general guidelines for IBC devices design will be given and verified during the development of proprietary prototypes of IBC devices and sensor interfaces for two groups of IBC applications with opposing requirements – one requiring low power consumption (chemical sensing, bioimpedance monitoring), and the other requiring high data rate communication.]]></summary_en></project><project>
<id>17040</id><title_hr><![CDATA[Niskotemperaturna eutektička otapala i njihova primjenjivost u stabilizaciji i isporuci proteina]]></title_hr><title_en><![CDATA[Deep eutectic solvents and their applicability for stabilization and delivery of proteins]]></title_en><user_id>3228</user_id><user_firstLast_name>Ivana Radojčić Redovniković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2024-05</proposal_call><code>IP-2024-05-9948</code><acronim><![CDATA[DESsolvProt]]></acronim><duration>09.12.2024 - 08.12.2027</duration><status>U tijeku</status><financ_value>199.982,47 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Biotehnologija, Interdisciplinarne biotehničke znanosti, </scie_field_hr><scie_field_en>Biotechnology, Interdisciplinary biotechnical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Food Technology and Biotechnology]]></institution_en><team_members_id>5279, 5443, 19708, 6112, 4129, 865178, 868548, 872922, 866662, 872921, 6126, </team_members_id><team_members_names><![CDATA[Višnja Gaurina Srček, Kristina Radošević, Igor Slivac, Marko Rogosic, Mario Rakić, Martina Bagović, Anastasia Detsi, Matija Cepanec, Anja Damjanović, Martina Železnjak, Marina Cvjetko Bubalo, ]]></team_members_names><keywords_hr><![CDATA[niskotemperaturna eutektička otapala, proteini, stabilnost, isporuka, eutektogelovi, lizozim, inzulin]]></keywords_hr><keywords_en><![CDATA[deep eutectic solvents, proteins, stability, delivery, eutectogels, lysozyme, insulin]]></keywords_en><summary_hr><![CDATA[Proteini imaju ključnu ulogu u različitim industrijskim granama, poput prehrambene, biotehnološke i kozmetičke, čineći osnovu za razne proizvode te u razvoju terapija i lijekova. Međutim, izazovi poput nestabilnosti proteina tijekom skladištenja i isporuke, potiču akademsku i industrijsku zajednicu  na razvoj novih stabilnih proteinskih formulacija za sigurnu i kontroliranu dostavu lijeka.Niskotemperaturna eutektička otapala (Deep Eutectic Solvents, DES) su netoksična, biorazgradiva i visoko prilagodljiva otapala koja učinkovito stabiliziraju biomolekule poput proteina. Ova otapala također pokazuju antioksidativna i antimikrobna svojstva, što ih čini privlačnima za primjenu u farmaceutskoj industriji. Stoga je farmaceutska industrija izrazito zainteresirana za DES-ove kao osnove za stvaranje novih proizvoda, s obzirom na njihovu svestranu ulogu i slaganje sa strogim regulatornim standardima.Na temelju navedenog, glavni cilj projekta je dizajn stabilnih tekućih formulacija na bazi DES-ova odnosno eutektogelova za stabilizaciju proteina. Istraživanje podrazumijeva dvije ključne faze: (i) dizajniranje biokompatibilnih DES-ova i eutektogelova za očuvanje funkcionalnost proteina kroz probir različitih DES-ova primjenom eksperimentalnih i računalnih metoda te (ii) razvoj stabilnih tekućih formulacija na bazi DES-ova odnosno eutektogelova za isporuku proteina, osiguravajući njihovu visoku bioraspoloživost i biološku aktivnost. Stečena saznanja o primjenjivosti DES-ova i eutektogelova u stabilizaciji i isporuci proteina predstavljat će značajan iskorak prema industrijskoj implementaciji ovih otapala, ne samo u farmaceutskoj industriji već i u drugim industrijskim granama koji se oslanjaju na tehnologije temeljene na proteinima.]]></summary_hr><summary_en><![CDATA[Proteins play a crucial role in industries such as food, biotechnology, and cosmetics, forming the basis for products and advancements in therapy and drug development. However, challenges like protein instability during storage and administration persist, prompting research efforts to develop stable protein formulations for safe and controlled drug delivery.Deep Eutectic Solvents (DES) are non-toxic, biodegradable, and highly customizable solvents that effectively stabilize biomolecules such as proteins. These solvents also demonstrate antioxidant and antimicrobial properties, making them appealing for drug delivery applications. Therefore, the pharmaceutical industry is enthusiastic about utilizing DES to create new products, given their versatility and capacity to meet stringent regulatory standards.Based on the aforementioned points, the main objective of the project is to design stable liquid formulations based on DES and eutectogels for protein stabilization. This involves two key research phases: (i) designing biocompatible DES and eutectogels that preserve protein functionality through screening various DES candidates using experimental and computational methods, and (ii) developing stable DES-based liquid or eutectogel formulations for protein delivery, ensuring high bioavailability and biological activity of the proteins.The knowledge gained about the applicability of DES and eutectic gels in protein stabilization and delivery will represent a significant step forward towards the industrial implementation of these solvents, not only in the pharmaceutical industry but also in other sectors relying on protein-based technologies.]]></summary_en></project><project>
<id>17043</id><title_hr><![CDATA[Autonomni ugradbeni senzorski čvor za ispitivanje vrtložnim strujama]]></title_hr><title_en><![CDATA[Autonomous embedded sensor node for eddy current testing]]></title_en><user_id>12596</user_id><user_firstLast_name>Darko Vasić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2024-05</proposal_call><code>IP-2024-05-4331</code><acronim><![CDATA[AENECT]]></acronim><duration>09.12.2024 - 08.12.2027</duration><status>U tijeku</status><financ_value>192.330,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>19300, 24508, 18917, 869552, </team_members_id><team_members_names><![CDATA[Davorin Ambruš, Dorijan Špikić, Ratko Magjarević, Leonardo Max Golušin, ]]></team_members_names><keywords_hr><![CDATA[nerazorno ispitivanje, ispitivanje vrtložnim strujama, numerički elektromagnetizam, senzorska sučelja, ugradbeni senzorski sustav, strojno učenje]]></keywords_hr><keywords_en><![CDATA[non-destructive testing (NDT), eddy current testing (ECT), computational electromagnetism, sensor interface, embedded sensor system, machine learning]]></keywords_en><summary_hr><![CDATA[Rutinsko i planirano nerazorno ispitivanje i evaluacija integriteta, značajki i kvalitete materijala, komponenti, sustava ili struktura bez oštećenja ili umanjivanja korisnosti objekta je ključno u osiguranju sigurnosti, pouzdanosti i kvalitete u svim industrijskim granama. Ispitivanje vrtložnim strujama je među najvažnijim metodama nerazornog ispitivanja. Promjena paradigme iz rutinskog i planiranog ispitivanja u kontinuirano ispitivanje vrtložnim strujama najkritičnijih struktura je izazovna zbog potrošnje senzorskog sustava i sudjelovanja ljudi u interpretaciji podataka. Oba ograničenja se mogu zadovoljiti ugradbenom izvedbom senzorskog sustava s malom potrošnjom, smanjivanjem količine odaslanih podataka i stavljanjem težišta na strojnu obradu podataka u blizini senzora. Ovim projektom se doprinosi istraživanju koncepta autonomne mreže inteligentnih senzora za kontinuirani nadzor sigurnosno kritičnih industrijskih komponenti ili struktura metodom vrtložnih struja. Opći cilj projekta je istražiti metode realističnog simuliranja senzora vrtložnih struja i tehnika integracije simulatora s algoritmima strojnog učenja u ugradbenom sustavu male potrošnje. Glavni rezultat projekta je demonstrator ugradbenog senzorskog sustava za autonomno ispitivanje vrtložnim strujama. Tijekom projekta istraživački tim će izvesti prošireni analitički model i razviti simulator senzora vrtložnih struja i senzorskog sučelja, istražiti mjernu metodu zasnovanu na interakciji senzora vrtložnih struja i objekta tijekom prilaza senzora objektu, te razviti algoritme strojnog učenja za analizu podataka senzora vrtložnih struja i istražiti izvedbu u ugradbenom senzorskom sustavu male potrošnje.]]></summary_hr><summary_en><![CDATA[Routine and planned non-destructive testing and evaluation of the integrity, characteristics, and quality of materials, components, systems, or structures without damaging or diminishing their usefulness is essential in ensuring safety, reliability, and quality across industries. Eddy current testing is among the most important methods of non-destructive testing. The challenges in shifting the paradigm from routine and planned testing to continuous eddy current testing of critical structures lie in the energy consumption of the sensor system and the need for human involvement in data interpretation. Both limitations can be addressed by implementing low-power embedded sensor systems, reducing the amount of data transmitted, and focusing on machine processing of data near the sensor. This project contributes to the research of an autonomous network of intelligent sensors for the continuous monitoring of safety-critical industrial components or structures using the eddy current method. The overall objective of the project is to explore methods for the realistic simulation of eddy current sensors and techniques for integrating a sensor system simulator with machine learning algorithms in a low-power embedded system. The main outcome of the project is a demonstrator of an embedded sensor system for autonomous eddy current testing. During the project, the research team will develop an expanded analytical model and implement a simulator of the eddy current sensor and sensor interface, design a measurement method based on the interaction of the eddy current sensor and the object during the sensor’s approach to the object, develop machine learning algorithms for the analysis of the eddy current sensor data, and investigate the implementation of these algorithms in a low-power embedded sensor system.]]></summary_en></project><project>
<id>17044</id><title_hr><![CDATA[Radiološki utjecaj teških nesreća u nuklearnim elektranama na okoliš i lokalno stanovništvo]]></title_hr><title_en><![CDATA[Radiological impact of severe accidents in nuclear power plants on the environment and the local population]]></title_en><user_id>29692</user_id><user_firstLast_name>Siniša Šadek</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2024-05</proposal_call><code>IP-2024-05-4011</code><acronim><![CDATA[RUNOLIST]]></acronim><duration>16.12.2024 - 15.12.2027</duration><status>U tijeku</status><financ_value>131.560,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Interdisciplinarne tehničke znanosti, Elektrotehnika, Temeljne tehničke znanosti, </scie_field_hr><scie_field_en>Interdisciplinary technological sciences, Electrical engineering, Basic engineering sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>7241, 6070, 17764, 29547, 868537, 6827, </team_members_id><team_members_names><![CDATA[Davor Grgić, Krešimir Trontl, Paulina Družijanić, Vesna Benčik, Petra Strmečki, Mario Matijević, ]]></team_members_names><keywords_hr><![CDATA[nuklearna elektrana, teške nesreće, oštećenje jezgre, radioaktivni ispust, doza zračenja, kvantifikacija neodređenosti]]></keywords_hr><keywords_en><![CDATA[nuclear power plant, severe accidents, core damage, radioactive release, radiation dose, uncertainty quantification]]></keywords_en><summary_hr><![CDATA[Nesreća u nuklearnoj elektrani Fukushima potaknula je mnoge elektrane da provedu modifikacije za unapređenje sigurnosti, kao i da se unaprijede programi pripravnosti za slučaj teške nesreće. Iako u Hrvatskoj nema nuklearnih elektrana, ova je problematika itekako važna s obzirom da se u našoj neposrednoj okolici nalazi pet nuklearnih elektrana, jedna u Sloveniji, a četiri u Mađarskoj. Cilj projekta je procijeniti realno stanje ugroženosti populacije u Hrvatskoj i izračunati primljene doze za slučaj nesreće u obližnjoj elektrani. U početnoj fazi će se napraviti pregled svih mogućih nesreća s teških posljedicama i selektirati najteži kvarovi korištenjem determinističkog i probabilističkog pristupa. Nakon toga će se pripremiti model jezgre reaktora za ocjenu inventara radioaktivnog materijala. Integralna analiza propagacije nesreće u reaktorskoj posudi, primarnom i sekundarnom krugu elektrane, te u reaktorskoj zgradi obuhvatit će sve puteve ispusta i transporta radionuklida unutar podsustava elektrane. Rezultat će biti podatak o mjestu i iznosu radioaktivnog ispusta iz nuklearne elektrane u okoliš. Model atmosferske disperzije koristit će realne meteorološke podatke za procjenu koncentracija radionuklida na širem geografskom području. Konačno će se ti podaci iskoristiti za određivanje efektivne ekvivalentne doze zračenja koju primi ugroženo stanovništvo. Kako se u svim fazama izračuna pojavljuju veće ili manje neodređenosti vezane uz neprecizne početne i rubne uvjete, napravit će se računalni alat koji će pomoći u kvantifikaciji neodređenosti, određivanju mjera važnosti i procjeni kritičnih parametara za određivanje veličine radioaktivnog ispusta i utjecaja na stanovništvo.]]></summary_hr><summary_en><![CDATA[The accident at the Fukushima nuclear power plant prompted many power plants to implement safety-enhancing modifications, as well as to improve their major accident preparedness programs. Although there are no nuclear power plants in Croatia, this issue is very important considering that there are five nuclear power plants in our immediate vicinity, one in Slovenia and four in Hungary. The aim of the project is to assess the real state of threat to the population in Croatia and calculate the doses received in case of an accident at a nearby power plant. In the initial phase, an overview of all possible accidents with severe consequences will be made and the most severe failures will be selected using a deterministic and probabilistic approach. After that, a model of the reactor core will be prepared for the evaluation of the radioactive material inventory. An integral analysis of the propagation of the accident in the reactor vessel, the primary and secondary circuit of the power plant, and in the reactor building will cover all the paths of release and transport of radionuclides within the subsystem of the power plant. The result will be information on the location and amount of radioactive discharge from the nuclear power plant into the environment. The atmospheric dispersion model will use realistic meteorological data to estimate radionuclide concentrations over a wider geographic area. Finally, these data will be used to determine the effective equivalent dose of radiation received by the vulnerable population. As greater or lesser uncertainties related to imprecise initial and boundary conditions appear in all phases of the calculation, a computer tool will be created that will help in the quantification of uncertainties, determination of measures of importance and assessment of critical parameters for determining the size of the radioactive release and impact on the population.]]></summary_en></project><project>
<id>17060</id><title_hr><![CDATA[Uvid u rasprostranjenost toksičnih tvari u ekosustavu mora analizom dagnji naprednim spektrometrijskim i kromatografskim analitičkim tehnikama]]></title_hr><title_en><![CDATA[Insight into the bioaccumulation of toxic substances in mussels using advanced spectrometric and chromatographic analytical techniques]]></title_en><user_id>3130</user_id><user_firstLast_name>Ivana Ujević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2024-05</proposal_call><code>IP-2024-05-9464</code><acronim><![CDATA[BioToks ]]></acronim><duration>16.12.2024 - 15.12.2027</duration><status>U tijeku</status><financ_value>109.084,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Interdisciplinarne prirodne znanosti, Kemija, </scie_field_hr><scie_field_en>Interdisciplinary natural sciences, Chemistry, </scie_field_en><institution_hr><![CDATA[Institut za oceanografiju i ribarstvo]]></institution_hr><institution_en><![CDATA[Institute of Oceanography and Fisheries]]></institution_en><team_members_id>15951, 866460, 6741, 6093, 862776, 868480, 871159, </team_members_id><team_members_names><![CDATA[Romana Roje Busatto, Nikša Nazlić Nazlić, Jelena Lušić, Stjepan Orhanović, Antonija Bulić, Ivana Pezelj, Roman Garber, ]]></team_members_names><keywords_hr><![CDATA[Biotoksini, metali u tragovima,policiklički aromatski ugljikovodici,UHPLC, AAS,DMA,LC-MS/MS,UHPLC-QTOF,masena spektrometrija visoke rezolucije,dagnje ]]></keywords_hr><keywords_en><![CDATA[biotoxins, trace metals, polycyclic aromatic hydrocarbons, UHPLC, AAS, LC-MS/MS, UHPLC-QTOF, high resolution mass spectrometry, mussels, Adriatic Sea]]></keywords_en><summary_hr><![CDATA[U ekosustavu mora mogu se nakupljati antropogeni ili prirodni kontaminanti. More može biti onečišćeno biotoksinima, metalima, policikličkim aromatskim ugljikovodicima (PAH) i drugim kontaminantima. Razmjeri onečišćenja znatno su naglašeniji zbog ljudskih djelatnosti, a imaju utjecaj na zdravlje ljudi, gospodarske djelatnosti i sam ekosustav. Biotoksine najčešće proizvode neke vrste fitoplanktona koje se u pogodnim okolišnim uvjetima brzo razmnožavaju te unose veliku količinu biotoksina u ekosustav. Ti biotoksini se u najvećoj mjeri nakupljaju u organizmima koji se hrane filtriranjem mora poput dagnji. Zbog načina ishrane, široke rasprostranjenosti i sesilnog načina života dagnje su pogodan indikatorski organizam za praćenje stanja okoliša. Trovanja ljudi događaju se nakon konzumacije kontaminiranih školjkaša i rezultiraju različitim simptomima od blagih do letalnih. Do sada je zabilježena pojava lipofilnih i hidrofilnih toksina u svim dijelovima Jadrana. Poznat je velik broj analoga biotoksina, a razvoj novih, naprednih analitičkih tehnika pridonosi kontinuiranom otkrivanju novih analoga. Ekosustav mora može biti onečišćen unosom metala i PAH-ova što se može evidentirati praćenjem njihove pojave u indikatorskom organizmu kao što je dagnja. Novije studije povezuju izloženost PAH-ovima s različitim negativnim učincima na morske organizme i ljude. Ekstrakti prikupljenih dagnji prirodnih i uzgojnih populacija će se ciljano analizirati na poznate kontaminante, a primjenom masene spektrometrije visoke rezolucije provesti će se i neusmjerena analiza kako bi se detektirali mogući novi analozi i nepoznati toksini. Ista tehnika će se primjenom SWATH analize koristiti i za pripremu digitalnog zapisa svih komponenti uzorka koji će se moći retrospektivno pretraživati za eventualne buduće spojeve od interesa. Praćenje statusa toksičnih spojeva u moru doprinosi značajno očuvanju morskih resursa na kojima se temelji čitav niz gospodarskih djelatnosti.]]></summary_hr><summary_en><![CDATA[Anthropogenic or natural pollutants can accumulate in the marine ecosystem. The sea can be polluted with biotoxins, metals, polycyclic aromatic hydrocarbons (PAH), and other contaminants. Pollution is much more pronounced due to human activities, affecting human health, economic activities, and the ecosystem itself. Biotoxins are most commonly produced by certain phytoplankton species, which reproduce rapidly under favorable environmental conditions and introduce a large amount of biotoxins to the ecosystem. These biotoxins accumulate to the greatest extent in filter feeding organisms, such as mussels. Due to way they feed, wide distribution, and sessile lifestyle, mussels are a suitable indicator organism for monitoring the state of the environment. Poisoning in humans occurs after the consumption of contaminated shellfish and results in poisoning with symptoms ranging from mild to fatal.  Many biotoxin analogues are known, and the development of new advanced analytical techniques contributes to the continuous discovery of new analogues. The marine ecosystem can be polluted by metals and PAHs, the presence of which can be tracked in an indicator organism such as a mussel. Recent studies have linked exposure to PAHs to various adverse effects on marine organisms and humans. Extracts of collected mussels from natural and cultured populations will be analyzed for known contaminants, and untargeted analysis will be performed using high-resolution mass spectrometry to detect possible new analogues and unknown toxins. The same technique will be used to prepare a digital record of all components in the sample through the use of SWATH analysis, allowing a retrospective search for possible future compounds of interest. Monitoring the status of toxic compounds in the sea contributes significantly to the conservation of marine resources, on which a whole range of economic activities are based.]]></summary_en></project><project>
<id>17063</id><title_hr><![CDATA[Predikcija i generiranje RNA tercijarnih struktura metodama temeljenima na dubokom učenju]]></title_hr><title_en><![CDATA[Deep Learning-Based RNA Tertiary Structure Prediction and Generation]]></title_en><user_id>1480</user_id><user_firstLast_name>Mile Šikić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2024-05</proposal_call><code>IP-2024-05-1554</code><acronim><![CDATA[RNAi]]></acronim><duration>20.12.2024 - 19.12.2027</duration><status>U tijeku</status><financ_value>199.000,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>864963, 868305, 868436, 870624, </team_members_id><team_members_names><![CDATA[Tin Vlašić, Rafael Josip Penić, Roland Huber, Fran Globlek, ]]></team_members_names><keywords_hr><![CDATA[umjetna inteligencija, RNA, predviđanje, struktura, generative models]]></keywords_hr><keywords_en><![CDATA[arteficial inteligence , RNA, prediction, structure, generativni modeli]]></keywords_en><summary_hr><![CDATA[RNA je dugo bila zanemarena kao potencijalna meta za razvoj lijekova zbog nedostatka detaljnog razumijevanja strukture. Međutim, ova se percepcija mijenja kako se njezin značaj sve više prepoznaje, posebno imajući u vidu da nekodirajuće RNA čine znatan dio genoma, između 70% i 75%. Slično proteinima, RNA molekule usvajaju složene tercijarne strukture koje kontroliraju različite fazama njihovog životnog ciklusa, uključujući transkripciju, translaciju, degradaciju i transport. Pojava alata baziranih na umjetnoj inteligenciji, osobito u određivanju strukture proteina kao što je AlphaFold2, zajedno sa sve većim znanjima o zamršenim obrascima savijanja molekula i potencijalu RNA molekule u razvoju novih lijekova, ponovno je potaknuo interes u akademskoj zajednici i industriji. Unatoč tome, ostaju značajne prepreke u prilagodbi alata sličnih proteinima za točno predviđanje tercijarnih struktura RNA. Ovaj prijedlog projekta ima za cilj riješiti te izazove i steći duboko razumijevanje ograničenja trenutnih pristupa temeljenih na dubokom učenju u predviđanju tercijarnih struktura RNA, kao i razvoju novih metoda. Naš pristup uključuje naš nedavno razvijen RNA veliki jezični model RiNALMo koji ćemo koristiti kao ulaznu značajku za predviđanje strukture. RiNALMo je pokazao iznenađujuće generalizacijske sposobnosti kada smo ga prilagodili predviđanju sekundarne strukture. Povrh toga, istražit ćemo i razvoj dubokih generativnih metoda za modeliranje konformacijskog prostora molekula RNA i dizajn tercijarnih struktura RNA. Vjerujemo da će razvijene metode imati važan utjecaj na strukturnu biologiju, posebno za razvoj novih lijekova fokusiranih na RNA molekulu.]]></summary_hr><summary_en><![CDATA[RNA has long been neglected as a potential target for drug development due to a lack of detailed structural understanding. However, this perception is changing as its significance is increasingly acknowledged, particularly considering that non-coding RNAs make up a substantial portion of the genome, ranging from 70% to 75%. Similar to proteins, RNAs adopt complex tertiary structures that exert control over various stages of their life cycle, including transcription, translation, degradation, and transportation. The advent of AI-driven tools, notably in protein structure determination such as AlphaFold2, coupled with growing insights into the intricate folding patterns and druggability of RNA, has reignited interest across academia and industry. Nevertheless, significant hurdles remain in adapting protein-like tools for accurately predicting RNA tertiary structures. This project proposal aims to address these challenges and gain a profound understanding of the limitations of current deep-learning approaches in predicting RNA tertiary structures as well as developing new methods. Our approach involves our recently developed RNA large language model RiNALMo as an input to structure prediction. RiNALMo showed surprising generalization when we fine-tuned it to the secondary structure prediction. Moreover, on top of this, we will explore the development of deep generative methods for modeling the conformational space of RNA molecules and designing RNA tertiary structures. We believe the developed methods will have an important impact on structural biology, especially for drugging RNA.]]></summary_en></project><project>
<id>17066</id><title_hr><![CDATA[Ispitivanje in-situ i ex-situ tehnika obnove naselja smeđih algi reda Fucales]]></title_hr><title_en><![CDATA[Restoration exploration for fucalean species: In-situ and ex-situ approaches]]></title_en><user_id>775</user_id><user_firstLast_name>Ljiljana Iveša</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2024-05</proposal_call><code>IP-2024-05-2362</code><acronim><![CDATA[REFINE]]></acronim><duration>16.12.2024 - 15.12.2027</duration><status>U tijeku</status><financ_value>183.925,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Interdisciplinarne prirodne znanosti, Biologija, </scie_field_hr><scie_field_en>Interdisciplinary natural sciences, Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>862761, 866679, 868331, 866070, 27011, </team_members_id><team_members_names><![CDATA[Andrea Bilajac, Edi Gljušćić, Thomas Wernberg, Shannen Smith, Emma Cebrian, ]]></team_members_names><keywords_hr><![CDATA[red Fucales, praćenje stanja, reproduktivna fenologija, ex-situ kultivacija, in-situ obnova]]></keywords_hr><keywords_en><![CDATA[fucalean forests, monitoring, reproductive phenology, ex-situ cultivation, in-situ restoration]]></keywords_en><summary_hr><![CDATA[Šume makroalgi predstavljaju jedne od najproduktivnijih i najraznolikijih ekosustava na Zemlji koji pružaju kritične usluge ekosustava. Međutim, one proživljavaju globalnu regresiju ukazujući na rastuću potrebu za zaštitom i obnovom. Naš projekt teži ka sveobuhvatnoj procijeni stanja te unapređenju znanja u svrhu učinkovitije zaštite šuma fukoidnih algi u sjevernom Jadranu. Prvo planiramo provesti opsežna terenska istraživanja kako bismo ocijenili trenutnu rasprostranjenost i brojnost poznatih, povijesno poznatih i još neistraženih fukoidnih zajednica. Usporedbom najnovijih nalaza s povijesnim i recentnijim opažanjima, nastojimo prepoznati promjene u njihovim obrascima rasprostranjenosti kroz vrijeme. Nadalje, planiramo analizirati morfološke karakteristike i fiziološko stanje vrsta u fukoidnim zajednicama u različitim staništima. Analizom tih parametara želimo bolje shvatiti kako različiti ekološki čimbenici utječu na karakteristike i stanje tih zajednica. Zatim ćemo istražiti reproduktivnu fenologiju fukoidnih vrsta u različitim staništima, s ciljem da opišemo načine kako okolišni uvjeti utječu na njihove reproduktivne cikluse. Te su informacije ključne za unaprjeđenje strategija očuvanja i obnove ovih zajednica. Temeljem tih spoznaja, planiramo unaprijediti postojeće te neke novo osmišljene ex-situ i in-situ metode obnove fukoidnih naselja primjenjujući ih u tri različita staništa: mediolitoralnim lokvicama, plitkom infralitoralu i u urbaniziranim obalnim područjima. Ovakva evaluacija će nam omogućiti testiranje učinkovitosti tih metoda u obnavljanju fukoidnih naselja u njihovim prirodnim, ali i antropogenim staništima, koja na nekim mjestima još uvijek nastanjuju. U konačnici, naš projekt povezuje terenska istraživanja, laboratorijske eksperimente te inovativne pristupe ka obnovi staništa fukoidnih algi, kako bi pridonio naporima za očuvanje i obnovu morskih šuma u sjevernom Jadranu i šire, doprinoseći tako očuvanju ukupne morske bioraznolikosti.]]></summary_hr><summary_en><![CDATA[Macroalgal forests represent some of the most productive and diverse ecosystems on Earth and support critical ecosystem goods and services. However, they are experiencing a global decline, which stresses the need for prioritizing conservation and restoration initiatives. The goal of REFINE is to assess and enhance the conservation of fucalean forests in the northern Adriatic. Firstly, we will conduct extensive field surveys to evaluate the current distribution and abundance of known, suspected and unsurveyed fucalean communities. By comparing historical records with recent observations, we seek to understand temporal variations in their distribution patterns. Next, we will analyse the abundance, morphological traits, and physiological status of fucalean species among diverse habitats. This analysis will provide insights into how different ecological factors impact the characteristics and well-being of these communities. Furthermore, we will investigate the reproductive phenology of fucalean species across different habitats in order to understand how environmental conditions influence their reproductive cycles. This information will be crucial for developing more effective conservation strategies. Building on these findings, we will improve upon already piloted and some newly developed ex-situ and in-situ restoration approaches by applying them in three different habitats: rockpools, shallow subtidal, and urban coastal areas. This evaluation will help us determine the effectiveness of these methods in restoring fucalean forests in their natural, but also more urbanised environment, in which they are still found. Overall, our project combines field surveys, laboratory experiments, and innovative restoration approaches, contributing to the overall marine forest conservation and restoration efforts in the northern Adriatic and beyond, contributing to the conservation of marine biodiversity in the wider region.]]></summary_en></project><project>
<id>17086</id><title_hr><![CDATA[Radionička proizvodnja i uvoz u 8. i 9. stoljeću na području sjeverne Dalmacije]]></title_hr><title_en><![CDATA[The 8th and 9th century workshop production and imports at the territory of Northern Dalmatia]]></title_en><user_id>7828</user_id><user_firstLast_name>Mirja Jarak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2024-05</proposal_call><code>IP-2024-05-4611</code><acronim><![CDATA[Medievalworkshops]]></acronim><duration>10.12.2024 - 09.12.2027</duration><status>U tijeku</status><financ_value>149.990,00 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Arheologija, Povijest, Povijest umjetnosti, Interdisciplinarne humanističke znanosti, </scie_field_hr><scie_field_en>Archeology, History, Art history, Interdisciplinary humanities, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>23974, 868020, 11321, 868016, 868192, 23939, 867794, 5547, 867354, 873047, </team_members_id><team_members_names><![CDATA[Ante Uglešić, Maja Petrinec, Tomislav Fabijanić, Ozana Martinčić, Šime Perović, Željko Krnčević, Petra Jeršek, Ana Maričić, Damir Doračić, Ivo Ćevid, ]]></team_members_names><keywords_hr><![CDATA[sjeverna Dalmacija, 8. i 9. stoljeće, radionice, keramika, metalni, koštani i stakleni nalazi, tekstil, kameni spomenici, arheometrija]]></keywords_hr><keywords_en><![CDATA[Northern Dalmatia, 8th and 9th century, workshops, ceramics, metal, bone and glass artefacts, textile, stone monuments, archaeometry]]></keywords_en><summary_hr><![CDATA[Projektni  prijedlog &#39;&#39;Radionička proizvodnja i uvoz u 8. i 9. stoljeću na području sjeverne Dalmacije&#39;&#39; uključuje istraživanje različitih tipova arheoloških nalaza koje povezuje osnovno istraživačko pitanje o mogućnostima preciznog utvrđivanja radioničkog porijekla. To podrazumijeva detaljnije spoznaje o regionalnim dalmatinskim ranosrednjovjekovnim radionicama, kao i sigurnije atribucije pojedinih nalaza određenim stranim radionicama.U projektu će se prikupljati podaci o elementnom sastavu, tehnologiji i tragovima izrade metalnih, keramičkih, kamenih, staklenih, koštanih i tekstilnih nalaza. Osim primjene klasičnog vizualnog pregleda i korištenja fotoaparata, podaci će se prikupljati pomoću raznih uređaja kojima će upravljati članovi projektnog tima i zaposlenici laboratorija vanjskih institucija, što jamči kvalitetu provedenih analiza i interpretacija.Spomenute analize omogućit će cjelovite spoznaje o nalazima i otkriti razlike između radionica koje su djelovale ili bile povezane s područjem sjeverne Dalmacije u 8. i 9. stoljeću. Predloženo istraživanje treba rezultirati znanjem o porijeklu predmeta i detaljima radioničkih obilježja proizvodnje, što je još nepoznato. Projektni rezultati trebali bi predstavljati osnovu za šire kontekstualne interpretacije ranosrednjovjekovne arheološke baštine s područja sjeverne Dalmacije, njezino bolje razumijevanje i vrednovanje.]]></summary_hr><summary_en><![CDATA[The project proposal “The 8th and 9th century workshop production and imports at the territory of Northern Dalmatia“ includes research into different types of archaeological findings connected by the basic research question on the possibility of precise determination of artefacts workshop origin. That implies a detailed knowledge of the regional Dalmatian early medieval workshops and secure atribution of particular findings to certain foreign workshops.In the project data on the elemental composition, technology and traces of production of metal, ceramic, stone, glass, bone and textile artefacts will be collected. In addition to visual inspection and the use of a digital camera, data will be collected using various devices managed by team members and experts from the laboratories of external institutions, which guarantees the quality of the performed analyses and interpretations.The mentioned analyses will provide a comprehensive knowledge on objects in question and reveal the differences in production due to different workshops that operated or were associated with the region of northern Dalmatia in the 8th and 9th century. The proposed research should  provide a reliable knowledge on the origin of the finds and details of  work of individual workshops, that are currently unknown.The results  should serve as a basis for broader contextual interpretations of the early medieval archaeological heritage from the northern Dalmatia territory and its better understanding and evaluation.]]></summary_en></project><project>
<id>17090</id><title_hr><![CDATA[Inovativni pristupi u razvoju imidazola za zaštitu bilja]]></title_hr><title_en><![CDATA[Innovative Approaches in the Development of Imidazoles for Plant Protection]]></title_en><user_id>4982</user_id><user_firstLast_name>Vesna Rastija</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2024-05</proposal_call><code>IP-2024-05-6164</code><acronim><![CDATA[DIPP INN]]></acronim><duration>16.12.2024 - 15.12.2027</duration><status>U tijeku</status><financ_value>199.900,00 eur</financ_value><scie_area_hr>Biotehničke znanosti, Prirodne znanosti, </scie_area_hr><scie_area_en>Biotechnical sciences, Natural sciences, </scie_area_en><scie_field_hr>Kemija, Poljoprivreda, </scie_field_hr><scie_field_en>Chemistry, Agriculture, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Fakultet agrobiotehničkih znanosti Osijek]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Agrobiotechnical Sciences in Osijek]]></institution_en><team_members_id>1248, 1259, 26711, 20511, 2700, 26692, 4919, 23983, 25851, 28956, 866604, 866603, 866608, 866602, 29540, 25321, 872848, </team_members_id><team_members_names><![CDATA[Jasenka Ćosić, Karolina Vrandečić, Ivana Majić, Gabriella Kanižai Šarić, Dejan Agić, Ankica Sarajlić, Martina Šrajer Gajdošik, Marija Paurević, Maja Karnaš, Domagoj Šubarić, Milan Vraneš, Jovana Panić, Teona Teodora Borović, Snežana Papović, Andrea Dandić, Marija Kristić, Helena Ereš, ]]></team_members_names><keywords_hr><![CDATA[organska sinteza, derivati imidazola, okolišno prihvatljiv, zaštita bilja, inhibicija kolinesteraze, QSAR, molekulsko uklapanje]]></keywords_hr><keywords_en><![CDATA[organic synthesis, imidazole derivatives, environmentally acceptable, plant protection, cholinesterase inhibition, QSAR, molecular docking]]></keywords_en><summary_hr><![CDATA[Pesticidi su iznimno važni u poljoprivrednoj proizvodnji u borbi protiv štetnika, bolesti i korova. Prema uredbi Europske unije  o stavljanju sredstava za zaštitu bilja na tržište (EZ) br. 1107/2009), sredstva za zaštitu bilja trebaju sadržavati samo tvari za koje je dokazano da predstavljaju jasnu korist za biljnu proizvodnju i da se ne očekuje da će imati bilo kakav štetan učinak na zdravlje ljudi ili životinja ili bilo kakav neprihvatljiv učinak na okoliš.  Imidazoli su učinkoviti pesticidi, ali samo nekolicini je Europska komisija dozvolila uporabu. Cilj ovog projekta je sintetizirati derivate imidazole koji bi bili učinkovite aktivne tvari sredstava za zaštitu bila, ali sigurna za okoliš i zdravlje ljudi. Novi spojevi dizajnirat će se temeljem procjene toksičnosti primjenom računalnih metoda i prvenstveno sintetizirati principima “zelene kemije”. Ispitat će se djelovanje novih derivata imidazola na predstavnicima zemljišno korisnih te fitopatogenih gljiva, bakterija, nematoda i insekata. Budući da je djelovanje pojedinih aktivnih sastojaka sredstava za zaštitu bilja povezano s inhibicijom enzima kolinesteraze, koji su važni za normalnu funkciju živčanog sustava kod ljudi, drugih kralježnjaka i kod kukaca, provest će se in vitro test inhibicije ova dva enzima. Odnos strukture i aktivnosti (SAR) i studija kvantitativne strukture aktivnosti (QSAR) primjenjivat će se u dizajnu novih derivata imidazola. Metodom molekulskog uklapanja identificirat će se način interakcije između aktivne molekule i ciljnog enzima ili proteina koji je povezan s promatranom biološkom aktivnošću. Konačni cilj projekta je predložiti nova aktivnu komponentu budućeg sredstva za zaštitu bilja koja je prihvatljiva u integriranoj zaštiti bilja.]]></summary_hr><summary_en><![CDATA[Pesticides play a crucial role in agriculture by combating pests, diseases, and weeds. According to the European Union regulation on placing plant protection products on the market (EC) No. 1107/2009), only substances that have been proven to represent a clear benefit for crop production and are not expected to have any adverse effect on human or animal health or any unacceptable effect on the environment.  Imidazoles are an effective pesticide, but only a few were approved by the EC. This project aims to synthesize imidazole derivatives, effective active substances of protective agents, and safe for the environment and human health. This project represents the initial phase of pesticide discovery involving a rational synthesis based on a chemoinformatic approach that enables the preliminary screening of molecules for toxicity and environmental effects. New compounds will be designed based on toxicity assessment using computer methods, and synthesized primarily according to the principles of &#39;&#39;green chemistry&#39;&#39;. The effect of new imidazole derivatives on representatives of soil-beneficial and phytopathogenic fungi, bacteria, nematodes, and insects will be tested. Since the action of some active components of plant protection products is related to the inhibition of the enzymes cholinesterases, which are important for the normal function of the nervous system in humans, other vertebrates, and insects, in vitro inhibition assay of these two enzymes will be performed. The structure-activity relation and quantitative-structure activity study studies will be applied in the design of novel derivatives of imidazole. Molecular docking will be used to identify the mode of interaction between the active molecule and the target enzyme or protein that is associated with the observed biological activity. The final objective of the project is to propose a new active component of the future plant protection product that is acceptable in integrated plant protection.]]></summary_en></project><project>
<id>17097</id><title_hr><![CDATA[Kvaliteta života osoba starije odrasle dobi s problemima vidnog funkcioniranja]]></title_hr><title_en><![CDATA[Quality of Life of Older Adults with Visual Functioning Problems]]></title_en><user_id>26342</user_id><user_firstLast_name>Sonja Alimović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2024-05</proposal_call><code>IP-2024-05-2162</code><acronim><![CDATA[QoL4OAwVFP]]></acronim><duration>20.12.2024 - 19.12.2027</duration><status>U tijeku</status><financ_value>180.256,66 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Edukacijsko-rehabilitacijske znanosti, </scie_field_hr><scie_field_en>Physical education and rehabilitation sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Edukacijsko-rehabilitacijski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Education and Rehabilitation Sciences]]></institution_en><team_members_id>24192, 868318, 26504, 868389, 867808, 868463, 872704, </team_members_id><team_members_names><![CDATA[Tina Runjic, Matea Luburić, Dominik Sikirić, Vlatka Anić, Andrea Paulik, Sonja Drugović, Lorena Koštić, ]]></team_members_names><keywords_hr><![CDATA[Vidno funkcioniranje, Kvaliteta života, Osobe starije odrasle dobi, Neovisno življenje, Osobna zdravstvena pismenost ]]></keywords_hr><keywords_en><![CDATA[Visual functioning, Quality of Life, Older Adults, Independent Living, Personal Health Literacy ]]></keywords_en><summary_hr><![CDATA[Procjenjuje se kako će se populacija osoba starije odrasle dobi u svijetu udvostručiti do 2050. godine. Osobe starije od 65 godine češće razvijaju probleme u vidnom funkcioniranju koji ostaju neprepoznati. Zbog navedenih problema, osobe su sklonije ozljedama, socijalnoj izolaciji i ovisnosti o drugima. Stoga je neophodno razvijati znanstveno utemeljene programe koji će pridonijeti pravovremenom prepoznavanju problema vidnog funkcioniranja u ove populacije, ali i programe koji će pridonijeti prevenciji posljedica problema vidnog funkcioniranja. Stoga u ovom istraživanju planiramo ispitati specifičnosti vidnog funkcioniranja osoba starije odrasle dobi, njihovu kvalitetu života, osobnu zdravstvenu pismenost u području vidnog funkcioniranja i neovisnost kako bismo razvili program podrške i edukacije ovih osoba baziran na znanstvenim činjenicama. Po završetku programa isti će biti evaluiran primjenom znanstvene metodologije. Rezultati ovog istraživanja predstavljat će bazu za razvoj novih znanstvenih spoznaja u području čimbenika kvalitete života osoba starije odrasle dobi s problemima vidnog funkcioniranja, kao i razvoj novih socijalnih usluga. ]]></summary_hr><summary_en><![CDATA[It is estimated that the population of older adults in the world will double by 2050. Individuals older than 65 more often develop problems in visual functioning that remain unrecognized. Due to the mentioned problems, people are more prone to injuries, social isolation and dependence on others. Therefore, it is necessary to develop scientifically based programs that will contribute to the timely detection of visual functioning problems in this population, but also programs that will contribute to the prevention of the consequences of visual functioning problems. Therefore, in this research we plan to examine the specifics of the visual functioning of older adults, their quality of life, personal health literacy in area of visual functioning and independence in order to develop scientifically based support and education program for older adults with visual functioning problems. Upon completion, the program will be evaluated using scientific methodology. The results of this research will represent the basis for the development of new scientific knowledge about the factors influencing the quality of life in older adults with visual functioning problems, as well as the development of new social services for this population. ]]></summary_en></project><project>
<id>17109</id><title_hr><![CDATA[Analiza tanatomikrobioma: implementacija foremzičke mikrobiologije u proces obdukcije]]></title_hr><title_en><![CDATA[Thanatomicrobiome analysis: implementation of forensic microbiology in autopsy process]]></title_en><user_id>26681</user_id><user_firstLast_name>Bojana Mohar Vitezić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2024-05</proposal_call><code>IP-2024-05-5732</code><acronim><![CDATA[Thanatomicrobiome]]></acronim><duration>09.12.2024 - 08.12.2027</duration><status>U tijeku</status><financ_value>180.320,00 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Kliničke medicinske znanosti, Javno zdravstvo i zdravstvena zaštita, </scie_field_hr><scie_field_en>Clinical sciences, Public health and health services, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Medicine]]></institution_en><team_members_id>27179, 868623, 868627, 866153, 2659, 867494, 26460, 12375, 868662, </team_members_id><team_members_names><![CDATA[Christophe Štemberger, Kristina Franjić, Tinka Mohar Hajnšek, Tomaž Zupanc, Marina Bubonja Šonje, Ira Renko, Gabrijela Begić, Dolores Peruč, Katja Lipošćak, ]]></team_members_names><keywords_hr><![CDATA[Tanatomikrobim, forenzička mikrobiologija, obdukcijski protokoli, antemortem infekcije, identifikacija patogena]]></keywords_hr><keywords_en><![CDATA[Thanatomicrobime, forensic microbiology, autopsy protocols,  antemortem infection, pathogen identification]]></keywords_en><summary_hr><![CDATA[ Forenzička mikrobiologija (FM) novo je i nedavno uspostavljeno područje. Novije analize mikrobioma, koje se temelje na poboljšanim sekvencijskim platformama, poduprijete su novim bioinformatičkim i statističkim alatima. Tanatomikrobiom se sastoji od mikroorganizama koji su uglavnom prisutni u krvi i unutarnjim organima. Upotreba FM  je novi i važan dio procesa autopsije. Infekcija može biti antemortem prisutna ili se u nju sumnja, u tom slučaju  FM može pomoći u utvrđivanju uloge patogena u uzroku smrti. Pri provođenju postmortalne analize i obdukcije bolesnika sa sumnjom na infekciju nejasne etiologije, usporedba antemortem kliničkih laboratoriskih nalaza s postmortem uzetim mikrobiološkim uzorcima, pomogla bi u formuliranju diferencijalne dijagnoze i usmjeravanju daljnjeg forenzičkog istraživanja. Takve metagenomske studije rijetke su i provedene na samo 3 vrste tkiva. Nedostatak istraživanja u opisanom području FM, potiče nas da proširimo istraživanje na tanatomikrobiom. Svrha našeg istraživanja je optimizacija i standardizacija SOP-a (minimizacija kontaminacije) prikupljanja uzoraka za forenzičku mikrobiologiju tijekom obdukcija. Prikupljanje  podataka o tanatomikrobiomu iz različitih vrsta tkiva (u kontroliranim uvjetima u kratkom postmortem razdoblju. Translacija dobivenih metagenomskih podataka i povezivanje s kliničkom anamnezom i nalazima.pojedinca. Usporedba antemortem nalaza i postmortem rezultata uzetih uzoraka, potvrda ili moguća identifikacija uzročnika antemortem infekcije, procjena njegove kliničke važnosti te utvrđivanje njegove uloge u uzroku smrti. Interdicciplinarna studija poput ove omogučava iskorak u translacijkoj medicini, omogučavajući interakcije temeljnih i kliničkih istraživanja sa svakodnevnom medicinskom praksom. Omogućiti će razmjenu znanja i njegovo prevođenje u kliničku primjenu u svrhu poboljšanja patološke dijagnostike i postupaka. Upoznavanje mikrobiologa s FM također će omogućiti implementaciju novih metoda u mikrobiologiju.]]></summary_hr><summary_en><![CDATA[Forensic microbiology (FM) is a new and recently established field. Newer analyzes of the microbiome, which are based on improved sequencing platforms, are supported by new bioinformatics and statistical tools. Thanatomicrobiome (TM) consists of microorganisms that are mainly present in the blood and internal organs. The use of FM is a new and important part of the autopsy process. Infection may be present or suspected antemortem, in which case FM can help establish the role of the pathogen in the cause of death. When conducting a postmortem analysis and autopsy of a patient with infection of unclear etiology, a comparison of antemortem laboratory findings with postmortem microbiological results would help in formulating a differential diagnosis and directing further research. Such metagenomic studies are rare and were performed on only 3 tissue types. Researches  deficit in FM described above, prompts us to extend our research to definition of the TM. The purpose of our research is to optimize and standardize the SOP (minimizing contamination) of collecting samples for forensic microbiology during autopsies. Collection of data on the TM from different tissue types (under controlled conditions in a short postmortem period).  Metagenomic data analysis and connection with clinical history and findings of the individual. Comparison of antemortem findings and postmortem results of samples taken, confirmation or identification of the cause of antemortem infection, assessment of its clinical importance and determination of its role in the cause of death. This interdisciplinary study enables a breakthrough in translational medicine, enabling interaction of basic and clinical research with medical practice. It will enable knowledge exchange and its translation into clinical application for the purpose of improving pathological diagnostics and procedures. Introducing microbiologists with FM will also enable the implementation of novel diagnostic methods in microbiology.]]></summary_en></project><project>
<id>17111</id><title_hr><![CDATA[Nepeludni palinomorfi i palinofacijes u rekonstrukciji paleookoliša ]]></title_hr><title_en><![CDATA[Non-pollen palynomorphs and palynofacies in paleoenvironmental reconstruction]]></title_en><user_id>3511</user_id><user_firstLast_name>Koraljka Bakrač</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2024-05</proposal_call><code>IP-2024-05-1687</code><acronim><![CDATA[Non-Poll]]></acronim><duration>16.12.2024 - 15.12.2027</duration><status>U tijeku</status><financ_value>179.590,00 eur</financ_value><scie_area_hr>Prirodne znanosti, Humanističke znanosti, </scie_area_hr><scie_area_en>Natural sciences, Humanities, </scie_area_en><scie_field_hr>Geologija, Fizika, Biologija, Arheologija, </scie_field_hr><scie_field_en>Geology, Physics, Biology, Archeology, </scie_field_en><institution_hr><![CDATA[Hrvatski geološki institut]]></institution_hr><institution_en><![CDATA[Croatian Geological Survey]]></institution_en><team_members_id>22653, 865001, 26617, 4262, 3956, 944, 12960, 13192, 24095, 867523, 870233, </team_members_id><team_members_names><![CDATA[Dario Hruševar, Ivona Baniček, Božena Mitić, Anita Grizelj, Danijel Ivanišević, Ankica Oros Sršen, Zdravka Hincak, Danijela Roksandić Vukadin, Dinko Radić, Luka Bakrač, JAN HINKELMAN, ]]></team_members_names><keywords_hr><![CDATA[palinologija, nepeludni palinomofi, palinofacijes, paleookoliš, arheologija]]></keywords_hr><keywords_en><![CDATA[palynology, non-pollen palynomorphs, palynofacies, paleoenvironment, archeology]]></keywords_en><summary_hr><![CDATA[U svijetu, pa tako i u Hrvatskoj, postoji veliki interes za rekonstrukciju paleookoliša i paleoklime kroz proučavanje paleovegetacije. Ako je u sedimentu prisutno dovoljno sporomorfi (spore, pelud), možemo lako rekonstruirati klimu i okoliš. Međutim, u nedostatku sporomorfi, analiza preostalih mikroskopskih ostataka s organskim stjenkama, tj. palinofacijesa i nepeludnih palinomorfi (NPP) također može dati važne tragove za rekonstrukciju paleookoliša. Palinofacijes predstavlja ukupni organski ostatak sedimenta dok su nepeludni palinomorfi (NPP) mikrofosili različitog podrijetla (biljke/životinje/alge/gljive) pronađeni u palinološkim preparatima u rasponu veličina peludnih zrnaca (10-250 µm). Zajednica nepeludnih palinomorfa može ukazivati na uvjete okoliša u vrijeme taloženja i može se koristiti kao pokazatelj antropogenog utjecaja, a vrlo je korisna činjenica da se nalaze u svim vrstama sedimenata, od morskih do kopnenih, uključujući špiljske sedimente i arheološke artefakte. Projekt će se usredotočiti na identifikaciju i interpretaciju NPP i palinofacijesa uzoraka iz sedimentnih sukcesija i arheološkog materijala gdje je bilo nedovoljno biljnih ostataka. Primjenjivost NPP-a i palinofacijesa u rekonstrukciji paleookoliša testirat će se na dva pilot područja, uključujući špilju Vela spila iznad Vele Luke (Korčula) i arheološko nalazište Vučedol. Integrirat ćemo palinološku, mineralošku, petrološku, geokemijsku i sedimentološku analizu kako bismo pružili kompleksno razumijevanje okolišnih procesa. Posebna pozornost posvetit će se tafonomskim procesima i podrijetlu recentne kontaminacije koja može promijeniti palinofacijesne obrasce i dovesti do pogrešnih zaključaka u rekonstrukciji okoliša. Ishodi projekta mogu doprinijeti i prirodnim i humanističkim znanostima (arheologiji) i poboljšati naše znanje o promjenama u okolišu koje su se dogodile u prošlosti  i interakcijama čovjeka i prirode.]]></summary_hr><summary_en><![CDATA[In the world, as well as in Croatia, there is a great interest in paleoenvironmental and paleoclimate reconstruction through the study of past vegetation. If enough sporomorphs (spores, pollen) are present in the sediments, we can easily reconstruct climate and environments. However, in the absence of sporomorphs, the analysis of the remaining organic-walled microscopic remains i.e. palynofacies and non-pollen palynomorphs (NPP) can give also important clues for paleoenvironmental reconstruction. Palynofacies represents the total organic residue of sediments, while non-pollen palynomorphs (NPP) are microfossils of diverse origin (plants/animals/algae/funghi) found in palynological slides in the size of pollen grains (10–250 µm). Their association can indicate environmental conditions at the time of deposition and can be used as indicator of anthropogenic influence. They are found in all types of sediments, from marine to terrestrial including cave sediments and archeological artefacts. The project will focus on the identification and interpretation of NPPs and palynofacies patterns from sedimentary successions and archeological material where the abundance of vascular plant remains was insufficient. The applicability of NPPs and palynofacies in paleoenvironmental reconstruction will be tested on two case studies including the Vela spila cave above Vela Luka (Korčula) and the Vučedol archeological site. We will integrate palynological, mineralogical, petrological, geochemical and sedimentological analysis in order to provide a complex understanding of environmental processes. Special attention will be paid to taphonomic processes and the origin of recent contamination that can alter palynofacies patterns and lead to erroneous conclusions in environmental reconstruction. The project outcomes can contribute to both natural and human sciences (archeology) and improve our knowledge of past environmental changes and human-nature interactions.]]></summary_en></project><project>
<id>17113</id><title_hr><![CDATA[Komparativna proteomska analiza specifičnih klasa neurona subtalamičke jezgre ]]></title_hr><title_en><![CDATA[Comparative proteomic analysis of the specific subclasses of subthalamic neurons]]></title_en><user_id>4125</user_id><user_firstLast_name>Goran Sedmak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2024-05</proposal_call><code>IP-2024-05-8297</code><acronim><![CDATA[PROTSTAN]]></acronim><duration>20.12.2024 - 19.12.2027</duration><status>U tijeku</status><financ_value>199.900,00 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>7740, 13232, 866446, 4108, 17841, 25257, 868256, 868275, </team_members_id><team_members_names><![CDATA[Miloš Judaš, Ruđer Novak, Tila Medenica Medenica, Lovorka Grgurević, Andrija Štajduhar, Ema Bokulić, Slavica Martinovic, Anton Mažuranić, ]]></team_members_names><keywords_hr><![CDATA[subtalamička jezgra, proteom, neuralne subpopulacije, komparativna neuroanatomija, ljudski mozak]]></keywords_hr><keywords_en><![CDATA[subthalamic nucleus, proteome, neural subpopulations, comparative neuroanatomy, human brain]]></keywords_en><summary_hr><![CDATA[Subtalamička jezgra (STN) je mala, konveksna jezgra smještena u dinecefalonu. STN je ključna struktura bazalnih ganglija, s bitnom ulogom u regulaciji motoričkih funkcija. STN je kompleksna jezgra koja prima projekcije iz mnogih moždanih područja (moždane kore, diencefalona, mezencefalona), te je sastavljena od projekcijskih (glutamatergičkih) i lokalnih (GABAergičkih) neurona. Zanimljivo je da postoje značajne razlike u prostornoj raspodijeli i sastavu aksona koji STN prima te i u vrstama neurona prisutnim u STN. Npr. interneuroni su dokazani jedino u ljudskom mozgu, dok kod drugih životinjskih vrsta nedostaju. Posljednjih godina STN je postala važna terapijska struktura kod duboke mozgovne stimulacije (npr. Parkinsonova bolest, bolesti ovisnosti, Touretteov sindrom, itd.), te ključna struktura za razumijevanje patogeneze mnogih bolesti (npr. Parkinsonova bolest, Huntingtonova bolest, distonije, itd.).Zbog svoje ključne uloge u motoričkoj kontroli, razumijevanje molekularne i stanične građe STN je ključno za otkrivanje patogeneze poremećaja pokreta te razvoja efikasnih terapijskih postupaka. Komparativna proteomska analiza pruža nam moćan alat u istraživanju specifičnih neuronskih podskupina u STN, te razotkrivanju molekularnog profila i funkcijskih karakteristika koje razlikuju ovih neuronske podskupina unutar iste vrste te između vrsta.U ovom znanstvenom projektu cilj nam je provesti sveobuhvatnu komparativnu proteomsku analizu pojedinačnih neuronskih podskupina STN, te otkriti molekularne razlike i sličnosti koje su podloga različitih funkcija ovih neuronskih podskupina. Istraživanjem proteomskog krajolika STN, produbiti ćemo naše razumijevanje njezine uloge u motoričkoj kontroli. Također, dobiveni podaci mogu nam pomoći u poboljšanju dostupnih terapija za poremećaje pokreta]]></summary_hr><summary_en><![CDATA[The subthalamic nucleus (STN) is small, convex nucleus located in the diencephalon. STN is a key structure of basal ganglia, with an important role of regulating motor function. STN receives projections from various brain regions (cerebral cortex, diencephalon, mesencephalon) and is composed of projection (glutamatergic) and local (GABAergic) neurons. It is interesting to note that there are significant differences in spatial distribution and composition of afferent STN axons, and in the neuronal subclasses that are present in the STN. For example, interneurons are only found in the human STN, while other analysed species lack interneurons. In recent years STN has become important therapeutic structure for deep brain stimulation (e.g. Parkinson disease, addiction, Tourett syndrome, etc.), and key structure for understanding pathogenesis of many disorders (e.g. Parkinson disease, Huntington disease, dystonia, etc.).Due to its key role in motor control, understanding of molecular and cellular composition of the STN is key in revealing pathogenesis of movement disorders and development of effective therapeutic procedures. Comparative proteomic analysis provides us with powerful tool in exploration of specific neuronal subgroups in the STN and elucidating molecular profile and functional characteristics of these subgroups within the species and between different species.In this project we will undertake encompassing comparative proteomic analysis individual neuronal subgroups in the STN and elucidate molecular differences and similarities which are basis of various functions of these neuronal subgroups. By investigating proteomic landscape of the STN, we will deepen our understanding of its role in motor control. Furthermore, collected data can help us to enhance available therapeutic procedures for movement disorders.]]></summary_en></project><project>
<id>17117</id><title_hr><![CDATA[Coffee ring&#39; efekt &#39;Lab on a Chip&#39; okruženja u razvoju novih formulacija lijekova]]></title_hr><title_en><![CDATA[Coffee ring&#39; effect in &#39;Lab on a Chip&#39; environments in the development of new drug formulations.]]></title_en><user_id>26087</user_id><user_firstLast_name>Ernest Meštrovic</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2024-05</proposal_call><code>IP-2024-05-4339</code><acronim><![CDATA[CORE4PHARM]]></acronim><duration>20.12.2024 - 19.12.2027</duration><status>U tijeku</status><financ_value>197.678,35 eur</financ_value><scie_area_hr>Prirodne znanosti, Tehničke znanosti, Biomedicina i zdravstvo, </scie_area_hr><scie_area_en>Natural sciences, Technological sciences, Biomedicine and health sciences, </scie_area_en><scie_field_hr>Kemija, Kemijsko inženjerstvo, Farmacija, Interdisciplinarne prirodne znanosti, Interdisciplinarne tehničke znanosti, </scie_field_hr><scie_field_en>Chemistry, Chemical engineering, Pharmaceutical sciences, Interdisciplinary natural sciences, Interdisciplinary technological sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet kemijskog inženjerstva i tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Chemical Engineering and Technology]]></institution_en><team_members_id>2809, 866338, 158, 864918, 867603, 872901, </team_members_id><team_members_names><![CDATA[Snežana Miljanić, Ivona Jasprica, Iva Rezić, Sara Krivačić, Željka Boček, Donna Danijela Dragun, ]]></team_members_names><keywords_hr><![CDATA[formulacije, lijekovi, coffee ring efekt, samoorganizirajući sustavi, Inkjet tehnologija, mikrokapljice, Ramanova spektroskopija]]></keywords_hr><keywords_en><![CDATA[formulations, drugs, coffee ring effect, self-organizing systems, inkjet technology, microdroplets, Raman spectroscopy]]></keywords_en><summary_hr><![CDATA[Samoorganizirajući sustavi predstavljaju ključ za razumijevanje kompleksnih sustava s jedne strane a s druge daju mogućnost istraživanja niza  interakcija. U ovom projektu cilj je iskoristiti pojavu &#39;&#39;coffee ring&#39;&#39; efekta za razvoj novih protokola za evaluaciju kandidata za lijekove u ranim fazama otkrića, poboljšavajući učinkovitost i ekonomičnost u istraživanju i razvoju lijekova. Istraživanje je fokusirano na samoorganizirajuće motive, posebno koristeći tehnologiju temeljenu na inkjet printerima za precizno nanošenje uzorak u obliku mikrokapljica. Koristeći specijalizirane uređaje, tradicionalan ručni način pripreme uzoraka koje obično uključuje stotine pokusa po formulaciji može se proširiti na tisuće. Ova ekspanzija omogućava provođenje opsežnih eksperimenata s minimalnom količinom materijala, što je ključno u ranim fazama istraživanja gdje je dostupnost materijala vrlo ograničena.  Predloženi tehnološki i znanstveni  napreci uključuju sistematsku analizu podataka, što je središnji dio projekta. Upotreba različitih tehnika mikroskopije, kao što su optička mikroskopija i mikroskopija elektronskim skeniranjem (SEM), igra ključnu ulogu u ovoj fazi, pružajući uvide u strukturna i morfološka svojstva uzoraka. Ramanova spektroskopija nudi kemijsku karakterizaciju na mikroskopskoj razini, ključnu za razumijevanje svojstava i određivanje interakcija što je ključ u osmišljavanju formulacija.  Dalje, projekt istražuje integraciju strojnog učenja s mikroskopskom analizom kako bi se poboljšalo predviđanje farmaceutskih svojstava i performansi. Napredni algoritmi mogu analizirati slike kako bi detektirali uzorke i značajke koje klasične metode ne mogu odrediti što omogućuje dublje razumijevanje kako fizikalna i kemijska svojstva utječu na ponašanje i stabilnost lijekova. Cilj je razviti platformu koja će omogućiti da se ovim postupkom steknu spoznaje na nekoliko miligrama djelatne tvari za što bi u klasičnom pristupom zahtijevalo nekoliko desetina grama materijala.]]></summary_hr><summary_en><![CDATA[Self-organizing systems are key to understanding complex systems and exploring interactions. This project aims to utilize the &#39;&#39;coffee ring&#39;&#39; effect to develop new protocols for evaluating drug candidates in early discovery stages, enhancing research efficiency and cost-effectiveness. The focus is on self-organizing motifs, using inkjet printer technology for precise application of microdroplets. Specialized devices allow the expansion of traditional manual sample preparation from hundreds to thousands of trials per formulation. This enables extensive experiments with minimal material, crucial in phases where material availability is limited. Technological and scientific advances proposed include systematic data analysis, central to the project. Techniques like optical microscopy and scanning electron microscopy (SEM) provide insights into structural and morphological properties. Raman spectroscopy offers chemical characterization at the microscopic level, essential for understanding properties and determining interactions critical in formulation design.Additionally, the project integrates machine learning with microscopic analysis to enhance prediction of pharmaceutical properties and performance. Advanced algorithms can analyze images to detect patterns and features that traditional methods miss, allowing deeper understanding of how physical and chemical properties affect drug behavior and stability.The goal is to develop a platform that enables gaining insights from just a few milligrams of active substance, a quantity that would traditionally require several tens of grams of material. This approach not only streamlines research but also significantly reduces material requirements, fostering more sustainable and innovative pharmaceutical development]]></summary_en></project><project>
<id>17134</id><title_hr><![CDATA[Fasciola hepatica vs. Fascioloides magna: potencijalni utjecaj nezavičajne vrste parazita na bioraznolikost]]></title_hr><title_en><![CDATA[Fasciola hepatica vs. Fascioloides magna: potential impact of allochthonous parasite on biodiversity]]></title_en><user_id>3919</user_id><user_firstLast_name>Dean Konjević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2024-05</proposal_call><code>IP-2024-05-8056</code><acronim><![CDATA[HEPiMAG]]></acronim><duration>16.12.2024 - 15.12.2027</duration><status>U tijeku</status><financ_value>193.745,50 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Veterinarska medicina, Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Veterinary medicine, Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Veterinarski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Veterinary Medicine]]></institution_en><team_members_id>868646, 577, 20442, 868660, 868629, 868634, 868617, 5928, 868284, 4742, 12919, 868631, 17766, 872954, </team_members_id><team_members_names><![CDATA[Jovan Mirčeta, Snježana Lubura Strunjak, Zdravko Janicki, Magdalena Palić, Ana Šikić, Tomislav Jelić, Matija Jandrilović, Krešimir Krapinec, Nikolina Škvorc, Krešimir Severin, Lucija Šerić Jelaska, Dejan Bugarski, Miljenko Bujanić, SHAB NOOR, ]]></team_members_names><keywords_hr><![CDATA[Fasciola hepatica, Fascioloides magna, međuodnos, posrednik, bioraznolikost,sučelje divlje-domaće životinje]]></keywords_hr><keywords_en><![CDATA[Fasciola hepatica, Fascioloides magna, interaction, intermediate host, biodiversity, wildlife-livestock interface]]></keywords_en><summary_hr><![CDATA[Nezavičajne vrste parazita mogu predstavljati prijetnju naivnim populacijama životinja. Metiljavost životinja u Europi uzrokovana je zavičajnim jetrenim i buražnim metiljima, te nezavičajnim metiljem Fascioloides magna.  Kako oba metilja imaju jednaki razvojni ciklus, postavlja se pitanje njihove kompeticije na nivou posrednika. Negativne interakcije variraju od suprimiranja pa čak do ubijanja druge vrste. Istraživanja u svijetu navode nedostatak podataka o ovom dijelu, posebice u slučaju F. hepatica i F. magna. Pretpostavka istraživanja je da uslijed međusobne kompeticije na razini posrednika i eventualno nositelja F. hepatica danas uglavnom održava ruralni ciklus u domaćih životinja, dok je F. magna prisutan uglavnom u silvatičnom ciklusu. Ciljevi projekta: utvrditi prevalenciju oba metilja u domaćih i divljih životinja; utvrditi korištenje sučelja divlje-domaće životinje u odnosu na prisutnost metilja; istražiti odnos razvojnih stadija u posredniku; mapirati i analizirati rizik invazije na promatranim područjima te utvrditi učinak nezavičajne vrste na metilja F. hepatica. Analizirat će se zajedničko korištenja pašnih površina pregledom terena i fotozamkama, te invadiranost pregledom jetara i izmeta. Puževi će se pregledati na prisutnost razvojnih stadija metilja, koji će se identificirati morfološkim i molekularnim metodama. U pokusnom dijelu uzgajat će se puževi u tri terarija te će prva skupina biti invadirana miracidijima metilja F. hepatica, druga skupina miracidijima F. magna i treća skupina miracidijima obje vrste. Morfološkim, histološkim i molekularnim metodama pratit će se razvoj i međusobni odnos metilja, te identificirati metacerkarije. Po prvi puta će se utvrditi međusobni odnos ove dvije vrste na razini posrednika te učinak nezavičajne vrste metilja na bioraznolikost. Steći podaci prevalenciji ovih metilja u različitim nositeljima i ulozi sučelja divlje-domaće životinje u prijenosu i održavanju uzročnika.    ]]></summary_hr><summary_en><![CDATA[Non-native parasite species can pose a threat to naive animal populations. In Europe, trematodosis is caused by the native liver and rumen flukes, and the non-native fluke Fascioloides magna. As both flukes have the same developmental cycle, the question of their competition at the level of intermediate host arises. Negative interactions range from suppression to killing of other species. Studies indicate a lack of data in this field, especially in the case of F. hepatica and F. magna. The hypothesis is that due to competition at the level of intermediate and final hosts, F. hepatica mainly uses rural cycle in livestock, while F. magna uses mainly the sylvatic cycle. The goals are: to determine the prevalence of both flukes in domestic and wild animals; determine the wildlife-livestock interface with respect to flukes; to investigate interactions between the fluke&#39;s developmental stages in the snails; to map and analyze the risk of infection and to determine the impact of the F. magna on the F. hepatica. Joint use of grazing areas will be analyzed by observations and photo traps, while infection will be analyzed by liver and feces analysis. Snails will be examined for the presence of fluke developmental stages, identified by morphological and molecular methods. In the experimental part, snails will be grown in three terraria; the first group will be infected by the F. hepatica miracidia, the second by the F. magna miracidia, and the third by the miracidia of both species. Morphological, histological and molecular methods will be used to monitor development and interaction of flukes, and to identify metacercariae. Mutual relationship between these two species at the level of intermediate host and the effect of the non-native fluke on biodiversity  will be determined for the first time. Data on the prevalence of these flukes in different hosts and the role of the wildlife-livestock interface in the transmission and maintenance of the causative agent will be obtained.]]></summary_en></project><project>
<id>17142</id><title_hr><![CDATA[Između reupotrebe i inovacije: razumijevanje mikroregionalnih strategija naseljavanja u kasnoj antici na istočnom Jadranu]]></title_hr><title_en><![CDATA[Between reuse and innovation: understanding microregional settlement strategies in late antiquity on the eastern Adriatic ]]></title_en><user_id>3216</user_id><user_firstLast_name>Ana Konestra</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2024-05</proposal_call><code>IP-2024-05-6792</code><acronim><![CDATA[Re:Set]]></acronim><duration>16.12.2024 - 15.12.2027</duration><status>U tijeku</status><financ_value>185.850,00 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Arheologija, </scie_field_hr><scie_field_en>Archeology, </scie_field_en><institution_hr><![CDATA[Institut za arheologiju]]></institution_hr><institution_en><![CDATA[Institute of Archaeology in Zagreb]]></institution_en><team_members_id>22964, 29528, 868159, 868475, 3860, 3064, 868076, 868080, 868124, 865169, </team_members_id><team_members_names><![CDATA[Fabian  Welc, Kamil Rabiega, Paula Androić Gračanin, Anita Dugonjić, Toni  Brajković, Goranka Lipovac Vrkljan, Agnese Kukela, Bartosz Nowacki, Malgorzata Zaremba, Natali Neral, ]]></team_members_names><keywords_hr><![CDATA[Kasna antika, istočni Jadran, utvrđenja, ruralna naselja, urbana naselja ]]></keywords_hr><keywords_en><![CDATA[Late Antiquity, eastern Adriatic, fortifications, rural settlements, urban settlements]]></keywords_en><summary_hr><![CDATA[Kasna antika, u najširem poimanju, razdoblje je značajnih političkih, ekonomskih, fiskalnih i okolišnih promjena. Iako se o njima još raspravlja, nedvojbeno su uzrokovale opću nestabilnost, zbog koje su, kao odgovor i strategija rješavanja, uvedene manje i veće inovacije, koje su dovele do značajnih društvenih, vjerskih i kulturnih transformacija. Ti se procesi reflektiraju u krajoliku kroz nekoliko globalno prepoznatih, snažno regionaliziranih, a ponekad i kontrastnih pojava, poput promjena u postojećim urbanim i ruralnim naseljima, pojava novih, često utvrđenih lokaliteta, te novonastala teritorijalna organizacija. Načini i vremenski okviri u kojima je istočni Jadran sudjelovao u tomu valu preobrazbi još uvijek su nedovoljno razjašnjeni kako u detaljima tako i u društvenim implikacijama. Za razumijevanje društvenih odgovora zajednica istočnog Jadrana na višestruke izazove kasnoantičkih globalnih i specifičnih regionalnih procesa potrebno je prikupiti i analizirati različite nove podatke na mikroregionalnoj razini. Kroz interdisciplinarna arheološka istraživanja usmjerena na detaljno dokumentiranje stratigrafskih sekvenci, prikupljanje novih i raznovrsnih podataka, njihovu analizu i precizno datiranje, ovim će se istraživanjem identificirati inovacije i transformacije u naseljavanju u ruralnom i urbanom kontekstu, na dvama različitim područjima rimske Dalmacije: sjeverne Liburnija (Kvarner, Sjeverno Hrvatsko primorje) i središnjeg obalnog dijela istočnoga Jadrana. Odabrane studije slučaja (otok Rab i Danilo – rimski Rider) omogućit će usporedbu lokaliteta s različitim razvojnim putanjama, okolišnim i krajobraznim značajkama te time upotpuniti dosadašnje spoznaje o odnosu između urbanih, ruralnih i utvrđenih lokaliteta kasnoantičke Dalmacije, stvarajući nove podatke potrebne za uključivanje istočnoga Jadrana u šire rasprave o kasnoj antici.]]></summary_hr><summary_en><![CDATA[The broadly understood late antique period was one of significant political, economic, fiscal, and environmental changes. Though still debated, they led to a general instability, in response to which, large- and small-scale innovations were introduced as coping strategies, bringing about extensive social, religious, and cultural transformations. These processes are reflected in the landscape through several globally recognised, strongly regionalised, and often contrasting phenomena, such as changes in existing urban and rural settlements, the emergence of new, often fortified sites, and newly formed territorial organisation. The ways and timeframes in which the eastern Adriatic participated in this wave of transformations and shifting are still poorly understood in the nuances of their occurrence and their social implications. Therefore, understanding societal responses of eastern Adriatic communities to the manyfold challenges posed by late antique global and more regional processes needs to be reassessed by collecting and analysing diverse new datasets at a microregional level. Through interdisciplinary archaeological research aimed at detailed documenting of stratigraphic sequences and collecting new and varied data that will be comprehensively analysed and well dated, this research will set out to recognise innovations and transformations in settling in both rural and urban contexts, within two different areas of Roman Dalmatia: northern Liburnia (Kvarner, Northern Croatian littoral) and the central coastal part of the eastern Adriatic. The selected case studies (the island of Rab and Danilo – Roman Rider) will allow us to compare sites with different development trajectories, environmental and landscape features, and fill in the gaps in current knowledge on the relationship between urban, rural, and fortified sites of late antique Dalmatia, collecting new data necessary to include the eastern Adriatic into wider discussions on late antiquity. ]]></summary_en></project><project>
<id>17147</id><title_hr><![CDATA[Kognitivne pristranosti kao izvor suboptimalnih odluka u turizmu i problema (ne)održivosti: Razumijevanjem pristranosti do kvalitetnijeg upravljanja turizmom]]></title_hr><title_en><![CDATA[Cognitive biases as a source of suboptimal decisions in tourism and (un)sustainability problems: Understanding biases for better management of tourism]]></title_en><user_id>5218</user_id><user_firstLast_name>Ivan Sever</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2024-05</proposal_call><code>IP-2024-05-1450</code><acronim><![CDATA[BIASTOUR]]></acronim><duration>16.12.2024 - 15.12.2027</duration><status>U tijeku</status><financ_value>81.000,00 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, Psihologija, </scie_field_hr><scie_field_en>Economy, Psychology, </scie_field_en><institution_hr><![CDATA[Institut za turizam]]></institution_hr><institution_en><![CDATA[Institute for Tourism in Zagreb]]></institution_en><team_members_id>868520, 13295, 17736, 7092, 26102, 872951, </team_members_id><team_members_names><![CDATA[Ana Perišić, Velibor Mačkić, Vedran Recher, Jelena Mušanović, Dominik-Borna Ćepulić, Julia Biloš, ]]></team_members_names><keywords_hr><![CDATA[održivost turizma, bihevioralna ekonomija, kognitivne pristranosti, nadoknada ugljika, prekomjerni turizam, eksperiment odabira]]></keywords_hr><keywords_en><![CDATA[tourism sustainability, behavioural economics, cognitive biases, carbon offsets, overtourism, choice experiment]]></keywords_en><summary_hr><![CDATA[Predloženi projekt zasniva se na principima bihevioralne ekonomije, koji će se primijeniti u proučavanju kognitivnih pristranosti u percepciji i odlukama turista i lokalnog stanovništva, a koje su povezane s aspektima okolišne i društvene održivosti turizma. Bolje shvaćanje kognitivnih pristranosti i mehanizama donošenja odluka predstavlja značajan potencijal za povećanje učinkovitosti mjera i politika održivog razvoja turizma. U projektu će se sistematski ispitati potencijal afektivnih komponenti stavova u promicanju pro-okolišnog ponašanja, na primjeru usvajanja dobrovoljnih programa za nadoknadu ugljika. Također će se analizirati postojanje kognitivnih pristranosti u razmatranju takvih programa te preferencije turista prema obilježjima programa nadoknade ugljika. Kognitivne pristranosti prisutne su i u drugim aspektima turističkog iskustva, a u projektu će se analizirati kognitivne pristranosti koje potencijalno mogu objasniti zanemarivu važnost subjektivne ili objektivne razine korištenja zaštićenog prirodnog područja i zadovoljstva posjetitelja. Definirat će se metodološke smjernice za ublažavanja rizika iskrivljenog vrednovanja usluga ekosustava što će omogućiti stvaranje kvalitetnije informacijske osnovice za planove upravljanja zaštićenim prirodnim područjima. Hrvatske destinacije u sve većoj mjeri se suočavaju s problemima prekomjernog turizma, što ne samo da predstavlja rizike po okoliš, već stvara i rizike po dobrobit lokalnog stanovništva. Postojeća istraživanja su utvrdila kako postoji visoki rizik niza kognitivnih pristranosti prilikom donošenja odluke o potpori turizmu, a koje bi trebalo detaljnije istražiti. Stvaranjem metodološkog okvira za bolje razumijevanje (i)racionalnosti odluke o podršci turističkom razvoju, ovim projektom će se omogućiti formiranje politika turističkog razvoja kojima se dugoročno promiče dobrobit lokalnog stanovništva.]]></summary_hr><summary_en><![CDATA[This project is based on the principles of behavioural economics, which will be applied in the study of cognitive biases in the perception and decisions of tourists and local residents, in the context of environmental and social sustainability of tourism. A better understanding of cognitive biases and decision-making mechanisms represents untapped potential for increasing the effectiveness of measures and policies that support sustainable tourism development. During this project we will systematically examine the potential of affective components of attitude in promoting pro-environmental behaviour, i.e., voluntary carbon offsetting. We will also study the existence of cognitive biases in the consideration of voluntary carbon offsets and the preferences of tourists towards the attributes of carbon offsetting programs. Cognitive biases also exist in other aspects of tourism experience, and in this project we will analyse cognitive biases that can potentially explain the negligible importance of the subjective or objective use level of the protected natural area on visitor satisfaction. Methodological guidelines will be defined to mitigate the risk of distorted valuation of ecosystem services, which will enable the creation of a better information basis for managing protected natural areas. Croatian destinations are increasingly facing the problems of overtourism, which not only poses risks for the environment, but also creates risks for the well-being of the local population. Existing research indicates that there is a high risk of a number of cognitive biases when making a decision on supporting tourism, which should be investigated in more detail. By creating a methodological framework that enables a better understanding of the (ir)rationality in the residents&#39; decisions to support tourism development, this project will support the formation of tourism development policies that promote the long-term well-being of the local population.]]></summary_en></project><project>
<id>17156</id><title_hr><![CDATA[Konačnoelementni modeli za analizu stabilnosti tankostjenih kompozitnih grednih konstrukcija]]></title_hr><title_en><![CDATA[Finite element models for stability analysis of thin-walled composite beam-type structures]]></title_en><user_id>3309</user_id><user_firstLast_name>Goran Turkalj</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2024-05</proposal_call><code>IP-2024-05-6868</code><acronim><![CDATA[STACOBEAM]]></acronim><duration>16.12.2024 - 15.12.2027</duration><status>U tijeku</status><financ_value>99.600,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Temeljne tehničke znanosti, Strojarstvo, </scie_field_hr><scie_field_en>Basic engineering sciences, Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Tehnički fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Engineering]]></institution_en><team_members_id>13121, 3329, 17760, 23703, 872940, </team_members_id><team_members_names><![CDATA[Goranka Štimac Rončević, Domagoj Lanc, Damjan Banić, Sandra Kvaternik, Raul Ivan Gašljević, ]]></team_members_names><keywords_hr><![CDATA[kompozitne gredne konstrukcije, analiza stabilnosti, tankostjeni poprečni presjek, laminatni kompoziti, FG kompoziti, gredni konačni element]]></keywords_hr><keywords_en><![CDATA[composite beam-type structures, stability analysis, thin-walled cross-section, laminate composites, FG composites, beam finite element]]></keywords_en><summary_hr><![CDATA[Projekt će se baviti razvojem numerički model za analizu stabilnosti tankostjenih grednih i okvirnih konstrukcija sastavljenih od nebalansiranih i nesimetričnih laminatnih kompozita te FG (functionally graded) kompozita u režimima promjenjive temperature i vlažnosti. Numerički algoritmi temeljit će se na prostornom tankostjenom grednom konačnom element s 14 stupnjeva slobode gibanja. Kao mjera za opisivanje deformacije koristit će se Green-Lagrangeova tenzor deformacije, dobiven na temelju nelinearnog polja pomaka kompozitnog tankostjenog poprečnog presjeka koje uključuje efekte velikih prostornih rotacija i vitoperenja. Za dobivanje ravnotežnih jednadžbi prostornog grednog konačnog elementa bit će primijenjen princip virtualnih radova i updated Lagrangian inkrementalna deskripcija. Kod nelinearne analize stabilnosti koristiti će se inkrementalno-iterativne procedure rješavanja nelinearnog sustava algebarskih jednadžbi. Za provođenje force recovery procedure koristit će se transformacijska matrica temeljena na polutangencijalnim rotacijama, koje su energijski konjugirane s polutangencijalnim momentima i imaju svojstvo komutativnosti.]]></summary_hr><summary_en><![CDATA[The project will deal with the development of a numerical model for stability analyzing of thin-walled beam and frame structures composed of unbalanced and asymmetrical laminate composites, and of FG (functionally graded) composites under regimes of variable temperature and moisture. Numerical algorithms will be based on a spatial thin-walled beam finite element with 14 degrees of freedom of motion. As a strain measure, the Green-Lagrange strain tensor will be used, obtained on the basis of the nonlinear displacement field of the composite thin-walled cross-section, which includes the effects of large spatial rotations an warping. To obtain the equilibrium equations of the spatial beam finite element, the principle of virtual works and the updated Lagrangian incremental description will be applied. In the nonlinear stability analysis, incremental-iterative procedures for solving the nonlinear system of algebraic equations will be used. To perform the force recovery procedure, a transformation matrix based on semi-tangential rotations will be used, which are energetically conjugated with semi-tangential moments and have the property of commutativity.]]></summary_en></project><project>
<id>17161</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Adwait Anand Parchure]]></title_hr><title_en><![CDATA[]]></title_en><user_id>865076</user_id><user_firstLast_name>Adwait Anand Parchure</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-4513</code><acronim><![CDATA[]]></acronim><duration>20.12.2024 - 07.03.2025</duration><status>U tijeku</status><financ_value>6.630,00 eur</financ_value><scie_area_hr>Interdisciplinarno područje znanosti</scie_area_hr><scie_area_en>Interdisciplinary scientific area</scie_area_en><scie_field_hr>Biotehnologija u biomedicini, </scie_field_hr><scie_field_en>Biotechnology in Biomedicine, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Fakultet biotehnologije i razvoja lijekova]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Biotechnology and Drug Development]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Glavni cilj ovog istraživanja je unaprijediti trenutno razumijevanje imunološkog odgovora tijekom infekcije virusom na sljedeću razinu. Identificirali smo ključni put odgovora urođenog imuniteta, poznat kao PKR-posredovan prekid translacije, u odgovoru na infekciju herpes simplex virusom 1 (HSV-1) u ljudskim staničnim linijama. Ovo otkriće otvara mogućnost dizajniranja novih antivirusnih lijekova. Međutim, kako bismo to postigli, ključno je provjeriti valjanost naših nalaza u kompatibilnom modelnom organizmu. Kroz ovu planiranu obuku, cilj nam je istražiti odgovaraju li stanice, koje potječu od miševa, na infekciju HSV-1 na sličan način kao ljudske stanice u laboratoriju. Korištenje stanica izravno dobivenih od životinja omogućava nam procjenu izvedivosti miševa kao modelnog organizma za daljnji preklinički razvoj novih lijekova. Nadalje, s obzirom na utjecaj blisko povezanih herpesvirusa na globalno zdravlje, namjeravamo istražiti učinke identificiranog puta na ostale članove obitelji herpesvirusa.Organizacija-domaćin: Leibniz institut za virologiju, Njemačka]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>17163</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Lia Vidas]]></title_hr><title_en><![CDATA[]]></title_en><user_id>864947</user_id><user_firstLast_name>Lia Vidas</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-4295</code><acronim><![CDATA[]]></acronim><duration>14.03.2025 - 30.05.2025</duration><status>U tijeku</status><financ_value>6.630,00 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Arheologija, </scie_field_hr><scie_field_en>Archeology, </scie_field_en><institution_hr><![CDATA[Institut za antropologiju]]></institution_hr><institution_en><![CDATA[Institute for Anthropological Research]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Doktorsko istraživanje asistentice Vidas bavi se rekonstrukcijom obrazaca ponašanja lovačko-skupljačkih zajednica na prostoru Istre u vremenu kasnog pleistocena na temelju analize osteološkog faunskog materijala. Navedeno se nastoji ostvariti prvenstveno primjenom nove analitičke metode zooarheologije masenom spektrometrijom (ZooMS). Radi se o biomolekularnoj metodi kojom se, nakon izolacije kolagena iz koštanog fragmenta i mjerenja masa peptide u masenom spektrometru, dolazi do determinacije na taksonomskoj razini. Navedeni pristup potrebno je nadopuniti i rezultatima morfoloških analiza navedenog materijala te je upravo usavršavanje u tom aspektu analize primarni cilj ove mobilnosti. Asistentica će tijekom usavršavanja na Sveučilištu u Tübingenu i kroz rad s dr. Britt Starkovich steći znanja o identifikaciji anatomskog elementa, jedinice, vrste, spola i dobi uz korištenje komparativnih kolekcija. Provest će se i detaljna determinacija tafonomskih promjena antropogenog podrijetla koje su prisutne na uzorcima na kojima je provedena ZooMS analiza. Također, u paleoproteomskom laboratoriju institucije domaćina upoznat će se s njihovim načinom izolacije kolagena i pripreme uzorka za masenu spektrometriju. Usporedba i paralelno provođenje oba aspekta analiza omogućit će joj potpunije shvaćanje različitih obrazaca pribavljanja životinjskih resursa u razdoblju paleolitika. Sva stečena znanja biti će primijenjena u njenom trenutnom i budućem radu na faunskim skupovima, a samostalnost u radu biti će povod novim znanstvenim suradnjama i razvoju novih projektnih prijedloga.Organizacija-domaćin: Eberhard-Karls-Universität Tübingen, Njemačka]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>17169</id><title_hr><![CDATA[Nosiva tehnologija i objašnjiva umjetna inteligencija  u promociji mentalnog zdravlja i inkluzivnosti u školama]]></title_hr><title_en><![CDATA[Wearable Technology and EXplainable AI for Mental Health and Inclusivity in Schools]]></title_en><user_id>1126</user_id><user_firstLast_name>Maroje Sorić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MAPS</proposal_type><proposal_call>2024</proposal_call><code>MAPS-2024-8755</code><acronim><![CDATA[EXperiMental]]></acronim><duration>01.07.2025 - 30.06.2029</duration><status>U tijeku</status><financ_value>79.349,52 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Kineziologija, </scie_field_hr><scie_field_en>Kinesiology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Kineziološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Kinesiology]]></institution_en><team_members_id>861742, 13301, 13488, 874036, 12537, </team_members_id><team_members_names><![CDATA[Antonio Martinko, Hrvoje Podnar, Renata Barić, Jelena Gerjević, Sanja Šalaj, ]]></team_members_names><keywords_hr><![CDATA[tjelesne aktivnost, sedentarno ponašanje, spavanje, stigma, adolescenti]]></keywords_hr><keywords_en><![CDATA[physical activity, sedentary behaviour, sleep, stigma, adolescents]]></keywords_en><summary_hr><![CDATA[Mentalno zdravlje ključno je za opću dobrobit, osobito tijekom adolescencije, razdoblja obilježenog brzim promjenama. Umjetna inteligencija (AI) i mobilne senzorske tehnologije nude inovativne pristupe procjeni mentalnog zdravlja i povezanih promjena u ponašanju (npr. spavanje, tjelesna aktivnost i korištenje pametnog telefona). Međutim, iskorištavanje ovih tehnologija za pomoć adolescentima nedovoljno je istraženo i izazovno. EXperiMental će se uhvatiti u koštac s ovim izazovom kombinirajući znanja iz psihologije i kognitivnih znanosti, biomedicinskih i sportskih znanosti, bihevioralnog sensinga i privatnosti te AI i strojnog učenja. Na početku ćemo adolescente uključiti u participativni istraživački proces kako bismo naučili o njihovim stavovima prema mentalnom zdravlju, digitalnim bihevioralnim intervencijama, umjetnoj inteligenciji, etičkim pitanjima i zdravom načinu života. Zatim ćemo provesti longitudinalno istraživanje koje će uključiti adolescenate u dobi 11-14 godina iz Hrvatske i Rumunjske i prikupiti podatke pomoću mobilnih senzorskih uređaja i standardiziranih upitnika o mentalnom zdravlju kako bismo razvili AI modele koji procjenjuju parametre mentalnog zdravlja i pomažu u održavanju ravnoteže mentalnog zdravlja. Također ćemo proučiti kako ponašanja vezana uz kretanje poboljšavaju mentalno zdravlje, istražujući koje vrste tjelesne aktivnosti djeluju na određene pojedince. Dobiveni uvidi omogućit će nam stvaranje personaliziranih poticaja za promicanje mentalnog zdravlja. U posljednjoj ćemo fazi, zajedno s mladima i učiteljima, kreirati školsku intervenciju koja će sadržavati obrazovne scenarije koji integriraju mentalno zdravlje u školske programe, promiču inkluzivnost i razbijaju stigmu. Uključit ćemo 2 škole u nerandomizirano kontrolirano ispitivanje i isporučiti intervenciju kroz inkluzivne timove i školski kurikul, uz dodatak personalizirane komponente koja se isporučuje kroz naše prilagođene objašnjive AI modele.]]></summary_hr><summary_en><![CDATA[Mental health is crucial for overall well-being, especially during early adolescence, a period marked by rapid changes, making young individuals more susceptible to mental health issues. Artificial intelligence (AI) and mobile sensing technologies offer innovative approaches to estimating mental health and related behavioral changes related (e.g., sleep, physical activity, and smartphone usage). However, utilizing these technologies to aid early adolescents is relatively underexplored and challenging. EXperiMental will tackle this challenge by combining expertise from psychology and cognitive sciences, biomedical and sports science mobile and behavioral sensing and privacy and XAI and machine learning. At the beginning, we will engage adolescents in a participatory research process to learn about their attitudes towards mental health, digital behavioral interventions, AI, data sharing, ethical issues, and lifestyle. Next, we will perform a longitudinal study involving  (11-14-old adolescents  from Croatia and Romania and collect data using mobile sensing devices and standardised mental health questionnaires to develop AI models that estimate mental health parameters and help sustain a mental health equilibrium for everyone. We will also investigate how movement behaviours enhance mental health, exploring what types of PA work for specific individuals. The insights gained will allow us to create personalized nudges to encourage beneficial behaviors and promote mental well-being. In the last phase, we will co-create a school-based intervention with youth and teachers that will contain educational scenarios that integrate mental health literacy into school curricula, promote inclusivity and break stigma. We will engage 2 schools in a non-randomised controlled trial and deliver the intervention through inclusivity teams and Physical Education curriculum, supplemented with a personalised component delivered through our bespoke explainable AI models.]]></summary_en></project><project>
<id>17172</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Ivana Sirovica]]></title_hr><title_en><![CDATA[]]></title_en><user_id>868739</user_id><user_firstLast_name>Ivana Sirovica</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-4847</code><acronim><![CDATA[]]></acronim><duration>14.10.2024 - 13.11.2024</duration><status>U tijeku</status><financ_value>2.635,00 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Šumarstvo, </scie_field_hr><scie_field_en>Forestry, </scie_field_en><institution_hr><![CDATA[Hrvatski šumarski institut]]></institution_hr><institution_en><![CDATA[Croatian Forest Research Institute]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Ivana Sirovica sudjelovat će na znanstveno-istraživačkom usavršavanju upotrebe suvremenih statističkih analiza i modeliranja podataka na Istraživačkom centru Slovenske akademije znanosti i umjetnosti (Slovenija) kod profesora prof. Andraža Čarnija. Znanstveno-istraživačko usavršavanje bit će podijeljeno u 3 faze:Prva faza će uključivati testiranje i odabir adekvatnih metoda u interpretaciji vlastitih podataka s ciljem opredjeljenja šumskih fitocenoza područja Strogog rezervata Bijele i Samarske stijene u sklopu komparativne analize vegetacijskih tipova šireg područja Dinarida. Prilikom istraživanja koristit će se znanstveno uvriježene metode i specijalizirani software-i, jednako kao i javno dostupne baze podataka iz kojih će biti preuzeti pojedini klimatski podaci.Druga faza će uključivati analiziranje značajki pojedinih šumskih fitocenoza na istraživanom području koje uključuju florni sastav, dijagnostičke vrste, strukturu, ekološke uvjete njihovog pridolaska, funkcionalne značajke i biogeografsku pripadnost. Podaci o strukturi, ekološkim uvjetima, funkcionalnosti te biogeografskoj izvornosti svake pojedine biljne vrste biti će objedinjeni u tabličnom prikazu i time poslužiti kao temelj daljnjim analizama. Uz korištenje većeg broja znanstveno uvriježenih metoda i specijaliziranih software-a, pojedini podaci (strategije biljnih vrsta), biti će preuzeti iz javno dostupne baze podataka.Treća faza će uključivati analiziranje mjerenih geomorfoloških (nadmorska visina, ekspozicija, nagib) i pedoloških značajki (pH vrijednost, ukupni dušik, ukupni ugljik, P2O5, K20, organska tvar, CaCO3) utvrđenih šumskih fitocenoza. Prikaz stanja i njihova međusobna usporedba bit će realizirani znanstveno uvriježenim metodama i specijaliziranim software-ima. Također, ovdje će biti određen i najznačajniji mjereni ekološki parametar od najvećeg utjecaja na oblikovanje šumskih fitocenoza. U konačnici, u ovoj fazi započet će se i s planiranjem buduće forme rada temeljem dobivenih rezultata.Organizacija-domaćin: Znanstveno-istraživački centar Slovenske akademije znanosti i umjetnosti (ZRC SAZU), Slovenija]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>17177</id><title_hr><![CDATA[Premošćivanje teorije i eksperimenata: Pomicanje granica precizne fizike oscilacije neutrina]]></title_hr><title_en><![CDATA[Bridging Theory and Experiments: Pushing the Boundaries of Neutrino Oscillation Precision Physics]]></title_en><user_id>867422</user_id><user_firstLast_name>Manojit Ghosh</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MAPS</proposal_type><proposal_call>2024</proposal_call><code>MAPS-2024-9120</code><acronim><![CDATA[NuTex]]></acronim><duration>01.07.2025 - 30.06.2029</duration><status>U tijeku</status><financ_value>61.449,66 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>867190, 835, 867971, </team_members_id><team_members_names><![CDATA[Leon Halić, Budimir Kliček, Doris Barčot, ]]></team_members_names><keywords_hr><![CDATA[Fizika neutrina, oscilacije neutrina, akceleratorski neutrini, modeli okusa za masu i miješanje neutrina, udarni presjek neutrina]]></keywords_hr><keywords_en><![CDATA[Neutrino Physics, Neutrino oscillation, Accelerator neutrinos, Flavour models for neutrino mass and mixing,  Neutrino cross-section]]></keywords_en><summary_hr><![CDATA[Ovaj projekt udružuje eksperimentaliste i fenomenologe s komplementarnim stručnim znanjem iz Švicarske (CH), Poljske (PL) i Hrvatske (HR) koji pokrivaju kritična istraživačka područja u fizici neutrina. Glavni zadaci su:A. Proučavanje fenomenologije oscilacije neutrina s T2K, ESSnuSB i drugim eksperimentima. Analizirat ćemo eksperimentalne i simulirane podatke kako bismo razumjeli nove fizičke učinke, kao i neka neslaganja među sadašnjim neutrinskim eksperimentima. Konkretno, pokušat ćemo istražiti preferiraju li podaci T2K eksperimenta neku novu fiziku izvan standardnog scenarija s tri okusa i pokušati predložiti rješenje za postojeću napetost između T2K i NO$\nu$A podataka. Također, bavit ćemo se fenomenološkim učincima za postojeće i predložene modele mase i miješanja neutrina, testirajući ih za različite eksperimentalne udaljenosti. Također ćemo pokušati razumjeti može li se novi fizički scenarij zabuniti s trenutnim sistematskim neodređenostima te može li buduće poboljšanje ovih neodređenosti riješiti navedeni problem. B. Postavljanje posebne aktivnosti među grupama ESSnuSB, NINJA i T2K za mjerenja udarnog presjeka.Ovi eksperimenti su osjetljivi u području ispod GeV, gdje trenutačno nema mjerenja udarnog presjeka. Trenutno, NINJA mjeri udarni presjek na T2K energijama, tj. 0,6 GeV. Koristit ćemo ove podatke za poboljšanje modela udarnih presjeka vezanih za T2K. Nadalje, postavljanje NINJA detektora u prizemlju postrojenja J-PARC omogućit će nam mjerenje udarnog presjeka pri ESSnuSB energijama, tj. 0,4 GeV. U ovom projektu ideja je staviti mali prototip NINJA detektora u prizemlje J-PARC postrojenja kako bi se razumjela relevantna pozadina i izvršila potrebna simulacija za postavljanje kompletnog detektora. Ove informacije o udarnom presjeku ćemo prevesti u poboljšanje sistematskih neodređenosti koje će se dalje koristiti u analizi oscilacija.]]></summary_hr><summary_en><![CDATA[This project joins experimentalists and phenomenologists with complementary expertise from Switzerland (CH), Poland (PL) and Croatia (HR) covering critical research areas in neutrino physics. The main tasks to be undertaken are:A. Study of neutrino oscillation phenomenology with T2K, ESSnuSB and other experiments. We will analyse experimental and simulated data to understand new physics effects as well as some of the tensions among present neutrino experiments. In particular, we will try to explore if T2K data prefers any new physics beyond the standard three flavour scenario and try to propose a solution to the current tension between T2K and NO$\nu$A data. We will also work on phenomenological effects for existing and proposed  neutrino mass and mixing models, testing them for various neutrino experimental oscillation baselines. We will also try to understand if a new physics scenario can be confused with the current systematic uncertainties and if the future improvement in the systematic error can resolve this problem. B. Setting up a special activity among ESSnuSB, NINJA and T2K groups for cross-section measurements.    These experiments are sensitive in the sub-GeV region, where at present there is no measurement on the cross-section. Currently NINJA is measuring cross-section at the T2K energies i.e., 0.6 GeV. We will use this data to improve the cross-section models related to T2K experiment. Furthermore, placing the NINJA detector at the ground floor in the J-PARC facility will enable us to measure the cross-section at the ESSnuSB energies i.e., 0.4 GeV. In this project the idea is to put a small prototype NINJA detector in the J-PARC facility ground floor to understand the relevant background and perform the required simulation for the full detector setup. These cross-section information will be translated into improved systematic errors which will be used in the oscillation analysis.  ]]></summary_en></project><project>
<id>17178</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Iva Šunić]]></title_hr><title_en><![CDATA[]]></title_en><user_id>861518</user_id><user_firstLast_name>Iva Šunić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-2627</code><acronim><![CDATA[]]></acronim><duration>01.11.2024 - 14.02.2025</duration><status>U tijeku</status><financ_value>9.010,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut za antropologiju]]></institution_hr><institution_en><![CDATA[Institute for Anthropological Research]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Mikrobiom, koji uključuje sve mikroorganizme prisutne u našem okruženju, može imati značajan utjecaj na zdravlje, kako pozitivno tako i negativno. S obzirom na to da provodimo veliki dio vremena u zatvorenim prostorima, uključujući spavanje, povećava se naša izloženost mikroorganizmima iz okoline, posebno onima iz kreveta. Sastav mikrobioma kućne prašine može povezati okolišne utjecaje s mikrobiomom koji kolonizira dišne puteve djece, što izravno utječe na njihov imunološki sustav. Respiratorne bolesti su česte kod male djece zbog nedovoljno razvijenog imunološkog sustava. Izloženost mikrobiomu u ranoj dobi ključna je za pravilan razvoj imunološkog sustava. U okviru istraživanja, analizirat će se kako prisutnost ili odsutnost određenih mikroorganizama utječe na zdravlje dišnog sustava. Također će se istražiti ključni okolišni čimbenici, poput prisutnosti kućnih ljubimaca i demografskih karakteristika domaćinstva, koji mogu utjecati na mikrobiom unutarnjeg prostora i zdravlje dišnog sustava djece. Navedeni istraživački rad planira se realizirati u suradnji sa Sveučilištem u Kopenhagenu, poznatom po svom istraživačkom fokusu na mikrobiom i njegovo djelovanje na zdravlje. Ovo istraživanje će doprinijeti boljem razumijevanju interakcija između mikrobioma, okolišnih čimbenika i razvoja respiratornih bolesti kod djece.Organizacija-domaćin: University of Copenhagen, Danska]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>17185</id><title_hr><![CDATA[Postati aksolotl: Empatija, simulacija i oličenje u srednjovjekovnim narativima]]></title_hr><title_en><![CDATA[Becoming Axolotl: Empathy, Simulation, and Embodiment in Medieval Narratives]]></title_en><user_id>6488</user_id><user_firstLast_name>Mirko Sardelić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MAPS</proposal_type><proposal_call>2024</proposal_call><code>MAPS-2024-7736</code><acronim><![CDATA[Medieval Simulations]]></acronim><duration>01.07.2025 - 30.06.2029</duration><status>U tijeku</status><financ_value>49.513,21 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Interdisciplinarne humanističke znanosti, Filozofija, Povijest, Etnologija i antropologija, </scie_field_hr><scie_field_en>Interdisciplinary humanities, Philosophy, History, Ethnology and anthropology, </scie_field_en><institution_hr><![CDATA[Hrvatska akademija znanosti i umjetnosti]]></institution_hr><institution_en><![CDATA[Croatian Academy of Sciences and Arts]]></institution_en><team_members_id>868743, 23272, 868749, 26237, 868748, 868680, </team_members_id><team_members_names><![CDATA[Giovanni Tarantino, Martino Rossi Monti, Keith Holyoak, Valentina Šoštarić, Pia Campeggiani, Maja Perić, ]]></team_members_names><keywords_hr><![CDATA[srednjovjekovni narativi, kognitivna simulacija, afekt, senzorna percepcija, empatija]]></keywords_hr><keywords_en><![CDATA[medieval narratives, cognitive simulation, affect, sensorial perception, empathy]]></keywords_en><summary_hr><![CDATA[Empatija i čitanje misli su ključne sastavnice i svakodnevnih društvenih interakcija i našeg uranjanja u fiktivne svjetove raznih žanrova. No, brojni se srednjovjekovni tekstovi usredotočuju na empatiju usmjerenu prema neočekivanim pravcima, tražeći od publike da simuliraju kognitivna, emotivna i senzorna iskustva radikalnih Drugih koji obuhvaćaju neljudske agente - i one koji osjećaju i one koji ne osjećaju (poput životinja, biljaka i predmeta) - natprirodnih entiteta (poput bogova ili duhova) i rasno obilježenih ljudskih bića (koja su u većini srednjovjekovnih literarnih i umjetničkih djela konstruirana kao ne baš ljudska). U ovom projektu analizirat će se (u širokom komparativnom istraživanju) europski srednjovjekovni tekstovi koji su pozivali svoju publiku da se stave u kožu ovih marginaliziranih entiteta, psihički, senzorno i afektivno. Nastavljajući se na recentna istraživanja u kognitivnim književnim studijima, naratologiji i kritičkoj teoriji (napose okolišna humanistika, predmetno orijentirana ontologija i kritička teorija rase), ovaj projekt nastoji uspostaviti novi metodološki okvir na neistraženim (ili zanemarenim) križanjima istraživačkih polja tako što će se posvetiti raznim kulturnim prostorima i točkama dodira s radikalnim Drugima diljem i izvan srednjovjekovne Europe, od 8. do 15. stoljeća, od Islanda do Anatolije (no sežući zapadno i do Sjeverne Amerike a istočno do Središnje Azije). Izvori koje će proučavati i analizirati bit će staroengleske zagonetke, srednjoengleske romance, staronordijske sage, bizantske hagiografije, ali i dosad nikad uspostavljene dvostruke perspektive euroazijskih kontakata (arapski i mongolski doživljaj Europljana - uz već poznate obrnute). Projekt će rezultirati potpuno novim interpretacijama kognitivno-kulturnih okvira koje su srednjovjekovni ljudi uspostavljali i kroz njih simulirali misli, osjećaje i senzacije najrazličitijih Drugih, poput mačeva, stabala, medvjeda, duhova, mongolskih kanova i europskih križara.]]></summary_hr><summary_en><![CDATA[Empathy and mind-reading are essential to both everyday social interactions and to our immersion in fictional worlds across media genres. Yet many medieval texts focus empathy in unexpected directions, asking their audiences to simulate the cognitive, emotional, and sensorial experience of radical others, which encompass non-human agents, both sentient and non-sentient (animals, plants, objects) supernatural entities (spirits, gods), and racialized humans (constructed as not-quite-human in much of medieval literature and art). This project is a broadly comparative investigation of medieval European texts that invited their audiences to inhabit the perspective of these de-centred entities, mentally, sensorially, and affectively. Building on recent work in cognitive literary studies, narratology, and critical theory (especially environmental humanities, object-oriented ontology, and critical race theory), this project aims to create a new methodological framework at the underexplored intersection of these fields of inquiry whereby it will cast spotlights on a variety of cultural spaces and points of encounter with radical others across and beyond medieval Europe, from the eighth to the fifteenth century, from Iceland to Anatolia (but extending westward to North America and eastward to Central Asia). Its sources include Old English riddles, Middle English romances, Old Norse sagas, Byzantine hagiographies, and a hitherto unattempted double perspective of Eurasian contacts (Arabic and Mongolian accounts of Europeans and vice versa). The project will result in a ground-breaking account of the cognitive-cultural frameworks that medieval people used to engage with and imaginatively simulate the thoughts, feelings, and sensations of a variety of others including swords, trees, bears, spirits, Mongolian khans, and European crusaders.]]></summary_en></project><project>
<id>17188</id><title_hr><![CDATA[Sigurnosna procjena vjetroagregata u slučaju udara munja]]></title_hr><title_en><![CDATA[Wind turbine lightning safety evaluation ]]></title_en><user_id>5633</user_id><user_firstLast_name>Božidar Filipović-Grčić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MAPS</proposal_type><proposal_call>2024</proposal_call><code>MAPS-2024-4500</code><acronim><![CDATA[WISE]]></acronim><duration>01.07.2025 - 30.06.2029</duration><status>U tijeku</status><financ_value>77.149,89 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, Kemijsko inženjerstvo, Računarstvo, Temeljne tehničke znanosti, Interdisciplinarne tehničke znanosti, </scie_field_hr><scie_field_en>Electrical engineering, Chemical engineering, Computer sciences, Basic engineering sciences, Interdisciplinary technological sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>23336, 866625, 17798, 6159, 865063, </team_members_id><team_members_names><![CDATA[Nina Stipetić, Antonio Šunjerga, Marina Ptiček, Bojan Franc, Franjo Vuković, ]]></team_members_names><keywords_hr><![CDATA[Munje, Zaštita, Vjetroagregati, Eksperimentalno, Mjerenje, Norme, Kompozitni materijali]]></keywords_hr><keywords_en><![CDATA[Lightning, Protection, Wind Turbines, Experimental, Measurement, Standards, Composites]]></keywords_en><summary_hr><![CDATA[Ovaj projekt istražuje adekvatnost postojećih normi za zaštitu vjetroagregata od udara munja. To je opravdano činjenicom da je većina zahtjeva za naknadu šteta povezanih s proizvodnjom energije vjetra uzrokovana udarima munja. Postojeće preporuke za zaštitu od munje temelje se na statistici parametara munje dobivenih iz udara u visoke tornjeve. Primijećeno je da je fizikalni proces udara munje u vjetroagregat značajno drugačiji u usporedbi s udarom u visoki toranj. Važne razlike postoje u smislu struje koja se injektira, mehanizma prihvata ili materijala objekta u koji udara munja. Nekoliko visokih tornjeva diljem svijeta opremljeno je mjernom opremom kako bi se prikupila statistika o parametrima munja, što se obično radi istovremenim mjerenjem struje munje i odgovarajućih elektromagnetskih polja, snimanjem brzim kamerama, mjerenje emitiranog rendgenskog zračenja, itd. Suprotno tome, sustavna promatranja udara munje u vjetroagregate su mnogo rjeđa.Opći cilj projekta je pružiti nove preporuke tijelima za standardizaciju kako bi se bolje zaštitili vjetroparkovi od munje. Da bi se postigao ovaj konačni cilj, tijekom projekta će se ostvariti sljedeći specifični ciljevi:- Uspostaviti suvremeni opservatorij za promatranje udara munje vjetroagregate u Hrvatskoj kako bi se dobili pouzdani statistički podaci o uzlaznim udarima munja na vjetroagregatima.- Bolje razumjeti mehanizme razvoja uzlaznih munja iz vjetroagregata i razlike u odnosu na statične visoke objekte.- Procijeniti utjecaj struje uzlaznog udara munje na kompozitne materijale i razviti otpornije materijale.Rezultati projekta doprinijet će poboljšanju zaštite vjetroparkova, koji su i dalje ranjivi na ovaj prirodni fenomen. Razumijevanje fizikalnog procesa uzlaznog udara munje na vjetroagregatima može pomoći u dizajniranju poboljšanih mjera zaštite i preciznom predviđanju razine opasnosti na bilo kojoj lokaciji.]]></summary_hr><summary_en><![CDATA[This project investigates the adequacy of existing wind turbine lightning protection standards. This is justified by the fact that majority of the insurance claims related to wind generation are caused by lightning strikes. The existing lightning protection recommendations are established upon statistics of lightning parameters obtained from strikes to tall towers. It has been observed that the physics associated to lightning striking a wind turbine is significantly different to the one characterizing a tall-tower strike. Important differences exist in terms of the current injected, the attachment mechanism or the material of the striking object. Several tall towers are instrumented worldwide to feed the statistics about the lightning discharge, typically done by means of simultaneous measurements of lightning currents and the corresponding electromagnetic fields, hi-speed video imaging, X-ray radiation, ... On the contrary, much less common is the systematic observation of wind-turbine lightning.The general objective of the project is to provide new recommendations to the standardization bodies to better protect wind farms against lightning.To achieve this final goal, the project aims to realize the following specific objectives:- Realize a state-of-the-art wind-turbine lightning observatory in Croatia to obtain reliable statistical data on upward lightning to wind turbines.- Better understand the mechanisms of the initiation of upward flashes from wind turbines and the differences with respect to static tall structures.- Evaluate the impact of upward lightning current on composite materials and develop more resilient ones.The outcomes of the project will be of great help to improve the protection of wind parks, still vulnerable against this natural phenomenon. Understanding how lighting initiates from wind turbines and the underlying physics can aid in designing improved protection measures and predicting incident levels accurately at any given location.]]></summary_en></project><project>
<id>17189</id><title_hr><![CDATA[Sekunde su važne: napredni sustav ranog upozoravanja o potresu]]></title_hr><title_en><![CDATA[Seconds Matter: Cutting-edge Earthquake Early Warning Systems]]></title_en><user_id>208</user_id><user_firstLast_name>Iva Dasović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MAPS</proposal_type><proposal_call>2024</proposal_call><code>MAPS-2024-4655</code><acronim><![CDATA[Seconds Matter]]></acronim><duration>01.07.2025 - 30.06.2029</duration><status>U tijeku</status><financ_value>80.179,74 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Geofizika, </scie_field_hr><scie_field_en>Geophysics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>26662, 26762, 37, 12922, 870784, </team_members_id><team_members_names><![CDATA[Marija Mustać Brčić, Marin Sečanj, Marijan Herak, Krešimir Kuk, Katarina Zailac, ]]></team_members_names><keywords_hr><![CDATA[Rano upozoravanje na potres, strojno učenje, distribuirana optička mjerenja, Vrancea, Dinaridi]]></keywords_hr><keywords_en><![CDATA[earthquake early warning, machine learning, distributed acoustic sensing, Vrancea, Dinarides]]></keywords_en><summary_hr><![CDATA[Rano upozoravanje na potres (EEW) može ublažiti potresom uzrokovane gubitke najavljujući primateljima nadolazeću trešnju nekoliko sekundi unaprijed. U funkciji je u mnogim zemljama, ali nijedna država u Europi ne upravlja javnim EEW sustavom (EEWS). Nedavno je SED-ETHZ postavio EEWS s aplikacijom za mobilni telefon u Srednjoj Americi. Naš je cilj primijeniti i unaprijediti ovaj sustav u RO, HR i CH, gdje je seizmički hazard umjeren do visok. U RO je EEWS uveden prije dva desetljeća, s fokusom na duža vremena upozorenja za Bukurešt – 150 km od jakih potresa u Vrancei. Državna seizmološka mreža sad uključuje postaje prikladne za EEWS s javnim masovnim upozorenjima kratkog vremenskog odziva. U HR su potresi iz 2020. godine rezultirali velikim ulaganjem u seizmološku mrežu, koja će ubrzo postati prikladna za EEWS, ali ne i u EEWS. SED u CH već desetljeće upravlja EEWS-om za internu upotrebu i igra važnu ulogu u razvoju EEW-a.Nedavno su strojno učenje (ML) i distribuirana optička mjerenja (DAS) počeli mijenjati seizmologiju: ML za automatiziranu obradu podataka, a optička su vlakna (DAS) su senzori visoke prostorne i vremenske rezolucije. Još nisu primijenjeni u EEWS.U našem četverogodišnjem projektu primijenit ćemo, upravljati i poboljšati (polu)javni EEWS s konvencionalnim algoritmima u RO, HR i CH: prilagoditi ih složenoj regionalnoj seizmičnosti (duboki vs. plitki potresi), poboljšati procjenu gibanja tla koristeći sintetičke seizmograme i integrirati ML algoritme za analiziranje seizmograma i predviđanje trešnje. Paralelno ćemo istražiti kako unaprijediti EEWS integracijom DAS podataka i ML-a, razviti novi pristup koji će zaobići tradicionalno određivanje/procjenu parametara izvora i usredotočiti se izravno na predviđanje gibanja tla te koristiti nove ML-om generirane sintetičke seizmograme za optimizaciju metode za rijetke ekstremne i složene nizove potresa. Osim toga, istražit ćemo društveni aspekt EEW kako bismo što bolje komunicirali i isporučili EEW.]]></summary_hr><summary_en><![CDATA[Earthquake Early Warning (EEW) can mitigate earthquake losses by warning recipients seconds before the impending shaking. It is in operation in many countries, but no country in Europe operates a public EEW system (EEWS). Recently, the SED-ETHZ has set up an EEWS in Central America with a mobile phone app. Our goal is to replicate and expand this system in RO, HR and CH, where the seismic hazard is moderate to high.In RO, the EEWS was introduced two decades ago, with a focus on longer warning times for Bucharest – 150 km from the major earthquakes in Vrancea. The national seismic network now includes EEW-capable stations required for an EEWS with low-latency public mass warnings. In HR, a series of earthquakes in 2020 led to major investment in the seismic network, soon to become EEW-capable, but not in an EEWS. In CH, the SED has been operating a non-public EEWS for internal use for a decade and plays an important role in EEW development.Recently, machine learning (ML) and Distributed Acoustic Sensing (DAS) started to transform seismology: ML improves automated data processing, and optical fibres (DAS) are sensors with high spatial and temporal resolution. They still need to be implemented in EEWS.In our four-year project, we will set up, operate and improve a (semi-)public EEWS with conventional algorithms in RO, HR and CH: adapt for complex regional seismicity (deep vs. shallow events), improve the ground motion estimation using synthetic waveforms and integrate ML algorithms for picking and shaking prediction. In parallel, we will investigate how to upgrade the EEWS by integrating DAS data and ML, develop a new EEW approach to bypass traditional source parameter detection and estimation and focuses directly on ground motion prediction, and use new ML-generated synthetic seismograms to optimise the method for rare extreme events and complex sequences. In addition, we will explore the social aspect to understand how EEW can be best communicated and deliver.]]></summary_en></project><project>
<id>17193</id><title_hr><![CDATA[Posljedice onečišćenja nano/mikroplastikom na zdravlje vodenog okoliša]]></title_hr><title_en><![CDATA[Implications of Nano/Microplastic Pollution on AquatiC Environment HealTh]]></title_en><user_id>124</user_id><user_firstLast_name>Branko Glamuzina</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MAPS</proposal_type><proposal_call>2024</proposal_call><code>MAPS-2024-3501</code><acronim><![CDATA[IMPACT]]></acronim><duration>01.07.2025 - 30.06.2029</duration><status>U tijeku</status><financ_value>79.517,49 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, Fizika, Kemija, </scie_field_hr><scie_field_en>Biology, Physics, Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Dubrovniku]]></institution_hr><institution_en><![CDATA[University of Dubrovnik]]></institution_en><team_members_id>4605, 1518, 1513, 2789, 2862, 26388, 26037, 26153, </team_members_id><team_members_names><![CDATA[Marijana Pećarević, Tatjana Dobroslavić, Vlasta Bartulović, Sanja Tomsic, Ana Bratoš Cetinić, Marina  Brailo Šćepanović, Kruno Bonačić, Sanja Grđan, ]]></team_members_names><keywords_hr><![CDATA[nano/mikroplastika, morski okoliš, bezkralježnjaci, lanci prehrane, ljudsko zdravlje]]></keywords_hr><keywords_en><![CDATA[nano/microplastics, marine environment, invertebrates, food webs, human health]]></keywords_en><summary_hr><![CDATA[ Učinci prirodno stare plastike u makro, mikro i nanorazmjerima na vodene mikro i makro organizme proučavat će se po prvi put u integriranom, multidisciplinarnom pristupu koji obuhvaća toksičnost za okoliš, fizikalno-kemijske aspekte, biologiju i akvakulturu kako bi se sveobuhvatno razumjele molekularne promjene povezane s unosom, praćenjem i ekološkim učincima duž trofičkih lanaca, kao i utjecaj na ljudsku prehranu. Provedba projekta dovest će do napretka u analitici, ekotoksikologiji i biologiji mora. Projekt će se provoditi u Malostonskom zaljevu (Hrvatska), važnom području za uzgoj školjkaša na istočnoj jadranskoj obali, a fokusirat će se na istraživanje trenutačnih razina nano- i mikroplastike u morskoj vodi te u uzgojenim školjkašima, plosnatoj kamenici (Ostrea edulis) ) i  dagnje (Mytilus galloprovincialis) kao i u još dva jestiva lokalna organizma, bodljikavom volku (Hexaplex trunculus) i morskom ježincu (Paracentrous lividus). Na temelju istraživanja prirodnih voda provest će se daljnji laboratorijski eksperimenti kako bi se istražili učinci realnih i literaturno utemeljenih koncentracija nano- i mikroplastike na vrste i hranidbene mreže. Stari plavi polipropilen, kojeg ima u izobilju u slatkovodnim i morskim ekosustavima, koristit će se za kalibrirano usitnjavanje kako bi se odredile čestice mikro i nano veličine i distribucija vlakana za kontroliranu izloženost mikroalgama, zooplanktonu i morskim bezkralježnjacima kako bi se kvantitativno procijenio unos plastike i molekularne promjene povezane s unosom nano/mikroplastike.]]></summary_hr><summary_en><![CDATA[The effects of macro-, micro- and nanoscale naturally aged plastics on aquatic micro- and macro-organisms will be studied for the first time in an integrated, multidisciplinary approach encompassing environmental toxicity, physico-chemical aspects, biology and aquaculture to comprehensively understand the molecular changes associated with uptake, tracking and ecological effects along trophic chains, as well as the impact on human nutrition. The implementation of the project will lead to advances in analytics, ecotoxicology and marine biology. The project will be carried out in Malostonski Bay (Croatia), an important shellfish farming area on the eastern Adriatic coast, and will focus on researching the current levels of nano- and microplastics in seawater and in farmed shellfish, the flat oyster (Ostrea edulis) and the Mediterranean mussel (Mytilus galloprovincialis) as well as in two other edible local organisms, the murex snail (Hexaplex trunculus) and the sea urchin (Paracentrous lividus). Based on a study of natural waters, further laboratory experiments will be conducted to investigate the effects of realistic and literature-based concentrations of nano- and microplastics on species and food webs. Aged blue polypropylene, reportedly abundant in freshwater and marine ecosystems, will be used for calibrated pulverisation to determine micro- and nano-sized particles and distribution of fibres for controlled exposure to microalgae, zooplankton and seafood to quantitatively assess plastic uptake, molecular changes associated with nano/microplastic uptake.]]></summary_en></project><project>
<id>17195</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Bartul Vuksan-Ćusa]]></title_hr><title_en><![CDATA[]]></title_en><user_id>868744</user_id><user_firstLast_name>Bartul Vuksan-Ćusa</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-3502</code><acronim><![CDATA[]]></acronim><duration>14.10.2024 - 19.12.2024</duration><status>U tijeku</status><financ_value>5.695,00 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Politologija, </scie_field_hr><scie_field_en>Political Science, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet političkih znanosti]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Political Science]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Asistent Bartul Vuksan-Ćusa će ovim znanstveno-istraživačkim usavršavanjem unaprijediti znanja i vještine potrebne za daljnji razvoj doktorskog istraživanja koje se provodi na Autonomnom sveučilištu u Barceloni. Ta znanja i vještine se ponajprije odnose na kvazi-eksperimentalnu i eksperimentalnu metodologiju u empirijskim politološkim istraživanjima, a koja se u ovom slučaju primjenjuju u svrhu istraživanja fenomena populizma na individualnoj razini. Doktorsko istraživanje je prvo takvog tipa u Hrvatskoj i svrha mu je analizirati konstrukciju populističkih stavova, testirati različite načine mjerenja takvih stavova i mehanizme njihove aktivacije. Konkretnije rečeno, znanstveno-istraživački boravak na Sveučilištu u Radboudu ima za svrhu produkciju dvaju radova. Prvi rad koristi metodu prirodnog eksperimenta u stvarnom okruženju te nastoji odgovoriti na pitanje utječu li politički skandali na jačanje populističkih stavova i povećanje namjere glasanja za populiste. Drugi rad eksperimentalno provjerava utječe li izbor riječi u anketnim upitnicima na rezultate mjerenja populizma i ovisi li to o drugim političkim stavovima i biračkim preferencijama ispitanika. Obzirom na to da je populizam osporavan koncept, ali i poštapalica i označitelj koji se svakodnevno koristi u medijskom i političkom diskursu, ovaj rad nastoji testirati analitičku korisnost i funkcionalnost njegovog mjerenja na individualnoj razini te time doprinijeti širem, komparativnom razumijevanju koncepta.Organizacija-domaćin: Radboud Universiteit, Nizozemska]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>17198</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Tamara Rom]]></title_hr><title_en><![CDATA[]]></title_en><user_id>866746</user_id><user_firstLast_name>Tamara Rom</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-9579</code><acronim><![CDATA[]]></acronim><duration>09.10.2024 - 22.12.2024</duration><status>U tijeku</status><financ_value>6.375,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Science]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Zvijezde poput Sunca i divovski planeti poput Jupitera formiraju se na različite načine. Zvijezde nastaju kolapsom jezgri u molekularnim oblacima, dok se divovski planeti formiraju u diskovima oko mladih zvijezda putem fragmentacije ili akumulacije materijala na jezgru. No, između ovih klasa objekata nalaze se smeđi patuljci - subzvjezdani objekti koji su masivniji od planeta, ali nedovoljno masivni za izgaranje vodika u svojim središtima, što je primarni uvjet da bi se objekt mogao nazvati zvijezdom. Njihovo postojanje ukazuje na to da granica između formiranja zvijezda i planeta nije tako jasno definirana kako se nekoć mislilo, što naglašava složenost procesa formiranja u svemiru.Naše istraživanje usmjereno je na Westerlund 1, intenzivno područje stvaranja zvijezda u Miiječnoj stazi, koristeći podatke Svemirskog teleskopa James Webb. Cilj je analizirati populaciju zvijezda male mase i subzvjezdanu populaciju ovog skupa kako bismo procijenili raspodjelu zvjezdanih masa u trenutku nastajanja posebno u tom području. Ovo će biti prvi put da je sadržaj smeđih patuljaka karakteriziran u ovom skupu ili bilo kojem drugom zvjezdanom skupu s intenzivnim stvaranjem zvijezda, pružajući ključan uvid u formaciju subzvjezdanih objekata u ekstremnim okolišima.Identifikacija i karakterizacija subzvjezdane populacije u skupu Westerlund 1 su od ključne važnosti za izvedbu raspodjele mase u ovom specifičnom okruženju. Usporedba s rezultatima drugih skupova, posebno uzimajući u obzir uvjete okoline kao što su UV tokovi i gustoća zvijezda u skupu, omogućavaju nam bolje razumijevanje ovisnosti raspodjele mase o tim čimbenicima. Očekujemo da će rezultati ovog istraživanja pridonijeti dubljem razumijevanju procesa formiranja zvijezda i planeta u različitim galaktičkim okruženjima, te potaknuti daljnji razvoj teorija o nastanku smeđih patuljaka u svemiru.Organizacija-domaćin: Institue of Astrophysics and Space Sciences, University of Lisbon, Portugal]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>17199</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Josipa Lipovac]]></title_hr><title_en><![CDATA[]]></title_en><user_id>865247</user_id><user_firstLast_name>Josipa Lipovac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-2941</code><acronim><![CDATA[]]></acronim><duration>11.11.2024 - 10.04.2025</duration><status>U tijeku</status><financ_value>12.835,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Josipa Lipovac, asistentica i doktorandica na Fakultetu elektrotehnike i računarstva, pri Laboratoriju za bioinformatiku i računalnu biologiju te članica ŠikićLab-a, u sklopu svog doktorskog istraživanja radi na poboljšanju klasifikacije metagenomskih uzoraka dugih očitanja na taksonomskoj razini soja. Pod mentorstvom doc. dr. sc. Krešimira Križanovića radi na razvijanju metode za redukciju velike referentne baze genoma koja bi se prvenstveno koristila u kontekstu uspješnije klasifikacije metagenomskog uzorka na taksonomskoj razini soja. Spomenuta metoda temelji se na de novo sastavljanju metagenoma. Na usavršavanju asistentica će surađivati s dr.sc. Riccardom Vicedominijem i njegovim GenScale laboratorijem s IRISA instituta u Rennesu. Pripadnici spomenutog laboratorija te mentor-domaćin iskusni su znanstvenici u području de novo sastavljanja metagenoma na taksonomskoj razini soja te će pomoći asistentici na usavršavanju njezinog istraživanja koje će očekivano biti objavljeno u koautorstvu s njima na nekoj od međunarodnih bioinformatičkih konferencija ili u nekom od vodećih međunarodnih bioinformatičkih časopisa.Organizacija-domaćin: Institute for Research in Computer Science and Random Systems (IRISA), Francuska]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>17204</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Tvrtko Karlo Kovačević]]></title_hr><title_en><![CDATA[]]></title_en><user_id>865267</user_id><user_firstLast_name>Tvrtko Karlo Kovačević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-5028</code><acronim><![CDATA[]]></acronim><duration>04.11.2024 - 06.05.2025</duration><status>U tijeku</status><financ_value>15.640,00 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Prehrambena tehnologija, </scie_field_hr><scie_field_en>Food technology, </scie_field_en><institution_hr><![CDATA[Institut za poljoprivredu i turizam]]></institution_hr><institution_en><![CDATA[Institute of Agriculture and Tourism in Poreč]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[U posljednje vrijeme, znanstvena istraživanja su usredotočena na analizu promjena u biljkama koje proizlaze iz nepovoljnih okolišnih uvjeta poput nedostatka vode i povišene temperature zraka. Modeli za prognoziranje klimatskih promjena za mediteranski pojas Europe upućuju na dulje i ozbiljnije periode suše te više temperature zraka u bliskoj budućnosti, čime će biti zahvaćena i Hrvatska. Nedostatak vode i visoke temperature predstavljaju značajne oblike nepovoljnih okolišnih uvjeta koji mogu negativno utjecati na prinos svih usjeva, uključujući i češnjaka.Kao odgovor na nepovoljne uvjete, biljke su razvile kompleksne mehanizme za ublažavanje učinaka, poput sinteze i akumulacije specifičnih molekula kao što su aminokiseline, šećeri, vitamini i brojne druge. Sinteza i akumulacija specifičnih molekula potencijalno može dovesti do razvoja proizvoda s poboljšanom nutritivnom vrijednosti. Istraživanje, razumijevanje i unaprjeđenje otpornosti biljaka na biokemijskoj razini prema nedostatku vode i povišenoj temperaturi, uzrokovanih klimatskim promjenama, posebno na jugu Europe, ključno je za održivu praksu u primarnoj proizvodnji hrane.Provođenjem sveobuhvatne analize metabolizma češnjaka, odnosno neciljane analize te upotrebom bioloških baza podataka, poput Kyoto Encyclopedia of Genes and Genomes (KEGG), identificirat će se svi mjerljivi produkti metabolizma češnjaka, ali i druge biokemijske nepoznanice. Osim navedenog, rezultati neciljane analize pružit će širu sliku utjecaja nedostatka vode i povišene temperature na razine i međuodnos produkata metabolizma i njihovih pripadajućih metaboličkih puteva tj. pružit će uvid u otpornost biljke češnjaka na nepovoljne okolišne uvjete.Asistentov odlazak na predloženo znanstveno-istraživačko usavršavanje značajno bi pridonijelo identifikaciji ključnih biokemijskih procesa, molekula i metaboličkih puteva koji pridonose sposobnosti biljke češnjaka da se prilagodi i izdrži nepovoljne okoline uvjete, što bi posljedično doprinijelo razvoju strategije održive primarne proizvodnje hrane u kontekstu klimatskih promjena. Osim navedenog, asistentov odlazak na predloženo znanstveno-istraživačko usavršavanje značajno bi pomogao pri izradi kvalitetnijeg doktorskog rada i budućih znanstvenih radova, a usvojena znanja i vještine bi mu omogućile daljnju specijalizaciju u takvim vrstama analize.Organizacija-domaćin: Fondazione Edmund Mach, Italija]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>17209</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Silvestar Grabušić]]></title_hr><title_en><![CDATA[]]></title_en><user_id>868314</user_id><user_firstLast_name>Silvestar Grabušić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-3949</code><acronim><![CDATA[]]></acronim><duration>02.12.2024 - 09.01.2025</duration><status>U tijeku</status><financ_value>3.315,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Tehnologija prometa i transport, </scie_field_hr><scie_field_en>Transport technology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet prometnih znanosti]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Transport and Traffic Sciences]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Na razini Europske unije, prometne nesreće uzrokovane nepropisnim prelaskom preko željezničke pruge i rizičnim ponašanjem na željezničko-cestovnim prijelazima čine značajan udio ukupnog broja prometnih nesreća u željezničkom prometu. Tijekom mobilnosti, doktorand će se usmjeriti na prikupljanje, obradu i analizu dostupnih podataka o prethodno navedenim prometnim nesrećama. Doktorand planira koristiti podatke prikupljene iz više država i različitih lokacija kako bi identificirao moguće razlike u čimbenicima koji utječu na nepropisne prijelaze preko željezničke pruge u Hrvatskoj i svijetu. Ovi podaci omogućiti će dublje razumijevanje specifičnih uzroka nesreća u različitim kontekstima i pružiti temelje za prijedlog preventivnih mjera.Organizacija-domaćin: Sapienza Universita di Roma, Italija]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>17213</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Marin Ivanković Ivanković]]></title_hr><title_en><![CDATA[]]></title_en><user_id>865421</user_id><user_firstLast_name>Marin Ivanković Ivanković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-8796</code><acronim><![CDATA[]]></acronim><duration>17.03.2025 - 16.09.2025</duration><status>U tijeku</status><financ_value>15.640,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, </scie_field_hr><scie_field_en>Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Vjetroturbine su ključni uređaji za proizvodnju energije iz obnovljivih izvora. Kako bi se povećala njihova učinkovitost i dugovječnost, potrebno je poboljšati aerodinamičke značajke lopatica vjetroturbina. Predloženi istraživački projekt je usmjeren na korištenje pasivnih uređaja za kontrolu strujanja, i to generatora vrtloga i Gurney zakrilca, kako bi se poboljšale aerodinamičke značajke vjetroturbina u različitim uvjetima rada.Glavni cilj istraživanja je određivanje optimalne konfiguracije generatora vrtloga i Gurney zakrilca s ciljem poboljšanja aerodinamičkih značajki lopatica vjetroturbina. Ispitat će se učinkovitost generatora vrtloga i Gurney zakrilca u statičkim i dinamičkim uvjetima, uključujući rotaciju lopatica, kako bi se osigurala primjenjivost rezultata u stvarnim uvjetima rada vjetroturbina. Istraživanje će se provesti kroz niz eksperimenata u zračnom tunelu. Ispitat će se različite konfiguracije generatora vrtloga i Gurney zakrilca na modelu aeroprofila koji predstavlja dio lopatice vjetroturbine. Najbolje konfiguracije će se ispitati i na modelu male vjetroturbine s horizontalnom osi rotacije (BeRT) kako bi se istražio učinak generatora vrtloga i Gurney zakrilca u rotirajućem okruženju. Koristit će se napredne tehnike mjerenja, poput PIV (Particle Image Velocimetry), kako bi se dobio uvid u značajke strujanja oko lopatica vjetroturbine.Očekuje se da će rezultati istraživanja polučiti značajno poboljšanje učinkovitosti vjetroturbina, uključujući povećanje koeficijenta uzgona, smanjenje koeficijenta otpora i smanjenje histerezne petlie u uvjetima dinamičkog sloma uzgona. Dobiveni rezultati također će pomoći u razvoju naprednih računalnih modela koji se mogu koristiti za daljnje optimiranje vjetroturbina. Rezultati ovog istraživanja će značajno doprinijeti razvoju vjetroturbina, što će povećati proizvodnju čiste energije i smanjiti ovisnost o fosilnim gorivima. Poboljšana učinkovitost vjetroturbina također će dovesti do smanjenja troškova proizvodnje energije iz vjetra, što je ključan korak prema održivoj budućnosti.Rezultati istraživanja će biti objavljeni u vodećim znanstvenim časopisima i predstavljeni na međunarodnim konferencijama. Predloženo istraživanje će unaprijediti tehnologiju vietroturbina, čineći ih efikasnijima i ekonomičnijima. Time će se pridonijeti globalnim naporima za povećanje udjela obnovljivih izvora energije u ukupnoj proizvodnji električne energije, što je ključno za borbu protiv klimatskih promjena i zaštitu okoliša.Organizacija-domaćin: Technische Universität Berlin, Institute of Fluid Dynamcis and Technical Acoustics, Njemačka]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>17215</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Jelena Strišković]]></title_hr><title_en><![CDATA[]]></title_en><user_id>26590</user_id><user_firstLast_name>Jelena Strišković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-6246</code><acronim><![CDATA[]]></acronim><duration>15.10.2024 - 14.01.2025</duration><status>U tijeku</status><financ_value>7.820,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Odjel za fiziku]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Department of Physics]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Svi smo učili da se svjetlost u vakuumu kreće konstantnom brzinom i da se ništa u vakuumu ne kreće brže od svjetlosti. Još smo u osnovnoj školi naučili da je ta maksimalna brzina približno 3x10° m/s. Asistentica Jelena Strišković, doktorandica iz područja astročestične fizike u svome radu provjerava je li to uistinu tako.1915. godine Einstein je objavio svoju opću teoriju relativnosti. Koliko god ona bila predivna, ona ne može objasniti što se događa u središtima crnih rupa i na početku Svemira. Kako bi odgovorili na ta pitanja okrenuli smo se području kvantne gravitacije u kojoj želimo povezati kvantnu mehaniku koja upravlja najsitnijim objektima, i gravitaciju koja upravlja najmasivnijim objektima. Neki od najpoznatijih kandidata za teoriju kvantne gravitacije su teorija petlji i teorija struna. Jelenino istraživanje usredotočeno je na eksperimentalnu potragu za kvantnom gravitacijom pomoću gama-zraka vrio visokih energija. One su nastale primjerice pri zvjezdanim eksplozijama te su električni neutralne pa se zbog toga mogu širiti kroz Svemir bez da ih magnetska polja zakreću; time nose ključne informacije o ekstremnim kozmičkim događajima. Neki kandidati za teoriju kvantne gravitacije predviđaju narušenje Lorentzove simetrije. Lorentzova simetrija je povezana primjerice s Einsteinovom pretpostavkom o konstantnosti brzine svjetlosti. U svom istraživanju doktorandica Strišković koristi metodu Time of Flight (ToF) za istraživanje narušenja Lorentzove simetrije. Analizom gama-zraka iz izvora poput blazara BL Lacertae, opaženih teleskopima MAGIC i LST-1 (smještenih na kanarskom otoku La Palma), nastoji otkriti male devijacije koje bi mogle ukazivati na kvantne gravitacijske efekte.Kako bi to ostvarila, Jelena surađuje s vodećim stručnjacima u Parizu kako bi dovršila razvoj koda gLike za kombiniranje podataka iz različitih izvora i instrumenata za identifikaciju mogućih povreda Lorentzove simetrije. lako kvantna gravitacija nema neposrednu praktičnu primjenu, njezino otkriće moglo bi imati revolucionarni utjecaj na znanost i tehnologiju, slično kao otkriće kvantne mehanike. Ovo istraživanje ne samo da produbljuje naše razumijevanje svemira, već također pokazuje važnost interdiscipliname i međunarodne suradnje u postizanju značajnih znanstvenih napredaka.Organizacija-domaćin: Laboratoire de physique nucleaire et des hautes energies, Sorbonne Universite, Francuska]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>17218</id><title_hr><![CDATA[Prilagodba upravljanje šumama za očuvanje biološke raznolikosti u planinskim šumama obične smreke pod utjecajem klimatskih promjena]]></title_hr><title_en><![CDATA[Adapted forest management for biodiversity conservation in mountain Norway spruce forests under climate change]]></title_en><user_id>3754</user_id><user_firstLast_name>Stjepan Mikac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MAPS</proposal_type><proposal_call>2024</proposal_call><code>MAPS-2024-2331</code><acronim><![CDATA[BIOFORMA]]></acronim><duration>01.07.2025 - 30.06.2029</duration><status>U tijeku</status><financ_value>67.363,86 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Šumarstvo, Interdisciplinarne biotehničke znanosti, </scie_field_hr><scie_field_en>Forestry, Interdisciplinary biotechnical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet šumarstva i drvne tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Forestry and Wood Technology]]></institution_en><team_members_id>727, 26804, 866695, 11304, 11184, 22826, 3748, 12394, </team_members_id><team_members_names><![CDATA[Boris Hrašovec, Marko Orešković, Magdalena Brener, Daniel Krstonošić, Željko Škvorc, Domagoj  Trlin, Milivoj Franjevic, Darko Bakšić, ]]></team_members_names><keywords_hr><![CDATA[climate change, forestry, biodiversity, modeling, management]]></keywords_hr><keywords_en><![CDATA[climate change, forestry, biodiversity, modeling, management]]></keywords_en><summary_hr><![CDATA[Planinske šume s dominacijom obične smreke su vrlo osjetljive na promjene okolišnih uvjeta uzrokovane klimatskim promjenama. U alpskoj biogeografskoj regiji Europe ovi šumski ekosustavi imaju veliku ekološku, ekonomsku i kulturnu važnost. Razumijevanje njihovih budućih razvojnih putanja ključno je za održavanje njihove funkcionalnosti i otpornosti. Ciljevi ovog projekta su (1) procijeniti posljedice različitih scenarija upravljanja šumama u kontekstu klimatskih promjena na biološku raznolikost i funkcioniranje ekosustava planinskih šuma obične smreke smreke i (2) pružiti smjernice za dionike o budućim opcijama upravljanja ovim osjetljivim ekosustavima. Kako bismo postigli svoje ciljeve, provest ćemo detaljnu procjenu strukture šuma na 500 ploha u 100 šumskih sastojina, što odražava široku strukturnu raznolikost planinskih šuma smreke i različite sustave upravljanja šumama koji su tradicionalno primijenjeni u Švicarskoj, Hrvatskoj, Bugarskoj i Rumunjskoj (u rasponu od negospodarskih šuma, raznodobog gospodarenja pa sve do čistih sječa). Procijenit ćemo biološku raznolikost ključnih funkcionalnih skupina organizama na ovim plohama, uključujući mikroorganizme tla, vaskularne biljke i mahovine, gljive, insekte i ptice, te ih povezati sa strukturalnim svojstvima šuma. Koristit ćemo modele rasta šuma kako bismo procijenili moguće smjerove razvoja šuma s dominacijom smreke pod različitim scenarijima upravljanja i okolišnim uvjetima, te identificirali najbolje prakse za održavanje biološke raznolikosti, funkcioniranja ekosustava i otpornosti.Osim toga, koristit ćemo podatke daljinskog istraživanja (dronski i zračni LiDAR, daljinska istraživanja) kako bismo podigli vrijednosti biološke raznolikosti na razinu krajolika i uspostavili robusni okvir za praćenje i modeliranje promjena u biološkoj raznolikosti i zdravlju šuma u kontekstu brzih klimatskih promjena. Projekt će također promovirati prijenos znanja i izgradnju kapaciteta u zemljama sudionicama.]]></summary_hr><summary_en><![CDATA[Norway&#39;s spruce-dominated mountain forests are highly sensitive to changing environmental conditions caused by climate change. In the Alpine biogeographic region of Europe, these forest ecosystems hold great ecological, economic, and cultural significance. Understanding their future development trajectories is crucial to maintain their functionality and resilience. This project aims to (1) evaluate the consequences of different forest management scenarios in the context of climate change on biodiversity and ecosystem functioning of spruce-dominated mountain forests and (2) provide guidelines for stakeholders on future forest management options in these sensitive ecosystems. To achieve our goals, we will conduct a detailed assessment of forest structures in 500 plots across 100 forest stands, reflecting the broad structural diversity of mountain spruce forests and the various forest management systems traditionally applied in Switzerland, Croatia, Bulgaria, and Romania (ranging from no management to small-scale irregular shelterwood and clearcut harvesting). We will evaluate the biodiversity of key functional groups of organisms in these plots, including soil microorganisms, vascular plants and mosses, fungi, insects, and birds, and link them to forest structural properties. Using forest growth models, we will assess possible development trajectories of spruce-dominated forests under different management scenarios and environmental conditions, identifying best practices to maintain biodiversity, ecosystem functioning, and resilience.Additionally, we will use remote sensing data (drone- and airborne-based LiDAR, multitemporal satellite data) to upscale biodiversity values to the landscape level and establish a robust framework for monitoring and modeling changes in biodiversity and forest health in the context of rapid climate change. The project will also promote knowledge transfer and capacity building in the participating countries.]]></summary_en></project><project>
<id>17219</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Karlo Jakac]]></title_hr><title_en><![CDATA[]]></title_en><user_id>865250</user_id><user_firstLast_name>Karlo Jakac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-6489</code><acronim><![CDATA[]]></acronim><duration>11.11.2024 - 07.02.2024</duration><status>U tijeku</status><financ_value>7.565,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, </scie_field_hr><scie_field_en>Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Tehnički fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Engineering]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Cilj znanstveno-istraživačkog usavršavanja je razvijanje metode za izračun polja potencijala koristeći fenomen advekcije i meta modela za predviđanje strujanja na površini mora, te integracija te metode u HEDAC algoritam za navođenje bespilotnih letjelica prema ključnim područjima. Time se izbjegava pretraživanje nepotrebnih područja i štedi baterija. Planira se unaprijediti i razviti pristup predviđanja vjerojatnosnog polja čime će se dodatno poboljšati učinkovitost i pouzdanost operacija u stvarnom vremenu.Također, ovo usavršavanje ima potencijal za širu primjenu u okolišnom inženjerstvu, uključujući praćenje i predviđanje širenja onečišćenja, kretanja objekata u vodi i drugih sličnih scenarija. S obzirom na sve veći interes za autonomne sustave i njihovu primjenu u različitim industrijama, rezultati ovog istraživanja mogli bi značajno doprinijeti razvoju naprednih tehnika upravljanja i navigacije bespilotnim letjelicama te otvoriti vrata za daljnje inovacije i suradnje između istraživačkih institucija i industrije.Organizacija-domaćin: Idiap Research Institute, Švicarska]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>17220</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Luka Lanča]]></title_hr><title_en><![CDATA[]]></title_en><user_id>865251</user_id><user_firstLast_name>Luka Lanča</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-1977</code><acronim><![CDATA[]]></acronim><duration>11.11.2024 - 07.02.2025</duration><status>U tijeku</status><financ_value>7.565,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, </scie_field_hr><scie_field_en>Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Tehnički fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Engineering]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Cilj znanstveno-istraživačkog usavršavanja je integracija nestacionarne distribucije mete u HEDAC algoritam za navođenje više bespilotnih letjelica prema ključnim područjima. Time se izbjegava pretraživanje nepotrebnih područja i štedi baterija letjelice, a što je najbitnije, očekuje se bitno povećanje efikasnosti detekcije zbog preciznijeg razmatranja okolišnih uvjeta. Planira se unaprijediti i razviti pristup predviđanja vjerojatnosnog polja, čime će se dodatno poboljšati učinkovitost i pouzdanost operacija u stvarnom vremenu. Također, ovo usavršavanje ima potencijal za širu primjenu u okolišnom inženjerstvu, uključujući praćenje i predviđanje širenja onečišćenja, kretanja objekata u vodi i drugih sličnih scenarija. S obzirom na sve veći interes za autonomne sustave i njihovu primjenu u različitim industrijama, rezultati ovog istraživanja mogli bi značajno doprinijeti razvoju naprednih tehnika upravljanja i navigacije bespilotnim letjelicama te otvoriti vrata za daljnje inovacije i suradnje između istraživačkih institucija i industrije.Organizacija-domaćin: Idiap Research Institute, Švicarska]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>17221</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Nino Kovačić]]></title_hr><title_en><![CDATA[]]></title_en><user_id>868383</user_id><user_firstLast_name>Nino Kovačić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-2879</code><acronim><![CDATA[]]></acronim><duration>01.12.2024 - 01.06.2025</duration><status>U tijeku</status><financ_value>15.555,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Fizika visokih energija naša je osnovna teorija za razumijevanje svemira. Kako bi u laboratoriju reproducirali uvjete kakvi su postojali u ranom svemiru, sudaramo snopove čestica visokih energija. Iz takvih sudara izlijeću čestice koje detektiramo posebnim detektorima u najvećim modernim laboratorijima i na taj način pokušavamo zaključiti što se dogodilo u pojedinom sudaru. Tradicionalne metode analize takvih podataka računalno su zahtjevne i često komprimiraju podatke, time gubeći ključne informacije. Nove računalne metode koje koriste neuralne mreže vrlo su obećavajuće, ali im veliki skupovi podataka mogu predstavljati problem. Helmholtz Attificial Intelligence u Njemačkoj pokrenuo je projekt za razvoj neuralne mreže koja koristi model difuzije, u nadi da će doskočiti tom problemu. Projekt za cilj ima stvoriti set softverskih alata koji koristi suvremene arhitekture neuronskih mreža i tehnika kao što su transformeri, time poboljšavajući mogućnost rada s velikim brojem individualno velikih podataka. U konačnici žele se započeti napori u smjeru stvaranja unificiranog sustava za statističku analizu koja koristi sve raspoložive podatke, što je u žarkom kontrastu s trenutačnim stanjem u znanstvenom krajoliku, gdje svaka grupa i kolaboracija ima vlastiti sistem koji neminovno komprimira podatke. Konačan cilj projekta je osposobiti kandidata da pridonese međunarodnim naporima u razvoju novih metoda zaključivanja u fizici visokih energija, a kroz spomenutu suradnju kandidat bi stekao znanja i vještine koje, zbog svoje novine, jednostavno nisu dostupne u zajednici fizičara u Hrvatskoj, što bi i otvorilo mogućnost diseminaciji tih vještina.Organizacija-domaćin: Deutsches Elektronen Synchrotron (DESY), Njemačka]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>17222</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Vanja Štefanec]]></title_hr><title_en><![CDATA[]]></title_en><user_id>26033</user_id><user_firstLast_name>Vanja Štefanec</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-8012</code><acronim><![CDATA[]]></acronim><duration>02.12.2024 - 02.05.2025</duration><status>U tijeku</status><financ_value>12.920,00 eur</financ_value><scie_area_hr>Interdisciplinarno područje znanosti</scie_area_hr><scie_area_en>Interdisciplinary scientific area</scie_area_en><scie_field_hr>Kognitivne znanosti, </scie_field_hr><scie_field_en>Cognitive Science, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Cilj je ovog znanstveno-istraživačkog usavršavanja upoznati se s metodama analize EEG snimki aktivnosti ljudskoga mozga dok ispitanik sluša jezični podražaj u obliku prirodnog govora na hrvatskom jeziku. Takva analiza zahtijeva izradu, odnosno treniranje, računalnoga prediktivnog modela koji će moći na temelju značajki podražaja, uz određenu prihvatljivu pogrešku, predvidjeti aktivnost mozga koji taj podražaj obrađuje. Analizom računalno naučenih parametara treniranoga prediktivnog modela dobivamo određenu vrstu uvida u to kako ljudski mozak obrađuje jezik te, u konačnici, kako funkcionira ljudska jezična sposobnost.Organizacija-domaćin: Max Planck Institute for Psycholinguistics, Njemačka]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>17227</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Mario Bodružić]]></title_hr><title_en><![CDATA[]]></title_en><user_id>12898</user_id><user_firstLast_name>Mario Bodružić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-2487</code><acronim><![CDATA[]]></acronim><duration>08.11.2024 - 20.12.2024</duration><status>U tijeku</status><financ_value>3.655,00 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Arheologija, </scie_field_hr><scie_field_en>Archeology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zadru]]></institution_hr><institution_en><![CDATA[University of Zadar]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Tijekom usavršavanja na Sveučilistu u Pisi pod mentorstvom dr. Niccola Mazzucca, asistent Mario Bodružić prošrit će postojeće i dograditi novo znanje o analizi tragova uporabe na litičkim nalazima iz gornjepaleolitičkih i mezolitičkih slojeva pećine Vlakno. Usavršavanje će biti fokusirano najviše na rad s mikroskopima visokog uvećanja (do 400X) pod refleksijskim svjetlom, kakvima matična institucija ne raspolaže. Doktorand će također revidirati dosadašnji samostalni rad na materijalu s mentorom i steći nova saznanja i mogućnosti interpretacije rezultata. Analiza tragova uporabe, u domaćoj arheološkoj znanosti do sad je rijetko provođena i to isključivo na materijalu iz mlađeg kamenog doba odnosno neolitika. Ovaj dio disertacije M. Bodružića bit će prva primjena te metode na paleolitičkom i mezolitičkom materijalu sa istočne obale Jadrana.Organizacija-domaćin: Sveučilište u Pisi, Italija]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>17231</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Marina Dubravac]]></title_hr><title_en><![CDATA[]]></title_en><user_id>865198</user_id><user_firstLast_name>Marina Dubravac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-2536</code><acronim><![CDATA[]]></acronim><duration>03.02.2025 - 07.03.2025</duration><status>U tijeku</status><financ_value>2.805,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera Osijek, Fakultet elektrotehnike, računarstva i informacijskih tehnologija Osijek]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Electrical Engineering, Computer Science and Information Technology Osijek]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Europska Unija Održivim strategijama 2030 i 2050 ima za cilj postati klimatski neutralno gospodarstvo s nula emisija štetnih stakleničkih plinova. Sve zemlje članice Europske unije pa tako i Hrvatska razvili su dugoročne nacionalne strategije za plan smanjenja emisija stakleničkih plinova kako bi ispunili svoje obaveze prema Pariškom sporazumu i cilju klimatske neutralnosti Europske unije. Stoga, vlada inicijativama i poticajima se okreće ka većoj integraciji obnovljivih izvora energije na svim razinama. Potrošači koji posjeduju obnovljive izvore energije postaju potrošači s vlastitom proizvodnjom ili aktivni kupci. Osim proizvodnje, potrošači u svome vlasništvu mogu imati električno vozilo koje može služiti kao spremnik viška proizvedene energije. Kao posljedica svega navedenog, mogu se javiti problemi u mreži koji ometaju pouzdan i siguran pogon. Tradicionalni mrežni upravljački mehanizmi mogu imati smanjen učinak prilikom integracije obnovljivih izvora energije, električnih vozila i spremnika energije. Iako mogu uzrokovati probleme u mreži, oni pružaju nove mogućnosti upravljanja i u kombinaciji s postojećim mehanizmima mogu poboljšati prilike u mreži. Znanstveno-istraživačko usavršavanje ima za cilj istražiti i razviti napredne metode i tehnologije koje će omogućiti stabilnu i učinkovitu integraciju obnovljivih izvora energije, električnih vozila i spremnika energije u elektroenergetski sustav. Fokus je prikazati mogućnosti koje se mogu koristiti u aktivnim distribucijskim mrežama i pronalazak optimalnog rješenja za takve mreže. Znanstvenoistraživačko usavršavanje pomoći će pri razmjeni ideja s istraživačima s Organizacije-domaćina i produbljivanje suradnje iz ovoga područja među institucijama. Zaključno, cilj znanstveno-istraživačkog usavršavanja je stvoriti temelje za prijelaz na održiv i klimatski neutralan energetski sustav koji je otporan na izazove budućnosti i prilagodljiv promjenama u potrošnji i proizvodnji energije. Ovaj prijelaz će zahtijevati koordinirane napore svih dionika, uključujući vlade, industriju, akademsku zajednicu i građane, kako bi se osigurala energetska sigurnost, ekonomska učinkovitost i zaštita okoliša za buduće generacije.Organizacija-domaćin: Sveučilište u Ljubljani, Institut za inovacije i razvoj, Slovenija]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>17232</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Katarina Matan]]></title_hr><title_en><![CDATA[]]></title_en><user_id>866716</user_id><user_firstLast_name>Katarina Matan</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-6533</code><acronim><![CDATA[]]></acronim><duration>01.02.2025 - 01.04.2025</duration><status>U tijeku</status><financ_value>5.100,00 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Agronomski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Agriculture]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Pedogeni karbonati su sekundarni karbonatni precipitati koji se formiraju u tlima u sušnim i polusušnim klimama. Njihov nastanak rezultat je otapanja i ponovnog taloženja postojećih geogenih, biogenih ili pedogenih karbonata, te ovisi o mnoštvu čimbenika, no većinom je kontroliran drenažom vode u tlu i koncentracijom CO2. Stvaranje pedogenih karbonata ograničava doprinos CO2 iz tla u atmosferu i posljedično smanjuje globalni atmosferski COz2. Cilj posjeta doktorandice Katarine Matan Sveučilištu u Salamanci (USAL) u Španjolskoj je stjecanje novih saznanja o formaciji pedogenih karbonata, a koja će koristiti pri izradi doktorske disertacije. Tijekom dvomjesečnog boravka na USAL-u biti će analizirani uzorci pedogenih karbonata, te će prethodno prikupljeni podatci o koncentraciji CO2 i sadržaju vlage u tlu biti implementirani u dostupne hidrokemijske modele s ciljem boljeg razumijevanja okolnosti nastanka pedogenih karbonata i brzine njihovog stvaranja.Organizacija-domaćin: Universidad de Salamanca, Španjolska]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>17239</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Lucia Pole]]></title_hr><title_en><![CDATA[]]></title_en><user_id>865066</user_id><user_firstLast_name>Lucia Pole</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-4845</code><acronim><![CDATA[]]></acronim><duration>03.11.2024 - 04.12.2024</duration><status>U tijeku</status><financ_value>2.720,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[U sklopu znanstveno-istraživačkog usavršavanja analizirat će se sastav i rasprostranjenost mikrobnih zajednica te njihova uloga u tlima na području Mediteranske regije Hrvatske. Usvojit će se suvremena metodologija istraživanja mikrobnih zajednica tla uključujući bioinformatičku obradu podataka. Analizirat će se uzorci tla prikupljeni na 7 otoka u sklopu NP Brijuni, na brdu Soline (rt Kamenjak) i u šumi Štinjan kod Pule. Analizom dobivenih rezultata moći će se odrediti relativna brojnost i indeksi biološke raznolikosti mikrobnih zajednica te vidjeti kako sastav mikrobnih zajednica korelira s fizikalno-kemijskim svojstvima tla. Osim toga, na temelju dobivenih podataka, po prvi puta će se analizirati utjecaj veličine otoka i udaljenost od kopna na sastav i rasprostranjenost mikrobnih zajednica u tlu. S obzirom na prikupljanje mnoštva podataka od mikrobnim zajednicama u tlu te fizikalno-kemijskim svojstvima tla, napravit će se prediktivni modeli kojima će se na temelju fizikalno-kemijskih svojstva tla pokušati predvidjeti mikrobne zajednice kao pokazatelji stanja/zdravlja tla, što bi potencijalno moglo smanjiti potrebu za sustavnim monitoringom tla. Organizacija-domaćin: Institut za mikrobiologiju Češke akademije znanosti, Češka Republika]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>17242</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Lu Turković ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>855971</user_id><user_firstLast_name>Lu Turković </user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-3041</code><acronim><![CDATA[]]></acronim><duration>14.10.2024 - 21.01.2025</duration><status>U tijeku</status><financ_value>8.500,00 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Farmacija, </scie_field_hr><scie_field_en>Pharmaceutical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Farmaceutsko-biokemijski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Pharmacy and Biochemistry]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Palbociklib, ribociklib i abemaciklib novi su lijekovi koji se koriste u liječenju hormon-ovisnog raka dojke. U tijeku su istraživanja koja se bave različitostima u njihovoj učinkovitosti i podnošljivosti između pacijenata. Specifičnost je antitumorskih lijekova da previsoka doza može dovesti do značajnih nuspojava, a nedovoljno visoka doza do napretka bolesti. Farmakokinetičko modeliranje predstavlja jedan od temelja boljem upoznavanju uzroka različitosti, kao i pronalasku rješenja, kako bi se terapija prilagodila svakom pojedinom pacijentu postupkom terapijskog praćenja lijekova. Terapijsko praćenje lijekova podrazumijeva određivanje koncentracije lijeka u uzorku pacijenta radi prilagodbe doziranja na temelju specifičnih farmakokinetičkih parametara. Na postizanje ishoda liječenja velik utjecaj ima pridržavanje (adherencija) pacijenta terapiji, pogotovo kod antitumorske terapije, gdje neučinkovita terapija izravno dovodi do napretka bolesti. Procjena adherencije važna je kako bi se dobio uvid u moguće uzroke neučinkovitosti terapije, ali i same uzroke nepridržavanju terapiji na koje je moguće utjecati. Uobičajeno se ispituje razgovorom s liječnikom, pomoću različitih upitnika, uvidom u povijest izdavanja lijeka ili brojanjem primijenjenih doza, međutim niti jedna od ovih metoda nije potpuno pouzdana. Primjenom farmakokinetičkih modela moguće je preciznije odrediti profil adherencije pojedinom lijeku u određenom razdoblju. Cilj predloženog istraživanja je primijeniti farmakokinetičke modele za procjenu adherencije na odabrane lijekove kod uključenih pacijentica. Adherencija antitumorskoj terapiji ključna je za postizanje odgovarajuće učinkovitosti liječenja, dok njen izostanak može biti važan pokazatelj prisutnih terapijskih problema.Organizacija-domaćin: Univerza v Ljubljani, Fakulteta za farmacijo, Slovenija]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>17253</id><title_hr><![CDATA[Dobrobit ravnatelja škola: longitudinalna perspektiva]]></title_hr><title_en><![CDATA[Well-Being of School Principals: A Longitudinal Perspective]]></title_en><user_id>6118</user_id><user_firstLast_name>Irena Burić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MAPS</proposal_type><proposal_call>2024</proposal_call><code>MAPS-2024-7077</code><acronim><![CDATA[WESPA]]></acronim><duration>01.07.2025 - 30.06.2029</duration><status>U tijeku</status><financ_value>72.231,73 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Psihologija, Interdisciplinarne društvene znanosti, </scie_field_hr><scie_field_en>Psychology, Interdisciplinary social sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zadru]]></institution_hr><institution_en><![CDATA[University of Zadar]]></institution_en><team_members_id>6241, 25891, 6601, 874023, 874024, </team_members_id><team_members_names><![CDATA[Izabela Sorić, Mirta Mornar, Maja Parmač Kovačić, Iva Miličević, Petra Đurić, ]]></team_members_names><keywords_hr><![CDATA[ravnatelj škole, dobrobit, zahtjevi posla, resursi, škola, longitudinalna perspektiva]]></keywords_hr><keywords_en><![CDATA[school principal, well-being, job demands, job resources, school, longitudinal research]]></keywords_en><summary_hr><![CDATA[Istraživači su prepoznali važnost profesionalne dobrobiti ravnatelja škola za njihovo radno funkcioniranje i uspješnost škola. Međutim, istraživanja o dobrobiti ravnatelja škola te o njihovim rizičnim (tj. zahtjevima posla) i zaštitnim čimbenicima (tj. osobni i radni resursi) su još uvijek oskudna i fragmentirana, ostavljajući ovo područje nedovoljno razvijenim, posebno u europskom istraživačkom kontekstu. Stoga je cilj ovog međunarodnog projekta produbiti razumijevanje o tome kako ravnatelji škola mogu postići i održati visoke razine dobrobiti, odnosno kako se mogu uspješno nositi sa zahtjevima svojeg posla. Projekt se naslanja na teoriju zahtjeva i resursa posla (JD-R, Bakker i sur., 2023) i teoriju očuvanja resursa (COR, Hobfoll, 1989) te uključuje perspektive ravnatelja i učitelja kao najodgovornijih aktera unutar škola. Preciznije, projektom će se nastojati istražiti:  1) specifične karakteristike posla (tj. zahtjevi i resursi) koje oblikuju dobrobit ravnatelja škola; 2) načini na koje ravnatelji škola mogu unaprijediti i održavati svoje resurse (osobne i radne); 3) postojanje tzv. spirala izgradnje i/ili gubitka resursa kod ravnatelja škola. Sva tri cilja bit će ostvarena analiziranjem međunacionalnih razlika između švicarskih, hrvatskih i rumunjskih ravnatelja škola. Istraživački ciljevi bit će ostvareni u dvije faze. Prvo, provest će se longitudinalno istraživanje u četiri vala koje će uključivati najmanje 220 ravnatelja škola (s pripadajućim učiteljima unutar škola) iz svake zemlje. Drugo, provest će se dnevnička studija u trajanju od 10 radnih dana na uzorku od najmanje 120 ravnatelja škola iz svake zemlje. Dobiveni rezultati bit će diseminirani u vodećim časopisima te znanstvenim skupovima u području te poslužiti kao temelj za kreiranje praktičnih smjernica za unaprjeđenje profesionalne dobrobiti ravnatelja. ]]></summary_hr><summary_en><![CDATA[Scholars have recognized the importance of having healthy and well-functioning school principals for overall school effectiveness. However, research on school principal well-being and its risk (i.e., job demands) and protecting factors (i.e., personal and job resources) is still scarce and fragmented leaving the field underdeveloped, especially in the European research context. Thus, the aim of this project is to understand how school principals can maintain high levels of well-being and how they can successfully handle the demands of their jobs. In exploring a multifaceted concept of school principal well-being, we will use the well-established Job Demands-Resources Theory (JD-R, Bakker et al., 2023) and the Conservation of Resources Theory (COR, Hobfoll, 1989) and collect data from both school principals and teachers to gain insight into perspectives of different responsible actors with the schools. Specifically, the project aims to investigate: 1) specific job characteristics (i.e., demands and resources) that are shaping school principal well-being; 2) how school principals enhance and maintain their resources (personal and job-related); 3) existence of resource caravans (i.e., resource gain and loss cycles) in school principals. All three objectives will be addressed by examining the cross-national differences between Swiss, Croatian, and Romanian school principals. The research objectives will be reached in a two-phase process. In the first phase, we will conduct a four-wave longitudinal study involving at least 220 school principals (and teachers from their schools) from each participating country. In the second phase, we will conduct a 10-days daily diary study on a sample of at least 130 school principals from each participating country. The project results will be disseminated in leading journals in the field and presented at international conferences as well as used to create practical guidelines for improving school principal (and teacher) well-being. ]]></summary_en></project><project>
<id>17256</id><title_hr><![CDATA[Integrirani pristup razumijevanju ugroženosti slatkovodnih školjkaša i njihove otpornosti u uvjetima globalnog zagrijavanja ]]></title_hr><title_en><![CDATA[Multifaceted approach to understand freshwater mussel decline and resilience in the face of global warming]]></title_en><user_id>12386</user_id><user_firstLast_name>Jasna Lajtner</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MAPS</proposal_type><proposal_call>2024</proposal_call><code>MAPS-2024-9713</code><acronim><![CDATA[FACEMUSSEL]]></acronim><duration>01.06.2025 - 31.05.2029</duration><status>U tijeku</status><financ_value>80.101,70 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>1292, 25082, 874029, </team_members_id><team_members_names><![CDATA[Marina Piria, Ivan Špelić, Stjepan Novosel, ]]></team_members_names><keywords_hr><![CDATA[konzervacija, reprodukcija, adaptacija, mikrobiom, fenotipska plastičnost, metilacija DNA]]></keywords_hr><keywords_en><![CDATA[conservation, reproduction, adaptation, microbiome, phenotypic plasticity, DNA methylation]]></keywords_en><summary_hr><![CDATA[Slatkovodni školjkaši (Unionidae) su jedna od najugroženijih skupina slatkovodnih životinja. Nedavni porast masovnih izumiranja unutar kritično ugroženog kompleksa vrsta Unio crassus (koji obuhvaća U. crassus (s. str.) i U. nanus) sugerira da globalno zatopljenje značajno doprinosi padu brojnosti školjkaša. Ipak, neke su populacije stabilne unatoč povećanju temperatura. Čimbenici odgovorni za ovu varijabilnost nisu jasni. Pretpostavljamo da: 1) klimatske promjene neizravno utječu na otpornost školjkaša, pri čemu povišene temperature pogoduju razvoju patogena i parazita; 2) otpornost školjkaša uvjetovana je pojačanim imunološkim odgovorom i reakcijom na toplinski šok; i 3) vrste U. crassus (s. str.) i U. nanus su podjednako pogođene ugibanjem, pri čemu su hibridi osjetljiviji od genetski čistih jedinki. Prvo ćemo provesti populacijsku genomsku studiju u Hrvatskoj i Poljskoj, odabirom 400 jedinki iz 40 populacija (WP1). Generirat ćemo podatke sekvenciranjem cijelog genoma kako bismo identificirali njihovu genetsku pozadinu, istražili genetsku raznolikost i povezanost te otkrili znakove lokalne adaptacije. U WP2 odabrat ćemo šest populacija (tri dobrog i tri lošeg stanja) u Hrvatskoj i Poljskoj. Prikupit ćemo podatke o okolišnim značajkama, morfometriji školjkaša, mikrobiomu vode i školjkaša, parazitima školjkaša, te epigenomici i transkriptomici tkiva stopala i škrga odabirom 10 jedinki po populaciji prije i nakon reproduktivne sezone. U WP3 ćemo radiotagirati 100 jedinki po populaciji kako bismo pratili reproduktivni napor tijekom sezone razmnožavanja. Usporedit ćemo po pet jedinki najlošijeg i najboljeg stanja kondicije analizirajući njihov mikrobiom, oblik školjke, prisutnost parazita te transkriptomske i epigenomske profile. Ovaj projekt je nov po svom sveobuhvatnom pristupu razumijevanja ugroženosti i otpornosti slatkovodnih školjkaša, kombinirajući visoko precizna mjerenja kondicije, molekularne odgovore i detaljno ispitivanje abiotičkih i biotičkih stresora.]]></summary_hr><summary_en><![CDATA[Freshwater mussels (Unionidae) are among the most endangered freshwater animals. Recent increases in mass extinctions within the critically endangered Unio crassus species complex (encompassing U. crassus (s. str.) and U. nanus) suggest global warming significantly contributes to mussel decline. However, some populations are unaffected despite elevated temperatures. The factors responsible for this variability are unclear. We hypothesize that: 1) mussel decline is an indirect effect of climate change, with elevated temperatures favoring pathogen and parasite outbreaks; 2) mussel resilience is mediated by enhanced immune and heat-shock responses; and 3) U. crassus (s. str.) and U. nanus are similarly impacted by mortality events, with hybrids performing worse than non-admixed individuals. We will first perform a population genomics study in Croatia and Poland, targeting 400 individuals from 40 populations (WP1). We will generate whole-genome resequencing data to identify their genetic background, investigate genetic diversity and connectivity, and uncover local adaptation signatures. In WP2, we will select six populations (three resistant and three affected) in Croatia and Poland. We will collect data on environmental parameters, water and mussel microbiome, mussel parasite communities, shell morphometrics, and whole-genome epigenomics and transcriptomics of foot and gill tissues from ten mussels per population before and after the reproductive season. In WP3, we will radiotag 100 mussels per population to monitor reproductive effort throughout the breeding season. We will compare the five fittest and five least fit individuals regarding their microbiome, parasites, and transcriptomic and epigenomic profiles. This project is novel in its comprehensive approach to understanding freshwater mussel decline and resilience, combining high-resolution fitness measurements, molecular responses, and a detailed examination of abiotic and biotic stressors.]]></summary_en></project><project>
<id>17269</id><title_hr><![CDATA[Prekogranična suradnja u gospodarenju vodama između  zemalja članica EU i trećih zemalja: analiza elastičnosti  upravljanja   i  kreiranje hidropolitičkog modela]]></title_hr><title_en><![CDATA[Transboundary water cooperation between EU member states and third countries: governance resilience analysis and hydropolitical model-building ]]></title_en><user_id>19009</user_id><user_firstLast_name>Lidija  Tadić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MAPS</proposal_type><proposal_call>2024</proposal_call><code>MAPS-2024-7047</code><acronim><![CDATA[TWCEU]]></acronim><duration>01.07.2025 - 30.06.2029</duration><status>U tijeku</status><financ_value>50.656,90 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Pravo, Politologija, </scie_field_hr><scie_field_en>Law, Political Science, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Građevinski i arhitektonski fakultet Osijek]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Civil Engineering and Architecture Osijek]]></institution_en><team_members_id>19631, 873113, </team_members_id><team_members_names><![CDATA[Tamara Brleković, Luka Juretić, ]]></team_members_names><keywords_hr><![CDATA[gospodarenje vodama, Europska Unija,  upravljanje vodama,  vodna politika EU, prekogranična suradnja, vodna diplomacija]]></keywords_hr><keywords_en><![CDATA[ Water management, European Union, Water governance,  EU Water Policy, Transboundary cooperation , Water diplomacy]]></keywords_en><summary_hr><![CDATA[Prekogranična suradnja u području vodnog gospodarstva unutar Europske Unije predmet  je vrlo harmonizoranog  pravnog sustava   pod okriljem EU Okvirne direktive o vodama  (ODV). Također,  države članice  EU  imaju obvezu  na najbolji mogući način implementirati  ciljeve ODV-a prema trećim državama  na području prekograničnih slivova.  Posljedično, Europska komisija i EU članice, posljednja dva desetljeća  vrlo dosljedno nastoje proširiti provedbu vodne politike EU, kao i upravljačke mehanizme  na slivna područja  izvan EU političkih granica. Koliko su ta nastojanja uspješna uglavnom nije poznato. Ovaj istraživački projekt ima za cilj definirati interakcije između EU, nacionalnih i međunarodnih vodnih politika i prava na 4 sliva  ( rijeke Rajne, Rhône, Po i Dunava) koji se protežu na teritorije zemalja članica EU i  onih koje to nisu. Istraživanje se sastoji od empirijske i teorijske komponente. Empirijski dio će se fokusirati na skupljanje znanja  o postojećim gospodarenjima i mehanizmima upravljanja vodama na 4 odabrana sliva. Polazište je analiza stanja upravljanja vodama na slivovima, posebice onima koje dijele zemlje koje su članice i one koje nisu članice EU. Empirijski dio zaključno daje procjenu učinkovitosti  postojeće suradnje na osnovu sljedećih metoda: pregled literature, analize postojećih baza podataka,modeliranja, provedbe upitnika/anketa s relavantnim dionicima.Teorijska komponenta će zaključke dobivene empirijskim putem pretočiti u širi zakonski i institucionalni okvir prekograničnih upravljanja vodama i prekogranične vodne politike. Teorijski dio ima za cilj sintetizirati različite pokretače i inhibitore  konflikata i suradnje na podslivovima, uključujući njihove indikatore. Ova analiza daje novi i multidisciplinarni koncept  prekograničnih odnosa povezujući hidrološke, pravne i političke znanstvene metode.]]></summary_hr><summary_en><![CDATA[Transboundary water cooperation within the EU is subject to highly harmonised legal regime dominated by the EU’s Water Framework Directive (WFD).Yet, EU member states are under a “best-effort” obligation to implement the objectives of the WFD vis-a-vis third countries in shared river basins. Consequently, the EC and EU member states have, over the past two decades, been consistently working on expand the application of the EU’s own water policy priorities and governance mechanisms to catchment areas spanning the EU’s political borders. How far these efforts have succeeded, however, remain largely unknown. This research project aims to map out the interactions between EU, national and international water policy and law in four river basins shared by EU and non-EU countries (the Rhône, the Rhine, the Po and the Danube) The research will comprise an empirical and a theoretical component. The empirical component will focus on gathering  knowledge on the actual management and governance mechanism of the four river sub-basins. The starting point will be a state-of-play analysis of the  water management problems of the basins, focusing on sub-basins shared by EU and non-EU countries alike. The empirical part will conclude with an assessment of the effectiveness of existing cooperation.The methods includes literature review, analysis of existing databases, modelling and  information gathered through questionnaires, surveys and interviews with  relevant stakeholders.The theoretical component will embed the conclusions of the empirical research into the broader legal and institutional framework of transboundary water governance and hydropolitics. The theoretical part will aim at synthetising abstract of diverse character drivers and inhibitors of conflict and cooperation in the sub-basins, together with their  indicators. This analysis will provide a novel  and multidisiplinary concept of co-riparian relations  by  combining hydrological, legal and political science methods.]]></summary_en></project><project>
<id>17291</id><title_hr><![CDATA[Promicanje učinkovitijeg sustava prijevoza poboljšanjem zdravlja vozača autobusa]]></title_hr><title_en><![CDATA[Promoting Effective Transport through Healthy Bus Drivers]]></title_en><user_id>87</user_id><user_firstLast_name>Goran Gajski</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MAPS</proposal_type><proposal_call>2024</proposal_call><code>MAPS-2024-3581</code><acronim><![CDATA[PROMETHEUS]]></acronim><duration>01.07.2025 - 30.06.2029</duration><status>U tijeku</status><financ_value>80.128,38 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Javno zdravstvo i zdravstvena zaštita, Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Public health and health services, Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Institut za medicinska istraživanja i medicinu rada]]></institution_hr><institution_en><![CDATA[Institute for Medical Research and Occupational Health]]></institution_en><team_members_id>171, 1223, 865031, 866664, 1376, 1490, 25491, 2649, 21444, 4161, 1212, 23825, 216, 215, 868482, 856213, 879, 1209, 19039, 872819, 872818, 868466, 29739, 865628, 18906, </team_members_id><team_members_names><![CDATA[Marko Gerić, Mirta Milic, Katarina Matković, Luka Kazensky, Darija Klinčić, Marija Dvoršćak, Karla Jagić, Blanka Tariba Lovaković, Andreja Jurič, Irena Brčić Karačonji, Sanja Stipičević, Zrinka Franić, Tatjana Orct, Ankica Sekovanić, Juraj Vdović, Marija Macan, Jelena Macan, Željka Babić, Lucia Nanić, Marija Kujundzic, Emin Veledar, Adriana Gustovarac, Franka Šakić, Maja Nikolic, Matijana Jergović, ]]></team_members_names><keywords_hr><![CDATA[vozači autobusa, transport, biomarkeri, medicina rada, javno zdravstvo]]></keywords_hr><keywords_en><![CDATA[bus drivers, transport, biomarkers, occupational medicine, public health]]></keywords_en><summary_hr><![CDATA[U eri klimatskih promjena, ograničenja resursa i nužnog prijelaza na održive načine života, proizvodnje i prijevoza, učinkovit sektor javnog prijevoza od iznimne je važnosti. Jedan od gorućih problema današnjice unutar ovog sektora jest veliki nedostatak vozača autobusa. Izazovi koji umanjuju interes za odabir ovog  zanimanja uključuju stres, ergonomska ograničenja i mnoge fizičke, kemijske i biološke izloženosti. Unatoč propisima koji nalažu redovite liječničke preglede, globalno se bilježi pogoršanje zdravlja vozača i visoka stopa izostanaka s posla. Cilj PROMETHEUS projekta jest poboljšati preventivnu vrijednost zakonskog nadzora uvjeta na radu integracijom biomonitoringa zajedno sa zdravstvenim obrazovanjem vozača. Cilj nam je i istražiti njegovu primjenjivost i učinak na zdravlje te dobrobit vozača u dvogodišnjem praćenju. Naš inovativni pristup kombinacija je epidemiološke, biološke i medicinske ekspertize te iskustva rada unutar okvira za promicanje zdravlja na radu kao što su Total Worker Health, Stay-at-Work, Salutogenesis, te Patient and Public Involvement in Research. Projekt integrira prevenciju bolesti te sigurnosnih i zdravstvenih opasnosti povezanih s radom i promicanje zdravlja, a sve radi unaprjeđenja dobrobiti vozača. PROMETHEUS će služiti kao alat za pružanje znanstveno utemeljenih podataka o profesionalnoj izloženosti u sektoru javnog prijevoza. Projekt će stvoriti nova saznanja o profesionalnim rizicima vozača te omogućiti kreatorima politika EU i Švicarske da donose bolje informirane odluke o budućim propisima za sektor javnog prijevoza.]]></summary_hr><summary_en><![CDATA[In the era of climate change, resource limitation, and the necessary transition towards sustainable modes of life, production, and transportation, the public transport sector (PTS) is of paramount importance. Today, the PTS suffers from an unprecedently high shortage of bus drivers (BDs). BD occupation is challenging in terms of stress, ergonomic constraints, and many physical, chemical, and biological exposures. Despite regulations that impose regular medical check-ups, there is globally a decline in BDs’ health and high absenteeism, which need to be addressed. The goal of PROMETHEUS is to improve the preventive value of the statutory occupational health (OH) surveillance (OHS) by integrating biomonitoring coupled with health education of BDs. We aim to investigate its feasibility and effect on BDs’ health and wellbeing in a 2-year follow-up. Our innovative approach is the combination of strong epidemiological, biological, and medical expertise with occupational health promotion frameworks such as Total Worker Health, Stay-at-Work, Salutogenesis, and Patient and Public Involvement in Research. This integrates work-related safety and health hazards prevention with health promotion and disease prevention for the advancement of BDs’ wellbeing. PROMETHEUS will serve as a tool for providing scientifically based data on occupational exposures in the PTS. It will generate new knowledge on the BDs’ occupational risks allowing EU and Swiss policymakers to make better-informed decisions about future regulations in this particular setting.]]></summary_en></project><project>
<id>17297</id><title_hr><![CDATA[Multimodalna robotska inspekcija i praćenje morskih algi]]></title_hr><title_en><![CDATA[MultI-Modal Robot Inspection and monitoring of Sea Kelp ]]></title_en><user_id>865864</user_id><user_firstLast_name>Fausto Miguel Pascoal Ferreira</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>WEAVE</proposal_type><proposal_call>2024</proposal_call><code>WEAVE-2024-3600</code><acronim><![CDATA[MIMISK]]></acronim><duration>15.09.2025 - 14.09.2029</duration><status>U tijeku</status><financ_value>199.043,64 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, Interdisciplinarne tehničke znanosti, </scie_field_hr><scie_field_en>Electrical engineering, Interdisciplinary technological sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>5962, 20001, 25385, 874162, </team_members_id><team_members_names><![CDATA[Nikola Mišković, Đula Nađ, Barbara Arbanas Ferreira, Waseem Akram, ]]></team_members_names><keywords_hr><![CDATA[aerial-aquatic,monitoring,biodiversity,ecology,robot,seaweed,sea kelp]]></keywords_hr><keywords_en><![CDATA[aerial-aquatic,monitoring,biodiversity,ecology,robot,seaweed,sea kelp]]></keywords_en><summary_hr><![CDATA[Ekološko bogatstvo pomorskih područja i slatkovodnih ekosustava suočava se sa značajnim prijetnjama utjecaja koje je uzrokovao čovjek, kao što su onečišćenje, prekomjerni izlov ribe i klimatske promjene. Tradicionalne metode praćenja ovih kritičnih okruženja plavog ugljika (BCE) često ne uspijevaju. Ovaj prijedlog ima za cilj iskoristiti napredne tehnologije u zračno-vodenoj, multimodalnoj robotici za praćenje zdravlja i sekvestraciju ugljika BCE-a, s fokusom na poboljšanje praćenja bioraznolikosti, povećanje očuvanja i podržavanje ublažavanja klimatskih promjena u ekosustavima divljih i uzgojenih morskih algi.Naše robotske tehnologije dizajnirane su za poboljšanje nadzora i uzgoja morskih algi, osobito u složenim obalnim okruženjima. Tradicionalne metode poput satelitskih slika i ručnog uzorkovanja imaju ograničenja. Roboti mogu učinkovito prikupljati podatke visoke rezolucije o rastu morskih algi, zdravlju i uvjetima okoliša, čak i na teško dostupnim područjima. Naše rješenje omogućuje brzu implementaciju i nadzor u velikim bazenima i uzgajalištima morskih algi. Nadovezujući se na dron MEDUSA, ovaj sustav kombinira agilnost iz zraka s detaljnim podvodnim pregledom.Cilj nam je poboljšati MEDUSA-ine mogućnosti poboljšanjem tehnologije integracije senzora, navigacije, autonomije i manipulacije. Ovaj sustav će uključivati planiranje misije velikih razmjera, podatke o satelitskom pozicioniranju i multimodalne mogućnosti. Takav napor zahtijeva međunarodnu suradnju za različite tehničke ekspertize između Laboratorija za robotiku održivosti (Empa, EPFL) i Laboratorija za podvodne sustave i tehnologiju (Sveučilište u Zagrebu, FER).Rješavanjem trenutnih ograničenja robotskog sustava i poboljšanjem MEDUSA-inih sposobnosti, cilj nam je otključati potencijal morske trave kao skalabilne, isplative metode za hvatanje ugljika. Naše rješenje poboljšat će učinkovitost i održivost uzgoja morskih algi i značajno doprinijeti globalnim naporima u borbi protiv klimatskih promjena.]]></summary_hr><summary_en><![CDATA[The ecological richness of Croatia&#39;s maritime areas and Switzerland&#39;s freshwater ecosystems faces significant threats from man-made impacts such as pollution, overfishing, and climate change. Traditional methods of monitoring these critical blue carbon environments (BCEs) often fall short. This proposal aims to leverage advanced technologies in aerial-aquatic, multi-modal robotics for health monitoring and carbon sequestration of BCEs, with a focus on improving biodiversity monitoring, enhancing conservation, and supporting climate mitigation in both wild and farmed seaweed/sea kelp ecosystems.Our robotic technologies are designed to enhance seaweed monitoring and farming, particularly in complex coastal environments. Traditional methods like satellite imagery and manual sampling have limitations. Robots can efficiently gather high-resolution data on seaweed growth, health, and environmental conditions, even in hard-to-reach areas. Our solution allows for rapid deployment and monitoring across large seaweed basins and farms. Building on the MEDUSA drone, this system combines aerial agility with detailed underwater inspection.We aim to enhance MEDUSA’s capabilities by improving sensor integration, navigation, autonomy, and manipulation technologies. This system will incorporate large-scale mission planning, satellite positioning data, and multi-modal capabilities. Such an effort necessitates international collaboration for varying technical expertise between the Laboratory of Sustainability Robotics (Empa, EPFL) and the Laboratory for Underwater Systems and Technology (University of Zagreb, FER).By addressing current robotic system limitations and enhancing MEDUSA&#39;s capabilities, we aim to unlock the potential of seaweed as scalable, cost-effective methods for carbon capture. Our solution will improve the efficiency and sustainability of seaweed farming and contribute significantly to global efforts in combating climate change.]]></summary_en></project><project>
<id>17300</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Narda Krnetić Blečić]]></title_hr><title_en><![CDATA[]]></title_en><user_id>869638</user_id><user_firstLast_name>Narda Krnetić Blečić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-8212</code><acronim><![CDATA[]]></acronim><duration>03.01.2025 - 17.04.2025</duration><status>U tijeku</status><financ_value>8.925,00 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Pravo, </scie_field_hr><scie_field_en>Law, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Pravni fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Law]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Izazovi koji proizlaze iz klimatske krize, aktualnih ratova i nemira, energetskog siromaštva nameću potrebu za odgovornijim i svjesnijim upravljanjem energetskim resursima. Upravljanje energetskim resursima nužno je urediti pravnim propisima, kako na razini Europske unije, tako i na razini pojedinih država članica. Osim pozitivizacije energetskog prava, nužno je definirati podjelu odgovornosti u zakonodavnom procesu. Posljedično, vrlo važan dio istraživanja činit će analiza podjele nadležnosti normativne aktivnosti u energetskom pravu između država članica i Europske unije. Energetsko se pravo, između ostalog, koristi za liberalizaciju energetskih tržišta i osiguravanje poštene tržišne utakmice što bi sve trebalo donijeti benefite za poslovne subjekte, ali i same građane, prije svega odražavanjem na cijenu električne energije. Osiguravanje primjene pravila tržišnog natjecanja trebalo bi rezultirati smanjenjem cijene pružanja usluge opskrbe energijom i poticanjem inovacija i ulaganja u nove i obnovljive izvore energije i tehnologije. Koncepti održivosti i održivog razvoja imaju značajan utjecaj na donošenje energetskih politika i prava Europske unije. Valja stoga detaljno razjasniti i razgraničiti značenja tih koncepata što će biti i važan dio istraživanja.Organizacija-domaćin: Univerza v Mariboru, Pravna fakulteta, Slovenija]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>17301</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Josip Kir Hromatko]]></title_hr><title_en><![CDATA[]]></title_en><user_id>865417</user_id><user_firstLast_name>Josip Kir Hromatko</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-4584</code><acronim><![CDATA[]]></acronim><duration>03.03.2025 - 02.09.2025</duration><status>U tijeku</status><financ_value>15.640,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Upravljanje dinamikom vozila najčešće podrazumijeva sigurnosne sustave poput sprječavanja izvrtanja u zavojima ili proklizavanja kotača na skliskoj podlozi. U istraživanju se za takve sustave često koristi modelsko prediktivno upravljanje, koje pronalazi najbolje upravljačke akcije unutar određenog vremenskog horizonta koristeći model sustava i predikciju njegovog ponašanja. Glavne prednosti takvog načina upravljanja su intuitivnost, sposobnost upravljanja sustavima s više ulaza i izlaza, mogućnost definiranja poznatih ograničenja sustava te određena teoretska svojstva, tj. garancije. Nedostaci ovog pristupa su ovisnost o kvaliteti modela te složenost eksplicitnog razmatranja modelskih nepoznanica. S druge strane, velik broj istraživača bavi se i algoritmima strojnog učenja, s posebnim naglaskom na podržano učenje za primjene u upravljanju sustavima. Cilj podržanog učenja je sličan onom klasičnih metoda upravljanja — naći optimalne upravljačke akcije, koje će maksimizirati nagradu. Takvim metodama mogu se pronaći odgovarajuće akcije za vrlo složene sustave, a jedini uvjet je dovoljan skup podataka, tj. informativna interakcija sa sustavom. Međutim, u ovom slučaju uglavnom ne postoje nikakve garancije, a rezultat općenito nema fizikalnu interpretaciju. Cilj predloženog usavršavanja je povezati glavne prednosti oba pristupa — krenuti od fizikalnog modela i definirati razumljivu strukturu upravljanja, a zatim „popuniti rupe” koristeći podatke sa stvarnog sustava. U kontekstu upravljanja dinamikom vozila, ovakav pristup bi omogućio maksimalne performanse (ili minimalnu potrošnju energije) uz poštivanje sigurnosnih ograničenja, objašnjivost algoritma upravljanja i primjenjivost u standardnim vozilima.Organizacija-domaćin: Norwegian University of Science and Technology, Norveška]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>17302</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Zvonimir Lipšinić]]></title_hr><title_en><![CDATA[]]></title_en><user_id>867676</user_id><user_firstLast_name>Zvonimir Lipšinić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-6015</code><acronim><![CDATA[]]></acronim><duration>31.01.2025 - 02.03.2025</duration><status>U tijeku</status><financ_value>2.635,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, </scie_field_hr><scie_field_en>Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Asistent Zvonimir Lipšinić sa Sveučilišta u Zagrebu, Fakultet strojarstva i brodogradnje, radi na naprednom istraživanju u području inženjerstva sustava (eng. Systems Engineering). Cilj njegovog doktorskog istraživanja je razviti i predložiti sistematski pristup korištenju Model-Based Systems Engineering (MBSE) metodologije u određenim aspektima procesa konstruiranja i razvoja kompleksnih proizvoda i sustava. S obzirom na širinu područja i povećanu važnost održivosti u razvoju novih proizvoda i sustava, predloženi sistematski pristup fokusirao bi se na podršku strateškom odlučivanju u procesima primjene strategija cirkularne ekonomije (CE) sa svrhom produženja vijeka trajanja mehatroničkih sustava. Predloženo usavršavanje omogućit će mu pristup naprednim metodologijama i alatima u području inženjerstva sustava i području znanosti o podacima. Ovaj proces ne samo da će obogatiti kvalitetu i dubinu istraživanja, već će također omogućiti brzu i efikasniju implementaciju rezultata u industriji. Njegova istraživanja također uključuju i daljnju suradnju s njemačkim sveučilištima TU Ilmenau i TU Clausthal te hrvatskom tvrtkom RONNA Medical. Kroz ove suradnje, asistent će raditi na praktičnoj primjeni rezultata istraživanja u industriji, to će omogućiti validaciju predloženog sistematskog pristupa i doprinijeti razumijevanju i primjeni naprednih metoda računalne podrške konstruiranju u industriji. Stečeno znanje također će biti iskorišteno za razvoj novog kolegija na diplomskom studiju, čime će se studentima pružiti najnovija saznanja u području inženjerstva sustava. Rezultati istraživanja bit će predstavljeni na međunarodnim konferencijama i objavljeni u znanstvenim časopisima, omogućujući široku razmjenu znanja s globalnom znanstvenom zajednicom.Organizacija-domaćin: Technische Universität Ilmenau, Njemačka]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>17308</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Lejsa Jakupovic]]></title_hr><title_en><![CDATA[]]></title_en><user_id>858443</user_id><user_firstLast_name>Lejsa Jakupovic</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-3418</code><acronim><![CDATA[]]></acronim><duration>24.02.2025 - 27.03.2025</duration><status>U tijeku</status><financ_value>2.720,00 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Farmacija, </scie_field_hr><scie_field_en>Pharmaceutical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Farmaceutsko-biokemijski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Pharmacy and Biochemistry]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Biljne aktivne sastavnice mogu utjecati na izgled i zdravlje kože. Stoga se biljni ekstrakti često koriste u izradi dermatokozmetičkih proizvoda. Kako bi porijeklo svih sastavnica takvih proizvoda bilo što prihvatljivije za potrošača i okoliš, poželjno je za izradu ekstrakata koristiti ,zelena“ otapala koja su biorazgradiva i netoksična kako za organizam tako i za okoliš. Takvi proizvodi često ne djeluju samo na izgled nego i na metabolizam i zdravlje kože te se time mogu svrstati u kategoriju dermatokozmetike. U idealnom slučaju oni bi trebali biti izrađeni u skladu s rezultatima znanstvenih istraživanja te zadovoljavati stroge standarde kvalitete kako bi se osigurao željeni učinak. Uz željene biološke značajke, suvremeni ekstrakti u dermatokozmetici trebaju ispuniti i dodatne zahtjeve. Prilikom njihove izrade, uključujući vrijeme razvoja, proizvodnje i kontrole kvalitete, treba razmotriti i okolišne čimbenike kao i brigu o dobrobiti životinja. Stoga je dizajn „zelenih” i održivih metoda ekstrakcije vrlo aktualna multidisciplinarna tema. Ekstrakcija potpomognuta ultrazvukom se zbog svoje jednostavnosti, cjenovne pristupačnosti te visokog prinosa i učinkovitosti smatra jednom od najvažnijih zelenih ekstrakcijskih tehnika. Odlikuju je visoka ponovljivost, niska potrošnja otapala, i brza stopa ekstrakcije što je čini vrlo prikladnom za ekstrakciju kemijski osjetljivih aktivnih sastavnica poput biljnih polifenola. Kako bi postupak ekstrakcije bio ekološki prihvatljiv i otapala koja se koriste za ekstrakciju trebaju, uz veliku moć otapanja, biti biorazgradiva, netoksična i nezapaljiva. Eutektična otapala su smjese dvaju ili vise tvari od kojih dio ima ulogu donora vodikove veze dok druge djeluju kao akceptori vodikove veze. Za njih je karakteristično da su na sobnoj temperaturi u tekućem stanju te da smjesu karakterizira niža eutektična točka od sastavnica smjese. Ukoliko su sastavnice eutektičnog otapala prirodnog porijekla takva su otapala biorazgradiva i netoksična prema okolišu i ljudima čime se mogu svrstati u zelena otapala. Za uvođenje novih postupaka ekstrakcije s novim otapalima potrebno je provesti istraživanje koje će obuhvatiti različite postupke i metodologije pripreme ekstrakata te ispitati sastav i vrstu aktivnih supstanci pomoću LC/MS analize. Mobilnost doktoranda i suradnja sa Sveučilištem u Bialystoku, koje ima iskustvo u istraživanju ekstrakcija primjenom eutektičnih otapala, omogućit će usvajanje novih znanja i vještina potrebnih za provođenje takvih ekstrakcija na matičnom Fakultetu. Očekivane koristi korištenja netoksičnih otapala za ekstrakciju biljnih vrsta mogle bi biti višestruke i dovesti do novih spoznaja primjene odabranih biljnih vrsta u dermatokozmetici.Organizacija-domaćin: Medical University of Bialystok, Poljska]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>17309</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Elena Petrović]]></title_hr><title_en><![CDATA[]]></title_en><user_id>865016</user_id><user_firstLast_name>Elena Petrović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-2883</code><acronim><![CDATA[]]></acronim><duration>01.02.2025 - 01.08.2025</duration><status>U tijeku</status><financ_value>15.470,00 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Institut za poljoprivredu i turizam]]></institution_hr><institution_en><![CDATA[Institute of Agriculture and Tourism in Poreč]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Predloženo znanstveno-istraživačko usavršavanje usmjereno je na istraživanje gljiva izoliranih s masline, važne mediteranske vrste. Cilj je steći nova znanja i vještine koje će omogućiti prepoznavanje i točnu identifikaciju gljiva. Navedeno će dati uvid u vrste koje se nalaze na maslini i otvoriti mogućnosti daljnjih testiranja na izolatima, poput testiranja patogenosti, učinkovitosti sredstava za zaštitu bilja na patogene i dr., čime će se olakšati razvoj novih i učinkovitijih metoda zaštite maslina od bolesti koje uzrokuju patogene gljive. Usavršavanje će se fokusirati na dvije glavne metode — detaljno proučavanje morfoloških karakteristika gljiva i analizu njihove genetske strukture. Očekuje se da će ovo istraživanje imati značajan utjecaj na mikologiju kroz prepoznavanje različitih vrsta gljiva i upis sekvenci u nacionalnu bazu podataka GenBank. Također, navedeno će imati utjecaj na poljoprivrednu proizvodnju, posebno u mediteranskim regijama, jer gljivične bolesti mogu smanjiti prinos maslina i uzrokovati ekonomske gubitke. Točna identifikacija gljiva će pridonijeti očuvanju okoliša i smanjenju uporabe štetnih kemikalija u poljoprivredi zbog otvaranja mogućnosti izrade plana zaštite bilja prilagođenog patogenoj vrsti koja uzrokuje oboljenje. Rezultati ovog usavršavanja moći će se koristiti u daljnjim projektima s ciljem boljeg razumijevanja bolesti biljaka i osmišljavanja načina na koje se možemo boriti protiv njih na ekološki prihvatljiv način. Razvijene metode će dugoročno koristiti poljoprivrednicima i društvu općenito. Istovremeno, ovo usavršavanje će mladoj znanstvenici omogućiti razvoj karijere kroz stjecanje novih vještina, sudjelovanje u međunarodnom istraživanju i objavljivanje znanstvenih radova, čime će se dodatno unaprijediti znanstveni doprinos u području zaštite bilja.Organizacija-domaćin: Universidade de Aveiro, Portugal]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>17310</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Marin Cukrov]]></title_hr><title_en><![CDATA[]]></title_en><user_id>855521</user_id><user_firstLast_name>Marin Cukrov</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-8384</code><acronim><![CDATA[]]></acronim><duration>01.03.2025 - 31.08.2025</duration><status>U tijeku</status><financ_value>15.640,00 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Institut za poljoprivredu i turizam]]></institution_hr><institution_en><![CDATA[Institute of Agriculture and Tourism in Poreč]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Istraživačka grupa na Institutu za poljoprivredu i turizam u Poreču (IPTPO), pod vodstvom dr.sc. Igora Paskovića, u čijem radu sudjeluje asistent Marin Cukrov, bavi se istraživanjem utjecaja mineralnih hraniva i elicitora na obrambeni, sekundarni metabolizam bilja. Grupa na zavodu za ekologiju biljne proizvodnje Švedskog sveučilišta poljoprivrednih znanosti u Uppsali, pod vodstvom izv. prof. dr. sc. Velemira Ninkovića dugi niz godina već istražuje značaj biljne komunikacije putem emitiranih hlapljivih spojeva u agroekološkim, višetrofnim interakcijama. Obzirom da su i ti spojevi produkti biljnog obrambenog metabolizma, tijekom usavršavanja asistent će istražiti utjecaj specifičnog mineralnog elicitora silicija na emisije biljnih hlapljivih spojeva. Istovremeno, originalnim pristupom u postavkama svog istraživanja, asistent će preispitati izravnost silicijeve signalne uloge u kompleksnoj mreži fitohormona i hlapljivih spojeva. Kako se ista očituje isključivo uslijed fiziološkog stresa, te budući da stres već sam po sebi uzrokuje interferencije u mreži signalno-obrambenih procesa koordiniranih fitohormonima, nepoznato je utječe li silicij na istu izravno ili pak posredno, ateriranjem stresa. Asistent će stoga u sklopu svog usavršavanja izložiti silicijem-kondicionirane biljke egzogenim, hlapljivim fitohormonalnim podražajima kojima će biljkama signalizirati da je stres izvjestan bez da ga nametne. Tako će pobuditi signalne procese koji bi se pokrenuli u stvarnom prisustvu stresa, a istovremeno anulirati fiziološka i metabolička opterećenja koja stres inače uzrokuje te utvrditi pozadinski mehanizam silicijeve navodne signalne uloge. Tijekom usavršavanja u Švedskoj, asistent će se pobliže upoznati s metodologijom provedbe istraživanja komunikacije bilja, te uzorkovanja konstitutivnih i induciranih hlapljivih spojeva. Koristeći kapacitete zavoda grupe domaćina, usavršit će se u analitici emisija hlapljivih spojeva te identificirati i kvantificirati iste vezanim sustavom plinska kromatografija-spektrometar masa (GCMS). Stečena znanja i vještine asistent će primijeniti u sklopu budućih istraživanja u kontekstu mineralne ishrane bilja i njenih ekoloških implikacija.Organizacija-domaćin: University of Agricultural Sciences Uppsala, Švedska]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>17311</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Luka Matijević]]></title_hr><title_en><![CDATA[]]></title_en><user_id>868423</user_id><user_firstLast_name>Luka Matijević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-8006</code><acronim><![CDATA[]]></acronim><duration>01.02.2025 - 18.07.2025</duration><status>U tijeku</status><financ_value>14.280,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Galaksije su jedni od najvećih objekata u svemiru, sazdani od zvijezda, međuzvjezdanog plina i prašine, te tamne tvari. Kroz evoluciju svemira, proces stvaranja zvijezda igra ključnu ulogu u razvoju i oblikovanju galaksija. Također, fizikalni procesi unutar i izvan galaksije mogu radikalno mijenjati distribuciju i efikasnost stvaranja zvijezda i međuzvjezdane tvari. Jedno od važnih pitanja u astronomiji jest kakav utjecaj na razvoj galaksija imaju vanjske galaktičke sile poput gravitacijske plimne sile s obližnjih galaksija i efekta ogoljenja plina zbog tlaka otpora međugalaktičkog plina. Galaksija NGC 2276 je neobična asimetrična galaksija u galaktičkoj grupi, koja je rijetki primjer galaksija na koju istovremeno djeluju obje vanjske sile. Promatranjem NGC 2276 i njene grupe u različitim valnim područjima (ultraljubičasto, optičko, infracrveno i milimetarsko) te s različitim astronomskim tehnikama (oslikavanje, spektri, radio-interferometrija) može se kvantificirati utjecaj gravitacijske sile i tlaka otpora na razvoj zvjezdanog diska, distribucije plina i povijest formiranja zvijezda tih galaksija. Glavni cilj ovog projekta jest usavršavanje asistenta Luke Matijevića na stranom znanstvenom institutu Astrononskom opservatoriju u Padovi (INAF-OAPD, Italija), pod mentorstvom znanstvenog suradnika Antonina Marasca. Znanstveni cilj mobilnosti jest mjerenje evolucije zvjezdanog diska galaksije NGC 2276, koji je glavni dio doktorskog rada asistenta. Dodatni ciljevi mobilnosti su usavršavanje u tehnikama promatranja s optičkim teleskopom (Opservatorij Asiago u Italiji) te u analizi spektara NGC 2276 galaksije.Organizacija-domaćin: Astronomski opservatorij u Padovi, Italija]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>17312</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Milan Petrović]]></title_hr><title_en><![CDATA[]]></title_en><user_id>855438</user_id><user_firstLast_name>Milan Petrović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-3515</code><acronim><![CDATA[]]></acronim><duration>16.04.2025 - 01.08.2025</duration><status>U tijeku</status><financ_value>9.180,00 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Informacijske znanosti, </scie_field_hr><scie_field_en>Information sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci]]></institution_hr><institution_en><![CDATA[University of Rijeka]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>17313</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Marin Đujić]]></title_hr><title_en><![CDATA[]]></title_en><user_id>869769</user_id><user_firstLast_name>Marin Đujić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-6291</code><acronim><![CDATA[]]></acronim><duration>01.03.2025 - 31.05.2025</duration><status>U tijeku</status><financ_value>7.820,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut za fiziku]]></institution_hr><institution_en><![CDATA[Institute of Physics in Zagreb]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Jedan od važnijih smjerova istraživanja u ovom stoljeću bavi se proučavanjem i iskorištavanjem kvantnih učinaka u tehnologiji. Završni proizvod ovog istraživanja bi bilo kvantno računalo široke primjene. Iako tehnološki giganti te velike znanstvene grupe već dulje vremena stvaraju i rade jednostavna kvantna računala s malim brojem kvantnih bitova (qubitova), skaliranje kvantnih računala na velik broj kvantnih bitova ostaje tehnološki vrlo zahtjevan i dosad nerješiv problem zbog šuma koji utječe na kvalitetu kvantne informacije. Kao jedno od mogućih rješenja nameće se proučavanje šuma u kvantnim sustavima te korištenje istog za ispravljanje ili poboljšanje dobivene kvantne informacije. Asistent će se u sklopu ovog usavršavanja na tri mjeseca pridružiti grupi prof. dr. Tobiasa Donnera na Sveučilištu ETH u Zurichu, koja je specijalizirana u proučavanju te visokoj kontroli kvantnih sustava s više tijela, konkretno tzv. Bose-Einsteinovog kondenzata (BEC-a), koji jako međudjeluje sa svjetlosnim poljem. Cilj eksperimenta je uvoditi nered u ovakav sustav preko svjetlosnog polja, čime bi se omogućilo izoliranje i analiziranje šuma koji nastaje. Ovakvo istraživanje bi značajno doprinijelo razumijevanju izvora šuma u kvantnim sustavima. Asistent će pritom skupiti iskustvo rada u velikoj grupi s vrhunskom opremom i svjetski priznatim rezultatima, te će tako stečeno znanje primijeniti u svom trenutačnom radu, kao i planiranju eksperimenta koji bi podržavao stvaranje BEC-a, prvog takvog u jugoistočnoj Europi.Organizacija-domaćin: ETH Zürich, Švicarska]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>17314</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Srećko Arandia-Krešić]]></title_hr><title_en><![CDATA[]]></title_en><user_id>865360</user_id><user_firstLast_name>Srećko Arandia-Krešić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-9198</code><acronim><![CDATA[]]></acronim><duration>01.02.2025 - 01.08.2025</duration><status>U tijeku</status><financ_value>15.470,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Interdisciplinarne tehničke znanosti, </scie_field_hr><scie_field_en>Interdisciplinary technological sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>17315</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Lea Ružanović]]></title_hr><title_en><![CDATA[]]></title_en><user_id>26987</user_id><user_firstLast_name>Lea Ružanović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-6145</code><acronim><![CDATA[]]></acronim><duration>14.01.2025 - 14.02.2025</duration><status>U tijeku</status><financ_value>2.720,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Ovo usavršavanje usmjereno je na istraživanje bioraznolikosti pauka u povremenim tekućicama, ekosustavima koji su specifični po svojoj sezonskoj dinamici koja uključuje suhu i vodenu fazu. Dosadašnja istraživanja uglavnom su se bavila vodenim beskralježnjacima, dok su kopneni organizmi, poput pauka, ostali u drugom planu. Pauci, kao indikatori u ovim ekosustavima, često nisu određivani do razine vrste, što otežava prepoznavanje ekoloških obrazaca u ovim ekosustavima na finijoj skali. Ovim projektom planira se odrediti oko 2.000 jedinki pauka od kojih su mnoge male, rijetke i složene za identifikaciju te zahtijevaju pomoć specijaliziranih taksonoma. Uzorci pauka su prikupljeni na četiri mediteranske povremene tekućice tijekom čitavog hidrološkog ciklusa koji uključuje lotičku (tekuću), lentičku (lokvice) i terestričku (kopnenu) fazu, što omogućuje uvid u raznolikost i rasprostranjivanje pauka tijekom cijele sezone. Nakon određivanja će se statistički ispitati razlike u brojnosti i raznolikosti pauka, između rijeka, vremenskih razdoblja te ključnih staništa: suhog riječnog korita, riparijske zone i okolnih kopnenih staništa. Očekuje se da će rezultati ovog usavršavanja pružiti uvid u raznolikost i sezonsku dinamiku pauka u dinamičnim ekosustavima povremenih tekućica, te omogućiti identifikaciju novih ili rijetkih vrsta pauka u Hrvatskoj, čime će se značajno obogatiti znanje o arahnofauni ovog dijela Europe. Ovaj program usavršavanja pomoći će u edukaciji stručnjaka za pauke kojih trenutno nedostaje u Hrvatskoj te omogućiti prezentiranje rezultata vezanih za pauke na međunarodnim znanstvenim skupovima te objavu u relevantnim znanstvenim časopisima.Organizacija-domaćin: Sveučilište Kaiserslautern-Landau, Njemačka]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>17316</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Teodora Prebeg]]></title_hr><title_en><![CDATA[]]></title_en><user_id>869799</user_id><user_firstLast_name>Teodora Prebeg</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-2768</code><acronim><![CDATA[]]></acronim><duration>27.01.2025 - 11.04.2025</duration><status>U tijeku</status><financ_value>6.375,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Kemijsko inženjerstvo, </scie_field_hr><scie_field_en>Chemical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet kemijskog inženjerstva i tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Chemical Engineering and Technology]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Ovo znanstveno-istraživačko usavršavanje orijentirano je na pripravu materijala koji je pogodna okolina za nasadnju stanica kože, te koji može poslužiti kao model tkiva kože u kliničkim ispitivanjima. Jedan od najvećih problema u kliničkoj praksi s presadnjom kože su infekcije koje otežavaju zarastanje i produljuju terapijski postupak za pacijenta. Stoga su se istraživanja usmjerila na razvoj modela kože koji u sebi sadrži antimikrobna svojstva te tako sprječava adheziju mikroba i tvorbu biofilma. U ovom istraživanju odabrani su hibridni hidrogelovi kao biomaterijal za nasadnju stanica. Poznato je kako su hidrogelovi pogodno okruženje za stanice i tkiva zbog visokog udjela vode u strukturi, a polimernu mrežu čini decelularizirana izvanstanična matrica u kojoj su prirodno prisutne biomakromolekule ključne za stanične procese: kolagen, glikozaminoglikani i ostale. Hidrogel je hibridiziran dodatkom polisaharida alginata i kitozana koji pokazuju ograničena antimikrobna svojstva, a kako bi se onda dodatno poboljšala, u materijal su dodani i antimikrobni peptidi koji su kemijskom vezom vezani na lance biomakromolekula. Dobivenom hibridnom hidrogelu odredit će se fizikalna i kemijska svojstva, provest će se studije na staničnoj kulturi te će se odrediti antimikrobna svojstva. Očekuje se da će dobiveni materijal unaprijediti dosadašnja istraživanja usmjerena na razvoj modela tkiva kože te da će pridonijeti razvoju antimikrobnih svojstava biomaterijala.Organizacija-domaćin: Universidad Carlos III de Madrid, Španjolska]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>17317</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Gaurav Pransu]]></title_hr><title_en><![CDATA[]]></title_en><user_id>865337</user_id><user_firstLast_name>Gaurav Pransu</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-4597</code><acronim><![CDATA[]]></acronim><duration>03.03.2025 - 30.05.2025</duration><status>U tijeku</status><financ_value>7.565,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut za fiziku]]></institution_hr><institution_en><![CDATA[Institute of Physics in Zagreb]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Novi kvantni materijali gdje postoji kompeticija različitih interakcija za osnovno stanje posjeduju često neočekivana i ponekad i funkcionalna osnovna stanja zanimljiva za daljnje primjene u izradi novih uređaja. Sustavi gdje se isprepliću magnetski i metalni podsustavi su jedan od primjera ovakvih materijala. Posebno zanimljivi predstavnici ovih sustava su visoko-temperaturni supravodiči kao i dihalkogenidi prijelaznih metala. Ova posljednja porodica materijala nudi mogućnost krojenja materijala po potrebi odabirom odgovarajućeg elementa iz periodnog sustava pošto cijela porodica obuhvaća širok spektar spojeva. Kako se radi o slojevitim materijalima, moguće ih je dobiti i u obliku tankih slojeva što je posebno zanimljivo za nano-uređaje. Zatim, uslijed slojevite strukture, moguće ih je interkalirati magnetskim ionima. U tom slučaju javlja se posebno zanimljiva interakcija magnetskih i metalnih sustava. Ovim usavršavanjem upravo se želi postići dublje razumijevanje ove interakcije kako bi se mogao iskoristiti puni potencijal ovih sustava te naučeni mehanizmi primijeniti na druge sustave ove šire klase kvantnih materijala.Organizacija-domaćin: Technische Universität Wien, Austrija]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>17318</id><title_hr><![CDATA[Novi pristup u determinističkoj ionskoj implantaciji s naprednim plinskim ionizacijskim detektorima]]></title_hr><title_en><![CDATA[New Approaches For Deterministic Precision Ion Implantation With Advanced Gas Ionisation Particle Detectors]]></title_en><user_id>4670</user_id><user_firstLast_name>Zdravko Siketić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>WEAVE</proposal_type><proposal_call>2024</proposal_call><code>WEAVE-2024-5444</code><acronim><![CDATA[IMAGION]]></acronim><duration>01.07.2025 - 30.06.2028</duration><status>U tijeku</status><financ_value>187.903,87 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>869771, 4629, 867163, 25285, </team_members_id><team_members_names><![CDATA[Fares Boussahoul, Milko Jakšić, Matija Matijević, Marko Brajković, ]]></team_members_names><keywords_hr><![CDATA[Plinski ionizacijski detektor, Implantacija pojedinačnih iona, Dušikove vakancije, Kolor centri, Implanter, Ionski snop, Ionska mikroproba, Dijamant]]></keywords_hr><keywords_en><![CDATA[Gas Ionization Chamber, Single Ion Implantation, Nitrogen Vacancies, Color Centers, Implanter, Ion Beams, Ion Microprobe, Diamonds]]></keywords_en><summary_hr><![CDATA[Cilj ovog projektnog prijedloga je razviti inovativan pristup u determinističkoj ionskoj iradijaciji i implantaciji koristeći detektor čestica s izravnom pred detekcijom, a  koja se bazira na ionizaciji plina. Ovaj sustav će raditi u energetskom rasponu od nekoliko desetaka keV do nekoliko MeV. Projekt će se provoditi u suradnji između ETH i IRB-a. Tim s ETH-a vodit će razvoj novog detektora iona baziranog na ionizaciji plina, koji će biti uparen s niskošumnim pred pojačalom na IRB-ovom niskoenergetskom implanteru (E_iona < 200 keV), a ujedno testiran s ionima MeV-skih energija na ETH. Istovremeno, IRB grupa će raditi na optimizaciji 200 kV implantera  u svrhu dobivanja fokusiranog ionskog snopa s lateralnom razlučivošću manjom od jednog mikrometra.Performanse novo razvijenog sustav biti će demonstrirane implantacijom dušika u dijamant s ciljem stvaranja aktivnih NV centara, što je ključan proces za napredak kvantnih tehnologija. Ujedno, cilj je stvoriti precizan raster NV centara u dijamantu za što je potrebna iznimna prostorna razlučivost i mogućnost brojanja pojedinačnih iona. Također se planira provesti sustavno istraživanje učinaka na  efikasnot konverzije NV centara i istražiti neželjene izvore elektromagnetskog šuma izazvane zračenjem u lokalnom okruženju oko mjesta implantacije. Implantirani uzorci bit će karakterizirani pomoću ODMR-a na ETH-u kako bi se procijenile performanse i učinkovitost razvijenog pristupa.Rezultati ovog projekta bit će predstavljeni na međunarodnim konferencijama i objavljeni u dva Q1 znanstvena časopisa, pružajući vrijedne uvide u područja ionske implantacije i kvantnih materijala.]]></summary_hr><summary_en><![CDATA[The aim of this project proposal is to develop an innovative approach to deterministic ion irradiation and implantation, utilizing a gas-based direct pre-impact particle detector. This system will operate over an energy range from tens of keV to several MeV. The project will be carried out in collaboration between ETH and the RBI groups. The ETH team will take the lead in developing a cutting-edge gas ionization detector, which will be paired with a low-noise preamplifier at the RBI&#39;s low-energy implanter (E_ions < 200 keV), and be tested with MeV ions at ETH. Simultaneously, the RBI group will optimize the 200 kV implanter to deliver ion beams with lateral positioning precision within sub-micorn range.The system’s capabilities will be demonstrated by implanting NV centers in diamond, a key process for advancing quantum technologies. By leveraging this system, it is planned to create a precise raster of NV centers in diamond with exceptional accuracy and single-ion counting capability. It is also planned to conduct systematic studies on conversion-yield effects and investigate unwanted radiation-induced sources of electromagnetic noise in the local environment around implantation sites. The implanted samples will be characterized using ODMR techniques at ETH to evaluate the performance and effectiveness of the approach.The results of this project will be presented at international conferences and published in two Q1 scientific journals, offering significant contributions to the fields of ion implantation and quantum materials.]]></summary_en></project><project>
<id>17320</id><title_hr><![CDATA[Kompjuter sa slučajnim impulsima za primjene u robotici i umjetnoj inteligenciji, zasnovan na SPAD diodama]]></title_hr><title_en><![CDATA[SPAD-based random pulse computer for robotics and AI applications]]></title_en><user_id>5697</user_id><user_firstLast_name>Mario Stipčević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>WEAVE</proposal_type><proposal_call>2024</proposal_call><code>WEAVE-2024-6226</code><acronim><![CDATA[SPARC-AI]]></acronim><duration>01.10.2025 - 30.09.2029</duration><status>U tijeku</status><financ_value>198.804,30 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, Interdisciplinarne prirodne znanosti, </scie_field_hr><scie_field_en>Physics, Interdisciplinary natural sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>4470, 864876, 23031, </team_members_id><team_members_names><![CDATA[Andrea Knežević, Anton Radman, Denis Abramović, ]]></team_members_names><keywords_hr><![CDATA[bio-inspirirani kompjuter sa slučajnim impulsima, jednofotonska lavinska dioda, brojanje fotona, obrada slika, detektor fotona, kvantna slučajnost]]></keywords_hr><keywords_en><![CDATA[bio-inspired random pulse computer, single-photon avalanche diode, photon counting, image processing, single-photon detector, quantum randomness]]></keywords_en><summary_hr><![CDATA[Danas se računalstvo gotovo isključivo izvodi putem paradigme digitalnog računanja (DC) temeljene na teoretskom modelu Turingovog stroja. Također, paradigma kvantnog računanja (QC) nedavno je počela dobivati na zamahu. Radikalno drugačija paradigma &#39;&#39;Random Pulse Computing&#39;&#39; (RPC), prvobitno predložena 60-ih godina, koristi brojanje i kombiniranje električnih impulsa koji se pojavljuju nasumično u vremenu, slično živčanim impulsima, a inspirirana je obradom informacija u neuronima živih bića. U posljednjem desetljeću, RPC je privukao veliku pozornost zbog ekonomične upotrebe resursa, otpornosti na pogreške, male potrošnje energije, te opet obećanja da će moći učinkovito riješiti probleme umjetne inteligencije koji su teški za DC i QC, kao što su: obrada slike, detekcija rubova (edge detection), duboko učenje i rješavanje problema na način koji oponaša rad ljudskog mozga. Ovdje predlažemo istraživanje koje vodi ka općoj teoriji sinteze sklopova za univerzalno RPC računalo na temelju pojma entropije. Na temelju toga, demonstrirat ćemo programibilno računalo sa slučajnim impulsima te njegovu primjenu na obradu slike, a sve na čipu izgrađenom korištenjem standardnog Si CMOS procesa i kvantne slučajnosti detekcije pojedinačnih fotona. Nadogradit ćemo naš nedavno objavljen znanstveni radovi o Kriteriju entropijskog budžeta (EBC) i slučajnom flip-flopu, koji zajedno predstavljaju moćan alat za sintezu novih RPC sklopova. Uzbuđeni smo činjenicom da se biološki nadahnuto računanje događa prirodno u tehnologiji kamera s pikselima koji broje fotone, što je uspješna tema istraživanja u AquaLabu na EPFL-u, gdje zapravo svaki svjetlosni senzor (piksel) kodira informacije u nasumičnom nizu impulsa kvantnog porijekla. Informacije u tom obliku mogu se izravno obraditi RPC sklopovima, što je glavna tema istraživanja u RBI-ju. U međusobnoj suradnji, nedavno smo napravili i prvi čipu koji sadrži čak 2800 RFF-ova. Ta nova tehnologija je ključan preduvjet za ovaj projekt. ]]></summary_hr><summary_en><![CDATA[Today, computing is almost exclusively done via the Digital Computation paradigm (DC) based on Turing machine theoretical model. Also, Quantum Computation (QC) paradigm has recently started to gain momentum. A radically different &#39;&#39;Random Pulse Computing&#39;&#39; (RPC) paradigm, whose principle was initially proposed in the 60&#39;s, makes use of counting and combining electrical pulses that appear randomly in time, similar to nerve pulses and inspired by information processing in neurons of living beings. Revisited in the past decade, RPC has attracted high attention because of it economic use of resources, fault tolerant computing, low power operation and yet a promise to be able to efficiently solve artificial intelligence problems that are hard for both DC and QC, such as: image processing, deep learning and problem-solving that mimic human brain operation. We propose a research towards a general theory of synthesis of circuits for a universal RPC computer based on the notion of entropy. Based on that, we will demonstrate a programmable Random Pulse Computer, and a use-case in image processing, built on a chip using standard Si CMOS process and quantum randomness of single-photon detection. We will build upon our recently published works on Entropy Budget Criterion (EBC) and random flip-flop, which together present a powerful tool for synthesis of novel RPC circuits. We are excited by the fact that bio-inspired sensing occurs naturally in the technology of single-photon counting camera, a successful research topic at AquaLab at EPFL, where indeed each light sensor (pixel) encodes information in a random pulse train of quantum origin. Information in that form can be processed directly by RPC circuits, a major research topic at RBI. In mutual collaboration, we have recently built a World&#39;s first random flip-flop on a chip carrying 2800 T-type RFFs. This new technology is a crucial asset for reaching the goals of this project. ]]></summary_en></project><project>
<id>17325</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Ante Pilipović]]></title_hr><title_en><![CDATA[]]></title_en><user_id>864977</user_id><user_firstLast_name>Ante Pilipović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-7111</code><acronim><![CDATA[]]></acronim><duration>07.04.2025 - 31.05.2025</duration><status>U tijeku</status><financ_value>4.675,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Temeljne tehničke znanosti, </scie_field_hr><scie_field_en>Basic engineering sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Građevinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Civil Engineering]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>17327</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Kristian Nakić]]></title_hr><title_en><![CDATA[]]></title_en><user_id>868564</user_id><user_firstLast_name>Kristian Nakić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-6241</code><acronim><![CDATA[]]></acronim><duration>01.05.2025 - 31.07.2025</duration><status>U tijeku</status><financ_value>7.820,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Science]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>17330</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Emanuel Gaši]]></title_hr><title_en><![CDATA[]]></title_en><user_id>865019</user_id><user_firstLast_name>Emanuel Gaši</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-6136</code><acronim><![CDATA[]]></acronim><duration>14.04.2025 - 19.05.2025</duration><status>U tijeku</status><financ_value>3.060,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut za jadranske kulture i melioraciju krša]]></institution_hr><institution_en><![CDATA[Institute for Adriatic Crops and Karst Reclamation in Split]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>17331</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Lucija Bukvić]]></title_hr><title_en><![CDATA[]]></title_en><user_id>869911</user_id><user_firstLast_name>Lucija Bukvić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-3222</code><acronim><![CDATA[]]></acronim><duration>01.04.2025 - 16.05.2025</duration><status>U tijeku</status><financ_value>3.910,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Tehnologija prometa i transport, </scie_field_hr><scie_field_en>Transport technology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet prometnih znanosti]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Transport and Traffic Sciences]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>17332</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Antonija Matek]]></title_hr><title_en><![CDATA[]]></title_en><user_id>865208</user_id><user_firstLast_name>Antonija Matek</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-5251</code><acronim><![CDATA[]]></acronim><duration>24.03.2025 - 24.04.2025</duration><status>U tijeku</status><financ_value>2.720,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>17334</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Andrija Poleksić]]></title_hr><title_en><![CDATA[]]></title_en><user_id>867559</user_id><user_firstLast_name>Andrija Poleksić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-8884</code><acronim><![CDATA[]]></acronim><duration>05.05.2025 - 25.07.2025</duration><status>U tijeku</status><financ_value>6.970,00 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Informacijske znanosti, </scie_field_hr><scie_field_en>Information sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci]]></institution_hr><institution_en><![CDATA[University of Rijeka]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>17335</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Tomislav Kardum]]></title_hr><title_en><![CDATA[]]></title_en><user_id>869924</user_id><user_firstLast_name>Tomislav Kardum</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-8467</code><acronim><![CDATA[]]></acronim><duration>01.04.2025 - 31.05.2025</duration><status>U tijeku</status><financ_value>5.185,00 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Povijest, </scie_field_hr><scie_field_en>History, </scie_field_en><institution_hr><![CDATA[Hrvatski institut za povijest]]></institution_hr><institution_en><![CDATA[Croatian Institute of History]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>17336</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Filip Pozar Požar]]></title_hr><title_en><![CDATA[]]></title_en><user_id>866805</user_id><user_firstLast_name>Filip Pozar Požar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-8742</code><acronim><![CDATA[]]></acronim><duration>01.06.2025 - 31.10.2025</duration><status>U tijeku</status><financ_value>13.005,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>17337</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Josip Hrvatić]]></title_hr><title_en><![CDATA[]]></title_en><user_id>867683</user_id><user_firstLast_name>Josip Hrvatić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-1584</code><acronim><![CDATA[]]></acronim><duration>01.05.2025 - 15.08.2025</duration><status>U tijeku</status><financ_value>9.095,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>17339</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Kristijan Vuraić]]></title_hr><title_en><![CDATA[]]></title_en><user_id>869605</user_id><user_firstLast_name>Kristijan Vuraić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-6419</code><acronim><![CDATA[]]></acronim><duration>28.04.2025 - 31.07.2025</duration><status>U tijeku</status><financ_value>8.075,00 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Biotehnologija, </scie_field_hr><scie_field_en>Biotechnology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Food Technology and Biotechnology]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>17341</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Jakov Ratković]]></title_hr><title_en><![CDATA[]]></title_en><user_id>29629</user_id><user_firstLast_name>Jakov Ratković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-7063</code><acronim><![CDATA[]]></acronim><duration>22.04.2025 - 30.05.2025</duration><status>U tijeku</status><financ_value>3.315,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Zrakoplovstvo, raketna i svemirska tehnika, </scie_field_hr><scie_field_en>Aerospace, missile and space engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>17342</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Jana Dukić]]></title_hr><title_en><![CDATA[]]></title_en><user_id>867965</user_id><user_firstLast_name>Jana Dukić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-1887</code><acronim><![CDATA[]]></acronim><duration>23.04.2025 - 30.05.2025</duration><status>U tijeku</status><financ_value>3.230,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera Osijek, Fakultet elektrotehnike, računarstva i informacijskih tehnologija Osijek]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Electrical Engineering, Computer Science and Information Technology Osijek]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>17343</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Tin Škugor]]></title_hr><title_en><![CDATA[]]></title_en><user_id>869699</user_id><user_firstLast_name>Tin Škugor</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-9459</code><acronim><![CDATA[]]></acronim><duration>01.05.2025 - 15.06.2025</duration><status>U tijeku</status><financ_value>3.910,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Food Technology and Biotechnology]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>17344</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Dajana Ćosić]]></title_hr><title_en><![CDATA[]]></title_en><user_id>867775</user_id><user_firstLast_name>Dajana Ćosić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-4593</code><acronim><![CDATA[]]></acronim><duration>08.09.2025 - 08.12.2025</duration><status>U tijeku</status><financ_value>7.820,00 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filologija, </scie_field_hr><scie_field_en>Philology, </scie_field_en><institution_hr><![CDATA[Staroslavenski institut]]></institution_hr><institution_en><![CDATA[Old Church Slavonic Institute in Zagreb]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>17345</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Eta Krpanec]]></title_hr><title_en><![CDATA[]]></title_en><user_id>865054</user_id><user_firstLast_name>Eta Krpanec</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-1540</code><acronim><![CDATA[]]></acronim><duration>25.04.2025 - 31.05.2025</duration><status>U tijeku</status><financ_value>3.145,00 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Psihologija, </scie_field_hr><scie_field_en>Psychology, </scie_field_en><institution_hr><![CDATA[Institut društvenih znanosti Ivo Pilar]]></institution_hr><institution_en><![CDATA[Institute of Social Sciences Ivo Pilar in Zagreb]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>17346</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Damjan Jurković]]></title_hr><title_en><![CDATA[]]></title_en><user_id>866591</user_id><user_firstLast_name>Damjan Jurković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-8392</code><acronim><![CDATA[]]></acronim><duration>23.04.2025 - 22.07.2025</duration><status>U tijeku</status><financ_value>7.735,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Temeljne tehničke znanosti, </scie_field_hr><scie_field_en>Basic engineering sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Građevinski fakultet u Rijeci]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Civil Engineering]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>17347</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Karlo Petrić]]></title_hr><title_en><![CDATA[]]></title_en><user_id>869917</user_id><user_firstLast_name>Karlo Petrić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-4160</code><acronim><![CDATA[]]></acronim><duration>24.03.2025 - 23.05.2025</duration><status>U tijeku</status><financ_value>5.185,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>17349</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Tomislav Javornik]]></title_hr><title_en><![CDATA[]]></title_en><user_id>865110</user_id><user_firstLast_name>Tomislav Javornik</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-8896</code><acronim><![CDATA[]]></acronim><duration>01.04.2025 - 30.06.2025</duration><status>U tijeku</status><financ_value>7.735,00 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Agronomski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Agriculture]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>17350</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Davor Marušić]]></title_hr><title_en><![CDATA[]]></title_en><user_id>866215</user_id><user_firstLast_name>Davor Marušić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-9802</code><acronim><![CDATA[]]></acronim><duration>31.03.2025 - 12.06.2025</duration><status>U tijeku</status><financ_value>6.290,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Građevinarstvo, </scie_field_hr><scie_field_en>Civil engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Građevinski fakultet u Rijeci]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Civil Engineering]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>17351</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Nina Karlović]]></title_hr><title_en><![CDATA[]]></title_en><user_id>869935</user_id><user_firstLast_name>Nina Karlović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-9688</code><acronim><![CDATA[]]></acronim><duration>15.09.2025 - 16.12.2025</duration><status>U tijeku</status><financ_value>7.905,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut za antropologiju]]></institution_hr><institution_en><![CDATA[Institute for Anthropological Research]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>17352</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Akshay Kumar Remeshan]]></title_hr><title_en><![CDATA[]]></title_en><user_id>866192</user_id><user_firstLast_name>Akshay Kumar Remeshan</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-6782</code><acronim><![CDATA[]]></acronim><duration>10.06.2025 - 08.08.2025</duration><status>U tijeku</status><financ_value>5.100,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Geodetski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Geodesy]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>17353</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Branka Mrduljaš]]></title_hr><title_en><![CDATA[]]></title_en><user_id>865113</user_id><user_firstLast_name>Branka Mrduljaš</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-4080</code><acronim><![CDATA[]]></acronim><duration>07.04.2025 - 09.05.2025</duration><status>U tijeku</status><financ_value>2.805,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Građevinarstvo, </scie_field_hr><scie_field_en>Civil engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Građevinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Civil Engineering]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>17355</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Marija Kuštro]]></title_hr><title_en><![CDATA[]]></title_en><user_id>869786</user_id><user_firstLast_name>Marija Kuštro</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-5500</code><acronim><![CDATA[]]></acronim><duration>21.05.2025 - 20.06.2025</duration><status>U tijeku</status><financ_value>2.635,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Interdisciplinarne prirodne znanosti, </scie_field_hr><scie_field_en>Interdisciplinary natural sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>17356</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Karla Orlić]]></title_hr><title_en><![CDATA[]]></title_en><user_id>865103</user_id><user_firstLast_name>Karla Orlić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-2579</code><acronim><![CDATA[]]></acronim><duration>17.03.2025 - 16.05.2025</duration><status>U tijeku</status><financ_value>5.185,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Interdisciplinarne prirodne znanosti, </scie_field_hr><scie_field_en>Interdisciplinary natural sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>17357</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Leonarda Vugrin]]></title_hr><title_en><![CDATA[]]></title_en><user_id>865094</user_id><user_firstLast_name>Leonarda Vugrin</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-4814</code><acronim><![CDATA[]]></acronim><duration>09.06.2025 - 10.07.2025</duration><status>U tijeku</status><financ_value>2.720,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>17358</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Ivana Zonjić]]></title_hr><title_en><![CDATA[]]></title_en><user_id>869797</user_id><user_firstLast_name>Ivana Zonjić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-3749</code><acronim><![CDATA[]]></acronim><duration>10.04.2025 - 09.06.2025</duration><status>U tijeku</status><financ_value>5.185,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Geofizika, </scie_field_hr><scie_field_en>Geophysics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>17359</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Ivan Martinović]]></title_hr><title_en><![CDATA[]]></title_en><user_id>867622</user_id><user_firstLast_name>Ivan Martinović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-4880</code><acronim><![CDATA[]]></acronim><duration>01.09.2025 - 28.02.2026</duration><status>U tijeku</status><financ_value>15.385,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>17444</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Ana-Marija Bogner]]></title_hr><title_en><![CDATA[]]></title_en><user_id>869875</user_id><user_firstLast_name>Ana-Marija Bogner</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-8823</code><acronim><![CDATA[]]></acronim><duration>01.09.2025 - 26.02.2026</duration><status>U tijeku</status><financ_value>15.215,00 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>17490</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Magdalena Brener]]></title_hr><title_en><![CDATA[]]></title_en><user_id>866695</user_id><user_firstLast_name>Magdalena Brener</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-6723</code><acronim><![CDATA[]]></acronim><duration>07.07.2025 - 07.09.2025</duration><status>U tijeku</status><financ_value>5.355,00 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Šumarstvo, </scie_field_hr><scie_field_en>Forestry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet šumarstva i drvne tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Forestry and Wood Technology]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>17500</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Dorian Loknar]]></title_hr><title_en><![CDATA[]]></title_en><user_id>869688</user_id><user_firstLast_name>Dorian Loknar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-8690</code><acronim><![CDATA[]]></acronim><duration>20.10.2025 - 21.11.2025</duration><status>U tijeku</status><financ_value>2.805,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>17545</id><title_hr><![CDATA[Svrhovito poslovanje: usklađivanjem osobne i organizacijske svrhe do nove teorije menadžmenta]]></title_hr><title_en><![CDATA[Purpose-Driven Business: Harmonizing Personal and Organizational Purpose towards a New Management Theory]]></title_en><user_id>870424</user_id><user_firstLast_name>Ivan Malbašić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2025-02</proposal_call><code>UIP-2025-02-5231</code><acronim><![CDATA[SPOJ]]></acronim><duration>19.02.2026 - 18.02.2031</duration><status>U tijeku</status><financ_value>246.100,00 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, </scie_field_hr><scie_field_en>Economy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet organizacije i informatike]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Organization and Informatics]]></institution_en><team_members_id>870426, 870433, 870427, 20231, 870796, </team_members_id><team_members_names><![CDATA[Nikolina Dreven, Larisa Hrustek, Lorena Pikl, Martina Tomičić Furjan, Gianluca Gionfriddo, ]]></team_members_names><keywords_hr><![CDATA[Svrhovito poslovanje, Usklađivanje svrhe, Upravljanje pomoću misija (MBM), Organizacijske vrijednosti, Mjerenje svrhovitosti, Održivost]]></keywords_hr><keywords_en><![CDATA[Purpose-driven business, Harmonization of purpose, Management by Missions (MBM), Organizational values, Measurement of purposefulness, Sustainability]]></keywords_en><summary_hr><![CDATA[Projekt istražuje i promovira koncept svrhovitih organizacija koje se baziraju na usklađivanju osobne i organizacijske svrhe, s konačnim ciljem pružanja odgovora na suvremena pitanja svrhovitog, održivog te ujedno uspješnog poslovanja. U skladu s ovom novom menadžerskom logikom svrhe, kroz projekt će se razviti teorijski okvir svrhovitih organizacija. Također, analizirat će se primjena upravljanja pomoću misija (MBM) kao alata za postizanje usklađenosti osobne i organizacijske svrhe, dugoročnog poslovnog uspjeha i stvaranja pozitivnog društvenog utjecaja, te će se identificirati njegovi nedostaci i predložiti rješenja za nadogradnju. Bit će razvijen instrument za mjerenje razine svrhovitosti poslovanja/organizacija. Projekt će analizirati i ulogu lidera i organizacijskih vrijednosti u izgradnji svrhovitih organizacija te će uključivati studije slučaja uspješnih poduzeća iz međunarodnog okruženja koja su prepoznata po visokoj razini svrhovitosti. Zaključno, projekt će stvoriti čvrstu teorijsku osnovu za implementaciju svrhovitog poslovanja u svakodnevnu praksu i doprinijeti razvoju nove teorije menadžmenta temeljene na svrsi.]]></summary_hr><summary_en><![CDATA[The project explores and promotes the concept of purpose-driven organizations based on aligning personal and organizational purposes. The ultimate goal is to address contemporary challenges related to purposeful, sustainable, and simultaneously successful business operations. The project will develop a theoretical framework for purpose-driven organizations in line with this new managerial logic of purpose. Additionally, the application of Management by Missions (MBM) as a tool for achieving alignment between personal and organizational purpose, long-term business success, and creating a positive social impact will be analyzed, along with identifying its shortcomings and proposing solutions for its enhancement. An instrument for measuring the level of purposefulness in business organizations will be developed. The project will also examine the role of leaders and organizational values in building purpose-driven organizations. It will include case studies of successful companies from international environments recognized for their high level of purposefulness. Ultimately, the project will establish a solid theoretical foundation for implementing purpose-driven business practices in everyday operations and contribute to the development of a new management theory based on purpose.]]></summary_en></project><project>
<id>17546</id><title_hr><![CDATA[Molekularni mehanizam aktivacije dsRNA senzora i njihove ADAR1-posredovane inhibicije kod HSV-1 infekcije]]></title_hr><title_en><![CDATA[The molecular mechanisms of dsRNA sensor activation and ADAR1-mediated suppression in HSV-1 infection]]></title_en><user_id>43</user_id><user_firstLast_name>Igor Jurak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-3026</code><acronim><![CDATA[HSVdsRNA-IJ ]]></acronim><duration>15.12.2025 - 14.12.2028</duration><status>U tijeku</status><financ_value>196.535,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, Interdisciplinarne prirodne znanosti, </scie_field_hr><scie_field_en>Biology, Interdisciplinary natural sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Fakultet biotehnologije i razvoja lijekova]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Biotechnology and Drug Development]]></institution_en><team_members_id>865076, 870054, 867717, 868162, 54, </team_members_id><team_members_names><![CDATA[Adwait Anand Parchure, Saman Taj, Umberto Rosani, Antonija Braut, Oliver Vugrek, ]]></team_members_names><keywords_hr><![CDATA[herpesvirus, RNA editing, ADAR1, PKR, herpes simpleks virus 1]]></keywords_hr><keywords_en><![CDATA[herpesvirus, RNA editing, ADAR1, PKR, herpes simplex virus 1]]></keywords_en><summary_hr><![CDATA[ADAR1 katalizira deaminaciju adenozina u inozine u dsRNA (uređivanje A-to-I) kako bi stanica razlikovala vlastite transkripte od virusnih te pritom prevenitaralo endogenu dsRNA od aktiviranja dsRNA senzora kao što su PKR, MDA5 i ZBP1 i pokretanja štetnih učinaka imunosti. Senzori dsRNA neophodni su za prepoznavanje virusnih dsRNA, koje generiraju svi RNA virusi, ali i dsDNA virusi. Zaštitnu ulogu ADAR1 stoga iskorištavaju virusi kako bi omogućili učinkovitu virusnu infekciju.       Nedavno smo otkrili da je ADAR1 potreban za sprječavanje aktivacije PKR-a da izazove translacijski zastoj tijekom produktivne HSV-1 infekcije. Međutim, točan mehanizam ove supresije posredovane s ADAR1 nije poznat. U ovoj studiji, cilj nam je sveobuhvatno karakterizirati virusni dsRNAom i editom kako bismo otkrili način aktivacije PKR i drugih senzora tijekom HSV-1 infekcije te doprinos A-to-I uređivanja tim procesima. Osim toga, cilj nam je definirati mjesta vezanja dsRNA za ADAR1 i PKR kako bismo bolje razumjeli molekularni mehanizam njihove interakcije. Naši preliminarni podaci ukazuju da ADAR1 inhibira PKR putem kompetitivnog vezanja za RNA te izravnom interakcijom koja sprječava dimerizaciju PKR-a. Molekularnim modeliranjem predvidjeli smo njihova mjesta kontakta te ćemo pomoću mutageneze i testova interakcije definirati ovu interakciju što će nam nadalje, zajedno s sekvenciranjem, omogućiti modeliranje točnog molekularnog mehanizma ADAR1 supresije PKR. Osim toga, istražit ćemo doprinos različitih virusnih proteina (vhs, ICP6, US11, ICP34.5) u supresiji prepoznavanja i signalizacije dsRNA.         Naša će insraživanje pridonijeti boljem razumijevanju temelja intrinzične imunosti, pružiti uvid u specifičnost i selektivnost različitih dsRNA senzora i otkriti molekularni mehanizam prethodno neprepoznatih interakcija domaćin-patogen. Nadalje, naše istraživanje interakcije ADAR1-PKR moglo bi dovesti do razvoja novih inhibitora koji bi se mogli koristiti u zaraznim bolestima i raku.]]></summary_hr><summary_en><![CDATA[ADAR1 catalyzes the deamination of adenosines to inosines in dsRNAs (A-to-I editing) to distinguish self from non-self transcripts and to protect endogenous dsRNA from activating dsRNA sensors such as PKR and MDA5 and triggering deleterious effects of innate immunity. dsRNA sensors are essential for the recognition of viral dsRNAs, which are inevitably produced by all RNA viruses, but also by dsDNA viruses. The protective role of ADAR1 is therefore exploited by viruses to enable efficient viral infection. We have recently found that ADAR1 is required to prevent PKR activation from triggering translational arrest during productive HSV-1 infection. However, the exact mechanism of this ADAR1-mediated suppression is not known. In this study, we aim to comprehensively characterize the viral dsRNAome and editome to uncover the activation of PKR and other sensors during HSV-1 infection and the contribution of A-to-I editing to these processes. In addition, we aim to define dsRNA binding sites for ADAR1 and PKR to better understand the molecular mechanism of their interaction. Our preliminary data suggest that ADAR1 represses PKR through competitive bidding on RNAs and direct interaction. We have predicted their interaction sites in silico and will now use mutagenesis and interaction assays to define this interaction. Together with the sequencing approach, this will allow us to model the exact molecular mechanism of ADAR1 suppression of PKR. In addition, we will investigate the contribution of different viral proteins (vhs, ICP6, US11, ICP34.5) in the suppression of dsRNA recognition and signaling. Our study will contribute to a better understanding of intrinsic immunity, provide insights into the specificity of dsRNA sensors and reveal the molecular mechanism of previously unrecognized host-pathogen interactions. In addition, our study of the ADAR1-PKR interaction could lead to the development of novel inhibitors that could be used in infectious diseases and cancer.]]></summary_en></project><project>
<id>17550</id><title_hr><![CDATA[Primjena tekuće biopsije u dijagnozi i praćenju akutne mijeloične leukemije]]></title_hr><title_en><![CDATA[Application of liquid biopsy in the diagnosis and monitoring of acute myeloid leukemia]]></title_en><user_id>3517</user_id><user_firstLast_name>Marija Grdić Rajković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-5566</code><acronim><![CDATA[AMLMolProfil]]></acronim><duration>01.12.2025 - 30.11.2028</duration><status>U tijeku</status><financ_value>199.895,00 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Clinical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Farmaceutsko-biokemijski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Pharmacy and Biochemistry]]></institution_en><team_members_id>869963, 6134, 21314, 865528, 869988, 3520, 869960, 870187, 867591, 26543, 24296, 6758, 4057, 12345, 12546, 4042, </team_members_id><team_members_names><![CDATA[Tomislav Brblić, Ivana Ćelap, Andrea Čeri, Marija Fabijanec, Petar Gaćina, Andrea Hulina Tomašković, Iva Ivanko, Monika Kolundžić, Martha Koržinek, Sanja Kožaj, Ivana Lapić, Mirta Mikulić, Margareta Radić Antolic, Lada Rumora, Anita Somborac Bačura, Radovan Vrhovac, ]]></team_members_names><keywords_hr><![CDATA[akutna mijeloična leukemija, tekuća biopsija, cirkulirajuća tumorska DNA, mikroRNA, dugolančana nekodirajuća RNA]]></keywords_hr><keywords_en><![CDATA[acute myeloid leukaemia, liquid biopsy, circulating tumour DNA, microRNA, long non-coding RNA]]></keywords_en><summary_hr><![CDATA[Pacijenti s akutnom mijeloičnom leukemijom (AML) često su podvrgnuti invazivnom postupku aspiracije koštane srži  za potrebe postavljanja dijagnoze i  praćenje odgovora na terapiju. Tekuća biopsija predstavlja neinvazivan i lako ponovljiv medicinski postupak uzimanja uzorka, najčešće periferne krvi. Cirkulirajuća tumorska DNA (ctDNA) izdvojena iz plazme daje nam vrijedne genske i epigenske informacije o primarnom tumoru te se zato smatra personaliziranom metodom koja ima veliki potencijal za postavljanje dijagnoze i praćenje AML-a. Nadalje, sekvenciranje ctDNA može identificirati klinički relevantne mutacije koje nisu detektirane u koštanoj srži što može utjecati na procjenu minimalne ostatne bolesti i predviđanje relapsa bolesti. Uz citogenetičke i molekularne promijene, deregulacija mikroRNA (miRNA) ima važnu ulogu u razvoju AML-a. miRNA reguliraju niz unutarstaničnih putova koji su ključni za leukemogenezu, diferencijaciju, proliferaciju, epigensku regulaciju, funkciju i preživljenje matičnih stanica. Nadalje, dugolančana nekodirajuća RNA (lncRNA) regulirajući gensku ekspresiju na pretranslacijskoj, posttranslacijskoj i epigenskoj razini značajno utječe na razvoj AML-a, potiče zastoj u diferencijaciji, proliferaciju i rezistenciju na terapiju. Analizom ctDNA, miRNA i lncRNA iz uzorka plazme dobivene postupkom tekuće biopsije od pacijenata s AML-om želimo utvrditi jesu li ove molekule pogodne za postavljanje dijagnoze i praćenje odgovora na terapiju. Analize ctDNA, lncRNA i miRNA trenutno su u fokusu znanstvenog interesa te će ovo istraživanje unaprijediti postojeća znanja i pridonjeti kliničkoj primjeni u otkrivanju bolesti, odabiru primjerene terapije temeljem molekulskog poremećaja te učinkovitom praćenju uspjeha terapije, tijeka bolesti i otkrivanja ponovne pojave bolesti.]]></summary_hr><summary_en><![CDATA[Patients with acute myeloid leukaemia (AML) often undergo the invasive procedure of bone marrow aspiration, both for diagnostic purposes and for monitoring response to therapy. Liquid biopsy is a non-invasive and easily repeatable medical procedure for sample collection, most commonly peripheral blood. Circulating tumour DNA (ctDNA) extracted from plasma provides valuable genetic and epigenetic information regarding primary tumour and is therefore considered personalized method with great potential for AML diagnosis and monitoring. ctDNA sequencing can identify clinically relevant mutations that may not be detected in bone marrow samples, and this might influence the assessment of measurable residual disease and the prediction of disease relapse. In addition to cytogenetic and molecular alterations, microRNA (miRNA) dysregulation plays a crucial role in AML development. miRNAs regulate various intracellular pathways essential for leukemogenesis, differentiation, proliferation, epigenetic regulation, function and survival of stem cells. On the other hand, long non-coding RNAs (lncRNAs) regulate gene expression at pretranslational, posttranslational, and epigenetic levels, significantly impacting AML development by promoting block in differentiation, uncontrolled proliferation, and therapy resistance. We aim to determine whether ctDNA, miRNA, and lncRNA from plasma samples obtained through liquid biopsy are suitable for diagnosis and monitoring therapeutic response in AML patients. Analyses of ctDNA, lncRNA and miRNA are currently in focus of scientific investigation. This research has a potential to improve existing knowledge on the topic and contribute to their clinical application in AML diagnosis, selection of appropriate therapy based on the molecular alteration, and effective follow-up of therapeutic efficiency, disease progression, and disease recurrence.]]></summary_en></project><project>
<id>17564</id><title_hr><![CDATA[Istočnojadranske šavoljike (Ochthebius; Hydraenidae; Coleoptera): Integrativna taksonomija kroz filogenomski pristup]]></title_hr><title_en><![CDATA[Unraveling the Eastern-Adriatic minute moss beetles (Ochthebius; Hydraenidae; Coleoptera): A phylogenomic approach to integrative taxonomy]]></title_en><user_id>3003</user_id><user_firstLast_name>Branka Bruvo Mađarić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-1684</code><acronim><![CDATA[HydrA-PAInT]]></acronim><duration>08.12.2025 - 07.12.2028</duration><status>U tijeku</status><financ_value>198.145,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>1280, 4269, 183, 19167, 27422, 868221, 868219, 2781, 870514, 873076, 870706, 873087, </team_members_id><team_members_names><![CDATA[Željka Pezer Sakač, Martina Podnar Lešić, Đurđica Ugarković, Vlatka Mičetić Stanković, Edin Lugić, Manfred Jaech, Michaela Brojer, Martina Pavlek, Adrian Villastrigo, Dora Lazar, Denis Bucan, Tin Rožman, ]]></team_members_names><keywords_hr><![CDATA[kompleks vrsta, molekularna delineacija vrsta, ddRAD-seq, SNP, DNA barkodiranje, vodeni kornjaši, hipersalini okoliš, krš]]></keywords_hr><keywords_en><![CDATA[species complex, molecular species delineation, ddRAD-seq, SNP, DNA barcoding, water beetles, hypersaline environment, karst]]></keywords_en><summary_hr><![CDATA[Rod Ochthebius (Hydraenidae, Coleoptera) obuhvaća brojne komplekse vrsta zabilježene u području zapadnog i srednjeg Sredozemlja, s vrlo složenom taksonomijom. Mnoge od ovih vrsta su lokalni endemi i stoga od posebnog značaja za očuvanje. Međutim, istočnojadranska regija do sada nije bila uključena u integrativno-taksonomska istraživanja porodice Hydraenidae, unatoč tome što je poznata kao žarište bioraznolikosti za brojne svojte slatkovodnih beskralješnjaka.U okviru ovog projekta uspostavit će se komparativna zbirka jedinki roda Ochthebius prikupljenih na specifičnim hiperslanim staništima na kopnu i otocima. Jedinke će biti identificirane na temelju standardnih morfoloških obilježja te usporedbom s jedinkama pohranjenim u zbirkama prirodoslovnih muzeja. Skupovi multilokusnih i filogenomskih SNP podataka bit će razvijeni korištenjem molekularnih metoda, te će se koristiti u razgraničenju vrsta unutar kompleksa vrsta i u filogenomskim analizama, u svrhu postavljanja filogenetskih i populacijsko-genetičkih hipoteza i evolucijskih scenarija za istočnojadranske svojte roda Ochthebius. Upotrebom integrativno-taksonomskog pristupa biti će provedena detaljna taksonomska revizija istočnojadranskih skupina vrsta roda Ochthebius. Rezultati će doprinijeti općem poznavanju sistematike i taksonomije porodice Hydraenidae u istočnojadranskom području, uz moguće nalaze kriptičnih taksona unutar pojedinih kompleksa vrsta. Novi taksonomski stručnjak će biti obučen u području taksonomije vodenih kornjaša. Upotreba novih filogenomskih metoda imat će značajan utjecaj na razvoj standardiziranih molekularnih protokola za identifikaciju vrsta unutar kompleksa vrsta vodenih kornjaša. Osim toga, rezultati će pružiti osnovu za praćenje bioraznolikosti i učinkovito očuvanje potencijalno ugroženih vodenih staništa i prateće faune beskralješnjaka u istočno-jadranskoj regiji - vrućoj točki biološke raznolikosti.]]></summary_hr><summary_en><![CDATA[Genus Ochthebius (Hydraenidae, Coleoptera) comprises numerous species complexes recorded in the Western and Central Mediterranean area, with highly complex taxonomy. Many of these species are local endemics and therefore of special conservation interest. However, Eastern-Adriatic region was not included in integrative taxonomic investigations of Hydraenidae so far, despite being known as a biodiversity hot-spot area for numerous freshwater invertebrate taxa. Within the project, a comparative collection of Ochthebius specimens, collected in specific hypersaline habitats on the mainland coast and islands, will be established. Specimens will be examined based on standard morphological characters, and compared to specimens deposited in water beetles collections of the natural history museums. Multilocus and genome-wide SNP marker sets will be developed. Generated molecular datasets will be used in the delineation of species complexes and in phylogenomic analyses, with the aim to establish phylogenetic and population-genetic hypotheses and evolutionary scenarios for Eastern-Adriatic Ochthebius taxa. A comprehensive taxonomic revision of specific groups within the genus will be carried out according to integrative-taxonomic approach. The results will greatly contribute to general knowledge about systematics and taxonomy of the family Hydraenidae in Eastern-Adriatic area, possibly resulting with discovery of cryptic taxa within the particular species complexes. New taxonomist will be trained. The utilization of the advanced phylogenomic methods will have great impact for the development of standardized molecular protocols for species identification within the species complexes of water beetles. In addition, the results will provide a basis for biodiversity monitoring and effective conservation of potentially endangered aquatic habitats and accompanying invertebrate fauna in the Eastern-Adriatic biodiversity hot-spot region. ]]></summary_en></project><project>
<id>17565</id><title_hr><![CDATA[Oblikovanje teritorijalne države u kasnosrednjovjekovnoj Hrvatskoj, Dalmaciji i Slavoniji: društveno-političke i administrativne mijene]]></title_hr><title_en><![CDATA[Building a Territorial State in Late Medieval Croatia, Dalmatia, and Slavonia: Political, Social, and Administrative Changes]]></title_en><user_id>2688</user_id><user_firstLast_name>Ivan Majnarić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-4345</code><acronim><![CDATA[CroDaSTrans]]></acronim><duration>03.12.2025 - 02.12.2028</duration><status>U tijeku</status><financ_value>138.050,00 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Povijest, </scie_field_hr><scie_field_en>History, </scie_field_en><institution_hr><![CDATA[Hrvatsko katoličko sveučilište, Zagreb]]></institution_hr><institution_en><![CDATA[Catholic University of Croatia]]></institution_en><team_members_id>1430, 867956, 5315, 25841, 330, 7383, 5122, 249, </team_members_id><team_members_names><![CDATA[Mladen Ančić, Francesco Bettarini, Eva Batorine Halasz, Neven Isailović, Zrinka Pešorda Vardić, Luka Špoljarić, Antun Nekić, Tomislav Popić, ]]></team_members_names><keywords_hr><![CDATA[Kasni srednji vijek, Kraljevina Hrvatska i Dalmacija, Kraljevina Slavonija, Zemlje Krune sv. Stjepana, Venecija, teritorijalna država]]></keywords_hr><keywords_en><![CDATA[Late Middle Ages, Kingdom of Croatia and Dalmatia, Kingdom of Slavonia, Lands of the Crown of Saint Stephen, Venice, territorial state ]]></keywords_en><summary_hr><![CDATA[Projekt razmatra duboke društvene i političke mijene u Kraljevini Hrvatskoj i Dalmaciji te Kraljevini Slavoniji u 14. i 15. stoljeću kroz prizmu oblikovanja teritorijalne države. Jedno od glavnih obilježja kasnosrednjovjekovnoga društvenoga, upravnog i političkog razvoja na području čitave Europe bio je porast opsega i dohvata vladareve/državne moći, odnosno rast infrastrukturne moći države. U tom se kontekstu razmatraju modaliteti kojima su vladari krune sv. Stjepana i Mletci upravljali i oblikovali područja u središtu zanimanja projekta. Historiografska tradicija te je državne tvorbe dominanto motrila kao takmace i suparnike, što doista jest bitan aspekt istraživanja, no projektni je cilj onkraj takvog pristupa usmjeren na druga dva podjednako bitna aspekta. Riječ je o uočavanju razlika i sličnosti u načinu administrativnoga i društvenog oblikovanja istih područja u okrilju različitih političkih sustava, a koje se ujedno, s obzirom na središe moći, može opisati kao politička periferija tih sustava. S tim na umu spomenute društvene i političke mijene postaju tim bitnije ukoliko se motre iz aspekta stasanja teritorijalne države, pri čemu osnovni istraživački postupci proizlaze iz komparativnog pristupa, temeljenog kako na sinkronijskoj, tako i dijakronijskoj perspektivi. Rezultati projekta u tom pogledu otvorit će mogućnost i širega europskog dijaloga o strukturama kasnosrednjovjekovnih političkih tvorbi, ali i o strategijama i suptilnim procesima društvenog pregovaranja pojedinaca i lokalnih zajednica pred sve većim pritiskom infrastrukturne moći države.]]></summary_hr><summary_en><![CDATA[The project examines the profound social and political transformations in the Kingdom of Croatia and Dalmatia, as well as the Kingdom of Slavonia, during the 14th and 15th centuries through the lens of territorial state formation. A key feature of late medieval development across Europe was the expanding scope and influence of sovereign and state power, particularly in terms of infrastructural capacity. In this context, the project explores how the rulers of the Crown of St. Stephen and the Venetians governed and shaped these regions. While historiography has traditionally framed these authorities as competitors and rivals—an important aspect of the study—this project moves beyond that narrative to explore two equally significant dimensions. The first examines the differences in administrative and social structures under various political systems within the same region. The second considers potential parallels in the administrative and social organization of regions that, relative to centers of power, functioned as political peripheries. By analyzing these social and political transformations from the perspective of territorial state formation, their significance becomes even more pronounced. The research adopts a comparative methodology, incorporating both synchronic and diachronic analyses. The project&#39;s findings may contribute to a broader European discourse on the structures of late medieval political entities and the complex strategies and processes of social negotiation employed by individuals and local communities in response to the growing infrastructural power of the state.]]></summary_en></project><project>
<id>17566</id><title_hr><![CDATA[CHLOCK: Uloga gena cirkadijanog ritma u razvoju klasičnog Hodgkinovog limfoma]]></title_hr><title_en><![CDATA[CHLOCK: The role of circadian rhythm genes in the development of classic Hodgkin&#39;s lymphoma]]></title_en><user_id>1497</user_id><user_firstLast_name>Petra Korać</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-4581</code><acronim><![CDATA[CHLOCK]]></acronim><duration>20.12.2025 - 19.12.2028</duration><status>U tijeku</status><financ_value>198.950,00 eur</financ_value><scie_area_hr>Prirodne znanosti, Biomedicina i zdravstvo, </scie_area_hr><scie_area_en>Natural sciences, Biomedicine and health sciences, </scie_area_en><scie_field_hr>Biologija, Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Biology, Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>3204, 865709, 25798, 4080, 3450, </team_members_id><team_members_names><![CDATA[Slavko Gašparov, Suzana Hančić, Valerija Begić, Snježana Židovec Lepej, Snježana Dotlić, ]]></team_members_names><keywords_hr><![CDATA[cirkadijani ritam, transkriptomika, klasični Hodgkinov limfom, uzorci pacijenata, stanične linije]]></keywords_hr><keywords_en><![CDATA[circadian rhythm, transcriptomics, classic Hodgkin&#39;s lymphoma, patient samples, cell lines]]></keywords_en><summary_hr><![CDATA[Cirkadijani sustav se sastoji od centralnog sata u suprahijazmatskoj jezgri hipotalamusa i perifernih satova u gotovo svakoj stanici u tijelu. Sustav molekularnih satova usklađuje fiziologiju organizma s izmjenom dana i noći. Osnovne komponente cirkadijanih satova su proteini CLOCK, BMAL1, PER i CRY koji čine transkripcijsko-translaciju petlju kojom reguliraju vlastitu aktivnost, ali i aktivnost mnoštva drugih gena na koje djeluju kao transkripcijski faktori, represori ili modulatori kromatina. Iako se promjene cirkadijanih gena povezuju s razvojem limfoma još se uvijek ne zna njihova točna uloga i potencijal u prevenciji/liječenju ove skupine bolesti. Cilj ovog projekta je istražiti ulogu gena cirkadijanog ritma u razvoju klasičnog Hodgkinovog limfoma (HL) na način da se utvrde specifične promjene u staničnom transkriptomu koje aberacije tih gena uzrokuju i da se definiraju narušeni signalni putovi u tumorskim stanicama. Hodgkinov limfom je biološki raznolika skupina limfoidnih tumora sličnih morfologija i imunofenotipa koja čini 1% svih de novo neoplazmi svjetske populacije i jedna je od najčešćih bolesti među mlađom populacijom odraslih (20-40 godina). Kako bi se dobili reprezentativni podaci o promjenama u tumorskim stanicama HL-a, projekt se sastoji od dva dijela: inovativne metode prostorne transkriptomike na uzorcima pacijenata koja omogućava analizu u visokospecifičnom tumorskom tkivu HL-a gdje su tumorske stanice raspršene u mnogobrojnim stanicama upalnog infiltrata i manipulacije ekspresije cirkadijanih gena u staničnim linijama HL-a kako bi se detaljno i precizno utvrdile promjene koje su posljedica aberantne ekspresije cirkadijanih gena. Projektni tim obuhvaća stručnjake iz 4 institucije, iz područja molekularne biologije, patologije, medicinske genetike i transkriptomike. Očekuje se da će rezultati pridonijeti temeljnom razumijevanju utjecaja cirkadijanog ritma na razvoj malignih bolesti što bi posljedično moglo imati i javnozdravstveni značaj.]]></summary_hr><summary_en><![CDATA[The circadian system consists of a central clock in the suprachiasmatic nucleus of the hypothalamus and peripheral clocks in almost every cell in the body. The system of molecular clocks harmonizes the organism&#39;s physiology with the day/night exchange. The basic components of circadian clocks are the proteins CLOCK, BMAL1, PER and CRY, which form a transcription-translation loop by which they regulate their own activity, but also the activity of other genes e. g. transcription factors, repressors, chromatin modulators. Although changes in circadian genes are associated with the development of lymphoma, their role in the prevention/treatment of this diseases is still unknown. The goal of this project is to investigate the role of circadian rhythm genes in the development of Hodgkin&#39;s lymphoma (HL): to determine specific changes in the tumor transcriptome that their aberrations cause and define impaired signalling pathways. HL is a biologically diverse group of lymphoid tumours with similar morphologies/immunophenotypes that make up 1% of all de novo neoplasms in the world and are one of the most common diseases among the younger adult population (20-40 yrs). In order to obtain representative data about changes in tumour cells, the project consists of two parts: innovative method of spatial transcriptomics on patient samples that enable analysis in highly specific HL tumor tissue where tumor cells are scattered in numerous cells of the inflammatory infiltrate and manipulation of circadian gene expression in HL cell lines in order to determine precise changes resulting from aberrant expression of circadian genes. The project team includes experts from 4 institutions: from the fields of molecular biology, pathology, medical genetics and transcriptomics. It is expected that the results will contribute to the fundamental understanding of the circadian rhythm in the development of Hodgkin&#39;s lymphoma, which could consequently have public health significance.]]></summary_en></project><project>
<id>17567</id><title_hr><![CDATA[Sinteza novih benzazolnih heterocikla kao potencijalnih antitumorskih i antibakterijskih agensa]]></title_hr><title_en><![CDATA[]]></title_en><user_id>2914</user_id><user_firstLast_name>Marijana Hranjec</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-3725</code><acronim><![CDATA[BenzHetPot ]]></acronim><duration>24.11.2025 - 23.11.2031</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet kemijskog inženjerstva i tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Chemical Engineering and Technology]]></institution_en><team_members_id>872903</team_members_id><team_members_names><![CDATA[ Doktorand: Jurja Vukovinski ]]></team_members_names><keywords_hr><![CDATA[benzazoli, heterocikli, zelena kemija, antitumorska aktivnost, antibakterijska aktivnost]]></keywords_hr><keywords_en><![CDATA[benzazoles, heterocycles, green chemistry, antitumor activity, antibacterial activity]]></keywords_en><summary_hr><![CDATA[Predloženi istraživački projekt usmjeren je na dizajn, sintezu i strukturnu karakterizaciju novih derivata benzazola kao potencijalnih agensa s antitumorskim i antibakterijskim djelovanjem. Projekt je izrazito multidisciplinaran i okuplja interdisciplinarni tim od 10 istraživača čija će zajednička sinergija dovesti do postizanja glavnih ciljeva projekta. Projekt će se sastojati od tri glavna cilja uključujući sintezu i strukturnu karakterizaciju derivata benzazola, optimiranje i razvoj novih zelenih sintetskih metoda te biološka ispitivanja. U sklopu projekta provest će se sinteza biblioteke različitih benzazola, a dodatno bi ovo zajedničko istraživanje trebalo rezultirati optimiranjem strukture benzazolne jezgre što će osigurati bolju učinkovitost, aktivnost, selektivnost i optimirana fizikalno-kemijska i biološka svojstva u potrazi za predvodnim spojevima. Strukturno optimiranje kao i proučavanje biološkog djelovanja provest će se i pomoću računalne kemija. Biološka ispitivanja uključivat će in vitro testove za procjenu antiproliferativne i antibakterijske aktivnosti. Odabranim najaktivnijim spojevima ispitat će se u dodatnim eksperimentima određivanja antitumorskog i/ili antibakterijskog djelovanja i mehanizmi njihovog biološkog djelovanja odabirom specifičnih bioloških meta. Kako bi se dobio bolji uvid u mehanizme djelovanja predvodnih spojeva, provodit će se i elektrokemijska ispitivanja biološkog djelovanja te interakcija s DNA/RNA. Na temelju principa suvremenog pristupa lijekovima, proučavat će se korelacija i sinergija između spojeva s obećavajućim antitumorskim i antibakterijskim djelovanjem. Konačno, opisano istraživanje temelji se na zajedničkom istraživanju nekoliko različitih institucija uključujući istraživače iz različitih znanstvenih područja. Predloženi projekt temelji se na istraživanjima u području medicinske kemije s naglaskom na moguća daljnja ciljana istraživanja kao i daljnji razvoj naše znanstvene grupe na međunarodnoj razini.]]></summary_hr><summary_en><![CDATA[The proposed research project is oriented towards the design, synthesis, and structural characterization of novel benzazoles as promising agents with antitumor and antibacterial activity. The project is highly multidisciplinary and brings together an interdisciplinary team of 10 researchers whose common synergy will lead to the achievement of the main project goals and objectives. The project will consist of three main objectives including synthesis and structural characterization of benzazole derivatives, optimization and development of novel green synthetic methods and biological evaluation. Within the project synthesis of benzazole library will be achieved, while this collaborative research should result in the optimization of the benzazole structural core which will ensure better efficiency, activity, selectivity, and optimized physico-chemical and biological properties in the search for lead compounds. Structural optimization and studying of the biological action will be aided by computational chemistry. Biological evaluation will include in vitro evaluation of antiproliferative and antibacterial activity. The chosen most active compounds will be evaluated in additional antitumor and antibacterial assays to study their mechanisms of biological action by choosing specific biological targets. To get more insight into the mechanisms of action of lead compounds, the electrochemical evaluation of the biological action and interaction with DNA/RNA will be studied. Based on the principles of modern drug approach, the correlation and synergy between compounds with promising antitumor and antibacterial activity will be studied. Finally, the presented research is based on joint research of different institutions including researchers from different scientific fields. Proposed project is based on the research in the field of medicinal chemistry with focus on possible further target research and further development of our scientific group on the international level.]]></summary_en></project><project>
<id>17568</id><title_hr><![CDATA[Dokumentarni obrat u europskoj književnosti nakon 1989. godine]]></title_hr><title_en><![CDATA[The Documentary Turn in Post-1989 European Literature]]></title_en><user_id>3595</user_id><user_firstLast_name>Danijela Lugarić Vukas</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-7801</code><acronim><![CDATA[DOKUOB/DOCTURN]]></acronim><duration>12.12.2025 - 11.12.2028</duration><status>U tijeku</status><financ_value>125.235,00 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filologija, Interdisciplinarne humanističke znanosti, </scie_field_hr><scie_field_en>Philology, Interdisciplinary humanities, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>3566, 29021, 20703, 11118, 19087, 19057, 5143, 19697, 870227, 870331, 870407, </team_members_id><team_members_names><![CDATA[Milka Car, Brigitte Obermayr, Stijn Vervaet, Maciej Czerwinski, Branimir Janković, Maša Kolanović, Jasmina Vojvodić, Natka Badurina, Matija Ivačić, Csongor Lorincz, Boris Previšić, ]]></team_members_names><keywords_hr><![CDATA[dokumentarizam, dokumentarna estetika, mimetički ugovor, referencijalnost, europska književnost nakon 1989. godine]]></keywords_hr><keywords_en><![CDATA[documentariness, documentary aesthetics, mimetic contract, referentiality, European literature post-1989]]></keywords_en><summary_hr><![CDATA[Cilj ovog projekta jest identificirati, proučiti i organizirati dokumentarne književne tekstove, objavljene od 1989. godine u različitim europskim književnostima, prije svega na postjugoslavenskom kulturnom prostoru i u susjednim kulturama – mađarskoj i talijanskoj, u književnosti njemačkog govornog područja, češkoj, poljskoj, ruskoj i rusofonoj. Kako bismo prevladali disparitet i nedostatke u postojećim znanstvenim istraživanjima koja se bave ovom temom, ispitat ćemo korpus književnih tekstova iz navedenih polja iz dvije temeljne, međusobno povezane teorijske perspektive: mimetičkog ugovora i referencijalnosti. Pitanje dokumentarne estetike u književnosti čini posebno područje u suvremenoj znanosti o književnosti, koja se često smatra jednom od središnjih književnih rasprava našeg vremena. Osim toga, ovim projektom tvrdimo da je uporaba dokumenta, shvaćenog ovdje kao objekt reprezentacije i umjetničko sredstvo, u temeljima najproduktivnijih tokova u suvremenoj književnosti, zbog čega zahtijeva temeljitu sistematizaciju i interpretaciju kroz zajednički rad skupine iskusnih istraživača iz znanstvenih institucija u Hrvatskoj i inozemstvu. Napuštajući i pojam objektivne istine u kontekstu promišljanja konstruktivnih načela književnoga teksta i binarnu opoziciju fakcije i fikcije, cilj ovog projekta je promišljanje tih, u književnom stvaralaštvu temeljnih kategorija kako bi se pomno ispitale različite manifestacije isprepletenosti tih dvaju diskursa, dokumentarnog i fikcionalnog, u različitim europskim književnostima u transnacionalnoj i interkulturalnoj perspektivi.]]></summary_hr><summary_en><![CDATA[This project aims to identify, study, and organize different genres of documentary literature that have been written and published since 1989 in different European literatures, most notably in post-Yugoslav and neighboring cultural spaces—Italian and Hungarian, in the German-speaking area, Czech, Polish, and Russian, and Russophone. To address the gaps in current research on this topic, we will look at a group of literary texts from the mentioned literatures using two main theoretical concepts: the mimetic contract and referentiality. We propose that the issue of documentary aesthetics in literature forms a specific area in contemporary humanities, often attributed to as one of the central literary debates of our time. In addition, we argue that the document, in this project understood as an object of representation and an artistic device, is the foundation of the most productive streams in contemporary literature, thereby asking for a thorough systematization and interpretation through a collective effort of a group of experienced researchers from scholarly institutions in Croatia and abroad. Abandoning both the concept of objective truth in relation to literary craft and the binary opposition of fact and fiction, this project seeks to reflect on the dimensions of factuality and the function of fiction in order to examine various manifestations of intertwining between fictional and non-fictional/factual modes of discourse in various European literatures in a transnational and cross-cultural context.]]></summary_en></project><project>
<id>17571</id><title_hr><![CDATA[Praćenje antimikrobne rezistencije analizom podzemnih voda]]></title_hr><title_en><![CDATA[]]></title_en><user_id>12566</user_id><user_firstLast_name>Nikolina Udiković Kolić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-5209</code><acronim><![CDATA[ARES]]></acronim><duration>20.01.2026 - 19.01.2031</duration><status>U tijeku</status><financ_value>60,00 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Biotehnologija, </scie_field_hr><scie_field_en>Biotechnology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>873058</team_members_id><team_members_names><![CDATA[ Doktorand: Josipa Pečnik ]]></team_members_names><keywords_hr><![CDATA[antimikrobna rezistencija, podzemne vode, patogeni, rezistentni geni, enterobakterije]]></keywords_hr><keywords_en><![CDATA[antimicrobial resistance, groundwaters, pathogens, antibiotic resistance genes, enterobacteria]]></keywords_en><summary_hr><![CDATA[Antimikrobna rezistencija (AMR) jedna je od najvećih prijetnji ljudskom zdravlju i zahtijeva integrirani pristup One Health za temeljito istraživanje i kontrolu. Međutim, nadzor AMR-a kod bakterija ograničen je na kliničko okruženje kako u Hrvatskoj tako i u svijetu, dok se malo pozornosti posvećuje okolišu. Unatoč važnoj ulozi podzemne vode kao izvora opskrbe pitkom vodom, njezin doprinos globalnoj AMR krizi još je uvelike neistražen. Kako bi popunio ovu prazninu, projekt ARES usvojit će holistički, interdisciplinarni pristup za istraživanje rezistoma, mikrobioma i mobiloma četiri izvorišta podzemne vode, uključujući tri krška izvorišta koji se koriste za vodoopskrbu u Hrvatskoj. Primijenit ćemo metode neovisne o uzgoju mikroorganizama kao što su qPCR čipovi u kombinaciji sa sekvenciranjem amplikona 16S rRNA gena kako bismo istražili rezistom i mikrobiom podzemne vode kroz različite sezone. To će nam omogućiti procjenu vremenskih trendova u raznolikosti i brojnosti mikrobioma i rezistoma u proučavanim izvorištima. Osim toga, koristit ćemo pristupe ovisne o uzgoju za procjenu AMR profila klinički važnih patogena (Escherichia coli, Klebsiella pneumoniae, Acinetobacter baumanii, Pseudomonas aeruginosa i Enterococcus spp.) koje ćemo izolirati iz podzemnih voda. Primjenom metode sekvenciranja cijelog genoma, istražit ćemo molekularne mehanizme rezistencije i potencijalnu patogenost ovih izolata. Naposljetku, hvatanje rezistentnih plazmida direktno iz bakterija podzemne vode u E. coli i njihovo naknadno potpuno sekvencioniranje bit će presudno za donošenje zaključaka o potencijalnoj razmjeni AMR-a između okolišnih rezervoara i ljudske populacije. Vjerujemo da će dobivena saznanja pružiti važne uvide za razvoj strategija upravljanja usmjerenih na smanjenje pojave i širenja AMR-a putem rezervoara pitke vode.]]></summary_hr><summary_en><![CDATA[Antimicrobial resistance (AMR) is one of the greatest threats to human health and requires a comprehensive One Health approach for thorough investigation and control. However, surveillance of AMR in bacteria is limited to the clinical setting both in Croatia and worldwide, while little attention is paid to the environment. Despite the important role of groundwater as a drinking water supply, its contribution to the global AMR crisis is still largely unexplored. To fill this gap, the ARES project will adopt a holistic, interdisciplinary approach to investigate the resistome, microbiome and mobilome of four groundwater sources, including three karst sources used for water supply in Croatia. We will apply culture-independent methods such as high-throughput qPCR arrays and standard qPCR in combination with 16S rRNA amplicon sequencing to investigate the resistome and microbiome of groundwater over several seasons. This will allow us to assess temporal trends in the diversity and abundance of the microbiome and resistome in the studied groundwater sources. In addition, we will use culture-dependent approaches to assess the AMR profile of clinically important pathogens (Escherichia coli, Klebsiella pneumoniae, Acinetobacter baumanii, Pseudomonas aeruginosa and Enterococcus spp.) isolated from groundwater and investigate the molecular mechanisms of their resistance and virulence potential using whole-genome sequencing. Finally, the direct capture of antibiotic-resistant plasmids from groundwater bacteria to E. coli and their subsequent complete sequencing will be crucial to draw conclusions on the potential exchange of AMR between environmental reservoirs and the community. We believe that this knowledge will provide important insights for management strategies aimed at mitigating the emergence and spread of AMR and important human pathogens via drinking water reservoirs.]]></summary_en></project><project>
<id>17578</id><title_hr><![CDATA[Neuroprotektivno djelovanje florotanina iz makroalgi Jadranskog mora u zebrici Danio rerio kao modelu Parkinsonove bolesti]]></title_hr><title_en><![CDATA[]]></title_en><user_id>13019</user_id><user_firstLast_name>Sanja Babić Brčić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-6039</code><acronim><![CDATA[NeuroFishAdria]]></acronim><duration>29.11.2025 - 28.11.2030</duration><status>U tijeku</status><financ_value>60,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>873024</team_members_id><team_members_names><![CDATA[ Doktorand: Matea Matković ]]></team_members_names><keywords_hr><![CDATA[smeđe makroalge, florotanini, bioaktivnost, Danio rerio, Parkinsonova bolest, biotestovi]]></keywords_hr><keywords_en><![CDATA[brown macroalgae, phlorotannins, bioactivity, Danio rerio, Parkinson&#39;s disease, bioassays]]></keywords_en><summary_hr><![CDATA[Više od 10 milijuna ljudi diljem svijeta boluje od Parkinsonove bolesti (PB), progresivnog neurodegenerativnog poremećaja karakteriziranog brojnim motoričkim i nemotoričkim simptomima. Trenutna terapija je simptomatska i često je popraćena sa značajnim nuspojavama. Unatoč brojnim pokušajima, još uvijek nije pronađen spoj/lijek koji može promijeniti tijek bolesti. Florotanini, polifenolni spojevi koji se nalaze u smeđim makroalgama, prepoznati su kao izvrsni kandidati za razvoj terapeutika nove generacije. Međutim, njihovo neuroprotektivno djelovanje još uvijek je nedovoljno istraženo. Cilj ovog projekta je ispitati neuroprotektivan potencijal florotanina iz smeđih makroalgi Jadranskog mora. Naš multidisciplinarni pristup kombinira in silico, in vitro i in vivo metodologije kako bi razjasnili mehanizam djelovanja florotanina u vidu zaštite neuralnih tkiva i potencijalnog ublažavanja/izlječenja PB-i. Korištenjem ličinaka i odraslih zebrica Danio rerio, moći ćemo sveobuhvatno ispitati napredovanje bolesti i simptoma povezanih s patologijom PB-i u različitim životnim fazama. Ovakav pristup omogućit će nam procjenu zaštitnih učinaka florotanina protiv motoričkih deficita, kao i biokemijskih i molekularnih promjena u mozgu zebrice karakterističnih za PB. Nadalje, pristup korišten unutar ovog projekta mogao bi predstavljati platformu za probir velikog broja prirodnih spojeva sa zaštitnim učinkom protiv PB-i i tako ubrzati otkriće i razvoj novih lijekova u budućnosti. Stvaranjem baze florotanina s neuroprotektivnim djelovanjem prisutnih u makroalgama Jadranskog mora, ovaj projekt otvorit će mogućnost suradnje s farmaceutskom industrijom i ubrzati razvoj terapeutika na bazi algi. Dobiveni rezultati mogli bi imati znanstvene i društvene implikacije, kako podizanjem osviještenosti o bolesti, tako i smanjenjem ekonomskih i zdravstvenih izdataka povezanih s PB-i.]]></summary_hr><summary_en><![CDATA[Over 10 million people worldwide suffer from Parkinson&#39;s disease (PD), a progressive neurodegenerative disorder characterized by motor and non-motor symptoms. Current treatments are primarily symptomatic and often come with significant side effects. To date, no therapy has been found that can halt or reverse the progression of PD. In this context, phlorotannins, polyphenols produced by brown macroalgae, have emerged as promising candidates for developing new-generation therapeutics. However, research on their neuroprotective effects is still in its infancy. This project investigates the neuroprotective effects of phlorotannins derived from brown macroalgae of the Adriatic Sea. Our multidisciplinary approach combines in silico, in vitro, and in vivo methodologies to elucidate the mechanism through which these compounds may protect neural tissues and potentially mitigate PD. By utilizing both larval and adult zebrafish Danio rerio we will be able to thoroughly examine PD&#39;s progression and pathology-related symptoms across different life stages. This comprehensive strategy will enable us to assess the protective effects of phlorotannins against motor deficits, as well as biochemical and molecular alterations in the PD-induced zebrafish model, providing valuable insights into potential treatments for neurodegenerative disorders. Additionally, such an approach will provide a screening platform for determining the anti-PD effect of myriad biomolecules, thus accelerating the discovery and development of algae-based therapeutics. By creating a library of phlorotannins with neuroprotective effects from the Adriatic Sea macroalgae, this project aims to foster collaborations with the pharmacological industry, potentially leading to breakthrough treatments for neurodegenerative diseases. The implications of our findings could significantly alleviate the societal and economic/healthcare burdens associated with PD by advancing understanding and treatment options.]]></summary_en></project><project>
<id>17579</id><title_hr><![CDATA[Primjena prigušene totalne refleksije (ATR) u akvakulturi i biotehnologiji]]></title_hr><title_en><![CDATA[Application of attenuated total reflectance (ATR) in aquaculture and biotehnology]]></title_en><user_id>865904</user_id><user_firstLast_name>Krunoslav Bojanić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2025-02</proposal_call><code>UIP-2025-02-2319</code><acronim><![CDATA[AquaATR]]></acronim><duration>19.02.2026 - 18.02.2031</duration><status>U tijeku</status><financ_value>299.901,25 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo, Biotehničke znanosti, Prirodne znanosti, Tehničke znanosti, Interdiciplinarne znanosti, </scie_area_hr><scie_area_en>Biomedicine and health sciences, Biotechnical sciences, Natural sciences, Technological sciences, Interdisciplinary scientific area, </scie_area_en><scie_field_hr>Biotehnologija u biomedicini, Fizika, Kemija, Biologija, Kemijsko inženjerstvo, Računarstvo, Javno zdravstvo i zdravstvena zaštita, Veterinarska medicina, Poljoprivreda, Biotehnologija, Interdisciplinarne prirodne znanosti, Interdisciplinarne tehničke znanosti, Interdisciplinarne biotehničke znanosti, Biotehnologija u biomedicini, </scie_field_hr><scie_field_en>Biotechnology in Biomedicine, Physics, Chemistry, Biology, Chemical engineering, Computer sciences, Public health and health services, Veterinary medicine, Agriculture, Biotechnology, Interdisciplinary natural sciences, Interdisciplinary technological sciences, Interdisciplinary biotechnical sciences, Biotechnology in Biomedicine, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>25383, 2762, 19451, </team_members_id><team_members_names><![CDATA[Ivana Giovanna Zupičić, Josip Barišić, Kristina Serec, ]]></team_members_names><keywords_hr><![CDATA[molekulska spektroskopija, bakterije, tjelesne tekućine, akvakultura, biotehnologija, identifikacija, dijagnostika, bioraznolikost, kemometrika, SEIRA]]></keywords_hr><keywords_en><![CDATA[molecular spectroscopy, bacteria, biofluids, aquaculture, biotechnology, identification, diagnostics, biodiversity, chemometrics, SEIRA]]></keywords_en><summary_hr><![CDATA[AquaATR je interdisciplinarni projekt koji istražuje primjenu infracrvene spektroskopije s Fourierovom transformacijom metodom prigušene totalne refleksije (ATR) u akvakulturi i biotehnologiji. Cilj projekta je razviti brze i pouzdane dijagnostičke metode za karakterizaciju bioloških uzoraka u akvatičnim sustavima, čime se doprinosi unapređenju dijagnostike bolesti, mikrobiološkim istraživanjima bioraznolikosti i biotehnološkim primjenama. Projekt će formirati novu istraživačku grupu s fokusom na sljedeće specifične ciljeve: i) identifikacija i subtipizacija patogena u akvakulturi ii) taksonomska dereplikacija bioraznolikosti kultivabilnog mikrobioma ribe iii) klinička dijagnostika analizom tjelesnih tekućina ribe iv) površinsko pojačavanje i optimizacija spektralnih podataka i analiza. U multidisciplinarnom pristupu koji će obuhvatiti znanstvene discipline molekulske spektroskopije, biotehnologije u biomedicini (posebice veterinarske medicine i sigurnosti hrane), opće i primijenjene mikrobiologije, molekularne biologije, biokemije, kemometrike i umjetne inteligencije.  Primjena ATR tehnologije u ovom kontekstu otvara nove mogućnosti u veterinarskoj medicini, sigurnosti hrane, bioprospectingu i istraživanju bioraznolikosti. Metode razvijene unutar projekta imat će široku znanstvenu i primijenjenu vrijednost, s potencijalom za implementaciju u različitim područjima znanosti i industrije.]]></summary_hr><summary_en><![CDATA[AquaATR is an interdisciplinary project to investigate the application of Fourier transform infrared spectroscopy using the attenuated total reflectance (ATR) method in aquaculture and biotechnology. The project aims to develop rapid and reliable diagnostic methods for the characterization of biological samples in aquatic systems, thereby contributing to the improvement of disease diagnostics, microbiological biodiversity research and biotechnological applications. The project will form a new research group with a focus on the following specific objectives: i) identification and subtyping of pathogens in aquaculture ii) taxonomic dereplication of the biodiversity of the cultivable fish microbiome iii) clinical diagnostics by analyzing fish body fluids iv) surface enhancement and optimization of spectral data and analysis. In a multidisciplinary approach that will encompass the scientific disciplines of molecular spectroscopy, biotechnology in biomedicine (especially veterinary medicine and food safety), general and applied microbiology, molecular biology, biochemistry, chemometrics and artificial intelligence. The application of ATR technology in this context opens up new possibilities in veterinary medicine, food safety, bioprospecting and biodiversity research. The methods developed within the project will have broad scientific and applied value, with the potential for implementation in various fields of science and industry.]]></summary_en></project><project>
<id>17580</id><title_hr><![CDATA[Zračenjem-inducirana sinteza visokoentropijskih slitina: nova katalitička rješenja za vodikovu ekonomiju]]></title_hr><title_en><![CDATA[Radiation-Induced Synthesis of High-Entropy Alloys: Novel Catalytic Solutions for Hydrogen Economy ]]></title_en><user_id>25099</user_id><user_firstLast_name>Ivan Marić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2025-02</proposal_call><code>UIP-2025-02-6925</code><acronim><![CDATA[RadHydroCats]]></acronim><duration>19.02.2026 - 18.02.2031</duration><status>U tijeku</status><financ_value>290.625,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, Interdisciplinarne prirodne znanosti, </scie_field_hr><scie_field_en>Chemistry, Interdisciplinary natural sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>21259, 25286, </team_members_id><team_members_names><![CDATA[Matea Raić, Matej Bubaš, ]]></team_members_names><keywords_hr><![CDATA[radiolitička sinteza, gama zračenje, visokoentropijske slitine, elektrokataliza, elektroliza vode, teorija funkcionala gustoće]]></keywords_hr><keywords_en><![CDATA[radiolytic synthesis, gamma-irradiation, high-entropy alloys, electrocatalysis, water splitting, density-functional theory]]></keywords_en><summary_hr><![CDATA[Rastuća globalna potražnja za energijom, u kombinaciji s geopolitičkom nestabilnošću u Europi, potaknula je intenzivan interes za smanjenjem ovisnosti o fosilnim gorivima te za razvojem novih obnovljivih izvora energije. Sustavi elektrokemijske konverzije i pohrane energije, uključujući gorive članke, elektrolizu vode, i baterije, izdvajaju se kao ključna rješenja. Među njima, vodik se ističe kao obećavajući energetski vektor za prijelaz na održivi energetski sustav i ugljično-neutralnu ekonomiju. Izvediva tehnologija za proizvodnju zelenog vodika je elektroliza vode (WE), koja se temelji na dvije elektrokemijske reakcije, naime reakciji evolucije vodika (HER) i reakciji evolucije kisika (OER). Napredni katalizatori za HER, odnosno OER temelje se na Pt i Ir. Budući da su i Pt i Ir skupi i rijetki, smanjenje njihove upotrebe uz održavanje performansi katalizatora je od najveće važnosti za ekonomsku izvedivost WE tehnologija. Kako bi se riješio ovaj problem, predloženo istraživanje fokusira se na razvoj visokoentropijskih slitina (HEA) kao naprednih elektrokatalizatora za WE koristeći novu radiolitičku metodu. Prednosti radiolitičke sinteze nad konvencionalnim fizičkim ili kemijskim metodama uključuju rad pri atmosferskom tlaku i sobnoj temperaturi te ekološka prihvatljivost. Glavna značajka HEA je stvaranje potpuno novih katalitičkih mjesta idealno prilagođenih za specifičnu reakciju, s potencijalno izvrsnom katalitičkom učinkovitosti. Naš cilj je racionalni dizajn i sinteza HEA korištenjem eksperimentalnog i teorijskog pristupa, posebno prilagođenih za HER i OER, s fokusom na minimiziranje upotrebe plemenitih metala (Pt, Ir i Ru) miješanjem s obilnijim prijelaznim metalima (Fe, Co, Ni, Cu, Cr, Mn, Mo, V, Zn). Nadalje, te HEA će biti deponirane na ugljiku visoke specifične površine i titanijevom oksinitridu, kako bi se maksimizirao broj aktivnih mjesta te dodatno poboljšala njihova aktivnost i stabilnost.]]></summary_hr><summary_en><![CDATA[The rising energy demand, coupled with the geopolitical instability in Europe, has intensified the need to reduce our reliance on fossil fuels and to develop new renewable energy technologies. Electrochemical energy conversion and storage systems, including fuel cells, water splitting, and batteries, are emerging as key solutions. Among these, hydrogen stands out as a promising energy vector for transitioning to a sustainable energy system and carbon-neutral economy. Feasible technology for green hydrogen production is water electrolysis (WE), which is based on two electrochemical reactions, namely hydrogen evolution reaction (HER) and oxygen evolution reaction (OER). State-of-the-art catalysts for HER and OER are based on Pt and Ir, respectively. Since both Pt and Ir are expensive and scarce, reducing their usage while keeping the performance in the catalysts is paramount for economic feasibility of the WE technologies. To tackle this problem, the proposed research focuses on developing high entropy alloys (HEAs) as advanced electrocatalysts for WE using a novel radiolytic method. Leverages of radiolytic synthesis over conventional physical or chemical methods involve operation at room temperature and atmospheric pressure and environmentally friendly synthesis. The main feature of HEAs is the creation of completely new catalytic sites ideal for a specific reaction, with potentially unprecedented catalytic performance.  We aim to rationally design and synthesize HEAs using a mixed experimental and theoretical approach specifically tailored for the HER and OER, with a focus on minimizing the use of precious metals (Pt, Ir and Ru) by mixing them with the more abundant transition metals (Fe, Co, Ni, Cu, Cr, Mn, Mo, V, Zn). Furthermore, these HEAs will be supported on high-surface-area carbon and titanium oxynitride supports, to maximize the number of exposed active sites and to additionally enhance their activity and stability.]]></summary_en></project><project>
<id>17585</id><title_hr><![CDATA[Učinak miješanih staklotvoraca: Otkrivanje potencijala strukturnih značajki za ugođeni električni prijenos i katalitičku aktivnost fosfatnih staklo-(keramika)]]></title_hr><title_en><![CDATA[Effect of Mixed Glass-Forming Oxides: Unlocking the Potential of Structural Features for Tailoring Electrical Transport and Catalytic Activity of Phosphate Glass-(Ceramics)]]></title_en><user_id>3421</user_id><user_firstLast_name>Luka Pavić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-7124</code><acronim><![CDATA[ECLECTIC GLASS]]></acronim><duration>30.12.2025 - 29.12.2028</duration><status>U tijeku</status><financ_value>199.870,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>3297, 865846, 865074, 57, 865588, 13669, 13670, 13648, 13189, </team_members_id><team_members_names><![CDATA[Ana Šantić, Marta Razum, Sara Marijan, Jana Pisk, Shiro Kubuki, Petr Mosner, Ladislav Koudelka, Gregory Tricot, Željko Skoko, ]]></team_members_names><keywords_hr><![CDATA[staklo, staklo-keramike, struktura, ionska vodljivost, polaronska vodljivost, elektrodni materijal, katalitička aktivnost]]></keywords_hr><keywords_en><![CDATA[glass, glass-ceramics, structure, ionic conductivity, polaronic conductivity, electrode material, catalytic activity]]></keywords_en><summary_hr><![CDATA[Fosfatna oksidna stakla s visokom električnom vodljivosti obećavajući su elektrolitni/elektrodni materijali za pohranu energije, ovisno o tipu električne vodljivosti (ionska, polaronska, miješana). Učinkovit način za povećanje ionske vodljivosti u ovim materijalima je zamjena jednog staklotvorca drugim, dok se alkalijski oksid održava konstantnim. Strukturna mreža sastavljena od miješanih jedinica olakšava ionsku pokretljivost kroz dobro poznati “učinak miješanih staklotvoraca” (MGFE). Zamjena klasičnog staklotvorca (P2O5) s uvjetnima, kao što su oksidi prijelaznih metala (TMO), od posebnog je interesa u alkalijskim fosfatnim staklima zbog različite uloge koju TMO mogu imati. Mogu utjecati na ionsku vodljivost na sličan način kao “klasični” MGFE i/ili mogu aktivno doprinijeti vodljivosti dodatnim polaronskim transportom koji proizlazi iz prijenosa elektrona između TM iona u različitim oksidacijskim stanjima, što dovodi do miješane ionsko-polaronske vodljivosti u staklu. Omjer između ionskog/polaronskog doprinosa ključan je za primjenu ovih materijala, dok ugađanje ovog odnosa predstavlja veliki znanstveni izazov. Predloženi projekt usmjeren je na razumijevanje mehanizama ionske i polaronske vodljivosti u alkalijskim vanadatno-fosfatnim staklima-(keramici) istraživanjem njihovog sastava, strukture i uvjeta priprave. Sastoji se od tri međusobno povezane komponente: (i) istraživanje alkalijskih vanadatno-fosfatnih stakala širokog raspona sastava (WP1, WP2), (ii) ispitivanje utjecaja ugradnje drugog TMO (WP3) na električni transport, s ciljem razvoja visoko vodljivog stakla-(keramike) s ugodljivom vodljivosti. Konačno, važan aspekt projekta uključuje proučavanje katalitičkih svojstava pripravljenih materijala za višenamjensku primjenu. Tehnike kao što su Raman/FTIR, MAS NMR, Mössbauer i EPR spektroskopija, PXRD, IS, DC mjerenja, mjerenja kapaciteta punjenja/pražnjenja, spregnuti TG-IR i GC osigurat će detaljnu karakterizaciju. ]]></summary_hr><summary_en><![CDATA[Highly conductive phosphate glasses are promising material for energy storage, serving as electrolytes or electrodes based on their electrical conductivity type (ionic, polaronic, or mixed). An efficient way to enhance ionic conductivity in these materials is by adding another glass-forming oxide while keeping alkali oxide constant. The structural network composed of mixed glass-formers units facilitates ionic mobility producing well-known “mixed glass former effect” (MGFE). Replacing the conventional glass former (P2O5) with the conditional ones, such as transition metal oxides (TMOs), in alkali phosphate glasses is highly promising, due to different roles TMOs can play. They can influence ionic conductivity in a similar manner to classical MGFE and/or can actively contribute to conduction via polaronic transport, originating from electron transfer between TM ions in different oxidation states. In the latter case, a mixed conductive glass is obtained. The ratio between ionic/polaronic contributions is pivotal for material applications, while its tunability poses a major scientific challenge. The proposed project aims to elucidate mechanisms governing ionic and polaronic conductivity in alkali vanadate-phosphate glasses-(ceramics) by investigating their composition, structure, and preparation conditions. It comprises three interconnected components: (i) exploring a wide range of alkali vanadate-phosphate glass compositions (WP1, WP2), (ii) investigating influence of incorporating additional TMO (WP3) on electrical transport, aiming to develop highly conductive glass-(ceramics) with tunable conductivity. Finally, an essential aspect of the project entails studying catalytic properties of prepared glasses-(ceramics) for multifunctional applications. Techniques such as Raman/FTIR, MAS NMR, Mössbauer and EPR spectroscopy, PXRD, IS, DC measurements, charge/discharge capacity measurements, and coupled TG-IR and gas chromatography will ensure comprehensive characterization]]></summary_en></project><project>
<id>17589</id><title_hr><![CDATA[Medicinska edukacija i planiranje uz pomoć produžene stvarnosti]]></title_hr><title_en><![CDATA[]]></title_en><user_id>21436</user_id><user_firstLast_name>Irena Galić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-7912</code><acronim><![CDATA[MEDITRAIN]]></acronim><duration>28.10.2025 - 27.10.2031</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera Osijek, Fakultet elektrotehnike, računarstva i informacijskih tehnologija Osijek]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Electrical Engineering, Computer Science and Information Technology Osijek]]></institution_en><team_members_id>872884</team_members_id><team_members_names><![CDATA[ Doktorand: Juraj Perić ]]></team_members_names><keywords_hr><![CDATA[Obrada medicinskih slika, strojno učenje, detekcija urasle posteljice, cerebrovaskularne procedure, produžena stvarnost  ]]></keywords_hr><keywords_en><![CDATA[Medical Image Processing, Machine Learning, Placenta Accreta Detection, Cerebrovascular procedures, Extended Reality (XR), ]]></keywords_en><summary_hr><![CDATA[Upotreba proširene stvarnosti (XR) u medicinskoj edukaciji i planiranju operativnih zahvata donosi značajne promjene u medicinskoj praksi. Napredni XR sustavi omogućuju stvaranje interaktivnih i realističnih simulacija, olakšavajući pripremu za složene operacije i pružajući dodatne informacije tijekom samih zahvata. Unatoč brzom razvoju ove tehnologije, postoji potreba za rješavanjem izazova vezanih uz dostupnost podataka, generiranje sintetičkih slučajeva i standardizaciju edukacije. Ovaj projekt je usmjeren na razvoj novih metoda i sustava koji će unaprijediti medicinsku edukaciju i planiranje operacija za specifična medicinska stanja i procedure. Cilj je razviti inovativne metode za simulaciju i analizu medicinskih slika uz pomoć algoritama strojnog učenja kojima će se (1) povećati iskustvo liječnika o urasloj posteljici i važnosti  njezina pregleda u trudnoći s ciljem smanjenja stope propuštenih slučajeva detekcije urasle posteljice pri pregledu trudnica ultrazvukom te (2) povećati lakoću izvedbe i kvalitetu cerebrovaskularnih zahvata izradom detaljne i realistične VR/XR simulacije specifičnih neurokirurških zahvata. Planirani sustavi se ističu po svojim inovativnim metodama u sintezi medicinskih slika. Za potrebe simulacije pregleda ultrazvuka razvit će se metode za sintezu realističnih ultrazvučnih slika iz slika magnetske rezonance koristeći spoj tradicionalnih i suvremenih metoda. Prilikom simulacije cerebrovaskularnih kirurških zahvata planira se razviti metoda koja će na temelju metoda generativne umjetne inteligencije kreirati nove, realistične i zahtjevne slučajeve ovisno o zadanim medicinskim parametrima. Rezultat projekta je  niz programskih biblioteka otvorenog koda koje će sadržavati sve razvijene metode tijekom projekta. Razvijene metode sintetičkog generiranja medicinskih slika omogućit će stvaranje raznovrsnih edukacijskih slučajeva, dok će VR/XR simulacije pružiti medicinskim stručnjacima priliku da unaprijede svoje vještine u sigurnom okruženju.]]></summary_hr><summary_en><![CDATA[The use of extended reality (XR) in medical education and surgical procedure planning brings significant changes to medical practice. Advanced XR systems enable the creation of interactive and realistic simulations, facilitating preparation for complex surgeries and providing additional information during the procedures themselves. Despite rapid technological development, challenges remain related to data availability, generation of synthetic cases, and standardization of education. This project focuses on developing new methods and systems to enhance medical education and surgical planning for specific conditions and procedures. The goal is to develop innovative methods for education, simulation, and analysis of medical images using machine learning algorithms that will (1) increase doctors&#39; experience regarding placenta accreta and the importance of its examination during pregnancy, thereby reducing the rate of missed cases of placenta accreta detection during ultrasound examination, and (2) increase the ease of execution and quality of cerebrovascular procedures by creating detailed and realistic VR/XR simulations of specific neurosurgical procedures. The planned systems stand out for their innovative methods in medical image synthesis. For ultrasound examination simulation, methods will be developed to synthesize realistic ultrasound images from magnetic resonance images using a combination of traditional and modern techniques. During the simulation of cerebrovascular surgical procedures, a generative artificial intelligence method will create new, realistic, and challenging cases based on given medical parameters. The project will result in a series of open-source software libraries containing all the methods developed. The methods for synthetic generation of medical images will enable the creation of diverse educational cases, while VR/XR simulations will provide medical professionals the opportunity to improve their skills in a safe environment.]]></summary_en></project><project>
<id>17590</id><title_hr><![CDATA[Strojno učenje za preciznu dijagnostiku i robotsku kirurgiju u onkologiji]]></title_hr><title_en><![CDATA[Machine Learning for Precision Diagnosis and Robotic Surgery in Oncology]]></title_en><user_id>24844</user_id><user_firstLast_name>Marija Habijan</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2025-02</proposal_call><code>UIP-2025-02-2755</code><acronim><![CDATA[ROBOMEDON]]></acronim><duration>01.04.2026 - 31.03.2031</duration><status>U tijeku</status><financ_value>297.848,85 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, Interdisciplinarne tehničke znanosti, </scie_field_hr><scie_field_en>Computer sciences, Interdisciplinary technological sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera Osijek, Fakultet elektrotehnike, računarstva i informacijskih tehnologija Osijek]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Electrical Engineering, Computer Science and Information Technology Osijek]]></institution_en><team_members_id>22468, 856226, 871005, 871035, 871008, 871036, 871023, 870567, 870728, </team_members_id><team_members_names><![CDATA[Hrvoje Leventić, Marin Benčević, Josip Samardžić, Petar Nakić, Danijel Marinčić, Branimir Bošnjak, Maja Čuletić Čondrić, Srdan Lazendic, Nives Grčić, ]]></team_members_names><keywords_hr><![CDATA[analiza medicinskih slika, medicinska dijagnostika, objašnjiva umjetna inteligencija, personalizirana medicina, robotska kirurgija, strojno učenje]]></keywords_hr><keywords_en><![CDATA[medical image analysis, medical diagnostics, explainable artificial intelligence, personalized medicine, robotic surgery, machine learning]]></keywords_en><summary_hr><![CDATA[Primjena strojnog učenja u medicinskoj dijagnostici i robotskoj kirurgiji donosi značajne promjene u onkološkoj praksi. Ovaj projekt obuhvaća cjelokupni dijagnostičko-terapijski proces onkološkog liječenja – od analize patoloških uzoraka do intraoperativne podrške tijekom kirurških zahvata. Napredni sustavi umjetne inteligencije (UI) omogućuju automatiziranu analizu medicinskih slika, preciznu navigaciju tijekom biopsija te poboljšanu intraoperativnu podršku, čime se povećava sigurnost pacijenata i učinkovitost kirurških zahvata. Unatoč napretku, i dalje postoje izazovi vezani uz dostupnost podataka, interpretabilnost AI modela te integraciju u kliničku praksu. Ovaj projekt usmjeren je na razvoj novih metoda strojnog učenja za dijagnostiku i robotsku kirurgiju s fokusom na onkološke bolesti. Cilj je razviti sustave (1) za automatsku analizu histopatoloških slika radi precizne identifikacije tumorskih biomarkera, (2) poboljšanje fuzijske biopsije prostate kombinacijom MRI i ultrazvučnih podataka, (3) razvoj AI podrške za intraoperativnu vizualizaciju neurovaskularnih struktura pomoću hiperspektralne analize, (4) razvoj sustava za automatsku analizu intraoperativnih videozapisa robotske kirurgije kako bi se unaprijedila preciznost kirurških postupaka te (5) poboljašanje integracije umjetne inteligencije u svakodnevnu kliničku praksu.  Planirani sustavi temelje se na naprednim modelima dubokog učenja, transformerske neuronske mreže, generativne metode i grafičke neuronske mreže. Posebna pažnja posvetit će se interpretabilnosti modela kroz pristupe objašnjive UI (XAI) te integraciju razvijenih rješenja u kliničke radne tokove putem standardiziranih API rješenja. Rezultat projekta bit će razvoj novih softverskih alata za analizu medicinskih slika i intraoperativnu podršku, čime se omogućuje preciznija i brža dijagnostika, optimizacija kirurških zahvata te poboljšanje kliničkih ishoda pacijenata kroz tehnološku inovaciju.]]></summary_hr><summary_en><![CDATA[The application of machine learning in medical diagnostics and robotic surgery brings significant changes to oncological practice. This project encompasses the entire diagnostic and therapeutic process of oncological treatment – from the analysis of pathological samples to intraoperative support during surgical procedures. Advanced artificial intelligence (AI) systems enable automated analysis of medical images, precise navigation during biopsies, and improved intraoperative support, enhancing patient safety and the efficiency of surgical procedures. Despite these advancements, challenges remain regarding data availability, AI model interpretability, and clinical integration. This project focuses on developing new machine learning methods for diagnostics and robotic surgery, with an emphasis on oncological diseases. The goal is to develop systems for automated analysis of histopathological images to precisely identify tumor biomarkers, enhancing fusion biopsy of the prostate by combining MRI and ultrasound data, developing AI support for intraoperative visualization of neurovascular structures using hyperspectral analysis, creating a system for automated analysis of intraoperative videos from robotic surgery to improve surgical precision, and enhancing the integration of artificial intelligence into everyday clinical practice. The planned systems will be based on advanced machine and deep learning methods, including transformer neural networks, generative methods, and graph neural networks. Special attention will be given to model interpretability through explainable AI (XAI) approaches and the integration of developed solutions into clinical workflows via standardized API solutions. The project will result in the development of new software tools for medical image analysis and intraoperative support, enabling more accurate and faster diagnostics, optimizing surgical procedures, and improving patient clinical outcomes through technological innovation.]]></summary_en></project><project>
<id>17591</id><title_hr><![CDATA[Fotometrijsko određivanje udaljenosti i  strukture galaksije pomoću podataka „Legacy Survey of Space and Time” pregleda neba Vera C. Rubin  opservatorija]]></title_hr><title_en><![CDATA[Photometric Distance Estimation and Structure of the Milky Way Galaxy with Vera C. Rubin’s Legacy Survey of Space and Time]]></title_en><user_id>24834</user_id><user_firstLast_name>Lovro Palaversa</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-1942</code><acronim><![CDATA[Photo-D]]></acronim><duration>05.12.2025 - 04.12.2028</duration><status>U tijeku</status><financ_value>199.941,35 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>19010, 25689, 871098, </team_members_id><team_members_names><![CDATA[Vibor Jelić, Zeljko  Ivezic, Mario Juric, ]]></team_members_names><keywords_hr><![CDATA[zvijezde, galaksija, udaljenosti, Mliječni put,  evolucija zvijezda, međuzvjezdana tvar]]></keywords_hr><keywords_en><![CDATA[stars, Galaxy, distances, Milky Way,  stellar evolution, interstellar matter, ISM]]></keywords_en><summary_hr><![CDATA[Analogno fotometrijskim procjenama udaljenosti galaksija i kvazara (&#39;&#39;photo-z&#39;&#39;), predlažemo fotometrijsku metodu određivanja udaljenosti zvijezda, photo-D, za procjenu udaljenosti desetaka milijardi zvijezda zvijezda koje će biti opažene pregledom neba &#39;&#39;Legacy Survey of Space and Time&#39;&#39; Vera C. Rubin opservatorija. Predložena metoda koristi astrofizičke boje i temelji se na potpuno bayesovskom pristupu određivanja sjaja, kemijskog sastava, površinske gravitacije i zatamnjenja zbog međuzvjezdane tvari na doglednici, kako bi se procijenila udaljenost do zvijezda. Ovi dodatni podaci omogućit će istraživanja Mliječnog puta od testiranja modela njegova nastanka i razvoja do potrage za zvjezdanim tokovima koji su izvrsni pokazatelji raspodjele tamne tvari. Znanstveni utjecaj takvog javno dostupnog kataloga kojeg namjeravamo objaviti uz svaku novu objavu LSST podataka biti će značajan: ekstrapolirajući iz dosadašnjih istraživanja kao što su SDSS, Pan-STARRS, DES i Gaia, predloženi katalog bi omogućio bi stotine, ako ne i tisuće novih radova i rezultirao neviđenim mapama Mliječne staze koje se protežu sve do pretpostavljenog galaktičkog ruba haloa na nekoliko stotina kiloparseka.]]></summary_hr><summary_en><![CDATA[In analogy with photometric distance estimates for galaxies and quasars (&#39;&#39;photo-z&#39;&#39;), we propose photometric stellar distance estimation method, photo-D, -- that produces color-based estimates of distances for tens of billions of stars that will be observed by the Vera C. Rubin Observatory&#39;s Legacy Survey of Space and Time. This fully Bayesian procedure also produces estimates of stellar parameters such as metallicity and surface gravity, and interstellar dust extinction along the line of sight to each star. These additional LSST data products will enable studies of the Milky Way ranging from tests of models for its formation and evolution to search for stellar streams which are excellent probes of dark matter distribution. The scientific and community impact of such a publicly available catalog to accompany each LSST Data Release would be enormous: extrapolating from extant surveys such as SDSS, Pan-STARRS, DES and Gaia, it would enable many hundreds, if not thousands of papers and result in unprecedented maps of the Milky Way extending all the way to the presumed halo edge at several hundred kiloparsecs.]]></summary_en></project><project>
<id>17593</id><title_hr><![CDATA[Difuzno zagađenje riječnog ekosustava: od nano onečišćenja do bioloških i ekoloških učinaka]]></title_hr><title_en><![CDATA[Diffuse riverine ecosystem pollution: from nano contamination to biological and ecological effects]]></title_en><user_id>11261</user_id><user_firstLast_name>Zrinka Dragun</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-2068</code><acronim><![CDATA[BeDIFFERENCE]]></acronim><duration>05.12.2025 - 04.12.2028</duration><status>U tijeku</status><financ_value>199.985,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Interdisciplinarne prirodne znanosti, Geologija, Kemija, Biologija, </scie_field_hr><scie_field_en>Interdisciplinary natural sciences, Geology, Chemistry, Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>5805, 11251, 21287, 26083, 865007, 20750, 865480, 12386, 2762, 867731, 870446, 26150, 867749, 867742, 870036, </team_members_id><team_members_names><![CDATA[Damir Valić, Dušica Ivanković, Tatjana Mijošek Pavin, Tomislav Kralj, Zoran Kiralj, Branka  Bilić, Sonja Tolić, Jasna Lajtner, Josip Barišić, Katerina Rebok, Milica Ristovska, Maria Montes-Bayon, Mario Corte Rodriguez, Maikel Rosabal Rodriguez, Nataša Tepić, ]]></team_members_names><keywords_hr><![CDATA[bioraznolikost, ribe, mekušci, bakterije, bioakumulacija, nanočestice, biomarkeri, metaloproteini, metali, pesticidi]]></keywords_hr><keywords_en><![CDATA[biodiversity, fishes, molluscs, bacteria, bioaccumulation, nanoparticles, biomarkers, metalloproteins, metals, pesticides]]></keywords_en><summary_hr><![CDATA[Zagađenje slatkih voda iz difuznih izvora vodeći je uzrok opadanja njihove kakvoće, s negativnim učinkom na zdravlje ekosustava i bioraznolikost, a na nužnost prepoznavanja ključnih zagađivala i njihovih izvora, kao i osjetljivosti okoliša u koji se unose, upućuje i europska regulativa. Naš je cilj istražiti reprezentativan slatkovodni ekosustav izložen prvenstveno utjecaju difuznih izvora zagađenja (rijeka Mura u Hrvatskoj), te utvrditi stupanj onečišćenja vode/sedimenta metalima/organskim zagađivalima i izdvojiti najkritičnija zagađivala. Nadalje, cilj nam je definirati dugotrajnu ovisnost onečišćenja riječne vode metalima/nutrijentima o hidrološkom režimu, putem mjesečnih mjerenja tijekom dviju godina (ukupno 24 uzorkovanja). Učinke difuznog zagađenja pratit ćemo na slatkovodnim organizmima različite biološke složenosti i različitih stanišnih i prehrambenih preferencija (odnosno, na bakterijama, mekušcima (puževima/školjkašima), te bentičkim i pelagičkim ribama). Analizirat ćemo bioakumulaciju metala u odabranim ciljnim organima navedenih organizama (u jetri, gonadama i mišiću riba; u probavnoj žlijezdi/cijelomu mekom tkivu mekušaca), kao i njihovu raspodjelu/specijaciju u tim tkivima, određivanjem nanočestica metala i substanične raspodjele metala te izučavanjem biomolekula koje vežu metale. Biološke i ekološke učinke difuznog zagađenja na odabrane akvatičke organizme utvrdit ćemo izučavanjem molekularnih i biokemijskih biomarkera te bioraznolikosti riba (primjenom morfološke determinacije i eDNA), kao biomarkera visokog ekološkog značaja. Uz znanstvenu vrijednost, vezano uz proširenje znanja o povezanosti između izloženosti organizama zagađivalima iz difuznih izvora, njihove bioakumulacije i raspodjele te bioloških/ekoloških učinaka, ovaj će projekt imati i ekološki i obrazovni značaj, pružanjem opsežnih informacija o kakvoći slatkovodnog ekosustava zaštićenog na nacionalnoj i međunarodnoj razini, te prenošenjem znanja i usavršavanjem mladih znanstvenika.]]></summary_hr><summary_en><![CDATA[The pollution from diffuse sources is the leading cause of freshwater quality impairment, with negative impact on ecosystem health and biodiversity. European regulations recommend to identify pollutants and their sources, and the sensitivity of the receiving environment. Our aim is to study the representative freshwater ecosystem impacted predominantly by diffuse pollution sources (the Mura River in Croatia), to establish the degree of water/sediment contamination with metals/organic compounds, and single out the most critical contaminants. Our further aim is to define long-term dependence of river water contamination with metals/nutrients on hydrological regime, through monthly measurements during two years (24 in total). Impacts of diffuse pollution will be monitored in freshwater organisms of different biological complexity, habitats and feeding habits (i.e., bacteria, molluscs (gastropods, bivalves), benthic/pelagic fishes). We will analyse metal bioaccumulation in selected target organs of these organisms (fish liver, gonads, muscle; digestive gland/whole soft tissue of molluscs), as well as their distribution/speciation, by assessing the nanoparticulate metals and subcellular metal partitioning, and studying metal-binding biomolecules. Biological/ecological effects of diffuse pollution in selected aquatic organisms will be established by studying molecular/biochemical biomarkers, and fish biodiversity (by morphological determination and eDNA), as a biomarker of high ecological relevance. In addition to scientific value, referring to extended knowledge on links among exposure of organisms to pollutants from diffuse sources, their bioaccumulation/distribution and biological/ecological effects, this project will also have ecological and educational importance. It will provide comprehensive information on the quality of the freshwater ecosystem protected at the national/international level, and contribute to transfer of knowledge and training of young scientists. ]]></summary_en></project><project>
<id>17594</id><title_hr><![CDATA[Translacijska platforma za poboljšano predviđanje patogenosti varijanti OPTN gena u amiotrofičnoj lateralnoj sklerozi i srodnim neurodegenerativnim bolestima]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4630</user_id><user_firstLast_name>Ivana Munitic</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-5918</code><acronim><![CDATA[TranslateOPTNvar2NDD]]></acronim><duration>07.11.2025 - 06.11.2031</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Interdisciplinarno područje znanosti</scie_area_hr><scie_area_en>Interdisciplinary scientific area</scie_area_en><scie_field_hr>Biotehnologija u biomedicini, </scie_field_hr><scie_field_en>Biotechnology in Biomedicine, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Fakultet biotehnologije i razvoja lijekova]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Biotechnology and Drug Development]]></institution_en><team_members_id>872888</team_members_id><team_members_names><![CDATA[ Doktorand: Ema Jalšić ]]></team_members_names><keywords_hr><![CDATA[optineurin, neurodegeneracija, neuroinflamacija, imunodeficijencija, proteinopatija]]></keywords_hr><keywords_en><![CDATA[optineurin, neurodegeneration, neuroinflammation, immunodeficiency, proteinopathy]]></keywords_en><summary_hr><![CDATA[Terapije amiotrofične lateralne skleroze (ALS), frontotemporalne demencije (FTD) i srodnih neurodegenerativnih bolesti (NDD) važan su medicinski izazov. Genetski oblici ALS-a i FTD-a uzrokovani su mutacijama u više od 50 gena. ALS/FTD gen OPTN povezuje ključne značajke NDD-a, neuroupalu i proteinopatiju, predstavljajući potencijalni terapeutski cilj. Međutim, samo za nekolicinu OPTN mutacija potvrđeno je da uzrokuju NDD, a trenutni programi za predviđanja patogenosti za varijante nepoznatog značaja (VUS) su neprecizni. Štoviše, trenutna istraživanja na mišjim i staničnim OPTN modelima, slično modelima partnerske TBK1 kinaze, nisu adresirala sve funkcije optineurina i TBK1, posebno one  vezane uz imunosni sustav. Ovdje predlažemo poboljšati translacijski učinak istraživanja OPTN gena povezivanjem: 1) analiza proteinskih interakcija i procesa na koje utječu varijante OPTN gena, 2) računalnih strukturnih analiza za poboljšanje predviđanja patogenosti VUS-a i pronalazak terapijskih ciljeva, 3) validacija u organotipskim rezovima mozga, stanicama diferenciranim iz monocita zdravih ispitanika (+/-utišavanje OPTN-a) i OPTN pacijenata. U tu ćemo svrhu mapirati interaktom divljeg i mutiranog OPTN-a (povezanog s ALS/FTD i glaukomom) u HMC3 ljudskoj mikrogliji i SH-SY5Y neuronskim linijama. Ex vivo relevantnost mapiranih putova testirat će se u funkcionalnim testovima u organotipskim kortikalnim rezovima mozga napravljenim iz palete naših originalnih OPTN mišjih modela, a potom i u ljudskim uzorcima. Također ćemo generirati prediktivni program za VUS OPTN-a baziran na analizi proteinske strukture i proteinskih interakcija iz postojećih i novogeneriranih proteomskih i funkcionalnih analiza. Zaključno, predlažemo uspostaviti dvosmjernu platformu za proširenje razumijevanja OPTN varijanti i terapijskih ciljeva u NDD.]]></summary_hr><summary_en><![CDATA[Therapies in amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD) and related neurodegenerative diseases (NDD) remain a major unmet medical need. Genetic forms of ALS and FTD are caused by mutations in 50+ genes. ALS/FTD-linked gene OPTN links key NDD features, neuroinflammation and proteinopathy, presenting a potential therapeutic target. However, only a handful of OPTN mutations clearly segregate with individual NDDs, and current pathogenicity prediction programs for variants of unknown significance (VUS) are imprecise and thus incapable to guide clinical decisions. Moreover, the current OPTN mouse and cellular models, similar to ALS-models based on its partner TBK1 kinase, yet have to address the full spectrum of functions affected by the patient mutations, especially those relating to the immune system. Here we propose to improve translational impact of research on OPTN by connecting: 1) analysis of protein:protein interactions and pathobiological processes affected by OPTN variants, 2) computational structural analysis to improve VUS pathogenicity prediction, prioritize research and map therapeutic targets, 3) validation in organotypic brain slices, monocyte-derived cells from healthy subjects (+/-OPTN silencing) and OPTN patients. To this end, we will map the interactome of wild type and mutated OPTN (ALS/FTD- and glaucoma-linked) in HMC3 human microglia and SH-SY5Y neuronal lines by proximity labelling proteomics. Ex vivo relevance of mapped pathways will be tested in functional assays in organotypic cortical brain slices from a palette of our original OPTN mouse models and subsequently in human samples.  We will also generate a predictive program for OPTN VUS by analysing protein structure and protein interactions from existing and newly generated proteomic and functional analyses. Overall, we propose to assemble a two-way translational platform for expanding the mechanistic understanding of OPTN variants and NDD therapeutic targets. ]]></summary_en></project><project>
<id>17595</id><title_hr><![CDATA[Istraživanje dubrovačke rasjedne zone višeskalnim pristupom]]></title_hr><title_en><![CDATA[Multiscale imaging of the Dubrovnik fault system]]></title_en><user_id>199</user_id><user_firstLast_name>Josip Stipčević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-2015</code><acronim><![CDATA[MDuFAULT]]></acronim><duration>10.12.2025 - 09.12.2028</duration><status>U tijeku</status><financ_value>194.350,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Geofizika, Geologija, </scie_field_hr><scie_field_en>Geophysics, Geology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>870640, 869797, 26762, 37, 39, 12922, 208, 870707, 864925, 870704, 11151, 870702, 29661, 7702, 870653, </team_members_id><team_members_names><![CDATA[Irene Molinari, Ivana Zonjić, Marin Sečanj, Marijan Herak, Davorka Herak, Krešimir Kuk, Iva Dasović, Stephane Rondenay, Snježana Cvijić Amulić, Milan Janjić, Branko Kordić, Stojan Babić, Tena Belinić Topić, Bruno Tomljenović, Enrico Serpelloni, ]]></team_members_names><keywords_hr><![CDATA[Dubrovnik, potres, rasjed, modeliranje, višeskalno, svjetlovod, GNSS]]></keywords_hr><keywords_en><![CDATA[Dubrovnik, earthquake, fault, modelling, multiscale, fiber optic, GNSS]]></keywords_en><summary_hr><![CDATA[Predloženo istraživanje bavi se proučavanjem strukture i dinamike glavne deformacijske fronte Južnih Dinarida, odgovorne za neke od najjačih potresa u Europi u posljednjih nekoliko stoljeća. Ovo područje je postalo žarište istraživanja o interakciji dvije tektonske ploče, Jadranske i Euroazijske. Unatoč brojnim novim spoznajama, i dalje nedostaju precizni podaci o strukturi gornje kore i obrascima pojave jakih potresa. Glavni razlog tome je nepovoljna prostorna raspodjela i nedovoljna gustoća seizmičkih postaja. U projektu predlažemo višeskalno istraživanje središnjeg dijela ovog aktivnog rasjednog sustava koristeći napredne seizmološke metode u kombinaciji s geodetskim i geološkim mjerenjima.U sklopu studije, postavit će se gusta mreža novih seizmičkih stanica u kombinaciji s  već postojećom lokalnom mrežom, te će se koristiti distribuirano akustičko mjerenje (DAS) da bi se postigla visoka rezolucija pri istraživanja podzemlja i detektirali slabi potresi. Paralelno će se provesti nekoliko kampanja GNSS mjerenja, omogućujući precizno praćenje deformacije tla i promjene naprezanja, dok će geološka istraživanja pružiti ključne informacije o strukturi rasjedne zone i procesima akumulacije naprezanja.Detaljna analiza seizmoloških podataka provest će se korištenjem najsuvremenijih tehnika strojnog učenja, čime će se omogućiti istraživanje prostorne i vremenske promjenjivosti seizmičnosti i strukture podzemlja. Za istraživanje šireg tektonskog okvira upotrijebit će se pasivne seizmičke metode, pružajući dublji uvid u dinamiku rasjednog sustava.Integracijom najnovijih tehnoloških dostignuća na temelju multidisciplinarnog pristupa i naprednih tehnika analize podataka, planiramo napraviti detaljnu sliku podzemnih struktura, čime ćemo poboljšati razumijevanje aktivnih rasjeda i regionalne tektonike. Ovaj projekt postavit će temelje za precizniju procjenu seizmičkog hazarda, što će izravno pridonijeti smanjenju potresne ugroženosti jugoistočne obale Jadrana.]]></summary_hr><summary_en><![CDATA[This research focuses on examining structure and dynamics of the South Dinarides deformation front responsible for some of the largest earthquakes in Europe in the last several centuries. Recently, the region has become the pivot point in the vigorous investigation of the interaction between Adriatic and Eurasian tectonic plates. Although these studies uncovered numerous new findings detailed knowledge about the upper crustal structure and seismicity pattern are still missing, mostly due to unfavorable spatial layout and insufficient density of seismic stations in the area. This project aims to fill this gap by conducting a novel multiscale imaging study of the central part of this fault system using advanced seismological methods alongside well established geodetic and geological approaches.The study will integrate new, densely deployed, seismic stations with existing local seismic network along with Distributed Acoustic Sensing (DAS) measurements for high-resolution seismic imaging. This data will be supplemented with GNSS campaign measurements to track ground deformation and strain changes, while geological investigations will provide insights into fault structure and stress accumulation. The detailed analysis of the entire seismological dataset will be performed using the most up-to-date machine learning techniques in order to investigate the spatial and temporal changes in structure and seismicity. The large scale tectonic outline will be imaged using variety of passive seismic methods.By integrating new technological advances with multi-disciplinary approach and state-of-the-art methodologies we plan to image subsurface structure at unprecedented resolution at several scales improving our understanding of fault behavior and regional tectonics. This project, by establishing a data-driven and adaptable approach integrating various measurements will pave the way for a more accurate assessment of seismic hazard in the southeastern Adriatic region.]]></summary_en></project><project>
<id>17599</id><title_hr><![CDATA[Napredni meki roboti: razvoj, modeliranje i regulacija na temelju eksperimentalnih podataka]]></title_hr><title_en><![CDATA[Advanced soft robots: data-driven development, modeling and control]]></title_en><user_id>11318</user_id><user_firstLast_name>Ervin Kamenar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2025-02</proposal_call><code>UIP-2025-02-1541</code><acronim><![CDATA[ASoRo]]></acronim><duration>19.02.2026 - 18.02.2031</duration><status>U tijeku</status><financ_value>257.200,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, Interdisciplinarne tehničke znanosti, </scie_field_hr><scie_field_en>Mechnical engineering, Interdisciplinary technological sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Tehnički fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Engineering]]></institution_en><team_members_id>868316, 870064, 29574, 26070, </team_members_id><team_members_names><![CDATA[Tomislav Bazina, Adelmo Šegota, Jelena Srnec Novak, David Liović, ]]></team_members_names><keywords_hr><![CDATA[meka robotika, rehabilitacijska robotika, biomehatronička konstrukcija, modeliranje i regulacija, Kopman operator, elektromiografija (EMG), predikcija]]></keywords_hr><keywords_en><![CDATA[soft robotics, rehabilitation robotics, biomechatronic design, modeling and control, Koopman operator, electromyography (EMG), grip force forecasting]]></keywords_en><summary_hr><![CDATA[U posljednjih 15-ak godina, bilježi se eksponencijalni porast istraživanja mekih robota inspiriranih prirodom. U usporedbi s tradicionalnim robotima, oni znatno poboljšavaju sigurnost interakcije između čovjeka i stroja, zbog čega postaju sve atraktivniji u raznim medicinskim područjima, uključujući rehabilitacijsku robotiku. Međutim, njihov razvoj, modeliranje i regulacija otežani su njihovom nelinearnošću te formalno beskonačnim brojem stupnjeva slobode gibanja, što ograničava njihovu primjenu izvan laboratorija. Kao nastavak na prethodno istraživanje voditelja projekta „Control of soft robots with inertial dynamics“ objavljeno u časopisu Science Robotics (2-godišnji IF: 26.1), predloženi projekt ima za cilj rješavanje ovih izazova koristeći biomehatroničke pristup te osnivanje nove interdisciplinarne istraživačke grupe i „Laboratorija za bioinspiriranu robotiku“. Primjenom teorije Koopman operatora, provodit će se modeliranje i određivanje regulatora koji se mogu primijeniti na uređaje za rehabilitaciju temeljene na mekoj robotici. Podaci će se dobivati pomoću sustava za beskontaktno praćenje pomaka, a istraživanje će uključivati i razvoj metodologije za modeliranje i predviđanje snage stiska šake mjerenjem aktivnosti mišića pomoću elektromiografskih osjetnika. Ovaj pristup omogućit će adaptivno upravljanje uređajem i prilagođavanje izvršne sile uređaja subjektu, radi poticanja oporavka tijekom procesa rehabilitacije. Nadalje, kroz interdisciplinarni pristup i suradnju između inženjera i medicinskih stručnjaka, istražiti će se preduvjeti potrebni za razvoj mekih robota primjenjivih u rehabilitacijskoj robotici, uključujući analizu kinematike, odabir materijala i konstrukciju. Provest će se analitičko i numeričko modeliranje s ciljem optimizacije struktura i povećanja njihove trajnosti i pouzdanosti. Konačno, razvit će se prototip dokaza koncepta inovativne meke robotske rukavice za rehabilitaciju pacijenata sa smanjenom pokretljivošću ruku.]]></summary_hr><summary_en><![CDATA[Over the past 15 years, the study of nature-inspired soft robots has grown exponentially. Compared to rigid robots, they have tremendously improved human-machine interaction safety. As a result, they have become increasingly attractive in various medical fields, including robotic rehabilitation. However, inherent nonlinearity and formally infinite degrees of freedom hinder their development, modeling, and control, limiting their use outside the laboratory. Building on the Principal Investigator’s previous study “Control of Soft Robots with Inertial Dynamics” published in Science Robotics (2-year IF: 26.1), the proposed project aims to address these challenges within a biomechatronic design framework by establishing a new interdisciplinary research group and the “Laboratory for Bioinspired Robotics.” Leveraging the Koopman operator framework, data-driven modeling and development of controllers applicable to soft rehabilitation robots will be carried out. Data will be acquired using a motion capture system, and a method for modeling and forecasting grip strength through electromyographic sensors will be developed. This approach will enable real-time adaptivity of the device, allowing for adjustment of output force to optimize patient recovery during rehabilitation. In addition, by leveraging an interdisciplinary approach and fostering collaboration between engineers and medical experts, the project will examine the critical prerequisites for developing soft robots suitable for rehabilitation purposes. This includes conducting kinematic analyses of motion, selecting appropriate materials, and refining design parameters. Numerical and analytical models will be developed to optimize the designs and to achieve better durability and reliability, with experimental analyses validating these designs. The project will culminate in the development of a proof-of-concept prototype of an innovative soft robotic glove designed to rehabilitate patients with reduced hand mobility.]]></summary_en></project><project>
<id>17601</id><title_hr><![CDATA[Razumijevanje kritičke procjene u zdravstvenoj praksi i istraživanju]]></title_hr><title_en><![CDATA[Understanding Critical Assessment in Health Practice and Research]]></title_en><user_id>776</user_id><user_firstLast_name>Ana Marušić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-6099</code><acronim><![CDATA[HealthAssess]]></acronim><duration>05.12.2025 - 04.12.2028</duration><status>U tijeku</status><financ_value>200.000,00 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Javno zdravstvo i zdravstvena zaštita, Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Public health and health services, Clinical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Split School of Medicine]]></institution_en><team_members_id>25225, 4510, 5404, 22661, 20309, 25888, 867636, 25870, 868047, 868009, 26028, 868015, 868007, 26348, 868012, 868008, 26405, 868026, 865474, 869794, 868013, 865114, 861719, </team_members_id><team_members_names><![CDATA[Marin Viđak, Livia Puljak, Tina Poklepović Peričić, Marija Roguljić, Ljubo Znaor, Francisco Grimaldo, Emilia Lopez-Inesta, David Pina, Danira Matijaca, Kaja Mandić, Ružica Tokalić, Romana Jadrijević, Jelena Hrga, Mariano Kaliterna, Jure Krstulović, Zrinka Hrgović, Danijel Gudelj, Marin Šunjić, Luka Ursić, Nina Vitlov, Miro Vuković, Nensi Bralić, Antonija Mijatović, ]]></team_members_names><keywords_hr><![CDATA[medicina temeljena na dokazima, kritička procjena, znanstveno istraživanje, transparencija, integritet, ponovljivost, etika]]></keywords_hr><keywords_en><![CDATA[evidence-based medicine, critical assessment, scientific research, transparency, integrity, reproducibility, ethics]]></keywords_en><summary_hr><![CDATA[Predloženi projekt nastavlja istraživanja profesionalizma u zdravstvu iz prethodnog HRZZ projekta. U ovom se projektu usredotočujemo na dublje razumijevanje o kritičkoj procjeni u zdravstvenoj skrbi i znanosti. Dva istraživačka radna paketa bit će komplementarna i posvećena proučavanju kritičke procjene u zdravstvenoj praksi i u znanstvenom istraživanju. Prva istraživačka tema primarno je usmjerena je na to kako različiti dionici u zdravstvenoj skrbi (pacijenti, liječnici/istraživači i studenti kao budući liječnici) razumiju rezultate znanstvenih istraživanja i primjenjuju je u praksi, od jednostavnih informacija do složenih sinteza zdravstvenih dokaza. Druga istraživačka tema usmjerena je kritičku procjenu u širem kontekstu znanstvene evaluacije, od recenzijskog postupka u časopisima do evaluacije znanstvenih projekata. Istražit ćemo čimbenike koji utječu na različite aspekte kritičke procjene, od utjecaja organizacijske okoline, do čimbenika čestitosti, etike i znanstvene ponovljivosti. Pristup svakom specifičnom cilju istraživanja bit će utemeljen na trenutnom znanju i identifikaciji relevantnih istraživačkih pitanja; na uporabi adekvatnih istraživačkih ustroja, kvalitativnih i kvantitativnih/eksperimentalnih i inovativnih metodologija, uključujući strojno učenje i računalnu jezičnu analizu; na sintezi rezultata u eksplanatorne teorije i modele; te na razvoju oruđa i diseminaciju rezultata važnih za javnu politiku znanosti i pristup zdravstvenoj skrbi. Bolje razumijevanje kritičke procjene u zdravstvenoj praksi i znanosti općenito donijet će nove spoznaje i oruđa za poboljšanje zdravstvene skrbi i donijeti važne ekonomske i javnozdravstvene koristi. Dobiveni rezultati pomoći će i u boljem razumijevanju znanstvenog procesa, posebice dobrih istraživačkih praksi.]]></summary_hr><summary_en><![CDATA[The proposed project aims to continue the research on professionalism in health from the previous HRZZ project. In this proposal, we focus on deeper understanding of the process of critical assessment as an important aspect of health care and scientific research in general. Two project research themes will be complementary and dedicated to the study of critical assessment and scientific research, respectively. The first research theme will primarily focus on how different stakeholders (patients, doctors/researchers, and students as future researchers) understand the results of health research and use it in practice, from simple health information to complex evidence synthesis. The second research theme will focus on critical assessment in the wider context of scientific evaluation, from the journal peer-review process to the evaluation of research proposals. We will explore factors that influence different aspects of critical assessment, from the importance of organisational environment to the integrity, ethics and reproducibility factors. Each specific objective of the proposed research will be based on current evidence and identified knowledge gaps; it will use appropriate research design and innovative methodological tools, including machine learning anddeep language analysis; it will synthesise research results into explanatory theories and models; and will develop tools and disseminate results and experience relevant for policy and public use. Better understanding of critical assessment in health practice and scientific research in general will provide evidence and new tools to inform improving health care and bring important economic and public health benefits. Anticipated project results will also help in better understanding of the research process, especially good research practices. ]]></summary_en></project><project>
<id>17605</id><title_hr><![CDATA[Ljudski kortiko-motorni asembloidi otkrivaju ulogu DYRK1A gena u Downovom sindromu]]></title_hr><title_en><![CDATA[Human Cortico-Motor Assembloids reveal the role of the DYRK1A gene in Down syndrome]]></title_en><user_id>12687</user_id><user_firstLast_name>Ivan Alić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2025-02</proposal_call><code>UIP-2025-02-5828</code><acronim><![CDATA[AssembloiDS]]></acronim><duration>19.02.2026 - 18.02.2031</duration><status>U tijeku</status><financ_value>300.000,00 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, Veterinarska medicina, </scie_field_hr><scie_field_en>Basic Medical Sciences, Veterinary medicine, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Veterinarski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Veterinary Medicine]]></institution_en><team_members_id>24835, 865739, 855903, 867726, </team_members_id><team_members_names><![CDATA[Matija Horaček, Gillian Gough, Petra Šoštarić, Sandra Kunštek, ]]></team_members_names><keywords_hr><![CDATA[Downov Sindrom, iPSCs, Neuroni, Asembloidi,  neuro-mišićni spoj]]></keywords_hr><keywords_en><![CDATA[Down Syndrome, iPSCs, Neurons, Assembloids, neuro-muscular junction]]></keywords_en><summary_hr><![CDATA[Down sindrom (DS) najčešći je kongenitalni uzrok intelektualnih poteškoća i najčešći genetski uzrok ranog početka Alzheimerove bolesti (AD). Ovaj projekt temelji se na snažnim preliminarnim opažanjima stanično-intrinzičnih promjena uzrokovanih trisomijom kromosoma 21 (T21) u neuronima dobivenim iz ljudskih induciranih pluripotentnih matičnih stanica (iPSCs) te u fetalnim tkivima s T21. Te promjene utječu na razvoj neurita, sinaptogenezu i plastičnost, pridonoseći elektrofiziološkim abnormalnostima. Naša hipoteza je da su dvije kopije gena DYRK1A nužne i dovoljne za normalnu morfologiju neurona te za formiranje neuromuskularnih spojeva (NMJs). Koristeći iPSCs modele izogenične i parcijalne T21, kao i CRISPR-korigirane klonove, analizirat ćemo ulogu gena DYRK1A u formiranju i funkciji NMJ-a u 2D (neuroni-Schwannove stanice-miotubuli) i 3D strukturama (kortiko-motorni asembloidi). Rezultati će se analizirati histološkim i molekularnim metodama, a u četvrtoj i petoj godini projekta provest će se elektrofiziološke analize. Dobiveni in vitro rezultati usporedit će se s velikom zbirkom tkiva iz ljudske banke tkiva. Na kraju, rezultati će se dodatno usporediti s Dp1Tyb miševima, koji nose tri kopije svih 148 gena s ljudskog kromosoma 21. Ovaj projekt će omogućiti bolje razumijevanje uloge gena DYRK1A u DS-u te njegovog utjecaja na razvoj i funkciju neurona.]]></summary_hr><summary_en><![CDATA[Down syndrome (DS) is the most common congenital cause of intellectual disability and the most common genetic cause of early-onset Alzheimer’s disease (AD). This project is based on strong preliminary observations of cell-intrinsic changes caused by trisomy of chromosome 21 (T21) in human induced pluripotent stem cell (iPSCs)-derived neurons and T21 foetal tissues. These changes affect neurite development, synaptogenesis, and plasticity, contributing to electrophysiological abnormalities. Our hypothesis is that two copies of the DYRK1A gene are both necessary and sufficient for normal neuronal morphology and the formation of neuromuscular junctions (NMJs). Using iPSCs models with isogenic and partial T21, as well as CRISPR-edited clones, we will analyse the role of DYRK1A in the formation and function of NMJs in both 2D (neurons-Schwann cells-myotubes) and 3D (cortico-motor assembloids) models. Our data will be validated using histological and molecular methods. In the fourth and fifth years of the project, electrophysiological analyses will be performed. The in vitro data will be compared with a large collection of tissues from a human brain bank. Finally, the results will be further validated using Dp1Tyb mice, which carry three copies of all 148 genes found on human chromosome 21. The findings from this project will clarify the role of DYRK1A in DS and its impact on neuronal development and function.]]></summary_en></project><project>
<id>17610</id><title_hr><![CDATA[Mehanokemijske strategije ka novim kompleksnim poroznim katalizatorima]]></title_hr><title_en><![CDATA[Mechanochemical strategies towards complex porous catalysts]]></title_en><user_id>280</user_id><user_firstLast_name>Krunoslav Užarević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-5083</code><acronim><![CDATA[MECATALYST]]></acronim><duration>31.12.2025 - 30.12.2028</duration><status>U tijeku</status><financ_value>199.992,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, Fizika, </scie_field_hr><scie_field_en>Chemistry, Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>29530, 24767, 13551, 25668, 864960, 21344, 13070, 25568, 870568, 870556, 870047, 870563, 868103, 870614, </team_members_id><team_members_names><![CDATA[Valentina Martinez, Jasna Alić, Igor Dejanović, Tomislav Mrla, Mihails Arhangelskis, Katarina Lisac, Emmerling Franziska, Blaž Likozar, Francesco Carraro, Bramantya Bramantya, Emilija Petrović Hađar, Tina Ročnik Kozmelj, Matjaž Mazaj, Marjorie Musikavanhu, ]]></team_members_names><keywords_hr><![CDATA[Mehanokemija, multivarijantni MOF, derivati ??MOF-74, MOF kompoziti, HOF biokompoziti, zelena kemija, ubrzano starenje, kataliza]]></keywords_hr><keywords_en><![CDATA[Mechanochemistry, Multivariate MOFs, MOF-74 derivatives, MOF composites, HOF biocomposites, Green Chemistry,  Environmental catalysis]]></keywords_en><summary_hr><![CDATA[Ovaj projektni prijedlog ima za cilj unaprijediti sintezu novih nekonvencionalnih anorganskih i poroznih katalitičkih materijala,s fokusom na supramolekulsko-organske mreže (HOF), njihove enzimske biokompozite i četvrtu generaciju metal-organskih mreža (MOF), multivarijatne i kompozitne MOF-ove koji nisu prisutni u literaturi. Iskoristit ćemo inovativne i zelene sintetičke strategije za pripremu ovih materijala, poput naprednih mehanokemijskih reakcija i reakcija starenja. U ovom kontekstu, ključni cilj je dizajn i izgradnja naprednih mehanokemijskih reaktora koji kombiniraju plazmu i mehaničke sile za sintetiziranje koordinativnih i supramolekularnih katalizatora. Ovi će reaktori također transformirati anorganske katalizatore i medije za mljevenje, koji će se procijeniti za katalitičke primjene. Svi će materijali biti podvrgnuti temeljitoj karakterizaciji korištenjem laboratorijskih i sinkrotronskih tehnika te računalnih metoda. Katalitički učinak odabranih materijala procijenit će se za ključne ekološke procese, kao što je redukcija biomase i ugljičnog dioksida, te heterogena kataliza za proizvodnju kemikalija s dodanom vrijednošću. Utvrdit ćemo kinetičke detalje obećavajućih procesa metodama in situ praćenja koristeći sinkrotronsku difrakciju i Ramanovu spektroskopiju. Kako bi se poboljšalo razumijevanje ovih procesa, bit će razvijena nova in situ tehnika praćenja za praćenje sinteze luminiscentnih materijala, koje je izazovno uhvatiti konvencionalnim Raman spektroskopskim pristupima. Materijali s najboljim performansama bit će skalirani do pilot skala korištenjem reaktorske (mlin s bubnjem) ili kontinuirane mehanokemijske proizvodnje ekstruzijom. Projekt uključuje snažnu međunarodnu mrežu suradnika s ekspertizom u naprednim analitičkim i katalitičkim metodama. Mladi istraživači će steći praktično iskustvo i proširiti svoje vještine kroz suradničke razmjene, jačajući svoju konkurentnost u globalnom istraživačkom okruženju.]]></summary_hr><summary_en><![CDATA[This proposal is focused on the synthesis of novel non-conventional inorganic and porous catalytic materials, in the latter explicitly focusing on supramolecular-organic frameworks (HOFs), their enzymatic biocomposites, and fourth-generation metal-organic frameworks (MOFs), multivariate and composite MOFs not present in the literature. We will exploit innovative and green synthetic strategies to prepare these materials, such as advanced mechanochemical and vapor-solid reactions. In this context, a key objective is to design and build advanced mechanochemical reactors that combine plasma and mechanical forces to synthesize the coordinative and supramolecular catalysts. These reactors will also transform inorganic catalysts and milling media, which will be evaluated for catalytic applications. All materials will undergo thorough characterization using laboratory and synchrotron techniques and computational methods. The catalytic performance of selected materials will be assessed for key environmental processes, such as biomass remediation and carbon dioxide reduction, and heterogeneous catalysis to produce added-value chemicals. We will establish the kinetic details of the promising processes by in situ monitoring methods using synchrotron diffraction and Raman spectroscopy. To enhance the understanding of these processes, a novel in situ monitoring technique will be developed to track the luminescent material syntheses, which are challenging to capture with conventional Raman spectroscopic approaches. The best-performing materials will be scaled to pilot scales using batch (drum mill) or continuous mechanochemical processing by extrusion. The project involves a strong international network of collaborators with expertise in advanced analytical and catalytic methods. Young researchers will gain hands-on experience and expand their skills through collaborative exchanges, strengthening their competitiveness in the global research landscape.]]></summary_en></project><project>
<id>17618</id><title_hr><![CDATA[N-glikozilacija alfa-1 kiselog glikoproteina i fibrinogena kao novi biljezi inzulinske rezistencije i povezanih metaboličkih poremećaja]]></title_hr><title_en><![CDATA[N-glycosylation of alpha-1-acid glycoprotein and fibrinogen as novel biomarkers of insulin resistance and associated metabolic disorders]]></title_en><user_id>5952</user_id><user_firstLast_name>Toma Keser</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2025-02</proposal_call><code>UIP-2025-02-4938</code><acronim><![CDATA[Glyco-Metabo-AGP-Fib]]></acronim><duration>19.02.2026 - 18.02.2031</duration><status>U tijeku</status><financ_value>283.905,00 eur</financ_value><scie_area_hr>Interdiciplinarne znanosti, Biomedicina i zdravstvo, Prirodne znanosti, </scie_area_hr><scie_area_en>Interdisciplinary scientific area, Biomedicine and health sciences, Natural sciences, </scie_area_en><scie_field_hr>Interdisciplinarne prirodne znanosti, Kemija, Biologija, Temeljne medicinske znanosti, Kliničke medicinske znanosti, Biotehnologija u biomedicini, </scie_field_hr><scie_field_en>Interdisciplinary natural sciences, Chemistry, Biology, Basic Medical Sciences, Clinical sciences, Biotechnology in Biomedicine, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Farmaceutsko-biokemijski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Pharmacy and Biochemistry]]></institution_en><team_members_id>19627, 870464, </team_members_id><team_members_names><![CDATA[Domagoj Marijančević, Sanja Goreta, ]]></team_members_names><keywords_hr><![CDATA[inzulinska rezistencija, predijabetes, dijabetes, spolni hormoni, N-glikozilacija, biljezi, alfa-1 kiseli glikoprotein, fibrinogen]]></keywords_hr><keywords_en><![CDATA[insulin resistance, prediabetes, diabetes, sex hormones, N-glycosylation, biomarkers, alpha-1-acid glycoprotein, fibrinogen]]></keywords_en><summary_hr><![CDATA[Inzulinska rezistencija (IR) i metabolički sindrom su stanja s  vrlo visokom prevalencijom koja značajno doprinose globalnom teretu metaboličkih bolesti, uključujući dijabetes tipa 2 (T2D) i kardiovaskularne poremećaje. Pronalazak novih pouzdanih biljega za IR mogao bi omogućiti pravovremenu intervenciju i spriječiti progresiju u T2D. N-glikozilacija plazmatskih proteina, osobito promjene u N-glikozilaciji alfa-1 kiselog glikoproteina (AGP) i fibrinogena (Fib), predstavljaju obećavajuće, ali nedovoljno istraženo područje za otkrivanje biljega IR i srodnih stanja.Ovaj projekt ima za cilj primijeniti nedavno razvijene visokoprotočne LC-MS metode za analizu N-glikozilacije AGP-a i Fib-a u dobro okarakteriziranim kliničkim kohortama. Prvo će se optimizirati metoda za visokoprotočnu analizu N-glikozilacije Fib-a kako bi se povećala osjetljivost i detekcija slabo zastupljenih glikoformi. Zatim će se analizirati obrasci N-glikozilacije AGP-a i Fib-a u odnosu na IR, predijabetes i T2D te procijeniti njihova dijagnostička vrijednost. Također će se istražiti odnos između promjena u N-glikozilaciji AGP-a i Fib-a te spolnih hormona, ispitujući kako metabolička disregulacija utječe na obrasce glikozilacije u populaciji s različitim razinama spolnih hormona. Osim toga, istražit će se kako gestacijski dijabetes, poznati čimbenik rizika za kasniji razvoj T2D-a, te pretilost i T2D tijekom trudnoće utječu na N-glikozilacijske obrasce AGP-a i Fib-a.Rezultat projekta bit će identifikacija specifičnih N-glikozilacijskih obilježja AGP-a i Fib-a povezanih s IR, predijabetesom, T2D-om i gestacijskim dijabetesom, što će poslužiti kao temelj za buduće validacijske studije pronađenih biljega te pružiti uvid u ulogu N-glikozilacije AGP-a i Fib-a u patofiziologiji metaboličkih bolesti. U konačnici, ovo istraživanje moglo bi pridonijeti ranijoj dijagnozi i boljoj stratifikaciji rizika, omogućujući učinkovitije strategije prevencije i intervencije.]]></summary_hr><summary_en><![CDATA[Insulin resistance (IR) and metabolic syndrome are highly prevalent conditions that significantly contribute to the global burden of metabolic diseases, including type 2 diabetes (T2D) and cardiovascular disorders. Identifying reliable biomarkers for IR could enable timely intervention and prevent progression to T2D. N-glycosylation of plasma proteins, particularly alpha-1-acid glycoprotein (AGP) and fibrinogen (Fib), represents a promising but underexplored area for the discovery of biomarkers of IR and related conditions.This project aims to apply recently developed high-throughput LC-MS methods to analyze AGP and Fib N-glycosylation in well-characterized clinical cohorts. First, the method for Fib N-glycosylation analysis will be optimized to enhance sensitivity and enable detection of low abundant glycoforms. Next, the N-glycosylation patterns of AGP and Fib will be examined in relation to IR, prediabetes, and T2D, assessing their diagnostic value and potential to enhance the accuracy of current diagnostic procedures. The relationship between changes in N-glycosylation of AGP and Fib and sex hormones will also be investigated, examining how metabolic dysregulation affects glycosylation patterns in populations with different levels of sex hormones. Additionally, the project will explore how gestational diabetes, a known risk factor for the later development of T2D, obesity, and T2D during pregnancy influence AGP and Fib N-glycosylation patterns.The project will identify specific N-glycosylation traits of AGP and Fib associated with IR, prediabetes, T2D, and gestational diabetes, forming a foundation for future validation studies. These findings will offer new insights into the role of AGP and Fib glycosylation in metabolic disease pathophysiology. Ultimately, this research could contribute to earlier diagnosis and improved risk stratification, enabling more effective prevention and intervention strategies.]]></summary_en></project><project>
<id>17621</id><title_hr><![CDATA[Komunikacijski obrasci i informacijske potrebe Hrvata u Čileu, Argentini i Brazilu: hrvatski iseljenički tisak]]></title_hr><title_en><![CDATA[Communication patterns and information needs of Croats in Chile, Argentina and Brazil: Croatian emigrant press]]></title_en><user_id>870063</user_id><user_firstLast_name>Ivana Hebrang Grgić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-1883</code><acronim><![CDATA[ChilAB-HIT]]></acronim><duration>11.12.2025 - 10.12.2028</duration><status>U tijeku</status><financ_value>153.772,80 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Informacijske znanosti, </scie_field_hr><scie_field_en>Information sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>870072, 870084, 866575, 870117, 29336, </team_members_id><team_members_names><![CDATA[Ana Barbarić, Monika Batur, Maria Florencia Luchetti, Jasna Novak Milić, Milan Puh, ]]></team_members_names><keywords_hr><![CDATA[Argentina, Brazil, Čile, hrvatsko iseljeništvo, informacijske potrebe, komunikacijski obrasci, nakladništvo]]></keywords_hr><keywords_en><![CDATA[Argentina, Brazil, Chile, Croatian emigration, information needs, communication patterns, publishing]]></keywords_en><summary_hr><![CDATA[Cilj projekta je istražiti komunikacijske obrasce i informacijske potrebe Hrvata i osoba hrvatskoga porijekla u Argentini, Brazilu i Čileu. Istražit će se objavljene publikacije s naglaskom na staru i rijetku, teško dostupnu ili javnosti nedostupnu građu. Istražit će se i informacijske potrebe osoba hrvatskoga porijekla u ciljanim zemljama. Istraživanja će se provoditi na terenu i online, kombiniranjem kvalitativnih i kvantitativnih metoda. Prikupljeni podaci organizirat će se u skupove metapodatkovnih zapisa te će se izraditi online bibliografske baze podataka koje će poslužiti za detaljnu analizu nakladničkih i uredničkih koncepata. Izradit će se virtualne zbirke odabrane građe. Zbirke će biti dostupne i pretražive u otvoreno dostupnom institucijskom repozitoriju koji osigurava vidljivost, interoperabilnost i trajnu dostupnost. Očekivani rezultati: identificirat će se građa (i metapodaci) koja nije dostupna javnosti, a dio je hrvatske nacionalne baštine; izradit će se interoperabilne otvoreno dostupne online bibliografske baze podataka koje će po prvi puta objediniti nakladničku produkciju Hrvata u ciljanim zemljama; analizirat će se komunikacijski obrasci na temelju objava od prvih publikacija do društvenih mreža; analizirat će se informacijske potrebe na reprezentativnom uzorku ispitanika; oblikovat će se otvoreno dostupne virtualne zbirke građe; omogućit će se otvoreni pristup uz poštivanje svih pravnih propisa; rezultati istraživanja objavit će se u znanstvenim radovima i predstaviti na znanstvenim konferencijama. Na temelju istraživanja, zaključit će se o promjenama komunikacijskih obrazaca i informacijskih potreba osoba hrvatskoga porijekla na ciljanom području od najranijih zabilježenih interakcija do danas. Istraživački podaci, rezultati i publikacije nastale na temelju istraživanja bit će trajno pohranjeni u otvorenom pristupu pa će moći poslužiti za buduća istraživanja.]]></summary_hr><summary_en><![CDATA[The aim of the project is to investigate the communication patterns and information needs of people of Croatian origin in Argentina, Brazil and Chile. Publications will be researched with an emphasis on old and rare or publicly unavailable material. The information needs of people of Croatian origin in the target countries will be investigated. The research will be conducted in the field and online, combining qualitative and quantitative methods. The collected data will be organized into sets of metadata records; online bibliographic databases will be created that will serve for a detailed analysis of publishing and editorial concepts. Virtual collections of selected material will be created. The collections will be accessible and searchable in an openly accessible institutional repository that ensures visibility, interoperability and permanent availability. Expected results: publications (and metadata) that are not publicly available and are part of the Croatian national heritage will be identified; interoperable, openly accessible online bibliographic databases will be created that will systematically present the publishing production of Croats in the target countries for the first time; communication patterns will be analysed based on publications and other communication channels such as social networks; information needs will be analysed on a representative sample of respondents; openly accessible virtual collections will be created; open access will be enabled in accordance with legal regulations; research results will be published in scientific papers and presented at scientific conferences. Based on the research, conclusions will be drawn about changes in communication patterns and information needs of people of Croatian origin in the target area from the earliest recorded interactions to the present. Research data, results and publications created on the basis of the research will be permanently stored in open access for use in future researches.]]></summary_en></project><project>
<id>17636</id><title_hr><![CDATA[Inverzno modeliranje tečenja i pronosa u kršu koristeći Bayesove hijerarhijske fizikalne neuronske mreže]]></title_hr><title_en><![CDATA[Inverse Karst Flow and Transport Modelling based on Hierarchical Bayesian Physics Informed Neural Networks]]></title_en><user_id>6687</user_id><user_firstLast_name>Hrvoje Gotovac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-2921</code><acronim><![CDATA[Karst-H-BPINN]]></acronim><duration>08.12.2025 - 07.12.2028</duration><status>U tijeku</status><financ_value>195.000,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Građevinarstvo, Računarstvo, Temeljne tehničke znanosti, Interdisciplinarne tehničke znanosti, </scie_field_hr><scie_field_en>Civil engineering, Computer sciences, Basic engineering sciences, Interdisciplinary technological sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu Fakultet građevinarstva, arhitekture i geodezije]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Civil Engineering, Architecture and Geodesy]]></institution_en><team_members_id>870557, 6169, 6989, 870569, 13219, 25699, </team_members_id><team_members_names><![CDATA[Mirna Raič, Vedrana Kozulić, Blaž Gotovac, Petra Sušilović, Mijo Nikolić, Ivan Đepina, ]]></team_members_names><keywords_hr><![CDATA[modeliranje tečenja i pronosa u kršu, inverzno modeliranje, PINN, Bayesova karakterizacija nepouzdanosti, izogeometrijska analiza, krški vodonosnici]]></keywords_hr><keywords_en><![CDATA[karst flow and transport modelling, inverse modeling, PINN, Bayesian uncertainty characterization, isogemetric analysis, karst aquifers]]></keywords_en><summary_hr><![CDATA[Krški vodonosnici predstavljaju ranjive vodne resurse koji čine 25% svjetskih resursa podzemnih voda i imaju vrlo kompleksna svojstva koja ih čine prilično različitima od ostalih vodonosnika. Karakterizirani su tečenjem i pronosom između slabo propusne porozne matrice i brzog turbulentnog tečenja u krškim kanalima. Numeričko krško modeliranje s hidrološki integriranim distribuiranim modelima suočeno je s mnogim izazovima, a na skali sliva ograničeno je rješavanjem velikog i  izrazito nelinearnog sustava jednadžbi i nedostatkom ulaznih podataka kao što su distribucija heterogenosti matrice, nesaturirani parametri vodonosnika  ili konfiguracija geometrije mreže krških kanala. Stoga ćemo u ovom projektu razviti jedino održivo rješenje u obliku novog modela inverznog krškog točenja i pronosa  pod nazivom &#39;&#39;Karst H-BPINN&#39;&#39; koristeći Bayesovu karakterizaciju nepouzdanosti i strojno učenje s fizikalnim neuronskim mrežama. PINN će unutar minimizacije funkcije cilja zadovoljiti mjerene podatke kao i fizikalne uvjete  u obliku diferencijalne jednadžbe, početnih i rubnih uvjeta ili geometrijskih i materijalnih zahtjeva. Umjesto klasičnog inverznog PINN modeliranja koje rješava samo pojedinačne optimalne vrijednosti parametra, ovaj Bayesov pristup će transformirati (&#39;&#39;prior&#39;&#39;) prethodno definiranu funkciju gustoće vjerojatnosti (pdf), nepoznatih navedenih fizikalnih i drugih parametara u svoj konačni (&#39;&#39;posterior&#39;&#39;) pdf koji predstavlja analizu svih mogućih stvarnih scenarija za vodne resurse. Karst H-BPINN će se primijeniti na  laboratorijske simulacije u strogo kontroliranim uvjetima, kao i na stvarne krške vodonosnike. Ovaj inovativni pristup pokušava napraviti kompromis između računalnih naprednih tehnologija i realne kvalitete mjerne mreže - monitoringa. Projektni pristup može imati značajan utjecaj na direktive o vodnim resursima u krškim vodonosnicima, podršku donositeljima odluka, poboljšanje postojećeg monitoringa i zadovoljiti strategije zaštite okoliša.]]></summary_hr><summary_en><![CDATA[Karst aquifers provide vulnerable water resources accounting for 25% of the world groundwater resources that have complex properties that make them quite different from the other aquifers. They are characterized by flow, solute and energy transport interchange between low permeable porous matrix and fast turbulent surface flow in the karst conduits. Numerical karst modelling with hydrologically integrated physically based models is faced by many challenges and at the scale of real watersheds are limited by solving huge strongly nonlinear system of equations and missing of input data such as matrix heterogeneity distribution, unsaturated flow parameters or conduit geometry configuration. Therefore, in this project we will develop only viable solution in the form of new inverse karst flow and transport model called Karst H-BPINN using the Bayesian uncertainty characterization and machine learning with Physics Informed Neural Networks. PINN will satisfy inside the loss function sparse data measurements as well as physical constraints in the form of differential equation, initial and boundary conditions or geometric and material requirements. Instead of classical inverse PINN modelling that solve only single optimal parameter values, this Bayesian framework will transform prior predefined probability density function of unknown mentioned physical and other parameters to the posterior pdf representing analysis of all possible real scenarios to the water resources. Karst H-BPINN will be applied to the well-controled laboratory simulations as well as to the real karst aquifers. This innovative approach tries to make trade-off between computational strengths and realistic quality of measurement network. Project approach may have significant impact to water resources directives in karst aquifers, support to decision makers, create basis for improving monitoring and satisfy environmental protection strategies.]]></summary_en></project><project>
<id>17638</id><title_hr><![CDATA[Bis-fosfini kao nemetalni katalizatori za aktivaciju malih molekula - dizajn i sinteza]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3775</user_id><user_firstLast_name>Irena Škorić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-3534</code><acronim><![CDATA[CatDesSyn]]></acronim><duration>11.11.2025 - 10.11.2031</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet kemijskog inženjerstva i tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Chemical Engineering and Technology]]></institution_en><team_members_id>872899</team_members_id><team_members_names><![CDATA[ Doktorand: Karla Bulava ]]></team_members_names><keywords_hr><![CDATA[dizajn katalizatora, nemetalna kataliza, frustrirani Lewisovi parovi, hidričnost, redukcija CO2, aktivacija dušika i metana]]></keywords_hr><keywords_en><![CDATA[catalyst design, metal free catalysis, frustrated Lewis pairs,  hydricity, CO2 reduction, dinitrogen and methane activation]]></keywords_en><summary_hr><![CDATA[Kataliza igra važnu ulogu u gotovo svim granama kemije, stoga je dizajn učinkovitih katalizatora konstantan znanstveni izazov. U suvremenim znanstvenim istraživanjima vezanim uz dizajn katalizatora obično se koristi kombinacija eksperimentalnog i računalnog pristupa jer njihova međusobna sinergija pozitivno utječe na konačni rezultat. Aktivacija malih molekula odgovarajućim katalizatorom prvi je korak mnogih kemijskih transformacija povezanih sa sintezom novih spojeva i materijala. Tijekom posljednjih 60 godina, istraživanja u području organometalne kemije značajno su pridonijela području dizajna katalizatora, nudeći veliki broj visoko reaktivnih i selektivnih spojeva za homogenu katalizu. Međutim, sve veća potreba za ekološki prihvatljivijim alternativama rezultira intenzivnom potragom za nemetalnim katalizatorima, uključujući nemetalne hidridne donore, katalizatore za aktivaciju C-H veze, te aktivaciju N2, CH4 i drugih vrlo stabilnih molekula. Unutar ovog projekta predviđamo da su molekulski sustavi koji se temelje na bisfosfinima koji na atomima fosfora kao supstituente imaju jake elektrondonorske skupine vrlo snažni donori hidrida sposobni reducirati CO2. Nadalje, predviđamo da su ovi sustavi, ako se kombiniraju s jakim Lewisovim kiselinama, sposobni aktivirati dušik (N2) i metan (CH4). Ove hipoteze provjerit će se i potvrditi računalnim modeliranjem. Odabrane molekulske sustave ćemo istražiti eksperimentalno. Razvit ćemo metode za si ntezu perspektivnih bisfosfina, a novosintetizirane spojeve podvrgnut ćemo eksperimentalnoj evaluaciji. Osim znanstvenih rezultata u vidu publikacija u visokorangiranim časopisima, ovaj projekt je važan i jer otvara novi put istraživanja u Hrvatskoj te omogućuje prijenos znanja i ekspertize u području fosfinske kemije kroz sudjelovanje njemačkog partnera u timu. Dodatno, studenti uključeni u projekt steći će dragocjeno profesionalno iskustvo.]]></summary_hr><summary_en><![CDATA[Catalysis plays an important role in almost all branches of chemistry, making the development of efficient catalysts a constant challenge. Both experimental and computational approaches to catalyst design are very active in contemporary research, and their interplay leads to synergistic effects in the final result. The activation of small molecules by a suitable catalyst is the first step of many chemical transformations in the synthesis of new compounds and materials. Over the last 60 years, research in the field of organometallic chemistry has made an important contribution to catalyst design and has produced a large number of highly reactive and selective compounds for homogeneous catalysis. However, the increasing need for more environmentally friendly alternatives leads to an intensive search for metal-free catalysts, including metal-free hydride donors, catalysts for the activation of C-H bonds and the activation of N2, CH4 and other stable molecules. In this project, we propose that molecular systems based on bis-phosphines, in which the substituents on the phosphorus are strong electron-donating groups, are very powerful hydride donors that can reduce CO2. Furthermore, we foresee that these systems in combination with strong Lewis acids are able to activate dinitrogen (N2) and methane (CH4). All these hypotheses will be answered though computational study. Selected molecular systems will undergo experimental studies. Methods for the synthesis of perspective bis-phosphines will be developed and the prepared compounds will be evaluated experimentally. In addition to the scientific results in the form of publications in high-ranking journals, this project is also important because it opens up a new avenue of research in Croatia and enables the transfer of knowledge and expertise in the field of phosphine chemistry through the participation of the team&#39;s German partner. In addition, the students involved in the project will gain valuable professional experience.]]></summary_en></project><project>
<id>17642</id><title_hr><![CDATA[Potencijal i perspektiva restauracije Europske plosnate kamenice u Jadranskom moru]]></title_hr><title_en><![CDATA[]]></title_en><user_id>670</user_id><user_firstLast_name>Daria Ezgeta Balić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-3824</code><acronim><![CDATA[POPOyster]]></acronim><duration>01.11.2025 - 31.10.2030</duration><status>U tijeku</status><financ_value>60,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut za oceanografiju i ribarstvo]]></institution_hr><institution_en><![CDATA[Institute of Oceanography and Fisheries]]></institution_en><team_members_id>868401</team_members_id><team_members_names><![CDATA[ Doktorand: Niko Bujas ]]></team_members_names><keywords_hr><![CDATA[Ostrea edulis, ekologija ishrane kamenice,  reprodukcija kamenice, distribucija ličinki, restauracija staništa kamenice]]></keywords_hr><keywords_en><![CDATA[Ostrea edulis, oyster feeding ecology, oyster reproduction, larvae distribution, oyster habitat restoration]]></keywords_en><summary_hr><![CDATA[U Europi stanje naselja kamenice klasificira se kao loše ili su čak funkcionalno nestale. U slučaju plosnate kamenice O. edulis, to je rezultat sinergijskog učinka visoke stope smrtnosti uzorkovane parazitom  Bonamia ostreae i prekomjernog izlova. S obzirom da kamenice tvore biogene grebene koji imaju važnu ulogu u funkcioniranju ekosustava, u posljednja dva desetljeća uloženo je mnogo napora kako bi se obnovile prirodne populacije i staništa kamenica u svijetu. Iako je na nekim područjima O. edulis potpuno nestala, ova vrsta je još uvijek prisutna u  Jadranu. Međutim, nedavni podaci pokazuju da se brojnost O. edulis u sjevernom Jadranu značajno smanjila tijekom posljednjeg desetljeća. Iako nas činjenica da je ova vrsta još uvijek prisutna u prirodnim populacijama stavlja u pogodniji položaj u usporedbi s drugim regijama, postoji značajni nedostaci o istraživanju prirodnih populacija ove vrste u Jadranu. Stoga POPOyster projekt predstavlja prvu sveobuhvatnu akciju u Jadranskom moru s ciljem identificiranja novih i relevantnih bioloških i ekoloških podataka o prirodnim populacijama O. edulis potrebnih za buduće mjere očuvanja i obnove.POPOyster je multidisciplinarni projekt koji uključuje osnovna biološka istraživanja, ekološke eksperimente, molekularnu biologiju, ribarstvo, fizičku oceanografiju, ekološko modeliranje i znanost o materijalima. Stoga se projekt POPOyster može smatrati prvim korakom prema obnovi prirodnih populacija kamenica u istočnom Jadranu.Ciljevi će se postići:-	analizom trenutnog stanja kamenica u sjevernom Jadranu; -	analizom bioloških i ekoloških svojstava kao što su reprodukcija i ekologija ishrane O. edulis iz prirodne populacije i njihovih ovisnosti o okolišnim čimbenicima; -	analizom strukture hranidbene mreže i trofičkih odnosa s naglaskom na kamenicu O. edulis-	unaprjeđivanjem znanja o prikladnim podlogama za naseljavanje mlađi kamenice.Rezultati projekta bit će objavljeni u šest znanstvenih radova.]]></summary_hr><summary_en><![CDATA[In the European ecoregion, the status of oyster reefs is described as poor or even functionally extinct. In the case of European flat oyster Ostrea edulis, decline is a result of the synergistic effect of the high mortality rate observed in O. edulis due to overfishing and a parasitic disease bonamiosis. Since oysters form biogenic reefs and play an important ecological role in the ecosystem functioning, in the last two decades, significant efforts have been made to restore the native oyster populations and their habitats. Although, O. edulis vanished entirely in some areas, it is still present in the Adriatic. However, recent data also showed that O. edulis abundance in the northern Adriatic decreased significantly during the last decade. Despite having the advantage over other regions, as O. edulis is still present in natural populations, there is a lack of research on natural population of this species in the eastern Adriatic. POPOyster project will serve as a first holistic action in the Adriatic Sea aimed to identify new and relevant biological and ecological data about natural populations of O. edulis necessary for future conservation and restoration measures. POPOyster is a highly multidisciplinary project that includes basic biological research, ecological experiments, molecular biology, fisheries, physical oceanography, ecological modelling, and material science. Therefore, POPOyster can be considered a first step toward restoring natural oyster populations in the eastern Adriatic. This will be achieved by: -analysing the current status of oyster beds in the northern Adriatic; -analysing biological and ecological traits such as reproduction and feeding ecology of O. edulis from natural population and related environmental parameters; -analysing the food web structure and trophic interactions of O. edulis;-improve knowledge about suitable substrates for oyster settlement.Project results will be published in six scientific papers.]]></summary_en></project><project>
<id>17644</id><title_hr><![CDATA[Istraživanje izvan skalarnog sektora standardnog modela na LHC-u ]]></title_hr><title_en><![CDATA[Probing beyond the Standard Model scalar sector at the LHC ]]></title_en><user_id>19738</user_id><user_firstLast_name>Dinko Ferenček</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-4414</code><acronim><![CDATA[PROBE-S]]></acronim><duration>05.12.2025 - 04.12.2028</duration><status>U tijeku</status><financ_value>190.608,85 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>11164, 1086, 19705, 26101, </team_members_id><team_members_names><![CDATA[Vuko Brigljević, Krešimir Jakovčić, Tatjana  Šuša, Tania Robens, ]]></team_members_names><keywords_hr><![CDATA[LHC, detektor CMS, Higgsov bozon, proširenim skalarni sektor standardnog modela, silicijski piksel detector]]></keywords_hr><keywords_en><![CDATA[LHC, CMS detector, Higgs boson, extended scalar sector of the standard model, silicon pixel detector]]></keywords_en><summary_hr><![CDATA[Naše trenutno razumijevanje temeljnih gradivnih blokova materije i njihovih interakcija sažeto je u Standardnom modelu (SM), koji, unatoč svojim uspjesima, ima značajne nedostatke koji upućuju na potrebu za temeljnijom teorijom. Predloženi modeli fizike izvan SM-a (BSM) predviđaju nove pojave koje bi potencijalno mogle biti uočljive na LHC-u, našem glavnom alatu za istraživanje BSM fizike. LHC je započeo svoj treći radni ciklus (Run 3) 2022. godine, radeći pri višim energijama sudara i s ciljem utrostručenja podataka prikupljenih u prethodnim ciklusima do kraja Run 3 sredinom 2026. godine. Iako je otkriće Higgsovog bozona 2012. godine bilo značajno postignuće, potrage za BSM fizikom dale su ograničene rezultate, iako su se pojavila neka odstupanja od SM-a. Kako se LHC približava svojim konačnim energetskim mogućnostima, usredotočujemo se na dvije strategije: istraživanje neistraženih područja i prikupljanje podataka za provjeru uočenih anomalija. Higgsov bozon, ključan za lomljenje elektroslabe simetrije, otvara novi put za potrage BSM fizike, budući da će se BSM fizika vjerojatno vezati s njim. Štoviše, možda nije jedinstven u prirodi jer ne postoji inherentno načelo koje isključuje postojanje dodatnih skalara. Ovaj projekt ima za cilj istražiti nove skalarne čestice kako je predviđeno u proširenim modelima skalarnog sektora SM-a, posebno ciljajući na prilično spektakularno konačno stanje s tri Higgsova bozona koje je nedavno privuklo interes. Opažanje ovog stanja, koje nije moguće postići na LHC-u samo putem SM-a, pružilo bi uvjerljive dokaze za BSM fiziku. Osim toga, provest ćemo fenomenološke studije proširenja skalarnog sektora koji nude kandidate za tamnu tvar. Osiguravanje visokokvalitetnog prikupljanja podataka ključno je za ovaj projekt, što uključuje aktivnosti praćenja i kalibracije kako bi se održalo performanse piksel detektora u eksperimentu CMS. Otkriće proizašlo iz ovog istraživanja moglo bi duboko preoblikovati naše razumijevanje temeljne fizike.]]></summary_hr><summary_en><![CDATA[Our current understanding of the fundamental building blocks of matter and their interactions is encapsulated by the Standard Model (SM), which, despite its successes, has notable shortcomings that suggest the need for a more fundamental theory. Proposed models of physics Beyond the Standard Model (BSM) predict new phenomena potentially observable at the Large Hadron Collider (LHC) at CERN, our prime tool for exploring BSM physics. The LHC began its third running period (Run 3) in 2022, operating at higher collision energies and aimed at tripling data collected from previous runs by the end of Run 3 in mid-2026. While the Higgs boson discovery in 2012 was a landmark achievement, searches for BSM physics have yielded limited results, though some deviations from SM have emerged. With the LHC nearing its ultimate energy capabilities, we focus on two strategies: exploring uncharted territories and accumulating data to verify observed anomalies. The Higgs boson, central to electroweak symmetry breaking, opens a new avenue for BSM searches, as BSM physics is likely to couple with it. Moreover, it may not be unique in nature as there is no inherent principle precluding the existence of additional scalar particles. This project aims to investigate new scalar particles as predicted in extended scalar sector models of the SM, specifically targeting a rather spectacular final state with three Higgs bosons that has garnered recent interest. An observation of this state, unattainable at the LHC via the SM alone, would provide compelling evidence for BSM physics. Additionally, we will conduct phenomenological studies of extensions of the scalar sector that provide dark matter candidates. Ensuring high-quality data collection is crucial for this project, which includes monitoring and calibration activities to maintain the pixel detector&#39;s performance in the CMS experiment. A discovery stemming from this research could profoundly reshape our understanding of fundamental physics.]]></summary_en></project><project>
<id>17648</id><title_hr><![CDATA[Modifikacija strukture i vezne površine biomaterijala i tvrdih zubnih tkiva]]></title_hr><title_en><![CDATA[]]></title_en><user_id>12362</user_id><user_firstLast_name>Ivana Miletić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-9856</code><acronim><![CDATA[MODIBIODENT]]></acronim><duration>12.01.2026 - 11.01.2032</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Dentalna medicina, </scie_field_hr><scie_field_en>Dental medicine, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Stomatološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Dentistry]]></institution_en><team_members_id>873075</team_members_id><team_members_names><![CDATA[ Doktorand: Maria Bota ]]></team_members_names><keywords_hr><![CDATA[biointeraktivni materijali, bioaktivni materijali, restaurativna dentalna medicina, endodoncija, laser]]></keywords_hr><keywords_en><![CDATA[biointeractive materials, biaoctive materials, restorative dental medicine, endodontics, laser ]]></keywords_en><summary_hr><![CDATA[Zubni karijes još uvijek predstavlja globalni problem s prevalencijom u odrasloj populaciji od čak 90%. Uslijed karijesa, dolazi do oštećenja tvrdih zubnih tkiva, cakline i dentina, a nastavkom bolesti i do odumiranja zubne pulpe te potrebe za endodontskim liječenjem. Moderni pristup u terapiji bolesti sve se više temelji na uporabi materijala kojima se nastoji obnoviti oštećena struktura zuba ili potaknuti tkivni odgovor na cijeljenje. Idealni materijal koji bi u potpunosti udovoljio svim zahtjevima još uvijek nije pronađen budući da se pokušava naći balans između optimalnih mehaničkih svojstva te preventivnog i terapijskog djelovanja materijala, a uzimajući u obzir složeno i promjenjivo oralno mikro okruženje. Stoga, cilj ovog projekta je ispitati nove eksperimentalne i komercijalno dostupne biomaterijale u  interakciji s tvrdim zubnim tkivima te utjecaj modifikacije vezne površine tvrdih zubnih tkiva djelovanjem lasera i zračne abrazije na njihovo ponašanje pri dinamičkim uvjetima. Istraživanja će obuhvatiti  dvije skupine materijala: biointeraktivne restuarativne materijale i njihove modifikacije s analozima nekolagenih proteina (NCP) te bioaktivne kalcij-silikatne cemente i njihove modifikacije  NCP i polimerima. Istraživanja ovog projektnog prijedloga pridonijela bi boljem razumijevanju bioloških, kemijskih i mehaničkih svojstava ispitivanih materijala i njihove interakcije  s tvrdim zubnim tkivima kako bi se dale jasne smjernice za odabir najprikladnijih materijala i postupaka za određene kliničke situacije.]]></summary_hr><summary_en><![CDATA[Dental caries still represents a global problem with a prevalence in the adult population of as much as 90%. Caries results in damaged hard dental tissues, enamel and dentin, and with the progression of the disease, dental pulp is affected and endodontic treatment is needed. The modern approach in caries treatment is based on either using the materials for restoration of lost hard dental tissues or stimulating tissue healing. An ideal material that would fully meet all requirements has not yet been found, since the goal is to achieve balance between optimal mechanical properties and the preventive and therapeutic effect of the material, while taking into account the complex and variable oral microenvironment. Therefore, the main objective of this project is to investigate new experimental and commercially available biomaterials in interaction with hard dental tissues and the influence of modification of the bonding surface of hard dental tissues by laser and air abrasion on the behavior of the materials under dynamic conditions. Research will cover two groups of materials: biointeractive restorative materials and their modifications with analogs of non-collagen proteins (NCP) and bioactive calcium-silicate cements and their modifications with NCP and polymers. The research proposed by this project would contribute to a better understanding of the biological, chemical and mechanical properties of the investigated materials and their interaction with hard dental tissues in order to provide clear guidelines for the selection of the most suitable materials and procedures for certain clinical situations.]]></summary_en></project><project>
<id>17649</id><title_hr><![CDATA[CIRCUIT: Holistic approach to foster circular and resilient transport infrastructures and support the deployment of green and innovation public procurement and innovative engineering practices]]></title_hr><title_en><![CDATA[]]></title_en><user_id>2571</user_id><user_firstLast_name>Meho Saša Kovačević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-7272</code><acronim><![CDATA[]]></acronim><duration>01.12.2025 - 30.11.2031</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Građevinarstvo, </scie_field_hr><scie_field_en>Civil engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Građevinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Civil Engineering]]></institution_en><team_members_id>872993</team_members_id><team_members_names><![CDATA[ Doktorand: Martina Pavlović ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>17651</id><title_hr><![CDATA[Zeleni ribarski brodovi]]></title_hr><title_en><![CDATA[Green fishing vessels]]></title_en><user_id>252</user_id><user_firstLast_name>Nikola Vladimir</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-2271</code><acronim><![CDATA[GREEN-FISH]]></acronim><duration>31.12.2025 - 30.12.2028</duration><status>U tijeku</status><financ_value>153.684,72 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Brodogradnja, Interdisciplinarne tehničke znanosti, </scie_field_hr><scie_field_en>Naval architecture, Interdisciplinary technological sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>25263, 25261, 868362, 13308, 868413, 868526, 13468, 870848, 858374, 872879, </team_members_id><team_members_names><![CDATA[Andro Bakica, Maja Perčić, Marija Koričan, Neven Hadžić, Caglar Karatug, Ailong Fan, Momir Sjerić, Ziaul Haque Munim, Ivana Jovanović, Nolla Todorović, ]]></team_members_names><keywords_hr><![CDATA[dekarbonizacija, ribarski brodovi, energetska učinkovitost, tehničke mjere, operativne mjere, tržišne mjere, LCCA, sigurnost]]></keywords_hr><keywords_en><![CDATA[decarbonisation, fishing vessels, energy efficiency, technical measures, operative measures, market-based measures, LCCA, safety]]></keywords_en><summary_hr><![CDATA[Dekarbonizacija pomorskog sektora sastavni je dio ambicioznih ciljeva Pariškog sporazuma, s ciljem smanjenja štetnih utjecaja klimatskih promjena na ekosustave, zajednice i gospodarstva. Brodovi se uglavnom pokreću motorima s unutarnjim izgaranjem na fosilna goriva rezultirajući štetnim emisijama. U posljednje vrijeme u pomorskom sektoru aktualan je niz propisa i s njima povezanih dekarbonizacijskih mjera. Međutim, ove mjere nisu jednako učinkovite za sve brodove. Ribarski brodovi, često karakterizirani zastarjelim nisko učinkovitim pogonskim sustavima, različitošću tehničkih značajki te izrazito nepravilnim operativnim profilima, zahtijevaju posebnu pažnju. Projekt GREEN-FISH rezultirat će planom dekarbonizacije za ribarske brodove u Jadranskom moru kombinirajući suvremene računalne alate i metode potvrđene u drugim povezanim područjima (prekooceanska, priobalna i unutarnja plovidba). GREEN-FISH podrazumijeva detaljnu analizu odabrane ribarske flote, tehničkih karakteristika (iz javnih baza podataka) i operativnih karakteristika brodova (kombinirajući podatke u stvarnom vremenu iz sustava za praćenje flote s 10 ribarskih brodova te integralne godišnje podatke dobivene od ribarskih zadruga). Provest će se niz proračuna kako bi se identificirale održive tehničke, operativne ili tržišne mjere za ribarske brodove. Proširena analiza troškova životnog ciklusa uključivat će buduće scenarije dekarbonizacije te će se kombinirati sa simulacijama budućih cijena goriva i ugljičnog poreza, dok će postojeći emisijski indeksi biti nadograđeni kako bi omogućili usporedbe različitih ribarskih brodova prema ekonomskim i ekološkim kriterijima. Primijenit će se složeni numerički proračuni kako bi se provjerila izvedivost operativnih strategija (npr. upravljanje gazom i trimom, održavanje trupa i sl.) za smanjenje potrošnje goriva i emisija. Naposljetku, bit će ponuđene smjernice za primjenjivost razvijenog plana dekarbonizacije za druge ribarske sektorima diljem svijeta.]]></summary_hr><summary_en><![CDATA[Decarbonisation of the maritime sector is a key component of the ambitious targets of the Paris Agreement to reduce the adverse impacts of climate change on ecosystems, communities, and economies. Ships are mainly powered by internal combustion engines consuming fossil fuels, thus generating adverse emissions. Recently, several regulations and associated decarbonisation measures for maritime operations are being examined. However, these measures are not equally efficient for all ships. Fishing vessels are regularly characterized by aged low-efficient power systems, scattered technical characteristics as well as with highly irregular operative profiles which require special attention. The GREEN-FISH project will result in decarbonisation roadmap for fishing vessels in the Adriatic Sea by combining the most advanced tools and methodologies confirmed in other associated areas (long-distance, short-sea, inland waterway transportation). GREEN-FISH will include detailed analysis of relevant fishing fleet, vessel technical (from public databases) and operative characteristics (by combining real-time data from the fleet monitoring system from 10 fishing vessels and integral data obtained from the fishermen cooperatives). A series of computations will be performed to identify sustainable technical, operative and market-based measures for representative vessels. The extended life-cycle cost analysis (LCCA) will include future decarbonisation scenarios and will be combined with simulations of future fuel and carbon prices, while existing emission indices will be upgraded to offer comparisons of different fishing vessels from the environmental and economic viewpoint. Complex numerical computations will be applied to check viability of operative strategies (e.g. draught and trim management, hull maintenance) in fuel consumption and emission reduction. Finally, guidelines for applicability of the developed decarbonisation roadmap for fisheries sectors worldwide will be offered.]]></summary_en></project><project>
<id>17652</id><title_hr><![CDATA[Divlje i kultivirane Solonaceae vrste: skriveni potencijal kao podloge za plemke rajčice]]></title_hr><title_en><![CDATA[Wild and cultivated Solanaceae species: hidden potentials as rootstock in tomato cultivation]]></title_en><user_id>5091</user_id><user_firstLast_name>Gvozden Dumičić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-2499</code><acronim><![CDATA[WildRootTom]]></acronim><duration>05.12.2025 - 04.12.2028</duration><status>U tijeku</status><financ_value>199.759,62 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Institut za jadranske kulture i melioraciju krša]]></institution_hr><institution_en><![CDATA[Institute for Adriatic Crops and Karst Reclamation in Split]]></institution_en><team_members_id>4176, 27258, 3557, 11213, 250, 865537, 100, 874039, </team_members_id><team_members_names><![CDATA[Branimir Urlić, Angeles Calatayud, Katja Žanić, Olivera Politeo, Ivana Generalić Mekinić, Petra Brzović, Franko Burčul, Dubravka Sandev, ]]></team_members_names><keywords_hr><![CDATA[Cijepljenje rajčice, kompatibilnost, hlapivi spojevi, primarni i sekundarni metaboliti, translokacija dušika]]></keywords_hr><keywords_en><![CDATA[Tomato grafting, kompatibility, volatile compounds, primary and secondary metabolites, nitrogen translocation]]></keywords_en><summary_hr><![CDATA[Klimatske promjene i ljudske aktivnosti, povećavaju uzgoj u zaštićenim prostorima, što u konačnici dovodi do nepovoljnih uvjeta uzgoja i isplativost usjeva. Rajčica (Solanum lycopersicum L.) je jedna od najvažnijih hortikulturnih vrsta i vodeća povrćarska kultura u zaštićenim prostorima. Nepovoljni uvjeti uzgoja predstavljaju ozbiljnu prijetnju rastu biljaka (osobito u zaštićenim prostorima) i sprječavaju biljke da ostvare svoj genetski potencijal, smanjujući prinose i ugrožavajući sigurnost hrane. Cijepljenjem se može smanjiti negativan utjecaj nepovoljnih uvjeta uzgoja na plemke rajčice i time se alternativno održava prinos i kvaliteta plodova. Trenutno je poznato niz komercijalnih podloga, od kojih su većina interspecijski hibridi između S. lycopersicum te: S. habrochaites; S. peruvianum; S. pimpinellifolium ili S. lycopersicum. Iako su brojne podloge dostupne na tržištu, nema dovoljno informacija o kompatibilnosti plemke i podloge. S navedenim podlogama ne možemo riješiti sve sadašnje i buduće proizvodne probleme. Divlje Solanaceae vrste predstavljaju skriveni genetski izvor koji bi mogao riješiti nekoliko problema vezanih uz navedene probleme u proizvodnji rajčice. Plemka pojedine povrtne vrste utječe na konačnu veličinu biljke, prinos i kvalitetu ploda kod cijepljenih biljaka, dok utjecaj podloge može drastično promijeniti te karakteristike. Učinci divljih podloga na gore navedene parametre nisu poznati. Mnoge od Solanaceae vrsta odlikuju se plodovima bogatim spojevima, povoljnim za ljudsko zdravlje. S druge strane većina biljaka iz porodice Solonaceae sadrže alkaloide koji se koriste u farmaceutske svrhe ali mogu biti i vrlo toksični.  Budući da nisu sve kombinacije plemke i podloge prikladne za daljnju proizvodnju i potrošnju, potrebno je pažljivo pratiti morfološke, fizikalno-biokemijske i metaboličke karakteristike biljaka tijekom poljskih pokusa u kontrolnim uvjetima kako bi se izvukla maksimalna korist od cijepljenja za uzgajivače i potrošače.]]></summary_hr><summary_en><![CDATA[Tomato (Solanum lycopersicum) is one of the most important and leading vegetable crops in protected areas. Adverse growing conditions, climate change, pose a serious threat to plant growth and prevent plants from reaching their genetic potential, reducing yields and threatening food security. Grafting can alleviate the negative impact of unfavorable growing conditions on tomato scions and thus provides an alternative way to maintain fruit yield and quality. Currently, there are several commercial tomato rootstocks, most of them are interspecific hybrids between S. lycopersicum and: S. habrochaites, S. peruvianum, S. pimpinellifolium or S. lycopersicum. Although a number of rootstocks are available at market, there is not enough information related to scion–rootstock compatibility. Using these rootstocks, we cannot solve all current and future production problems. Wild Solanaceae species represent a hidden genetic source that could solve several problems related to the abiotic and biotic stresses in tomato production. Although the scion influences final plant size, yield, and fruit quality in grafted plants, the rootstock(s) can also influence/alter these traits. The effects of wild rootstocks on these parameters are not known. Many of the Solanaceae species are characterized by fruits rich in health-promoting substances. On the other hand, most plants in the Solonaceae family contain alkaloids that are/can be used for pharmaceutical purposes, but can also be negative/toxic to human health. Since not all combinations of scion and rootstock are suitable for further production and consumption, it is necessary that we carefully monitor the morphometric, physio-biochemical and metabolic characteristics of the plants during field trials under control conditions in order to obtain the maximum benefit from grafting/rootstocks for growers and consumers.]]></summary_en></project><project>
<id>17662</id><title_hr><![CDATA[Vjerojatnosni i analitički aspekti frakcionalnog Laplaceovog operatora i njegove modifikacije]]></title_hr><title_en><![CDATA[Probabilistic and analytic aspects of the fractional Laplacian and its modifications]]></title_en><user_id>145</user_id><user_firstLast_name>Zoran Vondraček</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-8793</code><acronim><![CDATA[PAAFL]]></acronim><duration>05.12.2025 - 04.12.2028</duration><status>U tijeku</status><financ_value>130.755,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>635, 23258, 867730, 867739, 867735, 867851, 23020, </team_members_id><team_members_names><![CDATA[Vanja Wagner, Ivan Biočić, Ivan Puljiz, Panki Kim, Renming Song, Bruno Toaldo, Moritz Kassmann, ]]></team_members_names><keywords_hr><![CDATA[Frakcionalni Laplaceov operator, nelokalni operatori, Dirichletove forme, Markovljevi procesi, paraboličke jednadžbe]]></keywords_hr><keywords_en><![CDATA[Fractional Laplacian, non-local operators, Dirichlet forms, Markov processes, parabolic equations]]></keywords_en><summary_hr><![CDATA[Nelokalni operatori matematički su alat za modeliranje fizičkih fenomena koji pokazuju nelokalne interakcije, ovisnosti dugog dometa, skokovito ponašanje i učinak prianjanja. Frakcionalni Laplaceov operator je najjednostavniji i najvažniji primjer nelokalnog operatora. To je integralni operator sa singularnom jezgrom koja opada kao potencija. Cilj ovog projekta je proučavanje vjerojatnosnih i analitičkih aspekata frakcionalnog Laplaceovog operatora, njegovih različitih modifikacija i pripadnih jednadžbi. Preciznije, istražit ćemo sljedeće probleme:(i) Frakcionalni Laplaceov operator i degeneracija na granici,(ii) Nelokalne Dirichletove forme regionalnog tipa,(iii) Paraboličke jednadžbe nelokalne u prostoru i vremenu.U prvom dijelu fokus će biti na varijantama frakcionalnog Laplaceovog operatora s jezgrama koje osim interakcija između točaka uključuju i interakcije točaka s granicom prostora stanja. Ovo pokriva i pad i eksploziju jezgre, čineći je degeneriranom na granici. U drugom dijelu proučavat ćemo različite modifikacije frakcionalnog Laplaceovog operatora koristeći Dirichletove forme. U trećem dijelu fokus će biti na nelokalnim modifikacijama lokalne paraboličke jednadžbe. Ovdje ćemo pokriti slučaj nelokalnog u prostoru operatora, nelokalnog u vremenu i nelokalnog u prostoru operatora, te zajednički prostorno-vremenskog nelokalnog operatora.]]></summary_hr><summary_en><![CDATA[Nonlocal operators are a mathematical tool for modeling physical phenomena that exhibit nonlocal interactions, long-range dependencies, jumping behavior, and sticking effects. The fractional Laplacian is the simplest and most important example of a nonlocal operator. It is an integral operator with a singular kernel having the power law decay. The goal of this project is to study the probabilistic and analytical aspects of the fractional Laplace operator, its various modifications, and related equations. More precisely, we will investigate the following problems:(i) Fractional Laplace operator and degeneracy at the boundary,(ii) Nonlocal Dirichlet forms of the regional type,(iii) Parabolic equations non-local in space and time.In the first part, the focus will be on variants of the fractional Laplacian with kernels that, in addition to interactions between points, also include interactions of points with the boundary of the state space. This covers both the decay and explosion of the kernel, making it degenerate at the boundary. In the second part, we will study different modifications of the fractional Laplacian using Dirichlet forms. In the third part, the focus will be on non-local modifications of the local parabolic equation. Here we will cover the case of non-local in space operator, non-local in time and non-local in space operator, and jointly in space-time non-local operator.]]></summary_en></project><project>
<id>17671</id><title_hr><![CDATA[Kosti, izotopi i geni: zdravlje, prehrana i podrijetlo antičkih stanovnika Hrvatske]]></title_hr><title_en><![CDATA[]]></title_en><user_id>2670</user_id><user_firstLast_name>Mario Novak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-4609</code><acronim><![CDATA[AncientRomans]]></acronim><duration>15.10.2025 - 15.10.2030</duration><status>U tijeku</status><financ_value>60,00 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Arheologija, </scie_field_hr><scie_field_en>Archeology, </scie_field_en><institution_hr><![CDATA[Institut za antropologiju]]></institution_hr><institution_en><![CDATA[Institute for Anthropological Research]]></institution_en><team_members_id>869885</team_members_id><team_members_names><![CDATA[ Doktorand: Barbara Kriletic ]]></team_members_names><keywords_hr><![CDATA[Antika, Hrvatska, bioarheologija, trovanje olovom, rekonstrukcija prehrane, drevna DNA]]></keywords_hr><keywords_en><![CDATA[Roman period, Croatia, bioarchaeology, lead poisoning, diet reconstruction, ancient DNA]]></keywords_en><summary_hr><![CDATA[Razdoblje prevlasti Rimskog Carstva na području Europe i Mediterana jedno je od ključnih perioda u povijesnom razvoju ovog dijela svijeta. Strukturne političke, društvene i ekonomske promjene nastale vlašću Rimljana imale su izniman utjecaj na demografsku i populacijsku strukturu lokalnog stanovništva, uvođenje novih prehrambenih navika te pojavu i širenje zaraznih bolesti. Kako bi se dobila jasnija i detaljnija slika o navedenim procesima ovim projektom provest će se sveobuhvatno istraživanje ljudskih ostataka i materijalne kulture s deset antičkih nalazišta iz Hrvatske što uključuje arheološko-kronološku kontekstualizaciju, standardnu bioarheologiju, analizu stabilnih izotopa ugljika i dušika, analizu olova u organizmu te analizu drevne DNA i DNA patogena. Kroz navedeni projekt se po prvi puta sistematski istražuju antičke populacije s prostora Hrvatske na lokalnom i regionalnom nivou koristeći holistički pristup i najmodernije analitičke tehnike, a većina analiza provodi se u laboratorijima u Hrvatskoj. Predloženo istraživanje će iz temelja izmijeniti naše znanje o antičkim stanovnicima Hrvatske što predstavlja izniman korak naprijed u antičkoj arheologiji ne samo u Hrvatskoj već i u širem europskom i mediteranskom kontekstu.  ]]></summary_hr><summary_en><![CDATA[The period of dominance of the Roman Empire in Europe and the Mediterranean is one of the key epochs in the historical development of this part of the world. The structural political, social and economic changes caused by the Roman dominance had a significant impact on the demographic and population structure of the local populations, the changes in dietary habits and the occurrence and spread of infectious diseases. With the aim to obtain a clearer and more detailed picture of these processes this project will conduct a comprehensive study of human remains and material culture from ten Roman period sites from the territory of Croatia including archaeological-chronological contextualization, conventional bioarchaeology, carbon and nitrogen stable isotopes analysis, organism lead level analysis, and ancient DNA and pathogen DNA analyses. This project will for the first time systematically investigate Roman period populations from Croatia at the local and regional levels using a holistic approach and most advanced analytical techniques with most of the analyses carried out in laboratories in Croatia. The proposed study will fundamentally change our knowledge about the Roman period inhabitants of Croatia which represents a huge step forward in Roman period archaeology not only in Croatia, but also in the wider European and Mediterranean contexts.]]></summary_en></project><project>
<id>17676</id><title_hr><![CDATA[Optička dijagnostika infekcija kože]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1485</user_id><user_firstLast_name>Ivan Štajduhar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-7830</code><acronim><![CDATA[OPTIDERM]]></acronim><duration>13.11.2025 - 22.01.2031</duration><status>U tijeku</status><financ_value>62,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Tehnički fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Engineering]]></institution_en><team_members_id>872897</team_members_id><team_members_names><![CDATA[ Doktorand: Darijan Jelušić ]]></team_members_names><keywords_hr><![CDATA[spektralno snimanje, obrada slike, strojno učenje, kolonije bakterija, gljivične kolonije, bakterijski filmovi, kožne infekcije]]></keywords_hr><keywords_en><![CDATA[spectral imaging, image processing, machine learning, bacterial colonies, fungal colonies, bacterial films, skin infections]]></keywords_en><summary_hr><![CDATA[Glavni cilj predloženog istraživanja je olakšavanje uvođenja uređaja za optičko snimanje u kliničku praksu i potpunu laboratorijsku automatizaciju (FLA) radi brže i točnije identifikacije i diferencijacije mikroba infekcija kože i mekog tkiva (SSTI). Specifični ciljevi istraživanja, uključujući kratak opis rada, jesu: (1) Spektralno snimanje SSTI kultura mikroba. Kulture mikroba uobičajenih SSTI-jeva bit će snimane korištenjem VIS-NIR refleksije, fluorescencije i Ramanovog spektralnog snimanja (SI). Za uzgoj mikroba koristit će se različiti supstrati, simulirajući FLA okruženje i stvarne infekcije kože. (2) Spektralno snimanje SSTI in-vivo. Pacijenti oboljeli od SSTI-ja bit će snimljeni korištenjem SI. (3) Razvoj standardiziranih lančanih postupaka za obradu slike. Slike postavljene u bazi podataka stvorenoj s ciljem (4) koristit će se za stvaranje sveobuhvatnog rješenja za automatsku obradu slike (IPPL) radi utvrđivanja optimalne osjetljivosti i specifičnosti identifikacije mikroba SSTI te njihove diferencijacije za FLA i klinički pregled. (4) Stvaranje javno dostupne baze podataka SI slika. Pripremit će se internetsko okruženje baze podataka za pohranu, pristup, upravljanje i dijeljenje spektralnih slika SSTI kultura mikroba (1) i in vivo slika (2).  |  Projekt će uključiti istraživače raznih profesija, sa znanjem i iskustvom u radu s medicinskim hiperspektralnim slikama, mikrobiologiji, obradi medicinskih slika i kliničkoj dermatologiji. Uključene institucije pružit će sve nužno za provedbu predloženog istraživanja: kapacitet za uzgoj mikroba, mogućnost obrade slika, infrastrukturu za pohranu podataka i pristup pacijentima. Rezultati ovog istraživanja, uz standardizaciju sveobuhvatnog lančanog rješenja za obradu spektralnih slika, omogućit će lakšu translaciju tehnologije u kliničku praksu. Razvijena baza podataka spektralnih slika omogućit će i daljnji razvoj novih algoritama za obradu slike od strane šire znanstvene zajednice.]]></summary_hr><summary_en><![CDATA[The main objective of the proposed research is to facilitate translation of optical imaging devices into clinical practise and Full Laboratory Automation (FLA) for a faster and more accurate identification and differentiation of skin and soft tissue infections (SSTI) microbes. Specific objectives of the research, including a brief work description, are: (1) Spectral imaging of SSTI microbe cultures. Microbial cultures of common SSTIs will be imaged using VIS-NIR reflectance, fluorescence and Raman spectral imaging (SI). Different substrates will be used for microbial cultivation, simulating FLA environment and real skin infections. (2) Spectral imaging of SSTI in-vivo. Patients with SSTI will be imaged using SI. (3) Development of standardised image processing pipelines. Images compiled in the database created under objective (4) will be used to create automated image processing pipelines (IPPL) to achieve optimal sensitivity and specificity for identification and differentiation of SSTI microbes for FLA and clinical inspection.(4) Creation of a publicly available database of SI images. An online database environment will be prepared for the storage, access, processing and exchange of spectral images of SSTI microbial cultures (1) and in-vivo images (2). | The project will involve researchers having different backgrounds: medical hyperspectral imaging, microbiology, medical image processing and clinical dermatology. Participating institutions will provide the instrumental, microbial culturing, image processing capabilities, storage infrastructure and patient access needed for the proposed research. The results of this research, including the standardisation of spectral image processing pipelines, will enable a smoother transition of the technology into clinical practise. The database of spectral images developed will enable further development of image processing algorithms by the wider scientific community.]]></summary_en></project><project>
<id>17678</id><title_hr><![CDATA[Improving landslide risk prevention and management in coastal areas (RESONANCE)]]></title_hr><title_en><![CDATA[]]></title_en><user_id>23429</user_id><user_firstLast_name>Josip Peranić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-5685</code><acronim><![CDATA[]]></acronim><duration>15.12.2025 - 14.12.2031</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Građevinarstvo, </scie_field_hr><scie_field_en>Civil engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Građevinski fakultet u Rijeci]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Civil Engineering]]></institution_en><team_members_id>873039</team_members_id><team_members_names><![CDATA[ Doktorand: Josip Zorčić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>17679</id><title_hr><![CDATA[Napredno modeliranje klizišta temeljem karakterizacije tla zasnovane na terenskom monitoringu]]></title_hr><title_en><![CDATA[Advanced Landslide Modelling through Field-Monitoring-Based Soil Characterization]]></title_en><user_id>23429</user_id><user_firstLast_name>Josip Peranić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2025-02</proposal_call><code>UIP-2025-02-6458</code><acronim><![CDATA[ALAMO]]></acronim><duration>19.02.2026 - 18.02.2031</duration><status>U tijeku</status><financ_value>223.438,10 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Građevinarstvo, </scie_field_hr><scie_field_en>Civil engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Građevinski fakultet u Rijeci]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Civil Engineering]]></institution_en><team_members_id>23427, 868506, 866215, 868563, </team_members_id><team_members_names><![CDATA[Martina Vivoda Prodan, Vittoria CAPOBIANCO, Davor Marušić, Alberto Bolla, ]]></team_members_names><keywords_hr><![CDATA[klizišta, nesaturirano tlo, vlažnost tla, sukcija, stabilnost kosina, retencijska krivulja tla, monitoring klizišta]]></keywords_hr><keywords_en><![CDATA[landslides, unsaturated soil, soil moisture, suction, slope stability, soil water retention curve, landslide monitoring]]></keywords_en><summary_hr><![CDATA[Pristupi modeliranju klizišta izazvanih oborinama kojima se razmatra fizika procesa u kosinama, obično se temelje na laboratorijskoj karakterizaciji tla. Međutim, laboratorijski uvjeti pri kojima se mjerenja provode često ne uspijevaju adekvatno replicirati stvarne uvjete na terenu, što dovodi do odstupanja između modeliranog i stvarnog hidromehaničkog odziva kosine in-situ. Ovo istraživanje ima za cilj unaprijediti modeliranje klizišta izazvanih oborinama kroz terensku hidrauličku karakterizaciju tla. Pristup integrira visokokvalitetne terenske podatke i numeričko modeliranje nestacionarnog procesa infiltracije metodom konačnih elemenata, kako bi se analizirao hidromehanički odziv nezasićene zone kosine formirane u sitnozrnastom tlu izložene interakciji između tla, vegetacije i atmosfere. Napredni monitoring sustav uspostavit će se radi prikupljanja podataka o geotehničkim, hidrauličkim i meteorološkim varijablama koje utječu na hidromehaničke uvjete i stabilnost kosina. Primjenom najnoviji tehnoloških dostignuća u području, istraživanje će adresirati ključna znanstvena pitanja u području znanosti o klizištima i in-situ hidromehaničkom odzivu kosina. Akumulirana nova, globalno relevantna znanja u području istraživanja rezultirati će objavljivanjem najmanje pet izvornih znanstvenih radova u vrhunskim međunarodnim časopisima i prezentiranjem rezultata istraživanja na vodećim međunarodnim konferencijama. Projekt će imati i značajan lokalni socioekonomski utjecaj za područje istraživanja, gdje će poboljšanje razumijevanja mehanizama nastanka klizišta doprinijeti učinkovitijem upravljanju rizicima. Ključni ishod projekta biti će uspostava nove istraživačke grupe koja će težiti postati međunarodno priznati centar, fokusiran na najaktualnija pitanja i nadolazeće izazove u području istraživanja klizišta i interakcije tla, vegetacije i atmosfere—tema za koje se očekuje da će s daljnjim globalnim intenziviranjem klimatske krize sve više dobivati na važnosti.]]></summary_hr><summary_en><![CDATA[Physically-based modelling approaches for rainfall-induced landslides typically rely on laboratory-based characterization of soils. However, the laboratory conditions under which measurements are performed often fail to accurately replicate in-situ environments, resulting in discrepancies between predicted and actual hydro-mechanical responses of slopes in the field. This research project aims to improve modelling capabilities of rainfall-induced landslides through a field-based hydraulic characterization. The approach will integrate high-quality field data with finite-element transient seepage modelling to analyse the hydro-mechanical response of the unsaturated zone within fine-grained slopes, driven by the soil-vegetation-atmosphere interaction. An advanced field monitoring system will be established to provide data on geotechnical, hydraulic, and meteorological variables impacting the hydromechanical response and stability condition of slopes. Implementing some of the cutting-edge technological advancements in the field, the research will address some critical scientific questions in landslide science and field hydromechanical response of slopes in general. The outcomes of the research will extend beyond the generation of globally relevant new knowledge in the field, culminating in at least five original research papers published in top-tier international scientific journals and presented at leading international conferences. The project will have a significant local socio-economic impact for the study area, where enhanced understanding of landslide processes can improve risk management practices. A key outcome will be the establishment of a new research group that will aspire to become an internationally recognized centre, which will focus on some of the most actual and emerging challenges in soil-vegetation-atmosphere interaction and landslide research area—topics expected to grow in importance as the global climate crisis intensifies.]]></summary_en></project><project>
<id>17681</id><title_hr><![CDATA[High-Entropy Oxides Photoabsorbers for Efficient and Stable Photoelectrochemical Hydrogen Generation]]></title_hr><title_en><![CDATA[]]></title_en><user_id>11136</user_id><user_firstLast_name>Igor Đerđ</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-1424</code><acronim><![CDATA[]]></acronim><duration>03.12.2025 - 02.12.2031</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Odjel za kemiju]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Department of Chemistry]]></institution_en><team_members_id>872988</team_members_id><team_members_names><![CDATA[ Doktorand: Petra Šušak ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>17682</id><title_hr><![CDATA[Evolucija kvartarnog okoliša Hrvatske arhivirana u spiljskim sedimentima]]></title_hr><title_en><![CDATA[Quaternary Environmental Evolution archived in Croatian Cave Deposits]]></title_en><user_id>1343</user_id><user_firstLast_name>Maša Surić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-6560</code><acronim><![CDATA[QUEECAD]]></acronim><duration>01.12.2025 - 30.11.2028</duration><status>U tijeku</status><financ_value>191.440,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Geologija, </scie_field_hr><scie_field_en>Geology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zadru]]></institution_hr><institution_en><![CDATA[University of Zadar]]></institution_en><team_members_id>865571, 3963, 25947, 1324, 1413, 22775, </team_members_id><team_members_names><![CDATA[Nadja Zupan Hajna, Lara Wacha, Petra Bajo, Robert Lončarić, Neven  Bočić, Tomislav Kurečić, ]]></team_members_names><keywords_hr><![CDATA[promjene u okolišu, kvartar, spilje, sediment, sige, Hrvatska]]></keywords_hr><keywords_en><![CDATA[Environmental changes, Quaternary, caves, sediments, speleothems, Croatia]]></keywords_en><summary_hr><![CDATA[Kvartarne paleookolišne promjene rezultat su, ne samo intenzivno proučavanih paleoklimatskih promjena, već i tektonske aktivnosti, te njihovog uzajamnog utjecaja na geomorfološke procese. Zapisi ovih promjena široko su rasprostranjeni u kršu, točnije u spiljskim sedimentima, ali su u Dinarskom pojasu relativno slabo istraženi. Istraživanja u okviru QUEECAD projekta temelje se na komplementarnosti siga i klastičnih spiljskih sedimenata, s obzirom da je njihova geneza vezana za potpuno različite dinamičke uvjete, odnosno speleogenetske faze. Projektom su obuhvaćene tri lokacije specifičnog geografskog smještaja (spilja Modrič uz jadransku obalu, Cerovačke spilje u masivu Velebita i Baraćeve spilje na sjeveru Like) te položaja (različite nadmorske visine, udaljenosti od mora, geoloških značajki), kako bi se obuhvatio transekt od Sredozemlja preko Dinarida prema središnjoj Europi. Taj istočnojadranski prostor, izložen mediteranskim i sjevernoatlantskim zračnim masama, prolazio je tijekom glacijalnih ciklusa kroz značajne okolišne promjene uz izmjenu dominantnih hidroklimatskih, ali i tektonskih utjecaja, čija će se prostorna i vremenska dimenzija pokušati odrediti ovim istraživanjem. Geokronološki okvir bit će postavljen metodama U-Th, OSL / IRSL te temeljem paleomagnetizma, a multi-proxy pristupom će se objediniti rezultati geokemijskih, mineraloških, i sedimentoloških analiza siga i klastičnih sedimenata. Monitoringom će biti praćena hidroklimatska varijabilnost i međudjelovanje spijskog okoliša i površine radi bolje pouzdanosti paleoklimatske interpretacije i speleogeneze. Osim novih znanstvenih spoznaja, benefiti projekta su i usavršavanje suradnika u eminentnim laboratorijima, uspostava/nastavak višegodišnjeg monitoringa te ujedinjavanje speleoznanstvenog tima.]]></summary_hr><summary_en><![CDATA[Quaternary paleoenvironmental changes are the result, not only of intensively studied palaeoclimate changes, but also of tectonic activity and their mutual influence on geomorphic processes. Records of these changes are widely distributed in karst, specifically in cave sediments, but relatively poorly explored in Dinaric belt. Research within QUEECAD project is based on the complementarity of speleothems and clastic cave sediments, given that their genesis is related to completely different dynamic conditions, i.e. speleogenetic phases. The project encompasses three caves specific by geographical locations (Modrič Cave on the Adriatic coast, Cerovačke Caves in Velebit Mt. and Baraćeve Caves in northernmost part of Lika) and by positions (different altitudes, distance from the sea and geological setting) in order to cover the transect from Mediterranean via Dinarides towards central Europe. This eastern Adriatic realm, exposed to both North Atlantic and Mediterranean air masses, has experienced significant environmental changes during the glacial cycles along with changes in dominant hydroclimatic and tectonic influences, the spatial and temporal dimensions of which will be determined by this research. The geochronological framework will be determined by U-Th and OSL / IRSL dating and by palaeomagnetism, and based on multi-proxy approach, the results of geochemical, mineralogical and sedimentological analyses of speleothem and clastic sediments samples will be comprehended. Monitoring of hydroclimate variability and the cave-surface interaction will ensure reliable palaeoclimate and speleogenesis interpretation. In addition to new scientific knowledge, the benefits of the project are trainings at the eminent laboratories, establishment of multi-year monitoring programs and capacity building of the cave research group.]]></summary_en></project><project>
<id>17683</id><title_hr><![CDATA[Turizam 5.0: zadovoljstvo korisnika kroz digitalnu transformaciju turističke destinacije]]></title_hr><title_en><![CDATA[Tourism 5.0: Customer Satisfaction through Digital Transformation of the Tourist Destination]]></title_en><user_id>867783</user_id><user_firstLast_name>Berislav Andrlić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-1899</code><acronim><![CDATA[T5.0]]></acronim><duration>05.12.2025 - 04.12.2028</duration><status>U tijeku</status><financ_value>98.280,00 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, Informacijske znanosti, </scie_field_hr><scie_field_en>Economy, Information sciences, </scie_field_en><institution_hr><![CDATA[Ništa od navedenog]]></institution_hr><institution_en><![CDATA[Nothing from this list]]></institution_en><team_members_id>865939, 13287, 868049, 870488, </team_members_id><team_members_names><![CDATA[Marko Šostar, Antun Biloš, Vladimir Ristanović, Mahir Zajmović, ]]></team_members_names><keywords_hr><![CDATA[Turizam, marketing, zadovoljstvo potrošača, menadžment turističke destinacije, digitalna transformacija]]></keywords_hr><keywords_en><![CDATA[Tourism, marketing, consumer satisfaction, tourist destination management, digital transformation]]></keywords_en><summary_hr><![CDATA[Projekt &#39;&#39;Turizam 5.0: zadovoljstvo korisnika kroz digitalnu transformaciju turističke destinacije&#39;&#39; (akronim T5.0), usmjeren je na istraživanje utjecaja digitalnih tehnologija na turističke destinacije i iskustvo korisnika. Cilj projekta je stvoriti model SERVQUAL Tourism 5.0, koji bi integrirao napredne digitalne tehnologije za povećanje konkurentnosti i zadovoljstva turista, kao i zaposlenika u turizmu. U okviru projekta, posebna pažnja posvećuje se trenutnom stanju na tržištu digitalnih tehnologija u turizmu, koje pokazuje brzu transformaciju kako destinacija tako i korisničkog iskustva. Digitalne tehnologije, poput virtualnih tura, augmented reality tehnologije, big data, i IoT, ključne su u privlačenju i zadržavanju turista te pružanju realnih informacija koje korisnicima olakšavaju odlučivanje o putovanjima. Osim toga, pružatelji turističkih usluga koriste big data analitiku i Internet stvari za optimizaciju operacija i poboljšanje korisničke službe. Istraživački dio projekta uključuje analizu kako digitalne tehnologije utječu na korisničko iskustvo i ponašanje potrošača, s posebnim naglaskom na socio-ekonomske i demografske karakteristike turista. Također, istražit će se uloga digitalnih tehnologija u operativnoj učinkovitosti turističkih destinacija te kako se tehnologije mogu iskoristiti za održivost destinacija. Projekt T5.0 značajan je zbog svoje multidisciplinarne i interdisciplinarne prirode, uključujući suradnju s vladinim agencijama, turističkim organizacijama, akademskom zajednicom i industrijom. Očekuje se da će rezultati projekta doprinijeti boljem razumijevanju utjecaja digitalne transformacije na turizam te pružiti smjernice za postizanje održivog razvoja turističkih destinacija.]]></summary_hr><summary_en><![CDATA[The project &#39;&#39;Tourism 5.0: User Satisfaction through Digital Transformation of Tourist Destinations&#39;&#39; (acronym T5.0) focuses on researching the impact of digital technologies on tourist destinations and user experiences. The project&#39;s goal is to develop the SERVQUAL Tourism 5.0 model, integrating advanced digital technologies to enhance the competitiveness and satisfaction of both tourists and tourism employees. As part of the project, special attention is given to the current state of digital technologies in the tourism market, which is undergoing rapid transformation in both destinations and user experiences. Digital technologies such as virtual tours, augmented reality (AR), big data, and the Internet of Things (IoT) play a crucial role in attracting and retaining tourists, as well as providing real-time information that facilitates travel decision-making. Additionally, tourism service providers leverage big data analytics and IoT to optimize operations and improve customer service. The research component of the project analyzes how digital technologies influence user experiences and consumer behavior, with a particular focus on the socio-economic and demographic characteristics of tourists. Furthermore, the study will examine the role of digital technologies in the operational efficiency of tourist destinations and how they can be utilized to promote destination sustainability. The T5.0 project is significant due to its multidisciplinary and interdisciplinary nature, involving collaboration with government agencies, tourism organizations, the academic community, and the industry. The expected project outcomes will contribute to a better understanding of the impact of digital transformation on tourism and provide guidelines for achieving the sustainable development of tourist destinations.]]></summary_en></project><project>
<id>17684</id><title_hr><![CDATA[Singularna perturbacija i asimptotička analiza rubnih problema za parcijalne diferencijalne jednadžbe]]></title_hr><title_en><![CDATA[]]></title_en><user_id>22664</user_id><user_firstLast_name>Marko Radulović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-9413</code><acronim><![CDATA[]]></acronim><duration>15.12.2025 - 14.12.2031</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>872968</team_members_id><team_members_names><![CDATA[ Doktorand: Jelena Dujella ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>17687</id><title_hr><![CDATA[Napredno pročišćavanje otpadnih voda prenamjenom biougljena dobivenog iz mulja s uređaja za pročišćavanje]]></title_hr><title_en><![CDATA[Advanced Wastewater Treatment by Repurposing Sewage Sludge Derived Biochar]]></title_en><user_id>17785</user_id><user_firstLast_name>Domagoj Nakić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2025-02</proposal_call><code>UIP-2025-02-9907</code><acronim><![CDATA[AdSorB]]></acronim><duration>01.04.2026 - 31.03.2031</duration><status>U tijeku</status><financ_value>299.950,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Građevinarstvo, Kemijsko inženjerstvo, Interdisciplinarne tehničke znanosti, </scie_field_hr><scie_field_en>Civil engineering, Chemical engineering, Interdisciplinary technological sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Građevinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Civil Engineering]]></institution_en><team_members_id>864937, 20856, 866747, 19717, 17806, 870164, 870247, </team_members_id><team_members_names><![CDATA[Hana Posavčić, Matija Cvetnić, Marko Šrajbek, Krešimir Maldini, Martina Grubor, Anita Leovac Maćerak, Danica Maljković, ]]></team_members_names><keywords_hr><![CDATA[uplinjavanje mulja, biougljen, adsorpcija, napredno pročišćavanje voda, uklanjanje mikroonečišćivala i hranjiva, protočni filter, cementni kompoziti]]></keywords_hr><keywords_en><![CDATA[sewage sludge gasifiction, biochar, adsorption, advanced WWT, micropollutants  and nutrients removal, flow-through filter, cement composites]]></keywords_en><summary_hr><![CDATA[Sve veće količine mulja generiranog na uređajima za pročišćavanje otpadnih voda, kao i onečišćenje voda, posebice uzrokovano mikroonečišćivalima i hranjivima, predstavljaju rastuće globalne ekološke izazove. Projekt AdSorB povezuje ove probleme istražujući primjenu biougljena dobivenog uplinjavanjem mulja kao adsorbensa u naprednom pročišćavanju otpadnih voda. Cilj je ispitati svojstva biougljena i njegovu učinkovitost u uklanjanju različitih onečišćivala (teški metali, hranjiva, farmaceutici, pesticidi) uz optimizaciju procesnih parametara, nakon čega će se procijeniti mogućnost njegove daljnje prenamjene u građevinskoj industriji. Nakon karakterizacije biougljena, provest će se šaržni (batch) testovi kako bi se odredio utjecaj ključnih parametara, rizik sekundarnog onečišćenja te mogućnost višecikličke upotrebe do iscrpljenja adsorpcijskog kapaciteta. Testiranja će se provesti na sintetskim i stvarnim otpadnim vodama. Temeljem dobivenih rezultata, dizajnirat će se protočni kolonski filtar s ispunom od biougljena te će se ispitati njegova učinkovitost uklanjanja ciljnih onečišćivala pri različitim procesnim uvjetima, posebice uz varijaciju protoka i debljine adsorpcijskog sloja. Razvit će se prediktivni model, temeljen na analitičkim izrazima ili numeričkom modeliranju, ovisno o dobivenim rezultatima. Potom će se ispitati mogućnost primjene biougljena s iscrpljenim adsorpcijskim kapacitetom kao djelomične zamjene agregata i/ili cementa u cementnim kompozitima. Istraživanje će se usmjeriti na mehanička i trajnosna svojstva, s posebnim naglaskom na procjenu utjecaja na okoliš kako bi se osigurala sigurnost primjene i identificirali mogući ograničavajući čimbenici. Očekivani rezultati projekta pridonijet će unaprjeđenju zaštite okoliša i održivom upravljanju resursima kroz prenamjenu otpada, inovativnu primjenu biougljena u pročišćavanju otpadnih voda te smanjenje eksploatacije sirovina, čime se sveobuhvatno podupire tranzicija ka kružnom gospodarstvu.]]></summary_hr><summary_en><![CDATA[The growing amounts of sewage sludge and water pollution, particularly from micropollutants and nutrients, pose significant global environmental challenges. The AdSorB project addresses both issues by exploring biochar from sewage sludge gasification as an adsorbent in advanced wastewater treatment. The project aims to investigate the properties of biochar and its efficiency in removing various pollutants (heavy metals, nutrients, pharmaceuticals and pesticides) from wastewater while optimizing process parameters, followed by assessing its feasibility for further utilization in the construction industry. Following biochar characterization, batch tests will be conducted to evaluate the influence of key parameters, the risk of secondary pollution, and the feasibility of multi-cycle use until the adsorption capacity is exhausted, with tests performed on both synthetic and real wastewater samples. Based on the obtained results, a flow-through column filter filled with biochar will be designed and tested for its efficiency in removing selected pollutants under varying process conditions, particularly flow rate and adsorbent layer thickness. A predictive model will be developed, either using analytical expressions or numerical modeling, depending on the complexity of the results. Then, the feasibility of using biochar with exhausted adsorption capacity as a partial replacement for aggregates and/or cement in cement composites will be assessed. The investigation will focus on the mechanical and durability properties, with particular emphasis on assessing their environmental impact to ensure safety of use and identify potential limiting factors. The expected outcomes of the project will contribute to environmental protection and sustainable resource management by repurposing waste, promoting innovative biochar applications in wastewater treatment, and limiting the exploitation of natural resources, thereby comprehensively supporting the transition to a circular economy.]]></summary_en></project><project>
<id>17692</id><title_hr><![CDATA[Mehanizmi dugotrajnog preživljavanja Francisella unutar ameba]]></title_hr><title_en><![CDATA[]]></title_en><user_id>114</user_id><user_firstLast_name>Marina Šantić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-7559</code><acronim><![CDATA[FranAm]]></acronim><duration>26.01.2026 - 25.01.2032</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Clinical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Medicine]]></institution_en><team_members_id>873093</team_members_id><team_members_names><![CDATA[ Doktorand: Vedrana Nefat ]]></team_members_names><keywords_hr><![CDATA[Francisella, ameba, cista, unutarstanični profil, in vivo]]></keywords_hr><keywords_en><![CDATA[Francisella, amoeba, cyst, intracellular profile, in vivo]]></keywords_en><summary_hr><![CDATA[Francisella tularensis je gram-negativna bakterija, uzročnik zoonotske bolesti tularemije. Tularemija je prijavljena prvenstveno u područjima u blizini raznolikih voda. Naša i druga in vitro istraživanja pokazala su da se F. tularensis subsp. tularensis, F. holarctica i F. novicida razmnožavaju u Acanthamoeba castellanii i Hartmannella vermiformis, čineći amebe važnim okolišnim rezervoarom ovih bakterija. Međutim, nije poznato koliko dugo Francisella može preživjeti u amebnim cistama kao ni mehanizmi preživljavanja i oporavka u stanicama sisavaca. Pretpostavljamo da proces transformacije ameba iz stadija trofozoita u ciste u potpunosti regulira Francisella. Očekujemo da ćemo odrediti optimalne uvjete za oporavak bakterija iz cista u različitim hranidbenim uvjetima, stanicama sisavaca i u modelu miša. Nadalje, cilj nam je na modelu miša utvrditi hoće li Francisella uzgojena u amebnoj cisti izazvati pojačani ili smanjeni imunološki odgovor. Na temelju naših preliminarnih rezultata, očekujemo pokazati da Francisella odgađa apoptozu ameba i pokreće proces autofagije u svrhu dugotrajnog preživljavanja u cistama. Proteomske analize koristit ćemo za proučavanje fenotipa Francisella koji se mijenja tijekom transformacije ameba iz trofozoita u cistu. Za razumijevanje promjena u ekspresiji gena tijekom životnog ciklusa Francisella u amebama koristit će se nova metoda transkriptomike. Tri vrste francisela, Francisella tularensis subsp. holarctica soj LVS, F. philomiragia i F. novicida te A. castellanii koristit će se u ovom istraživanju. U predloženom projektu kombinirat ćemo napredne tehnologije kako bismo opisali i identificirali nove čimbenike virulencije Francisella na temelju njihovog unutarstaničnog životnog ciklusa u amebama (trofozoit/cista) koji omogućavaju bakterijama uspješnu infekciju stanica sisavaca. Projekt će doprinijeti povećanju broja visokokvalificiranih mladih istraživača iskusnih u radu s ovim infektivnim i važnim javnozdravstvenim patogenima. ]]></summary_hr><summary_en><![CDATA[Francisella tularensis is a gram-negative bacterium, the causative agent of the zoonotic disease tularemia. Tularemia has been reported primarily in areas near water sources. Our and other in vitro studies have shown that F. tularensis subsp. tularensis, F. holarctica, and F. novicida can replicate in Acanthamoeba castellanii and Hartmannella vermiformis, making amoebae an important environmental reservoir for bacteria. However, it is not known for how long Francisella can survive in amoebae cysts and the mechanisms of survival and recovery in mammalian cells. We hypothesize that the process of transformation of amoebae from the trophozoite stage to cysts is regulated entirely by Francisella. We expect to find the optimal conditions for recovery of bacteria from cysts in different conditions. Our goal is to determine, in mice model, whether Francisella cultured in an amoeba cyst would elicit an enhanced or reduced immunological response. Based on our preliminary results, we expect to demonstrate that Francisella species postpone apoptosis and initiate the autophagy cycle for long-term survival in cysts. In addition, we will apply the proteomic approach to study the phenotype of Francisella that changes as the amoebae transforms from trophozoite to cyst. To understand the changes in gene expression throughout the life cycle of Francisella in amoebae, the novel method of transcriptomics will be used. Three Francisella species, Francisella tularensis subsp. holarctica strain LVS, F. philomiragia and F. novicida and A. castellanii will be included in this study. In the proposed project, we will combine advanced techniques to identify novel virulence factors of Francisella based on their intracellular life in amoebae/cysts for successful infection cycle in mammalians. The project will help increase the number of highly qualified young researchers with experience working with emergent infectious and important public health pathogens. ]]></summary_en></project><project>
<id>17695</id><title_hr><![CDATA[Vatra svjetlo, led, i tlak (FLIP) - Razvoj  metoda procjene mišićne dobi i istraživanje utjecaja specifičnih protokola na biomarkere starenja]]></title_hr><title_en><![CDATA[Fire, Light, Ice, and Pressure (FLIP) – Development of Methods for Assessing Muscle Age and Research on the Effects of Specific Protocols on Aging Biomarkers]]></title_en><user_id>784</user_id><user_firstLast_name>Dražen Čular</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-8546</code><acronim><![CDATA[FLIP]]></acronim><duration>20.12.2025 - 19.12.2028</duration><status>U tijeku</status><financ_value>199.937,00 eur</financ_value><scie_area_hr>Društvene znanosti, Biomedicina i zdravstvo, Biotehničke znanosti, </scie_area_hr><scie_area_en>Social sciences, Biomedicine and health sciences, Biotechnical sciences, </scie_area_en><scie_field_hr>Kineziologija, Temeljne medicinske znanosti, Javno zdravstvo i zdravstvena zaštita, Biotehnologija u biomedicini, </scie_field_hr><scie_field_en>Kinesiology, Basic Medical Sciences, Public health and health services, Biotechnology in Biomedicine, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Kineziološki fakultet]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Kinesiology]]></institution_en><team_members_id>866696, 870534, 1253, 19053, 4560, 868094, 18978, 870790, 865174, 25482, 26409, 3813, </team_members_id><team_members_names><![CDATA[Tea Gutović, Kristina Drole, Ana Kezić, Marijana Čavala, Vladimir Ivančev, Armin Paravlic, Johnny Padulo, Tomislav Dolušić, Matej Babić, Ivica Zelić, Nina Šimunić Briški, Tea Bešlija, ]]></team_members_names><keywords_hr><![CDATA[Starenje mišića, biomarkeri, fiziološki nadzor, nosiva tehnologija, crveno svjetlo, infracrvena sauna, hiperbarična terapija]]></keywords_hr><keywords_en><![CDATA[Muscle aging, biomarkers, physiological monitoring, wearable technology, cold water immersion, red light therapy, infrared sauna, hyperbaric  therapy]]></keywords_en><summary_hr><![CDATA[Starenje je složen biološki proces pod utjecajem genetskih, okolišnih i životnih čimbenika, pri čemu mišićno tkivo s vremenom pokazuje progresivno funkcionalno propadanje. Projekt FLIP usmjeren je na razvoj inovativnih metoda za procjenu mišićne dobi i evaluaciju učinaka ciljnih intervencija: uranjanja u hladnu vodu, infracrvene saune, terapije crvenim svjetlom i hiperbarične oksigenoterapije (HBOT), na biomarkere starenja.  Ključni ciljevi uključuju:1.Uspostavu Hrvatskog Laboratorija za dugovječnost i zdravlje, 2.Analizu povezanost biomarkera starenja i funkcionalnih pokazatelja skeletne muskulature. 3. Usporedbu između različitih skupina ispitanika uključujući i parove blizanaca, kako bi se istražili genetski i okolišni čimbenici starenja. 4.Procijenu učinaka specifičnih protokola na karakteristike mišićnog tkiva i biomarkere starenja. 5. Unaprijeđenje metodologije procjene mišićne dobi primjenom suvremenih instrumenata, statističkih metoda i specifičnih protokola. Ova longitudinalna, eksperimentalna i interdisciplinarna studija kombinira analizu bioloških uzoraka, testiranje neuromišićne funkcije i kontinuirano fiziološko praćenje kako bi se istražiila inamika starenja mišića. Koristit će se napredni dijagnostički alati, uključujući TMG, EMG, MyotonPRO, KINVENT, BauSport Sonicbone, termografiju i Bodyscanner, uz procjenu biološke dobi iz uzoraka krvi i sline. Psihološke i sociološke analize dodatno će istražiti ulogu mentalnih i društvenih čimbenika u procesu starenja. FLIP teži uspostavi standardiziranog okvira za procjenu mišićne dobi, povećanju dijagnostičke preciznosti i istraživanju utjecaja ciljanih  intervencija namijenjenih  usporavanju procesa starenja. Rezultati će imati značajne implikacije za sportsku znanost, rehabilitaciju i preventivnu medicinu, povezujući sportsku fiziologiju, biomedicinu i biotehnologiju. Promicanjem dugovječnosti, FLIP nastoji optimizirati sportsku izvedbu te produžiti trajanje i kvalitetu sportskih karijera i općeg zdravlja.]]></summary_hr><summary_en><![CDATA[Aging is a multifaceted biological process influenced by genetic, environmental, and lifestyle factors, with muscle tissue exhibiting a progressive functional decline over time. The FLIP project aims to develop innovative methods for assessing muscle age and evaluating the effects of targeted interventions (cold water immersion, infrared sauna red light and hyperbaric oxygen therapy-HBOT on aging biomarkers. Key objectives include: 1.Establishment of the Croatian Laboratory for Longevity and Health, 2.Analyze the relationship between aging biomarkers and muscle function, 3.Compare data among different participant groups, including twin pairs to investigate genetic and environmental factors influencing aging. 4.Assess the effects of specific therapeutic protocols on muscle tissue and aging biomarkers. 5.Improve the methodology for assessing muscle age by using modern diagnostic instruments and specific protocols. This longitudinal, experimental, and interdisciplinary study integrates biological sample analysis, neuromuscular function testing, and real-time physiological monitoring to capture muscle aging dynamics. Cutting-edge assessment tools, such as TMG, EMG, MyotonPRO, KINVENT, Sonicbone, Thermography, and Bodyscanner, will be utilized, alongside measuring the epigenetic clock using blood and saliva samples. Psychological and sociological evaluations will further explore the influence of mental and social factors on aging. FLIP aims to establish a standardized framework for muscle age assessment, enhance diagnostic precision, and provide new insights into targeted anti-aging interventions. The findings will have significant implications for sports science, rehabilitation, and preventive healthcare, bridging sports physiology, biomedicine, and biotechnology. By promoting longevity, FLIP aspires to optimize athletic performance and extend the duration and quality of both professional sports careers and overall well-being.]]></summary_en></project><project>
<id>17701</id><title_hr><![CDATA[Neproteinogene aminokiseline za povećanje konformacijske raznolikosti peptida]]></title_hr><title_en><![CDATA[]]></title_en><user_id>66</user_id><user_firstLast_name>IVANKA JERIĆ</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-8744</code><acronim><![CDATA[INCONDI]]></acronim><duration>19.01.2026 - 18.01.2031</duration><status>U tijeku</status><financ_value>60,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>873056</team_members_id><team_members_names><![CDATA[ Doktorand: David Šterpin ]]></team_members_names><keywords_hr><![CDATA[peptides, non-proteinogenic amino acids, synthesis, secondary structures, non-covalent interactions]]></keywords_hr><keywords_en><![CDATA[peptidi, neproteinogene aminokiseline, sinteza, sekundarne strukture, nekovalentne interakcije]]></keywords_en><summary_hr><![CDATA[Procjenjuje se da je oko 800 neproteinogenih aminokiselina (NPAAs)  identificirano u bakterijama, gljivama, biljkama i morskim organizmima, ostavljajući 20 proteinogenih aminokiselina u manjini od 4%. Postojanje mnogo stotina biološki aktivnih prirodnih peptida s jednom ili više NPAA, odražava sposobnost ovih posebnih monomera da daju neka korisna funkcionalna svojstva, koja nisu dostupna u osnovnom skupu od 20 aminokiselina.  NPAAs su svestrani intermedijeri u organskoj sintezi, posebno u razvoju lijekova i intenzivno se koriste u sintezi katalizatora i funkcionalnih materijala. Široka primjenjivost NPAAs čini ih stoga jednom od najvažnijih skupina organskih molekula. S obzirom na njihovu  važnost i široku primjenu, postoji snažna motivacija za pripravu različitih vrsta NPAAs. Mnoge klase NPAAs ostaju neiskorištene zbog nepostojanja sintetskog protokola za njihovu pripravu i/ili dovoljno znanja o njihovom utjecaju na strukturna svojstva molekule u koju su ugrađeni. Da bi doprinijeli rješavanju ovih nedostataka, ovaj projekt ima za cilj proširiti kemijski prostor NPAAs koje bi mogle modulirati konformaciju peptida na definiran i predvidljiv način. To će se postići: (i) sintezom NPAAs izvedenih iz ugljikohidrata, karbašećera i dušikovih heterocikličkih spojeva, (ii) sintezom peptida s ugrađenim NPAAs i njihovom strukturnom karakterizacijom, i (iii) određivanjem nekovalentnih interakcija koje uključuju NPAAs, a koje su odgovorne za usvajanje određene sekundarne strukture. Inspiracija za NPAAs je nađena u prirodnim spojevima opremljenim dobro definiranim trodimenzionalnim strukturama. Predviđena metodologija temelji se na kemijskoj transformaciji ugljikohidrata, karbašećera i dušikovih heterocikličkih spojeva u odgovarajuće aminokiseline. Predviđamo da će peptidi s takvim NPAAs poprimiti konformacijski različite 3D strukture. Planiramo utvrditi ulogu strukture, stereokemije i nekovalentnih interakcija odgovornih za njihovu stabilizaciju.]]></summary_hr><summary_en><![CDATA[It is estimated that about 800 non-proteinogenic amino acids (NPAAs)  have been identified in bacteria, fungi, plants and marine organisms, leaving the 20 proteinogenic amino acids in the minority at 4%.  The prevalence of biologically active natural peptides with one or more NPAAs, reflects the ability of these particular monomers to confer some useful functional properties, not available in the basic set of 20 amino acids. NPAAs are versatile intermediates in organic synthesis, especially in drug discovery and are extensively used in the synthesis of catalysts, and functional materials. Given the importance and application of NPAAs, there is a strong impetus to access various collections of NPAAs. Many classes of NPAAs remain unexploited due to a lack of a synthetic protocol and/or sufficient knowledge about their influence on the structural properties of the molecule into which they are incorporated. Addressing these issues, this project aims to expand the chemical space of NPAAs that could modulate peptide conformation in a defined and predictable way. This will be achieved by: (i) the synthesis of NPAAs derived from carbohydrates, carbasugars and nitrogen containing heterocycles, (ii) the synthesis of peptides with incorporated NPAAs and their structural characterization, and (iii) the determination of the non-covalent interactions involving NPAAs that are responsible for the adoption of a particular secondary structure. The inspiration for  NPAAs is found in natural compounds equipped with well-defined three-dimensional scaffolds. The envisaged methodology is based on the chemical transformation of carbohydrates, carbasugars and nitrogen heterocyclic compounds into related amino acids.  We anticipate that peptides with such NPAAs  will adopt conformationally distinct 3D structures. We plan to determine the role of structure, stereochemistry and non-covalent interactions responsible for their stabilization.]]></summary_en></project><project>
<id>17710</id><title_hr><![CDATA[TERMO-SEIZMIČKA IZOLACIJA: EKSPERIMENTALNO ISPITIVANJE I NUMERIČKO MODELIRANJE]]></title_hr><title_en><![CDATA[THERMO-SEISMIC ISOLATION: EXPERIMENTAL TESTING AND NUMERICAL MODELING]]></title_en><user_id>19464</user_id><user_firstLast_name>Ivan Banović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2025-02</proposal_call><code>UIP-2025-02-2011</code><acronim><![CDATA[THERMO&SEISMIC]]></acronim><duration>01.04.2026 - 31.03.2031</duration><status>U tijeku</status><financ_value>279.155,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Građevinarstvo, </scie_field_hr><scie_field_en>Civil engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu Fakultet građevinarstva, arhitekture i geodezije]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Civil Engineering, Architecture and Geodesy]]></institution_en><team_members_id>19789, 17887, 870005, </team_members_id><team_members_names><![CDATA[Marina Nikolić, Luka Malenica, Igor Tomić, ]]></team_members_names><keywords_hr><![CDATA[geotehnička seizmička izolacija, ekstrudirani polistiren, pasivna kuća, potresna platforma, numeričko modeliranje]]></keywords_hr><keywords_en><![CDATA[geotechnical seismic isolation, extruded polystyrene, passive house, shaking table, numerical modeling]]></keywords_en><summary_hr><![CDATA[Sveukupni cilj ovog projektnog prijedloga je razvoj nove klase geotehničke seizmičke izolacije (GSI) primjenom sloja termoizolacija od ekstrudiranog polistirena (XPS) ispod temelja zgrade koji će, osim osnovne funkcije termoizolacije, služiti i kao seizmička izolacija.Provesti će se opsežna eksperimentalna i numerička istraživanja efikasnosti ove izolacije. Cilj je unaprjeđenje razumijevanja ponašanja zgrada sa seizmičkom izolacija ali i da koncept bude racionalan i jednostavan za realizaciju, te da nađe široku praktičnu primjenu. Predviđeni sustav seizmičke izolacije trebao bi biti posebno efikasan kod krutih i srednje krutih građevina temeljenih na čvrstom i srednje čvrstom tlu. Primjena koncepta je ograničena na niske i srednje visoke zgrade, tj. na slučajeve gdje vertikalna naprezanja ispod temelja ne premašuju dopuštenu nosivost sloja XPS-a. Predviđeni aseizmički sloj od XPS-a prvenstveno je namijenjen za smanjenje horizontalnih potresnih ubrzanja, čiji je utjecaj dominantan kod većine građevina (u odnosu na vertikalno ubrzanje). Očekuje se da takav sloj omogući disipaciju energije potresa  preko svojih horizontalnih posmičnih deformacija i „proklizavanja“, uz prihvatljive horizontalne pomake građevine u odnosu na tlo.U odnosu na koncept seizmičke izolacije pomoću diskretnih složenih naprava i uređaja, predviđeni koncept seizmičke izolacije trebao bi imati slijedeće prednosti:- proširenje tržišta pasivnih kuća - doprinos ispunjenju cilja energetski neutralne Europe do 2050. godine- primjena kod građevina sa složenom tlocrtnom dispozicijom zidova- značajno veća sigurnost građevine od potresnog djelovanja- značajno smanjenje stupnja oštećenja građevina od potresnog djelovanja- nema troškova održavanja- trajnost sustava odgovara životnom vijeku građevine- termoizolacija je istovremeno seizmička izolacija]]></summary_hr><summary_en><![CDATA[The overall objective of this project proposal is to develop a new class of geotechnical seismic isolation (GSI) by applying a thermal insulation layer of extruded polystyrene (XPS) under the foundation of a building, which will, in addition to the basic function of thermal insulation also serves as seismic isolation.Extensive experimental and numerical studies are being carried out on the efficiency of this insulation. The aim is to improve the understanding of the behavior of buildings with seismic isolation, but also to implement the concept rationally and simply and to find a broad practical application. The planned seismic isolation system should be particularly effective for rigid and medium-stiff buildings based on solid and medium-stiff ground. The application of the concept is limited to low and medium-rise buildings, i.e. to cases where the vertical stresses under the foundation do not exceed the allowable bearing capacity of the XPS layer. The proposed aseismic XPS layer is primarily intended to reduce horizontal seismic accelerations, the influence of which is dominant in most buildings (relative to vertical accelerations). Such a layer is expected to allow the dissipation of seismic energy through its horizontal shear deformations and &#39;&#39;slippage&#39;&#39;, with acceptable horizontal displacements of the building relative to the ground.Compared to the concept of seismic isolation using discrete complex devices and equipment, the proposed concept of seismic isolation should have the following advantages:- expansion of the passive house market- contribution to achieving the goal of an energy-neutral Europe by 2050- application in buildings with complex floor plans and wall structures- significantly higher safety of the building against seismic effects- significant reduction in damage to buildings due to seismic effects- no maintenance costs- the durability of the system corresponds to the service life of the building- thermal insulation is also seismic isolation]]></summary_en></project><project>
<id>17711</id><title_hr><![CDATA[Atomske deformacije i pripadne promjene svojstava 2D materijala]]></title_hr><title_en><![CDATA[Atomic deformations and related properties tuning of 2D Materials]]></title_en><user_id>3090</user_id><user_firstLast_name>Iva Šrut Rakić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2025-02</proposal_call><code>UIP-2025-02-1179</code><acronim><![CDATA[ADAPT-2D]]></acronim><duration>19.02.2026 - 18.02.2031</duration><status>U tijeku</status><financ_value>299.962,50 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut za fiziku]]></institution_hr><institution_en><![CDATA[Institute of Physics in Zagreb]]></institution_en><team_members_id>870133, 5765, 19881, </team_members_id><team_members_names><![CDATA[Karmen Kapustić, Ida Delač, Borna Pielić, ]]></team_members_names><keywords_hr><![CDATA[površinska fizika, 2D materijali, Skenirajuća tunelirajuća mikroskopija i spektroskopija, naprezanje, inžinjering elektronske strukture, ]]></keywords_hr><keywords_en><![CDATA[surface physics, 2D materials, Scanning tunneling microscopy, Scanning tunneling spectroscopy, strain, band structure engineering]]></keywords_en><summary_hr><![CDATA[2D materijali su posebno zanimljivi za tehnološku primjenu zbog velike raznolikosti svojstava, slaganja u heterostrukture, male debljine i iznimne mehaničke fleksibilnosti. Ova svojstva omogućuju velike deformacije koje mogu značajno izmijeniti njihove elektroničke, optičke, magnetske, transportne i kemijske karakteristike. Kao rezultat toga, inženjering naprezanja ili &#39;&#39;straintronike&#39;&#39; pokazao se kao učinkovit način podešavanja elektroničkih svojstava 2D materijala.  Međutim, i dalje postoje ključni izazovi, uključujući oslanjanje na prostorno prosječne tehnike koje ne omogućuju uvid u lokalna mehanička i elektronička svojstva materijala, poteškoće u postizanju kristalografski preciznog, dizajniranog i prilagodljivog naprezanja te stabilnost materijala u ambijentalnim uvjetima, koja često ograničava izbor materijala.Ovaj projekt ima za cilj riješiti ove probleme i unaprijediti područje straintronike u 2D materijalima kroz (i) razvoj inovativnog MBE rasta 2D materijala na pred-strukturiranim supstratima kako bi se induciralo kontrolirano naprezanje, (ii) primjenu lokalnih, atomski razlučivih tehnika poput STM-a, STS-a i KPFM-a za izravno istraživanje učinaka naprezanja te (iii) uvođenjem nove metode UHV eksfolijacije (KISS) za stvaranje i istraživanje novih 2D materijala i naprezanjem induciranih faza. Ovi napori omogućit će rješavanje temeljnih znanstvenih pitanja te otvoriti nove mogućnosti za nanoelektroniku, kvantne materijale i fleksibilne optoelektroničke uređaje. Osim toga, projekt će omogućiti formiranje nove istraživačke grupe, unaprijediti naše međunarodno iskustvo i kompetencije te povećati međunarodnu vidljivosti grupe.]]></summary_hr><summary_en><![CDATA[2D materials are particularly interesting for technological application, due to large variety of their properties, ability to stack them in heterostructures, small thickness and incredible mechanical flexibility and robustness. This offers the possibility to subject them to high mechanical deformations, which are able to induce major modifications in the electronic, optical, magnetic, transport, and chemical properties of 2D materials. As a result, strain engineering, or “straintronics”, proved to be an efficient strategy to tune the electronic properties of 2D materials. However, key challenges remain, including relying on spatially averaging techniques which do not provide insight into local mechanical and electronic properties of material, difficulties in achieving crystallographically precise, designable and tunable strain, and ambient material stability which often limits the choice of materials. This project aims to solve these issues and advance the field of straintronics in 2D materials by (i) developing innovative MBE growth of 2D materials on pre-patterned substrates to induce controlled strain, (ii) utilizing local, atomically resolved techniques such as STM, STS, and KPFM to directly probe strain effects, and (iii) applying a novel UHV exfoliation method (KISS) to create and explore new 2D materials and strain-induced phases. These efforts will address fundamental scientific questions while enabling new possibilities for nanoelectronics, quantum materials, and flexible optoelectronic devices. Additionally, project will facilitate formation of a new research group, advance our international experience and competence and allow us to increase our international recognition. ]]></summary_en></project><project>
<id>17714</id><title_hr><![CDATA[Niskotemperaturna eutektička otapala i njihova primjenjivost u stabilizaciji i isporuci proteina]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3228</user_id><user_firstLast_name>Ivana Radojčić Redovniković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-3717</code><acronim><![CDATA[DESsolvProt]]></acronim><duration>12.11.2025 - 12.11.2031</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Biotehnologija, </scie_field_hr><scie_field_en>Biotechnology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Food Technology and Biotechnology]]></institution_en><team_members_id>872921</team_members_id><team_members_names><![CDATA[ Doktorand: Martina Železnjak ]]></team_members_names><keywords_hr><![CDATA[niskotemperaturna eutektička otapala, proteini, stabilnost, isporuka, eutektogelovi, lizozim, inzulin]]></keywords_hr><keywords_en><![CDATA[deep eutectic solvents, proteins, stability, delivery, eutectogels, lysozyme, insulin]]></keywords_en><summary_hr><![CDATA[Proteini imaju ključnu ulogu u različitim industrijskim granama, poput prehrambene, biotehnološke i kozmetičke, čineći osnovu za razne proizvode te u razvoju terapija i lijekova. Međutim, izazovi poput nestabilnosti proteina tijekom skladištenja i isporuke, potiču akademsku i industrijsku zajednicu  na razvoj novih stabilnih proteinskih formulacija za sigurnu i kontroliranu dostavu lijeka.Niskotemperaturna eutektička otapala (Deep Eutectic Solvents, DES) su netoksična, biorazgradiva i visoko prilagodljiva otapala koja učinkovito stabiliziraju biomolekule poput proteina. Ova otapala također pokazuju antioksidativna i antimikrobna svojstva, što ih čini privlačnima za primjenu u farmaceutskoj industriji. Stoga je farmaceutska industrija izrazito zainteresirana za DES-ove kao osnove za stvaranje novih proizvoda, s obzirom na njihovu svestranu ulogu i slaganje sa strogim regulatornim standardima.Na temelju navedenog, glavni cilj projekta je dizajn stabilnih tekućih formulacija na bazi DES-ova odnosno eutektogelova za stabilizaciju proteina. Istraživanje podrazumijeva dvije ključne faze: (i) dizajniranje biokompatibilnih DES-ova i eutektogelova za očuvanje funkcionalnost proteina kroz probir različitih DES-ova primjenom eksperimentalnih i računalnih metoda te (ii) razvoj stabilnih tekućih formulacija na bazi DES-ova odnosno eutektogelova za isporuku proteina, osiguravajući njihovu visoku bioraspoloživost i biološku aktivnost. Stečena saznanja o primjenjivosti DES-ova i eutektogelova u stabilizaciji i isporuci proteina predstavljat će značajan iskorak prema industrijskoj implementaciji ovih otapala, ne samo u farmaceutskoj industriji već i u drugim industrijskim granama koji se oslanjaju na tehnologije temeljene na proteinima.]]></summary_hr><summary_en><![CDATA[Proteins play a crucial role in industries such as food, biotechnology, and cosmetics, forming the basis for products and advancements in therapy and drug development. However, challenges like protein instability during storage and administration persist, prompting research efforts to develop stable protein formulations for safe and controlled drug delivery.Deep Eutectic Solvents (DES) are non-toxic, biodegradable, and highly customizable solvents that effectively stabilize biomolecules such as proteins. These solvents also demonstrate antioxidant and antimicrobial properties, making them appealing for drug delivery applications. Therefore, the pharmaceutical industry is enthusiastic about utilizing DES to create new products, given their versatility and capacity to meet stringent regulatory standards.Based on the aforementioned points, the main objective of the project is to design stable liquid formulations based on DES and eutectogels for protein stabilization. This involves two key research phases: (i) designing biocompatible DES and eutectogels that preserve protein functionality through screening various DES candidates using experimental and computational methods, and (ii) developing stable DES-based liquid or eutectogel formulations for protein delivery, ensuring high bioavailability and biological activity of the proteins.The knowledge gained about the applicability of DES and eutectic gels in protein stabilization and delivery will represent a significant step forward towards the industrial implementation of these solvents, not only in the pharmaceutical industry but also in other sectors relying on protein-based technologies.]]></summary_en></project><project>
<id>17715</id><title_hr><![CDATA[Povećanje učinkovitosti nazalne primjene lijekova u djece i adolescenata: interdisciplinarni pristup]]></title_hr><title_en><![CDATA[Boosting nasal drug delivery efficiency in children and adolescents: an interdisciplinary approach]]></title_en><user_id>5296</user_id><user_firstLast_name>Anita Hafner</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-3811</code><acronim><![CDATA[Boost4CA]]></acronim><duration>05.12.2025 - 04.12.2028</duration><status>U tijeku</status><financ_value>194.000,00 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Farmacija, </scie_field_hr><scie_field_en>Pharmaceutical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Farmaceutsko-biokemijski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Pharmacy and Biochemistry]]></institution_en><team_members_id>24926, 858334, 6672, 4075, 3915, 12487, 855425, 905, 4284, 865612, 26775, 867978, 22585, 853, 25388, 865519, 221, 4532, 873272, </team_members_id><team_members_names><![CDATA[Laura Nižić Nodilo, Mirna Perkušić, Ivan Pepić, Jasmina Lovrić, Mario Jug, Maja Šegvic Klarić, Cvijeta Jakobušić Brala, Daniela Amidžić Klarić, Dijana Zadravec, Mia Smoljan Basuga, Maša Safundžić Kučuk, Sabino Sepčić, Ivo Ugrina, Drago Špoljarić, Robert Keser, Ana Catarina Silva, Vedran Micek, Marko Velimir Grgić, Matea Prenc, ]]></team_members_names><keywords_hr><![CDATA[Nazalna primjena lijekova, Nanostrukturirani lipidni nosači, Mikrosfere, Nazalna depozicija, Djeca, Adolescenti, Neuroupala, Kronični rinosinuitis]]></keywords_hr><keywords_en><![CDATA[Nasal drug delivery, Nanostructured lipid carriers, Microspheres, Nasal deposition, Children, Adolescents, Neuroinflammation, Chronic rhinosinusitis]]></keywords_en><summary_hr><![CDATA[Nazalna sluznica, kao mjesto primjene lijeka, pruža posebne prednosti u liječenju djece i adolescenata (CA). Omogućuje lokalnu, sistemsku i izravnu dostavu lijeka u mozak, bezbolno cijepljenje i izbjegavanje poteškoća s gutanjem. Niz lijekova odobreno je za nazalnu primjenu u CA populaciji. Međutim, proširenje terapijskih opcija za tu primjenu zahtijeva razvoj inovativnih farmaceutskih oblika prilagođenih CA pacijentima uz učinkovitiju depoziciju u ciljnim regijama nosne šupljine.Nedavno je naš istraživački tim razvio ideju povezivanja formulacijskih parametara i parametara primjene pristupom kakvoće utemeljene kroz dizajn s ciljem optimiranja profila nazalne depozicije in vitro prema specifičnom oboljenju, što se pokazalo obećavajućim. Nadalje, profil nazalne depozicije povezan je i s anatomskim mjerama nosne šupljine, koje se značajno mijenjaju odrastanjem. Dosad je provedeno vrlo malo istraživanja u tom segmentu. U sklopu predloženog projektaBoost4CA razvit će se platforma za nazalnu primjenu lijeka prilagođenu CA pacijentima. Upotrijebit će se pametni dizajn naprednih formulacija i parametri primjene specifični za dob. Projektni ciljevi usmjereni su na razvoj mikrosfera kontrolirane veličine te formulacija nanostrukturiranih lipidnih nosača za nazalnu primjenu u CA pacijenata, s potencijalom poboljšane dostave kortikosteroida izravno u mozak kod neuroupale, odnosno povećane antimikrobne aktivnosti antibiotika kodkroničnog rinosinuitisa. Regresijski modeli za individualizaciju nazalne primjene prema dobi i oboljenju uspostavit će se temeljem in silico modeliranja nazalne depozicije i validirati na 3D-printanim modelima nosne šupljine CA pacijenata (3-17 godina). In vivo potvrda koncepta biofarmaceutskog potencijala formulacija provest će se ispitivanjima u štakora. Ostvareni rezultati predstavljat će jedinstveni doprinos istraživanju nazalne terapije za CA pacijente te potencirati razvoj inovativnihoblika drugih lijekova za nazalnu primjenu u CA pacijenata.]]></summary_hr><summary_en><![CDATA[Nasal drug delivery offers distinct advantages in children and adolescents (CA) therapy. It presents a pathway for local and systemic drug delivery, brain targeting and mucosal vaccination without causing pain and avoiding medication swallowing difficulties. Nasal delivery in CA patients is approved for a range of drugs. However, widening nasal therapeutic options requires functional and CA-adjusted new pharmaceutical forms and efficient drug deposition in nasal regions of interest. Recently, our research team has pioneered the idea of coupling formulation and administration parameters by a Quality-by-Design approach to optimise nasal deposition in vitro in relation to the specific disease, holding great promise in targeted nasal drug delivery. Furthermore, nasal deposition is also related to anatomical parameters of the nasal cavity, which remarkably change with growing up. So far, very little research has been done to address this issue. Boost4CA will set up CA-tailored nasal delivery based on the smart design of advanced drug formulations, coupled with age-specific administration parameters. Project objectives focus on the development of size-controlled microspheres and nanostructure lipid carrier-based drug formulations as CA nasal delivery platforms with the potential to enhance nose-to-brain delivery of corticosteroid in neuroinflammation and improve antimicrobial activity of an antibiotic in chronic rhinosinusitis. Regression models forindividualisation of nasal delivery patterns concerning age and specific disease will be derived based on in silico modelling of nasal deposition and validated in 3D-printed nasal casts of CA patients (3-17 years). In vivo proof-of-concept of formulations&#39; biopharmaceutical potential will be attained by studies in rats. Boost4CA will uniquely contribute to the field of CA nasal therapy investigation and potentiate the development of advanced delivery systems for other medicines to be appliednasally in CA patients.]]></summary_en></project><project>
<id>17718</id><title_hr><![CDATA[Coffee ring&#39; efekt &#39;Lab on a Chip&#39; okruženja u razvoju novih formulacija lijekova]]></title_hr><title_en><![CDATA[]]></title_en><user_id>26087</user_id><user_firstLast_name>Ernest Meštrovic</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-6259</code><acronim><![CDATA[CORE4PHARM]]></acronim><duration>10.11.2025 - 09.11.2031</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet kemijskog inženjerstva i tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Chemical Engineering and Technology]]></institution_en><team_members_id>872901</team_members_id><team_members_names><![CDATA[ Doktorand: Donna Danijela Dragun ]]></team_members_names><keywords_hr><![CDATA[formulacije, lijekovi, coffee ring efekt, samoorganizirajući sustavi, Inkjet tehnologija, mikrokapljice, Ramanova spektroskopija]]></keywords_hr><keywords_en><![CDATA[formulations, drugs, coffee ring effect, self-organizing systems, inkjet technology, microdroplets, Raman spectroscopy]]></keywords_en><summary_hr><![CDATA[Samoorganizirajući sustavi predstavljaju ključ za razumijevanje kompleksnih sustava s jedne strane a s druge daju mogućnost istraživanja niza  interakcija. U ovom projektu cilj je iskoristiti pojavu &#39;&#39;coffee ring&#39;&#39; efekta za razvoj novih protokola za evaluaciju kandidata za lijekove u ranim fazama otkrića, poboljšavajući učinkovitost i ekonomičnost u istraživanju i razvoju lijekova. Istraživanje je fokusirano na samoorganizirajuće motive, posebno koristeći tehnologiju temeljenu na inkjet printerima za precizno nanošenje uzorak u obliku mikrokapljica. Koristeći specijalizirane uređaje, tradicionalan ručni način pripreme uzoraka koje obično uključuje stotine pokusa po formulaciji može se proširiti na tisuće. Ova ekspanzija omogućava provođenje opsežnih eksperimenata s minimalnom količinom materijala, što je ključno u ranim fazama istraživanja gdje je dostupnost materijala vrlo ograničena.  Predloženi tehnološki i znanstveni  napreci uključuju sistematsku analizu podataka, što je središnji dio projekta. Upotreba različitih tehnika mikroskopije, kao što su optička mikroskopija i mikroskopija elektronskim skeniranjem (SEM), igra ključnu ulogu u ovoj fazi, pružajući uvide u strukturna i morfološka svojstva uzoraka. Ramanova spektroskopija nudi kemijsku karakterizaciju na mikroskopskoj razini, ključnu za razumijevanje svojstava i određivanje interakcija što je ključ u osmišljavanju formulacija.  Dalje, projekt istražuje integraciju strojnog učenja s mikroskopskom analizom kako bi se poboljšalo predviđanje farmaceutskih svojstava i performansi. Napredni algoritmi mogu analizirati slike kako bi detektirali uzorke i značajke koje klasične metode ne mogu odrediti što omogućuje dublje razumijevanje kako fizikalna i kemijska svojstva utječu na ponašanje i stabilnost lijekova. Cilj je razviti platformu koja će omogućiti da se ovim postupkom steknu spoznaje na nekoliko miligrama djelatne tvari za što bi u klasičnom pristupom zahtijevalo nekoliko desetina grama materijala.]]></summary_hr><summary_en><![CDATA[Self-organizing systems are key to understanding complex systems and exploring interactions. This project aims to utilize the &#39;&#39;coffee ring&#39;&#39; effect to develop new protocols for evaluating drug candidates in early discovery stages, enhancing research efficiency and cost-effectiveness. The focus is on self-organizing motifs, using inkjet printer technology for precise application of microdroplets. Specialized devices allow the expansion of traditional manual sample preparation from hundreds to thousands of trials per formulation. This enables extensive experiments with minimal material, crucial in phases where material availability is limited. Technological and scientific advances proposed include systematic data analysis, central to the project. Techniques like optical microscopy and scanning electron microscopy (SEM) provide insights into structural and morphological properties. Raman spectroscopy offers chemical characterization at the microscopic level, essential for understanding properties and determining interactions critical in formulation design.Additionally, the project integrates machine learning with microscopic analysis to enhance prediction of pharmaceutical properties and performance. Advanced algorithms can analyze images to detect patterns and features that traditional methods miss, allowing deeper understanding of how physical and chemical properties affect drug behavior and stability.The goal is to develop a platform that enables gaining insights from just a few milligrams of active substance, a quantity that would traditionally require several tens of grams of material. This approach not only streamlines research but also significantly reduces material requirements, fostering more sustainable and innovative pharmaceutical development]]></summary_en></project><project>
<id>17719</id><title_hr><![CDATA[Mitofagija u homeostazi placentogeneze: Uloga selektivne autofagije mitohondrija u diferencijaciji trofoblasta i placentalnim insuficijencijama ]]></title_hr><title_en><![CDATA[Mitophagy in Placental Homeostasis: The Role of Selective Mitochondrial Autophagy in Trophoblast Differentiation and Placental Insufficiencies ]]></title_en><user_id>17855</user_id><user_firstLast_name>Mija Marinković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2025-02</proposal_call><code>UIP-2025-02-8501</code><acronim><![CDATA[MitoPlace_HOME]]></acronim><duration>01.04.2026 - 31.03.2031</duration><status>U tijeku</status><financ_value>300.000,00 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Science]]></institution_en><team_members_id>865165, 855419, 870292, 869830, 870313, 870617, </team_members_id><team_members_names><![CDATA[Ana Rožić, Mia Dželalija, Ivana Popović, Tina Domjanović, Petar Đolonga, Stipe Dumančić, ]]></team_members_names><keywords_hr><![CDATA[Mitofagija, placenta, preeklampsija, diferencijacija trofoblasta, mitohondrijska dinamika]]></keywords_hr><keywords_en><![CDATA[Mitophagy, placenta, preeclampsia, trophoblast differentiation, mitochondrial dynamics]]></keywords_en><summary_hr><![CDATA[Placenta - vrhunac morfološkog i funkcionalnog savršenstva, usklađuje složene biološke zahtjeve nužne za zdravu trudnoću. Unatoč istraživanjima, mnogi poremećaji trudnoće i dalje imaju nejasnu etiologiju. Poremećen prijenos hranjivih tvari i kisika kroz placentu u većini takvih poremećaja ukazuje na ključnu ulogu mitohondrija trofoblasta, metaboličke srži posteljice, naglašavajući da bi funkcija mitohondrija trofoblasta mogla biti ključna za razumijevanje ovih problema.Dosadašnje teorije o patofiziološkim mehanizmima placentalnih insuficijencija fokusiraju se na narušenu oksidativnu fosforilaciju i posljedična mitohondrijska oštećenja, što ističe važnost kontrole kvalitete mitohondrija u homeostazi placente. Ipak, karakteristike mitohondrija u placentama s preeklampsijom, najčešćom insuficijencijom, upućuju na postojanje alternativnog mitohondrijskog mehanizma koji regulira diferencijaciju trofoblasta, ključnog procesa razvoja placente.Projekt se fokusira na istraživanje selektivne autofagije mitohondija - mitofagije kao novog mehanizma kontrole kvalitete mitohondrija u diferencijaciji trofoblasta. Korištenjem robusnih metodologija za transkriptomsko i proteomsko profiliranje različitih populacija placentalnih stanica, cilj je pružiti detaljna saznanja o mehanizmima mitofagije tijekom placentogeneze zdravih i preeklamptičkih placenti. Ovakvim integriranim pristupom, istraživanja na ljudskim uzorcima, mišjim modelima i trofoblastnim linijama, unaprijedit će se razumijevanje uloge mitofagije u placentogenezi i patofiziologiji placentalnih insuficijencija.  Autofagija sve više postaje predmet intenzivnog istraživanja zbog svoje uloge u patogenezi brojnih bolesti. U tom kontekstu, krije se i mogućnost da se modifikacija autofagije koristi kao terapijska strategija. Stoga, istraživanje molekularnih mehanizama mitofagije može otvoriti put prema novim terapijskim pristupima za liječenje placentalnih insuficijencija, za koje trenutno ne postoji učinkovita terapija.]]></summary_hr><summary_en><![CDATA[The placenta – a pinnacle of morphological and functional perfection – coordinates complex biological demands necessary for a healthy pregnancy. Despite research, many pregnancy disorders still have an unclear etiology. Impaired transfer of nutrients and oxygen across the placenta highlights the crucial role of mitochondrial function in trophoblasts, the metabolic core of the placenta, suggesting mitochondrial function in trophoblasts may be key to understand these issues.Current theories on the pathophysiological mechanisms of placental insufficiencies focus on impaired oxidative phosphorylation and consequent mitochondrial damage, emphasizing the importance of mitochondrial quality control in placental homeostasis. However, mitochondrial characteristics in preeclamptic placentas, the most common insufficiency, point to the existence of an alternative mitochondrial mechanism that regulates trophoblast differentiation, a key process in placental development.This project focuses on investigating selective mitochondrial autophagy – mitophagy – as a novel mechanism of mitochondrial quality control in trophoblast differentiation. Using robust methodologies for transcriptomic and proteomic profiling of placental cells, the goal is to provide insights into the mechanisms of mitophagy during placentogenesis in both healthy and preeclamptic placentas. This integrated approach, combining human sample, mouse models, and trophoblast cell lines, will enhance our understanding of the role of mitophagy in placentogenesis and the pathophysiology of placental insufficiencies.Autophagy has become the subject of intensive research due to its role in the pathogenesis of numerous diseases. In this context, there is also the potential to modify autophagy as a therapeutic strategy. Therefore, investigating the molecular mechanisms of mitophagy may pave the way for new therapeutic approaches for treating placental insufficiencies, for which there is currently no effective therapy.]]></summary_en></project><project>
<id>17720</id><title_hr><![CDATA[Fluidni i kvazi-fluidni međuprodukti u reakcijama u čvrstom stanju]]></title_hr><title_en><![CDATA[]]></title_en><user_id>329</user_id><user_firstLast_name>Nikola Biliškov</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-1155</code><acronim><![CDATA[GrindCore-2]]></acronim><duration>21.01.2026 - 29.09.2029</duration><status>U tijeku</status><financ_value>44,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>25267</team_members_id><team_members_names><![CDATA[ Doktorand: Toni Grgurić ]]></team_members_names><keywords_hr><![CDATA[čvrsto stanje, mehanokemija, međupovršine, eutektici, difuzija, spektroskopija, PXRD]]></keywords_hr><keywords_en><![CDATA[solid state, mechanochemistry, interfaces, eutectics, diffusion, spectroscopy, PXRD]]></keywords_en><summary_hr><![CDATA[Uzimajući u obzir temeljnu činjenicu da bilo koja kemijska reakcija iziskuje mobilnost molekula reaktanata kako bi se omogućili njihovi sudari, čini se da redovno opažene amorfne faze, koje nastaju u prvim fazama reakcija, igraju aktivnu ulogu. Te fluidne ili kvazi-fluidne faze djeluju kao medij što omogućuje mobilnost uključenih kemijskih vrsta, osiguravajući okruženje u kojem je kemijska reakcija moguća. S druge strane, jasno je da su u čvrstom stanju kemijske reakcije inicirane dodirom dviju tvari te se odvijaju na njihovoj dodirnoj površini. Ipak, taj fundamentalni aspekt do sada nije bio dovoljno detaljno obrađen. Prodor u mehanističke detalje tih procesa će u okviru ovog projekta biti omogućen izučavanjem makroskopski statičnih reakcija s dobro definiranim dodirnim površinama među reaktantima, te njihovim prostorno i vremenski razlučivim kemijskim mapiranjem. S druge strane, vremenski razlučivim praćenjem odabranih makroskopski dinamičkih reakcija u čvrstom stanju, dakle mehanokemijskih reakcija, dobit ćemo rezultate koji će omogućiti komparaciju kinetičkih i ostalih parametara koji određuju reaktivnost s onima dobivenima mapiranjem statičkih reakcija. To će biti omogućeno ekstenzivnim korištenjem korištenjem metoda difrakcije sinhrotronskog X-zračenja na prahu i mikrospektroskopijama. Smatramo da tim pristupom možemo kvalitativno i kvantitativno detektirati i karakterizirati evoluciju kemijskih vrsta uključenih u te fundamentalne procese. Na temelju tih spoznaja, obradit ćemo nekoliko važnih skupina reakcija u čvrstom stanju, koje postaju sve prisutnije u suvremenoj preparativnoj kemiji. Konkretno, obradit ćemo reakcije ubrzanog starenja, kokristalizacije iz molekulskih eutektičkih smjesa i tekućinama potpomognuto mljevenje. Na kraju ćemo sve to primijeniti na reakcije u čvrstom stanju, koje su relevantne za tehnološke, biomineralizacijske i geološke procese. Očekujemo da ćemo time dati doprinos temeljnom razumijevanju reaktivnosti u čvrstom stanju.]]></summary_hr><summary_en><![CDATA[Fundamental fact that any chemical reaction requires mobility of reactant molecules to allow their collisions, it seems that regularly observed amorphous phases play an active role at the first stages of solid-state reactions. These fluid or quasi-fluid intermediates act as a medium that enables mobility of involved chemical species, providing an environment in which a chemical reaction is possible. On the other hand, it is clear that solid-state chemical reactions are initiated by the contact of two substances and take place on the interface. However, this fundamental aspect has not been dealt with in sufficient detail so far. Within the framework of this project, penetration into the mechanistic details of these processes will be enabled by studying macroscopically static reactions on well-defined interfaces, and by their spatially and temporally resolved chemical mapping. On the other hand, time-resolved monitoring of selected macroscopically dynamic solid-state reactions, i.e. mechanochemical reactions, we will obtain results that will enable comparison of kinetic and other parameters that determine reactivity with those obtained by mapping static reactions. This will be made possible by extensive use of synchrotron X-ray powder diffraction and microspectroscopies. By this approach we will be able to qualitatively and quantitatively detect and characterize the evolution of chemical species involved in these fundamental processes. Based on these findings, we will discuss several important groups of reactions in the solid state, which are becoming more and more prevalent in modern preparative chemistry. In particular, we will investigate accelerated aging reactions, cocrystallizations from molecular eutectic mixtures and liquid-assisted grinding. Finally, we will apply all this to solid-state reactions relevant to technological, biomineralization and geological processes. ]]></summary_en></project><project>
<id>17730</id><title_hr><![CDATA[Remisija dijabetesa tipa 2 pomoću mediteranske prehrane, tjelesne aktivnosti i psihološke potpore: randomizirana klinička studija]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1358</user_id><user_firstLast_name>Ivana Kolčić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-1599</code><acronim><![CDATA[REMeDI2ME]]></acronim><duration>01.12.2025 - 01.12.2031</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Javno zdravstvo i zdravstvena zaštita, </scie_field_hr><scie_field_en>Public health and health services, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Split School of Medicine]]></institution_en><team_members_id>872961</team_members_id><team_members_names><![CDATA[ Doktorand: Ivana Grgić ]]></team_members_names><keywords_hr><![CDATA[dijabetes tip 2, remisija, pretilost, mediteranska prehrana, tjelesna aktivnost, stres, zdrav način života, mršavljenje, biomarkeri]]></keywords_hr><keywords_en><![CDATA[type 2 diabetes, remission, obesity, Mediterranean diet, physical activity, stress, healthy lifestyle, weight loss, biomarkers]]></keywords_en><summary_hr><![CDATA[Dijabetes tipa 2 (DM2) i pretilost vodeći su uzroci morbiditeta i mortaliteta, kao i velikog financijskog tereta društva. Glavni cilj ovog eksperimentalnog istraživanja je postizanje remisije DM2, korištenjem intenzivne promjene životnog stila: mediteranske prehrane, tjelesne aktivnosti i psihosocijalne potpore. U ovom multidisciplinarnom projektu, kojeg će provoditi znanstvenici 5 znanstvenih područja, sudjelovat će 120 ispitanika s dijagnozom DM2 postavljenom unutar 6 godina, s indeksom tjelesne mase 27-45 kg/m2, bez terapije inzulinom i težih komplikacija. Nasumičnim odabirom ispitanici će se podijeliti u eksperimentalnu i kontrolnu skupinu. Eksperimentalna skupina će se hraniti prema principima mediteranske prehrane s blagim kalorijskim deficitom, pod nadzorom nutricioniste, provoditi svakodnevnu tjelesnu aktivnost pod nadzorom kineziologa te ojačati otpornost na stres uz potporu psihologa i grupnog rada, sve uz kontrolu liječnika specijalista i depreskripciju lijekova prema potrebi. Intervencija uključuje tjedno individualno i grupno savjetovanje i radionice kroz 6 mjeseci, nakon čega će se ispitanici pratiti još 1,5 g. Kontrolna skupina će se pratiti 2 godine, uz savjetovanje o ulozi zdravih životnih navika i uobičajenu kliničku skrb. Glavni ishodi istraživanja su remisija DM2 (HbA1c<6,5%) i gubitak mase od >15 kg, s dodatnim ishodima poboljšanja niza kliničkih parametara i biomarkera: inzulinske rezistencije, upale niskog stupnja, oksidativnog stresa, glikana, endokrinih disruptora i obesogena, uz praćenje nuspojava (sekundarni ishod), što će osigurati preduvjete za unapređenje personalizirane brige za zdravlje osoba s DM2. Ovaj projekt ima visoki potencijal za ostvarivanje translacije spoznaja, s višestrukim pozitivnim učincima na zdravstvenu skrb, kao i za postizanje iznimnog znanstvenog doprinosa. Kao posljedica svega navedenog, uspješno proveden projekt ove tematike može rezultirati dalekosežnim pozitivnim društvenim i gospodarskim učincima.]]></summary_hr><summary_en><![CDATA[Type 2 diabetes (DM2) and obesity are leading causes of morbidity and mortality, with a large financial burden on society. The main goal of this experimental study is to achieve DM2 remission, using intensive lifestyle intervention: Mediterranean diet, physical activity and psychosocial support. In this multidisciplinary project, carried out by scientists from 5 scientific fields, 120 subjects will be included, diagnosed with DM2 within 6 years, a body mass index of 27-45 kg/m2, without insulin therapy or severe complications. Subjects will be randomly allocated to experimental or control group. Experimental group will eat Mediterranean diet with a mild caloric deficit, under the supervision of a nutritionist, perform daily physical activity under the supervision of a kinesiologist, and strengthen resilience to stress with the support of a psychologist and group work, all under the supervision of physicians, and deprescription of medications as needed. The intervention includes weekly individual and group counseling and workshops for 6 months, with 1.5 years of follow-up. The control group will be followed for 2 years, and advised on the role of healthy lifestyle, while having the usual clinical care. The main outcomes of the study are DM2 remission (HbA1c<6.5%) and weight loss of >15 kg, with additional outcomes of improvement in clinical parameters, and a number of biomarkers: insulin resistance, low-grade inflammation, oxidative stress, glycans, endocrine disruptors and obesogens, while monitoring for side effects (secondary outcome). All of this will provide the prerequisites for the improvement of the personalized medical care for people with DM2. This project has a high potential for knowledge translation, with multiple positive effects on the provision of health care, as well as achieving exceptional scientific contribution. As a consequence, successfully implemented project on this topic can result in far-reaching positive social and economic effects.]]></summary_en></project><project>
<id>17731</id><title_hr><![CDATA[Lokalizacija i funkcija akvaporina 3 i akvaporina 5 u stanicama raka: utjecaj na otpornost i odgovor na terapiju]]></title_hr><title_en><![CDATA[Localization and Function of Aquaporin 3 and Aquaporin 5 in Cancer Cells: Effects on Treatment Resistance and Response]]></title_en><user_id>5615</user_id><user_firstLast_name>Ana Čipak Gašparović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-8980</code><acronim><![CDATA[AQPLOCR]]></acronim><duration>05.12.2025 - 04.12.2028</duration><status>U tijeku</status><financ_value>199.955,00 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>12664, 25007, 865065, 866742, 11317, 870612, 26562, 870830, 870658, 23594, 25919, 870230, </team_members_id><team_members_names><![CDATA[Lidija Milković, Marko Tomljanović, Monika Mlinarić, Ivan Lučić, Renata Novak Kujundžić, Hrvoje Silovski, Tajana Silovski, Sandra Tipurić, Katarina Tomulić Brusich, Sanda Bubanović, Graça Soveral, Iva Durut Čupev, ]]></team_members_names><keywords_hr><![CDATA[Akvaporin, AQP3, AQP5, NRF2, adenokarcinom,  tumor dojke, tumor kolona, tumor jetre, tumorska terapija, glukoza ]]></keywords_hr><keywords_en><![CDATA[Aquaporin, AQP3, AQP5, NRF2, adenocarcinoma, breast cancer, colon cancer, liver cancer, cancer therapy, glucose]]></keywords_en><summary_hr><![CDATA[Akvaporini su početno otkriveni i definirani kao membranske pore koje reguliraju prolaz vode kroz membranu. Danas znamo da njihova funkcija iz regulaciju homeostazu vode, reguliraju i migraciju, proliferaciju i adheziju stanica, čime su neizbježno vezani uz tumore. Uz regulaciju prolaza vode, akvaporini reguliraju i prolaz drugih malih nenabijenih molekula kao što su: H2O2, urea, NO i CO2, čijom regulacijom pridonose modulaciji staničnih signalnih puteva. U prošlom projektu otvorio je nove smjerove istraživanja o ulozi AQP u tumorima: iznenađujuće, AQP3 i AQP5 se lociraju u jezgrama tumorskih stanica, AQP3 može modulirati PI3K/Akt signalni put se povećava s aktivacijom NRF2, ekspresija AQP i NRF2 ovisi o koncentraciji glukoze. Stoga su ciljevi ovog projekta odrediti je li pojava akvaporina u jezgri univerzalan za tumore, te odrediti dolazi li do njegove interakcije s transkripcijskim faktorima. kako glukoza regulira transkripciju akvaporina, koji su signalni putevi uključeni u regulaciju i kako glukoza utječe na odgovor na terapiju. Budući smo na kliničkim uzorcima pokazali kako se akvaporini povećavaju u tkivu tumora i strome nakon imuno- i kemoterapije, cilj je ispitati promjene akvaporina i povezanih signalnih puteva nakon jedne i više doza terapeutika. Konačno, naše ćemo in vitro rezultate validirati na kliničkim uzorcima. Projekt se fokusira na indentifikaciju zajedničkih obrazaca promjena AQP-a u tumorima, čime bi se akvaporini mogli uspostaviti kao potencijalni biomarkeri za odabir terapije, nudeći novu perspektivnu u personaliziranoj strategiji liječenja raka.]]></summary_hr><summary_en><![CDATA[Initially, aquaporins (AQPs) were identified as membrane channels facilitating water transport. However, their role extends beyond water homeostasis, influencing cell migration, proliferation, and adhesion—processes closely linked to tumor development and progression. These functions are not dependent only on water flow but also on the transport of small, uncharged molecules such as glycerol, H2O2, urea, NO, and CO2. Particularly, the controlled passage of glycerol and H2O2 can modulate key signaling pathways, altering cellular metabolic and signaling processes. Our previous research revealed new insights into AQPs in cancer. Unexpectedly, AQP3 and AQP5 were detected in the nuclei of cancer cells. AQP3 was also shown to regulate the PI3K/Akt signaling pathway, its expression was increased by an NRF2 activator, and both AQP3 and NRF2 expression were influenced by glucose levels. Based on these findings, we aim to determine whether nuclear localization of AQPs is a tumor-specific feature and whether they can interact with transcription factors. Additionally, we will investigate how glucose regulates aquaporin transcription, define the signaling pathways involved, and assess its impact on therapy response. Furthermore, our clinical data show that AQP3 and AQP5 expression increases in both cancer and stromal cells following immuno- and chemotherapy. Thus, we will examine how aquaporin expression and related signaling pathways change after single and multiple doses of therapeutic agents. Finally, we will validate our in vitro findings in clinical samples. By identifying a common pattern of AQP regulation in cancer, this project aims to establish AQPs as potential biomarkers for therapy selection, offering new perspectives for personalized treatment strategies.]]></summary_en></project><project>
<id>17732</id><title_hr><![CDATA[Prenatalna izloženost metal(oid)ima, ftalatima i mikroplastici: učinci na steroidne hormone, ekspresiju microRNA i zdravlje novorođenčeta]]></title_hr><title_en><![CDATA[Prenatal exposure to metal(loid)s, phthalates and microplastics: effects on steroid hormones, microRNA expression and birth outcomes ]]></title_en><user_id>215</user_id><user_firstLast_name>Ankica Sekovanić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-4002</code><acronim><![CDATA[FetalExpo]]></acronim><duration>01.12.2025 - 30.11.2028</duration><status>U tijeku</status><financ_value>199.700,00 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Javno zdravstvo i zdravstvena zaštita, Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Public health and health services, Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Institut za medicinska istraživanja i medicinu rada]]></institution_hr><institution_en><![CDATA[Institute for Medical Research and Occupational Health]]></institution_en><team_members_id>6004, 868395, 867917, 198, 3934, 830, 4156, 12504, 21444, 23188, 4799, </team_members_id><team_members_names><![CDATA[Krunoslav Kuna, Blaženka Sumpor, Banana Kunina, Zorana Kljaković-Gašpić, Daria Pašalić, Maja Lazarus, Nataša Brajenović, Antonija Sulimanec, Andreja Jurič, Ivan Dolanc, Jelena Kovačić, ]]></team_members_names><keywords_hr><![CDATA[metal(oid)i, ftalati, mikroplastika, miRNA, hormoni]]></keywords_hr><keywords_en><![CDATA[metal(oid)s, phthalates, microplastics, miRNA, hormones]]></keywords_en><summary_hr><![CDATA[Ljudi su tijekom svakodnevnog života izloženi štetnim spojevima iz okoliša. Izloženost štetnim spojevima tijekom prenatalnog i postnatalnog razvoja može utjecati na tijek trudnoće, razvoj fetusa i razvoj bolesti kasnije u životu. Istraživanja pokazuju pojavu raznih poremećaja kao rezultat nepravilne prehrane majke, izloženosti sintetičkim hormonima i/ili svakodnevne izloženost štetnim spojevima iz okoliša. U okviru ovog projekta, utjecaj svakodnevne izloženosti istražit će se u skupini zdravih rodilja, parova majka-novorođenče (N=160-200), prikupljenih u rodilištu Kliničkog bolničkog centra &#39;&#39;Sestre milosrdnice&#39;&#39; u Zagrebu. Uz nove/dodatne informacije o dnevnoj izloženosti majke i fetusa metal(oid)ima, po prvi puta u Hrvatskoj odredit će se razine metabolita ftalata i procijeniti izloženost majke i fetusa tim štetnim spojevima. Ispitat će se prisutnost i karakterizirati vrsta mikroplastike u posteljici te procijeniti njezin potencijalni štetni učinak na funkciju posteljice i zdravlje djeteta in utero. Također će se istražiti učinci izloženosti sveprisutnim štetnim spojevima iz okoliša, odnosno metal(oid)ima, ftalatima i mikroplastici, na sintezu steroidnih hormona važnih za normalan tijek i ishod trudnoće. Postnatalne opasanosti za zdravlje povezane s promjenama u razvojnom programiranju uslijed izloženosti metal(oid)ima, ftalatima i mikroplastici procijenit će se određivanjem ekspresije miRNA, malih nekodirajućih molekula koje reguliraju ekspresiju gena.]]></summary_hr><summary_en><![CDATA[In daily life, individuals are exposed to a wide range of environmental toxicants, and exposure to environmental pollutants during prenatal and postnatal periods can affect pregnancy progress and fetal development, and increase risk of developing diseases later in life.  Studies show the appearance of various disorders as a result of improper maternal nutrition, exposure to synthetic hormones, and daily exposure to harmful environmental toxicants. Within this project, the impact of daily exposure will be investigated in a group of healthy postpartum women, mother-newborn pairs (N=160-200) recruited in the maternity of the University Hospital ”Sisters of Charity”, Zagreb. For the first time in Croatia, the levels of phthalate metabolites will be determined, and the mother and fetus&#39; exposure to these harmful compounds will be assessed. The influence of exposure to ubiquitous pollutants from the environment, including metal(oids), phthalates, and microplastics, on the synthesis of steroid hormones important for the normal course and outcome of pregnancy will be examined. Furthermore, microplastics in the placenta will be identified and characterized, and its adverse effects on placental function and fetal health will be evaluated. Postnatal health risks due to changes in developmental programming, as a consequence of environmental exposure to metal(oid)s, phthalates and microplastics will be assessed by determining miRNA expression, small non-coding molecules that regulate gene expression. ]]></summary_en></project><project>
<id>17733</id><title_hr><![CDATA[Utjecaj plastifikatora i mikroplastike na reprodukcijsko zdravlje muškaraca]]></title_hr><title_en><![CDATA[]]></title_en><user_id>2649</user_id><user_firstLast_name>Blanka Tariba Lovaković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-8377</code><acronim><![CDATA[PlastRepRisk]]></acronim><duration>10.11.2025 - 09.11.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Institut za medicinska istraživanja i medicinu rada]]></institution_hr><institution_en><![CDATA[Institute for Medical Research and Occupational Health]]></institution_en><team_members_id>872930</team_members_id><team_members_names><![CDATA[ Doktorand: Lucija Kutleša ]]></team_members_names><keywords_hr><![CDATA[plastifikatori, mikroplastika, razvoj metode, reprodukcija, biomonitoring]]></keywords_hr><keywords_en><![CDATA[plasticizers, microplastics, method development, reproduction, biomonitoring]]></keywords_en><summary_hr><![CDATA[Uz dobro poznate ftalatne estere (PAE), organofosfatni esteri (OPE) slabije su istražena klasa plastifikatora koji se zbog svojih svojstava dodaju u brojne uporabne proizvode te su široko rasprostranjeni u okolišu. Sveprisutno su otkriveni u urinu odraslih i djece u općoj populaciji zbog čega privlače sve veću pozornost znanstvene zajednice i regulatornih tijela zaduženih za zaštitu i očuvanje okoliša i zdravlja ljudi. Osim toga, globalni porast upotrebe jednokratnih plastičnih proizvoda izazvao je golem porast izloženosti ljudi mikroplastici (MP). Jedan od glavnih ciljeva projekta PlastRepRisk je uspostaviti analitičku platformu za određivanje plastifikatora (OPE, PAE) i čestica MP u složenim uzorcima ljudske krvi (seruma) i urina kako bi dobili prve podatke o razinama izloženosti opće populacije u Hrvatskoj spojevima OPE i PAE te česticama MP. Iako njihovi učinci na zdravlje još nisu u potpunosti razjašnjeni, za pojedine spojeve OPE i PAE te MP postoji sumnja da djeluju kao endokrini disruptori i/ili štetno utječu na reprodukcijsko zdravlje. U ovom istraživanju ispitat će se i rizici za muško reprodukcijsko zdravlje usporedbom ispitanika s dijagnozom neplodnosti i kontrolnih (zdravih) ispitanika. Kako bismo istražili hipotezu da izloženost spojevima OPE i PAE, te česticama MP može nepovoljno utjecati na plodnost, ispitat će se korelacije između koncentracija odabranih spojeva OPE i PAE te MP u krvi/urinu i neplodnosti koju karakterizira mali broj i/ili loša kvaliteta spermija i poremećaj u razinama spolnih hormona. Osim prvih podataka o razinama izloženosti hrvatske populacije (muškaraca reproduktivne dobi) spojevima OPE i PAE te MP, istraživanje će dati ključna saznanja o njihovom mogućem utjecaju na poremećaj reprodukcijskog zdravlja u uvjetima stvarnih razina izloženosti.]]></summary_hr><summary_en><![CDATA[Along with the well-known phthalate esters (PAE), organophosphate esters (OPE) are a less researched class of plasticizers. Due to their properties, they are frequently added to consumer products, which is the main reason of the compounds&#39; widespread migration in the environment. The detection of PAEs and OPEs in the urine of the general public (both children and adults) has drawn the attention of scientists and regulatory agencies responsible for protection of human health and environment. Furthermore, the global rise in the use of disposable plastic items has led to an escalation in human contact with microplastics (MP). One of the main objectives of the PlastRepRisk project is to establish an analytical platform for analyzing plasticizers (OPE, PAE) and MP particles in complex matrices such as human blood serum and urine. Main goal is to obtain preliminary data on the levels of exposure of the general population in Croatia to OPE and PAE compounds and MP particles. Although their health effects have not yet been fully elucidated, certain OPE and PAE compounds, as well as MPs, are suspected to act as endocrine disruptors and/or have detrimental effects on reproductive health. This study will also evaluate the risks to male reproductive health by comparing men diagnosed with infertility to healthy (control) subjects. Correlations between the concentrations of specific OPE, PAE, and MPs in blood/urine and infertility defined as a low count and/or poor quality of sperm and disruption in sex hormone levels will be assessed in order to investigate the hypothesis that exposure to plasticizers/MP may adversely affect reproductive function. The research will provide key insights into the possible impact of OPE, PAE, and MPs exposure on reproductive health disorders under actual exposure levels, in addition to obtaining first data on the levels of exposure of the Croatian population (men of reproductive age) to these compounds/particles.]]></summary_en></project><project>
<id>17735</id><title_hr><![CDATA[Novel perovskite solar cells with enhanced performance based on hybrid halide perovskite/transition-metal disulfides nanocomposites (Sol-HP-TMD-NanoComp)]]></title_hr><title_en><![CDATA[]]></title_en><user_id>12522</user_id><user_firstLast_name>Krunoslav Juraić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-2241</code><acronim><![CDATA[]]></acronim><duration>08.01.2026 - 07.01.2031</duration><status>U tijeku</status><financ_value>60,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>873016</team_members_id><team_members_names><![CDATA[ Doktorand: Lucija Klobučar ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>17736</id><title_hr><![CDATA[Ruralna transformacija: razvoj i jačanje kapaciteta hrvatskih ruralnih socijalno-ekoloških sustava za transformativnu prilagodbu i otpornost]]></title_hr><title_en><![CDATA[Rural transformation: Developing and strengthening the capacity of Croatian rural social-ecological systems for transformative adaptation and resilience]]></title_en><user_id>5335</user_id><user_firstLast_name>Tijana Trako Poljak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-8001</code><acronim><![CDATA[TRANSFORM_RURAL]]></acronim><duration>01.12.2025 - 30.11.2028</duration><status>U tijeku</status><financ_value>199.163,79 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Sociologija, Interdisciplinarne društvene znanosti, </scie_field_hr><scie_field_en>Sociology, Interdisciplinary social sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>26673, 855432, 26402, 21224, 858328, 870487, </team_members_id><team_members_names><![CDATA[Krešimir Žažar, Vladimir Ivanović, Mateja Jež Rogelj, Anita Bušljeta Tonković, Bruno Šimac, Fanny Frick-Trzebitzky, ]]></team_members_names><keywords_hr><![CDATA[transformativna prilagodba, transformativna otpornost, socijalno-ekološki sustavi, ruralni razvoj, održivost, ruralna područja, Hrvatska]]></keywords_hr><keywords_en><![CDATA[transformative adaptation, transformative resilience, social-ecological systems, rural development, sustainability, rural areas, Croatia]]></keywords_en><summary_hr><![CDATA[U europskim i međunarodnim strategijama, sve se više prepoznaje ključna uloga ruralnih područja i stanovništva kao čuvara kulturne baštine i prirodnih resursa, proizvođača zdrave hrane te aktivnih nositelja vlastitog razvoja. Pri tome se ističe potreba jačanja njihove otpornosti kako bi se uspješno nosili sa suvremenim socijalnim i ekološkim poremećajima. No, najnovija literatura naglašava i važnost procesa ruralne transformacije, koji umjesto kratkoročnog snalaženja zahtjeva razvijanje i jačanje kapaciteta transformativne prilagodbe i otpornosti prema dugoročnom održivom ruralnom razvoju. U isto vrijeme, posljednjih desetljeća u Hrvatskoj opada znanstveni interes za istraživanja ruralnih prostora pa nedostaje sustavnih projekata koji bi pratili ova suvremena kretanja kao i specifične izazove s kojima se suočavaju. Cilj je ovog projekta interdisciplinarnim pristupom primjenom modela ruralnih socijalno-ekoloških sustava (RSES) doprinijeti toj literaturi te empirijski istražiti fenomen ruralne transformacije u Hrvatskoj, kroz razvoj strategija za jačanje transformativne sposobnosti hrvatskih RSES-ova u odgovoru na suvremene socijalno-ekološke izazove. U ostvarenju projektnog cilja, koristit će se kvalitativni i kvantitativni pristupi i mješovite metode u tri istraživačke dionice koje odgovaraju trima fazama razvijanja transformativne prilagodbe u literaturi: (1) „desk“ metoda i dubinski intervjui uz fotografsku elicitaciju, kako bi se izgradio „socijalno-ekološki inventar“; (2) fokus grupe i radionice sa stanovnicima i dionicima u tri studije slučaja hrvatskih RSES-ova, kako bi se primjenom SES modela razvila održiva rješenja; i (3) anketa o ruralnoj transformaciji na reprezentativnim uzorku tri odabrane regije. Projekt je teorijski i metodološki inovativan te se očekuje da će rezultati doprinijeti literaturi o RSES-ovima i ruralnoj transformaciji, a oblikovana rješenja informirati stručnjake za učinkovitije strategije razvoja otpornih i naprednih ruralnih područja.]]></summary_hr><summary_en><![CDATA[European and international development programs increasingly recognize the key role of rural areas and populations as custodians of cultural heritage and natural resources, producers of healthy food and active agents of their own development. At the same time, the need to strengthen their resilience to successfully cope with social and environmental disruptions is emphasized. However, more recent literature also emphasizes rural transformation, which requires the development and strengthening of capacities for transformative adaptation and resilience towards long-term sustainable rural development, not just short-term coping. At the same time, scientific interest in rural areas has decreased in Croatia in recent decades, resulting in a lack of studies of contemporary issues as well as the specific challenges they face. The aim of this project is to contribute to this literature by applying an interdisciplinary approach of the rural social-ecological systems (RSES) model and empirically investigating the phenomenon of rural transformation in Croatia by developing strategies to strengthen the transformative capacity of Croatian RSESs in response to contemporary social-ecological challenges. To achieve this, qualitative and quantitative approaches and mixed methods will be used in three research stages, corresponding to the phases of transformative adaptation development: (1) &#39;&#39;desk&#39;&#39; method and in-depth interviews with photo elicitation, to create a &#39;&#39;social-ecological inventory&#39;&#39;; (2) focus groups and workshops with residents and stakeholders in three rural case studies, to develop sustainable solutions by applying the SES model; and (3) rural transformation on a representative sample of three rural regions. The project is theoretically and methodologically innovative and the results are expected to contribute to the literature on RSESs and rural transformation and inform experts on more effective strategies for the development of resilient and thriving rural areas.]]></summary_en></project><project>
<id>17738</id><title_hr><![CDATA[Dinamika kompleksnih femtosustava]]></title_hr><title_en><![CDATA[Dynamics of complex femtosystems]]></title_en><user_id>780</user_id><user_firstLast_name>Tamara Nikšić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-4214</code><acronim><![CDATA[DynFem]]></acronim><duration>30.12.2025 - 29.12.2028</duration><status>U tijeku</status><financ_value>173.725,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>24, </team_members_id><team_members_names><![CDATA[Dario Vretenar, ]]></team_members_names><keywords_hr><![CDATA[Nuklearna fisija,Energijski funkcionali gustoće,Reakcije prijenosa nukleona,Vremenski ovisan Hartree-Fock-Bogoliubov račun,Nuklearna kvazifisija]]></keywords_hr><keywords_en><![CDATA[Nuclear fission,Energy density functionals,Multinucleon transfer reactions,Time-dependent Hartree-Fock-Bogoliubov method,Nuclear quasifission,]]></keywords_en><summary_hr><![CDATA[Dinamika kvantih sustava mnoštva čestica predstavlja bogato interdisciplinarno područje istraživanja. Vremenska evolucija sustava većeg broja međudjelujućih čestica pokazuje mnoštvo zanimljivih i složenih pojava, kao npr. međuigra kolektivnih i jednočestičnih stupnjeva slobode, neravnotežna dinamika (termalizacija, kvantni kaos), unitarna evolucija u izoliranim sustavima, isprepletenost, disipativna dinamika otvorenih sustava. Navedene pojave karakteriziraju složene sustave u fizici visokih energija, nuklearnoj, atomskoj i molekulskoj fizici, fizici kondenzirane tvari, te Bose-Einstein kondenzatima.Na femtoskali, atomske jezgre predstavljaju samo-vezane mezoskopske sustave sastavljene od konačnog i relativno malog broja fermiona: protona i neutrona. Struktura, stabilnost, struktura i dinamika atomskih jezgara određene su nadmetanjem jakog, slabog i elektromagnetskog međudjelovanja. Stoga atomske jezgre pokazuju sve osobine kompleksnih kvantnih sustava. Cilj ovog projekta je proučiti dinamiku atomske jezgre na niskim i srednjim energijama. Preciznije, razvit će se novi koncepti i metode, zajedno s pratećim računalnim kodovima, za modeliranje složene dinamike pojava u atomskim jezgrama: inducirane fisije, sudara teških iona, reakcija prijenosa nukleona, kvazifisije, isprepletenosti i entropije u nuklearnim reakcijama.]]></summary_hr><summary_en><![CDATA[The dynamics of quantum many-body systems is a rich and interdisciplinary field. The time evolution and behavior of systems composed of a large number of interacting quantum particles presents many interesting complex phenomena, such as the interplay between collective motion and single-particle degrees of freedom, nonequilibrium dynamics (thermalization, quantum chaos), unitary evolution in isolated systems, entanglement, quantum quenches, dissipative dynamics in open systems. These phenomena characterize composite systems in high-energy physics, nuclear, atomic and molecular physics, condensed matter, Bose-Einstein condensates. On the femtoscale, atomic nuclei are self-bound mesoscopic systems composed of a finite and relatively small number of fermions: protons and neutrons. The structure, stability, composition and dynamics of nuclei are determined by the interplay of strong, weak and electromagnetic interactions. This is the reason nuclei exhibit all characteristics of complex quantum systems. The objective of this project is to study nuclear dynamics at low and intermediate energies. More specifically, new concepts and methods will be developed, together with the corresponding computer codes, for modelling complex time-dependent nuclear phenomena: induced fission, heavy-ion collisions and multi-nucleon transfer reactions, quasifission reactions, entanglement and entropy production in nuclear reactions.]]></summary_en></project><project>
<id>17741</id><title_hr><![CDATA[AELECTRA - A new concept for mid- to long-term storage of electrical energy in ammonia]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5203</user_id><user_firstLast_name>Helena Otmačić Ćurković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-4990</code><acronim><![CDATA[]]></acronim><duration>01.12.2025 - 30.11.2031</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Kemijsko inženjerstvo, </scie_field_hr><scie_field_en>Chemical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet kemijskog inženjerstva i tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Chemical Engineering and Technology]]></institution_en><team_members_id>872924</team_members_id><team_members_names><![CDATA[ Doktorand: Lana Brkić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>17743</id><title_hr><![CDATA[Poticanje otkrića u području bezolovnih hibridnih molekulskih feroelektrika pod visokim tlakom]]></title_hr><title_en><![CDATA[Prompting breakthroughs in the field of lead-free hybrid molecular ferroelectrics under high pressure]]></title_en><user_id>13002</user_id><user_firstLast_name>Martina Vrankić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-1350</code><acronim><![CDATA[ProBreLFHMFsHiPre]]></acronim><duration>12.01.2026 - 11.01.2029</duration><status>U tijeku</status><financ_value>199.985,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, Fizika, </scie_field_hr><scie_field_en>Chemistry, Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>11146, 867690, 867918, 21309, </team_members_id><team_members_names><![CDATA[Jasminka Popović, Takeshi Nakagawa, Dominique Laniel, Valentina Milašinović, ]]></team_members_names><keywords_hr><![CDATA[bezolovni hibridni molekulski feroelektrici, visoki tlak, rješavanje kristalne strukture, odnos struktura-svojstvo, fazni prijelaz, energijski procjep]]></keywords_hr><keywords_en><![CDATA[lead-free hybrid molecular ferroelectrics, high-pressure, crystal structure solution, structure-property relationship, phase transition, band gap]]></keywords_en><summary_hr><![CDATA[Kemijskom sintezom i primjenom visokog tlaka kao postsintetskim parametrom (uz primjenu tehnolgije dijamantne ćelije) i najsuvremenijih mjerenja strukturnih/fizičkih svojstava, projekt će unaprijediti znanost o materijalima stvaranjem poboljšanih, do sada neistraženih svojstava. Istraživačka skupina pripremit će hibridne organsko-anorganske molekulske feroelektrike jednostavnom, otopinskom kemijom. S obzirom na do sada uočene karakteristike ovih materijala, čini se da je njihov razvoj dosegao plato. Karakterističan pristup rješavanju ovog problema uključuje primjenu tlaka za promjenu svojstava postojećih hibridnih organsko-anorganskih molekulskih feroelektrika. Tlak je učinkovit i čist alat kojim se može postići elegantno preoblikovanje hibridnih molekulskih feroelektrika, odnosno precizno reguliranje njihove kristalne rešetke i elektronskog ponašanja na atomskoj razini, što dovodi do podešenih ključnih svojstava materijala. Sužavanje energijskog procijepa, poboljšanje intenziteta fotoluminiscencije, zadržavanje visokotlačne faze na ambijentalnim uvjetima, pojave metalizacije, amorfizacije i faznih prijelaza značajke su koje proširuju mogućnosti primjene ovih materijala, ali su do sada uglavnom bile rezervirane za dobro proučene hibridne molekulske feroelektrike koji sadrže olovo, a koji su toksični i suštinski pate od ozbiljnih problema sa stabilnošću. Kao rezultat toga, ključno je bolje razumjeti vezu između strukture i svojstava u bezolovnim hibridnim molekulskim feroelektricima i povezati najbolja i najstabilnija svojstva ovih materijala sa specifičnim strukturnim informacijama. To je od ključne važnosti ne samo za temeljna znanstvena istraživanja, već i za praktičnu primjenu, jer je razvoj bezolovnih, hibridnih, zamjenjivih materijala s netoksičnim ili manje toksičnim komponentama uz održavanje izvrsne dugoročne funkcionalnosti trenutno jedan od najvećih izazova u području fotonaponskih sustava.]]></summary_hr><summary_en><![CDATA[Through chemical synthesis and a high-pressure post-synthesis treatment using a diamond anvil cell and cutting-edge structural/physical property measurements, the project will advance material discovery by creating improved materials. The research group will prepare lead-free hybrid molecular ferroelectrics (LFHMFs) derived from flexible inorganic anions and a light cationic moiety using a facile solution chemistry approach. Given the characteristics of LFHMFs observed thus far, it appears that their development has reached a plateau. A distinctive approach to addressing this issue involves the use of pressure to alter the characteristics of existing LFHMFs. Pressure is an effective and clean post-synthesis tool for the elegant reshaping of LFHMFs, used to accurately regulate their crystal lattice and electronic behavior with atomic-level knowledge, leading to tuned key material properties. The narrowing of the band gap, carrier-lifetime prolongation, photoluminescence intensity enhancement, ambient-memorized retainability, metallization, amorphization, and phase transitions are features that expand the application possibilities of hybrid molecular ferroelectrics (HMFs), but have so far been mainly reserved for the well-studied lead-containing HMFs, which are toxic and intrinsically suffer from severe stability issues. As a result, it is critical to get a better understanding of the link between structure and property in LFHMFs and connect the best and most stable materials&#39; properties with specific structural information. This is of crucial importance not only for fundamental scientific research but also for practical applications, as the development of lead-free, hybrid, switchable materials with non-toxic or less toxic components while maintaining excellent long-term functionality is currently one of the greatest challenges in the field of photovoltaics.]]></summary_en></project><project>
<id>17746</id><title_hr><![CDATA[Nova strategija za procjenu razina ozona i utjecaja na mediteranske šumske ekosustave]]></title_hr><title_en><![CDATA[New strategy for assessment of Ozone levels and impacts on Mediterranean Forest ecosystems ]]></title_en><user_id>6636</user_id><user_firstLast_name>Tamara Jakovljević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-9936</code><acronim><![CDATA[O3MedFor]]></acronim><duration>31.12.2025 - 30.12.2028</duration><status>U tijeku</status><financ_value>185.380,00 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Šumarstvo, </scie_field_hr><scie_field_en>Forestry, </scie_field_en><institution_hr><![CDATA[Hrvatski šumarski institut]]></institution_hr><institution_en><![CDATA[Croatian Forest Research Institute]]></institution_en><team_members_id>849, 848, 5644, 3501, 25878, 870265, 870607, </team_members_id><team_members_names><![CDATA[Ivan Seletković, Nenad Potočić, Jasnica Medak, Lukrecija Butorac, Ivan Limić, Yasutomo Hoshika, Alessandra De Marco, ]]></team_members_names><keywords_hr><![CDATA[automatske mjerne stanice, ozon, pokazatelji zdravstvenog stanja šuma, P.nigra, Q. pubescens]]></keywords_hr><keywords_en><![CDATA[active monitoring stations,  forest-health indicators, ozone, P.nigra, Q.pubescens]]></keywords_en><summary_hr><![CDATA[Klimatske promjene i onečišćenje zraka dva su važna međusobno povezana uzročnika stresa koji utječu na bioraznolikost šuma i na održivo gospodarenje šumama EU. Jedan od najvažnijih prijetnji  je troposferski ozon (O3). Trenutne razine O3 dovoljno su visoke da negativno utječu na drveće izazivajući npr. vidljive simptome lišća, smanjujući folijarni sadržaj klorofila, ubrzavajući starenje lišća, smanjujući fotosintezu, rast i sekvestraciju ugljika. Najviša razina O3 zabilježena je u Sredozemlju i srednjoj Europi, a koncentracije O3 premašile su 40 ppb na 37,3 % šumskih područja. Epidemiološke studije u kojima se uspoređuju biološki odgovori s podacima s terena, mogu pružiti korisne informacije za utvrđivanje najboljih standarda i pragova za zaštitu šuma od O3 i izračun novih kritičnih razina na temelju toka kroz puči. Još uvijek nedostaje validacija pragova u različitim vanjskim uvjetima. Stoga su potrebna daljnja istraživanja u mediteranskim uvjetima koja kombiniraju praćenje ozona s pokazateljima zdravlja šuma kako bi se dublje razumio njegov utjecaj na tipične šumske ekosustave duž jadranske obale (P. nigra i Q. pubescens). S obzirom na činjenicu da se koncentracije i utjecaji  ozona u šumama ne mogu lako pratiti, projekt O3MedFor predlaže razvoj inovativnog pristupa praćenju s automatskim O3 monitorima sa solarnim panelima. Istraživanje pokazatelja zdravstvenog odgovora šuma na O3 zajedno s opsežnim skupovima podataka novopostavljenih automatskih stanica za praćenje,  izračuni izloženosti ozonu i standardi temeljeni na tokovima te procjena maksimalnih razina ozona koje šumski ekosustav može tolerirati, podići će se svijest javnosti o onečišćenju O3 i njegovim posljedicama. Kako je istaknuto u najnovijoj direktivi EU-a o kvaliteti zraka i čišćem zraku (2024/2881/EU), ti su pokazatelji i standardi potrebni i za poboljšanje praćenja učinaka onečišćujućih tvari u zraku na ekosustave i procjenu učinkovitosti strategija kontrole onečišćenja zraka u EU-u.]]></summary_hr><summary_en><![CDATA[Climate change and air pollution are two significant interacting stressors affecting forest biodiversity and the sustainable management of EU forests. One of the most important threats is tropospheric ozone (O3). Current O3 levels are high enough to negatively affect trees by inducing e.g. visible leaf symptoms, decreasing foliar chlorophyll content, accelerating leaf senescence, decreasing photosynthesis, growth and carbon sequestration. The highest levels of O3 were recorded in the Mediterranean and Central Europe and O3 concentrations exceeded 40 ppb on 37.3 % of forest sites. Epidemiological studies, where biological responses are compared with field data, may provide useful information for establishing the best standards and thresholds for forest protection and deriving new stomatal flux-based critical levels. Validation of thresholds under different field conditions is still missing. Therefore, further studies under Mediterranean field conditions that combine ozone monitoring with forest-health indicators for a deeper understanding of its impact on typical forests along the Adriatic coast (P. nigra and Q. pubescens) is needed. Given the fact that concentrations and impacts cannot be easily monitored in forests, O3MedFor project proposes to develop an innovative monitoring approach of measuring, active O3 monitors with solar panels. Investigation of forest-health response indicators together with comprehensive datasets of newly installed active monitoring stations, calculation of ozone-exposure and flux-based standards and estimation of maximum levels of ozone that the forest ecosystem can tolerate, will raise awareness to public about O3 pollution and impacts. As highlighted in the latest EU directive on ambient air quality and cleaner air (2024/2881/EU), these indicators and standards are also needed to improve monitoring of the effects of air pollutants on ecosystems and to assess the effectiveness of air pollution control strategies in EU.]]></summary_en></project><project>
<id>17749</id><title_hr><![CDATA[Fizika mekih fonona i elektron-fonon fluktuacije u slojevitim dvodimenzionalnim sustavima]]></title_hr><title_en><![CDATA[Soft-phonon physics and electron-phonon fluctuations in layered two-dimensional systems]]></title_en><user_id>26143</user_id><user_firstLast_name>Dino Novko</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-5926</code><acronim><![CDATA[SoftFlu]]></acronim><duration>12.12.2025 - 11.12.2028</duration><status>U tijeku</status><financ_value>180.315,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut za fiziku]]></institution_hr><institution_en><![CDATA[Institute of Physics in Zagreb]]></institution_en><team_members_id>865259, 855985, 868073, 4933, </team_members_id><team_members_names><![CDATA[Raffaello Bianco, Nina Girotto Erhardt, Emmanuele Cappelluti, Vito Despoja, ]]></team_members_names><keywords_hr><![CDATA[meki fononi, fluktuacije, elektron-fonon vezanje, val gustoće naboja, dihalkogenidi prijelaznih metala, 2D materijali, teorija funkcionala gustoće]]></keywords_hr><keywords_en><![CDATA[soft phonons, fluctuations, electron-phonon coupling, charge density waves, transition metal dichalcogenides, 2D materials, density functional theory]]></keywords_en><summary_hr><![CDATA[Razumijevanje nekonvencionalnih uređenih stanja u koreliranim kvantnim materijalima jedan je od glavnih ciljeva fizike kondenzirane tvari, te bi nam mogao dati smjernice za kontroliranu manipulaciju tehnološki poželjnih faza materije, kao što su supravodljivost i valovi gustoće naboja (CDW). Ključ za otkrivanje misterija ovih stanja je razumijevanje &#39;&#39;normalne&#39;&#39; faze iz koje nekonvencionalne faze proizlaze, te za koju se obično vjeruje da je pod utjecajem fluktuacija mnogočestičnih interakcija. Ovaj projekt će se baviti ovom potragom i izvesti opsežan teorijski pregled fenomena uređenih stanja naboja, dinamike mekih fonona i fluktuacija povezanih s elektron-fonon vezanjem u koreliranim kvazi-dvodimenzionalnim dihalkogenidima prijelaznih metala (TMD). Međudjelovanje korelacija elektrona i rešetke u dopiranim TMD-ovima rezultira širokim spektrom isprepletenih uređenih stanja kao što su pseudo-procjep (PG), CDW i supravodljivost. U usporedbi s posljednje dvije faze, PG i pripadajući uzrok manje su proučavani unatoč njegovoj važnosti u razumijevanju nekonvencionalne supravodljivosti i njezine univerzalnosti u koreliranim sustavima. Projekt predlaže metodologiju baziranu na prvim principima koja uključuje više redove elektron-fonon fluktuacija, te koja će moći precizno opisati zagonetna uređena stanja, meke fonone i elektron-fonon dinamiku u raznim TMD-ovima. Osim osnova CDW i PG fluktuacija, projekt planira istražiti transportna i optička svojstva te interakciju svjetlosti i tvari preko faznog dijagrama TMD-ova koji podržavaju CDW fazu. Ovime ćemo postaviti potrebne smjernice za različite optičke spektroskopije i transportna mjerenja u ispitivanju fluktuacija i uređenih stanja naboja, kao i istražiti potencijal koreliranih TMD-ova i CDW pobuda kao nove platforme za manipulaciju svjetlošću i plazmonike s malim gubicima.]]></summary_hr><summary_en><![CDATA[Comprehending unconventional ordered states in correlated quantum materials is one of the prime goals of condensed matter physics, which could provide us with the guidelines for controllable manipulation of the technologically desirable phases of matter, such as superconductivity and charge density waves (CDW). A key to unlock the mysteries of these states is to understand the “normal” phase from which they emerge, usually believed to be dominated by fluctuations of many-body interactions. The present project will take this quest and perform a comprehensive theoretical survey of charge-order phenomena, dynamics of soft phonons, and electron-phonon-related fluctuations in correlated quasi-two-dimensional transition metal dichalcogenides (TMDs). The interplay of electron and lattice correlations in doped TMDs results in a wide spectrum of intertwined ordered states such as pseudogap (PG), CDW and superconductivity. Compared to the latter two phases, the PG and the corresponding origin are less studied despite its importance in understanding the unconventional superconductivity and its universality across the correlated systems. The project proposes a first-principles methodology that incorporates higher-order electron-phonon fluctuations, which will be able to accurately describe the puzzling charge-order states, soft phonons, and electron-lattice dynamics in various TMDs. Besides the fundamentals of CDW and PG fluctuations, the project plans to explore the transport, optical properties, and light-matter interaction across the phase diagram of CDW-bearing TMDs. With this we will lay down necessary guidelines for various optical spectroscopies and transport measurements in probing the fluctuations and charge-order states, as well as explore the potential of the correlated TMDs and charge-order excitations as a new platform for light manipulation and low-loss plasmonics.]]></summary_en></project><project>
<id>17754</id><title_hr><![CDATA[UWIN-LABUST - ERA Chair in Internet of Underwater Things at LABUST]]></title_hr><title_en><![CDATA[]]></title_en><user_id>20001</user_id><user_firstLast_name>Đula Nađ</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-3374</code><acronim><![CDATA[]]></acronim><duration>01.03.2026 - 29.02.2032</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>873089</team_members_id><team_members_names><![CDATA[ Doktorand: Tarik Krivošija ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>17760</id><title_hr><![CDATA[Otkrivanje biomarkera za bolest Hashimotov tireoiditis koristeći multi-omics pristup]]></title_hr><title_en><![CDATA[]]></title_en><user_id>63</user_id><user_firstLast_name>Vesna Boraska Perica</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-3872</code><acronim><![CDATA[HT-OMICS]]></acronim><duration>01.12.2025 - 01.12.2031</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Split School of Medicine]]></institution_en><team_members_id>872907</team_members_id><team_members_names><![CDATA[ Doktorand: Ivana Listeš ]]></team_members_names><keywords_hr><![CDATA[Hashimotov tireoiditis, multi-omics, genetika, proteomika, metabolomika, biomarkeri, Mendelova randomizacija, zonulin]]></keywords_hr><keywords_en><![CDATA[Hashimoto&#39;s thyroiditis, multi-omics, genetics, proteomics, metabolomics, biomarkers, Mendelian randomisation, zonulin]]></keywords_en><summary_hr><![CDATA[Hashimotov tireoiditis (HT) je najučestalija autoimuna bolest današnjice. Molekularni mehanizmi koji stoje u podlozi bolesti još uvijek nisu dovoljno poznati, stoga je ovaj projekt usmjeren na otkrivanje novih znanja o molekularnim i biološkim putovima vezanim uz HT. Ovaj projekt predstavlja nastavak prethodne HRZZ Uspostavne potpore u kojoj je osnovana CRO-HT biobanka bioloških uzoraka i fenotipova za 500 ispitanika oboljelih od HT-a te je na njima provedena cjelogenomska analiza povezanosti (GWAS). U međuvremenu smo prikupili još 200 kontrolnih ispitanika te u predloženom projektu kroz cilj 1 (C1 Proširenje CROHT biobanke) planiramo uključiti dodatnih 200 ispitanika s HT-om te genotipizirati njihov genom. Također, planiramo mjeriti i analizirati proteinske i metaboličke markere kroz ciljeve 2 (C2 Otkrivanje biomarkera koristeći proteomsko profiliranje) i 3 (C3 Otkrivanje biomarkera koristeći metabolomsko profiliranje). Kroz ove ciljeve ćemo nastojati: (a) identificirali različito izražene proteinske/metaboličke markere između HT ispitanika i kontrola i ispitati povezanost omics profila s težinom bolesti HT; (b) utvrditi povezanosti između značajnih markera i kliničkih obilježja HT-a; (c) integrirati sve dostupne omics podatke (cjelogenomske genotipove, proteom i metabolom) da bi dobili bolji uvid u manifestaciju same bolesti; (d) ispitati postojanje uzročnih povezanosti između značajnih markera (metabolita i proteina) i HT-a koristeći metodu Mendelove randomizacije. Kroz posljednji cilj 4 (C4 Istraživanje uloge crijevne propusnosti s HT-om) planiramo mjerenje i analiziranje proteina zonulina  koji je trenutno jedini mjerljivi marker crijevne propusnosti. Predloženi sveobuhvatni istraživački pristup pridonijet će razumijevanju temeljnih bioloških putova povezanih s mehanizmima nastanka HT-a i identifikaciji biomarkera koji mogu služiti pri stvaranju prediktivnih modela za rizik od HT-a te do razvoja novih terapijskih, prevencijskih i dijagnostičkih metoda.]]></summary_hr><summary_en><![CDATA[Hashimoto&#39;s thyroiditis (HT) is the most common autoimmune disease today. The molecular mechanisms underlying the disease are still not sufficiently known, therefore this project is aimed at discovering new knowledge related to the molecular and biological pathways related to HT. This project is a continuation of the previous HRZZ Installation Grant, in which we formed the CRO-HT biobank of biological samples and phenotypes for 500 patients with HT and performed a GWAS of this disease. In the meantime, we have collected another 200 control individuals. In the proposed project, through objective 1 (O1 Expansion of the CROHT biobank), we plan to include an additional 200 subjects with HT and to genotype their genome. Also, we plan to measure and analyze protein and metabolic markers through objectives 2 (O2 Proteomic profiling of HT for biomarker discovery) and 3 (O3 Metabolomic profiling of HT for biomarker discovery). Through these objectives, we will try to: a) Identify differentially expressed proteome/metabolome biomarkers between HT cases and controls  and examine omics profiles with HT disease severity, (b) Assess associations between significant biomarkers and clinical features of HT, (c) Integrate all available omics data (genome wide genotypes, proteome and metabolome) to gain deeper insights in disease manifestation, (d) Examine causal relationships between significant biomarkers (metabolites and proteins) and HT using Mendelian randomization. Through the last objective 4 (O4 Evaluation of the role of intestinal wall permeability with HT) we plan to measure and analyse the protein zonulin, which is currently the only measurable marker of intestinal wall permeability. With the proposed comprehensive research, we strive to produce broader knowledge on molecular pathophysiology, diseases biomarkers, predictive models and potential therapeutics to accelerate the implementation of personalised medicine in clinical practice.]]></summary_en></project><project>
<id>17763</id><title_hr><![CDATA[Samoorganizirajući derivati diamantoida za molekularno skladištenje energije]]></title_hr><title_en><![CDATA[Self-organizing diamondoid derivatives for molecular energy storage]]></title_en><user_id>2988</user_id><user_firstLast_name>Marina Šekutor</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-4455</code><acronim><![CDATA[MOSTDIA]]></acronim><duration>31.01.2026 - 30.01.2029</duration><status>U tijeku</status><financ_value>199.870,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>3215, 3336, 2992, </team_members_id><team_members_names><![CDATA[Marija Alešković, Margareta  Sohora, Tatjana Šumanovac, ]]></team_members_names><keywords_hr><![CDATA[diamantoidi, sustavi molekularnog skladištenja energije (MOST), norbornadien-kvadriciklan par, samoorganizacija na površinama, kovalentni sustavi]]></keywords_hr><keywords_en><![CDATA[diamondoids, molecular solar thermal (MOST) energy storage systems, norbornadiene-quadricyclane pair, on-surface self-assembly, covalent assemblies]]></keywords_en><summary_hr><![CDATA[Sustavi za molekularnu pohranu solarne toplinske energije (MOST) temeljeni na paru norbornadien-kvadriciklan (NK) obećavajući su materijali sljedeće generacije za iskorištavanje sunčeve energije zbog svog visokog kapaciteta za skladištenje energije te reverzibilnosti reakcije fotoizomerizacije, što omogućava ponavljajuće cikluse pretvorbe energije iz solarne u kemijsku i zatim u toplinu. Međutim, samo nekoliko nedavnih primjera spominje sustav NK koji je položen na čvrstom nosaču (metali, grafit), pri čemu se povratna reakcija postiže katalitički (metalnom površinom) ili elektrokatalitički (razlikom potencijala). Naš inovativni pristup podrazumijeva skupljanje, skladištenje i zatim oslobađanje energije putem monoslojeva na površinama, za što ćemo koristiti kombinaciju NK prijamnika za zračenje s diamantoidnim sidrima. Diamantoidi su kavezasti ugljikovodici koji se mogu selektivno funkcionalizirati te se često koriste kao građevni elementi prilikom dizajna nanomaterijala, a mogu se samoorganizirati na površinama u uređene 2D monoslojeve zbog Londonovih disperzijskih interakcija koje djeluju između njih. Prethodno smo predstavili novi pristup za konstrukciju većih diamantoidnih sustava pripravom diamantoida s heteroatomskim poveznicama. Sada ćemo pripraviti novu klasu diamantoidno-norbornadienskih spojeva, položiti ih na površine (metali, grafit, itd.), proučavati njihovu spontanu samoorganizaciju na površinama (eksperimentalno i računalno) te istražiti njihovu primjenjivost za molekularnu pohranu energije provođenjem odgovarajućih analitičkih mjerenja. Očekujemo da će diamantoidne MOST molekule posjedovati povećanu mogućnost slaganja na površinama (uređeni monoslojevi), izdržljivost (zanemariv raspad materijala), upravljivost (modulacija razlikom potencijala) i selektivnost (jednostavna kemijska interkonverzija između fotoizomera), što vodi ka primjenjivim MOST uređajima poput organskih solarnih baterija/generatora rada.]]></summary_hr><summary_en><![CDATA[Molecular solar thermal (MOST) energy storage systems based on the norbornadiene-quadricyclane pair show promise as next generation solar energy harvesting materials due to high energy storage capacity and reversibility of the photoisomerization reaction that enables repeating cycles and continuous conversion of sunlight to heat. Only a few recent reports explore the norbornadiene-quadricyclane system on a solid support (metals, HOPG), noting that the back-conversion reaction can be performed catalytically (by a metal surface) or electrocatalytically (by applying potential). Our cutting edge approach is to harvest, store and release energy using molecular monolayers on surfaces, and for that we will combine the norbornadiene-quadricyclane antenna with diamondoid anchor units. Diamondoids, cage hydrocarbons that can be selectively chemically functionalized, are used as molecular building blocks in nanomaterials design and can self-assemble on surfaces to form ordered 2D monolayers due to London dispersion interactions acting between them. We previously introduced a new approach to constructing larger diamondoid systems by preparing diamondoid covalent assemblies with a heteroatom linker. Here we will synthesize novel diamondoid norbornadiene compound classes, deposit them on surfaces (metals, HOPG, etc.), study their spontaneous on-surface self-assembly (experimentally and computationally) and evaluate their applicability as MOST energy storage candidates by performing appropriate analytical measurements. Diamondoid MOST molecules are envisioned to possess increased system on-surface assembly (ordered monolayer formation), durability (negligible material decomposition), controllability (modulation with applied potential) and selectivity (straightforward chemical interconversion between the photoisomers), paving a way towards applicable MOST reactor devices as organic solar batteries/work generators.]]></summary_en></project><project>
<id>17768</id><title_hr><![CDATA[Nove mogućnosti uzgoja u svrhu povećanje prinosa ljekovite jestive gljive resasti igličar (Hericium erinaceus)]]></title_hr><title_en><![CDATA[]]></title_en><user_id>337</user_id><user_firstLast_name>Tihomir Kovač</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-7541</code><acronim><![CDATA[]]></acronim><duration>05.11.2025 - 04.11.2031</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Biotehnologija, </scie_field_hr><scie_field_en>Biotechnology, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Prehrambeno-tehnološki fakultet]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Food Technology]]></institution_en><team_members_id>872886</team_members_id><team_members_names><![CDATA[ Doktorand: Sunčana Gavran ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>17770</id><title_hr><![CDATA[Korištenje umjetne inteligencije za otkrivanje zelenih kemokomunikacijskih disruptora kukaca za održivu zaštitu usjeva]]></title_hr><title_en><![CDATA[Levering AI for discovery of green insect chemocommunication disruptors for sustainable crop protection]]></title_en><user_id>2835</user_id><user_firstLast_name>Višnja Stepanić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-7105</code><acronim><![CDATA[LAIDYGRID]]></acronim><duration>05.12.2025 - 04.12.2028</duration><status>U tijeku</status><financ_value>171.925,00 eur</financ_value><scie_area_hr>Prirodne znanosti, Biotehničke znanosti, </scie_area_hr><scie_area_en>Natural sciences, Biotechnical sciences, </scie_area_en><scie_field_hr>Kemija, Poljoprivreda, </scie_field_hr><scie_field_en>Chemistry, Agriculture, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>864917, 12868, 19317, 19319, 855422, 2509, 2512, </team_members_id><team_members_names><![CDATA[Dalibor Hršak, Darija Lemić, Ivana Pajač Živković, Helena Virić Gašparić, Sandra Skendžić, Senka Djaković, Jasmina Lapić, ]]></team_members_names><keywords_hr><![CDATA[hlapljivi organski spojevi, kemokomunikacija, olfaktorni receptori, smeđa mramorasta stjenica, umjetna inteligencija, molekulsko modeliranje]]></keywords_hr><keywords_en><![CDATA[volatile organic compounds, chemocommunication, olfactory receptors, brown marmorated stink bug, AI, molecular modelling]]></keywords_en><summary_hr><![CDATA[Senzorni kemijski spojevi imaju ključnu ulogu u svim oblicima života. Kukci se uvelike oslanjaju na hlapljive organske spojeve (HOS) kao signalne molekule za komunikaciju. Semiokemikalije, feromoni i alelospojevi reguliraju društveno ponašanje, reprodukciju, potragu za hranom, obranu i navigaciju kukaca. Razumijevanje interakcija HOS-a s olfaktornim receptorima ključno je za dizajniranje novih spojeva koji ometaju kemijsku komunikaciju kukaca. Predloženo istraživanje LAIDYGRID usmjereno je na identifikaciju biljaka, hlapljivih biljnih metabolita i njihovih zelenih sintetskih analoga s disruptivnim djelovanjem na kemokomunikaciju smeđe mramoraste stjenice (H. halys), invazivnog poljoprivrednog štetnika koji uzrokuje značajne gospodarske štete na širokom spektru usjeva, uključujući jabuke, kruške, breskve, soju i povrće. Pristup LAIDYGRID temelji se na razvoju sveobuhvatnog istraživačkog tijeka rada koji integrira AI/ML tehnike s molekularnim modeliranjem temeljenim na strukturi proteina i liganada, uz eksperimentalnu validaciju kroz in vivo bihevioralne bioeseje i in vitro toksikološku procjenu. Predloženo istraživanje je interdisciplinarno i oslanja se na suvremene metode iz područja AI/ML modeliranja, molekularnog uklapanja, farmakofornog modeliranja i MD simulacija, pripreme i analize biljnih ekstrakata, klik kemije, in vitro toksikološkog ispitivanja te in vivo laboratorijskih, poluterenskih i terenskih bioeseja za procjenu utjecaja HOS-a na ponašanje smeđe mramoraste stjenice. Kombiniranjem računalnih modela i empirijske validacije, uz učinkovitu diseminaciju i komunikaciju rezultata, LAIDYGRID će unaprijediti istraživanja u području kemijske komunikacije kukaca i podržati razvoj učinkovitih, ekološki prihvatljivih strategija za smanjenje utjecaja H. halys na poljoprivredu.]]></summary_hr><summary_en><![CDATA[Sensory chemicals play an essential role in all life. Insects rely heavily on volatile organic compounds (VOCs) as signalling molecules for communication. Semiochemicals, pheromones and allelochemicals regulate social behaviour, reproduction, foraging, defence and navigation of insects. Understanding VOCs’ interactions with olfactory receptors is crucial for designing novel disruptors of chemical communication of insects. The proposed research LAIDYGRID aims to identify plants, volatile plant metabolites, and their green synthetic analogues with chemocommunication-disrupting activity on brown marmorated stink bug, H. halys, an invasive agricultural pest causing substantial economic damage to a wide range of crops, including apples, pears, peaches, soybeans, and vegetables. The LAIDYGRID approach is based on developing comprehensive workflow that integrates AI/ML techniques with both structure- and ligand-based molecular modelling methods, and its experimental validation through in vivo behavioural bioassays and in vitro toxicological assessment. The proposed research is interdisciplinary and based on the state-of-the-art methods from the fields of AI/ML modelling, molecular docking, pharmacophore modelling and MD simulations, plant extract preparation and analysis, click chemistry, in vitro toxicological screening and in vivo laboratory, semi-field and field bioassays to assess the impact of VOCs on stink bug behaviour. By combining computational models with empirical validation, along with effective dissemination and communication of results, LAIDYGRID will advance research in insect chemical communication and support the development of efficient, environmentally friendly strategies to mitigate the impact of H. halys on agriculture. ]]></summary_en></project><project>
<id>17774</id><title_hr><![CDATA[Sveobuhvatna analiza odgovora stanice domaćina na infekciju adenovirusom čovjeka tip 26]]></title_hr><title_en><![CDATA[Comprehensive analysis of host cell response to human adenovirus type 26 infection]]></title_en><user_id>12819</user_id><user_firstLast_name>Dragomira Majhen</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-3470</code><acronim><![CDATA[AdenoHost]]></acronim><duration>05.12.2025 - 04.12.2028</duration><status>U tijeku</status><financ_value>199.955,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, Interdisciplinarne prirodne znanosti, </scie_field_hr><scie_field_en>Biology, Interdisciplinary natural sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>23338, 21332, 867982, 867983, 25895, 856291, 25278, </team_members_id><team_members_names><![CDATA[Mario Stojanović, Iva Škrinjar, Lucia Grenga, Jean ARMENGAUD, Alan  Parker, Isabela Drašković, Lucija Lulić Horvat, ]]></team_members_names><keywords_hr><![CDATA[adenovirus, vakcinacija, genska terapija, odgovor stanice na infekciju, adenoviralni vektor, integrin, prijenos signala]]></keywords_hr><keywords_en><![CDATA[adenovirus, vaccination, gene therapy, cell host response to infection, adenovirus vector, integrin, cell signalling]]></keywords_en><summary_hr><![CDATA[Vektori koji se temelje na adenovirusu (AdV) trenutno su vodeći vektori u kliničkim ispitivanjima genske terapije, i to poglavito za liječenje raka i cijepljenje. Nisko seroprevalentni adenovirus čovjeka tipa 26 (HAdV-D26) pojavio se kao obećavajući kandidat za razvoj vektora cjepiva, a nedavno su cjepiva protiv Ebole i COVID-19 temeljena na HAdV-D26 odobrena za upotrebu od strane Europske unije. Iako je imunogenost HAdV-D26 in vivo prilično dobro opisana, još uvijek postoji niz otvorenih pitanja u vezi s osnovnom biologijom HAdV-D26. Na temelju naših prethodnih rezultata, odnosno činjenice da HAdV-D26 ko-lokalizira s avß3 integrinom te kada koristi avß3 integrin kao receptor, ulazi u stanice kroz kaveole, kao i preliminarnog različitog obrasca fosforilacije tirozina nakon infekcije s HAdV-D26 uočenog između stanica koje se razlikuju po ekspresiji avß3 integrina, pretpostavljamo da HAdV-D26, zbog vezanja na avß3 integrin i uključivanja u različite puteve ulaska u stanicu, izaziva drugačiji profil odgovora stanice domaćina. Budući da odgovor stanice domaćina izazvan vektorom AdV ograničava i utječe na performanse samog vektora, integrativne studije koje procjenjuju odgovor domaćina nakon infekcije HAdV-D26 vrlo su opravdane. Stoga je sveukupni cilj AdenoHost-a riješiti jasan jaz u poznavanju odgovora stanice domaćina potaknutog HAdV-D26 infekcijom epitelnih stanica u kontekstu upotrebe avß3 integrina kao HAdV-D26 receptora. Navedeno će se postići transkriptomskim, proteomskim i fosfoproteomskim profiliranjem kontrolnih i HAdV-D26 inficiranih epitelnih stanica s povećanom ekspresijom integrina avß3. Očekujemo da ćemo dobiti sveobuhvatnu integrativnu analizu biološki značajnih promjena u HAdV-D26 inficiranim epitelnim stanicama i detaljno razumijevanje HAdV-D26 potaknutog prijenosa signala domaćina nakon korištenja avß3 integrina. Ovo novo znanje bit će iznimno korisno za daljnje poboljšanje vektora temeljenih na HAdV-D26, ali i za virologiju općenito.]]></summary_hr><summary_en><![CDATA[Adenovirus (AdV) based vectors are currently leading vectors used in gene therapy clinical trials, namely cancer treatment and vaccination. Low seroprevalent human adenovirus type 26 (HAdV-D26) emerged as a candidate for vaccine vector development and very recently HAdV-D26 based vaccines against Ebola and COVID-19 received marketing authorization from European Union. While HAdV-D26 immunogenicity in vivo is rather well described questions regarding basic biology of HAdV-D26 are still opened. Based on our previous data, namely the fact that HAdV-D26 co-localizes with avß3 integrin and when uses avß3 integrin as a receptor it enters the cells through caveolae, as well as preliminary different pattern of tyrosine phosphorylation observed between cells differing in avß3 integrin expression infected with HAdV-D26, we assume that HAdV-D26, due to binding to avß3 integrin and engaging in different cell entry pathway induces different profile of host response. Since host signalling and response induced by AdV vector limit and influence performance of vector itself, integrative studies assessing the host response following HAdV-D26 infection are highly warranted. Thus, the overall goal of AdenoHost is to address clear gap in the regulatory landscape of host signalling induced by HAdV-D26 infection of epithelial cells in the context of the avß3 integrin usage as HAdV-D26 receptor. This will be achieved through transcriptomic, proteomic and phosphoproteomic profiling of mock and HAdV-D26 infected epithelial cells with avß3 integrin increased expression. We expect to obtain comprehensive integrative analysis of biologically significant changes in HAdV-D26 infected epithelial cells and detailed understanding of HAdV-D26 induced host signalling after engaging avß3 integrin, new knowledge that will be valuable for further improvement of HAdV-D26-based vectors for gene transfer and vaccination, and virology in general.]]></summary_en></project><project>
<id>17776</id><title_hr><![CDATA[Višemjesni supramolekulski gosti temeljeni na proširenom diamantanu]]></title_hr><title_en><![CDATA[Multitopic supramolecular guests based on extended diamantane]]></title_en><user_id>2988</user_id><user_firstLast_name>Marina Šekutor</user_firstLast_name><svouser_id>870483</svouser_id><svouser_firstLast_name>Robert Vicha</svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-9623</code><acronim><![CDATA[MultiDia]]></acronim><duration>05.12.2025 - 04.12.2028</duration><status>U tijeku</status><financ_value>199.870,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>3215, 3336, 2992, </team_members_id><team_members_names><![CDATA[Marija Alešković, Margareta  Sohora, Tatjana Šumanovac, ]]></team_members_names><keywords_hr><![CDATA[sustavi domaćin-gost, supramolekulske strukture, diamantan, višemjesni gosti, pseudorotaksani]]></keywords_hr><keywords_en><![CDATA[host-guest systems, supramolecular structure, diamantane, multitopic guests, pseudorotaxanes]]></keywords_en><summary_hr><![CDATA[Diamonijevi diamantanski gosti pokazuju do danas najviše poznate afinitete za komplekse domaćin-gost 1:1. Međutim, supramolekulska kemija naprednih analoga ostaje nedovoljno istražena. Višemjesni gosti, sastavljeni od veznih motiva koji pokazuju izrazitu selektivnost prema različitim domaćinima, ključne su komponente molekularnih uređaja, kao što su katalizatori, senzori, sustavi za isporuku lijekova i memorijske jedinice. Naši preliminarni rezultati s ciklodekstrinima (CD) i kukurbit[n]urilima (CB) pokazuju da diamantanski kavez proširen krutim ugljikovodičnim dijelovima (etilen glikol dimetil eter, EDM) može stvarati vezna mjesta prilagođena za parove ili skupove od tri čvrsto zbijena domaćina. Naš cilj je pripremiti modelne goste na temelju EDM-a u svrhu sustavnog ispitivanja njihove sposobnosti vezivanja, odnosno broja, vrste i međusobne orijentacije CB i CD jedinica. Nadalje, sintetizirat ćemo goste koji se sastoje od EDM-a i drugih veznih mjesta visokog afiniteta kako bismo razjasnili može li se drugim makrociklima mijenjati ili utjecati na načine vezivanja EDM-a. Stjecanje ovog temeljnog znanja imat će značajan utjecaj na dizajn supramolekulskih uređaja.]]></summary_hr><summary_en><![CDATA[Diammonium diamantane-based guests demonstrate the highest affinities reported to date for 1:1 host-guest complexes. However, supramolecular chemistry of advanced analogs remains underexplored. Multitopic guests, composed of binding motifs exhibiting distinct selectivity towards different hosts, are pivotal components of molecular devices such as catalysts, sensors, drug delivery systems, and memory units. Our preliminary results with cyclodextrins (CD) and cucurbit[n]urils (CB) indicate that diamantane cage extended with rigid hydrocarbon moieties (ethylene glycol dimethyl ether, EDM) can form binding sites tailored for pairs or triplets of tightly packed hosts. Thus, we aim to prepare model guests based on EDM to thoroughly examine their binding abilities, i.e., the number, type, and mutual orientations of CB and CD units. Further, we will synthesize guests comprising EDM and other high-affinity binding sites to elucidate whether the binding modes at EDM can be affected, altered, or switched by other macrocycles. Acquisition of this fundamental knowledge will profoundly impact the design of supramolecular devices.]]></summary_en></project><project>
<id>17783</id><title_hr><![CDATA[Dizajn i sinteza višekomponentnih krutina uporabom koordinacijskih spojeva i halogenskih veza]]></title_hr><title_en><![CDATA[Design and synthesis of multicomponent solids using metal coordination compounds and halogen bonds]]></title_en><user_id>356</user_id><user_firstLast_name>Dominik Cinčić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-6539</code><acronim><![CDATA[HaloMetal]]></acronim><duration>15.12.2025 - 14.12.2028</duration><status>U tijeku</status><financ_value>199.950,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>12541, 4525, 29303, 858398, 24307, 13224, 864960, 17739, 310, </team_members_id><team_members_names><![CDATA[Vinko Nemec, Nenad Judaš, Nea Baus Topić, Lidija Posavec, Nikola Bedeković, Tomislav Friscic, Mihails Arhangelskis, Mladen Borovina, Vladimir Stilinović, ]]></team_members_names><keywords_hr><![CDATA[Halogenska veza, metalo-organski materijali, kokristali, supramolekulska kemija, mehanokemija]]></keywords_hr><keywords_en><![CDATA[Halogen bond, metal-organic materials, cocrystals, supramolecular chemistry, mechanosynthesis]]></keywords_en><summary_hr><![CDATA[Većina do danas pripravljenih višekomponentnih materijala povezanih halogenskom vezom su kokristali u kojima su i akceptori i donori halogenske veze organske molekule, dok su metaloorganski kompleksi znatno slabije istraženi kao građevni blokovi. Unatoč tome, sve je veće zanimanje za kokristale koordinacijskih spojeva metala iz razloga što vrste koje sadrže metale mogu imati interesantna i potencijalno primjenjiva svojstva. Ovaj projekt će u nastavku naših prethodnih istraživanja kristalnog inženjerstva kokristala povezanih halogenskom vezom, proširiti primjenu halogenske veze u kristalnom inženjerstvu višekomponentnih materijala korištenjem različitih metaloorganskih akceptora i donora, u rasponu od diskretnih mononuklearnih ili polinuklearih kompleksa metala do 1D ili 2D koordinacijskih polimera. Ciljevi predloženog projekta su: i) postaviti strategije za korištenje novih motiva halogenske veze s rjeđe istraživanim metaloorganskim akceptorima halogenske veze, ii) utvrditi općenite strategije za pouzdanu sintezu kokristala koordinacijskih polimera metala (1D i 2D), iii) postaviti opću strategiju za dizajn krutina s perhalogeniranim metaloorganskim donorima halogenske veze, iv) razraditi supramolekulsku hijerarhiju međumolekulskih interakcija u ionskim metaloorganskim kristalima povezanim halogenskim vezama, v) razviti opću strategiju za dizajn ternarnih kristala s halogenskom vezom, i vi) istražiti utjecaj kokristalizacije (prisutnosti donora halogenske veze i sveukupne supramolekulske strukture) na magnetska i električna svojstva koordinacijskih spojeva. Očekivani doprinos projekta je fundamentalnog karaktera u područjima kristalnog inženjerstva, te eksperimentalne i teorijske supramolekulske kemije. Važnost je u otvaranju novih mogućnosti primjene halogenskih veza u dizajnu kokristala i istraživanju novih akceptora i donora halogenske veze za specifične primjene u kristalnom inženjerstvu. ]]></summary_hr><summary_en><![CDATA[A vast majority of halogen-bonded multicomponent materials prepared to date have been cocrystals where organic molecules are both halogen bond acceptors and donors, while metal-organic complexes as building blocks have been much less explored. However, interest in cocrystals incorporating metal coordination compounds is increasing, given that metal-containing species can exhibit captivating and potentially applicable properties. As a continuation of our previous work in crystal engineering of halogen-bonded cocrystals, this project will expand halogen bonding as a tool in the crystal engineering of multi-component materials through involvement with a wide range of metal-organic acceptor and donor types, from discrete mononuclear or polynuclear metal complexes to 1D or 2D coordination polymers. The goals of this project are: i) to establish strategies for the utilization of new halogen bonding motifs with seldom studied metal-organic halogen bond acceptors,  ii) to establish general strategies for the reliable construction of cocrystals based on metal coordination polymers (1D and 2D), iii) to establish general strategies for the design of solids containing perhalogenated metal-organic halogen bond donors, iv) to elucidate the supramolecular hierarchy of intermolecular interactions in ionic metal-organic crystals based on halogen bonds, v) to develop a general strategy for designing ternary halogen-bonded crystals, and vi) to investigate the influence of cocrystallization (the presence of halogen bond donors and the overall supramolecular structure) on magnetic and electric properties of coordination compounds. The expected project contribution is primarily fundamental for crystal engineering and both experimental and theoretical supramolecular chemistry. The importance lies in opening new opportunities for using halogen bonds in the design of cocrystals and investigating new halogen-bonding acceptors and donors for specific crystal engineering applications.]]></summary_en></project><project>
<id>17784</id><title_hr><![CDATA[Napredni autonomni viličari u nestrukturiranim skladištima]]></title_hr><title_en><![CDATA[Advanced autonomous forklifts in unstructured warehouses]]></title_en><user_id>24177</user_id><user_firstLast_name>Goran Vasiljević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2025-02</proposal_call><code>UIP-2025-02-6833</code><acronim><![CDATA[NAViNeS]]></acronim><duration>01.04.2026 - 31.03.2031</duration><status>U tijeku</status><financ_value>298.920,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, Računarstvo, Strojarstvo, Tehnologija prometa i transport, </scie_field_hr><scie_field_en>Electrical engineering, Computer sciences, Mechnical engineering, Transport technology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>24184, </team_members_id><team_members_names><![CDATA[Tamara Petrović, ]]></team_members_names><keywords_hr><![CDATA[robotika,viličari,skadišta,autonomni,koordinacija]]></keywords_hr><keywords_en><![CDATA[robotics,forklifts,warehouses,autonomous,coordination]]></keywords_en><summary_hr><![CDATA[Cilj projekta je provedba istraživanja o upravljanju novom vrstom autonomnih viličara, koji su sposobni manipulirati objektima u nestrukturiranim skladištima i industrijskim okruženjima. Postojeći autonomni viličari bit će nadograđeni s pomičnom robotskom rukom. Takav sustav zvat će se AVRR i njegovo upravljanje predstavljat će središnji fokus istraživanja. AVRR će omogućiti utovar različitih vrsta objekata na vilice i tako uvelike proširiti mogućnosti trenutačno dostupnih autonomnih viličara. Tijekom projekta planira se istraživanje novih metoda planiranja prikupljanja objekata za AVRR, uzimajući u obzir mogućnost AVRR-a da tijekom rada premjesti određene prepreke. Također, razvit će se nove metode upravljanja koje će omogućiti koordinaciju između gibanja vilica, robotske ruke i pogonskog sustava viličara za postizanje utovara i transport teških i velikih predmeta. Dodatno, provest će se istraživanje koordiniranog gibanja više AVRR-ova kako bi prenijeli dodatne klase objekata koje nije moguće prenijeti jednim AVRR-om.]]></summary_hr><summary_en><![CDATA[The goal of the project is to research the control of a new type of autonomous forklift capable of manipulating objects in unstructured warehouses and industrial environments. Existing autonomous forklifts will be upgraded with a moving robotic arm. Such a system will be called AVRR and its control will be the focus of research. AVRR will enable loading different types of objects onto the forks, significantly expanding the capabilities of currently available autonomous forklifts. During the project, it is planned to investigate new methods for planning the collection of objects with the AVRR, taking into account the AVRR&#39;s ability to reallocate certain obstacles during operation. New control methods will also be developed to enable coordination between the movements of the forks, the robot arm and the forklift drive to enable the loading and transportation of heavy and large objects. Coordinated movement of multiple AVRRs will also be explored to transport additional classes of objects that cannot be transported by a single AVRR.]]></summary_en></project><project>
<id>17787</id><title_hr><![CDATA[Dekodiranje evolucije i recidiva osteosarkoma prostornom analizom transkriptoma ]]></title_hr><title_en><![CDATA[Decoding osteosarcoma evolution and recurrence with spatial transcriptome analysis]]></title_en><user_id>1188</user_id><user_firstLast_name>Rosa Karlić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-5581</code><acronim><![CDATA[OSTEO-ATLAS]]></acronim><duration>15.12.2025 - 14.12.2028</duration><status>U tijeku</status><financ_value>199.985,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>3273, 858372, 4867, 25311, 868207, 23958, </team_members_id><team_members_names><![CDATA[Inga Urlić, Paula Štancl, Marija Milavić, Sunčana Sikirić, Aleksandra Bonevski, Marijana Šimić Jovičić, ]]></team_members_names><keywords_hr><![CDATA[osteosarkom, prostorna transkriptomika, mutacijski potpisi, genomika, bioinformatika, evolucija tumora, rezistencija na terapiju]]></keywords_hr><keywords_en><![CDATA[osteosarcoma, spatial transcriptomics, mutational signatures, genomics, bioinformatics, cancer evolution, therapy resistance]]></keywords_en><summary_hr><![CDATA[Osteosarkom, mezenhimski tumor s incidencijom od 4–5 slučajeva na milijun godišnje, prvenstveno pogađa adolescente i mlade odrasle. Dok je kemoterapija učinkovita za nemetastatske slučajeve, metastatska bolest ima nisku stopu preživljavanja od 20%. Ciljane terapije su ograničene zbog različitih temeljnih mutacija i visoke heterogenosti tumora, uzrokovane evolucijom različitih tumorskih klonova. Razumijevanje molekularnih mehanizama inicijacije i progresije tumora ključno je za poboljšanje liječenja, ali genomskih podataka o osteosarkomu, posebno na razini jedne stanice, nedostaje zbog njegove rijetkosti.Naš cilj je primijeniti novi pristup za karakterizaciju genomskih profila uzoraka osteosarkoma i istraživanje evolucije tumora pod selektivnim pritiskom terapije. Procjenom uzoraka prikupljenih tijekom 20 godina, odabrat ćemo pacijente na temelju povijesti bolesti, liječenja i dostupnosti arhivskih uzoraka u trenutku dijagnoze, resekcije i recidiva. Sekvencirat ćemo do 20 genoma osteosarkoma prilikom dijagnoze kako bismo identificirali gene pokretače i mutacijske potpise uključene u karcinogenezu, istovremeno provodeći molekularnu potklasifikaciju. Detaljno ćemo karakterizirati uzorke iz različitih faza progresije tumora kod 4–6 reprezentativnih pacijenata s osteosarkomom iz različitih podtipova. Cjelogenomsko sekvenciranje bit će korišteno za praćenje klonalne ekspanzije povezane s otpornošću na liječenje i recidivom, dok će analiza prostorne transkriptomike omogućiti razlučivanje pojedinih populacija stanica i njihovih različitih transkriptomskih profila.Ove prostorne i vremenske analize razotkrit će heterogenost i evoluciju tumora, dinamiku neoantigena i promjene u mikrookruženju. Istražiti ćemo i mehanizme otpornosti na lijekove i prilagodbe izazvane terapijom, pružajući okvir za unapređenje precizne onkologije i poboljšanje tretmana. Ovo će biti prvi skup podataka te vrste za osteosarkom, nudeći jedinstvene uvide u njegovu molekularnu sliku i terapijske izazove.]]></summary_hr><summary_en><![CDATA[Osteosarcoma, a mesenchymal tumor with an incidence of 4–5 cases per million annually, primarily affects adolescents and young adults. While chemotherapy is effective for non-metastatic cases, metastatic disease has a low 20% survival rate. Targeted therapy approaches are limited due to different underlying mutations and high heterogeneity of tumors, caused by the evolution of distinct tumor clones. Understanding molecular mechanisms of tumor initiation and progression is key to improving treatment, but osteosarcoma genomic data, especially at the single-cell level, remains scarce due to its rarity.Our objective is to employ a novel approach to characterize the genomic profiles of osteosarcoma samples and investigate tumor evolution under the selective pressure of therapy. Evaluating samples collected over 20 years, we will select patients based on medical history, treatment, and availability of archived samples at the time of diagnosis, resection, and relapse. We will sequence up to 20 osteosarcoma genomes at diagnosis to identify driver genes and mutational signatures involved in carcinogenesis, while also performing molecular subtyping. We will characterize in detail samples from various tumor progression stages in 4–6 representative osteosarcoma patients across different subtypes. Whole-genome sequencing will be used to track clonal expansion linked to treatment resistance and relapse, while spatial transcriptome analysis will distinguish different cell populations and their distinct transcriptome profiles. These spatial and temporal analyses will uncover tumor heterogeneity and evolution, neoantigen dynamics and microenvironmental shifts. We will also investigate drug resistance mechanisms and therapy-induced adaptations, providing a framework to advance precision oncology and improve treatments. This will be the first dataset of its kind for osteosarcoma, offering unprecedented insights into its molecular landscape and therapeutic challenges.]]></summary_en></project><project>
<id>17788</id><title_hr><![CDATA[Croatia-Cyprus Excellence Hub on Eco-Innovative Technologies for Healthy and Productive Seas, WP2 - R&I strategy, action and investment plans]]></title_hr><title_en><![CDATA[]]></title_en><user_id>24177</user_id><user_firstLast_name>Goran Vasiljević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-6480</code><acronim><![CDATA[]]></acronim><duration>12.11.2025 - 11.11.2031</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>872925</team_members_id><team_members_names><![CDATA[ Doktorand: Marin Maletić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>17789</id><title_hr><![CDATA[Dinamički sustavi i reakcijsko kinetičke mreže ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1391</user_id><user_firstLast_name>Vesna Županović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-7639</code><acronim><![CDATA[]]></acronim><duration>10.11.2025 - 09.11.2031</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>872919</team_members_id><team_members_names><![CDATA[ Doktorand: Noah Marko Mesić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>17793</id><title_hr><![CDATA[Kvantni aspekti gravitacije]]></title_hr><title_en><![CDATA[Quantum aspects of gravity]]></title_en><user_id>2750</user_id><user_firstLast_name>Tajron Jurić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-8625</code><acronim><![CDATA[QAG]]></acronim><duration>08.12.2025 - 07.12.2028</duration><status>U tijeku</status><financ_value>135.620,16 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>1153, 865273, 866805, 470, 3371, 866806, 870214, 870200, </team_members_id><team_members_names><![CDATA[Anđelo Samsarov, Nikola Herceg, Filip Pozar Požar, Hrvoje Nikolić, Ivica Smolić, Ana Bokulić, Aleksandr Pinzul, Carolina Gregory, ]]></team_members_names><keywords_hr><![CDATA[kvantna gravitacija, nekomutativna geometrija, gravitacijski valovi, kvazinormalni modovi, singulariteti]]></keywords_hr><keywords_en><![CDATA[quantum gravity, noncommutative geometry, gravity waves, quasinormal modes, singularities]]></keywords_en><summary_hr><![CDATA[Ovaj projekt istražuje modele kvantne gravitacije, fokusirajući se na spektralna svojstva crnih rupa, uključujući kvazinormalne modove (QNM), i prirodu gravitacijskih singulariteta. Potaknuti nedavnim otkrićima u astrofizici, poput detekcije Event Horizon Telescope i LIGO, istražujemo kvantne modifikacije opće relativnosti unutar fizike crnih rupa, uključujući metričke perturbacije i gravitacijske valove. Naši ciljevi uključuju razvoj i analizu kvantnih modela korištenjem nekomutativne diferencijalne geometrije za rješavanje jednadžbi gibanja za metričke perturbacije na fiksnoj Schwarzschildovoj, Kerrovoj i sporo rotirajućoj Kerrovoj pozadini. Proučavat ćemo QNM spektre poluanalitičkim i numeričkim metodama, testirati narušenje izospektralnosti i ispitati potencijalno &#39;&#39;razmazivanje&#39;&#39; klasičnih singulariteta kroz kvantno mehaničke probe. Metodološki pristup uključuje algebru infinitezimalnih difeomorfizama i Hopfove algebre za konstrukciju deformiranog Leibnizova pravila. Nadalje, projekt će koristiti inovativni okvir temeljen na nekomutativnoj diferencijalnoj geometriji, nadogradnjom utvrđenih metodologija u teorijskoj fizici i poticanjem međunarodne suradnje.]]></summary_hr><summary_en><![CDATA[This project explores quantum gravity models, focusing on the spectral properties of black holes, including quasinormal modes (QNMs), and the nature of gravitational singularities. Motivated by recent breakthroughs in astrophysics, such as the Event Horizon Telescope and LIGO detections, we investigate quantum modifications to general relativity within black hole physics, including metric perturbations and gravitational waves. Our objectives include developing and analyzing quantum models using noncommutative differential geometry to address gravitational perturbations of Schwarzschild, Kerr and slowly rotating Kerr black holes, revealing unique spectral features. We will study QNM spectra via semi-analytical and numerical methods, testing for the presence of isospectrality violations, and examine the potential &#39;&#39;smearing out&#39;&#39; of classical singularities through quantum mechanical probes. The methodological approach incorporates the algebra of infinitesimal diffeomorphisms and Hopf algebras to construct a deformed Leibniz rule. Furthermore, the project will employ an innovative framework based on noncommutative differential geometry, building on established methodologies in theoretical physics and fostering international collaboration.]]></summary_en></project><project>
<id>17801</id><title_hr><![CDATA[Topološki, geometrijski i kombinatorni aspekti dinamike u ravnini]]></title_hr><title_en><![CDATA[Topological, Geometrical, and Combinatorial aspects of Planar Dynamics]]></title_en><user_id>17706</user_id><user_firstLast_name>Ana Anušić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2025-02</proposal_call><code>UIP-2025-02-4309</code><acronim><![CDATA[ToGeCoP]]></acronim><duration>19.02.2026 - 18.02.2031</duration><status>U tijeku</status><financ_value>293.855,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>20035, </team_members_id><team_members_names><![CDATA[Kristijan Kilassa Kvaternik, ]]></team_members_names><keywords_hr><![CDATA[atraktor, inverzni limes, točka nehomogenosti, dendrit, smještenje u ravninu, dostupna točka, svojstvo fiksne točke, komutirajuća preslikavanja]]></keywords_hr><keywords_en><![CDATA[attractor, inverse limit, folding point, dendrite, planar embedding, accessible point, fixed point property, commuting maps]]></keywords_en><summary_hr><![CDATA[U ovom istraživačkom projektu provest ćemo detaljnu studiju različitih aspekata planarne dinamike. Naš prvi fokus bit će topološka struktura poznatih čudnih planarnih atraktora, poput onih koji se javljaju u Hénonovoj i Lozijevoj familiji planarnih homeomorfizama. Nedavna istraživanja sugeriraju da se mnogi od tih atraktora mogu modelirati pomoću dendrita, a pretpostavlja se da bi i jednostavnije strukture, poput stabala, mogle služiti kao učinkoviti modeli. Cilj nam je razviti analitičke alate za bolje razumijevanje tih modela, nadovezujući se na istraživanja članova tima K. Kilasse Kvaternika i P. Kucharskog. Daljnja proširenja metoda koje su razvili A. Anušić i J. Činč omogućit će detaljno proučavanje lokalnih (točke nehomogenosti, krajnje točke, grananja) i globalnih (kompozanti, struktura primarnih krajeva) topoloških svojstava čudnih planarnih atraktora.Drugi fokus našeg istraživanja temelji se na našim nedavnim rezultatima o planarnim smještenjima stablastih kontinuuma, za koje vjerujemo da bi mogli pružiti vrijedne uvide u problem svojstva fiksne točke u ravnini, koji je R. H. Bing opisao kao &#39;&#39;najvažniji problem u planarnoj geometriji&#39;&#39;. Planarnost stablastih kontinuuma i dalje je slabo shvaćena, što naglašava potrebu za razvojem novih alata u ovom području. Nedavno smo, u suradnji s A. Ammerlaan i L. Hoehnom, dokazali da su stablasti kontinuumi dobiveni dodavanjem luka u bilo koju točku lančastog kontinuuma planarni, čime smo riješili problem koji je bio otvoren više od 50 godina. Sada želimo generalizirati te tehnike kako bismo stekli dublji uvid u planarnost stablastih kontinuuma.Jedan od ključnih ciljeva ovog projekta jest uspostava nove istraživačke grupe i jačanje njezine međunarodne prisutnosti kroz suradnju s istraživačima iz Europe, SAD-a, Kanade i Brazila. Tijekom četiri godine planiramo zaposliti jednog ili dva poslijedoktoranda te očekujemo barem jednu uspješno obranjenu doktorsku disertaciju kao izravan rezultat ovog projekta.]]></summary_hr><summary_en><![CDATA[In the proposed research project, we will conduct a detailed study of various aspects of planar dynamics. Our first focus is on the topological structure of famous strange planar attractors, such as those arising in the Hénon and Lozi families of planar homeomorphisms. Recent studies suggest that many of these attractors can be modeled using dendrites, and it is suspected that simpler structures, such as trees, may also serve as effective models. We aim to develop analytical tools to better understand these models, building on the research of team members K. Kilassa Kvaternik and P. Kucharski. Further extensions of methods developed by A. Anušić and J. Činč will enable a detailed study of both local (inhomogeneity points, endpoints, branching points) and global (composants, prime end structure) topological properties of strange planar attractors.The second focus of our research is building on our recent results on planar embeddings of tree-like continua, which we believe could provide valuable insights into the planar fixed point property problem, famously described by R. H. Bing as &#39;&#39;the most important problem in planar geometry&#39;&#39;.  The planarity of tree-like continua remains poorly understood, highlighting the need for new tools in the area. Recently, in collaboration with A. Ammerlaan and L. Hoehn, we proved that tree-like continua obtained by adding an arc at any point of an arc-like continuum are planar, resolving a 50-year-old open problem. We now aim to generalize these techniques to gain deeper insights into the planarity of tree-like continua.One of the key goals of this project is establishing a new research group and strengthening its international presence through collaborations with researchers from Europe, USA, Canada, and Brazil. Over four years, we plan to hire one or two postdoctoral researchers and anticipate at least one successfully defended PhD thesis as a direct outcome of this project.]]></summary_en></project><project>
<id>17803</id><title_hr><![CDATA[Pouzdanost i nesigurnosti brodskog sustava potpori odlučivanju za sigurnu i &#39;&#39;zeleniju&#39;&#39; plovidbu]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4179</user_id><user_firstLast_name>Duško Pavletić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-4803</code><acronim><![CDATA[REBUS]]></acronim><duration>20.11.2025 - 21.06.2030</duration><status>U tijeku</status><financ_value>55,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, </scie_field_hr><scie_field_en>Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Tehnički fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Engineering]]></institution_en><team_members_id>872939</team_members_id><team_members_names><![CDATA[ Doktorand: Ivana Čabrijan ]]></team_members_names><keywords_hr><![CDATA[brod, pomorstvenost, sustav potpori odlučivanju, emisija stakleničkih plinova, navigacija, sigurnost]]></keywords_hr><keywords_en><![CDATA[ship, seakeeping, decision support system, greenhause gases emissions, navigation, safety]]></keywords_en><summary_hr><![CDATA[Cilj istraživanja u okviru projekta Pouzdanost i nesigurnosti brodskog sustava potpori odlučivanju za sigurnu i &#39;&#39;zeleniju&#39;&#39; plovidbu (REBUS) je analiza pouzdanosti i nesigurnosti vezanih uz  sustav potpore odlučivanju (Decision Support System - DSS) kapetanima broda, kao i zapovjednicima stroja, a koji bi doprinio ”zelenijoj” i sigurnijoj plovidbi brodova. Projekt se nastavlja na tekući projekt Hrvatske zaklade za znanost, br. IP-2018-01-3739 Sustav potpore odlučivanju za zeleniju i sigurniju plovidbu brodova  (DESSERT) tijekom kojeg se razvija sustav potpore odlučivanja koji, osim ekonomskih (potrošnja), uzima u obzir ekološke aspekte i aspekte sigurnosti tijekom navigacije. Istraživanja vezana uz analizu DSS-a odvijat će se u dva osnovna smjera: analiza nesigurnosti i procjena pouzdanosti sustava potpore odlučivanju za energetski učinkovitija plovidbu uz smanjenje emisije stakleničkih plinova; analiza nesigurnosti i procjena pouzdanosti sustava za pravovremenu reakciju u slučaju naplavljivanja broda.Mjerenja navigacijskih i pogonskih parametara broda koristeći više različitih mjernih sustava analizirat će se sa stanovišta definiranja nesigurnosti i procjene pouzdanosti  samih mjerenja. Velika baza mjerenih podataka, kao i numerički dobivenih podataka korištenjem računarske dinamike fruida (CFD)  te podataka dobivenih na simulatoru navigacije koristit će se za analizu pouzdanosti numeričkog modela za procjenu smjerovnog spektra valova iz mjerenih njihanja broda, kao i za validaciju metodologije procjene brzine broda, potrošnje goriva i emisije stakleničkih plinova. Cilj je sustavno analizirati sustav potpore odlučivanju na brodu uzimajući u obzir projektantsku, strojarsku i pomorsku ekspertizu u cilju stvaranja sigurnog i ekološki učinkovitog ili &#39;&#39;zelenijeg&#39;&#39; broda i plovidbe. Projektni tim sastoji se od znanstvenika koji su stručnjaci u brodogradnji, strojarstvu,  pomorskom inženjerstvu i računarstvu koji omogućuju multidisciplinarno rješavanje ovog problema.]]></summary_hr><summary_en><![CDATA[The goal of the research in a frame of project REliaBility and Uncertainty of Ship decision support system for safe and greener navigation – REBUS is the analysis of reliability and uncertainties ralarted to Decision Support System (DSS) is planned for ship captains as well as machine commanders, which would contribute to &#39;&#39;greener&#39;&#39; and safer navigation of ships.The project continues the ongoing Croatian Science Foundation project, No. IP-2018-01-3739 DEcision Support System for green and safe ship RouTing (DESSERT), which is developing a decision support system that takes into account not only economic but also environmental and safety aspects of navigation. Research related to DSS analysis will proceed in two basic directions: Uncertainty analysis and reliability assessment of the decision support system for more energy efficient navigation while reducing greenhouse gas emissions; Uncertainty analysis and reliability assessment of the system for timely response in case of a flooding.Measurements of navigation and operational parameters of the ship using various measurement systems will be analyzed from the point of view of defining uncertainty and evaluating the reliability of the measurements themselves. A large database of measured data, data obtained by CFD and on navigation simulator will be used to analyze the reliability of a numerical model for estimating the directional spectrum of waves from measured ship motions and to validate the methodology for estimating ship speed, fuel consumption and GHG emissions.The goal is to systematically analyze the shipboard decision support system, taking into account design, engineering, and maritime expertise, to create a safer and more environmentally efficient or &#39;&#39;greener&#39;&#39; ship and navigation. The project team consists of scientists who are experts in naval architecture, mechanical engineering, marine engineering and computer science, which enables a multidisciplinary solution to this problem.]]></summary_en></project><project>
<id>17805</id><title_hr><![CDATA[Chemical and pressure engineering of cobaltite-based perovskites]]></title_hr><title_en><![CDATA[]]></title_en><user_id>13002</user_id><user_firstLast_name>Martina Vrankić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-1254</code><acronim><![CDATA[CePrECiPe]]></acronim><duration>29.12.2025 - 28.12.2030</duration><status>U tijeku</status><financ_value>60,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>872992</team_members_id><team_members_names><![CDATA[ Doktorand: Dora Balen ]]></team_members_names><keywords_hr><![CDATA[kobaltovi perovskiti; dopiranje, mehanokemija, kemijsko inženjerstvo, tlačno inženjerstvo, odnos struktura-svojstvo na visokom tlaku]]></keywords_hr><keywords_en><![CDATA[Cobaltite-based perovskites, doping, mechanochemistry, chemical engineering, pressure engineering, high pressure structure-property relationship]]></keywords_en><summary_hr><![CDATA[Kobaltni oksidi tipa perovskita atraktivni su spojevi za fotonaponske uređaje, katalizatore, termoelektrike, baterije, superkondenzatore i uređaje za pohranu. Jedinstvena kemijska, fizikalna i mehanička svojstva rezultat su prilagodljivosti njihove kristalne strukture, koja se može podesiti kemijskim inženjerstvom (npr. dopiranjem) i/ili post-sintetskim tretmanom pod visokim tlakom. Sinergija saznanja o sintezi ovih materijala, te njihovog odgovora na kompresiju/dekompresiju, omogućiti će razumijevanje sprege struktura-svojstvo pri visokim tlakovima. Projektni prijedlog ima za cilj stjecanje komplementarnog znanja o odnosu putova sinteze perovskita na bazi kobalta (LaXCa1-XCoyM1-yO3-d (M = Ni, Co, Cr, Fe, x = 0.1-0.5; y = 0.1-1.0) i rasvjetljavanja njihovih fundamentalnih kristalografskih i fizikalno-kemijskih svojstava. Za dobivanje različitih morfologija i kemijskih struktura koristiti će se sol-gel, koprecipitacija i mehanokemija, dok će se kristalne strukture i fazne stabilnosti podešavati strategijom dopiranja. Proučiti će se utjecaj konvencionalnog sinteriranja, te taloženja u plazmi na transformacije kristalnih struktura, te njihove termoelektrične, elektrokatalitičke i kemokatalitičke funkcionalnosti. Pored kemijskog inženjerstva, hidrostatski tlak će se koristiti kao čisti alat za podešavanje struktura perovskita i njihovih funkcionalnosti, što može rezultirati nizom, egzotičnih svojstava: sužavanje energijskog procijepa, pojačanje intenziteta fotoluminiscencije, zadržavanje visokotlačne faze pri ambijentalnim uvjetima, metalizacija, amorfizacija i fazni prijelazi. Spektar in situ metoda pri visokom tlaku (rendgenska difrakcija u prahu, Ramanova i apsorpcijska spektroskopija te mjernja električnog otpora) do 50 GPa poboljšat će fundamentalno razumijevanje mehanizma koji leži u sprezi strukture i svojstava perovskita, a koja rasvjetljuju pozadinu iznimnih svojstava kao rezultat primjerene dopiranja i kompresije/dekompresije u području vrlo visokih  tlakova. ]]></summary_hr><summary_en><![CDATA[Cobalt oxides of the perovskite type are attractive materials for photovoltaics, catalysts, thermoelectrics, batteries, supercapacitors, and storage devices. Their unique chemical, physical, and mechanical properties are due to the remarkable tunability of their crystal structure, which can be adjusted through chemical syntheses and/or high-pressure post-synthesis treatments. The synergy of knowledge on perovskite syntheses under ambient and non-ambient conditions will allow us to understand and develop the basis for the creation of new perovskite structures with unprecedented functional properties. In particular, the proposal aims to gain knowledge about the relationship between the synthesis pathways of cobaltite-based perovskites, (LaXCa1-XCoyM1-yO3-d (M = Ni, Co, Cr, Fe, x = 0.1-0.5; y = 0.1-1.0)  and their crystallographic and physicochemical features. To obtain different morphologies, sol-gel, co-precipitation, and mechanochemical chemistry will be used, while crystal structures and phase stabilities will be tuned by doping strategy. The course of conventional sintering and plasma deposition on thermally-induced transformations in the crystal structures and phases of the perovskites and their specific thermoelectric, electrocatalytic, and chemocatalytic functionalities will be studied in detail. In addition to chemical engineering, hydrostatic pressure will be used as a clean tool to tune the structures of selected perovskites and their functionalities, leading to exotic features like bandgap narrowing, photoluminescence intensity enhancement, ambient-memorised retainability, metallization, amorphization, and phase transitions. Selection of in situ high-pressure experiments (powder X-ray diffraction, Raman and absorption spectroscopy, and electrical resistance studies (up to 50 GPa) will improve the understanding of the underlying physics and structure-property correlations of prepared perovskites by revealing new features and functionalities.]]></summary_en></project><project>
<id>17812</id><title_hr><![CDATA[Digitalni podatci, infrastrukture i razvoj]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1329</user_id><user_firstLast_name>Paško Bilić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-4530</code><acronim><![CDATA[DEVELOPER]]></acronim><duration>01.01.2026 - 01.01.2031</duration><status>U tijeku</status><financ_value>60,00 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Sociologija, </scie_field_hr><scie_field_en>Sociology, </scie_field_en><institution_hr><![CDATA[Institut za razvoj i međunarodne odnose]]></institution_hr><institution_en><![CDATA[Institute for Development and International Relations]]></institution_en><team_members_id>873020</team_members_id><team_members_names><![CDATA[ Doktorand: Nikolina Rajković ]]></team_members_names><keywords_hr><![CDATA[Digitalni podatci, infrastrukture, platforme, institucije, organizacije, svakodnevica, razvoj]]></keywords_hr><keywords_en><![CDATA[Digital data, infrastructures, platforms, institutions, organizations, everyday life, development]]></keywords_en><summary_hr><![CDATA[Digitalni podatci distribuirani s pomoću internetskih platformi, pametnih telefona i drugih naprava postali su izvor intenzivne komercijalizacije i razvoja javnih infrastruktura u razvijenim zemljama. Podatci su nužni za razvoj algoritama kojima se strojnim učenjem i obradom prirodnog jezika konstruira umjetna inteligencija, zamjenjuje spora ručna obrada podataka i pružaju novi analitički uvidi. S obzirom na to da sve više podataka postaje dostupno u digitalnim formatima, često se tvrdi da će podatci postati pokretač ekonomskog rasta i dobrobiti. Međutim, ekonomski i društveni razvoj nije izravna primjena računalnih metoda, nego složen proces koji ovisi o brojnim društvenim čimbenicima. Razumijevanje uloge podataka u društvu predmet je intenzivnih rasprava i istraživanja infrastruktura te kritičkih istraživanja podataka i platformi. Projektom DEVELOPER provest će se interdisciplinarna analiza iz perspektive društvenih znanosti. Istražit će se uloga podataka u društvu na razini institucija (zakona i tržišta), organizacija (privatnih i javnih) i svakodnevnog života građana. Pritom će se izbjegavati utopijska i distopijska razmišljanja o velikim podatcima kako bi se empirijski istražilo čimbenike koji unaprjeđuju ili sprječavaju razvoj podatkovnih infrastruktura i njihovu ulogu u stvaranju privatnog i javnog bogatstva. Primijenit će se eksplorativni, sekvencijalni idejni nacrt mješovitih metoda sa svrhom razumijevanja normi, vrijednosti, iskustava i praksa povezanih s digitalnim podatcima i podatkovnim infrastrukturama. Unaprijedit će se i poboljšati znanje u znanstvenoj zajednici o podatkovnim infrastrukturama u postsocijalističkim zemljama ekonomske periferije Europske unije. Empirijskim istraživanjima doprinijet će se daljnjem razvoju strateških planova Europske komisije i Nacionalne razvojne strategije kako bi se omogućila bolja regulacija, poboljšali organizacijski i radni uvjeti i građani uključili u digitalne usluge.]]></summary_hr><summary_en><![CDATA[Digital data circulated through internet platforms, smartphones, and other devices have become the source of intense commercial activity and public infrastructure advancement in developed countries. Data is an essential input for algorithms, enabling the construction of artificial intelligence with the help of machine learning and natural language processing while replacing manual, time-consuming data management and providing new analytical insights. As more digital data becomes available, it is often said to be the driver of economic growth and well-being. However, economic and social development is not a straightforward implementation of computational techniques but a process dependent on multiple social factors. Understanding the role of data in society has been the focus of intense debate in infrastructure studies, critical data studies and platform studies. The DEVELOPER project will provide an interdisciplinary social science analysis. It aims to examine the role of digital data in society at the level of institutions (law and markets), organisations (private and public), and the everyday life of citizens. We will move away from utopian or dystopian visions of (big) data and empirically explore factors that foster or hinder the development of data infrastructures, including their role in producing private and public wealth. The Project will follow an exploratory, sequential, mixed-methods research design to understand norms, values, experiences, and practices attributed to digital data and data infrastructures. It will advance knowledge in the scientific community and provide a better understanding of data infrastructures in the post-socialist economic periphery of the European Union. Assessments based on empirical research will further develop strategic plans outlined by the European Commission and the Croatian National Development Strategy, foster regulatory oversight, improve organisational and working conditions, and include citizens in digital services. ]]></summary_en></project><project>
<id>17817</id><title_hr><![CDATA[Peptidni adjuvanti: sinteza, strukturna karakterizacija i imunološka evaluacija]]></title_hr><title_en><![CDATA[The peptide adjuvants: synthesis, structural characterization and immunological evaluation]]></title_en><user_id>484</user_id><user_firstLast_name>Rosana Ribić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-5568</code><acronim><![CDATA[PASSI]]></acronim><duration>10.12.2025 - 09.12.2028</duration><status>U tijeku</status><financ_value>195.950,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište Sjever]]></institution_hr><institution_en><![CDATA[University North]]></institution_en><team_members_id>9862, 300, 3289, 861508, 12582, 26616, 485, 492, 866265, 23983, 5597, </team_members_id><team_members_names><![CDATA[Žiga Jakopin, Lidija Barišić, Ivo Dumić-Čule, Sonja Obranić, Tomislav Meštrović, Marijana Neuberg, Željka Car, Vesna Petrović Peroković, DANIJELA BENEŠ, Marija Paurević, Monika Kovačević, ]]></team_members_names><keywords_hr><![CDATA[imunostimulacija, desmuramil-peptidi, manoza, ferocen, NOD2 receptor, CLR receptori]]></keywords_hr><keywords_en><![CDATA[immunostimulation, desmuramyl peptides, mannose, ferrocene, NOD2 receptor, CLR receptors]]></keywords_en><summary_hr><![CDATA[Najmanji peptidoglikanski fragment s adjuvantskim djelovanjem jest muramil-dipeptid (MDP). Ljudski organizam prepoznaje MDP kao strukturu povezanu s patogenim organizmom što dovodi do stimulacije imunološkog odgovora, aktivacijom NOD2 receptora. Poboljšanje farmakoloških svojstava postiže se povećanjem lipofilnosti MDP te pripravom desmuramil-peptidnih (DMP) derivata. Dodatno pojačanje adjuvantskog djelovanja DMP može se postići uvođenjem manoze (Man) zbog mogućnosti specifičnog prepoznavanja od strane manoznih receptora eksprimiranih na imunološki kompetentnim stanicama. Predlaže se sinteza novih aromatskih, organometalnih i manoznih DMP koji će se detaljno strukturno okarakterizirati te će se biološki evaluirati. Ispitati će se (i) imunološki učinak racionalno dizajniranih aromatskih, organometalnih i manoziliranih derivata peptidnih adjuvanata u in vitro i in vivo modelima, (ii) aktivacija NOD2 i manoznih receptora (eksperimentalno i računalno), (iii) primjena lipofilnih Man-DMP konjugata kod priprave imunološki aktivnih lipidnih formulacija. Lipidne formulacije mogu dodatno modulirati imunološki odgovor te omogućiti ciljanu dostavu. Istraživanjem će se doprinijeti boljem razumijevanju odnosa strukture i aktivnosti peptidnih adjuvanata, njihovog mehanizma imunološkog djelovanja te potencijalnoj primjeni u obliku lipidnih formulacija. ]]></summary_hr><summary_en><![CDATA[Muramyl-dipeptide (MDP) represents the minimal peptidoglycan fragment exhibiting adjuvant activity. The human immune system recognizes MDP as a pathogen-associated molecular pattern (PAMP), triggering an immune response through activation of the NOD2 receptor. Enhancing the pharmacological properties of MDP is achieved by increasing its lipophilicity and synthesizing desmuramyl-peptide (DMP) derivatives. Furthermore, the adjuvant potency of DMP can be augmented by conjugation with mannose (Man), enabling specific recognition by mannose receptors expressed on immunocompetent cells. This study proposes the synthesis of novel aromatic, organometallic, and mannose-conjugated DMP derivatives, which will undergo comprehensive structural characterization and biological evaluation. The key research objectives include: (i) assessing the immunomodulatory effects of rationally designed aromatic, organometallic, and mannosylated peptide adjuvant derivatives in both in vitro and in vivo models,(ii) investigating the activation of NOD2 and mannose receptors through experimental and computational approaches, and (iii) exploring the potential of lipophilic Man-DMP conjugates for developing immunologically active lipid-based formulations. Lipid formulations offer an additional means of modulating immune responses while facilitating targeted delivery. The findings of this research will contribute to a deeper understanding of the structure-activity relationship of peptide-based adjuvants, elucidating their immune activation mechanisms and their potential application in lipid-based immunotherapeutic formulations.]]></summary_en></project><project>
<id>17820</id><title_hr><![CDATA[Na rubu pameti: FPGA i AI bazirani sustavi za vremenski kritične primjene ]]></title_hr><title_en><![CDATA[On the edge of reason: FPGA and AI based systems for time critical applications]]></title_en><user_id>7058</user_id><user_firstLast_name>Josip Musić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-9094</code><acronim><![CDATA[FPGAI - TIME]]></acronim><duration>10.12.2025 - 09.12.2028</duration><status>U tijeku</status><financ_value>199.562,50 eur</financ_value><scie_area_hr>Tehničke znanosti, Prirodne znanosti, </scie_area_hr><scie_area_en>Technological sciences, Natural sciences, </scie_area_en><scie_field_hr>Interdisciplinarne tehničke znanosti, Fizika, Elektrotehnika, Računarstvo, </scie_field_hr><scie_field_en>Interdisciplinary technological sciences, Physics, Electrical engineering, Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Fakultet elektrotehnike, strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Electrical Engineering, Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>868011, 867970, 19070, 27029, 868056, 6750, 21369, 865037, </team_members_id><team_members_names><![CDATA[Arijana Burazin Mišura, Vesna Pekić, Toni Šćulac, Ante Kristić, Ana Šćulac, Damir Lelas, Marina Prvan, Luka Palada, ]]></team_members_names><keywords_hr><![CDATA[FPGA, AI, ML, HEP, detektor čestica, UAV, klasifikacija, prilagodljivi sustavi]]></keywords_hr><keywords_en><![CDATA[FPGA, AI, ML, HEP, particle detectors, UAV, classification, adaptive systems]]></keywords_en><summary_hr><![CDATA[Umjetna inteligencija (AI) i strojno učenje (ML), posebno različite vrste neuronskih mreža, postali su transformativna snaga u modernom društvu. Neuronske mreže su revolucionirale modeliranje temeljeno na podacima i donošenje odluka u stvarnom vremenu. Međutim, potreba za postojanjem velike količine podataka (i njihova skladištenja i prijenosa) te računalne snage (koja troši veće količine energije) može u nekim situacijama biti ograničavajući faktor za primjenu AI. Stoga je primjena algoritama AI na uređajima na rubu (eng. edge devices) privukla značajnu pozornost posljednjih godina. Obrađujući podatke lokalno, uređaji na rubu mogu funkcionirati u stvarnom vremenu bez potrebe za komunikacijom s udaljenim poslužiteljima, što je bitno za vremenski kritične aplikacije kao što su izbjegavanje prepreka kod bespilotnih letjelica ili donošenja odluke o odbacivanju ili snimanju podataka na velikom hadronskom sudaraču (LHC) u CERN-u. Obje primjene se razmatraju u projektnoj prijavi kako bi se pokazala prilagodljivost razvijenih pristupa i algoritama.U projektnom prijedlogu se također analizira samointerakcija Higgsovih bozona kroz potpuno novi, do sada neistraženi kanal u kojem se Higgsovi bozoni raspadaju na dva W/Z bozona koristeći podatke prikupljene CMS detektorom. Proučavanja interakcija elementarnih čestica ne bi bila moguća bez aktivnog razvoja novih tehnologija za detekciju čestica. Dio ovog projekta je rad na razvoju programabilnih čipova za HGCAL detektor čiji početak rada je planiran 2029. godine. Novi detektor će imati nezavidan zadatak analize oko 8 tisuća milijardi sudara protona u sekundi i jedini način da se u takvim sudarima pronađu potencijalno zanimljivi događaji je uz pomoć takozvanog sustava okidača (eng. trigger). Stoga se u projektu razmatraju i razvijaju različite strategije razvoja i implementacije neuronskih mreža (posebno konvolucijskih neuronskih mreža koje su dominantno upotrebljavaju u primjena obrade slike) u FPGA uređajima.  ]]></summary_hr><summary_en><![CDATA[Artificial Intelligence (AI) and Machine Learning (ML), particularly various types of neural networks, have become a transformative force in modern society. Neural networks have revolutionized data-driven modeling and real-time decision-making. However, the need for large amounts of data (including its storage and transmission) and computational power (which consumes significant energy) can, in some cases, be a limiting factor in AI applications. Therefore, the deployment of AI algorithms on edge devices has garnered significant attention in recent years. By processing data locally, edge devices can operate in real-time without requiring communication with remote servers, which is crucial for time-sensitive applications such as obstacle avoidance in unmanned aerial vehicles or decision-making on whether to discard or record data in the Large Hadron Collider (LHC) at CERN. Both applications are considered in this project proposal to demonstrate the adaptability of the developed approaches and algorithms.The project proposal also analyzes the self-interaction of Higgs bosons through a completely new and previously unexplored channel, in which Higgs bosons decay into two W/Z bosons using data collected by the CMS detector. The study of elementary particle interactions would not be possible without the active development of new technologies for particle detection. A key part of this project involves the development of programmable chips for the HGCAL detector, which is expected to begin operations in 2029. The new detector will face the daunting task of analyzing approximately 8 trillion proton collisions per second, and the only way to identify potentially interesting events within such collisions is through a trigger system. Thus, the project explores and develops various strategies for designing and implementing neural networks, particularly convolutional neural networks (CNNs), which are predominantly used in image-processing applications, on FPGA devices.]]></summary_en></project><project>
<id>17822</id><title_hr><![CDATA[Tjelesna pismenosti kod predadolescenata i mlađih adolescenata: Učinci ciljane intervencije na tjelesnu aktivnost, tjelesni fitnes i zdravstvene ishode]]></title_hr><title_en><![CDATA[Physical literacy in preadolescents and young adolescents: Effects of targeted intervention on physical activity, physical fitness, and health outcomes]]></title_en><user_id>27180</user_id><user_firstLast_name>Barbara Gilić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2025-02</proposal_call><code>UIP-2025-02-3974</code><acronim><![CDATA[PL&PAH]]></acronim><duration>19.02.2026 - 18.02.2031</duration><status>U tijeku</status><financ_value>229.520,00 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Kineziologija, Edukacijsko-rehabilitacijske znanosti, Interdisciplinarne društvene znanosti, </scie_field_hr><scie_field_en>Kinesiology, Physical education and rehabilitation sciences, Interdisciplinary social sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Kineziološki fakultet]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Kinesiology]]></institution_en><team_members_id>861493, 867026, 861492, </team_members_id><team_members_names><![CDATA[Mirela Šunda, Marijana Geets-Kesić Geets-Kesić, Petra Rajković Vuletić, ]]></team_members_names><keywords_hr><![CDATA[tjelesna i zdravstvena kultura, rana školska dob, plan i program nastave, tjelesna aktivnost, tjelesni fitnes, intervencijska studija]]></keywords_hr><keywords_en><![CDATA[physical education, early school age, teaching plan and program, physical activity, physical fitness, intervention study]]></keywords_en><summary_hr><![CDATA[Tjelesna pismenost (TP) koncept je koji može poboljšati iskustva u nastavi tjelesne i zdravstvene kulture (TZK) i potaknuti sudjelovanje pojedinca u tjelesnoj aktivnosti (TA). TP je povezana sa poboljšanim tjelesnim fitnesom (TF), zdravstvenom pismenošću i zdravstvenim statusom. Prethodna istraživanja dokazala su da djeca imaju nisku razinu TP i TA. Ciljevi ovog projekta su: (1) Analizirati kurikulum TZK u razrednoj i predmetnoj nastavi; adaptacija i validacija mjernog instrumenta; (2) Utvrditi usklađenost kurikuluma TZK  s konceptom TP u razrednoj i predmetnoj nastavi; (3) Razviti, implementirati i utvrditi učinak intervencije usmjerene na poboljšanje TP na TF, TA, zdravstvenu pismenost i zdravstveni status kod učenika razredne i predmetne nastave. U istraživanju će sudjelovati: učitelji razredne nastave, učenici nižih razreda osnovne škole, učitelji predmetne nastave i učenici predmetne nastave. U prvoj fazi će se validirati i provesti upitnik kojim će se procijeniti koliko kurikulum TZK u razrednoj nastavi uključuje koncept TP. U drugoj fazi će se razviti i provesti intervencija te će se ispitati učinci intervencije na promjene u domenama TP, TF, TA, zdravstvene pismenosti i zdravstvenog statusa učenika razredne nastave. Faza 1 i Faza 2 će se u drugom dijelu projekta provesti i na učiteljima i učenicima predmetne nastave, istim rasporedom i koristeći gotovo iste metode. Očekuje se da će projekt rezultirati: (i) objektivnom evaluacijom kurikuluma TZK u pogledu utjecaja na poboljšanje TP predadolescenata i mlađih adolescenata (ii) adekvatnim modificiranjem/nadopunjavanjem kurikuluma TZK, (iii) egzaktnom provjerom učinkovitosti  primijenjenih intervencija u smislu unapređenja TP predadolescenata i mlađih adolescenata. Osim izravnih rezultata, očekuje se da će projekt imati i širi društveni utjecaj, kao i utjecaj na područje javnog zdravstva, a s obzirom na to da je orijentiran na jedan od većih problema današnjice, na tjelesnu neaktivnost.]]></summary_hr><summary_en><![CDATA[Physical literacy (PL) is a concept that can enhance experiences in physical education (PE) classes and encourage individual participation in physical activity (PA). PL is associated with improved physical fitness (PF), health literacy, and health status. Previous research in Croatia has shown that children have low levels of PL and PA. The objectives of this project are: (1) To analyze the PE curriculum in primary school; validation of measurement instrument; (2) To determine the compliance of the PE curriculum with the concept of PL in primary school children; (3) To develop, implement, and determine the effect of an intervention aimed at improving PL on PF, PA, and health status in students. The following groups will participate in the research: lower primary school teachers, lower primary school students, subject teachers, and subject students. In the first phase, a questionnaire will be validated and implemented to assess the extent to which the PE curriculum includes the concept of PL. In the second phase, an intervention will be implemented and the effects on changes in the subdomains of TP, TF, TA, health status of primary school students will be examined. Phase 1 and 2 will be implemented in the second part of the project on both teachers and students of subject classes, with the same schedule and using almost the same methods. It is expected that the project will result in: (i) an objective evaluation of the PE curriculum in terms of the impact on improving the PL of pre-adolescents and young adolescents (ii) an adequate addition to the PE curriculum, (iii) an exact verification of the effectiveness of the applied interventions in terms of improving the PL of preadolescents and young adolescents. In addition to direct results, it is expected that the project will have a wider social impact, as well as an impact on the field of public health, given that it is focused on one of the major problems of today, physical inactivity.]]></summary_en></project><project>
<id>17831</id><title_hr><![CDATA[Semantičko-sintaktička klasifikacija glagola u hrvatskom jeziku ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>2892</user_id><user_firstLast_name>Ivana Brač</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-2310</code><acronim><![CDATA[SEMTACTIC]]></acronim><duration>10.11.2025 - 09.11.2030</duration><status>U tijeku</status><financ_value>60,00 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filologija, </scie_field_hr><scie_field_en>Philology, </scie_field_en><institution_hr><![CDATA[Institut za hrvatski jezik]]></institution_hr><institution_en><![CDATA[Institute of Croatian Language]]></institution_en><team_members_id>872957</team_members_id><team_members_names><![CDATA[ Doktorand: Ivona Gašparić ]]></team_members_names><keywords_hr><![CDATA[semantika, sintaksa, glagoli, valencijski obrasci, semantičke uloge]]></keywords_hr><keywords_en><![CDATA[semantics, syntax, verbs, valency patterns, semantic roles]]></keywords_en><summary_hr><![CDATA[Ciljevi su projekta odrediti semantičke skupine kojima pripada 500 najčešćih glagola u hrvatskom jeziku, njihove prototipne sintaktičke obrasce i semantičke uloge, teorijski istražiti odnos semantike i sintakse glagola unutar jedne semantičke skupine i među skupinama te izraditi bazu u kojoj će se na primjerima iz korpusa temeljito semantički i sintaktički obraditi glagoli.U okviru projekta istraživat će se semantička obilježja glagola i odnosi sinonimije, antonimije, troponimije i dr., zatim uloga glagola u kognitivnim mehanizmima metafore i metonimije te će se istraživati sintaktičke alternacije i druge gramatičke pojave. Praktični je rezultat projekta baza s 500 najčešćih glagola u hrvatskom kojima će na temelju primjera iz korpusa biti određeno značenje, pridružena semantička skupina, određene vrste dopuna i njihove semantičke uloge. Podjelom glagola u semantičke skupine i njihovim valencijskim opisom uočit će se sličnosti i razlike među glagolima jedne skupine te između različitih skupina, što će rezultirati boljim razumijevanjem odnosa sintakse i semantike. Pregledno prikazani rezultati u bazi i u radovima omogućit će bolje uključivanje hrvatskoga jezika u poredbena istraživanja te moguću razmjenu podataka s drugim bazama koje se temelje na istom ili sličnom načelu razdiobe. Projekt je važan za obradu prirodnoga jezika zbog pouzdanoga i temeljitoga opisa sintaktičkih obrazaca i semantičkih uloga te diferenciranih značenja, stoga će se rezultati moći koristiti za parsiranje, automatsko označivanje teksta, označivanje semantičkih uloga, unapređenje alata za strojno prevođenje, izradu materijala za učenje jezika i dr. Rezultati će koristiti profesorima hrvatskoga, studentima svih jezičnih smjerova, lingvistima te neizvornim govornicima. Ujedno će se ojačati istraživačke kompetencije mladih istraživača i doktoranda samostalnim znanstvenim istraživanjem, stručnim usavršavanjem te sudjelovanjem na konferencijama. Baza će se dopunjavati i nakon završetka projekta.]]></summary_hr><summary_en><![CDATA[The goals of the project are to classify the 500 most frequent verbs in Croatian into semantic classes, to determine verbs’ prototypical syntactic patterns and semantic roles, to investigate the relationship between the semantics and syntax of Croatian verbs within one semantic class and between classes, and to create a database in which verbs will be thoroughly semantically and syntactically analyzed based on examples from corpora. In this project, the semantic features of verbs will be researched, as well as the role of verbs in the cognitive mechanisms of metaphor and metonymy, syntactic alternations and other grammatical phenomena. The practical result of the project will be a database with the 500 most frequent verbs in Croatian, for which, based on examples from the corpora, meanings will be determined, a semantic class will be associated with each meaning, and syntactic patterns and semantic roles will be assigned. By dividing verbs into semantic classes and their valency description, similarities and differences between verbs will be observed, which will result in a better understanding of the syntax-semantics interface. Structured and clearly presented results in the database and in published papers will enable a better inclusion of Croatian in comparative research and a possible exchange of similar data with other databases that are based on the same or similar principles of distribution. The project is important for NLP due to the thorough description of syntactic patterns and semantic roles and differentiated meanings; therefore, it could be used for parsing, semantic role labeling, the improvement of machine translation tools, the creation of language learning materials, etc. The results will benefit teachers of Croatian, students, linguists, and non-native speakers. Furthermore, the research competencies of young researchers and a doctoral student will be strengthened through independent scientific research, workshops and conferences.]]></summary_en></project><project>
<id>17833</id><title_hr><![CDATA[Uloga mitohondrija i lipidnih kapljica u disfunkciji masnog tkiva posredovanoj lipidnom peroksidacijom u  pretilosti ]]></title_hr><title_en><![CDATA[Mitochondria and lipid droplets in lipid peroxidation-mediated adipose tissue dysfunction in  obesity ]]></title_en><user_id>29126</user_id><user_firstLast_name>Morana Jaganjac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-7344</code><acronim><![CDATA[MiLDoxOb]]></acronim><duration>05.12.2025 - 04.12.2028</duration><status>U tijeku</status><financ_value>199.996,50 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, Clinical sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>703, 26040, 1208, 25214, 865788, 865753, 865794, 865858, 856146, 870540, 866325, </team_members_id><team_members_names><![CDATA[Sandra Sobočanec, Suzana Borovic Sunjic, Mirna Halasz, Anita Stojanović Marković, Ivo Soldo, Alen Pajtak, toni kolak, Peter Horvatovich Horvatovich, Elzbieta Skrzydlewska, Plamena Angelova (Stroh), Toni Petan, ]]></team_members_names><keywords_hr><![CDATA[Pretilost, mitohondriji, lipidne kapljice, lipidna peroksidacija, masno tkivo, adipociti, makrofazi]]></keywords_hr><keywords_en><![CDATA[Obesity, mitochondria, lipid droplets, lipid peroxidation, adipose tissue, adipocytes, macrophages]]></keywords_en><summary_hr><![CDATA[Stope pretilosti u Hrvatskoj među najvišima su u Europskoj uniji s više od 57% odraslih osoba s prekomjernom tjelesnom težinom. Premda značajan dio pretile populacije postaje otporno na fiziološke učinke inzulina (IR), mali postotak pretilih pojedinaca ostaje osjetljiv na inzulin (IS). U nastanku IR središnju ulogu ima disfunkcionalno masno tkivo. Poremećaj metabolizam lipida i funkcije mitohondrija te kronična upala usko su povezani s oksidacijskim stresom te posljedičnom peroksidacijom višestruko nezasićenih masnih kiselina (PUFA), čime nastaju reaktivni aldehidi. Rezultati našeg tima sugeriraju da su makrofazi masnog tkiva odgovorni za oksidaciju lipida i stvaranje reaktivnih aldehida, koji se nakupljaju u adipocitima i tako narušavaju redukcijsko/oksidacijsku homeostazu adipocita i adipogenezu, te potiču nastajanje IR. Reaktivni aldehidi također reguliraju funkciju mitohondrija te tako dovode do promjene metabolizma u adipocitima. Većina ovih puteva sastaje se u lipidnim kapljicama, dugo zanemarenim organelama za skladištenje masti, koji sudjeluju u regulaciji redukcijsko/oksidacijskog i mitohondrijskog metabolizma, kao i lipoksičnosti PUFA. Korištenjem novih pristupa i relevantnih staničnih modela, uključujući stanice dobivene iz masnog tkiva pretilih osoba, cilj nam je identificirati glavne molekulske čimbenike odgovorne za poremećaje akumulacije lipida, funkcije mitohondrija i lipidnu peroksidaciju (LPO). Predloženim projektom će se također omogućiti dublje razumijevanje stanične komunikacije adipocita i makrofaga pod utjecajem LPO. Proučavanje međudjelovanja dva organela ključna za kontrolu staničnog sastava lipida, energije i redukcijsko/oksidacijskog metabolizma, u kombinaciji s analizama uzoraka pacijenata, ukazati će na molekularne čimbenike odgovorne za fenotipske razlike IR/IS i otvoriti put za nove terapijske strategije za liječenje pretilosti i povezane IR, te tako ograničiti morbiditet i mortalitet povezan s pretilošću u Hrvatskoj i svijetu.]]></summary_hr><summary_en><![CDATA[Obesity rates in Croatia are among the highest in the European Union with over 57% of overweight adults. Although this has rendered a significant proportion of the population insulin resistant (IR), a small subset of obese individuals remains insulin sensitive (IS). Dysfunctional adipose tissue has a central role in the development of IR. Dysregulated lipid metabolism, impaired mitochondrial function, and chronic inflammation are closely associated with oxidative stress and subsequent peroxidation of polyunsaturated fatty acids (PUFAs), yielding reactive aldehydes. Work from our team suggests that adipose tissue macrophages are responsible for the oxidation of lipids and formation of reactive aldehydes, which accumulate in adipocytes and account for altered redox homeostasis, impaired adipogenesis, and induction of IR. Reactive aldehydes also regulate mitochondrial function and energy production triggering a shift in bioenergetics of adipocytes. Most of these pathways converge at lipid droplets, long neglected fat storage organelles with emerging roles in the regulation of redox and mitochondrial metabolism as well as PUFA lipotoxicity. Using novel approaches and relevant cellular models, including patient adipose tissue-derived cells, we aim to identify the major molecular pathways underlying the elusive relationship between dysregulated lipid accumulation, mitochondrial function, and lipid peroxidation (LPO). This work will also provide a deeper understanding of the altered adipocyte-macrophage crosstalk modulated by LPO. The study of the interplay between the two organelles crucial for controlling cellular lipid composition, energy and redox metabolism, combined with the analyses of patient samples, will pinpoint molecular targets responsible for the IR/IS phenotype differences and pave the path for novel therapeutic strategies for treating obesity and associated IR, and limit obesity-associated morbidity and mortality in the Croatia and worldwide.]]></summary_en></project><project>
<id>17835</id><title_hr><![CDATA[Afine Liejeve algebre i kvantne grupe]]></title_hr><title_en><![CDATA[Affine Lie algebras and quantum groups]]></title_en><user_id>687</user_id><user_firstLast_name>Marijana Butorac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-4720</code><acronim><![CDATA[AffineLAQ]]></acronim><duration>31.12.2025 - 30.12.2028</duration><status>U tijeku</status><financ_value>119.700,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Fakultet za matematiku]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Mathematics]]></institution_en><team_members_id>636, 638, 864884, </team_members_id><team_members_names><![CDATA[Slaven Kožić, Mirko Primc, Marina Sertić, ]]></team_members_names><keywords_hr><![CDATA[afine Liejeve algebre, kvantne grupe, kvantne verteks algebre, glavni potprostori, Rogers-Ramanujanovi identiteti]]></keywords_hr><keywords_en><![CDATA[affine Lie algebras, quantum groups, quantum vertex algebras, principal subspaces, Rogers-Ramanujan identities]]></keywords_en><summary_hr><![CDATA[U predloženom projektu provodit će se istraživanje u području kvantnih grupa, kvantnih verteks algebri i kombinatorne teorije reprezentacija afinih Liejevih algebri. Glavni cilj je podržati i koordinirati istraživačke aktivnosti skupine istraživača u tim komplementarnim područjima. U teoriji kvantnih verteks algebri, glavni problemi koji će se istraživati su vezani za strukturu Etingof-Kazhdanovih kvantnih verteks algebri pridruženih trigonometrijskim R-matricama s posebnim naglaskom na razvoj teorije deformiranih fi-koordinatnih modula što će dovesti do novih primjena na brojne klase kvantnih algebri pridruženih trigonometrijskim R-matricama. U teoriji reprezentacija afinih Liejevih algebri glavni problemi koje ćemo istraživati vezani su za konstrukcije kombinatornih baza glavnih potprostora standardnih modula afinih Liejevih algebri što će dovesti do novih primjena u proučavanju kombinatornih identiteta.]]></summary_hr><summary_en><![CDATA[In the proposed project, research will be conducted in the field of quantum groups, quantum vertex algebras and combinatorial representation theory of affine Lie algebras. The main goal is to support and coordinate the research activities of a group of researchers in these complementary areas. In the theory of quantum vertex algebras, the main problems that will be investigated are related to the structure of Etingof-Kazhdan&#39;s quantum vertex algebras associated with trigonometric R-matrices with special emphasis on the development of the theory of deformed phi-coordinated modules which will lead to new applications to numerous classes of quantum algebras associated with trigonometric R-matrices. In the theory of representations of affine Lie algebras the main problems which we will investigate are related to the construction of combinatorial bases of principal subspaces of standard modules of affine Lie algebras which will lead to new applications in the study of combinatorial identities.]]></summary_en></project><project>
<id>17841</id><title_hr><![CDATA[Popravak križnih veza topoizomeraza i DNA in vivo koristeći model zebrice ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4272</user_id><user_firstLast_name>Marta Popović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-7130</code><acronim><![CDATA[TOPCROSS]]></acronim><duration>19.01.2026 - 18.01.2031</duration><status>U tijeku</status><financ_value>60,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>873005</team_members_id><team_members_names><![CDATA[ Doktorand: Leona Verasto ]]></team_members_names><keywords_hr><![CDATA[DNA oštećenja i popravak, križne veze DNA i proteina, topoizomeraza 1 i 2, zebrica, tirozil-DNA fosfodiesteraza 1 i 2, CRISPR]]></keywords_hr><keywords_en><![CDATA[DNA damage and repair, DNA-protein crosslinks, topoisomerase 1 and 2, zebrafish, tyrosyl-DNA phosphodiesterase 1 i 2, CRISPR]]></keywords_en><summary_hr><![CDATA[Križne veze DNA i proteina (DNA-protein crosslink, DPC) su česta oštećenja DNA koja nastaju ireverzibilnim kovalentnim vezanjem proteina i DNA. Ove glomazne lezije ometaju sve DNA transakcije, pa su stoga posljedice poremećenog popravka DPC oštećenja vrlo ozbiljne. Na staničnoj razini, neispravni popravak uzrokuje lomove DNA, genomsku nestabilnost i staničnu smrt, dok je na razini organizma poremećeni DPC popravak povezan s rakom, starenjem i neurodegeneracijom. Topoizomeraze (TOP) su među najzastupljenijim DPC oštećenjima u stanicama u fiziološkim uvjetima, a induceri TOP-DPC oštećenja kao što su topotekan i etopozid koriste se za liječenje raznih vrsta raka. Tirozil-DNA fosfodiesteraze (TDPs) su enzimi koji uklanjaju umrežene peptidne ostatke topoizomeraze iz DNA, a njihov nedostatak uzrokuje neurološke probleme kod miševa i ljudi. Unatoč mnogim naporima, popravak ovih visoko toksičnih oštećenja DNA još uvijek nije u potpunosti shvaćen. Istražit ćemo (1) koji su proteini ključni za popravak TOP1- i TOP2-DPC in vivo i jesu li epistatični, (2) vezu između TOP-DPC popravka i neuroloških defekata u organizmu s manjkom TDP-a, i (3) akumuliraju li se TOP-DPC u organizmu koji stari. Naš pristup uključuje: (a) utišavanje gena čimbenika popravka TOP-DPC oštećenja: sprtn, acrc, zatt, tex264, apex1, 2 i mre11 i inhibiciju ATPaze p97 i proteasoma u embrijima zebrica divljeg tipa i s nedostatkom Tdp enzima, (b) stvaranje tdp1 i tdp2 dvostrukih mutantnih sojeva zebrica, (c) karakterizaciju DPC profila u različitim pozadinama genske manipulacije u embrijima i različitim tkivima tijekom starenja, i (d) identifikaciju neuroloških promjena uključujući ataksiju, anksioznost, učenje i pamćenje kod odraslih riba s nedostatkom Tdp1 i Tdp2. Predloženi projekt bit će prvi koji će istraživati TOP-DPC popravak na razini organizma. To će poboljšati naše razumijevanje ljudskih bolesti i starenja i moglo bi dovesti do identifikacije novih lijekova za liječenje raka i neuroloških bolesti.]]></summary_hr><summary_en><![CDATA[DNA-protein crosslinks (DPCs) are frequent DNA lesions caused by irreversible covalent bonds between proteins and DNA. These bulky lesions hinder all DNA transactions, and therefore the consequences of impaired DNA-Protein Crosslink Repair (DPCR) are severe. At the cellular level, defective repair causes DNA breaks, genomic instability, and cell death, while at the organismal level, impaired DPCR is associated with cancer, aging, and neurodegeneration. Topoisomerases (TOPs) are among the most abundant DPCs in cells under physiological conditions and TOP-DPC inducers such as topotecan and etoposide are used to treat various cancers. Tyrosyl-DNA phosphodiesterases (TDPs) are enzymes that remove crosslinked topoisomerase peptide residues from the DNA and their deficiency leads to neurological defects in mice and humans. Despite many efforts, the repair of these highly toxic DNA lesions is still not fully understood. We will investigate (1) which proteins are crucial for the repair of TOP1- and TOP2-DPCs in vivo and whether they are epistatic, (2) link between TOP-DPCR and the neurological defects in TDP-deficient organism, and (3) whether TOP-DPCs accumulate in the aging organism. Our approach includes: (a) gene silencing of TOP-DPC repair factors: sprtn, acrc, zatt, tex264 apex1, 2 and mre11 and inhibition of ATPase p97 and proteasome in WT and Tdp-deficient zebrafish embryos, (b) generation of tdp1 and tdp2 double mutant zebrafish strains, (c) characterization of DPC profiles in different backgrounds of gene manipulation in embryos and in different tissues during aging, and (d) identification of neurological changes including ataxia, anxiety, learning and memory in Tdp1- and Tdp2-deficient adult fish. The proposed project will be the first to investigate TOP-DPC repair at the organismal level. It will improve our understanding of human disease and aging and could lead to the identification of new drug targets for the treatment of cancer and neurological diseases.   ]]></summary_en></project><project>
<id>17843</id><title_hr><![CDATA[Višenamjenska vanjska ionska mikroproba za ozračavanje i analizu]]></title_hr><title_en><![CDATA[Multipurpose External Ion Microprobe for Irradiation and Analysis ]]></title_en><user_id>4976</user_id><user_firstLast_name>Iva Božičević Mihalić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2025-02</proposal_call><code>UIP-2025-02-1551</code><acronim><![CDATA[MEXIA]]></acronim><duration>01.04.2026 - 31.03.2031</duration><status>U tijeku</status><financ_value>299.687,50 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, Interdisciplinarne prirodne znanosti, </scie_field_hr><scie_field_en>Physics, Interdisciplinary natural sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>5947, 869771, 869968, 21267, 868775, </team_members_id><team_members_names><![CDATA[Donny Domagoj Cosic, Fares Boussahoul, Sabrina Gouasmia, Kristina Tomić Luketić, Karla Ivanković Nizić, ]]></team_members_names><keywords_hr><![CDATA[External Ion Microprobe, radiation detectors, radiophotoluminescent dosimeters, radiobiological effects, hadron therapy]]></keywords_hr><keywords_en><![CDATA[Vanjska ionska mikroproba, detektori zračenja, radiofotoluminiscentni dozimetri, radiobiološki efekti, hadronska terapija]]></keywords_en><summary_hr><![CDATA[Ovaj projekt predlaže značajnu nadogradnju vanjske ionske mikrosonde IRB-a, usredotočenu na ugradnju specijalizirane vakuumske komore. Ova nadogradnja će implementirati praćenje toka ionskog snopa za eksperimente u vakuumu i zraku, omogućavajući preciznu kontrolu doze i IBA kvantifikaciju, posebice za uzorke neprikladne za vakuum (npr., biološki uzorci i artefakti kulturne baštine). Ključna komponenta projekta je istraživanje učinkovitosti prikupljanja naboja (CCE) širokopojasnih poluvodičkih detektora zračenja, za što je precizno praćenje doze neophodno. Koristeći kriogeni sustav (300 K do 40 K), CCE će se mjeriti s različitim ionima (od H do C) prije i poslije ozračivanja različitim dozama i temperaturama, pružajući referentne podatke za procjenu performansi detektora nakon ozračivanja. Nadalje, dostupnost protona viših energija (do 10 MeV) i teških iona, u kombinaciji s preciznim praćenjem doze, omogućit će daljnju karakterizaciju luminescentnih detektora (RPL) za hadronsku terapiju. Dozimetrijska istraživanja provodit će se s Laboratorijem za radijacijsku kemiju i dozimetriju IRB-a, koji će osigurati dozimetre i mjeriti RPL signale nakon ozračivanja, što je ključno za pouzdanu upotrebu dozimetara. Interdisciplinarna suradnja s Laboratorijem za personaliziranu medicinu (LPM) na IRB-u demonstrirat će sposobnosti sustava za istraživanje radiobioloških učinaka ionskih snopova na stanice raka ozračivanjem protonima, a kasnije i težim ionima, nakon čega slijedi procjena radiobioloških učinaka. Komora će također sadržavati PIXE detektor velikog prostornog kuta, što će olakšati submikrometarsku analizu različitim IBA metodama. Interdisciplinarno istraživanje uključivat će suradnju s Arheološkim muzejom u Zagrebu, Institutom za arheologiju i/ili Hrvatskim restauratorskim zavodom. Oni će osigurati uzorke, usredotočujući se na PIXE snimanje manjih uzoraka visoke razlučivosti u vakuumu i analizu većih objekata koji nisu kompatibilni s vakuumom.]]></summary_hr><summary_en><![CDATA[This project proposes a significant upgrade to the RBI&#39;s external ion microprobe, centered on a installation of specialized vacuum chamber. This upgrade will implement ion beam fluence monitoring for both in-vacuum and in-air experiments, enabling precise dose control and IBA quantification, especially for samples unsuitable for vacuum (e.g., biological samples and cultural heritage artifacts). A key project component is investigating the charge collection efficiency (CCE) of wide bandgap semiconductor radiation detectors for which price dose monitoring is mandatory. Using a cryogenic setup (300 K to 40 K), CCE will be measured with various ions (H to C) before and after irradiation at different doses and temperatures, providing benchmark data for evaluating post-irradiation detector performance. Furthermore, the availability of higher energy protons (up to 10 MeV) and heavy ions, combined with precise dose monitoring, will enable further characterization of luminescent detectors (RPL) for hadron therapy. Dosimetric investigations will be conducted with the RBI&#39;s Radiation Chemistry and Dosimetry Laboratory, who will provide dosimeters and measure post-irradiation RPL signals, study crucial for reliable dosimeter use. Interdisciplinary collaboration with the Laboratory for Personalized Medicine (LPM) at RBI will demonstrate the system&#39;s capabilities for investigating the radiobiological effects of ion beams on cancer cells by irradiation with protons and later, heavier ions followed by assessment of radiobiological effects. The chamber will also house a large solid angle PIXE detector, facilitating sub-micrometer analysis with different IBA methods. Interdisciplinary research will involve collaborating with the Archaeological Museum in Zagreb, the Institute of Archaeology, and/or the Croatian Conservation Institute. They will provide samples, focusing on high-resolution in-vacuum PIXE imaging of smaller samples and analysis of larger, non-vacuum-compatible objects.]]></summary_en></project><project>
<id>17847</id><title_hr><![CDATA[Integracija fitoremedijacije, sekvestracije ugljika i proizvodnje energije uzgojem energetskih kultura]]></title_hr><title_en><![CDATA[Integration of phytoremediation, carbon sequestration and energy production by energy crops cultivation]]></title_en><user_id>5608</user_id><user_firstLast_name>Nikola Bilandžija</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-3741</code><acronim><![CDATA[PHYTO-CE]]></acronim><duration>29.12.2025 - 28.12.2028</duration><status>U tijeku</status><financ_value>199.985,00 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, Biotehnologija, </scie_field_hr><scie_field_en>Agriculture, Biotechnology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Agronomski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Agriculture]]></institution_en><team_members_id>19006, 5696, 5606, 19029, 867987, 6021, 19017, 867764, 867771, 6018, 23367, 865660, 1510, 867989, 19643, 25226, </team_members_id><team_members_names><![CDATA[Josip Leto, Željka Zgorelec, Neven Voća, Darija Bilandžija, Lato Pezo, Tibela  Landeka Dragičević, Aleksandra Perčin, Igor Kovačev, Krešimir Čopec, Dijana Grgas, Silva Žužul, Jasmina Rinkovec, Irena Krešić, Milada Pezo, Mateja Grubor, Anamarija Peter, ]]></team_members_names><keywords_hr><![CDATA[Tlo, onečišćenje, sanacija, biomasa, višekriterijska analiza]]></keywords_hr><keywords_en><![CDATA[Soil, pollution, remediation, biomass, multicriteria analysis]]></keywords_en><summary_hr><![CDATA[Tijekom 3 godine uzgajati će se dvije energetske kulture (miskantus/divovska trska) u ex-situ uvjetima s potencijalno onečišćenim marginalnim tlom (ilegalno odlagalište otpada), sa/bez primjene poboljšivača tla. Planira se istražiti mogućnost očuvanja/sanacije tla fitoremedijacijom, kao i ublažavanje klimatskih promjena korištenjem krutih biogoriva, povećanjem ponora ugljika (sekvestracijom u biomasu i tlo) te smanjenjem izvora ugljika (disanje tla i biljke). Specifičnim ciljevima će se: (1) Identificirati potencijalni tipovi onečišćenja tla i mogućnosti fitoremedijacije istraživanim kulturama/poboljšivačem tla; (2) Utvrditi porast biomase te biološki i gospodarski prinos; (3) Utvrditi energetska svojstva biomase i valorizirati utjecaj onečišćenja na korištenje biomase u proizvodnji krutih biogoriva; (4) Utvrditi utjecaj različitih pedo-klimatskih čimbenika, vrste energetske kulture i primjene pobošljivača tla na kruženje ugljika (izvore i ponore) u sustavu tlo-biljka-atmosfera; (5) Razviti modele i proračunati biološki, gospodarski, fitoremedijacijski, energetski i potencijal biološke sekvestracije ugljika istraživanih kultura primjenom strojnog učenja. Za ostvarivanje ciljeva provesti će se: (a) fizikalne, kemijske i elementarne analize tla te identifikacija prisutnosti i tipa onečistila; (b) elementarne analize podzemne biomase; (c) elementarne i energetske analize nadzemne biomase; (d) praćenje agroekoloških uvjeta i kruženja ugljika na 1 ex-situ i 2 in-situ lokacije. Nova saznanja doprinijeti će boljem razumijevanju sanacije tala fitoremedijacijom, proizvodnje bioenergije, kao i kompleksnosti interakcije čimbenika agroekosustava na tokove ugljika. Sveukupno će doprinijeti boljoj provedbi mjera okvira za klimu, energiju i okoliš, kvantificiranju izvora i ponora C te stvaranju temelja za prijelaz na više razine IPCC izvješćivanja.]]></summary_hr><summary_en><![CDATA[Over a period of three years, two energy crops (miscanthus/giant reed) will be cultivated under ex-situ conditions on potentially contaminated marginal soils (illegal landfill), with/without the use of soil conditioners. It is planned to investigate the possibility of soil conservation and remediation through phytoremediation as well as climate protection through the use of solid biofuels, the increase of carbon sinks (sequestration in biomass and soil) and the reduction of carbon sources (soil and plant respiration). The specific objectives are to: (1) identify potential types of marginal soil pollution and potential for phytoremediation by studied plants/conditioner; (2) determine biomass increase and biological yields; (3) determine energetic biomass properties and valorize impact of pollution on production of solid biofuels; (4) determine impact of different pedo-climatic factors, studied crop types and application of soil conditioner on C cycling (sources and sinks) in soil-plant-atmosphere system; (5) Develop models and calculate biological, economic, phytoremediation, energetic and biological carbon sequestration potential of studied crops using machine learning techniques. Following will be conducted: (a) physical, chemical and elemental soil analyses and identification of presence and type of contaminants; (b) elemental analyses of belowground biomass; (c) elemental and energetic analyses of aboveground biomass; (d) monitoring of agroecological conditions and C cycling at 1 ex-situ and 2 in-situ sites. Results will contribute to a better understanding of soil remediation by phytoremediation, bioenergy production and the complexity of interactions between agroecosystem and carbon cycle that will ultimately contribute to better implementation of sustainable measures for climate, energy and environmental protection, quantification of C sources and sinks, and to provide basis for improving the IPCC reporting for higher levels of methodology.]]></summary_en></project><project>
<id>17850</id><title_hr><![CDATA[Uloga adiponektina u biologiji memorijskih CD8 T stanica]]></title_hr><title_en><![CDATA[]]></title_en><user_id>19737</user_id><user_firstLast_name>Marko Šestan</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-9121</code><acronim><![CDATA[RAMBO]]></acronim><duration>28.01.2026 - 27.01.2032</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Medicine]]></institution_en><team_members_id>873092</team_members_id><team_members_names><![CDATA[ Doktorand: Sanja Skok ]]></team_members_names><keywords_hr><![CDATA[Adiponektin, memorijske stanice CD8 T, dijabetes melitus tip 2, virusna infekcija, metabolizam, imunitet]]></keywords_hr><keywords_en><![CDATA[Adiponectin, memory CD8 T cells, diabetes mellitus type 2, viral infection, metabolism, immunity]]></keywords_en><summary_hr><![CDATA[Imunosni i endokrini sustav zamršeno su povezani. Imunosni sustav pokreće metaboličke promjene kao odgovor na infekciju, koje se u našem tijelu prepoznaju kao simptomi bolesti. Na taj način kao i podešavanjem endokrine signalizacije, imunosni sustav doprinosi boljoj borbi protiv infekcije. S druge strane, i endokrini hormoni imaju snažan utjecaj na imunološke stanice čime se osigurava da se njihova potrošnja prilagodi sustavnoj dostupnosti. Međutim, većina imunomodulatornih učinaka hormona još uvijek nije dovoljno istražena. Nove spoznaje u tom prodručju su od naročite važnosti za pacijente s metaboličkim bolestima poput dijabetesa tipa 2 (T2D), koji imaju poremećaj u radu endokrinog sustavaa, a uz to su i osjetljiviji na infekcije. Limfociti CD8 T izražavaju vrlo visoku razinu receptora za endokrini hormon adiponektin. Ovaj hormon potječe iz masnog tkiva, a naši preliminarni podaci ukazuju na to da potiče stvaranje memorijskih stanica. U ovom projektu istražit ćemo specifičan učinak adiponektina na memorijske limfocite CD8 T te odgovoriti na pitanje igra li ulogu u poremećaju funkcije imunoloških stanica u kontekstu T2D. Korištenjem već uspostavljenih in vitro i in vivo modela te genetski modificiranih miševa odredit ćemo specifičnu ulogu ovog hormona u memorijskim stanicama. Kombinacijom napredne proteomike, transkriptomike i metabolomike razjasnit ćemo molekularne mehanizme putem kojih ovaj faktor utječe na memorijske stanice. S već uspostavljenim mišjim modelima za metaboličke bolesti odredit ćemo specifičnu ulogu adiponektina u poremećaju funkcije memorijskih limfocita CD8 T u kontekstu T2D. Konačno, analizom stanica zdravih ljudskih dobrovoljaca, kao i pacijenata s T2D-om, potvrdit ćemo važnost naših nalaza za ljude. Ukratko, naš projekt će dodatno pojasniti imunološko-endokrine interakcije u zdravlju i u kontekstu metaboličkih bolesti. ]]></summary_hr><summary_en><![CDATA[The immune and endocrine systems are intricately linked. In response to infection the immune system mediates metabolic changes in our body, generally referred to as sickness behavior, by adjusting endocrine signaling, with the purpose to better fight infection. Conversely, endocrine hormones have a profound impact on immune cells to ensure that their consumption is adjusted to the systemic availability. However, much of the immunomodulatory effects of hormones is unknown. This is of particular importance in for patients with metabolic disease such as Type 2 diabetes (T2D), who have endocrine dysregulation and are also more susceptible to infection. CD8 T cells express very high levels of the receptors for the endocrine hormone adiponectin and our preliminary data indicates that this adipose tissue-derived hormone promotes memory cell formation. In this project we will investigate the specific effect of adiponectin on memory CD8 T cells and whether it plays a role in immune cell dysfunction in context of T2D. By using established in vitro and in vivo models in combination with genetically modified mice, we will determine the specific role of this hormone in memory cells. With a combination of advanced proteomics, transcriptomics and metabolomics, we will elucidate the molecular mechanisms via which this factor mediates its effect in memory cells. With our established mouse models for metabolic disease, we will determine the specific role of adiponectin in memory CD8 T cell disfunction in context of T2D. Finally, by analyzing cells from healthy human volunteers, as well as of patients with T2D, we will confirm the relevance of our findings for the human situation. In summary, our project will shed important new light on immune-endocrine interactions in health and in context of metabolic disease. ]]></summary_en></project><project>
<id>17855</id><title_hr><![CDATA[Sustav temeljen na umjetnoj inteligenciji za otkrivanje urođenih anomalija mozga i srca fetusa]]></title_hr><title_en><![CDATA[System based on artificial intelligence for detecting congenital anomalies of the fetal brain and heart]]></title_en><user_id>855327</user_id><user_firstLast_name>Jelena Božek</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-8365</code><acronim><![CDATA[FetalAI]]></acronim><duration>08.12.2025 - 07.12.2028</duration><status>U tijeku</status><financ_value>198.900,00 eur</financ_value><scie_area_hr>Tehničke znanosti, Biomedicina i zdravstvo, Interdiciplinarne znanosti, </scie_area_hr><scie_area_en>Technological sciences, Biomedicine and health sciences, Interdisciplinary scientific area, </scie_area_en><scie_field_hr>Računarstvo, Elektrotehnika, Temeljne medicinske znanosti, Kliničke medicinske znanosti, Interdisciplinarne tehničke znanosti, </scie_field_hr><scie_field_en>Computer sciences, Electrical engineering, Basic Medical Sciences, Clinical sciences, Interdisciplinary technological sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>12951, 26560, 870367, 3645, 3529, 870316, 870254, 870336, 870231, 12770, 870462, 870270, </team_members_id><team_members_names><![CDATA[Ivica Kostović, Sonja Grgić, Mislav Grgić, Mihaela Vranić, Damir Pintar, Ana Šarčević, Kristina Ćaleta, Nenad Veček, Ivan Zmijanović, Lea Smirčić Duvnjak, Tomislav Božek, Ana Čolić, ]]></team_members_names><keywords_hr><![CDATA[anomalije mozga, prirođene srčane greške, dijabetes, duboko učenje, strojno učenje, umjetna inteligencija]]></keywords_hr><keywords_en><![CDATA[brain anomalies, congenital heart defects, diabetes, deep learning, machine learning, artificial intelligence ]]></keywords_en><summary_hr><![CDATA[Izazovi prenatalne dijagnostike uključuju teško prepoznavanje suptilnih abnormalnosti koje nisu jasno vidljive na ultrazvuku, dok iskustvo stručnjaka i trudnoće visokog rizika unose dodatne dijagnostičke izazove. Cilj ovog projekta je razviti inovativni sustav temeljen na umjetnoj inteligenciji (UI) za rano otkrivanje urođenih anomalija mozga i srca fetusa, s ciljem poboljšanja prenatalne dijagnostike i skrbi. U projektu će se izraditi baza ultrazvučnih slika mozga i srca fetusa sa zdravim razvojem i s anomalijama. Uz slike, uključit će se informacije o rizičnom čimbeniku dijabetesa kod trudnica i ishodima trudnoće. Baza podataka bit će ključna za razvoj modela UI za automatsko prepoznavanje fetalnih anomalija. Razvit će se dva specifična modela – jedan za prepoznavanje anomalija mozga fetusa i drugi za prepoznavanje prirođenih srčanih grešaka. Ovi modeli temeljit će se na metodama dubokog i strojnog učenja te će biti optimizirani za visoku točnost i validirani usporedbom s postnatalnim dijagnostičkim podacima. Projekt uključuje istraživanje i primjenu naprednih tehnika poput prijenosnog učenja i augmentacije podataka kako bi se povećala učinkovitost i generalizacija modela, čime će se poboljšati performanse u prepoznavanju fetalnih anomalija. Posebna pažnja bit će posvećena razvoju objašnjivih modela, koji će omogućiti liječnicima da razumiju odluke koje sustav donosi i povećati povjerenje u korištenje ovakvih tehnologija u svakodnevnoj praksi. Dodatno, istražit će se utjecaj prenatalnih anomalija u kombinaciji s rizičnim čimbenikom dijabetesa na razvojne ishode fetusa. Razvit će se prediktivni model koji će integrirati ultrazvučne i kliničke podatke za predikciju dugoročnih ishoda trudnoće. Cilj ovog projekta je razviti alat koji će unaprijediti kvalitetu prenatalne skrbi, smanjiti rizik od neprepoznatih fetalnih anomalija i pružiti dragocjene informacije za daljnja istraživanja i razvoj u području prenatalne medicine i umjetne inteligencije.]]></summary_hr><summary_en><![CDATA[Challenges in prenatal diagnostics include the difficulty of detecting subtle abnormalities that are not clearly visible on ultrasound, while expert experience and high-risk pregnancies add additional diagnostic challenges. The project aims to develop an innovative artificial intelligence (AI)-based system for the early detection of congenital brain and heart anomalies in fetuses, with the goal of improving prenatal diagnostics and care. The project will create a database of fetal brain and heart ultrasound images with healthy development and anomalies. Along with the images, information about the risk factor of diabetes in pregnant women and pregnancy outcomes will be included. The database will be key for developing AI models for automatic detection of fetal anomalies. Two specific models will be developed – one for detecting brain anomalies and another for detecting congenital heart defects. These models will be based on machine and deep learning methods, optimized for high accuracy, and validated by comparison with postnatal diagnostic data. The project will also explore advanced techniques such as transfer learning and data augmentation to improve model efficiency and generalization, thereby enhancing performance in detecting fetal anomalies. Special attention will be given to the development of explainable models, allowing doctors to understand the decisions made by the system and increasing trust in using such technologies in everyday practice. Additionally, the impact of prenatal anomalies combined with the risk factor of diabetes on fetal developmental outcomes will be investigated. A predictive model will be developed to integrate ultrasound and clinical data for predicting long-term pregnancy outcomes. The goal of this project is to develop a tool that will improve the quality of prenatal care, reduce the risk of undetected fetal anomalies, and provide valuable insights for further research and development in the fields of prenatal medicine and AI.]]></summary_en></project><project>
<id>17859</id><title_hr><![CDATA[Istraživanje interakcija proteina Keap1 u cilju otkrivanja novih terapijskih strategija]]></title_hr><title_en><![CDATA[Investigating Keap1 Protein Interactions to Uncover New Therapeutic Strategies ]]></title_en><user_id>2975</user_id><user_firstLast_name>Antonija Tomić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-7100</code><acronim><![CDATA[Keap1-InterThera]]></acronim><duration>05.12.2025 - 04.12.2028</duration><status>U tijeku</status><financ_value>199.985,00 eur</financ_value><scie_area_hr>Prirodne znanosti, Biomedicina i zdravstvo, </scie_area_hr><scie_area_en>Natural sciences, Biomedicine and health sciences, </scie_area_en><scie_field_hr>Kemija, Biologija, Temeljne medicinske znanosti, Farmacija, </scie_field_hr><scie_field_en>Chemistry, Biology, Basic Medical Sciences, Pharmaceutical sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>23593, 866713, 730, 2974, 27544, 870355, 4619, </team_members_id><team_members_names><![CDATA[Filip Šupljika, Marina Oskomić, Ana Tomašić Paić, Sanja Tomić, Antonia Matić, Vladimir Sladek, Mihaela Matovina, ]]></team_members_names><keywords_hr><![CDATA[Keap1, DPP III, aktin, protein-protein interakcije, inhibitori, prijenos signala, stanične migracije]]></keywords_hr><keywords_en><![CDATA[Keap1, DPP III, actin, protein-protein interactions, inhibitors, cell signaling, cell migration]]></keywords_en><summary_hr><![CDATA[Protein Keap1 primarno djeluje kao represor proteina Nrf2, služeći kao ključna komponenta signalnog puta Keap1-Nrf2, koji je glavni regulator staničnog odgovora na oksidativni i elektrofilni stres. Aktivacija Nrf2 štiti normalne stanice od različitih toksičnih agensa i bolesti, dok je prekomjerna aktivacija Nrf2 povezana s razvojem raka i rezistencijom na kemoterapiju i radioterapiju, što čini Keap1 privlačnom metom za prevenciju i liječenje bolesti i stanja povezanih s oksidativnim stresom. Osim što štiti tumorske stanice od oksidativnog oštećenja, dugotrajna aktivacija Nrf2 također znatno utječe na pokretljivost stanica i metastaze, potičući migraciju i invaziju stanica. U ovom projektu ciljamo istražiti ulogu interakcija između Keap1 i proteina DPP III i aktina, koji su pod određenim uvjetima povezani s razvojem raka i tumorskim metastazama. Oba proteina interagiraju s Kelch domenom proteina Keap1. Konkretno, istraživanja na staničnim linijama raka pluća i dojke sugeriraju da prekomjerno eksprimiran protein DPP III kompetira s Nrf2 za vezanje na Keap1, potičući njegovu translokaciju u jezgru te ekspresiju gena koji kodiraju antioksidativne enzime. Stoga je naš cilj identificirati molekulu koja bi mogla inhibirati &#39;&#39;moonlighting&#39;&#39; aktivnost DPP III u signalnom putu Keap1-Nrf2 i tako neposredno pojačati interakciju između Keap1 i Nrf2, utišavajući Nrf2-ovisnu ekspresiju gena u stanicama raka. Keap1 direktnim vezanjem na aktin, sudjeluje u regulaciji dinamike i funkcije citoskeleta. Narušavanje aktinskih filamenata može poremetiti interakciju Nrf2-Keap1, potičući aktivaciju Nrf2. Istraživanje interakcije Keap1-aktin može rasvijetliti potencijalnu ulogu Keap1 u dinamici aktinskog citoskeleta i migraciji stanica, pružajući uvid u nove terapijske strategije za bolesti povezane s oksidativnim stresom.]]></summary_hr><summary_en><![CDATA[The Keap1 protein primarily acts as a repressor of Nrf2, serving as a crucial component of the Keap1–Nrf2 signaling pathway, which is the primary regulator of oxidative and electrophilic stress response in the cell. While the activation of Nrf2 protects normal cells from various toxic agents and diseases, overactivation of Nrf2 has been linked to cancer progression and resistance to chemotherapy and radiotherapy, making Keap1 an attractive target for the prevention and treatment of oxidative stress-related diseases and conditions. In addition to protecting cancer cells from oxidative damage, persistent Nrf2 activation has also been found to significantly impact cell mobility and metastasis, facilitating cell migration and invasion. In this project, we aim to explore the role of interactions between Keap1 and DPP III and actin proteins, respectively, which under specific conditions have been correlated with cancer development and tumor metastasis. Both proteins have been found to engage in interactions with the Kelch domain of the Keap1 protein. Specifically, studies on lung and breast cancer cell lines have suggested that the overexpressed DPP III protein competes with Nrf2 for Keap1 binding, resulting in Nrf2 translocation to the nucleus and expression of antioxidant genes. Hence, our objective is to identify a molecule that could inhibit the moonlighting activity of DPP III in the Keap1–Nrf2 pathway, indirectly enhancing the interaction between Keap1 and Nrf2, thereby suppressing Nrf2-induced gene expression in cancer cells. By directly binding to actin, Keap1 participates in regulating cytoskeletal dynamics and functions. Disrupting actin filaments can disturb the Nrf2–Keap1 interaction, promoting Nrf2 activation. Investigation of the Keap1-actin interaction could shed light on the potential role of Keap1 in actin cytoskeleton dynamics and cell migration, offering insights into novel therapeutic strategies for diseases associated with oxidative stress.]]></summary_en></project><project>
<id>17864</id><title_hr><![CDATA[Ljudski prenatalni cerebralni neksus: neistražen prostorno-vremenski višerazmjerni kompartmentalni translacijski pristup]]></title_hr><title_en><![CDATA[]]></title_en><user_id>855327</user_id><user_firstLast_name>Jelena Božek</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-2710</code><acronim><![CDATA[HUMANCOMPARTMENTOME]]></acronim><duration>03.11.2025 - 02.11.2031</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>872893</team_members_id><team_members_names><![CDATA[ Doktorand: Marta Vidas ]]></team_members_names><keywords_hr><![CDATA[mozak fetusa čovjeka, kortikogeneza, prolazni sinaptički odjeljci, prematurus, translacija]]></keywords_hr><keywords_en><![CDATA[human fetal brain, corticogenesis, transient synaptic compartments, premature infants, translation]]></keywords_en><summary_hr><![CDATA[Glavni cilj je sinteza i integracija vremensko-prostornih pokazatelja histogenetskih događaja u prolaznim laminarnim odjeljcima mozga na višerazmjernim skalama razlučivanja (od nanoskale EM do makroskale na MR) i dovesti te parametre u prostorni odnos s razmještajem talamokortikalnih neuronskih veza: sinapsa, presinaptičkih aksona i postsinaptičkih elemenata u SP (subplate), CP (kortikalna ploča) i MZ (marginalna zona). Ti ciljevi povezani su preko vremensko-prostornih parametara, staničnih događanja (proliferacija, migracija, molekularna specifikacija, razvitak fenotipa, rast aksona, sinaptogeneza) koji se događaju u prolaznim histogenetskim odjeljcima i mogu se prikazati putem in vivo MR. Razvitak talamokortikalnih veza do somatosenzoričkog, cingularnog i prekunealnog korteksa i nucleus basalis bit će analiziran s pomakom imunoreaktivnosti na sinaptičke proteine od intraaksonalne reakcije preko SP do CP između 22 i 26 postkoncepcijskih tjedana. Istražit će se korelacija tog procesa s MR. Kao rezultat, očekujemo nova razvojna bodovanja usmjerena na neuronske veze i promjenjivu temeljnu arhitekturu fetalnog korteksa, osobito tijekom razdoblja prematuriteta. Novi višerazmjerni pristup od EM do MR temelji se na analizi postojećih uzoraka Zagrebačke neuroembriološke zbirke i razvojne baze MR podataka i važan je da se premosti znanje o razvitku humanog konektoma i ekspresije genskih putanja na jednoj strani te nedostatnih podataka o uključenosti sinapsi na drugoj strani. Novo razvojno bodovanje normotipičnih prematurusa koristit će naši klinički partnerima longitudinalno praćenje skupina djece, koja su obuhvaćena prethodnim HRZZ projektima. Implementacija novog razvojnog bodovanja pomoći će u bitnom razlikovanju organizacije mozga u ranim i kasnim skupinama prematurusa i pomoći u rasvjetljavanju uzroka, ranoj dijagnozi i ciljanom habilitacijskom tretmanu neurorazvojnih  poremećaja. ]]></summary_hr><summary_en><![CDATA[Main goal is the synthesis and integration of spatio-temporal indicators of histogenetic events in transient laminar brain compartments on multilevel resolution scales (from nanoscale EM to macroscale on MR) and bring these parameters into a spatial relationship with thalamocortical neuronal connectivity distribution: synapses, presynaptic axons and postsynaptic elements in SP (subplate), CP (cortical plate) and MZ (marginal zone). These goals are connected through spatio-temporal parameters, cellular events (proliferation, migration, molecular specification, phenotype development, axon growth, synaptogenesis) that occur in transient histogenetic compartments and can be shown by in vivo MR. Development of thalamocortical connections to the somatosensory, cingulate and precuneal cortex and the nucleus basalis will be analyzed with shift of immunoreactivity of synaptic proteins from intra-axonal reaction via SP to CP between 22 and 26 postconceptional weeks.Correlation of this process with MR will be investigated. As a result, we anticipate new developmental scoring targeting neural connections and changing underlying architecture of fetal cortex, particularly during period of prematurity. New multiscale approach from EM to MR is based on analysis of existing samples of the Zagreb Neuroembryological Collection and developmental MR database and is important to bridge the knowledge about development of human connectome and gene pathway expression on the one hand and insufficient data on involvement of synapses on the other. The new developmental scoring of normotypical premature infants will be used by clinical partners for longitudinal monitoring of groups of children, which were included in previous CSF projects. Implementation of new developmental scoring will help significantly in differentiating organization of brain in early and late preterm infants and help in elucidating causes, early diagnosis and targeted habilitation treatment of neurodevelopmental disorders.]]></summary_en></project><project>
<id>17865</id><title_hr><![CDATA[Innovative Water Retention for Climate Change Mitigation, Sustainable Agriculture and Flood Protection]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5844</user_id><user_firstLast_name>Tamara Marković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-2429</code><acronim><![CDATA[]]></acronim><duration>01.12.2025 - 30.11.2030</duration><status>U tijeku</status><financ_value>60,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Rudarstvo, nafta i geološko inženjerstvo, </scie_field_hr><scie_field_en>Mining, petroleum and geological engineering, </scie_field_en><institution_hr><![CDATA[Hrvatski geološki institut]]></institution_hr><institution_en><![CDATA[Croatian Geological Survey]]></institution_en><team_members_id>872965</team_members_id><team_members_names><![CDATA[ Doktorand: Ivana Benčić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>17870</id><title_hr><![CDATA[Razvoj modela potresnog rizika škola u Republici Hrvatskoj]]></title_hr><title_en><![CDATA[Development of an Earthquake Risk Model for Schools in the Republic of Croatia]]></title_en><user_id>12891</user_id><user_firstLast_name>Marta Šavor Novak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2025-02</proposal_call><code>UIP-2025-02-3985</code><acronim><![CDATA[EARS]]></acronim><duration>01.04.2026 - 31.03.2031</duration><status>U tijeku</status><financ_value>239.970,75 eur</financ_value><scie_area_hr>Tehničke znanosti, Prirodne znanosti, Interdiciplinarne znanosti, </scie_area_hr><scie_area_en>Technological sciences, Natural sciences, Interdisciplinary scientific area, </scie_area_en><scie_field_hr>Građevinarstvo, Geofizika, Temeljne tehničke znanosti, </scie_field_hr><scie_field_en>Civil engineering, Geophysics, Basic engineering sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Građevinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Civil Engineering]]></institution_en><team_members_id>866676, 29584, 208, </team_members_id><team_members_names><![CDATA[Maja Baniček, Marina Frančić Smrkić, Iva Dasović, ]]></team_members_names><keywords_hr><![CDATA[potresni rizik, škole, potresna opasnost, izloženost, oštetljivost, prioritizacija, GIS]]></keywords_hr><keywords_en><![CDATA[earthquake risk, schools, seismic hazard, exposure, vulnerability, prioritisation, GIS ]]></keywords_en><summary_hr><![CDATA[Škole predstavljaju kritičnu infrastrukturu svake zajednice i njihova sigurnost i otpornost na djelovanje potresa mora biti svačiji prioritet. Nakon potresa koji su zadesili središnju Hrvatsku u 2020. godini, postalo je razvidno da škole u tom dijelu Republike Hrvatske nisu sigurna mjesta i da se pod hitno treba pristupiti izradi strategije obnove školskih zgrada. Kako se velik dio Republike Hrvatske nalazi u seizmički aktivnom području, od naročitog interesa je pouzdani model potresnog rizika škola kako bi se mogla odrediti ugroženost svih zgrada, a time i djece koja ih pohađaju, te prioritizirati zgrade za pojačanje i obnovu u kratkoročnom i dugoročnom okviru. Osnovni cilj projekta je stvaranje mlade istraživačke grupe u području potresnog inženjerstva koja će kreirati takav model potresnog rizika s fokusom na osnovne škole u Republici Hrvatskoj u obliku napredne web platforme, napraviti procjenu rizika i prioritizaciju, te koja će stvaranjem novih znanja u konačnici moći doprinijeti podizanju kapaciteta u borbi protiv potresa. Projektom se predviđa velik broj usavršavanja u međunarodno prepoznatim istraživačkim centrima koji se bave tom tematikom, te se planira uspostaviti dugoročna suradnja s vrhunskim svjetskim znanstvenicima iz područja. Osim velike znanstvene  vrijednosti, ovaj projekt ima neupitnu vrijednost za cijelo društvo.]]></summary_hr><summary_en><![CDATA[Schools are the critical infrastructure for any community and their safety and resilience to earthquakes must be a priority for everyone. After the earthquakes in central Croatia in 2020, it became clear that schools in this part of the country are not safe places and that there is an urgent need to develop a strategy for retrofitting school buildings. As a significant part of Croatia is located in a seismically active region, a reliable earthquake risk model for schools is of particular interest in order to assess the risk of all school buildings and consequently the risk to the children who attend them. This model will also make it possible to prioritize the seismic retrofitting of buildings, both in the short and long term. The main goal of the project is to establish a young research group in the field of earthquake engineering. This group will create such an earthquake risk model in the form of an advanced web platform, focusing on elementary schools in Croatia, perform risk assessment and prioritization, and contribute to increasing capacities in the fight against earthquakes by creating new knowledge. The project foresees a large number of trainings in internationally recognized research centers dealing with this topic and aims to establish long-term cooperation with world-leading researchers. In addition to its high scientific value, the importance of the project for society as a whole is undeniable.]]></summary_en></project><project>
<id>17873</id><title_hr><![CDATA[Razvoj materijala i poluvodičkih elemenata temeljen na boru za detekciju i emisiju svjetlosti u integriranoj fotonici]]></title_hr><title_en><![CDATA[Boron-enabled advancements in materials and device technologies for sensing and light emission in integrated photonics]]></title_en><user_id>6083</user_id><user_firstLast_name>Tihomir Knežević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-9996</code><acronim><![CDATA[BeamLight]]></acronim><duration>30.01.2026 - 29.01.2029</duration><status>U tijeku</status><financ_value>199.475,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>48, 25717, 6955, </team_members_id><team_members_names><![CDATA[Ivana Capan, Robert Bernat, Tomislav Suligoj, ]]></team_members_names><keywords_hr><![CDATA[depozicija bora, silicij karbid, emisija pojedinačnih fotona, lavinske diode za pojedinačne fotone, infracrveno zračenje, fotonika, optoelektronika]]></keywords_hr><keywords_en><![CDATA[boron deposition, silicon carbide, single-photon emission, single-photon avalanche diodes, near-infrared, photonics, optoelectronics]]></keywords_en><summary_hr><![CDATA[Područja fizike visokih energija, svemirskih i kvantnih tehnologija još uvijek trebaju iskoristiti puni potencijal fotonike koji teži zamjeni elektrona svjetlošću kako bi se postigle bolje performanse, manja potrošnja i brža obrada podataka. Istražuju se novi fotonički elementi s iznimnom otpornošću, svestranošću i osjetljivošću, uz mogućnosti jednostavne integracije. U tom kontekstu, pouzdane platforme poput silicija i silicijevog karbida ključne su za unaprjeđenje fotoničkih tehnologija putem primjene novih materijala, modifikacije materijala inženjeringom defekata i inovativnih mogućnosti integracije. Depozicija nanometarski tankih slojeva bora dovela je do razvoja poluvodičkih elemenata s iznimnim električnim i optičkim svojstvima te izvanrednom otpornošću. Razvoj nove metode depozicije slojeva bora putem magnetronskog rasprašivanja na siliciju i silicijevom karbidu otvara nove mogućnosti za izradu fotodioda. Na silicijevom karbidu, amorfni sloj bora koristit će se za formiranje p-tip područja bez dopiranja i realizaciju SiC dioda. SiC diode s pn-spojem nude iznimnu svestranost te se mogu koristiti kao električki pobuđeni izvori pojedinačnih fotona. Inženjering defekata u SiC istražit će se zbog njegovog potencijala za stvaranje učinkovitih izvora pojedinačnih fotona, koji imaju ključnu ulogu u razvoju kvantnih komunikacijskih mreža i fotonike na infracrvenim valnim duljinama. Korištenjem novih materijala poput nanočestica s mogućnošću pretvorbe infracrvene svjetlosti u vidljivu te njihovom integracijom s lavinskim diodama, omogućit će se razvoj infracrvenih senzora na silicijskoj platformi. Ovaj projekt ima za cilj dodatno unaprijediti senzore i elemente za svjetlosnu emisiju kroz istraživanje (i) tehnologije depozicije bora na siliciju i silicijevom karbidu, (ii) inženjeringa defekata u silicijevom karbidu za omogućavanje emisije pojedinačnih fotona te (iii) detekcije infracrvene svjetlosti pomoću silicijskih lavinskih dioda za detekciju pojedinačnih fotona.]]></summary_hr><summary_en><![CDATA[The fields of high-energy physics, space, and quantum technologies still must unlock the full potential of photonics and push toward replacing electrons with light for higher performance, lower consumption, and faster data processing. Novel photonics components with exceptional robustness, versatility, and sensitivity together with seamless integration possibilities are sought after. Established platforms such as silicon and silicon carbide are therefore essential for advancing photonic technologies through utilization of novel materials, materials modification through defect engineering and innovative device integration possibilities. The deposition of nanometer-thin layers of boron has resulted in semiconductor devices that have exceptional electrical and optical properties with remarkable robustness. The development of novel sputtered boron layer depositions on silicon and silicon carbide substrates opens new avenues for photodiode fabrication. On silicon carbide, amorphous boron layer will be used for dopingless p-type region formation and realization of pn-junction-like diodes. SiC pn-junction devices offer exceptional versatility that can be utilized as an electrically pumped single-photon light source. Defect engineering in SiC will be studied for its potential in creating efficient single-photon sources which hold promise for advancing quantum communication networks and photonics operating at near-infrared wavelengths. Furthermore, by using novel materials such as upconverting nanoparticles and integrating them with boron deposition technology on single-photon avalanche detectors, near-infrared sensors will be available on silicon platforms. This project aims to further advance sensors and light-emitting devices through research in (i) boron deposition technology on silicon and silicon carbide, (ii) silicon carbide defect engineering for enabling single-photon light emission, and (iii) near-infrared light detection on silicon single-photon avalanche diodes. ]]></summary_en></project><project>
<id>17886</id><title_hr><![CDATA[Otkrivanje poveznica između peripartalnog mentalnog i metaboličkog zdravlja putem metabolomičkih i genetičkih analiza]]></title_hr><title_en><![CDATA[]]></title_en><user_id>519</user_id><user_firstLast_name>Jasminka Štefulj</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-6650</code><acronim><![CDATA[LinkMe]]></acronim><duration>22.01.2026 - 21.01.2031</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>873065</team_members_id><team_members_names><![CDATA[ Doktorand: Marta Kaloper ]]></team_members_names><keywords_hr><![CDATA[trudnoća, gestacijski dijabetes, peripartalno mentalno zdravlje, metabolomika, polimorfizmi, serotonin, posteljica, masno tkivo]]></keywords_hr><keywords_en><![CDATA[pregnancy, gestational diabetes mellitus, peripartum mental health, metabolomics, polymorphisms, serotonin, placenta, adipose tissue]]></keywords_en><summary_hr><![CDATA[Sve je više dokaza o povezanosti metaboličkog i mentalnog zdravlja tijekom peripartalnog razdoblja. Gestacijski dijabetes melitus (GDM), najčešći metabolički poremećaj u trudnica, rizični je čimbenik za razvoj simptoma peripartalne depresije i anksioznosti, i obrnuto, pojačani simptomi ovih psihičkih problema čimbenik su rizika za GDM. Oba su stanja neovisno, a još više u kombinaciji, povezana s povećanim rizikom od nepovoljnih ishoda i za majku i za dijete. Međutim, biološki mehanizmi u podlozi odnosa peripartalnog mentalnog i metaboličkog zdravlja slabo su poznati. Stoga LinkMe projekt ima za cilj doprinijeti boljem razumijevanju preklapajućih i diskriminirajućih bioloških korelata peripartalnog mentalnog i metaboličkog zdravlja provedbom neciljanih metabolomičkih analiza, analizom polimorfizma gena kandidata i procjenom serotoninski parametara u krvi. Putem neciljanih metabolomičkih analiza uzoraka plazme trudnica, cilj nam je identificirati metabolite i metaboličke putove povezane s GDM-om kao i sa simptomima peripartalne depresije i anksioznosti u žena s normalnom tolerancijom glukoze i GDM-om. Putem komplementarnih neciljanih metabolomičkih analiza uzoraka plazme pupkovine, cilj nam je identificirati metaboličke putove koji su pod utjecajem metaboličkog i mentalnog zdravlja majke, unapređujući tako razumijevanje razvojnog porijekla zdravlja i bolesti. Paralelno, analizirat ćemo ekspresiju odabranih gena u relevantnim metaboličkim tkivima koja reguliraju fiziologiju majke tijekom trudnoće, posteljici i masnom tkivu. Analize genskih polimorfizama usredotočit će se na gene serotoninskog puta i kandidate iz dostupne literature. Predložene studije poboljšat će naše razumijevanje bioloških osnova peripartalnog metaboličkog i mentalnog zdravlja i mogu imati implikacije za kliničku praksu u budućnosti.]]></summary_hr><summary_en><![CDATA[There is increasing evidence of a link between metabolic and mental health during the peripartum period. Gestational diabetes mellitus (GDM), the most common metabolic disorder in pregnant women, is a risk factor for the development of peripartum depression and anxiety symptoms, and conversely, increased symptoms of these mental health problems are a risk factor for GDM. Both conditions are independently and even more so in combination associated with an increased risk of adverse outcomes for both mother and child. However, the biological mechanisms underlying the relationship between peripartum mental and metabolic health are poorly understood. Therefore, the LinkMe project aims to contribute to a better understanding of the overlapping and discriminative biological correlates of peripartum mental and metabolic health by performing untargeted metabolomic analyses, assessing candidate gene polymorphism and evaluating blood serotonin parameters. Through untargeted metabolomic analyses of plasma samples from pregnant women, we aim to identify metabolites and metabolic pathways associated with both GDM as well as with symptoms of peripartum depression and anxiety in women with normal glucose tolerance and GDM. Through complementary untargeted metabolomic analyses of cord plasma samples, we aim to identify metabolic pathways that are influenced by maternal metabolic and mental health, advancing thus our understanding of the developmental origins of health and disease. In parallel, we will perform expression analyses of selected genes in relevant metabolic tissues that regulate maternal physiology during pregnancy, i. e. in the placenta and adipose tissue. The analyses of genetic polymorphisms will focus on serotonin pathway genes and candidates from the available literature. The proposed studies will improve our understanding of the biological basis of peripartum metabolic and mental health and may have implications for clinical practice in the future.]]></summary_en></project><project>
<id>17888</id><title_hr><![CDATA[Između atributivne i tehničke povijesti umjetnosti: monumentalna raspela u Hrvatskoj (13. - 16. stoljeće)]]></title_hr><title_en><![CDATA[Between connoisseurship and technical art history: monumental crucifixes in Croatia (13th – 16th centuries)]]></title_en><user_id>5555</user_id><user_firstLast_name>Matko Matija Marušić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2025-02</proposal_call><code>UIP-2025-02-6234</code><acronim><![CDATA[Crux magna]]></acronim><duration>01.04.2026 - 31.03.2031</duration><status>U tijeku</status><financ_value>224.035,00 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Povijest umjetnosti, Znanost o umjetnosti, </scie_field_hr><scie_field_en>Art history, Arts, </scie_field_en><institution_hr><![CDATA[Institut za povijest umjetnosti]]></institution_hr><institution_en><![CDATA[Institute of Art History, Zagreb]]></institution_en><team_members_id>1088, 870507, 870523, 870505, </team_members_id><team_members_names><![CDATA[Danijel Ciković, Đurđina Lakošeljac, Valentina Baradel, Žana Matulić Bilač, ]]></team_members_names><keywords_hr><![CDATA[monumentalno raspelo, sakralna umjetnost, ikonografija, tehnička ispitavanja, srednji vijek, renesansa]]></keywords_hr><keywords_en><![CDATA[monumental crucifixes, sacral art, iconography, conservation-restoration research, Middle Ages, Renaissance]]></keywords_en><summary_hr><![CDATA[Projekt Crux magna istražuje korpus slikanih i rezbarenih monumentalnih raspela, izrađenih između 13. i 16. stoljeća. Bibliografskim, terenskim i arhivskim istraživanjem formirat će se cjeloviti korpus raspela (otprilike 100 primjeraka), što će omogućiti obuhvatno istraživanje njihove društvene, osjetilne, iskustvene i značenjske polivalentnosti. Projekt, u kojem sudjeluju istraživači u ranoj fazi karijere, počiva na premisi da se nova znanja mogu generirati isključivo interdisciplinarnim pristupom povjesničara umjetnosti i restauratora-konzervatora. Stoga se uz analizu stila, ikonografije, društvenih i povijesnih okolnosti nastanka raspela, predlaže njihovo usporedno sagledavanje s rezultatima tehničkih istraživanja, poput ispitivanja vrste i starosti drva, vrste pigmenta oslika, povijesti mijenjanja slikane opne i općenito transformacija kroz vrijeme. Predloženim pristupom – „između atribucijske i tehničke povijesti umjetnosti“ – projekt će doprinijeti prevladavanju jaza između tradicionalnog shvaćanja disciplina koje proučavaju i tumače umjetničku baštinu, što u stanovitoj mjeri još uvijek dominira istraživačkim tokovima stare sakralne umjetnosti. Kroz četiri istraživačke radionice, međunarodni skup, deset izlaganja na konferencijama, jednu monografiju i opsežan kritički katalog raspela, generirat će se nova znanja koja nisu relevantna isključivo za daljnja istraživanja, već i za konkretniju društvenu valorizaciju i obnovu nekih od najstarijih sačuvanih umjetnina u drvu u Hrvatskoj.]]></summary_hr><summary_en><![CDATA[The Crux magna project explores a corpus of painted and carved monumental crucifixes made between the 13th and 16th centuries in Croatia. A complete corpus of crucifixes will be formed through bibliographic, field, and archival research, including approximately 100 examples. This will enable comprehensive research of their social, sensory, and experiential polyvalence. The project is based on the premise that new knowledge can be generated exclusively through an interdisciplinary approach of art historians and restorers-conservators. Therefore, in addition to analysing the style, iconography, and social and historical circumstances of the creation of crucifixes, it is proposed that these research topics be addressed in conjunction with the findings of technical research. These include, among others, examining the type and age of wood, the type of painting pigment, the history of changing the painted layers and, in general, transformation over time. With the proposed approach – &#39;&#39;between connoisseurship and technical history of art&#39;&#39; – the project will contribute to overcoming the gap between the conventional understanding of the disciplines that study and interpret the artistic heritage, which to a certain extent still dominates the research currents of sacred art. Through four research workshops, an international conference, ten presentations at conferences, one monograph and an extensive critical catalogue of crucifixes, new knowledge will be generated that is not only relevant for further research but also for a more tangible social valorisation and restoration of some of the oldest preserved works of art made of wood in Croatia.]]></summary_en></project><project>
<id>17890</id><title_hr><![CDATA[Energy Harvesting for Internet of Underwater Things (GROTTOES); WP1 - Energy harvesting from Ambient Noise]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3404</user_id><user_firstLast_name>Kristian Jambrošić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-4050</code><acronim><![CDATA[]]></acronim><duration>03.11.2025 - 02.11.2031</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>872894</team_members_id><team_members_names><![CDATA[ Doktorand: Ivan Ucović ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>17892</id><title_hr><![CDATA[Primjena spektroskopije elektronske paramagnetske rezonancije u istraživanju ferocenoil-nukleobaznih konjugata]]></title_hr><title_en><![CDATA[Application of electron paramagnetic resonance spectroscopy in the study of ferrocenoyl-nucleobase conjugates]]></title_en><user_id>3176</user_id><user_firstLast_name>Jiangyang You</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-8382</code><acronim><![CDATA[AEPRFCNC]]></acronim><duration>19.01.2026 - 18.01.2029</duration><status>U tijeku</status><financ_value>190.224,85 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Interdisciplinarne prirodne znanosti, Fizika, Kemija, </scie_field_hr><scie_field_en>Interdisciplinary natural sciences, Physics, Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>2708, 13603, 2509, 2512, 29275, 5594, 4009, </team_members_id><team_members_names><![CDATA[Mario Basletić, Erim Bešić, Senka Djaković, Jasmina Lapić, Viktor Pilepić, Valerije Vrček, Tin Weitner, ]]></team_members_names><keywords_hr><![CDATA[organometalni kompleksi, ferocen, redoks reakcije, reaktivni kisikovi oblici, spektroskopija elektronske paramagnetske rezonancije, računalna kemija]]></keywords_hr><keywords_en><![CDATA[organometallic complexes, ferrocene, redox reactions, reactive oxygen species, electron paramagnetic resonance spectroscopy,, computational chemistry]]></keywords_en><summary_hr><![CDATA[Ferocenil-nukleobaze su konjugati s ferocenom i podjedinice nukleobaze kovalentno vezane odgovarajućim mostovima. Kemijska stabilnost ferocena omogućuje njegovu ugradnju u biomolekule poput nukleobaza. Kombinacija ovih dviju podjedinica spaja elektrokemijske i biokemijske aktivnosti u jednu molekulu. Ova svojstva izazvala su veliki interes za razvoj, sintezu i proučavanje ferocenoil-nukleobaznih konjugata radi njihove moguće biokemijske i farmaceutske primjene. Budući da mnoge potencijalne primjene ferocenil-nukleobaza uključuju reverzibilnu jednoelektronsku oksidaciju ferocenskih skupina, njihova bi analiza trebala uključivati dijamagnetski ferocen kao i njegov paramagnetski derivat ferocenij.Stoga će se u ovom projektu primijeniti spektroskopija elektronske paramagnetske rezonancije (EPR) u rasponu od sobne temperature do ~4 K, elektrokemijske metode, laserska spektroskopija, spektroskopija nuklearne magnetske rezonancije (NMR) te metode računalne kemije kako bismo pružili detaljnu analizu različitih novosintetiziranih mono- i bis-ferocenil-nukleobaza s karbonilnom skupinom kao premosnicom (ferocenoil-nukleobazni konjugati). EPR će pružiti detaljnu analizu ferocenija u širokom rasponu temperatura te nadopuniti rezultate dobivene na višim temperaturama uporabom optičke spektroskopije, NMR spektroskopije i cikličke voltametrije. Eksperimentalno dobiveni rezultati uspoređivat će se s računalnim rezultatima kako bi se nedvojbeno potvrdila točnost i pouzdanost dobivenih eksperimentalnih rezultata.Očekujemo da će ovaj projekt značajno produbiti uvid u strukturna i redoks svojstva konjugata ferocenoil-nukleobaza, kao i u magnetska svojstva ferocenskih kationa, što bi u konačnici uveliko pomoglo osmišljavanju primjene ovih spojeva. Također, u sklopu ovog projekta planira se unaprjeđenje EPR spektroskopske tehnike u proučavanju organometalnih kompleksa, što će biti od koristi sličnim istraživanjima tijekom i nakon završetka projekta.]]></summary_hr><summary_en><![CDATA[Ferrocenyl-nucleobase conjugates include ferrocene and nucleobase subunits that are covalently connected by different bridges. The chemical stability of ferrocene allows its incorporation into biomolecules such as nucleobases. The combination of these two subunits brings both electrochemical and biochemical activities into one molecule. These properties have sparked great interest in the development, synthesis and study of ferrocenyl-nucleobase conjugates for their possible biochemical and pharmaceutical applications.Since many potential applications of ferrocenyl nucleobases involve the reversible one-electron oxidation of ferrocene groups, their characterization should include diamagnetic ferrocene as well as its paramagnetic derivative ferrocenium. In this project we will apply electron paramagnetic resonance (EPR) spectroscopy from room temperature to ~4 K and electrochemical, spectroscopic and computational chemistry methods to provide detailed characterization of various newly synthesized mono- and bis-ferrocenyl-nucleobases with carbonyl groups as a linker (ferrocenoyl-nucleobases conjugates).  EPR will provide detailed analysis of ferroceniums over wide temperature ranges and complement optical and nuclear magnetic resonance (NMR) spectroscopy and cyclic voltammetry at higher temperatures. Experimental results will be compared with computational results for the purpose of deeper insight into the issue.We expect that this project will significantly deepen the insight into the structural and redox properties of ferrocenoyl-nucleobase conjugates, as well as into the magnetic properties of ferrocenium cations, which would ultimately help greatly in the design of the application of these compounds. Also, as part of this project, it is planned to improve the EPR spectroscopic technique in the study of organometallic complexes, which will be useful for similar research during and after the completion of the project.]]></summary_en></project><project>
<id>17893</id><title_hr><![CDATA[Klinička učinkovitost laserskih protokola dezinfekcije u endodontskom liječenju i njihov utjecaj na kemijska i strukturna svojstva intrakanalnog dentina ]]></title_hr><title_en><![CDATA[Clinical effectiveness of laser assisted disinfection protocols in endodontic therapy and their influence on chemical and structural properties of intracanal dentin]]></title_en><user_id>11262</user_id><user_firstLast_name>Ivona Bago</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-2042</code><acronim><![CDATA[CLINENDOLASER]]></acronim><duration>05.12.2025 - 04.12.2028</duration><status>U tijeku</status><financ_value>162.670,00 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Dentalna medicina, Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Dental medicine, Clinical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Stomatološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Dentistry]]></institution_en><team_members_id>855347, 870048, 20122, 13021, 12334, 23310, 23298, 870475, 867734, 867724, 867723, 867507, 867722, 870051, </team_members_id><team_members_names><![CDATA[Gabrijela Kapetanović Petričević, Ivan Katalinić, Marko Katić, Ivica Anić, Dragana Gabrić , Valentina Rajić, Ivana Vidović Zdrilić, Gianluca Gambarini, Gianluca Plotino, Aleksandar Jakovljevic, Ivana Milanović, Tomislav Lauc, Domagoj Kunčić, Tanja Gović, ]]></team_members_names><keywords_hr><![CDATA[endodoncija, laser, ispiranje, dezinfekcija, mikroorganizmi, intrakanalni dentin]]></keywords_hr><keywords_en><![CDATA[endodontics, laser, irrigation, disinfection, microorganisms, intracanal dentin]]></keywords_en><summary_hr><![CDATA[Minimizacija rizika za nastanak perzistentne endodontske infekcije jedan je od glavnih izazova suvremene endodontske terapije. Ograničenja konvencionalnih protokola dezinfekcije usmjerila su ispitivanja prema razvoju aktivacijskih protokola ispiranja endodontskog prostora zuba. Laserski aktivirano ispiranje (LAI) temelji se na prijenosu energije erbij lasera u otopinu unutar korijenskog kanala uz stvaranje fotoakustičnih intrakanalnih kavitacija, koje uzrokuju dinamiku i strujanje irigansa kroz čitavi kanalni sustav zuba. Iako se ovom tehnikom, prema in vitro istraživanjima, postiže učinkovitije čišćenje korijenskog kanala zuba, još uvijek nemamo podataka o doprinosu LAI-a u kliničkim istraživanjima. Svrha projekta je ispitati kliničke prednosti laserske tehnologije u endodontskom liječenju kroz njegove primarne (cijeljenje periapikalne lezije, postoperativna bol) i sekundarne (antimikrobni učinak) ishode. Navedeno će biti ispitano kroz dva klinička randomizirana istraživanja, u kojima će biti korišteni protokoli ER:YAG LAI-a Super Short Pulse modaliteta i diodnog lasera, tijekom jednoposjetnog endodontskog liječenja zuba s apikalnim parodontitisom. U dugom dijelu projekta, ispitat će se ex vivo doprinos Er:YAG LAI-a u uklanjanju pulpnog tkiva iz kanala nakon minimalno invazivne obrade. U trećem dijelu projekta, ispitat će se učinak laserskog zračenja različitih valnih duljina i modaliteta rada na kemijska i strukturna svojstva intrakanalnog dentina i, posljedično, na svezu novih bioaktivnih kalcij-silikatnih materijala na takav dentin. Originalnost predloženog projekta je u interdisciplinarnom istraživanju laserske tehnologije u endodontskom liječenju, u kojem će se razjasniti klinički doprinos Er:YAG LAI i diodnog lasera, ali i mogući učinak laserske dezinfekcije na kvalitetu punjenja kanala novim kalcij-silikatnim punilima. Novim predloženim projektom želi se postići kontinuitet istraživanja u tom specifičnom području s obzirom na njegov klinički značaj.]]></summary_hr><summary_en><![CDATA[Minimizing the risk of developing persistent endodontic infection is one of the main challenges in endodontic therapy. The limitations of conventional disinfection protocols have directed studies towards the investigation of activated irrigation protocols. Laser-activated irrigation (LAI) is based on the transfer of erbium laser energy into the irrigant inside the root canal causing the development of phoacoustic intracanal cavitations, strong dynamics and flow of irrigant throughout the entire root canal system. Although this technique is highly effective in root canal cleaning in ex vivo studies, there is still no information about its contribution in clinical studies. The purpose of this project is to examine the clinical advantages of laser technology in endodontic therapy through its primary (healing of the periapical lesion, postoperative pain) and secondary outcomes (antimicrobial effect). The above will be examined through two clinical randomized studies, in which Er:YAG LAI Super Short Pulse modality and diode laser will be used, during single-visit endodontic treatment. In the second part of the project, the ex vivo contribution of Er:YAG LAI in the removal of pulp tissue from the root canal after minimally invasive  instrumentation will be investigated. In the third part, the effect of laser radiation of different wavelengths and modalities on the chemical and structural properties of intracanal dentin will be examined, and, consequently, on the bonding quality of new bioactive calcium-silicate materials. The originality of the project is in the interdisciplinary research of laser technology in endodontic therapy, which will clarify the clinical contribution of Er:YAG LAI and diode laser during a single-visit endodontic treatment, as well as the possible effect of the laser disinfection on the quality of calcium-silicate based root canal filling. This project aims to achieve continuity of research in that specific area considering its clinical impact.]]></summary_en></project><project>
<id>17894</id><title_hr><![CDATA[Jednostavne Simulacije Pobuđenih Stanja Uz Preklapanja Valnih Funkcija]]></title_hr><title_en><![CDATA[Easy Excited State Simulations Through Wave Function Overlaps]]></title_en><user_id>19680</user_id><user_firstLast_name>Marin Sapunar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2025-02</proposal_call><code>UIP-2025-02-6928</code><acronim><![CDATA[EasyWFO]]></acronim><duration>01.04.2026 - 31.03.2031</duration><status>U tijeku</status><financ_value>252.732,50 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>866630, </team_members_id><team_members_names><![CDATA[Antonio Prlj, ]]></team_members_names><keywords_hr><![CDATA[fotokemija, neadijabatska dinamika, pobuđena stanja, elektronska struktura, molekulske orbitale, dijabatska stanja]]></keywords_hr><keywords_en><![CDATA[photochemistry, nonadiabatic dynamics, excited states, electronic structure, molecular orbitals, diabatic states]]></keywords_en><summary_hr><![CDATA[Važnost simulacija neadijabatske dinamike za razumijevanje raznih procesa u pobuđenim elektronskim stanjima — u rasponu od fotoizomerizacije ili fotodegradacije do luminiscencije — već dugo je poznata. U ovom projektu poboljšat ćemo korisnost i proširiti primjenjivost metoda baziranih na preklapanjima valnih funkcija (WFO) u simulacijama neadijabatske dinamike i isporučiti paket za automatizaciju bitnih ali složenih zadataka. WFO su najizravnija, kvantitativna mjera promjena elektronskih valnih funkcija i koriste se tijekom istraživanja neadijabatske dinamike, od početnih zadataka odabira metode i uzorkovanja početnih uvjeta preko simulacija velikih razmjera do analize i interpretacije rezultata.Međutim, trenutne metode temeljene na WFO učinkovite su samo za sustave s manjim geometrijskim iskrivljenjima ili kratkim vremenima simulacije. Ovo ograničenje značajno smanjuje njihovu korisnost u stvarnim aplikacijama koje uključuju velike i fleksibilne molekule, gdje je potrebno primijeniti neizravnije mjere za usporedbu valnih funkcija. Projekt se bavi ovim izazovom istražujući četiri teme:(i) Implementacija transformacije orbitala koja minimizira učinke kretanja osnovnog skupa uz očuvanje informacija o promjeni oblika orbitala.(ii) Razvoj integriranog paketa temeljenog na WFO za simulacije pobuđenih stanja.(iii) Mjerenje rezultata metoda te stvaranje baza podataka.(iv) Primjena na procese u pobuđenim stanjima, pokazujući njihovu sposobnost objašnjavanja složenih reakcija.Ostvarivanjem ovih ciljeva, projekt može značajno utjecati na područje neadijabatske dinamike čineći dosad izazovne zadatke pristupačnijim.]]></summary_hr><summary_en><![CDATA[The importance of nonadiabatic dynamics simulations for understanding a variety of processes in excited electronic states — ranging from photoisomerization or photodegradation to luminescence — has long been recognized. In this project, we will enhance the utility and broaden the applicability of wave function overlap (WFO) methods in nonadiabatic dynamics simulations and deliver a user-friendly package to automate essential labor-intensive tasks. WFOs are the most direct, quantitative measure of changes in electronic wave functions and are used throughout nonadiabatic dynamics research, from the initial tasks of method selection and sampling initial conditions to large-scale simulations and result analysis and interpretation.However, current WFO-based methods are effective only for systems with minor geometric distortions or short simulation times. This limitation significantly reduces their usefulness in real-world applications involving large and flexible molecules, where more indirect measures for comparing wave functions need to be employed. The project addresses this challenge by investigating four topics:(i) Implementation of an orbital transformation method that minimizes basis set movement effects while preserving orbital deformation information.(ii) Development of an integrated WFO-based package for excited state simulations.(iii) Benchmarking and database creation.(iv) Application to excited state processes to demonstrate the method&#39;s capability in tackling complex reactions.By achieving these goals, the project aims to significantly impact the field of nonadiabatic dynamics by making previously challenging tasks more accessible.]]></summary_en></project><project>
<id>17903</id><title_hr><![CDATA[Razotkrivanje kontekstom uvjetovane složenosti supramolekularnih nanostruktura kratkih peptida]]></title_hr><title_en><![CDATA[Unravelling the Context-Dependent Complexity of Supramolecular Short-Peptide Assemblies]]></title_en><user_id>24626</user_id><user_firstLast_name>Daniela Kalafatovic</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-3357</code><acronim><![CDATA[Super DeShPet 2.0]]></acronim><duration>02.12.2025 - 01.12.2028</duration><status>U tijeku</status><financ_value>200.000,00 eur</financ_value><scie_area_hr>Prirodne znanosti, Tehničke znanosti, </scie_area_hr><scie_area_en>Natural sciences, Technological sciences, </scie_area_en><scie_field_hr>Kemija, Biologija, Računarstvo, Biotehnologija u biomedicini, </scie_field_hr><scie_field_en>Chemistry, Biology, Computer sciences, Biotechnology in Biomedicine, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Tehnički fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Engineering]]></institution_en><team_members_id>861667, 2658, 855605, 856300, 870190, 865282, 869795, 870181, </team_members_id><team_members_names><![CDATA[Toni Todorovski, Goran Mauša, Patrizia Janković, Erik Otović, Ivan Sasselli, Marko Babić, Ena Dražić, Marta De Zotti, ]]></team_members_names><keywords_hr><![CDATA[peptidi, samo-sastavljanje, supramolekularni sustavi, molekularna dinamika, generativna umjetna inteligencija]]></keywords_hr><keywords_en><![CDATA[peptides, self-assembly, supramolecular systems, molecular dynamics, generative artificial intelligence]]></keywords_en><summary_hr><![CDATA[SuPer DeShPet 2.0 ima za cilj unaprijediti otkrivanje i razumijevanje supramolekularnih peptidnih materijala spregom umjetne inteligencije (AI), simulacija molekularne dinamike (MD) i eksperimentalne validacije, temeljeći se na prethodno ostvarenim rezultatima iz UIP-2019-04-7999. Projekt će izučavati ključne izazove u istraživanju peptida, poput nedostatka integracije između ranije navedenih područja, neusklađenosti izvještavanja podataka i otežane ponovljivosti eksperimenata. Generativna umjetna inteligencija temeljena na neuronskim mrežama koristit će se za predlaganje peptidnih sekvenci s visokim potencijalom za samo-sastavljanje, koje će zatim biti validirane pomoću MD simulacija i eksperimentalne karakterizacije. Ovaj iterativni proces omogućit će usavršavanje AI modela koji će uz podatke o sekvenci uzimati u obzir i kontekst samo-sastavljanja. U području MD-a, koristiti će se grube simulacije (eng. coarse-grain) za bolje razumijevanje agregacije peptida i utjecaja parametara simulacija na njezin ishod. Rezultati simulacija usporediti će se s eksperimentalnim mjerenjima, poput cirkularnog dikroizma (CD), čime će se stvoriti povratna petlja koja će usavršiti i modele i simulacije. Eksperimentalno će se karakterizirati najperspektivniji peptidni kandidati, odabrani umjetnom inteligencijom i rafinirani molekularnom dinamikom, istražujući njihovo ponašanje u različitim uvjetima kako bi se razumio proces samo-sastavljanja i formiranja materijala. Končano, izraditi će se okvir za otkrivanje supramolekularnih peptidnih materijala, čime će se stručnjacima u području eksperimentalne kemije omogućiti pametno pretraživanje kemijskog prostora i održivi dizajn peptidnih materijala. Ovaj projekt dovesti će do novog znanja o odnosu između sekvence, eksperimentalnih uvjeta i samo-sastavljanja, unapređujući sposobnost predviđanja i kontrole agregacije peptida i pronalazak novih funkcionalnih materijala.]]></summary_hr><summary_en><![CDATA[SuPer DeShPet 2.0 aims to advance supramolecular peptide material discovery by integrating artificial intelligence (AI), molecular dynamics (MD) simulations, and experimental validation, building upon previous findings from UIP-2019-04-7999. Key challenges in peptide research, such as the lack of integration across these fields, data reporting inconsistencies, and difficulties in reproducibility, will be addressed. Generative AI based on neural networks will be used to propose peptide sequences with high self-assembly potential, which will undergo validation through MD simulations and experimental characterization. This iterative process will refine AI models to include assembly context alongside sequence data. In the MD domain, coarse-grain simulations will be employed to better understand peptide aggregation and the impact of simulation parameters on their outputs. These results will be cross-validated with experimental measurements, such as circular dichroism (CD), to create a feedback loop that refines both models and simulations. Experimentally, focus will be placed on characterizing the most promising peptide candidates identified by AI and further selected by MD, investigating their behavior in different environments and varying conditions to understand self-assembly and material formation. Ultimately, a framework will be established for discovering supramolecular peptide-based materials, providing experimentalists with smart exploration of the chemical space and more sustainable peptide material design. This project will generate new knowledge about the relationship among sequence, experimental context and self-assembly, advancing the ability to predict and control peptide aggregation and discovery of new functional materials.]]></summary_en></project><project>
<id>17908</id><title_hr><![CDATA[DONES]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4129</user_id><user_firstLast_name>Mario Rakić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-9060</code><acronim><![CDATA[]]></acronim><duration>01.05.2026 - 30.04.2031</duration><status>U tijeku</status><financ_value>60,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut za fiziku]]></institution_hr><institution_en><![CDATA[Institute of Physics in Zagreb]]></institution_en><team_members_id>873081</team_members_id><team_members_names><![CDATA[ Doktorand: Shubham Sharma ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>17910</id><title_hr><![CDATA[Aero- i hidrodinamičko poboljšanje ekološki prihvatljivih energetskih sustava]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4960</user_id><user_firstLast_name>Hrvoje Kozmar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-8469</code><acronim><![CDATA[AHEFES]]></acronim><duration>22.01.2026 - 21.01.2032</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, </scie_field_hr><scie_field_en>Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>873054</team_members_id><team_members_names><![CDATA[ Doktorand: Krunoslav Drašković ]]></team_members_names><keywords_hr><![CDATA[Mehanika fluida, aerodinamika, obnovljivi izvori energije, okoliš, prirodna ventilacija zgrade, aerodinamika aeroprofila]]></keywords_hr><keywords_en><![CDATA[Fluid mechanics, aerodynamics, renewable energy, environment, natural building ventilation, aerodynamics of airfoils]]></keywords_en><summary_hr><![CDATA[Predloženi projekt je usmjeren na tri teme vrlo relevantne za aerodinamičko i hidrodinamičko poboljšanje ekološki prihvatljivih energetskih sustava, tj. a) prirodnu ventilaciju zgrada, b) opterećenja okoliša na pučinske vjetroturbine, c) aerodinamički oblik lopatica vjetroturbina. Aktivnosti će se provoditi eksperimentalno u najsuvremenijim laboratorijima na a) Tehničkom sveučilištu u Grazu, Austrija, b) Sveučilištu Newcastle, UK, c) Tehničkom sveučilištu u Berlinu, Njemačka. Potrebna mjerna oprema postoji u ovim ustanovama i pokazala se prikladnom u prethodnim istraživanjima. Ciljevi su raspoređeni u tri radna paketa kako bi istražili a) učinak visoke zgrade i terminala zračne luke na prirodnu ventilaciju zgrade, b) učinak različitih vrsta valova na pučinske vjetroturbine, c) aerodinamičke značajke generatora vrtloga i Gurney zakrilca na aeroprofilima. Istraživačka grupa se sastoji od deset članova, mlađih i starijih istraživača iz Hrvatske i inozemstva, čime nudi jedinstven spoj prilagođen za postizanje zadanih ciljeva. Ukupan rezultat istraživanja je najmanje šest članaka u vodećim časopisima i šest konferencijskih radova. Rezultati će koristiti društvu i gospodarstvu s obzirom na dulji životni vijek pučinskih vjetroturbina. Poboljšana aerodinamika aeroprofila će omogućiti povećanje energije iskorištene iz vjetra i manje emisije CO2, čime će pogodovati okolišu. Nova saznanja oko prirodne ventilacije zgrada će omogućiti bolju ventilaciju unutarnjih prostora što će smanjiti potrebu za energijom stvorenom pomoću mehaničkih uređaja i poboljšati zdravlje ljudi u zatvorenim prostorima, što je posebno poželjno u trenutnoj pandemiji. Korisnici rezultata su u sektoru obnovljivih izvora energije, uključujući strojarstvo, građevinarstvo, i energetiku, uz zdravstvene stručnjake u epidemiologiji i toksikologiji, čime se nude jasne koristi za različite istraživačke zajednice i stručnjake iz prakse.]]></summary_hr><summary_en><![CDATA[The proposed project focuses on three topics highly relevant to aerodynamic and hydrodynamic enhancement of environmentally friendly energy systems, i.e. a) natural building ventilation, b) environmental loads on offshore wind turbines, c) aerodynamic design of wind-turbine blades. The activities will be performed experimentally in state-of-the art facilities at a) Graz University of Technology, Austria, b) Newcastle University, UK, c) Technical University of Berlin, Germany. The experimental technique is readily available in these facilities and proved suitable in previous studies. Research objectives are arranged in three work packages to respectively address a) the effect of a tall building and an airport terminal on the natural building ventilation, b) the effect of various waves’ types on offshore wind turbines, c) the aerodynamic performance of Vortex Generators and Gurney Flap on airfoils. The research group consists of ten members, junior and senior researchers from Croatia and abroad, thus offering a unique blend perfectly suited to achieve the intended goals. The total research output is at least six journal articles in leading journals and six conference contributions. The results will benefit the society and economy given the longer life of offshore wind turbines. The improved aerodynamics of airfoils will allow for more energy harnessed from the wind and less CO2 emissions, thus benefiting the environment. The natural building ventilation findings will allow for better ventilation of indoor spaces that will reduce the need for energy created using mechanical devices and enhance human health in indoor spaces, which is particularly desired in the current pandemic. The users of the results are in the renewable energy sector, including mechanical, civil, ocean, and energy engineering, in addition to health professionals in epidemiology and toxicology, thus offering clear benefits for various research communities and practicing experts.]]></summary_en></project><project>
<id>17912</id><title_hr><![CDATA[Deciphering the role of ER-mitochondria tethering protein PTPIP51 in microglial activation in frontotemporal dementia/amyotrophic lateral sclerosis]]></title_hr><title_en><![CDATA[]]></title_en><user_id>12500</user_id><user_firstLast_name>Andrea Markovinović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-7444</code><acronim><![CDATA[]]></acronim><duration>26.01.2026 - 25.01.2032</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Medicine]]></institution_en><team_members_id>873074</team_members_id><team_members_names><![CDATA[ Doktorand: Ivona Čargonja ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>17915</id><title_hr><![CDATA[Funkcionalni fotoreaktivni kromofori za primjene u organskoj sintezi i biologiji]]></title_hr><title_en><![CDATA[]]></title_en><user_id>376</user_id><user_firstLast_name>Nikola Basaric</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-7767</code><acronim><![CDATA[FunPhotoAppSynBio]]></acronim><duration>02.02.2026 - 01.02.2031</duration><status>U tijeku</status><financ_value>60,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>873017</team_members_id><team_members_names><![CDATA[ Doktorand: Karla Karadža ]]></team_members_names><keywords_hr><![CDATA[Fotokemija, Organska sinteza, Fotofizika, Fotokavezi, Fluorescentne boje, Foto-terapija karcinoma, BODIPY, Karbazoli, Bifenilamini]]></keywords_hr><keywords_en><![CDATA[Photochemistry, Organic synthesis, Photophysics, Photocages, Fluorescent dyes, Cancer photo-therapy, BODIPY, Carbazoles, Biphenylamines]]></keywords_en><summary_hr><![CDATA[Fotokemija je važno multidisciplinarno znanstveno područje na začelju istraživanja u kemiji, fizici i biologiji, s brojnim primjenama u modernim tehnologijama. Suština istraživanja u fotokemiji usmjerena je na razvoj novih funkcionalnih kromofora s različitim primjenama. U okviru predloženog projekta radit ćemo na tri kromofora, BODIPY, karbazolima i bifenilaminima, njihovoj sintezi i istraživanju fotofizičkih svojstava i fotokemijske reaktivnosti. Nadalje, pokušat ćemo pronaći primjenu ovih kromofora u organskoj sintezi i biologiji. BODIPY derivati su izvrsna fluorescentna bojila koja će se istraživati kako bi se razvile nove zaštitne skupine koje se uklanjaju u fotoreakcijama (fotokavezi) i unutarstanične fluorescentne boje ili prijenosnici lijekova. Derivati karbazola bit će pripravljeni s ciljem razvoja nove linije protutumorskih foto-terapeutika koji svoje djelovanje temelje na fotogeneriranju aza-kinon metida (aza-QM), a ne singletnog kisika. Nadalje, radit ćemo na objašnjenju reakcijskog mehanizma stvaranja aza-QM-a i njihovoj upotrebi u sintezi složenih aza-heterocikala. Derivati bifenilamina istraživat će se kao potencijalni fotokavezi koji apsorbiraju vidljivu svjetlost u dvofotonskoj apsorpciji i mogu se koristiti u biologiji. Uz fundamentalni karakter predloženog istraživanja, cilj nam je ići dalje od trenutnog stanja tehnike i tražiti primjene, ne samo u organskoj sintezi, već i u biomedicini, kroz razvoj novih foto-aktivirajućih lijekova ili novih fluorescentnih reagensa za bojenje organela u mikroskopiji. Predviđa se da će FunPhotoAppSynBio tim pronaći niz funkcionalnih kromofora s biološkim aktivnostima (hit molekule), koji će se dalje optimirati prema lead-molekulama. To će pomoći u razvoju novih fluorescentnih alata u dijagnostici i foto-liječenju raka s minimalnim nuspojavama, uz dobrobit za cijelo društvo.]]></summary_hr><summary_en><![CDATA[Photochemistry is an important multidisciplinary scientific field at the forefront of research in chemistry, physics and biology, with numerous applications in modern technologies. Quintessence of the research in photochemistry is focused on the development of new functional chromophores with different applications. Within the proposed project we will work on three chromophores, BODIPY, carbazoles and biphenylamines, their synthesis and investigation of the photophysical properties and photochemical reactivity. Furthermore, we will try to find the applications of these chromophores in organic synthesis and biology. The BODIPY derivatives are excellent fluorescent dyes which will be investigated to develop new photo-cleavable protective groups (photocages) and intracellular fluorescent labels or drug delivery vehicles. The carbazole derivatives will be made with the aim to develop new line of cancer photo-therapeutics that base their action on generation of aza-quinone methides (aza-QM), and not singlet oxygen. Furthermore, we will work on the elucidation of reaction mechanism of aza-QM generation and its use in the synthesis of complex aza-heterocycles. The biphenylamine derivatives will be investigated as potential two-photon absorbing photocages that absorb visible light and can be used in biology. In addition to the fundamental character of the proposed investigation, we aim to go beyond the state of the art and seek applications, not only in organic synthesis, but also in biomedicine, such as development of new photo-activable drugs or new fluorescent reagents for the staining of organelles in microscopy. It is anticipated that the FunPhotoAppSynBio team will find a number of functional chromophores with biological activities (hit molecules), which will be further improved towards lead molecules. This will help in the development of new fluorescent tools in diagnostics and photo-treatments for cancer with minimal side-effects, with benefits to the whole society.]]></summary_en></project><project>
<id>17916</id><title_hr><![CDATA[Generativna umjetna inteligencija u pravnom prevođenju]]></title_hr><title_en><![CDATA[Generative Artificial Intelligence in Legal Translation]]></title_en><user_id>7422</user_id><user_firstLast_name>Martina Bajčić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-3140</code><acronim><![CDATA[GenAI-LT]]></acronim><duration>05.12.2025 - 04.12.2028</duration><status>U tijeku</status><financ_value>145.551,14 eur</financ_value><scie_area_hr>Humanističke znanosti, Društvene znanosti, Tehničke znanosti, Interdiciplinarne znanosti, </scie_area_hr><scie_area_en>Humanities, Social sciences, Technological sciences, Interdisciplinary scientific area, </scie_area_en><scie_field_hr>Interdisciplinarne humanističke znanosti, Računarstvo, Pravo, Informacijske znanosti, Filologija, </scie_field_hr><scie_field_en>Interdisciplinary humanities, Computer sciences, Law, Information sciences, Philology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Pravni fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Law]]></institution_en><team_members_id>870448, 867165, 2966, 868363, 5762, </team_members_id><team_members_names><![CDATA[Slavko Žitnik, Giorgio Maria Di Nunzio, Bruno Nahod, Dejana Golenko, Adrijana Martinović, ]]></team_members_names><keywords_hr><![CDATA[pravna terminologija, obrada prirodnog jezika (NLP), veliki jezični modeli, pravno prevođenje, višejezičnost]]></keywords_hr><keywords_en><![CDATA[legal terminology, natural language processing (NLP), large language models, legal translation, multilingualism]]></keywords_en><summary_hr><![CDATA[Utjecaj umjetne inteligencije na međujezičnu komunikaciju nedvojbeno je značajan. Neuronski modeli dramatično su poboljšali kvalitetu strojnoga prevođenja te se neprestano razvijaju nove tehnologije i alati generativne umjetne inteligencije, kao što su veliki jezični modeli. Unatoč rastućem interesu i znanstvenika i šire javnosti za primjenu ovih alata, njihova upotreba u području pravnoga prevođenja slabo je istražena. S obzirom na trend nezabilježenog interesa za primjenom umjetne inteligencije s jedne strane, važnost područja pravnoga prevođenja i razumijevanja pravne terminologije za sve građane, ali i za budućnost europskih integracija i jedinstvenog tržišta s druge strane, nužna su empirijska istraživanja o njihovoj primjeni na prevođenje prava. Projektnim prijedlogom istražit će se stoga primjena generativne umjetne inteligencije u prevođenju pravnih tekstova objedinjavanjem suvremenih metoda i pristupa iz triju ključnih područja: automatiziranog pravnog prevođenja, korpusno-utemeljene terminologije i (pravnih) informacijskih znanosti (obrada prirodnog  jezika; pravna informacija). Primijenit će se tehnike i metode obrade prirodnog jezika kako bi se integriralo znanje iz domene prava s jezičnim modelima te će se istražiti moguća unaprjeđenja modela u pogledu na terminologiju. Navedene metode i pristupi prilagodit će se obilježjima područja prava EU-a. Iskorak u odnosu na oskudna dosadašnja istraživanja čini ispitivanje uspješnosti jezičnih modela na različitim vrstama pravnih tekstova (uključujući digitalne pravne sadržaje) i na različitim službenim jezicima EU-a.]]></summary_hr><summary_en><![CDATA[The impact of artificial intelligence on interlingual communication is indisputably significant. Neural models have dramatically improved the quality of machine translation, while new generative AI (GAI) technologies and tools, such as large language models, are emerging. Despite the growing interest of both researchers and the general public in the application of these tools, their use in the field of legal translation is underresearched. Considering the unprecedented interest in the application of GAI on the one hand, and the importance of legal translation and understanding legal terminology for all citizens, as well as for the future of European integration and the single market on the other hand, it is instrumental to investigate the application of GAI to legal translation by virtue of empirical research. With this in mind, this proposal aims to explore the possibility of deploying GAI in the translation of legal texts by integrating contemporary methods and approaches from three key areas: automated legal translation, corpus-informed terminology, and (legal) information science (natural language processing; legal information). Computational techniques will be applied to integrate domain knowledge with language models, and to introduce enhancements to the models with an eye to legal terminology. These methods and approaches will be adapted to the characteristics of EU law. In contrast to the scarce existing research on this topic, this proposal aims to test the application of GAI on different types of legal texts (including digital legal content) and subfields of EU law in multiple EU languages.]]></summary_en></project><project>
<id>17923</id><title_hr><![CDATA[Otpornije projektiranje zidanih konstrukcija s duktilnim vezivima: razumijevanje dinamičkog ponašanja i seizmičkog odziva na više razina]]></title_hr><title_en><![CDATA[Resilient Engineering of Ductile Bonded Masonry: Understanding Dynamic Behavior and Seismic Response Across Scales]]></title_en><user_id>19011</user_id><user_firstLast_name>Nina Čeh</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2025-02</proposal_call><code>UIP-2025-02-2749</code><acronim><![CDATA[ResiBOND]]></acronim><duration>19.02.2026 - 18.02.2031</duration><status>U tijeku</status><financ_value>296.088,35 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Temeljne tehničke znanosti, Građevinarstvo, </scie_field_hr><scie_field_en>Basic engineering sciences, Civil engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Građevinski fakultet u Rijeci]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Civil Engineering]]></institution_en><team_members_id>868135, 867769, 866593, 871051, </team_members_id><team_members_names><![CDATA[Maria Lissner, Emina Hadžalić, Katarina Tutić, Marina Bagarić, ]]></team_members_names><keywords_hr><![CDATA[zidane konstrukcije s duktilnim vezivom, seizmički odziv, disipacija energije, veziva od adhezivnih pjena, višerazinska analiza, kontaktna mehanika]]></keywords_hr><keywords_en><![CDATA[ductile bonded masonry, seismic response, energy dissipation, adhesive foam binders, multi-scale analysis, contact mechanics]]></keywords_en><summary_hr><![CDATA[Zidane konstrukcije, naširoko korištene u građevinarstvu, su zbog krhke prirode tradicionalnog cementno-pješčanog morta izrazito osjetljive na seizmička djelovanja. Potresi u Hrvatskoj 2020. godine naglasili su hitnu potrebu za otpornijim rješenjima veziva kako bi se povećale duktilnost, disipacija energije i strukturalni integritet ziđa. Ovaj projekt istražuje poliuretanske adhezivne pjene kao alternativne vezivne materijale, iskorištavajući njihovu visoku duktilnost i svojstva prianjanja kroz inovativni pristup modeliranju i eksperimentalnoj validaciji na više razina.Ključni izazov u primjeni poliuretanskih pjena u zidanju je nedostatak verificiranih numeričkih modela koji točno opisuju njihovo ponašanje ovisno o brzini deformacije, svojstva prianjanja i seizmički odgovor. Ovaj projekt razvija sveobuhvatan numeričko-eksperimentalni okvir koji uključuje analizu na razini materijala kroz karakterizaciju ovisnosti o brzini deformacije i viskoelastičnih svojstava na Sveučilištu u Rijeci i Oxfordu, modeliranje na kontaktnoj razini putem naprednog modela kohezivne zone koji uključuje učinke perforacija, te validaciju na razini sustava kroz testiranje u stvarnoj veličini na seizmičkoj platformi L.E.D.A. laboratorija u Enni.Projekt će uspostaviti novu istraživačku skupinu na Sveučilištu u Rijeci, potičući razvoj mladih istraživača kroz zapošljavanje 2 poslijedoktoranda i 1 doktoranda. Suradnja s Oxfordom u testiranju pri visokim brzinama deformacije te s Wienerbergerom u industrijskoj primjeni osigurava interdisciplinarni i međusektorski utjecaj.Kombinirajući numeričko modeliranje i eksperimentalnu validaciju, istraživanje će definirati ključne mehaničke parametre, verificirati napredne kontaktne modele i procijeniti seizmičku otpornost ziđa s adhezivnim vezama. Rezultati će služiti građevinskim inženjerima, proizvođačima materijala i donositeljima odluka, doprinoseći seizmičkoj otpornosti, održivoj gradnji i budućoj standardizaciji duktilno vezanih zidanih konstrukcija.]]></summary_hr><summary_en><![CDATA[Masonry structures, widely used in civil engineering, remain highly vulnerable to seismic forces due to the brittle nature of traditional cement-sand mortar. The 2020 earthquakes in Croatia highlighted the urgent need for more resilient bonding solutions to enhance ductility, energy dissipation, and structural integrity of masonry. This project advances polyurethane adhesive foams as alternative binders, leveraging their high ductility and adhesion properties through an innovative modeling and experimental validation approach across scales.A key challenge in applying polyurethane foams in masonry is the lack of validated numerical models capturing their rate-dependent behavior, adhesion properties, and seismic response. This project develops a comprehensive numerical-experimental framework integrating material-scale analysis via rate-dependent and viscoelastic characterization at the University of Rijeka and Oxford, contact-scale modeling with an advanced cohesive zone model incorporating perforation effects, and assembly-scale validation through full-scale seismic tests at L.E.D.A. Laboratory in Enna.The project will establish a new research group at the University of Rijeka, fostering early-career researcher development with two postdoctoral researchers and a PhD student. Collaboration with Oxford in high-strain testing and Wienerberger for industry application ensures interdisciplinary and intersectoral impact.By combining numerical modeling and experimental validation, this research will define key mechanical parameters, validate advanced contact models, and assess the seismic performance of bonded masonry structures. The findings will support structural engineers, material manufacturers, and policymakers, contributing to seismic resilience, sustainable construction, and the future standardization of ductile bonded masonry technologies.]]></summary_en></project><project>
<id>17927</id><title_hr><![CDATA[DANube SEdiment Restoration: towards the deployment and upscaling of sustainable management of the sediments across the Danube catchment basin]]></title_hr><title_en><![CDATA[]]></title_en><user_id>22798</user_id><user_firstLast_name>Ivica Pavičić Pavičić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-9734</code><acronim><![CDATA[]]></acronim><duration>01.01.2026 - 31.12.2031</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Geologija, </scie_field_hr><scie_field_en>Geology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Rudarsko-geološko-naftni fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mining, Geology and Petroleum Engineering]]></institution_en><team_members_id>873004</team_members_id><team_members_names><![CDATA[ Doktorand: Roko Ramov ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>17928</id><title_hr><![CDATA[Neuronska kombinatorna optimizacija za predviđanje pogrešaka programske potpore]]></title_hr><title_en><![CDATA[Neural Combinatorial Optimization for Software Defect Prediction]]></title_en><user_id>12997</user_id><user_firstLast_name>Marin Šilić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-8486</code><acronim><![CDATA[NCOFSDP]]></acronim><duration>12.01.2026 - 11.01.2029</duration><status>U tijeku</status><financ_value>149.920,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>865837, 865838, 865840, 22589, 11194, 12993, 868422, 870527, </team_members_id><team_members_names><![CDATA[Helena Čeović, Ivan Mikulić, Marin Vlaić Vlaić, Adrian Satja Kurdija, Goran Delač, Klemo Vladimir, Stjepan Požgaj, Davor Vukadin, ]]></team_members_names><keywords_hr><![CDATA[Duboko učenje, Neuronska kombinatorna optimizacija, Neuronske mreže za grafove, Previđanje pogrešaka programske potpore, Značajke izvornog koda]]></keywords_hr><keywords_en><![CDATA[Deep learning, Neural combinatorial optimization, Graph neural networks, Software defect prediction, Source code features]]></keywords_en><summary_hr><![CDATA[Predviđanje pogrešaka programske potpore ključno je za poboljšanje kvalitete softvera i optimizaciju resursa za testiranje. Ovaj projekt istražuje inovativne pristupe predviđanju pogrešaka kroz dva glavna smjera: izvlačenje značajki temeljeno na neuronskom algoritamskom rezoniranju i neuronsku kombinatornu optimizaciju.Prvi smjer istraživanja fokusira se na unapređenje načina na koji izvlačimo značajke iz izvornog koda. Tradicionalne metode koriste metrike poput složenosti koda i povezanosti među modulima, dok noviji pristupi primjenjuju duboko učenje za analizu semantike koda. Naš pristup uvodi neuronsko algoritamsko rezoniranje - tehniku koja integrira klasične algoritme u neuronske mreže. Inspiriran uspješnom primjenom u drugim domenama, ovaj pristup ima potencijal značajno unaprijediti kvalitetu izvučenih značajki za predviđanje pogrešaka.Drugi smjer bavi se primjenom neuronske kombinatorne optimizacije na problem otkrivanja modula sklonih greškama. Ovaj pristup posebno je koristan kod traženja sličnih obrazaca grešaka u kodu, što se može modelirati kao problem izomorfizma podgrafova. Dok je ovaj problem tradicionalno težak za rješavanje, neuronska kombinatorna optimizacija nudi obećavajuću alternativu jer može učiti iz specifične distribucije problema u kontekstu programskog inženjerstva.Projekt ima potencijal unaprijediti postojeće metode predviđanja pogrešaka na dva načina: poboljšanjem kvalitete značajki koje opisuju kod i razvojem učinkovitijih algoritama za otkrivanje problematičnih dijelova koda. Uspješna implementacija ovih pristupa mogla bi značajno smanjiti troškove testiranja i održavanja softvera, istovremeno povećavajući njegovu pouzdanost. Projekt također otvara nove smjerove istraživanja u području programskog inženjerstva, posebno u kontekstu primjene neuronskih mreža na probleme kombinatorne optimizacije.]]></summary_hr><summary_en><![CDATA[Software defect prediction is crucial for improving software quality and optimizing testing resources. This project explores innovative approaches to defect prediction through two main directions: feature extraction based on neural algorithmic reasoning and neural combinatorial optimization.The first research direction focuses on advancing how we extract features from source code. Traditional methods use metrics such as code complexity and coupling between modules, while newer approaches apply deep learning to analyze code semantics. Our approach introduces neural algorithmic reasoning - a technique that integrates classical algorithms into neural networks. Inspired by successful applications in other domains, this approach has the potential to significantly enhance the quality of extracted features for defect prediction.The second direction deals with applying neural combinatorial optimization to the problem of detecting defect-prone modules. This approach is particularly useful when searching for similar error patterns in code, which can be modeled as a subgraph isomorphism problem. While this problem is traditionally difficult to solve, neural combinatorial optimization offers a promising alternative as it can learn from the specific distribution of problems in the context of software engineering.The project has the potential to advance existing defect prediction methods in two ways: by improving the quality of features that describe code and by developing more efficient algorithms for detecting problematic code sections. Successful implementation of these approaches could significantly reduce software testing and maintenance costs while increasing its reliability. The project also opens new research directions in software engineering, particularly in the context of applying neural networks to combinatorial optimization problems.]]></summary_en></project><project>
<id>17936</id><title_hr><![CDATA[Procjena fizioloških i agro-morfoloških svojstava hibrida pšenice]]></title_hr><title_en><![CDATA[Evaluation of physiological and agro-morphological traits in hybrid wheat]]></title_en><user_id>273</user_id><user_firstLast_name>Valentina Španić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-6559</code><acronim><![CDATA[Hybrowheat]]></acronim><duration>05.12.2025 - 04.12.2028</duration><status>U tijeku</status><financ_value>175.520,00 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Biotehnologija, Poljoprivreda, </scie_field_hr><scie_field_en>Biotechnology, Agriculture, </scie_field_en><institution_hr><![CDATA[Poljoprivredni institut Osijek]]></institution_hr><institution_en><![CDATA[Agricultural Institute Osijek]]></institution_en><team_members_id>865062, 865058, 7754, 22513, 2565, 21410, 20445, </team_members_id><team_members_names><![CDATA[Katarina Šunić, Jurica Duvnjak, Hrvoje Šarčević, Ivna Štolfa Čamagajevac, Rosemary Vuković, Goran Jukić, Ivan Varnica, ]]></team_members_names><keywords_hr><![CDATA[antioksidacijski metabolizam, agronomska svojstva, suša, Fusarium, hibridi, pšenica]]></keywords_hr><keywords_en><![CDATA[antioxidative metabolism, agronomical traits, drought, Fusarium, hybrids, wheat]]></keywords_en><summary_hr><![CDATA[Obzirom na porast populacije nužno je povećanje genetske dobiti pšenice. Jedna od mogućnosti je proizvodnja hibrida pšenice koji bi trebali imati povećanje uroda zrna i bolju kvalitetu. Prethodno projektu izabrale su se roditeljske linije prema sposobnosti oprašivanja i biologiji cvijeta, datumu klasanja i cvatnje, i visini biljaka kako bi se postigla sinkronizacija između majčinskih i očinskih komponenti. U projektu će novoformirani hibridi biti ispitani na agronomska i kvalitetna svojstva na dvije različite lokacije te heterozis, te opće i specifične kombinatorne sposobnosti roditelja. Kako bi hibridi trebali imati konkurentnu prednost, u usporedbi sa sortnim linijama pšenice u uvjetima stresa, istovremeno će se istraživani hibridi testirati u stakleniku u sušnom stresu tijekom cvatnje te stresu Fuzarijskom paleži klasa. Nadalje, između hibrida i njihovih roditeljskih linija razjasnit će se uloga antioksidacijskog metabolizma, fluoroscencije klorofila, stomatalne provodljivosti, te signalizacije apscizinske i salicilne kiseline u regulaciji odgovora na stres s naglaskom na tolerantnost na sušu. U stresu izazvanom Fuzarijskom paleži klasa ispitat će se molekularni odgovor povezano sa signalizacijom apzcisinske i salicilne kiseline. Jedan od općih ciljeva ovog projekta je ispitivanje sposobnosti hibrida koji će zahvaljujući novim tehnologijama i metodama ubrzati tolerantnost na stres, budući da klasični postupak dobivanja sorti pšenice traje 10-12 godina. Pomoću hibrida bi se zadovoljili zahtjevi za povećanjem uroda u kraćem periodu. Tijekom projekta diseminacija rezultata će se ostvariti kroz 7 konferencija, objavom najmanje 2 znanstvena rada indeksiranih u WoS-u, organizacijom radionice na Poljoprivrednom institutu Osijek, organizacijom istraživačke radionice za članove tima uz poziv inozemnog istraživača te usavršavanjem jednog člana tima.]]></summary_hr><summary_en><![CDATA[According to population growth, the wheat genetic gain should be increased. One of the solutions is the production of wheat hybrid varieties that should have increased yield and improved grain quality. Prior to project, parental lines according to pollination ability and floral biology, heading date, flowering date, and plant height were selected to obtain synchrony between maternal and paternal components. In the current project, newly formed hybrids will be tested for agronomical and quality traits at two different locations together with heterosis, and general and specific combining abilities of parents. As hybrids should have competitive advantage, compared to varietal wheat under stress, simultaneously, investigated hybrids will be tested in the greenhouse under non-lethal drought stress during anthesis and under Fusarium head blight stress. Further, the role of crosstalk between antioxidative metabolism, chlorophyll a flouroscence, stomatal conductance, abscisic and salicylic acid signaling in regulating stress response with emphasis on drought tolerance should be elucidated between hybrids and their parental lines. In stress induced by Fusarium head blight, the molecular response associated with abscisic and salicylic acid signalling will be also examined. One of the general aims of this project is to test hybrids abilities that will speed up stress tolerance due to novel technologies and methods, as classical procedure for obtaining wheat varieties is lasting 10-12 years. Hybrids would ensure the requirements for increased grain yield in shorter period. During project, dissemination of the results will be fullfiled through 7 conferences, by publication at least 2 scientific papers indexed in WoS, by organizing a workshop at the Osijek Agricultural Institute, and organization of a research workshop for team members with the invitation of a foreign researcher and the training of one team member.]]></summary_en></project><project>
<id>17940</id><title_hr><![CDATA[Mehanizmi lipotoksičnosti u akutnoj mijeloičnoj leukemiji]]></title_hr><title_en><![CDATA[Mechanisms of lipotoxicity in AML]]></title_en><user_id>4837</user_id><user_firstLast_name>Vilma Dembitz</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2025-02</proposal_call><code>UIP-2025-02-9477</code><acronim><![CDATA[LipoAML]]></acronim><duration>01.04.2026 - 31.03.2031</duration><status>U tijeku</status><financ_value>299.945,00 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>4676, 870537, 23838, 870751, 870793, </team_members_id><team_members_names><![CDATA[Hrvoje Lalić, Celine Philippe, David Čičić, Lara Divjak, Hannah Lawson, ]]></team_members_names><keywords_hr><![CDATA[akutna mijeloična leukemija, desaturacija masnih kiselina, lipotoksičnost, odgovor na nepravilno savijanje proteina, stanična smrt]]></keywords_hr><keywords_en><![CDATA[acute myeloid leukemia, fatty acid desaturation, lipotoxicity, unfolded protein response, cell death]]></keywords_en><summary_hr><![CDATA[Unatoč novim odobrenim terapijama za liječenje akutne mijeloične leukemije (AML) u posljednjem desetljeću, prognoza bolesti  i dalje je loša. To naglašava potrebu za identificiranjem novih molekularnih ciljeva. Promjene staničnog metabolizma značajka su maligne stanice i nude priliku za farmakološke intervencije zbog mogućnosti razvoja ciljanih enzimskih inhibitora. Naše prethodno istraživanje pokazalo je da je stearoil-CoA desaturaza (SCD) neovisni prognostički biljeg i metabolička ranjivost u AML-u. Inhibicija SCD-a (SCDi) dovodi do poremećaja ravnoteže zasićenih masnih kiselina (SFA) i mononezasićenih masnih kiselina (MUFA), no osnovni mehanizmi lipotoksičnosti koji izazivaju smrt leukemijskih stanica još uvijek nisu jasni. Preliminarni podaci sugeriraju da SCDi može utjecati na više putova, uključujući odgovor na nepravilno savijanje proteina (engl. unfolded protein response, UPR), ciklus aktivirane metilne skupine i sintezu sfingolipida, koji svi mogu doprinijeti staničnoj toksičnosti. Potencijalna poveznica između tih putova je promjena u omjeru NAD(P)+/NAD(P)H koja se javlja kao odgovor na SCDi. U ovom projektu cilj nam je istražiti ulogu UPR-a u lipotoksičnosti u odgovoru na SCDi, istražiti promjene u omjeru NAD(P)+/NAD(P)H i njegovu povezanost s indukcijom oštećenja DNA, ispitati aktivaciju ciklusa aktivirane metilne skupine nizvodno od poremećaja NAD(P)+/NAD(P)H i analizirati promjene u profilima sfingolipida u stanicama tretiranim SCDi i palmitatom. Ovi ciljevi pružit će uvid u potencijalne kombinacijske terapije koje uključuju SCDi. Nadalje, kako bismo povećali translacijski utjecaj naših nalaza, planiramo optimizirati uvjete u kulturi stanica i preciznije replicirati stanično i metaboličko okruženje u organizmu, uključujući razvoj 3D modela stanične kulture AML. Podaci iz in vitro istraživanja bit će uspoređeni s kliničkim odgovorom na terapije koje se koriste u praksi, kao i s rezultatima iz mišjih modela za spojeve koji su još uvijek u istraživanju.]]></summary_hr><summary_en><![CDATA[Despite the approval of several new therapies over the past decade, the prognosis for acute myeloid leukaemia (AML) remains poor, highlighting a significant need for the development of novel molecular targets. Rewiring of cellular metabolism has emerged as a hallmark of cancer, offering a promising avenue for pharmacological intervention due to its vulnerability to small molecule inhibitors. Our previous research identified stearoyl-CoA desaturase (SCD) as an independent prognostic marker and a potential targetable vulnerability in AML. Inhibition of SCD (SCDi) results in a disruption of the balance between saturated fatty acids (SFA) and monounsaturated fatty acids (MUFA), but the underlying mechanisms of lipotoxicity-induced cell death in leukemic cells remain unclear. Preliminary data suggest that SCDi may affect multiple pathways, including the unfolded protein response (UPR), one-carbon metabolism, and sphingolipid synthesis, all of which could contribute to leukemic cell toxicity. A potential link between these pathways is a shift in the NAD(P)+/NAD(P)H ratio, which occurs in response to SCDi. In this project, we aim to investigate the role of the UPR in SCDi-induced toxicity, explore changes in the NAD(P)+/NAD(P)H ratio and its connection to DNA damage, examine the activation of one-carbon metabolism downstream of NAD(P)+/NAD(P)H disturbances, and analyse alterations in sphingolipid profiles in SCDi and palmitate-treated cells. These objectives will provide insights into potential combination therapies involving SCDi. Furthermore, to enhance the translational impact of our findings, we plan to optimize in vitro cell culture conditions to more accurately replicate the cellular and metabolic environment observed in patients, including the development of 3D AML culture models. The in vitro data will be compared with clinical responses to therapies used in practice and with data from mouse models for investigational compounds.]]></summary_en></project><project>
<id>17941</id><title_hr><![CDATA[Digitalizacija u poduzetništvu u kontekstu odgovora na egzogeni šok: Pokretači, prepreke i utjecaj na otpornost poduzeća]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1287</user_id><user_firstLast_name>Marina Klačmer Čalopa</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-4011</code><acronim><![CDATA[DigEntre]]></acronim><duration>15.12.2025 - 14.12.2031</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, </scie_field_hr><scie_field_en>Economy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet organizacije i informatike]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Organization and Informatics]]></institution_en><team_members_id>870816</team_members_id><team_members_names><![CDATA[ Doktorand: Ana Novak ]]></team_members_names><keywords_hr><![CDATA[digitalizacija, digitalna transformacija, mala i srednja poduzeća, otpornost, ranjivost, COVID-19 kriza, Hrvatska]]></keywords_hr><keywords_en><![CDATA[digitalization, digital transformation, small and medium-sized companies, resilience, vulnerability, COVID-19 crisis, Croatia]]></keywords_en><summary_hr><![CDATA[Temeljna svrha istraživanja je dobiti odgovore na pitanja koji su se dijelovi hrvatske prerađivačke industrije i sektora trgovine i turizma pokazali najotpornijima odnosno najranjivijima tijekom krize COVID-19 i u čemu se ranjivost očituje. Specifični cilj projekta je ispitati jesu li i kako na otpornost poduzeća utjecale promjene u stupnju digitalizacije te koja su obilježja poduzeća koja su iskoristila krizu kao priliku kroz implementaciju digitalnih poslovnih modela, uvođenje novih kanala distribucije i razvoj proizvoda i usluga podržanih digitalnom tehnologijom. Šire, ispituje se koji faktori na razini industrije, poduzeća i poduzetnika u tri hrvatska sektora djeluju kao pokretači digitalizacije, a koji je obuzdavaju. Unutar odabranih djelatnosti fokus se usmjerava na mikro, mala i srednja hrvatska poduzeća kao najranjivije dijelove gospodarstva. Metodološki okvir za provedbu istraživanja uključuje longitudinalno kvantitativno istraživanje nad sekundarnim podacima za sedamnaestogodišnje razdoblje (2008-2024.), anketno istraživanje te kvalitativno istraživanje uz primjenu metode fenomenologije. Rezultati projekta reflektirat će se u objavi 13 radova u zbornicima međunarodno priznatih znanstvenih skupova te 8 A1 znanstvenih radova u časopisima indeksiranim u bazama WoSCC i/ili Scopus. Znanstveni doprinos projekta očituje se u razvijenom korpusu novog znanja o dihotomiji profila ranjivih i otpornih poduzeća. Također, obogatit će se još uvijek oskudno znanje o uzročno-posljedičnim vezama na relaciji digitalizacija - performanse poduzeća te će se doprinijeti izoštravanju spoznaja o pokretačima i preprekama digitalizacije. S aplikativnog aspekta znanje razvijeno u sklopu projekta bit će vrijedna baza za dizajniranje politika usmjerenih jačanju otpornosti poduzeća, te za unaprjeđenje i provedbu nacionalnog plana za digitalnu transformaciju gospodarstva, a sukladno naporima artikuliranim tzv. digitalnim kompasom digitalnog desetljeća EU-a.]]></summary_hr><summary_en><![CDATA[The basic purpose of the research is to get answers to the questions which parts of the Croatian manufacturing industry and the trade and tourism sectors have proven to be the most resilient or vulnerable during the COVID-19 crisis and in which vulnerability is manifested. The specific goal of the project is to examine whether and how changes in the degree of digitalization have affected the resilience and what are the characteristics of companies that used the crisis as an opportunity through the implementation of digital business models, the introduction of new distribution channels and the development of products and services supported by digital technology. Broadly, it examines which factors at the level of industry, companies and entrepreneurs in three Croatian sectors act as drivers of digitalization, and which restrain it. The focus is on micro, small and medium-sized Croatian companies as the most vulnerable parts of the economy. The methodological framework includes longitudinal quantitative research for the period 2008-2024, survey research and qualitative research. The project results are: publication of 13 papers in internationally scientific meetings proceedings and 8 A1 scientific papers in journals indexed in WoSCC and/or Scopus. The scientific contribution of the project is developed body of new knowledge about the dichotomy of the profile of vulnerable and resilient companies. Also, the still scarce knowledge about cause-and-effect relationships in relation to digitalization - company performance will be enriched and will contribute to sharpening knowledge about drivers and obstacles to digitalization. Applicative, the developed knowledge will be valuable for designing policies aimed at strengthening the resilience of companies, and for the improvement and implementation of the national plan for the digital transformation of the economy, and in accordance with the efforts articulated with the so-called digital compass of the EU&#39;s digital decade.]]></summary_en></project><project>
<id>17946</id><title_hr><![CDATA[Iterativne sredine – razvoji, analiza i primjene]]></title_hr><title_en><![CDATA[Iterative means – expansions, analysis and applications]]></title_en><user_id>2673</user_id><user_firstLast_name>Lenka Mihoković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2025-02</proposal_call><code>UIP-2025-02-8956</code><acronim><![CDATA[IS-RAP]]></acronim><duration>19.02.2026 - 18.02.2031</duration><status>U tijeku</status><financ_value>216.752,50 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>870595, 23106, </team_members_id><team_members_names><![CDATA[Toni Milas, Mate Puljiz, ]]></team_members_names><keywords_hr><![CDATA[Iterativne sredine, aproksimacije, asimptotski razvoji, verižni razlomci, specijalne funkcije, algoritmi]]></keywords_hr><keywords_en><![CDATA[Iterative means, approximations, asymptotic expansions, continued fractions, special functions, algorithms]]></keywords_en><summary_hr><![CDATA[Ovim projektom provodi se teorijsko istraživanje u području matematičke analize, usmjereno na sredine definirane različitim iterativnim postupcima. Takve se sredine nazivaju iterativne ili složene te se mogu opisati i funkcionalnim jednadžbama. Općenito ne mora postojati njihova zatvorena forma zbog čega je korisno dobiti i drugačije prikaze. Nastavno na prethodne rezultate vezane uz sredine, gdje su se asimptotski razvoji pokazali korisnima, posebice u slučajevima gdje nije poznat eksplicitni oblik ili je on dosta složen, sličan pristup primijenit će se i ovdje. Proučit će se općenitiji oblici razvoja u odnosu na već dobivene. Nadalje, promatrat će se i razvoji iterativnih sredina u obliku različitih tipova verižnih razlomaka čije se varijacije u zadnje vrijeme intenzivno proučavaju, te algoritmi pretvorbe iz jednog dobivenog oblika u drugi. Neki od rezltata bit će dani u obliku algoritama za računanje koeficijenata u promatranom razvoju što će omogućiti daljnju analizu i usporedbu dobivenih aproksimacija. Nove metode zajedno s dobivenim rezultatima generalizirat će se zatim u više smjerova od kojih valja spomenuti iterativne postupke za sredine više varijabli i pripadajuće razvoje i aproksimacije. Također, budući da je poznato kako su neke od iterativnih sredina povezane s hipergeometrijskim funkcijama, dobiveni se rezultati mogu razmotriti i u kontekstu teorije specijalnih funkcija.]]></summary_hr><summary_en><![CDATA[This project conducts theoretical research in the field of mathematical analysis, focused on means defined by various iterative procedures. Such means are called iterative or compound and can also be described by functional equations. In general, their closed form does not have to exist, which is why it is useful to obtain different representations. Continuing from previous results related to means, where asymptotic expansions have proven useful, especially in cases where the explicit form is not known or is quite complex, a similar approach will be applied here. More general forms of expansion will be studied in relation to those already obtained. Furthermore, expansions of iterative means in the form of different types of continued fractions whose variations have recently been intensively studied, as well as algorithms for converting from one obtained form to another, will be observed. Some of the results will be given in the form of algorithms for calculating coefficients in the corresponding expansion, which will enable further analysis and comparison of the obtained approximations. New methods together with the obtained results will then be generalized in several directions, one of which is the exploration of iterative procedures in many variables and the associated expansions and approximations. Also, since it is known that some of the iterative means are related to hypergeometric functions, the obtained results can also be considered in the context of the theory of special functions.]]></summary_en></project><project>
<id>17955</id><title_hr><![CDATA[Sinteza prirodnih aktivnih molekula i njihovih analoga u mili- i mikroprotočnim sustavima]]></title_hr><title_en><![CDATA[Synthesis of natural active molecules and their analogues in a milli- and microflow systems]]></title_en><user_id>428</user_id><user_firstLast_name>Anita Šalić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2025-02</proposal_call><code>UIP-2025-02-7561</code><acronim><![CDATA[NatSynFlow]]></acronim><duration>01.04.2026 - 31.03.2031</duration><status>U tijeku</status><financ_value>271.100,00 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Biotehnologija, Interdisciplinarne biotehničke znanosti, </scie_field_hr><scie_field_en>Biotechnology, Interdisciplinary biotechnical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet kemijskog inženjerstva i tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Chemical Engineering and Technology]]></institution_en><team_members_id>870456, 25646, 866028, 865027, </team_members_id><team_members_names><![CDATA[Anabela Ljubić, Filip Car, Milena Mlakić, Marijan-Pere Marković, ]]></team_members_names><keywords_hr><![CDATA[dimerizacija, biokataliza, mili- i  mikroprotočni uređaji, bioaktivne molekule, biotransformacija, kemijska sinteza ]]></keywords_hr><keywords_en><![CDATA[dimerization, biocatalysis, milli- and microflow devices, bioactive molecules, biotransformation, chemical synthesis]]></keywords_en><summary_hr><![CDATA[U današnjem svijetu sve veći broj ljudi suočava se s kroničnim bolestima i stresom, što zahtijeva inovativne terapijske pristupe. Prirodni spojevi predstavljaju značajan izvor bioaktivnih molekula, ali njihova primjena često je ograničena zbog loše bioraspoloživosti i brzog metaboliziranja. Dimerizacija prirodnih spojeva, poput flavonoida i fenola, može poboljšati njihovu biološku aktivnost, povećati stabilnost i omogućiti ciljano djelovanje.Ovaj projekt ima za cilj istražiti kemijsku i enzimatski kataliziranu dimerizaciju i modifikaciju odabranih prirodnih spojeva (apigenin, rezveratrol, ferulinska kiselina i kumarin) kako bi se stvorile nove/poboljšale postojeće bioaktivne molekule. Optimizacijom reakcijskih uvjeta, usporedbom protočnih i šaržnih, mili/mikro i makrosustava, modifikacijom dobivenih spojeva te ocjenom biološke aktivnosti, predloženo istraživanje nastoji unaprijediti sintezu te posljedično proširiti primjenu bioaktivnih molekula.Interdisciplinarni pristup integrirat će spoznaje iz organske kemije, kemijskog inženjerstva, biokatalize i aditivne tehnologije kako bi se odgovorilo na ključne izazove i stvorili preduvjeti za širu primjenu prirodnih dimera u područjima vezanim za zdravlje. Prednosti mikroreaktorskih sustava, poput boljeg prijenosa tvari i topline te kraćih vremena zadržavanja, omogućiti će ekološki prihvatljiviju sintezu dimera u usporedbi s konvencionalnim metodama. Osim toga, primjena imobiliziranih enzima ili cijelih stanica povećati će učinkovitost procesa i omogućuje kontinuiranu proizvodnju uz smanjenje otpada.Rezultati ovog istraživanja mogu doprinijeti razvoju inovativnih bioaktivnih spojeva s primjenom u farmaceutskoj, prehrambenoj i kozmetičkoj industriji te unaprijediti održive metode sinteze integracijom  biokatalize i mikroreaktorske tehnologije.]]></summary_hr><summary_en><![CDATA[In today&#39;s world, more and more people are confronted with chronic diseases and stress, which requires innovative therapeutic approaches. Natural compounds represent a significant source of bioactive molecules, but their application is often limited due to poor bioavailability and rapid metabolism. Dimerization of natural compounds, such as flavonoids and phenols, can improve their biological activity, increase stability and enable targeted action.This project aims to investigate the chemical and enzymatic catalyzed dimerization and modification of selected natural products (apigenin, resveratrol, ferulic acid and coumarin) to create new or improved bioactive molecules. By optimizing the reaction conditions, comparing flow and batch, milli/micro and macro systems, modifying the obtained compounds and evaluating the biological activity, the proposed research aims to improve the synthesis and consequently expand the application of bioactive molecules.An interdisciplinary approach will integrate knowledge from organic chemistry, chemical engineering, biocatalysis and additive technology to address key challenges and set the stage for a broader application of natural dimers in health-related fields. The advantages of microreactor systems, such as better mass and heat transfer and shorter residence times, will enable a more environmentally friendly synthesis of dimers compared to conventional methods. In addition, the use of immobilized enzymes or whole cells will increase the efficiency of the process and enable continuous production while reducing waste.The results of this research can contribute to the development of innovative bioactive compounds for use in the pharmaceutical, food and cosmetics industries and improve sustainable synthesis methods through the integration of biocatalysis and microreactor technology.]]></summary_en></project><project>
<id>17960</id><title_hr><![CDATA[Creating synergies in Widening countries on the topic of low-voltage grid management (SynGRID)]]></title_hr><title_en><![CDATA[]]></title_en><user_id>29523</user_id><user_firstLast_name>Goran Knežević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-2389</code><acronim><![CDATA[]]></acronim><duration>01.01.2026 - 31.12.2031</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera Osijek, Fakultet elektrotehnike, računarstva i informacijskih tehnologija Osijek]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Electrical Engineering, Computer Science and Information Technology Osijek]]></institution_en><team_members_id>872997</team_members_id><team_members_names><![CDATA[ Doktorand: Helena Bošnjak ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>17965</id><title_hr><![CDATA[Redizajn ambalaže proizvoda radi povećanja privlačnosti i prodaje zdrave hrane]]></title_hr><title_en><![CDATA[Reforming packaging shapes to improve the appeal and sales of healthy foods]]></title_en><user_id>25499</user_id><user_firstLast_name>Ružica Brečić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-7777</code><acronim><![CDATA[ShapeShifters]]></acronim><duration>12.01.2026 - 11.01.2029</duration><status>U tijeku</status><financ_value>188.025,00 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, </scie_field_hr><scie_field_en>Economy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Ekonomski fakultet u Zagrebu]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Economics and Business]]></institution_en><team_members_id>870771, 870781, 27310, 868340, 4385, 25540, </team_members_id><team_members_names><![CDATA[Matthew Gorton, Robert Angell, Ines Dužević, Tomislav Baković, Petar Sorić, Miroslav Mandić, ]]></team_members_names><keywords_hr><![CDATA[Pakiranje proizvoda, Zdrava hrana, Ponašanje potrošača, Eksperimentalno istraživanje, Marketinške intervencije]]></keywords_hr><keywords_en><![CDATA[Product Packaging, Healthy Food, Consumer Behavior, Experimental Research, Marketing Interventions]]></keywords_en><summary_hr><![CDATA[Nezdrave prehrambene navike i pretilost predstavljaju velike javnozdravstvene izazove u Hrvatskoj, Europi i globalno. Unatoč sve većoj svjesnosti o rizicima, nezdrava prehrana ostaje raširena. Iako su prethodna istraživanja ispitivala intervencije poput nutritivnog označavanja, cijena i zdravstvenih poruka, uloga dizajna ambalaže u poticanju izbora zdravih, ali manje privlačnih namirnica, ostaje nedovoljno istražena. Ambalaža je snažan marketinški alat, no malo se zna o tome kako njezini strukturni elementi – poput oblika i forme – utječu na percepciju zdravih proizvoda i namjeru kupnje.Ovaj projekt istražuje može li prilagodba dizajna ambalaže povećati privlačnost zdravih proizvoda, osobito među potrošačima koji ih inače izbjegavaju. Kroz kombinaciju kontroliranih eksperimenata i terenskog istraživanja u suradnji s vodećim hrvatskim proizvođačem hrane (Podravka), ispitat će se kako različite demografske skupine reagiraju na dizajn ambalaže te koji čimbenici, poput dobi, spola i prethodne svijesti o zdravlju, utječu na te reakcije.Integrirajući spoznaje iz marketinga, potrošačke psihologije i bihevioralne ekonomije, istraživanje koristi multimetodski pristup, uključujući AI analizu ambalaže i analizu potrošačkog ponašanja u stvarnim uvjetima. Rezultati će donijeti konkretne preporuke za proizvođače, trgovce i kreatore politika, nudeći skalabilnu strategiju za poticanje zdravijih prehrambenih navika. Interaktivne radionice osigurat će primjenu rezultata u praksi. Iskorištavanjem ambalaže kao alata za promicanje zdravijih izbora, ovo istraživanje doprinosi akademskim raspravama i pruža industriji smjernice za učinkovite strategije poticanja zdravije prehrane.]]></summary_hr><summary_en><![CDATA[Unhealthy dietary habits and obesity pose major public health challenges in Croatia, Europe, and globally. Despite growing awareness of the risks, unhealthy food consumption remains widespread. While prior research has examined interventions such as nutrition labeling, pricing strategies, and other nudging techniques, the role of packaging design in influencing consumer choices for healthy yet often stigmatized foods remains underexplored. Packaging is a powerful marketing tool, yet little is known about how its structural elements—such as shape and form—affect perceived healthiness and purchase intent.Drawing upon theories of attractiveness, health perception, and decision-making from consumer psychology and behavioral sciences, this project addresses this gap by investigating whether strategic modifications in packaging design can enhance the appeal of healthy foods, particularly among consumers who might otherwise overlook them. Through a combination of controlled experiments and a field study in collaboration with a major Croatian food manufacturer (Podravka), the research examines how different demographic groups respond to various packaging designs and explore key moderators such as age, gender, and prior health awareness.Integrating insights from marketing, consumer psychology, and behavioral economics, this mixed-methods study will employ AI-driven packaging assessments and real-world consumer behavior analysis. The findings will provide actionable insights for food manufacturers, retailers, and policymakers, offering a scalable and innovative strategy to encourage healthier eating habits. Interactive workshops will ensure impact across target audiences. By leveraging packaging as a behavioral intervention, this research advances academic discussions on consumer decision-making while equipping industry leaders with tools to drive healthier food choices at scale.]]></summary_en></project><project>
<id>17973</id><title_hr><![CDATA[Osiguravanje dostupnosti vode u promjenjivoj klimi]]></title_hr><title_en><![CDATA[]]></title_en><user_id>25784</user_id><user_firstLast_name>Zoran Kovač</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-9359</code><acronim><![CDATA[]]></acronim><duration>01.01.2026 - 31.12.2031</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Rudarstvo, nafta i geološko inženjerstvo, </scie_field_hr><scie_field_en>Mining, petroleum and geological engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Rudarsko-geološko-naftni fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mining, Geology and Petroleum Engineering]]></institution_en><team_members_id>872972</team_members_id><team_members_names><![CDATA[ Doktorand: Lara Antoš ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>17979</id><title_hr><![CDATA[Prostorne modulacije gvanidina]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4851</user_id><user_firstLast_name>Anamarija Briš</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-8935</code><acronim><![CDATA[Space-G]]></acronim><duration>02.02.2026 - 01.02.2031</duration><status>U tijeku</status><financ_value>60,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>873019</team_members_id><team_members_names><![CDATA[ Doktorand: Josipa Šajnović ]]></team_members_names><keywords_hr><![CDATA[Gvanidini, Organska kemija, Bazičnost, Računalna kemija, Molekulsko modeliranje, Senzori, Kataliza]]></keywords_hr><keywords_en><![CDATA[Guanidines, Organic chemistry, Basicity, Computational chemistry, Molecular modelling, Sensors, Catalysis]]></keywords_en><summary_hr><![CDATA[Projekt je usmjeren na proučavanje intrinzičnih svojstava gvanidina, njihove visoke bazičnosti i njihove upotrebe kao katalizatora i anionskih senzora. Istraživački pristup projekta Space-G usko je povezana kombinacija teorijskih i eksperimentalnih studija koje uključuju kvantno-kemijske proračune visoke razine za dizajn, kemijsku sintezu i fizikalno-kemijsku karakterizaciju svojstava novih molekula.Cilj Space-G-a je istražiti temeljna fizikalno-kemijska svojstva (poli)cikličkih gvanidina koji su prostorno modulirani prisutnošću promišljeno postavljenih funkcionalnih skupina.Ciljevi su: a) Dizajn funkcionaliziranih cikličkih gvanidinskih molekularnih sustava; b) Sinteza (poli)cikličkih gvanidinskih molekularnih sustava koji posjeduju funkcionalne skupine primjenom ekološki prihvatljivih sintetskih metoda i njihova spektroskopska i strukturna karakterizacija; c) Detaljan uvid u posljedice ugradnje prostorno bliskih funkcionalnih skupina u strukture gvanidina na (super)bazična svojstva i reakcijske mehanizme primijenjenih organskih reakcija; d) Određivanje anionskog vezanja, katalitičkih i supramolekulskih svojstava funkcionaliziranih gvanidinskih sustava.Dobiveni rezultati unaprijedit će temeljno razumijevanje utjecaja prostorno bliskih supstituenata na fizikalno-kemijske čimbenike koji reguliraju (super)bazičnost gvanidina u cikličkim sustavima. Očekivani rezultati će unaprijediti dizajn, prostornu modulaciju i pripremu novih funkcionaliziranih cikličkih gvanidinskih sustava koji bi se mogli primijeniti u različitim istraživačkim područjima uključujući detekciju aniona, katalizu i supramolekularnu kemiju.Izvedivost predloženog istraživanja opravdana je literaturnim presedanima i dobro dokumentiranim iskustvom istraživačkog tima o istraživačkim temama vezanim uz ovaj projekt.]]></summary_hr><summary_en><![CDATA[Project is focused on study of intrinsic properties of guanidines, their high basicity and their utilization as catalysts and anion sensors. Research approach of the Space-G project is tightly connected combination of theoretical and experimental studies which include high level quantum-chemical calculations for the design, chemical synthesis and physico-chemical characterisation of properties of novel molecules.The goal of Space-G is to investigate fundamental physico-chemical properties of (poly)cyclic guanidines which are spatially modulated by the presence of judiciously positioned functional groups.The objectives are: a) Design of functionalized cyclic guanidine molecular systems; b) Synthesis of (poly)cyclic guanidine molecular systems possessing functional groups by employment of environmentally friendly synthetic methods and their spectroscopic and structural characterization; c) Detailed insight into the consequence of incorporating spatially close functional groups in guanidine structures on (super)basic properties and reaction mechanisms of applied organic reactions; d) Evaluation of anion binding, catalytic and supramolecular properties of functionalized guanidine systems.The obtained results will enhance the fundamental understanding of influence of spatially close substituents on physico-chemical factors governing guanidine (super)basicity in cyclic systems. Expected results will advance design, spatial modulation and preparation of novel functionalized cyclic guanidine systems which could be applied in different research areas including anion sensing, catalysis and supramolecular chemistry.Feasibility of the proposed research is justified by literature precedents and well documented experience of the research team on the research topics related to this project.]]></summary_en></project><project>
<id>17980</id><title_hr><![CDATA[Utjecaj različitih temperaturnih režima na dinamiku domaćina i patogena u slatkovodnim ekosustavima]]></title_hr><title_en><![CDATA[]]></title_en><user_id>19913</user_id><user_firstLast_name>Sandra Hudina</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-3121</code><acronim><![CDATA[DRoP]]></acronim><duration>01.02.2026 - 31.01.2032</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>873051</team_members_id><team_members_names><![CDATA[ Doktorand: Karolina Pipinić ]]></team_members_names><keywords_hr><![CDATA[Aphanomyces astaci, riječni rak, ne-konstantni temperaturni režimi, toplinski val, sekvenciranje RNA, modeliranje]]></keywords_hr><keywords_en><![CDATA[Aphanomyces astaci, noble crayfish, non-constant temperature regime, heat wave, RNA-sequencing, modelling]]></keywords_en><summary_hr><![CDATA[Dinamičan odnos domaćina i patogena ovisi o interakciji između domaćina, patogena i okoliša. Među okolišnim čimbenicima, temperatura snažno utječe na domaćina, patogena i njihovu interakciju. U kontekstu globalnog zatopljenja, temperaturni režimi u slatkovodnim okolištima se mijenjaju, uključujući postupno povećanje prosječne temperature vode i povećanje frekvencije, trajanja i magnitude ekstremnih temperaturnih događaja, kao što su toplinski valovi. Biološki učinci realističnih temperaturnih režima, poput dnevnih temperaturnih fluktuacija i toplinskih valova, do sada su u velikoj mjeri neistraženi. Stoga je naš cilj istražiti učinke različitih temperaturnih režima na dinamiku domaćina i patogena.Kao model koristit ćemo račju kugu, bolest deseteronožnih rakova uzrokovanu patogenom Aphanomyces astaci. Istražit ćemo učinke različitih temperaturnih režima na (1) patogena, (2) domaćina i (3) interakcije domaćina i patogena kombiniranjem različitih pristupa: (i) istraživanjem mehanizama ovisnosti patogena o temperaturi praćenjem preživljenja/rasta i funkcionalne ekspresije gena; (ii) istraživanjem učinka temperature na samog domaćina i interakciju domaćina i patogena putem laboratorijskih infekcijskih pokusa na svim razinama, od ekspresije bolesti do imunosnog odgovora domaćina. Rezultate ćemo sintetizirati primjenom dvije komplementarne vrste modela za predviđanje dinamike bolesti pod različitim temperaturnim režimima: (i) DEB-modeli (engl. Dynamic Energy Budget) za predviđanje kombiniranih učinaka temperature i patogena na metabolizam i rast domaćina, i (ii) modeli distribucije vrsta (engl. Spatial Distribution models, SDMs) za predviđanje promjena u potencijalnoj distribuciji ciljanih vrsta pod različitim temperaturnim scenarijima. Izvodljivost projekta temelji se na bogatoj bazi postojećih preliminarnih podataka i ekspertizama komplementarnog i multidisciplinarnog tima znanstvenika u Hrvatskoj i Švicarskoj.]]></summary_hr><summary_en><![CDATA[Host-pathogen dynamics depends on the interaction between the host, the pathogen and the environment. Amongst environmental factors, temperature strongly impacts the host, the pathogen, and their interaction. In the context of global warming, temperature regimes in freshwater environments are changing, including both gradual increase in the mean water temperature and increase in frequency, duration and magnitude of extreme temperature events, such as heat waves. Biological effects of realistic temperature regimes, like diurnal temperature fluctuations and heat waves, are largely unexplored to date. Thus, we aim to explore the effects of different temperature regimes on host-pathogen dynamics.As a model we will use crayfish plague, a disease of noble crayfish caused by Aphanomyces astaci. To gain an in-depth understanding, we will investigate effects of different temperature regimes on (1) the pathogen, (2) the host and (3) host-pathogen interactions by simultaneously applying and combining different approaches: (i) exploring the mechanisms of pathogen temperature-dependence by investigating the viability/growth and functional gene expression; (ii) exploring the effect of temperature on host alone and host-pathogen interaction by laboratory infection trials at all levels, from disease expression to host immune response. We will synthesize the results by applying two complementary modelling approaches to predict disease dynamics under different temperature regimes: (i) Dynamic Energy Budget (DEB) models to predict the combined effects of temperature and pathogen stress on the host metabolism and growth, and (ii) Species Distribution Models (SDMs) to predict changes in the potential distribution of target species under different temperature scenarios. The feasibility of the project is possible by the solid base of existing preliminary data and the expertise of the established complementary and multidisciplinary team of scientists in Croatia and Switzerland.]]></summary_en></project><project>
<id>17984</id><title_hr><![CDATA[Integrirani mikrosustav za enzimatsku proizvodnju biovodika]]></title_hr><title_en><![CDATA[]]></title_en><user_id>428</user_id><user_firstLast_name>Anita Šalić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-9757</code><acronim><![CDATA[MicroBioH2]]></acronim><duration>12.11.2025 - 11.11.2031</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Kemijsko inženjerstvo, </scie_field_hr><scie_field_en>Chemical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet kemijskog inženjerstva i tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Chemical Engineering and Technology]]></institution_en><team_members_id>872946</team_members_id><team_members_names><![CDATA[ Doktorand: Nera Bebek ]]></team_members_names><keywords_hr><![CDATA[hidrogenaza tolerantna na kisik, eskpresija proteina, proizvodnja biovodika, mikroreaktor, integrirani sustav, optimizacija i modeliranje procesa]]></keywords_hr><keywords_en><![CDATA[oxygen tolerant hydrogenase, protein expression, biohydrogen production, microreactor, integrated system, process optimization and modeling]]></keywords_en><summary_hr><![CDATA[Minijaturizacija procesne opreme je jedan od pristupa koji se danas sve više koristi kako bi se intenzivirali procesi. Mali, kompaktni i prijenosni uređaji, koji se koriste na mjestu nastanka sirovine ili na mjestu primjene produkta, pronalaze brojne primjene u kemijskoj, farmaceutskoj i prehrambenoj industriji, proizvodnji biogoriva, medicini, senzorici, praćenju stanja okoliša i sl. Široka primjena mikrostruktiriranih uređaja u proizvodnji energije zavisi o mogućnosti izvedbe uređaja koji će biti održivi, trajni, ekonomski opravdani i prihvatljivi po okoliš. U današnje vrijeme su biogoriva (bioetanol, biodizel, bioplin i biovodik) ekonomski i po okoliš prihvatljiva alternativa fosilnim gorivima. U odnosu na druga biogoriva, vodik ima visok energetski potencijal, njegovim korištenjem ne nastaju emisije štetnih plinova, a specifična energija koju se dobiva iz vodika je 2,75 puta veća od energije koja nastaje iz goriva na bazi ugljikovodika.Vodik se proizvod različitim procesima, a u odnosu na kemijske procese, biološke procese proizvodnje vodika odlikuje manja specifična potrošnja energije, blagi reakcijski uvjeti, a kao supstrati se koriste prirodne komponente.U okviru projekta provest će proizvodnja biovodika u reakcijskom sustavu temeljenom na oksidaciji glukoze enzimom glukoza dehidrogenaza, koji za svoje djelovanje zahtjeva prisutnost koenzima NADP+. Regeneracijom koenzima enzimom, nastaju dva mola vodika po molu glukoze. U okviru razvoja potpuno integriranog proces proizvodnje biovodika u mikroreaktoru, proizvest će se enzim hidrogenaza iz Ralstonia eutropha H16 i genetski modificirane Escherichia coli. Proizvodnja biovodika provest će se u šaržnom i ponovljivom šaržnom reaktoru te u mikroreaktoru. Sastav medija i procesni uvjeti bit će optimirani, a uz vodene, kao reakcijski medij koristit će se i prirodna eutektička otapala s ciljem stabilizacije enzima i koenzima. Na kraju će se u svrhu optimizacije i uvećanja procesa razviti kinetički i matematički model.]]></summary_hr><summary_en><![CDATA[One of the approaches widely used today to intensify processes is miniaturization of process equipment. Small, compact and portable devices used at the source of the raw material or at the point of application of the product have numerous applications in the chemical, pharmaceutical and food industries, biofuel production, medicine, sensor technology, environmental monitoring, etc. The wide application of microstructured devices in power generation depends on the ability to produce devices that are sustainable, durable, economically justified, and environmentally sound. Nowadays, biofuels are economically and environmentally acceptable alternatives to fossil fuels. Hydrogen is the most promising alternative energy solution because it has a high energy potential, no harmful gasses are released during its use, and the specific energy obtained is 2.75 times greater than the energy obtained from hydrocarbon-based fuels.Compared to chemical processes of hydrogen production, biological processes are characterized by lower specific energy consumption, the process takes place under mild reaction conditions, and natural components are used as substrates.In the proposed research, the production of biohydrogen will be carried out in a reaction system based on the oxidation of glucose by the glucose dehydrogenase, which requires the presence of the coenzyme NADP+ for its catalytic action. Two moles of biohydrogen per mole of glucose are generated during coenzyme regeneration by hydrogenase. Hydrogenase will be produced using Ralstonia eutropha H16 and by expression of recombinant protein in E. coli. Biohydrogen production will be carried out in a batch and repetative batch reactor and in a microreactor. The medium composition and process conditions will be optimized, and natural deep eutectic solvents will be used in addition to aqueous media to stabilize enzymes and coenzymes. Finally, a kinetic and mathematical model will be developed to optimize and scale-up the process.]]></summary_en></project><project>
<id>17987</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Karmen Kapustić]]></title_hr><title_en><![CDATA[]]></title_en><user_id>870133</user_id><user_firstLast_name>Karmen Kapustić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-7260</code><acronim><![CDATA[]]></acronim><duration>01.09.2025 - 30.11.2025</duration><status>U tijeku</status><financ_value>7.735,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut za fiziku]]></institution_hr><institution_en><![CDATA[Institute of Physics in Zagreb]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>17988</id><title_hr><![CDATA[Uloga bradikinina i glukoznih transportera u kognitivnim i neurovaskularnim promjenama uzrokovanima dijabetesom]]></title_hr><title_en><![CDATA[The role of bradykinin and glucose transporters in diabetes induced cognitive and neurovascular dysfunction]]></title_en><user_id>6226</user_id><user_firstLast_name>Marina Radmilović (Dobrivojević)</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-7524</code><acronim><![CDATA[CANDy]]></acronim><duration>05.12.2025 - 04.12.2028</duration><status>U tijeku</status><financ_value>199.996,50 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>25188, 25294, 22754, 12709, 870145, 22595, 865161, </team_members_id><team_members_names><![CDATA[Helena Justić, Anja Barić, Milorad Zjalić, Siniša Škokić, Ivana Mišerić, Sandra Grgić, Marta Pongrac, ]]></team_members_names><keywords_hr><![CDATA[dijabetes, mozak, kognitivno propadanje, glukozni transporteri, bradikinin]]></keywords_hr><keywords_en><![CDATA[diabetes, brain, cognitive decline, glucose transporters, bradykinin]]></keywords_en><summary_hr><![CDATA[Dijabetes je kronični metabolički poremećaj s brzorastućom globalnom prevalencijom i značajnim utjecajem na zdravlje mozga. Osim poznatih učinaka na periferni metabolizam glukoze, dijabetes mijenja moždani transport glukoze i energetsku homeostazu, pridonoseći neurovaskularnoj disfunkciji i kognitivnom propadanju. Glukozni transporteri (GLUT) reguliraju unos glukoze u moždano tkivo, a sve više dokaza upućuje na to da poremećaj funkcije GLUT-ova u dijabetesu ubrzava neurodegeneraciju. Međutim, mehanizmi koji upravljaju regulacijom GLUT-ova u mozgu još uvijek nisu u potpunosti razjašnjeni. Bradikininski receptor tipa 2 (B2R) poznat je po svojoj ulozi u regulaciji metabolizma glukoze u perifernim tkivima, no njegova uloga u homeostazi glukoze u mozgu nije dosad istraživana. Naši preliminarni rezultati sugeriraju da nedostatak B2R-a mijenja ekspresiju GLUT-a u mozgu, ističući moguću povezanost bradikinina i regulacije glukoze u mozgu. Ovim projektom želimo istražiti ulogu B2R-a u transportu glukoze u mozgu u fiziološkim i dijabetičkim uvjetima, analizirajući njegov utjecaj na unos glukoze u mozgu kod zdravih i dijabetičkih životinja, razotkrivajući mehanizme njegove regulacije u primarnim kulturama moždanih stanica te procjenjujući njegov učinak na neurovaskularni integritet i kognitivne funkcije. U svrhu navedenoga, koristit ćemo kombinaciju molekularnih, slikovnih i bihevioralnih metoda, uključujući in vivo optičko snimanje, MRI, testove unosa glukoze, analize ekspresije gena i proteina te kognitivno testiranje. Očekivani rezultati pružit će ključne uvide u međudjelovanje bradikinina i moždanog metabolizma, s važnim implikacijama za razjašnjenje mehanizama neurodegeneracije i kognitivnog propadanja povezanih s dijabetesom. Ovo istraživanje može doprinijeti identifikaciji novih terapijskih ciljeva usmjerenih na očuvanje moždane funkcije kod dijabetičkih pacijenata, čime bi se unaprijedio klinički pristup metaboličkim poremećajima mozga.]]></summary_hr><summary_en><![CDATA[Diabetes mellitus is a chronic metabolic disorder with rapidly increasing global prevalence and significant impact on brain health. Beyond its well-known effects on peripheral glucose metabolism, diabetes alters cerebral glucose transport and energy homeostasis, contributing to neurovascular dysfunction and cognitive decline. Glucose transporters (GLUT) regulate cerebral glucose uptake, and emerging evidence suggests that dysregulation of GLUT function in diabetes accelerates neurodegeneration. However, the precise mechanisms governing GLUT regulation in the brain remain poorly understood. The bradykinin type 2 receptor (B2R) is known to influence glucose metabolism in peripheral tissues, yet its role in brain glucose homeostasis remains unexplored. Our preliminary findings suggest that B2R deficiency alters GLUT expression in the brain, highlighting a potential link between bradykinin signaling and cerebral glucose regulation. This project aims to investigate the role of B2R in brain glucose transport under both physiological and diabetic conditions by examining its influence on cerebral glucose uptake in non-diabetic and diabetic animals, uncovering its regulatory mechanisms in brain cell cultures, and assessing its impact on neurovascular integrity and cognition. A combination of molecular, imaging, and behavioral approaches, including in vivo optical imaging, MRI, glucose uptake assays, gene and protein expression analyses, and cognitive testing, will be used to uncover how B2R influences glucose homeostasis in the brain. The anticipated findings will provide crucial insights into the interplay between bradykinin signaling and cerebral metabolism, with implications for diabetes-related neurodegeneration and cognitive dysfunction. This research has the potential to identify novel therapeutic targets aimed at preserving brain function in diabetic populations, ultimately contributing to improved clinical management of metabolic brain disorders.]]></summary_en></project><project>
<id>17989</id><title_hr><![CDATA[Horticultural innovations in soil-friendly practices to ensure a sustainable future (Hort2thefuture)]]></title_hr><title_en><![CDATA[]]></title_en><user_id>22828</user_id><user_firstLast_name>Nikola Major</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-3738</code><acronim><![CDATA[]]></acronim><duration>01.11.2025 - 31.10.2030</duration><status>U tijeku</status><financ_value>60,00 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Prehrambena tehnologija, </scie_field_hr><scie_field_en>Food technology, </scie_field_en><institution_hr><![CDATA[Institut za poljoprivredu i turizam]]></institution_hr><institution_en><![CDATA[Institute of Agriculture and Tourism in Poreč]]></institution_en><team_members_id>872872</team_members_id><team_members_names><![CDATA[ Doktorand: Ana Milardović ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>17991</id><title_hr><![CDATA[Analiza singulariteta i fiksnih točaka kompleksnih dinamičkih sustava]]></title_hr><title_en><![CDATA[Analysis of singularities and fixed points of complex dynamical systems]]></title_en><user_id>2709</user_id><user_firstLast_name>Maja Resman</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-1147</code><acronim><![CDATA[ANAKODI]]></acronim><duration>31.01.2026 - 30.01.2029</duration><status>U tijeku</status><financ_value>159.547,45 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>26243, 29727, 870351, 870465, 3200, 2932, 1391, 869778, </team_members_id><team_members_names><![CDATA[Dino Peran, Vlatko Crnković, Daniel Cantergiani Panazzolo, Loic Teyssier, Pavao Mardešić, Goran Radunović, Vesna Županović, Luka Kraljević, ]]></team_members_names><keywords_hr><![CDATA[sedlo-čvor razlaganje, parabolička dinamika, Borel transformacija, fraktalna zeta funkcija, anal. moduli, policiklus, Dulacovo preslikavanje,rigidnost]]></keywords_hr><keywords_en><![CDATA[saddle-node unfolding, local parabolic dynamics, Borel transform, fractal zeta function, analytic moduli, polycycles, Dulac maps, rigidity]]></keywords_en><summary_hr><![CDATA[Projekt je iz područja dinamičkih sustava. Šire, bavi se lokalnom analizom analitičkih dinamičkih sustava (kontinuiranih-zadanih vektorskim poljima ili diskretnih-zadanih iteracijama difeomorfizma), lokalno oko singularnih ili fiksnih točaka. Singulariteti su najjednostavniji primjeri invarijantnih skupova za dinamiku. Dalje od invarijantnih skupova, sustavi se ponašaju slično ako malo promijenimo početnu točku i tok se može prevesti u paralelni analitičkom zamjenom varijabli. Singulariteti općenito pokazuju zanimljivu dinamiku iteracija u svojim okolinama.Diskretni sustav, koji je ponekad lakše analizirati, može se &#39;umetnuti&#39; u kontinuirani kao njegov 1-tok; obično se koristi 1-tok ili neko preslikavanje povrata (holonomija) u slučaju folijacija s monodromijama. Stoga je često dovoljno promatrati diskretne sustave kao  &#39;&#39;reprezentacije&#39;&#39; kontinuiranih. U ovom projektu bavimo se dinamičkim sustavima i folijacijama u jednoj ili više kompleksnih varijabli.Zanimaju nas klasifikacijski problemi za takve sustave, odnosno pronalaženje invarijanti koje nam govore mogu li se dva sustava transformirati jedan u drugi analitičkom zamjenom varijabli. Točnije, zanimljivi problemi u holomorfnoj diskretnoj dinamici su iracionalne rotacije u linearnom dijelu i klasifikacije paraboličnih klica (=s linearnim dijelom jednakim identiteti) u dimenziji 2 ili više, te Dulacova prelikavanja tipa potencija-logaritam koja se javljaju kao preslikavanja povrata oko policiklusa. Također, vraćamo se na pitanje iščitavanja analitičkih invarijanti za generička 1-parametarska razlaganja vektorskih polja u dimenziji 1 (pri čemu se parabolička fiksna točka multipliciteta 2 razlaže u dvije jednostruke hiperboličke fiksne točke). Pitanje koje postavljamo  je sljedeće: možemo li očitati analitičku klasu bifurkacije promatrajući samo jednu realizaciju (orbitu) razlaganja? U tu svrhu, orbite analiziramo fraktalno, odgovarajućim integralnim transformacijama  njihovih epsilon-okolina.]]></summary_hr><summary_en><![CDATA[The project is in the area of dynamical systems and deals, broadly, with local analysis (at singular resp. fixed points) of analytic dynamical systems (continuous-represented by vector fields or discrete-represented by iterates of a diffeomorphism). The singularities are the simplest examples of invariant sets for the dynamics. Away from invariant sets, the system behaves similarly if we slightly change the initial point. The flow can be rectified to a simple parallel flow by an analytic change of variables. Singularities, in general, display interesting dynamical behavior of trajectories in their vicinity. The discrete system, which is sometimes easier to analyse, can be &#39;embedded&#39; in the continuous one as its time map; one uses time-1 map or some return map/holonomy in the case of monodromic foliations. In general, it suffices to consider the discrete systems as &#39;representations&#39; of the continuous ones. In this project we deal with systems and foliations in one or more complex variables. We are interested in classification problems for such systems, i.e. finding the invariants that tell us when the two systems can be transformed one to another by an analytic change of variables. More precisely, the interesting problems in holomorphic discrete dynamics are irrational rotations in the linear part and classifications of parabolic germs (=with linear part equal to identity) in dimension 2, as well as  Dulac germs power-logarithmic germs that appear as first return maps around polycyles. Also, we return to the question of reading analytic invariants for the generic one-parameter unfoldings of vector fields (whereas the parabolic point of multiplicity 2  unfolds into two simple points). Here, the main question that we pose is the following: can we read the analytic class of the unfolding considering just one local realization (orbit) of the unfolding? To that end, we analyse the orbits fractally, i.e. by an appropriate integral transform of their epsilon-neighborhoods. ]]></summary_en></project><project>
<id>17993</id><title_hr><![CDATA[Testiranje LCDM modela koristeći efektivnu teoriju polja formacije kozmoloških struktura]]></title_hr><title_en><![CDATA[Testing the LCDM cosmology with the effective field theory of cosmological structure formation]]></title_en><user_id>24960</user_id><user_firstLast_name>Zvonimir Vlah</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-1338</code><acronim><![CDATA[pt4LCDM]]></acronim><duration>05.12.2025 - 04.12.2028</duration><status>U tijeku</status><financ_value>184.400,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>867504, 868085, 868242, </team_members_id><team_members_names><![CDATA[Giovanni Cabass, Cornelius Stefan Rampf, Nora Elisa Chisari, ]]></team_members_names><keywords_hr><![CDATA[kozmologija, perturbacijska teorija, LCDM model, spektar snage, bispektar]]></keywords_hr><keywords_en><![CDATA[cosmology, perturbation theory, LCDM model, power spectrum, bispectrum]]></keywords_en><summary_hr><![CDATA[S pojavom nadolazećih opažačkih istraživanja kao što su DESI (koje je već u fazi prikupljanja i analize podataka, s objavljenim rezultatima iz prve godine koji će uskoro biti i javno dostupni) i Euclid (uspješno lansiran i u fazi prikupljanja podataka), kozmologija stoji na rubu novih otkrića potaknutih bogatstvom novih mapa distribucija galaksija na našem nebu. Kako bismo iskoristili vrijednost ovih podataka, potrebna su nam ekvivalentno precizna teorijska predviđanja. Trenutačno, kanonički LCDM kozmološki model je robustan, ali da bismo definitivno otkrili bilo kakva odstupanja ili signale nove fizike, potrebna su nam izuzetno točna teorijska predviđanja unutar ovog modela. Imajući ovaj cilj na umu, predlažemo značajan razvoj trenutne analize zasnovane na perturbacijskoj teoriji, prvo proširenjem spektra snage s jednom petljom na dvije petlje. To će poboljšati i točnost i raspon skala naše upotrebe postojećih podataka. Nadalje, unutar istog okvira modeliranja, namjeravamo uključiti bi-spektralnu analizu s jednom petljom, koja će se uspoređivati s postojećim predviđanjima. Ovaj je projekt posebno aktualan u svjetlu nedavnog računalnog napretka koji su postigli glavni istraživač (PI) i suradnici, a koji je kulminirao razvojem novog računalnog okvira nazvanog COBRA (Optimalna faktorizacija kozmoloških opservabli), nedavno prihvaćenog za objavu u PRL. Ova inovacija omogućuje izrazito, i bez presedana, učinkovit i brz izračun integrala petlje višeg reda karakterističnih za kozmološku perturbacijsku teoriju, značajno povećavajući izvedivost primjene predviđanja teoretskih modela, izvedenih iz prvih principa, na analizu podataka i time značajno povećavajući korisnost ovih opažačkih istraživanja.]]></summary_hr><summary_en><![CDATA[With the advent of upcoming surveys such as DESI (already in the data collection and analysis phase, with Year 1 results published and soon to be public) and Euclid (successfully launched and collecting data), cosmology stands on the brink of new discoveries facilitated by the wealth of pristine galaxy sky distribution maps. To capitalize on the value of this data, we need equally excellent and precise predictions from our theoretical framework. Presently, the canonical LCDM cosmological model remains robust, yet to definitively unearth any deviations or signatures of new physics, we need to have an exquisitely accurate theoretical prediction of this model. With this objective in mind, we propose substantial development of the current perturbation theory-based analysis, first extending the one-loop power spectrum to two-loops. This will enhance both the accuracy and scale coverage of our utilization of existing data. Furthermore, within the same modelling framework, we intend to incorporate a one-loop bispectrum analysis, which will be compared and benchmarked against the established predictions in the field. This project is particularly timely in light of the recent computational breakthrough achieved by the Principal Investigator (PI) and collaborators, culminating in the development of a novel computational framework dubbed COBRA (Optimal Factorization of Cosmological Observables), accepted in the PRL. This innovation enables unprecedentedly efficient and rapid evaluation of higher-order loop integrals characteristic to cosmological perturbation theory, significantly enhancing the feasibility of applying comprehensive first principle theoretical model predictions to data analysis and thereby maximizing the utility of these surveys.]]></summary_en></project><project>
<id>17994</id><title_hr><![CDATA[Uloga izvanstaničnih vezikula u interakcijama nosilac-patogen: veterinarska perspektiva]]></title_hr><title_en><![CDATA[The role of extracellular vesicles in host-pathogen interactions: a veterinary perspective ]]></title_en><user_id>6734</user_id><user_firstLast_name>Josipa Kuleš</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2025-02</proposal_call><code>UIP-2025-02-7999</code><acronim><![CDATA[HoP-VET]]></acronim><duration>19.02.2026 - 18.02.2031</duration><status>U tijeku</status><financ_value>299.977,50 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Veterinarska medicina, Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Veterinary medicine, Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Veterinarski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Veterinary Medicine]]></institution_en><team_members_id>19799, 6240, 870686, 870127, 870788, 870670, </team_members_id><team_members_names><![CDATA[Dina Rešetar Maslov, Jelena Gotić, Nika Konstantinović, Dominik Prišćan, MAŠA EFENDIĆ, Katarina Marjanović, ]]></team_members_names><keywords_hr><![CDATA[proteomika, metabolomika, izvanstanične vezikule, parazitske bolesti, nosilac-patogen interakcije]]></keywords_hr><keywords_en><![CDATA[proteomics, metabolomics, extracellular vesicles, parasitic diseases, host-pathogen interactions]]></keywords_en><summary_hr><![CDATA[Parazitske bolesti predstavljaju značajnu prijetnju zdravlju ljudi i životinja, dovodeći do ozbiljnih javnozdravstvenih problema te uzrokujući globalne medicinske i ekonomske posljedice. Razumijevanje interakcija između nosioca i patogena ključno je za razjašnjavanje mehanizama koji pokreću razvoj bolesti, kao i čimbenika koji doprinose varijabilnim ishodima bolesti među različitim vrstama nosioca. Izvanstanične vezikule (EV) prepoznate su kao visoko očuvan mehanizam međustanične komunikacije koji omogućuje prijenos bioaktivnih molekula između stanica. EV-e sadržavaju širok spektar specifičnih biomolekula unutar lipidne dvoslojne membrane. Naša hipoteza je da EV-e u serumu nosioca odražavaju patofiziološke procese koji se odvijaju na sučelju nosioca i patogena kod različitih parazitskih bolesti od veterinarskog značaja u Hrvatskoj: babezioze pasa, piroplazmoze konja i fascioloidoze jelena. Očekujemo da će se sadržaj EV-a razlikovati između zdravih nosilaca i onih s potvrđenim parazitskim invazijama, kao i među različitim vrstama patogena (unutarstanični i izvanstanični) te različitim fazama invazije. Kako bismo to istražili, izolirat ćemo i karakterizirati EV-e iz seruma invadiranih životinja koristeći kromatografiju isključenjem po veličini u kombinaciji s ultrafiltracijom, transmisijsku elektronsku mikroskopiju, analizu praćenja nanočestica i Western blot. Sveobuhvatan i inovativan omika pristup omogućit će karakterizaciju širokog spektra biomolekula, proteina i metabolita, unutar vezikula. Razumijevanje funkcionalne uloge sadržaja EV-a pružit će ključne uvide u mehanizme bolesti, potencijalno doprinoseći razvoju novih dijagnostičkih i terapijskih strategija u veterinarskoj medicini. Osim toga, ovo istraživanje ima za cilj proširiti primjenu naprednih metodologija za identifikaciju proteina i metabolita povezanih s EV-a, istovremeno jačajući istraživački kapacitet novoformirane istraživačke grupe te unaprjeđujući znanja u molekularnoj veterinarskoj medicini. ]]></summary_hr><summary_en><![CDATA[Parasitic diseases pose a significant threat to both human and animal health, leading to substantial public health concerns and causing widespread medical and economic consequences. Understanding host-pathogen interactions is crucial for elucidating the mechanisms driving disease development, as well as the factors contributing to variable disease outcomes among different host species. Extracellular vesicles (EVs) have emerged as a highly conserved mechanism of intercellular communication, facilitating the transfer of bioactive molecules between cells. EVs encapsulate a diverse array of cell-specific biomolecules within a lipid bilayer membrane. We hypothesize that EVs in host serum reflect the pathophysiological processes occurring at the host-pathogen interface in various parasitic diseases of veterinary significance in Croatia: canine babesiosis, equine piroplasmosis, and deer fascioloidosis. We expect EVs content to differ between healthy hosts and those with confirmed parasitic infections, as well as among different pathogen types (intracellular vs. extracellular) and infection stages. To test this, we will isolate and characterize EVs from the serum of infected animals using size-exclusion chromatography combined with ultrafiltration, transmission electron microscopy, nanoparticle tracking analysis, and Western blotting. A comprehensive and innovative omics approach will be employed to characterize a broad spectrum of molecular species, proteins and metabolites, within EVs. Deciphering the functional role of EV cargo will provide critical insights into disease mechanisms, potentially informing novel diagnostic and therapeutic strategies in veterinary medicine. Moreover, this research aims to expand the application of advanced methodologies for identifying EV-associated proteins and metabolites in host-pathogen interactions while enhancing the research capacity of the newly formed research group and advancing expertise in molecular veterinary medicine.]]></summary_en></project><project>
<id>17997</id><title_hr><![CDATA[Protein-protein interakcije enzima reciklirajućeg puta sinteze purina u Helicobacter pylori]]></title_hr><title_en><![CDATA[Protein-protein interactions of Helicobacter pylori purine salvage pathway enzymes]]></title_en><user_id>690</user_id><user_firstLast_name>Ivana Leščić Ašler</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-8123</code><acronim><![CDATA[PPI-HP]]></acronim><duration>20.12.2025 - 19.12.2028</duration><status>U tijeku</status><financ_value>199.927,50 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Interdisciplinarne prirodne znanosti, Fizika, Kemija, Biologija, </scie_field_hr><scie_field_en>Interdisciplinary natural sciences, Physics, Chemistry, Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>1232, 424, 2999, 870656, 4270, 870459, 870840, </team_members_id><team_members_names><![CDATA[Ivo Crnolatac, Zoran Štefanić, Agnieszka Bzowska, Marta Wojtys, Branimir Bertoša, Victor U. Weiss, Martina Marchetti-Deschmann, ]]></team_members_names><keywords_hr><![CDATA[protein-protein interakcije, sinteza purina, Helicobacter pylori, enzimi, alosterija, karakterizacija proteina, BioID]]></keywords_hr><keywords_en><![CDATA[protein-protein interactions, purine synthesis, Helicobacter pylori, enzymes, allostery, protein characterization, BioID]]></keywords_en><summary_hr><![CDATA[Enzimi koji sudjeluju u sintezi purina predstavljaju obećavajuće mete za sintezu novih lijekova, posebno u bakteriji Helicobacter pylori, koja se oslanja isključivo na reciklirajući put sinteze purina (RPSP), a koji je slabo istražen. U predloženom projektu istražiti ćemo detaljno enzime RPSP, posebno njihove potencijalne stabilne ili prolazne protein-protein interakcije (PPI) u stanici. U prvoj aveniji projekta razviti ćemo protokol za istraživanje PPI u stanicama H. pylori temeljen na metodologiji BioID, koja je prikladna za detekciju čak i slabih ili prolaznih interakcija. Zatim će enzimi RPSP biti pročišćeni i karakterizirani (uporabom niza dostupnih biofizičkih metoda), a interakcije među njima biti će proučene in vitro i in silico. Ključne aminokiseline, identificirane računalnim metodama (dokiranje, simulacije MD) biti će mutirane, mutirani enzimi karakterizirani, te potvrđena njihova nemogućnost stvaranja interakcija (metodama AUC, ITC, nES GEMMA i drugima). Cilj nam je otkriti ostvaruju li ovi enzimi interakcije poput enzima iz de novo sinteze purina (organiziranih u tzv. purinosom), te predstavljaju li te interakcije ili sami enzimi potencijalne farmaceutske mete. U drugoj aveniji projekta ćemo se fokusirati na PPI između podjedinica oligomernih enzima RPSP, kako bismo otkrili aminokiseline presudne za komunikaciju među monomerima (tzv. &#39;&#39;hub residues&#39;&#39;). Poznato je da je oligomerna organizacija enzima čvrsto povezana s njihovom alosteričkom regulacijom, no ne zna se mnogo o točnim rutama i mehanizmima alosterije. Stoga ćemo nastaviti naš rad na relacijskoj bazi proteinskih 3D-struktura i simulacija MD, na razvoju alata za izvlačenje informacija iz te baze i u završnici na potvrdi predviđenih &#39;&#39;hub residues&#39;&#39; enzima RPSP in vitro. Ovaj inovativan pristup svakako će doprinijeti razumijevanju fenomena alosterije.]]></summary_hr><summary_en><![CDATA[Enzymes participating in the synthesis of purines are promising targets for new pharmaceuticals, especially in Helicobacter pylori which relies solely on purine salvage pathway (PSP), which is poorly investigated. In the proposed project, we will examine enzymes of PSP in greater detail, particularly their potential stable or transient protein-protein interactions (PPIs) in the cell. In the first avenue of the project we will develop protocol for investigation of PPIs in H. pylori cells based on BioID methodology which is suitable for detecting even weak and transient interactions. Afterwards, enzymes of H. pylori PSP will be purified and characterized (using an array of available biophysical methods), and interactions between them investigated in vitro and in silico. Key residues identified by computational methods (docking, MD simulations) will be mutated, mutant enzymes characterized and their inability to form interactions verified (by AUC, ITC, nES GEMMA and other methods). We aim to discover whether investigated enzymes form interactions similar to those of de novo purine synthesis enzymes (organized in so-called purinosome), and whether these interactions or enzymes themselves can present potential pharmaceuticals targets. In the second avenue of the project, we will focus on PPIs between subunits of oligomeric enzymes in H. pylori PSP, in order to discover which residues are crucial for communication between monomers (so-called &#39;&#39;hub residues&#39;&#39;). It is known that oligomeric organization of enzymes is closely related to their allosteric regulation, however not much is known about exact routes and mechanism of the allostery. Therefore, we will continue our work on the relational database of protein 3D-structures and MD simulations, on development of tools for mining this database and finally on in vitro confirmation of predicted &#39;&#39;hub residues&#39;&#39; in enzymes of PSP. This innovative approach will surely contribute to the understanding of allostery phenomenon.]]></summary_en></project><project>
<id>17998</id><title_hr><![CDATA[ Integrirani pristup valorizaciji nusproizvoda kave razvojem funkcionalnih dodataka prehrambenih proizvoda]]></title_hr><title_en><![CDATA[Integrated approach to the valorization of coffee by-products by developing functional food ingredients]]></title_en><user_id>4544</user_id><user_firstLast_name>Draženka Komes</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-6834</code><acronim><![CDATA[ReUSECoffee4Food]]></acronim><duration>05.12.2025 - 04.12.2028</duration><status>U tijeku</status><financ_value>199.900,00 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Prehrambena tehnologija, </scie_field_hr><scie_field_en>Food technology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Food Technology and Biotechnology]]></institution_en><team_members_id>1011, 4332, 3709, 13470, 4098, 4102, 4100, 4438, 26476, 23620, 29235, 870204, </team_members_id><team_members_names><![CDATA[Ksenija Durgo, Božidar Šantek, Vlatka Petravić Tominac, Marko Obranović, Antonija Trontel, Mladen Pavlečić, Mario Novak, Aleksandra Vojvodić Cebin, Danijela Šeremet, Nenad Marđetko, Rea Bertoša, Marija Ivić, ]]></team_members_names><keywords_hr><![CDATA[talog kave, srebrna pokožica, galaktomanani, inkapsulacija, oleogelovi, konditorski proizvodi]]></keywords_hr><keywords_en><![CDATA[spent coffee grounds, silver skin, galactomannans, encapsulation, oleogels, confectionery products]]></keywords_en><summary_hr><![CDATA[Istraživanja unutar ovog projekta bit će usmjerena na razvoj inovativnih, integriranih protokola valorizacije taloga i srebrne pokožice kave u cilju izdvajanja visokovrijednih sastojaka, njihove fizikalno-kemijske i biološke karakterizacije te odgovarajuće konverzije u funkcionalne sastojke prehrambenih proizvoda. Za izdvajanje proteina, lipidnih i hidrofilnih bioaktivnih sastojaka (BAS) primijenit će se inovativne tehnike ekstrakcije (mikrovalovi, NADES, superkritični CO2), dok će se za izdvajanje galaktomanana primijeniti alkalna hidroliza nusproizvoda, uz prethodnu predobradu (delignifikacija, enzimski ili fizikalni postupci). Razvit će se nove metodologije za primjenu hidrolizata nusproizvoda kave u proizvodnji mikrobnih enzima za hidrolizu izdvojene frakcije galaktomanana do manooligosaharida (MOS) i manoze, kao i metodologija pročišćavanja proteina te karakterizacije oligo- i polisaharida. Ovisno o izdvojenom funkcionalnom sastojku, analizirat će se biološki učinci (antiglikacijski, prebiotički, antioksidacijski, citotoksični, genoprotektivni i protuupalni), kako bi se utvrdile učinkovite doze u daljnoj aplikaciji.Izdvojeni hidrofilni BAS inkapsulirat će se sušenjem raspršivanjem, elektrostatskom ekstruzijom, elektroispredanjem i liposomalno, pri čemu će se ispitati potencijal izdvojenih galaktomanana i/ili proteina kao nosača. Izdvojeni lipofilni BAS inkasulirat će se u liposome, ali i primijeniti u razvoju funkcionalnih oleogelova. Liposomalni sustavi hidrofilnih i lipofilnih BAS primijenit će se u razvoju stabilnih koinkapsuliranih sustava. U konačnici, novorazvijeni inkapsulirani sustavi i oleogelovi, MOS i manoza, inkorporirat će se u inovativne formulacije konditorskih proizvoda. Razvijeni inovativni integrirani pristup valorizaciji visokovrijednih sastojaka taloga i srebrne pokožice kave, uz procjenu održivosti primijenjenih postupaka, uvelike će doprinijeti daljnjem razvoju kružne ekonomije u industriji kave. ]]></summary_hr><summary_en><![CDATA[This project will focus on the development of innovative, integrated protocols for the valorization of spent coffee grounds and silverskin aiming to extract high-value ingredients, characterise their physico-chemical and biological properties and convert them into functional food ingredients. Innovative extraction techniques (microwaves, NADES, supercritical CO2) will be used to extract proteins, lipids and hydrophilic bioactive compounds (BAC), while alkaline hydrolysis with pretreatment (delignification, enzymatic or physical processes) will be used to extract galactomannan. New methodology using hydrolysates from coffee by-products will be developed to produce enzymes for the hydrolysis of isolated galactomannan into mannooligosaccharides (MOS) and mannose, as well as the methodology for protein purification and characterization of oligo- and polysaccharides. Depending on the isolated functional ingredients, the biological effects (antiglycation, prebiotic, antioxidant, cytotoxic, genoprotective and anti-inflammatory) will be analyzed to determine effective doses for further application. The hydrophilic BAC will be encapsulated by spray-drying, electrostatic extrusion, electrospinning and liposomes, by implementing isolated galactomannan and/or proteins as carriers. The isolated lipophilic BAC will be encapsulated in liposomes but also will be used in the development of functional oleogels. Liposomal systems of hydrophilic and lipophilic BAC will be used for the development of stable co-encapsulated systems. Ultimately, the newly developed encapsulated systems and oleogels, MOS and mannose, will be incorporated into innovative formulations of confectionery products. The innovative, integrated approach developed to valorize high-value components of spent coffee grounds and silverskin, together with an assessment of the sustainability of the applied processes, will contribute significantly to the further development of the circular economy in the coffee industry.]]></summary_en></project><project>
<id>17999</id><title_hr><![CDATA[Povezivanje ekološke uloge rastilišta i trofičkih obrazaca s dinamikom ribljih populacija i raznolikosti]]></title_hr><title_en><![CDATA[]]></title_en><user_id>2707</user_id><user_firstLast_name>Sanja Matić-Skoko</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-6742</code><acronim><![CDATA[LinkFish]]></acronim><duration>01.11.2025 - 31.10.2030</duration><status>U tijeku</status><financ_value>60,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut za oceanografiju i ribarstvo]]></institution_hr><institution_en><![CDATA[Institute of Oceanography and Fisheries]]></institution_en><team_members_id>872875</team_members_id><team_members_names><![CDATA[ Doktorand: Tonći Milardović ]]></team_members_names><keywords_hr><![CDATA[otolit, geokemija, stabilni izotopi, ekološka uloga, trofički odnosi, antropogeni pritisak, zajednica nedoraslih riba]]></keywords_hr><keywords_en><![CDATA[otolith, geochemistry, stable isotope, ecological role, trophic relationships, anthropogenic pressure, juvenile fish community]]></keywords_en><summary_hr><![CDATA[Određivanje vrijednosti obalnih rastilišta za obilje populacije i rast ekonomski važnih ili iskorištavanih vrsta je složen, ali kritično potreban zadatak. Kondicija nedorasle jedinke je odraz rasta i rezultat je stresa u okolišu, ekoloških interakcija (ishrana i predacija) i aktivnosti. Međutim, staništa koja podržavaju dobro kondicionirane nedorasle jedinke mogu nesrazmjerno doprinositi obilju odraslih jedinki te je neophodna pouzdana kvantifikacija specifičnih demografskih stopa za rastilišta koja određuju povezanost između geografski odvojenih nedoraslih i odraslih jedinki. Nažalost, morski ekosustavi su degradirani do te mjere da neka kritična obalna staništa više nisu dostupna ili prikladna za pružanje funkcija rastilišta, ishrane ili reprodukcije, što je rezultiralo negativnim posljedicama na stanje i obnavljanje populacija. Pretpostavljamo da se nedorasle ribe ponašaju u skladu s adaptivnim donošenjem odluka kako bi izbjegle loše hidrografske uvjete, izgladnjivanje i predaciju. Radi testiranja, moramo identificirati mogućnosti preživljavanja nedoraslih riba i različite uvjete za rast u različitim staništima te utvrditi uspješnost identificiranih rastilišta u ispunjavanju funkcionalnih uloga. Predloženo istraživanje olakšat će razvoj novih analiza biološkog funkcioniranja  na razini ekosustava i antropogenog utjecaja u morskim i prijelaznim okolišima. Primjenjivat će se najnovije tehnike uzorkovanja te pažljive pripreme i obrade uzoraka. Za geokemijske analize otolita i analize stabilnih izotopa koristit će se sofisticirani alati i najnovija tehnologija. Analiza podataka će uključivati programiranje u R-u, ekološko modeliranje i korištenje suvremene višeparametarske analize. Opći cilj ovog projektnog prijedloga je pružiti osnovne informacije potrebne za definiranje nepoznanica koje su potrebne za kvantificiranje vrijednosti rastilišta za gospodarski iskorištavane vrste u obalnim zajednicama i ponuditi pomoć u definiranju ključnih staništa za zaštitu i obnovu.]]></summary_hr><summary_en><![CDATA[Determination of coastal nurseries value for population abundance and growth of economically important or exploited species, is a complex but critically needed task. Juvenile fish condition as reflection of growth is result of environmental stress, ecological interactions (e.g., diet and predation), and fish activity. However, habitats that support well-conditioned juveniles may disproportionately contribute to the adult stock and reliable quantification of nursery habitat speci?c demographic rates determining connectivity among geographically segregated juveniles and adults is necessary. Unfortunately, marine ecosystems have been degraded to the extent that some critical coastal habitats are no longer available or suitable to provide nursery, feeding or reproductive functions, resulting in negative consequences on production and renewal of populations. We hypothesise that fish behave in a manner consistent with adaptive decision-making to avoid poor hydrographic conditions, starvation and predation. In order to test this, we have to identify juveniles’ chance of survival and different conditions for growth in different habitats, and determine the success of identified nurseries in fulfilling their functional roles. Proposed research will facilitate the development of novel, ecosystem-level analyses of biological functioning and anthropogenic forcing in marine and transitional environments. The latest techniques of sampling, careful sample preparation and processing will be applied. For otolith geochemistry and stable isotope analysis sophisticated tools and the latest technology will be used. Data analysis will include programming in R, ecological modelling and use of modern multiparameter analysis. The overall goal of the present project proposal is to provide baseline information needed to define knowledge gaps for quantifying the nursery value for exploited fish in coastal communities and offer aid in defining key habitats for protection and restoration.]]></summary_en></project><project>
<id>18000</id><title_hr><![CDATA[Metrička svojstva grafova]]></title_hr><title_en><![CDATA[]]></title_en><user_id>26632</user_id><user_firstLast_name>Snježana Majstorović Ergotić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-1688</code><acronim><![CDATA[MetGraph]]></acronim><duration>01.11.2025 - 31.10.2031</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Fakultet primijenjene matematike i informatike]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, School of Applied Mathematics and Informatics]]></institution_en><team_members_id>872877</team_members_id><team_members_names><![CDATA[ Doktorand: Robert Ledenčan ]]></team_members_names><keywords_hr><![CDATA[Grafovska metrika, metrička svojstva, Šoltésov problem, metrička dimenzija, metalne kocke, Horadamove kocke, Horadam-Lucasove kocke]]></keywords_hr><keywords_en><![CDATA[Graph metric, metric properties, Šoltés problem, metric dimension, metallic cubes, Horadam cubes, Horadam-Lucas cubes]]></keywords_en><summary_hr><![CDATA[Grafovske metrike i njihova proširenja iznimno su važni za razumijevanje strukturnih svojstava kompleksnih mreža. Primjerice, ako koristimo graf za modeliranje računalne mreže, onda udaljenost između njegovih vrhova predstavlja vrijeme potrebno za međusobnu komunikaciju odgovarajućih procesora. Ovaj koncept je koristan pri procjeni statistike vremena povezane s distribuiranim računarstvom. Za istraživanje i predviđanje korelacije struktura-svojstvo organskih spojeva u kemiji, potrebno je razumjeti međuatomske udaljenosti u pridruženom molekularnom grafu.Cilj ovog projekta je analiza metričkih svojstava grafova, posebno proučavanje problema temeljenih na udaljenostima među vrhovima u kontekstu različitih grafovskih metrika, njihovih poopćenja i proširenja. Jedan smjer istraživanja odnosi se na proučavanje Šoltesovih problema na grafovima vezanih uz poznate grafovske metrike te s udaljenosti toka, koja je neistražena grafovska ultrametrika. U takvim problemima će biti istražena osjetljivost grafovskih invarijanti, poput Wienerova indeksa, Kirchhoffova indeksa, indeksa toka i k-tog Steiner-Wienerova indeksa na male promjene u grafu. Slična istraživanja bit će provedena na usmjerenim grafovima uzimajući u obzir različite digrafovske metrike i njihova proširenja. Potencijalna primjena ovakvih istraživanja je u problemima otpornosti kompleksnih mreža. Drugi smjer istraživanja odnosi se na metričku dimenziju grafa, invarijantu koja se danas uglavnom koristi u raznim vrstama kompleksnih mreža te u robotici. Bit će istraženi problemi vezani uz različite vrste metričkih dimenzija te će biti razvijen heuristički algoritam za računanje metričke dimenzije grafa. Bit će istražena i veza između metričke dimenzije i spektra razdaljinske Laplaceove matrice. Nadalje, analizirat će se strukturna i metrička svojstva metalnih, Horadamovih te Horadam-Lucasovih kocaka, koje su nedavno uvedene familije grafova.]]></summary_hr><summary_en><![CDATA[Graph metrics and their extensions are of great importance for understanding the structural properties of complex networks. For example, if a graph is being used to model a computer network, the distance between vertices represents the time required for the corresponding processors to communicate with each other. This concept is useful when estimating timing statistics associated with distributed computing. In chemistry, to investigate and predict the structure-property correlation of organic compounds, one must understand the interatomic distances in the associated molecular graph. The goal of this project is the analysis of metric properties of graphs, in particular the study of distance-based problems on graphs in the context of different graph metrics, their generalizations and extensions. One research direction includes the study of Šoltés problems on graphs related to the well-known graph metrics and flow distance, an unexplored graph ultrametric. In these problems, the sensitivity of graph invariants such as the Wiener index, the Kirchhoff index, the flow index, and the k-th Steiner Wiener index to small changes in a graph is investigated. Similar studies will be conducted on digraphs by considering various digraph metrics and their extensions. Possible applications of these studies lie in the investigation of the resilience of complex networks.Another line of research focuses on the metric dimension of a graph, an invariant that is nowadays mainly used in various types of complex networks and robotics. Problems related to the different types of metric dimensions will be investigated and a heuristic algorithm for computing the metric dimension will be developed. The connection between the metric dimension and the spectrum of distance Laplacian matrix will be explored.Furthermore, the structural and metric properties of metallic, Horadam, and Horadam-Lucas cubes, recently introduced families of graphs will be analyzed. ]]></summary_en></project><project>
<id>18002</id><title_hr><![CDATA[Nanoplastika i mikroalge: nanostrukturni, nanomehanički i fiziološki odgovor]]></title_hr><title_en><![CDATA[Nanoplastics and microalgae: Unraveling nanostructural, nanomechanical and physiological responses]]></title_en><user_id>6101</user_id><user_firstLast_name>Tea Mišić Radić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-7932</code><acronim><![CDATA[AlgaNanoPlast]]></acronim><duration>05.12.2025 - 04.12.2028</duration><status>U tijeku</status><financ_value>195.500,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Interdisciplinarne prirodne znanosti, Fizika, Kemija, Biologija, </scie_field_hr><scie_field_en>Interdisciplinary natural sciences, Physics, Chemistry, Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>691, 513, 12729, 858380, 867754, 870062, 870050, </team_members_id><team_members_names><![CDATA[Petra Vukosav, Nadica Ivosevic DeNardis, Petra Peharec Štefanić, Bruno Komazec, Cecile Formosa, Adriana Contreras Sanchez, Simona Sebastiano, ]]></team_members_names><keywords_hr><![CDATA[morski ekosustav, mikroalge, nanomehanička svojstva, nanoplastika, nanostruktura, oksidativni stres, fotosinteza, fiziološki odgovor, polistiren]]></keywords_hr><keywords_en><![CDATA[marine ecosystem, microalgae, nanomechanics, nanoplastics, nanostructure, oxidative stress, photosynthesis, physiological response, polystyrene]]></keywords_en><summary_hr><![CDATA[Nanoplastika je široko rasprostranjena u okolišu te predstavlja značajnu prijetnju ekosustavu. Prisutnost nanoplastike u morskom okolišu zabrinjavajuća je zbog njenog utjecaja na morsku biotu, uključujući mikroalge, koje spadaju među najvažnije primarne proizvođače u morskim ekosustavima i čine temelj morskog hranidbenog lanca. Posljednjih godina istraživanja potencijalnog utjecaja nanoplastike u okolišu su u porastu, međutim, ekotoksikološki učinci nanoplastike na morske mikroalge rijetko su istraživani. Cilj projekta AlgaNanoPlast je istražiti utjecaj polistirenske nanoplastike (PS NPs) na nanostrukturni, nanomehanički i fiziološki odgovor mikroalgi. U okviru projekta istražit ćemo učinke PS NPs (nove eng. pristine i izložene procesu starenja eng. artificially-aged) s različitim površinskim nabojem i različitih veličina na dvije odabrane vrste morskih mikroalgi: dijatomeju Cylindrotheca closterium i zelenu algu Dunaliella tertiolecta. Utjecaj PS NPs na odabrane mikroalge proučavat ćemo na razini populacije i na razini pojedine stanice, što će uključivati praćenje inhibicije rasta, promjena nanostrukturnih i nanomehaničkih svojstava stanica, mjerenje odgovora na oksidativni stres, te mjerenje efekta na fotosintezu. S obzirom na ključnu ulogu mikroalgi u hranidbenom lancu i funkcioniranju morskog ekosustava, rezultati projekta AlgaNanoPlast značajno će doprinijeti razumijevanju utjecaja nanoplastike na cijeli morski ekosustav.]]></summary_hr><summary_en><![CDATA[Nanoplastics are pervasive pollutants in the environment and pose a significant threat to the health of ecosystems. Their presence in the marine environment raises concerns about their impact on marine biota, including microalgae, which are important primary producers in marine ecosystems and form the basis of the marine food web. While research on the potential environmental impacts of nanoplastics has increased in recent years, the ecotoxicological effects of nanoplastics on marine microalgae have been rarely studied. Our AlgaNanoPlast project aims to investigate the effects of polystyrene nanoplastics (PS NPs) on the nanostructural, nanomechanical and physiological responses of microalgae. We will investigate the effects of PS NPs (both pristine and artificially aged) with different surface charges and sizes on two selected marine microalgae species: the diatom Cylindrotheca closterium and the green alga Dunaliella tertiolecta. The response of the selected microalgae to nanoplastics will be studied at both the population and single-cell level. This will include monitoring growth inhibition, changes in the nanostructural and nanomechanical properties of the cells, measuring the response to oxidative stress and assessing the effects on photosynthetic activity. Given the crucial role of microalgae in the marine food web and ecosystem functioning, the results of the AlgaNanoPlast project will contribute significantly to the understanding of the ecological impact of nanoplastics on the entire marine ecosystem.]]></summary_en></project><project>
<id>18004</id><title_hr><![CDATA[Ekstrahiranje kvantnog: frustracija, neuređenost i uređaji]]></title_hr><title_en><![CDATA[Mining the quantum: frustration, disorder, and devices]]></title_en><user_id>20277</user_id><user_firstLast_name>Fabio Franchini</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-1667</code><acronim><![CDATA[MiQuaFruDaD]]></acronim><duration>19.01.2026 - 18.01.2029</duration><status>U tijeku</status><financ_value>197.783,33 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>866204, 865300, 868021, 870553, 26810, </team_members_id><team_members_names><![CDATA[Ryan Requist, Gianpaolo Torre, Antonio Štrkalj, Dario Živković, Salvatore Marco Giampaolo, ]]></team_members_names><keywords_hr><![CDATA[Frustracija, Kvantno računalstvo, Kvantna baterija, Kvantna spinska stakla, Lokalizacija, Neuređenost, Spinski lanci, Kvantna složenost]]></keywords_hr><keywords_en><![CDATA[Frustration, Quantum Computing, Quantum Battery, Quantum Spin Glass, Localization, Disorder, Spin chains, Quantum Complexity]]></keywords_en><summary_hr><![CDATA[Ovaj projekt ima za cilj unaprijediti naše razumijevanje i kontrolu kvantnih efekata u mnogotjelesnim, snažno koreliranim sustavima. Fokusirat ćemo se na tri međusobno povezana smjera istraživanja, sve vezana uz novi fazu kvantne tvari poznatu kao Topološka Frustracija (TF), koja se odlikuje osnovnim stanjima koja sadrže pojedinačne, frakcionalizirane, topološka uzbuđenja.Prvo ćemo primijeniti nedavno uvedeni mjerač kvantne kompleksnosti za proučavanje TF u različitim realizacijama, produbljujući naše razumijevanje kvantnih prednosti ovog stanja. U drugom paketu radnih zadataka, iskoristit ćemo svojstva TF sustava za dizajn novih kvantnih tehnologija. To uključuje razvoj kvantnih baterija koje nadmašuju nefrustrirane ekvivalentne i stvaranje metoda za ne-lokalno kodiranje kvbita, štiteći ih od lokalnog šuma. Ovi sustavi mogu se koristiti za kvantnu memoriju ili računanje, a mi ćemo procijeniti njihove prednosti i ograničenja.Na kraju, istražit ćemo kombinaciju TF i nesmetanosti kako bismo analizirali nastale faze. Preliminarni rad sugerira da nesmetanost može inducirati mnogotjelesnu lokaliziranu fazu, što nam omogućuje proučavanje dugoročnih interakcija. U drugim slučajevima, ona dovodi do amorfne faze s karakteristikama tipičnim za kvantni spin staklo. Za razliku od tradicionalnih modela kvantnog spin stakla, koji su složeni i teško ih je obraditi u velikim sustavima, modeli temeljen na TF su jednostavniji i obradivi. Ovo otvara nove mogućnosti za proučavanje ovog intrigantnog i neuhvatljivog kvantnog stanja.]]></summary_hr><summary_en><![CDATA[This project aims to advance our understanding and control of quantum effects in many-body, strongly correlated systems. We will focus on three interconnected research directions, all related to a novel phase of quantum matter called Topological Frustration (TF), which is characterized by ground states hosting single, fractionalized, topological excitations.First, we will apply a recently introduced measure of quantum complexity to study TF in different realizations, deepening our understanding of its quantum advantage. In the second work package, we will use the properties of TF systems to design new quantum technologies. This includes developing quantum batteries that outperform non-frustrated counterparts and creating methods to encode qubits non-locally, protecting them from local noise. These systems can be applied to quantum memory or computation, and we will evaluate their merits and limitations.Finally, we will investigate the combination of TF and disorder to analyze the resulting phases. Preliminary work suggests that disorder can induce a many-body localized phase, allowing us to study long-range interactions. In other cases, it leads to an amorphous phase with properties typical of a quantum spin glass. Unlike traditional quantum spin glass models, which are complex and difficult to handle in large systems, TF-based models are simpler and more tractable. This opens new possibilities for studying this intriguing and elusive quantum state.]]></summary_en></project><project>
<id>18006</id><title_hr><![CDATA[Biofortifikacija soje i suncokreta s jodom]]></title_hr><title_en><![CDATA[Biofortification of soybean and sunflower with iodine]]></title_en><user_id>870387</user_id><user_firstLast_name>Antonela Markulj Kulundžić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2025-02</proposal_call><code>UIP-2025-02-2305</code><acronim><![CDATA[BioSSI]]></acronim><duration>19.02.2026 - 18.02.2031</duration><status>U tijeku</status><financ_value>256.841,00 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, Interdisciplinarne biotehničke znanosti, </scie_field_hr><scie_field_en>Agriculture, Interdisciplinary biotechnical sciences, </scie_field_en><institution_hr><![CDATA[Poljoprivredni institut Osijek]]></institution_hr><institution_en><![CDATA[Agricultural Institute Osijek]]></institution_en><team_members_id>22492, 870519, 870783, 870555, </team_members_id><team_members_names><![CDATA[Ana Vuković Popović, Goran Herman, Nataša Lukić, Marija Vidovic, ]]></team_members_names><keywords_hr><![CDATA[Fiziološka, biokemijska i agronomska svojstva, folijarna prihrana, nusproizvod, održivost]]></keywords_hr><keywords_en><![CDATA[Physiological, biochemical and agronomic properties, foliar fertilization, byproduct, sustainability]]></keywords_en><summary_hr><![CDATA[Soja i suncokret se zbog svojih nutritivnih svojstava široko upotrebljavaju u prehrambenoj industriji. Nakon ekstrakcije ulja, kao nusproizvod se stvara sačma, koja je bogata proteinima te se koristi kao stočna hrana sa sve većim udjelom primjene i u ljudskoj prehrani. Jod je esencijalni element u tragovima ključan za regulaciju metabolizma, rast i razvoj. Nedovoljna količina joda uzrokuje brojne zdravstvene probleme kod ljudi i životinja. S druge strane, globalne klimatske promjene predstavljaju prijetnju poljoprivredi, uzrokujući stres na biljkama koji smanjuje prinose. Prilagodba agrotehničkih mjera, poput upotrebe bespilotnih letjelica (UAV) i biostimulansa, ključna je za održavanje produktivnosti usjeva. Projekt BioSSI nastoji razviti održiva poljoprivredna rješenja kroz biofortifikaciju soje i suncokreta jodom, čime se povećava koncentracija joda u zrnu i sačmi te se time unapređuje prehrana ljudi i životinja. Istraživanje obuhvaća sorte soje i hibride suncokreta s ciljem identifikacije genotipova sklonih nakupljanju joda. Provođenjem poljskih istraživanja u kojima ćemo soju i suncokret tretirat s folijarnom primjenom kalij jodata (KIO3), primijenjenim UAV osigurati ćemo ravnomjernu i preciznu distribuciju joda. Terenska analiza uključivat će praćenje vitalnosti biljaka, uz procjenu agronomskih parametara. Laboratorijski dio obuhvatit će analize listova, zrna, sačme i ulja. Provest će se određivanje koncentracije joda i ostalih elemenata, analiza biokemijskih markera oksidativnog stresa, sadržaja fotosintetskih pigmenata te sekundarnih metabolita. Kvaliteta ulja i sačme bit će ocijenjena prema standardima, čime će se dodatno potvrditi učinkovitost biofortifikacije. Obogaćena sačma s jodom, kao nusproizvod prerade ulja nastalo u ovom projektu, donijet će dodatnu vrijednost usklađenu s principima cirkularne ekonomije te doprinosi ciljevima održivog razvoja. Rezultati dobiveni BioSSI projektom koristit će poljoprivrednim proizvođačima i prehrambenoj industriji.]]></summary_hr><summary_en><![CDATA[Soy and sunflowers are widely used in the food industry due to their nutritional properties. After oil extraction, a byproduct meal is formed, rich in protein and used as an animal feed with an increasing share of application in human nutrition. Iodine is an essential trace element for regulating metabolism, growth and development. Insufficient iodine causes numerous health problems in humans and animals. On the other hand, global climate change threatens agriculture, causing stress on plants that reduce yields. Adaptation of agrotechnical measures, such as using UAVs and biostimulants, is crucial for maintaining crop productivity. The BioSSI project seeks to develop sustainable agricultural solutions through the biofortification of soy and sunflowers with iodine, which increases the iodine concentration in the grain and meal and thus improves the nutrition of humans and animals. The research includes soy varieties and sunflower hybrids to identify genotypes prone to iodine accumulation. By conducting field research in which we will treat soy and sunflowers with foliar application of potassium iodate, we will ensure an even and precise distribution of iodine by applying UAV. Field analysis will include monitoring plant vitality, along with an assessment of agronomic parameters. The laboratory part will consist of analyses of leaves, grains, meal and oil. Determination of iodine concentration and other elements, biochemical markers of oxidative stress analysis, photosynthetic pigment content and secondary metabolites will be done. The quality of oil and meal will be assessed according to standards, which will further confirm the effectiveness of biofortification. As a byproduct of oil processing created in this project, the iodine-enriched meal will bring added value that aligns with the circular economy principles and contributes to sustainable development aims. The results obtained by the BioSSI project will benefit agricultural producers and the food industry.]]></summary_en></project><project>
<id>18008</id><title_hr><![CDATA[Inaktivacija osteoklastnih progenitora i zaštita kosti u imunosno-posredovanim upalnim bolestima: modeli šećerne bolesti i artritisa]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3075</user_id><user_firstLast_name>Danka Grčević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-2318</code><acronim><![CDATA[OPTIMIDAL]]></acronim><duration>15.11.2025 - 14.11.2031</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>872948</team_members_id><team_members_names><![CDATA[ Doktorand: Ozana Jakšić ]]></team_members_names><keywords_hr><![CDATA[osteoklastni progenitori, šećerna bolest tipa 1, reumatoidni arthritis, mišji modeli, ljudski uzorci, trangenični miševi, razgradnja kosti]]></keywords_hr><keywords_en><![CDATA[osteoclast progenitors, type 1 diabetes, rheumatoid arthritis, mouse models, human samples, transgenic mice, bone resorption]]></keywords_en><summary_hr><![CDATA[Osteoklasti su stanice hematopoetskog podrijetla koje razgrađuju kost. Pojačana razgradnja kosti povezana je s brojnim imunosno-posredovanim upalnim bolestima (IMID), uključujući šećernu bolest tipa 1 (T1D) i reumatoidni artritis (RA). Unatoč tome, molekularni i stanični mehanizmi gubitka kosti i osteoporoze povezane s IMID-ima nisu u potpunosti istraženi. Usporednim istraživanjem mišjeg i ljudskog T1D i RA, cilj nam je otkriti mehanizme aktivacije osteoklasta, u skladu sa suvremenom preporukom da se dosadašnja organski-specifična klasifikacija IMID-a preinači u molekularnu.Naša hipoteza je da periferni osteoklastni progenitori koji izražavaju kemokinske receptore doprinose imunoporozi povezanoj s IMID-ima, zbog njihovog privlačenja na površinu kosti kemokinskim gradijentom i funkcionalne aktivacije izazvane upalom. Stoga očekujemo da uklanjanje definirane subpopulacije osteoklastnih progenitora, pomoću sustava Cre-DTA (podjedinica A difterijskog toksina), može spriječiti gubitak kosti u mišjim modelima T1D i RA. Nadalje, cilj nam je razjasniti zajedničke i specifične mehanizme aktivacije osteoklasta u miševa i bolesnika s T1D i RA.Koristit ćemo streptozotocinski (STZ) mišji model T1D te uzorke periferne krvi bolesnika s T1D. Višestruke niske doze STZ potiču inzulitis i upalne medijatore, vjerodostojno prikazujući patofiziologiju T1D. Analizirat ćemo fenotip, učestalost i aktivnost osteoklastnih progenitora te razgradnju kosti u miševa i ljudi s T1D. Usporedno određivanje profila aktivirajućih receptora na osteoklastnim progenitorima i osteoklastogenog okoliša kod T1D i RA otkrit će zajedničke i za bolest specifične mehanizme aktivacije osteoklasta. Nadalje, testirat ćemo može li DTA-posredovano uklanjanje perifernih CX3CR1+ osteoklastnih progenitora spriječiti osteoporozu, i, suprotno, može li prijenos označenih CX3CR1+ osteoklastnih progenitora poništiti tu zaštitu. Naši rezultati mogu pružiti važna saznanja za razvoj novih osteoprotektivnih tretmana IMID-a.]]></summary_hr><summary_en><![CDATA[Osteoclasts are hematopoietically-derived exclusive bone resorbing cells. Enhanced bone resorption is associated with a number of immune-mediated diseases (IMIDs), including type 1 diabetes (T1D) and rheumatoid arthritis (RA). Nevertheless, molecular and cellular mechanisms of bone loss and osteoporosis in IMIDs are still not fully explored. By parallel investigation of mouse and human T1D and RA, we aim to reveal mechanisms underlying osteoclast activation, in line with the recent intention to reframe organ-based to molecular-based classification of clinically divers IMIDs. We hypothesized that chemokine receptor-expressing peripheral osteoclast progenitors contribute to immunoporosis associated with IMIDs, through their chemokine-driven attraction to bone surfaces and inflammation-induced functional activation. Thus, we expect that ablation of defined subset of osteoclast progenitors, using the Cre-DTA (diphtheria toxin subunit A) system, may prevent bone loss in mouse T1D and RA. Moreover, we aim to resolve common and disease-specific mechanisms of osteoclast activation in mouse and human T1D and RA. We will use streptozotocin (STZ) mouse model of T1D and peripheral blood samples of T1D patients. Multiple low doses of STZ induce insulitis and inflammatory mediators, reliable modeling pathophysiology of T1D. We would assess phenotype, frequency and activity of osteoclast progenitors and bone resorption in mouse and human T1D. Comparative profiling of activating receptors on osteoclast progenitors and osteoclastogenic milieu in T1D and RA would reveal disease-specific and common mechanisms of osteoclast activation. Finally, we will test if DTA-mediated ablation of peripheral CX3CR1+ osteoclast progenitors may prevent osteoporosis, and, contrary, if transfer of labeled CX3CR1+ osteoclast progenitors would reverse this protection. Our results may provide important insights for the development of novel bone-protective treatments in IMIDs.]]></summary_en></project><project>
<id>18009</id><title_hr><![CDATA[Ex vivo/in vitro model za procjenu učinkovitosti onkolitičke viroterapije]]></title_hr><title_en><![CDATA[]]></title_en><user_id>102</user_id><user_firstLast_name>Beata Halassy</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-5746</code><acronim><![CDATA[MOVE]]></acronim><duration>20.04.2026 - 19.04.2032</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Interdisciplinarno područje znanosti</scie_area_hr><scie_area_en>Interdisciplinary scientific area</scie_area_en><scie_field_hr>Biotehnologija u biomedicini, </scie_field_hr><scie_field_en>Biotechnology in Biomedicine, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu]]></institution_hr><institution_en><![CDATA[University of Zagreb]]></institution_en><team_members_id>874034</team_members_id><team_members_names><![CDATA[ Doktorand: Lucija Ivandić ]]></team_members_names><keywords_hr><![CDATA[onkolitička viroterapija, virus ospica, virus zaušnjaka, virus vezikularnog stomatitisa, rak dojke, ex vivo/in vitro model]]></keywords_hr><keywords_en><![CDATA[oncolytic virotherapy, measles virus, mumps virus, vesicular stomatitis virus, breast cancer, ex vivo/in vitro model]]></keywords_en><summary_hr><![CDATA[Imunoterapija onkolitičkim virusima (OVT) je terapijski pristup liječenju raka u kojem se koriste virusi sa sposobnošću replikacije selektivnost u tumorskim tkivima. Oni ubijaju tumorske stanice in situ, oslobađaju tumorske antigene i potiču razvoj imuniteta specifičnog za tumor, iako identitet tumorskih antigena nije poznat, djelujući tako poput antigen-agnostičkih cjepiva. Unatoč velikom broju pretkliničkih znanstvenih dokaza koji pokazuju učinkovitost onkolitičkih virusa (OV) u suzbijanju tumora, OVT još nije dosegnula svoj puni potencijal u kliničkoj upotrebi, budući da rezultati kliničkih ispitivanja često ne odražavaju očekivanja temeljena na pretkliničkim podacima. Trenutni pretklinički in vitro modeli (tumorske stanične linie) i in vivo modeli (miševi s mišjim tumorima i miševi s presađenim ljudskim tumorima) su se pokazali neprikladnima za predviđanje učinkovitosti i sigurnosti kod ljudi. S ekspertizom u virologiji i imunologiji virusa ospica, zaušnjaka i vezikularnog stomatitisa, koji svi pripadaju obećavajućim platformama onkolitičkih virusa u razvoju, tražit ćemo pouzdanu metodologiju koja bi mogla odgovoriti je li tumor pojedinog pacijenta osjetljiv na ove viruse. Predložena metodologija temelji se na kratkotrajnom in vitro uzgoju tkiva raka dojke u 2D i 3D formatu, kontroliranom infekcijom s OV-ima i traženju pokazatelja replikacije virusa unutar tumorskog tkiva. Uspjeh u uspostavljanju takvog ex vivo/in vitro modela može približiti ovu novu imunoterapiju primjeni i pružiti osnovu za personalizaciju budućeg onkolitičkog liječenja malignih bolesti.]]></summary_hr><summary_en><![CDATA[Oncolytic virus immunotherapy (OVT) is a therapeutic approach to cancer treatment in which viruses with selective replication ability in tumor tissues are utilized. They kill tumor cells in situ, release tumor antigens, and promote the development of tumor-specific immunity, even though the identity of tumor antigens is unknown, thus acting as antigen-agnostic vaccines. Despite a large body of preclinical scientific evidence demonstrating the efficacy of oncolytic viruses (OV) in tumor suppression, OVT has not yet fully realized its potential in clinical use, as clinical trial results often do not align with expectations based on preclinical data. Current preclinical in vitro models (tumor cell lines) and in vivo models (mice with murine tumors and mice with transplanted human tumors) have proven inadequate for predicting efficacy and safety in humans. With expertise in virology and immunology of measles virus, mumps virus, and vesicular stomatitis virus, all of which belong to promising oncolytic virus platforms under development, we will seek a reliable methodology to determine whether an individual patient&#39;s tumor is susceptible to these viruses. The proposed methodology is based on short-term in vitro cultivation of breast cancer tissue in 2D and 3D formats, controlled infection with OV, and identification of markers of virus replication within the tumor tissue. Success in establishing such an ex vivo/in vitro model could bring this new immunotherapy closer to application and provide a foundation for personalizing future oncolytic treatments for malignant diseases.]]></summary_en></project><project>
<id>18010</id><title_hr><![CDATA[Razvoj fotokatalizatora aktivnih pod Sunčevim zračenjem i njihova primjena za razgradnju onečišćivala od posebne važnosti]]></title_hr><title_en><![CDATA[Tailored solar-active materials for photocatalytic degradation of contaminants of emerging concern]]></title_en><user_id>984</user_id><user_firstLast_name>Hrvoje Kušić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-8507</code><acronim><![CDATA[SOL-MAT-CLEAN]]></acronim><duration>01.12.2025 - 30.11.2028</duration><status>U tijeku</status><financ_value>199.745,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Kemijsko inženjerstvo, </scie_field_hr><scie_field_en>Chemical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet kemijskog inženjerstva i tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Chemical Engineering and Technology]]></institution_en><team_members_id>1122, 1180, 25650, 864945, 869764, 3845, 865710, 3168, 870361, 867710, </team_members_id><team_members_names><![CDATA[Ana Lončarić Božić, Vladimir Dananić, Josipa Papac, Stefani Tonković, Sandra Romac, Urska Lavrencic Stangar, Bostjan Genorio Genorio, Panaghiotis Karamanis, Zongsu Wei, Suresh Kumar Pandey, ]]></team_members_names><keywords_hr><![CDATA[pročišćavanje vode, farmaceutici, perfluorirani spojevi, solarna fotokataliza, napredni materijali]]></keywords_hr><keywords_en><![CDATA[water purification, pharmaceuticals, perfluorinated compounds, solar photocatalysis, advanced heterojunction materials]]></keywords_en><summary_hr><![CDATA[Nužnost rješavanja problema onečišćenja voda, koji štetno utječu na ljudsko zdravlje i prirodne ekosustave, nameće imperativ primjene učinkovitih tehnologija za njihovo pročišćavanje. Trenutni uređaji za pročišćavanje otpadnih voda pokazali su ograničenu moć uklanjanja onečišćivala od posebne važnosti (CECs), koja između ostalih, uključuju farmaceutike i perfluorirane spojeve, stoga je nužna njihova nadogradnja učinkovitijim procesima u tercijarnom koraku pročišćavanja. U svjetlu današnjih nisko-energetskih zahtjeva, solarna fotokataliza čini se obećavajućom opcijom.Glavni cilj SOL-MAT-CLEAN projekta je razvoj fotokatalitičkih materijala prilagođenih i krojenih svojstava, koji su mogu učinkovito aktivirati pod Sunčevom energijom za iniciranje oksidativne i reduktivne razgradnje odabranih CEC-ova, iskorištavajući i poboljšavajući svojstva poluvodiča nano veličine sa ciljem suzbijanja rekombinacije fotogeneriranih nositelja naboja. U tu svrhu bit će primijenjeni heterospojevi koji posjeduju odgovarajuću veličinu zabranjene zone (<3,0 eV) te položaje valentnih i vodljivih vrpci (>2,4 odnosno <-0,33 eV): g-C3N4/SnS2, g-C3N4/In2O3, BiVO4/SnS2 i BiVO4/In2O3, te upareni s (reduciranim) grafen-oksidom i ugljikovim kvantnim točkama. Karakterizacija i procjena fotokatalizatora uključuje temeljitu analizu njihove strukture, površine i sastava, nanoorganizacije i morfologije, kristaliničnosti i poluvodičkih svojstava, dok će se optoelektronička svojstva predvidjeti računalnim pristupom, što će omogućiti njihovo prilagođavanje i krojenje. Fotokatalitička razgradnja provodit će se u šaržnom reaktoru s imobiliziranim fotokatalizatorima pod simuliranim Sunčevim zračenjem, istražujući kinetiku procesa te mehanizme i putove razgradnje, povezujući ih sa promjenama sumarnih pokazatelja kvalitete vode. Na temelju dobivenih spoznaja, primijenit će se protočni pilot reaktor, sa ciljem daljnjeg uvećanja solarne fotokatalize kao tehnologije obrade vode.]]></summary_hr><summary_en><![CDATA[The urgency to circumvent water pollution problems, detrimentally affecting human health and natural ecosystems, renders imperative the implementation of efficient technologies for water treatment. Common wastewater treatment plants showed limited removal of contaminants of emerging concern (CECs), including among others pharmaceuticals and perfluorinated compounds, thus requiring upgrade with more effective processes in the tertiary treatment step. In light of respecting the low energy consumption considerations, solar-driven photocatalytic treatment seems to be a promising option.The main goal of SOL-MAT-CLEAN proposal is developing of tailored photocatalytic materials that are effective in harvesting abundant Solar irradiation for initiation of oxidative and reductive degradation of selected CECs, leveraging and improving the properties of nano-sized semiconductors to suppress detrimental charge carrier recombination phenomena. In that purpose heterojunctions possessing suitable band gap (<3.0 eV) and positions of valence and conduction bands (>2.4 and <-0.33 eV, respectively): g-C3N4/SnS2, g-C3N4/In2O3, BiVO4/SnS2 and BiVO4/In2O3, will be applied and paired with (reduced) graphene-oxide and carbon quantum dots. The photocatalysts characterization and evaluation include thorough analysis of their structure, surface and composition, nano-organization and morphology, crystallinity, and semiconducting properties, while optoelectronic properties will be predicted by computational approach, enabling their tailoring. Solar-assisted photocatalytic degradation will be performed in batch mode with immobilized solar-active photocatalysts aiming at elucidating degradation mechanisms and pathways in relationship to changes in sum-water quality parameters. The flow through reactor will be applied as well, using selected photocatalysts based on performances from the batch experiments, aiming at further scale-up of studied water treatment technology.]]></summary_en></project><project>
<id>18016</id><title_hr><![CDATA[SensMonCT II (23NRM05)]]></title_hr><title_en><![CDATA[]]></title_en><user_id>20122</user_id><user_firstLast_name>Marko Katić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-8972</code><acronim><![CDATA[]]></acronim><duration>14.01.2026 - 13.01.2032</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, </scie_field_hr><scie_field_en>Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>873057</team_members_id><team_members_names><![CDATA[ Doktorand: Maša Milanović-Litre ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>18022</id><title_hr><![CDATA[Epistemička demokracija u digitalno doba]]></title_hr><title_en><![CDATA[]]></title_en><user_id>19830</user_id><user_firstLast_name>Ivan Cerovac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-5133</code><acronim><![CDATA[EDDD]]></acronim><duration>16.12.2025 - 15.12.2031</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filozofija, </scie_field_hr><scie_field_en>Philosophy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Filozofski fakultet u Rijeci]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>873023</team_members_id><team_members_names><![CDATA[ Doktorand: Hana Samaržija ]]></team_members_names><keywords_hr><![CDATA[Demokracija, pravednost, umjetna inteligencija, legitimnost, fake news]]></keywords_hr><keywords_en><![CDATA[Democracy, Justice, Artificial Intelligence, Legitimacy, Fake news]]></keywords_en><summary_hr><![CDATA[Projekt se bavi analizom utjecaja koji digitalne tehnologije imaju na procedure demokratskog odlučivanja i na njihovu sposobnost da stvaraju legitimne političke odluke. Polazeći od teorije epistemičke demokracije, proučava se kako digitalne tehnologije utječu na pravičnost demokratskih procedura, kao i na njihovu epistemičku kvalitetu. Projektom se sistematizira postojeće znanje, analizira se kako odrediti okvire relevantnih tema, te se proučava koje se moralne i epistemičke vrijednosti mogu koristiti za uspostavljanje relevantnih evaluativnih standarada. Ovi standardi pak omogućuju utvrditi koji su relevantni problemi i kako ih se treba definirati u političkom kontekstu. ]]></summary_hr><summary_en><![CDATA[This research focuses on the effects digital technologies have on democratic decision-making procedures and on their ability to produce legitimate political decisions. Building upon the theory of epistemic democracy, the research investigates how digital technologies affect both the fairness of democratic procedures and their epistemic values, i.e., their ability to produce quality outcomes. It systemizes the existing knowledge, analyzes how issues are framed, and investigates which moral and epistemic considerations can be used for establishing the relevant evaluative standards. These standards help us determine what the relevant problems are and how these problems should be defined and understood in a political context.]]></summary_en></project><project>
<id>18023</id><title_hr><![CDATA[Usporedba zdravstvenih biomarkera u ljudi s različitim prehrambenim navikama]]></title_hr><title_en><![CDATA[Health-related biomarkers&#39; comparison in people with different dietary habits]]></title_en><user_id>171</user_id><user_firstLast_name>Marko Gerić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-2823</code><acronim><![CDATA[UZDRAVLJe]]></acronim><duration>31.12.2025 - 30.12.2028</duration><status>U tijeku</status><financ_value>200.000,00 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, Javno zdravstvo i zdravstvena zaštita, </scie_field_hr><scie_field_en>Basic Medical Sciences, Public health and health services, </scie_field_en><institution_hr><![CDATA[Institut za medicinska istraživanja i medicinu rada]]></institution_hr><institution_en><![CDATA[Institute for Medical Research and Occupational Health]]></institution_en><team_members_id>87, 870472, 4575, 3911, 1288, 866664, 865031, 216, 870474, 865628, </team_members_id><team_members_names><![CDATA[Goran Gajski, Isabel Moreno Indias, Martina Bituh, Selma Cvijetić Avdagić, Marijana Vučić Lovrenčić, Luka Kazensky, Katarina Matković, Tatjana Orct, MANUEL MACIAS GONZALEZ, Maja Nikolić, ]]></team_members_names><keywords_hr><![CDATA[nutricionizam, biomarkeri, mikrobiom, epigenetika, javno zdravstvo]]></keywords_hr><keywords_en><![CDATA[nutritionism, biomarkers, microbiome, epigenetics, public health]]></keywords_en><summary_hr><![CDATA[Prehrana je komponenta ekspozoma koju je moguće vrlo lako mijenjati te je jedan od ključnih čimbenika u održavanju zdravlja i dobrobiti ljudi. Unatoč brojnim istraživanjima koja su pokazala dobrobiti različitih vrsta prehrane, rezultati o njihovom utjecaju na ljudsko zdravlje još uvijek nisu u potpunosti jednoznačni. Cilj projekta UZDRAVLJe jest usporediti različite prehrambene obrasce korištenjem multibiomarker pristupa (nutricionistička procjena, sastav tijela, oštećenja molekule DNA, analiza mikrobioma, biokemijski biomarkeri, epigenetika) na biološkim uzorcima ispitanika (N=200). Međunarodni multidisciplinarni tim za nutrigenomiku bavit će se problemom od nacionalne i globalne važnosti – utjecajem prehrane na zdravstvene biomarkere. Ishodi projekta uključuju rezultate koji će biti vrijedni za širu javnost, znanstvenu zajednicu, pravna tijela i industriju. Štoviše, projekt će poboljšati istraživačke kapacitete i uključivanje mladih istraživača u međunarodno relevantne projekte. Konačno, projekt UZDRAVLJe usmjeren je na poboljšanje zdravlja ljudi na temelju njihovih prehrambenih preferencija usklađujući se s tematskim prioritetom S3 personalizirana briga o zdravlju i podupirući okolišnu održivost Europskog zelenog plana.]]></summary_hr><summary_en><![CDATA[Diet is part of the human exposome that can be easily modified, yet it is one of the key factors in sustaining health and wellbeing. Despite thorough research describing the benefits of particular diet types, the results on their impact on human health are still inconclusive. UZDRAVLJe project aims to compare different dietary patterns using a multi-biomarker approach (nutritional profiling, body composition, baseline DNA damage, microbiome analysis, biochemical biomarkers, epigenetics) on a set of samples from human volunteers (N=200). An international multidisciplinary nutrigenomics team will tackle a problem of national and global relevance – diet-related impact on health biomarkers. The project’s outcomes include results that will interest the general public, the scientific community, legal bodies, and industry. Moreover, the project will improve capacity building and involvement of early career researchers in internationally relevant projects. Finally, the UZDRAVLJe project focuses on improving human health based on their dietary preferences aligning with S3 thematic priority personalized health care and supporting the environmental sustainability of the European Green Deal. ]]></summary_en></project><project>
<id>18026</id><title_hr><![CDATA[Ćirilične pismovne varijante u Hrvatskoj: paleografska raščlamba i evolucija pismenosti kroz povijest]]></title_hr><title_en><![CDATA[Cyrillic Script Variants in Croatia: Paleographic Analysis and the Evolution of Literacy Through History ]]></title_en><user_id>865501</user_id><user_firstLast_name>Kristian Paskojević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-5681</code><acronim><![CDATA[HRVĆIRPAL]]></acronim><duration>05.12.2025 - 04.12.2028</duration><status>U tijeku</status><financ_value>67.720,00 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Interdisciplinarne humanističke znanosti, Filologija, Povijest, </scie_field_hr><scie_field_en>Interdisciplinary humanities, Philology, History, </scie_field_en><institution_hr><![CDATA[Staroslavenski institut]]></institution_hr><institution_en><![CDATA[Old Church Slavonic Institute in Zagreb]]></institution_en><team_members_id>25202, 25841, 870586, 870627, 867880, 23406, </team_members_id><team_members_names><![CDATA[Josip Mihaljević, Neven Isailović, Kardaš Mehmed, Marko Brkljačić, Janja Dora Ivančić, Ivan Botica, ]]></team_members_names><keywords_hr><![CDATA[Hrvatska ćirilična pismenost, slavenska paleografija, povijest, filologija, digitalna humanistika]]></keywords_hr><keywords_en><![CDATA[Croatian Cyrillic literacy, Slavic palaeography, history, philology, digital humanities]]></keywords_en><summary_hr><![CDATA[Projekt će istražiti regionalne varijante ćirilične pismenosti u hrvatskoj povijesti kroz paleografsku analizu. Ciljevi uključuju identifikaciju, klasifikaciju i analizu korpusa ćiriličnih tekstova te publikaciju prikupljenih rezultata. Uporabom kombinacije tradicionalnih i modernih metodologija paleografskoga istraživanja, uključujući digitalnu analizu teksta i grafijsku klasifikaciju, projekt će pružiti interdisciplinarni uvid u evoluciju ćiriličnih varijanti i njihovu povezanost s kulturnim kontekstom. Očekivani rezultati uključuju znanstvenu monografiju, digitalnu latiničnu transliteraciju korpusa te izradu paleografskih (kronoloških i topografskih) digitalnih karata u GIS programu.]]></summary_hr><summary_en><![CDATA[The project will investigate regional variants of Cyrillic literacy in Croatian history through paleographic analysis. The goals include the identification, classification and analysis of the corpus of Cyrillic texts and the publication of the collected results. Using a combination of traditional and modern palaeographic research methodologies, including digital text analysis and graphic classification, the project will provide interdisciplinary insight into the evolution of Cyrillic variants and their connection to cultural context. The expected results include a scientific monography, a digital Latin transliteration of the corpus and the creation of paleographic (chronological and topographic) digital maps in the GIS program.]]></summary_en></project><project>
<id>18027</id><title_hr><![CDATA[Računalno modeliranje iskorištavanja otpadne topline na brodovima za krstarenje]]></title_hr><title_en><![CDATA[Computer modeling of waste heat utilization on cruise ships]]></title_en><user_id>21279</user_id><user_firstLast_name>Fran Torbarina</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2025-02</proposal_call><code>UIP-2025-02-3327</code><acronim><![CDATA[CoMWaHUCS]]></acronim><duration>05.12.2025 - 04.12.2030</duration><status>U tijeku</status><financ_value>127.648,85 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, Temeljne tehničke znanosti, </scie_field_hr><scie_field_en>Mechnical engineering, Basic engineering sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Pomorski fakultet ]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Maritime Studies]]></institution_en><team_members_id>19392, 870759, 24103, </team_members_id><team_members_names><![CDATA[Mateo Kirinčić, Josip Dujmovic, Vladimir Pelić, ]]></team_members_names><keywords_hr><![CDATA[otpadna toplina, računalno modeliranje, energetska učinkovitost, brodovi za krstarenje, trnsys]]></keywords_hr><keywords_en><![CDATA[waste heat, dynamic system simulations, energy efficiency, cruise ships, trnsys]]></keywords_en><summary_hr><![CDATA[U skladu s globalnim klimatskim sporazumima, Međunarodna pomorska organizacija donijela je smjernice za smanjenje emisija stakleničkih plinova i povećanje energetske učinkovitosti u pomorstvu. Posebno se ističu brodovi za krstarenje koji, unatoč relativno malom udjelu u pomorskom sektoru, imaju značajan utjecaj na emisije zbog visoke energetske potrošnje. Najveći potrošač energije na tim brodovima je pogonski sustav, dok pomoćni sustavi, poput HVAC-a, uređaja za proizvodnju sanitarne vode i ostali pomoćni sustavi također doprinose velikoj potrošnji.Jedan od ključnih pristupa poboljšanju energetske učinkovitosti je povećanje količine iskorištene otpadne topline koja nastaje uslijed rada generatorskih motora. Istraživanja su pokazala da pravilnim korištenjem otpadnom toplinom na brodovima za krstarenje može doći do značajnog smanjenja potrošnje energije, emisija CO2 i potrošnje goriva. Ovisno o njezinoj temperaturi, otpadna toplina može se koristiti za razne svrhe kao što su proizvodnja pare i električne energije u Rankineovom procesu, desalinizacija i predgrijavanje sanitarne vode, rad apsorpcijskih rashladnih uređaja i drugi. Ovo istraživanje nastoji proširiti postojeća znanja eksperimentalnim istraživanjem utjecaja razine opterećenja brodskih generatorskih motora na količinu otpadne topline i emisije CO2 i pronalaskom učinkovitih konfiguracija i strategija upravljanja sustavima za iskorištavanje otpadne topline s ciljem poboljšanja energetske učinkovitosti brodova za krstarenje te doprinošenja zelenoj tranziciji i postizanju održivog razvoja u pomorstvu.]]></summary_hr><summary_en><![CDATA[In accordance with global climate agreements, the International Maritime Organization has issued guidelines for reducing greenhouse gas emissions and increasing energy efficiency in the maritime sector. Cruise ships are particularly emphasized, as they have a significant impact on emissions due to high energy consumption, despite their relatively small share in the maritime industry. The main energy consumer on these ships is the propulsion system, while auxiliary systems such as HVAC, sanitary water production devices, and other auxiliary systems also contribute to overall energy consumption.  One of the key approaches to achieving higher energy efficiency is increasing the utilization of waste heat generated by engines. Research has shown that proper utilization of waste heat on cruise ships can lead to a significant reduction in total energy consumption, CO2 emissions, and fuel consumption. Depending on its temperature, waste heat can be used for various purposes, such as steam and electricity production in the Rankine cycle, desalination and preheating of sanitary water, operation of absorption refrigeration systems, and more.  This study aims to expand existing knowledge through experimental research on the impact of ship generator engine load levels on the amount of waste heat and CO2 emissions and it seeks to identify efficient configurations and management strategies for waste heat recovery systems to enhance the energy efficiency of cruise ships, contribute to the green transition, and support sustainable development in the maritime sector.]]></summary_en></project><project>
<id>18029</id><title_hr><![CDATA[Mikroorganizmi kao izvor novih klasa antibiotika – Od totalne sinteze do novog kemijskog prostora i metodologije	]]></title_hr><title_en><![CDATA[]]></title_en><user_id>12766</user_id><user_firstLast_name>Nikola Cindro</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-9631</code><acronim><![CDATA[]]></acronim><duration>12.01.2026 - 11.01.2032</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>873034</team_members_id><team_members_names><![CDATA[ Doktorand: Marin Knežević ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>18031</id><title_hr><![CDATA[Analiza interakcija organofosfornih spojeva s esterazama i mogućim metama terapije kod otrovanja]]></title_hr><title_en><![CDATA[]]></title_en><user_id>411</user_id><user_firstLast_name>Nikolina  Maček Hrvat</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-7746</code><acronim><![CDATA[OPEsterOX]]></acronim><duration>10.11.2025 - 09.11.2030</duration><status>U tijeku</status><financ_value>60,00 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Institut za medicinska istraživanja i medicinu rada]]></institution_hr><institution_en><![CDATA[Institute for Medical Research and Occupational Health]]></institution_en><team_members_id>872944</team_members_id><team_members_names><![CDATA[ Doktorand: Petar Nakić ]]></team_members_names><keywords_hr><![CDATA[acetilkolinesteraza, antidoti, butirillkolinesteraza, OPNA, reaktivacija, oksimi, organofosfati, toksičnost]]></keywords_hr><keywords_en><![CDATA[acetylcholinesterase, antidotes, butyrylcholinesterase, OPNA, reactivation, oximes, organophosphate, toxicity]]></keywords_en><summary_hr><![CDATA[Izloženost organofosfatima (OP) od kojih su neki pesticidi ili živčani bojni otrovi (ŽBO) dovodi do inhibicije enzima acetilkolinesteraze (AChE) ključnog za funkcioniranje živčanog sustava. Blokiranje aktivnosti izaziva kolinergičku krizu, odnosno pretjeranu stimulaciju muskarinskih i nikotinskih membranskih receptora u središnjem i perifernom živčanom sustav, što može dovesti do dugotrajnih posljedica trovanja pa i do smrti. Standardna terapija trovanja OP koja uključuje primjenu antimuskarinika, atropina i oksimskog reaktivatora AChE, nije učinkovita za različite OP, posebice nije za fosforoamidate radi strogo-strukturalno ovisnog mehanizma reaktivacije enzima. Alternativna terapija odnosi se na srodni enzim butirilkolinesterazu (BChE) koji veže OP spojeve u cirkulaciji i kao takav djeluje kao stehiometrijsko biočistilo OP. Stoga ovaj projekt koristi poznate (npr. tabun, metamidofos i fenamifos) i neistražene spojeve (A-seriju organofosfata) za bolje razumijevanje mehanizama interakcija kolinesteraza s fosforoamidatima s ciljem pronalaska učinkovitih načina terapije. Biokemijski mehanizam interakcija enzima sveobuhvatno će se proučavati na molekulskoj razini metodama in silico, in vitro i ex vivo kako bi se odredili afiniteti vezanja, brzine inhibicije i učinkovitost reaktivacije enzima. Mehanizmi toksičnosti odabranih OP studirat će se na staničnom nivou. Najučinkovitiji reaktivatori testirat će se kao antidoti na miševima izloženim OP. Također, na mišjem mozgu ispitat će se neuroinflamatorni učinak OP kao i neuroprotektivna djelotvornost oksimske terapije praćenjem specifičnih markera astroglioze, mikroglioze i vijabilnosti neurona. Ove sveobuhvatne analize doprinijet će neupitno poznavanju interakcija fosforoamidata i učinkovitije terapije u otrovanju s njima i sličnim OP.]]></summary_hr><summary_en><![CDATA[Exposure to organophosphates (OP) from both pesticides and nerve agents leads to the covalent inhibition of the pivotal enzyme acetylcholinesterase (AChE) that leads to accumulation of neurotransmitter acetylcholine, which induces cholinergic crisis, that is, overstimulation of muscarinic and nicotinic membrane receptors in the central and peripheral nervous system. In severe cases, subsequent desensitisation of the receptors results in hypoxia, vasodepression, and respiratory arrest, followed by death. Standard therapy of OP poisoning that generally involves administration of anticholinergic atropine and an oxime reactivator of phosphylated AChE has limitations especially in the case of phosphoroamidates due to the structural-related mechanism of reactivation. An alternative therapy is the related enzyme butyrylcholinesterase (BChE) which binds OP compounds and as such acts as stoichiometric bioscavenger of OP. Therefore, this project utilizes known (e.g. tabun, methamidophos and fenamiphos), and new compounds (A-agents) to gain a better understanding of the mechanistic basis of cholinesterase family interactions and their limitations to find new effective leads for treatment. The biochemical mechanism of enzyme interactions will be comprehensively studied on a molecular level with in silico, in vitro, and ex vivo methods to define binding affinities, kinetic constants of inhibition and efficiency of reactivation of both enzymes. The possible mechanisms of toxicity of selected OPs will be studied at cell-culture level, and on mice exposed to OP. The neuroinflammatory effect of OP as well as the neuroprotective effectiveness of oxime therapy will be examined on the mouse brain by monitoring specific markers of astrogliosis, microgliosis and neuron viability. These comprehensive analyses will undoubtedly contribute to the knowledge of phosphoroamidate interactions and improved therapeutics in OP poisoning.]]></summary_en></project><project>
<id>18032</id><title_hr><![CDATA[Izvanstanična superoksid-dismutaza i njezini antioksidacijski mehanizmi kod bolesnika s teškom traumatskom ozljedom mozga]]></title_hr><title_en><![CDATA[Extracellular Superoxide Dismutase and Its Antioxidative Mechanisms in Severe Traumatic Brain Injury Patients]]></title_en><user_id>6187</user_id><user_firstLast_name>Kristina Grabušić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-9700</code><acronim><![CDATA[ExSOD-sTBI]]></acronim><duration>05.12.2025 - 04.12.2028</duration><status>U tijeku</status><financ_value>194.554,00 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Medicine]]></institution_en><team_members_id>25472, 855416, 26195, 867721, 28652, </team_members_id><team_members_names><![CDATA[Janja Tarčuković, Siniša Zrna, Ksenija Tulić, Anton Bilić, Carmen Rožmanić, ]]></team_members_names><keywords_hr><![CDATA[cerebrospinalna tekućina, izvanstanične vezikule, neuroprotekcija, oksidacijski stres, ozljede mozga, superoksid-dismutaza]]></keywords_hr><keywords_en><![CDATA[Brain Injuries, Cerebrospinal Fluid, Extracellular Vesicles, Neuroprotection, Oxidative Stress, Superoxide Dismutase]]></keywords_en><summary_hr><![CDATA[Traumatska ozljeda mozga (TOM) nastaje kada fizička sila ošteti moždano tkivo, što može rezultirati spektrom oštećenja od blagih do teških, s potencijalno opasnim po život ili dugoročnim neurološkim posljedicama. Kritični izazov u liječenju akutnog TOM-a je njegova složena i dinamična intrakranijalna patofiziologija, gdje mehanizmi sekundarne ozljede—uključujući oksidacijski stres, neuro-upalu i ekscitotoksičnost—mogu značajno pogoršati ishod bolesnika nakon početne traume. Trenutne strategije liječenja u ranoj fazi nakon TOM-a usmjerene su na ublažavanje sekundarne ozljede. Za razvoj učinkovitijih neuroprotektivnih terapija neophodno je bolje razumijevanje oštećenja i procesa oporavka mozga.Prijedlog ExSOD-sTBI istražuje superoksid-dismutazu (SOD), presudnu enzimsku obranu od oksidacijskog stresa, središnjeg faktora sekundarne ozljede u TOM-u. Naše preliminarne analize cerebrospinalne tekućine (CST) pokazuju da teški TOM (tTOM) kod bolesnika uzrokuje značajne promjene u intrakranijalnim vrstama i razinama SOD-a. Nadalje, naša inicijalna istraživanja ukazuju na potencijalnu povezanost između SOD-a u CST-u i izvanstaničnih vezikula (IV)—bioloških nanočestica uključenih u međustaničnu komunikaciju i molekularni transport. ExSOD-sTBI ima za cilj istražiti svojstva izvanstaničnog SOD-a u CST-u bolesnika s tTOM-om. Da bismo to postigli, koristit ćemo napredne tehnike izolacije i karakterizacije IV-a, zajedno s proteinskim profiliranjem, kvantitativnim analizama i enzimskim testovima, kako bismo odredili izvanstanične oblike, katalitičku učinkovitost i stanično podrijetlo SOD-a u intrakranijalnom CST-u bolesnika s tTOM-om.Razjašnjavanjem uloge SOD-a i njegovih izvanstaničnih oblika u antioksidacijskom odgovoru mozga, ExSOD-sTBI će pridonijeti boljem razumijevanju regulacije oksidacijskog stresa kod tTOM-a. Ova otkrića mogu poslužiti kao temelj za buduća istraživanja o praćenju neuroprotekcije i antioksidativnih mehanizama kod bolesnika s ozljedom mozga.]]></summary_hr><summary_en><![CDATA[Traumatic brain injury (TBI) occurs when physical force damages the brain tissue, resulting in a spectrum of injuries ranging from mild to severe, with potentially life-threatening or long-term neurological consequences. A critical challenge in acute TBI management is its complex and dynamic intracranial pathophysiology, where secondary injury mechanisms—including oxidative stress, neuroinflammation, and excitotoxicity—can significantly worsen patient outcomes beyond the initial trauma. While current treatments in the early post-TBI phase focus on mitigating secondary injury, a deeper understanding of brain damage and recovery processes is essential for developing more effective neuroprotective strategies.The ExSOD-sTBI proposal investigates superoxide dismutase (SOD), a key enzymatic defence against oxidative stress, a major driver of secondary injury in TBI. Our preliminary analysis of cerebrospinal fluid (CSF) indicates that severe TBI (sTBI) in patients induces marked changes in intracranial SOD types and levels. Furthermore, our initial findings suggest a potential association between SOD in CSF and extracellular vesicles (EVs)—biological nanoparticles involved in intercellular communication and molecular transport. The ExSOD-sTBI project aims to assess the properties of extracellular SOD in the CSF of sTBI patients. To achieve this, we will employ advanced EV isolation and characterization techniques, along with protein profiling, quantitative analysis, and enzymatic assays, to determine the extracellular forms, catalytic efficacy, and cellular origin of SOD in intracranial CSF from patients with sTBI.By defining the role of extracellular SOD in the brain’s antioxidative response, ExSOD-sTBI will contribute to a better understanding of oxidative stress regulation in sTBI. These findings could inform future research on neuroprotection monitoring and antioxidative mechanisms in patients with brain injury.]]></summary_en></project><project>
<id>18038</id><title_hr><![CDATA[Dvostruka nevolja: Virusna infekcija u kontekstu bolesti steatotične jetre povezane s metaboličkom disfunkcijom]]></title_hr><title_en><![CDATA[]]></title_en><user_id>7082</user_id><user_firstLast_name>Bojan Polić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-2713</code><acronim><![CDATA[VICES]]></acronim><duration>02.02.2026 - 01.02.2032</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Medicine]]></institution_en><team_members_id>873094</team_members_id><team_members_names><![CDATA[ Doktorand: Lara Melvan ]]></team_members_names><keywords_hr><![CDATA[MASLD, MCMV, LCMV, IAV, stanice NK, stanice ILC, limfociti T, makrofagi]]></keywords_hr><keywords_en><![CDATA[MASLD, MCMV, LCMV, IAV, NK cells, ILCs, T cells, Macophages]]></keywords_en><summary_hr><![CDATA[Bolest masne jetre povezana s metaboličkom disfunkcijom (MASLD) smatra se jetrenom manifestacijom metaboličkog sindroma i pogađa gotovo polovicu svjetske odrasle populacije. MASLD obuhvaća niz kliničkih entiteta u rasponu od jednostavne steatoze do ciroze. MASLD je povezan s više poznatih komorbiditeta, no imunološka disfunkcija je i dalje slabo istražena. Epidemiološki podaci pokazuju da osobe s MASLD-om imaju znatno povećanu vjerojatnost obolijevanja  i smrtnosti od zaraznih bolesti, no osnovni mehanizam u pozadini istog je uglavnom nepoznat. Nedavno je moj tim pokazao da je ključni događaj u patofiziologiji MASLD-a razvoj imunosnog odgovora, obilježenog citokinom IL-17A, koji uzrokuje polariziranu upalu tipa 3 koja dovodi do fibroze jetre. Naši preliminarni nalazi pokazuju da upalno mikrookruženje u jetri uzrokovano MASLD-om narušava imunosni odgovor tipa 1 prilikom virusnih infekcija, što rezultira većom količinom virusnih čestica nakon infekcije. Glavni cilj ovoga projekta jest razjasniti kako MASLD remeti antivirusni imunosni odgovor. Korištenje mišjeg modela za MASLD razvijenog u mom laboratoriju razjasnit ćemo koja je faza antivirusnog imunosnog odgovora i koliko široko pogođena. Uz pomoć genetski modificiranih mišjih modela identificirat ćemo koji čimbenik izazvan MASLD-om posreduje ovaj učinak i koje su antivirusne imunološke stanice prvenstveno pogođene ovom metaboličkom bolešću. Koristit ćemo molekularno-biološke tehnike kako bismo okarakterizirati ključne unutarstanične čimbenike u imunosnim stanicama na koje utječe MASLD. Očekujemo da će ovaj projekt omogućiti dublje razumijevanje štetnog učinka koji MASLD ima na normalan antivirusni imunosni odgovor. S obzirom na vrlo visoku učestalosti MASLD-a u populaciji, naša otkrića bi mogla imati veliki utjecaj na buduće strategije u pogledu prevencije i liječenja zaraznih bolesti.]]></summary_hr><summary_en><![CDATA[MASLD comprises a range of clinical entities, ranging from simple steatosis to cirrhosis. MASLD is associated with several comorbidities, but immune disfunction has remained largely ignored. Epidemiological data indicates that people with MASLD have a strongly increased chance of morbidity and mortality because of infectious disease, but the underlying mechanism is unknown. Recently, my team has shown that a key event in the pathophysiology of MASLD is the development of an immune response, marked by the cytokine IL-17A, which causes a type-3 polarized inflammation that leads to liver fibrosis. Our preliminary findings indicate that the inflammatory microenvironment in the liver caused by MASLD impairs the type-1 immune response to viruses, leading to higher pathogen loads upon infection. The goal of this project is to elucidate how MASLD impairs the antiviral immune response. Using a dietary animal model for MASLD developed in my lab, we will elucidate which phase of the antiviral immune response is affected and how broadly the response is impacted. With advanced genetic models, we will identify which MASLD-induced factor mediates this effect and which antiviral immune cell is primarily impacted by this metabolic disease. Molecular biological techniques will be used to characterize the key intracellular factors affected by MASLD-induced inflammation in these immune cells. Thus, this project will provide deeper understanding of the detrimental effect that MASLD has on the normal antiviral immune response. Considering the frighteningly high incidence of MASLD in our society, our findings have great implications for future strategies with regards to prevention and treatment of infectious disease.]]></summary_en></project><project>
<id>18043</id><title_hr><![CDATA[Bihevioralna i računarska svojstva adaptivne raspodjele resursa radnog pamćenja]]></title_hr><title_en><![CDATA[Behavioural and computational properties of adaptive working memory resource allocation]]></title_en><user_id>869962</user_id><user_firstLast_name>Ivan Tomić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2025-02</proposal_call><code>UIP-2025-02-6353</code><acronim><![CDATA[COBRA]]></acronim><duration>19.02.2026 - 18.02.2031</duration><status>U tijeku</status><financ_value>284.059,76 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Psihologija, </scie_field_hr><scie_field_en>Psychology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>23586, 865735, 3953, </team_members_id><team_members_names><![CDATA[Marina Martinčević, Francesca Dumančić, Zlatko Hanić, ]]></team_members_names><keywords_hr><![CDATA[vidno radno pamćenje, adaptacija, efikasna obrada, bayesijansko zaključivanje, računarsko modeliranje, kognicija]]></keywords_hr><keywords_en><![CDATA[visual working memory, adaptation, efficient processing, Bayesian inference, computational modelling, cognition]]></keywords_en><summary_hr><![CDATA[Kako bi se osiguralo optimalno funkcioniranje, ljudski mozak i kognitivni procesi moraju se neprestano prilagođavati okolini. To je osobito važno za procese s ograničenim kapacitetima, kod kojih je optimalna raspodjela resursa ključna za uspješnu obradu informacija. Međutim, kada je riječ o radnom pamćenju – kognitivnom procesu iznimno ograničenog kapaciteta, ali neophodnom za svakodnevno funkcioniranje – još uvijek znamo malo o njegovoj sposobnosti brze prilagodbe strukturi okoline i optimalne uporabe resursa.Ovaj projekt istražuje kako statistička struktura okoline utječe na raspodjelu resursa ljudskog vidnog radnog pamćenja (VRP). Cilj je utvrditi pod kojim uvjetima VRP adaptivno prilagođava raspodjelu svojih resursa zahtjevima okoline te identificirati bihevioralne indikatore takve prilagodbe. Posebno ćemo ispitati vremensku dinamiku adaptacije i karakteristike okoline koje VRP može kodirati i uzeti u obzir pri raspodjeli resursa. Dodatno, primjenom računarnih modela populacijskog kodiranja istražit ćemo biološki plauzibilne neuralne mehanizme koji omogućuju prilagodbu i adaptivnu raspodjelu resursa.Rezultati ovog istraživanja imat će značajnu znanstvenu i primijenjenu vrijednost, s potencijalnim koristima za obrazovnu zajednicu te zdravstvene stručnjake koji rade s osjetljivim skupinama i razvijaju programe kognitivne rehabilitacije.]]></summary_hr><summary_en><![CDATA[To ensure optimal functioning, the human brain and cognitive processes must continuously adapt to the surrounding environment. This is particularly important for processes with limited capacities, where the optimal allocation of resources is crucial for successful information processing. However, when it comes to working memory - an extremely capacity-limited cognitive process that is essential for everyday functioning - we still know relatively little about its ability to rapidly adapt to environmental structure and optimally allocate its resources.This project investigates how the statistical structure of the environment influences the allocation of resources in human visual working memory (VWM). The aim is to determine the conditions under which VWM adaptively adjusts its resource distribution in response to environmental demands and to identify the behavioural indicators of such adaptation. Specifically, we will examine the temporal dynamics of adaptation and the characteristics of the environment that VWM can encode and take into account when distributing resources. Additionally, by applying computational models of population coding, we will explore biologically plausible neural mechanisms that enable adaptation and adaptive resource allocation.The findings of this research will have significant scientific and applied value, with potential benefits for the educational community and healthcare professionals working with vulnerable populations and developing cognitive rehabilitation programs.]]></summary_en></project><project>
<id>18046</id><title_hr><![CDATA[Prapovijesno odijevanje u Hrvatskoj: nošnja željeznoga doba u lokalnom i globalnom kontekstu]]></title_hr><title_en><![CDATA[Prehistoric Clothing in Croatia: Iron Age Dress in a Local and Global Context]]></title_en><user_id>3432</user_id><user_firstLast_name>Hrvoje Potrebica</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-1124</code><acronim><![CDATA[PreClothIA]]></acronim><duration>31.01.2026 - 30.01.2029</duration><status>U tijeku</status><financ_value>196.544,50 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Arheologija, Interdisciplinarne humanističke znanosti, </scie_field_hr><scie_field_en>Archeology, Interdisciplinary humanities, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>25275, 248, 870664, 27071, 27060, 7071, 17701, </team_members_id><team_members_names><![CDATA[Julia Katarina Fileš Kramberger, Katarina Nina Simončič, Karolina Pallin, Karina Grömer, Margarita Gleba, Marko Dizdar, Ana Sutlović, ]]></team_members_names><keywords_hr><![CDATA[odijevanje, nošnja, prapovijest, željezno doba, tekstil, rekonstrukcija, identitet, tekstilna arheologija, povijest odijevanja]]></keywords_hr><keywords_en><![CDATA[clothing, dress, prehistory, Iron Age, textile, reconstruction, identity, textile archaeology, history of clothing]]></keywords_en><summary_hr><![CDATA[Tekstil je složen društveni i gospodarski fenomen, a odjeća, osim što štiti tijelo od vremenskih uvjeta, ima ključnu ulogu u vizualnoj komunikaciji identiteta. Kroz odjevne izbore, kako tekstilnih, tako i ostalih elemenata nošnje, ljudi izražavaju pripadnost određenoj klasi, religijskoj skupini, ekonomskom sloju, obitelji ili zajednici. U željeznom dobu na prostoru Hrvatske dinamičnost i raznolikost elemenata nošnje posljedica su različitih čimbenika kao što je društveno nasljeđe, krajolik te komunikacija s okolnim zajednicama. Za proučavanje ovog problema upravo je prostor današnje Hrvatske iznimno povoljan jer su ovdje u željeznom dobu u interakciju stupili utjecaji četiriju velikih kulturnih zona: Sredozemlja, Balkana, Karpatske kotline i središnje Europe.Temeljni cilj ovoga projekta je uočiti oblike i odnose elemenata nošnje koji se u arheološkom materijalu pojavljuju kroz trajanje željeznog doba u različitim kulturnim zajednicama na području Hrvatske. Uz to, na temelju istog materijala te komparativnog materijala iz spomenutih okolnih zona, cilj je otkriti puteve komunikacija kroz prostor današnje Hrvatske te na koji način su ti impulsi na ovo područje, ali i iz njega, utjecali na oblikovanje materijalne kulture ovih zajednica. Pritom će se metodama tekstilne i eksperimentalne arheologije, digitalne rekonstrukcije te dizajna i modne rekonstrukcije ući u srž problematike predstavljanja identiteta kroz vizualne sastavnice odijevanja.]]></summary_hr><summary_en><![CDATA[Textiles are a complex social and economic phenomenon, and clothing, besides protecting the body from weather conditions, plays a key role in the visual communication of identity. Through choices in dress, including both textiles and other elements of attire, people express their belonging to a particular class, religious group, economic stratum, family, or community. In the Iron Age of present-day Croatia, the dynamics and diversity of dress elements resulted from various factors such as social heritage, landscape, and interactions with neighboring communities. This region is particularly well-suited for studying this issue, as four major cultural zones— the Mediterranean, the Balkans, the Carpathian Basin, and Central Europe—interacted here during the Iron Age.The main objective of this project is to identify the forms and relationships of dress elements that appear in the archaeological record throughout the Iron Age in different cultural communities within Croatia. Additionally, based on this material and comparative finds from the surrounding zones, the goal is to trace communication routes across present-day Croatia and understand how these influences shaped the material culture of these communities. By employing methods of textile and experimental archaeology, digital reconstruction, as well as fashion design and reconstruction, the aim of the project is to explore the core issues of identity representation through the visual components of clothing.]]></summary_en></project><project>
<id>18048</id><title_hr><![CDATA[Karakterizacija i dinamika viroma uspješnih invazivnih stranih vrsta slatkovodnih rakova]]></title_hr><title_en><![CDATA[Virome characterization and dynamics in successful crayfish invaders]]></title_en><user_id>19913</user_id><user_firstLast_name>Sandra Hudina</user_firstLast_name><svouser_id>867825</svouser_id><svouser_firstLast_name>Antonin Kouba</svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-5489</code><acronim><![CDATA[ViroCray]]></acronim><duration>31.12.2025 - 30.12.2028</duration><status>U tijeku</status><financ_value>197.900,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>12634, 19415, 867894, 22737, 865222, 867967, </team_members_id><team_members_names><![CDATA[Ivana Maguire, Romana Gračan, Matej Vucić, Silvija Černi, Ljudevit Luka Boštjančić, Donald Behringer, ]]></team_members_names><keywords_hr><![CDATA[invazivne vrste, invazivni uspjeh, virusi, invazija posredovana mikrobima, HTS ]]></keywords_hr><keywords_en><![CDATA[invasive species, invasion success, viruses, microbially mediated invasions, HTS ]]></keywords_en><summary_hr><![CDATA[Invazivne strane vrste (ISV) predstavljaju prijetnju bioraznolikosti, dobrobiti ljudi i globalnom gospodarstvu te pridonose degradaciji usluga ekosustava. Razumijevanje čimbenika koji omogućuju invazivni uspjeh ISV ključno je za ublažavanje njihovog utjecaja. Rezultati nedavnih istraživanja ukazali su na značajnu ulogu mikrobnih zajednica domaćina u biološkim invazijama. Posebno se ističe virom (mikrobiom povezan s virusima) ISV-a koji je uglavnom neistražen, iako su virusi najbrojniji patogeni u okolišu i mogu značajno utjecati na invazivni uspjeh ISV. U ovom projektu analizirat ćemo virom jedne od najuspješnijih skupina slatkovodnih ISV-a, deseteronožnih rakova. Prvo ćemo napraviti opsežnu karakterizaciju viroma tri uspješne vrste invazivnih rakova u EU: signalnog, bodljobradog i mramornog raka. Koristeći najsuvremenije metagenomske pristupe, identificirat ćemo poznate i nove viruse prisutne u račjim organima i u najmanje 10 populacija odabranih invazivnih rakova i analizirati njihovu distribuciju i povezanost s rakovima naprednim pretraživanjem baza podataka za otkrivanje virusnih sekvenci. Drugo, usporedit ćemo virome različitih vrsta rakova i u različitim ekološkim kontekstima (između autohtonog i invazivnog areala, između populacija različite starosti, prisutnosti srodnih vrsta itd.) kako bismo razjasnili utjecaj ekološkog konteksta na sastav i raznolikost viroma. Konačno, provest ćemo opsežni kohabitacijski eksperiment kako bismo istražili potencijalnu homogenizaciju viroma tijekom kontakta između vrsta i njezine mehanizme. Također ćemo istražiti povezanost zdravstvenog statusa rakova (procjenom imunosnog odgovora i statusa organa) s opaženim promjenama viroma. Ovaj multidisciplinarni okvir temeljen na invazivnoj ekologiji, virologiji i imunologiji, koji uključuje terenska i eksperimentalna istraživanja kao i korištenje sekvenciranja visoke propusnosti, omogućit će nam procjenu dinamike viroma tijekom invazije i njegove uloge u invazivnom uspjehu vrsta.]]></summary_hr><summary_en><![CDATA[Invasive non-native species (INNS) threaten biodiversity, human well-being and global economy, and impair ecosystem services worldwide. Understanding the factors that facilitate INNS invasion success is essential for mitigating their impacts. Recent studies have highlighted the significant role of host-associated microbial communities in biological invasions. In particular, INNS virome (virus-associated microbiome) is largely unexplored, despite viruses being the most numerous pathogens in the environment that may significantly impact invasion success. ViroCray will analyse virome dynamics in successful aquatic invaders, the freshwater crayfish. Firstly, we will perform an extensive virome characterisation in three successful and widespread crayfish invaders in the EU: the signal crayfish, the spiny-cheek crayfish and the marbled crayfish. Using cutting-edge metagenomic approaches, we will identify known and novel viruses across different organs and in at least 10 populations of selected invaders and analyse their distribution and crayfish association by datamining research using databases for the discovery of viral sequences. Secondly, we will compare crayfish viromes between species and across different ecological contexts (native vs. invasive range, different introduction histories, presence of congeners etc.) to elucidate the context-dependent effects on virome composition and diversity. Finally, we will perform an extensive experimental study to examine the potential virome homogenisation during species contacts and its underlying mechanisms. We will also examine the effects of crayfish health status (assessed through immune response, organ status analyses) on observed virome changes. This comprehensive framework on the intersection between invasion ecology, virology and immunology which combines field and experimental research with metagenomic approaches will allow us to assess virome dynamics during invasion and its role in invasion success of species.]]></summary_en></project><project>
<id>18048</id><title_hr><![CDATA[Karakterizacija i dinamika viroma uspješnih invazivnih stranih vrsta slatkovodnih rakova]]></title_hr><title_en><![CDATA[Virome characterization and dynamics in successful crayfish invaders]]></title_en><user_id>19913</user_id><user_firstLast_name>Sandra Hudina</user_firstLast_name><svouser_id>867838</svouser_id><svouser_firstLast_name>Denis Kutnjak</svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-5489</code><acronim><![CDATA[ViroCray]]></acronim><duration>31.12.2025 - 30.12.2028</duration><status>U tijeku</status><financ_value>197.900,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>12634, 19415, 867894, 22737, 865222, 867967, </team_members_id><team_members_names><![CDATA[Ivana Maguire, Romana Gračan, Matej Vucić, Silvija Černi, Ljudevit Luka Boštjančić, Donald Behringer, ]]></team_members_names><keywords_hr><![CDATA[invazivne vrste, invazivni uspjeh, virusi, invazija posredovana mikrobima, HTS ]]></keywords_hr><keywords_en><![CDATA[invasive species, invasion success, viruses, microbially mediated invasions, HTS ]]></keywords_en><summary_hr><![CDATA[Invazivne strane vrste (ISV) predstavljaju prijetnju bioraznolikosti, dobrobiti ljudi i globalnom gospodarstvu te pridonose degradaciji usluga ekosustava. Razumijevanje čimbenika koji omogućuju invazivni uspjeh ISV ključno je za ublažavanje njihovog utjecaja. Rezultati nedavnih istraživanja ukazali su na značajnu ulogu mikrobnih zajednica domaćina u biološkim invazijama. Posebno se ističe virom (mikrobiom povezan s virusima) ISV-a koji je uglavnom neistražen, iako su virusi najbrojniji patogeni u okolišu i mogu značajno utjecati na invazivni uspjeh ISV. U ovom projektu analizirat ćemo virom jedne od najuspješnijih skupina slatkovodnih ISV-a, deseteronožnih rakova. Prvo ćemo napraviti opsežnu karakterizaciju viroma tri uspješne vrste invazivnih rakova u EU: signalnog, bodljobradog i mramornog raka. Koristeći najsuvremenije metagenomske pristupe, identificirat ćemo poznate i nove viruse prisutne u račjim organima i u najmanje 10 populacija odabranih invazivnih rakova i analizirati njihovu distribuciju i povezanost s rakovima naprednim pretraživanjem baza podataka za otkrivanje virusnih sekvenci. Drugo, usporedit ćemo virome različitih vrsta rakova i u različitim ekološkim kontekstima (između autohtonog i invazivnog areala, između populacija različite starosti, prisutnosti srodnih vrsta itd.) kako bismo razjasnili utjecaj ekološkog konteksta na sastav i raznolikost viroma. Konačno, provest ćemo opsežni kohabitacijski eksperiment kako bismo istražili potencijalnu homogenizaciju viroma tijekom kontakta između vrsta i njezine mehanizme. Također ćemo istražiti povezanost zdravstvenog statusa rakova (procjenom imunosnog odgovora i statusa organa) s opaženim promjenama viroma. Ovaj multidisciplinarni okvir temeljen na invazivnoj ekologiji, virologiji i imunologiji, koji uključuje terenska i eksperimentalna istraživanja kao i korištenje sekvenciranja visoke propusnosti, omogućit će nam procjenu dinamike viroma tijekom invazije i njegove uloge u invazivnom uspjehu vrsta.]]></summary_hr><summary_en><![CDATA[Invasive non-native species (INNS) threaten biodiversity, human well-being and global economy, and impair ecosystem services worldwide. Understanding the factors that facilitate INNS invasion success is essential for mitigating their impacts. Recent studies have highlighted the significant role of host-associated microbial communities in biological invasions. In particular, INNS virome (virus-associated microbiome) is largely unexplored, despite viruses being the most numerous pathogens in the environment that may significantly impact invasion success. ViroCray will analyse virome dynamics in successful aquatic invaders, the freshwater crayfish. Firstly, we will perform an extensive virome characterisation in three successful and widespread crayfish invaders in the EU: the signal crayfish, the spiny-cheek crayfish and the marbled crayfish. Using cutting-edge metagenomic approaches, we will identify known and novel viruses across different organs and in at least 10 populations of selected invaders and analyse their distribution and crayfish association by datamining research using databases for the discovery of viral sequences. Secondly, we will compare crayfish viromes between species and across different ecological contexts (native vs. invasive range, different introduction histories, presence of congeners etc.) to elucidate the context-dependent effects on virome composition and diversity. Finally, we will perform an extensive experimental study to examine the potential virome homogenisation during species contacts and its underlying mechanisms. We will also examine the effects of crayfish health status (assessed through immune response, organ status analyses) on observed virome changes. This comprehensive framework on the intersection between invasion ecology, virology and immunology which combines field and experimental research with metagenomic approaches will allow us to assess virome dynamics during invasion and its role in invasion success of species.]]></summary_en></project><project>
<id>18052</id><title_hr><![CDATA[Terra nullius - na granici i iza granice od 8. do 12. st.]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6829</user_id><user_firstLast_name>Krešimir Filipec</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-8995</code><acronim><![CDATA[TerraNullbord]]></acronim><duration>02.03.2026 - 01.03.2032</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Arheologija, </scie_field_hr><scie_field_en>Archeology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>873195</team_members_id><team_members_names><![CDATA[ Doktorand: Lovro Vragolović ]]></team_members_names><keywords_hr><![CDATA[Slaveni, Avari, Karolinzi, granice, granična područja, Donja Panonija, Siscia, Lobor, Poetovio]]></keywords_hr><keywords_en><![CDATA[Slavs, Avars, Carolingians, borders, border areas, Lower Pannonia, Siscia, Lobor, Poetovio]]></keywords_en><summary_hr><![CDATA[Projekt Terra nullius – na granici i iza granice od 8. do 12. stoljeća obuhvaća teritorij omeđen Podravinom na sjeveru i Posavinom na jugu, a predstavlja kronološki nastavak i proširivanje dosadašnjih projekata predlagatelja prof. dr. sc. Krešimira Filipca. Navedeni je prostor, u povijesnoj literaturi, opisivan kao Panonska Hrvatska, u ranom srednjem vijeku često se pripisivao različitim gospodarima, a ponekad se opisuje i kao ničija zemlja, odnosno terra nullius. Terra nullius je pravni izraz koji se odnosi na „teritorij bez gospodara“. Čini se da se na toj „ničijoj zemlji“, početkom 10. stoljeća geopolitička tvorevina bliska državi. Život na granici i iza granice na toj „ničijoj“ zemlji (terra nullius) od 8. do 12. st. između jakih, velikih i snažnih sila tema je koja u arheološkoj literaturi nije često obrađivana te mnogi problemi ne samo da nisu riješeni već nisu niti otvoreni. U pomanjkanju drugih dostupnih izvora, groblja su nam često jedini pokazatelj veza i odnosa u ranom srednjem vijeku. Tu se može pratiti protok predmeta koji često upućuje na različite veze i suodnose, a položaj groblja u prostoru, npr. u odnosu na crkvu svjedoči o tome je li riječ o organiziranom području s gospodarom koji prati tadašnje procese ili ne. Smještaj groblja uz crkvu općenito se povezuje uz vrijeme kada postoji jača politička organizacija koja može ljude primorati da svoja stara groblja premjeste tamo gdje im je zadano. Cilj projekta razotkriti je neistražena pitanja navedenog područja, kako bi istraživanje upotpunilo znanstveno istraživanje prostora hrvatskog dijela Panonije u ranom srednjem vijeku.]]></summary_hr><summary_en><![CDATA[The project Terra nullius - on the border and beyond the border from the 8th to the 12th century covers the territory between Podravina in the north and Posavina in the south, and represents a chronological continuation and expansion of the previous projects by the applicant Prof. Krešimir Filipec. In the historical literature, the mentioned area was described as Pannonian Croatia, in the early Middle Ages it was often attributed to different lords, and sometimes it was described as no man&#39;s land, i.e. terra nullius. Terra nullius is a legal term referring to a „territory without a master“. It seems that in this „no man&#39;s land“, at the beginning of the 10th century, a geopolitical creation close to a state was formed. Life on the border and behind the border in that „no man&#39;s land“ (terra nullius) from the 8th to the 12th century between strong, great and powerful forces is a topic that is not often discussed in the archaeological literature, and many problems not only have not been solved but have not been even opened. In the absence of other available sources, cemeteries are often our only indication of connections and relationships in the early Middle Ages. There the flow of objects can be followed, which often points to different connections and correlations, and the position of the cemetery in landscape, for example in relation to the church, testifies to whether or not it was an organized area with a lord who followed the processes of the time. Placing a cemetery next to a church is generally associated with a time when there is a strong political organization that can force people to move their old cemeteries to their designated locations. The aim of the project is to expose the unexplored questions of the mentioned area, in order to complete the scientific research of the Croatian part of Pannonia in the early Middle Ages.]]></summary_en></project><project>
<id>18054</id><title_hr><![CDATA[Eksperimentalno proučavanje nukleonskih korelacija nuklearnim reakcijama]]></title_hr><title_en><![CDATA[Nuclear reactions for experimental studies of nucleon correlations]]></title_en><user_id>166</user_id><user_firstLast_name>Suzana Szilner</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-2414</code><acronim><![CDATA[NuRESCo]]></acronim><duration>15.01.2026 - 14.01.2029</duration><status>U tijeku</status><financ_value>182.850,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>414, 163, 865037, 866605, 866600, 4019, </team_members_id><team_members_names><![CDATA[Neven Soić, Igor Gašparić, Luka Palada, Ivana Lihtar, Margareta Sigmund, Matko Milin, ]]></team_members_names><keywords_hr><![CDATA[nuklearna struktura, nuklearne reakcije, nukleonske korelacije, nuklearni klasteri, nuklearne molekule]]></keywords_hr><keywords_en><![CDATA[nuclear structure, nuclear reactions, nucleon-nucleon correlations, nuclear clustering, nuclear molecular states]]></keywords_en><summary_hr><![CDATA[Cilj predloženog projekta je produbiti naše razumijevanje nuklearne fizike provođenjem ciljanih eksperimenata uz korištenje naprednih detektorskih sustava i namjenskih akceleratorskih postrojenja. Koristit ćemo već stečeno znanje i iskustvo iz naših prethodnih projekata kako bismo unaprijedili eksperimentalne metode i tehnike za dobivanje novih, kvalitetnih podataka u istraživanju specifičnih fenomena u eksperimentalnoj nuklearnoj fizici. Posebno ćemo se usredotočiti na proučavanje nukleonskih korelacija upotrebom egzotičnih snopova, na proučavanje multineutronskih sustava direktnom detekcijom neutrona, na potragu za gama zračenjem povezanim s oscilacijama koje stvara proces prijenosa dva neutrona. Dodatno, prikupit ćemo nove eksperimentalne podatke o neobičnim, vrlo deformiranim stanjima u lakim jezgrama, nuklearnim molekulama, prepoznatim u jezgri 10Be kao strukture u kojoj dva alfa-klastera dijele dva dodatna neutrona. Također ćemo tražiti jasne eksperimentalne dokaze o postojanju klasterskih struktura s tri centra, sličnim 3-alfa stanju u 12C, predviđenim i u drugim lakim jezgrama. Većina predloženog eksperimentalnog rada odvijat će se u vrhunskim međunarodnim akceleratorskim centrima koristeći najsuvremenije detektorske sustave. U odgovarajućim slučajevima, mjerenja će se izvoditi u (novom) akceleratorskom kompleksu IRB-a, gdje će ugradnja nove komore za nuklearne reakcije poboljšati istraživačke mogućnosti. Znanstvenici uključeni u ovaj projekt bili su glasnogovornici brojnih eksperimenata u međunarodnim centrima, što je rezultiralo visokokvalitetnim publikacijama, te uživaju značajan međunarodni ugled. Ovaj projekt konsolidira hrvatsku zajednicu eksperimentalnih nuklearnih fizičara niskih i srednjih energija i ojačat će hrvatsku prisutnost u europskim istraživanjima nuklearne fizike.]]></summary_hr><summary_en><![CDATA[The proposed project aims at expanding present understanding of nuclear physics by conducting targeted experiments using advanced detection systems and dedicated accelerator facilities. We will use the already acquired knowledge and experience from our previous projects to further improve existing experimental methods and techniques with the aim to collect new high-quality data which are necessary to address specific key open questions in experimental nuclear physics. In particular, we will focus on studies of nucleon-nucleon correlations by using exotic beams, studies of correlations in multi-neutron systems through direct neutron detection, and the search for gamma radiation associated with the oscillations generated by the two-neutron transfer process. Additionally, we will provide new experimental results on isospin analog nuclear molecular states connected with the known structure in 10Be, the highly-deformed configuration of two alpha-clusters sharing two additional neutrons. We will also search for the experimental evidence of cluster structures with three centers, the analogue of the 3-alpha state in 12C, proposed to exist in other light nuclei. Most of the proposed experimental work will be performed at the top international accelerator facilities using state-of-the-art detection systems. In well suited cases, measurements will be performed at the (new) RBI accelerator complex, where the installation of a new scattering chamber will enhance the research capabilities of the RBI facility. The scientists involved in this project have been spokespersons of numerous experiments at international facilities, that resulted in high-quality publications, with considerable international reputation. This project will further strengthen the Croatian community of experimental low- and medium-energy nuclear physics and it will enhance Croatia&#39;s presence in the European frame.]]></summary_en></project><project>
<id>18056</id><title_hr><![CDATA[Višerječni izrazi u hrvatskome jeziku – leksikološki, računalnolingvistički i glotodidaktički pristup ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>19128</user_id><user_firstLast_name>Goranka Blagus Bartolec</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-7629</code><acronim><![CDATA[MWE-Cro]]></acronim><duration>29.11.2025 - 28.11.2030</duration><status>U tijeku</status><financ_value>60,00 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filologija, </scie_field_hr><scie_field_en>Philology, </scie_field_en><institution_hr><![CDATA[Institut za hrvatski jezik]]></institution_hr><institution_en><![CDATA[Institute of Croatian Language]]></institution_en><team_members_id>872963</team_members_id><team_members_names><![CDATA[ Doktorand: Martina Pliestić ]]></team_members_names><keywords_hr><![CDATA[mrežna baza, višerječni izrazi, leksikologija, glotodidaktika, hrvatski jezik]]></keywords_hr><keywords_en><![CDATA[online database, multiword expressions, lexicology, glottodidactics, Croatian]]></keywords_en><summary_hr><![CDATA[Glavni je cilj projekta razviti mrežno pretraživ i javno dostupan repozitorij višerječnih izraza hrvatskoga jezika s opisom njihovih gramatičkih i značenjskih obilježja. Obrađeni podatci bit će koristan izvor za: 1. različita jezikoslovna istraživanja, 2. unaprjeđenje korpusnih alata za prepoznavanje višerječnih izraza (općih i stručnih kolokacija, frazema, poslovica, pragmema, gramatičkih sveza), 3. istraživanja na kontrastivnoj razini za potrebe prevođenja, izrade paralelnih korpusa te u poučavanju i učenju hrvatskoga kao inoga jezika. Kategorizacija višerječnih izraza temeljit će se na postojećim teorijskim opisima višerječnih izraza, osobito onim kojima su određene suvremene smjernice proučavanja takvih sveza u 21. stoljeću, što uključuje primjenu i unapređenje korpusnih i računalnih tehnologija, primjenu višerječnih izraza u govoru te njihovu percepciju pri usvajanju hrvatskoga kao inoga jezika. U okviru projekta razvit  će se 5 baza – opća baza višerječnih izraza, baza frazema, baza hrvatskih poslovica, baza višerječnih izraza u okviru hrvatskoga kao inoga jezika, baza glagolskih kolokacija hrvatskoga, poljskoga, njemačkoga i engleskoga jezika. Poslovice kao plodna skupina višerječnih izraza temeljenih na izricanju narodnih mudrosti, za razliku od frazema, znatno su manje zastupljene u suvremenim leksikografskim izvorima, korpusima i nastavi Hrvatskoga jezika, što nameće potrebu njihova uvrštavanja u mrežnu bazu kako bi bile dostupne i sadašnjim i budućim, izvornim i stranim, govornicima hrvatskoga jezika. Glagolske kolokacije u hrvatskom i drugim jezicima važna su i složena skupina višerječnih izraza, a izrada baze glagolskih kolokacija kao i drugih višerječnih sveza olakšala bi i unaprijedila poučavanje hrvatskoga kao inoga jezika. Baze višerječnih izraza danas su jedan od temeljnih jezičnih resursa svakoga jezika te ključna karika u razvoju obrade prirodnoga jezika. Držimo stoga da je izrada takva mrežnog resursa strateški važna za hrvatski jezik.  ]]></summary_hr><summary_en><![CDATA[The main objective of the project is to develop an online searchable and publicly available repository of multiword expressions (MWEs) in Croatian with a description of their grammatical and semantic features. Processed data will be a useful source for: 1 various linguistic researches, 2 improvement of corpus tools for detecting MWEs (collocations, idioms, proverbs, grammatical phrases), 3 the contrastive research applicable in translation, creating parallel corpora, and learning Croatian as a foreign language. The classification of MWEs will be based on the existing theoretical descriptions, especially those that have determined the modern guidelines for the study of such phrases in the 21st century, which includes the improvement of corpus and computer technologies, the use of MWEs in a spoken context and adopting Croatian as foreign language. The project proposal includes the development of 5 databases – a basic database of MWEs, an idiom database, a proverb database, a database of MWEs in Croatian as foreign language, a database of verb collocations in Croatian, Polish, German, and English. Proverbs, based on the folk wisdom, unlike idioms, are less represented MWEs in contemporary lexicography, corpora and teaching of Croatian, which imposes the need to include them in an online database so that they are available to native and non-native speakers of Croatian. Verb collocations in Croatian and other languages are an important and complex group of MWEs that require special attention when learning the language. Development of the Verb collocations database, as well as other multiword expressions, would facilitate and thus improve the teaching of Croatian as a second and foreign language. Today, databases of MWEs are one of the fundamental linguistic resources of every language and a key link in the improvement of natural language processing. We therefore believe that the development of such a resource is strategically important for Croatian.]]></summary_en></project><project>
<id>18057</id><title_hr><![CDATA[Istraživanje eocenskih klimatskih promjena Istarskog bazena Neotetisa]]></title_hr><title_en><![CDATA[Tracking Eocene climate change in the Istrian basin (Croatia) of the Neotethys]]></title_en><user_id>4277</user_id><user_firstLast_name>Ines Galović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-9929</code><acronim><![CDATA[TEaCh-IN]]></acronim><duration>12.11.2025 - 11.12.2028</duration><status>U tijeku</status><financ_value>188.380,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Geologija, Kemija, Biologija, Interdisciplinarne prirodne znanosti, </scie_field_hr><scie_field_en>Geology, Chemistry, Biology, Interdisciplinary natural sciences, </scie_field_en><institution_hr><![CDATA[Hrvatski geološki institut]]></institution_hr><institution_en><![CDATA[Croatian Geological Survey]]></institution_en><team_members_id>19182, 5741, 1058, 4014, 5740, 870705, 22722, </team_members_id><team_members_names><![CDATA[Stanislav Bergant, Morana Hernitz Kučenjak, Nenad Tomašić, Marija Horvat, Vlasta Premec Fućek, Przemyslaw Gedl, Mario Matošević, ]]></team_members_names><keywords_hr><![CDATA[mikrofosili, biodiverzitet, klimatske promjene, eocen, Mediteran ]]></keywords_hr><keywords_en><![CDATA[microfossils, biodiversity, climate warming, Eocene, Mediterranean]]></keywords_en><summary_hr><![CDATA[Istraživanje klimatskih promjena eocenskih naslaga i njihovo praćenje uz pomoć izotopa kisika i ugljika kao i uz pomoć geokemijskih parametara do prijašnjeg projekta BREEMECO uopće kao takva nisu bila zastupljena u Hrvatskoj. Navedeni izotopi su moćan alat za utvrđivanje poznatog srednjoeocenskog temperaturnog maksimuma (kasno-lutetski maximum) i optimuma (srednjoeocenski klimatski optimum). Uz pomoć započetog multidisciplinarnog pristupa u okviru prijašnjeg projekta sa geokemijskim parametrima i mikrofosilima (foraminifere) te uključivanjem palinomorfa uz dosadašnje kokolitoforide, poboljšat će se preliminarni rezultati rađeni na manjim profilima u Istri (do 10 m). Sada će se na profilima od više 10-taka m u Istri istraživanje proširiti i na odabrane Jadranske bušotine za koje se zna da su foraminifere puno bolje sačuvane nego na dosadašnjim profilima. Time će se omogućiti bolje praćenje paleoklimatskih promjena uz pomoć izotopa, koje će se onda moći usporediti sa regionalnim i globalnim podacima.  Po prvi put će se uvesti TEX86 metoda za dobivanje temperature mora što će pridonjeti boljem razumijevanju fundamentalnog pitanja prilagodbe današnjih organizama izloženih temperaturnim promjenama. Istražit će se kako klimatske promjene utječu na navedene mikrofosile i okoliše, što će dati bolji uvid u mogući scenarij današnjih, a i budućih njihovih prilagodbi. Biostratigrafske zonacije i paleoekološki parametri dominantnih vrsta u navedenim mikrofosilnim zajednicama, zajedno sa palinomorfama, poboljšat će dosadašnji paleoekološki aspekt i dati paleoklimatski model za vrijeme eocena. Ishodi istraživanja projekta pridonjet će boljem cjelokupnom razumijevanju klime koja je bila zastupljena na području Istre, a koja dosad kao takva nije bila u fokusu istraživanja u Hrvatskoj. Ova istraživanja su izuzetno važna za bolje razumijevanje klimatskih promjena i njihovih utjecaja, što bi trebalo pridonijeti budućim studijama održivosti i prilagodbe na klimatske promjene.]]></summary_hr><summary_en><![CDATA[Prior to the BREEMECO project only biostratigraphic studies and reconstruction of the sedimentary environment had been conducted. Oxygen and carbon isotopes are a powerful tool for identifying middle Eocene warm events (Late Lutetian Thermal Maximum and Middle Eocene Climatic Optimum). With the help of the multidisciplinary approach initiated within the previous project, which included some geochemical parameters and now with palynomorph assemblages, we propose to improve the preliminary results made on smaller outcrops in Istria. Here we will extend the research to outcrops of more than 10 m, and to selected Adriatic wells, where foraminifera are much better preserved than in the previous outcrops. Analysis of foraminiferal stable isotopes will enable better evaluation of local paleoclimate changes, which will then be able to be better compared with regional and global data. This project will also include the use of the TEX86 sea surface temperature method in this region for the first time, which will contribute to a better understanding of adaptation of organisms to temperature changes in marine environment, which is a fundamental issue today. We will investigate how climate change affected these microorganisms and their environments, which could give insight into current and future their adaptations. Analysis of microfossil assemblages for biostratigraphy and paleoecological parameters based on the dominant species, together with palynomorphs, will improve the current paleoecological understanding and provide critical parameters for paleoclimatic models of the Eocene. The research outcomes will contribute to a better overall understanding of Eocene climate in Istria and beyond, which has not been the focus of research in Croatia so far. This is extremely important for a better understanding of climate change and its impacts, and will contribute to future studies on sustainability and adaptation of organisms, including humans, to coming climate changes.]]></summary_en></project><project>
<id>18060</id><title_hr><![CDATA[Energijski status zajednice makrobeskralježnjaka kao pokazatelj zdravlja urbanih potoka]]></title_hr><title_en><![CDATA[Energy Status of the Macroinvertebrate Community as a Proxy for Urban Stream Health]]></title_en><user_id>724</user_id><user_firstLast_name>Marijana Erk</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-4563</code><acronim><![CDATA[ESCAPE-US]]></acronim><duration>05.12.2025 - 04.12.2028</duration><status>U tijeku</status><financ_value>199.887,50 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Interdisciplinarne prirodne znanosti, Kemija, Biologija, </scie_field_hr><scie_field_en>Interdisciplinary natural sciences, Chemistry, Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>12351, 12871, 869995, 181, 197, 870029, 870100, 865016, </team_members_id><team_members_names><![CDATA[Mirela Sertić Perić, Sanja Gottstein, Amela Hozić, Maja Đokić, Marija Sedak, Damir Pavliček, Marija Denžić Lugomer, Elena Petrović, ]]></team_members_names><keywords_hr><![CDATA[kemijska zagađivala, energijski metabolizam, oksidacijski stres, zajednica beskralježnjaka, slatkovodni ekosustavi]]></keywords_hr><keywords_en><![CDATA[chemical contaminants, energy metabolism, oxidative stress, macroinvertebrate community, freshwater ecosystems]]></keywords_en><summary_hr><![CDATA[Primarni cilj ovog projekta je razviti metodologije za prikupljanje podataka ključnih za uspostavu univerzalnog, integriranog pokazatelja za procjenu zdravlja urbanih potoka, temeljenog na promjenama ravnoteže metaboličke energije biote. Ovaj bi pokazatelj pomogao u otkrivanju antropogenih utjecaja na ekosustave urbanih potoka. Projekt će analizirati kemijska onečišćenja prisutna u vodi, strukturu zajednice (bioraznolikost i brojnost) makrobeskralježnjaka, uz kvantificiranje fizioloških parametara koji odražavaju energijski status i antioksidativni kapacitet tih organizama. Usredotočujući se na svojte s različitih trofičkih razina i ekoloških funkcija, projekt ima za cilj prikupiti podatke koji će pomoći u određivanju ukupnog zdravlja urbanih potoka te procjeni antropogenih utjecaja na različitim postajama uzorkovanja i njihove sezonske varijabilnosti. Kombinacija kemijskog, biološkog i ekofiziološkog pristupa omogućit će sveobuhvatno razumijevanje načina na koji ekosustavi urbanih potoka reagiraju na ljudske utjecaje. Diseminacijske projektne aktivnosti uključit će predstavljanje rezultata na konferencijama, objavljivanje znanstvenih članaka i organiziranje trodnevne radionice namijenjene studentima doktorskih studija biologije, znanosti o okolišu, ekologije i srodnih disciplina. Radionica će predstaviti istraživačke metodologije razvijene tijekom projekta, uključujući praktičnu obuku, rasprave o novim analitičkim tehnikama i zajedničko osmišljavanje indeksa zdravlja urbanih potoka na temelju dostupnih podataka. Ove aktivnosti diseminacije također će pružiti platformu za povratne informacije, usmjeravajući budući smjer istraživanja i potičući interdisciplinarnu suradnju. Na kraju, rezultati ovog projekta pružit će nove uvide koji mogu doprinijeti poboljšanju upravljanja i zaštite urbanih potoka i njihovih usluga ekosustava.]]></summary_hr><summary_en><![CDATA[The primary goal of this project is to develop methodologies for the collection of data crucial for establishment of a universal, integrated indicator for the assessment of the health of urban streams based on changes in the metabolic energy balance of the resident biota. This indicator would help to reveal the anthropogenic impacts on urban stream ecosystems. The project will analyse chemical contaminants in the water, community structure (biodiversity and the abundance) of macroinvertebrates, alongside quantifying physiological parameters that reflect the energy status and antioxidant capacity of these organisms. By focusing on taxa from different trophic levels and ecological functions, the project aims to collect data that will help determine the overall health of urban streams, assess anthropogenic impacts at different sites and evaluate their seasonal variability. Combining chemical, biological, and ecophysiological approaches will provide a comprehensive understanding of how urban stream ecosystems respond to human influences. Dissemination activities for the project will include presenting the results at conferences, publishing scientific articles, and organizing a 3-day workshop aimed at PhD students in biology, environmental science, ecology, and related disciplines. The workshop will demonstrate the research methodologies developed within the project, including hands-on training, discussions on new analytical techniques, and collaborative brainstorming on creating an Urban Stream Health Index based on the available data. These dissemination activities will also provide a platform for feedback, guiding the future direction of research and encouraging interdisciplinary collaboration. As a final point, the results of this project will provide new insights that can contribute to improving the management and protection of urban streams and their ecosystem services.]]></summary_en></project><project>
<id>18062</id><title_hr><![CDATA[Razvoj visokoučinkovitog metal-hidridnog kompresora s integriranom jedinicom za pohranu topline za napredne vodikove punionice]]></title_hr><title_en><![CDATA[Design and Fabrication of a Metal hydride hydrogen compressor incorporating a heat storage unit for hydrogen refueling stations]]></title_en><user_id>3668</user_id><user_firstLast_name>Ivan Tolj</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-1981</code><acronim><![CDATA[HyRefuelStat]]></acronim><duration>31.12.2025 - 30.12.2028</duration><status>U tijeku</status><financ_value>200.000,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, </scie_field_hr><scie_field_en>Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Fakultet elektrotehnike, strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Electrical Engineering, Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>3698, 865046, 908, 872928, </team_members_id><team_members_names><![CDATA[Gojmir Radica, Tino Vidović, Branko Klarin, Moegamat Wafeeq Davids, ]]></team_members_names><keywords_hr><![CDATA[Metal Hydride Compressor, Hydrogen Storage, Thermal Management, High-Pressure Compression, Hydrogen Refueling, Energy Efficiency]]></keywords_hr><keywords_en><![CDATA[Metal hidridni kompresor, Skladištenje vodika, Toplinsko upravljanje, Visokotlačna kompresija, Punjenje vodikom, Energetska učinkovitost]]></keywords_en><summary_hr><![CDATA[Projekt &#39;&#39;Razvoj visokoučinkovitog metal-hidridnog kompresora s integriranom jedinicom za pohranu topline za napredne vodikove punionice&#39;&#39; (HyRefuelStat) ima za cilj razviti inovativni kompresor vodika na bazi metalnog hidrida u dva stupnja (MHHC) integriran s pohranom topline (TES) kako bi se poboljšala učinkovitost i pouzdanost postaja za punjenje vodikom (HRS). Istraživanje se bavi izazovima pohrane i kompresije vodika, koji su ključni za vodikovu ekonomiju. Predloženi sustav koristi metalne hidride zbog njihove visoke volumetrijske gustoće vodika, sigurnosti i isplativosti, u kombinaciji s fazno promjenjivim materijalima (PCM) za pohranu topline kako bi se omogućio neprekidan rad HRS-a. Projekt se temelji na prethodnim istraživanjima u području reaktora metalnog hidrida i termalnog upravljanja, s fokusom na optimizaciju termofizikalnih svojstava metalnih hidrida tipa AB5 i AB2, poboljšanje prijenosa topline i razvoj strategije kompresije u više stupnjeva. Metodologija uključuje odabir materijala, dizajn sustava, matematičko modeliranje, izradu prototipa i evaluaciju performansi. Očekivani rezultati uključuju validirani prototip, sveobuhvatnu termodinamičku i ekonomsku analizu te smjernice za integraciju sustava u postojeću infrastrukturu HRS-a. Istraživanje je usklađeno s EU i hrvatskim strategijama za vodik, doprinosi razvoju održive vodikove ekonomije i ima za cilj poboljšanje učinkovitosti i sigurnosti sustava pohrane vodika, omogućujući praktičnu primjenu gorivih članaka u transportu i stacionarnim aplikacijama, te smanjenje ovisnosti o fosilnim gorivima. Projekt također ima značajne ekonomske i društvene utjecaje, potičući lokalnu proizvodnju, stvaranje radnih mjesta i smanjenje onečišćenja okoliša. Nalazi će biti disseminirani kroz časopise s visokim utjecajem i međunarodne konferencije, pozicionirajući Hrvatsku i EU kao lidera u inovacijama čiste energije.]]></summary_hr><summary_en><![CDATA[The project &#39;&#39;Development of a High-Efficiency Metal Hydride Compressor with an Integrated Thermal Storage Unit for Advanced Hydrogen Refueling Stations&#39;&#39; (HyRefuelStat) aims to develop an innovative 2-stage metal hydride hydrogen compressor (MHHC) integrated with thermal energy storage (TES) to enhance the efficiency and reliability of hydrogen refueling stations (HRS). The research addresses the challenges of hydrogen storage and compression, which are critical for the hydrogen-based economy. The proposed system leverages metal hydrides for their high volumetric and gravimetric hydrogen densities, safety, and cost-effectiveness, combined with phase change materials (PCM) for thermal energy storage to enable continuous operation of HRS. The project builds on previous research in metal hydride reactors and thermal management, focusing on optimizing the thermophysical properties of AB5- and AB2-type metal hydrides, improving heat transfer, and developing a multi-stage compression strategy. The methodology includes material selection, system design, mathematical modeling, prototype fabrication, and performance evaluation. The expected outcomes include a validated prototype, comprehensive thermodynamic and economic analysis, and guidelines for integrating the system into existing HRS infrastructure. The research aligns with EU and Croatian hydrogen strategies, contributing to the development of a sustainable hydrogen economy. It aims to enhance the efficiency and safety of hydrogen storage systems, enable practical deployment of fuel cells in transport and stationary applications, and reduce reliance on fossil fuels. The project also has significant economic and societal impacts, fostering local manufacturing, creating job opportunities, and reducing environmental pollution. The findings will be disseminated through high-impact journals and international conferences, positioning Croatia and the EU as leaders in clean energy innovation. ]]></summary_en></project><project>
<id>18067</id><title_hr><![CDATA[Poboljšanje sinaptičkog prijenosa derivatima piridina i nikotinamida]]></title_hr><title_en><![CDATA[Boosting Synaptic Transmission with Pyridine and Nicotinamide Derivatives]]></title_en><user_id>982</user_id><user_firstLast_name>Maja Katalinić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-7665</code><acronim><![CDATA[B-PaNDa]]></acronim><duration>05.12.2025 - 04.12.2028</duration><status>U tijeku</status><financ_value>200.000,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, Kemija, </scie_field_hr><scie_field_en>Biology, Chemistry, </scie_field_en><institution_hr><![CDATA[Institut za medicinska istraživanja i medicinu rada]]></institution_hr><institution_en><![CDATA[Institute for Medical Research and Occupational Health]]></institution_en><team_members_id>3033, 1099, 19641, 869802, 865748, 865786, 2757, 2735, 22563, 865931, </team_members_id><team_members_names><![CDATA[Suzana Žunec, Ivana Novak Jovanović, Ante Miličević, Lucija Marcelić, RENARD Pierre-Yves, Miguel Castanho, Dajana Gašo-Sokač, Valentina Bušić, Sergej Pirkmajer, Katarina Miš, ]]></team_members_names><keywords_hr><![CDATA[ionotropski receptori, monoaminooksidaze, antagonisti, stanični testovi, dizajn lijekova]]></keywords_hr><keywords_en><![CDATA[ionotropic receptors, monoamin oxidase, antagonists, cell-based assays, drug design]]></keywords_en><summary_hr><![CDATA[U okviru projekta, istražit ćemo mogućnost korištenja derivata piridina i nikotinamida (3-hidroksi-2-piridina i derivata vitamina B6 i B3) kao bioaktivnih molekula u modulaciji neurotransmisije. Ovaj izazovni cilj proizlazi iz naših istraživanja u sklopu Uspostavnog istraživačkog projekta &#39;&#39;Molekularni mehanizmi toksičnosti protuotrova i potencijalnih lijekova&#39;&#39; (HrZZ-UIP-2017-05-7260), gdje smo identificirali značajne rezultate na staničnoj razini koji ukazuju na potencijalne učinke spojeva na bazi piridina i nikotinamida na neuromodulaciju. Kako bismo odgovorili na središnje pitanje našeg projekta: I. evaluirat ćemo spojeve kao agoniste ili antagoniste za ključne receptore za prijenos signala koji kontroliraju brzu sinaptičku neurotransmisiju (nikotinski acetilkolinski receptor (nAChR), N-metil-D-aspartatni receptori (NMDAR) ili receptor a-amino-3-hidroksi-5-metil izoksazol propionske kiseline (AMPAR) i receptori 5-hidroksitriptamina (5-HT3)); II. procijenit ćemo potencijal spojeva za inhibiciju monoaminooksidaza (MAO-A/B) kao enzima odgovornih za razgradnju specifičnih neurotransmitera, kao što su serotonin, dopamin, adrenalin i noradrenalin, i III. procijenit ćemo potencijal spojeva da prijeđu krvno-moždanu barijeru i djeluju na središnji živčani sustav. Uz tri specifična cilja, testiranim spojevima ćemo odrediti citotoksičnost, miotoksičnost i genotoksičnost kako bi se eliminirali oni s potencijalnim nuspojavama i smanjili troškovi budućih pretkliničkih studija. Koristeći dobivene rezultate, provest ćemo analizu odnosa strukture i aktivnosti, a koristeći pristup medicinske kemije predvidjeli bismo nove spojeve s poboljšanom učinkovitošću, selektivnošću i sigurnosnim profilima. Ovim multidisciplinarnim pristupom, imat ćemo potpunu sliku aktivnosti naših spojeva na tri povezana neurotransmisijska sustava: kolinergički, glutamatergički i serotonergički, i zaključiti o potencijalu spojeva kao mogućih lijekova u modulaciji neurotransmisije.]]></summary_hr><summary_en><![CDATA[In the proposed project, we aim to investigate the use of newly synthesized compounds based on pyridine and nicotinamide structures (3-hydroxy-2-pyridines and derivatives of vitamins B6 and B3) as bioactive agents in modulating neurotransmission. This initiative builds naturally upon the intriguing findings regarding neuromodulatory effects at the cellular level of these compounds, which we previously identified during research funded by our Installation grant titled &#39;&#39;Molecular mechanisms underlying the toxicity of antidotes and potential drugs&#39;&#39; (HrZZ-UIP-2017-05-7260). To address the central question of our project, we will I. assess the compounds’ potential to serve as agonists or antagonists at key signal-transduction receptors involved in fast-synaptic neurotransmission (nicotinic acetylcholine receptor (nAChR), N-methyl-D-aspartate receptors (NMDAR) or a-amino-3-hydroxy-5-methylisoxazolepropionic acid receptor (AMPAR) and 5-hydroxytryptamine receptors (5-HT3)); II. assess the compounds&#39; ability to inhibit monoamine oxidase (MAO-A and MAO-B), enzymes critical for the breakdown of neurotransmitters such as serotonin, noradrenaline, and adrenaline; and III. explore the compounds&#39; potential to cross blood-brain barrier and act in the central nervous system. In addition to our three primary objectives, the compounds under study will undergo profiling for cytotoxicity, myotoxicity, and genotoxicity to eliminate those with potential adverse effects to minimize the cost of subsequent preclinical studies. Utilizing the gathered data, structure-activity relationship studies and a medicinal chemistry approach will be employed to design new compounds with enhanced efficacy, selectivity, and safety profiles. This comprehensive, multidisciplinary approach will allow us to better understand the overall activity of our compounds in cholinergic, glutamatergic, and serotonergic systems and their profiles as future drugs in neurotransmission modulation.]]></summary_en></project><project>
<id>18074</id><title_hr><![CDATA[Learning Amidst Disinformation and Social Conflict: Young People and Teachers Co-Constructing Curriculum through Transnational Dialogue (4Cs)]]></title_hr><title_en><![CDATA[]]></title_en><user_id>862</user_id><user_firstLast_name>Zrinka Ristić Dedić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-4527</code><acronim><![CDATA[]]></acronim><duration>01.12.2025 - 30.11.2030</duration><status>U tijeku</status><financ_value>60,00 eur</financ_value><scie_area_hr>Interdisciplinarno područje znanosti</scie_area_hr><scie_area_en>Interdisciplinary scientific area</scie_area_en><scie_field_hr>Obrazovne znanosti, </scie_field_hr><scie_field_en>Educational Sciences, </scie_field_en><institution_hr><![CDATA[Institut za društvena istraživanja]]></institution_hr><institution_en><![CDATA[Institute for Social Research in Zagreb]]></institution_en><team_members_id>872945</team_members_id><team_members_names><![CDATA[ Doktorand: Paula Filipec ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>18077</id><title_hr><![CDATA[Potencijal primjene plazmom aktivirane vode na funkcionalne komponente hrane ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>493</user_id><user_firstLast_name>Tomislava Vukušić Pavičić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-2441</code><acronim><![CDATA[PAWerful]]></acronim><duration>24.11.2025 - 24.11.2031</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Prehrambena tehnologija, </scie_field_hr><scie_field_en>Food technology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Food Technology and Biotechnology]]></institution_en><team_members_id>872960</team_members_id><team_members_names><![CDATA[ Doktorand: Marta Brkljačić ]]></team_members_names><keywords_hr><![CDATA[plamom aktivirana voda, stabilnost radikala, funkcionalne komponente hrane, antimikrobna svojstva, parametri kvalitete]]></keywords_hr><keywords_en><![CDATA[ PAW, rective species stability, functional food components, antimicrobial, quality parametres]]></keywords_en><summary_hr><![CDATA[Plazmom aktivirana voda (engl. Plasma activated water – PAW) dobivena je plazma pražnjenjem koje u vodi stvara  velik broj različitih reaktivnih vrsta poput iona, slobodnih radikala, te pobuđenih molekulski vrsta (kisikovih i dušikovih spojeva, vodikova peroksida, ozona, atomarnog kisika, hidroksilnog radikala itd.). Zbog novonastalog kemijskog sastava pokazuje antimikrobno djelovanje, te se može učinkovito koristiti u dezinfekcijske svrhe u prehrambenoj industriji. S obzirom da spada u ne toplinske metode pogodna je za primjenu na toplinski osjetljivoj hrani poput minimalno procesiranih proizvoda. Kroz ovaj projektni prijedlog cilj je kroz tri istraživačka razdoblja ispitati svojstva PAW te mogućnost direktne primjene na hranu. Specifičan kemijski sastav potrebno je karakterizirati, te odrediti stabilnost vode tijekom skladištenja, kao i antimikrobna svojstva na česte mikrobiološke kontaminante hrane. U drugoj fazi istraživanja potrebno je ispitati i utjecaj na funkcionalne komponente hrane (proteine, enzime, lipide i ugljikohidrate) s ciljem određivanja mogućnosti direktne primjene PAW na minimalno procesirane proizvode. U završnoj trećoj fazi istražiti će se mogućnost primjene PAW u direktnom kontaktu s hranom tijekom uranjanja (voća, povrća) i dozrijevanja (feta sir), te odrediti rok trajnosti uz praćenje parametara kvalitete minimalno procesiranih proizvoda prethodno tretiranih PAW. Uz primjenu sofisticiranih metoda, te praćenje velikog broja parametara cilj je dobiti što bolji uvid u potencijal primjene plazmom aktivirane vode u prehrambenoj industriji. ]]></summary_hr><summary_en><![CDATA[Plasma-activated water (PAW), obtained through plasma discharge, contains a variety of reactive species such as ions, free radicals, and excited molecular species (oxygen and nitrogen compounds, hydrogen peroxide, ozone, atomic oxygen, hydroxyl radicals, etc.). This unique chemical composition gives PAW antimicrobial properties, making it suitable for disinfection in the food industry. Being a non-thermal method, PAW is ideal for treating heat-sensitive foods like minimally processed products. The proposed project aims to explore PAW properties and their direct application to food over three research phases. The first phase involves characterizing the specific chemical composition of PAW, assessing its stability during storage, and evaluating its antimicrobial effectiveness against common microbiological food contaminants. In the second phase, the impact of PAW on the functional components of food (proteins, enzymes, lipids, and carbohydrates) will be examined to determine its suitability for direct application to minimally processed products. In the final third phase, the possibility of applying PAW in direct contact with food during immersion (fruit, vegetables) and ripening (feta cheese) will be investigated, and the shelf life will be determined while monitoring the quality parameters of minimally processed products previously treated with PAW. By employing sophisticated methods and monitoring numerous parameters, the project aims to gain comprehensive insights into the potential of using plasma-activated water in the food industry. ]]></summary_en></project><project>
<id>18083</id><title_hr><![CDATA[Trofički prijenos i procjena toksičnosti nanoplastike u obalnim ekosustavima]]></title_hr><title_en><![CDATA[Trophic transfer and toxicity Risk Assessment of Nanoplastics in Coastal Ecosystems]]></title_en><user_id>4961</user_id><user_firstLast_name>Daniel Mark Lyons</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-4010</code><acronim><![CDATA[T3RANCE]]></acronim><duration>08.12.2025 - 07.12.2028</duration><status>U tijeku</status><financ_value>199.999,05 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Interdisciplinarne prirodne znanosti, Kemija, Biologija, </scie_field_hr><scie_field_en>Interdisciplinary natural sciences, Chemistry, Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>17878, 28141, 870044, 870785, 870862, 870914, </team_members_id><team_members_names><![CDATA[Lara Jurković, Ivana Hazdovac, Ivan Balković, Marcelino Miguel Oliveira, Antonietta Siciliano, Pasquale Avino, ]]></team_members_names><keywords_hr><![CDATA[nanotoksikologija, nanoekotoksikologija, biomarkeri, nanočestice, farmaceutski proizvodi, more, hranidbeni lanci]]></keywords_hr><keywords_en><![CDATA[nanotoxicology, nanoecotoxicology, biomarkers, nanoparticles, pharmaceuticals, marine, food webs]]></keywords_en><summary_hr><![CDATA[Mikroplastika predstavlja sve veći teret u vodenom okolišu, no to ujedno i nije nužno posljednja faza starenja plastike u okolišu, već se ista može nastaviti razgrađivati, stvarajući na kraju polimerne čestice nanorazmjera. Iako su značajni istraživački napori bili usmjereni na razumijevanje ponašanja, utjecaja i sudbine mikroplastike u okolišu, relativno malo pozornosti je posvećeno manjim frakcijama nanoplastike prvenstveno zbog izazova u otkrivanju i analizi u složenim matricama. Stoga, koristeći multidisciplinarni pristup, T3RANCE ima za cilj pozabaviti se prazninama u znanju o utjecaju nanoplastike, kao vektora za relevantne hidrofobne organske zagađivače, na ključne morske vrste beskralješnjaka i kralješnjaka, njihovu biodistribuciju u tim vrstama te otkriti kretanje ovih čestica između trofičkih razina unutar odabranih morskih prehrambenih lanaca. Pristup koji koristi T3RANCE obuhvaća nekoliko uzastopnih koraka: proizvodnju nanoplastike razgradnjom netaknutih uzoraka i uzoraka sakupljenih na terenu, kao i sintezu odgovarajuće nanoplastike koja će biti označena; fizikalno-kemijska karakterizacija ovih materijala naprednim tehnikama; određivanje njihovih profila toksičnosti u vrstama koje zauzimaju ključne niše u morskom ekosustavu korištenjem najsuvremenijih višeslojnih strategija ispitivanja; i procjena kinetike i količine unosa ovih materijala u organizme u rasponu od bakterija do riba, kao i njihove sposobnosti bioakumulacije, i potencijalno biomagnifikacije, na različitim trofičkim razinama u nekoliko morskih prehrambenih lanaca. U konačnici, ovaj interdisciplinarni projekt spaja stručnost u organskoj i morskoj kemiji, biologiji, toksikologiji, molekularnoj biologiji i ekologiji kako bi pružio holistički pogled na ponašanje i sudbinu nanoplastike u obalnom okolišu, te dodao ključno znanje o utjecaju ovih materijala na antropogeno opterećen ekosustav, i krajnje ljudsko zdravlje.]]></summary_hr><summary_en><![CDATA[Microplastics present an ever-growing burden in the aquatic environment, yet these are not necessarily the final stage of plastics environmental aging, but rather may in turn continue to be degraded, eventually forming nano-scale polymer particles. While significant research efforts have focussed on understanding the behaviour, impact and fate of microplastics in the environment, relatively little attention has been paid to the smaller nanoplastic fractions primarily due to challenges in detection and analysis in complex matrices. Therefore, taking a multidisciplinary approach, T3RANCE aims to address knowledge gaps on the impact of nanoplastics, as vectors for relevant hydrophobic organic pollutants, on key invertebrate and vertebrate marine species, their biodistribution in those species and to uncover movement of these particles among trophic levels within selected marine food chains. The approach that T3RANCE takes encompasses several sequential steps: production of nanoplastics by degradation of both pristine and field-collected samples as well as the synthesis of corresponding nanoplastics incorporating labels; physicochemical characterisation of these materials by advanced techniques; determination of their toxicity profiles in species occupying key niches in the marine ecosystem using state of the art tiered testing strategies; and assessment of the kinetics and quantity of uptake of these materials in organisms ranging from bacteria to fish, as well as their ability to bioaccumulate, and potentially biomagnify, at different trophic levels in several marine food chains. Ultimately, this interdisciplinary project brings together expertise in organic and marine chemistry, biology, toxicology, molecular biology and ecology to provide a holistic view of the behaviour and fate of nanoplastics in the coastal environment, and add key knowledge on the impact of these materials in an anthropogenically-burdened ecosystem, and eventually on human health.]]></summary_en></project><project>
<id>18087</id><title_hr><![CDATA[Dizajn i 3D-ispis mikroreaktorskih sustava za Industriju 4.0]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5338</user_id><user_firstLast_name>Domagoj Vrsaljko</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-4318</code><acronim><![CDATA[INDIGO]]></acronim><duration>12.11.2025 - 11.11.2031</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Kemijsko inženjerstvo, </scie_field_hr><scie_field_en>Chemical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet kemijskog inženjerstva i tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Chemical Engineering and Technology]]></institution_en><team_members_id>872891</team_members_id><team_members_names><![CDATA[ Doktorand: Lara Štorga ]]></team_members_names><keywords_hr><![CDATA[procesno inženjerstvo, industrijski dizajn, 3D-ispis, mikroreaktorski sustavi, Industrija 4.0, inženjerstvo materijala]]></keywords_hr><keywords_en><![CDATA[process engineering, industrial design, 3D printing, microreactor systems, Industry 4.0, materials engineering]]></keywords_en><summary_hr><![CDATA[Tehnologija 3D-ispisa je relativno jeftina, automatizirana i prilagodljiva metoda koja omogućuje sintetskim laboratorijima i malim tvrtkama da dobiju pristup alatima kemijskog inženjerstva koji se obično koriste samo u velikim industrijskim okruženjima.Ovaj projektni prijedlog predstavlja nastavak istraživanja provedenog u našem prethodnom projektu HRZZ-a „Development of materials for 3D printing of microreactors“ (3Dmicroreactors). Projekt 3Dmicroreactors je riješio mnoge probleme i stvorio nove zanimljive izazove, koji su identificirani kao šest ciljeva koje ćemo rješiti ovim projektom.Cilj projekta INDIGO je istražiti i razviti metode 3D-ispisa za proizvodnju kompliciranih mikrosustava kao što su mikroreaktori i separatori za upotrebu u protočnoj kemiji.Kako bi pravilno funkcionirali, kontinuirani kemijski procesi moraju se nadzirati on-line in situ postavljenim senzorima. Budući da je većina kemijskih procesa šaržni proces, analize se obično provode nakon završetka procesa. Uz sve veći broj reakcija koje se izvode kao protočna kemija, on-line in situ mjerenja postaju sve zanimljivija znanstvenicima. Novi sustavi s integriranim sondama za on-line in situ mjerenja bit će dizajnirani i 3D-ispisani.Jedan od tipičnih problema s in situ mjerenjima je zaprljanje sonde senzora zbog prianjanja reaktanata i/ili produkata reakcije. Kako bi se riješio problem onečišćenja i poboljšala kontrola reakcije, testirat će se novi dizajni reaktora i modifikacije površine.]]></summary_hr><summary_en><![CDATA[3D printing technology is a relatively cheap, automated, and customizable method that allows synthetic laboratories and small businesses to gain access to chemical engineering tools that are typically only used in large-scale industrial settings.This project proposal represents a continuation of research conducted in our previous HRZZ project, &#39;&#39;Development of Materials for 3D Printing of Microreactors&#39;&#39; (3Dmicroreactors). 3Dmicroreactors solved many problems and created new interesting challenges, which were identified as six objectives we will solve in this project.The aim of the project, INDIGO, is to research and develop 3D printing methods for manufacturing complicated microsystems such as microreactors and separators for use in flow chemistry.To function properly, continuous chemical processes must be monitored online by in situ positioned sensors. Since most chemical processes are batch processes, analyses are usually performed after the process is completed. With the increasing number of reactions performed as flow chemistry, the on-line in situ measurements are becoming more and more interesting for scientists. New systems with integrated probes for on-line in situ measurements will be designed and 3D printed.One of the typical problems with in situ measurements is fouling of the sensor probe due to adhesions of reactants and/or reaction products. To solve the problem of fouling and improve reaction control, new reactor designs and surface modifications will be tested.]]></summary_en></project><project>
<id>18088</id><title_hr><![CDATA[Optimizacija parametarski ovisnih sustava s primjenama]]></title_hr><title_en><![CDATA[Optimization of parameter-dependent systems with applications]]></title_en><user_id>844</user_id><user_firstLast_name>Zoran Tomljanović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-4862</code><acronim><![CDATA[OPT-PEDESTAL]]></acronim><duration>01.12.2025 - 30.11.2028</duration><status>U tijeku</status><financ_value>89.585,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Fakultet primijenjene matematike i informatike]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, School of Applied Mathematics and Informatics]]></institution_en><team_members_id>25877, 22601, 869498, </team_members_id><team_members_names><![CDATA[Serkan Gugercin, Matea Ugrica Vukojević, Petar Mlinarić, ]]></team_members_names><keywords_hr><![CDATA[Parametarski ovisni sustavi, smanjenje reda modela, optimizacija prigušenja, raspršenje dva tijela, LTI sustavi]]></keywords_hr><keywords_en><![CDATA[Parameter-dependent system, Model Order Reduction, damping optimization, two-body scattering, LTI systems]]></keywords_en><summary_hr><![CDATA[Parametarski ovisni sustavi imaju ključnu ulogu u raznim istraživačkim područjima, uključujući matematiku, inženjering i fiziku, jer se pojavljuju u aplikacijama koje uključuju analizu parametara i optimizaciju. Ovaj projekt proučava sustave sa strukturiranim varijacijama parametara, s naglaskom na optimizaciju prigušenja u parcijalnim i običnim diferencijalnim jednadžbama (PDE-i i ODE-i). Također istražuje metode smanjenja reda modela (MOR) kako bi se poboljšala učinkovitost analize parametara u strukturiranim parametarskim sustavima. Glavna primjena je optimizacija prigušenja, gdje parametri određuju poziciju prigušenja (geometriju) te viskoznosti. Druga ključna primjena dolazi iz nuklearne fizike, gdje ćemo proučavati nuklearno raspršenje dva tijela pomoću radijalne Schrödingerove jednadžbe i jednadžbi toka slične renormalizacije. Kako bi poboljšali učinkovitost, primijenit ćemo MOR za analizu dinamike sustava, optimizaciju parametara i primjenu rezultata na važne stvarne primjene. Cilj ovog projekta je razviti nove modele i ubrzati izračun raznih kriterija optimizacije prigušenja. Naš pristup integrira nove teorijske rezultate kako bi osigurao brže konvergiranje metoda i preciznije izračune funkcija cilja. Ovo istraživanje fokusira se na četiri ključne teme: i) Optimizacija prigušenja na razini PDE-a, ii) Optimizacija prigušenja za LTI sustave, iii) MOR za parametarski ovisne sustave i iv) MOR pristupi u praktičnim primjenama. Naš rad uvest će nove perspektive modeliranja i metodologije koje konkuriraju postojećim tehnikama, čime će dodatno unaprijediti ovo područje. Ovo istraživanje je ključno za učinkovitu analizu parametara u strukturiranim parametriranim sustavima. Osim toga, ovo istraživanje integrirat će najnovija numerička računanja, iskorištavajući sinergiju između novih teorijskih uvida i strukturiranih MOR tehnika kako bi poboljšali učinkovitost računanja.]]></summary_hr><summary_en><![CDATA[Parameter-dependent systems play a crucial role in various research fields, including mathematics, engineering, and physics, as they arise in applications involving parameter analysis and optimization.   This project examines systems with structured parameter variations, emphasizing damping optimization in partial and ordinary differential equations (PDEs and ODEs). It also explores Model Order Reduction (MOR) methods to enhance the efficiency of parameter analysis in structured parametric systems. A primary application is damping optimization, where parameters govern both the damping position (geometry) and viscosity. Another key application comes from nuclear physics, where we will study nuclear two-body scattering using the radial Schrödinger equation and similarity renormalization group flow equations. To enhance efficiency, we will apply Model Order Reduction (MOR) methods to analyze system dynamics, optimize parameters, and apply the results to significant real-world applications such as those stated above. This project aims to develop new models and accelerate the calculation of various damping optimization criteria in real-world applications. Our approach integrates innovative theoretical insights to ensure faster convergence and more precise evaluations of objective functions. This research focuses on four key topics:   i) Damping optimization at the PDE level,   ii) Damping optimization for LTI systems,   iii) MOR for parameter-dependent systems, and  iv) MOR approaches in practical applications.   Our work will introduce novel modeling perspectives and methodologies that rival existing techniques, and thus further advancing the field. This research is crucial for efficient parameter analysis in structured parametric systems. Additionally, this research will integrate cutting-edge numerical computations, leveraging the synergy between new theoretical insights and structured MOR techniques to enhance computational efficiency.]]></summary_en></project><project>
<id>18089</id><title_hr><![CDATA[Eko-asfaltni slojevi posebne namjene izvedeni po hladnom postupkom uz smanjenu emisiju CO2]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4188</user_id><user_firstLast_name>Nikola Sakač</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-3212</code><acronim><![CDATA[]]></acronim><duration>24.11.2025 - 23.11.2031</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Geotehnički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Geotechnical Engineering]]></institution_en><team_members_id>872914</team_members_id><team_members_names><![CDATA[ Doktorand: Martina Habulan ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>18095</id><title_hr><![CDATA[Šećerna bolest počinje u crijevima: Analiza uloge crijevnog mikrobioma, prehrambenih navikama i psihičkog stresa u šećernoj bolesti tip 2]]></title_hr><title_en><![CDATA[Diabetes begins in the gut: The analysis of the role of the gut microbiome, dietary habits and psychological stress in type 2 diabetes]]></title_en><user_id>182</user_id><user_firstLast_name>Tina Tičinović Kurir</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-6586</code><acronim><![CDATA[DIAMICROBIOM]]></acronim><duration>31.12.2025 - 30.12.2028</duration><status>U tijeku</status><financ_value>199.604,00 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Clinical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Split School of Medicine]]></institution_en><team_members_id>118, 19978, 5731, 94, 870134, 19985, 870388, </team_members_id><team_members_names><![CDATA[Tatijana Zemunik, Ivica Šamanić, Ana Maravić, Mladen Krnić, Maja Mizdrak, Ines Bilić-Ćurčić, Silvija Canecki-Varžić, ]]></team_members_names><keywords_hr><![CDATA[šećerna bolest tip 2, crijevni mikrobiom, mediteranska prehrana, posttraumatski stresni poremećaj, kardiovaskularni rizik, strojno učenje ]]></keywords_hr><keywords_en><![CDATA[Type 2 Diabetes, gut microbiome , Mediterranean diet,  post-traumatic stress disorder, cardiovascular  risk, machine learning ]]></keywords_en><summary_hr><![CDATA[Unatoč tomu što šećerna bolest tip 2 (lat. diabetes mellitus typus 2, DM2) predstavlja veliki javnozdravstveni problem, mehanizmi razvoja DM2 i dalje su velikim dijelom nepoznati. Ipak, rastu dokazi da je važan patofiziološki mehanizam DM2 narušena homeostaza crijevnog mikrobioma. Glavni cilj projekta je sveobuhvatno analizirati sastav crijevnog mikrobioma i povezanost s različitim obrascima prehrambenih navika u bolesnika s DM2. Ispitat ćemo utjecaj pridržavanja mediteranske prehrane na sastav crijevnog mikrobioma i kardiovaskularni rizik u ispitanika s DM2 koji žive na dalmatinskim otocima u odnosu na utjecaj kontinentalne prehrane u stanovnika koji žive u istočnoj Hrvatskoj i kontinentalnom dijelu Dalmacije. Kao kontrolne skupine uključit će se bliski članovi obitelji koji nemaju šećernu bolest, a imaju iste prehrambene obrasce. S obzirom na prepoznatu nepovoljnu ulogu psihičkog stresa na sastav crijevnog mikrobioma i patogenezu DM2, analizirat ćemo utjecaj posttraumatskog stresnog poremećaja (PTSP) na sastav crijevnog mikrobioma i kardiovaskularni rizik u ratnih veterana s dijagnozom PTSP-a i DM2. Analiza uloge crijevnog mikrobioma, prehrambenih navika i psihičkog stresa u DM2 uz izradu modela strojnog učenja, pružit će mogućnost translacije spoznaja i unaprjeđenje personalizirane brige za zdravlje osoba s DM2, kao i za postizanje znanstvenog doprinosa uz dalekosežne pozitivne društvene i gospodarske učinke. ]]></summary_hr><summary_en><![CDATA[Type 2 diabetes (lat: diabetes mellitus typus 2, DM2) is a significant public health concern, yet the mechanisms underlying its development remain largely unclear. However, increasing evidence suggests that impaired homeostasis of the gut microbiome plays a crucial role in the pathophysiology of DM2. The primary goal of this study is to analyze the composition of the gut microbiome and its association with various dietary habits in patients with DM2. We will examine the impact of the Mediterranean diet on gut microbiome composition and cardiovascular risk among residents of the Dalmatian islands and compare these effects with those of a continental diet in residents of eastern Croatia and the continental part of Dalmatia. Additionally, family members of subjects without diabetes but sharing similar dietary habits will serve as a control group. Recognizing the negative impact of psychological stress on gut microbiome composition and the development of DM2, we will also investigate how post-traumatic stress disorder (PTSD) affects gut microbiome composition and cardiovascular risk in war veterans who have both PTSD and DM2. By analyzing the roles of the gut microbiome, dietary habits, and psychological stress in DM2, and developing a machine-learning model, we aim to enhance personalized medical care for individuals with DM2 and enable the translation of knowledge. This research has the potential to contribute scientifically with far-reaching positive social and economic effects.]]></summary_en></project><project>
<id>18096</id><title_hr><![CDATA[Proteinski hidrolizati kao prirodni preparati u održivom maslinarstvu]]></title_hr><title_en><![CDATA[]]></title_en><user_id>12403</user_id><user_firstLast_name>Igor Pasković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-7450</code><acronim><![CDATA[PROGRESS]]></acronim><duration>11.11.2025 - 10.11.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Institut za poljoprivredu i turizam]]></institution_hr><institution_en><![CDATA[Institute of Agriculture and Tourism in Poreč]]></institution_en><team_members_id>872908</team_members_id><team_members_names><![CDATA[ Doktorand: Nataly Milovan ]]></team_members_names><keywords_hr><![CDATA[Biostimulans, proteini, enzimska hidroliza, gljivična infekcija, otpornost biljaka, rendgenska fluorescencija, ATR-FTIR mikroskopija, MeV-SIMS]]></keywords_hr><keywords_en><![CDATA[Biostimulant, proteins, enzymatic hydrolysis, fungal infection, plant resistance, X-ray fluorescence, ATR-FTIR microscopy, MeV-SIMS]]></keywords_en><summary_hr><![CDATA[Ključni izazov moderne poljoprivrede je povećati produktivnost uz istovremeno smanjenje negativnih utjecaja na okoliš i zdravlje ljudi. Biostimulansi su spojevi koji pozitivno utječu na kondiciju i otpornost biljaka na štetnike bez negativnog utjecaja na okoliš i predstavljaju zelenu alternativu sintetskim kemikalijama koje se koriste u ishrani i zaštiti bilja. Cilj projekta je dizajnirati nove biostimulanse iz lista masline, koji je nusprodukt proizvodnje maslinovog ulja, za primjenu u održivom maslinarstvu. Provodit će se dva glavna eksperimenta. U prvom će se ocjenjivati učinak proteinskih hidrolizata (PH) na rast sadnica masline i kemijski sastav njihovih tkiva. U drugom pokusu PH će se primijeniti na odraslim stablima maslina te će se pratiti njihov učinak na biljku kroz razlike u sastavu minerala te primarnih i sekundarnih metabolita u listu. Utvrdit će se i količina i kvaliteta maslinovog ulja. Nadalje, dubina prodiranja folijarno primijenjenih PH proučavat će se korištenjem molekularnog snimanja (prigušena totalna Fourier-transformirana infracrvena mikroskopija i masena spektrometrija sekundarnih molekularnih iona) kojima će se, nakon prikaza raspodjele minerala (mikročesticama inducirana emisija rendgenskoga zračenja) omogućiti utvrđivanje načina djelovanja PH. Struktura tako identificiranih PH bit će potvrđena usporedbom njihovih spektara nuklearne magnetske rezonancije i masenih spektara s onima sintetiziranih peptida. Na kraju će se ispitati učinak PH na bolest paunovog oka pri čemu će se utvrditi redistribucija elemenata oko simptomatskih nekrotičnih točaka. Projektni tim je visoko interdisciplinaran, a dobiveni će rezultati uvelike služiti biljnim biolozima, agronomima, poljoprivrednicima i nutricionistima. Projekt će omogućiti promicanje važnosti ekološki prihvatljivih preparata, opsežnu razmjenu znanja i omogućit će izobrazbu doktoranada i poslijedoktoranada koji će steći jedinstven skup vještina i imati pristup najsuvremenijim tehnologijama.]]></summary_hr><summary_en><![CDATA[A key challenge of modern agriculture is to increase productivity while reducing negative impacts on the environment and human health. Biostimulants are compounds which have a positive impact on plant fitness and resistance to pests without harming the environment and represent a green alternative to synthetic chemicals used in plant nutrition and protection. The aim of the project is to design a novel biostimulant originating from olive leaves, which are by-products of olive oil industry, and to use them in sustainable olive production. Particularly, two main experiments will be performed. In the first, protein hydrolysates’ (PHs) effect on the growth of olive seedlings and chemical composition of their tissues will be evaluated. In the second experiment PHs will be applied on mature olive trees and plants’ performance will be monitored through the differences in composition of minerals and primary and secondary metabolites and the amount and quality of olive oil will be determined. Furthermore, the penetration depth of foliarly applied PHs will be studied using molecular imaging (Attenuated Total Reflection-Fourier Transform Infrared microscopy and MeV-Secondary Ion Mass Spectrometry) which will, accompanied by mineral distribution imaging (micro-Particle-Induced X-ray Emission), enable resolving the mode-of-action of the PHs. Structure of so identified PHs will be confirmed by comparing their nuclear magnetic resonance and mass spectra with those of synthesized peptides. Finally, PHs effect on olive spot disease will be tested, where redistribution of elements around the symptomatic necrotic spots will be determined. The project will engage an interdisciplinary team to deliver knowledge required by plant biologists, agronomists, farmers and nutritionists. It will enable promote the importance of green tools, the extensive knowledge exchange and will allow training of PhD and postdoc students to obtain unique set of technical skills in cutting-edge technologies.]]></summary_en></project><project>
<id>18101</id><title_hr><![CDATA[Razvoj modela umjetne inteligencije za detekciju pedijatrijskih fraktura kostiju i utjecaj istih na kliničku praksu]]></title_hr><title_en><![CDATA[Development of artificial intelligence models for the detection of pediatric bone fractures and its impact on clinical practice]]></title_en><user_id>25743</user_id><user_firstLast_name>Franko Hržić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2025-02</proposal_call><code>UIP-2025-02-6365</code><acronim><![CDATA[FRACT-AID]]></acronim><duration>19.02.2026 - 18.02.2031</duration><status>U tijeku</status><financ_value>203.722,50 eur</financ_value><scie_area_hr>Interdiciplinarne znanosti, Tehničke znanosti, Biomedicina i zdravstvo, </scie_area_hr><scie_area_en>Interdisciplinary scientific area, Technological sciences, Biomedicine and health sciences, </scie_area_en><scie_field_hr>Interdisciplinarne tehničke znanosti, Računarstvo, Temeljne tehničke znanosti, Temeljne medicinske znanosti, Kliničke medicinske znanosti, Biotehnologija u biomedicini, </scie_field_hr><scie_field_en>Interdisciplinary technological sciences, Computer sciences, Basic engineering sciences, Basic Medical Sciences, Clinical sciences, Biotechnology in Biomedicine, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Tehnički fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Engineering]]></institution_en><team_members_id>870731, 25872, 870844, 868766, 865061, </team_members_id><team_members_names><![CDATA[Nikola Lopac, Sebastian Tschauner, Ana Trisovic, Boris Gašparović, Mateja Napravnik, ]]></team_members_names><keywords_hr><![CDATA[Umjetna inteligencija, Medicina, Radiologija, Pedijatrijske Frakture, Duboko učenje, CBIR, Detekcija objekata, Klinička primjena, AI u Medicini, X-ray]]></keywords_hr><keywords_en><![CDATA[Artificial Intelligence, Medicine, Radiology, Pediatric Fractures, Deep Learning, CBIR, Object Detection, Clinical Application, AI in Medicine, X-ray]]></keywords_en><summary_hr><![CDATA[Prijelomi kostiju (frakture) se definiraju kao prekidi kontinuiteta korteksa kosti, često praćeni ozljedama mekih tkiva. U šest najvećih europskih zemalja godišnje se zabilježi preko 2.7 milijuna slučajeva fraktura izdvajajući čak 3.5% sredstava iz budžeta zdravstva Europske unije (EU27+2). Razvojem dubokih neuronskih mreža i umjetne inteligencije veliki broj istraživanja usredotočio se na klasifikaciju, detekciju i segmentaciju fraktura s rentgenskih slika s ciljem razvoja programa i alata koje će pomoći radiolozima u postavljanju dijagnoza. Unatoč velikom broju razvijenih modela i temeljnih modela strojnog učenja u području medicine, utjecaj umjetne inteligencije na kliničku praksu ostaje nedefiniran i neistražen.Kako bi se ispitala postavljena hipoteza „Informacije dobivene AI modelom o frakturama imaju pozitivan utjecaj na performanse radiologa i dijagnostiku pacijenta“  tijekom projekta će se razviti posebno dizajnirani model za detekciju pedijatrijskih fraktura treniran na prikupljenom i označenom skupu podataka od preko 180,000 pedijatrijskih rendgenskih slika iz Sveučilišne bolnice u Grazu. Nakon detekcije fraktura, koristeći metodu povratka sličnih slučajeva na temelju značajki prvo će se ekstrahirati značajke iz radiograma, regije frakture, dijagnoze i karakteristike slike, a potom će se razviti inovativni model koji će ekstrahirane značajke povezati u jedan zajednički prostor u kojemu će se lako moći spariti slični slučajevi. Ovakav pristup pruža veliki korak ka personaliziranoj medicini budući da će radiolog, uz detektiranu regiju frakture, imati uvid i u slučajeve slične onom promatranom. Na posljetku će se provesti kliničko istraživanje u bolnici kako bi se ispitali benefiti razvijenih modela za radiologe i pacijente. Ovo istraživanje pruža iskorak u detekciji pedijatrijskih fraktura te otvora potencijal za razvoj softvera koji može utjecati na kliničku praksu i doprinijeti unapređenju zdravstvene skrbi.]]></summary_hr><summary_en><![CDATA[Bone fractures are defined as breaks in the continuity of the bone cortex, often accompanied by soft tissue injuries. In the six largest European countries, over 2.7 million fracture cases are recorded annually, with as much as 3.5% of the European Union’s (EU27+2) healthcare budget allocated to this problem. With the development of deep neural networks and artificial intelligence, many studies have focused on the classification, detection, and segmentation of fractures from X-ray images, aiming to develop software and tools to assist radiologists in making accurate diagnoses. Despite the plethora of developed models and fundamental machine learning models in medicine, the impact of artificial intelligence on clinical practice remains undefined and underexplored.To test the hypothesis “Information obtained by the AI model on fractures has a positive impact on radiologists’ performance and patient diagnosis,” the project will develop a specially designed model for detecting pediatric fractures, trained on a collected and labeled dataset of over 180,000 pediatric X-ray images from the University Hospital in Graz. After fracture detection, a method for content-based case retrieval will first extract characteristics from the radiograph, the fracture region, the diagnosis, and the image attributes. Then, an novel model will be developed to integrate these extracted features into a common space where similar cases can be easily matched. This approach represents a significant step toward personalized medicine, as it will provide the radiologist not only with the detected fracture region but also with insight into similar cases.Finally, a clinical study will be conducted in the hospital to assess the benefits of the developed models for both radiologists and patients. This research represents a step forward in pediatric fracture detection and opens the potential to develop a software that can influence clinical practice and contribute to the improvement of healthcare.]]></summary_en></project><project>
<id>18102</id><title_hr><![CDATA[Kognitivna kontrola i socijalna kognicija od adolescencije do odrasle dobi: razvojna perspektiva]]></title_hr><title_en><![CDATA[Cognitive Control and Social Cognition from Adolescence to Adulthood: A Developmental Perspective]]></title_en><user_id>26004</user_id><user_firstLast_name>Martina Knežević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2025-02</proposal_call><code>UIP-2025-02-9870</code><acronim><![CDATA[CASCADE]]></acronim><duration>30.03.2026 - 29.03.2031</duration><status>U tijeku</status><financ_value>157.697,95 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Psihologija, Interdisciplinarne društvene znanosti, </scie_field_hr><scie_field_en>Psychology, Interdisciplinary social sciences, </scie_field_en><institution_hr><![CDATA[Hrvatsko katoličko sveučilište, Zagreb]]></institution_hr><institution_en><![CDATA[Catholic University of Croatia]]></institution_en><team_members_id>20236, 870643, </team_members_id><team_members_names><![CDATA[Ivana Hanzec Marković, Ana Haramina, ]]></team_members_names><keywords_hr><![CDATA[kognitivna kontrola, socijalna kognicija, normalni razvoj, adolescencija, rana odrasla dob]]></keywords_hr><keywords_en><![CDATA[cognitive control, social cognition, typical development, adolescence, early adulthood]]></keywords_en><summary_hr><![CDATA[Adolescencija je fascinantno i važno razdoblje života kroz koje svi moramo proći kako bismo postali samostalni odrasli. Nedavni nalazi pokazuju da neke strukture mozga ne sazrijevaju u potpunosti do približne dobi od 25 godina. Ovaj projekt usmjeren je na dva istraživačka pitanja: (1) Koja je neurofiziološka podloga i kakve su bihevioralne karakteristike kognitivnog sazrijevanja u adolescenata i mladih normalnog razvoja? (2) Postoji li napredak u zauzimanju perspektive između adolescencije i rane odrasle dobi? Trenutno ne postoji sveobuhvatna teorija koja bi uključila nedavne neuroznanstvene nalaze o produljenom sazrijevanju mozga kroz adolescenciju i ranu odraslu dob u okviru klasičnih razvojnih kognitivnih teorija i ostaje jaz između našeg znanja o sazrijevanju mozga i kognitivnom razvoju nakon djetinjstva. Osim toga, dok se veliki broj istraživača usmjerio na razvoj socijalne spoznaje tijekom djetinjstva i njenog oštećenja kod različitih poremećaja, samo je nekolicina istraživala razvoj kod zdravih adolescenata, a gotovo da uopće nije proučavan razvoj u ranoj odrasloj dobi (tj. početkom 20-ih). Pomoću baterije neuropsiholoških testova, socio-kognitivnih zadataka i elektroencefalografije planiramo uključiti adolescente (u dobi od 14 do 17 godina), rane odrasle osobe (u dobi od 18 do 24 godine) i odrasle osobe (u dobi od 25 do 35 godina) kako bismo istražili njihove psihološke, društvene i kognitivne karakteristike, kao i neurološke temelje tih procesa te provjerili učinke povezane s dobi. Rezultati ovog projekta mogli bi imati značajan utjecaj na razumijevanje jedinstvenih prednosti i ranjivosti adolescenata i mladih osoba te bolje informirati politike i tretmane usmjerene na podupiranje pozitivnijeg razvoja mladih.]]></summary_hr><summary_en><![CDATA[Adolescence is a fascinating and important period of life through which we all must go through to become independent adults. Recent findings show that some brain structures do not fully mature until the approximate age of 25. This project focuses on two research questions: (1) What are the neurophysiological underpinnings and behavioural characteristics of cognitive maturation in typically developing adolescents and early adults? (2) Are there improvements in perspective taking between adolescence and early adulthood? Currently there is no comprehensive theory that would incorporate recent neuroscientific findings about continued brain maturation across adolescence and early adulthood in the framework of classic developmental cognitive theories and a gap remains between our knowledge of brain maturation and cognitive development after childhood. In addition, while number of researchers have focused on the development of social cognition during childhood and its impairments in mental and neurodevelopmental disorders, only a handful considered its development in typical adolescents and almost non studied its development in early adulthood (i.e., early 20s). Using neuropsychological testing battery, social and cognitive tasks and electroencephalography, we plan to include adolescents (aged 14 to 17 years), early adults (aged 18 to 24 years) and adults (aged 25 to 35 years) to investigate their psychological, social and cognitive characteristics as well as the neural underpinnings of these processes to explore age-related effects. The results of this project might have a profound impact on understanding of the unique strengths and vulnerabilities of adolescents and early young adults, and better inform policies and treatments aimed at supporting more positive youth development.]]></summary_en></project><project>
<id>18109</id><title_hr><![CDATA[Oštećenje DNA i diferencijacija akutne mijeloične leukemije]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4677</user_id><user_firstLast_name>Dora Višnjić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-6776</code><acronim><![CDATA[DD&D_in_AML]]></acronim><duration>15.11.2025 - 14.11.2031</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>872941</team_members_id><team_members_names><![CDATA[ Doktorand: Klara Bardač ]]></team_members_names><keywords_hr><![CDATA[AML, oštećenje DNA, Chk1, AIKAr, pirimidin, citarabin]]></keywords_hr><keywords_en><![CDATA[AML, DNA damage, Chk1, AICAr, pyrimidine, cytarabine]]></keywords_en><summary_hr><![CDATA[Glavno obilježje akutne mijeloične leukemije (AML) je izostanak diferencijacije pa je stoga poticanje diferencijacije izgledni pristup liječenju. Najuspješniji primjer diferencirajućeg liječenja je liječenje akutne promijelocitne leukemije (APL) pomoću sve-trans retinske kiseline (ATRA). Nedavni uspjeh inhibitora mutirane izocitrat-dehidrogenaze obnovio je zanimanje za diferencirajuće liječenje, a učinci inhibitora dihidroorotat-dehidrogenaze (DHODH) se aktivno istražuju.  Naša istraživačka skupina ima dugogodišnje iskustvo u istraživanju mehanizama diferencijacije leukemija. Naša nedavna istraživanja otkrila su da  5-aminoimidazol-4-karboksiamid ribonukleozid (AICAr) potiče diferencijaciju monocitnih linija AML te podskupine primarnih blasta izoliranih iz koštane srži (KS) oboljelih od AML. AIKAr koči sintezu pirimidina nizvodno od  DHODH i potiče diferencijaciju aktivacijom kinaze Chk1 i signalnoga puta oštećenja DNK, a isti se put aktivira i tijekom diferencijacije potaknute citarabinom, uobičajenim citotoksičnom lijekom.Različiti čimbenici in vivo doprinose izostanku translacije pretkliničkih otkrića u uspješno kliničko liječenje, kao što su učinci mikrookoliša KS, relaps bolesti i manjak prediktivnih molekularnih markera u oboljelih. U ovome projektu planiramo odrediti učinke strome KS na diferencijaciju AML, odrediti poremećaje nukleotida koji potiču put oštećenja DNK te nizvodne ciljeve aktivirane Chk1, uspostaviti model blasta AML ex vivo koji će bolje probirati oboljele koji odgovaraju na diferencirajuće liječenje te sekvencioniranjem uzoraka primarnih blasta odrediti biomarkere osjetljivosti na lijekove. U konačnici, razvit ćemo mišji model koji omogućava testiranje učinaka lijekova in vivo. Ovaj projekt okuplja stručnjake u područjima kliničke i eksperimentalne hematologije kako bi odredili mehanizme diferencijacije AML te razvili modele i alate koji mogu pomoći probiru oboljelih od AML koji odgovaraju na diferencirajuće liječenje. ]]></summary_hr><summary_en><![CDATA[Lack of differentiation is a hallmark of acute myeloid leukemia (AML) making therapy aimed at differentiation a promising strategy. The most successful example of differentiation therapy is all-trans retinoic acid (ATRA)-based treatment of acute promyelocytic leukemia (APL). The recent success of inhibitors of mutated isocitrate dehydrogenase revived interest in differentiation therapy, and dihydroorotate dehydrogenase (DHODH) inhibitors are being actively explored.Our team has a long-standing experience in studying leukemia differentiation. Our recent studies revealed that 5-aminoimidazole-4-carboxamide ribonucleoside (AICAr) induced differentiation of monocytic AML cell lines and a subset of primary blasts isolated from the bone marrow (BM) of AML patients. AICAr inhibits pyrimidine synthesis downstream of DHODH and induces differentiation by activating Chk1 and DNA damage signalling pathway. The same pathway is activated during differentiation induced by cytarabine, a commonly used cytotoxic drug.Several factors in vivo contribute to the failure to translate preclinical findings to a clinically successful strategy, including the role of the BM microenvironment, relapse of the disease and the lack of predictive molecular markers in patients. In this project, we propose to: determine the effects of BM stroma on AML differentiation, identify nucleotide disturbances that activate DNA damage pathway, identify downstream targets of activated Chk1, develop a model of primary AML blasts ex vivo for better screening for differentiation and to determine molecular biomarkers for drug sensitivity using sequencing of primary blasts. Finally, we will develop a mouse model that allows testing the effects of drugs in vivo.This grant brings together experts in the field of clinical and experimental hematology in order to define the mechanisms of AML differentiation and to develop models and tools that could help to identify AML patients who respond to differentiation therapy.]]></summary_en></project><project>
<id>18110</id><title_hr><![CDATA[Evaluacija velikih jezičnih modela s dohvatom znanja]]></title_hr><title_en><![CDATA[Evaluation of Retrieval-Augmented Large Language Models]]></title_en><user_id>4894</user_id><user_firstLast_name>Marina Bagić Babac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-1267</code><acronim><![CDATA[EVALLA]]></acronim><duration>22.12.2025 - 21.12.2028</duration><status>U tijeku</status><financ_value>199.933,50 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>869408, 870570, 2994, </team_members_id><team_members_names><![CDATA[Andrej Slapničar, Antun Drobnjak, Vedran Mornar, ]]></team_members_names><keywords_hr><![CDATA[Obrada prirodnog jezika, veliki jezični modeli, evaluacija modela, dohvat znanja, umjetna inteligencija]]></keywords_hr><keywords_en><![CDATA[Natural language processing, large language models, model evaluation, knowledge retrieval, artificial intelligence]]></keywords_en><summary_hr><![CDATA[Veliki jezični modeli mijenjaju način na koji pristupamo i obrađujemo informacije, omogućujući strojevima analizu, interpretaciju i generiranje odgovora na temelju ogromnih količina znanja. Ovi modeli imaju potencijal unaprijediti obrazovanje, istraživanje i donošenje odluka pružajući korisnicima brze i relevantne uvide. Međutim, njihova pouzdanost ovisi o tome koliko učinkovito dohvaćaju i integriraju točne informacije, jer tradicionalni veliki jezični modeli ponekad mogu proizvesti netočne ili obmanjujuće rezultate. Kako bi se to prevladalo, veliki jezični modeli s dohvatom znanja kombiniraju dohvaćanje znanja s naprednim sposobnostima zaključivanja, omogućujući im pristup i korištenje vanjskih izvora u stvarnom vremenu. Time se poboljšava njihova točnost, osigurava ažurnost i povećava korisnost u različitim područjima. Projekt EVALLA posvećen je poboljšanju procjene ovih modela razvojem jasnog i standardiziranog okvira za mjerenje njihove učinkovitosti, pouzdanosti i sposobnosti integracije znanja. Osiguravanjem rigoroznog testiranja velikih jezičnih modela s dohvatom znanja, EVALLA će doprinijeti razvoju transparentnijih, pouzdanijih i korisnijih sustava temeljenih na znanju. Time će se potaknuti razvoj boljih alata u raznim područjima, osiguravajući da tehnologije temeljene na znanju podržavaju napredak, donošenje informiranih odluka i šire društvene koristi.]]></summary_hr><summary_en><![CDATA[Large language models (LLMs) are transforming how we access and process information, enabling machines to analyze, interpret, and generate responses based on vast amounts of knowledge. These models have the potential to enhance education, research, and decision-making by providing users with quick and relevant insights. However, their reliability depends on how well they retrieve and integrate factual information, as traditional LLMs can sometimes produce incorrect or misleading results. To address this, retrieval-augmented large language models (RAG LLMs) combine knowledge retrieval with advanced reasoning capabilities, allowing them to access and use external sources in real time. This improves their accuracy, keeps them up to date, and makes them more useful for different knowledge-intensive fields. The EVALLA project is dedicated to improving the evaluation of these models by developing a clear and standardized framework to assess their effectiveness, reliability, and ability to integrate knowledge. By ensuring that RAG LLMs are tested rigorously, EVALLA will contribute to the development of more transparent, trustworthy, and useful knowledge-based systems. This will contribute to the development of better tools for various fields, ensuring that knowledge-driven technologies support progress, informed decision-making, and broader societal benefits. ]]></summary_en></project><project>
<id>18112</id><title_hr><![CDATA[Kvantna memorija za pojedinačne fotone u optičkoj šupljini s membranom u sredini]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5714</user_id><user_firstLast_name>Nenad Kralj</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-4528</code><acronim><![CDATA[MIMIQ.ME]]></acronim><duration>15.01.2026 - 14.01.2032</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci]]></institution_hr><institution_en><![CDATA[University of Rijeka]]></institution_en><team_members_id>873083</team_members_id><team_members_names><![CDATA[ Doktorand: Lucija Črep ]]></team_members_names><keywords_hr><![CDATA[optomehanika, optička šupljina, šupljina s membranom u sredini, kvantna memorija, pojedinačni fotoni,]]></keywords_hr><keywords_en><![CDATA[optomechanics, optial cavity, membrane-in-the-middle cavity, quantum memory, single photons]]></keywords_en><summary_hr><![CDATA[Mnoge primjene kvantne teorije, poput kvantne kriptografije na velikim udaljenostima i međusobnog povezivanja kvantnih računala, zahtijevaju distribuciju kvantnih resursa, kao što je sprezanje. Pridruženi gubici uvjetuju potrebu za kvantnim ponavljačima, čija je ključna sastavnica kvantna memorija. Predloženi su različiti protokoli za takve memorije, ali postojeće realizacije ne uspijevaju obuhvatiti sljedeća željena svojstva u jednom sustavu: dugo vrijeme koherencije, visoka učinkovitost, očitavanje na zahtjev i kompatibilnost s C-pojasom telekomunikacija. U MIMIQ.ME, radit ćemo na razvoju memorijske platforme za pojedinačne fotone (SP) temeljene na principu optomehanički inducirane prozirnosti (OMIT), koja može funkcionirati na raznim valnim duljinama te, zajedno s odgovarajućim SP izvorom, ispuniti sve ove zahtjeve. Memorijom ćemo upravljati na sobnoj temperaturi i implementirati ju u određenom optomehaničkom sustavu, šupljini s membranom u sredini (MIM), gdje se SP-ovi pohranjuju u vibracijskom modu ultrakoherentnog meko stegnutog membranskog rezonatora. Testirat ćemo platformu pomoću optičkih pulseva, postižući rekordna vremena pohrane i učinkovitosti među optomehaničkim memorijama.Realizirat ćemo izvor najavljenih SP-ova za pohranjivanje, na temelju spontane parametarske konverzije prema dolje u nelinearnom kristalu. Rezonantno ćemo pojačati proces postavljanjem kristala u drugu optičku šupljinu kako bismo formirali optički parametarski oscilator. Nakon MIMIQ.ME, planiramo mjeriti očuvanje sprezanja između generiranih parova fotona nakon pohrane kako bismo potvrdili da sustav radi kao kvantna memorija. Gledajući dalje, on se može koristiti za pohranjivanje polarizacijskih kubita koje generiraju SP-ovi na zahtjev iz poluvodičkih kvantnih točaka, čime bi se stanje kvantnih mreža pogurnulo prema praktičnim primjenama. Koliko platforma obećava pokazuje i činjenica da pojedini MIM sustavi s meko stegnutim membranama rade u kvantnom režimu već na sobnoj temperaturi.]]></summary_hr><summary_en><![CDATA[Many applications of the quantum theory, like quantum cryptography over long distances and interconnection of quantum computers, require the distribution of quantum resources, such as entanglement. Associated losses dictate the need for quantum repeaters, a key facilitator in which is a quantum memory. Different protocols for such memories have been proposed, but existing realizations fall short of combining the following desired properties in a single system: long coherence time, high efficiency, on-demand readout and compatibility with the telecom C-band. In MIMIQ.ME, we will work on the development of a wavelength-versatile memory platform for single photons (SPs) based on the principle of optomechanically induced transparency (OMIT), which can be used in conjunction with a suitable SP source to fulfil all of these requirements. We will operate the memory at room temperature and implement it in a particular optomechanical system, the membrane-in-the-middle (MIM) cavity, where the SPs are stored in a vibrational mode of an ultracoherent soft-clamped membrane resonator. We will test the platform using optical pulses, showcasing record storage times and efficiencies among optomechanical memories.We will realize a source of heralded SPs to be stored, based on spontaneous parametric down conversion in a nonlinear crystal. We will resonantly enhance the process by placing the crystal inside another cavity to form an optical parametric oscillator. Following MIMIQ.ME, we plant to measure the preservation of entanglement between generated photon pairs after storage to confirm the system works as a quantum memory. Looking further ahead, it can be used to store polarization qubits generated by on-demand SPs from semiconductor quantum dots, propelling the state of the art of quantum networks towards practical applications. This promise is further highlighted by the fact that MIM systems with soft-clamped membranes have seen room-temperature operation in the quantum regime.]]></summary_en></project><project>
<id>18113</id><title_hr><![CDATA[Novi peptid-oligonukleotid-kromofor konjugati za biokemijsku dijagnostiku i bioaktivnost]]></title_hr><title_en><![CDATA[]]></title_en><user_id>480</user_id><user_firstLast_name>Ivo Piantanida</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-4161</code><acronim><![CDATA[POC-Sens-Bioact]]></acronim><duration>16.01.2026 - 15.01.2026</duration><status>U tijeku</status><financ_value>60,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>873012</team_members_id><team_members_names><![CDATA[ Doktorand: Petra Katalinić ]]></team_members_names><keywords_hr><![CDATA[Peptid-oligoDNA konjugat, DNAzim, fluorescencija, biooslikavanje, bioaktivnost, teranostika]]></keywords_hr><keywords_en><![CDATA[Peptide-oligoDNA conjugate, DNAzyme, fluorescence, bioimaging, bioactivity, theranostics]]></keywords_en><summary_hr><![CDATA[Male organske molekule čija struktura je kontrolirana vanjskim podražajima, na primjer fotokromne boje sposobne reverzibilno mijenjati strukturu pod svijetlom različitih valnih duljina, su u znanstvenom fokusu između ostalog i zbog njihove foto-kontrolirane biološke aktivnosti. S druge strane, konjugati proteina ili peptida s različitim oligoDNA (POC, eng. protein-oligoDNA conjugate) intenzivno se proučavaju zbog  primjena u biološkim istraživanjima molekularnog prepoznavanja, biooslikavanja, DNA nanotehnologije, razvoja dijagnostičkih testova i biosenzora. U prethodnom HrZZ projektu razvili smo multikromoforne peptide i nove fluorescentne boje, neke od njih kontrolirane foto-prekidačem, za različite bioaplikacije. U ovom prijedlogu želimo iskoristiti ranije razvijena znanja i materijal za dizajn, pripravu i karakterizaciju peptid-ALAT KONTOLE-kromofor sustava za biorelevantne ciljeve. Jedna linija je fokusirana na nove foto-kontrolirane peptid-multikromofor sustave koji ciljaju DNA, RNA, protein ili stanične organele; dok bi 2. linija bila bazirana na peptid-oligoDNA(POC)-fotoprekidač sustavima sa dodatnim svojstvom pojačanja signala pomoću DNAzima, koji ovisno o meti mijenja brzinu nastanka obojenog emzimskog produkta. Interakcije novopriređenih sustava s biorelevantnim metama (specifični slijed DNA, RNA, protein ili peptidni aggregat, stanice i/ili stanične organele) bi trebale izdvojiti najperspektivniije biosenzore ili teranostičke spojeve. Istraživanja financirana ovim projektom su na razini supramolekularne kemije, dok za provedbu bioloških eksperimenta na stanicama imamo podršku grupe s odgovarajućom opremom i certifikatima. Prijedlog je u skladu s ciljevima HrZZ-a: a) suradnja s međunarodno prepoznatim inozemnim znanstvenicima, b) osposobljavanje mladih istraživača u međunarodnom istraživačkom okruženju i c) potencijal komercijalizacije novih teranostičkih agensa. Predviđenih 1 487 777.78 HRK i tim od 7 istraživača osiguravaju izvedivost.]]></summary_hr><summary_en><![CDATA[Small organic molecules with structure controlled by external stimuli, e.g. photochromic dyes capable of reversibly changing their structure upon irradiation at different wavelength, are currently in the scientific focus because of their photo-controlled biological activity. On the other hand, conjugates of proteins or peptides with various oligoDNA (protein-oligoDNA conjugates, “POC”) are intensively studied due to applications in the research of molecular recognition, bioimaging, DNA nanotechnology, and development of diagnostic tests and biosensors. In the previous HrZZ project, we developed multichromophore peptides and new fluorescent dyes, some of them controlled by a photo-switch, for various bioapplications. In this proposal, we want to use previously developed knowledge and material for the design, preparation and characterization of the peptide-CONTROL TOOL-chromophore system for biorelevant targets. One researchline is focused on new photo-controlled peptide-multichromophore systems targeting various DNA, RNA, protein or cellular organelles; while the 2nd line would be based on peptide-oligoDNA(POC)-photoswitch systems with the additional feature of signal amplification by DNAzyme, by changes in the formation rate of the coloured enzyme product. Interactions of newly prepared systems with biorelevant targets (specific DNA, RNA, protein or peptide aggregate, cells and/or cell organelles) should single out the most promising biosensors or theranostic compounds. Research is at the level of supramolecular chemistry, while the biological experiments on cells are supported on our institute by team with appropriate equipment and certificates. In line with the HrZZ objectives proposal supports: a) cooperation with internationally recognized foreign scientists, b) training of young researchers in an international research environment and c) the potential for commercialization. The foreseen 197 462.05 EUR and a team of 7 researchers ensure feasibility.]]></summary_en></project><project>
<id>18117</id><title_hr><![CDATA[Inovativni pristupi za smanjenje nusproizvoda dezinfekcije voda - nove tehnologije za nove izazove]]></title_hr><title_en><![CDATA[]]></title_en><user_id>20206</user_id><user_firstLast_name>Krešimir Košutić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-8113</code><acronim><![CDATA[InWatTechno]]></acronim><duration>10.11.2025 - 09.11.2031</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Interdisciplinarne tehničke znanosti, </scie_field_hr><scie_field_en>Interdisciplinary technological sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet kemijskog inženjerstva i tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Chemical Engineering and Technology]]></institution_en><team_members_id>872904</team_members_id><team_members_names><![CDATA[ Doktorand: Ena Miletić ]]></team_members_names><keywords_hr><![CDATA[pitke vode, bazenske vode, dezinfekcijski nusproizvodi vode, membranski procesi, napredni oksidacijski procesi]]></keywords_hr><keywords_en><![CDATA[potable water, pool water, disinfection byproducts, membrane processes, advanced oxidation processes]]></keywords_en><summary_hr><![CDATA[InWatTechno projekt na inovativan način povezuje napredne membranske i oksidacijske postupke uklanjanja i razgradnje nusproizvoda dezinfekcije vode (DNP-a) i njihovih prekursora iz pitkih i bazenskih voda. Ciljani spojevi koji će se istraživati u ovom projektu su trihalometani (THM), halooctene kiseline (HAA) i nitrozamini (NA), od kojih je većina obuhvaćena europskim pa tako i hrvatskim propisima. Svi oni predstavljaju potencijalni rizik za zdravlje ljudi i vodni sustav. Povezivanje membranskih, posebno NF/RO procesa, s naprednim oksidacijskim procesima (AOP) kao što su O3/UV, H2O2/UV, O3/H2O2, UV/TiO2 i dr., predstavlja novije istraživačke trendove u obradi voda i njezine intenzifikacije s ciljem maksimalnog uklanjanja organskih mikroonečišćivala sintetskog porijekla (ksenobiotika) te DNP-a koji nastaju klasičnim postupcima dezinfekcije vode klorom i kloru sličnim dezinfekcijskim sredstvima. Projekt se bavi izazovom osiguravanja što kvalitetnije pitke vode te uvođenja novih tehnoloških postupaka obrade voda specifičnih kategorija. Nove spoznaje praktično će se primijeniti u obradi (kondicioniranju) voda u funkciji poboljšanja kvalitete vode za piće i rekreaciju, tj. zaštite zdravlja ljudi. Utjecaj rezultata na okoliš, tj. zaštitu vodnih resursa bit će vidljiv preko (a) smanjenja količine DNP-a u pitkim i bazenskim vodama koje nakon uporabe završavaju u okolišu kao otpadna voda i (b) smanjenja količine DNP-a u retentatu na izlazu iz membranskih procesa koji se također ispušta kao otpadna voda. Na taj način će se osigurati i zadovoljiti zakonska regulativa.]]></summary_hr><summary_en><![CDATA[The InWatTechno project innovatively combines advanced membrane and oxidation processes for removal and degradation of disinfection byproducts (DBPs) and their precursors (xenobiotics) from drinking and pool waters. The target compounds that will be investigated in this project are trihalomethanes (THM), haloacetic acids (HAA), and nitrosamines (NA), most of which are covered by European and Croatian regulations. All of them pose a potential risk to human health and the water system.Coupling advanced membrane, especially nanofiltration/reverse osmosis (NF/RO) processes, with advanced oxidation processes (AOP) such as O3/UV, H2O2/UV, O3/H2O2, UV/TiO2, etc., represents recent research trends in water treatment and its intensification with the aim of maximum removal of organic micropollutants of synthetic origin (xenobiotics), and DBPs that are produced by classic water disinfection procedures with chlorine and chlorine-like disinfectants. InWatTechno project deals with the challenge of ensuring high-quality drinking water and introducing new technological procedures for water treatment of specific categories. The new knowledge will be practically applied in the treatment (conditioning) of water in order to improve the quality of potable and pool water, i.e. the protection of human health. The impact of the results on the environment, i.e. the protection of water resources, will be visible through (a) a reduction in the amount of DBPs in drinking and swimming pool waters that end up in the environment as wastewater after use and (b) a reduction in the amount of DBPs in the retentate at the exit from of membrane unit, which is also discharged as wastewater. In this way, compliance with the legal regulations will be ensured.]]></summary_en></project><project>
<id>18118</id><title_hr><![CDATA[Istraživanje proizvodnje jezgara bogatih neutronima reakcijama prijenosa mnogo nukleona]]></title_hr><title_en><![CDATA[Exploring Neutron-Rich Isotope Production with Multinucleon Transfer Reactions]]></title_en><user_id>257</user_id><user_firstLast_name>Tea Mijatović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2025-02</proposal_call><code>UIP-2025-02-8168</code><acronim><![CDATA[ENRichMenT]]></acronim><duration>19.02.2026 - 18.02.2031</duration><status>U tijeku</status><financ_value>299.875,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>24834, 870402, 872926, </team_members_id><team_members_names><![CDATA[Lovro Palaversa, Mirco Del Fabbro, Laura Busak, ]]></team_members_names><keywords_hr><![CDATA[reakcije prijenosa mnogo nukleona, struktura jezgara, neutronski bogate jezgre, magnetski spektrometri, gamma spektrometri]]></keywords_hr><keywords_en><![CDATA[multinucleon transfer reactions, nuclear structure, neutron-rich nuclei, magnetic spectrometers, gamma-ray arrays]]></keywords_en><summary_hr><![CDATA[Predloženi projekt istražuje reakcije prijenosa mnogo nukleona kao alat za sintezu teških jezgara bogatih neutronima, posebno u blizini neutronskog magičnog broja 126 i u području aktinida. Korištenjem najsuvremenije instrumentacije i naprednih mogućnosti magnetskog spektrometra PRISMA, gamma spektrometra AGATA i detektora NOSE, provest ćemo visokorezolucijska mjerenja raspodjele mase (A), naboja (Z) i energije te detaljnu gama-spektroskopiju reakcijskih produkata. Primjenom inverzne kinematike i inovativnih tehnika trostruke koincidencije, cilj nam je po prvi put izravno detektirati oba reakcijska partnera s dosad neviđenom rezolucijom te kvantificirati utjecaj sekundarnih procesa, poput evaporacije neutrona i fisije, na njihovu vjerojatnost preživljavanja. Nadalje, u novom skupu eksperimenata istražit ćemo mogućnosti širog raspona kutova detekcije te po prvi put koristiti reakcelerirane radioaktivne snopove s magnetskim spektrometrom. Očekivani rezultati predloženog projekta uključuju visokokvalitetne eksperimentalne podatke iz nekoliko ključnih eksperimenata, koji će pružiti nove uvide u nuklearne reakcije i strukturu jezgara bogatih neutronima. Ti rezultati bit će predstavljeni na vodećim međunarodnim konferencijama i objavljeni u vrhunskim znanstvenim časopisima, pružajući vrijedne reference za teorijske modele. Osim znanstvenih doprinosa, predloženi projekt će uspostaviti novu istraživačku grupu za fiziku teških iona na Institutu Ruđer Bošković, s bogatim međunarodnim istraživačkim iskustvom. Time će se razviti sveobuhvatan pristup proučavanju mehanizama reakcija i strukture jezgara bogatih neutronima, koristeći najsuvremenije detekcijske sustave i tehnike. Ovo će značajno ojačati položaj Hrvatske u međunarodnoj istraživačkoj zajednici i postaviti temelje za dugoročnu izvrsnost u nuklearnoj fizici i srodnim područjima.]]></summary_hr><summary_en><![CDATA[The proposed project investigates multinucleon transfer reactions as a tool for synthesizing neutron-rich heavy nuclei, particularly near the neutron magic number 126 and in the actinide region. Utilizing state-of-the-art instrumentation and advanced capabilities of the PRISMA magnetic spectrometer, the AGATA gamma-ray tracking array, and the NOSE detector, we will conduct high-resolution measurements of mass (A), charge (Z), and energy distributions, and perform detailed gamma-ray spectroscopy of reaction products. By employing inverse kinematics and innovative triple coincidence techniques, we aim to directly detect both reaction partners for the first time with unprecedented resolution and quantify the effects of secondary processes such as neutron evaporation and fission on their survival probability. Additionally, in a new set of experiments we will explore a potential of using a broader range of detection angles and utilize reaccelerated radioactive beams for the first time with the magnetic spectrometer.The expected results of the proposed project are high-quality experimental data from several key experiments, providing new insights into nuclear reactions and structure of neutron-rich nuclei. These results will be presented at leading international conferences and published in top international journals, offering valuable benchmarks for theoretical models.  Beyond its scientific contributions, the proposed project will establish a new heavy-ion physics group at RBI with extensive international research experience, that will establish new comprehensive approach to the study of reaction mechanisms and structure of neutron-rich heavy nuclei with the most-modern detection systems and techniques. This will strengthen Croatia’s position in the international research community and establish a foundation for long-term excellence in nuclear physics and related fields. ]]></summary_en></project><project>
<id>18121</id><title_hr><![CDATA[Očuvanje genetskih resursa nizinskog brijesta (Ulmus minor Mill.) – temelj za reintrodukciju u šumske sastojine]]></title_hr><title_en><![CDATA[Conservation of Field Elm (Ulmus minor Mill.) Genetic Resources: A Foundation for Reintroduction into Forest Stands]]></title_en><user_id>17850</user_id><user_firstLast_name>Sanja Bogunović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2025-02</proposal_call><code>UIP-2025-02-2683</code><acronim><![CDATA[ElmForFuture]]></acronim><duration>05.12.2025 - 04.12.2030</duration><status>U tijeku</status><financ_value>195.800,00 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Šumarstvo, Interdisciplinarne biotehničke znanosti, </scie_field_hr><scie_field_en>Forestry, Interdisciplinary biotechnical sciences, </scie_field_en><institution_hr><![CDATA[Hrvatski šumarski institut]]></institution_hr><institution_en><![CDATA[Croatian Forest Research Institute]]></institution_en><team_members_id>861738, 855914, 865373, 868739, 19035, </team_members_id><team_members_names><![CDATA[Mia Marušić, Doroteja Bitunjac, Marko Bačurin, Ivana Sirovica, Miran Lanšćak, ]]></team_members_names><keywords_hr><![CDATA[očuvanje genofonda, nizinski brijest, holandska bolest brijesta, mikropropagacija, vitalitet]]></keywords_hr><keywords_en><![CDATA[conservation of gene pool, field elm, dutch elm disease, micropropagation, vitality]]></keywords_en><summary_hr><![CDATA[Nizinski brijest (Ulmus minor Mill.) plemenita je listača s izuzetnom ekološkom i ekonomskom vrijednošću za šume Republike Hrvatske, no trenutno je to i jedna od najugroženijih vrsta u šumskim ekosustavima. Njegov areal znatno se smanjio tijekom 20. stoljeća zbog holandske bolesti brijesta koju uzrokuju gljive roda Ophiostoma. Prva pandemija započela je 1920-ih, uzrokovana gljivom Ophiostoma ulmi, dok je druga, još razornija, uslijedila 1970-ih s pojavom Ophiostoma novo-ulmi, ostavljajući trajan utjecaj na šumske ekosustave diljem Europe. Danas su populacije nizinskog brijesta svedene na manje skupine i pojedinačna stabla, a njegovu ulogu potpore hrastu lužnjaku (Quercus robur L) u šumama postupno je preuzeo poljski jasen (Fraxinus angustifolia Vahl). Nakon masovnog odumiranja brijesta, poljski jasen desetljećima je s hrastom lužnjakom činio temelj nizinskih šumskih ekosustava. Međutim, posljednjih desetak godina bilježi se i pojačano sušenje poljskog jasena zbog različitih biotskih i abiotskih čimbenika. Zbog ugroženosti poljskog jasena i problema s hrastom lužnjakom, nizinski brijest ponovno dobiva na važnosti kao potencijalno rješenje za očuvanje nizinskih šuma. Njegovu obnovu potiče prisutnost vitalnih stabala koja nisu pokazala znakove zaraze holandskom bolešću te su, unatoč njenom širenju kroz cijeli areal nizinskog brijesta, preživjela do danas. Kroz ispunjenje ciljeva ovog projekta oformiti će se istraživački tim koji će multidisciplinarnim pristupom raditi na očuvanju genofonda ove vrijedne vrste. Očuvanje genofonda i istraživanje poveznice između stanišnih uvjeta i vitaliteta su prvi koraci u istraživanju otpornosti nizinskog brijesta na holandsku bolest. Kroz ovo istraživanje postaviti će se temelji za daljnja istraživanja otpornosti nizinskog brijesta na biotski i abiotski stres te izraditi preporuke za njegovu reintrodukciju u šumske sastojine.]]></summary_hr><summary_en><![CDATA[Field elm (Ulmus minor Mill.) is a deciduous tree species with exceptional ecological and economic value for the Republic of Croatia. However, it is currently one of the most endangered species in forest ecosystems. Its range significantly declined during the 20th century due to Dutch Elm Disease, caused by fungi of the genus Ophiostoma. The first pandemic began in the 1920s, driven by Ophiostoma ulmi, while the second, even more severe outbreak occurred in the 1970s with the emergence of Ophiostoma novo-ulmi, leaving a lasting impact on forest ecosystems across Europe. Lowland elm populations have been reduced to small groups and individual trees. Its previous role in supporting pedunculate oak (Quercus robur L.) in forests has gradually been taken over by narrow-leaved ash (Fraxinus angustifolia Vahl.). Following the massive die-off of field elm, narrow-leaved ash, alongside pedunculate oak, became the foundation of lowland forest ecosystems for decades. However, in the past decade, increasing dieback of narrow-leaved ash has been observed due to various biotic and abiotic factors. Given the growing vulnerability of narrow-leaved ash and the challenges affecting pedunculate oak, field elm is regaining importance as a potential solution for preserving lowland forests. Its recovery is supported by the presence of vital trees that have shown no signs of Dutch Elm Disease, surviving despite the pathogen&#39;s spread across the species&#39; entire range. A research team will be formed within this project to conserve the genetic resources of this valuable species through a multidisciplinary approach. The first steps will include conserving its genetic diversity and investigating the relationship between stand conditions and tree vitality. These findings will serve as a foundation for future studies on the lowland elm&#39;s resistance to biotic and abiotic stress, ultimately guiding recommendations for its reintroduction into forest stands.]]></summary_en></project><project>
<id>18124</id><title_hr><![CDATA[Primjena metanola za postizanje niskougljičnog pomorskog ribarstva]]></title_hr><title_en><![CDATA[Application of methanol to achieve a low-carbon marine fishing]]></title_en><user_id>13468</user_id><user_firstLast_name>Momir Sjerić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-4970</code><acronim><![CDATA[GREEN-MAR]]></acronim><duration>30.12.2025 - 29.12.2028</duration><status>U tijeku</status><financ_value>148.465,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, Brodogradnja, Zrakoplovstvo, raketna i svemirska tehnika, </scie_field_hr><scie_field_en>Mechnical engineering, Naval architecture, Aerospace, missile and space engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>252, 865297, 868362, 13456, 11160, </team_members_id><team_members_names><![CDATA[Nikola Vladimir, Sara Ugrinić, Marija Koričan, Ante Vučetić, Darko Kozarac, ]]></team_members_names><keywords_hr><![CDATA[metanol, dvogorivno izgaranje, održivost, dekarbonizacija, pomorsko ribarstvo]]></keywords_hr><keywords_en><![CDATA[methanol, dual fuel combustion, sustainability, decarbonization, marine fishing]]></keywords_en><summary_hr><![CDATA[Suočeni sa sve izraženijim posljedicama globalnog onečišćenja i zatopljenja, nameće se potreba za primjenom tehnoloških rješenja koja će u što većoj mjeri smanjiti negativni utjecaj motora s unutarnjim izgaranjem na okoliš. Zbog brojnih prednosti u usporedbi s ostalim alternativnim gorivima, metanol se pokazuje kao gorivo s najvećim potencijalom za dekarbonizaciju brodova. Može se proizvesti iz zelenog vodika i sustava prikupljanja ugljikovog dioksida (engl. Carbon Capturing System) iz atmosfere čime se značajno doprinosi smanjenju ugljičnog otiska. Jedno od najjednostavnijih i najjeftinijih rješenja za primjenu metanola u brodskim pogonskim sustavima je primjena niskotlačnog ubrizgavanja u usisnu cijev i ostvarivanje dvogorivnog izgaranja (engl. dual-fuel combustion). Primjenom prijenosnih analizatora za mjerenje emisija ispušnih tvari (CO2, CO, NOx, THC, PN i O2) stvoriti će se baza podataka o emisijama u uvjetima stvarne eksploatacije ribarskog broda. Provedbom eksperimentalnih ispitivanja na jednocilindarskom motoru uz primjenu dvogorivnog izgaranja metanola i dizelskog goriva, te primjenom numeričkih simulacija istražit će se potencijal primjene i kvantificirati svrha uvođenja metanola u Dieselovim motorima. Primjenom prednabijanja i povrata ispušnih plinova u dvogorivnom izgaranju istražiti će se mogućnost smanjenja ugljičnog otiska, dušikovih oksida te čestica čađe u radnim točkama motora koje odgovaraju pogonu ribarskog broda. Nakon validacije simulacijskog modela za dvogorivno izgaranje izraditi će se simulacija pogonskog motora ribarskog broda te će se analizirati značajke rada i emisije ispušnih tvari za njegov operativni ciklus. Rezultati projekta doprinesti će boljem razumijevanju i svrsi primjene efikasnijeg i ekološki prihvatljivijeg izgaranja metanola u pogonu brodova te će se ostvariti dodatni iskorak u primjeni tehnološkog rješenja koje osigurava klimatski neutralnu budućnost u ribarstvu.]]></summary_hr><summary_en><![CDATA[With the increasing consequences of global pollution and warming, there is a need to apply technological solutions that will minimize the negative environmental impact of internal combustion engines. Due to the numerous advantages compared to other alternative fuels, methanol is proven to be the fuel with the highest potential for decarbonizing ships. It can be produced from green hydrogen and a Carbon Capturing System from the atmosphere, which significantly contributes to reducing the carbon footprint. One of the simplest and cheapest solutions for using methanol in ship propulsion systems is the application of low-pressure injection into the intake manifold and the implementation of dual-fuel combustion. By using portable analyzers to measure exhaust emissions (CO2, CO, NOx, THC, PN and O2), a database of emissions under actual fishing vessel operation conditions will be created. By conducting experimental tests on a single-cylinder engine using dual-fuel combustion of methanol and diesel fuel, and by applying numerical simulations, the potential for application and quantification of the purpose of introducing methanol in Diesel engines will be investigated. By applying boosting and EGR in dual-fuel combustion, the possibility of reducing the carbon footprint, nitrogen oxides and soot particles in engine operating points that correspond to the propulsion of a fishing vessel will be investigated. After validating the simulation model for dual-fuel combustion, a simulation of the propulsion engine of a fishing vessel will be made and the operating characteristics and exhaust emissions for its operating cycle will be analyzed. The results of the project will contribute to a better understanding and purpose of applying more efficient and environmentally friendly methanol combustion in ship propulsion, and an additional step will be made in the application of a technological solution that ensures a climate-neutral future in fishing.]]></summary_en></project><project>
<id>18125</id><title_hr><![CDATA[Učinak okolišnih čimbenika i zagađenja na razvoj alergija na hranu u djece]]></title_hr><title_en><![CDATA[The effect of environmental pollution on the development of food allergies in children]]></title_en><user_id>5603</user_id><user_firstLast_name>Mirjana Turkalj</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-9052</code><acronim><![CDATA[Poll-FoodAll]]></acronim><duration>19.01.2026 - 18.01.2029</duration><status>U tijeku</status><financ_value>199.183,00 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Kliničke medicinske znanosti, Temeljne medicinske znanosti, Javno zdravstvo i zdravstvena zaštita, </scie_field_hr><scie_field_en>Clinical sciences, Basic Medical Sciences, Public health and health services, </scie_field_en><institution_hr><![CDATA[Hrvatsko katoličko sveučilište, Zagreb]]></institution_hr><institution_en><![CDATA[Catholic University of Croatia]]></institution_en><team_members_id>870444, 4231, 6890, 27244, 4282, 7199, 7639, 870434, </team_members_id><team_members_names><![CDATA[Mate Car, Roberto Antolović, Damir Erceg, Adnan Custovic, Ivana Banić, Adrijana Miletić Gospić, Marcel Lipej, Jan Pantlik, ]]></team_members_names><keywords_hr><![CDATA[okoliš, onečišćenje, mikroplastika, alergija na hranu, djeca]]></keywords_hr><keywords_en><![CDATA[environment, pollution, microplastics, food allergies, children]]></keywords_en><summary_hr><![CDATA[Prevalencija se alergijskih bolesti, a osobito alergija na hranu u djece  posljednjih se nekoliko desetljeća povećala za više od 150%, što je posljedica složenih interakcija između genske predispozicije i okolišnih čimbenika, poput izloženosti sveprisutnoj mikro- i nanoplastici (MNP) i onečišćenja zraka. MNP je već pronađena u  skoro većini ljudskih tkiva i tekućina. Putevi izloženosti MNP uključuju ingestiju, inhalaciju i dermalni kontakt. Novija in vitro istraživanja na modelnim organizmima ukazuju na to da čestice MNP, kao i na njih vezani biotički i abiotički agensi mogu imati niz štetnih zdravstvenih učinaka, no stvarna uloga navedenih polutanata u patofiziologiji alergija još uvijek nije poznata. Najvjerojatnije ti onečišćivači djeluju sinergistički i kumulativno (dugotrajna izloženost), a skupine kao što su djeca i kronični bolesnici, osobito su ranjive. Cilj ovog projekta je istražiti potencijalni toksični i imunomodulatorni učinak izloženosti različitim onečišćivačima (uključujući MNP) kroz utjecaj na integritet epitelne barijere, bioraznolikost crijevnog mikrobioma i upalni alergijski odgovor (tzv. propusna crijeva). U istraživanju bi se koristili dosad prikupljeni podaci i uzorci iz H2020 (IMPTOX i EDIAQI) projekata. Dodatno bi se u projektu uključilo do 100 djece s alergijama na hranu i drugim alergijskim bolestima, čija bi se izloženost polutantima iz zraka i MNP longitudinalno pratila, te bi se u biološkim uzorcima (stolica, krv, urin) detektirala prisutnost MNP i procjenjivao učinak na upalni alergijski odgovor i promjene u broju i sastavu crijevnog mikrobioma. Ovaj projekt ima za svrhu implementirati multisciplinarni istraživački pristup u generiranju novih znanja i spoznaja u patofiziologiji alergija i specifičnih podtipova bolesti i interakciji s novim okolišnim čimbenicima, koji će posljedično dovesti do poboljšanja dijagnostičkih i terapijskih režima te razvoja novih terapija u liječenju alergija na hranu i drugih alergijskih bolesti u djece.]]></summary_hr><summary_en><![CDATA[The prevalence of allergic diseases, especially food allergies in children, has increased in the last few decades by more than 150%. That is an effect of complex interactions between genetic predisposition and environmental factors, such as exposure to micro- and nanoplastics (MNP) and air pollution. MNP has been found so far in most human tissues and fluids. Routes of exposure to MNP include ingestion, inhalation and dermal contact. Recent in vitro studies on model organisms indicate that MNP particles, as well as biotic and abiotic agents bound to them, can have a number of adverse health effects, but the actual role of these pollutants in the pathophysiology of allergies is still unknown. Most likely these pollutants act synergistically and cumulatively, with children and chronically ill being particularly vulnerable. The aim of this project is to investigate the potential toxic and immunomodulatory effects of exposure to various pollutants (including MNPs) through their impact on epithelial barrier integrity, gut microbiome biodiversity and inflammatory allergic response (a.k.a. leaky gut). The research would use data and samples collected so far from the H2020 (IMPTOX and EDIAQI) projects. Project will additionally include up to 100 children with food allergies and other allergic diseases, whose exposure to air pollutants and MNPs would be longitudinally monitored, presence of MNPs would be detected in biological samples (stool, blood, urine) and the effect on the inflammatory allergic response and changes in the number and composition of the gut microbiome would be assessed. This project aims to implement a multidisciplinary research to generate new knowledge and insights into the pathophysiology of allergies and specific subtypes of the disease and their interaction with new environmental factors, which will consequently lead to improved diagnostic and development of new therapies in the treatment of food allergies and other allergic diseases in children.]]></summary_en></project><project>
<id>18131</id><title_hr><![CDATA[Procjena dostupnosti vode u mediteranskim šumama crnog bora]]></title_hr><title_en><![CDATA[Assessment of water availability in Mediterranean black pine forests]]></title_en><user_id>3501</user_id><user_firstLast_name>Lukrecija Butorac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-4184</code><acronim><![CDATA[ PINE-WATER ]]></acronim><duration>30.12.2025 - 29.12.2028</duration><status>U tijeku</status><financ_value>192.500,00 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Šumarstvo, Interdisciplinarne biotehničke znanosti, </scie_field_hr><scie_field_en>Forestry, Interdisciplinary biotechnical sciences, </scie_field_en><institution_hr><![CDATA[Institut za jadranske kulture i melioraciju krša]]></institution_hr><institution_en><![CDATA[Institute for Adriatic Crops and Karst Reclamation in Split]]></institution_en><team_members_id>5844, 870531, 849, 848, 3507, 25878, </team_members_id><team_members_names><![CDATA[Tamara Marković, Marco Lehmann, Ivan Seletković, Nenad Potočić, Goran  Jelić, Ivan Limić, ]]></team_members_names><keywords_hr><![CDATA[Mediteranska klima, varijabilnost oborina, stabilni izotopi (?18O, ?2H), tok hranjivih tvari i iona, biogeokemijski ciklus]]></keywords_hr><keywords_en><![CDATA[Mediterranean climate, Precipitation variability, Stable isotopes (?18O, ?2H)&#39;&#39;, Nutrient and ion fluxes, Biogeochemical cycling ]]></keywords_en><summary_hr><![CDATA[Mediteranske šume crnog bora (Pinus nigra J. F. Arnold) imaju ključnu ulogu u održavanju ekološke ravnoteže, osobito u regijama s izraženom sezonalnošću i ograničenim vodnim resursima. Dinamika kruženja vode i hranjivih tvari u ovim ekosustavima ovisi o složenim interakcijama između biljnog pokrova, tla, oborina i klimatskih čimbenika. Dublje razumijevanje tih procesa ključno je za održivo upravljanje šumskim ekosustavima, posebice u kontekstu klimatskih promjena.Ovaj projekt usmjeren je na procjenu dostupnosti vode u šumama crnog bora te analizu njene varijabilnosti u odnosu na sezonalnost, nadmorsku visinu i strukturne karakteristike šumskog sklopa. Cilj je utvrditi kako vegetacija i nadmorska visina utječu na izotopni sastav vode (?18O i ?2H) te identificirati izvore vode koje koriste stabla crnog bora. Specifični ciljevi su: istražiti izotopski sastav (?18O i ?2H) „izvora vode“ u odnosu na nadmorsku visinu i šumsku vegetaciju, odrediti vremensko podrijetlo „izvora vode“ koje koriste stabla crnog bora, procijeniti učinak šuma crnog bora na biogeokemijsko kruženje iona, uzimajući u utjecaj nadmorske visine i mikroklimatske uvjete te rocijeniti utjecaj atmosferskog taloženja na nutrijente u iglicama crnog bora. Rezultati ovog istraživanja doprinijet će boljem razumijevanju hidroloških i biogeokemijskih procesa u šumskim ekosustavima crnog bora te osigurati znanstveno utemeljene smjernice za njihovo održivo upravljanje.]]></summary_hr><summary_en><![CDATA[Mediterranean black pine (Pinus nigra J. F. Arnold) forests play a crucial role in maintaining ecological balance, particularly in regions with pronounced seasonality and limited water resources. Hydrological and biogeochemical cycles in these ecosystems depend on complex interactions between vegetation cover, soil, precipitation, and climatic factors. A deeper understanding of these processes is essential for the sustainable management of forest ecosystems, especially in the context of climate change.This project assesses water availability in black pine forests and analyzes its variability in relation to seasonality, elevation, and forest structural characteristics. The objective is to determine how vegetation and elevation influence the isotopic composition of water (?18O and ?2H) and to identify the water sources used by black pine trees. The main research goals are: to examine the isotopic composition (?18O and ?2H) of water sources in relation to elevation and forest vegetation, to determine the temporal origin of the water sources utilized by black pine trees, to evaluate the impact of black pine forests on the biogeochemical cycling of ions, considering altitude and microclimatic conditions, o analyze the effect of atmospheric deposition on the nutrient composition of black pine needles.The findings of this study will enhance our understanding of hydrological and biogeochemical processes in black pine forest ecosystems and provide scientifically grounded guidelines for their sustainable management.]]></summary_en></project><project>
<id>18139</id><title_hr><![CDATA[Regionalna diferencijacija i laminarni ustroj moždane kore čovjeka: inovativni komparativni pristup]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5534</user_id><user_firstLast_name>Zeljka Krsnik</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-4589</code><acronim><![CDATA[ReDyNovApp]]></acronim><duration>11.11.2025 - 10.11.2031</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>872995</team_members_id><team_members_names><![CDATA[ Doktorand: Gracia Grabaric ]]></team_members_names><keywords_hr><![CDATA[moždana kora čovjeka, čeona moždana kora, regionalizacija, laminacija, projekcijski neuroni dubokih slojeva korteksa, Tbr1, SOX5]]></keywords_hr><keywords_en><![CDATA[human cerebral cortex, frontal cortex, regionalization, lamination, deep-layers projecting neurons, Tbr1, SOX5]]></keywords_en><summary_hr><![CDATA[Moždana kora čovjeka kao sjedište viših spoznajnih funkcija podjeljena je u strukturno-funkcionalno definirana Brodmannova polja (area). Tijekom ranog prenatalnog razdoblja  najprije dolazi do  podjele moždane kore na regije, prije samog procesa arealizacije. Unatoč impresivnim novim saznanjima u području razvojne neurobiologije, ostaju brojna otvorena pitanja o razvoju ljudske moždane kore, uključujući i fundamentalno pitanje: kada i kako se javljaju prve regionalne razlike moždane kore na molekularnom, staničnom i laminarnom nivou?Stoga smo okupili sljedeće istraživačke resurse i ekspertize: Krsnik (Medicinski fakultet u Zagrebu)– razvoj moždane kore čovjeka; Duque (Yale/MacBrain Resource)- komparativna analiza moždane kore Macaca mulatta; Haldipur (Seattle Children’s Research Institute)- spatial transcriptomics; Menassa (Oxford)-analiza podataka, te Alić (Fakultet Veterinarske medicine)–organoidni model. Testirat ćemo sljedeću hipotezu: ekspresija markera projekcijskih neurona dubokih slojeva moždane kore (DPN) pokazuje regionalne razlike već tijekom ranog fetalnog razvoja, dok se konačni obrasci kortikalnih tipova uspostavljaju tijekom faze formiranja subplate-a.Naši preliminarni rezultati pokazuju da markeri DPN čeone moždane kore pokazuju ranu regionalnu diferencijaciju korteksa (sa 7.5 tjedana nakon začeća). Međutim, najupečatljivija regionalna diferencijacija u čeonom režnju prisutna je u fazi oblikovanja subplate-a u orbitofrontalnom korteksu. Nadalje, laminarna dinamika DPN, zajedno s veličinom subventrikularne zone i načinom oblikovanja subplate zone je nedvojbeni rani pokazatelj regionalne diferencijacije cingularne moždane kore, čak nekoliko mjeseci prije uspostave Brodmannovih area. Stoga, primjenom komparativnog pristupa (čovjek/rezus) i inovativnih tehnologija (&#39;&#39;spatial transcriptomics&#39;&#39;, organoidni model), cilj nam je odgovoriti na fundamentalno pitanje kortikogeneze: kada i kako nastaje rana regionalna diferencijacija moždane kore čovjeka. ]]></summary_hr><summary_en><![CDATA[The human cerebral cortex, a seat of processing higher level cognitive functions, is subdivided into structurally and functionally defined Brodmann areas. The early prenatal regional patterning of cerebral cortex precedes arealization. Despite recent impressive advances in developmental neurobiology, numerous questions remain open, including: how and when regional cortical differences appear at the laminar, cellular and molecular level.To address this question, research team will combine the following expertise/resources: Krsnik (Medical School Zagreb)–human cortical development; Duque (Yale/MacBrain Resource)-comparative Rhesus macaque cortical development; Haldipur (Seattle Children&#39;s Institute)-spatial transcriptomics; Menassa (Oxford)-data analysis and Alić (Faculty of Veterinary medicine, Zagreb)–organoid model.Our team will test following hypothesis: deep-layers projection neurons (DPN) markers show cortex-type specific regional differentiation during early fetal period, but the final pattern of differences between cortical types is established during the subplate formation.In a preliminary study, DPN markers, a pivotal players during corticogenesis,  showed surprisingly early regional differentiation of human associative frontal cortex (already at 7.5 postconceptional weeks, PCW). The most prominent regional patterning in the frontal lobe was seen during the subplate formation phase, as a unique feature of orbitobasal frontal cortex. Additionally, the laminar dynamics of DPN markers, along with the subventricular zone size and the mode of subplate formation, clearly indicate regional differentiation of cingulate cortex several months before arealization. Therefore, implementing a comparative (human/rhesus macaque) approach and advanced techniques (spatial transcriptomics, organoid model), we aim to answer a fundamental question concerning early regional differentiation of the human cerebral cortex.]]></summary_en></project><project>
<id>18140</id><title_hr><![CDATA[Umjetna inteligencija, autonomija i pravednost]]></title_hr><title_en><![CDATA[]]></title_en><user_id>29263</user_id><user_firstLast_name>Tomislav Bracanović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-3003</code><acronim><![CDATA[AIAJ]]></acronim><duration>01.12.2025 - 30.01.2030</duration><status>U tijeku</status><financ_value>60,00 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filozofija, </scie_field_hr><scie_field_en>Philosophy, </scie_field_en><institution_hr><![CDATA[Institut za filozofiju]]></institution_hr><institution_en><![CDATA[Institute for Philosophy in Zagreb]]></institution_en><team_members_id>872999</team_members_id><team_members_names><![CDATA[ Doktorand: Helena Drmić ]]></team_members_names><keywords_hr><![CDATA[Umjetna inteligencija, etika, politička filozofija, autonomija, pravednost]]></keywords_hr><keywords_en><![CDATA[Artificial intelligence, ethics, political philosophy, autonomy, justice]]></keywords_en><summary_hr><![CDATA[Projektni prijedlog posvećen je istraživanju moralnih i političkih implikacija umjetne inteligencije (UI) za vrijednosti autonomije i pravednosti na individualnoj, društvenoj i političkoj razini ljudskog života. U središtu prijedloga je UI usmjerena na praktična tehnološka rješenja koja ima sve šire primjene u raznim vrstama poslovanja, informiranju, komunikaciji, prometu, funkcioniranju javnih i socijalnih službi, svakodnevnom životu, zabavi i osobnim odnosima. Projekt će ispitati normativne izazove koje takvo širenje UI donosi, usredotočujući se na autonomiju i pravednost kao međusobno povezane pojmove etike i političke filozofije. Projekt ima pet ciljeva: istražiti u kojoj su mjeri koncepcije autonomije i pravednosti iz relevantnih teorija etike i političke filozofije oblikovale raspravu o autonomnim vozilima i u kojim smjerovima bi se ta rasprava mogla dalje razvijati; istražiti normativne prijepore povezane s autonomnim naoružanim sustavima, implikacije koje njihova upotreba ima za vrijednosti autonomije i pravednosti te njihovu uklopivost u okvire teorije pravednog rata; istražiti socioekonomske posljedice uvođenja UI u različite poslovne procese, iz perspektive socijalne i distributivne pravednosti i perspektive autonomije različitih dionika tog procesa; istražiti kako sustavi UI generiraju napetost u socijalnim i pravnim kontekstima i koliko je ta napetost, s obzirom na vrijednosti autonomije i pravednosti, specifična u usporedbi s drugim primjenama UI; istražiti narav ljudske nesklonosti sustavima UI i opravdanost behavioralnih utjecaja, neurokemijskih poboljšanja ili umjetne inteligencije za postizanje optimalnog odnosa između njihove učinkovitosti, ljudske autonomije i pravednosti. Projektni prijedlog pristupa autonomiji i pravednosti u njihovoj  povezanosti i istražuje njihov dinamičan odnos kroz različita područja i kontekste primjene UI.]]></summary_hr><summary_en><![CDATA[The project proposal is dedicated to the research of moral and political implications of artificial intelligence (AI) for the values of autonomy and justice at individual, social and political levels of human life. At the heart of the proposal is AI focused on practical technological solutions that have wide applications in various types of business, information, communication, traffic, functioning of public and social services, everyday life, entertainment and personal relationships. The project will examine normative challenges of such a proliferation of AI, focusing on autonomy and justice as interrelated concepts of ethics and political philosophy. The project has five objectives: to investigate to what extent conceptions of autonomy and justice from relevant theories of ethics and political philosophy have shaped the debate on autonomous vehicles and in what directions this debate could develop further; to investigate the normative controversies associated with autonomous weapons systems, the implications their use has for the values of autonomy and justice, and their fit into the framework of just war theory; to investigate the socioeconomic consequences of the introduction of AI into various business processes, from the perspective of social and distributive justice and the perspective of the autonomy of the various stakeholders of that process; to investigate how AI systems generate tension in social and legal contexts and how specific this tension is, with respect to the values of autonomy and justice, compared to other applications of AI; to investigate the nature of human aversion to AI systems and the justifiability of using behavioral influencing, neurochemical enhancement or AI to achieve an optimal relationship between their effectiveness, human autonomy and justice. Project proposal approaches autonomy and justice in their interconnectedness and explores their dynamic relationship across different areas and contexts of the application of AI.]]></summary_en></project><project>
<id>18141</id><title_hr><![CDATA[Napredni modeli dinamičkih energijskih budžeta s transportnom mrežom]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5520</user_id><user_firstLast_name>Tin Klanjšček</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-6713</code><acronim><![CDATA[AdvanDEB]]></acronim><duration>21.01.2026 - 20.01.2031</duration><status>U tijeku</status><financ_value>60,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Interdisciplinarne prirodne znanosti, </scie_field_hr><scie_field_en>Interdisciplinary natural sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>873014</team_members_id><team_members_names><![CDATA[ Doktorand: Ivana Terzić ]]></team_members_names><keywords_hr><![CDATA[bioenergetika, Dinamički Energijski Budžeti (DEB), ekotoksikologija, fiziološko modeliranje, Umjetne neuronske mreže ]]></keywords_hr><keywords_en><![CDATA[bioenergetics, Dynamic Energy Budgets (DEB), ecotoxicology, mechanistic physiological modeling, artificial neural networks (ANN)]]></keywords_en><summary_hr><![CDATA[Modeli dinamičkih energijskih budžeta (DEB) kvantitativni su alat koji opisuje akviziciju i alokaciju energije u organizmima, te tako omogućuju povezivanje više okolišnih i bioloških razina. Stoga su često bili ključni u rješavanju važnih društvenih problema od proizvodnje hrane, zaštite biodiverziteta i ekosustava, korištenja resursa, do učinaka zagađivala na organizme. Moderni DEB modeli preuzetu energiju trenutačno pohranjuju u rezerve, koju pomoću &#39;&#39;k-pravila&#39;&#39; raspodjeljuje u stalnom omjeru reprodukciji i drugim procesima. Takvi DEB modeli dobro simuliraju učinke dugoročnih procesa ali nisu adekvatni za modeliranje kratkoročnih, te ne povezuju vjerodostojno varijable stanja s fiziologijom organizama. Uključivanjem transportne mreže kao što je krvotok u model mogu se otkloniti ti nedostaci. Iako je uspješnom primjenom transportne mreže na kita i indikacija da je primjenjiva na ribe pokazala visok potencijal široke njihove primjene, preostala su mnoga neriješena pitanja koja onemogućavaju široku primjenu i prihvaćanje DEB modela temeljenih na transportnim mrežama (tDEB). Projekt AdvanDEB dat će odgovore na ta ključna pitanja (i) provjerom i osiguranjem dosljednosti s poznatim biološkim principima, (ii) definiranjem jasnih pravila za korištenje energije tijekom reprodukcije, (iii) testiranjem općenitosti i definiranjem primjenjivosti tDEB-a, (iv) analizom odnosa između tDEB-a i drugih teorija i (v) razvijanjem formalnog skupa pretpostavki i jedinstvene terminologije.AdvanDEB će iskoristiti postojeće resurse kao što je AmP baza podataka DEB zajednice od 4500 vrsta, te konvencionalnim metodama i metodama potpomognutima umjetnom inteligencijom identificirati domene primjenjivosti za tDEB, istražiti općenitosti unutar i između filogenetskih skupina, te formalizirati tDEB teoriju. Dodatno, AdvanDEB može ujediniti DEB teoriju s Metaboličkom teorijom ekologije, čime stvara potencijal za promjenu paradigme u bioenergetici i otvara nove puteve istraživanja.]]></summary_hr><summary_en><![CDATA[Dynamic Energy Budget (DEB) models describe acquisition and utilization of energy in organisms, and have been instrumental in connecting scales of biological integration to solve a number of existing and emerging societal issues such as optimizing food production, improving conservation, optimizing resource use, and understanding effects of pollutants. Currently, DEB models assume acquired energy is immediately stored in the organism, and utilize the kappa-rule to partition energy between reproduction and other processes. The k-rule DEB (kDEB) models excel at capturing long-term effects, but struggle with short-term changes and linking to organism physiology.Integration of a transport network, such as blood, holds promise for overcoming these limitations. A study on marine mammals and an initial study on fish model that incorporates such a network suggest these transport-based DEB models could be widely applicable. While these models hold promise, key challenges to their wide adoption need to be addressed.AdvanDEB project tackles these key challenges: (i) ensuring consistency with established biological principles, (ii) defining clear rules for energy use during reproduction, (iii) testing generality and defining applicability of tDEB, (iv) analyzing relationships between tDEB and other theories, and (v) developing a formal set of assumptions and a unified terminology. AdvanDEB will leverage existing resources like the DEB community&#39;s AmP database of 4500 species, conventional analysis, and artificial-neural-network approaches to identify domain of applicability for tDEB, investigate within- and between-phylum generality, and formalize the tDEB theory. Additionally, AdvanDEB may unify DEB theory with the Metabolic Theory of Ecology, thus potentially inducing a paradigm shift in bioenergetics, and opening new avenues of research.]]></summary_en></project><project>
<id>18142</id><title_hr><![CDATA[Analiza diferencijalnih i pseudodiferencijalnih problema mješovitog tipa]]></title_hr><title_en><![CDATA[Analysis of differential and pseudodifferential problems of mixed type]]></title_en><user_id>72</user_id><user_firstLast_name>Marko Erceg</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2025-02</proposal_call><code>UIP-2025-02-1337</code><acronim><![CDATA[APsiDoM]]></acronim><duration>19.02.2026 - 18.02.2031</duration><status>U tijeku</status><financ_value>297.338,75 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>25426, 867942, 23449, </team_members_id><team_members_names><![CDATA[Matko Grbac, Tomislav Perić, Ivana Vojnović, ]]></team_members_names><keywords_hr><![CDATA[degenerirane paraboličke j., brzinsko usrednjenje, Friedrichsovi sus., pseudodiferencijalni op., zadaće mješovitog tipa, mikrolokalni defektni alati]]></keywords_hr><keywords_en><![CDATA[degenerate parabolic equations, velocity averaging, Friedrichs systems, pseudodifferential operators, problems of mixed type, microlocal defect tools]]></keywords_en><summary_hr><![CDATA[Parcijalne diferencijalne jednadžbe se javljaju kao matematički modeli mnogih pojava koje su vezane uz gotovo sve znanosti: fiziku, biologiju, geoznanosti, itd. Za njihovu analizu je važna klasifikacija po tipu, pa prepoznajemo na primjer hiperboličke, paraboličke i eliptičke jednadžbe. Budući da diferencijalni operatori nisu zatvoreni s obzirom na osnovne operacije (npr. inverz eliptičkog diferencijalnog operatora općenito nije diferencijalni operator), korisno je analizu proširiti unutar šire klase pseudodiferencijalnih operatora, pri čemu su bitna svojstva, pa i tip, sadržana u simbolu. Međutim, neke važne primjene uključuju jednadžbe (odnosno simbole) mješovitog tipa, poput toka s prijelazom s podzvučne na nadzvučnu brzinu. Zbog izmiješanosti suprotnih svojstava različitih tipova u jednu jednadžbu, ove jednadžbe su vrlo zahtjevne za proučavanje. U ovom projektu ćemo se posvetiti dvama povijesno prepoznatim okvirima za njihovo proučavanje: kinetičkoj formulaciji degeneriranih paraboličkih jednadžbi drugog reda i Friedrichsovim sustavima, s ciljem dobivanja novih rezultata o temeljnim pitanjima: dobroj postavljenosti, regularnosti, ponašanju na rubovima domene. Preciznije, u teoriji fizikalno relevantnog pojma entropijskih rješenja degeneriranih paraboličkih jednadžbi, jednadžba dopušta kinetičku formulaciju kojom se dobiva linearna diferencijalna jednadžba, ali sa singularnom desnom stranom. Ovaj oblik je pogodan za primjenu brzinskog usrednjenja, kao i raznih alata mikrolokalne i harmonijske analize. S druge strane, Friedrichsovi sustavi su zanimljivi za proučavanje jer obuhvaćaju mnoge linearne parcijalne diferencijalne jednadžbe neovisno o tipu, dok je način na koji se zadaju (početni i) rubni uvjeti prikladan i za jednadžbe mješovitog tipa. Mnoge numeričke metode i analitički rezultati su se razvili posljednjih godina, ali sustavniji povratak na izvornu motivaciju njihovog uvođenja, proučavanje jednadžbi mješovitog tipa, je izostao.]]></summary_hr><summary_en><![CDATA[Partial differential equations (PDEs) arise as mathematical models for a wide range of phenomena across various scientific disciplines, such as physics, biology, geoscience, etc. The classification by type (e.g. hyperbolic, parabolic, elliptic) is important for their analysis. Since differential operators are not closed with respect to basic operations (e.g. the inverse of an elliptic differential operator is generally not a differential operator), it is useful to extend the analysis within the broader class of pseudodifferential operators, where essential properties, including the type, are contained in the symbol. However, some significant applications involve equations (or symbols) of mixed type, such as flows transitioning from subsonic to supersonic speeds. Due to the combination of opposing properties of different types into a single equation, the study of these equations is highly demanding. In this project, our focus will be on two historically recognised frameworks for their study: the kinetic formulation of degenerate second-order parabolic equations and Friedrichs systems, with the aim of obtaining new results on fundamental questions: well-posedness, regularity, behaviour at the boundary. More precisely, in the theory of physically relevant concept of entropy solutions of degenerate parabolic equations, the equation allows a kinetic formulation resulting in a linear PDE, albeit with a singular right-hand side. This form is amenable for application of velocity averaging, as well as various tools of microlocal and harmonic analysis. On the other hand, Friedrichs systems are interesting to study as they encompass many linear PDEs regardless of type, and the method for imposing (initial and) boundary conditions is suitable even for equations of mixed type. While numerous numerical methods and analytical results have emerged, a more systematic return to the original motivation for their introduction, the study of mixed-type equations, is lacking.]]></summary_en></project><project>
<id>18150</id><title_hr><![CDATA[Supramolekulska asimetrična kataliza: Prijenos kiralnosti u koordinacijskim kavezima]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3493</user_id><user_firstLast_name>Đani Škalamera</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-3647</code><acronim><![CDATA[Cage-Cat]]></acronim><duration>12.01.2025 - 11.01.2032</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>873036</team_members_id><team_members_names><![CDATA[ Doktorand: Alen Martinko ]]></team_members_names><keywords_hr><![CDATA[koordinacijski kavezi, homogena kataliza, supramolekulska kemija, stereokemija, interakcije domaćin-gost, bioanorganska kemija]]></keywords_hr><keywords_en><![CDATA[coordination cage, homogeneous catalysis, supramolecular chemistry, stereochemistry, host-guest interactions, bioinorganic chemistry]]></keywords_en><summary_hr><![CDATA[Novi pristupi istraživanju multifunkcionalnih katalitičkih sustava vođeni su sve većom potrebom za razvitkom kiralnih lijekova i pojednostavljenjem njihove priprave. Koordinacijski kavezi, koji u principu sadržavaju nekoliko katalitički aktivnih metalnih atoma, nedovoljno su istraženi u enantioselektivnoj katalizi prijelaznim metalima. Visoka enantioselektivnost dobivena je s koordinacijskim kavezima isključivo u slučajevima prostornog ograničavanja katalizatora i/ili supstrata unutar šupljine kaveza koja oponaša ukopano aktivno mjesto enzima, s izvorom kiralnosti u neposrednoj blizini katalitički aktivnog centra. U okviru projektnog prijedloga propitujemo ovaj općeprihvaćen koncept i predlažemo novi katalitički sustav sastavljen od koordinacijskog kaveza u ulozi domaćina i kiralnog gosta. Radna hipoteza je da prijenos kiralnosti s kiralnog gosta na akiralni kavez može prouzročiti enantioselektivnost u katalitičkoj reakciji izvan kaveza. Predviđena je priprava katalitičkih koordinacijskih kaveza izrađenih od različitih prijelaznih metala i liganada koji sadržavanju tri prostorno razdvojene koordinirajuće skupine, a temeljeni su na amidnim, iminskim i acil-hidrazonskim skupinama. Eksperimentalnim i računalnim metodama istraživat će se interakcije domaćin-gost ovih koordinacijskih kaveza u svrhu identificiranja najprikladnijeg gosta za određeni kavez. Kompleksi domaćin-gost koristit će se kao katalizatori u enantioselektivnim reakcijama, uključujući multikatalizu. Također će se istražiti katalitičke reakcije u živim stanicama. Dobiveni rezultati doprinijet će razumijevanju prijenosa kiralnosti u katalitičkim koordinacijskim kavezima i upotrebi koordinacijskih kaveza kao katalitičkih lijekova koji reagiraju na različite podražaje.]]></summary_hr><summary_en><![CDATA[Research on novel approaches to multi-functional catalytic systems is governed by the ever-increasing need for chiral drug discovery, development, and simplification of synthetic procedures thereof. Coordination cages, potentially providing several catalytically active metal centres, are underexploited in enantioselective transition metal catalysis. High enantioselectivity with coordination cages was exclusively obtained in cases of catalyst and/or substrate confinement emulating an &#39;&#39;enzyme pocket&#39;&#39;, with the chiral source in close proximity of a catalytically active centre. Herein we challenge this well-established concept and propose the use of a catalytic system containing a coordination cage host and a chiral guest. The working hypothesis is that the transmission of chirality from the chiral guest to the achiral cage host can induce enantioselectivity of a catalytic reaction outside of the cage. In particular, catalytic coordination cages made of different transition metals and tripodal ligands with amide, imine, and acyl-hydrazone functionalities will be prepared. The host-guest chemistry of these coordination cages will be studied by experimental and computational methods in order to identify the most suitable guests for particular cages. These host-guest complexes will be used as catalysts in enantioselective reactions, including multicatalysis. Further attempts to perform catalytic reactions in living cells will be made. The overall results will contribute to understanding chirality transfer in catalytic coordination cages and establishing the use of coordination cages as multi-stimuli responsive catalytic metalo-drugs.]]></summary_en></project><project>
<id>18151</id><title_hr><![CDATA[Selekcija za poslove budućnosti: Valjanost i reakcije kandidata na digitalne selekcijske metode za mjerenje motiva za postignućem i aktivnog otvorenog mišljenja]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3974</user_id><user_firstLast_name>Zvonimir Galic</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-6518</code><acronim><![CDATA[SEL_FOW]]></acronim><duration>01.12.2025 - 30.11.2031</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Psihologija, </scie_field_hr><scie_field_en>Psychology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>873003</team_members_id><team_members_names><![CDATA[ Doktorand: Alma Džafić ]]></team_members_names><keywords_hr><![CDATA[profesionalna selekcija, budućnost rada, motiv za postignućem, aktivno otvoreno mišljenje, strojno učenje, analiza teksta, intervju]]></keywords_hr><keywords_en><![CDATA[personnel selection, future of work, achievement motive, active open-minded thinking, machine learning, text analysis, interview]]></keywords_en><summary_hr><![CDATA[Povećana automatizacija korištenjem umjetne inteligencije (UI) mijenja svijet rada velikom brzinom (Malhotra, 2021.). Projekt koji predlažemo bavi se razvojem i validacijom digitalnih selekcijskih postupaka (DSP) koji bi se mogli koristiti u profesionalnoj selekciji za procjenu karakteristika zaposlenika potrebnih za radna mjesta budućnosti. U središtu ovog projekta je procjena korisnosti postupaka strojnog učenja za procjenu psiholoških konstrukata u selekciji, polje istraživanja koje je gotovo potpuno neistraženo, uz nekoliko važnih iznimaka (npr. Campion et al., 2016.; Hickman et al., 2021.; 2022., Holtrop et al. ., 2022). U okviru ovog projekta želimo se fokusirati na korištenje računalno potpomognute analize teksta i automatiziranih video intervjua/video analitike za mjerenje specifičnih psiholoških konstrukata - motiva za postignućem i aktivnog otvorenog mišljenja kao osobina presudnih za radna mjesta budućnosti. Unutar četverogodišnjeg projekta planiramo provesti niz studija čiji će glavni ishod biti testovi valjanosti i reakcija kandidata na algoritme strojnog učenja za procjenu tih psiholoških karakteristika putem računalno potpomognute analize tekstualnih i multimodalnih podataka (tj. verbalne i neverbalne podatke) prikupljenih video intervjuom.]]></summary_hr><summary_en><![CDATA[Increased automation through the use of artificial intelligence (AI) has been changing the world of work at a rapid pace (Malhotra, 2021).  The project we are proposing deals with the development and validation of digital selection procedures (DSP) that could be used in personnel selection to assess employee characteristics needed for the future workplaces. At its core is the evaluation of the usefulness of machine learning (ML) procedures to assess psychological constructs within personnel selection, a research field that is almost untouched with few notable exceptions (e.g., Campion et al., 2016; Hickman et al., 2021; 2022, Holtrop et al., 2022). Within this project we want to focus on the use of computer-aided text analysis and automated video interviews/video analytics for the measurement of specific psychological constructs - achievement motive and actively open-minded thinking as the traits essential for the future workplace. Within the course of the four-year project we plan to conduct a set of studies whose main outcome will be tests of validity and applicant reactions to ML algorithms for assessing these psychological characteristics using textual and multimodal data (i.e., verbal and non-verbal data) .]]></summary_en></project><project>
<id>18156</id><title_hr><![CDATA[Usvajanje umjetne inteligencije u javnoj upravi s ciljem borbe protiv korupcije – AI-PACOR]]></title_hr><title_en><![CDATA[Adoption of Artificial Intelligence in Public Administration to combat CORruption - AI-PACOR]]></title_en><user_id>177</user_id><user_firstLast_name>Jelena Budak</user_firstLast_name><svouser_id>867841</svouser_id><svouser_firstLast_name>Aleksander Aristovnik</svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-6520</code><acronim><![CDATA[AI-PACOR]]></acronim><duration>15.12.2025 - 14.12.2028</duration><status>U tijeku</status><financ_value>154.430,00 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, Interdisciplinarne društvene znanosti, </scie_field_hr><scie_field_en>Economy, Interdisciplinary social sciences, </scie_field_en><institution_hr><![CDATA[Ekonomski institut Zagreb]]></institution_hr><institution_en><![CDATA[Institute of Economics in Zagreb]]></institution_en><team_members_id>5713, 27354, 25838, </team_members_id><team_members_names><![CDATA[Zoran Aralica, Bruno Škrinjarić, Tajana Barbić, ]]></team_members_names><keywords_hr><![CDATA[umjetna inteligencija, javno upravljanje, prihvaćanje novih tehnologija, korupcija, integritet javne uprave, povjerenje u institucije]]></keywords_hr><keywords_en><![CDATA[artificial intelligence, public governance, new technology adoption, corruption, public administration integrity, institutional trust]]></keywords_en><summary_hr><![CDATA[Uvođenje umjetne inteligencije (AI) može povećanjem transparentnosti i odgovornosti i radu javne uprave doprinijeti jačanju njezinog integriteta. Malo je istraživanja o upotrebi AI-a u javnoj upravi, prednostima i rizicima, a posebno nedostaju empirijska istraživanja o tome kako bi AI mogla doprinijeti integritetu javne uprave i borbi protiv korupcije. Projekt AI-PACOR odgovorit će na glavno istraživačko pitanje kako implementacija umjetne inteligencije u javnoj upravi doprinosi uklanjanju nepravilnosti, posebice suzbijanju korupcije. Teorija difuzije inovacija koristit će se za istraživanje usvajanja AI, a empirijska analiza koristit će anketne podatke prikupljene od lokalnih samouprava u Hrvatskoj i Sloveniji, u kombinaciji sa sekundarnim podacima i informacijama prikupljenim iz intervjua s relevantnim dionicima u obje zemlje. U tom kontekstu korištenje umjetne inteligencije, namjera korištenja, spremnost umjetne inteligencije, čimbenici usvajanja umjetne inteligencije, potencijal umjetne inteligencije u sprječavanju i otkrivanju nepravilnosti te identificirani rizici od korupcije u jedinicama lokalne samouprave usporedit će se u Hrvatskoj i Sloveniji. Utvrdit će se AI-intervencije kojima bi se mogla poboljšati transparentnost i odgovornost te ojačati mjere za borbu protiv korupcije u (lokalnoj) javnoj upravi. Ishod projekta bit će empirijski testiran model i verificirani analitički alat za procjenu usvajanja AI kao inovacije u javnoj upravi za borbu protiv korupcije, primjenjiv u drugim zemljama i različitim organizacijskim okruženjima. Rezultati istraživanja bit će objavljeni u kvalitetnim časopisima, a preporuke politika o usvajanju AI u javnoj upravi iz AI-PACOR projekta predstavit će se stručnoj javnosti i predstavnicima javne uprave obiju zemalja i inozemstva. Time će se podići svijest o potencijalu umjetne inteligencije u suzbijanju korupcije i postizanju šireg društvenog i gospodarskog učinka projekta. ]]></summary_hr><summary_en><![CDATA[Improving public integrity by increasing transparency and accountability might be boosted by the deployment of artificial intelligence (AI). Research on AI usage in public administration, its benefits and risks is scarce, in particular, empirical research on how AI might contribute to the integrity of public administration and anti-corruption efforts. AI-PACOR project will answer the main research question of how AI implementation in public administration contributes to seizing irregularities, especially to combat corruption. The innovation diffusion theory will be employed to investigate AI adoption, and empirical research will use survey data collected from local governments in Croatia and Slovenia, combined with secondary data and information gathered from interviews with relevant stakeholders in both countries. In this context, the specific issues will be addressed in Croatia and compared to Slovenia: AI usage, intention to use, AI readiness, factors of AI adoption, the AI’s potential in preventing and detecting irregularities and identified corruption risks in local government units in Croatia and Slovenia. Specific AI-driven interventions that could improve transparency and accountability and strengthen anti-corruption measures in (local) public administration will be identified. The project&#39;s outcome will be an empirically tested model and verified analytical tool to assess the adoption of AI as an innovation in public administration to combat corruption, applicable in other countries and different organizational settings. The research results will be published in quality journals, and policy recommendations on AI adoption in public administration, gathered from the AI-PACOR project, will be presented to the professional public and public administration representatives of both countries and internationally, thus raising awareness of the AI potential in curbing corruption and achieving a wider social and economic impact of the project. ]]></summary_en></project><project>
<id>18158</id><title_hr><![CDATA[Raščlamba zalihosti izoformi proteina Rac1 u protistu Dictyostelium discoideum]]></title_hr><title_en><![CDATA[]]></title_en><user_id>7715</user_id><user_firstLast_name>Igor Weber</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-6267</code><acronim><![CDATA[DiRac]]></acronim><duration>03.03.2026 - 02.03.2031</duration><status>U tijeku</status><financ_value>60,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>873327</team_members_id><team_members_names><![CDATA[ Doktorand: Sara Cerovski ]]></team_members_names><keywords_hr><![CDATA[stanično kretanje, Rho GTPaze, aktinski citoskelet, Dictyostelium, teorijsko modeliranje]]></keywords_hr><keywords_en><![CDATA[cell motility, Rho GTPases, actin cytoskeleton, Dictyostelium, theoretical modelling]]></keywords_en><summary_hr><![CDATA[Male GTPaze iz obitelji Rho dobro su poznate kao glavni regulatori aktinskog citoskeleta. Članovi potporodice Rac prvenstveno su uključeni u regulaciju stanične pokretljivosti, invazivnosti i adhezije, a njihova deregulacija povezana je s patogenezom brojnih bolesti. GTPaze iz grupe Rac primarno potiču stvaranje staničnih izbočina koje stvara aktin, ali izvješća o učincima nedostatka proteina Rac u različitim staničnim linijama nisu dosljedna. Poput sisavaca, amebe Dictyostelium izražavaju tri osnovne izoforme proteina Rac, ali pitanje njihove funkcionalne redundancije nije razjašnjeno. Ovo ćemo pitanje razmotriti provođenjem sveobuhvatne fenotipske karakterizacije nedavno kreiranih mutiranih stanica koje eksprimiraju parove ili samo pojedinačne izoforme Rac1. Usredotočit ćemo se na procese koji uključuju aktinski citoskelet, kao što su stanični rast, fagocitoza, makropinocitoza, migracija, adhezija, kemotaksija, citokineza i višestanični razvoj. Također ćemo proučavati ponašanje stanica kojima nedostaju izoforme Rac1 u trodimenzionalnim matricama, pod kompresijom, u struji tekućine i na ljepljivim površinama. Prekid signalnih putova koji vode do uočenih fenotipova istražit će se studijama lokalizacije i interakcija efektora GTPaza Rac1 u mutiranim stanicama. Aktivnost preostalih izoformi Rac1 u dvostrukim mutantima istražit će se praćenjem lokalizacije fluorescentne sonde specifične za Rac1-GTP. Nedavno smo otkrili da aktivnost proteina Rac1 u stanicama Dictyostelium može pokazivati oscilatornu dinamiku. Razvit ćemo elementarni deterministički i stohastički reakcijsko-difuzijski model dinamike Rac1 s očuvanjem mase koji će uključiti samo aktivaciju, deaktivaciju i difuziju. Usporedba između opažene i simulirane dinamike pojedinačnih izoformi Rac1 omogućit će nam da donesemo zaključke o specifičnim regulatornim mehanizmima koji kontroliraju vezanje proteina Rac1 na membranu i njegovo otpuštanje s membrane, te njihovu spregu s ciklusom aktivacije i deaktivacije.]]></summary_hr><summary_en><![CDATA[Small GTPases of the Rho family are well known as master regulators of the actin cytoskeleton. Members of the Rac subfamily are primarily involved in the regulation of cell motility, invasiveness and adhesion, and their dysregulation is associated with the pathogenesis of numerous diseases. Rac GTPases primarily promote the formation of actin-driven cell protrusions, but reports on the effects of Rac deficiency in different cell lineages are inconsistent. Similar to mammals, Dictyostelium amoebae express three basic Rac isoforms, but the question of their functional redundancy remains unresolved. We will address this question by performing a comprehensive phenotypic characterization of newly generated mutant cells expressing pairs or only single Rac1 isoforms. We will focus on processes involving the actin cytoskeleton, such as cell growth, phagocytosis, macropinocytosis, migration, adhesion, chemotaxis, cytokinesis and multicellular development. We will also study the behavior of Rac1-deficient cells in three-dimensional matrices, under compression, against flow and on adhesive surfaces. The disruption of signaling pathways leading to the observed phenotypes will be investigated by localization and interaction studies with Rac1 effectors in mutant cells. The activity of the remaining Rac1 isoforms in double mutants will be investigated by monitoring localization of a fluorescent probe specific for Rac1-GTP. We have recently discovered that Rac1 activity in Dictyostelium cells can exhibit oscillatory dynamics. We will develop elementary mass-conserving deterministic and stochastic reaction-diffusion models of Rac1 dynamics that include only activation, deactivation and diffusion. The comparison between the observed and simulated dynamics of single Rac1 isoforms will alow us to draw conclusions about specific regulatory mechanisms that control the recruitment of Rac1 to, and the release from, the membrane, and their coupling with the activation/deactivation cycle.]]></summary_en></project><project>
<id>18160</id><title_hr><![CDATA[Kvantna polja, simetrije i strune]]></title_hr><title_en><![CDATA[Quantum Fields, Symmetries, and Strings]]></title_en><user_id>867872</user_id><user_firstLast_name>Alexandros Spyridon Arvanitakis</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2025-02</proposal_call><code>UIP-2025-02-8940</code><acronim><![CDATA[QFIST]]></acronim><duration>01.04.2026 - 31.03.2031</duration><status>U tijeku</status><financ_value>288.382,80 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>870661, 870663, 870668, 869922, </team_members_id><team_members_names><![CDATA[Chris Blair, Dimitri Kanakaris Decavel, Saskia Demulder, Sara Zeko, ]]></team_members_names><keywords_hr><![CDATA[supergravitacija, supersimetrija, kvantna teorija polja, teorija struna, matematička fizika]]></keywords_hr><keywords_en><![CDATA[supergravity, supersymmetry, quantum field theory, string theory, mathematical physics]]></keywords_en><summary_hr><![CDATA[Naša grupa će pomaknuti granicu neperturbativnih izračuna u kvantnim teorijama polja, razotkriti geometriju unutarnjeg prostora koji kontrolira našu vidljivu stvarnost i odrediti oblik i sudbinu kvantnog prostor-vremena s pogledom prema novim fizikalnim modelima stvarnog svijeta. U tu svrhu  ćemo koristiti dvije inovacije u formi neinvertibilnih simetrija i kvantne lokalizacije. Eksplicitnije: prvi put ćemo predstaviti teoriju neinvertibilnih simetrija u kvantnoj neabelovoj Chern-Simonsovoj teoriji i iskoristiti je za rješavanje blisko povezanih problema baždarnih sučelja svjetskih ploha kao i neabelovskih dualnosti struna van semiklasične aproksimacije; pokrenut ćemo proučavanje kompaktifikacija teorije struna s  U-dualnim tranzicijskim funkcijama i njihovih popratnih fizičkih posljedica, kao i proučavanje promjene topologije izazvane U-dualnošću; i unaprijedit ćemo ambiciozan program točnih izračuna u (ne)supersimetričnim teorijama polja, počevši od neposrednog primjera trodimenzionalnih baždarnih teorija tipa Yang-Mills, s pogledom prema točnim rezultatima za kvantnu kromodinamiku u četiri dimenzije.]]></summary_hr><summary_en><![CDATA[Our group shall push the envelope of non-perturbative calculations in quantum field theories, unravel the geometry of the inner space that controls our observable reality, and determine the shape and fate of quantum spacetime with an eye towards new models for real-world physics. To this end we shall make crucial use of the two innovations of non-invertible symmetries and quantum localisation. More explicitly: we shall introduce for the first time a theory of non-invertible symmetries in quantum nonabelian Chern-Simons theory, and leverage it to solve the closely-related problems of gauged worldsheet interfaces as well as of nonabelian string dualities beyond tree-level; we shall initiate the study of string theory compactifications with U-duality patchings and their attendant physical consequences, as well as the study of U-duality induced topology change; and we shall advance an ambitious programme of exact calculations in (non-)supersymmetric field theories, beginning with the immediate example of three-dimensional gauge theories of Yang-Mills type, with an eye towards exact results for quantum chromodynamics in four dimensions.]]></summary_en></project><project>
<id>18161</id><title_hr><![CDATA[Standardizacija sustava upravljanja zemljištem]]></title_hr><title_en><![CDATA[Standardization of land administration systems]]></title_en><user_id>837</user_id><user_firstLast_name>Hrvoje Tomić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-6861</code><acronim><![CDATA[STALAS]]></acronim><duration>31.12.2025 - 30.12.2028</duration><status>U tijeku</status><financ_value>181.164,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Geodezija, Interdisciplinarne tehničke znanosti, </scie_field_hr><scie_field_en>Geodesy, Interdisciplinary technological sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Geodetski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Geodesy]]></institution_en><team_members_id>870395, 870536, 23204, 5698, 426, 870486, 3629, </team_members_id><team_members_names><![CDATA[Josip Križanović, Grgo Dželalija, Doris Pivac, Siniša Mastelić Ivić, Miodrag Roić, Lana Ivkovic, Darko Šiško, ]]></team_members_names><keywords_hr><![CDATA[katastar, zemljišne informacije, LADM, norme, upravljanje zemljištem]]></keywords_hr><keywords_en><![CDATA[cadastre, land information, LADM, standards, land administration]]></keywords_en><summary_hr><![CDATA[Sustavi upravljanja zemljištem u posljednje vrijeme prolaze radikalne promjene, a koje se prvenstveno odnose na prijelaz iz analognog u elektroničko okruženje. Na ovaj način značajno se pojednostavljuje održavanje podataka, povećava njihova dostupnost, razvidnost I omogućava diseminacija putem mrežnih usluga. Unatoč mnogim prednostima elektroničkog vođenja zemljišnih informacija, i dalje je prisutan analogni način razmišljanja. Tradicionalno, sustavi upravljanja zemljištem se sastoje od četiri glavne funkcije, a koje uključuju interese na zemljištu, vrijednost zemljišta, namjenu zemljišta i razvoj zemljišta. Svaka od navedenih funkcija je u naravi neovisna, ima vlastite procedure, organizaciju podataka, propise i poglede na važnost svojih podataka. Međutim, sve se oslanjaju na istu jedinicu upisa, a to je katastarska čestica. Prijelaz ovih heterogenih funkcija u integrirani sustav upravljanja zemljištem bi se mogao postići implementacijom međunarodnih normi poput ISO 19152 Modela područja upravljanja zemljištem (eng. ISO 19152 Land Administration Domain Model). U ovom projektnom prijedlogu, ispitati će se primjenjivost LADM norme na postojeće stanje referentnog sustava upravljanja zemljištem s ciljem razvoja standardiziranog sustava upravljanja zemljištem. Ciljevi uključuju: razvoj standardiziranog modela podataka te ispitivanje slučajeva upotrebe, a koji se temelje na svakodnevnim interakcijama korisnika i funkcija sustava upravljanja zemljištem.]]></summary_hr><summary_en><![CDATA[Land administration systems have recently been undergoing radical changes, primarily related to the transition from an analog to an electronic environment. In this way, the data maintenance is significantly simplified, availability and visibility are increased, and dissemination via web services is enabled. Despite the many advantages of electronic land administration, the analog way of thinking is still present. Traditionally, the land administration systems consist of four main functions, namely, land tenure, land value, land use and land development. Each of the said functions operates independently, has its own procedures, data organization, regulations and views on the importance of its data. However, they all rely on the same administrative unit, the cadastral parcel. The transition of these heterogeneous functions into an integrated land administration system could be achieved by implementing international standards such as ISO 19152 Land Administration Domain Model. In this project proposal, the applicability of the LADM standard to the existing state of the reference land administration system will be examined; with the aim of developing a standardized land administration system. Objectives include the development of a standardized data model and examination of use cases based on everyday user interactions with land administration functions.]]></summary_en></project><project>
<id>18162</id><title_hr><![CDATA[Uloga nezasićenih masnih kiselina u osjetljivosti osteosarkoma na oksidacijski stres i malignosti osteosarkoma]]></title_hr><title_en><![CDATA[The role of unsaturated fatty acids in the susceptibility of osteosarcoma to oxidative stress and osteosarcoma malignancy]]></title_en><user_id>26040</user_id><user_firstLast_name>Suzana Borovic Sunjic</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-5544</code><acronim><![CDATA[UFAOsOS]]></acronim><duration>30.01.2026 - 29.01.2029</duration><status>U tijeku</status><financ_value>117.000,00 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, Clinical sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>5101, 12333, 1261, 865951, </team_members_id><team_members_names><![CDATA[Josipa Vlainić, Neven Žarković, Ivone Jakaša, Ines Peremin, ]]></team_members_names><keywords_hr><![CDATA[Nezasićene masne kiseline, lipidna peroksidacija, oksidacijski stres, osteosarkom, imunost, neutrofili]]></keywords_hr><keywords_en><![CDATA[Unsaturated fatty acids, lipid peroxidation, oxidative stress, osteosarcoma, immunity, neutrophils,]]></keywords_en><summary_hr><![CDATA[Osteosarkom (OS) je najčešći primarni zloćudni tumor kosti mezenhimalnog porijekla. Posebno ga je teško liječiti jer je često otporan na kemo i radioterapiju čija osnova čini indukcija oksidativnog stresa. Prethodno smo pokazali da se normalne mezenhimalne stanice i OS stanice razlikuju u odgovoru na oksidacijski stres. Osim toga, OS stanice se razlikuju ovisno o tome jesu li više ili manje diferencirane. Pokazali smo da su stanični protektivni mehanizmi za zaštitu od oksidacijskog stresa slabije efikasni u diferenciranijim OS stanicama. Osim toga, diferencirane stanice sadrže više nezasićenih masnih kiselina (UFA), što ih čini osjetljivijim na oksidacijski stress. Stoga u ovom projektu želimo kvantificirati pojedine UFA i razjasniti ulogu pojedinih UFA u osjetljivosti na oksidacijski stres te ispitati njihovu ulogu u proliferaciji, invazivnosti i migraciji OS i odgovor imunološkog sustava vezan uz UFA. Ispitati ćemo razlike u odgovoru OS i osteoblasta. Ispitati ćemo učinak UFA na ekspresiju  molekula stanične membrane važnih za malignost OS kao što su npr PD-L1 i E-cadherin.  Ispitati ćemo učinak UFA na migraciju neutrofila i interakciju neutrofila i stanica OS te ulogu UFA u izbjegavanju imunološkog odgovora. Nadamo se da će rezultati istraživanja pomoći u razumjevanju tih procesa te naposlijetku pridonijeti daljnjem razvoju terapije OS.]]></summary_hr><summary_en><![CDATA[Osteosarcoma (OS) is the most common primary malignant bone tumor of mesenchymal origin. It is particularly difficult to treat because it is often resistant to chemo and radiotherapy, the basis of which is the induction of oxidative stress. We have previously shown that normal mesenchymal cells and OS cells differ in response to oxidative stress. In addition, OS cells differ depending on whether they are more or less differentiated. We have shown that cellular protective mechanisms for protection against oxidative stress are less efficient in more differentiated OS cells. In addition, differentiated cells contain more unsaturated fatty acids (UFAs), making them more susceptible to oxidative stress. Therefore, in this project we want to quantify individual UFAs and clarify the role of individual UFAs in sensitivity to oxidative stress, and examine their role in OS proliferation, invasiveness and migration and the response of the immune system related to UFAs. We will examine the differences in the response of OS and osteoblasts. We will examine the effect of UFA on the expression of cell membrane molecules important for OS malignancy, such as PD-L1 and E-cadherin. We will examine the effect of UFA on neutrophil migration and neutrophil-OS cell interaction, as well as the role of UFA in evading the immune response. We hope that the results of our research will help in understanding these processes and ultimately contribute to the further development of OS therapy.]]></summary_en></project><project>
<id>18163</id><title_hr><![CDATA[Razvoj nanosenzora temeljenih na površinski pojačanom Ramanovom raspršenju (SERS) za istraživanje G-kvadrupleksa DNA/RNA]]></title_hr><title_en><![CDATA[Development of nanosensors based on surface-enhanced Raman scattering (SERS) for the study of DNA/RNA G-quadruplexes]]></title_en><user_id>2809</user_id><user_firstLast_name>Snežana Miljanić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-9095</code><acronim><![CDATA[nanoSERS4Gq]]></acronim><duration>05.12.2025 - 04.12.2028</duration><status>U tijeku</status><financ_value>196.765,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, Fizika, </scie_field_hr><scie_field_en>Chemistry, Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>1175, 865602, 869881, 1271, 3684, 865902, </team_members_id><team_members_names><![CDATA[Adriana Kenđel, Petra Petrović, Tea Juračić, Nikša Krstulović, Dijana Pavlović Saftić, Vasile Chis, ]]></team_members_names><keywords_hr><![CDATA[G-kvadrupleks, površinski pojačano Ramanovo raspršenje, nanočestice, DNA/RNA, struktura, interakcije]]></keywords_hr><keywords_en><![CDATA[G-quadruplex, surface-enhanced Raman scattering, nanoparticles, DNA/RNA, structure, interactions]]></keywords_en><summary_hr><![CDATA[G-kvadrupleksi (G4) su strukture nukleinskih kiselina koje stvaraju ponavljajući slijedovi DNA i RNA bogati gvaninom. Strukturni oblici G4 razilikuju se ovisno o sastavu baza i duljini slijeda te prisutnosti vrsta koje ih stabiliziraju, kationa i/ili malih molekula. Strukture G4 utječu na funkcije nukleinskih kiselina, pri čemu suzbijaju umnožavanje tumorskih stanica. S obzirom na biološku važnost i potencijal u terapiji raka, interes za istraživanje strukturnih oblika G4 i dizajn lijekova koji potiču nastajanje i stabiliziraju G4 strukture u stalnom je porastu. Svrha ovog projekta je razviti metodu koja se temelji na površinski pojačanom Ramanovom raspršenju (engl. surface-enhanced Raman scattering, SERS) za proučavanje struktura G-kvadrupleksa i njihovih interakcija s malim organskim molekulama. SERS spektroskopija je vibracijska tehnika koja omogućava osjetljivu detekciju molekula u blizini nanostrukturiranih metalnih površina. Projekt je stoga usmjeren na razvoj SERS senzorskih platformi, primjenjivih za istraživanje struktura nukleinskih kiselina. Pripravit će se i karakterizirati niz metalnih nanočestica koje će se razlikovati prema vrsti metala (zlato i srebro), obliku (sfere i zvijezde) i površinskom naboju (neutralne, negativne i pozitivne) te modifikaciji površine. Uz nanočestice nemodificirane površine, pripravit će se metalne nanočestice funkcionalizirane nukleotidnim slijedovima, što će omogućiti strukturnu analizu primjenom SERS nanosenzora bez oznake i SERS nanosenzora modificiranih oligonukleotidom. Provest će se strukturna analiza različitih oblika G4, nakon koje će uslijediti istraživanje vezanja malih molekula na G4. Kako bi se istražila selektivnost malih molekula za G-kvadrupleks u odnosu na dvostruku uzvojnicu DNA, pripravit će se SERS senzorske platforme za istraživanje dupleksa DNA. SERS nanosenzori za G-kvadrupleks i dupleks DNA primijenit će se za otkrivanje načina i mjesta vezanja malih, biološki aktivnih molekula.]]></summary_hr><summary_en><![CDATA[G-quadruplexes (G4) are nucleic acid structures formed by repetitive guanine-rich DNA and RNA sequences. The structural forms of G4 differ depending on the length and base composition of the sequence, as well as the presence of stabilizing species, such as cations and/or small molecules. G4 structures affect nucleic acid functions, suppressing proliferation of tumour cells. Considering their biological relevance and potential in anticancer therapy, there is a growing interest in research of G4 structural forms and design of drugs which induce the formation and stabilize G4 structures. The main goal of this project is to develop a method based on surface-enhanced Raman scattering (SERS) for the study of G-quadruplex structures and their interactions with small organic molecules. SERS spectroscopy is a vibrational technique that enables sensitive detection of molecules near nanostructured metal surfaces. The project is therefore aimed at the development of SERS sensing platforms, applicable for studying nucleic acid structures. A series of metal nanoparticles differing in metal type (gold and silver), shape (sphere and star) and surface charge (neutral, negative, and positive) will be prepared and characterized. In addition to surface-unmodified nanoparticles, the metallic nanoparticles will be functionalized with nucleotide sequences, thus allowing structural analysis using label-free SERS nanosensors and oligonucleotide-modified SERS nanosensors. Structural analysis of various G4 forms will be carried out, followed by research on the binding of small molecules to G4. To investigate the selectivity of small molecules for G-quadruplex over double helical DNA structure, SERS sensing platforms will be also prepared for the study of duplex DNA. SERS nanosensors for G-quadruplex and duplex DNA will be applied for revealing binding modes and binding sites of biologically active small molecules.]]></summary_en></project><project>
<id>18164</id><title_hr><![CDATA[Interaktivni učinci mikroplastike i nanosrebra na kopnene i vodene biljke i alge ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>12729</user_id><user_firstLast_name>Petra Peharec Štefanić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-1009</code><acronim><![CDATA[MINION]]></acronim><duration>20.01.2026 - 19.01.2032</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>873059</team_members_id><team_members_names><![CDATA[ Doktorand: Dona Vuković ]]></team_members_names><keywords_hr><![CDATA[mikroplastika, nanočestice srebra, fitotoksičnost, oksidacijski stres, fotosinteza, (gliko)proteini, Allium, Lemna, Chlorella]]></keywords_hr><keywords_en><![CDATA[microplastics, silver nanoparticles, phytotoxicity, oxidative stress, photosynthesis, (glyco)proteins, Allium, Lemna, Chlorella]]></keywords_en><summary_hr><![CDATA[Potražnja za plastikom kontinuirano raste u različitim područjima ljudskih aktivnosti, a velik dio proizvedene plastike završava u okolišu kao otpad, stvarajući tako značajan ekološki izazov. Budući da nije biorazgradiva, plastika ostaje u okolišu jako dugo pa je plastični otpad pod kontinuiranim procesom razgradnje koji dovodi do fragmentacije plastike na manje dijelove, od većih plastičnih ostataka do mikro (MP) i nano (NP) ) dimenzija čestica. Čestice plastike ostaju u kopnenom i vodenom okolišu te u atmosferi i time ugrožavaju živi svijet. Dimenzije plastike i njezina sposobnost adsorpcije toksičnih organskih i anorganskih zagađivača, kao i osnovna struktura polimera, ključne su varijable u određivanju razine toksičnosti plastike u izloženim organizmima. Posebno su zanimljive studije koje se bave interakcijama između MP i nanočestica metala, posebice nanočestica srebra (AgNP), zbog njihove široke rasprostranjenosti u tlu, vodi i zraku te njihove toksičnosti za većinu organizama. U našem projektu predlažemo inovativno istraživanje o interaktivnim učincima MP i AgNP na biljke i zelene alge, ključne komponente svakog ekosustava i prehrambenog lanca. U projektu ćemo istražiti dvije vrste mikroplastike (PS-MP i PMMA-MP) i AgNP s dvije vrste omotača (PVP- i CTAB-AgNP) na kopnenoj biljci Allium cepa, vodenoj biljci Lemna minor i zelenoj algi Chlorella vulgaris kako bi se razjasnila priroda njihove interakcije i o čemu ona ovisi. Štoviše, predloženi su inovativni pristupi lokalizaciji i detekciji MP. Saznanja o interakcijama MP i AgNP općenito su vrlo skromna, a za biljke i zelene alge do sada postoji samo jedna objavljena studija.]]></summary_hr><summary_en><![CDATA[The demand for plastic is continuously growing in various areas of human activity and large amounts of plastic end up in the environment as waste, thus creating a significant environmental challenge. Being non-biodegradable, plastic remains in the environment for a very long time and therefore plastic waste is under a continuous process of degradation that leads to the fragmentation of plastic into smaller parts, from larger plastic debris to micro (MP) and nano (NP) dimension of particles. Plastic particles remain in the land and water environment and in the atmosphere, thus endangering the living world. The dimensions of the plastic and its ability to adsorb toxic organic and inorganic pollutants, as well as the basic structure of the polymer, are key variables in determining the level of plastic toxicity in exposed organisms. Particularly interesting are studies dealing with interactions between MP and metal nanoparticles, especially silver nanoparticles (AgNPs), due to their worldwide distribution in soil, water and air, and their toxicity to most organisms. In our project, we propose innovative research on the interactive effects of MP and AgNP on plants and green algae, key components of every ecosystem and food chain. In the project we will investigate two types of microplastics (PS-MP and PMMA-MP) and AgNPs with two types of coatings (PVP- and CTAB-AgNPs) on the terrestrial plant Allium cepa, aquatic plant Lemna minor, and the green alga Chlorella vulgaris to elucidate the nature of their interactions and what it depends on. Moreover, the innovative approaches to MP localization and detection are proposed. Knowledge about the interactions of MPs and AgNPs is generally very modest, and for plants and green algae there is only one published study so far. ]]></summary_en></project><project>
<id>18165</id><title_hr><![CDATA[Hiperheurističko upravljanje raskrižjima s prometnim svjetlima]]></title_hr><title_en><![CDATA[Hyper-heuristic Traffic Signal Control]]></title_en><user_id>6984</user_id><user_firstLast_name>Domagoj Jakobović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-6043</code><acronim><![CDATA[HyperTraC]]></acronim><duration>22.12.2025 - 21.12.2028</duration><status>U tijeku</status><financ_value>154.820,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, Tehnologija prometa i transport, </scie_field_hr><scie_field_en>Computer sciences, Transport technology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>2616, 29067, 26484, </team_members_id><team_members_names><![CDATA[Edouard Ivanjko, Mladen Miletić, Marko Čupić, ]]></team_members_names><keywords_hr><![CDATA[hiperheuristika, evolucijski algoritmi, strojno učenje, upravljanje raskrižjem, dinamičko raspoređivanje]]></keywords_hr><keywords_en><![CDATA[hyper-heuristics, evolutionary algorithms, machine learning, traffic signal control, dynamic scheduling]]></keywords_en><summary_hr><![CDATA[Upravljanje semaforima predstavlja važno istraživačko područje u razvoju pametnih gradova. Potpomognuto učenje (reinforcement learning, RL) se sve više primjenjuje na ovaj problem. Međutim, postojeće metode RL imaju nekoliko problema. Jedan od izazova proizlazi iz potrebe za definiranjem odgovarajućeg sustava nagrađivanja. Razvoj funkcije nagrade zahtijeva veliko znanje i stručnost, budući da je teško odrediti učinkovitost pojedinačne akcije, poput definiranja sljedeće faze semafora ili produljenja trajanja trenutne faze. U slučajevima nepredviđenih promjena, nagrada može biti ovisna o promjenama, a određene akcije mogu biti smatrane nepovoljnima, iako su preporučene. Osim toga, naučenu upravljačku politiku je teško interpretirati i objasniti. Objašnjivost potpomognutog učenja vrlo je aktualna tema koja još uvijek nije dovoljno istražena. Jedan mogući pristup rješavanju ovog problema je njegovo promatranje kao problema raspoređivanja, u kojem se resursi (prometna infrastruktura) moraju dodijeliti akcijama (vozilima) u dinamičkim uvjetima. Umjesto optimizacije rasporeda, što je često neizvedivo u dinamičkom okruženju, može se primijeniti hiperheuristički pristup za stvaranje heuristike upravljanja prilagođene specifičnom problemu. Prethodna istraživanja pokazala su da genetsko programiranje (GP) i slične metode evolucijskog računarstva (EC) imaju veliki potencijal kao hiperheuristike kada se koriste za automatsko generiranje novih heuristika.  Cilj ovog projekta je primijeniti hiperheuristički pristup na problem upravljanja semaforima kako bi se prevladale poteškoće potpomognutog učenja, koristeći EC za evoluciju agenata koji upravljaju prometnim signalima. U projektu će se primijeniti višekriterijska optimizacija, kako bi se uzele u obzir različite metrike poput kašnjenja i emisije stakleničkih plinova. Također će se istražiti metode skupnog učenja te kooperativna i kompetitivna koevolucija kako bi se poboljšala sposobnost generalizacije evoluiranih agenata.]]></summary_hr><summary_en><![CDATA[Traffic Signal Control (TSC) is a major research focus in the development of smart cities. Among the possible solutions, reinforcement learning (RL) is increasingly applied to this problem. However, the existing RL methods have several problems. One challenge arises from the need to develop an appropriate reward system. Defining a reward function usually requires a great deal of knowledge and expertise, as it can be very difficult to estimate the effectiveness of a single action, such as determining the next traffic signal phase or extending the duration of the current one. The reward can be affected by the changes and some actions might be considered unfavourable even though they are optimal. In addition, the learned control policy is hard to interpret and may be difficult to explain. The explainability of RL is a very recent topic that has not yet been sufficiently addressed. One possible approach to solving this problem is to view it as a scheduling problem in which resources (transportation infrastructure) must be allocated to actions (vehicles) under dynamic conditions. Instead of optimizing a schedule, which is usually not possible in a dynamic environment, one can apply a hyper-heuristic approach to create a scheduling heuristic tailored to the problem at hand. Previous research has shown that genetic programming (GP) and similar evolutionary computation (EC) methods have great potential as hyper-heuristics when used to automatically generate new heuristics. The aim of this project is to apply a hyper-heuristic approach to the TSC problem, to overcome the difficulties encountered when using RL, by using EC to evolve agents that control traffic signalling systems. In this project, multi-objective optimisation will be applied to consider multiple criteria such as time delays and greenhouse gas emissions in traffic management. It will also include ensemble methods, cooperative and competitive coevolution to improve the generalisation ability of evolved agents. ]]></summary_en></project><project>
<id>18166</id><title_hr><![CDATA[Razvoj hiperheuristika za okruženje nesrodnih strojeva s dodatnim sredstvima]]></title_hr><title_en><![CDATA[Hyper-Heuristic Design for Unrelated Machines Environment with Auxiliary Resources]]></title_en><user_id>26109</user_id><user_firstLast_name>Mateja Đumić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2025-02</proposal_call><code>UIP-2025-02-8039</code><acronim><![CDATA[HyDUMAR]]></acronim><duration>01.04.2026 - 31.03.2031</duration><status>U tijeku</status><financ_value>237.850,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Fakultet primijenjene matematike i informatike]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, School of Applied Mathematics and Informatics]]></institution_en><team_members_id>26096, 870435, </team_members_id><team_members_names><![CDATA[Rebeka Čorić, Josipa Sabljo, ]]></team_members_names><keywords_hr><![CDATA[hiperheuristika, genetičko programiranje, problem raspoređivanja, okruženje nesrodnih strojeva, dodatna sredstva, pravila raspoređivanja]]></keywords_hr><keywords_en><![CDATA[hyper-heuristic, genetic programming, scheduling problem, unrelated machines environment, auxiliary resources, dispatching rules]]></keywords_en><summary_hr><![CDATA[Problem raspoređivanja u okruženju nesrodnih strojeva je najopćenitija varijanta problema raspoređivanja u kojima se posao treba izvršiti na jednom stroju te je kao takav primjenjiv u problemima kao što su višeprocesorsko raspoređivanje, proizvodnja poluvodiča i u fotolitografskim radionicama. U sklopu ovog projekta promatrat će se problem u okruženju nesrodnih strojeva koji ima dodatna sredstva. Dodatna sredstva potrebna za izvršavanje poslova mogu biti u vidu ljudske snage ili materijala potrebnih za odrađivanje poslova. Jedan od načina rješavanja ovog problema su problemski specifične heuristike u koje se ubrajaju pravila raspoređivanja. Pravila raspoređivanja su brza i jednostavna heuristika koja je primjenjiva i u dinamičkim uvjetima u kojima nisu poznate sve informacije u sustavu. S obzirom da se problemi u praksi većinom odvijaju upravo u dinamičkim uvjetima, pravila raspoređivanja se često koriste u praksi. No, kreiranje ovih pravila je izazovan zadatak koji uglavnom uključuje problemski specifična znanja zbog čega ih je potrebno posebno kreirati za svaki kriterij koji se želi optimirati i za svaku varijantu problema.Ideja ovog projekta je razviti hiperheurističku metodu koja će moći generirati pravila raspoređivanja za problem raspoređivanja u okruženju nesrodnih strojeva s dodatnim sredstvima. U sklopu projekta identificirat će se različite inačice ovog problema te dati smjernice kako koristiti predloženu hiperheurističku metodu za svaku od njih. Dodatno, predložena hiperheuristička metoda prilagodit će se kako bi bila primjenjiva za razvoj pravila raspoređivanja koja su svjesna svoje dinamičke okoline i koja mogu optimirati više kriterija istovremeno. U sklopu projekta za razvijena pravila raspoređivanja ispitat će se različite metode koje bi mogle dodatno poboljšati njihove rezultate. Konačno, napravit će se dodatna prilagodba razvijene heuristike kako bi se ona mogla primijeniti na problemu raspoređivanja prisutnom u fotolitografskim radionicama.]]></summary_hr><summary_en><![CDATA[The scheduling problem in an unrelated machines environment is the most general variant of scheduling problems in which a job must be executed on a single machine. As such, it is applicable to problems such as multiprocessor scheduling, semiconductor manufacturing, and photolithography workshops. This project will focus on the scheduling problem in an unrelated machines environment with auxiliary resources. These auxiliary resources are required for job execution and include human work or materials necessary for executing jobs. One approach to solving this problem includes problem-specific heuristics, among which dispatching rules are the most common. Dispatching rules are a fast and simple heuristic approach applicable in dynamic environments where not all system information is known in advance. Dispatching rules are widely used since real-world problems often occur in dynamic conditions. However, designing these rules is a challenging task that typically requires problem-specific knowledge, making it necessary to create specific rules for each optimization criterion and problem variant.This project aims to develop a hyper-heuristic method capable of generating dispatching rules for the scheduling problem in an unrelated machines environment with auxiliary resources. Different variants of this problem will be identified as part of the project, and guidelines will be provided on applying the proposed hyper-heuristic method to each. Additionally, the proposed hyper-heuristic method will be adapted to develop dispatching rules that are aware of their dynamic environment and capable of optimizing multiple criteria simultaneously. The project will also examine different methods for further improving the performance of the developed dispatching rules. Finally, additional adaptations of the developed heuristic will be made to ensure its applicability to scheduling problems in photolithography workshops.]]></summary_en></project><project>
<id>18169</id><title_hr><![CDATA[Metafizičke teme u hrvatskih renesansnih arisotelovaca]]></title_hr><title_en><![CDATA[Metaphysical Themes in Croatian Renaissance Aristotelians]]></title_en><user_id>1441</user_id><user_firstLast_name>Pavel Gregorić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-1552</code><acronim><![CDATA[MeTopCro]]></acronim><duration>02.12.2025 - 01.12.2028</duration><status>U tijeku</status><financ_value>120.291,00 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filozofija, Filologija, Povijest, </scie_field_hr><scie_field_en>Philosophy, Philology, History, </scie_field_en><institution_hr><![CDATA[Institut za filozofiju]]></institution_hr><institution_en><![CDATA[Institute for Philosophy in Zagreb]]></institution_en><team_members_id>3931, 748, 870674, 29189, </team_members_id><team_members_names><![CDATA[Gorana Stepanić, Mihaela Girardi-Karšulin, Eva Del Soldato, Borna Treska, ]]></team_members_names><keywords_hr><![CDATA[Aristotel, renesansa, Dubrovnik, filozofija, znanost, kozmologija, besmrtnost duše]]></keywords_hr><keywords_en><![CDATA[Aristotle, Renaissance, Dubrovnik, philosophy, science, cosmology, immortality of the soul]]></keywords_en><summary_hr><![CDATA[U projektu „Metafizičke teme u hrvatskih renesansnih aristotelovaca“ (MeTopCro) istražit ćemo doprinos hrvatskih aristotelovaca raspravama koje su reprezentativne za cjelokupnu filozofiju u razdoblju renesanse. Konkretnije, (1) proučit ćemo i dati cjelovitu ocjenu  Gučetićeva poimanje besmrtnosti duše, što je problem renesansne filozofije par excellence, (2) produbit ćemo sliku Gučetićeva književno-filozofskog stvaralaštva fokusiranim istraživanjima arhivske građe, (3) proučit ćemo i ocijeniti Dubrovčaninovu racionalnu kritiku astrologije iz perspektive astronomije kao matematičke znanosti, (4) ispitat ćemo Frkićeve smjele inovacije u metafizici, konkretno u kozmologiji gdje je odustao od aristotelovske teze o petom elementu kao građi nebeskih tijela te u inovativnom tumačenju antičkog aksioma da ništa ne može proizaći iz ničega, što je valjalo pomiriti s naukom iz biblijske Knjige Postanka. Ova četri pravca istraživanja pridnonijet će dobro utemeljenoj procjeni izvornosti i doprinosa hrvatskog renesansnog aristotelizma europskoj filozofiji i znanosti. ]]></summary_hr><summary_en><![CDATA[In the project &#39;&#39;Metaphysical Themes in Croatian Renaissance Aristotelians&#39;&#39; (MeTopCro) we will investigate the contributions of Croatian Aristotelians to debates that are representative of Renaissance philosophy as a whole. Specifically, (1) we will study and provide a comprehensive assessment of Gučetić’s conception of  the immortality of the soul, a quintessential problem of Renaissance philosophy. (2) We will deepen our understanding of Gučetić’s output through focused research of archival materials. (3) We will examine and evaluate Dubrovčanin’s rational critique of astrology from the perspective of astronomy as a mathematical science. (4) We will analyze Frkić’s bold innovations in metaphysics, particularly in cosmology, where he abandoned the Aristotelian fifth element as the substance of celestial bodies, as well as Frkić&#39;s innovative interpretation of the ancient axiom that &#39;&#39;nothing comes from nothing,&#39;&#39; which had to be reconciled with the teachings of the Book of Genesis. These four research directions will contribute to a well-founded assessment of the originality and contribution of Croatian Renaissance Aristotelianism to European philosophy and science. ]]></summary_en></project><project>
<id>18171</id><title_hr><![CDATA[Integrirana morfološka, genetska i biokemijska identifikacija i karakterizacija samoniklih jestivih gljiva u Hrvatskoj]]></title_hr><title_en><![CDATA[Integrated morphological, genetic and biochemical identification and characterization of wild edible mushrooms in Croatia]]></title_en><user_id>26929</user_id><user_firstLast_name>Ivan Širić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-9719</code><acronim><![CDATA[GenBioM]]></acronim><duration>29.12.2025 - 28.12.2028</duration><status>U tijeku</status><financ_value>199.715,60 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, Interdisciplinarne biotehničke znanosti, </scie_field_hr><scie_field_en>Agriculture, Interdisciplinary biotechnical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Agronomski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Agriculture]]></institution_en><team_members_id>19017, 870343, 20368, 6046, 870408, 23621, 22744, 870161, 19027, </team_members_id><team_members_names><![CDATA[Aleksandra Perčin, Tena Radočaj, Sanja Slunjski, Nives Marušić Radovčić, Jelena Lončar, Boro Mioč, Ivan Vnučec, Pankaj Kumar, Nataša Hulak, ]]></team_members_names><keywords_hr><![CDATA[gljive, taksonomija, nutritivna vrijednost, tlo, mikrobna raznolikost, teški metali, zdravstveni rizici]]></keywords_hr><keywords_en><![CDATA[mushrooms, taxonomy, nutritional value, soil, microbial diversity, heavy metals, health risks]]></keywords_en><summary_hr><![CDATA[Predloženi projekt pridonijet će poboljšanju trenutnog razumijevanja raznolikosti samoniklih gljiva kroz njihovu morfološku, genetsku i biokemijsku karakterizaciju u Hrvatskoj. Tijekom tri godine kroz projekt će se proučavati osam samoniklih vrste gljiva na dvije regije u Hrvatskoj. Predloženim projektom će se uspostaviti odnosi između mikroklime, tla, mikrobnih zajednica i sastava gljiva tla, korisnih za ekološku otpornost, očuvanje okoliša, sigurnost hrane i održivo korištenje samoniklih gljiva. Najvažniji ciljevi su: 1) utvrditi taksonomske, fenotipske i mikroskopske zanačajke te biokemijski i nutritivni sastav odabranih samoniklih gljiva; 2) utvrditi kemijska svojstva tla i mikroklimatske uvjete koji utječu na rasprostranjenost samoniklih gljiva; 3) utvrditi korelacije između svojstava tla i mikroklime te prostornog rasporeda samoniklih gljiva; 4) analizirati mikrobnu raznolikost u tlu povezanu sa zajednicama samoniklih gljiva u različitim ekosustavima; 5) procijeniti bioakumulaciju teških metala u gljivama i procijeniti potencijalne zdravstvene rizike; i 6) širiti rezultate istraživanja dionicima i unaprijediti znanstveno-istraživačke potencijal fakulteta. Istraživanje će obuhvatiti: a) fizikalno-kemijsku i elementarnu analizu tla radi utvrđivanja stanišnih uvjeta; b) genetsku identifikaciju vrsta gljiva; c) analizu mikrobne zajednice za proučavanje interakcija gljiva i bakterija; d) biokemijske analize u svrhu utvrđivanja hranjivog i bioaktivnog sastava gljiva; i e) analizu teških metala u tlu i plodnim tjelima gljiva za procjenu razine kontaminacije i potencijalnih rizika za zdravlje ljudi. Rezultati projekta će podržati strategije očuvanja ekosustava temljem spoznaja o bioraznolikosti gljiva, prakse održivog branja gljiva i procjenu rizika konzumacijom istih. Ishodi projekta također će doprinijeti razvoju funkcionalne hrane, prirodnih dodataka prehrani i novih farmaceutskih spojeva.]]></summary_hr><summary_en><![CDATA[The proposed project will contribute to enhancing the current understanding of wild mushroom diversity through morphological, genetic and biochemical characterization in Croatia. During three years, the project will study two different regions of Croatia and eight wild edible mushrooms. It will help to establish relationships among microclimate, soil, microbial communities, and mushroom constituents useful for ecological resilience, environmental conservation, food safety, and sustainable utilization of wild mushrooms. The specific objectives are to: 1) determine taxonomic, phenotypic, microscopic biochemical, and nutritional characteristucs of selected mushroom communities; 2) determine soil chemical and microclimate properties of selected mushroom communities; 3) study the influence of soil and microclimate properties on distribution patterns of mushroom communities 4) study the microbial diversity in the soil of selected mushroom communities across various environmental gradients; 5) determine microelements and heavy metal bioaccumulation and health risks in selected mushroom communities; and 6) disseminate research findings to stakeholders and enhance the scientific research capabilities of the institute. The research will include: a) soil physicochemical and elemental analysis to determine habitat conditions; b) genetic identification of mushroom species; C) microbial community analysis to study fungal-bacterial interactions; d) biochemical assays to determine the nutritional and bioactive composition of mushrooms; and e) heavy metal analysis in soil and mushroom tissues to assess contamination levels and potential risks. The results will support ecosystem conservation strategies based on findings on mushroom biodiversity, sustainable mushroom harvesting practices and risk assessment of mushroom consumption. The project outcomes will also contribute to the development of functional foods, natural food supplements and novel pharmaceutical compounds.]]></summary_en></project><project>
<id>18182</id><title_hr><![CDATA[Kompulzivno kockanje: učinkovitost duboke transkranijalne magnetske stimulacije zavojnicom H7]]></title_hr><title_en><![CDATA[COMpulsive gambling: Efficacy of DEEP Transcranial magnetic stimulation with H7 COIL]]></title_en><user_id>13496</user_id><user_firstLast_name>Igor Filipcic</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-7016</code><acronim><![CDATA[COMET-7]]></acronim><duration>22.12.2025 - 21.12.2028</duration><status>U tijeku</status><financ_value>98.500,00 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Kliničke medicinske znanosti, Javno zdravstvo i zdravstvena zaštita, </scie_field_hr><scie_field_en>Clinical sciences, Public health and health services, </scie_field_en><institution_hr><![CDATA[Psihijatrijska bolnica "Sveti Ivan", Zagreb]]></institution_hr><institution_en><![CDATA[Psychiatric Hospital "Sveti Ivan" Zagreb]]></institution_en><team_members_id>868720, 13313, 870648, 25893, 868718, 868715, 870591, 870177, 869976, </team_members_id><team_members_names><![CDATA[Sandra Vuk Pisk, Vladimir Grošić, Ena Ivezić, Davor Bodor, Željko Milovac, Tomislav Gajšak, Karla Laškarin, Katarina Matić, Majda Grah, ]]></team_members_names><keywords_hr><![CDATA[Poremećaj kockanja, Patološko kockanje, Repetitivna transkranijalna magnetska stimulacija,  duboki TMS, Neurostimulacija]]></keywords_hr><keywords_en><![CDATA[Gambling Disorder, Pathological gambling, Repetitive Transcranial Magnetic Stimulation, deepTMS, Neurostimulation]]></keywords_en><summary_hr><![CDATA[Poremećaj kockanja (PK) ozbiljan je javnozdravstveni problem s izraženim socijalnim, psihološkim i ekonomskim posljedicama te povećanim rizikom od psihijatrijskih komorbiditeta i suicidalnosti. Postojeće terapije često su nedovoljno učinkovite. Repetitivna transkranijalna magnetska stimulacija (rTMS) pokazala je pozitivne učinke u liječenju impulzivnih i ovisničkih poremećaja, no njezini učinci na PK nisu sustavno istraženi.  Dosadašnje studije liječenja PK rTMS-om koristile su različite zavojnice, ali primjena H7 zavojnice u dosad nije ispitivana unatoč neurobiološkim preklapanjima PK-a i opsesivno-kompulzivnog poremećaja za koji je Američka agencija za hranu i lijekove odobrila H7. Ovo istraživanje prvo će testirati učinak  H7 zavojnice na PK što ga čini inovativnim i klinički važnim. Cilj je ispitati učinkovitost i sigurnost rTMS-a visoke frekvencije s H7 zavojnicom u liječenju PK-a. Istraživanje će biti dvostruko slijepo, randomizirano i placebo-kontrolirano te će se provoditi u Klinici za psihijatriju Sveti Ivan, Hrvatska. Uključit će 60 muškaraca s dijagnosticiranim PK-om, dobi 18 do 64 godine, koji započinju standardno liječenje u dnevnoj bolnici. Sudionici će biti randomizirani u dvije skupine: eksperimentalnu (rTMS s H7 ) i kontrolnu (pasivna-zavojnica). Intervencija će trajati šest tjedana, uz svakodnevne 20-minutne seanse. Primarni ishod bit će promjena težine PK-a, mjerena ljestvicom Gambling Symptom Assessment Scale. Sekundarni ishodi uključivat će žudnju za kockanjem, stopu odustajanja od terapije, simptome depresivnosti i anksioznosti, kvalitetu života te varijabilnost srčanog ritma. Sigurnost rTMS-a procjenjivat će se praćenjem neželjenih događaja. Očekuje se da će ovo istraživanje omogućiti procjenu potencijala rTMS-a s H7 zavojnicom u liječenju PK-a, otvoriti nove terapijske mogućnosti, smanjiti stopu odustajanja od liječenja te poboljšati ukupnu učinkovitost terapijskih intervencija, uz potencijalno smanjenje društvenih troškova povezanih s PK-om.]]></summary_hr><summary_en><![CDATA[Gambling disorder (GD) is a serious public health issue with significant social, psychological, and economic consequences, as well as an increased risk of psychiatric comorbidities and suicidality. Existing treatments are often insufficient. Repetitive transcranial magnetic stimulation (rTMS) has shown efficacy in treating impulsive and addictive disorders, but its effects on GD remain underexplored. Previous rTMS studies on GD have used different coils, but the H7-coil has not yet been investigated, despite neurobiological overlaps between GD and obsessive-compulsive disorder, for which the U.S. Food and Drug Administration has approved the rTMS-H7 protocol. This study will be the first to assess the effects of the H7-coil on GD, making it both innovative and clinically significant. The aim is to evaluate the efficacy and safety of high-frequency rTMS-H7 in GD treatment. This double-blind, randomized, placebo-controlled study will be conducted at the University Psychiatric Clinic Sveti Ivan, Croatia, including 60 males aged 18–64 diagnosed with GD who are initiating standard treatment in a day hospital setting. Participants will be randomized into an experimental group (rTMS-H7) and a control group (sham-coil). The intervention will last six weeks, with daily 20-minute sessions. The primary outcome is the change in GD severity, measured using the Gambling Symptom Assessment Scale. Secondary outcomes include gambling craving, treatment dropout rate, depressive and anxiety symptoms, quality of life, and heart rate variability. Safety will be assessed by monitoring adverse events. This study is expected to provide insights into the therapeutic potential of rTMS-H7 for GD, introduce novel treatment options, reduce dropout rates, and improve overall intervention efficacy, with the potential to lower the societal costs associated with GD.]]></summary_en></project><project>
<id>18184</id><title_hr><![CDATA[Rano usvajanje i razumijevanje polisemnih riječi]]></title_hr><title_en><![CDATA[Early acquisition and comprehension of polysemous words]]></title_en><user_id>27334</user_id><user_firstLast_name>Ana Werkmann Horvat</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2025-02</proposal_call><code>UIP-2025-02-5422</code><acronim><![CDATA[POLI-ACQ]]></acronim><duration>01.04.2026 - 31.03.2031</duration><status>U tijeku</status><financ_value>250.566,88 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filologija, Interdisciplinarne humanističke znanosti, </scie_field_hr><scie_field_en>Philology, Interdisciplinary humanities, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>23362, 20102, 870637, 25250, </team_members_id><team_members_names><![CDATA[Mia Batinić Angster, Ivana Trtanj, Jakov Proroković, Sara Košutar, ]]></team_members_names><keywords_hr><![CDATA[polisemija, usvajanje jezika, razumijevanje jezika, hrvatski, metafora]]></keywords_hr><keywords_en><![CDATA[polyemy, language acquisition, language comprehension, Croatian, metaphor]]></keywords_en><summary_hr><![CDATA[Polisemija (ili višeznačnost) je jedan od najproduktivnijih načina stvaranja novih značenja. Iako je univerzalna jezična pojava, višeznačnost polisemnih riječi može uzrokovati probleme u razumijevanju. Ipak, prirodni jezici koriste sposobnost kodiranja više značenja u jednom obliku u svoju korist. Ova je sklonost prirodnih jezika korisna jer smanjuje opterećenje pamćenja i učenja novih oblika (Piantadosi i sur. 2012). Budući da su metafora i metonimija jedni od najvažnijih mehanizama za stvaranje polisemije (Pustejovsky & Boguraev 1997; Bowdle i Gentner 2005), razumijevanje i usvajanje polisemnih riječi postaje još složenije zbog različitosti u dominantnosti i apstraktnosti značenja. Ljudska potreba za olakšavanjem komunikacije i smanjenjem kognitivnog opterećenja, kao i sveprisutnost polisemije u svakodnevnom jeziku, čine polisemiju važnim dijelom dječjeg jezika od samih početaka usvajanja jezika. Iako su neka istraživanja već provedena na ovu temu (npr. Dautriche i sur. 2016; Floyd i sur. 2020), detaljna saznanja o tome koji jezični čimbenici utječu na usvajanje i razumijevanje polisemičnih riječi još uvijek ne postoje. Ova je tema složena zbog međusobnih odnosa između jezičnih čimbenika poput broja značenja, tipova značenja, dominantnosti značenja te učestalosti riječi i značenja. Konvencionalnost značenja također igra važnu ulogu jer figurativnost značenja često ostaje neprepoznata. Međutim, konvencionalnost nije zajamčena, a nova značenja mogu se pojaviti u bilo kojem trenutku . Cilj je ovog projekta odgovoriti na pitanja o statusu spomenutih jezičnih čimbenika i ulozi koju oni imaju u usvajanju jezika i ranom razumijevanju jezika. Također, ovaj projekt nastoji doprinijeti jezičnoj raznolikosti u istraživanjima usvajanja jezika istraživanjem relativno nedavno prikupljenih korpusa hrvatskog jezika i prikupljanjem podataka od govornika hrvatskog jezika.]]></summary_hr><summary_en><![CDATA[Polysemy (i.e. words having multiple related meanings) is one of the most productive ways of creating new meanings. Despite being a language universal, the ambiguity of polysemous words can create issues in comprehension. Nevertheless, natural languages use the ability to encode more meanings in one form in their favour. This tendency seems to be advantageous since it lessens the burden of remembering and learning new forms (Piantadosi et al. 2012). Since the main generators of polysemy are metaphor and metonymy (Pustejovsky & Boguraev 1997; Bowdle i Gentner 2005), comprehension and acquisition of polysemous words become even more complex due to the variation in meanings’ dominance and abstractness. The human need to make communication effortless and to reduce cognitive load as well as the overwhelming presence of polysemy in everyday language, makes polysemy an important part of child language since the beginning of language acquisition. While there has been some research on this topic (e.g., Dautriche et al. 2016; Floyd et al. 2020), the details of which linguistic factors influence the acquisition and comprehension of polysemous words remain largely underresearched. This topic is complex due to the interactions between linguistic factors such as number of meanings, types of meanings, dominance of meanings and frequency of words and meanings. The conventionality of meanings also plays a role since the figurativeness of meanings is often not recognized. However, conventionality is not guaranteed and new meanings can emerge at any time. This project aims to answer questions regarding the status of the aforementioned linguistic factors and the role they play in language development and early language comprehension. Finally, the project aims to contribute to the cross-linguistic diversity of current language acquisition research by exploring fairly recently collected Croatian language corpora and collecting data from Croatian-speaking participants.  ]]></summary_en></project><project>
<id>18188</id><title_hr><![CDATA[Optimizacija uzgoja motra (Crithmum maritimum L.) uz praćenje biljnih odgovora i razvoj visokokvalitetnih ekstrakata inovativnim metodama ekstrakcije]]></title_hr><title_en><![CDATA[Optimization of Sea Fennel (Crithmum maritimum L.) Cultivation with Monitoring of Plant Responses and Development of High-Quality Extracts Using Innovative Extraction Methods]]></title_en><user_id>26541</user_id><user_firstLast_name>Maja Veršić Bratinčević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2025-02</proposal_call><code>UIP-2025-02-7919</code><acronim><![CDATA[SeaCRIME]]></acronim><duration>19.02.2026 - 18.02.2031</duration><status>U tijeku</status><financ_value>300.000,00 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Biotehnologija, Interdisciplinarne biotehničke znanosti, </scie_field_hr><scie_field_en>Biotechnology, Interdisciplinary biotechnical sciences, </scie_field_en><institution_hr><![CDATA[Institut za jadranske kulture i melioraciju krša]]></institution_hr><institution_en><![CDATA[Institute for Adriatic Crops and Karst Reclamation in Split]]></institution_en><team_members_id>23035, 868152, 865019, 13544, 13692, </team_members_id><team_members_names><![CDATA[Marijana Popović, Ana Vučak, Emanuel Gaši, Marko Runjić, Tonka Ninčević Runjić, ]]></team_members_names><keywords_hr><![CDATA[Optimizacija uzgoja, Abiotski stres, Molekularni odgovor, Zelene ekstrakcije, Visokokvalitetni ekstrakti motra, Inovativne formulacije]]></keywords_hr><keywords_en><![CDATA[Cultivation optimization, Abiotic stress, Molecular response, Green extractions, High-quality sea fennel extracts, Innovative formulations]]></keywords_en><summary_hr><![CDATA[Ubrzani stil života i neadekvatne prehrambene navike imaju negativan utjecaj na zdravlje, doprinoseći porastu incidencije kardiovaskularnih i metaboličkih bolesti, a također utječu i na zdravlje kože, ubrzavajući procese starenja i smanjujući opću vitalnost. Ovaj trend ističe potrebu za inovativnim pristupima u prevenciji i unapređenju zdravlja, a među ključnim rješenjima izdvajaju se proizvodi obogaćeni bioaktivnim spojevima koji nalaze široku primjenu u prehrambenoj, kozmetičkoj i farmaceutskoj industriji. Crithmum maritimum L. (motar) izdvaja se kao nutritivno i funkcionalno vrijedna samonikla mediteranska biljka, poznata po visokom sadržaju fitokemikalija. Međutim, ograničena dostupnost zbog prirodnog staništa i varijabilnost sastava predstavljaju izazove za širu primjenu ove biljke. Ovaj projekt ima za cilj optimizaciju uzgoja motra kao inovativnog pristupa osiguranju konzistentne kvalitete i povećanju akumulacije ciljanih bioaktivnih komponenti. Uzgoj pod uvjetima abiotskog stresa potaknut će sintezu željenih spojeva, dok će se prilagodbom uzgojnih uvjeta dodatno poboljšati nutritivni profil biljke. Implementacija zelenih metoda ekstrakcije omogućit će dobivanje visokokvalitetnih ekstrakata pogodnih za prehrambenu, kozmetičku ili farmaceutsku industriju. Dodatno, transkriptomske analize pridonijet će boljem razumijevanju molekularnih mehanizama sinteze bioaktivnih spojeva i odgovora biljke na abiotski stres. Projekt doprinosi očuvanju bioraznolikosti, poticanju lokalnog razvoja i razvoju inovativnih proizvoda s visokim potencijalom primjene u personaliziranoj brizi o zdravlju te održivoj i kružnoj prehrani.]]></summary_hr><summary_en><![CDATA[A fast-paced lifestyle and poor dietary habits negatively affect health, contribute to an increased incidence of cardiovascular and metabolic diseases, and also affect skin health, accelerate the aging process, and reduce overall vitality. This trend underscores the need for innovative approaches to health prevention and enhancement, including products enriched with bioactive compounds that have broad applications in the food, cosmetic, and pharmaceutical industries. Crithmum maritimum L. (sea fennel) is a nutritionally and functional valuable wild-growing Mediterranean plant, renowned for its high concentration of phytochemicals. However, its limited availability due to natural habitat constraints and variability in composition present challenges for its broader application. This project aims to optimize the cultivation of sea fennel as a novel approach to ensure consistent quality and increase the accumulation of targeted bioactive components. Cultivation under abiotic stress conditions will stimulate the synthesis of desired compounds, while the modulation of growing conditions will further enhance the plant&#39;s nutritional profile. The use of green extraction techniques will facilitate the production of high-quality extracts suitable for the food, cosmetic, and pharmaceutical industries. Additionally, transcriptomic analyses will provide deeper insights into the molecular mechanisms underlying the synthesis of bioactive compounds and the plant&#39;s response to abiotic stress. The project will contribute to the preservation of biodiversity, foster local development, and generate innovative products with significant potential in personalized health care and sustainable, circular nutrition]]></summary_en></project><project>
<id>18193</id><title_hr><![CDATA[Sveobuhvatna analiza teksture ploda masline: novi pristup poboljšanju kvalitete djevičanskog maslinova ulja]]></title_hr><title_en><![CDATA[A Comprehensive Fruit Texture Analysis: Novel approach to improve Virgin Olive Oil Quality]]></title_en><user_id>3466</user_id><user_firstLast_name>Maja Jukić Špika</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2025-02</proposal_call><code>UIP-2025-02-6625</code><acronim><![CDATA[OLIVIA]]></acronim><duration>01.04.2026 - 31.03.2031</duration><status>U tijeku</status><financ_value>298.670,00 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Prehrambena tehnologija, </scie_field_hr><scie_field_en>Food technology, </scie_field_en><institution_hr><![CDATA[Institut za jadranske kulture i melioraciju krša]]></institution_hr><institution_en><![CDATA[Institute for Adriatic Crops and Karst Reclamation in Split]]></institution_en><team_members_id>869796, 27117, 870168, 26025, 13471, </team_members_id><team_members_names><![CDATA[Natalija Bulaš, Josip Tadić, Jesus Exposito Torres, Nives Kević, Klara Kraljic, ]]></team_members_names><keywords_hr><![CDATA[plod masline, tekstura, djevičansko maslinovo ulje, prinos ulja, tehnologija prerade, endogeni enzimi, mljevenje, miješenje, inovativne tehnolgije]]></keywords_hr><keywords_en><![CDATA[olive fruit, texture, virgin olive oil, oil yield, technological processing, endogenous enzymes, milling, malaxation, innovative technologies]]></keywords_en><summary_hr><![CDATA[Ovaj projekt za cilj ima istražiti mogućnost korištenja teksturnih svojstava ploda masline kao novog dijagnostičkog alata za optimizaciju procesa prerade i poboljšanje kvalitete ekstra djevičanskog maslinova ulja. Motivacija za ovo istraživanje leži u činjenici da nedovoljno izdvajanje ulja i njegovo zaostajanje u komini  ostaje još uvijek ključni problem u preradi maslinova ulja. Uz to, zbog zakonskih ograničenja koja definiraju način dobivanja djevičanskog maslinova ulja (DMU), jedini način za unapređenje procesa jest optimizacija parametara prerade, razumijevanje uloge endogenih enzima i razvoj novih metoda analize fizikalno-kemijskih svojstava ploda.U okviru ovog projekta provest će se sveobuhvatna biokemijska i strukturna analiza ploda masline, uz uspostavu baze podataka o teksturnim svojstvima hrvatskih sorti masline. Istražit će se utjecaj dezintegracije tkiva ploda, primjene inovativnih tehnologija te uvjeta hlađenja ploda nakon berbe na aktivnost enzima odgovornih za izdvajanje ulja, koalescenciju kapljica ulja, viskoznost tijesta masline te fizikalna i nutritivna svojstva DMU. Poseban fokus biti će na reološkim svojstvima maslinova tijesta tijekom prerade, koja utječu na iskorištenje i kvalitetu dobivenog ulja.Novi pristup temelji se na pronalaženju poveznice između primarnih i sekundarnih metabolita, teksturnih svojstava ploda (elastičnost, tvrdoća, kohezivnost itd.), reoloških karakteristika tijesta tijekom prerade te konačne kemijske i organoleptičke kvalitete ulja. Projekt će koristiti integrirani pristup koji obuhvaća biološke, kemijske i tehnološke aspekte, stvarajući znanstveno utemeljene smjernice za učinkovitiju preradu. Rezultati istraživanja omogućiti će preciznije upravljanje proizvodnim procesom, čime će se osigurati veće iskorištenje sirovine uz očuvanje nutritivnih i organoleptičkih svojstava ekstra djevičanskog maslinova ulja.]]></summary_hr><summary_en><![CDATA[This project aims to investigate the potential use of the textural properties of olive fruit as a novel diagnostic tool to optimize the processing and improve the quality of extra virgin olive oil. The motivation for this research lies in the fact that insufficient oil extraction and retention of the oil in the pomace remains the key issue in olive oil processing. Furthermore, due to the legal restrictions that define the process for obtaining virgin olive oil (VOO), the only way to improve the process is: to optimize the processing parameters, understand the role of endogenous enzymes and develop new methods to measure the physicochemical characteristics of the fruit.Within this project, a comprehensive biochemical and structural analysis of olive fruit will be carried out and a database on the textural properties of Croatian olive cultivars will be created. The study will investigate the effects of disintegration of fruit tissue, application of innovative technologies and post-harvest cooling conditions on the activity of enzymes responsible for oil extraction, coalescence of oil droplets, viscosity of olive paste and physicochemical and nutritional properties of VOO. Particular attention will be paid to the rheological properties of the olive paste, which influence the oil yield and quality.This novel approach is based on the identification of the relationship between primary and secondary metabolites, the textural properties of the fruit (elasticity, hardness, cohesiveness, etc.), the rheological characteristics of the paste and the final chemical and organoleptic quality of the oil. The project will follow an integrated approach that includes biological, chemical and technological aspects and will provide scientifically based guidelines for more efficient processing. The results will allow more precise management of the production process and ensure higher raw material utilization while maintaining the nutritional and organoleptic properties of EVOO.]]></summary_en></project><project>
<id>18194</id><title_hr><![CDATA[Razvoj konceptualnog okvira rezilijentnosti malih i srednjih poduzeća korištenjem teorije efektuacije]]></title_hr><title_en><![CDATA[Developing a Conceptual Framework for SMEs&#39; Resilience Using Effectuation Theory]]></title_en><user_id>2825</user_id><user_firstLast_name>Nataša Šarlija</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-2518</code><acronim><![CDATA[RESET]]></acronim><duration>05.12.2025 - 04.12.2028</duration><status>U tijeku</status><financ_value>181.316,72 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, </scie_field_hr><scie_field_en>Economy, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Ekonomski fakultet u Osijeku]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Economics]]></institution_en><team_members_id>870735, 870892, 921, 6530, 870902, 866485, 865941, 866413, </team_members_id><team_members_names><![CDATA[Saras Sarasvathy, Lucia Walsh, Mirta Benšić, Slavica (Vjekoslava) Singer, Charles Plant, Dražen Novaković, Riillo Cesare, AUWAL ISAH, ]]></team_members_names><keywords_hr><![CDATA[rezilijentnost, efektuacija, mala i srednja poduzeća, održivost, poduzetništvo]]></keywords_hr><keywords_en><![CDATA[resilience, effectuation, small and medium enterprises, sustainability, entrepreneurship]]></keywords_en><summary_hr><![CDATA[Projekt Razvoj konceptualnog okvira rezilijentnosti malih i srednjih poduzeća korištenjem teorije efektuacije predstavlja kontinuiranost znanstveno-istraživačkog rada predlagateljice projekta koja je vodila i projekt Razvoj i primjena modela predikcije rasta za mala i srednja poduzeća u Hrvatskoj, financiran od HRZZ u razdoblju 2014-2018.   Rezilijentnost je sinergijski efekt isprepletenosti poslovnog zdravlja, sposobnosti predviđanja i organizacijske kulture temeljene na proaktivnosti i inovativnosti, odnosno na principima efektuacije.  Sinergijska karakteristika rezilijentnosti je u projektu definirana kroz koncept 5E: Entrepreneur (poduzetnik), Enterprise (poduzeće),   Employees (zaposlenici), Equity (financije), Environment (okolina). Korištenje teorije efektuacije u definiranju konceptualnog okvira rezilijentnosti znači da se naglašava kako se ograničenost resursa može rješavati suradnjom, odnosno umrežavanjem, uz korištenje principa efektuacije &#39;bird in hand&#39;, &#39;affordable loss&#39;, &#39;patchworking&#39;, &#39;pilot in the plane&#39; i &#39;crazy quilt&#39;. Rezilijentnost je pretpostavka održivosti poslovnog pothvata, te se poslovni modeli trebaju  graditi na razumijevanju UN ciljeva održivog razvoja i društvenih, ekonomskih i okolišnih implikacija koji proizlaze iz tih ciljeva, što će biti ugrađeno u razvoj konceptualnog okvira i modela rezilijentnosti malih i srednjih poduzeća. Istraživačka dinamika projekta počinje s teorijskom analizom rezilijentnosti malih i srednjih poduzeća, te se nakon provedbe empirijskog istraživanja i interpretacije prikupljenih podataka završava izradom konceptualnog okvira i modela rezilijentnosti. Empirijsko istraživanje će se provesti u pet zemalja: Hrvatska, Irska, Kanada, Njemačka i Nigerija, kako bi se dobio uvid je li i u kojoj mjeri razina dohotka po stanovniku (bogatstvo zemlje) utječe na rezilijentnost malih i srednjih poduzeća.]]></summary_hr><summary_en><![CDATA[The project &#39;&#39; Developing a Conceptual Framework for SMEs&#39; Resilience Using Effectuation Theory &#39;&#39; represents a continuation of the scientific research work of the project leader (Prof.dr.sc. Nataša Šarlija and her core team). She previously led the project &#39;&#39;Development and Application of Growth Prediction Models for SMEs in Croatia&#39;&#39;, funded by the Croatian Science Foundation (HRZZ) from 2014 to 2018.Resilience is a synergistic effect of the interconnectedness of business health, forecasting ability, and an organizational culture based on proactivity and innovation—aligned with the principles of effectuation. The project&#39;s definition of resilience as a synergy is structured through the 5E concept: Entrepreneur, Enterprise, Employees, Equity and Environment. Applying effectuation theory to define the conceptual framework for resilience emphasizes that resource constraints can be addressed through collaboration and networking, leveraging the principles of effectuation: bird in hand, affordable loss, patchworking, pilot in the plane, and crazy quilt. Resilience is a prerequisite for the sustainability of a business venture. Therefore, business models should be built on an understanding of the UN Sustainable Development Goals (SDGs) and the social, economic, and environmental implications arising from them—elements that will be incorporated into the development of the conceptual framework and resilience model for SMEs. The research dynamics of the project begin with a theoretical analysis of SME resilience. Following empirical research—based on both quantitative and qualitative data collection from entrepreneurs—and the interpretation of collected data, the project will conclude with the development of a conceptual framework and a resilience model. The empirical research will be conducted in five countries: Croatia, Ireland, Canada, Germany, and Nigeria, to examine whether and to what extent a country&#39;s income level (national wealth) influences SME resilience.]]></summary_en></project><project>
<id>18196</id><title_hr><![CDATA[Danube4 all ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>74</user_id><user_firstLast_name>Sandi Orlić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-1066</code><acronim><![CDATA[]]></acronim><duration>20.01.2026 - 19.01.2031</duration><status>U tijeku</status><financ_value>60,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>873077</team_members_id><team_members_names><![CDATA[ Doktorand: Kristina Delaš ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>18198</id><title_hr><![CDATA[Planiranje profitabilnog rada komponenti pametnog energetskog sustava u samodostatnoj energetskoj zajednici korištenjem metoda strojnog učenja]]></title_hr><title_en><![CDATA[Planning the profitable operation of smart energy system components in a self-sufficient energy community using machine learning methods]]></title_en><user_id>13333</user_id><user_firstLast_name>Goran Krajačić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-4220</code><acronim><![CDATA[Plan-Profit-EZ]]></acronim><duration>05.12.2025 - 04.12.2028</duration><status>U tijeku</status><financ_value>176.268,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, Elektrotehnika, Računarstvo, Temeljne tehničke znanosti, Interdisciplinarne tehničke znanosti, </scie_field_hr><scie_field_en>Mechnical engineering, Electrical engineering, Computer sciences, Basic engineering sciences, Interdisciplinary technological sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>870773, 870778, 867120, 873723, </team_members_id><team_members_names><![CDATA[Mario Mihetec, Goran Stunjek, Stanislav Boldyryev, Sunčan Vojvodić, ]]></team_members_names><keywords_hr><![CDATA[strojno učenje, IoT tehnologija, prediktivna analiza, baza podataka, pametni energetski sustav, energetska zajednica, korisnička aplikacija]]></keywords_hr><keywords_en><![CDATA[Machine learning, IoT technology, predictive analytics, database, smart energy system, energy community, user application]]></keywords_en><summary_hr><![CDATA[Istraživački projekt bavi se planiranjem profitabilnog rada komponenti pametnog energetskog sustava u samodostatnoj energetskoj zajednici korištenjem metoda strojnog učenja korištenjem stvarnih, povijesnih i prediktivnih podataka mjerenja. Sustav je raščlanjen na proizvodnju (solarni panel), potrošnju (podesivo DC opterećenje) i skladištenje električne energije (baterija). Korištenjem vremenskih podataka za proizvodnju električne energije te povijesnih podataka potrošnje, napravit će se model prediktivne proizvodnje i potrošnje. Uređaji povezani putem Interneta (IoT), mikrokontroleri i senzori, u samodostatnom energetskom sustavu mjerit će i prikupljati podatke u realnom vremenu u svrhu unaprijeđenja s već postojećim podacima korištenjem strojnog učenja. Krajnji korisnik sustava će imati uvid u svoje trenutne, prošle i prediktivne podatke putem aplikacije. Aplikacija će bit jednostavna za korištenje uz jednostavni UI/UX dizajn. Cilj projekta je korištenjem strojnog učenja predvidjeti proizvodnju i potrošnju te analizom podataka optimizirati upravljanje električnom energijom dan nakon.]]></summary_hr><summary_en><![CDATA[The research project focuses on planning the profitable operation of components in a smart energy system within a self-sufficient energy community using machine learning methods, utilizing real, historical, and predictive measurement data. The system is divided into production (solar panel), consumption (programmable DC load), and energy storage (battery). By using weather data for energy production and historical consumption data, a predictive model for production and consumption will be developed. Devices connected via the Internet (IoT), microcontrollers, and sensors in the self-sufficient energy system will measure and collect real-time data to improve the system with existing data through machine learning. The end user of the system will have access to their current, past, and predictive data via an application. The application will be easy to use with a simple UI/UX design. The goal of the project is to predict production and consumption using machine learning and, through data analysis, optimize the management of electrical energy for the following day.]]></summary_en></project><project>
<id>18202</id><title_hr><![CDATA[Razvoj učinkovitijih cjepiva temeljenih na citomegalovirusu: pojačavanje imuniteta sluznice ]]></title_hr><title_en><![CDATA[Designing better cytomegalovirus-based vaccines: boosting mucosal immunity]]></title_en><user_id>19184</user_id><user_firstLast_name>Maja Cokarić Brdovčak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2025-02</proposal_call><code>UIP-2025-02-5202</code><acronim><![CDATA[MUCO-CMV]]></acronim><duration>01.04.2026 - 31.03.2031</duration><status>U tijeku</status><financ_value>299.980,00 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Medicine]]></institution_en><team_members_id>25389, 865130, 868726, </team_members_id><team_members_names><![CDATA[Marko Šustić, Jelena Materljan Franki, Lucija Šakota, ]]></team_members_names><keywords_hr><![CDATA[citomegalovirus, cjepni vektor, respiratorni patogeni, imunost sluznice, stečena imunost, IgA protutijela, tkivno-rezidentne memorijske stanice]]></keywords_hr><keywords_en><![CDATA[cytomegalovirus, vaccine vector, respiratory pathogens, mucosal immunity, adaptive immunity, IgA antibodies, tissue-resident memory cells]]></keywords_en><summary_hr><![CDATA[Globalna pandemija bolesti COVID-19 naglasila je razoran utjecaj respiratornih patogena i istaknula potrebu za poboljšanjem postojećih strategija cijepljenja. Posebno je potaknula interes za uključivanje imunosti sluznice u dizajn cjepiva, zbog njene ključne uloge u prvoj liniji obrane od respiratornih infekcija. Sve veći broj istraživanja sugerira da mukozna cjepiva imaju potencijal izazvati snažni stanični i humoralni imunološki odgovor, koji ima sposobnost blokirati vezanje i ulazak patogena na epitelnim površinama. Jedan od potencijalnih pristupa za razvoj mukoznih cjepiva je korištenje virusa koji perzistiraju u tkivu sluznica i induciraju snažan i dugotrajan imuni odgovor na tim mjestima. Citomegalovirus (CMV), je široko rasprostranjen ß-herpesvirus koji uspostavlja doživotnu latentnu infekciju u svom domaćinu. CMV ima nekoliko karakteristika koje ga čine idealnim kandidatom za vektorska cjepiva, te su brojne pretkliničke studije pokazale potencijal korištenja CMV-a kao vektorskog cjepiva u različitim modelima infektivnih bolesti i tumorima.U ovom projektu cilj nam je: 1) Odrediti sposobnost vektora temeljenog na CMV-u da izazove antigen-specifični odgovor protutijela usmjeren na patogene u respiratornoj sluznici; 2) Identificirati faktore domaćina koji reguliraju izlučivanje IgA nakon imunizacije MCMV-om; 3) Istražiti virusne determinante koje utječu na izlučivanje IgA nakon cijepljenja; 4) Istražiti inovativne strategije dizajna vektora za razvoj mukoznih cjepiva, sposobnih za izazivanje snažne i dugotrajnije stečene imunosti. Sveukupno, ovo istraživanje pridonijet će boljem razumijevanju mehanizama koji pokreću zaštitnu imunost sluznice, što je ključni korak prema razvoju učinkovitijih cjepiva protiv širokog spektra respiratornih patogena.]]></summary_hr><summary_en><![CDATA[The global COVID-19 pandemic underscored the devastating impact of respiratory pathogens and highlighted the urgent need to improve current vaccination strategies. In particular, it prompted interest in incorporating mucosal immunity into vaccine design, due to its critical role in frontline defense against respiratory infections. Growing body of evidence suggests that mucosal vaccines have the potential to elicit robust cellular and humoral immune responses resulting in sterilizing immunity by blocking pathogen attachment and entry at epithelial surfaces. One of the approaches that could be exploited in the development of mucosal vaccines is the use of viruses that persist in the mucosal tissues and induce robust and long-lasting immune responses at these sites. Cytomegalovirus (CMV) is a ubiquitous ß-herpesvirus that establishes life-long latent infection in its host. CMV has several characteristics that make it an ideal vaccine vector and so far, numerous  preclinical studies have demonstrated the value of CMV as a vaccine vector in diverse infectious and cancer models. In this project, we aim to: (1) Evaluate the capacity of  CMV-based vector vaccine to elicit antigen-specific antibody responses against respiratory pathogens in the mucosal compartment; (2) identify host factors that regulate IgA secretion following MCMV immunization; (3) investigate viral determinants influencing IgA induction upon vaccination and (4) explore innovative vector engineering strategies to develop next-generation mucosal vaccines capable of eliciting potent and durable cellular and humoral immune responses. Altogether, this research will contribute to our understanding of mechanisms driving protective mucosal immunity, a key step toward the development of more effective vaccines against a broad spectrum of respiratory pathogens.]]></summary_en></project><project>
<id>18204</id><title_hr><![CDATA[Submisivna ponašanja: kognitivni i fiziološki mehanizmi, socijalna dinamika i psihološka dobrobit]]></title_hr><title_en><![CDATA[Submissive Behaviors: Cognitive and Physiological Mechanisms, Social Dynamics, and Psychological Well-being]]></title_en><user_id>868062</user_id><user_firstLast_name>Asmir Gračanin</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-1086</code><acronim><![CDATA[SubmitWell]]></acronim><duration>05.12.2025 - 04.12.2028</duration><status>U tijeku</status><financ_value>167.538,00 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Psihologija, </scie_field_hr><scie_field_en>Psychology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Filozofski fakultet u Rijeci]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>867799, 868088, 868354, 868125, 29097, 868301, 4038, 868187, 868317, 870090, 868403, </team_members_id><team_members_names><![CDATA[Petra Anić, Gorana Birovljević, Igor Kardum, Lorna Trdina, Karlo  Šimek, Karla Martičić Giljević, Zrinka Greblo Jurakić, Ad Vingerhoets, Drew Altschul, Adam Moore, Lauren Bylsma, ]]></team_members_names><keywords_hr><![CDATA[Submisivno ponašanje, Emocionalno plakanje,  Socijalne hijerarhije, Agresija, Dominacija, Ugled, Ličnost, Socijalna kognicija, Psihološka dobrobit]]></keywords_hr><keywords_en><![CDATA[Submissive Behavior, Emotional Crying, Social Hierarchies, Agression, Domination, Prestige, Personality, Social Cognition, Psychological Well-being]]></keywords_en><summary_hr><![CDATA[Submisivno ponašanje (SUP) se odnosi na skup obrambenih socijalnih strategija koje signaliziraju da se pojedinac odriče moći, statusa, autonomije ili kontrole. Njegova je funkcija održavanje društvene organizacije kroz smanjenje sukoba i poticanje pomirenja. SUP se može sagledavati i kao prolazno ponašanje i kao stabilna osobina pojedinca. Razumijevanje SUP-a ima implikacije za brojne socijalne procese i ishode u okvirima psihološke dobrobiti, poput agresije i anksioznosti s jedne strane te suradnje i zadovoljstva životom s druge. Glavni cilj ovog projekta je postići dublje razumijevanje kognitivnih, psihofizioloških i socijalnih mehanizama koji leže u osnovi SUP-a, kao i njegovih posljedica. Razvit ćemo i empirijski testirati model koji (a) definira različite vrste SUP-a kroz funkcionalnu analizu, (b) identificira uzroke i mehanizme svakog tipa SUP-a te (c) ispituje njihove posljedice. Model će se temeljiti na interakciji topline i kompetencije kao dvije glavne dimenzije socijalne percepcije. Najprije ćemo razviti model u kontekstu emocionalnog plakanja, oblika SUP-a koji naš istraživački tim proučava posljednjih desetak godina. Zatim ćemo ga proširiti na druge oblike SUP-a koji se mogu predvidjeti na temelju interakcije dimenzija topline i kompetencije. Razvoj modela bit će informiran spoznajama o različitim društvenim hijerarhijama koje se temelje na dominaciji i ugledu. Novi model bit će testiran pomoću (1) Eksperimenata usmjerenih na socijalnu kogniciju, vidljiva ponašanja i psihofiziološku podlogu različitih SUP-ova; (2) Psihometrijskog istraživanja stabilnih individualnih razlika u SUP-ovima; (3) Terenskog istraživanja unutar spontanih hijerarhija u formalnim grupama. Osim što će unaprijediti temeljno razumijevanje psiholoških osnova različitih oblika SUP-a, ovaj projekt generirat će nova saznanja o njihovim implikacijama za važne aspekte psihološke dobrobiti.]]></summary_hr><summary_en><![CDATA[Submissive behavior (SUB) refers to a set of social defensive strategies indicating an individual is relinquishing power, status, autonomy, or control. Its function is to promote social organization by reducing conflict and fostering reconciliation. SUB can be viewed both as a transient behavior and a stable interpersonal trait. Understanding SUB is crucial for gaining insight into multiple social and well-being outcomes, such as aggression and anxiety on one hand and collaboration and life satisfaction on the other. The main objective of this project is to gain a deeper understanding of the underlying cognitive, psychophysiological, and social mechanisms, as well as the consequences of different SUBs. We will develop and empirically test a model that (a) defines different types of SUB through functional analysis, (b) identifies the causes and mechanisms underlying each type of SUB, and (c) examines their consequences. This model will be based on the interaction between warmth and competence—two major dimensions of social perception. We will first develop the model in the context of emotional crying, a form of SUB our research team has studied over the past decade. We will then extend this model to other forms of SUB that fit within the warmth-competence framework. Model development will be informed by knowledge about different types of social rank hierarchies: dominance and prestige. The newly developed model will be tested through a series of empirical studies: (1) Experiments focusing on social cognition processes, observable behaviors, and psychophysiological concomitants of different SUBs; (2) Psychometric research examining stable individual differences in SUB; (3) Field studies within spontaneously emerging hierarchies in formal groups. Beyond advancing the basic understanding of the psychological underpinnings of SUB, this project will generate new knowledge about their implications for various aspects of psychological well-being.]]></summary_en></project><project>
<id>18208</id><title_hr><![CDATA[Indukcija i održivost VBNC stanja zoonotske Yersinia enterocolitica 4/O:3 u svinjskom mesu]]></title_hr><title_en><![CDATA[Induction and persistence of Viable but Non-Culturable (VBNC) Yersinia enterocolitica 4/O:3 in pork]]></title_en><user_id>25440</user_id><user_firstLast_name>Nevijo Zdolec</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-7300</code><acronim><![CDATA[sleepYE]]></acronim><duration>05.12.2025 - 04.12.2028</duration><status>U tijeku</status><financ_value>148.407,50 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Prehrambena tehnologija, Biotehnologija, </scie_field_hr><scie_field_en>Food technology, Biotechnology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Veterinarski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Veterinary Medicine]]></institution_en><team_members_id>26074, 868765, 870129, 1137, </team_members_id><team_members_names><![CDATA[Marta Kiš, Mladenka Vukšić, Vesna Mojčec Perko, Vladimir Farkaš, ]]></team_members_names><keywords_hr><![CDATA[Yersinia enterocolitica 4/O:3, žive a neuzgojive bakterije, svinjsko meso, mliječna kiselina, dekontaminacija ]]></keywords_hr><keywords_en><![CDATA[Yersinia enterocolitica 4/O:3, Viable but Non-Culturable bacteria, pork, lactic acid, decontamination]]></keywords_en><summary_hr><![CDATA[Dekontaminacija svinjskog mesa mliječnom kiselinom razmatra se kao krajnja mjera smanjivanja mikrobioloških rizika za potrošače. Yersinia enterocolitica 4/O:3 prioritetna je opasnost u proizvodnji svinjskog mesa, no učinak dekontaminacije odnosno sposobnost preživljavanja bakterije nedovoljno je poznat. To se posebno odnosi na fenomen prelaska bakterijskih stanica u VBNC stanje (engl. Viable but Non-Culturable; žive a neuzgojive bakterije) u nepovoljnim uvjetima. Stoga su ciljevi ovog projekta: I) Odrediti čimbenike i njihovu međuovisnost u indukciji i održivosti VBNC stanja sojeva Y. enterocolitica 4/O:3 primjenom mliječne kiseline in vitro; II) Odrediti markere (pokazatelje) VBNC stanja Y. enterocolitica 4/O:3 na proteomskoj razini; III) Istražiti prisutnost Y. enterocolitica 4/O:3 u VBNC stanju nakon dekontaminacije mesa mliječnom kiselinom, te IV) Istražiti održivost VBNC stanja Y. enterocolitica 4/O:3 u modificiranim uvjetima pohrane svinjskog mesa. U acidificiranim tekućim hranilištima i mesu odredit će se molekularnim putem (PMA-qPCR) udio neživih te živih a neuzgojivih stanica Y. enterocolitica 4/O:3, kao i razlike u proteomu tih populacija. Poseban doprinos istraživanja očekuje se i u razotkrivanju okidača vraćanja spavajućih stanica u fiziološko, patogeno stanje u uvjetima neadekvatne pohrane i rukovanja mesom. Rezultati ovog projekta mogu znatno doprinijeti znanstvenim spoznajama u području prehrambene tehnologije, higijene mesa i epidemiologije te pružiti smjernice za upravljanje skrivenim rizicima (VBNC) u prividno zdravstveno ispravnom mesu. ]]></summary_hr><summary_en><![CDATA[Decontamination of pork with lactic acid is considered the last control measure to reduce the microbiological risks for consumers. Yersinia enterocolitica 4/O:3 is a priority hazard in pork production, but the effect of decontamination or the survivability of the bacteria is poorly understood. This is especially true for the phenomenon that bacterial cells enter the VBNC (Viable but Non-Culturable) state  under unfavourable conditions. The aims of this project are therefore: I) to determine the factors and their interdependence in the induction and persistence of the VBNC state of Y. enterocolitica 4/O:3 strains using lactic acid in vitro; II) to determine markers (indicators) for the VBNC state of Y. enterocolitica 4/O:3 at the proteomic level; III) to investigate the presence of Y. enterocolitica 4/O:3 in the VBNC state after decontamination of meat with lactic acid and IV) to investigate the persistence of the VBNC state of Y. enterocolitica 4/O:3 under altered storage conditions of pork.In acidified broth and meat, the proportion of non-viable and live and non-culturable cells of Y. enterocolitica 4/O:3 will be determined by molecular means (PMA-qPCR) as well as the differences in the proteome of these populations. A particular contribution of the research is also expected from the identification of the trigger for the return of dormant cells to a physiological, pathogenic state under conditions of improper storage and handling of meat. The results of this project can make an important contribution to scientific knowledge in the field of food technology, meat hygiene and epidemiology and provide guidelines for hidden risks (VBNC) management in apparently safe meat.]]></summary_en></project><project>
<id>18212</id><title_hr><![CDATA[Agroforestry practices for Agroecological transition towards sustainable Sheep and Poultry farming in the Mediterranean region (ASPmed)]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3970</user_id><user_firstLast_name>Marija Cerjak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-2390</code><acronim><![CDATA[]]></acronim><duration>05.03.2026 - 04.03.2032</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Agronomski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Agriculture]]></institution_en><team_members_id>873120</team_members_id><team_members_names><![CDATA[ Doktorand: Tomica Marković ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>18213</id><title_hr><![CDATA[Testiranje teorijskih obašnjenja automatske teorije uma]]></title_hr><title_en><![CDATA[Testing theoretical accounts of automatic Theory of Mind]]></title_en><user_id>870219</user_id><user_firstLast_name>Edward Legg</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2025-02</proposal_call><code>UIP-2025-02-6677</code><acronim><![CDATA[AToM]]></acronim><duration>22.12.2025 - 21.12.2030</duration><status>U tijeku</status><financ_value>181.510,52 eur</financ_value><scie_area_hr>Interdisciplinarno područje znanosti</scie_area_hr><scie_area_en>Interdisciplinary scientific area</scie_area_en><scie_field_hr>Kognitivne znanosti, </scie_field_hr><scie_field_en>Cognitive Science, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Filozofski fakultet u Rijeci]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>24001, </team_members_id><team_members_names><![CDATA[Sandra Arbula, ]]></team_members_names><keywords_hr><![CDATA[Teorija uma, socijalna kognicija, očekivanje radnje, supresija alfa ritma, mentalizacija ]]></keywords_hr><keywords_en><![CDATA[Theory of Mind, Social Cognition, Action Expectation, alpha suppression, mentalising]]></keywords_en><summary_hr><![CDATA[Projekt će procjenjivati različita tumačenja o automatskoj Teoriji uma. Fokusirat ćemo se na nedovoljno istraženi aspekt tih teorija—očekivanje radnje. Kombinacijom bihevioralnih i neurofizioloških mjera, ispitat ćemo koje tumačenje najbolje objašnjava ulogu očekivanja radnje. ]]></summary_hr><summary_en><![CDATA[The project will evaluate different accounts of automatic Theory of Mind. We focus on an underresearched feature of these accounts– action expectation. Using a combination of behavioural and neurophysiological measures we will test which account best explains the role of action expectation. ]]></summary_en></project><project>
<id>18216</id><title_hr><![CDATA[Složene poplave u priobalnoj Hrvatskoj u sadašnjoj i budućoj klimi]]></title_hr><title_en><![CDATA[]]></title_en><user_id>22817</user_id><user_firstLast_name>Damjan Bujak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-3371</code><acronim><![CDATA[4C-Flood]]></acronim><duration>26.11.2025 - 25.11.2031</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Građevinarstvo, </scie_field_hr><scie_field_en>Civil engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Građevinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Civil Engineering]]></institution_en><team_members_id>872974</team_members_id><team_members_names><![CDATA[ Doktorand: Lovro Štefan ]]></team_members_names><keywords_hr><![CDATA[složene poplave, hidrauličko modeliranje, poplave mora, pluvijalne poplave, rizici od poplava, hidrologija, podizanje morske razine]]></keywords_hr><keywords_en><![CDATA[compound flooding, hydraulic modelling, coastal flooding, pluvial flooding, flood risk, hydrology, sea level rise]]></keywords_en><summary_hr><![CDATA[Priobalna područja su osjetljiva na poplave jer su izložena brojnim oceanografskim i hidrološkim događajima, kao što su olujni uspori, ekstremni valovi, visoki protoci rijeka i ekstremne oborine. Međutim, istodobna ili uzastopna pojava više različitih uzroka poplava može dovesti do znatno većih posljedica nego u slučaju njihovog zasebnog djelovanja. Takvi kombinirani događaji se općenito nazivaju složene poplave. Istraživanja provedena na globalnoj razini pokazuju da je najveća vjerojatnost složenih poplava u današnjoj klimi uglavnom koncentrirana duž Sredozemnog mora, a povijesne analize u Europi pokazuju da je najveći broj složenih događaja primijećen duž najsjevernije obale Jadranskog mora. Nažalost, u Hrvatskoj još uvijek nema studija o složenim poplavama, niti na nacionalnoj niti na lokalnoj razini. Ovaj će projekt okupiti znanstvenike iz različitih institucija u Hrvatskoj i inozemstvu s posebnim stručnim znanjem kako bi kvantificirali sadašnji i budući potencijal složenih poplava duž hrvatske obale, analizirali i kartirali opasnosti od složenih poplava na odabranim (posebno ranjivim) pilot područjima u Hrvatskoj i unaprijedili razumijevanje složenih poplava. Neposredni učinak ovog projekta su karte potencijala složenih poplava za hrvatsku obalu i karte opasnosti od složenih poplava za tri pilot područja te inovativni metodološki okvir. Konačni učinak ovog projekta na društvo i gospodarstvo bit će podizanje svijesti, smanjenje ekonomskih i ljudskih gubitaka te jačanje otpornosti priobalnih zajednica na složene poplave.]]></summary_hr><summary_en><![CDATA[Coastal regions are vulnerable to flooding because they are exposed to numerous oceanographic and hydrologic events, such as storm surges, extreme waves, high river flows, and extreme precipitation. However, the consequences of flooding caused by simultaneous or successive floods from different sources are greater than if the floods from these sources had occurred separately. Such combined events are referred to as compound flooding. Global studies indicate that the highest probability of compound flooding in the current climate is mainly concentrated along the Mediterranean Sea, and historical analyses in Europe show that the highest number of compound events was observed along the northernmost coast of the Adriatic Sea. Unfortunately, there are still no studies on compound flooding in Croatia, neither on national nor on local level. This project will bring together scientists from different institutions in Croatia and abroad with specific expertise to quantify the current and future compound flooding potential along the Croatian coast, analyse and map compound flooding hazards in selected pilot areas (particularly vulnerable) in Croatia and increase the general knowledge about the mechanisms of compound flooding. The immediate impact of this project are compound flood potential maps for the Croatian coast, compound flood hazard maps for three pilot areas, and an innovative methodological framework. The ultimate impact of this project proposal on society and the economy will be to raise awareness, reduce economic and human losses, and strengthen the resilience of coastal communities to compound flooding.]]></summary_en></project><project>
<id>18220</id><title_hr><![CDATA[Hrvatska moderna antiratna književnost]]></title_hr><title_en><![CDATA[Modern Croatian anti-War Literature]]></title_en><user_id>19189</user_id><user_firstLast_name>Zvonimir Glavaš</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2025-02</proposal_call><code>UIP-2025-02-6690</code><acronim><![CDATA[ARKa]]></acronim><duration>19.02.2026 - 18.02.2031</duration><status>U tijeku</status><financ_value>224.716,00 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filologija, </scie_field_hr><scie_field_en>Philology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>865796, 870339, 12494, 861752, </team_members_id><team_members_names><![CDATA[Karlo Držaić, Ivana Buljubašić Srb, Gabrijela Puljić, Pavle Bonča, ]]></team_members_names><keywords_hr><![CDATA[ratna književnost, antiratna književnost, politika književnosti, etika književnosti, sjećanje, svjedočenje, trauma]]></keywords_hr><keywords_en><![CDATA[war literature, anti-war literature, politics of literature, ethics of literature, memory, testimony, trauma]]></keywords_en><summary_hr><![CDATA[Projektom Hrvatska moderna antiratna književnost postavit će se temelji sustavnom, višeperspektivnom i metodološki suvremenom istraživanju hrvatske antiratne književnosti u njezinom širem diskurzivnom i povijesnom okruženju, koje će prvi put udružiti iscrpan pregled relevantne literature sa suvremenim teorijsko-metodološkim okvirom primijenjenim na reprezentativnom književnom korpusu te arhivskim istraživanjima prethodno neobrađene građe. Potaknuti suvremenim povijesnim kontekstom u kojem takva istraživačka pitanja ubrzano postaju sve važnija, članovi istraživačke skupine odlučili su reagirati na kroničnu zanemarenost sustavnog proučavanja antiratne književnosti te svojim istraživanjem osigurati pretpostavke njezinoj revalorizaciji i repozicioniranju u književnopovijesnom i književnokritičkhom polju. Istraživanje će se usredotočiti na tri tematska čvorišta – dva svjetska rata i Domovinski rat – te će antiratnoj književnosti pristupiti kao žanrovskom i društvenom fenomenu; baveći se njezinim strukturnim značajkama, ali i političkim i etičkim učincima, ulogom u njegovanju kulture sjećanja, artikulaciji svjedočenja i traume, izgradnji zajedničkih vrijednosti, oblikovanju antiratne svijesti i otpora ratohuškačkim ideologijama te totalitarnim praksama. Pritom će se interdisciplinarnim pristupom nadrasti tendencije historicističkog pozitivizma i heteroklitnih nizanja tematoloških prikaza koje su prevladavale u ranijem bavljenju antiratnom književnosti u hrvatskoj i međunarodnoj književnoznanstvenoj zajednici. Time će istraživanje dobiti odliku inovativnosti ne samo u hrvatskim, nego i širim međunarodnim okvirima. Konačno, važan aspekt projekta, s obzirom na svijest o društvenoj važnosti tematike kojom se zaokuplja, bit će i diseminacija kako u stručnoj javnosti, tako i u širim društvenim skupinama poput obrazovnih radnika i neprofesionalnih čitatelja.]]></summary_hr><summary_en><![CDATA[The project Modern Croatian anti-War Literature lays the foundation for a systematic, methodologically contemporary and multi-perspective study of modern Croatian anti-war literature in its discursive and historical context, combining for the first time a comprehensive overview of the relevant foreign literature with a contemporary theoretical and methodological framework applied to a representative literary corpus and archival research of previously unexplored material. Motivated by the current historical situation, in which such research questions are rapidly gaining relevance, the members of the research team have decided to respond to the chronic neglect of the systematic academic study of anti-war literature and to create the prerequisites for its reassessment and repositioning in the fields of literary history and literary criticism. The research will focus on three thematic nodes – two world wars and the Homeland War – and will address anti-war literature as a literary genre and social phenomenon, i.e. its structural features, but also its political and ethical implications; its role in promoting the culture of memory, the articulation of testimony and trauma, the formation of shared values, the development of anti-war consciousness and resistance to warmongering ideologies and totalitarian practices. In doing so, the research will overcome the historicizing positivism and heteroclitic sequences of thematic overviews that prevailed in earlier approaches to anti-war literature in both the Croatian and international scholarly communities. This makes the research innovative not only in Croatia, but also in the international context. As we are aware of the social significance of the issues we are dealing with, an important aspect of the project will be dissemination that is not limited to a professional audience, but also reaches broader social groups such as practitioners in education or non-professional readers.]]></summary_en></project><project>
<id>18222</id><title_hr><![CDATA[Kompleksni intermetalni Yb-spojevi pod tlakom i u jakim magnetskim poljima]]></title_hr><title_en><![CDATA[Complex intermetallic Yb-compounds under pressure and high magnetic field]]></title_en><user_id>25109</user_id><user_firstLast_name>Yuki Utsumi Boucher</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-7384</code><acronim><![CDATA[crYptid]]></acronim><duration>22.12.2025 - 21.12.2028</duration><status>U tijeku</status><financ_value>200.000,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, Kemija, Interdisciplinarne prirodne znanosti, </scie_field_hr><scie_field_en>Physics, Chemistry, Interdisciplinary natural sciences, </scie_field_en><institution_hr><![CDATA[Institut za fiziku]]></institution_hr><institution_en><![CDATA[Institute of Physics in Zagreb]]></institution_en><team_members_id>3247, 865280, 865337, 28955, 12358, 870660, </team_members_id><team_members_names><![CDATA[Petar Popčević, Seyed Ashkan Moghadam Ziabari, Gaurav Pransu, Veljko Zlatić, Damir Starešinić, Roman Gumeniuk, ]]></team_members_names><keywords_hr><![CDATA[Yb-spojevi, tlak, supravodljivost, magnetski fazni prijelaz, elektronska struktura]]></keywords_hr><keywords_en><![CDATA[Yb-compounds, pressure, superconductivity, magnetic phase transition, electronic structure ]]></keywords_en><summary_hr><![CDATA[Yb-spojevi s kubičnom strukturom tipa Yb3Rh4Sn13 i njihove varijante nazivaju se Remeika faze. Struktura sadrži ikozaedarske kaveze popunjene atomima Sn (ili Ge) i uključuje različite vrste kemijskih veza. Iako su Yb-spojevi Remeika  faza poznati desetljećima, njihova složena struktura i nedovoljna kvaliteta kristala rezultirali su njihovom neistraženošću. Najnovije studije koje koriste visokokvalitetne kristale počele su otkrivati  različite fenomene u ovim sustavima, kao što su teški fermioni, miješana Yb-valencija, efekt “zveckanja” i supravodljivost. U svim stanitima Yb3T4Sn13 (T: prijelazni metal) se pojavljuje supravodljivost . Među njima, Yb3Rh4Sn13 ima najviši Tc~8 K i pretpostavlja se da je supravodič s dva procjepa što je rezultat složene Fermijeve površine, koju tek treba istražiti. S druge strane, germanid Yb3Ir4Ge13 pokazuje antiferomagnetsko uređenje ispod 1 K s ogromnim povećanjem elektronske mase. Djelomična zamjena Ir s Rh uzrokuje prijelaz iz antiferomagnetskog stanja teških fermiona u stanje miješane valencije Yb. Ipak, činjenica da se radi o kemijskoj supstituciji potiče zabrinutost zbog postojanja nereda u kristalnoj strukturi. U ovom projektu, cilj nam je proučavati promjene valencije Yb, magnetske faze i supravodljive prijelaze Remeika faza Yb-spojeva i njihovih varijanti koristeći visokokvalitetne kristale. Korištenjem komplementarnih eksperimentalnih tehnika, električnih/magnetskih mjerenja, rendgenske spektroskopije i rendgenske difrakcije, planiramo detaljno mapirati fazne dijagrame Remeika faze Yb-spojeva u ovisnosti o tlaku, temperature i magnetskom polju. Razumijevanje promjene valencije Yb s tlakom, njegov utjecaj na magnetske fazne prijelaze elektronske i kristalne strukture te veza s pojavom supravodljivosti dat će nam smjernice za kontrolu osnovnog stanja Yb spojeva. Rezultati projekta mogli bi dovesti do primjene spojeva Remeika faza u termoelektričnim uređajima te za adijabatsko demagnetizirajuće hlađenje. ]]></summary_hr><summary_en><![CDATA[The Yb-compounds with the cubic Yb3Rh4Sn13-type structure and their variants are called Remeika phase compounds. The structure contains icosahedral cages with a filler atom and different types of chemical bonds. Although the Remeika phase Yb-compounds have been known for decades, their complex structure and insufficient crystal quality left them unexplored. Latest studies using high-quality crystals have started to uncover their various phenomena, such as heavy fermion behavior, intermediate Yb-valence, rattling effect, and superconductivity. All stannites Yb3T4Sn13 (T: transition metal) are reported to exhibit superconductivity. Yb3Rh4Sn13 has the highest Tc~8 K among them and is suggested to be a two-gap superconductor originating from its complex Fermi surface, which remains to be investigated. Germanide Yb3Ir4Ge13 exhibits antiferromagnetic ordering below 1 K with huge electron mass enhancement.  Partial substitution of Ir with Rh causes a cross-over from antiferromagnetic heavy fermion to intermediate Yb valence states. Yet, chemical substitution left a concern about lattice disorders. In this project, we aim to study pressure/magnetic field-driven Yb valence, magnetic phase, and superconducting to non-superconducting transitions of the Remeika phase Yb-compounds and their variants using high-quality crystals. By using complemental experimental techniques, electrical/magnetic measurements, x-ray spectroscopies, and x-ray diffraction, we expect to map out pressure, temperature, and field phase diagram of Remeika phase Yb-compounds. Understanding the pressure behavior of Yb valence and its role in the magnetic phase transition and electronic and crystal structures related to the emergence of superconductivity will give us guidance to control the ground state of Yb compounds.  The project results might pave the way for application of the Remeika phase compounds for thermoelectric devices and adiabatic demagnetizing refrigeration. ]]></summary_en></project><project>
<id>18225</id><title_hr><![CDATA[Novi dijagnostički biomarker za rakove mokraćnog sustava]]></title_hr><title_en><![CDATA[Novel diagnostic biomarker for urinary tract cancers]]></title_en><user_id>5308</user_id><user_firstLast_name>Damir Đermić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-5216</code><acronim><![CDATA[MarkUriCanc]]></acronim><duration>31.01.2026 - 30.01.2029</duration><status>U tijeku</status><financ_value>199.977,50 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>559, 183, 12366, 861750, 3990, 870838, </team_members_id><team_members_names><![CDATA[Isidoro Feliciello, Đurđica Ugarković, Siniša Ivanković, Sven Ljubić, Tvrtko Hudolin, Francesco Passaro, ]]></team_members_names><keywords_hr><![CDATA[karcinom mokraćnog mjehura, alfa satelitska DNA, rakovi mokraćnog sustava,  biomarker, plazma i urin]]></keywords_hr><keywords_en><![CDATA[bladder cancer, alpha satellite DNA, urinary tract cancers, biomarker, plasma and urine]]></keywords_en><summary_hr><![CDATA[Iako je rak mokraćnog mjehura (BC) uobičajena urološka bolest, metode koje se koriste za njegovo otkrivanje su nedostatne, posebno nedostaju one neinvazivne. Nedavno smo otkrili novi biomarker, alfa satelitsku DNA prisutnu u cirkulaciji izvan stanica (ccf), koji omogućuje pravovremenu i učinkovitu dijagnozu BC-a iz plazme pacijenata (bili su uglavnom iz Italije). Alfa satelitska DNA je glavna ljudska satelitska DNA za koju se pretpostavlja aberantna prekomjerna ekspresija u raku i povećano otpuštanje u cirkulaciju. Unutar predloženog projekta, koristeći osjetljivi digitalni PCR, planiramo proširiti naše istraživanje biomarkera na sljedeće načine: 1) korištenjem naše uspostavljene procedure na plazmi pacijenata s BC-om i zdravih kontrolnih skupina, pojačati uvjerljivost ccf satelitske DNA kao pouzdanog biomarkera za dijagnozu BC-a, a uz to ćemo procijeniti moguću univerzalnost biomarkera provjerom njegove primjenjivosti za hrvatsku populaciju, uz talijansku. 2) uspostaviti postupak za određivanje ccf satelitske DNA u urinu pacijenata s BC-om, kao i kod zdravih kontrola, te tako utvrditi može li urin poslužiti kao pouzdan izvor uzorka za ccf alfa satelitsku DNA, tj. za  biomarker. 3) procijeniti može li se ccf alfa satelitska DNA koristiti kao pouzdani biomarker za ranu dijagnozu drugih vrsta tumora mokraćnog sustava (kao što su rak bubrega, prostate...). 4) pratiti razine biomarkera ccf alfa satelitske DNA kod pacijenata s BC-om koji prolaze terapijski postupak kako bi se procijenila korisnost biomarkera u praćenju tijeka terapije. Predloženi projekt će karakterizirati dijagnostički biomarker, ccf alfa satelitsku DNA, na mnogo dublji i širi način, što bi olakšalo njegovu translaciju u kliničku medicinsku praksu.]]></summary_hr><summary_en><![CDATA[Although bladder cancer (BC) is a common urological disease, there are deficiencies of current methods used for its detection, especially the non-invasive ones are missing. We have recently discovered a novel biomarker, circulating cellular-free (ccf) alpha satellite DNA, that enables timely and efficient diagnosis of BC from the plasma of the patients (mostly from Italy). Alpha satellite DNA is a major human satellite DNA whose aberrant overexpression in cancers and increased release into the circulation is proposed. Within the proposed project, using sensitive digital PCR, we plan to expand on our biomarker research by: 1) using our established procedure on plasma from BC patients and healthy control cohorts, make more solid the case of ccf satellite DNA as a reliable biomarker for BC diagnosis, while assessing the possible universality of the biomarker by checking its applicability for the Croatian population, in addition to the Italian. 2) establish the procedure for determining ccf satellite DNA in urine from the BC patients as well as from the healthy control, and consequently establish whether urine can serve as a reliable sample source for ccf alpha satellite DNA biomarker. 3) assess whether ccf alpha satellite DNA can be employed as a reliable biomarker for early diagnosis of other types of urinary tract tumors (such as kidney, prostate etc.) 4) follow the ccf alpha satellite DNA biomarker’s levels in BC patients undergoing therapeutic procedure to evaluate the usefulness of the biomarker in assessing the course of therapy.  The proposed project will characterize the ccf alpha satellite DNA biomarker in a much deeper and broader manner, which would facilitate its translation into clinical medical practice. ]]></summary_en></project><project>
<id>18227</id><title_hr><![CDATA[Autonomni agenti u protokolima raspodijeljenih glavnih knjiga]]></title_hr><title_en><![CDATA[Autonomous Agents in Distributed Ledger Technologies Protocols]]></title_en><user_id>4568</user_id><user_firstLast_name>Matija Piškorec</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2025-02</proposal_call><code>UIP-2025-02-7498</code><acronim><![CDATA[AGENTS]]></acronim><duration>19.02.2026 - 18.02.2031</duration><status>U tijeku</status><financ_value>284.300,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>4718, </team_members_id><team_members_names><![CDATA[Damir Korenčić, ]]></team_members_names><keywords_hr><![CDATA[autonomni agenti, raspodijeljene glavne knjige, veliki jezični modeli, strojno učenje, kompleksne mreže]]></keywords_hr><keywords_en><![CDATA[autonomous agents, distributed ledger technologies, large language models, machine learning, complex networks]]></keywords_en><summary_hr><![CDATA[Tehnologija raspodijeljenih glavnih knjiga (DLT) ubrzano se razvija, s primjenama u međunarodnim plaćanjima i decentraliziranim financijama (DeFi) i društvenim mrežama. Istovremeno, sustavi umjetne inteligencije (AI) temeljeni na velikim jezičnim modelima (LLM) omogućuju napredne autonomne agente koji su mnogo moćniji od tradicionalnih botova. Dok je aktivnost botova na društvenim mrežama već proučavana, interakcija autonomnih agenata s DLT protokolima novije je istraživačko područje. Otvorena priroda DLT tehnologija omogućuje tim agentima sudjelovanje u online ekonomskim aktivnostima, zaobilazeći tradicionalna financijska ograničenja. Već sada većina transakcija stablecoinova provodi se od strane botova, a očekuje se daljnji nastavak tog trenda. Nadalje, decentralizirane društvene mreže poput Farcastera omogućuju ovim agentima integraciju u online društvene mreže.  Cilj ovog projekta je analizirati ekosustav autonomnih agenata u DLT tehnologijama. Fokus je na uspostavi infrastrukture za prikupljanje podataka, razvoju analitičkih metoda i karakterizaciji aktivnosti agenata unutar DLT protokola. Makroanaliza će se baviti strukturnim svojstvima interakcije agenata, dok će mikroanalize istraživati ponašanje pojedinačnih agenata. Strojno učenje, uključujući nadziranu klasifikaciju i zaključivanje temeljeno na LLM-ovima, pomoći će u predviđanju značajki poput potencijalno zlonamjernih aktivnosti. Osim toga, tim će implementirati autonomnog agenta na DLT platformi kako bi proučio njegovo ponašanje i utjecaj.  Istraživačka skupina na Institutu Ruđer Bošković uključuje dr. Matiju Piškorca kao glavnog istraživača, dr. Damira Korenčića kao suradnika na projektu, jednog višeg asistenta i jednog asistenta. Projekt će se provoditi u suradnji s Blockchain and Distributed Ledger Technologies (BDLT) grupom na Sveučilištu u Zurichu koju vodi prof. Claudio Tessone, s kojim dr. Piškorec ima višegodišnju suradnju.]]></summary_hr><summary_en><![CDATA[Distributed ledger technologies (DLT) are evolving rapidly, with applications in international payments (stablecoins) and decentralized finance (DeFi) and social networks. Simultaneously, artificial intelligence (AI) systems based on Large Language Models (LLMs) are enabling advanced autonomous agents that are much more powerful than traditional bots. While bot activity in social media has been studied previously, the interaction of autonomous agents with DLT protocols is a newer field. The permissionless nature of DLTs allows these agents to engage in online economic activity, bypassing traditional financial restrictions. Already a majority of stablecoin transactions are executed by bots, and this trend is expected to continue. Moreover, decentralized social media platforms like Farcaster allow these agents to integrate into online social networks.This project aims to analyze the emerging ecosystem of autonomous agents in DLT technologies. It focuses on establishing data collection infrastructure, developing analytical methods, and characterizing agent activity across DLT protocols. Macro-level analysis will involve structural properties of agent interaction, while micro-level studies will assess individual agent behavior. Machine learning, including supervised classification and LLM-based reasoning, will help predict features such as potential malicious activity. Additionally, the team will deploy an autonomous agent on a DLT platform to study its behavior and impact.The research group at the Rudjer Boskovic Institute includes Dr. Matija Piškorec as principal investigator, Dr. Damir Korenčić as project associate, a postdoctoral researcher, and a PhD student. The project will be conducted in collaboration with the Blockchain and Distributed Ledger Technologies (BDLT) group at the University of Zurich, led by Prof. Claudio Tessone, with whom Dr. Piškorec has an ongoing collaboration.]]></summary_en></project><project>
<id>18231</id><title_hr><![CDATA[Ekscitonska konfiguracijska interakcija: ususret generalnoj i efikasnoj ab-initio metodi elektronske strukture za multikromoforne sustave]]></title_hr><title_en><![CDATA[Excitonic Configuration Interaction: Towards a General and Efficient Ab-Initio Method for Multichromophoric Systems]]></title_en><user_id>25276</user_id><user_firstLast_name>Tomislav Piteša</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2025-02</proposal_call><code>UIP-2025-02-1368</code><acronim><![CDATA[ECI2GAME]]></acronim><duration>01.04.2026 - 31.03.2031</duration><status>U tijeku</status><financ_value>226.675,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>870711, </team_members_id><team_members_names><![CDATA[Sebastian Mai, ]]></team_members_names><keywords_hr><![CDATA[Molekulski ekscitoni, neadijabatska dinamika, multikromoforni sustavi, fotokemija molekule DNA, prijenos naboja]]></keywords_hr><keywords_en><![CDATA[Molecular excitons, nonadiabatic dynamics, multichromophoric systems, photochemistry of DNA, charge transfer]]></keywords_en><summary_hr><![CDATA[Pobuđena elektronska stanja malih molekula mogu se učinkovito računati konvencionalnim kvantno-kemijskim metodama kao što su CIS/TD-DFT, MPn/ADC(n), EOM-CC i CASSCF/CASTP2. Međutim, ove metode nepovoljno skaliraju s veličinom sustava, čineći izračune neizvedivim za velike multikromoforne sustave. Ovo se ograničenje može prevladati uporabom ekscitonskih modela, gdje se stanja pojedinačnih kromofora (site stanja) računaju konvencionalno, a zatim se koriste za konstrukciju jednostavnog ekscitonskog hamiltonijana cijelog sustava.Projekt ECI2GAME ima za cilj razviti generalnu i učinkovitu metodu elektronske strukture za multikromoforne sustave temeljenu na nedavno uvedenom konceptu ekscitonske konfiguracijske interakcije (ECI). Rezultirajuća ECI metoda će (i) imati približno linearno skaliranje s brojem kromofora uz minimalnu grešku u usporedbi s konvencionalnim metodama; (ii) tretirati stanja proizvoljnog multikromofornog karaktera, kao što su (multi)lokalne pobude, stanja s (višestrukim) prijenosom naboja, njihove kombinacije, itd.; (iii) biti neovisna o konvencionalnoj metodi koja se koristi u izračunima site stanja, dopuštajući korištenje različitih tipova site stanja; i (iv) moći tretirati sustave s umjereno jako interagirajućim kromoforima.Metodologija će biti implementirana u paketu SHARC, fokusiranom na surface-hopping simulacije molekulske neadijabatske dinamike. Stoga će, nakon što se razvije, ECI metoda omogućiti i simulacije fotoinduciranih procesa u multikromofornim sustavima u realnom vremenu, kao što su Försterov/Dexterov prijenos energije, singletna fisija, prijenos naboja itd.Pristup će se primijeniti na proučavanje fotokemije segmenata ljudske DNA koji su najskloniji oštećenjima izazvanim UV zračenjem. Ovo će razjasniti procese koji se događaju u prvih nekoliko pikosekundi nakon UV apsorpcije, a koji utječu na sudbinu DNA na dugim vremenskim skalama. Planirana su i dodatna fotokemijska istraživanja na drugim relevantnim multikromofornim sustavima.]]></summary_hr><summary_en><![CDATA[Excited electronic states of small molecules can be efficiently calculated with conventional quantum-chemistry methods like CIS/TD-DFT, MPn/ADC(n), EOM-CC, and CASSCF/CASTP2. However, these methods scale unfavorably with system size, making the calculations unfeasible for large multichromophoric systems. This limitation can be overcome by using an exciton model, where the states of individual chromophores (site states) are computed conventionally, and then used to construct a simple exciton Hamiltonian of the full system.The ECI2GAME project aims to develop a general and efficient electronic-structure method for multichromophoric systems based on the recently introduced Excitonic Configuration Interaction (ECI) concept. The resulting ECI method will (i) have near-linear scaling with the number of chromophores, with minimal error compared to conventional methods; (ii) handle states of arbitrary multichromophoric character, such as (multi)local excitations, (multi-)charge-transfer states, their combinations, etc.; (iii) be independent of the conventional method used in site-state calculations, allowing usage of diverse types of the site states; and (iv) be able to treat the systems with moderately strongly interacting chromophores.The methodology will be implemented in the SHARC package, which focuses on surface-hopping simulations of molecular nonadiabatic dynamics. Hence, once developed, the ECI method will also enable real-time simulations of photoinduced processes in multichromophoric systems, such as Förster/Dexter energy transfer, singlet fission, charge transfer, etc.The approach will be applied to study the photochemistry of human DNA segments most prone to UV-induced damage. This will elucidate the processes happening in the first few picoseconds after the UV absorption that influence the fate of the DNA on the long timescales. Additional photochemical studies on other relevant multichromophoric systems are also planned.]]></summary_en></project><project>
<id>18244</id><title_hr><![CDATA[Napredni poluvodički elementi u graničnim područjima upotrebe]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6955</user_id><user_firstLast_name>Tomislav Suligoj</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-1561</code><acronim><![CDATA[SemiLimit]]></acronim><duration>12.11.2025 - 11.11.2031</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>872917</team_members_id><team_members_names><![CDATA[ Doktorand: Paula Bartulović ]]></team_members_names><keywords_hr><![CDATA[Poluvodički elektronički elementi, HCBT, CMOS tehnologija, fotodetektor, SPAD, amorfni bor, niskotemperaturna elektronika, sigurno područje rada ]]></keywords_hr><keywords_en><![CDATA[Semiconductor devices, HCBT, CMOS technology, photodetector, SPAD, amorphous boron, low-temperature electronics, safe operating area]]></keywords_en><summary_hr><![CDATA[Cilj predloženog projekta je istražiti svojstva naprednih poluvodičkih elektroničkih elemenata na granicama njihovih karakteristika te izvan konvencionalnih radnih okruženja, omogućujući potpuno iskorištavanje njihovog potencijala i/ili proširenje područja primjene. Demonstrirat će se rad bipolarnog tranzistora s horizontalnim tokom struje (HCBT) na granici i izvan linearnog područja rada (LOA) i RF sigurnog područja rada (RF SOA), posebno u režimu visokih napona (iznad proboja), visokih struja i visoke RF snage, te će se povezati s tehnološkim parametrima. Niskotemperaturnom karakterizacijom HCBT-a dobit će se slika o potencijalu jednostavne, silicijske, CMOS-kompatibilne tehnologije za kriogene primjene poput kvantnih računala, uzimajući u obzir sve relevantne fizikalne efekte.Nove strukture lavinskih fotodioda za detekciju jednog fotona (SPAD) bit će projektirane u visokonaponskoj HV CMOS tehnologiji s ciljem optimiranja efikasnosti detekcije i smanjenja šuma. Izmjerene karakteristike procesiranih SPAD-ova koristit će se za procjenu utjecaja tehnoloških parametara na njihove električke i optičke karakteristike. Projektirat će se 2D matrica SPAD-ova zajedno s pripadajućim sklopovima za očitavanje te će se posebno optimirati za brzinu odziva i minimalnu površinu pogodnu za ekstremne uvjete rada. SPAD-ovi i matrice će također biti procesirane u skaliranoj CMOS tehnologiji, što će rezultirati detaljnom usporedbom dvaju tehnoloških čvorova.Detaljno će se okarakterizirati duboki defekti na svim granicama materijala u Pure(Ga)B diodama koji su ključni za njihova električka i optička svojstva u stacionarnoj, AC i tranzijentnoj domeni od sobne do kriogenih temperatura. Opisat će se i temperaturne ovisnosti vertikalnog i lateralnog vođenja struje u PureB i PureGaB slojevima na različitim podlogama (Si, SiGe, Ge). Razvit će se skalabilni 2D model diode u širokom temperaturnom području.]]></summary_hr><summary_en><![CDATA[The goal of the proposed project is to explore the properties of advanced semiconductor devices at the limits of their characteristics and beyond conventional working environments, enabling full utilization of their potential and/or widening their application spectrum. Operation of Horizontal Current Bipolar Transistors (HCBTs) at and beyond the limits of their linear operating area (LOA) and RF safe operating area (RF SOA) will be demonstrated, specifically in high-voltage (above breakdown), high-current and high RF power regimes, and related to their technology parameters. Low-temperature characterization of HCBT will assess the potential of low-cost, pure-Si, CMOS-compatible technology for cryogenic applications such as quantum computing, addressing all relevant physical effects.Novel structures of single-photon avalanche diodes (SPADs) will be designed in high-voltage CMOS technology with the aim to optimize their detection efficiency and noise performance. The measured characteristics of fabricated SPADs will be used to assess the impact of technology parameters on their electrical and optical performance. A 2D SPAD array together with the associated readout electronics will be designed and particularly optimized for timing performance and layout area suitable for harsh environments. The SPADs and arrays will also be fabricated in a down-scaled CMOS technology, which will provide a comprehensive technology comparison between the two nodes.Deep-level defects at all heterointerfaces in Pure(Ga)B diodes, which are critical for their electrical and optical performance, will be thoroughly characterized in steady-state, AC and transient domains from room to deep-cryogenic temperatures. Additionally, the temperature dependence of vertical and lateral conduction in PureB and PureGaB layers on various crystalline substrates (Si, SiGe, Ge) will be examined. A fully scalable 2D device model will be developed for a wide temperature range.]]></summary_en></project><project>
<id>18247</id><title_hr><![CDATA[Podacima pogonjena identifikacija i redukcija dimenzije dinamičkih sustava]]></title_hr><title_en><![CDATA[Data driven identification and dimension reduction of dynamical systems]]></title_en><user_id>2945</user_id><user_firstLast_name>Zlatko Drmač</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-3733</code><acronim><![CDATA[PPIRDS]]></acronim><duration>30.01.2026 - 29.01.2029</duration><status>U tijeku</status><financ_value>126.385,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>5056, 4757, 870122, 870118, </team_members_id><team_members_names><![CDATA[Zvonimir Bujanović, Nela Bosner, Ela Đimoti, Hrvoje Olić, ]]></team_members_names><keywords_hr><![CDATA[EDMD, Koopmanov operator, dinamički sistemi, podacima pogonjene primjene, randomizirani algoritmi, tenzorske dekompozicije]]></keywords_hr><keywords_en><![CDATA[EDMD, Koopman operator, dynamical systems, data driven applications, randomized algorithms, tensor decompositions]]></keywords_en><summary_hr><![CDATA[Ovaj projektni prijedlog ima tri komponente:(K1) Podacima pogonjena analiza nelinarnih dinamičkih sustava pomoću Koopmanovog operatora i numeričkih metoda Extended Dynamic Mode Decomposition (EDMD) i KSD (Koopman-Schur Decomposition). Tehnike bazirane na Koopanovom operatoru zadnjih godina postaju sve popularnije, zbog univerzalnosti primjene i dokazano dobrih rezultata. U kontekstu redukcije dimenzije, bit će proučavana i metoda diskretne empirijske interpolacije (DEIM), te mogućnosti njene primjene u kontekstu DMD/KSD.(K2) Randomizirani algoritmi. Trenutno su randomizirani algoritmi predmet intenzivnih istraživanja u svim područjima znanstvenog računanja. U kontekstu ovog projekta su nam zanimljivi prvenstveno zbog izvrsnih performansi u računanju aproksimacija malog ranga za matrice i tenzore, te mogućnosti primjene  u K1 i K3.(K3) Tenzorske dekompozicije s primjenama. Modeli visoke rezolucije koji vjerno opisuju procese i objekte realnog svijeta u procesu diskretizacije i numeričkih simulacija često generiraju podatke strukturirane u tenzore velikog  reda. S takvim količinama podataka i odgovarajućim numeričkim algoritmima je moguće raditi samo ako su tenzori komprimirani koristeći tenzorske dekompozicije. Planiramo razvoj novih algoritama za TT i TT-cross dekompozicije, koristeći i tehnike iz K2, te primjene u istraživanjima u K1.Istraživanja su planirana tako da svaka od tri komponente ima svoj vlastiti tok i svoje ciljeve, koji su koordinirani s druge dvije komponente s idejom da se stvori sinergijski učinak. Ciljevi istraživanja su podijeljeni u dvije kategorije: (i) teorijski rezultati,  konstrukcija i analiza novih numeričkih algoritama; (ii) razvoj matematičkog softwarea, tj. konkretnih alata za primjene u prirodnim znanostima i inženjerstvu.Posebna vrijednost projekta su planirane dvije doktorske radnje i to iz područja koja su aktualna i sve važnija u primijenjenoj matematici i znanstvenom računanju, a nisu dovoljno razvijena na MO PMF.]]></summary_hr><summary_en><![CDATA[This project proposal has three components:(K1) Data-driven analysis of nonlinear dynamic systems using the Koopman operator and numerical methods Extended Dynamic Mode Decomposition (EDMD) and KSD (Koopman-Schur Decomposition). Koopman operator-based techniques have become increasingly popular in recent years due to their universal applicability and proven strong results. In the context of dimension reduction, the DEIM method  will also be studied, along with the possibilities of its application in  DMD/KSD.(K2) Randomized algorithms. Currently, randomized algorithms are the subject of intense research in all areas of scientific computing. In this project, they are particularly interesting due to their excellent performance in computing low-rank approximations for matrices and tensors, and their potential application in K1, K3.(K3) Tensor decompositions with applications. High-resolution models that describe processes and objects in the real world, in the process of discretization and numerical simulations, often generate data structured in high-order tensors. With such large amounts of data, and the corresponding numerical algorithms, it is possible to work only if tensors are compressed using tensor decompositions. We plan to develop new algorithms for TT and TT-cross decompositions, using techniques from K2, as well as applications in K1.Each of the three components has its own flow and objectives, which are coordinated with the other two components with the idea of creating a synergistic effect.The goals are divided into two categories: (i) theoretical results, construction and analysis of new numerical algorithms; (ii) development of mathematical software, i.e., tools for applications in natural sciences and engineering.A special value of the project are the two doctoral theses in increasingly important areas in applied mathematics and scientific computing but have not been sufficiently developed at the Faculty of Science, University of Zagreb.]]></summary_en></project><project>
<id>18249</id><title_hr><![CDATA[Globalna i lokalna dinamika na plohama]]></title_hr><title_en><![CDATA[]]></title_en><user_id>2932</user_id><user_firstLast_name>Goran Radunović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-5033</code><acronim><![CDATA[GLODS]]></acronim><duration>15.12.2025 - 14.12.2031</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>872996</team_members_id><team_members_names><![CDATA[ Doktorand: Fran Mišković ]]></team_members_names><keywords_hr><![CDATA[Henonovo i Lozijevo preslikavanje, granični ciklus, bifurkacija, kompleksna dimenzija, stohastički fraktal, sporo-brzi sustav, singularna perturbacija]]></keywords_hr><keywords_en><![CDATA[Henon map, Lozi map, Dulac problem, limit cycle, bifurcation, complex dimension,  stochastic fractal,  slow-fast system, singular perturbation]]></keywords_en><summary_hr><![CDATA[Dinamički sustavi su zanimljivi  teorijskoj i primijenjenoj matematici. Matematičko modeliranje prirodnih i društvenih pojava te predviđanje njihovog ponašanja daje vrijedan doprinos matematici, znanosti i inženjerstvu. Naši istraživački ciljevi povezani su s poznatim otvorenim problemima u dinamici. (1) Dinamika Hénonovih  i Lozijevih  preslikavanja.  Neobični  atraktor dobro je poznata pojava u kaotičnoj dinamici. Činjenica da Hénonovi atraktori modeliraju ponašanje difeomorfizama s homokliničkim tangentama, čini ih univerzalnom strukturom za proučavanje kaosa. Analiziramo topološku strukturu, dinamička svojstva i homokliničke točke neobičnih atraktora  Hénonovskih i Lozijevskih preslikavanja. (2) Singulariteti vektorskih polja i difeomorfizama i njihove bifurkacije.Slavni Hilbertov 16. problem ili Dulacov problem postavlja pitanje gornje ograde  broja graničnih ciklusa ravninskih polinomijalnih sustava. Problem  se svodi na traženje broja lokalnih fiksnih točaka Poincaréovog   preslikavanja oko invarijantnih skupova. Analiziramo  rješenje Dulacovog problema za koje je nedavno primijećeno da ima pogrešku. Pristup uključuje analizu epsilon-okoline orbite, metodu koja  dolazi iz fraktalne geometrije. (3) Povezivanje kompleksnih dimenzija sa stohastičkim fraktalima i  mjerama zakrivljenosti.Kompleksna dimenzija skupa, definirana kao skup polova  Lapidusove  zeta funkcije te povezana s poznatom Riemannovom zeta funkcijom, bit će generalizirana za stohastičke fraktale i povezana s nedavno razvijenom teorijom mjere fraktalne zakrivljenosti. (4) Fraktalna analiza familije orbita u ravninskim sporo-brzim sustavima. Singularne perturbacije bit će razmatrane korištenjem fraktalne geometrije i standardnih metoda kao što su blow-up i spori integrali divergencije.  Dimenzija i sadržaj Minkowskog mogu se koristiti za proučavanje graničnih ciklusa i bifurkacija u blizini patkastih periodičnih graničnih skupova ili kontaktnih točaka u 2-dimenzionalnim sporo-brzim sustavima.]]></summary_hr><summary_en><![CDATA[Analysis of dynamical systems has been recognized as an interesting subject in mathematics pure and applied. Mathematical modeling of  real world systems  and prediction of their behavior gives a valuable contribution to mathematics, science and engineering. Our research goals are related to some well-known long-standing open problems  in dynamics. (1) Dynamics of the Hénon and Lozi maps. The strange attractor is a well-known phenomenon in chaotic dynamics. The fact that the Hénon-like attractors model the behavior of diffeomorphisms with homoclinic tangencies, makes them a universal structure in the onset of chaos. We study topological structure, dynamical properties and homoclinic points of the  Hénon-like and Lozi-like strange attractors. (2)  Singularities of vector fields and diffeomorphisms and their bifurcations.The famous Hilbert 16th problem or the Dulac problem, which ask for an upper bound on the number of limit cycles in planar polynomial systems, are reduced to counting local fixed points of the first return maps around invariant sets. Here, the mistaken solution of the Dulac  problem will also be studied. New approach includes analysis of epsilon-neigborhood of an orbit using the idea  from fractal geometry.(3)  Relating complex dimensions to stochastic fractals and their curvature measures. The complex dimension of a set,  defined as the poles of the Lapidus (fractal) zeta function and related to the famous Riemann zeta function,  will be generalized to the stochastic setting and connected  to the theory of fractal curvature measures recently developed.(4) Fractal analysis of families of orbits in planar slow-fast systems.Singular perturbations  will be considered using standard methods such as blowing-ups, slow divergence integrals, and also  fractal geometry.  Minkowski dimension and content, fractal strings, etc. can be used to study limit cycles and bifurcations near canard limit periodic sets or contact points in 2-dimensional slow-fast systems.]]></summary_en></project><project>
<id>18250</id><title_hr><![CDATA[Diracovi operatori, Cliffordove algebre i njihovi kvantni analogoni]]></title_hr><title_en><![CDATA[Dirac operators, Clifford algebras and their quantum analogues]]></title_en><user_id>5573</user_id><user_firstLast_name>Pavle Pandzic</user_firstLast_name><svouser_id>870807</svouser_id><svouser_firstLast_name>Andrey Krutov</svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-6514</code><acronim><![CDATA[DOCAQA]]></acronim><duration>05.12.2025 - 04.12.2028</duration><status>U tijeku</status><financ_value>191.696,10 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>5954, </team_members_id><team_members_names><![CDATA[Ana Prlić, ]]></team_members_names><keywords_hr><![CDATA[Diracov operator, Cliffordova algebra, Liejeva algebra, kvantna grupa, Cliffordova analiza, teorija reprezentacija]]></keywords_hr><keywords_en><![CDATA[Dirac operator, Clifford algebra, Lie algebra, quantum group, Clifford analysis, representation theory]]></keywords_en><summary_hr><![CDATA[Ovaj ambiciozni projekt usmjeren je na proširenje interakcije između teorije reprezentacija, geometrije i analize. Projekt je podijeljen u dva glavna dijela: (i) Cliffordove algebre; (ii) Diracovi operatori. U prvom dijelu projekta istražujemo strukturuCliffordovih algebri povezanih sa simetričnim parovima s ciljem generalizacije klasične konstrukcije na kvantnu razinu. Naša motivacija dolazi iz izuzetno uspješnih primjena Cliffordovih algebri u analizi, geometriji i teoriji reprezentacija. Udrugom dijelu, istražujemo upotrebu algebarskih Diracovih operatora u proučavanju unitarnih modula. Konačno, cilj nam je generalizirati konstrukcije Diracovih operatora na slučaj kvantnih grupa, kvantnih simetričnih parova i kvantne Cliffordoveanalize. Daljnji srodni istraživački zadaci spajaju teoriju reprezentacija Liejevih grupa, klasičnu i nekomutativnu geometriju. Projektni podtimovi osiguravaju jedinstveno komplementarno vrhunsko iskustvo u dotaknutim vrućim međunarodnim temama, uključujući njihovu široku međunarodnu mrežu suradnje.]]></summary_hr><summary_en><![CDATA[This ambitious project focuses on extension of interaction between representation theory, geometry, and analysis. The project is divided into two main parts: (i) Clifford algebras; (ii) Dirac operators. In the first part of the project, we investigate the structureof Clifford algebras associated to symmetric pairs aiming to generalize classical constructions on a quantum level. Our motivation comes from extremely successful applications of Clifford algebras in analysis, geometry, and representation theory. In the second part, we explore the use of algebraic Dirac operators in the study of unitary modules. Finally, we aim to generalize constructions of Dirac operators to the case of quantum groups, quantum symmetric pairs, and the framework of quantum Clifford analysis. Further related research tasks bring together the representation theory of Lie groups, and classical and noncommutative geometries. The project subteams provide unique complementary top experience in the touched hot international topics, including their wide cooperating international network.]]></summary_en></project><project>
<id>18253</id><title_hr><![CDATA[Materijali za primjene namijenjene fuziji]]></title_hr><title_en><![CDATA[Materials For Fusion Intended Applications]]></title_en><user_id>3922</user_id><user_firstLast_name>Andreja Gajović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-7971</code><acronim><![CDATA[MaFFIA]]></acronim><duration>22.12.2025 - 21.12.2028</duration><status>U tijeku</status><financ_value>197.697,65 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, Kemija, </scie_field_hr><scie_field_en>Physics, Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>1362, 3012, 21267, 4893, 4589, 868001, 855354, 855358, 12832, 4702, 13242, 26046, 870681, 866045, 870776, </team_members_id><team_members_names><![CDATA[Maja Mičetić, Davor Gracin, Kristina Tomić Luketić, Tonči Tadić, Stjepko Fazinić, Mario Matić, Toni Dunatov, Juraj Ovčar, Jelena Macan, Tamara Aleksandrov Fabijanić, Zdenka Zovko Brodarac, Franjo Kozina, Luka Mesek, Miran Čeh, Sandra Drev, ]]></team_members_names><keywords_hr><![CDATA[Postrojenje za ionsko ozračavanje s dvostrukim snopom, fuzijski materijali, višekompon legure na bazi W, dielektr. keramika na bazi spinela, Eurofer]]></keywords_hr><keywords_en><![CDATA[Dual Beam Ion Irradiation Facility, Fusion Materials, W-based multicomponent alloys, spinel-based dielectric ceramic, Eurofer]]></keywords_en><summary_hr><![CDATA[Glavni cilj ovog projekta je poticanje razvoja novih fuzijskih materijala u Hrvatskoj; počevši od njihove sinteze i strukturne karakteriz. do mjerenja mehaničkih i električnih svojstava. Odabrani materijali će se istražiti za fuzijsku primjenu istodobnim bombardiranjem teškim ionima i He ionima u naprednom postrojenju za ionsko ozračavanje dvostrukim snopom za fuzijske materijale (DiFU), izgrađenom u našem Institutu posebno za proučavanje fuzijskog materijala kao jednom od samo desetak u svijetu.Usredotočit ćemo se na sintezu materijala i proučavanje učinaka zračenja dvostrukim ionskim snopom na: (1) višekomponentne legure na bazi W (3-6 komp.), pripremljene više-metnim magnetronskim rasprašenjem (MTMS) kao materijal za visoki tok u fuzijskim reaktorima; (2) dielektrična keramika na bazi spinela, pripremljena kem. sintezom kao funkcionalni materijal i (3) Eurofer čelik, koji će se kupiti za proučavanje u DiFU kao konstrukcijski materijal. Metode strojnog učenja, temeljene na našim eksperimentalnim rezultatima, primjenjivat će se za optimizaciju postupaka sinteze kako bi se dobili najbolji kandidati za primjenu u fuziji. Primjenjivat će se napredne tehnike za karakterizaciju materijala, uključujući (S)TEM atomske rezolucije.Depozicija MTMS-om, kao visokoučinkovita metoda, dat će nam više slobode u izboru sastava i omjera elemenata u višekomponentnim legurama na bazi W. Odabir elemenata za dobivanje najboljih svojstava za primjenu u fuziji, napravit će se na temelju računalne pretrage vođene podacima. Sličan pristup će se koristiti za odabir kationa koji će se ugraditi u kristalnu strukturu spinela. Štoviše, kao metodu izbora za strukturno proučavanje keramike, instalirat ćemo sondu za Ramanovu spektroskop. u DiFU komoru za ozračivanje i potvrditi njezinu funkcionalnost za izvođenje in-situ Ramanove studije keramike pod dvostrukim ionskim snopom. Ako instalacija i mjerenja budu uspješni, to će biti prvo postrojenje za ozračivanje dvostrukim snopom s in-situ Ramanom.]]></summary_hr><summary_en><![CDATA[The main goal of this project is to stimulate the development of novel fusion materials in Croatia; starting with their syntheses and structural characterization to the measurement of mechanical and electrical properties. Selected materials will be evaluated for fusion application by simultaneous bombardment by heavy ions and He ions in advanced Dual-Beam Ion Irradiation Facility for Fusion Materials (DiFU), constructed at our Institute specifically for the study of fusion materials as one of only a dozen worldwide. We will concentrate on the synthesis of materials and study of dual ion beam irradiation effects on: (1) W-based multicomponent alloys (3-6 components), prepared by multi-target magnetron sputtering (MTMS) as high flux materials in fusion reactors; (2) spinel-based dielectric ceramics, prepared by chemical syntheses as functional material and (3) Eurofer steel, which will be purchased as structural material for study in DiFU. Machine learning methods, based on our experimental results, will be applied to optimize the syntheses procedures to obtain the best candidates for fusion application. Advanced techniques will be applied for material characterization, including atomic resolution (S)TEM.Deposition by MTMS, as a high-throughput method, will give us more freedom in choice of the elemental composition and element ratios in multicomponent W-based alloys. Choices of elements to obtain the best properties for fusion application will be made on the basis of a data-driven computational search. A similar approach will be used to select cations to be introduced in the crystalline structure of spinel. Moreover, as a method of choice for the structural study of ceramics, we will install a Raman spectroscopy probe in the DiFU irradiation chamber and validate its functionality to perform in-situ Raman study of ceramics under dual ion beam. If the installation and measurements are successful, it will be the first dual beam irradiation facility with in-situ Raman.]]></summary_en></project><project>
<id>18261</id><title_hr><![CDATA[Procjena važnosti i geneze čestica koje sadrže renij u morskom okolišu]]></title_hr><title_en><![CDATA[Evaluation of the importance and formation of rhenium-containing particles in the marine environment]]></title_en><user_id>561</user_id><user_firstLast_name>Elvira Bura-Nakić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-5211</code><acronim><![CDATA[RHEMAR]]></acronim><duration>10.12.2025 - 09.12.2028</duration><status>U tijeku</status><financ_value>194.920,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Interdisciplinarne prirodne znanosti, </scie_field_hr><scie_field_en>Interdisciplinary natural sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>290, 12837, 101, 870184, 870378, 870131, 869793, </team_members_id><team_members_names><![CDATA[Marija Marguš, Ana-Marija Cindrić, Marina  Mlakar, Tais W. Dahl, Arne Bratkič, Timotej Turk Dermastia, Narda Stipanović, ]]></team_members_names><keywords_hr><![CDATA[renij, čestice, jod, dušik, sediment, smeđe alge]]></keywords_hr><keywords_en><![CDATA[rhenium, particles, iodine, nitrogen, sediment, brown algae]]></keywords_en><summary_hr><![CDATA[Iako je akumulacija Re u anoksičnim sedimentima poznata desetljećima te se Re koristi za rekonstrukciju redoks uvjeta Zemljine atmosfere i oceana u prošlosti, iznenađujuće je da je malo ili gotovo nimalo pozornosti posvećeno razumijevanju biogeokemije Re u oksičnim uvjetima (s obzirom na vodeni stupac). Sedimentni zapisi pružaju nam dokaz o efemernim česticama Re koje se stvaraju u stupcu oksične vode, ali čije je podrijetlo nepoznato, iako postoje indikacije da nastaju biološkom aktivnošću morskih organizama. Razumijevanje mehanizma njihovog formiranja i očuvanja u sedimentu imalo bi značajne implikacije za naše razumijevanje principa rada Re paleoredoks indikatora, gdje se sedimentni Re zapis može koristiti ne samo kao paleoredoks već i kao indikator paleoproduktivnosti. Jedna od premisa projekta je pretpostavka važne uloge smeđih algi u biogkemijskom ciklusu Re. U okviru projekta istraživati će se bioakumulacija Re u smeđim algama s naglaskom na istraživanje sličnosti/razlika između ciklusa Re, joda i dušika budući da biološka uloga Re (ako postoji) još nije poznata. Također će se istražiti potencijalna uloga fitoplanktona (dijatomeja zbog njihove poznate filogenetske veze sa smeđim algama) s obzirom na bilancu mase Re u moru. Rad na razumijevanju mehanizma akumulacije/unosa Re od strane morskih fotosintetskih organizama važan je dio projekta, gdje će se koristiti različiti analitički pristupi (spektrometrija masa, kromatografija u stupcu, elektrokemija, fina struktura redgenske apsorpcije blizu ruba) za razjašnjavanje interakcija Re s izvan- ili eventualno unutarstaničnim matriksom. Adsorpcijska svojstva minerala gline s obzirom na Re također su zanemarena, no projekt će preispitati ulogu glinenih minerala u odnosu na distribuciju Re u morskim sedimentima. ]]></summary_hr><summary_en><![CDATA[Although Re accumulation in anoxic environments has been known for decades and Re is used to reconstruct redox conditions in the Earth&#39;s atmosphere and oceans in the past, it is surprising that little or almost no work has been devoted to understanding Re biogeochemistry in oxic environments (with respect to the water column). The sediment signatures provide us with evidence of evanescent Re particles that form in the oxic water column but whose origin is unknown, although there is indication that they are formed by biological activity. Understanding the mechanism of their formation and preservation in the sediment would have significant implications for our understanding of the operating principle of the Re paleoredox proxy, where sedimentary Re signatures could be used not only as a paleoredox but also as a paleoproductivity indicator. We hypothesize that algae play an important role in the biogeochemical cycle of Re. The project will address the bioaccumulation potential of brown algae on the eastern Adriatic coast, focusing on investigating the similarities/differences between Re, iodine and the nitrogen cycle, as the biological role of Re (if any) is not yet known. The potential role of phytoplankton (diatoms due to their known phylogenetic link to brown algae) in the marine Re budget will also be investigated. Determining the mechanism of Re accumulation/uptake by marine macrophytes and phytoplankton is an important part of the project, where different analytical approaches (mass spectrometry, column chromatography, electrochemistry,  X-ray absorption fine structure) will be used to elucidate the interactions of Re with the extra- or possibly intracellular matrix. The adsorption properties of clay minerals in relation to Re are also neglected, but the project will re-examine the role of clay minerals in relation to Re in marine sediments inventory. ]]></summary_en></project><project>
<id>18263</id><title_hr><![CDATA[Astronomija gama-zraka visokih energija u doba višečestičnih opažanja]]></title_hr><title_en><![CDATA[]]></title_en><user_id>25065</user_id><user_firstLast_name>Marina Manganaro</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-6845</code><acronim><![CDATA[ASTRO-GAMMA]]></acronim><duration>19.01.2026 - 18.01.2032</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci]]></institution_hr><institution_en><![CDATA[University of Rijeka]]></institution_en><team_members_id>873072</team_members_id><team_members_names><![CDATA[ Doktorand: Josiah Olumuyiwa FANIYI ]]></team_members_names><keywords_hr><![CDATA[Astronomija, Astrofizika, Visoka energija, Gama-zrake, Astronomija ija s više valnih duljina, Čerenkovljevi teleskopi, Astrofizika čestica, Kvantna gr]]></keywords_hr><keywords_en><![CDATA[Astronomy, Astrophysics, High Energy, Gamma-rays, Multi-messenger astronomy, Multi-wavelength astronomy, Cherenkov telescopes, Astroparticle physics, ]]></keywords_en><summary_hr><![CDATA[Nedavno otkriće neutrina emitiranih iz blazara, aktivne galaktičke jezgre za koju znamo da emitira fotone u cijelom elektromagnetskom spektru do najviših energija, jedan je od ključnih događaja koji potvrđuje početak višeglasničke ere u astrofizici. Važan dio te slike je gama-astronomija, područje koja istražuje fotone na najvišim energijama, proizvedene u najnasilnijim procesima u svemiru. S našim prijedlogom želimo ne samo konsolidirati istraživanja gama-astronomije koja se provode u međunarodnoj suradnji kao što su MAGIC (Major Atmospheric Gamma-ray Cherenkov telescopes) i CTA (Cherenkov Telescope Array), već i proširiti hrvatski doprinos ovom području prema teorijskoj interpretaciji rezultata u kontekstu višeglasničke astronomije. To znači da će, uz potvrđeno iskustvo koje proizlazi iz dugogodišnjih znanstvenih rezultata u grani gama-astronomije, naša grupa također raditi na teorijskoj interpretaciji i modeliranju rezultata u širokopojasnom prikazu te na istraživanju učinaka kvantne gravitacije, kao što je narušenje Lorentzove invarijantnosti (LIV). Ovo širenje vidika je pravodobno jer je razumijevanje teorijskih modela ključ za otkrivanje procesa emisije različitih izvangalaktičkih i galaktičkih izvora, uključujući i one najnovije otkrivene na najvišim energijama, nazvane PeVatroni. Kako bismo istražili ta nova energijska područja, radit ćemo na razvoju novog Čerenkovljevog detektora za novu stratešku suradnju sa SWGO (Southern Wide-field Gamma-Ray Observatory).]]></summary_hr><summary_en><![CDATA[The recent discovery of a neutrino emitted by a blazar, an active galactic nucleus known to emit photons across the entire electromagnetic spectrum up to the highest energies, has been one of the key events confirming that we are witnessing a multi-messenger era in astrophysics. Gamma-ray astronomy is an important part of this picture, being the discipline that studies photons at the highest energies, produced in the most violent processes in the Universe. With our proposal we aim to consolidate the gamma-ray astronomy research conducted in international collaborations as MAGIC (Major Atmospheric Gamma-ray Cherenkov telescopes) and CTA (Cherenkov Telescope Array), and moreover to widen the Croatian-based contribution to this field moving towards the theoretical interpretation of the results in a multi-messenger context. This means that, on top of  the proven experience coming from years of scientific results in the field of gamma-ray astronomy, the team will also work on the theoretical interpretation and modelling of the results in a broadband view and on the investigation of quantum gravity effects such as Lorentz Invariance Violation. This expansion of horizons is timely since the understanding of the theoretical models is the key to unveil  the emission process of different extragalactic and galactic sources, including the newest ones discovered at the highest energies, the so-called PeVatron sources. To explore such new energy frontiers we will also work in the development of a novel Cherenkov detector for the new strategic collaboration with the SWGO (Southern Wide-field Gamma-Ray Observatory).]]></summary_en></project><project>
<id>18270</id><title_hr><![CDATA[Nova primjena biopolimera biljnog podrijetla u svrhu poboljšanja stabilnosti i biološke aktivnosti bioaktivnih komponenata]]></title_hr><title_en><![CDATA[Novel applications of plant-based biopolymers for maximizing stability and health-promoting functionality of bioactive compounds]]></title_en><user_id>7246</user_id><user_firstLast_name>Mirela Kopjar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-3588</code><acronim><![CDATA[NovelAppForBioFun]]></acronim><duration>05.12.2025 - 04.12.2028</duration><status>U tijeku</status><financ_value>199.996,50 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Prehrambena tehnologija, </scie_field_hr><scie_field_en>Food technology, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Prehrambeno-tehnološki fakultet]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Food Technology]]></institution_en><team_members_id>7296, 26271, 25662, 7330, 868170, 27076, 870642, 25600, </team_members_id><team_members_names><![CDATA[Anita Pichler, Ivana Ivić, Josipa Krezić, Josip Simunovic, Drazen Raucher, Mary Ann Lila, Dubravko Pichler, Vanja Kelemen, ]]></team_members_names><keywords_hr><![CDATA[bioaktivne komponente, biopolimeri, aerogelovi, hidrogelovi, liofilizirani prahovi]]></keywords_hr><keywords_en><![CDATA[bioactive compounds, biopolymers, aerogels, hydrogels, freeze-dried powders]]></keywords_en><summary_hr><![CDATA[Polifenoli su jedni od biljnih sekundarnih metabolita koji su poznati po pozitivnom utjecaju na zdravlje (regulacije hiperglikemije, zaštite od kardiovaskularnih poremećaja, antikancerogenog, protuupalnog i antioksidativnog potencijala), ali također osiguravaju boju, aromu i oksidativnu stabilnost biljaka. Tijekom godina sve veća svijest potrošača o povezanosti prehrane i zdravlja te općeprihvaćena činjenica da voće ima dodanu vrijednost u promicanju ljudskog zdravlja, potaknuli su brojna istraživanja o voću bogatom bioaktivnim komponentama. U ovom projektu, aronija, višnja, nar i drijenak odabrani kao izvor bioaktivnih komponenata obzirom da su bogati izvori polifenola (proantocijanidini, fenolne kiseline, flavonoidi) i karakterističnog su aromatskog profila. Međutim, ovi spojevi (osobito antocijani) vrlo su nestabilni tijekom procesiranja i skladištenja. Za zaštitu bioaktivnih i aromatskih komponenata, primijeniti će se dva pristupa, inkapsulacija i kopigmentacija. Inkapsulacija će se primijeniti za kreiranje učinkovitih tzv „delivery systems“ oba tipa ciljanih komponenata, tako da će se formulirati aerogeli, hidrogelovi i liofilizirani prahovi. Dodatno, za postizanje stabilnosti antocijanina koristit će se kopigmentacija. Biopolimeri biljnog podrijetla, poput dijetalnih vlakana i proteina, primijenit će se kao nositelji aktivnih komponenti. Oba tipa biopolimera se preporučuju u ljudskoj prehrani, ali također osiguravaju tehnološka svojstva hrani. Dobiveni „delivery systems“ mogu se koristiti kao funkcionalni dodatci hrani kako bi se proizvodi kojima bi se dodavali obogatili bioaktivnim spojevima, vlaknima ili proteinima te kako bi se poboljšala njihova biološka aktivnost. Ovi „delivery systems“ mogu se koristiti kao pojačivači boje i okusa, te za produljenje roka trajanja proizvoda. Također, rezultati ovog projekta mogu doprinijeti kreiranju „delivery systems“ koji imaju potencijal inhibicije stanica tumora, sami ili u kombinaciji sa standardnim kemoterapeutikom.]]></summary_hr><summary_en><![CDATA[Polyphenols are one of plant secondary metabolites that possess health-promoting potential (regulation of hyperglycemia, protection from cardiovascular disorders, anticancer, anti-inflammation and antioxidant potentials) but also provide color, flavor, and oxidative stability to plants. Over the years, the increased consumer awareness of the relation between diet and health, and broadly accepted fact that fruits have an added value in promoting health, has motivated numerous studies on investigating fruits rich in bioactive compounds. Chokeberry, tart cherry, pomegranate and cornelian cherry selected as sources of bioactive compounds in this project are rich sources of polyphenols (proanthocyanidins, phenolic acids, flavonoids) and are characterized by specific flavor profile. However, these compounds (especially anthocyanins) are highly unstable under processing and storage conditions. Two approaches will be taken for protection of bioactive and flavor compounds, encapsulation and copigmentation. Encapsulation will be applied to design efficient delivery systems of both targeted compounds, thus aerogels, hydrogels and freeze-dried powders will be formulated. Additionally to achieve stability of anthocyanins copigmentation will be employed. Plant-based biopolymers, such as dietary fibers and proteins, will be applied as carriers of active components. Both are highly recommended in human diet but also provide technological properties to foods. Obtained delivery systems can be used as functional food additives in order to fortify products to which they would be added with bioactive compounds, fibers or proteins, and to achieve higher health-promoting functionally. These delivery systems can be used as colour and flavour enhancers, to prolong the shelf life of products since they can prevent oxidative degradation. Also, these results can facilitate the creation of delivery systems which target cancer cells, alone or in combination with the standard chemotherapeutic.]]></summary_en></project><project>
<id>18271</id><title_hr><![CDATA[Derivati cijaninskih boja – nove probe za nukleinske kiseline i bioprobe sa antitumorskim i antibakterijskim djelovanjem]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1214</user_id><user_firstLast_name>Marijana Radić Stojković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-1031</code><acronim><![CDATA[CyaBioProbe]]></acronim><duration>16.01.2026 - 15.01.2031</duration><status>U tijeku</status><financ_value>60,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>873011</team_members_id><team_members_names><![CDATA[ Doktorand: Nina Vukadinović ]]></team_members_names><keywords_hr><![CDATA[organska sinteza, cijaninske probe, DNA i RNA prepoznavanje, primjena hidrogelova, teranostički učinak, istraživanja in vitro i in vivo]]></keywords_hr><keywords_en><![CDATA[organic synthesis, cyanine probes, DNA and RNA recognition, application of hydrogels, theranostic effect, in vitro and in vivo research ]]></keywords_en><summary_hr><![CDATA[Primjena molekularnih proba za vizualizaciju biomolekula i bioloških uzoraka dobiva na važnosti u biokemijskim i biomedicinskim istraživanjima. Osim detekcije biološke mete, neke probe pokazuju antitumorske i antibakterijske učinke. Ovo svojstvo je osobito značajno s obzirom na porast otpornosti na antibiotike i sve veću učestalost raznih vrsta raka.Među brojnim nekovalentnim probama malih molekula, cijaninske boje poznate su kao izvrsne probe za nukleinske kiseline i sredstva i za in vitro i in vivo vizualizaciju i terapijsku upotrebu. Monometinske i polimetinske cijaninske boje su odlične molekularne probe zbog svojih značajki, kao što su visoki ekstinkcijski koeficijenti, dublje prodiranje u tkivo, smanjena pozadinska autofluorescencija i osjetljivost na njihovu molekularnu okolinu.Očekuje se da će projekt rezultirati novim bioprobama s monometinskim i polimetinskim (tri-, penta- i uglavnom heptametinskim) cijaninskim strukturama s mogućnošću prepoznavanja meta, njihove vizualizacije i/ili biološkog učinka. To će se postići ispunjavanjem sljedećih ciljeva: sinteza novih spojeva, istraživanje njihovih interakcija s biomakromolekulama te proučavanje biološkog učinka in vitro i in vivo. Također će se istraživati nano-hidrogelovi kao sustavi isporuke za terapeutsku primjenu.Projekt će pridonijeti obogaćivanju u području istraživanja i sintetske knjižnice našeg laboratorija novom generacijom proba na bazi cijanina s potencijalom vizualizacije i selektivnog prepoznavanja bioloških meta i terapeutika. Omogućit će objavljivanje rezultata istraživanja u kvalitetnim časopisima, te ojačati međuinstitucijsku suradnju. Novi derivati cijanina mogu se primijeniti u molekularnoj medicini za detekciju specifičnih molekula/biomolekula, istraživanje i razvoj lijekova te praćenje bakterija otpornih na antibiotike u uzorcima iz okoliša, prehrambenim proizvodima i stočnoj hrani.]]></summary_hr><summary_en><![CDATA[The application of molecular probes for visualizing biomolecules and biological samples is gaining importance in biochemical and biomedical research. Besides biological target detection, some probes display antitumor and antibacterial effects. This feature is particularly significant given the rise of antibiotic resistance and the escalating incidence of various cancer types.Among numerous non-covalent small molecule probes, cyanine dyes are known as excellent nucleic acid probes and agents for in vitro and in vivo visualization and therapeutic use. Monomethine and polymethine cyanine dyes make excellent molecular probes due to their distinctive features, such as high extinction coefficients, deeper tissue penetration, reduced background autofluorescence and sensitivity to their molecular environment.The project is expected to result in new bioprobes with monomethine and polymethine (tri-, penta-, and mainly heptamethine) cyanine structures with the possibility of target recognition, their visualization, and/or biological effect. This will be achieved by fulfilling the following goals: synthesis of new compounds, investigating their interactions with biomacromolecules, and studying the biological effect in vitro and in vivo. Nanosized hydrogels as delivery systems for therapeutic applications will also be explored.The project will contribute to the enrichment of field research and the synthetic library of our laboratory with a new generation of cyanine-based probes with the potential for visualization and selective recognition of biological targets and therapeutics. It will enable the publication of research results in quality journals, and strengthen inter-institutional collaboration. New cyanine derivatives can be applied in molecular medicine for the detection of specific molecules/biomolecules, drug research and development and the monitoring of antibiotic-resistant bacteria in environmental samples, food products and animal feed.]]></summary_en></project><project>
<id>18272</id><title_hr><![CDATA[Omika pristup u otkrivanju novih biomarkera izvanstaničnih vezikula u bolestima srca pasa]]></title_hr><title_en><![CDATA[Multi-omics approach in discovering novel biomarkers of extracellular vesicles in cardiac disease of dogs]]></title_en><user_id>801</user_id><user_firstLast_name>Vladimir Mrljak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-7131</code><acronim><![CDATA[ExtraDog]]></acronim><duration>15.12.2025 - 14.12.2028</duration><status>U tijeku</status><financ_value>199.973,00 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Veterinarska medicina, Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Veterinary medicine, Clinical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Veterinarski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Veterinary Medicine]]></institution_en><team_members_id>6734, 6678, 868324, 2720, 4115, 6965, 11273, 868492, 6338, 868435, 868536, 19799, 870127, </team_members_id><team_members_names><![CDATA[Josipa Kuleš, Martina Crnogaj, Elizabeta Pongrac, Blanka Beer Ljubić, Marin Torti, Renata Barić Rafaj, Damjan Gračner, Alberto Munoz Prieto, Jose Ceron, Ines Jović, Iva Šmit, Dina Rešetar Maslov, Dominik Prišćan, ]]></team_members_names><keywords_hr><![CDATA[Proteomika, metabolomika, bolesti srca, izvanstanične vezikule, pas]]></keywords_hr><keywords_en><![CDATA[Proteomics, metabolomics, diseases of the heart, extracellular vesicles, dog]]></keywords_en><summary_hr><![CDATA[Miksomatozna degeneracija mitralne valvule (MMVD) je najčešća stečena bolest srca i jedan od najvažnijih uzroka lijevostranog zatajivanja srca u pasa. Dijagnoza MMVD primarno se temelji na kliničkim znakovima i slikovnoj dijagnostici. Bez kliničkih znakova ili slikovne dijagnostike teško je prepoznati razvoj bolesti, što je osobito važno u asimptomatskoj fazi. Važnost definiranja ranih dijagnostičkih biomarkera MDMV kod pasa je od iznimnog značaja. Nedavni razvoj molekularne kardiologije pokazao je da izvanstanične vezikule (EVs) mogu poslužiti kao potencijalni biomarkeri kardiovaskularnih bolesti. Cirkulirajuće EVs imaju ključnu ulogu u međustaničnoj komunikaciji i obećavajuću primjenu u dijagnostici i praćenju bolesti. Razvoj  tehnika koje se temelje na spektrometriji mase, u proteomici i metabolomici, omogućuje ,,-omica&#39;&#39; pristup u otkrivanju novih biomarkera EVs u srčanim bolestima pasa. Naš projekt koristi ,,-omica&#39;&#39; pristup u istraživanju biomarkera cirkulirajućih EVs izoliranih iz seruma pasa s različitim stadijima razvoja MMVD. Pretpostavljamo da EVs iz seruma odražavaju fiziološke i patofiziološke procese, što dovodi do razlika u molekularnom teretu (proteom i metabolom) između EVs pasa dijagnosticiranih s MMVD i  zdravih pasa. Naši ciljevi uključuju izolaciju i karakterizaciju EVs iz seruma pasa s različitim stadijima MMVD i zdravih pasa, karakterizaciju molekularnog tereta EVs primjenom proteomike i metabolomike, usporedbu EV proteoma i metaboloma pasa s različitim stadijima MMVD međusobno i zdravih pasa, otkrivanje ranih, dijagnostičkih i razlikovnih biomarkera EVs kod pasa s MMVD-om integriranim ,,-omica&#39;&#39; pristupom, identifikaciju promijenjenih molekularnih signalnih putova u svrhu pojašnjenja patofizioloških procesa razvoja bolesti i istraživanje interakcije između proteina i metabolita te poboljšanje dijagnostike MMVD što će rezultirati dužim preživljavanjem pacijenata. ]]></summary_hr><summary_en><![CDATA[Myxomatous mitral valve disease (MMVD) is the most prevalent acquired heart disease and one of the most important causes of left-sided heart morbidity in dogs. Currently, diagnosis of MMVD is primarily based on clinical signs and imaging. Without clinical signs or imaging, it is hard to recognize the development of the disease, which is especially important in asymptomatic phase. The importance of defining early diagnostic biomarkers of MMVD in dogs is of utmost significance. Recent developments in molecular cardiology have shown that extracellular vesicles (EVs) can serve as potential biomarkers in cardiovascular diseases. Circulating EVs have a key role as bioactive mediators of intercellular communications and promising applications in diagnosis and disease monitoring. The development of mass spectrometry-based techniques, like in proteomics and metabolomics, allows a multi-omics approach to discovering novel biomarkers of EVs in the cardiac disease of dogs. Our project employs a multi-omics approach to investigate biomarkers of circulating EVs isolated from dogs with different stages of MMVD development. We hypothesize that EVs from serum reflect physiological and pathophysiological processes, leading to distinct molecular cargo (proteome and metabolome) differences between EVs of dogs diagnosed with MMVD and healthy dogs. Our goals include the isolation and characterization EVs from serum of dogs with different stages of MMVD and healthy dogs, characterization of EV using proteomics and metabolomics, comparing EV proteomes and metabolomes of dogs with different stages of MMVD versus healthy dogs’ EVs, discovering early-stage diagnostic EV biomarkers in dogs with MMVD by integrated multi-omics approach, identifying involved molecular signaling pathways, in order to clarify the pathophysiological processes of disease development and investigation of interactions between proteins and metabolites, improving the diagnostics of MMVD and longer patient survival.]]></summary_en></project><project>
<id>18274</id><title_hr><![CDATA[Razvoj zelenih analitičkih metoda za otkrivanje čimbenika interindividualne farmakokinetičke varijabilnosti ciljanih antitumorskih lijekova]]></title_hr><title_en><![CDATA[Development of green analytical methods for identifying factors of interindividual pharmacokinetic variability of targeted anticancer drugs]]></title_en><user_id>13100</user_id><user_firstLast_name>Miranda Sertić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-1882</code><acronim><![CDATA[GreenOncoPK]]></acronim><duration>05.12.2025 - 04.12.2028</duration><status>U tijeku</status><financ_value>197.400,00 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Farmacija, Javno zdravstvo i zdravstvena zaštita, </scie_field_hr><scie_field_en>Pharmaceutical sciences, Public health and health services, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Farmaceutsko-biokemijski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Pharmacy and Biochemistry]]></institution_en><team_members_id>13122, 865246, 869877, 855971, 26562, 870140, 870724, 865653, 26603, 26811, 865567, 4758, 865564, 4721, 4391, </team_members_id><team_members_names><![CDATA[Biljana Nigović, Zvonimir Mlinarić, Kristian Morić-Španić, Lu Turković , Tajana Silovski, Iztok Grabnar, Oscar Ekpenyong, Martin Kondža, Slaven Crnkovic, Natalija Dedić Plavetić, Maja Ortner Hadžiabdić, Hrvoje Rimac, Matea Baković, Mila Lovrić, Dragana Mutavdžić Pavlović, ]]></team_members_names><keywords_hr><![CDATA[zelene analitičke metode, inovativna priprema biološkog uzorka, terapijsko praćenje lijekova, ciljani oralni antitumorski lijekovi, farmakokinetika]]></keywords_hr><keywords_en><![CDATA[green analytical methods, inovative sample preparation methods, therapeutic drug monitoring, targeted oral antitumor drugs, pharmacokinetics]]></keywords_en><summary_hr><![CDATA[Rak je jedan od najvećih globalnih zdravstvenih izazova. U suvremenoj onkologiji pristupi liječenju usmjereni su na specifične molekularne ciljeve. Ciljani oralni antitumorski lijekovi, posebice inhibitori kinaza i PARP inhibitori, revolucionarno su unaprijedili učinkovitost i podnošljivost liječenja u odnosu na tradicionalnu citotoksičnu terapiju. No, veliki nedostatak ovih lijekova je interindividualna farmakokinetička (PK) varijabilnost koja može dovesti do razlika u učinkovitosti i toksičnosti iste doze kod različitih bolesnika. Potencijalno rješenje ovog problema je individualizacija doziranja na temelju koncentracije lijeka u organizmu i specifičnih karakteristika poput dobi, tjelesne mase, funkcije jetre i bubrega. Cilj ovog istraživanja je razviti inovativne, zelene, automatizirane i minijaturizirane predanalitičke postupke obrade biološkog uzorka te pouzdane, osjetljive i napredne analitičke metode za određivanje izloženosti ciljanim oralnim antitumorskim lijekovima kod bolesnika. Osim uzorka plazme kao zlatnog standarda, bit će ispitan potencijal uzorkovanja suhe kapi krvi i sline kao manje invazivnih postupaka prilagođenih bolesniku. Za procjenu varijabilnosti koristit će se inovativni pristup primjenom populacijskih PK modela, koji olakšava kliničku interpretaciju analitičkih rezultata u kontekstu cjelokupnog zdravstvenog stanja bolesnika. Procijenit će se značaj varijabilnosti s obzirom na njenu učestalost i utjecaj na terapijsku učinkovitost i toksičnost. Posebna pozornost pridat će se utjecaju metaboličkih interakcija s drugim lijekovima te neadherencije na PK varijabilnost u realnoj kliničkoj praksi. Predloženo istraživanje ima ključni značaj u razumijevanju kliničkih implikacija varijabilnosti skupih, ciljanih antitumorskih lijekova. Omogućit će razvoj sigurnijih protokola njihove primjene, što će osigurati bolju učinkovitost i podnošljivost, smanjiti troškove zdravstvenog sustava te unaprijediti kvalitetu života onkoloških bolesnika. ]]></summary_hr><summary_en><![CDATA[Cancer is one of the greatest global health challenges. In modern oncology, treatment approaches are directed toward specific molecular targets. Targeted oral antitumor drugs, particularly kinase inhibitors and PARP inhibitors, have revolutionized treatment efficacy and tolerability compared to traditional cytotoxic therapy. However, a major drawback of these drugs is interindividual pharmacokinetic (PK) variability, which can lead to differences in efficacy and toxicity of the same dose among different patients. A potential solution to this issue is dose individualization based on drug exposure and patient-specific characteristics such as age, body weight, liver, and kidney function.The aim of this study is to develop innovative, green, automated, and miniaturized procedures for pre-analytical preparation of biological samples, as well as reliable, sensitive, and advanced analytical methods for determining patient exposure to targeted oral antitumor drugs. In addition to plasma samples as the gold standard, the potential of dried blood spot and saliva sampling will be investigated as less invasive, patient-friendly alternatives. To assess variability, an innovative approach using population PK models will be applied, facilitating the clinical interpretation of analytical results in the context of the patient’s overall health status. The significance of variability will be evaluated in terms of its frequency and impact on therapeutic efficacy and toxicity. Special attention will be given to the influence of metabolic interactions with other drugs and non-adherence on PK variability in real-world clinical practice.The proposed research is of key importance in understanding the clinical implications of variability in expensive, targeted antitumor drugs. It will enable the development of safer treatment protocols, ensuring better efficacy and tolerability, reducing healthcare system costs, and improving the quality of life for oncology patients.]]></summary_en></project><project>
<id>18277</id><title_hr><![CDATA[Pleiotropni pristup razumijevanju kardio-reno-metaboličkog zdravlja ]]></title_hr><title_en><![CDATA[Pleiotropic Approach to Understanding Cardio-Renal-Metabolic Health ]]></title_en><user_id>17833</user_id><user_firstLast_name>Andrea Gelemanović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2025-02</proposal_call><code>UIP-2025-02-9908</code><acronim><![CDATA[MultiOM4CRM]]></acronim><duration>01.04.2026 - 31.03.2031</duration><status>U tijeku</status><financ_value>274.467,00 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu]]></institution_hr><institution_en><![CDATA[University of Split]]></institution_en><team_members_id>870671, 870687, 865122, 25056, 19036, 870748, </team_members_id><team_members_names><![CDATA[Anita Jukić, Marijana Vučković, Dora Knezović, Maja Kuzman, Ivana Gunjača, Biljana Stanković, ]]></team_members_names><keywords_hr><![CDATA[kardio-reno-metabolički sindrom, pleiotropija, kronična upala povezana sa starenjem, sistemska biologija, personalizirana medicina]]></keywords_hr><keywords_en><![CDATA[cardio-reno-metabolic syndrome, pleiotropy, inflammaging, systems biology, personalized medicine]]></keywords_en><summary_hr><![CDATA[Kronične bolesti predstavljaju ogroman teret za javno zdravstvo, značajno utječu na kvalitetu života te dovode do prerane smrtnosti. Zbog sve starije populacije u Hrvatskoj i Europi, također se očekuje porast multimorbiditeta, te su prevencija i rana dijagnostika središnje teme nacionalnog i europskog znanstvenog interesa. Posebice, dijabetes tipa 2, kronična bubrežna bolest te kardiovaskularne bolesti su prepoznate kao jedne od najvećih javnozdravstvenih problema 21. stoljeća. Brojne epidemiološke studije ukazuju na snažnu povezanost između ovih bolesti koje dijele mnoge rizične čimbenike, poput debljine, povišenog krvnog tlaka, poremećaja masnoća u krvi, te kronične upale povezane sa starenjem, što je dovelo do definiranja objedinjujućeg pojma kardio-reno-metabolički sindrom. Iako je dobro poznato da su ova stanja povezana uz nepovoljan životni stil te su identificirani brojni molekularni markeri koji se povezuju uz navedene bolesti, ono što nedostaje je holistički pristup istraživanja multimorbiditeta i razumijevanje zajedničkih molekularnih mehanizama. Projekt MultiOM4CRM predstavlja inovativni i multidisciplinarni pristup s ciljem razumijevanja pleiotropnog učinka molekularnih rizičnih čimbenika koji dovode do razvoja multimorbiditeta te predstavlja iskorak u dosadašnjim istraživanjima jer će genetski i epigenetski profili biti integrirani u zajedničku mrežu po principima sistemske biologije i personalizirane medicine. Multidisciplinarnost se odražava i u sastavu istraživačkog tima koji će sačinjavati kliničari, molekularni biolozi i bioinformatičari čime će se ojačati suradnja između različitih ustanova i ekspertiza. Ovaj projekt istražuje novu paradigmu jer usmjerava istraživanje s pojedinačnih bolesti na sistemski pristup koji će omogućiti bolje razumijevanje molekularnih mehanizama multimorbiditeta, odnosno zašto se pojedine bolesti grupiraju zajedno, te će postaviti temelje za razvoj inovacija i primjenu razvijenih prediktivnih modela u kliničku primjenu.]]></summary_hr><summary_en><![CDATA[Noncommunicable diseases represent a significant public health burden, impacting quality of life and premature mortality. With aging population an increase in multimorbidity is anticipated, making prevention and early diagnosis a key scientific priority at the Croatian and European level. Specifically, type 2 diabetes, chronic kidney disease and cardiovascular diseases have been recognised as the greatest public health challenges of the 21st century. Numerous epidemiological studies indicate a strong link between these diseases, with shared risk factors such as obesity, high blood pressure, dyslipidaemia and inflammaging, leading to the definition of the unifying term cardio-renal-metabolic syndrome. Although it is well known that these conditions are linked to an unfavourable lifestyle and a numerous molecular markers have been associated with them, a holistic approach is lacking to study multimorbidity and to understand the common molecular mechanisms. MultiOM4CRM project represents an innovative and multidisciplinary approach aimed at understanding the pleiotropic effects of molecular risk factors leading to the development of multimorbidity and marks a breakthrough in current research. This will involve integrating genetic and epigenetic profiles into a shared network based on the principles of systems biology and personalised medicine. The multidisciplinary nature of the project is reflected in the composition of the research team, which will include clinicians, molecular biologists and bioinformaticians, strengthening collaboration between different institutions and areas of expertise. This project explores a new paradigm by shifting the research focus from individual diseases to a systemic approach, which will enable a better understanding of the molecular mechanisms of multimorbidity – specifically why certain diseases tend to group together – and will lay the foundation for the development of innovations and the clinical application of predictive models.]]></summary_en></project><project>
<id>18281</id><title_hr><![CDATA[MARICULTURE NETWORK: Implementation of new technologies for diversified sustainable aquaculture targeting healthy society and competitive regions -  MARINET]]></title_hr><title_en><![CDATA[]]></title_en><user_id>135</user_id><user_firstLast_name>Jelka Pleadin</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-7839</code><acronim><![CDATA[]]></acronim><duration>17.11.2025 - 17.11.2030</duration><status>U tijeku</status><financ_value>60,00 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Prehrambena tehnologija, </scie_field_hr><scie_field_en>Food technology, </scie_field_en><institution_hr><![CDATA[Hrvatski veterinarski institut]]></institution_hr><institution_en><![CDATA[Croatian Veterinary Institute]]></institution_en><team_members_id>872876</team_members_id><team_members_names><![CDATA[ Doktorand: Hanna Skendrović ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>18285</id><title_hr><![CDATA[Motivacije i prepreke za kolektivne akcije]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3880</user_id><user_firstLast_name>Renata Franc</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-3404</code><acronim><![CDATA[MOTIKA]]></acronim><duration>29.12.2025 - 28.12.2030</duration><status>U tijeku</status><financ_value>60,00 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Psihologija, </scie_field_hr><scie_field_en>Psychology, </scie_field_en><institution_hr><![CDATA[Institut društvenih znanosti Ivo Pilar]]></institution_hr><institution_en><![CDATA[Institute of Social Sciences Ivo Pilar in Zagreb]]></institution_en><team_members_id>873018</team_members_id><team_members_names><![CDATA[ Doktorand: Iva Sušilović ]]></team_members_names><keywords_hr><![CDATA[SIMCA model, doživljaj nepravde, efikasnost, identitet, normativne kolektivne akcije, nenormativne kolektivne akcije, nasilne i nenasilne KA]]></keywords_hr><keywords_en><![CDATA[SIMCA model, injustice,  efficacy, identity, normative collective action, nonnormative collective action, violent and peacefull collective action]]></keywords_en><summary_hr><![CDATA[Opći cilj projekta je utvrditi i istražiti motivacije i prepreke za sudjelovanje u različitim oblicima kolektivnih akcija (odnosno akcija radi unaprjeđenja interesa grupe ili zbog političke solidarnosti ) u hrvatskom kontekstu. Socijalno identitetski model KA kao tri temeljna motivatora KA ističe: izraženu socijalnu, osobito politiziranu identifikaciju, izraženi doživljaji nepravde te izraženu grupnu efikasnost. Usprkos brojnim potvrdama ovog i sličnih modela, ističe se i veći broj ograničenja, primjerice : zanemarivanje istraživanja sličnosti i razlika u motivatorima i preprekama za  sudjelovanje u različitim oblicima KA (npr. mirne ili nasilne),  zanemarivanje istraživanja različitih dimenzija doživljaja nepravde i percepcije efikasnosti, potom prepreka za sudjelovanjem u KA te uloge osobnih dispozicija. Projekt će koristi miješani istraživački pristup uz eksplorativno sekvencijalni nacrt . Prvo ćemo koristiti kvalitativnu metodu (polustrukturirani intervju s uzorkom građana N=25 i članova udruga N=25) pa kvantitativnu (online panel anketa u tri vala;  nacionalni reprezentativni kvotni uzorak s obzirom na dob, spol i obrazovanje: NT1 = 3120, NT2 = 1560, NT3 = 780) i prigodni uzorak članova udruga: NT1 = 1000, NT2 = 700, NT3 = 500). Prije prvog vala online anketiranja, provest ćemo dva pilot-istraživanja na prigodnim uzorcima studenata (N = 250 po istraživanju). Uz znanstveni doprinos, rezultati i spoznaje projekta imat će i  praktične implikacije za donositelje javnih politika (za programe i politike povezane sa poticanjem građanskog sudjelovanja te prevenciju nasilnih oblika kolektivnog djelovanja) te za voditelje i članove udruga (za privlačenje novih članova, mobilizaciju građana i članova kao i osnovu za eventualne prijedloge prema donositeljima javnih politika u smislu mogućih promjena za smanjivanje i uklanjanje prepreka za sudjelovanje u mirnim KA u hrvatskom kontekstu).]]></summary_hr><summary_en><![CDATA[The main goal of this project is to determine and investigate motivations and barriers for participation in different forms of collective actions (actions that are pursued with the aim of achieving group goals or political solidarity). The Social Identity Model of Collective Actions points out three fundamental motivators of CA: salient social and politicized identification, a strong feeling of injustice and strong group efficacy. Regardless of the rich empirical evidence for this and similar models, several limitations are highlighted, such as insufficient attention devoted to exploring the similarities and differences in motivators and barriers of different form of CA, to the determinants of nonparticipation – psychological barriers, different dimensions of the perceived injustice and efficacy and the potential role of dispositions. A mixed method approach and exploratory sequential design will be used, in which semi-structured interviews with participants from two samples (general public N=25; members of NGOs N025) will precede three wave online survey (nacional representative a quota sample NT1 = 3120, NT2 = 1560, NT3 = 780 and a convenient sample of members of NGOs members; NT1 = 1000, NT2 = 700, NT3 = 500). In addition to the common scientific knowledge, the project&#39;s results and expertise will be available for public policymakers to develop programs and policies related to encouraging citizen participation and preventing violent forms of CAs. NGO leaders and members will also be able to use the gained knowledge to attract new members and mobilize citizens and NGO members. Also, they will be able to use project findings in advocacy meetings with public policy makers when proposing ways to reduce and remove barriers to participation in peaceful CA in the Croatian context. ]]></summary_en></project><project>
<id>18291</id><title_hr><![CDATA[Kompleksi ciklopeptida s funkcionalnim ionima]]></title_hr><title_en><![CDATA[Cyclopeptide complexes with functional ions]]></title_en><user_id>12384</user_id><user_firstLast_name>Gordan Horvat</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-8238</code><acronim><![CDATA[CPepFunxIon]]></acronim><duration>09.12.2025 - 08.12.2028</duration><status>U tijeku</status><financ_value>199.900,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>7690, 865152, 22634, 3176, 2975, 26870, </team_members_id><team_members_names><![CDATA[Vladislav Tomišić, Matija Modrušan, Katarina Leko, Jiangyang You, Antonija Tomić, Giovanna Speranza, ]]></team_members_names><keywords_hr><![CDATA[ciklopeptidi, kompleksiranje, anioni, beta-laktamski antibiotici, fluorescentne boje, kolorimetrijske boje, anionski radikali]]></keywords_hr><keywords_en><![CDATA[cyclopeptides, complexation, anions, beta-lactam antibiotics, fluorescent dyes, colorimetric dyes, anion radicals]]></keywords_en><summary_hr><![CDATA[Razvoj anionskih receptora jedna je od ključnih tema supramolekulske kemije. U tom smislu, ciklopeptidi predstavljaju posebno zanimljivu klasu spojeva. Njihova sposobnost vezanja aniona proizlazi iz proton-donirajućih amidnih skupina, fleksibilnog makrocikličkog prstena i varijabilnosti peptidnih podjedinica.Ovaj projekt za cilj ima dizajn i sintezu ciklopeptida koji se sastoje od 4-6 aminokiselina, kao i termodinamičku, spektroskopsku i strukturnu karakterizaciju njihovih reakcija kompleksiranja s funkcionalnim anionima koji posjeduju specifična svojstva. To uključuje kolorimetrijske i fluorescentne boje, beta-laktamsku obitelj antibiotika i anionske radikale. Osim toga, transmembranski transport anorganskih aniona pomoću pripremljenih ciklopeptida biti će ispitan na sintetskim lipidnim vezikulama koje oponašaju biološke membrane. Također, utvrdit će se učinak kompleksiranja na hidrolitičku stabilnost i antibakterijsko djelovanje beta-laktama. Istraživani ciklopeptidi mogu se grupirati u četiri kategorije, ovisno o vrsti njihovih bočnih lanaca: alifatski, aromatski, hidrofilni i anion-koordinirajući. Koristit će se nekoliko eksperimentalnih metoda: ITC te spektroskopije NMR, UV-Vis, EPR, CD i fluorimetrija. Računalna karakterizacija bit će provedena pomoću MD simulacija i QM proračuna. Učinak solvatacije posebno će se istražiti provođenjem pokusa u vodenim otopinama, kao i protičnim i aprotonskim organskim otapalima.Očekuje se da će predložena istraživanja otvoriti nove mogućnosti u analitičkoj i medicinskoj uporabi proučavanih kompleksa, kao što su ciljana isporuka lijekova, povećanje stabilnosti i aktivnosti beta-laktamskih antibiotika i ekstrakcija aniona iz okoliša. Također, istraživani spojevi imaju potencijal za korištenje kao modelni sustavi za određivanje anionskih veznih mjesta u proteinima i proučavanju protein-protein interakcija.]]></summary_hr><summary_en><![CDATA[The development of anion receptors has been one of the key topics of supramolecular chemistry. In this respect, cyclopeptides represent a particularly interesting class of compounds. Their strong anion-binding abilities arise from the proton-donating amide groups, the flexible macrocyclic ring, and the variability of peptide subunits.This project aims towards design and synthesis of cyclopeptides comprising 4–6 amino acids as well as thermodynamic, spectroscopic, and structural characterization of their complexation reactions with functional anions possessing specific properties. These include colorimetric and fluorescent dyes, beta-lactam family of antibiotics, and anionic radicals. In addition, transmembrane transport of inorganic anions by the prepared cyclopeptides will be tested on the synthetic lipid vesicles mimicking biological membranes. The effect of complexation on beta-lactam hydrolytic stability and antibacterial activity will be determined as well. Cyclopeptides which will be investigated can be grouped into four categories related to the type of their side chains: aliphatic, aromatic, hydrophilic, and anion coordinating. Several experimental methods will be used, i.e. ITC and NMR, UV-Vis, EPR, CD, and fluorescence spectroscopies. The computational characterization will be carried out by MD simulations and QM calculations. Solvation effect will be particularly addressed by conducting the experiments in aqueous solutions as well as protic and aprotic organic solvents. It can be envisaged that the proposed investigations will open the new possibilities in analytical and medical use of the studied complexes, such as target drug delivery, increase of stability and activity of beta-lactam antibiotics, and anion extraction from the environment. Also, the investigated compounds have potential to serve as model systems for determination of anion-binding sites in proteins and studies of protein-protein interactions.]]></summary_en></project><project>
<id>18293</id><title_hr><![CDATA[Poluotok Pelješac - prirodni laboratorij za istraživanje dinamike prirodnih i umjetnih radionuklida u okolišu]]></title_hr><title_en><![CDATA[The Pelješac Peninsula - a natural laboratory for research on the dynamics of natural and artificial radionuclides in the environment]]></title_en><user_id>19525</user_id><user_firstLast_name>Ivana Tucaković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-1633</code><acronim><![CDATA[PP-LabNAR]]></acronim><duration>05.12.2025 - 04.12.2028</duration><status>U tijeku</status><financ_value>200.000,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Interdisciplinarne prirodne znanosti, Fizika, Geologija, Kemija, </scie_field_hr><scie_field_en>Interdisciplinary natural sciences, Physics, Geology, Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>19245, 3035, 19321, 19522, 868232, 865391, 5696, 23536, 19700, 2881, </team_members_id><team_members_names><![CDATA[Željko Grahek, Katja Magdić Košiček, Ivana Coha, Gorana Karanović, Martina Ivković, Tomislav Ilievski, Željka Zgorelec, Marija Galić, Delko Barišić, Božena Skoko, ]]></team_members_names><keywords_hr><![CDATA[Prirodna i umjetna radioaktivnost,  faktori prijelaza, alfa i gama spektrometrija, tekućinsko scintilacijsko brojanje, separacijske metode]]></keywords_hr><keywords_en><![CDATA[Natural and anthropogenic radioactivity, transfer factors, alpha and gamma spectrometry, liquid scintillation counting, separation methods]]></keywords_en><summary_hr><![CDATA[Praćenje dinamike radionuklida u okolišu izrazito je bitna tema zbog razumijevanja utjecaja na ekosustav te posljedično i na zdravlje čovjeka kroz njihov ulazak u hranidbeni lanac. Mjerenja radioaktivnosti tla na području poluotoka Pelješca u prethodnim istraživanjima pokazala su povišene aktivnosti pojedinih prirodnih (Ra-226, Po-210 i Pb-210) i umjetnih (Cs-137 i Sr-90) radionuklida u odnosu na ostatak Hrvatske. Uočena je usto i neravnoteža u lancu raspadnog niza uranija te prisustvo umjetnog radionuklida Am-241. Područje takvog radiološkog sastava nameće se stoga kao idealno za proučavanje vrlo kompleksnog pitanja dinamike radionuklida u okolišu i u sustavu tlo-biljka. Za to su potrebne sustavne analize sastava i fizikalno kemijskih karakteristika uzoraka tla, kao i prisutnih biljnih vrsta. S obzirom da dosadašnja istraživanja radioaktivnosti ovog područja nisu bila sustavna, a dosadašnji rezultati proizašli su iz ograničenog broja uglavnom stohastički uzetih uzoraka, ovim projektom želi se provesti sveobuhvatna analiza radioaktivnosti na Pelješcu. Time bi se dobila realna slika ovog specifičnog područja te ustanovilo podrijetlo kontaminacije radionuklidima s obzirom na geološku podlogu i klimatske procese.  Za vjerodostojne zaključke potrebno je mjerenja vršiti točnim i preciznim metodama, posebice u slučajevima vrlo niskih aktivnosti kakve se očekuju u uzorcima vegetacije. Stoga se ovim projektom planira i poboljšanje i implementacija prikladnih metoda određivanja alfa, beta i gama emitera.Proizašli rezultati i zaključci korisitit će široj znanstvenoj zajednici za razumijevanje dinamike radionuklida s obzirom na geomorfologiju i biogeokemijske procese u okolišu. S obzirom i na kontekst današnje svjetske geopolitike, razumijevanje utvrđenog utjecaja umjetnih radionuklida koristit će i za bolju pripremljenost u slučaju eventualnih budućih događaja kontaminacije za što će se moći primjenjivati ovim projektom razvijene metode.  ]]></summary_hr><summary_en><![CDATA[The monitoring of radioactivity in the environment is an extremely important issue for understanding the impact on the ecosystem and consequently on human health. Previous measurements of radioactivity in the soil on the Pelješac peninsula showed increased activities of certain natural (Ra-226, Po-210 and Pb-210) and artificial (Cs-137 and Sr-90) radionuclides compared to the rest of Croatia. A disequilibrium in the uranium decay chain and the presence of the artificial radionuclide Am-241 were detected, as well. The area with such a radiological composition is ideal for studying the very complex issue of dynamics of radionuclides in the environment and in the soil-plant system. This requires systematic analyzes of the composition and physico-chemical properties of the soil and plant species present. Previous studies of radioactivity in this area were not systematic and the results were based on a limited number of stochastically collected samples. Therefore, a comprehensive study of radioactivity on Pelješac is planned in order to obtain a realistic picture of this specific area and to determine the origin of radionuclides considering the geological basis and climatic processes.In order to obtain reliable conclusions, measurements must be carried out using accurate and precise methods, especially in the cases of very low levels of activity, expected in vegetation samples. Therefore, the improvement and implementation of suitable methods for the determination of alpha, beta and gamma emitters will be part of the project.The results and conclusions derived will be useful for scientific community to understand the dynamics of radionuclides with regard to geomorphology and biogeochemical processes in the environment. Considering current geopolitical situation, understanding the impact of anthropogenic radionuclides will also be useful to better prepare for possible future contamination events. The methods developed in this project could also be applied in such cases.]]></summary_en></project><project>
<id>18297</id><title_hr><![CDATA[Valorizacija proizvodnih ostataka iz tvornica ulja bazirana na konceptu biorafinerije]]></title_hr><title_en><![CDATA[]]></title_en><user_id>309</user_id><user_firstLast_name>Marina Tišma</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-9772</code><acronim><![CDATA[VALREO]]></acronim><duration>10.11.2025 - 09.11.2031</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Biotehnologija, </scie_field_hr><scie_field_en>Biotechnology, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Prehrambeno-tehnološki fakultet]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Food Technology]]></institution_en><team_members_id>872902</team_members_id><team_members_names><![CDATA[ Doktorand: Laura Hanić ]]></team_members_names><keywords_hr><![CDATA[proizvodni ostatci, proizvodnja biljnih ulja, valorizaija, visokovrijedni produkti, enzimi, analiza životkog vijeka]]></keywords_hr><keywords_en><![CDATA[residues, vegetable oil industry, valorisation, value-added products, enzymes, life cycle analysis ]]></keywords_en><summary_hr><![CDATA[Cilj ovog projekta je istražiti mogućnost transformacije postojećih uljara u biorafinerije na način da se proizvodni ostatci koriste za proizvodnju  proizvoda s dodanom vrijednošću i energiju, stvarajući kružnost životnog ciklusa resursa.Motivacija za ovo istraživanje leži u činjenici da je u Euoropskoj uniji u 2022. godini proizvedeno oko 16 milijuna tona biljnog ulja, a očekuje se da će se ta količina povećati na 17,5 milijuna tona do 2031. godine. Tijekom proizvodnje i rafiniranja ulja, dolazi do nastanka različitih vrsta proizvodnih ostataka, kao što su pogače sjemenki uljarica, iskorištena zemlja za izbjeljivanje, sapuni, destilati masnih kiselina, kiselo ulje i drugi.Prvo će se napraviti mapiranje tvornica ulja u Europi, u sklopu čega će se prikupiti podaci o dostupnosti, količini i trenutnom upravljanju proizvodnim ostatcima uljara. Optimizacijom i modeliranjem procesa proučavat će se različiti scenariji za prijelaz industrije ulja u integriranu biorafineriju. Zatim će se provesti istraživanje primjene a) naprednih termo-kemijskih metoda (osobito hidrotermalne obrade), b) bioloških metoda temeljenih na gljivama i c) sinergije dviju metoda korištenjem proizvodnih ostataka iz proizvodnje konopljinog, bučinog i lanenog ulje, posebice pogače, kao modelnih materijala. Tijekom tretmana proizvodit će se i karakterizirati različiti proizvodi, a kako bi se postigla kružnost procesa, istraživat će se mogućnost primjene nastalih proizvoda u različite svrhe. Na kraju će se provesti procjena životnog ciklusa (LCA) dobivenih proizvoda te će se analizirati i kvantificirati utjecaji korištenih tehnologija na okoliš.]]></summary_hr><summary_en><![CDATA[This project aims to explore the possibility of transforming existing vegetable oil industries (VOI) into biorefineries by converting process residues into new value-added products and energy, whereas creating the circularity in the life cycle of resources. The motivation for this research lays in the fact that the vegetable oil industry (VOI) in the EU produced approximately 16 million metric tons of oils in 2022 and this amount is expected to increase to 17.5 million metric tons by 2031. During the oil production and refining, various types of process residues are produced, such as oil seeds cakes (OC), spent bleaching earth (SBE), soapstocks, fatty acid distillates, acid oil, and others. Those materials are mostly unutilized. First, mapping of the VOI in the Europe will be performed, where the data on availability, quantity and current management of residues will be collected. Different scenarios for the transition of VOI into integrated biorefinery will be studied by optimisation approach and process modelling.?Then, an experimental research on a) advanced thermo-chemical methods, b) fungal-based biological methods, and c) synergy of two methods will be done using residual materials from the production of hemp, pumpkin, and flax oil, particularly oil cakes, as a model materials. During the treatment, a variety of the products will be produced and characterized. To close the loop, the advanced use of obtained products?for various applications will be investigated. At the end, a life cycle assessment (LCA) of obtained products will be performed and the environmental impacts of the used technologies will be analysed and quantified. ]]></summary_en></project><project>
<id>18303</id><title_hr><![CDATA[Otkrivanje neurorazvojne osnove Downovog sindroma pomoću jedinstvenih organoida ljudskog mozga]]></title_hr><title_en><![CDATA[]]></title_en><user_id>12653</user_id><user_firstLast_name>Dinko Mitrečić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-2561</code><acronim><![CDATA[DevDown]]></acronim><duration>15.11.2025 - 14.11.2031</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>872967</team_members_id><team_members_names><![CDATA[ Doktorand: Rafaela Filipan ]]></team_members_names><keywords_hr><![CDATA[Downov sindrom, kortikogeneza, diferencijacija neurona, sinaptogeneza, organoidi mozga, SOD1]]></keywords_hr><keywords_en><![CDATA[Down Syndrom, corticogenesis, neuronal differentiation, synaptogenesis, brain organoids, SOD1]]></keywords_en><summary_hr><![CDATA[Downov sindrom je najčešći kromosomski poremećaj u čovjeka i najčešći uzrok teških dijagnoza poput demencije i srčanih malformacija. Unatoč činjenici da su kod osoba s Downovim sindromom neke regije mozga manje, s plićim brazdama, u usporedbi s mozgom disomičnih osoba, još uvijek ne razumijemo razvojnu osnovu ovih malformacija. Praznine u našem znanju su primarno uzrokovane nemogućnošću modeliranja ljudske kortikogeneze na životinjskim modelima. Također, tkivo ljudskih zametaka je rijetko dostupno i donosi značajne varijabilnosti između uzoraka. Stoga je potreban posve nov metodološki pristup kako bismo razumjeli poremećen razvoj mozga kod Downovog sindroma.Naša grupa je uspostavila jedinstvene stanične linije od osobe koja je mozaik za Downov sindrom, tj. sve uočene razlike između trisomičnih i disomičnih stanica mogu se pripisati isključivo dodatnom setu kromosoma 21. Nadalje, uspostavili smo protokol uzgoja organoida mozga koji tijekom 100 dana diferencijacije razvijaju sve slojeve ljudske moždane kore. Budući da naši preliminarni podaci ukazuju na to da se trisomične stanice diferenciraju na drugačiji način, naša hipoteza je da je razvoj kore mozga kod Downovog sindroma poremećen, što također uključuje poremećeno formiranje sinapsi. U ovom projektu ćemo analizirati kako se trisomični neuroni diferenciraju i kako stvaraju sinapse tijekom razvoja slojeva moždane kore tijekom diferencijacije organoida. Budući da pretpostavljamo kako je gen SOD1 na 21. kromosomu jedan od glavnih uzroka ovih poremećaja, upotrijebit ćemo crispr tehnologiju kojom ćemo ukloniti treću kopiju SOD1 te promatrati mogu li se tako ispraviti neki od uočenih poremećaja.Ovaj projekt će unaprijediti razumijevanje razvojne osnove Downovog sindroma, ali i drugih stanja u kojima se mozak ne razvija normalno. Ako smanjeni broj kopija SOD1 poboljša kortikogenezu, to bi otvorilo mogućnost farmakološkog liječenja fetusa s ciljem smanjenja težine fenotipa ovog kromosomskog poremećaja.]]></summary_hr><summary_en><![CDATA[Down syndrome is the most common human chromosomal disorder and the most common cause of serious health problems like dementia and heart malformations. Despite the fact that in individuals with Down Syndrome some regions of brain are smaller with fewer sulci in comparison to the brains of disomic individuals, developmental basis of these malformations is not known. Lack of data is primarily caused by inability of modeling human corticogenesis in animal models. Moreover, human embryonic tissue is rarely accessible, and it brings inter-individual variability. Thus, we need a potent methodological breakthrough to understand brain development in Down Syndrome. Our group established unique cell lines from a person who is mosaic for Down Syndrome, ie. all observed differences between trisomic and disomic cells are attributed exclusively to additional set of chromosome 21. Moreover, we established protocol for organoids which during 100 days of differentiation develop all layers of human cortex. Since our preliminary data revealed that trisomic cells differentiate in a different pattern, our hypothesis is that development of the cortex in Down Syndrome is impaired, which as well includes perturbed formation of synapses. Thus we will perform analyses in which we will observe how do neurons differentiate and how do they make synapses during differentiation of trisomic organoids. Moreover, since we hypothesize that gene SOD1 at chr. 21 might be one of the major causes of these impairments, we will use crispr to remove the third copy of SOD1 and then observe if some of the impairments might be corrected in this way. This project will improve our understanding of developmental basis of Down syndrome, but as well of other conditions in which brain does not develop normally. If decreased number of copies of SOD1 improves corticogenesis, this might open up possibility to pharmacologically treat fetuses with the goal to reduce the severity of phenotype of this chromosomal disorder.]]></summary_en></project><project>
<id>18304</id><title_hr><![CDATA[Genski, laboratorijski, histološki i klinički prediktori ishoda bolesnika s IgA vaskulitisom]]></title_hr><title_en><![CDATA[]]></title_en><user_id>26821</user_id><user_firstLast_name>Marija Jelušić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-7915</code><acronim><![CDATA[IGAPREDICTORS]]></acronim><duration>15.11.2025 - 14.11.2025</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Clinical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>872966</team_members_id><team_members_names><![CDATA[ Doktorand: Hana Musil ]]></team_members_names><keywords_hr><![CDATA[ IgA vaskulitis, glomerulonefritis, biomarkeri, biopsija, histologija, djeca, ekspresija gena, alarmini]]></keywords_hr><keywords_en><![CDATA[IgA Vasculitis, Glomerulonephritis, Biomarkers, Biopsy, Histology, Children, Gene Expression, Alarmins]]></keywords_en><summary_hr><![CDATA[Ovaj je projekt nastavak prethodnog projekta HRZZ-a, IP-2019-04-8822, u čijem je fokusu i dalje najčešći vaskulitis u dječjoj dobi - IgA vaskulitis (IgAV) ili Henoch-Schönleinova purpura. U sklopu nacionalnog multicentričnog istraživanja u tri tercijarna pedijatrijska reumatološka i nefrološka centara nastavljamo istraživati kompleksnu patogenezu bolesti i njezine ishode. Cilj nam je prikazati kratkoročne i dugoročne ishode određenih podskupina bolesnika s IgAV-om, kao što su oni s perzistentnom izoliranom mikro ili makrohematurijom, onih s težim kožnim promjenama ili gastrointestinalnim manifestacijama, onih u kojih je IgAV započeo u kasnijoj dobi, kako bismo mogli definirati osobitosti u praćenju navednih podskupina bolesnika budući da još uvijek nisu poznati dugoročni ishodi takvih bolesnika te stoga nema preporuka kako ih pratiti. Nadalje, cilj nam je Istražiti mogućnost korištenja kalprotektina (S100A8/A9), proteina visoke pokretljivosti iz skupine 1 (HMGB1), IgA protutijela na ßII-spektrin (anti-SPTBN1 IgA), sindekana i glipikana kao biomarkera razvoja teže kliničke slike bolesti, nefritisa (IgAVN), aktivnosti upale i predskazatelja trajanja bubrežne bolesti. Ispitat ćemo ekspresiju gena sustavom NanoString u uzorcima kože i bubrega u djece s IgAV-om/IgAVN-om koja nisu liječena imunosupresivnom terapijom primjenom imunološkog panela gena te ekspresiju gena reguliranih interferonom tipa I u perifernoj krvi bolesnika kako bismo utvrdili mogu li nam dobivena saznanja pomoći u otkrivanju djece s rizikom za komplikacije IgAV-a. Očekujemo da će nam projekt pomoći u pravovremenom prepoznavanje djece s rizicima za komplikacije i planiranju personaliziranog pristupa liječenju. Nadamo se da će to pridonijeti prepoznavanju nezadovoljenih potreba bolesnika, a ujedno i osnažiti i konsolidirati međunarodnu istraživačku mrežu iz područja IgAV/IgAVN. ]]></summary_hr><summary_en><![CDATA[This project proposal is a continuation of the prior endeavor HRZZ project, IP-2019-04-8822, and remains focused on the most prevalent childhood vasculitis - IgA vasculitis (IgAV) or Henoch-Schönlein purpura. Spanning three tertiary pediatric rheumatology and nephrology centers nationally, our research perseveres in delving into the intricate pathogenesis of the disease and its outcomes. One of our primary objectives is to elucidate both short-term and long-term outcomes for specific subgroups of IgAV patients. These include those with persistent isolated micro- or macrohematuria, more severe skin changes, or gastrointestinal manifestations, along with individuals where IgAV onset occurred later in life. The goal is to define follow-up protocols for these subgroups since their long-term prognoses remain unknown, leading to a lack of established follow-up recommendations. Furthermore, we aim to explore the potential utility of calprotectin (S100A8/A9), high mobility group protein B1 (HMGB1), IgA antibodies to ßII-spectrin (anti-SPTBN1 IgA), syndecan, and glypican as biomarkers for predicting disease severity, nephritis (IgAVN), inflammatory activity, and the duration of kidney disease. Our investigation will involve analyzing gene expression using the NanoString system in skin and kidney samples from untreated children with IgAV/IgAVN, utilizing an immune gene panel. Additionally, we will assess the expression of genes regulated by type I interferon in patients&#39; peripheral blood to ascertain whether this knowledge aids in identifying at-risk children for IgAV complications. Anticipated outcomes of this project include the timely identification of high-risk children and the development of personalized treatment strategies. We aspire for our efforts to shed light on unmet patient needs while fortifying the international research network dedicated to IgAV/IgAVN.]]></summary_en></project><project>
<id>18308</id><title_hr><![CDATA[Procjena implementacije i učinkovitosti modela optimizacije terapije usmjerene na depreskripciju za starije osobe u domovima za starije i nemoćne]]></title_hr><title_en><![CDATA[Evaluating implementation and effectiveness of a deprescribing-focused therapy optimization model for older adults in nursing homes]]></title_en><user_id>865567</user_id><user_firstLast_name>Maja Ortner Hadžiabdić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-3772</code><acronim><![CDATA[DEPtoOLD]]></acronim><duration>05.12.2025 - 04.12.2028</duration><status>U tijeku</status><financ_value>89.470,00 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Javno zdravstvo i zdravstvena zaštita, Kliničke medicinske znanosti, Farmacija, </scie_field_hr><scie_field_en>Public health and health services, Clinical sciences, Pharmaceutical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Farmaceutsko-biokemijski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Pharmacy and Biochemistry]]></institution_en><team_members_id>867993, 867875, 867496, 867895, 24156, 12775, 868127, 868089, 867867, </team_members_id><team_members_names><![CDATA[Andrea Brajković, Slaven Falamić, Dora Belec, Ksenija Arbanas Kovačević, Nenad Bogdanovic, Robert Likić, Tajana Pavic, Jovan Mihajlović, Iva Bužančić, ]]></team_members_names><keywords_hr><![CDATA[depreskripcija, optimizacija farmakoterapije, stariji pacijenti, domovi za starije osobe, potencijalno neprikladni lijekovi]]></keywords_hr><keywords_en><![CDATA[deprescription, pharmacotherapy optimisation, older patients, nursing homes, potentially inappropriate medicines]]></keywords_en><summary_hr><![CDATA[Globalno starenje predstavlja ozbiljan društveni i zdravstveni izazov te postoji hitna potreba za pronalaženjem rješenja za prilagodbu zdravstvenih sustava i društva kako bi se adekvatno odgovorilo na potrebe starije populacije. Farmakoterapija je ključna u skrbi za starije bolesnike, ali istodobno nosi rizike zbog veće osjetljivosti starijih osoba na negativne učinke lijekova te čimbenika poput multimorbiditeta i politerapije. Naš projekt ima za cilj poboljšati ishode liječenja starijih bolesnika, putem racionalizacije farmakoterapije kao važnog aspekta skrbi za starije osobe. Planiramo razviti i procijeniti strategiju implementacije modela optimizacije farmakoterapije usmjerenog na depreskripciju kod korisnika domova za starije. Istraživanje će koristiti hibridni dizajn učinkovitosti-implementacije, kombinirajući kvantitativne i kvalitativne metode. Korištenjem okvira teorijskih domena (engl. Theoretical Domains Framework) i tehnika promjene ponašanja (engl. Behavior Change Techniques), te provođenjem fokus grupa s pružateljima zdravstvene skrbi u domovima za starije, identificirat ćemo ključne komponente implementacijske strategije. Razvit ćemo smjernice za depreskripciju utemeljene na dokazima, prilagođene potrebama zdravstvenih djelatnika u domovima za starije, te sveobuhvatan istraživački protokol. Konačno, provest ćemo klaster-randomizirano istraživanje kako bismo procijenili izvedivost i učinkovitost predložene intervencije, uzimajući u obzir saznanja iz ranijih faza projekta. Procijenit ćemo utjecaj intervencije na ishode, kao što su parametri sveobuhvatne gerijatrijske procjene, te na ekonomske aspekte. Rezultati istraživanja koristit će dionicima kao što su pružatelji zdravstvene skrbi, donositelji politika, te starije osobe i njihove obitelji. Ovo istraživanje trebalo bi dovesti do poboljšanja skrbi za pacijente i pružanja kvalitetnije zdravstvene usluge u domovima za starije, kao i do ušteda u zdravstvu.]]></summary_hr><summary_en><![CDATA[Global aging represents a significant social and health challenge, necessitating urgent solutions to adapt healthcare systems and society to adequately meet the needs of the older population. Pharmacotherapy is crucial in caring for older patients, but it also carries risks due to their increased susceptibility to the negative effects of medications and factors such as multimorbidity and polypharmacy. Our project aims to improve the outcomes in older patients by rationalizing pharmacotherapy as a crucial aspect of care of older patients. We plan to develop and evaluate an implementation strategy for deprescribing-focused pharmacotherapy optimisation in nursing home residents. The research will utilize a hybrid effectiveness-implementation study, combining quantitative and qualitative methods. By using the Theoretical Domains Framework and Behavior Change Techniques, and conducting focus groups with healthcare providers in nursing homes, we will identify key components of the implementation strategy. Evidence-based deprescribing guidelines tailored to the needs of healthcare providers in nursing homes will be developed, along with a comprehensive research protocol. Finally, we will conduct a cluster-randomized study to assess the feasibility and effectiveness of the proposed intervention, considering findings from earlier project phases. We will evaluate the impact of the intervention on outcomes such as comprehensive geriatric assessment parameters and economic aspects. The research findings will benefit stakeholders such as healthcare providers, policymakers, and older adults and their families. This research aims to improve patient care and provide higher quality healthcare in nursing homes, as well as contribute to healthcare cost savings.]]></summary_en></project><project>
<id>18309</id><title_hr><![CDATA[Učinkovitost konzervacijske poljoprivrede u ublažavanju klimatskih promjena kroz očuvanje tla i skladištenje ugljika]]></title_hr><title_en><![CDATA[The Effectiveness of Conservation Agriculture in Mitigating Climate Change through Soil Conservation and Carbon Storage]]></title_en><user_id>20372</user_id><user_firstLast_name>Danijel Jug</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-2870</code><acronim><![CDATA[CAREsoil]]></acronim><duration>01.12.2025 - 30.11.2028</duration><status>U tijeku</status><financ_value>196.000,00 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, Interdisciplinarne biotehničke znanosti, </scie_field_hr><scie_field_en>Agriculture, Interdisciplinary biotechnical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Fakultet agrobiotehničkih znanosti Osijek]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Agrobiotechnical Sciences in Osijek]]></institution_en><team_members_id>20373, 20374, 1289, 25960, 20421, 20436, 22803, 29289, 29290, 870295, 870297, 865146, 20435, 870107, 874037, </team_members_id><team_members_names><![CDATA[Irena Jug, Boris Đurđević, Bojana Brozović, Monika Marković, Vladimir Ivezić, Vladimir Zebec, Jurica Jović, Branka Šakić Bobić, Zoran Grgić, Marcela Andreata-Koren, Marijana Ivanek-Martinčić, Iva Rojnica, Marko Josipović, Ivana Dodlek Šarkanj, Vedran Lederer, ]]></team_members_names><keywords_hr><![CDATA[Konzervacijska poljoprivreda, konzervacijska obrada tla, klimatske promjene, degradacija tla, sekvestracija ugljika, ugljični otisak]]></keywords_hr><keywords_en><![CDATA[Conservation agriculture, Conservation soil tillage, Climate change, Soil degradation, Carbon sequestration, Carbon footprint]]></keywords_en><summary_hr><![CDATA[Konzervacijska poljoprivreda predstavlja ključnu strategiju u borbi protiv klimatskih promjena, prvenstveno kroz očuvanje tla i povećanje skladištenja ugljika. Ovaj projekt analizira učinkovitost metoda poput konzervacijske obrade tla, pokrivenosti tla biljnim ili žetvenim ostatcima i plodoreda u smanjenju emisije stakleničkih plinova i poboljšanju kvalitete i zdravlja tla. Navedene prakse imaju pozitivan učinak na proizvodna svojstva tla, smanjenje erozije, degradacije i emisije stakleničkih plinova. Kroz analizu postojećih i provedbu terenskih istraživanja, projekt će procijeniti doprinos konzervacijske poljoprivrede u sekvestraciji ugljika te njezin utjecaj na produktivnost i dugoročnu održivost poljoprivrednih sustava. Očekivani rezultati uključuju smanjenje emisija CO2, povećanu plodnost tla, bolju otpornost na ekstremne vremenske uvjete i dugoročne ekonomske koristi za poljoprivrednike. Projekt će pružiti smjernice za širu primjenu održivih praksi te podržati politike usmjerene na klimatski pametnu poljoprivredu.]]></summary_hr><summary_en><![CDATA[Conservation agriculture represents a key strategy in combating climate change, primarily through soil conservation and increased carbon storage. This project analyzes the effectiveness of methods such as conservation tillage, soil coverage with plant or crop residues, and crop rotation in reducing greenhouse gas emissions and improving soil quality and health. These practices have a positive impact on soil productivity, reducing erosion, degradation, and greenhouse gas emissions. Through the analysis of existing research and field studies, the project will assess the contribution of conservation agriculture to carbon sequestration and its impact on the productivity and long-term sustainability of agricultural systems. Expected outcomes include a reduction in CO2 emissions, increased soil fertility, improved resilience to extreme weather conditions, and long-term economic benefits for farmers. The project will provide guidelines for the broader adoption of sustainable practices and support policies aimed at climate-smart agriculture.]]></summary_en></project><project>
<id>18310</id><title_hr><![CDATA[Medicinske krize u Hrvatskoj u prvoj polovini 20. stoljeća]]></title_hr><title_en><![CDATA[Medical Crises in Croatia in the First Half of the 20th Century]]></title_en><user_id>304</user_id><user_firstLast_name>Martin Kuhar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-4618</code><acronim><![CDATA[KRIZUMED]]></acronim><duration>30.12.2025 - 29.12.2028</duration><status>U tijeku</status><financ_value>97.696,25 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Povijest, Etnologija i antropologija, </scie_field_hr><scie_field_en>History, Ethnology and anthropology, </scie_field_en><institution_hr><![CDATA[Hrvatska akademija znanosti i umjetnosti]]></institution_hr><institution_en><![CDATA[Croatian Academy of Sciences and Arts]]></institution_en><team_members_id>292, 23766, 20099, 19046, 868092, </team_members_id><team_members_names><![CDATA[Stella Fatović-Ferenčić, Jelena Seferović, Luka Pejić, Vedran Duančić, Marko Kolić, ]]></team_members_names><keywords_hr><![CDATA[geografija, invalidnost, kaznionice, povijest medicine, psihijatrija, studenti]]></keywords_hr><keywords_en><![CDATA[disability, geography, history of medicine, penitentiaries, psychiatry, students]]></keywords_en><summary_hr><![CDATA[Glavni istraživački cilj projekta jest identificirati strukturu i funkciju pojedinih kriza u medicini  tijekom prve polovine dvadesetog stoljeća u Hrvatskoj. Krize involviraju kompleksnu strukturu koja se sastoji od državne administracije, zdravstva kao sustava institucija, društvenih sastavnica i ekonomskih datosti, kao i dominantnih medicinskih paradigmi. Gledano vertikalno, krize se reflektiraju na razinama od najviših političkih struktura pa sve do individualnih sudbina, pritom nejednako zahvaćajući određene segmente populacije. U ovom projektu nastojat će se odgovoriti na pitanja poput: kako su krize galvanizirale modernizacijske procese i institucionalnu izgradnju zdravstvenog sustava?, kako su različiti akteri međusobno podupirali stanje kriza?, kako su se konstituirali otpori prema krizama, kao i prema predloženim rješenjima na krize?, itd. Projektni tim sastoji se od trojice povjesničara, dvoje liječnika/povjesničara medicine te etnologinje i kulturne antropologinje. Vedran Duančić će geografski odrediti institucionalne preduvjete za pojavu kriza, Martin Kuhar i Stella Fatović-Ferenčić istražiti rehabilitaciju ratnih vojnih invalida tijekom Prvoga svjetskog rata, Luka Pejić pojave i suzbijanje zdravstvenih kriza te biopolitički odnos prema tijelima zatvorenika u kaznionicama, Jelena Seferović strategije upravljanja i psihijatrijske prakse u kriznim razdobljima u Neuropsihijatrijskoj bolnici &#39;&#39;Dr. Ivan Barbot&#39;&#39; Popovača, Marko Kolić pritisak velikog broja ruskih studenata medicine poslije Oktobarske revolucije na Medicinski fakultet u Zagrebu, a viši asistent protuepidemijske mjere u Prvome i Drugome svjetskom ratu. Istraživači će krizama u medicini pristupiti ponajprije analizom arhivske građe, statističkih podataka i javnih glasila, kao i autobiografskih zapisa i memoara. U istraživanjima marginaliziranih skupina će se kroz davanje pozornosti svakodnevici i otporima odrediti uloga medicinskog znanja i zdravstvenog sustava u provedbi rješenja za krize.]]></summary_hr><summary_en><![CDATA[The main goal of the project is to identify the structure and function of individual medical crises in Croatia in the first half of the 20th century. Crises involve a complex structure consisting of state administration, healthcare as a system of institutions, social components, economic conditions, and dominant medical paradigms. Crises are reflected at the levels from the highest political structures all the way down to individual destinies, while unequally affecting certain segments of the population. In this project, we will try to answer questions such as: how did crises galvanize the institutional construction of the health system?, how did different actors mutually support the state of crisis?, how was resistance to crises constituted, as well as to proposed solutions to crises?, etc. The project team consists of three historians, two doctors/historians of medicine, and a cultural anthropologist. Vedran Duančić will geographically determine the institutional preconditions for the emergence of crises; Martin Kuhar and Stella Fatović-Ferenčić will investigate the rehabilitation of disabled soldiers during the First World War; Luka Pejić the emergence of health crises and the biopolitical relationship to the bodies of prisoners in penitentiaries; Jelena Seferović the management strategies and psychiatric practices during crises at the Neuropsychiatric Hospital in Popovača; Marko Kolić the pressure of a large number of Russian medical students after the October Revolution on the School of Medicine in Zagreb; and senior assistant the anti-epidemic measures in the First and Second World Wars. Researchers will primarily approach medical crises by analyzing archival material, statistical data and media, as well as autobiographical records and memoirs. In the research of marginalized groups, by paying attention to everyday life and resistance, the role of medical knowledge and the health system in the implementation of solutions to crises will be determined.]]></summary_en></project><project>
<id>18311</id><title_hr><![CDATA[Fenotipska plastičnost tijekom rane adaptivne evolucije primorske gušterice (Podarcis siculus)]]></title_hr><title_en><![CDATA[Phenotypic plasticity in the early adaptive evolution of Italian wall lizard (Podarcis siculus)]]></title_en><user_id>19008</user_id><user_firstLast_name>Anamaria Štambuk</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-6320</code><acronim><![CDATA[PLASTLIZ]]></acronim><duration>31.01.2026 - 30.01.2029</duration><status>U tijeku</status><financ_value>198.490,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>19712, 870416, 13161, 24034, 868140, 858354, 855417, 868038, 19725, </team_members_id><team_members_names><![CDATA[Anthony Herrel, Weizhao Yang, Duje Lisičić, Marko Glogoški, Vid Bakovic, Lucija Kanjer, Tomislav Gojak, Ivona Burić, Ivan Cizelj, ]]></team_members_names><keywords_hr><![CDATA[fenotipska plastičnost, plastičnost tranksriptoma, fiziološke adaptacije, pokus zajedničkog okoliša, adaptivna evolucija]]></keywords_hr><keywords_en><![CDATA[phenotypic plasticity, transcriptome plasticity, physiological adaptations, common garden experiment, adaptive evolution]]></keywords_en><summary_hr><![CDATA[Kada su organizmi izloženi promjeni okolišnih uvjeta, bilo u postojećem ili novom staništu, mogu postići fenotipsku prilagodbu genetskom evolucijom, fenotipskom plastičnošću, ili putem oba mehanizma. Plastične promjene osiguravaju brzu promjenu fenotipa potrebnu za početno preživljavanje, no dugotrajna opstojnost populacije učestalo ovisi o genetičkoj adaptaciji koja se može prenositi generacijama. Ta su dva procesa međusobno isprepletena, a plastičnost može olakšati ili otežavati genetičku evoluciju. Naša prijašnja istraživanja novo-uspostavljene populacije primorske gušterice (Podarcis siculus), koja se odlikuje značajnom ekološkom i morfološkom divergencijom u odnosu na predačku populaciju, pokazala su da i plastični i genetički procesi oblikuju ranu adaptivnu evoluciju. Nastavno na ta istraživanja, naša specifična istraživačka pitanja su: 1) Je li se i kako fenotipska plastičnost promijenila u novoj populaciji? 2) Je li promjena plastičnosti u novoj populaciji adaptivna? 3) Na koji način okolišni čimbenici uvjetuju fenotipsku plastičnost? Kako bismo odgovorili na ova pitanja, istražit ćemo fenotipsku divergenciju i usporediti fenotipsku plastičnost u novo-uspostavljenoj i predačkoj populaciji P. siculus na molekularnoj, fiziološkoj i morfološkoj razini. Kombinirat ćemo longitudinalna terenska istraživanja kvantifikacije fenotipskih odlika jedinki i okolišnih čimbenika, eksperimentalna izlaganja i pokuse križanja u zajedničkom okolišu, te analizu promjene ekspresije gena u odgovoru na manipulaciju okolišnih uvjeta. Rezultati ovog istraživanja unaprijedit će razumijevanje jednog od temeljnih evolucijskih pitanja – kako nastaju novi fenotipi, te će pružiti važna saznanja za ekologiju, invazivnu i konzervacijsku biologiju.]]></summary_hr><summary_en><![CDATA[When organisms are exposed to altered environmental conditions, either in an existing or new habitat, they can develop a novel beneficial phenotype via genetic evolution, phenotypic plasticity, or both. Plastic responses can provide the rapid phenotypic change needed to increase initial survival, but the long-term population persistence often relies on genetic adaptation that can be transmitted over generations. The two processes are highly intertwined, and plasticity can facilitate or hinder genetic evolution. Our preceding research on the case study of the newly established population of Italian wall lizard, Podarcis siculus, which exhibited significant ecological and phenotypic divergence from the ancestral population, have shown that both plastic and genomic processes shape its early adaptive evolution. Building on this work, our specific research questions are: 1) Whether and how was plasticity changed in the novel population? 2) Is the change of plasticity in the new population adaptive? 3) How does the environmental variation affect phenotypic plasticity? To tackle these questions, we will assess phenotypic divergence and compare phenotypic plasticity of P. siculus in the ancestral and new populations at the genomic, physiological, and morphological level. We will combine longitudinal field studies quantifying individual phenotypic data and environmental variance, experimental treatments and crossings in a common garden, with the transgenerational study of gene expression changes in response to environmental manipulation. The results of this study will improve our understanding of a fundamental evolutionary question - how novel phenotypes arise, and will also inform ecology, invasion and conservation biology.]]></summary_en></project><project>
<id>18320</id><title_hr><![CDATA[Kulinarske prakse, gospodarstvo i strategije korištenja zemljišta tijekom bakrenog doba u istočnoj Slavoniji]]></title_hr><title_en><![CDATA[]]></title_en><user_id>7519</user_id><user_firstLast_name>Ina Miloglav</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-5198</code><acronim><![CDATA[CULPLUS]]></acronim><duration>19.12.2025 - 18.12.2031</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Arheologija, </scie_field_hr><scie_field_en>Archeology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>29684</team_members_id><team_members_names><![CDATA[ Doktorand: Mia Marijan ]]></team_members_names><keywords_hr><![CDATA[arheologija, bakreno doba, arheometrija, keramika, iskorištavanje zemljišta]]></keywords_hr><keywords_en><![CDATA[archaeology, Copper Age, archaeometry, pottery, land-use]]></keywords_en><summary_hr><![CDATA[Cilj predloženog projekta je identificirati promjene u prehrambenim praksama u bakrenom dobu u istočnoj Slavoniji promatrane regionalno i dijakronijski, utvrditi eventualne uzroke promjena u prehrambenim aktivnostima i strategijama iskorištavanja biljaka i životinja te utvrditi na koji način se prilagodbe u prehrambenoj ekonomiji mogu povezati s društvenim i tehnološkim transformacijama. Kao predmet interesa odabran je geografski prostor između Vinkovaca-Đakova-Slavonskog Broda koji naseljavanjem obuhvaća razdoblje od srednjeg do kasnog bakrenog doba. Analize prehrambenih navika i kulinarskih praksi povezane su sa širim pitanjima upravljanja okolišem i strategijama korištenja zemljišta koje uključuju interdisciplinaran, sustavan i sistematičan metodološki pristup. Okosnicu istraživanja čini integrirani pristup projektnoj temi u kojem je svaki metodološki korak povezan horizontalno i vertikalno, a uključivat će funkcionalnu analizu lončarije (primarna klasifikacija, proučavanje tragova upotrebe, analize organskih ostataka i tehnološke analize), arheobotaničke (makro i mikrobotaničke) i palinološke analize, arheozoološke te radiokarbonske i analize stabilnih izotopa. Istraživački tim sastavljen od stručnjaka iz različitih znanstvenih disciplina (arheologija, geologija, kemija, biologija) svojim kompetencijama i iskustvom doprinijet će ostvarenju projektnih ciljeva, razvijajući nove teorije, spoznaje i modele društvene dinamike na promatranom području te uspostaviti znanstvene protokole za prikupljanje, pohranu i obradu podataka. S obzirom da je bakreno doba najslabije istražen prapovijesni period na području Hrvatske, te da raspolažemo s vrlo skromnim i oskudnim podacima, projektni rezultati koji uključuju integrirani metodološki pristup koji do sada nije primijenjen u Hrvatskoj popunit će praznine novim spoznajama o gospodarstvu, prehrambenim praksama, iskorištavanju zemljišta i prilagođavanju na okoliš tadašnjeg stanovništva.]]></summary_hr><summary_en><![CDATA[The proposed project aims to identify changes in dietary practices in the Copper Age in Eastern Slavonia, regionally and diachronically. It also aims to identify possible causes of changes in culinary activities and strategies for plant and animal exploitation and explore how adaptations in the food economy can be linked to social and technological transformations. The geographical area between Vinkovci, Đakovo, and Slavonski Brod was chosen as the research area, covering the period from the middle to late Copper Age. Analyses of dietary habits and culinary practices relates to wider issues of environmental management and land use strategies. necessitating an interdisciplinary, systematic, and methodological approach to research. The core of the research proposal is formed around an integrated approach to a project theme where each methodological step is linked horizontally and vertically and will include: functional analysis of pottery (primary classification, use-alteration analysis, organic residue analysis, and technological analysis); archaeobotanical (macro and microbotanical) and palynological analyses; archaeozoological, and stable isotope and the radiocarbon analyses. A research team composed of experts from different scientific disciplines (archaeology, geology, chemistry, biology) with its competencies and experience will contribute to the achievement of project objectives, developing new theories, insights, and models of social dynamics in the project area, and establish scientific protocols for data collection, storage, and processing. Given that the Copper Age has been the least researched prehistoric period in Croatia, and because we have very modest and scarce data, project results, including an integrated methodological approach that has not been applied so far in Croatia, will fill the gaps with new knowledge about the economy, food practices, land use and environmental adaptation of the population at that time.]]></summary_en></project><project>
<id>18322</id><title_hr><![CDATA[Od otpada od hrane do vanilina primjenom mikroreaktora]]></title_hr><title_en><![CDATA[From Food Waste to Vanillin Using Microreactors]]></title_en><user_id>6308</user_id><user_firstLast_name>Ana Jurinjak Tušek</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-1862</code><acronim><![CDATA[MicroVanillin]]></acronim><duration>05.12.2025 - 04.12.2028</duration><status>U tijeku</status><financ_value>199.849,00 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Interdisciplinarne biotehničke znanosti, Biotehnologija, Prehrambena tehnologija, Nutricionizam, </scie_field_hr><scie_field_en>Interdisciplinary biotechnical sciences, Biotechnology, Food technology, Nutrition, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Food Technology and Biotechnology]]></institution_en><team_members_id>6236, 12589, 6012, 1011, 5881, 870794, 870786, </team_members_id><team_members_names><![CDATA[Maja Benković, Tamara Jurina, Davor Valinger, Ksenija Durgo, Želimir Kurtanjek, Vesna Knights, Anka Trajkovska Petkoska, ]]></team_members_names><keywords_hr><![CDATA[bio-vanilin, ekstrakcija ferulinske kiseline, poljoprivredno-prehrambeni otpad, mikroreaktori u bioprocesiranju hrane, NIR spektroskopija ]]></keywords_hr><keywords_en><![CDATA[bio-vanillin, ferulic acid extraction, agro-food waste, microreactors in food bioprocessing, NIR spectroscopy]]></keywords_en><summary_hr><![CDATA[Cilj ovog projekta je razvoj održivog biološkog procesa proizvodnje vanilina putem enzimatske pretvorbe ferulinske kiseline, ključnog prekursora dobivenog iz poljoprivredno-prehrambenog otpada. Istraživanje se temelji na četiri ključna aspekta. Prvo, optimirati će se ekstrakcija ferulinske kiseline iz različitih izvora otpada korištenjem ultrazvučne, mikrovalne i enzimske ekstrakcije, uz detaljnu karakterizaciju pomoću HPLC-a i NIR spektroskopije. Drugo, fokus će biti na proizvodnji i karakterizaciji dvaju enzima, dekarboksilaze ferulinske kiseline (Fdc) i 4-vinilgvajakol oksigenaze (Cso2), u E. coli, čime će se omogućiti učinkovitija biokonverzija. Treće, istražit će se pretvorba ferulinske kiseline u vanilin u šaržnim reaktorima, s naglaskom na optimiranje procesa, kinetičko modeliranje i matematičku simulaciju. Konačno, enzimatska biokonverzija bit će implementirana u mikroreaktorski sustav kako bi se poboljšala učinkovitost reakcije, optimirali uvjeti kontinuiranog procesa te usporedila učinkovitost šaržnog i mikroreaktorskog procesa. Osim toga, razvijat će se kemometrijski modeli, uključujući PLS i ANN, za precizno predviđanje koncentracije vanilina na temelju NIR spektralnih podataka, čime će se poboljšati nadzor i kontrola procesa. Očekivani rezultati uključuju spektralne baze podataka s otvorenim pristupom, znanstvene publikacije i konferencijske prezentacije, čime će projekt doprinijeti razvoju održive proizvodnje vanilina iz obnovljivih izvora.]]></summary_hr><summary_en><![CDATA[This project focuses on the valorization of agro-food waste by developing a sustainable, bio-based approach for vanillin synthesis through the enzymatic conversion of ferulic acid, a key precursor derived from these waste sources. This research focuses on four main objectives. First, the extraction of ferulic acid from various agro-food waste materials will be optimized using ultrasound-assisted, microwave-assisted, and enzyme-assisted techniques, followed by characterization through HPLC and NIR spectroscopy. Second, the project will focus on the biosynthesis and characterization of two key enzymes, ferulic acid decarboxylase (Fdc) and 4-vinylguaiacol oxygenase (Cso2), in E. coli, enabling efficient bioconversion. Third, the transformation of ferulic acid into vanillin will be investigated in batch reactors, with emphasis on process optimization, kinetic modelling, and mathematical simulation. Finally, the enzymatic bioconversion will be integrated into a microreactor system to enhance reaction efficiency, optimize continuous-flow conditions, and compare the performance of batch and microreactor setups. Additionally, chemometric models, including PLS and ANN, will be developed to predict vanillin concentrations based on NIR spectral data, enabling improved process monitoring and control. This project is expected to yield valuable outcomes, including open-access spectral databases, scientific publications, and conference presentations, contributing to the advancement of a renewable and sustainable vanillin synthesis pathway.]]></summary_en></project><project>
<id>18324</id><title_hr><![CDATA[Istraživanje uporabe reprezentacija u nastavi fizike i matematike]]></title_hr><title_en><![CDATA[Exploring the use of representations in physics and mathematics education]]></title_en><user_id>23541</user_id><user_firstLast_name>Ana Sušac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-4569</code><acronim><![CDATA[REPRESENTATIONS]]></acronim><duration>15.01.2026 - 14.01.2029</duration><status>U tijeku</status><financ_value>135.125,00 eur</financ_value><scie_area_hr>Interdiciplinarne znanosti, Prirodne znanosti, </scie_area_hr><scie_area_en>Interdisciplinary scientific area, Natural sciences, </scie_area_en><scie_field_hr>Obrazovne znanosti, Matematika, Fizika, </scie_field_hr><scie_field_en>Educational sciences, Mathematics, Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>868385, 23543, 23490, 23643, 23550, 19829, 868386, 868393, </team_members_id><team_members_names><![CDATA[Petra Plavšić, Karolina Matejak Cvenic, Maja Planinić, Katarina Jeličić, Lana Ivanjek, Željka Milin Šipuš, Miroslawa Sajka, Roman Rosiek, ]]></team_members_names><keywords_hr><![CDATA[edukacijska fizika, edukacijska matematika, reprezentacije, mjerenje pokreta očiju, energijski dijagrami, dijagrami sila, funkcije]]></keywords_hr><keywords_en><![CDATA[educational physics, educational mathematics, representations, eye tracking, energy bar diagrams, free-body diagrams, functions]]></keywords_en><summary_hr><![CDATA[Reprezentacije su ključne u nastavi fizike i matematike jer učinkovito prenose složene koncepte. Vizualne reprezentacije, poput energijskih dijagrama i dijagrama sila, pomažu učenicima da razumiju probleme kvalitativno prije nego što prijeđu na jednadžbe i kvantitativna rješenja. U oba predmeta, učenici moraju prelaziti između verbalnih, grafičkih, algebarskih i numeričkih reprezentacija kako bi razvili dublje razumijevanje odnosa između varijabli. Ovaj projekt ima za cilj istražiti učeničku uporabu vizualnih reprezentacija u mehanici, procijeniti učinak istraživački usmjerene nastave uz vizualne reprezentacije na učeničko rješavanje problema i konceptualno razumijevanje te istražiti njihovo razumijevanje reprezentacija funkcija u matematici i fizici.Projekt će kombinirati tradicionalne metode, kao što su intervjui i testiranja, s mjerenjem pokreta očiju. Integrirajući kvantitativne podatke s kvalitativnim uvidima iz intervjua, dobit ćemo dublje razumijevanje načina na koji učenici koriste vizualne reprezentacije, poput energijskih dijagrama, dijagrama sila i reprezentacija funkcija, za rješavanje problema u fizici i matematici. Rezultati će pružiti vrijedne uvide u učeničke kognitivne procese, strategije rješavanja problema i učinkovitost istraživački usmjerene nastave u jačanju konceptualnog razumijevanja.Očekuje se da će ovo istraživanje imati značajan utjecaj na STEM obrazovanje unapređujući kako znanstvene spoznaje, tako i nastavne prakse. Rezultati će izravno utjecati na nastavu nudeći preporuke temeljenje na rezultatima istraživanja za korištenje vizualnih reprezentacija u nastavi fizike i matematike. Osim toga, projekt će razviti istraživači usmjerenu nastavnu sekvencu o energiji koju nastavnici mogu uključiti u svoju praksu, poboljšavajući učeničko razumijevanje ovog ključnog koncepta u fizici i modernom društvu. Na kraju, ovi će rezultati pomoći u razvoju učinkovitijih nastavnih metoda u STEM obrazovanju koje su utemeljene na istraživanjima.]]></summary_hr><summary_en><![CDATA[Representations are crucial in teaching physics and mathematics by effectively communicating complex concepts. Visual representations, such as energy bar and free-body diagrams, help students understand problems qualitatively before transitioning to equations and quantitative solutions. In both subjects, students must switch between verbal, graphic, algebraic, and numeric representations to develop a deeper understanding of relationships between variables. This project aims to investigate students&#39; use of visual representations in mechanics, evaluate the impact of inquiry-based teaching with visual representations on their problem-solving and conceptual understanding, and explore their understanding of function representations in mathematics and physics. The project will combine traditional methods, such as interviews and testing, with eye-tracking techniques. By integrating quantitative data with qualitative insights from interviews, we will gain a deeper understanding of how students use visual representations, such as energy bar diagrams, free-body diagrams, and function representations, to solve problems in physics and mathematics. The findings will provide valuable insights into students&#39; cognitive processes, problem-solving strategies, and the effectiveness of inquiry-based teaching methods in enhancing conceptual understanding.This research is expected to have a significant impact on STEM education by advancing both scientific knowledge and teaching practices. The findings will directly inform teaching by offering evidence-based recommendations for using visual representations in physics and mathematics education. Additionally, the project will develop an inquiry-based teaching sequence on energy that teachers can incorporate into their practice, improving students&#39; understanding of this key concept in physics and modern society. Ultimately, these outcomes will support the development of more effective, research-based teaching methods in STEM education.]]></summary_en></project><project>
<id>18328</id><title_hr><![CDATA[Integracija, testiranje i optimizacija homogenog elektromagnetskog kalorimetra]]></title_hr><title_en><![CDATA[Integration, testing, and optimization of the homogeneous electromagnetic calorimeter]]></title_en><user_id>7481</user_id><user_firstLast_name>Marko Kovač</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-6643</code><acronim><![CDATA[ECAL-BOOST]]></acronim><duration>29.01.2026 - 28.01.2029</duration><status>U tijeku</status><financ_value>188.453,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, Interdisciplinarne prirodne znanosti, </scie_field_hr><scie_field_en>Physics, Interdisciplinary natural sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Science]]></institution_en><team_members_id>870898, 870887, 870780, </team_members_id><team_members_names><![CDATA[Stefano Argiro&amp;#39;, Francesca Cavallari, David Petyt, ]]></team_members_names><keywords_hr><![CDATA[nadogradnja elektronike, DAQ testiranje, DQM validacija, L1 trigger analiza, spike-killer optimizacija]]></keywords_hr><keywords_en><![CDATA[electronics upgrade, DAQ testing, DQM validation, L1 trigger analysis, spike-killer optimization]]></keywords_en><summary_hr><![CDATA[Elektromagnetski kalorimetar (ECAL) Kompaktnog mionskog solenoida (CMS) na Velikom hadronskom sudaraču (LHC) u CERN-u sastoji se od više od 75.848 kristala olovnog volframata (PbWO4), dizajniranih za visokoprecizna mjerenja energije. S prijelazom LHC-a u fazu visokog luminoziteta (HL-LHC), trenutna luminozitet će se povećati, a broj istovremenih proton-proton međudjelovanja porast će sa 60 na maksimalnih 200. Kako bi se uspješno nosili s povećanim razinama zračenja, front-end elektronika kao i elektronika izvan detektora moraju biti nadograđene. Novi sustav predpojačala smanjit će curenja struje lavinskih fotodioda (APD) uzrokovano zračenjem, dok će ADC s preduzorkovanjem na 160 MHz prenositi podatke u streaming načinu rada uz kompresiju podataka bez gubitaka. Ova nadogradnja će ublažiti starenje kalorimetra, istovremeno zadržavajući izvrsnu rezoluciju energije i uvodeći mogućnosti preciznog mjerenja vremena koja se može koristiti za ublažavanje komplikacija uzrokovanih istovremenim proton-proton međudjelovanjima i preciznu lokalizaciju verteksa Higgsovog bozona u raspadu na dva fotona.Prema trenutnom rasporedu, ECAL supermoduli (SM) će biti uklonjeni iz CMS detektora početkom 2027. godine i ponovo umetnuti početkom 2028. Plan za 2025–2026. uključuje rad na testnom supermodulu 36 kao obuku za zamjenu elektronike. Također će započeti razvoj softverskih modula za prikupljanje podataka (DAQ), zajedno sa modulima za testiranje različitih elektroničkih elemenata, kao što su trigger tornjevi i moduli. Kvaliteta prikupljenih testnih podataka mora biti temeljito verificirana, što zahtijeva razvoj softvera za praćenje kvalitete podataka (DQM). Ključni zadaci uključivat će mjerenje transparentnosti kristala, mjerenja pedestala i druge dijagnostičke procese. U posljednjoj fazi, fokus će biti na razvoju i optimizaciji spike-killer algoritma kako bi se uklonili signali nastali direktnom ionizacijom APD-ova, podršci integraciji elektronike i puštanju detektora u rad.]]></summary_hr><summary_en><![CDATA[The Electromagnetic Calorimeter (ECAL) of the Compact Muon Solenoid (CMS) at CERN’s Large Hadron Collider (LHC) consists of over 75,848 lead tungstate (PbWO4) crystals, designed for high-precision energy measurements. With the LHC transitioning to the High-Luminosity phase (HL-LHC), the instantaneous luminosity will increase, and the number of concurrent proton-proton collisions per bunch crossing will rise from 60 to a maximum of 200. To manage the increased event complexity and higher radiation levels, the ECAL front-end and off-detector electronics must be upgraded. The new pre-amplifier will mitigate the radiation-induced increase in Avalanche Photodiodes (APD) leakage current, while an ADC with 160 MHz oversampling will transmit data in streaming mode to the off-detector electronics with lossless data compression. This upgrade will counteract calorimeter aging while maintaining excellent energy resolution and introducing precision timing capabilities, which can be utilized for pileup mitigation and precise Higgs boson vertex localization in its two-photon decay channel.According to the current schedule, the ECAL supermodules (SM) will be removed from the CMS detector in early 2027 and reinserted in early 2028. The 2025–2026 plan includes work on test supermodule 36 as training for the replacement of electronics. Additionally, the development of Data Acquisition (DAQ) software modules will begin, alongside software modules for testing various electronic subsystems, including trigger towers and modules. The quality of the collected test data must be thoroughly verified, requiring the development of Data Quality Monitoring (DAQ) software. Key tasks will include measuring crystal transparency, pedestal measurements, and other diagnostic processes. In the final phase, the focus will shift to development and optimization of the spike-killer algorithm to reject signals from direct ionization of APDs by hadrons, supporting electronics integration, and commissioning.]]></summary_en></project><project>
<id>18329</id><title_hr><![CDATA[Razvoj naprednih tehnika za otpornost povijesne i nedovoljno istražene sakralne arhitekture]]></title_hr><title_en><![CDATA[Advanced Resilience Techniques for Historical and Understudied Sacral Architecture]]></title_en><user_id>19909</user_id><user_firstLast_name>Mislav Stepinac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-4892</code><acronim><![CDATA[ARTHUR]]></acronim><duration>30.12.2025 - 29.12.2028</duration><status>U tijeku</status><financ_value>200.000,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Građevinarstvo, Arhitektura i urbanizam, Temeljne tehničke znanosti, Interdisciplinarne tehničke znanosti, </scie_field_hr><scie_field_en>Civil engineering, Architecture and Urban Environment, Basic engineering sciences, Interdisciplinary technological sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Građevinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Civil Engineering]]></institution_en><team_members_id>17806, 3063, 861469, 868407, 870803, 870820, 870841, 870822, 870693, 870851, 870860, 870861, 867499, 4213, 870899, 870932, 865235, 870839, 871000, 23328, 26414, 873432, </team_members_id><team_members_names><![CDATA[Martina Grubor, Davorin Penava, Karlo Ožić, Javier Ortega, Savvas Saloustros, Marco Francesco Funari, Tiago Ferreira, Chiara Ferrero, Chiara Bedon, Natasa Ivanisevic, Onur Kaplan, Gordana Kaplan, Lucija Stepinac, Josip Galić, Marieta Nunez Garcia, Krunoslav Šmit, Antonela Moretić, Milan Domazet, Monika Pranjić, Trpimir Vedriš, Ivan Hafner, Anja Majurec, ]]></team_members_names><keywords_hr><![CDATA[sakralna baština, potres, ziđe, oštetljivost, ranjivost, crkve, 3D printanje, ekspeditivna metoda]]></keywords_hr><keywords_en><![CDATA[sacral architecture, Earthquake, Masonry, Fragility, Vulnerability, 3D printing, expeditious method]]></keywords_en><summary_hr><![CDATA[Projekt ARTHUR osmišljen je kako bi unaprijedio znanje o otpornosti sakralne arhitekture kroz interdisciplinarni pristup, integrirajući konstrukcijske, društvene i tehnološke analize. Istraživanje će biti podijeljeno u četiri radne skupine s fokusom na specifične aspekte seizmičke otpornosti, procjenu ranjivosti (oštetljivosti), društveno-povijesni kontekst i digitalnu reprezentaciju. Seizmička otpornost procjenjivat će se prikupljanjem podataka iz projekata obnove i dostupnih baza podataka. Mehanička svojstva nearmiranog ziđa klasificirat će se korištenjem postojećih rezultata te in situ ispitivanjima ravnim prešama, MQI metoda će biti primijenjena za svaku građevinu i na kraju projekta biti prilagođena za hrvatsku tipologiju. Izrađeni linearni i nelinearni modeli bit će validirani na temelju stvarnih oštećenja i dinamičkih podataka konstrukcija. Razvit će se ekspeditivna metoda procjene seizmičke oštetljivosti temeljena na makroseizmičkim pristupima i složenim statističkim analizama. Dobiveni rezultati će se koristiti za preciznije određivanje težinskih faktora parametara oštetljivosti. Društvena, povijesna i etnografska važnost crkava istražit će se terenskim radom i uključivanjem lokalnih zajednica. Provodit će se intervjui kako bi se steklo razumijevanje lokalnih percepcija rizika, vrijednosti baštine i značaja crkava za lokalne zajednice. Arhitektonske, umjetničke i urbanističke karakteristike biti će pomno proučene, a prikupljeni podaci doprinijet će sveobuhvatnom okviru za procjenu oštetljivosti.Digitalizacija će igrati važnu ulogu u vizualizaciji i diseminaciji. 3D ispisani modeli bit će izrađeni kako bi ilustrirali izvorne konstrukcije i rješenja za pojačanje. ]]></summary_hr><summary_en><![CDATA[The ARTHUR project is designed to enhance knowledge on the resilience of sacral architecture through an interdisciplinary approach, integrating structural, social, and technological analyses. The research will be divided into four working groups, each focusing on specific aspects of seismic resilience, vulnerability assessment, socio-historical context, and digital representation. Seismic resilience will be evaluated by collecting data from renovation projects and available databases. The mechanical properties of unreinforced masonry will be classified using existing results and in situ testing with flat jacks. The MQI method will be applied to each building and, and, by the end of the project, adapted to the Croatian typology. Developed linear and nonlinear models will be validated based on actual damage and structural dynamic data. A rapid seismic vulnerability assessment method will be developed based on macroseismic approaches and advanced statistical analyses. The obtained results will be used to refine the weighting factors for vulnerability parameters. The social, historical, and ethnographic significance of churches will be explored through fieldwork and engagement with local communities. Interviews will be conducted to understand local perceptions of risk, heritage values, and the importance of churches to their communities. Architectural, artistic, and urban characteristics will be carefully studied, and the collected data will contribute to a comprehensive vulnerability assessment framework. Digitalization will play a significant role in visualization and dissemination, with 3D printing as a key tool for representing structural analyses and retrofitting solutions. High-resolution 3D-printed models will be created to illustrate original structures, damage patterns, and proposed reinforcement techniques, providing tangible insights into the seismic behavior and restoration strategies of sacral architecture.]]></summary_en></project><project>
<id>18330</id><title_hr><![CDATA[Genetic diagnosis of kidney and urinary tract malformations]]></title_hr><title_en><![CDATA[]]></title_en><user_id>12479</user_id><user_firstLast_name>Katarina Vukojević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-5546</code><acronim><![CDATA[NEPHROGEN]]></acronim><duration>04.12.2025 - 04.12.2031</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Split School of Medicine]]></institution_en><team_members_id>872937</team_members_id><team_members_names><![CDATA[ Doktorand: Tomislav Rakić ]]></team_members_names><keywords_hr><![CDATA[CAKUT, bubreg, genetika, razvoj, WES]]></keywords_hr><keywords_en><![CDATA[CAKUT, kidney, genetics, development, WES]]></keywords_en><summary_hr><![CDATA[Malformacije bubrega i mokraćnog sustava uključuju različite anatomske fenotipove, kao što su agenezija/displazija bubrega, hipoplazija, opstrukcija ureteropelvičnog spoja, vezikoureteralni refluks ili duplicirani ureter i opisani su pod akronimom CAKUT (kongenitalne anomalije bubrega i urinarnog trakta). Ove se malformacije javljaju u polovici pedijatrijskih i 7% odraslih osoba s krajnjim stadijem zatajenja bubrega diljem svijeta i imaju značajan utjecaj na dugoročno preživljenje pacijenata. Genetski čimbenici igraju ključnu ulogu u razvoju CAKUT-a. Međutim, stopa sporadičnih slučajeva koji se objašnjavaju visoko penetrantnim mutacijama u jednom genu možda je bila precijenjena tijekom godina i genetska dijagnoza je u većini slučajeva propuštena. Oko 20% pacijenata može imati genetski poremećaj koji se ne otkriva standardnim kliničkim pregledima, što implicira druge različite mutacijske mehanizme i patogentske putove. Do 15% slučajeva CAKUT-a ima genetski poremećaj za koji se sumnja da uzrokuje neurokognitivno oštećenje i čije rano prepoznavanje može utjecati na kliničku skrb. Uz to, malformacije bubrega i mokraćnog sustava često su prva klinička manifestacija složene sistemske bolesti, stoga rana molekularna dijagnoza može pomoći liječniku da identificira druge subkliničke manifestacije. Fenotipska i etiološka heterogenost CAKUT-a predstavlja značajnu prepreku kliničkom i temeljnom ispitivanju. Stoga je glavni imperativ dobiti uvid u identificiranje novih genetskih pristupa koji mogu pomoći u razotkrivanju genetske arhitekture i primarnih molekularnih defekata koji leže u pozadini CAKUT-a, kako bi se omogućila ispravna dijagnoza, utvrdila prognoza i na kraju razvili učinkoviti modaliteti prevencije i liječenja. Očekuje se da će ovaj projekt identificirati nove gene koji predisponiraju malformacije bubrega i mokraćnog sustava korištenjem visokoučinkovitih genomskih tehnologija kako bi se provela identifikacija gena i početna funkcionalna karakterizacija.]]></summary_hr><summary_en><![CDATA[Kidney and urinary system malformations include different descriptive anatomic phenotypes, such as kidney agenesis/dysplasia, hypoplasia, ureteropelvic junction obstruction, vesicoureteral reflux or duplicated ureter and are described under acronim CAKUT (congenital anomalies of kidneys and urinary tract) (1, 2). These malformations occur in 40-50% of pediatric and 7% of adult end-stage kidney failure worldwide, and they have significant impact on long-term patient survival (1-3). Genetic factors play a key role in the development of kidney and urinary system malformations (4). However, the rate of sporadic CAKUT cases explained by highly penetrant mutations in a single gene may have been overestimated over the years and a genetic diagnosis is missed in most cases (2). Additionally, approximately 20% of patients may have a genetic disorder that is not detected with standard clinical examinations, implying other different mutational mechanisms and pathogenic pathways (3). In particular, up to 15% of CAKUT cases have an unsuspected genomic disorder causing neurocognitive impairment and whose early recognition can impact clinical care (3). Therefore, the importance of identifying new genetic approaches that can help unraveling the genetical architecture of unexplained CAKUT cases is imperative. Additionally, kidney and urinary system malformations are often the first clinical manifestation of a complex systemic disease, therefore, an early molecular diagnosis can help the physician to identify other subclinical manifestations and provide better treatment of patients. ]]></summary_en></project><project>
<id>18331</id><title_hr><![CDATA[AIFORS - ERA Chair in Artificial Intelligence for Robotics]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4132</user_id><user_firstLast_name>Ivan Marković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-5149</code><acronim><![CDATA[]]></acronim><duration>19.12.2025 - 18.12.2031</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>867621</team_members_id><team_members_names><![CDATA[ Doktorand: Anja Delić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>18344</id><title_hr><![CDATA[Izotopni otisak stratificiranog morskog jezera (Zmajevo oko)]]></title_hr><title_en><![CDATA[]]></title_en><user_id>287</user_id><user_firstLast_name>Irena  Ciglenečki-Jušić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-4604</code><acronim><![CDATA[ISO-ZOKO]]></acronim><duration>09.01.2026 - 08.01.2031</duration><status>U tijeku</status><financ_value>60,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Interdisciplinarne prirodne znanosti, </scie_field_hr><scie_field_en>Interdisciplinary natural sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>872986</team_members_id><team_members_names><![CDATA[ Doktorand: Luka Andrijanić ]]></team_members_names><keywords_hr><![CDATA[stabilni izotopi, organska tvar, CNS omjer, stratifikacija, morsko jezero, Rogozničko jezero-Zmajevo oko ]]></keywords_hr><keywords_en><![CDATA[stable isotopes, organic matter, CNS ratio, stratification, sea lake, Rogozničko lake-Zmajevo oko]]></keywords_en><summary_hr><![CDATA[Projekt ISO-ZOKO, kao prošireni nastavak projekta MARRES, ima za cilj istražiti varijabilnost sastava stabilnih izotopa (13C, 15N, 34S) i C/N/S omjera organske tvari (OT) u različitim vodenim slojevima morskog sustava Rogozničkog jezera (RL) – Zmajeva oka, s posebnim osvrtom na hipooksigenirani epilimnion te euksinski sloj kemokline i monimolimniona. Stabilni izotopi će se proučavati zajedno s drugim relevantnim pokazateljima podrijetla i sudbine OT s obzirom na fizikalno-kemijsku stabilnost vodenog stupca RL i moguće vlažne i suhe unose oborinom, putem peludi, površinskog otjecanja i krške podzemne vode. Glavni cilj projekta je razlikovati različite alohtone i autohtone izvore i karakteristike OT u ovom stratificiranom i eutrofnom morskom okolišu. Važan cilj, ali i ishod projekta je postavljanje stalne motriteljske stanice s data loggerima za kontinuirano mjerenje fizikalno-kemijskih parametara (T, S, O2, pH) visoke prostorne i vremenske rezolucije u centru jezera, nad njegovom najdubljom točkom. Mjerna postaja bit će važan izvor podataka za praćenje suptilnih promjena u raslojenosti vodenog stupca u kontekstu ovog projekta, ali i u budućnosti za sve zainteresirane za limnološka i/ili istraživanja promjenjivih uvjeta okoliša. Ovakva istraživanja u vrijeme intenzivnih klimatskih i ekoloških promjena imaju vrlo važan lokalni, ali i širi znanstveni utjecaj.Rezultati projekta značajno će doprinijeti: 1) poznavanju izvora, sudbine i ciklusa OT u obalnim sredinama kao što su plitki zaljevi, lagune i morska jezera, kao i 2) sustavnom praćenju, održivom korištenju, zaštiti i upravljanju takvim okolišem, a posebno zaštiti ovog klimatskim promjenama i antropogenim utjecajima ugroženom sustavu jadranske obale. Važan doprinos projekta je i u jačanju istraživačkih kapaciteta i suradnje unutar komplementarne i interdisciplinarne istraživačke grupe, uključujući osposobljavanje i obrazovanje mladih znanstvenika.]]></summary_hr><summary_en><![CDATA[The ISO-ZOKO project, as an extended continuation of the MARRES project, aims to investigate the variability of stable isotope signatures (13C, 15N, 34S) and C/N/S ratios of organic matter (OM) in different water layers of the Rogoznica Lake (RL) - Zmajevo oko marine system, with special focus on the hypooxygenated epilimnion and the euxinic chemocline and monimolimnion. Stable isotopes will be studied together with other relevant proxies as indicators of the origin and fate of OM with respect to the physico-chemical stability of the RL water column and possible wet and dry inputs from precipitation, pollen, surface runoff and karst groundwater. The main objective is to distinguish between different allochthonous and autochthonous sources and characteristics of OM in this highly stratified marine environment. An important goal, but also the outcome of this project, is the installation of a permanent station for continuous monitoring of the physico-chemical parameters (T, S, O2, pH) with high spatial and temporal resolution in the centre, above the deepest point of the lake. The measuring station will be an important data source for monitoring subtle changes in the stratification of the water column not only within this project, but also in the future for all those interested in limnological and/or research on changing environmental conditions. Such research in times of intense climatic and ecological change has a very important local but also broader scientific impact.The project results will contribute significantly to the knowledge of the sources, fate and cycling of OM in coastal environments such as shallow bays, lagoons and marine lakes, as well as to the systematic monitoring, sustainable use, protection and management of RL and similar marine systems. An important contribution is seen in the strengthening of research capacity and collaboration within the complementary and interdisciplinary research group, including the training of young researchers.]]></summary_en></project><project>
<id>18350</id><title_hr><![CDATA[Društvena kritičnost suvremenog hrvatskog romana]]></title_hr><title_en><![CDATA[Social Criticism in Contemporary Croatian Novels]]></title_en><user_id>870116</user_id><user_firstLast_name>Mario Kolar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-8606</code><acronim><![CDATA[SCCCN]]></acronim><duration>12.01.2026 - 11.01.2029</duration><status>U tijeku</status><financ_value>161.474,50 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filologija, </scie_field_hr><scie_field_en>Philology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Filozofski fakultet u Rijeci]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>870138, 8564, 1368, 19173, 874118, </team_members_id><team_members_names><![CDATA[Sanjin Sorel, Anera Ryznar, Saša Stanić, Dejan Durić, Marko Gregur, ]]></team_members_names><keywords_hr><![CDATA[suvremeni hrvatski roman, postjugoslavenski roman, društvena kritika, medijska recepcija književnosti, suvremena književna i kulturna teorija]]></keywords_hr><keywords_en><![CDATA[contemporary Croatian novel, post-Yugoslav novel, social criticism, media reception of literature, contemporary literary and cultural theory]]></keywords_en><summary_hr><![CDATA[Projektni prijedlog fokusirat će se na pitanje koliko je suvremeni hrvatski roman društveno kritičan, kako izražava društvenu kritiku i koje društvene probleme najčešće kritizira. Uvažavajući činjenicu da je književni tekst istovremeno samodostatna estetska činjenica te poseban oblik društvene prakse, istraživanja u sklopu predloženog projekta kreću od hipoteze da suvremeni hrvatski roman na umjetnički relevantan način kritički propituje ne samo različite društvene probleme i tabue, kao što su društvena nejednakost i nepravda, politička korupcija, ideološke manipulacije i transgeneracijske traume, već i strukture i mehanizme koji stvaraju društvene položaje i vrijednosti. Druga osnovna hipoteza je da se društvenokritičke teme zastupljene u suvremenom hrvatskom romanu pojavljuju i u romanima autorica i autora iz susjednih kulturno i jezično bliskih postjugoslavenskih zemalja. Kako bi se provjerile te hipoteze, osnovni ciljevi ovog projektnog istraživanja bit će analiza i interpretacija različitih oblika i načina obrade društvenokritičkih tema u suvremenom hrvatskom i postjugoslavenskom romanu temeljem suvremenih književnih i kulturnih teorija koje razobličuju sustave moći i diskurzivne prakse koje utječu na produkciju i reprodukciju nejednakih odnosa moći između društvenih klasa, spolova, etničkih, rasnih i drugih skupina. Razlozi za planirana istraživanja leže u uvjerenju da je društvena kritičnost važan aspekt predmetnog korpusa i da zaslužuje sustavnija i ekstenzivnija istraživanja kakvih do danas nije bilo. U tom smislu predviđeni rezultati projektnog prijedloga (znanstveni radovi, konferencijska predavanja i bibliografsko-tematska baza podataka o obuhvaćenom korpusu) žele dati doprinos tom aspektu kroatističkih i slavističkih istraživanja.]]></summary_hr><summary_en><![CDATA[The project proposal will focus on the extent to which the contemporary Croatian novel is socially critical, how it expresses social criticism, and which social issues it most frequently critiques. Recognizing that a literary text is both a self-sufficient aesthetic entity and a specific form of social practice, the research within this proposed project starts from the hypothesis that the contemporary Croatian novel critically examines, in an artistically relevant manner, not only various social issues and taboos—such as social inequality and injustice, political corruption, ideological manipulation, and transgenerational trauma—but also the structures and mechanisms that create social positions and values. The second core hypothesis is that the socially critical themes present in contemporary Croatian novels also appear in the works of authors from neighbouring, culturally and linguistically related post-Yugoslav countries. To test these hypotheses, the primary objectives of this research project will be the analysis and interpretation of the different forms and methods of addressing socially critical themes in contemporary Croatian and post-Yugoslav novels based on contemporary literary and cultural theories that expose systems of power and discursive practices influencing the production and reproduction of unequal power relations between social classes, genders, ethnic, racial, and other groups. The motivation behind this planned research is the belief that social criticism is a significant aspect of the selected corpus and deserves more systematic and extensive study, which has been lacking so far. In this sense, the expected outcomes of the project proposal (scientific papers, conference lectures and a bibliographic-thematic database on the covered corpus) aim to contribute to this area of Croatian and Slavic literary studies.]]></summary_en></project><project>
<id>18352</id><title_hr><![CDATA[Latentna infekcija citomegalovirusom u središnjem živčanom sustavu]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4834</user_id><user_firstLast_name>Ilija Brizić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-6667</code><acronim><![CDATA[CMV-CNS]]></acronim><duration>01.02.2026 - 31.01.2032</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Medicine]]></institution_en><team_members_id>873088</team_members_id><team_members_names><![CDATA[ Doktorand: Iva Vladić ]]></team_members_names><keywords_hr><![CDATA[Citomegalovirus, prirođena infekcija, mikroglija, tkivno-rezidentni limfociti T, latencija, starenje ]]></keywords_hr><keywords_en><![CDATA[cytomegalovirus, congenital infection, microglia, tissue resident T cells, latency, aging]]></keywords_en><summary_hr><![CDATA[Mnogi virusi mogu uzrokovati trajne ili latentne infekcije i/ili upale u SŽS-u. Sve veći broj studija ukazuje da takve infekcije mogu uzrokovati različita patološka stanja i bolesti. Prirođena infekcija citomegalovirusom (CMV) glavni je uzrok transplacentarno prenosivih prirođenih infekcija i može uzrokovati širok raspon strukturnih i funkcionalnih oštećenja, te trajnih neuroloških posljedica. Naši preliminarni rezultati dobiveni upotrebom in vivo mišjeg modela prirođene infekcije CMV-om ukazuju da su neuroni mjesto latentne infekcije mišjim (M)CMV-om i mjesto reaktivacije, dok astrociti i mikroglija ne sadrže latentni virus. U latentno inficiranom središnjem živčanom sustavu (SŽS), limfociti T su doživotno zadržani u tkivu, te su potrebni za kontrolu MCMV-a. Nadalje, otkrili smo da je mikroglija trajno aktivirana u latentno inficiranom SŽS-u. Trenutno nije poznato kako limfociti T posreduju nadzor nad latentnom infekcijom u neuronima, te kako trajna aktivacija mikroglije doprinosi navedenim procesima. Osim toga, nije istražena sposobnost virusa koji reaktivira u neuronima da se širi na druge stanice. U ovom istraživanju ćemo odgovoriti na ta pitanja. Kako bi odredili može li se virus koji reaktivira u neuronima širiti na druge stanice, kultivirat ćemo latentno inficirane neurone sa stanicama prijemčljivim za MCMV i koristiti organotipski model kulture tkiva mozga. Kako bismo odredili ulogu aktivirane mikroglije u kontroli latentnog virusa, koristit ćemo različite pristupe za uklanjanje mikroglije, kao i inducibilne kondicionalne knock-out sojeve miševa za eliminaciju ključnih efektorskih molekula na mikrogliji. Na kraju, istražit ćemo strukturne i funkcionalne promjene mozga uzrokovane latentnom infekcijom CMV-om u mozgu tijekom starenja. Razumijevanje mehanizama oštećenja SŽS-a i otkrivanje mehanizama latentne infekcije ključno je za razvoj bolje terapije. Osim toga, ova će studija otvoriti nova istraživanja o latentnim virusnim infekcijama mozga.]]></summary_hr><summary_en><![CDATA[Many viruses can cause persistent or latent infections and/or inflammation in the CNS. Growing body of evidence suggests that such infections can cause wide array of pathologies and morbidities. Congenital cytomegalovirus (CMV) infection is a major cause of trans-placentally transmitted congenital infections and may cause a wide range of structural and functional disabilities and permanent neurological sequelae. Our preliminary data obtained using in vivo mouse model of congenital CMV infection shows that neurons are site of latent mouse (M)CMV infection and reactivation, while astrocytes and microglia do not carry latent virus. Latent MCMV infection in the CNS is associated with life-long retention of tissue-resident T cells which are required to control latent virus. Furthermore, we found that microglia is persistently activated in the latently infected CNS. It is not known which T cell mechanisms are required to control latent infection in neurons and how persistent activation of microglia contributes to these processes. In addition, the ability of virus reactivating in neurons to spread to other cells is not known. Here we will answer these questions. To assess if virus reactivating in neurons can spread to other cells we will cocultivate latently infected neurons with MCMV-susceptible cells, and use organotypic tissue culture model. To determine the role of activated microglia in control of latent virus, we will use microglia depletion approaches, as well as inducible conditional knockout mice to selectively eliminate key effector molecules of microglia. Finally, we will investigate brain structural and functional changes caused by latent CMV infection in the brain during aging. Understanding mechanisms of CNS damage and deciphering the mechanisms of latent infection, as well as associated immune response is crucial to develop better interventional therapy. In addition, this study will open new avenues of research of latent viral infections in brain.]]></summary_en></project><project>
<id>18354</id><title_hr><![CDATA[Poboljšanje fitokemijskog profila biljnih pripravaka prijenosom  metabolita iz ekstrakta donora i indukcijom abiotskog stresa]]></title_hr><title_en><![CDATA[ Improvement of phytochemical profile of herbal preparations by metabolite transfer  from donor extract and abiotic stress induction]]></title_en><user_id>3390</user_id><user_firstLast_name>Valerija Vujčić Bok</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2025-02</proposal_call><code>UIP-2025-02-2995</code><acronim><![CDATA[ImpPhytoHerb]]></acronim><duration>15.12.2026 - 14.12.2031</duration><status>U tijeku</status><financ_value>300.000,00 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Farmacija, Javno zdravstvo i zdravstvena zaštita, </scie_field_hr><scie_field_en>Pharmaceutical sciences, Public health and health services, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Farmaceutsko-biokemijski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Pharmacy and Biochemistry]]></institution_en><team_members_id>23329, 870485, 29396, 870349, 870423, </team_members_id><team_members_names><![CDATA[Ana Huđek Turković, Sanja Gagić, Tihana Marić, Domagoj Bosiljevac, Nika Celinić, ]]></team_members_names><keywords_hr><![CDATA[Cikla, špinat, biljni bioaktivni spojevi, biološki učinci, abiotski stres]]></keywords_hr><keywords_en><![CDATA[Beetroot, spinach, plant bioactive compounds, biological activity, abiotic stress]]></keywords_en><summary_hr><![CDATA[Cilj projekta je pripremiti biljni pripravak (ekstrakt i koncentrirani ekstrakt) cikle i špinata obogaćen biološki aktivnim tvarima. Poboljšanje bioaktivnosti i fitokemijskog profila postići će se prijenosom metabolita iz ekstrakta donora (vodeni ekstrakt kamilice – Matricariae flos i vodeni ekstrakt šipka Rosae pseudo fructus) tijekom uzgoja i uzgojem biljaka primjenom blagog abiotskog stresa (vodena otopina natrijevog klorida). Na taj način ekstrakt će biti obogaćen polifenolima i vitaminom C koji imaju blagotvoran učinak na zdravlje ljudi. Budući da sastav biološki aktivnih tvari ovisi o razvojnom stadiju biljke, obradit će se biljke u stadiju klijanca te u odraslom stadiju. Za postupak pripreme biljnih pripravaka (ekstrakt i koncentrirani ekstrakt) cikle i špinata koristit će se ultrazvučna i/ili rotaciona ekstrakcija i liofilizacija. Stabilnost spojeva (UV/VIS spekrofotometrija, FTIR te HPLC), te antioksidacijska i antidijabetička aktivnost (UV/VIS spektrofotometrija) biljnih pripravaka cikle i špinata bit će ispitana prije, tijekom i nakon in vitro probave. Allium cepa testom ispitat će se citotoksičnost i genotoksičnost biljnih pripravaka cikle i špinata.  Navedeni test će također biti korišten za ispitivanje fitoprotektivnog učinka. Na humanim staničnim linijama (tumorske i normalne) probavnog sustava te na stanicama ljudske krvi (eritrociti i limfociti) ispitat će se biološki učinak biljnih pripravaka cikle i špinata u uvjetima in vitro. ]]></summary_hr><summary_en><![CDATA[The aim of the project is to prepare a herbal preparation (extract and concentrated extract) of beetroot and spinach that will be enriched with biologically active substances. We plan to achieve the improvement of bioactivity and phytochemical profile by transferring metabolites from donor extracts (aqueous chamomile extract – Matricariae flos and aqueous rosehip extract Rosae pseudo fructus) during cultivation and by growing plants under mild abiotic stress (aqueous solution of sodium chloride). In this way, the extract will be enriched with polyphenols and vitamin C, which have a beneficial effect on human health. Since the composition of biologically active substances depends on the developmental stage of the plant, plants in the seedling stage and in the adult stage will be processed. For the process of preparation of herbal preparations (extract and concentrated extract) of beetroot and spinach, ultrasonic and/or rotary extraction and freeze-drying will be used. The stability of compounds (UV/VIS spectrophotometry, FTIR, and HPLC), as well as the antioxidant and antidiabetic activity (UV/VIS spectrophotometry) of beetroot and spinach plant preparations, will be investigated before, during, and after in vitro digestion. The Allium cepa test will examine the cytotoxicity and genotoxicity of beetroot and spinach plant preparations. This test will also be used to test the phytoprotective effect. The biological effect of herbal preparations of beetroot and spinach in vitro will be investigated on human cell lines (tumor and normal) of the digestive system and on human blood cells (erythrocytes and lymphocytes). ]]></summary_en></project><project>
<id>18358</id><title_hr><![CDATA[Gordijski čvor hrvatske demokracije: kako ga otpetljati?]]></title_hr><title_en><![CDATA[Gordian hub of Croatian democracy: how to untangle it?]]></title_en><user_id>13059</user_id><user_firstLast_name>Monika Pažur</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2025-02</proposal_call><code>UIP-2025-02-9500</code><acronim><![CDATA[DEMOhub]]></acronim><duration>08.12.2025 - 07.12.2030</duration><status>U tijeku</status><financ_value>142.480,00 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Pedagogija, Politologija, Sociologija, Interdisciplinarne društvene znanosti, </scie_field_hr><scie_field_en>Pedagogy, Political Science, Sociology, Interdisciplinary social sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Učiteljski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Teacher Education]]></institution_en><team_members_id>13048, 22714, 868234, 12807, 19356, </team_members_id><team_members_names><![CDATA[Dorijan Vahtar, Nadja Čekolj, Ivana Čavar, Marko Kovačić, Nikola Tomašegović, ]]></team_members_names><keywords_hr><![CDATA[demokratizacija obrazovanja, interdisciplinarnost, prepreke demokraciji, obrazovna politika, odgojno-obrazovne institucije]]></keywords_hr><keywords_en><![CDATA[democratization of education, interdisciplinarity, obstacles to democracy, educational policy, educational institutions]]></keywords_en><summary_hr><![CDATA[Projekt Gordijski čvor hrvatske demokracije: kako ga otpetljati? (DEMOhub) je znanstveno-istraživački projekt koji na temelju povezivanja politike, istraživanja i prakse nastoji doprinijeti većoj demokratizaciji lokalnih odgojno-obrazovnih politika kao i odgojno-obrazovnih institucija. Projekt počiva na ideji da demokracija podrazumijeva podjelu odgovornosti i disperziju moći između njenih građana, institucija i zajednica. Stoga je temeljni istraživački problem ovog projekta: kako je u visoko centraliziranoj državi moguće dostići standarde demokracije u odgoju i obrazovanju?. Ključna načela projekta koja se protežu kroz čitavo trajanje projekta i sve aktivnosti su: (1) interdisciplinarnost (povezivanje mladih istraživača iz različitih znanstvenih disciplina); (2) osnaživanje i umrežavanje mladih istraživača (edukacije); te (3) povezivanje istraživanja, politika i praksi odgoja i obrazovanja uz kontinuiranu razmjenu znanja (održavanja javnih događaja). Projekt ima tri specifična istraživačka cilja: (1) Doprinijeti osobnom i profesionalnom razvoju mladih istraživača kroz osnaživanje te kroz povezivanje s nacionalnom i međunarodnom mrežom znanstvenika i praktičara.; (2) Istražiti i bolje razumjeti koncept demokratizacije obrazovanja na četiri razine društva (nacionalna, lokalna, institucija, pojedinac) u realnom kontekstu hrvatskog društva koristeći se mixed-method pristupom.; (3) Izraditi evidance-based alate za samovrednovanje i unapređenje demokratskih politika i praksi na razini lokalne zajednice, institucije i za pojedinca, te ih učiniti dostupnima. Koristi će se sljedeće metode: metaanaliza sadržaja, kvantitativna metoda primjenom anketnom upitnika, kvalitativna metoda primjenom studija slučaja te kvalitativna metoda primjenom participativnog akcijskog istraživanja. Koristeći se različitim metodama, za istraživanje istog pojma, omogućuje se njegovo dublje razumijevanje te sagledavanje njegovih odrednica i elementa iz više različitih perspektiva.]]></summary_hr><summary_en><![CDATA[Project &#39;&#39;The Gordian Knot of Croatian Democracy: How to Untangle It?&#39;&#39; (DEMOhub) is a scientific research project that aims to contribute to the democratization of local educational policies and institutions by connecting politics, research, and practice.The project is based on the idea that democracy entails the division of responsibility and the dispersion of power among citizens, institutions, and communities. The central research question of this project is: How is it possible to achieve democratic standards in education in a highly centralized state? Key principles of the project: (1) Interdisciplinarity – bringing together young researchers from various scientific fields related to democracy in education; (2) Empowerment and networking of young researchers; (3) Connecting research, policy, and educational practices – ensuring continuous knowledge exchange through public events. Specific research objectives are: (1) Contributing to the personal and professional development of young researchers by empowering them and connecting them with national and international networks of scientists and practitioners.; (2) Investigating and better understanding the concept of democratization in education at four societal levels (national, local, institutional, and individual) within the real context of Croatian society using a mixed-method approach.; (3) Developing evidence-based tools for self-evaluation and improvement of democratic policies and practices at the local, institutional, and individual levels, making them accessible to the scientific and professional public. Research methodology that is going to be used is content meta-analysis, quantitative methods (surveys), qualitative methods (case study strategy), and participatory action research strategy.  By employing different methods to examine the same concept, the project enables a deeper understanding of democracy and its key components from multiple perspectives.]]></summary_en></project><project>
<id>18373</id><title_hr><![CDATA[Biokompatibilni Multimetalni Oksidni Nanokompoziti za Prevenciju Infekcija]]></title_hr><title_en><![CDATA[Biocompatible Multimetal Oxide Nanocomposites for Infection Control ]]></title_en><user_id>17652</user_id><user_firstLast_name>Nives Matijaković Mlinarić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2025-02</proposal_call><code>UIP-2025-02-6936</code><acronim><![CDATA[BIO-METONIC]]></acronim><duration>01.04.2026 - 31.03.2031</duration><status>U tijeku</status><financ_value>299.998,16 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Interdisciplinarne prirodne znanosti, Kemija, Biologija, </scie_field_hr><scie_field_en>Interdisciplinary natural sciences, Chemistry, Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>4103, 870346, 867796, 870390, </team_members_id><team_members_names><![CDATA[Marijan Marciuš, Ramona Jeitler, Janja Vidmar, Urška Šunta, ]]></team_members_names><keywords_hr><![CDATA[Nanočestice multimetalnih oksida, antimikrobne prevlake, elektroispredanje, epitaksijalni rast kalcijeva karbonata, prevencija infekcija]]></keywords_hr><keywords_en><![CDATA[Multi-metal oxide nanoparticles, Antimicrobial coatings, Electrospinning, Calcium carbonate epitaxial growth, Infection control]]></keywords_en><summary_hr><![CDATA[Infekcije u zdravstvenoj skrbi predstavljaju veliki izazov u suvremenoj medicini, posebno u njezi rana i infekcijama povezanim s implantatima. Medicinska pomagala u liječenju rana i ortopedski implantati idealne su površine za mikrobnu kolonizaciju i stvaranje biofilma, što dovodi do razvoja kroničnih infekcija, povećanog morbiditeta pacijenata i viših troškova zdravstvene skrbi. Nadalje, antimikrobna rezistencija predstavlja dodatan rizik te zahtijeva razvoj alternativnih antimikrobnih strategija.Ovaj projekt predlaže inovativan pristup razvijanju biokompatibilnih nanokompozita s nanočesticama multimetalnih oksida za kontrolu infekcija u liječenju rana i medicinskim implantatima. Nanočestice multimetalnih oksida koje sadrže kombinacije cinka, bakra, cerija i itrija će biti sintetizirane korištenjem kontroliranih solvotermalnih metoda te će biti stabilizirane organskim molekulama kako bi se poboljšala antimikrobna učinkovitost. Za razliku od premaza na bazi antibiotika, multimetalne nanočestice otvaraju mogućnost široke primjene zbog različitih mehanizama djelovanja pojedinačnih metala. Sintetizirane nanočestice će biti integrirane u biokompatibilne polimerne matrice i elektroispredene na površine tekstila i titana, stvarajući multifunkcionalne prevlake za obloge rana i ortopedske implantate. Nadalje, epitaksijalno nadrasli kalcijev karbonat (CaCO3) će se koristiti kako bi se poboljšala adhezija i rast koštanih stanica.Ovo interdisciplinarno istraživanje povezuje znanost o materijalima, nanotehnologiju, mikrobiologiju i biomedicinski inženjering, nudeći skalabilno rješenje za antimikrobne premaze s bioaktivnim i biokompatibilnim svojstvima. Kombinacijom multimetalnih oksidnih nanočestica, elektroispredanja polimera i bioaktivnih premaza s CaCO3, cilj ovog projekta je smanjiti infekcije povezane s implantatima i ranama te poboljšati ishode pacijenata, rješavajući ključne izazove u regenerativnoj medicini i prevenciji infekcija.]]></summary_hr><summary_en><![CDATA[Healthcare-associated infections pose a major challenge in modern medicine, particularly in wound care and implant-associated infections. Medical devices such as wound dressings and orthopaedic implants provide ideal surfaces for microbial colonisation and biofilm formation, leading to chronic infections, increased patient morbidity, and higher healthcare costs. Antimicrobial resistance further exacerbates these risks, necessitating the development of alternative antimicrobial strategies. This project proposes an innovative approach by developing biocompatible multi-metal oxide nanocomposites for infection control in medical implants and wound dressings. Novel multi-metal oxide nanoparticles (NPs) containing zinc, copper, cerium and yttrium combinations will be synthesised using controlled solvothermal methods and stabilised with organic molecules to enhance antimicrobial efficacy and dispersion. Unlike conventional antibiotic-based coatings, these nanoparticles act through multiple antimicrobial pathways. The synthesised multi-metal NPs will be integrated into biocompatible polymer matrices and electrospun onto textiles and titanium surfaces, creating multifunctional nanofibrous coatings for wound dressings and orthopaedic implants. To improve osteointegration, calcium carbonate (CaCO3) epitaxial growth will be employed to enhance bone cell attachment.This interdisciplinary research bridges materials science, nanotechnology, microbiology, and biomedical engineering, offering a scalable solution for antimicrobial coatings with enhanced bioactivity and biocompatibility. By combining multi-metal oxide NPs, polymer electrospinning, and bioactive CaCO3 coatings, this project aims to reduce implant-related infections, accelerate wound healing, and improve patient outcomes, addressing critical challenges in regenerative medicine and infection control.]]></summary_en></project><project>
<id>18374</id><title_hr><![CDATA[Algoritmi za učinkovitu analizu biomedicinskih vremenskih nizova]]></title_hr><title_en><![CDATA[]]></title_en><user_id>12928</user_id><user_firstLast_name>Alan Jović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-8257</code><acronim><![CDATA[ALFABEATS]]></acronim><duration>21.11.2025 - 20.11.2031</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>872976</team_members_id><team_members_names><![CDATA[ Doktorand: Jana Faber ]]></team_members_names><keywords_hr><![CDATA[biomedicinski vremenski nizovi, strojno učenje, algoritmi, obrada signala, objašnjiva umjetna inteligencija, web platforma, mobilna aplikacija]]></keywords_hr><keywords_en><![CDATA[biomedical time series, machine learning, signal processing, explainable artificial intelligence, web platform, mobile application]]></keywords_en><summary_hr><![CDATA[Biomedicinski vremenski nizovi (BVN) uključuju elektrokardiogram (EKG), elektroencefalogram (EEG) i mnoge druge. Automatizirana analiza BVN-ova pomoću metoda umjetne inteligencije omogućuje brži i učinkovitiji pristup ispitivanju velikih količina medicinskih podataka. Budući da je donošenje valjanih medicinskih odluka o pacijentima od najveće važnosti u zdravstvu, liječnici bi trebali imati pristup vrijednim programskim rješenjima koja će im pomoći u njihovim zadacima. Trenutačni algoritmi strojnog učenja (uključujući duboko učenje) pate od problema slabe objašnjivosti modela. Projekt ALFABEATS prvenstveno ima za cilj osmišljavanje novih algoritama strojnog učenja za analizu BVN-ova koji se mogu koristiti u medicinskoj praksi. Budući da važne medicinske odluke treba opravdati i objasniti pacijentu, nužno je da modeli strojnog učenja budu objašnjivi. Stoga će algoritmi osmišljeni unutar projekta težiti visokoj točnosti, objašnjivosti i računskoj učinkovitosti. Kako bi se ponudila usluga koja integrira razvijene algoritme, projekt će uključivati razvoj učinkovite i sigurne web platforme i mobilne aplikacije. Programska rješenja nudit će kompletan tok analize BVN-ova. Korišteni modeli ovisit će o potrebnom medicinskom scenariju. Scenariji obuhvaćeni rješenjima uključivat će najmanje pet klinički značajnih zadataka klasifikacije i otkrivanja događaja. I scenarije i programsko rješenje temeljito će vrednovati liječnici uključeni u projektnu skupinu. Anonimizirani skupovi medicinskih podataka na kojima će se algoritmi učiti i testirati bit će organizirani u lokalnoj banci podataka. Skupovi podataka bit će prikupljeni iz besplatno dostupnih internetskih izvora i od lokalnih medicinskih ustanova. Osim unaprjeđenja postojećih znanstvenih spoznaja u biomedicinskom inženjerstvu i računarskoj znanosti, širi utjecaj projekta bit će u razvijenoj programskoj usluzi koja se nudi registriranim liječnicima.]]></summary_hr><summary_en><![CDATA[Biomedical time series (BTS) include electrocardiogram (ECG), electroencephalogram (EEG), and many others. Automated BTS analysis using artificial intelligence methods allows us a faster and more efficient approach to examining large quantities of medical data. Since reaching valid medical decisions about patients is of paramount importance in healthcare, physicians should have access to valuable software solutions to help them with their tasks. Current machine learning (including deep learning) algorithms suffer from the issue of weak explainability of their models. The project ALFABEATS aims primarily at devising novel machine learning algorithms for BTS analysis that can be used in medical practice. Because important medical decisions need to be justified and explained to the patient, it is necessary for the machine learning models to be explainable. Therefore, the algorithms devised within the project will aim at high accuracy, explainability, and computational efficiency. To offer a service that integrates the developed algorithms, the project will include the development of an efficient and secure web platform and a mobile application. The software solutions will offer end-to-end BTS analysis. The used models will depend on the required medical scenario. The scenarios covered by the solutions will include at least five clinically significant classification and event detection tasks. Both the scenarios and the software solution will be thoroughly evaluated by the physicians included in the project group. The anonymized medical datasets on which the algorithms will be trained and tested will be organized in a local databank. The datasets will be acquired from freely available online resources and from local medical institutions. In addition to improving the existing scientific knowledge in biomedical engineering and computer science, the project&#39;s broader impact will be in the developed software service offered to registered physicians.]]></summary_en></project><project>
<id>18382</id><title_hr><![CDATA[Pronalaženje i genomska analiza ugroženih hrvatskih sorata vinove loze i divlje loze]]></title_hr><title_en><![CDATA[Prospection and genomic analysis of endangered Croatian grapevine cultivars and wild grapevine  ]]></title_en><user_id>1507</user_id><user_firstLast_name>Goran Zdunić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-5376</code><acronim><![CDATA[RemainGrape]]></acronim><duration>15.12.2025 - 14.12.2028</duration><status>U tijeku</status><financ_value>198.260,00 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, Interdisciplinarne biotehničke znanosti, </scie_field_hr><scie_field_en>Agriculture, Interdisciplinary biotechnical sciences, </scie_field_en><institution_hr><![CDATA[Institut za jadranske kulture i melioraciju krša]]></institution_hr><institution_en><![CDATA[Institute for Adriatic Crops and Karst Reclamation in Split]]></institution_en><team_members_id>21312, 865080, 3236, 2795, 26680, 870337, 3132, 2923, 865366, 870422, </team_members_id><team_members_names><![CDATA[Katarina Lukšić, Luka Marinov, Katarina Hančević, Ana Mucalo, Maja  Ozretić Zoković, Nikola Grabovac, Edi Maletić, Ivan Pejić, Gabriele Di Gaspero, Franco Roeckel, ]]></team_members_names><keywords_hr><![CDATA[vinova loza, germplazma, kolekcioniranje, očuvanje, karakterizacija, genomika     ]]></keywords_hr><keywords_en><![CDATA[grapevine, germplasm, collection, conservation, characterization, genomics ]]></keywords_en><summary_hr><![CDATA[Projekt RemainGrape istražuje ugrožene tradicionalne sorte vinove loze (Vitis vinifera L.) i populacije divlje loze (Vitis vinifera L. subsp. sylvestris Hegi Gmelin, dalje u tekstu sylvestris) u Hrvatskoj. Primjenjuje interdisciplinarni pristup u evaluaciji genetskih izvora vinove loze. Komplementarno primjenjuje fenotipske i genomske metode bazirane na novoj generaciji sekvenciranja DNA. Obuhvaća suradnju s lokalnim poznavateljima bioraznolikosti loze i potencijalnih područja s ciljem identifikacije preostalih skrivenih sorata i populacija sylvestrisa na terenu. Uzorkovanje će se provoditi u preostalim starim vinogradima na povijesnim vinogradarskim lokalitetima naročito jadranskog područja i manjeg dijela kontinentalnog područja Hrvatske. Fenotipske karakteristike prikupljenih uzoraka analizirati će se standardnim deskriptorima za opis loze i metodama visoke propusnosti, dok će se genetska raznolikost procijeniti mikrosatelitnim markerima i ciljanim sustavom sekvenciranja temeljenog na tehnologiji single primer enrichment technology (SPET) panela koji se sastoji od 50.000 proba genskog prostora Vitis vinifera L. Dobiveni podatci integrirati će se s povijesnom ampelografskom literaturom i međunarodnom bazom podataka za Vitis vrste (Vitis International Variety Catalogue - www.vivc.de). Projekt RemainGrape pridonijet će očuvanju globalne genetske raznolikosti vinove loze i populacija sylvestrisa, doprinoseći zaštiti preostalih ugroženih sorata koje nedostaju u mozaiku bioraznolikosti vinove loze. Također, omogućit će bolje razumijevanje genetske strukture hrvatskih sorti i sylvestrisa te pružiti podatke o prisutnosti rezistentnih gena koji bi mogli biti značajni za prilagodbu klimatskim promjenama i održivo vinogradarstvo. ]]></summary_hr><summary_en><![CDATA[The RemainGrape project investigates endangered traditional grapevine cultivars (Vitis vinifera L.) and wild grapevine populations (Vitis vinifera L. subsp. sylvestris Hegi Gmelin, hereinafter referred to as sylvestris) in Croatia. It applies an interdisciplinary approach to evaluating grapevine genetic resources, combining phenotypic and genomic methods based on next-generation DNA sequencing. The project involves collaboration with local biodiversity experts and field specialists to identify remaining hidden cultivars and sylvestris populations in the field. Sampling will be conducted in the remaining old vineyards located at historical viticultural sites, particularly in the Adriatic region and a smaller part of continental Croatia. The phenotypic characteristics of collected samples will be analyzed using standard grapevine descriptors and high-throughput methods, while genetic diversity will be assessed using microsatellite markers and a targeted sequencing system based on the Single Primer Enrichment Technology (SPET) panel, which includes 50,000 probes covering gene space of the Vitis vinifera L. genome. The obtained data will be integrated with historical ampelographic literature and the international Vitis species database (Vitis International Variety Catalogue – www.vivc.de). The RemainGrape project will contribute to the conservation of global grapevine genetic diversity and sylvestris populations, helping to protect endangered cultivars that are missing from the grapevine biodiversity mosaic. Additionally, it will enhance understanding of the genetic structure of Croatian grapevine cultivars and sylvestris, providing insights into the presence of resilience genes that may be beneficial for climate change adaptation and sustainable viticulture.]]></summary_en></project><project>
<id>18384</id><title_hr><![CDATA[Istraživanje teritorijalnih ostataka i infrastrukturnih sustava Carstva u Panoniji: Mapiranje rimske infrastrukture]]></title_hr><title_en><![CDATA[Tracing the Empire&#39;s Territorial Remnants and Infrastructural Systems in Pannonia: Roman Infrastructure Mapping]]></title_en><user_id>2786</user_id><user_firstLast_name>Ivana Ožanić Roguljić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-1060</code><acronim><![CDATA[RIM]]></acronim><duration>05.12.2025 - 04.12.2028</duration><status>U tijeku</status><financ_value>199.100,00 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Arheologija, </scie_field_hr><scie_field_en>Archeology, </scie_field_en><institution_hr><![CDATA[Institut za arheologiju]]></institution_hr><institution_en><![CDATA[Institute of Archaeology in Zagreb]]></institution_en><team_members_id>855859, 865831, 22553, 22573, 11219, 865832, 868319, 865833, 865984, </team_members_id><team_members_names><![CDATA[Jere Drpić, Dominik Hagmann, Anita Rapan Papeša, Angelina Raickovic Savic, Kristina Jelinčić Vučković, Maja Janežič, Kaja Stemberger Flegar, Nikolina Ostović, Hrvoje Vulić, ]]></team_members_names><keywords_hr><![CDATA[rimski ruralni krajolik, rimska Panonija, infrastrukturni sustavi,  daljinsko istraživanje, materijalna kultura, arheioška istraživanja]]></keywords_hr><keywords_en><![CDATA[Roman rural landscape, Roman rural settlements, Roman  Pannonia, Infrastructure systems, Remote sensing, Material  culture, Archaeological research]]></keywords_en><summary_hr><![CDATA[ Projekt RIM je interdisciplinarna inicijativa koja istražuje i rekonstruira provincijski rimski ruralni krajolik istočne Hrvatske  (današnja Slavonija/Panonija u rimskom razdoblju). Korištenjem naprednih tehnologija poput daljinskog istraživanja, GIS-a i  zračnih snimaka, projekt nastoji stvoriti detaljno razumijevanje  prostorne organizacije i nfrastrukturnih sustava rimskih ruralnih  naselja. Ključni aspekt projekta uključuje georeferenciranje  postojećih podataka o rimskim ruralnim lokalitetima u istočnoj  Slavoniji. Ovaj napor ima za cilj razvoj sveobuhvatne i prostorno  točne baze podataka koja mapira lokacije i raspodjelu rimskih  naselja, pružajući nova saznanja o njihovoj prostornoj  organizaciji i međusobnoj povezanosti u regiji. Projekt također  uključuje pažljivo odabrani case study s fokusom na rimska ruralna naselja u blizini Apševaca. Ovaj case study pruža vrijedne uvide u specifične karakteristike rimskih ruralnih naselja  u istočnoj Slavoniji i njihovu ulogu unutar šireg rimskog krajolika  kroz detaljnu analizu njihovih arhitektonskih obilježja,  prostornog rasporeda i materijalne kulture. Projekt stavlja  poseban naglasak na analizu sitnog materijala i keramike pronađenih na tim naseljima i tijekom terenskih istraživanja.  Istraživanjem ovih artefakata, cilj je otkriti aspekte  svakodnevnog života, trgovačkih mreža i društvene dinamike koje su oblikovale rimske ruralne zajednice. Keramika, osobito,  nudi ključne dokaze za razumijevanje gospodarskih i kulturnih  obrazaca regije. Kombiniranjem inovativnih istraživačkih metoda s ciljanom terenskom studijom, projekt RIM pruža sveobuhvatan  pogled na utjecaj Rimskog Carstva u istočnoj Slavoniji,  obogaćujući naše razumijevanje njezinih ruralnih krajolika i  infrastrukture. ]]></summary_hr><summary_en><![CDATA[The RIM project is an interdisciplinary initiative to explore and reconstruct eastern Croatia&#39;s provincial Roman rural landscape  (today Slavonia/ Panonnia in the Roman period). By employing advanced technologies such as remote sensing, GIS, and aerial photography, the project seeks to create a detailed understanding of the spatial organisation and infrastructure systems of Roman rural settlements. A key aspect of the project involves georeferencing existing data on Roman rural sites in Eastern Slavonia. This effort aims to develop a comprehensive, spatially accurate database that maps the locations and distribution of Roman settlements, providing new insights into their spatial organisation and interconnections across the region. The project also incorporates a carefully selected case study focusing on two Roman rural settlements near Apševci.  This case study provides valuable insights into the specific characteristics of Roman rural settlements in Eastern Slavonia and their role within the broader Roman landscape through detailed analysis of their architectural features, layout, and material culture. The project emphasises the analysis of small materials and pottery recovered from these settlements and field surveys. By examining these artefacts, the research aims to uncover aspects of daily life, trade networks, and social dynamics that shaped Roman rural communities. Pottery, in particular, offers crucial evidence for understanding the region&#39;s economic and cultural patterns. By combining innovative research methods with targeted field studies, the RIM project offers a comprehensive perspective on the Roman Empire&#39;s influence in Eastern Slavonia, enriching our understanding of its rural landscapes and infrastructure.]]></summary_en></project><project>
<id>18403</id><title_hr><![CDATA[Suradna čovjek-robot manipulacija koja razmatra geometriju i nesigurnost]]></title_hr><title_en><![CDATA[]]></title_en><user_id>865708</user_id><user_firstLast_name>Luka Petrović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-5671</code><acronim><![CDATA[HORACE]]></acronim><duration>01.12.2025 - 30.11.2031</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>872936</team_members_id><team_members_names><![CDATA[ Doktorand: Naomi Kombol ]]></team_members_names><keywords_hr><![CDATA[Suradnja čovjek-robot, Riemannove mnogostrukosti, geometrijska algebra, algebra udaljenosti, učenje vještina, humanoidni robot]]></keywords_hr><keywords_en><![CDATA[Human-robot collaboration, Riemmanian manifolds, Geometric algebra, Distance algebra, Skill learning, Humanoid robot]]></keywords_en><summary_hr><![CDATA[Čovječanstvo je kroz povijest razvijalo ingeniozne ideje kako bi proizvelo strojeve koji mogu zamijeniti ljude u ponavljajućim, opasnim i napornim zadacima kako vrijedna ljudska inteligencija ne bi ostala zarobljena u zadacima koje još nismo naučili automatizirati. Nedavni napredak u antropomorfnim robotima i industrijskim manipulatorima s dvije ruke doveo je do povećanog interesa za probleme koji se odnose na dvoručnu manipulaciju i suradnju čovjeka i robota (SČR). Međutim, SČR je suptilan i izazovan iz više aspekata, u rasponu od besprijekorne, sigurne i prirodne fizičke suradnje, gdje se povezani znanstveni problemi kreću od upravljanja niske razine do planiranja i izvršenja zadataka na visokoj razini, pa sve do psiholoških aspekata rada s ljudima. U projektu HORACE razmatramo koordiniranu dvoručnu manipulaciju, konkretno, kada su ruke u fizičkoj interakciji jedna s drugom i čovjekom dok rješavaju isti zadatak. Takvi problemi se mogu u osnovi promatrati kao problemi geometrije i u posljednje vrijeme dosta se je istraživačkog truda posvetilo reprezentaciji i korištenju svojstava geometrije za rješavanje različitih problem učinkovitije. U projektu HORACE istražit ćemo upotrebu različitih geometrijskih deskriptora, zajedno s njihovim probabilističkim proširenjem, kako bismo modelirali varijacije zadatka i nesigurnosti unutar geometrijske karakterizacije zadatka koji treba postići. Predloženim pristupom možemo iskoristiti snagu ovih matematičkih alata te tako poboljšati i otvoriti nova područja za SČR manipulaciju u stvarnom svijetu prožetim neizvjesnošću. Na kraju, HORACE će dovesti do novih metodoloških razvoja koji će proizvesti učinkovitiju suradnju čovjeka i robota te bolje razumijevanje te složene geometrijske strukture.]]></summary_hr><summary_en><![CDATA[Humankind has throughout the history worked in ingenious ways to produce machines that can replace humans in repetitive, dangerous, and arduous tasks so that valuable human intelligence does not lay trapped in tasks we have not yet learned to automate. Recent advances in both anthropomorphic robots and dual-arm industrial manipulators have led to an increased interest in the specific problems pertaining to bimanual manipulation and human-robot collaboration (HRC). However, HRC is subtle and challenging from multiple aspects, ranging from seamless, safe and natural physical collaboration, where the related scientific problems range from low-level control to high level task planning and execution, to psychological aspects of working with humans. In HORACE, we focus on the coordinated bimanual manipulation, specifically on the problems when arms are physically interacting with one another and with a human while solving the same task. Such problems can be viewed fundamentally as problems of geometry, and a lot of recent research effort is dedicated to representing and utilizing these geometric properties for solving a wider variety of problems more efficiently. In HORACE, we will explore the use of varied geometric descriptors together with their probabilistic extension, since working with humans inherently includes stochasticity, in order to model task variations and uncertainty within a geometric characterization of the tasks to achieve. With the proposed approach we can harness the power of these mathematical representations, thus enhance and open new venues for HRC manipulation in real world scenarios riddled with uncertainty.  In the end, HORACE will lead to novel methodological developments yielding more efficient human-robot collaboration and better understanding of the complex geometrical structure of human-robot collaboration.]]></summary_en></project><project>
<id>18408</id><title_hr><![CDATA[Izloženost, biološki učinci i sudbina mikroplastike u akvatičkih organizama pod različitim antropogenim utjecajima]]></title_hr><title_en><![CDATA[]]></title_en><user_id>12330</user_id><user_firstLast_name>Vlatka Filipović Marijić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-2551</code><acronim><![CDATA[PlastOrgAnoTox]]></acronim><duration>22.01.2026 - 21.01.2031</duration><status>U tijeku</status><financ_value>60,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>873061</team_members_id><team_members_names><![CDATA[ Doktorand: Davor Merkas ]]></team_members_names><keywords_hr><![CDATA[Mikroplastika, zagađenje, akvatički organizmi, izloženost, biomarkeri, opasnost, procjena rizika]]></keywords_hr><keywords_en><![CDATA[Microplastics, pollution, aquatic organisms, exposure, biomarkers, hazard, risk assessment]]></keywords_en><summary_hr><![CDATA[Prisustvo mikroplastike (MP) u okolišu predstavlja globalni problem današnjice. Većina istraživanja usmjerena je na morske ekosustave, iako su i slatkovodni opterećeni unosom MP-a te predloženi projekt obuhvaća riječni sustav (Krka) i Jadransko more kod ušća Krke s ciljem procjene prisustva MP-a u vodi, sedimentu i akvatičkim organizmima (ribe i školjkaši) iz okoliša i uzgoja. Projektni ciljevi uključuju a) određivanje učinaka i bioloških promjena u divljih i eksperimentalnih organizama u ovisnosti o izloženosti MP-u i b) procjenu okolišnog rizika i izbor novih biomarkera izloženosti MP-u. Biološki učinci MP-a na organizme će se istraživati u područjima pod antropogenim utjecajima (otpadne vode, poljoprivreda, turizam, nautičke marine), kontrolnoj postaji (izvor rijeke Krke), te na uzgajalištima potočnih pastrva, orada i dagnji. Probavilo, škrge i mišići riba te probavna žlijezda, škrge i plašt dagnji predstavljat će ciljne organe. Uz divlje populacije, koje su pod utjecajem smjese zagađivala, eksperimentalni organizmi će se izložiti određenim vrstama, veličinama, koncentracijama i oblicima MP-a, individualno te u kombinaciji s različitim vrstama polimera i zagađivala (metali). Biološke promjene kao posljedica izlaganja MP-u (ribe i dagnje iz okoliša, dagnje iz pokusa) će obuhvaćati fiziološke promjene, genotoksičnost, neurotoksičnost i multibiomarkerski pristup. Sudbina MP-a u mekim tkivima te mogući mehanizam ugradnje u ljušturu analizirat će se u izloženim dagnjama, kao dobro poznatim sedentarnim organizmima. Akutna toksičnost MP-a procijenit će se u vodenbuha, predstavnika primarnih potrošača u slatkovodnim ekosustavima. Crijevni nametnici riba, kukaši, poslužit će kao novi model za procjenu mehanizma potencijalnog izlaganja i unosa MP-a u nametnike. Sveobuhvatni rezultati o utjecaju MP-a u realnim uvjetima okoliša, akvakulturi, pokusnim izlaganjima će dati inovativne podatke koji će omogućiti procjenu okolišnog rizika i izbor novih biomarkera izloženosti MP-u.]]></summary_hr><summary_en><![CDATA[The presence of microplastics (MP) in environment is considered a global problem. Most research is focused on marine ecosystems, although freshwaters are also burdened with MP, so the proposed project covers riverine system (Krka) and the Adriatic Sea at the mouth of the Krka River to assess MP occurrence in water, sediment and aquatic organisms (fish and mussels), considering wild and farmed populations. The project objectives are: (a) to assess relation of MP occurrence with effects and biological changes in wild and exposed aquatic organisms and (b) to identify environmental risks and discover novel biomarkers of MP exposure. Biological effects of MP on organisms will be studied in anthropogenically affected areas (wastewater, agriculture, tourism, nautical marinas), control site (river spring) and farming sites of brown trout, gilthead seabream and mussels. Intestine, gills and muscle in fish and digestive gland, gills and mantle in mussels represent target organs. In addition to wild populations, impacted by mixture of contaminants, organisms will be exposed to certain types, sizes, concentrations and shapes of MP and their combination with other polymer types and pollutants (metals). Measured biological changes upon exposure to MP (fish and mussels from environment, mussels from experiments) will include physiological changes, genotoxicity, neurotoxicity and multibiomarker approach. The fate of MP in soft tissues and possible mechanism of incorporation into the shell will be analysed in exposed mussels, a well-known sentinel organism. Acute toxicity of MP will be assessed in daphnids, representatives of primary consumers in freshwaters. Fish intestinal parasites, acanthocephalans, will serve as a new model for assessing mechanism of possible co-exposure and MP uptake in parasites. Comprehensive results on MP impact in environment, aquaculture, experimental exposures, will provide input data for environmental risk assessment and novel biomarkers of MP exposure.]]></summary_en></project><project>
<id>18409</id><title_hr><![CDATA[Stvaranje Materije Tijekom Kozmičkog Zagrijavanja]]></title_hr><title_en><![CDATA[Matter Production During Cosmic Reheating]]></title_en><user_id>870753</user_id><user_firstLast_name>Juraj Klaric</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2025-02</proposal_call><code>UIP-2025-02-3909</code><acronim><![CDATA[MaCoRe]]></acronim><duration>01.04.2026 - 31.03.2031</duration><status>U tijeku</status><financ_value>296.513,60 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>13010, 870969, </team_members_id><team_members_names><![CDATA[Filip Erhardt, Marko Sossich, ]]></team_members_names><keywords_hr><![CDATA[fizika elementarnih čestica, rani svemir, tamna tvar, kozmička inflacija, fizika van ekvilibrija, bariogeneza, leptogeneza]]></keywords_hr><keywords_en><![CDATA[elementary particle physics, early universe, dark matter, cosmic inflation, non-equilibrium physics, baryogenesis, leptogenesis]]></keywords_en><summary_hr><![CDATA[Ovaj projekt usmjeren je na proučavanje procesa kozmičkog zagrijavanja (eng. reheating) nakon inflacije. Nakon brzog inflacijskog razdoblja u našem trenutnom kozmološkom modelu, Svemir je ostao hladan, prazan i bez čestica, s cjelokupnom energijom pohranjenom u inflaton polju. Zagrijavanje je ključna faza tijekom koje se ta energija prenosi na čestice Standardnog modela, što dovodi do vrućeg, gustog Svemira i utire put nukleosintezi Velikog praska. Postojeća istraživanja ponovnog zagrijavanja oslanjaju se ili na klasične simulacije na rešetci, koje imaju poteškoće s proizvodnjom fermiona i potpunom termalizacijom, ili na izračune koji uključuju kvantne efekte, ali su ograničeni na perturbativne scenarije. Cilj ovog projekta je razviti jedinstveni pristup koji integrira neperturbativne aspekte simulacija na rešetci s nužnim kvantnim efektima kako bi se precizno opisala termalizacija i s njom povezana proizvodnja tamne i vidljive materije.]]></summary_hr><summary_en><![CDATA[This project focuses on studying the process of cosmic reheating following inflation. After the rapid inflationary period in our current cosmological model, the Universe was left cold, empty, and devoid of particles, with all energy stored in the inflaton field. Reheating is the crucial phase where this energy is transferred to Standard Model particles, leading to a hot, dense Universe and paving the way for Big Bang Nucleosynthesis. Existing studies of reheating either rely on classical lattice simulations, which struggle with fermion production and full thermalization, or on computations that include quantum effects, but are limited to perturbative scenarios. This project aims to develop a unified approach that integrates the non-perturbative aspects of lattice simulations with the necessary quantum effects to accurately describe thermalization and the associated production of dark and visible matter.]]></summary_en></project><project>
<id>18410</id><title_hr><![CDATA[Više-stupanjski simulacijski okvir za evaluaciju utjecaja autonomne mobilnosti na sigurnost i protočnost prometa na autocestama]]></title_hr><title_en><![CDATA[Multi-stage Simulation Framework for evaluating the impact of Autonomous Mobility on Motorways throughput and safety]]></title_en><user_id>12323</user_id><user_firstLast_name>Martin Gregurić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2025-02</proposal_call><code>UIP-2025-02-1083</code><acronim><![CDATA[VAMONA]]></acronim><duration>15.12.2025 - 14.12.2030</duration><status>U tijeku</status><financ_value>169.002,41 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Tehnologija prometa i transport, Računarstvo, </scie_field_hr><scie_field_en>Transport technology, Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet prometnih znanosti]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Transport and Traffic Sciences]]></institution_en><team_members_id>25509, 29087, 869911, </team_members_id><team_members_names><![CDATA[Krešimir Kušić, Filip Vrbanić, Lucija Bukvić, ]]></team_members_names><keywords_hr><![CDATA[Autonomna vozila, generativna umjetna inteligencija, mikorskopski prometni simulatori, digitalni blizanac, upravljanje prometom na autocestama]]></keywords_hr><keywords_en><![CDATA[Autonomous vehicles, generative artificial intelligence, microscopic traffic simulators, digital twin, motorway traffic control]]></keywords_en><summary_hr><![CDATA[Glavni cilj ovog projekta je korištenje različitih okvira za simulaciju prometa organiziranih u uzastopne faze u svrhu sustavne procjene utjecaja Autonomnih Vozila (AV) na propusnost i sigurnost autoceste. Višefazni proces evaluacije provest će se korištenjem različitih udjela AV-ova u simuliranim prometnim tokovima. Koristit će se dvije skupine simulacijskih okvira. Prvi od njih temelji se na izoliranim sintetičkim modelima autocesta umjerenih sa prometnom potražnjom iz stvarnog svijeta, dok se drugi temelji na Digitalnom Blizancu autoceste umjerene prema parametrima iz stvarnog svijeta. Nadalje, sekundarni cilj je korištenje više-faznog simulacijskog okvira za učenje jednog aspekta vožnje AV-ova sa strateškim ciljem poboljšanja ukupne propusnosti autoceste. Isti će služiti kao testni primjer za predloženi više-stupanjski simulacijski pristup evaluacije njihovog utjecaja na sigurnost i protočnost autoceste. Stoga će se dodatni prometni scenariji stvoriti pomoću generativnih AI modela za sintetičke modele autocesta kako bi se povećala raznolikost simulacijskih scenarija. Ovaj pristup potencijalno će poboljšati konvergenciju učenja i istovremeno uvesti sveobuhvatniju procjenu utjecaja AV-ova u ranim fazama predloženog ekosustava simulacijske evaluacije. Naposljetku, Digitalni Blizanac će se koristiti za dugoročnu simulacijsku evaluaciju naučenih AV-ova koristeći podatke o prometu u stvarnom vremenu na sustavima autocesta iz stvarnog svijeta. Digitalni Blizanac se može koristiti za dodatno učenje AV-ova ako prva evaluacija daje loše rezultate u pogledu ukupne propusnosti i sigurnosti autoceste.]]></summary_hr><summary_en><![CDATA[The main goal of this project is to use various traffic simulation frameworks arranged in consecutive stages for systematic evaluation of Autonomous Vehicles (AVs) impact on the motorway&#39;s throughput and safety. The multi-stage evaluation process will be conducted by using different penetration rates of AVs in simulated traffic flows. Two groups of simulation frameworks will be used. The first of them is based on isolated synthetic motorway models and real-world traffic demand while the second is based on a Digital-Twin (DT) of a real-world motorway system. Furthermore, a secondary goal is to use proposed stages of simulation frameworks to train one driving aspect of AVs with a strategic goal of improving overall motorway throughput. It will serve as a use case for proposed multi-stage evaluation ecosystems based on traffic simulations.  Thus, additional traffic scenarios will be created by generative AI models for synthetic motorway models to boost the variety of simulated traffic scenarios. This approach will potentially improve the training convergence and simultaneously introduce a more comprehensive evaluation of AVs at the early stages of the proposed multi-simulation evaluation ecosystem. Finally, the DT will be used for long-term simulation evaluation of trained AVs using real-time traffic data on real-world motorway systems. The DT can be used for retraining the AVs if the first evaluation provides poor results regarding the overall throughput and safety.]]></summary_en></project><project>
<id>18412</id><title_hr><![CDATA[Moralni napredak: individualni i kolektivni]]></title_hr><title_en><![CDATA[]]></title_en><user_id>2690</user_id><user_firstLast_name>Tvrtko Jolić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-5707</code><acronim><![CDATA[MoPIC]]></acronim><duration>01.12.2025 - 30.11.2030</duration><status>U tijeku</status><financ_value>60,00 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filozofija, </scie_field_hr><scie_field_en>Philosophy, </scie_field_en><institution_hr><![CDATA[Institut za filozofiju]]></institution_hr><institution_en><![CDATA[Institute for Philosophy in Zagreb]]></institution_en><team_members_id>872998</team_members_id><team_members_names><![CDATA[ Doktorand: Monika Zeba ]]></team_members_names><keywords_hr><![CDATA[Moralni napredak, emocije, metaetika, moralna odgovornost, moralno biopoboljšanje, bihevioralni utjecaji, pojedinci, kolektivi.]]></keywords_hr><keywords_en><![CDATA[Moral progress, emotions, metaethics, moral responsibility, moral bioenhancement, nudges, individuals, collectives.]]></keywords_en><summary_hr><![CDATA[Polazeći od stajališta da je moral složeni sustav koji počiva na spoznajnim, afektivnim i bihevioralnihm elementima, naše istraživanje cilja istražiti i razmotriti ulogu koju ti elementi imaju u procesima moralnoga napredovanja ili nazadovanja. To ćemo učiniti ispitujući oblike i karakteristike individualnog i kolektivnog moralnog razvoja kako bismo ustanovili sličnosti i razlike između ta dva oblika moralnog razvoja kao i njihovu povezanost i međusobni utjecaj. Osnovna hipoteza istraživanja glasi da su individualni i kolektivni moralni napredak dvije odvojene vrste moralnog napretka, ali da su ovisni jedan o drugomu i da se, u povoljnim okolnostima, međusobno podupiru. Istraživanje namjeravamo provesti u četiri različita ali međusobno povezana segmenta. U prvome segmentu istražit će se moralni napredak pojedinaca pri čemu će se poseban naglasak staviti na ulogu emocija u moralnom napretku. Drugi segment posvećen je razmatranju kolektivnog moralnog napretka. Ovaj dio istraživanja ima dvije zadaće: 1.) utvrditi za koje vrste kolektiva možemo tvrditi da moralno napreduju ili nazaduju i 2.) utvrditi ulogu moralne refleksije u moralnom napretku. Treći segment istraživanja bavi se međusobnim odnosom individualnog i kolektivnog moralnog napretka i razmatranjem bihevioralnog aspekta moralnog napretka. Na kraju, zadaća četvrtog segmenta istraživanja jest da istraživačke uvide o individualnom i kolektivnom moralnom napretku smjesti u odgovarajući metaetički i evolucijski okvir.]]></summary_hr><summary_en><![CDATA[Starting from the assumption that morality is a complex system that rests on cognitive, affective, and behavioural elements, our research aims to explore and consider the role of these elements in moral progress and regress. We go about this task by assessing the forms and properties of individual and collective moral development in order to determine the similarities and differences between these two kinds of moral development, as well as their relatedness and mutual influence. The main research hypothesis states that individual and collective moral progress are two distinct kinds of moral progress, yet they are mutually dependent and reinforce one another in favourable circumstances. The research project is to be carried out in four distinct, yet interwoven tracks. As part of the first track, we explore the moral progress of individuals with a particular emphasis on the role of emotions in moral progress. The second track considers collective moral progress, setting itself with two tasks: 1) to determine the kinds of collectives that could be considered agents of moral progress or regress; 2) to determine the role of moral reflection in moral progress. The third research track deals with the correlation between individual and collective moral progress, as well as with exploring the behavioural aspect of moral progress. Finally, the fourth research track aims to incorporate the resulting insights about individual and collective moral progress into a metaethical and evolutionary frame. Each research track is elaborated in further detail below.]]></summary_en></project><project>
<id>18413</id><title_hr><![CDATA[Utjecaj ponavljajućih sekvenci na molekularnu evoluciju i arhitekturu genoma školjkaša]]></title_hr><title_en><![CDATA[The impact of repetitive sequences on the molecular evolution and architecture of bivalve genomes]]></title_en><user_id>2778</user_id><user_firstLast_name>Eva Šatović Vukšić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-4073</code><acronim><![CDATA[GENREP]]></acronim><duration>08.12.2025 - 07.12.2028</duration><status>U tijeku</status><financ_value>199.660,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>506, 868177, 26098, 26112, 20981, </team_members_id><team_members_names><![CDATA[Miroslav Plohl, Patrik Majcen, Juan J Pasantes, Daniel  García Souto, Andrea Luchetti, ]]></team_members_names><keywords_hr><![CDATA[satellitne DNA, transponirajući elementi, Helitron, satelitom, mobilom, usklađena evolucija, komparativna genomika, heterokromatin, molekul. biologija]]></keywords_hr><keywords_en><![CDATA[satellite DNA, transposable elements, Helitron, satellitome, mobilome, concerted evolution, comparative genomics, heterochromatin, molecular biology]]></keywords_en><summary_hr><![CDATA[Ponavljajuće sekvence DNA su najzastupljenije komponente svakog eukariotskog genoma. One se dijele na dvije glavne skupine: satelitne DNA (satDNA), koje se sastoje od nizova uzastopno ponovljenih jedinica te transponirajuće elemente (TE), raspršene diljem genoma. SatDNA i TE ključni su graditelji arhitekture genoma i pokretači njegove evolucije, kroz procese koji reorganiziraju ponavljajuće sekvence DNA i mijenjaju njihov broj kopija. &#39;&#39;Mobilom&#39;&#39; (cjelokupni skup TE u genomu) snažno doprinosi plastičnosti eukariotskog genoma, kroz eksplozije TE aktivnosti. Evolucija satDNA prati nekoliko uvriježenih principa poput: organizacije u duge nizove smještene u heterokromatinu, &#39;&#39;model biblioteke&#39;&#39; i koncept &#39;&#39;usklađene evolucije&#39;&#39;. Istraživački interes koji obuhvaća sve aspekte biologije školjkaša je brzo-rastući i usmjerava se prema sveobuhvatnim &#39;&#39;omics&#39;&#39; analizama (uključujući satelitomiku i repeatomiku). Naše analize repetitivnih sekvenci kamenica otkrile su nove obrasce i iznimke od kanonskih koncepata, pružajući vrijedne doprinose znanstvenom području biologije repetitivnih DNA. Također, satDNA ovih organizama su pokazale snažnu povezanost s TE. Koristeći različite eksperimentalne i bioinformatičke pristupe, ovaj projekt namjerava istražiti  ulogu TE u organizaciji, širenju i evoluciji satDNA nekoliko vrsta kamenica. Bit će ispitan stupanj &#39;&#39;usklađene evolucije&#39;&#39; i uspoređen za samostalne i TE-inkorporirane nizove satDNA, unutar i između vrsta. Bit će istražena razlika u količini i sadržaju heterokromatina te identificiran i uspoređen aktivni dio mobiloma kamenica. Dobiveni rezultati dat će vrijedan doprinos razumijevanju repetitivnih krajolika genoma te njihovog utjecaja na kromosomsku arhitekturu. Istovremeno, komparativna repeatomika pružit će uvid u evolucijske procese i odnose među repetitivnim sekvencama srodnih vrsta.]]></summary_hr><summary_en><![CDATA[The ubiquitous and at the same time the least understood components of every eukaryotic genome are repetitive DNA sequences.  They are divided into two groups: satellite DNAs (satDNAs), composed of sequences repeated in tandem, and transposable elements (TEs), interspersed throughout the genome. Due to their ability to reorganize and change their copy number, repetitive DNAs are crucial builders of genome architecture and drivers of genome evolution.  The “mobilome” (the entire set of TEs in a genome) contributes strongly to eukaryote genome plasticity through bursts of activity. The evolution of satDNAs is governed by several well-established principles: organization into heterochromatin-associated long arrays, the “library model”, and “concerted evolution”. The research interest encompassing all aspects of bivalve biology is fast-growing, especially genome-wide “omics” analyses (including satellitomics and repeatomics). In our previous research, repetitive sequences of oysters have shown new patterns and exceptions from the canonical concepts, providing valuable contributions to the repetitive DNA biology. In addition, satDNAs in these organisms were shown to be closely linked to TEs. Employing different experimental and bioinformatic approaches, this research intends to explore the role of TEs in organization, propagation and evolution of satDNAs across a set of oyster species. We will examine the extent of “concerted evolution” and compare it between standalone and TE-incorporated satDNA arrays, both within and between species. The difference in the heterochromatin amount and content will be explored, and active parts of oyster mobilomes identified and compared. The study&#39;s findings will significantly advance our knowledge of repetitive genomic landscapes and their influence on chromosome structure. Importantly, comparative repeatomics will provide insights into the evolutionary processes and relationships of repetitive sequences in related species.]]></summary_en></project><project>
<id>18415</id><title_hr><![CDATA[Prirodna rješenja za dezinfekciju biofilma: inovativni pristup korak po korak]]></title_hr><title_en><![CDATA[Natural Solutions for Biofilm Disinfection: A Step-by-Step Innovative Approach]]></title_en><user_id>116</user_id><user_firstLast_name>Ivana Gobin</user_firstLast_name><svouser_id>868082</svouser_id><svouser_firstLast_name>Rok Fink</svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-4907</code><acronim><![CDATA[BiofilmClean ]]></acronim><duration>05.12.2025 - 04.12.2028</duration><status>U tijeku</status><financ_value>199.999,00 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Javno zdravstvo i zdravstvena zaštita, Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Public health and health services, Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Medicine]]></institution_en><team_members_id>865351, 867718, 870857, 12375, 1520, 19539, 17801, </team_members_id><team_members_names><![CDATA[Repac Antić Davorka, Mirna Petković Didović, Anamaria Trbović, Dolores Peruč, Zvonimir Marijanović, Ivana Jelovica Badovinac, Marina Pribanić Matešić, ]]></team_members_names><keywords_hr><![CDATA[antibakterijska aktivnost, biofilm, dezinfekcija, prirodne tvari, višestruko rezistentne bakterije]]></keywords_hr><keywords_en><![CDATA[Antimicrobial activity, Biofilm, Disinfection, Natural components, Multi-drug resistant bacteria]]></keywords_en><summary_hr><![CDATA[Razvoj bakterijskih biofilmova na kontaktnim površinama predstavlja sve veću ugrozu javnog zdravlja zbog sve veće rezistencije bakterija. Nastanak biofilma može se kontrolirati svakodnevnom uporabom dezinfekcijskih sredstava, no poznato je kako takve metode imaju negativne posljedice na okoliš i globalno javno zdravlje. Cilj istraživanja predloženog ovim projektom razvoj je inovativnog pristupa dezinfekciji koji omogućuje kontrolu nastanka i rasta biofilmova pomoću tvari prirodnog porijekla, manje štetnih od uobičajenih dezinficijensa. Tvari prirodnog porijekla manje su učinkovite, zbog čega je pristup temeljen na korak po korak strategiji koja podrazumijeva uporabu kombinacije odabranih prirodnih tvari u točno zadanom poretku. Prva faza istraživanja obuhvaća karakterizaciju materijala uobičajeno korištenih u bolnicama te pojedinih sojeva višestruko rezistentnih bakterija Staphylococcus aureus, Acinetobacter baumannii i Enterococcus faecalis. Na danim bi bakterijama zatim bila utvrđena učinkovitost standardnih dezinficijensa, kao polazišna točka za procjenu djelotvornosti slijedećih tvari: a) kiselina prirodnog porijekla (limunska, mliječna i octena kiselina); b) aktivnih komponenti biljnih metabolita (a-pinen, eugenol and karvakrol) i c) površinski aktivnih tvari biljnog podrijekla (polifilin D, ginsenosid-Rc, a-hederin). Citotoksičnost spojeva bit će ispitana na humanim keratocitima kako bi se utvrdile tvari s najmanjom toksičnošću. Zatim će se korak po korak inovativnim pristupom, po poretku uvjetovanom fiziologijom biofilma, ispitati učinkovitost kombinacija navedenih prirodnih tvari. Inovativnost ideje proizlazi iz mogućnosti značajnog povećanja dezinfekcijske učinkovitosti prirodnih tvari ukoliko se primjenjuju u optimalnom poretku. Ovaj bi pristup pridonio smanjenju ovisnosti o sintetskim dezinficijensima te pružio značajan doprinos u borbi protiv antimikrobne rezistencije]]></summary_hr><summary_en><![CDATA[Biofilms on contact surfaces pose a significant risk to public health as more and more bacteria become resistant. The use of many standard disinfectants in everyday life makes it possible to combat microorganisms, but this approach has a negative impact on the environment and global public health. The aim of this project is to develop an innovative approach to control harmful biofilms with substances of less hazardous natural origin through stepwise disinfection. Since the disadvantage of components of natural origin is their lower efficiency, the novel disinfection approach will be based on the stepwise application of selected compounds to increase the efficiency of these chemicals. First, we will characterise the properties of typical materials used in hospital environments and multidrug-resistant bacteria, S.  aureus, A. baumannii and E. faecalis. Next, we will evaluate the efficacy of standard disinfectants against the same bacteria. Secondly, the efficacy of acids of natural origin (citric acid, lactic acid and acetic acid), active components of plant metabolites (a-pinene, eugenol and carvacrol) and surface-active components of plants (polyphyllin D, ginsenoside-Rc, a-hederin) will be evaluated to achieve comparable results to classical disinfectants. We will also test all chemicals for their cytotoxic effect on human skin keratocytes to select the components with the lowest toxicity profile. As chemicals of natural origin have a lower potential against bacteria, we will perform a stepwise disinfection according to the physiological principles of the biofilm components. The ingenious idea lies in the fact that the efficacy of compounds of natural origin can be increased with the right sequential approach of applying the acid/active component of the essential oil/saponin. Such an approach not only reduces the reliance on antimicrobials but also represents a crucial step towards alleviating the antimicrobial crisis in public health.]]></summary_en></project><project>
<id>18420</id><title_hr><![CDATA[Primjena sinkroniziranih fazorskih mjerenja u distribucijskom sustavu]]></title_hr><title_en><![CDATA[Phasor Measurement Unit Applications for Distribution Systems ]]></title_en><user_id>7186</user_id><user_firstLast_name>Ninoslav Holjevac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2025-02</proposal_call><code>UIP-2025-02-5616</code><acronim><![CDATA[PMU-ADS]]></acronim><duration>01.04.2026 - 31.03.2031</duration><status>U tijeku</status><financ_value>299.148,85 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>25604, 7194, </team_members_id><team_members_names><![CDATA[Tomislav Baškarad, Matija Zidar, ]]></team_members_names><keywords_hr><![CDATA[sinkrofazorska mjerenja, dPMU mjerne jedinice, detekcija i lokacija mjesta kvara, vizualizacija stanja sustava, napredni nadzor]]></keywords_hr><keywords_en><![CDATA[synchrophasor measurements, dPMU, fault detection and location, wide-area visualization, advanced monitoring]]></keywords_en><summary_hr><![CDATA[Primjena sinkrofazorskih mjerenja (eng. Phasor measurement units – PMU) u distribucijskom sustavu podrazumijeva prilagodbu i razvoj načina korištenje fazorskih tehnologija i pristupa inicijalno namijenjenim za primjene u prijenosnom sustavu. Potreba za time proizlazi iz činjenice da se i u distribucijskom sustavu događaju značajne promjene potaknute masovnom integracijom distribuirane proizvodnje, prevladavajući iz obnovljivih izvora energije te značajnog rasta elektromobilnosti. Navedene promjene unose sve veću neizvjesnost u planiranje pogona distribucijskog sustava te raste potreba za boljom osmotrivosti sustava i boljom mogućnosti estimacije stanja. Upravo na ovim područjima uz primjenu fazorskih mjerenih uređaja prilagođenih za korištenje u distribucijskoj mreži (dPMU) je moguće ostvariti značajne iskorake te to predstavlja glavni cilj ovoga projekta unutar kojega će se razviti algoritmi i simulacijski okvir za estimaciju stanja i napredno vođenje i zaštitu distribucijskog sustava. Jednako tako, unutar projekta će se definirati glavni kriteriji i pogonski pokazatelji koji su potrebni za odabir opreme zadovoljavajućih karakteristika te će biti razvijen matematički okvir potreban za provedbu istraživanja i provedbu simulacija. Konačno razvojem testnog laboratorijskog dPMU sustava i odabirom testne lokacije teorijski koncepti i algoritmi će se testirati te će se izraditi prototip primjene za estimaciju i upravljanje distribucijskog sustava temeljenog na sinkro-fazorskim mjerenjima.]]></summary_hr><summary_en><![CDATA[The application of phasor measurement units (PMU) in the distribution system implies the adaptation and development of synchrophasor technologies and approaches initially intended for applications in the transmission system. The need for this stems from the fact that significant changes are also taking place in the distribution system, driven by the mass integration of distributed production, predominantly from renewable energy sources, and the significant growth of electromobility. The mentioned changes introduce more uncertainty into the planning of the distribution system operation, and thus the need for better observability of the system and a better possibility of state estimation is growing. Precisely in these areas, with the application of phasor measuring units adapted for use in the distribution network (dPMU), it is possible to make significant progress, and this represents the primary goal of this project, within which algorithms and a simulation framework will be developed for state estimation and advanced management and protection of the distribution system. Additionally, within the project, the main criteria and operating indicators necessary for selecting equipment with satisfactory characteristics will be defined, and the mathematical framework necessary for the implementation of research and simulations will be developed. Finally, by developing a test laboratory testbed dPMU system, theoretical concepts and algorithms will be tested, and a prototype application will be created for estimating the state and controlling of the distribution system based on synchrophasor measurements.]]></summary_en></project><project>
<id>18422</id><title_hr><![CDATA[Fizika strukturiranja aktivnih složenih membrana: Rekonstitucijski pristup]]></title_hr><title_en><![CDATA[Physics of Patterning Complex Active Membranes: A Reconstitution Approach]]></title_en><user_id>2682</user_id><user_firstLast_name>Ana-Sunčana Smith</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-3976</code><acronim><![CDATA[Phi-MemRecon]]></acronim><duration>15.12.2025 - 14.12.2028</duration><status>U tijeku</status><financ_value>196.549,75 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, Interdisciplinarne prirodne znanosti, </scie_field_hr><scie_field_en>Physics, Interdisciplinary natural sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>870744, 870900, 865729, 870951, </team_members_id><team_members_names><![CDATA[Piotr Nowakowski, Maja Milas, Blaž Ivšić, Kheya Sengupta, ]]></team_members_names><keywords_hr><![CDATA[biološke membrane, fazni prijelazi, teorijsko modeliranje i simulacije, mimetički sustavi, neravnotežna statistička fizika]]></keywords_hr><keywords_en><![CDATA[biological membranes, phase transitions, theoretical modeling and simulations, mimetic syestems, non-equilibrium statistical physics]]></keywords_en><summary_hr><![CDATA[Formiranje domena u staničnim membranama ključno je za prijenos signala i regulaciju sila važnih za mnoge procese, uključujući kretanje stanica i adheziju. Danas su poznati različiti mehanizmi koji vode k nehomogenoj organizaciji membrane. Međutim, membrane, koje sadrže više tipova proteina unutar smjese lipida i čije je ponašanje oblikovano aktivnim procesima, predstavljaju veliki izazov za eksperimentalne rekonstrukcije u neravnotežnim uvjetima, kao i za konceptualizaciju pomoću teorijskih modela. Postavljamo hipotezu da multi-lipidna i multi-proteinska složenost ovih membrana stvara okvir za samoizgradnju nakupina proteina kroz interakcije posredovane membranom. Osim toga, sugeriramo da stanični procesi dodatno pojačavaju ove učinke generiranjem naprezanja uvjetovanih lokalnim sastavom membrane. Kako bismo testirali ove hipoteze, oslonit ćemo se na vrlo uspješnu suradnju A. Smith s IRB-a u Zagrebu i K. Sengupte iz Marseillea. Korištenjem svog znanja u statističkoj fizici, biofizici, analitičkom i računalnom modeliranju, tim na IRB-u iskoristit će uvide iz eksperimenata K. Sengupte izvršenih na jedinstvenom modelnom sustavu – vezikulama izgrađenim od nekoliko vrsta lipida i kolesterola u kojima obitavaju kaderin i integrin receptori, dok se u unutrašnjosti polimerizira i depolimerizira aktin. Ponašanje tih vezikula motivirat će izradu teorijskog okvira za oblikovanje složenih, aktivnih membrana. To će uključivati razvoj koncepata neravnotežne fizike za izračunavanje faznih dijagrama pasivnih i aktivnih složenih sustava. Nadalje, oslonjeni na formalno ogrubljivanje razlučivosti teorije, unaprijedit ćemo naše pristupe kako bismo istražili utjecaj aktivnosti na organizaciju membrane, promjene oblika stanica, adheziju i mobilnost, kako je to prikazano u eksperimentima sa staničnim modelima I. Webera s IRB-a. Ova istraživanja dovest će do značajno dubljeg razumijevanja podrijetla proteinskih nakupina u staničnim membranama te njihovih veza s funkcijom stanica.]]></summary_hr><summary_en><![CDATA[Membrane patterning is essential for signal transduction and regulation of forces driving many processes, including cell movement and adhesion. Over time, a few mechanisms responsible for the formation of protein domains were identified. However, the complex membranes, which host multiple protein and lipid types while being shaped by active processes, have proven to be a major challenge for both experimental reconstitutions in non-equilibrium settings and for conceptualization using theoretical models. We here hypothesize that the multi-lipid and multi-protein complexity of these membranes creates a framework for self-organization through membrane-mediated interactions.  Additionally, we propose that cellular processes further enhance domain formation by stresses that couple to the local membrane composition. To test these hypotheses, we leverage the very successful collaboration of A. Smith at RBI Zagreb and K. Sengupta in Marseille. Building on its expertise in statistical physics, biophysics, analytical and computational modeling, the RBI team will utilize insights from K. Sengupta&#39;s experiments involving a unique model system—active giant unilamellar vesicles built from several lipids and hosting cadherins as well as integrins, encapsulating actin turnover. These experiments will motivate the construction of a theoretical framework for the patterning of complex, active membranes. This will involve the development of non-equilibrium physics concepts to calculate the phase diagrams of the passive and active complex systems. Furthermore, grounded in formal coarse-graining strategies, we will upscale our approaches to explore how activity influences membrane organization, cell shape changes, adhesion, and motility, as observed in experiments with cell models provided by an RBI collaborator I. Weber. Ultimately, this research will lead to a significantly deeper understanding of the origins of complex membrane patterning and its consequences on cell function.]]></summary_en></project><project>
<id>18423</id><title_hr><![CDATA[Inkluzivne šumske staze: Istraživanje utjecaja materijala, topografije i hrapavosti podloge staza na samostalno i sigurno kretanje osoba u invalidskim kolicima]]></title_hr><title_en><![CDATA[Inclusive Forest Trails: Exploring the Impact of Materials, Topography, and Surface Roughness of Trails on the Independent and Safe Mobility of Wheelchair Users]]></title_en><user_id>6557</user_id><user_firstLast_name>Kruno Lepoglavec</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-1748</code><acronim><![CDATA[Fors4Wheels]]></acronim><duration>30.01.2026 - 29.01.2029</duration><status>U tijeku</status><financ_value>177.273,50 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Šumarstvo, Interdisciplinarne biotehničke znanosti, </scie_field_hr><scie_field_en>Forestry, Interdisciplinary biotechnical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet šumarstva i drvne tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Forestry and Wood Technology]]></institution_en><team_members_id>6747, 6163, 26095, </team_members_id><team_members_names><![CDATA[Hrvoje Nevečerel, Matija Landekić, Anton Poje, ]]></team_members_names><keywords_hr><![CDATA[Pristupačnost, Osobe u kolicima, Šumske staze, Hrapavost podloge, Topografija, Vibracije, Sigurnost kretanja]]></keywords_hr><keywords_en><![CDATA[Accessibility, People in wheelchairs, Forest paths, Surface roughness, Topography, Vibrations, Safety movement]]></keywords_en><summary_hr><![CDATA[Pristupačnost šumskim površinama za osobe u kolicima predstavlja značajan problem zbog nedostatka adekvatne infrastrukture. Tema ovog istraživanja fokusira se na analizu utjecaja materijala, topografije, hrapavosti podloge šumskih staza i vibracija tijekom samostalnog kretanja osoba u invalidskim kolicima. Ova istraživanja ključna su za razvoj smjernica za inkluzivni dizajn šumskih staza, omogućujući osobama s invaliditetom da uživaju u prirodi, što je njihovo osnovno pravo. Osobe s invaliditetom suočavaju se s mnogim preprekama prilikom kretanja u prirodi, uključujući neprikladne nagibe, visoke rubnjake i staze koje nisu prilagođene. Osim toga, ne postoje jasno definirani zakonski i podzakonski akti o pristupačnosti za osobe u kolicima, kako na razini EU, tako i u Hrvatskoj, posebno glede pristupačnosti parkova i urbanih šuma.Istraživanje će se provesti u tri faze. Prva faza uključuje analizu materijala i površinskih karakteristika staza, ispitivanje hrapavosti putem Roughness Indexa. U drugoj fazi bit će analiziran utjecaj topografije i nagiba staza na samostalno kretanje, koristeći GNSS tehnologiju za precizna mjerenja. Treća faza istražuje vibracije i napor tijekom kretanja po različitim podlogama te njihovu povezanost s percepcijom sigurnosti korisnika, čime će se osigurati cjeloviti uvid u iskustva osoba s invaliditetom.Očekuju se rezultati o potrebnom dizajnu šumskih staza temeljem svih mjerenih kriterija koji će doprinijeti razvoju praktičnih smjernica za dizajn pristupačnih šumskih staza. Ovo istraživanje pomoći će u oblikovanju i implementaciji standarda koji osiguravaju sigurnost i samostalnost svih korisnika te stvoriti inkluzivne i pristupačne zelene površine, omogućujući osobama s invaliditetom potpuno sudjelovanje u svim aspektima društvenog života.]]></summary_hr><summary_en><![CDATA[Accessibility to forest areas for wheelchair users poses a significant problem due to the lack of adequate infrastructure. The focus of this research is on analyzing the impact of materials, topography, surface roughness of forest paths, and vibrations during the independent movement of individuals in wheelchairs. This research is crucial for developing guidelines for the inclusive design of forest paths, allowing persons with disabilities to enjoy nature, which is their fundamental right.Individuals with disabilities face many obstacles when moving in nature, including unsuitable slopes, high curbs, and pathways that are not designed to accommodate their needs. Furthermore, there are no clearly defined legal and sub-legal acts regarding accessibility for wheelchair users, both at the EU level and in Croatia, particularly concerning the accessibility of parks and urban forests.The research will be conducted in three phases. The first phase involves analyzing materials and surface characteristics of the paths, and examining their roughness using the Roughness Index. In the second phase, the impact of topography and slope of the paths on independent movement will be analyzed using GNSS technology for precise measurements. The third phase explores vibrations and effort during movement on various surfaces and their connection to users&#39; perceptions of safety, providing a comprehensive insight into the experiences of individuals with disabilities.Concrete results regarding the necessary design of forest paths based on all measured criteria will contribute to developing practical guidelines for designing accessible forest paths. This research will aid in shaping and implementing standards that ensure the safety and independence of all users, helping create inclusive and accessible green spaces, and enabling individuals with disabilities to fully participate in all aspects of social life.]]></summary_en></project><project>
<id>18425</id><title_hr><![CDATA[Infrastruktura istraživanja pomorske digitalizacije (MDigi-I) WP8 - Pilots and Infrastructure Performance Evaluation]]></title_hr><title_en><![CDATA[]]></title_en><user_id>21420</user_id><user_firstLast_name>Matko Orsag</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-6505</code><acronim><![CDATA[]]></acronim><duration>12.11.2025 - 11.11.2031</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>872934</team_members_id><team_members_names><![CDATA[ Doktorand: Pero Drobac ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>18430</id><title_hr><![CDATA[Agilna digitalizacija za kružno graditeljstvo: raspletanje kraja projekata]]></title_hr><title_en><![CDATA[Agile Digitalization for Circular Construction: Unraveling the End of Projects]]></title_en><user_id>1378</user_id><user_firstLast_name>Maja-Marija Nahod</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2025-02</proposal_call><code>UIP-2025-02-2415</code><acronim><![CDATA[ADiCu]]></acronim><duration>01.04.2026 - 31.03.2031</duration><status>U tijeku</status><financ_value>269.020,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Građevinarstvo, Interdisciplinarne tehničke znanosti, </scie_field_hr><scie_field_en>Civil engineering, Interdisciplinary technological sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Građevinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Civil Engineering]]></institution_en><team_members_id>2504, 870995, 871047, 870990, 11182, </team_members_id><team_members_names><![CDATA[Matej Mihić, Mladen Tomašković, Marina Džunić Matak, Romano Perić, Sandra Matuhina, ]]></team_members_names><keywords_hr><![CDATA[kružno graditeljstvo, agilni pristup, digitalizacija, održivi poslovni modeli, BIM ]]></keywords_hr><keywords_en><![CDATA[Circular construction, Agile approach,  Digitalization, Sustainable business models, Building Information Modeling (BIM)]]></keywords_en><summary_hr><![CDATA[Projekt ADiCu – Agilna digitalizacija za kružno graditeljstvo: raspletanje kraja projekata usmjeren je na inovativne pristupe integraciji kružnog gospodarstva u građevinsku industriju. Cilj je razviti poslovne modele, digitalne alate i regulatorne preporuke koji će omogućiti učinkovitije praćenje i ponovnu uporabu građevinskih elemenata nakon njihove demontaže ili uklanjanja s građevine. Istraživanje se provodi kroz agilni istraživački pristup, pri čemu će projektni tim raditi u mjesečnim sprintovima kako bi se osigurala brza prilagodba povratnim informacijama industrijskih partnera. Sektor graditeljstva se tradicionalno oslanja na rigidne upravljačke sustave. ADiCu uvodi agilnost u graditeljstvo kao put do kružnih praksi. Rezultati projekta dat će znanstveni i industrijski doprinos, uključujući publikacije u znanstvenim časopisima, testiranje modela te suradnju s dionicima iz privatnog i javnog sektora. ADiCu direktno pridonosi transformaciji industrije prema održivijim praksama.]]></summary_hr><summary_en><![CDATA[The ADiCu project – Agile Digitalization for Circular Construction: Unraveling the End of Projects focuses on innovative approaches to integrating circular economy principles into the construction industry. The goal is to develop business models, digital tools, and regulatory recommendations that will enable more efficient tracking and reuse of construction elements after their dismantling or removal from buildings. The research is conducted using an agile research approach - with monthly sprints to ensure rapid adaptation to feedback from industry partners. The construction sector has traditionally relied on rigid management, but ADiCu introduces agility as a pathway to circular practices. The project’s results will provide scientific and industrial contributions, including publications, model testing, and collaboration with stakeholders from the private and public sectors. ADiCu directly contributes to the transformation of the industry towards more sustainable practices.]]></summary_en></project><project>
<id>18431</id><title_hr><![CDATA[Relativistička nuklearna višečestična teorija u doba opažanja raznovrsnih signala]]></title_hr><title_en><![CDATA[]]></title_en><user_id>11296</user_id><user_firstLast_name>Nils Paar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-6795</code><acronim><![CDATA[RELANUM]]></acronim><duration>19.01.2026 - 18.01.2032</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>873068</team_members_id><team_members_names><![CDATA[ Doktorand: PAULA PEĆANIĆ ]]></team_members_names><keywords_hr><![CDATA[Nuklearna struktura, nuklearni prijelazi, višečestična teorija, energijski funkcional gustoće, nukleosinteza, neutronske zvijezde, supernova]]></keywords_hr><keywords_en><![CDATA[nuclear structure, nuclear transitions, many-body theory, density functional theory, nucleosynthesis, neutron stars, supernova]]></keywords_en><summary_hr><![CDATA[Razvoj novih eksperimentalnih postrojenja s radioaktivnim ionskim snopovima i opažanja raznovrsnih signala sa zvijezda pomoću detektora gravitacijskih valova, te opažanja rendgenskog zračenja, vidljivog svjetla, gama zračenja i neutrina, otvara nove perspektive za istraživanje ključnih pitanja u nuklearnoj astrofizici, posebice sinteze kemijskih elemenata težih od željeza u okruženjima supernove i dvojnih sustava neutronskih zvijezda. Glavni cilj ovog projekta je razviti univerzalnu mikroskopsku teoriju za opis slabo vezanih jezgara, njihovih pobuđenja, procesa slabog međudjelovanja, reakcija induciranih neutronima i nuklearne fisije u uvjetima konačne temperature u okruženju zvijezda, uključujući učinke deformacije i korelacija sparivanja, u formalizmu relativističkog energijskog funkcionala gustoće. Uspostavit će se novi teorijski pristup za istraživanje dinamike fisije s poboljšanim opisom učinaka disipacije, koji će omogućiti kvantitativni opis fisije jezgara odgovornih za recikliranje fisijom u procesu brzog uhvata neutrona. Ovim će se studijama uspostaviti veza između svojstava nuklearne fizike na konačnoj temperaturi opisanih u teoriji energijskog funkcionala gustoće i astrofizičkih modela evolucije zvijezda i nukleosinteze u supernovama i spajanju neutronskih zvijezda. Rezultati prvog opažanja gravitacijskih valova iz spajanja neutronskih zvijezda GW170817 i novi eksperimenti raspršenjenja elektrona s narušenjem pariteta, koristit će se za određivanje parametara nuklearne jednadžbe stanja, što je bitno za razumijevanje prirode zvijezda. Znanstveni ciljevi će se realizirati u interdisciplinarnom okviru teorijske nuklearne fizike i astrofizike koji objedinjuje modeliranje složenih sustava, strojno učenje i inovacije računalne znanosti primijenjene u distribuiranom računalnom okruženju. ]]></summary_hr><summary_en><![CDATA[The emergence of novel experimental facilities with radioactive ion beams and multimessenger observations of stellar objects with gravitational wave detectors, and X-ray, visibile light, gamma-rays and neutrino observations, open new perspectives to explore the key questions in nuclear astrophysics, in particular the synthesis of chemical elements heavier than iron in supernova and neutron star merger environments. The major goal of this project is to develop a universal microscopic theory framework to describe weakly bound nuclei, their excitations, weak interaction processes, neutron induced reactions and nuclear fission in finite temperature stellar conditions, including deformation effects and pairing correlations, in the formalism of the relativistic nuclear energy density functional. Novel theory framework will be established for description of the fission dynamics with improved description of the dissipation effects, that will allow quantitative description of the fission modes of nuclei responsible for the fission recycling in rapid neutron capture process. Through these studies, a link will be established between the nuclear physics properties at finite temperature described in the density functional theory and astrophysical models of stellar evolution and nucleosynthesis in supernovae and neutron-star mergers. The observables from the first measurement of gravitational waves from neutron star mergers GW170817, and new experiments with parity violating electron scattering, will be used to establish novel constraints on the nuclear equation of state, that is essential for understanding the nature of stars. Scientific objectives will be realized within the interdisciplinary framework of theoretical nuclear physics and astrophysics that unifies modeling of complex systems, machine learning, and computational science innovations applied in distributed computing environment. ]]></summary_en></project><project>
<id>18432</id><title_hr><![CDATA[Jezično variranje u hrvatskoj knjizi ranoga novog vijeka (na korpusu evanđelja)]]></title_hr><title_en><![CDATA[Language variation in Croatian books of the Early Modern period (based on the Gospels corpus)]]></title_en><user_id>2586</user_id><user_firstLast_name>Ivana Eterović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-2567</code><acronim><![CDATA[CroBiLex / CroBiLex]]></acronim><duration>21.01.2026 - 20.01.2029</duration><status>U tijeku</status><financ_value>179.870,76 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filologija, </scie_field_hr><scie_field_en>Philology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>12671, 5864, 24332, 7861, 1236, 15904, 870639, 11240, 870677, </team_members_id><team_members_names><![CDATA[Petra Bago, Vuk-Tadija Barbarić, Vera Blažević Krezić, Marijana Horvat, Tanja Kuštović, Mark Richard Lauersdorf, Nina Ledinek, Mateo Zagar, Alenka Jelovšek, ]]></team_members_names><keywords_hr><![CDATA[hrvatski jezik, 16. stoljeće, jezično variranje, biblijski prijevodi, rječnik, filologija, povijesna sociolingvistika, perceptivna dijalektologija]]></keywords_hr><keywords_en><![CDATA[Croatian language, 16th century, language variation, Bible translations, dictionary, philology, historical sociolinguistics, perceptual dialectology]]></keywords_en><summary_hr><![CDATA[Dosadašnja istraživanja hrvatskoga jezika u 16. st. pokazala su da se promjene u jezičnim stavovima prema različitim književnojezičnim varijetetima mogu osobito dobro pratiti na primjeru biblijskih prijevoda te da je u proučavanje nužno uključiti dosad manje proučene tekstove i slabije istražene jezične razine, među kojima je i leksička. Ciljevi su ovoga projektnog prijedloga razviti teorijsko-metodološka načela izrade rječnika hrvatskoga jezika ranoga novog vijeka; izraditi elektronički rječnik hrvatskih ranonovovjekovnih evanđeoskih tekstova; istražiti jezični i tekstološki kontinuitet hrvatskih predreformacijskih, reformacijskih i protureformacijskih biblijskih prijevoda; istražiti razine međudijalektne prilagodbe u hrvatskim ranonovovjekovnim biblijskim prijevodima; ispitati u kojoj mjeri jezično variranje u hrvatskim ranonovovjekovnim biblijskim prijevodima odražava šire društveno-povijesne prilike te promjenu u percepciji i oblikovanju hrvatskoga književnog jezika, i to sve na primjeru evanđelja. Korpus istraživanja obuhvatit će 10 hrvatskih biblijskih prijevoda 16. st., koji su sastavnim dijelom četiriju različitih tekstnih vrsta. Metodologija istraživanja toga korpusa bit će čvrsto utemeljena u tradicionalnoj filologiji, ali obogaćena suvremenim metodama i tehnikama povijesne sociolingvistike, perceptivne dijalektologije i digitalne humanistike. Izrađen rječnik hrvatskih ranonovovjekovnih evanđeoskih tekstova unijet će bitnu inovaciju u hrvatsku filologiju jer rječnik hrvatskoga jezika 16. stoljeća dosad ne postoji ni u kojem obliku. Sustavna i temeljita jezikoslovna i tekstološka istraživanja odabranoga korpusa unaprijedit će spoznaje o jezičnome variranju u hrvatskim ranonovovjekovnim biblijskim tekstovima, ali i pridonijeti razvoju metodologije povijesne perceptivne dijalektologije u međunarodnim razmjerima.]]></summary_hr><summary_en><![CDATA[Previous research on the Croatian language in the 16th century has shown that changes in linguistic attitudes towards different literary-language varieties can be particularly well observed using the example of Bible translations, and that it is necessary to include in the study texts that have been less examined so far and linguistic levels that have been less investigated, including the lexical level. The objectives of this project proposal are to develop theoretical and methodological principles for creating a dictionary of the Croatian language of the Early Modern period; create an electronic dictionary of Croatian early modern gospel texts; investigate the linguistic and textual continuity of Croatian pre-Reformation, Reformation and Counter-Reformation Bible translations; investigate the levels of interdialectal adaptation in Croatian early modern Bible translations; examine to what extent language variation in Croatian early modern Bible translations reflects the broader socio-historical context, and changes in the perception and formation of Croatian literary language, all using the example of the Gospels. The research corpus will include 10 Croatian Bible translations from the 16th century, which are an integral part of four different text types. The research methodology will be firmly based on traditional philology, but enriched with contemporary methods and techniques of historical sociolinguistics, perceptual dialectology and digital humanities. The created dictionary of Croatian early modern gospel texts will bring an important innovation to Croatian philology, because a dictionary of the Croatian language from the 16th century does not exist in any form to date. Systematic and thorough linguistic and textual research on the selected corpus will advance the knowledge about language variation in Croatian early modern biblical texts, but also contribute to the development of the methodology of historical perceptual dialectology on an international scale.]]></summary_en></project><project>
<id>18437</id><title_hr><![CDATA[Urbani toplinski otoci Mediterana i kontinenta Hrvatske]]></title_hr><title_en><![CDATA[Urban heat islands of the Mediterranean and continental Croatia]]></title_en><user_id>20341</user_id><user_firstLast_name>Andrija Krtalić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-8928</code><acronim><![CDATA[UTOMIKA]]></acronim><duration>31.12.2025 - 30.12.2028</duration><status>U tijeku</status><financ_value>199.962,50 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Geodezija, Arhitektura i urbanizam, Građevinarstvo, Računarstvo, Interdisciplinarne tehničke znanosti, </scie_field_hr><scie_field_en>Geodesy, Architecture and Urban Environment, Civil engineering, Computer sciences, Interdisciplinary technological sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu]]></institution_hr><institution_en><![CDATA[University of Zagreb]]></institution_en><team_members_id>870578, 865256, 6877, 20147, 25583, 870565, 870875, 26508, </team_members_id><team_members_names><![CDATA[Iva Cibilić, Katarina  Rogulj, Jelena Kilić Pamuković, Ljiljana Šerić, Ana Kuveždić Divjak, Antonia Ivanda, Majda Ćesić, Dubravka Maurer, ]]></team_members_names><keywords_hr><![CDATA[ Urbani toplinski otok, klima, daljinska istraživanja, otvoreni i komercijallni podaci, višekriterijalna analiza, strojno učenje]]></keywords_hr><keywords_en><![CDATA[ Urban heat island, climate, remote sensing, open and commercial data, multi-criteria analysis, machine learning]]></keywords_en><summary_hr><![CDATA[Na fenomen urbanih toplinski otoka (UTO) najviše utječu klima i urbanizacija, a oni pak utječu na zdravlje i kvalitetu života žitelja gradova. This phenomenon can be detected and monitored in a very simple way using remote sensing methods and free (free) data (Landsat satellite images) and software (QGIS), or using ready-made results of remote sensing methods (NDVI, LST, ECI). Međutim, procesi nastajanja UTO-a su puno kompleksniji postoji puno različitih čimbenika koji utječu na njihovu pojavu i utjecaj na okolinu. Zbog toga, cilj ovog projekta nije samo detektiranje novih i praćenje postojećih UTO-a, u administrativnim granicama mediteranskog grada Splita i kontinentalnog Hrvatskog grada Zagreba, nego provođenje višekriterijalne analize metodama strojnog učenja (engl. Machine Learning, ML) sa svim dostupnim parametrima koji utječu na njihovo stvaranje i interpretacije rezultata tih analiza u svrhu davanja smjernica za prevenciju nastanka i ublažavanje posljedica postojećih UTO-a. To je preduvjet za kreiranje sustava za potporu odlučivanju u prevenciji stvaranja novih UTO-a i praćenjem i ublažavanjem posljedica na okolinu postojećih UTO-a. U okviru projekta će se ispitati funkcionalne povezanosti velikog broja parametara koji utječu na stvaranje UTO-a (meteorološki podaci, satelitski snimci (dnevni i noćni), metapodaci satelitskih snimki, administrativni podaci (gustoća naseljenosti, stilovi građenja i građevinski materijali)); uspostavit će se kataloga poslužitelja otvorenih podataka za detektiranje, izdvajanje i analizu fenomena urbanih toplinskih otoka; detektirati, istaknuti i analizirati UTO-i na području gradova Splita i Zagreba metodama daljinskih istraživanja, od svibnja do rujna, u razdoblju od 1991. do 2027. godine.; izraditi digitalni atlasa usrednjenih NDVI, LST i ECI-a za područja Splita i Zagreba za isti period; odrediti i gradirati rizik od nastajanja fenomena UTO-a u Splitu i Zagrebu.]]></summary_hr><summary_en><![CDATA[The occurrence of urban heat islands (UHI) is mainly influenced by climate and urbanization, which in turn affects the health and quality of life of city residents. This phenomenon can be detected and monitored in a very simple way using remote sensing methods and free (free) data (Landsat satellite images) and software (QGIS), or using ready-made results of remote sensing methods (NDVI, LST, ECI). However, the processes of UTO formation are much more complex and there are many different factors that influence their occurrence and impact on the environment. Therefore, the goal of this project is not only to detect new and monitor existing UTOs, in the Mediterranean city of Split and the continental Croatian city of Zagreb, but also to conduct multi-criteria analysis using machine learning (ML) methods with all available parameters that influence their creation and to interpret the results of these analyses in order to provide guidelines for preventing the occurrence and mitigating the consequences of existing UTOs. This is a prerequisite for creating a decision support system for preventing the creation of new UTOs and monitoring and mitigating the environmental consequences of existing UTOs. The project will examine the functional connections of a large number of parameters that influence the creation of UHIs (meteorological data, satellite images (day and night), satellite image metadata, administrative data (population density, building styles and construction materials)); establish a catalogue of open data servers for detecting, highlight and analyzing the phenomenon of UHI; detect, highlight and analyze UHIs in the areas of the cities of Split and Zagreb using remote sensing methods, from May to September, in the period from 1991 to 2027; create a digital atlas of averaged NDVI, LST and ECI for the areas of Split and Zagreb for the same period; determine and grade the risk of the occurrence of the UHI phenomenon in Split and Zagreb.]]></summary_en></project><project>
<id>18439</id><title_hr><![CDATA[Društvena odgovornost i profesionalna etika hrvatskih istraživača]]></title_hr><title_en><![CDATA[]]></title_en><user_id>18914</user_id><user_firstLast_name>Marija Brajdić Vuković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-3698</code><acronim><![CDATA[RESETH]]></acronim><duration>01.12.2025 - 30.11.2030</duration><status>U tijeku</status><financ_value>60,00 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Sociologija, </scie_field_hr><scie_field_en>Sociology, </scie_field_en><institution_hr><![CDATA[Institut za društvena istraživanja]]></institution_hr><institution_en><![CDATA[Institute for Social Research in Zagreb]]></institution_en><team_members_id>872918</team_members_id><team_members_names><![CDATA[ Doktorand: Magda Profaca ]]></team_members_names><keywords_hr><![CDATA[društvena odgovornost znanosti, znanost i društvena kriza, odgovorni istraživački proces, kreativne istraživačke metode, RRI IMAGINE]]></keywords_hr><keywords_en><![CDATA[social responsibility of science, science and social crises, responsibile research process, creative research methods, RRI IMAGINE]]></keywords_en><summary_hr><![CDATA[Glavni istraživački fokus ovog projekta jest pitanje što znači biti društveno odgovoran istraživač i kako društvenu odgovornost znanosti opisuju, doživljavaju i prakticiraju hrvatski istraživači iz prirodnih, biomedicinskih, tehničkih i društvenih znanosti. Osnova društvene odgovornosti znanosti u našem poimanju povezana je s profesionalnom etikom znanosti kroz vrijednosti, stavove i ponašanje istraživača. Naš projekt istražuje što je društveno odgovoran istraživač odozdo prema gore, kao smisao i sadržaj koji dolazi iz same znanstvene zajednice i kroz njezinu svakodnevnu istraživačku praksu. U Hrvatskoj nema istraživačkih projekata, analiza ili teorijskih radova koji su bili dubinski fokusirani na temu društvene odgovornosti hrvatskih znanstvenika. I u međunarodnom kontekstu studije na znanstvenicima o društvenoj odgovornosti znanosti rijetke su te se uglavnom odnose na znanosti o životu i biotehnologiju i provedene su na relativno malim uzorcima. Praktično nema studija o društvenoj odgovornosti znanosti u vrijeme društvenih kriza kao što je pandemija Covid-19. Znanstveni ciljevi projekta su dati uvid u značenja koja hrvatski istraživači pridaju društvenoj odgovornosti znanosti, te u svjetlu recentne, i budućih društvenih kriza. Zatim, opisati procese, iskustva, te ponašanja u vezi s društvenom odgovornošću prije i tijekom istraživačkog procesa i u rezultatima, te komunikaciji s javnošću. Ovaj će projekt također opisati i analizirati društvenu odgovornost znanosti u nacionalnom kontekstu. Osim anketa i polu-strukturiranih intervjua, koristit ćemo kreativne metode istraživanja. Širi društveni ciljevi su doprinijeti politikama društvene odgovornosti znanosti u Hrvatskoj, doprinijeti pojačanoj refleksivnosti znanstvenika o odnosu znanosti i društva i ulozi znanosti u društvu, te doprinijeti idejama vezanim uz angažman i ulogu javnosti u sustavu znanosti.]]></summary_hr><summary_en><![CDATA[The main research focus of this project is at what it means to be a socially responsible researcher and how the social responsibility of science is understood, described, experienced and practiced by Croatian researchers in the natural, biomedical, technical, and social sciences. The basis of the social responsibility of science is connected with the professional ethics of science through the values, attitudes and behavior of researchers. Our project explores what a socially responsible researcher is from the bottom up, as meaning and content that comes from the scientific community itself and through its everyday research practice. In Croatia, there are no research projects, analyses or theoretical works that are deeply focused on the topic of social responsibility of scientists. Even in the international context, studies on scientists are rare and mostly refer to life sciences and biotechnology and have been conducted on relatively small samples. There are practically no studies on the social responsibility of science in times of social crises such as the Covid-19 pandemic. The scientific goals of the project are to provide insight into the meanings that Croatian researchers attach to social responsibility, and in the light of recent and future social crises. Further, to describe the processes, experiences, and behaviors related to social responsibility before and during the research process and in public outreach. This project will also analyze the social responsibility of science in the national context. Together with surveys and semi-structured interviews, we will use creative research methods. Broader social goals are to contribute to policies related to the social responsibility of science in Croatia, to contribute to the reflexivity of scientists about the relationship between science and society and the role of science in society, and to contribute to ideas related to the role of the public in the science system.]]></summary_en></project><project>
<id>18442</id><title_hr><![CDATA[Konačnoelementni modeli za analizu stabilnosti tankostjenih kompozitnih grednih konstrukcija]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3329</user_id><user_firstLast_name>Domagoj Lanc</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-2236</code><acronim><![CDATA[STACOBEAM]]></acronim><duration>01.12.2025 - 30.09.2031</duration><status>U tijeku</status><financ_value>70,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Temeljne tehničke znanosti, </scie_field_hr><scie_field_en>Basic engineering sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Tehnički fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Engineering]]></institution_en><team_members_id>872940</team_members_id><team_members_names><![CDATA[ Doktorand: Raul Ivan Gašljević ]]></team_members_names><keywords_hr><![CDATA[kompozitne gredne konstrukcije, analiza stabilnosti, tankostjeni poprečni presjek, laminatni kompoziti, FG kompoziti, gredni konačni element]]></keywords_hr><keywords_en><![CDATA[composite beam-type structures, stability analysis, thin-walled cross-section, laminate composites, FG composites, beam finite element]]></keywords_en><summary_hr><![CDATA[Projekt će se baviti razvojem numerički model za analizu stabilnosti tankostjenih grednih i okvirnih konstrukcija sastavljenih od nebalansiranih i nesimetričnih laminatnih kompozita te FG (functionally graded) kompozita u režimima promjenjive temperature i vlažnosti. Numerički algoritmi temeljit će se na prostornom tankostjenom grednom konačnom element s 14 stupnjeva slobode gibanja. Kao mjera za opisivanje deformacije koristit će se Green-Lagrangeova tenzor deformacije, dobiven na temelju nelinearnog polja pomaka kompozitnog tankostjenog poprečnog presjeka koje uključuje efekte velikih prostornih rotacija i vitoperenja. Za dobivanje ravnotežnih jednadžbi prostornog grednog konačnog elementa bit će primijenjen princip virtualnih radova i updated Lagrangian inkrementalna deskripcija. Kod nelinearne analize stabilnosti koristiti će se inkrementalno-iterativne procedure rješavanja nelinearnog sustava algebarskih jednadžbi. Za provođenje force recovery procedure koristit će se transformacijska matrica temeljena na polutangencijalnim rotacijama, koje su energijski konjugirane s polutangencijalnim momentima i imaju svojstvo komutativnosti.]]></summary_hr><summary_en><![CDATA[The project will deal with the development of a numerical model for stability analyzing of thin-walled beam and frame structures composed of unbalanced and asymmetrical laminate composites, and of FG (functionally graded) composites under regimes of variable temperature and moisture. Numerical algorithms will be based on a spatial thin-walled beam finite element with 14 degrees of freedom of motion. As a strain measure, the Green-Lagrange strain tensor will be used, obtained on the basis of the nonlinear displacement field of the composite thin-walled cross-section, which includes the effects of large spatial rotations an warping. To obtain the equilibrium equations of the spatial beam finite element, the principle of virtual works and the updated Lagrangian incremental description will be applied. In the nonlinear stability analysis, incremental-iterative procedures for solving the nonlinear system of algebraic equations will be used. To perform the force recovery procedure, a transformation matrix based on semi-tangential rotations will be used, which are energetically conjugated with semi-tangential moments and have the property of commutativity.]]></summary_en></project><project>
<id>18446</id><title_hr><![CDATA[Istraživanja temeljnih elektroničkih svojstava u kvantnim materijalima: topološki sustavi i šire]]></title_hr><title_en><![CDATA[Exploring Fundamental Electronic Properties in  Quantum Matter: Topological  Systems and Beyond]]></title_en><user_id>1173</user_id><user_firstLast_name>Mario Novak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-3955</code><acronim><![CDATA[EFE-Quantum]]></acronim><duration>30.01.2026 - 29.01.2029</duration><status>U tijeku</status><financ_value>199.870,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>5009, 866120, 2873, 866053, 865961, 868100, 4157, 13228, 870718, 870829, 23130, </team_members_id><team_members_names><![CDATA[Ivan Kokanović, Petar Sačer, Nikolina Novosel, Nikolina Penić, Akio Kimura, Ondrej Caha, Željana Bonačić Lošić, Maja Varga Pajtler, Damian Rybicki, Andrej Pustogow, Bruno Gudac, ]]></team_members_names><keywords_hr><![CDATA[Diracovi polumetali, topološki materijali, sinteza materijala, jedinični kristali, električna transportna svojstva, magnetska svojstva]]></keywords_hr><keywords_en><![CDATA[Dirac semimetals, topological materials, material synthesis, single crystals, electrical transport properties, magnetic properties.]]></keywords_en><summary_hr><![CDATA[Ovaj projekt usmjeren je na dvije vrste materijala:Istraživat ćemo odabrane topološke izolatore birane zbog njihovih optimalnih svojstava—uključujući veličinu energetskog procjepa te Diracovu točku i Fermi novo smješten unutar procjepa. Naš cilj je razviti pouzdane tehnike za precizno kontroliranje položaja Fermi nivoa  pomoću kemijskog dopiranja i „ion-loquid gating“ metode. Osim toga, želimo uspostaviti jednostavnu i točnu metodu za određivanje položaja Fermi nivoa površinskih stanja.Na temelju naših nedavnih rezultata (Gudac et al., arXiv:2411.05207), predlažemo korištenje Seebeckova efekta kao novog i pouzdanog alata za ispitivanje kemijskog potencijala u režimu dominantnog površinskog transporta. Ovaj pristup omogućit će nam sustavno istraživanje intrinzičnih topoloških efekata, poput planarnog Hallovog efekta, u ovisnosti o položaju kemijskog potencijala. Nadalje, ovu metodu ćemo primijeniti na proučavanje utjecaja jednoosnog naprezanja na zaštićena  spin-momentum  površinska Diracova stanja.Drugi ključni fokus naše studije su magnetski topološki materijali, posebice spojevi poput EuCd2As2, kontroverznog materijala koji je predviđen kao Weylov polumetal. Međutim, naši nedavni rezultati dovode u pitanje tu interpretaciju, sugerirajući alternativne mehanizme iza njegovih nekonvencionalnih svojstava. S obzirom na aktualnu raspravu, cilj nam je temeljito istražiti magnetska i električna transportna svojstva EuCd2As2 i srodnih spojeva.Ključni cilj je odrediti osnovno magnetsko uređenje i razviti metodu za njegovo podešavanje – prijelaz iz antiferomagnetskog (AFM) u feromagnetsko (FM) stanje – kroz preciznu kontrolu kemijskog dopiranja i uvjeta sinteze. To je od velikog općeg interesa za razumijevanje neobičnih svojstava ovog materijala i iskorištavanje njegovih magneto-optičkih svojstava.Osim toga, želimo razumjeti naše preliminarno opažanje snažnog anomalnog Hallovog efekta (AHE) u paramagnetskoj fazi EuCd2As2 i istražiti kako jednoosno naprezanje utječe na AHE.]]></summary_hr><summary_en><![CDATA[This project focus on two types of materials:We will investigate selected topological insulators choosen for their optimal properties—including an appropriately sized energy gap, and  Dirac point and  Fermi level positioned within the gap. Our initial goal is to develop reliable techniques for precisely controlling the Fermi level position through chemical doping and ionic liquid gating. Additionally, we aim to establish a simple and accurate method for determining the Fermi-level position of surface states.Building on our recent findings (Gudac et al., arXiv:2411.05207), we propose using the Seebeck effect as a novel and reliable tool for probing the chemical potential in a surface-transport-dominant regime. This approach will enable us to systematically explore intrinsic topological effects, such as the planar Hall effect, as a function of the chemical potential position. Furthermore, we will apply this method to study the impact of uniaxial strain on spin-momentum locking protection in surface Dirac fermions. A second key focus of our study is magnetic topological materials, particularly compounds such as EuCd2As2, a controversial material predicted to be a Weyl semimetal. However, our recent results challenge this interpretation, suggesting alternative mechanisms behind its unconventional properties. Given the ongoing debate, we aim to thoroughly investigate the magnetic and electrical transport properties of EuCd2As2 and related compounds.A central objective is to determine the ground-state magnetic ordering and establish a method for tuning it - switching from AFM to FM state—through precise control of chemical doping and synthesis conditions. This is of great general interest for understanding the unusual properties of this material. and utilizing its magnetoptical properties. Additionally, we seek to understand our preliminary observation of a strong anomalous Hall effect (AHE) in the paramagnetic phase of EuCd2As2 and use uniaxial strain influence the AHE.]]></summary_en></project><project>
<id>18450</id><title_hr><![CDATA[Strah divlje svinje od lova: utjecaj na korištenje prostora, stres i kvalitetu mesa]]></title_hr><title_en><![CDATA[]]></title_en><user_id>19869</user_id><user_firstLast_name>Toni Safner</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-9752</code><acronim><![CDATA[WBfearHUNT]]></acronim><duration>12.12.2025 - 11.12.2031</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Agronomski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Agriculture]]></institution_en><team_members_id>872989</team_members_id><team_members_names><![CDATA[ Doktorand: Martina Tunjić ]]></team_members_names><keywords_hr><![CDATA[Sus scrofa, skupni lov, pojedinačni lov, lovački pas, prostorno ponašanje, stres, GPS telemetrija, DNK metabarkodiranje, kortizol, kvaliteta mesa]]></keywords_hr><keywords_en><![CDATA[Sus scrofa, drive hunt, single hunt, hunting dog, spatial behaviour, stress, GPS telemetry, DNA metabarcoding, cortisol, meat quality ]]></keywords_en><summary_hr><![CDATA[Lov može dovesti do promjena u demografiji, distribuciji, ponašanju i fiziologiji divljih životinja. Osobito kada se provode veliki skupni lovovi s lovačkim psima, mogu izazvati bihevioralne i fiziološke reakcije divljih svinja. Doista, lov može utjecati na prostorno ponašanje, korištenje prostora, ritam aktivnosti, prehrambene navike i izazvati fiziološke reakcije zbog povećanog stresa, što zauzvrat utječe i na dobrobit životinja i na kvalitetu mesa. Znanje o učinku različitih metoda lova na bihevioralne i fiziološke reakcije divljih svinja vrlo je ograničeno. To je posebno izazovno jer vrsta ima veliki potencijal za prijenos bolesti od javnog i gospodarskog značaja. U predloženom projektu, vodeći stručnjaci za divlje svinje u Hrvatskoj, Sloveniji i Švicarskoj razvit će originalni dizajn studije kako bi kombinirali bihevioralne, molekularne i fiziološke podatke, s ciljem razumijevanja ekologije i odgovora divljih svinja izloženih različitim metodama lova. Predloženi projekt pridonijet će boljem razumijevanju učinaka metoda lova na prostorno ponašanje, potencijal rasprostranjenosti i ekologiju kretanja divljih svinja, izloženost stresu kao i na kvalitetu mesa. Bit će to prvi koji će definirati sveobuhvatne interakcije između divljih svinja i lovačkih pasa tijekom lova. Dobiveni rezultati i intenzivne aktivnosti širenja koristit će donositeljima odluka, dionicima, upraviteljima populacije, lovcima i mesnoj industriji kako bi se utvrdile odgovarajuće prakse upravljanja utemeljene na dokazima i znanosti kako bi se smanjili učinci vrlo važnog čimbenika izazivanja stresa i posljedično povećala dobrobit životinja, kao i za dobivanje najkvalitetnijeg mesa za daljnju preradu. Ono što je važno, projekt će biti ugrađen u postojeću Paneuropsku mrežu koja ima za cilj poboljšati širenje informacija o prostornom ponašanju divljih svinja među istraživačima i dionicima, a čemu je tim već pridonio.]]></summary_hr><summary_en><![CDATA[Hunting can lead to changes in the demography, distribution, behaviour and physiology of wildlife. Especially when conducted as large drive hunts with hunting dogs, can cause behavioural and physiological responses of wild boar. Indeed, hunting can affect spatial behaviour, space use, activity rhythms, feeding habits, and cause physiological responses due to increased stress, which in turn affects both animal welfare and quality of meat. Knowledge on the effect of different hunting methods on behavioural and physiological responses of wild boar is very limited. This is particularly challenging as the species has a great potential for transmission of diseases of both public and economic health concern. In the proposed project, leading wild boar experts in Croatia, Slovenia, Switzerland will develop an original study design to combine behavioural, molecular and physiological data, aiming to understand the ecology and responses of wild boar exposed to different hunting methods. The proposed project will contribute to a better understanding of the effects of hunting methods on spatial behaviour, dispersal potential and movement ecology of wild boar, exposure to stress as well as on the meat quality. It will be the first one which will define comprehensive interactions between wild boar and hunting dogs during drive hunts. Results obtained and intensive dissemination activities will benefit decision makers, stakeholders, population managers, hunters, and meet industry to determine appropriate, evidence- and science-based management practices both to decrease effects of a very important stress-inducing factor and consequently increase animal welfare, as well as to obtain the best quality meat for further processing. Importantly, the project will be embedded in existing pan-European networks that aim to improve the dissemination of information on the spatial behaviour of wild boar among researchers and stakeholders, and to which the team has already contributed.]]></summary_en></project><project>
<id>18451</id><title_hr><![CDATA[Mehanokemijske reakcije boronskih kiselina s aminima i karbonilnim spojevima praćene in situ Ramanovom spektroskopijom]]></title_hr><title_en><![CDATA[Mechanochemical Reactions of Boronic Acids with Amines and Carbonyl Compounds Monitored in Situ by Raman Spectroscopy]]></title_en><user_id>1007</user_id><user_firstLast_name>Marina Juribašić Kulcsar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-3843</code><acronim><![CDATA[MECHBORON]]></acronim><duration>10.12.2025 - 09.12.2028</duration><status>U tijeku</status><financ_value>199.935,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>625, 2740, 3061, 23120, 112, 854, </team_members_id><team_members_names><![CDATA[Ivan Halasz, Sunčica Roca, Ana Budimir, Senada Muratović, Manda Ćurić, Darko Babić, ]]></team_members_names><keywords_hr><![CDATA[mehanokemija, spektroskopija, praćenje, sinteza, boronske kiseline, amini, karbonilni spojevi]]></keywords_hr><keywords_en><![CDATA[mechanochemistry, spectroscopy, monitoring, synthesis, boronic acids, amine, carbonyl compound]]></keywords_en><summary_hr><![CDATA[Amini, boronske kiseline i karbonilni spojevi bit će građevni elementi u reakcijama dva istaknuta borova reagensa, 2-formilfenilboronske kiseline (FBA) i bisboronske kiseline (BBA). Ovi se reagensi često koriste u reakcijama u otopini dok će njihove reakcije u čvrstom stanju biti istražene u okviru predloženog projekta.FBA je važan reagens u dinamičkoj kovalentnoj kemiji i bioortogonalnoj kemiji za vezanje obilježivača na biomolekule. Primjena FBA se temelji na njezinoj reakciji s aminima gdje nastaju N-iminoboronati, poznati po selektivnom vezanju diola, posebice šećera. Proučavat će se reakcije važne za primjenu FBA: reakcije FBA s diolima, hidrazinima i hidroksiaminima te 2-aminoderivatima alkohola, tiola i amina. Istraživat će se nastajanje i stabilnost cikličkih produkata i izmjena vezanih derivata amina, s fokusom na spojeve koji se koriste u biološkim sustavima.BBA, poznat kao reducens i borilacijski agens, i/ili njegovi esteri ispitat će se i kao reagensi u multikomponentnim reakcijama u uvjetima sinteze u čvrstom stanju.Ispitat će se fotokemijske [2+2] cikloadicije alkenilamina omogućene nastanjem reaktivnih B<-N adukata s derivatima boronskih kiselina. Reakcije će se provoditi u kugličnom mlinu i pratiti in situ Ramanovom spektroskopijom i ex situ difrakcijskim i spektroskopskim metodama kako bi se omogućila karakterizacija vrsta uključenih u reakcije, te dobio uvid u tijek reakcije i čimbenike koji kontroliraju reaktivnost i selektivnost. Priprava odabranih produkata s potencijalnom biološkom ili farmaceutskom primjenom testirat će se i na većoj skali u ekstruderu. Iste će se reakcije testirati u otopini i pratiti spektroskopijama NMR i/ili UV-vis. Kvantno-kemijski računi koristit će se za racionalizaciju eksperimentalnih podataka.Razvijene mehanokemijske metode omogućit će ekološki prihvatljiv pristup istraživanim spojevima. Osim toga, razumijevanje reakcijske dinamike značajno će pomoći budućem dizajnu reakcija s borovim reagensima u čvrstom stanju.]]></summary_hr><summary_en><![CDATA[Amines, boronic acids and carbonyl compounds will be used as building blocks for reactions of two emerging boron reagents: 2-formylphenylboronic acid (FBA) and bisboronic acid (BBA). These compounds are frequently used in solution, but their solid-state reactions have yet to be studied.FBA is important in dynamic covalent chemistry and bioorthogonal chemistry for bonding markers to biomolecules. FBA application is based on its reaction with amines to form N-iminoboronates, which are known to selectively bind diols, especially sugars. Reactions of FBA important for its application will be studied: reactions with diols, hydrazines, hydroxyamines and 2-amino derivatives of alcohols, thiols and amines. Formation and stability of cyclic products and exchange of bound amine derivatives will be investigated, focusing on compounds used in biological systems.BBA, known as reductant and borylation agent, and/or its esters will be tested as reagents in solid-state multicomponent reactions.Photomechanochemical [2+2] cycloaddition of alkenylamines facilitated by formation of B<-N adducts with boronic acid derivatives will be studied.Reactions will be carried out in a ball mill and monitored by in situ Raman spectroscopy and ex situ diffraction and spectroscopic methods in order to characterize species involved in the reactions, and gain insight into the reaction course and factors that control reactivity and selectivity. Preparation of selected products with potential biological or pharmaceutical application will be tested on a larger scale in the extruder. Selected reactions will be run in solution and monitored by NMR and/or UV-vis spectroscopies. Quantum chemical calculations will be used to rationalize the experimental data. The developed mechanochemical methods will enable environmentally friendly access to the investigated compounds. In addition, understanding the reaction dynamics will be valuable in the future design of solid-state reactions with boron reagents.]]></summary_en></project><project>
<id>18452</id><title_hr><![CDATA[Dinamika (nano)čestica u urbanim okolišima: Integrativni pristup]]></title_hr><title_en><![CDATA[Dynamics of (Nano)Particles in Urban Environments: An Integrative Approach]]></title_en><user_id>4415</user_id><user_firstLast_name>Maja Ivanić</user_firstLast_name><svouser_id>870647</svouser_id><svouser_firstLast_name>Martin Gaberšek</svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-4178</code><acronim><![CDATA[CityDust]]></acronim><duration>10.12.2025 - 09.12.2028</duration><status>U tijeku</status><financ_value>198.145,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, Interdisciplinarne prirodne znanosti, </scie_field_hr><scie_field_en>Chemistry, Interdisciplinary natural sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>868251, 870634, 13139, 2669, 5151, 13361, </team_members_id><team_members_names><![CDATA[Karim Benzerara, Claire Carvallo, Hana Fajković, Goran Durn, Mavro Lučić, Frane Marković, ]]></team_members_names><keywords_hr><![CDATA[urbano zagađenje, nanočestice, mikroplastika, lebdeće čestice, geokemija]]></keywords_hr><keywords_en><![CDATA[urban pollution, nanoparticles, microplastics, airborne particles, geochemistry]]></keywords_en><summary_hr><![CDATA[Onečišćenje zraka predstavlja globalnu opasnost za okoliš i zdravlje ljudi. Međunarodne organizacije kontinuirano predstavljaju nove direktive i strategije za ublažavanje tih utjecaja i poboljšanje kvalitete zraka. Među najkritičnijim onečišćivačima zraka su lebdeće čestice (PM), klasificirane kao PM10 i PM2.5, pri čemu potonje predstavljaju veći rizik za ljudsko zdravlje. U urbanim područjima, sinergijskim djelovanjem antropogenih aktivnosti, prirodnih procesa i klimatskih čimbenika, njihove koncentracije često premašuju sigurne granice. Među najzabrinjavajućim i najmanje istraženim lebdećim česticama nalaze se nanočestice i mikroplastika. Ovaj projekt ima za cilj istražiti sastav i dinamiku anorganskih lebdećih čestica, nanočestica i mikroplastike u urbanim područjima pod različitim antropogenim pritiscima (urbani, industrijski i turistički) i različitim klimatskim uvjetima (ljeto-zima). Tijekom studije uzorkovat će se i analizirati lebdeće čestice, čestice taložene na vegetaciji i prašina s ceste. Dodatno, uzorkovanjem kiše i snijega istražit će se utjecaj oborina na prijenos čestica. Analiza oborinskih voda pružit će podatke o potencijalnom utjecaju ovih čestica na okoliš. Kvantitativna i kvalitativna mikrobiološka analiza lebdećih čestica pružit će informacije o njihovoj potencijalnoj ulozi u širenju patogena i/ili alergena. Metodologija istraživanja temeljit će se na tehnikama elektronske mikroskopije (SEM, SEM-EDS, TEM), Raman spektroskopije, magnetskim mjerenjima i ICP-QQQ s jedinično-čestičnim modom. Rezultati će pružiti nove uvide u podrijetlo, prijenos i kruženje anorganskih lebdećih čestica, nanočestica i mikroplastike u urbanim područjima, ulogu oborina u njihovoj pretvorbi i transportu te potencijala njihovog ispuštanja u okoliš preljevanjem oborinskih voda–problem koji pogoršavaju klimatske promjene. Stečeno znanje omogućit će bolje strategije upravljanja usmjerene na smanjenje njihovih koncentracija u zraku i ublažavanju utjecaja na okoliš.]]></summary_hr><summary_en><![CDATA[Air pollution is a major global environmental and health hazard. International organizations continuously develop new policies and strategies to mitigate its impact and improve air quality. One of the most critical air pollutants is particulate matter (PM), classified as PM10 and PM2.5, with the latter posing a greater risk to human health. In urban areas, PM concentrations often exceed safe limits due to the synergistic effects of anthropogenic activities, natural processes and climate factors. Among the most concerning and least studied components of airborne PM are nanoparticles (NP) and microplastics.This project aims to investigate the composition and dynamics of inorganic PM, NPs and microplastics in urban areas under varying anthropogenic pressures (urban, industrial and tourism) and different climate conditions (summer-winter). The study will sample and analyse airborne PM, PM deposited on vegetation and road dust. In addition, the influence of precipitation on the transfer of particulates will be investigated by sampling rain and snow. The analysis of stormwater will provide information on the potential impact of PM on the environment. Quantitative and qualitative microbiological analysis of airborne PM will provide information on the potential role of PM on the spread of pathogens and/or allergens.The research methodology will ba based on electron microscopy techniques (SEM, SEM-EDS, TEM), Raman spectroscopy, magnetic measurements and ICP-QQQ with a single particle mode.The results will offer new insights into the origin, transfer and cycling of inorganic PM, NPs and microplastics in urban areas, the role of precipitation in their transformation and transport, and the potential for their release into the environment through stormwater overflows – an issue exacerbated by climate change. The knowledge gained will enable better management strategies aimed at reducing airborne PM concentrations and mitigating its impact on the environment.]]></summary_en></project><project>
<id>18455</id><title_hr><![CDATA[Specijalizirani laboratorij za rekonstrukciju i istraživanje neutrona]]></title_hr><title_en><![CDATA[Dedicated Laboratory for Neutron Reconstruction and Study]]></title_en><user_id>193</user_id><user_firstLast_name>Deša Jelavić Malenica</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2025-02</proposal_call><code>UIP-2025-02-5203</code><acronim><![CDATA[DAENERYS]]></acronim><duration>01.04.2026 - 31.03.2031</duration><status>U tijeku</status><financ_value>299.998,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, Interdisciplinarne prirodne znanosti, </scie_field_hr><scie_field_en>Physics, Interdisciplinary natural sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>868173, </team_members_id><team_members_names><![CDATA[Andrea Horvat, ]]></team_members_names><keywords_hr><![CDATA[detekcija neutrona, rekonstrukcija neutrona, analiza putanja više neutrona, strojno učenje, neutroni iz fisije, struktura lakih jezgara]]></keywords_hr><keywords_en><![CDATA[neutron detection, neutron reconstruction, multi-neutron tracking, machine learning, neutrons from fission, light nuclei structure]]></keywords_en><summary_hr><![CDATA[Ovaj projekt predlaže osnivanje laboratorija DAENERYS, specijaliziranog istraživačkog centra pri Institutu Ruđer Bošković (IRB) u Hrvatskoj, usmjerenog na inovacije u detekciji i rekonstrukciji neutrona. Laboratorij će omogućiti znanstvene iskorake integracijom umjetne inteligencije i naprednih algoritama strojnog učenja kako bi se unaprijedila rekonstrukcija višestrukih neutrona te razvile preciznije, učinkovitije i prilagodljive eksperimentalne tehnike i postavi. Time će se značajno povećati dosezi istraživanja neutrona i njihov doprinos suvremenoj nuklearnoj fizici.Posebno osmišljen eksperimentalni postav na IRB-u omogućit će izravna mjerenja neutrona u malim eksperimentima, služeći kao platforma za razvoj i testiranje naprednih algoritama rekonstrukcije te optimizaciju detektorskih konfiguracija. Podaci prikupljeni iz ovih eksperimenata pridonijet će boljem razumijevanju uloge neutrona u klasteriranju lakih jezgri te unaprijediti metode rekonstrukcije i povećati učinkovitost detekcije neutrona u budućim istraživanjima.Podaci koji zahtijevaju složenije i resursno zahtjevne eksperimente prikupljat će se kroz postojeće i buduće međunarodne suradnje, omogućujući pristup vrhunskim istraživačkim infrastrukturama. Paralelno, tehnike rekonstrukcije testirat će se i unaprijediti kroz različite detektorske sustave i reakcijske uvjete, čime će se osigurati njihova prilagodljivost širokom spektru eksperimentalnih scenarija.Vizija DAENERYS-a usklađena je s globalnim naporima unapređenja eksperimenata u nuklearnoj fizici kroz preciznu detekciju neutrona. Razvojem inovativnih metoda rekonstrukcije i njihovom integracijom u lokalne i međunarodne eksperimente, ovaj će projekt učvrstiti ulogu Hrvatske u ovom iznimno izazovnom i brzo rastućem znanstvenom području.]]></summary_hr><summary_en><![CDATA[This proposal aims to establish DAENERYS, a specialized laboratory at the Ruđer Bošković Institute (RBI) in Croatia, focused on innovating neutron detection and reconstruction. The lab will drive scientific advancements by integrating AI and advanced machine learning algorithms to enhance multi-neutron tracking and develop more precise, efficient, and scalable techniques and experimental setups — amplifying the impact of neutron research across the field. A dedicated setup at RBI will enable direct neutron-inclusive measurements for small-scale experiments, serving as a platform for developing and testing advanced reconstruction algorithms and optimizing detector configurations. Benchmarking data from these experiments will improve our understanding of neutrons&#39; role in the clustering of light nuclei, enhancing reconstruction techniques and enabling more efficient neutron detection in future experiments.Data requiring more complex and costly setups will be sourced through existing and future international partnerships, ensuring broader access to large-scale cutting-edge experiments while allowing us to test and refine our reconstruction techniques across different detector systems and reaction conditions.The vision of DAENERYS aligns with the global push toward precision neutron physics. By developing innovative neutron reconstruction methodologies and integrating them into both local and large-scale experiments, this project will establish Croatia’s role in this highly challenging and rapidly evolving field.]]></summary_en></project><project>
<id>18460</id><title_hr><![CDATA[Habsburška birokracija i lokalne zajednice: županije Banske Hrvatske]]></title_hr><title_en><![CDATA[The Habsburg Bureaucracy and Local Communities: Counties of Banal Croatia]]></title_en><user_id>24923</user_id><user_firstLast_name>Željko Holjevac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-1386</code><acronim><![CDATA[CBC]]></acronim><duration>29.12.2025 - 28.12.2028</duration><status>U tijeku</status><financ_value>127.709,00 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Povijest, </scie_field_hr><scie_field_en>History, </scie_field_en><institution_hr><![CDATA[Institut društvenih znanosti Ivo Pilar]]></institution_hr><institution_en><![CDATA[Institute of Social Sciences Ivo Pilar in Zagreb]]></institution_en><team_members_id>2739, 6522, 25731, 1005, 4836, 870136, 870561, 870560, 5855, 20099, 870082, 870223, 870377, 870547, 870603, </team_members_id><team_members_names><![CDATA[Ljiljana Dobrovšak, Mislav Gabelica, Ivan Brlić, Vijoleta Herman Kaurić, Branko Ostajmer, Vladimir Huzjan, Filip Šimetin Šegvić, Nikolina Šimetin Šegvić, Željko Bartulović, Luka Pejić, Željko Karaula, Marianna Nagy, Adam Schwarczwolder, FILIP KATANIĆ, Ivan Bubalo, ]]></team_members_names><keywords_hr><![CDATA[Austro-Ugarska, Banska Hrvatska, činovništvo, elite, javna uprava, lokalna samouprava, županije]]></keywords_hr><keywords_en><![CDATA[Austria-Hungary, Banal Croatia, bureaucracy, elites, public administration, local self-government, counties]]></keywords_en><summary_hr><![CDATA[Svrha je projekta potaknuti sustavna istraživanja hrvatsko-slavonskih županija (Ličko-krbavska županija, Modruško-riječka županija, Zagrebačka županija, Varaždinska županija, Bjelovarsko-križevačka županija, Požeška županija, Virovitička županija i Srijemska županija) u razdoblju od 1886. do 1918. pomoću suvremenih pristupa i novih spoznaja utemeljenih na rezultatima izvornih znanstvenih istraživanja. Glavni cilj projekta je istražiti kako je poslovao habsburški birokratski aparat u županijama, kakav je učinak imalo upravljanje javnim poslovima u lokalnim zajednicama i koliko je bilo samouprave u županijama. Banska Hrvatska potkraj 19. i početkom 20. stoljeća bila je autonomna kraljevina u sklopu Zemalja ugarske krune kao sastavnog dijela Austro-Ugarske. Stoga je hrvatsko-slavonsko županijsko činovništvo pripadalo birokratskom aparatu u kasnom habsburškom carstvu. Metodologija istraživanja temeljit će se na istraživačkom radu koji će uključivati istraživanje primarnih izvora pohranjenih u arhivima, knjižnicama, muzejima i specijalnim zbirkama u Hrvatskoj, Mađarskoj, Austriji i Srbiji. Ti će izvori uključivati tiskana godišnja izvješća, izvorno arhivsko gradivo, statističke godišnjake, novine i druge pisane dokumente. Iako su ti materijali dragocjeni za nijansirano razumijevanje razvojnih procesa u Hrvatskoj tijekom La Belle Époque u Europi, oni su prilično zanemareni u hrvatskoj historiografiji. Planirana istraživanja će za početak obuhvatiti tri specifična aspekta: 1. županijsko činovništvo (profil i karijere županijskih činovnika), 2. trajanja i promjene u lokalnim zajednicama (u područjima kao što su školstvo, zdravstvena skrb, šumarstvo, graditeljstvo i slični javni poslovi u županijama) i 3. županijska samouprava (županijske skupštine i županijski pravni akti). ]]></summary_hr><summary_en><![CDATA[The purpose of the project is to encourage systematic research on the Croatian-Slavonian counties (Lika-Krbava County, Modruš-Rijeka County, Zagreb County, Varaždin County, Bjelovar-Križevci County, Požega County, Virovitica County, and Syrmia County) in the period from 1886 to 1918 using modern approaches and new insights based on the results of original scientific research. The general objective of the project is to investigate how the Habsburg bureaucratic apparatus operated in these counties, what impact the public administration had on local communities, and to what extent self-governance existed in the counties. At the end of the 19th and the beginning of the 20th century, Banal Croatia was an autonomous kingdom within the Lands of the Hungarian Crown as part of Austria-Hungary. Therefore, the county administration in Croatia-Slavonia of that time was part of the bureaucratic system of the late Habsburg Empire. The research methodology will be based on investigative work that includes the examination of primary sources stored in archives, libraries, museums, and special collections in Croatia, Hungary, Austria, and Serbia. These sources will include printed annual reports, original archival records, statistical yearbooks, newspapers, and other written documents. Although these materials are valuable for a nuanced understanding developmental processes in Croatia during the Beautiful Era in Europe, they have been largely neglected in Croatian historiography. Therefore, the planned research will initially focus on three specific aspects: 1. County administration (profiles and careers of county officials), 2. Duration and changes in local communities (in areas such as education, healthcare, forestry, civil engineering, and other public affairs within the counties), and 3. County self-government (county assemblies and county legal acts).]]></summary_en></project><project>
<id>18461</id><title_hr><![CDATA[Amplifikacija seizmičkoga gibanja tla uzrokovana topografskim efektima u Sjevernoj Hrvatskoj]]></title_hr><title_en><![CDATA[]]></title_en><user_id>25746</user_id><user_firstLast_name>Davor Stanko</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-2377</code><acronim><![CDATA[SIGMATOPCRO]]></acronim><duration>01.11.2025 - 31.10.2031</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Geofizika, </scie_field_hr><scie_field_en>Geophysics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Geotehnički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Geotechnical Engineering]]></institution_en><team_members_id>872910</team_members_id><team_members_names><![CDATA[ Doktorand: Laura Novak ]]></team_members_names><keywords_hr><![CDATA[Sjeverna Hrvatska, Lokalizirana topografska oštećenja od potresa, Seizmičko gibanje tla, Topografska amplifikacija, Topografski hazard ]]></keywords_hr><keywords_en><![CDATA[North Croatia, Localized topographic earthquake damage patterns, Seismic ground motion, Topographic amplification, Topographic hazard]]></keywords_en><summary_hr><![CDATA[Nakon potresa u Zagrebu i Petrinji 2020., brojne crkve, kulturne i povijesne građevine (posebno izgrađene prije 1964.) diljem Sjeverne Hrvatske pretrpjele su štetu (oštećenje krovova, dimnjaka i neojačanih zidova). U usporedbi sa značajkama lokalnog tla (stijena, nizina, kotlina...), većina oštećenih sakralnih objekata i starijih građevina u Sjevernoj Hrvatskoj nastala je na istaknutim topografskim lokalitetima/uzvisinama. Amplifikacija seizmičkoga gibanja tla uzrokovana topografskim efektima može biti značajna na planinskim vrhovima, brežuljcima, padinama, grebenima i liticama te čak može biti jednaka ili jača u odnosu na amplifikaciju uzrokovanu rastresitim sedimentima. Na temelju makroseizmičkih opažanja lokaliziranih topografskih oštećenja od potresa, pet (5) najzanimljivijih topografskih lokaliteta u različitim područjima i epicentralnim zonama u Sjevernoj Hrvatskoj bit će odabrano za detaljna istraživanja. Metodološki pristupi istraživanja za procjenu amplifikacije seizmičkog gibanja tla uzrokovane topografskim nepravilnostima terena bit će podijeljeni u nekoliko istraživačkih ciljeva: makroseizmička opažanja praćena multidisciplinarnim terenskim istraživanjima, mjerenja mikroseizmičkog nemira i uspostava kontinuiranog seizmičkog monitoringa u svrhu analize topografskog modela, numeričkog modeliranja i statističkih procjena topografskog hazarda te GIS mapiranja. Važan aspekt projekta bit će kreiranje strukturirane baze podataka sa svim relevantnim informacijama, podacima, rezultatima te mikrozonacijskim kartama koja se može koristiti kao smjernica za buduća istraživanja i primjene. Potresi iz 2020. (Zagreb i Petrinja) uzrokovali su goleme ekonomske geoinženjerske efekte i povezane posljedice. Od velike je važnosti provesti ovakva jedinstvena i inovativna multidisciplinarna istraživanja koja će biti primjenjiva za prevenciju i smanjenju katastrofa potresa, te primjenu u projektima oporavka i rekonstrukcije u pogođenim stratigrafskim i topografskim područjima.]]></summary_hr><summary_en><![CDATA[Following the moderate Zagreb and strong Petrinja 2020 earthquakes, numerous churches, cultural and historical buildings (especially those built before 1964) throughout Northern Croatia reported damage. When compared to other sites (rock sites, lowlands, basins etc.), a sizable amount of recorded damage to churches and older buildings in Northern Croatia occurred on irregular topographic features. Seismic ground motion amplification induced by topographic irregularity can be significant on mountain tops, peaky hills, slopes, ridges, and cliff faces, and can be equally or more important than amplification caused by sedimentary stratigraphic effects. Based on macroseismic observations on localized topographical damage patterns from historical and recent earthquakes, five most interesting topographic localities in different areas and epicentral zones in Northern Croatia will be chosen for case-by-case studies. Research methodological approaches to estimate amplification of seismic ground motion induced by topographic irregularity will be divided into several research objectives: macroseismic observations followed by multidisciplinary field investigations, ambient noise measurements and continuous seismic monitoring for the purpose of topographic model analysis, numerical modelling, statistical topographic hazard assessments, and GIS mapping solutions. Major aspect of this project will be creation of open access database in which all relevant information’s, data, results and topographic microzonation maps will be structured that can be used as a guideline for future research studies and applications. Zagreb and Petrinja 2020 earthquakes caused massive economic geoengineering effects and associated consequences. It is of great significance to perform such unique and innovative multidisciplinary research to be applicable for the prevention and reduction of earthquake disasters as well for recovery and reconstruction in affected stratigraphic and topographic areas. ]]></summary_en></project><project>
<id>18465</id><title_hr><![CDATA[Metabolomika ciljnih tkiva u spolno specifičnoj predikciji rizika za dijabetes tipa 2 i neurodegeneraciju u odgovoru na zapadnjačku i keto prehranu]]></title_hr><title_en><![CDATA[Metabolomics of Targeted Tissues in Sex-Specific Prediction of Type 2 Diabetes and Neurodegeneration Risk in Response to Western and Keto Diets]]></title_en><user_id>4409</user_id><user_firstLast_name>Marija Heffer</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-7869</code><acronim><![CDATA[MeDiet]]></acronim><duration>10.12.2025 - 09.12.2028</duration><status>U tijeku</status><financ_value>196.334,84 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, Clinical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Medicinski fakultet Osijek]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Medicine]]></institution_en><team_members_id>4511, 4384, 19985, 4439, 2737, 868143, 4420, 868657, 866621, 868654, 4417, 866522, 870543, 26097, 4379, </team_members_id><team_members_names><![CDATA[Vedrana Ivić, Marta Balog, Ines Bilić-Ćurčić, Barbara Viljetić, Jasenka Wagner Kostadinović, Viktoria Čurila, Irena  Labak, Lovro Mihajlović, Ivana  Marković, Vinko Krajina, Robert Blažeković, Dražen  Mlinarević, Darija Balonek-Nikolić, Krešimir Šolić, Senka Blažetić, ]]></team_members_names><keywords_hr><![CDATA[metabolički poremećaj, neurodegeneracija, prehrana, žučne kiseline, kolesterol, štakorski model]]></keywords_hr><keywords_en><![CDATA[metabolic disorder, neurodegeneration, diet, bile acids, cholesterol, rat model]]></keywords_en><summary_hr><![CDATA[Dijabetes tipa 2 (DM2) čimbenik je rizika za Alzheimerovu bolesti (AD). Obje bolesti dijele zajedničke patofiziološke mehanizme. Nedostajuća znanja u njihovom razvoju uključuju: nerazumijevanje uloge prehrane, spolno specifičnih čimbenika i biljega za ranu dijagnozu i praćenje. Ovom studijom želi se istražiti uloga metabolizma kolesterola i žučnih kiselina u odgovoru na starenje i prehranu. Prvi cilj je odrediti spolno i dobno specifične razlike metabolizma kolesterola i žučnih kiselina na modelu Sprague Dowley štakora uspoređujući mlade i srednjovječne životinje oba spola. Drugi cilj je odrediti spolno i tkivno specifični odgovor na standardnu (StD), keto (KD) i dijetu bogatu mastima i šećerima (HFHSD) te identificirati potencijalne biomarkere (žučne kiseline/oksisterole) za praćenje težine metaboličkog poremećaja u serumu, urinu i stolici. StD i KD će se koristiti kao protektivne u odnosu na HFHSD. Razvoj DM2 pratit će se poznatim pokazateljima metaboličkog poremećaja i metabolomskom spektrometrijskom (LC-MS) analizom seruma, urina i fecesa. Disbalans osovine kolesterol – žučne kiseline utvrdit će se testovima mitohondrijske funkcije, histološkim, imunokemijskim i metabolomskim analizama (LC-MS, MALDI-TOF, IMS) ciljnih organa. Poremećaj strukture staničnih membrana analizirat će se na razini sastava lipidnih splavi. Kognitivne funkcije pratit će se bihevioralnim testovima te metabolomskom i imunokemijskom analizom molekula vezanih za plastičnost mozga. Očekujemo da će sveobuhvatna analiza omogućiti identifikaciju patofizioloških mehanizama metaboličkog disbalansa koji doprinose kognitivnom poremećaju. Spolno specifični biljezi metabolizma kolesterola i žučnih kiselina mogu poslužiti kao bolji prediktori ranog nastupa AD i kao temelj za personalizaciju dijagnostike i terapije. Kako su obje bolesti, DM2 i AD, multifaktorijalne, istraživački tim čine biolozi, kemičari, neuroznanstvenici, medicinski biokemičari i kliničari. ]]></summary_hr><summary_en><![CDATA[Diabetes type 2 (T2D) is a risk factor for Alzheimer’s disease (AD). Both conditions share common pathophysiological mechanisms. Knowledge gaps in the development of both diseases include: lack of understanding on the role of diet, sex-specific factors, and biomarkers of early diagnosis and follow-up. This study aims to investigate the role of cholesterol and bile acid metabolism in response to aging and diet. Objective 1 is to determine sex and age-specific differences in cholesterol and bile acid metabolism using the Sprague-Dawley rat model by comparing young and middle-aged animals of both sexes. Objective 2 is to identify sex and tissue-specific responses to standard diet (StD), keto diet (KD), and a high-fat high-sugar diet (HFHSD), as well as to identify potential biomarkers (bile acids/oxysterols) for monitoring the severity of metabolic disorder in serum, urine, and feces. StD and KD will be used as protective diets compared to HFHSD. The development of T2D will be monitored through known indicators of metabolic disorder and spectrometric (LC-MS) analysis of serum, urine, and fecal samples. The dysregulation of the cholesterol-bile acid axis will be assessed using mitochondrial function tests, immunohistochemical, and metabolomics (LC-MS, MALDI-TOF, IMS) of target organs. Cellular membrane structure will be analyzed at the level of lipid raft composition. Cognitive functions will be evaluated using behavioral, metabolomics and immunohistochemical analyses of molecules related to brain plasticity. The comprehensive analysis will identify pathophysiological mechanisms of metabolic imbalance contributing to cognitive impairment. Sex-specific biomarkers of cholesterol and bile metabolism will serve as better predictors of the early onset of AD and form the basis for personalized diagnostics and therapy. Given that both T2D and AD are multifactorial diseases, the research team includes biologists, chemists, neuroscientists, medical biochemists, and clinicians.]]></summary_en></project><project>
<id>18469</id><title_hr><![CDATA[Procjena dugotrajnog učinka klimatskih i antropogenih utjecaja na prostorno-vremensku dinamiku vegetacijskog pokrova u Hrvatskoj korištenjem satelitskih opažanja]]></title_hr><title_en><![CDATA[]]></title_en><user_id>20306</user_id><user_firstLast_name>Mateo Gašparović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-6693</code><acronim><![CDATA[ALCAR]]></acronim><duration>01.01.2026 - 01.01.2032</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Geodezija, </scie_field_hr><scie_field_en>Geodesy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Geodetski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Geodesy]]></institution_en><team_members_id>872905</team_members_id><team_members_names><![CDATA[ Doktorand: Ivana Jarak ]]></team_members_names><keywords_hr><![CDATA[daljinska istraživanja, vegetacija, klimatske promjene, antropogeni učinci, pokrov i upotreba zemljišta]]></keywords_hr><keywords_en><![CDATA[remote sensing, vegetation, climate change, anthropogenic effects, land use land cover]]></keywords_en><summary_hr><![CDATA[Satelitska daljinska istraživanja predstavljaju neizbježan globalni izvor sinoptičkih podataka koji omogućuju retrospektivnu analizu dinamike kopnene površine pod vegetacijom te povezanih biogeofizičkih i biogeokemijskih procesa. Daljinska istraživanja omogućuju prikupljanje dugoročnih opažanja Zemlje, kao i informacije o unutarsezonskoj dinamici vegetacije ili &#39;&#39;fenologiji kopnene površine&#39;&#39;. Budući da trenutno ne postoje studije na nacionalnoj razini s vrlo visokom prostornom osjetljivošću na promjene zemljišnog pokrova kao posljedice povijesnih političkih i socioekonomskih trendova, ovim projektom upotrijebit će se najnovija dostignuća u suvremenom prediktivnom modeliranju i strojnom učenju. U tom smislu, glavni znanstveno-istraživački ciljevi projekta su:• Razviti tehnički okvir, temeljen na dugoročnom promatranju Zemlje i naprednoj obradi podataka, statističkim i algoritmima strojnog učenja, za procjenu prostorno-vremenske dinamike zemljišnog pokrova uslijed institucionalnih promjena i regionalnih utjecaja globalnih promjena okoliša.• Osigurati rezultate koji omogućuju preciznu procjenu utjecaja, ranjivosti i sposobnosti prilagodbe glavnih tipova vegetacije i klasa uporabe zemljišta (šume, poluprirodna područja i poljoprivredna područja) u regionalnim okruženjima okoliša u Hrvatskoj.• Razviti sustave ranog upozoravanja za poljoprivredu i šumarstvo temeljene na meteorološkim podacima gotovo u stvarnom vremenu i kratkoročnim predikcijama fenoloških reakcija.Projekt se temelji na postavljenim hipotezama:• Je li moguće procijeniti dugoročne klimatske i antropogene učinke na kopnenu površinu pod vegetacijom iz prostorno-vremenskih podataka promatranja površine Zemlje?• Je li moguće odrediti stupanj prilagodbe pojedinog vegetacijskog tipa na klimatske promjene? Koje su vrste šuma i poljoprivrednih kultura najmanje, a koje najviše pogođene klimatskim promjenama?• Je li moguće dati kratkoročnu predikciju utjecaja klime na tipove vegetacije?]]></summary_hr><summary_en><![CDATA[Satellite remote sensing presents an inevitable global source of synoptic data that enable retrospective characterization into the dynamics of the vegetated land surface and associated biogeophysical and biogeochemical processes. Remote sensing enables acquisition both of long-term observations and information about the intra-seasonal dynamics of vegetation, or “land surface phenology”. Since there are no existing nationwide studies with very high spatial sensitivity of the land cover changes as a consequence of historical political and socio-economic trends, this project project will use recent advances in state-of-the-art predictive modelling and machine learning. In that sense, the main scientific research objectives of the project are:• To develop technical framework, based on the long-term Earth observation and advanced data processing, statistical and machine learning algorithms, for evaluation of the spatio-temporal land cover dynamics due to institutional changes and regional impacts of global environmental change.• To provide results that enable precise evaluation of the impact, vulnerability and adaptation capacity of the main vegetation types and land-use classes (forests, semi natural areas and agriculture areas) across the regional environmental settings in Croatia.• To develop early warning systems for agriculture and forestry based on near-real-time meteorological data and short-term forecasting of phenological responses.The project is based on stated hypotheses:• Is it possible to assess the long-term climatic and anthropogenic effects on the spatio-temporal vegetated land surface earth observation data?• Is it possible to determine degree of adaptation of each vegetation type to climate change? Or simplified. Which forest type and agricultural crops are least and most affected by climate change?• Is it possible to provide short-term forecasting of climate impacts on vegetation classes?]]></summary_en></project><project>
<id>18471</id><title_hr><![CDATA[FITNESS - Flexible InteligenT NEar-field Sensing Skins]]></title_hr><title_en><![CDATA[]]></title_en><user_id>378</user_id><user_firstLast_name>Ivan Petrović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-4939</code><acronim><![CDATA[]]></acronim><duration>19.03.2026 - 18.03.2032</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>874028</team_members_id><team_members_names><![CDATA[ Doktorand: Ivan Bilić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>18473</id><title_hr><![CDATA[Klima i ekstremni vremenski uvjeti u prirodnom i urbanom okolišu Hrvatske ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>2650</user_id><user_firstLast_name>Ivana Herceg Bulić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-6771</code><acronim><![CDATA[CroClimExtremes ]]></acronim><duration>01.02.2026 - 31.01.2032</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Geofizika, </scie_field_hr><scie_field_en>Geophysics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>873049</team_members_id><team_members_names><![CDATA[ Doktorand: Karla Mlađen ]]></team_members_names><keywords_hr><![CDATA[Klima, ekstremi, urbana područja, planinska područja, morska razina ]]></keywords_hr><keywords_en><![CDATA[Climate, extremes, urban areas, mountainous areas, sea level]]></keywords_en><summary_hr><![CDATA[Projekt se bavi klimatskim promjenama i vremenskim ekstremima u iznimno ranjivim dijelovima okoliša (gradovi, planinska područja i more). Sastoji se od četiri modula unutar kojih će se istraživati teme koje su važne za širu znanstvenu zajednicu, ali su ujedno od posebnog značaja za Hrvatsku: 1. atmosferski procesi velike prostorne skale koji podržavaju razvoj ekstremnih uvjeta na području Europe, 2. utjecaj ekstremnih vremenskih događaja na klimatska obilježja gradova u Hrvatskoj – toplinski valovi, intenzivna kratkotrajna oborina, združeni i uzastopni ekstremi, 3. utjecaj atmosferskih procesa na pojavu iznimnih vodostaja u Jadranu, 4. pojava opasnih vremenskih prilika u prirodnom okolišu kompleksne topografije (planina Biokovo). Osmišljen je interdisciplinarni pristup koji će provoditi multidisciplinarna grupa iskusnih domaćih i inozemnih znanstvenika sa znanjima i kompetencijama iz različitih područja (klimatologija, meteorologija, oceanografija, fizika, geografija, matematika), mladih znanstvenika na početku karijere (doktorandi) te također mladih, ali iskusnijih znanstvenika (poslijedoktorandi). Unaprijedit će se i primijeniti metodologije za istraživanje navedenih tema, analizirat će se empirijski i modelirani podaci te će se provoditi klimatsko modeliranje atmosferskim modelom opće cirkulacije ICTP AGCM i urbanim klimatskim modelom MUKLIMO. Osigurat će se kontinuirana mjerenja morske razine u Bakru. Na planini Biokovo će se uspostaviti mreža mjernih instrumenata, što predstavlja prvu mrežu planinskih mjerenja takvog opsega u Hrvatskoj. Na odabranoj će se lokaciji uz šetnicu SkyWalk postaviti meteorološka postaja s prijenosom podataka u realnom vremenu. Važan cilj projekta je izobrazba mladih znanstvenika koji će prijenosom znanja i vještina od iskusnijih suradnika ojačati svoje znanstvene kompetencije. Posebno će se voditi računa o diseminaciji rezultata, vidljivosti projekta, edukaciji i suradnji s potencijalnim korisnicima rezultata istraživanja. ]]></summary_hr><summary_en><![CDATA[The project deals with climate change and weather extremes in highly vulnerable parts of the environment (cities, mountainous areas and the sea). Topics important for the wider scientific community, but particularly Croatia, will be researched through four modules: 1. large-scale atmospheric processes supporting development of extremes in Europe, 2. the impact of extreme weather events on the climatic characteristics of Croatian cities – heat waves, intense precipitation, compound and successive extremes, 3. the atmospheric influence on the occurrence of extreme sea-levels in the Adriatic, 4. dangerous weather conditions in the natural environment of complex topography (Mount Biokovo). An interdisciplinary approach has been devised, which will be carried out by a multidisciplinary group of experienced domestic and foreign scientists with competencies in various fields (climatology, meteorology, oceanography, physics, geography, mathematics), young scientists (PhD students) and young experienced scientists (postdoctoral students). Methodologies for the research of the mentioned topics will be improved and applied, empirical and modelled data will be analysed and climate modelling will be carried out using the global model ICTP AGCM and the urban climate model MUKLIMO. Continuous measurements of the sea level in Bakar, Croatia, will be ensured. A network of measuring instruments will be established on Mount Biokovo, which represents the first network of mountain measurements of such scope in Croatia. Additionally, a weather station with real-time data transmission will be set up near the Biokovo viewpoint SkyWalk. An important goal of the project is the education of young scientists who will strengthen their scientific competencies by transferring knowledge and skills from experienced colleagues. Special attention will be paid to the dissemination of results, visibility of the project, education, and cooperation with potential users of research results.]]></summary_en></project><project>
<id>18474</id><title_hr><![CDATA[Towards safe, optimized and personalized radiology and radiotherapy procedures for pregnant patients]]></title_hr><title_en><![CDATA[]]></title_en><user_id>11070</user_id><user_firstLast_name>Hrvoje Brkić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-3911</code><acronim><![CDATA[]]></acronim><duration>01.12.2025 - 30.11.2031</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Medicinski fakultet Osijek]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Medicine]]></institution_en><team_members_id>872935</team_members_id><team_members_names><![CDATA[ Doktorand: Ivor Dukić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>18476</id><title_hr><![CDATA[Univerzalnosti u nastajanju u sustavima s jakim međudjelovanjima]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6532</user_id><user_firstLast_name>Ivan Balog</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-7306</code><acronim><![CDATA[UniSyS]]></acronim><duration>15.01.2026 - 30.04.2030</duration><status>U tijeku</status><financ_value>51,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut za fiziku]]></institution_hr><institution_en><![CDATA[Institute of Physics in Zagreb]]></institution_en><team_members_id>872312</team_members_id><team_members_names><![CDATA[ Doktorand: Lovro Šaravanja ]]></team_members_names><keywords_hr><![CDATA[funkcionalna renormalizacijska grupa, klase univerzalnosti, fazni prijelazi, rijetki događaji, neuređeni sustavi, kvantni fazni prijelazi, ab-initio]]></keywords_hr><keywords_en><![CDATA[functional renormalization group, universality classes, phase transitions,rare events, disordered systems, quantum phase transitions, ab-initio]]></keywords_en><summary_hr><![CDATA[   Razumijevanje i predviđanje fizikalnih svojstava materijala ogroman je izazov zbog njihove složenosti na molekularnoj, strukturnoj, elektronskoj i spinskoj razini. Postoje dva glavna teorijska pristupa razumijevanju takvih kompleksnih materijala, ovisno o tome rješava li se problem s makroskopskog i) ili mikroskopskog ii) stajališta.   i) Kako je “više drugačije”, od mnogih mikroskopskih sastojaka novonastalo makroskopsko ponašanje vrlo je teško predvidjeti. Ipak, u prirodi se opažaju univerzalna ponašanja a priori vrlo različitih sustava u prirodi. Univerzalnost je tako nađena u vrlo različitim kontekstima, u rasponu problema u statističkoj i čvrstostanjskoj fizici, fizici visokih energija, biofizici i ekonofizici. Za opis ovakvih ponašanja Renormalizacijska grupa je metoda od našeg izbora, jer utjecaje mikroskopskih detalja potiskuje na krupnije prostorne skale, iznjedrujući pri tome efektivne makroskopske modele.   ii) S mikroskopske strane, ab initio računi danas sve brže napreduju. Međutim, za mnoge materijale od suvremenog znanstvenog interesa to je još uvijek nedovoljno. Zato je orijentacija u suvremenim teorijskim istraživanjima kondenzirane tvari ići dalje od uobičajenih aproksimacija, odnosno kombinirati različite metode radi dešifriranja novih kvantnih stanja.   Ovaj projekt ima za cilj iskoristiti oba, i) i ii),  pristupa pri rješavanju različitih problema od trenutnog znanstvenog interesa. To se odražava u njegova dva radna paketa i mnogim specifičnim zadatcima, na temu neuređenih magneta, bozonskih i fermionskih kvantnih sustava te klasičnih bioloških sustava. Problemima će se prići s različitih strana, u skladu sa širokom ekspertizom članova tima iz područja kritičnih ponašanja, faznih prijelaza, biofizike, jakih korelacija, neredu i lokalizaciji. Ovaj  projekt nastavlja tamo gdje je završio prethodni HrZZ-ov projekt IP-2016-06-7258, s najvišom završnom ocjenom. Pri tome, donosi nove perspektive i ideje, zajedno s novim članovima i temama.]]></summary_hr><summary_en><![CDATA[  Understanding and predicting the physical properties of materials is a tremendous challenge, owing to their complexity at the molecular/lattice/structural/electronic/spin levels. There are two main theoretical approaches to understanding such complex materials, depending on whether one is tackling the problem from a macroscopic i) or a microscopic ii) point of view.  i) As &#39;&#39;more is different&#39;&#39;, from many microscopic constituents the emergent macroscopic behavior is tough to predict. A hallmark of emergence is the universal behavior of a priori very different systems found in nature. In particular, universality has been found in various settings, ranging across a wealth of problems in statistical and solid-state physics, high-energy physics, biophysics, and econophysics. The Renormalization Group is the method of our choice to capture such behaviors, tailored to coarse-grain the microscopic details of systems to distill effective, macroscopic models.  ii) From the microscopic side, ab initio calculations are increasingly improving nowadays. However, in many materials of current scientific interest, this proves insufficient. Thus, a major concern in modern theoretical condensed matter research is to go beyond standard approximations and combine different methods to decipher new quantum states.  This project aims to investigate problems of high current interest, relying on both, i) and ii), approaches. This reflects in two work packages and many specific tasks, addressing properties of disordered magnets, boson and fermion quantum systems, as well as classical biological systems. Tasks are attacked by various means, reflecting the broad expertise of team members on critical behaviors, phase transitions, biophysics, strong correlations, disorder, and localization. The current proposal is picking up where the previous HrZZ project IP-2016-06-7258 has finished, marked by the highest final grade. It brings new perspectives and ideas, along with new members and topics.]]></summary_en></project><project>
<id>18484</id><title_hr><![CDATA[Nova uloga fosfatidilinozitol 4-kinaza u hemostazi]]></title_hr><title_en><![CDATA[New role for phosphatidylinositol 4-kinases in hemostasis]]></title_en><user_id>35</user_id><user_firstLast_name>Antonija Jurak Begonja</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-8561</code><acronim><![CDATA[PI4PLATELET]]></acronim><duration>18.12.2025 - 17.12.2028</duration><status>U tijeku</status><financ_value>200.000,00 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Fakultet biotehnologije i razvoja lijekova]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Biotechnology and Drug Development]]></institution_en><team_members_id>868238, 24298, 26105, 868166, 865075, 25359, 870441, </team_members_id><team_members_names><![CDATA[Natalie Poulter, Ana Bura, Olga Shevchuk, Sara Čabrijan, Robert Kolman, Vlatka Sotošek, Zoltan Nagy, ]]></team_members_names><keywords_hr><![CDATA[trombociti, megakariociti, fosfatidilinozitol 4-monofosfat, fosfatidilinozitol 4-kinaza, krvarenje, integrini]]></keywords_hr><keywords_en><![CDATA[platelets, megakaryocytes, phosphatidylinositol 4- monophosphate, phosphatidylinositol 4-kinase, bleeding, integrins]]></keywords_en><summary_hr><![CDATA[Trombociti zatvaraju oštećene stijenke krvnih žila kako bi spriječili krvarenje. Smanjeni broj trombocita ili njihova disfunkcija mogu dovesti do krvarenja. Povećana aktivnost trombocita, s druge strane, može dovesti do njihove prekomjerne agregacije i stvaranja tromba. Trombociti nastaju iz megakariocita u koštanoj srži kroz protrombocite u fiziološkim uvjetima ili rupturom megakariocita u uvjetima akutne potrebe za trombocitima (upale), posredovane interleukinom-1? (IL-1 ?). Aktivacija i proizvodnja trombocita zahtijevaju opsežnu reorganizaciju membrana.Fosfatidilinozitol-4-kinaze (PI4KA/B i PI4K2A/B) proizvode fosfatidilinozitol-4-monofosfat (PI4P) koji se uglavnom nalazi u Golgiju i plazma membrani. Naša preliminarna istraživanja i prethodni rezultati pokazuju da PI4KA ima važnu ulogu u aktivaciji trombocita regulirajući ?IIbß3 integrina, dok u megakariocitima doprinosi stvaranju protrombocita. Kako megakariociti sazrijevaju, PI4P mijenja lokaciju iz Golgija u plazmatsku membranu, međutim izvor i točna funkcija PI4P u različitim odjeljcima nisu poznati.U ovom projektu predlažemo primjenu farmakoloških (trombociti) i genetskih (ekspresija iz retrovirusa, CRISPR/Cas9 knockout) pristupa kako bi utvrdili koje su PI4-kinaze ključne za funkciju i stvaranje trombocita. Istražit ćemo kako je PI4KA regulirana tijekom aktivacije trombocita imunoprecipitiranjem PI4KA iz ljudskih neaktiviranih i aktiviranih trombocita te analizirati njezin interaktom masenom spektrometrijom. Osim toga, istražit ćemo utječu li uvjeti visoke potrebe za trombocitima posredovane interleukinom-1? na ekspresiju PI4K ili PI4P-efektorskih proteina, te mijenjaju li razinu PI4P u megakariocitima i tako mijenjaju brzinu proizvodnju trombocita.Ove studije će doprinijeti boljem razumijevanju osnovnih molekularnih procesa koji reguliraju homeostazu trombocita te mogu dovesti do novih terapijskih strategija.]]></summary_hr><summary_en><![CDATA[Platelets seal damaged blood vessel walls to prevent bleeding. A reduced number of platelets or their dysfunction can lead to bleeding. Increased platelet activity, on the other hand, can lead to their excessive aggregation and the formation of thrombi. Platelets are formed from megakaryocytes in the bone marrow through proplatelets under physiological conditions, or through megakaryocyte rupture in conditions of acute platelet demand (inflammation), mediated with interleukin-1? (IL-1 ?). Platelet activation and production require extensive reorganization of the membranes. Phosphatidylinositol-4-kinases (PI4KA/ B and PI4K2A/B) produce PI-4-monophosphate (PI4P) that is mainly located in the Golgi and plasma membrane. Our preliminary studies and previous data show that PI4KA plays an important role in platelet activation by regulating ?IIbß3 integrin, while in megakaryocytes it contributes to proplatelet formation. As megakaryocytes mature, PI4P changes location from the Golgi to the plasma membrane, but the source and exact function of PI4P in the different compartments are unknown.In this project, we propose to apply pharmacological (platelets) and genetic (expression from retroviruses, CRISPR/Cas9 knockout) approaches to decipher which PI4Ks are crucial for platelet function and development. We will investigate how PI4KA is regulated during platelet activation by immunoprecipitating PI4KA from human resting and activated platelets, and analyze its interactome by mass spectrometry. In addition, we will investigate whether conditions of high platelet needs mediated through interleukin-1? affect the expression of PI4Ks or PI4P-effector proteins, and change PI4P levels in megakaryocytes and thus alter the kinetics of platelet production. These studies will contribute to our understanding of the basic molecular processes underlying platelet homeostasis and may lead to new therapeutic strategies.]]></summary_en></project><project>
<id>18486</id><title_hr><![CDATA[Uloga kolektivnog odustajanja od moralnih normi u razvoju sindroma sagorijevanja u socijalnom radu]]></title_hr><title_en><![CDATA[The role of organizational moral disengagement in the development of burnout syndrome in social work]]></title_en><user_id>11224</user_id><user_firstLast_name>Darja Maslić Seršić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-8665</code><acronim><![CDATA[SOCIAL.burnout]]></acronim><duration>15.12.2025 - 14.12.2028</duration><status>U tijeku</status><financ_value>91.643,50 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Psihologija, Socijalne djelatnosti, Interdisciplinarne društvene znanosti, </scie_field_hr><scie_field_en>Psychology, Social work, Interdisciplinary social sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>26241, 870774, 6136, </team_members_id><team_members_names><![CDATA[Dinka Caha, Jasmina Tomas, Ana Slišković, ]]></team_members_names><keywords_hr><![CDATA[BAT-23, kolektivno odustajanje od moralnih normi, Model zahtjeva i resursa u radu (JD-R), sindrom sagorijevanja na poslu, socijalni rad, tihi otkaz]]></keywords_hr><keywords_en><![CDATA[BAT-23, burnout syndrome, Job Demands and rRsources model (JD-R), organizational moral disengagement, quiet quitting, social work]]></keywords_en><summary_hr><![CDATA[Sindrom sagorijevanja na poslu je središnja tema projekta, a cilj je produbiti spoznaje o prirodi i uzrocima ovog sindroma. Nacrt istraživanja se oslanja na novu definiciju sindroma sagorijevanja te dvije utjecajne psihologijske teorije: Teoriju zahtjeva i resursa na poslu koja objašnjava uzroke i posljedice radne dobrobiti i Teoriju moralnog djelovanja koja opisuje psihosocijalne mehanizme deaktivacije moralne samoregulacije. Središnji koncept je kolektivno odustajanje od moralnih normi (OrgMO), mehanizam koji pojašnjava kako sama organizacija može poticati neetično radno ponašanje zaposlenika. Smatramo da doživljaj OrgMO ima ishode i u drugim oblicima neučinkovitog radnog ponašanja, a da u podlozi ove veze leži razvoj sindroma sagorijevanja. Polazna ideja je da doživljaj kolektivnog odustajanja od moralnih normi iscrpljuje pojedinca jer povećava zahtjeve posla (prvenstveno konflikt unutar uloge, nejasnoću uloge i emocionalne zahtjeve posla). Rezultat je veza između OrgMO i pojave sindroma sagorijevanja na poslu. Time projekt doprinosi razvoju fundamentalnih spoznaja u području psihologije profesionalnog zdravlja, a novost je integracija Teorije moralnog djelovanja i Modela zahtjeva i resursa u radu kako bi dublje razumjeli učinak organizacijskog konteksta na doživljaj intenziteta zahtjeva posla. Projekt nadilazi spoznajna ograničenja istraživanja koja se temelje na intraindividualnoj metodologiji i razvoj sindroma sagorijevanja objašnjavaju isključivo individualnom percepcijom zahtjeva posla. Istraživački nacrt se temelji na longitudinalnoj panel studiji u tri vremenske točke i višerazinskoj analizi podataka, a prikupljeni podaci bit će analizirani najsuvremenijim statističkim postupcima na latentnim modelima prikupljenih podataka. Primijenjena svrha projekta leži u istraživanju uloge kolektivnog odustajanja od moralnih normi u razvoju sindroma sagorijevanja u socijalnom radu i njegovim posljedicama na kvalitetu socijalnih usluga.]]></summary_hr><summary_en><![CDATA[Burnout syndrome is central to the proposed project, which aims to deepen the understanding of its nature and underlying causes. The research design incorporates a new definition of burnout syndrome and draws upon two influential psychological theories: the Job Demands-Resources (JD-R) Theory, which explains the causes and consequences of occupational well-being, and the Theory of Moral Disengagement, which describes the psychosocial mechanisms underlying the deactivation of moral self-regulation. Additionally, this research framework integrates organizational or collective moral disengagement (OrgMD)—a mechanism that explains how organizational structures and practices can foster unethical employee behavior. The project posits that the experience of OrgMD has significant consequences for other forms of ineffective work behavior, with burnout syndrome serving as a key underlying factor in this relationship. The central hypothesis is that collective moral disengagement depletes individuals by increasing job demands, particularly role conflict, role ambiguity, and emotional job demands.  Thus, a link is proposed between collective moral disengagement and the onset of workplace burnout. By integrating the Theory of Moral Disengagement and the JD-R Model, this research provides a novel approach to understanding how organizational contexts influence employees&#39; perceptions of job demands, thus addressing the limitations of previous research that has focused on intra-individual factors. Using a longitudinal panel study conducted at three time points and a multilevel data analysis (intra-individual and organizational levels), the research will employ latent variable modeling to assess the relationships the relationships between organizational phenomena and burnout. An applied purpose of this project is to investigate the role of collective moral disengagement in developing burnout among social service professionals and its consequences for the quality of social services.]]></summary_en></project><project>
<id>18492</id><title_hr><![CDATA[Razvoj i karakterizacija širokopojasnih induktivnih osjetila bliskog magnetskog polja ]]></title_hr><title_en><![CDATA[Development and Characterization of Wideband Inductive Sensors for Near Magnetic Field ]]></title_en><user_id>328</user_id><user_firstLast_name>Martin Dadić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-5004</code><acronim><![CDATA[ŠIOMAG]]></acronim><duration>05.12.2025 - 04.12.2028</duration><status>U tijeku</status><financ_value>156.149,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>19352, 3683, 142, 865800, 3230, 868204, 6931, 865060, 870375, 5559, </team_members_id><team_members_names><![CDATA[Krešimir Malarić, Josipa Pina Milišić, Marko Jurcevic, Luka Ferković, Goran Petrović, Ivan Leniček, Danijel Šestan, Mario Filipašić, Ivan Matas, Lovorka Grgec Bermanec, ]]></team_members_names><keywords_hr><![CDATA[blisko polje, magnetsko polje, širokopojasna osjetila, elektromagnetska kompatibilnost, numeričko modeliranje, umjeravanje]]></keywords_hr><keywords_en><![CDATA[near field, magnetic field, wideband sensors, electromagnetic compatibility, numerical modeling, calibration]]></keywords_en><summary_hr><![CDATA[Suvremeni trend povećanja kompleksnosti električnih i elektroničkih uređaja ima za posljedicu sve veći broj izvora elektromagnetskog zračenja u okolišu. Osjetila bliskog magnetskog polja daju značajan uvid u izvore i puteve širenja vođenih i zračenih smetnji, te pridonose ispravnom dizajnu proizvoda . Metodologija istraživanja fokusirat će se na tri radne cjeline: 1) Razvoj osjetila bliskog magnetskog polja, pri čemu se teži zadovoljenju uvjeta širokopojasnog (nerezonantnog) rada, ali uz podjelu na više širih frekvencijskih pojaseva. 2) Postupke računalnog modeliranja i proračuna osjetila i sustava umjeravanja. 3) Razvoj postupaka umjeravanja. Ciljevi projekta su: Razvoj nelinearnih modela magnetskih materijala prikladnih za primjenu u analitičkim i numeričkim proračunima kao i primjena modela u numeričkom proračunu osjetila uz analizu konvergencije. Razvoj osjetila za mjerenje bliskog magnetskog polja u tehnologiji tiskanih veza i za frekvencije do 10 MHz s feromagnetskom jezgrom i bez nje. Unaprjeđenje sustava umjeravanja indukcijskih osjetila magnetskog polja za frekvencije do 100 kHz, uz karakterizaciju i razvoj potrebnih strujnih pretvornika. Razvoj mjernog sustava za određivanje značajki materijala u frekvencijskom području do 9 GHz. Razvoj diferencijalnih indukcijskih osjetila s integriranim pretpojačalom i predviđenim frekvencijskim pojasom do 9 GHz uz sustav oklapanja. Razvoj metode umjeravanja razvijenih osjetila u GTEM komori uz validaciju rezultata. Razvoj osjetila za određivanje površinske otpornosti izolacijskog materijala. Primjena razvijenih sondi i sustava za umjeravanje kao izvora magnetskog polja u ispitivanju elektromagnetske kompatibilnosti.]]></summary_hr><summary_en><![CDATA[The modern trend of increasing the complexity of electrical and electronic devices results in an increasing number of sources of electromagnetic radiation in the environment. Sensors of the near magnetic field provide significant insight into the sources and propagation paths of conducted and radiated disturbances, and contribute to the correct design of products. The research methodology will focus on three work packages: 1) Development of near magnetic field sensors, where the aim is to satisfy the conditions of broadband (non-resonant) operation, but with a division into several frequency bands. 2) Procedures of computer modeling and calculation of sensors and calibration systems. 3) Development of calibration procedures. Project goals are: Development of nonlinear models of magnetic materials suitable for use in analytical and numerical calculations, as well as the application of these models in the numerical calculation of sensors, including convergence analysis. Improvement of the calibration methods of magnetic field induction sensors for frequencies up to 100 kHz, along with the characterization and development of the accompanied current transducers. Development of a measuring system of material properties in the frequency range up to 9 GHz. Development of differential induction sensors with integrated preamplifiers designed for the operation in the frequency range up to 9 GHz, including a shielding system. Development of a calibration method using the GTEM cell with validation of the results. Development of a sensor for determining the surface resistance of insulating materials. Application of the developed probes and calibration systems as a magnetic field source in electromagnetic compatibility testing.]]></summary_en></project><project>
<id>18493</id><title_hr><![CDATA[DRUMS - Deep Tech & Robotics for Human-Centred Manufacturing ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4210</user_id><user_firstLast_name>Marija Seder</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-1445</code><acronim><![CDATA[]]></acronim><duration>01.12.2025 - 30.11.2031</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>872916</team_members_id><team_members_names><![CDATA[ Doktorand: Jelena Rogina ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>18501</id><title_hr><![CDATA[Molekularna epidemiologija multiplo-rezistentnih uropatogena i njihov potencijal širenja u zajednici]]></title_hr><title_en><![CDATA[Molecular epidemiology of multidrug-resistant uropathogens and their dissemination potential in the community]]></title_en><user_id>12641</user_id><user_firstLast_name>Jasmina Vraneš</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-6757</code><acronim><![CDATA[MDRdissPotent]]></acronim><duration>15.12.2025 - 14.12.2028</duration><status>U tijeku</status><financ_value>199.998,00 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, Kliničke medicinske znanosti, Javno zdravstvo i zdravstvena zaštita, </scie_field_hr><scie_field_en>Basic Medical Sciences, Clinical sciences, Public health and health services, </scie_field_en><institution_hr><![CDATA[Nastavni zavod za javno zdravstvo Dr. Andrija Štampar, Zagreb]]></institution_hr><institution_en><![CDATA[Andrija Stampar Teaching Institute of Public Health, Zagreb]]></institution_en><team_members_id>1527, 19544, 12444, 19462, 870443, 870428, 870544, 870437, 870502, </team_members_id><team_members_names><![CDATA[Branka  Bedenić, Ivan Barisic, Gernot Zarfel, Tatjana Marijan, Vladimira Tičić, Sandra Šuto, Maja Anušić, Tajana Balaban, Lucija Vlahek, ]]></team_members_names><keywords_hr><![CDATA[Bakterijska rezistencija, bakterijska virulencija, potencijal klonalnog širenja, infekcije mokraćnog sustava, infekcije stečene u zajednici]]></keywords_hr><keywords_en><![CDATA[Bacterial resistance, bacterial virulence, clonal dissemination potential, urinary tract infections, community-acquired infections]]></keywords_en><summary_hr><![CDATA[Multiplo-rezistentne (MDR) i ekstenzivno-rezistentne (XDR) bakterije predstavljaju globalnu prijetnju, a njihove klonalne linije od nedavno se šire u izvanbolničkoj populaciji, a ne više samo u bolnicama i domovima za starije. Među najčešće detektiranim uropatogenima u pacijenata koji su akvirirali uroinfekciju u zajednici detektirali smo klonalnu liniju O25 ST131 fluorokinolon-rezistentne bakterije Escherichia coli, te u postpandemijskom razdoblju porast učestalosti detekcije enterobakterija koje pored beta-laktamaza proširenog spektra produciraju i karbapenemaze.  Zabrinjava pojava nedavno detektiranih metalo beta-aktamaza-producirajućih sojeva bakterije Proteus mirabilis u izvanbolničkoj populaciji u Zagrebu, te detekcija hipervirulentnih izolata MDR sojeva K. pneumoniae u europskim zemljama. MDR i XDR izolati uropatogena predstavljaju veliki terapijski problem, pa je neophodna njihova karakterizacija i procjena potencijala njihovog širenja. Sposobnost klonalnog širenja ovisi o bakterijskim virulentnim svojstvima i bakterijskim metaboličkim svojstvima, koji uvjetuju bakterijsku sposobnost umnažanja i izazivanja infekcije u inače zdravih ljudi. Stoga je cilj predloženog istraživanja molekularna karakterizacija MDR izolata E. coli, K. pneumoniae i P. mirabilis prikupljenih iz mokraće pacijenata s infekcijom mokraćnog sustava akviriranom u zajednici, a pored mehanizama rezistencije istraživat će se također virulentne i metaboličke značajki ovih bakterija, kako bi se prosudio njihov potencijal širenja. Upotrijebit će se standardni fenotipski testovi te molekularne metode za karakterizaciju rezistoma, viruloma i metaboloma prikupljenih MDR izolata. Predloženo istraživanje značajno je zbog pravovremene detekcije pojedinih hipervirulentnih klonalnih linija MDR bakterija te uvođenja mjera prevencije njihovog širenja u zajednici.  ]]></summary_hr><summary_en><![CDATA[Multidrug-resistant (MDR) and extensively drug-resistant (XDR) bacteria represent a global threat, and their clonal lines have recently been spreading in the outpatient population, and no longer only in hospitals and nursing homes. Among the most frequently detected uropathogens in patients who acquired uroinfection in the community, we detected the clonal line O25 ST131 of the fluoroquinolone-resistant bacterium Escherichia coli, and in the post-pandemic period, an increase in the frequency of detection of enterobacteria that, in addition to extended-spectrum beta-lactamases, also produce carbapenemases. The appearance of recently detected metallo beta-actamase-producing strains of Proteus mirabilis in outpatient population In Zagreb, and the detection of hypervirulent isolates of MDR strains of K. pneumoniae in European countries, is of great concern. MDR and XDR isolates of uropathogens represent a major therapeutic problem, so their characterization and evaluation of the potential of their spread is necessary. The ability of clonal spread depends on bacterial virulence properties and bacterial metabolic properties, which determine the bacterial ability to multiply and cause infection in otherwise healthy people. Therefore, the aim of the proposed research is the molecular characterization of MDR isolates of E. coli, K. pneumoniae and P. mirabilis collected from the urine of patients with community-acquired urinary tract infections, and in addition to resistance mechanisms, the virulence and metabolic features of these bacteria will also be investigated, in order to predict their spreading potential. Standard phenotypic tests and molecular methods will be used to characterize the resistome, virulome and metabolome of the collected MDR isolates. The proposed research is significant due to the timely detection of certain hypervirulent clonal lines of MDR bacteria and the introduction of measures to prevent their spread in the community.]]></summary_en></project><project>
<id>18507</id><title_hr><![CDATA[Modernisation of Land and Urban Management in Southern Mediterranean (MLUMSE)]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1319</user_id><user_firstLast_name>Ana Mrđa</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-7872</code><acronim><![CDATA[]]></acronim><duration>01.02.2026 - 31.01.2032</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Arhitektura i urbanizam, </scie_field_hr><scie_field_en>Architecture and Urban Environment, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Arhitektonski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Architecture]]></institution_en><team_members_id>873048</team_members_id><team_members_names><![CDATA[ Doktorand: Hana Dašić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>18509</id><title_hr><![CDATA[Imunosuberzivne strategije citomegalovirusa: Utjecaj na MHC I i citotoksične limfocite]]></title_hr><title_en><![CDATA[Immunoevasion strategies of cytomegalovirus: Modulation of MHC I and cytotoxic lymphocytes]]></title_en><user_id>17754</user_id><user_firstLast_name>Jelena Železnjak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2025-02</proposal_call><code>UIP-2025-02-2353</code><acronim><![CDATA[MAT-NES]]></acronim><duration>01.04.2026 - 31.03.2031</duration><status>U tijeku</status><financ_value>299.420,00 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Medicine]]></institution_en><team_members_id>5204, 22696, 865893, </team_members_id><team_members_names><![CDATA[Paola Kučan Brlić, Tina Ružić, Magdalena  Medved, ]]></team_members_names><keywords_hr><![CDATA[Citomegalovirus, molekule MHC I, peptidom, citotoksični limfociti T, stečena imunost]]></keywords_hr><keywords_en><![CDATA[Cytomegalovirus, MHC I molecules, peptidome, cytotoxic lymphocytes, adaptive immunity]]></keywords_en><summary_hr><![CDATA[Citomegalovirus (CMV) je široko rasprostranjen ß-herpesvirus sposoban za doživotnu perzistenciju u domaćinu. Ključni mehanizam kojim CMV izbjegava imunološki sustav je manipulacija molekula glavnog kompleksa tkivne snošljivosti I (MHC I), čime utječe na odgovor citotoksičnih limfocita T (CTL) i stanica prirođene imunosti (NK). Među virusnim proteinima uključenima u ovaj proces, MATp1, kodiran s najviše izraženog transkripta mišjeg CMV-a (MCMV), zajedno s proteinom m04, modulira izražaj MHC I, osiguravajući učinkovitu inhibiciju stanica NK putem inhibicijskih receptora Ly49. Međutim, naši preliminarni podaci ukazuju da CMV koristi MATp1, ne samo za regulaciju odgovora stanica NK, već i za modulaciju antigenske prezentacije, potencijalno smanjujući kvalitetu prezentiranih peptida. Sukladno tome, in vivo model infekcije divljim tipom MCMV-a pokazuje slabiji CD8 T-stanični odgovor u usporedbi s virusom kojemu nedostaje MATp1.Stoga je cilj ovog istraživanja razjasniti mehanizme djelovanja MATp1 na molekule MHC i istražiti kako kvaliteta peptida utječe na stečeni imunološki odgovor. Budući da se CMV razmatra kao platforma za razvoj cjepiva, bolje razumijevanje njegove interakcije s imunološkim sustavom moglo bi unaprijediti antivirusne strategije. To je osobito važno za HCMV-baziranu adoptivnu T-staničnu terapiju (ACT), koja primjenjuje virus-specifične CTL-ove u kontroli infekcije kod imunokompromitiranih pacijenata. Poboljšana saznanja o tomu kako CMV modulira MHC I i antigensku prezentaciju omogućila bi preciznije dizajniranje terapijskih protokola i optimizaciju CD8 T-staničnog odgovora.]]></summary_hr><summary_en><![CDATA[Cytomegalovirus (CMV) is a widespread ß-herpesvirus that can persist in its host for a lifetime. One of its main strategies to evade immune response involves modulation of major histocompatibility complex class I (MHC I) molecules, thereby affecting cytotoxic T lymphocytes (CTLs) and innate immune cells (NK cells) responses. Among the viral proteins involved in this process, MATp1, encoded by the most highly expressed transcript of murine CMV (MCMV), partners with m04 protein, to modulate MHC I expression, ensuring effective inhibition of NK cells via inhibitory Ly49 receptors. However, our preliminary data indicate that CMV utilizes MATp1 not only to regulate NK cell responses, but also to modulate antigen presentation, potentially reducing the quality of the presented peptides on MHC I molecules. Accordingly, in vivo infection model with the wild-type MCMV exhibits a weaker CD8 T-cell response compared to a MCMV lacking MATp1, suggesting its role in immune evasion.The aim of this study is to elucidate the mechanisms of MATp1 modulation of MHC molecules and to investigate how peptide quality affects the adaptive immune response. Since CMV is being explored as a platform for vaccine development, unraveling its immune evasion tactics could advance antiviral strategies. This is particularly important for HCMV-based adoptive T-cell therapy (ACT), which utilizes virus-specific CTLs to control infection in immunocompromised patients. Improved understanding of how CMV manipulates MHC I and antigen presentation may lead to more precise therapeutic protocols and optimized CD8 T-cell responses.]]></summary_en></project><project>
<id>18510</id><title_hr><![CDATA[Metafilozofija]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6140</user_id><user_firstLast_name>Boran Berčić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-7900</code><acronim><![CDATA[MetPhil]]></acronim><duration>16.12.2025 - 15.12.2031</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filozofija, </scie_field_hr><scie_field_en>Philosophy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Filozofski fakultet u Rijeci]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>873001</team_members_id><team_members_names><![CDATA[ Doktorand: Matija Rajter ]]></team_members_names><keywords_hr><![CDATA[Filozofija, metafilozofija, metodologija, pojmovna analiza, zaključak na najbolje objašnjenje, refleksija, opravdanje]]></keywords_hr><keywords_en><![CDATA[Philosophy, metaphilosophy, methodology, conceptual analysis, inference to the best explanation, reflection, justification]]></keywords_en><summary_hr><![CDATA[U okviru ovog projekta nastojat ćemo odgovoriti na pitanje Što je filozofija?Raspravit ćemo najčešća gledišta i pokušati utvrditi jesu li održiva. To su: (1) Filozofska pitanja su ona za koja josˇ nije utvrđena standardna metodologija rjesˇavanja. (2) Filozofija je znanost, razlika je u stupnju općenitosti ali ne u vrsti. (3) Sinopticˇko gledište prema kojem je posao filozofije stvaranje sveobuhvatne slike svijeta. (4) Filozofija je njena povijest. (5) Filozofija je pojmovna analiza. (6) Filozofija je refleksija o načinu na koji opravdavamo svoja vjerovanja i djelovanja.Analizirat ćemo poznate i/ili tipične filozofske argumente i nastojati pokazati kojem od ovih shvaćanja odgovaraju. Na primjer, pitanje je kako shvatiti poznati Platonov One Over Many argument za postojanje univerzalija. Je li on izložen kao zaključak na najbolje objašnjenje (gledište 2), kao pojmovno pojašnjenje (gledište 5), ili kao opravdanje vjerovanja (opcija 6)? Ovakvu analizu primjenit ćemo i na druge poznate i tipične filozofske argumente: Mooreov test izolacije za utvrđivanje intrinzičnog dobra, McTaggartov argument da vrijeme nije realno, Mackiev argument from queerness da moralna svojstva ne postoje, Benacerrafov argument protiv platonizma u matematici, Blackov misaoni eksperiment s dvije kugle kojim nastoji oboriti Leibnizov zakon, itd.Iako je većina suvremenih autora sklona opciji (5), fokus će biti na opcijama (2) i (6) jer smatramo da one najviše obećavaju. Jasno, pitanje je što će pokazati detaljna analiza i pitanje je postoji li uopće jedinstveni odgovor na pitanje Što je filozofija?]]></summary_hr><summary_en><![CDATA[In this project we will try to answer the question What is Philosophy? We will discuss the most common views and try to estimate whether they are tenable. (1) Philosophical questions are those that do not yet have standard methodology. (2) Philosophy is science, the difference between the two is a matter of degree, not of kind. (3) Synoptic view - the goal of philosophy is to create an all-encompassing picture of the world. (4) Philosophy is its history. (5) Philosophy is conceptual analysis. (6) Philosophy is a reflection about the way in which we justify our beliefs and actions.We will analyze well known and typical philosophical arguments and try to show to which understanding of philosophy they fit best. For example, how to understand the well-known Plato&#39;s One over Many argument for the existence of the universals? Is it put forward as an inference to the best explanation (view 2), as a conceptual clarification (view 5), or as a justification of belief (view 6)? This kind of analysis we will apply to other well-known philosophical arguments: Moore&#39;s test of isolation for determining whether a value is intrinsic, McTaggart&#39;s argument that time is not real, Mackie&#39;s argument from queerness against the existence of moral properties, Benacerraf&#39;s argument against Platonism in mathematics, Black&#39;s thought experiment with two balls aimed at refuting Leibniz&#39;s Law, etc.Although most contemporary authors favor the view of Philosophy as conceptual analysis (5), the focus will be on the views (2) and (6) because we believe that they are the most promising ones. Of course, the question is what will the detailed analysis show, and whether there is a single answer to the question What is Philosophy?]]></summary_en></project><project>
<id>18514</id><title_hr><![CDATA[Health Outcomes from Raised Urban Settings&#39;&#39; - akronim: HORUS, (broj ugovora: 101136516)]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6539</user_id><user_firstLast_name>Vanja Vasiljev</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-5698</code><acronim><![CDATA[]]></acronim><duration>26.01.2026 - 25.01.2032</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Javno zdravstvo i zdravstvena zaštita, </scie_field_hr><scie_field_en>Public health and health services, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Medicine]]></institution_en><team_members_id>873097</team_members_id><team_members_names><![CDATA[ Doktorand: Dalila Sadiku ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>18515</id><title_hr><![CDATA[Baza podataka Sunčevih pjega]]></title_hr><title_en><![CDATA[Sunspot database]]></title_en><user_id>6028</user_id><user_firstLast_name>Davor Sudar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-1659</code><acronim><![CDATA[SSDB]]></acronim><duration>21.01.2026 - 20.01.2029</duration><status>U tijeku</status><financ_value>122.525,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Geodetski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Geodesy]]></institution_en><team_members_id>6078, 4326, </team_members_id><team_members_names><![CDATA[Roman Brajša, Domagoj Ruždjak, ]]></team_members_names><keywords_hr><![CDATA[fizika Sunca, Sunčeve pjege, Sunčeva aktivnost, rotacija Sunca, Sunčev dinamo]]></keywords_hr><keywords_en><![CDATA[solar physics, sunspots, solar activity, solar rotation, solar dynamo]]></keywords_en><summary_hr><![CDATA[Sunčeve pjege su najprepoznatljivije značajke na površini Sunca i promatraju se te bilježe još od ranog 17. stoljeća. Budući da su neke zvjezdarnice koje su pratile i bilježile karakteristike sunčevih pjega prestale s radom, važno je stvoriti bazu podataka o sunčevim pjegama koristeći moderne podatke. Planiramo za tu svrhu koristiti promatranja Solar Dynamics Observatory (SDO). Baza podataka bit će javno dostupna po završetku projekta. Kako bismo to ostvarili, razviti ćemo metodu dovoljno fleksibilnu za analizu promatranja Sunčevih pjega iz različitih opservatorija. Najvažniji aspekt ovog prijedloga je znanstvena upotreba baze podataka Sunčevih pjega. Planiramo istražiti solarnu aktivnost, nagib grupa Sunčevih pjega, rotaciju Sunca, meridionalno gibanje, Reynoldsov stres i asimetriju između sjeverne i južne hemisfere.]]></summary_hr><summary_en><![CDATA[Sunspots are the most recognizable features on the solar surface and have been observed and cataloged since the early 17th century. Since some observatories that tracked and recorded sunspot characteristics have ceased operations, it is important to create a sunspot database using modern data. We plan to use observations from the Solar Dynamics Observatory (SDO) for this task. The database will be made publicly available at the end of the project. To achieve this, we will develop a method flexible enough to analyze sunspot observations from multiple observatories. The most important aspect of this proposal is the scientific exploitation of the sunspot database. We plan to investigate solar activity, the tilt of sunspot groups, solar rotation, meridional motion, Reynolds stress, and North/South asymmetry.]]></summary_en></project><project>
<id>18516</id><title_hr><![CDATA[Srednjovjekovni ruralni krajolik kontinentalne Hrvatske]]></title_hr><title_en><![CDATA[Medieval Rural Space of Continental Croatia]]></title_en><user_id>29659</user_id><user_firstLast_name>Tomislav Matić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-4984</code><acronim><![CDATA[MERUS]]></acronim><duration>08.12.2025 - 07.12.2028</duration><status>U tijeku</status><financ_value>125.175,00 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Povijest, Filologija, Arheologija, Interdisciplinarne humanističke znanosti, </scie_field_hr><scie_field_en>History, Philology, Archeology, Interdisciplinary humanities, </scie_field_en><institution_hr><![CDATA[Hrvatski institut za povijest]]></institution_hr><institution_en><![CDATA[Croatian Institute of History]]></institution_en><team_members_id>633, 1311, 5332, 870920, 28952, 870926, 19794, </team_members_id><team_members_names><![CDATA[Marija Karbić, Robert Skenderović, Branimir Brgles, Silvija Pisk, Hrvoje Kekez, Maja Bunčić, Krešimir Regan, ]]></team_members_names><keywords_hr><![CDATA[ruralna povijest, kontinentalna Hrvatska, srednji vijek, arhivska istraživanja, terenska istraživanja]]></keywords_hr><keywords_en><![CDATA[rural history, continental Croatia, Middle Ages, archival research, field studies]]></keywords_en><summary_hr><![CDATA[U sklopu ovog projekta proučavalo bi se ruralnu povijest kontinentalne Hrvatske u srednjem vijeku vršenjem arhivskih istraživanja i istraživanjima lokaliteta. Njime bi se ruralnu povijest, koja do sada nije bila predmet bavljenja hrvatske znanosti, dovelo u fokus znanstvenog istraživanja, te potaknulo interes za prošlos hrvatskog ruralnog prostora, koji je do sada bio vrlo slabo istražen. Pri tome bi se koristile suvremene metode ruralne povijesti i poticalo bi se članove projekta na razmjenu iskustva sa stranim stručnjacima. Srednjovjekovni ruralni prostor kontinentalne Hrvatske bit će sagledan i u cjelini i analizom pojedinačnih slučajeva. S obzirom na prirodu dostupnih izvora, istraživanja će se fokusirati na odnos čovjeka i prirode, djelatnosti stanovništva sela u srednjem vijeku, raspored seoskih naselja itd. Multidisciplinarni pristup bit će nužan. Glavni cilj projekta bio bi staviti povijest hrvatskog sela u fokus istraživanja, odnosno dovesti ga s položaja predmeta od perifernog interesa, koji služi tek kao dopuna drugim segmentima povijesti, u središte povijesnog rada. Znanstvenim studijama koje bi iz ovog rada proizašle postavile bi temelje za šire istraživanje hrvatskog sela u prošlosti. Rezultati projekta bili bi predstavljeni znanstvenoj i široj javnosti u obliku znanstvenih studija i diseminacijskim aktivnostima, a rezultate svojih istraživanja članovi projekta ponudili bi lokalnim zajednicama u obliku javnih predavanja, izložbi ili podataka za ostvarivanje njihova napretka. Mnoge lokalne zajednice nisu svjesne da njihova povijest seže sve do razvijenog srednjeg vijeka, ili da se na prostoru njihove općine nalazila crkva, samostan ili fortifikacija. Smatramo da bi ovaj projekt mogao privući interes šire javnosti i biti na korist razvoju hrvatskog sela.]]></summary_hr><summary_en><![CDATA[This project would study the rural history of cntinental Croatia in the Middle Ages by conducting archival research and field studies. It would aim to bring rural history, which until now has not drawn the attention of Croatian scientists, into the focus of scientific research, and spark an interest in the past of the Croatian rural space, which has until now not been extensively studied. Up-to-date methods of rural history would be applied and project members would be encouraged to exchange experiences with foreign experts. The medieval rural space of continental Croatia will be considered both as a whole and through analyses of singular cases. Considering the nature of available sources, the research will focus on the relation between man and nature, activities of the rural populace in the Middle Ages, the distribution of rural settlements, etc. A multidisciplinary approach will be necessary. The main goal of this project is to place the history of the Croatian countryside in the focus of historical research, or rather to elevate it from the position on the periphery of scientific interest, where it serves only to complement other segments of historiography. Scientific studies which would result from these efforts could lay the foundations for further research of the history of the Croatian countryside. The results of this project would be presented to the scientific and broader public in the form of scientific studies and dissemination activities,  and project members would offer the local communities the results of their research in the form of public lectures, exhibitions or information that could help their development. Many local communities are not aware that their history reaches as far back as the High Middle Ages, or that on the territory of their county there used to be a church, a monastery or a fortification. We believe that this project could attract the interest of the broader public and contribute to the development of the Croatian countryside.]]></summary_en></project><project>
<id>18517</id><title_hr><![CDATA[Ugađanje topološke materije naprezanjem i magnetizmom]]></title_hr><title_en><![CDATA[Tuning topological matter by strain and magnetism ]]></title_en><user_id>866157</user_id><user_firstLast_name>Ana Akrap</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-1189</code><acronim><![CDATA[TuTop]]></acronim><duration>31.12.2025 - 30.12.2028</duration><status>U tijeku</status><financ_value>199.996,50 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>869952, 866120, </team_members_id><team_members_names><![CDATA[Jakov Budić, Petar Sačer, ]]></team_members_names><keywords_hr><![CDATA[topološki materijali, infracrvena spektroskopija, magnetooptička spektroskopija, magnetsko polje, magnetski poluvodiči]]></keywords_hr><keywords_en><![CDATA[topological materials, infrared spectroscopy, magneto-optical spectroscopy, high magnetic field, magnetic semiconductors]]></keywords_en><summary_hr><![CDATA[Topološki materijali su potencijalno važni za elektroničke i optoelektroničke primjene, ali su jednako interesantni i s fundamentalnog gledišta. Imaju nova osnovna stanja, kao što su površinska stanja topološkog izolatora ili Weyl fermioni. Ključan aspekt je njihova niska energetska ljestvica. Ovi materijali često imaju malen ili nulti procjep među vrpcama, a na njihove vrpčne strukture mogu uvelike utjecati male perturbacije. To može dovesti do novih funkcionalnosti – moguće je modificirati elektronička svojstva na zahtjev, uključivanjem ili isključivanjem male perturbacije.U ovom projektu koristit ćemo mehaničku deformaciju (naprezanje) i unutarnji magnetizam kao dvije takve perturbacije kako bismo pogurnuli topološke materijale u nova osnovna stanja. Uniaksijalno naprezanje i unutarnji magnetizam idealno su prilagođeni za podešavanje svojstava topoloških materijala, iskorištavajući prednosti njihovih malih energetskih skala, kako bi stvorili nova osnovna stanja.Glavno pitanje kojim će se baviti ovaj projekt je: Kako možemo koristiti naprezanje i magnetizam kao topološke sklopke? Jedna je hipoteza da jednoosno naprezanje može potpuno promijeniti topološka svojstva odabranih materijala. Druga hipoteza je da postoje netrivijalni potpisi magnetizma u topološkim materijalima - kao što su antiferomagnetske rezonancije ili promjene u disperziji vrpca - kojima se može pristupiti i podesiti vanjskim magnetskim poljem. Trenutno nedostaju spektroskopski potpisi bilo kojeg od ta dva učinka.Glavna eksperimentalna metoda bit će infracrvena spektroskopija, idealno prikladna za spektroskopsko razumijevanje niskoenergetskih fenomena. Jedan ishod ovog projekta bit će spajanje naprezanja i magnetooptičkih mjerenja. U magnetskim topološkim materijalima, uvest ćemo na kontroliran način snažan lokalni magnetizam u kandidate za topološke materijale, a korištenjem Landauove spektroskopije visoke razlučivosti tražit ćemo snažne promjene u njihovim topološkim osnovnim stanjima.]]></summary_hr><summary_en><![CDATA[Topological materials are promising for electronic and optoelectronic applications, but from a more fundamental perspective, they are equally exciting. They have new ground states, for example surface states of a topological insulator, or Weyl fermions, which otherwise cannot be found in classical metals or semiconductors.  One key aspect is their low energy scales. These materials often have small or zero band gaps, and their band structures can be greatly influenced by small perturbations. This can lead to new functionalities – one can modify electronic properties on demand, by switching a small perturbation on or off. In this project we will use strain and internal magnetism as two such perturbations to push topological materials into new ground states. Uniaxial strain and internal magnetism are ideally suited to tune the properties of topological materials, taking advantage of their appropriately small energy scales, and create novel ground states.The main scientific question that this project will address is: How can we use strain and magnetism as topological switches? One hypothesis is that uniaxial strain can completely alter select materials’ topological properties. Another hypothesis is that there are nontrivial signatures of magnetism in topological materials—like antiferromagnetic resonances, or changes in underlying band dispersion—which can be accessed and tuned by an external magnetic field. Spectroscopic signatures of either of the two effects are currently lacking. The main experimental method will be infrared spectroscopy, ideally suited for a spectroscopic understanding of low-energy phenomena. One outcome of this project will be to couple strain and magneto-optical measurements. In magnetic topological materials, we will introduce in a controlled way strong local magnetism into topological material candidates, and using high-resolution Landau level spectroscopy we will look for strong changes in their topological ground states. ]]></summary_en></project><project>
<id>18519</id><title_hr><![CDATA[Oksidativni potencijal lebdećih čestica i organski markeri onečišćenja zraka ]]></title_hr><title_en><![CDATA[Oxidative Potential and Airborne Organic Tracers ]]></title_en><user_id>23380</user_id><user_firstLast_name>Ranka Godec</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-1844</code><acronim><![CDATA[OxAirTracers]]></acronim><duration>12.01.2026 - 11.02.2029</duration><status>U tijeku</status><financ_value>188.500,00 eur</financ_value><scie_area_hr>Prirodne znanosti, Biomedicina i zdravstvo, </scie_area_hr><scie_area_en>Natural sciences, Biomedicine and health sciences, </scie_area_en><scie_field_hr>Kemija, Javno zdravstvo i zdravstvena zaštita, </scie_field_hr><scie_field_en>Chemistry, Public health and health services, </scie_field_en><institution_hr><![CDATA[Institut za medicinska istraživanja i medicinu rada]]></institution_hr><institution_en><![CDATA[Institute for Medical Research and Occupational Health]]></institution_en><team_members_id>4131, 4294, 25961, 1224, 868434, 870907, 4603, 870939, 870906, 2649, </team_members_id><team_members_names><![CDATA[Suzana Sopčić, Ivan Bešlić, Iva Smoljo, Gordana Mendaš Starčević, Valentina Gluščić, Helena Prskalo, Milan Milošević, Ivona Mikić, Marija Jelena Lovrić Štefiček, Blanka Tariba Lovaković, ]]></team_members_names><keywords_hr><![CDATA[oksidativni potencijal, organski markeri, kvaliteta zraka, zdravstveni učinci, PM2,5]]></keywords_hr><keywords_en><![CDATA[oxidative potential, organic tracers, air quality, health effects, PM2.5]]></keywords_en><summary_hr><![CDATA[Onečišćenje zraka lebdećim česticama predstavlja značajan okolišni i zdravstveni problem s dokazanim utjecajem na respiratorne i kardiovaskularne bolesti. Iako se njihova štetnost tradicionalno procjenjuje na temelju ukupne mase, sve je jasnije da kemijski sastav lebdećih čestica igra ključnu ulogu u njihovoj toksičnosti. Posebno su važni organski markeri, poput policikličkih aromatskih ugljikovodika, polikloriranih bifenila, elementnog i crnog ugljika, levoglukozana i organskih kiselina, koji mogu utjecati na oksidativni potencijal (OP) lebdećih čestica – pokazatelj njihove sposobnosti da induciraju oksidativni stres u ljudskom organizmu.Dosadašnja istraživanja u Europi i svijetu ukazuju na potrebu za boljim razumijevanjem veze između kemijskog sastava PM2,5 i njihovog oksidativnog potencijala, no u Hrvatskoj i regiji takvi podaci još uvijek nisu sustavno prikupljeni. Nedostatak informacija o prisutnosti organskih markera, njihovoj sezonskoj i prostornoj varijabilnosti te povezanosti s oksidativnim stresom predstavlja znanstvenu prazninu koju ovaj projekt nastoji popuniti.Projekt će se fokusirati na identifikaciju i kvantifikaciju organskih markera u PM2,5, određivanje njihovog oksidativnog potencijala te istraživanje njihovog potencijalnog utjecaja na zdravlje ljudi. Kroz sezonska mjerenja i laboratorijske analize, projekt će osigurati nove spoznaje o toksičnim komponentama lebdećih čestica, što će omogućiti unapređenje monitoringa kvalitete zraka i doprinijeti razvoju učinkovitijih javnozdravstvenih mjera.Rezultati istraživanja imat će široku primjenu u okolišnim i zdravstvenim politikama, pridonijet će boljem razumijevanju izvora i posljedica onečišćenja zraka, te će biti usklađeni s najnovijim zahtjevima EU regulative o kvaliteti zraka.]]></summary_hr><summary_en><![CDATA[Air pollution caused by airborne particulate matter represents a significant environmental and public health issue, with proven effects on respiratory and cardiovascular diseases. Although their harmfulness has traditionally been assessed based on total mass, it is increasingly evident that the chemical composition of particulate matter plays a crucial role in its toxicity. Organic markers, such as polycyclic aromatic hydrocarbons, polychlorinated biphenyls, elemental and black carbon, levoglucosan, and organic acids, are particularly important as they can influence the oxidative potential (OP) of particulate matter—an indicator of its ability to induce oxidative stress in the human body. Previous research in Europe and globally highlights the need for a better understanding of the relationship between the chemical composition of PM2.5 and its oxidative potential. However, such data have not yet been systematically collected in Croatia and the region. The lack of information on the presence of organic markers, their seasonal and spatial variability, and their connection to oxidative stress represents a scientific gap that this project aims to fill. The project will focus on identifying and quantifying organic markers in PM2.5, determining their oxidative potential, and investigating their potential impact on human health. Through seasonal measurements and laboratory analyses, the project will provide new insights into the toxic components of airborne particulate matter, facilitating improvements in air quality monitoring and contributing to the development of more effective public health measures. The research findings will have broad applications in environmental and health policies, enhance understanding of the sources and consequences of air pollution, and align with the latest EU air quality regulations.]]></summary_en></project><project>
<id>18527</id><title_hr><![CDATA[Nova formulacijska platforma za teško topive API s potencijalom primjene za suho oko - DEAP (Dry Eye API Platform), IP.1.1.03.0044]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4075</user_id><user_firstLast_name>Jasmina Lovrić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-5112</code><acronim><![CDATA[]]></acronim><duration>10.12.2025 - 09.12.2031</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Farmacija, </scie_field_hr><scie_field_en>Pharmaceutical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Farmaceutsko-biokemijski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Pharmacy and Biochemistry]]></institution_en><team_members_id>873033</team_members_id><team_members_names><![CDATA[ Doktorand: Anđela Nosić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>18528</id><title_hr><![CDATA[Transformacija postindustrijskog grada: prostor, zajednica i rad]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4785</user_id><user_firstLast_name>Nevena Škrbić Alempijević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-3642</code><acronim><![CDATA[PostCity]]></acronim><duration>10.12.2025 - 09.12.2031</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Etnologija i antropologija, </scie_field_hr><scie_field_en>Ethnology and anthropology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>872973</team_members_id><team_members_names><![CDATA[ Doktorand: Lea Biličić ]]></team_members_names><keywords_hr><![CDATA[postindustrijski grad, prostor, zajednica, rad, kulturna antropologija, etnografska istraživanja]]></keywords_hr><keywords_en><![CDATA[postindustrial city, space, community, work, cultural anthropology, ethnographic research]]></keywords_en><summary_hr><![CDATA[Projekt PostCity istražuje društvenu dinamiku potaknutu suvremenim procesima deindustrijalizacije iz kulturnoantropološke i kulturnogeografske perspektive. Bavi se postindustrijskom svakodnevicom te načinima na koje se različiti društveni akteri nose sa strukturnim promjenama prouzročenima padom industrije i politikama upravljanja nekadašnjim industrijskim prostorima. Analitički se usmjerava na tri sfere transformacija postindustrijskog grada:1. prostor - društvenu proizvodnju i društvenu konstrukciju postindustrijskih lokaliteta2. rad - politike, prakse i iskustva industrijskih i postindustrijskih oblika rada3. zajednice - stanovništvo nekadašnjih industrijskih područja.PostCity stavlja naglasak na razvojni potencijal nekadašnjih industrijskih kompleksa, na novu kulturnu produkciju, ali i na društvene probleme koje izaziva njihova transformacija. Oslanja se na recentna teorijska polazišta postindustrijske i urbane antropologije, antropologije rada, kulturne geografije i humanističkih znanosti o okolišu. Metodološki se temelji na kvalitativnim pristupima i na dubinskom etnografskom istraživanju. Zato je fokus na jednome gradu – Zagrebu. Na potrebu za sustavnim istraživanjem Zagreba upućuje činjenica da je Sveučilište u Zagrebu 2020. postalo dijelom Europskog sveučilišta postindustrijskih gradova UNIC s ciljem suočavanja s izazovima koje nameće deindustrijalizacija.U četverogodišnjem će projektu sudjelovati šest istraživačica s Filozofskog fakulteta Sveučilišta u Zagrebu, jedna suradnica s Prirodoslovno-matematičkog fakulteta Sveučilišta u Zagrebu i doktorand. Projekt će doprinijeti razvoju stručne ekspertize u području postindustrijske antropologije u Hrvatskoj, kao i znanstveno utemeljenom razumijevanju transformacija postindustrijskog grada kao pitanja od javnog interesa.]]></summary_hr><summary_en><![CDATA[The PostCity project will explore the social dynamics triggered by contemporary processes of deindustrialization from the perspectives of cultural anthropology and cultural geography. It deals with everyday life in a postindustrial city and with the ways in which diverse social agents cope with the structural changes induced by industrial decline and current policies of managing former industrial areas. It relies on three analytical axes and modes of transformation:1. space – the social production and social construction of postindustrial localities,2. work – the policies, practices, and experiences of industrial and postindustrial forms of work,3. communities – the inhabitants of former industrial areas.PostCity emphasises the developmental potential of former industrial complexes and new cultural production, but also the social problems that emerge from their transformation. It combines current insights and theoretical approaches from postindustrial and urban anthropology, the anthropology of work, imaginative geography, and environmental humanities. Methodologically, it is based on qualitative strategies and in-depth ethnographic research. This is why the project focuses on only one city – Zagreb. In 2020, the University of Zagreb became part of the UNIC European University of Postindustrial Cities with the aim of facing the societal challenges caused by deindustrialization. Systematic research on these trends is lacking for Zagreb, which is what PostCity intends to provide.This four-year project’s team includes six employees from the Faculty of Humanities and Social Sciences at the University of Zagreb, one researcher from the Faculty of Science at the University of Zagreb, and one Ph.D. student. PostCity will contribute to the development of professional expertise in the field of postindustrial anthropology in Croatia, as well as to a knowledge-based understanding of transformations in postindustrial cities as a matter of public interest.]]></summary_en></project><project>
<id>18529</id><title_hr><![CDATA[Signalizacija između endoplazmatskog retikuluma i mitohondrija u regulaciji neurodegeneracije i neuroinflamacije ]]></title_hr><title_en><![CDATA[ER-mitochondria signalling in neurodegeneration and neuroinflammation]]></title_en><user_id>12500</user_id><user_firstLast_name>Andrea Markovinović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2025-02</proposal_call><code>UIP-2025-02-2539</code><acronim><![CDATA[ER-mitoNeuroImmuno]]></acronim><duration>01.04.2026 - 31.03.2031</duration><status>U tijeku</status><financ_value>299.517,50 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Medicine]]></institution_en><team_members_id>26262, 870546, </team_members_id><team_members_names><![CDATA[Ana Terezija Jerbić Radetić, Sandra M. Martin Guerrero, ]]></team_members_names><keywords_hr><![CDATA[PTPIP51, VAPB, ER membrane povezane s mitohondrijem, amiotrofična lateralna skleroza/frontotemporalna demencija, neuroinflamacija, neurodegeneracija]]></keywords_hr><keywords_en><![CDATA[PTPIP51, VAPB, mitochondria-associated membranes, amyotrophic lateral sclerosis/frontotemporal dementia,neuroinflammation, neurodegeneration]]></keywords_en><summary_hr><![CDATA[Signalizacija između endoplazmatskog retikuluma (ER) i mitohondrija poremećena je u neurodegenerativnim bolestima, uključujući amiotrofičnu lateralnu sklerozu/frontotemporalnu demenciju (ALS/FTD). Kako bi se omogućila ova signalizacija, ER i mitohondriji stvaraju bliske kontakte koji su omogućeni putem “veznih” proteina, a jedan takav par čine ER protein VAPB i mitohondrijski protein PTPIP51. Poremećena signalizacija između ER i mitohondrija u ALS/FTD-u uključuje prekidanje interakcija između VAPB i PTPIP51 proteina. Signalizacija između ER i mitohondrija regulira niz funkcija koje su narušene u ALS/FTD-u, uključujući Ca2+ signalizaciju, mitohondrijsku ATP proizvodnju, sinaptičku aktivnost, autofagiju i upalne odgovore. Interakcije između VAPB i PTPIP51 proteina reguliraju nekoliko ovih funkcija. Međutim, dosad nemamo dokaza o ulozi interakcije između VAPB i PTPIP51 proteina u neuroinflamaciji, unatoč studijama koje pokazuju da kontaktna mjesta između ER-a i mitohondrija služe kao molekularne platforme za signalizaciju urođene imunosti uključujući aktivaciju RIG-I i STING signalnih puteva. Hipoteza je da PTPIP51-posredovana signalizacija između ER-a i mitohondrija regulira upalu u središnjem živčanom sustavu i/ili sistemski što bi moglo utjecati na ALS/FTD patogenezu. Kako bismo to testirali, kandidatkinja je dizajnirala novi PTPIP51 knockout (PTPIP51 -/-) mišji model i okupila multidisciplinarni istraživački tim koji će razraditi ovu tematiku na nekoliko razina. Specifično, koristiti ćemo vrhunske tehnike molekularne biologije, imunološke tehnike te napredni multi-omics pristup za proučavanje imunoloških odgovora u mikrogliji i makrofagima dobivenim iz PTPIP51 -/- miševa in vitro i ex vivo te ćemo odrediti kako je to povezano s neurodegeneracijom in vivo. Ovaj će projekt razjasniti ulogu signalizacije između ER i mitohondrija putem PTPIP51 proteina u neuroinflamaciji te može utjecati na nove terapijske strategije u neurodegenerativnim bolestima.]]></summary_hr><summary_en><![CDATA[Signalling between the endoplasmic reticulum (ER) and mitochondria is disrupted in neurodegenerative diseases, including amyotrophic lateral sclerosis/frontotemporal dementia (ALS/FTD). To facilitate this signalling, ER and mitochondria form close contacts that are supported by tethering proteins, with one of the best-characterised pairs consisting of ER protein VAPB and mitochondrial protein PTPIP51. Disrupted ER-mitochondria signalling in ALS/FTD involves breaking of the VAPB-PTPIP51 tethers. ER-mitochondria signalling regulates a number of functions that are impaired in ALS/FTD, such as Ca2+ signalling, mitochondrial ATP production, synaptic activity, autophagy and inflammatory responses. There is now solid evidence that the VAPB-PTPIP51 tethers regulate several of these functions. However, as yet, there is no published work on the role of the VAPB-PTPIP51 tethers in neuroinflammation despite studies showing that ER-mitochondria contact sites are molecular platforms for innate immune signalling, including RIG-I and STING activation. This proposal focuses on addressing this lack of knowledge. The underlying hypothesis is that the PTPIP51-mediated ER-mitochondria signalling regulates inflammation in the central nervous system and/or systemically, which could impact ALS/FTD pathogenesis. To test this, the candidate has developed a novel PTPIP51 knockout (PTPIP51 -/-) mouse model and assembled a multidisciplinary research team to comprehensibly address this question at multiple levels. Specifically, we will employ advanced molecular biology and immunological techniques and state-of-the-art multi-omics approaches to investigate immune responses in microglia and macrophages derived from PTPIP51-/-mice, both in vitro and ex vivo, and determine how this links to neurodegeneration in vivo. This project will thus elucidate the role of ER-mitochondria signalling via PTPIP51 tethering in neuroinflammation and may have therapeutic implications for neurodegeneration.]]></summary_en></project><project>
<id>18531</id><title_hr><![CDATA[Konzervacijska medicina - krovni predatori kao pokazatelji zdravlja ekosustava]]></title_hr><title_en><![CDATA[Conservation Medicine – apex predators as sentinels of ecosystem health]]></title_en><user_id>6460</user_id><user_firstLast_name>Magda Sindičić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-1750</code><acronim><![CDATA[COMPASS]]></acronim><duration>15.12.2025 - 14.12.2028</duration><status>U tijeku</status><financ_value>161.970,00 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Veterinarska medicina, Javno zdravstvo i zdravstvena zaštita, </scie_field_hr><scie_field_en>Veterinary medicine, Public health and health services, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Veterinarski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Veterinary Medicine]]></institution_en><team_members_id>870129, 870111, 870109, 5291, 28997, 870061, 870257, 870169, 870152, 870203, 830, 176, 25934, 870283, 870282, 870511, 870542, 870680, </team_members_id><team_members_names><![CDATA[Vesna Mojčec Perko, Ira Toplicanec, Maja Belić, Josipa Habuš, Tomislav Gomerčić, Josip Kusak, Iva Zečević, Iva Benvin, Ivona Ćorić, Gorana Miletić, Maja Lazarus, Nina Bilandžić, Ines Varga, Teodora Sin, Miha Krofel, Caio Graco Roza, John Loehr, Jakub Kubala, ]]></team_members_names><keywords_hr><![CDATA[ris, Lynx lynx, vuk, Canis lupus, toksikologija, bakteriologija, virusologija, ekološki parametri]]></keywords_hr><keywords_en><![CDATA[Eurasian lynx, Lynx lynx, grey wolf, Canis lupus, toxicology, bacteriology, virology, ecological parameters]]></keywords_en><summary_hr><![CDATA[Znanstvena grana konzervacijska medicina izučava utjecaj ekologije populacija divljih životinja na održavanje i prijenos patogena, te u konačnici izučava direktnu poveznica između očuvanja bioraznolikosti i ugroženih vrsta sa zdravljem ljudi. Konzervacijska medicina  povezuje veterinarsku medicinu, toksikologiju, epidemiologiju, javno zdravstvo, ekologiju i konzervacijsku biologiju, a ovakav pristup  do sada nije primijenjen u hrvatskom znanstvenom prostoru. Karizmatični, krovni predatori poput vuka i risa su pouzdan indikator zdravlja ekosustava, a ujedno i snažno privlače pažnju stručne i opće javnosti. Stoga su idealan model za razvoj konzervacijske medicine u Hrvatskoj, prikupljanje znanja o međuutjecaju zagađivala, patogena i ekologije ugroženih vrsta, te primjenu ovih znanja u očuvanju zdravlja ekosustava kojeg dijele ljudi i životinje. Stoga je cilj ovog istraživačkog projekta, skraćenog naziva COMPASS (Conservation Medicine – Predators As Sentinel Species), okupiti multidisciplinarni tim iskusnih stručnjaka i mladih znanstvenika, te primijeniti načela konzervacijske medicine na ugroženim krovnim predatorima vuku i risu. Koristeći  inovativne analitičke metode istražiti će se prisutnost zagađivala i patogena u arhiviranim uzorcima vuka i risa, te prikupiti podatci o ovim ugrozama koji nedostaju u europskom znanstvenom prostoru. Zatim će se primjenom hijerarhijskog modeliranja zajednica vrsta (HMSC) utvrditi kako ekološki i zdravstveni parametri zajednički oblikuju distribuciju i strukturu zajednice sisavaca u našem istraživačkom području. ]]></summary_hr><summary_en><![CDATA[The scientific discipline of conservation medicine investigates the impact of wildlife population ecology on the maintenance and transmission of pathogens. It ultimately explores the direct relationship between biodiversity conservation, endangered species, and human health. Conservation medicine encompasses various fields, including veterinary medicine, toxicology, epidemiology, public health, ecology, and conservation biology—an approach that has yet to be fully embraced by the Croatian scientific community. Charismatic apex predators, such as wolves and lynx, serve as reliable indicators of ecosystem health while drawing the attention of both experts and the public. As such, they present an ideal model for developing conservation medicine in Croatia, model for understanding of the interactions among pollutants, pathogens, and the ecology of endangered species, ultimately leveraging this knowledge to safeguard the health of human and animal ecosystems. The research project COMPASS (Conservation Medicine – Predators As Sentinel Species) aims to unite a multidisciplinary team of experienced and young scientists to apply conservation medicine principles to endangered apex predators — wolves and lynx. Using innovative analytical techniques, the researchers will investigate the presence of contaminants and pathogens in archived samples of wolves and lynx, to gather previously missing data on these threats within the European scientific landscape. Additionally, by employing hierarchical modeling of species communities (HMSC), we will analyze how ecological and health parameters jointly shape the distribution and structure of mammal communities in the study area. ]]></summary_en></project><project>
<id>18534</id><title_hr><![CDATA[Genetski čimbenici i uzgojni stres kao determinante kvalitete i funkcionalnih pokazatelja mesa junadi ]]></title_hr><title_en><![CDATA[Genetic factors and rearing stress as determinants of quality and functional indicators in beef meat]]></title_en><user_id>17605</user_id><user_firstLast_name>Tomislav Mikuš</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2025-02</proposal_call><code>UIP-2025-02-8811</code><acronim><![CDATA[GeSt Beef]]></acronim><duration>19.02.2026 - 18.02.2031</duration><status>U tijeku</status><financ_value>294.800,00 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Veterinarska medicina, </scie_field_hr><scie_field_en>Veterinary medicine, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Veterinarski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Veterinary Medicine]]></institution_en><team_members_id>870398, 26074, 868765, </team_members_id><team_members_names><![CDATA[Aneta Piplica, Marta Kiš, Mladenka Vukšić, ]]></team_members_names><keywords_hr><![CDATA[genetski markeri, uzgojni stres, kvaliteta mesa, proteomika, izvorne pasmine]]></keywords_hr><keywords_en><![CDATA[Genetic markers, rearing stress, meat quality, proteomics, indigenous breeds]]></keywords_en><summary_hr><![CDATA[GeSt Beef projekt istražuje kvalitetu mesa junadi kroz analizu funkcionalnih pokazatelja, uzgojnog stresa, genetskih markera i proteina povezanih sa stresnim odgovorom. Istraživanje obuhvaća tri pasmine: autohtone hrvatske bušu i istarskog boškarina te visokoselekcioniranu pasminu Salers, čiji se genski potencijal u lokalnim uvjetima tek treba istražiti. U prvoj fazi analizirat će se kvaliteta mesa s ciljem utvrđivanja ključnih pokazatelja poput sastava masnih kiselina, pH vrijednosti, boje, udjela vode, masti i proteina. Dobiveni podaci poslužit će kao temelj za daljnju korelaciju s uzgojnim stresom, genetskim markerima i proteomskim rezultatima te omogućiti usporedbu autohtonih pasmina s pasminom Salers. Sljedeća faza istraživanja usmjerena je na identifikaciju genetskih markera povezanih s kvalitetom mesa. Analiza uzoraka krvi omogućit će usporedbu specifičnih genetskih varijanti među pasminama, s naglaskom na razlike između autohtonih pasmina i pasmine Salers. Konačna korelacija ovih markera s funkcionalnim pokazateljima mesa pružit će dublji uvid u utjecaj genskih mutacija na kvalitetu mesa. Završna faza obuhvatit će analizu proteina povezanih sa stresnim odgovorom i kvalitetom mesa. Proteomska analiza provest će se na uzorcima sline, seruma i mesa kako bi se identificirali novi biomarkeri. Unatoč manjem broju uzoraka zbog visokih troškova analize, ovo će istraživanje prvi put pružiti podatke o stresnim proteinima u mesu hrvatskih autohtonih pasmina.]]></summary_hr><summary_en><![CDATA[The GeSt Beef project investigates beef quality through the analysis of functional indicators, rearing stress, genetic markers, and proteins associated with the stress response. The research focuses on three cattle breeds: the Croatian indigenous breeds Buša and Istrian Boškarin, as well as the highly selected Salers breed, whose genetic potential in local conditions has yet to be thoroughly explored. In the first phase, meat quality will be analyzed to determine key indicators such as fatty acid composition, pH value, colour, water content, fat, and protein levels. The collected data will serve as a basis for further correlation with rearing stress, genetic markers, and proteomic results, providing a reference for comparing indigenous breeds with the Salers breed. The next phase will focus on identifying genetic markers associated with meat quality. Blood sample analysis will enable a comparison of specific genetic variants among breeds, with an emphasis on differences between indigenous breeds and the Salers breed. The final correlation of these markers with functional meat indicators will provide deeper insight into the impact of genetic mutations on meat quality. The final phase will include an analysis of proteins related to the stress response and meat quality. Proteomic analysis will be conducted on saliva, serum, and meat samples to identify new biomarkers. Despite the smaller sample size due to high analytical costs, this research will provide the first-ever data on stress-related proteins in the meat of Croatian indigenous breeds.]]></summary_en></project><project>
<id>18543</id><title_hr><![CDATA[Swarm of Energy Harvesting Floaters for the Detection of Vessel threats (SHIELD)]]></title_hr><title_en><![CDATA[]]></title_en><user_id>19282</user_id><user_firstLast_name>Hrvoje Džapo</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-3134</code><acronim><![CDATA[]]></acronim><duration>21.11.2025 - 20.11.2031</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>872932</team_members_id><team_members_names><![CDATA[ Doktorand: Marija Milanović ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>18544</id><title_hr><![CDATA[Napredne i održive metode analize novih lijekova za upalne bolesti crijeva ]]></title_hr><title_en><![CDATA[Advanced and Sustainable Methods for Analysing New Drugs for Inflammatory Bowel Disease]]></title_en><user_id>1301</user_id><user_firstLast_name>Ana Mornar Turk</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-2541</code><acronim><![CDATA[SMART-IBD]]></acronim><duration>20.01.2026 - 19.01.2029</duration><status>U tijeku</status><financ_value>199.400,00 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Farmacija, </scie_field_hr><scie_field_en>Pharmaceutical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Farmaceutsko-biokemijski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Pharmacy and Biochemistry]]></institution_en><team_members_id>870215, 4214, 868220, 905, 6406, 866338, 868129, 866479, 865187, 870172, 868130, </team_members_id><team_members_names><![CDATA[Harriet Bennett-Lenane, Željko Krznarić, Siniša Tomić, Daniela Amidžić Klarić, Nikša Turk, Ivona Jasprica, Snježana Zubčić, Valentina Petruševska, Jelena Kovačić, Petra Bajt, Vladimir Stankov, ]]></team_members_names><keywords_hr><![CDATA[upalne bolesti crijeva, etrasimod, ritlecitinib, zelena analitička kemija, superkritična fluidna kromatografija]]></keywords_hr><keywords_en><![CDATA[inflammatory bowel disease, etrasimod, ritlecitinib, green analytical chemistry, supercritical fluid chromatography]]></keywords_en><summary_hr><![CDATA[Upalne bolesti crijeva, Crohnova bolest i ulcerozni kolitis, spadaju u kronične bolesti obilježene čestim izmjenama kliničkih pogoršanja i mirnih faza bolesti. Posljednjih godina znanstvena istraživanja usmjerena su na razvoj novih lijekova s inovativnim mehanizmima djelovanja za liječenje ove progresivne bolesti. Etrasimod (modulator receptora sfingozin-1-fosfata) i ritlecitinib (inhibitor Janus kinaza) kao visoko selektivni lijekovi predstavljaju novu generaciju lijekova koji čine prekretnicu u liječenju upalnih bolesti crijeva. Predloženo istraživanje ima za cilj razvoj naprednih i pouzdanih analitičkih metoda primjenjivih u farmaceutskim i kliničkim studijama etrasimoda i ritlecitiniba. Zelena analitička kemija postala je temelj moderne znanosti, potičući razvoj održivih tehnologija koje smanjuju utjecaj na okoliš i povećavaju sigurnost za ljude i ekosustave. Temelji se na 12 načela koja daju prednost ekološkoj odgovornosti, uključujući sprječavanje nastanka otpada, korištenje ekološki prihvatljivih otapala i reagensa, primjenu obnovljivih materijala te energetsku učinkovitost. Stoga će razvoj metoda biti usmjeren prema implementaciji načela zelene analitičke kemije primjenom raznovrsnih inovativnih tehnologija i procesa. Prva faza istraživanja bit će usmjerena na razvoj ekološki prihvatljivih metoda za određivanje sadržaja lijekova i njihovih onečišćenja te stabilitetno-indikativnih metoda. U drugoj fazi istraživanje će biti usmjereno na studije prisilne razgradnje kako bi se prikupili podaci o stabilnosti lijekova kao i na ispitivanje kompatibilnosti lijekova i pomoćnih tvari. Treća faza istraživanja bit će posvećena razvoju održivih bioanalitičkih metoda prikladnih za terapijsko praćenje lijekova u kliničkim laboratorijima. Razvojem zelenih analitičkih metoda za ove inovativne lijekove, istraživačka grupa će ostvariti značajan znanstveni napredak u ovom atraktivnom, interdisciplinarnom i međunarodno relevantnom području istraživanja.]]></summary_hr><summary_en><![CDATA[Inflammatory bowel disease, including Crohn’s disease and ulcerative colitis, is a chronic condition characterized by alternating episodes of relapse and remission. In recent years, scientific research has focused on developing new drugs with innovative mechanisms of action to treat this progressive disease. Etrasimod (sphingosine-1 phosphate receptor modulator) and ritlecitinib (Janus kinase inhibitor), as highly selective drugs, represent a new generation of therapies that mark a breakthrough in the treatment of inflammatory bowel disease. The proposed research aims to develop advanced and reliable analytical methods applicable in pharmaceutical and clinical studies of etrasimod and ritlecitinib. Green analytical chemistry has emerged as a cornerstone of modern science, promoting the development of sustainable technologies that reduce environmental impact and enhance safety for humans and ecosystems. It is based on 12 principles that prioritize environmental responsibility, including waste prevention, the use of environmentally friendly solvents and reagents, the application of renewable materials, and energy efficiency. Therefore, method development will focus on implementing the principles of green analytical chemistry through various innovative technologies and processes. The first phase of the research will focus on developing environmentally friendly methods for determining drug content and impurities, as well as stability-indicating methods. The second phase will involve forced degradation studies to gather data on drug stability and assess drug-excipient compatibility. The third phase of the research will be dedicated to developing sustainable bioanalytical methods suitable for therapeutic drug monitoring in clinical laboratories. By developing green analytical methods for these innovative drugs, the research group will achieve significant scientific progress in this highly attractive, interdisciplinary, and internationally relevant research field.]]></summary_en></project><project>
<id>18545</id><title_hr><![CDATA[Wireless deep brain stimulation through engineered multifunctional nanomaterials]]></title_hr><title_en><![CDATA[]]></title_en><user_id>27172</user_id><user_firstLast_name>Tomislav Marković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-5355</code><acronim><![CDATA[]]></acronim><duration>04.11.2025 - 03.11.2031</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>872920</team_members_id><team_members_names><![CDATA[ Doktorand: Ivan Budić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>18548</id><title_hr><![CDATA[Pametna nanobiotehnološka platforma za unaprjeđenje dijagnostičkih, prognostičkih i terapijskih pristupa kod raka gušterače]]></title_hr><title_en><![CDATA[Smart nanobiotechnological platform for advancing diagnostic, prognostic and therapeutic approaches for pancreatic cancer]]></title_en><user_id>573</user_id><user_firstLast_name>Ivana Vinković Vrček</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-1762</code><acronim><![CDATA[SPARK]]></acronim><duration>01.12.2025 - 30.11.2028</duration><status>U tijeku</status><financ_value>199.000,00 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Biotehnologija, Interdisciplinarne biotehničke znanosti, </scie_field_hr><scie_field_en>Biotechnology, Interdisciplinary biotechnical sciences, </scie_field_en><institution_hr><![CDATA[Institut za medicinska istraživanja i medicinu rada]]></institution_hr><institution_en><![CDATA[Institute for Medical Research and Occupational Health]]></institution_en><team_members_id>29014, 861725, 865025, 870688, 19967, 3204, 858452, 3133, 869867, 20211, 12988, 870490, 870987, </team_members_id><team_members_names><![CDATA[Nikolina Kalčec, Lucija Božičević, Nikolina Peranić, Indira Benjak Horvat, Monika Ulamec, Slavko Gašparov, Ivan Mamić, Petra Turčić, Mateo Celinić, Goran Hauser, Mirko Poljak, Reinier Oropesa Nunez, Mario Tadić, ]]></team_members_names><keywords_hr><![CDATA[organoidi raka, nanolijekovi, mikroskopija atomskih sila, oslikavanje spektrometrijom masa,karcinom gušterače, personalizirana testna platforma]]></keywords_hr><keywords_en><![CDATA[cancer organoids, nanodrugs, atomic force microscopy, mass spectrometry imaging, pancreatic cancer, personalized testing platform]]></keywords_en><summary_hr><![CDATA[Glavni cilj projekta je razviti standardiziranu nanobiotehnološku platformu za unaprjeđenje pretkliničkih istraživanja u razvoju učinkovitijih dijagnostičkih, prognostičkih i terapijskih pristupa u liječenju raka gušterače. Ova platforma kombinira inovativne personalizirane 3D in vitro modele (organoide) raka gušterače s bioanalitičkim alatima koji omogućuju preciznu i brzu patofiziološku analizu, a temelje se na mikroskopiji atomskih sila, visokoprotočnoj fluorescentnoj mikroskopiji te metabolomičkom profiliranju pomoću oslikavanja masenom spektrometrijom. Takva platforma omogućava brzo i učinkovito testiranje inovativnih terapijskih pristupa, kao i učinkovitije dijagnostičko i prognostičko praćenje raka gušterače.]]></summary_hr><summary_en><![CDATA[The main objective of the project is to develop a standardized nanobiotechnology platform to advance preclinical research in the development of more effective diagnostic, prognostic and therapeutic approaches in the treatment of pancreatic cancer. This platform combines innovative personalized 3D in vitro pancreatic cancer models (organoids)  with bioanalytical tools that enable precise and rapid pathophysiological analysis, based on atomic force microscopy, high-throughput fluorescence microscopy and metabolomic profiling by mass spectrometry imaging. Such a platform allows for rapid and efficient testing of innovative therapeutic approaches, as well as more effective diagnostic and prognostic monitoring of pancreatic cancer.]]></summary_en></project><project>
<id>18558</id><title_hr><![CDATA[Karakterizacija hipotalamičkih neurona koji izražavaju urogvanilin u muških i ženskih miševa i ljudi]]></title_hr><title_en><![CDATA[Characterization of URoguanylin-Expressing hypothalamic neurons in male and female mice and humans]]></title_en><user_id>5255</user_id><user_firstLast_name>Aleksandra Dugandžić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-8273</code><acronim><![CDATA[CURE]]></acronim><duration>15.12.2025 - 14.12.2028</duration><status>U tijeku</status><financ_value>196.765,00 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>12975, 19503, 4921, </team_members_id><team_members_names><![CDATA[Nikola Habek, Milan Kordić, Vladiana Crljen, ]]></team_members_names><keywords_hr><![CDATA[novi protein u mozgu, razlike odnosu na fazu spolnog ciklusa, smeđe masno tkivo, šećerna bolest tipa 2, pretilost]]></keywords_hr><keywords_en><![CDATA[new protein in the brain, differences in relation to the phase of the sexual cycle, brown adipose tissue, type 2 diabetes, obesity]]></keywords_en><summary_hr><![CDATA[Šećerna bolest tipa 2 (eng. Type 2 Diabetes Mellitus, T2DM) i pretilost predstavljaju značajan teret za čovječanstvo u suvremenom svijetu, stoga su pretkliničke i kliničke studije o inzulinskoj rezistenciji i homeostazi glukoze neophodne. Funkcija urogvanilina (UGN) ovisi o spolu i u hipotalamusu može igrati značajnu ulogu u regulaciji metabolizma glukoze i tjelesne težine tako da smanjuje unos hrane (potiče sitost) i povećava aktivnosti smeđeg masnog tkiva (eng. brown adipose tissue, BAT) (postprandijalna potrošnja glukoze). U miševa, promjene izražaja prekursora UGN-a (proUGN) u hipotalamusu nakon obroka ovise o spolu i fazi spolnog ciklusa. Kod ljudi, izražaj proUGN-a u hipotalamusu pretilih muških, ali ne i ženskih osoba, niža je u usporedbi s osobama normalne tjelesne težine. Spolne razlike u moždanoj funkciji UGN-a mogu se pojaviti zbog razlike u izražaju receptora za UGN (gvanilat ciklaza C (GC-C)) ili samog hormona. Budući da je mehanizam djelovanja UGN-a u hipotalamusu nepoznat, a funkcija UGN-a ovisi o spolu, dva su glavna cilja ove studije: 1. odrediti neurone koji izražavaju GC-C ili UGN u hipotalamusu miševa i ljudi i spolne razlike u njihovoj postprandijalnoj regulaciji; 2. odrediti neuralne putove hipotalamičkih neurona koji eksprimiraju UGN u mužjaka i ženki miševa. Da bi se UGN mogao koristiti kao nova terapijska strategija za povećanje BAT aktivnosti, sitosti i za postprandijalnu regulaciju glukoze u bolesnika s pretilošću i T2DM-om, bolje razumijevanje fiziološkog i patofizioloških mehanizma djelovanja UGN-a je potrebno. Posebice je važno istražiti spolne razlike u tim mehanizmima koje bi mogle dovesti do razlika u terapijskim pristupima u muških i ženskih pacijenata.]]></summary_hr><summary_en><![CDATA[Type 2 diabetes mellitus (T2DM) and obesity represent a significant burden for humanity in the modern world therefore, preclinical and clinical studies on insulin resistance and glucose homeostasis are essential. The function of uroguanylin (UGN) is gender dependent and in the hypothalamus may play a significant role in the regulation of glucose metabolism and body weight by decreasing food intake (satiety) and increase brown adipose tissue (BAT) activity (postprandial glucose consumption). In mice, changes of postprandial proUGN expression in hypothalamus is sex and stage of estrous cycle dependent. In humans, the expression of UGN precursor (proUGN) in hypothalamus of obese male, but not female individuals, is lower when compared to individuals with normal body weight. Gender differences in UGN brain function could occur due to difference in expression of receptor for UGN (guanylate cyclase C (GC-C)) or the hormone itself. Since the mechanism of UGN action in the hypothalamus is unknown and the function of UGN is gender dependent, there are two main goals in this study: 1. to determine neurons expressing GC-C or UGN in hypothalamus of mice and humans and the sex differences in their postprandial regulation 2. to determine neural pathways of hypothalamic neurons expressing UGN in male and female mice. In order for UGN to be used as a new therapeutic strategy to increase BAT activity, satiety and for postprandial glucose regulation in patients with obesity and T2DM, a better understanding of the physiological and pathophysiological mechanisms of action of UGN is necessary. It is especially important to investigate gender differences in these mechanisms that could lead to differences in therapeutic approaches in male and female patients.]]></summary_en></project><project>
<id>18559</id><title_hr><![CDATA[Odgovor na inovacije u fenomici I genomici u oplemenjivanju mliječnih goveda]]></title_hr><title_en><![CDATA[]]></title_en><user_id>23378</user_id><user_firstLast_name>Nataša Mikulec</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-3357</code><acronim><![CDATA[PhenoGeno]]></acronim><duration>02.12.2025 - 01.12.2031</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Agronomski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Agriculture]]></institution_en><team_members_id>872952</team_members_id><team_members_names><![CDATA[ Doktorand: Dario Domović ]]></team_members_names><keywords_hr><![CDATA[Govedarstvo, proizvodnja mlijeka, genomika, fenomika, kvantitativna genetika]]></keywords_hr><keywords_en><![CDATA[Cattle breeding, Dairy production, Genomics, Phenomics, Quantitative genetics]]></keywords_en><summary_hr><![CDATA[Primjena novih pristupa fenotipizaciji, napredna genotipizacija (genotipizacija visoke propusnosti na razini cijelog genoma, SNP nizovi) te genomski i statistički razvoj (genomska selekcija i one-step GBLUP) doveli su do ubrzanog genetičkog napretka u svim zemljama u razvoju mljekarstva. To vrijedi i za druga područja uzgoja životinja. Nažalost, Hrvatska je tek umjereno odgovorila na nova zbivanja, a naši uzgojni programi trenutačno uključuju samo relativno mali broj genotipiziranih krava i bikova na razini genoma. Istodobno, broj genotipiziranih životinja u razvijenim zemljama prelazi 100 000 životinja (> 300 000 goveda SNP-a u Austriji). Stoga smo odlučili predložiti moderan projekt u kojem ćemo razviti uzoran inovativni uzgojni program (s GWAS-om i procjenom genomskih parametara hrvatske holstein pasmine) koristeći najnovija tehnološka dostignuća u fenomici i genomici. U našem prijedlogu odlučili smo otići korak dalje od SNP nizova koji se danas rutinski koriste i temeljiti našu strategiju genotipizacije na najnovijoj mogućnosti (niskopropusno sekvenciranje cijelog genoma, lpWGS), jer bi to mogla biti najbolja strategija u našim relativno malim populacijama . Istodobno, naša napredna strategija fenotipizacije bila je usmjerena na uvođenje velikih mjerenja svojstava zgrušavanja mlijeka izvedenih iz FTIR spektra, budući da bi razvoj proizvodnje sira, kao u sjevernoj Italiji, mogao biti dobra strategija za hrvatski mljekarski sektor. Dok naš projekt ima vrlo snažnu primjenjivu komponentu, također smo ponudili niz analiza testirajući učinke zanemarenog nasljeđivanja, točnije učinke X-kromosoma i mito-nuklearnih interakcija na kvantitativne osobine (uključujući štetne aspekte), koje su prilično nove i revolucionarne hipoteze za uzgoj životinja, ali i za evolucijsku genetiku. Jedan mali aspekt projekta je &#39;&#39;igranje&#39;&#39; (eksperimentiranje) s detekcijom mikrobiote mlijeka iz lpWGS datoteka (FASTAq).]]></summary_hr><summary_en><![CDATA[The application of new phenotyping approaches, advanced genotyping (high-throughput genome-wide genotyping, SNP arrays), and genomic and statistical developments (genomic selection and one-step GBLUP estimation) have led to accelerated genetic progress in all dairy developing countries. This is also true for other areas of animal breeding. Unfortunately, Croatia has responded only moderately to the new developments, and our breeding programs currently include only a relatively small number of genome-wide genotyped cows and bulls. At the same time, the number of genotyped animals in developed countries exceeds 100,000 animals (> 300,000 SNP-arrayed cattle in Austria). Therefore, we decided to propose a modern project in which we will develop an exemplary innovative breeding program (with GWAS and estimation of genomic parameters in Croatian Holstein breed) using the latest technological advances in phenomics and genomics. In our proposal, we decided to go a step further than the SNP arrays routinely used today and base our genotyping strategy on the latest possibility (low-pass whole genome sequencing, lpWGS), as this might be the best strategy in our relatively small populations. At the same time, our advanced phenotyping strategy focused on introducing large-scale measurements of milk coagulation traits derived from FTIR spectra, as the development of cheese production, as in northern Italy, could be a good strategy for the Croatian dairy sector. While our project has a very strong applicable component, we have also offered a series of analyses testing the effects of neglected inheritance, more specifically the effects of X-chromosome and mito-nuclear interactions on quantitative traits (including deleterious aspects), which are quite new and ground-breaking hypotheses for animal breeding, but also for evolutionary genetics. One small aspect of the project is &#39;&#39;playing&#39;&#39; (experimenting) with detection of milk microbiota from lpWGS files (FASTQ).]]></summary_en></project><project>
<id>18562</id><title_hr><![CDATA[Napredna dijagnostika i prognostika za učinkovitu proizvodnju i korištenje zelenog vodika]]></title_hr><title_en><![CDATA[Advanced diagnostics and prognostics for efficient production and use of green hydrogen]]></title_en><user_id>17740</user_id><user_firstLast_name>Ivan Pivac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2025-02</proposal_call><code>UIP-2025-02-6150</code><acronim><![CDATA[HYTECH]]></acronim><duration>19.02.2026 - 18.02.2031</duration><status>U tijeku</status><financ_value>258.940,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, Kemijsko inženjerstvo, </scie_field_hr><scie_field_en>Mechnical engineering, Chemical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Fakultet elektrotehnike, strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Electrical Engineering, Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>855326, 25327, 870296, 870150, 870623, 870242, </team_members_id><team_members_names><![CDATA[Jakov Šimunović, Andrej Zvonimir Tomić, Anamarija Stoilova Pavasović, Nikola Franić, Quentin Meyer, Marco Bogar, ]]></team_members_names><keywords_hr><![CDATA[vodik, gorivni članak, elektrolizator, elektrokemijski pročišćivač, kompresor, hibridni energetski sustav, dijagnostika, prognostika, degradacija]]></keywords_hr><keywords_en><![CDATA[hydrogen, fuel cell, electrolyzer, electrochemical purifier, compressor, hybrid renewable energy system, diagnostics, prognostics, degradation]]></keywords_en><summary_hr><![CDATA[Novoosnovana istraživačka grupa unutar Laboratorija za vodikove tehnologije na FESB-u će se baviti unaprjeđivanjem postojećih i razvojem novih dijagnostičkih i prognostičkih metoda membranskih elektrolizatora i gorivnih članaka, uređaja za elektrokemijsku kompresiju i pročišćavanje vodika, te razvojem učinkovitog upravljanja radom ovih komponenti unutar samostalnog hibridnog energetskog sustava s obnovljivim izvorima na temelju poznavanja njihovih radnih karakteristika i utjecaja gubitka kapaciteta. Petogodišnji radni plan je usmjeren prvo u razvoj brzih dijagnostičkih indikatora za praćenje progresije degradacije performansi elektrolizatora za vrijeme proizvodnje zelenog vodika. Na temelju prikupljenih podataka razvit će se model temeljen na metodama strojnog učenja za prognostiku radnih karakteristika elektrolizatora s ciljem poboljšanja njihove trajnosti i učinkovitosti. Također, razvijat će se i praktična procedura za učinkovito odstranjivanje tragova korozije unutar elektrolizatora uslijed progresije degradacije. Što se tiče gorivnih članaka, razvijat će se brza i učinkovita procedura upućivanja u rad, kao i lokalizirana in situ dijagnostika za detekciju i prevenciju pojava plavljenja i sušenja unutar članka tijekom proizvodnje električne energije iz vodika. S ciljem razvoja učinkovitog pročišćavanja tzv. sivog vodika, ispitat će se mogućnosti korištenja membranskog gorivnog članka s prilagođenim radnim parametrima. Što se tiče kompresije vodika, koja je itekako potrebna da bi se vodik mogao skladištiti i praktično koristiti u različitim primjenama, razvijat će se upravljački model koji bi na temelju prilagođavanja radnih parametara uređaja za elektrokemijsku kompresiju vodika i periodičkih snimanja različitih elektrokemijskih dijagnostičkih tehnika trebao postići prikladnu količinu vode s obje strane membrane, pa tako i stabilne performanse tijekom višesatnog rada koje su kritične za potencijalnu komercijalizaciju ove tehnologije.]]></summary_hr><summary_en><![CDATA[A newly established research group within the Laboratory for Hydrogen Technologies at FESB will focus on enhancing diagnostic and prognostic methods for proton exchange membrane water electrolyzers and fuel cells, devices for electrochemical hydrogen compression and purification, and developing effective control strategies for integrating these components into stand-alone hybrid renewable energy systems, considering their operating characteristics and capacity loss impacts. The five-year work plan begins with developing rapid diagnostic indicators to monitor the progression of electrolyzer performance degradation during green hydrogen production. Based on collected data, a machine learning-based model will be developed to predict electrolyzer operating characteristics, aiming to improve durability and efficiency. A practical procedure will also be designed for effectively removing corrosion traces caused by the progression of degradation. For fuel cells, a fast and efficient activation procedure will be developed, alongside localized in situ diagnostics to detect and prevent flooding and drying phenomena during electricity generation. In the field of hydrogen purification, research will explore the use of proton exchange membrane fuel cells with adjusted operating parameters for efficient gray hydrogen purification. Regarding hydrogen compression, a control model will be developed to adjust operating parameters in electrochemical hydrogen compression devices. By periodically recording electrochemical diagnostic techniques, this model will ensure the appropriate water balance on both sides of the membrane, achieving stable multi-hour performance—critical for potential commercialization of this technology.]]></summary_en></project><project>
<id>18566</id><title_hr><![CDATA[Alternativno prekrajanje gena BPM2 kao mehanizam uspostave funkcionalne raznolikosti porodice proteina MATH-BTB u uročnjaku Arabidopsis thaliana]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3746</user_id><user_firstLast_name>Dunja Leljak-Levanić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-8871</code><acronim><![CDATA[SpliceFun]]></acronim><duration>23.01.2026 - 22.01.2032</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>873053</team_members_id><team_members_names><![CDATA[ Doktorand: Klara Uhrl ]]></team_members_names><keywords_hr><![CDATA[alternativno prekrajanje transkripata, BPM2, ekspresija gena, embriogeneza, MATH-BTB, proteinske interakcije, razvoj biljaka, stres, temperatura]]></keywords_hr><keywords_en><![CDATA[alternative splicing, BPM2, embryogenesis, gene expression, MATH-BTB, plant development, protein interactions, stress, temperature]]></keywords_en><summary_hr><![CDATA[Funkcionalna karakterizacija nekoliko članova porodice proteina MATH-BTB razotkrila je njihovu ulogu u širokom spektru važnih bioloških procesa, od regulacije stanične diobe, segregacije kromosoma u reproduktivnom razvoju i embriogenezi, do globalne kontrole metilacije DNA i regulacije transkripcije. Zanimljiva značajka porodice je ekspanzija članova u travama, kod kojih većina MATH-BTB gena ne sadrži introne. Nasuprot tome, samo šest MATH-BTB gena (BPM1-6) uročnjaka sadrži introne te neki od njih kodiraju nekoliko alternativnih varijanti transkripata te eventualno i proteina s potencijalno različitim funkcijama. Ciljevi ovog projekta su identifikacija novih varijanti alternativnog prekrajanja gena BPM2, specifičnih za različita tkiva/razvojne faze i temperature okoliša te njihova funkcionalna karakterizacija na temelju identifikacije proteinskih partnera. Nadalje, najunikatnija varijanta transkripta bit će odabrana za identifikaciju specifičnih partnerskih proteina koji će ukazati na moguće nove biološke funkcija gena BPM2 i porodice MATH-BTB, općenito.]]></summary_hr><summary_en><![CDATA[Functional characterization of few members of MATH-BTB protein family revealed their roles in a wide spectrum of essential biological processes, from regulation of cell division, chromosome segregation in reproductive development and embryogenesis, to global control of DNA methylation and regulation of transcription. The interesting feature of the family is expansion of members in grasses in which most of the MATH-BTB genes contain no introns. In contrast, the six MATH-BTB genes (BPM1-6) in Arabidopsis contain introns and encode up to five splice variants per gene, resulting in proteins with potentially different functions. The goals of the project are identification of new splice variants of BPM2, specific for different tissues/developmental stages and environmental temperatures, and functional characterization of selected BPM2 protein isoforms based on their protein partners. Moreover, a unique splicing variant will be selected for identification of its specific partner proteins, which will point to possible new functions of BPM2 and the MATH-BTB family in general.]]></summary_en></project><project>
<id>18568</id><title_hr><![CDATA[Pheno4P: Fenomski pristup stvaranju premium proizvoda od svinjskog mesa]]></title_hr><title_en><![CDATA[Pheno4P: Phenomic approach to the production of premium pork products]]></title_en><user_id>7603</user_id><user_firstLast_name>Ivona Djurkin Kušec</user_firstLast_name><svouser_id>868414</svouser_id><svouser_firstLast_name>Martin Škrlep</svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-7984</code><acronim><![CDATA[Pheno4P]]></acronim><duration>30.12.2025 - 29.12.2028</duration><status>U tijeku</status><financ_value>200.000,00 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, Prehrambena tehnologija, </scie_field_hr><scie_field_en>Agriculture, Food technology, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Fakultet agrobiotehničkih znanosti Osijek]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Agrobiotechnical Sciences in Osijek]]></institution_en><team_members_id>1296, 6830, 12377, 4653, 4574, 866217, 19702, 25149, 21418, 19548, 25437, 6046, 870592, 870588, 13307, </team_members_id><team_members_names><![CDATA[Goran Kušec, Vladimir Margeta, Zlata Kralik, Kristina Gvozdanović, Andrijana Rebekić, Sanja Jelić Milković, Danijel Karolyi, Zoran Luković, Dubravko Škorput, Miodrag Komlenić, Krešimir Mastanjević, Nives Marušić Radovčić, Predrag Ikonić, Tatjana Peulić, Ivan Kelić, ]]></team_members_names><keywords_hr><![CDATA[pig, indigenous breed, premium product, RNA sequencing, consumer]]></keywords_hr><keywords_en><![CDATA[svinja, lokalna pasmina, premijski proizvod, RNA sekvenciranje, potrošač]]></keywords_en><summary_hr><![CDATA[Svinjogojstvo je ključna grana stočarske proizvodnje, no intenzivna selekcija modernih pasmina često smanjuje senzorska i nutritivna svojstva mesa. Tradicionalni proizvodi, poput slanine, sve su cjenjeniji na tržištu, no još uvijek nisu dovoljno istraženi s aspekta utjecaja genetskih i okolišnih čimbenika na njihovu kvalitetu. Razumijevanje interakcije genotipa i fenotipa ključno je za optimizaciju uzgoja i valorizaciju autohtonih pasmina, koje se ističu specifičnim nutritivnim i senzorskim karakteristikama.Kombinirajući najnovija istraživanja s praktičnim primjenama, projekt Pheno4P poboljšat će znanstveno razumijevanje povezanosti genetskih čimbenika i fenotipskih karakteristika te podržati održivu i ekonomičnu proizvodnju svinjskog mesa. Cilj je istražiti razlike u rastu, sastavu masnih kiselina i kakvoći proizvoda između autohtonih i modernih pasmina, s posebnim fokusom na slaninu kao premijski proizvod. Primjenom fenotipskih analiza, transkriptomske sekvencijacije i epigenetskih istraživanja dobit će se uvid u metaboličke mehanizme ključne za kvalitetu proizvoda.Uz znanstvenu valorizaciju proizvoda, istraživanje će uključiti analizu stavova potrošača i primjenu neuromarketinških metoda kako bi se istražila percepcija slanine. Rezultati projekta koristit će poljoprivredi, prehrambenoj industriji i ruralnoj ekonomiji jačanjem ekonomske održivosti malih proizvođača i povećanjem tržišne atraktivnosti tradicionalnih svinjskih proizvoda. Na taj način, projekt ne samo da doprinosi znanstvenom razumijevanju složenih bioloških mehanizama, već pruža konkretne koristi za razvoj održivih proizvodnih strategija i jačanje konkurentnosti tradicionalnih proizvoda.]]></summary_hr><summary_en><![CDATA[Pig breeding is an key branch of livestock production, but the intensive selection of modern breeds often reduces the sensory and nutritional properties of the meat. Traditional products such as bacon are increasingly valued on the market, but the influence of genetic and environmental factors on their quality has not yet been sufficiently researched. Understanding the interactions between genotype and phenotype is crucial for the optimisation of breeding strategies and valorising autochthonous breeds, which stand out for their specific nutritional and sensory properties.By combining cutting-edge research and practical applications, the Pheno4P project will improve the scientific understanding of the relationship between genetic factors and phenotypic traits while supporting sustainable and economically viable pork production. The aim of the project is to investigate the differences in growth, fatty acid composition and product quality between autochthonous and modern breeds, with a special focus on bacon as a premium product. Phenotypic analyses, transcriptomic sequencing and epigenetic studies will be used to gain insights into the most key metabolic mechanisms that determine product quality.In addition to the scientific valorisation of the products, the research also includes an analysis of consumer attitudes and the application of neuromarketing methods to investigate the perception of bacon. The results of the project will benefit agriculture, the food industry and the rural economy by strengthening the economic sustainability of small-scale farmers and increasing the market attractiveness of traditional pork products. In this way, the project not only contributes to the scientific understanding of complex biological mechanisms, but also offers tangible benefits for the development of sustainable production strategies and the competitiveness of traditional products.]]></summary_en></project><project>
<id>18569</id><title_hr><![CDATA[Okolišni aspekti SARS-CoV-2 antivirotika]]></title_hr><title_en><![CDATA[]]></title_en><user_id>20856</user_id><user_firstLast_name>Matija Cvetnić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-5213</code><acronim><![CDATA[EnA-SARS]]></acronim><duration>12.11.2025 - 11.11.2031</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Kemijsko inženjerstvo, </scie_field_hr><scie_field_en>Chemical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet kemijskog inženjerstva i tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Chemical Engineering and Technology]]></institution_en><team_members_id>872900</team_members_id><team_members_names><![CDATA[ Doktorand: Luka Večenaj ]]></team_members_names><keywords_hr><![CDATA[ onečišćene vode, SARS-CoV-2, antivirotici, okolišni aspekti, biodegradacija, napredni oksidacijski procesi]]></keywords_hr><keywords_en><![CDATA[polluted waters, SARS-CoV-2, antivirals, environmental aspects, biodegradation, advanced oxidation processes]]></keywords_en><summary_hr><![CDATA[Znanstvenici diljem svijeta trenutno su fokusirani na ispitivanje utjecaja SARS-CoV-2 virusa na ljude te pronalaženje načina za sprječavanje ili barem ublažavanje simptoma COVID-19 bolesti. Međutim postoje i neki drugi aspekti vezani uz COVID-19 koje također treba detaljno istražiti. Među njima bismo istaknuli okolišni utjecaj antivirotika koji se koriste protiv SARS-CoV-2 virusa. Kao i kod većine lijekova, tako i kod antivirotika, ljudsko tijelo metabolizira 60-70 % aktivne supstance. Zaostali metaboliti i nemetabolizirana tvar izlučuju se iz tijela te završavaju u otpadnim vodama. Drugi mogući izvori antivirotika u otpadnim vodama uključuju bolnički otpad, otpadne vode farmaceutske industrije te odlaganje neiskorištenih lijekova ili lijekova s isteklim rokom valjanosti. Poznato je da konvencionalna postrojenja za pročišćavanje otpadnih voda većinu farmaceutika ne uklanjaju dovoljno učinkovito. Stoga ne čudi da su brojne studije potvrdile prisutnost antivirotika u vodenom okolišu, što predstavlja ozbiljan rizik za okoliš. Sudbina i ponašanje SARS-CoV-2 antiviralnih supstanci (SAS) u vodenom okolišu relativno su nepoznati. Ujedno, mali je i broj dosad objavljenih istraživanja o uklanjanju SAS-a iz okoliša. Stoga je glavna nakana EnA-SARS projekta rasvijetliti sudbinu i ponašanje SAS-a u okolišu što je ključno za procjenu stvarnog rizika po okoliš. Pri tome će provesti procjena ekotoksikološkog rizika uključujući i moguće sinergističko djelovanje SAS-a. Nadalje, ispitat će se različiti postupci remedijacije voda onečišćenim SAS-ovima: napredni oksidacijski procesi, bioremedijacija te kombinacija navedenih postupaka. Najučinkovitiji postupak odabrat će se primjenom metodologije odlučivanja na temelju više kriterija nastojeći obuhvatiti najbolju učinkovitost uklanjanja i najveću financijsku isplativost postupka.]]></summary_hr><summary_en><![CDATA[Scientists around the world are currently focused on the impact of the SARS-CoV-2 virus on human health and on finding ways to prevent COVID -19 infection or at least alleviate the symptoms of infection. However, other impacts associated with COVID-19 also deserve in-depth study. We would like to highlight here the environmental impact of antivirals used to combat SARS-CoV-2. For most drugs, including antivirals, the human body metabolizes only 60-70% of the active ingredient. The residual metabolites and unmetabolized substances are excreted from the body and discharged into wastewater. Other potential sources of antivirals include hospital waste, wastewater from the pharmaceutical industry, and disposal of unused or outdated drugs. Unfortunately, it is well known that conventional wastewater treatment plants are not capable of effectively removing most of these substances. Therefore, many studies have confirmed the presence of antiviral substances in the aquatic environment, which pose a serious environmental risk. The fate and behavior of SARS-CoV-2 antiviral substances (SAS) in the aquatic environment are still relatively unknown. At the same time, the number of studies published to date on the removal of SAS from the environment is small. Therefore, the main objective of the EnA-SARS project is to investigate the fate and behavior of SAS in the environment, which is crucial for assessing the actual environmental risk. Therefore, an ecotoxicological risk assessment, including the investigation of possible synergistic effects, will be performed within the project. In addition, various processes for remediation of SAS-contaminated water will be investigated, including advanced oxidation processes, bioremediation, and a combination of the above. The most effective process will be selected by applying a multi-criteria decision-making considering the best removal efficiency and the highest cost-effectiveness of the process.]]></summary_en></project><project>
<id>18572</id><title_hr><![CDATA[Integrirani komunikacijski i senzorski sustavi usmjereni na ljudsko tijelo]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6686</user_id><user_firstLast_name>Zvonimir Šipuš</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-7817</code><acronim><![CDATA[BODYSEN]]></acronim><duration>03.03.2026 - 02.03.2032</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>873101</team_members_id><team_members_names><![CDATA[ Doktorand: Marko Smolić ]]></team_members_names><keywords_hr><![CDATA[senzorski sustavi, nosive antene, tekstilne antene, implantabilne antene, implantabilni senzori, pametna koža, metapovršine, daljinska detekcija]]></keywords_hr><keywords_en><![CDATA[sensor systems, wearable antennas, textile antennas, implantable antennas, implantable sensors, smart skin, metasurfaces, remote sensing]]></keywords_en><summary_hr><![CDATA[Jedan od glavnih izazova u razvoju komponenti za sustave usmjerene na ljudsko tijelo je dizajn uređaja koji može u isto vrijeme zadovoljiti tehničke uvjete i ispuniti netehničke zahtjeve. Na primjer, uređaji na ljudskom tijelu trebali bi biti estetski prihvatljivi i prikladni za nosive aplikacije, dok bi uređaji za implantaciju trebali biti volumno maleni i izrađeni od biološki prihvatljivih materijala. Različite primjene dovele su do mnogih otkrića u sustavima usmjerenim na tijelo u područjima zdravstvene skrbi, sporta, državne službe i zabave. Stoga je cilj projekta individualno razviti i naknadno integrirati različite uređaje za sustave usmjerene na tijelo i proširiti njihove komunikacijske i senzorske mogućnost primjenom novih tehnologija. Razmatrat će se svi elementi senzora i komunikacijskog sustava: u tijelu (kapsula senzora za implantaciju), na tijelu (nosivi pametni prsluk i pametna koža) i izvan tijela (antenski sustav temeljen na anteni s više glavnih latica za praćenje i komunikaciju u zatvorenom prostoru). Pri tome ćemo koristiti nove koncepte u dizajnu koji su nedavno predstavljeni, kao što su metapovršine, periodične strukture s višim simetrijama, tekstilne valovodne antene, implantabilne antene konstruirane prateći temeljna ograničenja te skeniranje optimizirano metodom strojnog učenja. Proces dizajna započet će analitičkim modeliranjem kanonskih slučajeva, realizacijom prototipova za dokaz koncepta i konačno razvojem komponenti prikladnih za integraciju u sustav usmjeren na ljudsko tijelo. To će omogućiti razvoj jedinstvenog sustava koji će imati potencijal pružanja opsežnih senzorskih informacija u stvarnom vremenu za više osoba ili objekata u različitim okruženjima. Dostizanjem konačnog cilja i demonstriranjem funkcionalnog višenamjenskog prototipa senzorskog i komunikacijskog sustava usmjerenog na ljudsko tijelo, imat ćemo platformu koja će imati potencijal biti okosnica u različitim biomedicinskim primjenama kao i u drugim industrijskim granama.]]></summary_hr><summary_en><![CDATA[One of the major challenges in the development of components for body-centric systems is to design a device that can at the same time satisfy technical requirements and fulfil non-technical requests. For example, on-body devices should be aesthetically acceptable and suitable for wearable applications, while implantable devices should be small and made of biologically acceptable materials. Various applications has led to many breakthroughs in body-centric systems focused on healthcare, fitness, civil services and entertainment. Therefore, the goal of the project is to individually develop and subsequently integrate different devices for body-centric systems and to extend their communication and sensing possibilities using new technologies. All elements of the sensor and communication system will be considered: in-body (implantable sensor capsule), on-body (wearable smart-vest and smart-skin) and off-body (multibeam antenna system for tracking and communication in indoor environment). In these developments we will use novel concepts which were recently introduced, such as metasurfaces, periodic structures with higher symmetry, textile waveguide antennas, implantable antennas designed by following fundamental limits on radiated power, and machine learning optimized scanning. The design process will start with analytic modelling of canonical cases, realization of proof-of-concept prototypes, and finally development of components suitable for integration into a body-centric system. This will allow development of a unified system which will have the potential to provide extensive real-time sensing information for multiple persons or objects in various environments. By reaching the final objective and demonstrating a functional multipurpose body-centric sensing and communication system prototype we will have a platform which will have potential to serve as backbone in various biomedical application fields and also in other industrial fields inspired by new applications.]]></summary_en></project><project>
<id>18573</id><title_hr><![CDATA[Termodinamički, spektroskopski i strukturni aspekti koordinacijskih reakcija kaliksarena]]></title_hr><title_en><![CDATA[]]></title_en><user_id>7690</user_id><user_firstLast_name>Vladislav Tomišić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-4658</code><acronim><![CDATA[CalixCORE]]></acronim><duration>13.01.2026 - 12.01.2032</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>873037</team_members_id><team_members_names><![CDATA[ Doktorand: Franka Sunjka ]]></team_members_names><keywords_hr><![CDATA[receptori, kaliksareni, inkluzijski kompleksi, supramolekulske kapsule i polimeri, termodinamika, solvatacija, hidrofobni efekt, fluorescencija]]></keywords_hr><keywords_en><![CDATA[receptors, calixarenes, inclusion complexes, supramolecular capsules and polymers, thermodynamics, solvation, hydrophobic effect, fluorescence]]></keywords_en><summary_hr><![CDATA[Efikasni i selektivni makrociklički receptori iona i neutralnih molekula odigrali su važnu ulogu u razvoju i primjeni supramolekulske kemije. Među njima posebno mjesto zauzimaju derivati kaliksarena na čiji će se dizajn, sintezu i fizikalno-kemijsku karakterizaciju usredotočiti ovaj projekt. Priredit će se niz derivata s različitim brojem funkcionaliziranih fenolnih podjedinica te se očekuje da će dobiveni spojevi imati velik afinitet za vezanje raznih monoatomnih i molekulskih iona i neutralnih vrsta. Jedan od ciljeva projekta je razviti iznimno osjetljive fluorescentne senzore. Pri tome će biti primijenjena naša nedavna saznanja vezana uz intrinzičnu fluorescenciju kaliksarena te će ta pojava biti detaljno istražena. Posebna će pažnja biti posvećena derivatima sa supstituentima koji ih čine zadovoljavajuće topljivima u vodi. Dio istraživanja bit će usmjeren k razvoju kaliksarenskih kapsula i polimera te na funkcionalizaciju površina komplementarnim kaliksarenskim derivatima. Detaljno će biti istražen utjecaj solvatacije na ravnoteže reakcija kompleksiranja, s naglaskom na inkluziju molekula otapala u hidrofobnu kaliksarensku šupljinu. S tim u vezi, ispitat će se receptorski potencijal kaliksarena za različite hidrofobne i (super)kaotropne vrste. Procesi kompleksiranja i solvatacije proučit će se sveobuhvatnim pristupom koji uključuje termodinamička, strukturna i računalna istraživanja. Koristit će se čitav niz eksperimentalnih (mikrokalorimetrija, fluorimetrija, UV-Vis i NMR spektroskopija, potenciometrija, konduktometrija, rentgenska strukturna analiza) i komputacijskih (simulacije molekulske dinamike, teorija funkcionala gustoće) metoda. Takav pristup omogućit će pouzdano određivanje termodinamičkih veličina (konstante stabilnosti, Gibbsove energije, entalpije i entropije kompleksiranja i otapanja) te strukturnih značajki receptora i njihovih kompleksa. Dobivene informacije pružit će detaljan uvid u ključne čimbenike koji određuju ishod proučavanih procesa.]]></summary_hr><summary_en><![CDATA[Efficient and selective macrocyclic receptors for ions and neutral molecules have played an important role in the development of supramolecular chemistry. Among the most important ones are calixarenes, which prompted us to devote research to the design, synthesis, and physicochemical characterization of these compounds and their complexation reactions. A series of derivatives with varying number of functionalized phenolic subunits will be prepared to obtain receptors with exceptional binding affinities towards monoatomic and molecular ions and neutral species. Some of these are aimed to be highly sensitive fluorescent sensors. With this respect, our recent findings regarding the intrinsic fluorescence of calixarenes will be implemented and this phenomenon will be studied in detail. Water-soluble derivatives and their binding abilities in aqueous medium will be especially addressed. An important objective will be development of calixarene capsules and polymers as well as functionalization of surfaces with complementary calixarenes. Particular attention will be paid to the solvation effects on binding reactions, with the emphasis on the inclusion of solvent molecules into the calixarene cavity. Furthermore, calixarene derivatives will be probed as potential receptors for various hydrophobic and (super)chaotropic compounds. Integrated thermodynamic, structural, and computational studies of complexation and solvation processes will be carried out. Several experimental (ITC, fluorimetry, UV-Vis and NMR spectroscopy, potentiometry, conductometry, X-ray diffraction) and computational (MD, DFT) methods will be employed. That will enable reliable determination of thermodynamic quantities (stability constants, reaction and solution Gibbs energies, enthalpies, and entropies) as well as structural characteristics of the receptors and their complexes. The obtained information will provide a detailed insight into the key factors determining the studied complexation equilibria.]]></summary_en></project><project>
<id>18580</id><title_hr><![CDATA[Značaj rijetkih varijanti gena imunološkog odgovora u istraživanju genetičke osnove multiple skleroze]]></title_hr><title_en><![CDATA[The Significance of Rare Immune Response Gene Variants in Advancing Knowledge of the Genetic Basis of Multiple Sclerosis]]></title_en><user_id>7505</user_id><user_firstLast_name>Nada Starčević Čizmarević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-1266</code><acronim><![CDATA[GENIMS]]></acronim><duration>26.01.2026 - 25.01.2029</duration><status>U tijeku</status><financ_value>191.400,00 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, Clinical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Medicine]]></institution_en><team_members_id>2819, 27280, 19607, 870699, 870596, 870885, 867797, 865310, 19660, 870229, </team_members_id><team_members_names><![CDATA[Alena Buretić-Tomljanović, Borut Peterlin, Valentino Rački, Ivana Stanković Matić, Aleksander Turk, Jasna Nekić, JADRANKA VRANEKOVIĆ, Lara Saftić Martinović, Sanja Dević Pavlić, Gloria Rožmarić, ]]></team_members_names><keywords_hr><![CDATA[Geni kandidati, Genska ekspresija, Imunološki putevi, Multipla skleroza, Multi-Omics, Rijetke genske varijante, Sekvenciranje egzoma]]></keywords_hr><keywords_en><![CDATA[Candidate genes, Exome sequencing, Gene expression, Immune pathways, Multi-Omics, Multiple sclerosis, Rare genetic variants]]></keywords_en><summary_hr><![CDATA[Multipla skleroza (MS) je kronična autoimuna neurodegenerativna bolest središnjeg živčanog sustava nejasne etiologije, unatoč potvrđenoj ulozi genetičke predispozicije i okolišnih čimbenika. MS je učestalija u žena, a prevalencija varira među geografskim regijama, pri čemu je Gorski kotar prepoznat kao područje visokog rizika. Genetičke studije identificirale su preko 230 MS rizičnih lokusa, no oni objašnjavaju samo dio nasljednosti bolesti. Sustav humanog leukocitnog antigena s HLA-DRB1*15:01 alelom, pokazao se najznačajnijim faktorom rizika, no velik dio genetičkog opterećenja, osobito u obiteljskim slučajevima i imunološkim putevima ostaje nepoznat.Predloženo istraživanje sekvenciranjem egzoma kroz inovativan pristup i integraciju bioinformatičkih analiza detektiralo bi rijetke varijante gena uključenih u imunološke puteve, posebice u obiteljskih slučajeva MS-a. Primjena tehnologije sekvenciranja sljedeće generacije u obiteljskih i  sporadičnih MS bolesnika te u bolesnika iz regije s visokom prevalencijom bolesti omogućit će identifikaciju rijetkih genskih varijanti s potencijalnom ulogom u nastanku bolesti. Analizom opterećenja ovih rijetkih varijanti može se procijeniti njihov kumulativni učinak u obiteljskim slučajevima te ukazati na ključnu ulogu u predispoziciji za MS. Bioinformatičke metode dodatno omogućuju analizu varijanti u imunološkim putevima, čime se stvara šira slika genetičkih mehanizama uključenih u patogenezu bolesti. Analizom ekspresije RNA validirat će se otkrivene rijetke potencijalno patogene, ali i učestale varijante gena te korelirati njihove učinke u podložnosti i tijeku bolesti uključujući autoimune komorbiditete.Očekuje se da će rezultati projekta pomoći u razumijevanju genetičkih čimbenika podložnosti za nastanak MS-a, posebno u kontekstu obiteljskih klastera bolesti. Povrh toga, projekt može poslužiti kao temelj za buduće studije genetičkih i imunoloških mehanizama kako u neurodegenerativnim tako i u drugim autoimunim bolestima.]]></summary_hr><summary_en><![CDATA[Multiple sclerosis (MS) is a chronic autoimmune neurodegenerative disease of the central nervous system with an unclear etiology, although genetic and environmental factors have been identified. MS is more prevalent in women, with incidence varying by geographic region; Gorski Kotar has been identified as a high-risk area. More than 230 susceptibility loci have been identified in genome-wide studies; however, these variants account for only a fraction of the disease heritability. The human leukocyte antigen and the HLA-DRB1*15:01 allele have been recognized as the strongest genetic risk factor. Nevertheless, a large part of the genetic burden remains unexplained, particularly in familial cases and immune-related pathways.In this study, exome sequencing is used to identify rare gene variants involved in immune pathways, particularly in familial MS, through an innovative approach and the integration of bioinformatic analyses.The application of next-generation sequencing technology to familial and sporadic MS cases, including high prevalence region, will allow the identification of rare gene variants that may play a role in the development of MS. Burden analysis will assess the cumulative impact of these variants, especially in familial cases where they may play a critical role in susceptibility to MS. Bioinformatic approaches allow for the systematic interrogation of variants within immune-related signalling pathways, providing a more comprehensive understanding of the genetic architecture underlying susceptibility to MS. RNA expression studies will validate rare and common variants and relate their effects to disease susceptibility, disease progression and associated autoimmune comorbidities.The results are expected to improve the understanding of genetic susceptibility to MS, particularly within familial clusters, and may provide a basis for future research into genetic and immunological mechanisms in neurodegenerative and autoimmune diseases.]]></summary_en></project><project>
<id>18582</id><title_hr><![CDATA[Evolucija kooperacije: Ekologija, ponašanje i srodstveni odnosi kod brašnara]]></title_hr><title_en><![CDATA[Evolution of cooperation: Ecology, behaviour and kin relationships in flour beetles]]></title_en><user_id>869905</user_id><user_firstLast_name>Barbara Milutinović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2025-02</proposal_call><code>UIP-2025-02-5457</code><acronim><![CDATA[ECO-KIN]]></acronim><duration>01.04.2026 - 31.03.2031</duration><status>U tijeku</status><financ_value>299.875,60 eur</financ_value><scie_area_hr>Prirodne znanosti, Interdiciplinarne znanosti, </scie_area_hr><scie_area_en>Natural sciences, Interdisciplinary scientific area, </scie_area_en><scie_field_hr>Biologija, Matematika, Kemija, </scie_field_hr><scie_field_en>Biology, Mathematics, Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>25587, 867515, 870294, 870278, 870174, </team_members_id><team_members_names><![CDATA[Antica Čulina, Jelena Bujan, Erik Frank, Ryosuke Iritani, Ana Korša, ]]></team_members_names><keywords_hr><![CDATA[Kooperacija, evolucija kooperacije, Hamiltonovo pravilo, infektivne bolesti, ponašanje životinja, Tribolium, kinoni, srodstvo, ekologija staništa]]></keywords_hr><keywords_en><![CDATA[Cooperation, evolution of cooperation, Hamilton’s rule, infectious disease, animal behaviour, Tribolium, quinones, kin discrimination, habitat ecology]]></keywords_en><summary_hr><![CDATA[Kooperacija je temelj društvenih interakcija, ona oblikuje uspjeh jedinki i potiče evoluciju biološke složenosti. Evolucijska teorija objašnjava kako se kooperacija razvija među srodnicima i nesrodnim jedinkama kada su evolucijske koristi veće od cijene pomaganja drugima. Ključno pitanje više nije zašto kooperacija evoluira, već kako—pod kojim uvjetima nastaje i koliko su njeni oblici raznoliki? Empirijska istraživanja ograničena su na nekoliko modelnih organizama, uglavnom ptice, ribe i mikroorganizme, pri čemu nisu svi prikladni za laboratorijske studije s velikim uzorkom. Također, manipulacija ravnoteže cijene i koristi kooperacije otežava empirijsko ispitivanje uvjeta u kojima se ona održava, raspada ili mijenja, primjerice pod pritiskom bolesti ili promjenama u srodstvu skupine.Ovaj projekt će uspostaviti brašnare (Tribolium) i njihove patogene kao novi model za proučavanje kooperacije, omogućujući preciznu kontrolu srodstva i cijene kooperacije putem rizika infekcije. Zarazne bolesti nude snažan, ali nedovoljno iskorišten alat za manipulaciju cijene kooperacije, budući da se infekcija i epidemiološki rizik mogu prilagoditi promjenom doze izlaganja i načina prijenosa, npr. putem zraka ili hrane, pri čemu je zadnji manje opasan. Kombinacijom infekcija, reproduktivnog učinka, analize ponašanja, i kemijskog prepoznavanja srodnika, projekt će istražiti kako pojedinci prilagođavaju kooperativna ponašanja u odnosu na srodstvo. Evolucijska stabilnost analizirat će se matematičkim modeliranjem. Osim toga, okolišni čimbenici također utječu na kooperaciju. Iako je Tribolium modelni organizam, malo se zna o njegovim ekološkim interakcijama. Ovaj projekt će prvi istražiti njihovo kopanje tunela i prostornu organizaciju, pružajući ekološki kontekst proučavanju kooperacije. Integrirajući ekologiju bolesti, kemijsku ekologiju i modeliranje, ovaj interdisciplinarni pristup pružit će nove uvide u evoluciju kooperacije i obrambene strategije od bolesti u životinjskim skupinama.]]></summary_hr><summary_en><![CDATA[Cooperation shapes social interactions, influencing individual success and driving the evolution of complex biological systems like multicellular organisms and insect societies. Evolutionary theory explains how cooperation emerges among kin and non-kin when fitness benefits outweigh personal costs. The key challenge is no longer why cooperation evolves, but how—what conditions favor it, and how diverse are its phenotypes? Current studies focus on a few model organisms, mainly birds, fish, and microbes, many of which are unsuitable for high-replication lab studies. Additionally, manipulating costs and benefits is difficult, limiting experimental tests of when cooperation persists, collapses, or shifts under ecological and social changes like disease pressure or group relatedness.This project will establish Tribolium beetles and their pathogens as a novel model for studying cooperation, allowing precise control over relatedness and costs via infection risk. Infectious disease is a powerful but overlooked tool for cost manipulation, as infection severity and transmission mode (airborne vs. foodborne) can be adjusted, with the latter being less harmful. Using infections, behavioral tracking, kin discrimination, and fitness assays, this project will investigate how individuals adjust cooperation under varying costs. Fitness effects will be assessed through mathematical modelling, providing a long-term perspective on evolutionary stability of found behaviours. Environmental factors also shape cooperation, yet little is known about Tribolium habitat interactions. This project will be the first to examine their tunnel-digging behavior and spatial organization, providing ecological context to cooperation. By integrating disease ecology, chemical ecology, and kin selection theory, this interdisciplinary approach will offer novel insights into cooperation and disease defense in animal groups.]]></summary_en></project><project>
<id>18587</id><title_hr><![CDATA[Između rata i mira. Transformacija kulturnog krajolika međuriječja Krke i Cetine od protohistorije do kasne antike]]></title_hr><title_en><![CDATA[]]></title_en><user_id>7512</user_id><user_firstLast_name>Domagoj Tončinić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-7966</code><acronim><![CDATA[TiHiTransForm]]></acronim><duration>15.01.2026 - 14.01.2032</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Arheologija, </scie_field_hr><scie_field_en>Archeology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>11234</team_members_id><team_members_names><![CDATA[ Doktorand: Jelena Lapić ]]></team_members_names><keywords_hr><![CDATA[rimska Dalmacija, transformacija kulturnog krajolika, daljinska istraživanja, rimska vojska, formiranje naselja, ekonomija, antika, rano kršćanstvo]]></keywords_hr><keywords_en><![CDATA[Roman Dalmatia, cultural landscape transformation, remote sensing, Roman military, settlement formation, economy, Antiquity, early Christianity]]></keywords_en><summary_hr><![CDATA[Glavni cilj projekta TiHiTransForm je utvrditi kako su i u kojoj mjeri potrebe za obranom i nadzorom prostora kroz nekoliko ključnih povijesnih procesa od protohistorije do kasne antike utjecale na transformaciju kulturnog krajolika međuriječja Krke i Cetine. Namjera projekta je istražiti odabrana potencijalna arheološka nalazišta koja nisu bila predmetom istraživanja prethodnog projekta AdriaRom (HRZZ-IP-2018-01-4934, voditelj: izv. prof. dr. sc. D. Tončinić). Ciljani prostor istraživanja projekta TiHiTransForm stoga će obuhvatiti ono područje koje je u okviru projekta AdriaRom snimljeno LiDAR-om, a to je prostor između Krke i Cetine. Hipoteza projekta TiHiTransForm je da su potrebe obrane i nadzora utjecale na transformaciju kulturnog krajolika međuriječja Krke i Cetine u razdoblju od protohistorije do kasne antike. S obzirom na cilj i hipotezu, formirana su sljedeća istraživačka pitanja:  IP1.) Koja je funkcija gradinskih položaja nakon uspostave rimske vlasti i tijekom kasne antike?; IP2.) Kako je podizanje rimskih vojnih logora na delmatskom limesu utjecalo na formiranje civilnih naselja (canabae, vici)?; IP3.) Kako gospodarske aktivnosti rimske vojske utječu na transformaciju kulturnog krajolika?; IP4.) Kako je odlazak rimske vojske utjecao na daljnji razvoj urbanih i ruralnih naselja civilnog karaktera, a s time i na nadzor nad prometom ljudi i roba?; IP5.) Kakav je odnos kasnoantičkih naselja i vila rustika s ranokršćanskim sakralnim građevinama?; IP6.) Koja je funkcija položaja nekadašnjih rimskih vojnih logora na delmatskom limesu tijekom kasne antike? Trenutačno stanje u temi istraživanja projekta TiHiTransForm, u kombinaciji s rezultatima dobivenim u okviru projekta AdriaRom, pokazuju da se implementacijom inovativne metodologije može odgovoriti na glavni cilj i hipotezu projekta TiHiTransForm. ]]></summary_hr><summary_en><![CDATA[The main goal of the TiHiTransForm project is to determine how and to what extent the need for defense and control through several key historical processes influenced transformation of the cultural landscape between the Krka and Cetina rivers from Protohistory to Late Antiquity. The project aims to investigate specific archaeological sites that were not the subject of research in the previous project AdriaRom (HRZZ-IP-2018-01-4934, PI: D. Tončinić, Ph.D.). The target research area of the TiHiTransForm project will cover the area that was scanned with LiDAR within AdriaRom project, i.e. the area between Krka and Cetina rivers. TiHiTransForm project hypothesizes that the need for defense and control influenced the transformation of the cultural landscape between the Krka and Cetina rivers in the period from Protohistory to Late Antiquity. Concerning the goal and hypothesis, the following research questions were formed: RQ1) What is the function of hillfort sites after the establishment of Roman rule and during Late Antiquity?; RQ2) How did the establishment of Roman military camps on the Delmataean limes affect the formation of civilian settlements?; RQ3) How did the economic activities of the Roman army affect the transformation of the cultural landscape?; RQ4) How did the departure of the Roman legions affect the further development of urban and rural settlements of civilian character, and with it the control over traffic of people and goods?; RQ5) What was the relationship between the Late Antique settlements and villae rusticae with the early Christian sacral buildings?; RQ6) What was the function of the former Roman military sites on the Delmataean Limes during the Late Antiquity? The current state of research on the topic of the TiHiTransForm project, combined with the results obtained within the AdriaRom project, show that the implementation of this innovative methodology can answer the main goal and hypothesis of the TiHiTransForm project.]]></summary_en></project><project>
<id>18588</id><title_hr><![CDATA[Klimatske migracije u obrazovanju: Inovativni nastavni mediji za razumijevanje intersekcionalnih kriza]]></title_hr><title_en><![CDATA[Climate Migration in Education: Innovative Educational Media for Understanding Intersectional Crises]]></title_en><user_id>870741</user_id><user_firstLast_name>Mirela Holy</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-5454</code><acronim><![CDATA[KlimEd]]></acronim><duration>15.01.2026 - 14.01.2029</duration><status>U tijeku</status><financ_value>160.000,00 eur</financ_value><scie_area_hr>Društvene znanosti, Interdiciplinarne znanosti, Prirodne znanosti, </scie_area_hr><scie_area_en>Social sciences, Interdisciplinary scientific area, Natural sciences, </scie_area_en><scie_field_hr>Interdisciplinarne društvene znanosti, Biologija, Informacijske znanosti, Sociologija, Pedagogija, Obrazovne znanosti, </scie_field_hr><scie_field_en>Interdisciplinary social sciences, Biology, Information sciences, Sociology, Pedagogy, Educational sciences, </scie_field_en><institution_hr><![CDATA[Ništa od navedenog]]></institution_hr><institution_en><![CDATA[Nothing from this list]]></institution_en><team_members_id>6999, 190, 868577, 500, 20501, 870087, 867014, </team_members_id><team_members_names><![CDATA[Marija Geiger Zeman, Ivan Balabanić, Kristina Posavec, Marko Turk, Irena Martinović Klarić, Dubravka Petrović Štefanac, Marek Mikuš, ]]></team_members_names><keywords_hr><![CDATA[klimatske promjene, migracije, klimatske migracije, održivi razvoj, poučavanje o intersekcionalnim krizama, inovativni nastavni mediji]]></keywords_hr><keywords_en><![CDATA[climate change, migration, climate migration, sustainable development, intersectional crisis communication, innovative educational media]]></keywords_en><summary_hr><![CDATA[Projekt „Klimatske migracije u obrazovanju: Inovativni nastavni mediji za razumijevanje intersekcionalnih kriza“ bavi se istraživanjem načina na koji nastavnici u osnovnim i srednjim školama u Hrvatskoj poučavaju učenike o globalnim intersekcionalnim krizama, preciznije o klimatskim promjenama i migracijama, s posebnim naglaskom na klimatske migracije. Istraživanje se temelji na pretpostavci da školski sustav ima ključnu ulogu u oblikovanju stavova i svijesti učenika o ovim složenim temama, no nedostatak edukativnih resursa i prilagođenih pristupa može ograničiti kapacitet nastavnika za učinkovitu komunikaciju ovih tema.Korištenjem kvantitativnih i kvalitativnih istraživačkih metoda, projekt će ispitati: 1) Na koji način nastavnici osnovnih i srednjih škola u RH razumijevaju obrazovanje o intersekcionalnim krizama te koji je spektar njihovih mišljenja i informiranosti o ovoj temi? 2) Na koji način i s kojim sadržajima je moguće unaprijediti kurikule viših razreda osnovne škole te srednjih škola o intersekcionalnim krizama? 3) Kako obrazovne sadržaje učiniti interaktivnima i razumljivima za poučavanje uz korištenje inovativnih alata (infografika, video igara, memova, kratkih dokumentarnih videa) koji će učinkovito potaknuti kritičko razmišljanje, razumijevanje i angažman učenika o intersekcionalnim krizama?Rezultati istraživanja omogućit će detaljan uvid u trenutne nastavne prakse i izazove u poučavanju ovih tema, te pružiti preporuke za razvoj inovativnih i inkluzivnih nastavnih medija o ovim gorućim temama. Očekuje se da će projekt doprinijeti unaprjeđenju kurikuluma i podržati nastavnike u jačanju svijesti mladih o ključnim globalnim problemima kroz kritičko i interdisciplinarno obrazovanje.]]></summary_hr><summary_en><![CDATA[The project &#39;&#39;Climate Migration in Education: Innovative Educational Media for Understanding Intersectional Crises&#39;&#39; explores how primary and secondary school teachers in Croatia educate students about global intersectional crises, particularly climate change and migration, with a special emphasis on climate migration. The research is based on the assumption that the educational system plays a crucial role in shaping students&#39; attitudes and awareness of these complex issues. However, a lack of educational resources and tailored approaches may limit teachers&#39; capacity to effectively communicate these topics.Using both quantitative and qualitative research methods, the project will investigate: 1) How do primary and secondary school teachers in Croatia understand education about intersectional crises, and what is the spectrum of their opinions and awareness regarding this topic? 2) How and with what content can curricula for upper primary and secondary schools be improved concerning intersectional crises? 3) How can educational content be made interactive and accessible by utilizing innovative tools (infographics, video games, memes, short documentary videos) that effectively foster critical thinking, understanding, and student engagement about intersectional crises?The research outcomes will provide detailed insights into current teaching practices and challenges in addressing these topics, and offer recommendations for developing innovative and inclusive teaching media on these pressing issues. It is anticipated that the project will contribute to curriculum enhancement and support teachers in raising young people&#39;s awareness of crucial global problems through critical and interdisciplinary education.]]></summary_en></project><project>
<id>18592</id><title_hr><![CDATA[Skaliranje u stohastičkim modelima]]></title_hr><title_en><![CDATA[]]></title_en><user_id>279</user_id><user_firstLast_name>Nenad Šuvak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-9144</code><acronim><![CDATA[SCALISM]]></acronim><duration>15.10.2025 - 14.10.2031</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Fakultet primijenjene matematike i informatike]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, School of Applied Mathematics and Informatics]]></institution_en><team_members_id>872874</team_members_id><team_members_names><![CDATA[ Doktorand: Sven Dukić ]]></team_members_names><keywords_hr><![CDATA[Slučajni procesi, svojstva skaliranja, superpozicije procesa, granični teoremi, difuzije, skaliranje vremena procesa, multifraktalnost, EEG signali]]></keywords_hr><keywords_en><![CDATA[Stochastic processes, scaling properties, superpositions of processes, limit theorems, diffusions, scaling of time, multifractality, EEG signals]]></keywords_en><summary_hr><![CDATA[Stohastički modeli od ključne su važnosti u opisivanju brojnih fenomena u raznim područjima znanosti i života. Bitno svojstvo vremenski ovisnih modela je njihovo ponašanje u odnosu na promjenu vremenske odnosno prostorne skale. Karakteristike brojnih fenomena mogu se značajno mijenjati promjenom skale. Primjerice, u svijetu čestica vladaju potpuno drugačiji prirodni zakoni od onih na astronomskim skalama. Potreba za modelima sa specifičnim svojstvima skaliranja dolazi iz brojnih praktičnih primjena u medicini, biologiji, fizici, financijama, ekonomiji i drugim područjima znanosti. Cilj projekta je konstrukcija i proučavanje stohastičkih modela s posebnim svojstvima skaliranja. Poseban naglasak je na proučavanju svojstva modela na granično malim ili velikim skalama. Između ostalog, ponudit će se objašnjenje fenomena vezanog uz skaliranje empirijskih momenata koji je poznat kao Taylorov zakon. Konstruirat će se i analizirati nove klase slučajnih procesa dobivene zamjenom vremenske skale nekih standardnih procesa. Razvijeni modeli primijenit će se u epidemiologiji i analizi EEG signala te će se razviti model za klasifikaciju neurokognitivnih ishoda na osnovu parametara skaliranja.]]></summary_hr><summary_en><![CDATA[Stochastic models are of great importance in describing numerous phenomena in various fields of science and life. An essential property of time-dependent models is their behavior under time and space scaling. The characteristics of many phenomena can be significantly changed by changing the scale. For example, as we move from the tiny world of particles to the astronomical scales, the laws of nature may behave drastically different. The need for models with specific scaling properties comes from numerous practical applications in medicine, biology, physics, finance, economics and other fields of science. The goal of the project is the construction and investigation of stochastic models with special scaling properties. The emphasis is placed on the study of properties of models in the limits of small or large scales. Among other results, a possible explanation will be provided for the phenomenon related to the scaling of empirical moments, known as Taylor&#39;s law. By replacing the time scale of some standard processes, the new classes of stochastic processes will be constructed and analyzed. These new models will be applied in epidemiology and EEG signal analysis. Furthermore, model for the classification of neurocognitive outcomes based on scaling parameters will be developed.]]></summary_en></project><project>
<id>18594</id><title_hr><![CDATA[Potresna otpornost građevina kulturne baštine: višerazinsko numeričko modeliranje i strategije očuvanja]]></title_hr><title_en><![CDATA[Seismic Resilience of Built Cultural Heritage: Multi-Scale Numerical Modeling and Preservation Strategies]]></title_en><user_id>13076</user_id><user_firstLast_name>Marija Demšić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2025-02</proposal_call><code>UIP-2025-02-8638</code><acronim><![CDATA[SHiRe]]></acronim><duration>01.04.2026 - 31.03.2031</duration><status>U tijeku</status><financ_value>289.853,50 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Građevinarstvo, Arhitektura i urbanizam, Temeljne tehničke znanosti, </scie_field_hr><scie_field_en>Civil engineering, Architecture and Urban Environment, Basic engineering sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Građevinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Civil Engineering]]></institution_en><team_members_id>13267, 21063, 870005, </team_members_id><team_members_names><![CDATA[Petra Gidak, Elizabeta Šamec, Igor Tomić, ]]></team_members_names><keywords_hr><![CDATA[povijesne građevine, povijesno-umjetnički elementi, numerička analiza, potres, razine oštećenja, mjere ojačanja]]></keywords_hr><keywords_en><![CDATA[historical buildings, heritage art elements, numerical analysis, earthquake, damage levels, strengthening measures]]></keywords_en><summary_hr><![CDATA[Očuvanje povijesnih građevina kulturne baštine koja je danas izložena višestrukim rizicima predstavlja jedan od važnih zadataka i izazova koji su postali zajednička odgovornost međunarodnih organizacija, nacionalnih tijela, te stručnjaka iz više područja i šire zajednice. Svakako, jedan od kritičnih rizika, koji može dovesti i do potpunog uništenja kulturne baštine je djelovanje potresa. Republika Hrvatska posjeduje pravo bogatstvo građevina koje se kvalificiraju pod naziv kulturna baština, a mnoge su smještene u područja visoke seizmičnosti. Nadalje, očuvanje građevina kulturne baštine ne treba gledati samo u kontekstu potresne oštetljivosti konstrukcijskih elemenata nego je nužno dati dovoljnu pozornost svim segmentima povijesno-umjetničke vrijednosti koji su podložni oštećenjima. Takvi elementi i za potrese nižih intenziteta mogu zadobiti oštećenja koja će znatno narušiti izvorne baštinske vrijednosti. Stoga je jedan od bitnih ciljeva predloženog znanstveno-istraživačkog projekta usmjeren na definiciju kriterija za razine oštećenja povijesnih građevina kulturne baštine sukladno njihovoj tipologiji, a koji se temelje na oštećenju pojedinih konstrukcijskih elemenata te povijesno-umjetničkih elemenata vrednujući njihove baštinske vrijednosti. U istraživanju će se iskoristiti sve prednosti naprednog numeričkog modeliranja, pri čemu će se provesti parametarske analize modela različite složenosti kako bi se kvantificirale razine oštećenja te razvile optimizirane strategije ojačanja. Dodana vrijednost ovog pristupa je i u kalibraciji modela različite složenosti kako bi se rezultati parametarskih analiza detaljnih modela mogli primijeniti na manje zahtjevnim numeričkim modelima. U sklopu istraživanja razvit će se i metodologija ciljanih ojačanja konstrukcije u skladu sa smjernicama za očuvanje građevina kulturne baštine prema ISCARSAH-ICOMOS smjernicama.]]></summary_hr><summary_en><![CDATA[The preservation of historic buildings, which are part of the cultural heritage exposed to multiple risks today, is one of the important tasks and challenges that have become a shared responsibility of international organisations, national institutions, experts from different fields and society. One of the risks that can lead to the complete destruction of built cultural heritage is the impact of earthquakes. The Republic of Croatia has a wealth of cultural heritage buildings, many of which are located in areas of high seismic activity. Furthermore, the preservation of cultural heritage buildings should not only be seen in the context of the seismic vulnerability of the structural elements; it is important to pay appropriate attention to all aspects of historical and artistic value that are susceptible to damage. Such elements can suffer damage even during low-intensity earthquakes, significantly affecting their authentic value as cultural heritage. One of the main objectives of the scientific research project is therefore to define criteria for the levels of damage to historic cultural heritage buildings depending on their typology. These criteria will be based on the level of damage of specific structural elements and non-structural historical and artistic elements by also considering their heritage value. The research will leverage the advantages of advanced numerical modelling by performing parametric analyses of models of varying complexity to quantify the level of damage and develop optimized strengthening strategies. An additional benefit of this approach is the calibration of models of varying complexity, ensuring that the results of parametric analyses of detailed models can be applied to less demanding numerical approaches. The research will also develop a methodology for targeted structural strengthening in accordance with the Guidelines for the Conservation of Cultural Heritage Buildings, which follow the recommendations of ISCARSAH-ICOMOS.]]></summary_en></project><project>
<id>18596</id><title_hr><![CDATA[Kognitivne sposobnosti mladih sportaša: ključ uspjeha u sportu ]]></title_hr><title_en><![CDATA[Cognitive abilities of youth athletes: the key to success in sports]]></title_en><user_id>19211</user_id><user_firstLast_name>Tea Galic</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-4162</code><acronim><![CDATA[KoSMoS]]></acronim><duration>01.12.2025 - 30.11.2028</duration><status>U tijeku</status><financ_value>147.195,31 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo, Društvene znanosti, </scie_area_hr><scie_area_en>Biomedicine and health sciences, Social sciences, </scie_area_en><scie_field_hr>Kognitivna znanost, Kliničke medicinske znanosti, Dentalna medicina, Psihologija, Kineziologija, </scie_field_hr><scie_field_en>Cognitive science, Clinical sciences, Dental medicine, Psychology, Kinesiology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Split School of Medicine]]></institution_en><team_members_id>3198, 864919, 868601, 866553, 865149, 4543, 25405, 868607, 868620, 868618, 868609, 147, 433, </team_members_id><team_members_names><![CDATA[Dinko  Pivalica, Frane Mihanović, Neven Kovačević, Tatjana Matijaš Matijaš, Vladimir Pavlinović, Linda Lušić Kalcina, Nikola Foretić, Marko Herceg, Nikolina Lešić, Davor Seifert, Božen Pivalica, Damir Sekulić, Ognjen Uljević, ]]></team_members_names><keywords_hr><![CDATA[kognitivne sposobnosti, psihomotorna brzina, inhibicija, sport, ozljede, kognitivni trening]]></keywords_hr><keywords_en><![CDATA[cognitive abilities, psychomotor speed, inhibition, sports, injuries, cognitive training]]></keywords_en><summary_hr><![CDATA[Sudjelovanje u sportskim aktivnostima u dječjoj dobi povezano je s poboljšanjem kognitivnih funkcija. Dokazano je da igrači timskih sportskih igara imaju bolje izvršne funkcije u odnosu na igrače iz drugih sportova jer trebaju brzo procesuirati informacije iz okoline s obzirom na poziciju suigrača i smjer kretanja lopte. Jedan od takvih sportova je vaterpolo, vrlo zahtjevan kontaktni sport koji uz dobre funkcionalne i motoričke sposobnosti od igrača traži i dobro razvijenu percepciju, anticipaciju, pravovremeno donošenje odluke za vrijeme igre i brzu reakciju. Odabran je za ovaj projekt kao sport koji u mladih sportaša razvija fizičke, perceptivne i kognitivne sposobnosti, a literatura o povezanosti kognitivnih funkcija i razvoja mladih vaterpolista je ograničena. U našim dosadašnjim publikacijama pokazali smo da djeca školske dobi koja se bave vaterpolom pokazuju bolje izvršne funkcije u usporedbi s djecom iste dobi koja se ne bave organiziranim sportskim aktivnostima. U našem daljnjem znanstvenom radu usporedit ćemo kognitivne funkcije mladih vaterpolista muškog i ženskog spola s djecom koja se bave drugim timskim kontaktnim sportovima s loptom (nogomet, rukomet, košarka) i individualnim sportovima (tenis, plivanje, taekwondo). Drugi cilj ovog dijela projekta je ispitati utjecaj kognitivnog treninga u mladih igrača vaterpola na psihomotornu brzinu korištenjem platforme Blaze Pod. Treći cilj je istražiti učestalost ozljeda u mladih sportaša muškog i ženskog spola te ispitati postoji li korelacija između tih rezultata i rezultata testiranja kognitivnih funkcija, osobito psihomotorne brzine i inhibicije. Rezultati ovog projekta mogu pomoći trenerima, sportskim djelatnicima, ali i roditeljima da pravilno odaberu sport, s obzirom na fizičke i mentalne potencijale djeca, kao i pri odabiru igrača za pojedine igračke pozicije ili u selekciji za nacionalne reprezentacije u različitim sportovima.]]></summary_hr><summary_en><![CDATA[Children’s engagement in sports, independent of their age, has been associated with the improvement of cognitive functions. It has been shown that players in team contact ball sports show better executive function compared to players from other sports because they need to process real-time actions with regard to teammate positions and ball path. Water polo, as one of those sports, is a highly demanding contact team sport requiring well-developed functional and motor skills, as well as perception, anticipation, problem solving and decision making, inhibition and fast reaction time. It has been chosen in this study because it challenges physical, perceptual and cognitive performance and the literature on the association of the cognitive performance and development of youth water polo players is limited. In our previous research it has been shown that youth water polo players showed a better performance in psychomotor speed, response inhibition and motor speed than school children not participating in organized sports activity. In this project we will compare cognitive functions of youth water polo players, male and female, with youth athletes participating in other team contact ball sports (soccer, handball, basketball) and individual sports (tennis, taekwondo, swimming). The second aim of this project is to examine the efficiency of cognitive training using Blaze Pod platform in youth water polo players during their regular training program. Third aim of this project is to assess the incidence of sports-related injuries and its correlation with cognitive functions, specifically psychomotor speed and inhibition, in youth athletes, males and females. Results of this project might be useful for coaches and sports professionals, as well as parents, to choose the proper sport activity according to child&#39;s physical and mental potentials, as well as for the selection of youth athletes for national teams in different sports or the specific playing positions in the game.]]></summary_en></project><project>
<id>18597</id><title_hr><![CDATA[Nutritivna vrijednost mladih listova domaćeg maka u kontekstu urbane funkcionalne hrane]]></title_hr><title_en><![CDATA[Nutritive Profile of „Baby Leaf“ Domestic Poppy in the Context  of Urban Functional Food]]></title_en><user_id>11148</user_id><user_firstLast_name>Ivana Varga</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2025-02</proposal_call><code>UIP-2025-02-9916</code><acronim><![CDATA[BabyPOP]]></acronim><duration>19.02.2026 - 18.02.2031</duration><status>U tijeku</status><financ_value>228.090,00 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, Prehrambena tehnologija, </scie_field_hr><scie_field_en>Agriculture, Food technology, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Fakultet agrobiotehničkih znanosti Osijek]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Agrobiotechnical Sciences in Osijek]]></institution_en><team_members_id>25001, 855872, 28910, 19497, 23751, 4241, </team_members_id><team_members_names><![CDATA[Sanja Grubišić Šestanj, Dejan Bošnjak, Boris Ravnjak, Željka Kuharić, Monika Tkalec Kojić, Mario Franić, ]]></team_members_names><keywords_hr><![CDATA[Papaver somniferum L., bioaktivne komponente, genotipizacija, hidropon, in vitro, prinos]]></keywords_hr><keywords_en><![CDATA[Papaver somniferum L., bioactive component, genotyping, hidroponics, in vitro, yield]]></keywords_en><summary_hr><![CDATA[Domaći mak (Papaver somniferum L.) uglavnom se uzgaja zbog sjemena, osobito u Srednjoj i Istočnoj Europi. Poznat je i po ljekovitim svojstvima, a zbog sastava alkaloida, proizvodnja je zakonski regulirana u većini zemalja EU. Proizvodnja nutritivno vrijedne hrane u hidroponiji predstavlja inovativnu metodu uzgoja biljaka bez upotrebe tla, koristeći hranjive otopine za opskrbu biljaka svim potrebnim nutrijentima. Kroz takav sustav  optimizira se iskorištavanje prostora, vode i hranjiva, a omogućava se proizvodnja  visokokvalitetne hrane tijekom cijele godine. U svijetu rapidno raste interes za proizvodnjom i upotrebom mladih izdanaka biljaka, uprvo zbog njihove nutritivne vrijednosti, ali i pozitivnom utjecaju na ljudsko zdravlje. Proizvodnja maldih listova maka otvara novo područje upotrebe i tehnologije proizvodnje maka.]]></summary_hr><summary_en><![CDATA[Domestic poppy (Papaver somniferum L.) is mainly cultivated for its seeds, especially in Central and Eastern Europe, and its production is legally regulated in the EU due to opium alkaloids. Interest in the production of poppies is growing in Croatia. Globally, the demand for young plant shoots (baby leaves) is growing due to their nutritional value and functional properties. The aim of this project is the establishment of the production technology of baby leaf poppy in the floating hydroponics system. Such a system enables faster growth, optimization of resources, and production of fast-growing super food throughout the whole year. The other aim of the project is the genotyping of the local poppy population and development of the methodology for the analysis of biologically active compounds, nutritional composition, and antioxidant activity of baby leaf poppy. The project will optimize the production process of young poppy leaves as a fast-growing super food. According to the available literature, this is the first research that deals with the technology of producing young poppy leaves for salad, which opens up a completely new field of poppy utilization and encourages the revitalization of this culture in Croatia and beyond.]]></summary_en></project><project>
<id>18598</id><title_hr><![CDATA[Računalni vid u detekciji plodova i procjeni uroda maslina]]></title_hr><title_en><![CDATA[]]></title_en><user_id>7703</user_id><user_firstLast_name>Vladan Papić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-7990</code><acronim><![CDATA[CoViO]]></acronim><duration>01.02.2026 - 31.01.2032</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Fakultet elektrotehnike, strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Electrical Engineering, Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>873078</team_members_id><team_members_names><![CDATA[ Doktorand: Ana Šarić Gudelj ]]></team_members_names><keywords_hr><![CDATA[maslinarstvo, računalni vid, duboke neuronske mreže, obrada slika, bespilotne letjelice]]></keywords_hr><keywords_en><![CDATA[olive growing, computer vision, deep neural networks, image processing, unmanned aerial vehicles]]></keywords_en><summary_hr><![CDATA[U okviru ovog projekta istraživanja će se fokusirati na uvođenje novih tehnologija i umjetne inteligencije u maslinarstvu. Prvi pravac istraživanja odnosi se na razvoj procedura i algoritama za analizu slika stabala masline a s ciljem detekcije plodova. Ovo je posebno izazovan zadatak jer se namjerava razviti postupak koji će omogućiti detekciju plodova i u ranim fazama razvoja kada su plodovi malih dimenzija. Drugi pravac istraživanja odnosi se na razvoj algoritama za procjenu zrelosti plodova te ukupnog uroda. Osnovna hipoteza je da se može razviti procedura koja će omogućiti da se iz snimki maslinika bespilotnom letjelicom dobije kvalitetna informacija o stanju plodova i procijeni urod. U ovom dijelu istražit će se i korelacija između intenziteta cvatnje sa konačnim rezultatima uroda. Tijekom istraživanja očekuje se formiranje referentne i javno dostupne baze označenih slika za učenje (različita doba dana i godine, različiti vremenski uvjeti). Postupci i algoritmi predobrade i obrade slika biti će prilagođeni za uspješan rad na slikama prikupljenim bespilotnom letjelicom te pod znatno manjim ograničenjima od pristupa do sada dostupnih u literaturi. Ispitat će se moguće poboljšanje kvalitete ulaznih podataka, a posljedično i rezultata kombiniranjem informacije dobivene s RGB i multispektralnog senzora. Osim toga, predložit će se i optimizirana arhitektura temeljena na dubokim neuronskim mrežama s ciljem izbjegavanja kompleksnosti i omogućavanja njene implementacije na manje zahtjevnim računalnim resursima.]]></summary_hr><summary_en><![CDATA[In this project, research w ill be focused towards introduction of new technologies and artificial intelligence in olive growing. First research direction is related to development of procedures and algorithms for olive trees analysis in order to detect olive fruits. This is especially challenging because intention is to develop a procedure that w ill enable detection of olive fruits in early stages of development w hen they are small. Second research direction is related to development of algorithms for estimation of fruit maturity and complete yield. Main hypothesis is that it is possible to develop a procedure that w ill enable quality information on fruits state and yield estimate based on olivegroves images taken with an unmanned aerial vehicle. In this part, correlation between flowering intensity and yield will be investigated. During research, forming of an reference and publicly available labeled images database is expected (various time of day and seasons, various weather conditions). Procedures and algorithms for image preprocessing will be adopted for successful implementation on images collected with a drone and also to work on less constrains then approaches presented in the literature. Investigation of possible quality improvement of input data and, consequently, also the final results based on combination of information obtained RGB and multispectral sensors. Moreover, optimized architecture based on deep neural networks will be proposed in order to lower complexity and allow implementation on less demanding hardware.]]></summary_en></project><project>
<id>18600</id><title_hr><![CDATA[Algoritamski poduzetnički proces: preoblikovanje dominantne paradigme]]></title_hr><title_en><![CDATA[The Algorithmic Entrepreneurial Process: Reshaping the Dominant Paradigm]]></title_en><user_id>2577</user_id><user_firstLast_name>Robert Kudelić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2025-02</proposal_call><code>UIP-2025-02-7375</code><acronim><![CDATA[AGENT]]></acronim><duration>19.02.2026 - 18.02.2031</duration><status>U tijeku</status><financ_value>201.632,95 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Informacijske znanosti, Ekonomija, Informacijske znanosti, </scie_field_hr><scie_field_en>Information sciences, Economy, Information sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet organizacije i informatike]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Organization and Informatics]]></institution_en><team_members_id>870147, 6796, 861620, 870816, </team_members_id><team_members_names><![CDATA[Maja Cerjan, Mladen Turuk, Tamara Šmaguc, Ana Novak, ]]></team_members_names><keywords_hr><![CDATA[algoritamsko poduzetništvo, kvantno računalstvo, poduzetnički proces, umjetna inteligencija, teorija složenosti]]></keywords_hr><keywords_en><![CDATA[algorithmic entrepreneurship, quantum computing, entrepreneurial process, artificial intelligence, complexity theory]]></keywords_en><summary_hr><![CDATA[Istraživanjem tragamo za odgovorom na pitanje kako algoritmi kvantnog računalstva i umjetne inteligencije mogu djelovati kao omogućavatelji generiranja poduzetničkih rezultata u početnim fazama poduzetničkog procesa. Ciljevi istraživanja su sljedeći: C1: definirati algoritamsko poduzetništvo i razviti konceptualni okvir za algoritamsko poduzetništvo te time pružiti polazište za daljnje znanstveno utemeljenje fenomena, C2: ispitati i identificirati skup aktivnosti i posljedično niz koraka u početnim fazama poduzetničkog procesa koji su potencijalno algoritamski rješivi i relevantni za rješavanje (uz potencijalna ograničenja), C3: unutar definiranog skupa potencijalno algoritamski rješivih problema izvesti algoritamske definicije istih, C4: za izvedene algoritamske definicije problema potencijalno pogodnih za rješavanje s pomoću algoritama kvantnog računalstva metodom svođenja problema klase kompleksnosti identificirati barem jedan problem koji zahtjeva računalnu snagu kvantnog računala, C5: barem jedan od problema koji zahtjeva računalnu snagu kvantnog računala riješiti razvojem algoritma kvantnog računalstva, C6: razviti rješenje softverskog robota/agenta za razgovaranje koji će omogućiti korištenje rezultata istraživanja unutar okvira intuitivne digitalne tehnologije. U istraživanju će se koristiti sljedeće metode i postupci: (1) sistematizirani pregled literature; (2) opservacijska studija slučaja; (3) kvalitativno istraživanje primjenom tehnike fokusne grupe; (4) pretraživanje literature i komparativna analiza radi identifikacije problema koji su prikladni za rješavanje putem kvantnog računala; (5) metoda svođenja (redukcija) problema klase kompleksnosti, a radi identifikacije barem jednog poduzetničkog problema koji zahtjeva računalnu snagu kvantnog računala; (6) razvoj kvantnog algoritma; (7) modeliranje aplikativnog rješenja putem UML-a i razvoj prototipa softverskog agenta.]]></summary_hr><summary_en><![CDATA[The research seeks to answer the question of how quantum computing and artificial intelligence algorithms can act as enablers of generating entrepreneurial results in the initial stages of the entrepreneurial process. The research objectives are as follows: C1: to define algorithmic entrepreneurship and develop a conceptual framework for algorithmic entrepreneurship, thereby providing a starting point for further scientific foundation of the phenomenon, C2: to examine and identify a set of activities and consequently a series of steps in the initial stages of the entrepreneurial process that are potentially algorithmically solvable and relevant for solving (with potential limitations), C3: within a defined set of potentially algorithmically solvable problems, derive algorithmic definitions of the problems, C4: for the derived algorithmic definitions of problems potentially suitable for solving using quantum computing algorithms, to identify at least one problem that requires the computing power of a quantum computer using the method of reducing problems of the complexity class, C5: to solve at least one of the problems that require the computing power of a quantum computer by developing a quantum computing algorithm, C6: to create a chatbot solution that will enable the use of the research results within the framework of intuitive digital technology. The following methods and procedures will be used in the research: (1) a systematic literature review; (2) an observational case study; (3) qualitative research using the focus group technique; (4) a literature search and comparative analysis to identify problems that are suitable for solving using a quantum computer; (5) a method of reducing problems of a complexity class to identify at least one entrepreneurship problem that requires the computing power of a quantum computer; (6) development of a quantum algorithm; (7) modeling of an application solution using UML and development of a prototype of software agent.]]></summary_en></project><project>
<id>18601</id><title_hr><![CDATA[Understanding, predicting, and treating depression in pregnancy to improve mothers and offspring mental health outcomes (HappyMums)]]></title_hr><title_en><![CDATA[]]></title_en><user_id>19126</user_id><user_firstLast_name>Sandra Nakić Radoš</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-2987</code><acronim><![CDATA[]]></acronim><duration>08.12.2025 - 07.12.2031</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Psihologija, </scie_field_hr><scie_field_en>Psychology, </scie_field_en><institution_hr><![CDATA[Hrvatsko katoličko sveučilište, Zagreb]]></institution_hr><institution_en><![CDATA[Catholic University of Croatia]]></institution_en><team_members_id>872978</team_members_id><team_members_names><![CDATA[ Doktorand: Nikolina Vukšić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>18603</id><title_hr><![CDATA[Transport, metastability, and neuromorphic applications in quantum networks (QNet), QuantERA2023 projekt]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5410</user_id><user_firstLast_name>Ticijana Ban</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-8415</code><acronim><![CDATA[]]></acronim><duration>13.10.2025 - 12.10.2030</duration><status>U tijeku</status><financ_value>60,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut za fiziku]]></institution_hr><institution_en><![CDATA[Institute of Physics in Zagreb]]></institution_en><team_members_id>872866</team_members_id><team_members_names><![CDATA[ Doktorand: Juraj Gajović ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>18611</id><title_hr><![CDATA[Pelud u Jadranskom moru: dinamika unosa, kemijska karakterizacija i utjecaj na primarnu produkciju]]></title_hr><title_en><![CDATA[]]></title_en><user_id>106</user_id><user_firstLast_name>Slađana Strmečki Kos</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-8191</code><acronim><![CDATA[POLLMAR]]></acronim><duration>09.12.2025 - 08.12.2030</duration><status>U tijeku</status><financ_value>60,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Interdisciplinarne prirodne znanosti, </scie_field_hr><scie_field_en>Interdisciplinary natural sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>872981</team_members_id><team_members_names><![CDATA[ Doktorand: Terezija Galeković ]]></team_members_names><keywords_hr><![CDATA[Pelud, atmosfersko taloženje, površinski slojevi morske vode, peludni organski materijal, fitoplanktonska produkcija.]]></keywords_hr><keywords_en><![CDATA[Pollen, atmospheric deposition, surface seawater layers, subpollen organic material, phytoplankton production.]]></keywords_en><summary_hr><![CDATA[Scenariji budućih klimatskih promjena predviđaju da će se koncentracije peludi u zraku povećati jer se vrijeme oprašivanja biljaka produljuje zbog povećanih koncentracija CO2 u atmosferi i viših temperatura. Interakcije kopna i mora postat će intenzivnije, a budući da pelud sadrži značajnu količinu organskih hranjivih tvari, jedan je od alohtonih unosa u prirodne vode koji može promijeniti dinamiku ekosustava. Iako je unos peludi u slatkovodne sustave (osobito jezera) vrlo dobro proučen, nema informacija o utjecaju unosa peludi na primarnu proizvodnju u moru, koja čini bazu morske trofičke piramide. Fenomen žute morske površine dokumentiran je posljednjih godina duž jadranske obale od Kvarnera, Šibenika, Splita do Dubrovnika, a ne zna se koliko dugo pelud ostaje na površini, koliko se širi u dubinu i kakve posljedice ima u morskoj vodi. Interdisciplinarni projekt POLLMAR okupit će stručnjake iz atmosferskih kemije, aerobiologije, biogeokemije mora i oceanologije kako bi po prvi put proučavali unos peludi iz zraka u obalna područja srednjeg Jadrana tijekom glavne sezone oprašivanja od veljače do srpnja. Laboratorijskim eksperimentima istražit će se dinamika pucanja različitih peludnih zrnaca u uvjetima morske i bočate vode te će se identificirati i kvantificirati organski peludni materijal i karakterizirati onečišćivala koji se adsorbiraju na površini peludi. Provest će se mikrokozmos eksperiment inkubacije morske vode sa prikupljenim peludnim zrncima u usporedbi s otopljenim organskim peludnim tvarima koji će razjasniti utjecaj donosa peludi na primarnu proizvodnju. Ovo istraživanje je relevantno za Jadransko more, ali i druga oligotrofna obalna područja Sredozemlja koja mogu brzo reagirati na okolišni stres, a posebno na povremene i prekomjerne unose hranjivih tvari s kopna i iz atmosfere.]]></summary_hr><summary_en><![CDATA[Future climate change scenarios predict that pollen concentrations in the air will increase as pollination period lengthen due to increased atmospheric CO2 concentrations and higher temperatures. Land-sea interactions will become more intense, and because pollen contains a significant amount of organic nutrients, it is one of the allochthonous inputs to natural waters that may alter ecosystem dynamics. Although pollen input to freshwater systems (especially lakes) has been well studied, there is no information on effects of pollen input on phytoplankton production, a base of the marine trophic pyramid, in nearshore seawater. The phenomenon of yellow sea surface has been documented in recent years along the Adriatic coastal region from Kvarner, Šibenik, Split to Dubrovnik, and no one knows how long the pollen remains on the surface, how far it spreads at depth, and what consequences it leaves in the seawater. The interdisciplinary POLLMAR project will bring together experts in atmospheric chemistry, aerobiology, marine biogeochemistry, and oceanology to study, for the first time, the aerial pollen flux into the coastal areas of the central Adriatic Sea during the main pollination season (February to July). Laboratory experiments will investigate the dynamics of various pollen grain rupture under seawater and brackish water conditions, will identify and quantify the subpollen organic material leached, and will characterize the airborne pollutants that adsorb on the pollen grain surface. Finally, the microcosmos incubation experiment of collected pollen grains compared to dissolved organic subpollen matter will elucidate the effect of pollen input on marine primary production. This research is relevant to the Adriatic Sea as well as other oligotrophic coastal areas of the Mediterranean, which can respond rapidly to environmental stressors, especially occasional and excessive nutrient inputs from land and the atmosphere.]]></summary_en></project><project>
<id>18615</id><title_hr><![CDATA[Dizajniranje strategije za pozitivne učinke polifenolnih spojeva u specifičnim dijelovima probavnog trakta]]></title_hr><title_en><![CDATA[Designing Strategies for Beneficial Effects of Phenolic Compounds in Specific Parts of the Gastrointestinal Tract]]></title_en><user_id>7376</user_id><user_firstLast_name>Lidija Jakobek Barron</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-2244</code><acronim><![CDATA[BESgTphenolics]]></acronim><duration>05.12.2025 - 04.12.2028</duration><status>U tijeku</status><financ_value>192.472,00 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Prehrambena tehnologija, Nutricionizam, Interdisciplinarne biotehničke znanosti, </scie_field_hr><scie_field_en>Food technology, Nutrition, Interdisciplinary biotechnical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Prehrambeno-tehnološki fakultet]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Food Technology]]></institution_en><team_members_id>19843, 333, 19154, 870836, 870755, 870825, </team_members_id><team_members_names><![CDATA[Petra Matić, Ivica Strelec, Martina Skendrović Babojelić, Diana Roopchand, Tassos Kyriakides, Christopher Blesso, ]]></team_members_names><keywords_hr><![CDATA[voće, prehrambena vlakna, b-glukan, celuloza, želudac, tanko crijevo, bioaktivnost,]]></keywords_hr><keywords_en><![CDATA[fruits, dietary fibers, b-glucan, cellulose, stomach, small intestine, bioactivity,]]></keywords_en><summary_hr><![CDATA[Zbog potencijalno pozitivnog utjecaja na ljudsko zdravlje, polifenolni spojevi se intenzivno istražuju. Probavni sustav je prvi sustav ljudskog tijela koji može imati koristi od prisutnosti polifenola, a bioaktivnosti u probavnom sustavu povezane su s ublažavanjem brojnim zdravstvenih tegoba. No one nisu u potpunosti razjašnjene, posebno ako se u obzir uzme utjecaj matrixa hrane na polifenole. Da bi se razjasnile bioaktivnosti polifenola u specifičnim dijelovima probavnog sustava, važno je poznavati njihovo djelovanje u okruženju drugih sastojaka hrane kao što su prehrambena vlakna, koja čine značajan dio matrixa hrane. U ovom projektu cilj je istražiti pozitivno djelovanje polifenola voća (jabuke, aronija) u specifičnim dijelovima probavnog sustava (želudac, tanko crijevo), utjecaj prehrambenih vlakana (celuloza, b-glukan) ili hrane koje sadrže vlakna na pozitivne učinke, te dizajnirati strategije za najbolju bioaktivnost u želudcu ili tankom crijevu. Pozitivno djelovanje bit će usmjereno na mogućnost polifenola (samih, s prehrambenim vlaknima ili s hranom) nakon probave u želucu, za uklanjanje slobodnih sintetskih radikala ili reaktivnih karbonilnih vrsta (RCS, Reactive Carbonyl Species). Pozitivni učinci polifenola nakon probave u tankom crijevu (samih, s prehrambenim vlaknima ili s hranom), uključivat će hvatanje slobodnih radikala ili reaktivnih karbonilnih vrsta, inhibiciju enzima važnih za probavu ugljikohidrata (a-amilaza, a-glukozidaza), sposobnost vezanja na žučne kiseline ili inhibiciju aktivnosti lipaze. Takve aktivnosti pokazat će specifični potencijal polifenola u želudcu ili tankom crijevu, za ublažavanje hiperglikemije, hiperkolesterolemije, hiperlipidemije, te zarobljavanje RCS-a. Statistička analiza pokazat će kakav utjecaj imaju prehrambena vlakna ili hrana koja sadrži vlakna na bioaktivnosti te dati usmjerenje za razvoj strategije upotrebe polifenola s najboljim pozitivnim djelovanjem.]]></summary_hr><summary_en><![CDATA[Due to potential positive effects on human health, polyphenols are intensively studied. The digestive system is the first system of the human body that can benefit from the presence of polyphenols, and bioactivities in the digestive system are associated with the alleviation of numerous health problems. However, they are not fully understood, especially when considering the influence of the food matrix on polyphenols. In order to clarify the bioactivities of polyphenols in specific parts of the digestive system, it is important to know their action in the environment of other food ingredients such as dietary fibers, which constitute a significant part of the food matrix. In this project, the goals are to investigate the positive effects of fruit polyphenols (apples, chokeberry) in specific parts of the digestive system (stomach, small intestine), to determine the influence of dietary fibers (cellulose, b-glucan) or foods containing fiber on these positive effects, and to design strategies for the best bioactivity in the stomach or small intestine. The positive effects will be focused on the ability of polyphenols (alone, with dietary fiber or food) after digestion in the stomach to remove free radicals or reactive carbonyl species (RCS). The positive effects of polyphenols after digestion in the small intestine (alone, with dietary fiber or food) will include scavenging free radicals or RCS, inhibiting enzymes important for carbohydrate digestion (a-amylase, a-glucosidase), binding bile acids and inhibiting lipase activity. Such activities will demonstrate the specific potential of polyphenols in the stomach or small intestine to alleviate hyperglycemia, hypercholesterolemia, hyperlipidemia, and to trap RCS. Statistical analysis will show the impact of dietary fiber or fiber-containing foods on bioactivities and will provide guidance for the development of a strategy for using polyphenols with the best positive effects.]]></summary_en></project><project>
<id>18616</id><title_hr><![CDATA[Interactions in the Coccolithophore Phycosphere and Implications for Ocean Carbon Cycling]]></title_hr><title_en><![CDATA[]]></title_en><user_id>868240</user_id><user_firstLast_name>Frederic Chaux-Jukic</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-8042</code><acronim><![CDATA[Cocco-Channel]]></acronim><duration>13.01.2026 - 12.01.2031</duration><status>U tijeku</status><financ_value>60,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Interdisciplinarne prirodne znanosti, </scie_field_hr><scie_field_en>Interdisciplinary natural sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>873022</team_members_id><team_members_names><![CDATA[ Doktorand: Lucija Berlančić ]]></team_members_names><keywords_hr><![CDATA[morska mikrobiologija, ekologija fitoplanktona, co-culturing, okolišna biologija, kemijska oceanografija, ]]></keywords_hr><keywords_en><![CDATA[marine microbiology, phytoplankton ecology, co-culturing, environmental biology, chemical oceanography]]></keywords_en><summary_hr><![CDATA[Ocean je danas daleko najveći rezervoar ugljika i važan je ponor ugljika. Jedan od ključnih igrača u njegovoj sposobnosti snižavanja atmosferskog CO2 su kokolitoforidi. One su jednostanične morske alge koje pridonose globalnom ciklusu ugljika ne samo fotosintezom već i kalcifikacijom i njihove su stanice prekrivene kalcitnim pločama. Međutim, oni ne djeluju sami. Mikrookoliš koji ih okružuje bogat je hranjivim tvarima izvanstanične organske tvari i utočište bogate mikrobne zajednice. Ovo okruženje poznato je kao fikosfera, a interakcije mikroba unutar njega kreću se od pozitivnih do antagonističkih. Takvi odnosi značajno utječu na cjelokupnu dinamiku ekosustava, na primjer potičući ili prekidajući širenje velikih cvjetanja kokolitoforida. No, u tom mikrookruženju ima još puno nepoznanica. Projekt Cocco-Channel ima za cilj proučavanje interakcija između kokolitoforida i njihovih povezanih bakterijskih zajednica unutar fikosfere i razumijevanje kako ti odnosi utječu na sposobnost oceana da hvata CO2. Ovo istraživanje ima za cilj otkriti zamršenu dinamiku ovih interakcija na mikro razini integracijom metoda iz mikrobne biologije, genomike, oceanografije i kemije ugljika. Istražujući razmjenu i strukturu mikrobnih zajednica povezanih s različitim vrstama kokolitoforida, projekt ima za cilj pružiti dublji uvid u utjecaj tih mikroorganizama na oceanski ciklus ugljika. Uz laboratorijske pokuse i pokuse u mikrokozmosu, naše terenske studije analizirat će sastav, funkcije i dinamiku interakcije prirodnih zajednica kokolitoforida i njima pridružene mikrobiote. Ovaj sveobuhvatni pristup pomoći će kvantificirati utjecaj kokolitoforida na sekvestraciju ugljika i pružiti važne podatke za usavršavanje klimatskih modela i razvoj strategija za ublažavanje učinaka klimatskih promjena.]]></summary_hr><summary_en><![CDATA[The ocean is by far the largest carbon reservoir today and is an important carbon sink. One of the key players in its capacity to draw down atmospheric CO2 are coccolithophores. They are unicellular marine algae that contribute to this global carbon cycle not only through photosynthesis but also through calcification, as their cells are covered by calcite plates. However, they are not acting alone. The microenvironment that surrounds them is rich in nutrient dense extracellular organic matter and harbours a rich microbial community. This environment is known as the phycosphere, and the microbial interactions within it range from mutualistic to antagonistic. Such relationships significantly influence the overall dynamics of the ecosystem, for example by promoting or terminating the spread of large coccolithophore blooms. However, there are still many unknowns in this microenvironment. The Cocco Channel project aims to study the interactions between coccolithophores and their associated bacterial communities within the phycosphere and to understand how these relationships influence the ocean&#39;s ability to capture CO2. This research aims to uncover the intricate dynamics of these microscale interactions by integrating methods from microbial biology, genomics, oceanography and carbon chemistry. By exploring the exchange and the structure of microbial communities associated with different coccolithophore species, the project aims to provide deeper insights into the impact of these microorganisms on the oceanic carbon cycle. In addition to laboratory and microcosm experiments, our field studies will analyse the composition, functions and interaction dynamics of natural coccolithophore communities and their associated microbiota. This comprehensive approach will help to quantify the impact of coccolithophores on carbon sequestration and provide important data for the refinement of climate models and the development of strategies to mitigate the effects of climate change.]]></summary_en></project><project>
<id>18619</id><title_hr><![CDATA[Uspješno seksualno starenje – prospektivna dijadička studija mješovite metodologije]]></title_hr><title_en><![CDATA[]]></title_en><user_id>17799</user_id><user_firstLast_name>Goran Koletić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-8525</code><acronim><![CDATA[HEALTHSEXAGE]]></acronim><duration>01.12.2025 - 30.11.2031</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Sociologija, </scie_field_hr><scie_field_en>Sociology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>872971</team_members_id><team_members_names><![CDATA[ Doktorand: Danijela Vlahov ]]></team_members_names><keywords_hr><![CDATA[stariji parovi, uspješno seksualno starenje, seksualno zdravlje, dijadna mješovitometodološka studija, prospektivna procjene]]></keywords_hr><keywords_en><![CDATA[aging couples, successful sexual aging, sexual health, dyadic mixed method study, prospective assessment]]></keywords_en><summary_hr><![CDATA[Sve veći broj ljudi diljem zapadnog svijeta živi do duboke starosti te pridaje sve veću važnost seksualnom zdravlju. Međutim, postojeća znanstvena literatura o seksualnosti i starenju ograničena je: (a) nedostatkom konceptualne jasnoće o seksualnoj dobrobiti starijih osoba; (b) odsutnošću dijadnih analiza; (c) nepostojanjem prospektivnih istraživanja; i (d) nedostatkom primjene mješovite metodologije u istraživanju procesa seksualnog starenja. Naš interdisciplinarni istraživački projekt ima za cilj osloviti te nedostatke primjenom novog konceptualnog modela – uspješnog seksualnog starenja (SSA) – koji se temelji na modelima uspješnog starenja (Rowe i Kahn) i selektivne optimizacije s kompenzacijom. Kako bismo pružili razumijevanje temeljeno na dokazima o procesima koji leže u osnovi SSA i čimbenicima koji ga mogu spriječiti, koristimo robusnu metodologiju – longitudinalnu dijadnu procjenu i analitički pristup mješovite metodologije. Projekt će koristiti kvantitativne i kvalitativne podatke za: (1) istraživanje ključnih elemenata SSA; (2) opisivanje promjene u SSA i njegovih korelate; (3) procjenu uloge društvene povezanosti; (4) detektiranje moguće rodne specifičnosti SSA; i (5) utvrđivanje uloge osobne i seksualne povijesti para u dinamici SSA. Kvalitativni dio će uključivati 35-50 intervjua sa starijim parovima u drugoj projektnoj godini. Te će dijade biti podskup longitudinalnog panela (350-400 parova) koji će se ispitivati u tri navrata, u razmaku od 12 mjeseci (kvantitativni dio studije). Primijenit će se internetsko anketiranje koje je uspješno pilotirano 2020. godine. Predloženi istraživački projekt pružit će jedinstven doprinos literaturi o seksualnom starenju. Očekuje se da će njegovi konceptualni i empirijski uvidi unaprijediti razumijevanje starenja i seksualnosti, informirati stručnjake za društvenu gerontologiju i seksualno zdravlje te usmjeriti seksualno obrazovanje odraslih, intervencije u seksualnom zdravlju i savjetovanje starijih parova.]]></summary_hr><summary_en><![CDATA[An increasing number of people across the Western world are living into old age and placing a higher value on sexual health than previous generations. The existing literature on sexuality and aging, however, is limited by: (a) a lack of conceptual clarity about sexual well-being in older adults; (b) absence of dyadic assessments; (c) absence of prospective explorations; and (d) paucity of mixed method approaches to the process of sexual aging. Our interdisciplinary research project aims to fill these knowledge gaps by introducing a novel conceptual model – successful sexual aging (SSA) – that builds on the Successful Aging and Selective Optimization with Compensation models. To provide evidence-based understanding of the processes underlying SSA and factors that may impede it, we use robust methodology – longitudinal dyadic assessment and a mixed method analytical approach. The project will use quantitative and qualitative data to: (1) explore core elements of successful sexual aging (SSA); (2) describe changes in SSA and its correlates; (3) assess the role of social connectedness; (4) address possible gender-specificity of SSA; and (5) establish a role of personal and couple sexual history in the dynamics of SSA. The qualitative arm will entail 35-50 interviews with older couples in the second project year. These dyads will be a subset of a longitudinal panel (350-400 couples) that will be surveyed on three occasions, roughly 12 months apart (the quantitative study arm). Online surveying, which was successfully piloted in 2020, will be applied. The proposed research project will provide a unique contribution to the literature on sexual aging. Its conceptual and empirical insights are expected to advance the understanding of aging and sexuality, inform social gerontology and sexual health experts, and guide adults’ sexuality education, sexual health interventions, and counseling in older couples.]]></summary_en></project><project>
<id>18620</id><title_hr><![CDATA[Primjena metabolomike, fenotipizacije visoke propusnosti i molekularnih markera u ranoj selekciji na otpornost na bolesti kod razvoja novih sorata vinove loze]]></title_hr><title_en><![CDATA[]]></title_en><user_id>11198</user_id><user_firstLast_name>Darko  Preiner</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-3737</code><acronim><![CDATA[VitiResist]]></acronim><duration>19.11.2025 - 18.11.2031</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Agronomski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Agriculture]]></institution_en><team_members_id>872964</team_members_id><team_members_names><![CDATA[ Doktorand: Simona Hofer Geušić ]]></team_members_names><keywords_hr><![CDATA[Vinova loza, fenotipizacija, oplemenjivanje vinove loze, otpornost, markerima potpomognuta selekcija, otporne sorte]]></keywords_hr><keywords_en><![CDATA[Grapevine, phenotyping, selection, grapevine breeding, resistance, marker-assisted selection ]]></keywords_en><summary_hr><![CDATA[Moderno vinogradarstvo u Hrvatskoj i u svijetu bazira se uglavnom na sortama koje su osjetljive na različite bolesti i štetnike što za posljedicu ima primjenu neodrživo velikih količina pesticida u proizvodnji grožđa. Održivi razvoj vinogradarstva u budućnosti bit će moguć samo povećanjem otpornosti vinove loze kroz stvaranje novih sorata otpornih na bolesti, ali i abiotske stresove uzrokovane klimatskim promjenama. U vodećim vinogradarskim zemljama pokrenuti su oplemenjivački programi s ciljem razvoja novih sorata sa otpornošću na bolesti (otporne sorte), a koje istovremeno pokazuju visoku razinu kvalitete. Nove otporne sorte najčešće su nastale na bazi internacionalnih sorata (uglavnom francuskih i njemačkih) korištenjem klasičnog oplemenjivanja i selekcije potpomognute genetskim markerima (tzv. MAS - Marker Assisted selection).  Hrvatska je bogata autohtonim sortama vinove loze koje su osnova proizvodnje vina, a nisu prisutne u oplemenjivačkim programima drugih zemalja. Prijavitelj je 2015. godine  pokrenuo oplemenjivački program kojemu je dugoročni cilj razvoj otpornih sorata vinove loze stabilne i trajne otpornosti, korištenjem autohtone germplazme u kombinaciji sa različitim izvorima otpornosti koji su prisutni u dosad razvijenim otpornim sortama prikladnih za uzgoj u RH. Ovim projektom planira se unaprijediti sam postupak razvoja novih sorata kroz razvoj i primjenu metabolomičkih bio-markera vezanih uz otpornost na bolesti ili smanjenu osjetljivost na vodni stres i visoke temperature, fenotipizaciju visoke propusnosti, primjenu postojećih metoda selekcije baziranih na molekularnim markerima s ciljem piramidizacije otpornosti te razvoj metode rane procijene kvalitete grožđa u postupku selekcije. Navedenim istraživanjima planira se unaprijediti oplemenjivački postupak s obzirom na brzinu i učinkovitost kao i za razvoj sorata sa trajnom otpornošću na bolesti. ]]></summary_hr><summary_en><![CDATA[Modern viticulture in Croatia and the world is based mainly on varieties that are susceptible to various diseases and pests, which results in the unsustainably large amounts of pesticides used in grape production.  The sustainable development of viticulture in the future will only be possible by increasing the resistance of the grapevine through the development of new varieties resistant to diseases and abiotic stresses caused by climate change. Breeding programs have been launched in the leading wine-growing countries to develop new varieties with resistance to diseases (resistant varieties), which at the same time possess a high level of quality. New resistant varieties were most often created based on international varieties (mainly French and German) using classical breeding and selection supported by genetic markers (MAS - Marker Assisted selection). Croatia is rich in autochthonous grape varieties that are the basis of wine production, and are not present in the breeding programs of other countries. In 2015, the applicant started a breeding program whose long-term goal is the development of resistant varieties of grapevines with stable and durable resistance, using autochthonous germplasm in combination with different sources of resistance that are present in the resistant varieties developed so far suitable for growing in Croatia. This project has a goal to improve the process of grapevine breeding through the development of the application of metabolomic biomarkers associated with disease resistance or reduced sensitivity to water stress and high temperatures, high-throughput phenotyping, the application of existing selection methods based on molecular markers with the aim of pyramiding resistance, and the development of the method for early assessment of grape quality in the selection process. This way breeding process can be improved concerning duration and efficiency for the development of cultivars with durable resistance to diseases. ]]></summary_en></project><project>
<id>18621</id><title_hr><![CDATA[Ocean budućnosti: Hoće li promijenjeni sastav fitoplanktona pozitivno utjecati na biološku pumpu ugljika?]]></title_hr><title_en><![CDATA[]]></title_en><user_id>451</user_id><user_firstLast_name>Jelena Godrijan</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-2930</code><acronim><![CDATA[FUTURE OCEAN]]></acronim><duration>20.01.2026 - 19.01.2031</duration><status>U tijeku</status><financ_value>60,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Interdisciplinarne prirodne znanosti, </scie_field_hr><scie_field_en>Interdisciplinary natural sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>873071</team_members_id><team_members_names><![CDATA[ Doktorand: Leonarda Lazarin ]]></team_members_names><keywords_hr><![CDATA[Ocean budućnosti, biološka pumpa ugljika, organska tvar, lipidi, fotooksidacija, biodegradacija]]></keywords_hr><keywords_en><![CDATA[Future ocean, biological carbon pump, organic matter, lipids, photooxidation, biodegradation]]></keywords_en><summary_hr><![CDATA[Jedna od glavnih briga oceanologa je u kojoj će mjeri globalno zatopljenje i povezane promjene utjecati na sposobnost oceana da ublaže te utjecaje. „Biološka ugljikova pumpa“ (BCP), odnosno biološki vođeno izdvajanje ugljika (C) iz atmosfere i površine oceana na morsko dno jedan je od najvažnijih procesa koji pridonose ublažavanju klimatskih promjena. Proučavani su različiti parametri koji mogu utjecati na učinkovitost BCP-a. Razmjer do kojeg bi izmijenjeni sastav fitoplanktona bio podložan abiotičkoj (fotooksidacija) i biološkoj (fikosferske bakterije) razgradnji, nazvano bio/razgradnja, još nije proučavan niti razmatran u scenarijima klimatskih promjena. Predviđanja su da će klimatske promjene dovesti do manje proizvodnje dijatomeja, što će se kompenzirati kokolitoforidima. Obje skupine imaju potencijal potonuća zbog teških ljuski na površini stanice. Planiramo uzgajati dijatomeju i kokolitoforidu u optimalnim i nepovoljnim uvjetima koji oponašaju zagrijavanje i oligotrofiju. Kulture iz stacionarne faze rasta bile bi podvrgnute bio/razgradnji. Složenim metodološkim pristupom analizirat ćemo količinu i kvalitetu organske tvari (OT), posebice lipida, uključujući DOC, POC, SAS, CDOM, FDOM, zajedno s morfologijom stanice, pigmentima, sadržajem C, N i P te ekspresijom gena povezanih s lipidima. Kako bi se dopunili rezultati laboratorijskih pokusa, uzimat će se uzorci morske vode tijekom razdoblja cvatnje dijatomeja i kokolitoforida. Lipidi su zanimljivi jer se pokazalo da se selektivno čuvaju u dubokom moru. Naš će projekt dati uvid u to hoće li OT fitoplanktona, posebice lipidi, biti više ili manje razgradivi u budućem oceanu. Naše predviđanje je da će OT, posebno lipidi, kokolitofora biti stabilniji od onih dijatomeja. Naši rezultati pružit će dodatna znanja za predviđanje u kojoj će mjeri globalne promjene utjecati na BCP.]]></summary_hr><summary_en><![CDATA[One of the major concerns of marine scientists is the extent to which global warming and the associated changes will affect the ability of oceans to mitigate these impacts. The &#39;&#39;biological carbon pump&#39;&#39; (BCP), i.e., biologically driven C sequestration from the atmosphere and surface ocean to the seafloor is one of the most important processes contributing to the mitigation of climate change. A variety of parameters that may affect the effectiveness of the BCP have been studied. The extent to which altered phytoplankton composition would be subject to abiotic (photooxidation) and biological (phycosphere bacteria) degradation, termed bio/degradation, has not yet been studied or considered in climate change scenarios. The predictions are that climate change will lead to lower production of diatoms, which will be compensated for by coccolithophores. Both groups have the potential to sink due to the heavy shells on the cell surface. We plan to grow diatom and coccolithophore under optimal and unfavourable conditions mimicking warming and oligotrophy. Cultures from the stationary growth phase would be subjected to bio/degradation. Using a complex methodological approach, we will analyse the quantity and quality of organic matter (OM), especially lipids, including DOC, POC, SAS, CDOM, FDOM, together with cell morphology, pigments, C, N and P content and gene expression related to lipids. To supplement the results of the laboratory experiments, seawater samples will be taken during the diatom and coccolithophore bloom periods. Lipids are of interest because they are selectively preserved in the deep sea. Our project will provide insight into whether phytoplankton OM, particularly lipids, will be more or less degradable in the future ocean. Our prediction is that the OM, especially lipids, of coccolithophores will be more stable than those of diatoms. Our results will provide additional knowledge for predicting the extent to which global change will affect BCP.]]></summary_en></project><project>
<id>18623</id><title_hr><![CDATA[Između znanja i neznanja: ideje, prakse i nasljeđe prosvjetiteljstva u hrvatskim zemljama]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1124</user_id><user_firstLast_name>Teodora Shek Brnardić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-8287</code><acronim><![CDATA[LIGHT]]></acronim><duration>03.11.2025 - 03.11.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Povijest, </scie_field_hr><scie_field_en>History, </scie_field_en><institution_hr><![CDATA[Hrvatski institut za povijest]]></institution_hr><institution_en><![CDATA[Croatian Institute of History]]></institution_en><team_members_id>872887</team_members_id><team_members_names><![CDATA[ Doktorand: MATEA MARUSIC ]]></team_members_names><keywords_hr><![CDATA[prosvjetiteljstvo, povijest knjige, katoličko prosvjetiteljstvo, hrvatska povijest, cirkulacija znanja, Francuska revolucija]]></keywords_hr><keywords_en><![CDATA[Enlightenment, history of books, Catholic Enlightenment, Croatian history, circulation of knowledge, French Revolution]]></keywords_en><summary_hr><![CDATA[Cilj projekta je mapirati i identificirati obilježja i geografiju prosvjetiteljstva kao intelektualnog pokreta i kulturnog procesa koji je značajno oblikovao moderno doba u kontekstu hrvatskih zemalja u &#39;&#39;dugom&#39;&#39; 18. stoljeću. Iako su prosvjetiteljstvo i njegovo nasljeđe kao predmet istraživanja uvelike prisutni u svjetskoj historiografiji, hrvatska perspektiva na ovu temu uglavnom je neistražena. Stoga projekt LIGHT nastoji ispraviti ovaj znanstveni propust fokusirajući se po prvi put na prosvjetiteljski diskurs unutar hrvatskih konteksta (civilna Hrvatska, Slavonija, Dalmacija i Dubrovačka Republika). Tijekom trogodišnjeg razdoblja, istraživački će tim, prvo, interdisciplinarno analizirati prethodne interpretacije i konceptualizacije prosvjetiteljstva u hrvatskim zemljama i Europi preko odabranih studija slučaja. Drugo, istraživanje će učiniti vidljivima neke ključne aktere hrvatskog prosvjetiteljstva i njihove transnacionalne intelektualne mreže. Treće, bit će odabrani karakteristični izvorni tekstovi hrvatskih prosvjetitelja koji će služiti kao polazište za buduća istraživanja. Tematska područja obuhvaćat će &#39;&#39;katoličko prosvjetiteljstvo&#39;&#39;, &#39;&#39;cirkulaciju prosvjetiteljskog znanja&#39;&#39; i &#39;&#39;prosvjetiteljstvo i revoluciju&#39;&#39;. Rezultati projekta uključivat će niz izvješća, anotiranih bibliografija, znanstvenih radova, prvu doktorsku disertaciju na temu prosvjetiteljstva u hrvatskim zemljama, te kreiranje prve digitalne čitanke tekstova hrvatskog prosvjetiteljstva. Nadalje, tim namjerava organizirati tri radionice i doktorski okrugli stol kako bi potaknuo akademsku raspravu i daljnju suradnju u ovom području.]]></summary_hr><summary_en><![CDATA[The aim of the project is to map and identify the features and geography of the Enlightenment as both an intellectual movement and cultural process that significantly shaped the modern era within the context of Croatian lands in the &#39;&#39;long&#39;&#39; 18th century. While the Enlightenment and its legacy have been extensively studied in world historiography, the Croatian perspective on this subject remains largely unexplored. Consequently, the LIGHT project endeavours to rectify this scholarly oversight by focusing on the Enlightenment discourse within Croatian contexts (Civil Croatia, Slavonia, Dalmatia, and Republic of Ragusa) for the first time. Over a three-year period, the research team will, firstly, undertake an interdisciplinary analysis of prior interpretations and conceptualizations of the Enlightenment across Croatian lands and Europe, drawing from selected case studies. Secondly, the investigation will highlight some key actors of the Croatian Enlightenment and explore their transnational intellectual networks. Thirdly, the team will compile a collection of original texts authored by the Croatian Enlightenment actors, which will serve as foundational resources for future scholarship. The thematic focus areas encompass &#39;&#39;the Catholic Enlightenment,&#39;&#39; &#39;&#39;the circulation of Enlightenment knowledge,&#39;&#39; and &#39;&#39;the Enlightenment and revolution.&#39;&#39; The project&#39;s outcomes will include a series of scholarly reports, annotated bibliographies, scientific papers, a pioneering doctoral dissertation on the Croatian Enlightenment, and the creation of a digital reader featuring primary texts by key actors. Furthermore, the team intends to convene three workshops and a doctoral roundtable to foster academic discourse and further collaboration in this field. ]]></summary_en></project><project>
<id>18624</id><title_hr><![CDATA[ERC Synergy grant GlycanSwitch (grant #101071386)]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5420</user_id><user_firstLast_name>Gordan Lauc</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-8252</code><acronim><![CDATA[]]></acronim><duration>05.12.2025 - 04.12.2031</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Farmaceutsko-biokemijski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Pharmacy and Biochemistry]]></institution_en><team_members_id>873021</team_members_id><team_members_names><![CDATA[ Doktorand: Lana Semenić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>18625</id><title_hr><![CDATA[Narodni život i svakodnevni običaji sjevernog Jadrana]]></title_hr><title_en><![CDATA[Folk life and daily customs of the northern Adriatic]]></title_en><user_id>28176</user_id><user_firstLast_name>Kosana Jovanović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2025-02</proposal_call><code>UIP-2025-02-8173</code><acronim><![CDATA[ARTISAN]]></acronim><duration>19.02.2026 - 18.02.2031</duration><status>U tijeku</status><financ_value>280.040,00 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Povijest, Povijest umjetnosti, Arheologija, Etnologija i antropologija, Interdisciplinarne humanističke znanosti, </scie_field_hr><scie_field_en>History, Art history, Archeology, Ethnology and anthropology, Interdisciplinary humanities, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Filozofski fakultet u Rijeci]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>870880, 6905, 870883, 870891, </team_members_id><team_members_names><![CDATA[Katarina Čović, Palma Karković, Ema Čolaković, Petra Radolović, ]]></team_members_names><keywords_hr><![CDATA[narodni život, svakodnevica, običaji, sjeverni Jadran, povijest]]></keywords_hr><keywords_en><![CDATA[folk life, every day life, customs, northern Adriatic, history]]></keywords_en><summary_hr><![CDATA[Ovaj projektni prijedlog odnosi se na problematiku implementacije znanstveno-istraživačkog rada s ciljem očuvanja i valorizacije etnografske materijalne i nematerijalne baština svakodnevnih narodnih običaja sjevernog Jadrana, kao i njezine rekonstrukcije u svrhu održivosti i upotrebe za turističke i gospodarske potrebe. Projekt ARTISAN - Narodni život i svakodnevni običaji sjevernog Jadrana nastaje iz znanstvenog interesa za sistematičnim istraživanjem podataka o svakodnevici i narodnim običajima, kao i potrebe za očuvanjem ove vrste kulturne baštine. Sa znanstveno-istraživačkog aspekta projekt adresira problem nedovoljno istraženih pojavnosti vezanih uz kulturnu baštinu Kvarnera i kvarnerskog primorja s ciljem rješavanja tog problema putem prikupljanja, pohrane i obrade podataka o materijalnoj i nematerijalnoj baštini svakodnevnih narodnih običaja sjevernog Jadrana te korištenja iste za znanstveno-istraživački rad ali i stavljanjem u upotrebu za turističke i gospodarske potrebe lokalne zajednice, ostvarujući tako jedan od svojih temeljnih ciljeva provedbe, transfer znanja. Rezultatima znanstveno-istraživačkog rada koristit će se znanstvena i šira zajednica. ]]></summary_hr><summary_en><![CDATA[This project proposal refers to the issue of implementation of scientific and research work with the aim of preserving and valorizing ethnographic tangible and intangible heritage of everyday folk customs of the northern Adriatic, as well as its reconstruction for the purpose of sustainability and use for touristic and economic needs. The project ARTISAN - Folk life and daily customs of the northern Adriatic arises out of scientific interest in the systematic research of data on everyday life and folk customs, as well as the need to preserve this type of cultural heritage. From the scientific-research aspect, the project addresses the problem of insufficiently researched phenomena related to the cultural heritage of Kvarner and the Kvarner littoral with the aim of solving this problem by collecting, storing and processing data on the tangible and intangible heritage of everyday folk customs of the northern Adriatic and using it for scientific-research work but also by putting it to use for the touristic and economic needs of the local community, thus achieving one of its fundamental implementation goals, knowledge transfer. The results of the scientific and research work will be used by the scientific and wider community.]]></summary_en></project><project>
<id>18627</id><title_hr><![CDATA[Parcijalna dealkoholizacija vina primjenom membranskih procesa napredne i reverzne osmoze kao odgovor na klimatske izazove]]></title_hr><title_en><![CDATA[]]></title_en><user_id>13272</user_id><user_firstLast_name>Natka Ćurko</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-5017</code><acronim><![CDATA[FoRoClimaWINE]]></acronim><duration>09.02.2026 - 08.02.2032</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Prehrambena tehnologija, </scie_field_hr><scie_field_en>Food technology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Food Technology and Biotechnology]]></institution_en><team_members_id>873104</team_members_id><team_members_names><![CDATA[ Doktorand: Irena Zanini ]]></team_members_names><keywords_hr><![CDATA[reverzna osmoza, napredna osmoza, dealkoholizacija, kvaliteta vina, klimatske promjene]]></keywords_hr><keywords_en><![CDATA[reverse osmosis, forward osmosis, dealcoholization, wine quality, climate changes]]></keywords_en><summary_hr><![CDATA[Prilagođavanje posljedicama klimatskih promjena, kroz unaprjeđenje postojećih tehnologija i razvoj novih, jedan je od ključnih enoloških izazova. Negativan utjecaj klimatskih djelovanja razvidan je i kroz povećanje udjela alkohola u vinu od čak 3-4 % vol. tijekom posljednja tri desetljeća, što danas rezultira vinima s 15 i više % vol. alkohola. Visoki udjeli alkohola imaju izrazito negativan utjecaj na senzorske karakteristike vina, a uzrokuju povećanje osjeta „žarenja“ i „paljenja“, povećanje gorčine, ali i smanjenje kompleksnosti arome, voćnosti te ukupne harmoničnosti. Enološke metode dealkoholizacije najčešće uključuju primjenu membranskih procesa poput reverzne osmoze, ali zahtijevaju daljnju optimizaciju s ciljem umanjenja utjecaja na kemijske i senzorske karakteristike vina. S druge strane, mogućnosti napredne osmoze kao novog membranskog procesa dealkoholizacije vina su u potpunosti neistražene. Alternativne enološke strategije uključuju fermentaciju s low alcohol Saccharomyces ili non-Saccharomyces kvascima te smanjenje alkohola za -2 % vol., dok je njihov utjecaj na kemijske i senzorske karakteristike vina manje poznat. Cilj ovog projekta je istražiti različite metode smanjenja udjela alkohola u vinu uključujući membranske procese reverzne osmoze i napredne osmoze, biološki proces fermentacije s low alcohol Saccharomyces cerevisiae kvascem te kombinaciju bioloških i membranskih procesa, temeljem njihovog utjecaja na kemijski sastav (aroma i polifenolni spojevi) i senzorske karakteristike vina. Također, odredit će se i dugoročan efekt navedenih procesa tijekom dozrijevanja i starenja u bocama na kvalitetu vina. Rezultati ovog projekta omogućit će usporedbu novog membranskog postupka napredne osmoze s reverznom osmozom, pojedinačno te u kombinaciji s biološkim postupkom. Temeljem navedenog odabrat će optimalan proces i parametri parcijalne dealkoholizacije vina uz očuvanje njegove arome, polifenolnog sastava i senzorske kompleksnosti.]]></summary_hr><summary_en><![CDATA[Mitigating and adapting to climate changes, by improving existing and developing new technologies is one of the most important enological challenges. The negative effects of climate are reflected in an increase in the alcohol content of wine by 3-4% vol. over the last three decades, today resulting in wines exceeding 15% vol. High alcohol content negatively affects sensory attributes of wine by increasing the perception of &#39;&#39;hotness&#39;&#39; and &#39;&#39;burning&#39;&#39;, increasing bitterness and reducing aroma complexity, fruitiness and overall harmony. Enological dealcoholization methods usually involve the use of membrane processes such as reverse osmosis, but require further optimization to minimize their impact on wine chemical and sensory characteristics. On the other hand, the potential of forward osmosis as a new membrane process for wine dealcoholization is still largely unexplored. Alternative enological strategies such as fermentation with low alcohol Saccharomyces or non-Saccharomyces yeasts can reduce alcohol content by -2% vol., but their effect on the chemical and sensory characteristics of wine is less known. The aim of this project is to study the effects of different partial dealcoholization methods, including the membrane processes of reverse osmosis and forward osmosis, the biological process of fermentation with low alcohol Saccharomyces cerevisiae yeast and the combination of biological and membrane processes, on the chemical composition (aroma and polyphenolic compounds) and sensory characteristics of wine. In addition, the long-term effects of these processes on wine quality during maturation and aging in bottles will be determined. The results will enable the comparison among forward osmosis, a novel membrane process, and reverse osmosis, both separately and combined with the biological process. Finally, the optimal process and its parameters for the partial dealcoholization of wine sustaining aroma, polyphenolic composition and sensory complexity will be defined.]]></summary_en></project><project>
<id>18636</id><title_hr><![CDATA[Rani bihevioralni markeri neurorazvojnih odstupanja vidno-prostorne obrade i vidno-motoričke integracije u nedonoščadi]]></title_hr><title_en><![CDATA[]]></title_en><user_id>12564</user_id><user_firstLast_name>Ana Katušić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-4850</code><acronim><![CDATA[PRE-VISOR]]></acronim><duration>01.11.2025 - 31.10.2031</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Edukacijsko-rehabilitacijske znanosti, </scie_field_hr><scie_field_en>Physical education and rehabilitation sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Edukacijsko-rehabilitacijski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Education and Rehabilitation Sciences]]></institution_en><team_members_id>872890</team_members_id><team_members_names><![CDATA[ Doktorand: Bruna Bašić ]]></team_members_names><keywords_hr><![CDATA[vidno-prostorna obrada, vidno-motorička integracija, nedonoščad, spontani pokreti, vidne funkcije, bihevioralni markeri]]></keywords_hr><keywords_en><![CDATA[visuospatial processing, visual-motor integration, preterm infants, general movements, visual function, behavioural markers]]></keywords_en><summary_hr><![CDATA[Nedonošenost se uglavnom povezuje s teškim neurorazvojnim poremećajima. Međutim, blagi neurorazvojni poremećaji koji uglavnom uključuju kognitivne deficite u vidno-prostornoj obradi i vidno-motoričkoj integraciji često se primjećuju u nedonoščadi. Učestalost vidno-prostornih i vidno-motoričkih teškoća u ovoj populaciji je visoka i &#39;&#39;izvan radara&#39;&#39; neurorazvojnog praćenja. Ovi deficiti predstavljaju trajnu kognitivnu disfunkciju koja utječe na adaptivno ponašanje i obrazovni uspjeh, a zapanjujuće su uočeni i kod nedonoščadi bez ili s blagim perinatalnim oštećenjem mozga kod kojih je predikcija razvojnog ishoda najzahtjevnija. Stoga postoji jasna potreba za istraživanjem bihevioralnih markera u podlozi ovih specifičnih kognitivnih deficita. Vidno-prostorne i vidno-motoričke funkcije razvijaju se rano i regulirane su opsežnom neurološkom mrežom koja se u ranoj dobi odražava motoričkim i vidnim ponašanjem. Promjene u ranim motoričkim i vidnim funkcijama refleksije su neurološke reorganizacije i temelj kaskade kognicije. Ovaj projekt će analizirati funkcije prominentnih ranih ponašanja, spontane pokretljivosti i gledanja, za koje smatramo da su u osnovi razvoja vidno-prostornih i vidno-motoričkih funkcija. Glavni je cilj projekta definirati rane bihevioralne markere za razvojna odstupanja u vidno-prostornoj obradi i vidno-motoričkoj integraciji kod nedonoščadi. Uzorak će činiti vrlo nedonošena dojenčad bez ili s blagim oštećenjem mozga. Kvaliteta spontane pokretljivosti i funkcija fiksacije i praćenja vidnih meta procijenit će se u novorođenačkoj i dojenačkoj dobi. Vidno-prostorne i vidno-motoričke funkcije ispitat će se bihevioralnim testovima i metodom praćenja pokreta oka u 3. godini. Pristup strojnog učenja koristit će se za prepoznavanje ranih značajki ponašanja relevantnih za predviđanje ishoda. Naši će rezultati razjasniti odnos između ranog motoričkog i vidnog ponašanja i razvoja specifičnih kognitivnih domena te ukazati na potencijalne bihevioralne prediktore.]]></summary_hr><summary_en><![CDATA[Prematurity is usually matched with severe neurodevelopmental disorders. Still, also mild neurodevelopmental disorders, mainly involving cognitive deficits in visuospatial processing and visual-motor integration are commonly noted in preterm infants. The frequency of visuospatial and visual-motor deficits in this population is high and “off the radar” of neurodevelopmental monitoring. Such deficits can imply permanent cognitive dysfunction affecting adaptive behavior and academic outcomes and are strikingly observed also in preterm infants with no or mild perinatal brain injury in which prediction of developmental outcome is challenging. Hence, there is a clear need to explore behavioral markers underlying these specific cognitive deficits. Visuospatial and visual-motor functions develop early and are regulated by an extensive neurological network that is reflected in motor and visual behavior at an early age. Changes in early motor and visual functions reflect this neurological reorganization and are the basis of cognition. This project will analyze functions of prominent early behaviors, spontaneous motility and looking, which we believe underly visuospatial and visual-motor development. The main goal is to define early behavioral markers for developmental alterations in visuospatial processing and visual-motor integration in preterm infants. The sample will consist of very preterm infants with no or mild brain injury. The quality of spontaneous motility and the function of fixation and tracking of visual targets will be assessed in newborn and infant age. Visuospatial and visual-motor functions will be evaluated with behavioral tests and the eye-tracking method in the 3rd year. A Machine Learning approach will be used to identify early behavioral features relevant to outcome prediction. Our results will clarify the link between early motor and visual behavior and the development of specific cognitive domains and indicate potential behavioral predictors.]]></summary_en></project><project>
<id>18641</id><title_hr><![CDATA[Fitokemijska karakterizacija i biološka aktivnost ekstrakata vrste Globularia alypum L. s potencijalnom kozmeceutskom vrijednošću]]></title_hr><title_en><![CDATA[Phytochemical characterization and biological activity of extracts from Globularia alypum L. with potential cosmeceutical worth]]></title_en><user_id>29172</user_id><user_firstLast_name>Maja Friščić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2025-02</proposal_call><code>UIP-2025-02-7092</code><acronim><![CDATA[Phytoactive GLOW]]></acronim><duration>01.04.2026 - 31.03.2031</duration><status>U tijeku</status><financ_value>300.000,00 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo, Prirodne znanosti, Biotehničke znanosti, </scie_area_hr><scie_area_en>Biomedicine and health sciences, Natural sciences, Biotechnical sciences, </scie_area_en><scie_field_hr>Farmacija, Kemija, Biologija, Biotehnologija, </scie_field_hr><scie_field_en>Pharmaceutical sciences, Chemistry, Biology, Biotechnology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Farmaceutsko-biokemijski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Pharmacy and Biochemistry]]></institution_en><team_members_id>870455, 858334, 29396, </team_members_id><team_members_names><![CDATA[Zora Rukavina, Mirna Perkušić, Tihana Marić, ]]></team_members_names><keywords_hr><![CDATA[Globularia alypum, kozmeceutici, zelena otapala, NADES, fitokemijski profil, anti-age učinak, formulacije s biljnim ekstraktima, liposomi, hidrogelovi]]></keywords_hr><keywords_en><![CDATA[Globularia alypum, cosmeceuticals, green solvents, NADES, phytochemical profile, anti-age effect, plant extract formulations, liposomes, hydrogels]]></keywords_en><summary_hr><![CDATA[Primjena kvalitetnih i učinkovitih kozmetičkih proizvoda u njezi kože može pozitivno utjecati na opće blagostanje i kvalitetu života pojedinaca, a time posredno i na njihovo zdravlje, koje je prema definiciji Svjetske zdravstvene organizacije stanje potpunog tjelesnog, mentalnog i socijalnog blagostanja, a ne samo odsustvo bolesti ili slabosti. Proizvodi za njegu kože čine najveći udio na svjetskom kozmetičkom tržištu, pri čemu njegov najbrže rastući segment čine kozmeceutici. Kozmeceutici su topički proizvodi za kožu koji održavaju njezin integritet i smanjuju prijevremeno starenje odnosno koji sadrže funkcionalne sastavnice koje uz kozmetičke pokazuju i farmaceutske (medicinske) učinke. Potražnja za ovim proizvodima s naglaskom na one koji sadrže sastavnice prirodnog podrijetla poput biljnih ekstrakata bogatih antioksidansima, za koje se smatra da mogu suzbiti znakove prijevremenog starenja kože (tzv. anti-age proizvodima) u kontinuiranom je porastu. Unatoč tome, podaci o fitokemijskom sastavu i sadržaju aktivnih sastavnica, kao i biološkim učincima, sigurnosti i stabilnosti gotovih kozmetičkih proizvoda koji sadrže biljne sastavnice ili ekstrakte često su slabo poznati ili u manjoj mjeri dostupni široj javnosti te mogu značajno varirati s obzirom na svojstva početnog biljnog materijala, uvjete njegove ekstrakcije te stabilnost konačne formulacije. Cilj ovog projekta je utvrditi potencijalnu kozmeceutsku vrijednost ekstrakata vrste Globularia alypum L. kao bogatog izvora prirodnih antioksidansa, pripremljenih zelenim tehnikama ekstrakcije, s obzirom na sadržaj i sastav biološki aktivnih spojeva te odabrane biološke učinke u uvjetima in vitro, kao i razviti te karakterizirati optimalnu formulaciju pogodnu za njihovo uklapanje i primjenu na kožu.]]></summary_hr><summary_en><![CDATA[The use of quality and effective cosmetic products in skin care can have a positive effect on the general well-being and quality of life of individuals, and thus indirectly on their health, which according to the definition of the World Health Organization is a state of complete physical, mental and social well-being, and not merely the absence of disease or infirmity. Skin care products account for the largest share of the global cosmetics market, with cosmeceuticals being its fastest growing segment. Cosmeceuticals are topical products for skin that maintain its integrity and reduce premature aging, that is, they contain functional components that, in addition to cosmetic effects, also have pharmaceutical (medical) effects. The demand for these products, with an emphasis on those containing components of natural origin, such as plant extracts rich in antioxidants, which are believed to be able to suppress the signs of premature skin aging (anti-aging products), is continuously increasing. Despite this fact, data on the phytochemical composition and content of active ingredients, as well as biological effects, safety and stability of final cosmetic products that contain herbal ingredients or extracts are often poorly known or less available to the public and can vary significantly considering the properties of the initial plant material, conditions of its extraction and the stability of the final formulation. The goal of this project is to determine the potential cosmeceutical worth of extracts from Globularia alypum L. as a rich source of natural antioxidants, prepared by green extraction techniques, with regard to the content and composition of biologically active compounds and selected biological effects under in vitro conditions, as well as to develop and characterize an optimal formulation suitable for their incorporation and skin application.]]></summary_en></project><project>
<id>18642</id><title_hr><![CDATA[Određivanje karakteristika učenika korištenjem edukacijskih robotskih tehnologija]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6592</user_id><user_firstLast_name>Ana Sović Kržić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-8664</code><acronim><![CDATA[DESCARTES]]></acronim><duration>08.12.2025 - 07.12.2031</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>872927</team_members_id><team_members_names><![CDATA[ Doktorand: Leon Stjepan Uroić ]]></team_members_names><keywords_hr><![CDATA[Edukacijski roboti, Kognitivne sposobnosti, model učenika, strojno učenje, značajke, fiziološki signali, karakteristike učenika]]></keywords_hr><keywords_en><![CDATA[Educational robots, cognitive abilities, student model, machine learning, features, physiological signals, students’ characteristics]]></keywords_en><summary_hr><![CDATA[Cilj DESCARTES projekta je pronaći odgovor na pitanje mogu li edukacijski roboti pomoći pri određivanju kognitivnih sposobnosti učenika (npr. pažnje, percepcije, pamćenja, prostorne orijentacije i slično). Edukacijski roboti su svojom formom i funkcionalnošću prilagođeni učenicima – pružaju im poznatu okolinu kao logični nasljednici igračaka, povezuju apstraktno s fizičkim, potiču kreativnost i omogućuju istovremeni rad svih učenika u razredu te su stoga idealno sredstvo za predikciju mjerljivih kognitivnih karakteristika učenika. U okviru projekta će biti dizajnirane radionice s edukacijskim robotskim tehnologijama pomoću kojih će se kod učenika stimulirati kognitivne funkcije od istraživačkog interesa (npr. održavanje i usmjeravanje pažnje, vidno-motoričke sposobnosti, prostorna orijentacija i slično). Podaci s robota i fiziološki signali učenika prikupljeni za vrijeme radionice će se analizirati korištenjem metoda strojnog učenja te će ih se validirati rezultatima standardiziranih testova kognitivnih sposobnosti učenika. Rezultati projekta će biti korisni za odgojno-obrazovne intervencije i nastavnike kako bi bolje razumjeli učenike s kojima rade te kako bi svako pojedino dijete dobilo odgovarajuću potporu ovisno o osobnim potencijalima ili teškoćama.]]></summary_hr><summary_en><![CDATA[The aim of the DESCARTES project is to find an answer to the question of whether educational robots can help determine students&#39; cognitive abilities (e.g., attention, perception, memory, spatial orientation, etc.). Educational robots are suited for students considering their form and functionality - they provide a familiar environment as the logical successors of toys, cohere the abstract with the physical, encourage creativity and enable the simultaneous work of all students in the class, and are therefore an ideal tool for predicting measurable cognitive characteristics of students. Within the project, workshops will be designed using educational robotic technologies, which will aid in stimulating students&#39; cognitive functions of research interest (e.g., maintaining and directing attention, visual-motor skills, spatial orientation, etc.). Data from the robot and students’ physiological signals collected during the workshop will be analyzed using machine learning methods and validated using the standardized tests of students&#39; cognitive abilities. The results of the project will benefit educational interventions and teachers by advancing the understanding of their students and providing an opportunity that each individual child receives appropriate support depending on personal potentials or difficulties.]]></summary_en></project><project>
<id>18653</id><title_hr><![CDATA[Reprezentacija, razvoj, edukacija, participacija – umjetnost u društvu od 19. do 21. stoljeća]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3499</user_id><user_firstLast_name>Dragan Damjanović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-9569</code><acronim><![CDATA[ARTINS]]></acronim><duration>01.01.2026 - 31.12.2031</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Povijest umjetnosti, </scie_field_hr><scie_field_en>Art history, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>872983</team_members_id><team_members_names><![CDATA[ Doktorand: Ana-Marija Senfner ]]></team_members_names><keywords_hr><![CDATA[Povijest umjetnosti, Umjetnost XIX. stoljeća, Umjetnosti XX. stoljeća, Umjetnost i društvo, muzeji, baština, identiteti]]></keywords_hr><keywords_en><![CDATA[Art History, 19th Century Art, 20th Century Art, Art and Society, Museums, Heritage, Identities]]></keywords_en><summary_hr><![CDATA[Projekt “Reprezentacija, razvoj, edukacija, participacija – umjetnost u društvu od 19. do 21. stoljeća” istraživat će različite aspekte umjetničke produkcije i prezentacije umjetnosti od početka 19. stoljeća do danas na području Hrvatske. To je razdoblje obilježeno velikim promjenama u ustrojstvu društva koje su redovito imale (i imaju i danas) utjecaj na umjetnost, ne samo u smislu da se odražavaju na formalnim karakteristikama djela vizualnih umjetnosti, nego se i njihova forma i sadržaj koriste za postizanje društvenih ciljeva, kako na razini specifičnih zajednica tako i društva u cjelini. Ovim se projektom nastoji na prvom mjestu upotpuniti istraživanja koja odražavaju usmjerenje u umjetničkoj teoriji i praksi prema društvenoj povijesti i društvenoj sadašnjosti, a koja su u hrvatskom istraživačkom prostoru povijesti umjetnosti i vizualnih komunikacija tek djelomično istražena. Promjene koje su se dogodile u odnosu umjetnosti i društva u navedenome razdoblju proučavat će se kroz četiri podteme: 1) kroz način na koji je oblikovan prostor i identitet zajednica, 2) kroz istraživanja uloga umjetnosti u razvoju društvenog standarda, 3) kroz istraživanje pristupa edukaciji o umjetnosti i putem umjetnosti na razini društva i specifičnih zajednica, i naposljetku 4) kroz istraživanje suradničkih odnosa u produkciji i komunikaciji umjetnosti. Istraživački tim čini 14 znanstvenika koji rade na svim sveučilištima u Hrvatskoj na kojima se predaje povijest umjetnosti te u dvama muzejima. Riječ je o istraživačima specijaliziranim za raznolike teme vezane uz povijest umjetnosti Hrvatske 19., 20. i 21. stoljeća: slikarstvo, kiparstvo, arhitekturu, vizualne komunikacije, povijest povijesti umjetnosti, muzeologiju i slično. Trećinu tima (5 istraživača) čine mlađi znanstvenici za čiji formativni razvoj projekt može imati odlučujuću ulogu. Tijekom realizacije projekta planira se zapošljavanje jednog doktoranda. ]]></summary_hr><summary_en><![CDATA[The project &#39;&#39;Representation, Development, Education, Participation - Art in Society in 19th – 21st centuries&#39;&#39; will explore different aspects of artistic production and presentation of art from the beginning of the 19th century to the present day in Croatia. This period was marked by major structural changes in society that regularly had (and still have) an impact on art, not only in the sense that they are reflected in the formal characteristics of art works and architecture, but also that their form and content have been used to achieve social goals, both at the level of specific communities and society as a whole. The aim of the project is to expand on the research that are based on artistic theory and practice of social history and the social present, which in the Croatian research area of the history of art and visual communications has only been partially investigated. The changes that took place in the relationship between art and society in the mentioned period will be studied through four objectives: 1) through the way in which the space and identity of communities were shaped, 2) through research into the role of art in the development of social standards, 3) through research into approaches to education about art and through art at the level of society and specific communities and finally 4) through research of collaborative relationships in the production and communication of art. The project team comprises 14 researchers working at all Croatian universities where art history is taught and at two museums. They all specialize in various topics related to the Croatian art history in period from the 19th to the 21st century: painting, sculpture, architecture, visual communication, history of art history and, museology. One third of the team (5 researchers) is made up of young researchers for whose development this project can be of utmost importance. During the implementation of the project, it is planned to employ one PhD student.]]></summary_en></project><project>
<id>18663</id><title_hr><![CDATA[NAVIGATE: Život mladih nakon izlaska iz skrbi - longitudinalno istraživanje otpornosti i ranjivosti]]></title_hr><title_en><![CDATA[NAVIGATE: Life of Youth After Leaving Care - A Longitudinal Study of Resilience and Vulnerability]]></title_en><user_id>12728</user_id><user_firstLast_name>Ivana Maurović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2025-02</proposal_call><code>UIP-2025-02-1521</code><acronim><![CDATA[NAVIGATE]]></acronim><duration>01.04.2026 - 31.03.2031</duration><status>U tijeku</status><financ_value>204.273,00 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Edukacijsko-rehabilitacijske znanosti, Socijalne djelatnosti, </scie_field_hr><scie_field_en>Physical education and rehabilitation sciences, Social work, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Edukacijsko-rehabilitacijski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Education and Rehabilitation Sciences]]></institution_en><team_members_id>12719, 12952, 26241, 26867, 870965, 870928, 870972, </team_members_id><team_members_names><![CDATA[Anja Mirosavljević, Gabrijela Ratkajec Gašević, Dinka Caha, Andrea  Ćosić, Barbara Mirković, Sunčana Kusturin, Martina Horvat, ]]></team_members_names><keywords_hr><![CDATA[mladi, izlazak iz skrbi, ranjivost, otpornost, longitudinalno istraživanje]]></keywords_hr><keywords_en><![CDATA[youth, leaving care, vulnerability, resilience, and longitudinal study]]></keywords_en><summary_hr><![CDATA[Mladi koji izlaze iz skrbi izloženi su riziku socijalne isključenosti, beskućništva, nezaposlenosti i mentalnih poteškoća, no neki postižu ishode bolje od očekivanih. Stein (2008) ih dijeli na: otporne, borce i ranjive. U Hrvatskoj nije provedena sustavna analiza njihovih ishoda, što ovaj projekt nadoknađuje praćenjem mladih 18 mjeseci nakon izlaska, analizirajući međuodnos rizičnih i čimbenika otpornosti te uspoređujući mlade iz institucija i udomiteljskih obitelji. Istraživanje se temelji na Socioekološkoj teoriji otpornosti (Ungar, 2012) i Teoriji životnog puta (Elder, 1998). Primjenjuje se longitudinalni sekvencijalni explanatorni mješoviti dizajn s četiri točke mjerenja kvantitativnim pristupom te potom kvalitativnim pristupom putem intervjua s participativnim metodama. Prva faza uključuje validaciju Skale ekološke otpornosti mladih (YERS, van Breda, 2017) s 550 učenika učeničkih domova i provjeru razumijevanja instrumenata s mladima iz skrbi. Longitudinalna faza obuhvaća 200 mladih (18-26 godina) koji izlaze iz skrbi 2026.–2028., uz očekivano sudjelovanje 85 mladih do kraja istraživanja. Kvalitativna faza uključuje 18 mladih podijeljenih prema tipu skrbi i tranzicijskim ishodima (otporni/borci/ranjivi). Instrumenti uključuju upitnike o sociodemografskim obilježjima, nepovoljnim iskustvima u djetinjstvu (ACE; Felitti i sur., 1998), svakodnevnom stresu (Maurović, 2015), čimbenicima otpornosti (YERS, van Breda, 2017) te ishodima poput obrazovanja, zapošljavanja, financijske sigurnosti, NEET statusa, zloupotrebe psihoaktivnih tvari, kriminalnog ponašanja, rane trudnoće/roditeljstva (Dickens, 2016), mentalnog zdravlja (DASS-21; Lovibond i Lovibond, 1995) i zadovoljstva životom (PWI; Cummins i sur., 2003). Kvantitativna analiza uključuje deskriptivnu statistiku, ANOVA-u za ponovljena mjerenja i linearne mješovite modele, a kvalitativna narativnu i tematsku analizu. Znanstveni doprinos projekta je dublje razumijevanje otpornosti i ranjivosti u tranzicijskim ishodima.]]></summary_hr><summary_en><![CDATA[Youth leaving care face risks of social exclusion, homelessness, unemployment, and mental health difficulties, yet some achieve better-than-expected outcomes. Stein (2008) categorizes them as moving-on, survivors, and vulnerable. No systematic analysis of their outcomes has been conducted in Croatia, which this project addresses by tracking youth for 18 months post-care, examining the interplay of risk and resilience factors, and comparing those from residential and foster care. The study is based on the Socio-Ecological Resilience Theory (Ungar, 2012) and Life Course Theory (Elder, 1998). A longitudinal sequential explanatory mixed-methods design is applied, with four quantitative measurement points followed by qualitative approach using interviews and participatory methods. The first phase involves validating the Youth Ecological Resilience Scale (YERS, van Breda, 2017) with 550 dormitory students and testing instrument comprehension with young people from care. The longitudinal phase tracks 200 youth (ages 18–26) leaving care between 2026 and 2028, with an expected retention of 85 participants. The qualitative phase includes 18 young people categorized by care type and transition outcomes (moving-on, survivors, and vulnerable). Instruments assess sociodemographic characteristics, adverse childhood experiences (ACE; Felitti et al., 1998), daily stress (Maurović, 2015), resilience factors (YERS, van Breda, 2017), and outcomes: education, employment, financial security, NEET status, substance abuse, criminal behaviour, early pregnancy/parenthood (Dickens, 2016), mental health (DASS-21; Lovibond & Lovibond, 1995), life satisfaction (PWI; Cummins et al., 2003). Quantitative analysis includes descriptive statistics, repeated-measures ANOVA, and linear mixed models, while qualitative narrative and thematic analysis. The project contributes to scientific knowledge by deepening the understanding of resilience and vulnerability in transition outcomes.]]></summary_en></project><project>
<id>18664</id><title_hr><![CDATA[Promjene u sastavu grožđa i vina uzrokovane opeklinama bobica ]]></title_hr><title_en><![CDATA[Changes in the composition of grapes and wines caused by berry sunburn]]></title_en><user_id>7005</user_id><user_firstLast_name>Marijan Bubola</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-1823</code><acronim><![CDATA[SUNGRAPEADAPT]]></acronim><duration>30.01.2026 - 29.01.2029</duration><status>U tijeku</status><financ_value>198.215,00 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Institut za poljoprivredu i turizam]]></institution_hr><institution_en><![CDATA[Institute of Agriculture and Tourism in Poreč]]></institution_en><team_members_id>4924, 868451, 12576, 868453, 865018, </team_members_id><team_members_names><![CDATA[Igor Lukić, Mario Staver, Marko Karoglan, Paolo Sivilotti, Fumica Orbanić, ]]></team_members_names><keywords_hr><![CDATA[vinova loza, klimatske promjene, opekline od sunca, preventivne mjere, fenolni spojevi, aromatski spojevi ]]></keywords_hr><keywords_en><![CDATA[grapevine, climate change, sunburn, preventive measures, phenolic compounds, aromatic compounds ]]></keywords_en><summary_hr><![CDATA[Opekline od sunca na bobicama vinove loze, posljedični gubici u prinosu te izmijenjen sastav bobica posljednjih godina predstavljaju sve veći izazov u vinogradarskoj proizvodnji, budući da se učestalost njihove pojave povećava kao posljedica klimatskih promjena. Unatoč značajnim ekonomskim gubicima u vinogradarskoj proizvodnji koje one uzrokuju, interes u pogledu njihovog istraživanja je porastao tek posljednjih nekoliko godina te i dalje postoji mnogo nepoznanica i oprečnih informacija o uvjetima pri kojima one nastaju te o tome kako različite vrste opeklina djeluju na sastav i kvalitetu grožđa i vina. Stoga će ciljevi ovog projekta biti istražiti utjecaj pojave različitih vrsta opeklina na sastav i kvalitetu grožđa i vina, uključivši pojedinačne fenolne i aromatske spojeve u grožđu i vinu te deskriptivnu senzornu ocjenu vina, istražiti osjetljivost bobica na pojavu opeklina u različitim fazama razvoja bobice te istražiti mogućnosti prevencije pojave opeklina primjenom navodnjavanja i rane defolijacije. Osjetljivost bobica na pojavu opeklina u raznim fazama razvoja bobice će se utvrditi kako u uvjetima u vinogradu, tako i u uvjetima kontroliranog toplinskog stresa u laboratoriju. S obzirom na predviđeni daljnji porast temperature zraka te veću učestalost toplinskih valova, očekuje se da će se opasnost od pojave opeklina na bobicama povećati u narednim desetljećima, zbog čega će bolje razumijevanje ovog fenomena, kao i istraživanje mogućnosti primjene preventivnih mjera za ublažavanje pojave opeklina omogućiti adekvatnu prilagodbu uzgojnih mjera u vinogradarskoj proizvodnji, umanjujući pritom ekonomske gubitke koje opekline mogu uzrokovati.]]></summary_hr><summary_en><![CDATA[Sunburn damage on grapevine berries and the resulting yield losses, as well as the altered composition of berries, in recent years pose an increasing challenge in viticultural production, as the frequency of their occurrence rises due to climate change. Despite the significant economic losses that they cause in viticultural production, interest in their research has increased only in the past few years, and there are still many uncertain and conflicting information regarding the conditions which influence their occurrence and the effect of different types of sunburn on the composition and quality of grapes and wine. Therefore, the objectives of this project are to investigate the impact of various types of sunburn on the composition and quality of grapes and wine, including the individual phenolic and aromatic compounds in berries and wine, and the sensory descriptive analysis of wines, to investigate the sensitivity of berries to sunburn at different stages of berry development and to investigate the possibilities of preventing sunburn by irrigation and early leaf removal. The sensitivity of berries to sunburn at various stages of berry development will be determined both in vineyard conditions and under controlled heat stress conditions in the laboratory. Given the projected further increase in air temperature and the greater frequency of heatwaves, the risk of sunburn on berries is predicted to increase in the coming decades. Therefore, better understanding of this phenomenon, as well as the investigation of the possibilities to implement preventive measures to mitigate sunburn will enable adequate adaptation of cultivation practices in viticultural production, thereby reducing the economic losses that sunburn can cause.]]></summary_en></project><project>
<id>18666</id><title_hr><![CDATA[Zajednice gljiva uzročnika plavila drva u domaćim i invazivnim populacijama borovih potkornjaka]]></title_hr><title_en><![CDATA[Blue-Stain Fungal Communities in Domestic and Invasive Pine Bark Beetle Populations]]></title_en><user_id>23822</user_id><user_firstLast_name>Marta Kovač</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2025-02</proposal_call><code>UIP-2025-02-9329</code><acronim><![CDATA[BLUSTA-COM]]></acronim><duration>05.12.2025 - 04.12.2030</duration><status>U tijeku</status><financ_value>150.750,00 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Šumarstvo, Interdisciplinarne biotehničke znanosti, </scie_field_hr><scie_field_en>Forestry, Interdisciplinary biotechnical sciences, </scie_field_en><institution_hr><![CDATA[Hrvatski šumarski institut]]></institution_hr><institution_en><![CDATA[Croatian Forest Research Institute]]></institution_en><team_members_id>870871, 19025, 871024, 871022, 870948, 871021, </team_members_id><team_members_names><![CDATA[Markus Wilken, Jelena Kranjec Orlović, Tomislav Krcivoj, Anda Marijanović, Nam Pham, Ida Volenec, ]]></team_members_names><keywords_hr><![CDATA[gljive plavila, potkornjaci, alepski bor, patogenost, filogenija, genetska populacija]]></keywords_hr><keywords_en><![CDATA[blue-stain fungi, bark beetles, Aleppo pine, pathogenicity, phylogeny, genetic population]]></keywords_en><summary_hr><![CDATA[Gljive plavila (Ascomycota) vrste su koje uzrokuju obojenje bjeljike drva kod brojnih vrsta drveća, a najčešće su povezane s potkornjacima (Coleoptera: Curculionidae: Scolytinae) s kojima stvaraju složene simbiotske odnose, a koji služe kao njihovi vektori. Najčešća skupina su ofiostomatoidne gljive od kojih neke vrste mogu biti patogeni na drveću. Mediteranski potkornjak Orthotomicus erosus Wollaston koji je odnedavno postao ozbiljan štetnik na borovima u mediteranskom dijelu Hrvatske, kao i borov potkornjak Hylurgus ligniperda (Fabricius, 1787) povezani su s nekoliko vrsta ofiostomatoidnih gljiva, no patogenost identificiranih vrsta nikada do sada nije istraživana. Također, ove gljive zajedno sa svojim vektorima potkornjacima proširile su se izvan svog prirodnog areala (Europa), gdje predstavljaju ozbiljnu prijetnju neautohtonim borovim šumama. Osim ispitivanja patogenosti već postojećih vrsta ovih gljiva te identificiranja novih prisutnih vrsta, predmet ovog istraživanja je i usporedba populacija ovih gljiva u njihovom domaćem i alohtonom (invazivnom) arealu, te dublje razumijevanje kako su te vrste evoluirale kroz genetske promjene, te kako su zajedno sa svojim vektorima koinvadirale u druga područja.]]></summary_hr><summary_en><![CDATA[Blue-stain fungi (Ascomycota) are species that cause discoloration of the sapwood in various tree species and are most commonly associated with bark beetles (Coleoptera: Curculionidae: Scolytinae), with whom they form complex symbiotic relationships, and these beetles serve as their vectors. The most common group are ophiostomatoid fungi, some species of which can be pathogens to trees. The Mediterranean bark beetle Orthotomicus erosus Wollaston, which has recently become a serious pest on pines in the Mediterranean part of Croatia, as well as the pine bark beetle Hylurgus ligniperda (Fabricius, 1787), are associated with several species of ophiostomatoid fungi, but the pathogenicity of the identified species has never been investigated. Additionally, these fungi, along with their bark beetle vectors, have spread beyond their native range (Europe), where they pose a serious threat to non-native pine forests. In addition to investigating the pathogenicity of already existing species of these fungi and identifying new species present, the aim of this research is to compare populations of these fungi in their native and invasive ranges, and to gain a deeper understanding of how these species have evolved through genetic changes, and how they have co-invaded new areas along with their vectors.]]></summary_en></project><project>
<id>18668</id><title_hr><![CDATA[Stvaranje sinergije u proširenim zemljama na temu upravljanja niskonaponskom mrežom - SynGRID]]></title_hr><title_en><![CDATA[]]></title_en><user_id>20526</user_id><user_firstLast_name>Damir Šljivac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-8476</code><acronim><![CDATA[]]></acronim><duration>01.01.2026 - 31.12.2031</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera Osijek, Fakultet elektrotehnike, računarstva i informacijskih tehnologija Osijek]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Electrical Engineering, Computer Science and Information Technology Osijek]]></institution_en><team_members_id>873009</team_members_id><team_members_names><![CDATA[ Doktorand: Tomislav Markotić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>18671</id><title_hr><![CDATA[Primjena virtualne stvarnosti u školovanju i edukaciji prometnih pilota]]></title_hr><title_en><![CDATA[Application of Virtual reality in Airline pilot Training and Education]]></title_en><user_id>867929</user_id><user_firstLast_name>Petar Andraši</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2025-02</proposal_call><code>UIP-2025-02-9224</code><acronim><![CDATA[AViATE]]></acronim><duration>01.04.2026 - 31.03.2031</duration><status>U tijeku</status><financ_value>279.025,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Tehnologija prometa i transport, Zrakoplovstvo, raketna i svemirska tehnika, </scie_field_hr><scie_field_en>Transport technology, Aerospace, missile and space engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet prometnih znanosti]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Transport and Traffic Sciences]]></institution_en><team_members_id>870970, 866768, </team_members_id><team_members_names><![CDATA[Maja Ozmec-Ban, Bruno Antulov-Fantulin, ]]></team_members_names><keywords_hr><![CDATA[Virtualna stvarnost, školovanje pilota, zrakoplovstvo, simulator leta, integracija tehnologija]]></keywords_hr><keywords_en><![CDATA[Virtual reality, pilot training, aviation, flight simulator, technology integration]]></keywords_en><summary_hr><![CDATA[Projekt istražuje mogućnost integracije VR tehnologije u obuku pilota s ciljem poboljšanja pripremnih i post-operativnih faza letačke obuke. Prethodna istraživanja potvrđuju da VR simulatori imaju potencijal, ali je potrebno utvrditi njihovu dugoročnu učinkovitost i optimalne faze primjene.Za potrebe projekta će se izraditi VR simulator integracijom komercijalno dostupnih komponenti: za vizualizaciju će se koristiti VR naočale,softver simulatora leta, fizičke upravljačke komande. Trenutno postoji funkcionalni prototip simulatora, ali zahtijeva unapređenje računalne opreme i implementaciju miješane stvarnosti (putem OpenXR ili SimXR) kako bi se omogućilo ispravno prikazivanje upravljačkih komandi.Kandidati za eksperiment bit će studenti preddiplomskog programa Aeronautike, u broju od 40 do 50 dobi između 19 i 24 godine. Studenti će biti podijeljeni u dvije skupine: testnu i kontrolnu skupinu. Testna skupina će u pripremi i post-analizi leta koristiti VR okruženje dok će kontrolna skupina koristiti tradicionalne metode (verbalna komunikacija s instruktorom i fizički modele zrakoplova). Nakon pripreme, obje skupine će izvesti let, a uspješnost će se mjeriti odstupanjima zrakoplova od zadane putanje, razlikom u ocjenama instruktora i razlikom u razini procjenjenog stresa.Tijekom eksperimenta prikupljat će se različiti podaci: subjektivne ocjene instruktora (prema ICAO kompetencijama), GNSS zapisi o kretanju i stanju zrakoplova, biometrijski podaci (mjerenje srčane frekvencije i varijabilnosti, te procjena psihičkog opterećenja putem NASA TLX obrasca) te video i audio zapisi iz pilotske kabine. Dobiveni podaci analizirat će se statističkim metodama (T-test, ANOVA, regresijska analiza) kako bi se usporedile performanse između skupina.Glavna hipoteza istraživanja je da integracijom VR tehnologije u obuku pilota dolazi do bržeg savladavanja programa, smanjenja broja pogrešaka i nižeg psihičkog opterećenja, što može rezultirati i ekonomskim te ekološkim beneficijama.]]></summary_hr><summary_en><![CDATA[The project explores the potential integration of VR technology into pilot training to enhance the briefing and debriefing phases of flight training. Previous research confirms that VR simulators possess significant potential; however, it is necessary to determine their long-term effectiveness and the optimal phases for their application.A VR simulator will be developed by integrating commercially available components: VR headsets, flight simulator software, and physical flight controls. Although there is a functional prototype, upgrades to the computer hardware with the implementation of mixed reality are required to enable an accurate effect of flight controls.Candidates in the experiment will be students from the undergraduate Aeronautics program, numbering between 40 and 50, aged 19 to 24. The students will be divided into two groups: a test group and a control group. The test group will use a VR environment for flight briefing and debriefing, whereas the control group will employ traditional methods (verbal communication and physical aircraft models). After the briefing, both groups will conduct a flight. The success rate will be measured by deviations from the designated flight path, differences in the instructors’ scores, and differences in the levels of stress.Various data will be collected: subjective evaluations by the flight instructors (based on ICAO competencies), GNSS records of the aircraft’s movement and attitude, biometric data (heart rate (HR) and HR variability, mental workload from NASA TLX form), and video and audio recordings. The obtained data will be analyzed using statistical methods (T-test, ANOVA, regression analysis) to compare the performance between the groups.The research hypothesises is that the integration of VR technology into the pilot training will lead to faster mastery of the training program, a reduction in the number of errors as well a lowered mental workload, which may also result in economic and environmental benefits.]]></summary_en></project><project>
<id>18673</id><title_hr><![CDATA[Powering the METAmorphosis of BUILDings towards a decarbonised and sustainable energy system (META BUILD)]]></title_hr><title_en><![CDATA[]]></title_en><user_id>13036</user_id><user_firstLast_name>Tomislav Pukšec</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-7703</code><acronim><![CDATA[]]></acronim><duration>23.01.2026 - 18.02.2030</duration><status>U tijeku</status><financ_value>49,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, </scie_field_hr><scie_field_en>Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>871066</team_members_id><team_members_names><![CDATA[ Doktorand: Luka Simić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>18674</id><title_hr><![CDATA[Digitalni blizanac i GIS optimizacija zasnovani na umjetnoj inteligenciji za napredne centralizirane toplinske sustave ]]></title_hr><title_en><![CDATA[AI-Driven Digital Twin and GIS Optimization for Advanced District Heating Systems]]></title_en><user_id>13036</user_id><user_firstLast_name>Tomislav Pukšec</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-6488</code><acronim><![CDATA[AI-DTDH]]></acronim><duration>05.12.2025 - 04.12.2028</duration><status>U tijeku</status><financ_value>199.790,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, </scie_field_hr><scie_field_en>Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>871066, 858327, 865155, 868518, 20485, </team_members_id><team_members_names><![CDATA[Luka Simić, Ana Kodba, Josip Miškić, Henning Meschede, Henrik Lund, ]]></team_members_names><keywords_hr><![CDATA[Digitalni blizanac, prediktivno održavanje, GIS optimizacija, centralizirani toplinski sustavi, strojno učenje]]></keywords_hr><keywords_en><![CDATA[Digital Twin, Predictive Maintenance, GIS Optimization, District Heating, Machine Learning]]></keywords_en><summary_hr><![CDATA[Projekt AI-DTDH ima za cilj poboljšati učinkovitost, održivost i pouzdanost centraliziranih toplinskih sustava (DH) kroz integraciju modeliranja digitalnog blizanca, AI-pokretanog prediktivnog održavanja i GIS-temeljene prostorne optimizacije. Projekt će razviti sveobuhvatan podatkovni okvir integriranjem GIS slojeva, podataka senzora i meteoroloških zapisa kako bi se stvorio objedinjeni skup podataka. Višerazinski digitalni blizanac bit će dizajniran pomoću simulacijskih platformi za replikaciju dinamičkog ponašanja sustava. Kako bi se poboljšalo planiranje infrastrukture, koristit će se GIS i višekriterijska analiza odlučivanja (MCDA) za optimizaciju mreža distribucije topline i planiranje trase cjevovoda. Osim toga, razvit će se AI-pokretani modeli prediktivnog održavanja pomoću algoritama strojnog učenja (npr. LSTM mreža) kako bi se predvidjeli kvarovi sustava, detektirali nedostaci i poboljšala operativna učinkovitost. Projekt će validirati svoje metodologije kroz pilot studiju u stvarnim uvjetima, implementirajući IoT-opremljene DH instalacije za procjenu performansi sustava u različitim operativnim uvjetima, uključujući miješanje alternativnih goriva. Eksperimentalni rezultati omogućit će dodatnu prilagodbu digitalnog blizanca i AI modela, čime će se osigurati njihova praktična primjenjivost za industrijsku upotrebu. Ovaj interdisciplinarni pristup rezultirat će energetski učinkovitijim, ekonomičnijim i otpornijim mrežama daljinskog grijanja, smanjenjem troškova održavanja te poboljšanjem održivosti urbanih sredina. Rezultati projekta pružit će podršku donositeljima odluka, energetskim tvrtkama i urbanim planerima u optimizaciji buduće infrastrukture daljinskog grijanja kroz analizu temeljenu na stvarnim i realnim podacima.]]></summary_hr><summary_en><![CDATA[AI-DTDH project aims to enhance the efficiency, sustainability, and reliability of district heating (DH) systems by integrating digital twin modeling, AI-driven predictive maintenance, and GIS-based spatial optimization. The project will develop a comprehensive data framework by integrating GIS layers, sensor outputs, and meteorological records to create a unified dataset. A multi-scale digital twin will be designed using simulation platforms to replicate dynamic system behaviour. To improve infrastructure planning, GIS and multi-criteria decision analysis (MCDA) will be employed to optimize heat distribution networks and pipeline routing. Additionally, AI-driven predictive maintenance models will be developed using machine learning algorithms (e.g., LSTM networks) to forecast system failures, detect faults, and improve operational efficiency. The project will validate its methodologies through a real-world pilot study, deploying IoT-equipped DH installations to assess system performance under varying operational conditions, including alternative fuel blending. The experimental results will refine the digital twin and AI models, ensuring practical applicability for industry adoption. This interdisciplinary approach will lead to more energy-efficient, cost-effective, and resilient DH networks, reducing maintenance costs and enhancing urban sustainability. The outcomes will support policymakers, energy providers, and urban planners in optimizing future DH infrastructure with data-driven insights.]]></summary_en></project><project>
<id>18680</id><title_hr><![CDATA[Sustainable Healthcare with Digital Health Data Competence (SUSA)]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5393</user_id><user_firstLast_name>Sven Lončarić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-5537</code><acronim><![CDATA[]]></acronim><duration>13.12.2025 - 12.12.2031</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>872721</team_members_id><team_members_names><![CDATA[ Doktorand: Stella Balić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>18683</id><title_hr><![CDATA[Danube Ruralscapes - A Network of Professional Support for Self-organized Village Clusters Achieving Sustainable Heritage-based Ruralscapes ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5206</user_id><user_firstLast_name>Dina Stober</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-6072</code><acronim><![CDATA[]]></acronim><duration>01.01.2026 - 02.01.2032</duration><status>Završio</status><financ_value>72,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Arhitektura i urbanizam, </scie_field_hr><scie_field_en>Architecture and Urban Environment, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Građevinski i arhitektonski fakultet Osijek]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Civil Engineering and Architecture Osijek]]></institution_en><team_members_id>872975</team_members_id><team_members_names><![CDATA[ Doktorand: Marko Ganjto ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>18686</id><title_hr><![CDATA[Urinarni kateteri obloženi s antimikrobnim peptidima za suzbijanje bakterijskih infekcija]]></title_hr><title_en><![CDATA[Urinary catheters coated with antimicrobial peptides for prevention of bacterial infections]]></title_en><user_id>17844</user_id><user_firstLast_name>Tomislav Rončević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2025-02</proposal_call><code>UIP-2025-02-8124</code><acronim><![CDATA[UROPEP]]></acronim><duration>01.04.2026 - 31.03.2031</duration><status>U tijeku</status><financ_value>297.650,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, Fizika, Interdisciplinarne prirodne znanosti, </scie_field_hr><scie_field_en>Biology, Physics, Interdisciplinary natural sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Science]]></institution_en><team_members_id>19982, 25707, </team_members_id><team_members_names><![CDATA[Željana Fredotović, Matko Males, ]]></team_members_names><keywords_hr><![CDATA[Antimikrobni peptidi (AMP), multirezistentne bakterije, membranolitički AMP, urinarne infekcije, oblaganje katetera]]></keywords_hr><keywords_en><![CDATA[Antimicrobial peptides (AMPs), multi-drug resistant bacteria, membranolytic AMPs, urinary infections, catheter coating]]></keywords_en><summary_hr><![CDATA[U zadnjim desetljećima, infekcije uzrokovane multi-rezistentnim bakterijama postale su gorući zdravstveni problem diljem svijeta s desecima milijuna inficiranih i milijunima preminulih osoba svake godine. Urinarne infekcije godišnje uzimaju otprilike 230 000 života dok >400 000 000 ljudi bude zaraženo diljem svijeta. Prema podacima CDC-a (Centre for Disease Control) 75% urinarnih infekcija stečenih u bolnici događa se putem uporabe urinarnih katetera (CAUTI, catheter-associated urinary tract infections), a isti podaci govore da je kod 15-25% hospitaliziranih pacijenata nužna uporaba urinarnih katetera. Klasični antibiotici gube bitku s rastućom bakterijskom rezistencijom koja zahtijeva pronalazak novih klasa lijekova s alternativnim mehanizmom djelovanja. U tom kontekstu često su istraživani antimikrobni peptidi (AMP-i) jer pokazuju direktnu antimikrobnu aktivnost naspram gram-negativnih i gram-pozitivnih bakterija, uključujući i multirezistentne bakterijske izolate, dok istovremeno nisu zabilježeni slučajevi razvoja dugoročne rezistencije. CAUTI predstavljaju veliki zdravstveni problem i različite istraživačke skupine pokušavaju razviti nove klase urinarnih katetera, često obloženih bioaktivnim komponentama, kako bi spriječile takve infekcije. Unutar ovog projekta identificirat ćemo nove peptide, testirati njihovu antimikrobnu aktivnost, toksičnost i način djelovanja koristeći biofizikalne eksperimente i molekularno modeliranje. Peptidi s najpovoljnijim karakteristikama će se odabrati za oblaganje katetera s ciljem sprječavanja ili minimiziranja infekcija izravnim kontaktnim ubijanjem ili kontroliranim otpuštanjem peptida. To će zahtijevati razvoj novih eksperimentalnih i teorijskih pristupa kako bi se osigurali uspješni postupci oblaganja i razvoj novih katetera s poboljšanim karakteristikama.]]></summary_hr><summary_en><![CDATA[In recent decades, infections caused by multi-drug resistant bacteria have become a surging health problem worldwide responsible for tens of millions of infections and millions of deaths each year. Urinary tract infections annually claim approximately 230 000 lives while >400 000 000 people are infected worldwide. According to data from the CDC (Centre for Disease Control), 75% of urinary infections acquired in hospitals occur through the use of urinary catheters (CAUTI, catheter-associated urinary tract infections), and the same data indicate that 15-25% of hospitalized patients require the use of urinary catheters. Classical antibiotics are losing the battle with growing bacterial resistance, emphasizing the need for novel anti-infective drugs with alternative modes of action. Antimicrobial peptides (AMPs) are often considered in this regard as they have direct antimicrobial activity against Gram-negative and Gram-positive bacteria, including multiresistant bacterial isolates while at the same time no cases of long-term resistance were observed.CAUTIs are a major health problem and different research groups are trying to develop novel classes of urinary catheters, often coated with bioactive components, to prevent such infections. Within this project we will identify novel peptides, test their antimicrobial potency, toxicity and the mode of action using biophysical experiments and molecular modelling. AMPs with the most favourable characteristics will be selected for catheter coating to prevent or minimize infections through direct contact killing or through controlled release of peptides. This will require development of novel experimental and theoretical methodologies to ensure successful coating procedures and development of new catheters with improved characteristics.   ]]></summary_en></project><project>
<id>18699</id><title_hr><![CDATA[Utjecaj prehrane na učinak intranazalnog inzulina na kogniciju u štakorskoga modela sporadične Alzheimerove bolesti]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3079</user_id><user_firstLast_name>Jelena Osmanović Barilar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-5472</code><acronim><![CDATA[AD-INdiet]]></acronim><duration>15.11.2025 - 14.11.2031</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>872898</team_members_id><team_members_names><![CDATA[ Doktorand: Luka Mihalic ]]></team_members_names><keywords_hr><![CDATA[Alzheimerova bolest, intranazalni inzulin, kognicija, prehrana bogata mastima, inzulinska rezistencija ]]></keywords_hr><keywords_en><![CDATA[Alzheimer&#39;s disease, intranasal insulin, cognition, high-fat diet, insulin resistance ]]></keywords_en><summary_hr><![CDATA[Poremećaj inzulinske signalizacije povezan je s mnogim neurodegenerativnim bolestima, uključujući Alzheimerovu bolest (AD). Smatrano je da su neuroni neovisni o inzulinu, ali nove spoznaje upućuju na ulogu inzulina u metabolizmu glukoze u mozgu. Sve više dokaza pokazuje da su inzulinska rezistencija i metabolička disfunkcija posrednici AD-a, što dodatno karakterizira AD kao središnju metaboličku bolest posredovanu inzulinskom rezistencijom u mozgu (IRBS). Terapijski potencijal intranazalnog (IN) inzulina u liječenju AD-a ispitivan je u kliničkim studijama te je, načelno,  nađeno a kognitivno poboljšanje ali u nekoliko studija IN inzulin nije imaopovoljni učinak, moguće kao posljedica još nejasnih molekularnih mehanizama središnjih učinaka inzulina i njegove distribucije nakon IN primjene. Cilj projekta je istražiti središnju i perifernu distribuciju akutnog IN inzulina ovisno o vremenu i dozi. Nadalje, obzirom da je prehrana jedna od ključnih komponenti u razvoju metaboličkog sindroma (čimbenik rizika za AD), učinci IN inzulina na kogniciju mogli bi ovisiti o prehrani. Streptozotocin (STZ) se koristi u pretkliničkim istraživanjima za induciranje dijabetes mellitusa u životinja nakon periferne primjene visokih doza te za induciranje IRBS i posljedično sporadičnog oblika AD (sAD), intracerebroventrikularnom (icv) primjenom malih doza. Dodatno, projekt ima za cilj istražiti utjecaj prehrane na učinak IN inzulina na kogniciju (prehrana s visokim udjelom masti) u STZ-icv modelu sAD-a. Rezultati projekta proširit će znanje o čimbenicima koji utječu na terapijski potencijal IN inzulina, u ovisnosti o stadiju sAD-a i prehrani životinja te pružiti informacije o translaciji rezultata sa životinja na čovjeka i prilagodbi doze inzulina ovisno o metaboličkom statusu pacijenta. Budući da IRBS može biti u pozadini i drugih bolesti, razjašnjenje terapijskog potencijala IN inzulina od velike je važnosti za neurofarmakologiju.]]></summary_hr><summary_en><![CDATA[Impaired response to insulin has been linked to many neurodegenerative disorders including Alzheimer’s disease (AD). Neurons have been considered to be independent of insulin, but emerging evidence suggests that insulin has a role in glucose metabolism in the brain. A growing body of evidence indicates that insulin resistance and metabolic dysfunction are mediators of AD, proposing AD as a central metabolic disease mediated by insulin resistant brain state (IRBS). Therapeutic potential of intranasal (IN) insulin in AD has already been in the focus of many clinical trials, demonstrating, in general, an enhancement of memory performance but in few studies, IN insulin had no beneficial effects, which could be due to yet unclear molecular mechanisms of the central insulin effect and its distribution after IN administration. The project aims to investigate central and peripheral distribution of acutely administered IN insulin in time- and dose-dependent manner. Furthermore, since diet is one of the crucial components in development of metabolic syndrome (risk factor for AD), the effects of IN insulin on cognition could depend on the diet. Streptozotocin (STZ) is wildly used in preclinical research to induce diabetes mellitus in animals when given peripherally in high dose, and to induce IRBS and consequently the sporadic AD (sAD), when given intracerebroventricularly (icv) in small doses. The project also aims to explore the diet-conditioned (high-fat diet) effect of IN insulin on cognition in a STZ-icv rat model of sAD. The project results will enlarge the knowledge on the factors affecting the therapeutic potential of IN insulin, particularly the stage of sAD and animal diet, and provide a valuable information on animal-to-human translation and treatment corrections depending on patient metabolic status. Since IRBS may underlay diseases other than AD, elucidation of the therapeutic potential of IN insulin is of great importance for modern neuropharmacology.]]></summary_en></project><project>
<id>18703</id><title_hr><![CDATA[Klimatsko modeliranje na konvektivnoj skali za područje Hrvatske: ekstremi oborine i razine mora]]></title_hr><title_en><![CDATA[]]></title_en><user_id>21139</user_id><user_firstLast_name>Danijel Belušić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-2209</code><acronim><![CDATA[C3PO]]></acronim><duration>09.02.2026 - 08.02.2032</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Geofizika, </scie_field_hr><scie_field_en>Geophysics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>873044</team_members_id><team_members_names><![CDATA[ Doktorand: Marin Belamarić ]]></team_members_names><keywords_hr><![CDATA[modeli konvektivne skale, simulacije događaja na visokoj rezoluciji, klimatski ekstremi, ekstremna oborina, obalno poplavljivanje]]></keywords_hr><keywords_en><![CDATA[Convection permitting models, event-based downscaling, climate extremes, extreme precipitation, coastal flooding]]></keywords_en><summary_hr><![CDATA[Klimatski i vremenski ekstremi postaju sve jači i učestaliji u mnogim regijama kao posljedica globalnih klimatskih promjena. Jedini dostupni alati za procjenu budućih promjena ekstrema su klimatski modeli. Iako najsuvremeniji klimatski modeli mogu reproducirati neke od ekstrema, postoji velika skupina događaja koji se ne mogu ispravno simulirati, kao što su ekstremne oborine ili lokalne oluje. Ovaj projekt koristi novu generaciju klimatskih modela, koji se nazivaju modeli dopuštanja konvekcije, kako bi se značajno poboljšala reprodukcija ekstrema, s posebnom dodanom vrijednošću za ekstremne oborine i lokalne događaje kao što su urbani toplinski valovi i planinski vjetrovi. Ovi se modeli sve više koriste u istraživanju i primjeni jer je ovo prvi put da klimatski modeli mogu dati realnu procjenu budućih promjena ekstremnih oborina. Međutim, ovi modeli zahtijevaju previše računalnih resursa da bi se koristili kao alati za pružanje klimatskih informacija korisnicima i dionicima. To je zato što je važna komponenta informacija o klimatskim promjenama procjena nesigurnosti, koja zahtijeva veliki skup pojedinačnih simulacija. U ovom projektu nudimo zaobilaženje ove prepreke razvijanjem metodologije za klimatske simulacije samo specifičnih kratkotrajnih ekstremnih događaja, što može smanjiti računalne troškove za oko 50 puta i tako osloboditi dovoljno resursa za ispravnu procjenu nesigurnosti. Kao rezultat toga, ovaj projekt (i) uvodi novu generaciju klimatskih modela kao zajednički alat za hrvatska klimatska istraživanja i primjene, (ii) kombinira akademske, operativne i korisnički orijentirane aktivnosti u zajednički i međunarodno konkurentan okvir, i (iii) nudi inovativna i općenita rješenja za primjene ovih modela u studijama procjene utjecaja i rizika za različite dionike kao što su urbanisti i upravna tijela.]]></summary_hr><summary_en><![CDATA[Climate and weather extremes are increasing in strength and frequency in many regions following the global climate change. The only available tools for assessing future changes of extremes are climate models. While the state-of-the-art climate models can reproduce some of the extremes, there is a large group of events that cannot be properly simulated, such as extreme precipitation or local windstorms. This project uses the new generation of climate models, called convection permitting models, to make a step improvement in reproducing extremes, with particular added value for extreme precipitation and local events such as urban heat waves and mountain wind systems. These models are being increasingly used in research and applications because this is the first time that climate models can give realistic assessment of future changes of extreme precipitation. However, these models are prohibitively computationally expensive to be used as tools for offering proper climate information to users and stakeholders. This is because an important component of climate change information is an estimation of uncertainty, which requires a large ensemble of individual simulations. In this project we offer to circumvent this hurdle by developing a methodology for climate simulations of only specific short-lived extreme events, which can decrease the computational cost by about 50 times and thus release enough resources for proper uncertainty estimate. As a result, this project (i) introduces the new generation of climate models as a common tool for the Croatian climate research and applications, (ii) combines academic, operational and user-oriented activities into a common and internationally-competitive framework, and (iii) offers innovative and general solutions for user-tailored applications of these models in impact and risk assessment studies for various stakeholders such as urban developers and policy makers.]]></summary_en></project><project>
<id>18706</id><title_hr><![CDATA[Pouzdane metode za proračun aluminijskih konstrukcija koje odgovaraju zahtjevima budućnosti]]></title_hr><title_en><![CDATA[]]></title_en><user_id>369</user_id><user_firstLast_name>Davor Skejić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-2279</code><acronim><![CDATA[REAL-fit]]></acronim><duration>19.01.2026 - 18.01.2032</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Građevinarstvo, </scie_field_hr><scie_field_en>Civil engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Građevinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Civil Engineering]]></institution_en><team_members_id>873008</team_members_id><team_members_names><![CDATA[ Doktorand: Marko Antić ]]></team_members_names><keywords_hr><![CDATA[aluminijske konstrukcije, robotsko zavarivanje, Eurokod 9, pouzdanost, Direktna metoda proračuna, optimizacija, analiza životnog ciklusa, održivost]]></keywords_hr><keywords_en><![CDATA[aluminium structures, robotic welding, Eurocode 9, reliability, Direct Design Method, optimisation, life-cycle analysis, sustainability]]></keywords_en><summary_hr><![CDATA[Iako konstrukcijske aluminijske legure obiluju prednostima u odnosu na druge građevinske materijale (mala vlastita težina, korozijska otpornost, 100% mogućnost reciklaže), uz njih se vežu pretežito konzervativne proračunske metode dane u Eurokodu 9. Konzervativne redukcije mehaničkih svojstava aluminija u zoni zavarenog spoja imaju za posljedicu izbjegavanje upotrebe zavarenih elemenata što značajno ograničava primjenu aluminija u nosivim građevinskim konstrukcijama. Naime, kod konstrukcija većih raspona nužne su velike dimenzije elemenata koji se ne mogu proizvesti istiskivanjem. Nadalje, uporaba istisnutih aluminijskih elemenata ne omogućuje racionalizaciju utroška materijala kao što se to može ostvariti zavarenim elementima promjenjive visine koji se ciljano oblikuju prema funkciji u konstrukcijskom sustavu. U tom smislu, projekt REAL-fit predlaže sveobuhvatna interdisciplinarna istraživanja mogućnosti primjene inovativnih tehnologija robotske proizvodnje i pouzdanih metoda proračuna aluminijskih zavarenih elemenata, priključaka i čitavih konstrukcijskih sustava. Planirani razvoj optimiziranog postupka robotskog zavarivanja biti će baza za istraživanje konstrukcijskog ponašanja zavarenih aluminijskih elemenata i priključaka nosač-stup. Osim eksperimentalnih i numeričkih metoda, u istraživanju će se koristi probabilističke metode. Probabilističke analize na II. razini omogućit će znanstveno argumentirano poboljšanje proračunskih postupaka danih u europskim normama za proračun aluminijskih konstrukcija. Nadalje, izazovi primjene aluminijskih legura u građevinarstvu rješavat će se holističkim pristupom koji integrira naprednu Direktnu metodu proračuna konstrukcija s metodama procjene životnog ciklusa i analize troškova životnog ciklusa. Upravo to je jedan od krajnjih ciljeva projekta s kojim će se vrednovati pouzdanost i održivost ekonomičnih aluminijskih konstrukcija tijekom cijelog životnog vijeka.]]></summary_hr><summary_en><![CDATA[Although structural aluminium alloys have many advantages compared to other construction materials (low self-weight, corrosion resistance, 100% recyclable), they are associated with predominantly conservative design methods given in Eurocode 9. Conservative reductions of aluminium mechanical properties in the welded connection zone have the effect of avoiding the use of welded members, which significantly limits the use of aluminium in load-bearing structures. This is because structures with larger spans require large dimensions of the members, which cannot be produced by extrusion. Moreover, the use of extruded aluminium members does not allow for rationalisation of material consumption, as can be achieved with welded tapered members that are specifically shaped according to their function in the structural system. In this sense, the REAL-fit project proposes comprehensive interdisciplinary research on the possibility of applying innovative robotic production technologies and reliable design methods for aluminium welded members, joints, and entire structural systems. The planned development of an optimised robotic welding process will form the basis for research into the structural behaviour of welded aluminium members and beam-to-column joints. In addition to experimental and numerical methods, probabilistic methods will also be used in the research. 2nd order probabilistic analyses will enable a scientifically based improvement of the design procedures given in the European norms for the design of aluminium structures. Furthermore, the challenges of the application of aluminium alloys in construction will be solved with a holistic approach that integrates the advanced Direct Design Method of structural design with the methods of life-cycle assessment and life-cycle cost analysis. This is precisely one of the ultimate goals of the project, which will evaluate the reliability and sustainability of economic aluminium structures throughout their life cycle.]]></summary_en></project><project>
<id>18707</id><title_hr><![CDATA[Utjecaj m6A RNA epitranskriptomskih modifikacija na metaboličke putove povezane s ovisnošću]]></title_hr><title_en><![CDATA[Influence of m6A RNA Epitranscriptomics Modifications in Addiction-Associated Metabolic Pathw ays]]></title_en><user_id>4624</user_id><user_firstLast_name>Ana Filošević Vujnović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2025-02</proposal_call><code>UIP-2025-02-3285</code><acronim><![CDATA[M6A-META- AD]]></acronim><duration>01.04.2026 - 31.03.2031</duration><status>U tijeku</status><financ_value>300.000,00 eur</financ_value><scie_area_hr>Interdisciplinarno područje znanosti</scie_area_hr><scie_area_en>Interdisciplinary scientific area</scie_area_en><scie_field_hr>Biotehnologija u biomedicini, </scie_field_hr><scie_field_en>Biotechnology in Biomedicine, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Fakultet biotehnologije i razvoja lijekova]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Biotechnology and Drug Development]]></institution_en><team_members_id>22579, 604, 855438, </team_members_id><team_members_names><![CDATA[Paula Žurga, Marin Dominović, Milan Petrović, ]]></team_members_names><keywords_hr><![CDATA[m6A RNA modifikacije, neurometabolizam, razvoj ovisnosti, Drosophila melanogaster, metamfetamin, epitranskriptomika]]></keywords_hr><keywords_en><![CDATA[m6A RNA modifications, neurometabolism, development of addiction, Drosophila melanogaster, methamphetamine, epitranscriptomics]]></keywords_en><summary_hr><![CDATA[Epitranskriptomske modifikacije, poput N6-metiladenozina (m6A), ključne su u regulaciji ekspresije gena, dok su u kontekstu ovisnosti i razvoja ovisnosti relativno ne istražene. Metamfetamin (METH) izaziva promjene u staničnom metabolizmu, mitohondrijsku disfunkciju i preraspodjelu energetskih izvora, što može utjecati na stabilnost i funkciju RNA. Ovaj projekt istražuje kako METH modulira metabolizam im6A RNA modifikacije na modelu Drosophila melanogaster, s ciljem razjašnjavanja njihove međusobne povezanosti. Pritom se otvara novi istraživački smjer koji spaja neurometabolizam i epitranskriptomiku u proučavanju mehanizama ovisnosti.Eksperimentalni dizajn uključuje administraciju METH-a i temporalnu analizu metaboličkih promjena upotrebom spektrometrije mase (HPLC-MS/MS). Razina i distribucija m6A modifikacija proučavat će se metodom m6A mRNA imunoprecipitacijskog sekvenciranja (MeRIP-seq), uz paralelno praćenje ekspresije enzima ključnih za m6A regulaciju. Kako bi se istražila funkcionalna povezanost između metaboličkihpromjena i epitranskriptomske regulacije, koristit će se linije mušica s mutacijama u m6A regulatornim genima (Mettl3, YTHDF,YTHDC). Dodatno, mušice s mutacijama u metaboličkim genima omogućit će ispitivanje utjecaja metaboličkih promjena na m6Amodifikacije. Obzirom na specifične uloge neurona i glijalnih stanica u staničnoj plastičnosti, projekt će definirati u kojoj mjerineuronski i glijalni m6A mehanizmi pridonose promjenama izazvanim METH-om. Rezultati ovog istraživanja doprinijet će razumijevanju utjecaja METH-a na molekularne mehanizme razvoja ovisnosti, dinamiku m6A RNA modifikacija te njihovu povezanost s metaboličkim putevima, potencijalno identificirajući epitranskriptomske biomarkere povezane s neuroplastičnošću i metaboličkom regulacijom. Projekt će postaviti temelje za razvoj nove istraživačke grupe, bazirane na interdisciplinarnome pristupu u razumijevanju epitranskriptomskih mehanizama ovisnosti.]]></summary_hr><summary_en><![CDATA[Epitranscriptomic modifications, such as N6-methyladenosine (m6A), are key regulators of gene expression but remain largely unexplored in addiction. Methamphetamine (METH) disrupts cellular metabolism, causing mitochondrial dysfunction and energy redistribution, which may affect RNA stability and function. This project investigates how METH influences metabolism and m6A RNA modifications in Drosophilamelanogaster, establishing a new research group that integrates neurometabolism and epitranscriptomics in addiction studies. The experimental design includes administration of METH and temporal analysis of metabolic changes using mass spectrometry (HPLC-MS/MS). The level and distribution of m6A modifications w ill be studied using the method of m6A mRNA immunoprecipitation sequencing (MeRIP-seq), with parallel monitoring of the expression of enzymes key to m6A regulation. In order to investigate the functional connection between metabolic changes and epitranscriptomic regulation, fly lines with mutations in m6A regulatory genes (Mettl3, YTHDF, YTHDC)will be used. Additionally, flies with mutations in metabolic genes will allow examination of the impact of metabolic changes on m6A modifications. Given the specific roles of neurons and glial cells in cellular plasticity, the project w ill define to what extent neuronal and glial m6A mechanisms contribute to METH induced changes. The results of this research w ill contribute to the understanding of METH&#39;s influence on the molecular mechanisms of addiction development, the dynamics of m6A RNA modifications and their connection with metabolic pathways, potentially identifying epitranscriptomic biomarkers related to neuroplasticity and metabolic regulation. The project will lay the foundations for the development of a new research group, based on an interdisciplinary approach to understanding theepitranscriptomic mechanisms of addiction.]]></summary_en></project><project>
<id>18719</id><title_hr><![CDATA[Nosivi optički kemijski senzori za multimodalno određivanje biomarkera 		 							 							 							]]></title_hr><title_en><![CDATA[]]></title_en><user_id>12962</user_id><user_firstLast_name>Ivana Steinberg</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-5984</code><acronim><![CDATA[WearSense]]></acronim><duration>11.11.2025 - 10.11.2031</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet kemijskog inženjerstva i tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Chemical Engineering and Technology]]></institution_en><team_members_id>872906</team_members_id><team_members_names><![CDATA[ Doktorand: Ivana Perković ]]></team_members_names><keywords_hr><![CDATA[kemijski senzor, nosivi senzor, biomarker, ionski senzori, nanomaterijali, pH indikatori, fotopletizmografija]]></keywords_hr><keywords_en><![CDATA[chemical sensor, wearable sensor, biomarker, ion sensing, nanomaterials, pH indicators, photoplethysmography]]></keywords_en><summary_hr><![CDATA[Komercijalni nosivi uređaji (fitness trackers) i pametni satovi za praćenje fizioloških parametara koriste optičku detekciju za određivanje otkucaja srca (HR) i varijabilnosti otkucaja srca (HRV) pomoću fotopletizmografije (PPG). Mogućnost integracije (bio)kemijskog optičkog senzora u takve uređaje za istovremeno mjerenje fizičkih i (bio)kemijskih signala putem iste optičke platforme pruža jedinstvenu priliku za inovativno istraživanje. U projektu ćemo implementirati multimodalno određivanje biomarkera kombinirajući fizičke i biokemijske parametre. Razvit ćemo optičke kemijske senzore i metode ekstrakcije signala te algoritme primjenjive na nosive uređaje sljedeće generacije. U znanstvenim  istraživanjima slabo su zastupljeni nosivi optički senzor za kontinuirano praćenje biomarkera u biofluidima. Naša dosadašnjih istraživanja u području kemijskih optičkih senzora uklapaju se u uočeni nedostatak. Tome pripadaju novih optički senzorski materijali  na bazi ionofora, (nano)optoda i prirodno dobivenih pigmenata. Primjenom racionalog  dizajna za  funkcionalizaciju kemijski osjetljivih sučelja koristit će se nosivi  biokompatibilnih (nano)materijali. Integracijom i laboratorijskom karakterizacijom te evaluacijom na elektroničkoj platformi dobit će se mogućnost praćenja fizičkih  parametara (HR, HRV) i odabranih biokemijskih markera  kontinuirano u realnom vremenu. Glavni istraživački tim je sa Sveučilišta u Zagrebu (FKIT i FER) ojačan suradnicima iz Austrije, Švicarske i UK-a. Projekt će omogućit mladim istraživačima obuku u multidisciplinarnom području primijenjenih istraživanja u visoko konkurentnom području nosivih senzora. Glavni rezultat projekta bit će optički kemijski senzori  za praćenje važnih analita iz znoja i intersticijske tekućine. Istraživanja pokrivaju  globalnu problematiku područja nosivih (bio)kemijskih senzora – brzorastućeg, atraktivnog i vrlo izazovnog područja moderne znanosti i tehnologije. ]]></summary_hr><summary_en><![CDATA[Commercial wearable fitness trackers and smartwatches use optical detection for heart rate (HR) and heart rate variability (HRV) determination using photopletysmography (PPG).This provides a unique opportunity for integration of (bio)chemical optical sensing components and simultaneous measurement of physical and chemical signals via the same optical platform. In this project we intend to implement multimodal biomarker determination combining physical and biochemical parameters. We will develop optical chemical sensors and signal extraction methods and algorithms applicable to next generation wearable devices. There is a gap in current research output and in the availability of wearable optical sensors for continuous monitoring of biofluids. To bridge this gap we will use ionophore based optical sensors,(nano)optodes and naturally derived pigments. We are proposing to use an integrated reiterative development methodology that includes new sensor materials development, fabrication technology, and integration with optics. It will involve rational design and scalable fabrication of chemically sensitive interfaces using wearable biocompatible (nano)materials, and their integration on an electronic platform capable of sensing heartbeat parameters (HR, HRV) and biochemical markers in continuous real-time.The project will bring together a core research team from University of Zagreb (FCET and FEEC) strengthened with collaborators from Austria, Switzerland and the UK. This project environment will provide young researchers  training in a multidisciplinary area of applied research in a highly competitive field.The main result of the project will be functional optical chemical sensors each optimised for the determination of important sweat and interstitial fluid (ISF) analytes. In the course of the research, we will address some of the major challenges and in doing so will make a significant contribution to advancing the state-of-the-art. ]]></summary_en></project><project>
<id>18722</id><title_hr><![CDATA[Dekodiranje moždanog glikoma: Ciljano glikoproteomsko istraživanje ljudskog mozga]]></title_hr><title_en><![CDATA[Decoding the brain’s glycome: A targeted glycoproteomic exploration of the human brain]]></title_en><user_id>865331</user_id><user_firstLast_name>Thomas Klarić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-6562</code><acronim><![CDATA[GlycoBrain]]></acronim><duration>26.01.2026 - 25.01.2029</duration><status>U tijeku</status><financ_value>171.117,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, Kemija, </scie_field_hr><scie_field_en>Biology, Chemistry, </scie_field_en><institution_hr><![CDATA[GENOS d.o.o. ]]></institution_hr><institution_en><![CDATA[GENOS Ltd ]]></institution_en><team_members_id>871079, </team_members_id><team_members_names><![CDATA[Nikol Mraz, ]]></team_members_names><keywords_hr><![CDATA[Neuroznanost, Glikozilacija, Glikoproteomika, Spektrometrija mase, Post-translacijska Modifikacija, Glikani]]></keywords_hr><keywords_en><![CDATA[Neuroscience, Glycosylation, Glycoproteomics, Mass Spectrometry, Post-translational Modification, Glycans]]></keywords_en><summary_hr><![CDATA[Posttranslacijska modifikacija proteina je važan mehanizam kojim se regulira njihova funkcija i aktivnost. Jedna takva modifikacija je glikozilacija, proces kojim se složene molekule šećera zvane glikani vežu za okosnicu proteina, tvoreći tako hibridnu molekulu poznatu kao glikoprotein koja se sastoji od proteinskog dijela i ugljikohidratnog dijela. Poznato je da glikoproteini imaju važne funkcije u središnjem živčanom sustavu i da su uključeni u brojne temeljne neurobiološke procese, uključujući adheziju živčanih stanica, izrastanje neurita, navigaciju aksona, formiranje sinapsi te sinaptičku plastičnost. Međutim, trenutno se vrlo malo zna o tome kako glikanski dijelovi reguliraju funkciju moždanih glikoproteina ili čak koje su glikanske strukture vezane za određene glikoproteine. U ovom projektu kanimo poduzeti prve korake prema rješavanju ove crne rupe u znanju izvođenjem ciljanog glikoproteomskog istraživanja ljudskog mozga. Predloženi projekt nadovezuje se na naš prethodni utjecajni rad u kojem smo proveli opsežnu multiregionalnu komparativnu studiju glikoma možga i identificirali nekoliko istaknutih glikana od interesa. Zbog njihovih karakterističnih obrazaca ekspresije, pretpostavljamo da bi ti glikani mogli biti povezani s specifičnim funkcijama određenih regija mozga, neurorazvojnim procesima ili ponašanjima i kognitivnim funkcijama koje su jedinstveno ljudske. Međutim, trenutno nije poznato koje glikoproteine ti glikani modificiraju. Kombinacijom selektivnog obogaćivanja glikoproteina koji nose određene tipove glikana sa dubinskom analizom ciljanih glikoproteina na razini glikozilacijskih mjesta korištenjem najsuvremenije analize masene spektrometrije, naš je cilj identificirati i karakterizirati glikoproteine koji su modificirani ovim posebnim glikanima od interesa. Ovo će utrti put za buduće funkcionalne glikomske studije u kojima možemo manipulirati tim glikoproteinima i njihovim glikanskim modifikacijama kako bismo istražili njihove biološke funkcije.]]></summary_hr><summary_en><![CDATA[Post-translational modification of proteins in an important mechanism by which the function and activity of the modified proteins is regulated. One such modification is glycosylation, the process by which complex sugar molecules called glycans are attached to the protein backbone, thus forming a hybrid molecule known as a glycoprotein which is composed of a protein part and a carbohydrate part. Glycoproteins are known to have important functions in the central nervous system are involved in numerous fundamental neurobiological process, including  neural cell adhesion, neurite outgrowth, axon targeting, synapse formation and synaptic plasticity. However, currently very little is known about how the glycan part regulates the function of brain glycoproteins or even which glycan structures are attached to particular glycoproteins. In this project, we aim to take the first steps towards addressing this knowledge gap by performing a targeted glycoproteomic exploration of the human brain. The proposed project builds on our previous ground-breaking work in which we performed a large-scale multi-regional comparative brain glycomics study and identified several salient glycan features. Due to their distinctive expression patterns, we hypothesise that these glycans of interest are associated with region-specific brain functions, neurodevelopmental processes, or behaviours or cognitive functions that are uniquely human. However, at present, it is not known which glycoproteins they modify. Through a combination of selective enrichment of glycoproteins that bear particular glycan types and in-depth site-specific glycoproteomics analysis using cutting-edge mass spectrometry analysis, our objective is to identify and characterise the glycoproteins that are modified with these glycans of interest. This will pave the way for future functional glycomics studies in which we can manipulate these glycoproteins and their glycan modifications to investigate their biological functions.]]></summary_en></project><project>
<id>18728</id><title_hr><![CDATA[Dekodiranje interakcije između patogenih i korisnih mikroorganizama vinove loze koristeći multi-omics pristup: od transkriptoma do metaboloma]]></title_hr><title_en><![CDATA[Decoding interplay between grapevine pathogenic and beneficial microorganisms using multi-omics approach: from transcriptome to metabolome]]></title_en><user_id>3236</user_id><user_firstLast_name>Katarina Hančević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-8832</code><acronim><![CDATA[INTER-OMICS]]></acronim><duration>31.12.2025 - 30.12.2028</duration><status>U tijeku</status><financ_value>198.700,00 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, Interdisciplinarne biotehničke znanosti, </scie_field_hr><scie_field_en>Agriculture, Interdisciplinary biotechnical sciences, </scie_field_en><institution_hr><![CDATA[Institut za jadranske kulture i melioraciju krša]]></institution_hr><institution_en><![CDATA[Institute for Adriatic Crops and Karst Reclamation in Split]]></institution_en><team_members_id>2826, 26106, 865019, 22737, 868487, 29198, 29121, 870960, 870962, </team_members_id><team_members_names><![CDATA[Tomislav Radić, Mate Čarija, Emanuel Gaši, Silvija Černi, Luca Nerva, Giorgio Gambino, Raffaella Balestrini, Julie CHONG, Mary-Lorene GODDARD, ]]></team_members_names><keywords_hr><![CDATA[vinova loza, RNA-sekvenciranje, GLRaV-3, AMF, metabolom]]></keywords_hr><keywords_en><![CDATA[grapevine, RNA-sequencing, GLRaV-3, AMF, metabolome]]></keywords_en><summary_hr><![CDATA[Vinova loza je jedna od najvažnijih kultura koje se uzgajaju diljem svijeta te je s vremenom postala ključna modelna biljka za proučavanje višestrukih interakcija kod višegodišnjih drvenastih vrsta. Patogeni virusi predstavljaju ozbiljan biotički stres za lozu zbog mnogih poremećaja koji mogu rezultirati smanjenim urodom, kvalitetom ploda i skraćenim životnim vijekom loze. S druge strane, korisni mikroorganizmi na korijenu kao što su arbuskularne mikorizne gljive (AMF) imaju potencijal ublažiti stres biotičkog i abiotičkog podrijetla. Pozadina bioloških promjena u vinovoj lozi, u svjetlu tripartitne interakcije je nedovoljno istražena unatoč tome što je sveprisutna u agroekosustavima diljem svijeta.Kako bi se pružio novi uvid u složene interakcije između virusa vinove loze i AMF-a, glavni cilj projekta INTER-OMICS je istražiti osnovne promjene u profilima transkriptoma pristupom visokoprotočnog RNA-sekvenciranja. Različito eksprimirani geni (DEG) u vinovoj lozi bit će identificirani i povezani s agronomskim svojstvima vinove loze. Također će se proučiti promjene u profilu transkriptoma AMF- a. Analize metaboloma vinove loze otkrit će da li se i u kolikoj mjeri DEG promjene odražavaju na metabolom vinove loze. Ispitivanjem DEG-a i metaboloma u lišću i korijenu omogućit će se bolje razumijevanje procesa međudjelovanja virusa vinove loze i AMF-a u nadzemnim i podzemnim biljnim organima te njihova sinteza i značenje za ponašanje biljke u cjelini. Projekt ima za cilj produbiti razumijevanje molekularnih mehanizama te otkriti neke nepoznate aspekte interakcija vinove loze, virusa i AMF-a. Dobiveni rezultati mogli bi predstavljati osnovu za razvoj strategija temeljenih na prirodnim metabolitima u poljoprivrednoj praksi za povećanje otpornosti vinove loze ili ublažavanje virusnih oštećenja.]]></summary_hr><summary_en><![CDATA[Grapevine is one of the most important crops grown worldwide and has become essential model plant for studying multiple interactions in perennial woody species. Pathogenic viruses represent serious biotic stress to a grapevine for many disturbances which could result in reduced yield, grape quality and shortened lifespan. On the other hand, root-beneficial microorganisms such as arbuscular mycorrhizal fungi (AMF) have a potential to alleviate the stress of biotic and abiotic origin. The background of biological processes in the grapevine, in the light of tripartite interaction is completely under-investigated despite being predominantly present in agroecosystems worldwide. To provide novel insight in complex interactions between grapevine virus and AMF, the main goal of INTER-OMICS is to investigate core changes in transcriptome profiles by high-throughput RNA-sequencing approach. The differentially expressed genes (DEGs) in grapevine will be identified and associated with agronomic grapevine performances. Changes in AMF transcriptome profile will also be studied. Grapevine metabolome profiling will reveal whether and to what extent DEG changes are reflected in the grapevine metabolome. By examining DEGs and metabolome in leaves and roots, better understanding of processes of grapevine-virus-AMF interactions in upper- and under-ground plant organs and their synthesis into overall plant behaviour will be reached. INTER-OMICS aims to deepen the understanding of molecular mechanisms beyond manifested changes and reveal some unknown aspects of grapevine-virus-AMF interactions. Gained results could present pioneer base for development of natural metabolite-based strategies in agricultural practice for enhancing grapevine resistance or mitigating viral damage.]]></summary_en></project><project>
<id>18732</id><title_hr><![CDATA[Sunčeva kromosfera kroz oči ALMA-e: nova interferometrija visokog razlučivanja i MHD modeli za proučavanje skrivenih valnih dinamika]]></title_hr><title_en><![CDATA[Solar Chromosphere in ALMA&#39;s Eyes: Newly Ascending High-Resolution Interferometry and MHD Modeling to Reveal Hidden Wave Dynamics]]></title_en><user_id>6078</user_id><user_firstLast_name>Roman Brajša</user_firstLast_name><svouser_id>870675</svouser_id><svouser_firstLast_name>Miroslav Barta</svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-3228</code><acronim><![CDATA[SCi-AEneAs]]></acronim><duration>22.12.2025 - 21.12.2028</duration><status>U tijeku</status><financ_value>160.200,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Geodetski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Geodesy]]></institution_en><team_members_id>6028, 865039, </team_members_id><team_members_names><![CDATA[Davor Sudar, Filip Matković, ]]></team_members_names><keywords_hr><![CDATA[fizika Sunca, helioseizmologija, kromosfera, MHD valovi, radiozračenje]]></keywords_hr><keywords_en><![CDATA[solar physics, helioseismology, chromosphere, MHD waves, radio radiation]]></keywords_en><summary_hr><![CDATA[Energetska povezanost kroz Sunčevu atmosferu u obliku valnog toka predstavlja danas vrlo aktualnu temu istraživanja. Ona se bavi još uvijek neriješenim problemom zagrijavanja gornjih atmosferskih slojeva. Štoviše, detaljna analiza promatranih valnih dinamika u kombinaciji s numeričkim modeliranjem, koje povezuje karakteristike širenja valova s fizikalnim parametrima struktura u Sunčevoj atmosferi koje služe kao njihovi valovodi, pruža moćnu dijagnostičku metodu, poznatu kao kromosferska/koronalna seizmologija. Ključ za hvatanje putujućih valnih poremećaja poput valnih vlakova ili razvijajućih udarnih valova leži u promatranjima visoke kadence i visokog razlučivanja. To je ključno jer modeli ukazuju na važnost fino strukturiranih i visoko dinamičnih obilježja, bližih skali disipacije. Vrlo nedavni razvoj donosi veliku priliku u tom pogledu s novim podacima o Suncu dobivenim iz ALMA-e: neviđena kadenca od 0.192 s, razlučivost od ~0.2&#39;&#39;, te izravna povezanost između opaženog intenziteta i odstupanja temperature Sunčeve plazme čine ova opažanja zaista jedinstvenim dijagnostičkim materijalom za postizanje istraživačkog cilja. Kako ova novo razvijena metoda za solarnu ALMA interferometriju pruža svojevrsni &#39;mikroskop&#39;, širi kontekst mora biti osiguran putem optičkih, UV/EUV i cm/dm radio podataka. Interpretacija i razumijevanje podataka bit će ostvareni uz pomoć numeričkog MHD modeliranja. Krajnji cilj je razumijevanje prijenosa valne energije kroz atmosferske slojeve i otkrivanje 3D fine strukture (&#39;valovoda&#39;) Sunčeve atmosfere koja se proučava. Predloženi projekt okuplja snažan međunarodni tim koji posjeduje duboko ALMA-insajdersko znanje (vodeći znanstvenici dvaju međunarodnih ALMA razvojnih studija su voditelj i suvoditelj), ima dugogodišnje iskustvo u analizi valnih i oscilatornih obilježja u Sunčevoj atmosferi te proširuje stručnost u numeričkom modeliranju primijenjenom u kromosferskoj seizmologiji.]]></summary_hr><summary_en><![CDATA[Energetic coupling across the solar atmosphere in form of the wave-flux represents hot research topic nowadays. It addresses namely the still unresolved problem of heating of the upper atmospheric layers. Moreover, detailed analysis of the observed wave dynamics in conjunction with numerical modeling, which links wave-propagation characteristics with physical parameters of the structures in the solar atmosphere that serve as their wave-guides, provides a powerful diagnostic method, commonly known as chromospheric/coronal seismology. The key for capturing traveling wave disturbances like wave-trains or developing shocks lays in high-cadence and high-resolution observations. It is essential, as the models indicate importance of fine-structured and highly-dynamic features, closer to the dissipation scale. Very recent development brings a great opportunity in this respect with new solar data from ALMA: Unprecedented cadence of 0.192 s, resolution of ~0.2”, and the direct linkage between observed intensity and the temperature-deviations of the solar plasma make the observations really unique diagnostic material for accomplishing the research goal. As this newly developed method for solar ALMA interferometry provides a ‘microscope’, the broader context has to be supplied by means of the optical, UV/EUV, and cm/dm radio data. Interpretation and understanding the data will be achieved with help of numerical MHD modeling. The ultimate goal is understanding the wave-energy transport across the atmospheric layers and revealing the 3D fine structure (the ‘wave-guides’) of the solar atmosphere under study. Proposed project brings together a strong international team, which holds deep ALMA-insider know-how (leading scientists of two international ALMA Development Studies are the PI and Co-PI), has long-term experience in analysis of wave and oscillatory features in the solar atmosphere, and extends by expertise in numerical modeling applied in chromospheric seismology.]]></summary_en></project><project>
<id>18734</id><title_hr><![CDATA[Biljna ulja u hranidbi koza za dobivanje mlijeka s funkcionalnim sastojcima]]></title_hr><title_en><![CDATA[Plant oils in goat nutrition with the aim to produce milk with functional ingredients]]></title_en><user_id>3594</user_id><user_firstLast_name>Željka Klir Šalavardić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2025-02</proposal_call><code>UIP-2025-02-9518</code><acronim><![CDATA[GoFunctional]]></acronim><duration>19.02.2026 - 18.02.2031</duration><status>U tijeku</status><financ_value>297.800,00 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, Prehrambena tehnologija, Interdisciplinarne biotehničke znanosti, </scie_field_hr><scie_field_en>Agriculture, Food technology, Interdisciplinary biotechnical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Fakultet agrobiotehničkih znanosti Osijek]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Agrobiotechnical Sciences in Osijek]]></institution_en><team_members_id>29487, 20506, 870489, </team_members_id><team_members_names><![CDATA[Mario Ronta, Đurđica Kovačić, Lidija Šoher, ]]></team_members_names><keywords_hr><![CDATA[biljna ulja, hranidba, koze, mlijeko, funkcionalni sastojci]]></keywords_hr><keywords_en><![CDATA[plant oils, nutrition, goats, milk, functional ingredients]]></keywords_en><summary_hr><![CDATA[S obzirom na pozitivne učinke kozjeg mlijeka na zdravlje ljudi, posljednjih je dvadeset godina aktualno modeliranje obroka koza u cilju povećanja funkcionalnih sastojaka u mlijeku. Biljna ulja kao dodatak u obrocima za koze izvor su blagotvornih sastojaka, kao što su masne kiseline, vitamini, minerali i polifenoli, koji imaju povoljan utjecaj na zdravlje potrošača. Poznato je kako je uzgoj koza u odnosu na ostale domaće životinje najviše u skladu s ekološkim principima što svakako doprinosi proizvodnji zdrave hrane. Pored toga, biljna ulja u hradnibi koza mogu doprinijeti i dodanom vrijednošću proizvedenog kozjeg mlijeka, odnosno povećanju funkcionalnih sastojaka. Stoga, cilj ovoga projektnog prijedloga je implementirati različita biljna ulja (ulje bundeve, konoplje i podlanka) u obroke koza i jaradi uz praćenje proizvodnih pokazatelja, pokazatelja in vitro fermentacije krmiva u sadržaju buraga te pokazatelja zdravstvenog statusa. Također, cilj je i utvrditi kvalitetu kozjeg mlijeka s naglaskom na analizu funkcionalnih sastojaka. Istraživanja će se temeljiti na dodavanju biljnih ulja u krmne smjese za koze i jarad tijekom tri istraživanja. U prvom istraživanju će u smjese biti dodano ulje bundeve, u drugom istraživanju ulje konoplje te u trećem istraživanju ulje podlanka, počevši od druge godine projekta. U drugoj, trećoj i četvrtoj godini, tijekom provedbe pokusa na farmi, uzet će se uzorci krvi koza i jaradi (antioksidativni status, metabolički profil: hematologija, biokemija i aktivnost enzima) te uzorci mlijeka (antioksidativni status, kemijska analiza mlijeka i funkcionalnih sastojaka: masne kiseline, polifenoli, vitamini i minerali). Utvrdit će se i proizvodni pokazatelji koza i jaradi u porastu tijekom svakog uzorkovanja. Nakon provedenih istraživanja očekuje se povećanje funkcionalnih sastojaka u kozjem mlijeku što će rezultirati dodanom vrijednošću mlijeka od koje bi imali koristi uzgajivači koza te konzumenti kozjeg mlijeka.]]></summary_hr><summary_en><![CDATA[Given the positive effect of goat milk on human health, modeling goat diets to increase functional ingredients in milk has been a topic for the past twenty years. Plant oils as an addition to goat diets are a source of beneficial ingredients, such as fatty acids, vitamins, minerals and polyphenols, which have a positive effect on consumer´s health. It is known that goat farming is the most environmentally friendly compared to other livestock, which certainly contributes to the production of healthy food. In addition, vegetable oils in goat feed may contribute to the added value of goat milk, i.e. increased content of functional ingredients. Therefore, the aim of this project proposal is to implement certain plant oils (pumpkin, hemp and safflower oil) in goats and goat kids diets while monitoring production traits, indicators of in vitro fermentation of feed in the rumen fluid and indicators of health status. The aim is also to determine the quality of goat milk with an emphasis on the analysis of functional ingredients. The research will be based on the addition of plant oils to feed mixtures for goats and goat kids during three studies. In the first study, pumpkin oil will be added to the mixtures, in the second study hemp oil and in the third study camelina oil, starting from the second year of the project. In the second, third and fourth year, during the implementation of the on-farm trial, blood samples of goats and goat kids will be taken (antioxidant status, metabolic profile: hematology, biochemistry and enzyme activity) and milk samples (antioxidant status, chemical analysis of milk and functional ingredients: fatty acids, polyphenols, vitamins and minerals). Production traits of goats and growing goat kids will be determined during each sampling. At the end of the research, it is expected that the functional ingredients in goat milk will increase, which will result in value-added product that would be beneficial to goat farmers and goat milk consumers.]]></summary_en></project><project>
<id>18736</id><title_hr><![CDATA[Međustanična komunikacija u dijabetičkoj bolesti bubrega]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4348</user_id><user_firstLast_name>Natalija Filipović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-5516</code><acronim><![CDATA[RENEX]]></acronim><duration>01.12.2025 - 01.12.2031</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Split School of Medicine]]></institution_en><team_members_id>872892</team_members_id><team_members_names><![CDATA[ Doktorand: Karla Svaguša ]]></team_members_names><keywords_hr><![CDATA[Dijabetička bolest bubrega, koneksini, paneksini, tijesni spojevi, endotel, podociti, epitel tubula]]></keywords_hr><keywords_en><![CDATA[Diabetic kidney disease, connexins, pannexins, gap-junctions, endothelium, podocytes, tubular epithelium]]></keywords_en><summary_hr><![CDATA[Dijabetička bolest bubrega (DBB) je jedna od najozbiljnijih mikrovaskularnih komplikacija šećerne bolesti, koja postaje vodeći uzrok završnog stadija kronične bubrežne bolesti širom svijeta. Unatoč opsežnim studijama, patofiziološki mehanizmi DBB nisu još u potpunosti razjašnjeni, a postojeći terapijski pristupi nisu učinkoviti u svim slučajevima i/ili je njihova primjena povezana s ozbiljnim nuspojavama. Sve veći broj recentnih studija ukazuje na ulogu izravne međustanične komunikacije i parakrine ATP signalizacije u patofiziologiji DBB, pri čemu glavnu ulogu imaju kanali formirani od koneksina i paneksina. Blokatori koneksinskih i paneksinskih kanala sve se više istražuju kao učinkovita terapijska strategija za inhibiciju sterilne upale u različitim patološkim stanjima, a mogli bi se pokazati uspješnom strategijom za prevenciju ili liječenje DBB. Međutim, uloga koneksinskih i paneksinskih kanala u specifičnim populacijama stanica bubrega još je daleko od potpunog razumijevanja. Cilj je predloženih istraživanja rasvijetliti detaljno ulogu koneksina i paneksina u međustaničnoj komunikaciji različitih tipova stanica tijekom razvoja DBB. Ove ciljeve planiramo ostvariti kombiniranjem više istraživačkih pristupa: detaljnom analizom izražaja koneksina/paneksina u uzorcima tkiva pacijenata oboljelih od šećerne bolesti,   analizom transkriptoma pojedinih populacija stanica bubrega (podociti, epitelne stanice tubula, endotelne stanice) miševa s farmakološki izazvanom šećernom bolešću  te korištenjem animalnih modela miševa kojima je selektivno isključen izražaj koneksina/paneksina u određenim staničnim populacijama bubrega. Rezultati ovih istraživanja pružit će nam bolje razumijevanje uloge koneksina/paneksina u patogenezi DBB, a njihovo poznavanje osnovni je preduvjet za svrsishodnu i efikasnu upotrebu modulacije koneksinskih i paneksinskih kanala kao terapijskog cilja u prevenciji i liječenju DBB, kao i procjenu mogućih štetnih učinaka (primjerice nefrotoksičnosti). ]]></summary_hr><summary_en><![CDATA[Diabetic kidney disease (DKD) is one of the most serious microvascular complications of diabetes, becoming the most common cause of end-stage renal disease worldwide. Despite extensive studies, the pathophysiological mechanisms of DKD are not fully understood, and existing therapeutic approaches are not effective in all cases and/or their use is associated with severe side effects. A growing number of recent studies point to the role of direct intercellular communication and paracrine ATP signaling in the pathophysiology of DKD, with channels formed by connexins and pannexins playing the main role. Blockers of connexin and pannexin channels are increasingly being investigated as an effective therapeutic strategy to inhibit sterile inflammation in various pathological conditions and may prove to be a successful strategy to prevent or treat DKD. However, the role of connexin and pannexin channels in specific renal cell populations is far from fully understood. The aim of this research project is to elucidate in detail the role of connexins and pannexins in the intercellular communication of different cell types during DKD development. We plan to achieve these goals by combining several research approaches: detailed analysis of connexin/pannexin expression in tissue samples from patients with diabetes, transcriptome analysis of individual kidney cell populations (podocytes, tubule epithelial cells, endothelial cells) from mice with pharmacologically induced diabetes, and the use of animal models in which connexin/pannexin expression is selectively silenced in specific kidney cell populations. The results of these studies will provide us with a better understanding of the role of connexin/pannexin in the pathogenesis of DKD, as a prerequisite for the targeted and efficient use of modulation of connexin and pannexin channels as a therapeutic target in the prevention and treatment of DKD, as well as for the evaluation of potential adverse effects (eg, nephrotoxicity).]]></summary_en></project><project>
<id>18739</id><title_hr><![CDATA[Prijenos signala ljudskim tijelom za nosive i implantabilne sustave]]></title_hr><title_en><![CDATA[]]></title_en><user_id>21443</user_id><user_firstLast_name>Željka Lučev Vasić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-5173</code><acronim><![CDATA[IBIS]]></acronim><duration>01.12.2025 - 30.11.2031</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>872982</team_members_id><team_members_names><![CDATA[ Doktorand: Luka Klaić ]]></team_members_names><keywords_hr><![CDATA[Prijenos signala ljudskim tijelom, mjerenje prijenosne karakteristike, elektromagnetski modeli, elektronička sučelja, ugradbeni računalni sustavi]]></keywords_hr><keywords_en><![CDATA[Intrabody communication, transfer characteristic measurement, electromagnetic models, electronic interfaces, embedded systems]]></keywords_en><summary_hr><![CDATA[U komunikaciji putem ljudskog tijela (eng. intrabody communication, IBC) čovjek postaje dio prijenosnog puta signala između odašiljača i prijamnika smještenih na površini kože, u njezinoj blizini ili implantiranih unutar korisnikovog tijela. IBC sustavi koriste niže frekvencijsko područje od standardnih bežičnih sustava te imaju nižu potrošnju energije i niži domet. IBC kanal se mijenja dinamički s promjenom konfiguracije i položaja elektroda, ispitanikom i njegovim kretnjama te okolinom. Potencijalne primjene IBC-a su vrlo široke: od biotelemetrije i medicine do komunikacije između različitih elektroničkih uređaja i sigurnosnih sustava.U ovom projektnom prijedlogu planiramo istražiti mehanizme prijenosa IBC kanala za nosive i implantabilne sustave u širokom frekvencijskom području. Ključni ciljevi uključuju mjerenja prijenosnih karakteristika i utjecajnih parametara IBC kanala, modeliranje mehanizama prijenosa signala ljudskim tijelom, kao i projektiranje i izvedbu senzorskih sučelja i ugradbenih računalnih sustava niske potrošnje. Radi ostvarivanja ciljeva projekta naša istraživačka grupa planira implementirati novi pristup modeliranju, kombinirajući mjerenja i modeliranja svih utjecajnih parametara u IBC kanalima. Novorazvijena IBC sučelja, sa standardnim ili tekstilnim elektrodama, će se koristiti za karakterizaciju odgovarajućih komunikacijskih kanala prema predloženoj eksperimentalnoj metodologiji. Ispitivanja će se provesti na raznolikoj skupini sudionika, na fantomima ljudskog tijela (tekući, gel i životinjski modeli) i svinjskom mesu u nekoliko specifičnih okolina. Na temelju dobivenih rezultata će se dati generalne smjernice za izvedbu IBC uređaja, koje će se verificirati tijekom razvoja vlastitih prototipova IBC uređaja i senzorskih sučelja, namijenjenih za dvije primjene prijenosa signala ljudskim tijelom s oprečnim zahtjevima – jedna sa zahtjevom na nisku potrošnju (kemijski senzori, mjerenje bioimpedancije), a druga na visoku brzinu prijenosa podataka.]]></summary_hr><summary_en><![CDATA[In an intrabody communication (IBC) system the human body is used as a part of a communication channel between the transmitters and receivers placed on or near the skin, or implanted within the user’s body. IBC systems use lower frequency band than standard wireless systems, and they have lower power consumption and lower range. IBC channel changes dynamically with electrode configuration and positions, subject, subject’s movements, and surrounding environment. Possible applications of IBC are very broad: from biotelemetry and medicine to the communication between various electronic devices and security systems.This proposal seeks to investigate the transmission mechanisms of the IBC channel for both wearable and implantable systems in a broad frequency range. Key objectives include characterizing IBC channel transmission characteristics and influential parameters, developing simulation models for intrabody communication, and designing sensor interfaces and low-power embedded systems. To achieve these objectives, our research group plans to implement novel modelling approaches, combining measurements and modelling of all influential parameters in IBC channels. We will utilize novel IBC interfaces, featuring standard or textile electrodes, to characterise respective IBC transmission channels based on the proposed experimental methodology. Experiments will be conducted on a diverse group of individuals, on human body phantoms (liquid, gel, and animal models) in several specific environments. Combining obtained results, general guidelines for IBC devices design will be given and verified during the development of proprietary prototypes of IBC devices and sensor interfaces for two groups of IBC applications with opposing requirements – one requiring low power consumption (chemical sensing, bioimpedance monitoring), and the other requiring high data rate communication.]]></summary_en></project><project>
<id>18742</id><title_hr><![CDATA[VET participation, retention, and educational policies in the wake of COVID 19 - A cross-country exploration (VETprep)]]></title_hr><title_en><![CDATA[]]></title_en><user_id>21221</user_id><user_firstLast_name>Josip Šabić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-1081</code><acronim><![CDATA[]]></acronim><duration>01.12.2025 - 30.11.2030</duration><status>U tijeku</status><financ_value>60,00 eur</financ_value><scie_area_hr>Interdisciplinarno područje znanosti</scie_area_hr><scie_area_en>Interdisciplinary scientific area</scie_area_en><scie_field_hr>Obrazovne znanosti, </scie_field_hr><scie_field_en>Educational Sciences, </scie_field_en><institution_hr><![CDATA[Institut za društvena istraživanja]]></institution_hr><institution_en><![CDATA[Institute for Social Research in Zagreb]]></institution_en><team_members_id>872953</team_members_id><team_members_names><![CDATA[ Doktorand: Jurja Jakob ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>18746</id><title_hr><![CDATA[Fiskalna decentralizacija u Hrvatskoj – trenutno stanje, izazovi i moguća rješenja]]></title_hr><title_en><![CDATA[Fiscal decentralization in Croatia – current state, challenges, and potential solutions ]]></title_en><user_id>21290</user_id><user_firstLast_name>Branko Stanić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2025-02</proposal_call><code>UIP-2025-02-3913</code><acronim><![CDATA[FISDEC]]></acronim><duration>15.12.2025 - 14.12.2030</duration><status>U tijeku</status><financ_value>156.469,44 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, Interdisciplinarne društvene znanosti, </scie_field_hr><scie_field_en>Economy, Interdisciplinary social sciences, </scie_field_en><institution_hr><![CDATA[Institut za javne financije]]></institution_hr><institution_en><![CDATA[Institute of Public Finance]]></institution_en><team_members_id>24030, 871072, 25362, </team_members_id><team_members_names><![CDATA[Josip Franić, Ana María Ríos Martínez, Simona Prijaković, ]]></team_members_names><keywords_hr><![CDATA[fiskalna decentralizacija, lokalne financije, fiskalna autonomija, regionalne nejednakosti, fiskalni transferi, ekonomski razvoj, prostorna analiza]]></keywords_hr><keywords_en><![CDATA[fiscal decentralization, local finances, fiscal autonomy, regional inequalities, fiscal transfers, economic development, spatial analysis]]></keywords_en><summary_hr><![CDATA[Projekt Fiskalna decentralizacija u Hrvatskoj – trenutno stanje, izazovi i moguća rješenja (FISDEC) istražuje kako fiskalna decentralizacija (FD) utječe na lokalne vlasti u Hrvatskoj kroz pet ključnih istraživačkih cjelina. Cilj je analizirati: i) fiskalni okvir lokalnih jedinica, ii) utjecaj fiskalne autonomije na lokalni ekonomski razvoj, iii) ulogu fiskalnih transfera u osiguravanju efikasnosti pružanja javnih usluga, iv) povezanost FD s dohodovnom nejednakošću te v) prostornu dinamiku FD i lokalne zaduženosti. Istraživanje se temelji na naprednim kvantitativnim metodama, uključujući dinamičke ekonometrijske modele te GIS analizu za prostorno mapiranje fiskalnih pokazatelja i identificiranje regionalnih obrazaca. Korištenjem prostorne ekonometrije istražit će se učinci fiskalne autonomije i transfera na ekonomski razvoj, zaduženost i javne usluge, dok će se analiza FD, s naglaskom na fiskalnu autonomiju i sustav izravnjanja, usmjerit na ublažavanje regionalnih nejednakosti. Očekivani rezultati uključuju razvoj pokazatelja za mjerenje FD, znanstvene publikacije, otvorenu bazu podataka, te preporuke za politike usmjerene na poboljšanje fiskalne održivosti i regionalnog razvoja. Projekt će doprinijeti oblikovanju učinkovitijeg i pravednijeg sustava lokalnog financiranja te jačanju uloge lokalnih vlasti u gospodarskom rastu.]]></summary_hr><summary_en><![CDATA[The project Fiscal decentralization in Croatia – current state, challenges, and potential solutions (FISDEC) explores the impact of fiscal decentralization (FD) on local governments in Croatia through five key research sections. The aim is to analyze: i) the fiscal framework of local units, ii) the impact of fiscal autonomy on local economic development, iii) the role of fiscal transfers in ensuring the efficiency of public service delivery, iv) the relationship between FD and income inequality, and v) the spatial dynamics of FD and local debt. The research is based on advanced quantitative methods, including dynamic econometric models and GIS analysis for spatial mapping of fiscal indicators and identification of regional patterns. Using spatial econometrics, the study will examine the effects of fiscal autonomy and transfers on economic development, indebtedness, and public services, while the analysis of FD, with a focus on fiscal autonomy and equalization mechanisms, will aim to mitigate regional inequalities. Expected outcomes include the development of indicators for measuring FD, scientific publications, an open-access database, and policy recommendations aimed at improving fiscal sustainability and regional development. The project will contribute to the creation of a more efficient and equitable local financing system and strengthen the role of local governments in economic growth.]]></summary_en></project><project>
<id>18748</id><title_hr><![CDATA[Električni romobili u urbanim okruženjima: Studija sigurnosti, infrastrukture i dinamike mobilnosti]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1303</user_id><user_firstLast_name>Dario Babić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-4299</code><acronim><![CDATA[eSCURB]]></acronim><duration>12.01.2026 - 11.01.2032</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Tehnologija prometa i transport, </scie_field_hr><scie_field_en>Transport technology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet prometnih znanosti]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Transport and Traffic Sciences]]></institution_en><team_members_id>873043</team_members_id><team_members_names><![CDATA[ Doktorand: Shirin Rizehbandi ]]></team_members_names><keywords_hr><![CDATA[električni romobili, urbani sustavi, održiva mobilnost, mikromobilnost, prometna sigurnost, ponašanje u mobilnosti]]></keywords_hr><keywords_en><![CDATA[electric scooters, urban systems, sustainable mobility, micromobility, traffic safety, mobility behaviour]]></keywords_en><summary_hr><![CDATA[Electricni romobili su važna i sve popularnija tehnologija u urbanim područjima kao sredstvo privatne pa čak i dijeljene mobilnosti. U tom smislu, uvođenje e-romobila u urbano kretanje predstavlja jedno rješenje za balansiranje održive mobilnosti i potreba mobilnih korisnika. Međutim, urbanu mobilnost donekle ograničava velik broj i razvijene gradove s cestovnom infrastrukturom koja je razvijana za potrebe prometa i transporta proteklih desetljeća i stoljeća. Budući da trenutno ne postoji urbana infrastruktura namijenjena isključivo za e-romobile i s brzorastućom uporabom takvog načina prijevoza, postoje zabrinutosti vezane uz sigurnost i dugoročnu funkcionalnost urbanih prometnih sustava, posebice kada postoji mogućnost višestrukih sukoba e-romobila s drugim sudionicima u urbanom prometnom sustavu. Međutim, ako se njihova uporaba želi poticati i pretvoriti u široku uporabu, potrebno je što prije provesti temeljitu analizu svih aspekata njihove uporabe kako bi se prekinuo ciklus neuređene ili nedovoljno regulirane uporabe i kako bi se mogli integrirati u urbanu mobilnost. Glavni cilj je razabrati na koji način električni romobili i njihovi korisnici trenutno sudjeluju u mobilnosti u urbanom kontekstu, kako to utječe na njihovu sigurnost i opću sigurnost svih sudionika u mobilnosti te kako prometna sigurnost utječe na pojavu sve veće uporabe električnih romobila u urbanim kontekstima. Projekt je interdisciplinaran jer će se infrastrukturna, ponašajna, psihološka, sigurnosna i logistička pitanja analizirati i rješavati s nizom kvantitativnih i kvalitativnih metoda. Konačni cilj je razviti duboko razumijevanje na koji način su električni romobili uključeni u tradicionalnu mješavinu mobilnosti i razviti smjernice o tome kako ih sigurno i održivo uključiti kako bi se maksimalno iskoristile njihove potencijalne prednosti za osobnu mobilnost u urbanom kontekstu.]]></summary_hr><summary_en><![CDATA[Electric scooters are an important and emerging technology in urban areas that are increasingly popular as a means of private and even shared mobility. In that regard, introducing e-scooters into urban mobility presents one solution for balancing sustainable mobility and the needs of mobile users. However, urban mobility is limited to some extent in large and developed cities with road infrastructure that has been developed for traffic and transportation needs over the last decades and centuries. With no current urban infrastructure designed exclusively for e­scooters and with the fast-growing use of that type of transportation mode, there are concerns related to the safety and long-term functionality of urban transport systems, especially when there is a possibility of multiple conflicts of e­scooters with other participants in the urban mobility system, However, if they are to be encouraged and transformed into widespread use, an In-depth analysis of all aspects of their use needs to be performed as soon as possible so that the cycle of unregulated or under-regulated use is broken and they can be integrated into urban mobility, The main aim is to discern how electric scooters and their users currently take part in the mobility sphere in an urban context, how this influences their safety and the general safety of all mobility participants, and how traffic safety is impacted by the emergence of increasing electric scooter use in urban contexts. The project is interdisciplinary since infrastructural, behavioral, psychological, safety, and logistical issues will be analyzed and addressed with a multitude of quantitative and qualitative methods. The final goal is to develop an in-depth understanding of how electric scooters are included in the traditional mobility mix and to develop guidelines on how to incorporate them in a safe, sustainable way to maximally use their potential benefits for personal mobility in an urban context.]]></summary_en></project><project>
<id>18749</id><title_hr><![CDATA[Oksidacija lipida u staničnim membranama vlakanastih stanica leće oka kao mogući čimbenik u razvoju mrene]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6123</user_id><user_firstLast_name>Marija Raguž</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-9068</code><acronim><![CDATA[LipidOx]]></acronim><duration>01.12.2025 - 01.12.2031</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Split School of Medicine]]></institution_en><team_members_id>872942</team_members_id><team_members_names><![CDATA[ Doktorand: Mateo Šerić ]]></team_members_names><keywords_hr><![CDATA[Oksidacija lipida, stanična membrana, vlaknaste stanice leće oka, mrena, kolestrol, kolesterolova domena]]></keywords_hr><keywords_en><![CDATA[Lipid oxidation, plasma membranes, eye lens fiber cells, cataracts, cholesterol, cholesterol bilayer domain]]></keywords_en><summary_hr><![CDATA[Jedan od najčešćih uzroka gubitka vida u svijetu je očna mrena. Kirurški zahvat je trenutno jedino učinkovito liječenje. Povećanje koncentracije kisika unutar leće i stvaranje reaktivnih spojeva kisika uzroci su nastanka mrene. Razlozi razvoja mrene nisu poznati, ali dokazi upućuju na to da prisutnost visoke razine kolesterola (KO) i domena kolesterolovih dvosloja (DKD) u očnoj leći pomaže pri održavanju prozirnosti i sprječavanju nastanka mrene. DKD također osigurava zasićenost okolnog fosfolipidnog dvosloja kolesterolom. Visoki sadržaj KO u membranama vlaknastih stanica osigurava da fizička svojstva lipidnih membrana ostanu nepromijenjena i neovisna o promjenama u sastavu fosfolipida. Dakle, DKD pomaže u održavanju homeostaze membrane leće, dok se fosfolipidni sastav membrane značajno mijenja s godinama. Naš je cilj razumjeti kako se plazma membrana vlaknastih stanica leće, a posebice lipidni dio dvosloja, mijenja tijekom starenja i stvaranja mrene kako bi se mogle razviti i procijeniti alternativne strategije za prevenciju, usporavanje progresije i izlječenje. Dugoročni cilj je razumjeti ulogu membrane očne leće u održavanju prozirnosti. Membrane leća imaju jedinstven lipidni sastav i strukturu za koje se smatra da održavaju nisku koncentraciju kisika u unutrašnjosti leće. U ovom projektu ćemo (1) prilagoditi i poboljšati metode za pripremu lipidnih modelnih membrana s visokim sadržajem Chol u fiziološkim uvjetima, (2) testirati hipotezu da lipidna peroksidacija može drastično promijeniti organizaciju lipida u modelnim membranama inducirajući stvaranje DKD i KO kristala pri niskom udjelu KO i (3) potvrditi utjecaj peroksidacije lipida na promjene u lateralnoj organizaciji lipida leće i netaknutih staničnih membrana vlaknastih stanica leće oka. Naša istraživanja temeljit će se na korištenju spektroskopskih i mikroskopskih metoda.]]></summary_hr><summary_en><![CDATA[One of the most common causes of vision loss in the world is cataracts. Surgery is currently the only effective treatment. An increase in the oxygen concentration within the lens and the formation of reactive oxygen species are the causes of cataract formation. The reason for the development of cataracts is not known, but evidence suggests that the presence of high levels of cholesterol and cholesterol bilayer domains (CBD) in the eye lens helps to maintain transparency and prevent the formation of cataracts. CBD also ensures that the surrounding phospholipid bilayer is saturated with cholesterol. The saturating cholesterol content in the fiber cell membranes ensures that the physical properties of the lens lipid membranes remain consistent and independent of changes in phospholipid composition. Thus, CBD helps to maintain the homeostasis of lens membranes, while the membrane phospholipid composition changes significantly with age. Our goal is to understand how the fiber cell plasma membrane in the lens, particularly their lipid bilayer portion, change during aging and cataract formation so that alternative strategies for prevention, slowing progression and cure can be developed. The long-term goal is to understand the role of the eye lens membranes in maintaining lens transparency. Lens membranes have unique lipid composition and structure thought to maintain low oxygen concentration inside the lens interior. In this project, we will (1) adapt and improve methods for preparation of lipid model membranes with high Chol content under physiological conditions, (2) test the hypothesis that lipid peroxidation can drastically change organization of lipids in model membranes by inducing the formation of CBDs and Chol crystals at low Chol content, and (3) verify the influence of lipid peroxidation on changes in the lateral organization of lens lipid and intact fiber cell plasma membranes. Our studies will be based on the use of spectroscopic and microscopic methods.]]></summary_en></project><project>
<id>18754</id><title_hr><![CDATA[Interkulturno razumijevanje i stavovi prema različitosti studenata učiteljskih i nastavničkih studija]]></title_hr><title_en><![CDATA[Intercultural Understanding and Attitudes Towards Diversity of Preservice Teacher Education Students]]></title_en><user_id>864835</user_id><user_firstLast_name>Saša Puzić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-1722</code><acronim><![CDATA[INTERDIVE]]></acronim><duration>30.12.2025 - 29.12.2028</duration><status>U tijeku</status><financ_value>128.320,65 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Sociologija, Psihologija, </scie_field_hr><scie_field_en>Sociology, Psychology, </scie_field_en><institution_hr><![CDATA[Institut za društvena istraživanja]]></institution_hr><institution_en><![CDATA[Institute for Social Research in Zagreb]]></institution_en><team_members_id>867932, 26732, 21232, 21221, 12645, 13642, 13808, </team_members_id><team_members_names><![CDATA[Silvia Rogošić, Margareta Gregurović, Iva Odak, Josip Šabić, Jelena Matić Bojić, Karin Doolan, Branislava Baranović, ]]></team_members_names><keywords_hr><![CDATA[interkulturno razumijevanje, interkulturno obrazovanje, stavovi prema različitosti, interkulturna osjetljivost, mješovite metode istraživanja ]]></keywords_hr><keywords_en><![CDATA[intercultural understanding, intercultural education, attitudes towards diversity, intercultural sensitivity, mixed methods research]]></keywords_en><summary_hr><![CDATA[Hrvatska se unutar današnjega europskog prostora suočava s pojačanim dolaskom izbjeglica kao i drugim oblicima suvremenih migracijskih kretanja. Istovremeno, podaci istraživanja pokazuju da su negativni stavovi prema useljavanju stranaca u Hrvatskoj u porastu te da, premda društvo postaje kulturno raznolikije, njegovi građani postaju zatvoreniji za različitosti. Da bi se ovakvi trendovi preokrenuli u smjeru veće tolerancije i prihvaćanja različitosti potrebne su prilagodbe u svim segmentima društva pa tako i u obrazovanju. U području obrazovanja interkulturalizam predstavlja odgovor na izazove koji proizlaze iz suvremene sociokulturne pluralizacije. U tome posebna uloga pripada budućim nastavnicima čije će razumijevanje kulturne različitosti u značajnoj mjeri utjecati na socijalizaciju novih generacija učenika, a time i na širu percepciju raznolikog društvenog konteksta. S obzirom na navedeno, osnovni cilj projekta je ispitati interkulturno razumijevanje i stavove prema različitosti studenata učiteljskih i nastavničkih studija u RH. Takav cilj istraživanja obuhvaća nekoliko istraživačkih pitanja: 1) Da li i u kojoj mjeri studijski programi učiteljskih i nastavničkih studija u Hrvatskoj uključuju sadržaje vezane uz interkulturni pristup obrazovanju? 2) Kako nastavnici na učiteljskim i nastavničkim studijima poimaju sadržaje vezane uz interkulturni pristup obrazovanju? 3) Koje su najvažnije odrednice stavova prema etničkoj različitosti studenata učiteljskih i nastavničkih studija? 4) Koje su najvažnije odrednice interkulturnog razumijevanja i interkulturne osjetljivosti studenata učiteljskih i nastavničkih studija? 5) Kako studenti učiteljskih i nastavničkih studija percipiraju sociokulturne različitosti u suvremenom društvenom kontekstu i smatraju li da je potrebno njihovo tematiziranje u nastavi? U nalaženju odgovora na ova pitanja u istraživanju će se koristiti mješovite metode istraživanja.]]></summary_hr><summary_en><![CDATA[Croatia is facing an increased arrival of refugees as well as other forms of contemporary migration movements. At the same time, research data indicate that negative attitudes toward the immigration of foreigners in Croatia are on the rise and that, although society is becoming more culturally diverse, its citizens are becoming less open to differences. To reverse these trends toward greater tolerance and acceptance of diversity, adaptations are needed in all segments of society, including education. In the field of education, interculturalism serves as a response to the challenges arising from contemporary sociocultural pluralization. Future teachers play a crucial role in this process, as their understanding of cultural diversity will significantly influence the socialization of new generations of students and, consequently, the broader perception of a diverse social context. Given these considerations, the primary aim of the project is to examine intercultural understanding and attitudes toward diversity among preservice teacher education students in Croatia. This research goal encompasses several key research questions: 1) To what extent do preservice teacher education study programs in Croatia include content related to the intercultural approach to education? 2) How do university instructors in preservice teacher education studies perceive content related to the intercultural approach to education? 3) What are the key determinants of attitudes toward ethnic diversity among preservice teacher education students? 4) What are the key determinants of intercultural understanding and intercultural sensitivity among preservice teacher education students? 5) How do preservice teacher education students perceive and experience sociocultural diversity in the contemporary social context and do they believe it should be addressed in teaching? To answer these questions, the study will employ mixed research methods.]]></summary_en></project><project>
<id>18760</id><title_hr><![CDATA[Održiva i optimizirana strategija održavanja trupa trajekata u Jadranskom moru]]></title_hr><title_en><![CDATA[Sustainable and Optimized Hull Maintenance Strategy for  Ferries in the Adriatic Sea]]></title_en><user_id>6793</user_id><user_firstLast_name>Nastia Degiuli</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-4779</code><acronim><![CDATA[SMOOTHS]]></acronim><duration>08.12.2025 - 07.12.2028</duration><status>U tijeku</status><financ_value>199.927,37 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Brodogradnja, Tehnologija prometa i transport, </scie_field_hr><scie_field_en>Naval architecture, Transport technology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>7644, 870915, 870573, 17868, 865419, 870650, 870645, 870604, 865245, </team_members_id><team_members_names><![CDATA[Željko Tuković, Sime Malenica, Ailong Fan, Ivana Martić, Ivan Batistić, Mingyang Zhang, Victor Bolbot, Marko Novaselić, Carlo Giorgio Grlj, ]]></team_members_names><keywords_hr><![CDATA[pomorski promet, trajekt, Jadransko more, obraštanje, strategija održavanja trupa, LCA analiza]]></keywords_hr><keywords_en><![CDATA[maritime transport, ferry, Adriatic Sea, biofouling, hull maintenance strategy, LCA analysis]]></keywords_en><summary_hr><![CDATA[Jadransko more ima stratešku važnost za Republiku Hrvatsku, a njegovo očuvanje ključno je za zaštitu i obnovu njegovih prirodnih karakteristika i ekosustava. Time se osigurava dugoročno i održivo korištenje morskih resursa na dobrobit sadašnjih i budućih generacija. Pomorska industrija suočava se sa značajnim izazovima u nastojanju da smanji emisije ugljikovog dioksida. Međunarodna pomorska organizacija prepoznala je obraštanje kao veliki problem s ekološkog i ekonomskog aspekta. Obraštaj narušava ekološku ravnotežu svjetskih oceana omogućujući širenje invazivnih vrsta, dok istovremeno narušava hidrodinamičke značajke brodova. To dovodi do povećanja zahtijevane snage, potrošnje goriva i emisija stakleničkih plinova. Cilj ovog projekta je razviti metodologiju koju je moguće učinkovito primijeniti za optimizaciju rasporeda održavanja trupa trajekata koji svakodnevno plove na lokalnim linijama između otoka i kopna u Jadranskom moru, a koja se može lako proširiti i na druge vrste brodova. Određivanje optimalnih strategija održavanja u jedinstvenom morskom okolišu poput Jadranskog mora predstavlja izazov, jer zahtijeva uzimanje u obzir različitih čimbenika, uključujući značajke broda, operativne profile i okolišne uvjete. Istraživanje će obuhvatit hidrodinamičko modeliranje, računalnu dinamiku fluida, predviđanje rasta obraštaja, termodinamički model rada brodskog dizelskog motora te analizu troškova životnog ciklusa kako bi se procijenili ekološki i ekonomski učinci obraštaja na radne značajke broda i optimizirale strategije održavanja trupa. Dobiveni rezultati pomoći će će brodovlasnicima i operaterima u odabiru najodrživijih strategija održavanja trupa, poboljšanju operativne učinkovitosti te osiguravanju usklađenosti s ekološkim propisima. U konačnici, ovo istraživanje pridonijet će održivosti pomorskog prometa povećanjem energetske učinkovitosti i smanjenjem ugljičnog otiska u Jadranskom moru.]]></summary_hr><summary_en><![CDATA[The Adriatic Sea holds strategic significance for the Republic of Croatia, and its protection is essential for preserving and restoring its natural characteristics and ecosystems. This ensures the long-term, sustainable use of marine resources for the benefit of present and future generations. The maritime industry faces substantial challenges in its efforts to decarbonize. The International Maritime Organization has recognized marine biofouling as a major issue from both economic and ecological perspectives. Biofouling disrupts the ecological balance of the world&#39;s oceans by facilitating the spread of invasive aquatic species, while also degrading the hydrodynamic performance of ships, leading to propulsion powering penalties, higher fuel consumption, and increased greenhouse gas emissions. This project aims to develop a methodology that can be effectively applied to optimize the hull maintenance schedule for ferries operating daily on local routes between islands and the mainland in the Adriatic Sea but could be easily extended to other ship types as well. Determining optimal maintenance strategies in unique maritime environments like the Adriatic Sea is challenging, as it should consider various aspects, including ship characteristics, operational profiles, and environmental conditions. The research will integrate hydrodynamic modeling, computational fluid dynamics, biofouling growth prediction, thermodynamic model of the marine diesel engine, and Life Cycle Assessment to evaluate the environmental and economic impacts of biofouling on ship performance and optimize hull maintenance strategies. The findings will support shipowners and operators in selecting the most sustainable hull maintenance strategies, improving operational efficiency, and ensuring compliance with environmental regulations. Ultimately, this research will contribute to maritime transport sustainability by enhancing energy efficiency and reducing the carbon footprint in the Adriatic Sea.]]></summary_en></project><project>
<id>18761</id><title_hr><![CDATA[Holistic Approach towards Empowerment of the DiGitalization of the Energy Ecosystem through adoption of IoT solutions (HEDGE-IoT)]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5633</user_id><user_firstLast_name>Božidar Filipović-Grčić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-9618</code><acronim><![CDATA[]]></acronim><duration>05.11.2025 - 04.11.2031</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>872896</team_members_id><team_members_names><![CDATA[ Doktorand: Marta Đurović ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>18762</id><title_hr><![CDATA[Inovativni vinifikacijski postupci u funkciji povećanja biološkog i nutritivnog potencijala vina i nusproizvoda vinifikacije autohtonih i introduciranih sorti vinove loze]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6511</user_id><user_firstLast_name>Sanja Radeka</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-4902</code><acronim><![CDATA[VinNutriVit]]></acronim><duration>07.10.2025 - 06.10.2030</duration><status>U tijeku</status><financ_value>60,00 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Biotehnologija, </scie_field_hr><scie_field_en>Biotechnology, </scie_field_en><institution_hr><![CDATA[Institut za poljoprivredu i turizam]]></institution_hr><institution_en><![CDATA[Institute of Agriculture and Tourism in Poreč]]></institution_en><team_members_id>872826</team_members_id><team_members_names><![CDATA[ Doktorand: Laura Banović ]]></team_members_names><keywords_hr><![CDATA[inovativni vinifikacijski postupci, autohtone i introducirane sorte, vino, nusproizvodi vinifikacije, biološki potencijal, nutritivna svojstva]]></keywords_hr><keywords_en><![CDATA[innovative vinification procedures, autochthonous and introduced varieties, wine, vinification by-products, biological potential, nutritive properties]]></keywords_en><summary_hr><![CDATA[Inovativne tehnologije, poput ultrazvuka (sonikacija), usprkos visokoj učinkovitosti u ekstrakciji fenolnih, aromatskih i nutritivnih spojeva, relativno malo se koriste u vinarstvu. Stoga bi njihova primjena u vinarskoj proizvodnji mogla postati važna tehnološka inovacija za ubrzavanje relativno sporih procesa kao što je maceracija masulja. Također, proizvodnja vina neizbježno generira nusproizvode vinifikacije, koji se uobičajeno smatraju otpadom, iako se zbog visokog sadržaja polifenola, vlakana, antioksidativnog i antimikrobnog potencijala, mogu učinkovito koristiti u prehrambenom sektoru kao funkcionalna hrana. Cilj ovog projekta je istražiti kako inovativne vinifikacijske tehnologije u proizvodnji vina autohtonih hrvatskih sorti Malvazije istarske i Terana, te introduciranih sorti Graševine i Merlota,  mogu utjecati na bioaktivni, antimikrobni i nutritivni potencijal dobivenih vina i nusproizvoda, te istražiti mogućnosti njihove primjene u protektivne i prehrambene svrhe. U proizvodnji vina navedenih sorti primijenit će se tretmani sonikacije masulja različitih frekvencija ultrazvučnih valova i duljina trajanja. Proizvedena vina i nusproizvodi podvrgnut će se analizi aromatskih i fenolnih spojeva, antioksidacijskog i nutritivnog potencijala, te će biti senzorno ocjenjena. Podaci o kemijskom, bioaktivnom i nutritivnom sastavu vina i nusproizvoda proizašli iz ovog istraživačkog projekta, omogućit će bolje razumijevanje kemijskih i biokemijskih procesa do kojih dolazi primjenom određenih vinifikacijskih tehnika, dok će senzorna analiza proizvedenih vina i nusproizvoda vinifikacije potvrditi njihovu organoleptičku prihvatljivost i zdravstvenu ispravnost s ciljem dobivanja novog proizvoda. Budući da se neadekvatno zbrinuta komina grožđa smatra ekološkim problemom, mogućnosti iskorištenja nusproizvoda vinifikacije u nutritivne i protektivne svrhe, omogućilo bi dobivanje proizvoda s dodanom vrijednošću u kontekstu kružnog, održivog gospodarstva.]]></summary_hr><summary_en><![CDATA[Innovative technologies, such as ultrasound (sonication), despite their high efficiency in extracting phenolic, aromatic and nutritional compounds, are rarely used in winemaking. Therefore, their application in wine production could become an important technological innovation for speeding up relatively slow processes such as grape maceration. Wine production inevitably generates vinification by-products, which are usually considered waste, although due to the high content of polyphenols, fiber, antioxidant, and antimicrobial potential, they can be effectively used in the food sector as functional food. The aim of this project is to investigate the effect of innovative vinification technologies when producing wines from autochthonous Croatian varieties Malvazija istarska and Teran, and introduced varieties Graševina and Merlot, on the bioactive, antimicrobial and nutritional potential of the resulting wines and by-products. Moreover, the aim is to explore the possibilities of their application in protective and nutritional purposes. Sonication treatments of different frequencies and durations of ultrasonic waves will be applied in the production of wines of the mentioned varieties.  Aromatic and phenolic compounds, antioxidant and nutritional potential and sensory profile of the produced wines will be analysed. Data on chemical, bioactive and nutritional composition of wine and by-products will enable a better understanding of the chemical and biochemical processes that occur through the application of certain vinification techniques, while the sensory analysis of the produced wines and vinification by-products will confirm their organoleptic acceptability and safety with the aim of obtaining a new product. Since inadequately managed grape pomace is considered an ecological problem, the possibility of using vinification by-products for nutritional and protective purposes would provide products with added value in the context of a circular, sustainable economy.]]></summary_en></project><project>
<id>18763</id><title_hr><![CDATA[North Adriatic Hydrogen Valley]]></title_hr><title_en><![CDATA[]]></title_en><user_id>20175</user_id><user_firstLast_name>Ankica Kovač</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-3148</code><acronim><![CDATA[]]></acronim><duration>09.01.2026 - 08.01.2032</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, </scie_field_hr><scie_field_en>Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>873026</team_members_id><team_members_names><![CDATA[ Doktorand: Mislav Bogdan ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>18766</id><title_hr><![CDATA[Utjecaj promjene klime, korištenja zemljišta i poljoprivredne prakse na pojavu i ponašanje zagađivala u savskom prekograničnom vodonosniku]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5602</user_id><user_firstLast_name>Ozren Larva</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-1463</code><acronim><![CDATA[GWQualityPath2070]]></acronim><duration>22.01.2026 - 21.01.2031</duration><status>U tijeku</status><financ_value>60,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Rudarstvo, nafta i geološko inženjerstvo, </scie_field_hr><scie_field_en>Mining, petroleum and geological engineering, </scie_field_en><institution_hr><![CDATA[Hrvatski geološki institut]]></institution_hr><institution_en><![CDATA[Croatian Geological Survey]]></institution_en><team_members_id>873045</team_members_id><team_members_names><![CDATA[ Doktorand: Rahela Šanjek ]]></team_members_names><keywords_hr><![CDATA[nova onečišćivala, poljoprivredno opterećenje, distribucija starosti podzemne vode, numeričko modeliranje, klimatske promjene, nesigurnosti]]></keywords_hr><keywords_en><![CDATA[emerging contaminants, agricultural load, groundwater age distribution, numerical modelling, climate change, uncertainties ]]></keywords_en><summary_hr><![CDATA[Glavni cilj predloženog projekta je povećati razumijevanje sudbine onečišćujućih tvari poljoprivrednog podrijetla u prekograničnom savskom vodonosnom sustavu koji se proteže od Krškog do Zagreba. Koristit će se različite istraživačke tehnike i metode u sklopu terenskih istraživanja, uzorkovanja podzemnih voda, interpretacije laboratorijskih analiza uzoraka podzemnih voda i numeričkog modeliranja. Terenskim istraživanjima će se identificirati opažačke bušotine prikladne za uzorkovanje podzemnih voda, a uzorkovanje podzemnih voda provodit će se odgovarajućim tehnikama potrebnim za ciljanu laboratorijsku analizu. Interpretacija podataka o prisutnosti određenih onečišćujućih tvari u podzemnim vodama, rezultata testova procjeđivanja vode i pronosa tvari u lizimetrima, procjena starosti podzemne vode, te analiza utjecaja različitih scenarija klimatskih promjena i različitih poljoprivrednih praksi na podzemne vode korištenjem modela toka podzemne vode i pronosa otopljenih tvari, bit će dio kabinetskog rada. Nadalje, ispitat će se nesigurnost rezultata modeliranja. Klimatski scenariji propagirat će se kroz numeričke modele toka podzemne vode i pronosa otopljenih tvari, te će omogućiti identifikaciju dugoročnih trendova koncentracija dušikovih spojeva u podzemnim vodama u uvjetima klimatskih promjena.Očekuje se postizanje sljedećih ciljeva: i) identifikacija glavnih izvora nitrata i pesticida u podzemnoj vodi, ii) identifikacija mjera za preokret trenda onečišćenja podzemne vode uzrokovanog poljoprivredom i metodologije za učinkovitu procjenu provedenih mjera, iii) poboljšanje postojećeg modela obnavljanja podzemnih voda, iv) procjena unosa dušika i pesticida iz poljoprivrednog zemljišta u podzemne vode i evolucije nitrata u vodonosniku, v) procjena utjecaja korištenja zemljišta i klimatskih promjena na dinamiku i kakvoću podzemnih voda i vi) utvrđivanje glavnih izvora nesigurnosti vezanih uz procjenu utjecaja klimatskih promjena.]]></summary_hr><summary_en><![CDATA[The main goal of the proposed project is to increase the understanding of the fate of pollutants of agricultural origin in the transboundary Sava aquifer system, which extends from Krško to Zagreb. Different investigation techniques and methods will be utilised in field investigation, groundwater sampling, interpretation of laboratory analyses of groundwater samples and numerical modelling. Field investigations will be performed to identify suitable observation wells for groundwater sampling campaigns and groundwater sampling will be carried out using the appropriate techniques required for the targeted laboratory analysis. Interpretation of data on the presence of certain pollutants in groundwater, the results of leakage tests on lysimeters, groundwater age assessment, and the analysis of the impact of both different climate change scenarios and various agricultural practices on groundwater resources using groundwater flow and solute transport modelling, will be part of cabinet work. Furthermore, the uncertainty of modelling results will be investigated. The climate scenarios will be propagated in numerical groundwater flow and solute transport models and will enable the identification of long-term trends in concentrations of nitrogen species in groundwater under climate change.The following objectives are expected to be achieved: i) identification of the main sources of nitrates and pesticides in groundwater, ii) identification of the measures to reverse the trend in groundwater pollution from agriculture and methodology for effective evaluation of implemented measures, iii) improvement of the existing groundwater recharge model, iv) estimation of nitrogen and pesticide loads from agricultural land to groundwater and the evolution of nitrates in groundwater, v) assessment of the impact of land use and climate change on groundwater dynamics and quality and vi) identification of the main sources of uncertainty related to the assessment of climate change impacts.]]></summary_en></project><project>
<id>18768</id><title_hr><![CDATA[Međuodnos neuronalnog gangliozidoma i mitohondrijskog energetskog metabolizma]]></title_hr><title_en><![CDATA[]]></title_en><user_id>12492</user_id><user_firstLast_name>Kristina Mlinac Jerković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-8699</code><acronim><![CDATA[NEUROGEM]]></acronim><duration>01.12.2025 - 30.11.2031</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>872959</team_members_id><team_members_names><![CDATA[ Doktorand: Adriana Lipovčić ]]></team_members_names><keywords_hr><![CDATA[gangliozidi, glikosfingolipidi, energetski metabolizam mozga, ionski transporteri, ATPaza]]></keywords_hr><keywords_en><![CDATA[gangliosides, glycosphingolipids, brain energy metabolism, ion transporters, ATPase]]></keywords_en><summary_hr><![CDATA[Biosinteza gangliozida, dominantnih odrednica glikoma mozga sisavaca, je složen proces u koji su uključene specifične glikoziltransferaze. Upravo su mutacije u genima za pojedine glikoziltransferaze uzrok bolesti svrstanih u skupinu urođenih poremećaja glikozilacije (UPG). Međutim, još nije razjašnjena patološka kaskada koja povezuje genski uvjetovane poremećaje sinteze gangliozida s njihovim molekularnim i kliničkim fenotipom obilježenim mitohondrijskom disfunkcijom, epileptičkim napadajima, zastojem u razvoju i kognitivnim zaostajanjem. Opisani molekularni fenotip UPG jasno ukazuje na povezanost gangliozida s mitohondrijskim metabolizmom, stoga je jedan od ciljeva projekta provesti detaljnu strukturnu karakterizaciju gangliozida mitohondrijskih membrana i reinterpretirati uvriježeno stajalište o gangliozidima kao količinski i funkcionalno zanemarivim sastojcima mitohondrijskih membrana. Glavni cilj je razjasniti kako promjena sastava gangliozida stanične i mitohondrijske membrane dovodi do mitohondrijske disfunkcije i poremećaja u energetskom metabolizmu neurona. U tu svrhu koristit ćemo ciljanu inaktivaciju gena uključenih u biosintezu gangliozida pomoću CRIPSR-Cas9 tehnologije in vitro čime ćemo generirati biblioteke izogeničnih stanica s različitim sastavom gangliozida. U tako modificiranim ljudskim i mišjim neuronalnim staničnim linijama pratit ćemo izražaj i aktivnost odabranih ionskih transportera, enzima i proteina energetskog metabolizma stanice, koncentraciju odabranih metabolita i iona te fiziološku funkcionalnost mitohondrija. Uspostavljanje ovih staničnih linija predstavlja vrijedan resurs dostupan za istraživanja uloga gangliozida izvan okvira predloženog projekta. Projekt će doprinijeti razumijevanju molekularnog mehanizma uključenog u razvoj urođenih poremećaja glikozilacije, a jedan od očekivanih rezultata je identifikacija potencijalnih novih terapijskih ciljeva u neurološkim poremećajima praćenima narušenom homeostazom energetskog metabolizma.]]></summary_hr><summary_en><![CDATA[Gangliosides, considered as dominant determinants of the mammalian brain glycome, are synthesized in a complex process requiring specific glycosyltransferases. Certain congenital disorders of glycosylation (CDGs) are caused by gene mutations of several of these glycosyltransferases. However, clarification of the pathological cascade linking genetic disorders of ganglioside synthesis to their molecular and clinical phenotype, characterized by mitochondrial dysfunction, epileptic seizures, and delayed physical and cognitive development, is still not elucidated. Since described CDGs’ molecular phenotype speaks in favour of gangliosides being involved in mitochondrial metabolism, one of the project goals is to structurally characterize gangliosides of the mitochondrial membranes and to offer a reinterpretation of the standpoint about gangliosides as functionally negligible constituents of mitochondrial membranes. The main project objective is to determine how altered gangliosidome of cellular and mitochondrial membranes leads to mitochondrial dysfunction and neuronal energy metabolism disturbances. For this purpose, we will use targeted inactivation of ganglioside biosynthetic genes by CRIPSR-Cas9 technology in vitro, generating sublibraries of isogenic cells with different ganglioside composition. In the modified neuronal human and murine cell lines we will analyse the expression and activity of selected ion transporters, enzymes and proteins involved in cell energy metabolism, the concentration of metabolites and ions, and physiological mitochondrial function. The establishment of the proposed cell lines represents a valuable resource for long-term research of ganglioside physiological roles beyond the scope of the project. The project will contribute to clarification of the molecular mechanism underlying CDGs and ultimately lead to the identification of potential new therapeutic targets in neurological disorders accompanied by impaired energy metabolism homeostasis.]]></summary_en></project><project>
<id>18769</id><title_hr><![CDATA[Developing skills for introducing circular business models and digital technologies in olive oil sector - CIRCOLIVE]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5679</user_id><user_firstLast_name>Karolina Brkić Bubola</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-8478</code><acronim><![CDATA[]]></acronim><duration>01.11.2025 - 31.10.2030</duration><status>U tijeku</status><financ_value>60,00 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Prehrambena tehnologija, </scie_field_hr><scie_field_en>Food technology, </scie_field_en><institution_hr><![CDATA[Institut za poljoprivredu i turizam]]></institution_hr><institution_en><![CDATA[Institute of Agriculture and Tourism in Poreč]]></institution_en><team_members_id>870362</team_members_id><team_members_names><![CDATA[ Doktorand: Iva Pastor ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>18771</id><title_hr><![CDATA[Sintetički projektni hidrogrami u uvjetima sadašnje i buduće klime za procjenu lokalnog podlokavanja oko mostova]]></title_hr><title_en><![CDATA[]]></title_en><user_id>20384</user_id><user_firstLast_name>Kristina Potočki</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-4645</code><acronim><![CDATA[SERIOUS]]></acronim><duration>02.01.2026 - 01.01.2032</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Građevinarstvo, </scie_field_hr><scie_field_en>Civil engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Građevinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Civil Engineering]]></institution_en><team_members_id>872969</team_members_id><team_members_names><![CDATA[ Doktorand: Fran Vuić ]]></team_members_names><keywords_hr><![CDATA[sintetički projektni hidrogrami, hidrološko modeliranje, klimatske promjene, podlokavanje, most]]></keywords_hr><keywords_en><![CDATA[synthetic design hydrographs, hydrologic modelling, climate change, scour, bridge]]></keywords_en><summary_hr><![CDATA[Cilj SERIOUS projekta je odgovoriti na istraživačko pitanje je li moguće generirati sintetičke projektne hidrograme (SPH) na temelju statističke bivarijantne analize poplavnih događaja pod sadašnjim i budućim klimatskim uvjetima u kontinentalnom dijelu Hrvatske (dio sliva Dunava) te njihova primjena u procjeni utjecaja klimatskih promjena na podlokavanje oko mostova na odabranim pilot lokacijama. Klimatske promjene dovode do intenzivnijih poplavnih događaja čime se bitno mijenjaju morfodinamički uvjeti u riječnom koritu, što dovodi do narušavanja stabilnosti građevina smještenih u vodotoku, a posebice mostova. U dosadašnjim istraživanjima uočena je potreba za unapređenjima u metodološkom pristupu u svrhu smanjenja neizvjesnosti prilikom modeliranja utjecaja klimatskih promjena, hidrološkog modeliranja i modeliranja lokalnog podlokavanja oko stupova mosta. Unutar projekta bit će uspostavljen metodološki okvir za određivanje kontrolnog SPH na temelju pregleda literature i dostupnih podataka na odabranim pilot područjima u Hrvatskoj, gdje će se koristiti algoritmi nadziranog i/ili nenadziranog strojnog učenja za određivanje različitih tipova SPH na temelju različitih oblika i topologija. Koristit će se hidrološki model s projekcijama klimatskih promjena iz CMIP5 ili CMIP6 kako bi se odredile promjene u SPH. Cilj je metodološki povezati klimatske promjene s lokalnim podlokavanjem razvijanjem metodologije za procjenu utjecaja klimatskih promjena na karakteristike poplavnih valova, proračunavanjem lokalnog podlokavanja oko stupova mostova na toj osnovi i usporedbom pouzdanosti dobivenih rezultata s izmjerenim vrijednostima. Rezultati projekta koristit će stručnjacima u području hidrauličnog i riječnog inženjerstva, javnim tijelima koja upravljaju prometnom infrastrukturom i mostovima, kao i hidrološkoj praksi u Hrvatskoj, kroz poboljšanu metodologiju za određivanje SPH, koji služe kao ulazni podatak za projektiranje različitih hidrotehničkih građevina.]]></summary_hr><summary_en><![CDATA[The aim of the SERIOUS project is to answer the research question whether it is possible to establish synthetic design hydrographs (SDH) based on a statistical bivariate analysis of flood events under the current and future climate in the continental part of Croatia (part of the Danube River Basin) and apply them for the assessment of climate change impacts on bridge scour at the selected pilot sites. Climate change leads to more intense flood events, which significantly change the morphodynamic conditions in rivers and thus jeopardize the stability of structures in the watercourse, especially bridges. Previous research has shown that methodological approaches need to be improved to reduce uncertainties in modelling the effects of climate change, hydrological modelling and modelling of local scour around bridge piers. Within the project, methodological framework for determining control synthetic design hydrograph based on the literature review and available data in selected pilot areas in Croatia will be established, where algorithms of supervised and/or unsupervised machine learning will be used to determine the different SDH types based on the different shapes and topologies. Hydrological model with climate change projections from the CMIP5 or CMIP6 will be used to estimate changes in SDH. The aim is to methodologically link climate change to local scour by developing a methodology to assess the influence of climate change on flood wave characteristics, calculating local scour around bridge piers on this basis and comparing the reliability of the obtained results with measured values. The project results will benefit hydraulic and river engineering experts, public entities managing transportation infrastructure and bridges, as well as hydrological practices in Croatia through an improved methodology for determining SDH, which serves as input data for the design of various water engineering structures.]]></summary_en></project><project>
<id>18776</id><title_hr><![CDATA[Sinergija primjene inteligentnih metoda u procjeni ponašanja zgrada, elemenata i materijala i inovativna uporaba recikliranih građevinskih materijala zasnovana na eksperimentalnim i novim pristupima za uspostavu održivog životnog prostora]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4092</user_id><user_firstLast_name>Marijana Hadzima-Nyarko</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-9828</code><acronim><![CDATA[]]></acronim><duration>09.12.2025 - 08.12.2031</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Građevinarstvo, </scie_field_hr><scie_field_en>Civil engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Građevinski i arhitektonski fakultet Osijek]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Civil Engineering and Architecture Osijek]]></institution_en><team_members_id>872991</team_members_id><team_members_names><![CDATA[ Doktorand: Antonija Ereš ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>18777</id><title_hr><![CDATA[The Cartography of the Political Novel in Europe (CAPONEU, Horizon Europe)]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5581</user_id><user_firstLast_name>Zrinka Božić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-9368</code><acronim><![CDATA[]]></acronim><duration>15.12.2025 - 14.12.2031</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filologija, </scie_field_hr><scie_field_en>Philology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>873010</team_members_id><team_members_names><![CDATA[ Doktorand: Filip Kučeković ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>18781</id><title_hr><![CDATA[Improving degree of conservation of Natura 2000 target species and habitat types through improvement of river connectivity (LIFE22-NAT-HR-Improve River LIFE)]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5671</user_id><user_firstLast_name>Ivan Čanjevac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-9933</code><acronim><![CDATA[]]></acronim><duration>29.01.2026 - 28.01.2032</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Interdisciplinarno područje znanosti</scie_area_hr><scie_area_en>Interdisciplinary scientific area</scie_area_en><scie_field_hr>Geografija, </scie_field_hr><scie_field_en>Geography, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>873103</team_members_id><team_members_names><![CDATA[ Doktorand: Jura Sabolek ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>18784</id><title_hr><![CDATA[Od mora do vrha: održivo upravljanje osjetljivim krškim vodonosnicima pod klimatskim promjenama i antropogenim stresom]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6042</user_id><user_firstLast_name>Ivo Andrić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-9196</code><acronim><![CDATA[Sea2Summit]]></acronim><duration>11.11.2025 - 11.11.2031</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Građevinarstvo, </scie_field_hr><scie_field_en>Civil engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu Fakultet građevinarstva, arhitekture i geodezije]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Civil Engineering, Architecture and Geodesy]]></institution_en><team_members_id>872950</team_members_id><team_members_names><![CDATA[ Doktorand: Kajo Podrug ]]></team_members_names><keywords_hr><![CDATA[Hidrogeologija, Hidrologija, Krš, Ledenjak, Otok, Vodoopskrba]]></keywords_hr><keywords_en><![CDATA[Hydrogeology, Hidrology,  Karst, Glacier, Island, Water Supply]]></keywords_en><summary_hr><![CDATA[Izvori pitke vode u planinskim područjima i na malim otocima iznimno su osjetljivi na učinke klimatskih promjena. Na prve utječe otapanje ledenjaka na velikim nadmorskim visinama, na druge podizanje razine mora i prodor slane vode u obalna područja. Dok su porozni vodonosnici sposobni odigrati važnu ulogu skladištenja i tampona, krške zone su mnogo reaktivnije i na njih ti čimbenici jače utječu. Krški slatkovodni resursi su visoko ugroženi klimatskim promjenama. Uz to, razvoj turizma dodatno povećava antropogeni pritisak na te resurse. Razumijevanje dinamike ovih sustava stoga je bitno za stanovništvo koje živi u tim sredinama.Projekt predlaže proučavanje dva mjesta koja detaljno prikazuju ove situacije. Prvi je otok Vis u Hrvatskoj, a drugo područje krški vodonosnik Tsanfleuron, koji opskrbljuje grad Conthey pitkom vodom. Za ove dvije regije, Sveučilište u Splitu i Sveučilište u Neuchâtelu predlažu udruživanje svoje komplementarne ekspertize kako bi se detaljno analiziralo stanje u ova dva slučaja, kako bi se predvidjeli mogući učinci klimatskih promjena prema različitim scenarijima koje je predstavio IPCC, te utvrditi kako ove prognoze treba pretočiti u mjere prilagodbe i ublažavanja utjecaja. Stoga je prvi cilj pokrenuti, nastaviti ili proširiti okvir praćenja obaju mjesta i karakterizirati te sustave s geološkog i hidrogeološkog stajališta te modeliranje opisanih procesa. Testiraju se različiti klimatski scenariji i strategije upravljanja u svrhu kreiranja operativnih politika koje vlasti mogu implementirati na ova dva mjesta. Osim specifičnog proučavanja ovih mjesta, primijenjene metode i rezultati promatranja trebali bi poslužiti kao osnova za rješavanje ove vrste problema za druga slična nalazišta diljem svijeta.]]></summary_hr><summary_en><![CDATA[Drinking water resources in mountain areas and on small islands are extremely sensitive to the effects of climate change. The former are affected by melting glaciers at high altitudes, the latter by rising sea levels, and saltwater intrusion in coastal areas. While porous or fractured aquifers are capable of playing an important storage and buffering role, karst zones are much more reactive, and are affected more violently by these factors. Karstic freshwater resources are highly threatened by climate change. In addition, the touristic development is adding further anthropogenic pressure on these resources. Understanding the dynamics of these systems is therefore essential for the populations living in these environments.The project proposes to study two sites that encapsulate these situations in detail. The first is the island of Vis in Croatia and the second site is the Tsanfleuron karstic aquifer, which supplies the town of Conthey with drinking water. For these two regions, the University of Split and the University of Neuchâtel propose to pool their complementary expertise to analyse the situation in detail in these two cases, to forecast the possible impacts of climate change according to the different scenarios presented by the IPCC, and identify how these forecasts should be translated into adaptation and impact mitigation measures. The first aim is therefore to launch, resume, or extend the monitoring framework of both sites and characterise these systems from a geological and hydrogeological standpoint and system modelling. Various climate scenarios and management strategies will be tested to eventually translate them into operational policies that the authorities can implement at these two sites. Beyond the specific study of these sites, the methods implemented and the results of the observations should serve as a basis for solving these types of problems for other similar sites around the world.]]></summary_en></project><project>
<id>18785</id><title_hr><![CDATA[Genetska i epigenetska regulacija ponašanja induciranog metamfetaminom u D. melanogaster]]></title_hr><title_en><![CDATA[]]></title_en><user_id>69</user_id><user_firstLast_name>Rozi Andretić Waldowski</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-2115</code><acronim><![CDATA[METH2GENE]]></acronim><duration>08.12.2025 - 07.12.2031</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Interdisciplinarno područje znanosti</scie_area_hr><scie_area_en>Interdisciplinary scientific area</scie_area_en><scie_field_hr>Biotehnologija u biomedicini, </scie_field_hr><scie_field_en>Biotechnology in Biomedicine, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci]]></institution_hr><institution_en><![CDATA[University of Rijeka]]></institution_en><team_members_id>872962</team_members_id><team_members_names><![CDATA[ Doktorand: Antea Marjanović ]]></team_members_names><keywords_hr><![CDATA[geni, epigenetika, ovisnost, metamfetamin, genska regulacija, D. melanogaster]]></keywords_hr><keywords_en><![CDATA[genes, epigenetics, addiction, methamphetamine, gene regulation, D. melanogaster]]></keywords_en><summary_hr><![CDATA[Okolina utječe na epigenetsku modifikaciju kromatina, ekspresiju gena i dovodi do dugoročnih promjena u funkcioniranju mozga. Zlouporaba droga izaziva modifikacije DNA i histona, uzrokuje promjene u genskoj ekspresiji, a time i neuronskoj plastičnosti što definira simptome ovisnosti. U usporedbi sa sisavcima, ništa se ne zna o epigenetskim modifikacijama izazvanim metamfetaminom (METH) u D. melanogaster. To je propust jer D. melanogaster dijeli 64% genetske sličnosti s ljudima i posljednjih desetljeća opsežno se koristi kao model za proučavanje ljudskih bolesti, uključujući ovisnost.Mi smo pokazali da višestruka izloženost volatiliziranom METH-u (vMETH) u mušica dovodi do fenotipske ekspresije neuronske plastičnosti, te da genetske intervencije koje remete redoks ravnotežu sprječavaju njen razvoj. Proteomska analiza pokazuje da vMETH mijenja količinu proteina koji sudjeluju u regulaciji staničnog metabolizma, redoks ravnoteže i epigenetskih promjena, što smo potvrdili farmakološkim i biokemijskim pokusima. To ukazuje da metabolizam i oksidativni status utječu na epigenetske modifikacije inducirane METH-om. Hipotezu ćemo testirati na mušicama izloženim vMETH-u i na sojevima koje smo dobili pomoću umjetne selekcije za samoadministraciju METH-a, soju s visokom preferencijom (HP) i visokom averzijom (HA).Naš glavni cilj je opisati kako METH dovodi do epigenetskih promjena u D. melanogaster što će pružiti smjernice za translacijske studije koje će pomoći u liječenju ovisnosti. Da bismo to postigli koristiti ćemo najsuvremenije tehnike za nepristranu identifikaciju svih posttranslacijskih modifikacija na histonima i definirati područja odmotanog kromatina koja su permisivna za ekspresiju gena. Dobiveni podaci pomoći će nam u formuliranju hipoteza istraživanja u kojima ćemo korelirati biokemijske, genetske i farmakološke manipulacije s fenotipskim promjenama. Cilj je steći razumijevanje molekularnih mehanizama koji povezuju zlouporabu METH-a s promjenama u ponašanju.]]></summary_hr><summary_en><![CDATA[The environment affects epigenetic modification of chromatin, gene expression and leads to long-term changes in brain functioning. Drug abuse causes modifications of DNA and histones, changes in gene expression  and neuronal plasticity, which defines the symptoms of addiction. Compared to mammals, nothing is known about methamphetamine (METH)-induced epigenetic modifications in D. melanogaster. This is an omission because D. melanogaster shares 64% genetic similarity with humans and has been used extensively in recent decades as a model to study human diseases, including addiction.We have shown that multiple exposure to volatilized METH (vMETH) in flies leads to the phenotypic expression of neuronal plasticity, and that genetic interventions that disturb the redox balance are preventing it. Proteomic analysis shows that vMETH changes the amount of proteins involved in the regulation of cellular metabolism, redox balance and epigenetic changes, which we confirmed with pharmacological and biochemical experiments, indicating that metabolism and oxidative status influence METH-induced epigenetic modifications. We will test the hypothesis in flies exposed to vMETH and in strains obtained by selection for METH self-administration, a high preference (HP) and a high aversion (HA) strain.Our main goal is to describe how METH leads to epigenetic changes in D. melanogaster that will provide guidance for translational studies that will help in the treatment of addiction. In order to achieve this, we will use state-of-the-art techniques for the unbiased identification of all post-translational modifications on histones and define regions of unwound chromatin that are permissive for gene expression. The obtained data will help us formulate research hypotheses in which we will correlate biochemical, genetic and pharmacological manipulations with phenotypic changes. The goal is to gain an understanding of the molecular mechanisms that link METH abuse to behavioral changes.]]></summary_en></project><project>
<id>18786</id><title_hr><![CDATA[Swarm of Energy Harvesting Floaters for the Detection of Vessel threats (SHIELD) WP3 - Acoustic detection]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5962</user_id><user_firstLast_name>Nikola Mišković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-5624</code><acronim><![CDATA[]]></acronim><duration>05.11.2025 - 04.11.2031</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Temeljne tehničke znanosti, </scie_field_hr><scie_field_en>Basic engineering sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>872923</team_members_id><team_members_names><![CDATA[ Doktorand: Dorian Možnik ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>18787</id><title_hr><![CDATA[Model demografske otpornosti lokalnih zajednica Hrvatske: teorijsko-metodološka konceptualizacija i razvoj alata za učinkovito upravljanje]]></title_hr><title_en><![CDATA[The Model of Demographic Resilience of Local Communities in Croatia: Theoretical-Methodological Conceptualization and Development of Tools for Effective Management]]></title_en><user_id>25736</user_id><user_firstLast_name>Nikola Šimunić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2025-02</proposal_call><code>UIP-2025-02-8894</code><acronim><![CDATA[DEMRES-HR]]></acronim><duration>19.02.2026 - 18.02.2031</duration><status>U tijeku</status><financ_value>300.000,00 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Demografija, Ekonomija, Informacijske znanosti, </scie_field_hr><scie_field_en>Demography, Economy, Information sciences, </scie_field_en><institution_hr><![CDATA[Ništa od navedenog]]></institution_hr><institution_en><![CDATA[Nothing from this list]]></institution_en><team_members_id>870092, 869959, 27009, 27261, 27228, 24201, </team_members_id><team_members_names><![CDATA[Monika Komušanac, Maja Vizjak, Goran Zaharija, Iva Tadić Tadić, Tomislav Belić, Luka  Šikić, ]]></team_members_names><keywords_hr><![CDATA[demografska otpornost, GIS, gradovi/općine, Hrvatska, strojno učenje, višekriterijska analiza]]></keywords_hr><keywords_en><![CDATA[demographic resilience, GIS, cities/municipalities, Croatia, machine learning, multi-criteria analysis]]></keywords_en><summary_hr><![CDATA[Temeljna svrha projekta jest osnovati samostalnu istraživačku grupu koja bi povezala znanstvene discipline demografiju, geografiju i ekonomiju. Cilj ovog projekta je razvoj novog teorijsko-metodološkog okvira za mjerenje demografske otpornosti gradova i općina te izrada interaktivnog GIS alata za analizu i upravljanje demografskim procesima. Demografska otpornost postaje ključan koncept u upravljanju demografskim izazovima, osobito u kontekstu Hrvatske, koja se suočava s padom fertiliteta, migracijama i depopulacijom. Primjenom složenih statističkih metoda i prostorne ekonometrije istražit će se ključni čimbenici demografske otpornosti i njihova prostorna distribucija. Rezultati će omogućiti kreiranje politika usmjerenih na smanjenje regionalnih dispariteta i prilagodbu lokalnih zajednica na demografske promjene. Multidisciplinarni pristup i inovativne metode osigurat će dublje razumijevanje demografske dinamike i pružiti alat za strateško planiranje na nacionalnoj i lokalnoj razini. Analizi će se podvrgnuti cjelokupan prostor Republike Hrvatske, na razini gradova i općina (556), kao studija slučaja na rubu europskoga šengenskog prostora. Demografska problematika je temeljna društvena problematika svih zemalja Europske unije, a naročito Hrvatske. U suvremenim uvjetima, kad su disbalansi sve prisutniji (recesije, geopolitičke krize, potresi), razumijevanje otpornosti lokalnih zajednica je od prvorazrednog značaja za pametno upravljanje procesom oporavaka. Na lokalnoj razini su prisutne varijabilnosti koje će ovim projektom biti istražene, te će se postaviti temelji za buduća istraživanja otpornosti lokalnih zajednica. Alat, koji se razvije iz ovog projekta, poslužit će državnim, regionalnim i lokalnim upravljačkim razinama u adresiranju javnih politika u procesu upravljanja oporavkom.]]></summary_hr><summary_en><![CDATA[The primary purpose of this project is to establish an independent research group that integrates the scientific disciplines of demography, geography, and economics. The project&#39;s goal is to develop a new theoretical-methodological framework for measuring the demographic resilience of cities and municipalities and to create an interactive GIS tool for analysing and managing demographic processes. Demographic resilience is becoming a key concept in addressing demographic challenges, particularly in Croatia, which faces declining fertility rates, migration, and depopulation. By applying advanced statistical methods and spatial econometrics, the project will investigate key factors of demographic resilience and their spatial distribution. The results will enable the creation of policies aimed at reducing regional disparities and adapting local communities to demographic changes. A multidisciplinary approach and innovative methods will provide a deeper understanding of demographic dynamics and offer a tool for strategic planning at national and local levels. The entire territory of the Republic of Croatia will be analysed at the level of cities and municipalities (556), serving as a case study on the periphery of the European Schengen area. Demographic issues are a fundamental social challenge for all EU countries, particularly for Croatia. In modern conditions, where imbalances are increasingly prevalent (recessions, geopolitical crises, earthquakes), understanding the resilience of local communities is of paramount importance for smart recovery management. At the local level, there are significant variations that this project will explore, laying the groundwork for future research on community resilience. The tool developed through this project will support national, regional, and local governance in addressing public policies related to recovery management.]]></summary_en></project><project>
<id>18788</id><title_hr><![CDATA[Infrastruktura istraživanja pomorske digitalizacije]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4930</user_id><user_firstLast_name>Mario Kušek</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-4136</code><acronim><![CDATA[]]></acronim><duration>15.12.2025 - 14.12.2031</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>872979</team_members_id><team_members_names><![CDATA[ Doktorand: Magdalena Šimunec ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>18791</id><title_hr><![CDATA[Umjetna inteligencija medicinskih uređaja]]></title_hr><title_en><![CDATA[Artificial Intelligence of Medical Things]]></title_en><user_id>7605</user_id><user_firstLast_name>Petar Šolić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-7836</code><acronim><![CDATA[AIoMT]]></acronim><duration>15.12.2025 - 14.12.2028</duration><status>U tijeku</status><financ_value>199.000,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, Elektrotehnika, </scie_field_hr><scie_field_en>Computer sciences, Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Fakultet elektrotehnike, strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Electrical Engineering, Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>22801, 13160, 7189, 4542, 868444, 868493, </team_members_id><team_members_names><![CDATA[Toni Perković, Ivo Stančić, Maja Škiljo, Ivana Pavlinac Dodig, Josip Krnić, Hrvoje Belani, ]]></team_members_names><keywords_hr><![CDATA[E-zdravlje, Internet stvari, Senzori, Velika količina podataka, Umjetna inteligencija]]></keywords_hr><keywords_en><![CDATA[E-health, IoT, Sensors, Big Data, Artificial Intelligence]]></keywords_en><summary_hr><![CDATA[Buduća medicina bit će prediktivna, preventivna, personalizirana i digitalna. Podaci i znanje moraju biti dostupni za istraživanje i pružanje skrbi, kao osnova za ciljanu dijagnostiku i terapiju. Stjecanje, integracija i dijeljenje podataka ključni su za ostvarenje tih ciljeva, uz korištenje visokokvalitetnih podataka i novih, energetski učinkovitih uređaja osnaženih algoritmima umjetne inteligencije (AI) za učinkovitu skrb pacijenata. Klinički Bolnički Centar u Splitu kao podržavatelj ovog projekta, koristi Bolnički informacijski sustav (BIS) - potpuno digitalizirani sustav koji omogućava pristup zdravstvenim zapisima pacijenata s digitalno dostupnim podacima i dokumentima. Sustav, kao takav podržava pisanje upita baze podataka za izvlačenje ciljanih informacija i sadrži brojne dobro strukturirane podatke koji se mogu koristiti za izgradnju velikog podatkovnog sustava orijentiranog istraživanju. Ovaj projektni prijedlog uključuje razvoj paralelnog sustava, zrcalne slike BIS-a pripremljenog za istraživačke potrebe, strukturiranog na način koji semantički opisuje pacijenta s relevantnim informacijama, omogućujući analizu podataka s ciljem poboljšanja dijagnostike i prognoze. Također projekt će iskoristiti znanje, razvijene tehnologije u području hardvera i softvera, te iskustava iz prethodnog, uspješno zaključenog uspostavnog projekta financiranog od Hrvatske zaklade za znanost (Interent stvari: istraživanja i primjene), s ciljem implementacije razvijenog znanja u nove sustave koji zajedno sa podacima iz BIS-a uz pomoć primjene algoritama umjetne inteligencije čine cjelinu kojom je cilj doći do novih znanja primjena u medicini i time unaprijediti skrb za pacijente. Projektni prijednog će osim izrade već spomenutog novog softverskog okruženja, kroz svoje trajanje dati i dva doprinosa sa primjenama podataka iz BIS-a, u smislu izrade novih uređaja, a vezanih za primjene u hitnoj medicini (astma) i medicini spavanja.]]></summary_hr><summary_en><![CDATA[Future medicine will be predictive, preventive, personalized and digital. Data and knowledge must be available for research and care provision, as a basis for targeted diagnostics and therapy. Data acquisition, integration and sharing are key to achieving these goals, using high-quality data and new, energy-efficient devices powered by artificial intelligence (AI) algorithms for effective patient care. The Clinical Hospital Center in Split, as a supporter of this project, uses the Hospital Information System (HIS) - a fully digitized system that enables access to patients&#39; health records with digitally available data and documents. The system, as such, supports writing database queries to extract targeted information of well-structured data that can be used to build a large data system for research purposes. This project proposal involves the development of a parallel system, a mirror image of HIS prepared for research purposes, structured in a way that semantically describes the patient with relevant information, enabling data analysis with the aim of improving diagnostics and prognosis. The project will also use knowledge, developed technologies in the field of hardware and software, and experiences from the previous, successfully concluded establishment project financed by the Croatian Science Foundation (Internet of things: research and applications), with the aim of implementing the developed knowledge in new systems that together with data from HIS with the help of the application of artificial intelligence algorithms form a whole whose goal is to gain new knowledge of applications in medicine and thereby improve the patient care. In addition to the creation of the already mentioned new software environment, the project front will also make two contributions with the application of data from HIS, in terms of the creation of new devices, related to applications in emergency medicine (asthma scenario) and sleep medicine.]]></summary_en></project><project>
<id>18793</id><title_hr><![CDATA[Transforming the Adriatic cosmos: insularity, connectivity and glocalized identities of pre-Roman Dalmatia (UIP-2020-02)]]></title_hr><title_en><![CDATA[]]></title_en><user_id>21192</user_id><user_firstLast_name>Marina Ugarković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-2659</code><acronim><![CDATA[]]></acronim><duration>10.11.2025 - 09.11.2030</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Arheologija, </scie_field_hr><scie_field_en>Archeology, </scie_field_en><institution_hr><![CDATA[Institut za arheologiju]]></institution_hr><institution_en><![CDATA[Institute of Archaeology in Zagreb]]></institution_en><team_members_id>865081</team_members_id><team_members_names><![CDATA[ Doktorand: Pio Domines Peter ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>18794</id><title_hr><![CDATA[Molekularno oplemenjivanje soje na svojstva kvalitete zrna]]></title_hr><title_en><![CDATA[Molecular breeding of soybean for grain quality traits]]></title_en><user_id>2923</user_id><user_firstLast_name>Ivan Pejić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-1913</code><acronim><![CDATA[SoyQ-TRAITS]]></acronim><duration>26.01.2026 - 25.01.2029</duration><status>U tijeku</status><financ_value>190.900,00 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, Interdisciplinarne biotehničke znanosti, </scie_field_hr><scie_field_en>Agriculture, Interdisciplinary biotechnical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Agronomski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Agriculture]]></institution_en><team_members_id>869733, 7754, 6287, 23630, 7671, </team_members_id><team_members_names><![CDATA[Luka Ivković, Hrvoje Šarčević, Jerko Gunjača, Hrvoje Kutnjak, Miroslav Bukan, ]]></team_members_names><keywords_hr><![CDATA[soja, oplemenjivanje, sadržaj proteina, sadržaj tripsin inhibitora, mapiranje QTL-ova, SNP]]></keywords_hr><keywords_en><![CDATA[soybean, breeding, protein content, trypsin inhibitors content, QTL mapping, SNP]]></keywords_en><summary_hr><![CDATA[Soja je globalno važan izvor proteina biljnog porijekla s kojime je Europa u velikom deficitu (uvozi > 90% vlastitih potreba). Međutim, Hrvatska je u puno boljoj poziciji jer ima samodostatnu proizvodnju i veliki je izvoznik i sjemena i finalnog proizvoda (zrna) soje. Do ulaska u EU Hrvatska je oko 80 % sjemena soje proizvodila sama i sa domaćim sortama stvorenim u hrvatskim oplemenjivačkim kućama. Još uvijek oko 50 % tržišta drže domaće kompanije i domaće sorte. Oplemenjivanje i sjemenarstvo soje djelatnosti su u kojima Hrvatska ima veliki tržišni udio i izvozni potencijal.Soja se u Europi i kod nas primarno proizvodi radi proizvodnje ulja i stočne hrane. U izboru sortimenta pažnja se primarno posvećuje visini i stabilnosti prinosa, a puno manje kvaliteti zrna. Uobičajeni sadržaj proteina aktualnih sorata znatno je ispod realnih mogućnosti. Isto tako, velika većina sorata na tržištu ima u zrelom zrnu visoki sadržaj tripsin inhibitora, komponenti koje djeluje antinutritivno, pa se u pripremi stočne hrane mora najprije vršiti termička obrada zrna (inaktivacija tripsin inhibitora). Ovo je povezano sa nižom probavljivosti hrane i značajnim troškovima. Oba navedena problema moguće je riješavati primjenom klasičnih metoda oplemenjivanja i postojeće germplazme soje, ali je napredak u selekciji vrlo spor. Primjenom metoda molekularnog oplemenjivanja moguće je brže i znatno preciznije provesti selekciju superiornih biljaka i linija.Suvremenim metodama genotipizacije (novi SoySNP-5k-chip) i fenotipizacije (NIR, HPLC i UAS) u  posebno razvijenim RIL populacijama (Recombinant Inbred Lines) očekuje se identificirati specifične genske regije povezane sa sadržajem proteina, ulja i tripsin inhibitora u zrnu soje. U slučaju supješne lokalizacije gena odgovornih za navedena svojstva, kreirati će se lako upotrebljivi specifični markeri za brzo i cjenovno pristupačno testiranje oplemenjivačkih populacija i soje na sadržaj sastavnica kvalitete zrna u postupku razvoja novih sorata.]]></summary_hr><summary_en><![CDATA[Soybean is a globally important source of plant proteins, and Europe imports > 90% of its own needs. However, Croatia has self-sufficient production and is a large exporter of both seeds and the final product (grains) of soybeans. Before joining the EU, Croatia produced about 80% of soybean seeds by itself and with domestic varieties created in Croatian breeding companies. Domestic companies and domestic varieties still hold around 50% of the market. Soybean breeding and seed production in Croatia have a large market share and export potential.In Europe and in our country, soybeans are primarily produced for oil and animal feed. In the selection of cultivars, attention is primarily paid to the height and stability of the yield, and much less to the quality of the grain. The protein content in large scale production is significantly below real possibilities. Also, the vast majority of varieties on the market have a high content of trypsin inhibitors in dry grains, components that have an antinutritive effect, so in the preparation of fodder the grains must first be thermally treated. This is associated with lower food digestibility and significant costs. These problems can be solved by applying classic breeding methods and existing soybean germplasm, but progress in selection is very slow. By applying molecular breeding, it is possible to do selection of superior plants and lines much more quickly and precisely.Modern methods of genotyping (new SoySNP-5k-chip) and phenotyping (NIR, HPLC and UAS) in specially developed RIL populations (Recombinant Inbred Lines) are expected to identify specific genome regions associated with protein, oil and trypsin inhibitor content in soybeans. In the case of successful localization of the genes responsible for the mentioned traits, easy-to-use specific markers will be created for quick and affordable testing of breeding populations and lines for the content of grain quality components in the process of developing new varieties.]]></summary_en></project><project>
<id>18795</id><title_hr><![CDATA[Metamorfna bespilotna letjelica visokih preformansi]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5244</user_id><user_firstLast_name>Stjepan Bogdan</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-9246</code><acronim><![CDATA[MetaMorpher]]></acronim><duration>12.11.2025 - 11.11.2031</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>872911</team_members_id><team_members_names><![CDATA[ Doktorand: Anja Bosak ]]></team_members_names><keywords_hr><![CDATA[bespilotne letjelice, meka robotika, inteligentni materijali, osmatranje okoliša, adaptivno upravljanje]]></keywords_hr><keywords_en><![CDATA[unmanned aerial vehicles, soft robotics, material intelligence, environmental sensing, adaptive control]]></keywords_en><summary_hr><![CDATA[Projektiranje nelinearne, energetski učinkovite, bespilotne letjelice (UAV), kao i upravljanje njezinim letom i dalje predstavlja istraživačk izazov. Ovaj projektni prijedlog istražit će dizajn i upravljanje bespilotnom letjelicom koja se temelji na metamorfozi između dva različita principa letenja - rotirajućih krila (rotatinf wings) i jedrenja (gliding). Aerodinamičke, energetske, senzorske, strukturalne i komunikacijske sposobnosti UAV-a bit će razmotrene kako bi cjelokupni sustav ispunio svoju ulogu. Sa znanstvene točke gledišta, projekt MetaMorpher iznimno je izazovan jer je ovo prvi put, koliko znamo, da se istražuju metamorfoze tijekom leta, od rotirajućih krila do jedrilice. Jasno je da takva promjena u strukturi bespilotne letjelice, prije svega, zahtijeva duboko razumijevanje dinamike leta i dizajna profila krila, tako da se koriste odgovarajući materijali (osobito u kontekstu novih razgradivih tvari) za strukturu, posebno krila, koja mogu podnijeti nagle promjene u otporu zraka i prilagoditi se različitim smjerovima i brzinama strujanja zraka. S tim u vezi znanje i iskustvo LSR EMPA tima u dizajnu UAV-a je ključno. Uspješan ishod u dizajnu konstrukcije imat će značajnu znanstvenu važnost za sve buduće pokušaje ka energetski učinkovitim letovima. Drugi izazov, koji je u fokusu tima LARICS UNIZG-FER, odnosi se na upravljanje bespilotnim letjelicama s promjenjivom strukturom. Postojeći algoritmi za upravljanje multirotorskim letjelicama i letjelicama s fiksnim krilima mogu se izravno implementirati samo tijekom dvije glavne faze leta MetaMorpher letjelice - polijetanja/slijetanja i jedrenja, dok prijelaz tijekom slobodnog pada zahtijeva dizajn namjenskog mehanizma upravljanja, kako bi UAV ostao stabilan i postigao unaprijed zadanu misiju.]]></summary_hr><summary_en><![CDATA[The design and control of highly nonlinear, energy efficient, Unmanned Aerial Vehicle (UAV) remains a challenging research field. This research proposal will explore the design and control of an aerial system based on metamorphosis between two different principles of flying - rotating wings and gliding. The aerodynamic, energetic, sensorial, materials and communicative capabilities of the UAV will be appropriately considered so that the overall system fulfills its purpose. From the scientific point of view, the MetaMorpher project is extremely challenging as this is the first time, to the best of our knowledge, that in-flight metamorphoses from rotating wings to gliding has been investigated. Clearly, such change in the UAV structure, first of all, requires deep understanding of flight dynamics and airfoil design so that appropriate materials (especially in context of novel degradable substances) are used for the structure, particularly wings, that can sustain abrupt change in drag and accommodate for various directions and speeds of the air. With that respect the know-how and the experience of the LSR EMPA team in UAV design is essential. Successful outcome of the structural design will have significant scientific importance for all future attempts towards energy efficient flights. Second challenge, that is in focus of LARICS UNIZG-FER team, is related to the control of UAV with changeable structure. Existing algorithms for rotorcraft and fixed wing control can be directly implemented only during two major phases of MetaMorpher flight - takeoff/landing and gliding, while transition during the freefall requires design of dedicated control mechanism, so that UAV stays stable and achieve predetermined mission.]]></summary_en></project><project>
<id>18796</id><title_hr><![CDATA[Center of Excellence in Maritime Robotics and Technologies for Sustainable Blue Economy (MARBLE)“, radni paket 7  „Broad Networking&#39;&#39;]]></title_hr><title_en><![CDATA[]]></title_en><user_id>24184</user_id><user_firstLast_name>Tamara Petrović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-9097</code><acronim><![CDATA[]]></acronim><duration>22.12.2025 - 21.12.2031</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>872938</team_members_id><team_members_names><![CDATA[ Doktorand: Stela Periš ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>18801</id><title_hr><![CDATA[Arheologija doline rijeke Kupe / Kolpe u kasno brončano i željezno doba]]></title_hr><title_en><![CDATA[Archaeology of the Kupa / Kolpa River Valley in the Late Bronze and Iron Ages]]></title_en><user_id>6690</user_id><user_firstLast_name>Ivan Drnić</user_firstLast_name><svouser_id>871099</svouser_id><svouser_firstLast_name>Lucija Grahek</svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-5244</code><acronim><![CDATA[ArchKRiver]]></acronim><duration>08.12.2025 - 07.12.2028</duration><status>U tijeku</status><financ_value>109.000,00 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Arheologija, </scie_field_hr><scie_field_en>Archeology, </scie_field_en><institution_hr><![CDATA[Arheološki muzej u Zagrebu]]></institution_hr><institution_en><![CDATA[Archeological Museum in Zagreb]]></institution_en><team_members_id>866672, 3646, 865364, 865399, 865379, 19692, 865377, </team_members_id><team_members_names><![CDATA[Zoran Čučković, Daria Ložnjak Dizdar, Ana Đukić, PROKOPIOS KONSTANTINOS TRIMMIS, Miroslav Razum, Kelly Reed, Emily Zavodny Zavodny, ]]></team_members_names><keywords_hr><![CDATA[Pokuplje, rijeka Kupa, arheologija, kasno brončano doba, željezno doba, naselja, nekropole, materijalna kultura]]></keywords_hr><keywords_en><![CDATA[Kupa River Valley, Kupa River, archaeology, Late Bronze Age, Iron Age, settlements, cemeteries, material culture]]></keywords_en><summary_hr><![CDATA[Specifičan položaj Pokuplja, smještenog na razmeđu triju geografskih i kulturnih regija - jugoistočnih Alpa, južne Panonije i zapadnog Balkana, učinio ga je važnom komponentom u komunikacijskoj mreži kasnog brončanog i željeznog doba, što se prepoznaje i u arheološkoj ostavštini. To je razdoblje u kojem će, u okviru projekta, biti razmatran povijesni razvoj pokupskih zajednica, a može se podijeliti u tri faze: kasno brončano doba u kontekstu kompleksa kulture polja sa žarama te starije i mlađe željezno doba s halštatskom i latenskom materijalnom kulturom kao dominantnim kulturnim fenomenima koji su obilježili srednjoeuropski prostor u razdoblju od 8. do 1. st. pr. Kr. U hrvatskom dijelu Pokuplja fokus projekta biti će na četiri nalazišta čijim istraživanjem i analizom prikupljene građe, uzoraka te prostornih i arhivskih podataka će se ostvariti bolji uvid u razvoj pokupskih zajednica tijekom 1. tisućljeća pr. Kr. Kako bi se dobio cjelovit uvid u društveno-ekonomske procese i pogrebne rituale, odabrani su naseobinski lokaliteti i nekropole. U gornjem toku rijeke Kupe projekt će se fokusirati na groblje pod humcima u Dugoj Gori te na ravnu nekropolu (potencijalno i tumule) i naselje u Ozlju dok će u Donjem Pokuplju naglasak biti na naseljima u Gornjem Pokupju i Sisku. Prikupljeni podatci biti će uspoređeni s dostupnim podatcima za istovremena naselja i nekropole iz slovenskog Pokuplja. Definirana su tri osnovna cilja projekta: 1. Analiza naseobinske dinamike i gospodarske osnove kasnobrončanodobnih i željeznodobnih zajednica u hrvatskom dijelu Pokuplja na primjeru naselja u Sisku, Ozlju i Donjem Pokuplju 2. Analiza promjena pogrebnih običaja na prijelazu kasnog brončanog i starijeg željeznog doba te nastanak željeznodobni nekropola iz perspektive materijalne kulture 3. Provedba istraživačke prakse, komplementarnost rezultata i sinkrona interpretacija arheološke slike sliva rije]]></summary_hr><summary_en><![CDATA[The location of the Kupa River valley at the crossroads of three geographical and cultural regions – the Southeastern Alps, Southern Pannonia, and the Western Balkans - made this area an important part of the communication network of the Late Bronze (LBA) and Iron Ages (IA). This is the time frame in which the historical development of the communities in the Kupa River valley will be researched as part of the project. This development can be divided into three phases: LBA in the context of the Urnfield Culture, the Early and Late Iron Age with the Hallstatt and La Tene material culture as the dominant cultural phenomena that shaped Central Europe between the 8th and 1st c. BC. The project will focus on four sites whose research and analysis of collected material, samples, spatial and archival data will provide a better insight into the development of local communities during the 1st millennium BC. Both settlements and cemeteries will be selected in order to gain a full insight into socio-economic processes and burial rituals. In the upper reaches of the Kupa River, the project will focus on the tumulus cemetery in Duga Gora and the flat cemetery and settlement in Ozalj, while in Lower Kupa Valley the focus will be on the settlements in Gornje Pokupje and Sisak. The collected data will be compared with the available data from contemporaneous settlements and cemeteries in the Slovenian part of the Kupa Valley. Three main objectives of the project are defined: 1. Analysis of the settlement dynamics and the economic basis of LBA and Iron Age communities using settlement examples from the Croatian area (Ozalj, Gornje Pokupje, Sisak) 2. Examination of the changes in burial customs at the transition from the LBA to the EIA and the emergence of IA cemeteries from the perspective of material culture 3. Application of good research practises, complementarity of results and synchronous interpretation of the archaeological picture of the Kupa Valley during the LBA and IA.]]></summary_en></project><project>
<id>18809</id><title_hr><![CDATA[Next Generation AI Researchers for Air Quality - NextAIRE]]></title_hr><title_en><![CDATA[]]></title_en><user_id>25928</user_id><user_firstLast_name>Josip Balen</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-4761</code><acronim><![CDATA[]]></acronim><duration>26.11.2025 - 25.11.2031</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera Osijek, Fakultet elektrotehnike, računarstva i informacijskih tehnologija Osijek]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Electrical Engineering, Computer Science and Information Technology Osijek]]></institution_en><team_members_id>872915</team_members_id><team_members_names><![CDATA[ Doktorand: Mislav Ćaleta ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>18810</id><title_hr><![CDATA[SeEduOpsAI: Otvorena platforma za umjetnom inteligencijom podržano poučavanje programskog inženjerstva]]></title_hr><title_en><![CDATA[SeEduOpsAI: Open Platform for AI Enhanced Software Engineering Education]]></title_en><user_id>24249</user_id><user_firstLast_name>Zlatko Stapić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-4117</code><acronim><![CDATA[SeEduOpsAI]]></acronim><duration>31.01.2026 - 30.01.2029</duration><status>U tijeku</status><financ_value>116.311,00 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Informacijske znanosti, </scie_field_hr><scie_field_en>Information sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet organizacije i informatike]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Organization and Informatics]]></institution_en><team_members_id>861549, 6054, 870454, 870391, 12796, 13612, 870382, 866659, 26634, 12531, 891, 874041, </team_members_id><team_members_names><![CDATA[Dijana Peras, Dijana Plantak Vukovac, Marija Maček, Ruben Picek, Darko Andročec, Matija Novak, Matej Mihaljević, Lovro Posarić, Marko Mijač, Vjeran Strahonja, Markus Schatten, Dario Ljubas, ]]></team_members_names><keywords_hr><![CDATA[UI, Umjetna inteligencija, Poučavanje, Softversko inženjerstvo, Razvoj softvera]]></keywords_hr><keywords_en><![CDATA[AI, Artificial Intelligence, Education, Software Engineering, Software Development]]></keywords_en><summary_hr><![CDATA[Unatoč sve većoj prisutnosti tradicionalnih i AI alata u obrazovanju, njihova uloga u nastavi softverskog inženjerstva ostaje fragmentirana i nedostaje joj strukturirani pristup. Kako bi se osigurala čvrsta teorijska osnova, ovo istraživanje ima za cilj sustavno istražiti i klasificirati AI alate u obrazovanju softverskog inženjerstva i procesu razvoja softvera, identificirajući ključna područja u kojima AI može pružiti značajnu podršku i nadopuniti tradicionalne alate. Nadalje, razvijat će se metodološki okvir koji pruža strukturirane smjernice o tome kako se AI alati mogu najbolje integrirati u agilni proces razvoja softvera. Na temelju ovih rezultata, istraživanje će dizajnirati i razviti prototip otvorene, AI-podržane platforme koja omogućuje integraciju više AI i tradicionalnih alata u cjelovito rješenje. Ova platforma pružit će modularno okruženje koje znanstvenicima i nastavnicima omogućuje izradu prilagođenih rješenja za različite nastavne aktivnosti, od razvoja kurikuluma do evaluacije studentskih projekata. Primjenom umjetne inteligencije platforma će smanjiti kognitivno i vremensko opterećenje nastavnika, dok će istovremeno unaprijediti kvalitetu obrazovanja u softverskom inženjerstvu. Međutim, korištenje AI-a ne podrazumijeva potpunu automatizaciju zadataka. Umjesto toga, AI djeluje kao asistent/konsultant, dok nastavnik zadržava konačne odluke i prilagodbe. Osim integracije postojećih AI rješenja, ovo istraživanje će konceptualizirati, dizajnirati i prototipirati nove AI-alate, posebno prilagođene za rješavanje pojedinačnih izazova u poučavanju softverskog inženjerstva. Potencijalni fokus ovih alata mogao bi biti podrška učenju temeljenom na projektima (PBL) i automatizirana evaluacija studentskih radova. Konačno, kako bi se procijenio potencijal i učinkovitost predložene platforme i pojedinačnih AI alata, istraživanje će provesti empirijske studije kroz implementaciju AI-podržanih rješenja u stvarnim obrazovnim okruženjima softverskog inženjerstva.]]></summary_hr><summary_en><![CDATA[Despite the growing presence of both traditional and AI tools in education, their role in software engineering teaching remains fragmented and lacks a structured approach. To ensure a strong theoretical foundation, this research aims to systematically explore and classify AI tools in software engineering education and software development process, identifying key areas where AI can provide meaningful support and complement traditional tools. Furthermore, we will develop a methodological framework that provides structured guidelines on how AI tools can be best integrated into agile software development process. Based on these findings this research will design and develop a prototype of an open, AI-supported platform that enables integration of multiple AI tools and traditional tools into a comprehensive solution. This platform will provide a modular environment that allows scientists and teachers to create custom solutions for various teaching activities, from curriculum development to project evaluation. Through AI, this platform aims to reduce the cognitive and time burdens on teachers while enhancing the overall quality of software engineering education. However, employing AI does not mean full automation of tasks. Rather, AI here acts as an assistant/consultant, and it is up to a teacher to make final decisions and adaptations. In addition to integrating existing AI solutions, this research will conceptualize, design, and prototype new AI-supported tools specifically tailored to address individual challenges in software engineering education. The potential focus of these tools might be project-based learning support and automated assessment of student work. Finally, to assess the potential and effectiveness of the proposed platform and individual tools, this research will conduct empirical studies by implementing the proposed AI-supported solutions in real SE education settings.]]></summary_en></project><project>
<id>18812</id><title_hr><![CDATA[Tretman i upravljanje jakim korelacijama: od fundamentalnih modela do suvremenih materijala]]></title_hr><title_en><![CDATA[Taming and Governing Strong Correlations: From Fundamental Models to Contemporary Materials]]></title_en><user_id>25108</user_id><user_firstLast_name>Juraj Krsnik</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2025-02</proposal_call><code>UIP-2025-02-5952</code><acronim><![CDATA[TaNGo]]></acronim><duration>01.04.2026 - 31.03.2031</duration><status>U tijeku</status><financ_value>265.750,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut za fiziku]]></institution_hr><institution_en><![CDATA[Institute of Physics in Zagreb]]></institution_en><team_members_id>26143, 855985, </team_members_id><team_members_names><![CDATA[Dino Novko, Nina Girotto Erhardt, ]]></team_members_names><keywords_hr><![CDATA[jako korelirani sustavi, neperturbativni dijagramatski razvoj, modeliranje iz prvih principa, neadijabatski učinci, kolektivni fenomeni]]></keywords_hr><keywords_en><![CDATA[strongly correlated systems, non-perturbative diagrammatic expansion, ab initio modeling,  non-adiabatic effects, collective phenomena]]></keywords_en><summary_hr><![CDATA[Razumijevanje i kontrola složenog ponašanja naprednih suvremenih materijala ključni su za budući tehnološki i industrijski napredak. Ova složenost proizlazi prvenstveno iz zamršene međuigre jakih elektronskih korelacija i interakcija elektrona s kristalnom rešetkom, što teorijsko modeliranje takvih materijala čini iznimno izazovnim. Tijekom posljednjih godina ostvaren je značajan napredak u proučavanju nelokalnih učinaka jakih elektronskih korelacija, što je dovelo do metoda koje uspješno obuhvaćaju mnoge eksperimentalno opažene značajke u koreliranim materijalima. Međutim, s rastućim prepoznavanjem važnosti neadijabatskih učinaka, ovi pristupi ostaju nepotpuni jer ne uzimaju u obzir učinke elektron-fonon međudjelovanja. Nastavno na ova dostignuća, cilj ovog projekta je stoga uspostaviti dijagramatsku metodu koja na neperturbativan način obrađuje nelokalnu dinamičku međuigru između elektronskih korelacija i elektron-fonon međudjelovanja unutar istog stupnja aproksimacije. Dodatno, ta metoda integrirat će se s ab initio metodama kako bi se omogućilo realistično modeliranje materijala te uspostavile kvantitativne i kvalitativne veze s eksperimentalnim rezultatima. Poseban naglasak bit će stavljen na razumijevanje spektralnih svojstava, te kvazičestičnih i kolektivnih pobuđenja u jako koreliranim metalnim režimima, kao i na istraživanje mehanizama koji leže u osnovi formiranja valova gustoće naboja i supravodljivih nestabilnosti, s ciljem pružanja uvida koji bi mogli usmjeriti eksperimentalne napore prema postizanju viših kritičnih temperatura supravodljivosti.]]></summary_hr><summary_en><![CDATA[Understanding and controlling the complex behavior of advanced contemporary materials is key to future technological and industrial advancements. This complexity arises primarily from the intricate interplay between strong electron correlations and their interactions with the crystal lattice, making theoretical modeling of these materials highly challenging. In recent years, significant progress has been made in studying non-local strong electron correlation effects, leading to methods capable of capturing many features observed experimentally in correlated materials. However, as the importance of non-adiabatic effects becomes increasingly recognized, these approaches remain incomplete, as they do not account for electron-phonon interaction effects. Building on these developments, this project aims to establish a diagrammatic method that non-perturbatively treats the non-local dynamical interplay between electron correlations and electron-phonon interactions within the same level of approximation. Additionally, we seek to integrate this framework with ab initio methods to enable realistic material modeling and establish both quantitative and qualitative connections with experimental findings. A particular emphasis will be placed on understanding spectral properties, and quasiparticle and collective excitations in strongly correlated metallic regimes, as well as exploring the mechanisms underlying charge-density wave formation and superconducting instabilities, with a goal to provide insights that could guide experimental efforts toward achieving higher superconducting transition temperatures.]]></summary_en></project><project>
<id>18814</id><title_hr><![CDATA[Evolucija složenih magnetskih i polarnih uređenja iz jednostavnih 2D podstruktura u slojevitim hibridnim organsko-anorganskim halogenometalatima]]></title_hr><title_en><![CDATA[]]></title_en><user_id>634</user_id><user_firstLast_name>Mirta Rubčić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-4976</code><acronim><![CDATA[HOI2DEM]]></acronim><duration>20.03.2026 - 19.03.2032</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>874011</team_members_id><team_members_names><![CDATA[ Doktorand: Marko Bochniček ]]></team_members_names><keywords_hr><![CDATA[2D materijali, hibridna struktura, magnetsko uređenje, feroelektrici, magnetoelektrici, magnetotransport, foto- i opto-magnetizam, nered]]></keywords_hr><keywords_en><![CDATA[2D materials, hybrid structure, magnetic order, ferroelectrics, magnetoelectrics, magnetotransport, photo- and opto-magnetism, disorder]]></keywords_en><summary_hr><![CDATA[Sustavi u kojima se javljaju magnetska i polarna uređenja od velikog su zanimanja u fizici i kemiji kondenzirane materije, a dvodimenzionalni (2D) materijali postali su strateški za područja elektronike/spintronike, fotonike, energetike, biomedicine. U okviru projekta razvijat će se novi hibridni organsko-anorganski halogenometalati(II), HOAH, slojevitih struktura koji bi se odlikovali složenim magnetskim i polarnim uređenjima, s ciljem ostvarenja multiferoičnosti, te prema mogućnostima magneto-električnog vezanja. Razvoj će teći uvođenjem funkcionalnih kiralnih i/ili asimetričnih organskih kationa te dopiranjem/supstitucijom pojedinih strukturnih podjedinica u HOAH sustavima. Polarna uređenja kao i lokalna simetrija strukturnih podjedinica utvrdit će se difrakcijskim tehnikama i spektroskopskim analizama te električnim mjerenjima. Eksperimentalno će se rigorozno istražiti magnetska uređenja ili nered, kako globalno pomoću magnetizacije i izmjenične susceptibilnosti, tako i lokalno pomoću elektronske i nuklearne spinske te kvadrupolne rezonancije. Potkrjepa kvantno-mehaničkim ab-initio računima upotpunit će saznanja o električnoj polarizaciji i magnetskim međudjelovanjima. Za odabrane faze HOAH sustava istražit će se strukturni i magnetski odziv na vanjske parametre (električno polje, tlak, svjetlost) što će pružiti saznanja o uspostavi egzotičnih stanja te dati dodatni uvid u mehanizme superizmjene. Provest će se i magneto-transportna te optička istraživanja radi širenja puteva prema primjeni u opto-magneto-elektronici. Odabrani HOAH priredit će se i karakterizirati u obliku tankih filmova, jer je njihov razvoj nužan radi ugradnje u nano-uređaje. Razvit će se element temeljen na spoju tankog filma HOAH i vodljivog polimera, gdje će se naponskim vratima nastojati izazvati promjenu magnetskog, električnog i/ili optičkog stanja. Istraživanje u ovako multidisciplinarnom timu rasvijetlit će neka pitanja o HOAH kao (kvazi)2D materijalima.]]></summary_hr><summary_en><![CDATA[Systems in which magnetic and polar orders occur are of great interest in condensed matter physics and chemistry, and two-dimensional (2D) materials have become strategic for the fields of electronics/spintronics, photonics, energy, biomedicine. Within the project, new hybrid organic-inorganic halometallates(II), HOAH, will be developed, with layered structures that would have complex magnetic and polar orders, with the aim of achieving multiferroicity, and possibly magnetoelectric coupling. Development will proceed with the implementation of functional chiral and/or asymmetric organic cations and doping/substitution of individual structural scaffolds in HOAH systems. Polar order as well as local symmetry of structural units will be determined by diffraction and spectroscopic techniques, and electrical measurements. Magnetic properties will be rigorously investigated experimentally, both with study of bulk magnetization and AC susceptibility, and locally, using electron and nuclear spin and quadrupole resonance.  Ab-initio calculations will complement the experimental results. For selected HOAH phases, the structural and magnetic response to external parameters (electric field, pressure, light) will be investigated, which will provide knowledge about the formation of exotic states and additional insight into super-exchange mechanisms. Magneto-transport and optical research will be conducted in order to pave the way towards application in opto-magneto-electronics. The selected HOAHs will be prepared and characterized in the thin film form, since their development is crucial for the integration into nano-devices. A device based on the junction of a thin film of HOAH with a functional substrate will be developed, where a voltage gate would be used to manipulate the magnetic, electrical and/or optical state. Research in such a multidisciplinary team will elucidate some aspects about HOAH as (quasi)2D materials.]]></summary_en></project><project>
<id>18817</id><title_hr><![CDATA[Radionička proizvodnja i uvoz u 8. i 9. stoljeću na području sjeverne Dalmacije]]></title_hr><title_en><![CDATA[]]></title_en><user_id>7828</user_id><user_firstLast_name>Mirja Jarak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-1560</code><acronim><![CDATA[Medievalworkshops]]></acronim><duration>12.01.2026 - 11.01.2032</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Arheologija, </scie_field_hr><scie_field_en>Archeology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>873047</team_members_id><team_members_names><![CDATA[ Doktorand: Ivo Ćevid ]]></team_members_names><keywords_hr><![CDATA[sjeverna Dalmacija, 8. i 9. stoljeće, radionice, keramika, metalni, koštani i stakleni nalazi, tekstil, kameni spomenici, arheometrija]]></keywords_hr><keywords_en><![CDATA[Northern Dalmatia, 8th and 9th century, workshops, ceramics, metal, bone and glass artefacts, textile, stone monuments, archaeometry]]></keywords_en><summary_hr><![CDATA[Projektni  prijedlog &#39;&#39;Radionička proizvodnja i uvoz u 8. i 9. stoljeću na području sjeverne Dalmacije&#39;&#39; uključuje istraživanje različitih tipova arheoloških nalaza koje povezuje osnovno istraživačko pitanje o mogućnostima preciznog utvrđivanja radioničkog porijekla. To podrazumijeva detaljnije spoznaje o regionalnim dalmatinskim ranosrednjovjekovnim radionicama, kao i sigurnije atribucije pojedinih nalaza određenim stranim radionicama.U projektu će se prikupljati podaci o elementnom sastavu, tehnologiji i tragovima izrade metalnih, keramičkih, kamenih, staklenih, koštanih i tekstilnih nalaza. Osim primjene klasičnog vizualnog pregleda i korištenja fotoaparata, podaci će se prikupljati pomoću raznih uređaja kojima će upravljati članovi projektnog tima i zaposlenici laboratorija vanjskih institucija, što jamči kvalitetu provedenih analiza i interpretacija.Spomenute analize omogućit će cjelovite spoznaje o nalazima i otkriti razlike između radionica koje su djelovale ili bile povezane s područjem sjeverne Dalmacije u 8. i 9. stoljeću. Predloženo istraživanje treba rezultirati znanjem o porijeklu predmeta i detaljima radioničkih obilježja proizvodnje, što je još nepoznato. Projektni rezultati trebali bi predstavljati osnovu za šire kontekstualne interpretacije ranosrednjovjekovne arheološke baštine s područja sjeverne Dalmacije, njezino bolje razumijevanje i vrednovanje.]]></summary_hr><summary_en><![CDATA[The project proposal “The 8th and 9th century workshop production and imports at the territory of Northern Dalmatia“ includes research into different types of archaeological findings connected by the basic research question on the possibility of precise determination of artefacts workshop origin. That implies a detailed knowledge of the regional Dalmatian early medieval workshops and secure atribution of particular findings to certain foreign workshops.In the project data on the elemental composition, technology and traces of production of metal, ceramic, stone, glass, bone and textile artefacts will be collected. In addition to visual inspection and the use of a digital camera, data will be collected using various devices managed by team members and experts from the laboratories of external institutions, which guarantees the quality of the performed analyses and interpretations.The mentioned analyses will provide a comprehensive knowledge on objects in question and reveal the differences in production due to different workshops that operated or were associated with the region of northern Dalmatia in the 8th and 9th century. The proposed research should  provide a reliable knowledge on the origin of the finds and details of  work of individual workshops, that are currently unknown.The results  should serve as a basis for broader contextual interpretations of the early medieval archaeological heritage from the northern Dalmatia territory and its better understanding and evaluation.]]></summary_en></project><project>
<id>18818</id><title_hr><![CDATA[Radiološki utjecaj teških nesreća u nuklearnim elektranama na okoliš i lokalno stanovništvo]]></title_hr><title_en><![CDATA[]]></title_en><user_id>29692</user_id><user_firstLast_name>Siniša Šadek</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-6131</code><acronim><![CDATA[RUNOLIST]]></acronim><duration>12.11.2025 - 11.11.2025</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>868537</team_members_id><team_members_names><![CDATA[ Doktorand: Petra Strmečki ]]></team_members_names><keywords_hr><![CDATA[nuklearna elektrana, teške nesreće, oštećenje jezgre, radioaktivni ispust, doza zračenja, kvantifikacija neodređenosti]]></keywords_hr><keywords_en><![CDATA[nuclear power plant, severe accidents, core damage, radioactive release, radiation dose, uncertainty quantification]]></keywords_en><summary_hr><![CDATA[Nesreća u nuklearnoj elektrani Fukushima potaknula je mnoge elektrane da provedu modifikacije za unapređenje sigurnosti, kao i da se unaprijede programi pripravnosti za slučaj teške nesreće. Iako u Hrvatskoj nema nuklearnih elektrana, ova je problematika itekako važna s obzirom da se u našoj neposrednoj okolici nalazi pet nuklearnih elektrana, jedna u Sloveniji, a četiri u Mađarskoj. Cilj projekta je procijeniti realno stanje ugroženosti populacije u Hrvatskoj i izračunati primljene doze za slučaj nesreće u obližnjoj elektrani. U početnoj fazi će se napraviti pregled svih mogućih nesreća s teških posljedicama i selektirati najteži kvarovi korištenjem determinističkog i probabilističkog pristupa. Nakon toga će se pripremiti model jezgre reaktora za ocjenu inventara radioaktivnog materijala. Integralna analiza propagacije nesreće u reaktorskoj posudi, primarnom i sekundarnom krugu elektrane, te u reaktorskoj zgradi obuhvatit će sve puteve ispusta i transporta radionuklida unutar podsustava elektrane. Rezultat će biti podatak o mjestu i iznosu radioaktivnog ispusta iz nuklearne elektrane u okoliš. Model atmosferske disperzije koristit će realne meteorološke podatke za procjenu koncentracija radionuklida na širem geografskom području. Konačno će se ti podaci iskoristiti za određivanje efektivne ekvivalentne doze zračenja koju primi ugroženo stanovništvo. Kako se u svim fazama izračuna pojavljuju veće ili manje neodređenosti vezane uz neprecizne početne i rubne uvjete, napravit će se računalni alat koji će pomoći u kvantifikaciji neodređenosti, određivanju mjera važnosti i procjeni kritičnih parametara za određivanje veličine radioaktivnog ispusta i utjecaja na stanovništvo.]]></summary_hr><summary_en><![CDATA[The accident at the Fukushima nuclear power plant prompted many power plants to implement safety-enhancing modifications, as well as to improve their major accident preparedness programs. Although there are no nuclear power plants in Croatia, this issue is very important considering that there are five nuclear power plants in our immediate vicinity, one in Slovenia and four in Hungary. The aim of the project is to assess the real state of threat to the population in Croatia and calculate the doses received in case of an accident at a nearby power plant. In the initial phase, an overview of all possible accidents with severe consequences will be made and the most severe failures will be selected using a deterministic and probabilistic approach. After that, a model of the reactor core will be prepared for the evaluation of the radioactive material inventory. An integral analysis of the propagation of the accident in the reactor vessel, the primary and secondary circuit of the power plant, and in the reactor building will cover all the paths of release and transport of radionuclides within the subsystem of the power plant. The result will be information on the location and amount of radioactive discharge from the nuclear power plant into the environment. The atmospheric dispersion model will use realistic meteorological data to estimate radionuclide concentrations over a wider geographic area. Finally, these data will be used to determine the effective equivalent dose of radiation received by the vulnerable population. As greater or lesser uncertainties related to imprecise initial and boundary conditions appear in all phases of the calculation, a computer tool will be created that will help in the quantification of uncertainties, determination of measures of importance and assessment of critical parameters for determining the size of the radioactive release and impact on the population.]]></summary_en></project><project>
<id>18820</id><title_hr><![CDATA[Civil Protection Plan Digitalization through Internet of Things Decision Support System based Platform (DIGITAL PLAN)  ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>7605</user_id><user_firstLast_name>Petar Šolić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-4587</code><acronim><![CDATA[]]></acronim><duration>07.01.2026 - 06.01.2032</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Fakultet elektrotehnike, strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Electrical Engineering, Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>873000</team_members_id><team_members_names><![CDATA[ Doktorand: Ana Terzić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>18821</id><title_hr><![CDATA[Nova generacija dentalnih kompozita: Integracija cinkom obogaćenih mezoporoznih bioaktivnih nanosfera za poboljšanje antibakterijskih svojstava]]></title_hr><title_en><![CDATA[]]></title_en><user_id>26045</user_id><user_firstLast_name>Danijela Marović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-1229</code><acronim><![CDATA[MEZONANO]]></acronim><duration>16.01.2026 - 15.01.2032</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Dentalna medicina, </scie_field_hr><scie_field_en>Dental medicine, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Stomatološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Dentistry]]></institution_en><team_members_id>873066</team_members_id><team_members_names><![CDATA[ Doktorand: Marija Kelić ]]></team_members_names><keywords_hr><![CDATA[bioaktivno staklo, kompoziti, stomatološki, cink, fluor, mezoporozne čestice]]></keywords_hr><keywords_en><![CDATA[bioactive glass, composites, dental, zinc, fluorine, mesoporous particles]]></keywords_en><summary_hr><![CDATA[Konvencionalnim dentalnim kompozitima nedostaju svojstva koja bi mogla spriječiti sekundarni karijes, kao što su svojstva remineralizacije, neutralizacije kiseline i antimikrobna svojstva. Kako bi se riješio ovaj problem, predložena je ugradnja bioaktivnog stakla u dentalne kompozite, jer ono može otpuštati ione koji potiču remineralizaciju zubne strukture. Cilj projekta je razviti funkcionalne dentalne kompozitne materijale kako bi se spriječio nastanak sekundarnog karijesa.Mezoporozne bioaktivne staklene nanosfere s cinkovim oksidom (Zn-MBGN) imaju antibakterijska svojstva i otpuštaju ione kalcija koji su neophodni za ponovnu izgradnju kristala apatita. U okviru projekta sintetizirat će se Zn-MBGN čestice s rastućim sadržajem cinkovog oksida (0, 1 i 5%) te dodati u eksperimentalne kompozite u rastućim udjelima od 1-7%, zadržavajući identičnu smolastu matricu i inertna punila, tako producirajući 12 eksperimentalnih kompozita. Sveobuhvatno istraživanje u 27 različitih testova pružit će informacije o njihovim brojnim fizičkim, kemijskim, mehaničkim i biološkim svojstvima te njihovoj učinkovitosti na zubima.Osim Zn-MBGN kompozita, u ovom projektu će se nastaviti istraživanje kompozitnih materijala s fluoridom obogaćenim bioaktivnim staklom niskog udjela natrija (F-BG), koje je uspješno razvijeno u prethodnom projektu.Razvoj dentalnih kompozitnih materijala koji sadrže čestice bioaktivnog stakla ima potencijal za poboljšanje dugoročnog uspjeha zubnih restauracija unaprjeđenjem antibakterijskih svojstava i promicanjem remineralizacije zubne strukture, uz zadržavanje stabilnih mehaničkih svojstava. Ovaj projektni prijedlog ocrtava sveobuhvatan pristup za razvoj i procjenu takvog kompozitnog materijala koji bi mogao imati značajan klinički učinak u području restaurativne dentalne medicine.]]></summary_hr><summary_en><![CDATA[Conventional resin-based composites lack properties that could prevent secondary caries, such as remineralising, acid-neutralising and antimicrobial properties. To solve this problem, the incorporation of bioactive glass into dental composites has been proposed, as it can release ions that promote remineralisation of the tooth structure. The aim of the project is to develop functional composite materials for dental restorations to prevent the occurrence of secondary caries.Mesoporous bioactive glass nanospheres with zinc oxide (Zn-MBGN) have antibacterial properties and release calcium ions, which are necessary for the reconstruction of apatite crystals. In the project, Zn-MBGN particles with increasing zinc oxide content (0, 1 and 5%) will be synthesised and incorporated in increasing proportions of 1-7% into experimental composites with identical resin matrix and inert fillers to produce 12 experimental composite materials. A comprehensive investigation in 27 different tests will provide information on numerous physical, chemical, mechanical and biological properties and their effectiveness on teeth in vitro.In addition, research into composite materials with fluoride-doped low sodium bioactive glass (F-BG), which was successfully developed in the previous project, will be continued in this project.The development of dental composite materials containing bioactive glass particles has the potential to improve the long-term success of dental restorations by enhancing antibacterial properties and promoting remineralisation of the tooth structure while maintaining stable mechanical properties. This project proposal outlines a comprehensive approach for the development and evaluation of such a composite material that could have significant clinical impact in the field of restorative dental medicine. ]]></summary_en></project><project>
<id>18825</id><title_hr><![CDATA[Koordinirani sustavi i tržišta vodika i električne energije]]></title_hr><title_en><![CDATA[]]></title_en><user_id>7162</user_id><user_firstLast_name>Hrvoje Pandžić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-6819</code><acronim><![CDATA[CHESS]]></acronim><duration>03.11.2025 - 02.11.2031</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>872912</team_members_id><team_members_names><![CDATA[ Doktorand: Ante Galić ]]></team_members_names><keywords_hr><![CDATA[spremnici energije, baterijski spremnici energije, vodik, elektrolizator, gorivni članak, tokovi snaga, energetska tržišta]]></keywords_hr><keywords_en><![CDATA[energy storage, battery energy storage, hydrogen, electrolyzer, fuel cell, power flow, energy markets]]></keywords_en><summary_hr><![CDATA[Golemi rast varijabilnih obnovljivih izvora energije (vjetroelektrana i solarnih elektrana) zahtijeva integraciju spremnika energije u elektroenergetski sustav. Projekt je usmjeren na pružanje fleksibilnosti korištenjem dvije tehnologije pohrane energije, baterijskih sustava i vodika. Prvi cilj projekta je razviti točne modele baterijskih spremnika energije temeljenih na laboratorijskim mjerenjima koja uzimaju u obzir specifičnosti litij-ionske tehnologije poput varijabilne učinkovitosti i mogućnosti punjenja te degradacije. Drugi cilj je razviti točne modele elektrolizatora i gorivnih članaka. Modeli će biti također razvijeni na temelju laboratorijskih mjerenja i procedura i uzimat će u obzir promjenjivu učinkovitost i učinke čestih promjena radne točke, primjerice prilikom pružanja brzih frekvencijskih usluga operatoru sustava, na degradaciju. Razvijeni modeli će se potom koristiti u trećem cilju u svrhu formuliranja optimalnog pogonskog modela fleksibilnog postrojenja (koji se sastoji od obnovljivih izvora energije i spremnika energije) koji sudjeluje u tržištima električne energije i vodika uvjetima nesigurnosti. Pogonski model fleksibilnog postrojenja nadogradit će se i formulirati optimalni investicijski model za takvo postrojenje koje sudjeluje na više energetskih tržišta. Posljednji cilj projekta je razviti brze modele optimalnih tokova snaga i vodika. Ti modeli će se koristiti za simulaciju čišćenja tržišta električne energije i vodika u modelu fleksibilnog postrojenja čiji je kapacitet dovoljno velik da ima utjecaj na tržišne cijene električne energije i vodika. Rezultirajući dvorazinski modeli bit će učinkovito riješeni korištenjem neuronskih mreža. Rezultati projekta imat će važan utjecaj na upravljačke algoritme baterija, elektrolizatora i gorivnih članaka te će povećati tržišni profit kroz pružanje različitih usluga. Laboratorijska mjerenja su ključna za potvrđivanje razvijenih algoritama i osiguranje fizičke izvedivosti dobivenih rasporeda. ]]></summary_hr><summary_en><![CDATA[The high rate of growth of variable renewable sources, i.e. solar and wind, calls for integration of energy storage in power systems. This project focuses on flexibility provision of two storage technologies, battery storage and hydrogen. The first project objective is to develop accurate models for battery storage based on laboratory measurements, taking into consideration the specifics of the lithium-ion battery technology such as variable efficiency, variable charging rates, and degradation.  The second objective is to develop accurate models of electrolyzers and fuel cells. Also based on laboratory procedures and measurement, considering the variable efficiency and effects of operating point changes, e.g. when providing fast frequency response to the system operator, on degradation. The developed models will be then used in the third objective to formulate the optimal flexible facility (consisting of renewable sources and energy storage) bidding model under uncertainty in the power and hydrogen markets. The flexible facility operational models will be expanded to derive the optimal investment model for a flexible facility taking part in various markets. The final objective will be to develop fast and efficient optimal power flow and hydrogen flow models. These models will be used to simulate electricity and hydrogen market clearing for price-making flexible facilities whose bids affect market prices. The resulting bilevel models will be effectively solved using the neural network approach. The project results will have a strong impact on the battery, electrolyzer and fuel cell control algorithms, improving the market profit from different revenue streams. The laboratory measurements are crucial for validating the developed algorithms and ensure feasibility of the obtained schedules in reality. ]]></summary_en></project><project>
<id>18826</id><title_hr><![CDATA[Potpuno održivi elementi drvenih konstrukcija bez ljepila i metalnih spajala]]></title_hr><title_en><![CDATA[]]></title_en><user_id>19348</user_id><user_firstLast_name>Vlatka Rajčić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-1758</code><acronim><![CDATA[ECO-WOOD Structures]]></acronim><duration>01.12.2025 - 30.11.2031</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Građevinarstvo, </scie_field_hr><scie_field_en>Civil engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Građevinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Civil Engineering]]></institution_en><team_members_id>873013</team_members_id><team_members_names><![CDATA[ Doktorand: Jelena Galić ]]></team_members_names><keywords_hr><![CDATA[održiva gradnja, drvene konstrukcije, lamelirano drvo, križno-lamelirano drvo, densificirani trnovi, varenje drvenih trnova]]></keywords_hr><keywords_en><![CDATA[sustainable building, timber structures, laminated timber, cross-laminated timber, densified dowels, timber dowels welding ]]></keywords_en><summary_hr><![CDATA[Korištenje drva kao materijala u građevinarstvu jedna je od temeljnih strategija održivog razvoja. Osim što dugoročno skladište apsorbirani ugljikov dioksid, drvene konstrukcije imaju prednost brze i jednostavne predgotovljene gradnje, ponovne uporabe i potpunog recikliranja. Danas, lamelirani drveni elementi zasnovani su na lijepljenju ili korištenju metalnih spajala. Ljepila, kao i metal, ograničavaju trajnost i požarnu otpornost drva, onemogućavaju potpuno rastavljanje i recikliranje konstrukcije te ostavljaju snažan ugljični otisak. Razvoj drvne tehnologije rezultirao je novim, potpuno održivih tehnikama lameliranja dasaka. Za razliku od standardiziranih metoda, uporaba trnova od densificiranog drva, kao i zavarenih trnova od tvrdog drva, omogućava proizvodnju visokokvalitetnih elemenata, a da se pri tom ne koriste adhezivi ili metalna spajala. Kod densifikacije drva, osnovni materijal postiže bolja materijalna svojstva primjenom privremenog povećanja tlaka, čime se trajno zgušnjava praznina između staničnog materijala. Kod zavarenih drvenih trnova, visokofrekventno trljanje dviju površina uzrokuju trenje i toplinu koji omekšavaju, a zatim vezuju lignin, mehanički spajajući stanični materijal. Ove tehnike imaju potencijal za primjenu ne samo na lamelirane linijske, već i na križno-lamelirane plošne element, koji su ključni za izgradnju više-etažnih građevina. Suradnjom domaćih i međunarodnih istraživača kroz laboratorijska ispitivanja, numeričke analize i procjenu životnog ciklusa, istražile bi se karakteristike drvenih elemenata lameliranih na potpuno ekološki način. Konačni rezultat bili bi točno definirani principi oblikovanja, kao i matematički izrazi za proračun mehaničke otpornosti i stabilnosti te uporabivosti ovakvog tipa elemenata. Ujedno, istraživanje bi rezultiralo osnovama za proizvodnju potpuno održivih građevinskih elemenata čije daljnje usavršavanje i proizvodnju, zbog prihvatljivih cijena ulaganja, u znatnoj mjeri mogu ostvariti i domaće tvrtke.]]></summary_hr><summary_en><![CDATA[The use of wood as building material is one of the fundamental strategies of sustainable development. In addition to long-term storage of absorbed carbon dioxide, timber structures have an advantage of fast and simple prefabricated construction, reuse and complete recycling. Today, laminated timber elements are based on gluing and use of metal fasteners. Adhesives, as well as metal, limit the durability and fire resistance, make it impossible to completely disassemble and recycle the structure, and leave a strong carbon footprint. Development of wood technology resulted in new, fully sustainable techniques for laminating boards. In contrast to standardized methods, the use of dowels made of densified wood, as well as hardwood welded dowels, enables the production of high-quality elements without using adhesives or metal fasteners. In wood densification, the base material achieves better properties by applying a temporary increase in pressure, which permanently densifies the void between the cellulars. In welded wooden dowels, high frequency rubbing of the two surfaces causes friction and heat that soften and then bond the lignin, mechanically joining the cellular material. These techniques have the potential to be applied not only to linear laminated girders or columns, but also to cross-laminated plate elements, which are crucial for construction of multi-storey buildings. Cooperation of domestic and international researchers through laboratory tests, numerical and life cycle analyses, the characteristics of timber elements laminated in completely ecological way would be investigated. The result would be precisely defined assembly principles, as well as mathematical expressions for design of this type of elements. At the same time, the research would result in the production basis of fully sustainable construction elements, which further improvement and production, due to acceptable investment prices, can be achieved to a considerable extent by domestic companies.]]></summary_en></project><project>
<id>18828</id><title_hr><![CDATA[Gljive hidrološki aktivnih špiljskih ekosustava Dinarida i njihov bioaktivni potencijal]]></title_hr><title_en><![CDATA[]]></title_en><user_id>13114</user_id><user_firstLast_name>Ivana Kušan</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-4207</code><acronim><![CDATA[FunCavBioA]]></acronim><duration>23.12.2025 - 22.10.2030</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>873025</team_members_id><team_members_names><![CDATA[ Doktorand: Ivana Saraga ]]></team_members_names><keywords_hr><![CDATA[mikodiverzitet, bioprospekcija, bioaktivne tvari, krško podzemlje, integrativna taksonomija, bioindikatori, voda u kršu, klimatske promjene]]></keywords_hr><keywords_en><![CDATA[mycodiversity, bioprospecting, bioactive compounds, karst underground, integrative taxonomy, bioindicators, water in karst, climatic change]]></keywords_en><summary_hr><![CDATA[Gljive su nezamjenjivi simbionti, stabilizatori ekološke ravnoteže i razlagači koji omogućuju kruženje tvari i energije. Bioraznolikost gljiva mjeri se u milijunima vrsta, no znanosti je poznato manje od 10% njihovog ukupnog broja. Dinarski krš je u smislu bioraznolikosti i hidrologije jedno od najznačajnijih krških područja svijeta, a gljive su u njemu nedovoljno istražene. Ovaj prostor iznimno je važan za očuvanje zaliha pitke vode, na čiju kvalitetu značajno utječe i njegov živi svijet. Trajni mrak, visoka vlažnost zraka i stabilna temperatura čine špilje prirodnim laboratorijima u kojima su gljive podvrgnute selekcijskim pritiscima što rezultira raznolikim adaptacijskim mehanizmima. Zbog toga očekujemo da ove gljive imaju izniman bioindikatorski i bioprospekcijski potencijal. Ovo je prvo sustavno istraživanje gljiva u dinarskom krškom podzemlju koje će uključiti interdisciplinarna istraživanja u obuhvatu: špiljski ekosustav – ukupna bioraznolikost gljiva – gljivlji organizmi – bioindikatori – profiliranje sekundarnih metabolita – biološki potencijal. Ciljevi projekta su istražiti biološku raznolikost špiljskih gljiva te utvrditi njihove ekološke i biogeografske značajke. Kod odabranih vrsta gljiva testirat će se i biološka aktivnost njihovih ekstrakata, provesti profiliranje sekundarnih metabolita i kemijska karakterizacija potencijalno bioaktivnih tvari. Istraživanja će se provesti u hidrološki aktivnim špiljskim sustavima Hrvatske i Bosne i Hercegovine, u mediteranskoj, alpskoj i kontinentalnoj ekoregiji, na pet različitih geotektonskih jedinica i svim ekološkim nišama. Očekivani rezultati bitno će doprinijeti poznavanju bioraznolikosti i ekoloških odnosa gljiva u krškom podzemlju te pružiti uvid u njihov bioaktivni potencijal s ciljem davanja smjernica budućim biotehnološkim istraživanjima.]]></summary_hr><summary_en><![CDATA[Fungi are irreplaceable symbionts, drivers of ecological balance, and decomposers that enable the cycling of matter and energy. The biodiversity of fungi is measured in millions of species, but less than 10% of their total number is known to science. The Dinaric Karst is one of the most important karst regions in the world in terms of biodiversity and hydrology, where fungi are poorly studied. This area is particularly important for the preservation of drinking water resources, the quality of which is significantly influenced by the organisms living there. Permanent darkness, high humidity and steady temperature make caves natural laboratories in which fungi are exposed to selection pressures that leads to diverse adaptation mechanisms. Therefore, we assume that these fungi have exceptional bioindicator and bioprospecting potential. This is the first systematic study of fungi in the Dinaric Karst involving interdisciplinary research in the scope: cave ecosystem - total fungal biodiversity - fungal organisms - bioindicators - secondary metabolite profiling - biological potential. The objectives of the project are to explore the biodiversity of cave fungi and to ascertain their ecological and biogeographical characteristics. In addition, the biological activity of their extracts will be tested for the selected fungal species, a profile of secondary metabolites will be established, and a chemical characterisation of the potentially bioactive compounds will be carried out. The research will be conducted in hydrologically active cave systems in Croatia and Bosnia and Herzegovina, in Mediterranean, Alpine and Continental ecoregions, in five different geo-tectonic units and all ecological niches. The expected results will make an important contribution to the knowledge of biodiversity and ecological relationships in the karst underground and give insight into the bioactive potential of cave fungi, with the aim of providing guidelines for future biotechnological research.]]></summary_en></project><project>
<id>18835</id><title_hr><![CDATA[Istraživanje kvantnih fluktuacija u sustavima hladnih atoma]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4442</user_id><user_firstLast_name>Petar Stipanović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-3299</code><acronim><![CDATA[EQUAFLU]]></acronim><duration>24.11.2025 - 23.11.2031</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Science]]></institution_en><team_members_id>872977</team_members_id><team_members_names><![CDATA[ Doktorand: Marko Korda ]]></team_members_names><keywords_hr><![CDATA[ultrarijetke kapljice, kvantne fluktuacije, Bose-Einstenov kondenzat, kvantni Monte Carlo, teorija funkcionala gustoće]]></keywords_hr><keywords_en><![CDATA[ultradilute droplets, quantum fluctuations, Bose-Einstein condesate, quantum Monte Carlo, density functional theory]]></keywords_en><summary_hr><![CDATA[Ultra-rijetke kapljice bozonskih mješavina koje su nedavno otkrivene u sustavima hladnih atoma svoju stabilnost duguju kvantnim fluktuacijama. U prethodnim smo istraživanjima pokazali da mnogočestični pristup iz prvih principa, uz kombinaciju kvantnih Monte Carlo simulacija i teorije funkcionala gustoće omogućava pouzdano predviđanje njihovih svojstava. U ovom projektu želimo otići korak u razvoju metoda kvantnog Monte Carla kako bismo istražili efekte kvantnih fluktuacija u tri posebno zanimljiva sustava. Prvo, za komprimirane kapljice bozonskih mješavina želimo odrediti pobuđenja, proučiti vrtloge i ispitati ponašanje primjesa. Drugo, želimo ispitati statičko i dinamičko ponašanje hladnih atoma u periodičnim i kvazi-periodičnim potencijalima, s naglaskom na ultra-rijetke kapljice. Kvantne fluktuacije u takvim sustavima tek su se počele ispitivati, a očekujemo da bi mogle dovesti i do novih faza. Planiramo proučiti dinamiku nakon quenchinga potencijala rešetke ili interakcije kako bismo razumjeli ulogu interakcija u kvazi-periodičnim sustavima daleko od ravnoteže. Neravnotežna mnogočestična fizika postala je fokus interesa mnogih eksperimenata s kvantnim plinovima, a simulacije vremenski ovisnog Varijacijskog Monte Carla idealno su prilagođene za njihovu simulaciju.  Za odabrane sustave odredit ćemo promjene faznog dijagrama s temperaturom, što će osim zajednici ultrahladnih atoma vrijedan uvid dati i zajednici koja proučava adsorpciju kvantnih fluida na supstratima. Kao treće, metodom difuzijskog Monte Carla proučit ćemo bozonsko-fermionsku mješavinu. Variranjem interakcija nadamo se pronaći i karakterizirati režim ultra-rijetke tekućine. Očekujemo da će naša istraživanja biti korisna za vođenje i interpretiranje budućih eksperimenata.]]></summary_hr><summary_en><![CDATA[Ultra-dilute droplets of Bose-Bose mixtures that have been recently discovered in systems of cold atoms owe their stability to quantum fluctuations.  In our previous research we have shown that first principle many-body approach, combining quantum Monte Carlo simulations and density functional theory enables reliable prediction of their properties. In this project we want to take a step forward in developing quantum Monte Carlo methods with the goal of exploring the effects of quantum fluctuations in three particularly interesting systems. First, for compressed droplets of Bose-Bose mixtures we want to determine excitations, study vortices and investigate the behaviour of impurities.  Second, we want to explore static and dynamic behaviour of cold atoms in periodic and quasi-periodic potentials, with emphasis on ultradilute droplets. Quantum fluctuations in these systems are only starting to be explored, and we expect new phases to be uncovered. We plan also to study dynamics after quenching lattice potential or interaction to understand the role of interactions in quasi-periodic systems far from equilibrium. Non-equilibrium many-body physics has become the focus of many quantum gas experiments and  tVMC is ideally suited to simulate them. For chosen systems we will determine the changes of phase diagram with temperature, which will besides the community of ultracold atoms give valuable insight to the community studying adsorption of quantum fluids on substrates. Third, using diffusion Monte Carlo we will study the Bose-Fermi mixture. Varying the interaction we hope to discover and characterize the regime of ultra dilute liquid. We expect our research will be useful for guiding and interpreting future experiments.]]></summary_en></project><project>
<id>18836</id><title_hr><![CDATA[INNO2MARE - Strengthening the capacity for excellence of Slovenian and Croatian innovation ecosystems to support the digital and green transitions of maritime regions]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4775</user_id><user_firstLast_name>Marina Ivašić-Kos</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-9165</code><acronim><![CDATA[]]></acronim><duration>12.11.2025 - 11.11.2031</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Informacijske znanosti, </scie_field_hr><scie_field_en>Information sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Fakultet informatike i digitalnih tehnologija]]></institution_hr><institution_en><![CDATA[University or Rijeka, Faculty of Informatics and Digital Technologies]]></institution_en><team_members_id>872956</team_members_id><team_members_names><![CDATA[ Doktorand: Domagoj Palinić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>18842</id><title_hr><![CDATA[Praćenje izvora CO2 u atmosferi]]></title_hr><title_en><![CDATA[Tracking CO2 sources in the atmosphere]]></title_en><user_id>1159</user_id><user_firstLast_name>Jadranka Barešić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2025-02</proposal_call><code>IP-2025-02-1473</code><acronim><![CDATA[C-TRACK]]></acronim><duration>08.12.2025 - 07.12.2028</duration><status>U tijeku</status><financ_value>199.973,40 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Interdisciplinarne prirodne znanosti, </scie_field_hr><scie_field_en>Interdisciplinary natural sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>23812, 23823, 866163, 3789, </team_members_id><team_members_names><![CDATA[Damir  Borković, Ivanka Lovrenčić Mikelić, Boris Mifka, Andreja Sironić, ]]></team_members_names><keywords_hr><![CDATA[CO2, izotopi 13C i 14C, fosilna goriva, otopljeni anorganski ugljik (DIC), more, atmosfera, tlo, fotosinteza]]></keywords_hr><keywords_en><![CDATA[CO2, isotopes 13C and 14C, fossil fuels, dissolved inorganic carbon (DIC), sea, atmosphere, soil, photosynthesis ]]></keywords_en><summary_hr><![CDATA[Porast globalne temperature koji se bilježi od kraja 19. stoljeća povezuje se s porastom koncetracije stakleničkih plinova u atmosferi, pogotovo s oslobađanjem CO2 uslijed upotrebe fosilnih goriva.Osim antropogenog utjecaja, na koncentraciju atmosferskog CO2 utječu i prirodni procesi poput fotosinteze i respiracije tla, izmjena CO2 između mora i atmosfere, te prirodne sezonske fluktuacije. U okviru predloženog projekta pokušat će se utvrditi izvori i ponori CO2 u atmosferi pomoću izotopa ugljika, radioaktivnog 14C i stabilnog 13C (koncentracije relativno prema 12C, ?14C, ?13C). Izotop 14C je obilježivač atmosferskog CO2 te je jedinstveni način utvrđivanja ugljika fosilnog porijekla jer fosilna goriva ne sadrže 14C. Zbog oslobađanja CO2 u atmosferu uslijed izgaranja fosilnih goriva, ?14C atmosferskog CO2 se smanjuje. Ipak, samo pomoću ?14C nije moguće kvantificirati i sve doprinose nastale uslijed prirodnih procesa što može utjecati na izračun fosilnog doprinosa, te se kao alat dodatno koristi ?13C.Cilj projekta je praćenje udjela pojedinih komponenti CO2 u atmosferi. U tu svrhu pratit će se koncentracija, ?14C i ?13C atmosferskog CO2 u Hrvatskoj na 2 lokacije kontinentalne klime (urbana Zagreb i, „čista“ Puntijarka, Medvednica) i 3 lokacije mediteranske/planinske klime (urbana Rijeka i „čiste“ hrid Porer kraj Medulina i Parg, Risnjak). Dodatno će se na 2 lokacije (Porer i Rijeka) pratiti ?14C i ?13C i u otopljenom anorganskom ugljiku (DIC) u moru.Uzorkovanje na hridi Porer posebno je značajno jer su podaci o ?14C i ?13C CO2 iznad mora, te DIC-a vrlo rijetki na globalnoj razini. Temeljem navedenog očekujemo da će projekt biti značajan svima koji se bave ciklusom ugljika te istraživanjem i zaštitom okoliša. U okviru projekta planira se zaposlenje poslijedoktoranda i niz raznih diseminacijskih aktivnosti uključujući završnu radionicu.]]></summary_hr><summary_en><![CDATA[The increase in global temperature recorded since the end of the 19th century is associated with an increase in the atmospheric greenhouse gases concentration, especially with the fossil fuel produced CO2.Apart from the anthropogenic influence, the concentration of atmospheric CO2 is affected by natural processes such as photosynthesis and soil respiration, the sea-atmosphere CO2 exchange, and natural seasonal fluctuations. The proposed project will attempt to determine the sources and sinks of CO2 in the atmosphere using the isotopes of carbon, radioactive 14C and stable 13C (relative to 12C, ?14C, ?13C). Isotope 14C is a tracer of the atmospheric CO2, and is a unique way of determining carbon of fossil origin since fossil fuels do not contain 14C and their influence decreases ?14C in the atmospheric CO2. However, it is not possible to quantify all contributions from natural processes using ?14C alone, which affects the calculation of the fossil contribution. Therefore, ?13C is additionally used as a tool.The aim of the project is to monitor the share of CO2 from different sources in the atmosphere. For this purpose, concentration, ?14C and ?13C of atmospheric CO2 will be monitored in Croatia at 2 locations with a continental climate (urban Zagreb and &#39;&#39;clean&#39;&#39; Puntjarka, Medvednica mountain) and 3 locations with a Mediterranean/mountainous climate (urban Rijeka and &#39;&#39;clean&#39;&#39; Porer cliff near Medulin and Parg, Risnjak mountain). Additionally, ?14C and ?13C of the sea dissolved inorganic carbon (DIC) at Porer and in Rijeka will be monitored.Sampling at Porer cliff is particularly significant because data on ?14C and ?13C above sea surface CO2 and of DIC are very rare on a global scale. We expect that the project will be interesting for everyone involved in the carbon cycle and environmental research and protection. The project plans to employ a postdoctoral fellow and a number of disseminations, such as final workshop.]]></summary_en></project><project>
<id>18843</id><title_hr><![CDATA[Just Bonding. Filiation in Private International Law between Biology, Law, and Society]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5986</user_id><user_firstLast_name>Mirela Župan</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-1262</code><acronim><![CDATA[]]></acronim><duration>08.01.2026 - 07.01.2032</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Pravo, </scie_field_hr><scie_field_en>Law, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Pravni fakultet u Osijeku]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Law]]></institution_en><team_members_id>873062</team_members_id><team_members_names><![CDATA[ Doktorand: Karla Oberkirš ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>18852</id><title_hr><![CDATA[Razvoj polimera s otiskom molekula za primjenu u analizi farmaceutika i tijekom naprednih postupaka obrade voda]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4391</user_id><user_firstLast_name>Dragana Mutavdžić Pavlović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-3589</code><acronim><![CDATA[MIPdePharma]]></acronim><duration>11.11.2025 - 10.11.2031</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet kemijskog inženjerstva i tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Chemical Engineering and Technology]]></institution_en><team_members_id>872909</team_members_id><team_members_names><![CDATA[ Doktorand: Leona Čakić ]]></team_members_names><keywords_hr><![CDATA[polimeri s otiskom molekule, farmaceutici, računalne simulacije, priprava uzorka, sorpcija, fotokataliza]]></keywords_hr><keywords_en><![CDATA[molecularly imprinted polymers, pharmaceuticals, computational simulation, sample preparation, sorption, photocatalysis]]></keywords_en><summary_hr><![CDATA[Farmaceutici se kontinuirano unose u okoliš, a njihova potrošnja bilježi uzlaznu putanju zbog pojave novih bolesti, ali i broja oboljenja. Svi oni prije ili poslije završe u vodama tako da kontinuirano treba raditi na poboljšanju postojećih te razvoju novih analitičkih protokola za njihovo određivanje. Zbog velikog broja različitih komponenti koji se mogu naći u realnim uzorcima posebice u situacijama kada u uzorku imamo spojeve različite polarnosti sam postupak pripreme uzorka za analizu primjenom komercijalnih sorbensa postaje nedostatan. S druge strane problem se javlja i tijekom različitih postupaka obrade vode jer je velika većina organskih zagađivala pa tako i farmaceutika postojana u okolišu i teško razgradljiva. Projekt MIPdePharma će se baviti pripremom polimernih sorbensa s otiskom (MIP) ciljane molekule na više različitih načina u ispitivanom području primjene (priprava uzorka, sorpcija i fotokataliza), a sve s ciljem rješavanja prethodno navedenih problema. To će se postići provedbom velikog broja eksperimenata, pregledom literature te na osnovu fizikalno-kemijskih karakteristika ciljane molekule kroz sinergiju između iskusnih istraživača iz područja analitičke kemije, znanosti o okolišu, kemije materijala i računalne kemije. Primjena računalne kemije, uključivat će predviđanje najpovoljnije strukture istraživanih sustava koji bi trebali utjecati na smjer daljnjih eksperimenata, a koji će značajno skratiti postupak njihove pripreme te smanjiti primjenu velike količine standardne tvari ciljane molekule farmaceutika potrebnog za molekularno utiskivanje. Na kraju će se za sve pripremljene sorbense ispitati ostvarena učinkovitost. Kod postupka pripreme uzorka ona će se usporediti s učinkovitošću na komercijalno dostupnim sorbensima, dok će se u slučaju razvoja inovativnih tehnologija obrade otpadnih voda utvrditi i energetska učinkovitost svakog pojedinačnog procesa.]]></summary_hr><summary_en><![CDATA[Drugs are constantly being introduced into the environment, and their consumption is constantly increasing due to the emergence of new diseases and number of diseases. They all end up in the water, so it is necessary to work on improving existing and developing new analytical protocols for their determination. Due to the large number of components that can be found in real samples, especially in situations where compounds of different polarity are present in the sample, the sample preparation for analysis with commercial sorbents is insufficient. On the other hand, the problem also occurs in various water treatment processes, since the vast majority of organic pollutants, including pharmaceuticals, are persistent and difficult to degrade in the environment.The MIPdePharma project will address the preparation of molecularly imprinted polymer (MIP) with target molecule in different ways in the studied application area (sample preparation, sorption and photocatalysis), all with the aim of solving the above problems. This will be achieved by performing a large number of experiments, reviewing the literature and based on the physicochemical properties of the target molecule through the synergy between experienced researchers in the fields of analytical chemistry, environmental science, materials chemistry and computational chemistry. The application of computational chemistry will involve the prediction of the most favorable structure of the studied systems, which should influence the direction of further experiments, and will significantly shorten the process of their preparation and reduce the use of a large amount of the standard substance of the pharmaceutical target required for MIP. At the end, the obtained MIP efficiency will be tested. For sample preparation, it will be compared with the efficiency of commercially sorbents, while for the development of innovative wastewater treatment technologies, the energy efficiency of each process will be determined.]]></summary_en></project><project>
<id>18854</id><title_hr><![CDATA[BIOMONITORING_Dendronetwork]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3754</user_id><user_firstLast_name>Stjepan Mikac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-9654</code><acronim><![CDATA[]]></acronim><duration>14.11.2025 - 13.11.2031</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Šumarstvo, </scie_field_hr><scie_field_en>Forestry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet šumarstva i drvne tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Forestry and Wood Technology]]></institution_en><team_members_id>872949</team_members_id><team_members_names><![CDATA[ Doktorand: Laura Miketin ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>18855</id><title_hr><![CDATA[Evaluation on the long-term behaviour of natural and cementitious geomaterials]]></title_hr><title_en><![CDATA[]]></title_en><user_id>13353</user_id><user_firstLast_name>Goran Baloević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-4739</code><acronim><![CDATA[]]></acronim><duration>01.12.2025 - 01.12.2031</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Građevinarstvo, </scie_field_hr><scie_field_en>Civil engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu Fakultet građevinarstva, arhitekture i geodezije]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Civil Engineering, Architecture and Geodesy]]></institution_en><team_members_id>872955</team_members_id><team_members_names><![CDATA[ Doktorand: Mario Filipović ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>18856</id><title_hr><![CDATA[Inovativne metode istraživanja u svrhu procjene potencijala geotermalne energije i pohrane toplinske energije]]></title_hr><title_en><![CDATA[]]></title_en><user_id>13694</user_id><user_firstLast_name>Marija Macenić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-9015</code><acronim><![CDATA[InnoGeoPot]]></acronim><duration>24.11.2025 - 23.11.2031</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Rudarstvo, nafta i geološko inženjerstvo, </scie_field_hr><scie_field_en>Mining, petroleum and geological engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Rudarsko-geološko-naftni fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mining, Geology and Petroleum Engineering]]></institution_en><team_members_id>872970</team_members_id><team_members_names><![CDATA[ Doktorand: Vedrana Filipović ]]></team_members_names><keywords_hr><![CDATA[geotermalna energija, srednje-duboki BHE, pohrana toplinske energije - BTES, revitalizacija bušotina, termodinamičko-hidrauličko modeliranje]]></keywords_hr><keywords_en><![CDATA[geothermal energy, medium-deep BHE, thermal energy storage - BTES, well revitalization, thermal-hydrualic modelling]]></keywords_en><summary_hr><![CDATA[Uz stalno povećanje broja instaliranih sustava bušotinskih izmjenjivača topline (BHE) u Europi, prepoznata je potreba i iskorištavanje toplinske energije sadržane u dubljim horizontima podzemnih slojeva tla i stijena. U odabranim pilot područjima još nije provedeno istraživanje geotermalnog potencijala na dubinama između 200 i 500 m koristeći bušotinske izmjenjivače topline. Ovim projektom namjerava se uspostaviti geološko-hidrogeološko-termodinamički model korištenjem podataka prikupljenih tijekom bušenja dubokih bušotina u odabranim područjima (neobrađeni geološki i hidrogeološki podaci) kao i praćenjem stvarnih podataka iz polja plitkih geotermalnih izmjenjivača u radu te određivanjem toplinskih prinosa sustava. Nadalje, iskorištavanje plitkog i srednje dubokog geotermalnog potencijala može se proširiti i na primjenu skladištenja toplinske energije u stijeni bušotinskim izmjenjivačima (BTES), kao i na mogućnost iskorištavanja geotermalnog potencijala revitalizacijom napuštenih bušotina. Razvijeni geološko-hidrogeološko-geotermalni model će biti važan jer će osigurati bolji uvid u plitki i srednje duboki geotermalni potencijal područja, te definiranje područja gdje je moguće koristiti podzemlje za BTES. Također će se razmotriti procjena geotermalnog potencijala kroz revitalizaciju napuštenih bušotina. Područje istraživanja u Hrvatskoj obuhvaća šire područje grada Zagreba, grada Ljubljane i pograničnog područja između SI Slovenije i JI Hrvatske.Trilateralna suradnja Hrvatske, Švicarske i Slovenije na ovom projektu dovest će do formiranja međunarodne istraživačke skupine koja će se baviti karakterizacijom podzemlja i razvojem tehnologije u području geotermalne energije. Za odabrana pilot područja pravovremeni DSS za plitko i srednje duboko korištenje geotermalne energije bit će vrlo koristan alat koji će osigurati učinkovitije i održivije korištenje geotermalne energije.]]></summary_hr><summary_en><![CDATA[With the constant increase in the number of installed borehole heat exchangers (BHE) systems in Europe, the need and utilization of thermal energy contained in deeper geological layers has been recognized. In selected urban and rural pilot areas in Croatia and Slovenia, the investigation of geothermal potentials at medium-depths, between 200 & 500 m, via BHE has not yet been carried out. The proposed research intends to establish different scale geological-hydrogeological-thermal models using data collected during drilling of deep wells in selected areas (geological and hydrogeological raw data) as well as monitoring real data from shallow geothermal borehole field in operation to determine heat rejection/extraction rates. Furthermore, the exploitation of shallow and medium-deep geothermal potential can be extended to the application of borehole thermal energy system (BTES), as well as the possibility of exploiting geothermal potentials by revitalizing abandoned wells via deep closed-loop BHE. The developed geological-hydrogeological-geothermal model, along with a decision-support system (DSS), is important as it will provide a better insight into the shallow and medium-deep geothermal potential of the studied pilot areas as well as defining areas where it is possible to use BTES. Also, the evaluation of the geothermal potential through the revitalization of abandoned wells will be considered. The research area in Croatia covers the wider area of the city of Zagreb, the city of Ljubljana and the transboundary area between NE Slovenia and SE Croatia.Croatian, Swiss and Slovenian trilateral cooperation on this project will lead to forming an international research group dealing with subsurface characterization and technology development in the field of geothermal energy. For selected pilot areas timely DSS for shallow and medium-deep geothermal energy utilization will be a very useful tool that will ensure more efficient and sustainable geothermal energy utilization.]]></summary_en></project><project>
<id>18858</id><title_hr><![CDATA[Otkrivanje regulatorne mreže gena za glikozilaciju imunoglobulina G upotrebom molekularnih alata CRISPR/dCas9 ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5416</user_id><user_firstLast_name>Vlatka Zoldoš</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-7380</code><acronim><![CDATA[IgGeneNET]]></acronim><duration>01.02.2026 - 31.01.2032</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>873095</team_members_id><team_members_names><![CDATA[ Doktorand: Kristina Nikolić ]]></team_members_names><keywords_hr><![CDATA[regulacija gena, CRISPR/dCas9, epigenetika, IgG glikozilacija, upalne bolesti, GWAS, HEK293 Free Style, limfoblastoična stanična linija]]></keywords_hr><keywords_en><![CDATA[gene regulation, CRISPR/dCas9, epigenetics, IgG glycosylation, inflammatory diseases, GWAS, HEK293 Free Style, LCL cell line]]></keywords_en><summary_hr><![CDATA[U projektu ćemo idntificirati mrežu gena uključenu u regulaciju glikozilacije imunoglobulina G (IgG). Glikani vezani za Fc regiju molekule IgG određuju strukturu i efektorske funkcije antitijela. Galaktozilirani i sijalinizirani glikani vezani na Fc regiju IgGa imaju protuupalni učinak, dok sržna fukoza štiti od štetnog ADCC. Glikozilacija IgG promijenjena je u kroničnim upalnim i autoimunim bolestima i raku, a mijenja se i starenjem. Otprilike 15% IgG antitijela ima glikoziliranu Fab regiju za koju je pokazano da je povezana s gubitkom tolerancije u autoimunim bolestima. Nekoliko cijelogenomskih studija povezanosti  IgG glikoma identificiralo je 29 novih genskih lokusa sa dosad nepoznatom ulogom u glikozilaciji IgG, a koji objašnjavaju oko 22% varijacije i imaju pleiotropan učinak na imunološki sustav i upalu. GWAS studije osnivaju se na in silico analizama, stoga je neophodna funkcionalna validacija kadidat genskih lokusa. U našoj istraživačkoj grupi razvijen je tranzijentni ekspresijski sustav baziran na stanicama FreeStyle™293F koje izlučuju IgG te imaju stabilno ugrađene fuzije VPR-dCas9 i KRAB-dCas9 za manipulaciju gena. Ovaj sustav omogućava manipulaciju gena i analizu glikozilacije IgGa u isto vrijeme. Sustav je validiran, a dobiveni rezultati  objavljeni su u 2 visoko rangirana časopisa u području. Glavni cilj predloženog projekta je razlučivanje kauzalnih odnosa alternativne glikozilacije IgG i upale te ostalih procesa povezanih sa starenjem. Projektom ćemo modificirati tranzijentni ekspresijski sustav HEK-293F u svrhu određivanja IgG Fab i Fc glikozilacije, te ćemo razviti sustav limfoblastoidnih stanicama  s ugrađenim dCas9 fuzijama u svrhu manipulacije istih kandidat gena, GWAS hitova. Integracija i korelacija podataka dobivenih pomoću tri različita sustava omogućiti će identifikaciju mreže gena uključene u regulaciju i alternativnu glikozilaciju IgG povezanu s upalom i ostalim bolestima.]]></summary_hr><summary_en><![CDATA[In this project we will dissect the gene network that regulating immunoglobulin G (IgG) glycosylation. The glycans on IgG  influence structural stability and effector functions of the antibody. Galactosylated and sialylated glycans on IgG Fc region have anti-inflammatory effect, while core fucose acts as a safety switch against harmful ADCC. IgG glycosylation is altered in chronic inflammatory and autoimmune diseases and cancer, as well as in ageing. Approximately 15% of IgG antibodies also have  glycosylated Fab region, which seems to be implicated in the loss of tolerance in autoimmune diseases. Several genome wide associated studies (GWAS) of IgG glycome identified 29 novel gene loci with yet unknown roles in IgG glycosylation that explain up to 22% of variance and are pleiotropic with immune function and inflammation. Since GWAS is a data-driven approach there is a need for functional follow-up of the identified genes. For this purpose we developed an in vitro transient expression system based on FreeStyleTM293-F (HEK-293F) cells secreting IgG, with stably integrated VPR-dCas9 and KRAB-dCas9 fusions for gene manipulations. The system is elegant because it allows gene manipulations and analysis of resulting IgG glycan phenotype in one step. The system is validated and results are published in two highly ranked journals in the field. The main objective of this project is to elucidate a causative relationship between alternative IgG glycosylation and inflammation and other age-related processes. We will modify the HEK-293F transient expression system for analysis of both IgG Fab and Fc glycosylation. Furthermore, we will design system based on lymphoblastoid cells LCL-HD0016 with integrated dCas9-fusions for gene manipulations and glycan analysis in one step. Correlation of the data, generated by the three different systems, will allow dissecting the gene network responsible for regulation and alternative IgG Fc and Fab glycosylation associated with inflammation.]]></summary_en></project><project>
<id>18862</id><title_hr><![CDATA[Elektromagnetska karakterizacija bioloških tkiva i stanica za medicinske i biološke primjene]]></title_hr><title_en><![CDATA[]]></title_en><user_id>7748</user_id><user_firstLast_name>Antonio Šarolić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-3916</code><acronim><![CDATA[EMF-Med]]></acronim><duration>19.12.2025 - 18.12.2031</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Fakultet elektrotehnike, strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Electrical Engineering, Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>873029</team_members_id><team_members_names><![CDATA[ Doktorand: Viktoria Pavlovski ]]></team_members_names><keywords_hr><![CDATA[radiofrekvencijska i mikrovalna elektromagnetska polja, permitivnost, biološka tkiva i stanice, biomarkeri, senzori, medicinske i biološke primjene]]></keywords_hr><keywords_en><![CDATA[RF and microwave electromagnetic fields, permittivity, biological tissues and cells, biomarkers, sensors, medical and biological applications]]></keywords_en><summary_hr><![CDATA[Dielektrična permitivnost materijala je fizikalni parametar koji određuje način interakcije materijala s elektromagnetskim poljem u radiofrekvencijskom odnosno mikrovalnom frekvencijskom području. U sklopu ovog projekta planirana je elektromagnetska  karakterizacija bioloških tkiva, zdravih i patoloških, koreliranjem njihove permitivnosti s biokemijskim parametrima tkiva, odnosno sadržajem vode i drugih sastojaka u tkivu. Uz tako uspostavljenu korelaciju, permitivnost može poslužiti kao značajan biomarker u medicinskim i biološkim primjenama. Kao primjer medicinski značajnog biomarkera i pridružene aplikacije, u projektu je planiran razvoj prototipa neinvazivnog i nedestruktivnog elektroničkog senzora dielektričnog kontrasta za intraoperativnu diskriminaciju meningeoma od okolnog zdravog tkiva. Uz elektromagnetsku karakterizaciju na razini tkiva, provest će se i analiza permitivnosti populacije stanica u staničnoj kulturi. Izmjerena permitivnost korelirat će se s elektrofiziološkim parametrima pojedinačnih stanica iz populacije, kao i s općenitim fiziološkim stanjem populacije u vidu broja stanica i njihove vijabilnosti. Kao primjer biomedicinski značajnog biomarkera i pridružene aplikacije, u projektu je planiran razvoj prototipa neinvazivnog i nedestruktivnog elektroničkog senzora permitivnosti za kontinuirani nadzor bioloških parametara, prvenstveno vijabilnosti populacije stanica u staničnoj kulturi. U projektu će se koristiti inženjerske metode elektromagnetske analize simulacijama i mjerenjima, paralelno s analitičkim biokemijskim metodama i elektrofiziološkim metodama koje se koriste u biomedicinskim istraživanjima tkiva i stanica. U tom smislu projekt je vrlo interdisciplinaran, s konačnim rezultatima iz područja elektroničkih i elektromagnetskih senzora, ali s primjenom u medicini i biologiji. ]]></summary_hr><summary_en><![CDATA[Dielectric permittivity of a material is a physical parameter determining its interaction with electromagnetic field in the radiofrequency and microwave frequency range. Within this project we plan to electromagnetically characterize biological tissues, both healthy and pathological, by correlating their permittivity with their biochemical parameters, i.e. relative content of water and other tissue constituents. Based on such established correlation, permittivity can serve as a significant biomarker in medical and biological applications. As an example of a medically significant biomarker and the associated application, the project plans to develop a prototype of a non-invasive and non-destructive permittivity contrast sensor, applicable for intraoperative discrimination between meningioma tissue and the surrounding healthy tissues. Besides the electromagnetic characterization on the tissue level, the project will also analyze the permittivity of cell population in a cell culture. The measured permittivity will be correlated with the electrophysiological parameters of individual cells from the population, and with the general physiological state of the population in terms of cell count and cell viability. As an example of a biomedically significant biomarker and the associated application, the project plans to develop a prototype of a non-invasive and non-destructive permittivity sensor for continuous monitoring of cell culture biological parameters, primarily the cell viability in the cell culture. The project will use the engineering methods of electromagnetic analysis using simulations and measurements, in parallel with the analytical biochemistry methods and electrophysiology methods, used in the biomedical research on tissues and cells. Accordingly, the project is highly interdisciplinary, with the final results within the field of electronic and electromagnetic sensors, albeit with the application in medicine and biology.]]></summary_en></project><project>
<id>18863</id><title_hr><![CDATA[Kognitivne pristranosti kao izvor suboptimalnih odluka u turizmu i problema (ne)održivosti: Razumijevanjem pristranosti do kvalitetnijeg upravljanja turizmom]]></title_hr><title_en><![CDATA[]]></title_en><user_id>13295</user_id><user_firstLast_name>Velibor Mačkić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2025-02</proposal_call><code>DOK-2025-02-9714</code><acronim><![CDATA[BIASTOUR]]></acronim><duration>24.11.2025 - 23.11.2031</duration><status>U tijeku</status><financ_value>72,00 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, </scie_field_hr><scie_field_en>Economy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Ekonomski fakultet u Zagrebu]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Economics and Business]]></institution_en><team_members_id>872951</team_members_id><team_members_names><![CDATA[ Doktorand: Julia Biloš ]]></team_members_names><keywords_hr><![CDATA[održivost turizma, bihevioralna ekonomija, kognitivne pristranosti, nadoknada ugljika, prekomjerni turizam, eksperiment odabira]]></keywords_hr><keywords_en><![CDATA[tourism sustainability, behavioural economics, cognitive biases, carbon offsets, overtourism, choice experiment]]></keywords_en><summary_hr><![CDATA[Predloženi projekt zasniva se na principima bihevioralne ekonomije, koji će se primijeniti u proučavanju kognitivnih pristranosti u percepciji i odlukama turista i lokalnog stanovništva, a koje su povezane s aspektima okolišne i društvene održivosti turizma. Bolje shvaćanje kognitivnih pristranosti i mehanizama donošenja odluka predstavlja značajan potencijal za povećanje učinkovitosti mjera i politika održivog razvoja turizma. U projektu će se sistematski ispitati potencijal afektivnih komponenti stavova u promicanju pro-okolišnog ponašanja, na primjeru usvajanja dobrovoljnih programa za nadoknadu ugljika. Također će se analizirati postojanje kognitivnih pristranosti u razmatranju takvih programa te preferencije turista prema obilježjima programa nadoknade ugljika. Kognitivne pristranosti prisutne su i u drugim aspektima turističkog iskustva, a u projektu će se analizirati kognitivne pristranosti koje potencijalno mogu objasniti zanemarivu važnost subjektivne ili objektivne razine korištenja zaštićenog prirodnog područja i zadovoljstva posjetitelja. Definirat će se metodološke smjernice za ublažavanja rizika iskrivljenog vrednovanja usluga ekosustava što će omogućiti stvaranje kvalitetnije informacijske osnovice za planove upravljanja zaštićenim prirodnim područjima. Hrvatske destinacije u sve većoj mjeri se suočavaju s problemima prekomjernog turizma, što ne samo da predstavlja rizike po okoliš, već stvara i rizike po dobrobit lokalnog stanovništva. Postojeća istraživanja su utvrdila kako postoji visoki rizik niza kognitivnih pristranosti prilikom donošenja odluke o potpori turizmu, a koje bi trebalo detaljnije istražiti. Stvaranjem metodološkog okvira za bolje razumijevanje (i)racionalnosti odluke o podršci turističkom razvoju, ovim projektom će se omogućiti formiranje politika turističkog razvoja kojima se dugoročno promiče dobrobit lokalnog stanovništva.]]></summary_hr><summary_en><![CDATA[This project is based on the principles of behavioural economics, which will be applied in the study of cognitive biases in the perception and decisions of tourists and local residents, in the context of environmental and social sustainability of tourism. A better understanding of cognitive biases and decision-making mechanisms represents untapped potential for increasing the effectiveness of measures and policies that support sustainable tourism development. During this project we will systematically examine the potential of affective components of attitude in promoting pro-environmental behaviour, i.e., voluntary carbon offsetting. We will also study the existence of cognitive biases in the consideration of voluntary carbon offsets and the preferences of tourists towards the attributes of carbon offsetting programs. Cognitive biases also exist in other aspects of tourism experience, and in this project we will analyse cognitive biases that can potentially explain the negligible importance of the subjective or objective use level of the protected natural area on visitor satisfaction. Methodological guidelines will be defined to mitigate the risk of distorted valuation of ecosystem services, which will enable the creation of a better information basis for managing protected natural areas. Croatian destinations are increasingly facing the problems of overtourism, which not only poses risks for the environment, but also creates risks for the well-being of the local population. Existing research indicates that there is a high risk of a number of cognitive biases when making a decision on supporting tourism, which should be investigated in more detail. By creating a methodological framework that enables a better understanding of the (ir)rationality in the residents&#39; decisions to support tourism development, this project will support the formation of tourism development policies that promote the long-term well-being of the local population.]]></summary_en></project><project>
<id>18866</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Benjamin Radetić]]></title_hr><title_en><![CDATA[]]></title_en><user_id>867741</user_id><user_firstLast_name>Benjamin Radetić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-4549</code><acronim><![CDATA[]]></acronim><duration>03.11.2025 - 01.02.2026</duration><status>U tijeku</status><financ_value>7.735,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Interdisciplinarne tehničke znanosti, </scie_field_hr><scie_field_en>Interdisciplinary technological sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Geotehnički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Geotechnical Engineering]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>18867</id><title_hr><![CDATA[Uloga metabolizma indola u povećanju tolerancije kupusnjača (Brassicaceae) na abiotski stres]]></title_hr><title_en><![CDATA[Role of Indole Metabolism in Enhancing Abiotic Stress Tolerance in Brassicaceae]]></title_en><user_id>791</user_id><user_firstLast_name>Branka Salopek Sondi</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>WEAVE</proposal_type><proposal_call>2024</proposal_call><code>WEAVE-2024-2521</code><acronim><![CDATA[InMetaBra]]></acronim><duration>01.02.2026 - 31.01.2029</duration><status>U tijeku</status><financ_value>199.999,75 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>861744, 4710, 11110, 2889, </team_members_id><team_members_names><![CDATA[Iva Marković, Mirta Tkalec, Smiljana Goreta Ban, Nenad Jasprica, ]]></team_members_names><keywords_hr><![CDATA[abiotski stres, auksini, kupusnjače, divlji kupus (Brassica incana), metabolizam indola, glukozinolati]]></keywords_hr><keywords_en><![CDATA[abiotic stress, auxins, Brassica crops, wild cabbage (Brassica incana), indole metabolism, glucosinolates]]></keywords_en><summary_hr><![CDATA[Globalno zatopljenje i povezane klimatske promjene ozbiljna su prijetnja poljoprivrednoj proizvodnji i bioraznolikosti u svijetu. Suša i toplinski stres obično se javljaju zajedno i predstavljaju ozbiljne prepreke u proizvodnji usjeva i sigurnosti hrane. Stoga je ključno razumjeti mehanizme otpornosti biljaka na abiotski stres. Ovaj je projekt fokusiran na ulogu metabolizma indola specifičnog za kupusnjače (Brassicaceae), uključujući auksine i indolne glukozinolate, u toleranciji na abiotske stresove (sušu i povišenu temperaturu, pojedinačno i kombinirano). Spomenuti metaboliti indola uključeni su u odgovor na abiotski stres, iako njihova uloga u mehanizmima tolerancije još nije sustavno istražena. Projekt će integrirati terenska istraživanja, funkcionalnu genetiku, fiziologiju, biokemiju, transkriptomiku i ciljanu metabolomiku. Očekujemo da ćemo identificirati gene i metabolite odgovorne za povećanu otpornost divljih vrsta kupusnjača na klimatske promjene i pridonijeti boljem razumijevanju složenih mehanizama otpornosti na stres.]]></summary_hr><summary_en><![CDATA[Global warming and the associated climate changes are a serious threat to agricultural production and biodiversity in the world. Drought and heat stress tend to occur together and pose the greatest obstacles to crop production and food security. It is therefore crucial to understand the mechanisms of plant tolerance to abiotic stress. This project focuses on the role that Brassicaceae-specific modifications of indole metabolism, including auxins and indole glucosinolates, play in tolerance to abiotic stresses (drought and heat, individually and combined). Both indole metabolites are involved in the response to abiotic stress, although their role in tolerance mechanisms has not yet been systematically investigated. The project will integrate field research, functional genetics, physiology, biochemistry, transcriptomics and targeted metabolomics. We expect to identify genes and metabolites, responsible for the enhanced tolerance of wild Brassica species to climate changes and contribute to a better understanding of the complex mechanisms of stress tolerance.]]></summary_en></project><project>
<id>18869</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Dora Walter]]></title_hr><title_en><![CDATA[]]></title_en><user_id>871125</user_id><user_firstLast_name>Dora Walter</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-4779</code><acronim><![CDATA[]]></acronim><duration>05.09.2025 - 22.02.2026</duration><status>U tijeku</status><financ_value>14.535,00 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, </scie_field_hr><scie_field_en>Economy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Ekonomski fakultet u Zagrebu]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Economics and Business]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>18873</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Mario Zelić]]></title_hr><title_en><![CDATA[]]></title_en><user_id>865690</user_id><user_firstLast_name>Mario Zelić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-3567</code><acronim><![CDATA[]]></acronim><duration>19.09.2025 - 20.03.2026</duration><status>U tijeku</status><financ_value>15.555,00 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>18879</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Sandra Romac]]></title_hr><title_en><![CDATA[]]></title_en><user_id>869764</user_id><user_firstLast_name>Sandra Romac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-1464</code><acronim><![CDATA[]]></acronim><duration>20.09.2025 - 20.01.2026</duration><status>U tijeku</status><financ_value>10.455,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Kemijsko inženjerstvo, </scie_field_hr><scie_field_en>Chemical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet kemijskog inženjerstva i tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Chemical Engineering and Technology]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>18880</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Filip Grdović]]></title_hr><title_en><![CDATA[]]></title_en><user_id>869785</user_id><user_firstLast_name>Filip Grdović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-2303</code><acronim><![CDATA[]]></acronim><duration>12.09.2025 - 14.12.2025</duration><status>U tijeku</status><financ_value>7.990,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>18881</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Darija Borović]]></title_hr><title_en><![CDATA[]]></title_en><user_id>869869</user_id><user_firstLast_name>Darija Borović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-7779</code><acronim><![CDATA[]]></acronim><duration>19.09.2025 - 30.10.2025</duration><status>U tijeku</status><financ_value>3.570,00 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Agronomski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Agriculture]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>18882</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Robert Pendelić]]></title_hr><title_en><![CDATA[]]></title_en><user_id>868758</user_id><user_firstLast_name>Robert Pendelić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-5679</code><acronim><![CDATA[]]></acronim><duration>13.06.2026 - 31.07.2026</duration><status>U tijeku</status><financ_value>4.165,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>18883</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Noah Somun Somun]]></title_hr><title_en><![CDATA[]]></title_en><user_id>865494</user_id><user_firstLast_name>Noah Somun Somun</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-4419</code><acronim><![CDATA[]]></acronim><duration>16.08.2025 - 19.10.2025</duration><status>U tijeku</status><financ_value>5.525,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>18888</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Marina Čančar Lukić]]></title_hr><title_en><![CDATA[]]></title_en><user_id>870832</user_id><user_firstLast_name>Marina Čančar Lukić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-5596</code><acronim><![CDATA[]]></acronim><duration>01.09.2025 - 30.11.2025</duration><status>U tijeku</status><financ_value>7.735,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Geologija, </scie_field_hr><scie_field_en>Geology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>18889</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Dora Bošnjak]]></title_hr><title_en><![CDATA[]]></title_en><user_id>869735</user_id><user_firstLast_name>Dora Bošnjak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-1834</code><acronim><![CDATA[]]></acronim><duration>30.08.2025 - 04.10.2025</duration><status>U tijeku</status><financ_value>3.060,00 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Agronomski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Agriculture]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>18890</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Tomislav Rodinger]]></title_hr><title_en><![CDATA[]]></title_en><user_id>871135</user_id><user_firstLast_name>Tomislav Rodinger</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-2148</code><acronim><![CDATA[]]></acronim><duration>01.07.2025 - 30.09.2025</duration><status>U tijeku</status><financ_value>7.820,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, </scie_field_hr><scie_field_en>Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>18891</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Ivan Dlačić]]></title_hr><title_en><![CDATA[]]></title_en><user_id>869643</user_id><user_firstLast_name>Ivan Dlačić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-9169</code><acronim><![CDATA[]]></acronim><duration>30.08.2025 - 01.03.2026</duration><status>U tijeku</status><financ_value>15.640,00 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Institut za poljoprivredu i turizam]]></institution_hr><institution_en><![CDATA[Institute of Agriculture and Tourism in Poreč]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>18892</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Tina Domjanović]]></title_hr><title_en><![CDATA[]]></title_en><user_id>869830</user_id><user_firstLast_name>Tina Domjanović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-9142</code><acronim><![CDATA[]]></acronim><duration>11.08.2025 - 11.09.2025</duration><status>U tijeku</status><financ_value>2.720,00 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Split School of Medicine]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>18893</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Eva Ružić]]></title_hr><title_en><![CDATA[]]></title_en><user_id>871133</user_id><user_firstLast_name>Eva Ružić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-1929</code><acronim><![CDATA[]]></acronim><duration>01.09.2025 - 13.12.2025</duration><status>U tijeku</status><financ_value>8.840,00 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Pravo, </scie_field_hr><scie_field_en>Law, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Pravni fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Law]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>18898</id><title_hr><![CDATA[Oksimski protuotrovi za reaktivaciju kolinesteraza inhibiranih visoko toksičnim organofosfatima]]></title_hr><title_en><![CDATA[Oxime antidotes for reactivation of cholinesterases inhibited by highly poisonous organophosphates]]></title_en><user_id>489</user_id><user_firstLast_name>Goran Šinko</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>WEAVE</proposal_type><proposal_call>2024</proposal_call><code>WEAVE-2024-6205</code><acronim><![CDATA[REACT]]></acronim><duration>01.02.2026 - 31.01.2029</duration><status>U tijeku</status><financ_value>200.000,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Interdisciplinarne prirodne znanosti, Kemija, Biologija, </scie_field_hr><scie_field_en>Interdisciplinary natural sciences, Chemistry, Biology, </scie_field_en><institution_hr><![CDATA[Institut za medicinska istraživanja i medicinu rada]]></institution_hr><institution_en><![CDATA[Institute for Medical Research and Occupational Health]]></institution_en><team_members_id>982, 861724, 871143, </team_members_id><team_members_names><![CDATA[Maja Katalinić, Dora Kolić, Petra Tuksar, ]]></team_members_names><keywords_hr><![CDATA[organofostat, reactivator, oxim, acetilkolinesteraza, butirilkolinesteraza]]></keywords_hr><keywords_en><![CDATA[organophosphate, reactivator, oxime, acetylcholinesterase, butyrylcholinesterase]]></keywords_en><summary_hr><![CDATA[Visoko toksični organofosforni spojevi korišteni su tijekom ozbiljnih incidenata u prošlom desetljeću. Ovi agensi uzrokuju po život opasna otrovanja koja se obično liječe kombinacijom protuotrova, pri čemu samo reaktivatori (oksimi) mogu ukloniti organofosfate iz aktivnog mjesta kolinesteraze i obnoviti njezinu fiziološku aktivnost. Međutim, pokazalo se da su standardni oksimi neučinkoviti protuotrovi za tako visoko toksične organofosforne spojeve. Iz tih razloga, trenutno istraživanje temelji se na istraživanju oksima s povećanom reaktivacijom za specifične organofosfate. Stoga je ovaj projekt usmjeren na potvrdu koncepta povećane reaktivacije organofosfata i zaštite organizma korištenjem dvostruko nabijenih piridinijevih oksima, koji će biti dizajnirani, pripremljeni i temeljito evaluirani za ove potrebe.]]></summary_hr><summary_en><![CDATA[The highly toxic organophosphorus compounds were used during serious incidents in the last decade. These agents are causing life endangering intoxication that are usually treated by combination of antidotes, where only reactivators (oximes) are able to split organophosphates from cholinesterase active site and restore their physiologic activity. However, the standard oximes were found ineffective antidotes for such highly toxic organophosphorus compounds. For these reasons, the current research is based on searching for oximes with increased reactivation for the specific organophosphates. Thus, this project is focused on proof of concept of increased organophosphate reactivation and organism protection using double charged pyridinium oximes, which will be designed, prepared and thoroughly evaluated for these purposes.]]></summary_en></project><project>
<id>18911</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Valentina Barukčić]]></title_hr><title_en><![CDATA[]]></title_en><user_id>867519</user_id><user_firstLast_name>Valentina Barukčić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-3071</code><acronim><![CDATA[]]></acronim><duration>01.10.2025 - 02.02.2026</duration><status>U tijeku</status><financ_value>10.625,00 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Agronomski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Agriculture]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>18912</id><title_hr><![CDATA[Odlazna mobilnost asistenata - AGATA DAJČIĆ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>869907</user_id><user_firstLast_name>AGATA DAJČIĆ</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-2321</code><acronim><![CDATA[]]></acronim><duration>27.10.2025 - 15.03.2026</duration><status>U tijeku</status><financ_value>11.900,00 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Pravo, </scie_field_hr><scie_field_en>Law, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Pomorski fakultet ]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Maritime Studies]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>18914</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Helena Biljanić]]></title_hr><title_en><![CDATA[]]></title_en><user_id>867449</user_id><user_firstLast_name>Helena Biljanić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-7329</code><acronim><![CDATA[]]></acronim><duration>19.10.2025 - 16.01.2026</duration><status>U tijeku</status><financ_value>7.650,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>18915</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Anita Tarandek]]></title_hr><title_en><![CDATA[]]></title_en><user_id>868717</user_id><user_firstLast_name>Anita Tarandek</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-6086</code><acronim><![CDATA[]]></acronim><duration>16.03.2026 - 28.04.2026</duration><status>U tijeku</status><financ_value>3.740,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>18916</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Matko Jelašić]]></title_hr><title_en><![CDATA[]]></title_en><user_id>865921</user_id><user_firstLast_name>Matko Jelašić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-7831</code><acronim><![CDATA[]]></acronim><duration>01.10.2025 - 02.04.2026</duration><status>U tijeku</status><financ_value>15.640,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, </scie_field_hr><scie_field_en>Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>18919</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Veronika Bencerić]]></title_hr><title_en><![CDATA[]]></title_en><user_id>869627</user_id><user_firstLast_name>Veronika Bencerić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-4823</code><acronim><![CDATA[]]></acronim><duration>12.12.2025 - 31.03.2026</duration><status>U tijeku</status><financ_value>9.350,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut za antropologiju]]></institution_hr><institution_en><![CDATA[Institute for Anthropological Research]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>18921</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Karlo Kožina]]></title_hr><title_en><![CDATA[]]></title_en><user_id>872151</user_id><user_firstLast_name>Karlo Kožina</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-1920</code><acronim><![CDATA[]]></acronim><duration>15.11.2025 - 01.02.2026</duration><status>U tijeku</status><financ_value>6.715,00 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Pravo, </scie_field_hr><scie_field_en>Law, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Pravni fakultet u Zagrebu]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Law]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>18922</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Iva Vojtkuf]]></title_hr><title_en><![CDATA[]]></title_en><user_id>869787</user_id><user_firstLast_name>Iva Vojtkuf</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-1928</code><acronim><![CDATA[]]></acronim><duration>08.10.2025 - 06.04.2026</duration><status>U tijeku</status><financ_value>15.385,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>18923</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Lucija Marcelić]]></title_hr><title_en><![CDATA[]]></title_en><user_id>869802</user_id><user_firstLast_name>Lucija Marcelić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-1279</code><acronim><![CDATA[]]></acronim><duration>07.11.2025 - 20.12.2025</duration><status>U tijeku</status><financ_value>3.740,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut za medicinska istraživanja i medicinu rada]]></institution_hr><institution_en><![CDATA[Institute for Medical Research and Occupational Health]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>18924</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Anastazija Huđ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>869784</user_id><user_firstLast_name>Anastazija Huđ</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-6038</code><acronim><![CDATA[]]></acronim><duration>16.11.2025 - 19.12.2025</duration><status>U tijeku</status><financ_value>2.890,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>18927</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Iva Palatinuš]]></title_hr><title_en><![CDATA[]]></title_en><user_id>866735</user_id><user_firstLast_name>Iva Palatinuš</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-4654</code><acronim><![CDATA[]]></acronim><duration>27.10.2025 - 24.04.2026</duration><status>U tijeku</status><financ_value>15.300,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Geologija, </scie_field_hr><scie_field_en>Geology, </scie_field_en><institution_hr><![CDATA[Hrvatski geološki institut]]></institution_hr><institution_en><![CDATA[Croatian Geological Survey]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>18928</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Marko Gobin]]></title_hr><title_en><![CDATA[]]></title_en><user_id>870353</user_id><user_firstLast_name>Marko Gobin</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-2478</code><acronim><![CDATA[]]></acronim><duration>01.12.2025 - 30.04.2026</duration><status>U tijeku</status><financ_value>12.835,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>18929</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Nikolina Raguž-Lučić]]></title_hr><title_en><![CDATA[]]></title_en><user_id>872260</user_id><user_firstLast_name>Nikolina Raguž-Lučić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-3780</code><acronim><![CDATA[]]></acronim><duration>29.10.2025 - 28.11.2025</duration><status>U tijeku</status><financ_value>2.635,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Arhitektura i urbanizam, </scie_field_hr><scie_field_en>Architecture and Urban Environment, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Građevinski i arhitektonski fakultet Osijek]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Civil Engineering and Architecture Osijek]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>18930</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Nikolina Golub]]></title_hr><title_en><![CDATA[]]></title_en><user_id>865170</user_id><user_firstLast_name>Nikolina Golub</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-1676</code><acronim><![CDATA[]]></acronim><duration>15.12.2025 - 02.06.2026</duration><status>U tijeku</status><financ_value>14.450,00 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Farmacija, </scie_field_hr><scie_field_en>Pharmaceutical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Farmaceutsko-biokemijski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Pharmacy and Biochemistry]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>18931</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Krunoslav Jurčić]]></title_hr><title_en><![CDATA[]]></title_en><user_id>872264</user_id><user_firstLast_name>Krunoslav Jurčić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-4177</code><acronim><![CDATA[]]></acronim><duration>03.11.2025 - 02.05.2026</duration><status>U tijeku</status><financ_value>15.385,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>18937</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Valentina Lovrić]]></title_hr><title_en><![CDATA[]]></title_en><user_id>869728</user_id><user_firstLast_name>Valentina Lovrić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-2989</code><acronim><![CDATA[]]></acronim><duration>02.03.2026 - 29.05.2026</duration><status>U tijeku</status><financ_value>7.565,00 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Šumarstvo, </scie_field_hr><scie_field_en>Forestry, </scie_field_en><institution_hr><![CDATA[Hrvatski šumarski institut]]></institution_hr><institution_en><![CDATA[Croatian Forest Research Institute]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>18943</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Filip Badovinac]]></title_hr><title_en><![CDATA[]]></title_en><user_id>867770</user_id><user_firstLast_name>Filip Badovinac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-3596</code><acronim><![CDATA[]]></acronim><duration>01.01.2026 - 01.03.2026</duration><status>U tijeku</status><financ_value>5.100,00 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, </scie_field_hr><scie_field_en>Economy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Ekonomski fakultet u Zagrebu]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Economics and Business]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>18944</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Franjo Sakoman]]></title_hr><title_en><![CDATA[]]></title_en><user_id>869774</user_id><user_firstLast_name>Franjo Sakoman</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-8156</code><acronim><![CDATA[]]></acronim><duration>31.01.2026 - 01.04.2026</duration><status>U tijeku</status><financ_value>5.185,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>18946</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Petra Jeršek]]></title_hr><title_en><![CDATA[]]></title_en><user_id>867794</user_id><user_firstLast_name>Petra Jeršek</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-5569</code><acronim><![CDATA[]]></acronim><duration>05.01.2026 - 05.04.2026</duration><status>U tijeku</status><financ_value>7.735,00 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Arheologija, </scie_field_hr><scie_field_en>Archeology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>18948</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Antonio Milovina]]></title_hr><title_en><![CDATA[]]></title_en><user_id>865367</user_id><user_firstLast_name>Antonio Milovina</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-4588</code><acronim><![CDATA[]]></acronim><duration>26.01.2026 - 26.02.2026</duration><status>U tijeku</status><financ_value>2.720,00 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filologija, </scie_field_hr><scie_field_en>Philology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>18952</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Tila Medenica]]></title_hr><title_en><![CDATA[]]></title_en><user_id>866446</user_id><user_firstLast_name>Tila Medenica</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-2721</code><acronim><![CDATA[]]></acronim><duration>12.01.2026 - 06.03.2026</duration><status>U tijeku</status><financ_value>4.590,00 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>18953</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Petar Sačer]]></title_hr><title_en><![CDATA[]]></title_en><user_id>866120</user_id><user_firstLast_name>Petar Sačer</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-1840</code><acronim><![CDATA[]]></acronim><duration>29.01.2026 - 31.07.2026</duration><status>U tijeku</status><financ_value>15.640,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>18954</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Antonela Blažević]]></title_hr><title_en><![CDATA[]]></title_en><user_id>869790</user_id><user_firstLast_name>Antonela Blažević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-1838</code><acronim><![CDATA[]]></acronim><duration>10.01.2026 - 14.02.2025</duration><status>U tijeku</status><financ_value>3.060,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>18955</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Dario Šušnić]]></title_hr><title_en><![CDATA[]]></title_en><user_id>870491</user_id><user_firstLast_name>Dario Šušnić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-5846</code><acronim><![CDATA[]]></acronim><duration>27.02.2026 - 31.05.2026</duration><status>U tijeku</status><financ_value>7.990,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>18956</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Katja Mužek]]></title_hr><title_en><![CDATA[]]></title_en><user_id>872849</user_id><user_firstLast_name>Katja Mužek</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-2468</code><acronim><![CDATA[]]></acronim><duration>01.03.2026 - 30.06.2026</duration><status>U tijeku</status><financ_value>10.370,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Geologija, </scie_field_hr><scie_field_en>Geology, </scie_field_en><institution_hr><![CDATA[Hrvatski geološki institut]]></institution_hr><institution_en><![CDATA[Croatian Geological Survey]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>18967</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Zoran Malbaša]]></title_hr><title_en><![CDATA[]]></title_en><user_id>869481</user_id><user_firstLast_name>Zoran Malbaša</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-5557</code><acronim><![CDATA[]]></acronim><duration>20.04.2026 - 20.07.2026</duration><status>U tijeku</status><financ_value>7.820,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Kemijsko inženjerstvo, </scie_field_hr><scie_field_en>Chemical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet kemijskog inženjerstva i tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Chemical Engineering and Technology]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>18968</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Marko Starčević]]></title_hr><title_en><![CDATA[]]></title_en><user_id>868528</user_id><user_firstLast_name>Marko Starčević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-6891</code><acronim><![CDATA[]]></acronim><duration>01.04.2026 - 31.07.2026</duration><status>U tijeku</status><financ_value>10.370,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Interdisciplinarne tehničke znanosti, </scie_field_hr><scie_field_en>Interdisciplinary technological sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>18969</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Juraj Perić]]></title_hr><title_en><![CDATA[]]></title_en><user_id>872884</user_id><user_firstLast_name>Juraj Perić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-8308</code><acronim><![CDATA[]]></acronim><duration>27.04.2026 - 26.06.2026</duration><status>U tijeku</status><financ_value>5.185,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera Osijek, Fakultet elektrotehnike, računarstva i informacijskih tehnologija Osijek]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Electrical Engineering, Computer Science and Information Technology Osijek]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>18972</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Tajana Horvat]]></title_hr><title_en><![CDATA[]]></title_en><user_id>867793</user_id><user_firstLast_name>Tajana Horvat</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-7334</code><acronim><![CDATA[]]></acronim><duration>18.05.2026 - 27.06.2026</duration><status>U tijeku</status><financ_value>3.485,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Kemijsko inženjerstvo, </scie_field_hr><scie_field_en>Chemical engineering, </scie_field_en><institution_hr><![CDATA[Institut za medicinska istraživanja i medicinu rada]]></institution_hr><institution_en><![CDATA[Institute for Medical Research and Occupational Health]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>18973</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Laura Busak]]></title_hr><title_en><![CDATA[]]></title_en><user_id>872926</user_id><user_firstLast_name>Laura Busak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-8079</code><acronim><![CDATA[]]></acronim><duration>18.04.2026 - 17.07.2026</duration><status>U tijeku</status><financ_value>7.735,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>18974</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Josip Rešetar]]></title_hr><title_en><![CDATA[]]></title_en><user_id>869894</user_id><user_firstLast_name>Josip Rešetar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-5730</code><acronim><![CDATA[]]></acronim><duration>30.03.2026 - 31.07.2026</duration><status>U tijeku</status><financ_value>10.540,00 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Farmacija, </scie_field_hr><scie_field_en>Pharmaceutical sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>18978</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Marko Purić]]></title_hr><title_en><![CDATA[]]></title_en><user_id>870356</user_id><user_firstLast_name>Marko Purić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-7503</code><acronim><![CDATA[]]></acronim><duration>31.03.2026 - 31.07.2026</duration><status>U tijeku</status><financ_value>10.455,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>18979</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Sara Zeko]]></title_hr><title_en><![CDATA[]]></title_en><user_id>869922</user_id><user_firstLast_name>Sara Zeko</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-2249</code><acronim><![CDATA[]]></acronim><duration>13.03.2026 - 26.06.2026</duration><status>U tijeku</status><financ_value>9.010,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>18980</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Janja Josić]]></title_hr><title_en><![CDATA[]]></title_en><user_id>869751</user_id><user_firstLast_name>Janja Josić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-6299</code><acronim><![CDATA[]]></acronim><duration>01.04.2026 - 15.06.2026</duration><status>U tijeku</status><financ_value>6.460,00 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>18981</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Dora Lastovčić]]></title_hr><title_en><![CDATA[]]></title_en><user_id>869820</user_id><user_firstLast_name>Dora Lastovčić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-6365</code><acronim><![CDATA[]]></acronim><duration>27.04.2026 - 27.07.2026</duration><status>U tijeku</status><financ_value>7.820,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet kemijskog inženjerstva i tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Chemical Engineering and Technology]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>18985</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Karlo Kobeščak]]></title_hr><title_en><![CDATA[]]></title_en><user_id>869558</user_id><user_firstLast_name>Karlo Kobeščak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-3141</code><acronim><![CDATA[]]></acronim><duration>16.03.2026 - 24.07.2026</duration><status>U tijeku</status><financ_value>11.135,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>18986</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Sabina Špoljar]]></title_hr><title_en><![CDATA[]]></title_en><user_id>869746</user_id><user_firstLast_name>Sabina Špoljar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-6500</code><acronim><![CDATA[]]></acronim><duration>01.04.2026 - 29.06.2026</duration><status>U tijeku</status><financ_value>7.650,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut za fiziku]]></institution_hr><institution_en><![CDATA[Institute of Physics in Zagreb]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>18988</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Franko Pahović]]></title_hr><title_en><![CDATA[]]></title_en><user_id>871145</user_id><user_firstLast_name>Franko Pahović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-5429</code><acronim><![CDATA[]]></acronim><duration>16.03.2026 - 30.07.2026</duration><status>U tijeku</status><financ_value>11.645,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>18995</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Sara Vaing]]></title_hr><title_en><![CDATA[]]></title_en><user_id>873086</user_id><user_firstLast_name>Sara Vaing</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-5754</code><acronim><![CDATA[]]></acronim><duration>01.04.2026 - 30.06.2026</duration><status>U tijeku</status><financ_value>7.735,00 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Građevinarstvo, </scie_field_hr><scie_field_en>Civil engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Građevinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Civil Engineering]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>19010</id><title_hr><![CDATA[Odlazna mobilnost asistenata - Nikola Metličić]]></title_hr><title_en><![CDATA[]]></title_en><user_id>869842</user_id><user_firstLast_name>Nikola Metličić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>MOBDOK</proposal_type><proposal_call>2023</proposal_call><code>MOBDOK-2023-8816</code><acronim><![CDATA[]]></acronim><duration>01.05.2026 - 31.07.2026</duration><status>U tijeku</status><financ_value>7.820,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Geofizika, </scie_field_hr><scie_field_en>Geophysics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Science]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>100001</id><title_hr><![CDATA[Napredna integracija obnovljivih izvora]]></title_hr><title_en><![CDATA[]]></title_en><user_id>0</user_id><user_firstLast_name>Hrvoje Pandžić</user_firstLast_name><svouser_id>0</svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>PAR</proposal_type><proposal_call>2015-02</proposal_call><code>PAR-2015-02-4</code><acronim><![CDATA[SIREN]]></acronim><duration>01.12.2015 - 30.11.2018</duration><status>Završio</status><financ_value>131.225,70 eur</financ_value><scie_area_hr></scie_area_hr><scie_area_en></scie_area_en><scie_field_hr>, </scie_field_hr><scie_field_en>, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[Igor Kuzle, Ante Marušić, Tomislav Tomiša, Juraj Havelka, Ivan Rajšl, Kristina Jurković, Zoran Kovač, Miroslav Mesić, Tomislav Plavšić, Dubravko Sabolić, Igor Ivanković, Antun Andrić, Tin Bobetko, Krešimir Mesić, Ivan Pavičić, Renata Rubeša, Ivan Šturlić, Tonči Tadin, Ljupko Teklić, Vladimir Valentić, Zoran Zbunjak]]></team_members_names><keywords_hr><![CDATA[pogon sustava, vjetroelektrane, spremnici energije, sigurnost, fleksibilnost]]></keywords_hr><keywords_en><![CDATA[system operation, wind power, storage, security, flexibility]]></keywords_en><summary_hr><![CDATA[Integracija proizvodnih kapaciteta iz obnovljivih izvora energije (prvenstveno vjetra), čija je proizvodnja nestalna, teško predvidiva i brzo promjenjiva, predstavlja veliki izazov za operatora prijenosnog sustava. U Hrvatskoj je Hrvatski operator prijenosnog sustava (HOPS) dužan prihvatiti svu električnu energiju proizvedenu iz obnovljivih izvora, bez obzira na vrijeme i količinu proizvodnje. Navedena dužnost dodatno otežava pogon hrvatskog prijenosnog sustava: značajno su povećani zahtjevi na fleksibilnost sustava,potrebno je unaprijediti metode za upravljanje zagušenjima, te je potrebno analizirati i ažurirati procedure za planiranje i pogon sustava. Jedan dio projekta bit će usmjeren na prilagođavanje trenutnih i razvoj novih strategija upravljanja prijenosnom mrežom HOPS-a. Razmotrit će se značajke pogona vjetroelektrana u priobalju RH te njihovaočekivana proizvodnja i utjecaj nesigurnih parametara na pogon sustava. Izvršit će se ocjena dostatnosti kapaciteta prijenosne mreže i proizvodnih jedinica u svrhu određivanja zahtjeva fleksibilnosti u raznimpogonskim točkama. Predmetni zahtjevi će se ustanoviti za pojedine etape integracije obnovljivih izvora. U drugom će se dijelu projekta razmotriti potencijal spremnika energije u prijenosnoj mreži. Osim konvencionalnih spremnika poput reverzibilnih hidroelektrana, razmatrat će se primjena baterijskih spremnika energije i zamašnjaka. Navedeni spremnici mogu se koristiti za izravnavanje dnevnogdijagrama opterećenja, spremanje električne energije proizvedene iz vjetroelektrana, korektivne radnje nakon ispada elementa mreže, naponsku stabilnost te odgodu investicija u prijenosne vodove iproizvodne jedinice. Odredit će se cijene baterija i zamašnjaka pri kojima su investicije u navedene spremnike ekonomski opravdane. Također će se istražiti postojeći i predložiti novi regulatorni okviri za integraciju spremnika energije u prijenosnu mrežu.]]></summary_hr><summary_en><![CDATA[Large-scale integration of uncertain and intermittent renewable sources, such as wind, is a major challenge for system operators. In Croatia, the transmission system operator (HOPS) is obliged to accept the entire output of renewable generators, regardless of the time and quantity of the generated electricity. This imposition presents a large stress to the operation of the Croatian transmission system: the flexibility requirements are much higher, the congestion management needs to be refined and the system planning and operation procedures need to be updated.One part of the project will be directed to updating the current and developing new strategies of HOPS’s system operation practices. Wind power plants’ characteristics, their expected output and effects of uncertainty will be examined. Both transmission system and generating units’ adequacy will be assessed in order to determine the flexibility requirements at different operating states of the system. This will be done for different levels of wind integration. Another part of the project will investigate the benefits of energy storage units in transmission system. Besides the potential for construction of conventional storage units, i.e. pumped hydro power plants, the potential for utilization of battery energy storage and flywheels will be assessed as well. The usage of these storage units for arbitrage, storing energy from wind power plants, corrective actions after a contingency, voltage support, and deferment of investments in transmission lines and generators will be investigated. A price of storage at which this kind of installations become economically viable will bedetermined. Also, regulatory aspects of large-scale integration of storage will be investigated and proposed.]]></summary_en></project><project>
<id>100002</id><title_hr><![CDATA[Hrvatsko oftamološko nazivlje]]></title_hr><title_en><![CDATA[]]></title_en><user_id>0</user_id><user_firstLast_name>Mladen Bušić</user_firstLast_name><svouser_id>0</svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>STR</proposal_type><proposal_call>2016-05</proposal_call><code>STR-2016-05-1</code><acronim><![CDATA[HON]]></acronim><duration>01.09.2016 - 28.02.2018</duration><status>Završio</status><financ_value>11.982,22 eur</financ_value><scie_area_hr></scie_area_hr><scie_area_en></scie_area_en><scie_field_hr>, </scie_field_hr><scie_field_en>, </scie_field_en><institution_hr><![CDATA[Klinička bolnica „Sveti duh“]]></institution_hr><institution_en><![CDATA[]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[Mirjana Bjeloš, Daliborka Miletić, Josipa Bračić, Perina Vukša Nahod, Bruno Nahod]]></team_members_names><keywords_hr><![CDATA[oftamologija, nazivlje]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[ Temeljno, usustavljeno oftalmološko nazivlje bit će javno objavljeno u sklopu mrežne stranice Strune, što će omogućiti jednostavno pretraživanje kako stručnjacima oftalmolozima, tako i široj javnosti. Time će se osigurati nužni preduvjet za uporabu preporučenih naziva u radovima s oftalmološkom tematikom te sveučilišnim udžbenicima.]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>100003</id><title_hr><![CDATA[Izgradnja hrvatskoga drvnotehnološkog nazivlja]]></title_hr><title_en><![CDATA[]]></title_en><user_id>0</user_id><user_firstLast_name>Vlatka Jirouš-Rajković</user_firstLast_name><svouser_id>0</svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>STR</proposal_type><proposal_call>2016-05</proposal_call><code>STR-2016-05-2</code><acronim><![CDATA[DRVNA ]]></acronim><duration>02.10.2016 - 30.09.2017</duration><status>Završio</status><financ_value>9.384,70 eur</financ_value><scie_area_hr></scie_area_hr><scie_area_en></scie_area_en><scie_field_hr>, </scie_field_hr><scie_field_en>, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Šumarski fakultet]]></institution_hr><institution_en><![CDATA[]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[Boris Ljuljka, Ivica Grbac, Ružica Beljo Lučić, Hrvoje Turkulin, Vladimir Jambreković, Jelena Trajković, Stjepan Pervan, Mladen Brezović, Anka Ozvana Čavlović, Silvana Prekrat, Goran Mihulja, Zoran Vlaović, Ivica Župčić, Vjekoslav Živković, Marin Hasan, Josip Ištvanić, Alan Antonović, Danijela Domljan, Bogoslav Šefc, Miljenko Klarić, Nikola Španić, Tomislav Sedlar, Josip Miklečić, Matija Jug, Branimir Šafran, Kristina Klarić, Ivana Perić, Barbara Štebih Golub, Siniša Runjajuć]]></team_members_names><keywords_hr><![CDATA[drvna tehnologija, nazivlje]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Kontinuirano razvijanje drvnotehnološkog nazivlja. Rezultati projekta obogatit će višedisciplinarnu terminološki bazu drvnotehnološkim nazivljem te pomoći pri prevoođenju normi za drvo i drvne proizvode.]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>100004</id><title_hr><![CDATA[Genetički leksikon]]></title_hr><title_en><![CDATA[]]></title_en><user_id>0</user_id><user_firstLast_name>Mirjana Pavlica</user_firstLast_name><svouser_id>0</svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>STR</proposal_type><proposal_call>2016-05</proposal_call><code>STR-2016-05-4</code><acronim><![CDATA[GENETIKON ]]></acronim><duration>01.10.2016 - 31.03.2018</duration><status>Završio</status><financ_value>9.954,21 eur</financ_value><scie_area_hr></scie_area_hr><scie_area_en></scie_area_en><scie_field_hr>, </scie_field_hr><scie_field_en>, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[Bernardina Petrović, Petra Korać, Ana Vraneša, Krešimir Sučević Međeral ]]></team_members_names><keywords_hr><![CDATA[biologija, nazivlje]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Leksik područja molekularne i stanične biologije te omogućuje da na jednom mjestu budu okupljeni najvažniji pojmovi i sustavno razrađen riječnik ovoga dijela biološke struke na hrvatskome jeziku.]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>100005</id><title_hr><![CDATA[Hrvatsko farmakološko nazivlje]]></title_hr><title_en><![CDATA[]]></title_en><user_id>0</user_id><user_firstLast_name>Kristina Peroš</user_firstLast_name><svouser_id>0</svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>STR</proposal_type><proposal_call>2016-05</proposal_call><code>STR-2016-05-3</code><acronim><![CDATA[FARMANA]]></acronim><duration>01.09.2016 - 30.11.2017</duration><status>Završio</status><financ_value>9.476,41 eur</financ_value><scie_area_hr></scie_area_hr><scie_area_en></scie_area_en><scie_field_hr>, </scie_field_hr><scie_field_en>, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Stomatološki fakultet]]></institution_hr><institution_en><![CDATA[]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[Vlasta Bradamante, Igor Francetić, Alenka Boban Blagaić, Ileana Linčir, Kata Rošin-Grget, Vlaho Brailo, Marina Smolić, Robert Likić, Ivana Šutej, Eva Klarić, Lea Vuletić, Krešimir Bašić, Maja Valić, Petra Turčić, Katarina Vučić, Ivana Brač, Ivana Oraić Rabušić]]></team_members_names><keywords_hr><![CDATA[farmakologija, nazivlje ]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Osnovni zadatak projekta FARMANA je izradba baze podataka u kojoj će biti sabrani pojmovi iz farmakologije, njihovi nazivi na hrvatskom jeziku i stranim jezicima, s definicijama i drugim važnim podacima. Temelj baze su, uz struku, terminološka načela kojima se određuje valjanost ustaljenih i novih naziva. ]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>100006</id><title_hr><![CDATA[Pojmovnik antičke arheologije-stručna terminologija iz arheologije antičkoga razdoblja]]></title_hr><title_en><![CDATA[]]></title_en><user_id>0</user_id><user_firstLast_name>Domagoj Tončinić</user_firstLast_name><svouser_id>0</svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>STR</proposal_type><proposal_call>2016-05</proposal_call><code>STR-2016-05-5</code><acronim><![CDATA[POANTA ]]></acronim><duration>01.09.2016 - 28.02.2018</duration><status>Završio</status><financ_value>12.794,48 eur</financ_value><scie_area_hr></scie_area_hr><scie_area_en></scie_area_en><scie_field_hr>, </scie_field_hr><scie_field_en>, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[Mirjana Sanader, Marina Milićević Bradač, Zrinka Šimić Kanaet, Sanja Ivčević, Tomislav Šeparović, Zrinka Buljević, Iva Kaić, Vinka Bubić, Ivana Brač, Tomislava Bošnjak Botica ]]></team_members_names><keywords_hr><![CDATA[arhelogija, nazivlje ]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Cilj projektnog prijedloga je uspostava i obrada 1500 pojmova iz antičke arheologije te usklađivanje nazivlja. Provedba ovog projekta pridonijela bi stvaranju norme u hrvatskoj stručnoj terminologiji za granu antičke arheologije, što bi predstavljalo i nastavak projekta Hrvatske zaklade za znanost "Od stijene do riječi - izgradnja hrvatskog strukovnog nazivlja za kameno doba". Na taj bi se način izbjegao sadašnji problem da se u stručnoj literaturi koja se koristi u antičkoj arheologiji za iste pojmove rabe višestruki nazivi, a da pritom niti ti postojeći nazivi nisu dovoljno jasno definirani i da se koriste na različitim mjestima i s različitim značenjima. ]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>100007</id><title_hr><![CDATA[Hrvatsko kemijsko i laboratorijsko nazivlje]]></title_hr><title_en><![CDATA[]]></title_en><user_id>0</user_id><user_firstLast_name>Lidija  Varga-Defterdarović</user_firstLast_name><svouser_id>0</svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>STR</proposal_type><proposal_call>2016-05</proposal_call><code>STR-2016-05-6</code><acronim><![CDATA[KELANA ]]></acronim><duration>01.09.2016 - 30.11.2017</duration><status>Završio</status><financ_value>7.393,99 eur</financ_value><scie_area_hr></scie_area_hr><scie_area_en></scie_area_en><scie_field_hr>, </scie_field_hr><scie_field_en>, </scie_field_en><institution_hr><![CDATA[Institut Ruđer Bošković]]></institution_hr><institution_en><![CDATA[]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[Hrvoje Vančik, Tajana Preočanin, Željka Soldin, Vesna Petrović Peroković, Senka Djaković, Jasmina Lapić, Tomislav Portada, Siniša Runjajić, Ines Virč]]></team_members_names><keywords_hr><![CDATA[kemija, n azivlje ]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Pregledom osnovnoškolskih, srednjoškolskih i sveučilišnih udžbenika, te stručnih i znanstvenih članaka objavljenih na hrvatskom jeziku, uočena je ne samo neujednačenost hrvatskoga kemijskog nazivlja, već i neujednačenost hrvatskih naziva vezanih uz provedbu eksperimentalnog rada u laboratorijima, ali i rada u, danas malobrojnim, kemijskim pogonima. Kroz razgovor sa srednjoškolskim i sveučilišnim profesorima uočena je praznina u baratanju učenika i studenata hrvatskim kemijskim nazivima i nazivima laboratorijske opreme. U velikom broju slučajeva, što zbog nepoznavanja terminoloških načela, što zbog nedostatka volje za tvorbom i uporabom hrvatskih naziva, za veliki broj sitne i krupne opreme kemijskih laboratorija i pogona u uporabi su nazivi koji su neodgovarajuće izvedenice naziva iz engleskog ili njemačkog jezika. Pored toga, veći broj hrvatskih kemijskih naziva u svakodnevnoj uporabi ima normativni status žargonizma.  Kako bi se u što većoj mjeri uklonile gore navedene nedosljednosti uzrokovane nepostojanjem terminološke baze sa što većim brojem strukovno i terminološki usustavljenih pojmova iz kemije, sastavljen je projektni prijedlog Hrvatsko kemijsko i laboratorijsko nazivlje (KELANA).]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>100008</id><title_hr><![CDATA[Arheološki krajolik u održivom razvoju kulturnog turizma Općine Vrsar ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>0</user_id><user_firstLast_name>Robert Matijašić</user_firstLast_name><svouser_id>0</svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>PAR</proposal_type><proposal_call>2017-02</proposal_call><code>PAR-2017-02-2</code><acronim><![CDATA[ArchaeoCulTour]]></acronim><duration>15.01.2018 - 14.01.2021</duration><status>Završio</status><financ_value>199.084,21 eur</financ_value><scie_area_hr></scie_area_hr><scie_area_en></scie_area_en><scie_field_hr>, </scie_field_hr><scie_field_en>, </scie_field_en><institution_hr><![CDATA[Sveučilište Jurja Dobrile u Puli]]></institution_hr><institution_en><![CDATA[]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[Davor Bulić, Kristina Afrić Rakitovac, Nataša Urošević, Giovanni Boschian, Sara Popović, Marko Uhač, Katarina Šprem, Vlasta Gortan, Josip Višnjić, Tina Slamar, Sanda Bravar, Anton Prekalj, Ivan Gerometta, Mauricio Matukina, Roberto Gergeta, Milorad Harašić, Antonio Ciceran, Petra Pifar, Katarina Gerometta, Nikola Vojnović, Dolores Matika]]></team_members_names><keywords_hr><![CDATA[arheologija, krajolik, turizam, kulturna baština, prapovijest, antika, srednji vijek]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Ideja projektnog prijedloga polazi od prikupljanja, analize i sistematizacije podataka oarheološkim nalazištima na području Općine Vrsar, te njihove primjene u izradi planova irazradi koncepta razvoja kulturnog turizma na području Općine. Ciljevi obuhvaćajuidentifikaciju i analizu arheološke baštine na temelju do sada poznatih podataka, terenskihistraživanja (pregled terena i sondiranje odabranih lokaliteta), analize kartografije, zračnihsnimaka u dostupnim i primjenjivim tehnikama i formatima; utvrđivanje očuvanostikvalitete arheološkog zapisa s određivanjem prezentacijskog i istraživačkog potencijalanalazišta; očuvanje arheološke baštine i krajolika što će se primijeniti u izradi sustavakontinuiranog monitoringa; valorizacija arheološke baštine u kontekstu gospodarskograzvoja; istraživanje stavova lokalnog stanovništva, stručne javnosti i turista o kulturnoj,posebno arheološkoj baštini; primjena rezultata istraživanja u diseminaciji rezultata radijačanja svijesti o kulturnom turizmu kroz osmišljavanje novih načina predstavljanjabaštine; priprema odabranih lokaliteta za prezentaciju.Predviđene istraživačke metode polaze od klasičnih arheoloških tehnika identifikacije,istraživanja i valorizacije arheoloških nalazišta (pregled terena, sondiranje, analizaarheološkog materijala), suvremenih arheoloških tehnika (korištenje zračnih fotografija,mogućnosti koje pruža geoarheologija), a obuhvaćaju korištenje suvremenih informacijskihalata (GIS), prospekcijskih tehnologija (LIDAR), kao i anketiranje i analizu stavovajavnosti o arheološkoj baštini i njezinoj važnosti u razvoju kulturnog turizma.]]></summary_hr><summary_en><![CDATA[The idea of the project proposal is based on the collection, analysis and systematization ofdata on archaeological sites in the Municipality of Vrsar, and their use in making plans anddeveloping the concept of cultural tourism development in the Municipality. Its objectivesinclude the identification and analysis of archaeological heritage on the basis of known data,field research (field survey and probing of selected sites), analysis of cartography, aerialphotographs in available and applicable techniques and formats; the determination of thequality of preservation of the archaeological record with the definition of the presentation andresearch potential of single sites; the preservation of archaeological heritage and landscapethat will be used in the conception of a system of continuous monitoring; the valorisation ofarchaeological heritage in the economic development context; the implementation of opinionsurvey among local residents, professionals and tourists on cultural, in particulararchaeological heritage; the application of research results in the dissemination of the resultsfor the purpose of raising awareness of cultural tourism through the creation of new ways ofpresenting heritage; the preparation of selected sites for presentation.The envisaged research methods are based on the classic archaeological techniques ofidentification, investigation and evaluation of archaeological sites (overview of the terrain,probing, analysis of archaeological material), modern archaeological techniques (use of aerialphotographs, the opportunities provided by geoarchaeology), and include the use of moderninformation tools (GIS), prospection technologies (LIDAR), as well as the opinion survey andanalysis of public attitudes on archaeological heritage and its importance in the development ofcultural tourism.]]></summary_en></project><project>
<id>100009</id><title_hr><![CDATA[Integracija vjetroelektrana u elektroenergetski sustav sa smanjenom tromosti]]></title_hr><title_en><![CDATA[]]></title_en><user_id>0</user_id><user_firstLast_name>Igor Kuzle </user_firstLast_name><svouser_id>0</svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>PAR</proposal_type><proposal_call>2017-02</proposal_call><code>PAR-2017-02-3</code><acronim><![CDATA[WINDLIPS]]></acronim><duration>01.01.2018 - 31.12.2020</duration><status>Završio</status><financ_value>159.267,37 eur</financ_value><scie_area_hr></scie_area_hr><scie_area_en></scie_area_en><scie_field_hr>, </scie_field_hr><scie_field_en>, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[Igor Kuzle, Nenad Debrecin, Tomislav T omiša, Davor Grgić, Perica Ilak, Mateo Beus, Matej Krpan, Goran Grdenić, Igor Ivanković, Miroslav Mesić, Antun Andrić, Renata Rubeša, Goran Levačić, Boris Avramović, Kristijan Frlan, Ivan Tolić, Nenad Švarc, Marko Špoljarić, Tomislav Robina]]></team_members_names><keywords_hr><![CDATA[Wind energy generation, ancillary services, renewable energy
integration, frequency regulation, inertia constant, wind power plant]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Povećanje broja vjetroelektrana (VE) s generatorima s varijabilnombrzinom vrtnje u sustavu i fotonaponskih (FN) elektrana kojezamjenjuju konvencionalne sinkrone proizvodne jedinice ima zaposljedicu smanjenje konstante tromosti elektroenergetskogsustava (EES) zbog čega se smanjuje i stabilnost sustava naporemećaje radne snage (ispad proizvodnje ili potrošnje).Projekt će biti usmjeren na istraživanje mogućnosti obnovljivihizvora energije (OlE) za pružanje incijalnog inercijskog odziva ipomoćnih usluga sustava, te razvoj regulatornih i tehničkih okvirakoji omogućavaju takvo djelovanje.U prvom dijelu projekta identificirat će se trenutne dinamičkeznačajke hrvatskog EES-a, udio i vrste pojedinih elektrana teutjecaj postojećih OlE na konstantu tromosti i ostale pogonskeznačajke sustava uz kritičku analizu postojećih koncepataupravljanja odzivom VE. Analizirat će se strategije razvoja EES-aHrvatske i planirani novi proizvodni kapaciteti iz OIE, te će se natemelju toga predvidjeti njegove buduće dinamičke značajke .Opisat će se tipovi izvedbe vjetroagregata te zahtjevi pogonadefinirani mrežnim pravilima. Analizirat će se tehnički zahtjevimrežnih pravila za priključenje OlE u zemljama jugoistočne Europe.U drugom dijelu projekta, težište istraživanja bit će na primjeni VEza potporu stabilnosti frekvencije sustava pomoću upravljanjanjihovim inercijskim odzivom i djelatnom snagom u kratkomvremenskom periodu nakon nastanka poremećaja . Predložit će seodgovarajući načini upravljanja VE kojim će se omogućiti da sevjetroagregati tijekom početne, prijelazne faze frekvencijskogodziva EES-a vladaju približno kao klasični turboagregati kako bi sezadržale slične dinamičke karakteristike frekvencijskog odziva EESaneovisno o stupnju integracije VE. Detaljno će se analiziratiprimarna regulacija frekvencije EES-a i dinam i čke značajke odzivasustava pri poremećajima u postojećim uvjetima i uvjetimapovećane inteqraciie VE u EES.]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>100010</id><title_hr><![CDATA[Hrvatsko knjižničarsko nazivlje]]></title_hr><title_en><![CDATA[]]></title_en><user_id>0</user_id><user_firstLast_name>Daniela Živković</user_firstLast_name><svouser_id>0</svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>STR</proposal_type><proposal_call>2017-09</proposal_call><code>STR-2017-09-1</code><acronim><![CDATA[Biblion ]]></acronim><duration>28.02.2018 - 28.08.2019</duration><status>Završio</status><financ_value>10.089,59 eur</financ_value><scie_area_hr></scie_area_hr><scie_area_en></scie_area_en><scie_field_hr>, </scie_field_hr><scie_field_en>, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[Sanja Brbora, Rajka Gjurković Govorčin, Aleksandra Horvat, JelicaLeščić, Dijana Machala, Marina Mihalić, Breza Šalamon- Cindori, Maja Živko]]></team_members_names><keywords_hr><![CDATA[knjižničarstvo, rječnik]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Predloženi projekt Hrvatsko knjižničarsko nazivlje – BIBLION predviđa usustavljivanje knjižničarskog nazivlja i  obradu oko 1500 temeljnih naziva iz različitih segmenata knjižničarstva. Temeljni je cilj projekta izgradnja sustava hrvatskoga knjižničarskog nazivlja,  što bi u konačnici trebalo rezultirati e-rječnikom knjižničarskoga nazivlja, odnosno zbirkom knjižničarskog nazivlja unutar šire Strunine terminološke baze. Time bi se pridonijelo boljoj i preciznijoj komunikaciji unutar knjižničarske struke, ali i sporazumijevanju između srodnih struka, olakšao bi se nastavni proces, prevođenje stručne literature, te istodobno knjižničarsko nazivlje približilo zainteresiranoj javnosti. Uvelike bi se olakšao posao uredništva stručnog časopisa i stručnih izdanja koja, pri procjenjivanju o objavi pojedinog teksta, vode računa i o korištenju odgovarajućeg stručnog nazivlja. Knjižničarska je struka jedna od najizloženijih novoj informacijsko-komunikacijskoj tehnologiji i zato je stalno prisiljena usvajati novo nazivlje, a često ga i odgovarajuće prilagoditi domaćim prilikama i uvjetima. Zato je ovaj projekt prilika da se postojeće nazivlje osuvremeni i stvori novo u konzultaciji s jezikoslovcima uzimajući u obzir dosadašnje terminološke aktivnosti.]]></summary_hr><summary_en><![CDATA[-]]></summary_en></project><project>
<id>100011</id><title_hr><![CDATA[Forenzično-kriminalističko nazivlje]]></title_hr><title_en><![CDATA[]]></title_en><user_id>0</user_id><user_firstLast_name>Željana Bašić</user_firstLast_name><svouser_id>0</svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>STR</proposal_type><proposal_call>2017-09</proposal_call><code>STR-2017-09-2</code><acronim><![CDATA[FuNK]]></acronim><duration>20.02.2018 - 20.08.2019</duration><status>Završio</status><financ_value>7.379,39 eur</financ_value><scie_area_hr></scie_area_hr><scie_area_en></scie_area_en><scie_field_hr>, </scie_field_hr><scie_field_en>, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Sveučilišni odjel za forenzične znanosti]]></institution_hr><institution_en><![CDATA[]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[Ivana Kružić, Šimun Anđelinović, Dragan Primorac, Mitchell M. Holland, Timothy Palmbach, J. D., Katarina Vilović, Slobodan Marendić, Kristijan Bečić, Gorana Rosandić, Ante Lozina, Josip Crnjac, Ana Banovac, Ivan Jerković, Toni Ljubić]]></team_members_names><keywords_hr><![CDATA[Forenzičke znanosti, kriminalistika, istraživanje mjesta događaja, tragovi, forenzična antropologija, balistika, entomologija, identifikacija]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[-]]></summary_hr><summary_en><![CDATA[-]]></summary_en></project><project>
<id>100012</id><title_hr><![CDATA[Izgradnja hrvatskog računovodstvenog nazivlja]]></title_hr><title_en><![CDATA[]]></title_en><user_id>0</user_id><user_firstLast_name>Ivana Mamić Sačer </user_firstLast_name><svouser_id>0</svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>STR</proposal_type><proposal_call>2017-09</proposal_call><code>STR-2017-09-3</code><acronim><![CDATA[HRANA]]></acronim><duration>26.02.2018 - 25.02.2019</duration><status>Završio</status><financ_value>12.333,27 eur</financ_value><scie_area_hr></scie_area_hr><scie_area_en></scie_area_en><scie_field_hr>, </scie_field_hr><scie_field_en>, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Ekonomski fakultet]]></institution_hr><institution_en><![CDATA[]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[Lajoš Žager, Katarina Žager, Boris Tušek, Sanja Sever Mališ, Ivana Pavić, Nikolina Dečman, Ana Novak, Ana Ježovita, Mateja Brozović, Ana Rep, Matea Filko]]></team_members_names><keywords_hr><![CDATA[Računovodstvo, Međunarodni standardi financijskog izvještavanja, Hrvatski standardi, financijskog izvještavanja, računovodstvena direktiva Europske unije, temeljni financijski izvještaji, hrvatsko računovodstveno nazivlje]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[-]]></summary_hr><summary_en><![CDATA[-]]></summary_en></project><project>
<id>100013</id><title_hr><![CDATA[Pojmovnik klasične arhitektrue]]></title_hr><title_en><![CDATA[]]></title_en><user_id>0</user_id><user_firstLast_name>Ana Šverko</user_firstLast_name><svouser_id>0</svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>STR</proposal_type><proposal_call>2017-09</proposal_call><code>STR-2017-09-4</code><acronim><![CDATA[KLAS]]></acronim><duration>26.02.2018 - 26.08.2019</duration><status>Završio</status><financ_value>10.800,98 eur</financ_value><scie_area_hr></scie_area_hr><scie_area_en></scie_area_en><scie_field_hr>, </scie_field_hr><scie_field_en>, </scie_field_en><institution_hr><![CDATA[Institut za povijest umjetnosti]]></institution_hr><institution_en><![CDATA[]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[Josip Belamarić, Nataša Jakšić, Goran Nikšić, Karin Šerman, Danko Zelić, Iva Raič Stojanović]]></team_members_names><keywords_hr><![CDATA[antika, renesansa, barok, klasicizam, neostilovi, klasična razdoblja, arhitektura, krajobrazna arhitektura, urbanizam, arhitektonske tipologije, gradbene tehnike, arhitektonski elementi, dekorativni elemanti, ornamenti]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[-]]></summary_hr><summary_en><![CDATA[-]]></summary_en></project><project>
<id>100014</id><title_hr><![CDATA[Hrvatsko jezikoslovno nazivlje]]></title_hr><title_en><![CDATA[]]></title_en><user_id>0</user_id><user_firstLast_name>Milica Mihaljević </user_firstLast_name><svouser_id>0</svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>STR</proposal_type><proposal_call>2017-09</proposal_call><code>STR-2017-09-5</code><acronim><![CDATA[JENA]]></acronim><duration>26.02.2018 - 26.08.2019</duration><status>Završio</status><financ_value>9.954,21 eur</financ_value><scie_area_hr></scie_area_hr><scie_area_en></scie_area_en><scie_field_hr>, </scie_field_hr><scie_field_en>, </scie_field_en><institution_hr><![CDATA[institut za hrvatski jezik i jezikoslovlje]]></institution_hr><institution_en><![CDATA[]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[Branimir Belaj, Matea Birtić, Goranka Blagus Bartolec, Tomislava Bošnjak Botica, Ivana Barač, Ankica Čilaš Šimpraga, Marijana Horvat, Lana Hudaček, Jozić Željko, Barbara Kovačević, Kristian Lewis, Ivana Matas Ivanković, Milan Mihaljević, Ana Ostroški Anić, Mateusz Milan Stanojević, Barbara Štebih Golub, Kristina Štrkalj Despot, Perina Vukša Nahod]]></team_members_names><keywords_hr><![CDATA[nazivlje, hrvatski jezik, generativna gramatika, kognitivna lingvistika, leksikologija, gramatika, pravopis, onomastika, dijalektologija, frazeologija, povijest jezika]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[-]]></summary_hr><summary_en><![CDATA[-]]></summary_en></project><project>
<id>100015</id><title_hr><![CDATA[Modulatori katalitičkog mehanizma gama-sekretaze kao novi potencijalni lijekovi za Alzheimerovu bolest]]></title_hr><title_en><![CDATA[]]></title_en><user_id>0</user_id><user_firstLast_name>Željko Svedružić</user_firstLast_name><svouser_id>0</svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>PAR</proposal_type><proposal_call>2015-02</proposal_call><code>PAR-2015-02-1</code><acronim><![CDATA[AlzheimerModulation]]></acronim><duration>15.10.2015 - 14.10.2017</duration><status>Prekinut</status><financ_value>84.258,15 eur</financ_value><scie_area_hr></scie_area_hr><scie_area_en></scie_area_en><scie_field_hr>, </scie_field_hr><scie_field_en>, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Odjel za biotehnologiju]]></institution_hr><institution_en><![CDATA[]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[Anja Harej, Om Goel]]></team_members_names><keywords_hr><![CDATA[Alzheimerova bolest, razvoj novih lijekova, analize strukture i funkcije molekula, neurodegeneracija, protein-ligand vezanja, neuroznanost, bioloska kemija, SAR studije]]></keywords_hr><keywords_en><![CDATA[Neurodegeneration, drug development, structure activity relationship]]></keywords_en><summary_hr><![CDATA[Značaj: U posljednjih 15 godina bilo je više od stotinu neuspješnih strategija u razvoj lijekova za Alzheimerovu bolest. Takav veliki broj neočekivanih neuspjeha je duboko potresao povjerenje farmaceutske industrije u današnje metode za razvoj lijekova za Alzheimerovu bolest.Pozadina: Alzheimerova bolest se obično pripisuje promjenama u metabolizmu amiloid prekursor proteina (APP), specifično promjenama u aktivnosti membranske proteaze γ-sekretaze te pripadnim netopljivim Aβ produktima. Velika većina lijekova u razvoju koji ciljaju γ-sekretazu pokazuju vrlo neobične dvofazne aktivacijske-inhibicijske dozne krivulje pri fiziološkim koncentracijama supstrata. Teško je očekivati da se novi lijekovi mogu razviti iz spojeva koji mogu zbog nepoznatih razloga aktivirati i inhibirati ciljni enzim. Stoga, problem dvofazne inhibicije γ-sekretaze mora biti riješen.Metode: Predstavljamo jedinstvene studije strukture i aktivnost (SAR) dvofaznih inhibitora koje mogu premostiti nedostatke u industrijskim visokoprotočnim metodama. Za razliku od industrijskih metoda koje za razvoj novih lijekova koriste umjetno visoke koncentracije supstrata, mi sva naša mjerenja počinjemo s fiziološkim koncentracijama supstrata. Zatim postepeno simuliramo patogeno povećanje metabolizma APP proteina kako bi promatrali pripadne promjene u aktivnosti γ-sekretaze i dvofaznoj inhibiciji.Preliminarni rezultati potvrđuju valjanost predloženih pristupa.Očekivani rezultat: Različiti lijekovi u razvoju će se razdvojiti prema mehanizmu djelovanja i prema afinitetu vezanja na aktivirajuće i inhibirajuće mjesto na γ-sekretazi. Dobiveni rezultati će se koristiti u SAR istraživanjima kako bi se dizajnirali novi spojevi koji mogu selektivno poticati stvaranje netoksičnih Aβ-produkata i smanjiti stvaranje toksičnih Aβ produkata. Kompetitivni inhibitori će se izdvojiti od nekompetitivnih inhibitora kako bi se smanjila inhibicija fizioloških funkcija γ-sekretaze i popratne toksične nuspojave.]]></summary_hr><summary_en><![CDATA[Significance: In the last 15 years more than a hundred of different therapeutic approaches for Alzheimer’s disease have failed. Such large number of unsettling failures has deeply shaken confidence of pharmaceutical industry in the current drug development strategies.Background: Alzheimer’s disease is usually attributed to changes in metabolism of Amyloid precursor protein (APP), specifically to the activity of a membrane-embedded protease γ-secretase and its insoluble Aβ products. The majority of drug-candidates that target γ-secretase show very unusual biphasic activation-inhibition dose-response curves at physiological substrate concentration. It is hard to expect that effective drug-candidates can be developed from compounds that can for unknown reasons both activate and inhibit γ-secretase. Thus, the problem of biphasic inhibition must be solved.Methods: We present unique structure-activity relationship (SAR) studies of the biphasic inhibition that can surpass deficiencies in the industrial high-throughput screenings. In difference to industrial screening that use artificially high substrate concentrations, we start all our measurements of biphasic inhibition at physiological sub-saturating substrate concentrations. Then, we gradually simulate pathogenic increase in APP metabolism to analyze the corresponding changes in γ-secretase activity and the biphasic inhibition. The validity of the presented approaches is demonstrated with some preliminary results.Expected outcome: Different drug candidates will be separated based on the mechanism of action and the binding affinity for activation and inhibition sites on γ-secretase. Then, SAR studies will be used to design novel compounds that can selectively favor production of non-toxic Aβ products relatively to the toxic Aβ-products. Competitive inhibitors will be separated from noncompetitive inhibitors to minimize the toxic side-effects caused by inhibition of other physiological functions of γ-secretase]]></summary_en></project><project>
<id>100016</id><title_hr><![CDATA[Karbonilacija proteina u zdravom starenju i bolestima povezanima sa starenjem]]></title_hr><title_en><![CDATA[]]></title_en><user_id>0</user_id><user_firstLast_name>Ozren Polašek</user_firstLast_name><svouser_id>0</svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>PAR</proposal_type><proposal_call>2016-05</proposal_call><code>PAR-2016-05-5</code><acronim><![CDATA[CarboNyx]]></acronim><duration>01.06.2017 - 31.05.2020</duration><status>Završio</status><financ_value>159.267,37 eur</financ_value><scie_area_hr></scie_area_hr><scie_area_en></scie_area_en><scie_field_hr>, </scie_field_hr><scie_field_en>, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[Ivana Kolčić, Ajka Relja, Ana Miljković, Francois-Xavier Pellay, Romain Ladouce, Marina Konta, Željka Majić, Sandra Raić]]></team_members_names><keywords_hr><![CDATA[Starenje, karbonilacija, biomarker, genetika, predviđanje]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[Cilj ovog projekta je istražiti ulogu oksidacije (karbonilacije) proteina u starenju i otkriti nove biomarkere normalnog i ubrzanog starenja kod ljudi. Projekt će biti proveden u sklopu kohorte 10,001 Dalmatinac, koja je jedan od najboljih istraživačkih resursa u području biomedicine u Hrvatskoj. Projektni plan uključuje mjerenje više od tisuću raznih proteina i njihove karbonilacije korištenjem dvo-dimenzionalnog gela kod 200 zdravih predodabranih ispitanika te kod 200 ispitanika s poznatim bolestima koje su povezane s dobi, koji su svi prethodno bili genotipizirani ili sekvencirani. Uz to, razvit ćemo i stanične linije fibroblasta u podskupini istih ispitanika, što će nam omogućiti razumijevanje patofizioloških mehanizama reakcije kože na vanjske stresne utjecaje. Korištenje izolirane populacije koja se nalazi u sličnim okoličnim uvjetima će olakšati razumijevanje mehanizama starenja, dok će dostupnost opsežnih kliničkih, fenotipskih mjerenja i genetičke informacije omogućiti razvoj izuzetnog resursa za istraživanje starenja. Nakon završetka projekt CarboNyx imat će mogućnost stvaranja vrhunskih istraživačkih rezultata kao i razvoj novih biomarkera koji će biti zanimljivi za industrijsku upotrebu u zdravlju i ljepoti. Voditelj projekta je međunarodno prepoznati istraživač u genetičkoj epidemiologiji, s opsežnim iskustvom u vođenju projekata i izvrsnim znanstvenim rezultatima u prethodnih deset godina te opsežnom potporom ustanove, što će imati pozitivan učinak na završetak projekta. Sinergija s MEDILS-om, vodećom privatnom istraživačkom ustanovom u području starenja omogućit će ne samo primjenu novih rezultata, nego će i stvoriti odličan primjer vrlo traženih partnerstava između javnih i privatnih ustanova u znanosti u Hrvatskoj.]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>100017</id><title_hr><![CDATA[Manipuliranje imunološkom memorijom Razvoj novih strategija u svrhu stvaranja boljeg memorijskog CD8 T-staničnog odgovora protiv COVID-19 nakon cijepljenja ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>0</user_id><user_firstLast_name>Felix Wensveen</user_firstLast_name><svouser_id>0</svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP-CORONA</proposal_type><proposal_call>2020-04</proposal_call><code>IP-CORONA-2020-04-2045</code><acronim><![CDATA[CORONAWAI]]></acronim><duration>15.07.2020 - 14.01.2022</duration><status>Završio</status><financ_value>164.791,96 eur</financ_value><scie_area_hr></scie_area_hr><scie_area_en></scie_area_en><scie_field_hr>, </scie_field_hr><scie_field_en>, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[Đurđica Cekinović Grbeša, Marija Livajić, Inga Kavazović, Mia Krapić, Sali Slavić Stupac,Jan Koster, Paul Klarenbeek,  Bojan Polić, Klaas van Gisbergen]]></team_members_names><keywords_hr><![CDATA[CD8 T cell memory, vaccine, scope of protection, COVID-19 ]]></keywords_hr><keywords_en><![CDATA[CD8 T cell memory, vaccine, scope of protection, COVID-19 ]]></keywords_en><summary_hr><![CDATA[Pandemija COVID-19 pokazala je koliko smo još uvijek osjetljivi na virusne infekcije. Najbolji način zaštite našeg društva od ovakvih opasnosti je putem razvoja sigurnih i učinkovitih cjepiva koja će osigurati dugotrajnu imunost. Da bismo to mogli učiniti za SARS-Cov-2 (SARS2), virus koji uzrokuje COVID-19, moramo istražiti kako naš imunološki sustav reagira na ovu bolest. Osim toga, znamo da SARS2 mutira dok se širi globalnom populacijom. Stoga trebamo razumjeti ako nas imunitet formiran protiv SARS2 štiti samo od izvornog patogena ili je u mogućnosti zaštiti nas i od potencijalnih mutanta ovog virusa. Drugim riječima, trebamo odrediti opseg imunološke memorije, odnosno njegovu zaštitnu sposobnost tj. potencijal. Ako naš imunološki sustav može prepoznati samo vrlo mali broj virusnih inačica, trebali bismo modificirati cjepiva na način da povećamo njihov zaštitni potencijal. Moramo osigurati da nas cjepivo ne štiti samo od SARS2, nego i od njegovih mutanti.U ovom projektu izolirat ćemo krv od COVID-19 pacijenata koji su preboljeli bolest, tj. uzorke ćemo prikupiti tri mjeseca nakon što su izliječeni i kada je došlo do formiranja imunološke memorije. Iz krvi ovih pacijenata izolirat ćemo limfocite te okarakterizirati funkcionalna svojstva imunoloških stanica ('memorijskih limfocita’) koje posreduju imunitet protiv SARS2. Usporedit ćemo ove stanice s ostalim stanicama koje nas štite od drugih respiratornih virusa, primjerice gripe, kako bi ispitali sličnost njihovih funkcionalnih svojstava. U suradnji s našim partnerima u Nizozemskoj napravit ćemo analizu visoke-rezolucije glavnih molekula koje reguliraju zaštitna svojstva SARS2-specifičnih memorijskih stanica. Također, ispitat ćemo opseg imunološke memorije korištenjem naprednih imunoloških metoda. Naposljetku, koristit ćemo specifične mišje modele za oponašanje SARS2 infekcije. Važno je naglasiti da ćemo koristiti i novorazvijeni terapeutski pristup kako bi povećali zaštitnu sposobnost memorijskih stanica koje nas štite od ponovne infekcije. Pomoću navedenih modela pokazat ćemo da možemo povećati učinkovitost cjepiva usmjerenih protiv SARS2.  Ovaj projekt bit će proveden u sklopu Centra izvrsnosti za virusnu imunologiju i cjepiva u Rijeci te se temelji na desetljećima iskustva u proučavanju protuvirusnih memorijskih stanica. Osim toga, naša je grupa vodeća u svijetu u istraživanju opsega protuvirusne imunološke memorije. Stoga će ovaj projekt pružiti jedinstven i vrijedan doprinos globalnom naporu u borbi protiv pandemije COVID-19.]]></summary_hr><summary_en><![CDATA[The COVID-19 epidemic, caused by the SARS-CoV-2 virus, has made a devastating impact on the world.The loss of lives and health, the crash of the economy and the psychological stress of isolation anduncertainty affect our society in a way that has not been seen since the Spanish flu. Whereas antiviralmedication is being developed, the general consensus is that our best protection against SARS-CoV-2 isa new vaccine. A global effort is being undertaken to develop an agent to induce a broad neutralizingantibody response. Unfortunately, even when a vaccine has been developed, the scope of its protectivecapacity is uncertain. Many pathogens are poorly controlled by B cell mediated antibody responses andtherefore require strong T cell activation to prevent viral spread. It is therefore essential to develop avaccine that induces both a strong T and B cell response. In addition, RNA viruses can rapidly mutateand pathogens such as influenza therefore quickly develop escape mutants even when a vaccine iseffective. Variants of SARS-CoV-2 have already been isolated in the field and coronaviruses are known toundergo recombination events with other strains, thus adding to their variability. A vaccine for COVID-19 will only provide long-term protection if it induces immunological memory that is not onlydirected against the current version of SARS-CoV-2, but also against possible viral mutants. At themoment, methods to broaden the scope of vaccines are very limited.Our team has more than a decade of experience in studying the underlying molecular mechanisms thatcontrol antigen-driven selection of anti-viral T and B cells. Recently, in a HRZZ-financed project, wediscovered a key molecular mechanism that controls the scope of the memory CD8 T cell responseagainst intracellular pathogens during priming. We found that memory precursor cells of low-affinity arepreserved through induction of the pro-survival protein Bcl-2 by the transcription factor Eomes.Importantly, through pharmacological targeting of Bcl-2, we could narrow the scope of the CD8 memorypool, which reduced the capacity of animals to fight viral mutants. In this project, we will exploit thismechanism to broaden the scope of the human immune response against SARS-CoV-2. Its purposeis to generate a memory CD8 T cell pool that provides protection against many viral variants.We will isolate blood from COVID-19 patients, at least three months after they have been declared virusfree.Using a combination of rational design and experimental approaches, we will map viral epitopesthat induce a dominant memory CD8 T cell response. With functional assays, high-parameter flowcytometry combined with RNA sequencing techniques, we will map the characteristics of the SARS-CoV-2 specific memory CD8 T cell pool. By high-throughput T cell receptor sequencing, we will determine thediversity of the SARS-CoV-2 specific memory CD8 T cell pool. We will design altered peptide ligands of theimmuno-dominant epitopes of SARS-CoV-2, which will allow us to elucidate the scope of the memory CD8T cell pool on a functional level and compare it to other respiratory pathogens. Finally, we will developnew tools for the analysis of SARS-CoV-2 specific memory CD8 T cell formation in vivo. We will use theseto test the efficacy of a new pharmacological agent with which we will broaden the scope of the memoryCD8 T cell pool and provide enhanced protection against viral variants of SARS-CoV-2. In summary, wewill construct the tools that we need to generate a CD8 T cell vaccine against SARS-CoV-2 anddevelop means to improve upon its protective capacity.Our team combines international experts in the fields of anti-viral immunology, human infectious diseaseand advanced bio-informatic analysis methods. Our team has shown many times to be internationallycompetitive in the field of anti-viral CD8 T cell biology. We therefore believe that the project proposedhere is able to make a significant contribution to the global effort to develop an effective vaccineagainst one of the greatest acute threats to our society.]]></summary_en></project><project>
<id>100018</id><title_hr><![CDATA[Glikani kao biomarkeri i funkcionalni efektori teškog oblika COVID-19]]></title_hr><title_en><![CDATA[]]></title_en><user_id>0</user_id><user_firstLast_name>Gordan Lauc</user_firstLast_name><svouser_id>0</svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP-CORONA</proposal_type><proposal_call>2020-04</proposal_call><code>IP-CORONA-2020-04-2052</code><acronim><![CDATA[GlycoCOVID]]></acronim><duration>08.07.2020 - 07.01.2022</duration><status>Završio</status><financ_value>199.040,79 eur</financ_value><scie_area_hr></scie_area_hr><scie_area_en></scie_area_en><scie_field_hr>, </scie_field_hr><scie_field_en>, </scie_field_en><institution_hr><![CDATA[Genos]]></institution_hr><institution_en><![CDATA[]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[Mislav Novokmet, Maja Pučić Baković,Irena Trbojević Akmačić,Olga Gornik Kljaić, Frano Vučković, Marija Pezer, Olga Zaytseva, Jasmika Krištić, Thomas Klarić, Natali Nakić, Ivan Gudelj, Jerko Štambuk, Iwona Wojcik, Anne-Marie Patenaude, Helena Deriš, Tea Petrović, Ivica Lukšić, Jasminka Peršec, Alemka Markotić ]]></team_members_names><keywords_hr><![CDATA[Protein glycosylation, COVID-19, IgG glycosylation, Immune age ]]></keywords_hr><keywords_en><![CDATA[Protein glycosylation, COVID-19, IgG glycosylation, Immune age ]]></keywords_en><summary_hr><![CDATA[Glikani su složeni oligosaharidi vezani za proteine ​​i lipide koji reguliraju različite procese, uključujući i imuni sustav. Poznato je da su i SARS-CoV-2 i njegova glavna stanična meta ACE2 visoko glikozilirani. Razlike u glikanima predstavljaju jednu od glavnih mehanizama obrane svih viših organizama protiv patogena, a repertoar glikana također se mijenja s godinama, posebice u dobnim rasponima koji su najpodložniji teškim oblicima COVID-19. Međutim, zbog njihove strukturalne složenosti i tehničkih ograničenja za analizu, glikani do sada nisu bili uključeni niti u jedno veliko kliničko istraživanje COVID-19. Za ovaj projekt smo okupili multidisciplinarni tim sastavljen od istraživačke skupine u Genosu, koja je globalni lider u visokopropusnoj glikomici, i dvije vodeće kliničke istraživačke skupine za COVID-19 u Hrvatskoj. Znanstveni tim dodatno je ojačan suradnicima iz Italije, Španjolske i Portugala koji će osigurati dodatne uzorke i kliničke podatke bolesnika s COVID-19. Uzastupnom analizom ukupnih glikana u plazmi i IgG glikana tijekom razvoja bolesti kod najmanje tisuću pacijenata s blagim i teškim oblicima COVID-19 ostvarit ćemo tri glavna cilja: (1) Procijeniti glikozilaciju proteina domaćina kao prediktora težine COVID-19; (2) Utvrditi značaj biološke dobi kao prediktora težine COVID-19 i (3) Ispitati promjene u ukupnoj proteini i glikozilaciji IgG kao prediktore teškog oblika COVID-19.]]></summary_hr><summary_en><![CDATA[Glycans are complex oligosaccharides attached to proteins and lipids that regulate a variety of processes,including immunity. Both the SARS-CoV-2 virus and its principal cellular target ACE2 are known to be highlyglycosylated. Inter-individual diversity in glycans represents one of the main defences of all higher organismsagainst pathogens, and the repertoire of glycans also changes with age, especially in the age ranges that aremost susceptible to severe forms of COVID-19. In addition, glycans are one of regulators of antibody effectorfunctions and many other aspects of the immune system. However, due to their structural complexity andtechnical limitations for their analysis, glycans have so far not been included in any large clinical study ofCOVID-19. For this project we have assembled a multidisciplinary team composed of a research group inGenos, which is the global leader in high-throughput glycomics, and two leading clinical research groups forCOVID-19 in Croatia. This core team is further reinforced with collaborators from Spain, Portugal and Iranwho will provide additional samples and clinical data from COVID-19 patients, which makes us uniquelypositioned to perform this ambitious study.By analysing total plasma glycans and IgG glycans in multiple longitudinal samples of approximately 1000mild and severe COVID cases we will address three main objectives: (1) Evaluate host protein glycosylationas predictor of COVID-19 severity; (2) Evaluate biological age as predictor of COVID-19 severity and (3)Evaluate changes in total protein and IgG glycosylation as predictors of severe COVID-19.State of the art methods (UPLC-FLR and LC-MS) that are routinely being used in Genos for large clinical andepidemiological studies of the glycome will be used for glycan analysis. Experimental design, data preprocessingand statistical analysis will be performed by Genos data analysis team. Patient recruitment,sample collection, collection and interpretation of clinical data will be the responsibility of our clinicalpartners in national COVID-19 centre in University Hospital Dubrava and Infective Hospital “Dr. FranMihaljević” in Zagreb. Additional clinical samples and data will be provided by our foreign collaborators inSpain, Portugal, and Iran.As the new evidence is accumulating it becomes increasingly clear that the number of infected people is verylarge, and that severe cases and deaths are just a tip of an iceberg that is visible in this global pandemic. Thisindicates that severe form of COVID-19 is a very rare event that is probably caused/associated by some preexistingfactors. Old age and cardiometabolic diseases associate with severe COVID-19, but their incidence inpopulation is too high to be used as stratifiers. We believe that glycomic data can provide importantinformation about inter-individual differences at the molecular level that directly interacts with SARS-CoV-2.The ability to early identify people at high risk of severe COVID-19 would help guide therapeutic strategy andprovide important guidance for rational organisation of healthcare, which is of utmost importance in asituation of limited availability of resources.]]></summary_en></project><project>
<id>100019</id><title_hr><![CDATA[Determining the strain variability of the novel CoV-2 and underlying genetic predisposition of the host as a discovery tool for virulence and risk factors in COVID-19 pandemic]]></title_hr><title_en><![CDATA[]]></title_en><user_id>0</user_id><user_firstLast_name>Kristian Vlahoviček</user_firstLast_name><svouser_id>0</svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP-CORONA</proposal_type><proposal_call>2020-04</proposal_call><code>IP-CORONA-2020-04-2084</code><acronim><![CDATA[COV-HOST-SEQ]]></acronim><duration>15.07.2020 - 14.01.2022</duration><status>Završio</status><financ_value>199.084,01 eur</financ_value><scie_area_hr></scie_area_hr><scie_area_en></scie_area_en><scie_field_hr>, </scie_field_hr><scie_field_en>, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[Rosa Karlić, Maja Kuzman, Dunja Glavaš, Ana Livun, Marina Korolija, Josipa Skelin, Vjekoslav Tomaić, Gordana Maravić Vlahoviček, Tomislav Domazet-Lošo, Mirjana Domazet-Lošo, Robert Belužić, Ivan Šamija, Ivana Ćelap, Mario Štefanović, Sanja Tadinac, Lidija Cvetko Krajinović, Vladimir Krajinović, Željka Mačak Šafranko, Antonela Blažeković, Kristina Gotovac Jerčić, Danilo Licastro]]></team_members_names><keywords_hr><![CDATA[High throughput sequencing, genotyping, computational analysis, machine learning ]]></keywords_hr><keywords_en><![CDATA[High throughput sequencing, genotyping, computational analysis, machine learning ]]></keywords_en><summary_hr><![CDATA[Pandemija koronavirusa SARS-CoV-2 je duboko potresla i ostavila negativne posljedice na sve aspekte ljudskog društva, od medicinskih do socioekonomskih. Bolest COVID-19 koju ovaj virus uzrokuje poprima izuzetno širok raspon kliničkih simptoma, a u često nepredvidljivom tijeku bolesti mogući ishodi kreću se od potpuno asimptomatskog prebolijevanja pa sve do smrti često uzrokovane teškim akutnim zastojem respiratornog sustava. U ovome trenutku ne postoji djelotvorno cjepivo protiv virusa, kao ni ciljana medicinska terapija, pa se liječenje uglavnom svodi na ublažavanje simptoma. Iako su identificirane neke rizične skupine ljudi koje su češće zahvaćene težom kliničkom slikom, još uvijek nisu u potpunosti poznati svi čimbenici kojima bismo pouzdano mogli predvidjeti tijek i ishod bolesti. Upravo je mogućnost prepoznavanja, utvrđivanja i otklanjanja rizika ključna u uspješnom obuzdavanju pandemije i stoga je ovoj problematici posvećeno iznimno mnogo pozornosti u cjelokupnoj istraživačkoj zajednici. Predmet ovog istraživanja je ispitati postoji li povezanost između težine kliničkih simptoma i genetičke podloge pojedinaca oboljelih od bolesti COVID-19. Upotrebom najnovijih generacija tehnologije sekvenciranja genetičke informacije, utvrdit ćemo individualne genetičke slike do dvije stotine zaraženih pojedinaca, povezati ih s težinom i oblikom njihovih simptoma i utvrditi postoje li određene genetičke značajke koje bi mogle poslužiti kao pouzdan dijagnostički pokazatelj visokog rizika u razvoju težih oblika bolesti. Usporedno s time, odredit ćemo i zasebni genetički slijed virusa svake zaražene osobe, istražiti u kojoj su mjeri zastupljene mutacije virusne RNA unutar hrvatske populacije, pratiti brzinu i stopu kojom virus mutira, te ispitati kako na tijek bolesti utječe međuodnos virusnih mutacija i genetičke podloge pojedinca.Ovo istraživanje doista je interdisciplinarno. U njemu sudjeluje preko dvadeset istraživača iz tri kliničke bolnice – KB Dubrava, KBC Sestre Milosrdnice i Klinike za infektivne bolesti „Dr. Fran Mihaljević“, Instituta Ruđer Bošković, Centra za forenzična ispitivanja, istraživanja i vještačenja „Ivan Vučetić“, kao i predstavnici čak četiri sastavnice Sveučilišta u Zagrebu – Prirodoslovno-matematičkog fakulteta, Medicinskog fakulteta, Fakulteta elektrotehnike i računarstva i Farmaceutsko-biokemijskog fakulteta. Ovi istraživači i njihovi timovi spajaju nekoliko znanstvenih područja, od infektologije, epidemiologije i kliničke biokemije, preko genomike, molekularne i računalne biologije, do računarstva i podatkovnih znanosti. U projekt smo također uključili i međunarodne stručnjake iz talijanske regije Friuli Venezia Giulia kao i suradnike iz dijaspore s njemačkog Sveučilišta u Tübingenu. Upravo u ovakvom multidisciplinarnom pristupu, kroz prikupljanje velike količine medicinskih i genetičkih podataka, njihove analize i tumačenja, želimo pridonijeti boljem razumijevanju mogućih zdravstvenih rizika pojedinaca, tijeka bolesti i pouzdanijoj prognozi ishoda, a u konačnici pružiti globalni znanstveni doprinos usmjeren ka konačnom zaustavljanju pandemije novog koronavirusa.  ]]></summary_hr><summary_en><![CDATA[The novel coronavirus SARS-CoV-2 has caused a global spread of the Coronavirus disease COVID-19 resulting in a world pandemic and causing a global negative impact on all aspects of human society. The disease manifests itself with an astonishingly wide range of clinical symptoms and outcomes among the infected individuals, and presently neither specific vaccines nor targeted treatment of disease causes are available. With a very high variation among the symptom severity even outside the high-risk individuals, more information is needed on potential risk factors including the underlying genetic predisposition towards infection and disease progression. Combined with not fully investigated mutational potential of the SARS-CoV-2, these factors may play important roles in monitoring and diagnosing the disease spread and symptom progression, as well as provide meaningful inputs into the risk management and alleviation during the ongoing pandemic or any subsequent recurrences.The goal of this research is to leverage on the power of high-throughput sequencing of second and third generations in order to a) investigate the viral properties at the level of genetic information in order to assess its potential to mutate in a local microenvironment, and if so to identify the most affected loci, possibly associated with symptom severity, and b) to sample in parallel the genetic information of the infected human host in order to find possible associations between the symptom severity and genetic susceptibility of the infected patient. Since no viral sequences originating from Croatia are available yet, isolation and sequencing of viral genomes from Croatian patients will enable us to perform the first analysis of the genetic variability of viral genomes in Croatia. In addition, phylogenetic analysis and annotation of viral sequences with geographic locations will be used to infer migration events and draw conclusions about viral entries into the Croatian territory and their subsequent propagation. In addition, the analysis of viral phylogeny will enable us to infer potential virulence determinants, ie. mutations that contribute to virulence of SARS-CoV-2.We will also use a cost-effective whole exome sequencing approach to contribute towards the amassing data collected on SARS-CoV-2 infected patients. This would in turn contribute towards identification of potential SARS-CoV-2 susceptibility variants in COVID-19 patients and examine the potential contribution of host genetic factors to symptom severity and disease outcome. In the same context, we will also explore the potential contribution of host mtDNA single nucleotide variation. Since haplogroup-related variants, as well as both homoplasmic and heteroplasmic mutations influence regulation of oxidative phosphorylation, production of reactive oxygen species and apoptosis, repercussions of mtDNA genomic landscape on the intensity of the immune response due to viral infection are to be expected. To the extent of our knowledge, no such experiments are underway related to SARS-CoV-2 at the moment.Finally, based on our and other publicly available data, we will develop machine learning models to predict clinical outcomes based on viral and host traits, biochemical parameters, and information on treatments, comorbidities and other relevant patient characteristics. Predictive models developed as part of this analysis have the potential of facilitating informed treatment decisions for future patients. We plan to register our study as a part of the international COVID-19 host genetics initiative and share the results of our analyses of host variants identified in host whole-exome and mtDNA sequencing data with the rest of the global community. This will enable us to contribute to the ongoing effort with our datasets and compare the variants potentially related to COVID-19 susceptibility found in Croatian patients to those identified in other populations. Our ultimate aim is to contribute to global knowledge of the biology of SARS-CoV-2 infection and disease. Our huge potential spans from clinicians and molecular biology experts in three major Croatian clinical hospitals, to the leading experts in the field of genomics and computational biology ranging across the entire public research sector - the well renowned National Forensic Center, the most prominent Croatian research institute Rudjer Boskovic, as well as four constituents of the Zagreb University, the largest Croatian public higher education institution. Moreover, we have reached beyond the national borders and expanded our collaborative network within the region, by linking to the expertise and knowledge of the major Italian contributor to the information on SARS-CoV-2, the CBM of Friuli Venezia Giulia, who were the first to sequence the Italian strains of the virus. With a highly interdisciplinary approach involving clinicians, infectologists, epidemiologists, genomics experts and computational biologists, we will be able to tackle the proposed objectives very effectively and with high chance of success.]]></summary_en></project><project>
<id>100020</id><title_hr><![CDATA[Dosta skrivanja CoV-2: Uspostava baze monoklonskih protutijela na SARS-Cov-2 (No more hiding CoV-2: Establishment of SARS-Cov-2 mAbeom)]]></title_hr><title_en><![CDATA[]]></title_en><user_id>0</user_id><user_firstLast_name>Ilija Brizić</user_firstLast_name><svouser_id>0</svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP-CORONA</proposal_type><proposal_call>2020-04</proposal_call><code>IP-CORONA-2020-04-2073</code><acronim><![CDATA[CoV2mAbs]]></acronim><duration>08.07.2020 - 07.01.2022</duration><status>Završio</status><financ_value>198.931,32 eur</financ_value><scie_area_hr></scie_area_hr><scie_area_en></scie_area_en><scie_field_hr>, </scie_field_hr><scie_field_en>, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[Tihana Lenac Roviš, Paola Kučan Brlić, Ivana Stražić Geljić, Ljerka Karleuša, Carmen Rožmanić, Fran Krstanović, Andrea Mihalić, Karmela Miklić, Suzana Malić, Alemka Markotić ]]></team_members_names><keywords_hr><![CDATA[Monoclonal antibodies; proteome; SARS-CoV-2; COVID-20]]></keywords_hr><keywords_en><![CDATA[Monoclonal antibodies; proteome; SARS-CoV-2; COVID-20]]></keywords_en><summary_hr><![CDATA[Nakon pojave bolesti COVID-19 i otkrića njezinog uzročnika, virusa SARS-CoV-2, velik dio znanstvene zajednice orijentirao se na istraživanje ove bolesti, te je u vrlo kratkom vremenu generirano jako puno znanja o ovome virusu. Međutim, daljnja temeljna i primijenjena istraživanja zahtijevaju razvoj novih istraživačkih alata. Monoklonska protutijela su jedan od najvažnijih istraživačkih alata u području biomedicinskih znanosti čije tržište kontinuirano raste. Cilj je ovog projekta razviti monoklonska protutijela na sve proteine virusa SARS-CoV-2. U tu svrhu ćemo: 1) proizvesti sve proteine virusa SARS-CoV-2 primjenom rekombinante tehnologije, 2) razviti monoklonska protutijela na cjelokupni proteom SARS-CoV-2 virusa (29 proteina), 3) primijeniti razvijena protutijela u istraživanjima biologije i patogeneze SARS-CoV-2 virusa. Unutar ovog projekta surađivat ćemo sa nekoliko inozemnih i domaćih partnerskih institucija (Institut Heinrich-Pette, Hamburg, Njemačka;  Medicinsko sveučilište Beč, Austrija; Izraelski institut tehnologije (Technion), Haifa, Izrael; Hebrejsko Sveučilište u Jeruzalemu, Izrael; Klinika za infektivne bolesti Fran Mihaljević, Zagreb). Monoklonska protutijela ćemo koristiti u istraživanjima koja imaju za cilj razjasniti temeljnu biologiju ovog virusa i mehanizme nastanka bolesti. S obzirom da područje istraživanja SARS-CoV-2 virusa rapidno raste, razvoj seta monoklonskih protutijela koji prepoznaju proteine SARS-CoV-2 omogućit će pokrivanje širokog spektra trenutnih i budućih potreba znanstvene zajednice što bi u konačnici moglo značajno pridonijeti razumijevanju ovog virusa i bolesti. Uz suradnju s već navedenim institucijama, razvoj monoklonskih protutijela omogućit će nam uspostavu novih suradničkih projekata i potencijalno komercijalizaciju rezultata projekta. U Centru za proteomiku Medicinskog fakulteta u Rijeci, gdje će se projekt provoditi, do sada je razvijeno nekoliko stotina monoklonskih protutijela, od čega je velik dio specifičan za virusne proteine (VZV, citomegalovirus i drugi). Ove aktivnosti omogućile su suradnju sa brojnim institucijama u svijetu, kao i prijenos znanja u industriju. Stoga, s obzirom na iskustvo koje posjedujemo ovo je projekt niskog rizika, a donijet će veliku korist. Uz to, pridonijet će pozicioniranju Sveučilišta i hrvatske znanosti kao relevantne u međunarodnoj zajednici u području istraživanja bolesti COVID-19. ]]></summary_hr><summary_en><![CDATA[In late December of 2019, the coronavirus disease (COVID-19) caused by severe acute respiratory syndrome CoV-2 (SARS-CoV-2) was identified in Wuhan (China). Since then, SARS-CoV-2 has been declared as public health emergency, quickly spread all over the world and pandemic of SARS-CoV-2 was declared on March 11th 2020 by the World Health Organization (WHO). Basic and applied research of SARS-CoV-2 biology and pathogenesis is of utmost need. Many academic and industry laboratories worldwide have employed their capacities to deal with SARS-CoV-2, resulting in major gain of knowledge in only a few months. However, further progress and understanding of SARS-CoV-2 will heavily depend on development of research tools. Monoclonal antibodies are an essential tool in most life science studies, widely used in both diagnostics and therapy. Our goal is to develop monoclonal antibodies for all of SARS-CoV-2 proteins. To that aim we will: 1) Express all SARS-CoV-2 proteins (whole proteome, 29 proteins) using eukaryotic and/or prokaryotic expression system; 2) Produce monoclonal antibodies to all SARS-CoV-2 proteins (produce SARS-CoV-2 mAbeom); 3. Validate monoclonal antibodies and implement them into research of SARS-CoV-2. To achieve these goals we will team up with several national and international research groups working on complementary research. Since the research of SARS-CoV-2 is rapidly expanding, existence of these antibodies will enable to meet emerging needs of scientific community all over the world. Importantly, development of such tools has a huge potential to significantly enhance the ability of scientific community to study basic biology of the virus, but also to join global scientific efforts to cope with the pandemic. Therefore, the ultimate goal of this project proposal is to establish a bank of monoclonal antibodies that could meet the current and future needs of scientific community, with the end-result of major impact on SARS-CoV-2 research. We are strongly convinced that this project is a perfect fit for the Croatian Science Foundation special call on SARS-CoV-2, as it will have broad and instant impact on the SARS-CoV-2 research. Besides being a high gain, this is a low-risk project. Our department, Center for Proteomics (part of the Center of Excellence in Viral Immunology and Vaccines), is the prime site for the development of monoclonal antibodies in the region and beyond. During the last 14 years we have developed hundreds of monoclonal antibodies, many of which are specific for viral proteins. In addition, the Center for Proteomics has extensive experience in developing antibodies used in commercial diagnostic kits, as well as patented and licensed for immunotherapy. Therefore, our aim to produce monoclonal antibodies against all SARS-CoV-2 proteins is highly achievable. As a direct proof of principle, monoclonal antibodies against almost the entire Varicella Zoster Virus proteome were developed at the Center for Proteomics – 59 in total. Finally, these efforts will strenghten the capacity of our university and Croatian science in general and position us among the leaders in SARS-CoV-2 research. ]]></summary_en></project><project>
<id>100021</id><title_hr><![CDATA[Atenuirani β-herpesvirus sa snažnim imunomodulatornim kapacitetom kao vektorsko cjepivo protiv SARS-CoV-2]]></title_hr><title_en><![CDATA[]]></title_en><user_id>0</user_id><user_firstLast_name>Astrid Krmpotić</user_firstLast_name><svouser_id>0</svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP-CORONA</proposal_type><proposal_call>2020-04</proposal_call><code>IP-CORONA-2020-04-2055</code><acronim><![CDATA[HerpVecCoV]]></acronim><duration>08.07.2020 - 07.01.2022</duration><status>Završio</status><financ_value>199.082,75 eur</financ_value><scie_area_hr></scie_area_hr><scie_area_en></scie_area_en><scie_field_hr>, </scie_field_hr><scie_field_en>, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[Maja Cokarić Brdovčak, Irena Slavuljica, Lea Hiršl, Mijo Golemac, Tina Jenuš, Marko Šustić, Mihaela Kordun]]></team_members_names><keywords_hr><![CDATA[Cytomegalovirus, vaccine vector, SARS-CoV-2, CD8 T lymphocytes, NKG2D]]></keywords_hr><keywords_en><![CDATA[Cytomegalovirus, vaccine vector, SARS-CoV-2, CD8 T lymphocytes, NKG2D]]></keywords_en><summary_hr><![CDATA[Virus SARS-CoV-2 pojavio se u Kini krajem 2019. godine te se brzo proširio, i dalje se širi, diljem svijeta te trenutno predstavlja glavni svjetski javnozdravstveni problem. Lijeka za SARS-CoV-2 još nema i razvoj učinkovitog cjepiva je od velike važnosti. Do sada objavljeni rezultati istraživanja imunološkog odgovora na SARS-CoV-2 ukazuju da su, uz protutijela, limfociti T, osobito oni u dišnom sustavu, važni u imunološkoj kontroli SARS-CoV-2, te uz to pružaju dugotrajnu zaštitu. Također je pokazano da su strukturni proteini koronavirusa, posebice S i N, koji sadrže brojne B i T-stanične epitope, najimunogeničniji. Humani citomegalovirus (HCMV) je β-herpesvirus koji je široko rasprostranjen među ljudima, ali je infekcija kod imunokompetentnih osoba najčešće asimptomatska. Infekcija CMV-om inducira odgovor CD8 limfocita T u procesu koji se naziva “memorijska inflacija” – CD8 limfociti T specifični za pojedine virusne epitope u latentnoj fazi infekcije kontinuirano se ekspandiraju i konačno postižu visoku frekvenciju funkcionalnih stanica sa karakteristikama efektorskih limfocita T. Ove stanice posebno su prisutne u sluznicama što je važno za kontrolu patogena na mjestu njihovog ulaska u organizam. CMV su razvili brojne mehanizme izbjegavanja imunološkog nadzora domaćina i naša grupa ove mehanizme istražuje godinama. Temeljeno na rezultatima koje smo dobili proučavajući rekombinantne viruse kojima nedostaju pojedini imunosubverzivni geni, dizajnirali smo vektorsko cjepivo bazirano na CMV-u. Konstruirali smo rekombinantni mišji citomegalovirus (MCMV) u kojem je gen za RAE-1γ, ligand za aktivacijski imuni receptor NKG2D, ubačen u virusni genom na mjesto njegovog virusnog inhibitora m152 (RAE-1γMCMV). RAE-1γMCMV je jako atenuiran, ali potiče snažan protektivni odgovor limfocita T i protutijela. Zatim smo konstruirali vektorska cjepiva bazirana na RAE-1γMCMV koja izražavaju pojedine strane epitope (npr. imunodominantni CD8 epitop L. monocytogenes) i pokazali da imunizacija ovim vektorom štiti domaćina od infekcije patogenom čiji epitop vektor nosi. Stoga je glavni cilj ovog projekta konstruirati rekombinantne RAE-1γMCMV koji izražavaju strukturne proteine S, M ili N od SARS-CoV-2 te ispitati njihov potencijal kao vektorskih cjepiva za SARS-CoV-2. Očekujemo da će ova eksperimentalna vektorska cjepiva protiv SARS-CoV-2 inducirati snažan protektivan i dugotrajan odgovor limfocita T i protutijela koji će miševe štititi od infekcije sa SARS-CoV-2. Također očekujemo da će se dobiveni rezultati i stečena znanja moći translatirati te doprinijeti dizajniranju HCMV vektorskih cjepiva koja izražavaju ULBP2 (ligand za NKG2D kod ljudi) i strukturne proteine SARS-CoV-2, a koja će imati potencijal induciranja snažnog i dugotrajnog imunološkog odgovora koji će štititi ljude od SARS-CoV-2 infekcije.                ]]></summary_hr><summary_en><![CDATA[Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in China at the end of 2019. It causes coronavirus disease 2019 (COVID-19) ranging in symptoms from very mild to severe, including pneumonitis, acute respiratory distress syndrome (ARDS), respiratory failure, and potentially death. Currently, the SARS-CoV-2 epidemic is still rapidly spreading worldwide and is a major public health issue, but an effective antiviral treatment has not been identified. Thus, there is an urgent need to develop an effective vaccine against SARS-CoV-2. Although little is known about immune responses against SARS-CoV-2, data published so far indicate that in addition to antibody response, T cells, especially those residing in the respiratory tract, are important for SARS-CoV-2 immune control providing long-term protection. Studies on other coronaviruses indicate that viral structural proteins, with many B cell and T cell epitopes, are the most immunogenic. Among structural proteins, T cell responses against the S and N proteins have been reported to be the most dominant and long-lasting. Human cytomegalovirus (HCMV) is β-herpesvirus that is universally present in the human population, but infection is usually asymptomatic in immunocompetent individuals. CMV infection induces a unique CD8 T cell response in a process known as "memory inflation". Namely, CD8 T cells specific for certain viral epitopes continue to expand in the latent phase of CMV infection and eventually stabilize at high frequencies of functional effector-like cells. Moreover, CMV-specific CD8 T cells are biased toward mucosal tissue distribution, which could be particularly relevant for the control of pathogens directly at their sites of entry. CMVs develop many immunoevasion mechanisms to avoid host’s immune control and our group has been studied these mechanisms for years. Based on the data obtained on immunology of recombinant viruses lacking immunoevasion genes, we have designed recombinant CMV-based vaccine vectors. We constructed recombinant mouse CMV (MCMV) in which RAE-1γ, a ligand of activating immune receptor NKG2D, was inserted into the MCMV genome in place of its viral inhibitor m152 (RAE-1γMCMV). RAE-1γMCMV is highly attenuated but at the same time is able to generate highly protective both antibody and T cell response. We have also generated RAE1γMCMV-based vectors expressing foreign epitopes (e.g. immunodominant CD8 T cell epitope of L. monocytogenes) and confirmed that the expression of the NKG2D ligand RAE-1γ by an MCMV vector bearing a foreign CD8 T cell epitope considerably increased the magnitude and effector functions of the CD8 T cell response. Moreover, our preliminary data indicate that RAE1γMCMV-based vector expressing influenza hemagglutinin protects mice against Influenza virus.Altogether, our data provide a strong evidence that CMV expressing cellular ligand for NKG2D receptor represents an excellent vaccine vector against emerging pathogens, such as SACS-CoV-2. Therefore, the major goal of the project proposal is to generate recombinant RAE-1γMCMVs expressing S, M or N structural proteins of SARS-CoV-2 and to investigate their vaccine potential. We will analyze not only SARS-CoV-2-specific antibodies and T cell response in mice immunized with MCMV-based vectors expressing NKG2D ligand and SARS-CoV-2 structural proteins, but also capacity of these vaccine vectors to contain SARS-CoV-2 infection in a way to limit its spread within tissue and prevent overwhelming immunopathology.We expect that our experimental vaccine vector against SARS-CoV-2 will induce highly protective, long-lasting specific T cell and antibody response that will effectively protect animals from challenge infection with SARS-CoV-2. The obtained results and the acquired knowledge may be translated and contribute to the design of HCMV vector expressing ULBP2, a human ligand of the NKG2D receptor, and SARS-CoV-2 structural proteins with a potential to induce a broad and long-lasting immunity in humans. Since CMV is already known to be able to re-infect the seropositive host, we expect the vaccine to be effective not only in seronegative but also in seropositive subjects.]]></summary_en></project><project>
<id>100022</id><title_hr><![CDATA[Stvaranje preduvjeta za uvođenje SARS-CoV-2 seroterapije u Hrvatskoj]]></title_hr><title_en><![CDATA[]]></title_en><user_id>0</user_id><user_firstLast_name>Beata Halassy</user_firstLast_name><svouser_id>0</svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP-CORONA</proposal_type><proposal_call>2020-04</proposal_call><code>IP-CORONA-2020-04-2053</code><acronim><![CDATA[CoVIg]]></acronim><duration>15.07.2020 - 14.01.2022</duration><status>Završio</status><financ_value>199.074,26 eur</financ_value><scie_area_hr></scie_area_hr><scie_area_en></scie_area_en><scie_field_hr>, </scie_field_hr><scie_field_en>, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Centar za istraživanje i prijenos znanja u biotehnologiji]]></institution_hr><institution_en><![CDATA[]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[Irena Jukić, Marija Brgles, Tihana Kurtović, Ana Hećimović, Tomislav Vuk, Oktavija Rode, Tanja Košutić Gulija, Adela Štimac, Maja Lang Balija, Sanda Ravlić, Sanja Mateljak Lukačević, Ana Vučenović Mijatović, Mirna Tominac, Josipa Ćakarun Miletić, Iva Lugović, Anja Britvec Generalić, Dina Rnjak, Ozren Jakšić, Ena Sorić]]></team_members_names><keywords_hr><![CDATA[SARS-CoV-2 neutralising antibody, COVID-19 convalescent plasma, SARSCoV-2 specific serotherapy, immunoglobulin downstream processing ]]></keywords_hr><keywords_en><![CDATA[SARS-CoV-2 neutralising antibody, COVID-19 convalescent plasma, SARSCoV-2 specific serotherapy, immunoglobulin downstream processing ]]></keywords_en><summary_hr><![CDATA[Pasivna imunoterapija jest oblik liječenja oboljelih primjenom antitijela prikupljenih od osoba koje su preboljele patogenom uzrokovanu bolest ili su protiv nje cijepljene. Specifični imunoglobulini humanog (ali i animalnog) porijekla imaju važnu ulogu u liječenju različitih kliničkih stanja, uključujući i virusne bolesti (hepatitis A i B, bjesnoća, vodene kozice, ospice, infekcije uzrokovane respiratornim sincicijskim virusom, citomegalovirusom). U situacijama iznenadnih infekcija i pandemija, jedan od načina borbe protiv patogena jest liječenje pacijenata plazmom prikupljenom od onih koji su se s bolešću uspješno izborili. Cijeli svijet, pa tako i Hrvatska, suočili su se s COVID-19 pandemijom, koju uzrokuje još do nedavno nepoznati SARS-CoV-2 virus. Iskustva iz ranijih proboja drugih koronavirusa (SARS-CoV-1) govore da su serumi ozdravljenih sadržavali antitijela specifična za relevantni virus, i da je prijenos takvih seruma u oboljele pospješivao njihovo liječenje. Prerada plazme u pripravke visoko-pročišćenih imunoglobulina je poželjna, jer su u odnosu na plazmu takvi oblici lijekova sigurniji i imaju jaču neutralizacijsku aktivnostOvim projektom ćemo stvoriti preduvjete za razvoj seroterapije za COVID-19 bolest u Hrvatskoj, kroz realizaciju tri temeljna projektna cilja: (1) organizaciju prikupljanja plazme ljudi koji su od COVID-19 bolesti ozdravili, njezino testiranje i adekvatnu pohranu; (2) uspostavu metodologije za pouzdanu procjenu sposobnosti prikupljenih antitijela da neutraliziraju SARS-CoV-2 virus; (3) razvoj učinkovitog i održivog procesa izolacije čistih imunoglobulina iz humane plazme na laboratorijskoj skali, koji bi bio pogodan za hitne i krizne situacije. Prvi cilj uključuje organizaciju etičkih i infrastrukturnih pretpostavki za uspostavu nacionalne banke plazme specifične za SARS-CoV-2 virus, koja će biti dobro karakterizirana i provjereno bez prisutnosti virusa. Svakom uzorku plazme biti će izmjerena sposobnost neutralizacije virusa. Drugi cilj uključuje uspostavu uzgoja virusa SARS-CoV-2 u kulturi stanica, razvoj metodologije za određivanje količine infektivnog virusa i za određivanje sposobnosti plazme/antitijela da taj virus neutraliziraju. Uspostavljena metodologija će predstavljati osnovu svih budućih istraživanja djelotvornosti novih lijekova i cjepiva protiv ovog virusa. Treći cilj uključuje pripravu prototipa za SARS-CoV-2 specifični imunoglobulin koji ispunjava regulatorne zahtjeve kvalitete za ovaj tip lijeka. Namjera je razviti proizvodni proces njegove priprave na laboratorijskoj skali, te uspostaviti i optimirati metode za kontrolu njegove kvalitete, a koje bi zainteresirane kompanije i institucije mogle lako prenijeti u fazu razvoja lijeka za humanu primjenu.   Projekt će realizirati znanstvenici i stručnjaci iz četiri hrvatske institucije - Centra za istraživanje i prijenos znanja u biotehnologiji Sveučilišta u Zagrebu, Hrvatskog zavoda za transfuzijsku medicinu, Klinike za infektivne bolesti „Dr. Fran Mihaljević“ i Imunološkog zavoda.]]></summary_hr><summary_en><![CDATA[Passive immunotherapy is a century-old practice of administering antibodies from exposed convalescentsor vaccinated persons to patients susceptible to the disease in question. Specific immunoglobulins, some evenfrom animal sources, have an important role in the treatment of various clinical conditions, including viraldiseases (hepatitis A and B, rabies, varicella, infections with respiratory syncytial virus, cytomegalovirus,measles). In situations where vaccines are not available, such as during emerging infections and pandemics(infuenza, SARS-CoV-1, MERS, Ebola), convalescent plasma is being collected from donors who haverecovered from the disease, and used to treat different pathogens. The whole world, including Croatia, is facingCOVID-19 pandemics induced by so far unknown virus named SARS-CoV-2. Experience from prior outbreakswith other coronaviruses (SARS-CoV-1) shows that such convalescent sera contain neutralising antibodiesagainst relevant virus, and that their use was beneficial in the treated patients.1,2 Therapy with antibody-ladenblood of those who have survived an infection has nowadays been considered worldwide.3 Convalescentplasma therapy carries also some risks, but using modern blood-banking technologies these risks are rare andoutweighed by the benefits. Production of highly purified immunoglobulin preparation containing a high titer ofneutralizing antibodies against SARS-CoV-2 is preferable to convalescent plasma given that these are saferand have higher activity.The aim of this project is three-fold: (1) to develop and organize COVID-19 convalescent plasma collection,testing and storage in Croatia; (2) to establish relevant methodology to properly estimate SARS-CoV-2neutralization capacity of both convalescent plasma and purified specific immunoglobulins (CoVIg); (3) todevelop an efficient and sustainable process for isolation of immunoglobulins from human hyperimmune(convalescent) plasma in emerging situations at a laboratory scale.Aim (1) includes organization of ethical and infrastructural issues for preparation of national COVID-19 convalescent plasma bank, properly characterized according to regulatory requirements and screenedfor the absence of SARS-CoV-2 nucleic acid. In addition, neutralization potency of each plasma sampletowards SARS-CoV-2 will be determined by cell-culture based neutralization assay.Aim (2) includes development of relevant methodology for establishment of reproducible SARSCoV-2 cultivation and laboratory reference preparation, infective virus quantification, and estimationof antibody neutralization power against SARS-CoV-2. The developed assay for measurement of functionalantibodies will be compared to other assays available and used for SARS-CoV-2 specific antibody detectionto estimate their relevance and accuracy in seropositivity determination. Established methodology will bereproducible and precise and might become the basis for future research towards novel therapeutics andvaccines.Aim (3) includes preparation of the prototype product of SARS-CoV-2 specific immunoglobulin thatfulfils regulatory demands for existing hyperimmune immunoglobulins, considering particularly protein content,aggregate content, molecular size distribution, potency and purity. The aim is to validate virus inactivationpower of critical process steps. The process parameters and methods established and optimized will bereadily transferable to the product developmental phase of interested companies and institutions.]]></summary_en></project><project>
<id>100023</id><title_hr><![CDATA[Inhibitori koronavirusnih makrodomena – novi pristup liječenju bolesti uzrokovane koronavirusima]]></title_hr><title_en><![CDATA[]]></title_en><user_id>0</user_id><user_firstLast_name>Andreja Mikoč</user_firstLast_name><svouser_id>0</svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP-CORONA</proposal_type><proposal_call>2020-04</proposal_call><code>IP-CORONA-2020-04-2041</code><acronim><![CDATA[CoVMacI]]></acronim><duration>15.07.2020 - 14.01.2022</duration><status>Završio</status><financ_value>125.423,05 eur</financ_value><scie_area_hr></scie_area_hr><scie_area_en></scie_area_en><scie_field_hr>, </scie_field_hr><scie_field_en>, </scie_field_en><institution_hr><![CDATA[Institut Ruđer Bošković]]></institution_hr><institution_en><![CDATA[]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[Petra Mikolčević, Andrea Hloušek-Kasun, Ivan Ahel, Sumana Sanyal]]></team_members_names><keywords_hr><![CDATA[Coronavirus, SARS-CoV-2, ADP-ribosylation, macrodomain, macrodomain inhibitor ]]></keywords_hr><keywords_en><![CDATA[Coronavirus, SARS-CoV-2, ADP-ribosylation, macrodomain, macrodomain inhibitor ]]></keywords_en><summary_hr><![CDATA[U okviru ovog projekta pokušat ćemo onesposobiti mehanizam koji su koronavirusi razvili kako bi izbjegli antivirusni odgovor domaćina. Naš fokus će biti na posttranslacijskoj modifikaciji ADP-ribozilaciji koja ima važnu ulogu u antivirusnom odgovoru. Enzimi koji sudjeluju u procesu ADP-ribozilacije prenose ADP-ribozu na različite ciljne proteine što dovodi do aktivacije imunološkog sustava domaćina i inhibicije virusne replikacije. Svi koronavirusi sadrže evolucijski očuvanu proteinsku domenu zvanu makrodomena koja može ukloniti ADP-ribozu s modificiranih proteina i tako poništiti učinak antivirusne ADP-ribozilacije. Makrodomene koronavirusa ključne su za patogenezu virusa jer potiču replikaciju virusa i suzbijaju imunološki odgovor domaćina te su kao takve obećavajuća meta antivirusnih lijekova. Inhibicija koronavirusnih makrodomena pomoću malih molekula postala je novi terapeutski pristup u liječenju bolesti izazvane koronavirusom. Cilj ovog projekta je pronaći inhibitore specifične za makrodomene koronavirusa. U prvoj fazi istraživanja planiramo provesti virtualnu pretragu dostupnih biblioteka kemijskih spojeva (s naglaskom na one već odobrene od strane Agencije za hranu i lijekove) kako bismo odabrali potencijalne inhibitore. Zatim ćemo ispitati inhibitorni učinak odabranih spojeva metodama in vitro koristeći sposobnost koronavirusne makrodomene da hidrolizira različite ADP-ribozilirane supstrate. Na kraju će se kandidati koji pokažu najbolje rezultate podvrgnuti ispitivanju in vivo na modelu makrofaga i miša. Očekujemo da će rezultat našeg istraživanja biti spoj, ili nekoliko njih, s potencijalom da postanu lijek za bolest koju izazivaju koronavirusi. Ovim projektom uspostavit ćemo istraživačku platformu za otkrivanje i ispitivanje inhibitora koronavirusnih makrodomena koja će se sastojati od niza računalnih i eksperimentalnih metoda. Ova će se platforma zajedno s našim iskustvom moći aktivirati bilo kada u budućnosti ukoliko se ukaže potreba za pronalaskom novih ili poboljšanjem postojećih inhibitora koronavirusnih makrodomena. ]]></summary_hr><summary_en><![CDATA[In recent history, coronaviruses have proven to be a very serious threat to the human population. Severe acute respiratory syndrome (SARS) coronavirus and the Middle East respiratory syndrome (MERS) coronavirus emerged in 2003 and 2012, respectively. We are currently witnessing a new outbreak caused by the highly pathogenic SARS-coronavirus-2 (SARS-CoV-2) that spread from China all over the world causing serious respiratory disease in humans (COVID-19) with a high mortality rate. All three coronaviruses probably originated in bats and were transmitted to humans. Currently, there are no vaccines or drugs that can treat any zoonotic coronavirus and they are a permanent threat to public health.In the framework of this project, we will try to disable the mechanism that coronaviruses have evolved to manipulate the host antiviral response to their advantage. Our focus will be on a posttranslational modification, i.e., ADP-ribosylation, that plays an important role in antiviral response and innate immunity. Antiviral PARP activity (transfer of ADP-ribose onto different target proteins) leads to the induction of interferon response (a central part of the innate immune system) and inhibition of virus replication. A key role in the regulation of ADP-ribosylation play evolutionarily conserved protein domains called macrodomains which can remove ADP-ribose from modified proteins. All coronaviruses contain such a macrodomain as a part of their non-structural protein 3 (Nsp3) and use them to neutralize effects of antiviral ADP-ribosylation. Coronavirus macrodomains have been shown to be essential for viral pathogenesis; they promote virus replication and suppress interferon response, and as such are promising antiviral drug targets. Inhibition of coronaviruses' macrodomains using small molecules has become a novel therapeutic approach for treating coronavirus-induced disease.The aim of our project is to find coronavirus-specific macrodomain inhibitors with the potential to interfere with SARS-CoV-2 macrodomain activities. First, we will perform virtual screening of FDA-approved and commercial small compound libraries to select potential SARS-CoV-2 macrodomain inhibitors. Next, the inhibitory effect of selected compounds will be validated by testing the ability of the coronavirus macrodomain to hydrolyse different ADP-ribosylated substrates in inhibitor presence in vitro. Finally, the most promising inhibitor candidates will be subjected to in vivo testing using macrophage and mouse models. We hope that our research will result in a compound (or compounds) with the potential of becoming a drug for treating coronavirus-induced disease. Also, our results will contribute to the understanding of the mechanism which coronaviruses use through their macrodomains to promote virus replication and weaken the host immune system. Using the proposed computational and experimental analysis, we will obtain information necessary for designing novel, structure-based, and highly specific coronavirus macrodomain inhibitors. With this project, we will build and establish a streamlined pipeline for coronavirus macrodomain inhibitor discovery which together with our expertise could be mobilised anytime in the future to find/improve macrodomain inhibitors for potential new highly pathogenic coronaviruses.]]></summary_en></project><project>
<id>100024</id><title_hr><![CDATA[Otpornost hrvatskog društva uslijed COVID-19 pandemije - SOCRES]]></title_hr><title_en><![CDATA[]]></title_en><user_id>0</user_id><user_firstLast_name>Branko Ančić</user_firstLast_name><svouser_id>0</svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP-CORONA</proposal_type><proposal_call>2020-04</proposal_call><code>IP-CORONA-2020-04-2044</code><acronim><![CDATA[SOCRES]]></acronim><duration>15.07.2020 - 14.01.2022</duration><status>Završio</status><financ_value>99.362,93 eur</financ_value><scie_area_hr></scie_area_hr><scie_area_en></scie_area_en><scie_field_hr>, </scie_field_hr><scie_field_en>, </scie_field_en><institution_hr><![CDATA[Institut za društvena istraživanja u Zagrebu]]></institution_hr><institution_en><![CDATA[]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[Marija Brajdić Vuković, Lana Peternel, Adrijana Šuljok, Karin Doolan, Mladen Domazet, Danijela Dolenec, Valerija Barada, Dražen Cepić, Željka Tonković, Krešimir Krolo, Drago Župarić-Iljić, Jasminka Lažnjak, Dragan Bagić, Petra Rodik, Paško Bilić, Jaka Primorac, Jelena Puđak, Srđan Golubović, Marija Švajda, Marko Brkić, Jan Šnajder, Ivo Furman, Savas Yildirim, Giacomo D'Alisa]]></team_members_names><keywords_hr><![CDATA[Social resilience, COVID-19 pandemic, coping, adaptive and transformative capacities.]]></keywords_hr><keywords_en><![CDATA[Social resilience, COVID-19 pandemic, coping, adaptive and transformative capacities.]]></keywords_en><summary_hr><![CDATA[Iako istraživanje katastrofa ima dugu povijest u društvenim znanostima, ona su uglavnom usredotočena na lokalizirane prirodne katastrofe poput poplava, potresa i uragana ili na lokalizirane terorističke napade kao što je to bio slučaj s terorističkim napadima u Americi 11. rujna 2001. U tom smislu, radi globalnog obuhvata, COVID-19 pandemija spada u novije izazove u području, kako u pogledu primjerenih konceptualnih alata tako i metoda istraživanja. Dodatno, postojeći uvidi iz istraživanja fokusiranih na širenja virusa, primjerice onog povezanog sa širenjem SARS virusa 2003. godine, pokazuju da iako su epidemiološke mjere i strategije u tom slučaju bile u velikoj mjeri učinkovite u kontroliranju širenja virusa, epidemija ima negativne političke, etičke i socioekonomske učinke (Tognotti, 2013). Drugim riječima, u slučaju virusnih epidemija radi se o katastrofama koje imaju višestruke negativne posljedice. Projekt SOCRES vođen je pitanjem što jača kapacitete pojedinaca, skupina, zajednica i organizacija, ili društva općenito, da mogu pozitivno odgovoriti na prijetnje i negativne učinke katastrofa poput COVID-19 pandemije. Teorijski temelji projekta su rasprave o pojmu društvena otpornost koji se odnosi na kapacitete ljudskih zajednica da izdrže izvanjski uzrokovane šokove koji potresaju njihovu društvenu infrastrukturu te da se od njih uspješno oporave (Adger, 2000). Projekt istražuje tri široko postavljene determinante društvene otpornosti: (1) društvene odnose i mreže, (2) znanje, narative i medijske okviri, i (3) društveni metabolizam i institucijski kapaciteti. Budući da je društvena otpornost multidimenzionalni pojam, njegova razrada zahtijeva interdisciplinarni pristup kao i prikupljanje različitih vrsta empirijskih podataka i analiza. Iako je projekt u svojim temeljima sociološki, oslanjat će se i na teorijske i empirijske uvide iz političke ekonomije i političke ekologije. Koristit će se i različite metode za prikupljanje primarnih podataka kao što su intervjui, opažanja i upitnici te provoditi analiza sekundarnih podataka. Sudionici projektnih istraživanja bit će predstavnici šire javnosti, ali i stručnjaci, političari i aktivisti. Krovni ishod ovog projekta jest bolje razumijevanje sposobnosti prilagodbe, ali i pozitivne transformacije hrvatskog društva uslijed posljedica katastrofa kao što je COVID-19 pandemija. No, rezultirat će i boljim razumijevanjem društveno-kulturnih i institucionalnih preduvjeta za prilagodbu razvojnim ograničenjima koja su specifična za 21. stoljeće. Projekt će biti od interesa donositeljima politika, kao i organizacijama civilnog društva, posebice u pogledu specifičnih mjera koje se mogu poduzeti vezano uz jačanje društvenog kapitala, kriznu komunikaciju ili pak adresiranje širih okolišnih i ekonomskih izazova, a koje doprinose jačanju otpornosti hrvatskog društva. ]]></summary_hr><summary_en><![CDATA[Disaster research has a long-standing history in the social sciences. However, much of this research has focussed on natural, often localized disasters such as floods, earthquakes and hurricanes or localized terrorist attacks including 9/11. The global scope of the COVID-19 pandemic and its detrimental multi-faceted effects present a new challenge to disaster research, including its conceptual tools and approaches to fieldwork. Insights from research on the epidemiological measures and strategies of disease containment for the 2003 epidemic of severe acute-respiratory syndrome (SARS), suggest that although these were fairly effective in controlling the spread of the disease they also had negative political, ethical and socioeconomic effects (Tognotti, 2013). Against this background, the COVID-19 pandemic and its strategies of containment raise the question of what enhances the capacities of individuals, groups and organizations, or society in general, to deal with threats and negative effects more competently? The main research goal of this project is to explore the features of social resilience in Croatian society in the midst of the COVID-19 pandemic and its immediate aftermath. Social resilience is understood as concept which encapsulates individuals, organizations and communities (or society per se) and their abilities and capacities to absorb, cope with and adjust to threats which can be social and/or environmental in nature. Social resilience is the ability of a society to withstand external shocks to its social infrastructure. In this project we will have three research streams (RS) which will explore three determinants of social resilience: (RS1) social relationships and network structures; (RS2) knowledge, narratives and media frames; (RS3) social metabolism and institutional capacities. Since social resilience is a multidimensional concept it requires an interdisciplinary approach and analyses of various scales and empirical sources. In this project we will be drawing on sociological concepts, but also bringing them together with insights from political economy and ecological economics. We will also be drawing on existing data and research instruments whilst building on them and enriching them. Different methods will be combined: interviews, observations, questionnaires and analysis of secondary data. Our respondents will be the general public, but also experts, politicians and activists. An overarching outcome of our analyses will be to have a better understanding of the coping, adaptive and transformative capacities of Croatian society during a crisis situation such as the COVID-19 pandemic. Empirical insights into different facets of social resilience in Croatia would be coherently represented in visual (i.e. Sustainability Doughnut visualisation of overall social resilience), analytical and narrative frames. This project will result in a better understanding of the social governance of epidemiological resilience and the socio-cultural and institutional adaptation to 21st century-specific development constraints. Therefore, the project will be of interest to policy-makers and civil society organizations in terms of its specific recommendations on measures which can be taken, particularly in relation to strengthening social capital, crisis communication and broader environmental and economic concerns, with the purpose of strengthening Croatia’s social resilience.]]></summary_en></project><project>
<id>100025</id><title_hr><![CDATA[Život u doba bolesti COVID-19 – socijalne implikacije za sigurnost i dobrobit ranjivih skupina u europskom kontekstu]]></title_hr><title_en><![CDATA[]]></title_en><user_id>0</user_id><user_firstLast_name>Dalida Rittossa</user_firstLast_name><svouser_id>0</svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP-CORONA</proposal_type><proposal_call>2020-04</proposal_call><code>IP-CORONA-2020-04-2086</code><acronim><![CDATA[VULNERABILITY]]></acronim><duration>10.07.2020 - 09.01.2022</duration><status>Završio</status><financ_value>55.450,98 eur</financ_value><scie_area_hr></scie_area_hr><scie_area_en></scie_area_en><scie_field_hr>, </scie_field_hr><scie_field_en>, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Pravni fakultet]]></institution_hr><institution_en><![CDATA[]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[Marissabell Škorić, Sanja Barić, Dejana Golenko, Irma Kovčo Vukadin, Goran Arbanas, Francesco Trapella,Mojca M. Plesničar  Maria Forsman]]></team_members_names><keywords_hr><![CDATA[COVID-19 social implications; vulnerable groups; state policies; Europe]]></keywords_hr><keywords_en><![CDATA[COVID-19 social implications; vulnerable groups; state policies; Europe]]></keywords_en><summary_hr><![CDATA[U zadnje vrijeme, svijet je iskusio razarajuće posljedice COVID-19 krize u svakom segmentu društvenog života. Izjava UN-ovog glavnog tajnika Antónia Guterresa kako je pandemija prouzročila neviđenu ljudsku patnju i ekonomsku devastaciju širom svijeta pokazala se, nažalost, točnim pokazateljem razmjera i težine njezinih posljedica. I dok se bitka s pandemijom primarno vodila na polju medicinske znanosti, postalo je očito da ograničenja socijalnih prava i usluga i mjere zabrane kretanja mogu dovesti do teških, neželjenih posljedica po ranjive članove društva. Suočene s nemogućnošću napuštanja doma i otežanim prijavljivanjem počinitelja, žrtve obiteljskog nasilja izložene su pojačanom riziku viktimizacije. Kriminološki scenarij porasta kaznenih djela na štetu najmlađih sasvim je moguć uslijed neočekivanih okolnosti i restriktivnih mjera. Ograničenja unutar sustava mentalnog zdravlja tijekom COVID-19 krize mogu predstavljati zapreku u pružanju pomoći žrtvama kaznenih djela i zdravstvenih usluga osobama s duševnim smetnjama. Ranjivost ranjivih nikada nije bila veća i ostaje otvorenim pitanje može li se država nositi sa socijalnim teretom i može li ih adekvatno zaštititi. Znanstvena zajednica ima moralnu, etičku i profesionalnu dužnost odgovoriti na novonastalu krizu i projekt „Život u doba bolesti COVID-19 – socijalne implikacije za sigurnost i dobrobit ranjivih skupina u europskom kontekstu“ je izravan odgovor na tu obvezu.Cilj ovog projekta je kritički istražiti normativne tehnike koje su države implementirale kako bi odgovorile na COVID-19 pandemiju i ocijeniti njihov utjecaj na ravnotežu vlasti, demokratska načela općenito i prava osoba izloženih obiteljskom nasilju, osoba s duševnim smetnjama i djece žrtava kaznenih djela. Istraživački tim analizirat će predmete policijskih postaja u Puli, Rijeci, Zagrebu, Splitu i Osijeku kako bi se istražile fenomenološke i etiološke promjene u kaznenim djelima na štetu djece i zabranjenim ponašanjima vezanim uz nasilje u obitelji. Regionalna raspodjela zadržat će se i u drugoj fazi istraživanja u kojoj će se ispitati iskustva djelatnika udruga (metoda fokus grupa) i izloženost obiteljskom nasilju njihovih korisnika (kvantitativno istraživanje). Isti metodološki okvir primijenit će se tijekom istraživanja informacijskih vještina i kompetencija djelatnika i udruga za vrijeme pandemije. Empirijska faza istraživanja okončat će se studijom na Klinici za psihijatriju Vrapče. Dobiveni teorijski i empirijski rezultati usporedit će se s rezultatima do kojih su došli članovi tima iz Slovenije, Italije i Švedske. S projektnim rezultatima upoznat će se znanstvena, stručna i opća javnost, tvorci politika i same ranjive osobe. Kombiniranjem različitih projektnih taktika u interdisciplinarnom komparativnom okruženju nastojat će se postići krajnji cilj projekta - poboljšanje položaja ranjivih osoba tijekom izvanrednog ili kvaziizvanrednog stanja u europskom kontekstu.]]></summary_hr><summary_en><![CDATA[In recent weeks, humanity has experienced devastating effects of COVID-19 crisis in every segment of social life. The UN Secretary-General António Guterres' statement that COVID-19 pandemic is causing untold human suffering and economic devastation worldwide is, unfortunately, a correct predictor of extent and severity of its effects. While state officials are predominately focused on fighting the pandemic in the medical battlefield, there has been a strong indication that the state reduction of previously attained level of social security rights and services combined with mandatory lockdown measures have severe, unwanted consequences for the most vulnerable members of society. Due to coronavirus mandatory cohabitation, victims of family violence are exposed to higher risk of abuse and deprived from physical space to report the abuser. The risk of child victimisation in respect of mistreatment, abuse, neglect and exploitation is higher than ever, and there is a great probability that criminal offences against the youngest members of society will increase amidst extraordinary circumstances and restrictive measures. Numerous studies have already confirmed that prolonged exposure to criminal acts is a serious risk factor for victims’ mental health and well-being, however, the state restrictions within the psychiatric mental health system can be an obstacle to meet victims’ needs and to adequately provide mental health services for people with mental difficulties. These who were vulnerable are now more vulnerable than ever and question remains whether the state may bear the COVID-19 social burden and adequately protect them. It is of utter importance to emphasize that scientific community has a moral, ethical and professional obligation to respond to the crisis. The project proposal entitled “Life in the time of COVID-19 - social implications on the security and well-being of vulnerable groups in the European context” is a direct response to this obligation.Bearing this in mind, the project is planned to critically evaluate different normative techniques that states have used in order to cope with the COVID-19 pandemia and to assess their direct impact on power balance, democratic principal in general and rights of these who are subjected to family violence, struggling with mental issues or are underage and harmed by criminal offences. The project team members will conduct the empirical research at the five police departments centred in Pula, Rijeka, Zagreb, Split and Osijek in order to find out phenomenological and etiological shifts in crime against children and prohibited behaviours related to family violence. The regional distribution will be maintained in the second phase of empirical research dedicated to exploring the experiences of NGO service providers (focus group study) and exposure to family violence of service users (quantitative research with clients of NGO support system). The identical methodological framework will be applied in the assessment of information literacy skills and competences of NGO stuff and their users in the time of pandemics. The empirical phase of the research will be concluded with a study at the University Psychiatric Hospital Vrapče. The obtained theoretical and empirical project outcomes will be compared with the key research findings reached by Slovenian, Italian and Swedish project researchers. The project results will be shared with scientific and professional community, general public, policy makers and persons associated with vulnerability at research workshops, conferences and science popularisation events and initiatives. By combining different project tactics in interdisciplinary comparative settings, the project research team is strongly determined to reach the final project goal - to enhance the]]></summary_en></project><project>
<id>100026</id><title_hr><![CDATA[Obnavljanje društva: Longitudinalno istraživanje društvenog oporavka u Hrvatskoj nakon pandemije  koronavirusa]]></title_hr><title_en><![CDATA[]]></title_en><user_id>0</user_id><user_firstLast_name>Dinka Čorkalo Biruški</user_firstLast_name><svouser_id>0</svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP-CORONA</proposal_type><proposal_call>2020-04</proposal_call><code>IP-CORONA-2020-04-2032</code><acronim><![CDATA[ReSPoC]]></acronim><duration>15.07.2020 - 14.01.2022</duration><status>Završio</status><financ_value>72.048,58 eur</financ_value><scie_area_hr></scie_area_hr><scie_area_en></scie_area_en><scie_field_hr>, </scie_field_hr><scie_field_en>, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[Margareta Jelić, Mirjana Tonković, Kosta Bovan, Nikola Baketa, Ivan Tomić, Marko Kovačić, Francesca Dumančić, Iva Kapović, Ena Uzelac, Stephen David Reicher,  Dario Spini]]></team_members_names><keywords_hr><![CDATA[Social recovery after pandemic, long-term recovery after coronavirus pandemic, social capital, general population ]]></keywords_hr><keywords_en><![CDATA[Social recovery after pandemic, long-term recovery after coronavirus pandemic, social capital, general population ]]></keywords_en><summary_hr><![CDATA[Pandemija koronavirusa i bolesti COVID-19 izložila je globalni svijet do jučer nezamislivim posljedicama za dobrobit pojedinaca, zajednica i čitavih društava. U borbi protiv virusa zemlje su pribjegle vrlo različitim strategijama. No opći je dojam i stručnjaka i javnosti da je svijet u borbu krenuo prekasno, da će posljedice biti nesagledive za svjetsko stanovništvo i globalno tržište, a posljedice na mentalno zdravlje ljudi i promjene društvenih obrazaca posve su neizvjesne i uglavnom nepoznate. Dosadašnja iskustva čovječanstva s pandemijama ovih razmjera upućuju na to da psihološke i ponašajne reakcije ljudi mogu biti ključne ne samo za prijenos bolesti, nego i za upravljanje krizom uvjetovanim stresom i povezanim društvenim poremetnjama. Stoga su nužno potrebna opsežna i metodološki rigorozna istraživanja, koja će omogućiti analizu psiholoških i društvenih promjena i pridonijeti razumijevanju procesa suočavanja s izvanrednim okolnostima pandemije koronavirusa, te razumijevanju utjecaja tih promjena na percepciju sadašnjega društva i  očekivanja od društva u budućnosti. Stoga je cilj ovoga istraživanja odgovoriti na pitanje kako će (hrvatsko) društvo izgledati nakon pandemije, odnosno kakvu budućnost hrvatskog društva predviđaju građani Hrvatske. Specifično, zanima nas ispitati kako individualna obilježja pojedinaca, te iskustva pojedinaca i zajednice tijekom borbe protiv epidemije određuju percepciju društva u sadašnjosti, te u budućnosti, nakon završetka epidemije. Pritom očekujemo da će osobe koje su tijekom pandemije doživjele više deprivirajućih iskustava i teže se suočavale s novonastalom situacijom imati i pesimističniju sliku svijeta, odnosno u manjem stupnju očekivati nastavak razvoja demokratskog društva kakvog poznajemo, a više zagovarati društvene obrasce sigurnosti, uz veću spremnost na kontrolu države i uskratu individualnih prava i sloboda.  Istraživanje će biti longitudinalno, na uzorku od 1200 odraslih građana Republike Hrvatske u dobi od 18 do 75 godina. Pri tome temeljni doprinos istraživanja vidimo u identificiranju obilježja pojedinaca koji su se (ne)uspješno nosili s pandemijom, kao i u identificiranju razmjera percipiranih i očekivanih društvenih promjena, koje ćemo utjecaje pratiti u tri vala, tijekom razdoblja od godinu dana. Očekujemo da ćemo na temelju analize razmjera očekivanih društvenih promjena i longitudinalnog praćenja stabilnosti tih očekivanja moći donijeti preporuke za upravljanje društvenom promjenom koja će se izvjesno dogoditi.     ]]></summary_hr><summary_en><![CDATA[The COVID-19 pandemic has exposed the global world to threats to individual wellbeing and the welfare of communities and society in a way that was hardly foreseeable and imaginable not very long ago. In fighting the virus different countries have employed very different strategies. However, there is a general impression in both experts and the general public that the world started to fight back too late, that the consequences are going to be long lasting and immense for the world’s population and global market, while the consequences for mental health of people and changes of social patterns in our societies are uncertain and completely unknown so far. By witnessing quite a few pandemics over the history of humankind it has become clear that peoples’ psychological responses and behaviours related to infection may be crucial in both transmission of disease and in managing the accompanying stress of individuals and breakdown of societies (Taylor, 2019). For the latter, there is a need for large-scale and methodologically sound research to enable us to analyse empirical data and advance our understanding of how people cope with extraordinary events like a coronavirus pandemic and how their responses to such a threat shape their worldview, perceptions of the society they live in and their expectations about society in the future.Therefore, the aim of this research proposal is to investigate how (Croatian) society is going to look after the COVID-19 pandemic, i.e., how Croatian citizens perceive their current society and what kind of future changes they predict. Specifically, we want to explore how individual characteristics and experiences of individuals and communities during the coronavirus crisis determine perception of society in the future, after the pandemic finally ends. Our research objectives are fourfold: 1) to explore how individual characteristics, both sociodemographic and selected individual variables predict our respondents’ perceptions of current and future makeup of their society; 2) to identify how individual characteristics interact with experiences of surviving the COVID-19 pandemic in predicting respondents’ perceptions of the current and future social makeup; 3) to determine (in)stability of changes of how the respondents perceive both current and future social makeup over the course of about one year; 4a) to compare changes in the perception of current and future social makeup among different age groups; i.e., among adolescents, adults and seniors; 4b) to establish if trends of the perceived current and future changes in the social makeup follow the objective vulnerability/risks of COVID-19 in different age groups; i.e., we want to explore if those who were the least likely to get seriously ill (youths) also perceive and expect a more favourable makeup of future society compared to those who were at higher risk (senior citizens). The study is designed as an on-line longitudinal research with a sample of 1200 adult participants from the general public of Croatia, aged 18 to 75. We expect that pre-crisis individual characteristics, i.e., those characteristics people enter the crisis with (e.g., sociodemographic and individual traits) as well as characteristics of their experiences during the crisis contribute significantly to what people expect and how they perceive their society in the future. Specifically, individuals who have struggled with more negative experiences and coped with them less efficiently will perceive the future society in a more pessimistic way; they will expect in lesser degree the democratic makeup of the society to continue in a way we know it, while expecting more and being more ready for supporting policies aimed to build and preserve security as the major social goal. We also expect them to be more ready for a broader state control over its citizens and to tolerate more restrictions related to individual rights and liberties. Hence, the present research contributes to the literature on social capital by exploring its pillar component – social trust, networking/cooperation and social norms - in a relatively new democracy being challenged by the global health crisis. Social capital in general may not serve as a panacea for social recovery after a major crisis; however, it is a crucial building-block showing the capacity of the communities and society to “bounce back” and recover. Hence, the present research looks at how Croatian citizens perceive the current level of social capital and the future prospect of it after experiencing a global pandemic. Furthermore, the contribution of the study is in identifying characteristics of those individuals who have dealt with crisis (un)successfully, as well as in identifying a range of expected social changes to be followed in three waves. Based on analyses and follow-up of people’s perceptions and expectations of social changes in the future we shall be able to offer recommendations for managing social change that is inevitably going to happen.]]></summary_en></project><project>
<id>100027</id><title_hr><![CDATA[Višeslojni okvir za karakterizaciju širenja informacija putem društvenih medija tijekom krize COVID-19 (akronim: InfoCoV)]]></title_hr><title_en><![CDATA[]]></title_en><user_id>0</user_id><user_firstLast_name>Ana Meštrović</user_firstLast_name><svouser_id>0</svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP-CORONA</proposal_type><proposal_call>2020-04</proposal_call><code>IP-CORONA-2020-04-2061</code><acronim><![CDATA[InfoCoV]]></acronim><duration>15.07.2020 - 14.01.2022</duration><status>Završio</status><financ_value>73.916,33 eur</financ_value><scie_area_hr></scie_area_hr><scie_area_en></scie_area_en><scie_field_hr>, </scie_field_hr><scie_field_en>, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Odjel za informatiku]]></institution_hr><institution_en><![CDATA[]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[Sanda Martinčić-Ipišić, Slobodan Beliga, Karlo Babić, Milan Petrović, Mihaela Matešić, Zoran Levnajić, Marko Pranjić]]></team_members_names><keywords_hr><![CDATA[Information Spreading, Social Media, Multilayer Networks, Social Networks Analysis, Natural Language Processing, Deep Learning ]]></keywords_hr><keywords_en><![CDATA[Information Spreading, Social Media, Multilayer Networks, Social Networks Analysis, Natural Language Processing, Deep Learning ]]></keywords_en><summary_hr><![CDATA[Istraživanje obrazaca širenja informacija putem društvenih medija od velike je važnosti u kriznim situacijama kao što je pandemija uzrokovana virusom COVID-19. Razumijevanje obrazaca komuniciranja može pomoći u ublažavanju nesigurnosti i straha te osnaživanju odgovornoga individualnog i grupnog ponašanja, a također i u sprječavanju širenja dezinformacija, koje mogu biti štetne. Za razumijevanje širenja informacija važna je kvantitativna i kvalitativna analiza tekstualnih poruka koje se objavljuju na društvenim mrežama. Glavni je cilj projekta InfoCoV proučavanje i karakterizacija obrazaca širenja informacija tematski vezanih uz COVID-19 primjenom najnovijih istraživačkih pristupa iz područja umjetne inteligencije. U okviru recentnih istraživanja u domeni računalne analize prirodnoga jezika razvijeni su relativno uspješni pristupi za detekciju dezinformacija (engl. fake news) te za klasifikaciju različitih tipova informacija, kao što su npr. informacije iznesene s pozitivnim i negativnim stavovima. Međutim, kriza COVID-19 donosi nove izazove zbog velike zastupljenosti komunikacije u društvenim medijima, koja je rezultirala velikim skupovima tekstualnih podataka, novim specifičnim temama koje su došle u fokus te novom terminologijom.  U okviru istraživanja predložit će se višeslojni okvir (engl. multilayer framework) za karakterizaciju širenja informacija na temelju tri skupine značajki: (i) tekstualni sadržaj poruke, (ii) kontekst širenja poruke na društvenim mrežama te (iii) dinamika širenja poruke. Kako bi se istražili različiti aspekti širenja informacija, predloženi pristup integirat će metode za analizu tekstova iz područja računalne analize prirodnoga jezika i metode iz područja analize društvenih mreža. Definirat će se višeslojna kompleksna mreža koja obuhvaća reprezentaciju različitih razina širenja informacija u društvenoj mreži (objavljivanje poruka, komentiranje poruka, dijeljenje poruka i sl.). Za potrebe klasifikacije informacija istražit će se i primijeniti najnoviji postupci iz područja strojnog učenja koji uključuju duboko učenje.Rezultati ovoga interdisciplinarnog projekta, u koji su uključeni istraživači iz različitih područja znanosti (informacijske znanosti, računalstvo, fizika i lingvistika) omogućit će bolje razumijevanje obrazaca širenja informacija i komunikacije vezane uz COVID-19. Vrlo važan ishod ovoga istraživanja bit će skupovi podataka koji sadrže tekstove s najčitanijih internetskih portala i tekstualne objave na društvenim mrežama (Twitter, Facebook), tematski povezane s krizom COVID-19. Glavni fokus istraživanja bit će tekstovi na hrvatskom jeziku, međutim, kako bi rezultati istraživanja bili usporedivi s drugim sličnim studijama, analizirat će se i komunikacija na engleskom jeziku. Svi rezultati projekta bit će javno dostupni na mrežnim stranicama projekta i predstavljat će vrijednu imovinu za buduća istraživanja koja se bave sličnom tematikom.]]></summary_hr><summary_en><![CDATA[Communication through social media has been gaining importance in responses to major crises, such as COVID-19. In emergency situations, there is an urgent need to rely on trustworthy information. On the other side, we are all witnessing a huge amount of misinformation (fake news, conspiracy theories also spreading on social media, especially during a crisis. In this light, understanding and recognising the information spreading patterns in social media plays an important role and opens various possibilities for alleviating fear, stereotyping and uncertainty, strengthening responsible individual and group behaviour and trust in public authorities in social media communications. The automatic recognition of information spreading patterns may improve various aspects of crisis communication, such as: the classification of positive and negative public attitudes to certain policies and restrictions; choosing the best communication patterns to promote important information in social media; detection, prediction and preventing fake news spreading; and many more. Hence, it is important to recognise how different types of information are transmitted and dispersed through social media during crisis communication.The first step toward understanding the information spreading patterns is to perform a quantitative and qualitative analysis of textual information in social media and to identify which characteristics of information spreading can differentiate between various information spreading patterns. The main objective of the proposed research is to study and characterise information spreading patterns in the social media during the COVID-19 pandemic.In previous research, it has already been shown that there are differences in spreading patterns of various kinds of information, as for example, information with a positive or negative attitude (L, Wang et al., 2019; R.; Q Wang et al., 2017; R. Alvarez et al., 2015; W. Ferrara & Z. Yang, 2015; A. Das, et al., 2014); or misinformation vs. mainstream information (A. Bessi et al., 2015; M. Del Vicario et al., 2016; N. Ruchansky, S. Seo & Y. Liu, 2017; S. Vosoughi et al., 2018; J. Reis et al., 2019; F. Pierri et el., 2020). However, the COVID-19 crisis brings a whole new realm of challenges in terms of large communication volumes that results with massive datasets, new terminology, new aspects and new specific topics that have come into the focus (the pandemic spreading data, mortality rate, healthcare issues, government policies, restrictions and other socio-economic issues related to the pandemic, etc.). A large number of existing studies that analyse information spreading are focused on information characterisation only by its spreading dynamics (Del Vicario et al., 2016; M. Jalili, & M. Perc, 2017) or only by its content (K. Bontcheva et al., 2014), however, new trends in the research propose a combination of various aspects of information spreading (F. Monti et al., 2019; K. Shu et al., 2017) and the proposed research is going in that direction.In this research we will propose a novel multilayer framework that defines a set of approaches, methods and network-based models that capture three aspects of information spreading analysis: (i) content, (ii) context and (iii) dynamic. The content-based analysis of textual information will rely on the various natural language processing methods and approaches for the tasks such as keywords/keyphrases extraction, text classification. Additionally, this segment of analysis will include descriptive statistics of the textual information related to COVID-19 crisis communication characteristics. The context-based analysis refers to the analysis of various multilayer network properties on the global, middle and local scale. The analysis of the dynamics involves the analysis of cascade dynamics and some other properties such as information trends changing over time.Within the proposed framework, we will study empirical data related to COVID-19 crisis communication crawled from various social media sources, such as Twitter or Facebook and online portals such as index.hr, jutarnji.hr, etc. The main focus of our datasets will be texts in the Croatian language, however, to be comparable with other studies, we will perform experiments with texts in the English language as well.We expect that the results of this project will enable a better understanding of the information spreading patterns and communication in social media during the COVID-19 pandemic. These results will include multilayer framework, corpus statistics, set of information spreading characteristics, and an information spreading classifier. One very important outcome of this research will be the datasets of news articles, messages and networks communication related to the COVID-19 crisis. All project results will be free and publicly available on the project’s website and will represent valuable assets for many possible future research in various domains such as data science, sociology, psychology, communicology, linguistic, etc.]]></summary_en></project></projects>